bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation of Epirubicin Aptasensor Using Curcumin as Hybridization Indicator: Competitive Binding Assay between Complementary Strand of Aptamer and Epirubicin
Authors: Hashkavayi Ayemeh Bagheri , Raoof Jahan Bakhsh , Ojani Reza 
Published: December 2017

AbstractThe present work explains the fabrication of a novel electrochemical aptasensor for identifying and measuring the epirubicin (Epi) by using curcumin (Cur) as an anticancer electrochemical indicator. The aptasensor prepared by immobilizing the thiolated aptamer on the surface of graphite screen‐printed electrode modified with gold nanoparticles/functionalized multiwall carbon nanotubes, ionic liquid and chitosan nanocomposite (AuNPs/FMWCNTs‐IL‐Chit/SPE). To evaluate the willingness of aptamer to interaction with Epi in the presence of complementary strand DNA, competitive binding assay between the complementary strand of aptamer and Epi were used. Cur tends to bound to the grooves of two strands DNA. With increasing the concentration of Epi in the range of 0.007–7.0 μM, the peak current of Cur decreased, due to the formation of aptamer‐Epi complex and decreasing the amount of complementary strand DNA. Through the control experiments, we examined the response of fabricated aptasensor for some anticancer drugs, which have a structure similar to the Epi. The results showed that using the thiol‐terminated aptamer as a recognition layer led to a sensor with a high tendency for Epi compared to other anticancer drugs.
Augmentative Approaches in Family‐Based Treatment for Adolescents with Restrictive Eating Disorders: A Systematic Review
Authors: Richards Imogen Lim , Subar Anni , Touyz Stephen , Rhodes Paul 
Published: December 2017

AbstractObjectiveTo systematically review the literature reporting outcomes of augmentative family‐based treatment (FBT) interventions for adolescents with restrictive eating disorders (EDs).MethodArticles were identified through a systematic search of five electronic databases (PsycINFO, MEDLINE, EMBASE, CINAHL, Cochrane Database).ResultsThirty articles were included, reporting on FBT augmentations featuring adjunctive treatment components, modified treatment structure and/or content with adherence to FBT principles, and adaptations allowing FBT delivery in different settings. All reported significant improvements in weight and/or ED symptoms at end‐of‐treatment, although few compared augmentative and standard FBT interventions and good quality follow‐up data was generally lacking.ConclusionsThere is early evidence for the effectiveness of augmentative FBT‐based approaches in facilitating weight and/or ED symptom improvements for adolescents with restrictive EDs. There remains a lack of robust evidence demonstrating superior effects of such approaches over standard FBT, and further controlled studies are required to expand on the current evidence. Copyright © 2017 John Wiley & Sons, Ltd and Eating Disorders Association.
Energy‐efficient joint power control and resource allocation for cluster‐based NB‐IoT cellular networks
Authors: Zhu Shuqiong , Wu Wenquan , Feng Lei , Zhao Pan , Zhou Fanqin , Yu Peng , Li Wenjing 
Published: December 2017

AbstractAs a new cellular technology introduced in 3rd Generation Partnership Project (3GPP) Release 13, Narrow‐band Internet of Things (NB‐IoT) provides wide‐area coverage for massive IoT devices. In the perspective of NB‐IoT business applications, it is easily known that energy efficiency is of utmost importance. In this paper, we propose an energy‐efficient joint resource allocation and power control for cluster‐based NB‐IoT cellular networks. The scheme mainly consists of 2 parts, ie, the formation of NB‐IoT device clusters and joint optimization of power and channel allocation. Firstly, by considering the geographical distribution density and the communication capability of NB‐IoT devices, we propose a fast cluster formation scheme to categorize a group of devices into multiple clusters. The cluster head is selected based on the strategy of maximal remaining battery energy due to its higher power consumption than that of clustered devices. Then, a joint optimization of resource and power is proposed for the maximization of energy efficiency of cluster‐based NB‐IoT cellular networks. Exploiting the properties of an objective function, we transform the original nonconvex optimization problem into equivalent 2‐step subproblems. In the first step, the optimal power allocation for any feasible channel reuse assignments is solved by finding the Nash equilibrium point based on noncooperative gaming. In the second step, the resource assignment problem is modeled as bipartite graphs matching and a Hungarian algorithm is used to obtain the perfect matching of channel reusing for maximal energy efficiency. Numerical results demonstrate the remarkable improvements in terms of energy efficiency and device access rate during a period by using the proposed scheme.
Human T cell responses to Dengue and Zika virus infection compared to Dengue/Zika coinfection
Authors: Badolato‐Corrêa Jessica , Sánchez‐Arcila Juan Camilo , Alves de Souza Thiara Manuele , Santos Barbosa Luciana , Conrado Guerra Nunes Priscila , da Rocha Queiroz Lima Monique , Gandini Mariana , Bispo de Filippis Ana Maria , Venâncio da Cunha Rivaldo , Leal de Azeredo Elzinandes , de‐Oliveira‐Pinto Luzia Maria 
Published: December 2017

AbstractIntroductionZika virus (ZIKV) and dengue virus (DENV) co‐circulated during latest outbreaks in Brazil, hence, it is important to evaluate the host cross‐reactive immune responses to these viruses. So far, little is known about human T cell responses to ZIKV and no reports detail adaptive immune responses during DENV/ZIKV coinfection.MethodsHere, we studied T cells responses in well‐characterized groups of DENV, ZIKV, or DENV/ZIKV infected patients and DENV‐exposed healthy donors. We evaluated chemokine receptors expression and single/multifunctional frequencies of IFNγ, TNF, and IL2‐producing T cells during these infections. Even without antigenic stimulation, it was possible to detect chemokine receptors and IFNγ, TNF, and IL2‐producing T cells from all individuals by flow cytometry. Additionally, PBMCs’ IFNγ response to DENV NS1 protein and to polyclonal stimuli was evaluated by ELISPOT.ResultsDENV and ZIKV infections and DENV/ZIKV coinfections similarly induced expression of CCR5, CX3CR1, and CXCR3 on CD4 and CD8 T cells. DENV/ZIKV coinfection decreased the ability of CD4+ T cells to produce IFNγ+, TNF+, TNF + IFNγ+, and TNF + IL2+, compared to DENV and ZIKV infections. A higher magnitude of IFNγ response to DENV NS1 was found in donors with a history of dengue infection, however, a hyporesponsiveness was found in acute DENV, ZIKV, or DENV/ZIKV infected patients, even previously infected with DENV.ConclusionTherefore, we emphasize the potential impact of coinfection on the immune response from human hosts, mainly in areas where DENV and ZIKV cocirculate.
IMPLEMENTATION OF AN EVIDENCED‐BASED PARENTING PROGRAM IN A COMMUNITY MENTAL HEALTH SETTING
Authors: Roosa Ordway Monica , McMahon Thomas J. , De Las Heras Kuhn Lourdes , Suchman Nancy E. 
Published: December 2017

ABSTRACTThe process of mental health intervention implementation with vulnerable populations is not well‐described in the literature. The authors worked as a community‐partnered team to adapt and pilot an empirically supported intervention program for mothers of infants and toddlers in an outpatient mental health clinic that primarily serves a low‐income community. We used qualitative ethnographic methods to document the adaption of an evidence‐based intervention, Mothering from the Inside Out, and the pilot implementation in a community mental health clinic. Seventeen mothers and their identified 0‐ to 84‐month‐old children were enrolled in the study. Key lessons from this implementation include (a) the importance of formative work to build community relationships and effectively adapt the intervention to meet the needs of the therapists and their clients, (b) the importance of designing plans for training and reflective supervision that fit within the flow of the clinic and can tolerate disruptions, and (c) that use of an interdisciplinary approach is feasible with the development of a plan for communication and the support of a trained reflective clinical supervisor. These key lessons advance the scientific knowledge available to healthcare managers and researchers who are looking to adapt mental health clinical interventions previously tested in clinical trials to implementation in community settings.
CONFIGURING PROCESS VARIANTS THROUGH SEMANTIC REASONING IN SYSTEMS ENGINEERING
Authors: Detro Silvana Pereira , Portela Edoardo , Rocha Eduardo Loures , Panetto Hervé , Lezoche Mario 
Published: December 2017

ABSTRACTWhen dealing with processes, engineering systems need to be able to deal with the existence of many versions of the same process, known as variants. Each process variant aims to represent a specific business context but, due to some differences in the activities, resources, and control flow, they may differ in their logic. As result, the concept of a customizable process model has emerged. A process model can be customized by representing the process family in one single model deriving a variant through transformations in this single model. However, the process customization is not a trivial‐task. It must be ensured that the variant is correct. Besides, the resulting variant must respect all requirements related to the application context and internal and external regulations, among others. In addition, recommendations and guidance should be provided during the customization. In this context, this research aims to propose a framework for customizing variants according to the user's requirements. The customization is achieved by reasoning in an ontology based on the rules for selecting a variant, in the internal/external regulations, and on expert knowledge.
A FRAMEWORK TO IMPROVE PERFORMANCE MEASUREMENT IN ENGINEERING PROJECTS
Authors: Zheng Li , Baron Claude , Esteban Philippe , Xue Rui , Zhang Qiang 
Published: December 2017

ABSTRACTPerformance measurement enables project managers to monitor the project progress and evaluate results. However, several issues remain, such as an unbalanced use of leading and lagging indicators. Lagging indicators are used to track how things are going. Leading indicators are used as precursors to the direction towards which things are going. The goal of this paper is to develop leading indicators to improve the measurement of projects performance. To address this issue, we consider the measurement processes and indicators in systems engineering measurement that promotes leading indicators. Our objective is to extend the performance measurement activities in the Project Management Body of Knowledge (PMBoK version 5) by adapting the good practices in systems engineering measurement resulting in the proposal of a framework. Thereby, systems engineering leading indicators can be applied to project performance measurement, thus providing project managers with a wider type of indicators and measurement techniques.
Contribution of Water Management and Flood Protection to Food Security and Sustainable Development of Coastal and Deltaic Areas
Authors: Schultz Bart 
Published: December 2017

AbstractIn the field of irrigation, drainage and flood protection are two items crucial for the world's population, as well as for the work of the International Commission on Irrigation and Drainage (ICID) as a global association of professionals in the water sector. The first concerns the contribution of water management to food security and the second the impacts of man‐induced changes in land use and climate change on living and working in coastal and deltaic areas. These two items are presented in light of the rapidly changing and urbanizing world. The first item is mainly based on the work that was done with a great involvement of many specialists for the 6th and 7th World Water Forums and the second one on research by the author during the past decades. Copyright © 2017 John Wiley & Sons, Ltd.
Age‐Related Deterioration of Bone Toughness Is Related to Diminishing Amount of Matrix Glycosaminoglycans (GAGs)
Authors: Wang Xiaodu , Hua Rui , Ahsan Abu , Ni Qingwen , Huang Yehong , Gu Sumin , Jiang Jean X 
Published: December 2017

ABSTRACTHydration status significantly affects the toughness of bone. In addition to the collagen phase, recent evidence shows that glycosaminoglycans (GAGs) of proteoglycans (PGs) in the extracellular matrix also play a pivotal role in regulating the tissue‐level hydration status of bone, thereby affecting the tissue‐level toughness of bone. In this study, we hypothesized that the amount of GAGs in bone matrix decreased with age and such changes would lead to reduction in bound water and subsequently result in a decrease in the tissue‐level toughness of bone. To test the hypothesis, nanoscratch tests were conducted to measure the tissue‐level toughness of human cadaveric bone specimens, which were procured only from male donors in three different age groups: young (aged 26 ± 6 years), mid‐aged (aged 52 ± 5 years), and elderly (aged 73 ± 5 years), with 6 donors in each group. Biochemical and histochemical assays were performed to determine the amount and major subtypes of GAGs and proteoglycans in bone matrix. In addition, low‐field nuclear magnetic resonance (NMR) measurements were implemented to determine bound water content in bone matrix. The results demonstrated that aging resulted in a statistically significant reduction (17%) of GAGs in bone matrix. Concurrently, a significant deterioration (20%) of tissue‐level toughness of bone with age was observed. Most importantly, the deteriorated tissue‐level toughness of bone was associated significantly with the age‐related reduction (40%) of bound water, which was partially induced by the decrease of GAGs in bone matrix. Furthermore, we identified that chondroitin sulfate (CS) was a major subtype of GAGs, and the amount of CS decreased with aging accompanied with a decrease of biglycan that is a major subtype of PGs in bone. The findings of this study suggest that reduction of GAGs in bone matrix is likely one of the molecular origins for age‐related deterioration of bone quality. © 2017 The Authors. JBMR Plus is published by Wiley Periodicals, Inc. on behalf of the American Society for Bone and Mineral Research.
Deletion of BCG Hip1 protease enhances dendritic cell and CD4 T cell responses
Authors: Bizzell Erica , Sia Jonathan Kevin , Quezada Melanie , Enriquez Ana , Georgieva Maria , Rengarajan Jyothi 
Published: December 2017

Abstract
Dendritic cells (DCs) play a key role in the generation of CD4 T cell responses to pathogens. Mycobacterium tuberculosis (Mtb) harbors immune evasion mechanisms that impair DC responses and prevent optimal CD4 T cell immunity. The vaccine strain Mycobacterium bovis Bacille Calmette-Guérin (BCG) shares many of the immune evasion proteins utilized by Mtb, but the role of these proteins in DC and T cell responses elicited by BCG is poorly understood. We previously reported that the Mtb serine protease, Hip1, promotes sub-optimal DC responses during infection. Here, we tested the hypothesis that BCG Hip1 modulates DC functions and prevents optimal antigen-specific CD4 T cell responses that limit the immunogenicity of BCG. We generated a strain of BCG lacking hip1 (BCGΔhip1) and show that it has superior capacity to induce DC maturation and cytokine production compared with the parental BCG. Furthermore, BCGΔhip1-infected DCs were more effective at driving the production of IFN-γ and IL-17 from antigen-specific CD4 T cells in vitro. Mucosal transfer of BCGΔhip1-infected DCs into mouse lungs induced robust CD4 T cell activation in vivo and generated antigen-specific polyfunctional CD4 T cell responses in the lungs. Importantly, BCGΔhip1-infected DCs enhanced control of pulmonary bacterial burden following Mtb aerosol challenge compared with the transfer of BCG-infected DCs. These results reveal that BCG employs Hip1 to impair DC activation, leading to attenuated lung CD4 T cell responses with limited capacity to control Mtb burden after challenge.
Effect of extrusion temperature and screw speed on properties of oat and rice flour extrudates
Authors: Sandrin Raceli , Caon Thiago , Zibetti André Wüst , de Francisco Alicia 
Published: December 2017

AbstractBACKGROUNDWhole oat and rice flours were mixed to develop instant flours by a high pressure and low mechanical shear extrusion process. The screw profile was designed aiming to obtain an infant food with gelatinized starch and high hydration ability. Response surface methodology was selected to study the impact of operating parameters such as temperature and screw speed (73–186 °C; 109–391 rpm) on physicochemical and pasting properties of the final extruded product. The main challenge of this study was to process high oats content, since they are characterized by high lipid and fiber content, which impact on material processing.RESULTSThe optimal response was achieved at 170 °C and 350 rpm. The optimal expansion ratio, bulk density, water absorption index, and water solubility index were 2.24, 289.65 kg m−3, 6.42 g g−1, and 4.75 g g−1 respectively. Overall, both temperature and screw speed affected the responses studied, except for water absorption index (only screw speed affected this response). Although lipids from oats reduce the expansion ratio of extrudates compared with samples containing higher starch proportions, their lipids protect the starch granules from mechanical degradation when higher screw speed values are used. As a result, both ungelatinized and gelatinized starches may be found in extrudates, which was confirmed by pasting property analyses.CONCLUSIONHigh oat content may be efficiently processed by optimizing the extruder conditions (temperature, screw speed, and profile), improving the nutritional properties of the final product. © 2017 Society of Chemical Industry
Use of Tunisian flavored olive oil as anisakicidal agent in industrial anchovy marinating process
Authors: Trabelsi Najla , Marotta Stefania M , Giarratana Filippo , Taamali Amani , Zarrouk Mokhtar , Ziino Graziella , Giuffrida Alessandro 
Published: December 2017

AbstractBACKGROUNDNatural compounds are more frequently used against Anisakis, responsible for the important fish‐borne disease anisakidosis. The aim of the study was to evaluate the effectiveness of enriched Tunisian olive oil with different spices (cumin, turmeric, clove, thyme, and lemon) against Anisakis larvae type 1.RESULTSIn vitro experiment: larvae were submerged separately in the aforementioned oils and then examined to check viability. For each oil, LT50 and LT100 were calculated. Turmeric and cumin oils are the most effective against the parasites; followed by lemon, thyme and clove oils. For the in vivo experiment, turmeric and cumin oils were tested in anchovy fillets previously artificially parasitized with L3 larvae. Cumin was the most effective against parasites (dead after 5 days) compared with turmeric (8 days). For the two oils, the resulting odor was pleasant, as was the taste, while changes in color were much more evident in turmeric fillets.CONCLUSIONAll the flavored oils demonstrated a good nematodical action against Anisakis. Cumin oil was the most effective against encysted larvae. Turmeric oil showed the best activity in the in vitro experiment. The use of flavored oils in the marinating process could represent an efficient strategy to devitalize Anisakis. © 2017 Society of Chemical Industry
Mesenchymal chondrosarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study on 57 patients
Authors: Tsuda Yusuke , Ogura Koichi , Hakozaki Michiyuki , Kikuta Kazutaka , Ae Keisuke , Tsuchiya Hiroyuki , Iwata Shintaro , Ueda Takafumi , Kawano Hirotaka , Kawai Akira 
Published: December 2017

BackgroundThis study aimed to elucidate the clinical features and prognostic factors of mesenchymal chondrosarcoma (MCS) and investigate optimal treatment strategies.MethodsData from 57 patients with MCS were collected from a Japanese Musculoskeletal Oncology Group (JMOG) and retrospectively analyzed.ResultsData from 29 males and 28 females were collected. Primary tumor sites were the head and neck (7 patients), trunk (35 patients), and extremities (15 patients). The tumors originating in the trunk were significantly associated with a worse OS compared with those originating at the other sites in all patients and those with localized disease (P = 0.020 and P = 0.019, respectively). In patients with localized disease, the tumors originating in the head and neck were significantly associated with better OS and MFS compared with those originating in the trunk (P = 0.024 and P = 0.014, respectively). Positive surgical margin was significantly correlated with the worse LRFS (P = 0.018). Adjuvant chemotherapy exhibited a clear trend toward improved OS when MCS was localized in the trunk or extremities (P = 0.057).ConclusionsAdequate surgery is considered to be the mainstay of treatment for localized MCS. Prognosis was different depending on the site of tumor origin.
Micro morphological observation and mechanism analysis of boundary layer evolution in mixed powder lubrication
Authors: Wang Chao , Wang Wei , Liu Yong , Liu Kun 
Published: December 2017

AbstractIn mixed‐powder‐lubricated interfaces, the lubrication performance is strongly affected by evolution of the boundary layer features. Therefore, the current investigation uses a laser microscopy system to observe the behaviours of boundary layer formed on the brass specimens during the process of graphite‐lubricated 0.45 C steel (HRC56) sliding upon brass alloy (HV160). The evolution process of mixed powder lubrication can be divided into 4 typical stages: running‐in, stable, deterioration, and damage. Multiple micro phenomena are observed in the boundary layers at different stages. These include extent of layer coverage, flaking, local adhesion, lamellar shedding, blisters, pits, and abrasion damage. These phenomena indicate that the boundary layer deteriorates from full coverage to a damaged powdery film, and eventually the serious wear on metal substrate. Moreover, an interface model of mixed powder lubrication is established to explain the changes in boundary layers. The model displays that the typically micro events above are related to the quantitative degree of overlapping of the asperities between opposing surfaces. At first, many particles bear the load collectively and adapt to velocity differences through inner shearing in powder layer. Later, plastic deformation and abrasion between asperities play a major role in surface velocity accommodation, and the metal substrates bear the load more directly.
Assessment of an Objective Method of Dyskinesia Measurement in Parkinson's Disease
Authors: Chung Kathryn A. , Lobb Brenna M. , Murchison Charles F. , Mancini Martina , Hogarth Penelope , Nutt John G. 
Published: December 2017

AbstractBackgroundThe goal of this study was to validate an objective method of measuring levodopa induced dyskinesia in Parkinson's disease (PD).MethodsTo characterize agreement between the clinician‐based measure and a force plate, we assessed dyskinesia in PD subjects participating in a randomized and blinded clinical trial of an adenosine A2A anatagonist. Convergent validity and intra‐class correlations were evaluated between the objective force plate measure and clinician assessments.ResultsAll measures correlated across time and detected differences in treatments.ConclusionOur results indicate that objective measure from a force plate is in scale agreement with clinical ratings of dyskinesia severity, indicating it as a reliable method to measure LID objectively but with greater resolution to detect changes in LID.