bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accessibility problems in home environment for seniors in Latvia: Experience from the research project innovAge (WP2)
Authors: Tomsone S. , Saukuma L. , Liepina Z. , Zalkalns J. 
Published: January 2018

Studies on relations between health and environment indicate that accessibility positively influence healthy life expectancy, as accessible home environment and neighbourhood support mobility, daily activities and social participation in old age. One of the tasks in the EC 7th framework research project innovAge (2012-2015) aimed to develop an IT tool to support seniors’ involvement in decisions about their housing options and help them to become active partners in choice and supply of housing.
This study aims to explore seniors’ opinions about accessibility in their physical home environment based on analysis of data - interview records and notes - from two study stages in the research project innovAge (WP2).
Participants, at the first stage - 8 seniors and at the second stage - 10 seniors, represented variety of living conditions, family situations and functional abilities. Participation in the study was voluntary and the participants had right to withdraw from the study at any stage.
Usually, barriers in home environment seniors consider late, when functional abilities decreases substantially. The most common places where environmental barriers appear are sanitary spaces, kitchen and entrance of the home. Despite the environmental barriers and functional limitations, seniors remain in their homes, mainly because in Latvia do not exist traditions to seek options for relocation, as well as there are no policies and services to support this. In few municipalities options exist to adapt home environment, but it refers only to cases of severe disability for persons using wheelchair. Usually, the need for environment adaptations for seniors is replaced by care services, thus meeting also the needs for seniors’ socialization. Regarding possibilities to adapt home environment, strong prejudices exist (bath vs. shower, disadvantages of living on the first floor, etc.). Seniors admitted that they lack knowledge and experience on housing adaptations, but emphasized that the environmental accessibility in a wider context, including the neighbourhood and services, is essential.
The close cooperation with participants facilitated the researchers’ understanding of the seniors’ complex views and needs regarding their home environment and related issues, which are important for developing housing policies for senior citizens in Latvia. Despite the specified accessibility problems in home environment, the seniors evaluated usability of their homes generally high.
Two G-box–like elements essential to high gene expression of SlAKR4B in tomato leaves
Authors: Suekawa Marina , Fujikawa Yukichi , Esaka Muneharu 
Published: January 2018

Abstract
Aldo-keto reductases (AKRs) play important roles in aldehyde detoxification as well as primary and secondary metabolism in plants. We previously reported inducible expression of a Solanum lycopersicum AKR4B (SlAKR4B) in tomato leaves treated with salicylic acid and jasmonic acid, and high promoter activity of SlAKR4B in tomato leaf protoplasts. In this study, we investigated the expression response of SlAKR4B in the tomato leaves with infiltration treatment and the cis-element(s) involved in high promoter activity. Gene expression analysis in tomato leaf protoplasts and buffer-infiltrated tomato leaves suggested that cell damage caused the increased expression of SlAKR4B. Promoter activity of SlAKR4B was significantly reduced by mutation of two G–box like elements. It is suggested that the two G–box like elements are responsible for the high promoter activity.
A Note on Mitsumatsu’s Construction of a Leafwise Symplectic Foliation
Authors: Mori Atsuhide 
Published: January 2018

Abstract
Mitsumatsu [9] constructed a leafwise symplectic structure of the Lawson foliation of S5. Following his construction, we improve a previous result of the author [11] on convergence of contact structure to codimension one foliation, and give a sufficient condition for convergence to foliation with leafwise symplectic structure. As an application, we show that the product S4 × S1 admits infinitely many codimension one leafwise symplectic foliations.
The Logical Complexity of Finitely Generated Commutative Rings
Authors: Aschenbrenner Matthias , Khélif Anatole , Naziazeno Eudes , Scanlon Thomas 
Published: January 2018

AbstractWe characterize those finitely generated commutative rings which are (parametrically) bi-interpretable with arithmetic: a finitely generated commutative ring A is bi-interpretable with $(\mathbb{N},{+},{\times })$ if and only if the space of non-maximal prime ideals of A is nonempty and connected in the Zariski topology and the nilradical of A has a nontrivial annihilator in $\mathbb{Z}$. Notably, by constructing a nontrivial derivation on a nonstandard model of arithmetic we show that the ring of dual numbers over $\mathbb{Z}$ is not bi-interpretable with $\mathbb{N}$.
Three-dimensional structure of clumpy outflow from supercritical accretion flow onto black holes
Authors: Kobayashi Hiroshi , Ohsuga Ken , Takahashi Hiroyuki R , Kawashima Tomohisa , Asahina Yuta , Takeuchi Shun , Mineshige Shin 
Published: January 2018

Abstract
We perform global three-dimensional (3D) radiation-hydrodynamic (RHD) simulations of outflow from supercritical accretion flow around a 10 M⊙ black hole. We only solve the outflow part, starting from the axisymmetric 2D simulation data in a nearly steady state but with small perturbations in a sinusoidal form being added in the azimuthal direction. The mass accretion rate onto the black hole is ∼102LE/c2 in the underlying 2D simulation data, and the outflow rate is ∼10 LE/c2 (with LE and c being the Eddington luminosity and speed of light, respectively). We first confirm the emergence of clumpy outflow, which was discovered by the 2D RHD simulations, above the photosphere located at a few hundreds of Schwarzschild radii (rS) from the central black hole. As prominent 3D features we find that the clumps have the shape of a torn sheet, rather than a cut string, and that they are rotating around the central black hole with a sub-Keplerian velocity at a distance of ∼103 rS from the center. The typical clump size is ∼30 rS or less in the radial direction, and is more elongated in the angular directions, ∼ hundreds of rS at most. The sheet separation ranges from 50 to 150 rS. We expect stochastic time variations when clumps pass across the line of the sight of a distant observer. Variation timescales are estimated to be several seconds for a black hole with mass of ten to several tens of M⊙, in rough agreement with the observations of some ultra-luminous X-ray sources.
Churches as firms: An exploration of regulatory similarities
Authors: Patrikios Stratos , De Francesco Fabrizio 
Published: January 2018

AbstractRegulatory states manage religious activity within their jurisdiction in the same way they manage economic activity, in an alignment pattern that reflects institutionally embedded processes. Relying on regulatory institutional options to trace consistencies in the way a regime manages economic and religious activity, the article develops and tests theoretical accounts of the presence and content—in terms of comparative variation—of this alignment. The empirical setting, primarily OECD countries in recent decades, allows us to reverse a conventional causal view and treat religious regulation as causally embedded in the logic and practice of economic regulation. If reliance on regulation as a means of social control is bound by the same processes across domains, this may even suggest the existence of national cross-sectoral models of coordinating competition. The study elaborates a broad conceptualization of regulatory governance with potentially wide applicability.
Transient Receptor Potential Canonical Channel Blockers Improve Ventricular Contractile Functions After Ischemia/Reperfusion in a Langendorff-perfused Mouse Heart Model
Authors: Kojima Akiko , Fukushima Yutaka , Ito Yuki , Ding Wei-Guang , Kitagawa Hirotoshi , Matsuura Hiroshi 
Published: January 2018

Abstract:
Reperfusion of ischemic myocardium is accompanied by intracellular Ca2+ overload, leading to cardiac dysfunction. However, the mechanisms underlying intracellular Ca2+ overload have yet to be fully elucidated. The mechanism may involve the activation of store-operated Ca2+ entry, which is primarily mediated through the transient receptor potential canonical (TRPC) channels. This study was undertaken to examine the possible involvement of TRPC channels in the development of contractile dysfunction associated with reperfusion of ischemic myocardium using a mouse heart model. The functional expression of TRPC channels was confirmed in mouse ventricular myocytes using immunocytochemistry, Western blotting, and patch-clamp experiments. The left ventricular functions were assessed by measuring left ventricular end-diastolic pressure, left ventricular developed pressure, and its first derivatives in a Langendorff-perfused mouse heart subjected to 30 minutes of normothermic (37°C) global ischemia followed by 60 minutes of reperfusion. Under control conditions, left ventricular functions were deteriorated during reperfusion, which was significantly ameliorated by administration of the TRPC channel blockers 2-aminoethoxydiphenyl borate and La3+ during initial 5 minutes of reperfusion. Our findings suggest that TRPC channels are involved in mediating contractile dysfunction during reperfusion of ischemic myocardium and detect TRPC channels as a potential therapeutic target for preventing myocardial ischemia/reperfusion injury.
Diagnostic Accuracy of Coronary Computed Tomography Before Aortic Valve Replacement
Authors: Chaikriangkrai Kongkiat , Jhun Hye Yeon , Shantha Ghanshyam Palamaner Subash , Abdulhak Aref Bin , Tandon Rudhir , Alqasrawi Musab , Klappa Anthony , Pancholy Samir , Deshmukh Abhishek , Bhama Jay , Sigurdsson Gardar 
Published: January 2018

Purpose:
In aortic stenosis patients referred for surgical and transcatheter aortic valve replacement (AVR), the evidence of diagnostic accuracy of coronary computed tomography angiography (CCTA) has been limited. The objective of this study was to investigate the diagnostic accuracy of CCTA for significant coronary artery disease (CAD) in patients referred for AVR using invasive coronary angiography (ICA) as the gold standard.

Materials and Methods:
We searched databases for all diagnostic studies of CCTA in patients referred for AVR, which reported diagnostic testing characteristics on patient-based analysis required to pool summary sensitivity, specificity, positive-likelihood ratio, and negative-likelihood ratio. Significant CAD in both CCTA and ICA was defined by >50% stenosis in any coronary artery, coronary stent, or bypass graft.

Results:
Thirteen studies evaluated 1498 patients (mean age, 74 y; 47% men; 76% transcatheter AVR). The pooled prevalence of significant stenosis determined by ICA was 43%. Hierarchical summary receiver-operating characteristic analysis demonstrated a summary area under curve of 0.96. The pooled sensitivity, specificity, and positive-likelihood and negative-likelihood ratios of CCTA in identifying significant stenosis determined by ICA were 95%, 79%, 4.48, and 0.06, respectively. In subgroup analysis, the diagnostic profiles of CCTA were comparable between surgical and transcatheter AVR.

Conclusions:
Despite the higher prevalence of significant CAD in patients with aortic stenosis than with other valvular heart diseases, our meta-analysis has shown that CCTA has a suitable diagnostic accuracy profile as a gatekeeper test for ICA. Our study illustrates a need for further study of the potential role of CCTA in preoperative planning for AVR.
RNAi screening of the tyrosine kinome in primary patient samples of acute myeloid leukemia
Authors: Edwards David K. , Eryildiz Fatma , Tyner Jeffrey W. 
Published: January 2018

AbstractTargeted therapy has proven to be successful in improving outcomes across multiple cancer types. However, many challenges still remain for implementation of this strategy in most patient cohorts, especially with the challenges of identifying the specific mutations or abnormalities in a heterogeneous tumor that are functionally significant. Previously, we developed a functional screening assay, RNAi-assisted protein target identification (RAPID) technology, which evaluates the viability of tumor cells after exposure to siRNAs against members of the tyrosine kinome and NRAS/KRAS. Here, we publish the comprehensive results of this screen for 332 primary AML patient samples. Data from these screening efforts have already helped identify previously unknown therapeutic targets, and will continue to provide insights into better treatment strategies for these patients.
A contribution of FcγRIIIa cosignaling in TFHsubset development in Systemic Lupus Erythematosus
Authors: Chauhan Anil K 
Published: January 2018

AbstractBackgroundExpansion of follicular helper T cells (TFH) population occurs in systemic lupus erythematosus (SLE) and their numbers correlate with autoantibody titers. In this study, we sought to examine the role of ICs (FcγRIIIa costimulation) play in TFHcells development.MethodsWe examined the presence of blood TFHcells using multicolor flow analysis in SLE patientsin vivo. We then examined the development of these cellsin vitrousing plate-bound ICs. Performed differential expression analysis in cells activated via FcγRIIIa and compared to CD28 cosignaling.ResultsIn SLE patients PBMCs, CD4+gated T cells show IC binding and phosphorylated spleen tyrosine kinase (pSyk). These pSyk+cells express PD1, ICOS, IL-21, and Bcl6, the TFHpopulation markers.In vitroactivation from plate-bound ICs of human naïve CD4+T cells results in the differentiation of TFHlike cells phenotype. We show that FcγRIIIa-pSyk cosignaling in Bcl6+IL-21+cells drives the production of both IFN-γ(TFH1) and IL-17A (TFH17) production. TLR9 engagement by CpG ODN 2006 combined with FcγRIIIa costimulation of CD4+T cells augments, IL-17A, IL-21 production in Bcl6+T cells. FcγRIIIa cosignaling induced the overexpression of microRNAs that participate in TLR signaling and are associated with TFHcell differentiation. RNA-seq data reveal pathways that may contribute to the development of TFHcells and nucleic acid sensing.ConclusionOur results suggest a role for FcγRIIIa receptors in TFHdevelopment and a role for nucleic acid sensing in the expansion of TFHcells.
Inhibition of Hsp70 suppresses neuronal hyperexcitability and attenuates seizures by enhancing A-type potassium currents
Authors: Hu Fang , Zhou Jingheng , Lu Yanxin , Guan Lizhao , Wei Ning-ning , Huang Zhuo , Tang Yi-Quan , Wang KeWei 
Published: January 2018

ABSTRACTThe heat shock protein 70 (Hsp70) is upregulated in response to stress and has been implicated as a stress marker in temporal lobe epilepsy (TLE). However, whether Hsp70 plays a pathologic or protective role in TLE remains unclear. Here we report that Hsp70 exerts an unexpected deleterious role in kainic acid (KA)-induced seizures, and inhibition of Hsp70 suppresses neuronal hyperexcitability and attenuates both acute and chronic seizures via enhancing A-type potassium currents primarily formed by Kv4 α-subunits and auxiliary KChIPs. Proteosomal degradation of Kv4-KChIP4a channel complexes is enhanced by Hsp70, which can be reversed by the Hsp70 inhibitors, 2-phenylethynesulfonamide (PES) and VER-155008 (VER). In cultured hippocampal neurons, either PES or VER can increase A-type Kv4 current to suppress neuronal hyperexcitability. Mechanistically, Hsp70-CHIP complexes directly bind to the N-terminus of auxiliary KChIP4a and target Kv4-KChIP4a complexes to the proteasome. Our findings reveal a previously unrecognized role of Hsp70 in mediating degradation of Kv4-KChIP4a complexes and regulating neuronal excitability, thus highlighting a therapeutic potential for hyperexcitability-related neurological disorders through Hsp70 inhibition.
Determining rewiring effects of alternatively spliced isoforms on protein-protein interactions using a computational approach
Authors: Narykov Oleksandr , Johnson Nathan , Korkin Dmitry 
Published: January 2018

AbstractThe critical role of alternative splicing (AS) in cell functioning has recently become apparent, whether in studying tissue-or cell-specific regulation, or understanding molecular mechanisms governing a complex disorder. Studying the rewiring, or edgetic, effects of alternatively spliced isoforms on protein interactome can provide system-wide insights into these questions. Unfortunately, high-throughput experiments for such studies are expensive and time-consuming, hence the need to develop an in-silico approach. Here, we formulated the problem of characterization the edgetic effects of AS on protein-protein interactions (PPIs) as a binary classification problem and introduced a first computational approach to solve it. We first developed a supervised feature-based classifier that benefited from the traditional features describing a PPI, the problem-specific features that characterized the difference between the reference and alternative isoforms, and a novel domain interaction potential that allowed pinpointing the domains employed during a specific PPI. We then expanded this approach by including a large set of unlabeled interactomics data and developing a semi-supervised learning method. Our method called AS-IN (Alternatively Splicing INteraction prediction) Tool was compared with the state-of-the-art PPI prediction tools and showed a superior performance, achieving 0.92 in precision and recall. We demonstrated the utility of AS-IN Tool by applying it to the transcriptomic data obtained from the brain and liver tissues of a healthy mouse and western diet fed mouse that developed type two diabetes. We showed that the edgetic effects of differentially expressed transcripts associated with the disease condition are system-wide and unlikely to be detected by looking only at the gene-specific expression levels.
Employee learning in high-contact service industries
Authors: Yee Rachel W.Y. , Lee Peter K.C. , Yeung Andy C.L. , Cheng T.C.E. 
Published: January 2018

PurposeEmployee learning is imperative in the dynamic service environment; yet, much is still unknown about its strategic importance. The purpose of this paper is to extend the understanding of learning by focusing on the strategic importance of learning goal orientation (LGO) in customer-contact employees in service industries characterized with high customer contact.Design/methodology/approachThis paper adopts the multi-method approach by conducting two studies in the high-contact service sector. Study 1 is a large-scale, multiple-respondent survey that investigates the associations between LGO and its antecedents and performance outcomes. To supplement study 1, study 2 embraces case studies that identify the managerial supportive practices and outcomes of customer-contact employees’ learning behaviors.FindingsThe results of study 1 demonstrate that employees’ affective organizational commitment does not yield higher-quality services unless the service employees are learning oriented. The findings of study 1 also indicate that management commitment to service quality has positive effects on both LGO and affective organizational commitment. In study 2, the results reveal the practical methods that managers can employ to effectively promote such activities.Originality/valueThis research offers novel insights into research on learning by showing the strategic importance of LGO to enhancing high-contact service firms’ performance and the practical means of fostering LGO in customer-contact employees.
Generative tools enhance creative and ethical research with children
Authors: Sanders Alane 
Published: January 2018

Purpose
Qualitative researchers working with young people consistently face challenges in trying to ethically gain insight into their inner thoughts and worlds. The purpose of this paper is to examine how the use of generative tools in conjunction with qualitative interviewing with young people can enhance creativity and reflexivity, while mitigating adult-child power dynamics.

Design/methodology/approach
This paper draws upon ethnographic research conducted by the author examining the interplay between emotion, communication, and schooling at a public high school. Participant observation, use of generative tools to make collages representing each student’s experience, and in-depth interviews guided by the student-created visuals were triangulated to more fully understand the students’ experiences.

Findings
Generative tools foster reflexivity in both researcher and participants, lesson adult-child power dynamic concerns, and foster creativity without the requirement of drawing ability. Integrating the collaging process into in-depth interviews enabled students to privilege their primary thoughts, experiences, and concerns related to the issues being studied, mitigating concerns over adults overpowering and controlling the focus of the interview.

Originality/value
Generative tools can complement and enhance time-honored qualitative methods to alleviate ongoing concerns about ethical and accurate research with young people. Researchers are encouraged to embrace creative methods to engage young people in ethical and thoughtful reflection on and sharing of their experiences. Creative methods are also useful in empowering young people to imagine their world otherwise creating new possibilities for the future.
Regulatory Constraints on Public Sector Innovation: A Case Study on Queensland's Independent Public School Program
Authors: Lane Aaron M. 
Published: January 2018

AbstractInnovation is essential to the improvement of public sector services, yet restrictive regulations may constrain this process. This paper draws on the school autonomy literature to advance our understanding of the effect of regulatory constraints on public sector innovation, using Queensland's Independent Public Schools (IPS) program as a case study and example of regulatory change. The IPS program commenced operation in 2013. Schools are accepted into the program through an expression of interest application. Application forms require individual schools to outline the ‘innovative educational programs or practices’ the school will be able to implement if it is accepted as an IPS (Innovation Question). A textual content analysis was undertaken of the Innovation Question for a total of 127 successful applications in the 2013, 2014 and 2015 rounds. Coding was developed based on the Schumpeterian forms of innovation. Overall the results show that the Queensland IPS initiative will foster innovation according to principal's perceptions about the innovative practices that they will be able to implement as an IPS. The paper finds that the current centralised service delivery model is constraining innovation with respect to staffing flexibility, school partnerships, leasing and licensing of facilities and in managing school buildings, facilities and infrastructure.