bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complications and Failure of Endovenous Laser Ablation and Radiofrequency Ablation Procedures in Patients With Lower Extremity Varicose Veins in a 5-Year Follow-Up
Authors: Woźniak Witold , Mlosek R. Krzysztof , Ciostek Piotr 
Published: September 2016

Introduction: Thermal ablation techniques have gradually replaced Babcock procedure in varicose vein treatment. Aim: A comparative quantitative–qualitative analysis of complications and failure of endovenous laser ablation (EVLA) and radiofrequency ablation (RFA) in a 5-year follow-up. Materials and Methods: One hundred ten adult participants with varicose veins clinical grade C2 to C6, treated for isolated great saphenous vein (GSV) or small saphenous vein (SSV) insufficiency in a single lower extremity in 2009 to 2010, were enrolled and subdivided into EVLA (n = 56) and RFA (n = 54) groups. Both groups were compared for demography, disease stage, affected veins, perioperative, and postoperative complications as well as treatment efficacy. Results: The perioperative and postoperative complications were statistically insignificant. Treatment efficacy, expressed as the number of participants with recurrent varicosity and recanalization, was comparable in both groups. The clinically significant recanalization rate was 3.6% and 5.6% in EVLA and RFA groups, respectively. Conclusion: Endovenous laser ablation and RFA for the management of lower extremity varicose vein offer comparable efficacy and safety in a 5-year follow-up.
Surgical Preparation for Articular Cartilage Regeneration in the Osteoarthritic Knee Joint
Authors: Mika Joerg , Clanton Thomas O. , Ambrose Catherine G. , Kinne Raimund W. 
Published: September 2016

Purpose: Autologous chondrocyte implantation (ACI) is a treatment option even in early osteoarthritis (OA). Surgical preparation for ACI should avoid penetration of the subchondral bone plate to prevent hemorrhage, fibrin clot formation, and subsequent activation of the inflammatory response. Hypothesis: Current surgical procedures with ring curettes preserve the integrity of the subchondral bone plate, even in patients with OA. Methods: Subchondral femoral bone plates ( n = 40) of OA knees undergoing total knee arthroplasty were prepared in vivo using standard, non–brute-force debridement for ACI. To approach regular wear/early OA, only cartilage with maximally grade 3A International Cartilage Repair Society score was prepared. Effects were analyzed by light microscopy. Results: In 87.5% of the specimens (35/40), standard debridement did not violate the tide mark, except for occasional minor openings with a smooth edge (diameter approximately 20 µm). In contrast, 5/40 samples (12.5%) showed one large area with a missing bone plate and an open bone marrow space. Twenty-eight specimens (70%) showed at least remnants of uncalcified cartilage. Conclusion: On the basis of size/fine structure, the occasional minor openings are likely due to increased vascular penetration through the tide mark in the pathologically altered bone-cartilage interface in OA. The consequences of limited hemorrhage through minor openings or selected large defects following in vivo debridement are still unknown. Thus, standard debridement appears suitable for cartilage regeneration even in OA defects.
Validation of the efficacy of the prognostic factor score in the Japanese severity criteria for severe acute pancreatitis: A large multicenter study
Authors: Ikeura Tsukasa , Horibe Masayasu , Sanui Masamitsu , Sasaki Mitsuhito , Kuwagata Yasuyuki , Nishi Kenichiro , Kariya Shuji , Sawano Hirotaka , Goto Takashi , Hamada Tsuyoshi , Oda Takuya , Yasuda Hideto , Ogura Yuki , Miyazaki Dai , Hirose Kaoru , Kitamura Katsuya , Chiba Nobutaka , Ozaki Tetsu , Yamashita Takahiro , Koinuma Toshitaka , Oshima Taku , Yamamoto Tomonori , Hirota Morihisa , Yamamoto Satoshi , Oe Kyoji , Ito Tetsuya , Iwasaki Eisuke , Kanai Takanori , Okazaki Kazuichi , Mayumi Toshihiko 
Published: September 2016

BackgroundThe Japanese severity criteria for acute pancreatitis (AP), which consist of a prognostic factor score and contrast‐enhanced computed tomography grade, have been widely used in Japan.ObjectiveThis large multicenter retrospective study was conducted to validate the predictive value of the prognostic factor score for mortality and complications in severe AP patients in comparison to the Acute Physiology and Chronic Health Evaluation II (APACHE II) score.MethodsData of 1159 patients diagnosed with severe AP according to the Japanese severity criteria for AP were retrospectively collected in 44 institutions.ResultsThe area under the curve (AUC) for the receiver‐operating characteristic curve of the prognostic factor score for predicting mortality was 0.78 (95% confidence interval (CI), 0.74–0.82), whereas the AUC for the APACHE II score was 0.80 (95% CI, 0.76–0.83), respectively. There were no significant differences in the AUC for predicting mortality between two scoring systems. The AUCs of the prognostic factor scores for predicting the need for mechanical ventilation, the development of pancreatic infection, and severe AP according to the revised Atlanta classification were 0.84 (95% CI, 0.81–0.86), 0.73 (95% CI, 0.69–0.77), and 0.83 (95% CI, 0.81–0.86), respectively, which were significantly greater than the AUCs for the APACHE II score; 0.81 (95% CI, 0.78–0.83) for the need for mechanical ventilation (p  = 0.03), 0.68 (95% CI, 0.63–0.72) for the development of pancreatic infection (p  = 0.02), and 0.80 (95% CI, 0.77–0.82) for severe AP according to the revised Atlanta classification (p  = 0.01).ConclusionThe prognostic factor score has an equivalent ability for predicting mortality compared with the APACHE II score. Regarding the ability for predicting the development of severe complications during the clinical course of AP, the prognostic factor score may be superior to the APACHE II score.
Comparison of open and robotic nephron sparing surgery: a single centre experience
Authors: Jelley Clare R , Kurukulaarachchi Kurukula ASH , Forster Luke , Bardgett Harry , Singh Rajindra , Addla Sanjai K 
Published: September 2016

Objective: To compare robotic partial nephrectomy (RAPN) with open partial nephrectomy (OPN) to assess efficacy and impact of learning curve. Methods: From 2010 to 2015 159 patients had a partial nephrectomy (82 OPN and 77 RAPN). All data were collected prospectively. We compared the demographics, peri and postoperative outcomes. Results: Mean age was 60 years in both groups; 59% of patients were men. Tumour size was larger in the open group (34 mm vs 30 mm; P<0.08), but RENAL nephrometry scores greater than 6 were comparable (over 60%). Mean ischaemic time was longer in the RAPN group (18 vs 13 minutes; P<0.04) but complication rates were similar. The RAPN cohort had a reduced estimated blood loss (100 ml vs 300 ml; P<0.01) and shorter median hospital stay (2 vs 5 days; P<0.01). Only two patients in each group were margin positive. The RAPN cohort demonstrated reduced estimated blood loss and a trend towards more complex tumours with increasing learning curve. Conclusion: RAPN is superior to OPN in terms of reduced hospital stay and estimated blood loss without compromising oncological outcomes. This service can be delivered safely and effectively in a low to medium volume cancer centre; these results are similar to published figures from high volume international centres.
A picture is worth a thousand data points: an imagery dataset of paired shrub-open microsites within the Carrizo Plain National Monument
Authors: Noble Taylor J , Lortie Christopher J , Westphal Michael , Butterfield H. Scott 
Published: September 2016

Abstract

Background
Carrizo Plain National Monument (San Joaquin Desert, California, USA) is home to many threatened and endangered species including the blunt-nosed leopard lizard (Gambelia sila). Vegetation is dominated by annual grasses, and shrubs such as Mormon tea (Ephedra californica), which is of relevance to our target species, the federally listed blunt-nosed leopard lizard, and likely also provides key ecosystem services. We used relatively nonintrusive camera traps, or trail cameras, to capture interactions between animals and these shrubs using a paired shrub-open deployment. Cameras were placed within the shrub understory and in open microhabitats at ground level to estimate animal activity and determine species presence.

Findings
Twenty cameras were deployed from April 1st, 2015 to July 5th, 2015 at paired shrub-open microsites at three locations. Over 425,000 pictures were taken during this time, of which 0.4 % detected mammals, birds, insects, and reptiles including the blunt-nosed leopard lizard. Trigger rate was very high on the medium sensitivity camera setting in this desert ecosystem, and rates did not differ between microsites.

Conclusions
Camera traps are an effective, less invasive survey method for collecting data on the presence or absence of desert animals in shrub and open microhabitats. A more extensive array of cameras within an arid region would thus be an effective tool to estimate the presence of desert animals and potentially detect habitat use patterns.
Polypyrrole-incorporated conductive hyaluronic acid hydrogels
Authors: Yang Jongcheol , Choe Goeun , Yang Sumi , Jo Hyerim , Lee Jae Young 
Published: September 2016

Abstract

Background
Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not electrically conductive and thus their electrical communication with biological systems is limited.

Method
To create electrically conductive hydrogels, we fabricated composite hydrogels of hyaluronic acid and polypyrrole. In particular, we synthesized and used pyrrole-hyaluronic acid-conjugates and further chemically polymerized polypyrrole with the conjugates for the production of conductive hydrogels that can display suitable mechanical and structural properties.

Results
Various characterization methods, using a rheometer, a scanning electron microscope, and an electrochemical analyzer, revealed that the PPy/HA hydrogels were soft and conductive with ~ 3 kPa Young’s modulus and ~ 7.3 mS/cm conductivity. Our preliminary in vitro culture studies showed that fibroblasts were well attached and grew on the conductive hydrogels.

Conclusion
These new conductive hydrogels will be greatly beneficial in fields of biomaterials in which electrical properties are important such as tissue engineering scaffolds and prosthetic devices.
Abdominal obesity and cardiometabolic risk in children and adolescents, are we aware of their relevance?
Authors: Forkert Elsie C. O. , Rendo-Urteaga Tara , Nascimento-Ferreira Marcus Vinicius , de Moraes Augusto Cesar Ferreira , Moreno Luis A. , de Carvalho Heráclito Barbosa 
Published: September 2016

AbstractObesity prevalence has increased worldwide over the last decades and has reached alarming rates in low middle-income countries. Childhood has been affected by this epidemic, leading to premature dramatic health problems.Adipose tissue is currently considered as an endocrine organ modulating an inflammatory state and important metabolic processes (insulin resistance, hypertension, glucose intolerance) leading to consequences of the cardiovascular system. This situation may be worst if the excess of body fat distribution such as abdominal obesity (AO) is involved because it is associated with a more atherogenic risk profile determining the cardiometabolic risks mainly in children and adolescents.Hence, the knowledge regarding the association between AO and cardiometabolic factors aims to prevent and treat the obesity in this young population, avoiding early harmful consequences of adulthood health.
Age at onset of caloric restriction and its effects on the redox profile of the rat hippocampus
Authors: Pereira Cristiane , Nardin Patricia , de Souza Daniela Fraga , Grings Mateus , Leipnitz Guilhian , Gonçalves Carlos Alberto Saraiva , Schneider Augusto , Abib Renata Torres , Valle Sandra Costa , Helbig Elizabete 
Published: September 2016

Abstract
Background
The benefits of caloric restriction (CR) on the protection against age-related neurodegenerative diseases have been the subject of several studies. However, the effects of CR on the central nervous system are still poorly understood since most studies were carried out in mature animals. The present study aimed to investigate whether the age at onset of CR could differently affect the redox status of the rat hippocampus.

Methods
Thirty-two male Wistar rats at 35 days old (35d; n = 16) and 65 days old (65d; n = 16) were fed ad libitum or subjected to 30 % CR (n = 8 group/age) for 12 weeks. At the end of the experiment, the rats were euthanized, blood was collected, and the hippocampus was dissected for measuring the redox status.

Results
CR in 35d and 65d rats induced a 16 and 21 % reduction in body weight gain, respectively, compared to controls (p < 0.05). Urea, total cholesterol, triacylglycerol, HDL cholesterol, and LDL cholesterol concentrations were lower in CR 35d rats than in 35d controls (p < 0.05). No differences were detected between the CR groups and controls in the object recognition test (p > 0.05) and in superoxide dismutase activity, nitric oxide content, and lipid peroxidation levels (p > 0.05). However, glutathione peroxidase activity was higher (p < 0.0001) in 65d rats compared to that in 35d rats, and GSH content was higher (p < 0.05) in CR-fed rats compared to that in controls at both ages.

Conclusions
In conclusion, CR increased GSH content when started at both ages but did not affect the activity of antioxidant enzymes and the level of ROS in the hippocampus. In addition, CR did not induce any detrimental effects on memory and nutritional status when started in both 35d and 65d rats.
Methodical Approaches to Forming of Price Policy on Innovative Types of Production
Authors: Графова  , Grafova Galina , Графов  , Grafov Andrey , Аврашков  , Avrashkov Lyev , Шахватова  , Shakhvatova S. 
Published: September 2016

Th e article off ers a pricing technique on innovative products. Within the solution of this question classifi cation
of level of prices for innovative products is off ered, the fi nancial and economic base by its determination with indication
of specifi c evaluation methods is described.
Standardization of Audit of Entities of Public Sector of Economy
Authors: Ситнов  , Sitnov Alyeksyey 
Published: September 2016

Th e paper essentially generalizes and systematizes the views on audit of subjects of the state sector of the economy.
In the study the author outlined his views on the possibility of applying the standards of INTOSAI and the audit chamber
of the Russian Federation in the audit of these entities.
Option Pricing for a Jump-Diffusion Model with General Discrete Jump-Size Distributions
Authors: Fu Michael C. , Li Bingqing , Li Guozhen , Wu Rongwen 
Published: September 2016

We obtain a closed-form solution for pricing European options under a general jump-diffusion model that can incorporate arbitrary discrete jump-size distributions, including nonparametric distributions such as an empirical distribution. The flexibility in the jump-size distribution allows the model to better capture leptokurtic features found in real-world data. The model uses a discrete-time framework and leads to a pricing formula that is provably convergent to the continuous-time price as the discretization is increased. The solution is easy to implement with fast convergence properties. Numerical results illustrate the efficiency and accuracy of the proposed model and highlight its robustness and flexibility. This paper was accepted by Noah Gans, stochastic models and simulation.
The one-leg standing radiograph
Authors: Pinsornsak P. , Naratrikun K. , Kanitnate S. , Sangkomkamhang T. 
Published: September 2016

Objectives The purpose of this study was to compare the joint space width between one-leg and both-legs standing radiographs in order to diagnose a primary osteoarthritis of the knee. Methods Digital radiographs of 100 medial osteoarthritic knees in 50 patients were performed. The patients had undergone one-leg standing anteroposterior (AP) views by standing on the affected leg while a both-legs standing AP view was undertaken while standing on both legs. The severity of the osteoarthritis was evaluated using the joint space width and Kellgren-Lawrence (KL) radiographic classification. The t-test was used for statistical analysis. Results The mean medial joint space width found in the one-leg and in the both-legs standing view were measured at 1.8 mm and 2.4 mm, respectively (p < 0.001, 95% CI 0.5 to 0.7). 33%, 47.4% and 23.1% of the knees diagnosed with a KL grade of I, II and III in the both-legs standing views were changed to KL grade II, III and IV in the one-leg standing views, respectively. No changes for KL IV osteoarthritis diagnoses have been found between both- and one-leg standing views. Conclusions One-leg standing radiographs better represent joint space width than both-legs standing radiographs. 32% of both-legs standing radiographs have changed the KL grading to a more severe grade than that in the one-leg standing radiographs. Cite this article: P. Pinsornsak, K. Naratrikun, S. Kanitnate, T. Sangkomkamhang. The one-leg standing radiograph: An improved technique to evaluate the severity of knee osteoarthritis. Bone Joint Res 2016;5:436–441. DOI: 10.1302/2046-3758.59.BJR-2016-0049.R1.
Is impairment in cognitive inhibition in the acute phase of major depression irreversible? Results from a 10‐year follow‐up study
Authors: Årdal Guro , Hammar Åsa 
Published: September 2016

Objectives. Even though many studies demonstrate cognitive impairment in the acute phase of depression and several studies indicate that this impairment might be long lasting despite symptom reduction and recovery, there is a lack of longitudinal studies on this field with considerable follow‐up length. The aim of this study was to investigate whether the impairment observed in cognitive inhibition in the acute phase of depression is reversible or irreversible in a 10‐year follow‐up assessment. Design. A longitudinal study of 38 individuals, 19 with recurrent unipolar depression and 19 healthy controls matched for gender, age, and education were included in the study. Method. Cognitive inhibition was investigated using the Stroop test at three different occasions: acute phase, short‐term (6 months), and long‐term (10 years) follow‐up. Results. The results show that recurrent major depressive disorder patients have a long‐lasting impairment in inhibition as measured by the Stroop test in 10‐year follow‐up. Further there is high consistency in inner group performance suggesting that severe impairment in the acute phase of illness is associated with severe impairment 10 years later despite recovery in the patient group. Conclusions. The results show that impairment in cognitive inhibition is long lasting when present in the acute phase of recurrent depression. Impaired cognitive inhibition might be an irreversible vulnerability marker for recurrent depression.
Finding the Most Efficient Technology Transfer Route Using Dijkstra Algorithm to Foster Innovation: The Case of Essential Oil Developments in the Research Center for Chemistry at the Indonesian Institute of Sciences
Authors: Setiawan Arief Ameir Rahman , Sulaswatty Anny , Haryono Agus 
Published: September 2016

<p>Innovation is one of the most critical issues in research institutions which can be performed through certain routes within the technology transfer mechanism. As the demands of research implementation are increasing, a better mechanism should be deployed to foster innovation. This study will investigate the possibilities for technology transfer mechanism improvements by (i) identifying a number of steps required for innovation; (ii) measuring the efficiency of each step; and (iii) exploring the most efficient routes to innovate through the Dijkstra algorithm. Cases of research on essential oils and derivatives in the Research Center for Chemistry (RCC) of the Indonesian Institute of Sciences (LIPI) will be examined as the working example for the study. As a result of this study, a model containing a recommended sequence for the most efficient steps to innovation can be proposed. Using the proposed model, the efficiency rate of the technology transfer mechanism was increased twice, suggesting the possibility of stimulating innovation performance.</p>
IMPROVING “JUST-IN-TIME, JUST-IN-SEQUENCE” DELIVERY IN FIRST-TIER SUPPLIERS
Authors: Bautista Joaquin , Fortuny-Santos Jordi 
Published: September 2016

This paper presents an action-research project aiming at improving the performance of “just-in-time, just-in-sequence” auto parts manufacturing and delivery in three tier-1 suppliers of the Nissan plant in Barcelona. This research was conducted at the Barcelona School of Engineering (ETSEIB) and promoted by the Nissan factory in Barcelona. In this paper, first, the concept of synchronous manufacturing is explored. After several improvement ideas are spotted within the Nissan plant, the paper focuses on the suppliers. An intervention approach is proposed. Suppliers are categorized and selected suppliers are analyzed (by means of three case studies, each one corresponding to a different type of supplier). This research contributes to understanding how synchronous manufacturing and delivery can be extended to suppliers and the existing drawbacks. The critical variables in synchronous manufacturing and delivery and the relations between them are identified in a conceptual model termed the M-S Model. Implications for suppliers are derived, allowing us to improve the performance of the whole synchronous manufacturing system. A piece of software is developed to help companies schedule a smooth flow of components, making synchronous manufacturing easier. Results may help decision makers develop a supply management system, including policies, procedures and the necessary resource deployment.
INDUSTRIALISASI PERIKANAN DALAM PENGEMBANGAN WILAYAH DI JAWA TIMUR
Authors: Huda Hakim Miftakhul , Purnamadewi Yeti Lis , Firdaus Muhammad 
Published: September 2016

Disparity of development, poverty and unemployment is one of the main problems of East Java Province. On the other hand East Java province has great potential fishery. This study aims to analyze the role of the fisheries sub-sector in the regional economy of East Java province, knowing the factors that influence the fisheries development and arrange the fisheries development strategy in East Java province. Processing data using descriptive analysis, input-output (IO) and multiple linear regression. Fish processing subsector provide the largest multipliers of employment, output and value added among fisheries subsector. Inland fisheries subsector provide the largest of total linkages between fishery subsector, whereas the marine fisheries subsector have the largest of output value among the fishery subsector. Labor and maritime affairs and fisheries budget have a positive influence on the development of fisheries. Fisheries development strategy should be carried out simultaneously between marine, inland and fisheries processing. Fisheries industrialization strategy is expected to increase the value added of fisheries and reduce the disparity of development, poverty and unemployment.