bluuebunny/crossref_metadata_2025_split huggingface dataset:
Set AHDriFT: Applying game cameras to drift fences for surveying herpetofauna and small mammals
Authors: Martin Scott A. , Rautsaw Rhett M. , Robb Frank , Bolt M. Rebecca , Parkinson Christopher L. , Seigel Richard A. 
Published: September 2017

ABSTRACTThe use of game cameras by wildlife biologists and managers to survey wildlife, particularly medium‐ and large‐bodied mammals, has increased dramatically. Previous attempts to survey small mammals and ectotherms have had limited detection success or were focused solely on a single species. We describe the Adapted‐Hunt Drift Fence Technique (AHDriFT), which combines commercially available game cameras and traditional drift fences to survey reptiles, amphibians, and small mammals. Across 4,502 trap‐nights at the Merritt Island National Wildlife Refuge, Florida, USA (Jun 2014 to Jun 2015), we recorded images for 2,523 unique vertebrate detections (2% unidentifiable) averaging 0.56 unique triggers/night. Using AHDriFT enables long‐duration surveys with high detectability while minimizing observer time. Guide‐boards increased terrestrial vertebrate image capture at minimal cost. During 1 year of usage, no mortality was documented using this camera‐trap system and field time was reduced by 95%, requiring only monthly visits of approximately 3 hr for 9 fence arrays to download images from the camera systems, compared with pitfall or funnel traps that require at least daily monitoring. © 2017 The Wildlife Society.
The Met Needs for Pediatric Surgical Conditions in Sierra Leone: Estimating the Gap
Authors: Burgos Carmen Mesas , Bolkan Håkon Angell , Bash‐Taqi Donald , Hagander Lars , Von Screeb Johan 
Published: September 2017

AbstractBackgroundIn low‐ and middle‐income countries, there is a gap between the need for surgery and its equitable provision, and a lack of proxy indicators to estimate this gap. Sierra Leone is a West African country with close to three million children. It is unknown to what extent the surgical needs of these children are met.AimTo describe a nationwide provision of pediatric surgical procedures and to assess pediatric hernia repair as a proxy indicator for the shortage of surgical care in the pediatric population in Sierra Leone.MethodsWe analyzed results from a nationwide facility survey in Sierra Leone that collected data on surgical procedures from operation and anesthesia logbooks in all facilities performing surgery. We included data on all patients under the age of 16 years undergoing surgery. Primary outcomes were rate and volume of surgical procedures. We calculated the expected number of inguinal hernia in children and estimated the unmet need for hernia repair.ResultsIn 2012, a total of 2381 pediatric surgical procedures were performed in Sierra Leone. The rate of pediatric surgical procedures was 84 per 100,000 children 0–15 years of age. The most common pediatric surgical procedure was hernia repair (18%), corresponding to a rate of 16 per 100,000 children 0–15 years of age. The estimated unmet need for inguinal hernia repair was 88%.ConclusionsThe rate of pediatric surgery in Sierra Leone was very low, and inguinal hernia was the single most common procedure noted among children in Sierra Leone.
Enrolling Genomics Research Participants through a Clinical Setting: the Impact of Existing Clinical Relationships on Informed Consent and Expectations for Return of Research Results
Authors: Berrios Courtney , James Cynthia A. , Raraigh Karen , Bollinger Juli , Murray Brittney , Tichnell Crystal , Applegate Carolyn D. , Bergner Amanda L. 
Published: September 2017

AbstractGenetic counselors working in a clinical setting may find themselves recruiting, enrolling, and returning results for genomic research, and existing clinical relationships with study participants may impact these research interactions. We present a qualitative study using semi‐structured interviews of participants enrolled in a genome sequencing/exome sequencing (GS/ES) study at the same institution where they receive clinical care. Interviews were coded for motivations to participate and expectations of this research. The interviews revealed common motivations for participation, including altruism and hope for benefit for themselves, family members, and/or others with their condition. Additionally, themes emerged related to unintentional influence based on trust of the clinical provider that recruited them to the study. Participant trust in the enrolling provider at times appeared to extend to the study team to decide which research results to return and to do so in an appropriate format. Participants also based expectations for research results return on previous clinical genetic testing experiences, which may or may not be realistic depending on study design. It is imperative that genetic counselors enrolling patients into research studies be aware of the potential influence of their clinical relationship on potential subjects, be transparent about their role on the study team, and help set expectations about the study process, including results return.
Toward common mechanisms for risk factors in Alzheimer's syndrome
Authors: Medina Miguel , Khachaturian Zaven S. , Rossor Martin , Avila Jesús , Cedazo‐Minguez Angel 
Published: September 2017

AbstractThe global strategic goal of reducing health care cost, especially the prospects for massive increases due to expanding markets for health care services demanded by aging populations and/or people with a wide range of chronic disorders‐disabilities, is a complex and formidable challenge with many facets. Current projections predict marked increases in the demand for health driven by both the exponential climb in the prevalence of chronic disabilities and the increases in the absolute numbers of people in need of some form of health care. Thus, the looming predicament for the economics of health care systems worldwide mandates the formulation of a strategic goal to foster significant expansion of global R&D efforts to discover and develop wide‐ranging interventions to delay and/or prevent the onset of chronic disabling conditions. The rationale for adopting such a tactical objective is based on the premise that the costs and prevalence of chronic disabling conditions will be reduced by half even if a modest delay of 5 years in the onset of disability is obtained by a highly focused multinational research initiative. Because of the recent history of many failures in drug trials, the central thesis of this paper is to argue for the exploration‐adoption of novel mechanistic ideas, theories, and paradigms for developing wide range and/or types of interventions. Although the primary focus of our discussion has been on biological approaches to therapy, we recognize the importance of emerging knowledge on nonpharmacological interventions and their potential impact in reducing health care costs. Although we may not find a drug to cure or prevent dementia for a long time, research is starting to demonstrate the potential contributes of nonpharmacological interventions toward the economics of health care in terms of rehabilitation, promoting autonomy, and potential to delay institutionalization, thus promoting healthy aging and reductions in the cost of care.
A system-wide solution to antidote stocking in emergency departments: the Nova Scotia antidote program
Authors: Murphy Nancy G. , Bona D. Ruth , Hurley Theresa A. 
Published: September 2017

ABSTRACTObjectiveInadequate stocking of essential antidotes in hospitals is an internationally documented problem. A concrete and sustainable system-wide solution for easy access to antidotes in emergency departments (EDs) was developed and implemented in Nova Scotia, Canada.MethodsAntidote stocking guidelines and a systemwide antidote management strategy were established. A standardized collection of antidotes housed in highly visible containers in provincial EDs was implemented for timely access. Antidote-specific online administration guidelines were developed. Using the poison centre for surveillance, the antidote program maintained a database of antidote utilization patterns; 11 years of data were available for analysis.Results2/2 (100%) tertiary care, 9/9 (100%) regional EDs, and 21/25 (84%) community EDs in Nova Scotia stock antidote kits, for an overall compliance rate of 32/36 (89%). A total of 678 antidotes (excluding N-acetylcysteine) were used for 520 patients. The distribution of antidote use by hospital type was 99/678 (14.6%) at community hospitals, 379/678 (55.9%) at regional hospitals, and 200/678 (29.5%) at tertiary care hospitals. The five most commonly used antidotes were: naloxone 143/678 (21.1%), fomepizole 111/678 (16.4%), glucagon 94/678 (13.9%), calcium 70/678 (10.3%), and sodium bicarbonate 67/678 (9.9%). Of the 520 patients in whom antidotes were used, death occurred in 3% (15/520), major outcomes in 35% (183/520), and moderate outcomes in 39% (205/520).ConclusionThe Nova Scotia Antidote Program demonstrates that a solution to inadequate antidote stocking is achievable and requires a system-wide approach with ongoing maintenance and surveillance. The frequency and distribution of antidote usage documented in this program supports the need for enhancement of emergency preparedness. The poison centre and hospital pharmacies are crucial to surveillance and maintenance of this program.
It’s Your Job to Save Me: The Union of Canadian Correctional Officers and the Death of Ashley Smith
Authors: Balfour Gillian 
Published: September 2017

Abstract
The death of Ashley Smith represents the first time in Canadian legal history that correctional officers were criminally charged in the death of a prisoner under the care of the state. In response to these unprecedented charges, the Union of Canadian Correctional Officers (UCCO) mounted a highly public campaign in defense of the officers. In this article, I review UCCO’s media statements following Smith’s death, submissions to various government review committees, and the current Global Agreement between UCCO and Correctional Service Canada (CSC) regarding federally sentenced women. I suggest these narratives work to reproduce administrative segregation as necessary to manage “troubled young women” who are constituted as an unsafe working condition for officers. I highlight the failure of UCCO to influence government policy, unlike the effective success of unions in the United States, and I challenge the place of UCCO in Canada’s trade union movement.
Impact of Discontinuing Contact Precautions for MRSA and ESBLE in an Intensive Care Unit: A Prospective Noninferiority Before and After Study
Authors: Renaudin Laurie , Llorens Mathieu , Goetz Christophe , Gette Sébastien , Citro Vincente , Poulain Sylvia , Vanson Marie-Laure , Sellies Jocelyne 
Published: September 2017

OBJECTIVETo compare incidence densities of methicillin-resistant Staphylococcus aureus (MRSA) or extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBLE) acquisition in the intensive care unit (ICU) before and after discontinuation of contact precautions (CP) and application of standard precautions (SP).DESIGNProspective noninferiority before-and-after study comparing 2 periods: January 1, 2012, to January 31, 2014 (the CP period) and February 1, 2014, to February 29, 2016 (the SP period).SETTINGA 16-bed polyvalent ICU in France with only single-bed rooms with dedicated equipment and reusable medical devices.PATIENTSAll patients admitted to the ICU during the CP and SP periods were included: 1,547 and 1,577 patients, respectively.METHODSIncidence densities of ICU-acquired MRSA or ESBLE were determined per 1,000 patient days. Other studied factors included (1) patient characteristics, (2) incidence densities of MRSA or ESBLE carried at admission, (3) compliance with hand hygiene protocols, and (4) antibiotic consumption.RESULTSIncidence densities of ICU-acquired MRSA were 0.82 (95% confidence interval [CI], 0.31–1.33) and 0.79 (95% CI, 0.30–1.29) per 1,000 patient days during the CP and SP periods, respectively. For ESBLE, values were 2.7 (95% CI, 1.78–3.62) and 2.06 (95% CI, 1.27–2.86) per 1,000 patient days. These rates were significantly nonsuperior during the SP period compared to CP period, with a margin of 1 per 1,000 patient days for both MRSA (P=.002) and ESBLE (P=.004). Other factors were comparable during the 2 periods. Only ESBLE carried at admission was inferior during the SP period. We observed a high level of compliance to hand hygiene protocols.CONCLUSIONSDiscontinuing CP did not increase acquired MRSA and ESBLE in our ICU with single rooms with dedicated equipment, strict application of hand hygiene, medical and paramedical leadership, and good antibiotic stewardship.Infect Control Hosp Epidemiol 2017;38:1342–1350
Optimization on the Performance of a Precision Flank-Locking Locknut Considering the Machining and Operational Parameters
Authors: Chen C. M. , Lee C. Y. 
Published: September 2017

AbstractIn this study, the anti-loosening characteristics of a precision flank-locking locknut fabricated under various machining processes and tested in different dynamic environments were investigated. The control parameters considered include the tightening torque and thread pitch of the set screw, machining process on the end plane of locknut, and vibration amplitude and frequency of dynamic loading in service, etc. Their sensitivities on the axial force ratio and anti-loosening ratio of the locknut were evaluated using Taguchi method. It was found that the pretension of locknut, the tightening torque and the pitch of set screw, and the machining process of the nut's end plane were the significant control parameters for the anti-loosening performance of the locknut. Moreover, the results of experimental measurements were employed in the regression fit on the performance of the locknut. The regression model was able to predict the anti-loosening ratio with 4.42% average error comparing with the measurements. Furthermore, the optimized design of the locknut through the Taguchi method was able to increase the axial force ratio and anti-loosening ratio by 20.4% and 16.8%, respectively, comparing with standard locknut.
A Randomised Controlled Trial Evaluating the Effectiveness and Tolerability of Step-up and Step-down Varenicline Therapy for Smoking Cessation: A Study Protocol
Authors: Drovandi Aaron D. , Teague Peta-Ann , Glass Beverley D. , Malau-Aduli Bunmi 
Published: September 2017

Background: Varenicline remains the most effective medication for smoking cessation; however, discontinuation as a result of adverse events negatively impacts medication adherence, and the likelihood of a quit attempt being successful. Post-treatment cravings and withdrawal symptoms may also occur, increasing the likelihood of treatment failure, due to lapse and relapse after achieving initial abstinence. This protocol details a trial investigating changes in the effectiveness and tolerability of varenicline, when an extended step-up and step-down regimen are used.Methods: A phase four, randomised, double-blinded, placebo-controlled single-centre study with a treatment period of 16 weeks, and follow-up period of 12 weeks will be conducted. Up to 201 participants will be enrolled and allocated in a 1:1:1 ratio to a placebo-matching control group, step-up, or step-down intervention group, all receiving behavioural counselling and quitting advice. Participants will be contacted weekly during treatment and fortnightly during follow-up. Eligible participants are smokers over 18 years old, willing to quit smoking, are able to attend clinic visits, and have no uncontrolled or serious medical issues. Primary outcome measures are comparisons of biochemically confirmed continuous abstinence rates, 7-day point prevalence abstinence rates, and the frequency, severity and duration of adverse events, cravings and withdrawal symptoms. Secondary outcome measures are participant adherence to the study medication throughout treatment, and comparisons of changes in smoking satisfaction and reward. Effects of each regimen on smoking cessation will be assessed by logistic regression, with survival analyses used for a more precise estimate of when cessation occurs. Primary endpoints will then be compared using a general linear model. Australian New Zealand Clinical Trials Registry: ACTRN12616000802404p
The Kinematics of Quasar Broad Emission Line Regions Using a Disk-Wind Model
Authors: Yong Suk Yee , Webster Rachel L. , King Anthea L. , Bate Nicholas F. , O’Dowd Matthew J. , Labrie Kathleen 
Published: September 2017

AbstractThe structure and kinematics of the broad line region in quasars are still unknown. One popular model is the disk-wind model that offers a geometric unification of a quasar based on the viewing angle. We construct a simple kinematical disk-wind model with a narrow outflowing wind angle. The model is combined with radiative transfer in the Sobolev, or high velocity, limit. We examine how angle of viewing affects the observed characteristics of the emission line. The line profiles were found to exhibit distinct properties depending on the orientation, wind opening angle, and region of the wind where the emission arises.At low inclination angle (close to face-on), we find that the shape of the emission line is asymmetric, narrow, and significantly blueshifted. As the inclination angle increases (close to edge-on), the line profile becomes more symmetric, broader, and less blueshifted. Additionally, lines that arise close to the base of the disk wind, near the accretion disk, tend to be broad and symmetric. Single-peaked line profiles are recovered for the intermediate and equatorial wind. The model is also able to reproduce a faster response in either the red or blue sides of the line profile, consistent with reverberation mapping studies.
Conservation implications for the Himalayan wolf Canis (lupus) himalayensis based on observations of packs and home sites in Nepal
Authors: Werhahn Geraldine , Kusi Naresh , Sillero-Zubiri Claudio , Macdonald David W. 
Published: September 2017

AbstractWe provide insights into pack composition and den site parameters of the Himalayan wolf Canis (lupus) himalayensis based on observations of free-ranging wolves in three study areas in Nepal. We combine this with a social survey of the local Buddhist communities regarding human–carnivore conflict, to draw inferences for conservation practice in the Nepalese Himalayas. We recorded eight wolf packs (with an average composition of two adults and three pups), and found five home sites in high-altitude shrubland patches within alpine grasslands at 4,270–4,940 m altitude. There was a spatial–temporal overlap of wolf home sites and livestock herding during spring and summer, which facilitated human–wolf conflict. The litters of three out of five wolf packs found in Dolpa during 2016 were killed by local people in the same year. In Nepal compensation is offered for depredation by snow leopards Panthera uncia, with associated lowering of negative attitudes, but not for depredation by wolves. We recommend the implementation of financial and educational conservation schemes for all conflict-causing carnivores across the Himalayan regions of Nepal.
Why are psychotic experiences associated with self-injurious thoughts and behaviours? A systematic review and critical appraisal of potential confounding and mediating factors
Authors: Hielscher E. , DeVylder J. E. , Saha S. , Connell M. , Scott J. G. 
Published: September 2017

AbstractPsychotic experiences (PEs), including hallucination- and delusion-like experiences, are robustly associated with self-injurious thoughts and behaviours (SITB) in the general population. However, it remains unclear as to why there is an association. The purpose of this systematic review was to elucidate the role of other factors that influence the association between PEs and SITB and, in doing so, highlight potential mechanisms underlying the relationship. A search of electronic international databases was undertaken, including PubMed, PsycINFO and EMBASE, and eligible studies were grouped according to seven confounder categories: sociodemographics, mental disorders, alcohol and substance use, environmental, psychological, intervention and family history/genetic factors. The systematic search strategy identified 41 publications reporting on 1 39 427 participants from 16 different countries. In the majority of studies, where adjustment for other variables occurred, the association between PEs and SITB persisted, suggesting PEs have an independent role. Common mental disorders, psychological distress and negative environmental exposures explained a substantial amount of the variance and therefore need to be considered as potential underlying mechanisms. There was high variability in the variables adjusted for in these studies, and so the question still remains as to whether the association between PEs and self-harm/suicidality can be attributed (fully or in part) to confounding and mediating factors or directly causal mechanisms. Regardless of causality, the now extensive literature reporting an association between these two clinical phenomena supports the broad usefulness of PEs as an indicator of risk for SITB.
Trait and facet-level predictors of first-onset depressive and anxiety disorders in a community sample of adolescent girls
Authors: Goldstein Brandon L. , Kotov Roman , Perlman Greg , Watson David , Klein Daniel N. 
Published: September 2017

AbstractBackgroundIndividual differences in neuroticism, extraversion, and conscientiousness are associated with, and may predict onset of, internalizing disorders. These general traits can be parsed into facets, but there is a surprising paucity of research on facet risk for internalizing disorders. We examined general traits and facets of neuroticism, extraversion, and conscientiousness in predicting first onsets of depressive and anxiety disorders.MethodsA community sample of 550 adolescent females completed general and facet-level personality measures and diagnostic interviews. Interviews were re-administered 18 months later.ResultsFirst onsets of depressive disorders were predicted by neuroticism, extraversion, and conscientiousness. Facets predicting first onset of depression included depressivity (neuroticism facet) and lower positive emotionality and sociability (extraversion facets). First onsets of generalized anxiety disorder (GAD) were predicted by neuroticism, and particularly the facet of anxiousness. First onsets of social phobia were predicted at the facet level by anxiousness. First onsets of specific phobia were predicted by neuroticism, low conscientiousness, and all neuroticism facets. In multivariate analyses, first onsets of depression were uniquely predicted by depressivity, and onsets of GAD and social phobia were uniquely predicted by anxiousness over and above the general trait of neuroticism.ConclusionsGeneral traits predict first onsets of depressive and anxiety disorders. In addition, more specific associations are evident at the facet level. Facets can refine our understanding of the links between personality and psychopathology risk, and provide finer-grained targets for personality-informed interventions.