bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regimes of transcultural assemblage: Erased histories and forgotten boundaries in a festive shopping mall installation
Authors: Wu Jasper Zhao Zhen , Hiramoto Mie , Theng Andre Joseph 
Published: October 2024

Abstract
This article explores relations between transcultural processes and historical boundaries. Drawing on the Deleuzo-Guattarian concept of assemblage, it examines the selection and organisation of cultural elements in a Japanese-styled Chinese New Year installation at a Hong Kong shopping mall. The article presents three affective regimes produced in this transcultural assemblage: New Year festivity, simulated tourism, and partial historicity. We argue that these regimes are regulated in the processes of erasure (the selective blockage of competing lineages of rituals, traditions, and spaces) and forgetting (the process evoking creative re-organisation of semiotic boundaries between cultural elements selected into the transcultural assemblage). This article suggests two implications. First, transculturality is not only the dialogic transgression and creation of boundaries but also the selection and regulation of cultural elements in an assemblage. Second, historical boundaries are not sidestepped but are regulated by the partial blockage through erasure and re-organisation through forgetting in affective regimes. (Transculturality, assemblage, affective regime, erasure, forgetting, Hong Kong)
Lydian pottery in the Roman tradition: An archaeometric study of production at Sardis
Authors: Rautman Marcus , Czujko Stephen , Glascock Michael D. , Neff Hector , Renson Virginie 
Published: October 2024

AbstractThe emergence of Sardis as an urban centre in the early Iron Age coincided with local production of fine painted pottery in a distinctive regional idiom. Examples of Lydian-style pottery found across western Anatolia from the eighth century BC attest the city’s growing cultural and economic contacts as well as consistent materials and craft methods. Archaeo- metric study using neutron activation analysis (NAA) at the University of Missouri Research Reactor (MURR) examined representative specimens of Lydian-style ceramics from Sardis and compared their composition with later examples of red-gloss and red-slipped pottery, fine grey wares and transport jars commonly found at the site. The results confirm the sustained activity of local workshops from the early Iron Age into later historical periods, as Lydia became part of the Seleucid and Roman empires and Sardis a centre of regional innovation.
The Luwian word for ‘city, town’
Authors: Goedegebuure Petra M. 
Published: October 2024

AbstractThe Luwian corpus written in Anatolian hieroglyphs consists of about 300 inscriptions. Though this is sufficiently large that Luwian is mostly understood, not all words are known in full writing. One of those is the word for ‘city, town’. Since cities play an important role in Luwian monumental inscriptions, it is remarkable that the word for such a central concept is still unknown. Using a multi-modal approach, combing orthographic, morphological, iconographical and archaeological analysis, I argue that the word for ‘city’ is /allamminna/i-/ ‘fortified settlement > city tout court’, and that the hieroglyph for ‘city’ depicts a merlon, a raised section of a fortification’s battlement, thus linking it to the Hittite tower-vessels that express the relationship between city and fortifications in a material way. The identification of /allamminna/i-/ also impacts the analysis of other Hittite and Luwian words that are hitherto not well understood or not understood at all. Furthermore, it increases our understanding of aspects of the material world and of the cultural and linguistic interactions between Anatolian and Syrian societies. Finally, it illustrates the impact of Luwian and Luwians on Hittite society.
Enhancing Weather Forecast Accuracy Through the Integration of WRF and BP Neural Networks: A Novel Approach
Authors: Liu Zeyang , Zhang Jing , Yang Yadong , Wang Yaping , Luo Wangjun , Zhou Xiancun 
Published: October 2024

AbstractIn the past century, scholars from both domestic and international communities have delved into the study of numerical weather prediction models to promptly understand meteorological factors and mitigate the impacts of extreme weather events on humanity. Effective and precise prediction models enable the forecasting of meteorological conditions in the upcoming days, empowering individuals to implement proactive measures to minimize the adverse effects of extreme weather (Liang et al., 2021). The WRF (Weather Research and Forecasting) modeling system is commonly used for forecasting meteorological elements. However, uncertainties terribly hamper the correctness of the forecasting results. To this end, the present study was conducted to build a secondary model on the basis of the WRF forecast model. The WRF‐BPNN model was proposed for verification after constructing the network, the temperature vertical profile and the mixing ratio vertical profile were predicted, and the results on the validation set were tested. The results showed that the WRF‐BPNN model could effectively predict the temperature profile and mixing ratio profile, presenting better performance than the traditional WRF model.
Field Observations of Surfzone Vorticity
Authors: Dooley C. , Elgar Steve , Raubenheimer Britt 
Published: October 2024

AbstractIn the surfzone, breaking‐wave generated eddies and vortices transport material along the coast and offshore to the continental shelf, providing a pathway from land to the ocean. Here, surfzone vorticity is investigated with unique field observations obtained during a wide range of wave and bathymetric conditions on an Atlantic Ocean beach. Small spatial‐scale [O(10 m)] vorticity estimated with a 5 m diameter ring of 14 current meters deployed in ∼2 m water depth increased as the directional spread of the wave field increased. Large spatial‐scale [O(100 m)] vorticity calculated from remote sensing estimates of currents across the surfzone along 200 m of the shoreline increased as alongshore bathymetric variability (channels, bars, bumps, holes) increased. For all bathymetric conditions, large‐scale vorticity in the inner surfzone was more energetic than in the outer surfzone.
What Controls the Dawn‐Dusk Asymmetry of Dayside Alfvénic Power: Interplanetary Magnetic Field or Ionospheric Conductance?
Authors: Fu Shiqi , Zhang Binzheng , Lei Jiuhou , Lotko William , Yang Ziyi , Dang Tong , Luan Xiaoli 
Published: October 2024

AbstractAlfvén waves are important carriers of solar wind energy into the Earth's magnetosphere and upper atmosphere. The observed distribution of Alfvénic power at low altitude exhibits significant dawn‐dusk asymmetry with different causes and impacts on the dayside and nighside. The nightside asymmetry has been shown to be controlled by the meridional gradient in the ionospheric Hall conductance. It is not clear what controls the dayside asymmetry. Both the ionospheric conductance gradient and orientation of the y‐component of the interplanetary magnetic field (IMF) are possible factors. We examined both possibilities using global magnetohydrodynamic (MHD) simulations. Our results show: (a) The dayside distribution of Alfvénic power is very sensitive to the orientation of IMF By, with enhanced power in the dawn (dusk) sector of the northern hemisphere for positive (negative) By (and opposite in the southern hemisphere); and (b) gradients in ionospheric conductance exert a weaker influence on the dayside asymmetry.
Locating Boundaries Between Locked and Creeping Regions at Nankai and Cascadia Subduction Zones
Authors: Sherrill E. M. , Johnson K. M. , Jackson N. M. 
Published: October 2024

AbstractInterseismic coupling maps and, especially, estimates of the location of the fully coupled (locked) zone relative to the trench, coastline, and slow slip events are crucial for determining megathrust earthquake hazard at subduction zones. We present an interseismic coupling inversion that estimates the locations of the upper and lower boundaries of the locked zone, the lower boundary of the deep transition zone, and downdip gradient of creep rate in the transition from locked to freely creeping in the downdip transition zone. We show that the locked zone at Cascadia is west of the coastline and 10 km updip of the slow slip zone along much of the margin, widest (25–125 km, extending to ∼19 km depth) in northern Cascadia, narrowest (0–70 km) in central Cascadia, with moment accumulation rate equivalent to a Mw 8.71 and Mw 8.85 earthquake for 300‐ and 500‐year earthquake cycles. We find a steep gradient in creep immediately below the locked zone, indicative of propagating creep, along the entire margin. At Nankai, we find three distinct zones of locking (offshore Shikoku, offshore southeast Kii peninsula, and offshore Shima peninsula) with a total moment accumulation rate equivalent to a Mw 8.70 earthquake for a 150‐year earthquake cycle. The bottom of the locked zone is nearly under the coastline for all three locked regions at Nankai and is positioned 0–5 km updip of the slow slip zone. In contrast with Cascadia, creep rate gradients below the locked zone at Nankai are generally gradual, consistent with stationary locking.
Dynamic Thermomechanical Modeling of Rock‐Ice Avalanches: Understanding Flow Transitions, Water Dynamics, and Uncertainties
Authors: Munch Jessica , Zhuang Yu , Dash Rajesh Kumar , Bartelt Perry 
Published: October 2024

AbstractThe rapid melting of glaciers and thawing of permafrost in mountainous regions have heightened the danger of rock‐ice avalanches. These avalanches pose a severe threat due to their potential to transform into water‐saturated debris flows. The catastrophic event in Chamoli, India, on 7 February 2021, illustrates the devastating consequences of such processes. Developing a model capable of predicting the dynamics and extent of these events is imperative for natural hazard science and disaster mitigation. In response, we propose a depth‐averaged rock‐ice avalanche model encompassing four distinct materials: rock, ice, snow, and water. The model integrates crucial physical processes, including frictional heating, phase changes, ground material entrainment, and air‐blast hazards. Through a system of mass and momentum balance equations extended with grain flow and internal energy equations, the model captures heat exchanges and resulting phase changes as the fragmented material flows. Focusing on identifying the primary water source in the flow and testing the model on the 2021 Chamoli event, we quantify water's influence on flow dynamics and regime transitions. However, uncertainties persist in heat transfer physics and quantifying the hydro‐meteorological state of the flow path. Our thermo‐mechanical model enables the simulation of complex avalanches and identifies key flow transitions: powder cloud formation and potential debris flow transformation. The study underscores the pivotal role of water in avalanche dynamics and the challenge of accurately quantifying water content within the flow, necessitating comprehensive ground assessments for effective disaster management.
Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive Rhabdomyosarcoma
Authors: Hsieh Joseph , Danis Etienne P. , Owens Charles R. , Parrish Janet K. , Nowling Nathan L. , Wolin Arthur R. , Purdy Stephen Connor , Rosenbaum Sheera R. , Ivancevic Atma M. , Chuong Edward B. , Ford Heide L. , Jedlicka Paul 
Published: October 2024

AbstractRhabdomyosarcoma (RMS), a malignancy of impaired myogenic differentiation, is the most common soft tissue pediatric cancer. PAX3-FOXO1 oncofusions drive the majority of the clinically more aggressive fusion-positive rhabdomyosarcoma (FP-RMS). Recent studies have established an epigenetic basis for PAX3-FOXO1-driven oncogenic processes. However, details of PAX3-FOXO1 epigenetic mechanisms, including interactions with, and dependence on, other chromatin and transcription factors, are incompletely understood. We previously identified a novel disease-promoting epigenetic axis in RMS, involving the histone demethylase KDM3A and the ETS1 transcription factor, and demonstrated that this epigenetic axis interfaces with PAX3-FOXO1 both phenotypically and transcriptomically, including co-regulation of biological processes and genes important to FP-RMS progression. In this study, we demonstrate that KDM3A and ETS1 colocalize with PAX3-FOXO1 to enhancers of important disease-promoting genes in FP-RMS, including FGF8, IL4R, and MEST, as well as PODXL, which we define herein as a new FP-RMS-promoting gene. We show that ETS1, which is induced by both PAX3-FOXO1 and KDM3A, exists in complex with PAX3-FOXO1, and augments PAX3-FOXO1 chromatin occupancy. We further show that the PAX3-FOXO1/ETS1 complex can be disrupted by the clinically relevant small molecule inhibitor YK-4-279. YK-4-279 displaces PAX3-FOXO1 from chromatin and interferes with PAX3-FOXO1-dependent gene regulation, resulting in potent inhibition of growth and invasive properties in FP-RMS, along with downregulation of FGF8, IL4R, MEST and PODXL expression. We additionally show that, in some FP-RMS, KDM3A also increases PAX3-FOXO1 levels. Together, our studies illuminate mechanisms of action of the KDM3A/ETS1 regulatory module, and reveal novel targetable mechanisms of PAX3-FOXO1 chromatin complex regulation, in FP-RMS.
Intravenous chaperone treatment of late-stage Alzheimer´s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes
Authors: Zhang Ruixin , Ohshima Makiko , Brodin David , Wang Yu , Morancé Antonin , Schultzberg Marianne , Chen Gefei , Johansson Jan 
Published: October 2024

AbstractTreatment strategies that are efficient against established Alzheimer’s disease (AD) are needed. BRICHOS is a molecular chaperone domain that prevents amyloid fibril formation and associated cellular toxicity. In this study, we treated an AD mouse model seven months after pathology onset, using intravenous administration of recombinant human (rh) Bri2 BRICHOS R221E. Two injections of rh Bri2 BRICHOS R221E per week for three months in AD mice reduced amyloid β (Aβ) burden, and mitigated astro- and microgliosis, as determined by glial fibrillary acidic protein (GFAP) and ionized calcium-binding adaptor molecule 1 (Iba1) immunohistochemistry. Sequencing of RNA from cortical microglia cells showed that BRICHOS treatment normalized the expression of identified plaque-induced genes in mice and humans, including clusterin and GFAP. Rh Bri2 BRICHOS R221E passed the blood–brain barrier (BBB) in age-matched wild-type mice as efficiently as in the AD mice, but then had no effect on measures of AD-like pathology, and mainly affected the expression of genes that affect cellular shape and movement. These results indicate a potential of rh Bri2 BRICHOS against advanced AD and underscore the ability of BRICHOS to target amyloid-induced pathology.
Distribution and associated factors of choroidal thickness in highly myopic eyes—a real-world study based on a Chinese population
Authors: Shao Lei , Zhao HanQing , Zhang RuiHeng , Zhou WenDa , Wei Wen Bin 
Published: October 2024

Abstract

Purpose
To measure the subfoveal choroidal thickness (SFCT) in highly myopic eyes at different locations using enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). To identify the ocular and systemic risk factors associated with choroidal thinning in high myopia.

Methods
Based on the Beijing Eye Study, a detailed ophthalmic examination was performed including EDI SD-OCT for the measurement of SFCT. OCT images were obtained from 103 highly myopic eyes (≥ −6.00 dioptres) and 227 normal eyes randomly selected from the baseline population, matched for age and sex.

Results
The mean SFCT was 110.6 ± 85.2 μm in highly myopic eyes (range, 3–395 μm). Mean regional choroidal thickness was lowest on the nasal and inferior sides of the macula, and slightly higher on the temporal and superior sides than at the fovea. On multivariate analysis, SFCT was associated with age (b = −0.48; P < 0.001), axial length (b = −0.44; P < 0.001), gender (b = −0.31; P < 0.05) and staphyloma (b = −0.26; P = 0.05). In highly myopic eyes, SFCT decreased by 5.1 μm/year of age, by 9.2 µm/D of myopia, and by 22.6 µm/mm of axial length.

Conclusions
The SFCT decreases with age and increased axial length in highly myopic eyes. The formation of a posterior staphyloma has been identified as a major contributor to choroidal thinning and is therefore a reliable indicator for risk management. The involvement of choroidal abnormalities may be a significant factor in the development of myopic degeneration.
Structure, interaction and nervous connectivity of beta cell primary cilia
Authors: Müller Andreas , Klena Nikolai , Pang Song , Garcia Leticia Elizabeth Galicia , Topcheva Oleksandra , Aurrecoechea Duran Solange , Sulaymankhil Davud , Seliskar Monika , Mziaut Hassan , Schöniger Eyke , Friedland Daniela , Kipke Nicole , Kretschmar Susanne , Münster Carla , Weitz Jürgen , Distler Marius , Kurth Thomas , Schmidt Deborah , Hess Harald F. , Xu C. Shan , Pigino Gaia , Solimena Michele 
Published: October 2024

AbstractPrimary cilia are sensory organelles present in many cell types, partaking in various signaling processes. Primary cilia of pancreatic beta cells play pivotal roles in paracrine signaling and their dysfunction is linked to diabetes. Yet, the structural basis for their functions is unclear. We present three-dimensional reconstructions of beta cell primary cilia by electron and expansion microscopy. These cilia are spatially confined within deep ciliary pockets or narrow spaces between cells, lack motility components and display an unstructured axoneme organization. Furthermore, we observe a plethora of beta cell cilia-cilia and cilia-cell interactions with other islet and non-islet cells. Most remarkably, we have identified and characterized axo-ciliary synapses between beta cell cilia and the cholinergic islet innervation. These findings highlight the beta cell cilia’s role in islet connectivity, pointing at their function in integrating islet intrinsic and extrinsic signals and contribute to understanding their significance in health and diabetes.
Subclassification of obesity for precision prediction of cardiometabolic diseases
Authors: Coral Daniel E. , Smit Femke , Farzaneh Ali , Gieswinkel Alexander , Tajes Juan Fernandez , Sparsø Thomas , Delfin Carl , Bauvin Pierre , Wang Kan , Temprosa Marinella , De Cock Diederik , Blanch Jordi , Fernández-Real José Manuel , Ramos Rafael , Ikram M. Kamran , Gomez Maria F. , Kavousi Maryam , Panova-Noeva Marina , Wild Philipp S. , van der Kallen Carla , Adriaens Michiel , van Greevenbroek Marleen , Arts Ilja , Le Roux Carel , Ahmadizar Fariba , Frayling Timothy M. , Giordano Giuseppe N. , Pearson Ewan R. , Franks Paul W. 
Published: October 2024

Abstract
Obesity and cardiometabolic disease often, but not always, coincide. Distinguishing subpopulations within which cardiometabolic risk diverges from the risk expected for a given body mass index (BMI) may facilitate precision prevention of cardiometabolic diseases. Accordingly, we performed unsupervised clustering in four European population-based cohorts (N ≈ 173,000). We detected five discordant profiles consisting of individuals with cardiometabolic biomarkers higher or lower than expected given their BMI, which generally increases disease risk, in total representing ~20% of the total population. Persons with discordant profiles differed from concordant individuals in prevalence and future risk of major adverse cardiovascular events (MACE) and type 2 diabetes. Subtle BMI-discordances in biomarkers affected disease risk. For instance, a 10% higher probability of having a discordant lipid profile was associated with a 5% higher risk of MACE (hazard ratio in women 1.05, 95% confidence interval 1.03, 1.06, P = 4.19 × 10−10; hazard ratio in men 1.05, 95% confidence interval 1.04, 1.06, P = 9.33 × 10−14). Multivariate prediction models for MACE and type 2 diabetes performed better when incorporating discordant profile information (likelihood ratio test P < 0.001). This enhancement represents an additional net benefit of 4−15 additional correct interventions and 37−135 additional unnecessary interventions correctly avoided for every 10,000 individuals tested.
Oxidative stress, histopathological and genotoxicity of copper oxide nanoparticles in Biomphalaria alexandrina snail
Authors: Fol Mona Fathi , Abdel-Ghaffar Fathi A. , Hassan Hassan Abdel-Malek , Ibrahim Amina Mohamed 
Published: October 2024

AbstractHigher usage of copper oxide nanomaterials in industrial and biomedical fields may cause an increase of these nanoparticles in aquatic environments, which could have a detrimental ecological effect. Thus, the objective of this study was to evaluate the acute toxicity of copper oxide nanoparticles on the freshwater gastropod, Biomphalaria alexandrina. Transmission electron microscopy, x-ray diffraction analysis and UV–VIS spectrophotometer of CuO NPs revealed a typical TEM image and a single crystal structure with average crystallite size of approximately 40 nm also, a sharp absorption band was appeared. Following exposure to sub-lethal concentrations of CuO NPs (LC10, 15.6 mg/l and LC25, 27.2 mg/l), treated snails revealed a significant decrease (p < 0.05) in total antioxidant capacity, reduced glutathione contents as well as catalase, and sodium dismutase activities were significantly declined (p < 0.05) in comparison to the control group. Also, histopathological alterations were observed in the digestive gland, including ruptured and vacuolated digestive cells, and a marked increase in the number of secretory cells and the severity of the damage increased with rising concentrations. Furthermore, changes in RAPD profiles were detected in the treated snails. In conclusion, our research highlights the potential ecological impact of CuO NPs release in aquatic ecosystems and advocates for improved monitoring and regulation of CuO NPs industrial usage and disposal.
Injured inflammatory environment overrides the TET2 shaped epigenetic landscape of pluripotent stem cell derived human neural stem cells
Authors: Kamei Noriko , Day Kenneth , Guo Wei , Haus Daniel L. , Nguyen Hal X. , Scarfone Vanessa M. , Booher Keith , Jia Xi-Yu , Cummings Brian J. , Anderson Aileen J. 
Published: October 2024

AbstractSpinal cord injury creates an inflammatory microenvironment that regulates the capacity of transplanted human Neural Stem Cells (hNSC) to migrate, differentiate, and repair injury. Despite similarities in gene expression and markers detected by immunostaining, hNSC populations exhibit heterogeneous therapeutic potential. This heterogeneity derives in part from the epigenetic landscape in the hNSC genome, specifically methylation (5mC) and hydroxymethylation (5hmC) state, which may affect the response of transplanted hNSC in the injury microenvironment and thereby modulate repair capacity. We demonstrate a significant up-regulation of methylcytosine dioxygenase 2 gene (TET2) expression in undifferentiated hNSC derived from human embryonic stem cells (hES-NSC), and report that this is associated with hES-NSC competence for differentiation marker expression. TET2 protein catalyzes active demethylation and TET2 upregulation could be a signature of pluripotent exit, while shaping the epigenetic landscape in hES-NSC. We determine that the inflammatory environment overrides epigenetic programming in vitro and in vivo by directly modulating TET2 expression levels in hES-NSC to change cell fate. We also report the effect of cell fate and microenvironment on differential methylation 5mC/5hmC balance. Understanding how the activity of epigenetic modifiers changes within the transplantation niche in vivo is crucial for assessment of hES-NSC behavior for potential clinical applications.