bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Independent Expert Reports in Australian M&A Market
Authors: Nguyen Giang Duc 
Published: July 2017

AbstractThis paper examines the role of independent expert reports in Australian M&A market. Using a comprehensive sample of 2888 transactions between 1991 and 2013, I find that a “neither fair nor reasonable” opinion forces the acquirer to increase the offer premium by 5%, ceteris paribus. The finding remains robust after controlling for the target's bargaining power measured by the residual values of initial premiums that are not explained by observable firm‐deal characteristics. The target that has a weak bargaining position tends to receive less effect of an unfavorable report. In addition, a “fair and reasonable” opinion increases the probability of success, while the unfavorable report does not affect the transaction outcome. I identify the causal effect of expert opinions by differences‐in‐differences analysis using the Duke case decision.
Comparison of long‐term safety of fixed‐dose combinations azilsartan medoxomil/chlorthalidone vs olmesartan medoxomil/hydrochlorothiazide
Authors: Neutel Joel M. , Cushman William C. , Lloyd Eric , Barger Bruce , Handley Alison 
Published: July 2017

This 52‐week, randomized, open‐label study evaluated long‐term safety/tolerability of fixed‐dose combination azilsartan medoxomil/chlorthalidone (AZL‐M/CLD) vs fixed‐dose combination olmesartan medoxomil/hydrochlorothiazide (OLM/HCTZ) in patients with essential hypertension (stage 2; clinic systolic blood pressure 160–190 mm Hg). Initial AZL‐M/CLD 40/12.5 mg/d (n=418) or OLM/HCTZ 20/12.5 mg/d (n=419) could be uptitrated during weeks 4 to 52 (AZL‐M/CLD to 80/25 mg; OLM/HCTZ to 40/25 mg [United States] or 20/25 mg [Europe]) to meet blood pressure targets. Treatment‐emergent adverse events/serious adverse events occurred in 78.5%/5.7% of patients taking AZL‐M/CLD vs 76.4%/6.2% taking OLM/HCTZ. The most frequent adverse events were dizziness (16.3% vs 12.6%), blood creatinine increase (21.5% vs 8.6%), headache (7.4% vs 11.0%), and nasopharyngitis (12.2% vs 11.5%). Hypokalemia was uncommon (1.0% vs 0.7%). Greater blood pressure reductions with AZL‐M/CLD by week 2 were maintained throughout the study, despite less uptitration (32.3% vs 48.9% with OLM/HCTZ). Fixed‐dose combination AZL‐M/CLD showed an encouraging benefit‐risk profile when used per standard clinical practice in a titrate‐to‐target strategy.
Infantile hemangiomas with minimal or arrested growth associated with soft tissue hypertrophy: a case series of 10 patients
Authors: Planas‐Ciudad S. , Roé Crespo E. , Sánchez‐Carpintero I. , Frieden I.J. , Martín‐Santiago A. , Redondo Bellón P. , Moreno Artero E. , Osier E. , Puig Sanz L. , Baselga Torres E. 
Published: July 2017

AbstractBackgroundInfantile hemangiomas with minimal or arrested growth (IH‐MAGs) are characterized by a proliferative component of <25% of its surface area. The co‐occurrence of IH‐MAGs and soft tissue anomalies is rare, and case series of this association are lacking.ObjectiveWe present 10 cases of IH‐MAGs associated with soft tissue hypertrophy and describe their clinical features.MethodsWe reviewed all infantile hemangiomas with minimal or arrested growth seen between 2009 and 2016 in the dermatology clinic department at Hospital Santa Creu i Sant Pau, Barcelona. To collect more patients, we also requested cases from the Hemangioma Investigator Group and members of the Spanish Society of Vascular Anomalies.ResultsTen patients had IH‐MAGs associated with soft tissue hypertrophy; seven involving the arm and three involving the leg. All displayed a segmental pattern, a doughy and puffy texture and prominent surface veins. No significant asymmetries in limbs and no other visceral anomalies were observed at follow‐up (range 15 months to 7 years). One patient reported coldness in the limb with infantile hemangioma, but RMI‐angiography did not disclose a vascular malformation underneath the lesion. Ulceration was observed in three patients. The proliferative component in all IH‐MAGs had faded at 1‐year follow‐up, while soft tissue hypertrophy and prominent vessels remained unchanged.ConclusionsIn this first case series of IH‐MAGS associated with soft tissue hypertrophy, soft tissue hypertrophy was not progressive and remained unchanged over time, unlike the proliferative component of classic infantile hemangioma. The origin of the prominent vessels and the higher ulceration risk are unknown; however, these findings are probably related to a minor disruption of local vessels not detected in imaging tests.
Tumescent local anaesthesia for early dermatosurgery in infants
Authors: Heister M. , Häfner H.M. , Breuninger H. , Schulz C. , Meier K. , Kofler L. , Spott C. , Röcken M. , Schnabl S.M. , Eberle F.C. 
Published: July 2017

AbstractBackgroundEarly paediatric dermatosurgery reveals excellent cosmetic results due to high skin elasticity and pronounced capacity to recover from trauma. Furthermore, the size of skin lesions increases during life proportionally to skin growth and therefore early removal is of major importance. Selected local anaesthetics like prilocaine can cause methaemoglobinemia. However, in contrast to general anaesthesia, many other local anaesthetics do not bare any major risks for infants.ObjectiveIn this retrospective study, we analysed infants aged less than 7 months receiving tumescent local anaesthesia (TLA) followed by dermatosurgery at our department between 2005 and 2015. The analysis is mainly based on our records. Additional information for a subset of patients was gained by a postoperative survey.MethodsNinety‐two infants (39 male, 53 female) with a median age of 4.2 months (range: 1.5 months; 6.7 months) were included in this study. Additional postoperative information was available for 33 of the 92 studied patients (35%).ResultsInfants were mainly operated for removal of a melanocytic naevus (n = 54), followed by haemangioma (n = 23), naevus sebaceous (n = 6) and other lesions (n = 9). The lesions were located on the scalp or neck (n = 31), on the extremities (n = 31), on the trunk (n = 21), in the face (n = 6) or on the buttocks (n = 3). The median size of excision was 509 mm2 (range: 16 mm2; 3600 mm2). Primary defect closure was performed by intracutaneous (n = 68) or extracutaneous (n = 24) suture techniques. No side‐effects of local anaesthesia were observed in any patient. Postoperative complications include pain (1/33; 3%), wound‐healing disorder (1/33; 3%) and visible severe scarring (2/33; 6%).ConclusionsThe combination of TLA and dermatosurgery in infants is a suitable outpatient treatment option for small lesions without any major risks or side‐effects and the benefit of prolonged postoperative analgesia.
Systematic development of esthetics and function in a young patient with maxillary dental aplasia
Authors: Edelhoff D. , Prandtner O. , Saeidi Pour R. , Wichelhaus A. , Liebermann A. 
Published: July 2017

ABSTRACTObjectivesFull‐arch rehabilitations in young patients suffering from dental agenesis should compensate for the reduced vertical dimension of occlusion and restore both esthetics and function at minimal biological cost. This requires precise planning and maximum patient compliance during the preprosthetic phase. The pretreatment period with tooth‐colored splints promotes a predictable outcome of the final restorations.Clinical considerations: Thanks to better restorative materials and adhesive techniques and increased knowledge of how to preserve sound tooth structures, prosthetic dentistry has increasingly turned toward minimally invasive procedures. The present clinical case documents a minimally/non‐invasive maxillary full‐arch rehabilitation of an agenesis patient with multiple dental aplasia, primary tooth persistence, and deficits in bone growth. The patient was pretreated with a tooth‐colored CAD/CAM polycarbonate splint. Adequate esthetics and function were achieved by two zirconia‐based single‐wing adhesive fixed dental prostheses to replace the upper lateral incisors, lithium disilicate ceramic partial crowns for the posterior regions, and two feldspathic veneers for the upper central incisors.ConclusionsNon‐invasive pretreatment with a removable tooth‐colored splint realizes the treatment goal simply and safely, reduces treatment time, increases predictability, and facilitates the transfer of the prototype to the final restorations. New restorative options permit the minimally invasive treatment of such patients.CLINICAL SIGNIFICANCEA pretreatment with a removable tooth‐colored splint offers a simple and safe way to define the treatment goal, reduces treatment time, increases predictability, and facilitates the transfer of the results to the final restorations even in complex cases. New restorative options permit minimally invasive treatments of young patients with multiple dental agenesis.
Noradrenergic modulation of gonadotrophin‐inhibitory hormone gene expression in the brain of Japanese quail
Authors: Tobari Y. , Kansaku N. , Tsutsui K. 
Published: July 2017

Gonadotrophin‐inhibitory hormone (GnIH) is a hypothalamic neuropeptide that inhibits gonadotrophin synthesis and release in birds and mammals. In Japanese quail, GnIH neurones express the noradrenergic receptor and receive noradrenergic innervation. Treatment with noradrenaline (NA) stimulates GnIH release from diencephalic tissue blocks in vitro. However, the effects of NA on hypothalamic GnIH gene expression have not been determined. We investigated noradrenergic regulation of GnIH gene expression in the brain of male quail using the selective noradrenergic neurotoxin N‐(2‐chloroethyl)‐N‐ethyl‐2‐bromobenzylamine hydrochloride (DSP‐4). We first showed that DSP‐4 reduced the number of noradrenergic (dopamine‐β‐hydroxylase immunoreactive) cells in the locus coeruleus (LoC) and specifically lowered the NA concentration in the hypothalamus of male quail. Other monoamines, such as dopamine and serotonin, were not affected by drug treatment. DSP‐4 did not decrease the numbers of noradrenergic cells of the lateral tegmental cell group, nor the plasma NA concentration. Decreased hypothalamic NA levels after DSP‐4 treatment did not change GnIH gene expression in the brains of quail during their interaction with conspecifics. On the other hand, GnIH gene expression increased in the brains of quail socially isolated for 1 hour after DSP‐4 treatment. These results suggest that some noradrenergic neurones have inhibitory effects on GnIH gene expression of the hypothalamus in solitary quail.
Direct and tunable modulation of protein levels in rice and wheat with a synthetic small molecule
Authors: Zhang Jingbo , Yin Kangquan , Sun Juan , Gao Jinlan , Du Qiuli , Li Huali , Qiu Jin‐Long 
Published: July 2017

SummaryDirect control of protein level enables rapid and efficient analyses of gene functions in crops. Previously, we developed the RDDK‐Shield1 (Shld1) system in the model plant Arabidopsis thaliana for direct modulation of protein stabilization using a synthetic small molecule. However, it was unclear whether this system is applicable to economically important crops. In this study, we show that the RDDK‐Shld1 system enables rapid and tunable control of protein levels in rice and wheat. Accumulation of RDDK fusion proteins can be reversibly and spatio‐temporally controlled by the synthetic small‐molecule Shld1. Moreover, RDDK‐Bar and RDDK‐Pid3 fusions confer herbicide and rice blast resistance, respectively, in a Shld1‐dependent manner. Therefore, the RDDK‐Shld1 system provides a reversible and tunable technique for controlling protein functions and conditional expression of transgenes in crops.
Theistic Modal Realism II: Theoretical Benefits
Authors: Almeida Michael 
Published: July 2017

AbstractIn Sections 1–7, I provide a detailed description of some of the advantages of theistic modal realism. The aim is to show specifically how theistic modal realism solves many of the intractable problems of philosophical theology. A detailed description of all of the advantages would require a much longer treatment. The aim is to give a good sense of the theoretical benefits that theistic modal realism affords traditional theists. I offer some concluding remarks in Section 8.
Fluid Inclusions and Hydrogen, Oxygen, and Lead Isotopes of the Antuoling Molybdenum Deposit, Northern Taihang Mountains, China
Authors: Zhe Meng , Hu Jian‐zhong , Song Yang , Zhang Xue‐qin , Ding Hai‐yang , Zhou Wei 
Published: July 2017

AbstractThe Antuoling Mo deposit is a major porphyry‐type deposit in the polymetallic metallogenic belt of the northern Taihang Mountains, China. The processes of mineralization in this deposit can be divided into three stages: an early quartz–pyrite stage, a middle quartz–polymetallic sulfide stage, and a late quartz–carbonate stage. Four types of primary fluid inclusions are found in the deposit: two‐phase aqueous inclusions, daughter‐mineral‐bearing multiphase inclusions, CO2–H2O inclusions, and pure CO2 inclusions. From the early to the late ore‐forming stages, the homogenization temperatures of the fluid inclusions are 300 to >500°C, 270–425°C, and 195–330°C, respectively, with salinities of up to 50.2 wt%, 5.3–47.3 wt%, and 2.2–10.4 wt% NaCl equivalent, revealing that the ore‐forming fluids changed from high temperature and high salinity to lower temperature and lower salinity. Moreover, based on the laser Raman spectra, the compositions of the fluid inclusions evolved from the NaCl–CO2–H2O to the NaCl–H2O system. The δ18OH2O and δD values of quartz in the deposit range from +3.9‰ to +7.0‰ and −117.5‰ to −134.2‰, respectively, reflecting the δD of local meteoric water after oxygen isotopic exchange with host rocks. The Pb isotope values of the sulfides (208Pb/204Pb, 36.320–37.428; 207Pb/204Pb, 15.210–15.495; 206Pb/204Pb, 16.366–17.822) indicate that the ore‐forming materials originated from a mixed upper mantle–lower crust source.
Crafting Mass Dairy Production: Immigration and Community in Rural America
Authors: Garni Alisa 
Published: July 2017

AbstractIn many parts of rural America, agrofood producers compete for a larger share of global markets by mechanizing, deskilling, and flexibly relocating to reduce labor costs. They recruit new immigrant workers but sow transience rather than sustainable rural growth. The industrialization of U.S. dairy farming appears to be aligned with these processes, and yet the large‐scale dairy farmers who have replaced small craft producers face a paradox: The more they rationalize production on their farms, the more vulnerable their herds become to stress and illness, compromising production. Focusing on three competing dairies in Kansas, I examine how farmers variously organize work among immigrant employees to promote herd health while expanding their operations. Evidence from 22 months of ethnographic research and repeated interviews with farm owners, managers, employees, and extension agents suggests that enhancing production requires promoting employee citizenship at work—especially among immigrant employees possessing the fewest citizenship rights outside of work. In contrast to the high labor turnover endemic to other forms of industrialized food production, the distinctive human‐animal relations central to dairying encourage farm owners and employees to cooperate, with promising results for farms and rural communities.
Impact of drugs on intradialytic hypotension: Antihypertensives and vasoconstrictors
Authors: Chang Tara I. 
Published: July 2017

AbstractIntradialytic hypotension (IDH) is a common complication of hemodialysis and is associated with numerous adverse outcomes including cardiovascular events, inadequate dialysis, loss of vascular access, and death. It is estimated that approximately 20%‐30% of all dialysis sessions are affected by IDH. In seeking ways to reduce the occurrence of IDH, dialysis providers often turn to pharmacological approaches: withholding antihypertensive medications prior to hemodialysis or administering vasoconstrictor medications. This review will focus on what is known about the relation between antihypertensive medications and IDH, and summarize studies that have examined the efficacy of vasoconstrictor medications on IDH, including midodrine, arginine vasopressin, and droxidopa. However, there is currently scant evidence that any pharmacological approach is particularly effective in reducing IDH. Additional studies of potential treatments for IDH are needed, and should examine not only hemodynamic effects such as changes in nadir blood pressure during dialysis, but also on patient‐centered and clinical outcomes such as symptoms of IDH, quality of life, and cardiovascular events.
Magnetic resonance imaging appearance of the brain and cervical spinal cord in an edema disease affected pig
Authors: Dieste‐Pérez Lucía , Dobak Tetyda P. , Vilaplana Grosso Federico R. , Bergmann Wilhelmina , Tobias Tijs J. 
Published: July 2017

AbstractA 7‐week‐old male pig was presented with signs of a central nervous system disorder. An MRI of the head and cervical spine was performed immediately after euthanasia. The MRI revealed multifocal bilaterally symmetric T2‐weighted hyperintense lesions in the brain and spinal cord, likely due to a toxic metabolic process. Histopathological examination supported the MRI findings and confirmed the diagnosis of edema disease due to Shiga‐like toxin produced by Escherichia coli. This is the first case published of the MRI findings in an edema disease affected pig.
Does Physical Activity Mediate the Association Between Perceived Neighborhood Aesthetics and Overweight/Obesity Among South African Adults Living in Selected Urban and Rural Communities?
Authors: Malambo Pasmore , Kengne Andre P. , Lambert Estelle V. , De Villiers Anniza , Puoane Thandi 
Published: July 2017

Background: To investigate the mediation effects of physical activity (PA) on the relationship between the perceived neighborhood aesthetic environment and overweight/obesity in free-living South Africans. Methods: A cross-sectional study of 671 adults aged ≥ 35 years was analyzed. PA was assessed using the validated International Physical Activity Questionnaire. Perceived neighborhood aesthetics was assessed using the Neighborhood Environment Walkability Scale Questionnaire. Results: Of 671 participants, 76.0% were women, 34.1% aged 45–54 years, and 69.2% were overweight or obese. In adjusted logistic regression models, overweight/obesity was significantly associated with neighborhood aesthetics [odds ratio (OR) = 0.68; 95% confidence interval (CI), 0.50–0.93] and PA (OR = 0.65; 95% CI, 0.65–0.90). In expanded multivariable models, overweight/obesity was associated with age 45–55 years (OR = 1.59; 95% CI, 1.05–2.40), female gender (OR = 6.24; 95% CI, 3.95–9.86), tertiary education (OR = 4.05; 95% CI, 1.19–13.86), and urban residence (OR = 2.46; 95% CI, 1.66–3.65). Conclusion: Aesthetics was positively associated with PA; both aesthetics and PA were negatively associated with overweight and obesity. There was no evidence to support a significant mediating effect of PA on the relationship between aesthetics and overweight/obesity. Future studies should consider objective assessment of aesthetics and PA. In addition, future studies should consider using longitudinal design to evaluate food-related environments, which are related to overweight or obesity.
How Is the Practice of Yoga Related to Weight Status? Population-Based Findings From Project EAT-IV
Authors: Neumark-Sztainer Dianne , MacLehose Richard F. , Watts Allison W. , Eisenberg Marla E. , Laska Melissa N. , Larson Nicole 
Published: July 2017

Background: Yoga may provide a strategy for healthy weight management in young adults. This study examined prevalence and characteristics of young adults’ yoga practice and associations with changes in body mass index. Methods: Surveys were completed by 1830 young adults (31.1 ± 1.6 y) participating in Project EAT-IV. Cross-sectional and 5-year longitudinal analyses were conducted stratified by initial weight status. Results: Two-thirds (66.5%) of nonoverweight women and 48.9% of overweight women reported ever doing yoga, while 27.2% of nonoverweight women and 16.4% of overweight women practiced regularly (≥30 min/wk). Fewer men practiced yoga. Among young adults practicing regularly (n = 294), differences were identified in intensity, type, and location of yoga practice across weight status. Young adults who were overweight and practiced yoga regularly showed a nonsignificant 5-year decrease in their body mass index (−0.60 kg/m2; P = .49), whereas those not practicing regularly had significant increases in their body mass index (+1.37 kg/m2; P < .01). Frequency of yoga was inversely associated with weight gain among both overweight and nonoverweight young adults practicing yoga regularly. Conclusions: Young adults of different body sizes practice yoga. Yoga was associated with less weight gain over time, particularly in overweight young adults. Practicing yoga on a regular basis may help with weight gain prevention.
Indoor and Outdoor Context-Specific Contributions to Early Adolescent Moderate to Vigorous Physical Activity as Measured by Combined Diary, Accelerometer, and GPS
Authors: Pearce Matthew , Saunders David H. , Allison Peter , Turner Anthony P. 
Published: July 2017

Background: The distribution of adolescent moderate to vigorous physical activity (MVPA) across multiple contexts is unclear. This study examined indoor and outdoor leisure time in terms of being structured or unstructured and explored relationships with total daily MVPA. Methods: Between September 2012 and January 2014, 70 participants (aged 11–13 y) from 4 schools in Edinburgh wore an accelerometer and global positioning system receiver over 7 days, reporting structured physical activity using a diary. Time spent and MVPA were summarized according to indoor/outdoor location and whether activity was structured/unstructured. Independent associations between context-specific time spent and total daily MVPA were examined using a multivariate linear regression model. Results: Very little time or MVPA was recorded in structured contexts. Unstructured outdoor leisure time was associated with an increase in total daily MVPA almost twice that of unstructured indoor leisure time [b value (95% confidence interval), 8.45 (1.71 to 14.48) vs 4.38 (0.20 to 8.22) minute increase per hour spent]. The association was stronger for time spent in structured outdoor leisure time [35.81 (20.60 to 52.27)]. Conclusions: Research and interventions should focus on strategies to facilitate time outdoors during unstructured leisure time and maximize MVPA once youth are outdoors. Increasing the proportion of youth engaging in structured activity may be beneficial given that, although time spent was limited, association with MVPA was strongest.