bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of preoperative anemia on outcomes in patients undergoing curative resection for gastric cancer: a single‐institution retrospective analysis of 2163 Chinese patients
Authors: Liu Xuechao , Qiu Haibo , Huang Yuying , Xu Dazhi , Li Wei , Li Yuanfang , Chen Yingbo , Zhou Zhiwei , Sun Xiaowei 
Published: January 2018

AbstractWe sought to evaluate whether preoperative anemia was an important determinant of survival in gastric cancer (GC). A single institution cohort of 2163 GC patients who underwent curative resection were retrospectively analyzed. Anemia was defined as a preoperative hemoglobin level <120 g/L in males and <110 g/L in females. Overall survival (OS) was analyzed using the Kaplan–Meier method, and a multivariate Cox proportional hazards model was performed to identify the independent prognostic factor. Anemic patients had a poorer OS compared with nonanemic patients after resection for tumor–nodes–metastasis (TNM) stage III tumors (5‐year OS rate: 32.2% vs. 45.7%, P < 0.001) but not stage I (P  =  0.480) or stage II (P  =  0.917) tumors. Multivariate analysis revealed that preoperative anemia was an independent prognostic factor in TNM stage III (hazard ratio [HR], 1.771; 95% CI, 1.040–3.015; P = 0.035). In a stage‐stratified analysis, preoperative anemia was still independently associated with OS in TNM stages IIIa through IIIc (P < 0.001, P = 0.075, and P = 0.012, respectively), though the association was only marginal in stage IIIb. Of note, preoperative mild anemia had a similar prognostic value in TNM stage III GC. Furthermore, preoperative anemia was significantly associated with more perioperative transfusions, postoperative complications and several nutritional‐based indices, including the prognostic nutritional index (PNI), preoperative weight loss and performance status (all P < 0.05). Preoperative anemia, even mild anemia, was an important predictor of postoperative survival for TNM stage III GC.
Clinical presentation and imaging of a rare case of Tarsal Tuberculosis
Authors: Kapetanakis Stylianos , Chourmouzi Danai , Papadopoulou Elissavet , Oikonomou Dimitrios , Gkantsinikoudis Nikolaos 
Published: January 2018

Key Clinical MessageA 43‐year‐old woman arrived to emergency unit of our hospital, referring intense deteriorated pain and swelling of midfoot. Rapid clinical evolvement of osteoarticular tuberculosis represents a potential clinical scenario. Clinicians should always include foot tuberculosis in differential diagnosis, in cases of severe clinical and radiological manifestations.
Chemical and Enzymatic Strategies for Bacterial and Mammalian Cell Surface Engineering
Authors: Bi Xiaobao , Yin Juan , Chen Guanbang Ashley , Liu Chuan‐Fa 
Published: January 2018

AbstractThe cell surface serves important functions such as the regulation of cell‐cell and cell‐environment interactions. The understanding and manipulation of the cell surface is important for a wide range of fundamental studies of cellular behavior and for biotechnological and medical applications. With the rapid advance of biology, chemistry and materials science, many strategies have been developed for the functionalization of bacterial and mammalian cell surfaces. Here, we review the recent development of chemical and enzymatic approaches to cell surface engineering with particular emphasis on discussing the advantages and limitations of each of these strategies.
Fluorescence Redox Blinking Adaptable to Structural Analysis of Nucleic Acids
Authors: Miyata Takafumi , Shimada Naohiko , Maruyama Atsushi , Kawai Kiyohiko 
Published: January 2018

AbstractThe phenomenon of blinking is unique to single‐molecule fluorescence measurements. By designing a fluorophore with an appropriate dark‐state lifetime τoff, a kinetic analysis based on the control of fluorescence blinking (KACB) was devised to investigate the dynamics of biomolecules. By controlling the redox‐reaction‐based blinking (rKACB), conformational dynamics of RNA at the single‐molecule level was previously investigated. However, there is little knowledge about suitable fluorescent molecules for rKACB, and the application of rKACB has been limited to the analysis of hairpins and duplex structures of nucleic acids. In this work, various fluorescent molecules, including Alexa 488, R6G, TAMRA, ATTO 647N and ATTO 655, were evaluated for rKACB. Moreover, rKACB was adapted to the discrimination of DNA/DNA and DNA/RNA nucleic acid duplexes and investigation of antigen–antibody interactions. By changing the size of the oxidant, it was possible to determine the solvent accessibility of the target domain of the analyzed biomolecules.
Enantioselective Synthesis of Aminodiols by Sequential Rhodium‐Catalysed Oxyamination/Kinetic Resolution: Expanding the Substrate Scope of Amidine‐Based Catalysis
Authors: Guasch Joan , Giménez‐Nueno Irene , Funes‐Ardoiz Ignacio , Bernús Miguel , Matheu M. Isabel , Maseras Feliu , Castillón Sergio , Díaz Yolanda 
Published: January 2018

AbstractRegio‐ and stereoselective oxyamination of dienes through a tandem rhodium‐catalysed aziridination–nucleophilic opening affords racemic oxazolidinone derivatives, which undergo a kinetic resolution acylation process with amidine‐based catalysts (ABCs) to achieve s values of up to 117. This protocol was applied to the enantioselective synthesis of sphingosine.
Structural Factors Affecting Binding of Platinum Anticancer Agents with Phospholipids: Influence of Charge and Phosphate Clamp Formation
Authors: Gorle Anil Kumar , Zhang Junyong , Liu Qin , Berners‐Price Susan J. , Farrell Nicholas P. 
Published: January 2018

AbstractWe report a detailed NMR and DFT study of the interaction of polynuclear platinum anticancer agents (PPCs) with negatively charged phospholipids as a mechanism for their cellular uptake. The reactions of fully 15N‐labelled [{trans‐PtCl(NH3)2}2(μ‐trans‐Pt(NH3)2{NH2(CH2)6NH2}2)]4+ (15N‐1, 1,0,1/t,t,t) and the dinuclear [{trans‐PtCl(NH3)2}2{μ‐H2N(CH2)6NH2}]2+ (15N‐2, 1,1/t,t) with the sodium salt of 1,2‐dihexanoyl‐sn‐glycero‐3‐phosphate (DHPA) were studied at 298 K, pH ≈5.4, by [1H,15N] HSQC 2D NMR spectroscopy. Both 15N‐1 and 15N‐2 form an initial mono‐adduct in which the DHPA is coordinated via the phosphate O atom. For the dinuclear 15N‐2, coordination of a second DHPA, in two different orientations, leads to two conformers of the bifunctional adduct. For 15N‐1, coordination of the second DHPA allows the central {PtN4} coordination unit to bind electrostatically to two additional DHPA molecules via phosphate clamp interactions, in an extended network. For both 1,0,1/t,t,t (1) and 1,1/t,t (2), equilibrium conditions are obtained more slowly (>35 h) than in the presence of phosphate (12 h) and in each case the rate constant for the first step of DHPA binding (kL) is about 8 times higher than that for phosphate, whereas the rate constants for the reverse reactions are quite similar. Reaction of 15N‐1 with the sodium salt of 1,2‐dihexanoyl‐sn‐glycero‐3‐[phosphatidyl‐l‐serine] (DHPS) showed only minor adduct formation via coordination to the N‐donor atom of the phosphoserine group.
Techno‐economic Optimization of the Production Network for the Synthesis of Formic Acid from Renewables
Authors: Schack Dominik , Sundmacher Kai 
Published: January 2018

AbstractEin nachhaltiger Umgang mit stofflichen und energetischen Ressourcen wird immer wichtiger, daher wird hier die Ameisensäureproduktion basierend auf erneuerbaren Ressourcen untersucht. Wenn Erdgas als Rohstoffquelle und gleichzeitig erneuerbare Energiequellen genutzt werden, ist eine emissionsarme und ökonomisch sinnvolle Produktion möglich. Der vorgestellte Ansatz kann bei der Evaluierung von unterschiedlichen strategischen Konzepten im Kontext der Energiewende ein wichtiges Hilfsmittel sein, da das betrachtete Produktionsnetzwerk für unterschiedliche Zielmoleküle einfach anpassbar und erweiterbar ist.
Nested graphs: A model to efficiently distribute multi‐agent systems on HPC clusters
Authors: Rousset Alban , Herrmann Bénédicte , Lang Christophe , Philippe Laurent , Bride Hadrien 
Published: January 2018

SummaryComputational simulation is becoming increasingly important in numerous research fields. Depending on the modeled system, several methods such as differential equations or Monte‐Carlo simulations may be used to represent the system behavior. The amount of computation and memory needed to run a simulation depends on its size and precision, and large simulations usually lead to long runs, thus requiring to adapt the model to a parallel system. Complex systems are often simulated using multi‐agent systems (MASs). While linear system based models benefit from a large set of tools to take advantage of parallel resources, multi‐agent systems suffer from a lack of platforms that ease the use of such resources. In this paper, we propose the use of Nested Graphs for a new modeling approach that allows the design of large, complex, and multi‐scale multi‐agent models, which can efficiently be distributed on parallel resources. Nested Graphs are formally defined and are illustrated on the well‐known predator‐prey model. We also introduce PDMAS (parallel and distributed multi‐agent system): a platform that implements the Nested Graph modeling approach to ease the distribution of multi‐agent models on High Performance Computing clusters. Performance results are presented to validate the efficiency of the resulting models.
Dynamic data reallocation and replication over a cloud environment
Authors: Abdel Raouf Ahmed E. , Badr Nagwa L. , Tolba Mohamed F. 
Published: January 2018

SummaryThe performance and efficiency of the distributed database system (DDBS) design are dependent on proper data fragmentation, reallocation, and replication of global relations. In this research, a Cluster Based Distributed and Parallel Database System (CB‐DDBS) architecture over a cloud environment is proposed. The proposed CB‐DDBS architecture processes the client's query requests, which access the clustered DDBS from anywhere. It also allows vertical and horizontal fragmentation, allocation, and replication decisions to be taken statically at the initial stage of the design. In addition, it allows migration and/or replication decisions to be taken by each cluster independently of other clusters using the proposed Optimal Fragment Reallocation and Replication (OFRAR) Algorithm. The proposed CB‐DDBS architecture and the proposed OFRAR Algorithm are tested in both Amazon cloud environment and a simulated environment. Experimental results show that the proposed OFRAR Algorithm efficiently reduces the communication costs for typical access patterns, the overloads of the sites, and the frequency and time spent on fragment migration over the network sites by imposing a stricter condition for fragment reallocation and replication, resulting in a great overall improvement in the DDBS performance. It also shows that the proposed CB‐DDBS architecture results in a significant reduction of the execution time needed for the transactions and for noticing an error.
Petri net‐based deviation detection between a process model with loop semantics and event logs
Authors: Wang Lu , Du YuYue , Qi Man , Qi HongDa , He ZhaoYang 
Published: January 2018

SummaryInformation systems have been widely used to realize business processes. The business processes can be described by formal or semi‐formal models. In practice, there are a number of realistic processes involving loop semantics. As an insufficient design or improvement of the information system, event logs generated from these systems may not be consistent with the existing models. By comparing an existing process model with the event logs, we can detect inconsistencies called deviations and verify and extend the business process model. In this paper, some abnormal activities in business processes are formally defined based on Petri nets. An efficient approach to detect deviations between the process model with loop structures and event logs is proposed. A clinical process in a healthcare information system is used as a case study to illustrate our work. Experimental results show the effectiveness and efficiency of the presented approach.
Food specific inhibitory control under negative mood in binge‐eating disorder: Evidence from a multimethod approach*
Authors: Leehr Elisabeth J. , Schag Kathrin , Dresler Thomas , Grosse‐Wentrup Moritz , Hautzinger Martin , Fallgatter Andreas J. , Zipfel Stephan , Giel Katrin E. , Ehlis Ann‐Christine 
Published: January 2018

AbstractObjectiveInhibitory control has been discussed as a developmental and maintenance factor in binge‐eating disorder (BED). The current study is the first aimed at investigating inhibitory control in a negative mood condition on a psychophysiological and behavioral level in BED with a combination of electroencephalography (EEG) and eye tracking (ET).MethodWe conducted a combined EEG and ET study with overweight individuals with BED (BED+,n = 24, mean age = 31, mean BMI = 35 kg/m2) and without BED (BED–,n = 23, mean age = 28, mean BMI = 35 kg/m2) and a normal‐weight (NWC,n = 26, mean age 28, mean BMI = 22 kg/m2) control group. We assessed self‐report data regarding impulsivity and emotion regulation as well as the processing of food stimuli under negative mood in an antisaccade task. Main outcome variables comprise event‐related potentials (ERP) regarding conflict processing (N2) and performance monitoring (error‐related negativity [ERN/Ne]) assessed by EEG and inhibitory control (errors in the first and second saccade) assessed by ET.ResultsBED+ patients reported increased impulsivity and higher emotion regulation difficulties compared with the other groups. The eye tracking data revealed impaired inhibitory control in BED+ compared with both control groups. Further, we found preliminary evidence from EEG recordings that conflict processing might be less thorough in the BED+ sample as well as in the NWC sample. In the BED+ sample this might be connected to the inhibitory control deficits on behavioral level. While the BED− sample showed increased conflict processing latencies (N2 latencies), which might indicate a compensation mechanism, the BED+ sample did not show such a mechanism. Performance monitoring (ERN/Ne latencies and amplitudes) was not impaired in the BED+ sample compared with both control samples.DiscussionParticipants with BED reported higher impulsivity and lower emotion regulation capacities. The combined investigation of electrocortical processes and behavior contributes to an advanced understanding of behavioral and electrocortical processes underlying inhibitory control in BED. Inhibitory control and negative mood, probably amplified by emotion regulation deficits, should be addressed further in the investigation and treatment of BED.
Cue reactivity, habituation, and eating in the absence of hunger in children with loss of control eating and attention‐deficit/hyperactivity disorder
Authors: Hilbert Anja , Kurz Susanne , Dremmel Daniela , Weihrauch Blüher Susann , Munsch Simone , Schmidt Ricarda 
Published: January 2018

AbstractObjectiveChildhood loss of control (LOC) eating and attention‐deficit/hyperactivity disorder (ADHD) are highly comorbid conditions and present with disordered eating behaviors, such as overeating. This study sought to delineate shared and specific abnormalities in physiological, cognitive‐motivational, and behavioral components of food‐specific impulsivity in children with LOC eating and ADHD. Specifically, children's reactivity and habituation to food and eating in the absence of hunger were examined.MethodsWithin this community‐based study, four groups of 8–13‐year‐old children with LOC eating (n = 24), ADHD (n = 32), comorbid LOC eating/ADHD (n = 9), and matched controls (n = 34) received a standard laboratory test meal to establish satiety and were then exposed to their favorite snack food in a cue exposure/reactivity trial, while salivation and desire to eat were repeatedly assessed. Subsequently, they were offered a variety of snack foods ad libitum.ResultsChildren with LOC eating, ADHD, and LOC/ADHD did not differ from controls in salivary reactivity and habituation to food cues. Children with LOC eating and ADHD showed greater cue reactivity of the desire to eat than controls, but groups did not differ in its longer‐term increments. At free access, only children with LOC/ADHD consumed significantly more energy than controls. Longer‐term increments of desire to eat predicted greater energy intake beyond LOC/ADHD group status.DiscussionDesire to eat among children with comorbid LOC eating and ADHD was associated with overeating in the absence of hunger, which may contribute to excess weight gain. Delineation of the specific features of childhood LOC eating versus ADHD warrants further study.
Influence of High Pressure Homogenization on Free Fatty Acid Formation in Nannochloropsis sp.
Authors: Balduyck Lieselot , Bruneel Charlotte , Goiris Koen , Dejonghe Céline , Foubert Imogen 
Published: January 2018

Although Nannochloropsis lipids have many potential applications in biofuels and high value products, their extraction is limited by the tough cell wall of this species. High pressure homogenization (HPH) can be used to improve the extraction efficiency. However, this can possibly induce free fatty acid (FFA) formation, which has a negative impact on oil quality. In this study, the HPH pressure and number of passes are varied in a full factorial design to study the impact of these factors on FFA formation, lipid extraction efficiency, and fatty acid profile. It is found that substantial amounts of FFA are formed during HPH treatments when compared to the non‐disrupted biomass. The FFA formation is mostly influenced by the number of passes applied, which can explained by a combined effect of the longer time residing as a wet paste and the temperature increase during the treatment. The large amount of FFA formed during the least intensive HPH treatment is in contrast with only a slight increase of the lipid extraction efficiency, which indicates that minor damage to the cell is sufficient to induce lipolytic reactions. The relative fatty acid profile after HI extraction is not influenced by the HPH treatment.Practical Applications: These results have important implications for the application of HPH treatments on microalgae with the aim to improve the extraction efficiency. It is demonstrated that more intensive HPH treatments with several passes are necessary to improve the extraction efficiency of Nannochloropsis lipids. However, the least intensive HPH treatments (1 pass at 400 bar) already induced the formation of substantial amounts of FFA. Consequently, to produce a biomass with a low FFA content and a high lipid extraction efficiency, a compromise should thus be made.High pressure homogenization (HPH) can efficiently be used to improve the extraction effiency of interesting compounds from Nannochloropsis cells. However, this treatment also induces the formation of free fatty acids (FFA), which have a negative influence on oil quality.
Temporal and spatial adjustments of channel migration and planform geometry: responses to ENSO driven climate anomalies on the tropical freely‐meandering Aguapeí River, São Paulo, Brazil
Authors: Suizu Tainá Medeiros , Nanson Gerald C. 
Published: January 2018

AbstractTwo reaches of Aguapeí River, a left‐bank tributary of the Paraná River in western São Paulo state, Brazil, were studied with the objective of assessing the role of bend curvature on channel migration in this wet‐tropical system and examining if land‐use changes or ENSO (El Niño Southern Oscillation) driven climate anomalies over nearly half a century have changed migration behaviour and planform geometry. Meander‐bend migration rates and morphometric parameters including meander‐bend curvature, sinuosity, meander wavelength and channel width, were measured and the frequency of bend cutoffs was analysed in order to determine the rate of change of channel adjustment over a 48 year period to 2010. Results show that maximum average channel migration rates occur in bends with curvatures of about 2–3 rc/w, similar to other previously studied temperate and subarctic freely meandering rivers although not as pronounced and with a tendency to favour tighter curvature. From 1962 to 2010 the Aguapeí River has undergone a significant reduction in sinuosity, a shift from tightly curving to more open bends, an overall decline in channel migration rates, an associated decrease in the frequency of neck‐cutoffs and an overall increase in channel width. As the majority of the drainage basin (96%) was already deforested in 1962, channel form and process changes were, unlike an interpretation for an adjacent river system, not attributed to altered land‐use but rather to a sharp ENSO‐driven increase in the magnitude of peak flow‐discharges of some 32% since 1972. In summary, this research revealed that recent climate and associated flow regime changes are having a pronounced effect on river channel behaviour in the Aguapeí River investigated here. Copyright © 2018 John Wiley & Sons, Ltd.
Assessing and mitigating simulated population-level effects of 3 herbicides to a threatened plant: Application of a species-specific population model of Boltonia decurrens
Authors: Schmolke Amelie , Brain Richard , Thorbek Pernille , Perkins Daniel , Forbes Valery 
Published: January 2018

Abstract

Extrapolating from organism-level endpoints, as generated from standard pesticide toxicity tests, to populations is an important step in threatened and endangered species risk assessments. We apply a population model for a threatened herbaceous plant species, Boltonia decurrens, to estimate the potential population-level impacts of 3 herbicides. We combine conservative exposure scenarios with dose–response relationships for growth and survival of standard test species and apply those in the species-specific model. Exposure profiles applied in the B. decurrens model were estimated using exposure modeling approaches. Spray buffer zones were simulated by using corresponding exposure profiles, and their effectiveness at mitigating simulated effects on the plant populations was assessed with the model. From simulated exposure effects scenarios that affect plant populations, the present results suggest that B. decurrens populations may be more sensitive to exposures from herbicide spray drift affecting vegetative stages than from runoff affecting early seedling survival and growth. Spray application buffer zones were shown to be effective at reducing effects on simulated populations. Our case study demonstrates how species-specific population models can be applied in pesticide risk assessment to bring organism-level endpoints, exposure assumptions, and species characteristics together in an ecologically relevant context. Environ Toxicol Chem 2018;37:1545–1555. © 2018 SETAC