bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Solvent Evaporation Rate in the Preparation of Carbon‐Coated Lithium Iron Phosphate Cathode Films on Battery Performance
Authors: Gören Attila , Cíntora‐Juárez Daniel , Martins Pedro , Ferdov Stanislav , Silva Maria Manuela , Tirado José Luís , Costa Carlos M. , Lanceros‐Méndez Senentxu 
Published: December 2015

AbstractIn this work, the drying step for cathodes based on carbon‐coated LiFePO4 prepared in the temperature range of 60–120 °C has been investigated in detail. The microstructure of the cathode shows a homogeneous distribution of the active material and conductive additive particles independent of the drying temperature. However, the results of impedance spectroscopy and cycling voltammetry are affected by the drying temperature. The solvent evaporation temperature, therefore, affects the polymer binder distribution and its characteristics, which include the polar phase content of the polymer and its affinity with the other components of the cathode. The discharge capacity value after 50 cycles is 120 and 81 mAh g−1 for the samples dried at 80 and 60 °C, respectively, which show the best and worst battery performance, respectively. It was concluded that carbon‐coated LiFePO4 cathodes should be prepared at drying temperatures between 80 and 100 °C for optimized performance.
A local mesh refinement approach for large‐eddy simulations of turbulent flows
Authors: Cevheri M. , McSherry R. , Stoesser T. 
Published: December 2015

SummaryIn this paper, a local mesh refinement (LMR) scheme on Cartesian grids for large‐eddy simulations is presented. The approach improves the calculation of ghost cell pressures and velocities and combines LMR with high‐order interpolation schemes at the LMR interface and throughout the rest of the computational domain to ensure smooth and accurate transition of variables between grids of different resolution. The approach is validated for turbulent channel flow and flow over a matrix of wall‐mounted cubes for which reliable numerical and experimental data are available. Comparisons of predicted first‐order and second‐order turbulence statistics with the validation data demonstrated a convincing agreement. Importantly, it is shown that mean streamwise velocities and fluctuating turbulence quantities transition smoothly across coarse‐to‐fine and fine‐to‐coarse interfaces. © 2016 The Authors International Journal for Numerical Methods in Fluids Published by John Wiley & Sons Ltd
Improving patient outcomes through multidisciplinary treatment planning conference
Authors: Lewis Carol M. , Nurgalieva Zhannat , Sturgis Erich M. , Lai Stephen Y. , Weber Randal S. 
Published: December 2015

ABSTRACTBackgroundThe purpose of this study was for us to determine National Comprehensive Cancer Network (NCCN) guideline‐compliance of multidisciplinary conference (MDC) recommendations and actual treatment received, and to determine this impact on patient outcomes.MethodsWe conducted a retrospective review of patients presented at MDC between January 1, 2006, and December 31, 2006, with previously untreated incident cancers.ResultsWe identified 232 patients, for whom MDC recommendations were NCCN guideline‐compliant in 201 (86.6%). Actual treatment was NCCN guideline‐compliant in 170 of 197 patients (86.3%). Adherence of MDC recommendations to NCCN guidelines was associated with superior overall survival (hazard ratio [HR] = 0.69; 95% confidence interval [CI] = 0.33–1.39; p = .3), as was guideline‐compliance of actual treatment (HR = 0.6; 95% CI = 0.64–1.07; p = .07); congruence between MDC recommendations and actual treatment conferred a statistically significant overall survival benefit (HR = 0.49; 95% CI = 0.27–0.89; p = .02).ConclusionOur findings argue for patient‐centered application of NCCN guidelines. Prospective evaluation will enable more timely identification of systematic NCCN guideline deviations that quality improvement interventions may address. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1820–E1825, 2016
Ecological risk assessment of boreal sediments affected by metal mining: Metal geochemistry, seasonality, and comparison of several risk assessment methods
Authors: Väänänen Kristiina , Kauppila Tommi , Mäkinen Jari , Leppänen Matti T , Lyytikäinen Merja , Akkanen Jarkko 
Published: December 2015

Abstract
The mining industry is a common source of environmental metal emissions, which cause long-lasting effects in aquatic ecosystems. Metal risk assessment is challenging due to variations in metal distribution, speciation, and bioavailability. Therefore, seasonal effects must be better understood, especially in boreal regions in which seasonal changes are large. We sampled 4 Finnish lakes and sediments affected by mining for metals and geochemical characteristics in autumn and late winter, to evaluate seasonal changes in metal behavior, the importance of seasonality in risk assessment, and the sensitivity and suitability of different risk assessment methods. We compared metal concentrations in sediment, overlying water, and porewater against environmental quality guidelines (EQGs). We also evaluated the toxicity of metal mixtures using simultaneously extracted metals and an acid volatile sulfides (SEM-AVS) approach together with water quality criteria (US Environmental Protection Agency equilibrium partitioning benchmarks). Finally, site-specific risks for 3 metals (Cu, Ni, Zn) were assessed using 2 biotic ligand models (BLMs). The metal concentrations in the impacted lakes were elevated. During winter stratification, the hypolimnetic O2 saturation levels were low (&lt;6%) and the pH was acidic (3.5–6.5); however, abundant O2 (&gt;89%) and neutral pH (6.1–7.5) were found after the autumnal water overturn. Guidelines were the most conservative benchmark for showing an increased risk of toxicity in the all of the lakes. The situation remained stable between seasons. On the other hand, SEM-AVS, equilibrium partition sediment benchmarks (ESBs), and BLMs provided a clearer distinction between lakes and revealed a seasonal variation in risk among some of the lakes, which evidenced a higher risk during late winter. If a sediment risk assessment is based on the situation in the autumn, the overall risk may be underestimated. It is advisable to carry out sampling and risk assessment during periods in which metals are assumed to be the most environmentally harmful. Integr Environ Assess Manag 2016;12:759–771. © 2015 SETAC
Temporary abdominal closure and delayed biliary reconstruction due to massive bleeding in patients undergoing liver transplantation: an old trick in a new indication
Authors: Komorowski Andrzej L. , Li Wei‐Feng , Millan Carlos A. , Huang Tun‐Sung , Yong Chee‐Chien , Lin Tsan‐Shiun , Lin Ting‐Lung , Jawan Bruno , Wang Chih‐Chi , Chen Chao‐Long 
Published: December 2015

AbstractBackgroundMassive bleeding during liver transplantation (LT) is difficult to manage surgical event. Perihepatic packing (PP) and temporary abdominal closure (TAC) with delayed biliary reconstruction (DBR) can be applied in these circumstances.MethodA prospective database of LT in a major transplant center was analyzed to identify patients with massive uncontrollable bleeding during LT that was resolved by PP, TAC, and DBR.ResultsFrom January 2009 to July 2013, 20 (3.6%) of 547 patients who underwent LT underwent DBR. Mean intraoperative blood loss was 20,500 ml at the first operation. The DBR was performed with a mean of 55.2 h (16–110) after LT. Biliary reconstruction included duct‐to‐duct (n = 9) and hepatico‐jejunostomy (n = 11). Complications occurred in eight patients and included portal vein thrombosis, cholangitis, severe bacteremia, pneumonia. There was one in‐hospital death. In the follow‐up of 18 to 33 months we have seen one patient died 9 months after transplantation. The remaining 18 patients are alive and well.ConclusionsIn case of massive uncontrollable bleeding and bowel edema during LT, the combined procedures of PP, TAC, and DBR offer an alternatively surgical option to solve the tough situation.
Ultrastructure of the fetal membranes of the oviparous kingsnake, Lampropeltis getula (Colubridae) as revealed by scanning electron microscopy
Authors: Kim Young K. , Blackburn Daniel G. 
Published: December 2015

ABSTRACTIn reptilian sauropsids, fetal (extraembryonic) membranes that line the eggshell sustain developing embryos by providing for gas exchange and uptake of water and eggshell calcium. However, a scarcity of morphological studies hinders an understanding of functional specializations and their evolution. In kingsnakes (Lampropeltis getula), scanning electron microscopy reveals two major fetal membranes: the chorioallantois and yolk sac omphalopleure. In early development, the chorioallantois contains tall chorionic epithelial cells, avascular connective tissue, and enlarged allantoic epithelial cells. During its maturation, the chorionic and allantoic epithelia thin dramatically and become underlain by a rich network of allantoic capillaries, yielding a membrane ideally suited for respiratory gas exchange. Yolk sac development initially is like that of typical lizards and snakes, forming an avascular omphalopleure, isolated yolk mass (IYM), and yolk cleft. However, unlike the situation in most squamates studied, the omphalopleure becomes transformed into a “secondary chorioallantois” via three asynchronous events: flattening of the epithelium, regression of the IYM, and vascularization by the allantois. Progressive expansion of chorioallantois parallels growing embryonic needs for gas exchange. In early through mid‐development, external surfaces of both the chorionic and omphalopleure epithelium show an abundance of irregular surface protrusions that possibly increase surface area for water absorption. We postulate that the hypertrophied allantoic epithelial cells produce allantoic fluid, a viscous substance that facilitates water uptake and storage. Our findings are consistent with a previous study on the corn snake Pantherophis guttatus, but include new observations and novel functional hypotheses relevant to a reconstruction of basal squamate patterns. J. Morphol. 276:1467–1481, 2015. © 2015 Wiley Periodicals, Inc.
Quality assessment of white mold‐ripened cheeses manufactured with different lactic cultures
Authors: Judacewski Priscila , Los Paulo R , Benvenutti Laís , Alberti Aline , Simões Deise RS , Nogueira Alessandro 
Published: December 2015

AbstractBACKGROUNDWhite mold‐ripened cheeses were investigated with the objective of proposing a colorimetric method to monitor the surface growth of Penicillium candidum and to evaluate the influence of the mesophilic (homofermentative (QMO) and heterofermentative (QMLD)) and thermophilic (QT) starter cultures on the physicochemical composition and sensory description.RESULTSThe whiteness index was effective in proving the appearance of superficial mycelium and the stability of white mold growth. The lactic cultures showed significant influence on most of the physicochemical analyses. The cheese made with thermophilic lactic culture had a 1 day gain in the growth of mycelium on the surface; nevertheless, the appearance of this product was potentially not acceptable for consumers. The heterofermentative mesophilic cheese had a better appearance and texture profile. However, the homofermentative mesophilic cheese showed aspects of fresh cheese and was acceptable for a wide range of consumers.CONCLUSIONThe whiteness index was efficient to monitor the surface growth of P. candidum. The highest proteolytic effect was found in the QMLD and QT cultures. However, the cheese elaborated with the QMLD culture showed the best sensory acceptance. © 2015 Society of Chemical Industry
Application of a Box–Behnken design for optimizing the extraction process of agave fructans (Agave tequilana Weber var. Azul)
Authors: Flores‐Girón Emmanuel , Salazar‐Montoya Juan Alfredo , Ramos‐Ramírez Emma Gloria 
Published: December 2015

AbstractBACKGROUNDAgave (Agave tequilana Weber var. Azul) is an industrially important crop in México since it is the only raw material appropriate to produce tequila, an alcoholic beverage. Nowadays, however, these plants have also a nutritional interest as a source of functional food ingredients, owing to the prebiotic potential of agave fructans. In this study, a Box–Behnken design was employed to determine the influence of temperature, liquid:solid ratio and time in a maceration process for agave fructan extraction and optimization.RESULTSThe developed regression model indicates that the selected study variables were statistical determinants for the extraction yield, and the optimal conditions for maximum extraction were a temperature of 60 °C, a liquid:solid ratio of 10:1 (v/w) and a time of 26.7 min, corresponding to a predicted extraction yield of 37.84%. Through selective separation via precipitation with ethanol, fructans with a degree of polymerization of 29.1 were obtained.CONCLUSIONBox–Behnken designs are useful statistical methods for optimizing the extraction process of agave fructans. A mixture of carbohydrates was obtained from agave powder. This optimized method can be used to obtain fructans for use as prebiotics or as raw material for obtaining functional oligosaccharides. © 2015 Society of Chemical Industry
A retrospective analysis on the management of pigmented lesions using a picosecond 755‐nm alexandrite laser in Asians
Authors: Chan Johnny Chun‐yin , Shek Samantha Yee‐nam , Kono Taro , Yeung Chi Keung , Chan Henry Hin‐lee 
Published: December 2015

Background and objectivesPhoto‐aging in Chinese often presents with benign pigmentary lesions. Q‐switched lasers for pigmentary lesions in Asians had reported a risk of post‐inflammatory hyperpigmentation (PIH) up to 25%. Longer pulse widths in the millisecond domains were advocated with reduced risk of PIH. Recently, picosecond lasers of various wavelengths were introduced with proven efficacy in tattoo removal. The objective of this study is to assess the efficacy and safety of a novel picosecond 755‐nm alexandrite laser for the treatment of benign pigmented lesions in Asians retrospectively.MethodsA list of all patients who received picosecond 755‐nm alexandrite laser treatment at a private dermatology center in Hong Kong was included. Those who had any other laser or topical treatment during the period of picosecond laser treatment were excluded. The age, skin phototype, type of pigmentary lesion, number of treatments performed was recorded. The baseline and most recent standardized photographs were assessed by trained physicians for comparison. A score of 0–4, representing poor 0–24%, fair 25–49%, good 50–74%, excellent 75–95%, and complete 95%+ improvement was given. Adverse events associated with the laser treatment were also recorded. All patients were followed up until 6 months after the last laser session.ResultsA total of 13 subjects were included in the present study. The number of treatment sessions received ranged from one to seven. The benign pigmentary lesions consist of Nevus of Ota, café‐au‐lait patches, lentigines, Becker's nevus, Hori's macules, and nevus spilus. Among patients with Nevus of Ota, one patient achieved complete clearance after four treatments and two other patients had excellent clearance after three and four sessions, respectively. Patients with café‐au‐lait had fair to good clearance after one to seven treatment sessions. One patient who has Hori's macules was resistant to laser treatments and a fair response was achieved after eight treatments. In the present series, two patients (4.8%) developed transient hypopigmentation, which had improved upon subsequent follow‐up in both cases and none had post‐inflammatory hyperpigmentation.ConclusionsThe novel picosecond 755‐nm alexandrine laser is effective for the treatment of benign pigmentary lesions in Chinese, especially for the clearance of Nevus of Ota. Picosecond laser appears to be associated with a much lower risk of PIH for treatment of pigmentary lesions in Asians. Lasers Surg. Med. 48:23–29, 2016. © 2015 Wiley Periodicals, Inc.
NIH working group report—using genomic information to guide weight management: From universal to precision treatment
Authors: Bray Molly S. , Loos Ruth J.F. , McCaffery Jeanne M. , Ling Charlotte , Franks Paul W. , Weinstock George M. , Snyder Michael P. , Vassy Jason L. , Agurs‐Collins Tanya ,   The Conference Working Group
Published: December 2015

ObjectivePrecision medicine utilizes genomic and other data to optimize and personalize treatment. Although more than 2,500 genetic tests are currently available, largely for extreme and/or rare phenotypes, the question remains whether this approach can be used for the treatment of common, complex conditions like obesity, inflammation, and insulin resistance, which underlie a host of metabolic diseases.MethodsThis review, developed from a Trans‐NIH Conference titled “Genes, Behaviors, and Response to Weight Loss Interventions,” provides an overview of the state of genetic and genomic research in the area of weight change and identifies key areas for future research.ResultsAlthough many loci have been identified that are associated with cross‐sectional measures of obesity/body size, relatively little is known regarding the genes/loci that influence dynamic measures of weight change over time. Although successful short‐term weight loss has been achieved using many different strategies, sustainable weight loss has proven elusive for many, and there are important gaps in our understanding of energy balance regulation.ConclusionsElucidating the molecular basis of variability in weight change has the potential to improve treatment outcomes and inform innovative approaches that can simultaneously take into account information from genomic and other sources in devising individualized treatment plans.
Decreased FOXJ1 expression and its ciliogenesis programme in aggressive ependymoma and choroid plexus tumours
Authors: Abedalthagafi Malak S , Wu Michael P , Merrill Parker H , Du Ziming , Woo Terri , Sheu Shu‐Hsien , Hurwitz Shelley , Ligon Keith L , Santagata Sandro 
Published: December 2015

AbstractWell‐differentiated human cancers share transcriptional programmes with the normal tissue counterparts from which they arise. These programmes broadly influence cell behaviour and function and are integral modulators of malignancy. Here, we show that the master regulator of motile ciliogenesis, FOXJ1, is highly expressed in cells along the ventricular surface of the human brain. Strong expression is present in cells of the ependyma and the choroid plexus as well as in a subset of cells residing in the subventricular zone. Expression of FOXJ1 and its transcriptional programme is maintained in many well‐differentiated human tumours that arise along the ventricle, including low‐grade ependymal tumours and choroid plexus papillomas. Anaplastic ependymomas as well as choroid plexus carcinomas show decreased FOXJ1 expression and its associated ciliogenesis programme genes. In ependymomas and choroid plexus tumours, reduced expression of FOXJ1 and its ciliogenesis programme are markers of poor outcome and are therefore useful biomarkers for assessing these tumours. Transitions in ciliogenesis define distinct differentiation states in ependymal and choroid plexus tumours with important implications for patient care. Copyright © 2015 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Photoluminescence and electroluminescence imaging of perovskite solar cells
Authors: Hameiri Ziv , Mahboubi Soufiani Arman , Juhl Mattias K. , Jiang Liangcong , Huang Fuzhi , Cheng Yi‐Bing , Kampwerth Henner , Weber Juergen W. , Green Martin A. , Trupke Thorsten 
Published: December 2015

AbstractFast camera‐based luminescence‐imaging measurements on perovskite solar cells are presented. The fundamental correlation between the luminescence intensity and the open circuit voltage predicted by the generalised Planck law is confirmed, enabling various quantitative methods for the detection of efficiency‐limiting defects to be applied to this new cell structure. Interstinegly, it is found that this fundamental correlation is valid only for light‐soaked devices. Copyright © 2015 John Wiley & Sons, Ltd.
Statin use and risk of disease recurrence and death after radical prostatectomy
Authors: Keskiväli Teemu , Kujala Paula , Visakorpi Tapio , Tammela Teuvo L. J. , Murtola Teemu J. 
Published: December 2015

BACKGROUNDStatins have been linked with improved prostate cancer survival and lower risk of recurrence in men treated with radiation therapy. However, the association is unclear for surgically‐treated men. We studied the risk of prostate cancer recurrence and death by statin usage after radical prostatectomy in a cohort of prostate cancer patients treated with radical prostatectomy.METHODSA cohort of 1,314 men who underwent curative‐intent radical prostatectomy at the Tampere University Hospital, Tampere, Finland during 1995–2009 were linked to national prescription database to obtain detailed information on statin purchases. The risk of PSA recurrence and death (overall and prostate cancer‐specific) by statin use before and after the surgery were evaluated using Cox regression with model adjustment for tumor characteristics, total cholesterol and simultaneous use of antidiabetic and antihypertensive drugs. Tissue expression of putative prognostic markers were measured from a subgroup of 323 men.RESULTSDuring the median follow‐up of 8.6 years after surgery 484 men recurred, while 244 men died (32 due to prostate cancer). In general statin use before or after prostatectomy was not associated with risk of disease recurrence or death. Tissue expression of Ki‐67 and ERG modified the association between statin use and risk of disease recurrence; the risk estimates were lower in men with Ki‐67 expression above the median (P for interaction 0.001 and 0.004 for statin use before and after prostatectomy, respectively) and no ERG expression in the tumor tissue (P for interaction 0.006 and 0.011).CONCLUSIONSStatin use generally did not affect prostate cancer prognosis after prostatectomy. The effect on disease recurrence may depend on tumor properties, such as proliferation activity. Thus possible future prospective studies should recognize and enroll subgroups of prostate cancer patients most likely to benefit from statins. Prostate 76:469–478, 2016. © 2015 Wiley Periodicals, Inc.