bluuebunny/crossref_metadata_2025_split huggingface dataset:
Verbeelding en veiligheid
Authors: de Mare Heidi 
Published: July 2016

Imagination and safety: The film Project X and the riots in Haren (2012)
On September 21th 2012, a sweet sixteen party in Haren (a Dutch village), announced on Facebook as PROJECT X Haren, turned into a riot in which youngsters clashed with the police. The blame was put on the film Project X (2012) that would have inspired adolescents to become aggressive and violent. However, like other adolescent comedies, this movie offers an insight in the adolescent state of mind, the role of humor and their lack of risk assessments. Much violence is (harmless) slapstick-like, boundaries are exceeded (sex, alcohol, drugs) and transgression is often directed against parents, teachers and the police. What is tested in the adolescent imagination is the public order. Film functions as a symbolic rite of passage, with carnivalesque inversions. Reacting in Haren on this adolescent state of mind with an administrative prohibition (‘there is no party’) confirmed the juvenile joke. Acting as if it is not a party but a huge disaster (by enlarging police forces) contributed to make the riot a reality that the youngsters themselves never imagined. The commission of inquiry recommends taking serious film and other forms of public imagination, because they contribute to our understanding of reality, especially concerning the perceptions of societal actors.
Functional Maturation of Induced Pluripotent Stem Cell Hepatocytes in Extracellular Matrix—A Comparative Analysis of Bioartificial Liver Microenvironments
Authors: Wang Bo , Jakus Adam E. , Baptista Pedro M. , Soker Shay , Soto-Gutierrez Alejandro , Abecassis Michael M. , Shah Ramille N. , Wertheim Jason A. 
Published: July 2016

Abstract

Induced pluripotent stem cells (iPSCs) are new diagnostic and potentially therapeutic tools to model disease and assess the toxicity of pharmaceutical medications. A common limitation of cell lineages derived from iPSCs is a blunted phenotype compared with fully developed, endogenous cells. We examined the influence of novel three-dimensional bioartificial microenvironments on function and maturation of hepatocyte-like cells differentiated from iPSCs and grown within an acellular, liver-derived extracellular matrix (ECM) scaffold. In parallel, we also compared a bioplotted poly-l-lactic acid (PLLA) scaffold that allows for cell growth in three dimensions and formation of cell-cell contacts but is infused with type I collagen (PLLA-collagen scaffold) alone as a “deconstructed” control scaffold with narrowed biological diversity. iPSC-derived hepatocytes cultured within both scaffolds remained viable, became polarized, and formed bile canaliculi-like structures; however, cells grown within ECM scaffolds had significantly higher P450 (CYP2C9, CYP3A4, CYP1A2) mRNA levels and metabolic enzyme activity compared with iPSC hepatocytes grown in either bioplotted PLLA collagen or Matrigel sandwich control culture. Additionally, the rate of albumin synthesis approached the level of primary cryopreserved hepatocytes with lower transcription of fetal-specific genes, α-fetoprotein and CYP3A7, compared with either PLLA-collagen scaffolds or sandwich culture. These studies show that two acellular, three-dimensional culture systems increase the function of iPSC-derived hepatocytes. However, scaffolds derived from ECM alone induced further hepatocyte maturation compared with bioplotted PLLA-collagen scaffolds. This effect is likely mediated by the complex composition of ECM scaffolds in contrast to bioplotted scaffolds, suggesting their utility for in vitro hepatocyte assays or drug discovery.

Significance
Through the use of novel technology to develop three-dimensional (3D) scaffolds, the present study demonstrated that hepatocyte-like cells derived via induced pluripotent stem cell (iPSC) technology mature on 3D extracellular matrix scaffolds as a result of 3D matrix structure and scaffold biology. The result is an improved hepatic phenotype with increased synthetic and catalytic potency, an improvement on the blunted phenotype of iPSC-derived hepatocytes, a critical limitation of iPSC technology. These findings provide insight into the influence of 3D microenvironments on the viability, proliferation, and function of iPSC hepatocytes to yield a more mature population of cells for cell toxicity studies and disease modeling.
Proyecto de Investigación sobre la recepción del Concilio Vaticano II
Authors: Zolezzi Pb. Tibaldo , Navarro Jessica 
Published: July 2016

Este artículo recoge lo más relevante de una investigación realizada por docentes del Instituto de Estudios Teológicos de la Universidad Católica de Temuco. En ocasión de la celebración de loscincuenta años del comienzo de los trabajos del Concilio Vaticano II han querido reconocer, a partir de la percepción de protagonistas de la vida eclesial de las diócesis del sur de Chile, las implicancias de esteConcilio en la vida de la Iglesia Católica contemporánea. A través de consultas, entrevistas y diálogos se ha logrado determinar aspectos relevantes de la recepción del Vaticano II, de los aciertos y deficiencias que ha tenido la misma, así como también la existencia de aspectos que aún están pendientes de ser acogidos en la vida de la Iglesia
Mi propuesta para el Coloquio. Conferencia inaugural
Authors: Silva Sergio 
Published: July 2016

En la conferencia inaugural del XIV Coloquio de Teología, el autor reflexiona sobre las propuestas del Concilio Vaticano II que aun después de varias décadas desafían a la Iglesia para su aplicación. Estos afectan a la vida interna de la Iglesia los que se expresan principalmente en temas eclesiológicos y litúrgicos, pero también al modo en que ella se relaciona con el mundo a través de su misión, la que consiste en llevar el Evangelio a toda cultura para encontrar en ella las semillas del verbo.
Los desafíos pastorales de la familia en el contexto de la evangelización: A la espera de una «buena noticia» para las parejas y para las familias
Authors: Corpas de Posada Isabel 
Published: July 2016

Las últimas asambleas sinodales han referido a la familia, en este sentido, la reflexión sobre los problemas y especialemente sobre los desafíos que ofrece a la Iglesia en el context de la Evangelización merecen cada vez más una propuesta de acción y reflexión.
Propuesta de itinerario de acompañamiento para estudiantes embarazadas y padres adolescentes, en torno a la orientación vocacional y proyecto de vida
Authors: Nolasco Mendoza Julia 
Published: July 2016

Luego de su práctica profesional en el Liceo municipal de Perquenco que puede ser un modelo de experiencia en el desafío de acompar a adolescentes embarazadas, la autora hace una propuesta de itinerario de acompañamiento para estudiantes embarazadas y padres adolescentes, en torno a la orientación vocacional y proyecto de vida. Incluye la propuesta algunas fichas de trabajo personal y de crecmiento en la conciencia de cuidar la propia vida y la del hijo que está por nacer.
The Catalytic, Enantioselective Michael Reaction
Authors: Reyes Efraím , Uria Uxue , Vicario Jose L. , Carrillo Luisa 
Published: July 2016

AbstractThe catalytic enantioselective Michael reaction is the conjugate addition of a resonance‐stabilized carbanion to an electron‐poor olefin (an αβ‐unsaturated carbonyl compound or a related derivative) mediated by substoichiometric amounts of a chiral catalyst that enables stereocontrol in the newly generated stereocenter(s). This reaction allows the direct enantioselective construction of substituted 1,5‐dicarbonyl compounds or related architectures through the appropriate selection of the enolizable carbonyl compound employed as pronucleophile and the Michael acceptor. A variety of catalyst architectures have been described that make it possible to carry out this reaction with superior levels of chemical efficiency and high enantio‐ and stereocontrol, and also under conditions that tolerate a wide variety of functional groups. Both transition metal catalysis and organocatalysis have been employed as methodological approaches for carrying out this reaction in an enantioselective manner.This chapter describes different catalytic systems and methods developed for achieving enantioselective Michael reactions through the end of 2012, including a detailed mechanistic explanation of the different generic modes of substrate activation operating with each type of catalyst and their associated stereochemical aspects. The intention is to provide researchers interested in applying this methodology to their own synthetic strategies with a suitable starting point for identifying an efficient synthetic approach. In addition, the preparation of selected catalysts that are excellent for a particular pairing of substrates in this reaction, together with practical experimental protocols are described and some examples in which these methodologies have been applied to total synthesis have been included. This chapter is limited exclusively to those examples in which the final Michael addition product is obtained after protonation of the conjugate addition intermediate and therefore, tandem, domino, or cascade processes initiated by Michael reactions lie outside the scope of this work.Supplemental references are provided for articles published after the 2012 cut‐off date through the first half of 2015.
Two interacting X lines in magnetotail: Evolution of collision between the counterstreaming jets
Authors: Alexandrova Alexandra , Nakamura Rumi , Panov Evgeny V. , Sasunov Yury L. , Nakamura Takuma , Vörös Zoltán , Retinò Alessandro , Semenov Vladimir S. 
Published: July 2016

AbstractWe study the process of collision between the counterstreaming jets flowing out from two reconnection sites in the Earth's magnetotail. The X lines, bracketing the region of jets collision, were passing by two Cluster probes successively in tailward direction. Two probes observed two different stages of the collision process. At the jets collision site, a probe first observed an ion‐scale current sheet‐like structure, while the other probe observed more compressed one later. The strong wave activities on both ion and electron scales were seen within the compressed layer. Such evolution of the jets collision resulting in the formation of the compressed boundary between the active X lines shows an example of interaction between the X lines during multiple reconnection.
Focal mechanisms and size distribution of earthquakes beneath the Krafla central volcano, NE Iceland
Authors: Schuler Juerg , Pugh David J. , Hauksson Egill , White Robert S. , Stock Joann M. , Brandsdóttir Bryndís 
Published: July 2016

AbstractSeismicity was monitored beneath the Krafla central volcano, NE Iceland, between 2009 and 2012 during a period of volcanic quiescence, when most earthquakes occurred within the shallow geothermal field. The highest concentration of earthquakes is located close to the rock‐melt transition zone as the Iceland Deep Drilling Project‐1 (IDDP‐1) wellbore suggests and decays quickly at greater depths. We recorded multiple swarms of microearthquakes, which coincide often with periods of changes in geothermal field operations, and found that about one third of the total number of earthquakes are repeating events. The event size distribution, evaluated within the central caldera, indicates average crustal values withb= 0.79 ± 0.04. No significant spatialb value contrasts are resolved within the geothermal field nor in the vicinity of the drilled melt. Besides the seismicity analysis, focal mechanisms are calculated for 342 events. Most of these short‐period events have source radiation patterns consistent with double‐couple (DC) mechanisms. A few events are attributed to non‐shear‐faulting mechanisms with geothermal fluids likely playing an important role in their source processes. Diverse faulting styles are inferred from DC events, but normal faulting prevails in the central caldera. The best fitting compressional and tensional axes of DC mechanisms are interpreted in terms of the principal stress or deformation rate orientations across the plate boundary rift. Maximum compressive stress directions are near‐vertically aligned in different study volumes, as expected in an extensional tectonic setting. Beneath the natural geothermal fields, the least compressive stress axis is found to align with the regional spreading direction. In the main geothermal field both horizontal stresses appear to have similar magnitudes causing a diversity of focal mechanisms.
Autonomous Parachute‐Based Precision Delivery Systems
Authors: Yakimenko Oleg A. 
Published: July 2016

Abstract
Introduction of a ram‐air parafoil possessing the steering and rate‐of‐descent control authority sparked a great interest of using them for autonomous precision payload delivery. A technological revolution of 1990s enabled the usage of relatively inexpensive powerful computer and miniature sensors including Global Positioning System receiver as a part of airborne guidance unit, processing all available data and producing corrective commands in real time. This chapter presents the current state of the art in aerial precision payload delivery starting from the concept of operations and key performance requirements and continuing with an overview of a variety of different‐weight systems that were developed and fielded within the Joint Precision Airdrop System program led by the US Army and US Air Force. Compared to uncontrolled round parachutes, these systems allowed reducing a touchdown error by an order of magnitude. The chapter further describes key elements of modeling of controlled parachute systems and designing guidance, navigation, and control architecture for them. The chapter concludes with presenting some latest developments and cost‐effective alternatives involving traditional parachutes with added limited control authority.
Operational Profiles of Unmanned Aircraft Systems in the Context of the
US
Regulatory Regime
Authors: Mueller Eric 
Published: July 2016

Abstract
This chapter describes current and future unmanned aircraft system (UAS) operations in the context of the regulatory regime that governs their use. Because the uses of UAS are inextricably linked to the ways in which they receive airworthiness and operational approval, it is challenging to understand how UAS are and will be used without an understanding of that regime. The use of a certificate of authorization or waiver process for public entities is described, followed by a review of the airworthiness approval process for civil operators using “Section 333 exemptions.” A description of the long‐standing rules that have been in place for model aircraft hobbyists is also presented. Next, current UAS operations under these regulatory regimes are reviewed. Public and civil uses of UAS are described through examination of the publicly available approvals the FAA has provided, while hobbyist operations are described from a review of tens of thousands of UAS flights uploaded to an online drone community. The chapter identifies three regulatory regimes that have been proposed or are being developed, and then describes the types of operations that could be enabled by one or more of the regimes. These new operations are based on data collection needs for experts in non‐UAS fields rather than missions proposed by those who operate UAS directly.
Standards and Interoperability: A Systems Engineering Perspective
Authors: Yu Andy , Mockus Linas , DeLaurentis Dan 
Published: July 2016

Abstract
As the diversity of aircraft systems seeking integration into the air transportation system grows, interoperability is emerging as a key requirement throughout the design process and life cycle. The growth of UAS applications offers a prime example. While seemingly straightforward, interoperability varies extensively in meaning and context. To paint a clear picture, this chapter will provide a background on the history, concepts, and challenges in interoperability from a systems engineer's perspective. Rather than pursuing a deeply detailed review on interoperability, this chapter will highlight some commonly used standards for unmanned systems and implications of various mechanical, electrical, information, and programming principles. The chapter will also explain various types or levels of interoperability and reflect on their significance to different stakeholders, importance to system requirements, modeling frameworks for future and legacy systems, and criterion for acceptable interoperability practices. While this chapter may focus on UAS, several examples will also reference software, hardware, and policy.
Copper‐Catalyzed Regioselective Cascade Alkylation and Cyclocondensation of Quinoline N‐Oxides with Diazo Esters: Direct Access to Conjugated π‐Systems
Authors: Biswas Aniruddha , Karmakar Ujjwal , Pal Arun , Samanta Rajarshi 
Published: July 2016

AbstractAn inexpensive copper‐catalyzed cascade regioselective alkylation, followed by cyclocondensation of quinoline N‐oxides with α‐diazo esters has been achieved successfully to provide heteroarene‐containing conjugated π‐systems. The developed method is simple, straightforward, and economical with a broad range of substrate scope. The dual role of copper catalyst in the C−H bond functionalization and in Lewis acid‐promoted cyclization was explored.
Trends and disparities in disordered eating among heterosexual and sexual minority adolescents
Authors: Watson Ryan J. , Adjei Jones , Saewyc Elizabeth , Homma Yuko , Goodenow Carol 
Published: July 2016

ABSTRACTObjectiveDisordered eating has decreased for all youth over time, but studies have not focused specifically on lesbian, gay, and bisexual (LGB) youth. Research has found that LGB youth report disordered eating behaviors more often compared to their heterosexual counterparts, but no studies have documented trends over time for LGB youth and considered whether these disparities are narrowing or widening across sexual orientation groups.MethodWe use pooled data from the 1999 to 2013 Massachusetts Youth Risk Behavior Surveys (N = 26,002) to investigate trends in purging, fasting, and using diet pills to lose or control weight for heterosexual and sexual minority youth. We used crosstabs, logistic regression, and interactions in regression models, stratified by sex.ResultsThe prevalence of disordered eating has decreased on all three measures across nearly all groups of heterosexual and sexual minority youth. However, we found disparities in reported disordered eating behaviors for LGB youth persisted across all survey years, with LGB students reporting significantly higher prevalence of disordered eating than heterosexuals. The disparities in fasting to control weight widened between the first and last survey waves between lesbian adolescents and heterosexual females.DiscussionThe significant reductions over time in prevalence of disordered eating among some youth are encouraging, but the disparities remain. Indeed, the increasing prevalence of fasting, diet pill use, and purging to control weight among lesbians may warrant targeted prevention and intervention programs. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2017; 50:22–31)
Eugenyl acetate inhibits growth and virulence factors of drug‐resistant Acinetobacter baumannii
Authors: Syed Musthafa Khadar , Voravuthikunchai Supayang Piyawan 
Published: July 2016

AbstractAcinetobacter baumannii is an opportunistic Gram‐negative pathogenic bacterium causing hospital‐acquired infections in immunocompromised patients and leads to high death rates, worldwide. The occurrence of resistance development by the organism to current therapeutic measures necessitates safe and alternative treatment strategy. Eugenyl acetate, an aromatic component of clove essential oil, exhibits various pharmacological activities. Therefore, in this study, as a suitable substitute for existing treatment approaches, we evaluated the prospective of eugenyl acetate as an antibacterial and anti‐virulence agent against drug‐resistant A. baumannii clinical isolates. The minimum inhibitory concentration (MIC) of the compound against the clinical isolates (n = 20) was found to be in the range between 0.05% and 0.4% v/v. In time‐kill assay, eugenyl acetate at 1× MIC retarded the growth of the isolates and inhibited further proliferation. Moreover, a significant inhibition in the growth‐dependent reduction of 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide by A. baumannii was observed upon treatment with eugenyl acetate, compared with no effects observed with ampicillin (P < 0.01). Scanning electron microscopic studies demonstrated cell rupture, wrinkled cell morphology, and an irregular shape of the bacterial cells upon treatment with the compound. Eugenyl acetate at sub‐MIC (0.025% v/v) exhibited anti‐virulence effects by reducing motility and protease production by A. baumannii. The percentage motility inhibitory effects of the compound ranged from 75.63% to 87.20%, significantly different from the control (P < 0.01). Furthermore, the compound reduced proteolytic activity of the isolates in the range of 50.81% to 92.66%. The results established the prospective of eugenyl acetate against A. baumannii. Copyright © 2016 John Wiley & Sons, Ltd.
Do subjective memory complaints predict falls, fractures and healthcare utilization? A two‐year prospective study based on a cohort of older women recruited from primary care
Authors: Al‐Sari Usama A. , Tobias Jon H. , Archer Hilary , Clark Emma M. 
Published: July 2016

ObjectiveA proportion of older individuals report subjective memory complaints (SMCs), which can predict the development of cognitive impairment and dementia. Previous studies based on secondary care suggest that SMC is also associated with other adverse health consequences, including falls, fractures and increased healthcare utilization. In this study, we aimed to establish whether similar findings are observed in the wider population.MethodsProspective analysis of the Cohort for Skeletal Health in Bristol and Avon, a population‐based cohort recruited from primary care, was carried out. Data were collected by self‐completion questionnaire at baseline and 2 years. SMC was assessed at baseline. Fractures, measures of falls, mobility and healthcare utilization were assessed 2 years later. A random 5% subsample of data was validated against electronic general practitioner records. Logistic regression was used to identify independent associations, following adjustment for a range of confounders assessed at baseline.ResultsData were available on 3184 women. Three hundred and fifty participants (11.0%) reported SMC. They were older (73.3 ± 4.5 vs 72.0 ± 4.2 years) and less mobile compared with those not reporting SMC. SMCs at baseline were associated with an increased risk of upper limb fractures over the following 2 years (OR 1.72, 95% CI 1.02–2.90). SMCs were also associated with an increased risk of falls (OR 1.83, 95% CI 1.41–2.38) and increased healthcare utilization (OR for hospital appointments 2.20, 95% CI 1.26–3.86). No association was observed with bone mineral density at any site.ConclusionsSubjective memory complaints are important markers of adverse health outcomes and should prompt interventions to reduce fractures such as physiotherapy‐led fall reduction programmes. Copyright © 2016 John Wiley & Sons, Ltd.
Can we translate the UK automation experience?
Authors: Marotti Richard 
Published: July 2016

AbstractAutomated dispensing systems (ADS) have the potential to reduce certain types of medication errors and improve the overall efficiency of pharmacy operations. Uptake of this technology in Australia has been limited to date with limited Australian reviews completed assessing the benefits from medication safety, time and cost‐savings perspectives. The purpose of this preceptorship was to evaluate the United Kingdom (UK) experience and determine which understandings could be translated to the Australian setting.