bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does an earthworm species acclimatize and/or adapt to soil calcium conditions? The consequences of soil nitrogen mineralization in forest soil
Authors: Kawakami Tomoya , Makoto Kobayashi 
Published: May 2017

AbstractCalcium (Ca)‐rich food can increase feeding of Lumbricidae. Earthworms can be genetically differentiated at a small spatial scale and acclimatize to the local environment during growth. Soil feeding and subsequent cast production by earthworms affects soil N mineralization. Here, we hypothesized that soil feeding and subsequent cast production by Lumbricidae species increases with high soil Ca content and that this increase is stronger in worms from high‐Ca soil. We also hypothesized that changes in the soil feeding of Lumbricidae species along with the Ca content affects the soil N mineralization via changes in the cast production. Using a geophageous earthworm species (Eisenia japonica) originated from two different Ca environments (calcareous soil and sedimentary soil), we investigated cast production and soil N mineralization in three soils (sedimentary soil, sedimentary soil with Ca addition, and calcareous soil). The soil feeding of E. japonica from both origins did not always increase despite the high soil Ca content. We suggest that both the Ca content and other soil conditions (e.g., soil C:N) might be major factors in increasing soil feeding by E. japonica. Furthermore, the influence of Ca addition on cast production varied according to the earthworm origin. As expected, these differences in cast production are linked to soil N mineralization (especially nitrification). In summary, our study suggests that the acclimatization and/or adaptation of Lumbricidae species to local environmental factors not only soil Ca content explains spatially heterogeneous soil N mineralization in forest soil.
Effect of Different Frying Methods on the Total trans Fatty Acid Content and Oxidative Stability of Oils
Authors: Baltacıoğlu Cem 
Published: May 2017

AbstractThe main objective of this study was to determine the effect of different frying oils and frying methods on the formation of trans fatty acids and the oxidative stability of oils. Sunflower, canola and commercial frying oils, the most commonly used oils for frying potatoes in the fast food industry, were used as the frying medium. The value for total polar compounds was highest when commercial frying oil was used in the microwave oven (22.5 ± 1.1). The peroxide value, as an indicator of oil oxidation, was lowest for microwave oven frying (2.53 ± 0.03). The K232 and K270 values were 0.41 ± 0.04 and 0.18 ± 0.02, respectively, for commercial frying oil in the microwave oven. The lowest free fatty acid content was recorded for the commercial frying oil used in the deep‐fat fryer at 190 °C. The highest iodine value was measured for sunflower oil used in the deep‐fat fryer (148.14 ± 0.07), indicating a greater degree of unsaturation. The lowest trans fatty acid value was recorded for sunflower oil in the microwave oven (0.17 ± 0.05), with a higher overall amount of total trans fatty acids observed for oils after frying in the electrical deep‐fat fryer compared to the microwave. Sunflower oil was favourable for both frying methods in terms of the trans fatty acid content.
Bactericidal potential of silver nanoparticles synthesized using cell-free extract of Comamonas acidovorans: in vitro and in silico approaches
Authors: Rudakiya Darshan M. , Pawar Kirti 
Published: May 2017

Abstract
The need to overcome human threats from pathogenic microbes, development of nanomaterials have been provoked for a new generation of antimicrobials. In the present study, biosynthesis of silver nanoparticles (AgNPs) was acquired using Comamonas acidovorans extract within 72 h under static condition. Electron microscopy studies revealed that the size of AgNPs was ranging from 6–53 nm and had spherical, oval and irregular shapes with smooth surfaces. Prepared AgNPs interacted with proteins, carbohydrates and other aromatic molecules. Biosynthesized AgNPs were bactericidal, which significantly inhibited pathogenic microbes, i.e., Streptococcus pyogenes, Staphylococcus aureus and Escherichia coli. Higher concentrations of AgNPs (20 μg ml−1) inhibited 92–98% growth of all tested bacteria within 24 h. AgNPs–protein network studies carried out to recognize the protein interactions with AgNPs and to understand probable bactericidal mechanisms. AgNPs may penetrate into cell through membrane proteins and damage them by modifying amino acids. Due to AgNPs–protein interactions, dysfunctions in enzymes obstruct certain metabolic processes, which cause the bacteria to die eventually. In certain pathogenic microbes, cue and cus systems detoxify Ag+ ions, transport through transporter proteins and expel them to the extracellular space, which are mainly responsible for Ag resistance.
Accuracy of Children's Perioperative Memories
Authors: Hackmann Thomas , Haworth Rebecca A. , Hong Paul , Gillespie Joanne , Chorney Jill 
Published: May 2017

AbstractChildren's declarative memories of medical procedures can influence their responses to subsequent events. No previous study has examined the accuracy of children's declarative memories after surgery. We tested the memory of 34 anesthesia‐naïve five‐ to nine‐year‐old children undergoing ambulatory surgery for accuracy of contextual details, pain, and fear two weeks postoperatively. Parents were not present during induction, and we did not use sedative premedication. Children had a mean contextual recall accuracy of 64.5%. Most children (60.6%) remembered a prompt that was given one minute after receiving nitrous oxide. Children's memories of pain and fear were similar to their reported pain and fear on the day of surgery. Of 29 children, 6 (20.7%) exaggerated their memory of fear, and 8 of 22 children (36.4%) exaggerated their memory of pain. Although a small proportion of children had exaggerated memories, there was no evidence of consistent bias in their memory of fear or pain.
Seabird mortality in the Namibian demersal longline fishery and recommendations for best practice mitigation measures
Authors: Paterson John R. B. , Yates Oliver , Holtzhausen Hannes , Reid Tim , Shimooshili Kaspar , Yates Sarah , Sullivan Benedict J. , Wanless Ross M. 
Published: May 2017

AbstractSeabird bycatch is widely regarded as the greatest threat globally to procellariiform seabirds. Although measures to reduce seabird–fishery interactions have been in existence for many years, uptake in fleets with high risk profiles remains variable. We recorded seabird bycatch and other interactions in the Namibian demersal longline fishery. Interaction rates were estimated for seasonal and spatial strata and scaled up to fishing effort data. Bycatch rates were 0.77 (95% CI 0.24–1.39) and 0.37 (95% CI 0.11–0.72) birds per 1,000 hooks in winter and summer, respectively. Scaling up to 2010, the most recent year for which complete data are available, suggests 20,567 (95% CI 6,328–37,935) birds were killed in this fishery that year. We compared bycatch rates to those from experimental fishing sets using mitigation measures (one or two bird-scaring lines and the replacement of standard concrete weights with 5 kg steel weights). All mitigation measures significantly reduced the bycatch rate. This study confirms the Namibian longline fishery has some of the highest known impacts on seabirds globally, but implementing simple measures could rapidly reduce those impacts. In November 2015 the Ministry of Fisheries and Marine Resources introduced regulations requiring the use of bird-scaring lines, line weighting and night setting in this fishery. A collaborative approach between NGOs, industry and government was important in achieving wide understanding and acceptance of the proposed mitigation measures in the lead up to the introduction of new fishery regulations.
Cerebral dopamine deficiency, plasma monoamine alterations and neurocognitive deficits in adults with phenylketonuria
Authors: Boot E. , Hollak C. E. M. , Huijbregts S. C. J. , Jahja R. , van Vliet D. , Nederveen A. J. , Nieman D. H. , Bosch A. M. , Bour L. J. , Bakermans A. J. , Abeling N. G. G. M. , Bassett A. S. , van Amelsvoort T. A. M. J. , van Spronsen F. J. , Booij J. 
Published: May 2017

BackgroundPhenylketonuria (PKU), a genetic metabolic disorder that is characterized by the inability to convert phenylalanine to tyrosine, leads to severe intellectual disability and other cerebral complications if left untreated. Dietary treatment, initiated soon after birth, prevents most brain-related complications. A leading hypothesis postulates that a shortage of brain monoamines may be associated with neurocognitive deficits that are observable even in early-treated PKU. However, there is a paucity of evidence as yet for this hypothesis.MethodsWe therefore assessedin vivostriatal dopamine D2/3receptor (D2/3R) availability and plasma monoamine metabolite levels together with measures of impulsivity and executive functioning in 18 adults with PKU and average intellect (31.2 ± 7.4 years, nine females), most of whom were early and continuously treated. Comparison data from 12 healthy controls that did not differ in gender and age were available.ResultsMean D2/3R availability was significantly higher (13%;p= 0.032) in the PKU group (n= 15) than in the controls, which may reflect reduced synaptic brain dopamine levels in PKU. The PKU group had lower plasma levels of homovanillic acid (p< 0.001) and 3-methoxy-4-hydroxy-phenylglycol (p< 0.0001), the predominant metabolites of dopamine and norepinephrine, respectively. Self-reported impulsivity levels were significantly higher in the PKU group compared with healthy controls (p= 0.033). Within the PKU group, D2/3R availability showed a positive correlation with both impulsivity (r= 0.72,p= 0.003) and the error rate during a cognitive flexibility task (r= 0.59,p= 0.020).ConclusionsThese findings provide further support for the hypothesis that executive functioning deficits in treated adult PKU may be associated with cerebral dopamine deficiency.
He said, she said: effects of bilingualism on cross-talker word recognition in infancy
Authors: SINGH LEHER 
Published: May 2017

AbstractThe purpose of the current study was to examine effects of bilingual language input on infant word segmentation and on talker generalization. In the present study, monolingually and bilingually exposed infants were compared on their abilities to recognize familiarized words in speech and to maintain generalizable representations of familiarized words. Words were first presented in the context of sentences to infants and then presented to infants in isolation during a test phase. During test, words were produced by a talker of the same gender and by a talker of the opposite gender. Results demonstrated that both bilingual and monolingual infants were able to recognize familiarized words to a comparable degree. Moreover, both bilingual and monolingual infants recognized words in spite of talker variation. Results demonstrated robust word recognition and talker generalization in monolingual and bilingual infants at 8 months of age.
EQUAL CULPABILITY AND THE SCOPE OF THE WILLFUL IGNORANCE DOCTRINE
Authors: Sarch Alexander 
Published: May 2017

ABSTRACTCourts commonly allow willful ignorance to satisfy the knowledge element of a crime. The traditional rationale for this doctrine is that willfully ignorant misconduct is just as culpable as knowing misconduct. But it is not obvious that this “equal culpability thesis” holds across the board. Is it true in all cases of willful ignorance or only some? This is the question I investigate here.Specifically, I argue against several common versions of the equal culpability thesis before defending my own restricted version. First, I argue that the broadest version of the thesis, adopted by many courts, is overinclusive. Then I argue against several restricted versions of the thesis offered by legal theorists including Doug Husak, David Luban, and Deborah Hellman. My own account, by contrast, is premised on a duty of reasonable investigation. If my account is on the right track, the widely employed willful ignorance doctrine stands in need of reform.
Aroma-Home’s edible stories: An urban community garden performs
Authors: Haedicke Susan 
Published: May 2017

AbstractAroma-Home, an artist-initiated community garden in Villetaneuse, just outside Paris, France, originated as a way to poeticize damaged urban locations by creating small communally-created pockets of unexpected natural beauty. In 2013, Sarah Harper of Friches Théâtre Urbain joined forces with local inhabitants to reclaim public spaces marred by construction and neglect. Together, they began to alter the urban landscape with whimsical plant-based interventions that sprouted up behind construction fences. This guerrilla gardening soon led to the sowing of a community garden that wove together food-growing, story-telling and place-making and fashioned its particular identity through cultural practices around growing, preparing and sharing food of the multi-ethnic participants. The horticultural-culinary conversations became inextricably connected to gardening activities: edible stories involving food memories and horticultural skills that nourished those who prepared and consumed them. This ‘From the Field’ paper looks at how the community garden/art-making processes of Aroma-Home transformed a bleak construction site into a mini-urban agricultural ‘commons’ where imagining, planting and harvesting the garden and its edible stories were all shared.
UkrVO Astroinformatics Software and Web-services
Authors: Vavilova I. B. , Yatskiv Ya. S. , Pakuliak L. K. , Andronov I. L. , Andruk V. M. , Protsyuk Yu. I. , Savanevych V. E. , Savchenko D. O. , Savchenko V. S. 
Published: May 2017

AbstractThe aim of this paper is to introduce the software and astronomical web-services developed in frame of the Ukraine Virtual Observatory (UkrVO) and VIrtual Roentgen and Gamma Observatory (VIRGO) to the broad astronomical community. We report briefly on such web-services as the public databases “Sky Maps” of X-ray observations by XMM-Newton, the Earth Orbital Parameters for International Earth Rotation System, and the UkrVO Joint Digitized Archive of astroplates. We refer to such software as the “Multi-Column View”, “Variable Stars Calculator”, “FrameSmooth” for variable star’s research and “Collection Light Technology” (CoLiTec) software for search and discovery of new Solar System bodies.
Secondary Level Achievement
Authors: McIlroy David , Palmer-Conn Sue , Lawler Bridget , Poole Karen , Faruk Ursavas Ömer 
Published: May 2017

Abstract. The study was developed in the context of Personality and Social Cognitive Theory with constructs that encapsulate non-intellective processes of academic achievement. The goal was to explore the role of the Five Factor Model (FFM) of personality in academic performance and to use this model as a reference point to test the incremental validity of two measures of Self-efficacy (Academic and Emotional) and an indicator of Absenteeism. Participants (N = 120) were comprised of 17-year-old male (n = 47) and female (n = 73) opportunistically sampled secondary level college students. A cross-sectional design was used to examine the relationship between the independent variables (FFM, Academic Self-efficacy, Emotional Self-efficacy, and Absenteeism) and the outcome variable, Grade Points Average (GPA). Correlation analysis found that four FFM factors and the two Self-efficacy measures were associated with GPA. In a hierarchical regression analysis, the FFM explained 22% variance on performance and the two Self-efficacy measures added 9% incremental variance followed by 3% for Absenteeism. Overall, the non-intellective constructs explain a substantial 34% variance on achievement and provide focal points for theoretical, empirical, and pedagogical evaluation. Moreover, they are suggestive of the pathways and processes that support learning, augment ability, and enhance achievement.
Cell-free chromatin from dying cancer cells integrate into genomes of bystander healthy cells to induce DNA damage and inflammation
Authors: Mittra Indraneel , Samant Urmila , Sharma Suvarna , Raghuram Gorantla V , Saha Tannistha , Tidke Pritishkumar , Pancholi Namrata , Gupta Deepika , Prasannan Preeti , Gaikwad Ashwini , Gardi Nilesh , Chaubal Rohan , Upadhyay Pawan , Pal Kavita , Rane Bhagyeshri , Shaikh Alfina , Salunkhe Sameer , Dutt Shilpee , Mishra Pradyumna K , Khare Naveen K , Nair Naveen K , Dutt Amit 
Published: May 2017

AbstractBystander cells of the tumor microenvironment show evidence of DNA damage and inflammation that can lead to their oncogenic transformation. Mediator(s) of cell–cell communication that brings about these pro-oncogenic pathologies has not been identified. We show here that cell-free chromatin (cfCh) released from dying cancer cells are the key mediators that trigger both DNA damage and inflammation in the surrounding healthy cells. When dying human cancer cells were cultured along with NIH3T3 mouse fibroblast cells, numerous cfCh emerged from them and rapidly entered into nuclei of bystander NIH3T3 cells to integrate into their genomes. This led to activation of H2AX and inflammatory cytokines NFκB, IL-6, TNFα and IFNγ. Genomic integration of cfCh triggered global deregulation of transcription and upregulation of pathways related to phagocytosis, DNA damage and inflammation. None of these activities were observed when living cancer cells were co-cultivated with NIH3T3 cells. However, upon intravenous injection into mice, both dead and live cells were found to be active. Living cancer cells are known to undergo extensive cell death when injected intravenously, and we observed that cfCh emerging from both types of cells integrated into genomes of cells of distant organs and induced DNA damage and inflammation. γH2AX and NFκB were frequently co-expressed in the same cells suggesting that DNA damage and inflammation are closely linked pathologies. As concurrent DNA damage and inflammation is a potent stimulus for oncogenic transformation, our results suggest that cfCh from dying cancer cells can transform cells of the microenvironment both locally and in distant organs providing a novel mechanism of tumor invasion and metastasis. The afore-described pro-oncogenic pathologies could be abrogated by concurrent treatment with chromatin neutralizing/degrading agents suggesting therapeutic possibilities.
Interactive models of communication at the nanoscale using nanoparticles that talk to one another
Authors: Llopis-Lorente Antoni , Díez Paula , Sánchez Alfredo , Marcos María D. , Sancenón Félix , Martínez-Ruiz Paloma , Villalonga Reynaldo , Martínez-Máñez Ramón 
Published: May 2017

Abstract‘Communication’ between abiotic nanoscale chemical systems is an almost-unexplored field with enormous potential. Here we show the design and preparation of a chemical communication system based on enzyme-powered Janus nanoparticles, which mimics an interactive model of communication. Cargo delivery from one nanoparticle is governed by the biunivocal communication with another nanoparticle, which involves two enzymatic processes and the interchange of chemical messengers. The conceptual idea of establishing communication between nanodevices opens the opportunity to develop complex nanoscale systems capable of sharing information and cooperating.
JunB is essential for IL-23-dependent pathogenicity of Th17 cells
Authors: Hasan Zafrul , Koizumi Shin-ichi , Sasaki Daiki , Yamada Hayato , Arakaki Nana , Fujihara Yoshitaka , Okitsu Shiho , Shirahata Hiroki , Ishikawa Hiroki 
Published: May 2017

AbstractCD4+T-helper cells producing interleukin-17 (IL-17), known as T-helper 17 (TH17) cells, comprise heterogeneous subsets that exhibit distinct pathogenicity. Although pathogenic and non-pathogenic TH17 subsets share a common RORγt-dependent TH17 transcriptional programme, transcriptional regulatory mechanisms specific to each of these subsets are mostly unknown. Here we show that the AP-1 transcription factor JunB is critical for TH17 pathogenicity. JunB, which is induced by IL-6, is essential for expression of RORγt and IL-23 receptor by facilitating DNA binding of BATF at theRorclocus in IL-23-dependent pathogenic TH17 cells, but not in TGF-β1-dependent non-pathogenic TH17 cells.Junb-deficient T cells fail to induce TH17-mediated autoimmune encephalomyelitis and colitis. However, JunB deficiency does not affect the abundance of gut-resident non-pathogenic TH17 cells. The selective requirement of JunB for IL-23-dependent TH17 pathogenicity suggests that the JunB-dependent pathway may be a therapeutic target for autoimmune diseases.
An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial
Authors: DeZure Adam D. , Coates Emily E. , Hu Zonghui , Yamshchikov Galina V. , Zephir Kathryn L. , Enama Mary E. , Plummer Sarah H. , Gordon Ingelise J. , Kaltovich Florence , Andrews Sarah , McDermott Adrian , Crank Michelle C. , Koup Richard A , Schwartz Richard M. , Bailer Robert T. , Sun Xiangjie , Mascola John R. , Tumpey Terrence M. , Graham Barney S. , Ledgerwood Julie E. 
Published: May 2017

AbstractA novel avian influenza subtype, A/H7N9, emerged in 2013 and represents a public health threat with pandemic potential. We have previously shown that DNA vaccine priming increases the magnitude and quality of antibody responses to H5N1 monovalent inactivated boost. We now report the safety and immunogenicity of a H7 DNA-H7N9 monovalent inactivated vaccine prime-boost regimen. In this Phase 1, open label, randomized clinical trial, we evaluated three H7N9 vaccination regimens in healthy adults, with a prime-boost interval of 16 weeks. Group 1 received H7 DNA vaccine prime and H7N9 monovalent inactivated vaccine boost. Group 2 received H7 DNA and H7N9 monovalent inactivated vaccine as a prime and H7N9 monovalent inactivated vaccine as a boost. Group 3 received H7N9 monovalent inactivated vaccine in a homologous prime-boost regimen. Overall, 30 individuals between 20 to 60 years old enrolled and 28 completed both vaccinations. All injections were well tolerated with no serious adverse events. 2 weeks post-boost, 50% of Group 1 and 33% of Group 2 achieved a HAI titer ≥1:40 compared with 11% of Group 3. Also, at least a fourfold increase in neutralizing antibody responses was seen in 90% of Group 1, 100% of Group 2, and 78% of Group 3 subjects. Peak neutralizing antibody geometric mean titers were significantly greater for Group 1 (GMT = 440.61, p < 0.05) and Group 2 (GMT = 331, p = 0.02) when compared with Group 3 (GMT = 86.11). A novel H7 DNA vaccine was safe, well-tolerated, and immunogenic when boosted with H7N9 monovalent inactivated vaccine, while priming for higher HAI and neutralizing antibody titers than H7N9 monovalent inactivated vaccine alone.
Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver
Authors: Fujisawa Koichi , Takami Taro , Matsuzaki Aya , Matsumoto Toshihiko , Yamamoto Naoki , Terai Shuji , Sakaida Isao 
Published: May 2017

AbstractLifestyle-related diseases have become a major issue in recent years. The increasing incidence of fatty liver underlines the urgency with which the issues of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) need to be addressed. L-carnitine is a compound known to transport fatty acids into the mitochondria to enhance β-oxidation-mediated metabolism of fats. In this study, the effects of L-carnitine administration on fatty liver of medaka (Oryzias latipes) were analysed, to check for disease improvement and metabolic changes. Additionally, the effects of the concomitant administration of L-carnitine and eicosapentaenoic acid (20:5n-3) (EPA) were investigated. Findings indicated reduced lipid deposition, increase in metabolites associated with β-oxidation, and significant reduction in fatty acid levels in the liver, implying improvement in fatty liver condition. Concomitant administration of L-carnitine and EPA resulted in further benefits, via changes in fatty acid composition in the medaka fatty liver model.