bluuebunny/crossref_metadata_2025_split huggingface dataset:
Constructing a novel prognostic model of gastric cancer related to mitochondrial membrane permeability change-driven necrosis based on single cell and bulk transcriptome
Authors: Gan Xinli , Cheng Huaifu , Ma Ning , Wang Zhonglin , Mao Zhongqi 
Published: October 2024

Abstract

Background Gastric cancer (GC) is the fifth most common cancer in the world, with a late diagnosis and poor prognosis. The mitochondrial permeability transition-driven necrosis (MPTDN) is often associated with cancer, while its mechanism in GC is unclear.Methods A single-cell RNA sequencing (scRNA-seq) dataset GSE183904, and two mRNA profile datasets TCGA-stomach adenocarcinoma (STAD) and GSE62254 were downloaded from the online databases. After a series of analyses of GSE183904, the differentially expressed genes (DEGs) in different proportions of cells (DCs) were selected between GC and controls for further analysis, namely DC-DEGs. The DEGs between STAD and normal controls (STAD-DEGs) were screened, and then highly correlated modules with MPTDN-related genes (MPTDN-RGs) were obtained by Weighted gene co-expression network analysis (WGCNA). Next, DC-DEGs, STAD-DEGs, and module genes were overlapped as candidate genes. The prognostic genes were selected via the Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression model, and the prognostic risk model was constructed and verified. Then, the immune cell infiltrations and Immunotherapy response were conducted. Later, pseudotime analyses were performed to explore key cell evolution trajectories. Furthermore, the clinic specimens were collected to perform qPCR analysis.Results Epithelial cells and Tissue stem cells were obtained as DCs, and 1,592 DC-DEGs were identified between GC and normal controls. After the overlapping of 2,238 STAD-DEGs, 1,592 DC-DEGs, and 3,832 module genes, a total of 112 candidate genes were determined. Then, 4 prognostic genes (GPX3, CD36, VCAN, and SERPINE1) were identified the risk model was constructed on this basis. Afterward, risk score, age, and N categories were screened as the independent prognostic factors to construct a nomogram model, which could effectively predict the 1-, 3-, and 5-year OS of STAD patients. Subsequently, Endothelial cells and Tissue stem cells differentiated in normal control were less than those of GC. Finally, Moreover, the qPCR revealed that the expression of GPX3 and CD36 was reduced in GC tumor tissues.Conclusion Overall GPX3, CD36, VCAN, and SERPINE1 could be potential therapeutic targets to diagnose and treat GC. Tissue stem cells were key cells in GC patients and provided strong support for further understanding of GC.
3-D Reconstruction Framework for Tree Roots based on Permittivity Inversion and Feature-Matching Interpolation
Authors: Lv Shenghua , Zhang Xiaowei , Zhao Xuan , Zhou Boyang , Lin Chen , Wen Jian 
Published: October 2024

Abstract

Background and Aims The structure of tree root systems is crucial for their growth, health, and stability. However, traditional methods for detecting root systems commonly face challenges such as computational complexity, low precision, and inadequate imaging visualization. This study proposes a method for the 3-D reconstruction of tree root systems, utilizing ground-penetrating radar (GPR) data coupled with deep learning-based inversion of 2-D permittivity distributions and feature-matching interpolation. Methods Our approach involves the inversion of 2-D permittivity distributions from GPR scan data using deep learning techniques to obtain cross-sectional parameter information of the root systems. We enhance the imaging accuracy of root identification through cluster analysis and threshold segmentation. Furthermore, by integrating target root detection, parameter calculation, and feature-matching interpolation, we reconstruct the 3-D structure of the root systems. Results In the test of simulated data, the method proposed in this paper shows smooth results in interpolation reconstruction and matches the actual values to a high degree. In the validation of actual data, FMIR successfully reconstructed the 3D dielectric constant model of the tree root system with larger diameters in the four main regions, and the reconstructed tree root system was in good agreement with the actual excavated root system. Conclusion The effectiveness and accuracy of this method in reconstructing 3-D permittivity models of tree root systems are validated through simulated and actual testing data experiments. It offers new possibilities for research and applications in root structure analysis.
Identification of groundwater Potential Areas Using GIS and MCDM in arid and Semi-Arid Regions (Case Study: Nayband in Iran)
Authors: Faizabad Amir Khazai- , Pourreza-Bilondi Mohsen , Mohajeri Shahrooz , Besalatpour Aliasghar 
Published: October 2024

Abstract

Groundwater is an important and essential resource in dry and semi-arid regions, as well as in areas with restricted access to surface waters. Global water demand has increased significantly in recent years, largely due to industrial growth, population growth, and shifts in lifestyle and consumption habits. At present, groundwater is a primary source of freshwater, making up around 34% of the total annual global water supply. Water harvesting is a critical and essential part in infrastructure and economic projects, requiring significant investment. Therefore, it is vital to assess this issue for the sustainable management of groundwater systems. Since groundwater operates dynamically, it is essential to employ Geographic Information System (GIS) in the development and management of groundwater. Multi-Criteria Decision Making (MCDM) analysis including commonly used types such as AHP, is an effective technique in this regard. The main objective of this study is to locate potential groundwater areas in Nayband Plain, Tabas County, using GIS and multi-criteria decision-making analysis. The fuzzy-AHP method was employed to create the groundwater potential map. Various features such as slope, geomorphology, soil characteristics, lineaments, land cover type, precipitation and river distance were used to generate the groundwater potential map. Pairwise comparison of criteria and expert opinions were utilized to assign scores and weights to each groundwater potential criterion. Subsequently, the criteria were categorized, and weights were assigned to each category. Using these weights, final maps were generated using ArcMap 10.8 software. The level of groundwater access in the region was qualitatively classified into five categories: very good, good, moderate, poor, and very poor. To validate the generated map, data from 10 wells, 3 qanats, and 4 springs in the Nayband region were utilized. In conclusion, the comparison of the final map with the distribution of wells, springs, and qanats indicates that this method exhibits high accuracy in this area and contributes to the analysis of the groundwater potential of the region.
The relationship between disease perception, self-efficacy, coping style and self-regulatory fatigue in old adults patients with hypertension:A cross-sectional study
Authors: Lu Tingting , Zhang Jianfang , Feng Qi , Teng Jinfeng , Yan Weian 
Published: October 2024

Abstract

Purpose:The old adults patients with hypertension need long-term self-control to maintain their blood pressure levels and delay the development of the disease. In the long run, the patient's self-control ability will be worn down, resulting in self-regulatory fatigue.However, no studies have shown the relationship between disease perception, self-efficacy,coping style, and self-regulatory fatigue.This study aimed to investigate the relationship between disease perception, self-efficacy,coping style and self-regulatory fatigue in old adults patients with hypertension.
Methods:A cross-sectional survey was conducted among 416 old adults patients with hypertension in the First Affiliated Hospital of Jinzhou Medical University, Liaoning Province by convenience sampling method.The general demographic questionnaire, brief illness perception questionnaire,general self-efficacy scale,medical coping modes questionnaire and self-regulatory fatigue scale were used to investigate.The mediation effect was analyzed by Amos23.0 software.
Results:Disease perception, avoidance, and acceptance-resignation can directly act positively on self-regulatory fatigue, while self-efficacy and confrontation can directly act negatively on self-regulatory fatigue. Disease perception can act on self-regulatory fatigue through the chain mediating effect between self-efficacy, confrontation, avoidance, and acceptance-resignation.
Conclusion:The old adults patients with hypertension had higher self-regulatoryfatigue level.Disease perception, avoidance and acceptance-resignation were positively correlated with self-regulatory fatigue, reducing patients' negative emotions about disease and improving their confidence in disease treatment can reduce patients' self-regulatory fatigue.
Short-Term Outcomes of Improving Hydrostatic Pressures on Reducing Intussusception in Children
Authors: Wang Bingjie , Jian Ziwei , Huang Weicheng , Huang Beilei , Ye Fengguang , Chen Jinrong 
Published: October 2024

Abstract

Purpose
The aim of this study is to analyze the effect of increasing enema pressure on enema outcomes.
Methods
We conducted a retrospective study to compare the effect of increasing enema pressure on enema outcomes. The primary outcome was the success rate of reduction, while secondary outcomes included intestinal perforation and recurrence rate.
Results
From May 2017 to April 2021, a total of 531 intussusceptions in 499 patients (Group A 247 patients, Group B 252 patients) were collected. The overall success reduction rate was 97.00%. The success reduction rate in Group A was 99.20% (245/247) and 94.8% (239/252) in Group B (P = 0.004). The overall recurrence rate within 48 hours after the initial enema reduction was 8.02%, and beyond 48 hours was 6.41%. The recurrence rates within 48 hours and beyond 48 hours were 9.39% and 6.53% in group A and 7.11% and 6.69% in group B, respectively (P = 0.526). No complications were associated with the enema reduction procedure.
Conclusion
Our study has shown that using a hydrostatic pressure of 130 mmHg for enema reduction is both effective and safe, with a higher success rate and no increased risk of complications.
Study type:
Retrospective cohort study
Level of evidence:
Therapeutic study, III
Comparison of Factors and Effects of Repeated vs. Acute Ischemic Preconditioning on Enhancing Athletic Performance: A Systematic Review and Meta-Analysis
Authors: Chen Long , He Zhanyang , Zheng Zhe , Pan Huiju , Zhu Houwei 
Published: October 2024

Abstract

Background Repeated ischemic preconditioning (RIPC) has been shown to significantly improve endothelial function, but its effect on enhancing athletic performance remains highly controversial. On the other hand, acute ischemic preconditioning (AIPC) has already been proven to enhance athletic performance. Similar to AIPC, factors such as exercise modality, dosage, training status, and timing of testing are crucial influences on the final effects of RIPC, yet related studies exhibit considerable disagreement. Moreover, the comparison between the effects of repeated ischemic preconditioning and acute ischemic preconditioning has yet to be further clarified.
Objective The primary aim of this meta-analysis is to investigate whether RIPC truly enhances athletic performance while considering exercise modality, dosage, the training status of the tested population, and the timing of observation. It also seeks to compare the effects of RIPC and AIPC on enhancing athletic performance.
Methods A literature search was conducted in five databases. For each outcome, standard error and mean difference or standardized mean difference were calculated. A random-effects model (SMD) with a 95% confidence interval (CI) was used, and analysis was performed using the inverse variance statistical method. The risk of bias was assessed using ROB2 and considerations for randomized controlled trials.
Results RIPC had a small beneficial effect on athletic performance (p = 0.02; SMD = 0.33; 95% CI 0.06–0.60). Regarding exercise modality, RIPC had a small beneficial effect on anaerobic exercise (p = 0.05; SMD = 0.48; 95% CI 0.00–0.97), but no improvement for aerobic exercise (p = 0.12; SMD = 0.26; 95% CI -0.07–0.59). A dosage of RIPC lasting one week or longer was effective (p = 0.006; SMD = 0.37; 95% CI 0.01–0.75). The time interval between RIPC and the start of exercise did not affect the benefit (p > 0.05). RIPC had a greater impact on enhancing athletic performance in the general population (p = 0.06; SMD = 0.36; 95% CI -0.01–0.73; p = 0.001; SMD = 1.03; 95% CI 0.41–1.65) compared to athletes (p > 0.05). The benefit of RIPC compared to AIPC remains unclear (p = 0.1; SMD = 0.22; 95% CI -0.05–0.49).
Conclusion RIPC can effectively improve anaerobic exercise performance and is influenced by RIPC dosage and the training level of the subjects. RIPC dosage lasting one week or longer is most effective in untrained populations and can be observed at any time. However, there are certain limitations in current research, such as the small number of studies available for analysis, and there is insufficient evidence to determine whether repeated or acute IPC application is more effective. Further research is needed to supplement these findings.
PROSPERO registration number CRD42024579390
Hyperkalemia of 10.1 mmol/L without Electrocardiographic Abnormalities in a Patient with Rhabdomyolysis: A Case Report
Authors: Mendoza-Razo Luis Eduardo , Domínguez-López José Alberto , Díaz-Sánchez Bryan Omar 
Published: October 2024

Abstract

Introduction
Hyperkalemia is a life-threatening condition that can lead to electrocardiographic changes and cardiac arrest; to prevent and treat hyperkalemia, it is necessary to understand the underlying causes and correctly interpret the symptoms. The four most common causes of hyperkalemia are renal dysfunction, drugs that alter potassium secretion in the distal tubule, high dietary intake of potassium and increased potassium release from cells; on trauma patients the rhabdomyolysis is a leading cause of hyperkalemia.
Case presentation
This case involves a 36-year-old male patient who suffered severe trauma from a high-speed vehicle accident, resulting in multiple injuries and a Glasgow Coma Scale score of 3/15. Initial assessment revealed critical airway compromise and significant hemodynamic instability. Laboratory tests indicated extreme hyperkalemia with a serum potassium level of 10.1 mmol/L and elevated creatine kinase (CK) levels, leading to a diagnosis of rhabdomyolysis. Notably, the patient exhibited no electrocardiographic changes typically associated with hyperkalemia. Emergency interventions included intubation, fluid resuscitation, and urgent hemodialysis, which successfully normalized potassium and CK levels over time.
Conclusions
This report emphasizes the importance of prompt recognition and management of hyperkalemia in trauma patients, highlighting a multidisciplinary approach to prevent severe complications and improve patient outcomes.
Anti-radar based on metasurface
Authors: Cui Tie Jun , Sun Zongzheng , Zhang Lei , Chen Xiao Qing , Xu Hong , Xiao Guoyao , Zheng Yi Ning , Wu Yaojun , Liu Zhixing , Fu Haosheng , Zhou Xiaoyang , Chen Zhanye , Chen Hui , Quan Yinghui 
Published: October 2024

Abstract

In advanced multi-static radar (MSR), multidimensional information from target’s echo signals is gathered by multiple receivers to achieve precise target position by using diverse localization algorithms. Owing to its efficient target localization and tracking capability, MSR has found wide applications in transportation, military, aviation and aerospace. The multi-static nature of MSR also makes it difficult for countering. Here, we propose an anti-radar methodology based on space-time-coding metasurface (STCM) for countering MSR. Affixed to the target to be detected, STCM is modulated to dynamically alter the echo signals received by all receivers. This modulation can simultaneously control the space- and frequency-domain characteristics of the echo signals, thwarting the functionality of MSR. To validate the methodology, we develop a prototype of STCM-based anti-MSR system and successfully demonstrate its capability to neutralize various MSR technologies. The proposed method is expected to find applications in anti-MSR to avoid the target detection in scenarios requiring facility concealment, military operations, and security protection.
PGLYRP-1 mediated intracellular peptidoglycan detection promotes mucosal protection
Authors: Reinecker Hans-Christian , Chen Shuyuan , Putnik Rachel , Li Xi , Diwaker Alka , Vasconcelos Marina , Liu Shuzhen , Zhou Junhui , Guo Lei , Xu Lin , Temme J. Sebastian , Bersch Klare , Hyland Stephen , Yin Jianyi , Burstein Ezra , Gildersleeve Jeffrey , Grimes Catherine 
Published: October 2024

Abstract

Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are implicated in the control of the intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and receptor signaling mechanisms remain poorly understood. We identified PGLYRP-1 as a receptor for the disaccharide motif of lysine N-acetylglucosamine N-acetylmuramic tripeptide (GMTriP-K) with a newly constructed PGN microarray. Surprisingly, PGLYRP-1 was required for innate immune activation of macrophages by GMTriP-K but not N-acetylglucosamine N-acetylmuramic dipeptide (GMDiP) or muramyl dipeptide (MDP). In macrophages, intracellular PGLYRP-1 complexed with NOD2 and GEF-H1, both of which were required for GMTriP-K-regulated gene expression. PGLYRP-1 localized to the endoplasmic reticulum and interacted at the Golgi with NOD2 upon GMTriP-K stimulation. PGLYRP-1 upregulation and its dependent gene expression signatures were induced in both mouse intestinal inflammation and human ulcerative colitis. Importantly, PGLYRP-1 activation by GMTriP-K resulted in innate immune activation and protection of mice from colitis. Our results show that PGLYRPs can function as intracellular PGN pattern recognition receptors for the control of host defense responses in the intestine.
Personalized Tourism Recommendation Model Based on Temporal Multilayer Sequential Neural Network
Authors: Xiao XueFei , Li ChunHua , Wang XingJie , Zeng AnPing 
Published: October 2024

Abstract

Personalized tourism has recently become an increasingly popular mode of travel. Effective personalized route recommendations must consider numerous complex factors, including the vast historical trajectory of tourism, individual traveler preferences, and real-time environmental conditions. However, the large temporal and spatial spans of trajectory data pose significant challenges to achieving high relevance and accuracy in personalized route recommendation systems. This study addresses these challenges by proposing a personalized tourism route recommendation model, the Temporal Multilayer Sequential Neural Network (TMS-Net). TMS-Net mitigates issues related to large temporal spans by introducing a fixed-length trajectory segmentation method. Additionally, it integrates a self-attention mechanism with relative positional information to preserve correlations between travel routes. The multilayer Long Short-Term Memory neural network enhances the ability of the model to identify tourist points of interest, thereby improving the relevance of the recommendations. The TMS-Net model was trained on over six million trajectory data points from Chengdu City, Sichuan Province, spanning January 2016 to December 2022. The experimental results indicated that the optimal trajectory segmentation interval ranged from 0.8–1.2 h. The model achieved a recommendation accuracy of 88.6% and a Haversine distance error of 1.23, demonstrating its ability to accurately identify tourist points of interest and provide highly relevant recommendations. This study demonstrates the potential of TMS-Net to improve personalized tourism experiences significantly and offers new methodological insights for personalized travel recommendations.
WITHDRAWN: Configuration Paths for High-Quality Development of Listed Companies Basedon the TOE Framework: Evidence from China's high- and new-technologyenterprises
Authors: Qian Min , Yang Jiameng 
Published: October 2024

Abstract

In the context of dual-carbon goals, high-quality development has become an inevitable trend for technology enterprises. This study employs a dynamic Qualitative Comparative Analysis (QCA) method, based on the Technology Organization Environment (TOE) framework theory, and a configurational analysis perspective. Using panel data from Chinese listed high- and new-technology enterprises from 2013 to 2022 as the research sample, this study explores the combinatorial paths that drive high-quality development. The research findings are as follows: (1) The antecedent factors for high-quality development exhibit "multiple concurrent" characteristics, and a single condition does not constitute a necessary condition. (2) Based on the five driving paths for high-quality development, three models can be summarized under the synergistic effects of different antecedent conditions: "multi-factor influence type,” "green innovation-led type,” and "digital technology-driven type.” Regardless of the path, R&D investment and enterprise scale are indispensable driving factors. (3) Under specific objective endowment conditions, when enterprise executives possess a high level of green cognition, they can compensate for inadequate digital transformation, market competition, and environmental regulations. Therefore, enterprises need to enhance scale and R&D investment, based on existing endowments, and shift from a single-factor influence concept to a comprehensive selection approach.
New Structure of Step-Up DC-DC Converter Based on Three Winding Coupled Inductor with High Gain Capability Featuring Integrated Renewable Energy Applications
Authors: Aghakhanlou Pouneh , Falahi Fatemeh , Nadermohammadi Ali , Sarikhan Hasan , Hosseini Seyed Hossein , Roostami Naghi , Sabahi Mehran 
Published: October 2024

Abstract

This research presents an innovative design for a non-isolated DC-DC converter, which utilizes a single switch in a high step-up configuration. The key element of this design is a three-winding coupled inductor (TWCI), which plays a crucial role in achieving a substantial voltage increase. By utilizing a low duty cycle, the converter minimizes conduction losses in the power switch, resulting in enhanced efficiency. The converter offers several benefits, including reduced voltage stress on both power switches and diodes, a common ground, high efficiency, a simple structure and control mechanism, and fewer components. The study thoroughly examines the converter's operational modes and provides a comparison with other types of converters to highlight its distinctive characteristics. To validate the converter’s performance, a 400W prototype was developed and tested in the lab, operating with a 20V input, a 260V output, and a switching frequency of 50 kHz.