bluuebunny/crossref_metadata_2025_split huggingface dataset:
Environmentally driven extinction and opportunistic origination explain fern diversification patterns
Authors: Lehtonen Samuli , Silvestro Daniele , Karger Dirk Nikolaus , Scotese Christopher , Tuomisto Hanna , Kessler Michael , Peña Carlos , Wahlberg Niklas , Antonelli Alexandre 
Published: June 2017

AbstractCombining palaeontological and neontological data offers a unique opportunity to investigate the relative roles of biotic and abiotic controls of species diversification, and the importance of origination versus extinction in driving evolutionary dynamics. Ferns comprise a major terrestrial plant radiation with an extensive evolutionary history providing a wealth of modern and fossil data for modelling environmental drivers of diversification. Here we develop a novel Bayesian model to simultaneously estimate correlations between diversification dynamics and multiple environmental trajectories. We estimate the impact of different factors on fern diversification over the past 400 million years by analysing a comprehensive dataset of fossil occurrences and complement these findings by analysing a large molecular phylogeny. We show that origination and extinction rates are governed by fundamentally different processes: originations depend on within-group diversity but are largely unaffected by environmental changes, whereas extinctions are strongly affected by external factors such as climate and geology. Our results indicate that the prime driver of fern diversity dynamics is environmentally driven extinction, with origination being an opportunistic response to diminishing ecospace occupancy.
Znf179 induces differentiation and growth arrest of human primary glioblastoma multiforme in a p53-dependent cell cycle pathway
Authors: Lee Kuen-Haur , Chen Chi-Long , Lee Yi-Chao , Kao Tzu-Jen , Chen Kai-Yun , Fang Chih-Yeu , Chang Wen-Chang , Chiang Yung-Hsaio , Huang Chi-Chen 
Published: June 2017

AbstractMalignant glioblastoma multiforme (GBM) is an aggressive brain tumor with strong local invasive growth and a poor prognosis. One probable way to manipulate GBM cells toward a less invasive status is to reprogram the most malignant GBM cells to a more differentiated and less oncogenic phenotype. Herein, we identified a novel role of a RING finger protein Znf179 in gliomagenesis. Znf179 overexpression induced differentiation of primary GBM cells, which were accompanied with elevated glial fibrillary acidic protein (GFAP) expression through up-regulating several cell-cycle-related factors, p53, p21, and p27, and allowed the cell-cycle arrest in the G0/G1 phase. In addition, Znf179 was highly correlated with the prognosis and survival rates of glioma patients. The expression levels of Znf179 was relatively lower in glioma patients compared to normal people, and glioma patients with lower expression levels of Znf179 mRNA had poorer prognosis and lower survival rates. In conclusion, we provide novel insight that Znf179 can reprogram GBM cells into a more-differentiated phenotype and prevent the progression of gliomas to a more-malignant state through p53-mediated cell-cycle signaling pathways. Understanding the molecular mechanism of Znf179 in gliomagenesis could help predict prognostic consequences, and targeting Znf179 could be a potential biomarker for glioma progression.
Language and False-Belief Task Performance in Children With Autism Spectrum Disorder
Authors: Jeffrey Farrar M. , Seung Hye Kyeung , Lee Hyeonjin 
Published: June 2017

PurposeLanguage is related to false-belief (FB) understanding in both typically developing children and children with autism spectrum disorder (ASD). The current study examined the role of complementation and general language in FB understanding. Of interest was whether language plays similar or different roles in the groups' FB performance.MethodParticipants were 16 typically developing children (mean age = 5.0 years; mental age = 6.7) and 18 with ASD (mean age = 7.3 years; mental age = 8.3). Children were administered FB and language tasks (say- andthink-complements), receptive and expressive vocabulary tests, and relative clauses.ResultsWhen mental age and receptive and expressive vocabulary were used as separate covariates, the typical control group outperformed the children with ASD in FB task performance. Chi-square analyses indicated that passing both complementation tasks was linked to the FB understanding of children with ASD. Children with ASD who passed FB tasks all passedsay- andthink-complement tasks. However, some children in the control group were able to pass the FB tasks, even if they failed thesay- andthink-complement tasks.ConclusionThe results indicate that children with ASD relied more on complement understanding to pass FB than typically developing children. Results are discussed regarding the developmental pathways for FB understanding.
Neumoquiste Vertebral en Columna Lumbar: Reporte de un Caso y Revisión de la Literatura
Authors: Fleiderman José , Justiniano Pablo , Cirillo Ignacio , Wilkens Ana , Chiang Francisco 
Published: June 2017

ResumenLos neumoquistes intraóseos, son lesiones cavitadas de contenido gaseoso, las cuales generalmente son encontradas como hallazgos incidentales en exámenes imagenológicos a nivel sacroiliaco, pubis, sacro, clavícula, cabeza humeral, columna cervical, torácica y en menor medida, en la columna lumbar.La tomografía computarizada es el examen de elección para realizar la confirmación diagnóstica y descartar diagnósticos diferenciales, y su patrón característico se describe como una lesión de aspecto quística con atenuación por gas intralesión con rangos entre -950 y -580 H.El diagnóstico diferencial debe incluir otras posibles causas de gas intraóseo como osteomielitis, osteonecrosis, quistes óseos o subcondrales, entre otros.Si bien la progresión natural del neumoquiste intraoseo es desconocida, distintos autores han descrito que en seguimientos radiológicos hasta 4 años, el tamaño de las lesiones se mantiene estable, e incluso en otros casos se han resuelto de manera espontánea, sin embargo, en otros se ha reportado un crecimiento progresivo en seguimiento de 16 meses.En cuanto al manejo del neumoquiste intraóseo, en la mayoría de los casos reportados se ha observado una evolución benigna, con manejo conservador de las lesiones, sin embargo frente a lesiones de gran tamaño con riesgo de fractura patológica se debe plantear la posibilidad de manejo quirúrgico con corpectomía e injerto óseo.Debido a la escasa evidencia respecto de esa lesión, es que se reporta un caso de neumoquiste vertebral lumbar, describiendo su estudio, evolución y manejo.
The Impact of cfDNA Screening on the Frequency of Invasive Procedures in a Geographically Diverse Private Network
Authors: Combs C. , Maurel Kimberly , Abril Diana , Das Anita , Garite Thomas ,   and the Obstetrix Collaborative Research Network
Published: June 2017

Objective Cell-free fetal DNA (cfDNA) screening has had a dramatic impact in obstetrics. We examined the impact of cfDNA screening in a network of geographically diverse referral maternal–fetal medicine (MFM) private practices.
Study Design Data were derived from the genetic clinics of 16 testing centers from a wide geographic area and included all women undergoing either amniocentesis or chorionic villus sampling (CVS) during a 6-month control period versus a 30-month study period.
Results During the control period, there were 193 amniocenteses and 47 CVS/month. During the last 6 months of the study, amniocenteses dropped to 52/month and CVS to 18/month. Positive aneuploid test results per procedure increased from 6.9% during the control period to 15.0% during the last 6 months of the study period. However, the overall number of aneuploidy results decreased from 16.7/month to of 10.5/month.
Conclusion Our study demonstrates the dramatic changes in the era of cfDNA screening on reducing the frequency of amniocentesis and CVS associated with a higher percentage of positive results per procedure. There was an unexpected decrease in aneuploid fetuses diagnosed over the study period, which could reflect decisions regarding genetically abnormal fetuses being made without a definitive diagnostic procedure.
Familial Translocation t(5;15)(p14.2;q26.2) Causing a Mirror Combination of Several Known Genetic Conditions
Authors: Goldberg Yael , Berger Racheli , Peleg Amir , Sagi-Dain Lena 
Published: June 2017

AbstractTwo siblings with an unbalanced cytogenetic composition are described: a brother with partial trisomy 5p and distal 15q microdeletion, and a sister with partial monosomy 5p and distal 15q microduplication, resulting from a familial balanced translocation 46,XY; t(5;15)(p14.2;q26.2). To our best knowledge, there are no previous clinical and cytogenetic reports in the literature describing a family with concomitant presence of such a unique mirror combination. Clinical features of pure imbalances and the effects of their combination are discussed.
Embodied argumentation in public debates
Authors: Jacquin Jérôme 
Published: June 2017

Abstract
This chapter examines argumentative talk-in-interaction in video-recorded public debates held in Switzerland, during which all the participants were temporally and spatially co-present. It focuses on the issue of segmenting talk into argumentative moves, by looking at the way gestures combine with the verbal mode to enhance and display the different steps of the ongoing argumentation (e.g. when the speaker moves from one argument to another, or from an argument to the conclusion). In other words, while the embodied dimension of argumentation in talk-in-interaction remains largely unexplored, the chapter provides empirical evidence for the way argumentation is multimodally produced and processed in context. Three specific gestures are considered: gestures claiming the floor, gestures pointing to a participant, and metaphoric grasping gestures. The chapter concludes with suggestions for further lines of research.
Incident Trichomonas vaginalis Is Associated With Partnership Concurrency: A Longitudinal Cohort Study
Authors: Kenyon Chris R. , Buyze Jozefien , Klebanoff Mark , Brotman Rebecca M. 
Published: June 2017

Background
Sexual partner concurrency (PC) has been shown to be a risk factor for a number of sexually transmitted infections but it is unknown if it is a risk factor for Trichomonas vaginalis (TV).

Objective
We assess if there is an association between PC and incident TV infection.

Study Design
We used mixed effects logistic regression to assess the association between PC and incident TV in the Longitudinal Study of Vaginal Flora, a cohort study of 3620 women followed quarterly for 5 visits.

Results

Trichomonas vaginalis was more common in those reporting definite/possible/unknown PC (15.6%/15.0%/18.3%) than those reporting no PC (5.2%; P < 0.001 for all 3 comparisons). After controlling for a range of confounders, incident TV remained associated with reporting that one's partner definitely (adjusted odds ratio, 5.4; 95% confidence interval, 3.7–8.0) and possibly (adjusted odds ratio, 3.4; 95% confidence interval, 2.2–5.1) engaged in PC in the preceding period.

Conclusions
Partner concurrency was associated with incident TV infection.
A Single Question to Examine the Prevalence and Protective Effect of Seroadaptive Strategies Among Men Who Have Sex With Men
Authors: Khosropour Christine M. , Dombrowski Julia C. , Katz David A. , Golden Matthew R. 
Published: June 2017

Background
Seroadaptive behaviors among men who have sex with men (MSM) are common, but ascertaining behavioral information is challenging in clinical settings. To address this, we developed a single seroadaptive behavior question.

Methods
Men who have sex with men 18 years or older attending a sexually transmitted disease clinic in Seattle, WA, from 2013 to 2015, were eligible for this cross-sectional study. Respondents completed a comprehensive seroadaptive behavior questionnaire which included a single question that asked HIV-negative MSM to indicate which of 12 strategies they used in the past year to reduce their HIV risk. HIV testing was performed per routine clinical care. We used the κ statistic to examine agreement between the comprehensive questionnaire and the single question.

Results
We enrolled HIV-negative MSM at 3341 (55%) of 6105 eligible visits. The agreement between the full questionnaire and single question for 5 behaviors was fair to moderate (κ values of 0.34–0.59). From the single question, the most commonly reported behaviors were as follows: avoiding sex with HIV-positive (66%) or unknown-status (52%) men and using condoms with unknown-status partners (53%); 8% of men reported no seroadaptive behavior. Men tested newly HIV positive at 38 (1.4%) of 2741 visits. HIV test positivity for the most commonly reported behaviors ranged from 0.8% to 1.3%. Men reporting no seroadaptive strategy had a significantly higher HIV test positivity (3.5%) compared with men who reported at least 1 strategy (1.3%; P = 0.02).

Conclusions
The single question performed relatively well against a comprehensive seroadaptive behaviors assessment and may be useful in clinical settings to identify men at greatest risk for HIV.
Classifying Adverse Events in the Dental Office
Authors: Kalenderian Elsbeth , Obadan-Udoh Enihomo , Maramaldi Peter , Etolue Jini , Yansane Alfa , Stewart Denice , White Joel , Vaderhobli Ram , Kent Karla , Hebballi Nutan B. , Delattre Veronique , Kahn Maria , Tokede Oluwabunmi , Ramoni Rachel B. , Walji Muhammad F. 
Published: June 2017

Background
Dentists strive to provide safe and effective oral healthcare. However, some patients may encounter an adverse event (AE) defined as “unnecessary harm due to dental treatment.” In this research, we propose and evaluate two systems for categorizing the type and severity of AEs encountered at the dental office.

Methods
Several existing medical AE type and severity classification systems were reviewed and adapted for dentistry. Using data collected in previous work, two initial dental AE type and severity classification systems were developed. Eight independent reviewers performed focused chart reviews, and AEs identified were used to evaluate and modify these newly developed classifications.

Results
A total of 958 charts were independently reviewed. Among the reviewed charts, 118 prospective AEs were found and 101 (85.6%) were verified as AEs through a consensus process. At the end of the study, a final AE type classification comprising 12 categories, and an AE severity classification comprising 7 categories emerged. Pain and infection were the most common AE types representing 73% of the cases reviewed (56% and 17%, respectively) and 88% were found to cause temporary, moderate to severe harm to the patient.

Conclusions
Adverse events found during the chart review process were successfully classified using the novel dental AE type and severity classifications. Understanding the type of AEs and their severity are important steps if we are to learn from and prevent patient harm in the dental office.
Evaluating a Collaborative Approach to Improve Prior Authorization Efficiency in the Treatment of Hepatitis C Virus
Authors: Dunn Emily E. , Vranek Kathryn , Hynicka Lauren M. , Gripshover Janet , Potosky Darryn , Mattingly T. Joseph 
Published: June 2017

Objective:
A team-based approach to obtaining prior authorization approval was implemented utilizing a specialty pharmacy, a clinic-based pharmacy technician specialist, and a registered nurse to work with providers to obtain approval for medications for hepatitis C virus (HCV) infection. The objective of this study was to evaluate the time to approval for prescribed treatment of HCV infection.

Methods:
A retrospective observational study was conducted including patients treated for HCV infection by clinic providers who received at least 1 oral direct-acting antiviral HCV medication. Patients were divided into 2 groups, based on whether they were treated before or after the implementation of the team-based approach. Student t tests were used to compare average wait times before and after the intervention.

Results:
The sample included 180 patients, 68 treated before the intervention and 112 patients who initiated therapy after. All patients sampled required prior authorization approval by a third-party payer to begin therapy. There was a statistically significant reduction (P = .02) in average wait time in the postintervention group (15.6 ± 12.1 days) once adjusted using dates of approval.

Conclusions:
Pharmacy collaboration may provide increases in efficiency in provider prior authorization practices and reduced wait time for patients to begin treatment.
Exploring the Relationship Between Volume and Outcomes in Hospital Cardiovascular Care
Authors: Langabeer James R. , Kim Junghyun , Helton Jeffrey 
Published: June 2017

Background:
Management theories of learning and experience curve effects state that greater levels of scale produce learnings and improved performance. In cardiovascular care, guidelines suggest that high-volume facilities produce better patient outcomes; yet, there are contradictory findings from the few studies conducted. Our goals were to assess the volume-outcome relationship for interventional cardiovascular care.

Methods:
We examined 9360 patients with ST-segment elevation myocardial infarction who underwent percutaneous intervention (PCI). We analyzed 6 years of data (2010-2015) using systematic extracts provided by 33 PCI-capable hospitals in the Dallas Texas region from the National Cardiovascular Data Registry. We stratified hospitals into 3 procedural volume categories (low, intermediate, and high) to identify changes in 2 key outcome metrics (ie, door-to-balloon times and mortality). Multivariate analyses and tests of differences were utilized.

Results:
Door-to-balloon performance outcome was significantly different between volume categories, with the highest-volume hospitals performing significantly better than intermediate- and low-volume hospitals (47, 60, and 75 minutes, respectively; P < .001). Mortality followed a similar pattern, with a 3.3% unadjusted absolute lower mortality rate for the high-volume hospitals. Multivariate regressions confirm that volume is statistically significant in both mortality and treatment times.

Conclusions:
Higher-volume PCI hospitals have 37% shorter treatment times and 53% lower mortality rates than smaller facilities. This study provides evidence of a positive volume-outcome relationship in interventional cardiovascular care.
Intracranial Aneurysms of Neuro-Ophthalmologic Relevance
Authors: Micieli Jonathan A. , Newman Nancy J. , Barrow Daniel L. , Biousse Valérie 
Published: June 2017

Background:
Intracranial saccular aneurysms are acquired lesions that often present with neuro-ophthalmologic symptoms and signs. Recent advances in neurosurgical techniques, endovascular treatments, and neurocritical care have improved the optimal management of symptomatic unruptured aneurysms, but whether the chosen treatment has an impact on neuro-ophthalmologic outcomes remains debated.

Evidence Acquisition:
A review of the literature focused on neuro-ophthalmic manifestations and treatment of intracranial aneurysms with specific relevance to neuro-ophthalmologic outcomes was conducted using Ovid MEDLINE and EMBASE databases. Cavernous sinus aneurysms were not included in this review.

Results:
Surgical clipping vs endovascular coiling for aneurysms causing third nerve palsies was compared in 13 retrospective studies representing 447 patients. Complete recovery was achieved in 78% of surgical patients compared with 44% of patients treated with endovascular coiling. However, the complication rate, hospital costs, and days spent in intensive care were reported as higher in surgically treated patients. Retrospective reviews of surgical clipping and endovascular coiling for all ocular motor nerve palsies (third, fourth, or sixth cranial nerves) revealed similar results of complete resolution in 76% and 49%, respectively. Improvement in visual deficits related to aneurysmal compression of the anterior visual pathways was also better among patients treated with clipping than with coiling. The time to treatment from onset of visual symptoms was a predictive factor of visual recovery in several studies. Few reports have specifically assessed the improvement of visual deficits after treatment with flow diverters.

Conclusions:
Decisions regarding the choice of therapy for intracranial aneurysms causing neuro-ophthalmologic signs ideally should be made at high-volume centers with access to both surgical and endovascular treatments. The status of the patient, location of the aneurysm, and experience of the treating physicians are important factors to consider. Although a higher rate of visual recovery was reported with neurosurgical clipping, this must be weighed against the potentially longer intensive care stays and increased early morbidity.
Analyzing technical and super efficiency of aluminium firms in India
Authors: Kundi Mini , Sharma Seema 
Published: June 2017

PurposeThe purpose of this paper is to evaluate the efficiency of aluminium firms in India.Design/methodology/approachDifferent data envelopment analysis (DEA) models have been employed to calculate the various efficiency scores of aluminium firms in India.FindingsThe major findings of the DEA analysis suggest that 62 per cent firms are found to be technically efficient. Overall, the industry shows good performance with mean technical efficiency levels of 0.936 and 0.911 for VRS and CRS frameworks, respectively. Further, five firms show decreasing returns to scale, signifying the overutilization of plant capacities. Six firms exhibit increasing returns to scale implying underutilization of plants. The results show that domestic firms are more efficient than the foreign firms, young firms are more efficient than young firms and small- and medium-scale firms are more efficient than large-scale firms.Practical implicationsThe results of this study would help the aluminium firms to formulate an appropriate strategy to cautiously use their resources to increase their efficiency levels.Originality/valueTo the best of authors’ knowledge, no earlier studies seem to have ranked the aluminium firms based on their super-efficiency scores. Further, no previous studies seem to have examined the efficiency differences among aluminium firms across different size, age and ownership groups.