bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kaempferol activates chloride secretion via the cAMP/PKA signaling pathway and expression of CFTR in T84 cells
Authors: Thaweewattanodom Janjira , Deachapunya Chatsri , Poonyachoti Sutthasinee 
Published: September 2024

Kaempferol is a flavonol identified as the most potent activator of chloride (Cl−) secretion among other flavonoids in airway epithelial cells. This study aimed to investigate the cellular mechanisms by which kaempferol stimulates Cl− secretion in the T84 human colon carcinoma cell line by Ussing chambers and voltage clamp technique. Bilateral addition of kaempferol (1–100 µM) increased short-circuit current (Isc) in a concentration-dependent manner. Ion substitution of Cl− or CFTR inhibitors NPPB and glibenclamide or a Na+/K+/2Cl− cotransporter inhibitor bumetanide attenuated kaempferol-induced Isc response. In permeabilized monolayers, selective channel inhibitors CFTRinh-172 and CaCCinh-A01 inhibited kaempferol-induced apical Cl− current (ICl), and K+ blockers BaCl2 and clotrimazole inhibited basolateral K+ current (IKb). The kaempferol-induced ICl showed no additive effects with forskolin or 8cpt-cAMP. The kaempferol-induced ICl was mostly abolished by protein kinase A inhibitor H89, but not by tyrosine kinase inhibitors, AG490 and tyrphostin A23, or tyrosine phosphatase inhibitor vanadate. Treatment with kaempferol for 24 h increased the expression of CFTR protein as determined by the Western blot analysis. These results demonstrated that kaempferol activates Cl− secretion across T84 cells by activating the apical Cl− current and basolateral K+ current. The mechanisms may involve the cAMP/PKA pathway and CFTR expression. Taken together, these findings reveal the beneficial effects of kaempferol to increase fluid secretion which can be used to treat constipation.
Automated size-specific dosimetry for chest posterior–anterior projection radiography
Authors: Dedulle An , Fitousi Niki , Marshall Nicholas , Bosmans Hilde 
Published: September 2024

IntroductionChest radiography is a frequently performed examination, and therefore, accurate patient dosimetry is important. One means of increasing dosimetric accuracy is through the use of size-specific dosimetry, and the aim of this work was to determine which patients would benefit from such a methodology applied in chest posterior–anterior (PA) projection radiography.MethodsA database of 44 voxel models was created from CT scans, representing adults with BMI from underweight, normal, overweight, and obese classes. Monte Carlo simulation was performed to generate dose conversion factors for each model. Correlation curves of the dose conversion factors with water equivalent diameter (WED) of the 44 voxel phantoms were obtained. A total of 8,536 chest PA examinations acquired between 2015 and 2019 using three X-ray systems were then retrospectively collected; 4,748 men (median age: 61 ± 21 years) and 3,788 women (median age: 60 ± 23 years). The WED of the patients was estimated from the ratio of detector air-kerma to incident air-kerma, using parameters in the DICOM header of the images. For all patients, a size-specific conversion factor was selected automatically using the relation between WED and dose conversion factor determined for the phantoms. The size-specific organ doses and effective doses were calculated based on these conversion factors, and then compared to the standard effective dose calculation with a paired test.ResultsThe lung doses ranged from 7 μGy to 96 μGy and had a good correlation with patient size in terms of WED (p &lt; 0.01, R² between 0.52 and 0.77). The doses for thyroid ranged from 2 μGy to 42 μGy and correlated strongly with the patient size (p &lt; 0.01, R² between 0.65 and 0.85). Breast doses ranged from 2 μGy to 13 μGy, and the correlation with the patient size was weak (p &lt; 0.01, R2 between 0.01 and 0.28). The size-specific effective dose ranged from 4 μSv to 42 μSv. The difference between the size-specific and standard effective dose ranged from −35% to 69% (p &lt; 0.01), with differences exceeding ± 20% for 37% of the cases.DiscussionIn conclusion, the method presented in this study enables automated size-specific dosimetry, within the proposed maximum deviation of ± 20%, and should be considered for routine application.
The impact of simulated 3x3 tournament on vertical jump force-time metrics in national team male basketball players
Authors: Cabarkapa Dimitrije , Aleksic Jelena , Krsman Darko , Cabarkapa Damjana V. , Philipp Nicolas M. , Fry Andrew C. 
Published: September 2024

With innovative portable force plate systems being widely implemented for lower-body neuromuscular performance assessment in an applied sports setting and the existing gap in the scientific literature regarding player performance during in-game competitive scenarios, the purpose of the present study was to compare changes in countermovement vertical jump (CVJ) performance pre-post a simulated 3×3 basketball tournament. Seven current or former members of a 3×3 national basketball team volunteered to participate in the present investigation. Upon completing standardized warm-up procedures, athletes stepped on a uni-axial force plate system sampling at 1,000 Hz and performed three maximal-effort CVJs with no arm swing. Then, the athletes proceeded to play a simulated 3×3 basketball tournament composed of two consecutive games, separated by a 15-min rest interval. Immediately following the completion of the second game, the identical CVJ testing procedures were repeated. Paired sample t-tests were used to examine pre-post-tournament differences in nineteen CVJ performance metrics (p &lt; 0.05). The results reveal that force-time metrics during both eccentric and concentric phases of the CVJ remain relatively unchanged pre-post simulated 3×3 basketball tournament. However, multiple force-time metrics within the eccentric phase of the CVJ changed by 12.1%–19.1% (e.g., eccentric peak power and peak velocity, eccentric duration), suggesting that the eccentric phase of CVJ might be responsive to performance stimulus to a greater extent than the concentric phase. Overall, these findings further support the importance of comprehensive CVJ analysis when intending to measure changes in neuromuscular performance.
The role of affective temperaments in self-care and medication adherence among individuals with bipolar disorder: a moderation analysis
Authors: Visalli Giulia , Longobardi Grazia , Iazzolino Anna Maria , D’Angelo Martina , Stefano Valeria Di , Paribello Pasquale , Steardo Luca , Manchia Mirko , Steardo Luca 
Published: September 2024

BackgroundAffective temperament, defined as the fundamental predisposition from which normal affective states originate or as the constitutional core of personality, play a crucial role in mood disorders, particularly bipolar disorders. Understanding the relationship between temperaments, treatment adherence, and self-care is crucial for effective management and improved clinical results.ObjectivesThis study aims to (1) assess the correlation between affective temperaments and treatment adherence, (2) investigate the relationship between affective temperaments and self-care abilities, (3) identify predictors of treatment adherence, and (4) explore the moderating effect of self-care on the relationship between treatment adherence and depressive temperament in individuals with bipolar disorder.MethodsA cross-sectional study was conducted with 231 individuals diagnosed with bipolar disorder (BD) type I (N=160) and type II (N=71). The participants were evaluated using the following psychometric tools: Temperament Evaluation of Memphis, Pisa, and San Diego (TEMPS) to assess affective temperaments, Personal and Social Performance Scale (PSP) to evaluate social functioning and self-care abilities, and Morisky Medication Adherence Scale (MMAS) to measure treatment adherence. The study involved statistical analyses to examine correlations, identify predictors, and explore moderating effects.ResultsThe findings revealed significant correlations between affective temperaments and both treatment adherence and self-care abilities. Specifically, hyperthymic temperament was positively associated with higher treatment adherence, whereas cyclothymic and depressive temperaments were linked to lower adherence. Self-care abilities were found to mediate the relationship between depressive temperament and treatment adherence, suggesting that improved self-care can enhance adherence in individuals with depressive temperament.ConclusionsAffective temperaments significantly influence treatment adherence and self-care abilities in individuals with bipolar disorder. The mediating role of self-care highlights the importance of developing targeted interventions to improve self-care practices, thereby enhancing treatment adherence and overall well-being. Personalized treatment strategies based on temperament assessments could lead to better clinical outcomes and quality of life for individuals with bipolar disorder.
Health-related quality of life assessed by EQ-5D-5L and its determinants among Chinese adults
Authors: Bai Gengliang , Zhang Jiawen , Chen Yijun , Cao Lejing , Yang Yong , Jiang Chao 
Published: September 2024

BackgroundDue to the rising standard of living and advances in public health and medical care in recent years in China, the health-related quality of life (HRQoL) has been increasingly acknowledged as an important part of health management of adults. This study aimed to analyze the HRQoL of Chinese adults and identify the influencing factors, proposing specific recommendations for improvement.MethodsA cross-sectional study was conducted among 1,291 selected adults from four provinces spanning different regions in China aged ≥18 years from July 2021 and January 2022. The EuroQol-5D-5L (EQ-5D-5L) was used to conduct the HRQoL survey, and a general questionnaire was administered to collect demographic characteristics, general information, and health behaviors of participants. The health utility value was measured, and one-way analysis of variance was performed. The Tobit regression model was employed to analyze the factors influencing the HRQoL of Chinese adults.ResultsThe mean health utility values and visual analog scale scores for adults were 0.9400 ± 0.1197 and 84.09 ± 14.392, respectively. Notably, 60.3% of respondents reported no difficulties in any of the five dimensions of EQ-5D. However, a substantial proportion faced challenges in anxiety/depression (27%) and pain/discomfort (26.2%). Tobit regression model revealed that age, marital status, educational level, diet, sleep, mental state, mood, and chronic diseases significantly impact the HRQoL of Chinese adults.ConclusionThe HRQoL among Chinese adults is generally satisfactory, but pay particular attention on areas such as pain, psychological anxiety, chronic diseases, and negative emotions is needed. The factors such as stress associated with marriage and the demands of high-skilled occupations might influence the overall health of the population. According to our findings, public health strategies to improve HRQoL should be developed to promote relatively healthy environments and lifestyles for older adults. Moreover, proactive measures are crucial for mitigating the potential health impacts associated with marital stress and high-skilled employment.
Non-biological factors associated with postpartum depression among women in Shenzhen: a case-control study
Authors: He Jiangshan , Li Yang , Chen Ling , Zhang Ying 
Published: September 2024

BackgroundPostpartum depression (PPD) presents a significant public health challenge. While PPD’s impact extends from maternal health to child development, cultural stigma and a lack of public awareness, particularly in developing countries, contribute to its underestimation and under diagnosed. This study investigated the non-biological associated factors for PPD in Shenzhen city due to its unique socioeconomic landscape, where rapid urbanization and migrant influx could uniquely impact maternal mental health. By identifying local PPD determinants, the research aimed to contribute to targeted mental health interventions in the region.MethodData were collected from May to December 2019 at the Luohu Maternal and Child Health Medical Center, Shenzhen. Inclusion criteria were postpartum women without psychiatric histories who live within the locality. The Chinese Edinburgh Postnatal Depression Scale was utilized to confirm PPD diagnosis. Participant information including demographics, economic status and postnatal factors were collected via structured questionnaires. Statistical analyses of t-tests, Wilcoxon rank-sum tests, chi-square tests, and logistic regression, were performed using SPSS 20.0, with significance set at p ≤ 0.05.ResultsThe study included 430 healthy mothers and 73 PPD mothers. Several factors were found to significantly influence the onset of PPD (p &lt; 0.05): age (OR = 0.921, 95% CI: 0.864–0.981); living with in-laws (OR = 2.133, 95% CI: 1.108–4.106); bottle feeding (OR = 3.757, 95% CI: 1.567–9.006); prenatal depression (OR = 3.515, 95% CI: 1.61–7.675); prenatal anxiety (OR = 6.072, 95% CI: 3.209–11.49); and adverse life events during pregnancy (OR = 3.287, 95% CI: 1.165–9.269). Other factors were not found to have a significant effect.ConclusionOur study found that in the developed city of Shenzhen in Southern China, living with in-laws, exclusive bottle feeding, prenatal anxiety, depression, and adverse life events are non-biological associated factors for postpartum depression. The findings emphasize the importance of considering a range of factors when addressing maternal mental health within a specific local regions. It calls for targeted interventions or prevention program that take into considering the specific cultural, social, and individual factors.
National survey questionnaire on the diagnosis and treatment status of Helicobacter pylori in peptic ulcer bleeding disease
Authors: Jiang Zongdan , Ding Yaokun , Li Chao , Zhang Zhenyu 
Published: September 2024

Background and objectiveThe Maastricht VI/Florence Consensus and Chinese National Consensus Report provide comprehensive guidelines for treating Helicobacter pylori infection. This study aimed to assess physicians' understanding of and adherence to this consensus in different hospitals.MethodsChinese medical staff attending gastrointestinal conferences across various regions were selected for this study. The questionnaire included: 1. the number of patients with peptic ulcer bleeding in hospitals of different levels annually and the diagnostic methods used for H. pylori; 2. whether routine H. pylori examination was conducted and the specific methods employed; and 3. Treatment plans for H. pylori eradication; 4. The mean follow-up duration after treatment 5. Plans for re-eradication in cases of H. pylori treatment failure.ResultsAcross all levels of Chinese hospitals, the urea breath test was the most commonly used method for detecting H. pylori infection. Most primary (81.53%), secondary (89.49%), and tertiary (91.42%) centers opted for a 14-day quadruple regimen. The preferred antibiotic regimen at all hospital levels was amoxicillin+clarithromycin, with rates of 63.69, 58.08, and 59.27% in the primary, secondary, and tertiary hospitals, respectively. The rates of H. pylori re-examination were 68.15, 87.07, and 87.46% in the primary, secondary, and tertiary hospitals. If H. pylori eradication failed, hospitals at different levels choose to replace the initial plan.ConclusionThere is a need for an enhanced understanding of and adherence to guidelines for H. pylori among physicians in hospitals at all levels.
The association between accelerated biological aging and the risk of osteoarthritis: a cross-sectional study
Authors: He Qiang , Luo Hua , Mei Jie , Wang Zhen , Sun Xin , Wang Ling , Xie Chengxin 
Published: September 2024

BackgroundBiological age (BA) offers an effective assessment of true aging state. The progression of Osteoarthritis (OA) is closely associated with an increase in chronological age, the correlation between BA and OA has not been fully elucidated.MethodsThis study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2005–2018. Thirteen commonly used clinical traits were employed to calculate two measures of BA: the Klemera-Doubal method age (KDM-Age) and phenotypic age (Pheno-Age). The residuals of the regression of these ages based on chronological age were calculated as KDM-Age or Pheno-Age acceleration, respectively. OA was determined through self-reported prior diagnoses. The prevalence of OA across different quartiles of BA was compared using weighted chi-square tests and linear trend tests. The association between BA and OA was assessed using weighted multivariate logistic regression models.ResultsA total of 30,547 participants aged ≥20 years were included in this study, 3,922 (14%) were diagnosed with OA. Participants with OA exhibited higher chronological age, KDM-Age, Pheno-Age, KDM-Age advance, and Pheno-Age advance compared to those without OA (p &lt; 0.001). The prevalence of OA significantly increased with higher quartiles of KDM-Age advance and Pheno-Age advance (P for trend &lt; 0.001). In the fully adjusted model, compared to the lowest quartile (Q1) of KDM-Age advance, the highest quartile (Q4) was associated with a 36.3% increased risk of OA (OR = 1.363; 95% CI = 1.213 to 1.532, p &lt; 0.001). The highest quartile of Pheno-Age advance (Q4) was associated with a 24.3% increased risk of OA compared to Q1 (OR = 1.243; 95% CI = 1.113 to 1.389, p &lt; 0.001). In males and young people, no statistical differences were found in OA risk between the highest and the lowest quartiles of KDM-Age advance (p = 0.151) and Pheno-Age advance (p = 0.057), respectively.ConclusionAdults with accelerated biological aging have an increased risk of OA, particularly among females and older adults.
Esports buffs: the perceived role of fans and fandoms in U.S. collegiate programs
Authors: Cote Amanda C. , Rahman Md Waseq Ur , Foxman Maxwell , Wilson Andrew , Harris Brandon C. , Can Onder , Hansen Jared C. 
Published: September 2024

IntroductionCollegiate esports—organized competitive gaming—has expanded rapidly in the United States, drawing in student players, broadcasters, and support staff, as well as university employees. Universities have invested financially in esports, hoping to capitalize on gaming fandom to attract prospective students and enhance campus community integration. Little research, however, addresses collegiate esports fandom in depth.MethodsDrawing on thirty-one in-depth interviews with collegiate esports players, student workers, program directors, and administrators, this article investigates how collegiate esports participants perceive and discuss their fans.ResultsWe identify three central themes related to fans in the dataset: discussions of fans’ role in the collegiate esports environment, comparisons between esports and traditional sports fans, and concerns about the underutilization of fans within collegiate esports spaces. Subsequently, we theorize these themes through existing research on professional esports and traditional collegiate sports fandoms, as well as through the concept of “fan labor,” or how the productive work of fans provides value to the nascent industry.DiscussionThis article thus not only specifically explores how collegiate esports programs are normalizing fan labor as an essential part of their practices, but also questions who benefits from this relationship and how. Investigating collegiate esports fans as an under-researched group additionally provides a new perspective on how fan labor integrates with media industries more broadly.
An investigation into China’s online catering food safety governance efficacy based on the strategies of frequent supervision and strict penalty
Authors: Shen Cong , Wei Mingxia , Li Chaoyang , Hao Xin , Wang Lin 
Published: September 2024

IntroductionEnhancing the efficacy of online food safety supervision requires thoughtful selection and efficient application of regulatory measures.MethodsThis study examined the current state of online food safety supervision in the important food producing city in central China of Zhengzhou. The effectiveness of supervision frequency and penalty on food safety governance of online catering was examined through model construction based on the optimal law enforcement theory. The efficacy of monitoring was evaluated using real supervision and punishment data from the online catering sector in a Chinese new first-tier city.Results and discussionResults showed that although high-frequency and high-penalty supervision are two common methods of online food safety governance, the deterrent effect of high-frequency supervision on online food businesses is more significant for improving the supervision efficiency of the online catering market. Simultaneously, bolstering the education of caterers and food operators as well as raising their degree of training are also efficient ways to raise the efficacy of government oversight. The application of law enforcement economics is broadened in this study, which also has implication for the advancement of credit rating and classification supervision in the area of food safety for online catering.
Knowledge mapping and bibliometric analysis of medical knee magnetic resonance imaging for knee osteoarthritis (2004–2023)
Authors: Chen Juntao , Xu Hui , Zhou Hang , Wang Zheng , Li Wanyu , Guo Juan , Zhou Yunfeng 
Published: September 2024

ObjectivesMagnetic resonance imaging (MRI) is increasingly used to detect knee osteoarthritis (KOA). In this study, we aimed to systematically examine the global research status on the application of medical knee MRI in the treatment of KOA, analyze research hotspots, explore future trends, and present results in the form of a knowledge graph.MethodsThe Web of Science core database was searched for studies on medical knee MRI scans in patients with KOA between 2004 and 2023. CiteSpace, SCImago Graphica, and VOSviewer were used for the country, institution, journal, author, reference, and keyword analyses.ResultsA total of 2,904 articles were included. The United States and Europe are leading countries. Boston University is the main institution. Osteoarthritis and cartilage is the main magazine. The most frequently cocited article was “Radiological assessment of osteoarthrosis”. Guermazi A was the author with the highest number of publications and total references. The keywords most closely linked to MRI and KOA were “cartilage”, “pain”, and “injury”.ConclusionsThe application of medical knee MRI in KOA can be divided into the following parts: (1). MRI was used to assess the relationship between the characteristics of local tissue damage and pathological changes and clinical symptoms. (2).The risk factors of KOA were analyzed by MRI to determine the early diagnosis of KOA. (3). MRI was used to evaluate the efficacy of multiple interventions for KOA tissue damage (e.g., cartilage defects, bone marrow edema, bone marrow microfracture, and subchondral bone remodeling). Artificial intelligence, particularly deep learning, has become the focus of research on MRI applications for KOA.