bluuebunny/crossref_metadata_2025_split huggingface dataset:
Light signaling‐dependent regulation of plastid RNA processing in Arabidopsis
Authors: Hu Lili , Wu Qian , Wu Chunyu , Zhang Chunmei , Wu Ziying , Shi Meihui , Zhang Man , Duan Sujuan , Wang Hong‐Bin , Jin Hong‐Lei 
Published: October 2024

ABSTRACTLight is a vital environmental signal that regulates the expression of plastid genes. Plastids are crucial organelles that respond to light, but the effects of light on plastid RNA processing following transcription remain unclear. In this study, we systematically examined the influence of light exposure on plastid RNA processing, focusing on RNA splicing and RNA editing. We demonstrated that light promotes the splicing of transcripts from the plastid genes rps12, ndhA, atpF, petB, and rpl2. Additionally, light increased the editing rate of the accD transcript at nucleotide 794 (accD‐794) and the ndhF transcript at nucleotide 290 (ndhF‐290), while decreasing the editing rate of the clpP transcript at nucleotide 559 (clpP‐559). We have identified key regulators of signaling pathways, such as CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1), ELONGATED HYPOCOTYL 5 (HY5), and PHYTOCHROME‐INTERACTING FACTORs (PIFs), as important players in the regulation of plastid RNA splicing and editing. Notably, COP1 was required for GENOMES UNCOUPLED1 (GUN1)‐dependent repression of clpP‐559 editing in the light. We showed that HY5 and PIF1 bind to the promoters of nuclear genes encoding plastid‐localized RNA processing factors in a light‐dependent manner. This study provides insight into the mechanisms underlying light‐mediated post‐transcriptional regulation of plastid gene expression.
Decomposing Supply‐ and Demand‐Driven Inflation
Authors: SHAPIRO ADAM HALE 
Published: October 2024

AbstractThe extent to which either supply or demand factors drive inflation has important implications for economic policy. I propose a framework to decompose inflation into supply‐ and demand‐driven components. I generate two new data series that quantify the degree to which either demand or supply is driving inflation in a current month. The demand‐driven contribution tends to decline during recessions, while the supply‐driven contribution tends to follow food and energy prices. Monetary policy tightening acts to reduce the demand‐driven contribution of inflation. Oil‐supply shocks act to increase the supply‐driven contribution, but decrease the demand‐driven contribution of inflation.
(In)Stability of the Relationship between Relative Expenditure and Price of Durable and Nondurable Goods
Authors: BHATT VIPUL , KISHOR N. KUNDAN 
Published: October 2024

AbstractUsing an intertemporal consumption model with nondurable and durable goods, we identify a break in the long‐run equilibrium relationship between their relative expenditure and relative prices. From 1959 to 1981, these goods were gross substitutes with an elasticity greater than one. Post‐1981, the estimated elasticity is below one, indicating complementarity. This shift altered short‐run dynamics with durable goods still driving error correction but the magnitude of adjustment is smaller. The cyclical component of durable goods consumption has become more persistent, suggesting that shocks, such as the COVID‐19 pandemic, now result in more prolonged deviations from the long‐run equilibrium.
Does Regulation Only Bite the Less Profitable? Evidence from the Too‐Big‐To‐Fail Reforms
Authors: GOEL TIRUPAM , LEWRICK ULF , MATHUR AAKRITI 
Published: October 2024

AbstractWhat shapes banks' response to capital requirement reforms? While prereform capitalization is important in the short term, we posit that profitability is key in the medium term, as it underpins banks' capacity to build capital. We examine the impact of capital surcharges on systemically important banks. Through a novel application of textual analysis to identify when banks react, we show that less profitable banks contract when faced with higher requirements, especially if they are closer to the thresholds that determine their surcharges. Conversely, more profitable banks continue to expand, improving banking efficiency but raising concerns about concentration and exposure to tail risks.
Sex and Gender Variables in Data Set Creation and Data Cleaning for Inclusive and Accurate Reproductive Health Research and Quality Improvement
Authors: Phillippi Julia C. , Wiese Andrew , Loch Sarah F. , Wei Wei‐Qi , Ong Henry H. , Gonzales Gilbert , Patrick Stephen W. 
Published: October 2024

IntroductionExisting data is often used for reproductive research and quality improvement. Electronic health records (EHRs) with a single data field for sex and gender conflate sex assigned at birth, genotype, gender identity, and the presence of anatomic tissue and organs. This is problematic for inclusion of transgender and gender‐diverse populations in research. This article discusses considerations with a single‐item sex and gender variable drawn from EHR records and describes an audit to determine variable validity as a criterion for inclusion or exclusion in perinatal research.MethodsIndividuals with a live birth at a large academic medical center from 2010 to 2022 were identified via electronic query, and records with male demographic information were reviewed to validate (1) the patient's date of birth and delivery date in the EHR matched the medical record number, (2) male sex and gender demographic information, and (3) male gender terms in EHR notes.ResultsAll health records of male birthing individuals (n = 8) had EHR evidence of giving birth within the health system during the timeframe, and the date of birth matched the medical record number of the EHR. All had male gender in the EHR demographic information. Six patients did not have any male gender terms in available EHR notes, only female gender terms. Two records had recent notes using male gender terms.DiscussionCurrent EHRs may not have reliable data on the gender and sex of gender‐diverse individuals. A single sex and gender variable drawn from EHRs should not be used as inclusion or exclusion criteria for health research or quality improvement without additional record review. EHRs can be updated to collect more data on sex, gender identity, and other relevant variables to improve research and quality improvement.
Alpha‐1 antitrypsin deficiency associated with increased risks of skin cancer, leukemia, and hepatic cancer: A nationwide cohort study
Authors: Korsbæk Nanna J. , Landt Eskild M. , Marott Sarah C. W. , Nordestgaard Børge G. , Vinding Gabrielle R. , Jemec Gregor B. E. , Dahl Morten 
Published: October 2024

ABSTRACTBackgroundα1‐Antitrypsin deficiency is characterized by elevated elastase activity and excessive elastin degradation, which may impact cancer development and progression. We tested the hypothesis that individuals with α1‐antitrypsin deficiency have increased susceptibility to cancer in the Danish population.MethodsIn a nationwide nested study, we identified 2702 individuals with α1‐antitrypsin deficiency and 26,750 control subjects without α1‐antitrypsin deficiency matched on age, sex, and municipality. We recorded admissions due to cancer as outcomes during a median follow‐up of 62 years.ResultsIndividuals with α1‐antitrypsin deficiency versus control subjects had an increased hazard of skin cancer (2.18, 95%CI: 1.81–2.63), leukemia (1.76, 1.12–2.79), liver cancer (3.91, 2.23–6.85), and cancer overall (1.25, 1.13–1.38). Corresponding hazard ratios when the entire Danish population was used as control group were 3.02 (2.55–3.58), 1.83 (1.19–2.81), 4.46 (2.74–7.28), and 1.45 (1.31–1.59). When the analysis was stratified according to comorbidities, the hazard for skin cancer was higher in those with chronic obstructive pulmonary disease (COPD) (3.59, 2.60–4.95) and skin disease (2.93, 2.19–3.92) but remained elevated in those without any of these diseases. Hazards for skin cancer in individuals with α1‐antitrypsin deficiency were similar when stratified by liver cirrhosis and ischemic heart disease (ps for interaction: ≥0.76). Hazards for liver cancer in individuals with α1‐antitrypsin deficiency versus control subjects were similar when stratified according to liver cirrhosis, COPD, skin disease, and ischemic heart disease (ps for interaction: ≥0.13).ConclusionIndividuals with α1‐antitrypsin deficiency have increased risks of skin cancer, leukemia, and liver cancer in the Danish population.
Gender inequality in intergenerational contact after parental separation in the digital era
Authors: Tosi Marco , Arpino Bruno 
Published: October 2024

AbstractObjectiveThe goal of this brief report is to analyze parent‐adult child contact frequency in intact and non‐intact families by focusing on parent and child gender and the type of contact.BackgroundParental separation increases gender differences in parent–child relationships, with separated fathers having less frequent contact with their adult children compared to separated mothers. We investigate whether the father–mother gap in post‐separation contact varies according to parent–child gender mismatch and the type of contact, that is, face‐to‐face, phone, or digital (e.g., via video calls).MethodWe use data on Italian families from the Family and Social Subjects survey to examine parent–child contact frequency among 6770 adult children aged 30–55 (11,041 parent–child dyads). We estimate random and fixed effects models on the probability of having frequent contact with biological parents in intact and non‐intact families (parental separation before age 18).ResultsFathers' reduced contact frequency compared to mothers is particularly evident with daughters, more pronounced in face‐to‐face and phone contact than in digital contact, and greater among younger daughters at the time of separation. Gender differences in phone and digital contact are larger for fathers who have also less frequent face‐to‐face contact compared to mothers.ConclusionWe interpret these findings by focusing on the centrality of mother–daughter ties and the loyalty that children have with the same‐gender parent. We also suggest that different types of contact reinforce gender differences between parents and may lead to a polarization of older parents with “strong” and “weak” family ties.
Seizing the moments and lessons learned from the global response to COVID‐19 pandemic: Creating a platform to shape the scientific and public discourse of research on adolescence
Authors: Murry Velma McBride 
Published: October 2024

AbstractCOVID‐19 response offers a model to guide research and preventive interventions targeting adolescents, their families, and communities. My 2022 SRA Presidential Address posed: What if the COVID‐19 Response Served as a Guidepost for Future Research on Adolescence? Solution versus Problem‐Focused Agenda. Several “pandemics” were already underway, emerging from historic and contemporary events that threaten the safety and survival of human lives. The Multi‐Transgenerational Life Course Theoretical model was selected to demonstrate pathways through which the transmission of generational exposure to crisis and trauma impact adolescents' developmental trajectories. Recommendations to inform and guide an adolescent research rapid response agenda are proposed minds to advance equity and social justice can become realities.
United States Provider Experiences With Telemedicine for Hepatitis C Treatment: A Nationwide Survey
Authors: Patel Pruthvi , Wells Martin T. , Wethington Elaine , Shapiro Martin , Parvez Yasir , Kapadia Shashi N. , Talal Andrew H. 
Published: October 2024

ABSTRACTHepatitis C virus (HCV) elimination requires treatment access expansion, especially for underserved populations. Telehealth has the potential to improve HCV treatment access, although data are limited on its incorporation into standard clinical practice. We conducted a cross‐sectional, email survey of 598 US HCV treatment providers who had valid email addresses and (1) were located in urban areas and had written ≥ 20 prescriptions for HCV treatment to US Medicare beneficiaries in 2019–2020 or (2) were located in non‐urban areas and wrote any HCV prescriptions in 2019–2020. Through email, we notified providers of a self‐administered electronic 28‐item survey of clinical strategies and attitudes about telemedicine for HCV. We received 86 responses (14% response rate), of which 75 used telemedicine for HCV in 2022. Of those 75, 24% were gastroenterologists/hepatologists, 23% general medicine, 17% infectious diseases and 32% non‐physicians. Most (82%) referred patients to commercial laboratories, and 85% had medications delivered directly to patients. Overwhelmingly, respondents (92%) felt that telehealth increases healthcare access, and 76% reported that it promotes or is neutral for treatment completion. Factors believed to be ‘extremely’ or ‘very’ important for telehealth use included patient access to technology (86%); patients' internet access (74%); laboratory access (76%); reimbursement for video visits (74%) and audio‐only visits (66%). Non‐physician licensing and liability statutes were rated ‘extremely’ or ‘very’ important by 43% and 44%, respectively. Providers felt that telehealth increases HCV treatment access. Major limitations were technological requirements, reimbursement, and access to ancillary services. These findings support the importance of digital equity and literacy to achieve HCV elimination goals.
Defining causes of death‐censored kidney allograft failure: A 5‐year multicentre ANZDATA and clinical cross‐sectional study
Authors: Mulley William R. , Hughes Peter D. , Collins Michael G. , Pilmore Helen L. , Clayton Philip A. , Wyld Melanie L. , Lee Darren , van der Jeugd Jane , Fernando Sanduni C. , Kuo Stephanie Fang‐Tzu , Tan Sarah , Jahan Sadia , Lim Wai H. 
Published: October 2024

AbstractAimDetermining specific causes of allograft failure allows a focus on understanding and treating these conditions. Previous studies highlight chronic antibody‐mediated rejection as a leading cause of late allograft failure. We sought to define causes of allograft failure in a large cohort of kidney transplant recipients across multiple centres in Australia and New Zealand, including cases previously attributed to chronic allograft nephropathy (CAN).MethodsAll death‐censored allograft failures at 9 participating centres between 1 January 2014 to 31 December 2018 were included. Available clinical and biopsy data were reviewed and the “most likely” cause assigned.ResultsThere were 642 death‐censored allograft failures in the study period. Of these, 495 (77.1%) had an informative biopsy performed a median of 13.4 months (IQR 2.5–39.1 months) prior to allograft failure. Rejection of any type was the leading cause of allograft failure (47.5%), comprised chiefly of chronic antibody‐mediated rejection (37.4%) and chronic T‐cell mediated rejection (6.4%). Other leading causes were undifferentiated interstitial fibrosis and tubular atrophy (10.8%), late medical and surgical complications (8.1%) and recurrent or de novo glomerulonephritis (7.0%). Polyoma viral nephropathy and calcineurin inhibitor toxicity each contributed to <2%. Causes of allograft failure previously attributed to CAN (n = 419, 65.3%) had a similar distribution to the overall cohort, with 43.9% attributed to chronic antibody‐mediated rejection.ConclusionTo prolong allograft survival, improved strategies are needed to curtail alloimmune responses. Greater understanding of the causes of undifferentiated interstitial fibrosis and tubular atrophy and potential treatments would also be of considerable benefit.
Hope experiences in pregnant women after artificial reproduction technology: Becoming a mother
Authors: Tseng Yun‐Min , Mu Pei‐Fan , Lai Ying‐Ming 
Published: October 2024

AbstractHope is a common phenomenon in human life. The process of infertile women being treated with assisted reproductive technology is difficult. The concept of hope can be applied in the nursing practice to help patients have a positive treatment experience, reduce feelings of despair, and find significance in difficult treatments. This study used phenomenological approach to understand the essential structure of the hope experiences of infertile women after successful artificial reproduction. A total of 10 infertile women who were successfully pregnant for more than 8 weeks and less than 24 weeks participated in this study. The essence of the hope experiences of infertile women after successful artificial reproduction was the process of “becoming a mother” which included four themes: (1) try hard to get pregnant; (2) outline a blueprint for the future of motherhood; (3) protect the fetus; and (4) integrate the fetus into the family. This study enabled medical teams to play the role of caregivers, intervened in hope care, and strengthened evidence‐based practice to improve the quality of care by focusing on feelings of hope.
Current Status and Factors Influencing Mental Health Literacy in Patients With Coronary Heart Disease: A Cross‐Sectional Study
Authors: Sun Cuiling , Chen Chunli , Feng Jun , Zhang Ting , Zhang Yuting , Pan Xiaona , Shi Ke 
Published: October 2024

ABSTRACTThis study aimed to investigate the current status of mental health literacy and related influencing factors in patients with coronary heart disease. Four hundred and thirty‐five patients with coronary heart disease were recruited in this survey. Data collection was conducted using the General Information Questionnaire, the Chinese version of the Mental Health Literacy Scale, Coronary Artery Disease Self‐Management Scale, Social Support Rating Scale, and Coronary Heart Disease Self‐Efficacy Scale. Descriptive methods, independent samples t‐test or one‐way ANOVA, Pearson's correlation analysis, and multiple linear regression were used for data analysis. The results showed that the mean total mental health literacy score of patients with coronary heart disease was 96.42 ± 8.40; gender, age, education level, monthly per capita family income, first diagnosed with coronary heart disease, cardiac function classification, self‐management ability, social support, and self‐efficacy were the factors influencing the level of mental health literacy in patients with coronary heart disease (all p < 0.05). The study suggests that mental health literacy can improve patients' self‐management ability and self‐efficacy, and healthcare professionals should emphasize the strengthening of this aspect of health education in order to better improve patient's prognosis.
New insights into the mechanisms of plant isotope fractionation from combined analysis of intramolecular 13C and deuterium abundances in Pinus nigra tree‐ring glucose
Authors: Wieloch Thomas , Holloway‐Phillips Meisha , Yu Jun , Niittylä Totte 
Published: October 2024

Summary
Understanding isotope fractionation mechanisms is fundamental for analyses of plant ecophysiology and paleoclimate based on tree‐ring isotope data.
To gain new insights into isotope fractionation, we analysed intramolecular 13C discrimination in tree‐ring glucose (Δi′, i = C‐1 to C‐6) and metabolic deuterium fractionation at H1 and H2 (εmet) combinedly. This dual‐isotope approach was used for isotope‐signal deconvolution.
We found evidence for metabolic processes affecting Δ1′ and Δ3′, which respond to air vapour pressure deficit (VPD), and processes affecting Δ1′, Δ2′, and εmet, which respond to precipitation but not VPD. These relationships exhibit change points dividing a period of homeostasis (1961–1980) from a period of metabolic adjustment (1983–1995). Homeostasis may result from sufficient groundwater availability. Additionally, we found Δ5′ and Δ6′ relationships with radiation and temperature, which are temporally stable and consistent with previously proposed isotope fractionation mechanisms.
Based on the multitude of climate covariables, intramolecular carbon isotope analysis has a remarkable potential for climate reconstruction. While isotope fractionation beyond leaves is currently considered to be constant, we propose significant parts of the carbon and hydrogen isotope variation in tree‐ring glucose originate in stems (precipitation‐dependent signals). As basis for follow‐up studies, we propose mechanisms introducing Δ1′, Δ2′, Δ3′, and εmet variability.
Piezo1 Promotes Osteogenesis Through CaMKII Signalling in a Rat Maxillary Expansion Model
Authors: He Zhengquan , Du Yugui , Peng Chuhan , Xu Bowen , Tang Jiayue , Liu Runxuan , Yang Kai 
Published: October 2024

ABSTRACTObjectivesRapid maxillary expansion (RME) is a widely used technique to treat maxillary transverse deficiency. Piezo1 is a cation channel that is activated by mechanical force and regulates bone formation. This study aims to elucidate the role of Piezo1 in bone remodelling during the RME process.Materials and MethodsIn this study, the periosteal‐derived stem cells (PDSCs) were cultured and stretched by the Flexcell system. The effects of Piezo1 on osteogenesis were assessed via RNA sequencing, real‐time quantitative PCR, and western blot analyses. Moreover, for in vivo analyses, the rat RME model was established. The function of Piezo1 in mid‐palatal suture bone remodelling was evaluated using micro‐CT, haematoxylin–eosin (HE) staining, and immunohistochemistry analyses.ResultsIt was revealed that under tension force, the osteogenic factors (Runt‐related transcription factor 2, Osterix, and Alkaline Phosphatase) and Ca2+/calmodulin ‐dependent protein kinase (CaMKII) were significantly enhanced in PDSCs over time. Furthermore, these were also upregulated in the RME model with the expansion of the mid‐palatal suture. However, Piezo1 inhibition by Grammostola spatulata mechanotoxin 4 downregulated the levels of these factors in the RME model.ConclusionsThis study indicated that Piezo1 is associated with the osteogenesis of PDSCs and bone remodelling in the RME process. CaMKII might also participate in this process.
Salivary microbiome and biomarker characteristics of diabetics with periodontitis
Authors: Ebersole Jeffrey L. , Kirakodu Sreenatha S. , Zhang Xiahou , Dawson Dolph , Miller Craig S. 
Published: October 2024

AbstractObjectiveTo examine the characteristics of the salivary microbiome in Type 2 diabetes mellitus (T2DM) patients with or without periodontitis.BackgroundPeriodontitis has been identified as clear sequelae of T2DM. This chronic oral disease also impacts the management of the clinical features of diabetes. The oral microbiome characteristics in T2DM with and without periodontitis, as well as the response of this oral microbiome to nonsurgical therapy have not been well described. Knowledge of key oral biological features could help address the observed poorer clinical presentation of T2DM patients.MethodsThe oral microbiome in saliva of adult cohorts periodontally healthy/non‐diabetic (non‐periodontitis; NP; n = 31), T2DM without periodontitis (DWoP; n = 32), and T2DM with periodontitis (DWP; n = 29) were characterized by microbial molecular analysis using V3–V4 sequencing and Luminex or ELISA techniques for salivary host analytes.ResultsPhyla distribution showed DWP with significantly lower levels of Firmicutes and Actinobacteria and higher levels of Fusobacteria and Spirochetes compared to the healthier groups. Approximately 10% of the detected microbial species showed significant differences in frequency and level of colonization among the DWP, DWoP, and NP samples. A subset of bacteria were significantly correlated with clinical disease features, as well as a specific repertoire of salivary analytes, in particular matrix metalloproteinase (MMP)8/MMP9, interleukin‐1ß, B‐cell activating factor, and resistin differed between the groups and were related to specific taxa. Principal component analysis that identified a majority of the DWP subjects microbiome was unique based upon an array of 27 taxa out of up to 255 detected in the saliva samples.ConclusionT2DM patients with periodontitis show unique oral microbiome and salivary analyte composition compared to diabetics or non‐diabetic persons without periodontitis. Specific members of the oral microbiome relate directly to the clinical disease features and/or salivary biomolecules in T2DM individuals.