bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Need to Calculate Target Glucose Levels When Measuring Changes in Insulin Sensitivity During Interventions for Individuals With Type 2 Diabetes
Authors: Othman Nor Azlan , Docherty Paul D. , Krebs Jeremy D. , Bell Damon A. , Chase J. Geoffrey 
Published: January 2018

Background: Physiological models that are used with dynamic test data to assess insulin sensitivity (SI) assume that the metabolic target glucose concentration ( GTARGET) is equal to fasting glucose concentration ( G0). However, recent research has implied that irregularities in G0 in diabetes may cause erroneous SI values. This study quantifies the magnitude of these errors. Methods: A clinically validated insulin/glucose model was used to calculate SI with the standard fasting assumption (SFA) G0 = GTARGET. Then GTARGET was treated as a variable in a second analysis (VGT). The outcomes were contrasted across twelve participants with established type 2 diabetes mellitus that were recruited to take part in a 24-week dietary intervention. Participants underwent three insulin-modified intravenous glucose tolerance tests (IM-IVGTT) at 0, 12, and 24 weeks. Results: SIVGT had a median value of 3.36×10−4 L·mU−1·min−1 (IQR: 2.30 – 4.95×10−4) and were significantly lower ( P < .05) than the median SISFA (6.38×10−4 L·mU−1·min−1, IQR: 4.87 – 9.39×10−4). The VGT approach generally yielded lower SI values in line with expected participant physiology and more effectively tracked changes in participant state over the 24-week trial. Calculated GTARGET values were significantly lower than G0 values (median GTARGET = 5.48 vs G0 = 7.16 mmol·L−1 P < .001) and were notably higher in individuals with longer term diabetes. Conclusions: Typical modeling approaches can overestimate SI when GTARGET does not equal G0. Hence, calculating GTARGET may enable more precise SI measurements in individuals with type 2 diabetes, and could imply a dysfunction in diabetic metabolism.
The Evolving Treatment Patterns of NCAA Division I Football Players by Orthopaedic Team Physicians Over the Past Decade, 2008-2016
Authors: Carver Trevor J. , Schrock John B. , Kraeutler Matthew J. , McCarty Eric C. 
Published: January 2018

Background: Previous studies have analyzed the treatment patterns used to manage injuries in National Collegiate Athletic Association (NCAA) Division I football players. Hypothesis: Treatment patterns used to manage injuries in NCAA Division I football players will have changed over the study period. Study Design: Descriptive epidemiology study. Level of Evidence: Level 5. Methods: The head orthopaedic team physicians for all 128 NCAA Division I football teams were asked to complete a survey containing questions regarding experience as team physician, medical coverage of the team, reimbursement issues, and treatment preferences for some of the most common injuries occurring in football players. Responses from the current survey were compared with responses from the same survey sent to NCAA Division I team physicians in 2008. Results: Responses were received from 111 (111/119, 93%) NCAA Division I orthopaedic team physicians in 2008 and 115 (115/128, 90%) orthopaedic team physicians between April 2016 and April 2017. The proportion of team physicians who prefer a patellar tendon autograft for primary anterior cruciate ligament reconstruction (ACLR) increased from 67% in 2008 to 83% in 2016 ( P < 0.001). The proportion of team physicians who perform anterior shoulder stabilization arthroscopically increased from 69% in 2008 to 93% in 2016 ( P < 0.0001). Of team physicians who perform surgery for grade III posterior cruciate ligament (PCL) injuries, the proportion who use the arthroscopic single-bundle technique increased from 49% in 2008 to 83% in 2016 ( P < 0.0001). The proportion of team physicians who use Toradol injections prior to a game to help with nagging injuries decreased from 62% in 2008 to 26% in 2016 ( P < 0.0001). Conclusion: Orthopaedic physicians changed their injury treatment preferences for NCAA Division I football players over the study period. In particular, physicians have changed their preferred techniques for ACLR, anterior shoulder stabilization, and PCL reconstruction. Physicians have also become more conservative with pregame Toradol injections. Clinical Relevance: These opinions may help guide treatment decisions and lead to better care of all athletes.
Glycophorin-C sialylation regulates Lu/BCAM adhesive capacity during erythrocyte aging
Authors: Klei T. R. L. , de Back D. Z. , Asif P. J. , Verkuijlen P. J. J. H. , Veldthuis M. , Ligthart P. C. , Berghuis J. , Clifford E. , Beuger B. M. , van den Berg T. K. , van Zwieten R. , El Nemer W. , van Bruggen R. 
Published: January 2018

Key PointsThe Lu/BCAM adhesion molecule is gradually activated during erythrocyte aging due to loss of sialic acid on glycophorin-C. Upon activation, Lu/BCAM engages a sialic acid–dependent interaction with the extracellular matrix protein laminin-α5.
TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children
Authors: Qian Maoxiang , Cao Xueyuan , Devidas Meenakshi , Yang Wenjian , Cheng Cheng , Dai Yunfeng , Carroll Andrew , Heerema Nyla A. , Zhang Hui , Moriyama Takaya , Gastier-Foster Julie M. , Xu Heng , Raetz Elizabeth , Larsen Eric , Winick Naomi , Bowman W. Paul , Martin Paul L. , Mardis Elaine R. , Fulton Robert , Zambetti Gerard , Borowitz Michael , Wood Brent , Nichols Kim E. , Carroll William L. , Pui Ching-Hon , Mullighan Charles G. , Evans William E. , Hunger Stephen P. , Relling Mary V. , Loh Mignon L. , Yang Jun J. 
Published: January 2018

Purpose Germline TP53 variation is the genetic basis of Li-Fraumeni syndrome, a highly penetrant cancer predisposition condition. Recent reports of germline TP53 variants in childhood hypodiploid acute lymphoblastic leukemia (ALL) suggest that this type of leukemia is another manifestation of Li-Fraumeni syndrome; however, the pattern, prevalence, and clinical relevance of TP53 variants in childhood ALL remain unknown. Patients and Methods Targeted sequencing of TP53 coding regions was performed in 3,801 children from the Children’s Oncology Group frontline ALL clinical trials, AALL0232 and P9900. TP53 variant pathogenicity was evaluated according to experimentally determined transcriptional activity, in silico prediction of damaging effects, and prevalence in non-ALL control populations. TP53 variants were analyzed for their association with ALL presenting features and treatment outcomes. Results We identified 49 unique nonsilent rare TP53 coding variants in 77 (2.0%) of 3,801 patients sequenced, of which 22 variants were classified as pathogenic. TP53 pathogenic variants were significantly over-represented in ALL compared with non-ALL controls (odds ratio, 5.2; P < .001). Children with TP53 pathogenic variants were significantly older at ALL diagnosis (median age, 15.5 years v 7.3 years; P < .001) and were more likely to have hypodiploid ALL (65.4% v 1.2%; P < .001). Carrying germline TP53 pathogenic variants was associated with inferior event-free survival and overall survival (hazard ratio, 4.2 and 3.9; P < .001 and .001, respectively). In particular, children with TP53 pathogenic variants were at a dramatically higher risk of second cancers than those without pathogenic variants, with 5-year cumulative incidence of 25.1% and 0.7% ( P < .001), respectively. Conclusion Loss-of-function germline TP53 variants predispose children to ALL and to adverse treatment outcomes with ALL therapy, particularly the risk of second malignant neoplasms.
Is there any relationship between adc values of diffusion-weighted imaging and the histopathological prognostic factors of invasive ductal carcinoma?
Authors: Aydin Hale , Guner Bahar , Esen Bostanci Isil , Bulut Zarife Melda , Aribas Bilgin Kadri , Dogan Lutfi , Gulcelik Mehmet Ali 
Published: January 2018

Objective:
MRI is being used increasingly as a modality that can provide important information about breast cancer. Diffusion-weighted imaging (DWI) is an imaging technique from which apparent diffusion coefficient (ADC) values can be calculated in addition to obtaining important structural information which cannot be obtained from other imaging studies. We did not find any significant relationships between ADC values and prognostic factors, but did provide some explanations for conflicting results in the literature.

Methods:
The ADC results of 61 females with invasive ductal carcinomas were evaluated. DWI was performed and ADC values were calculated from the area in which restriction of diffusion was the highest in ADC mapping. B value was 500 and region of interest (ROI) was designated between 49 and 100 mm2. Calculations were performed automatically by the device. Tissue samples were obtained for prognostic factor evaluation. The relationships between ADC and prognostic factors were investigated. Comparisons between groups were made with one-way ANOVA and Kruskal Wallis test. Pairwise comparisons were made with Dunn’s test. Analyses of categorical variables were made with Chi-square test.

Results:
We found a weak negative correlation between ADC and Ki-67 values (r = −0.279; p = 0.029). When we compared ADC values in regard to tumour type, we found no significant differences for tumour grade, Ki-67 positivity, estrogen receptor positivity, progesterone receptor positivity, C-erb B2, lymphovascular invasion and ductal carcinoma in situ or lobular carcinoma in situ component. On a side note, we found that mean ADC values decreased as tumour grade increased; however, this was not statistically significant.

Conclusion:
The literature contains studies that report conflicting results which may be caused by differences in B values, ROI area and magnetic field strength. Multicentre studies and systematic reviews of these findings may produce crucial data for the use of DWI in breast cancer.

Advances in knowledge:
To determine if any significant relationship exists between DWI findings and prognostic factors of breast cancer.
Design of a professional development programme for palliative care nurses (Part Two)
Authors: Yates Patsy , Clinton Michael , Hart Gail 
Published: January 2018

Yates et al (1996) provided a review of the literature on educational approaches to improving psychosocial care of terminally ill patients and their families and suggested that there was an urgent need for innovation in this area. A programme of professional development currently being offered to 181 palliative care nurses in Queensland, Australia, was also described. This paper presents research in progress evaluating this programme which involves use of a quasi-experimental pre-post test design. It also includes process and outcome measures to assess effectiveness in improving the participant's ability to provide psychosocial care to patients and families.
General nurses' perceptions of palliative care
Authors: Holmes Susan , Pope Susan , Lamond Dawn 
Published: January 2018

Although considerable progress has been made in treating cancer, it is suggested that, even at diagnosis, attempts at cure may sometimes be unrealistic. As a result, many patients may require palliative care on general hospital wards, and how general nurses understand or interpret the goals of palliative care may determine, at least in part, the care they provide. This qualitative, exploratory study attempted to develop an understanding of the perceptions of general nurses towards palliative care. Findings indicate that this sample of nurses focused primarily on the disease and that which the patient had ‘lost’, regarding him/her not as a living person but as a dying patient. The nurses' role is seen to be that of ‘taking over’ all activities for the patient, so as to reduce suffering. The importance of maintaining quality of life and the need to respect patients' wishes are recognised, although it appears that nurses often assume that they ‘know’ what is best. Although the nurses exhibited considerable commitment to providing the best possible care, their predominant perception of the patient as dying determined the interventions selected. This preoccupation with dying may prevent them from helping the patient to live a full life until the time of death.
The trajectory of Afterimage
Authors: Helm-Grovas Nicolas 
Published: January 2018

Abstract
This article charts the history of the British film magazine Afterimage, from its prehistory at the University of Essex in the late 1960s to its final issue in 1987. I trace Afterimage’s presentation of various interlocking strands of experimental and political cinema, the mutations in its theoretical and aesthetic postures, and the imbrication of the journal and its editors – Simon Field, Peter Sainsbury, and later Ian Christie and Michael O’Pray – in alternative, independent practices of film-making, programming, distribution and publishing. Via Afterimage, I sketch the history of a larger radical film culture in Britain that emerged in the late 1960s but had largely dissipated as the 1980s drew to a close.
Spotlight on Hull: Time-based art on the margins
Authors: Wilczek Emily 
Published: January 2018

Abstract
In 2017 Hull has been designated UK City of Culture, a bid it won on the promise of ‘coming out of the shadows’. But in its recent past Hull has been very much in the spotlight in the area of time-based art. This article looks at the emergence of this activity in Hull in the late twentieth century, and in particular the role of the artist-led organization Hull Time Based Arts (HTBA). Examples of HTBA’s programme are discussed in order to understand the significance of this organization and in particular its programming of political, formal and community specific artworks. The wider issues of community, funding and arts education are also discussed as crucial factors underpinning artist-led activity in a city.
Discoveries in the biscuit tin: The role of archives and collections in the history of artists’ moving image in Scotland
Authors: Neely Sarah 
Published: January 2018

Abstract
This article examines the situation of artists’ moving image works within existing archives and collections. With a specific focus on the archiving of experimental film in Scotland, the article makes use of existing research in the field, while drawing from recent interviews with artists, curators and archivists in Scotland, Ireland and Norway.
History, landscape, nation: British independent film and video in the 1970s and 1980s
Authors: Perry Colin 
Published: January 2018

Abstract
This article examines uses of history in British independent film and video in the 1970s and 1980s, looking at ways in which radical pasts were called on to foster struggle in the present. In tracing the influence of New Left cultural historians on independent film and video, and television, during these two decades, this article also suggests ways in which the nation is figured, contested and re-drawn in specific works by Kevin Brownlow and Andrew Mollo, Phil Mulloy and Black Audio Film Collective. A rich and diverse framework of leftist historical discourse is outlined, suggesting that the exploration of a socialized landscape (the city as well as the country) played on and renegotiated existing myths and tropes of Britishness, identity and belonging. This article also fills a gap in existing accounts of radical film’s uses of history, going beyond valedictory accounts of modernist historiography to assert the vitality of a complex counterpublic discourse. It concludes with a reflection on problems in the depiction and imagination of the past today.
The Performance of Trauma in Moving Image Art, Dirk de Bruyn (2014)
Authors: Walsh Maria 
Published: January 2018

Abstract
Cambridge and Newcastle upon Tyne: Cambridge Scholars Publishing, 245pp, ISBN: 9781443860536, hardback, £47.99
London: Palgrave Macmillan, 200pp, ISBN: 9781137361363, hardback, £60
Unfamiliarity and difference: The challenges of supporting arts activity in a new medium
Authors: Knight Julia 
Published: January 2018

Abstract
Video technology had a relatively brief lifespan, but like digital it was once a new media technology. This article revisits the newness of video in the late 1970s and early 1980s to explore the challenges it posed for supporting and promoting video art in Britain – including developing and funding a video infrastructure, creating an identity for video art and sustaining a video specific identity in the face of technological and social change. Aspects of this history resonate with the more recent history of digital technology and the article concludes that video can be understood as digital’s forerunner.
In search of lost time: Cordelia Swann, the 1980s and the use of history
Authors: Holdsworth Claire M. 
Published: January 2018

Abstract
This article undertakes close readings of two works by Cordelia Swann as a means of reappraising some cultural touchstones, in particular, discussion of ‘New Romantic’ film-making in British film and video during the 1980s. It examines how notions of the old and the new are displaced within Swann’s practice, altering understanding of much earlier, more distant times. By foregrounding her use of multi-source imagery and in later analysis, sound and the ‘voice’ – her personal, striking subjects create shifting conceptions of time and selfhood that affect perspective of this decade and encourage critical engagement with historiography within the moving image.
From Reel to Real – an epilogue: Feminist politics and materiality at the London Filmmakers’ Co-operative
Authors: Jacquin Maud 
Published: January 2018

Abstract
This article is an a posteriori reflection on the film programme entitled ‘From Reel To Real: Women, Feminism and the London Filmmakers’ Co-operative’ that I curated in the context of the 50th anniversary of the LFMC. This programme, which took place at Tate Modern and Tate Britain in September 2016, gathered more than 40 films – both single screen and expanded – by 25 film-makers from different generations. In addition to attempting to situate the unique contribution of the women film-makers associated with the LFMC in relation to both experimental and feminist film, I argue that the LFMC’s particular relationship with filmic materiality led the women film-makers to apprehend cinematic spectatorship but also subjectivity, the body or one’s relationship with the other in ways that can be productively explored in the light of recent developments in both film and feminist theory.
Identification of The Determinants of Enterpreneurial Success: A Multidimensional Framework
Authors: Vidyatmoko Dyan , Hastuti Pudji 
Published: January 2018

<p class="Body-1"><span lang="EN-US">Although the academics have discussed various topics related to the factors that influence the entrepreneurial success, but there are still many differences about which factors are very important. The most important characteristics of successful entrepreneurs often become a big question. It is reasonable due to the increasing diversity of approaches used in a variety of disciplines on the study of entrepreneur. <span class="longtext"><span>There were many literatures that discussed a variety of variables affecting the success of entrepreneurs, especially in developed countries. In an effort to fill the lack of research on the success of entrepreneurs in developing countries, especially in Indonesia</span></span></span><span class="longtext"><span lang="IN">,</span></span><span class="longtext"><span lang="IN">t</span></span><span class="longtext"><span lang="EN-US">his paper tries to propose a theoretical framework to examine factors that affect the success of entrepreneurs,the proposed framework uses a multidimensional analysis of success factors whereby three factors are discussed simultaneously. These include the entrepreneur, the entrepreneurial firm and the external environment. Success is represented by three indicators which consist of employment growth, profitability and survival. This framework is the development of theoretical framework proposed by Kiggundu, and Lussier and Halabi. Compared to </span></span><span lang="EN-US">Kiggundu and Lussier and Halabi model, the proposed approach is expected to provide a comprehensive analysis of the factors affecting the success of entrepreneur in Indonesia. This multidimensional approach can illustrate the scope of various entrepreneurial phenomena in Indonesia.In addition, using the analytical technique to be used to test the relationship and the influence of independent variables, the concept of this framework will produce determinant variables and eliminate the variables that are not relevant<span class="longtext"><span>The study will use </span></span>Structural Equation Model. It is relevant and useful both from the academic and practical points of view and has practical implications for policymakers in terms of conceptualizing and operationalizing factors affecting the success of entrepreneurs in Indonesia.</span></p>
Management of Indonesia ICT Business Incubators: Administrators’ Compared to Tenants’ Perspecive
Authors: Sirait Emyana Ruth Eritha , Wildana Faiq 
Published: January 2018

<p>Business incubation is one of entrepreneurship development methods believed to have advantages compared with other SME development patterns. The model used in managing the business incubators is influenced by the business focus of the participants/tenants. In managing the ICT business incubators, there are some key factors slightly different from the management of others. However, the legal rules and standards for organizing various types of incubators are still equated. It is concerned that there will be some misunderstandings/misleading from the administrators or managers in providing their services, so that the process fails to reach its main objectives. This study has surveyed some managers of ICT incubators to get their perspectives about the dominant aspects among 8-S mandatory services by using Analytical Hierarchy Process, and also some tenants about their satisfaction to incubators services. The result is then reviewed based on ICT product and business characteristics.</p><p> </p>Keywords: ICT Business Incubators, Management, Analytical Hierarchy Process, Customer Development Model.
Mobilizing Science, Technology and Innovation (STI) for Socio-Economic Development: The Experience of Malaysia
Authors: Thiruchelvam Kanagasundram 
Published: January 2018

<div><p>Malaysia has achieved remarkable economic growth for most parts of its history but is finding itself dogged by weak technological dynamism due to structural features of the economy as well as less than satisfactory proficiency in science, technology and innovation (STI). Despite massive investments in creating STI infrastructure, education, physical infrastructure and incentives to support technology upgrading, the stark reality is that the country continues to lag behind the successful latecomers. This paper presents a brief overview on Malaysia’s STI achievements, salient features of the nation’s national innovation system (NIS), the key challenges of its NIS and some recommendations on moving forward. The central theme of the paper is that success in STI is not automatic. It must be made to happen through effective policies promoting innovation as well as innovations in policy-making itself.</p><p> </p><p><span style="text-decoration: underline;">Key words</span>: Malaysia; national innovation system; STI; innovation; policy making</p></div>