bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone involvement: Histopathological evidence for endoscopic management of sinonasal inverted papilloma
Authors: Liang Na , Huang Zhenxiao , Liu Honggang , Xian Junfang , Huang Qian , Zhou Bing 
Published: July 2017

ObjectiveThe aim of this study is to provide histopathological evidence for a better understanding of the excision of bone underlying tumor.Study DesignRetrospective study.MethodsThirty patients with histopathological diagnosis of sinonasal inverted papilloma (SIP) were enrolled. All patients underwent preoperative radiography to define the tumor location. The primary tumor and underlying bone, removed during endoscopic surgery, were examined under microscope.ResultsTwenty‐five of 30 specimens exhibited bony hyperostosis on computed tomography (CT) images, and 12 of 30 specimens showed evidence of bony lamellar erosion. Both coexisted in 11 cases. Half of the relapse cases (8 of 16) presented bone discontinuity on CT, which indicates a higher propensity for bone involvement when compared with primary SIP. On histopathology, 26 cases presented hyperostosis and 11 cases showed bone invasion. In total, 90% of cases covered both. Sixteen cases showed a growing tendency of inflammatory cells infiltration.ConclusionHistopathological evidence of bone involvement indicates the importance of removal of the underlying bone at the time of endoscopic tumor resection. We hypothesized that bone involvement including bone invasion and osteogenesis may be induced by the tumor, and any microscopic lesion in the bony crevices probably indicates recurrence of SIP. Furthermore, infiltration of inflammatory cells may facilitate bone involvement and cause recurrence.Level of EvidenceNA.Laryngoscope, 127:2703–2708, 2017
Impact of sinonasal disease on depression, sleep duration, and productivity among adults in the United States
Authors: Zhou Sheng , Hur Kevin , Shen Jasper , Wrobel Bozena 
Published: July 2017

ObjectiveExamine the relationship between depression symptoms and sinonasal inflammatory diseases, and investigate health disparities associated with allergic rhinitis (AR) and sinusitis in the United States.Study DesignCross‐sectional analysis of 2014 National Health Interview Survey (NHIS) data.MethodsAdult cases of AR and sinusitis were extracted from the 2014 NHIS in addition to demographic, socioeconomic, and related depressive symptom data. The dataset was analyzed with chi‐square, t‐tests, and multivariate regression.ResultsThere were 19.1 ± 1.1 million adult AR cases and 29.4 ± 1.4 million adult sinusitis cases. Of these, 20.6% and 22.0% reported depression symptoms in the past 12 months for those with AR or sinusitis, respectively. Both diseases were also associated with significantly fewer mean hours of sleep a night (AR: 7.02 vs. 7.14, P < 0.01; Sinusitis: 6.98 vs. 7.14, P < 0.01) and greater mean days of work missed (AR: 4.60 vs. 3.62, P < 0.01; Sinusitis: 5.87 vs. 3.41; P < 0.01). On multivariate analysis, the prevalence of AR and sinusitis was significantly higher among men, Caucasians, older adults, the more educated, and adults with depression symptoms. Only the prevalence of sinusitis varied depending on income and geography.ConclusionAllergic rhinitis and sinusitis are associated with an increased likelihood of depressive symptoms, shorter sleep duration, and more workdays lost. The prevalence of both are influenced by age, sex, race/ethnicity, and education level. Targeted initiatives should be developed to address these health disparities and comorbidities associated with inflammatory sinonasal disease.Level of Evidence4.
Progressive resistance training in head and neck cancer patients undergoing concomitant chemoradiotherapy
Authors: Lonkvist Camilla K. , Vinther Anders , Zerahn Bo , Rosenbom Eva , Deshmukh Atul S. , Hojman Pernille , Gehl Julie 
Published: July 2017

ObjectivesPatients with head and neck squamous cell carcinoma undergoing concomitant chemoradiotherapy (CCRT) frequently experience weight loss, especially loss of lean body mass (LBM), and reduced functional performance. This study investigated whether a 12‐week hospital‐based progressive resistance training (PRT) program during CCRT is feasible in the clinical setting before planning initiation of a larger randomized study which is the long‐term goal.Study designProspective pilot study.MethodsTwelve patients receiving CCRT were planned to attend a 12‐week PRT program. Primary endpoint was feasibility measured as attendance to training sessions. Secondary endpoints included changes in functional performance, muscle strength, and body composition measured by Dual‐energy X‐ray Absorptiometry (DXA) scans. Furthermore, sarcomeric protein content, pentose phosphate pathway (PPP) activity, and glycolysis were determined in muscle biopsies.ResultsTwelve patients with p16 positive oropharyngeal cancer were enrolled. The primary endpoint was met with 9 of the 12 patients completing at least 25 of 36 planned training sessions. The mean attendance rate was 77%. Functional performance was maintained during the treatment period and increased during follow‐up (p < 0.01). Strength was regained after an initial dip during treatment, paralleling responses in LBM and sarcomeric protein content. LBM began to increase immediately after treatment. The PPP was upregulated after the treatment period, whilst glycolysis remained unchanged. No adverse events were related to PRT and in questionnaires, patients emphasized the social and psychological benefits of attendance.ConclusionProgressive resistance training is feasible and safe during CCRT for head and neck cancer, and is associated with high patient satisfaction.Level of Evidence2C.
Verbal working memory and inhibition‐concentration in adults with cochlear implants
Authors: Moberly Aaron C. , Houston Derek M. , Harris Michael S. , Adunka Oliver F. , Castellanos Irina 
Published: July 2017

ObjectivesNeurocognitive functions contribute to speech recognition in postlingual adults with cochlear implants (CIs). In particular, better verbal working memory (WM) on modality‐specific (auditory) WM tasks predicts better speech recognition. It remains unclear, however, whether this association can be attributed to basic underlying modality‐general neurocognitive functions, or whether it is solely a result of the degraded nature of auditory signals delivered by the CI. Three hypotheses were tested: 1) Both modality‐specific and modality‐general tasks of verbal WM would predict scores of sentence recognition in speech‐shaped noise; 2) Basic modality‐general neurocognitive functions of controlled fluency and inhibition‐concentration would predict both modality‐specific and modality‐general verbal WM; and 3) Scores on both tasks of verbal WM would mediate the effects of more basic neurocognitive functions on sentence recognition.Study DesignCross‐sectional study of 30 postlingual adults with CIs and thirty age‐matched normal‐hearing (NH) controls.Materials and MethodsParticipants were tested for sentence recognition in speech‐shaped noise, along with verbal WM using a modality‐general task (Reading Span) and an auditory modality‐specific task (Listening Span). Participants were also assessed for controlled fluency and inhibition‐concentration abilities.ResultsFor CI users only, Listening Span scores predicted sentence recognition, and Listening Span scores mediated the effects of inhibition‐concentration on speech recognition. Scores on Reading Span were not related to sentence recognition for either group.ConclusionInhibition‐concentration skills play an important role in CI users' sentence recognition skills, with effects mediated by modality‐specific verbal WM. Further studies will examine inhibition‐concentration and WM skills as novel targets for clinical intervention.Level of Evidence4.
Plasma thiobarbituric acid reactive substances (TBARS) in young adults: Obesity increases fasting levels only in men whereas glucose ingestion, and not protein or lipid intake, increases postprandial concentrations regardless of sex and obesity
Authors: Montes‐Nieto Rafael , Insenser María , Murri Mora , Fernández‐Durán Elena , Ojeda‐Ojeda Miriam , Martínez‐García María Ángeles , Luque‐Ramírez Manuel , Escobar‐Morreale Héctor F. 
Published: July 2017

ScopeOxidative stress and damage participate in the pathophysiology of obesity and its metabolic complications. We studied the influence of sex, obesity, and ingestion of different macronutrients on fasting and postprandial thiobarbituric acid reactive substances (TBARS), which can be considered as an index of lipid peroxidation and oxidative damage.Methods and resultsWe studied 19 men and 17 women, out of whom nine men and eight women had obesity. We collected blood samples in the fasting state and, on alternate days, following the ingestion of 300 kcal in the form of glucose, lipids, or proteins. Fasting TBARS concentrations correlated with waist circumference and were increased in obese men compared with nonobese men. This increase was not, however, observed in women. TBARS concentrations showed a marked increase following the ingestion of glucose in parallel to the increase in plasma glucose when considering all subjects as a whole, but did not increase after the oral intake of lipids and proteins.ConclusionPlasma TBARS concentrations are increased in the fasting state only in obese men in association with abdominal adiposity, and increases markedly after the ingestion of glucose, but not after oral intake of lipids and proteins, regardless of sex and obesity.
Prospective motion correction using coil‐mounted cameras: Cross‐calibration considerations
Authors: Maclaren Julian , Aksoy Murat , Ooi Melvyn B. , Zahneisen Benjamin , Bammer Roland 
Published: July 2017

PurposeOptical prospective motion correction substantially reduces sensitivity to motion in neuroimaging of human subjects. However, a major barrier to clinical deployment has been the time‐consuming cross‐calibration between the camera and MRI scanner reference frames. This work addresses this challenge.MethodsA single camera was mounted onto the head coil for tracking head motion. Two new methods were developed: (1) a rapid calibration method for camera‐to‐scanner cross‐calibration using a custom‐made tool incorporating wireless active markers, and (2) a calibration adjustment method to compensate for table motion between scans. Both methods were tested at 1.5T and 3T in vivo. Simulations were performed to determine the required mechanical tolerance for repositioning of the camera.ResultsThe rapid calibration method is completed in a short (<30 s) scan, which is carried out only once per installation. The calibration adjustment method requires no extra scan time and runs automatically whenever the system is used. The mechanical tolerance analysis indicates that most motion (90% reduction in voxel displacement) could be corrected even with far larger camera repositioning errors than are observed in practice.ConclusionThe methods presented here allow calibration of sufficient quality to be carried out and maintained with no additional technologist workload. Magn Reson Med 79:1911–1921, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Homotopy approach for random eigenvalue problem
Authors: Huang Bin , Zhang Heng , Phoon Kok‐Kwang 
Published: July 2017

AbstractA novel approach, referred to as the homotopy stochastic finite element method, is proposed to solve the eigenvalue problem of a structure associated with some amount of uncertainty based on the homotopy analysis method. For this approach, an infinite multivariate series of the involved random variables is proposed to express the random eigenvalue or even a random eigenvector. The coefficients of the multivariate series are determined using the homotopy analysis method. The convergence domain of the derived series is greatly expanded compared with the Taylor series due to the use of an approach function of the parameter h. Therefore, the proposed method is not limited to random parameters with small fluctuation. However, in practice, only single‐variable and double‐variable approximations are employed to simplify the calculation. The numerical examples show that with a suitable choice of the auxiliary parameter h, the suggested approximations can produce very accurate results and require reduced or similar computational efforts compared with the existing methods.
Triple shape memory effect of foamed natural Eucommia ulmoides gum/high‐density polyethylene composites
Authors: Wang Yan , Xia Lin , Xin Zhenxiang 
Published: July 2017

This paper proposes a new technique for the preparation of foamed Eucommia ulmoides gum (EUG)/high‐density polyethylene (HDPE) shape memory composites and establishes the relationship between structures and properties in foamed shape memory composites. Eucommia ulmoides gum/HDPE shape memory composites are designed to memorize 2 temporary shapes by exploiting the different melting points of the 2 phases; the triple shape memory effect in the composites is investigated via mechanical measurements, thermal analysis, and shape memory behavior analysis. The results show that HDPE phase enables the composites to effectively memorize the first temporary shape and EUG phase contributes the second temporary shape. When the ratios of EUG and HDPE were 80/20 and 70/ 30, the composite exhibited satisfactory shape memory behavior with favorable shape fixity ratio and shape recovery ratio, in addition to excellent mechanical properties (tensile strength of 15 MPa, tear strength above 51 KN/m, and foam porosity of about 11%).
Energy Migration Upconversion in Ce(III)‐Doped Heterogeneous Core−Shell−Shell Nanoparticles
Authors: Chen Xian , Jin Limin , Sun Tianying , Kong Wei , Yu Siu Fung , Wang Feng 
Published: July 2017

AbstractOne major challenge in upconversion research is to develop new materials and structures to expand the emission spectrum. Herein, a heterogeneous core−shell−shell nanostructure of NaYbF4:Gd/Tm@NaGdF4@CaF2:Ce is developed to realize efficient photon upconversion in Ce3+ ions through a Gd‐mediated energy migration process. The design takes advantage of CaF2 host that reduces the 4f–5d excitation frequency of Ce3+ to match the emission line of Gd3+. Meanwhile, CaF2 is isostructural with NaGdF4 and can form a continuous crystalline lattice with the core layer. As a result, effective Yb3+ → Tm3+ → Gd3+ → Ce3+ energy transfer can be established in a single nanoparticle. This effect enables efficient ultraviolet emission of Ce3+ following near infrared excitation into the core layer. The Ce3+ upconversion emission achieved in the core−shell−shell nanoparticles features broad bandwidth and long lifetime, which offers exciting opportunities of realizing tunable lasing emissions in the ultraviolet spectral region.
Stress analysis of functional gradient strip due to transient thermal heat
Authors: Zou Guangping , Dergachova Nadiia 
Published: July 2017

AbstractThe work is mainly focuses on the analysis of thermal gradients and its effect on thermal stresses in FGM (functional gradient material) grading‐strip made up of TiC‐Ni due to thermal heat with different rate: thermal shock, transient exponential and linear heat. In this paper, asymptotic analytical solution for exponential and linear heat will be investigated. Few models of material grading are considered: (a) models which depend on different volume content of TiC and (b) models with homogeneous layers. Thermal and mechanical properties of the material are assumed different along axis. It is assumed that Poisson's ratio and Young's modulus varies exponentially with the coordinate of the strip. The dependence on different material property idealizations is also investigated. As well for research maximum and minimal thermal stresses in paper compared laminated non‐FGM and FGM strip. The maximum tensile stress obtained for FGM case. At the same time compressive stresses near heated surface for two‐layered strip lager then for three‐layered and less or absent for FGM strip. Heating/cooling opposite edge to thermal shocked ones leads to increase/decrease compressive stress in metal phase part in FGM and layered strip. At the beginning of heat the differences in compressive stress for thermal shock and exponential heat could differ in ten times. Compressive stress in linear heat case increase from beginning and stay stable as maximum from three heat cases as long as edge heat up to maximum temperature. The results obtained in this research paper allow us to analyze the validity of this method and to understand principles of thermal behavior on FGM‐strip in a case of different conditions and different heat transfer rate.
Well‐posed dual‐phase‐lag model of a thermoelastic dipolar body
Authors: Marin Marin , Broadbridge Philip , Öchsner Andreas 
Published: July 2017

AbstractWe consider a time differential model for dual‐phase‐lag thermoelastic dipolar material. For the heat flux with dual‐phase‐lag we introduce a time differential equation to describe the thermal effects, and this is coupled with elastic deformation. Some qualitative results on solutions of the mixed initial boundary value problem, associated with this model, are obtained under mild constitutive restrictions. We will deduce an identity of Lagrange type and will use a conservation law in order to prove the uniqueness of solution, whereas the result of continuous dependence of solution is established by using a Gronwall type inequality and a conservation law.
Retrosternal Reconstruction Can be a Risk Factor for Upper Extremity Deep Vein Thrombosis After Esophagectomy
Authors: Takahashi Takamasa , Fukaya Masahide , Miyata Kazushi , Sakatoku Yayoi , Nagino Masato 
Published: July 2017

AbstractBackgroundUpper extremity deep vein thrombosis (UEDVT) is a rare but important complication because it can cause pulmonary embolism. The aim of this study was to investigate the incidence of UEDVT after esophagectomy and the risk factors related to UEDVT.MethodsThis study included 88 patients who underwent esophagectomy with retrosternal or posterior mediastinal reconstruction using gastric tube. The incidence of UEDVT and the diameter of left brachiocephalic vein were measured using postoperative contrast‐enhanced computed tomography (CT). (a) The distance from sternum to brachiocephalic artery and (b) the distance from sternum to vertebra were measured by preoperative CT, and the ratio of (a) to (b) was defined as the width of the retrosternal space.ResultsAmong the patients, 14 (15.9%) suffered from UEDVT. All UEDVTs were found in left‐side upper extremity deep veins. Twelve of the 14 patients (85.7%) underwent retrosternal reconstruction. In a multivariate analysis, retrosternal reconstruction was an independent risk factor for UEDVT (odds ratio 5.48). The diameter of the left brachiocephalic vein in patients with retrosternal reconstruction was significantly smaller than that in patients with posterior mediastinal reconstruction (4.3 vs 6.9 mm; P < 0.001) due to compression of left brachiocephalic vein by the gastric tube. Among patients with retrosternal reconstruction, the width of the retrosternal space in patients with UEDVT was significantly smaller than that in patients without UEDVT (0.21 vs 0.27; P = 0.001).ConclusionRetrosternal reconstruction can be a risk factor for UEDVT. In patients with small width of the retrosternal space, retrosternal reconstruction might be inappropriate.
Cardiac complications of congenital disorders of glycosylation (CDG): a systematic review of the literature
Authors: Marques‐da‐Silva D. , Francisco R. , Webster D. , dos Reis Ferreira V. , Jaeken J. , Pulinilkunnil T. 
Published: July 2017

AbstractCongenital disorders of glycosylation (CDG) are inborn errors of metabolism due to protein and lipid hypoglycosylation. This rapidly growing family of genetic diseases comprises 103 CDG types, with a broad phenotypic diversity ranging from mild to severe poly‐organ ‐system dysfunction. This literature review summarizes cardiac involvement, reported in 20% of CDG. CDG with cardiac involvement were divided according to the associated type of glycosylation: N‐glycosylation, O‐glycosylation, dolichol synthesis, glycosylphosphatidylinositol (GPI)‐anchor biosynthesis, COG complex, V‐ATPase complex, and other glycosylation pathways. The aim of this review was to document and interpret the incidence of heart disease in CDG patients. Heart disorders were grouped into cardiomyopathies, structural defects, and arrhythmogenic disorders. This work may contribute to improved early management of cardiac complications in CDG.
Loss of sirtuin 4 leads to elevated glucose‐ and leucine‐stimulated insulin levels and accelerated age‐induced insulin resistance in multiple murine genetic backgrounds
Authors: Huynh Frank K. , Hu Xiaoke , Lin Zhihong , Johnson James D. , Hirschey Matthew D. 
Published: July 2017

AbstractSeveral inherited metabolic disorders are associated with an accumulation of reactive acyl‐CoA metabolites that can non‐enzymatically react with lysine residues to modify proteins. While the role of acetylation is well‐studied, the pathophysiological relevance of more recently discovered acyl modifications, including those found in inherited metabolic disorders, warrants further investigation. We recently showed that sirtuin 4 (SIRT4) removes glutaryl, 3‐hydroxy‐3‐methylglutaryl, 3‐methylglutaryl, and 3‐methylglutaconyl modifications from lysine residues. Thus, we used SIRT4 knockout mice, which can accumulate these novel post‐translational modifications, as a model to investigate their physiological relevance. Since SIRT4 is localized to mitochondria and previous reports have shown SIRT4 influences metabolism, we thoroughly characterized glucose and lipid metabolism in male and female SIRT4KO mice across different genetic backgrounds. While only minor perturbations in overall lipid metabolism were observed, we found SIRT4KO mice consistently had elevated glucose‐ and leucine‐stimulated insulin levels in vivo and developed accelerated age‐induced insulin resistance. Importantly, elevated leucine‐stimulated insulin levels in SIRT4KO mice were dependent upon genetic background since SIRT4KO mice on a C57BL/6NJ genetic background had elevated leucine‐stimulated insulin levels but not SIRT4KO mice on the C57BL/6J background. Taken together, the data suggest that accumulation of acyl modifications on proteins in inherited metabolic disorders may contribute to the overall metabolic dysfunction seen in these patients.