bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing Automatic CME Detections in Multiple LASCO and SECCHI Catalogs
Authors: Hess Phillip , Colaninno Robin C. 
Published: February 2017

Abstract
With the creation of numerous automatic detection algorithms, a number of different catalogs of coronal mass ejections (CMEs) spanning the entirety of the Solar and Heliospheric Observatory (SOHO) Large Angle Spectrometric Coronagraph (LASCO) mission have been created. Some of these catalogs have been further expanded for use on data from the Solar Terrestrial Earth Observatory (STEREO) Sun Earth Connection Coronal and Heliospheric Investigation (SECCHI) as well. We compare the results from different automatic detection catalogs (Solar Eruption Event Detection System (SEEDS), Computer Aided CME Tracking (CACTus), and Coronal Image Processing (CORIMP)) to ensure the consistency of detections in each. Over the entire span of the LASCO catalogs, the automatic catalogs are well correlated with one another, to a level greater than 0.88. Focusing on just periods of higher activity, these correlations remain above 0.7. We establish the difficulty in comparing detections over the course of LASCO observations due to the change in the instrument image cadence in 2010. Without adjusting catalogs for the cadence, CME detection rates show a large spike in cycle 24, despite a notable drop in other indices of solar activity. The output from SEEDS, using a consistent image cadence, shows that the CME rate has not significantly changed relative to sunspot number in cycle 24. These data, and mass calculations from CORIMP, lead us to conclude that any apparent increase in CME rate is a result of the change in cadence. We study detection characteristics of CMEs, discussing potential physical changes in events between cycles 23 and 24. We establish that, for detected CMEs, physical parameters can also be sensitive to the cadence.
SETIBURST: A Robotic, Commensal, Realtime Multi-science Backend for the Arecibo Telescope
Authors: Chennamangalam Jayanth , MacMahon David , Cobb Jeff , Karastergiou Aris , Siemion Andrew P. V. , Rajwade Kaustubh , Armour Wes , Gajjar Vishal , Lorimer Duncan R. , McLaughlin Maura A. , Werthimer Dan , Williams Christopher 
Published: February 2017

Abstract
Radio astronomy has traditionally depended on observatories allocating time to observers for exclusive use of their telescopes. The disadvantage of this scheme is that the data thus collected is rarely used for other astronomy applications, and in many cases, is unsuitable. For example, properly calibrated pulsar search data can, with some reduction, be used for spectral line surveys. A backend that supports plugging in multiple applications to a telescope to perform commensal data analysis will vastly increase the science throughput of the facility. In this paper, we present “SETIBURST,” a robotic, commensal, realtime multi-science backend for the 305 m Arecibo Telescope. The system uses the 1.4 GHz, seven-beam Arecibo L-band Feed Array (ALFA) receiver whenever it is operated. SETIBURST currently supports two applications: SERENDIP VI, a SETI spectrometer that is conducting a search for signs of technological life, and ALFABURST, a fast transient search system that is conducting a survey of fast radio bursts (FRBs). Based on the FRB event rate and the expected usage of ALFA, we expect 0–5 FRB detections over the coming year. SETIBURST also provides the option of plugging in more applications. We outline the motivation for our instrumentation scheme and the scientific motivation of the two surveys, along with their descriptions and related discussions.
Synergies between Asteroseismology and Three-dimensional Simulations of Stellar Turbulence
Authors: Arnett W. David , Moravveji E. 
Published: February 2017

Abstract
Turbulent mixing of chemical elements by convection has fundamental effects on the evolution of stars. The standard algorithm at present, mixing-length theory (MLT), is intrinsically local, and must be supplemented by extensions with adjustable parameters. As a step toward reducing this arbitrariness, we compare asteroseismically inferred internal structures of two Kepler slowly pulsating B stars (SPBs;

) to predictions of 321D turbulence theory, based upon well-resolved, truly turbulent three-dimensional simulations that include boundary physics absent from MLT. We find promising agreement between the steepness and shapes of the theoretically predicted composition profile outside the convective region in 3D simulations and in asteroseismically constrained composition profiles in the best 1D models of the two SPBs. The structure and motion of the boundary layer, and the generation of waves, are discussed.
Selection of Multi-Drug Resistant Influenza A and B Viruses under Zanamivir Pressure and their Replication Fitness in Ferrets
Authors: Oh Ding Yuan , Panozzo Jacqueline , Vitesnik Sophie , Farrukee Rubaiyea , Piedrafita David , Mosse Jennifer , Hurt Aeron C 
Published: February 2017

Background Intravenous zanamivir has been used to treat patients with severe influenza. Because the majority of cases (including immunocompromised patients) require the drug for an extended period of treatment, there is a higher risk that the virus will develop resistance. Therefore, knowing the possible amino acid substitutions that may arise in recently circulating influenza strains under prolonged zanamivir exposure and their impact on antiviral susceptibility is important. Methods Influenza A(H1N1)pdm09, A(H3N2) and B virus were serially passaged under increasing zanamivir pressure in vitro. Neuraminidase (NA) mutations that arose were introduced into recombinant viruses and the susceptibility to oseltamivir, zanamivir, peramivir and laninamivir was determined. The replication fitness of the recombinant variants was assessed in the ferret. Results NA mutations E119D (N1 numbering) and E117D (B numbering) were detected in A(H1N1)pdm09 and B (Victoria-lineage) viruses respectively and were associated with reduced susceptibility to all four NA inhibitors. No NA mutations were detected in the A(H3N2) or B (Yamagata-lineage) viruses. In ferrets, the A(H1N1) pdm09 E119D variant caused a lower degree of morbidity and the mutation was found to be unstable with E119 reverted virus detected 4 days post-infection of ferrets with the variant E119D virus. In contrast, the influenza B E117D variant was genetically stable in ferrets, caused a noticeable level of morbidity but had a significant reduction in replication fitness compared to wild-type virus. Conclusions The NA mutations E119D in influenza A(H1N1)pdm09 and E117D in influenza B viruses that arose under zanamivir pressure conferred resistance to multiple NA inhibitors but had compromised viral replication in ferrets compared to wild-type virus without antiviral drug pressure.
Impact of Tenofovir dose Adjustment on Both Estimated Glomerular Filtration Rate and Tenofovir trough Concentration
Authors: Bregigeon Sylvie , Solas Caroline , Faucher Olivia , Obry-Roguet Véronique , Tamalet Catherine , Poizot-Martin Isabelle 
Published: February 2017

Background Tenofovir disoproxil fumarate (TDF)-based regimen is a treatment option for HIV-infected patients. TDF dose adjustment is recommended in patients with impaired renal function. We assessed the impact of TDF dose adjustment on renal function and tenofovir trough concentration. Methods Fourteen HIV patients for whom TDF dose was adjusted (1 tablet/48 h) because of estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2, and/or due to a tenofovir trough concentration >90 ng/ml between 2006 and 2013 were selected. The eGFR was measured at baseline and 3, 6 and 12 months after TDF dose adjustment. Results A 50% TDF dose reduction resulted in a significant increase of the eGFR 3 months after dose adjustment (61.1 versus 72.8 ml/min/1.73 m2; P=0.003). Concomitantly, tenofovir trough concentration decreased from 175 to 66 ng/ml ( P=0.009). Antiviral efficacy was maintained in all patients. Conclusions TDF dose adjustment combined with therapeutic drug monitoring may be useful especially in patients at risk of kidney dysfunction.
Social labs in universities: Innovation and impact in medialab UGR
Authors: Romero-Frías Esteban , Robinson-García Nicolás 
Published: February 2017

Social laboratories, defined as experimental spaces for co-creation, have currently become the main centres of innovation. Medialabs are experimental laboratories of technologies and communication media which have co-evolved along with the digital society into becoming mediation laboratories of citizen experimentation, observing a confluence of both models. In the last years, these centres have expanded within the higher education context, generating new forms of innovation and posing the issue on how to measure the impact of such open spaces. This paper analyzes the origin and development of social laboratories in Spain. It first reviews their historical development since its antecedents in the 19th Century until the most recent initiatives. It focuses specifically on initiatives launched within the university context, highlighting their role as motors of innovation. Then, it presents the case of Medialab UGR, a co-creation and digital culture centre of social collaboration framed in the digital context. Finally, it offers a first approach towards the assessment of its social impact by using the Twitter and analyzes its capacity to mobilize and reach non-academic audiences. The findings show the plurality of actors involved in this type of networks as well as the difficulty and complexity of the task on the development of indicators that can comprise both, academic and social interests.Los laboratorios sociales, como espacios de experimentación y cocreación, se han convertido en una de las principales instituciones de innovación en nuestros días. En este marco, los medialabs surgen como un tipo de laboratorios centrados en la experimentación con tecnologías y medios de comunicación y evolucionan, con el desarrollo de la sociedad digital, hacia laboratorios de mediación ciudadana e innovación social. En los últimos tiempos se ha producido una expansión de estos modelos en el contexto universitario, generando casos de gran interés para el desarrollo de nuevas métricas del impacto académico en la sociedad. El presente trabajo aborda, en primer lugar, el concepto, origen y desarrollo de los laboratorios sociales en España y globalmente, centrándose específicamente en el espacio universitario y en los medialabs. En segundo lugar, expone la problemática de las métricas alternativas del impacto social, aportando una propuesta de análisis basada en Twitter como herramienta para identificar los distintos tipos de públicos que muestran interés y el nivel de participación que despierta su actividad. Por último, se aplica este análisis al caso de Medialab UGR en la Universidad de Granada, un laboratorio de cultura digital enfocado en la cocreación y colaboración social. Los resultados muestran la pluralidad de actores vinculados a este tipo de redes, así como la dificultad y complejidad de establecer indicadores que concilien tanto intereses académicos como sociales.
Online questionnaires use with automatic feedback for e-innovation in university students
Authors: Remesal Ana , Colomina Rosa-M. , Mauri Teresa , Rochera M.-José 
Published: February 2017

Technological tools have permeated higher education programs. However, their mere introduction does not guarantee instructional quality. This article presents the results of an innovation project aimed at fostering autonomous learning among students at a Pre-School and Primary Teacher Grade. For one semester all freshmen students used a system for autonomous learning embedded in the institutional online platform (Moodle), which included automatic formative feedback. The system was part of a complex formative assessment program. We present results of the experience concerning two aspects: the students’ actual use of the system, and their final appraisal of it. The quantitative descriptive analysis focuses on the students’ perspective to evaluate the adequacy of the instructional decisions. Results indicate that students need certain limits to be able to manage their learning better if we pursue the quality of innovation. These limits refer mainly to the time of accessibility and the limitation of attempts of practice. With respect to time, an appropriate span of time (neither too long nor too short) must be chosen; with respect to the number of attempts, it is expedient to limit rather than promote free endless access.
Las herramientas tecnológicas han impregnado plenamente la educación superior. No obstante, el mero añadido no garantiza per se su calidad. Este artículo expone los resultados de un proyecto de innovación para fomentar el aprendizaje autónomo en los Grados de Educación Infantil y Primaria. Durante un semestre todos los alumnos de primer curso pudieron usar un sistema de aprendizaje autónomo en la plataforma online institucional (Moodle), apoyado con feedback formativo automático. El sistema se insertaba en un programa complejo de evaluación formativa. Se presentan resultados atendiendo a dos aspectos: uso real de los estudiantes y valoración final del sistema por parte de estos. El análisis cuantitativo descriptivo se centra en la perspectiva del estudiante para evaluar la adecuación de las decisiones pedagógicas tomadas. Los resultados indican que los estudiantes necesitan ciertos límites para poder organizar mejor su propio aprendizaje si queremos potenciar la calidad de la innovación planteada. Estos límites se concretan en variables tales como el tiempo de disponibilidad y la limitación de intentos de práctica. En el primer caso se debe atender a la duración adecuada de la oferta del sistema: tanto el exceso como el defecto de tiempo afectan a la cantidad y uso que realizan los estudiantes. En el segundo caso, la restricción de intentos es preferible a la práctica libre.
Spanish journalists’ perception about their professional roles
Authors: Berganza Rosa , Lavín Eva , Piñeiro-Naval Valeriano 
Published: February 2017

The international empirical research about journalists’ perception of their professional roles and functions presents a remarkable increase in recent years, but not so in the Spanish case. In this research, which is part of the comparative transnational study “Worlds of Journalism Study”, we analyse data from a survey conducted in Spain (representative and stratified by type of media and Autonomous Community) to 390 journalists from 117 media, who were consulted about their work to detect their professional attitudes. The study identifies six roles: the watchdog, the speaker of citizenship, the instructor of the audience, favours the status quo, entertains public opinion and the disseminator of objective information. Professionals feel more identified with the role of speaker of citizenship, in relation with the Spanish political, economic and social changes in recent years. This function downplays the predominant role in the recent similar studies on Spanish journalists: the disseminator of objective information. We also found two large groups of journalists: the stimulators and the narcotizators of public opinion. Moreover, it was observed that some organizational factors (in particular, the property of media) and other individual ones (such as gender, age and years of work experience) significantly influence the perceptions of professional roles.
La investigación empírica internacional sobre la percepción que los periodistas tienen de sus roles y funciones profesionales presenta un notable auge en los últimos años, aunque no en el caso español. Esta investigación, que forma parte del estudio comparativo transnacional «Worlds of Journalism Study», analiza los datos de una encuesta realizada en España (representativa y estratificada por tipo de medio y por Comunidad Autónoma) a 390 periodistas de 117 medios de comunicación, quienes fueron consultados sobre su trabajo para detectar las funciones profesionales con las que más se identificaban. El estudio señala seis roles: el de perro guardián, el altavoz de la ciudadanía, el instructor de la audiencia, el favorecedor del statu quo, el que entretiene a la opinión pública y el difusor de información objetiva. En línea con la evolución política, económica y social de los últimos años en España, los profesionales se identifican más con el papel de altavoz de la ciudadanía. Esta función desplaza en importancia al rol protagonista de los estudios similares más recientes sobre periodistas españoles: el de difusor de la información objetiva. Se hallan también dos grandes grupos de periodistas: los estimuladores y los narcotizadores de la opinión pública. Además, se observa que algunos factores organizacionales (en concreto, la propiedad del medio) y otros individuales (el género, la edad y los años de experiencia laboral) influyen significativamente en las percepciones de los roles profesionales.
Omega Sign: A Distinct Optical Coherence Tomography Finding in Macular Combined Hamartoma of Retina and Retinal Pigment Epithelium
Authors: Kumar Vinod , Chawla Rohan , Tripathy Koushik 
Published: February 2017

BACKGROUND AND OBJECTIVE:
To report a distinct optical coherence tomography (OCT) appearance of macular combined hamartoma of retina and retinal pigment epithelium (CHRRPE).

PATIENTS AND METHODS:
This is a retrospective case series of four eyes of four patients with macular CHRRPE who were assessed with the help of color fundus photographs, swept-source OCT (SS-OCT), and fundus fluorescein angiography wherever required.

RESULTS:
All four patients presented with decreased visual acuity. SS-OCT in all patients showed adherent epiretinal membrane (ERM) and localized thickening of underlying retina. An omega-shaped disorganization of inner retinal layers was seen bounded posteriorly by the outer plexiform layer. This was termed, “Omega sign.”

CONCLUSION:
Omega sign is a characteristic feature of macular CHRRPE and may help to distinguish macular CHRRPEs from ERMs.

[
Ophthalmic Surg Lasers Imaging Retina.
2017;48:122–125.]
β2 Glycoprotein I Recognition Drives Th1 Inflammation in Atherosclerotic Plaques of Patients with Primary Antiphospholipid Syndrome
Authors: Benagiano Marisa , Gerosa Maria , Romagnoli Jacopo , Mahler Michael , Borghi Maria O. , Grassi Alessia , Della Bella Chiara , Emmi Giacomo , Amedei Amedeo , Silvestri Elena , Emmi Lorenzo , Prisco Domenico , Meroni Pier Luigi , D’Elios Mario M. 
Published: February 2017

Abstract
Antiphospholipid syndrome (APS) is characterized by recurrent arterial/venous thrombosis and miscarriages in the persistent presence of autoantibodies against phospholipid-binding proteins (aPLs), such as β2 glycoprotein I (β2GPI). In addition to the aPL thrombophilic effect, arterial thrombosis was related to accelerated atherosclerosis in animal models; however, contrasting findings were reported in primary APS patients with regard to the increased number of plaques or abnormal arterial wall thickness. We investigated the cytokine production induced by β2GPI in activated T cells that infiltrate in vivo atherosclerotic lesions of primary APS patients with atherothrombosis. We also examined the helper function of β2GPI-specific T cells for monocyte matrix metalloproteinase-9 and tissue factor production, as well as their cytolytic potential and their helper function for Ab production. APS patients with atherothrombosis harbor in vivo–activated CD4+ T cells that recognize β2GPI in atherothrombotic lesions. β2GPI induces T cell proliferation and IFN-γ expression in plaque-derived T cell clones. β2GPI-specific T cells display helper function for monocyte matrix metalloproteinase-9 and tissue factor production and promote Ig production in autologous B cells. Moreover, plaque-derived β2GPI-specific CD4+ T lymphocytes express perforin-mediated and Fas/Fas ligand–mediated cytotoxicity. β2GPI, and especially the DI domain, drive a local Th1 inflammatory response, with subsequent plaque instability that eventually favors atherothrombosis. This finding may explain the association between aPLs and arterial thrombosis, despite the lack of evidence of surrogate markers for atherosclerosis in primary APS.
Long-lived contrails and convective cirrus above the tropical tropopause
Authors: Schumann Ulrich , Kiemle Christoph , Schlager Hans , Weigel Ralf , Borrmann Stephan , D'Amato Francesco , Krämer Martina , Matthey Renaud , Protat Alain , Voigt Christiane , Volk C. Michael 
Published: February 2017

Abstract. This study has two objectives: (1) it characterizes contrails at very low temperatures and (2) it discusses convective cirrus in which the contrails occurred. (1) Long-lived contrails and cirrus from overshooting convection are investigated above the tropical tropopause at low temperatures down to −88 °C from measurements with the Russian high-altitude research aircraft M-55 Geophysica, as well as related observations during the SCOUT-O3 field experiment near Darwin, Australia, in 2005. A contrail was observed to persist below ice saturation at low temperatures and low turbulence in the stratosphere for nearly 1 h. The contrail occurred downwind of the decaying convective system Hector of 16 November 2005. The upper part of the contrail formed at 19 km altitude in the tropical lower stratosphere at ∼ 60 % relative humidity over ice at −82 °C. The ∼ 1 h lifetime is explained by engine water emissions, slightly enhanced humidity from Hector, low temperature, low turbulence, and possibly nitric acid hydrate formation. The long persistence suggests large contrail coverage in case of a potential future increase of air traffic in the lower stratosphere. (2) Cirrus observed above the strongly convective Hector cloud on 30 November 2005 was previously interpreted as cirrus from overshooting convection. Here we show that parts of the cirrus were caused by contrails or are mixtures of convective and contrail cirrus. The in situ data together with data from an upward-looking lidar on the German research aircraft Falcon, the CPOL radar near Darwin, and NOAA-AVHRR satellites provide a sufficiently complete picture to distinguish between contrail and convective cirrus parts. Plume positions are estimated based on measured or analyzed wind and parameterized wake vortex descent. Most of the non-volatile aerosol measured over Hector is traceable to aircraft emissions. Exhaust emission indices are derived from a self-match experiment of the Geophysica in the polar stratosphere in 2010. The number of ice particles in the contrails is less than 1 % of the number of non-volatile aerosol particles, possibly because of sublimation losses and undetected very small ice particles. The radar data show that the ice water content in convective overshoots is far higher than measured along the flight path. These findings add insight into overshooting convection and are of relevance with respect to hydration of the lower stratosphere.