bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering the Charge Transfer in all 2D Graphene-Nanoplatelets Heterostructure Photodetectors
Authors: Robin A. , Lhuillier E. , Xu X. Z. , Ithurria S. , Aubin H. , Ouerghi A. , Dubertret B. 
Published: May 2016

AbstractTwo dimensional layered (i.e. van der Waals) heterostructures open up great prospects, especially in photodetector applications. In this context, the control of the charge transfer between the constituting layers is of crucial importance. Compared to bulk or 0D system, 2D materials are characterized by a large exciton binding energy (0.1–1 eV) which considerably affects the magnitude of the charge transfer. Here we investigate a model system made from colloidal 2D CdSe nanoplatelets and epitaxial graphene in a phototransistor configuration. We demonstrate that using a heterostructured layered material, we can tune the magnitude and the direction (i.e. electron or hole) of the charge transfer. We further evidence that graphene functionalization by nanocrystals only leads to a limited change in the magnitude of the 1/f noise. These results draw some new directions to design van der Waals heterostructures with enhanced optoelectronic properties.
Oxytocin Protects against Stress-Induced Cell Death in Murine Pancreatic β-Cells
Authors: Watanabe Sayaka , Wei Fan-Yan , Matsunaga Tomomi , Matsunaga Nanami , Kaitsuka Taku , Tomizawa Kazuhito 
Published: May 2016

AbstractOxytocin (Oxt) is a key neuropeptide that regulates maternal behaviors as well as social behaviors in mammals. Interestingly, recent studies have shown that the impairment of Oxt signaling is associated with the disturbance of metabolic homeostasis, resulting in obesity and diabetes. However, the molecular mechanism by which Oxt signaling controls metabolic responses is largely unknown. Here, we report that Oxt signaling attenuates the death of pancreatic beta cells in islets exposed to cytotoxic stresses. The protective effect of Oxt was diminished in islets isolated from oxytocin receptor knockout (Oxtr−/−) mice. Oxtr−/− mice developed normally, but exhibited impaired insulin secretion and showed glucose intolerance under a high-fat diet. Mechanistically, the deficiency of Oxtr impaired MAPK/ERK-CREB signaling, which exaggerated the endoplasmic reticulum stress response and ultimately increased the death of beta cells in pancreatic islets under stressed conditions. These results reveal that Oxt protects pancreatic beta cells against death caused by metabolic stress and Oxt signaling may be a potential therapeutic target.
Enhanced DSSCs efficiency via Cooperate co-absorbance (CdS QDs) and plasmonic core-shell nanoparticle (Ag@PVP)
Authors: Amiri Omid , Salavati-Niasari Masoud , Bagheri Samira , Yousefi Amin Termeh 
Published: May 2016

AbstractThis paper describes cooperate the co-absorbance (CdS QDs) and the plasmonic core-shell nanoparticles (Ag@PVP) of dye synthesized solar cells in which CdS QDs and Ag@PVP are incorporated into the TiO2 layer. Cooperative nanoparticles show superior behavior on enhancing light absorption in comparison with reference cells. Cooperated DSSC exhibits the best performance with the power conversion efficiency of 7.64% which is superior to that of the free–modified DSSC with the PCE of 5%. Detailed studies offer an effective approach to enhance the efficiency of dye synthesized solar cells.
Absence of NMDA receptor antibodies in the rare association between Type 1 Narcolepsy and Psychosis
Authors: Dauvilliers Y. , Gaig C. , Barateau L. , Graus F. , Iranzo A. , Lopez R. , Santamaria J. 
Published: May 2016

AbstractFrequency and mechanisms underlying the association between narcolepsy type 1 (NT1) and psychosis remain unclear with potential role for a common immune pathway. We estimated the frequency of psychosis and its characteristics in NT1 at two European sleep centers (France, n = 381; Spain, n = 161) and measured IgG autoantibodies that recognize the GluN1 subunit of the NMDAR in 9 patients with NT1 with psychosis and 25 NT1 patients without psychosis. Ten NT1 patients (6 in France, 4 in Spain) were diagnosed with comorbid psychosis, a frequency of 1.8%. One patient reported psychotic symptoms few months before narcolepsy onset, two patients few months after onset and one patient one year after onset but after modafinil introduction. The six remaining patients reported long delays between NT1 and psychosis onset. Half the patients, mostly male adults, reported onset or worsening of psychotic symptoms after medication. We found no IgG antibodies to NR1/NR2B heteromers of the NMDARs in patients with NT1 with or without psychosis. To conclude, psychosis is rare in NT1, with limited evidence for a key impact of stimulants and no association with anti-NMDAR antibodies. However, dramatic NT1 and schizophrenia exists especially in early onset NT1, which may lead to inappropriate diagnosis and management.
Novel chemical synthesis and characterization of copper pyrovanadate nanoparticles and its influence on the flame retardancy of polymeric nanocomposites
Authors: Ghiyasiyan-Arani Maryam , Masjedi-Arani Maryam , Ghanbari Davood , Bagheri Samira , Salavati-Niasari Masoud 
Published: May 2016

AbstractIn this work, copper pyrovanadate (Cu3V2O7(OH)2(H2O)2) nanoparticles have been synthesized by a simple and rapid chemical precipitation method. Different copper-organic complexes were used to control the size and morphology of products. The morphology and structure of the as-synthesized products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectrum, electron dispersive X-ray spectroscopy (EDX), thermal gravimetric analysis (TGA), differential thermal analysis (DTA) and photoluminescence (PL) spectroscopy. The influence of copper pyrovanadate nanostructures on the flame retardancy of the polystyrene, poly vinyl alcohol and cellulose acetate was studied. Dispersed nanoparticles play the role of a magnetic barrier layer, which slows down product volatilization and prevents the flame and oxygen from the sample during decomposition of the polymer. Cu3V2O7(OH)2(H2O)2 is converted to Cu3V2O8 with an endothermic reaction which simultaneously releases water and decrease the temperature of the flame region.
Using Drosophila as an integrated model to study mild repetitive traumatic brain injury
Authors: Barekat Ayeh , Gonzalez Arysa , Mauntz Ruth E. , Kotzebue Roxanne W. , Molina Brandon , El-Mecharrafie Nadja , Conner Catherine J. , Garza Shannon , Melkani Girish C. , Joiner William J. , Lipinski Marta M. , Finley Kim D. , Ratliff Eric P. 
Published: May 2016

AbstractTraumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. In addition, there has been a growing appreciation that even repetitive, milder forms of TBI (mTBI) can have long-term deleterious consequences to neural tissues. Hampering our understanding of genetic and environmental factors that influence the cellular and molecular responses to injury has been the limited availability of effective genetic model systems that could be used to identify the key genes and pathways that modulate both the acute and long-term responses to TBI. Here we report the development of a severe and mild-repetitive TBI model using Drosophila. Using this system, key features that are typically found in mammalian TBI models were also identified in flies, including the activation of inflammatory and autophagy responses, increased Tau phosphorylation and neuronal defects that impair sleep-related behaviors. This novel injury paradigm demonstrates the utility of Drosophila as an effective tool to validate genetic and environmental factors that influence the whole animal response to trauma and to identify prospective therapies needed for the treatment of TBI.
Thickness-dependent transport channels in topological insulator Bi2Se3 thin films grown by magnetron sputtering
Authors: Wang Wen Jie , Gao Kuang Hong , Li Zhi Qing 
Published: May 2016

AbstractWe study the low-temperature transport properties of Bi2Se3 thin films grown by magnetron sputtering. A positive magnetoresistance resulting from the weak antilocalization (WAL) effect is observed at low temperatures. The observed WAL effect is two dimensional in nature. Applying the Hikami-Larkin-Nagaoka theory, we have obtained the dephasing length. It is found that the temperature dependence of the dephasing length cannot be described only by the Nyquist electron-electron dephasing, in conflict with prevailing experimental results. From the WAL effect, we extract the number of the transport channels, which is found to increase with increasing the thickness of the films, reflecting the thickness-dependent coupling between the top and bottom surface states in topological insulator. On the other hand, the electron-electron interaction (EEI) effect is observed in temperature-dependent conductivity. From the EEI effect, we also extract the number of the transport channel, which shows similar thickness dependence with that obtained from the analysis of the WAL effect. The EEI effect, therefore, can be used to analyze the coupling effect between the top and bottom surface states in topological insulator like the WAL effect.
Extraordinary wavelength reduction in terahertz graphene-cladded photonic crystal slabs
Authors: Williamson Ian A. D. , Mousavi S. Hossein , Wang Zheng 
Published: May 2016

AbstractPhotonic crystal slabs have been widely used in nanophotonics for light confinement, dispersion engineering, nonlinearity enhancement and other unusual effects arising from their structural periodicity. Sub-micron device sizes and mode volumes are routine for silicon-based photonic crystal slabs, however spectrally they are limited to operate in the near infrared. Here, we show that two single-layer graphene sheets allow silicon photonic crystal slabs with submicron periodicity to operate in the terahertz regime, with an extreme 100× wavelength reduction from graphene’s large kinetic inductance. The atomically thin graphene further leads to excellent out-of-plane confinement and consequently photonic-crystal-slab band structures that closely resemble those of ideal two-dimensional photonic crystals, with broad band gaps even when the slab thickness approaches zero. The overall photonic band structure not only scales with the graphene Fermi level, but more importantly scales to lower frequencies with reduced slab thickness. Just like ideal 2D photonic crystals, graphene-cladded photonic crystal slabs confine light along line defects, forming waveguides with the propagation lengths on the order of tens of lattice constants. The proposed structure opens up the possibility to dramatically reduce the size of terahertz photonic systems by orders of magnitude.
MiR-125b regulates endometrial receptivity by targeting MMP26 in women undergoing IVF-ET with elevated progesterone on HCG priming day
Authors: Chen Cheng , Zhao Yue , Yu Yang , Li Rong , Qiao Jie 
Published: May 2016

AbstractOn the women undergoing IVF-ET with elevated progesterone on human chorionic gonadotrophin priming, the assisted reproductive technology outcome is poor. But, due to the unknown mechanism of this process, no effective method has been found to overcome this difficulty. Here, we investigated the roles of miR-125b and its target gene, MMP26, in endometrial receptivity (ER) in these women. The expression of miR-125b was significantly up-regulated in EECs in women with elevated progesterone during the window of implantation and it showed a progesterone-dependent effect in vitro. Similarly, the expression of miR-125b was significantly up-regulated in the preimplantation period and was down-regulated in the implantation period and the post-implantation period in mouse EECs. In addition, miR-125b showed a greater decrease at implantation sites than it did at interimplantation sites. The luciferase report assay demonstrated that MMP26 is a target gene of miR-125b. And the expression profile of MMP26 showed an inverse relationship with miR-125b in vivo and in vitro. Overexpression of miR-125b in human EECs inhibited cell migration and invasion. Gain-of-function of miR-125b induced a significant decrease in the number of implantation sites. In conclusion, these data shed new light on how miR-125b triggers ER decline through the regulation of MMP26 function.
Highly Sensitive and Selective In-Situ SERS Detection of Pb2+, Hg2+, and Cd2+ Using Nanoporous Membrane Functionalized with CNTs
Authors: Shaban Mohamed , Galaly A. R. 
Published: May 2016

AbstractPorous Anodic Alumina (PAA) membrane was functionalized with CoFe2O4 nanoparticles and used as a substrate for the growing of very long helical-structured Carbon Nanotubes (CNTs) with a diameter less than 20 nm. The structures and morphologies of the fabricated nanostructures were characterized by field emission- scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDX), and Raman spectroscopy. By uploading the CNTs on PAA, the characteristic Raman peaks of CNTs and PAA showed 4 and 3 times enhancement, respectively, which leads to more sensitive Surface-Enhanced Raman Spectroscopy (SERS) substrates. For comparison, PAA and CNTs/PAA arrays were used as SERS substrates for the detection of Hg2+, Cd2+, and Pb2+. The proposed sensor demonstrated high sensitivity and selectivity between these heavy metal ions. CNTs/PAA sensor showed excellent selectivity toward Pb2+ over other metal ions, where the enhancement factor is decreased from ~17 for Pb2+ to ~12 for Hg2+ and to ~4 for Cd2+. Therefore, the proposed CNTs/PAA sensor can be used as a powerful tool for the determination of heavy metal ions in aqueous solutions.
Isolation and co-culture of rat parenchymal and non-parenchymal liver cells to evaluate cellular interactions and response
Authors: Bale Shyam Sundhar , Geerts Sharon , Jindal Rohit , Yarmush Martin L. 
Published: May 2016

AbstractThe liver is a central organ in the human body and first line of defense between host and external environment. Liver response to any external perturbation is a collective reaction of resident liver cells. Most of the current in vitro liver models focus on hepatocytes, the primary metabolic component, omitting interactions and cues from surrounding environment and non-parenchymal cells (NPCs). Recent studies suggest that contributions of NPCs are vital, particularly in disease conditions and outcomes of drugs and their metabolites. Along with hepatocytes, NPCs–Kupffer (KC), sinusoidal endothelial (LSEC) and stellate cells (SC) are major cellular components of the liver. Incorporation of primary cells in in vitro liver platforms is essential to emulate the functions of the liver and its overall response. Herein, we isolate individual NPC cell fractions from rat livers and co-culture them in a transwell format incorporating primary rat hepatocytes with LSECs, SCs and KCs. Our results indicate that the presence and contributions of multiple cells within the co-culture capture the interactions between hepatocytes and NPC and modulates the responses to inflammatory stimulus such as LPS. The isolation and co-culture methods could provide a stable platform for creating in vitro liver models that provide defined functionality beyond hepatocytes alone.
High water content in primitive continental flood basalts
Authors: Xia Qun-Ke , Bi Yao , Li Pei , Tian Wei , Wei Xun , Chen Han-Lin 
Published: May 2016

AbstractAs the main constituent of large igneous provinces, the generation of continental flood basalts (CFB) that are characterized by huge eruption volume (>105 km3) within short time span (<1–3 Ma) is in principle caused by an abnormally high temperature, extended decompression, a certain amount of mafic source rocks (e.g., pyroxenite), or an elevated H2O content in the mantle source. These four factors are not mutually exclusive. There are growing evidences for high temperature, decompression and mafic source rocks, albeit with hot debate. However, there is currently no convincing evidence of high water content in the source of CFB. We retrieved the initial H2O content of the primitive CFB in the early Permian Tarim large igneous province (NW China), using the H2O content of ten early-formed clinopyroxene (cpx) crystals that recorded the composition of the primitive Tarim basaltic melts and the partition coefficient of H2O between cpx and basaltic melt. The arc-like H2O content (4.82 ± 1.00 wt.%) provides the first clear evidence that H2O plays an important role in the generation of CFB.
Use of Crowdsourcing to Assess the Ecological Validity of Perceptual-Training Paradigms in Dysarthria
Authors: Lansford Kaitlin L. , Borrie Stephanie A. , Bystricky Lukas 
Published: May 2016

PurposeIt has been documented in laboratory settings that familiarizing listeners with dysarthric speech improves intelligibility of that speech. If these findings can be replicated in real-world settings, the ability to improve communicative function by focusing on communication partners has major implications for extending clinical practice in dysarthria rehabilitation. An important step toward development of a listener-targeted treatment approach requires establishment of its ecological validity. To this end, the present study leveraged the mechanism of crowdsourcing to determine whether perceptual-training benefits achieved by listeners in the laboratory could be elicited in an at-home computer-based scenario.MethodPerceptual-training data (i.e., intelligibility scores from a posttraining transcription task) were collected from listeners in 2 settings—the laboratory and the crowdsourcing website Amazon Mechanical Turk.ResultsConsistent with previous findings, results revealed a main effect of training condition (training vs. control) on intelligibility scores. There was, however, no effect of training setting (Mechanical Turk vs. laboratory). Thus, the perceptual benefit achieved via Mechanical Turk was comparable to that achieved in the laboratory.ConclusionThis study provides evidence regarding the ecological validity of perceptual-training paradigms designed to improve intelligibility of dysarthric speech, thereby supporting their continued advancement as a listener-targeted treatment option.
Knowing What We're Doing: Why Specification of Treatment Methods Is Critical for Evidence-Based Practice in Speech-Language Pathology
Authors: Turkstra Lyn S. , Norman Rocío , Whyte John , Dijkers Marcel P. , Hart Tessa 
Published: May 2016

Purpose
The purpose of this clinical focus article is to describe the conceptual framework of the multidisciplinary rehabilitation treatment taxonomy (RTT) and illustrate its potential use in speech-language pathology (SLP) clinical practice and research.

Method
The method used was a critical discussion.

Results

Current methods of defining and classifying SLP and other rehabilitation interventions maintain the “black box” of rehabilitation by referring to hours or days of therapy or using problem-oriented labels (e.g.,
naming treatment
) to describe treatments, none of which reveal what is actually done to effect desired changes in patient functioning. The RTT framework uses treatment targets, ingredients, and mechanisms of action defined by treatment theory to specify SLP and other rehabilitation interventions with greater precision than current methods of treatment labeling and classification. It also makes a distinction between the target of treatment at which ingredients are directed and broader aims of treatment, which may be downstream effects explained instead by enablement/disablement theory.

Conclusion
Future application of the RTT conceptual scheme to SLP intervention may enhance clinical practice, research, and knowledge translation as well as training and program evaluation efforts.
Highly selective wideband bandpass filter using combined microstrip/coplanar waveguide structure
Authors: Gholipour V. , Moshiri S.M.M. , Alighanbari A. , Yahaghi A. 
Published: May 2016

A highly selective wideband bandpass filter using a combined coplanar waveguide (CPW) and microstrip structure is proposed. The CPW section is responsible for creating a 4–8 GHz bandwidth. The microstrip split ring resonators and shorted coupled lines are used to sharpen the transitions between the passband and the stopband at lower and upper edges. The CPW section is fed by a microstrip host line and consists of two symmetrical coupled stepped‐impedance resonators to limit the bandwidth of the desired filter. A lumped element circuit model is presented and comparisons with experimental and simulation results confirm great compatibility and performance. The measurement results confirm a return loss larger than 15.3 dB in the passband, an out‐of‐band rejection greater than 15 dB.
Nuclear receptor REV-ERBα mediates circadian sensitivity to mortality in murine vesicular stomatitis virus-induced encephalitis
Authors: Gagnidze Khatuna , Hajdarovic Kaitlyn H. , Moskalenko Marina , Karatsoreos Ilia N. , McEwen Bruce S. , Bulloch Karen 
Published: May 2016

SignificanceImmune parameters exhibit circadian periodicity. We show that disease progression and survival following intranasal infection with a neurotropic virus depends on the circadian time of infection. Infection occurring at the start of the rest period leads to higher mortality than infection at the start of the active period and is associated with increased numbers of inflammatory cells and higher levels of chemokine (C-C motif) ligand 2 (CCL2). The highest expression of REV-ERBα, a component of the molecular circadian clock, coincides with the start of the active cycle, when vesicular stomatitis virus infection leads to lower mortality. Inhibiting REV-ERBα–mediated suppression of CCL2 at the start of the active cycle abolishes protection in these animals, thus providing insight into circadian regulation of immune response.
OrfM: a fast open reading frame predictor for metagenomic data
Authors: Woodcroft Ben J. , Boyd Joel A. , Tyson Gene W. 
Published: May 2016

Abstract
Summary: Finding and translating stretches of DNA lacking stop codons is a task common in the analysis of sequence data. However, the computational tools for finding open reading frames are sufficiently slow that they are becoming a bottleneck as the volume of sequence data grows. This computational bottleneck is especially problematic in metagenomics when searching unassembled reads, or screening assembled contigs for genes of interest. Here, we present OrfM, a tool to rapidly identify open reading frames (ORFs) in sequence data by applying the Aho–Corasick algorithm to find regions uninterrupted by stop codons. Benchmarking revealed that OrfM finds identical ORFs to similar tools (‘GetOrf’ and ‘Translate’) but is four-five times faster. While OrfM is sequencing platform-agnostic, it is best suited to large, high quality datasets such as those produced by Illumina sequencers.
Availability and Implementation: Source code and binaries are freely available for download at http://github.com/wwood/OrfM or through GNU Guix under the LGPL 3+ license. OrfM is implemented in C and supported on GNU/Linux and OSX.
Contacts: b.woodcroft@uq.edu.au
Supplementary information : Supplementary data are available at Bioinformatics online.