bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression following traumatic brain injury in mice is associated with down-regulation of hippocampal astrocyte glutamate transporters by thrombin
Authors: Piao Chun-Shu , Holloway Ashley L , Hong-Routson Sue , Wainwright Mark S 
Published: November 2017

Depression after traumatic brain injury (TBI) is common but the mechanisms by which TBI causes depression are unknown. TBI decreases glutamate transporters GLT-1 and GLAST and allows extravasation of thrombin. We examined the effects of thrombin on transporter expression in primary hippocampal astrocytes. Application of a PAR-1 agonist caused down-regulation of GLT-1, which was prevented by inhibition of Rho kinase (ROCK). To confirm these mechanisms in vivo, we subjected mice to closed-skull TBI. Thrombin activity in the hippocampus increased one day following TBI. Seven days following TBI, expression of GLT-1 and GLAST was reduced in the hippocampus, and this was prevented by administration of the PAR-1 antagonist SCH79797. Inhibition of ROCK attenuated the decrease in GLT-1, but not GLAST, after TBI. We measured changes in glutamate levels in the hippocampus seven days after TBI using an implanted biosensor. Stress-induced glutamate levels were significantly increased following TBI and this was attenuated by treatment with the ROCK inhibitor fasudil. We quantified depressive behavior following TBI and found that inhibition of PAR-1 or ROCK decreased these behaviors. These results identify a novel mechanism by which TBI results in down-regulation of astrocyte glutamate transporters and implicate astrocyte and glutamate transporter dysfunction in depression following TBI.
Return to Play After Hip Arthroscopic Surgery for Femoroacetabular Impingement in Professional Soccer Players
Authors: Locks Renato , Utsunomiya Hajime , Briggs Karen K. , McNamara Shannen , Chahla Jorge , Philippon Marc J. 
Published: November 2017

Background: Arthroscopic hip surgery has been shown to be effective in returning professional athletes back to play at a high level of performance in different sports. Limited information exists regarding professional soccer players and their return to play. Purpose: To determine the rate and time to return to sport for professional soccer players after hip arthroscopic surgery for the treatment of femoroacetabular impingement (FAI) and to identify possible risk factors associated with a delay in returning to play. Study Design: Case series; Level of evidence, 4. Methods: Professional soccer players who underwent hip arthroscopic surgery for FAI by a single surgeon between 2005 and 2015 were evaluated. Data retrieved from www.mlssoccer.com , www.fifa.com , www.transfermarkt.co.uk , and www.wikipedia.org included information on each player’s professional career, participation on the national team, length of professional career before surgery, number of appearances (games) before surgery, time between surgery and first appearance in a professional game, and number of appearances after surgery. Other data were obtained from the patient’s medical records. Results: Twenty-four professional soccer players (26 hips) were included. The mean age at surgery was 25.0 ± 4.0 years (range, 19-32 years). A total of 96% of patients were able to return to play at the professional level. The mean time between surgery and the first professional game played was 9.2 months (range, 1.9-24.0 months). On average, players played in 70 games after surgery (range, 0-224). National team players were able to return to play significantly earlier than the rest of the players (median, 5.7 months vs 11.6 months, respectively; P = .018). Severe chondral damage and microfracture did not interfere with return to play. Conclusion: The arthroscopic management of FAI in symptomatic professional soccer players allowed 96% of them to return to play. Players with national team experience were able to return to play earlier than those without it. Severe chondral damage and microfracture did not interfere with return to play.
Effects of the New York State Concussion Management and Awareness Act (“Lystedt Law”) on Concussion-Related Emergency Health Care Utilization Among Adolescents, 2005-2015
Authors: Baker David R. , Kulick Erin R. , Boehme Amelia K. , Noble James M. 
Published: November 2017

Background: All states have enacted legislation addressing the management of sports-related concussions (SRCs) in adolescent athletes. The effect of these laws on health care utilization is uncertain. Hypothesis/Purpose: The purpose was to evaluate the effects of New York’s 2011 Concussion Management and Awareness Act (“Lystedt Law”) on emergency department (ED) concussion health care visits (EDCHVs) and brain imaging utilization. It was hypothesized that New York concussion legislation would have a significant temporal effect on EDCHVs. Study Design: Descriptive epidemiology study. Methods: Using the New York State Department of Health Statewide Planning and Research Cooperative System (SPARCS) database, trends in EDCHVs from 2005 to 2015 were identified among 12- to 18-year-old patients, comprising 5,740,403 total ED visits. Results: Overall, 208,024 EDCHVs, including 54,669 for an SRC, occurred during the study period. EDCHVs increased from 13,664 (2.74% of all ED visits) in 2005 to a peak of 21,374 (4.26%) in 2013, with greatest relative increases from 2008 to 2013. SRCs followed a similar trend: 3213 (0.64%) in 2005 to a peak of 6197 (1.24%) in 2013. Brain imaging utilization decreased by 5.3% for EDCHVs and 15.4% for SRCs (all comparisons year-by-year and for trends; P < .001). Conclusion: The period of greatest increases in EDCHVs and decreases in brain imaging utilization for SRCs preceded New York concussion legislation by several years, suggesting a minimal direct effect on emergency care–seeking behavior for concussions. Instead, increased public awareness of SRCs and imaging guidelines may have driven EDCHV trends and imaging practices.
Risk factors for non-fatal occupational injuries among construction workers: A case–control study
Authors: Khashaba E , El-Helaly M , El-Gilany AH , Motawei SM , Foda S 
Published: November 2017

Background: Substance abuse is a serious problem, because it affects both workers and young people. Prevalence and consequences of cannabis abuse among construction workers in particular are not well studied in Egypt. Objectives: To determine the association between non-fatal occupational injuries among construction workers and their demographic and occupational factors and to assess the frequency of cannabis abuse and its relationship to injury severity and workdays lost. Subjects and methods: A case–control study was conducted at Mansoura Emergency Hospital. Cases were 100 acutely injured male workers. A control group of 90 healthy age-matched workers was selected from 8 construction sites. Workers were interviewed, and a questionnaire was completed that included socio-demographic data, full occupational history, and causes and type of injury. Injury outcome measures included lost workdays and the injury severity score (ISS). Cannabis abuse in injured workers was monitored by preliminary testing of urine and confirmatory testing of blood. Results: Logistic regression analysis revealed that the independent predictors of occupational injuries were rural residence, being a carpenter or painter and past history of injuries. The most common accidents were slipping falls (62%). Confirmed cannabis test was positive in 51.1% of the injured workers. Median days away from work were greater among cannabis users than non-users. The ISS was significantly higher among users compared to non-users ( p < 0.05). Conclusion: Cannabis abuse can increase injury severity and prolong workdays lost. Drug testing is recommended for at-risk construction workers with inadequate safety measures.
Nanomicelle drug with acid-triggered doxorubicin release and enhanced cellular uptake ability based on mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid copolymers
Authors: Cao Li , Xiao Yi , Lu Wei , Liu Shiyuan , Gan Lin , Yu Jiahui , Huang Jin 
Published: November 2017

In order to achieve the passive tumor targeting and acid-triggered drugs release in lysosomes, optimized delivery system for doxorubicin based on pH-sensitive complex nanomicelles with suitable particle size was developed in this research. Particularly, poly(L-succinimide) was thoroughly ring-opened by ethylenediamine to give the poly(N-(2-aminoethyl)-L-aspartamide). Then, graft copolymer mPEG-graft-poly(N-(2-aminoethyl)-L-aspartamide)-hexahydrophthalic acid (mPEG-g-P(ae-Asp)-Hap) was synthesized by grafting mPEG-2000 and hexahydrophthalic anhydride onto poly(N-(2-aminoethyl)-L-aspartamide). In vitro studies revealed that mPEG-g-P(ae-Asp)-Hap copolymer was stable in neutral solutions but tend to be hydrolyzed under acidic condition, which was attributed to the acid-sensitive properties of hexahydrophthalic amides (β-carboxylic amides). MPEG-g-P(ae-Asp)-Hap copolymer with critical aggregation concentration of 0.166 mg·mL−1 could self-assemble into stable blank nanomicelles with an average particle hydrodynamic diameter of 98.1 nm, but the hydrodynamic diameter of doxorubicin-loaded nanomicelles (mPEG-g-P(ae-Asp)-Hap·Dox) was smaller and approximately 77.5 nm. MPEG-g-P(ae-Asp)-Hap·Dox nanomicelles showed sustained drug release profiles over 34 h, and the cumulative drug release showed a tendency to increase from 25% to 62% with the pH value decreasing from 7.4 to 5.0 due to the acid-triggered disassembly of nanomicelles. The cytotoxicity of mPEG-g-P(ae-Asp)-Hap·Dox nanomicelles against A549 treated with 40 mM NH4Cl (lysosomotropic weak bases) was decreased significantly than that without NH4Cl treatment, further confirmed the drug release from the nanomicelles was triggered by the low pH value of lysosome (pH 5.0). Compared with doxorubicin HCl, mPEG-g-P(ae-Asp)-Hap·Dox nanomicelle drug showed enhanced cellular uptake ability during 2 or 4 h of incubation due to the endocytosis mechanism of nanomicelle drug. In summary, the cleavage of pH-sensitive β-carboxylic amides bonds on the hydrophobic branch of mPEG-g-P(ae-Asp)-Hap copolymer triggered the disassembly of the nanomicelles and release of doxorubicin in the acidic lysosomal compartments of cancer cells. These nanomicelles exhibited excellent potential for drug delivery due to their smart properties-PEGylation, suitable size, and acid-triggered drug release.
Determination of critical operating and geometrical parameters in diesel injectors through one dimensional modelling, design of experiments and an analysis of variance
Authors: Salvador Francisco J , Carreres Marcos , Crialesi-Esposito Marco , Plazas Alejandro H 
Published: November 2017

In this paper, a design of experiments and a statistical analysis of variance (ANOVA) are performed to determine the parameters that have more influence on the mass flow rate profile in diesel injectors. The study has been carried out using a one dimensional model previously implemented by the authors. The investigation is split into two different parts. First, the analysis is focused on functional parameters such as the injection and discharge pressures, the energizing time and the fuel temperature. In the second part, the influence of 37 geometrical parameters, such as the diameters of hydraulic lines, calibrated orifices and internal volumes, among others, are analysed. The objective of the study is to quantify the impact of small variations in the nominal value of these parameters on the injection rate profile for a given injector operating condition. In the case of the functional parameters, these small variations may be attributed to possible undesired fluctuations in the conditions that the injector is submitted to. As far as the geometrical and flow parameters are concerned, the small variations studied are representative of manufacturing tolerances that could influence the injected mass flow rate. As a result, it has been noticed that the configuration of the inlet and outlet orifices of the control volume, together with the discharge coefficient of the inlet orifice, among a few others, play a remarkable role in the injector performance. The reason resides in the fact that they are in charge of controlling the behaviour of the pressure in the control volume, which importantly influences injector dynamics and therefore the injection process. Variations of only 5% in the diameter of these orifices strongly modify the shape of the rate of injection curve, influencing both the injection delay and the duration of the injection process, consequently changing the total mass delivered.
Where River Meets the Sea
Authors: Buisson Marie-Charlotte , Das Arijit , Mukherji Aditi 
Published: November 2017

Regular supply of maintenance fund for water infrastructures in costal Bangladesh is a necessary condition for the existence of river embankments. This article reviews a number of efforts to identify rules and conditions helping the regular supply of maintenance fund. A number of studies have used experimental games to replicate a real-life situation. The experimental results show that participants from Local Government Engineering Department polders significantly contribute more than players from Bangladesh Water Development Board polders which indicate importance of institutional environment. Also, our study finds significant importance of economic homogeneity in the group as well as proportional sharing of benefits increases the level of contribution. JEL: C93, Z13, D74
A Comparison of the Long-term Health Related Quality of Life and Handicap of Stroke Patients in Mainland China and Hong Kong
Authors: Kwok T , Jin X , Yeung F , Cheng J , Lo RSK , Lam CLK , Yuan HJ , Woo J 
Published: November 2017

Purpose To compare health related quality of life (HRQOL) and handicap of stroke survivors in Hong Kong (HK) and Chengdu (CD) in Mainland China. Method Fifty-four pairs of first ever stroke patients in CD and in HK matched by age, sex and Modified Barthel Index (MBI) were interviewed using a structured questionnaire at 16–36 months after stroke. HRQOL and handicap outcomes were evaluated by the Chinese version of the Short-Form Health Survey (SF-36) and London Handicap Scale (LHS) respectively. Results Compared to stroke patients in CD, HK subjects reported significantly greater handicap, especially in the occupation domain. HK subjects also had significantly lower HRQOL Z scores in domains of role limitations due to emotional or physical problems, and bodily pain. CD subjects had more social support, but had more difficulties in meeting medical costs, and were less likely to have regular medical follow-up and dysphagia symptom. After adjusting for social and health related factors, the site differences in handicap and the role limitation (physical) domain of SF36 became insignificant. Conclusions CD stroke survivors had better scores in HRQOL and fewer handicaps than their counterparts in HK, because of social and health related factors.
Assessing the Need for a Comprehensive Acne Quality-of-Life Scale for Face and Torso Acne
Authors: McLellan Chelsea , Frey Marc Philip , Tan Jerry 
Published: November 2017

Purpose: While acne, a common condition, largely involves the face, chest, and back, current acne quality-of-life measures focus primarily on facial acne. The purpose of this study was to assess the need for a comprehensive quality-of-life measure intended for use with patients who have facial and/or torso acne. Methods: We evaluated the need for a comprehensive quality-of-life scale for facial and torso acne based on data from an epidemiological survey (N = 690) in which participants were grouped according to the location of their acne (face, torso, or both) and where quality of life was assessed. Results: Analysis of variance results revealed that participants with acne on their torso reported the highest levels of quality of life while participants with acne on their face reported the lowest levels. Conclusions: There is a need for a quality-of-life instrument that assesses the impact of acne on the face and torso separately. This unmet need can be addressed with a comprehensive acne quality-of-life measure that is inclusive of torso acne.
Simplifying Logistics and Avoiding the Unnecessary in Patients With Breast Cancer Undergoing Sentinel Node Biopsy. A Prospective Feasibility Trial of the Preoperative Injection of Super Paramagnetic Iron Oxide Nanoparticles
Authors: Karakatsanis A. , Olofsson H. , Stålberg P. , Bergkvist L. , Abdsaleh S. , Wärnberg F. 
Published: November 2017

Purpose: Sentinel node is routinely localized with the intraoperative use of a radioactive tracer, involving challenging logistics. Super paramagnetic iron oxide nanoparticle is a non-radioactive tracer with comparable performance that could allow for preoperative localization, would simplify the procedure, and possibly be of value in axillary mapping before neoadjuvant treatment. The current trial aimed to determine the a priori hypothesis that the injection of super paramagnetic iron oxide nanoparticles in the preoperative period for the localization of the sentinel node is feasible. Methods: This is a prospective feasibility trial, conducted from 9 September 2014 to 22 October 2014 at Uppsala University Hospital. In all, 12 consecutive patients with primary breast cancer planned for resection of the primary and sentinel node biopsy were recruited. Super paramagnetic iron oxide nanoparticles were injected in the preoperative visit in the outpatient clinic. The radioactive tracer (99mTc) and the blue dye were injected perioperatively in standard fashion. A volunteer was injected with super paramagnetic iron oxide nanoparticles to follow the decline in the magnetic signal in the sentinel node over time. The primary outcome was successful sentinel node detection. Results: Super paramagnetic iron oxide nanoparticles’ detection after preoperative injection (3–15 days) was successful in all cases (100%). In the volunteer, axillary signal was presented for 4 weeks. No adverse effects were noted. Conclusion and relevance: Preoperative super paramagnetic iron oxide nanoparticles’ injection is feasible and leads to successful detection of the sentinel node. That may lead to simplified logistics as well as the identification, sampling, and marking of the sentinel node in patients planned for neoadjuvant treatment.
Development of the Spanish Language Houston Pain Outcome Instrument for Spanish Speakers
Authors: McNeill Jeanette , Sherwood Gwen 
Published: November 2017

Purpose: To address reported disparities in pain management among Hispanic patients, this article reports the psychometrics of the newly developed Spanish language Houston Pain Outcome Instrument (HPOI) with postoperative Hispanic patients. Methods: Findings from qualitative interviews conducted with 35 self-identified Hispanics in Phase 1 of the overall project were used to generate items for a new Spanish language instrument, Cuestionario de Houston Sobre el Dolor (HPOI). The second phase tested the psychometric properties with 95 self-identified Hispanic postoperative inpatients in three Texas hospitals. Results: HPOI subscale reliabilities ranged from .63 to .91, with similar reliabilities for Spanish and English versions. Concurrent validity was demonstrated by moderate significant correlations with similar items on the Brief Pain Inventory. Participants reported moderate and severe worst pain in the last 24 hours; 38% were undertreated for pain according to the Pain Management Index; and 75% reported nonpharmacologic strategies including family support, prayer, and position change as highly effective in managing pain. Conclusions: The HPOI is a reliable instrument for addressing disparities in pain management for the rapidly growing Hispanic population in the United States. Subscales for interference with mood and physical function and patient-reported nonpharmacologic strategies facilitate a more comprehensive assessment of the pain experience.
Influence of stroke coordinators on delivery of acute stroke care and hospital outcomes: An observational study
Authors: Purvis Tara , Kilkenny Monique F , Middleton Sandy , Cadilhac Dominique A 
Published: November 2017

Background Stroke coordinators have been inconsistently used in various countries to support stroke care in hospital. Aim To investigate the association between stroke coordinators and the provision of evidence-based care and patient outcomes in hospitals with acute stroke units. Methods Observational study using cross-sectional data from the 2015 National Acute Services Audit Program (Australia): including a retrospective medical record audit (40 records from each hospital) and a self-reported survey of organizational resources for stroke. Multilevel random effects logistic regression for patient outcomes including complications, independence on discharge, and death. Median regression for length of stay comparisons. Results A total of 109 hospitals submitted 4060 cases; 59 (54%) had a stroke coordinator. Compared with patients from stroke unit hospitals with no stroke coordinator ( N = 33, 1333 cases), patients in stroke unit hospitals with a stroke coordinator ( N = 53, 2072 cases) were more likely to receive clinical practices including rehabilitation therapy within 48 hours of initial assessment (88 vs. 82%, p < 0.001), risk factor modification advice (62 vs. 55%, p = 0.003) and receive a discharge care plan (65 vs. 48%, p < 0.001). No differences in complications, independence on discharge, or deaths were evident. Patients from hospitals with a stroke coordinator were more likely to access inpatient rehabilitation (adjusted odds ratio 1.8, 95% confidence interval 1.1–2.8) and have a reduced length of acute stay if discharged (median 14 h, p = 0.03). Conclusion Presence of stroke coordinators was associated with reduced length of stay and improved delivery of evidence-based care in hospitals with a stroke unit.
Cerebral amyloid angiopathy associated with inflammation: A systematic review of clinical and imaging features and outcome
Authors: Corovic Andrej , Kelly Siobhan , Markus Hugh S 
Published: November 2017

Background Cerebral amyloid angiopathy associated with inflammation is an increasingly recognized condition, characterized by an inflammatory response to the vascular deposits of β-amyloid within the brain that are the hallmark of cerebral amyloid angiopathy. Two main patterns of this inflammatory response have been identified to date: one involving a perivascular inflammatory cell infiltrate (cerebral amyloid angiopathy-related inflammation); the other a transmural vasculitic process (A-beta related angiitis). Unlike cerebral amyloid angiopathy itself, which predisposes to intracerebral hemorrhage and has no known treatment, cerebral amyloid angiopathy associated with inflammation typically presents in diverse ways and diagnosis may be challenging and delayed. Aims We sought to summarize the clinical features, imaging appearances and available data on outcome and treatment responses, using information derived from a systematic review of pathologically proven cases of cerebral amyloid angiopathy associated with inflammation. Summary of review We identified 213 distinct pathologically proven cases of cerebral amyloid angiopathy-related inflammation/A-beta related angiitis, from 104 publications. The clinical presentation, imaging features, pathology, treatment, and outcomes of cerebral amyloid angiopathy associated with inflammation are described. Conclusions Cerebral amyloid angiopathy associated with inflammation is an important and increasingly recognized clinical condition, which affects the older patient population and presents most commonly with cognitive decline, seizures, and headaches. Future research is required to develop and validate diagnostic criteria and determine optimum treatment strategies.