bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the Chemical Constituents of Rhodobryum roseum Based on UHPLC-Q-Exactive Orbitrap Mass Spectrometry
Authors: Yan Shen-long , Li Kai-lin , Yang Qing-rui , Yu Kai-quan , Liu Ling , Li Qing , Wen Lin-wen , Huang Cong , Li Hui , Liu Yan-nan 
Published: September 2024

Objective To further explore the unknown chemical composition and aimed to develop a reliable strategy for characterizing compounds in Rhodobryum roseum ( R. roseum). Methods This study employed an efficient, high-sensitivity, and high-resolution analysis method. The method utilized UHPLC-Q-Exactive Orbitrap MS, along with trace data acquisition mode (parallel reaction monitoring scanning, PRM), and multiple data processing methods. Results A total of 77 chemical substances were identified in R. roseum, including 16 amino acids, 33 organic acids including 6 aromatic acids, 8 phenolics compounds, 2 flavonoid glycosides, 4 flavonoids and 14 other compounds including 4 fatty alcohols by comparing with reference substances, secondary characteristic ion fragments, public databases, and literature. Among these, 74 compounds were found in this plant for the first time. Conclusion This result significantly expands the knowledge of the chemical constituents of R. roseum and contributes to the understanding of its active constituents for quality control.
Examining the Relationship Between Emotional Intelligence and Tacit Knowledge Sharing using a Moderated Mediation Model
Authors: Li Yu , Li Hao 
Published: September 2024

This study empirically tested that emotional intelligence as an important antecedent in tacit knowledge sharing through the mediating role of professional commitment as well as the moderating effect of perceived organizational support. A self-administrated questionnaire was employed to collect relevant data from employees working in knowledge-intensive and challenging industries such as IT, semiconductors, electronics, medicine, chemistry and biochemistry. The survey yielded a total of 278 effective responses, PROCESS package developed by Hayes was utilized to evaluate the hypotheses. Consistent with theoretical perspective gained from social exchange theory and self-determination theory, the results indicated that employees with higher level of emotional intelligence tend to have higher professional commitment toward the organization, which further fosters tacit knowledge sharing behavior. Prior research predominantly focused on team and organizational motivations and outcomes, relatively little knowledge is known about the link between individual characteristics and tacit knowledge sharing. The current study aims to contribute to knowledge management literature by addressing such research gap. Theoretical and practical implications were discussed in the last part. JEL Classification: M10, M12, O39.
Skill, Will, and Time: A Feasibility and Pilot Efficacy Study of Two Structured Interventions to Enhance Undergraduates’ Resilience Through Self-Regulation
Authors: Smart Colette M. , Chim Louise , Nicoll Patrick , Viczko Jeremy , Qualls Lauren K. 
Published: September 2024

The current study had two purposes: (1) to examine the feasibility and acceptability of two manualized intervention programs to enhance resilience through the mechanism of self-regulation in undergraduate students enrolled in Introductory Psychology, and (2) to examine preliminary efficacy of those interventions. Eligible participants were 445 undergraduates aged 18–25 years at a mid-size Canadian university during spring 2020, quasi-randomized to one of two 4-week self-regulation interventions taught via labs, focused on either “top-down” or “bottom-up” aspects of self-regulation, respectively. A total of N = 445 students provided data in the study, with 133 participants in interventions and 312 in the control group. Qualitative data indicated that the interventions were feasible and acceptable. Self-report measures of attention control, resilience, affect, and interoception, as well as exam scores, indicate dissociable effects for the two intervention conditions. As student mental health becomes an increasing concern, enhancing students’ well-being through primary prevention may prove to be a vital intervention focus.
Assessment of the Postoperative Progression in Patients With Intramedullary Spinal Cord Tumors Based on the Severity of Preoperative Gait Disturbance
Authors: Okubo Toshiki , Nagoshi Narihito , Iga Takahito , Takeda Kazuki , Ozaki Masahiro , Suzuki Satoshi , Matsumoto Morio , Nakamura Masaya , Watanabe Kota 
Published: September 2024

Study Design Retrospective comparative study. Objectives This study aimed to determine whether the severity of preoperative gait disturbance remains after surgical resection in patients with intramedullary spinal cord tumors (IMSCTs), and to identify any factors influencing poor improvement in postoperative gait disturbance. Methods The study included a total of 128 patients with IMSCTs requiring surgical excision between 2006 and 2019. Based on the degree of preoperative gait disturbance assessed by the modified McCormick scale (MMCS) grade, patients were categorized into Mild (I-II) and Severe (III-V) groups. The mean postoperative follow-up period was 55.5 ± 34.3 months, and demographic and surgical characteristics were compared between the two groups. Results Significant differences were observed in age at surgery, tumor location, tumor size, estimated blood loss, intraoperative motor-evoked potential disappearance, extent of resection, and tumor histopathology between the Mild and Severe groups. In the Mild group, at the final follow-up, only 7.3% of patients experienced improvement, 56.0% showed no changes, and 36.7% experienced deterioration. Conversely, in the Severe group, 26.3% of patients experienced improvement, 31.6% showed no changes, and 42.1% experienced deterioration. Tumor location and age at surgery were identified as factors correlated with poor improvement in postoperative gait disturbance in the Mild group. Conclusions Irrespective of the preoperative gait disturbance degree, approximately 40% of patients with IMSCTs experienced deterioration in gait after tumor resection. For preoperative MMCS grade I-II cases, older age at surgery and thoracic IMSCTs would be important factors associated with poor improvement in postoperative gait disturbance.
Death Café conversations: evaluating the educational potential for university students in palliative care teaching
Authors: Borque Ignacio , Oliete Elena , Arantzamendi María , Centeno Carlos 
Published: September 2024

Background: Discussing death, particularly among future healthcare professionals, remains a challenge. The “Death Café” initiative offers a relaxed setting for such conversations, and this study investigates its educational potential for medical students. Objectives: To assess the effectiveness of “Death Café” as an educational tool for medical students in palliative care, and to understand students’ perceptions and reflections on death and end-of-life topics post-participation. Design: An exploratory qualitative design was employed, analyzing reflections submitted by medical students following voluntary participation in a Death Café session. Methods: Medical students from a course on palliative care participated in the “Death Café,” a structured yet informal discussion about death in a relaxed café setting. Subsequently, participants submitted written reflections on their experiences. These reflections were analyzed using a thematic analysis method, identifying emerging themes related to the students’ perceptions of death, the event, and its impact on their future medical practice. Results: Forty-two students attended the Death Café. Twenty-one reflections were collected from 29 medical students who participated. Most students found the “Death Café” environment conducive to open conversations about death. Key themes included recognizing the fragility of life, the role of medical professionals in end-of-life care, and the personal and professional growth derived from such reflections. The students also highlighted the transformative nature of the event, shifting from discussing death in general to pondering on their roles as future healthcare professionals. Positive feedback indicated the absence of negative comments about the activity, with suggestions provided for future iterations. Conclusion: The “Death Café” serves as an innovative pedagogical approach to medical education, particularly in palliative care teaching. It offers students a platform for sincere dialogue on death and reinforces the significance of integrating innovative methods in medical training. This initiative not only enriches personal understanding but also emphasizes the commitment to holistic patient care.
Re-living trauma near death: an integrative review using Grounded Theory narrative analysis
Authors: Johnston Nikki , Chapman Michael , Gibson Jo , Paterson Catherine , Turner Murray , Strickland Karen , Liu Wai-Man , Phillips Christine , Bail Kasia 
Published: September 2024

Background: Symptoms of emotional and physical stress near death may be related to previous experiences of trauma. Objective: To investigate current evidence regarding the following: (1) Is previous trauma identified in people who are dying, and if so, how? (2) How is previous trauma associated with the experience of death/dying in people with or without cognitive impairment? and (3) What palliative care interventions are available to people with previous trauma at the end of life? Design: This integrative review was conducted per Whittemore and Knafl’s guidelines, which involves a stepped approach, specifically (1) problem identification, (2) literature search, (3) data evaluation, (4) data analysis and (5) presentation. Methods: This integrative review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Electronic databases were searched in August 2021 and updated in August 2023. The articles were quality appraised, and narrative data were analysed using Grounded Theory (GT). Results: Of 1310 studies screened, 11 met the inclusion criteria (four qualitative and seven quantitative) conducted in Australia, Canada, Japan and the United States; and American studies accounted for 7/11 studies. Eight were focused on war veterans. Descriptive studies accounted for the majority, with only two publications testing interventions. Re-living trauma near death has additional features to a diagnosis of post-traumatic stress disorder alone, such as physical symptoms of uncontrolled, unexplained acute pain and this distress was reported in the last weeks of life. Conclusion: This study proposes that re-living trauma near death is a recognisable phenomenon with physical and psychological impacts that can be ameliorated with improved clinical knowledge and appropriate management as a new GT. Further research is needed to enable past trauma identification at the end of life, and trauma-informed safe interventions at the end of life are an urgent need.
Patient Experience and Attitudes Toward Electronic Intake and Patient-Reported Outcomes Within an Outpatient Whole Health Center
Authors: Segall Tracy L , Rodgers-Melnick Samuel N , Surdam Jessica , Srinivasan Roshini , Dusek Jeffery A 
Published: September 2024

Background: The use of electronic intake forms within the electronic health record (EHR) is an emerging method for routinely collecting patient-reported outcomes (PRO). However, few studies have evaluated experiences/perspectives toward electronic forms among outpatients receiving care within Integrative Health and Medicine (IHM) clinics. The study purpose was to understand patients’ perspectives of electronic intake and PRO forms in the outpatient IHM setting. Methods: Electronic intake (e.g., treatment expectations, medical history, chief complaints, prior experience with integrative modalities) and PRO forms (i.e., Patient Reported Outcome Measurement Information System [PROMIS]-29, Perceived Stress Scale 4, Oswestry Disability Index) were designed in collaboration with clinic leadership and the Information Technology team. Semi-structured interviews were used to gather perspectives of the functionality and acceptability of the forms among outpatients receiving care at the IHM center. Interviews were coded to describe themes regarding perceptions and suggestions for improvement. Results: Qualitative interviews were completed with 10 participants (median age 51 years, 70% female, 30% Black/African American). Participants considered electronic intake and PRO forms as relevant to their health concerns, valuable for conveying important health information to providers, and easy to navigate. Suggested changes to the intake form included adding relevant open-ended questions, save and print functions, and examples and definitions to prompt responses. Conclusion: Participants felt the electronic format was a feasible and acceptable method of collecting patient information and PROs. Future goals are to implement the revised forms in a common EHR to patients receiving care at multiple IHM clinics across the United States.
‘You Can Die With Me But I Won’t Let You Live With Me’, Exploring Social Influences on the Continuation of Heroin Use in Men Who Use Heroin
Authors: Houghton Ben , Kouimtsidis Christos , Duka Theodora , Paloyelis Yannis , Bailey Alexis , Notley Caitlin 
Published: September 2024

Background: Heroin is a substance with a unique social profile in that it is commonly used by individuals alone but there is a paucity of qualitative research exploring how social influences impact the continuation of heroin use, particularly when people are trying to stop using heroin. This study explored social determinants which influence the continuation of heroin use in males in UK community treatment who use illicit heroin alongside opioid replacement therapy. Design: Participants were self-selecting from an initial purposively recruited sample. Using Janis (1972) 8 symptoms of Groupthink as an a priori framework for analysis, the study method utilised qualitative interviews with fourteen males. The discussions were digitally-recorded, transcribed verbatim, and analysed thematically. Findings: Contrasting with the evidence base, the sample included people who transitioned from recreational drug use to dependent heroin use without experiencing trauma of any kind. Far from becoming socially isolated when actively using heroin, interviews identified a shift in social networks from networks built on shared moments to networks underpinned by transactional exchange. Components of Groupthink were identified when participants described belonging to heroin using networks and continued to use heroin whilst trying to abstain though individual accountability was central to the decision to continue to use heroin. Conclusions: The conflict between the individual goal of abstinence and the group goal of continuation suggests that social network interventions could be more successful if delivered to cohorts of people who buy heroin together.
Integrating network pharmacology, molecular docking and experimental verification to explore the therapeutic effect and potential mechanism of nomilin against triple-negative breast cancer
Authors: Wu Zhixuan , Xiang Haoyi , Wang Xiaowu , Zhang Rongrong , Guo Yangyang , Qu Liangchen , Zhou Jingyao , Xiao Yanyi 
Published: September 2024

Abstract
Background
Nomilin is a limonoid compound known for its multiple biological activities, but its role in triple negative breast cancer (TNBC) remains unclear. This study aims to uncover the potential therapeutic effect of nomilin on TNBC and elucidate the specific mechanism of its action.

Methods
We employed weighted gene co-expression network analysis (WGCNA), differential expression analysis, and the GeneCards database to identify potential targets for TNBC. Simultaneously, we utilized the Swiss Target Prediction, ChEMBL, and STITCH databases to identify potential targets of nomilin. The core targets and mechanisms of nomilin against TNBC were predicted through protein-protein interaction (PPI) network analysis, molecular docking, and enrichment analysis. The results of the network pharmacology were corroborated by conducting experiments.

Results
A total of 17,204 TNBC targets were screened, and 301 potential targets of nomilin were identified. Through the PPI network, eight core targets of nomilin against TNBC were pinpointed, namely BCL2, Caspase3, CyclinD1, EGFR, HSP90AA1, KRAS, PARP1, and TNF. Molecular docking, molecular dynamics simulation and proteome microarray revealed that nomilin exhibits strong binding activity to these core proteins. Enrichment analysis results indicated that the anti-TNBC effect of nomilin is associated with PI3K/Akt pathway. In vitro and in vivo experiments have demonstrated that nomilin inhibits TNBC cell proliferation and migration while promoting cell apoptosis through the PI3K/Akt pathway.

Conclusion
For the first time, the research effectively discovered the objectives and mechanisms of nomilin in combating TNBC using network pharmacology, molecular docking, molecular dynamics simulation, proteome microarray and experimental confirmation, presenting a hopeful approach for treating TNBC.

Graphical Abstract
Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hematological diseases
Authors: Ma Shuangping , Qin Yiran , Ren Wenjie 
Published: September 2024

AbstractThe oncofetal mRNA-binding protein IGF2BP1 belongs to a conserved family of RNA-binding proteins. It primarily promotes RNA stability, regulates translation and RNA localization, and mediates gene expression through its downstream effectors. Numerous studies have demonstrated that IGF2BP1 plays crucial roles in embryogenesis and carcinogenesis. IGF2BP1-modulated cell proliferation, invasion, and chemo-resistance in solid tumors have attracted researchers’ attention. Additionally, several studies have highlighted the importance of IGF2BP1 in hematologic malignancies and hematological genetic diseases, positioning it as a promising therapeutic target for hematological disorders. However, there is a lack of systematic summaries regarding the IGF2BP1 gene within the hematological field. In this review, we provide a comprehensive overview of the discovery and molecular structure of IGF2BP1, along with recent studies on its role in regulating embryogenesis. We also focus on the mechanisms by which IGF2BP1 regulates hematological malignancies through its interactions with its targeted mRNAs. Furthermore, we systematically elucidate the function and mechanism of IGF2BP1 in promoting fetal hemoglobin expression in adult hematopoietic stem/progenitor cells. Finally, we discuss the limitations and challenges of IGF2BP1 as a therapeutic target, offering insights into its prospects.
Comparison of free vascularized fibular grafts and the Masquelet technique for the treatment of segmental bone defects with open forearm fractures: a retrospective cohort study
Authors: Zhou Ming , Ma Yunhong , Jia Xueyuan , Wu Yongwei , Liu Jun , Wang Yapeng , Wang Peng , Luo Junhao , Lin Fang , Wang Jianbing , Rui Yongjun 
Published: September 2024

Abstract
Purpose
Severe open forearm fractures commonly involve segmental bone defects. Although several methods have been proposed to treat segmental bone defects with such fractures, research comparing the radiological and clinical outcomes of free vascularized fibular grafts (FVFG) and the Masquelet technique (MT) is rare.

Methods
Data on 43 patients with open forearm fractures and segmental bone defects treated surgically in our hospital from January 2005 to January 2021 were retrospectively analyzed, and these patients were divided into an FVFG group (18 cases) and an MT group (25 cases). Clinical and radiological evaluations were performed regularly, and the minimum follow-up was 18 months.

Results
All 43 patients were followed up for 18 to 190 months, with a mean of 46.93 months. The mean follow-up time was significantly longer in the FVFG group than in the MT group (p = 0.000). Bone healing time was 3–16 months, with a mean of 4.67 months. The QuickDASH score at the last follow-up was 0–38.6, with a mean of 17.71, and there was no statistically significant difference between the two groups. Operative time, hospital stay, and intraoperative bleeding for bone defect reconstruction were higher in the FVFG group compared to the MT group (p = 0.000), whereas the number of procedures was lower in the FVFG group than in the MT group (p = 0.035).

Conclusions
FVFG and the MT showed satisfactory clinical results for segmental bone defects of the forearm. Compared with FVFG, the MT exhibited a lower operative time, hospital stay, and intraoperative bleeding.

Level of evidence
Level IV.
Trial registration This study was registered in the Chinese Clinical Trial Registry (registration no. ChiCTR2300067675; registered 17 January 2023), https://www.chictr.org.cn/showproj.html?proj=189458.
Epispadias, a correctable cause of structural infertility in a middle-aged man: a case report
Authors: Kura Mustapha , Abdulsalam Khalifa Ibrahim , Ayodeji Afolayan , Arogundade Abayomi , Ezekiel David 
Published: September 2024

Abstract
Background
Epispadias is a rare form of genito-urinary congenital anomaly and presentation in the middle-ages is even rarer. The reproductive outcome of treatment which was almost immediate, highlights the life changing effect of appropriate treatment for this condition in a middle-aged patient. We hereby report this rare case of a middle-aged man presenting with complete male epispadias with background infertility and the outcome of effective treatment. (Reviewer #1. Comment 1).

Case presentation
Our patient is a 54-year-old security guard who presented to our facility in February 2022 (Reviewer #1. Comment 3) with passage of urine from an abnormal opening since birth. Examination revealed a middle-aged man having ammoniacal smell. He had a spade like glans penis, ventral hooding, urethral meatus at the root of the penis dorsally with no chordee. He was diagnosed to have complete male epispadias (CME) for which he eventually had a modified Cantwell–Ransley procedure under general anaesthesia. About 3 months after the procedure, patient was able to impregnate his wife, a feat he will be achieving for the first time in his life.

Conclusions
The right treatment irrespective of age at presentation could significantly improve the quality of life of patients as evidenced by our patient whom after surgery was able to impregnate his wife for the first time at 54 years of age.