bluuebunny/crossref_metadata_2025_split huggingface dataset:
Binocular deprivation induces both age-dependent and age-independent forms of plasticity in parvalbumin inhibitory neuron visual response properties
Authors: Feese Berquin D. , Pafundo Diego E. , Schmehl Meredith N. , Kuhlman Sandra J. 
Published: November 2017

Activity of cortical inhibitory interneurons is rapidly reduced in response to monocular deprivation during the critical period for ocular dominance plasticity and in response to salient events encountered during learning. In the case of primary sensory cortex, a decrease in mean evoked firing rate of parvalbumin-positive (PV) inhibitory neurons is causally linked to a reorganization of excitatory networks following sensory perturbation. Converging evidence indicates that it is deprivation, and not an imbalance between open- and closed-eye inputs, that triggers rapid plasticity in PV neurons. However, this has not been directly tested in vivo. Using two-photon guided cell-attached recording, we examined the impact of closing both eyes for 24 h on PV neuron response properties in mouse primary visual cortex. We found that binocular deprivation induces a 30% reduction in stimulus-evoked mean firing rate and that this reduction is specific to critical period-aged mice. The number of PV neurons showing detectable tuning to orientation increased after 24 h of deprivation, and this effect was also specific to critical period-aged mice. In contrast to evoked mean firing rate and orientation tuning, measurements of trial-to-trial variability revealed that stimulus-driven decreases in variability are significantly dampened by deprivation during both the critical period and the postcritical period. These data establish that open-eye inputs are not required to drive deprivation-induced weakening of PV neuron evoked activity and that other aspects of in vivo PV neuron activity are malleable throughout life. NEW & NOTEWORTHY Parvalbumin-positive (PV) neurons in sensory cortex are generally considered to be mediators of experience-dependent plasticity, and their plasticity is restricted to the critical period. However, in regions outside of sensory cortex, accumulating evidence demonstrates that PV neurons are plastic in adults, raising the possibility that aspects of PV response properties may be plastic throughout life. Here we identify a feature of in vivo PV neuron activity that remains plastic past the critical period.
Control of saccadic latency in a dynamic environment: allocation of saccades in time follows the matching law
Authors: Vullings Cécile , Madelain Laurent 
Published: November 2017

When exploring the visual environment, one uses saccades to shift gaze and fixation to gather spatially and temporally localized information. We propose that the temporal structure of our environment should constrain the temporal allocation of saccades. Here we probe the possibility of learning to control saccadic latencies in a choice paradigm. Six participants made saccades within 80–300 ms following a target horizontally stepping by 10° between two fixed locations. For each participant we constructed two classes of latencies, “short” and “long,” using the first and last quartiles of the individual baseline distribution (e.g., [80;152] ms and [185;300] ms, respectively). We then concurrently reinforced each class in three blocked conditions across ~60 experimental sessions per participant, using different reinforcement probabilities such that the relative ratio of reinforcement rates for short vs. long latencies was 9/1, 1/9, or 1/1. Latency distributions followed the reinforcement conditions: distributions shifted toward the shorter or longer values or became strongly bimodal. Moreover, the relative rates of short over long latencies matched the relative rates of reinforcers earned for the corresponding latencies (slope up to 0.95), which reveals the ability to choose when to saccade. Our results reveal that learned contingencies considerably affect the allocation of saccades in time and are in line with recent studies on the temporal adjustment of behavior to dynamic environments. This study provides strong evidence for fine operant control of saccadic latency, supporting the hypothesis of a cost-benefit control of saccade latencies.NEW & NOTEWORTHY Saccades may be regarded as an information-foraging behavior mostly concerned with the spatial localization of objects, yet our world is dynamic and environmental temporal regularities should also affect saccade decisions. We present behavioral data from a choice task establishing that humans can learn to choose their saccadic latencies depending on the reinforcement contingencies. This suggests a cost-benefit-based policy that takes into account the learned temporal properties of the environmental contingencies for controlling saccade triggering.
Vestibular short-latency evoked potential abolished by low-frequency noise exposure in rats
Authors: Stewart Courtney E. , Kanicki Ariane C. , Altschuler Richard A. , King W. M. 
Published: November 2017

The vestibular system plays a critical role in detection of head movements and is essential for normal postural control. Because of their anatomical proximity to the cochlea, the otolith organs are selectively exposed to sound pressure and are at risk for noise overstimulation. Clinical reports suggest a link between noise exposure and balance problems, but the structural and physiological basis for this linkage is not well understood. The goal of this study was to determine the effects of low-frequency noise (LFN) on the otolith organs by correlating changes in vestibular short-latency evoked potentials (VsEPs) with changes in saccular afferent endings following noise exposure. LFN exposure transiently abolished the VsEP and reduced the number of stained calyces within the sacculus. Although some recovery of the VsEP waveform could be observed within 3 days after noise, at 3 wk recovery was only partial in most animals, consistent with a reduced number of afferents with calyceal endings. These data show that a single intense noise exposure is capable of causing a vestibular deficit that appears to mirror the synaptic deficit associated with hidden hearing loss after noise-induced cochlear injury. NEW & NOTEWORTHY This is the first study to explore the effects of low-frequency high-intensity noise on vestibular short-latency evoked potential (VsEP) responses, which shows a linkage between attenuated noise-induced VsEPs and pathological changes to otolith organ afferents. This finding suggests a potential limitation of the VsEP for evaluation of vestibular dysfunction, since the VsEP measurement may assess the activity of a specific class rather than all afferents.
MicroRNA‐130a, a Potential Antifibrotic Target in Cardiac Fibrosis
Authors: Li Li , Bounds Kelsey R. , Chatterjee Piyali , Gupta Sudhiranjan 
Published: November 2017

Background

Cardiac fibrosis occurs because of disruption of the extracellular matrix network leading to myocardial dysfunction. Angiotensin
II
has been implicated in the development of cardiac fibrosis. Recently, micro
RNA
s have been identified as an attractive target for therapeutic intervention in cardiac pathologies; however, the underlying mechanism of micro
RNA
s in cardiac fibrosis remains unclear. Micro
RNA
‐130a (miR‐130a) has been shown to participate in angiogenesis and cardiac arrhythmia; however, its role in cardiac fibrosis is unknown.

Methods and Results

In this study, we found that miR‐130a was significantly upregulated in angiotensin
II
‐infused mice. The in vivo inhibition of miR‐130a by locked nucleic acid– based anti‐miR‐130a in mice significantly reduced angiotensin
II
‐induced cardiac fibrosis. Upregulation of miR‐130a was confirmed in failing human hearts. Overexpressing miR‐130a in cardiac fibroblasts promoted profibrotic gene expression and myofibroblasts differentiation, and the inhibition of miR‐130a reversed the processes. Using the constitutive and dominant negative constructs of peroxisome proliferator‐activated receptor γ 3‐′untranslated region (UTR), data revealed that the protective mechanism was associated with restoration of peroxisome proliferator‐activated receptor γ level leading to the inhibition of angiotensin
II
‐induced cardiac fibrosis.

Conclusions
Our findings provide evidence that miR‐130a plays a critical role in cardiac fibrosis by directly targeting peroxisome proliferator‐activated receptor γ. We conclude that inhibition of miR‐130a would be a promising strategy for the treatment of cardiac fibrosis.
Resistance of the S1 layer in kempas heartwood fibers to soft rot decay
Authors: Singh Adya P. , Wong Andrew H.H. , Kim Yoon Soo , Wi Seung Gon 
Published: November 2017

Naturally durable heartwoods, where available, continue to be used as support structures in environments considered hazardous, particularly in ground contact. However, durability of heartwoods against wood decay microorganisms varies. Therefore, it is important to evaluate heartwood products for their in-service performance in order to maximise benefits derived from this valuable natural resource of limited supply. In the work presented, wood pieces from a kempas (Koompassia malaccensis) utility pole that had been placed in service in an acidic soil in Malaysia, and in time had softened at the ground-line position, were examined by light and transmission electron microscopy to evaluate the cause of deterioration.Light microscopy (LM) provided evidence of extensive attack on fibre cell walls by cavity-producing soft rot fungi. Transmission electron microscopy (TEM) revealed in greater detail the distribution and micromorphologies of cavities as well as their relationships to the fine structure of fibre cell walls, which consisted of a highly electron dense middle lamella, a moderately dense S1 layer and a multilamellar S2 layer with variable densities, reflecting differences in lignin concentration. The resistance of the moderately dense S1 layer to soft rot was a feature of particular interest and is the main focus of the work presented. The resistance appeared to be correlated with high lignification of the outermost region of the S2 wall, interfacing with the S1 layer, an unusual cell wall feature not previously described for normal wood.
Young people’s perceptions of the objective physical activity monitoring process: A qualitative exploration
Authors: Scott Joseph J , Hansen Vibeke , Morgan Philip J , Plotnikoff Ronald C , Lubans David R 
Published: November 2017

Objective: To explore young people’s perceptions of pedometers and investigate behaviours exhibited while being monitored. Design: Qualitative design using six focus groups with participants (mean age 14.7 years). Setting: Study participants ( n = 24) were randomly selected from a previous study of 123 young people aged 14–15 years from three secondary schools in New South Wales (NSW), Australia. Methods: Participants wore pedometers (Yamax CW700) and accelerometers (ActiGraph GT3X+) simultaneously for 7 days. Accelerometer output was used to categorise participants into one of six focus groups (three boys groups and three girls groups): (1) low active (<30 minutes moderate to vigorous physical activity [MVPA]/day), (2) medium active (30–60 minutes MVPA/day), and (3) high active (≥60 minutes MVPA/day). Participants were questioned on their perceptions of the monitoring process and the behaviours that they exhibited while wearing pedometers. A hybrid approach to data analysis identified key concepts, which were thematically analysed. Results: The two main themes identified were (1) participants’ perceptions of the monitoring process and (2) behaviour exhibited while being monitored. Overall, participants’ attitudes towards objective monitoring were positive. A large proportion reported changing their levels of physical activity during the monitoring process, and 87.5% of focus group participants reported shaking their pedometers to increase their step counts. The medium and high active groups reported changing their activity patterns more than the low active groups. Conclusion: Our findings are consistent with previous quantitative studies that suggest reactivity and tampering are commonplace among young people. Pedometers may have more utility as an intervention strategy for increasing activity rather than as a method for assessing habitual activity levels.
The grounded theory of “trust building”
Authors: Ramezani Monir , Ahmadi Fazlollah , Mohammadi Eesa , Kazemnejad Anoshirvan 
Published: November 2017

Background: Despite the growing importance of spiritual care, the delivery of spiritual care is still an area of disagreement among healthcare providers. Objective: To develop a grounded theory about spiritual care delivery based on Iranian nurses’ perceptions and experiences. A grounded theory approach: A qualitative study using the grounded theory approach. Participants and research context: Data were collected through holding 27 interviews with 25 participants (17 staff nurses, 3 physicians, 3 patients, 1 family member, and 1 nurse assistant). The study setting was the Imam Khomeini Hospital Complex. Sampling was started purposively and continued theoretically. Data analysis was performed by the method proposed by Strauss and Corbin. Ethical consideration: The study was approved by the Ethics Committee of Tarbiat Modares University and the agreement of the administrators of the study setting was got before starting the study. Results: The core category of the study was “Trust building” which reflected the nature of spiritual care delivery by nurses. Trust building was the result of eight main categories or strategies including creating a positive mentality at hospital admission, understanding patients in care circumstances, having a caring presence, adhering to care ethics, developing meaningful relationships, promoting positive thinking and energy, establishing effective communication with patients, and attempting to create a safe therapeutic environment. Poor interprofessional coordination negatively affected this process while living toward developing greater cognizance of divinity and adhering to the principles of professional ethics facilitated it. The outcome of the process was to gain a sense of partial psychological security. Conclusion: The “Trust building” theory can be used as a guide for describing and expanding nurses’ roles in spiritual care delivery, developing care documentation systems and clinical guidelines, and planning educational programs for nursing students and staff nurses.
Clastogenic Factors as Potential Biomarkers of Increased Superoxide Production
Authors: Emerit Ingrid 
Published: November 2017

The formation of clastogenic factors (CF) and their damaging effects are mediated by superoxide, since superoxide dismutase is regularly protective. CF are produced via superoxide and stimulate the production of superoxide by monocytes and neutrophils. This results in a selfsustaining and longlasting process of clastogenesis, which may exceed the DNA repair system and ultimately lead to cancer (Emerit, 1994). An increased cancer risk is indeed observed in conditions accompanied by CF formation. These include irradiated persons, patients with chronic inflammatory diseases, HIV-infected persons and the chromosomal breakage syndromes ataxia telangiectasia, Bloom's syndrome and Fanconi's anemia. Biochemical analysis has identified lipid peroxidation products, arachidonic acid metabolites, nucleotides of inosine and cytokines, in particular tumor necrosis factor alpha, as the clastogenic and also superoxide stimulating components of CF. Due to their chromosome damaging effects, these oxidants can be detected with classical cytogenetic techniques. Their synergistic action renders the CF-test particularly sensitive for the detection of a pro-oxidant state. Correlations were observed between CF and other biomarkers of oxidative stress such as decreases in total plasma thiols or increases in TBARS or chemiluminescence. Correlations between CF and disease activity, between CF and radiation exposure, suggest the study of CF for monitoring these conditions. CF may also be useful as biochemical markers and intermediate endpoints for the evaluation of promising antioxidant drugs.CF formation represents a link between chronic inflammation and carcinogenesis. Prophylactic use of superoxide scavengers as anticarcinogens is therefore suggested.
Alteration of Transthyretin Microheterogeneity in Serum of Multiple Trauma Patients
Authors: Gericke Beate , Raila Jens , Deja Maria , Rohn Sascha , Donaubauer Bernd , Nagl Britta , Haebel Sophie , Schweigert Florian J. , Kaisers Udo 
Published: November 2017

Transthyretin (TTR) which exists in various isoforms, is a valid marker for acute phase response and subclinical malnutrition. The aim of the study was to investigate the relationship between inflammation, oxidative stress and the occurrence of changes in microheterogeneity of TTR. A prospective, observational study at a level-I trauma center of a large urban medical university was performed. Patients were severely injured (n = 18; injury severity score (ISS): 34–66), and were observed within the first 24 hours of admittance and over the following days until day 20 after injury. 20 healthy subjects, matched by age and sex, were used as controls. TTR was enriched by immunoprecipitation. Microheterogeneity of TTR was determined by linear matrix assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS). Four major mass signals were observed for TTR representing native, S-cysteinylated, S-cysteinglycinylated and S-glutathionylated TTR. In the course of their ICU stay, 14 of the 18 patients showed a transient change in microheterogeneity in favour of the S-cysteinglycinylated form of TTR (p < 0.05 vs. controls). The occurrence of this variant was not associated with the severity of trauma or the intensity of the acute-phase response, but was associated with oxidative stress as evidenced by Trolox. Our results demonstrate that changes in microheterogeneity of TTR occur in a substantial number of ICU trauma patients. The diagnostic values of these changes remains to be elucidated. It is speculated that TTR modification may well be the mechanism underlying the morphological manifestation of amyloidose or Alzheimer's diseases in patients surviving multiple trauma.
Low Cardiac Output Syndrome After Adult Cardiac Surgery: Predictive Value of Peak Systolic Global Longitudinal Strain
Authors: Amabili Philippe , Benbouchta Sabeha , Roediger Laurence , Senard Marc , Hubert Marie Bernard , Donneau Anne-Françoise , Brichant Jean-François , Hans Gregory A. 
Published: November 2017

BACKGROUND:
Peak systolic global longitudinal strain (GLS) is increasingly used to quantify left ventricular systolic function. The primary objective of this study was to assess whether GLS obtained during intraoperative transesophageal echocardiogram, performed before cardiopulmonary bypass, improves the prediction of postoperative low cardiac output syndrome (LCOS) after adult cardiac surgery.

METHODS:
GLS from 275 patients undergoing on-pump cardiac surgery was calculated retrospectively using two-dimensional– speckle tracking echocardiography (aCMQ module from Qlab software version 10.5, Philips Medical, Brussels, Belgium). LCOS was defined as the need for inotropic or mechanical circulatory support for >24 hours postoperatively. Patient and procedure characteristics associated with LCOS at the univariable level (P ≤ .05) were entered into a forward stepwise logistic regression to create a first predictive model. A second model was created by adding GLS. The 2 models were compared using the likelihood-ratio test, the area under the receiver operating characteristic (ROC) curve, and the integrated discrimination index. The optimal cutoff value of GLS associated with LCOS was determined by maximizing the Youden index of the ROC curve. Secondary outcomes included time until complete weaning from inotropes, discharge from the intensive care unit and from the hospital, and 30-day mortality.

RESULTS:
GLS was significantly associated with LCOS (P < .001) at the univariable level. Predictors of LCOS retained in the first model were cardiopulmonary bypass duration, decreased left ventricular ejection fraction, mitral valve surgery, and New York Heart Association functional class III or IV. Adding the GLS value improved the prediction of LCOS (P = .02). However, the area under the ROC curve did not differ between the 2 models (0.83; 95% confidence interval [CI], 0.77–0.99 vs 0.84; 95% CI, 0.79–0.90; P = .15). The integrated discrimination index associated with addition of GLS was 0.02 (P = .046), meaning that the difference in predicted risk between patients with and without LCOS increased by 2% after adding GLS. A GLS cutoff value of −17% (95% CI, −18.8% to −15.3%) was found to best identify LCOS. After adjusting for covariates included in model 1, a lower GLS value was significantly associated with a lower cumulative probability of weaning from inotropes postoperatively (hazard ratio, 0.90; 95% CI, 0.82–0.97; P = .01). No association was found between GLS and other secondary outcome measures.

CONCLUSIONS:
GLS is an independent predictor of LCOS after on-pump cardiac surgery. Its incremental value over other established risk factors for postoperative LCOS is, however, limited.
Improved solid adult diet for the olive fruit fly, Dacus oleae
Authors: Tsitsipis J.A. , Kontos Α. 
Published: November 2017

Egg production of the olive fruit fly, Dacus oleae (Gmelin) (Diptera: Tephritidae), was higher when insects fed on a liquid diet than on the same diet made solid by enriching it with various amounts of cellite or cellulose. Comparison of a liquid with a solid diet, both composed of water: sucrose: yeast hydrolyzate: chicken egg yolk at ratios 5:4: 1:0.7 and 0:4: 1:0.7 respectively, given to olive fruit flies kept in pairs, showed that egg production was higher on the liquid diet. With grouped insects, however (30 pairs per cage), egg production. expressed per initial female, was higher with the solid diet. The difference was due to the lower mortality that occurred on the solid diet. Dry egg yolk could substitute fresh egg yolk. Among solid diets differing in the concentration of egg yolk, yeast hydrolyzate, and the presence of vitamins and cholesterol, the diet that gave the highest egg production contained 80 parts sucrose, 30 parts yeast hydrolyzate, and 6.6 parts dry egg yolk.
Catches of male olive moths, Prays oleae, in pheromone traps in relation to numbers of eggs and larvae found in olive fruits, in Crete
Authors: Polyrakis Ι. 
Published: November 2017

In two groves of the Chania area, male olive moths, Prays oleae (Bernard) (Lepidoptera: Hyponomeutidae), caught in pheromone traps and eggs and young larvae in young fruits were counted weekly or daily in May, June and July. At Mournies, the first rise in the curve of male captures was observed during the last week of May with a maximum on the 18th in 1980 and on the 10th of June in 1981, and the last captures at the end of June-beginning of July. At Chrysopigi, the maximum of captures in 1981 was on the 5th of June. In all instances the time of maximal moth captures coincided with peaks in oviposition activity, followed after an interval of two weeks by peaks in the number of young larvae found in the fruits.
Key for the identification of the instars of the English grain aphid, Sitobion αvenαe (F.) (Hemiptera: Aphididae)
Authors: Lykouressis D.Ρ 
Published: November 2017

A key is given for the identification of the instars of the English grain aphid, Sitobion avenae (F.) based upon morphological characters of the antennae, cauda and sub-anal plate.