bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficient Delivery of Gold Nanoparticles and miRNA-33a Via Cationic PEGylated Niosomal Formulation to MCF-7 Breast Cancer Cells
Authors: Ahmadi Seyedeh Melika , Seyedabadi Mohammad , Ebrahimnejad Pedram , Abasi Mozhgan , Nokhodchi Ali 
Published: September 2024

AbstractTo overcome the challenges associated with the co-delivery of AuNPs (gold nanoparticles) and miRNA as an anti-breast cancer combination therapy, niosomal systems were developed using Span 60, cholesterol, and a cationic lipid (CTAB), and the formulations were optimized using Box-Behnken experimental design. The niosomal formulations with the smallest size were selected for further optimization of size, surface charge, entrapment efficiency, and stability. To achieve this, AuNPs and DSPE-PEG2000 (2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000)were added to the formulation. The optimized niosomal formulation could effectively encapsulate AuNPs with an entrapment efficiency of 34.49% ± 0.84 and a spherical particle size of 153.6 ± 4.62 nm. The incorporation of PEG and CTAB led to notable enhancements in the overall characteristics of the delivery system. To evaluate the effectiveness of the combination therapy, various assessments such as cytotoxicity, apoptosis, and gene expression properties were conducted. The results demonstrated that the combination delivery using the new C-PEG-Nio-AuNPs (cationic pegylated niosomal gold nanoparticles) system and miRNA had the lowest IC50, the highest apoptosis rate, and the most significant upregulation of miRNA and BAX/BCL2 expression in MCF-7 cell growth. In conclusion, this innovative co-delivery approach represents a promising breakthrough in the development of therapeutic agents for breast cancer treatment. By combining multiple therapeutic agents within a single delivery system, this method has the potential to enhance treatment efficacy, reduce side effects, and improve patient outcomes.
Graphical Abstract
Social and auditory experience shapes forebrain responsiveness in zebra finches before the sensitive period of vocal learning
Authors: Schroeder Katie M. , Remage-Healey Luke 
Published: September 2024

ABSTRACT
Early-life experiences with signals used in communication are instrumental in shaping an animal's social interactions. In songbirds, which use vocalizations for guiding social interactions and mate choice, recent studies show that sensory effects on development occur earlier than previously expected, even in embryos and nestlings. Here, we explored the neural dynamics underlying experience-dependent song categorization in young birds prior to the traditionally studied sensitive period of vocal learning that begins around 3 weeks post-hatch. We raised zebra finches either with their biological parents, cross-fostered by Bengalese finches beginning at embryonic day 9, or with only the non-singing mother from 2 days post-hatch. Then, 1–5 days after fledging, we conducted behavioral experiments and extracellular recordings in the auditory forebrain to test responses to zebra finch and Bengalese finch songs. Auditory forebrain neurons in cross-fostered and isolated birds showed increases in firing rate and decreases in responsiveness and selectivity. In cross-fostered birds, decreases in responsiveness and selectivity relative to white noise were specific to conspecific song stimuli, which paralleled behavioral attentiveness to conspecific songs in those same birds. This study shows that auditory and social experience can already impact song ‘type’ processing in the brains of nestlings, and that brain changes at this age can portend the effects of natal experience in adults.
A Dynamic Matching Mechanism for College Admissions: Theory and Experiment
Authors: Gong Binglin , Liang Yingzhi 
Published: September 2024

Market design provides managerial insights into the success and failure of various market institutions in allocating scarce resources. We investigate a dynamic matching mechanism used in real-world college admissions, where students share a common priority ranking. Theoretically, we prove that efficient and stable matching occurs with an arbitrarily high probability, assuming sufficient revision opportunities and rationality. This predicts that the dynamic mechanism is less stable than the deferred acceptance mechanism and less efficient than the Boston mechanism. We confirm this prediction in a low-complexity laboratory setting. However, in a high-complexity setting, the dynamic mechanism matches the stability of the deferred acceptance and the efficiency of the Boston mechanism, as both underperform in this setting. This finding indicates that the dynamic mechanism is more resilient to increased complexity. We attribute this resilience to its belief-independent characterization of rationalizable strategies. Beyond college admissions, the dynamic mechanism has potential applications in housing assignments, job allocations, and ascending auctions. This paper was accepted by Axel Ockenfels, decision analysis. Funding: B. Gong gratefully acknowledges financial support from National Science Foundation of China [Grant 72373041], Major Project of Shanghai Education Commission’s Research and Innovation Program [Grant 2023ZKZD05-79]; Fundamental Research Funds for the Central Universities [Grant 2022QKT004]. Y. Liang is particularly thankful for the Barbour Scholarship’s financial support during her doctoral studies at the University of Michigan while working on this paper. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00871 .
A Comprehensive Guide to Removable Partial Dentures. Part 2: Impressions, Laboratory Procedures, Insertion and Case Studies
Authors: Nooji Deviprasad , Lambourn Guy , Aggarwal Himanshi , Salian Kiran Kumar Krishnappa , McColl Ewen , Eachempati Prashanti 
Published: September 2024

This two-part series provides a comprehensive guide to fabricating definitive metal partial dentures, addressing the challenges dental practitioners face in mastering prosthesis design. It aims to equip dental professionals with a thorough understanding of the theoretical foundations and clinical methods for effective metal partial denture fabrication. Part 2 covers removable partial denture (RPD) design philosophies, tooth preparation, secondary impressions, laboratory procedures, trial and final insertions, as well as post-insertion complications and their management. Additionally, four case scenarios are included to help readers apply the knowledge gained from both parts to design a metal partial denture. CPD/Clinical Relevance: This series provides essential knowledge and practical techniques for designing and fabricating effective metal partial dentures.
Semiconductor laser collimation and shaping design based on the combination of a rotationally symmetrical lens and a cylindrical lens
Authors: Zhong Liang , Li Yunlong , Fu Shuaikang , Qin Yan , Liu Jianing , Jiang Ping , Yang Huajun 
Published: September 2024

A dual-lens collimation and shaping system which is composed of a rotationally symmetric lens and an aspherical cylindrical lens is proposed in this paper. The system design method is discussed in detail, and the divergent elliptical laser beams are finally converted into collimated circular beams. The simulation results show that the maximum divergence angle of the beams can be collimated to 2.58 µrad, the standard deviation of the edge beam radius samples (SDRS) can be decreased from the original 4.227 to 0.135 mm, and the ratio of beam waist (RBW) drops from 1.554 to 1.0093 in the case of the output beam radius of 40 mm. The effects of transmission distance, astigmatism, wavelength deviation, light source offset, and lens offset on the collimation shaping effect are discussed. The collimation system can be widely used in long-distance optical communication systems and the design method in this paper can provide some new ideas for optical design researchers.
Investigating ethical tradeoffs in crisis standards of care through simulation of ventilator allocation protocols
Authors: Herington Jonathan , Shand Jessica , Holden-Wiltse Jeanne , Corbett Anthony , Dees Richard , Ching Chin-Lin , Shaw Margie , Cai Xueya , Zand Martin 
Published: September 2024

Introduction
Arguments over the appropriate Crisis Standards of Care (CSC) for public health emergencies often assume that there is a tradeoff between saving the most lives, saving the most life-years, and preventing racial disparities. However, these assumptions have rarely been explored empirically. To quantitatively characterize possible ethical tradeoffs, we aimed to simulate the implementation of five proposed CSC protocols for rationing ventilators in the context of the COVID-19 pandemic.

Methods
A Monte Carlo simulation was used to estimate the number of lives saved and life-years saved by implementing clinical acuity-, comorbidity- and age-based CSC protocols under different shortage conditions. This model was populated with patient data from 3707 adult admissions requiring ventilator support in a New York hospital system between April 2020 and May 2021. To estimate lives and life-years saved by each protocol, we determined survival to discharge and estimated remaining life expectancy for each admission.

Results
The simulation demonstrated stronger performance for age-sensitive protocols. For a capacity of 1 bed per 2 patients, ranking by age bands saves approximately 29 lives and 3400 life-years per thousand patients. Proposed protocols from New York and Maryland which allocated without considering age saved the fewest lives (~13.2 and 8.5 lives) and life-years (~416 and 420 years). Unlike other protocols, the New York and Maryland algorithms did not generate significant disparities in lives saved and life-years saved between White non-Hispanic, Black non-Hispanic, and Hispanic sub-populations. For all protocols, we observed a positive correlation between lives saved and life-years saved, but also between lives saved overall and inequality in the number of lives saved in different race and ethnicity sub-populations.

Conclusion
While there is significant variance in the number of lives saved and life-years saved, we did not find a tradeoff between saving the most lives and saving the most life-years. Moreover, concerns about racial discrimination in triage protocols require thinking carefully about the tradeoff between enforcing equality of survival rates and maximizing the lives saved in each sub-population.
MULT: An allometric body mass index (ABMI) reference to assess nutritional status of multiethnic children and adolescents
Authors: de Oliveira Mariane Helen , Mazzeti Camila Medeiros da Silva , Araújo Joana , Severo Milton , Ramos Elisabete , Rodrigues Kévin Allan Sales , Pereira Débora Borges dos Santos , Conde Wolney Lisboa 
Published: September 2024

Objectives
To develop an allometric body mass index (ABMI) reference that adjusts the weight in relation to height, taking into account the changes during development (MULT ABMI reference), and to compare it with international BMI references.

Methods
The MULT ABMI reference was constructed through the LMS method, calculated with 65 644 ABMI observations of 17 447 subjects aged 5–22 years, from the United Kingdom, Ethiopia, India, Peru, Vietnam, Portugal, and Brazil. The M, S, and L curves of the MULT ABMI reference were compared with the curves of the MULT, World Health Organization (WHO), Centers for Disease Control and Prevention (CDC), International Obesity Task Force (IOTF), and Dutch Growth Study (DUTCH).

Results
The greater differences in the M curve between MULT ABMI and WHO, CDC, IOTF, DUTCH, and MULT BMI references were around puberty (138 to 150 months for boys; 114 to 132 for girls). MULT ABMI presented S values similar to IOTF and DUTCH BMI references for boys 60 to 114 months and then became higher, approaching the MULT BMI S values from 198 to 240 months. For girls the MULT ABMI S values were close to the IOTF, CDC, and DUTCH from 60 to 110 months, and then became higher, approaching the MULT BMI S values until 240 months.

Conclusion
MULT ABMI presented an advantage in comparison to the existing BMI references because it takes into account the growth changes during puberty and is a new option to assess the nutritional status of multiethnic populations.
Identifying and prioritising barriers to injury care in Northern Malawi, results of a multifacility multidisciplinary health facility staff survey
Authors: Whitaker John , Njawala Taniel , Nyirenda Vitumbeku , Amoah Abena S. , Dube Albert , Chirwa Lindani , Munthali Boston , Rickard Rory , Leather Andrew J. M. , Davies Justine 
Published: September 2024

Introduction
The burden of injuries globally and in Malawi is substantial. Optimising both access to, and quality of, care in health systems requires attention. We aimed to establish how health facility staff in Karonga, Malawi, perceive barriers to seeking (delay 1), reaching (delay 2) and receiving (delay 3) injury care.

Method
We conducted a cross-sectional survey of health facility staff who treat patients with injuries in all health facilities serving the Karonga Demographic Surveillance Site population. The primary outcome was participant perceptions of the importance of delays 1 to 3 following injury. Secondary outcomes were the barriers within each of these delays considered most important and which were considered the most important across all delays stages.

Results
228 staff completed the survey: 36.8% (84/228) were female and 61.4% (140/228) reported being involved in caring for an injured person at least weekly. Delay 3 was most frequently considered the most important delay 35.1% (80/228), with 19.3% (44/228) and 16.6% (38/228) reporting delays 1 and 2 as the most important respectively; 28.9% (66/228) of respondents either did not know or answer. For delay 1 the barrier, “the perceived financial costs associated with seeking care are too great”, was considered most important. For delay 2, the barrier “lack of timely affordable emergency transport (formal or informal)” was considered most important. For delay 3, the barrier, “lack of reliably available necessary physical resources (infrastructure, equipment and consumable material)” was considered most important. When considering the most important overall barrier across all delays, the delay 3 barrier, “lack of reliably available necessary physical resources” received the most nominations (41.7% [95/228]).

Conclusions
Given the awareness of health facility staff of the issues facing their patients, these findings should assist in informing health system planning.
Uptake and associated factors of six multi-month scripting/appointment spacing differentiated service delivery model of care among stable clients on antiretroviral therapy in Southern Ethiopia
Authors: Merid Fasika , Guyo Tamirat Gezahegn , Wagaye Simegn , Mekuria Mesele , Anbesie Abraham , Toma Temesgen Mohammed 
Published: September 2024

Background
Differentiated service delivery models have been developed to accommodate the rising number of stable antiretroviral therapy clients and to maintain improvements in health outcomes and care retention. Ethiopia adopted the appointment spacing model and has had notable successes in implementing it. However, with the implementation of the six multi-month scripting/appointment spacing model in Ethiopia, little is known about the uptake and its associated factors. Therefore, this study aimed to assess the uptake and associated factors of the six multi-month scripting/appointment spacing differentiated service delivery model of care among stable clients on antiretroviral therapy in Southern Ethiopia.

Methods
A hospital-based cross-sectional study was conducted among 419 stable clients on antiretroviral therapy in southern Ethiopia from June 22 to September 29, 2023. A systematic sampling technique was used to select the study participants. Using a structured questionnaire, socio-demographic, health service delivery, behavioral, and clinical-related data were collected. The collected data were entered into Epi Data version 3.1 and analyzed using Stata version 14. Variables with a P-value <0.05 in the multivariable logistic analysis were considered statistically significant. Multicollinearity and model fitness were checked using the variance inflation factor and the Hosmer and Lemeshow goodness of fit tests, respectively.

Results
The uptake of the six multi-month scripting/appointment spacing differentiated service delivery model of care was 63.25% (95% confidence interval (CI): 58.61%, 67.88%). Missed appointment (Adjusted Odds Ratio (AOR): 1.91 (95% CI: 1.13, 3.25)), distance to antiretroviral therapy facility (AOR: 2.90 (95% CI: 1.67, 5.04)), duration on antiretroviral therapy (AOR: 2.21 (95% CI: 1.34, 3.64)), and intermediate social support (AOR: 2.02 (95% CI: 1.29, 3.17)) and strong social support (AOR: 2.71 (95% CI: 1.23, 5.97)) were factors significantly associated with the uptake.

Conclusion
The uptake of six multi-month scripting/appointment spacing differentiated service delivery models of care was six out of ten clients on antiretroviral therapy. To further improve the uptake, a precise intervention on the identified associated factor is required.
Coproducción de conocimiento entre equipos de investigación universitarios y profesores de escuela secundaria
Authors: Freytes Frey Ada Cora 
Published: September 2024

Este artículo discute el caso de una investigación colaborativa internacional llevada adelante por dos equipos de investigadores universitarios y docentes de escuela secundaria, uno en el Área Metropolitana de Buenos Aires, Argentina y otro en Medellín, Colombia. El objetivo de la investigación fue: reconstruir y analizar, a través de sus narrativas, las experiencias que profesores y estudiantes desarrollan en torno a la inclusión, la construcción de paz y la ciudadanía en escuelas medias que atienden a jóvenes en situación de vulnerabilidad social, en el Área Metropolitana de Buenos Aires y en Medellín.
La investigación articuló una perspectiva hermenéutico-comprensiva, sobre la base de las narrativas, con una perspectiva crítica, a partir de la inclusión de elementos de investigación acción, de larga tradición en el campo educativo. En efecto, se trabajó colaborativamente con 4 escuelas, 2 de Argentina y 2 de Colombia. En cada una de ellas, de 2 a 3 profesores se incorporaron al equipo de investigación, participando desde las primeras fases de formulación del proyecto hasta el análisis de resultados. El texto reflexiona acerca de los problemas y logros experimentados en el proceso de investigación colaborativa. También presenta algunos de los principales resultados obtenidos, en términos de producción de conocimiento.
Las expectativas a futuro de jóvenes del último año de la escuela secundaria
Authors: Kummer Virginia Marta 
Published: September 2024

Este trabajo se inscribe en una investigación que indaga las expectativas a futuro, los sentidos sobre la educación y el trabajo de jóvenes del último año de escuela secundaria de la ciudad de Paraná, capital de la provincia de Entre Ríos, en el período comprendido entre los años 2023-2024.
Tiene como objetivo dar cuenta de las decisiones teórico-metodológicas adoptadas sobre la construcción de los datos –la elección de un cuestionario como instrumento de obtención de información- y el procedimiento para la selección, la estructura y el tamaño de la muestra. El estudio fue realizado en 22 escuelas secundarias –orientadas y técnico-profesionales- de gestión estatal y privada de la ciudad de Paraná, a un total de 559 estudiantes. A nivel metodológico, la investigación contempla un diseño multidimensional que, además de la opinión de los estudiantes, analiza la política educativa y las estrategias institucionales para la preparación para el egreso.
miR‐495 promotes intestinal epithelial cell apoptosis through downregulation of Sphingosine‐1‐phosphate
Authors: Li Ruiyun , Cairns Cassandra , Yu Ting‐Xi , Jaladanki Rao , Dodson Claire M. , Chung Hee Kyoung , Xiao Lan , Wang Jian‐Ying , Turner Douglas J. 
Published: September 2024

AbstractMany pathological conditions lead to defects in intestinal epithelial integrity and loss of barrier function; Sphingosine‐1‐phosphate (S1P) has been shown to augment intestinal barrier integrity, though the exact mechanisms are not completely understood. We have previously shown that overexpression of Sphingosine Kinase 1 (SphK1), the rate limiting enzyme for S1P synthesis, significantly increased S1P production and cell proliferation. Here we show that microRNA 495 (miR‐495) upregulation led to decreased levels of SphK1 resultant from a direct effect at the SphK1 mRNA. Increasing expression of miR‐495 in intestinal epithelial cells resulted in decreased proliferation and increased susceptibility to apoptosis. Transgenic expression of miR‐495 inhibited mucosal growth, as well as decreased proliferation in the crypts. The intestinal villi also expressed decreased levels of barrier proteins and exaggerated damage upon exposure to cecal ligation‐puncture. These results implicate miR‐495 as a critical negative regulator of intestinal epithelial protection and proliferation through direct regulation of SphK1, the rate limiting enzyme critical for production of S1P.
Spatially-constrained Keypoint Matching for Efficient Statistical Shape Modelling
Authors: Harkämper Lena , Großbröhmer Christoph , Himstedt Marian 
Published: September 2024

Abstract
Statistical shape models (SSMs) allow the compact description of the variability of object shapes within a given sample set. They are commonly used in medical imaging to model and analyse the shape of anatomical structures such as organs. The generation of a SSM mainly consists of the calculation of the average shape and the main directions of variation of the data set. Usually, structured point clouds are used as shape representations. A crucial step in the calculation of the average shape of the data set represents the transformation of the objects into a common reference space in order to average coordinates of corresponding points. When using unstructured point clouds without explicitly defined landmarks, the matching of correspondences remains a challenge. We propose a novel solution for a spatially-constrained keypoint matching (FPFH++). It is based on a first attempt of a feature-based registration using Fast Point Feature Histograms (FPFH) compared to a baseline approach utilizing Coherent Point Drift (CPD).
Feasibility and accuracy of CARLO© guided extradural anterior clinoidectomy
Authors: Tu Ha Thanh , Schicker Martina , Luder Yann , Morawska Marta , Cordier Dominik , Röthlisberger Michel 
Published: September 2024

Abstract
Anterior clinoidectomy is a surgical procedure used to access the central skull base, providing access to sellar and parasellar pathologies and vascular lesions in and around the cavernous sinus. However, the procedure is challenging and risky due to limited working space, restricted surgical view, and proximity to critical anatomical structures such as the carotid artery, oculomotor nerve, and optic nerve.