bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive value of C‐reactive protein for tuberculosis, bloodstream infection or death among HIV‐infected individuals with chronic, non‐specific symptoms and negative sputum smear microscopy
Authors: Bedell Richard A. , van Lettow Monique , Meaney Christopher , Corbett Elizabeth L. , Chan Adrienne K. , Heyderman Robert S. , Anderson Suzanne T. , Åkesson Ann , Kumwenda Moses , Zachariah Rony , Harries Anthony D. , Ramsay Andrew R. 
Published: December 2017

AbstractBackgroundC‐reactive protein (CRP) is an inflammatory biomarker that may identify patients at risk of infections or death. Mortality among HIV‐infected persons commencing antiretroviral therapy (ART) is often attributed to tuberculosis (TB) or bloodstream infections (BSI).MethodsIn two district hospitals in southern Malawi, we recruited HIV‐infected adults with one or more unexplained symptoms present for at least one month (weight loss, fever or diarrhoea) and negative expectorated sputum microscopy for TB. CRP determination for 452 of 469 (96%) participants at study enrolment was analysed for associations with TB, BSI or death to 120 days post‐enrolment.ResultsBaseline CRP was significantly elevated among patients with confirmed or probable TB (52), BSI (50) or death (60) compared to those with no identified infection who survived at least 120 days (269). A CRP value of >10 mg/L was associated with confirmed or probable TB (adjusted odds ratio 5.7; 95% CI 2.6, 14.3; 87% sensitivity) or death by 30 days (adjusted odds ratio 9.2; 95% CI 2.2, 55.1; 88% sensitivity). CRP was independently associated with TB, BSI or death, but the prediction of these endpoints was enhanced by including haemoglobin (all outcomes), CD4 count (BSI, death) and whether ART was started (death) in logistic regression models.ConclusionHigh CRP at the time of ART initiation is associated with TB, BSI and early mortality and so has potential utility for stratifying patients for intensified clinical and laboratory investigation and follow‐up. They may also be considered for empirical treatment of opportunistic infections including TB.
HEAT RESISTANT AND TENSILE PROPERTIES OF GLASS FIBER REINFORCED POLYMER COMPOSITES
Authors: Ahmad Norhayati , Rasman Mohd Saufi , Wan Hussin Wan Nazdah 
Published: December 2017

The study focuses on E glass fiber laminate with vinyl ester resin. Two types of fiber glass are used namely chopped strand mat (CSM) and woven roving (WR). The objective of this research is to determine the thermal conductivity, specific heat capacity and Modulus Young of glass fiber-reinforced polymer (GFRP) prepared by vacuum bagging resin infusion process. The samples of GFRP were exposed to cooking gas fire for 5 minutes and 10 minutes for fire test. The tensile test was also conducted for the three samples and the microstructure was analyzed using Scanning Electron Microscope (SEM) after tensile testing. The result discovered that WR sample was better than CSM sample because CSM sample yield an average value of 0.236 W/mK for thermal conductivity and 521.6 J/KgK for specific heat capacity while WR sample give a value of 0.205 W/mK for thermal conductivity and 589.5 J/KgK for specific heat capacity. The Modulus Young of WR sample is higher (24.2 GPa) compared with CSM sample (16.1 GPa). From SEM micrograph, the failure occurred on the samples were matrix cracking and fibers separation. From the fire and tensile test conducted, the damage occurred on the samples were quite the same with the failure of the reinforcement and matrix. The findings could be used in the building construction as engineers always looking for the best material as they may have the possibilities of fire exposure and tension load as well as this is a part of the safety requirement for buildings.
Heat-not-burn tobacco product use in Japan: its prevalence, predictors and perceived symptoms from exposure to secondhand heat-not-burn tobacco aerosol
Authors: Tabuchi Takahiro , Gallus Silvano , Shinozaki Tomohiro , Nakaya Tomoki , Kunugita Naoki , Colwell Brian 
Published: December 2017

ObjectivesA heat-not-burn (HNB) tobacco product, IQOS, was first launched in Japan and Italy as test markets and is currently in commerce in 30 countries. Using two data sources, we examined interest in HNB tobacco (IQOS, Ploom and glo), its prevalence, predictors of its use and symptoms from exposure to secondhand HNB tobacco aerosol in Japan, where HNB tobacco has been sold since 2014.MethodsPopulation interest in HNB tobacco was explored using Google search query data. Prevalence of HNB tobacco current use (ie, use in the previous 30 days) was calculated using a longitudinal internet survey of 8240 individuals (15–69 years old in 2015) followed up to 2017. Rates of perceived symptoms from exposure to exhaled aerosol of others’ HNB tobacco were also calculated.ResultsThe largest internet search volume for IQOS occurred in April 2016 in the week after a popular national entertainment TV show introduced IQOS. For Ploom and glo, search volumes have remained limited since their launch. Prevalence of IQOS users increased from 0.3% in January–February 2015 to 0.6% in January–February 2016 and up to 3.6% in January–February 2017, while estimated rates of use of other HNB tobacco products remained low in 2017. Respondents who had seen the TV programme in 2016 were more likely to have used IQOS than those who had not seen it (10.3% vs 2.7%). Among never-smokers who had been exposed to secondhand HNB tobacco aerosol, nearly half reported at least one acute symptom, although these symptoms were not serious.ConclusionsA popular TV programme triggered IQOS diffusion in Japan. Extrapolating from survey results to the general population, around 3.1 million people currently use IQOS in Japan. Tobacco control organisations and governments should closely monitor HNB tobacco and consider how to regulate it.
Marshaling the Translational Potential ofMC1Rfor Precision Risk Assessment of Melanoma
Authors: Kanetsky Peter A. , Hay Jennifer L. 
Published: December 2017

AbstractMelanoma rates have been increasing in the United States, and neither primary (sun protection and avoidance) nor secondary (skin examination) prevention is practiced consistently, even by those with melanoma risk factors. Inherited variation at MC1R is a robust marker for increased risk of melanoma, even among individuals with “sun-resistant” phenotypes. Although MC1R conveys important information about inherited melanoma risk for a broad spectrum of individuals, concerns that MC1R feedback could have negative consequences, including increased distress about melanoma, inappropriate use of health services, and development of a false sense of security, are valid and require empirical examination. The time is right for high-quality research focusing on the translation of MC1R genotype into clinical and public health practice. If studies show MC1R genetic risk screening is effective at motivating behavior change, more melanomas may be detected at earliest stages for which surgical excision is highly curative or a large number of melanomas may be prevented altogether. While other genetic markers for melanoma susceptibility may emerge in the coming years, the burgeoning research agenda on the public health translational potential of MC1R genetic risk screening will inform and usefully advance current and future precision risk assessment of melanoma. Cancer Prev Res; 11(3); 121–4. ©2017 AACR.
Hemodynamics of Fontan Failure
Authors: Egbe Alexander C. , Connolly Heidi M. , Miranda William R. , Ammash Naser M. , Hagler Donald J. , Veldtman Gruschen R. , Borlaug Barry A. 
Published: December 2017

Background
Nonpulsatile pulmonary blood flow in Fontan circulation results in pulmonary vascular disease, but the potential relationships between pulmonary vascular resistance index (PVRI) and Fontan failure have not been studied. The objective was to determine whether the absence of subpulmonary ventricle in the Fontan circulation would make patients more vulnerable to even low-level elevations in PVRI, and when coupled with low cardiac index, this would identify patients at increased risk of Fontan failure.

Methods and Results

Two hundred sixty-one adult Fontan patients underwent cardiac catheterization; age 26±3 years, men 146 (56%), atriopulmonary Fontan 144 (55%). Patients were divided into 2 groups: those with high PVRI (>2 WU·m
2
) and low cardiac index <2.5 L min
−1
m
−2
(group 1, n=70, 30%), and those with normal PVRI and normal cardiac index (group 2, n=182, 70%). Fontan failure was defined by the composite of all-cause mortality, listing for heart transplantation, or initiation of palliative care. There were 68 (26%) cases of Fontan failure during a mean follow-up of 8.6±2.4 years. When compared with group 2, freedom from Fontan failure was significantly lower in group 1: 66% versus 89% at 5 years. The combination of high PVRI and low cardiac index was an independent risk factor for Fontan failure (hazard ratio, 1.84; 95% confidence interval, 1.09–2.85).

Conclusions
When coupled with low cardiac index, even mild elevations in PVRI identify patients at high risk of Fontan failure. This suggests that pulmonary vascular disease is a key mechanism underlying Fontan failure and supports further studies to understand the pathophysiology and target treatments to pulmonary vascular tone in this population.
Outcomes of Saphenous Vein Graft Intervention With and Without Embolic Protection Device
Authors: Paul Timir K. , Bhatheja Samit , Panchal Hemang B. , Zheng Shimin , Banerjee Subhash , Rao Sunil V. , Guzman Luis , Beohar Nirat , Zhao David , Mehran Roxana , Mukherjee Debabrata 
Published: December 2017

Background—
Current guidelines give a class I recommendation to use of embolic protection devices (EPD) for saphenous vein graft (SVG) intervention; however, studies have shown conflicting results. The objective of this meta-analysis is to compare all-cause mortality, major adverse cardiovascular events, myocardial infarction (MI), or target vessel revascularization in SVG intervention with and without EPD.

Methods and Results—

Literature was searched through October 2016. Eight studies (n=52 893) comparing SVG intervention performed with EPD (n=11 506) and without EPD (n=41 387) were included. There was no significant difference in all-cause mortality (odds ratio [OR], 0.79; confidence interval [CI], 0.55–1.12;
P
=0.19), major adverse cardiovascular events (OR, 0.73, CI, 0.51–1.05;
P
=0.09), target vessel revascularization (OR, 1.0; CI, 0.95–1.05;
P
=0.94), periprocedural MI (OR, 1.12; CI, 0.65–1.90,
P
=0.69), and late MI (OR, 0.80; CI, 0.52–1.23;
P
=0.30) between the 2 groups. Sensitivity analysis excluding CathPCI Registry study showed no difference in periprocedural MI, late MI, and target vessel revascularization; however, it favored EPD use in all-cause mortality and major adverse cardiovascular events. Further sensitivity analysis including only observational studies revealed no difference in all-cause mortality, major adverse cardiovascular events, target vessel revascularization, and late MI. Additional analysis after excluding CathPCI Registry study revealed no difference in outcomes.

Conclusions—
This study including 52 893 patients suggests no apparent benefit in routine use of EPD during SVG intervention in the contemporary real-world practice. Further randomized clinical trials are needed in current era to evaluate long-term outcomes in routine use of EPD, and meanwhile, current guideline recommendations on EPD use should be revisited.
Assessing Infant Carriage Systems: Ground Reaction Force Implications for Gait of the Caregiver
Authors: Brown Mathew B. , Digby-Bowl Caroline J. , Todd Samuel D. 
Published: December 2017

Objective To assess the acute alterations of anterior infant carriage systems on the ground reaction force experienced during over-ground walking. Background Previous research has identified the alterations in posture and gait associated with an increased anterior load (external or internal); however, the forces applied to the system due to the altered posture during over-ground walking have not been established. Method Thirteen mixed gender participants completed 45 over-ground walking trials at a self-selected pace under three loaded conditions (unloaded, semi-structured carrier 9.9 kg, and structured carrier 9.9 kg). Each trial consisted of a 15-m walkway, centered around a piezoelectric force platform sampling at 1,200 Hz. Differences were assessed between loaded and unloaded conditions and across carriers using paired samples t tests and repeated measures ANOVA. Results Additional load increased all ground reaction force parameters; however, the magnitude of force changes was influenced by carrier structure. The structured carrier displayed increased force magnitudes, a reduction in the time to vertical maximum heel contact, and an increased duration of the flat foot phase in walking gait. Conclusion Evidence suggests that the acute application of anterior infant carriers alters both kinetic and temporal measures of walking gait. Importantly, these changes appear to be governed not solely by the additional mass but also by the structure of the carrier. Application These findings indicate carrier structure should be considered by the wearer and may be used to inform policy in the recommendation of anterior infant carriage systems use by caregivers.
Older Adult Multitasking Performance Using a Gaze-Contingent Useful Field of View
Authors: Ward Nathan , Gaspar John G. , Neider Mark B. , Crowell James , Carbonari Ronald , Kaczmarski Hank , Ringer Ryan V. , Johnson Aaron P. , Loschky Lester C. , Kramer Arthur F. 
Published: December 2017

Objective We implemented a gaze-contingent useful field of view paradigm to examine older adult multitasking performance in a simulated driving environment. Background Multitasking refers to the ability to manage multiple simultaneous streams of information. Recent work suggests that multitasking declines with age, yet the mechanisms supporting these declines are still debated. One possible framework to better understand this phenomenon is the useful field of view, or the area in the visual field where information can be attended and processed. In particular, the useful field of view allows for the discrimination of two competing theories of real-time multitasking, a general interference account and a tunneling account. Methods Twenty-five older adult subjects completed a useful field of view task that involved discriminating the orientation of lines in gaze-contingent Gabor patches appearing at varying eccentricities (based on distance from the fovea) as they operated a vehicle in a driving simulator. In half of the driving scenarios, subjects also completed an auditory two-back task to manipulate cognitive workload, and during some trials, wind was introduced as a means to alter general driving difficulty. Results Consistent with prior work, indices of driving performance were sensitive to both wind and workload. Interestingly, we also observed a decline in Gabor patch discrimination accuracy under high cognitive workload regardless of eccentricity, which provides support for a general interference account of multitasking. Conclusion The results showed that our gaze-contingent useful field of view paradigm was able to successfully examine older adult multitasking performance in a simulated driving environment. Application This study represents the first attempt to successfully measure dynamic changes in the useful field of view for older adults completing a multitasking scenario involving driving.
A National Police Service: Any Day Now?
Authors: Donnelly Daniel , Scott Kenneth B. , Wilkie Roy 
Published: December 2017

Policing in the UK is moving towards more central control than ever before in its history, at the expense of a strong tripartite system, which seems to exist in name only. The evolving national network in England and Wales has a statutory foundation, while Scotland has adopted a mainly nonstatutory approach to central control, although this should change with new legislation in 2003. The potential for further centralisation in Scotland remains high because of the nation's size and new devolved constitutional position. The key question for all concerned in the UK, and particularly in Scotland, is what system of policing do we wish to have: a national service; a regional system; or the status quo? The answer can be found only after open public debate takes place.
Legitimacy and Public-Sector Quality: How Citizens Judge the Quality of the Police
Authors: De Vries M.S. 
Published: December 2017

The legitimacy of the Dutch police is under strain. On the one hand, citizens claim that safety has become one of the most important problems in the Netherlands whilst, on the other hand, they criticise government in general and the police in particular for being unable to realise a safe society. During the previous decade, several initiatives were developed in order to relegitimise the actions of the police by improving police performance. Community policing was introduced in order to increase both the effectiveness and availability of the police. This article theoretically and empirically explores the criteria citizens use to judge the police. This article illustrates the discrepancy between the wishes and demands of citizens and the way in which public-sector organizations, such as the police, try to satisfy citizens.
The Motorist from Abroad
Authors: Stanley C. R. 
Published: December 2017

Increasing numbers of motor vehicles from abroad, with their attendant problems, are travelling on our roads today. The advent of the European Common Market, which now affects the use of commercial motor vehicles here, makes it necessary that every police officer should have some knowledge of the legal position in this respect. It is part of the function of THE POLICE JOURNAL to publish useful information which is not available elsewhere and our readers will be grateful for the research made by the author of this article.
Risk Factor Knowledge, Perceived Threat, and Protective Health Behaviors: Implications for Type 2 Diabetes Control in Rural Communities
Authors: Paige Samantha R. , Bonnar Kelly K. , Black David R. , Coster Daniel C. 
Published: December 2017

Purpose The purpose of this study was to explore how perceived threat of type 2 diabetes (T2D) is shaped by risk factor knowledge and promotes the engagement of protective health behaviors among rural adults. Methods Participants (N = 252) completed a cross-sectional mixed-mode survey. Chi-squared analyses were computed to examine differences in perceived threat by demographic factors and knowledge of T2D risk factors. Logistic regressions were conducted to examine the relationship between T2D perceived threat and engagement in physical activity and health screenings. Results Perceived threat and knowledge of T2D risk factors were high. Perceived susceptibility was significantly higher among women, whites, and respondents with high body mass index (BMI). Respondents reporting physical activity most/almost every day had low perceived susceptibility to T2D. Perceived severity was significantly higher among respondents with high BMI. Blood cholesterol and glucose screenings were associated with greater T2D perceived susceptibility and severity. Higher BMI was associated with receiving a blood glucose screening. Conclusion Health education specialists and researchers should further explore the implications of using audience segmented fear appeal messages to promote T2D control through protective health behaviors.
Variation in Pediatric Organ Donor Management Practices Among US Organ Procurement Organizations
Authors: Ream Robert S. , Armbrecht Eric S. 
Published: December 2017

Introduction: Reports of actual pediatric organ donor management practice among US organ procurement organizations are sparse, and the use of standardized management guidelines is unknown. A recent consensus statement from the Society of Critical Care Medicine, the American College of Chest Physicians, and the Association of Organ Procurement Organizations offers guidelines for the management of the pediatric organ donor. Research Question: To describe the use of guidelines and routine practices in the management of the pediatric organ donor with respect to hemodynamics, lung and ventilator management, fluid and electrolytes, hormonal replacement therapy, the use of blood products, thermoregulation, and prophylactic antibiotics. Design: Cross-sectional observational study using a survey and follow-up telephone interview with respondents from all 58 US organ procurement organizations. Results: All 58 US Organ Procurement Organizations participated. A majority employed written guidelines for the management of pediatric donor hemodynamics, thermoregulation, fluids, and electrolytes. Management of blood products, the lung, and mechanical ventilation were less commonly committed to written guidelines, but common practices were described. All used various forms of hormonal replacement therapy and the majority administered empiric antibiotic therapy. Wide variation was observed in the management of the lung, mechanical ventilation, and glycemic control. Discussion: Most OPOs used forms of standardized donor management for the pediatric organ donor although variation in the content of that management exists. Barriers to an evidence-based approach to the pediatric donor need to be determined and addressed.