bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non–Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies
Authors: Stinchcombe Thomas E. , Zhang Ying , Vokes Everett E. , Schiller Joan H. , Bradley Jeffrey D. , Kelly Karen , Curran Walter J. , Schild Steven E. , Movsas Benjamin , Clamon Gerald , Govindan Ramaswamy , Blumenschein George R. , Socinski Mark A. , Ready Neal E. , Akerley Wallace L. , Cohen Harvey J. , Pang Herbert H. , Wang Xiaofei 
Published: May 2017

PurposeConcurrent chemoradiotherapy is standard treatment for patients with stage III non–small-cell lung cancer. Elderly patients may experience increased rates of adverse events (AEs) or less benefit from concurrent chemoradiotherapy.Patients and MethodsIndividual patient data were collected from 16 phase II or III trials conducted by US National Cancer Institute–supported cooperative groups of concurrent chemoradiotherapy alone or with consolidation or induction chemotherapy for stage III non–small-cell lung cancer from 1990 to 2012. Overall survival (OS), progression-free survival, and AEs were compared between patients age ≥ 70 (elderly) and those younger than 70 years (younger). Unadjusted and adjusted hazard ratios (HRs) for survival time and CIs were estimated by single-predictor and multivariable frailty Cox models. Unadjusted and adjusted odds ratio (ORs) for AEs and CIs were obtained from single-predictor and multivariable generalized linear mixed-effect models.ResultsA total of 2,768 patients were classified as younger and 832 as elderly. In unadjusted and multivariable models, elderly patients had worse OS (HR, 1.20; 95% CI, 1.09 to 1.31 and HR, 1.17; 95% CI, 1.07 to 1.29, respectively). In unadjusted and multivariable models, elderly and younger patients had similar progression-free survival (HR, 1.01; 95% CI, 0.93 to 1.10 and HR, 1.00; 95% CI, 0.91 to 1.09, respectively). Elderly patients had a higher rate of grade ≥ 3 AEs in unadjusted and multivariable models (OR, 1.35; 95% CI, 1.07 to 1.70 and OR, 1.38; 95% CI, 1.10 to 1.74, respectively). Grade 5 AEs were significantly higher in elderly compared with younger patients (9% v 4%; P < .01). Fewer elderly compared with younger patients completed treatment (47% v 57%; P < .01), and more discontinued treatment because of AEs (20% v 13%; P < .01), died during treatment (7.8% v 2.9%; P < .01), and refused further treatment (5.8% v 3.9%; P = .02).ConclusionElderly patients in concurrent chemoradiotherapy trials experienced worse OS, more toxicity, and had a higher rate of death during treatment than younger patients.
Systematic and general method for quantifying localization in microscopy images
Authors: Sheng Huanjie , Stauffer Weston , Lim Han N. 
Published: May 2017

ABSTRACTQuantifying the localization of molecules with respect to other molecules, cell structures and intracellular regions is essential to understanding their regulation and actions. However, measuring localization from microscopy images is often difficult with existing metrics. Here, we evaluate a metric for quantifying localization termed the threshold overlap score (TOS), and show it is simple to calculate, easy to interpret, able to be used to systematically characterize localization patterns, and generally applicable. TOS is calculated by: (i) measuring the overlap of pixels that are above the intensity thresholds for two signals; (ii) determining whether the overlap is more, less, or the same as expected by chance, i.e. colocalization, anti-colocalization, or non-colocalization; and (iii) rescaling to allow comparison at different thresholds. The above is repeated at multiple threshold combinations to generate a TOS matrix to systematically characterize the relationship between localization and signal intensities. TOS matrices were used to identify and distinguish localization patterns of different proteins in various simulations, cell types and organisms with greater specificity and sensitivity than common metrics. For all the above reasons, TOS is an excellent first line metric, particularly for cells with mixed localization patterns.
Strain-specific differences of the effects of stress on memory in Lymnaea
Authors: Hughes Emily , Shymansky Tamila , Swinton Erin , Lukowiak Kai S. , Swinton Cayley , Sunada Hiroshi , Protheroe Amy , Phillips Iain , Lukowiak Ken 
Published: May 2017

ABSTRACT
Stress alters the ability to form, recall and maintain memory according to the Yerkes–Dodson/Hebb (YDH) law. The effects of environmentally relevant stressors, such as low environmental calcium and crowding, on learning and memory have previously been described in a laboratory-reared ‘average’ strain of Lymnaea stagnalis (i.e. the Dutch strain) as well as two strains of freshly collected L. stagnalis with enhanced memory formation abilities (i.e. ‘smart’ snails). Here, we use L. stagnalis to study the effects of other environmentally relevant stressors on memory formation in two other strains of freshly collected snails, one ‘smart’ and one ‘average’. The stressors we examined are thermal, resource restriction combined with food odour, predator detection and, for the first time, tissue injury (shell damage). We show that the same stressor has significantly different effects on memory formation depending on whether snails are ‘smart’ or ‘average’. Specifically, our data suggest that a stressor or a combination of stressors act to enhance memory in ‘average’ snails but obstruct memory formation in ‘smart’ snails. These results are consistent with the YDH law and our hypothesis that ‘smart’ snails are more easily stressed than ‘average’ snails.
Intertidal oysters reach their physiological limit in a future high-CO2 world
Authors: Scanes Elliot , Parker Laura M. , O'Connor Wayne A. , Stapp Laura S. , Ross Pauline M. 
Published: May 2017

ABSTRACT
Sessile marine molluscs living in the intertidal zone experience periods of internal acidosis when exposed to air (emersion) during low tide. Relative to other marine organisms, molluscs have been identified as vulnerable to future ocean acidification; however, paradoxically it has also been shown that molluscs exposed to high CO2 environments are more resilient compared with those molluscs naive to CO2 exposure. Two competing hypotheses were tested using a novel experimental design incorporating tidal simulations to predict the future intertidal limit of oysters in a high-CO2 world; either high-shore oysters will be more tolerant of elevated PCO2 because of their regular acidosis, or elevated PCO2 will cause high-shore oysters to reach their limit. Sydney rock oysters, Saccostrea glomerata, were collected from the high-intertidal and subtidal areas of the shore and exposed in an orthogonal design to either an intertidal or a subtidal treatment at ambient or elevated PCO2, and physiological variables were measured. The combined treatment of tidal emersion and elevated PCO2 interacted synergistically to reduce the haemolymph pH (pHe) of oysters, and increase the PCO2 in the haemolymph (Pe,CO2) and standard metabolic rate. Oysters in the intertidal treatment also had lower condition and growth. Oysters showed a high degree of plasticity, and little evidence was found that intertidal oysters were more resilient than subtidal oysters. It is concluded that in a high-CO2 world the upper vertical limit of oyster distribution on the shore may be reduced. These results suggest that previous studies on intertidal organisms that lacked tidal simulations may have underestimated the effects of elevated PCO2.
A Matheuristic for the Multivehicle Inventory Routing Problem
Authors: Archetti Claudia , Boland Natashia , Grazia Speranza M. 
Published: May 2017

We consider the inventory routing problem, in which a supplier has to replenish a set of customers by means of a limited fleet of capacitated vehicles over a discrete time horizon. The goal is to minimize the total cost of the distribution that comprises the inventory cost at the supplier and at the customers and the routing cost. We present a matheuristic that combines a tabu search and mathematical programming formulations. When compared with two exact methods on 640 small instances, the matheuristic finds 192 (48%) optima over the 402 instances with known optima and improves 125 upper bounds. Tested on 240 large instances (with up to 200 customers) for which no optimal solutions are known, it improves the best solution for 220 (92%) of the 240 instances. The online supplement is available at https://doi.org/10.1287/ijoc.2016.0737 .
Greater Mutual Aggravation
Authors: Ebert Sebastian , Nocetti Diego C. , Schlesinger Harris 
Published: May 2017

A large strand of research has identified when (i) a single risk is undesirable and (ii) two independent risks aggravate each other. We extend this line of inquiry by establishing when (iii) mutual aggravation is greater for greater risks. This natural property of greater mutual aggravation explains recent experimental findings on higher-order risk preferences, and can guide managerial behavior when risks in the decision environment become more severe. The online appendix is available at https://doi.org/10.1287/mnsc.2017.2746 . This paper was accepted by Han Bleichrodt, decision analysis.
Inferior results with unilateral compared with bilateral brace in Ponseti-treated clubfeet
Authors: Sætersdal C. , Fevang J. M. , Engesæter L. B. 
Published: May 2017

Purpose The Ponseti method for treating clubfoot was introduced in Norway in 2003, and a cohort of children has been followed for 8 to 11 years. In a previous study, we found good results after follow-up of two to five years, with 3% rate of extensive surgery (posterior release or posteromedial release). During 8 to 11 years of follow-up, the rate of extensive surgery increased to 11%. The children had been treated with a bilateral brace or a unilateral brace. In this multicentre study we aimed to compare these two post-corrective treatment methods. Methods In all, 94 children (133 feet) were initially treated according to the Ponseti method, and had post-corrective treatment with either a bilateral foot abduction brace or a unilateral above-the-knee brace. The children were examined at a mean age of 9.3 years (8 to 11) regarding flexibility and deformity of the foot and ankle. Information including type of brace, brace compliance and surgical procedures was ­obtained from the patient records. The parents answered questionnaires and radiographs were taken of the feet. Results Feet treated with a bilateral brace had better dorsal flexion (p = 0.008), plantar flexion (p = 0.02), external rotation (p = 0.001) and less forefoot adduction (p = 0.04) than feet treated with a unilateral brace. Children using a bilateral brace had a better Functional Rating System score (p = 0.005) and Disease Specific Instrument score (p = 0.02). Conclusion Children treated with a bilateral brace had better parent-reported outcomes and more flexible feet than children treated with a unilateral brace. Our results do not support the use of a unilateral foot abduction brace in clubfoot treatment.
MARGINAL MATERIAL EVALUATION AND SELECTION USING ANALYTIC HIERARCHY PROCESS MODEL
Authors: Li Wentao , Wilson Doug J , Larkin Tam J 
Published: May 2017

Marginal materials, also called sub-standard materials, have the potential to replace premium materials in local roads. However, the current definition of marginal materials suffers from the limitation of focusing on whether or not each single property meets the corresponding requirement of specifications rather than reflecting the overall performance of the materials. To overcome this limitation and to better understand the concept of ‘marginal material’, this study was conducted using the Analytic Hierarchy Process (AHP) framework to evaluate the overall performance of five aggregates and an assumed boundary aggregate based on multiple factors (various engineering properties and performance). The aggregates were ranked through comparing the overall weight of each material, which was obtained based on the analysis of the relative weights of criteria and sub-criteria along with data processing of engineering properties.The AHP model is a good method to select the best aggregates within a number of given aggregates. It can describe the overall performance of aggregates in a quantitative way, which allows the qualities of the aggregates to be compared to each other so that the proper aggregates can be selected for different road construction purposes. The validation of the AHP model demonstrates that the AHP analyzed qualities of the aggregates match well to their qualities in field road construction, but there is a need to make a combination analysis on the individual properties (specification pass/fail criteria) and overall performance (AHP model) in the process of evaluating the quality of aggregates.https://doi.org/10.13022/ijahp2017.v9.is1.358
EVALUATING HEALTHCARE ORGANIZATIONS BY A NETWORK MODEL WHICH INTEGRATES ANP WITH A REVISED-BSC
Authors: Marcarelli Gabriella 
Published: May 2017

The evaluation of healthcare organizations is complex due to the trade-offs between all healthcare features, benefits and costs to consider and the great number of stakeholders involved. Each healthcare policy is multidimensional and its criteria are both objective and subjective in nature, so multicriteria methods are appropriate decision-making tools for a general manager in the evaluation process. This paper proposes to evaluate the strategic policies of an Italian Healthcare Organization by means of the Analytic Network Process (ANP) integrated with a revised Balanced Scorecard (r-BSC) approach. This integrated network model allows one to take into account the micro-macro organizational setting opportunities and some normative constraints and incentives, typical of the Italian health context. So, it may be useful not only to rank strategic policies and derive priorities for perspectives, objectives and metrics involved in a strategic map, but also to assign a performance index to each element of the network model. https://doi.org/10.13022/ijahp2017.v9.is1.443
What Constitutes a Novel AHP/ANP Study?
Authors: Mu Enrique 
Published: May 2017

We often receive inquiries about whether a particular study is novel or original enough to be published in our journal. Interestingly enough, whenever a potential author asks this question, the study is likely original enough for publication. Many other potential authors simply submit their studies with the assumption of originality, and they are surprised when they are told their study is not original enough to be published. For this reason, the question of what constitutes a novel study deserves some consideration. https://doi.org/10.13022/ijahp2017.v9.is1.483
Existence occulted: Rhetorical pessimism and the world-without-us
Authors: Zager Brian 
Published: May 2017

Abstract
In his trilogy of books focusing on the interconnections between horror and philosophy, Eugene Thacker continues an ongoing scholarly investigation into the curious relationship between the two aforementioned genres. By submitting that the paradoxical notion of a ‘world-without-us’ haunts both types of cultural projects, Thacker underscores the recurring issues of representation, occulted knowledge and the notion of horror-as-absence in such texts. Drawn to engage this perspective further, I advance that adopting a critical posture of rhetorical pessimism may be helpful to frame the issues of communication at play in both philosophy and horror. To operationalize these ideas, the film Vanishing on 7th Street (Anderson, 2010) is used as a case study.
MODY in Siberia – molecular genetics and clinical characteristics
Authors: Ovsyannikova Alla Konstantinovna , Rymar Oksana Dmitrievna , Shakhtshneider Elena Vladimirovna , Voropaeva Elena Nikolaevna , Ivanoshchuk Dinara Evgenevna , Voevoda Mikhail Ivinovich 
Published: May 2017

The diagnosis of maturity onset diabetes of the young (MODY) has high clinical significance in young patients (no absolute need for exogenous insulin; normoglycaemia in most patients achieved by dieting or taking oral hypoglycaemic agents) and their relatives (high probability of first-degree relatives being carriers of mutations, which requires a thorough collection of family history and determination of the parameters of carbohydrate metabolism).
Aim. This study aimed was to determine the clinical characteristics of different subtypes of MODY in a Siberian region.
Materials and Methods. We performed an examination, biochemical and hormonal blood tests, ultrasound and molecular genetic testing of 20 patients with a clinical diagnosis of MODY.
Results. Four subtypes of MODY were verified: MODY2 in 11 patients, MODY3 in two, MODY8 in one and MODY12 in two. Eleven patients (69%) exhibited no clinical manifestations of carbohydrate metabolism disorders, and one patient showed weight loss during early stage of the disease. Comorbidities included dyslipidemia, thyroid gland disorders and arterial hypertension. One patient (6%) exhibited diabetic nephropathy; two (13%), diabetic retinopathy and three (19%), peripheral neuropathy of lower legs. All patients achieved the target carbohydrate metabolism; the level of C-peptide was within the reference range.
Conclusion. Four different subtypes of MODY (2, 3, 8, 12) were diagnosed in the present study, which differed in their clinical characteristics, presence of complications and treatment strategies. Our knowledge of monogenic forms of diabetes is expanding with the development in molecular genetics, but several aspects related to them require further study.
Hydration enthalpy of amorphous tricalcium phosphate resulting from partially amorphization of β-tricalcium phosphate
Authors: Hurle Katrin , Neubauer Juergen , Goetz-Neunhoeffer Friedlinde 
Published: May 2017

AbstractAs it was recently shown that β-tricalcium phosphate (β-TCP), similar to α-TCP, can be mechanically activated by prolonged ball milling, partially amorphized β-TCP is promising for the development of new bone cement formulations. Hence in the present study the hydration of partially amorphized β-TCP with different contents of an amorphous phase (amorphous tricalcium phosphate, ATCP) was investigated by isothermal calorimetry and quantitative X-ray diffraction (XRD) to obtain the hydration enthalpies of β-TCP and ATCP. Measurements were conducted at 23 °C, a 0.1 M Na
Categorizing English Emotion Formulaic Sequences
Authors: Zhou Rong 
Published: May 2017

Abstract
This paper clarifies the definition of English emotion formulaic sequences in a brand-new way. It identifies the two language processing mechanisms in the human brain that function simultaneously and divide usage depending on the requirements of the language materials and communication situations. Based on the approach of Becker’s hierarchy of classification, this paper categorizes English emotion formulaic sequences from three aspects: structure, meaning, and usage. It may be possible to identify and push the boundaries of English emotion formulaic sequences both for language learners and linguistics researchers.
Anthroposemiotics of Trade Names in the City
Authors: Mosquera Alexander 
Published: May 2017

Abstract
From an anthroposemiotic perspective, this article discusses the presence of trade names written in a language other than Spanish in Venezuela. The notion of identity formulated by García Gavidia and by Andacht is used, as well as notions of violence and symbolic efficacy by Bourdieu and the semiotics of culture by Lotman. An approach was made from the rationalist-deductive epistemological perspective, using the hypothetico-deductive method to analyze a corpus representing foreign trade names observed in Venezuela, which, however, merely served as an empirical control mechanism of deduction. Results reveal that such names are an expression of identity/otherness conflict; at the same time, they can be considered as a cultural text that bursts violently into another established text, by acting within the scope of a semiosphere that transform them into a device with cultural memory expressing an ideological hegemony.
Transformations between Menger systems
Authors: Ricci Gabriele 
Published: May 2017

AbstractTo define transformations between based universal algebras we must introduce representations that depend on the bases, contrary to what was possible for general vector spaces and believed possible for universal algebras. In fact, a counterexample shows that by representation-free transformations alone one cannot even ascertain whether a universal algebra has any dimension or not.A transformation notion, which can do, concerns basis dependent Menger systems. It enjoys a basic geometric property of universal algebras, the preservation of reference flocks, and generalizes the transformation groups of Linear Algebra into groupoids.
Partial semigroups and primality indicators in the fractal generation of binomial coefficients to a prime square modulus
Authors: Doan D. , Kivunge B. , Poole J. J. , Smith J. D. H , Sykes T. , Teplitskiy M. 
Published: May 2017

AbstractThis paper, resulting from two summer programs of Research Experience for Undergraduates, examines the congruence classes of binomial coefficients to a prime square modulus as given by a fractal generation process for lattice path counts. The process depends on the isomorphism of partial semigroup structures associated with each iteration. We also consider integrality properties of certain critical coefficients that arise in the generation process. Generalizing the application of these coefficients to arbitrary arguments, instead of just to the prime arguments appearing in their original function, it transpires that integrality of the coefficients is indicative of the primality of the argument.
Sums of products of generalized Fibonacci and Lucas numbers
Authors: Čerin Zvonko 
Published: May 2017

AbstractIn this paper we obtain explicit formulae for sums of products of a fixed number of consecutive generalized Fibonacci and Lucas numbers. These formulae are related to the recent work of Belbachir and Bencherif. We eliminate all restrictions about the initial values and the form of the recurrence relation. In fact, we consider six different groups of three sums that include alternating sums and sums in which terms are multiplied by binomial coefficients and by natural numbers. The proofs are direct and use the formula for the sum of the geometric series.
A quadratic transformation of the three-dimensional space of all conics through two points of a projective plane
Authors: Donati Giorgio 
Published: May 2017

AbstractUsing the Steiner’s method of projective generation of conics and its dual we define two projective mappings of a double contact pencil of conics into itself and we prove that one is the inverse of the other. We show that these projective mappings are induced by quadratic transformations of the three-dimensional projective space of all conics through two distinct points of a projective plane.
On some operations on finite affine planes applied to the theory of regular configurations
Authors: Makowiecka Hanna 
Published: May 2017

AbstractWe consider some operations on affine planes which resemble the construction of a derived affine plane at a point of the Benz plane. We call them Benz-contractions (B-contractions), distinguishing between chain contractions and generator contractions. We prove that the Pappos–Pascal configuration is the B-contraction of the affine plane of order 4 and we relate it to the Havliček–Tietze configuration. We present a new (HT)
On homotopy classification of phrases and its application
Authors: Fukunaga Tomonori 
Published: May 2017

AbstractThis paper is a survey on the recent study of homotopy theory of generalized phrases in Turaev’s theory of words and phrases. In this paper, we introduce the homotopy classification of generalized phrases with some conditions on numbers of letters. The theory of topology of words and phrases are closely related to the theory of surface-curves. We also introduce applications of topology of words to the topology of surface-curves.