bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrological Impact of Remotely Sensed Interannual Vegetation Variability in the Upper Colorado River Basin
Authors: Longyang Qianqiu , Zeng Ruijie 
Published: September 2024

AbstractVegetation plays a crucial role in atmosphere‐land water and energy exchanges, global carbon cycle and basin water conservation. Land Surface Models (LSMs) typically represent vegetation characteristics by monthly climatological indices. However, static vegetation parameterization does not fully capture time‐varying vegetation characteristics, such as responses to climatic fluctuations, long‐term trends, and interannual variability. It remains unclear how the interaction between vegetation and climate variability propagates into hydrologic fluxes and water resources. Multi‐source satellite data sets may introduce uncertainties and require extensive time for analysis. This study developes a deep learning surrogate for a widely used LSM (i.e., Noah) as a rapid diagnosic tool. The calibrated surrogate quantifies the impacts of time‐varying vegetation characteristics from multiple remotely sensed GVF products on the magnitude, seasonality, and biotic and abiotic components of hydrologic fluxes. Using the Upper Colorado River Basin (UCRB) as a test case, we found that time‐varying vegetation provides more buffering effect against climate fluctuation than the static vegetation configuration, leading to reduced variability in the abiotic evaporation components (e.g., soil evaporation). In addition, time‐varying vegetation from multi‐source remote sensing products consistently predicts smaller biotic evaporation components (e.g., transpiration), leading to increased water yield in the UCRB (about 14%) compared to the static vegetation scheme. We also highlight the interaction between dynamic vegetation parameterization and static parameterization (e.g., soil) during calibration. Parameter recalibration and a re‐evaluation of certain model assumptions may be required for assessing climate change impacts on vegetation and basin‐wide water resources.
Deep‐Learning Phase‐Onset Picker for Deep Earth Seismology: PKIKP Waves
Authors: Zhou Jiarun , Phạm Thanh‐Son , Tkalčić Hrvoje 
Published: September 2024

AbstractBody waves traversing the Earth's interior from a seismic source to receivers on the surface carry rich information about its internal structures. Their travel time measurements have been widely used in seismology to constrain Earth's interior at the global scale by mapping the time anomaly along their ray paths. However, picking the travel time of global seismic waves, suitable for studying Earth's fine‐scale structures, requires highly skilled personnel and is often fairly subjective. Here, we report the development of an automatic picker for PKIKP waves traveling through the inner core (IC), especially nearly along Earth's diameters, based on the latest advances in supervised deep learning. A convolutional neural network (CNN) we develop automatically determines the PKIKP onset on vertical seismograms near its theoretical prediction of cataloged earthquakes. As high‐quality manual onset picks of global seismic phases are limited, we employ a scheme to generate a synthetic supervised training data set containing 300,000 waveforms. The PKIKP onsets picked by our trained CNN automatic picker exhibit a mean absolute error of ∼0.5 s compared to 1,503 manual picks, comparable to the estimated human‐picking error. In an integration test, the automatic picks obtained from an extended waveform data set yield a cylindrically anisotropic IC model that agrees well with the models inferred from manual picks, which illustrates the success of this pilot model. This is a significant step closer to harvesting an unprecedented volume of travel time measurements for studying the IC or other regions of the Earth's deep interior.
Contribution of Western Arabian Sea Tropical Cyclones to Rainfall in the Horn of Africa and Southern Arabian Peninsula
Authors: Camberlin P. , Assowe Dabar O. , Pohl B. , Mohamed Waberi M. , Hoarau K. , Planchon O. 
Published: September 2024

AbstractThe occurrence of tropical cyclones (TCs) in the Horn of Africa and nearby areas is for the first time examined to document their contribution to local rainfall and their trends over the period 1990–2020. An average 1.5 TC (of any intensity) per year was observed over the Western Arabian Sea, with two asymmetrical seasons, namely May–June (30% of cyclonic days) and September–December (70%). Case studies reveal that in many instances, TC‐related rainfall extends beyond 500 km from the TC center, and that substantial rains occur one to 2 days after the lifecycle of the TC. Despite their rarity, in the otherwise arid to semi‐arid context characteristic of the region, TCs contribute in both seasons to a very high percentage of total rainfall (up to 30%–60%) over the northwestern Arabian Sea, the Gulf of Aden and their coastlines. Over inland northern Somalia, contributions are much lower. TCs disproportionately contribute to some of the most intense daily falls, which are often higher than the mean annual rainfall. A strong increase in the number of TCs is found from 1990 to 2020, hence their enhanced contribution to local rainfall. This increase is associated with a warmer eastern/southern Arabian Sea, a decrease in vertical wind shear, and a strong increase in tropospheric moisture content.
Role of Clouds in the Urban Heat Island and Extreme Heat: Houston‐Galveston Metropolitan Area Case
Authors: Mejia John F. , Henao Juan Jose , Eslami Ebrahim 
Published: September 2024

AbstractThis study examines the influence of shallow cumulus clouds on the excessive summertime heat in the Houston‐Galveston metropolitan area, a coastal urban area in the warm Southeast United States. Specifically, it aims to improve our understanding of how both the clouds and the relatively cool, moist afternoon sea breeze impact the Urban Heat Island (UHI) and Heat Index (HI). During the warm season, the afternoon sea breeze phenomenon in this coastal city acts as a natural air conditioner for city residents, facilitating the dispersion of moisture, heat, and pollutants. To investigate the relationship among urbanization, clouds, and land‐sea interactions, we conducted cloud‐ and urban‐resolving simulations at a 900 m grid resolution and perform simulation scenarios aiming to isolate urbanization, clouds and land‐sea circulations. Results show that urbanization correlates with the presence of shallow cumulus clouds, higher cloud bases, and increased cloud duration over the Galveston‐Houston region compared to rural areas. These urban clouds benefit from the enhanced moist static energy that is favored by intensifying vertical mixing and moisture flux convergence. Urbanization raises the mean HI while mitigating its afternoon HI high. We found that the urban circulation dome overwhelms the sensitivity of the sea breeze to the urbanization. Instead, the influence of urbanization on cloud enhancement emerges as a crucial pathway responsible for reducing the high afternoon HI values. Moreover, uncertainties in SSTs are closely linked to the sensitivities of land‐sea circulations, which in turn modulate UHI and HI.
Lens-free on-chip 3D microscopy based on wavelength-scanning Fourier ptychographic diffraction tomography
Authors: Wu Xuejuan , Zhou Ning , Chen Yang , Sun Jiasong , Lu Linpeng , Chen Qian , Zuo Chao 
Published: September 2024

AbstractLens-free on-chip microscopy is a powerful and promising high-throughput computational microscopy technique due to its unique advantage of creating high-resolution images across the full field-of-view (FOV) of the imaging sensor. Nevertheless, most current lens-free microscopy methods have been designed for imaging only two-dimensional thin samples. Lens-free on-chip tomography (LFOCT) with a uniform resolution across the entire FOV and at a subpixel level remains a critical challenge. In this paper, we demonstrated a new LFOCT technique and associated imaging platform based on wavelength scanning Fourier ptychographic diffraction tomography (wsFPDT). Instead of using angularly-variable illuminations, in wsFPDT, the sample is illuminated by on-axis wavelength-variable illuminations, ranging from 430 to 1200 nm. The corresponding under-sampled diffraction patterns are recorded, and then an iterative ptychographic reconstruction procedure is applied to fill the spectrum of the three-dimensional (3D) scattering potential to recover the sample’s 3D refractive index (RI) distribution. The wavelength-scanning scheme not only eliminates the need for mechanical motion during image acquisition and precise registration of the raw images but secures a quasi-uniform, pixel-super-resolved imaging resolution across the entire imaging FOV. With wsFPDT, we demonstrate the high-throughput, billion-voxel 3D tomographic imaging results with a half-pitch lateral resolution of 775 nm and an axial resolution of 5.43 μm across a large FOV of 29.85 mm2 and an imaging depth of >200 μm. The effectiveness of the proposed method was demonstrated by imaging various types of samples, including micro-polystyrene beads, diatoms, and mouse mononuclear macrophage cells. The unique capability to reveal quantitative morphological properties, such as area, volume, and sphericity index of single cell over large cell populations makes wsFPDT a powerful quantitative and label-free tool for high-throughput biological applications.
Active surveillance selection and 3-year durability in intermediate-risk prostate cancer following genomic testing
Authors: Lenz Lauren , Clegg Wyatt , Iliev Diana , Kasten Chelsea R. , Korman Howard , Morgan Todd M. , Hafron Jason , DeHaan Alexander , Olsson Carl , Tutrone Ronald F. , Richardson Timothy , Cline Kevin , Yonover Paul M. , Jasper Jeff , Cohen Todd , Finch Robert , Slavin Thomas P. , Gutin Alexander 
Published: September 2024

Abstract
Background
Genomic testing can add risk stratification information to clinicopathological features in prostate cancer, aiding in shared medical decision-making between the clinician and patient regarding whether active surveillance (AS) or definitive treatment (DT) is most appropriate. Here we examined initial AS selection and 3-year AS durability in patients diagnosed with localized intermediate-risk prostate cancer who underwent Prolaris testing before treatment decision-making.

Methods
This retrospective observational cohort study included 3208 patients from 10 study sites who underwent Prolaris testing at diagnosis from September 2015 to December 2018. Prolaris utilizes a combined clinical cell cycle risk score calculated at diagnostic biopsy to stratify patients by the Prolaris AS threshold (below threshold, patient recommended to AS or above threshold, patient recommended to DT). AS selection rates and 3-year AS durability were compared in patients recommended to AS or DT by Prolaris testing. Univariable and multivariable logistic regression models and Cox proportional hazard models were used with molecular and clinical variables as predictors of initial treatment decision and AS durability, respectively.

Results
AS selection was ~2 times higher in patients recommended to AS by Prolaris testing than in those recommended to DT (p < 0.0001). Three-year AS durability was ~1.5 times higher in patients recommended to AS by Prolaris testing than in those recommended to DT (p < 0.0001). Prolaris treatment recommendation remained a statistically significant predictor of initial AS selection and AS durability after accounting for CAPRA or Gleason scores.

Conclusions
Prolaris added significant information to clinical risk stratification to aid in treatment decision making. Intermediate-risk prostate cancer patients who were recommended to AS by Prolaris were more likely to initially pursue AS and were more likely to remain on AS at 3 years post-diagnosis than patients recommended to DT.
Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects
Authors: Yao Zhenqiang , Ayoub Akram , Srinivasan Venkatesan , Wu Jun , Tang Churou , Duan Rong , Milosavljevic Aleksa , Xing Lianping , Ebetino Frank H. , Frontier Alison J. , Boyce Brendan F. 
Published: September 2024

AbstractOsteoporosis remains incurable. The most widely used antiresorptive agents, bisphosphonates (BPs), also inhibit bone formation, while the anabolic agent, teriparatide, does not inhibit bone resorption, and thus they have limited efficacy in preventing osteoporotic fractures and cause some side effects. Thus, there is an unmet need to develop dual antiresorptive and anabolic agents to prevent and treat osteoporosis. Hydroxychloroquine (HCQ), which is used to treat rheumatoid arthritis, prevents the lysosomal degradation of TNF receptor-associated factor 3 (TRAF3), an NF-κB adaptor protein that limits bone resorption and maintains bone formation. We attempted to covalently link HCQ to a hydroxyalklyl BP (HABP) with anticipated low antiresorptive activity, to target delivery of HCQ to bone to test if this targeting increases its efficacy to prevent TRAF3 degradation in the bone microenvironment and thus reduce bone resorption and increase bone formation, while reducing its systemic side effects. Unexpectedly, HABP-HCQ was found to exist as a salt in aqueous solution, composed of a protonated HCQ cation and a deprotonated HABP anion. Nevertheless, it inhibited osteoclastogenesis, stimulated osteoblast differentiation, and increased TRAF3 protein levels in vitro. HABP-HCQ significantly inhibited both osteoclast formation and bone marrow fibrosis in mice given multiple daily PTH injections. In contrast, HCQ inhibited marrow fibrosis, but not osteoclast formation, while the HABP alone inhibited osteoclast formation, but not fibrosis, in the mice. HABP-HCQ, but not HCQ, prevented trabecular bone loss following ovariectomy in mice and, importantly, increased bone volume in ovariectomized mice with established bone loss because HABP-HCQ increased bone formation and decreased bone resorption parameters simultaneously. In contrast, HCQ increased bone formation, but did not decrease bone resorption parameters, while HABP also restored the bone lost in ovariectomized mice, but it inhibited parameters of both bone resorption and formation. Our findings suggest that the combination of HABP and HCQ could have dual antiresorptive and anabolic effects to prevent and treat osteoporosis.
A bitopic agonist bound to the dopamine 3 receptor reveals a selectivity site
Authors: Arroyo-Urea Sandra , Nazarova Antonina L. , Carrión-Antolí Ángela , Bonifazi Alessandro , Battiti Francisco O. , Lam Jordy Homing , Newman Amy Hauck , Katritch Vsevolod , García-Nafría Javier 
Published: September 2024

AbstractAlthough aminergic GPCRs are the target for ~25% of approved drugs, developing subtype selective drugs is a major challenge due to the high sequence conservation at their orthosteric binding site. Bitopic ligands are covalently joined orthosteric and allosteric pharmacophores with the potential to boost receptor selectivity and improve current medications by reducing off-target side effects. However, the lack of structural information on their binding mode impedes rational design. Here we determine the cryo-EM structure of the hD3R:GαOβγ complex bound to the D3R selective bitopic agonist FOB02-04A. Structural, functional and computational analyses provide insights into its binding mode and point to a new TM2-ECL1-TM1 region, which requires the N-terminal ordering of TM1, as a major determinant of subtype selectivity in aminergic GPCRs. This region is underexploited in drug development, expands the established secondary binding pocket in aminergic GPCRs and could potentially be used to design novel and subtype selective drugs.
Tbps wide-field parallel optical wireless communications based on a metasurface beam splitter
Authors: Wu Yue , Chen Ji , Wang Yin , Yuan Zhongyi , Huang Chunyu , Sun Jiacheng , Feng Chengyi , Li Muyang , Qiu Kai , Zhu Shining , Zhang Zaichen , Li Tao 
Published: September 2024

AbstractOptical wireless communication (OWC) stands out as one of the most promising technologies in the sixth-generation (6G) mobile networks. The establishment of high-quality optical links between transmitters and receivers plays a crucial role in OWC performances. Here, by a compact beam splitter composed of a metasurface and a fiber array, we proposed a wide-angle (~120°) OWC optical link scheme that can parallelly support up to 144 communication users. Utilizing high-speed optical module sources and wavelength division multiplexing technique, we demonstrated each user can achieve a communication speed of 200 Gbps which enables the entire system to support ultra-high communication capacity exceeding 28 Tbps. Furthermore, utilizing the metasurface polarization multiplexing, we implemented a full range wide-angle OWC without blind area nor crosstalk among users. Our OWC scheme simultaneously possesses the advantages of high-speed, wide communication area and multi-user parallel communications, paving the way for revolutionary high-performance OWC in the future.
Electrically tunable infrared optics enabled by flexible ion-permeable conducting polymer-cellulose paper
Authors: Kuang Chaoyang , Chen Shangzhi , Liao Mingna , Rahmanudin Aiman , Banerjee Debashree , Edberg Jesper , Tybrandt Klas , Zhao Dan , Jonsson Magnus P. 
Published: September 2024

AbstractMaterials that provide dynamically tunable infrared (IR) response are important for many applications, including active camouflage and thermal management. However, current IR-tunable systems often exhibit limitations in mechanical properties or practicality of their tuning modalities, or require complex and costly fabrication methods. An additional challenge relates to providing compatibility between different spectral channels, such as allowing an object to be reversibly concealed in the IR without making it appear in the visible range. Here, we demonstrate that conducting polymer-cellulose papers, fabricated through a simple and cheap approach, can overcome such challenges. The papers exhibit IR properties that can be electrochemically tuned with large modulation (absolute emissivity modulation of 0.4) while maintaining largely constant response in the visible range. Owing to high ionic and electrical conductivity, the tuning of the top surface can be performed electrochemically from the other side of the paper even at tens of micrometer thicknesses, removing the need for overlaying electrode and electrolyte in the optical beam path. These features enabled a series of electrically tunable IR devices, where we focus on demonstrating dynamic radiative coolers, thermal camouflage, anti-counterfeiting tags, and grayscale IR displays. The conducting polymer-cellulose papers are sustainable, cheap, flexible and mechanically robust, providing a versatile materials platform for active and adaptive IR optoelectronic devices.
Bio-spectroscopic investigation linking changes of retinal structure with short-term administration of Amiodarone and revealing the ameliorative effect of vitamin E supplementation
Authors: Mahmoud Sherif S. , Morsy Sahar A. , Aly Eman M. , Mohalhal Islam A. 
Published: September 2024

AbstractLong term use of Amiodarone (AMIO) is associated with the development of ocular adverse effects. This study investigates the short term effects, and the ameliorative consequence of vitamin E on retinal changes that were associated with administration of AMIO. This is accomplished by investigating both retinal structural and conformational characteristics using Fourier transform infrared spectroscopy (FTIR) and Fundus examination. Three groups of healthy rabbits of both sexes were used; the first group served as control. The second group was orally treated with AMIO (160 mg /kg body weight) in a daily basis for two weeks. The last group orally received AMIO as the second group for two weeks then, oral administration of vitamin E (100 mg/kg body weight) for another two weeks as well. FTIR results revealed significant structural and conformational changes in retinal tissue constituents that include lipids and proteins due to AMIO administration. AMIO treatment was associated with fluctuated changes (increased/decreased) in the band position and bandwidth of NH, OH, and CH bonds. This was concomitant with changes in the percentage of retinal protein constituents in particularly α-helix and Turns. AMIO facilitates the formation of intra-molecular hydrogen bonding and turned retinal lipids to be more disordered structure. In conclusion, the obtained FTIR data together with principal component analysis provide evidence that administration of vitamin E following the treatment with AMIO can ameliorate these retinal changes and, these biophysical changes are too early to be detected by Fundus examination.
A new method called MiKneeSoTA to minimize knee soft-tissue artifacts in kinematic analysis
Authors: Einfeldt Ann-Kathrin , Budde Leon , Ortigas-Vásquez Ariana , Sauer Adrian , Utz Michael , Jakubowitz Eike 
Published: September 2024

AbstractThe use of marker-based optical motion capture to estimate joint kinematics during gait is currently limited by errors associated with soft-tissue-induced motion artefacts (STIMA) and ambiguity in landmark palpation. This study therefore presents a novel protocol aiming to Minimize Knee Soft-Tissue Artefacts (MiKneeSoTA) and their effect on kinematic estimates. Relying on an augmented marker set and a new inverse kinematics approach, our method leverages frame-by-frame optimization to adjust best-fit cylinders that have been automatically generated based on the relative position of lower limb markers during an initial static trial. Tibiofemoral rotations and translations are then calculated along the anatomical joint axes based on the relative 3D motion of these cylinders. When compared against the conventional Helen-Hayes approach, in vivo assessment of fifteen healthy subjects revealed the MiKneeSoTA approach led to kinematic profiles with significantly lower standard deviations in joint rotations across trials, and even visibly reduced the presence of high frequency fluctuations presumably associated with e.g. soft-tissue vibration. In addition to agreeing with previously published bone pin and fluoroscopy datasets, our results illustrate MiKneeSoTA’s ability to abate the effect of STIMA induced by lateral knee ligaments. Our findings indicate that MiKneeSoTA is in fact a promising approach to mitigate knee joint STIMA and thus enable the previously unattainable accurate estimation of translational knee joint motion with an optoelectronic system.