bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shock-wave processing of C60 in hydrogen
Authors: Biennier L. , Jayaram V. , Suas-David N. , Georges R. , Singh M. Kiran , Arunan E. , Kassi S. , Dartois E. , Reddy K. P. J. 
Published: November 2016

Context. Interstellar carbonaceous particles and molecules are subject to intense shocks in astrophysical environments. Shocks induce a rapid raise in temperature and density which strongly affects the chemical and physical properties of both the gas and solid phases of the interstellar matter.
Aims. The shock-induced thermal processing of C60 particles in hydrogen has been investigated in the laboratory under controlled conditions up to 3900 K with the help of a material shock-tube.
Methods. The solid residues generated by the exposure of a C60/H2 mixture to a millisecond shock wave were collected and analyzed using X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Raman micro-spectroscopy, and infrared micro-spectroscopy. The gaseous products were analyzed by Gas Chromatography and Cavity Ring Down Spectroscopy.
Results. Volatile end-products appear above reflected shock gas temperatures of ~2540 K and reveal the substantial presence of small molecules with one or two C atoms. These observations confirm the role played by the C2 radical as a major product of C60 fragmentation and less expectedly highlight the existence of a single C atom loss channel. Molecules with more than two carbon atoms are not observed in the post-shock gas. The analysis of the solid component shows that C60 particles are rapidly converted into amorphous carbon with a number of aliphatic bridges.
Conclusions. The absence of aromatic CH stretches on the IR spectra indicates that H atoms do not link directly to aromatic cycles. The fast thermal processing of C60 in H2 over the 800–3400 K temperature range leads to amorphous carbon. The analysis hints at a collapse of the cage with the formation of a few aliphatic connections. A low amount of hydrogen is incorporated into the carbon material. This work extends the range of applications of shock tubes to studies of astrophysical interest.
A prospective examination of the impact of high levels of exercise training on sedentary behaviour
Authors: Swartz Ann M. , Miller Nora E. , Cho Young IK , Welch Whitney A. , Strath Scott J. 
Published: November 2016

AbstractThe aim of this study is to determine changes in sedentary behaviour in response to extensive aerobic exercise training. Participants included adults who self‐selected to run a marathon. Sedentary behaviour, total activity counts and physical activity (PA) intensity were assessed (Actigraph GT3X) for seven consecutive days during seven assessment periods (−3, −2, and −1 month prior to the marathon, within 2 weeks of the marathon, and +1, +2, and +3 months after the marathon). Models were fitted with multiple imputation data using the STATA mi module. Random intercept generalized least squares (GLS) regression models were used to determine change in sedentary behaviour with seven waves of repeated measures. Results: Twenty‐three individuals (mean ± Sx: 34.4 ± 2.1y, 23.0 ± 1.9% fat, 15 women, 8 men) completed the study. Marathon finishing times ranged from 185 to 344 minutes (253.2 ± 9.6 minutes). Total counts in the vertical axis were 1,729,414 lower one month after the race, compared with two months prior to the race (peak training). Furthermore, counts per minute decreased by 252.7 counts·minute−1 during that same time period. Daily sedentary behaviour did not change over the seven assessment periods, after accounting for age, gender, per cent body fat, wear time, marathon finishing time, and previous marathon experience. This prospective study supports the notion that PA and sedentary behaviours are distinct, showing that sedentary behaviour was not impacted by high levels of aerobic training.
Crime reporting as storytelling in Persian/Farsi news journalism – perspectives on the narrative function
Authors: White P.R.R. , Makki Mohammad 
Published: November 2016

Abstract
This paper is concerned with the nature of storytelling and how different types of story or narrative might be classified and characterised by reference to their generic structures and ultimate social functions. More specifically, it is concerned with Persian/Farsi-language reports of crimes in Iranian newspapers. It describes and analyses the various ways in which these texts are organised structurally, informationally and with respect to “newsworthiness”, the various ways in which they deal with chronological sequence and the various ways in which they position the reader attitudinally vis-à-vis the events described and/or their protagonists. In so doing, it provides insights into the similarities and differences between these instances of Persian/Farsi journalism and what the journalism studies literature has presented as “typical” of modern news reports in English and other languages. It also provides insights into the nature of these Iranian crime reports as instances of storytelling or narrative, proposing that taxonomies of the different subtypes of storytelling outlined in the Sydney Genre School literature should be refined to accommodate the modes of storytelling observed in the authors’ data set of crime reports.
SPADEVizR: an R package for visualization, analysis and integration of SPADE results
Authors: Gautreau Guillaume , Pejoski David , Le Grand Roger , Cosma Antonio , Beignon Anne-Sophie , Tchitchek Nicolas 
Published: November 2016

Abstract

Motivation
Flow, hyperspectral and mass cytometry are experimental techniques measuring cell marker expressions at the single cell level. The recent increase of the number of markers simultaneously measurable has led to the development of new automatic gating algorithms. Especially, the SPADE algorithm has been proposed as a novel way to identify clusters of cells having similar phenotypes in high-dimensional cytometry data. While SPADE or other cell clustering algorithms are powerful approaches, complementary analysis features are needed to better characterize the identified cell clusters.

Results
We have developed SPADEVizR, an R package designed for the visualization, analysis and integration of cell clustering results. The available statistical methods allow highlighting cell clusters with relevant biological behaviors or integrating them with additional biological variables. Moreover, several visualization methods are available to better characterize the cell clusters, such as volcano plots, streamgraphs, parallel coordinates, heatmaps, or distograms. SPADEVizR can also generate linear, Cox or random forest models to predict biological outcomes, based on the cell cluster abundances. Additionally, SPADEVizR has several features allowing to quantify and to visualize the quality of the cell clustering results. These analysis features are essential to better interpret the behaviors and phenotypes of the identiﬁed cell clusters. Importantly, SPADEVizR can handle clustering results from other algorithms than SPADE.

Availability and Implementation
SPADEVizR is distributed under the GPL-3 license and is available at https://github.com/tchitchek-lab/SPADEVizR.

Supplementary information
Supplementary data are available at Bioinformatics online.
A flat-spectrum candidate for a track-type high-energy neutrino emission event, the case of blazar PKS 0723−008
Authors: Kun E. , Biermann P. L. , Gergely L. Á. 
Published: November 2016

Abstract
By cross-correlating both the Parkes Catalogue and the Second Planck Catalogue of Compact Sources with the arrival direction of the track-type neutrinos detected by the IceCube Neutrino Observatory, we find the flat-spectrum blazar PKS 0723−008 as a good candidate for the high-energy neutrino event 5 (ID5). Apart from its coordinates matching those of ID5, PKS 0723−008 exhibits further interesting radio properties. Its spectrum is flat up to high Planck frequencies, and it produced a fivefold-increased radio flux density through the last decade. Based upon these radio properties we propose a scenario of binary black hole evolution leading to the observed high-energy neutrino emission. The main contributing events are the spin-flip of the dominant black hole, the formation of a new jet with significant particle acceleration and interaction with the surrounding material, with the corresponding increased radio flux. Doppler boosting from the underlying jet pointing to the Earth makes it possible to identify the origin of the neutrinos, so the merger itself is the form of an extended flat-spectrum radio emission, a key selection criterion to find traces of this complex process.
Do Positive Anaerobic Culture Results Affect Physicians’ Clinical Management Decisions?
Authors: Bhowmick Tanaya , Varughese Tilly A. , Arakali Schweta , Boruchoff Susan E. 
Published: November 2016

Abstract

Background
Aerobic and anaerobic cultures from body fluids, abscesses, and wounds are ordered routinely. Prior studies have shown that the results of anaerobic blood cultures do not frequently lead to changes in patient management.

Methods
We performed a retrospective chart review to determine whether positive results of anaerobic tissue and fluid cultures (excluding blood) affect physicians’ treatment approaches. Of 3234 anaerobic cultures, 174 unique patient admissions had positive cultures and met inclusion criteria.

Results
Only 18% (n = 31) of patient charts with positive cultures had documented physician acknowledgment (90.3% of acknowledgments by infectious diseases physicians), with 9% (n = 15) leading to change in antibiotic regimens based on results. Seventy percent of all patients received initial empiric antibiotics active against anaerobes. Of the remaining 30% (inappropriate, unknown, or no empiric coverage), 1 regimen change was documented after culture results were known.

Conclusions
Given the lack of management change based on results of anaerobic wound cultures, the value of routine anaerobic culturing is of questionable utility.
Naïveté-Based Discrimination*
Authors: Heidhues Paul , Kőszegi Botond 
Published: November 2016

Abstract
We initiate the study of naïveté-based discrimination, the practice of conditioning offers on external information about consumers’ naïveté. Knowing that a consumer is naive increases a monopolistic or competitive firm's willingness to generate inefficiency to exploit the consumer's mistakes, so naïveté-based discrimination is not Pareto-improving, can be Pareto-damaging, and often lowers total welfare when classical preference-based discrimination does not. Moreover, the effect on total welfare depends on a hitherto unemphasized market feature: the extent to which the exploitation of naive consumers distorts trade with different types of consumers. If the distortion is homogeneous across naive and sophisticated consumers, then under an arguably weak and empirically testable condition, naïveté-based discrimination lowers total welfare. In contrast, if the distortion arises only for trades with sophisticated consumers, then perfect naïveté-based discrimination maximizes social welfare, although imperfect discrimination often lowers welfare. If the distortion arises only for trades with naive consumers, then naïveté-based discrimination has no effect on welfare. We identify applications for each of these cases. In our primary example, a credit market with present-biased borrowers, firms lend more than is socially optimal to increase the amount of interest naive borrowers unexpectedly pay, creating a homogeneous distortion. The condition for naïveté-based discrimination to lower welfare is then weaker than prudence.
Epidemiological Differences Between Localized and Nonlocalized Low Back Pain
Authors: Coggon David , Ntani Georgia , Walker-Bone Karen , Palmer Keith T. , Felli Vanda E. , Harari Raul , Barrero Lope H. , Felknor Sarah A. , Gimeno David , Cattrell Anna , Vargas-Prada Sergio , Bonzini Matteo , Solidaki Eleni , Merisalu Eda , Habib Rima R. , Sadeghian Farideh , Kadir M. Masood , Warnakulasuriya Sudath SP , Matsudaira Ko , Nyantumbu Busisiwe , Sim Malcolm R. , Harcombe Helen , Cox Ken , Sarquis Leila M.M. , Marziale Maria H. , Harari Florencia , Freire Rocio , Harari Natalia , Monroy Magda V. , Quintana Leonardo A. , Rojas Marianela , Harris Elizabeth Clare , Serra Consol , Martinez José Miguel , Delclos George , Benavides Fernando G. , Carugno Michele , Ferrario Marco M. , Pesatori Angela C. , Chatzi Leda , Bitsios Panos , Kogevinas Manolis , Oha Kristel , Freimann Tiina , Sadeghian Ali , Peiris-John Roshini J. , Sathiakumar Nalini , Wickremasinghe A. Rajitha , Yoshimura Noriko , Kelsall Helen L. , Hoe Victor C.W. , Urquhart Donna M. , Derrett Sarah , McBride David , Herbison Peter , Gray Andrew , Salazar Vega Eduardo J. 
Published: November 2016

Study Design.
A cross-sectional survey with a longitudinal follow-up.

Objectives.
The aim of this study was to test the hypothesis that pain, which is localized to the low back, differs epidemiologically from that which occurs simultaneously or close in time to pain at other anatomical sites

Summary of Background Data.
Low back pain (LBP) often occurs in combination with other regional pain, with which it shares similar psychological and psychosocial risk factors. However, few previous epidemiological studies of LBP have distinguished pain that is confined to the low back from that which occurs as part of a wider distribution of pain.

Methods.
We analyzed data from CUPID, a cohort study that used baseline and follow-up questionnaires to collect information about musculoskeletal pain, associated disability, and potential risk factors, in 47 occupational groups (office workers, nurses, and others) from 18 countries.

Results.
Among 12,197 subjects at baseline, 609 (4.9%) reported localized LBP in the past month, and 3820 (31.3%) nonlocalized LBP. Nonlocalized LBP was more frequently associated with sciatica in the past month (48.1% vs. 30.0% of cases), occurred on more days in the past month and past year, was more often disabling for everyday activities (64.1% vs. 47.3% of cases), and had more frequently led to medical consultation and sickness absence from work. It was also more often persistent when participants were followed up after a mean of 14 months (65.6% vs. 54.1% of cases). In adjusted Poisson regression analyses, nonlocalized LBP was differentially associated with risk factors, particularly female sex, older age, and somatizing tendency. There were also marked differences in the relative prevalence of localized and nonlocalized LBP by occupational group.

Conclusion.
Future epidemiological studies should distinguish where possible between pain that is limited to the low back and LBP that occurs in association with pain at other anatomical locations.

Level of Evidence: 2
Prognostic Factors, Treatment, and Outcomes in Early Stage, Invasive Papillary Breast Cancer
Authors: Fakhreddine Mohamad H. , Haque Waqar , Ahmed Awad , Schwartz Mary R. , Farach Andrew M. , Paulino Arnold C. , Bonefas Elizabeth , Miltenburg Darlene , Niravath Polly , Butler E. Brian , Teh Bin S. 
Published: November 2016

Objectives:
Invasive papillary breast cancer (IPBCA) represents 0.5% of invasive BCA, and is thought to carry a favorable prognosis. This population-based study reports on prognostic factors, treatment, and outcomes of early-stage IPBCA to explore whether there is any evidence to support less aggressive treatment.

Materials and Methods:
IPBCA cases from 1990 to 2009 of the recent Surveillance, Epidemiology, and End Results were analyzed. Inclusion criteria included patients with stage T1-2, N0 IPBCA. Univariate and multivariate analyses were performed using the variables of treatment, stage, race, hormone receptor status, grade (G1-3), and age. Treatment modalities included lumpectomy alone (LA), lumpectomy with radiation treatment (LRT), and mastectomy alone (MA).

Results:
Among 10,485 patients, median follow-up was 56 months. Five and 10-year overall survival (OS) were 93.1% and 76.8%, respectively. Patients treated with LRT had superior mean OS 16.8 versus 14.9 years for MA (P=0.0004) and 14.2 years for LA (P=0.0003). Improved OS also correlated with lower histologic grade (P<0.0001), lower T-stage (P<0.0001), and younger age (P<0.0001). Black patients had the worst OS (12.7 y, P<0.0001).

Conclusions:
LRT is associated with superior OS for early-stage invasive papillary BCA patients, when compared with LA or MA in this population-based study. The findings support the standard of care breast conservation approach for patients with invasive papillary BCA. Other prognostic factors associated with worse OS include increased age, higher T-stage, higher histologic grade, and black race.
Impact of Postoperative Adjuvant Chemotherapy Following Long-course Chemoradiotherapy in Stage II Rectal Cancer
Authors: Loree Jonathan M. , Kennecke Hagen F. , Lee-Ying Richard M. , Goodwin Rachel A. , Powell Erin D. , Tang Patricia A. , Price Hiller Julie A. , Vickers Michael M. , Cheung Winson Y. 
Published: November 2016

Objectives:
Use of adjuvant chemotherapy (AC) following neoadjuvant chemoradiation (nCRT) is controversial in rectal cancer (RC). We assessed a multi-institutional database to determine if there was benefit from AC for pathologic stage II RC patients and whether the addition of oxaliplatin to fluoropyrimidine (OXAC) therapy impacted outcomes.

Materials and Methods:
We included patients who underwent nCRT and had pathologic stage II (ypT3/4 ypN0) tumors. Disease-free survival and overall survival were assessed. Multivariate Cox models adjusting for age, sex, Eastern Cooperative Oncology Group, high-risk features (pT4, poor differentiation, <12 nodes removed, lymphovascular/perineural invasion, or obstruction/perforation), and clinical stage were constructed.

Results:
Of 485 patients, 73.6% received AC, of which 25.5% received OXAC. Patients receiving AC were younger (median age 61 vs. 64; P=0.003) and had higher rates of total mesorectal excision (81.5% vs. 78.9%; P=0.049), but had similar high-risk features, performance status, clinical stage, margin status, preoperative carcinoembryonic antigen, and nCRT regimen. In univariate analysis, overall survival was improved with fluoropyrimidine AC compared with no AC or OXAC (P=0.049), but not disease-free survival (P=0.33). In multivariate analysis, any AC, fluoropyrimidine AC, or OXAC did not improve outcomes. After stratifying patients by the presence of high-risk features, elevated carcinoembryonic antigen, margin status, or preoperative clinical stage, we did not identify a group with improved outcomes following AC.

Conclusions:
In this multi-institutional cohort of yp stage II RC patients, we failed to identify a group that derives benefit from AC following nCRT. The addition of oxaliplatin did not appear to improve outcomes when compared with fluoropyrimidine alone.
Clinical Outcomes After Lung Stereotactic Body Radiation Therapy in Patients With or Without a Prior Lung Resection
Authors: Hou Ying , Hermann Gretchen , Lewis John H. , Aerts Hugo J. , Baldini Elizabeth H. , Chen Aileen B. , Colson Yolonda L. , Hacker Fred L. , Killoran Joseph H. , Kozono David E. , Wagar Matthew , Wee Jon O. , Mak Raymond H. 
Published: November 2016

Objectives:
Tumor control (TC), toxicity and survival, following stereotactic body radiation therapy (SBRT) were compared between patients with and without a prior lung resection (PLR).

Materials and Methods:
The study is comprised of 130 patients with 141 peripheral tumors treated with SBRT at our institution from 2009 to 2013. Primary TC and lobar control (LC) were defined per RTOG 0236. Toxicity was scored using Common Terminology Criteria for Adverse Events version 4.0. Survival/TC and toxicity were compared between patients with and without PLR using the Kaplan-Meier method and cumulative incidence, respectively. Fine and Gray regression was used for univariable/multivariable analysis for radiation pneumonitis (RP).

Results:
Of the 130 patients with median age 70 years (range, 42 to 93 y), 50 had undergone PLR (median time between PLR and SBRT: 33 mo; range, 1 to 206), including pneumonectomy (12%), lobectomy (46%), wedge resection (42%). With a median follow-up of 21 months in survivors, the PLR group had better TC (1-y 100% vs. 93%; P<0.01) and increased grade ≥2 (RP; 1-y 12% vs. 1%; P<0.01). OS was not significantly different between the 2 groups (1-y 91% vs. 85%; P=0.24). On univariable/multivariable analyses, biologically effective dose was associated with TC (hazard ratios, 0.97; 95% confidence interval, 0.94-0.999; P=0.04). Chemotherapy use was associated with grade ≥2 RP for all patients (hazard ratios, 14.92; 95% confidence interval, 5.68-39.21; P<0.0001) in multivariable analysis. PLR was not associated with increased RP in multivariable analysis.

Conclusions:
Patients with PLR who receive lung SBRT for lung tumors have high local control and relatively low toxicity. SBRT is an excellent option to treat second lung tumors or pulmonary metastases in patients with PLR.
The Relation of White-on-White Standard Automated Perimetry, Short Wavelength Perimetry, and Optic Coherence Tomography Parameters in Ocular Hypertension
Authors: Başkan Ceyda , Köz Özlem G. , Duman Rahmi , Gökçe Sabite E. , Yarangümeli Ahmet A. , Kural Gülcan 
Published: November 2016

Purpose:
The purpose of this study is to examine the demographics, clinical properties, and the relation between white-on-white standard automated perimetry (SAP), short wavelength automated perimetry (SWAP), and optical coherence tomographic (OCT) parameters of patients with ocular hypertension.

Materials and Methods:
Sixty-one eyes of 61 patients diagnosed with ocular hypertension in the Ankara Numune Education and Research Hospital ophthalmology unit between January 2010 and January 2011 were included in this study. All patients underwent SAP and SWAP tests with the Humphrey visual field analyser using the 30.2 full-threshold test. Retinal nerve fiber layers (RNFL) and optic nerve heads of patients were evaluated with Stratus OCT.

Results:
Positive correlation was detected between SAP pattern standard deviation value and average intraocular pressure (P=0.017), maximum intraocular pressure (P=0.009), and vertical cup to disc (C/D) ratio (P=0.009). Positive correlation between SWAP median deviation value with inferior (P=0.032), nasal (P=0.005), 6 o’clock quadrant RNFL thickness (P=0.028), and I
max/T
avg ratio (P=0.023) and negative correlation with S
max/N
avg ratio (P=0.005) were detected. There was no correlation between central corneal thickness and peripapillary RNFL thicknesses (P>0.05).

Conclusions:
There was no relation between SAP median deviation, pattern standard deviation values and RNFL thicknesses and optic disc parameters of the OCT. By contrast significant correlation between several SWAP parameters and OCT parameters were detected. SWAP appeared to outperform achromatic SAP when the same 30-2 method was used.