bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histopathological changes in testicular lesions in cats
Authors: Hill Fraser I , Tse May PY , Mills Steve W , Sandy Jeanine R , Elsohaby Ibrahim , Barrs Vanessa R 
Published: September 2024

Objectives The aim of this retrospective study was to describe the neoplastic and non-neoplastic lesions seen on histopathological examination of cat testes in Hong Kong between 2018 and 2024. Methods A total of 26 single or dual testes samples were collected from 18 cats by veterinarians at 14 veterinary clinics and submitted for histopathological examination. Laboratory records, including signalment, lesion location, age, breed and histopathological findings, were reviewed for each cat. Results Neoplastic testicular lesions were seen in three older cats (median age 8.5 years; range 3–17) compared with 18 non-neoplastic lesions in 15 cats (median age 1 year; range 0.5–3). The most common non-neoplastic lesions included inflammation (in the testes, epididymis, tunics and ductus deferens), cryptorchidism, and one case each of polyorchidism and epididymal cyst formation. Two of the testes with inflammation were identified on immunohistochemical staining as feline coronavirus-infected and one pair of testes was associated with the presence of extracellular Gram-negative bacteria at the lesion site. Three different neoplastic lesions were identified, one each of Sertoli cell tumour, leiomyoma and fibrosarcoma. Conclusions and relevance Non-neoplastic testicular lesions were most common, including inflammation, cryptorchidism, polyorchidism and epididymal cysts. To our knowledge, leiomyoma and fibrosarcoma have not been reported in cat testes before and represent important differential diagnoses for testicular lesions.
The incidence and trends of proteinuria, azotemia and hypertension in cats receiving toceranib phosphate
Authors: Williams Kimberly , MacDonald-Dickinson Valerie , Matsuyama Arata 
Published: September 2024

Objectives This retrospective study aimed to determine the incidence and trends of proteinuria, elevations in serum creatinine and urea, and systolic blood pressure in cats undergoing treatment with toceranib. Methods In total, 32 cats treated with toceranib for malignancies were analyzed. Cats were included if urinalysis and urine protein:creatinine ratio (UPC) measurements were available at 28 days (T1) and 56 days (T2) after starting the treatment. Cats with concurrent lower urinary tract disease, including urinary tract malignancy, were excluded. Friedman’s ANOVA compared variables between time points, and the Spearman test assessed the correlation between treatment duration and UPC. Results The median starting dose of toceranib was 2.68 mg/kg (range 1.7–3.9). In total, 15 (46.9%) cats received concurrent non-steroidal anti-inflammatory drugs. The most commonly treated tumors were oral squamous cell carcinoma (n = 10) and mast cell tumor (n = 5). None of the 32 cats developed progressive proteinuria or azotemia during the follow-up period (median 56 days; range 56–336). Notably, UPC and serum creatinine were significantly lower at T2 compared with baseline ( P = 0.012 and 0.001, respectively). Among the four cats with baseline proteinuria, UPC decreased over time with or without concurrent telmisartan treatment (n = 2). All four of these cats experienced a reduction in tumor size with toceranib concurrently with their decreased UPC. There was no significant correlation between UPC and the duration of toceranib treatment ( P = 0.089). Blood pressure was not significantly different over the assessed time points. Conclusions and relevance The incidence of proteinuria, renal azotemia and hypertension in cats treated with toceranib for neoplasia appears to be low. Toceranib may be a viable treatment option even in cats with pre-existing proteinuria or renal disease, with careful monitoring of trends recommended.
Impact of vitreomacular interface on intravitreal Brolucizumab efficacy in age-related macular neovascularization
Authors: Ruggeri Maria Ludovica , Toto Lisa , Zeppa Lucio , Gironi Matteo , Quarta Alberto , Venturoni Patrizio , Aharrh-Gnama Agbeanda , Porreca Annamaria , Di Nicola Marta , Mastropasqua Rodolfo 
Published: September 2024

Background This study aimed to assess the influence of vitreoretinal interface (VRI) on the outcome of Brolucizumab intravitreal injections (IVBr) in patients with age-related macular neovascularization (MNV). Methods 40 eyes of 40 patients with active-naive MNV candidates to IVBr were enrolled at the Ophthalmology Clinic of the University “G. d’Annunzio,” Chieti-Pescara, Italy. Based on the VRI condition, 20 patients were included in the G0 group (without evidence of VRI alterations), whereas 20 patients were enrolled in the G1 group (with VRI abnormalities). The primary outcome measures were changes in best-corrected visual acuity (BCVA), central macular thickness (CMT), subfoveal choroidal thickness (SCT), pigment epithelial detachment presence and maximum height (PEDMH), intraretinal fluid (IRF) presence, subfoveal subretinal fluid (SSRF) presence and thickness (SSRFT), subretinal pigment epithelium fluid (SRPEF) presence and SRPEF thickness (SRPEFT). Results There were no significant differences in BCVA and SCT between the two groups, although both parameters significantly changed over time (BCVA p 0.005; SCT p < 0.001). No differences in CMT and PEDMH were found between the two groups. SSRF presence showed differences between the two groups at T4 (p 0.044), and IRF presence showed significant differences over time (p 0.008) in favor of MNV eyes without VRI alterations. Conclusions Concomitant vitreomacular interface disease alterations in eyes treated with IVBr for MNV influenced fluid presence with greater persistence of SSRF and IRF compared to MNV eyes without VRI. Nevertheless, the overall macular thickness and visual function were not significantly different between the two groups.
Autism and emotion recognition technologies in the workplace
Authors: Katirai Amelia 
Published: September 2024

The use of emotion recognition technologies in the workplace is expanding. These technologies claim to provide insights into internal emotional states based on external cues like facial expressions. Despite interconnections between autism and the development of emotion recognition technologies as reported in prior research, little attention has been paid to the particular issues that arise for autistic individuals when emotion recognition technologies are implemented in consequential settings like the workplace. This article examines recent literature on autism and on emotion recognition technologies to argue that the risks of the use of emotion recognition technologies in the workplace are heightened for autistic people. Following a brief overview of emotion recognition technologies, this argument is made by focusing on the issues that arise through the development and deployment of emotion recognition technologies. Issues related to the development of emotion recognition technologies include fundamental problems with the science behind the technologies, the underrepresentation of autistic individuals in data sets and the problems with increasing this representation, and annotation of the training data for the technologies. Issues related to implementation include the invasive nature of emotion recognition technologies, the sensitivity of the data used, and the imposition of neurotypical norms on autistic workers through their use. The article closes with a call for future research on the implications of these emergent technologies for autistic individuals. Lay abstract Technologies using artificial intelligence to recognize people’s emotional states are increasingly being developed under the name of emotional recognition technologies. Emotion recognition technologies claim to identify people’s emotional states based on data, like facial expressions. This is despite research providing counterevidence that emotion recognition technologies are founded on bad science and that it is not possible to correctly identify people’s emotions in this way. The use of emotion recognition technologies is widespread, and they can be harmful when they are used in the workplace, especially for autistic workers. Although previous research has shown that the origins of emotion recognition technologies relied on autistic people, there has been little research on the impact of emotion recognition technologies on autistic people when it is used in the workplace. Through a review of recent academic studies, this article looks at the development and implementation processes of emotion recognition technologies to show how autistic people in particular may be disadvantaged or harmed by the development and use of the technologies. This article closes with a call for more research on autistic people’s perception of the technologies and their impact, with involvement from diverse participants.
How might shared decision-making meetings reduce the need for children to be in care? A rapid realist review
Authors: Stabler Lorna , O'Donnell Chloe , Forrester Donald , Diaz Clive , Willis Simone , Brand Sarah 
Published: September 2024

Summary Meetings to enhance shared decision-making, such as family group conferences, potentially contribute to enhancing meaningful involvement of families. Such meetings are also claimed by some to reduce the need for children to be in care, either by increasing support from family for parents or by identifying care from within the family network. This rapid realist review aims to develop an understanding of how meetings that facilitate shared decision-making between professionals and families might work to safely reduce the need for children to be in care. It identifies mechanisms that are thought to make a difference and contextual factors that influence the impact of identified mechanisms. Findings A comprehensive search of academic and gray literature identified 64 documents spanning seven types of shared decision-making meetings. Data from these papers were collected using an iterative process of juxtaposition, comparison, contrast, and combination with a developing program theory. Data from the literature was supplemented with consultation to ensure relevance to the UK setting. The review identified three key mechanisms that made shared decision-making meetings more likely to be effective in safely reducing children's entry to care: enabling participation and engagement; building trust and reducing shame; enabling participation in decision-making processes. It describes how these work before, during, and after meetings. Applications The findings help us understand the complicated research findings about the relationship between meetings and care entry and provide a theory about what is needed to make such meetings work that is of practical use for practice and future research
Collagen-Based Vascular Closure Device Multicenter Italian Experience in Endovascular Aortic Aneurysm Repair Compared With Suture-Mediated Closure Vascular Device
Authors: Panagrosso Marco , Cavallo Eduardo , Bracale Umberto Marcello , Peluso Antonio , Silvestri Olga , Intrieri Francesco , Molinari Vincenzo , Esposito Antonio , Trimarchi Santi , Settembrini Alberto Maria , Lomazzi Chiara , La Barbera Gaetano , Carbonari Luciano , Angelini Andrea , Morelli Irene , Centonza Eleonora , Berchiolli Raffaella , Troisi Nicola , Scarati Valentina , Artini Valerio , De Vivo Salvatore , Volpe Pietro , Massara Mafalda , Martelli Eugenio 
Published: September 2024

Purpose: The Manta Vascular Closure Device is a novel collagen-based vascular closure device that has been designed specifically for closure of large-bore percutaneous arterial accesses. The aim of this retrospective study is to evaluate the immediate and 30-day outcome of Manta at the completion of endovascular aneurysm repair (EVAR) or thoracic endovascular aortic repair (TEVAR). The hypothesis is that Manta is not inferior in obtaining hemostasis compared with the Perclose ProGlide Suture-Mediated Closure System device. Materials and Methods: We recruited all the percutaneous accesses for (T)EVAR performed from January 2021 to April 2023 by all the Italian Divisions of Vascular Surgery using Manta at the time of data collection (May 2023). The primary outcome is to evaluate the incidence of complications at the puncture site after Manta implantation and at 1 month, and compare this with ProGlide. We applied the STROBE (Strengthening the Reporting of Observational Studies in Epidemiology) criteria for observational studies. Results: Overall, 524 consecutive femoral accesses for (T)EVAR procedures were collected: 355 in the Manta cohort and 169 in the ProGlide cohort, respectively. The size of the sheath was 17.2±2.7 Fr for Manta, 15.7±2.3 Fr for ProGlide (p<0.001). No statistically significant differences between the groups regarding age, sex, body mass index, ultrasound-guided access, femoral calcifications, intraoperative, and 30-day complications. Successful arterial closure at groin puncture sites for (T)EVAR using Manta is 90.5% and 93.1% using ProGlide. Freedom for any reintervention for any complication is 95.5% for Manta and 96% for ProGlide. Conclusion: The 2 vascular closure devices have proved to be similar in terms of complications, without any statistically significant difference, although the median size of the sheaths for (T)EVAR was statistically significantly larger when Manta has been used, compared with ProGlide. Clinical Impact Manta® is effective in the hemostasis of the access sites following the completion of (T)EVAR in this multicenter, retrospective, case-control study on 524 percutaneous femoral accesses. Compared to the more popular Proglide®, the average size of the introducers in the Manta® group was significantly larger than in the Proglide® group.
Primary Healthcare Providers’ Activities in Linking Patients With Chronic Diseases to Community Organizations: A Scoping Review
Authors: Grgurevic Nevena , Chouinard Maud-Christine , Ellefsen Édith , Hudon Émilie , Hudon Catherine 
Published: September 2024

Context: Aging and increasing comorbidities in the population are leading to more complex care for patients and primary healthcare providers. Community organizations (COs) may play a role in the services offered to support patients with chronic diseases (PCDs) but there are currently no clear guidelines to support primary healthcare providers in linking patients to COs. Objectives: The aim of this study was to describe the role of primary healthcare providers regarding linking PCDs to COs by: (1) describing linking activities; and (2) identifying the main facilitators and barriers associated with these activities. Methods: This scoping review was based on the Arksey and O’Malley method, completed by Levac, Colquhoun, and O’Brien. Related keywords were used in 7 databases to search relevant studies. After the initial screening, 135 full texts were assessed for eligibility by 2 reviewers using inclusion/exclusion criteria. Empirical studies describing activities performed by primary healthcare providers in linking PCDs to COs or describing facilitators or barriers to linking activities were included. Studies describing activities linking to other services than COs or located in emergency departments were excluded. Results: In total, 28 studies were included. Information reported in the studies was classified into 8 main linking activities: capacity development, patient identification, assessment, information, planning, referral, follow-up, and collaboration. Facilitators and barriers to these activities were related to intrapersonal characteristics of providers and patients, professional practice, work environment, relationships, and external influences. Healthcare providers’ involvement was often adapted according to their field of practice. Conclusion: This scoping review details the role of primary healthcare providers when linking PCDs to COs in a collaborative and interdisciplinary context, which can be adapted to clinical practice by providers, experts, or stakeholders to support improvement in chronic care management.
Waterpipe Smoking and Lumbar Intervertebral Disc Degeneration: A Pilot Study
Authors: Ishak Hala , Sunna Tarek P. , Assaf Sara A. , Banna Hanin , Khouzami Riad A. , Wang Zhi , Zaatari Ghazi , Rahme Diana , Sakr Carine J. 
Published: September 2024

Study Design Retrospective study. Objective The objective of this study is to investigate the association of waterpipe smoking with lumbar intervertebral disc degeneration (IVDD). Methods This is a retrospective chart review study. A total of 286 adults who underwent a lumbar magnetic resonance imaging (MRI) at a tertiary medical center were included and divided into three groups. Group 1 (n = 125) included non-smokers, group 2 (n = 80) smoked cigarettes only, and group 3 (n = 81) smoked waterpipe only. The intervertebral discs were graded using the Pfirmann disc degeneration grading system. Results The study showed higher lumbar disc degeneration scores for waterpipe and cigarette smokers compared to non-smokers at all spinal levels. Specifically, post hoc analysis showed that there was a significant difference at L1-L2 between cigarette smokers and non-smokers ( P = 0.007) and between waterpipe smokers and non-smokers ( P = 0.013), and a significant difference at L3-L4 and L4-L5 between non-smokers and cigarettes smokers ( P < .001 and P = .029 respectively). Conclusion Waterpipe smoking is associated with lumbar intervertebral disc degeneration.
Telepalliative Care in Home-Based Nursing Care for Older Adults With Metastatic Cancer Post COVID-19: An Ethnoscientific Study
Authors: Sathiyamas Jinpitcha , Mingmalairak Chatchai , Rungroungdouyboon Bunyong , Sri-Ngernyuang Chawakorn 
Published: September 2024

Introduction The post-COVID-19 pandemic caused the whole world to make several changes to the nursing healthcare system. This sudden shift raised questions about telepalliative care in home-based nursing care in the context of healthcare utilization, including meeting the needs of older adults with metastatic cancer. The evidence suggests that telepalliative care in home-based nursing care is acceptable to most advanced practice nurses, but the extent of their use for metastatic cancer patients has not been defined. Objectives To explore the use of telepalliative care in home-based nursing care for older adults with metastatic cancer in central Thailand following the post-COVID-19 pandemic. Methods A qualitative approach with an ethnoscientific design was used to collect data from a purposive sample of 15 advanced practice nurses from May to September 2023. The interview transcripts were analyzed using componential analysis (core coding, categorizing, theme, and emerging theory). Results The componential analysis revealed two themes of telepalliative care in home-based nursing care for older adults with metastatic cancer in the post COVID-19 pandemic. The first theme is telepalliative care delivery, with subthemes of delivering practice, nurse-mediated feedback and supportive care, remote monitoring of real-time emergencies, and transferring medical data. The second theme is advanced practice nurses’ (APN) role in telepalliative nursing care, including the subthemes of virtual monitoring, life-threatening cancer, side effects, caregiving capacity, continuity of care, and long-term care services. The study found that caregiving capacity, continuity of care, and long-term care services were formed of telepalliative care in home-based nursing care for cancer patients following the COVID-19 pandemic. Conclusion Telepalliative care in home-based nursing care is effective in delivering services to older adults with metastatic cancer during the post-COVID-19 pandemic. The findings suggested that remote monitoring of real-time emergencies, life-threatening cancer, and long-term care services are part of telepalliative care in home-based nursing care. Adapting the telepalliative competency standards of advanced practice nurses is needed to ensure high-quality healthcare access for older adults with metastatic cancer during the post-COVID-19 pandemic.
Racial Differences in Breast Cancer Survival Between Black and White Women According to Tumor Subtype: A Systematic Review and Meta-Analysis
Authors: Torres Juliana M. , Sodipo Michelle O. , Hopkins Margaret F. , Chandler Paulette D. , Warner Erica T. 
Published: September 2024

PURPOSE
Despite effective early-detection approaches and innovative treatments, Black women in the United States have higher breast cancer mortality rates compared with White women. The purpose of this systematic review and meta-analysis is to determine the extent of disparities in breast cancer survival between Black and White women according to tumor subtype.

METHODS
A comprehensive database search was performed for full-text, English-language articles published from January 1, 2000, to December 31, 2022. Included studies compared survival between Black and White female patients with breast cancer within subtypes defined by hormone receptor and human epidermal growth factor receptor 2 (HER2)/neu (HER2; now known as ERBB2) status. Random-effects models were used to combine study-specific results and generate pooled relative risks (RRs) and 95% CIs for breast cancer–specific or overall survival (OS). A protocol for this review was registered in PROSPERO (CRD42021268212).

RESULTS
Eighteen studies including 228,885 (34,262 Black; 182,466 White) patients with breast cancer were identified. Compared with White women, Black women had a higher risk of breast cancer death for all tumor subtypes. The summary risk of breast cancer death was 50% higher among hormone receptor-positive HER2-negative [HER2–] tumors (RR, 1.50 [95% CI, 1.30 to 1.72]), 34% higher for hormone receptor+/HER2+ (RR, 1.34 [95% CI, 1.10 to 1.64]), 20% higher for hormone receptor–negative (–)/HER2+ (RR, 1.29 [95% CI, 1.00 to 1.43]), and 17% higher among individuals with hormone receptor–/HER2– tumors (hazard ratio, 1.17; 95% CI, 1.10 to 1.25). Black women also had poorer OS than White women for all subtypes.

CONCLUSION
These results suggest there are both subtype-specific and subtype-independent mechanisms that contribute to disparities in breast cancer survival between Black and White women, which require multilevel interventions to address and achieve health equity.