bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extremal Beltrami Differentials of Non-Landslide Type
Authors: Yao Guowu 
Published: October 2016

AbstractIn this paper it is shown that there are infinitely many extremal Beltrami differentials of non-landside type and non-constant modulus in a Teichmüller equivalence class if the class contains a landslide extremal. The result answers, affirmatively in a stronger sense, a problem posed by Li.
Morphological and molecular characterization of cucullanid nematodes including Cucullanus opisthoporus n. sp. in freshwater fish from the Brazilian Amazon
Authors: Pereira F.B. , Luque J.L. 
Published: October 2016

AbstractMolecular and morphological characterization of two species of Cucullanidae from freshwater fish in Brazil are provided, one of which represented an undescribed taxon. Cucullanus opisthoporus n. sp. was collected in Cichla melaniae from River Xingu, State of Pará, and in C. pinima from River Jamarí, State of Rondônia. Nematodes referable to Cucullanus grandistomis were collected in Oxydoras niger from River Xingu. The new species has an appendage in the tail tip, ventrally covered by small spines, which is an exclusive feature of Cucullanus tucunarensis. However, C. tucunarensis differs from C. opisthoporus n. sp. based upon the relative position of deirids and the excretory pore, which are more posterior from the oesophageal end in the new species. Observations of C. tucunarensis type specimens also revealed features that were wrongly or not reported in the original description. Type specimens of C. grandistomis were observed, although they were poorly preserved. After evaluation of newly collected specimens of C. grandistomis, features unreported in the original description were observed for the first time, including the presence of an intestinal caecum. Thus, C. grandistomis was transferred to Dichelyne. Sequences of the 18S and 28S rRNA genes revealed high genetic similarity between the specimens of C. opisthoporus n. sp. from the two different hosts as well as their genetic distance from Dichelyne grandistomis n. comb. Phylogenetic reconstructions using representatives of Cucullanidae suggested the artificiality of the current morphological system adopted to separate the genera, since most genera were not monophyletic, although the availability of genetic data is still fragmented.
Empathy and aversion: the neural signature of mentalizing in Tourette syndrome
Authors: Eddy C. M. , Cavanna A. E. , Hansen P. C. 
Published: October 2016

BackgroundPrevious studies suggest that adults with Tourette syndrome (TS) can respond unconventionally on tasks involving social cognition. We therefore hypothesized that these patients would exhibit different neural responses to healthy controls in response to emotionally salient expressions of human eyes.MethodTwenty-five adults with TS and 25 matched healthy controls were scanned using fMRI during the standard version of the Reading the Mind in the Eyes Task which requires mental state judgements, and a novel comparison version requiring judgements about age.ResultsDuring prompted mental state recognition, greater activity was apparent in TS within left orbitofrontal cortex, posterior cingulate, right amygdala and right temporo-parietal junction (TPJ), while reduced activity was apparent in regions including left inferior parietal cortex. Age judgement elicited greater activity in TS within precuneus, medial prefrontal and temporal regions involved in mentalizing. The interaction between group and task revealed differential activity in areas including right inferior frontal gyrus. Task-related activity in the TPJ covaried with global ratings of the urge to tic.ConclusionsWhile recognizing mental states, adults with TS exhibit greater activity than controls in brain areas involved in the processing of negative emotion, in addition to reduced activity in regions associated with the attribution of agency. In addition, increased recruitment of areas involved in mental state reasoning is apparent in these patients when mentalizing is not a task requirement. Our findings highlight differential neural reactivity in response to emotive social cues in TS, which may interact with tic expression.
A Novel Examination of Successful Aging Trajectories at the End of Life
Authors: Cosco Theodore D. , Stephan Blossom C.M. , Muniz Graciela , Brayne Carol ,   the CC75C Study Collaboration
Published: October 2016

RÉSUMÉUn indice de vieillissement réussi (SA) a été capturé dans une étude de cohorte longitudinale basée sur la population des personnes de 75 ans et plus, qui a été examiné longitudinalement en utilisant la modélisation d’un mélange de croissance (MMC) pour identifier les groupes ayant des trajectoires similaires utilisant la dernière interview complète de personnes décédées et jusqu’à quatre collections de données précédentes avant la mort. MMC a identifié un modèle avec trois classes. Les classes étaient : haut fonctionnement, pas de déclin (HPD); fonctionnement élevé, baisse progressive (HBP); et un faible fonctionnement, fort baisse (FB). Les individus de la classe HPD étaient significativement plus jeunes à la mort, et à la fin de l’examen, se composait de plus d’hommes, et plus susceptibles d’être mariées, comparativement aux individus HBP et FB. Ces résultats démontrent différentes façons dont les individus peuvent éprouver un vieillissement réussi à la fin de vie. Cette étude fournit le cadre pour la recherche future en ce qui concerne les processus du vieillissement pendant toute la vie, avec des implications importantes pour la politique et la pratique.
Pupillary and affective responses to maternal feedback and the development of borderline personality disorder symptoms
Authors: Scott Lori N. , Zalewski Maureen , Beeney Joseph E. , Jones Neil P. , Stepp Stephanie D. 
Published: October 2016

AbstractEtiological models propose that a biological vulnerability to emotional reactivity plays an important role in the development of borderline personality disorder (BPD). However, the physiological and phenomenological components of emotional reactivity that predict the course of BPD symptoms in adolescence are poorly understood. This prospective study examines pupillary and affective responses to maternal feedback as predictors of BPD symptom development in adolescent girls over 18 months. Fifty-seven 16-year-old girls completed a laboratory task in which they heard recorded clips of their own mothers making critical or praising statements about them, as well as neutral statements that did not pertain to them. Changes in girls’ pupil dilation and subjective affect were assessed throughout the task. The results demonstrated that greater pupillary response to maternal criticism predicted increases in BPD symptoms over time. In addition, greater pupillary and positive affective responses to maternal praise were associated with higher BPD symptoms at age 16 and faster decreases in BPD symptoms over time, but only among girls who heard clips that were rated by independent observers as less praising. The results suggest that emotional reactivity can serve as either a risk or a protective factor depending on context, with differential effects of reactivity to criticism versus praise.
One, no one and one hundred thousand events: Defining and processing events in an inter-disciplinary perspective
Authors: SPRUGNOLI R. , TONELLI S. 
Published: October 2016

AbstractWe present an overview of event definition and processing spanning 25 years of research in NLP. We first provide linguistic background to the notion of event, and then present past attempts to formalize this concept in annotation standards to foster the development of benchmarks for event extraction systems. This ranges from MUC-3 in 1991 to the Time and Space Track challenge at SemEval 2015. Besides, we shed light on other disciplines in which the notion of event plays a crucial role, with a focus on the historical domain. Our goal is to provide a comprehensive study on event definitions and investigate which potential past efforts in the NLP community may have in a different research domain. We present the results of a questionnaire, where the notion of event for historians is put in relation to the NLP perspective.
Detransitivisation as a support strategy for causativebring
Authors: MONDORF BRITTA , SCHNEIDER ULRIKE 
Published: October 2016

This article presents diachronic corpus analyses of causativebring(bringcaus) which provide new insights into a fairly novel research paradigm in language change: the role of ‘Moderate Transitivity Contexts’ (MTCs) as a refuge for waning verbs and as a breeding ground for waxing verbs (see Mondorf 2010, 2011, 2016; Rohdenburg 2014b; Schneider & Mondorf 2015). It argues that the modulation of transitivity serves as a support strategy for a formerly well-established verb that is leaving the language.The potential of semantic transitivity for the development of explanatory principles in language change has been hinted at by Hopper & Thompson (1980: 279). Empirically investigating the diachronic stages of detransitivisation for a recessive English verb we gain first systematic, empirically validated insights into the link between transitivity and language change.This article adduces support for the claim thatbringcaus+to-infinitive has (almost completely) lost its ability to take fully fledged direct objects. There are, however, at least three, partly overlapping contexts, in which this verb can stand its ground: with reflexives, modals and negation. What these contexts have in common is that they reduce the clause's transitivity, defined by Hopper & Thompson (1980: 251) as ‘the effectiveness with which the verbal action takes place’. Assuming that the higher the transitivity, the stronger the effect of the verbal action is on the object, these detransitivised contexts can be interpreted as alleviating the effect of the verbal action.
Testing two processing principles with respect to the extraction of elements out of complement clauses in English
Authors: ROHDENBURG GÜNTER 
Published: October 2016

The present article contrasts two processing principles, the Domain Minimization Principle (e.g. Hawkins 1999, 2004) and the Complexity Principle (e.g. Rohdenburg 1996, 2007b) in structures involving the extraction of postverbal elements out of (competing) complement clauses. The Domain Minimization Principle may be described as a processing tendency which consists in minimizing the size and complexity of various domains including the filler–gap domain in cases like the following:This is a problem (that) they had promised (that) they would tackle. By contrast, the Complexity Principle represents a correlation between processing complexity and grammatical explicitness. It stipulates that more explicit (and typically more bulky) constructional options are favoured in cognitively more complex environments.This article deals with two sets of rival complements. The behaviour of the first group of clausal alternatives is in line with Hawkins’ prediction, though incompatible with the Complexity Principle. However, there is an even larger group of complement pairs whose distribution inside and outside extraction contexts is predicted by the Complexity Principle but unaccounted for by Domain Minimization. Thus, in extraction contexts, the visible effects of the two antagonistic principles are found with virtually complementary ranges of complement types. The article concludes by attempting to account for the kind of division of labour observed between the two principles under scrutiny. It will be suggested among other things that, in English, the marked infinitive (on its own or with an associated NP) enjoys a privileged or target status in extraction contexts.
Using evolutionary tools to search for novel psychoactive plants
Authors: Halse-Gramkow Morten , Ernst Madeleine , Rønsted Nina , Dunn Robert R. , Saslis-Lagoudakis C. Haris 
Published: October 2016

AbstractBioprospecting is the search for valuable products from natural sources. Given that most species are poorly known, a key question is where to search. Ethnodirected bioprospecting approaches use traditional knowledge in the process of selecting plants to screen for desired properties. A complementary approach is to utilize phylogenetic analyses based on traditional uses or known chemistry to identify lineages in which desired properties are most likely to be found. Novel discoveries of plant bioactivity from these approaches can aid the development of treatments for diseases with unmet medical needs. For example, neurological disorders are a growing concern, and psychoactive plants used in traditional medicine may provide botanical sources for bioactivity relevant for treating diseases related to the brain and nervous system. However, no systematic study has explored the diversity and phylogenetic distribution of psychoactive plants. We compiled a database of 501 psychoactive plant species and their properties from published sources. We mapped these plant attributes on a phylogenetic tree of all land plant genera and showed that psychoactive properties are not randomly distributed on the phylogeny of land plants; instead certain plant lineages show overabundance of psychoactive properties. Furthermore, employing a ‘hot nodes’ approach to identify these lineages, we can narrow down our search for novel psychoactive plants to 8.5% of all plant genera for psychoactivity in general and 1–4% for specific categories of psychoactivity investigated. Our results showcase the potential of using a phylogenetic approach to bioprospect plants for psychoactivity and can serve as foundation for future investigations.
Technological change and the evolution of the law of war
Authors: Liivoja Rain 
Published: October 2016

AbstractAdvances in military technology have led many, including the developers of such technology, to propose new regulation. International lawyers have extensively examined the adequacy of the existing law to address emerging technology, but they have devoted relatively little attention in these analyses to the prior development of the law as a result of, or despite, technological change. This essay highlights two challenges that those wishing to undertake such an exercise might encounter. The first of these is the general paucity of serious engagement with the history of international law applicable in armed conflicts and the perpetuation of a particular “origin myth” of international humanitarian law. The second challenge has to do with the controversies about the impact of technology on society in general, and the impact of military technology on warfare in particular. Nevertheless, the essay concludes by pointing towards some of the insight that might be gained from a more history-conscious analysis of the relationship between technology and law in the military context.
Chromatin proteins and RNA are associated with DNA during all phases of mitosis
Authors: L Black Kathryn , Petruk Svetlana , Fenstermaker Tyler K , Hodgson Jacob W , Caplan Jeffrey L , Brock Hugh W , Mazo Alexander 
Published: October 2016

AbstractMitosis brings about major changes to chromosome and nuclear structure. We used recently developed proximity ligation assay-based techniques to investigate the association with DNA of chromatin-associated proteins and RNAs inDrosophilaembryos during mitosis. All groups of tested proteins, histone-modifying and chromatin-remodeling proteins and methylated histones remained in close proximity to DNA during all phases of mitosis. We also found that RNA transcripts are associated with DNA during all stages of mitosis. Reduction of H3K27me3 levels or elimination of RNAs had no effect on the association of the components of PcG and TrxG complexes to DNA. Using a combination of proximity ligation assay-based techniques and super-resolution microscopy, we found that the number of protein–DNA and RNA–DNA foci undergoes significant reduction during mitosis, suggesting that mitosis may be accompanied by structural re-arrangement or compaction of specific chromatin domains.
Single-cell lineage tracing in the mammary gland reveals stochastic clonal dispersion of stem/progenitor cell progeny
Authors: Davis Felicity M. , Lloyd-Lewis Bethan , Harris Olivia B. , Kozar Sarah , Winton Douglas J. , Muresan Leila , Watson Christine J. 
Published: October 2016

AbstractThe mammary gland undergoes cycles of growth and regeneration throughout reproductive life, a process that requires mammary stem cells (MaSCs). Whilst recent genetic fate-mapping studies using lineage-specific promoters have provided valuable insights into the mammary epithelial hierarchy, the true differentiation potential of adult MaSCs remains unclear. To address this, herein we utilize a stochastic genetic-labelling strategy to indelibly mark a single cell and its progenyin situ, combined with tissue clearing and 3D imaging. Using this approach, clones arising from a single parent cell could be visualized in their entirety. We reveal that clonal progeny contribute exclusively to either luminal or basal lineages and are distributed sporadically to branching ducts or alveoli. Quantitative analyses suggest that pools of unipotent stem/progenitor cells contribute to adult mammary gland development. Our results highlight the utility of tracing a single cell and reveal that progeny of a single proliferative MaSC/progenitor are dispersed throughout the epithelium.
Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
Authors: Ölmezer Gizem , Levikova Maryna , Klein Dominique , Falquet Benoît , Fontana Gabriele Alessandro , Cejka Petr , Rass Ulrich 
Published: October 2016

AbstractCells have evolved mechanisms to protect, restart and repair perturbed replication forks, allowing full genome duplication, even under replication stress. Interrogating the interplay between nuclease-helicase Dna2 and Holliday junction (HJ) resolvase Yen1, we find the Dna2 helicase activity acts parallel to homologous recombination (HR) in promoting DNA replication and chromosome detachment at mitosis after replication fork stalling. Yen1, but not the HJ resolvases Slx1-Slx4 and Mus81-Mms4, safeguards chromosome segregation by removing replication intermediates that escape Dna2. Post-replicative DNA damage checkpoint activation in Dna2 helicase-defective cells causes terminal G2/M arrest by precluding Yen1-dependent repair, whose activation requires progression into anaphase. These findings explain the exquisite replication stress sensitivity of Dna2 helicase-defective cells, and identify a non-canonical role for Yen1 in the processing of replication intermediates that is distinct from HJ resolution. The involvement of Dna2 helicase activity in completing replication may have implications for DNA2-associated pathologies, including cancer and Seckel syndrome.
Simulating the exchange of Majorana zero modes with a photonic system
Authors: Xu Jin-Shi , Sun Kai , Han Yong-Jian , Li Chuan-Feng , Pachos Jiannis K. , Guo Guang-Can 
Published: October 2016

AbstractThe realization of Majorana zero modes is in the centre of intense theoretical and experimental investigations. Unfortunately, their exchange that can reveal their exotic statistics needs manipulations that are still beyond our experimental capabilities. Here we take an alternative approach. Through the Jordan–Wigner transformation, the Kitaev's chain supporting two Majorana zero modes is mapped to the spin-1/2 chain. We experimentally simulated the spin system and its evolution with a photonic quantum simulator. This allows us to probe the geometric phase, which corresponds to the exchange of two Majorana zero modes positioned at the ends of a three-site chain. Finally, we demonstrate the immunity of quantum information encoded in the Majorana zero modes against local errors through the simulator. Our photonic simulator opens the way for the efficient realization and manipulation of Majorana zero modes in complex architectures.
Genetic variation in the insulin, insulin-like growth factor, growth hormone, and leptin pathways in relation to breast cancer in African-American women: the AMBER consortium
Authors: Ruiz-Narváez Edward A , Lunetta Kathryn L , Hong Chi-Chen , Haddad Stephen , Yao Song , Cheng Ting-Yuan David , Bensen Jeannette T , Bandera Elisa V , Haiman Christopher A , Troester Melissa A , Ambrosone Christine B , Rosenberg Lynn , Palmer Julie R 
Published: October 2016

AbstractThe insulin/insulin-like growth factor (IGF) system and related pathways such as growth hormone, and leptin signaling have a key role in cancer development. It is unclear how germline variation in these pathways affects breast cancer risk. We conducted gene-based analyses of 184 genes in the insulin/IGF, growth hormone, and leptin pathways to identify genetic variation associated with risk of breast cancer overall, and for estrogen receptor (ER) subtypes. Tag single-nucleotide polymorphisms (SNPs) for each gene were selected and genotyped on a customized Illumina SNP array. Imputation was carried out using 1000 Genomes haplotypes. The analysis included 91,627 SNPs genotyped or imputed in 3,663 breast cancer cases, (1,983 ER-positive and 1,098 ER-negative) and 4,687 controls from the African American Breast Cancer Epidemiology and Risk consortium, a collaborative project of four large studies of breast cancer in African-American women (Carolina Breast Cancer Study, Black Women's Health Study, Women's Circle of Health Study, and Multiethnic Cohort). We used a multi-locus adaptive joint test to determine the association of each gene with overall breast cancer and ER subtypes. The most significant gene associations (P⩽0.01) were BAIAP2 and CALM2 for overall breast cancer; BAIAP2 and CSNK2A1 for ER+ breast cancer; and BRAF, BAD, and MAPK3 for ER− breast cancer. The association of BAD with ER− breast cancer was explained by a two-SNP risk model; all other associations were best explained by one-SNP risk models. In total, six genes and seven SNPs had suggestive associations with overall breast cancer or ER subtypes in African-American women.
Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway
Authors: Wang Gang , Cao Rui , Wang Yongzhi , Qian Guofeng , Dan Han C. , Jiang Wei , Ju Lingao , Wu Min , Xiao Yu , Wang Xinghuan 
Published: October 2016

AbstractSimvastatin is currently one of the most common drugs for old patients with hyperlipidemia, hypercholesterolemia and atherosclerotic diseases by reducing cholesterol level and anti-lipid properties. Importantly, simvastatin has also been reported to have anti-tumor effect, but the underlying mechanism is largely unknown. We collected several human bladder samples and performed microarray. Data analysis suggested bladder cancer (BCa) was significantly associated with fatty acid/lipid metabolism via PPAR signalling pathway. We observed simvastatin did not trigger BCa cell apoptosis, but reduced cell proliferation in a dose- and time-dependent manner, accompanied by PPARγ-activation. Moreover, flow cytometry analysis indicated that simvastatin induced cell cycle arrest at G0/G1 phase, suggested by downregulation of CDK4/6 and Cyclin D1. Furthermore, simvastatin suppressed BCa cell metastasis by inhibiting EMT and affecting AKT/GSK3β. More importantly, we found that the cell cycle arrest at G0/G1 phase and the alterations of CDK4/6 and Cyclin D1 triggered by simvastatin could be recovered by PPARγ-antagonist (GW9662), whereas the treatment of PPARα-antagonist (GW6471) shown no significant effects on the BCa cells. Taken together, our study for the first time revealed that simvastatin inhibited bladder cancer cell proliferation and induced cell cycle arrest at G1/G0 phase via PPARγ signalling pathway.