bluuebunny/crossref_metadata_2025_split huggingface dataset:
Body Composition and Ectopic Lipid Changes With Biochemical Control of Acromegaly
Authors: Bredella Miriam A , Schorr Melanie , Dichtel Laura E , Gerweck Anu V , Young Brian J , Woodmansee Whitney W , Swearingen Brooke , Miller Karen K 
Published: September 2017

Abstract

Context
Acromegaly is characterized by growth hormone (GH) and insulinlike growth factor-1 (IGF-1) hypersecretion, and GH and IGF-1 play important roles in regulating body composition and glucose homeostasis.

Objective
The purpose of our study was to investigate body composition including ectopic lipids, measures of glucose homeostasis, and gonadal steroids in patients with active acromegaly compared with age-, body mass index (BMI)−, and sex-matched controls and to determine changes in these parameters after biochemical control of acromegaly.

Design
Cross-sectional study of 20 patients with active acromegaly and 20 healthy matched controls. Prospective study of 16 patients before and after biochemical control of acromegaly.

Main Outcome Measures
Body composition including ectopic lipids by magnetic resonance imaging/proton magnetic resonance spectroscopy; measures of glucose homeostasis by an oral glucose tolerance test; gonadal steroids.

Results
Patients with active acromegaly had lower mean intrahepatic lipid (IHL) and higher mean fasting insulin and insulin area under the curve (AUC) values than controls. Men with acromegaly had lower mean total testosterone, sex hormone−binding globulin, and estradiol values than male controls. After therapy, homeostasis model assessment of insulin resistance, fasting insulin level, and insulin AUC decreased despite an increase in IHL and abdominal and thigh adipose tissues and a decrease in muscle mass.

Conclusions
Patients with acromegaly were characterized by insulin resistance and hyperinsulinemia but lower IHL compared with age-, BMI-, and sex-matched healthy controls. Biochemical control of acromegaly improved insulin resistance but led to a less favorable anthropometric phenotype with increased IHL and abdominal adiposity and decreased muscle mass.
An Adaptive Large Neighborhood Search for the Location-routing Problem with Intra-route Facilities
Authors: Schiffer Maximilian , Walther Grit 
Published: September 2017

Recent research on location-routing problems has been focusing on locating facilities as the starting and end point of routes. In this paper, we investigate a new type of location-routing problem. In the location-routing problem with intra-route facilities, the location of depots is known, whereas the location of facilities for intermediate stops has to be determined to keep vehicles operational. We present an adaptive large neighborhood search which is enhanced by local search and dynamic programming components, and derive new penalty functions for time-efficient neighborhood evaluation. We show that this algorithm is suitable for solving various problems with intra-route facilities by deriving new best known solutions for the recently published electric location-routing problem with time windows and partial recharging, as well as for the battery swap station electric vehicle location-routing problem. Additionally, we create new real-world benchmark instances and show results as well. Furthermore, we assess the competitiveness of our algorithm on the electric vehicle routing problem with time windows for full and partial recharging, and derive new best known solutions for both problem variants. The online appendix is available at https://doi.org/10.1287/trsc.2017.0746 .
“Mall”-deando la ciudad: 24 años de territorialización de los malls en Costa Rica
Authors: Jiménez Corrales Andrés 
Published: September 2017

La territorialización de los malls en Costa Rica inicia en el año 1993 con la inauguración de Multiplaza Escazú, en la Gran Área Metropolitana de Costa Rica. De este año al año 2017 se contabiliza un total de 14 malls. En este artículo se hará un recorrido sobre las principales características que tienen los malls; se caracterizará la llegada del primer mall al país y se desarrollará un análisis de la evolución espacio-temporal que han tenido estas infraestructuras en la GAM. Por último, se hace un repaso de algunos de los reclamos y respuestas ciudadanas que se han dado ante la construcción de un mall.
Entrevista a Jorge Bertheau
Authors: Grané Jorge 
Published: September 2017

Jorge Bertheau construyó su casa de ladrillo, en Escazú, hace 35 años. Estudió Arquitectura en México y, a su regreso, trabajó en el estudio de Rafael “Felo” García con quien entabló una profunda amistad. Más adelante, Edgar Brenes se unió a ellos y juntos gestaron la idea de fundar la Escuela de Arquitectura de la Universidad de Costa Rica (UCR), la que tuvo poco apoyo por parte de las autoridades universitarias. Con una beca ofrecida por Inglaterra, Jorge Bertheau y Felo García fueron a ese país a conocer programas de estudio. Más tarde se les unió Edgar Brenes. A su regreso, en 1971, se abrió la Escuela, con la consigna de “aprender a aprender”. La flamante Escuela tuvo detractores y seguidores. Entre estos últimos se destacó la figura del Ingeniero Walter Sagot. A la lucha por la supervivencia de la Escuela, Bertheau la califica como “el momento heroico” de la misma, que luego se diluyó con otra gente y otras ideas. Muchos profesores se acercaron, en sus inicios, con entusiasmo, para apoyar la misión de la Escuela y así se formaron, con éxito los primeros arquitectos costarricenses.
Transplantology of the 21st century: High technologies in medicine and innovations in biomedical science
Authors: Gautier S. V. 
Published: September 2017

Review of the main research areas and the most significant results obtained in recent years in the Federal Research Center of Transplantology and Artificial Organs including heart transplantation, lung transplantation, the evolution of liver transplantation and kidney transplantation is presented. The article also describes advanced developments in the field of creating artificial organs – artificial circulatory support systems – and regenerative medicine, nano- and cellular technologies, the creation of bioartificial organs.
Specific efficiency of microemulsion matrix transdermal delivery system of insulin (experimental model of diabetes mellitus typeI)
Authors: Kuznetsova E. G. , Kuryleva O. M. , Salomatina L. A. , Skaletskaya G. N. , Skaletskiy N. N. , Sevastianov V. I. 
Published: September 2017

Aim. To study the specific activity of the microemulsion form of the matrix insulin transdermal delivery system in vivo on the experimental streptozotocin model of type I diabetes.Materials and methods.Male rats (n = 25) were randomized to the experimental and control groups. TDS insulin with a microemulsion composition was applicated to the animals of the experimental group (n = 15) for 4 days with daily replacement of TDS and control of the glycemia level. The glycemia level of the control group rats (n = 10) was determined throughout the experiment. The blood glucose concentration was measured using glucometer One Touch Select (USA). Results.The average blood glucose level in experimental group was 28.4 ± 2.3 mmol/l before application of TDS insulin. The average glycemic index was 21.2 ± 3.1 mmol/l (p < 0.001) during of TDS application. The blood glucose decrease was 26 ± 8% relative to baseline values. The glycemia was 28.4 ± 1.4 mmol/l in the control group rats throughout the experiment.Conclusion.A significant decrease of blood glucose level with TDS insulin application in rats with experimental type 1 diabetes demonstrates the existence of the specific activity of the microemulsion matrix transdermal delivery system of insulin.
In situ crosslinkable hydrogels for engineered cellular microenvironments
Authors: Park Kyung Min , Park Ki Dong , Sevastianov V. I. , Nemetz E. A. , Vasilets V. N. 
Published: September 2017

In situ crosslinkable hydrogels have been widely used as therapeutic implants and vehicles for a broad range of biomedical applications including tissue regenerative medicine because of their biocompatibility and easiness of encapsulation of cells or signaling molecules during hydrogel formation. Recently, these hydrogel materials have been widely utilized as an artificial extracellular matrix (aECM) because of its structural similarity with the native extracellular matrix (ECM) of the human body and its multi-tunable properties. Various synthetic, natural, and semisynthetic hydrogels have been developed as engineered cellular microenvironments by using various crosslinking strategies. In this review, we discuss how in situ forming hydrogels are being created with tunable physical, chemical, and biological properties. In particular, we focus on emerging techniques to apply advanced hydrogel materials for engineered cellular microenvironments.
Application of tissue engineering technology for formation of human articular cartilage in perfusion bioreactor
Authors: Sevastianov V. I. , Basok Yu. B. , Grigoriev A. M. , Kirsanova L. A. , Vasilets V. N. 
Published: September 2017

Formation of tissue-engineered construct was performed in a specially developed bioreactor. At first, a cellengineered construct of human cartilage tissue consisting of biopolymer microstructured collagen-containing hydrogel, mesenchymal stromal cells of human adipose tissue (hADMSCs) and induction chondrogenic culture medium was prepared and placed in a perfusion bioreactor. As a result, on the 16th day of the study hADMSCs obtain a flattened shape typical for chondroblasts and demonstrate high proliferative activity with the formation of their own extracellular matrix. Histological analysis of the cultured system indicates the beginning of the formation of a tissue-engineered construct of human cartilage tissue.
Apresentação
Authors: Oliveira Júnior Wenceslao Machado de , Girardi Gisele 
Published: September 2017

Primeiro o onde, depois o quem. Na epígrafe acima, o espaço se sobrepõe à pessoa. Ele é prioritário para o personagem pensar a si mesmo. O onde é a pergunta primária. E ela restará sem resposta. O onde é uma das preocupações geográficas quando se pensa o espaço. Seguindo o pensamento de Doreen Massey, espaço é lugar, é lugar do outro, das trajetórias distintas de nós próprios, com as quais negociamos cotidianamente a existência dos territórios que criamos e onde agimos. A convergência de múltiplas trajetórias configura-se em lugar singular, sempre aberto, em constante devir. Cada encontro de trajetórias se faz em acontecimento. Cada acontecimento é pleno de potencialidades para proliferar. Cada proliferação pode ser traduzida como vida, vida sendo entendida como aquilo que se transforma a si mesma, sempre outra, sempre em devir, em constante perguntar-se “onde estou”? Vida inominável por nunca se saber o quê, pois configurada de conexões com o que está fora de si, no espaço... ao redor... o ao redor sendo cada dia mais amplo.
Pressure Transient Analysis and Inflow Performance for Horizontal Wells
Authors: Kuchuk F. J. , Goode P. A. , Brice B. W. , Sherrard D. W. , Thambynayagam R. K. M. 
Published: September 2017

Abstract
In recent years, pressure transient behavior and inflow performance of horizontal wells have received considerable attention due to the increase in horizontal drilling. In this paper we develop an interpretation methodology for horizontal well pressure transient testing. This methodology is then applied to the interpretation of an actual horizontal well test performed in Prudhoe Bay. The complex geometry associated with horizontal wells makes interpretation of well tests a difficult task. Uniquely determining the system parameters from short time (typical times for vertical well testing) pressure tests is not possible. Combining drawdown and buildup tests, with downhole flowrate measurement is critical for proper interpretation.
We also provide a solution for the Inflow Performance of a horizontal well completed in a rectangular drainage volume, where the well can be of arbitrary length and completed at any location within the drainage volume.
Production Analysis of Marcellus Shale Well Populations Using Public Data: What Can We Learn from The Past?
Authors: Myers Roger R. , Knobloch Timothy S. , Jacot R. Henry , Ayers Kimberly L. 
Published: September 2017

Abstract
The scope of this paper is to use publicly sourced data as a starting point for production analysis of two distinct well populations. The well populations that will be examined are horizontal Marcellus Shale wells (1) frac'd earlier in time with a defined plug-to-plug stage spacing and (2) frac'd at the same time or later in time with 1.5 to 3 times the number of stages, a production acceleration technique known as Reduced Cluster Spacing (RCS).
Public production databases were used to create snap shots of completion activity over time. To speed work flow, a more robust and regularly updated commercially available database that contains both completion and production data was used. Two distinct populations of wells for analysis were identified. A conservative decline curve analysis (DCA) was made to forecast estimated ultimate recovery (EUR) for all wells using only public data. For selected wells, reciprocal production rate versus square root of time plots were generated.
This paper will attempt to answer the following questions: (1) were statistically meaningful populations of both stimulation techniques found to exist; (2) how much production uplift did RCS achieve both early on and later time; (3) was there a real increase in EUR; (4) was there a difference in stimulation efficiency; and, (5) what can we learn by plotting P10, P50, and P90 values and EUR distribution curves for specific well populations.
To the authors' knowledge this would be the first SPE paper to explore this topic over such large Marcellus Shale well populations in Pennsylvania.
Measurement of the Marcellus Shale Properties
Authors: Elsaig M. , Black S. , Aminian K. , Ameri S. 
Published: September 2017

Abstract
Even though the advances in horizontal drilling and hydraulic fracturing techniques have unlocked the gas contained in Marcellus shale, the quantification of the petrophysical properties remain challenging due to complex nature of the shale. Shale permeability is commonly measured by the unsteady state methods, such as pulse-decay or GRI methods, because the shale has a permeability in nano-Darcy range. The permeability values by determined by these techniques have been found often to have large margin of uncertainty as a result of inconsistent experimental protocols and the complex interpretations methods.
In this study, petrophysical properties of the Marcellus shale core plugs were measured using an innovative laboratory setup, referred to as Precision Petrophysical Analysis Laboratory (PPAL). PPAL is designed to accurately measure the petrophysical properties of ultra-low permeability core plugs under the reservoir conditions. PPAL measurements are performed under steady-state isothermal conditions flow conditions and the analysis of the results do not require complicated interpretations. The key advantage of the PPAL is the capability to measure the permeability and porosity of the shale core plugs under a wide range of confining and pore pressures. In addition, the impact of gas adsorption (or desorption) on the measurements can be monitored. The core plugs used in this study were made available through the Marcellus Shale Energy and Environment Laboratory (MSEEL), a dedicated field laboratory in the Marcellus Shale. MSEEL has been established to undertake field and laboratory research to advance and demonstrate new subsurface technologies and to enable surface environmental studies related to unconventional energy development. The filed site is owned and operated by Northeast Natural Energy, LLC and contains several horizontal Marcellus Shale wells. In addition, a vertical well has been drilled specifically for obtaining core, log, and other data for scientific purposes (science well).
The results of the core plug permeability measurements indicated that that the permeability values decline as the gas (pore) pressure increases. Reliable values of the absolute permeability can be obtained by the application of the double-slippage correction for all pore pressure ranges but more specifically for pore pressures below 900 psia. Klinkenberg correction on the other hand, can only provide reliable values for the absolute permeability when the pore pressures are above 900 psia. The determined absolute permeability values were found to be impacted by the net stress. The analysis stress data with the aid of Walsh plot provided the estimates of the fracture (fissure) closure pressure. The closure pressure was found to be dependent on the absolute permeability.
Case Study on Wellbore Integrity for Two Fields with Wells Exposed to CO2 in the Subsurface in the Midwest U.S.
Authors: Markiewicz J. D. , Sminchak J. R. , Moody M. A. 
Published: September 2017

Abstract
The objective of the research presented in this paper was to examine direct evidence of well conditions to determine wellbore integrity factors and mitigation for oil and gas wells exposed to carbon dioxide (CO2) in the subsurface. This project involved identifying the nature and severity of well defects such as poor or permeable cement, microannulus occurrence, cracks, and mechanical defects, through a combination of sustained casing pressure testing and well history review. Two producing fields were used as case studies to explore wellbore integrity: a Michigan Basin site and an Appalachian Basin site. These sites contain wells that have been exposed to injected or naturally-occurring CO2 over several decades and are therefore good candidates for researching wellbore integrity and sustained casing pressure.
Gas sample analysis, field surveys of well conditions, cement bond logs, well records, and sustained casing pressure build-up tests were used to quantify wellbore integrity factors. This research improves understanding the viability of CO2 injection projects and safe, reliable, and environmentally responsible operations.
Growth in CO2-enhanced oil recovery (EOR) has led to an increased demand for information about operational safety and the integrity of wells that have been exposed to CO2 due to injection or natural sources. Addressing this concern requires knowledge of the wellbore construction and local geology in relation to potential for corrosion of wellbore materials and migration of CO2. These aspects factor into site characterization, field management, and well plugging, especially in the Midwest U.S. where many legacy oil and gas wells are located.
History Match Case Study of a Multi PVT Fluid Regime in an Unconventional Tight Sand Reservoir Located in the Powder River Basin
Authors: Gonzalez Daniel , Costello Dan , Loxton Grant 
Published: September 2017

Abstract
Performing a reservoir simulation study for hydraulically fractured horizontal wells in unconventional reservoirs relies on input parameters which are not often well defined. The uncertainty of the input parameters (i.e. completion design, petrophysics, reservoir fluid phase) leads to uncertainty in the resulting history matches and less confidence when using the model results. This paper focuses on the importance of fluid phase characterization in reservoir simulation studies.
One of the challenges the industry currently faces is PVT (pressure-volume-temperature) fluid characterization for tight rock formations. When submitting a production fluid sample for analysis, it is crucial to define an accurate estimate of pressure, temperature, and gas-oil ratio (GOR) in order to place the sample in the appropriate fluid window to yield a representative PVT characterization for use in reservoir simulation studies.
The case study presented in this paper describes a reservoir simulation study in the Powder River Basin with varying fluid regimes across the field (Figure 1). This particular field has three different fluid systems driven by differences in basement heat flow: black oil, volatile oil, and gas condensate. Two different reservoir simulation studies within the same field will be described in this paper. The first reservoir simulation study was developed on an unbounded well in an area of the field interpreted as black oil. The second reservoir simulation study focused on a three well pad in an area interpreted to be gas condensate. Both simulation studies had accompanying PVT reports; unfortunately, irregular early production led to uncertainty in the recombination GOR and the resulting PVT characterizations. Despite modifying several modeling parameters, the model did not respond as expected and a representative history match was difficult to achieve. By re-evaluating the fluid window and PVT conditions, the history match for wells in both studies improved substantially.
Evaluate Sensitivity and Feasibility of Influencing Factors to Increase the Extreme Hydraulic Extension Length of Horizontal Well
Authors: Zhang Bo , Guan Zhichuan , Lu Nu , Hasan A. R. , Xu Chuanbin , Xu Shenqi , Liao Hualin , Zhang Zheng 
Published: September 2017

Abstract
Horizontal well greatly propels the development of unconventional oil and gas. Considering the drilling safety and basic demand of hole cleaning, define length of horizontal well as extreme hydraulic extension length when the drilling fluid pump rate is equal to minimum cutting-carry pump rate and hole cleaning satisfied basic demand. Based on this concept, a prediction model is established according to the relationship among minimum cutting-carry pump rate, bottomhole pressure, circulation pressure loss and drilling pump pressure. This model considers the influence of cuttings on the hydrostatic column pressure, horizontal annular pressure drop and annular geometrical shape. And then this model is used to analyze the impact of well structure, formation property, drilling fluid property, hole cleaning degree and drilling parameters on extreme hydraulic extension length. On the above basis, a new index called ration of dispersion coefficient is introduced to evaluate the sensitivity of each factor. The sensitivity decreases as the sequence of cutting particle size, drilling fluid flow behavior index, acceptable cutting bed height, wellbore diameter, ROP(8-15 m/h), drilling fluid density, drilling string eccentricity, formation fracture pressure, drilling fluid consistency index, well vertical depth and ROP(1-8 m/h). Based on both mitigation effect and feasibility, cutting particle size, drilling fluid flow behavior index, acceptable cutting bed height and rate of penetration are worthy to optimize to prolong EHEL.