bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: MEDICINAL CHEMICAL STUDIES ON ANTIPLASMIN DRUGS. VII. OXA ANALOGS OF 4‐AMINOMETHYLCYCLOHEXANECARBOXYLIC ACID
Authors: ISODA S. , YAMAGUCHI H. , SATOH Y. , HIRATA M. 
Published: April 2016

AbstractEs werden Synthesewege für die Oxaanaloga (II), (IV) und (VII) der 4‐Aminomethylcyclohexancarbonsäure (VIII) angegeben.
ChemInform Abstract: PYRIDO(2,3‐D)PYRIMIDINE ANTIBACTERIAL AGENTS. IV. SYNTHESIS OF METABOLITES OF F PIROMIDIC ACID
Authors: MATSUMOTO J. , MINAMIDA A. , KIMURA Y. , MINAMI S. 
Published: April 2016

AbstractDrei Metaboliten (IIIa), (V) und (VIII) des Baktericids Piromidsäure (I) werden zur Absicherung ihrer Strukturen synthetisiert, da festgestellt worden war, daß das Abbauprodukt (IIIa), das im Blut und Harn von Menschen, die das Baktericid (I) eingenommen hatten, gefunden wurde, stärkere antibakterielle Wirkung zeigt als die Stammverbindung.
ChemInform Abstract: PHOSGENIMINIUM SALTS. PART 28. ANNELATION OF 5 OR 6 MEMBERED HETEROCYCLES TO URACIL DERIVATIVES VIA PHOSGENIMINIUM SALT CONDENSATION
Authors: KOKEL B. , LESPAGNOL C. , VIEHE H. G. 
Published: April 2016

AbstractDas Phosgeniminiumsalz (II) kondensiert mit den Barbitursäuren (I) bzw. (IV) zu den neuen Amidchloriden (III) bzw. (V), die mit den Nucleophilen (VI) zu den entsprechenden Amiden oder Amidinen (VII) reagieren.
ChemInform Abstract: ALKYLATION OF ENAMINES OF BIS(ETHYLTHIO)ACETALDEHYDE: SYNTHESIS OF NORPYRENOPHORIN
Authors: BATES G. S. , RAMASWAMY S. 
Published: April 2016

AbstractAusgehend von Glyoxal (I) erhält man die Enamine (IV), deren Kaliumsalze alkyliert und anschließend zu den Thioacetaldehyden (VI) hydrolysiert werden.
ChemInform Abstract: SYNTHESIS OF DIETHYL, DI‐N‐OCTYL, AND MONO‐ AND DICYCLOHEXANO MACROCYCLIC POLYETHER‐DIESTER LIGANDS
Authors: JOLLEY S. T. , BRADSHAW J. S. 
Published: April 2016

AbstractAus den Polyethylenglykolen (III) entstehen mit 1‐Butenoxid (II) bzw. 1‐Decenoxid (IV) die entsprechenden Addukte (I) bzw. (V).
ChemInform Abstract: HOMOLOGATION OF ORGANOBORANES VIA CARBONYLATION‐REDUCTION
Authors: BROWN H. C. , FORD T. M. , HUBBARD J. L. 
Published: April 2016

AbstractBei der Behandlung mit CO und nachfolgender Lithiumalanat‐Reduktion erhält man aus den substituierten Organoboranen (I) die homologen Verbindungen (II) unter Einschjebung einer Methylengruppe.
ChemInform Abstract: HYDROBORATION. 56. CONVENIENT AND REGIOSPECIFIC ROUTE TO FUNCTIONALIZED ORGANOSILANES THROUGH THE HYDROBORATION OF ALKENYLSILANES
Authors: SODERQUIST J. A. , BROWN H. C. 
Published: April 2016

AbstractTrimethylvinylsilan (I) liefert bei der Hydroborierung nach anschließender Oxidation die beiden isomeren Alkohole (III) und (IV).
ChemInform Abstract: SILICIUMHALTIGE HETEROCYCLISCHE VERBINDUNGEN. 37. MITT. DIREKTE SYNTHESE DES 9,9,10,10‐TETRACHLOR‐9,10‐DISILA‐9,10‐DIHYDRO‐ANTHRACENS AUS O‐DICHLORBENZOL
Authors: CHERNYSHEV E. A. , KOMALENKOVA N. G. , SHAMISHIN L. N. , TURETSKAYA R. A. , LUZGANOVA M. A. 
Published: April 2016

AbstractLeitet man o‐Dichlorbenzo1(I) über einen Silicium‐Kupfer‐Kontakt (Cu‐Anteil 15‐40%), der noch Aktivatoren enthält, dann entsteht hauptsächlich das Tetrachlor‐disila‐anthracen (II).
ChemInform Abstract: REACTION OF ALIPHATIC ALCOHOLS WITH SULFUR AND RED PHOSPHORUS
Authors: MAZITOVA F. N. , KHAIRULLIN V. K. 
Published: April 2016

AbstractReaktionen niederer, mittlerer und höherer Alkohole (Ia) und (Ib), (Ic) und (Id) bzw. (Ie)‐(If) mit Schwefel und rotem Phosphor werden untersucht.
ChemInform Abstract: REACTIONS OF 1,5‐DIKETONES. XXXVIII. 8A‐HYDROXYPERHYDROPHOSPHINOLINES MADE FROM SEMICYCLIC 1,5‐DIKETONES AND PHOSPHINE
Authors: VYSOTSKII V. I. , KALINOV S. M. , TILICHENKO M. N. 
Published: April 2016

AbstractDie Ketone (I) reagieren mit aus Magnesiumphosphid gewonnenem Phosphorwasserstoff zu 8a‐2‐Phenyl‐perhydro‐ phosphinolin‐1‐onen (IIa) bzw. entsprechenden Diphenylderivaten (IIb), die als Stereoisomerengemische anfallen.
ChemInform Abstract: REACTION OF BIS(DIALKYLAMIDO)CHLOROPHOSPHITES WITH IODINE
Authors: GORBATENKO ZH. K. , MITEL'MAN I. E. , FESHCHENKO N. G. 
Published: April 2016

AbstractMethyliodid reagiert mit dem Phosphit (Ia) zum Phosphonium‐iodid (II) das sich zum Derivat (III) hydrolysieren läßt. Tris‐(dimethylamido)‐phosphit (IV) setzt sich mit Iodchlorid (VI) zum entsprechenden Phosphonium‐iodid (VII) um, das sich auch als Nebenprodukt bei der Reaktion zwischen dem Phosphit (Ia) und Iodmethan bildet.
ChemInform Abstract: REACTION OF CHLORAL WITH PHOSPHORUS‐CONTAINING IMINO ESTERS AND AMIDINES
Authors: PETROV K. A. , TIKHONOVA N. A. , BARANOV N. N. , YAKOVLEVA E. V. 
Published: April 2016

AbstractDie Iminoester (I) liefern mit Ammoniumchlorid über die Chlorhydrate (II) phosphorylierte Amidine (III).
ChemInform Abstract: NOVEL SYNTHETIC ASPECTS OF THE PHOSPHONATE‐PHOSPHATE‐REARRANGEMENT. II. SYNTHESIS OF ENOLPHOSPHATES FROM 1‐OXOALKANPHOSPHONATES AND SULFUR YLIDES
Authors: HAMMERSCHMIDT F. , ZBIRAL E. 
Published: April 2016

AbstractDie Acylphosphonate (I) reagieren mit dem Sulfoxoniummethylid (II) unter Bildung der Enolphosphate (IIIa) und (IIIb) sowie der Phosphonophosphate (IVa) und (IVC).
ChemInform Abstract: SYNTHESIS OF MONO‐ AND BISPHOSPHONIUM SALTS CONTAINING PHENYL AND HETEROCYCLIC NUCLEI IN PHOSPHORUS
Authors: BUKACHUK O. M. , MEGERA I. V. , SHEVCHUK M. I. 
Published: April 2016

AbstractBei der Umsetzung der 5‐Brom‐2‐furancarbonsäure (I) mit Triphenylphosphin (II) bei höherer Temperatur tritt Decarboxylierung zum Phosphoniumsalz (III) ein.
ChemInform Abstract: CONDENSATION OF SPIROPHOSPHORANES CONTAINING PHOSPHORUS‐HYDROGEN BOND WITH DIETHYL AZODICARBOXYLATE
Authors: FAUDUET H. , BURGADA R. 
Published: April 2016

AbstractSpirophosphorane vom Typ (I), die bei 20°C mit ihren reaktiven trikoordinierten Tautomeren im Gleichgewicht stehen, reagieren mit dem Azodicarboxylat (II) zu den sehr reaktiven und daher instabilen Hydrazinen (III), die mit Me‐OH(analog mit ande‐ I/i? ren Alkoholen) als Derivate (IV) abgefangen werden; (IIIb) wird auch mit Ethylenglykol als Derivat (V) abgefangen.
ChemInform Abstract: PHOSPHORYLATION OF STERICALLY HINDERED PHENOLS BY PHOSPHORUS(III) DERIVATIVES
Authors: NIFANT'EV E. E. , PREDVODITELEV D. A. , TUSEEV A. P. , GRACHEV M. K. , ZOLOTOV M. A. 
Published: April 2016

AbstractAus den Phenolen (I) und Phosphortrichlorid entstehen die Dichlorphosphite (II).
ChemInform Abstract: HYDROCHLORINATION OF DIALKYL ESTERS OF 1,2‐ALKADIENEPHOSPHONIC ACIDS
Authors: MIKHAILOVA T. S. , ZAKHAROV V. I. , IGNAT'EV V. M. , IONIN B. I. , PETROV A. A. 
Published: April 2016

Abstract1,2‐Alkadien‐phosphonsäure‐ester (I) mit einem tertiären C‐Atom in 3‐Stellung cyclisieren leicht durch HCl‐Gas zu Oxaphosphol‐3‐enen (II).
ChemInform Abstract: SOME PROPERTIES OF 2‐DIALKYLAMINO‐4,5‐BENZO‐1,3,2‐OXAZAPHOSPHOLANES
Authors: PUDOVIK M. A. , MIKHAILOV YU. A. , MALYKH T. A. , AL'FONSOV V. A. , ZAMALETDINOVA G. U. , BUTYEVA E. S. , PUDOVIK A. N. 
Published: April 2016

Abstracto‐Aminophenol (III) reagiert mit Hexa‐ethyl‐triamido‐phosphit (II) zur Spiroverbindung (I) und mit den Dialkylamido‐dichlor‐phosphiten (IV) zu den Oxazaphospholanen (V)..Folgereaktionen des 2‐Diethyl‐4,5‐benzo‐l ,3,2‐oxazaphospholans z.B. mit Schwefel, Acrylnitril (VII) und Diethylamino‐trimethylsilan (X) werden untersucht.
ChemInform Abstract: REDUCTION OF PHOSPHORINANONES WITH FOUR‐COORDINATE PHOSPHORUS CONTAINING SELENOPHOSPHORYL AND PHOSPHORYL GROUPS
Authors: BOSYAKOV YU. G. , LOGUNOV A. P. , KRASNOMOLOVA L. P. , AGASHKIN O. V. , BUTIN B. M. 
Published: April 2016

AbstractDie Reduktion der Phosphorinanone (I) und (IV) mit verschiedenen Reduktionsmitteln unter verschiedenen Reaktionsbedingungen wird untersucht.
ChemInform Abstract: TITANIUM METALLACARBENE‐METALLACYCLOBUTANE REACTIONS: STEPWISE METATHESIS
Authors: HOWARD T. R. , LEE J. B. , GRUBBS R. H. 
Published: April 2016

AbstractDie Reaktion des für Olefinmetathesen erforderlichen Katalysators (I) mit den Olefinen (II) in THF in Gegenwart von 4‐Vinylpyridin‐Styrol‐Copolymeren als Lewisbase liefert die thermisch stabilen Produkte (III).
ChemInform Abstract: TRANSITION‐METAL COMPLEXES OF PYRROLE PIGMENTS. 16. COBALT COMPLEXES OF 1,19‐DIMETHYLDEHYDROCORRINS AS VITAMIN B12 MODELS
Authors: MURAKAMI Y. , AOYAMA Y. , TOKUNAGA K. 
Published: April 2016

AbstractDie Co‐Komplexe eines l,19‐Dimethyl‐AD‐didehydrocorrins und seines Tetradehydro‐Analogen (I) und‐(ID, die beide gegenüber der Grundverbindung Corrin zusätzliche Doppelbindungen an peripheren Stellen und einen weiteren angularen Methylsubstituenten haben, wurden vom Standpunkt der Vitamin‐Blz‐Chemie aus untersucht.
ChemInform Abstract: PLATINUM COMPLEXES OF DIAMINOCARBOXYLATES AND THEIR ETHYL ESTER DERIVATIVES: ANTITUMOR ACTIVITY AND INTERACTION WITH DEOXYRIBONUCLEIC ACID
Authors: INAGAKI K. , KIDANI Y. , SUZUKI K. , TASHIRO T. 
Published: April 2016

AbstractZiel der Arbeit ist es zu klären, ob eine Ladung in Platinkomplexverbindungen verhindert, daß diese Verbindungen eine Antitumorwirkung zeigen, da bisher nur bei neutralen Pt‐Komplexen eine solche Wirkung gefunden wurde.
ChemInform Abstract: A CATIONIC ETHYLENE(HYDRIDO)IRIDIUM(III) COMPLEX
Authors: OLGEMOELLER B. + , BECK W. 
Published: April 2016

AbstractDurch Einwirkung von Ethylen auf eine Suspension des Hydrido‐tetrafluoroborato‐Ir‐Komplexes (I) in CH2Cl2 konnte durch Ligandenaustausch der Titelkomplex (II) als Tetrafluoroborat isoliert werden.
ChemInform Abstract: STUDIES ON THE CONSTITUENTS OF OPHIOPOGONIS TUBERS. VII. SYNTHETIC STUDIES OF F HOMOISOFLAVONOIDS. (3)
Authors: TADA A. , SAITOH T. , SHOJI J. 
Published: April 2016

AbstractEinige Homoisoflavonoide (IV), die aus der Knolle von Ophiopogon Japonicus isoliert worden waren, werden durch Kondensation des Acetophe‐ nons (I) mit dem Aldehyd (II) und anschließende Hydrierung und Ringschlußreaktion synthetisiert.
ChemInform Abstract: TOTAL SYNTHESIS OF (.+‐.)‐ZOAPATANOL
Authors: CHEN R. , ROWAND D. A. 
Published: April 2016

AbstractDie Synthese der (aus Montanoa tomentosa isolierten) Titelverbindung (VIII) erfolgt ausgehend vom Trienol (I) sukzessiv über die Stufen (II), (IIIa), (IIIb), (IIIc), (Va), (Vb) und (VI).
ChemInform Abstract: STEREOCHEMISTRY OF DIHYDROPINOL AND 1,8‐CINEOL DERIVATIVES. PART V. PYROLYSIS S OF PHENYLURETHANES FROM THE DIHYDROPINOL AND CINEOL SYSTEMS
Authors: STARZEMSKA H. , PIATKOWSKI K. 
Published: April 2016

AbstractAus (‐)‐1‐Hydroxy‐ cis‐dihydropinol, (i)‐1‐Hydroxy‐cis‐2,3‐pinol, 8‐Hydroxy‐l ,4‐cineo1, (+)‐endo‐2‐Hy‐ droxy‐1 ,8‐cineol bzw. (i)‐exo‐2‐Hydroxy‐l ,8‐cineol werden mit Phenylisocyanat die Urethane (‐)‐(I), (i)‐(IV), (VI), (+)‐(IX) bzw. (t)‐(X) dargestellt und der Pyrolyse bei 220‐270°C unterworfen: Gebildet werden unter cis‐Eliminierung die Produkte (+)‐(II) und (+)‐(III), (+)‐(V), (VII) und (VIII), (+)‐(II) und (+)‐(III) bzw. (i)‐(XI) und (XII).
ChemInform Abstract: INHIBITORS OF STEROL BIOSYNTHESIS. SYNTHESIS OF 9α‐FLUORO‐3β‐HYDROXY‐5α‐CHOLEST‐8(14)‐EN‐15‐ONE AND RELATED COMPOUNDS
Authors: PARISH E. J. , SCHROEPFER G. J. JUN. 
Published: April 2016

AbstractAus den Cholestenonen (I) enstehen mit Orthoester die Enolether (II).
ChemInform Abstract: NEW SYNTHESIS OF STEROIDAL TETRAHYDROOXAZIN‐2‐ONES
Authors: SCHNEIDER G. , HACKLER L. , DOMBI G. 
Published: April 2016

AbstractDie Aminomethyl‐ und Benzylaminomethyl‐Steroide (Ia) und (Ib) werden zu den Tetrahydrooxazinonen (I I) in ausgezeichneten Ausbeuten cyclisiert.
ChemInform Abstract: THALLIUM IN ORGANIC SYNTHESIS. 59. ALKALOID SYNTHESIS VIA INTRAMOLECULAR NONPHENOLIC OXIDATIVE COUPLING. PREPARATION OF (.+‐.)‐OCOTEINE, (.+‐.)‐ACETOXYOCOXYLONINE, (.+‐.)‐3‐METHOXY‐N‐ACETYLNORNANTENINE, (.+‐.)‐NEOLITSINE, (.+‐.)‐KREYSIGINE, (.+‐.)‐O‐METHYLKREYSIGINE, AND (.+‐.)‐MULTIFLORAMINE
Authors: TAYLOR E. C. , ANDRADE J. G. , RALL G. J. H. , MCKILLOP A. 
Published: April 2016

AbstractReaktion der Modellverbindungen (I) mit dem T1‐Reagenz (II) liefert die verbrückten Diarylsysteme (III).
ChemInform Abstract: A STEREOSPECIFIC SYNTHESIS OF NAPELLINE
Authors: SETHI S. P. , ATWAL K. S. , MARINI‐BETTOLO R. M. , TSAI T. Y. R. , WIESNER K. 
Published: April 2016

AbstractAusgehend von dem Phenol‐Derivat (I) wird nach angegebenem Schema stereospezitisch das "Denudatin"‐System (IVg) aufgebaut, das sich beim Erhitzen in Eisessig in das Napellin‐System (VI) umlagert.
ChemInform Abstract: ANALGESIC NARCOTIC ANTAGONISTS. 3. PREPARATION OF 7β‐METHYLDIHYDROTHEBAINE‐φ
Authors: LELAND D. L. , POLAZZI J. O. , KOTICK M. P. 
Published: April 2016

AbstractThebain (I) reagiert mit Lithiumdimethylcuprat zum Addukt (II) neben geringen Anteilen des Stereoisomeren (III).
ChemInform Abstract: VITAMIN D (CALCIFEROL) AND ITS ANALOGS. 19. REARRANGEMENT OF VINYLALLENES TO 1‐HYDROXYLATED VITAMIN D MODEL SYSTEMS LACKING THE D RING AND SIDE CHAIN
Authors: CONDRAN P. JUN. , OKAMURA W. H. 
Published: April 2016

AbstractAus Cyclohexanon entsteht mit Acetylen das Alkinol (I), das in bekannter Weise zum Bromallen (IIa) umgesetzt wird.
ChemInform Abstract: VITAMIN D (CALCIFEROL) AND ITS ANALOGS. 20. SYNTHESIS OF 3‐DEOXY‐3,3‐DIMETHYL‐1‐HYDROXYVITAMIN D3 FROM VINYLALLENE INTERMEDIATES AND RELATED THERMAL AND CONFIGURATIONAL STUDIES
Authors: MOURINO A. , LEWICKA‐PIEKUT S. , NORMAN A. W. , OKAMURA W. H. 
Published: April 2016

AbstractMethyldimedon (I) wird mit Triphenyldiiodphosphor in das Vinyliodid (II) übergeführt, zu (IIIa) reduziert und zu (IIIb) silyliert.
ChemInform Abstract: NEW PROSTACYCLIN ANALOGS
Authors: BARTMANN W. , BECK G. , KNOLLE J. , RUPP R. H. 
Published: April 2016

AbstractAusgehend von dem geschützten Lacton (I) wird über die angegebenen Zwischenprodukte die Schlüsselverbindung (VIa) dargestellt und mit dem Bromester (VII) zu (VIIIa) kondensiert, aus dem nach A) der Lactimether (VIIIb) gewonnen wird.
ChemInform Abstract: REACTION OF 3‐FORMYLRIFAMYCIN SV WITH FORMALIN IN COMBINATION WITH PRIMARY ALKYLAMINES
Authors: TSUKAMOTO G. , TAGUCHI M. , AIKAWA N. 
Published: April 2016

Abstract3‐Formylrifamycin SV (I) reagiert mit Formalin (II) und primären Alkylaminen (III) zu den Dihydropyrimidoderivaten (IV).
ChemInform Abstract: GENERAL STRATEGY FOR GIBBERELLIN SYNTHESIS: TOTAL SYNTHESES OF (.+‐.)‐GIBBERELLIN A1 AND GIBBERELLIC ACID
Authors: LOMBARDO L. , MANDER L. N. , TURNER J. V. 
Published: April 2016

AbstractDie Synthese von (i)‐Gibberellin A1 (IX) erfolgt ausgehend vom Diendion (Ia) sukzessiv über die Stufen (Ib), (Ic), (IIa), (IIb), (IIIa) [daneben die epimere Säure (IIIb)] (IIIc), (IVa), (IVb), (Va), (Vb), (VIa), (VIb), (VIIa) [daneben das Epimere (VIII)], (VIIb) und (VIIc); die Synthese von Gibberellsäure (X) weiterhin wird ausgehend von (VIII) in zahlreichen Schritten durchgeführt (z.T.
A superior method for cell block preparation for fine‐needle aspiration biopsies
Authors: Balassanian Ronald , Wool Geoffrey D. , Ono Jill C. , Olejnik‐Nave Jolanta , Mah Molinda M. , Sweeney Brenda J. , Liberman Hava , Ljung Britt‐Marie , Pitman Martha B. 
Published: April 2016

BACKGROUNDCell block (CB) techniques for fine‐needle aspiration biopsies (FNABs) vary. A direct comparison of CB techniques with statistical validation was performed to identify the best method.METHODSThree CB techniques were compared: 1) FNAB rinsed in saline and clotted with plasma and thrombin (SPT); 2) FNAB rinsed in formalin and clotted with HistoGel (HG); and 3) FNAB rinsed in formalin, centrifuged, and the pellet captured in a collodion bag (ColB). FNAB was performed on 35 random surgical specimens for smears and each CB technique. A randomized blinded review of hematoxylin and eosin‐stained CB slides was performed and each case was scored on a scale of 1 to 3 for cellularity, preservation, and architecture and the overall best CB was identified. Significance was determined by the Mann‐Whitney U test for nonparametric ordinal data.RESULTSThe mean cellularity score was 1.71 for SPT (standard deviation [SD], 0.89), 1.68 for HG (SD, 0.67), and 3.0 for ColB (SD, 0). The mean preservation score was 1.31 for SPT (SD, 0.58), 1.54 for HG (SD, 0.70), and 2.91 for ColB (SD, 0.37). The mean architecture score was 1.45 for SPT (SD, 0.70), 1.43 for HG (SD, 0.60), and 2.71 for ColB (SD, 0.57). There was no statistical significance noted between SPT or HG when compared for each category. ColB was found to be superior to both SPT and HG when compared for each category (P<.05). The overall best CB was obtained with ColB in 33 of 35 cases (94%), with SPT proving superior in 1 of 35 cases (3%) and HG superior in 1 of 35 cases (3%).CONCLUSIONSColB appears to be a superior technique for CB, yielding greater cellularity, preservation, and architecture in the majority of cases. Cancer Cytopathol 2016;124:508–18. © 2016 American Cancer Society.
Binder‐Free Electrodes of CoAl Layered Double Hydroxide on Carbon Fibers for All‐Solid‐State Flexible Yarn Supercapacitors
Authors: Jagadale Ajay D. , Guan Guoqing , Li Xiumin , Du Xiao , Ma Xuli , Hao Xiaogang , Abudula Abuliti 
Published: April 2016

AbstractYarn supercapacitors have received much attention because of their noticeable role in advanced technologies, such as microrobots, wearable electronic textiles, and implantable medical devices. They can be prepared with different carbon‐based materials, but many devices suffer from low energy densities. Conformally loaded, Faradaically active CoAl‐based layered double hydroxides (CoAl LDH) are loaded onto carbon fiber (CF) yarns to prepare supercapacitors with enhanced capacitance and energy density, avoiding the need for binding agents. The effect of different CoAl LDH loading amounts on morphological, structural, and electrochemical properties is studied, and a loading amount of 2.3 mg cm−2 is found to achieve the maximum specific capacitance of 634.3 F g−1 at a current density of 1 Ag−1. Flexible all‐solid‐state supercapacitor based on CoAl LDH@CF yarns offers excellent areal capacitance (195 mF cm−2) and volumetric energy density (1.6 mWh cm−3) with 94 % cyclic stability after 4000 galvanostatic charge–discharge (GCD) cycles. The energy density and flexibility of this CoAl LDH@CFs yarn‐based all‐solid‐state supercapacitor offer great potential for energy management in flexible electronics.
Modified technique of functional vertical hemilaryngectomy for cancer invading 1 hemicricoid
Authors: Guinchard Anne‐Claude , Monnier Philippe , Jaquet Yves , Monnier Yan , Ikonomidis Christos 
Published: April 2016

AbstractBackgroundPartial laryngectomy techniques are challenging, especially in young patients where function has to be preserved without compromising the oncologic outcome. We present a modified laryngectomy technique indicated for tumors invading one hemicricoid.MethodsVertical hemilaryngectomy with reconstruction of neo‐glottis by hemi trachea and placement of an endolaryngeal silicon prosthesis for a 21‐y old female patient presenting with a synovial sarcoma located on the left arytenoid area.ResultsThe prosthesis was removed at 6 w with tracheotomy closure at 8w post‐op. Patient underwent adjuvant radiotherapy. Functional outcome showed good swallowing without aspiration. Voice was hoarse. At 5 years post‐op the patient is free of recurrence presenting only mild dyspnea upon effort.ConclusionVertical hemilaryngectomy including a hemicricoid is feasible with single stage reconstruction by a hemi‐trachea of 4 to 5 rings intussuscepted into the thyroid cartilage. The functional outcome is good considering oncologic safety and avoidance of a permanent tracheostomy. © 2016 Wiley Periodicals, Inc. Head Neck 38: 1708–1716, 2016
Beware of your Cre‐Ation: lacZ expression impairs neuronal integrity and hippocampus‐dependent memory
Authors: Reichel J.M. , Bedenk B.T. , Gassen N.C. , Hafner K. , Bura S.A. , Almeida‐Correa S. , Genewsky A. , Dedic N. , Giesert F. , Agarwal A. , Nave K.‐A. , Rein T. , Czisch M. , Deussing J.M. , Wotjak C.T. 
Published: April 2016

ABSTRACTExpression of the lacZ‐sequence is a widely used reporter‐tool to assess the transgenic and/or transfection efficacy of a target gene in mice. Once activated, lacZ is permanently expressed. However, protein accumulation is one of the hallmarks of neurodegenerative diseases. Furthermore, the protein product of the bacterial lacZ gene is ß‐galactosidase, an analog to the mammalian senescence‐associated ß‐galactosidase, a molecular marker for aging. Therefore we studied the behavioral, structural and molecular consequences of lacZ expression in distinct neuronal sub‐populations. lacZ expression in cortical glutamatergic neurons resulted in severe impairments in hippocampus‐dependent memory accompanied by marked structural alterations throughout the CNS. In contrast, GFP expression or the expression of the ChR2/YFP fusion product in the same cell populations did not result in either cognitive or structural deficits. GABAergic lacZ expression caused significantly decreased hyper‐arousal and mild cognitive deficits. Attenuated structural and behavioral consequences of lacZ expression could also be induced in adulthood, and lacZ transfection in neuronal cell cultures significantly decreased their viability. Our findings provide a strong caveat against the use of lacZ reporter mice for phenotyping studies and point to a particular sensitivity of the hippocampus formation to detrimental consequences of lacZ expression. © 2016 Wiley Periodicals, Inc.
Biodistribution of polyacrylic acid‐coated iron oxide nanoparticles is associated with proinflammatory activation and liver toxicity
Authors: Couto Diana , Freitas Marisa , Costa Vera Marisa , Chisté Renan Campos , Almeida Agostinho , Lopez‐Quintela M. Arturo , Rivas José , Freitas Paulo , Silva Paula , Carvalho Félix , Fernandes Eduarda 
Published: April 2016

AbstractIron oxide nanoparticles (IONs) have physical and chemical properties that render them useful for several new biomedical applications. Still, so far, in vivo safety studies of IONs with coatings of biomedical interest are still scarce. The aim of this study, therefore, was to clarify the acute biological effects of polyacrylic acid (PAA)‐coated IONs, by determining their biodistribution and their potential proinflammatory and toxic effects in CD‐1 mice. The biodistribution of PAA‐coated IONs in several organs (liver, spleen, kidneys, brain, heart, testes and lungs), the plasma cytokines, chemokine and aminotransferases levels, white blood cell count, oxidative stress parameters, adenosine triphosphate and histologic features of liver, spleen and kidneys were evaluated 24 h after a single acute (8, 20 or 50 mg kg−1) intravenous administration of PAA‐coated IONs in magnetite form. The obtained results showed that these IONs accumulate mainly in the liver and spleen and, to a lesser extent, in the lungs. Although our data showed that PAA‐coated IONs do not cause severe organ damage, an inflammatory process was triggered in vivo, as evidenced by as evidenced by increased neutrophils and large lymphocytes in the differential blood count. Moreover, an accumulation of iron in macrophages of the liver and spleen was observed and hepatic lipid peroxidation was elicited, showing that the IONs are able to induce oxidative stress. The effects of these nanoparticles need to be further investigated regarding the mechanisms involved and the long‐term consequences of intravenous administration of PAA‐coated IONs. Copyright © 2016 John Wiley & Sons, Ltd.