bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparing measurement‐derived (3DVH) and machine log file‐derived dose reconstruction methods for VMAT QA in patient geometries
Authors: Tyagi Neelam , Yang Kai , Yan Di 
Published: February 2017

The purpose of this study was to compare the measurement‐derived (3DVH) dose reconstruction method with machine log file‐derived dose reconstruction method in patient geometries for VMAT delivery. A total of ten patient plans were selected from a regular fractionation plan to complex SBRT plans. Treatment sites in the lung and abdomen were chosen to explore the effects of tissue heterogeneity on the respective dose reconstruction algorithms. Single‐ and multiple‐arc VMAT plans were generated to achieve the desired target objectives. Delivered plan in the patient geometry was reconstructed by using ArcCHECK Planned Dose Perturbation (ACPDP) within 3DVH software, and by converting the machine log file to Pinnacle3 9.0 treatment plan format and recalculating dose with CVSP algorithm. In addition, delivered gantry angles between machine log file and 3DVH 4D measurement were also compared to evaluate the accuracy of the virtual inclinometer within the 3DVH. Measured ion chamber and 3DVH‐derived isocenter dose agreed with planned dose within and , respectively. 3D gamma analysis showed greater than 98% between log files and 3DVH reconstructed dose. Machine log file reconstructed doses and TPS dose agreed to within 2% in PTV and OARs over the entire treatment. 3DVH reconstructed dose showed an average maximum dose difference of 3% ± 1.2% in PTV, and an average mean difference of in OAR doses. The average virtual inclinometer error (VIE) was ‐0.65° ± 1.6° for all patients, with a maximum error of ‐5.16° ± 4.54° for an SRS case. The time averaged VIE was within 1°–2°, and did not have a large impact on the overall accuracy of the estimated patient dose from ACPDP algorithm. In this study, we have compared two independent dose reconstruction methods for VMAT QA. Both methods are capable of taking into account the measurement and delivery parameter discrepancy, and display the delivered dose in CT patient geometry rather than the phantom geometry. The dose discrepancy can be evaluated in terms of DVH of the structures and provides a more intuitive understanding of the dosimetric impact of the delivery errors on the target and normal structure dose.PACS number: 87.55
Frameless stereotactic body radiation therapy for multiple lung metastases
Authors: Li Qilin , Mu Jinming , Gu Wendong , Chen Yuan , Ning Zhonghua , Jin Jianxue , Pei Honglei 
Published: February 2017

Two patients with multiple lung metastases (≥ 5) were treated using frameless stereotactic body radiation therapy (SBRT) on an Elekta Axesse linear accelerator equipped with an interdigitation‐capable multileaf collimator and four‐dimensional cone‐beam CT (4D CBCT). The technique and the early clinical outcomes were evaluated. Patient A with five lung metastases and Patient B with seven lung metastases underwent SBRT (48 Gy/8 fractions for Patient A, 42 Gy/7 fractions for Patient B). The treatments were administered using a 6 MV photon beam. The nominal dose rate was 660 MUs/min. Patients were positioned and immobilized using thermoplastic masks and image guidance was done using 4D CBCT. The targets were delineated on the images of the 4D CT, and the positron emission tomography‐computed tomography (PET‐CT) images were taken as references. A two‐step, volumetric‐modulated arc therapy (VMAT) plan was designed for each patient. Step 1: the lesions in one lung were irradiated by a 210° arc field; Step 2: the rest of the lesions in the other lung were irradiated by a 120° arc field. Plans were evaluated using conformity index (CI) and homogeneity index (HI). Patients were followed up and adverse events were graded according to the Common Terminology Criteria for Adverse Events v4.0 (CTCAE v4.0). The beam‐on time of each treatment was less than 10 min. The CI and HI for the two plans were 0.562, 0.0709 and 0.513, 0.0794, respectively. Pulmonary function deteriorated slightly in both patients, and the patient with seven lung lesions was confirmed to have Grade 1 radiation pneumonitis. The technique was fast, accurate, and well tolerated by patients, and the two‐step plan is a helpful design in reducing the dose to the lungs.PACS numbers: 87.55‐x, 87.56.J‐, 87.56.‐v, 87.56.nk, 87.57.qp
A simpler method for total scalp irradiation: the multijaw‐size concave arc technique
Authors: Inoue Minoru , Konno Masahiro , Ogawa Hirofumi , Harada Hideyuki , Asakura Hirofumi , Fuji Hiroshi , Murayama Shigeyuki , Nishimura Tetsuo 
Published: February 2017

The lateral electron‐photon technique (LEPT) and intensity‐modulated radiation therapy (IMRT) are commonly used for total scalp irradiation. However, the treatment planning and irradiation are laborious and time‐consuming. We herein present the multijaw‐size concave arc technique (MCAT) as a total scalp irradiation method that overcomes these problems. CT datasets for eight patients previously treated for angiosarcoma of the scalp were replanned using MCAT, LEPT, and IMRT. The MCAT was designed with a dynamic conformal arc for the total scalp, with a multileaf collimator to shield the brain. Two additional conformal arcs with a decreased upper‐jaw position of the first dynamic conformal arc were used to reduce the cranial hotspots. The prescribed dose was 40 Gy (2 Gy/fraction) to 95% of the planning target volume (PTV, defined as the total scalp plus a 4 mm margin). MCAT was compared with LEPT and IMRT with respect to the PTV dose homogeneity (D5%–95%), underdosage (V < 90%), overdosage (V > 110%), doses to the brain, and the delivery time and monitor units (MUs) for single irradiation. We were able to formulate treatment plans for all three techniques that could deliver the prescription dose in all patients. MCAT was significantly superior to LEPT with respect to PTV dose homogeneity, overdosage, and underdosage, although MCAT was inferior to IMRT with respect to dose homogeneity and overdosage. The mean brain dose and high‐dosage volume of all three techniques were low, but IMRT provided larger volume to the brain than did the other two techniques in the low dosage region. In MCAT, the mean delivery time could be reduced by approximately half or more, and the mean MUs could be reduced by at least 100 compared to the other two techniques. MCAT can achieve total scalp irradiation with substantially fewer MUs and a shorter delivery time than LEPT and IMRT.PACS number: 87.55.D‐
Dual‐axis rotational coronary angiography can reduce peak skin dose and scattered dose: a phantom study
Authors: Liu Huiliang , Jin Zhigeng , Deng Yunpeng , Jing Limin 
Published: February 2017

The purpose of this study was to evaluate peak skin dose received by the patient and scattered dose to the operator during dual‐axis rotational coronary angiography (DARCA), and to compare with those of standard coronary angiography (SA). An anthropomorphic phantom was used to simulate a patient undergoing diagnostic coronary angiography. Cine imaging was applied on the phantom for 2 s, 3 s, and 5 s in SA projections to mimic clinical situations with normal vessels, and uncomplicated and complicated coronary lesions. DARCA was performed in two curved trajectories around the phantom. During both SA and DARCA, peak skin dose was measured with thermoluminescent dosimeter arrays and scattered dose with a dosimeter at predefined height (approximately at the level of left eye) at the operator's location. Compared to SA, DARCA was found lower in both peak skin dose (range: 44%–82%, p < 0.001) and scattered dose (range: 40%–70%, p < 0.001). The maximal reductions were observed in the set mimicking complicated lesion examinations (82% reduction for peak skin dose, p < 0.001; 70% reduction for scattered dose, p < 0.001). DARCA reduces both peak skin dose and scattered dose in comparison to SA. The benefit of radiation dose reduction could be especially significant in complicated lesion examinations due to large reduction in X‐ray exposure time. The use of DARCA could, therefore, be recommended in clinical practice to minimize radiation dose.PACS numbers: 87.53.‐j, 87.53.Bn, 87.59.‐e, 87.59.C‐, 87.59.cf, 87.59.Dj
Using the ACR CT accreditation phantom for routine image quality assurance on both CT and CBCT imaging systems in a radiotherapy environment
Authors: Hobson Maritza A. , Soisson Emilie T. , Davis Stephen D. , Parker William 
Published: February 2017

Image‐guided radiation therapy using cone‐beam computed tomography (CBCT) is becoming routine practice in modern radiation therapy. The purpose of this work was to develop an imaging QA program for CT and CBCT units in our department, based on the American College of Radiology (ACR) CT accreditation phantom. The phantom has four testing modules, permitting one to test CT number accuracy, slice width, low contrast resolution, image uniformity, in‐plane distance accuracy, and high‐contrast resolution reproducibly with suggested window/levels for image analysis. Additional tests for contrast‐to‐noise ratio (CNR) and noise were added using the polyethylene and acrylic plugs. Baseline values were obtained from CT simulator images acquired on a Phillips Brilliance Big Bore CT simulator and CBCT images acquired on three Varian CBCTs for the imaging protocols most used clinically. Images were then acquired quarterly over a period of two years. Images were exported via DICOM and analyzed manually using OsiriX. Baseline values were used to ensure that image quality remained consistent quarterly, and baselines were reset at any major maintenance or recalibration. Analysis of CT simulator images showed that image quality was within ACR guidelines for all tested scanning protocols. All three CBCT systems were unable to distinguish the low‐contrast resolution plugs and had the same high‐contrast resolution over all imaging protocols. Analysis of CBCT results over time determined a range of values that could be used to establish quantitative tolerance levels for image quality deterioration. While appropriate for the helical CT, the ACR phantom and guidelines could be modified to be more useful in evaluating CBCT systems. In addition, the observed values for the CT simulator were well within ACR tolerances.PACS numbers: 87.57.Q‐, 87.57.qp, 87.57.C‐
In vivo dosimetry for total body irradiation: five‐year results and technique comparison
Authors: Patel Reshma P. , Warry Alison J. , Eaton David J. , Collis Christopher H. , Rosenberg Ivan 
Published: February 2017

The aim of this work is to establish if the new CT‐based total body irradiation (TBI) planning techniques used at University College London Hospital (UCLH) and Royal Free Hospital (RFH) are comparable to the previous technique at the Middlesex Hospital (MXH) by analyzing predicted and measured diode results. TBI aims to deliver a homogeneous dose to the entire body, typically using extended SSD fields with beam modulation to limit doses to organs at risk. In vivo dosimetry is used to verify the accuracy of delivered doses. In 2005, when the Middlesex Hospital was decommissioned and merged with UCLH, both UCLH and the RFH introduced updated CT‐planned TBI techniques, based on the old MXH technique. More CT slices and in vivo measurement points were used by both; UCLH introduced a beam modulation technique using MLC segments, while RFH updated to a combination of lead compensators and bolus. Semiconductor diodes were used to measure entrance and exit doses in several anatomical locations along the entire body. Diode results from both centers for over five years of treatments were analyzed and compared to the previous MXH technique for accuracy and precision of delivered doses. The most stable location was the field center with standard deviations of 4.1% (MXH), 3.7% (UCLH), and 1.7% (RFH). The least stable position was the ankles. Mean variation with fraction number was within 1.5% for all three techniques. In vivo dosimetry can be used to verify complex modulated CT‐planned TBI, and demonstrate improvements and limitations in techniques. The results show that the new UCLH technique is no worse than the previous MXH one and comparable to the current RFH technique.PACS numbers: 87.55.Qr, 87.56.N‐
A dosimetry study precisely outlining the heart substructure of left breast cancer patients using intensity‐modulated radiation therapy
Authors: Fan Ling‐li , Luo Yang‐kun , Xu Jing‐hui , He Ling , Wang Jie , Du Xiao‐bo 
Published: February 2017

The purpose of this study was to evaluate the feasibility of delineating the substructure of the heart by using 64‐slice spiral CT coronary angiography (CTA) in breast cancer patients who underwent left breast‐conserving surgery, and to compare the dosimetric differences between the targets and organs at risk in the prone and supine positions in intensity‐modulated radiation therapy (IMRT) planning. From January to December 2011, ten patients who underwent left breast‐conserving surgery were enrolled in this study. CTA was performed in both the supine and prone positions during the simulation, and conventional scanning without CTA was performed at the same time. Image registration was performed for paired image series using a commercially available planning system. In a conventional image series, the clinical target volume (CTV) of the whole breast, planning target volume (PTV), bilateral lungs (L‐Lung, R‐Lung), spinal cord, contralateral breast (R‐Breast), and heart were delineated. In the CTA image series, the left ventricular (LV) and left anterior descending coronary arteries (LAD) and the planning risk volume (LAD‐PRV) of the LAD (LAD with a 1 cm margin) were outlined. For each patient, two separate IMRT plans were developed for the supine and prone positions. A total of 20 plans were generated. The following indicators were compared: Dmean and D95 for the PTV; Dmean, V5, and V20 for the left lung; Dmean, V10, V20, V25, V30, and V40 for the heart and its substructures (LAD‐PRV, LV); Dmean and V5 for the right lung; and Dmax and Dmean for the right breast. Using CTA to delineate the substructures of the heart is simple and straightforward. Plans for both the prone and supine positions reached the prescribed dose for the PTV without significant differences. Dose distributions were acceptable for both the prone and supine positions. However, the LAD‐PRV, LV, heart, and L‐Lung received smaller doses in the prone position plans than in the supine position plans. The Dmean values reduced by , and in the LAD‐PRV, LV, heart, and L‐Lung. In addition, the V25 lessened and in the LV and heart, while the V20 was decreased , and in the LAD‐PRV, LV, heart, and L‐Lung, respectively. Similarly, the V10 and V30 were reduced by 28.31% () and in the heart, while the V5 was cut back in the L‐Lung. For most Asian women with average‐sized breasts after breast conserving treatment (BCT), prone positioning during IMRT radiation will reduce the dose to the ipsilateral lung, heart, and substructures of the heart, which may reduce the incidence of cardiovascular events after radiotherapy more than radiation therapy performed in a supine position. Using CTA to delineate the substructures of the heart is easy and intuitive. It is cost‐effective and highly recommended for breast cancer IMRT. However, the dose‐volume limits of the heart substructures remain to be determined.PACS number: 87.55.dk
Comparing conformal, arc radiotherapy and helical tomotherapy in craniospinal irradiation planning
Authors: Myers Pamela A. , Mavroidis Panayiotis , Papanikolaou Nikos , Stathakis Sotirios 
Published: February 2017

Currently, radiotherapy treatment plan acceptance is based primarily on dosimetric performance measures. However, use of radiobiological analysis to assess benefit in terms of tumor control and harm in terms of injury to normal tissues can be advantageous. For pediatric craniospinal axis irradiation (CSI) patients, in particular, knowing the technique that will optimize the probabilities of benefit versus injury can lead to better long‐term outcomes. Twenty‐four CSI pediatric patients (median age 10) were retrospectively planned with three techniques: three‐dimensional conformal radiation therapy (3D CRT), volumetric‐modulated arc therapy (VMAT), and helical tomotherapy (HT). VMAT plans consisted of one superior and one inferior full arc, and tomotherapy plans were created using a 5.02 cm field width and helical pitch of 0.287. Each plan was normalized to 95% of target volume (whole brain and spinal cord) receiving prescription dose 23.4 Gy in 13 fractions. Using an in‐house MATLAB code and DVH data from each plan, the three techniques were evaluated based on biologically effective uniform dose (), the complication‐free tumor control probability (), and the width of the therapeutically beneficial range. Overall, 3D CRT and VMAT plans had similar values of (24.1 and 24.2 Gy), while HT had a slightly lower (23.6 Gy). The average values of the index were 64.6, 67.4, and 56.6% for 3D CRT, VMAT, and HT plans, respectively, with the VMAT plans having a statistically significant increase in . Optimal values of were 28.4, 33.0, and 31.9 Gy for 3D CRT, VMAT, and HT plans, respectively. Although values that correspond to the initial dose prescription were lower for HT, after optimizing the prescription level, the optimal became 94.1, 99.5, and 99.6% for 3D CRT, VMAT, and HT, respectively, with the VMAT and HT plans having statistically significant increases in . If the optimal dose level is prescribed using a radiobiological evaluation method, as opposed to a purely dosimetric one, the two IMRT techniques, VMAT and HT, will yield largest overall benefit to CSI patients by maximizing tumor control and limiting normal tissue injury. Using VMAT or HT may provide these pediatric patients with better long‐term outcomes after radiotherapy.PACS number: 87.55.dk
Feasibility and limitations of bulk density assignment in MRI for head and neck IMRT treatment planning
Authors: Chin Alexander L. , Lin Alexander , Anamalayil Shibu , Teo Boon‐Keng Kevin 
Published: February 2017

Head and neck cancers centered at the base of skull are better visualized on MRI than on CT. The purpose of this investigation was to investigate the accuracy of bulk density assignment in head and neck intensity‐modulated radiation therapy (IMRT) treatment plan optimization. Our study investigates dose calculation differences between density‐assigned MRI and CT, and identifies potential limitations related to dental implants and MRI geometrical distortion in the framework of MRI‐only‐based treatment planning. Bulk density assignment was performed and applied onto MRI to generate three MRI image sets with increasing levels of heterogeneity for seven patients: 1) : all water‐equivalent; 2) : included bone with density of ; and 3) : included bone and air. Using identical planning and optimization parameters, MRI‐based IMRT plans were generated and compared to corresponding, forward‐calculated, CT‐based plans on the basis of target coverage, isodose distributions, and dose‐volume histograms (DVHs). Phantom studies were performed to assess the magnitude and spatial dependence of MRI geometrical distortion. ‐based dose calculations overestimated target coverage by 16.1%. Segmentation of bone reduced differences to within 2% of the coverage area on the CT‐based plan. Further segmentation of air improved conformity near air–tissue interfaces. Dental artifacts caused substantial target coverage overestimation even on . Geometrical distortion was less than 1 mm in an imaging volume around scanner isocenter, but up to 4 mm at 17 cm lateral to isocenter. Bulk density assignment in the framework of MRI‐only IMRT head and neck treatment planning is a feasible method with certain limitations. Bone and teeth account for the majority of density heterogeneity effects. While soft tissue is well visualized on MRI compared to CT, dental implants may not be visible on MRI and must be identified by other means and assigned appropriate density for accurate dose calculation. Far off‐center geometrical distortion of the body contour near the shoulder region is a potential source of dose calculation inaccuracy.PACS numbers: 87.61.‐c, 87.55.‐D
Evaluation of a metal artifact reduction algorithm in CT studies used for proton radiotherapy treatment planning
Authors: Andersson Karin M. , Ahnesjö Anders , Dahlgren Christina Vallhagen 
Published: February 2017

Metal objects in the body such as hip prostheses cause artifacts in CT images. When CT images degraded by artifacts are used for treatment planning of radiotherapy, the artifacts can yield inaccurate dose calculations and, for particle beams, erroneous penetration depths. A metal artifact reduction software (O‐MAR) installed on a Philips Brilliance Big Bore CT has been tested for applications in treatment planning of proton radiotherapy. Hip prostheses mounted in a water phantom were used as test objects. Images without metal objects were acquired and used as reference data for the analysis of artifact‐affected regions outside of the metal objects in both the O‐MAR corrected and the uncorrected images. Water equivalent thicknesses (WET) based on proton stopping power data were calculated to quantify differences in the calculated proton beam penetration for the different image sets. The WET to a selected point of interest between the hip prostheses was calculated for several beam directions of clinical relevance. The results show that the calculated differences in WET relative to the reference case were decreased when the O‐MAR algorithm was applied. WET differences up to 2.0 cm were seen in the uncorrected case while, for the O‐MAR corrected case, the maximum difference was decreased to 0.4 cm. The O‐MAR algorithm can significantly improve the accuracy in proton range calculations. However, there are some residual effects, and the use of proton beam directions along artifact streaks should only be used with caution and appropriate margins.PACS numbers: 87.55.D‐, 87.57.cp