bluuebunny/crossref_metadata_2025_split huggingface dataset:
Student-Developed Simulations: Enhancing Cultural Awareness and Understanding Social Determinants of Health
Authors: Cantey Danette S. , Randolph Schenita D. , Molloy Margory A. , Carter Brigit , Cary Michael P. 
Published: April 2017

Background:
National and global initiatives to address the social determinants of health (SDH) are on the rise. On a parallel trajectory, increased cultural awareness is emerging as an integral strategy to improve the understanding of these social contributions to disease states, health inequities, and health disparities.

Method:
Undergraduate nursing students developed modalities and role-played simulations as a teaching and learning strategy. The simulations demonstrated how nurses assess patients' unique needs and offer support and resources regarding patients' socioeconomic, cultural, and environmental needs.

Results:
The student-developed simulations were an interactive teaching and learning strategy that offered several benefits, such as improved interpersonal skills, learned specific nursing roles, and improved cultural awareness.

Conclusion:

Student-developed simulations are an innovative teaching strategy for improving cultural awareness and learning more about SDH. [
J Nurs Educ.
2017;56(4):243–246.]
Early B Cell Progenitors Deficient for GON4L Fail To Differentiate Due to a Block in Mitotic Cell Division
Authors: Barr Jennifer Y. , Goodfellow Renee X. , Colgan Diana F. , Colgan John D. 
Published: April 2017

Abstract
B cell development in Justy mutant mice is blocked due to a precursor mRNA splicing defect that depletes the protein GON4-like (GON4L) in B cell progenitors. Genetic and biochemical studies have suggested that GON4L is a transcriptional regulator that coordinates cell division with differentiation, but its role in B cell development is unknown. To understand the function of GON4L, we characterized B cell differentiation, cell cycle control, and mitotic gene expression in GON4L-deficient B cell progenitors from Justy mice. We found that these cells established key aspects of the transcription factor network that guides B cell development and proliferation and rearranged the IgH gene locus. However, despite intact IL-7 signaling, GON4L-deficient pro-B cell stage precursors failed to undergo a characteristic IL-7–dependent proliferative burst. These cells also failed to upregulate genes required for mitotic division, including those encoding the G1/S cyclin D3 and E2F transcription factors and their targets. Additionally, GON4L-deficient B cell progenitors displayed defects in DNA synthesis and passage through the G1/S transition, contained fragmented DNA, and underwent apoptosis. These phenotypes were not suppressed by transgenic expression of prosurvival factors. However, transgenic expression of cyclin D3 or other regulators of the G1/S transition restored pro-B cell development from Justy progenitor cells, suggesting that GON4L acts at the beginning of the cell cycle. Together, our findings indicate that GON4L is essential for cell cycle progression and division during the early stages of B cell development.
Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia
Authors: Singh Shashi P. , Chand Hitendra S. , Langley Raymond J. , Mishra Neerad , Barrett Ted , Rudolph Karin , Tellez Carmen , Filipczak Piotr T. , Belinsky Steve , Saeed Ali I. , Sheybani Aryaz , Exil Vernat , Agarwal Hemant , Sidhaye Venkataramana K. , Sussan Thomas , Biswal Shyam , Sopori Mohan 
Published: April 2017

Abstract
Embryonic development is highly sensitive to xenobiotic toxicity and in utero exposure to environmental toxins affects physiological responses of the progeny. In the United States, the prevalence of allergic asthma (AA) is inexplicably rising and in utero exposure to cigarette smoke increases the risk of AA and bronchopulmonary dysplasia (BPD) in children and animal models. We reported that gestational exposure to sidestream cigarette smoke (SS), or secondhand smoke, promoted nicotinic acetylcholine receptor–dependent exacerbation of AA and BPD in mice. Recently, perinatal nicotine injections in rats were reported to induce peroxisome proliferator-activated receptor γ–dependent transgenerational transmission of asthma. Herein, we show that first generation and second generation progeny from gestationally SS-exposed mice exhibit exacerbated AA and BPD that is not dependent on the decrease in peroxisome proliferator-activated receptor γ levels. Lungs from these mice show strong eosinophilic infiltration, excessive Th2 polarization, marked airway hyperresponsiveness, alveolar simplification, decreased lung compliance, and decreased lung angiogenesis. At the molecular level, these changes are associated with increased RUNX3 expression, alveolar cell apoptosis, and the antiangiogenic factor GAX, and decreased expression of HIF-1α and proangiogenic factors NF-κB and VEGFR2 in the 7-d first generation and second generation lungs. Moreover, the lungs from these mice exhibit lower levels of microRNA (miR)-130a and increased levels of miR-16 and miR-221. These miRs regulate HIF-1α–regulated apoptotic, angiogenic, and immune pathways. Thus the intergenerational effects of gestational SS involve epigenetic regulation of HIF-1α through specific miRs contributing to increased incidence of AA and BPD in the progenies.
Impact of LUCC on streamflow based on the SWAT model over the Wei River basin on the Loess Plateau in China
Authors: Wang Hong , Sun Fubao , Xia Jun , Liu Wenbin 
Published: April 2017

Abstract. Under the Grain for Green Project in China, vegetation recovery construction has been widely implemented on the Loess Plateau for the purpose of soil and water conservation. Now it is becoming controversial whether the recovery construction involving vegetation, particularly forest, is reducing the streamflow in the rivers of the Yellow River basin. In this study, we chose the Wei River, the largest branch of the Yellow River, with revegetated construction area as the study area. To do that, we apply the widely used Soil and Water Assessment Tool (SWAT) model for the upper and middle reaches of the Wei River basin. The SWAT model was forced with daily observed meteorological forcings (1960–2009) calibrated against daily streamflow for 1960–1969, validated for the period of 1970–1979, and used for analysis for 1980–2009. To investigate the impact of LUCC (land use and land cover change) on the streamflow, we firstly use two observed land use maps from 1980 and 2005 that are based on national land survey statistics merged with satellite observations. We found that the mean streamflow generated by using the 2005 land use map decreased in comparison with that using the 1980 one, with the same meteorological forcings. Of particular interest here is that the streamflow decreased on agricultural land but increased in forest areas. More specifically, the surface runoff, soil flow, and baseflow all decreased on agricultural land, while the soil flow and baseflow of forest areas increased. To investigate that, we then designed five scenarios: (S1) the present land use (1980) and (S2) 10 %, (S3) 20 %, (S4) 40 %, and (S5) 100 % of agricultural land that was converted into mixed forest. We found that the streamflow consistently increased with agricultural land converted into forest by about 7.4 mm per 10 %. Our modeling results suggest that forest recovery construction has a positive impact on both soil flow and baseflow by compensating for reduced surface runoff, which leads to a slight increase in the streamflow in the Wei River with the mixed landscapes on the Loess Plateau that include earth–rock mountain area.
Internally-headed relative clauses in sign languages
Authors: Wilbur Ronnie 
Published: April 2017

This chapter considers relative clause data from sign languages in light of their variation with respect to basic word order, nonmanual marking, and presence/absence of internally-headed and externally-headed relative clauses. Syntactically, a double merge cartographic model (Cinque 2005a; b), following Brunelli (2011), is adopted. The differences across sign languages are suggested to result from differences in raising requirements with respect to the relative clauses themselves and with respect to their heads, rather than basic word order, use of complementizers, relative pronouns, or nominalizers, or (type of) nonmanual marking. Typologically, it is noted that several of the SVO SLs have IHRCs, that at least one SOV SL does not have IHRCs, and that three of the SLs have both internally-headed (IHRCs) and externally-headed (EHRCs) relative clauses.This article is part of the special collection: Internally-headed Relative Clauses
Middle School Students’ Perceptions of Bullying
Authors: Rawlings Jared R. 
Published: April 2017

Abstract
This descriptive study explored middle school band students’ (N = 291) perceptions of bullying behavior. Research questions were designed to generate data regarding the frequency of physical, verbal, and socially aggressive acts self-reported by middle school students enrolled in the band class while in the band classroom, during band-related activities, as well as within the school setting. Using a researcher-modified version of Parada’s (2000) Adolescent Peer Relations Instrument (Cronbach’s alpha = .95 Perpetrator Scale / .95 Victimization Scale) with a response rate of 88%, adolescents in 6th–8th grade were asked to report the frequency of aggressive behaviors. Participants reported experiencing peer victimization more frequently outside of the band classroom than inside the band classroom. Male participants reported slightly higher frequencies of physical victimization than females and Minoritized band students reported slightly higher frequencies of social aggression than White band students. Results suggest that band students’ experiences with bullying behaviors differ depending on biological sex and self-reported race. Suggestions for future research and implications for the profession are discussed.
Vulnerable Experiences in Music Education: Possibilities and Problems for Growth and Connectivity
Authors: Richerme Lauren Kapalka 
Published: April 2017

Abstract
Despite the pervasive potential for teachers and students to experience vulnerability during musically educative endeavors, vulnerability remains largely absent from music education philosophy and discourse. The purpose of this philosophical inquiry is to examine and extend contemporary vulnerability literature and to consider how music educators and students might interface with vulnerable experiences. Vulnerable experiences involve uncertainty, risk, and emotional exposure. The destabilizing of one’s current self-conception that enables personal exploration and development often involves vulnerable experiences. Yet, without any limits, including considering particularly vulnerable individuals, such experiences may inhibit teachers’ and students’ growth. Alternatively, in instances when others meet one’s emotionally exposed musical endeavors with acceptance, vulnerable experiences can facilitate the formation of interpersonal connections as well as foster the development of communities based on shared self-loss. This connectivity, however, can have detrimental consequences if it becomes the primary purpose of music education or if it leads to group solidarity that inhibits critical thinking. While music educators and students might welcome vulnerable experiences into their practices and facilitate spaces in which they can explore them, student input and considerations of autonomy might guide critical deliberations regarding their possible drawbacks and limits.
À qui appartient-il de déterminer les modes d’intervention auprès des personnes intersexuées ?
Authors: Charlebois Janik Bastien 
Published: April 2017

Les personnes intersex(ué)es sont au coeur de tensions dans l’orientation des pratiques médicales sur leur corps et la détermination de leur « propre bien ». La volonté d’autodétermination relayée par les acteurs sociaux politisés et les critiques qu’ils formulent à l’endroit des médecins se heurtent au déficit de crédibilité que celle-ci leur accorde. En isolant certains des motifs les plus solides du maintien de la primauté médicale sur l’orientation des pratiques, nous relevons les arguments développés par la communauté intersexe pour y répondre. Cette réflexion est menée à partir des perspectives philosophiques de Young sur l’autodétermination et du concept d’injustice épistémique de Fricker.
Vingt ans d’intervention de démystification de l’homosexualité et de la bisexualité dans les écoles
Authors: Vallerand Olivier , Charbonneau Amélie , Lavoie Kévin , Houzeau Marie 
Published: April 2017

Depuis plus de 20 ans, le Groupe de recherche et d’intervention sociale (GRIS) de Montréal réalise des interventions de démystification de l’homosexualité et de la bisexualité dans des écoles de Montréal et des régions environnantes. Son 20e anniversaire est une occasion de procéder à un bilan et à une réflexion critique sur ses activités. Trois enjeux sont discutés dans cet article, soit le rôle du discours religieux dans la réception des interventions, l’importance de la déconstruction des rôles de genre dans la lutte contre l’homophobie, la lesbophobie et la biphobie, ainsi que le tabou entourant la sexualité.
Evolutionary analysis of vision genes identifies potential drivers of visual differences between giraffe and okapi
Authors: Ishengoma Edson , Agaba Morris , Cavener Douglas R. 
Published: April 2017

BackgroundThe capacity of visually oriented species to perceive and respond to visual signal is integral to their evolutionary success. Giraffes are closely related to okapi, but the two species have broad range of phenotypic differences including their visual capacities. Vision studies rank giraffe’s visual acuity higher than all other artiodactyls despite sharing similar vision ecological determinants with many of them. The extent to which the giraffe’s unique visual capacity and its difference with okapi is reflected by changes in their vision genes is not understood.MethodsThe recent availability of giraffe and okapi genomes provided opportunity to identify giraffe and okapi vision genes. Multiple strategies were employed to identify thirty-six candidate mammalian vision genes in giraffe and okapi genomes. Quantification of selection pressure was performed by a combination of branch-site tests of positive selection and clade models of selection divergence through comparing giraffe and okapi vision genes and orthologous sequences from other mammals.ResultsSignatures of selection were identified in key genes that could potentially underlie giraffe and okapi visual adaptations. Importantly, some genes that contribute to optical transparency of the eye and those that are critical in light signaling pathway were found to show signatures of adaptive evolution or selection divergence. Comparison between giraffe and other ruminants identifies significant selection divergence inCRYAAandOPN1LW. Significant selection divergence was identified inSAGwhile positive selection was detected inLUMwhen okapi is compared with ruminants and other mammals. Sequence analysis ofOPN1LWshowed that at least one of the sites known to affect spectral sensitivity of the red pigment is uniquely divergent between giraffe and other ruminants.DiscussionBy taking a systemic approach to gene function in vision, the results provide the first molecular clues associated with giraffe and okapi vision adaptations. At least some of the genes that exhibit signature of selection may reflect adaptive response to differences in giraffe and okapi habitat. We hypothesize that requirement for long distance vision associated with predation and communication with conspecifics likely played an important role in the adaptive pressure on giraffe vision genes.
Seasonally distinct taxonomic and functional shifts in macroinvertebrate communities following dam removal
Authors: Sullivan S. Mažeika P. , Manning David W.P. 
Published: April 2017

Dam removal is an increasingly popular restoration tool, but our understanding of ecological responses to dam removal over time is still in the early stages. We quantified seasonal benthic macroinvertebrate density, taxonomic composition, and functional traits for three years after lowhead dam removal in three reaches of the Olentangy River (Ohio, USA): two upstream of former dam (one restored, one unrestored), and one downstream of former dam. Macroinvertebrate community density, generic richness, and Shannon–Wiener diversity decreased between ∼9 and ∼15 months after dam removal; all three variables consistently increased thereafter. These threshold responses were dependent on reach location: density and richness increased ∼15 months after removal in upstream reaches versus ∼19 months downstream of the former dam. Initial macroinvertebrate density declines were likely related to seasonality or life-history characteristics, but density increased up to 2.27× from year to year in three out of four seasons (late autumn, early spring, summer) across all reaches. Macroinvertebrate community composition was similar among the three reaches, but differed seasonally based on non-metric multidimensional scaling (NMDS) and analysis of similarity (ANOSIM). Seasonal differences among communities tended to decrease after dam removal. We detected community-wide shifts in functional traits such as multivoltinism, depositional habitat use, burrowing, and collector-gatherer feeding mode. We observed that these traits were expressed most strongly with Chironomidae, which was the most abundant family. Our results suggest that seasonal environmental conditions can play a role in the response and recovery of macroinvertebrate communities—often used to monitor ecosystem condition—following dam removal. In particular, macroinvertebrate density and diversity can show recovery after dam removal, especially in seasons when macroinvertebrate density is typically lowest, with concomitant changes to functional trait abundance. Thus, we recommend scientists and managers consider responses to dam removal throughout the year. Further, similar density, generic richness, and functional traits among reaches suggest that channel restoration after dam removal may initially have equivocal effects on invertebrate communities.
O COMPROMISSO EDUCACIONAL DA UNIÃO, ESTADOS E MUNICÍPIOS: COLABORAÇÃO, SUBORDINAÇÃO OU OMISSÃO?
Authors: Davies Nicholas 
Published: April 2017

<p class="MsoNormal"><span style="font-size: 11.0pt; line-height: 150%; font-family: ";Garamond";,";serif";; mso-fareast-font-family: ";Times New Roman";; mso-bidi-font-family: Arial; mso-fareast-language: PT-BR;">O artigo examina o poder, a atuação e a responsabilidade constitucional e legal dos governos federal, estaduais e municipais na educação básica. Mostra a fragilidade da colaboração entre eles, em virtude da preponderância do governo federal na formulação da legislação e responsabilização dos entes subnacionais na execução e financiamento das políticas educacionais. Entretanto, os governos estaduais também são responsáveis. Arrecadam muito mais impostos do que os municípios, porém reduziram drasticamente as matrículas no ensino fundamental de 1997 a 2012. Da mesma forma, os municípios são responsáveis, pois milhares deles diminuíram suas matrículas na educação básica de 2006 a 2012. </span></p>
Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells
Authors: Giovannini Sara , Li Yanan , Pecorari Rosalba , Fierro Claudia , Fiorilli Claudia , Corigliano Federica , Moriconi Valeria , Zhou Ji , De Antoni Anna , Smirnov Artem , Rinalducci Sara , Timperio Anna Maria , Agostini Massimiliano , Zhang Jinping , Shi Yufang , Candi Eleonora , Melino Gerry , Bernassola Francesca 
Published: October 2024

The HECT‐type E3 ubiquitin WWP1 (also known as NEDD4‐like E3 ubiquitin‐protein ligase WWP1) acts as an oncogenic factor in acute myeloid leukemia (AML) cells. WWP1 overexpression in AML confers a proliferative advantage to leukemic blasts (abnormal immature white blood cells) and counteracts apoptotic cell death and differentiation. In an effort to elucidate the molecular basis of WWP1 oncogenic activities, we identified WWP1 as a previously unknown negative regulator of thioredoxin‐interacting protein (TXNIP)‐mediated reactive oxygen species (ROS) production in AML cells. TXNIP inhibits the disulfide reductase enzymatic activity of thioredoxin (Trx), impairing its antioxidant function and, ultimately, leading to the disruption of cellular redox homeostasis. In addition, TXNIP restricts cell growth and survival by blocking glucose uptake and metabolism. Here, we found that WWP1 directly interacts with TXNIP, thus promoting its ubiquitin‐dependent proteasomal proteolysis. As a result, accumulation of TXNIP in response to WWP1 inactivation in AML blasts reduces Trx activity and increases ROS production, hence inducing cellular oxidative stress. Increased ROS generation in WWP1‐depleted cells culminates in DNA strand breaks and subsequent apoptosis. Coherently with TXNIP stabilization following WWP1 inactivation, we also observed an impairment of both glucose up‐take and consumption. Hence, a contribution to the increased cell death observed in WWP1‐depleted cells also possibly arises from the attenuation of glucose up‐take and glycolytic flux resulting from TXNIP accumulation. Future studies are needed to establish whether TXNIP‐dependent deregulation of redox homeostasis in WWP1‐overexpressing blasts may affect the response of leukemic cells to chemotherapeutic drugs.
Dual‐Functional Ca‐Ion‐Doped Layered δ‐MnO2 Cathode for High‐Performance Aqueous Zinc‐Ion Batteries
Authors: Xie Dongmei , Wang Yan , Tian Leiwu , Huang Haiji , Sun Jianyang , Kim Dong‐Won , Zhao Jiachang , Mao Jianfeng 
Published: October 2024

AbstractAqueous zinc‐ion batteries (ZIBs) have gained significant attention owing to their high energy densities, low costs, and enhanced safety profiles. However, the development of suitable host materials (i.e., cathodes) with high capacity, structural stability, and rate performance remains challenging. Herein, a nanoflower‐like Ca0.10MnO2·0.61H2O (CaMnO) is successfully synthesized as a high‐performance cathode material for ZIBs using a simplified one‐step hydrothermal method. The unique nanoflower‐like 3D porous structure provides a continuous conductive path and abundant adsorption sites for Zn2+ ions and mitigates aggregation during long‐term cycling processes. In addition, doping Ca2+ ions into the interlayer of MnO2 has a dual functional effect: 1) it acts as a pillar to broaden the interlayer spacing and enhance the crystal structure stability, and 2) it induces the formation of oxygen vacancies to enhance the reaction kinetics and increase the reversible capacity. Therefore, the CaMnO cathode exhibits a high specific capacity of 289 mAh g−1, with excellent capacity retention (90%) over 750 cycles at a high current rate of 1.5 A g−1. This study provides a new perspective on the development of advanced cathode materials for ZIBs.