bluuebunny/crossref_metadata_2025_split huggingface dataset:
Re-resection of remnant Caroli syndrome six years after the first resection (case report)
Authors: Zidan Ahmed , Bauschke Astride , Scheuerlein Hubert , Settmacher Utz , Rauchfuss Falk 
Published: April 2016

ABSTRACT

Introduction:
Caroli syndrome is characterized as multiple cystic or saccular dilatations of intrahepatic bile ducts (Caroli disease) and congenital hepatic fibrosis. Diagnosis depends on histological features and imaging, which shows communications between the sacculi and bile ducts.

Presentation of a case:
In our case, the patient had segments II/III liver resection six years ago for Caroli syndrome. A follow-up CT after four months of the operation revealed remnant cysts in segment IV, which needed another surgical intervention to resect the remnant cysts and segment IV after six years from the first operation.

Disscussion:
In our case, we were surprised that patient has remnant of the primary benign disease in the follow-up CT after only four months of the previous operation. This remnant continued to increase in size with recurrent attacks of cholangitis until liver abscess developed and required another surgical intervention.

Conclusion:
Imaging is essential in planning the operative treatment to detect the extent of the Caroli disease and define the extent of resection. Any residual disease due to inappropriate imaging planning may cost the patient another cycle of suffering and may need another surgical intervention as in our case. We recommend using intraoperative ultrasound for accurate determination of the line of resection.

Highlights
O‐GlcNAcylation: A regulator of tau pathology and neurodegeneration
Authors: Gong Cheng‐Xin , Liu Fei , Iqbal Khalid 
Published: April 2016

AbstractO‐GlcNAcylation is the posttranslational modification of intracellular proteins by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc). The discovery of O‐GlcNAc modification of tau and its impact on tau phosphorylation has attracted recent research interest in O‐GlcNAc studies in the Alzheimer's disease (AD) field. Modification of proteins by O‐GlcNAc occurs extensively in the brain. The expressions and activities of the enzymes catalyzing O‐GlcNAc cycling are several‐fold higher in the brain than in the peripheral tissues. The O‐GlcNAcylation levels of brain proteins including tau are decreased in AD brain, probably due to decreased brain glucose metabolism. The reduction of brain O‐GlcNAcylation appears to mediate the molecular mechanism by which decreased brain glucose metabolism contributes to neurodegeneration. Studies on mouse models of tauopathies suggest a neuroprotective role of pharmacological elevation of brain O‐GlcNAc, which could potentially be a promising approach for treating AD and other neurodegenerative diseases.
Idiopathic megacolon in a teenager treated by laparoscopic rectosigmoidectomy
Authors: Sodero Carlos Eduardo Oliveira , da Silva Emerson Abdulmassih Wood , de Castro Rezende Júnior Dirceu , Tiveron Gustavo Roberto Carvalho , Zago Aurélio Fabiano Ribeiro , de Oliveira Rafael Andrade , Souza Bernardo Rosae e , Pelegrinelli Luciano Ricardo 
Published: April 2016

AbstractChronic constipation in children and adolescents is relatively common and a reason for consultation with pediatricians and proctologists. Most cases respond to medical treatment. Advanced cases of megacolon and megarectum can be treated surgically by Duhamel technique.This case report describes a 15-year-old patient with chronic intestinal constipation refractory to clinical treatment associated with megacolon and megarectum, which was surgically treated.
A clearer spotlight on spotlight: Understanding, conducting and reporting
Authors: Krishna Aradhna 
Published: April 2016

AbstractThere has been a remarkable increase in the use of spotlight analysis to examine any interactive effect between an independent variable and a continuous moderator. Most of the spotlight analyses have been conducted at one standard deviation above and below the mean value of the moderator, even when alternate methods are more appropriate. Additionally, many spotlight analyses are not conducted correctly. More importantly, results for spotlight analyses are reported in a manner that makes it virtually impossible for mistakes to be detected. This article focuses on “understanding,” “conducting,” and “reporting” spotlight analyses. By posing questions for the reader, it highlights some common mistakes made when doing spotlight analysis and explains why confusion often arises. Then it provides an easy to understand way to do spotlight analysis for some popular contexts. Alternatives to spotlight analysis are also briefly discussed. Finally, it suggests how to report results for spotlight analysis and for the alternatives. Pointing out recurrent mistakes should prevent perpetuation of misleading practices. Similarly, reporting essential details of the analyses should prevent mistakes from going undetected.
Temporal sinus node modification by high‐dose continuous intravenous administration of landiolol in a patient with persistent inappropriate sinus tachycardia
Authors: Hori Yuichi , Nakahara Shiro , Anjo Naofumi , Sakai Yoshihiko , Taguchi Isao 
Published: April 2016

AbstractA 20‐year‐old woman underwent an electrophysiological study for drug‐resistant persistent inappropriate sinus tachycardia (IST). Use of a high‐dose continuous intravenous administration of landiolol, a short‐acting beta‐adrenoreceptor blocker, made the patient's heart rate suddenly drop with a slight change in the P‐wave morphology. Three‐dimensional right atrial (RA) activation mapping revealed that the earliest activation site moved 8 mm to a lower anterior site around the high lateral RA. Radiofrequency energy applied to the earliest activation site during tachycardia was successful. A temporal sinus node modification with landiolol administration was useful for mapping and for safe catheter ablation of IST.
Successful cryoballoon pulmonary vein isolation in a patient with situs inversus and dextrocardia
Authors: Yoshiga Yasuhiro , Shimizu Akihiko , Ueyama Takeshi , Ono Makoto , Fumimoto Tomoko , Ishiguchi Hironori , Yano Masafumi 
Published: April 2016

AbstractA 79‐year‐old man with situs inversus and dextrocardia underwent catheter ablation of symptomatic paroxysmal atrial fibrillation. Pulmonary vein isolation (PVI), using second‐generation cryoballoon under Ensite NavX system guidance, was performed successfully in a reverse manner, which required short procedure and fluoroscopy times, as required in a PVI performed on a normal heart without any complications. Cryoballoon‐based PVI under Ensite NavX guidance was feasible and safe to achieve a favorable outcome in this patient with abnormal anatomy.
Pharmacokinetic study of eplerenone in rats after long‐term coadministration with buckwheat tea
Authors: Zou Liang , Jia Kun , Li Rui , Wang Ping , Lin Jun‐Zhi , Chen Hui‐Juan , Zhao Gang , Peng Lian‐Xin 
Published: April 2016

AbstractThe aim of this study was to investigate the effect of long‐term intake of Tartary buckwheat tea on the pharmacokinetics (PK) of eplerenone in rats. A validated high‐performance liquid chromatography‐mass spectrometry (HPLC‐MS) method was established to determine the eplerenone in plasma, and the portal vein absorption model was applied to conduct the pharmacokinetic study. Two groups of animals—buckwheat tea group and control group—were involved in this study. Plasma samples were obtained at different time points after administration, and were separated on Shimadzu HPLC‐MS 2020 instruments. The method showed good linearity (r = 0.9988) over a wide dynamic range (0.20–50 μg/mL). Within‐ and between‐batch precisions ranged from 2.13% to 7.90%. The extraction recovery rates ranged from 91.96% to 94.96%. The data showed that in the Tartarian buckwheat group the area under the curve and maximum concentration of eplerenone were reduced compared with those of the blank group (p < 0.01), but the time to reach peak concentrations of eplerenone (p < 0.01) was prolonged. The results suggested that long‐term consumption of Tartary buckwheat tea might induce the activities of the hepatic drug metabolizing enzyme, which can accelerate the metabolism of eplerenone. According to the results, the dosage of eplerenone should be adjusted in hypertension treatment trials when administered with Tartary buckwheat or Tartary buckwheat‐containing dietary supplements to avoid potential drug interactions.
Ischemia‐modified albumin levels in the prediction of acute critical neurological findings in carbon monoxide poisoning
Authors: Daş Murat , Çevik Yunsur , Erel Özcan , Çorbacioğlu Şeref Kerem 
Published: April 2016

AbstractThe aim of the study was to determine whether serum ischemia‐modified albumin (IMA) levels in patients with carbon monoxide (CO) poisoning were higher compared with a control group of healthy volunteers. In addition, the study sought to determine if there was a correlation between serum IMA levels and carboxyhemoglobin (COHB) levels and other critical neurological findings (CNFs). In this prospective study, the IMA levels of 100 patients with CO poisoning and 50 control individuals were compared. In addition, the IMA and COHB levels were analyzed according to absence or presence CNFs in patients with CO poisoning. The levels of IMA (mg/dL) on admittance, and during the 1st hour and 3rd hour, in patients with CO poisoning (49.90 ± 35.43, 30.21 ± 14.81, and 21.87 ± 6.03) were significantly higher, compared with the control individuals (17.30 ± 2.88). The levels of IMA in the 6th hour were not higher compared with control individuals. The levels of IMA on admittance, and during the 1st hour, 3rd hour, and 6th hour, and COHB (%) levels in patients who had CNFs were higher compared with IMA levels and COHB levels in patients who had no CNFs (p < 0.001). However, when the multivariate model was created, it was observed that IMA level on admittance was a poor indicator for prediction of CNFs (odds ratio = 1.05; 95% confidence interval, 1.01–1.08). We therefore concluded that serum IMA levels could be helpful in the diagnosis of CO poisoning. However, we believe that IMA levels cannot be used to predict which patients will develop CNFs due to CO poisoning.
Clinical experiences of dynamic stabilizers: Dynesys and Dynesys top loading system for lumbar spine degenerative disease
Authors: Hsieh Cheng‐Ta , Chang Chih‐Ju , Su I‐Chang , Lin Li‐Ying 
Published: April 2016

AbstractDynesys (Dynamic Neutralization System) was designed to overcome the shortcomings of fusion. The Dynesys top loading (DTL) system is a new alternative Dynesys system that can be applied via a minimally invasive procedure. This study aimed to ascertain whether DTL is a suitable device for motion preservation and prevention of instability, and to compare the clinical and radiological outcomes between DTL and Dynesys. In this study, 12 patients were treated with Dynesys and 21 patients were treated with DTL. Back and leg pain were evaluated using the visual analog scale. The Oswestry Disability Index was used to evaluate the patients' function. Range of motion (ROM) at the operative level and for the whole lumbar spine was measured pre‐ and postoperatively. The length of wound, blood loss, length of hospital stay, and operation duration were also compared. All patients were followed up for 12–76 months. Scores on the visual analog scale and Oswestry Disability Index were significantly improved postoperatively. The median ROM of the whole spine and index level ROM in all patients showed 12.5% and 79.6% loss, respectively. The DTL group exhibited significantly better results in terms of blood loss, wound length, and operation duration, in addition to early ambulation. In conclusion, Dynesys and DTL are semirigid fixation systems that can significantly improve clinical symptoms and signs. Our results suggested that DTL was better than Dynesys as a result of it being a minimally invasive procedure. However, further study with large sample sizes and longer follow‐up durations is required to validate the effects of these dynamic stabilizers.
Cycling Injuries in Southwest Colorado: A Comparison of Road vs Trail Riding Injury Patterns
Authors: Kotlyar Simon 
Published: April 2016

Objective To describe the epidemiology of injuries sustained in cyclists and compare the injury patterns in road vs trail biking accidents. Methods A retrospective chart review was performed of injured road and trail cyclists presenting to a rural mountain resort–based medical center during a 3-year study period. Results Of 304 patients, 70% were male, with 67% sustaining trail injuries and 33% sustaining road cycling injuries. There was a bimodal age distribution. Prehospital care was activated in 16% of patients. The most common injuries were lacerations and abrasions (64%), upper extremity fractures (26%), head injuries (9%), and thoracic trauma (6%). Head injury was more common in road- vs trail-related trauma (16% vs 6%; P = .005), whereas thoracic injury was more common in trail riders (7% vs 2%; P = .053). Head injury and lower extremit y fracture were the most common reasons for patient transfer. Patients with head injuries who did not use a helmet were more likely to require transfer to a neurosurgical unit (38% vs 17%; P = .296); however, this difference did not meet statistical significance. Conclusions Lacerations and abrasions are the most common injuries sustained in cycling. Quantifying the role of protective extremity gear in reducing these injury patterns may be of interest for future studies. Protective helmet use may be important in reducing morbidity from cycling-related head trauma; however, more data are needed. Prehospital care providers responding to the injured trail cyclist should be equipped to manage laceration, fracture, head injury, and thoracic trauma in the field.
APPAGATO: an APproximate PArallel and stochastic GrAph querying TOol for biological networks
Authors: Bonnici Vincenzo , Busato Federico , Micale Giovanni , Bombieri Nicola , Pulvirenti Alfredo , Giugno Rosalba 
Published: April 2016

Abstract

Motivation
Biological network querying is a problem requiring a considerable computational effort to be solved. Given a target and a query network, it aims to find occurrences of the query in the target by considering topological and node similarities (i.e. mismatches between nodes, edges, or node labels). Querying tools that deal with similarities are crucial in biological network analysis because they provide meaningful results also in case of noisy data. In addition, as the size of available networks increases steadily, existing algorithms and tools are becoming unsuitable. This is rising new challenges for the design of more efficient and accurate solutions.

Results
This paper presents APPAGATO, a stochastic and parallel algorithm to find approximate occurrences of a query network in biological networks. APPAGATO handles node, edge and node label mismatches. Thanks to its randomic and parallel nature, it applies to large networks and, compared with existing tools, it provides higher performance as well as statistically significant more accurate results. Tests have been performed on protein–protein interaction networks annotated with synthetic and real gene ontology terms. Case studies have been done by querying protein complexes among different species and tissues.

Availability and implementation
APPAGATO has been developed on top of CUDA-C ++ Toolkit 7.0 framework. The software is available online http://profs.sci.univr.it/∼bombieri/APPAGATO.

Supplementary information
Supplementary data are available at Bioinformatics online.
XLinkDB 2.0: integrated, large-scale structural analysis of protein crosslinking data
Authors: Schweppe Devin K. , Zheng Chunxiang , Chavez Juan D. , Navare Arti T. , Wu Xia , Eng Jimmy K. , Bruce James E. 
Published: April 2016

Abstract
Motivation: Large-scale chemical cross-linking with mass spectrometry (XL-MS) analyses are quickly becoming a powerful means for high-throughput determination of protein structural information and protein–protein interactions. Recent studies have garnered thousands of cross-linked interactions, yet the field lacks an effective tool to compile experimental data or access the network and structural knowledge for these large scale analyses. We present XLinkDB 2.0 which integrates tools for network analysis, Protein Databank queries, modeling of predicted protein structures and modeling of docked protein structures. The novel, integrated approach of XLinkDB 2.0 enables the holistic analysis of XL-MS protein interaction data without limitation to the cross-linker or analytical system used for the analysis.
Availability and Implementation: XLinkDB 2.0 can be found here, including documentation and help: http://xlinkdb.gs.washington.edu/ .
Contact : jimbruce@uw.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
Value of Baseline Cardiovascular Mechanics in Predicting Exercise Training Success
Authors: Aslanger Emre , Assous Benjamin , Bihry Nicolas , Beauvais Florence , Logeart Damien , Cohen-Solal Alain 
Published: April 2016

PURPOSE:
Despite being repeatedly shown that exercise training (ET) increases exercise capacity and decreases mortality in many cardiac conditions, not all patients enjoy the benefits of ET programs. We hypothesized that baseline cardiovascular mechanic properties, including cardiac systolic and diastolic functions, arterial mechanics and ventriculoarterial interaction, may have a role in predicting response to ET.

METHODS:
Full left ventricular pressure-volume loops were constructed and arterial mechanics were evaluated using echocardiographic and tonometric measurements. A cardiopulmonary exercise (CPX) test was performed before and after the ET program.

RESULTS:
Sixty of the 75 patients with coronary artery disease or heart failure diagnoses completed the study. All of the CPX parameters showed a significant improvement with ET. The change in oxygen uptake correlated only with arterial parameters, such as compliance (r = 0.399, P = .002), end-systolic arterial elastance (r = −0.293, P = .02), aortic pulse pressure (r = −0.302, P = .02), and brachial pulse pressure (r = −0.312, P = .01). Receiver-operating characteristics analysis demonstrated that baseline arterial compliance and brachial pulse pressure predicted a significantly positive ET result with reasonable sensitivity and specificity.

CONCLUSIONS:
Patients with a more compliant arterial system improved their exercise capacity more with ET. Evaluation of baseline arterial compliance may facilitate proper patient selection and may define patients who need optimizing measures for the arterial system before commencing ET. Even a simple blood pressure measurement may give clues in this regard.
A Simplified (Screening) Approach to Check the Calibration Status of the Goldmann Applanation Tonometer
Authors: Choudhari Nikhil S. , Ramavath Suresh , Rekha Gunturu , Rao Aparna , Rao Harsha L. , Senthil Sirisha , Garudadri Chandra Sekhar 
Published: April 2016

Background:
To investigate whether a lower-end calibration error check alone can identify a Goldmann applanation tonometer (GAT) with acceptable calibration error as per Asia-Pacific Glaucoma Society (APGS) and World Glaucoma Association (WGA) guidelines.

Methods:
This was a multicentric prospective study in a tertiary eye-care institutional setting. Seventy-six slit-lamp–mounted Haag-Streit GATs (Model AT 900 C/M) were included in the study. All GATs were checked for calibration error at 0, 20, and 60 mm Hg testing levels as recommended by the manufacturer. The ability of 2 screening criteria (calibration error within ±1 or ±2 mm Hg, respectively, at the 0 mm Hg testing level without using the calibration error check weight bar) to identify a tonometer within acceptable calibration limits defined by APGS (calibration error within ±2, ±3, and ±4 mm Hg at 0, 20, and 60 mm Hg testing levels, respectively) and WGA (calibration error within ±1 mm Hg at all testing levels) was determined.

Main Outcome Measure:
The negative likelihood ratio of the screening criteria

Results:
Five (6.6%) and 42 (55%) GATs were outside of the APGS and the WGA calibration limits, respectively. Negative likelihood ratios of the first and the second screening criteria at the APGS definition of calibration error tolerance were 0.11 and 0.25, respectively, and at that of the WGA definition of calibration error tolerance were 0.38 and 0.90, respectively.

Conclusions:
The screening criteria of calibration error within ±1 mm Hg at the 0 mm Hg testing level seem to be clinically useful to detect GAT with an acceptable calibration error as per the APGS guideline.
The Decreasing Prevalence of Severe Villous Atrophy in Dermatitis Herpetiformis
Authors: Mansikka Eriika , Hervonen Kaisa , Salmi Teea T. , Kautiainen Hannu , Kaukinen Katri , Collin Pekka , Reunala Timo 
Published: April 2016

Goals:
We analyzed from our prospectively collected series of patients with dermatitis herpetiformis (DH) whether small-bowel histologic findings are changing and how serum tissue transglutaminase (TG2) IgA antibodies correlate to mucosal damage.

Background:
DH is an extraintestinal manifestation of celiac disease presenting with itchy blistering rash and pathognomonic IgA deposits in the skin. Prominent gastrointestinal symptoms are rare, and small-bowel findings range from severe villous atrophy (SVA) and partial villous atrophy (PVA) to normal mucosa with inflammatory changes.

Methods:
The cohort included 393 patients (214 male and 179 female) with DH having small-bowel biopsies performed at Tampere University Hospital since 1970. The small-bowel findings were calculated in the three 15-year periods, and in the last period they were correlated with serum IgA class TG2 antibody levels measured by enzyme-linked immunosorbent assay.

Results:
The prevalence of SVA decreased significantly (P=0.032), from 42% in the first study period to 29% in the last study period. A concomitant increase was seen in PVA, from 33% to 41%, and normal villous architecture, from 25% to 30%. The patients with SVA (P<0.001) and PVA (P=0.046) had significantly higher TG2 antibody levels than those with normal villous architecture.

Conclusions:
This long-term study in patients with DH disclosed a significant decrease in the occurrence of SVA. Serum IgA TG2 antibody levels correlated to damage in the small bowel. The trend toward milder small-bowel histology in DH suggests that a similar pattern could occur in the pool of undiagnosed celiac disease from which DH develops.