bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global-scale evaluation of 22 precipitation datasets using gauge observations and hydrological modeling
Authors: Beck Hylke E. , Vergopolan Noemi , Pan Ming , Levizzani Vincenzo , van Dijk Albert I. J. M. , Weedon Graham P. , Brocca Luca , Pappenberger Florian , Huffman George J. , Wood Eric F. 
Published: December 2017

Abstract. We undertook a comprehensive evaluation of 22 gridded (quasi-)global (sub-)daily precipitation (P) datasets for the period 2000–2016. Thirteen non-gauge-corrected P datasets were evaluated using daily P gauge observations from 76 086 gauges worldwide. Another nine gauge-corrected datasets were evaluated using hydrological modeling, by calibrating the HBV conceptual model against streamflow records for each of 9053 small to medium-sized ( <  50 000 km2) catchments worldwide, and comparing the resulting performance. Marked differences in spatio-temporal patterns and accuracy were found among the datasets. Among the uncorrected P datasets, the satellite- and reanalysis-based MSWEP-ng V1.2 and V2.0 datasets generally showed the best temporal correlations with the gauge observations, followed by the reanalyses (ERA-Interim, JRA-55, and NCEP-CFSR) and the satellite- and reanalysis-based CHIRP V2.0 dataset, the estimates based primarily on passive microwave remote sensing of rainfall (CMORPH V1.0, GSMaP V5/6, and TMPA 3B42RT V7) or near-surface soil moisture (SM2RAIN-ASCAT), and finally, estimates based primarily on thermal infrared imagery (GridSat V1.0, PERSIANN, and PERSIANN-CCS). Two of the three reanalyses (ERA-Interim and JRA-55) unexpectedly obtained lower trend errors than the satellite datasets. Among the corrected P datasets, the ones directly incorporating daily gauge data (CPC Unified, and MSWEP V1.2 and V2.0) generally provided the best calibration scores, although the good performance of the fully gauge-based CPC Unified is unlikely to translate to sparsely or ungauged regions. Next best results were obtained with P estimates directly incorporating temporally coarser gauge data (CHIRPS V2.0, GPCP-1DD V1.2, TMPA 3B42 V7, and WFDEI-CRU), which in turn outperformed the one indirectly incorporating gauge data through another multi-source dataset (PERSIANN-CDR V1R1). Our results highlight large differences in estimation accuracy, and hence the importance of P dataset selection in both research and operational applications. The good performance of MSWEP emphasizes that careful data merging can exploit the complementary strengths of gauge-, satellite-, and reanalysis-based P estimates.
Unsettling the (presumed) settled: Contents and Discontents of Contraception in Aotearoa New Zealand
Authors: Appleton N. S. 
Published: December 2017

In January 2017, New Zealand’s medicines and medical devices safety authority, Medsafe, announced in a press release that its Medicines Classification Committee (MCC) had recommended a reclassification of certain oral contraceptives in order for them to be made available over the counter in pharmacies. In A/NZ, a progressive temporal narrative has been established around contraception that begins with the heroic struggle of women at the turn of the 20th Century to get access to contraception and abortion as a way to manage their reproductive lives and progresses to the guaranteed access of contraceptives to women. My intention to interrogate the contemporary contraceptive reality is not a project to undermine the historically important moves women have made here in A/NZ; but, rather, to include new places of analysis including how indigenous communities experienced the same contraceptives moments differently under the gaze of a eugenics project.
Feasibility of arthroscopic autologous chondrocyte implantation in the hip using an injectable hydrogel
Authors: Thier Steffen , Baumann Florian , Weiss Christel , Fickert Stefan 
Published: December 2017

Introduction: In the long term the treatment of articular cartilage defects of the hip has the most direct impact on the postoperative outcome and should diminish degenerative changes caused by different pathologies. The purpose of this prospective feasibility study is to describe technical aspects of arthroscopic, injectable autologous chondrocyte implantation in the hip and to report the short-term outcome. Methods: Full-thickness cartilage defects of 13 patients were treated arthroscopically with an injectable autologous chondrocyte transplantation product (Novocart Inject, Tetec) in a 2-step surgical procedure. Patient-related outcome was assessed with iHOT 33, EQ-5D and Non Arthritic Hip Score at baseline (day before transplantation), after 6 weeks and 3, 6 and 12 months. Results: 13 out of 13 patients (all men) with a mean age of 32.7 ± 6.9 years and an average defect size of 1.9 ± 1.0 cm2 were available for follow-up after a mean of 12 months (range 6-24 months). All defects were located on the acetabulum and 11 were associated with a labral lesion of 2.9 hours size. Femoroacetabular impingement (10 cam, 2 combined, 1 pincer) was the cause of all defects. An overall statistically significant improvement was observed for all assessment scores. Conclusions: In this study we present the feasibility and short-term data of an arthroscopic injectable autologous chondrocyte transplant as a treatment option for full-thickness cartilage defects of the hip. All patient-administered assessment scores demonstrated an increase in activity level, improvement in quality of life and reduction of pain after a 12-month follow-up. Further randomised controlled trails with long-term follow-up and additional morphological assessment are needed.
Patient-reported quality of life and hip function after 2-stage revision of chronic periprosthetic hip joint infection: a cross-sectional study
Authors: Poulsen Ninna R. , Mechlenburg Inger , Søballe Kjeld , Lange Jeppe 
Published: December 2017

Introduction: Very limited information is available regarding patient-reported health-related quality of life (HRQoL) and hip function following treatment for chronic periprosthetic hip joint infection (PJI). Patient-reported outcome measures provide essential information to clinicians of the impact a treatment have on patient’s lives. The purpose of this study was to examine patient reported HRQoL and hip function after a completed re-implantation in a 2-stage revision. Method: 82 patients were identified retrospectively in the National Patient Register. 57 patients were alive and asked to complete the questionnaires EuroQol-5D (EQ-5D) and Oxford Hip Score (OHS) in November 2014. Results were compared to normative population data for EQ-5Dindex. Patients re-infected after a completed 2-stage revision were compared with not re-infected. Results: 45 patients completed the questionnaires. Mean time since re-implantation was 8.2 years (95% CI [confidence interval], 7.7-0.87). The EQ-5D index mean for the 2-stage group was 0.71 (0.64; 0.77) whereas the general population mean is 0.85 (0.84-0.85), p = 0.0004. The 2-stage revision patients scored significantly lower on every EQ-5D dimension. The re-infected group mean EQ-5D index score was significantly lower compared to the not re-infected group, p = 0.003. The EQ-VAS mean score was 58.2 (57.3-68.3) and the mean OHS for the group was 29.2 (25.4-33.0). Conclusions: Patients who undergo 2-stage revision after a PJI have lower scores on HRQoL than the general population. Patients who are re-infected following revision have a lower HRQoL score than patients not re-infected. Future research should focus on optimising patient-reported outcomes after treatment for PJI.
Decline in allogeneic blood transfusion usage in total hip arthroplasty patients: National Inpatient Sample 2009 to 2013
Authors: Gwam Chukwuweike U. , Mistry Jaydev B. , Etcheson Jennifer I. , George Nicole E. , Connors Grayson , Thomas Melbin , Adamu Hephzibah , Patel Nirav G. , Delanois Ronald E. 
Published: December 2017

Introduction: Although total hip arthroplasty (THA) is an effective treatment for end-stage arthritis, it is also associated with substantial blood loss that may require allogeneic blood transfusion. However, these transfusions may increase the risk of certain complications. The purpose of our study is to evaluate: (i) the incidence/trends of allogeneic blood transfusion; (ii) the associated risk factors and adverse events; and (iii) the discharge disposition, length of stay (LOS), and costs for these patients between 2009 and 2013. Methods: The National Inpatient Sample database was used to identify 1,542,366 primary THAs performed between 2009 and 2013. Patients were stratified based on demographics, economic data, hospital characteristics, comorbidities, and whether or not allogeneic transfusion was received. Logistic regression was performed to evaluate the risk factors for transfusion and postoperative complications. Results: From 2009 to 2013, allogeneic transfusions were used in 16.9% of primary THAs, with a declining annual incidence. Except for obesity, all comorbidities were associated with increased likelihood of receiving a transfusion. Allogeneic transfusion patients were more likely to experience surgical site infections or pulmonary complications (p<0.001 for all). These patients were more likely to be discharged to a short-term care facility (p<0.001). Additionally, they had a greater mean LOS (p<0.001) and higher median hospital costs and charges when compared to their non-transfused counterparts. Conclusions: While the observed decline in allogeneic transfusion usage is encouraging, further efforts should focus on preoperative patient optimisation. Given the projected increase in demand for primary THAs, orthopaedic surgeons must be familiar with safe and effective blood conservation protocols.
Development and sensorial acceptance of biofortified cassava snack
Authors: Oliveira Luciana Alves de , Reis Ronielli Cardoso , Santana Hannah Miranda , Santos Vanderlei Da Silva , Carvalho José Luiz Viana de 
Published: December 2017

Cassava is the food base for millions of people in tropical Africa, Latin America and Asia. However, cassava commercial varieties are deficient in vitamin A and the consumption of biofortified cassava, which has a higher concentration of Beta-carotene in the roots, represents an alternative to prevent this deficiency. Dehydrated products are an integral part of many consumers’ diet, which have preferred healthier and lower calorie foods. This study aimed to develop a dehydrated product of cassava (dehydrated chips) from biofortified varieties. The dehydrated chips were elaborated from the following biofortified cassava genotypes: BRS Dourada, BRS Gema de Ovo, BRS Jari and hybrid 2003 14-11. For obtaining the dehydrated chips, cassava roots were washed, sanitized, peeled, sliced to a thickness of 0.8 mm, blanched and dehydrated at 65 °C. First, dehydrated chips were prepared with no added flavoring, from roots of four cassava genotypes harvested at 12 months after planting, in order to select the two most suitable for dehydrated chips production based on sensory acceptance. In the second stage, dehydrated chips were produced with the addition of onion and parsley flavoring, from the two genotypes selected in the previous step. The BRS Jari variety and hybrid 2003 14-11 showed highest total carotenoid content, 10.54 ?g g g-1 and 6.92 ?g g g-1, respectively, and Beta-carotene, 8.93 ?g g g-1 and 4.98 ?g g g-1, respectively. For carotenoids and Beta-carotene retention there was no significant difference among the dehydrated chips prepared with four biofortified cassava genotypes, which showed average values of 76% and 67%, respectively. Dehydrated chips made with the BRS Jari and hybrid 2003 14-11 had highest average for flavor attribute and did not differ on the crispness and overall acceptance and classified between "like slightly” and "like moderately”. Despite the addition of "onion and parsley" flavoring, there has been no greater acceptance by consumers. Dehydrated cassava chips made with the BRS Jari variety and the hybrid 2003 14-11 showed good sensorial acceptance and higher total carotenoid and Beta-carotene contents, thus being biofortified varieties suitable for the elaboration of this product.
Safety of Navigation in the Arctic
Authors: Dyrcz Czesław 
Published: December 2017

Abstract
This article presents the results of research based on analysis of ice conditions on the Arctic Sea in recent years and consequences of these changes. The Arctic ice extent are changed due to global warming. Reducing the ice surface leads to intensification of the navigation of the waters of the Arctic Sea, resulting in a significant reduction of the distance between the ports of Europe and East Asia and the North and South Americas. This phenomenon is conducive to the opening of new shipping routes leading through the Arctic Sea. After the entry into force of 1st January, 2017 The International Code for Ships Operating in Polar Waters (Polar Code) is expected to improve the safety of conducting the navigation of the waters. Analysis of maritime accidents in the Arctic waters shows that the number of accidents has a growing trend, however, last year brings them a significant decreasing.
M 2 M Communications System Proposal for Maritime Applications
Authors: Gajewska Małgorzata 
Published: December 2017

Abstract
This article describes the proposal to use the M2M communication to enhance the safety of people, ships and other marine infrastructure, in broadly defined marine systems. In addition, there are numerous examples of planned solutions to be implemented in the near future as well as new services. The proposal for M2M communication system architecture is described below. In addition, the use of the STRUGA system radio interface as the M2M communication interface is proposed.
Automatic Identification System (AIS) Dynamic Data Estimation Based on Discrete Kalman Filter (KF) Algorithm
Authors: Jaskólski Krzysztof 
Published: December 2017

Abstract
Due to the safety reason, the ship movement on the littoral area should be monitored, tracked, recorded and stored. Automatic Identification System (AIS) is the perfect tool to ensure this requirement. The limit probability for the AIS dynamic data availability can be limited by the lack of Global Position System (GPS) signal, heading (HDG) and rate of turn (ROT) data in position report. Availability of data link is an additional limitation. For this purpose, it is possible to attach the Discrete Kalman filter (KF) for the position, and course estimation. Coordinate estimation in the absence of a transmission link can improve the quality of AIS service at Vessel Traffic Service (VTS) stations. This article presents Kalman filtering algorithm to improve the possibilities of ship motion tracking and monitoring in the TSS (Traffic Separation Scheme) and fairways area. Only 39 iterations were presented to familiarize how the Kalman filter algorithm works. The archival data from 2006 were used deliberately. During that time, there were problems with the AIS availability service. With the use of measurements series from those years, it is easier to observe the effectiveness of Kalman filter in absence of AIS data.
Next-Generation Sequencing Approach to Non–Small Cell Lung Carcinoma Yields More Actionable Alterations
Authors: Mehrad Mitra , Roy Somak , Bittar Humberto Trejo , Dacic Sanja 
Published: December 2017

Context.—
Different testing algorithms and platforms for EGFR mutations and ALK rearrangements in advanced-stage lung adenocarcinoma exist. The multistep approach with single-gene assays has been challenged by more efficient next-generation sequencing (NGS) of a large number of gene alterations. The main criticism of the NGS approach is the detection of genomic alterations of uncertain significance.

Objective.—
To determine the best testing algorithm for patients with lung cancer in our clinical practice.

Design.—
Two testing approaches for metastatic lung adenocarcinoma were offered between 2012–2015. One approach was reflex testing for an 8-gene panel composed of DNA Sanger sequencing for EGFR, KRAS, PIK3CA, and BRAF and fluorescence in situ hybridization for ALK, ROS1, MET, and RET. At the oncologist's request, a subset of tumors tested by the 8-gene panel was subjected to a 50-gene Ion AmpliSeq Cancer Panel.

Results.—
Of 1200 non–small cell lung carcinomas (NSCLCs), 57 including 46 adenocarcinomas and NSCLCs, not otherwise specified; 7 squamous cell carcinomas (SCCs); and 4 large cell neuroendocrine carcinomas (LCNECs) were subjected to Ion AmpliSeq Cancer Panel. Ion AmpliSeq Cancer Panel detected 9 potentially actionable variants in 29 adenocarcinomas that were wild type by the 8-gene panel testing (9 of 29, 31.0%) in the following genes: ERBB2 (3 of 29, 10.3%), STK11 (2 of 29, 6.8%), PTEN (2 of 29, 6.8%), FBXW7 (1 of 29, 3.4%), and BRAF G469A (1 of 29, 3.4%). Four SCCs and 2 LCNECs showed investigational genomic alterations.

Conclusions.—
The NGS approach would result in the identification of a significant number of actionable gene alterations, increasing the therapeutic options for patients with advanced NSCLCs.
Clinical significance of circulating immune cells in left- and right-sided colon cancer
Authors: Di Jiabo , Zhuang Meng , Yang Hong , Jiang Beihai , Wang Zaozao , Su Xiangqian 
Published: December 2017

Background
Left-sided and right-sided colon cancers (LCCs and RCCs, respectively) differ in their epidemiology, pathogenesis, genetic and epigenetic alterations, molecular pathways and prognosis. Notably, immune response gene expression profiles have been shown to differ between patients with LCC and patients with RCC. The immune system plays an important role in tumor immunosurveillance, and there is increasing evidence that peripheral blood immune cells have a profound influence on tumor prognosis. This study aimed to determine the clinical significance of circulating immune cells with respect to colon tumor locations.

Methods
Different types of circulating immune cells were separated and analysed based on their surface markers by flow cytometry. We compared the numbers of dendritic cells (DCs) and T cell subsets in the peripheral blood of 94 patients with RCC or LCC and analysed the proportions of these immune cells in relation to tumor stage, tumor differentiation and lymphatic metastasis.

Results
We show that at later tumor stages, patients with LCC had higher levels of circulating myeloid DCs (P = 0.049) and plasmacytoid DCs (P = 0.018) than patients with RCC. In poorly differentiated tumors, LCC patients had significantly higher amount of plasmacytoid DCs (P = 0.036), CD4+ memory T (Tm) cells (P = 0.012), CD4+ T cells (P = 0.028), Tm cells (P = 0.014), and regulatory T cells (P = 0.001) than RCC patients. The levels of circulating CD4+ T cells, Tm cells and CD4+ Tm cells were significantly elevated at later stages in patients with LCC or RCC, while these cells decreased in poorly differentiated tumors in patients with RCC. Moreover, CD4+ Tm cell and CD4+ T cell levels are significantly associated with lymph node metastasis in patients with LCC and RCC.

Discussion
Circulating immune cells were associated with tumor location, tumor stage and tumor differentiation, and can be used to predict lymphatic metastasis in patients with colon cancer. This variation in systemic immunity could contribute to the differential prognosis of patients with colon cancer.
Gendering Collaboration: Adult Education in Feminist Leadership
Authors: Clover Darlene E. , Etmanski Catherine , Reimer Rachel 
Published: December 2017

AbstractThis chapter explores the potential of feminist leadership to encourage more participatory ways of engaging and learning in this deeply troubled world. Feminist leadership includes but is not limited to collaborative leadership. Adult learning is inherent to feminist leadership insofar as leaders must strategize according to the contexts in which they find themselves.
Cocreating Collaborative Leadership Learning Environments: Using Adult Learning Principles and a Coach Approach
Authors: Page M. Beth , Margolis Rhonda L. 
Published: December 2017

AbstractAs educators, we seek to answer the following question: “What magic can happen when you believe that people are whole and resourceful and you hold the space for generative, collective wisdom?” This chapter explores collaborative leadership and learning with adult learners. We focus on creative ways to optimize learning and enhance capacity to lead self and others.
Merging Brønsted Acid and Hydrogen‐Bonding Catalysis: Metal‐Free Dearomatization of Phenols via ipso‐Friedel‐Crafts Alkylation to Produce Functionalized Spirolactams
Authors: Harada Shingo , Kwok Irene Mei‐Yi , Nakayama Hiroki , Kanda Ayaka , Nemoto Tetsuhiro 
Published: December 2017

AbstractIntramolecular dearomative cyclization of phenols with α‐diazoamide units for synthesizing functionalized spirolactams was developed by merging Brønsted acid and hydrogen‐bonding catalysis as an advantageous alternative to transition metal catalysis. This metal carbenoid‐free strategy enables high chemoselectivity by suppressing potentially competing C−H insertion reactions and a Büchner reaction. Preliminary mechanistic studies were performed to elucidate the positive effect of the combined use of the catalysts, and extension to an asymmetric reaction was achieved.magnified image
How Do Our Values Inform Ethical Research? A Narrative of Recognizing Colonizing Practices
Authors: Dzidic Peta , Bishop Brian 
Published: December 2017

AbstractHow do you reconcile tensions between ethical research practice, personal values, and disciplinary values? This article focuses on an ethical challenge involving the engagement of rural Indigenous community members that emerged during my PhD fieldwork. The narrative illustrates the necessity to engage in critical reflexive research practice, a process which saw me respond to my own feelings of “wrong” and “right,” contemplate a distinction between procedural ethics and virtue ethics in community‐based research, explore colonizing research practices, and endeavor to reconcile an instance where the values of community psychology appeared in contest. The “voice” in this narrative is that of the first author; the dual authorship reflects the ongoing collaboration between both authors. When this ethical issue came about, our relationship was one of “student” and “supervisor”; we are now colleagues and friends.
A novel thermosensitive triblock copolymer from 100% renewably sourced poly(trimethylene ether) glycol
Authors: Zhang Cong , Luan Huacheng , Wang Guiyou 
Published: December 2017

ABSTRACTBio‐based amphiphilic triblock copolymers with 100% renewably sourced poly(trimethylene ether) glycol (PO3G) as the hydrophobic blocks and statistical copolymer of 2‐(2‐methoxyethoxy)ethyl methacrylate (MEO2MA) and oligo(ethylene glycol)methacrylate (OEGMA) [P(MEO2MA‐stat‐OEGMA)] as the hydrophilic blocks are synthesized and characterized. It is found that the molar ratio of MEO2MA/OEGMA among the resulting copolymers is approximately 70/30. The degree of polymerization (DP) of P(MEO2MA‐stat‐OEGMA) block ranges from 16 to 90, and the DP of PO3G block is fixed at 35. The amphiphilic copolymers could form core‐shell micelles self‐assembly in aqueous solution at low concentrations, and the micelles are in spherical shape with sizes varying from 121 to 188 nm. With the increasing length of hydrophilic blocks, the critical micelle concentration increases from 2.15 to 13.8 mg L−1, and the lower critical solution temperature improves from 32.5 to 38.4 °C. The in vitro doxorubicin (DOX) release study shows that all DOX‐loaded micelles have a higher release rate at 37 °C than that at 25 °C. Cytotoxicity test reveals that the blank micelles are nearly nontoxic. These results indicate that the block copolymer micelles containing 100% renewably sourced PO3G can serve as a potential drug delivery carrier. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46112.