bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resolving Hydrometeorological Data Discontinuities along an International Border
Authors: Gronewold Andrew D. , Fortin Vincent , Caldwell Robert , Noel James 
Published: November 2017

AbstractMonitoring, understanding, and forecasting the hydrologic cycle of large freshwater basins often requires a broad suite of data and models. Many of these datasets and models, however, are susceptible to variations in monitoring infrastructure and data dissemination protocols when watershed, political, and jurisdictional boundaries do not align. Reconciling hydrometeorological monitoring gaps and inconsistencies across the international Laurentian Great Lakes–St. Lawrence River basin is particularly challenging because of its size and because the basin’s dominant hydrologic feature is the vast surface waters of the Great Lakes.For tens of millions of Canadian and U.S. residents that live within the Great Lakes basin, seamless binational datasets are needed to better understand and predict coastal water-level fluctuations and other conditions that could potentially threaten human and environmental health. Binational products addressing this need have historically been developed and maintained by the Coordinating Committee on Great Lakes Basic Hydraulic and Hydrologic Data (Coordinating Committee). The Coordinating Committee recently held its one-hundredth semiannual meeting and reflected on a range of historical accomplishments while setting goals for future work. This article provides a synthesis of those achievements and goals. Particularly significant legacy and recently developed datasets of the Coordinating Committee include historical Great Lakes surface water elevations, basin-scale tributary inflow to the Great Lakes, and basin-scale estimates of both over-lake and over-land precipitation. Moving forward, members of the Coordinating Committee will work toward customizing state-of-the-art hydrologic and meteorological forecasting systems across the entire Great Lakes basin and toward promoting their products and protocols as templates for successful binational coordination across other large binational freshwater basins.
The Effect of Human Adipose Tissue–Derived Mesenchymal Stem Cells in Rat’s Subglottic Stenosis Model
Authors: Oh Seyeon , Kim Dong Young , Baek Min Kwan , Byun Kyunghee , Woo Joo Hyun 
Published: November 2017

Objective: Subglottic stenosis remains a clinical challenge. The aim of this study was to evaluate the effect of human adipose tissue–derived mesenchymal stem cells (hAMSCs) in rat model of subglottic stenosis. Subjects and Methods: Ninety-six 13-week-old male rats were enrolled in this study. They were divided into 3 groups as normal control (NC) group, a subglottic injury and media injection (SM) group, and a subglottic injury and media-stem cell injection (SMSC) group. The hAMSCs were immediately injected into subglottis after injury. Histologic characteristics of subglottis; the mRNA expressions of interleukin-1β, cyclooxygenase-2, tumor growth factor-β and basic fibroblast growth factor; and hAMSCs’ survival were evaluated. Results: The hAMSCs survived in the subglottis of the rat until 10 days after implantation. The NC and SMSC groups had a significantly wider subglottic lumen and thinner lamina propria than the SM group at 56 days after injury. Collagen intensity of subglottis was significantly higher in the SM group than in the NC and SMSC groups at 28 days after injury. Gene expression didn’t show significant difference between the SM group and the SMSC group. Conclusions: The hAMSCs injection was found to be helpful for preventing subglottic stenosis in a rat model.
Simplified Summative Temporal Bone Dissection Scale Demonstrates Equivalence to Existing Measures
Authors: Pisa Justyn , Gousseau Michael , Mowat Stephanie , Westerberg Brian , Unger Bert , Hochman Jordan B. 
Published: November 2017

Introduction: Emphasis on patient safety has created the need for quality assessment of fundamental surgical skills. Existing temporal bone rating scales are laborious, subject to evaluator fatigue, and contain inconsistencies when conferring points. To address these deficiencies, a novel binary assessment tool was designed and validated against a well-established rating scale. Methods: Residents completed a mastoidectomy with posterior tympanotomy on identical 3D-printed temporal bone models. Four neurotologists evaluated each specimen using a validated scale (Welling) and a newly developed “CanadaWest” scale, with scoring repeated after a 4-week interval. Results: Nineteen participants were clustered into junior, intermediate, and senior cohorts. An ANOVA found significant differences between performance of the junior-intermediate and junior-senior cohorts for both Welling and CanadaWest scales ( P < .05). Neither scale found a significant difference between intermediate-senior resident performance ( P > .05). Cohen’s kappa found strong intrarater reliability (0.711) with a high degree of interrater reliability of (0.858) for the CanadaWest scale, similar to scores on the Welling scale of (0.713) and (0.917), respectively. Conclusion: The CanadaWest scale was facile and delineated performance by experience level with strong intrarater reliability. Comparable to the validated Welling Scale, it distinguished junior from senior trainees but was challenged in differentiating intermediate and senior trainee performance.
Qualitative analysis of the capacity to consent to treatment in patients with a chronic neurodegenerative disease: Alzheimer’s disease / Analisi qualitativa sulla capacità a prestare consenso al trattamento in pazienti con malattie cronico degenerative neuropsicoorganiche: Demenza di Alzheimer
Authors: Carabellese Felice , Felthous Alan R , La Tegola Donatella , Piazzolla Giuseppina , Distaso Salvatore , Logroscino Giancarlo , Leo Antonio , Ventriglio Antonio , Catanesi Roberto 
Published: November 2017

Objective: Informed consent is an essential element in doctor–patient relationship. In particular, obtaining valid informed consent from patients with neurocognitive diseases is a critical issue at present. For this reason, we decided to conduct research on elderly patients with Alzheimer’s disease ( Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) to assess their capacity to make treatment decisions. Methods: The experimental group comprised 70 Alzheimer patients who were admitted to the Neurodegenerative Disease Unit of the University of Bari. The control group consisted of 83 elderly patients without neurocognitive disorders who were hospitalized in the Geriatric Unit at the same university. After providing written consent to participate in the research, each subject underwent the following assessments: (a) assessment of comprehension sheet, (b) Neuropsychiatric Inventory (NPI) and Global Functioning Evaluation (GFE), (c) neurological evaluation, (d) neuropsychological assessment with a full battery of tests, (d) The MacArthur Treatment Competence Study (MacArthur Competence Assessment Tool for Treatment (MacCAT-T); understanding, appreciating, reasoning and expressing a choice) and (e) a semi-structured interview administered by the patient’s caregiver. Results/conclusion: The present survey was designed to analyze possible qualitative and quantitative correlations between cognitive functioning and capacity to consent in relation to different degrees of severity of the neurodegenerative disorder. A large portion of the patients in our experimental sample did not appear to have the capacity to provide a valid consent. The authors present initial results of this study and discuss their possible implications.
On the forces of policy change and joint causation: insights from the banker’s bonus case
Authors: Braun Caelesta , Scherpenisse Jorren , van der Steen Martijn , van Twist Mark J.W. 
Published: November 2017

One of the few robust findings in the public policy literature is that policy dynamics are both a function of stability and volatility. And although most theories of public policy making posit the occurrence of policy junctures as necessary conditions for significant change, studies that set out to unravel the underlying mechanisms of such policy junctures remain relatively rare. This article further develops the idea of policy junctures, commonly hypothesized to initiate significant change, as essentially entailing joint causation. We illustrate the joint and reinforcing nature of forces of change with a case study of bonus regulation. Based on document analysis and a political claim analysis, this article shows that most changes in bonus regulation were of a marginal nature. We argue that the intrinsically attractive nature of performance rewards that a bonus practice entails combined with a sheer lack of alternatives supported by a strong coalition on how to curb risk appetite in financial markets seem to count for the resilience of bonus practices. Theoretically, the case study contributes to theory development on joint causation that causes major policy change. Empirically, it unravels a key mechanism employed by the financial sector to resist reforms: offering an alternative no one can refuse. Points for practitioners There is a broad consensus in the policy literature that policy change usually results from multiple forces. We identify this crucial jointly causal nature of policy change and suggest that among the forces of change a strong policy alternative capable of uniting a broad coalition of stakeholders is a necessary condition for policy change. Financial reforms, in particular the practice of bonus payment, are thus not likely to result from tight regulation, but rather from real alternatives on how to reward professional excellence and curb risk appetite.
How innovation drivers, networking and leadership shape public sector innovation capacity
Authors: Lewis Jenny M. , Ricard Lykke Margot , Klijn Erik Hans 
Published: November 2017

The need to understand innovation in public sector environments is growing. There is also a need to build theory, test it empirically and compare across jurisdictions. This article aims to understand the factors that have an impact on innovation capacity. It examines the self-rated innovation capacity of three European city governments – Barcelona, Copenhagen and Rotterdam – in regard to innovation drivers (structures, processes and contextual factors), external networking (levels of communication outside the municipality) and leadership qualities. Results from an online survey of senior administrators in the cities ( n = 323) was used to empirically analyse the relationships between these using a structural equation model. Leadership has a stronger effect than innovation drivers and external networking on self-rated innovation capacity for these three city governments. Points for practitioners Public sector innovation is a very important topic for public managers as the expectations on government agencies increase. Innovation capacity is related to innovation drivers and barriers, the amount of contact that individuals have with others outside their organization, and leadership. This empirical study of three cities shows that leadership has a bigger effect on innovation capacity than the structures, processes and contextual factors that drive innovation, as well as the amount of external contact that public managers have outside their organizations. In addition, for Barcelona and Copenhagen, the network governance and transformational types have the biggest effect on innovation, while for Rotterdam, it is the entrepreneurial type followed by the network governance type.
Cross-Sectional Study to Assess the Functional Outcome of Neglected Bimalleolar Fracture
Authors: Shukla Rajeev , Jain Ravi Kant , Patidar Shravan , Jain Nikhil , Mahajan Pranav 
Published: November 2017

Introduction. Ankle fracture is the most common intra-articular fracture of a weight-bearing joint and accounts for 9% of all fractures. Ankle fractures are classified into 3 subgroups: unimalleolar, bimalleolar, and trimalleolar fractures. Accurate reduction and stable internal fixation is necessary in bimalleolar fractures; otherwise, it may lead to posttraumatic painful restriction of movements or osteoarthritis. The purpose of this study is to assess the functional outcome and results of treatment of neglected bimalleolar fracture. Materials and Methods. Seventeen neglected bimalleolar fracture patients were treated with open reduction and internal fixation. Patients were followed-up at 1, 2, and 5 years and functional ability was assessed by using the modified Weber Rating Scale. Results. The mean age of patients was 41.4 ± 13.28 years. After 2 year of surgery, 13 out of 17 patients showed excellent results and 4 patients had fair results. Conclusion. Good to excellent functional results were observed after long-term follow-up in neglected bimalleolar fracture treated with open reduction and internal fixation, and we advise surgical intervention in all such patients. Levels of Evidence: Therapeutic, Level III: Retrospective Cohort study
Marathon running increases circulating endothelial- and thrombocyte-derived microparticles
Authors: Schwarz Viktoria , Düsing Philip , Liman Thomas , Werner Christian , Herm Juliane , Bachelier Katrin , Krüll Matthias , Brechtel Lars , Jungehulsing Gerhard J , Haverkamp Wilhelm , Böhm Michael , Endres Matthias , Haeusler Karl Georg , Laufs Ulrich 
Published: November 2017

Background Acute vascular effects of high intensity physical activity are incompletely characterized. Circulating microparticles are cellular markers for vascular activation and damage. Methods Microparticles were analysed in 99 marathon runners (49 ± 6 years, 22% female) of the prospective Berlin Beat of Running study. Blood samples were taken within three days before, immediately after and within two days after the marathon run. Endothelial-derived microparticles were labelled with CD144, CD31 and CD62E, platelet-derived microparticles with CD62P and CD42b, leukocyte-derived microparticles with CD45 and monocyte-derived microparticles with CD14. Results Marathon running induced leukocytosis (5.9 ± 0.1 to 14.8 ± 0.3 109/l, p < 0.0001) and increased platelet counts (239 ± 4.6 to 281 ± 5.9 109/l, p < 0.0001) immediately after the marathon. Blood monocytes increased and lymphocytes decreased after the run ( p < 0.0001). Endothelial-derived microparticles were acutely increased ( p = 0.008) due to a 23% increase of apoptotic endothelial-derived microparticles ( p = 0.007) and returned to baseline within two days after the marathon. Thrombocyte-derived microparticles acutely increased by 38% accompanied by an increase in activated and apoptotic thrombocyte-derived microparticles ( p ≤ 0.0001) each. Both monocyte- and leukocyte-derived microparticles were decreased immediately after marathon run ( p < 0.0001) and remained below baseline until day 2. Troponin T increased from 12 to 32 ng/l ( p < 0.0001) immediately after the run and returned to baseline after two days. Conclusion Circulating apoptotic endothelial- and thrombocyte-derived microparticles increased after marathon running consistent with an acute pro-thrombotic and pro-inflammatory state. Exercise-induced vascular damage reflected by microparticles could indicate potential mechanisms of post-exertional cardiovascular complications. Further studies are warranted to investigate microparticles as markers to identify individuals prone to such complications.
Nbeal2 interacts with Dock7, Sec16a, and Vac14
Authors: Mayer Louisa , Jasztal Maria , Pardo Mercedes , Aguera de Haro Salvadora , Collins Janine , Bariana Tadbir K. , Smethurst Peter A. , Grassi Luigi , Petersen Romina , Nurden Paquita , Favier Rémi , Yu Lu , Meacham Stuart , Astle William J. , Choudhary Jyoti , Yue Wyatt W. , Ouwehand Willem H. , Guerrero Jose A. 
Published: November 2017

Key PointsNbeal2 interacts with Dock7, Sec16a, and Vac14; and missense variants that cause GPS disrupt the binding of Dock7 and Vac14. The level of the α-granule protein Dock7 in platelets from Nbeal2−/− mice and GPS cases is reduced and its signaling pathway is dysregulated.
Copula-based composite likelihood approach for frequency analysis of short annual precipitation records
Authors: Wei Ting , Song Songbai 
Published: November 2017

Abstract
Hydrological series lengths are decreasing due to decreasing investments and increasing human activities. For short sequences, a copula-based composite likelihood approach (CBCLA) has been employed to enhance the quality of hydrological design values. However, the Pearson type III (P-III) distribution for short annual precipitation records has not yet been thoroughly investigated using the CBCLA. This study used the CBCLA to incorporate the concurrent and non-concurrent periods contained in data of various lengths into an integrated framework to estimate the parameters of precipitation frequency distributions. The marginal distributions were fitted using the P-III distribution, and the joint probability was constructed using a copula which offers flexibility in choosing arbitrary marginals and dependence structure. Furthermore, the uncertainties in the estimated precipitation design values for the short series obtained from this approach were compared with those obtained from univariate analysis. Then, Monte-Carlo simulations were performed to examine the feasibility of this approach. The annual precipitation series at four stations in Weihe River basin, China, were used as a case study. Results showed that CBCLA with P-III marginals reduced the uncertainty in the precipitation design values for the short series and the reduction in the uncertainty became more significant with longer adjacent series.
Fluoride ion adsorption from wastewater using magnesium(II), aluminum(III) and titanium(IV) modified natural zeolite: kinetics, thermodynamics, and mechanistic aspects of adsorption
Authors: Ma Zhijun , Zhang Qi , Weng Xingyuan , Mang Changye , Si Liwei , Guan Zhihao , Cheng Liang 
Published: November 2017

Abstract
Natural zeolite was modified using metal ions, including magnesium(II), aluminum(III) and titanium(IV). The modified zeolite was then used as an adsorbent for the investigation of the adsorption kinetics, isotherms, and thermodynamic parameters of fluoride ions in wastewater at various pHs and temperatures. The kinetics and thermodynamics for the removal of the fluoride ions onto the modified zeolite have also been investigated. The fluoride ion adsorption capacity of the three types of modified zeolites exhibited an increase, then decrease, with rising pH. The fluoride adsorption capacity of the modified zeolites decreased with an increase in temperature. The pseudo-second-order model is more suitable for describing the adsorption kinetic data than the pseudo-first-order model for modified zeolite and the adsorption process of the fluoride ions reveals pseudo-second-order kinetic behavior, respectively. It was found that the adsorption equilibrium data fit the Freundlich isothermal equation better than that of the Langmuir isothermal and Dubinin–Radushkevich (D–R) isothermal equations. Thermodynamic analysis suggests that the negative values of ΔG0 and ΔH0 further indicate that the fluoride adsorption process is both spontaneous and exothermic. The results of competitive adsorption tests suggest that the modified metal zeolite materials adsorb fluoride ions with high selectivity.
Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD
Authors: Shah Hetal S. , Morieri Mario Luca , Marcovina Santica M. , Sigal Ronald J. , Gerstein Hertzel C. , Wagner Michael J. , Motsinger-Reif Alison A. , Buse John B. , Kraft Peter , Mychaleckyj Josyf C. , Doria Alessandro 
Published: November 2017

OBJECTIVEA genome-wide association study in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial identified two markers (rs57922 and rs9299870) that were significantly associated with cardiovascular mortality during intensive glycemic control and could potentially be used, when combined into a genetic risk score (GRS), to identify patients with diabetes likely to derive benefit from intensive control rather than harm. The aim of this study was to gain insights into the pathways involved in the modulatory effect of these variants.RESEARCH DESIGN AND METHODSFasting levels of 65 biomarkers were measured at baseline and at 12 months of follow-up in the ACCORD-Memory in Diabetes (ACCORD-MIND) MRI substudy (n = 562). Using linear regression models, we tested the association of the GRS with baseline and 12-month biomarker levels, and with their difference (Δ), among white subjects, with genotype data (n = 351) stratified by intervention arm.RESULTSA significant association was observed between GRS and ΔGLP-1 (glucagon-like peptide 1, active) in the intensive arm (P = 3 × 10−4). This effect was driven by rs57922 (P = 5 × 10−4). C/C homozygotes, who had been found to derive cardiovascular benefits from intensive treatment, showed a 22% increase in GLP-1 levels during follow-up. By contrast, T/T homozygotes, who had been found to experience increased cardiac mortality with intensive treatment, showed a 28% reduction in GLP-1 levels. No association between ΔGLP-1 and GRS or rs57922 was observed in the standard treatment arm.CONCLUSIONSDifferences in GLP-1 axis activation may mediate the modulatory effect of variant rs57922 on the cardiovascular response to intensive glycemic control. These findings highlight the importance of GLP-1 as a cardioprotective factor.
Compare Of the West Syndrome with Other Syndromes in the Epileptic Encephalopathy - Kosovo Experience
Authors: Zeka Naim , Gerguri Abdurrahim , Bejiqi Ramush , Retkoceri Ragip , Vuciterna Armend 
Published: November 2017

BACKGROUND: West Syndrome (WS) represents as a specific epileptic encephalopathy characterised with a unique type of attacks, called infantile spasms, severe forms of abnormalities in electroencephalographic (EEG) records as a hypsarythmias and delays in the psychomotoric development. The characteristics of the disease, mostly affecting male gender, are infantile spasms and typical findings in EEG as a hypsarythmia. Infantile spasms are a consequence of many factors in the undeveloped brain.AIM: We aimed: (1) to see the incidence of the illness and the spreading out because of gender in rapport with other syndromes in the epileptic encephalopathies group; (2) to show principles of the treatment for the illness; and (3) to present the effects of the disease in the psycho-motoric development of affected children.METHODS: The study was designed as a cross-sectional study of the patients with epileptic encephalopathies, treated in Paediatric Clinic in Prishtina, from 1st of January 2013 until the 31st of December 2015. RESULTS: From the cohort group of 97 children diagnosed with epileptic encephalopathies, in 14 of them clinical and EEG signs of WS were noted. The earliest age of disease manifestation was 74 days (± 63.8 days). On the group of children with WS, 13 of them with Natrium Valpropat were treated, with the doses of 301.9 mg (± 64.1). From the cohort group, in 89 children (91.8%) psychomotoric retardation was documented, within the higher reoccurrence in the undifferentiated epileptic encephalopathies (96%) and the WS (78.6%).CONCLUSION: WS is a frequent disease of the encephalopathies with the epileptogenic framework. The resistance in anticonvulsive therapy is huge, and psychomotoric retardation follows a big percentage of children with this syndrome.