bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell phone use is associated with an inflammatory cytokine profile of parotid gland saliva
Authors: Siqueira Elisa Carvalho , de Souza Fabrício Tinôco Alvim , Ferreira Efigênia , Souza Renan Pedra , Macedo Samuel Costa , Friedman Eitan , Gomez Marcus Vinícius , Gomes Carolina Cavaliéri , Gomez Ricardo Santiago 
Published: February 2016

BackgroundThere is controversy on the effects of the non‐ionizing radiation emitted by cell phones on cellular processes and the impact of such radiation exposure on health. The purpose of this study was to investigate whether cell phone use alters cytokine expression in the saliva produced by the parotid glands.MethodsCytokine expression profile was determined by enzyme linked immuno sorbent assay (ELISA) in the saliva produced by the parotid glands in healthy volunteers, and correlated with self‐reported cell phone use and laterality.ResultsThe following parameters were determined, in 83 Brazilian individuals in saliva produced by the parotid glands comparing the saliva from the gland exposed to cell phone radiation (ipsilateral) to that from the contralateral parotid: salivary flow, total protein concentration, interleukin 1 β (IL‐1 β), interleukin 6 (IL‐6), interleukin 10 (IL‐10), interferon γ (IFN‐γ), and tumor necrosis factor α (TNF‐α) salivary levels by ELISA. After multiple testing correction, decreased IL‐10 and increased IL‐1β salivary levels in the ipsilateral side compared with the contralateral side (P < 0.05) were detected. Subjects who used cell phones for more than 10 years presented higher differences between IL‐10 levels in ipsilateral versus contralateral parotids (P = 0.0012). No difference was observed in any of the tested parameters in correlation with cell phone monthly usage in minutes.ConclusionThe exposure of parotid glands to cell phones can alter salivary IL‐10 and IL‐1β levels, consistent with a pro‐inflammatory microenvironment that may be related to heat production.
Adverse effects of a 10‐day course of ibuprofen inHolstein calves
Authors: Walsh P. , Carvallo Chaigneau F. R. , Anderson M. , Behrens N. , McEligot H. , Gunnarson B. , Gershwin L. J. 
Published: February 2016

Nonsteroidal anti‐inflammatory drugs (NSAIDs) are recommended for various conditions in cattle. Ibuprofen is an inexpensive short‐actingNSAIDand is readily available in liquid formulation for administration to bottle‐fed calves. We compared the adverse effects of a 10‐day course of ibuprofen and placebo in 16 five‐ to six‐week‐old Holstein bull calves that were being treated for experimentally induced bovine respiratory syncytial virus infection. Ibuprofen was administered as a liquid in milk replacer at 30 mg/kg divided three times daily. We found an increased prevalence of abomasal ulceration 5 of 8 in the ibuprofen compared to placebo group 2 of 6 (P = NS). There was one (1 of 8) case of mild interstitial nephritis in the ibuprofen and none (0 of 8) in the placebo group (P = NS). Renal function as measured by serumBUNand creatinine levels was not different between groups; no animal demonstrated an increase in creatinine.
Studying auditory verbal hallucinations using the RDoC framework
Authors: Ford Judith M. 
Published: February 2016

AbstractIn this paper, I explain why I adopted a Research Domain Criteria (RDoC) approach to study the neurobiology of auditory verbal hallucinations (AVH), or voices. I explain that the RDoC construct of “agency” fits well with AVH phenomenology. To the extent that voices sound nonself, voice hearers lack a sense of agency over the voices. Using a vocalization paradigm like those used with nonhuman primates to study mechanisms subserving the sense of agency, we find that the auditory N1 ERP is suppressed during vocalization, that EEG synchrony preceding speech onset is related to N1 suppression, and that both are reduced in patients with schizophrenia. Reduced cortical suppression is also seen across multiple psychotic disorders and in clinically high‐risk youth, but it is not related to AVH. The motor activity preceding talking and connectivity between frontal and temporal lobes during talking have both proved sensitive to AVH, suggesting neural activity and connectivity associated with intentions to act may be a better way to study agency and predictions based on agency.
Using the NIMH Research Domain Criteria (RDoC) in human and nonhuman primate research
Authors: Maestripieri Dario , Lilienfeld Scott O. 
Published: February 2016

AbstractIn this article, we provide a commentary on Kozak and Cuthbert ()'s theoretical paper discussing the NIMH Research Domain Criteria (RDoC) initiative and on Latzman et al. (2016)'s empirical investigation of the RDoC negative valence systems domain in chimpanzees, conducted with experimental procedures across genetic, neurobiological, and behavioral levels of analysis. We discuss the pros and cons of the RDoC approach to research on mental illness as well as the strengths and weaknesses of the implementation of this approach in the chimpanzee study.
The NIMH Research Domain Criteria initiative and error‐related brain activity
Authors: Hanna Gregory L. , Gehring William J. 
Published: February 2016

AbstractResearch on the neural response to errors has an important role in the Research Domain Criteria (RDoC) project, since it is likely to link psychopathology to the dysfunction of neural systems underlying basic behavioral functions, with the error‐related negativity (ERN) appearing as a unit of measurement in three RDoC domains. A recent report builds on previous research by examining the ERN as a measure of the sustained threat construct and providing evidence that the ERN may reflect sensitivity more specifically to endogenous threat. Data from 515 adolescent females indicate that the ERN was enlarged primarily in older adolescents with self‐reported checking behaviors, although it was blunted in adolescents with depressive symptoms regardless of age. Potential future studies for replicating and extending the research on the ERN and obsessive‐compulsive (OC) behaviors are discussed, including studies that more fully characterize OC symptom dimensions, studies that integrate other measures of error‐related brain activity and use computational modeling, studies that combine longitudinal, family, and molecular genetic measures, and interventional studies that specifically modulate error‐related brain activity in individuals with OC behaviors.
Psychobiological operationalization of RDoC constructs: Methodological and conceptual opportunities and challenges
Authors: MacNamara Annmarie , Phan K. Luan 
Published: February 2016

AbstractNIMH's Research Domain Criteria (RDoC) project seeks to advance the diagnosis, prevention, and treatment of mental disorders by promoting psychobiological research on dimensional constructs that might cut across traditional diagnostic boundaries (Kozak & Cuthbert, ). At the core of this approach is the notion that these dimensional constructs can be assessed across different units of analysis (e.g., genes, physiology, behavior), enriching the constructs and providing more complete explanations of clinical problems. While the conceptual aspects of RDoC have been discussed in several prior papers, its methodological aspects have received comparatively less attention. For example, how to integrate data from different units of analysis has been relatively unclear. Here, we discuss one means of psychobiologically operationalizing RDoC constructs across different units of analysis (the psychoneurometric approach; Yancey et al., ), highlighting ways in which this approach might be refined in future iterations. We conclude that there is much to be learned from this technique; however, greater attention to scale‐development methods and to psychometrics will likely benefit this and other methodological approaches to combining measurements across multiple units of analysis.
Taking an RDoC lens to the study of panic disorder: A commentary on Hamm et al. and other thoughts on RDoC
Authors: Shankman Stewart A. , Katz Andrea C. , Langenecker Scott A. 
Published: February 2016

AbstractThe Research Domain Criteria (RDoC) initiative put forth by the National Institute of Mental Health represents an exciting new framework in which to study psychopathology. The article by Hamm et al. (2016) is an interesting application of an “RDoC lens” toward a program of research on panic disorder. This commentary highlights the many strengths of the Hamm et al. (2016) study—most notably the article's application of a well‐studied animal model of anxiety (Fanselow's, , threat imminence model) to humans, utilization of an interesting behavioral paradigm (as an analog for avoidance behaviors in panic disorder), and using RDoC to examine predictors of treatment response. This commentary also discusses several questions about RDoC that arise out of Hamm et al. For example, (a) How should participants be selected for RDoC studies? (b) Are RDoC constructs risk factors (and risk factors for what)? (c) Besides Hamm et al.'s, approach, how else can RDoC be used in treatment studies? In sum, Hamm et al. is a very good example of an RDoC study, and in this early phase of the initiative, more examples for how the approach plays out are needed.
RDoC: Translating promise into progress
Authors: Patrick Christopher J. , Hajcak Greg 
Published: February 2016

AbstractAs highlighted by articles in the current special issue, the RDoC initiative holds promise for advancing understanding of mental health problems. However, the initiative is at its early stages and it remains unclear what level of progress can be achieved and how quickly. In this closing article, we identify major challenges facing RDoC and propose concrete approaches to addressing these challenges, including (a) clearer specification of clinical problems for study, with use of symptom dimensions from integrative dimensional models of psychopathology as provisional, modifiable referents; (b) encouragement of research on a distinct set of traits corresponding to process constructs from the RDoC matrix—those represented across animal, child temperament, and adult personality literatures—to serve as interfaces between matrix constructs and clinical problems; (c) an emphasis in the near term on use of proximal units of analysis in RDoC studies—in particular, on physiological, behavioral, and self‐report measures of matrix constructs (examined as states or traits, or both); (d) inclusion of a clear ontogenetic‐developmental component in RDoC research projects; (e) routine analysis of the psychometric properties of nonreport (e.g., physiological, task‐behavioral) variables, including systematic evaluation of their reliability and convergent‐discriminant validity; (f) modification of existing grant review criteria to prioritize replication and synergy in RDoC investigative work; and (g) creation of a cumulative data network system (RDoC–DataWeb) to encourage and facilitate coordination of research efforts across RDoC research groups.
Reshaping clinical science: Introduction to the Special Issue on Psychophysiology and the NIMH Research Domain Criteria (RDoC) initiative
Authors: Patrick Christopher J. , Hajcak Greg 
Published: February 2016

AbstractThe National Institute of Mental Health's (NIMH) Research Domain Criteria (RDoC) initiative seeks to establish new dimensional conceptions of mental health problems, through the investigation of clinically relevant “process” constructs that have neurobiological as well as psychological referents. This special issue provides a detailed overview of the RDoC framework by NIMH officials Michael Kozak and Bruce Cuthbert, and spotlights RDoC‐oriented investigative efforts by leading psychophysiological research groups as examples of how clinical science might be reshaped through application of RDoC principles. Accompanying commentaries highlight key aspects of the work by each group, and discuss reported methods/findings in relation to promises and challenges of the RDoC initiative more broadly.
AEROLLER: HERBICIDES ROLLER MACHINE FOR AEROBIC RICE WEED CONTROL
Authors: K. Mohd Khusairy , H. Ayob , C. S. Chan , M. I. Mohamed Fauzi , O. Mohamad Fakhrul Zaman , GS. M. Shahril Shah , O. Azlan , M. Abdul Rasad , A. Mohd Hashim , M. N. Saifulizan 
Published: February 2016

As wet land rice, aerobic rice is also faced with the problem of weeds management. The absences of stagnant water facilitating more weed species to survive and compete with rice plants. Therefore, soil preparation is crucial for reduce weed problems in addition to manual control, which focuses on the rate of herbicides, the growth of rice plants, plant moisture and weed species. The risk of spray drift would be eliminated if herbicides were wiped on to weeds rather than sprayed. A machine designed to apply herbicides using rolling wipers were assessed for their ability to apply constant amounts of herbicide to treated surfaces. The machine designed by developed a structure consist of weed ball applicator, a hose connect to a 300 liter reservoir tank which attached to the transplanter prime mover. Weed ball applicator treated strips 15cm wide and having a roller 100 cm length. Adjustments to the flow rate as the reservoir can be made using a control valve at weed ball devices and control valve at the reservoir tank. AeRoller application used by wipe the herbicide onto weeds instead of spraying. The risk of damage to nearby non target plant would be almost eliminated and treatment under windy conditions would be possible by wiping herbicide on to weeds rather than spraying. A field evaluation of the Aeroller showed that it had good potential for the applications of herbicides for controlling weeds on aerobic rice farm. The use of this rollers device system saves chemicals, reduce labor, reduce pollution on the environment and reduce worker exposure to dangerous herbicides.
Rare extrapulmonary complications ofMycoplasma pneumoniaeinfection
Authors: Dhaliwal Kiran , Enright Kevin 
Published: February 2016

Stevens-Johnsons syndrome (SJS) is a rare extra-pulmonary complication ofMycoplasma pneumoniaeinfection. We present the case of a 26-year-old man with fever, cough, extensive oral mucosal ulceration and a widespread truncal rash. He was diagnosed withM. pneumoniae-induced SJS. He responded well to antibiotics and steroids initially, but went on to develop pseudomembranous conjunctivitis requiring bilateral amniotic membrane grafting.SJS is most commonly drug-induced, however,M. pneumoniaeis the commonest infectious cause and should be considered in the differential diagnosis. It is also important to get specialist care involved early to minimise the long-term effects of any complications.
The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis
Authors: Fisher Oliver M , Lord Sarah J , Falkenback Dan , Clemons Nicholas J , Eslick Guy D , Lord Reginald V 
Published: February 2016

ObjectiveTo clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC.DesignA systematic review was conducted using MEDLINE, Embase, PubMed and Current Contents Connect to identify studies published between January 1990 and February 2015 of oesophageal cancer populations (with OAC diagnoses >50% of cases) that measured tumoural TP53 status and reported hazard ratios (HR), or adequate data for estimation of HR for survival for TP53-defined subgroups. Risk of bias for HR estimates was assessed using prespecified criteria for the appraisal of relevant domains as defined by the Cochrane Prognosis Methods Group including adherence to Grading of Recommendations, Assessment, Development and Evaluation and REporting recommendations for tumor MARKer prognostic studies guidelines, as well as assay method used (direct TP53 mutation assessment vs immunohistochemistry) and adjustment for standard prognostic factors. A pooled HR and 95% CI were calculated using a random-effects model.ResultsSixteen eligible studies (11 with OAC only and 5 mixed histology cohorts) including 888 patients were identified. TP53 mutations were associated with reduced survival (HR 1.48, 95% CI 1.16 to 1.90, I2=33%). A greater prognostic effect was observed in a sensitivity analysis of those studies that reported survival for OAC-only cohorts and were assessed at low risk of bias (HR 2.11, 95% CI 1.35 to 3.31, I2=0%).ConclusionsPatients with OAC and TP53 gene mutations have reduced overall survival compared with patients without these mutations, and this effect is independent of tumour stage.
Synthesis and characterization of nanocrystalline LaMnO3 modified BaTiO3 ferroelectric ceramics prepared by chemical route
Authors: Dhak Prasanta , Adak Mrinal Kanti , Dhak Debasis 
Published: February 2016

Nanocrystalline Ba[Formula: see text]Ti[Formula: see text]La[Formula: see text]Mn[Formula: see text]O3, [[Formula: see text] = 0.006, 0.008, 0.01 and 0.05] (abbreviated hereafter as BTLM) by chemical route. The phase formation and purity were checked by X-ray diffraction (XRD) study and transmission electron microscopy (TEM). The grain morphology after sintering was studied by scanning electron microscopy (SEM). The crystallite sizes range from 21 nm to 30 nm, while the particle size ranges between 27 nm and 38 nm. The grain size 212 nm and grain density 96.8% were found to be maximum for BTLM [Formula: see text] = 0.05 and [Formula: see text] = 0.01, respectively. The temperature dependence of dielectric constants was found to be more diffused and the peak value of the dielectric constant was decreased and more flat with the increase of the substituent concentration. The tangent loss was found to be decreased and reached to the minimum value of 0.032 for BTLM [Formula: see text] = 0.05. The remnant polarization [Formula: see text], was 10 [Formula: see text]C/cm2 for BTLM [Formula: see text] = 0.01.
Tobacco Causes Human Cancers—A Concept Founded on Epidemiology and an Insightful Experiment Now Requires Translation Worldwide
Authors: Loeb Lawrence A. 
Published: February 2016

Abstract
The recognition that tobacco smoke is carcinogenic led to the most significant and successful effort at reducing cancer incidence in human history. A major milestone of this effort was the publication in Cancer Research by Wynder and colleagues, which demonstrated the ability of tobacco tars to produce tumors in mice. This study provided a powerful link between the epidemiology of cancer and mechanisms of carcinogenesis. This commentary asserts that we have a moral obligation to translate our success in reducing lung cancer in the United States to the 1.25 billion smokers throughout the rest of the world. Cancer Res; 76(4); 765–6. ©2016 AACR.
See related article by Wynder et al., Cancer Res 1953;13:855–64.
Using Synthetic Tropical Cyclones to Characterize Extreme Hurricanes Affecting Charleston, South Carolina
Authors: Ellis Kelsey N. , Trepanier Jill C. , Hodges Robert E. 
Published: February 2016

AbstractThe characteristics and conditions favoring extreme hurricanes remain largely unknown because of their small number in the observational record. Synthetic tracks are capable of providing a large, representative sample of these events, which provides an opportunity to further understanding of extreme characteristics as compared with those of more common tropical cyclones. The authors compare 300 synthetic extreme (100-yr event, ≥48.9 m s−1) and 300 common (5-yr event, ≤33.6 m s−1) tropical cyclones for Charleston, South Carolina, for differences in spatial, temporal, and other characteristics. Results suggest that extreme hurricanes have a more-defined spatial and temporal behavior, generally forming off the coast of Africa and making a direct landfall at Charleston. Common tropical cyclones sometimes make prior landfalls, may approach from either the Gulf of Mexico or the Atlantic Ocean, and often decay well before reaching Charleston. They are likely to occur through much of the hurricane season, whereas extreme events are most common during a short period toward the end of August. There is no significant difference between common and extreme translational velocity at landfall. This study demonstrates the opportunity that synthetic tracks provide for understanding the rarest hurricanes and provides initial insight into those affecting Charleston.
The Relationship between Elevation Roughness and Tornado Activity: A Spatial Statistical Model Fit to Data from the Central Great Plains
Authors: Elsner James B. , Fricker Tyler , Widen Holly M. , Castillo Carla M. , Humphreys John , Jung Jihoon , Rahman Shoumik , Richard Amanda , Jagger Thomas H. , Bhatrasataponkul Tachanat , Gredzens Christian , Dixon P. Grady 
Published: February 2016

AbstractThe statistical relationship between elevation roughness and tornado activity is quantified using a spatial model that controls for the effect of population on the availability of reports. Across a large portion of the central Great Plains the model shows that areas with uniform elevation tend to have more tornadoes on average than areas with variable elevation. The effect amounts to a 2.3% [(1.6%, 3.0%) = 95% credible interval] increase in the rate of a tornado occurrence per meter of decrease in elevation roughness, defined as the highest minus the lowest elevation locally. The effect remains unchanged if the model is fit to the data starting with the year 1995. The effect strengthens for the set of intense tornadoes and is stronger using an alternative definition of roughness. The elevation-roughness effect appears to be strongest over Kansas, but it is statistically significant over a broad domain that extends from Texas to South Dakota. The research is important for developing a local climatological description of tornado occurrence rates across the tornado-prone region of the Great Plains.
Mixed-Mode Oscillations of El Niño–Southern Oscillation
Authors: Roberts Andrew , Guckenheimer John , Widiasih Esther , Timmermann Axel , Jones Christopher K. R. T. 
Published: February 2016

Abstract
Very strong El Niño events occur sporadically every 10–20 yr. The origin of this bursting behavior still remains elusive. Using a simplified three-dimensional dynamical model of the tropical Pacific climate system, which captures El Niño–Southern Oscillation (ENSO) combined with recently developed mathematical tools for fast–slow systems, the authors show that decadal ENSO bursting behavior can be explained as a mixed-mode oscillation (MMO), which also predicts a critical threshold for rapid amplitude growth. It is hypothesized that the MMO dynamics of the low-dimensional climate model can be linked to a saddle-focus equilibrium point, which mimics a tropical Pacific Ocean state without ocean circulation.