bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zoophytophagous mirids provide pest control by inducing direct defences, antixenosis and attraction to parasitoids in sweet pepper plants
Authors: Bouagga Sarra , Urbaneja Alberto , Rambla José L , Flors Víctor , Granell Antonio , Jaques Josep A , Pérez‐Hedo Meritxell 
Published: December 2017

AbstractBACKGROUNDIn addition to their services as predators, mirid predators are able to induce plant defences by phytophagy. However, whether this induction occurs in sweet pepper and whether it could be an additional benefit to their role as a biological control agent in this crop remain unknown. Here, these questions were investigated in two model insects, the mirids Nesidiocoris tenuis and Macrolophus pygmaeus.RESULTSPlant feeding behaviour was observed in both N. tenuis and M. pygmaeus on sweet pepper and occupied 33% and 14% of total time spent on the plant, respectively. The punctures caused by mirid plant feeding induced the release of a blend of volatile organic compounds (VOCs) which repelled the herbivore pests Frankliniella occidentalis and Bemisia tabaci and attracted the whitefly parasitoid Encarsia formosa. The repellent effect on B. tabaci was observed for at least 7 days after initial exposure of the plant to N. tenuis, and attraction of E. formosa remained functional for 14 days.CONCLUSIONPlant defences induced by the feeding of mirid predators, their subsequent effects on the behaviour of both pests and natural enemies, and the persistence of these observed effects open the door to new control strategies in the sweet pepper crop. Further application of this research is discussed, such as the vaccination of plants by zoophytophagous mirids in the nursery before transplantation. © 2017 Society of Chemical Industry
Development of a Bioanode for Microbial Fuel Cells Based on the Combination of a MWCNT‐Au‐Pt Hybrid Nanomaterial, an Osmium Redox Polymer and Gluconobacter oxydans DSM 2343 Cells
Authors: Aslan Sema , Ó Conghaile Peter , Leech Dónal , Gorton Lo , Timur Suna , Anik Ulku 
Published: December 2017

AbstractIn this work, a carbon felt electrode (CFE) was modified with a multiwalled carbon nanotube‐gold‐platinum (MWCNT−Au‐Pt) hybrid nanomaterial and integrated with an osmium redox polymer (OsRP, [Os(2, 2’‐bipyridine)2(poly‐vinylimidazole)10Cl]Cl) and Gluconobacter oxydans DSM 2343 (G. oxydans) cells. The developed electrode was used as the bioanode in a 5.0 mM K3Fe(CN)6 mediator containing phosphate buffer (pH 6.5) anolyte and combined with a Pt wire cathode in phosphoric acid medium (pH 3.5). As a result, a two chamber microbial fuel cell (MFC) was formed, in which an activated Nafion membrane was used as a proton exchange membrane. The OsRP/G.oxydans/MWCNT−Au‐Pt/CFE based bioanode was electrochemically examined in differently deoxygenated bioanode chambers and additionally the amounts of hybrid nanomaterial and OsRP were optimized. In terms of MFC characteristics, it was found that an anaerobic OsRP/G.oxydans/MWCNT−Au‐Pt/CFE bioanode based MFC had a maximum power density of 32.1 mW m−2 (at 90 mV), a maximum current density of 1032 mA m−2 and a charge transfer efficiency (E%) value of 22.30 (open circuit potential 180 mV).
Evaluation of Language Predictors of Main Concept Production in Spanish/English Bilingual Discourse Using Nicholas and Brookshire Stimuli
Authors: Rivera Ana , Hirst Jonathan , Edmonds Lisa A. 
Published: December 2017

PurposeA conceptual framework of bilingual aphasia assessment requires an understanding of the variables that influence discourse in bilingual speakers. This study aimed to determine predictors of main concept (MC) production, a measure of discourse completeness, as well as the effect of language dominance on MCs.MethodThe Nicholas and Brookshire (1993) picture stimuli were used to elicit English and Spanish discourse in 83 young bilinguals. Participant-reported variables (e.g., proficiency self-ratings) and measured language variables (e.g., correct information units [CIUs] in discourse) were entered into regressions to determine potential MC predictors. A repeated-measures analysis of variance evaluated MCs within and across dominance groups categorized by speaking self-ratings.ResultsMeasured language variables (number of CIUs, naming accuracy) were most predictive of MCs. The participant-reported variable most associated with MC production was self-rating of speaking proficiency. Spanish- and English-dominant groups produced more MCs in their dominant language; the balanced group produced more English MCs. Between-groups differences were observed.ConclusionsTwo measures related to lexical retrieval (CIUs and naming) were most predictive of MC production across languages. Participant ratings of speaking proficiency were also highly correlated to MCs. They also accurately reflected dominance, though balanced bilinguals overestimated their Spanish abilities.Supplemental Materialhttps://doi.org/10.23641/asha.5708605
Improving Program NCLEX Pass Rates
Authors: Libner Joan , Kubala Sandra 
Published: December 2017

Abstract

AIM
This article describes the response of the Illinois Board of Nursing to an escalating number of prelicensure nursing programs with low National Council Licensure Examination (NCLEX) pass rates. The response aligns with stipulations of the Illinois Nurse Practice Act and best practices.

BACKGROUND
NCLEX success is crucial to launching the careers of nursing graduates and to maintaining approval status of prelicensure programs by state regulatory bodies. Boards strive to guide programs with low pass rates fairly and consistently.

METHOD
The Illinois Board of Nursing created a tool and process addressing curriculum and resources, faculty, students, and administrative support in a programmatic approach to improving pass rates.

RESULTS
Initial outcomes were positive. Anecdotal evidence of programs in good standing also confirmed the tool’s value as a resource to promoting graduate success.

CONCLUSION
A programmatic approach can provide guidance for boards of nursing to address low NCLEX pass rates in a consistent evidence-based manner.
Essential Professional Behaviors of Nursing Students and New Nurses: Hospital Nurse Leader Perspectives Survey
Authors: Sortedahl Charlotte , Persinger Sara , Sobtzak Kathryn , Farrell Brooke , Jaeger Nicholas 
Published: December 2017

Abstract

AIM
This two-part study was conducted to determine which professional behaviors hospital nurse leaders believe are essential for nursing students to learn in the classroom.

BACKGROUND
Nursing students need to be educated to lead high-quality care in complex health care environments. Little is known regarding the professional behaviors deemed essential for novice nurses.

METHOD
Hospital leaders were surveyed (n = 221) using the Hospital Nurse Leader Perspectives survey. This survey, developed from interviews, includes 41 items in change, communication, conflict, leadership, and self-awareness.

RESULTS
The highest-ranked category was communication (n = 159, 72 percent), followed by self-awareness (n = 32, 14.4 percent). The highest items in each category were patient communication, prioritization, expect change, learning from failure, and conflict resolution.

CONCLUSION
The results provide practical information to inform curricula and prepare leaders.
Late-Onset Inflammatory Response to Hyaluronic Acid Dermal Fillers
Authors: Bhojani-Lynch Tahera 
Published: December 2017

Objective:Even though injectable hyaluronic acid (HA)–based fillers are considered safe, rare complications, such as late-onset inflammatory reactions have been reported. Possible causes and effective treatments have not been formally described, so this work aims to discuss these and offer a formal protocol for treatment.Methods:This article presents 5 clinical cases of late-onset inflammatory response occurring at least 3 months after uneventful injection of HA dermal filler.Results:Inflammation appeared spontaneously, usually 4–5 months after the last injection, but in 1 patient, almost 14 months later. One patient was injected at the same time with fillers manufactured by 2 different technologies. In this case, all areas treated with the same filler showed diffuse swelling of inflammatory nature, whereas the lips, treated with the second filler brand, remained unaffected. Four patients reported a flu-like illness or gastrointestinal upset a few days before the onset of dermal filler inflammation.Conclusion:Late-onset inflammatory reactions to HA fillers may be self-limiting but are easily and rapidly treatable with oral steroids, and with hyaluronidase in the case of lumps. It is likely these reactions are due to a Type IV delayed hypersensitivity response. Delayed inflammation associated with HA fillers is nonbrand specific. However, the case where 2 different brands were injected during the same session, but only 1 brand triggered a hypersensitivity reaction, suggests that the technology used in the manufacturing process, and the subsequent differing products of degradation, may have an influence on potential allergic reactions to HA fillers.
Return to Sport After Arthroscopic Autologous Matrix-Induced Chondrogenesis for Patients With Osteochondral Lesion of the Talus
Authors: D'Ambrosi Riccardo , Villafañe Jorge H. , Indino Cristian , Liuni Federico M. , Berjano Pedro , Usuelli Federico G. 
Published: December 2017

Objective:
To determine the rate of return of patients to sport after arthroscopic autologous matrix-induced chondrogenesis (AT-AMIC) for outcomes 2 years after surgery.

Design:
Retrospective observational cross-sectional study.

Setting:
C.A.S.C.O.—Foot and Ankle Unit, Istituto Ortopedico Galeazzi, Milan, Italy.

Patients and Intervention:
Twenty-six consecutive patients, 65.4% male (mean ± SD age: 33.7 ± 11.0 years), that underwent AT-AMIC procedure between 2012 and 2015 were selected retrospectively. From this population, only sporting patients at amateur's level were included. Arthroscopic autologous matrix-induced chondrogenesis was proposed in patients with pain and persistent disability.

Main Outcome Measures:
All patients were assessed with the American Orthopaedic Foot and Ankle Score (AOFAS), physical component score of the 12-Item Short Form Health Survey (SF-12), Halasi ankle activity score, and University of California, Los Angeles (UCLA) activity scale preoperatively and at 24 months postoperatively.

Results:
Overall, 80.8% of the patient group returned to the same preinjury sport. The mean follow-up was 42.6 ± 10.9 months (range from 25 to 62 months). Significant differences were observed with reference to AOFAS, SF-12, Halasi, and UCLA scores at the last follow-up in patients who had undergone AT-AMIC (all, P < 0.001).

Conclusions:
A high percentage of patients return to their preinjury sport after AT-AMIC surgery.
High-Risk Human Papillomavirus Detection in Urine Samples From a Referral Population With Cervical Biopsy-Proven High-Grade Lesions
Authors: Lorenzi Adriana T. , Fregnani José Humberto T. , Dockter Janel , Fitzgerald Kerry , Strohecker Elizabeth , Eaton Barbara , Vibat Cecile Rose T. , Erlander Mark G. , Scapulatempo-Neto Cristovam , Smith Jennifer S. , Longatto-Filho Adhemar 
Published: December 2017

Objective
The aim of the study was to evaluate the performance of the HPV-HR test to detect high-risk human papillomavirus (HPV) in urine samples in comparison with a commercial molecular HPV test.

Materials and Methods
This is a prospective study, in which 350 patients diagnosed previously with cervical intraepithelial neoplasia (CIN) grade 2 or higher were enrolled. Urine and cervical specimens were collected. Urine was tested with the HPV-HR test and cervical specimens were tested with the Cobas.

Results
Of the 336 evaluable patients, there were 271 cases of CIN 2+, of which 202 were CIN 3+ and the remaining 65 patients were less than CIN 2. Positivity was 77.1% (95% confidence interval [CI] = 72.5–81.5) for the urine samples and 83.6% (95% CI = 79.6–87.6) for the cervical samples. Agreement between cervical and urine samples for HPV detection was 79.8% (κ = 0.363; 95% CI = 0.243–0.484). Sensitivity for CIN 2+ was 83.4% (95% CI = 78.4–87.6) for urine and 90.8% (95% CI = 86.7–92.9) for cervical samples. The sensitivity for CIN 3+ was 85.6% (95% CI = 80.0–90.2) for urine and 92.6% (95% CI = 88.0–95.8) for cervical samples. Specificity for worse than CIN 2 was 50.8% (95% CI = 33.7–59.0) and 46.2% (95% CI = 33.7–59.0) for urine and cervical samples, respectively.

Conclusions
Although these results demonstrated slightly higher detection rates for HR-HPV and clinical sensitivity in cervical samples than in urine, when compared with histological diagnoses, urine sampling is a viable alternative to access women who do not participate in routine screening programs.
A Cross-Sectional Review of Cervical Cancer Messages on Twitter During Cervical Cancer Awareness Month
Authors: Teoh Deanna , Shaikh Rida , Vogel Rachel Isaksson , Zoellner Taylor , Carson Linda , Kulasingam Shalini , Lou Emil 
Published: December 2017

Objectives
The objectives of this study were to quantify personal stories about cervical cancer and to determine the proportion and sentiment (positive vs negative) of messages (“tweets”) that discussed cervical cancer prevention strategies on Twitter.

Methods
This study was a cross-sectional Twitter review of English-language top tweets about cervical cancer during the Cervical Cancer Awareness month, January 2016. Theme categories were identified, and tweets were independently coded by 2 reviewers; discrepancies in coding were resolved by a third reviewer. Descriptive statistical analyses were performed.

Results
During January 2016, approximately 348 top tweets about cervical cancer were identified. Professional health organizations produced 20.7% of tweets, and individuals identifying themselves as health-care professionals contributed an additional 4%. In addition to the tweet, 45.1% attached a photo or video; 54.6% included links to a larger article. Only 11.2% of tweets included personal stories from cervical cancer patients. Among the top tweets, 70.3% were focused on prevention through screening and/or HPV vaccination, with 97.4% recommending such practices. A substantial proportion of the Twitter traffic (24.7%) referenced the #SmearForSmear campaign by the patient-advocate organization Jo’s Cervical Cancer Trust, based in the United Kingdom.

Conclusions
Analysis of top tweets during the cervical cancer awareness month showed that, although personal stories about cervical cancer were rare, cervical cancer prevention was a popular topic during the cervical cancer awareness month. This was largely driven by a picture-based twitter campaign from a single advocacy organization.
Toll-Like Receptor Signaling Contributes to Proinflammatory Mediator Production in Localized Provoked Vulvodynia
Authors: Falsetta Megan L. , Foster David C. , Woeller Collynn F. , Pollock Stephen J. , Bonham Adrienne D. , Piekna-Przybylska Dorota , Maggirwar Sanjay B. , Haidaris Constantine G. , Phipps Richard P. 
Published: December 2017

Objectives
Localized provoked vulvodynia (LPV) afflicts approximately 8% of women in the United States and represents a huge financial, physical, and psychological burden. Women with LPV experience intense pain localized to the vulvar vestibule (area immediately surrounding vaginal opening). We have identified mechanisms involved in the development of LPV whereby vulvar fibroblasts respond to proinflammatory stimuli to perpetuate an inflammatory response that causes pain. However, these mechanisms are not fully elucidated. Therefore, we explored the role of toll-like receptors (TLRs), a class of innate immune receptors that rapidly respond to microbial assaults.

Materials and Methods
To determine whether TLRs are expressed by vulvar fibroblasts and whether these contribute to proinflammatory mediator production and pain in LPV, we examined TLR expression and innate immune responses in fibroblasts derived from painful vestibular regions compared with nonpainful external vulvar regions.

Results
Human vulvar fibroblasts express functional TLRs that trigger production of inflammatory mediators associated with chronic pain. We focused on the TLR-7–imiquimod proinflammatory interaction, because imiquimod, a ligand of TLR-7, may exacerbate pain in women during treatment of human papillomavirus–associated disease.

Conclusions
Human vulvar fibroblasts express a broad spectrum of TLRs (a new finding). A significantly higher TLR-mediated proinflammatory response was observed in LPV case vestibular fibroblasts, and with respect to the imiquimod-TLR 7 interaction, development of chronic vestibular pain and inflammation may be a possible sequelae of treatment of vulvar human papillomavirus–associated disease. Suppressing enhanced TLR-associated innate immune responses to a spectrum of pathogen-associated molecular patterns may represent a new/effective therapeutic approach for vulvodynia.
Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice
Authors: Roselló-Díez Alberto , Madisen Linda , Bastide Sébastien , Zeng Hongkui , Joyner Alexandra L. 
Published: December 2017

AbstractCatch-up growth after insults to growing organs is paramount to achieving robust body proportions. In fly larvae, local injury is followed by local and systemic compensatory mechanisms that allow damaged tissues to regain proportions with other tissues. In vertebrates, local catch-up growth has been described after transient reduction of bone growth, but the underlying cellular responses are controversial. We developed an approach to study catch-up growth in foetal mice by inducing mosaic expression of the cell cycle suppressor p21 in the cartilage cells (chondrocytes) that drive long bone elongation. By specifically targeting the left hindlimb, the right limb served as an internal control. Strikingly, left-right limb symmetry was not altered, revealing deployment of compensatory mechanisms. Above a certain threshold of insult, an orchestrated response was triggered involving local enhancement of bone growth and systemic growth reduction that ensured body proportions were maintained. The local response entailed hyper-proliferation of spared left-limb chondrocytes that was associated with reduced chondrocyte density. The systemic effect involved impaired placental IGF signalling and function, revealing bone-placenta communication. Thus, vertebrates, much like invertebrates, can mount coordinated local and systemic responses to developmental insults to ensure normal body proportions are maintained.
Predicting resistance of clinical Abl mutations to targeted kinase inhibitors using alchemical free-energy calculations
Authors: Hauser Kevin , Negron Christopher , Albanese Steven K. , Ray Soumya , Steinbrecher Thomas , Abel Robert , Chodera John D. , Wang Lingle 
Published: December 2017

AbstractThe therapeutic effect of targeted kinase inhibitors can be significantly reduced by intrinsic or acquired resistance mutations that modulate the affinity of the drug for the kinase. In cancer, the majority of missense mutations are rare, making it difficult to predict their impact on inhibitor affinity. This complicates the practice of precision medicine, pairing of patients with clinical trials, and development of next-generation inhibitors. Here, we examine the potential for alchemical free-energy calculations to predict how kinase mutations modulate inhibitor affinities to Abl, a major target in chronic myelogenous leukemia (CML). We find these calculations can achieve useful accuracy in predicting resistance for a set of eight FDA-approved kinase inhibitors across 144 clinically-identified point mutations, achieving a root mean square error in binding free energy changes ofkcal/mol (95% confidence interval) and correctly classifying mutations as resistant or susceptible withaccuracy. Since these calculations are fast on modern GPUs, this benchmark establishes the potential for physical modeling to collaboratively support the rapid assessment and anticipation of the potential for patient mutations to affect drug potency in clinical applications.
Alignment-Free Approaches for Predicting Novel Nuclear Mitochondrial Segments (NUMTs) in the Human Genome
Authors: Li Wentian , Freudenberg Jerome , Freudenberg Jan 
Published: December 2017

AbstractThe nuclear human genome harbors sequences of mitochondrial origin, indicating an ancestral transfer of DNA from the mitogenome. Several Nuclear Mitochondrial Segments (NUMTs) have been detected by alignment-based sequence similarity search, as implemented in the Basic Local Alignment Search Tool (BLAST). Identifying NUMTs is important for the comprehensive annotation and understanding of the human genome. Here we explore the possibility of detecting NUMTs in the human genome by alignment-free sequence similarity search, such as k-mers (k-tuples, k-grams, oligos of length k) distributions. We find that when k=6 or larger, the k-mer approach and BLAST search produce almost identical results, e.g., detect the same set of NUMTs longer than 3kb. However, when k=5 or k=4, certain signals are only detected by the alignment-free approach, and these may indicate yet unrecognized, and potentially more ancestral NUMTs. We introduce a “Manhattan plot” style representation of NUMT predictions across the genome, which are calculated based on the reciprocal of the Jensen-Shannon divergence between the nuclear and mitochondrial k-mer frequencies. The further inspection of the k-mer-based NUMT predictions however shows that most of them contain long-terminal-repeat (LTR) annotations, whereas BLAST-based NUMT predictions do not. Thus, similarity of the mitogenome to LTR sequences is recognized, which we validate by finding the mitochondrial k-mer distribution closer to those for transposable sequences and specifically, close to some types of LTR.
Association between UDP‐glucuronosyltransferase 2B7 tagSNPs and breast cancer risk in Chinese females
Authors: He Bao‐Xia , Qiao Bin , Lam Alfred King‐Yin , Zhao Xiu‐Li , Zhang Wen‐Zhou , Liu Hui 
Published: December 2017

SummaryThis retrospective study was performed to evaluate the association between the UGT2B7 tagSNPs (rs12233719, rs4356975, rs7435335 and rs7441774) and breast cancer in Chinese females. Blood samples were collected from 672 patients with breast cancer and 670 healthy controls for DNA extraction. Matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) was used to analyze UGT2B7 polymorphisms. Dual‐luciferase reporter assays were further performed to investigate the regulatory function of UGT2B7 tagSNPs. The frequency of rs7441774 G allele in the breast cancer cases was statistically significantly higher than in the controls (0.412 vs 0.358, P = .006; odds ratio [OR] = 1.27, 95% CI = 1.08‐1.48). After adjusting for conventional risk factors, individuals with the GG genotype had a higher breast cancer risk than those with the AA genotype (adjusted OR = 1.63, 95% CI = 1.18‐2.26; P = .008). The GCGG haplotype of UGT2B7 was also associated with breast cancer (OR = 1.22, 95% CI = 1.04‐1.45; P = .027). Meanwhile, the rs7441774 G allele could significantly decrease the transcriptional activity of the UGT2B7 gene. This study indicates that UGT2B7 polymorphisms may play a crucial role in the occurrence and development of breast cancer in the Han Chinese population.