bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of Neoantigen Landscape during Immune Checkpoint Blockade in Non–Small Cell Lung Cancer
Authors: Anagnostou Valsamo , Smith Kellie N. , Forde Patrick M. , Niknafs Noushin , Bhattacharya Rohit , White James , Zhang Theresa , Adleff Vilmos , Phallen Jillian , Wali Neha , Hruban Carolyn , Guthrie Violeta B. , Rodgers Kristen , Naidoo Jarushka , Kang Hyunseok , Sharfman William , Georgiades Christos , Verde Franco , Illei Peter , Li Qing Kay , Gabrielson Edward , Brock Malcolm V. , Zahnow Cynthia A. , Baylin Stephen B. , Scharpf Robert B. , Brahmer Julie R. , Karchin Rachel , Pardoll Drew M. , Velculescu Victor E. 
Published: December 2016

AbstractImmune checkpoint inhibitors have shown significant therapeutic responses against tumors containing increased mutation-associated neoantigen load. We have examined the evolving landscape of tumor neoantigens during the emergence of acquired resistance in patients with non–small cell lung cancer after initial response to immune checkpoint blockade with anti–PD-1 or anti–PD-1/anti–CTLA-4 antibodies. Analyses of matched pretreatment and resistant tumors identified genomic changes resulting in loss of 7 to 18 putative mutation-associated neoantigens in resistant clones. Peptides generated from the eliminated neoantigens elicited clonal T-cell expansion in autologous T-cell cultures, suggesting that they generated functional immune responses. Neoantigen loss occurred through elimination of tumor subclones or through deletion of chromosomal regions containing truncal alterations, and was associated with changes in T-cell receptor clonality. These analyses provide insight into the dynamics of mutational landscapes during immune checkpoint blockade and have implications for the development of immune therapies that target tumor neoantigens.Significance: Acquired resistance to immune checkpoint therapy is being recognized more commonly. This work demonstrates for the first time that acquired resistance to immune checkpoint blockade can arise in association with the evolving landscape of mutations, some of which encode tumor neoantigens recognizable by T cells. These observations imply that widening the breadth of neoantigen reactivity may mitigate the development of acquired resistance. Cancer Discov; 7(3); 264–76. ©2017 AACR.See related commentary by Yang, p. 250.This article is highlighted in the In This Issue feature, p. 235
Relationship Between Distance and Change in Surface ECG Morphology During Pacemapping as a Guide to Ablation of Ventricular Arrhythmias
Authors: Li Anthony , Davis Joseph Samuel , Wierwille Jeremiah , Herold Keith , Morgan Dennis , Behr Elijah , Shorofsky Stephen , Saba Magdi 
Published: December 2016

Background—
Pacemapping is used to localize the exit site of ventricular arrhythmia. Although the relationship between distance and change in QRS morphology is its basis, this relationship has not been systematically quantified.

Methods and Results—

Patients (n=68) undergoing ventricular arrhythmia ablation between March 2012 and July 2013 were recruited. Pacemapping was targeted to areas of voltage >0.5 mV. Linear mixed-effects models were constructed of distance against morphology difference measured by the root mean square error sum across all 12 ECG leads (E12). Forty of 68 (58%) patients had structural heart disease, and 21/40 (53%) patients were ischemic. Nine hundred thirty-five pacing points were collected, generating 6219 pacing site pair combinations (3087 [50%] ventricular bodies, 756 [12%] outflow tract, and 162 [3%] epicardial). In multivariable analysis, increase in E12 was predicted by increasing distance (0.07 per mm; 95% confidence interval 0.07–0.08;
P
<0.001). Compared with the left ventricle, E12 values were lower in the right ventricle (
P
=0.037) and left ventricular outflow tract (
P
<0.001) and higher in left ventricle–right ventricle pairs (
P
=0.021) and left ventricular epicardium (
P
=0.08). There was no difference in E12 in the right ventricular outflow tract compared with the right–left ventricular outflow tract (
P
=0.75) pairs. Structural heart disease or inadvertent pacing in scar was not associated with changes in E12; however, the presence of latency and split potentials were associated with higher and lower E12 values, respectively (
P
<0.001).

Conclusions—
A robust positive relationship exists between distance and QRS morphological change when restricting pacing points to areas of voltage >0.5 mV. Significant differences in the spatial resolution of pacemapping exist within the heart.
Neurological Injury and Cerebral Blood Flow in Single Ventricles Throughout Staged Surgical Reconstruction
Authors: Fogel Mark A. , Li Christine , Elci Okan U. , Pawlowski Tom , Schwab Peter J. , Wilson Felice , Nicolson Susan C. , Montenegro Lisa M. , Diaz Laura , Spray Thomas L. , Gaynor J. William , Fuller Stephanie , Mascio Christopher , Keller Marc S. , Harris Matthew A. , Whitehead Kevin K. , Bethel Jim , Vossough Arastoo , Licht Daniel J. 
Published: December 2016

Background:
Patients with a single ventricle experience a high rate of brain injury and adverse neurodevelopmental outcome; however, the incidence of brain abnormalities throughout surgical reconstruction and their relationship with cerebral blood flow, oxygen delivery, and carbon dioxide reactivity remain unknown.

Methods:
Patients with a single ventricle were studied with magnetic resonance imaging scans immediately prior to bidirectional Glenn (pre-BDG), before Fontan (BDG), and then 3 to 9 months after Fontan reconstruction.

Results:

One hundred sixty-eight consecutive subjects recruited into the project underwent 235 scans: 63 pre-BDG (mean age, 4.8±1.7 months), 118 BDG (2.9±1.4 years), and 54 after Fontan (2.4±1.0 years). Nonacute ischemic white matter changes on T2-weighted imaging, focal tissue loss, and ventriculomegaly were all more commonly detected in BDG and Fontan compared with pre-BDG patients (
P
<0.05). BDG patients had significantly higher cerebral blood flow than did Fontan patients. The odds of discovering brain injury with adjustment for surgical stage as well as ≥2 coexisting lesions within a patient decreased (63%–75% and 44%, respectively) with increasing amount of cerebral blood flow (
P
<0.05). In general, there was no association of oxygen delivery (except for ventriculomegaly in the BDG group) or carbon dioxide reactivity with neurological injury.

Conclusions:

Significant brain abnormalities are commonly present in patients with a single ventricle, and detection of these lesions increases as children progress through staged surgical reconstruction, with multiple coexisting lesions more common earlier than later. In addition, this study demonstrated that BDG patients had greater cerebral blood flow than did Fontan patients and that an inverse association exists of various indexes of cerebral blood flow with these brain lesions. However, CO
2
reactivity and oxygen delivery (with 1 exception) were not associated with brain lesion development.

Clinical Trial Registration:

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02135081.
Natio Made Visible: The Hungarian Political Community in Illustrated Books (ca. 1350–1700)
Authors: Mroziewicz Karolina 
Published: December 2016

Natio Made Visible: The Hungarian Political Community in Illustrated Books (ca. 1350–1700)The main objective of this paper is to examine the understanding of the natio Hungarica, as it emerges from the texts and images of a number of richly illustrated Hungarian books. The Chronicon pictum (ca. 1358), János Thuróczy’s Chronica Hungarorum (Brno, Augsburg, 1488), Mausoleum regum et Ungariae ducum (Nuremberg, 1664), Trophaeum domus Estorasianae (Vienna, 1700) and Clarissimorum Hungariae heroum icones (Vienna, 1652) served as points of reference for the discussion on the ways in which the Hungarian political community wanted to be and was perceived prior to its eighteenth- and nineteenthcentury transformation into a modern nation. The study encompasses the formative period of Hungarian illustrated books that contributed to the formulation of the national imagery in Hungary, based on the ethno-genetic myths, memories of shared ancestry and collective past, cultural values, legal code, customs and models of conduct, modes of self-display, and, last but not least, on the imagery of the homeland. The three-and-a-half-century chronological scope of the study has made it possible to trace the major changes which the concept of natio Hungarica underwent between mid-fourteenth and seventeenth centuries. Unaoczniona Nacja Węgierska wspólnota polityczna w książkach ilustrowanych (ca. 1350 – 1700)Głównym celem artykułu było zbadanie rozumienia pojęcia natio Hungarica, jakie wyłania się z tekstów i obrazów węgierskich książek ilustrowanych. Chronicon pictum (ca. 1358), Chronica Hungarorum Jánosa Thuróczy’ego (Brno, Augsburg, 1488), Mausoleum regum et Ungariae ducum (Norymberga, 1664), Trophaeum domus Estorasianae (Wiedeń, 1700) oraz Clarissimorum Hungariae heroum icones (Wiedeń, 1652) stanowiły punkt wyjścia do analizy wyobrażeń, jakie wspólnota polityczna miała na swój temat oraz jakie starano się jej narzucić przed erą narodowościowotwórczych procesów osiemnastego i dziewiętnastego wieku. Artykuł koncentruje się na formatywnym okresie w dziejach ilustrowanej książki węgierskiej, który przyczynił się do powstania wyobrażeń narodowych opartych na micie etnogenezy, pamięci o przodkach i wspólnej historii, wartościach kulturowych, prawie, zwyczajach, modelach zachowania i autoprezentacji oraz wyobrażeniu ojczyzny. Szeroki, obejmujący trzy i pół wieku zakres chronologiczny studium umożliwił prześledzenie najważniejszych przesunięć znaczeniowych, jakie zachodziły w rozumieniu natio Hungarica między połową czternastego stulecia a siedemnastym wiekiem.
The Buryat-Mongols’ Way of Being and Their National Image of the World
Authors: Boldonova Irina 
Published: December 2016

The Buryat-Mongols’ Way of Being and Their National Image of the WorldThe article focuses on the comparison of two main concepts in the national image of the world of the Buryat-Mongols as it applies to their way of being: the Man of the Steppes and the Man of Water and the Woods. The research is based on the theory of the well-known Russian scholar Georgiĭ Gachev, who connects types of landscape and natural environment to national images of the world. Dwelling around Lake Baikal on the one hand, and at flat steppe territories on the other hand is reflected in two alternative ways of living, as well as images of world and forms of imagination. The author of the article analyzes the two variants of identity, which have always been under the influence of certain geographical and climate factors, economic activities, as well as cultural and historic traditions of various Buryat-Mongol ethnic subgroups. Buriacko-mongolska droga życia i narodowy obraz świataArtykuł jest poświęcony komparatystycznej analizie dwóch podstawowych konceptów (hipostaz) buriacko-mongolskiego narodowego obrazu świata: człowiekowi stepów i człowiekowi wody i lasu. Analiza opiera się na teorii znanego rosyjskiego badacza Gieorgija Gaczewa, który postuluje istnienie wzajemnego oddziaływania między obrazami natury i narodowym obrazem świata. Życie wokół jeziora Bajkał z jednej strony i praca w bezkresnym stepie z drugiej znajdują wyraz w tych dwóch podstawowych formach istnienia, światopoglądach i formach wyobraźni. Autorka artykułu analizuje te dwie odmiany tożsamości, które podlegają wpływowi ze strony określonych czynników geograficznych i klimatycznych, aktywności ekonomicznej oraz historyczno-kulturowej tradycji różnych buriacko-mongolskich podgrup etnicznych.
Not Just For Kicks
Authors: Usakiewicz Krzysztof 
Published: December 2016

Not Just For KicksThe match-up between Makabi and Inter did not attract many spectators. The weather was likely the only factor at play, since that Saturday in November was extremely nasty. That was because the game was held not in Haifa or even Milan, but in the Warsaw district of Mokotów. To be precise, on a small but well-kept field lined with artificial turf in the so-called Jordan’s Garden. The game, lasting fifty minutes including the break, was not especially fierce, and ended with Inter’s confident victory 5–1. Esej, który uzyskał wyróżnienie (drugie miejsce) w europejskim konkursie młodych badaczy (the Young Academies) w 2014 roku.
The Third Edition of the Inka Brodzka-Wald Award
Authors: Sujecka Jolanta 
Published: December 2016

The Third Edition of the Inka Brodzka-Wald AwardOn 16 June 2015, the Academy for the Development of Philanthropy in Poland and the Adam Mickiewicz Literary Society announced the winners of the third edition of the Inka Brodzka-Wald Award for doctoral dissertations in the humanities. The competition was open for theses which concerned present issues and were defended in 2014. Komunikat o rozstrzygnięciu trzeciej edycji Nagrody im. Inki Brodzkiej-Wald za rok 2014.
From the Discipline of the Whole to the Art of Concentration: Revisions of the Eastern and Central European Avant-Gardes: Review
Authors: Boruszkowska Iwona 
Published: December 2016

From the Discipline of the Whole to the Art of Concentration: Revisions of the Eastern and Central European Avant-Gardes: ReviewA review of two recent volumes concerning the idea of Central-European avant-garde: Awangarda Środkowej i Wschodniej Europy – Innowacja czy naśladownictwo? Interpretacje, ed. Michalina Kmiecik, Małgorzata Szumna, Wydawnictwo Uniwersytetu Jagiellońskiego, Kraków 2015, 355 pp.; Głuchy brudnopis: Antologia manifestów awangardy Europy Środkowej, ed. Jakub Kornhauser, Kinga Siewior, Wydawnictwo Uniwersytetu Jagiellońskiego, Kraków 2015, 578 pp. Od dyscypliny całości do sztuki koncentracji: rewizje wchodnio- i środkowoeuropejskiej awangardy; recenzjaRecenzja dwóch niedawno opublikowanych tomów poświęconych środkowoeuropejskiej awangardzie: Awangarda Środkowej i Wschodniej Europy – Innowacja czy naśladownictwo? Interpretacje, red. Michalina Kmiecik, Małgorzata Szumna, Wydawnictwo Uniwersytetu Jagiellońskiego, Kraków 2015, 355 s., oraz Głuchy brudnopis: Antologia manifestów awangardy Europy Środkowej, red. Jakub Kornhauser, Kinga Siewior, Wydawnictwo Uniwersytetu Jagiellońskiego, Kraków 2015, 578 s.
Spatiotemporal Assessment of Drought Related to Soybean Production and Sensitivity Analysis in Northeast China
Authors: Yang XiaoJuan , Liu Yuan , Bai Wei , Liu BuChun 
Published: December 2016

AbstractDrought is a typical disaster in the main soybean production area of northeast China. The spatiotemporal variations of drought related to soybean production based on a crop water deficit index (CWDI) and sensitivity to meteorological variables were investigated in northeast China using daily meteorological data from 87 weather stations from 1981 to 2010. Statistical analysis revealed that precipitation could not meet the water demands of soybeans during the seedling–branching, filling, and maturing stages, and excessive drought occurred more often in northeast China. The Mann–Kendall test indicated that the soybean CWDI significantly increased during the filling stage. Kriging spatial analysis showed that the most drought-prone area was located in the west of northeast China. Explanations for the spatiotemporal variations of the drought for soybean production were explored in terms of meteorological variables. Statistical analysis showed that the crop evapotranspiration, air temperature, wind speed, and number of sunshine hours were significantly higher and the precipitation and relative humidity were significantly lower in the drought-prone area than in the dry area less prone to droughts. An explored method of sensitive analysis quantitatively revealed that precipitation and humidity negatively affected the CWDI, whereas temperature, wind speed, and number of sunshine hours positively affected the CWDI. The CWDI was most sensitive to precipitation. These results not only provide valuable information for soybean planning and management but also produce important background and physical evidence for the influence of climate on the drought related to soybean production in northeast China.
Structure and Motion of Severe-Wind-Producing Mesoscale Convective Systems and Derechos in Relation to the Mean Wind
Authors: Campbell Matthew A. , Cohen Ariel E. , Coniglio Michael C. , Dean Andrew R. , Corfidi Stephen F. , Corfidi Sarah J. , Mead Corey M. 
Published: December 2016

Abstract
The goal of this study is to document differences in the convective structure and motion of long-track, severe-wind-producing MCSs from short-track severe-wind-producing MCSs in relation to the mean wind. An ancillary goal is to determine if these differences are large enough that some criterion for MCS motion relative to the mean wind could be used in future definitions of “derechos.” Results confirm past investigations that well-organized MCSs, including those that produce derechos, tend to move faster than the mean wind, exhibiting a significantly larger degree of propagation (component of MCS motion in addition to the component contributed by the mean flow). Furthermore, well-organized systems that produce shorter-track swaths of damaging winds likewise tend to move faster than the mean wind with a significant propagation component along the mean wind. Therefore, propagation in the direction of the mean wind is not necessarily a characteristic that can be used to distinguish derechos from nonderechos. However, there is some indication that long-track damaging wind events that occur without large-scale or persistent bow echoes and mesoscale convective vortices (MCVs) require a strong propagation component along the mean wind direction to become long lived. Overall, however, there does not appear to be enough separation in the motion characteristics among the MCS types to warrant the inclusion of a mean-wind criterion into the definition of a derecho at this time.
Ibrutinib inhibits pre-BCR+ B-cell acute lymphoblastic leukemia progression by targeting BTK and BLK
Authors: Kim Ekaterina , Hurtz Christian , Koehrer Stefan , Wang Zhiqiang , Balasubramanian Sriram , Chang Betty Y. , Müschen Markus , Davis R. Eric , Burger Jan A. 
Published: December 2016

Key PointsIn B-ALL, cells that express a functional pre-BCR ibrutinib abrogate leukemia cell growth in vitro and in vivo. Effects of ibrutinib in B-ALL not only are mediated through inhibition of BTK but also involve BLK inhibition.
PERCEPÇÃO DA CONDIÇÃO BUCAL DE PACIENTES ONCOLÓGICOS EM UMA UNIDADE DE ALTA COMPLEXIDADE EM FEIRA DE SANTANA- BA
Authors: Coelho Julita Maria Freitas , Santos Bruna Matos , Miranda Samilly Silva , Porto Edla Carvalho , Monção Maurício Mitsuo , Silva Caroline Santos , Bastos Michelly , Lima Larissa 
Published: December 2016

O câncer é um agravo de caráter multicausal e que envolve sofrimento psíquico e alterações comportamentais e bucais importantes, as quais podem comprometer a adesão e/ou sequência do tratamento. O objetivo desse estudo foi identificar a percepção do cuidado bucal (PCB) de pessoas com câncer, em presença ou não de transtornos psíquicos menores (TPM). Foi realizado um estudo transversal com 285 indivíduos atendidos em uma unidade de alta complexidade para tratamento da doença. Foram levantados dados socioeconômicos, de biologia humana, de percepção da saúde bucal, além de ter sido investigada a relação de TPM com a percepção da saúde bucal dos participantes. A maioria da amostra foi composta por pessoas idosas, com média de idade de aproximadamente 60,77±14,79 anos, do sexo feminino (60,70%) e de cor não branca (82,68%). Quanto a percepção de saúde bucal, 42,15% referiu visitas regulares ao dentista do grupo com TPM. Foi observado ainda, uma pior condição em cuidados bucais nos indivíduos com esta condição, embora não se tenha detectado diferenças estatisticamente significantes. Os resultados podem servir de subsídios para futuras investigações, visto que sinaliza que a presença de TPM pode prejudica os cuidados individuais com a saúde bucal e que provavelmente piores condições nos cuidados bucais podem interferir no tratamento do câncer.
Countering Violent Extremism: Islamophobia, the Department of Justice and American Islamic Organizations
Authors: Amber Michel  
Published: December 2016

In September 2014, United States Attorney General Eric Holder announced that a new counterterrorism initiative, Countering Violent Extremism (CVE), would be tested in three pilot cities across the US. Minneapolis, Minnesota is one of the three pilot cities for the new CVE initiative and is home to the largest Somali immigrant population in the world as well as a very large and diverse multi-ethnic Muslim community. Since 2008, when several young Somali-American Muslims left the US to participate in armed operations in Somalia, the community has suffered in an environment of extreme suspicion and distrust.
The surveillance of Muslim-Americans as a key component of American counterterrorism efforts has been the subject of both legal and academic analysis. Reports of spying, infiltration, and harassment have become commonplace in recent years. While these reports are often accompanied by challenges to the legality of the programs used to collect information, very little if any scholarship exists on how American Islamic organizations respond to this intense level of policing.
This research project examines the narrative generated by Muslim organizations in Minnesota, in response to heightened counterterrorism initiatives – particularly CVE – to assess the impact of counterterrorism programs on American Islamic organizations and to highlight the role of Islamophobia as it informs various aspects of such initiatives.
Initial findings suggest the presence of an accommodationist narrative among several organizations, but further investigation is required to explore the questions that raises. For example: How prevalent is that narrative? Is it indicative of a shift in organizational values? Is it an organizational strategy to appease law enforcement while allowing “genuine” work to continue unhampered?
Peripheral Inflammatory Biomarkers for Myocardial Infarction Risk: A Prospective Community-Based Study
Authors: Wu Zhijun , Huang Zhe , Jin Wei , Rimm Eric B , Lichtenstein Alice H , Kris-Etherton Penny M , Wu Shouling , Gao Xiang 
Published: December 2016

Abstract

BACKGROUND
Most previous studies regarding chronic inflammation and risk of myocardial infarction (MI) have lacked repeated measures of high-sensitivity C-reactive protein (hs-CRP) and/or white blood cell (WBC) count over time. We examined whether cumulative average and longitudinal changes in these biomarkers were associated with subsequent MI risk.

METHODS
In this prospective, community-based study, we included 82544 Chinese participants [66796 men and 15748 women; mean (SD) age 55.1 (9.86) y] without prior cardiovascular diseases or cancer at baseline (2006–2007). hs-CRP, WBC and other clinical covariates were assessed at baseline and every 2 years during follow-up.

RESULTS
During 6 years of follow-up (2006–2012), we documented 714 incident MI cases. Higher baseline and cumulative average concentrations of hs-CRP and/or WBC were consistently associated with increased risk of MI (Ptrend &lt;0.001 for both). Longitudinal increase in hs-CRP (Ptrend &lt;0.001), but not WBC, was also associated with a higher future risk of MI, after adjustment for their baseline values and other covariates. Each 1-mg/L increment per year in hs-CRP was associated with a 9.3% increase in risk for future MI [hazard ratio (HR) = 1.09, 95% CI, 1.03; 1.17]. Participants with high-grade inflammatory status (hs-CRP ≥10 mg/L and WBC ≥10 × 109/L) had a higher risk of MI occurring &lt;3 months after hs-CRP/WBC assessments vs those with hs-CRP &lt;0.5 mg/L and WBC &lt;5 × 109/L (HR = 6.64; 95% CI, 1.49–29.6), as compared with MI occurring ≥4 years (HR = 2.95; 95% CI, 0.90, 9.65).

CONCLUSIONS
Plasma hs-CRP concentration and WBC predicted MI risk. Longitudinal increase in hs-CRP was also associated with a higher risk of MI.