bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Implementation, and Analysis of an Assessment and Accreditation Model to Evaluate a Digital Competence Framework for Health Professionals: Mixed Methods Study
Authors: Saigí-Rubió Francesc , Romeu Teresa , Hernández Encuentra Eulàlia , Guitert Montse , Andrés Erik , Reixach Elisenda 
Published: October 2024

Background
Although digital health is essential for improving health care, its adoption remains slow due to the lack of literacy in this area. Therefore, it is crucial for health professionals to acquire digital skills and for a digital competence assessment and accreditation model to be implemented to make advances in this field.

Objective
This study had two objectives: (1) to create a specific map of digital competences for health professionals and (2) to define and test a digital competence assessment and accreditation model for health professionals.

Methods
We took an iterative mixed methods approach, which included a review of the gray literature and consultation with local experts. We used the arithmetic mean and SD in descriptive statistics, P values in hypothesis testing and subgroup comparisons, the greatest lower bound in test diagnosis, and the discrimination index in study instrument analysis.

Results
The assessment model designed in accordance with the competence content defined in the map of digital competences and based on scenarios had excellent internal consistency overall (greatest lower bound=0.91). Although most study participants (110/122, 90.2%) reported an intermediate self-perceived digital competence level, we found that the vast majority would not attain a level-2 Accreditation of Competence in Information and Communication Technologies.

Conclusions
Knowing the digital competence level of health professionals based on a defined competence framework should enable such professionals to be trained and updated to meet real needs in their specific professional contexts and, consequently, take full advantage of the potential of digital technologies. These results have informed the Health Plan for Catalonia 2021-2025, thus laying the foundations for creating and offering specific training to assess and certify the digital competence of such professionals.
Game-Based eHealth Interventions for the Reduction of Fatigue in People With Chronic Diseases: Systematic Review and Meta-Analysis
Authors: Warlo Leonie S , El Bardai Souraya , de Vries Andrica , van Veelen Marie-Lise , Moors Suzan , Rings Edmond HHM , Legerstee Jeroen S , Dierckx Bram 
Published: October 2024

Background
Fatigue is a common and debilitating side effect of chronic diseases, significantly impacting patients’ quality of life. While physical exercise and psychological treatments have been shown to reduce fatigue, patients often struggle with adherence to these interventions in clinical practice. Game-based eHealth interventions are believed to address adherence issues by making the intervention more accessible and engaging.

Objective
This study aims to compile empirical evidence on game-based eHealth interventions for fatigue in individuals with chronic diseases and to evaluate their effectiveness in alleviating fatigue.

Methods
A comprehensive literature search was performed across Embase, MEDLINE ALL, PsycINFO, Web of Science Core Collection, Cochrane Central Register of Controlled Trials, and Google Scholar in August 2021. Study characteristics and outcomes from the included studies were extracted, and a random-effects meta-analysis was conducted. Sensitivity and subgroup analyses were performed to identify sources of heterogeneity.

Results
Of 1742 studies identified, 17 were included in the meta-analysis. These studies covered 5 different chronic diseases: multiple sclerosis (n=10), cancer (n=3), renal disease (n=2), stroke (n=1), and Parkinson disease (n=1). All but 1 study used exergaming interventions. The meta-analysis revealed a significant moderate effect size in reducing fatigue favoring the experimental interventions (standardized mean difference [SMD] –0.65, 95% CI –1.09 to –0.21, P=.003) compared with control conditions consisting of conventional care and no care. However, heterogeneity was high (I2=85.87%). Subgroup analyses were conducted for the 2 most prevalent diseases. The effect size for the multiple sclerosis subgroup showed a trend in favor of eHealth interventions (SMD –0.47, 95% CI –0.95 to 0.01, P=.05, I2=63.10%), but was not significant for the cancer group (SMD 0.61, 95% CI –0.36 to 1.58, P=.22). Balance exercises appeared particularly effective in reducing fatigue (SMD –1.19, 95% CI –1.95 to –0.42, P=.002).

Conclusions
Game-based eHealth interventions appear effective in reducing fatigue in individuals with chronic diseases. Further research is needed to reinforce these findings and explore their impact on specific diseases. Additionally, there is a lack of investigation into interventions beyond exergaming within the field of game-based learning.
Determination of NPS Fertilizer Rate on Bread Wheat (Triticum Aestivum L.) in Yaya Gullele District of North Shewa Zone, Oromia, Ethiopia
Authors: Girma Dereje , Getahun Dejene , Tolosa Meron 
Published: October 2024

Inappropriate crop management practices are among the key elements that contributed to the low production of wheat. Moreover, the application of balanced fertilizers and nutrient requirements of the crop is the basis to produce more crop yield from the land under cultivation. Hence, a field experiment was conducted in the 2020 & 2021 main cropping season to determine the NPS fertilizer rate in relative to determined the P-critical and P-requirement factor for wheat and to estimate the economically feasible NPS fertilizer rate for higher yield of wheat in Yaya gulale District. Accordingly the result indicated that, plant height was not significantly (P > 0.05 ) influenced by the NPS fertilizer rate but spike length, biomass, and grain yield were highly significantly (P < 0.05) affected by the NPS fertilizer rate. The highest plant height (86.72cm), spike length (6.57cm), biomass yield (12163kg ha-1) and grain yield (3327 kg ha-1) of wheat were recorded by the application of 75% P-critical from NPS fertilizer rate supplemented with recommended Nitrogen whereas, the lowest value was recorded from the field without fertilizer which was significantly inferior to all other treatments. Furthermore, the economic analysis indicates that, application of NPS fertilizer at the rate of 75% P-critical in NPS fertilizer with recommended Nitrogen fertilizer (92 kg N ha-1) for the production of wheat was more economically beneficial for the district. In conclusion, farmers and other end users could be advised to use 75% PC from NPS fertilizer rate with recommended nitrogen for wheat production in the district and other areas having similar soil types and agro- ecology.
'Se pá' um condicional epistêmico!
Authors: Oliveira Roberta Pires de , Costa de Carvalho Bernar 
Published: October 2024

Este artigo tem como objetivo apresentar uma proposta para a semântica-pragmática da expressão ‘se pá’, característica da fala de comunidades mais jovens no Brasil. Em textos escritos, como whatsapp ou twitter, aparece grafada de maneiras distintas: ‘cepá', 'sepá', 'cpá' e etc.... Argumentamos que se trata de uma expressão composicional, em que o ‘se’ é a conjunção condicional e o ‘pá’ ocupa o lugar da sentença antecedente. Defendemos inicialmente que não estamos diante de um operador de possibilidade como ‘talvez’, mas de um condicional indicativo, já que não se combina com formas do verbo no subjuntivo. Mostramos, com base em Potts (2007), que o ‘pá’ carrega expressividade, veiculando a posição subjetiva do falante. Para a semântica, partimos da proposta de Kratzer (2012) para os condicionais em que o ‘se’ indica que a restrição da quantificação universal, que é implícita, é dada pelo antecedente. O antecedente está ocupado por ‘pá’, que veicula que as restrições são aquilo que é o curso normal dos eventos. A base modal são os mundos acessíveis a partir do mundo de avaliação, que são ordenados segundo a normalidade. O ‘pá’ é a proposição que resume as condições normais. Assim, o falante indica que se tudo for normal, o consequente se segue. Logo, ele não apenas está inclinado na direção do consequente, mas a expressividade da expressão veicula que o falante está emocionalmente inclinado nessa direção.
Conceptualización de “el yo” en las redes sociales. Afectos y relato entre lo verbal y no verbal
Authors: Picado Sánchez Manuel J. , Sibón Macarro Teresa-G. , Koffermann Marcia , Marques Gonçalves Bruna Caroline 
Published: October 2024

En el presente ensayo se procura reflexionar sobre la contemplación de “el yo” por el sujeto mismo cuando exporta a las redes sociales su imagen personal; para ello crea un relato entre palabras e imágenes con intención de ser aceptado. Se interpela mediante una reflexión crítica y se pone el enfoque de un prosumidor hipotético (Toffler, 1980) que aporta su versión de “el yo” con la que se identifica o hace por encajar entre realidad y deseo. Es un planteamiento interdisciplinar y multitextual de ese comunicar su rostro, su cuerpo y su vida por medio de unos parámetros positivos (Erikson, 1974; Festinger, 1957, Kaplún, 1998). Se observa la recurrencia para mostrarse uno mismo, sea con una imagen real y genuina o sea manipulada hacia la trazada y alzada de una versión idealizada (Barker, 2020; Koffermann, 2024). Se propone una revisión para el diseño de algunos talleres cuyos objetivos versan sobre el fomento de la autoestima, el afianzamiento de estrategias para la aceptación y la apertura a la diversidad. Además, se elige un formato ensayístico para tamizar y percibir ese impacto de la versión o las versiones de la autoimagen de adolescentes en las redes sociales, lo que será presentado como un reto de la formación del profesorado en educación mediática (https://www.redalfamed.org/vii-congreso-2024-costarica). A partir de la discusión constructiva, se pretende ofrecer pautas para la intervención, tanto desde el ámbito de la educación como desde el área de salud; las estrategias se sustentan en el análisis del relato multimodal que emerge de las definiciones con las que cada sujeto proyecta su “yo”.
Eighteen-Month Hybrid Closed-Loop Use in Very Young Children With Type 1 Diabetes: A Single-Arm Multicenter Trial
Authors: Ware Julia , Allen Janet M. , Boughton Charlotte K. , Wilinska Malgorzata E. , Hartnell Sara , Thankamony Ajay , de Beaufort Carine , Campbell Fiona M. , Fröhlich-Reiterer Elke , Fritsch Maria , Hofer Sabine E. , Kapellen Thomas M. , Rami-Merhar Birgit , Tauschmann Martin , Hovorka Roman ,   KidsAP Consortium, Hovorka Roman , Acerini Carlo L , Thankamony Ajay , Boughton Charlotte K , Dovc Klemen , Ware Julia , Musolino Gianluca , Wilinska Malgorzata E , Allen Janet M , Hartnell Sara , Ruan Yue , Ashcroft Nicole , Haydock Matthew , Hill Catherine , Fritsch Maria , Jasser-Nitsche Hildegard , Mader Julia K , Faninger Kerstin , Kapellen Thomas M , Bartelt Heike , Thiele Alena , Rami-Merhar Birgit , Berger Gabriele , Blauensteiner Nicole , Gellai Renata , Nagl Katrin , Tauschmann Martin , Cvach Sarah , Katzenbeisser-Pawlik Sonja , Hofer Sabine E , Abt Daniela , Malik Anita , Lanthaler Barbara , Wenzel Matthias , Campbell Fiona , Yong James , Metcalfe Emily , Allen Majorie , Ambler Sarah , Waheed Saima , Exall Jane , Tulip Joseph , de Beaufort Carine , Schierloh Ulrike , Fichelle Muriel , Schaeffer Dominique , Lawton Julia , Rankin David , Hart Ruth , Kimbell Barbara , Roze Stéphane , Jones Timothy , Patterson Chris , Adolfsson Peter 
Published: October 2024

OBJECTIVE
We aimed to evaluate the longer-term safety and efficacy of hybrid closed-loop (CL) therapy in very young children with type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
Following a 16-week multinational, randomized crossover trial comparing hybrid CL with sensor-augmented pump (SAP) therapy in 74 very young children aged 1–7 years with T1D, participants were invited to an extension phase using CL for a further 18 months. Outcomes were compared with the primary-phase SAP period and primary-phase CL period.

RESULTS
After the primary study phase, 60 participants were eligible to enroll in the extension. Of these, 49 consented (mean ± SD age 6.6 ± 1.5 years) to continue use of CL for 18 months. Percentage time in range (TIR) 3.9–10.0 mmol/L was 8.4 percentage points (95% CI 6.7–10.1; P &lt; 0.001) higher, while HbA1c was 0.4% ([5.0 mmol/mol], 95% CI 0.3–0.6 [3.7–6.2]; P &lt; 0.001) lower during the CL extension phase compared with primary-phase SAP period. At 18 months, mean HbA1c was 6.7 ± 0.5% and TIR was 70 ± 7%, compared with 6.7 ± 0.5% and 71 ± 6% in the primary-phase CL period. Time in hypoglycemia (&lt;3.9 mmol/L) was similar between CL extension phase and both primary-phase SAP (P = 0.31) and CL periods (P = 0.70). There were two severe hypoglycemia events and one other serious adverse event during the extension phase. One unexpected serious adverse device effect occurred.

CONCLUSIONS
Use of the Cambridge hybrid CL system led to sustained improvements in glycemic control lasting more than 18 months in very young children with T1D.
Estimating quantiles in acceptance criteria for structural components
Authors: Pajari Matti , Makkonen Lasse 
Published: October 2024

The probabilistic foundations of methods to control the characteristic properties of structural materials, expressed as p-quantiles, are discussed. We argue that the acceptance criteria in the quality control should be based on quantile estimators complying with the definition of the quantile. We introduce the distribution-free concept of definition-based quantile estimator. For normal distribution, an application of different types of estimators, as well as some attribute methods and mixed methods presently used, are illustrated by operating characteristic curves. We recommend the prediction method by which the subjective limit values of the mixed methods are eliminated, information from the sample will be used more effectively than in the attribute methods, and the questions about the proper confidence level or a “known” variation coefficient need not be considered. However, the direct application of the prediction method results in stricter quality control than that presently used. Therefore, we recommend adopting p’ > p in such a way that if the predicted p’-quantile estimate is equal to or higher than the lower lilmit L, the required value of the p-quantile, the lot is accepted in the quality control. If the present quality level is appropriate, the value of p’ can be chosen in such a way that the present level is maintained. If not, necessary modifications are possible simply by adjusting p’.
A comparative analysis of antioxidant, anti-inflammatory, and anticancer activities of the crude and fractionated extracts from Distichochlamys benenica
Authors: Tran Gia-Buu , Do Bich Hang , Tran Xuan Thao Thi , Pham Ty Viet , Do Duy Thanh 
Published: October 2024

Abstract

Distichochlamys benenica is a newly discovered plant belonging to the Distichochlamys family, which exerts many important biological activities. However, the anti-cancer, anti-inflammatory, and anti-oxidant effects of the crude (ME) and fractioned extracts of D. benenica, such as hexane (HE), chloroform (CE), and ethyl acetate extracts (EAE), have not been elucidated yet. The antioxidant activity of the extracts was evaluated via DPPH free radical scavenging and phosphomolybdate assays. The anti-inflammatory potential of the extracts was assessed via their inhibitory effects on protein denaturation and nitric oxide production. The anti-cancer effect of the extracts against A549 and MDA-MB-231 cell lines was determined via MTT assay. The results revealed that among four extracts, the polyphenol concentration was highest in EAE (350.59 ± 13.26 mg GAE/g) while the flavonoid content was highest in HE and ME. Furthermore, the greatest DPPH radical capture efficiency was demonstrated by EAE (89.76 ± 0.68%), and total antioxidant activity was greatest in HE (204.18 ± 3.51 mg AAE/g). The greatest suppression of NO generation was similarly shown by EAE and HE, with IC50 values ranging from 3.72-4.06 µg/mL, respectively. Additionally, HE and EAE exhibited an inhibitory effect on protein denaturation (ranging from 12.76%-28.81%). HE and EAE had the greatest effectiveness against MDA-MB-231 cell lines in the antitumor test. These findings validate the potent antioxidant, anti-inflammatory, and anti-cancer properties of D. benenica extracts, especially EAE and HE, and pave the way for the application of the extracts in the pharmaceutical industry as promising anti-inflammatory and anti-cancer medicines.
Extraction and Analysis of Mycotoxins from Whole Wheat Flour - A Methods Efficiency Comparison
Authors: Ciko Krisida , Kola Suzana , Bacu Ariola 
Published: October 2024

Abstract
Wheat is considered as staple food source for 40% of the population worldwide. Yet, the yield and quality can be compromised by fungal diseases, which are also responsible for mycotoxins presence at wheat seeds and originating foodstuff. In this context, the tackling of this problem by developing regulatory limits and standards have induced the development of various methods for sampling, extraction, identification and quantification of mycotoxins in food samples. This review addresses the comparison of the technical and cost efficiency of methods for the extraction and qualitative- quantitative analysis of mycotoxins from whole wheat flour. Methods of extraction such as the Solvent Extraction method, the Liquid Liquid Extraction, the Solid Liquid Extraction, the Solid Phase Extraction, the Immuno-Affinity Columns, the QuEChERS, and the use of absorbent nanomaterials such as graphene oxide and multi-walled carbon nanotubes in extraction procedures, are described in principle, technical details are presented, and examples of reported use are given. Methods of mycotoxin analysis such as Immunological Assays (LFIA, ELISA, FPIA), the Sensor-based (Surface Plasmon Resonance Sensor, Piezoelectric Sensors, Electrochemical Sensors, Colorimetric Sensors), and Chromatographic Techniques (TLC, GC, HPLC, HPLC-FLD, LC-MS/MS, UPLC-MS/MS, UHPLC-MS/MS, UFLC-MS/MS) are reviewed. To compare their efficiency, main advantages and disadvantages, the ongoing improvements, as well as the validation parameters (linearity, recovery range, RSDr range, RSDR %, LOQ range, and cut off) are summarized, and pairing of extraction to analysis methods for specific mycotoxins is provided. It was evidenced that none of methods already in use is capable of analyzing all mycotoxin categories at once, because of their chemical characteristics (volatile/non-volatile, co-elution, UV absorption, fluorescence) versus methods restrictions (matrix interferences, cross-reactivity of antibodies, selectivity and reproducibility of data, need for derivatization, etc). Also, depending on the purpose of the analysis (research or screening as part of legal requirements), to date the immunological methods are only suitable for validated matrices, biosensors can be used for routine screening, and that GC-MS and HPLC-based methods fulfill the legal requirements. In conclusion, while the selectivity and accuracy of methods for mycotoxin detection is being improved rapidly (those sensor-based thanks to the use of nanoparticles, nanomaterials, aptasensors, etc., and the chromatographic techniques coupled with mass spectrometry offer a higher selectivity and sensitivity, low detection limits, maintained resolution performance), and the duration of the analysis, the cost, and the need for highly-skilled staff go in favor of rapid methods (immunological and sensors-based), it is the capacity to fulfill legal requirements, which will determine the trend and their future success in the market.
Process Management Framework for Health and Safety at Work (SST) Companies
Authors: Oliveira Leandro José de , Fenerich Francielle Cristina , Barbosa Danilo Hisano 
Published: October 2024

Objective: This study aims to develop and implement a process management framework for Occupational Safety and Health (OSH) companies, seeking to optimize the organization and execution of services, identifying improvement opportunities throughout the customer journey, from contract closure to renewal. The proposal is to offer an adaptable model that meets industry demands and enhances the operational efficiency of companies.

Theoretical Framework: The theoretical framework addresses the evolution of Regulatory Standards (NRs) since the 1970s and the importance of complying with labor laws for the safety and health of workers in Brazil. The role of eSocial, created in 2014 to unify and ensure the collection of employer information, is highlighted, as well as its function in alerting them to legal risks.

Method: The methodology used was action research, as defined by Oquist (1978). The research involved mapping the operational processes of OSH companies to identify areas for improvement. The first version of the framework was developed, tested, and based on the results, improved into a second version. The improvements were based on tests and validations conducted throughout the process.

Results and Discussion: The first version of the framework showed positive results but also highlighted the need for improvements, which were incorporated into the second version. Changes included the restructuring of steps and the addition of a new phase focused on the commercial process. Satisfaction surveys with internal and external clients, as well as accounting firms, indicated positive acceptance but also a lack of systemic vision among professionals, affecting the quality of the work.

Research Implications: The research implications are significant for the OSH sector. The developed framework improves the organization and efficiency of service-providing companies. The study also highlights the importance of performance indicators to monitor performance and mitigate risks, such as customer loss. It is recommended that future research explore the adaptation of the framework to new technologies and automation.

Originality/Value: The originality of this study lies in the creation of a process management framework specifically for OSH companies, where organization and efficiency are essential for complying with labor regulations and ensuring worker safety. The value of the work resides in its practical contribution to the sector, offering an adaptable model that can be improved based on feedback and technological advancements.