bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wheat preharvest herbicide application, whole‐grain flour properties, yeast activity and the degradation of glyphosate in bread
Authors: Gélinas Pierre , Gagnon Fleur , McKinnon Carole 
Published: January 2018

SummaryThe aim of this study was to determine the effects of wheat preharvest application of a glyphosate‐based herbicide (Roundup WeatherMax® with Transorb® 2 Technology) on whole‐grain flour composition and properties, including yeast activity. The effect of dough fermentation on the degradation of herbicide residues was also estimated. Grain samples from two hard red spring wheat varieties exceeded the maximum residue limits (5 mg kg−1) in Canada. Glyphosate had minor effects on wheat kernels composition and properties, including fructans content and yeast gassing power. No degradation of Roundup® or pure glyphosate was seen after dough fermentation for up to 4 h and baking. These results call for more scientific studies on glyphosate residues in wheat.
A massive incorporation of microbial genes into the genome ofTetranychus urticae, a polyphagous arthropod herbivore
Authors: Wybouw N. , Van Leeuwen T. , Dermauw W. 
Published: January 2018

AbstractA number of horizontal gene transfers (HGTs) have been identified in the spider miteTetranychus urticae, a chelicerate herbivore. However, the genome of this mite species has at present not been thoroughly mined for the presence of HGT genes. Here, we performed a systematic screen for HGT genes in theT. urticaegenome using theh‐index metric. Our results not only validated previously identified HGT genes but also uncovered 25 novel HGT genes. In addition to HGT genes with a predicted biochemical function in carbohydrate, lipid and folate metabolism, we also identified the horizontal transfer of a ketopantoate hydroxymethyltransferase and a pantoate β‐alanine ligase gene. In plants and bacteria, both genes are essential for vitamin B5 biosynthesis and their presence in the mite genome strongly suggests that spider mites, similar toBemisia tabaciand nematodes, can synthesize their own vitamin B5. We further show that HGT genes were physically embedded within the mite genome and were expressed in different life stages. By screening chelicerate genomes and transcriptomes, we were able to estimate the evolutionary histories of these HGTs during chelicerate evolution. Our study suggests that HGT has made a significant and underestimated impact on the metabolic repertoire of plant‐feeding spider mites.
Daily very low UV dose exposure enhances adaptive immunity, compared with a single high‐dose exposure. Consequences for the control of a skin infection
Authors: Cela Eliana M. , Gonzalez Cintia Daniela , Friedrich Adrian , Ledo Camila , Paz Mariela Laura , Leoni Juliana , Gómez Marisa Inés , González Maglio Daniel H. 
Published: January 2018

SummaryUltraviolet radiation (UVr) promotes several well‐known molecular changes, which may ultimately impact on health. Some of these effects are detrimental, like inflammation, carcinogenesis and immunosuppression. On the other hand, UVr also promotes vitamin D synthesis and other beneficial effects. We recently demonstrated that exposure to very low doses of UVr on four consecutive days [repetitive low UVd (rlUVd)] does not promote an inflammatory state, nor the recruitment of neutrophils or lymphocytes, as the exposure to a single high UV dose (shUVd) does. Moreover, rlUVd reinforce the epithelium by increasing antimicrobial peptides transcription and epidermal thickness. The aim of this study was to evaluate the adaptive immune response after shUVd and rlUVd, determining T‐cell and B‐cell responses. Finally, we challenged animals exposed to both irradiation procedures with Staphylococcus aureus to study the overall effects of both innate and adaptive immunity during a cutaneous infection. We observed, as expected, a marked suppression of T‐cell and B‐cell responses after exposure to an shUVd but a novel and significant increase in both specific responses after exposure to rlUVd. However, the control of the cutaneous S. aureus infection was defective in this last group, suggesting that responses against pathogens cannot be ruled out from isolated stimuli.
Carbon nanotube/graphene oxide‐added CaO‐B2O3‐SiO2 glass/Al2O3 composite as substrate for chip‐type supercapacitor
Authors: Lee Tae‐Ho , Cho Sung‐Hoon , Lee Tae‐Gon , Kim Hyo Tae , You In‐Kyu , Nahm Sahn 
Published: January 2018

AbstractA CaO‐B2O3‐SiO2 (CBS) glass/40 wt% Al2O3 composite sintered at 900°C exhibited a dense microstructure with a low porosity of 0.21%. This composite contained Al2O3 and anorthite phases, but pure glass sintered at 900°C has small quantities of wollastonite and diopside phases. This composite was measured to have a high bending strength of 323 MPa and thermal conductivity of 3.75 W/(mK). The thermal conductivity increased when the composite was annealed at 850°C after sintering at 900°C, because of the increase in the amount of the anorthite phase. 0.25 wt% graphene oxide and 0.75 wt% multi‐wall carbon nanotubes were added to the CBS/40 wt% Al2O3 composite to further enhance the thermal conductivity and bending strength. The specimen sintered at 900°C and subsequently annealed at 850°C exhibited a large bending strength of 420 MPa and thermal conductivity of 5.51 W/(mK), indicating that it would be a highly effective substrate for a chip‐type supercapacitor.
Assessment of left ventricular dyssynchrony by three‐dimensional echocardiography: Prognostic value in patients undergoing cardiac resynchronization therapy
Authors: Höke Ulas , Bax Jeroen J. , Delgado Victoria , Ajmone Marsan Nina 
Published: January 2018

AbstractBackgroundSystolic dyssynchrony index (SDI) using three‐dimensional echocardiography (3DE) was shown to be a reliable measure of left ventricular (LV) dyssynchrony. However, the prognostic value of SDI on long‐term outcomes after cardiac resynchronization therapy (CRT) remains unknown.Methods and resultsA total of 414 patients (mean age 67 ± 10 years, 60% ischemic etiology) with 3DE evaluation before CRT implantation were included. SDI was evaluated as continuous value and in quartiles. The study endpoint was combined all‐cause mortality, heart transplantation, and LV assist device implantation.At baseline, median SDI was 8.0% (IQR 5.6–11.3%). During a median follow‐up of 45 months (IQR 25–59 months), the endpoint was observed in 94 (23%) patients. SDI was independently associated with the endpoint together with ischemic etiology, diabetes, and renal function (HR 0.914, P = 0.003) after adjustment for age, atrial fibrillation, hemoglobin level, NYHA functional class, and posterolateral LV lead position. Patients from the 1st, 2nd, and 3rd SDI quartiles showed similar survival and superior as compared to the 4th quartile with the lowest SDI values (≤5.5%; χ²: 30.4, log‐rank P < 0.001). From receiver operating characteristic curve analysis, the optimal SDI cut‐off value associated with the endpoint was >6.8% (area under the curve 0.634). Finally, a subgroup analysis (293 patients) demonstrated that a more pronounced reduction in SDI immediately after CRT (resynchronization) was independently associated with superior survival (HR 0.461, P = 0.011) after adjustment for prognostic relevant parameters.ConclusionSDI is independently associated with long‐term prognosis after CRT and might therefore be important to optimize risk‐stratification in these patients.
Matrine reduces susceptibility to postinfarct atrial fibrillation in rats due to antifibrotic properties
Authors: Ma Jin , Ma Shiyu , Yin Chunxia , Wu Huanlin 
Published: January 2018

AbstractThis study aimed to investigate whether matrine could prevent atrial fibrillation (AF) after myocardial infarction by reducing left atrial fibrosis, and to determine the underlying mechanisms in isolated cardiac fibroblasts (CFs). Five weeks after MI, matrine‐treated rats had lower rates of AF inducibility and shorter AF duration than MI rats. Matrine improved the left atrial conduction velocity and homogeneity. Matrine decreased the fibrosis positive areas and the protein levels of type I collagen and type III collagen in the left atrium. Matrine inhibited CFs differentiation to myofibroblasts and the expression of transforming growth factor‐beta 1 and matrix metalloproteinase 9. In vitro, matrine inhibited the CFs proliferation, migration, differentiation, and secretion ability. These in vitro and in vivo data demonstrated that matrine has the potential to reduce susceptibility to AF after MI due, at least in part, to reduced atrial fibrosis via inhibiting CFs proliferation, migration, differentiation, and secretion ability.
Multiple roles of Ring 1 and YY1 binding protein in physiology and disease
Authors: Zhan Shaohua , Wang Tianxiao , Ge Wei , Li Jinming 
Published: January 2018

AbstractRing 1 and YY1 binding protein (RYBP) was first identified in 1999, and its structure includes a conserved Npl4 Zinc finger motif at the N‐terminus, a central region that is characteristically enriched with arginine and lysine residues and a C‐terminal region enriched with serine and threonine amino acids. Over nearly 20 years, multiple studies have found that RYBP functions as an organ developmental adaptor. There is also evidence that RYBP regulates the expression of different genes involved in various aspects of biological processes, via a mechanism that is dependent on interactions with components of PcG complexes and/or through binding to different transcriptional factors. In addition, RYBP interacts directly or indirectly with apoptosis‐associated proteins to mediate anti‐apoptotic or pro‐apoptotic activity in both the cytoplasm and nucleus of various cell types. Furthermore, RYBP has also been shown to act as tumour suppressor gene in different solid tumours, but as an oncogene in lymphoma and melanoma. In this review, we summarize our current understanding of the functions of this multifaceted RYBP in physiological and pathological conditions, including embryonic development, apoptosis and cancer, as well as its role as a component of polycomb repressive complex 1.
Secular changes in the symptom level of clinically diagnosed autism
Authors: Arvidsson Olof , Gillberg Christopher , Lichtenstein Paul , Lundström Sebastian 
Published: January 2018

BackgroundThe prevalence of autism has been reported to have increased worldwide. A decrease over time in the number of autism symptoms required for a clinical autism diagnosis would partly help explain this increase. This study aimed to determine whether the symptom level of clinically diagnosed autism cases below age 13 had changed over time.MethodsParents of Swedish 9‐year old twins (n = 28,118) participated in a telephone survey, in which symptoms and dysfunction/suffering related to neurodevelopmental disorders [including autism, but also attention‐deficit/hyperactivity disorder (ADHD), Developmental Coordination Disorder (DCD), and Learning Disabilities (LD)] in their children were assessed over a 10‐year period. Survey data was merged with the National Patient Register containing clinically registered autism diagnoses (n = 271).ResultsIn individuals who had been clinically diagnosed with autism before the age of 13, the symptom score for autism decreased on average 30% over more than a decade in birth cohorts 1992–2002. There was an average decrease of 50% in the autism symptom score from 2004 to 2014 in individuals who were diagnosed with autism at ages 7–12, but there was no decrease in those diagnosed at ages 0–6.ConclusionsOver time, considerably fewer autism symptoms seemed to be required for a clinical diagnosis of autism, at least for those diagnosed after the preschool years. The findings add support for the notion that the observed increase in autism diagnoses is, at least partly, the by‐product of changes in clinical practice, and flag up the need for working in agreement with best practice guidelines.
Reviewer selection biases editorial decisions on manuscripts
Authors: Hausmann Laura , Schweitzer Barbara , Middleton Frank A. , Schulz Jörg B. 
Published: January 2018

AbstractMany journals, including the Journal of Neurochemistry, enable authors to list peer reviewers as ‘preferred’ or ‘opposed’ suggestions to the editor. At the Journal of Neurochemistry, the handling editor (HE) may follow recommendations or select non‐author‐suggested reviewers (non‐ASRs). We investigated whether selection of author‐suggested reviewers (ASRs) influenced decisions on a paper, and whether differences might be related to a reviewer’s, editor's or manuscript's geographical location. In this retrospective analysis, we compared original research articles submitted to the Journal of Neurochemistry from 2013 through 2016 that were either reviewed exclusively by non‐ASRs, by at least one ASR, by at least one reviewer marked by the author as ‘opposed’ or none. Manuscript outcome, reviewer rating of manuscript quality, rating of the reviewers’ performance by the editor (R‐score), time to review, and the country of the editor, reviewers and manuscript author were analyzed using non‐parametric rank‐based comparisons, chi‐square (χ2) analysis, multivariate linear regression, one‐way analysis of variance, and inter‐rater reliability determination. Original research articles that had been reviewed by at least one ASR stood a higher chance of being accepted (525/1006 = 52%) than papers that had been reviewed by non‐ASRs only (579/1800 = 32%). An article was 2.4 times more likely to be accepted than rejected by an ASR compared to a non‐ASR (Pearson's χ2(1) = 181.3, p < 0.05). At decision, the editor did not simply follow the reviewers’ recommendation but had a balancing role: Rates of recommendation from reviewers for rejection were 11.2% (139/1241) with ASRs versus 29.0% (1379/4755) with non‐ASRs (this is a ratio of 0.39 where 1 means no difference between rejection rates for both groups), whereas the proportion of final decisions to reject was 24.7% (248/1006) versus 45.7% (822/1800) (a ratio of 0.54, considerably closer to 1). Recommendations by non‐ASRs were more favorable for manuscripts from USA/Canada and Europe than for Asia/Pacific or Other countries. ASRs judged North American manuscripts most favorably, and judged papers generally more positively (mean: 2.54 on a 1–5 scale) than did non‐ASRs (mean: 3.16) reviewers, whereas time for review (13.28 vs. 13.20 days) did not differ significantly between these groups. We also found that editors preferably assigned reviewers from their own geographical region, but there was no tendency for reviewers to judge papers from their own region more favorably. Our findings strongly confirm a bias toward lower rejection rates when ASRs assess a paper, which led to the decision to abandon the option to recommend reviewers at the Journal of Neurochemistry.Open Data: Materials are available on https://osf.io/jshg7/
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Papilla‐Crown Height Dimensions around Zirconium Dioxide Implants in the Esthetic Area: A 3‐Year Follow‐Up Study
Authors: Kniha Kim , Schlegel Karl Andreas , Kniha Heinz , Modabber Ali , Neukam Friedrich , Kniha Kristian 
Published: January 2018

AbstractPurposeSoft tissue interactions with ceramic dental implants have previously been shown to have favorable esthetic outcomes. This study aimed to evaluate the papilla‐crown proportion around zirconia implants in a 3‐year follow‐up study and the correlation between the gingival biotype and changes in papillary height.Materials and MethodsThis was a prospective study of 39 patients with 40 single‐gap implants (Straumann PURE Ceramic ZLA Implant). The papilla‐crown proportion was assessed after 3 months, 1 year, and 3 years. In addition, correlations between the peri‐implant biotypes and changes in papillary heights were evaluated.ResultsThe papilla‐crown proportion improved from 35.5% after 3 months to 41.7% after 3 years. The gingival biotype was correlated very weakly to papilla height alterations. Significant papillary fill was observed in the interdental space between 3 months and 3 years (p < 0.001).ConclusionsAn ideal papilla‐crown proportion of 40% around single implants was observed after 3 years. A thin or thick gingival biotype showed a very weak correlation with soft tissue alterations.
Are the benefits of autonomy satisfaction and the costs of autonomy frustration dependent on individuals' autonomy strength?
Authors: Van Assche Jasper , van der Kaap‐Deeder Jolene , Audenaert Elien , De Schryver Maarten , Vansteenkiste Maarten 
Published: January 2018

AbstractObjectiveFrom a self‐determination theory perspective, individuals are assumed to benefit and suffer from, respectively, the satisfaction and frustration of the psychological need for autonomy, even if they score low on autonomy strength. Yet, previous studies on need strength are scarce, operationalized need strength differently, and produced inconsistent findings.MethodIn two studies among 224 South African adults (Mage = 24.13, SD = 4.25; 54.0% male) and 156 Belgian prisoners (Mage = 38.60, SD = 11.68; 88.5% male), we investigated the moderating role of autonomy valuation and desire in the relations of autonomy satisfaction and frustration with a variety of well‐being and ill‐being indicators.ResultsStudy 1 provided some evidence for the moderating role of mostly explicit autonomy desire (rather than explicit autonomy valuation). In Study 2, neither explicit nor implicit autonomy desire played a consistent moderating role.ConclusionsOverall, these findings are congruent with a moderate (albeit not with a strong) interpretation of the universality claim made within self‐determination theory, provide initial evidence for a differentiation between deficit‐based and growth‐oriented interpersonal differences in need strength, and indicate that the potential moderating role of need strength deserves continued attention before any firm conclusions can be drawn.
Socioeconomic and behavioral determinants of tooth brushing frequency: results from the representative French 2010 HBSC cross‐sectional study
Authors: Fernandez de Grado Gabriel , Ehlinger Virginie , Godeau Emmanuelle , Sentenac Mariane , Arnaud Catherine , Nabet Cathy , Monsarrat Paul 
Published: January 2018

AbstractObjectivesTo describe tooth brushing frequency and its association with a wide range of socioeconomic and behavioral characteristics, using a nationally representative sample of school‐aged children in France.MethodsOur sample included 11,337 students aged from 10 to 16 years, who answered the HBSC questionnaire. Some variables were grouped into composite variables, thus generating scores for: eating habits, health and body, relationships with parents, socioeconomic status (SES) of family, and school life. Multivariate logistic regression analyses were used to study the relationship between these variables and tooth brushing frequency.ResultsGirls were more likely to brush twice a day than boys [adjusted Odds Ratio: aOR 2.47, 95 percent confidence interval CI95% (1.97; 3.11), aOR 1.89, CI95% (1.56; 2.29), aOR 1.45, CI95% (1.25; 1.68) for low, mid, and high school life score, respectively]. Students were more likely to brush twice a day when they had high (versus low) scores for healthy eating habits [aOR = 1.60; 95 percent CI: (1.40; 1.83)], well‐being concerning health and body [aOR = 1.61; 95 percent CI: (1.40; 1.86)] and SES [aOR = 1.25; 95 percent CI: (1.09; 1.43)].ConclusionsWe believe that preventive health campaigns should target school and family environments more specifically to reach the most disadvantaged sections of the population and include promotion of whole health. The messages should be designed to efficiently reach adolescents, e.g., by appealing to their maturity, self‐esteem, and emotional factors. Through the incorporation of qualitative research elements, identifying the reasons for not brushing twice a day would also help to develop new prevention programs.
Reversal of visceral hypersensitivity in rat by Menthacarin®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation
Authors: Botschuijver S. , Welting O. , Levin E. , Maria‐Ferreira D. , Koch E. , Montijn R. C. , Seppen J. , Hakvoort T. B. M. , Schuren F. H. J. , de Jonge W. J. , van den Wijngaard R. M. 
Published: January 2018

AbstractBackgroundIrritable bowel syndrome (IBS) is a common gastrointestinal disorder associated with altered gastrointestinal microflora and increased nociception to colonic distension. This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. Menthacarin® is a proprietary combination of essential oils from Mentha x piperita L. and Carum carvi. Because these oils exhibit antifungal and antibacterial properties, we investigated whether Menthacarin® can reverse existing visceral hypersensitivity in maternally separated rats.MethodsIn non‐handled and maternally separated rats, we used the visceromotor responses to colorectal distension as measure for visceral sensitivity. We evaluated this response before and 24 hours after water‐avoidance stress and after 7 days treatment with Menthacarin® or control. The pre‐ and post‐treatment mycobiome and microbiome were characterized by sequencing of fungal internal transcribed spacer 1 (ITS‐1) and bacterial 16s rDNA regions. In vitro antifungal and antimicrobial properties of Menthacarin® were studied with radial diffusion assay.Key ResultsMenthacarin® inhibited in vitro growth of yeast and bacteria. Water‐avoidance caused visceral hypersensitivity in maternally separated rats, and this was reversed by treatment. Multivariate analyses of ITS‐1 and 16S high throughput data showed that maternal separation, induced changes in the myco‐ and microbiome. Menthacarin® treatment of non‐handled and maternally separated rats shifted the mycobiomes to more similar compositions.Conclusions & InferencesThe development of visceral hypersensitivity in maternally separated rats and the Menthacarin®‐mediated reversal of hypersensitivity is associated with changes in the mycobiome. Therefore, Menthacarin® may be a safe and effective treatment option that should be tested for IBS.
IgG4‐mediated autoimmune diseases: a niche of antibody‐mediated disorders
Authors: Huijbers Maartje G. , Plomp Jaap J. , van der Maarel Silvère M. , Verschuuren Jan J. 
Published: January 2018

AbstractImmunoglobulin 4 (IgG4) is one of four human IgG subclasses and has several unique functional characteristics. It exhibits low affinity for complement and for most Fc receptors. It furthermore has generally high affinity for its antigen, with binding occurring in a monovalent fashion, as IgG4 can exchange Fab‐arms with other IgG4 molecules. Because of these characteristics, IgG4 is believed to block its targets and prevent inflammation, which, depending on the setting, can have a protective or pathogenic effect. One example of IgG4 pathogenicity is muscle‐specific kinase (MuSK) myasthenia gravis (MG), in which patients develop IgG4 MuSK autoantibodies, resulting in muscle weakness. As a consequence of the distinct IgG4 characteristics, the pathomechanism of MuSK MG is very different from IgG1‐and IgG3‐mediated autoimmune diseases, such as acetylcholine receptor MG. In recent years, new autoantibodies in a spectrum of autoimmune diseases have been discovered. Interestingly, some were found to be predominantly IgG4. These IgG4‐mediated autoimmune diseases share many pathomechanistic aspects with MuSK MG, suggesting that IgG4‐mediated autoimmunity forms a separate niche among the antibody‐mediated disorders. In this review, we summarize the group of IgG4‐mediated autoimmune diseases, discuss the role of IgG4 in MuSK MG, and highlight interesting future research questions for IgG4‐mediated autoimmunity.