bluuebunny/crossref_metadata_2025_split huggingface dataset:
RACK1 and NEK7 mediate GSDMD-dependent macrophage pyroptosis upon Streptococcus suis infection
Authors: Shen Xin , Ran Jinrong , Yang Qingqing , Li Bingjie , Lu Yi , Zheng Jiajia , Xu Liuyi , Jia Kaixiang , Li Zhiwei , Peng Lianci , Fang Rendong 
Published: September 2024

AbstractStreptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that induces an NLRP3-dependent cytokine storm. NLRP3 inflammasome activation triggers not only an inflammatory response but also pyroptosis. However, the exact mechanism underlying S. suis-induced macrophage pyroptosis is not clear. Our results showed that SS2 induced the expression of pyroptosis-associated factors, including lactate dehydrogenase (LDH) release, propidium iodide (PI) uptake and GSDMD-N expression, as well as NLRP3 inflammasome activation and IL-1β secretion. However, GSDMD deficiency and NLRP3 inhibition using MCC950 attenuated the SS2-induced expression of pyroptosis-associated factors, suggesting that SS2 induces NLRP3-GSDMD-dependent pyroptosis. Furthermore, RACK1 knockdown also reduced the expression of pyroptosis-associated factors. In addition, RACK1 knockdown downregulated the expression of NLRP3 and Pro-IL-1β as well as the phosphorylation of P65. Surprisingly, the interaction between RACK1 and P65 was detected by co-immunoprecipitation, indicating that RACK1 induces macrophage pyroptosis by mediating the phosphorylation of P65 to promote the transcription of NLRP3 and pro-IL-1β. Similarly, NEK7 knockdown decreased the expression of pyroptosis-associated factors and ASC oligomerization. Moreover, the results of co-immunoprecipitation revealed the interaction of NEK7-RACK1-NLRP3 during SS2 infection, demonstrating that NEK7 mediates SS2-induced pyroptosis via the regulation of NLRP3 inflammasome assembly and activation. These results demonstrate the important role of RACK1 and NEK7 in SS2-induced pyroptosis. Our study provides new insight into SS2-induced cell death.
Validation of Rosenberg self-esteem scale among Norwegian adolescents – psychometric properties across samples
Authors: Moksnes U.K , Espnes G.A , Eilertsen M.E.B , Bjørnsen H.N , Ringdal R , Haugan Gørill 
Published: September 2024

Abstract
Background
Self-esteem refers to the evaluative and affective dimensions of the self-concept and is important for positive mental health and overall functioning during adolescence. The Rosenberg Self-esteem scale (RSES) is one of the most frequently used and widely accepted instruments assessing self-esteem; however, the psychometric properties of the instrument have not been investigated in a Norwegian adolescent population. The present study’s aim is to investigate the factor structure, construct validity and reliability of the RSES among adolescents 14–21 years.

Methods
The study was based on two cross-sectional samples (n = 1,233/ n = 1,816) of adolescents from rural and urban areas in Mid-Norway. Concerning the dimensionality of the RSES, two measurement models were tested using Principal Component Analysis and Confirmatory Factor Analysis: a one-factor model and a two-factor-model.

Results
The results show that a two-factor solution of positive and negative aspects of self-esteem representing “perceived personal competence” and “self-value” had the best fit across the two adolescent samples. The RSES also showed high reliability and correlated in expected directions with measures of life satisfaction, stress, and self-efficacy, supporting the convergent validity of the instrument.

Conclusion
The psychometric properties of the RSES need to be further evaluated in Norwegian adolescent populations based on the dimensionality found in the present study; however overall, the results indicate that the instrument is appropriate for assessing self-esteem among Norwegian adolescents.
Reinforcement structure design and matrix model establishment of tubular 3D weaving based on ordinary loom
Authors: Wang Xu , Li Shaocong , Xiang Duowen 
Published: September 2024

AbstractIn order to optimize the design of three-dimensional tubular woven (3DTW), a design method and matrix model of 3DTW were proposed based on normal loom, where 3D woven was used as tube wall and the weaving method of tubular fabric was applied. Herein, 3D woven was used as the tube wall to obtain the face weave diagram, and the back weave diagram was subsequently obtained by the “negative flip” method. According to the method of layering weaving, the structure diagram of 3DTW could be determined. In order to obtain back weave matrix, the elements in the face weave matrix were replaced and reordered by MATLAB function, and Kronecker product operation was used to achieve the proportional embedding of the face and the back weave matrix and the assignment of the face warp by lifting point elements when weaving the back weft. Finally, the weave matrix of 3DTW was obtained. The proposed design method and matrix model can improve the design efficiency and reduce weaving cost of 3DTW, which could provide a reference for the design and preparation of 3DTW.
Ethanol extract of Nymphaea lotus Linn. inhibited hepatic fibrogenesis in carbon tetrachloride-intoxicated Wistar rats
Authors: Oyeyemi Ifeoluwa Temitayo , Adesina Isaac Ayodeji , Sulaiman Kabirat Adedunmola , Ajayi Ifeoluwa Temitope , Nabofa Enivwenaye Egide Williams 
Published: September 2024

Abstract
Background
Nymphaea lotus is a plant used as food and to manage various ailments including liver diseases. Liver fibrosis is a pathological state which progresses to more chronic and fatal liver diseases but without any approved drug yet. This study thus aimed to investigate the anti-liver fibrosis mechanism of N. lotus.

Methodology
Liver fibrosis was induced by carbon tetrachloride (CCl4:Olive oil, 1:1 ip). Fibrotic animals were treated with 50, 100 and 200 mg/kg b.wt. N. lotus extract. The activities of alanine aminotransaminase (ALT), aspartate aminotransferase (AST), in the serum, and levels of Malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and reduced glutathione (GSH) in the liver, and histopathology of the liver were determined. The expression of fibrosis-related proteins namely alpha-smooth muscle actin (α-SMA), Collagen-4 (COL4A), Transforming growth factor-β1 (TGFβ1), Mothers against decapentaplegic homolog 2 (SMAD2), SMAD3 and matrix metalloproteinase 2 (MMP2) in the liver was also evaluated. Molecular docking and simulation analysis of N. lotus-derived phytochemicals to TGFβ1 and SMAD3 was also performed.

Results
The extract significantly reduced the levels of ALT, AST, and MDA, increased the expression of antioxidant enzymes namely; SOD and GSH, and downregulated the expression of fibrosis-related proteins namely α-SMA, COL4A, TGFβ1, SMAD3 and MMP2. It also ameliorated CCl4-induced hepatic lesions. N. lotus-derived phytochemicals also showed a good binding affinity and interaction with the active sites of TGFβ1 and SMAD3.

Conclusion
N. lotus inhibited liver fibrosis by inhibiting oxidative stress and the TGFβ/SMAD signalling pathway. This demonstrates its beneficial and protective effect against CCl4-induced hepatoxicity and thus supports its use for the traditional management of liver diseases.
Validity and reliability of the Chinese version of human–robot interaction self-efficacy scale in Chinese adults
Authors: Gao Huixin , Wang Wei , Huang Chengli , Xie Xinru , Wang Duming , Gao Wei , Cai Jie 
Published: September 2024

Abstract
Background
With the fast-paced advancements of robot technology, human–robot interaction (HRI) has become increasingly popular and complex, and self-efficacy in HRI has received extensive attention. Despite its popularity, this topic remains understudied in China.

Objective
In order to provide a psychometrically sound instrument in China, this study aimed to translate and validate the Self-Efficacy in Human–Robot Interaction Scale (SE-HRI) in two Chinese adult samples (N1 = 300, N2 = 500).

Methods
The data was analyzed by SPSS 26.0 and Amos 24.0. Item analysis and exploratory factor analysis were conducted using Sample 1 data. Confirmatory factor analysis, criterion-related validity analysis, and reliability analysis were then performed using Sample 2 data.

Results
The results revealed that the Chinese SE-HRI scale consisted of 13 items in a two-factor model, suggesting a good model fit. Moreover, general self-efficacy and willingness to accept the use of artificial intelligence (AI) were both positively correlated with self-efficacy in HRI, while negative attitudes toward robots showed an inverse correlation, proving the Chinese SE-HRI scale exhibited excellent criterion-related validity.

Conclusion
The Chinese SE-HRI scale is a reliable assessment tool for evaluating self-efficacy in HRI in China. The study discussed implications and limitations, and suggested future directions.
Psychometric properties of the Parenting Stress Index-Short Form in a Peruvian sample
Authors: González-López Katlin T. , Vásquez-Chingay Sheyra N. , Rodrigo-Tintaya Raquel A. , Leiva-Colos Flor V. , Morales-García Wilter C. , Adriano-Rengifo Cristian E. 
Published: September 2024

Abstract
Background
The stress experienced by parents in fulfilling their parental role has consequences for couple dynamics, parent–child interactions, and the mental health of parents. However, studies on the psychometric properties of the PSI-SF, particularly among Latin American parents, are scarce. Therefore, this study aims to evaluate the psychometric properties of the Spanish version of the Parenting Stress Index-Short Form (PSI-SF).

Methods
The participants were Peruvian mothers and fathers with children in early childhood and primary education, with a mean age of 34.4 years (SD = 6.8). The sample was obtained in two phases: 130 participants for the Exploratory Factor Analysis (EFA) and 791 participants for the Confirmatory Factor Analysis (CFA).

Results
The study results show a modified three-factor structure of the PSI-SF scale, with adequate fit indices (GFI = .99, AGFI = .99, SRMR = .024, CFI = .98, TLI = .98, RMSEA = .074) and loadings above 0.40. Additionally, the three factors of the scale demonstrated high reliability, with Cronbach's alpha and McDonald's omega values for Parental Distress (α = .94; ω = .95), Parent–Child Dysfunctional Interaction (α = .97; ω = .97), and Difficult Child (α = .94; ω = .94). The scale was also found to be invariant with respect to gender.

Conclusion
In conclusion, the study results suggest that the modified PSI-SF has adequate psychometric properties and is invariant for assessing parental stress in Peruvian fathers and mothers with children in early childhood and primary education.
Role of photosensitizer in control of mealybug and scale insects (Homoptera: Margarodidae and Diaspididae), in comparison with conventional insecticide
Authors: Salem Hamdy Abdel-Naby , Sabry Al-kazafy Hassan , El-den Aref Noeman Bahaa 
Published: September 2024

Abstract
Background
Two photosensitizer agents were used: rose bengal and eosin alone and mixed with soap. Two other chemical compounds were used: active cable oil and soap. All these materials were compared with malathion as a conventional insecticide. The Egyptian mealybug Icerya aegyptiaca attacking ornamental–medicinal plants (acalypha and rose shrubs) and the black Parlatoria scale Parlatoria ziziphus attacking sour orange were evaluated against the tested materials.

Results
The results obtained suggest that soap, rose bengal mixed, eosin mixed, malathion and active cable oil revealed potency in reducing the population of I. aegyptiaca by 57.24, 87.25, 75.62, 98.71 and 59.91%, respectively, on rose; and by 54.91, 82.64, 62.48, 96.67 and 48.13%, respectively, on acalypha shrubs; their potency on insects showed a significant difference on infested rose than on infested acalypha. The tested compounds revealed lower potency in reducing the population of P. ziziphus than malathion. Reduction percentages were 35.43, 40.39, 34.25, 91.81 and 28.21%, respectively. The accumulation potency of the tested compounds on two insects collectively, without regard to insect species, stages or infested plant species, was assessed at 51.49, 66.18, 55.86, 94.37 and 44.69, respectively. The obtained results confirmed that malathion was the most effective agent against both tested insects, followed by rose bengal mixed with soap, eosin mixed with soap, soap alone and active cable oil.

Conclusions
The obtained results showed that rose bengal (as a photosensitizers) mixed with soap can be used as a promising agent against all tested insects.
Shear wave elastography as a diagnostic tool in biliary atresia and liver fibrosis
Authors: Elzayat Wessam Abdelrahman , Hussien Aya Bahaa , Adel Noha , Emad-Eldin Sally 
Published: September 2024

Abstract
Background
The study aims to investigate Shear Wave Elastography's accuracy in assessing pediatric cholestasis and differentiating biliary atresia from other causes. The early diagnosis of cholestasis in newborns, when caused by true liver disease and not physiological or transient jaundice is usually eluded. To maximize the diagnostic reliability of ultrasound as an initial imaging modality to diagnose biliary atresia, ultrasound elastography has been introduced as a quantitative non-invasive sonographic technique to measure liver stiffness which is presumed to be different in biliary atresia from other cholestasis as well as follow-up liver stiffness post-Kasai operation.

Results
Ten patients (34.48%) were diagnosed with cholestasis with normal/low GGT. Five patients (17.24%) were diagnosed with hepatitis, and 2 patients had syndromes (10.34%). Other causes were found in 11 patients (37.93%). Major bile duct obstruction with fibrosis/cirrhosis was the majority of findings found in biliary atresia patients (100%), most of them with mild fibrosis (40%), followed by moderate (36.67%), then marked fibrosis (13.33%) and secondary cirrhosis (10%). ROC curve analysis shows that the best cut-off value for SWE = 1.97 with a sensitivity of 75.0% and specificity of 83.5%, with positive and negative predictive values were 82.8% and 74.1%, respectively. Mean shear wave elastography was significantly higher among the biliary atresia group (median 2.86) than in non-biliary atresia (median 1.81) and control groups (median 1.64) (P < 0.001) The best cut-off value of shear wear elastography for predicting outcome in pediatric patients post-Kasai procedure was 3.55, with a sensitivity of 66.7%, specificity of 64.7%, positive and negative predictive values were 25% and 91.7% respectively, with accuracy 65%.

Conclusion
The results of this study suggest that shear-wave elastography is a useful diagnostic tool for differentiating biliary atresia from other causes of cholestasis in pediatric patients, with a high sensitivity and specificity. Further studies are needed to validate the findings and determine the optimal cut-off value for shear wear elastography in clinical practice.
Neuropathic pain, antidepressant drugs, and inflammation: a narrative review
Authors: Catalisano Giulia , Campione Gioacchina Martina , Spurio Giulia , Galvano Alberto Nicolò , di Villalba Cesira Palmeri , Giarratano Antonino , Alongi Antonietta , Ippolito Mariachiara , Cortegiani Andrea 
Published: September 2024

Abstract

Background
Neuropathic pain (NP) is a chronic and disabling condition, caused by a lesion or disease of the somatosensory nervous system, characterized by a systemic inflammatory state. Signs and associated symptoms are rarely recognized, and response to usual analgesic drugs is poor. Antidepressant drugs are first-line agents for the treatment of NP. This narrative review aims to summarize the role of antidepressant drugs in treating NP and their mechanism of action, focusing on the effects on inflammatory cytokines.
Main text.
Peripheral nerve injury leads to a local inflammatory response and to the disruption of the blood-medullary barrier, allowing the influx of peripheral immune cells into the central nervous system. Antidepressants have antinociceptive effects because they recruit long-term neuronal plasticity. Amitriptyline modulates the inflammatory response due to the reduction of the mRNA of pro-inflammatory cytokines acting as an adenosine agonist and leading to the activation of the A3AR receptor. Through toll-like receptors, local inflammation determines the release of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) that drives and stimulates the hyperflammation in NP. Nortriptyline has an important antiallodynic effect in NP as it determines the recruitment of norepinephrine in the dorsal root ganglia. By modulating the β2-adrenoreceptors expressed by non-neuronal satellite cells, it inhibits the local production of TNF-α and determines a reduction of NP symptoms. Following the administration of antidepressants, there is a reduction in the production of TNF-α in the brain which in turn transforms the function of the α2-adrenergic receptor from an inhibitor to an activator of the release of norepinephrine. This is important to prevent the development of chronic pain.

Conclusion
Inflammatory cytokines are the main players in a bidirectional communication between the central and peripheral nervous system and the immune system in NP. Antidepressants have an important role in NP. Further research should explore the interaction between neuroinflammation in NP, the effects of antidepressants and the clinical relevance of this interaction.
Bending the “Iron Triangle”
Authors: Sheingate Adam 
Published: September 2024

Abstract
The “iron triangle” concept originated in a set of debates about power and influence in the US political system. Applied to agriculture, the iron triangle described a set of political relationships in which farmers and their representatives enjoyed a privileged position in the policy process. Although the contemporary reality is much messier than the triangle metaphor implies, agricultural policy in the United States continues to reflect the power and influence of large-scale commercial farmers and their allies in adjacent sectors such as insurance and banking. This continued dominance reflects an ongoing process of political and policy adaptation that enables the productivist core of the farm sector to retain much of its power despite broader changes in the political and economic context of US agriculture.
The Marginalization of the Environment in Agricultural Policy
Authors: Secchi Silvia 
Published: September 2024

Abstract
From its inception, US settler agriculture has used extractive and unsustainable practices. Farm bill agricultural conservation policy since the 1930s has been based on largely ineffective approaches unable to address the environmental problems caused by agriculture. Conservation policies have consistently had both income support and environmental purposes, and have been largely countercyclical: conservation funding decreases when crop and livestock prices are higher, as income support becomes less important. This happens even though higher prices typically cause environmental stressors to get worse, indicating that conservation is ancillary to productivist goals. This is also apparent from the repeated funding of production-enhancing practices under the guise of conservation. In parallel terms, environmental concerns were and remain peripheral to the “iron triangle” conceptualization. The still-marginal role that environmental issues play in agricultural policy is a huge problem, particularly as climate change impacts, adaptation, and mitigation become more crucial in the farm sector.
Ending Neoliberalism
Authors: Vallelly Neil 
Published: September 2024

Abstract
The COVID-19 pandemic ushered in a new round of obituaries for neoliberalism, with some declaring that we have entered the stage of “postneoliberalism.” Rather than weighing in on the debates about whether neoliberalism has or has not ended, this article reflects on the theoretical framework in which neoliberalism's end has come to be posited. The article calls this framework “ending,” which allows the theorist to make “imaginative investments in coherent patterns” (Frank Kermode) with beginnings, middles, and ends. By drawing on Kermode's literary theory, the article lays out three key features of ending as a theoretical framework: a teleological vision of history; a Euro- and Anglocentric view of neoliberalism; and a distinction between a neoliberal policy paradigm and modes of subjectification. The article then goes on to explore the political limitations of ending, especially for the left, through a reading of Gary Gerstle's The Rise and Fall of the Neoliberal Order (2022). To finish, the article seeks to resurrect ending as a metatheoretical device in which ending as a framework becomes the subject of theorization. Doing so, the article proposes, helps the left to reflect on the position from which it analyzes neoliberalism, as well as to better connect such reflection to concrete political projects that seek to actively end neoliberalism.
Postexposure Pestes-des-petits-ruminants vaccination with oxytetracycline therapy mitigates severe disease and increases survivability in natural infections
Authors: Ezeasor C , Shoyinka S , Emikpe B , Ihedioha J 
Published: September 2024

The potentials of post-exposure intranasal (IN) and subcutaneous (SC) Peste des petits ruminants vaccination (PPRVc) with concurrent oxytetracycline (oxytet.) treatment in the management of PPR outbreaks in goats were investigated. Twenty-eight (28) West African dwarf goats, were randomly assigned into 7 groups: A (Oxytet.), B (IN - PPRVc), C (IN-PPRVc + Oxytet.), D (SC-PPRVc), E (SC-PPRVc + Oxytet.), F (Infected, untreated control), and G (Normal control). Natural PPRV infection was induced by the co-habitation method and following the onset of pyrexia in 75% of the goats, the interventions were administered accordingly. The leukocytic profiles were evaluated on days 1, 3, 5, 7 and 14 post-intervention (p.in). The clinical scores (CS), mortality pattern, lung lesion scores (LLS) and pathology were also evaluated post-intervention. A survivabilty score of 50% was observed in groups C and E with clinical scores of 2.06 and 3.90, while 100% mortality was recorded in the other groups with clinical scores of 4.38, 5.89, 7.05 and 6.92, for groups A, B, D and F, respectively. A mild decrease in the total leukocyte counts and absolute lymphocytes counts was observed in all the PPRV exposed groups by day 3 through 5 p.in but increased significantly (p<0.05) in groups C and E by day 14 p.in. Also, groups C and E showed the least mean (s.e.m) lung lesion scores of 0.61(0.12) and 0.64(0.15), respectively and also showed a relatively normal pulmonary, illeal, splenic and lymph node histomorphology, compared to the other groups. Postexposure PPR vaccination with concurrent oxytetracycline therapy significantly altered the known clinicopathology of PPR in goats, mitigated the disease severity and resulted in higher survivability in natural PPR infection.
COORDENAÇÃO PEDAGÓGICA EM TEMPOS DE CRISE NA EDUCAÇÃO ESCOLAR
Authors: PINHEIRO FERNANDES ELIANE 
Published: September 2024

O presente texto versa sobre os desafios da atividade do coordenador pedagógico escolar, sobretudo como articulador da formação docente continuada em serviço. Tem como objetivo explicitar as relações entre a crise na educação e a reorganização do capital evidenciando que nem as dificuldades encontradas no cotidiano escolar para o desempenho da atividade pedagógica, nem os apelos à formação docente continuada são neutros. Tanto a precarização da educação pública (incluídos os cursos de formação inicial, as condições de trabalho, os problemas crônicos da educação básica) como as pretensas soluções ofertadas pelos empresários da educação tem suas raízes na agudização da crise estrutural do capital. Como consequência, a função essencial da coordenação pedagógica tem sido esvaziada e alienada. Apresentamos como proposição a práxis do coordenador pedagógico da perspectiva da Trans-Formação que tem no imediato a busca por caminhos de superação por meio da luta por políticas públicas de defesa da educação básica totalmente estatal, da construção da práxis como prática-crítica orientada pela ciência da educação e, no horizonte, a emancipação humana.