bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rifampicin treatment of canine pyoderma due to multidrug‐resistant meticillin‐resistant staphylococci: a retrospective study of 32 cases
Authors: De Lucia Michela , Bardagi Mar , Fabbri Elisabetta , Ferreira Diana , Ferrer Lluis , Scarampella Fabia , Zanna Giordana , Fondati Alessandra 
Published: December 2016

BackgroundRifampicin has received increased interest in veterinary dermatology because of its activity against multidrug‐resistant meticillin‐resistant staphylococci (MRS). There is limited knowledge about the efficacy and safety of rifampicin in dogs.Hypothesis/ObjectiveTo provide information on response to treatment and adverse effects in dogs treated with rifampicin for multidrug‐resistantMRSpyoderma.AnimalsThirty two dogs treated with rifampicin for rifampicin‐susceptible multidrug‐resistantMRSpyoderma.MethodsRetrospective review of medical records, including alanine aminotransferase (ALT) and alkaline phosphatase (ALP) serum activity levels and total bilirubin concentrations, obtained before and throughout the treatment, was performed.ResultsOral rifampicin as sole systemic antimicrobial therapy (median dose 5 mg/kg twice daily) was effective in 71.88% of cases. Topical antimicrobials were used in most cases. Median duration of rifampicin treatment was five weeks for superficial pyoderma and four weeks for deep pyoderma. Gastrointestinal signs were reported in 15% of treated dogs. Statistically significant increases ofALT(P= 0.045) andALP(P= 0.0002) values after 3–4 weeks of treatment was observed. The median increase was equal to 0.3 and ×1.5 the upper limit of the reference ranges forALTandALP, respectively.Conclusions/Clinical importanceOral rifampicin combined with topical antimicrobials can be considered an effective therapeutic option for canine superficial and deep pyoderma caused by rifampicin‐susceptible multidrug‐resistantMRS. Liver enzyme induction might be the most important cause ofALTandALPincrease associated with rifampicin therapy in dogs.
Strong edge-coloring of subcubic planar graphs
Authors: Bu Yuehua , Zhu Hongguo 
Published: December 2016

A strong[Formula: see text]-edge-coloring of a graph [Formula: see text] is a mapping [Formula: see text]: [Formula: see text], such that [Formula: see text] for every pair of distinct edges at distance at most two. The strong chromatical index of a graph [Formula: see text] is the least integer [Formula: see text] such that [Formula: see text] has a strong-[Formula: see text]-edge-coloring, denoted by [Formula: see text]. In this paper, we prove [Formula: see text] for any subcubic planar graph with [Formula: see text] and [Formula: see text]-cycles are not adjacent to [Formula: see text]-cycles.
A Randomised Controlled Trial of Efficacy of Cognitive Rehabilitation in Multiple Sclerosis: A Cognitive, Behavioural, and MRI Study
Authors: Campbell J. , Langdon D. , Cercignani M. , Rashid W. 
Published: December 2016

Aim. To explore the efficacy of home-based, computerised, cognitive rehabilitation in patients with multiple sclerosis using neuropsychological assessment and advanced structural and functional magnetic resonance imaging (fMRI). Methods. 38 patients with MS and cognitive impairment on the Brief International Cognitive Assessment for MS (BICAMS) were enrolled. Patients were randomised to undergo 45 minutes of computerised cognitive rehabilitation using RehaCom software (n=19) three times weekly for six weeks or to a control condition (n=19). Neuropsychological and MRI data were obtained at baseline (time 1), following the 6-week intervention (time 2), and after a further twelve weeks (time 3). Cortical activations were explored using fMRI and microstructural changes were explored using quantitative magnetisation transfer (QMT) imaging. Results. The treatment group showed a greater improvement in SDMT gain scores between baseline and time 2 compared to the control group (p=0.005). The treatment group exhibited increased activation in the bilateral prefrontal cortex and right temporoparietal regions relative to control group at time 3 (p<0.05FWE  corrected). No significant changes were observed on QMT. Conclusion. This study supports the hypothesis that home-based, computerised, cognitive rehabilitation may be effective in improving cognitive performance in patients with MS. Clinical trials registration is ISRCTN54901925.
A Call for New Approaches to Quantifying Biases in Observations of Sea Surface Temperature
Authors: Kent Elizabeth C. , Kennedy John J. , Smith Thomas M. , Hirahara Shoji , Huang Boyin , Kaplan Alexey , Parker David E. , Atkinson Christopher P. , Berry David I. , Carella Giulia , Fukuda Yoshikazu , Ishii Masayoshi , Jones Philip D. , Lindgren Finn , Merchant Christopher J. , Morak-Bozzo Simone , Rayner Nick A. , Venema Victor , Yasui Souichiro , Zhang Huai-Min 
Published: December 2016

Abstract
Global surface temperature changes are a fundamental expression of climate change. Recent, much-debated variations in the observed rate of surface temperature change have highlighted the importance of uncertainty in adjustments applied to sea surface temperature (SST) measurements. These adjustments are applied to compensate for systematic biases and changes in observing protocol. Better quantification of the adjustments and their uncertainties would increase confidence in estimated surface temperature change and provide higher-quality gridded SST fields for use in many applications.
Bias adjustments have been based on either physical models of the observing processes or the assumption of an unchanging relationship between SST and a reference dataset, such as night marine air temperature. These approaches produce similar estimates of SST bias on the largest space and time scales, but regional differences can exceed the estimated uncertainty. We describe challenges to improving our understanding of SST biases. Overcoming these will require clarification of past observational methods, improved modeling of biases associated with each observing method, and the development of statistical bias estimates that are less sensitive to the absence of metadata regarding the observing method.
New approaches are required that embed bias models, specific to each type of observation, within a robust statistical framework. Mobile platforms and rapid changes in observation type require biases to be assessed for individual historic and present-day platforms (i.e., ships or buoys) or groups of platforms. Lack of observational metadata and high-quality observations for validation and bias model development are likely to remain major challenges.
Intraseasonal Periodicity in the Southern Hemisphere Circulation on Regional Spatial Scales
Authors: Thompson David W. J. , Crow Brian R. , Barnes Elizabeth A. 
Published: December 2016

Abstract
Wave activity in the Southern Hemisphere extratropical atmosphere exhibits robust periodicity on time scales of ~20–25 days. Previous studies have demonstrated the robustness of the periodicity in hemispheric averages of various eddy quantities. Here the authors explore the signature of the periodicity on regional spatial scales.
Intraseasonal periodicity in the Southern Hemisphere circulation derives from out-of-phase anomalies in wave activity that form in association with extratropical wave packets as they propagate to the east. In the upper troposphere, the out-of-phase anomalies in wave activity form not along the path of extratropical wave packets, but in their wake. The out-of-phase anomalies in wave activity give rise to periodicity not only on hemispheric scales, but also on synoptic scales when the circulation is sampled along an eastward path between ~5 and 15 m s−1. It is argued that 1) periodicity in extratropical wave activity derives from two-way interactions between the heat fluxes and baroclinicity in the lower troposphere and 2) the unique longitude–time structure of the periodicity in upper-tropospheric wave activity derives from the contrasting eastward speeds of the source of the periodicity in the lower troposphere (~10 m s−1) and wave packets in the upper troposphere (~25 m s−1).
On Tidal Inference in the Diurnal Band
Authors: Ray R. D. 
Published: December 2016

AbstractStandard methods of tidal inference should be revised to account for a known resonance that occurs mostly within the K1 tidal group in the diurnal band. The resonance arises from a free rotational mode of Earth caused by the fluid core. In a set of 110 bottom-pressure tide stations, the amplitude of the P1 tidal constituent is shown to be suppressed relative to K1, which is in good agreement with the resonance theory. Standard formulas for the K1 nodal modulation remain essentially unaffected. Two examples are given of applications of the refined inference methodology: one with monthly tide gauge data and one with satellite altimetry. For some altimeter-constrained tide models, an inferred P1 constituent is found to be more accurate than a directly determined one.
Genomics of chronic neutrophilic leukemia
Authors: Maxson Julia E. , Tyner Jeffrey W. 
Published: December 2016

Abstract
Chronic neutrophilic leukemia (CNL) is a distinct myeloproliferative neoplasm with a high prevalence (>80%) of mutations in the colony-stimulating factor 3 receptor (CSF3R). These mutations activate the receptor, leading to the proliferation of neutrophils that are a hallmark of CNL. Recently, the World Health Organization guidelines have been updated to include CSF3R mutations as part of the diagnostic criteria for CNL. Because of the high prevalence of CSF3R mutations in CNL, it is tempting to think of this disease as being solely driven by this genetic lesion. However, recent additional genomic characterization demonstrates that CNL has much in common with other chronic myeloid malignancies at the genetic level, such as the clinically related diagnosis atypical chronic myeloid leukemia. These commonalities include mutations in SETBP1, spliceosome proteins (SRSF2, U2AF1), and epigenetic modifiers (TET2, ASXL1). Some of these same mutations also have been characterized as frequent events in clonal hematopoiesis of indeterminate potential, suggesting a more complex disease evolution than was previously understood and raising the possibility that an age-related clonal process of preleukemic cells could precede the development of CNL. The order of acquisition of CSF3R mutations relative to mutations in SETBP1, epigenetic modifiers, or the spliceosome has been determined only in isolated case reports; thus, further work is needed to understand the impact of mutation chronology on the clonal evolution and progression of CNL. Understanding the complete landscape and chronology of genomic events in CNL will help in the development of improved therapeutic strategies for this patient population.
Inter-rater reliability of mini balance evaluation system test in ambulatory people with multiple sclerosis
Authors: Ross Elaine , Purtill Helen , Coote Susan 
Published: December 2016

Background: Balance deficits are common in people with multiple sclerosis, and accurate measurement of balance using clinical measures is important. This study investigates the inter-rater reliability of the mini Balance Evaluation System test (mini-BESTest) in ambulatory people with multiple sclerosis. Methods: People with multiple sclerosis attending physiotherapy in an acute hospital were invited to take part. Participants gave demographic information and completed the mini-BESTest twice. Raters were experienced and novice physiotherapists. Data were analysed using intraclass correlation coefficients and Bland and Altman analysis. Agreement of individual items were analysed using weighted Kappa. Results: Fifty participants (37 female) had a mean age of 45.73 (5.65) years; 61.5% did not use a walking aid. The mean difference between the raters was 0.27 (Standard deviation: 1.8; 95% confidence interval (CI): -2.5+2.02), which was not significantly different (P=0.816). The intra class correlation coefficient was 0.98 (95% CI: 0.96–0.99). The standard error of the measures was 1.27, with a minimum detectable change of 3.91. Most items (2–4, 7–10, 12–14) on the mini-BESTest had Kappa values greater than 0.51; item 14 demonstrated complete agreement (k=1). Percentage agreement for individual questions ranged from 69% to 100%. Conclusions: Agreement between raters was high for the total score and for the majority of individual items. A change greater than 3.9 points on the mini-BESTest is required to be confident that change is not due to measurement error when two raters are used.
Effects of bilateral flexible flatfoot on trunk and hip muscles' torque
Authors: Zahran Samah Saad , Aly Sobhy M , Zaky Lilian Albert 
Published: December 2016

Background: Flexible flatfoot has been considered as a risk factor for a number of lower limb injuries and mechanical low back pain. This, theoretically, was attributed to dysfunction of the lumbopelvic-hip complex musculature. Despite this theoretical basis, no study has evaluated the effect of flexible flatfoot on the strength of the lumbar and hip muscles. Objective: To investigate the influence of flexible flatfoot on concentric hip and trunk torque generation. Methods: A case-control comparison was held between a flexible flatfoot group (20 subjects) and a normal foot group (20 subjects). An isokinetic dynamometer was used to assess the concentric torque of hip flexors, extensors, internal rotators, and external rotators; and trunk flexors, and extensors. Group differences were assessed by using a one-way multivariate analysis of variance. Results: There was a significant decrease in the hip flexors', extensors', internal rotators', and external rotators' peak torque of both sides in the flexible flatfoot group compared to the normal group, while there was no significant difference in the lumbar flexors' and extensors' peak torque between the two groups. Conclusion: Impairment in hip muscles' concentric strength was observed in subjects with flexible flatfoot when compared to normal controls. Our results may support the interrelationship between foot misalignment and proximal joints pathology.
EDITORAS DE PERIÓDICOS PREDADORES: UM PERIGO NA DIVULGAÇÃO DE RESULTADOS DE PESQUISA NO BRASIL E NO MUNDO
Authors: Oliveira Anselmo Gomes de , Silveira Dâmaris 
Published: December 2016

Desde os últimos 30 anos, além dos periódicos científicos impressos e de acesso restrito, que são mantidos por meio de assinaturas ou por sociedades científicas, surgiram outros periódicos, impressos e/ou online,em sua grande maioria de acesso livre, que para sua manutençãocobram dos autores interessados na publicação. Assim, o autor é solicitado a pagar taxa para submissão de artigos, taxas de editoração, taxas para manutenção on line, taxas para visualização completa do artigo on line, ou, as mais comuns, taxas para a publicação, os quais na maioria das vezes são de acervo aberto. Ou seja, instituições de pesquisa do mundo todo ou devem pagar taxas anuais para ter acesso aos artigos científicos, muitasvezes de autoria de seus próprios pesquisadores, ou pela publicação dos artigos de seus pesquisadores.
PSEUDOMONAS AERUGINOSA EM HOSPITAL DA MICRORREGIÃO DE OURO PRETO, MINAS GERAIS, BRASIL
Authors: Bianco de Souza Gustavo Henrique , Rezende Miranda Renata , De Jesus Inácio Luciana , Roquete Amparo Tatiane , Araújo Vaz Luana Beatriz , Silva Fernades Maísa Angélica , De Carvalho Mapa Bruna , Medeiros Teixeira Luiz Fernando , Gomes Assenço Regina Aparecida , Da Silva Lanna Maria Célia , Santos Silva Alessandra Júlia , De Castro Campos Marcela Maria , Pedrosa da Fonseca Rios Elisa Maria 
Published: December 2016

A água representa o principal meio de transmissão de micro-organismos em centros de saúde, os quais podem causar infecções que são um grave problema de saúde pública. O objetivo desse estudo foi avaliar a qualidade microbiológica da água utilizada em um hospital da microrregião de Ouro Preto, Minas Gerais, Brasil. Foram coletadas doze amostras de água em pontos distintos para testes de detecção de coliformes totais e termotolerantes, assim como de outros microrganismos; além disso, testes de sensibilidade a antimicrobianos também foram realizados. A espécie bacteriana Pseudomonas aeruginosa foi detectada na amostra correspondente à água de enxágue de roupas limpas coletada na área limpa da lavanderia e foi identificada por coloração de Gram e análise automatizada utilizando o equipamento VITEK®. O isolado de P.aeruginosa mostrou-se sensível aos antibióticos usualmente utilizados no tratamento de infecções induzidas por esta bactéria, tais como cefalosporinas, fluorquinolonas, polimixinas e carbapenêmicos. Contudo, os resultados indicam a necessidade de maior atenção ao processo de higienização de roupas hospitalares, fato ainda negligenciado no Brasil.
ALTERAÇÕES NO HEMOGRAMA DE PACIENTES COM DENGUE NO MUNICÍPIO DE SÃO JOSÉ DO CALÇADO, ES, BRASIL
Authors: Faria Ronaldo Jose , Bazoni Patricia Silva 
Published: December 2016

A dengue é uma doença viral que vem se tornando um dos principais problemas de saúde pública no mundo. No Brasil, a infecção pelo vírus da dengue se torna cada vez mais frequente, atingindo a população de todos os Estados. O presente estudo teve como objetivo identificar e descrever a frequência das alterações do hemograma de pacientes que apresentaram sorologia IgM positiva para dengue. Entre janeiro e abril de 2016 foram notificados 656 pacientes com suspeita da doença. Destes, 498 pacientes apresentaram sorologia IgM positiva. Trata-se de um estudo retrospectivo descritivo, seguido de uma análise crítica dos dados do hemograma destes pacientes para obtenção da frequência das alterações hematológicas. Dentre os casos estudados a população feminina foi a mais acometida pela doença, tendo 52 % de prevalência. No que tange à faixa etária, indivíduos com mais de 50 anos foram os mais atingidos com 35,5 % de prevalência. As alterações hematológicas mais observadas foram leucopenia, que esteve presente em 57,7 % dos pacientes, seguido de plaquetopenia predominante em 32,0 % dos casos, linfopenia em 21,7 % e aumento do hematócrito (HCT) em 14,8 %. Fatores como a genética viral e a resposta imune diferenciada entre os pacientes, faz com que a frequência dessas alterações varie de acordo com a região e a população estudada. A realização do hemograma é de suma importância, devido sua grande contribuição para a decisão da conduta médica frente à ocorrência de possíveis casos críticos da doença.
ANÁLISE DO CONTEÚDO DAS INFORMAÇÕES TECNICO-CIENTÍFICAS DE FOLDERS PUBLICITARIOS DE ATIVOS MAGISTRAIS
Authors: Robles Ana Claudia Tomaz , Almeida Rosane Lopes de , Tiyo Rogerio , Lopes Gisely Cristiny 
Published: December 2016

O setor magistral, a partir da lei dos medicamentos genéricos, teve uma grande expansão no Brasil, e passou a manipular inúmeros fármacos, cujas apresentações farmacêuticas são disponibilizadas pela indústria farmacêutica, com apresentações em dose individualizadas. além daqueles voltados à dermatologia e à homeopatia. Com o aumento do número de farmácias de manipulação no Brasil e devido à sua competitividade, surgiu a necessidade de divulgação de produtos e preços, que levaram a estratégias, para a promoção dos produtos e serviços. O objetivo deste trabalho foi analisar a linguagem publicitária, utilizada por empresas fornecedoras de matérias-primas para o setor magistral. Nos casos analisados, as imagens utilizadas para a promoção dos ativos magistrais nas peças publicitárias, de modo geral, são apelativas, usadas para causar impacto sobre o consumidor, de tal modo que influenciem a sua decisão de compra. As estratégias utilizadas pelo marketing foram figuras humanas, confrontando o antes e o depois. Essas imagens geralmente divulgam produtos voltados para o tratamento da obesidade, “peeling” facial, tratamento de cicatrizes, queda de cabelos. Os resultados do presente estudo sugerem que a publicidade dos produtos avaliados usou estratégias de marketing que estimulam o desejo do consumidor. Neste contexto, o uso das imagens femininas foi a estratégia da propaganda, em detrimento das informações sobre a eficácia e segurança do produto.
The Migration Crisis as It Seems: Speech Manipulation Technology in US Internet Media
Authors: Nikitina Ksenia 
Published: December 2016

Abstract
The following paper is devoted to the study of speech manipulation technologies in US political media discourse. A number of web-based articles have been taken under consideration for this study. They demonstrate the problem arising from the refugee flow in Europe and create a special “image” of the complicated European situation. It is helpful to see how the situation appears in the Internet media since this type of mass communication is most influential these days. While considering a large amount of media texts, a special speech manipulation technology has been revealed. This phenomenon demonstrates a distinct structure and close interrelations of purposefully selected elements. Going through a number of stages we can find out the technology of speech manipulation – a system of using the aggregate of speech manipulation instruments in order to purposefully guide the reality perception of the mass audience. The external level of the texts enables us to take a penetrating look at the internal intentions. This knowledge will help us not to confuse the migration crisis as it is and the migration crisis as it seems.
Influence of Tin Bronze Melting and Pouring Parameters on Its Properties and Bells’ Tone
Authors: Bartocha D. , Baron C. 
Published: December 2016

Abstract
The most important feature of bells is their sound. Its clarity and beauty depend, first of all, on the bell’s geometry - particularly the shape of its profile, but also on the quality of alloy used to its cast. Hence, if the melting and pouring parameters could influence the alloy’s properties, what influence they would have on the frequencies of bell’s tone. In the article authors present their own approaches to find answers on that and more questions.
Determining the Degree of Removal of Copper From Slag
Authors: Bydałek A.W. , Migas P. , Wołczyński W. , Biernat S. , Bydałek A. , Jasińska K. , Kwapisiński P. 
Published: December 2016

Abstract
The scope of work included the launch of the process of refining slag suspension in a gas oven using a variety of technological additives. After the refining process (in the context of copper recovery), an assessment of the effect of selected reagents at the level of the slag refining suspension (in terms of copper recovery). Method sieve separated from the slag waste fraction of metallic, iron - silicate and powdery waste. Comparison of these photographs macroscopic allowed us to evaluate the most advantageous method of separating metallic fraction from the slag. After applying the sample A (with KF2 + NaCl) we note that in some parts of the slag are still large amounts of metallic fraction. The fraction of slag in a large majority of the elements has the same size of 1 mm, and a larger portion of the slag, the size of which is from 2 to 6 mm. Definitely the best way is to remove the copper by means of the component B (with NaCl) and D (with KF2). However, as a result of removing the copper by means of component C (with CaO) were also obtained a relatively large number of tiny droplets of copper, which was problematic during segregation. In both cases we were able to separate the two fractions in a fast and simple manner.