bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Give me some space”: exploring youth to parent aggression and violence
Authors: Gabriel Lynne , Tizro Zahra , James Hazel , Cronin-Davis Jane , Beetham Tanya , Corbally Alice , Lopez-Moreno Emily , Hill Sarah 
Published: October 2017

AbstractA small scale qualitative project, undertaken by an interdisciplinary domestic violence research group involving academic researchers and research assistants, with colleagues from Independent Domestic Abuse Services (IDAS), investigated youth aggression and violence against parents. Following the literature review, data was generated through several research conversations with young people (n = 2), through semi-structured interviews with mothers (n = 3) and practitioners (n = 5), and through a practitioner focus group (n = 8). Thematic analysis and triangulation of the data from parents, practitioners and young people, elicited interconnected and complex overarching themes. Young people could be both victim and perpetrator. The witnessing or experiencing of domestic aggression and violence raised the concept of ‘bystander children’. The impact of young people experiencing familial violence was underestimated by parents. For practitioners, the effects of working with domestic violence was shown to be significant - both positively and negatively.
HIGH SOIL CALCIUM SATURATION LIMITS USE OF LEAF POTASSIUM DIAGNOSIS WHEN KCL IS APPLIED IN OIL PALM PLANTATIONS
Authors: DUBOS BERNARD , BARON VICTOR , BONNEAU XAVIER , FLORI ALBERT , OLLIVIER JEAN 
Published: October 2017

SUMMARYPotassium chloride (KCl) is the most widely used fertilizer in oil palm (Elaeis guineensis) plantations and the rates applied are based on interpretation of leaf K contents. When no positive response on leaf K contents can be detected, no optimum content can be established whatever the yield response to KCl rates. We used data from 13 fertilization trials conducted on several continents to study the responses of leaf K, leaf Cl, leaf Ca and yield to KCl rates as a function of the soil properties of each site. We found that the abundance of exchangeable Ca in the soil expressed as a percent of the cation exchange capacity (CEC) was the best soil variable to predict if leaf K content would increase with KCl rates. In addition, we found that the leaf K contents of unfertilized controls at the end of the trials were also correlated with Ca/CEC. This ratio thus appears to be a better index of soil K reserves than soil exchangeable K content.
Acute LSD effects on response inhibition neural networks
Authors: Schmidt A. , Müller F. , Lenz C. , Dolder P. C. , Schmid Y. , Zanchi D. , Lang U. E. , Liechti M. E. , Borgwardt S. 
Published: October 2017

AbstractBackgroundRecent evidence shows that the serotonin 2A receptor (5-hydroxytryptamine2A receptor, 5-HT2AR) is critically involved in the formation of visual hallucinations and cognitive impairments in lysergic acid diethylamide (LSD)-induced states and neuropsychiatric diseases. However, the interaction between 5-HT2AR activation, cognitive impairments and visual hallucinations is still poorly understood. This study explored the effect of 5-HT2AR activation on response inhibition neural networks in healthy subjects by using LSD and further tested whether brain activation during response inhibition under LSD exposure was related to LSD-induced visual hallucinations.MethodsIn a double-blind, randomized, placebo-controlled, cross-over study, LSD (100 µg) and placebo were administered to 18 healthy subjects. Response inhibition was assessed using a functional magnetic resonance imaging Go/No-Go task. LSD-induced visual hallucinations were measured using the 5 Dimensions of Altered States of Consciousness (5D-ASC) questionnaire.ResultsRelative to placebo, LSD administration impaired inhibitory performance and reduced brain activation in the right middle temporal gyrus, superior/middle/inferior frontal gyrus and anterior cingulate cortex and in the left superior frontal and postcentral gyrus and cerebellum. Parahippocampal activation during response inhibition was differently related to inhibitory performance after placebo and LSD administration. Finally, activation in the left superior frontal gyrus under LSD exposure was negatively related to LSD-induced cognitive impairments and visual imagery.ConclusionOur findings show that 5-HT2AR activation by LSD leads to a hippocampal–prefrontal cortex-mediated breakdown of inhibitory processing, which might subsequently promote the formation of LSD-induced visual imageries. These findings help to better understand the neuropsychopharmacological mechanisms of visual hallucinations in LSD-induced states and neuropsychiatric disorders.
The advantage of story-telling: children's interpretation of reported speech in narratives
Authors: KÖDER FRANZISKA , MAIER EMAR 
Published: October 2017

AbstractChildren struggle with the interpretation of pronouns in direct speech (Ann said, “I get a cookie”), but not in indirect speech (Ann said that she gets a cookie) (Köder & Maier, 2016). Yet children's books consistently favor direct over indirect speech (Baker & Freebody, 1989). To reconcile these seemingly contradictory findings, we hypothesize that the poor performance found by Köder and Maier (2016) is due to the information-transmission setting of that experiment, and that a narrative setting facilitates children's processing of direct speech. We tested 42 Dutch children (4;1–7;2) and 20 adults with a modified version of Köder and Maier's referent selection task, where participants interpret speech reports in an interactive story book. Results confirm our hypothesis: children are much better at interpreting pronouns in direct speech in such a narrative setting than they were in an information-transmission setting. This indicates that the pragmatic context of reports affects their processing effort.
The potential contribution of yellow cassava to dietary nutrient adequacy of primary-school children in Eastern Kenya; the use of linear programming
Authors: Talsma Elise F , Borgonjen-van den Berg Karin J , Melse-Boonstra Alida , Mayer Eva V , Verhoef Hans , Demir Ayşe Y , Ferguson Elaine L , Kok Frans J , Brouwer Inge D 
Published: October 2017

AbstractObjectiveIntroduction of biofortified cassava as school lunch can increase vitamin A intake, but may increase risk of other deficiencies due to poor nutrient profile of cassava. We assessed the potential effect of introducing a yellow cassava-based school lunch combined with additional food-based recommendations (FBR) on vitamin A and overall nutrient adequacy using Optifood (linear programming tool).DesignCross-sectional study to assess dietary intakes (24 h recall) and derive model parameters (list of foods consumed, median serving sizes, food and food (sub)group frequency distributions, food cost). Three scenarios were modelled, namely daily diet including: (i) no school lunch; (ii) standard 5d school lunch with maize/beans; and (iii) 5d school lunch with yellow cassava. Each scenario and scenario 3 with additional FBR were assessed on overall nutrient adequacy using recommended nutrient intakes (RNI).SettingEastern Kenya.SubjectsPrimary-school children (n150) aged 7–9 years.ResultsBest food pattern of yellow cassava-based lunch scenario achieved 100 % RNI for six nutrients compared with no lunch (three nutrients) or standard lunch (five nutrients) scenario. FBR with yellow cassava and including small dried fish improved nutrient adequacy, but could not ensure adequate intake of fat (52 % of average requirement), riboflavin (50 % RNI), folate (59 % RNI) and vitamin A (49 % RNI).ConclusionsIntroduction of yellow cassava-based school lunch complemented with FBR potentially improved vitamin A adequacy, but alternative interventions are needed to ensure dietary adequacy. Optifood is useful to assess potential contribution of a biofortified crop to nutrient adequacy and to develop additional FBR to address remaining nutrient gaps.
War at sea: Nineteenth-century laws for twenty-first century wars?
Authors: Haines Steven 
Published: October 2017

AbstractWhile most law on the conduct of hostilities has been heavily scrutinized in recent years, the law dealing with armed conflict at sea has been largely ignored. This is not surprising. There have been few naval conflicts since 1945, and those that have occurred have been limited in scale; none has involved combat between major maritime powers. Nevertheless, navies have tripled in number since then, and today there are growing tensions between significant naval powers. There is a risk of conflict at sea. Conditions have changed since 1945, but the law has not developed in that time. Elements of it, especially that regulating economic warfare at sea, seem outdated and it is not clear that the law is well placed to regulate so-called “hybrid” warfare at sea. It seems timely to review the law, to confirm that which is appropriate and to develop that which is not. Perhaps a new edition of theSan Remo Manualwould be timely.
Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish
Authors: Srivastava Nidhi , Shelly Asha , Kumar Manmohan , Pant Archana , Das Bhabatosh , Majumdar Tanmay , Mazumder Shibnath 
Published: October 2017

AbstractToll-like receptor 4 (TLR4) plays a critical role in host immunity against Gram-negative bacteria. It transduces signals through two distinct TIR-domain-containing adaptors, MyD88 and TRIF, which function at the plasma membrane and endosomes, respectively. Using zebrafish Aeromonas hydrophila infection model, we demonstrate that synchronization of MyD88 and TRIF dependent pathways is critical for determining the fate of infection. Zebrafish were infected with A. hydrophila, and bacterial recovery studies suggested its effective persistence inside the host. Histopathological assessment elucidates that A. hydrophila did not provoke inflammatory responses in the spleen. Immunofluorescence revealed the presence of TLR4-bound A. hydrophila on the plasma membrane at 3 h post-infection (p.i.), and inside endosomes 1 day p.i. Quantitative PCR studies suggest that TLR4 activates the downstream pathway of MyD88–IRAK4 axis at early stages followed by a shift to TRIF–TRAF6 axis at late stages of infection coupled with fold increase in NFκB. Our results implicated the involvement of p110δ isoform of PI(3)Kinase in this transition. Coupled to this, we noted that the TLR4–TRIF–NFκB axis prompted burgeoned secretion of anti-inflammatory cytokines. We observed that A. hydrophila inhibits endosome maturation and escapes to cytoplasm. Significant downregulation of cytosolic-NLR receptors further suggested that A. hydrophila represses pro-inflammatory responses in cytosol aiding its persistence. Our findings suggest a novel role of ‘TLR4 topology’ in A. hydrophila-induced pathogenesis. We propose that A. hydrophila manipulates translocation of TLR4 and migrates to endosome, where it triggers TRIF-dependent anti-inflammatory responses, interferes with endosomal maturation and escapes to cytosol. Inside the cytosol, A. hydrophila avoids detection by suppressing NLRs, facilitating its survival and ensuing pathogenesis.
Combination curcumin and (−)-epigallocatechin-3-gallate inhibits colorectal carcinoma microenvironment-induced angiogenesis by JAK/STAT3/IL-8 pathway
Authors: Jin G , Yang Y , Liu K , Zhao J , Chen X , Liu H , Bai R , Li X , Jiang Y , Zhang X , Lu J , Dong Z 
Published: October 2017

AbstractTumor microenvironment has a crucial role in cancer development and progression, whereas the mechanism of how it regulates angiogenesis is unclear. In this study, we simulated the colorectal carcinoma microenvironment by conditioned medium (CM) of colorectal carcinoma cell lines (SW620, HT-29, HCT116) supernatant or colorectal carcinoma tissue homogenate supernatant to induce normal endothelial cells (NECs). We found that colorectal carcinoma CM promoted tumor angiogenesis by coercing NECs toward tumor endothelial cells (TECs) with the activation of the JAK/STAT3 signaling pathway. Antibody array analysis showed HT-29 supernatant contained numerous angiogenesis-related proteins, especially IL-8. Interestingly, the production of IL-8 in NECs induced by HT-29 CM was also increased. We also verified the crucial role of IL-8 in promoting the CM-induced angiogenesis, as IL-8 repression by neutralizing antibody abolished the transition of NECs toward TECs. Curcumin and (−)-epigallocatechin-3-gallate (EGCG) are broadly investigated in cancer chemoprevention. However, poor bioavailability hurdles their application alone, and the mechanism of their anti-angiogenesis still need to be illuminated. Here, we found that curcumin combination with EGCG attenuated the tumor CM-induced transition of NECs toward TECs by inhibiting JAK/STAT3 signaling pathway. Furthermore, the combination of curcumin and EGCG markedly reduced tumor growth and angiogenesis in the colorectal carcinoma PDX mouse model, and the combined anti-angiogenic effect was better than that of curcumin or EGCG alone. Taken together, our findings provide a new mechanism of tumor angiogenesis, and the combination of curcumin and EGCG represents a potential anti-angiogenic therapeutic method for colorectal carcinoma.
Synchronized conductivity modulation to realize broadband lossless magnetic-free non-reciprocity
Authors: Dinc Tolga , Tymchenko Mykhailo , Nagulu Aravind , Sounas Dimitrios , Alu Andrea , Krishnaswamy Harish 
Published: October 2017

AbstractRecent research has explored the spatiotemporal modulation of permittivity to break Lorentz reciprocity in a manner compatible with integrated-circuit fabrication. However, permittivity modulation is inherently weak and accompanied by loss due to carrier injection, particularly at higher frequencies, resulting in large insertion loss, size, and/or narrow operation bandwidths. Here, we show that the presence of absorption in an integrated electronic circuit may be counter-intuitively used to our advantage to realize a new generation of magnet-free non-reciprocal components. We exploit the fact that conductivity in semiconductors provides a modulation index several orders of magnitude larger than permittivity. While directly associated with loss in static systems, we show that properly synchronized conductivity modulation enables loss-free, compact and extremely broadband non-reciprocity. We apply these concepts to obtain a wide range of responses, from isolation to gyration and circulation, and verify our findings by realizing a millimeter-wave (25 GHz) circulator fully integrated in complementary metal-oxide-semiconductor technology.
Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism
Authors: Antoniali Giulia , Serra Fabrizio , Lirussi Lisa , Tanaka Mikiei , D’Ambrosio Chiara , Zhang Shiheng , Radovic Slobodanka , Dalla Emiliano , Ciani Yari , Scaloni Andrea , Li Mengxia , Piazza Silvano , Tell Gianluca 
Published: October 2017

AbstractMammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxidative stress responses, tumor progression and chemoresistance. However, the molecular mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still unclear. Recent findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism. Through the characterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and stability via association with the DROSHA-processing complex during genotoxic stress. We also show that endonuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the processing of miR-221/222 in regulating expression of the tumor suppressor PTEN. Analysis of a cohort of different cancers supports the relevance of our findings for tumor biology. We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA-interactomes and protein-interactomes involved in cancer development, thus indicating an unsuspected post-transcriptional effect on cancer genes.
Predicting the effect of habitat modification on networks of interacting species
Authors: Staniczenko Phillip P. A. , Lewis Owen T. , Tylianakis Jason M. , Albrecht Matthias , Coudrain Valérie , Klein Alexandra-Maria , Reed-Tsochas Felix 
Published: October 2017

AbstractA pressing challenge for ecologists is predicting how human-driven environmental changes will affect the complex pattern of interactions among species in a community. Weighted networks are an important tool for studying changes in interspecific interactions because they record interaction frequencies in addition to presence or absence at a field site. Here we show that changes in weighted network structure following habitat modification are, in principle, predictable. Our approach combines field data with mathematical models: the models separate changes in relative species abundance from changes in interaction preferences (which describe how interaction frequencies deviate from random encounters). The models with the best predictive ability compared to data requirement are those that capture systematic changes in interaction preferences between different habitat types. Our results suggest a viable approach for predicting the consequences of rapid environmental change for the structure of complex ecological networks, even in the absence of detailed, system-specific empirical data.
Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration
Authors: Gordon-Alonso Monica , Hirsch Thibault , Wildmann Claude , van der Bruggen Pierre 
Published: October 2017

AbstractThe presence of T cells in tumors predicts overall survival for cancer patients. However, why most tumors are poorly infiltrated by T cells is barely understood. T-cell recruitment towards the tumor requires a chemokine gradient of the critical IFNγ-induced chemokines CXCL9/10/11. Here, we describe how tumors can abolish IFNγ-induced chemokines, thereby reducing T-cell attraction. This mechanism requires extracellular galectin-3, a lectin secreted by tumors. Galectins bind the glycans of glycoproteins and form lattices by oligomerization. We demonstrate that galectin-3 binds the glycans of the extracellular matrix and those decorating IFNγ. In mice bearing human tumors, galectin-3 reduces IFNγ diffusion through the tumor matrix. Galectin antagonists increase intratumoral IFNγ diffusion, CXCL9 gradient and tumor recruitment of adoptively transferred human CD8+T cells specific for a tumor antigen. Transfer of T cells reduces tumor growth only if galectin antagonists are injected. Considering that most human cytokines are glycosylated, galectin secretion could be a general strategy for tumor immune evasion.
The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age
Authors: Hosokawa Kentaro , MacArthur Ben D. , Ikushima Yoshiko Matsumoto , Toyama Hirofumi , Masuhiro Yoshikazu , Hanazawa Shigemasa , Suda Toshio , Arai Fumio 
Published: October 2017

AbstractRepeated cell divisions and aging impair stem cell function. However, the mechanisms by which this occurs are not fully understood. Here we show that protection of telomeres 1A (Pot1a), a component of the Shelterin complex that protects telomeres, improves haematopoietic stem cell (HSC) activity during aging. Pot1a is highly expressed in young HSCs, but declines with age. In mouse HSCs, Pot1a knockdown increases DNA damage response (DDR) and inhibits self-renewal. Conversely, Pot1a overexpression or treatment with POT1a protein prevents DDR, maintained self-renewal activity and rejuvenated aged HSCs upon ex vivo culture. Moreover, treatment of HSCs with exogenous Pot1a inhibits the production of reactive oxygen species, suggesting a non-telomeric role for Pot1a in HSC maintenance. Consistent with these results, treatment with exogenous human POT1 protein maintains human HSC activity in culture. Collectively, these results show that Pot1a/POT1 sustains HSC activity and can be used to expand HSC numbers ex vivo.
Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria
Authors: Mebratu Yohannes A. , Leyva-Baca Ivan , Wathelet Marc G. , Lacey Neal , Chand Hitendra S. , Choi Augustine M. K. , Tesfaigzi Yohannes 
Published: October 2017

AbstractBik reduces hyperplastic epithelial cells by releasing calcium from endoplasmic reticulum stores and causing apoptosis, but the detailed mechanisms are not known. Here we report that Bik dissociates the Bak/Bcl-2 complex to enrich for ER-associated Bak and interacts with the kinase domain of DAPk1 to form Bik–DAPk1–ERK1/2–Bak complex. Bik also disrupts the Bcl2–IP3R interaction to cause ER Ca2+ release. The ER-associated Bak interacts with the kinase and calmodulin domains of DAPk1 to increase the contact sites of ER and mitochondria, and facilitate ER Ca2+ uptake by mitochondria. Although the Bik BH3 helix was sufficient to enrich for ER-Bak and elicit ER Ca2+ release, Bik-induced mitochondrial Ca2+ uptake is blocked with reduced Bak levels. Further, the Bik-derived peptide reduces allergen- and cigarette smoke-induced mucous cell hyperplasia in mice and in differentiated primary human airway epithelial cultures. Therefore, Bik peptides may have therapeutic potential in airway diseases associated with chronic mucous hypersecretion.
A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease
Authors: Ren Yue , Sekine-Kondo Etsuko , Shibata Risa , Kato-Itoh Megumi , Umino Ayumi , Yanagida Ayaka , Satoh Masashi , Inoue Komaki , Yamaguchi Tomoyuki , Mochida Keiichi , Nakae Susumu , Van Kaer Luc , Iwabuchi Kazuya , Nakauchi Hiromitsu , Watarai Hiroshi 
Published: October 2017

AbstractiNKT cells play important roles in immune regulation by bridging the innate and acquired immune systems. The functions of iNKT cells have been investigated in mice lacking the Traj18 gene segment that were generated by traditional embryonic stem cell technology, but these animals contain a biased T cell receptor (TCR) repertoire that might affect immune responses. To circumvent this confounding factor, we have generated a new strain of iNKT cell-deficient mice by deleting the Traj18 locus using CRISPR/Cas9 technology, and these animals contain an unbiased TCR repertoire. We employed these mice to investigate the contribution of iNKT cells to metabolic disease and found a pathogenic role of these cells in obesity-associated insulin-resistance. The new Traj18-deficient mouse strain will assist in studies of iNKT cell biology.
Generation of micro-droplet arrays by dip-coating of biphilic surfaces; the dependence of entrained droplet volume on withdrawal velocity
Authors: Mandsberg Nikolaj Kofoed , Hansen Ole , Taboryski Rafael 
Published: October 2017

AbstractDroplet array chips were realized using an alignment-free fabrication process in silicon. The chips were textured with a homogeneous nano-scale surface roughness but were partially covered with a self-assembled monolayer of perfluorodecyltrichlorosilane (FDTS), resulting in a super-biphilic surface. When submerged in water and withdrawn again, microliter sized droplets are formed due to pinning of water on the hydrophilic spots. The entrained droplet volumes were investigated under variation of spot size and withdrawal velocity. Two regimes of droplet formation were revealed: at low speeds, the droplet volume achieved finite values even for vanishing speeds, while at higher speeds the volume was governed by fluid inertia. A simple 2D boundary layer model describes the behavior at high speeds well. Entrained droplet volume could be altered, post-fabrication, by more than a factor of 15, which opens up for more applications of the dip-coating technique due to the significant increase in versatility of the micro-droplet array platform.