bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iron Deficiency and its Relationship with Chronic Heart Failure- A Review
Authors: Kaur Arshdeep , Kumar Ranjeet 
Published: September 2024

Abstract:
Iron Deficiency (ID) is common in patients with cardiovascular disease. More than 64
million patients are suffering from chronic heart failure. The prevalence of iron deficiency increases
with the severity of cardiac and renal dysfunction and is probably more common amongst women.
Aim: This review article discusses multifactorial pathophysiology, the relationship between
clinical characteristics, functional and absolute ID, and the advantages of medicinal intervention
in chronic heart failure (CHF). It also covers how iron shortage affects other body parts. Approach:
The most recent publications that included substantial scientific data on the connection between
CHF and ID, with or without anaemia, were selected. Discussion: Complex physiopathological
interactions, including higher hepcidin levels, systemic inflammation, and activation of the
renin-angiotensin-aldosterone system, have been identified in these patients. These mechanisms
exacerbate the outcomes for patients by amplifying the severity of anemia, chronic heart failure
(CHF), and Chronic kidney disease (CKD). Research in this area has been limited and has shown
inconsistent findings. Still, it has also examined evidence-based treatment approaches and diagnostic
guidelines, especially in relation to iron supplements and erythropoietin-stimulating medications.
Conclusion: Anemia is a frequent chronic heart failure consequence and a poor prognostic
factor. We still don't completely understand the many complex causes of anemia. Iron deficiency
screening is highly recommended for people with cardiac ailments because of its significance for
their prognoses. Due to the paucity of research proving its effectiveness, the high incidence of unfavourable
gastrointestinal side effects, and the prolonged length of time required for treatment to
boost haemoglobin levels, an oral iron supplement is not advised for people with chronic heart failure.
An insufficient amount of iron not only impacts the heart but also various other body components.
Attention Deficit Hyperactivity Disorder Symptoms Among Students Attending Higher Educational Institution: A Cross-Sectional Study
Authors: Singh Sachitanand , Thakur Renu , Kumar Krishan , Dogra Ayush 
Published: September 2024

Background
A complicated and clinically varied illness known as ADHD (“Attention-deficit/hyperactivity disorder”) leads to poor academic and professional outcomes, family stress, and financial difficulty. Worldwide, children and adults with attention-deficit/hyperactivity disorder are likely to suffer from all problems. ADHD are neurodevelopmental diseases that impact impulsivity, hyperactivity, and inattention. Basic academic skills like reading and arithmetic have been connected to visual search and sustained visual attention.

Methodology
The prevalence of attention-deficit/hyperactivity symptoms among students aged 17 to 23 in higher education institutions in Punjab, India, was investigated through a cross-sectional quantitative survey conducted from May to September 2023.. An online form was used to create the ADHD self-report scale (v1.1). This questionnaire was divided into 3-part inattention, hyperactivity, and impulsivity. The responses were categorized into five levels: Never, Rarely, Sometimes, Often, and Very Often. This Questionnaire was distributed to students from higher educational institutes, and data was collected.

Result
The total 360 student data were analyzed using SPSS 20. As the age increased, ADHD symptoms were reduced, inattention was most symptomatic in 18 and 19 years,` and hyperactivity and impulsivity symptoms had high scores in the 23 years age category. Out of the participants, 228 were female and 132 were male. Female students exhibited more symptoms of inattention (37.7%), while male students showed higher symptoms of hyperactivity (39.4%) and impulsivity (31.8%). Most students reported experiencing symptoms 'sometimes,' with responses indicating 'often' or 'very often' being rare across all three categories. This suggests that many respondents experience ADHD-related symptoms. Factors such as the number of siblings, family type, parents’ education level, and living arrangements did not impact the prevalence of ADHD symptoms.

Conclusion
The prevalence rate of ADHD symptoms among north Indian higher educational institutes was 23.3%. Among these ADHD-symptomatic students, inattention was 35%, hyperactivity 39.2%, and Impulsivity 26.9%, respectively.
Quinoline Derivative Green Synthesis: Unveiling Anticancer Potential through Synergistic Insights and Molecular Docking Analysis
Authors: Manvar Parth , Vyas Amita , Katariya Dharmesh , Khedkar Vijay , Khunt Ranjan 
Published: September 2024

Aim:
Synthesis and characterization of quinoline derivatives as an anticancer agent via
green chemistry approach and their molecular docking.

Background:
In comparison to classical synthesis, green chemistry is a powerful tool for the more
affordable and ecologically benign synthesis of organic molecules, such as quinoline derivatives
via an efficient base-mediated/metal-free approach.

Objective:
The primary objective of the work presented in this article was to prepare N-(2-(tertbutylamino)-
1-(2-chloro-5,7-dimethylquinolin-3-yl)-2-oxoethyl)-3-methoxy-N-phenylbenzamide
derivatives via single-step Multicomponent Reaction. Characterized it, docking it, and their anticancer
activities against different cell lines are evaluated.

Methods:
In a sealed glass vial, one of the starting materials 2-chloro-5-7-dimethylquinoline-3-
carbaldehyde 1 was synthesized by the Vilsmeier-hack reaction. Substituted N-(2-(tertbutylamino)-
1-(2-chloro-5,7-dimethylquinolin-3-yl)-2-oxoethyl)-3-methoxy-N-phenylbenzamide
were obtained by the Ugi-Multi Component reaction of 2-chloro-5-7-dimethylquinoline-3-
carbaldehyde 1, aniline 2a, 3-methoxybenzoic acid 3 and t-butyl isocyanides 4 were dissolved
sequence vise in 2,2,2-trifluoroethanol (TFE) reaction solvent. This method is an efficient basemediated/
metal-free approach to synthesizing quinoline derivatives.

Results:
We have successfully synthesized the quinoline derivatives via Ugi-multicomponent reaction
via an efficient base-mediated/metal-free approach. The structures of the compounds were
confirmed through various spectroscopic techniques. Characterized it, docking it, and their anticancer
activities against different cell lines are evaluated.

Conclusion:
The reported protocol is advantageous over conventional methods of quinoline derivatives
via an efficient base-mediated/metal-free approach. Quinoline derivatives were tested for
anticancer efficacy against 9 distinct subpanels of NCI-60 cell lines among which 5d and 5j have
been found to be more potent against different cell lines. In order to get mechanistic insights into
this antitumor activity, molecular docking analysis against critical target CDK2 was performed to
aid in understanding the molecular basis of anticancer activity. The results of binding affinity
were in harmony with the anticancer activity providing valuable insights into the various thermodynamic
interactions governing the binding affinity. By using the potential of quinoline derivatives
via an efficient base-mediated/metal-free approach, more effective and accurate cancer
treatments can be designed in the future.
THE IMPLEMENTATION OF LEARNING TASKS IN THE WHEN ENGLISH RINGS A BELL TEXTBOOK FOR THE SEVENTH GRADE STUDENTS OF MTS NEGERI WONOSARI
Authors: Riyadi Agus , Sugirin Sugirin 
Published: September 2024

Abstract (Title: The Implementation of Learning Tasks in The When English Rings a Bell Textbook for The Seventh Grade Students of MTs Negeri Wonosari). This research aims to describe the implementation of learning tasks in the When English Rings a Bell textbook. This research was a descriptive qualitative research employing a descriptive and qualitative method of analysis. The subjects were an English teacher and 55 students of VII A and VII F of MTs. Negeri Wonosari in the academic year of 2014/2015. The objects of the research were the learning tasks in the When English Rings a Bell textbook (Chapters VIII and IX). The data were collected through observations, questionnaire, interviews, and document analysis. The data were analyzed using descriptive analysis technique applying the Miles and Huberman Model. The results of the research show that the goal of tasks in Chapters VIII and IX is that the students can develop their vocabulary mastery, and make a simple description of people, animals, and things around them. The materials presented were appropriate since the materials were interesting and close to the real world. The activities applied by the teacher were communication strategies, dialogues and role plays, discussions and decisions making, questions and answers, and exercises. The students participated actively in doing the tasks. The teacher performed his roles as a facilitator, manager, controller, organizer, assessor, prompter, participant, resource, tutor, and observer well. The settings were desks line in rows, horseshoe shape, parallel chair setting, and group to group setting. Keywords: implementation, learning tasks, facilitator, manager, controller.
EFEKTIVITAS MEDIA PERMAINAN SIMULASI DAN MEDIA GAMBAR PERISTIWA TERHADAP PRESTASI BELAJAR MATERI TEKS DISKUSI
Authors: Hidayatullah M. Jihad , Haryadi Haryadi 
Published: September 2024

Abstract(Title: The Effectiveness of Simulation Game Media and Event Pictures Media in Improving Learning Achievement in Discussion Text). This study aims to determine the issues concerning whether there is any significant difference among the stu­dents achievement in discussion text of bahasa Indonesia tested using simulation game media, event picture media, and other conventional media and whether there are any significant differences among the effectiveness of simulation game media, event picture media, and other conventional media in improving the achievement in discussion text of bahasa Indonesia for junior high school students in West Lombok. The data were collected through a multiple choice test abd analyzed by using ANOVA and Scheffe test using SPSS. The results of these study are: First, there are significant differences among the students achievement in discussion text of bahasa Indonesia tested using simulation game media, event picture media, and other conventional media, with F = 23,717 and p 0,05. Second, there are any significant differences among the effectiveness of simulation game media, event picture media, and other conventional media in improving the achievement in discussion text of bahasa Indonesia for junior high school students with conclusion; (1) the use of simulation game media is more effective than the use conventional media, with with a mean difference 15,166 and sig 0,05; (2) the use of event picture media is more effective than the use conventional media, with a mean difference 22,386 and sig 0,05; (3) the use of simulation game media is less effective than the use of event picture media, with a mean difference -7.220 and sig 0,05.Keywords: simulation game media, event pictures media, discussion text.
PERMASALAHAN SOSIAL DALAM NOVEL DI BATAS PELANGI KARYA ACHI TM
Authors: Silfia Mega , R. Syahrul , Afnita Afnita 
Published: September 2024

Abstract (Title: Social Problems in the Novel “Di Batas Pelangi” By Achi TM). This study aims to describe the social problems of family disorganization and violations of community norms in the novel In Batas Pelangi by Achi TM. The source of research data is linguistic exposure that contains problems of family disorganization and norm violations. Data collection by reading repeated readings and recording. Data were analyzed using a sociological approach to literature. The results of the study are as follows. First, the family disorganization experienced by the Wijaya family in the form of lack of communication between family members. This matter has caused ignorance and lack of attention of Mr. Wijaya and his wife towards their children. Secondly, due to the lack of concern and attention of Mr. Wijaya and his wife on the lifestyle of their seven children, their children finally did things that violated community norms, namely drug use, theft, and abuse.Keywords: disorganization, family, norms, norm violations
SAJAK-SAJAK RENDRA UNTUK PEMBELAJARAN EKOLOGIS DI ERA GLOBAL
Authors: Liliani Else , Budiyanto Dwi 
Published: September 2024

Abstract(Title: Rendra’s Poems for Ecological Learning in the Global Era). This study aims to describe environmental functions, ecological paradigms, and ecological learning compe­tencies that can be developed from Rendra's book Empat Kumpulan Sajak. The study was conducted in a qualitative descriptive manner. The source of the research data is the WS Rendra poems in the book Empat Kumpulan Sajak published by Pustaka Jaya (print in 2016). Data is taken purposively, in the form of poems containing ecological content. Data is recorded and listened to, then analyzed through ecocritical reading. The results of the study are as follows. First, the environment in Rendra's poems serves as a means to achieve aesthetic in poetry, to convey messages and convey environmental issues. Second, in a society that respects nature, the environment is a symbol of immortality and a source of peace, but in a society that begins to ignore nature, the environment changes function into an object that is only explored by its wealth and final disposal. Third, competencies that can be developed in literary learning through Rendra's poems related to environ­men­tal issues include cognitive, affective, practical, and spiritual competencies.Keywords: poetry, environmental issues, ecological learning, literary learning
NILAI-NILAI SOSIAL YANG TEREFLEKSIKAN MELALUI TOKOH-TOKOH PEREMPUAN DALAM DRAMA TRIFLES KARYA SUSAN GLASPELL: TINJAUAN SOSIOLOGI SASTRA
Authors: Anggraeni Niken , Kurnia Nandy Intan 
Published: September 2024

(Title: Social Values that are Reflected Through the Female Characters of “Trifles” by Susan Glaspell: Sociology of Literature Study). This study aims to find and explain the social values in Trifles as reflected through the female characters in it, through the description of the social situation they face and also to analyze how the social situation influences all decisions and actions taken by those female characters. The results of this study are (1) female characters in Trifles have to face the society that tend to be prejudiced and underestimate the role of women, (2) They do not pay attention to their surroundings, and (3) they use certain appropriateness values to accept or reject others. The situation described above gives an influence on all decisions and actions taken by them, i.e. (1) they decide to take unlawful actions by removing evidence of murder, (2) withdrawing from the community, (3) doing vile deed that is committing murder.Keywords: sociology of literature, social values, play.
lenguaje como gramática universal. El trazado de Foucault desde el momento de Sócrates, de Descartes hasta la desaparición del Hombre
Authors: Sánchez Cecilia 
Published: September 2024

El artículo aborda la concepción representativa de la gramática universal asociada al “momento cartesiano” de un orden sintáctico. Bajo la noción representacional del lenguaje, Foucault intenta dar cuenta del modo en que el sujeto moderno cree en la ficción de un acceso directo a la verdad, cuya genealogía proviene del conócete a ti mismo socrático. En esta genealogía, el trazado filosófico entre sujeto, verdad y lenguaje comienza con Sócrates, se detiene en Descartes, hasta llegar al lenguaje de la dispersión, según define al momento en que la lingüística y el psicoanálisis comienzan a deshacerse del hombre y de su gramática universal.
Experiência da Morte e do Morrer
Authors: De Paula Silva Eliana Aparecida , Oliveira Isabela Alline , Cândido Viviane Cristina 
Published: September 2024

Comumente as reflexões acerca da morte estão associadas a um antagonismo entre a vida e a morte e à compreensão isolada de diferentes áreas. Este artigo pretende pensar sobre o fenômeno social da morte a partir da Filosofia da Saúde. Para refletir sobre os aspectos sociológicos da morte, fizemos referência à obra A solidão dos moribundos, seguido de Envelhecer e Morrer, de Norbert Elias, que evidencia a institucionalização da morte e suas consequências para sua percepção como parte da vida.. Para subsidiar a reflexão filosófica, nos baseamos na obra Ecce homo do filósofo Friedrich Nietzsche, em que faz uma releitura sobre si mesmo, de como conviveu com a sua doença e tomou para si a sua cura, nos permitindo pensar na saúde, na doença e na morte como parte da vida. Considerando que o domínio da investigação do tema da morte e do morrer é vasto e multidisciplinar, a Sociologia e a Filosofia contribuem, cada qual com a sua especificidade para compreendermos esse processo e podem abrir um caminho dentro do âmbito da saúde,a partir de uma Filosofia da Saúde que, ao pensar as ciências da saúde e as práticas de seus profissionais, pressuponha a transdisciplinaridade.
Preparasi dan Karakterisasi Nanokolagen dari Tulang dan Kulit Belut Sawah (Monopterus albus) yang Berpotensi sebagai Bahan Baku Kosmetik
Authors: Puspitasari Dian 
Published: September 2024

Pengembangan bahan baku kosmetik berbasis nanopartikel semakin banyak dikembangkan dengan alasan karena partikel dengan ukuran nano akan lebih mudah untuk diserap dan terdifusi dalam kulit daripada partikel yang memiliki ukuran lebih besar. Hal ini juga lah yang mendasari dikembangkannya nano kolagen dari tulang dan kulit belut sawah yang berpotensi sebagai bahan baku kosmetik. Untuk membuktikan keberhasilan preparasi nano kolagen dari tulang dan kulit belut sawah tersebut maka pada penelitian ini dilakukan karakterisasi nanokolagen yang dihasilkan. Pada Penelitian ini kolagen diisolasi dengan Metode asam basa dilanjutkan dengan pengecilan ukuran partikel secara top down selanjutnya nanokolagen yang diperoleh dikarakterisasi meliputi kadar air, kadar lemak, kadar protein, ukuran partiel, zeta potensial dan analisis gugus fungsi dengan FTIR. Dari penelitian ini diperoleh Nanokolagen dari kulit dan tulang belut sawah dengan rendemen 2,28% yang memiliki karakteristik sebagai berikut kadar air 7,35 ± 0,38 %, kadar lemak 13,22 ± 0,41 %, kadar protein 24,89 ± 0,27 %, ukuran partikel 591,6 ± 77,2 nm, zeta potensial 0.2 mV dan hasil analisa FTIR menunjukkan puncak serapan khas kolagen yaitu Amida A, Amida B, Amida I, Amida II dan III.
Развитие морфологической науки в КБР (на базе КБГУ и КБГАУ)
Authors: Пилов А.Х. 
Published: September 2024

Статья посвящена становлению и развитию в Кабардино-Балкарской Республике среднего и высшего медицинского образования. Автор на примерах и достижениях показывает, что преподавание морфологических дисциплин ведется в полном соответствии с современными требованиями. Подчеркивает, что в республике проводяся глубокие научные исследования по актуальным проблемам анатомии, гистологии, практического здравоохранения и ветеринарной медицины
REFLECTION OF THE VALUES OF MODERN CHINESE SOCIETY IN THE PRC MEDIA
Authors: На Ли. 
Published: September 2024

Данная работа посвящена исследованию преобладающих на современном этапе ценностей китайского общества и достоверности отражения этих ценностей в средствах массовой информации Китая, их трансформации в историческом контексте, а также анализу внешних факторов, влияющих на формирование медиакоммуникации страны. В работе также исследуется специфика ценностных ориентиров, целенаправленно продвигаемых с помощью средств массовой информации отдельными государственными структурами.
Preliminary evaluation of ionized magnesium levels in dogs on long-term esomeprazole administration
Authors: Lee Jeongmin , Lee Seungkeun , Song Kunho , Evans Samantha , Her Jiwoong 
Published: September 2024

Abstract

OBJECTIVE
To investigate the level of whole-blood ionized magnesium (iMg) in dogs with long-term use of proton pump inhibitors (PPIs).

METHODS
The study included 10 client-owned dogs with esomeprazole administration over 6 months and 62 healthy dogs to determine de novo reference interval (RI) of iMg. Dogs that received esomeprazole for 6 months or longer were retrospectively reviewed to determine the incidence of hypo- or hypermagnesemia based on the de novo RI. Additionally, the iMg levels from the study group were compared with those of 20 age-, sex-, and body weight–matched controls from the 62 dogs.

RESULTS
The median (range) duration of esomeprazole usage was 26 months (6 to 94). The de novo RI for iMg was determined as 0.73 (90% CI, 0.58 to 0.87) to 1.43 mg/dL (90% CI, 1.33 to 1.46). Based on the RI, none of the dogs with long-term esomeprazole developed hypo- or hypermagnesemia. The iMg from the matched control group was 1.17 mg/dL (90% CI, 0.83 to 1.46). The lowest iMg after 6 months of esomeprazole administration (90% CI, 0.96 mg/dL, 0.87 to 1.41) was significantly lower than the control group (P = .031). The iMg measured at the end of long-term esomeprazole treatment was 1.03 mg/dL (90% CI, 0.87 to 1.41) and not significantly different from the control group (P = .179).

CONCLUSIONS
Ionized hypomagnesemia was not observed after long-term use of esomeprazole in the small number of dogs included in this study. Robust RI needs to be determined in future studies to investigate the incidence of hypomagnesemia in dogs with long-term use of PPIs.

CLINICAL RELEVANCE
Future studies in a larger number of dogs are warranted to confirm the findings from the present study and to determine whether the long-term use of esomeprazole in dogs is at risk of developing ionized hypomagnesemia.
In vitro mechanism of luteolin suppresses enhanced endothelial permeability
Authors: Shuit S.C , Wong T.Y , Omar Fauzee M.S , Zuraini A , Somchit M.N 
Published: September 2024

Abstract
Luteolin, a flavonoid, has been reported to inhibit the enhanced endothelial permeability in vitro. The purpose of this study was to determine the mechanism of luteolin affected the in vitro suppression of elevated endothelial permeability involves protein kinase C activity and intracellular calcium concentration. The inducer bradykinin was tested using the in vitro vascular permeability assay in endothelial cells obtained from human umbilical vein endothelial cells (HUVECs). Protein kinase C assay test and the intracellular calcium concentration were also determined. Results revealed luteolin (5, 10, and 25 μM) significantly suppressed increased endothelial permeability (P < 0.001). The increased activity of protein kinase C was significantly suppressed by luteolin at the dose of 5 μM (P < 0.05), 10 μM (P < 0.01), and 25 μM (P < 0.01). The increased concentration of intracellular calcium was significantly suppressed by luteolin at the dose of 10 μM (P < 0.01) and 25 μM (P < 0.001). Collectively, these results showed luteolin suppressed the activity of protein kinase C and suppressed the increased concentration of intracellular calcium when HUVECs were induced by bradykinin, leading to the suppression of increased endothelial permeability as the nitric oxide-cyclic guanosine monophosphate (NO-cGMP ) pathway was being inactivated. This may explain the pharmacologic properties of luteolin, which is anti-inflammatory, antioxidant, and neuroprotective. These results also revealed the potential use of luteolin in treating many other diseases involve endothelial permeability.