bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insights into management and physiological determinants of lowest pod height in soybean
Authors: Goufo Piebiep , Kluver Robert W. , Cerrudo Aníbal , Naeve Seth L. 
Published: October 2024

AbstractHarvest losses caused by the low height of the lowest pods (LPH) are a significant issue in soybean cultivation. Minimizing these losses requires identifying management, physiological, and agronomic factors that interactively modulate LPH. Four studies were conducted to examine the relationships among soybean LPH, node and internode features, and light quality under different management practices. These practices included population density (19, 31, and 43 plants m−2) and row width (equidistant, 25, 51, and 76 cm), relative maturity (maturity group [MG] 0.8, MG 2.1, and MG 2.8), mulch color (gray bare soil, red mulch, and white mulch), and timing of stand reduction (V1, R3, R4, and R5 growth stages). An increase in population density from 19 to 43 plants m−2 led to an average increase in LPH of 28%, from 11.9 to 15.3 cm. LPH was not influenced by row width. Later maturing cultivars demonstrated the highest potential for enhancing LPH, with late AG2802 having a higher LPH (18.8 cm) than early AG0803 (12.4 cm). Data indicated that the elongation of internodes 10, 11, and 12, along with changes in the red to far‐red light ratio beneath the canopy, plays a pivotal role in determining the location of the lowest pods. Moreover, LPH is established around the R3 growth stage. Nevertheless, further investigations are warranted to gain a better understanding of how these parameters, individually and collectively, influence LPH in soybean.
Roles of noncoding RNA in allergic rhinitis
Authors: Zhao Xiangkun , Yang Yuteng , Wang Yaqi , Chen Xi , Yao Yisong , Yuan Ting , Li Jiaxuan , Li Yumei , Song Xicheng 
Published: October 2024

AbstractBackgroundAllergic rhinitis (AR) is one of the most common respiratory noninfectious diseases and chronic inflammatory diseases, the incidence of which has been increasing in recent years. The main pathological characteristics of AR are repeated inflammation, airway hyperreactivity, mucus hypersecretion, and reversible airway obstruction due to inflammatory cell response. AR occurrence is associated with various factors, including those of genetic and environmental origins. Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot be converted into polypeptides. The three main categories of ncRNAs include microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs). NcRNAs play a crucial role in controlling gene expression and contribute to the development of numerous human diseases.MethodsArticles are selected based on Pubmed's literature review and the author's personal knowledge. The largest and highest quality studies were included. The search selection is not standardized. Several recent studies have indicated the relationship of ncRNAs with the development of respiratory allergic diseases. NcRNAs, including miRNAs, lncRNAs, and circRNAs, are important gene expression regulatory factors. We review the expression and function of ncRNAs in AR, their role as disease biomarkers, and their prospective applicability in future research and clinically. We also discuss interactions between ncRNAs and their influence on AR comprehensively, these interactions are essential for determining the underlying pathological mechanisms further and discovering new drug therapeutic targets.ResultsNcRNAs can be used as biomarkers for early AR diagnosis, disease surveillance and prognosis assessment. Various categories of ncRNAs play distinct yet interconnected roles and actively contribute to intricate gene regulatory networks. They are also therapeutic targets and biomarkers in other allergic diseases.ConclusionThis article demonstrates ncRNAs have a wide range of applications in AR treatment. The database covers three key areas: miRNAs, lncRNAs, and circRNAs. Additionally, potential avenues for future research to facilitate the practical application of ncRNAs as therapeutic targets and biomarkers will be explore. With further research and technological development, ncRNAs may provide additional innovative, effective solutions for AR treatment.
Do images help? The impact of proenvironment photographs and graphs in environmental disclosures on investor perceptions and willingness to invest
Authors: Yang Xiaolan , Meng Wenting , Chen Shu 
Published: October 2024

AbstractThis study investigates the effects of proenvironment photographs and graphs in environmental disclosures on potential investors' perceptions and willingness to invest, considering the moderating role of a company's environmental performance. An online experiment was conducted with experienced investors, where participants evaluated a hypothetical company with varying environmental performance outcomes (negative or positive) presented in different formats (text only, text with photographs, or text with graphs). The results indicate that proenvironment images enhance perceived environmental responsibility for companies with negative environmental performance, whereas processing fluency is improved when the image type aligns with environmental performance. Moreover, perceived environmental responsibility mediates the impact of images on the willingness to invest in negative performance contexts. In contrast, processing fluency mediates this effect for graphs in positive performance contexts. These findings offer guidance for company managers in effectively presenting environmental data and highlight the potential risks for policy‐makers regarding the misuse of images.
Bioactivity‐Based Analysis and Chemical Characterization of Hypoglycemic Components from Helicteres angustifolia L.
Authors: Tian Xiaoli , Zhao Yu , Zhang Ayu , Zhang Dongmei , Ren Jiayi , Bai Yidan , Yang Xi , Jantrawut Pensak , Cheng Delin , Zhang Jie 
Published: October 2024

AbstractHelicteres angustifolia L. (H. angustifolia), a well‐known traditional Chinese medicine, has been demonstrated to have hypoglycemic activity. We found that the EtOAc extract of H. angustifolia (HAEF) showed stronger α‐glucosidase inhibitory activity than that of positive control. Furthermore, the hypoglycemic activity of HAEF was evaluated in streptozotocin (STZ)‐induced type 2 diabetes mellitus (T2DM) rats. The results demonstrated that HAEF reduced the drinking quantity, feeding quantity, and controlled weight loss in diabetic rats. Besides, the fasting blood glucose (FBG), viscera index, and the area under time‐blood glucose curve (AUC) were significantly decreased, and the oral glucose tolerance was also improved after 5 weeks. Then, the high‐performance liquid chromatography with quadrupole time of flight tandem mass spectrometry (HPLC−Q‐TOF‐MS/MS) method was performed for qualitative analysis of the chemical constituents in HAEF. Twenty‐one compounds were identified from in HAEF. Four compounds were further isolated from HAEF and subjected to α‐glucosidase inhibition experiments. At the end, molecular docking was empolyed simulate the interaction of three compounds with α‐glucosidase. This is the first report on major hypoglycaemic components has been identified in the roots of H. angustifolia. These findings provide a material basis for the use of H. angustifolia in the treatment of diabetes.
Design, Synthesis, and Biological Evaluation of New Improved Ferrostatin‐1 Derived Ferroptosis Inhibitors
Authors: Zhang Nai‐Yu , Liu Jun‐Yu , Zheng Hui , Wang Kai‐Ming , Zhang Juan , Meng Ning , Jiang Cheng‐Shi 
Published: October 2024

AbstractFerrostatin‐1 (Fer‐1), a first potent ferroptosis inhibitor, faces limitations in clinical use due to its low potency and metabolic instability. This study introduces a series of novel Ferrostatin‐1 analogs designed to enhance plasm stability. Our design strategy focused on the modification of the 3‐NH2 of Fer‐1 with benzenesulfonyl groups, resulting in analogs 9–25. Biological evaluation revealed that compound 18, with an EC50 value of 0.57 μM, outperformed Fer‐1 in inhibiting ferroptosis. It reduced intracellular ferrous ion accumulation, lipid peroxidation, and restored glutathione (GSH) and glutathione peroxidase 4 (GPX4) levels effectively. Moreover, compound 18 exhibited favorable solubility and remarkable metabolic stability in rat plasma. These results position compound 18 as a promising candidate for developing therapeutics against ferroptosis‐related diseases.
Innovative On‐Resin and in Solution Peptidomimetics Synthesis via Metal‐Free Photocatalytic Approach
Authors: Gandini Tommaso , Vaghi Francesco , Laface Zoe , Macetti Giovanni , Bossi Alberto , Penconi Marta , Luisa Gelmi Maria , Bucci Raffaella 
Published: October 2024

AbstractNowadays, peptidomimetics are widely studied, being useful tools in drug discovery and medicinal chemistry. The coupling between a carboxylic acid with an amine to form a peptide bond is the most common reaction to obtain peptides/peptidomimetics. In this work, we have investigated an innovative metal‐free photoredox‐catalyzed carbamoylation to form peptidomimetics thanks to the reaction between dihydropyridines functionalized with amino acids (or peptide sequences) and differently functionalized imines. As the organic photocatalyst, we used 4CzIPN, a donor‐acceptor cyanoarene vastly used in photoredox catalysis. By easily modulating the amino acid (or peptide sequence), which is directly attached to the dihydropyridine, we proposed this key‐reaction as new valuable method to obtain peptidomimetics, in situ building the not‐natural portion of the sequence. Moreover, we successfully employed this methodology in solid phase peptide synthesis, both inserting the new photoredox‐generated amino acid at the end or in the middle of the sequence. Peptides with different lengths and secondary structures were prepared, proving the success of this approach, even in sterically hindered environment. Herein, to the best of our knowledge, we describe the first photocatalytic protocol which allows the building of the peptide backbone, with the possibility of simultaneously inserting a non‐coded amino acid in the sequence.
Image enhancement for dichromatic vision by geometric approach in RGB color space
Authors: Azetsu Tadahiro , Fujita Ayaka , Suetake Noriaki 
Published: October 2024

AbstractThe goal of this study is to process digital images to facilitate color discrimination in dichromatic vision without changing their appearances in trichromatic vision as much as possible. Therefore, we propose a simple and effective image enhancement method using the geometric properties of the RGB color space. Concretely, a novel image representation that clarifies the relationship between dichromatic and trichromatic visions in the RGB color space, and an image enhancement method based on this representation are presented. The effectiveness of the proposed method is verified by experiments using several digital images.
Ionomer and Membrane Designs for Low‐temperature CO2 and CO Electrolysis
Authors: Deng Huiying , Chen Zhuo , Wang Yuhang 
Published: October 2024

AbstractLow‐temperature electroreduction of CO2 and CO (CO(2)RR) into valuable chemicals and fuels offers a promising pathway to reduce greenhouse gas emissions and achieve carbon neutrality. Today′s low‐temperature CO(2)RR technology relies on the use of ionomers, polymers with ionized groups, primarily as catalyst layer (CL) additives. In the meantime, ionomers can assemble into ion‐exchange membranes (IEMs), serving as important components of electrolyzers. According to the ion‐exchange functions, ionomer additives are classified as cation‐exchange ionomers (CEIs) and anion‐exchange ionomers (AEIs); similarly, IEMs are divided into cation‐exchange membranes (CEMs) and anion‐exchange membranes (AEMs), as well as the multilayer polymer electrolytes (MPEs). Recent studies show that ionomer additives can regulate the catalytic microenvironment and thereby enhance performance towards desired products. This Review discusses the roles of ionomer additives and IEMs in CO2 and CO reduction reactions, highlighting the latest mechanistic insights and performance advances. It outlines challenges in designing ionomer additives and IEMs to improve product selectivity, energy efficiency (EE), and operational lifetime of CO(2)RR electrolyzers, while also providing perspectives on future research directions. The aim is to connect the current status of ionomer and membrane development with performance metrics analysis, offering insights for the advancement of commercially relevant low‐temperature CO(2)RR electrolyzers.
Long‐term efficacy (at and beyond 1 year) of gastric peroral endoscopic myotomy for refractory gastroparesis: A systematic review and meta‐analysis
Authors: Mandarino Francesco Vito , Barchi Alberto , Salmeri Noemi , Azzolini Francesco , Fasulo Ernesto , Dell'Anna Giuseppe , Vespa Edoardo , Sinagra Emanuele , Jacques Jeremie , Danese Silvio 
Published: October 2024

AbstractIntroductionAlthough gastric peroral endoscopic myotomy (G‐POEM) has shown substantial efficacy in patients with medically refractory gastroparesis (GP), comprehensive long‐term data on its effectiveness are lacking.MethodsWe conducted a systematic review and meta‐analysis including observational studies assessing long‐term efficacy after G‐POEM in patients with refractory GP. Our primary outcome was the pooled rate of clinical success 1‐year after G‐POEM. Secondary outcomes included clinical success at 2 and 3 years and the rate of adverse events according to the American Society for Gastrointestinal Endoscopy classification.ResultsThirteen studies, involving 952 patients with refractory GP undergoing G‐POEM, were eligible. The pooled 1 year‐clinical success was 0.72 (95% confidence interval [CI]: 0.56, 0.85, I2 = 94.9%). The clinical success was 0.67 (95% CI: 0.47, 0.97, I2 = 95.8%) when considering only studies defining success as 1 point decrease in Gastroparesis Cardinal Symptoms Index score and at least 25% decrease in two subscales. For patients who had 1‐year success, the pooled clinical success at 2 and 3 years were 0.71 (95% CI: 0.45, 0.92, I2 = 94.9%) and 0.58 (95% CI: 0.19, 0.92, I2 = 97.1%), respectively. The pooled rate of adverse events was 0.08 (95% CI: 0.06, 0.10, I2 = 0%).ConclusionG‐POEM is associated with successful outcomes in about 70% of treated cases after 1 year, with durable long‐term effects lasting up to 3 years. In the future, new uniform outcome definitions and strict patient selection criteria are warranted to delineate G‐POEM outcomes more accurately.
Principles of designing electrocatalysts to boost C–N coupling reactions for urea synthesis
Authors: Li Jingwei , Li Shengkai , Zhang Yaohao , Liu Zhao‐Qing 
Published: October 2024

AbstractThe electrocatalytic C–N coupling reaction can achieve green and sustainable urea synthesis as well as CO2 conversion and nitrogen fixation. However, the electrocatalytic C–N coupling reaction still faces challenges such as difficult adsorption and activation of reactive species, a large number of reactive intermediates, high reaction energy barriers, and inert reactive kinetics, resulting in the low urea yielding rate and Faradic efficiency. The development of efficient catalysts is key to improve the urea yielding rate and Faradic efficiency. This review covers the development history and basic principles of electrocatalytic C–N coupling for urea production, analyzes the nanostructure–catalytic activity relationship as well as the electronic structure–catalytic activity relationship, and discusses the main reaction mechanism of electrocatalytic C–N coupling for urea production. Based on these analyses, the concept of designing efficient C–N coupling catalysts is derived. Finally, the research status of electrocatalytic C–N coupling for urea synthesis is summarized, and the prospect for developing efficient electrocatalysts and C–N coupling mechanism are proposed.
Comparable Theta Phase Coding Dynamics Along the Transverse Axis of CA1
Authors: Bishnoi Aditi , Deshmukh Sachin S. 
Published: October 2024

ABSTRACTTopographical projection patterns from the entorhinal cortex to area CA1 of the hippocampus have led to a hypothesis that proximal CA1 (pCA1, closer to CA2) is spatially more selective than distal CA1 (dCA1, closer to the subiculum). While earlier studies have shown evidence supporting this hypothesis, we recently showed that this difference does not hold true under all experimental conditions. In a complex environment with distinct local texture cues on a circular track and global visual cues, pCA1 and dCA1 display comparable spatial selectivity. Correlated with the spatial selectivity differences, the earlier studies also showed differences in theta phase coding dynamics between pCA1 and dCA1 neurons. Here we show that there are no differences in theta phase coding dynamics between neurons in these two regions under the experimental conditions where pCA1 and dCA1 neurons are equally spatially selective. These findings challenge the established notion of dCA1 being inherently less spatially selective and theta modulated than pCA1 and suggest further experiments to understand theta‐mediated activation of the CA1 sub‐networks to represent space.
Foliar solution hydrophobicity influenced by plant species, product, and concentration
Authors: Bethea Frank G. , Liu Haibo , Bruce Terri , Bridges William , Lou Hong 
Published: October 2024

AbstractFoliar application of nutrients and pesticides is a popular practice for plant maintenance and weed control. Understanding how different products and adjuvants interact with the intended plant leaf surface will improve uptake and decrease losses. Various fertilizer, adjuvant, and pesticide solutions were tested to determine solution hydrophobicity on St. Augustinegrass, tall fescue, and white clover. A 1 µL droplet of each solution was placed on the adaxial leaf surface and imaged with a stereomicroscope to determine average solution contact angle. For all solutions groups, plant species had the most consistent effect, with white clover having the highest average contact angle followed by St. Augustinegrass and tall fescue, respectively. All product solutions significantly reduced the average contact angle compared to water. The urea solution resulted in the largest decrease for the fertilizer group at 7.6%. The largest decrease was found with the siloxane nonionic surfactant, which resulted in a decrease of 87.5% compared to water alone. Significant interactions were found between plant species and product solutions, indicating product solutions interact differently dependent upon the leaf surface characteristics. The results suggest that plant leaf surface, product solution and concentration, and their combination should be accounted for to increase wettability of a foliar application and improve product absorption.
Non‐clinical safety evaluation of Yongdamsagan‐tang water extract: A 13‐week subchronic oral toxicity study in Sprague Dawley rats
Authors: Jeon Woo‐Young , Seo Chang‐Seob , Ha Hyekyung , Shin Hyeun‐Kyoo , Cho Jae‐Woo , Lee Mee‐Young 
Published: October 2024

AbstractDespite the continued clinical application of traditional herbal medicines, scientific evidence such as toxicological safety profile of Yongdamsagan‐tang water extract (YSTW) has not yet been established. The purpose of this study was to investigate the potential toxicity profile of YSTW following a 13‐week repeated oral administration at various concentrations to Sprague Dawley rats. YSTW was administered orally to rats once daily at doses of 0, 1000, 2000, and 5000 mg/kg bw/day for 13 weeks. During the experimental period, there were no significant toxicological changes related to YSTW treatment. These results indicate that the administration of YSTW for 13 weeks in the rat resulted in no signs of toxicity at up to 5000 mg/kg bw/day, which was considered the no‐observed‐adverse‐effect level.
Biomimetic bilayer scaffold from Bombyx mori silk materials for small diameter vascular applications in tissue engineering
Authors: Gaviria Castrillon Ana M. , Wray Sandra , Rodríguez Aníbal , Fajardo Sahara Díaz , Machain Victoria A. , Parisi Julieta , Bosio Gabriela N. , Kaplan David L. , Restrepo‐Osorio Adriana , Bosio Valeria E. 
Published: October 2024

AbstractEnhancing the biocompatibility and mechanical stability of small diameter vascular scaffolds remain significant challenges. To address this challenge, small‐diameter tubular structures were electrospun from silk fibroin (SF) from silk textile industry discarded materials to generate bilayer scaffolds that mimic native blood vessels, but derived from a sustainable natural material resource. The inner layer was obtained by directly dissolving SF in formic acid, while the middle layer (SF‐M) was achieved through aqueous concentration of the protein. Structural and biological properties of each layer as well as the bilayer were evaluated. The inner layer exhibited nano‐scale fiber diameters and 57.9% crystallinity, and degradation rates comparable with the SF‐M layer. The middle layer displayed micrometer‐scale fibers diameters with an ultimate extension of about 274%. Both layers presented contact angles suitable for cell growth and cytocompatibility, while the bilayer material displayed an intermediate mechanical response and a reduced enzymatic degradation rate when compared to each individual layer. The bilayer material emulates many of the characteristics of native small‐diameter vessels, thereby suggesting further studies towards in vivo opportunities.
On the Constructor–Blocker game
Authors: Balogh József , Chen Ce , English Sean 
Published: October 2024

AbstractIn the Constructor–Blocker game, two players, Constructor and Blocker, alternately claim unclaimed edges of the complete graph . For given graphs and , Constructor can only claim edges that leave her graph ‐free, while Blocker has no restrictions. Constructor's goal is to build as many copies of as she can, while Blocker attempts to minimize the number of copies of in Constructor's graph. The game ends once there are no more edges that Constructor can claim. The score of the game is the number of copies of in Constructor's graph at the end of the game when both players play optimally and Constructor plays first. In this paper, we extend results of Patkós, Stojaković and Vizer on to many pairs of and : We determine when and , also when both and are odd cycles, using Szemerédi's Regularity Lemma. We also obtain bounds of when and .