bluuebunny/crossref_metadata_2025_split huggingface dataset:
Low Cost and Rapidly Processed Randomly Oriented Carbon/Carbon Composite Bipolar Plate for PEM Fuel Cell
Authors: Raunija T. S. K. , Gautam R. K. , Bhradwaj V. M. , Nandikesan N. , Shaneeth M. , Sharma S. C. , Verma A. 
Published: October 2016

AbstractThe objective of the present work is to develop carbon/carbon (C/C) composite bipolar plate at low cost with rapid processing time by a novel process. Carbon/carbon composite was developed using exfoliated carbon fiber reinforcement, isroaniso as primary matrix precursor, and resole type phenolic resin as secondary matrix precursor. Randomly oriented hybrid carbon fiber (T‐800 and P‐75) reinforced hybrid carbon matrix composite was fabricated. The slicing and channel forming were carried out using simple and conventional machines. The competency of the material was investigated by characterizing and analyzing density, scanning electron miscroscopy (SEM), compressive strength, compressive modulus, flexural strength, tensile strength, impact strength, hardness, electrical conductivity, thermal conductivity, coefficient of thermal expansion, permeability, and corrosion current. The C/C composite bipolar plate with exfoliated carbon fibers offered bulk density 1.75 g cm−3, tensile strength 45 MPa, flexural strength 98 MPa, compressive strength 205 MPa, electrical conductivity 190 (through‐plane) and 595 S cm−1 (in‐plane), and thermal conductivity 24 (through‐plane) and 51 W m−1 K−1 (in‐plane). Further, single cell test was performed to evaluate the effectiveness of the C/C composite bipolar plate in the PEM fuel cell and the performance was compared with the commercial graphite bipolar plate at different operating temperatures.
Substituent impact of B, Si, or P main group elements on the photophysical properties of phenyleneethynylenes
Authors: Sanji Takanobu , Fuchigami Akemi , Tanaka Masato 
Published: October 2016

AbstractThe synthesis and photophysical properties of a series of phenyleneethynylenes containing a main group element moiety of B, Si, or P on the side chain as a simple model are reported. The HOMO‐LUMO energy levels are significantly altered due to a rise of the HOMO level (P) or a lowering of the LUMO level (B and PO) compared with the parent phenyleneethynylene, which is also supported by density functional theory calculations. In addition, the optical properties of boron‐ and phosphorus‐containing π systems are dramatically changed by the coordination of fluoride ion and oxidation, respectively.
Does the Timing of Food Stamp Distribution Matter? A Panel‐Data Analysis of Monthly Purchasing Patterns of US Households
Authors: Castellari Elena , Cotti Chad , Gordanier John , Ozturk Orgul 
Published: October 2016

AbstractIn this paper, we examine the relationship between the timing of food stamp receipt and purchasing patterns. We combine data on state distribution dates of food stamps with scanner data on a panel of households purchases tracked between 2004 and 2011. We find that purchases of a variety of goods are meaningfully higher on receipt days, consistent with previous work that suggests that recipients are very impatient. Additionally, and importantly, estimates indicate that when food stamp receipt days fall on weekends, total monthly purchases within the same households are affected. In particular, monthly purchases of beer are higher when food stamps are distributed on a weekend rather than in months where benefits are distributed on weekdays. For these households, total beer purchases are between 4 and 5% higher in those months. Among households ineligible for food stamps, no effect is identified. These results demonstrate that the ‘day‐of‐the‐week’ of SNAP treatment may have important impacts on household purchase habits. Copyright © 2016 John Wiley & Sons, Ltd.
External Validity of Contingent Valuation: Comparing Hypothetical and Actual Payments
Authors: Ryan Mandy , Mentzakis Emmanouil , Jareinpituk Suthi , Cairns John 
Published: October 2016

AbstractWhilst contingent valuation is increasingly used in economics to value benefits, questions remain concerning its external validity that is do hypothetical responses match actual responses? We present results from the first within sample field test. Whilst Hypothetical No is always an Actual No, Hypothetical Yes exceed Actual Yes responses. A constant rate of response reversals across bids/prices could suggest theoretically consistent option value responses. Certainty calibrations (verbal and numerical response scales) minimise hypothetical–actual discrepancies offering a useful solution. Helping respondents resolve uncertainty may reduce the discrepancy between hypothetical and actual payments and thus lead to more accurate policy recommendations. Copyright © 2016 John Wiley & Sons, Ltd.
Detection of L265P MYD‐88 mutation in a series of clonal B‐cell lymphocytosis of marginal zone origin (CBL‐MZ)
Authors: Kalpadakis Christina , Pangalis Gerassimos A. , Vassilakopoulos Theodoros P. , Roumelioti Maria , Sachanas Sotirios , Korkolopoulou Penelope , Koulieris Efstathios , Moschogiannis Maria , Yiakoumis Xanthi , Tsirkinidis Pantelis , Pontikoglou Charalampos , Rondoyianni Dimitra , Papadaki Helen A. , Panayiotidis Panayiotidis , Angelopoulou Maria K. 
Published: October 2016

AbstractClonal B‐cell lymphocytosis of marginal zone origin (CBL‐MZ) is a recently described entity characterized by the presence of clonal B cells in the blood and/or bone marrow (BM) with morphologic and immunophenotypic features consistent with marginal zone derivation in otherwise healthy individuals. CBL‐MZ is commonly associated with paraproteinemia, usually immunoglobulin M (IgM), raising diagnostic difficulties from Waldenstrom macroglobulinemia (WM). The aim of the present study was to determine the presence of MYD‐88 L265P mutation in a well‐characterized series of CBL‐MZ to identify cases that may in fact represent WM. Fifty‐three CBL‐MZ cases were retrospectively evaluated. MYD‐88 L265P mutation was determined by allele‐specific polymerase chain reaction in blood and/or BM mononuclear cells. Almost half of the CBL‐MZ cases (49%) were associated with paraproteinemia mainly of the IgM type (65%). MYD‐88 L265P mutation was identified in 10 cases (19%). These cases may truly represent WM, whereas 43 cases (81%) are still classified as CBL‐MZ. Mutated cases were all associated with paraproteinemia compared with 37% of the nonmutated ones (P < .0001). In addition, mutated cases displayed more frequently CD38 and CD25 positivity (P = .002 and P = .005, respectively). Moreover, cases without paraproteinemia presented more frequently with lymphocytosis, irrespective of the presence of the MYD‐88 mutation (P = .02). The present study demonstrates that MYD‐88 L265P mutation may represent the only sensitive marker for the differentiation of CBL‐MZ from probable WM. However, further studies are warranted to better define the biological significance of MYD‐88 L265P mutation and to clarify whether the presence of the mutation establishes WM diagnosis or that it can also be present in borderline cases associated with paraproteinemia.
Follicular dendritic cell sarcoma treated with a variety of chemotherapy
Authors: Sasaki Masaoki , Izumi Hiroaki , Yokoyama Takaaki , Kojima Motohiro , Hosono Ako 
Published: October 2016

AbstractFollicular dendritic cell sarcoma (FDCS) is a very rare malignant tumor derived from follicular dendritic cells. Radical resection is the standard therapy for patients with local disease, but an optimal chemotherapy regimen has not been determined for unresectable disease. We report our experience of an FDCS patient with multiorgan involvement. In the present case, disease was only located in the pancreas initially and radical resection was performed. Multiple metastasis developed after the treatment and several factors that indicated a poor prognosis were observed. The present case had a very poor prognostic disease but survived for a long time with a good performance status because of the multiple chemotherapy regimens, which follow therapeutic strategies for malignant lymphoma and soft tissue sarcoma. As far as we know, this is the first study reporting the indication of bendamustine for FDCS patients.
Enteroviral infection in patients treated with rituximab for non‐Hodgkin lymphoma: a case series and review of the literature
Authors: Grisariu S. , Vaxman I. , Gatt M. , Elias S. , Avni B. , Arad A. , Pasvolsky O. , Raanani P. , Paltiel O. 
Published: October 2016

AbstractIn recent years, anti‐CD20 antibodies have been increasingly used to treat lymphoproliferative and immune disorders. Chronic viral infections are infrequently reported in patients receiving these therapies. Enteroviral infection can cause life‐threatening meningoencephalitis and other systemic chronic syndromes in immune deficient patients. We describe the clinical courses and outcomes of 6 patients from 2 tertiary care institutions who developed chronic enteroviral infection with neurological manifestations, after combined chemoimmunotherapy with rituximab for B‐cell lymphoma. We review the literature that includes 10 sporadic reported cases of chronic enteroviral meningoencephalitis attributed to rituximab therapy. It is a rare disease, and its diagnosis is often elusive. We propose that low immunoglobulin G levels are the main risk factor for developing chronic enteroviral infection and emphasize the need for a high index of suspicion, early diagnosis, and intervention in this iatrogenic and potentially fatal complication.
Macro News and Commodity Returns
Authors: Caporale Guglielmo Maria , Spagnolo Fabio , Spagnolo Nicola 
Published: October 2016

AbstractThis paper adopts a vector autoregression‐generalized autoregressive conditional heteroscedasticity approach to model the dynamic linkages between both mean and variance of macro news and commodity returns (Gold, Corn, Wheat, Soybeans, Silver, Platinum, Palladium, Copper, Aluminium and Crude Oil) over the period 01/01/2001–26/09/2014. The chosen specification also controls for the effect of the exchange rate. The results can be summarized as follows. Mean spillovers running from news to commodity returns are positive with the exception of Gold and Silver. Volatility spillovers are bigger in size and affect most commodity returns. Both first‐moment and second‐moment linkages are stronger in the post‐September 2008 period. Overall, our findings confirm that commodities, despite not being financial assets, are sensitive to macro news (especially their volatility) and also suggest that the global financial crisis has strengthened such linkages. Copyright © 2016 John Wiley & Sons, Ltd.
Effective cancer targeting and imaging using macrophage membrane‐camouflaged upconversion nanoparticles
Authors: Rao Lang , He Zhaobo , Meng Qian‐Fang , Zhou Ziyao , Bu Lin‐Lin , Guo Shi‐Shang , Liu Wei , Zhao Xing‐Zhong 
Published: October 2016

AbstractUpconversion nanoparticles (UCNPs), with fascinating optical and chemical features, are a promising new generation of fluorescent probes. Although UCNPs have been widely used in diagnosis and therapy, there is an unmet need for a simple and effective surface engineering method that can produce cancer‐targeting UCNPs. Here, we show that by coating particles with macrophage membranes, it becomes possible to utilize the adhesion between macrophages and cancer cells for effective cancer targeting. Natural macrophage membranes along with their associated membrane proteins were reconstructed into vesicles and then coated onto synthetic UCNPs. The resulting macrophage membrane‐camouflaged particles (MM‐UCNPs) exhibited effective cancer targeting capability inherited from the source cells and were further used for enhanced in vivo cancer imaging. Finally, the blood biochemistry, hematology testing and histology analysis results suggested a good in vivo biocompatibility of MM‐UCNPs. The combination of synthetic nanoparticles with biomimetic cell membranes embodies a novel design strategy toward developing biocompatible nanoprobes for potential clinical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 521–530, 2017.
Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis
Authors: Rajan Thangavelu Soundara , Scionti Domenico , Diomede Francesca , Grassi Gianpaolo , Pollastro Federica , Piattelli Adriano , Cocco Lucio , Bramanti Placido , Mazzon Emanuela , Trubiani Oriana 
Published: October 2016

ABSTRACTResearch in recent years has extensively investigated the therapeutic efficacy of mesenchymal stromal cells in regenerative medicine for many neurodegenerative diseases at preclinical and clinical stages. However, the success rate of stem cell therapy remains less at translational phase. Lack of relevant animal models that potentially simulate the molecular etiology of human pathological symptoms might be a reason behind such poor clinical outcomes associated with stem cell therapy. Apparently, self‐renewal and differentiation ability of mesenchymal stem cells may help to study the early developmental signaling pathways connected with the diseases, such as Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), etc., at in vitro level. Cannabidiol, a non‐psychotrophic cannabinoid, has been demonstrated as a potent anti‐inflammatory and neuroprotective agent in neurological preclinical models. In the present study, we investigated the modulatory role of cannabidiol on genes associated with ALS using human gingiva‐derived mesenchymal stromal cells (hGMSCs) as an in vitro model system. Next generation transcriptomic sequencing analysis demonstrated considerable modifications in the expression of genes connected with ALS pathology, oxidative stress, mitochondrial dysfunction, and excitotoxicity in hGMSCs treated with cannabidiol. Our results suggest the efficacy of cannabidiol to delineate the unknown molecular pathways, which may underlie ALS pathology at an early stage using hGMSCs as a compelling in vitro system. J. Cell. Biochem. 118: 819–828, 2017. © 2016 Wiley Periodicals, Inc.
Gluconobacter oxydans (ATCC 621H) catalyzed oxidation of furfural for detoxification of furfural and bioproduction of furoic acid
Authors: Zhou Xuelian , Zhou Xin , Xu Yong , Chen Rachel R 
Published: October 2016

AbstractBACKGROUNDThe bacterial strain Gluconobacter oxydans (ATCC 621H) was investigated for its potential biodetoxification properties through conversion of furfural to 2‐furoic acid (FA). Furfural is a common byproduct of lignocellulose feedstock pretreament processing and it is a putative inhibitor of several important microbial pathways.RESULTSBoth furfural and furfuryl alcohol exhibit significant substrate inhibition to biooxidation. To overcome this inhibition, a fed‐batch bioprocess was developed to convert furfural and furfuryl alcohol to the low‐toxic FA product. The optimized fed‐batch bioprocess gave FA concentrations exceeding 40 g L−1 with a productivity of 0.167 g L−1 h−1 and a yield of nearly 100%. In order to improve productivity, the whole cell catalysis was carried out in a compressed oxygen supply‐sealed and stirred tank reactor (COS‐SSTR). Similar to the flask studies, 38.18 g L−1 FA was obtained in 24 h.CONCLUSIONGluconobacter oxydans was found to oxidize both furfural and furfuryl alcohol to a single product, FA, with a yield close to 100%. Unlike other microorganisms, this strain does not have a metabolic system to further degrade FA, demonstrating its potential to produce this useful product from renewable resources. © 2016 Society of Chemical Industry
Evaluation of reaction parameters and kinetic modelling for Novozym 435 catalysed synthesis of isoamyl butyrate
Authors: Bansode Sneha R , Hardikar Mukta A , Rathod Virendra K 
Published: October 2016

AbstractBACKGROUNDThe work describes the synthesis of isoamyl butyrate, a fruity banana flavour using immobilised lipase [EC 3.1.1.3] as a biocatalyst in a solvent‐free system, under mild optimised reaction conditions. Kinetic modelling with Ping Pong Bi Bi models, and thermodynamic parameters were evaluated at different temperatures.RESULTThe optimised parameters of temperature, mole ratio and enzyme loading attained 96% maximum conversion of ester in 10 h. Novozym 435 was successively recycled nine times with 33% loss of initial enzyme activity. The kinetic parameters were found as: maximum rate constant (Vmax) = 28.027 mmol min−1 g−1 (of catalyst), rate constant for acid (Ka) = 0.636 mol L−1, rate constant for alcohol (Kb) = 0.657 mol L−1, rate constant for alcohol inhibition (Kib) = 0.022 mol L−1 at optimum conditions by varying initial concentration of acid from 1.5 to 8.3 mol L−1 and concentration of alcohol from 2.12 to 7.9 mol L−1. The possibility of mass transfer resistance was investigated using an effectiveness factor which was determined as 1.CONCLUSIONFrom kinetic modelling, the esterification reaction was found to obey the Ping Pong Bi Bi mechanism with substrate inhibition. From thermodynamic evaluation the activation energy (Ea) for reaction, Gibbs free energy change (ΔG), and the enthalpy change (ΔH) was obtained as 16 kJ mol−1, 71 kJ mol−1 and 13 kJ mol−1, respectively. © 2016 Society of Chemical Industry
Porcine models for the study of small‐for‐size syndrome and portal inflow modulation: literature review and proposal for a standardized nomenclature
Authors: Mohkam Kayvan , Darnis Benjamin , Mabrut Jean‐Yves 
Published: October 2016

AbstractPorcine models of extended hepatectomy and liver transplantation (LT) of reduced graft have been widely used for studying the small‐for‐size (SFS) syndrome and the various modalities of portal inflow modulation (PIM). However, considerable heterogeneity exists among the studies and their results. The aim of this review was to assess the main advantages and drawbacks of the different porcine models of SFS LT and SFS hepatectomy, and propose a standardized anatomical nomenclature for the various models. The MEDLINE database was searched for articles reporting porcine models of reduced graft LT or hepatectomy of more than 65%. Nineteen articles on SFS LT matched our inclusion criteria, including 10 articles reporting a model of PIM. Twenty‐seven articles reporting a model of posthepatectomy SFS were identified, of which 16 reported a model of PIM. Subtotal hepatectomy (i.e. resection of all segments except segment 1) without inflow occlusion, left trisectionectomy with inflow occlusion, and LT of a right lateral section including the caudate lobe in a larger recipient appeared to be the most suitable porcine models for studying the SFS syndrome. All three models were appropriate for assessing the surgical and pharmaceutical PIM modalities, except for those involving the splenic flow.
Mesopancreas is a misnomer: time to correct the nomenclature
Authors: Sharma Dhananjaya , Isaji Shuji 
Published: October 2016

AbstractFocused pathological attention to tumor invasion of the retroperitoneal resection margin after pancreaticoduodenectomy for cancer of head of the pancreas led to the knowledge of strong tendency of cancer cells to infiltrate into the retropancreatic tissue and to spread along the peripancreatic neural plexuses as the cause of local recurrence. The term ‘mesopancreas’ was coined to describe perineural lymphatic layer located dorsally to the pancreas and it was suggested that its complete resection will minimize loco‐regional recurrence and improve outcome. This catchy title and concept attracted the attention of surgeons and “total meso‐pancreas excision” was introduced by ‘artery first’ or ‘posterior first’ surgical techniques to ensure ‘en‐bloc’ extended resection of retropancreatic lymphatics. However, mesopancreas is a misnomer and cannot be called a ‘true’ mesentery as it does not have a fascial envelope attaching the pancreas to the posterior wall of the abdomen and does not contain ‘all’ its blood vessels and ‘all’ its primary draining lymphatics and lymph nodes. Japan Pancreas Society's description of pancreatic head plexus II is anatomically consistent with ‘mesopancreas’ and it should be renamed as such. This nomenclature clearly illustrates its exact anatomical location and surgical relevance; and stands up to necessary rigorous scientific scrutiny.
Brain capillary transit time heterogeneity in healthy volunteers measured by dynamic contrast‐enhanced T1‐weighted perfusion MRI
Authors: Larsson Henrik B.W. , Vestergaard Mark B. , Lindberg Ulrich , Iversen Helle K. , Cramer Stig P. 
Published: October 2016

PurposeCapillary transit time heterogeneity, measured as CTH, may set the upper limit for extraction of substances in brain tissue, e.g., oxygen. The purpose of this study was to investigate the feasibility of dynamic contrast‐enhanced T1 weighted MRI (DCE‐MRI) at 3 Tesla (T), in estimating CTH based on a gamma‐variate model of the capillary transit time distribution. In addition, we wanted to investigate if a subtle increase of the blood–brain barrier permeability can be incorporated into the model, still allowing estimation of CTH.Materials and MethodsTwenty‐three healthy subjects were scanned at 3.0T MRI system applying DCE‐MRI and using a gamma‐variate model to estimate CTH as well as cerebral blood flow (CBF), cerebral blood volume (CBV), and permeability of the blood–brain barrier, measured as the influx constant Ki. For proof of principle we also investigated three patients with recent thromboembolic events and a patient with a high grade brain tumor.ResultsIn the healthy subjects, we found a narrow symmetric delta‐like capillary transit time distribution in basal ganglia gray matter with median CTH of 0.93 s and interquartile range of 1.33 s. The corresponding residue impulse response function was compatible with the adiabatic tissue homogeneity model. In two patients with complete occlusion of the internal carotid artery and in the patient with a brain tumor CTH was increased with values up to 6 s in the affected brain tissue, with an exponential like residue impulse response function.ConclusionOur results open the possibility of characterizing brain perfusion by the capillary transit time distribution using DCE‐MRI, theoretically a determinant of efficient blood to brain transport of important substances.Level of Evidence: 2J. MAGN. RESON. IMAGING 2017;45:1809–1820