bluuebunny/crossref_metadata_2025_split huggingface dataset:
One‐class SVM for biometric authentication by keystroke dynamics for remote evaluation
Authors: Eude Thierry , Chang Chuan 
Published: August 2017

AbstractRemote skills assessment in distance education needs individual identification in distinguishing between candidates and impostors. Keystroke dynamics is a behavioral biometrics which can be used to identify them. To expect lower error rate, behaviors should be as natural and consistent as possible. The unique identifier assigned to students at their registration seems appropriate but the classification method applied for this case of anomaly detection must be robust even with a lower signature number. In this paper, we first explain how we construct our own dataset. Three methods of selecting Gaussian kernel parameters for one‐class support vector machine are subsequently studied regarding the targeted application constraints. The results show that an indirect method as distance to farthest neighbor cannot be used because some signature features have multimodal and dispersed distributions. A method is then proposed based on the selection of the parameters via detecting the "tightness" of the decision boundaries and uses a greedy search. Its performances are compared to those of a grid search method using LibSVM. The results show that the proposed method is more robust when the signatures number decreases and better and more stable in detecting impostors.
Factors affecting fatigue severity in patients with obstructive sleep apnea
Authors: Kim Soo A , Koo Brian B , Kim Do Eui , Hwangbo Young , Yang Kwang Ik 
Published: August 2017

AbstractObjectivesA limited number of studies have investigated the relationships among fatigue, insomnia and obstructive sleep apnea (OSA). This study evaluated the factors affecting fatigue severity in patients with OSA.MethodsWe investigated 633 OSA patients who were diagnosed by polysomnography. All patients completed sleep questionnaires including self‐reported sleep duration, the Fatigue Severity Scale (FSS), the Korean version of Epworth Sleepiness Scale (K‐ESS), Insomnia Severity Index (ISI), Korean version of Pittsburgh Sleep Quality Index (K‐PSQI) and Beck Depression Inventory‐2 (BDI‐2).ResultsThe subjects had a mean age of 48.7 ± 10.5 years and 72.5% (n = 459) were men. The subjects were distributed as follows: 160 with mild, 168 with moderate and 305 with severe OSA. A multiple regression model found that age (β = −0.146, P = .005), K‐ESS (β = 0.689, P < .001), 8 ≤ ISI score < 15 (β = 3.801, P = .006), 15 ≤ ISI score (β = 4.565, P = .009), and K‐PSQI (β = 0.684, P = .002) were predictors of a higher FSS score. BDI‐2 (β = 0.007, P = .918), apnea‐hypopnea index (AHI) (β = −0.006, P = .895), arousal index (β = 0.034, P = .415), and nadir O2 saturation (β = −0.044, P = .655) were not associated with FSS score.ConclusionOur findings indicate that fatigue severity is more likely to be associated with younger age, sleepiness and insomnia, but less likely to be directly related to OSA severity.
Evaluation of a digital drainage system (Thopaz) in over 250 cases at a single site: A retrospective case‐control study
Authors: Arai Hiromasa , Tajiri Michihiko , Kameda Yohei , Shiino Kimihisa , Ando Kohei , Okudela Koji , Masuda Munetaka 
Published: August 2017

AbstractPurposeThe aim of this study was to evaluate the efficacy of the Thopaz system, a new drainage system in management of general thoracic surgery, based on a review of our clinical practice and a comparison of the utility of the Thopaz device compared with a standard drainage system.MethodsA review of 540 thoracic surgeries at our hospital was performed. These cases were divided into 275 treated with the Thopaz system from April 2014 to March 2015 and 265 treated with a standard system from April 2013 to March 2014. The characteristics of patients and outcomes after surgery were compared in these 2 groups.ResultsThe characteristics of the patients were similar in the 2 groups. Outcomes after surgery, including types of operation, period of chest tube placement, chest tube reinsertion rate and clamping test rate also did not differ significantly between the groups.ConclusionsThe non‐inferiority of the Thopaz system compared to a standard system was verified statistically. With advantages of providing objective data as a small portable system, in addition to the quietness of the unit and the ease of setup and operation, Thopaz system is likely to become mainstream in postoperative management in general thoracic surgery.
Environmental and spatial processes influencing phytoplankton biomass along a reservoirs‐river‐floodplain lakes gradient: A metacommunity approach
Authors: Bortolini Jascieli Carla , Pineda Alfonso , Rodrigues Luzia Cleide , Jati Susicley , Velho Luiz Felipe Machado 
Published: August 2017

Abstract

Evaluation of the relative influences of environmental and spatial processes in structuring aquatic metacommunities is an essential first step for understanding how these factors govern species distributions and affect spatial and temporal variability in community structure. Such variability has many causes and consequences at different scales. In the case of phytoplankton metacommunities, both species sorting and mass effect processes are likely to be important in structuring the patterns of biomass distribution on large spatial scales.

We investigated the influences of environmental and spatial components on the phytoplankton community on a large spatial scale, consisting of a reservoirs‐river‐floodplain lakes gradient in a Neotropical region. Using partial redundancy analysis, we partitioned the relative role of environmental (environmental filters) and spatial (asymmetric eigenvector maps) processes structuring phytoplankton biomass.

A clear difference of the limnological conditions was observed between the reservoirs and river–floodplain lakes system. High species richness and higher mean values of phytoplankton biomass were recorded in the floodplain lakes. Variation partitioning demonstrated the importance of both environmental and spatial process in phytoplankton biomass structuring. However, the relative importance of these processes may vary over time.

Our results suggest that from a metacommunity perspective, the phytoplankton biomass of upstream reservoirs and a downstream river–floodplain lakes system is determined by environmental conditions (species sorting process), mainly in the floodplain lakes; and by high dispersion rates favoured by the connectivity and unidirectional flow (mass effect process), mainly between the reservoirs and the river.
Marine‐terminating glaciers sustain high productivity in Greenland fjords
Authors: Meire Lorenz , Mortensen John , Meire Patrick , Juul‐Pedersen Thomas , Sejr Mikael K. , Rysgaard Søren , Nygaard Rasmus , Huybrechts Philippe , Meysman Filip J. R. 
Published: August 2017

AbstractAccelerated mass loss from the Greenland ice sheet leads to glacier retreat and an increasing input of glacial meltwater to the fjords and coastal waters around Greenland. These high latitude ecosystems are highly productive and sustain important fisheries, yet it remains uncertain how they will respond to future changes in the Arctic cryosphere. Here we show that marine‐terminating glaciers play a crucial role in sustaining high productivity of the fjord ecosystems. Hydrographic and biogeochemical data from two fjord systems adjacent to the Greenland ice sheet, suggest that marine ecosystem productivity is very differently regulated in fjords influenced by either land‐terminating or marine‐terminating glaciers. Rising subsurface meltwater plumes originating from marine‐terminating glaciers entrain large volumes of ambient deep water to the surface. The resulting upwelling of nutrient‐rich deep water sustains a high phytoplankton productivity throughout summer in the fjord with marine‐terminating glaciers. In contrast, the fjord with only land‐terminating glaciers lack this upwelling mechanism, and is characterized by lower productivity. Data on commercial halibut landings support that coastal regions influenced by large marine‐terminating glaciers have substantially higher marine productivity. These results suggest that a switch from marine‐terminating to land‐terminating glaciers can substantially alter the productivity in the coastal zone around Greenland with potentially large ecological and socio‐economic implications.
Relating factors to severe injury from outdoor falls in older people
Authors: Jung Hey Youn , Kim Sun Hyu , Lee Sang Cheal , Kim Sunpyo , Cho Gyu Chong , Kim Min Joung , Lee Ji Sook , Han Chul 
Published: August 2017

AimThe aim of the present study was to evaluate the clinical characteristics, including floor characteristics and factors, related to severe injury from outdoor falls in older adults.MethodsPatients were divided into two groups based on injury severity: the severe group and non‐severe group. The clinical and general characteristics were compared between the two groups, and factors associated with severe injury were investigated.ResultsApproximately 5% (364/7635) of older people involved in outdoor falls were classified into severe injury. The proportion of men and the rate of alcohol ingestion were higher in the severe group compared with that in the non‐severe group. Falling from stairs was a more frequent mechanism of fall in the severe group compared with that in the non‐severe group. Non‐slippery floor condition had a higher proportion in the severe group than that in the non‐severe group. Head and neck were the predominantly injured regions in both groups. Discharge was the most common result of emergency department treatment in the non‐severe group, whereas admission to intensive care unit was the main result in the severe group. Multivariate logistic analysis showed that male sex and falls from stairs rather than slipping down on the same level were associated with severe injury.ConclusionsFloor characteristics did not influence injury severity; however, the risk of severe injury from outdoor falls in older adults was high in men and those who fell from stairs. Geriatr Gerontol Int 2018; 18: 80–87.
Formation of bulk titanium boride (TiB) nano‐ceramic with Fe–Mo addition by electric‐field‐activated‐sintering
Authors: Du Jun , Ravi Chandran K. S. 
Published: August 2017

AbstractThe present work is focused on optimization of Fe–Mo content, which is essential for transient liquid phase formation and densification, during in‐situ reaction sintering of nanostructured titanium boride (TiB) in the bulk form. The principle objective is to develop a systematic understanding of how the Fe–Mo additions affect the densification, microstructure, and hardness of the TiB nano‐ceramic. Various TiB ceramic compositions, with varying Fe–Mo content and retaining a high‐volume fraction of TiB in the final microstructure, were made by the electric‐field‐activated‐sintering (EFAS) technique. An increase in Fe–Mo content is found to decrease the beginning point of densification temperature/time during the consolidation process through transient liquid phase formation. It is shown that at the optimum level of Fe–Mo, which is around 1.5 wt%, the density and hardness reach maximum levels with a least amount of spatial segregation of Fe within the ceramic. Interestingly, it has been found that Mo is uniformly incorporated within the orthorhombic lattice of the boride, while Fe is largely segregated to β‐Ti phase. At the optimal Fe–Mo content (1.5 wt%), a relative density of 99.7% and a Vickers hardness of 2050 ± 40 kg/mm2were achieved. From microstructural and X‐ray diffraction analyses, it is found that a high proportion of TiB (>99 vol%), with a least amount of metallic ductile phase, is formed in this composition.
Ripple mapping: Initial multicenter experience of an intuitive approach to overcoming the limitations of 3D activation mapping
Authors: Luther Vishal , Cortez‐Dias Nuno , Carpinteiro Luís , de Sousa João , Balasubramaniam Richard , Agarwal Sharad , Farwell David , Sopher Mark , Babu Girish , Till Richard , Jones Nikki , Tan Stuart , Chow Anthony , Lowe Martin , Lane Jem , Pappachan Naveen , Linton Nicholas , Kanagaratnam Prapa 
Published: August 2017

AbstractBackgroundRipple mapping (RM) displays electrograms as moving bars over a three‐dimensional surface displaying bipolar voltage, and has shown in a single‐center series to be effective for atrial tachycardia (AT) mapping without annotation of local activation time or window‐of‐interest assignment. We tested the reproducibility of these findings in operators naïve to RM, using it for the first time in postablation AT.MethodsMaps were collected with multielectrode catheters and CARTO ConfiDENSE. A diagnosis of the tachycardia mechanism was made using RM and an assessment of operator confidence was made according to a three‐grade scale (1 highest—3 lowest).ResultsThe first 20 patients (64 ± 9 years, median two previous ablations) undergoing RM‐guided AT ablation across five sites were studied. High‐density maps (2,935 ± 1,328 points) in AT (CL = 296 ± 95 milliseconds) were collected. Macroreentrant ATs bordered by scar or anatomical obstacles were identified in n = 12 (60%), small reentrant ATs around scar in n = 3 (15%), and focal ATs from scar in n = 5 (25%). Diagnostic confidence with RM was grade 1 in n = 13 (65%), where operators felt confident to proceed to ablation without entrainment. Ablation offered the correct diagnosis n = 18 (90%). Retrospective review of the accompanying LAT maps demonstrated potential sources for error related to the window of interest selection, interpolation, and differentiating regions of scar during tachycardia on the voltage map.ConclusionRM was easy to adopt by operators using it for the first time, and identified the correct target for ablation with high diagnostic confidence in most cases of complex AT.
Why “Animal (De)liberation” survives early criticism and is pivotal to public health
Authors: Deckers Jan 
Published: August 2017

SummaryIn 2016, the book Animal (De)liberation: Should the Consumption of Animal Products Be Banned? was published. This article aims to engage with the critique that this book has received and to clarify and reinforce its importance for human health. It is argued that the ideas developed in the book withstand critical scrutiny. As qualified moral veganism avoids the pitfalls of other moral positions on human diets, public health policies must be altered accordingly, subject to adequate political support for its associated vegan project.
Another piece in the progranulin puzzle: special binding between progranulin and prosaposin creates additional lysosomal access
Authors: Van Damme Philip 
Published: August 2017

AbstractLoss‐of‐function mutations in the gene encoding the growth factor progranulin cause degeneration of the ageing brain in a dose‐dependent manner. While heterozygous mutations result in adult onset frontotemporal dementia, the much rarer homozygous null mutations cause an early onset lysosomal storage disorder. A better understanding of the biology of progranulin in the central nervous system is needed to find solutions for these incurable diseases. This Editorial highlights a study by Zhou et al. in the current issue of the Journal of Neurochemistry, in which the authors provide data that are a step towards this goal. Progranulin is mainly expressed by neurons and microglia and, although it is a secreted protein, it also ends up in lysosomes. Recently, the trafficking of progranulin and the molecular players involved have become better understood. A special interaction between progranulin and its travelling companion, prosaposin, explains how both proteins can use each other's transport receptors to gain access to lysosomes.
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Early‐stage attenuation of phase‐amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of Alzheimer's disease
Authors: Bazzigaluppi Paolo , Beckett Tina L. , Koletar Margaret M. , Lai Aaron Y. , Joo Illsung L. , Brown Mary E. , Carlen Peter L. , McLaurin JoAnne , Stefanovic Bojana 
Published: August 2017

AbstractAlzheimer's disease (AD) is pathologically characterized by amyloid‐β peptide (Aβ) accumulation, neurofibrillary tangle formation, and neurodegeneration. Preclinical studies on neuronal impairments associated with progressive amyloidosis have demonstrated some Aβ‐dependent neuronal dysfunction including modulation of gamma‐aminobutyric acid‐ergic signaling. The present work focuses on the early stage of disease progression and uses TgF344‐ADrats that recapitulate a broad repertoire ofAD‐like pathologies to investigate the neuronal network functioning using simultaneous intracranial recordings from the hippocampus (HPC) and the medial prefrontal cortex (mPFC), followed by pathological analyses of gamma‐aminobutyric acid (GABAA) receptor subunits α1,α5, and δ, and glutamic acid decarboxylases (GAD65 andGAD67). Concomitant to amyloid deposition and tau hyperphosphorylation, low‐gamma band power was strongly attenuated in theHPCandmPFCof TgF344‐ADrats in comparison to those in non‐transgenic littermates. In addition, the phase‐amplitude coupling of the neuronal networks in both areas was impaired, evidenced by decreased modulation of theta band phase on gamma band amplitude in TgF344‐ADanimals. Finally, the gamma coherence betweenHPCandmPFCwas attenuated as well. These results demonstrate significant neuronal network dysfunction at an early stage ofAD‐like pathology. This network dysfunction precedes the onset of cognitive deficits and is likely driven by Aβ and tau pathologies.imageThis article is part of the Special Issue “Vascular Dementia”.
Morphology, topology and dimensions of the heart and arteries of genetically normal and mutant mouse embryos at stages S21–S23
Authors: Geyer Stefan H. , Reissig Lukas F. , Hüsemann Markus , Höfle Cordula , Wilson Robert , Prin Fabrice , Szumska Dorota , Galli Antonella , Adams David J. , White Jacqui , Mohun Timothy J. , Weninger Wolfgang J. 
Published: August 2017

AbstractAccurate identification of abnormalities in the mouse embryo depends not only on comparisons with appropriate, developmental stage‐matched controls, but also on an appreciation of the range of anatomical variation that can be expected during normal development. Here we present a morphological, topological and metric analysis of the heart and arteries of mouse embryos harvested on embryonic day (E)14.5, based on digital volume data of whole embryos analysed by high‐resolution episcopic microscopy (HREM). By comparing data from 206 genetically normal embryos, we have analysed the range and frequency of normal anatomical variations in the heart and major arteries across Theiler stages S21–S23. Using this, we have identified abnormalities in these structures among 298 embryos from mutant mouse lines carrying embryonic lethal gene mutations produced for the Deciphering the Mechanisms of Developmental Disorders (DMDD) programme. We present examples of both commonly occurring abnormal phenotypes and novel pathologies that most likely alter haemodynamics in these genetically altered mouse embryos. Our findings offer a reference baseline for identifying accurately abnormalities of the heart and arteries in embryos that have largely completed organogenesis.
Retracted: Molecular characterization of excipients’ preferential interactions with therapeutic monoclonal antibodies
Authors: Kim Jehoon , Krebs Mark R H , Trout Bernhardt L 
Published: August 2017

Abstract
Retraction: Molecular characterization of excipients’ preferential interactions with therapeutic monoclonal antibodies by Jehoon Kim, Mark R. H. Krebs and Bernhardt L. Trout
The above article from the Journal of Pharmacy and Pharmacology, first published online on 4 August 2017 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Professor David Jones, and John Wiley & Sons Ltd. The authors discovered that the analysis of simulations was faulty making the data incorrect.
Reference
Kim J et al. Molecular characterization of excipients’ preferential interactions with therapeutic monoclonal antibodies. J Pharm Pharmacol 2017. https://doi.org/10.1111/jphp.12787
Mechanisms involved in the cytotoxic action of Brazilian propolis and caffeic acid against HEp-2 cells and modulation of P-glycoprotein activity
Authors: da Silva Lívia M , Frión-Herrera Yahima , Bartolomeu Ariane R , Gorgulho Carolina Mendonça , Sforcin José M 
Published: August 2017

Abstract

Objectives
The effects of propolis and phenolic compounds (caffeic acid – Caf; dihydrocinnamic acid – Cin; p-coumaric acid – Cou) in the same quantity found in our propolis sample were investigated on human laryngeal epidermoid carcinoma (HEp-2) cells.

Methods
Cell viability, apoptosis/necrosis and cell cycle arrest, P53 and CASPASE-3 gene expression, generation of reactive oxygen species (ROS) and the ability of propolis to induce doxorubicin (DOX) efflux using a P-glycoprotein (P-gp) inhibitor (verapamil) were assayed.

Key findings
Propolis exerted a cytotoxic effect on HEp-2 cells, whereas isolated compounds had no effect on cell viability. Higher concentrations were tested and Caf induced late apoptosis or necrosis in HEp-2 cells, while propolis induced apoptosis, both probably due to ROS generation. P53 expression was downregulated by propolis but not by Caf. CASPASE-3 expression was correlated with induction of both early and late apoptosis, with both propolis and Caf alone upregulating its expression. Propolis induced cell cycle arrest at G2/M phase and Caf at S phase. Propolis but not Caf may act as a P-gp inhibitor by modulating P-gp activity and inhibiting DOX efflux.

Conclusions
Propolis exerted cytotoxic effects on HEp-2 cells, and the mechanisms are discussed, showing its potential as an antitumour drug.