bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive Application of Time-of-flight Secondary Ion Mass Spectrometry (TOF-SIMS) for Ionic Imaging and Bio-energetic Analysis of Club Drug-induced Cognitive Deficiency
Authors: Youn Su-Chung , Chen Li-You , Chiou Ruei-Jen , Lai Te-Jen , Liao Wen-Chieh , Mai Fu-Der , Chang Hung-Ming 
Published: December 2015

AbstractExcessive exposure to club drug (GHB) would cause cognitive dysfunction in which impaired hippocampal Ca2+-mediated neuroplasticity may correlate with this deficiency. However, the potential changes of in vivo Ca2+ together with molecular machinery engaged in GHB-induced cognitive dysfunction has never been reported. This study aims to determine these changes in bio-energetic level through ionic imaging, spectrometric, biochemical, morphological, as well as behavioral approaches. Adolescent rats subjected to GHB were processed for TOF-SIMS, immunohistochemistry, biochemical assay, together with Morris water maze to detect the ionic, molecular, neurochemical and behavioral changes of GHB-induced cognitive dysfunction, respectively. Extent of oxidative stress and bio-energetics were assessed by levels of lipid peroxidation, Na+/K+ ATPase, cytochrome oxidase and [14C]-2-deoxyglucose activity. Results indicated that in GHB intoxicated rats, decreased Ca2+ imaging and reduced NMDAR1, nNOS and p-CREB reactivities were detected in hippocampus. Depressed Ca2+-mediated signaling corresponded well with intense oxidative stress, diminished Na+/K+ ATPase, reduced COX and decreased 2-DG activity, which all contributes to the development of cognitive deficiency. As impaired Ca2+-mediated signaling and oxidative stress significantly contribute to GHB-induced cognitive dysfunction, delivering agent(s) that improves hippocampal bio-energetics may thus serve as a promising strategy to counteract the club drug-induced cognitive dysfunction emerging in our society nowadays.
Elevation of serum interleukins 8, 4 and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma
Authors: Miyata-Takata Tomoko , Takata Katsuyoshi , Toji Tomohiro , Goto Naoe , Kasahara Senji , Takahashi Takeshi , Tari Akira , Noujima-Harada Mai , Miyata Takafumi , Sato Yasuharu , Yoshino Tadashi 
Published: December 2015

AbstractProinflammatory cytokines that are produced by helper T cells (Th) regulate immune reactions, facilitate class switching of B cells and prolong the lifespan of B and T cells. Eradication therapy using antibiotics is sometimes effective against gastrointestinal (GI) malignant lymphoma, suggesting that the tumor development or progression is affected by the inflammatory microenvironment. In the present study, serum samples from 148 patients with various subtypes of malignant lymphoma were tested for 11 proinflammatory Th1/Th2 cytokines. In the comparison by subtype or GI lesions, serum interleukin (IL)-8 (P = 6.7E−05), IL-4 (P = 7.5E−05) and IL-1β (P = 0.0043) levels showed significant differences among subtypes, being particularly elevated in follicular lymphomas (FL) and mucosa-associated lymphoid tissue (MALT) lymphomas. Serum IL-8 levels were elevated in GI-FL and MALT lymphomas and serum IL-4 and IL-1 β levels were elevated in MALT lymphomas. These findings show that GI low-grade B-cell lymphoma could develop against the background of an inflammatory microenvironment. Thus, these cytokines may be useful as diagnostic markers and could provide new insights into tumor development.
Anti-breast tumor activity of Eclipta extract in-vitro and in-vivo: novel evidence of endoplasmic reticulum specific localization of Hsp60 during apoptosis
Authors: Arya Rakesh K. , Singh Akhilesh , Yadav Navneet K. , Cheruvu Srikanth H. , Hossain Zakir , Meena Sanjeev , Maheshwari Shrankhla , Singh Anup K. , Shahab Uzma , Sharma Chetan , Singh Kavita , Narender Tadigoppula , Mitra Kalyan , Arya Kamal R. , Singh Rama K. , Gayen Jiaur R. , Datta Dipak 
Published: December 2015

AbstractMajor challenges for current therapeutic strategies against breast cancer are associated with drug-induced toxicities. Considering the immense potential of bioactive phytochemicals to deliver non-toxic, efficient anti-cancer therapeutics, we performed bio-guided fractionation of Eclipta alba extract and discovered that particularly the chloroform fraction of Eclipta alba (CFEA) is selectively inducing cytotoxicity to breast cancer cells over non-tumorigenic breast epithelial cells. Our unbiased mechanistic hunt revealed that CFEA specifically activates the intrinsic apoptotic pathway by disrupting the mitochondrial membrane potential, upregulating Hsp60 and downregulating the expression of anti-apoptotic protein XIAP. By utilizing Hsp60 specific siRNA, we identified a novel pro-apoptotic role of Hsp60 and uncovered that following CFEA treatment, upregulated Hsp60 is localized in the endoplasmic reticulum (ER). To our knowledge, this is the first evidence of ER specific localization of Hsp60 during cancer cell apoptosis. Further, our LC-MS approach identified that luteolin is mainly attributed for its anti-cancer activities. Moreover, oral administration of CFEA not only offers potential anti-breast cancer effects in-vivo but also mitigates tumor induced hepato-renal toxicity. Together, our studies offer novel mechanistic insight into the CFEA mediated inhibition of breast cancer and may potentially open up new avenues for further translational research.
Kinetics of nucleotide-dependent structural transitions in the kinesin-1 hydrolysis cycle
Authors: Mickolajczyk Keith J. , Deffenbaugh Nathan C. , Ortega Arroyo Jaime , Andrecka Joanna , Kukura Philipp , Hancock William O. 
Published: December 2015

Significance
We use high spatiotemporal resolution single-molecule microscopy to directly visualize the structural transitions underlying each step of the molecular motor kinesin-1 at physiological stepping rates. Our results identify a one-head–bound intermediate in the stepping cycle that is initiated by ATP binding and is terminated by ATP hydrolysis. These results supersede previous functional studies because they identify the transitions that must occur to produce a step as opposed to transitions that may occur if the motor is studied under controlled conditions. We thus show that kinesin utilizes a two-step powerstroke mechanism to walk at maximum velocity. The single-molecule methods developed here are broadly applicable for resolving protein conformational changes as small as 2 nm with millisecond temporal resolution.
Dental Opioid Prescribing Practices and Risk Mitigation Strategy Implementation: Identification of Potential Targets for Provider-Level Intervention
Authors: McCauley Jenna L. , Leite Renata S. , Melvin Cathy L. , Fillingim Roger B. , Brady Kathleen T. 
Published: December 2015

Background Given the regular use of immediate-release opioids for dental pain management, as well as documented opioid misuse among dental patients, the dental visit may provide a viable point of intervention to screen, identify, and educate patients regarding the risks associated with prescription opioid misuse and diversion. The aims of this statewide survey of dental practitioners were to assess (a) awareness of the scope of prescription opioid misuse and diversion; (b) current opioid prescribing practices; (c) use of and opinions regarding risk mitigation strategies; and (d) use and perceived utility of drug monitoring programs. Methods This cross-sectional study surveyed dentists ( N = 87) participating in statewide professional and alumni organizations. Dentists were invited via e-mail and listserv announcement to participate in a one-time, online, 59-item, self-administered survey. Results A majority of respondents reported prescribing opioids ( n = 66; 75.8%). A minority of respondents ( n = 38; 44%) reported regularly screening for current prescription drug abuse. Dentists reported low rates of requesting prior medical records ( n = 5; 5.8%). Only 38% ( n = 33) of respondents had ever accessed a prescription drug monitoring program (PDMP), and only 4 (4.7%) consistently used a PDMP. Dentists reporting prior training in drug diversion were significantly more likely to have accessed their PDMP, P < .01. Interest in continuing education regarding assessment of prescription drug abuse/diversion and use of drug monitoring programs was high. Conclusions Although most dentists received training related to prescribing opioids, findings identified a gap in existing dental training in the assessment/identification of prescription opioid misuse and diversion. Findings also identified gaps in the implementation of recommended risk mitigation strategies, including screening for prescription drug abuse, consistent provision of patient education, and use of a PDMP prior to prescribing opioids.
Operative Strategies and Outcomes in Type a Aortic Dissection after the Enactment of a Multidisciplinary Aortic Surgery Team
Authors: Beller Jared P. , Scheinerman Joshua A. , Balsam Leora B. , Ursomanno Patricia , DeAnda Abe 
Published: December 2015

Objective The purpose of this study was to compare operative strategies and patient outcomes in acute type A aortic dissection (ATAAD) repairs before and after the implementation of a multi-disciplinary aortic surgery team. Methods Between May 2005 and July 2014, 101 patients underwent ATAAD repair at our institution. A dedicated multidisciplinary aortic surgery team (experienced aortic surgeon, perfusionists, cardiac anesthesiologists, nurses, and radiologists) was formed in 2010. We retrospectively compared ATAAD repair outcomes in patients before (2005–2009, N = 39) and after (2010–2014, N = 62) implementation of our program. Expected operative mortality was calculated using the International Registry of Acute Aortic Dissection preoperative predictive model. Results This study demonstrated a significant reduction in operative mortality after implementation of the aortic surgery program (30.8% vs. 9.7%; P = 0.014). There was also an increase in the complexity of surgical technique and perfusion strategies with fewer postoperative complications related to respiratory (P < 0.0001) and renal failure (P = 0.034). Baseline demographics were similar, and there was no statistically significant difference in International Registry of Acute Aortic Dissection predictive variables between the 2 groups. However, there was a 3.5-fold reduction in the observed-to-expected (O/E) operative mortality ratio. There was a 50% increase in volume with a significant number of patients being admitted directly to our aortic center for ATAAD repair, thus avoiding delay in operation related to transfers from a secondary hospital. Conclusions Patient outcomes are improved when the surgical treatment of ATAAD is managed by a high-volume multidisciplinary aortic surgery team.
The Brain Imaging Data Structure: a standard for organizing and describing outputs of neuroimaging experiments
Authors: Gorgolewski Krzysztof J. , Auer Tibor , Calhoun Vince D. , Cameron Craddock R. , Das Samir , Duff Eugene P. , Flandin Guillaume , Ghosh Satrajit S. , Glatard Tristan , Halchenko Yaroslav O. , Handwerker Daniel A. , Hanke Michael , Keator David , Li Xiangrui , Michael Zachary , Maumet Camille , Nichols B. Nolan , Nichols Thomas E. , Poline Jean-Baptiste , Rokem Ariel , Schaefer Gunnar , Sochat Vanessa , Triplett William , Turner Jessica A. , Varoquaux Gaël , Poldrack Russell A. 
Published: December 2015

AbstractThe development of magnetic resonance imaging (MRI) techniques has defined modern neuroimaging. Since its inception, tens of thousands of studies using techniques such as functional MRI and diffusion weighted imaging have allowed for the non-invasive study of the brain. Despite the fact that MRI is routinely used to obtain data for neuroscience research, there has been no widely adopted standard for organizing and describing the data collected in an imaging experiment. This renders sharing and reusing data (within or between labs) difficult if not impossible and unnecessarily complicates the application of automatic pipelines and quality assurance protocols. To solve this problem, we have developed the Brain Imaging Data Structure (BIDS), a standard for organizing and describing MRI datasets. The BIDS standard uses file formats compatible with existing software, unifies the majority of practices already common in the field, and captures the metadata necessary for most common data processing operations.
Approximation of the time-dependent induction equation with advection using Whitney elements
Authors: Nore Caroline , Zaidi Houda , Bouillault Frederic , Bossavit Alain , Guermond Jean-Luc 
Published: December 2015

Purpose
– The purpose of this paper is to present a new formulation for taking into account the convective term due to an imposed velocity field in the induction equation in a code based on Whitney elements called DOLMEN. Different Whitney forms are used to approximate the dependent variables. The authors study the kinematic dynamo action in a von Kármán configuration and obtain results in good agreement with those provided by another well validated code called SFEMaNS. DOLMEN is developed to investigate the dynamo action in non-axisymmetric domains like the impeller driven flow of the von Kármán Sodium (VKS) experiment. The authors show that a 3D magnetic field dominated by an axisymmetric vertical dipole can grow in a kinematic dynamo configuration using an analytical velocity field.

Design/methodology/approach
– Different Whitney forms are used to approximate the dependent variables. The vector potential is discretized using first-order edge elements of the first family. The velocity is approximated by using the first-order Raviart-Thomas elements. The time stepping is done by using the Crank-Nicolson scheme.

Findings
– The authors study the kinematic dynamo action in a von Kármán configuration and obtain results in good agreement with those provided by another well validated code called SFEMaNS. The authors show that a 3D magnetic field dominated by an axisymmetric vertical dipole can grow in a kinematic dynamo configuration using an analytical velocity field.

Originality/value
– The findings offer a basis to a scenario for the VKS dynamo.
Inter-turn short-circuit fault detection in saturable squirrel-cage induction motor using magnetic equivalent circuit model
Authors: Naderi Peyman 
Published: December 2015

Purpose
– The purpose of this paper is to obtain an integrated method for inter-turn short circuit fault detection for the cage-rotor induction machine (CRIM) considering saturation effect.

Design/methodology/approach
– The magnetic equivalent circuit (MEC) is proposed for machine modeling and nonlinear B-H curve is considered for saturation effect. The machine has some differential equations which are converted to algebraic type by trapezoidal method. On the other hand, some nonlinear equations are present due to saturation effect. A set of nonlinear algebraic equation should be solved by numerical method. Therefore, the Newton-Raphson technique is used for equation solving during of the considered time step.

Findings
– Generally, the operating point of electrical machines is close to the saturation zone due to designing considerations. Moreover, some current and torque harmonics will be produced due to time and space harmonics combination, which cannot be studied when saturation modeling is neglected. Considering both space and time harmonics, a method is proposed for inter-turn short circuit fault detection based on the stator current signatures and the machine performance is analyzed in healthy and faulty cases. In order to obtain the integrated method, two sample machines (two and also four-pole machines) are modeled and finally the accuracy of the proposed method is verified through the experimental results.

Research limitations/implications
– The calculations have been done in this work is limited to CRIM considering. However, the presented modeling method can be used for another types of electrical machines by some minor modifications.

Originality/value
– Obtaining of an integrated formula for the inter-turn short circuit fault detection which has been presented for first time is the more advantages of present work. Moreover, in order to saturation effect considering, a new method is presented for solving of nonlinear equations which is another novelty of paper.
Electric field distribution and voltage breakdown modeling for any PN junction
Authors: Rouger N. 
Published: December 2015

Purpose
– Scientists and engineers have been solving Poisson’s equation in PN junctions following two approaches: analytical solving or numerical methods. Although several efforts have been accomplished to offer accurate and fast analyses of the electric field distribution as a function of voltage bias and doping profiles, so far none achieved an analytic or semi-analytic solution to describe neither a double diffused PN junction nor a general case for any doping profile. The paper aims to discuss these issues.

Design/methodology/approach
– In this work, a double Gaussian doping distribution is first considered. However, such a doping profile leads to an implicit problem where Poisson’s equation cannot be solved analytically. A method is introduced and successfully applied, and compared to a finite element analysis. The approach is then generalized, where any doping profile can be considered. 2D and 3D extensions are also presented, when symmetries occur for the doping profile.

Findings
– These results and the approach here presented offer an efficient and accurate alternative to numerical methods for the modeling and simulation of mathematical equations arising in physics of semiconductor devices.

Research limitations/implications
– A general 3D extension in the case where no symmetry exists can be considered for further developments.

Practical implications
– The paper strongly simplify and ease the optimization and design of any PN junction.

Originality/value
– This paper provides a novel method for electric field distribution analysis.
Static security enhancement using fuzzy particle swarm optimization
Authors: Pandiarajan K. , Babulal C.K. 
Published: December 2015

Purpose
– The electric power system is a complex system, whose operating condition may not remain at a constant value. The various contingencies like outage of lines, transformers, generators and sudden increase of load demand or failure of equipments are more common. This causes overloads and system parameters to exceed the limits thus resulting in an insecure system. The purpose of this paper is to enhance the power system security by alleviating overloads on the transmission lines.

Design/methodology/approach
– Fuzzy logic system (FLS) with particle swarm optimization based optimal power flow approach is used for overload alleviation on the transmission lines. FLS is modeled to find the changes in inertia weight by which new weights are determined and their values are applied to particle swarm optimization (PSO) algorithm for velocity and position updation.

Findings
– The proposed method is tested and examined on the standard IEEE-30 bus system under base case and increased load conditions at different contingency. This method gives better results in terms of optimum fuel cost and fast convergence under base case and could alleviate the line overloads at different contingency with optimum generation cost, when compared to adaptive particle swarm optimization (APSO) and PSO.

Originality/value
– FLS is modeled in MATLAB environment. The effectiveness of the proposed method is tested and examined on the standard IEEE-30 bus system and their results are compared with APSO and PSO under MATPOWER environment. The results show that the proposed algorithm is capable of improving the transmission security with optimum generation cost.
Energy conversion performance investigations for a horizontal evacuated tubular collector
Authors: Zhao Chunyu , You Shijun , Gao Hao , Yu Wei 
Published: December 2015

Purpose
– The purpose of this paper is to use numerical simulations to investigate the energy conversion performance and the flow and temperature structures inside horizontal tubes connected to a vertical manifold channel.

Design/methodology/approach
– The simulations are performed for different flow rates and inlet temperatures using CFD.

Findings
– In both the “flowing wind mode” and “upwind mode,” the inlet velocity is not infinitely small under the influence of natural convection; however, such small inlet velocities cannot be achieved in practice and are of no practical significance. In the “flowing wind mode,” the appropriate velocity for achieving high efficiency is 0.01-0.02 m/s. In the “upwind mode,” the appropriate velocity for obtaining high efficiency is 0.1-0.2 m/s. A high inlet temperature can lead to high efficiency; therefore, a large temperature difference and a small flow can be used in actual designs.

Originality/value
– The energy conversion performance and flow structures inside evacuated tubular collectors were investigated using CFD for different operating conditions, notably in the “following wind mode” and the “upwind mode.”
Numerical simulation of transient forced convection in a square enclosure containing two heated circular cylinders
Authors: Karimi Talkhoncheh Fariborz , Xu Hongtao , Wang Zhiyun , Yang Mo , Zhang Yuwen 
Published: December 2015

Purpose
– Unsteady simulation of forced convection of two heated horizontal cylinders confined in a 2D squared enclosure. The paper aims to discuss this issue.

Design/methodology/approach
– The finite-volume method is used to solve the transient heat transfer problem by employing quadrilateral mesh type. To solve the governing equations (conservations of mass, momentum and energy) on unstructured control volumes, a second-order quadratic upwind interpolation of convective kinematics scheme for the convection terms and the semi-implicit method for pressure-linked equations pressure correction algorithm were used.

Findings
– The results indicate that the variation of the area-averaged Nusselt number strongly depends on the Reynolds number. On the contrary, the effect of cylinders’ space on heat transfer was found to be nearly negligible for Re
<
460. It is also observed that steady state flow and heat transfer shift to periodical oscillation, and ultimately chaotic oscillation in non-dimensional cylinders distance of 0.1; however the sequence of appearing this route is completely different for higher cylinder spaces.

Research limitations/implications
– Reynolds numbers between 380 and 550 and dimensionless horizontal distances of cylinders 0.1, 0.2 and 0.3.

Originality/value
– Comprehensive knowledge of the effect of tube arrays flow regime on each other and in turn, heat transfer among them. Better understanding of convective heat transfer around an array of horizontal cylinders compared with from those around a single cylinder because of the mutual interaction of the buoyant plumes generated by the cylinders. Time-dependent phenomena of the problem including periodical oscillation or chaotic features.