bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apple intake is inversely associated with all-cause and disease-specific mortality in elderly women
Authors: Hodgson Jonathan M. , Prince Richard L. , Woodman Richard J. , Bondonno Catherine P. , Ivey Kerry L. , Bondonno Nicola , Rimm Eric B. , Ward Natalie C. , Croft Kevin D. , Lewis Joshua R. 
Published: January 2016

AbstractHigher fruit intake is associated with lower risk of all-cause and disease-specific mortality. However, data on individual fruits are limited, and the generalisability of these findings to the elderly remains uncertain. The objective of this study was to examine the association of apple intake with all-cause and disease-specific mortality over 15 years in a cohort of women aged over 70 years. Secondary analyses explored relationships of other fruits with mortality outcomes. Usual fruit intake was assessed in 1456 women using a FFQ. Incidence of all-cause and disease-specific mortality over 15 years was determined through the Western Australian Hospital Morbidity Data system. Cox regression was used to determine the hazard ratios (HR) for mortality. During 15 years of follow-up, 607 (41·7 %) women died from any cause. In the multivariable-adjusted analysis, the HR for all-cause mortality was 0·89 (95 % CI 0·81, 0·97) per sd (53 g/d) increase in apple intake, HR 0·80 (95 % CI 0·65, 0·98) for consumption of 5–100 g/d and HR 0·65 (95 % CI 0·48, 0·89) for consumption of >100 g/d (an apple a day), compared with apple intake of <5 g/d (Pfor trend=0·03). Our analysis also found that higher apple intake was associated with lower risk for cancer mortality, and that higher total fruit and banana intakes were associated lower risk of CVD mortality (P<0·05). Our results support the view that regular apple consumption may contribute to lower risk of mortality.
Unlike pregnant adult women, pregnant adolescent girls cannot maintain glycine flux during late pregnancy because of decreased synthesis from serine
Authors: Hsu Jean W. , Thame Minerva M. , Gibson Raquel , Baker Tameka M. , Tang Grace J. , Chacko Shaji K. , Jackson Alan A. , Jahoor Farook 
Published: January 2016

AbstractDuring pregnancy, glycine and serine become more important because they are the primary suppliers of methyl groups for the synthesis of fetal DNA, and more glycine is required for fetal collagen synthesis as pregnancy progresses. In an earlier study, we reported that glycine flux decreased by 39 % from the first to the third trimester in pregnant adolescent girls. As serine is a primary precursor for glycine synthesis, the objective of this study was to measure and compare glycine and serine fluxes and inter-conversions in pregnant adolescent girls and adult women in the first and third trimesters. Measurements were made after an overnight fast by continuous intravenous infusions of 2H2-glycine and 15N-serine in eleven adolescent girls (17·4 (se 0·1) years of age) and in ten adult women (25·8 (se 0·5) years of age) for 4 h. Adolescent girls had significantly slower glycine flux and they made less glycine from serine in the third (P<0·05) than in the first trimester. Baby birth length was significantly shorter of adolescent girls (P=0·04) and was significantly associated with third trimester glycine flux. These findings suggest that the pregnant adolescent cannot maintain glycine flux in late pregnancy compared with early pregnancy because of decreased synthesis from serine. It is possible that the inability to maintain glycine synthesis makes her fetus vulnerable to impaired cartilage synthesis, and thus linear growth.
Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial
Authors: Shi Yuanlu , Williamson Gary 
Published: January 2016

AbstractElevated plasma uric acid concentration is a risk factor for gout, insulin resistance and type 2 diabetes. Quercetin, a flavonoid found in high levels in onions, tea and apples, inhibits xanthine oxidoreductasein vitro, the final step in intracellular uric acid production, indicating that quercetin might be able to lower blood uric acid in humans. We determined the effects of 4 weeks of oral supplementation of quercetin on plasma uric acid, blood pressure and fasting glucose. This randomised, double-blinded, placebo-controlled, cross-over trial recruited twenty-two healthy males (19–60 years) with baseline plasma uric acid concentration in the higher, but still considered healthy, range (339 (sd51) µmol/l). The intervention included one tablet containing 500 mg quercetin daily for 4 weeks, compared with placebo, with a 4-week washout period between treatments. The primary outcome was change in concentrations of plasma uric acid after 2 and 4 weeks; secondary outcome measures were changes in fasting plasma glucose, 24-h urinary excretion of uric acid and resting blood pressure. After quercetin treatment, plasma uric acid concentrations were significantly lowered by −26·5 µmol/l (95 % CI, −7·6, −45·5;P=0·008), without affecting fasting glucose, urinary excretion of uric acid or blood pressure. Daily supplementation of 500 mg quercetin, containing the bioavailable amount of quercetin as present in approximately 100 g red onions, for 4 weeks, significantly reduces elevated plasma uric acid concentrations in healthy males.
Reproducibility and validity of an FFQ developed for adults in Nanjing, China
Authors: Ye Qing , Hong Xin , Wang Zhiyong , Yang Huafeng , Chen Xupeng , Zhou Hairong , Wang Chenchen , Lai Yichao , Sun Liuyuan , Xu Fei 
Published: January 2016

AbstractWe evaluated the reproducibility and validity of an FFQ used in a Chinese community-based nutrition and health survey. A total of ninety-nine males and 104 females aged 31–80 years completed four three consecutive 24-h dietary recalls (24-HDR, served as a reference method, one three consecutive 24-HDR for each season) and two FFQ (FFQ1 and FFQ2) over a 1-year interval. The reproducibility of the FFQ was estimated with correlation coefficients, misclassification and weighted κ statistic. The validity was evaluated by comparing the data obtained from FFQ2 with the mean 24-HDR (m24-HDR). Compared with the m24-HDR, the FFQ tended to underestimate intake of most nutrients and food groups. For all nutrients and food groups, the Spearman’s and intra-class correlation coefficients between FFQ1 and FFQ2 ranged from 0·66 to 0·88 and from 0·65 to 0·87, respectively. Most correlation coefficients decreased after adjusting for energy. More than 90 % of the subjects were classified into the same or adjacent categories by both FFQ. For all nutrients and food groups, the crude, energy-adjusted and de-attenuated Spearman’s correlation coefficients between FFQ2 and the m24-HDR ranged from 0·21 to 0·69, 0·19 to 0·58 and 0·25 to 0·71, respectively. More than 70 % of the subjects were classified into the same and adjacent categories by both instruments. Both weighted κ statistic and the Bland–Altman plots showed reasonably acceptable agreement between the FFQ2 and the m24-HDR. The FFQ developed for adults in the Nanjing area can be used to reliably and validly measure usual intake of major nutrients and food groups.
Rethinking Foreign Military Interventions to Promote Human Rights: Evidence from Libya, Bahrain and Syria
Authors: Nuruzzaman Mohammed 
Published: January 2016

AbstractScholarly opinions on the linkages between foreign military interventions and human rights promotions or violations are highly divided across the board. While many scholars see military interventions as effective means to save and promote human lives and rights from the clutches of repressive regimes, others reject such interventions as harmful to domestic reconciliations and rights promotions. The Arab Spring has renewed the debates between the liberal enthusiasts who staunchly supported NATO's military intervention to free up the Libyans from the Gaddafi regime and the critics who saw creeping dangers in this new intervention, ostensibly inspired by the “responsibility to protect” doctrine. This paper investigates the issue of Arab Spring-led foreign direct and indirect military interventions in Libya, Bahrain and Syria and critically examines the consequences of interventions for improvements or decline in Arab human rights conditions. Its findings support the position of the anti-intervention scholars that foreign military interventions produce deleterious effects on human rights in the target states.
Nationalism, “Philosemitism,” and Symbolic Boundary-Making in Contemporary Poland
Authors: Zubrzycki Geneviève 
Published: January 2016

AbstractThis article analyzes the growing interest in Jews and all things Jewish in contemporary Poland—from the spectacular popularity of festivals of Jewish culture to the opening of Judaica bookstores and Jewish cuisine restaurants; from the development of Jewish studies programs at various universities and the creation of several museums to artists’ and public intellectuals’ engagements with Poland's Jewish past and Polish-Jewish relations more broadly. Drawing on ethnographic fieldwork, over sixty formal interviews with Jewish and non-Jewish activists, and informal conversations with participants in various Jewish-centered initiatives, I argue that this cultural phenomenon is related to the attempt by specific political and social groups to build a pluralistic society in an ethnically and denominationally homogenous nation-state. I build on the literature on nationalism and symbolic boundaries by showing that bringing back Jewish culture and “resurrecting the Jew” is a way to soften, stretch, and reshape the symbolic boundaries of the nation that the Right wants to harden and shrink using Catholicism as its main tool.
Notes on a Scandal: Transregional Networks of Violence, Gossip, and Imperial Sovereignty in the Late Eighteenth-Century Ottoman Empire
Authors: Esmer Tolga U. 
Published: January 2016

AbstractThis essay reconstructs a scandal in the fall of 1797 involving Ottoman governors, leaders of a notorious network of irregular soldiers cum bandits, and residents of the city of Filibe (Plovdiv in Bulgaria). It erupted over whether or not state officials should pacify successful bandit enterprises by co-opting their leaders. The scandal escalated into a crisis in which the large armies of the governors of Anatolia and Rumeli (the Ottoman Balkans) verged on clashing because each wanted to lead the state's lucrative war against Rumeli bandit networks. Imperial administrators issued dispatches regarding this scandal that were based on gossip and rumor circulating within the general population as well as among bandits. I draw on understandings of gossip as a social and cultural resource from linguistic anthropology to make sense of Ottoman political culture. I analyze these dispatches to uncover how the performance of these informal scripts featured prominently in correspondence with the Imperial Council and related surveillance reports, and thereby mediated resources, power, and authority among different agents of imperial violence. I show that gossip, rumor, and related forms of seemingly informal “talk” played a fundamental role in sovereign decision making. I also transpose methodologies and approaches of “history from below,” conceived by earlier generations of cultural anthropologists and historians, onto elite letters to ask new questions about information brokerage, the negotiation of power among different agents of imperial violence and their interlocutors, and the contested nature of imperial intelligence gathering and sovereignty.
Constructing a Kongo Identity: Scholarship and Mythopoesis
Authors: MacGaffey Wyatt 
Published: January 2016

AbstractThe past thirty years have seen, particularly in the United States, a transformation in the public image of “Kongo,” an ill-defined entity (a tribe, a kingdom, a culture, a region?) on the Atlantic coast of Central Africa. The efforts of R. F. Thompson, professor of art history at Yale, and A. Fu-kiau, himself Kongolese, have done much to popularize a “Kongo” characterized more by its romantic appeal than by historical or ethnographic verisimilitude. Elsewhere in the Americas, the reputation of “Kongo” has suffered by comparison with “Yoruba,” another historically emergent Atlantic identity, based in West Africa. These identities, and the supposed contrast between them, are products of an increasingly complex trans-Atlantic discourse.
The potential of milk fatty acids as biomarkers for methane emissions in dairy cows: a quantitative multi-study survey of literature data
Authors: CASTRO-MONTOYA J. M. , DE CAMPENEERE S. , DE BAETS B. , FIEVEZ V. 
Published: January 2016

SUMMARYRelationships between milk fatty acids (MFA) and methane (CH4) emissions from dairy cattle were explored. Data from a total of 12 studies including 39 treatments were gathered in the database. Methane was expressed as daily emissions (g/d), relative to dry matter intake (g/kg), milk production (g/kg milk) and body weight (g/kg). The univariate correlations between MFA and CH4 were based on absolute means and on relative changes of each treatment compared with its corresponding control. Saturated fatty acids, odd- and branched-chain FA and long-chain poly-unsaturated FA were positively related to CH4, while cis- and trans-isomers of mono-unsaturated FA were negatively related to CH4. However, most of the coefficients of determination (R2) of these univariate regressions ranged from 0·2 to 0·7, indicating that individual MFA only explain a limited part of the variation in CH4. Significant relationships between MFA and CH4 varied depending on the unit in which emissions were expressed. Similarly, some MFA seemed more suited to predict relative changes in CH4 emissions rather than absolute amounts. The present findings contribute to the exploration of the potential of MFA as biomarkers for CH4 emissions from dairy cattle, although differences between studies in the detail of MFA analysis and hence the number of MFA reported in the current study, complicates this kind of literature survey.
Disruptive mood dysregulation disorder at the age of 6 years and clinical and functional outcomes 3 years later
Authors: Dougherty L. R. , Smith V. C. , Bufferd S. J. , Kessel E. M. , Carlson G. A. , Klein D. N. 
Published: January 2016

BackgroundLittle is known about the predictive validity of disruptive mood dysregulation disorder (DMDD). This longitudinal, community-based study examined associations of DMDD at the age of 6 years with psychiatric disorders, functional impairment, peer functioning and service use at the age of 9 years.MethodA total of 473 children were assessed at the ages of 6 and 9 years. Child psychopathology and functional impairment were assessed at the age of 6 years with the Preschool Age Psychiatric Assessment with parents and at the age of 9 years with the Kiddie-Schedule of Affective Disorders and Schizophrenia (K-SADS) with parents and children. At the age of 9 years, mothers, fathers and youth completed the Child Depression Inventory (CDI) and the Screen for Child Anxiety Related Disorders, and teachers and K-SADS interviewers completed measures of peer functioning. Significant demographic covariates were included in all models.ResultsDMDD at the age of 6 years predicted a current diagnosis of DMDD at the age of 9 years. DMDD at the age of 6 years also predicted current and lifetime depressive disorder and attention-deficit/hyperactivity disorder (ADHD) at the age of 9 years, after controlling for all age 6 years psychiatric disorders. In addition, DMDD predicted depressive, ADHD and disruptive behavior disorder symptoms on the K-SADS, and maternal and paternal reports of depressive symptoms on the CDI, after controlling for the corresponding symptom scale at the age of 6 years. Last, DMDD at the age of 6 years predicted greater functional impairment, peer problems and educational support service use at the age of 9 years, after controlling for all psychiatric disorders at the age of 6 years.ConclusionsChildren with DMDD are at high risk for impaired functioning across childhood, and this risk is not accounted for by co-morbid conditions.
Ethical Dilemmas in Postnatal Treatment of Severe Congenital Hydrocephalus
Authors: WILKINSON DOMINIC 
Published: January 2016

Abstract:Severe congenital hydrocephalus manifests as accumulation of a large amount of excess fluid in the brain. It is a paradigmatic example of a condition in which diagnosis is relatively straightforward and long-term survival is usually associated with severe disability. It might be thought that, should parents agree, palliative care and limitation of treatment would be clearly permissible on the basis of the best interests of the infant. However, severe congenital hydrocephalus illustrates some of the neuroethical challenges in pediatrics. The permissibility of withholding or withdrawing treatment is limited by uncertainty in prognosis and the possibility of “palliative harm.” Conversely, although there are some situations in which treatment is contrary to the interests of the child, or unreasonable on the grounds of limited resources, acute surgical treatment of hydrocephalus rarely falls into that category.
Thriving in Adversity
Authors: SHELDON CURTIS 
Published: January 2016

Abstract:This article is intended to highlight the unique vulnerability associated with a
severe medical illness. It outlines important considerations that are relevant
to patients but perhaps especially relevant to medical providers. There are many
factors that contribute to recovery from a life-threatening illness. Essential,
but underestimated, factors include (1) a vision for what the meaning of your
life can be; (2) simple and unexpected acts of kindness that underscore the
commitment of your providers to your well-being; and (3) the character of
providers and the culture of the institution, which vary tremendously and are
palpable to the patient.
Glial fibrillary acidic protein as a biomarker for brain injury in neonatal CHD
Authors: McKenney Stephanie L. , Mansouri Fahad F. , Everett Allen D. , Graham Ernest M. , Burd Irina , Sekar Priya 
Published: January 2016

AbstractNeonates with critical CHD have evidence, by imaging, of preoperative brain injury, although the timing is unknown. We used circulating postnatal serum glial fibrillary acidic protein as a measure of acute perinatal brain injury in neonates with CHD. Glial fibrillary acidic protein was measured on admission and daily for the first 4 days of life in case and control groups; we included two control groups in this study – non-brain-injured newborns and brain-injured newborns. Comparisons were performed using the Kruskal–Wallis test with Dunn’s multiple comparisons, Student’s t-test, and χ2 test of independence where appropriate. In aggregate, there were no significant differences in overall glial fibrillary acidic protein levels between CHD patients (n=56) and negative controls (n=23) at any time point. By day 4 of life, 7/56 (12.5%) CHD versus 0/23 (0%) normal controls had detectable glial fibrillary acidic protein levels. Although not statistically significant, the 5/10 (50%) left heart obstruction group versus 1/17 (6%) conoventricular, 0/13 (0%) right heart, and 1/6 (17%) septal defect patients trended towards elevated levels of glial fibrillary acidic protein at day 4 of life. Overall, glial fibrillary acidic protein reflected no evidence for significant peripartum brain injury in neonates with CHD, but there was a trend for elevation by postnatal day 4 in neonates with left heart obstruction. This pilot study suggests that methods such as monitoring glial fibrillary acidic protein levels may provide new tools to optimise preoperative care and neuroprotection in high-risk neonates with specific types of CHD.
Computer-aided auscultation of murmurs in children: evaluation of commercially available software
Authors: Lee Cecilia , Rankin Kathryn N. , Zuo Kevin J. , Mackie Andrew S. 
Published: January 2016

AbstractBackgroundHeart murmurs are common in children and may represent congenital or acquired cardiac pathology. Auscultation is challenging and many primary-care physicians lack the skill to differentiate innocent from pathologic murmurs. We sought to determine whether computer-aided auscultation (CardioscanTM) identifies which children require referral to a cardiologist.MethodsWe consecutively enrolled children aged between 0 and 17 years with a murmur, innocent or pathologic, being evaluated in a tertiary-care cardiology clinic. Children being evaluated for the first time and patients with known cardiac pathology were eligible. We excluded children who had undergone cardiac surgery previously or were unable to sit still for auscultation. CardioscanTMauscultation was performed in a quiet room with the subject in the supine position. The sensitivity and specificity of a potentially pathologic murmur designation by CardioscanTM– that is, requiring referral – was determined using echocardiography as the reference standard.ResultsWe enrolled 126 subjects (44% female) with a median age of 1.7 years, with 93 (74%) having cardiac pathology. The sensitivity and specificity of a potentially pathologic murmur determination by CardioscanTMfor identification of cardiac pathology were 83.9 and 30.3%, respectively, versus 75.0 and 71.4%, respectively, when limited to subjects with a heart rate of 50–120 beats per minute. The combination of a CardioscanTMpotentially pathologic murmur designation or an abnormal electrocardiogram improved sensitivity to 93.5%, with no haemodynamically significant lesions missed.ConclusionsSensitivity of CardioscanTMwhen interpreted in conjunction with an abnormal electrocardiogram was high, although specificity was poor. Re-evaluation of computer-aided auscultation will remain necessary as advances in this technology become available.
Longitudinal Evaluation of Cognitive Functioning in Young Children with Type 1 Diabetes over 18 Months
Authors: Cato M. Allison , Mauras Nelly , Mazaika Paul , Kollman Craig , Cheng Peiyao , Aye Tandy , Ambrosino Jodie , Beck Roy W. , Ruedy Katrina J. , Reiss Allan L. , Tansey Michael , White Neil H. , Hershey Tamara 
Published: January 2016

AbstractObjectives:Decrements in cognitive function may already be evident in young children with type 1 diabetes (T1D). Here we report prospectively acquired cognitive results over 18 months in a large cohort of young children with and without T1D.Methods:A total of 144 children with T1D (mean HbA1c: 7.9%) and 70 age-matched healthy controls (mean age both groups 8.5 years; median diabetes duration 3.9 years; mean age of onset 4.1 years) underwent neuropsychological testing at baseline and after 18-months of follow-up. We hypothesized that group differences observed at baseline would be more pronounced after 18 months, particularly in those T1D patients with greatest exposure to glycemic extremes.Results:Cognitive domain scores did not differ between groups at the 18 month testing session and did not change differently between groups over the follow-up period. However, within the T1D group, a history of diabetic ketoacidosis (DKA) was correlated with lower Verbal IQ and greater hyperglycemia exposure (HbA1c area under the curve) was inversely correlated to executive functions test performance. In addition, those with a history of both types of exposure performed most poorly on measures of executive function.Conclusions:The subtle cognitive differences between T1D children and nondiabetic controls observed at baseline were not observed 18 months later. Within the T1D group, as at baseline, relationships between cognition (Verbal IQ and executive functions) and glycemic variables (chronic hyperglycemia and DKA history) were evident. Continued longitudinal study of this T1D cohort and their carefully matched healthy comparison group is planned. (JINS, 2016,21, 293–302)