bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of pregnancy outcome and decline of anti‐Müllerian hormone after laparoscopic cystectomy for ovarian endometriomas
Authors: Taniguchi Fuminori , Sakamoto Yasuko , Yabuta Yuko , Azuma Yukihiro , Hirakawa Eriko , Nagira Kei , Uegaki Takashi , Deura Imari , Hata Koukichi , Harada Tasuku 
Published: August 2016

AbstractAimExcision of ovarian endometrioma (OE) may induce the reduction of ovarian reserve. We evaluated pregnancy outcomes after laparoscopic cystectomy (LC), and the pre‐ and postoperative levels of anti‐Müllerian hormone (AMH) to consider the ovarian reserve.MethodsWe enrolled 40 women with OE and 16 women with benign ovarian tumors who hoped to have a child and who underwent LC. To evaluate the ovarian reserve of 40 patients (OE group, n = 24; non‐OE group, n = 16), we measured serum AMH levels before and after the surgery.ResultsIn the 40 women who underwent LC for OE, the cumulative pregnancy rate was 50%. Prior to the cystectomy, serum AMH levels in the OE group, especially in patients over the age of 35, were significantly lower than those in the non‐OE group. Rate of decline in serum AMH in the OE group was significant compared with that in the non‐OE group 6 months after surgery. In patients over the age of 35 in the OE group, AMH levels 1 year after surgery decreased noticeably.ConclusionLC for OE could be a preferred surgical approach, but effective therapeutic strategies will have to be developed to prevent damage to the ovarian reserve, especially for older patients.
Survey of attitudes of Chinese perinatologists and obstetricians toward non‐invasive prenatal genetic testing
Authors: Zhai Jinguo , Cai Wenzhi , Li Cuilan , Chen Min , Huang Lijuan , Zhong Mei 
Published: August 2016

AbstractAimThe clinical application of non‐invasive prenatal testing (NIPT) is still very limited in China. We carried out a survey to assess the willingness of Chinese obstetricians to offer NIPT and to determine how they would implement it and what resources they would need for the testing.MethodsBetween June 2014 and June 2015, a survey was conducted at a large academic referral center with data obtained from 392 registered perinatologists and obstetricians who completed an entire questionnaire.ResultsMost respondents (72.5%) agreed or strongly agreed that the percentage of women patients refusing to accept NIPT would increase if they were charged directly for the test. Most respondents (82.7%) answered affirmatively that the national health administration agencies should formulate a standard charge for NIPT. The most important factors that influence the application of NIPT are the popularity of the test and its cost. The majority of respondents indicated that there are appropriate reasons for NIPT.ConclusionThe importance of NIPT and guidelines for the application of NIPT should be clarified in current clinical practice in China. Extensive education regarding NIPT application is necessary prior to mass implementation.
Perinatal outcomes of abnormal umbilical coiling according to a modified umbilical coiling index
Authors: Ohno Yasumasa , Terauchi Mikio , Tamakoshi Koji 
Published: August 2016

AbstractAimThe aim of this study was to determine the relation between perinatal outcomes and umbilical cord coiling as evaluated by a modified umbilical coiling index.MethodsIn this retrospective study, 200 consecutive umbilical cords were examined. An umbilical venous and arterial coiling index was calculated by dividing the total number of umbilical venous and arterial coils by the length of cord individually. Umbilical cords with umbilical venous coiling indices in the lowest decile, the highest decile, and the remaining deciles were defined as hypocoiled, hypercoiled, and normocoiled, respectively. The perinatal outcomes of the subjects with hypocoiled and hypercoiled umbilical cords were compared with those with normocoiled umbilical cords.ResultsIn 69.5% of subjects, a difference in the degree of coiling was detected between the umbilical veins and arteries. While all umbilical venous twisting demonstrated the same direction, the direction of the arterial twisting reversed at a certain point along the umbilical cord in 19.0% of the subjects. The arteriovenous coiling difference was small in the hypercoiled group and large in the hypocoiled group. A hypocoiled umbilical cord evaluated by umbilical venous coiling index was found to be associated with prolonged deceleration (odds ratio [OR], 4.18; 95% confidence interval [CI], 1.54–11.38), operative delivery (OR, 2.67; 95%CI, 1.01–7.09), and nuchal cord entanglement (OR, 3.21; 95%CI, 1.23–8.33).ConclusionUmbilical coiling abnormalities were investigated using a novel umbilical venous coiling index. A hypocoiled umbilical cord evaluated by umbilical venous coiling index was found to be associated with fetal heart rate abnormalities, operative delivery, and nuchal cord entanglement.
Current status of fetal neurodevelopmental assessment: Four‐dimensional ultrasound study
Authors: Hata Toshiyuki 
Published: August 2016

AbstractWith the latest advent of four‐dimensional (4‐D) ultrasound, fetal neurobehavioral or neurodevelopmental assessment can be easily and readily performed. Using this technique, typical fetal movements and behavioral patterns have become apparent in all three trimesters of pregnancy. In twin pregnancy, 4‐D ultrasound facilitates the precise evaluation of inter‐twin contact and intra‐pair stimulation. New fetal neurobehavioral assessment tests, such as Kurjak's Antenatal Neurodevelopmental Test and the Fetal Observable Movement System, may reflect the normal and abnormal neurological development of the fetus, and will facilitate more precise assessments of fetal neurobehavior or neurodevelopment, and fetal brain and central nervous system functions. In this review article, I also discuss interesting topics regarding maternal and fetal stress, fetal pain, and fetal consciousness. Four‐dimensional ultrasound has opened the door to new scientific fields, such as ‘fetal neurology’ and ‘fetal psychology,’ and fetal neurobehavioral science is at the dawn of a new era. Knowledge on fetal neurobehavior and neurodevelopment will be advanced through fetal behavioral research using this technique.
Oncologic and obstetric outcomes of early stage cervical cancer with abdominal radical trachelectomy: Single‐institution experience
Authors: Tamauchi Satoshi , Kajiyama Hiroaki , Sakata Jun , Sekiya Ryuichiro , Suzuki Shiro , Mizuno Mika , Utsumi Fumi , Niimi Kaoru , Kotani Tomomi , Shibata Kiyosumi , Kikkawa Fumitaka 
Published: August 2016

AbstractAimRadical trachelectomy (RT) is a widely used fertility‐sparing treatment for patients with early cervical cancer (CCA). RT, however, is an investigational treatment, and its gynecological and obstetric efficacy are being investigated. We retrospectively assessed the efficacy of abdominal RT (ART) as a fertility‐sparing surgery.MethodsFrom 2010 to 2014, patients with stage IA2–IB1 CCA (tumor ≤2 cm) who wished to preserve their fertility underwent ART. The major outcomes were mortality, recurrence, pregnancy complications, and obstetric outcome.ResultsTwenty‐eight patients received ART. Adjuvant chemotherapy was performed in seven patients because of lymphovascular space invasion. During the median follow‐up of 43 months, no recurrences occurred. Twelve women attempted to conceive, and eight of them became pregnant. A total of five children were born, and one baby was full term. Three cases of second trimester, and one case of third trimester preterm births were recorded.ConclusionsFertility was preserved after ART in a moderate number of patients. The pregnancy and birth rates after ART have been improving, and increasing the full‐term birth rate is the next goal. In addition, development of further types of minimally invasive surgery for CCA can be expected.
Effect of medical institution change on gestational duration after the Great East Japan Earthquake: The Fukushima Health Management Survey
Authors: Suzuki Kohta , Goto Aya , Fujimori Keiya 
Published: August 2016

AbstractAimThe aim of this study was to examine the association between medical institution change for perinatal care and gestational duration after the Great East Japan Earthquake using data from the Fukushima Health Management Survey.MethodsThe data of pregnant women who experienced the earthquake in Fukushima prefecture and participated in the Pregnancy and Birth Survey as part of the Fukushima Health Management Survey were analyzed. The primary and secondary outcomes of this study were gestational duration and preterm birth, respectively. The main study factor was prenatal checkup institution (only one institution, changed institution due to self‐referral, changed institution due to medical indication, and went to parents' home for childbirth). Self‐referral was considered as indicative of relocation after the disaster. Multiple linear and logistic regression analyses were conducted to examine the effect of earthquake on each outcome.ResultsA total of 5593 (60.2%) participants experienced the earthquake between the 4th and 37th weeks of their gestational period. After controlling for variables, pregnant women who changed their perinatal checkup institution due to medical indication were significantly associated with shorter gestational duration (β = −10.6, P < 0.001) and preterm birth (adjusted odds ratio, 8.5; 95% confidence interval, 5.8–12.5) compared with women who visited only one institution. Self‐referral, however, was not significantly associated with the outcomes.ConclusionAccording to prenatal checkup status, our results suggest that the effect on gestational duration of the Great East Japan Earthquake and the subsequent Fukushima Daiichi nuclear disaster was not significant.
Successful conservative management of placenta percreta: Investigation by serial magnetic resonance imaging of the clinical course and a literature review
Authors: Sawada Masaaki , Matsuzaki Shinya , Mimura Kazuya , Kumasawa Keiichi , Endo Masayuki , Kimura Tadashi 
Published: August 2016

AbstractPlacenta percreta is a rare condition that presents a risk of massive intraoperative hemorrhage. To decrease maternal morbidity in such cases, conservative management was recently adopted as an option. Nevertheless, severe morbidity occurs in 42% of cases. In addition, the clinical course of conservative management remains unclear. We encountered a case of placenta percreta that was successfully treated by conservative management without complications or other clinical interventions. Serial magnetic resonance imaging (MRI) was performed to investigate the natural course of conservative management of placenta percreta. MRI on postoperative day (POD) 99 showed a decrease in placental size without gadolinium enhancement. MRI on POD 162 showed that the residual placenta was approximately 4 cm in size without gadolinium enhancement. On POD 265, the placenta had almost disappeared. This is the first series of MRI of conservative management of placenta percreta without clinical interventions. We present our case and a literature review.
LAMC2 is a predictive marker for the malignant progression of leukoplakia
Authors: Nguyen Chi Thi Kim , Okamura Takeshi , Morita Kei‐ichi , Yamaguchi Satoshi , Harada Hiroyuki , Miki Yoshio , Izumo Toshiyuki , Kayamori Kou , Yamaguchi Akira , Sakamoto Kei 
Published: August 2016

BackgroundLAMC2 plays an important role in cancer invasion. The aim of this study was to (i) compare the immunoexpression of LAMC2 in different stages of oral squamous cell carcinoma (OSCC), early and advanced, and (ii) to evaluate LAMC2 as a marker of malignant transformation in leukoplakia.Materials and MethodsThe expression of LAMC2 was examined by immunohistochemistry in 50 surgical specimens of advanced OSCC assembled as tissue microarrays, and by cDNA microarray in 43 surgical specimens of advanced OSCC. LAMC2 expression was further examined in 39 surgical specimens of early OSCC and in 93 incisional biopsy specimens of leukoplakia of the tongue, which exhibited epithelial dysplasia. The relationship of LAMC2 expression score with clinico‐pathological characteristics was analyzed.ResultsLAMC2 was remarkably upregulated in OSCC at the cancer–stroma interface. The grade of LAMC2 expression was significantly associated with the pattern and depth of invasion of OSCC. Foci of LAMC2‐positive cells were observed in some cases of leukoplakia. The number and size of LAMC2‐positive foci were significantly associated with the grade of dysplasia. The presence of LAMC2‐positive foci was a significant predictive factor for the malignant progression of leukoplakia. LAMC2‐positive leukoplakia had an approximately 11‐fold increased risk of malignancy compared with LAMC2‐negative leukoplakia.ConclusionsThe results of this study highlight the value of LAMC2 as a marker of cancer invasion. LAMC2‐positive foci in leukoplakia suggest an imminent risk of cancer. LAMC2 immunostaining is expected to contribute to a more precise assessment of the malignancy of leukoplakia.
SPATIAL DISCONTINUITY FOR THE IMPACT ASSESSMENT OF THE EU REGIONAL POLICY: THE CASE OF ITALIAN OBJECTIVE 1 REGIONS*
Authors: Giua Mara 
Published: August 2016

ABSTRACTThe economic impact of the Regional Policy of the European Union is still controversial. This paper exploits administrative boundaries as spatial discontinuity to estimate the causal effect of this policy on the Italian Objective 1 regions’ employment. The analysis, developed both in a border strategy framework (municipalities contiguous to the policy‐change boundary) and with more traditional RDD models balanced by spatial forcing variables (centroids’ distance and coordinates), shows that the EU Regional Policy produced a positive impact on employment levels, without any displacement of economic activities away from nontreated regions and a concentration of the impact in key economic sectors.
Asymmetric Punishment as an Instrument of Corruption Control
Authors: BASU KARNA , BASU KAUSHIK , CORDELLA TITO 
Published: August 2016

AbstractThe control of bribery is a policy objective in many developing countries. It has been argued that asymmetric punishments could reduce bribery by incentivizing whistle‐blowing. This paper investigates the role played by asymmetric punishment in a setting where bribe size is determined by Nash bargaining, detection is costly, and detection rates are set endogenously. First, if whistle‐blowing is infeasible, the symmetry properties of punishment are irrelevant to bribery deterrence but not to bribe size. Bribery disappears if expected penalties are sufficiently high; otherwise, bribe sizes rise as expected penalties rise. Second, when the bribe‐giver may whistle‐blow, a switch from symmetric to asymmetric punishment eliminates bribery only if whistle‐blowing is cheap and the stakes are low. When bribery persists, multiple bribe sizes could survive in equilibrium. The paper derives parameter values under which each of these outcomes occurs, and discusses implications for welfare and the design of policy.
The role of negative and positive memories in fear of dental treatment
Authors: Risløv Staugaard Søren , Jøssing Marit , Krohn Christina 
Published: August 2016

AbstractObjectivesMost young adults transition from childhood dental care to adult dental care without problems. However, a substantial minority leaves childhood dental care with considerable fear of dental treatment. In the present study, we hypothesized that fear of dental treatment in the young adult is influenced by memories of positive and negative childhood experiences with dental care. More specifically, we predicted that the emotional impact, sense of reliving, rehearsal, and belief in the accuracy of a negative treatment memory would be associated with increased dental fear, while positive treatment memories would show the opposite relation.MethodsOne hundred thirty‐six young adults leaving childhood dental care responded to a online measures of dental fear, the most negative and most positive memory of dental treatment, and symptoms of posttraumatic stress disorder.ResultsNegative memories of events that involved pain and dentist behaviors such as impatience or scolding were frequently described and significantly associated with dental fear and symptoms of posttraumatic stress. Positive memories were more frequent, but did not show a consistent relationship with dental fear.ConclusionsThe importance of negative memories suggests an avenue for intervention against dental fear that focuses on restructuring those memories to emphasize positive aspects.
Development of a Semiquantitative Histological Score for the Diagnosis of Heaves Using Endobronchial Biopsy Specimens in Horses
Authors: Bullone M. , Hélie P. , Joubert P. , Lavoie J.‐P. 
Published: August 2016

BackgroundRemodeling of the peripheral airways persists during the asymptomatic phase of heaves. Assessing the histology of large bronchi could facilitate the diagnosis of heaves during remission of the disease.HypothesisAirway inflammation and remodeling in endobronchial biopsy (EBB) specimens differentiate horses with heaves from controls, independently of their clinical status (exacerbation or remission).AnimalsFourteen healthy horses and 24 horses with heaves.MethodsA 14‐point scoring system assessing central bronchial wall inflammation and remodeling was developed. The score was validated by 2 pathologists using specimens obtained from 18 horses (6 controls, 6 with heaves exacerbation, and 6 with heaves remission) in which lung function had been assessed with impulse oscillometry. Clinical and research application of the score was evaluated using biopsy specimens obtained from 20 additional horses (8 controls, 6 with heaves exacerbation, and 6 with heaves remission).ResultsThe score was repeatable (interclass correlation coefficient = 69%). It differentiated horses with heaves in exacerbation (mean ± SD: 6.2 ± 2.2) from those in remission (4.0 ± 1.0) and controls (3.6 ± 1.7, P < 0.0001). The histological scores of horses with heaves correlated with the ratio of respiratory resistance (R) at 5 and 10 Hz (R5 : R10 ratio, r = 0.65, P = 0.03), a parameter assessing airway obstruction.Conclusions and Clinical SignificanceThe proposed histological scoring system correlates with the degree of airway obstruction measured by impulse oscillometry. However, it does not discriminate horses with heaves in remission from controls. Evaluation of EBB specimens might be considered in future research and clinical studies of respiratory diseases in horses.
Seizure Disorders in Goats and Sheep
Authors: Chigerwe M. , Aleman M. 
Published: August 2016

BackgroundGoats and sheep are more likely to be presented for examination for seizures than are cattle, possibly as a consequence of their relatively smaller body size. Currently, no reports describing seizure disorders in goats and sheep are available.ObjectivesTo describe clinical features and treatment outcomes of sheep and goats presented for seizures.AnimalsA total of 59 goats and 21 sheep presented for seizures.MethodsRetrospective study. Medical records from 1994 to 2014 at the Veterinary Medical Teaching Hospital, University of California, Davis, were reviewed. Descriptive statistics were used to summarize data. Logistic regression was performed to determine whether variables were associated with mortality.ResultsThe majority of seizures in goats and sheep had structural or metabolic causes. Polioencephalomalacia (PEM) secondary to ruminal lactic acidosis or PEM of undetermined cause was the most frequently diagnosed cause of seizures in goats and sheep. The proportions of mortality in goats and sheep were 49.2 and 42.9%, respectively. Age increased the odds mortality (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.07, 2.14) in goats. Goats with structural or metabolic causes of seizures had higher odds for mortality (OR, 37.48; 95% CI, 1.12, 99.10) than those with unknown causes. Age and etiological diagnosis were not significant (P> .05) predictors of mortality in affected sheep.Conclusions and Clinical RelevanceSeizure disorders in goats and sheep are associated with high mortality, despite treatment. Current treatment in goats and sheep with seizures warrants further investigation to determine whether treatments are beneficial or detrimental to survival.
Readers building fictional worlds: visual representations, poetry and cognition
Authors: Giovanelli Marcello 
Published: August 2016

AbstractThis article explores the complex nature of the literature classroom by drawing on the cognitive linguistic framework Text World Theory to examine the teacher's role as facilitator and mediator of reading. Specifically, the article looks at how one teacher used visual representations as a way of allowing students to engage in a more personal and less teacher‐driven transaction with a poem and to encourage them to reflect on their own roles as active makers of meaning and knowledge in the classroom. The article shows how teachers can be mindful of the various contextual factors that can privilege and legitimise certain kinds of response in the classroom and be wary of external factors and pressures that can promote the idea of preconceived knowledge. The teacher in the case study presented was able to both facilitate the experience of reading poetry in an unmediated way and also develop her students' metacognition in relation to the reading process itself. The article shows how Text World Theory's status as a socio‐cognitive grammar may be of benefit to teachers in understanding the nature of communicative interaction and literary transaction.
Risks factors for severe pain after selective liver transarterial chemoembolization
Authors: Benzakoun Joseph , Ronot Maxime , Lagadec Matthieu , Allaham Wassim , Garcia Alba Carmela , Sibert Annie , Vilgrain Valérie 
Published: August 2016

AbstractBackground & AimsPost‐procedural pain is frequent after transarterial chemoembolization (TACE) for hepatocellular carcinoma (HCC), and is only partially prevented by treatment selectivity. Our aim was to determine the risk factors of severe pain after selective TACE for HCC.MethodsFrom January 2012 to June 2014, all treatment‐naïve patients undergoing a first selective TACE were included. Risk factors for severe pain, that is, the need for opioid analgesics (grade II–III), were identified by uni‐ and multivariate analysis. Internal validation of a logistic regression model for prediction of opioid intake was done with bootstrapping.ResultsWe analysed 335 tumours (mean 47 ± 37 mm) in 159 patients (131 men), mean 63.4 years old (20–92). Twenty‐seven patients (17%) requested opioids. In univariate analysis, opioid intake was associated with young age (P=.021), doxorubicin dose received (P=.031), large HCC (P=.038), absence of chronic liver disease (P<.001) and alpha‐foetoprotein levels (P=.03). In multivariate analysis, opioid intake was associated with young age (OR=0.65 per 10 years increment, P=.048), absence of chronic liver disease (OR=31.7, P<.001) and a higher fraction of the doxorubicin dose (OR=1.32 per 10% increment, P=.009). The optimism‐corrected area under the curve of the prediction model for opioid intake using these three factors was 0.751.ConclusionIn patients with HCC treated with TACE, selective procedure does not always prevent from severe pain. Young patients without chronic liver disease may be more susceptible to severe pain.