bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quetiapine use in adults in the community: a population-based study in Alberta, Canada
Authors: Duncan Diane , Cooke Lara , Symonds Chris , Gardner David , Pringsheim Tamara 
Published: March 2016

ObjectiveThe objective of this study was to evaluate trends in prescribing of the second-generation antipsychotic medication quetiapine to adults in the province of Alberta from 2008 to 2013 through examination of dispensed prescriptions, and diagnoses associated with users of quetiapine in 2013.MethodsWe analysed administrative data from Alberta Health; the Alberta Pharmaceutical Information Network (PIN) Dispenses health data set, the Practitioner Payments (Fee-For-Service claims) health data set and the Population Registry health data set. These data sets allowed us to identify discrete quetiapine recipients for each calendar year from 2008 to 2013. To evaluate diagnoses associated with users of quetiapine, we evaluated diagnostic codes used by physicians in billings claims in 2013.ResultsQuetiapine use increased over the 6-year time period studied. In 2008, there were 16 087 unique quetiapine recipients in Alberta (7.2 per 1000). By 2013, there were 35 314 unique quetiapine recipients (13.3 per 1000). Use by women was higher than men at all time points. Depression was most common diagnosis associated with quetiapine recipients, which was present in 56% of users of quetiapine. Other common diagnoses associated with quetiapine use included neurotic disorders, bipolar disorder and sleep disturbances.ConclusionsThe current study of quetiapine use in the province of Alberta provides confirmatory data of the increasing use of quetiapine for the treatment of depression and anxiety disorders. Safe and rational prescribing practices must be encouraged in light of the modest advantages of quetiapine over no treatment as an adjunctive treatment of major depression, and the known harms of this medication.
Can't play, won't play: longitudinal changes in perceived barriers to participation in sports clubs across the child–adolescent transition
Authors: Basterfield Laura , Gardner Lauren , Reilly Jessica K , Pearce Mark S , Parkinson Kathryn N , Adamson Ashley J , Reilly John J , Vella Stewart A 
Published: March 2016

BackgroundParticipation in sports is associated with numerous physical and psychosocial health benefits, however, participation declines with age, and knowledge of perceived barriers to participation in children is lacking. This longitudinal study of children and adolescents aimed to use the ecological model of physical activity to assess changes in barriers to participation in sports clubs to identify age-specific and weight-specific targets for intervention.MethodsLongitudinal study—Perceived barriers to sports participation were collected from a birth cohort, the Gateshead Millennium Study (n>500) at ages 9 and 12 years. The open-ended question ‘Do you find it hard to take part in sports clubs for any reason?’ was completed with free text and analysed using content analysis, and the social–ecological model of physical activity.ResultsBarriers from across the social-ecological model were reported. Barriers at 9 years were predominantly of a physical environmental nature, and required high parental involvement (for transport, money, permission), or were associated with a lack of suitable clubs. At 12 years, perceived barriers were predominantly classed as intrapersonal (‘they're boring’) or social environmental (‘my friends don't go’). Perceived barriers were not associated with weight status.ConclusionsPerceived barriers to sports participation change rapidly in childhood and adolescence. Future interventions aiming to increase sports participation in children and adolescents should target specific age groups, should consider the rapid changes which occur in adolescence, and aim to address prominent barriers from across the socioecological model. Perceived barriers may be unrelated to current weight status, allowing for more inclusive solutions.
Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells
Authors: Godek Kristina M. , Venere Monica , Wu Quilian , Mills Kevin D. , Hickey William F. , Rich Jeremy N. , Compton Duane A. 
Published: March 2016

Abstract
Tumors are dynamic organs that evolve during disease progression with genetic, epigenetic, and environmental differences among tumor cells serving as the foundation for selection and evolution in tumors. Tumor-initiating cells (TIC) that are responsible for tumorigenesis are a source of functional cellular heterogeneity, whereas chromosomal instability (CIN) is a source of karyotypic genetic diversity. However, the extent that CIN contributes to TIC genetic diversity and its relationship to TIC function remains unclear. Here, we demonstrate that glioblastoma TICs display CIN with lagging chromosomes at anaphase and extensive nonclonal chromosome copy-number variations. Elevating the basal chromosome missegregation rate in TICs decreases both proliferation and the stem-like phenotype of TICs in vitro. Consequently, tumor formation is abolished in an orthotopic mouse model. These results demonstrate that TICs generate genetic heterogeneity within tumors, but that TIC function is impaired if the rate of genetic change is elevated above a tolerable threshold.
Significance: Genetic heterogeneity among TICs may produce advantageous karyotypes that lead to therapy resistance and relapse; however, we found that TICs have an upper tolerable limit for CIN. Thus, increasing the chromosome missegregation rate offers a new therapeutic strategy to eliminate TICs from tumors. Cancer Discov; 6(5); 532–45. ©2016 AACR.
This article is highlighted in the In This Issue feature, p. 461
Legislação sustentável: diretrizes para incorporação de conceitos de sustentabilidade no código de edificações de Vitória/ES
Authors: Souza Érika da Cunha Victor 
Published: March 2016

Este artigo pretende examinar os aspectos legais da construção sustentável propondo diretrizes para incorporação de conceitos de sustentabilidade no Código de obras e edificações do município de Vitória-ES. No contexto mundial, a sustentabilidade está em evidência, reforçando a preocupação com o impacto gerado pelo homem ao meio ambiente afetando diretamente a economia, a sociedade e o futuro do planeta, por isso a importância da preservação ambiental e o uso eficiente dos recursos naturais (água, ar, energia, materiais etc.). Nesse sentido o papel da legislação é relevante, pois o objetivo do Código de obras dos municípios é garantir condições mínimas de conforto ambiental na implantação de qualquer edificação a ser construída na cidade. A hipótese é que a legislação precisa ser revisada e o objetivo é adequá-la, inserindo conceitos de sustentabilidade. A metodologia baseia-se em pesquisa bibliográfica aplicada ao tema. Conclui-se que o Poder Público deve contribuir mais efetivamente no cenário de reconstrução das cidades, exercendo seu papel através dos instrumentos legais, de forma mais eficaz e atuante, tanto para construção de novas edificações, quanto na reforma e adaptação das já existentes.
Arquitetura e memória
Authors: Almeida Eneida de 
Published: March 2016

Este texto procura investigar as relações entre o projeto de Arquitetura e o restauro, tendo em vista a diluição da fronteira que distingue essas ações. O estudo detém-se na atuação de dois arquitetos contemporâneos: Lina Bo Bardi(1914-1992) e Aldo Rossi (1931-1997). A análise da produção concreta, aqui representada por uma obra de cada arquiteto – o Sesc Pompéia e o Teatro Del Mondo – baseia-se na possibilidade de refletir sobre o papel da memória na Arquitetura: não apenas a memória presente na materialidade dos edifícios e dos tecidos urbanos, mas também a memória como instrumento ativo no interior dos processos mentais adotados pelos autores dos projetos. Recorrendo aos escritos dos arquitetos, bem como a autores que analisam essas intervenções, busca-se reconstituir o percurso de elaboração do projeto, reconhecendo a estratégia que reinterpreta as experiências do passado com o intuito de superar a tradicional contraposição entre “antigo” e “novo”, entre tutela e inovação.
Exploring Predictive Switching Factors for Mobile Number Portability
Authors: Kaur Gurjeet , Sambyal Ritika 
Published: March 2016

Executive Summary In today’s dynamic and competitive environment, customers have numerous choices to take decision on which products and services to use. In the wireless communications industry, the introduction of mobile number portability (MNP) may induce more and more consumers to switch their network operator, as MNP allows consumers to retain their original telephone number when switching from one carrier to another. This might have significant effect on price competition and market share of network providers ( Shi, Chiang, & Rhee, 2006 ). In this backdrop, the present study examines the effect of MNP on consumers’ switching intentions and also the factors affecting those switching intentions in Indian mobile phone services context. Further, the study investigates the relationship between switching intentions and actual switching (ASW) or actual staying (AST) behaviour of consumers. The main findings of the study are: After MNP implementation, consumers’ switching intentions have not changed, as they appear to be satisfied with the services of their current service provider and with regard to those who have already switched, they switched without MNP. Factors such as service quality, relational quality (i.e., satisfaction, trust, and commitment), price, reputation and image, attitude towards switching, perceived ease of use and usefulness, and switching costs (SCs) significantly affect consumers’ switching intentions. Consumers’ switching intentions predict both ASW and AST behaviour of consumers. However, switching intentions better predict AST than ASW behaviour. This implies that even if consumers have intentions to switch their current operator, they would not actually switch because of SCs involved in terms of time, money, and effort. The authors have suggested initiatives that the service providers as well as the Telecom Regulatory Authority of India (TRAI) need to undertake for proper implementation and acceptance of MNP among consumers.
Pharmacist Involvement in a Community Paramedicine Team
Authors: Crockett Baely M. , Jasiak Karalea D. , Walroth Todd A. , Degenkolb Kerri E. , Stevens Andrew C. , Jung Carolyn M. 
Published: March 2016

Background: Hospital readmissions have recently gained scrutiny by health systems as a result of their high costs of care and potential for financial penalty in hospital reimbursement. Mobile-integrated health and community paramedicine (MIH-CP) programs have expanded to serve patients at high risk of hospital readmission. Pharmacists have also improved clinical outcomes for patients during in-home visits. However, pharmacists working with a MIH-CP program have not been previously described. This project utilized a novel multidisciplinary Community Paramedicine Team (CPT) consisting of a pharmacist, paramedic, and social worker to target patients with heart failure at high risk of readmission to assist with coordination of care and education. Objectives: This article describes the development of the CPT, delineation of CPT member responsibilities, and outcomes from pilot visits. Methods: The CPT visited eligible patients in their homes to provide services. Patients with heart failure who were readmitted within 30 days were eligible for a home visit. Results: A total of 6 patients were seen during the pilot, and 2 additional patients were seen after the pilot. Conclusion: Imbedding a pharmacist into a CPT provides a unique expansion of pharmacy services and a novel approach to address hospital readmissions.
Structures of Time in Medieval Historiography
Authors: Spiegel Gabrielle 
Published: March 2016

Medieval historical texts typically deploy a variety of temporal structures that underlie their literary narratives and generate both modes of emplotment and ideological messages. There are three dominant regimes of temporality that appear in these texts, often present in conjunction with one another: a strict series of events, paratactically presented without causal connection between the events that make up the series temporum; a cyclical view of history, originating ultimately in Greek and Roman historiography; and a far-reaching typological, or as Auerbach called it figural, construction of events in which antecedent events become prophecies of later ones, which represent their fulfillment. In addition, later medieval texts tend to be modeled on genealogical patterns. This article investigates the ways in which these temporal schemes are utilized, where, despite the inherent contradictions among such temporal structures, they nonetheless appear together and collaborate in promoting a particular vision of history in the Middle Ages.
Contact-induced usages of volitional moods in East Caucasian languages
Authors: Dobrushina Nina 
Published: March 2016

Aims and hypothesis: The aim of this article is to introduce a case of syntactic borrowing. I test the hypothesis that the uses of volitional forms (optative, imperative, hortative and jussive) in complement clauses of the verbs of wish and in purpose clauses in East Caucasian languages evolve under the influence of Azerbaijanian. Design/methodology/approach and data and analysis: The data of 13 languages are considered in the paper. To prove that shared features are contact-induced, two control languages are included in the sample. Archi belongs to the same genetic group as the languages that use volitionals in subordinate clauses, but is exposed to Azerbaijanian to a lesser extent. Axaxdərə Akhvakh belongs to another group, but has strong contacts with Azerbaijanian due to recent migration. Findings/conclusions: A survey shows that volitionals are used in subordinate clauses most extensively in those languages whose speakers exhibit a high level of bilingualism in Azerbaijanian, and where the contact has been longer. I assume that there is a hierarchy of borrowability of subordinate constructions involving volitionals. Originality: Although the influence of Turkic languages on the languages of the Caucasus in the domain of syntax has been previously discussed, the usage of volitionals in subordinate clauses has not. Significance/implications: It is acknowledged that social factors play an important role in shaping the linguistic consequences of contact. However, evidence of the correspondence between social factors and structural outcomes of language contact is still very scarce. The relevance of two social factors is shown in this paper: the ratio of bilingual speakers and the duration of contact. Limitations: I advance the hypothesis that connects the borrowability of particular constructions to their typological frequency, but the typology of subordinate uses of volitionals is not well enough investigated to make final conclusions.
Brief Online Mindfulness Training
Authors: Kemper Kathi J. 
Published: March 2016

Background. Online training is feasible, but the impact of brief mindfulness training on health professionals needs to be better understood. Methods. We analyzed data from health professionals and trainees who completed self-reflection exercises embedded in online mindfulness training between May 2014 and September, 2015; their changes in mindfulness were measured using standardized scales. Results. Participants included nurses (34%), physicians (24%), social workers and psychologists (10%), dietitians (8%), and others (25%); 85% were women, and 20% were trainees. The most popular module was Introduction to Mindfulness (n = 161), followed by Mindfulness in Daily Life (n = 146), and Mindful Breathing and Walking (n = 129); most (68%) participants who took 1 module took all 3 modules. There were no differences in participation in any module by gender, trainee status, or profession. Completing modules was associated with small but significant improvements on the Cognitive and Affective Mindfulness Scale–Revised, the Mindful Attention Awareness Scale, and the Five Facet Mindfulness Questionnaire ( P < 0.001 for all). Conclusion. Online training reaches diverse health professionals and is associated with immediate improvements in mindfulness. Additional research is warranted to compare the long-term cost-effectiveness of different doses of online and in-person mindfulness training on clinician burnout and quality of care.
Sparse regression models for unraveling group and individual associations in eQTL mapping
Authors: Cheng Wei , Shi Yu , Zhang Xiang , Wang Wei 
Published: March 2016

AbstractBackgroundAs a promising tool for dissecting the genetic basis of common diseases, expression quantitative trait loci (eQTL) study has attracted increasing research interest. Traditional eQTL methods focus on testing the associations between individual single-nucleotide polymorphisms (SNPs) and gene expression traits. A major drawback of this approach is that it cannot model the joint effect of a set of SNPs on a set of genes, which may correspond to biological pathways.ResultsTo alleviate this limitation, in this paper, we proposegeQTL, a sparse regression method that can detect both group-wise and individual associations between SNPs and expression traits.geQTLcan also correct the effects of potential confounders. Our method employs computationally efficient technique, thus it is able to fulfill large scale studies. Moreover, our method can automatically infer the proper number of group-wise associations. We perform extensive experiments on both simulated datasets and yeast datasets to demonstrate the effectiveness and efficiency of the proposed method. The results show thatgeQTLcan effectively detect both individual and group-wise signals and outperforms the state-of-the-arts by a large margin.ConclusionsThis paper well illustrates that decoupling individual and group-wise associations for association mapping is able to improve eQTL mapping accuracy, and inferring individual and group-wise associations.
caOmicsV: an R package for visualizing multidimensional cancer genomic data
Authors: Zhang Hongen , Meltzer Paul S. , Davis Sean R. 
Published: March 2016

Abstract
Background
Translational genomics research in cancers, e.g., International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), has generated large multidimensional datasets from high-throughput technologies. Data analysis at multidimensional level will greatly benefit clinical applications of genomic information in diagnosis, prognosis and therapeutics of cancers. To help, tools to effectively visualize integrated multidimensional data are important for understanding and describing the relationship between genomic variations and cancers.

Results
We implemented the R package, caOmicsV, to provide methods under R environment to visualize multidimensional cancer genomic data in two layouts: matrix layout and combined biological network and circular layout. Both layouts support to display sample information, gene expression (e.g., RNA and miRNA), DNA methylation, DNA copy number variations, and summarized data. A set of supplemental functions are included in the caOmicsV package to help users in generation of plot data sets from multiple genomic datasets with given gene names and sample names. Default plot methods for both layouts for easy use are also implemented.

Conclusion
caOmicsV package provides an easy and flexible way to visualize integrated multidimensional cancer genomic data under R environment.
‘Trial and error…’, ‘…happy patients' and ‘…an old toy in the cupboard’: a qualitative investigation of factors that influence practitioners in their prescription of foot orthoses
Authors: Williams Anita Ellen , Martinez‐Santos Ana , McAdam Jane , Nester Christopher James 
Published: March 2016

AbstractBackgroundFoot orthoses are used to manage of a plethora of lower limb conditions. However, whilst the theoretical foundations might be relatively consistent, actual practices and therefore the experience of patients is likely to be less so. The factors that affect the prescription decisions that practitioners make about individual patients is unknown and hence the way in which clinical experience interacts with knowledge from training is not understood. Further, other influences on orthotic practice may include the adoption (or not) of technology. Hence the aim of this study was to explore, for the first time, the influences on orthotic practice.MethodsA qualitative approach was adopted utilising two focus groups (16 consenting participants in total; 15 podiatrists and 1 orthotist) in order to collect the data. An opening question “What factors influence your orthotic practice?” was followed with trigger questions, which were used to maintain focus. The dialogue was recorded digitally, transcribed verbatim and a thematic framework was used to analyse the data.ResultsThere were five themes: (i) influences on current practice, (ii) components of current practice, (iii) barriers to technology being used in clinical practice, (iv) how technology could enhance foot orthoses prescription and measurement of outcomes, and (v) how technology could provide information for practitioners and patients. A final global theme was agreed by the researchers and the participants: ‘Current orthotic practice is variable and does not embrace technology as it is perceived as being not fit for purpose in the clinical environment. However, practitioners do have a desire for technology that is usable and enhances patient focussed assessment, the interventions, the clinical outcomes and the patient's engagement throughout these processes'.ConclusionsIn relation to prescribing foot orthoses, practice varies considerably due to multiple influences. Measurement of outcomes from orthotic practice is a priority but there are no current norms for achieving this. There have been attempts by practitioners to integrate technology into their practice, but with largely negative experiences. The process of technology development needs to improve and have a more practice, rather than technology focus.
VisArchive: a time and relevance based visual interface for searching, browsing, and exploring project archives
Authors: Hu Keyun , Staub-French Sheryl , Tory Melanie , Nepal Madhav Prasad 
Published: March 2016

Abstract
Background
Project archives are becoming increasingly large and complex. On construction projects in particular, the increasing amount of information and the increasing complexity of its structure make searching and exploring information in the project archive challenging and time-consuming.

Methods
This research investigates a query-driven approach that represents new forms of contextual information to help users understand the set of documents resulting from queries of construction project archives. Specifically, this research extends query-driven interface research by representing three types of contextual information: (1) the temporal context is represented in the form of a timeline to show when each document was created; (2) the search-relevance context shows exactly which of the entered keywords matched each document; and (3) the usage context shows which project participants have accessed or modified a file.

Results
We implemented and tested these ideas within a prototype query-driven interface we call VisArchive. VisArchive employs a combination of multi-scale and multi-dimensional timelines, color-coded stacked bar charts, additional supporting visual cues and filters to support searching and exploring historical project archives. The timeline-based interface integrates three interactive timelines as focus + context visualizations.

Conclusions
The feasibility of using these visual design principles is tested in two types of project archives: searching construction project archives of an educational building project and tracking of software defects in the Mozilla Thunderbird project. These case studies demonstrate the applicability, usefulness and generality of the design principles implemented.