bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia-reoxygenation Extends the Lifespan of Caenorhabditis elegans via SKN-1- and DAF-16A-Dependent Stress Hormesis
Authors: Siswanto Ferbian Milas , Handayani Maria Dara Novi , Firmasyah Rita Dewi , Manalu Jojor Lamsihar , Pramono Adriyan 
Published: October 2024

Aims:
To study the role of hypoxia-reoxygenation and anoxia-starvation on the lifespan
of C. elegans and elucidate the mechanism at molecular levels.

Background:
Increasing evidence indicates that reactive oxygen species (ROS) act as signaling
molecules that promote health. Hormesis occurs when a moderate stress level induces a beneficial
adaptive response, protecting organisms against subsequent exposure to severe stress. Caenorhabditis
elegans is a widely used model organism to study aging and displays a broad hormetic ability
to couple with stress. To date, only few methods are available to induce stress hormesis in C. elegans.

Objectives:
The objectives of this study were to explore the effects of hypoxia-reoxygenation and
anoxia-starvation on the lifespan of C. elegans, exploring the involvement of ROS and oxidative
stress-related pathways, and examining the hormetic property of H/R.

Methods:
The C. elegans were cultured in hypoxic conditions (1% O2) with OP50 bacteria for 24
h followed by reoxygenation (20% O2) (H/R) or in anoxic conditions (0% O2; 100% N2) without
OP50 bacteria for 24 h followed by reoxygenation (20% O2) and food supplementation (A/S). Survivals
were plotted and estimated for probability with Kaplan-Meier analysis.

Results:
The H/R extended the lifespan of C. elegans, and H/R-pretreated worms showed improved
resistance toward A/S compared to naïve worms. The C. elegans SKN-1 and DAF-16 are
important oxidative stress response factors homologous to mammalian Nrf2 and FOXO3, respectively.
Mutations in SKN-1 and DAF-16 blocked H/R-induced life extension. Next, H/R treatment
in C. elegans activated both SKN-1 and DAF-16, as indicated by the upregulation of putative target
genes of SKN-1 (gcs-1 and gss-1) and DAF-16 (sod-3). Moreover, pre-treatment with antioxidants
(N-acetylcysteine, chlorogenic acid, and sulforaphane) reduced ROS levels and diminished
the lifespan extension effect of H/R, indicating their dependency on ROS.

Conclusion:
These results provide evidence that H/R is beneficial for lifespan and stress resistance
by activating the adaptive cellular response pathway (SKN-1 and DAF-16A) toward oxidative
stress.
New Therapeutic Rargets for Cynodon Dactylon in Atherosclerosis: Attenuation of TMAO Generation and Down-regulation of TLR-4 in Rats
Authors: Pashaie Belal , Hobbenaghi Rahim , Malekinejad Hassan 
Published: October 2024

Purpose:
Atherosclerosis (AS) is a chronic disease with worldwide incidence. The current
study was conducted to highlight the molecular pathogenesis of AS and equal effectiveness of cynodon
dactylon’s ethanolic extract (CDE) on the AS-induced injuries.

Methods:
Atherosclerosis was induced experimentally in healthy male rats with a hypercholesterolemic
diet (HCD) for 24 weeks. The HCD-received animals were either treated with normal saline
or various doses of CDE and/or atorvastatin. After 24 weeks of the treatment period, the effects of
HCD on lipid profile, oxidative/nitrosative stress status, inflammatory enzymes (LDH, ALP and CKMB)
activities, trimethylamine oxide (TMAO) concentration in serum along with the expression of
TLR-4 (qPCR) and CD31 (Immunohistochemistry) in coronary and aorta were analyzed

Results:
CDE was able to reduce the HCD-enhanced cholesterol and triglycerides. The HCDelevated
activities of LDH, ALP and CK-MB were declined by CDE. The antioxidant potency of
CDE was comparable with atorvastatin on HCD-induced oxidative/nitrosative stress. The serum
concentration of TMAO was lowered (1.7-fold) by CDE in a dose-dependent manner, while CD31
expression in the endothelial of coronary arterials and aorta in CDE and atorvastatin-received animals
was remarkably increased. The up-regulated expression of TLR-4 (2.5-fold) at mRNA level
was regulated significantly (p < 0.05) and returned to normal level by CDE treatment.

Conclusion:
Results of the current study indicate that the up-regulation of TLR-4 as a main inflammatory
gene and elevation of TMAO are involved in the pathophysiology of AS. Moreover, the protective
effects of CDE on AS may be attributed to its anti-inflammatory and hypolipidemic properties.
KONFLIK PALESTINA-ISRAEL DALAM PERSPEKTIF TEORI RUANG PUBLIK HABERMAS: RENDAHNYA DEMOKRASI KOMUNIKASI PUBLIK PADA PLATFORM “X”
Authors: Chatlina Chiara Dewi 
Published: October 2024

Memanasnya konflik Palestina-Israel turut membuat pengguna platform X turut serta memberikan pendapatnya atas situasi yang sedang terjadi. Dimana, platform X menjadi ruang yang cukup cepat dalam penyebaran informasi. Penelitian ini bertujuan untuk menganalisis komunikasi publik terkait konflik Palestina-Israel dengan merujuk pada teori ruang publik Habermas, terutama dalam konteks platform "X". Peneliti mengkaji dan menganalisis bagaimana demokrasi komunikasi atau kebebasan berpendapat di platform X mengenai konflik Palestina-Israel dengan cara melakukan pendekatan studi kasus menggunakan metode penelitian kualitatif deskriptif dengan teknik pengumpulan data kajian literatur dan observasi melalui platform X. Penelitian ini dapat menyimpulkan Platform X banyak digunakan dalam aksi menyuarakan pendapat kebenaran dalam konflik Palestina dan Israel konflik yang belakangan ini sedang memanas tidak hanya dimanfaatkan oleh individu tetapi platform X juga digunakan oleh institusi-institusi seperti media massa. Meskipun, ada kebebasan berpendapat untuk menyuarakan kebenaran dari konflik yang terjadi di Palestina dan Israel tetapi platform X membatasi konten konflik Palestina dan Israel.
TITI MENTAWAI: SANGGAHAN TERHADAP TATO MENTAWAI TERTUA DI DUNIA (TITI MENTAWAI: REFUTATION OF THE OLDEST MENTAWAI TATTOOS IN THE WORLD)
Authors: Tulius Juniator 
Published: October 2024

Tato tradisional adalah salah satu tradisi prasejarah yang tidak memiliki catatan yang dapat ditelusuri kapan diciptakannya. Tato Mentawai adalah salah satunya. Namun, ada gagasan yang menyatakan bahwa tato Mentawai tertua di dunia. Asumsi ini menjadi perdebatan di dunia akademik dan tersebar di media-media digital. Sebahagian orang meyakininya asumsi itu sebagai sebuah kebenaran. Bahkan asumsi ini dijadikan sebagai acuan yang sahih dalam membuat sebuah kebijakan publik di Mentawai. Argumen ini telah menuai kontroversi di masyarakat Mentawai. Setelah mengulas sumber-sumber ilmiah yang mendasari munculnya asumsi tato Mentawai tertua di dunia fakta-fakta berbeda ditemukan tentang tato tradisional Mentawai. Berdasarkan fakta-fakta itu disimpulkan adalah bahwa tato traditional Mentawai sebagai yang tertua di dunia tidaklah berdasar. (Traditional tattoos are perceived as a prehistoric tradition because they have no traceable records of when they were invented. Mentawai tattoos are one of them. Nonetheless, an assumption has been made to declare that the Mentawai tattoo is the oldest in the world. This assumption has been debated in academic world and spreaded through digital media. This argument has also sparked controversy in Mentawai society. Most of people believe that this assumption is a truth. Even, this assumption has been used as a valid reference in making particular public policy in Mentawai. After reviewing scientific sources of which the assumption of the oldest Mentawai tattoos in the world is made, different facts were found about traditional Mentawai tattoos. Based on these facts, it can be concluded that traditional Mentawai tattoos as the oldest in the world are unfounded).
SHORT TERM RENTAL ACCOMMODATION (STRA) AND HOME SHARING: DIFFERENT TERMINOLOGIES TO ADDRESS LEGAL REQUIREMENT OF PLANNING PERMISSION
Authors: Chua Abdullah Nuraisyah , Ramly Ramzyzan 
Published: October 2024

One of the debates on permissibility of short-term residential accommodation (STRA) is whether the nature of use of the building has significantly changed, with the operation of such business in the building. This led to the issue of whether planning permission is needed as this is a requirement in event of ‘material change of use’ of building. A home may be built as a one-family dwelling, but when it is converted to STRA use, it may be argued that it loses that character and contributes to unauthorized changes in neighbourhood character by intensifying the use both in terms of the number of people who typically use the property at any given time and by the negative impacts associated with frequent turnover. Basically, the main idea of planning permission is to ensure that there are no irregularities emerging from land use and development by individuals such as traffic jams, pollution, nuisance problems, loss of value or even amenities, floods or effects on the neighbourhood and ensures that the new development is suitable for occupation. This article suggests that one possible way to address the ‘change of character’ issue is by differentiating the types of short-term accommodation businesses based on the number of permitted bedrooms, guests, owner occupancy, number of bedrooms, location, and yearly maximum day-cap.
THE RELATIONSHIP BETWEEN TOURIST EXPERIENCE, PLACE ATTACHMENT, AND POST-VISIT INTENTIONS: AN APPLICATION OF S-O-R PARADIGM IN THE CONTEXT OF HANGZHOU, CHINA
Authors: Fan Bai , Isa Mohd Ismail , Mohamed Badaruddin 
Published: October 2024

A key challenge facing destination practitioners and policymakers is to sustain a competitive advantage and to ensure its destination’s success and prosperity under the impact of globalisation. Evidence suggests that the tourist experience can enhance tourists’ attachment and post-visit intention, which is an essential concept in travel and tourism study, as well as destination positioning. Still, there are limitations in the research concerning the relationship between these three factors. This study investigates the mediating effect of place attachment on the relationship between tourist experience and post-visit intention using Stimulus–Organism–Response (S-O-R) paradigm. The data were gathered from 213 respondents among the West Lake Heritage Site users in Hangzhou, China, using the self-administered questionnaires. According to statistical findings, tourist experience influences post-visit intention both directly and indirectly through the mediating role of place attachment. Drawing from these findings, practical information on design, marketing, and experiences for tourism destinations is offered.
Use of Ovitrap for The Spatial Mapping of Aedes spp. in The Endemic Area of Dengue Fever of Baitussalam District Aceh Besar
Authors: Agustina Elita , Muhajirin Muhajirin , Arif Muhammad Iqbal 
Published: October 2024

The strategy for controlling dengue vector through periodic monitoring is an effective mitigation effort. Periodic monitoring of dengue vectors is generally more often conducted in the larval stage rather than the egg stage. Monitoring Aedes eggs periodically using ovitraps is more effective because it is not restricted by season. The objective of this study is to conduct spatial mapping of Aedes spp. distribution using ovitraps in Baitussalam Subdistrict, Aceh Besar. This study used observational methods and purposive sampling to determine the sample houses for ovitrap placement. A total of 50 houses in 5 gampong/village were observed. Analysis was conducted using the GPS Essentials application and Google Earth Pro software. The results showed that there were 4 gampong with Aedes spp. egg distribution in Baitussalam Subdistrict, Aceh Besar, namely Gampong Blang Krueng, Gampong Baet, Gampong Kajhu, and Gampong Cadek, while in Gampong Lam Ujong, no ovitraps positive for Aedes eggs. Ovitraps are an effective method for mapping Aedes spp. in efforts to control dengue. Keyword: Aedes spp; Dengue fever; ovitrap; spatial mapping.
Spirituality in Islamic Education in The Era of Globalization
Authors: Widodo Heru 
Published: October 2024

The current of globalization has a very significant influence, especially negative influences on humans. Spiritual values â€‹â€‹are further away from humans, even in the present era hedonic lifestyles are more visible than living with good character. Behaviors that are far from spiritual values â€‹â€‹cause moral decadence among students. Family and society as school partners in building moral civilization are paralyzed by the rapid development of modern technology.
The characteristics of modern society appear in the loosening of moral values â€‹â€‹in society and the tendency of people to be oriented towards science and technology. The rapid progress in the field of matter resulted in the emergence of spiritual paralysis. People who achieve success with their technological devices do not approach life happiness, on the contrary, humans are trapped in the web of scientific rationality. The movement of modernity has failed, because it lacks attention to the spiritual and metaphysical dimensions.
Spirituality is the strength of the heart that motivates people to the truth and makes care for the conditions of others. Islamic education has a big role to equip students to maintain spirituality and restore human beings in accordance with the potential of nature that God gave from birth so that noble morals are realized and become human characters in all lines of life. To deal with technological advances in the era of globalization, spirituality education is needed, so that spiritual values â€‹â€‹can answer the challenges of the future.
Recognition of Community Environment: Character Education-Based Student Program
Authors: Anhar Rofik 
Published: October 2024

Education is a big investment for all people, especially for parents. It is important for parents to decide the best educational institutions for their children. They will ask their relatives, neighbors, or even internet. It is almost confirmed that the decisions the parents take for determining a certain school will bring out great expectations for their children, such as being excellent, religious, intelligent, having live skills and many more.
Such great expectations above are indeed supposed to be parentsâ€™ visions, educators and even country. In the formulation of the Law on the National Education System states that the aims of the National Education are at developing learnersâ€™ potentials so that they become persons imbued with human values who are faithful and pious to one and only God; who possess morals and noble character; who are healthy, knowledgeable, competent, creative, independent; and as citizens, are democratic and responsible. The idealism of the National Educationâ€™s aims seems to be a Utopia after arising certain phenomena, like several teenagers who is still in student age involve promiscuity, drug abuse, pornography, gadget addiction and loss of respect for parents. Moreover, many cases of prosecutions to parents because the demand that is not granted.
School that as one of the pillars of educations, besides family and society has the strategic position for resolving the such problems. The requirements of curriculum management, human resources, and characters building-based studentsâ€™ programs urge to be carefully formulated and can be implemented.
The paper describes the studentsâ€™ program in the form of the introduction of society environment (PLM) that is held by Al Irsyad Islamic Senior High School of Purwokerto. While there is a program called Community Service Program (KKN) in higher education, it is likewise the program in this school named Introduction of Society Environment (PLM). The program is attractive because it contains many values related to the characters building reinforcements. At least there are nine characters that can be built through this program, such as religious, tolerance, discipline, hard work, nationalism, loving country, being communicative, social and community care. The activities that carried out in the program are the repair of house and mosque, the clothes and staple foods distribution, the SMAIT teaching, the great recitation and free medical treatment.

Keywords: education, studentsâ€™ program, and characters building
KONDISI OSEANOGRAFI DAN KESESUAIAN LOKASI BUDIDAYA LOBSTER DI PERAIRAN TELUK PIDADA, LAMPUNG
Authors: Hartanto Mochamad Tri , Effendi Irzal , Prartono Tri , Puradiredja Sena Pasha , Lestari Dea Fauzia , Susanti Santi , Salsabila Afviya 
Published: October 2024

Kondisi oseanografi dan pemilihan lokasi adalah faktor penting dalam keberhasilan dan keberlanjutan kegiatan budidaya lobster laut menggunakan sistem keramba jaring apung. Salah satu kendala budidaya lobster adalah belum adanya aturan khusus mengenai kriteria kesesuaian lokasi budidaya. Tujuan dari penelitian ini adalah untuk menentukan kriteria dan lokasi yang sesuai untuk budidaya lobster di sekitar perairan Teluk Pidada. Dasar kriteria yang digunakan adalah kesesuaian kondisi oseanografi dan kualitas air laut terhadap konstruksi keramba jaring apung dan habitat alamiah lobster. Metode analisis spasial menggunakan sistem informasi geografi dengan sistem pembobotan digunakan dalam penentuan lokasi yang sesuai untuk budidaya, yang mencakup kecerahan, kekeruhan, TSS, klorofil-a, DO, nitrat, fosfat, amonia, pH, TOM, dan salinitas. Hasil penelitian menunjukkan bahwa 9 dari 15 parameter memiliki kondisi yang sangat sesuai. Hasil studi analisis kesesuaian wilayah memperlihatkan bahwa 78,8% perairan atau seluas 2.890,8 ha dalam kategori sangat sesuai, kemudian hanya 21,2% perairan atau seluas 755,2 ha yang tergolong sesuai, dan tidak ditemukan kategori tidak sesuai di perairan Teluk Pidada. Hampir sebagian besar wilayah teluk sesuai untuk budidaya lobster, namun sebagian titik berlokasi agak menjauh dari daratan karena tingginya nutrien dan run-off kurang sesuai untuk kegiatan budidaya.
Use of Flexible Retort Pouch as a Packaging Alternative for Three Mexican Ready-to-eat Bean Products
Authors: Sauceda Juan Pedro Campos , Soto Manuel Alejandro Uranga , Gutiérrez Ana Karen Hernández , Rubio Verónica Pérez , Heredia José Basilio , Rangel María Dolores Muy 
Published: October 2024

Objective: This study aimed to design a thermal process for three Mexican bean products packaged on flexible retort pouches and to compare the changes in quality, proximate composition, and antioxidant activity.

Method: Three Mexican bean products: “pork beans” (PB), refried beans (RB), and mixed beans (MB, 50% “pork beans” and 50% refried beans), were packaged in retort pouches and processed in a steam/air retort at temperature 122°C, pressure = 2.6 kg·cm-2, come-up time = 13.5 min and 40 min of process, under overpressure conditions. Additionally, nine samples of each bean product packaged in plastic containers of 500 mL were added from the manufacturer's regular hot-fill processing line to be analyzed as control tests. Parameters of quality in all the products were evaluated.

Research results and discussions: The Fo values were 13.2, 13.5, and 11.3 min for PB, RB, and MB, respectively. The beans thermally processed showed better protein, fiber, total phenolic, and essential minerals than traditional treatment, were viable, and did not need refrigerated storage.

Research implications: The study of thermal processes in heat-resistant pouches in three types of ready-to-eat beans is a healthy and nutritious food alternative.

Originality/Value: This study contributes to the development of sterilized foods safe by adjusting the temperature and process time to a Fo value that guarantees the destruction of Clostridium botulinum, with less impact on the final quality of the processed food.
Theoretical Mediation of Drivers and Practices to Enhance Circular Economy Capabilities in SMES: Overcoming Economic, Technological, Cultural, and Social Barriers
Authors: Molina-Morejón Victor-Manuel , Flores Oscar González , Gurrola Eyran Roberto Díaz 
Published: October 2024

Objective: This study aims to use the theoretical mediation of drivers and practices to support SMEs in developing capabilities related to the circular economy (CE). Through this, it seeks to overcome economic, technological, cultural, and social barriers, generating environmental and financial benefits.

Theoretical Framework: Circular economy (CE) theory highlights the need for multidisciplinary approaches to address barriers. These barriers, including economic, technological, social, and cultural challenges, hinder CE adoption, particularly in SMEs. Overcoming such obstacles requires innovative solutions, collaboration with green suppliers, and advanced recycling technologies. Practices like circular design, eco-efficiency, and education are critical in driving CE capability. Moreover, mediating variables, such as drivers in circularity and sustainability-focused education, facilitate the transition to CE, creating economic opportunities and fostering sustainable development across different industries.

Design/Methodology/Approach: The methodology combines qualitative and quantitative research using PLS-SEM. An analysis of six hypotheses was conducted with questionnaires applied to 280 companies, obtaining 124 responses. This innovative approach demonstrates the impact of theoretical mediation between barriers and circular economy capability (CEC), validating five of the six hypotheses.

Results: The key role of mediation in overcoming barriers to the CE is highlighted. Although the direct relationship between cultural and social barriers and the CEC was not validated, the intervention of the mediator construct allowed validation. Additionally, the predictive model is strengthened with indicators such as Q2 and VAF (Variance Accounted For), showing that SMEs can improve their CE capability by overcoming key barriers.

Research Limitations/Implications: In Mexico, SMEs lack a detailed analysis of their economic impact and face obstacles to adopting CE. The described methodology can be replicated in other contexts to facilitate the transition to a circular economy.

Originality/Value: The novel methodology offers a way to overcome barriers to the circular economy and promote a sustainable organizational culture in SMEs. It can be said that the strategy of this study was to achieve circular economy capability (CEC), with the mediating effect serving as the key tactic.