bluuebunny/crossref_metadata_2025_split huggingface dataset:
Beneficial effects of linoleic acid on cardiometabolic health: an update
Authors: Jackson Kristina H. , Harris William S. , Belury Martha A. , Kris-Etherton Penny M. , Calder Philip C. 
Published: September 2024

AbstractLinoleic acid (LA), as a part of the wider debate about saturated, omega-6 and omega-3 fatty acids (FAs) and health, continues to be at the center of controversy in the world of fatty acid research. A robust evidence base, however, demonstrates that higher intakes and blood levels of LA are associated with improved cardiometabolic health outcomes. LA lowers total and low-density lipoprotein cholesterol when compared with saturated fatty acids and carbohydrates. Using large prospective datasets, higher blood levels of LA were associated with lower risk of coronary heart disease, stroke and incident type-2 diabetes mellitus compared with lower levels, suggesting that, across the range of typical dietary intakes, higher LA is beneficial. Recent trials of LA-rich oils report favorable outcomes in people with common lipid disorders. However, an LA intake that is too high can impair endogenous synthesis of eicosapentaenoic acid (EPA) from alpha-linolenic acid (ALA), but the threshold at which this becomes clinically relevant is not known. In the absence of a significant intake of EPA and docosahexaenoic acid, an ideal dietary ratio of LA and ALA may be theoretically useful as it provides insight into the likely extent of endogenous EPA synthesis from ALA. Updating dietary reference intakes (DRIs) for LA and ALA is needed; however, there are insufficient data to establish RDAs for these fatty acids. The omega-6 (n-6) to omega-3 (n-3) PUFA ratio is not informative and does not shed meaningful insight about the amount of individual fatty acids in each class needed to confer health benefits.
Human papillomavirus type-specific distribution in cervical intraepithelial neoplasia and cancer in The Gambia prior to HPV immunization programme: a baseline for monitoring the quadrivalent vaccine
Authors: Bah Haddy , Ceesay Foday , Leigh Ousman , Bah Haddy Tunkara , Savage Ahmad Tejan , Kimmitt Patrick T. 
Published: September 2024

Abstract
Background
Cervical cancer is the leading cause of cancer deaths in Gambian women. Current estimates indicate that 286 women are annually diagnosed with cervical cancer with a fatality rate of 70%. In an attempt to address this, in 2019 the quadrivalent HPV vaccine was incorporated into the Gambia’s Expanded Programme on Immunisation. The study aims to retrospectively assess the prevalence and distribution of high-risk HPV genotype in archived, formalin fixed paraffin embedded cervical biopsy tissues diagnosed with cervical cancer in the Gambia from year 2013–2022.

Method
A total of 223 samples with histologically diagnosis of cervical cancer with adequate tissues were sectioned and deparaffinised, followed by HPV DNA extraction and the detection of HR-HPV by real-time multiplex PCR. The human β-globin gene was amplified in 119 samples, which were subsequently tested for HPV DNA.

Results
HPV was prevalent in 87.4% (104 of 119) cervical cancer cases, 12.6% (15/119) samples tested negative. Amongst cervical cancer cases, HPV 16 genotype was the most frequent type accounting for 53.8% (56 /104), followed by other HR-HPV genotypes 17.3% (18/104), and HPV genotype 18 was 15.4% (16/104). Furthermore, multiple HPV infections involving HPV 16 and /or 18 was detected in 14 cases as follows: HPV genotypes 16 and 18 (3.8%, 4 /104), HPV 16 and other HR-HPV (6.7%, 8/104), and HPV 18 and other HR-HPV (1.9%, 2/104). A significant association between age and diagnosis with cervical cancer (p = 0.02), and HPV genotype 16 (p = 0.04) was observed.

Conclusion
There was no difference in the distribution of HPV 16 and 18 genotypes in cervical cancer cases in The Gambia in comparison with the global distribution. However, the high prevalence of cervical cancer cases with other HR-HPV, and combined infections of HPV 16 with other HR-HPV genotypes seen in this study, clearly shows that the nonavalent HPV vaccine could be more beneficial for The Gambia. This study provides The Gambia with a baseline data to use in policy decisions regarding future evaluation of the quadrivalent HPV vaccine in the country.
An intervention study of poly-victimization among rural left-behind children based on the theoretical framework of planned behavior
Authors: Luo Yandong , Zhou Jiajun , Wen Pan , Chang Ping , Cao Zicheng , Li Liping 
Published: September 2024

Abstract
Background
Poly-victimization (PV) not only threatens physical and mental health but also causes a range of social problems. Left-behind children in rural areas are more likely to experience PV problems. However, there have been fewer studies on PV among rural children, and even fewer intervention studies.

Objective
The difference-in-differences method was employed to analyze the impact of intervention measures, based on the theory of planned behavior, on PV among left-behind children in rural areas.

Methods
The study subjects were left-behind children from six middle schools in two cities in southern China, who completed the baseline survey from 2020 to 2021. They were divided into a control group and an intervention group, each consisting of 228 cases, based on their schools. Before and after the intervention, the Self-made victimization-related knowledge, attitude, and practice questionnaire, Poly-victimization scale, and Middle school students’ coping style scale were used to evaluate the victimization-related KAP(knowledge, attitude, and practice), victimization occurrence, and coping styles of left-behind children, respectively. Stata 15.0 was used to establish a difference-in-differences regression model to analyze the impact of the intervention measures on poly-victimization and coping styles.

Results
Mixed Anova revealed that after the intervention, the KAP scores of the intervention group were significantly higher than those of the control group (p < 0.05). After the intervention, the incidence of child victimization in the intervention group dropped to 9.60% (n = 22), lower than in the baseline survey, with a statistically significant difference (p < 0.01). The incidence of PV among children in the intervention group was lower than that in the control group, with the difference being statistically significant (p < 0.01). The net reduction in the incidence of PV among children was 21.20%. After the intervention, the protection rate for preventing PV among children was 73.33%, and the effect index was 3.75. The intervention improved children’s coping styles, problem-solving, and help-seeking, while reducing negative coping styles such as avoidance and venting, with the differences being statistically significant (p < 0.05).

Conclusion
Intervention measures based on the theory of planned behavior reduce the occurrence of PV among left-behind children, and the intervention effects on different types of victimization are also different.
Perceptions of lifestyle-related risk communication in patients with breast and colorectal cancer: a qualitative interview study in Sweden
Authors: Grauman Åsa , Sundell Erica , Johansson Jennifer Viberg , Cavalli-Björkman Nina , Fahlquist Jessica Nihlén , Hedström Mariann 
Published: September 2024

Abstract
Background
Informing individuals about their risk of cancer can sometimes have negative consequences, such as inflicting unnecessary worry and fostering stigma. This study aims to explore how patients diagnosed with breast or colorectal cancer perceive and experience risk communication, particularly concerning the increased focus on lifestyle behaviors as the cause of cancer.

Methods
Semi-structured interviews were conducted during autumn 2023, with 23 Swedish individuals, aged 34 to 79 years, diagnosed with breast or colorectal cancer. The collected data were analyzed using inductive thematic analysis described by Braun & Clark. The study adopted an experiential orientation grounded in critical realism.

Results
Five themes with ten sub-themes were identified: Thoughts and feelings about the causes of cancer, Moralizing messages and negative encounters, The need to take action, Balancing uncertain risks and a fulfilling life, and Societal benefits of risk communication. The participants expressed that knowledge of the the cause of cancer is closely related to the possibility of taking preventive action against relapses. Ability to take action was also perceived important for their well-being. Therefore, risk information entails both feelings of self-blame and hope for the future. Participants asked for both information and lifestyle support from healthcare professionals. Lifestyle interventions and patient support groups were solicited and perceived as an important aspect of cancer survivals’ well-being, and may help to reduce the cancer-related stigma.

Conclusion
Individuals that have or have had breast or colorectal cancer, including those leading healthy lifestyles, found moralistic risk information offensive, leading to feelings of shame when thinking about other peoples thoughts. Balancing information involves providing transparent, evidence-based information while considering individual and social contexts, avoiding stigmatization and blame, and supplementing information with support.
Proposal of a Creep-Experiment Method and Superficial Creep Coefficient Model of CFT Considering a Stress-Redistribution Effect
Authors: Kim Yu-A. , Lee Jung-Soo , Kwon Seung-Hee , Kim Jin-Kook 
Published: September 2024

AbstractExisting concrete creep coefficient prediction models have the limitation of not considering the structural characteristics of CFT. For this reason, these models tend to overestimate the creep deformation of CFT. Therefore, in order to overcome the limitations of existing CFT creep experiments, this study proposes a creep-experiment method involving the use of CFT that passively changes the load applied to a single concrete specimen by calculating the stress redistribution between the concrete and a steel tube in CFT based on a step-by-step method. Furthermore, by actually applying the proposed experimental method, a creep experiment of CFT lasting for approximately 163 days was performed and a superficial creep coefficient model of CFT was proposed based on long-term strain data from the experiment. In order to verify the proposed superficial creep coefficient model, it was compared with two design criteria (CEB-FIP and ACI) based on the experimental results of this study and references. As a result, compared to the existing design criteria, the value predicted by the proposed superficial creep coefficient model showed good agreement with the experimental results of this study and the references, proving that the proposed creep-experiment method of CFT and superficial creep coefficient model are reasonable.
Digital improvements in the design and construction process of classical Chinese garden rockeries: a study based on material digitization
Authors: Wang Zhe , Song Penghao , Zhang Qingping , Wei Tianheng , Pan Ben 
Published: September 2024

Abstract
Rockeries have a complex and significant role in classical Chinese garden designs. They present distinct artistic characteristics and spatial hierarchies and are crucial to garden heritage conservation. Craftsmanship in rockery construction is a significant part of China’s intangible cultural heritage. Rockeries are primarily composed of naturally occurring rocks chosen for their uniqueness and complex shapes and textures. These rocks present challenges as nonstandard elements within the traditional Chinese garden context, as it is not easy to depict them using conventional blueprints and models. This complicates the design, adjustment, display, and construction of rockeries, which lacks tangible bases for reference. Consequently, the preservation and restoration of garden rockeries is difficult, and the perpetuation and dissemination of rockery construction skills face numerous challenges. This study introduces a method that combines laser scanning and photographic measurements to digitize precisely nonstandard elements of rockery stones. This approach presents an innovative design and construction workflow for rockeries by refining design processes, showcasing real effects, and resolving assembly issues. The results demonstrate that the combination of three-dimensional laser scanning and close-range photogrammetry can accurately replicate the complex forms and textures of these nonstandard elements. The stone coding and digital management system devised based on the logic of construction effectively satisfies the design and building requirements of rockeries. Correspondingly, the proposed digital construction workflow enhances the accuracy of rockery design, presentation, and evaluation, thereby contributing to the protection and restoration of rockery heritage sites and the transmission of rockery construction techniques.
Analysis of the seismic isolation characteristics of the overall friction pendulum bearing (OFPB) of a pagoda under three types of seismic actions
Authors: He Qing , Liu Dewen , Lei Min , Li Xiaopeng , Wu Haoxuan 
Published: September 2024

Abstract
In this study, the seismic performance of an ancient pagoda with significant historical and cultural values in China is upgraded by using overall friction pendulum bearing (OFPB) seismic isolation technology, This technique can be used to isolate the pagoda without damaging it. By implementing the OFPB seismic isolation retrofit on the pagoda and comparing and analyzing it with the unretrofitted seismic model, the response of the pagoda under the action of nine seismic waves of three types, namely, near-field earthquakes, far-field earthquakes, and common earthquakes, is investigated. The results show that the OFPB seismic isolation technique significantly reduces the seismic response of the ghats, in which the acceleration amplification factor is reduced by a maximum of 82.46%, the inter-story displacement is reduced by a maximum of 85.15%, and the base shear force is reduced by a maximum of 96.76%. In addition, the tensile damage of the ghats with OFPB seismic isolation was significantly controlled. While the model without seismic isolation has serious damage under the same seismic action and even faces the risk of collapse. The results of the study confirm that the OFPB seismic isolation technology plays a key role in improving the seismic performance of the tower, which is of great theoretical and practical significance to the protection of the tower, and provides an effective technical way for the protection of the tower in the seismic-prone areas.
Potentilla fulgens Wall. Ex sims. Upregulates insulin receptor substrate 1 and Akt in alloxan-induced diabetic mice
Authors: Sunn Shelareen Ediemi , Pakyntein Careen Liza , Thabah Daiahun , Kharshiing Cynthia Erica , Banerjee Sagnik , Rai Anita Kumari , Bhattacharjee Atanu , Syiem Donkupar 
Published: September 2024

Abstract
Background
Potentilla fulgens Wall. ex Sims. is a medicinal plant used by the locals of Meghalaya. However, its mechanism of action has not been well elucidated. Hence, this study investigated the effect of P. fulgens on IRS1 and Akt. The interaction of the various polyphenols present in P. fulgens with the IR tyrosine kinase and IRS1 PTB domain was studied using auto dock. Changes in expression of antioxidant enzymes, IRS-1, Akt and behavior of normal, diabetic, and diabetic mice treated mice were assessed after 14 days of treatment. Morphological changes in the liver tissue were determined by Transmission Electron Microscopy.

Results
The effect of P. fulgens on blood glucose was time and dose dependent. Treatment with P. fulgens, Cat, E, CE, CEP and metformin improved the activity of catalase, glutathione peroxidase, glycogen, IRS-1 and Akt. The Forced Swimming test showed an altered behavior in diabetic mice. The altered mobility was reverted back to near normal on treatment with P.fulgens, Cat, E, CE, CEP and metformin. The morphological aberrations seen in diabetic animals considerably improved in the treated diabetic group.

Conclusion
P. fulgens and its phytochemicals-catechin and epicatechin are potent sources of antidiabetic drugs, possibly mediating their effects through upregulation of insulin IRS-1 and Akt.
Predictive crypto-asset automated market maker architecture for decentralized finance using deep reinforcement learning
Authors: Lim Tristan 
Published: September 2024

AbstractThis study proposes a quote-driven predictive automated market maker (AMM) platform with on-chain custody and settlement functions, alongside off-chain predictive reinforcement learning capabilities, to improve the liquidity provision of real-world AMMs. The proposed architecture augments Uniswap V3, a cryptocurrency AMM protocol, by using a novel market equilibrium pricing to reduce divergence and slippage losses. Furthermore, the proposed architecture involves a predictive AMM capability, for which a deep hybrid long short-term memory (LSTM) and Q-learning reinforcement learning framework is used. It seeks to improve market efficiency through obtaining more accurate forecasts of liquidity concentration ranges, where liquidity starts moving to expected concentration ranges prior to asset price movement; thus, liquidity utilization is improved. The augmented protocol framework is expected to have practical real-world implications through (1) reducing divergence loss for liquidity providers; (2) reducing slippage for crypto-asset traders; and (3) improving capital efficiency for liquidity provision for the AMM protocol. The proposed architecture is empirically benchmarked against the well-established Uniswap V3 AMM architecture. The preliminary findings indicate that the novel AMM framework offers enhanced capital efficiency, reduced divergence loss, and diminished slippage, which could potentially address several of the challenges inherent to AMMs.
Factors affecting the development of cystoid macular edema following pars plana vitrectomy with silicone oil placement: a retrospective cohort study
Authors: ElSheikh Reem H. , Zhang Sairi , Chauhan Muhammad Z. , Sanders Riley N. , Uwaydat Sami H. 
Published: September 2024

Abstract
Background
Cystoid macular edema (CME) can develop following silicone oil placement in complex vitreoretinal surgeries, contributing to poor visual outcomes. In this study, we investigated the clinical and surgical characteristics associated with the development of CME following the use of silicone oil (SO) in pars plana vitrectomy (PPV) surgeries.

Methods
We conducted a retrospective chart review of patients who underwent implantation of SO during PPV from 2010 to 2020 by a single surgeon. Patient demographics, type of oil, duration of oil tamponade, retinectomy size, diabetic status, lens status, prior panretinal photocoagulation, visual acuity, and incidence of CME were reviewed.

Results
This study included 43 eyes from 40 patients who underwent SO tamponade for retinal detachment (RD) surgery. The mean duration of SO tamponade was 15.7 ± 12.7 months (range: 1–58 months). The most common indication for surgery was diabetic tractional RD (32.7%), followed by traumatic RD (16.3%) and rhegmatogenous RD with proliferative vitreoretinopathy (11.6%). Of the 43 eyes, 18 (41.9%) developed CME for the first time after PPV with SO placement, with 8 (44%) resolving within a year of oil removal. The mean duration for the development of CME was 9 months. A logistic regression model showed that a scleral buckle procedure and poor initial vision were statistically significant factors for predicting the development of CME (ORs: 11.65 and 16.06, respectively). Overall, 91% of the patients had stable or improved vision after surgery.

Conclusions
The use of a scleral buckle procedure and poor initial vision are significant factors for predicting CME following silicone oil tamponade in PPV surgeries, with 41.9% of patients developing CME with an average duration of 9 months. Recognizing such factors can lead to early monitoring and prompt management of CME.

Meeting presentation
Partial analyses were presented at the ASRS 2020 conference.

Clinical trial number
Not applicable.
CRRT circuit venous air chamber design and intra-chamber flow dynamics: a computational fluid dynamics study
Authors: Shimizu Kota , Yamada Toru , Moriyama Kazuhiro , Kato China , Kuriyama Naohide , Hara Yoshitaka , Kawaji Takahiro , Komatsu Satoshi , Morinishi Yohei , Nishida Osamu , Nakamura Tomoyuki 
Published: September 2024

Abstract
Background
Venous air trap chamber designs vary considerably to suit specific continuous renal replacement therapy circuits, with key variables including inflow design and filter presence. Nevertheless, intrachamber flow irregularities do occur and can promote blood coagulation. Therefore, this study employed computational fluid dynamics (CFD) simulations to better understand how venous air trap chamber designs affect flow.

Methods
The flow within a venous air trap chamber was analyzed through numerical calculations based on CFD, utilizing large eddy simulation. The working fluid was a 33% glycerin solution, and the flow rate was set at 150 ml/min. A model of a venous air trap chamber with a volume of 15 ml served as the computational domain. Calculations were performed for four conditions: horizontal inflow with and without a filter, and vertical inflow with and without a filter. Streamline plots and velocity contour plots were generated to visualize the flow.

Results
In the horizontal inflow chamber, irrespective of filter presence, ultimately the working fluid exhibited a downstream vortex flow along the chamber walls, dissipating as it progressed, and being faster near the walls than in the chamber center. In the presence of a filter, the working fluid flowed uniformly toward the outlet, while in the absence of a filter the flow became turbulent before reaching the outlet. These observations indicate a streamlining effect of the filter.
In the vertical inflow chamber, irrespective of filter presence, the working fluid flowed vertically from the inlet into the main flow direction. Part of the working fluid bounced back at the chamber bottom, underwent upward and downward movements, and eventually flowed out through the outlet. Stagnation was observed at the top of the chamber. Without a filter, more working fluid bounced back from the bottom of the chamber.

Conclusions
CFD analysis estimated that the flow in a venous air trap chamber is affected by inflow method and filter presence. The “horizontal inflow chamber with filter” was identified as the design creating a smooth and uninterrupted flow throughout the chamber.
Social media’s traps affecting mental health among young adults
Authors: Abu Shehab A. H. I. , Luca L. , Trifu S. , Udriştoiu I. , Voinescu D. C. , Ciubară A. 
Published: September 2024

Introduction
Due to technological advancements, a growing number of tasks can now be accomplished with the help of a screen. However, there may be repercussions to leading a lifestyle dominated by digital screens. Our study determines an association between problematic social media use and an increase in the incidence of negative mental health outcomes.

Objectives
This paper is a presentation of the mental health issue of young adults related to the use of social media.

Methods
Analysis of user behavior.

Results
The frequency of using these networks, the length of time spent in front of the screens, the way these platforms influence the daily activities of the users, the emotional states felt by them and the possible connection between the use of the Internet and face-to-face communication remain real challenges for mental health specialists.

Conclusions
Preventing the occurrence of mental health disorders among young adults in the context of the development of technology remains a topical issue.

Disclosure of Interest
None Declared