bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Effect of Platelet Mediators to Increase the Skin's Collagen; A Randomized Clinical Trial
Authors: Afarsiabian Hamidollah , Nourbakhsh Mitra , Sadeghizadeh Majid 
Published: July 2017

OBJECTIVE: The aim of this paper is to evaluate the effect of platelet-rich plasma mediators on the reconstruction of facial skin collagen by a platelet cream. Additionally, the cream was composited with plasma and some herbal compounds, which carried those factors through the skin. This method as a non-invasive skin will help the skin rejuvenation.MATERIALS &amp; METHODS: This study is a randomized clinical trial; patients referred to the clinic with positive cases from skin wrinkles along with 20 MHz frequency ultrasound images of their skin faces. All individual enrolled in the study were randomly divided into two groups.Group A 70cc cream including 60cc basic cream (emulsion of Lecithin and Eucerin) in addition of 5cc platelet-rich plasma and 5ccherbal extracted (Herdahelix, Musk and Genestein) to take a month received. Consequently, instructions for use of this cream is that 2.3g of the cream every night to be affected.Group B (controls) received 70cc of the cream involving 6cc basic cream (emulsion of Lecithin and Eucerin) along with 10cc placebo (glycerin) that every night 2.3g of the cream to be applied on the face.After a month increased the amount of facial skin collagen in each group was calculated and compared by ultrasound 20 MHz. In this project compare numerically and in terms of the amount of reflected energy (RE) was performed. In addition, the idea of using plant extracts and platelet mediators to penetrate into the skin was derived from Iranian traditional medicine.FINDINGS: Statistical analysis of the data collection was done by SPSS 18 software. Further, demographic characteristics including age, sex, occupation, socioeconomic status and education level had no effect on the response to treatment (P=0.221), but demographic indicator of age on response to treatment was effective (P=0.021).Respond to the treatment (increase the amount of collagen in the skin) in group A and group B equal to 72.91% and 12.5% respectively. In group A with group B were significant differences in response to treatment, P = 0.000. The only side effect occurred in group A was mild irritation including redness and mild itching, which happened in 2 patients.CONCLUSION: Employee non-invasive method of platelet cream rebuilds collagen in the skin effectively.
Thrombocytopenia and Spontaneous Intracranial Hemorrhage After Olanzapine Therapy
Authors: Cruz Maricel Dela , Danoff Robert 
Published: June 2017

Abstract
The use of atypical antipsychotics in the United States has increased over the past decade, since atypical antipsychotics such as olanzapine and clozapine were introduced. Of the adverse effects associated with olanzapine, bone marrow suppression is one of the most common, but spontaneous intracranial hemorrhage secondary to thrombocytopenia is rare. The present case report describes an 88-year-old man who presented with an intracranial hemorrhage after taking olanzapine for 2 weeks. This case emphasizes the importance of monitoring the potential adverse effects associated with olanzapine and other antipsychotics, especially in elderly patients.
Intercultural Empathy
Authors: Broome Benjamin J. 
Published: June 2017

AbstractEmpathy allows us to step outside the boundaries of our own awareness and imaginatively enter the world of another person. It makes possible meaningful human interaction, and it allows us to engage in tasks that require coordination and consensus. In intercultural situations, empathy is more complex and more difficult, but it is a key competency for effective intercultural communication. In intercultural empathy, understanding is not viewed as a product, but as an ongoing process occurring between communicators. It is created during interaction, emerging as we listen to one another respectfully and engage in a mutual process of exploring and learning together. Intercultural empathy requires shifting our focus away from our own outlooks and toward the experiences of the other, striving for a synthesis of perspectives that allows us to overcome the differences that otherwise separate us from one another.
Cultural Discourse Analysis
Authors: Carbaugh Donal , Cerulli Tovar 
Published: June 2017

Abstract
Cultural discourse analysis (CuDA) is an approach to communication which explores culturally distinctive communication practices as these occur in their everyday contexts, the meanings participants activate in those practices, as well as cross‐cultural analyses of those everyday practices and their meanings. The theory is based upon the premise that communication involves localized means of expression with these means housing a rich process of meaning‐making. That process is investigated through five discursive hubs focused on meanings about identity, action, relations, feeling, and dwelling in nature. The research methodology deriving from the theory includes four distinct yet complementary modes of analysis: descriptive, interpretive, comparative, and critical study. The empirical, field‐based literature has produced insights about intercultural interactions and cultural philosophies of communication around the globe. Particular implications have focused on several concerns, such as identity politics, pedagogical practice, social justice, humanitarian aid, and environmental issues to intercultural dialogue.
Resource intensification and osteoarthritis patterns: changes in activity in the prehistoric Sacramento‐San Joaquin Delta region
Authors: Cheverko Colleen M. , Bartelink Eric J. 
Published: June 2017

AbstractObjectivesEthnohistoric accounts and archaeological research from Central California document a shift from the use of lower‐cost, high‐ranked resources (e.g., large game) toward the greater use of higher‐cost, low‐ranked resources (e.g., acorns and small seeds) during the Late Holocene (4500–200 BP). The subsistence transition from higher consumption of large game toward an increased reliance on acorns was likely associated with increases in levels of logistical mobility and physical activity. This study predicts that mobility and overall workload patterns changed during this transition to accommodate new food procurement strategies and incorporate new dietary resources during the Late Holocene in Central California.Materials and MethodsOsteoarthritis prevalence was scored in the shoulder, elbow, hip, and knee of adult individuals (n = 256) from seven archaeological sites in the Sacramento‐San Joaquin Delta region. Comparisons were made between osteoarthritis prevalence, sex, age‐at‐death, and time period using ANCOVAs.ResultsThe results of this study indicate significant increases in osteoarthritis prevalence in the hip of adult males and females during the Late Period (1200–200 BP), even after correcting for the cumulative effects of age. No differences were observed between the sexes or between time periods for the shoulder, elbow, and knee joints.DiscussionThe temporal increase in hip osteoarthritis supports the hypothesis that there was an increasing need for greater logistical mobility over time to procure key resources away from the village sites. Additionally, the lack of sex differences in osteoarthritis prevalence may suggest that females and males likely performed similar levels of activity during these periods.
Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides
Authors: Corral Maxime G. , Leroux Julie , Tresch Stefan , Newton Trevor , Stubbs Keith A. , Mylne Joshua S. 
Published: June 2017

AbstractHerbicide resistance is driving a need to develop new herbicides. The evolutionary relationship between apicomplexan parasites, such as those causing malaria, and plants is close enough that many antimalarial drugs are herbicidal and so represent novel scaffolds for herbicide development. Using a compound library from the Medicines for Malaria Venture, the model plant Arabidopsis thaliana, and a physicochemical database of known herbicides, a compound was discovered that showed post‐emergence herbicidal activity equal to commercial herbicides. Using structure–activity analysis, important points for its potency were found. The compound was also tested and found to be active against common crop weeds. Physiological profiling suggested the compound was a photosystem II inhibitor, representing a new scaffold for herbicide development. Overall this approach demonstrates the viability of using antimalarial compounds as lead compounds for the development of much needed new herbicides.
An adjustable multi‐scale single beam acoustic tweezers based on ultrahigh frequency ultrasonic transducer
Authors: Chen Xiaoyang , Lam Kwok Ho , Chen Ruimin , Chen Zeyu , Yu Ping , Chen Zhongping , Shung K. Kirk , Zhou Qifa 
Published: June 2017

ABSTRACTThis paper reports the fabrication, characterization, and microparticle manipulation capability of an adjustable multi‐scale single beam acoustic tweezers (SBAT) that is capable of flexibly changing the size of “tweezers” like ordinary metal tweezers with a single‐element ultrahigh frequency (UHF) ultrasonic transducer. The measured resonant frequency of the developed transducer at 526 MHz is the highest frequency of piezoelectric single crystal based ultrasonic transducers ever reported. This focused UHF ultrasonic transducer exhibits a wide bandwidth (95.5% at −10 dB) due to high attenuation of high‐frequency ultrasound wave, which allows the SBAT effectively excite with a wide range of excitation frequency from 150 to 400 MHz by using the “piezoelectric actuator” model. Through controlling the excitation frequency, the wavelength of ultrasound emitted from the SBAT can be changed to selectively manipulate a single microparticle of different sizes (3–100 μm) by using only one transducer. This concept of flexibly changing “tweezers” size is firstly introduced into the study of SBAT. At the same time, it was found that this incident ultrasound wavelength play an important role in lateral trapping and manipulation for microparticle of different sizes. Biotechnol. Bioeng. 2017;114: 2637–2647. © 2017 Wiley Periodicals, Inc.
Cortical thickness and subcortical structure volume abnormalities in patients with major depression with and without anxious symptoms
Authors: Zhao Ke , Liu Haiyan , Yan Rui , Hua Lingling , Chen Yu , Shi Jiabo , Lu Qing , Yao Zhijian 
Published: June 2017

AbstractBackgroundAnxious depression is one of the common subtypes of major depressive disorder (MDD). Clinically, patients with anxious depression exhibit more severe depressive symptoms than patients with nonanxious depression. The aim of the present study was to explore the common and differing cortical and subcortical structural changes between patients with anxious and nonanxious depression.MethodsPatients were placed into one of three groups: the anxious depression group (MDDpatients with high levels of anxiety symptoms,n = 23), the nonanxious depression group (n = 22), and healthy controls (n = 43) that were matched for age, sex, and education level. All participants underwent T1‐weightedMRI. The Freesurfer, which uses a set of automated sequences to analyze the abnormal changes of cortical thickness, cortical and subcortical structures, was used to process the T1 images.ResultsCompared to controls,MDDpatients showed thinner cortical thickness in the left inferior temporal, the right superior temporal, and the right parsorbitalis, and a smaller volume of the left hippocampus. Compared to nonanxious depression, anxious depressive patients showed a cortical thinning of the left superior frontal and right superior temporal, as well as the right lingual, and significantly increased subcortical volume of the bilateral caudate nuclei. Correlation analysis showed that the volumes of the bilateral caudate nuclei were directly proportional to the anxiety/somatization factor score.ConclusionsThese findings suggest that smaller hippocampal volume and atrophic prefrontal and temporal cortices might be a common pattern of cortical and subcortical alterations in patients with depression and/or anxiety. However, the change in the caudate nucleus volume may be indicative of anxious depression and may potentially be used to distinguish anxious from nonanxious depression.
miR‐497 accelerates oxidized low‐density lipoprotein‐induced lipid accumulation in macrophages by repressing the expression of apelin
Authors: Cui Junfeng , Ren Zhong , Zou Wenshuang , Jiang Yanling 
Published: June 2017

AbstractmicroRNAs (miRNAs) play important roles in the pathogenesis of atherosclerosis. A previous study has reported that miR‐497 is elevated in advanced atherosclerotic lesions in an apoE‐deficient (apoE‐/‐) mouse model. The purpose of this study is to test whether miR‐497 can modulate macrophage foam cell formation, an initiating event in atherosclerosis. We found that miR‐497 was upregulated in THP‐1 macrophages after treatment with oxidized low‐density lipoprotein (oxLDL). Enforced expression of miR‐497 promoted lipid accumulation and decreased cholesterol efflux in oxLDL‐exposed THP‐1 macrophages. In contrast, downregulation of miR‐497 suppressed oxLDL‐induced lipid accumulation in THP‐1 macrophages. Apelin was identified to be a downstream target of miR‐497. Overexpression of miR‐497 significantly reduced the expression of apelin in THP‐1 macrophages. Interestingly, delivery of a miR‐497‐resistant variant of apelin significantly inhibited lipid accumulation and enhanced cholesterol efflux in miR‐497‐overexpressing THP‐1 macrophages in response to oxLDL. In addition, miR‐497 expression was increased and negatively correlated with apelin protein expression in human atherosclerotic lesions. In conclusion, miR‐497 contributes to oxLDL‐induced lipid deposition in macrophages largely via targeting of apelin and thus represents a potential therapeutic target for atherosclerosis.
Novel Alkoxy‐Substituted Dipyrrins and Near‐IR BODIPY Dyes—Preparation and Photophysical Properties
Authors: Schoder Stefan , Kord Daoroun Kalai Scheghajeh , Reissig Hans‐Ulrich 
Published: June 2017

AbstractStarting from 3‐alkoxy‐2‐aryl‐substituted pyrroles and aromatic aldehydes, a collection of new dipyrrins was prepared. Under the standard conditions of Treibs, these were converted into the corresponding boron dipyrrins (BODIPYs). Compounds of this type with alkoxy groups at C‐3 position of both pyrrole subunits are new and hence the photophysical properties of this collection of novel dipyrrins and BODIPY dyes were investigated. The dipyrrins show absorption maxima up to 596 nm and emissions of up to 677 nm. For the BODIPY series a remarkable effect of the alkoxy groups was identified, resulting in red shifts for absorptions and emissions. The compound substituted with two 2‐thien‐2‐yl groups and a meso‐C6F5 substituent shows an absorption maximum at 725 nm and emits at 754 nm and thus is a new representative of a near‐IR BODIPY dye related to certain aza‐BODIPYs. Our results demonstrate the influence of the alkoxy groups on the spectroscopic data and reveal the potential of 3‐alkoxy‐2‐aryl‐substituted pyrroles for the design of new fluorophores.
Synthesis of Copper Oxide/Graphite Composite for High‐Performance Rechargeable Battery Anode
Authors: Cho Sanghun , Ahn Yong‐keon , Yin Zhenxing , You Duck‐Jae , Kim Hyunjin , Piao Yuanzhe , Yoo Jeeyoung , Kim Youn Sang 
Published: June 2017

AbstractA novel copper oxide/graphite composite (GCuO) anode with high capacity and long cycle stability is proposed. A simple, one‐step synthesis method is used to prepare the GCuO, through heat treatment of the Cu ion complex and pristine graphite. The gases generated during thermal decomposition of the Cu ion complex (H2 and CO2) induce interlayer expansion of the graphite planes, which assists effective ion intercalation. Copper oxide is formed simultaneously as a high‐capacity anode material through thermal reduction of the Cu ion complex. Material analyses reveal the formation of Cu oxide nanoparticles and the expansion of the gaps between the graphite layers from 0.34 to 0.40 nm, which is enough to alleviate layer stress for reversible ion intercalation for Li or Na batteries. The GCuO cell exhibits excellent Li‐ion battery half‐cell performance, with a capacity of 532 mAh g−1 at 0.2 C (C‐rate) and capacity retention of 83 % after 250 cycles. Moreover, the LiFePO4/GCuO full cell is fabricated to verify the high performance of GCuO in practical applications. This cell has a capacity of 70 mAh g−1 and a coulombic efficiency of 99 %. The GCuO composite is therefore a promising candidate for use as an anode material in advanced Li‐ or Na‐ion batteries.
Synthesis of Ultra‐Small Palladium Nanoparticles Deposited on CdS Nanorods by Pulsed Laser Ablation in Liquid: Role of Metal Nanocrystal Size in the Photocatalytic Hydrogen Production
Authors: Park Hanbit , Reddy D. Amaranatha , Kim Yujin , Lee Seunghee , Ma Rory , Kim Tae Kyu 
Published: June 2017

AbstractIt is imperative to suppress the rate of recombination of photogenerated carriers to improve the semiconductor‐catalyzed solar‐driven production of hydrogen. To this end, photocatalysts comprising active sunlight‐harvesting photo‐absorbers and stable metal co‐catalysts have attracted significant attention. However, the size, clean surface, and highly dispersed nature of the metal co‐catalysts are crucial factors affecting catalyst performance and reaction rate. Nevertheless, most of the available metal nanocrystals have been synthesized by complex procedures using harmful organic templates and stabilizers, affording high‐purity compounds with difficulty and high cost. To overcome these problems, in this study, the pulsed laser ablation in liquid approach was utilized to generate palladium and bimetallic palladium–platinum nanoparticles with an average size and distribution by adjusting the laser wavelength and fluence. A high rate of evolution of hydrogen of 130.33 mmol g−1 h−1 was obtained by using the optimized CdS‐PdPt catalyst under simulated sunlight irradiation. This value is 51.31 times greater than that observed for bare CdS nanostructures. Furthermore, the amount of hydrogen evolved was significantly better than that obtained by using several other noble‐metal co‐catalysts deposited on CdS. This proposed strategy is thought to open new avenues for the design of advanced photocatalytic materials for efficient solar‐driven production of hydrogen.
Incidence of hematologic malignancy and cause‐specific mortality in the Women's Health Initiative randomized controlled trial of calcium and vitamin D supplementation
Authors: Ammann Eric M. , Drake Matthew T. , Haraldsson Bjarni , Wallace Robert B. , Johnson Karen C. , Desai Pinkal , Lin Emily M. , Link Brian K. 
Published: June 2017

BACKGROUNDPrior evidence of a possible link between vitamin D status and hematologic malignancy (HM) in humans comes from observational studies, leaving unresolved the question of whether a true causal relationship exists.METHODSThe authors performed a secondary analysis of data from the Women's Health Initiative Calcium/Vitamin D (CaD) trial, a large randomized controlled trial of CaD supplementation compared with placebo in older women. Kaplan‐Meier and Cox proportional hazards survival analysis methods were used to evaluate the relationship between treatment assignment and 1) incident HM and 2) HM‐specific mortality over 10 years following randomization. HMs were classified by cell type (lymphoid, myeloid, or plasma cell) and analyzed as distinct endpoints in secondary analyses.RESULTSA total of 34,763 Women's Health Initiative CaD trial participants (median age, 63 years) had complete baseline covariate data and were eligible for analysis. Women assigned to CaD supplementation had a significantly lower risk of incident HM (hazard ratio [HR], 0.80; 95% confidence interval [95% CI], 0.65‐0.99) but not HM‐specific mortality (HR, 0.77 [95% CI, 0.53‐1.11] for the entire cohort; and HR, 1.03 [95% CI, 0.70‐1.51] among incident HM cases after diagnosis). In secondary analyses, protective associations were found to be most robust for lymphoid malignancies, with HRs of 0.77 (95% CI, 0.59‐1.01) and 0.46 (95% CI, 0.24‐0.89), respectively, for cancer incidence and mortality in those assigned to CaD supplementation.CONCLUSIONSThe current post hoc analysis of data from a large and well‐executed randomized controlled trial demonstrates a protective association between modest CaD supplementation and HM risk in older women. Additional research concerning the relationship between vitamin D and HM is warranted. Cancer 2017;123:4168–4177. © 2017 American Cancer Society.
RICE CRISPR: Rapidly increased cut ends by an exonuclease Cas9 fusion in zebrafish
Authors: Clements Thomas P. , Tandon Bhavna , Lintel Hendrik A. , McCarty Joseph H. , Wagner Daniel S. 
Published: June 2017

SummaryApplication of CRISPR‐Cas9 technology in diverse organisms has resulted in an explosion of genome modification efforts. To expand the toolbox of applications, we have created an E. coli Exonuclease I (sbcB)–Cas9 fusion that has altered enzymatic activity in zebrafish embryos. This Cas9 variant has increased mutation efficiency and favors longer deletions relative to wild‐type Cas9. We anticipate that this variant will allow for more efficient screening for F0 phenotypes and mutation of a larger spectrum of genomic targets including deletion of regulatory regions and creating loss of function mutations in transcription units with poor sequence conservation such as lncRNAs where larger deletions may be required for loss of function.
Sampling and processing roots from rocky forest soils
Authors: Fahey T. J. , Yanai R. D. , Gonzales K. E. , Lombardi J. A. 
Published: June 2017

AbstractQuantifying root biomass in rocky forest soils is challenging. This report provides practical advice for field sampling and laboratory processing of root biomass in these settings. Manual coring is the most efficient method for sampling fine root biomass in the upper soil profile (we sampled to 30 cm). However, careful correction for coarse fragment volume is needed because manual coring is impeded by rocks. Unbiased estimation of root biomass below obstructions requires either excavating a pit or power coring. We recommend power coring because of the very high field labor costs of pit excavation. Roots can be separated from soil either by dry picking or by wet sieving. For surface organic matter‐rich horizons typical of many forest soils, only dry picking is feasible. A timed interval approach can greatly reduce laboratory processing time. Because sorting live from dead roots is necessarily subjective, efforts to avoid fragmentation of root systems obtained from cores are strongly recommended. Sample size requirements for detecting changes or differences in root biomass at the stand level are presented based on extensive sampling in northern hardwood forests. Detecting 20% differences in fine root (<1 mm) biomass in 0–30 cm soil using ten 5‐cm manual cores generally would require about nine sample plots in a stand, whereas detecting such differences in deep soil (30–50 cm) would be virtually impossible because of extreme spatial variation. Power analyses such as these can help improve experimental designs, as the spatial intensity of sampling determines the detectable difference, which can in turn guide decisions about the temporal frequency of sampling.