bluuebunny/crossref_metadata_2025_split huggingface dataset:
A randomized controlled trial on rehabilitation through caregiver-delivered nurse-organized service programs for disabled stroke patients in rural china (the RECOVER trial): design and rationale
Authors: Yan Lijing L , Chen Shu , Zhou Bo , Zhang Jing , Xie Bin , Luo Rong , Wang Ninghua , Lindley Richard , Zhang Yuhong , Zhao Yi , Li Xian , Liu Xiao , Peoples Nicholas , Bettger Janet Prvu , Anderson Craig , Lamb Sarah E , Wu Yangfeng , Shi Jingpu 
Published: July 2016

Rationale Stroke is the leading cause of death and disability in rural China. For stroke patients residing in resource-limited rural areas, secondary prevention and rehabilitation are largely unavailable, and where present, are far below evidence-based standards. Aim This study aims to develop and implement a simplified stroke rehabilitation program that utilizes nurses and family caregivers for service delivery, and evaluate its feasibility and effectiveness in rural China. Methods and design This 2-year randomized controlled trial is being conducted in 2–3 county hospitals located in northwest, northeast, and southwest China. Eligible and consenting stroke inpatients (200 in total) have been recruited and randomized into either a control or intervention group. Nurses in the county hospital are trained by rehabilitation specialists and in turn train the family caregivers in the intervention group. They also provide telephone follow-up care three times post discharge. The recruitment, baseline, intervention, follow-up care, and evaluation are guided by the RECOVER mobile phone app specifically designed for this study. Study outcome The primary outcome is patients’ Barthel Index (activities of daily living: mobility, self-care, and toileting) at 6 months. Process and economic evaluation will also be conducted. Discussion The results of our study will generate initial high-quality evidence to improve stroke care in resource-scarce settings. If proven effective, this innovative care delivery model has the potential to improve the health and function of stroke patients, relieve caregiver burden, guide policy-making, and advance translational research in the field of stroke care.
Blood pressure burden and outcome in warfarin-related intracerebral hemorrhage
Authors: Schlunk Frieder , Chang Yuchiao , Ayres Alison , Battey Thomas , Vashkevich Anastasia , Raffeld Miriam , Rost Natalia , Viswanathan Anand , Gurol M Edip , Schwab Kristin , Greenberg Steven M , Rosand Jonathan , Goldstein Joshua N 
Published: July 2016

Background and purpose Blood pressure reduction is a promising intervention for acute intracerebral hemorrhage, but clinical trials of this treatment often exclude those with anticoagulant-associated intracerebral hemorrhage, leaving it unclear whether this population might benefit. We examined whether persistently elevated blood pressure values (blood pressure burden) over the first 24 h are associated with hematoma expansion and mortality in anticoagulant-associated intracerebral hemorrhage. Methods We retrospectively identified consecutive patients with primary anticoagulant-associated intracerebral hemorrhage (warfarin anticoagulation) who presented within 6 h after symptom onset and a matched set of non-anticoagulant-associated intracerebral hemorrhage patients. Associations between 24 h blood pressure burden, hematoma expansion, and mortality were evaluated using univariable and multivariable logistic regression. Results Sixty-nine anticoagulant-associated intracerebral hemorrhage and 69 matched non-anticoagulant-associated intracerebral hemorrhage patients were included. Hematoma expansion occurred in 25 anticoagulant-associated intracerebral hemorrhage patients (36%) and 15 control patients (22 %; p = 0.091). Twenty-four-hour blood pressure burden was in fact lower in anticoagulant-associated intracerebral hemorrhage than in non-anticoagulant-associated intracerebral hemorrhage patients (p = 0.033). No association was found in anticoagulant-associated intracerebral hemorrhage and non-anticoagulant-associated intracerebral hemorrhage between BP burden, hematoma expansion, and 30-day mortality. Conclusion We found no evidence that higher 24 h blood pressure burden is associated with hematoma expansion or mortality in anticoagulant-associated intracerebral hemorrhage.
Cell-based laboratory evaluation of coagulation activation by antineoplastic drugs for the treatment of lymphoid tumors
Authors: Tsunaka Misae , Arai Reina , Ohashi Ayaka , Koyama Takatoshi 
Published: July 2016

Objectives: Combining vorinostat, L-asparaginase, and doxorubicin (Dox) led to improved response rates in the treatment of lymphoid tumors. However, deep-vein thrombosis has been noted as one of the most serious side effects with these drugs, and how these regimens cause deep-vein thrombosis is unclear. Methods: We investigated the procoagulant effects of vorinostat, L-asparaginase, and doxorubicin in lymphoid tumors, focusing on tissue factor, phosphatidylserine, and antithrombin. The human vascular endothelial cell line EAhy926 as well as the lymphoid neoplastic cell lines HUT78 (cutaneous T-cell lymphoma), Molt4 (acute T-lymphoblastic leukemia), and Ramos (Burkitt lymphoma) were employed to investigate these procoagulant effects. Results: Vorinostat, L-asparaginase, and doxorubicin induced exposure of phosphatidylserine and procoagulant activity on the surface of lymphoid tumor cells. Vorinostat and doxorubicin also induced phosphatidylserine exposure and increased procoagulant activity on EAhy926 cells. Expression of tissue factor antigen was induced by doxorubicin on the surface of each type of cells, whereas expression of tissue factor mRNA was unchanged. Secretion of antithrombin from HepG2 cells was reduced only by L-asparaginase. Conclusion: These data suggest that vorinostat and doxorubicin may induce procoagulant activity in vessels through apoptosis of tumor cells and through phosphatidylserine exposure and/or tissue factor expression on vascular endothelial cells. L-asparaginase may induce a thrombophilic state by reducing the secretion of anticoagulant proteins such as antithrombin. The laboratory methods described here could be useful to evaluate the procoagulant effects of antineoplastic drugs.
Testicular microlithiasis and preliminary experience of acoustic radiation force impulse imaging
Authors: Pedersen Malene Roland , Osther Palle Jørn Sloth , Rafaelsen Søren Rafael 
Published: July 2016

Background Elastography of the testis can be used as a part of multiparametric examination of the scrotum. Purpose To determine the testicular stiffness using acoustic radiation force impulse imaging (ARFI) technique in men with testicular microlithiasis (TML). Material and Methods In 2013, 12 patients with diagnosed testicular microlithiasis in 2008 (mean age, 51 years; age range, 25–76 years) underwent a 5-year follow-up B-mode ultrasonography with three ARFI elastography measurements of each testis. We used a Siemens Acuson S3000 machine. Results No malignancy was found at the 5-year follow-up B-mode and elastography in 2013. However, we found an increase in TML; in the previous ultrasonography in 2008, eight men had bilateral TML, whereas in 2013, 10 men were diagnosed with bilateral TML. The mean elasticity of testicles with TML was 0.82 m/s (interquartile range [IQR], 0.72–0.88 m/s; range, 65–1.08 m/s). Conclusion Elastography velocity of testis with TML seems to be in the same velocity range as in men with normal testis tissue.
Organophilization of a Brazilian Mg-montmorillonite without prior sodium activation
Authors: Cavalcante Manoella Silva , Paz Simone Patrícia Aranha , Angélica Rômulo Simões , Ito Edson Noryuki , Freitas Neves Roberto 
Published: July 2016

AbstractThe use of Mg-montmorillonite in the production of organoclay without sodium activation was investigated. For this purpose, organophilization experiments were carried out by varying the concentration of two surfactants: hexadecyltrimethylammonium (HDTMA+) and dodecyltrimethylammonium (DTMA+) ions. These surfactantswere used at concentrations 0.7, 1.0 and 1.5 times that of the cation exchange capacity (62.6 meq/100 g) of the clay, with a reaction time of 8 h at temperatures of 25 and 80°C. X-ray diffraction (XRD) results confirmed the intercalation for bothin naturaand activated samples. The Fourier-transforminfrared (FTIR) spectroscopy and XRD results showed that the ratio ofgauche/transconformers decreased with increased basal spacing. The results of thermodifferential and thermogravimetric analysis (DTA/DTG) confirmed the thermal stability of the organoclay up to 200°C, permitting the use of suchmaterial in the synthesis of polymer/clay nanocomposites obtained by the melt blending. Thus, Mg-montmorillonite can be intercalated with alkylammonium ions without prior Na-activation to form organoclays. The possibility of using natural (non-activated) Mg-montmorillonite represents a significant difference in terms of processing cost in comparison with existing Ca-montmorillonite in Brazil or even with imported bentonites that require Na-activation during beneficiation.
Hierarchy for targeting prosurvival BCL2 family proteins in multiple myeloma: pivotal role of MCL1
Authors: Gong Jia-Nan , Khong Tiffany , Segal David , Yao Yuan , Riffkin Chris D. , Garnier Jean-Marc , Khaw Seong Lin , Lessene Guillaume , Spencer Andrew , Herold Marco J. , Roberts Andrew W. , Huang David C. S. 
Published: July 2016

Key Points
Only a minority of myeloma cell lines are killed when the prosurvival BCL2 or BCLXL are selectively inhibited with BH3 mimetic compounds. In contrast, targeting MCL1 readily killed ∼70% of the myeloma cell lines tested, including both low-passage and well-established ones.
Complete genome of Nitrosospira briensis C-128, an ammonia-oxidizing bacterium from agricultural soil
Authors: Rice Marlen C. , Norton Jeanette M. , Valois Frederica , Bollmann Annette , Bottomley Peter J. , Klotz Martin G. , Laanbroek Hendrikus J. , Suwa Yuichi , Stein Lisa Y. , Sayavedra-Soto Luis , Woyke Tanja , Shapiro Nicole , Goodwin Lynne A. , Huntemann Marcel , Clum Alicia , Pillay Manoj , Kyrpides Nikos , Varghese Neha , Mikhailova Natalia , Markowitz Victor , Palaniappan Krishna , Ivanova Natalia , Stamatis Dimitrios , Reddy T. B. K. , Ngan Chew Yee , Daum Chris 
Published: July 2016

AbstractNitrosospira briensisC-128 is an ammonia-oxidizing bacterium isolated from an acid agricultural soil.N. briensisC-128 was sequenced with PacBio RS technologies at the DOE-Joint Genome Institute through their Community Science Program (2010). The high-quality finished genome contains one chromosome of 3.21 Mb and no plasmids. We identified 3073 gene models, 3018 of which are protein coding. The two-way average nucleotide identity between the chromosomes ofNitrosospira multiformisATCC 25196 andNitrosospira briensisC-128 was found to be 77.2 %. Multiple copies of modules encoding chemolithotrophic metabolism were identified in their genomic context. The gene inventory supports chemolithotrophic metabolism with implications for function in soil environments.
Multichannel analysis of passive surface waves based on crosscorrelations
Authors: Cheng Feng , Xia Jianghai , Luo Yinhe , Xu Zongbo , Wang Limin , Shen Chao , Liu Ruofei , Pan Yudi , Mi Binbin , Hu Yue 
Published: July 2016

Passive seismic methods in highly populated urban areas have gained much attention from geophysics and civil engineering communities because traditional seismic surveys, especially in complex urbanized environments, might be improperly applied. In passive seismic methods, directional noise sources will inevitably bring azimuthal effects and spatial aliasing to dispersion measurements due to the fact that true randomness of ambient noise cannot be achieved in reality. To solve these problems, multichannel analysis of passive surface (MAPS) waves based on long noise sequence crosscorrelations is proposed. We have introduced a hybrid method of seismic interferometry and the roadside passive multichannel analysis of surface waves (MASW) using crosscorrelation to produce common virtual source gathers from 1 h multichannel noise records. Common virtual source gathers are then used to do dispersion analysis with an active scheme based on phase-shift measurement. Synthetic tests demonstrated the advantages of this method with azimuthal adjustment and dispersion imaging for directional noise source distribution. Two field applications were conducted, and results from the roadside passive MASW, MAPS, and spatial autocorrelation method were compared. Our study indicated the superiority of MAPS over the roadside passive MASW on the validity of azimuth detection, feasibility of combining the active MASW and MAPS, and accuracy in determining dispersion energy trends, especially at a relative low-frequency range ([Formula: see text]) in urban areas.
Transcutaneous Pco 2 Monitoring in Newborn Infants During General Anesthesia Is Technically Feasible
Authors: Karlsson Victoria , Sporre Bengt , Ågren Johan 
Published: July 2016

BACKGROUND:
Transcutaneous (TC) measurement of Pco
2 (TC Pco
2) is a well-established method to monitor assisted ventilation in neonatal intensive care, but its use in the operating room is limited, and the data regarding its performance during general anesthesia of the newborn are lacking. The aim of this study is to evaluate the performance of continuous TC Pco
2 monitoring during general anesthesia in newborn infants.

METHODS:
Infants (n = 25) with a gestational age of 23 to 41 weeks and a birth weight of 548 to 4114 g were prospectively enrolled. During general anesthesia and surgery, TC Pco
2 was measured continuously and recorded at 1-minute intervals. Five-minute mean values were compared with simultaneously obtained blood gas (BG) analyses of Pco
2. Only the first paired TC and BG samples were used in this analysis. We defined precision as 2.1 times the standard deviation of the difference of the 2 samples. P < .01 was considered statistically significant.

RESULTS:
We obtained samples from 25 infants. The difference between TC and BG was 0.3 ± 0.7 kPa (mean ± standard deviation) giving a precision of 1.47 kPa. Nineteen of twenty-five (76%) sample pairs displayed a difference of <1 kPa (99% confidence interval, 48%–92%, P = .016). The difference in paired samples was similar for different gestational and postnatal ages and did not appear to be affected by electrocautery.

CONCLUSIONS:
In this small study, we did not demonstrate that TC CO2 monitoring was accurate at P < .01. This partly reflects the small size of the study, resulting in wide 99% confidence bounds.
Sex and the Colonial Archive: The Case of “Mariano” Aguilera
Authors: Martínez María Elena 
Published: July 2016

AbstractBuilding on recent scholarship that has problematized the evidentiary status of archived sources and created new methods and analytical categories for reading sex and gender in those sources, this essay considers the case of Mariano Aguilera from mid-eighteenth-century New Spain. Raised as a girl, Aguilera upon reaching adulthood petitioned ecclesiastical authorities to order a physical inspection of his body so that he could be declared a man and marry Clara Ángela López. The essay shows how both abjection and criminality—or a discourse of “queerness”—led Aguilera to be exiled from his community, denied his petition, and prohibited from having any contact with López. The essay opens further questions about the meanings of hermaphroditism and androgyny in the Atlantic world, the ways in which they shaped medical and legal discourses on sodomy in metropolitan and colonial contexts, and the role of doctors and surgeons in legal cases involving queer bodies and lives.
Optimization of Curvilinear Needle Trajectories for Transforamenal Hippocampotomy
Authors: Comber David B. , Pitt E. Bryn , Gilbert Hunter B. , Powelson Matthew W. , Matijevich Emily , Neimat Joseph S. , Webster Robert J. , Barth Eric J. 
Published: July 2016

Abstract

BACKGROUND: The recently developed magnetic resonance imaging–guided laser-induced thermal therapy offers a minimally invasive alternative to craniotomies performed for tumor resection or for amygdalohippocampectomy to control seizure disorders. Current laser-induced thermal therapies rely on linear stereotactic trajectories that mandate twist-drill entry into the skull and potentially long approaches traversing healthy brain. The use of robotically driven, telescoping, curved needles has the potential to reduce procedure invasiveness by tailoring trajectories to the curved shape of the ablated structure and by enabling access through natural orifices.

OBJECTIVE: To investigate the feasibility of using a concentric tube robot to access the hippocampus through the foramen ovale to deliver thermal therapy and thereby provide a percutaneous treatment for epilepsy without drilling the skull.

METHODS: The skull and both hippocampi were segmented from dual computed tomography/magnetic resonance image volumes for 10 patients. For each of the 20 hippocampi, a concentric tube robot was designed and optimized to traverse a trajectory from the foramen ovale to and through the hippocampus from head to tail.

RESULTS: Across all 20 cases, the mean distances (errors) between the hippocampus medial axis and backbone of the needle were 0.55, 1.11, and 1.66 mm for the best, mean, and worst case, respectively.

CONCLUSION: These curvilinear trajectories would provide accurate transforamenal delivery of an ablation probe to typical hippocampus volumes. This strategy has the potential both to decrease the invasiveness of the procedure and to increase the completeness of hippocampal ablation.
Observability Increases the Demand for Commitment Devices
Authors: Exley Christine L. , Naecker Jeffrey K. 
Published: July 2016

Previous research often interprets the choice to restrict one’s future opportunity set as evidence for sophisticated time inconsistency. We propose an additional mechanism that may contribute to the demand for commitment technology: the desire to signal to others. We present a field experiment where participants can choose to give up money if they do not follow through with an action. When commitment choices are made public rather than kept private, we find significantly higher uptake rates. Data are available at http://dx.doi.org/10.1287/mnsc.2016.2501 . This paper was accepted by Uri Gneezy, behavioral economics.
The role of biomarkers in the diagnosis of periprosthetic joint infection
Authors: Shahi AliSina , Parvizi Javad 
Published: July 2016

The role of serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) as the first line for evaluating a patient with periprosthetic joint infection (PJI) has been debunked. We are living in the era of biomarkers for the diagnosis of PJI, and to that effect, several biomarkers have been introduced such as synovial fluid alpha defensin and leukocyte esterase. The synovial fluid leukocyte esterase test has a low cost, is accessible, and has provided promising results for diagnosing PJI. There is an urgent need for an accurate and reliable serum biomarker for diagnosing patients with PJI. Cite this article: Shahi A, Parvizi J. The role of biomarkers in the diagnosis of periprosthetic joint infection. EFORT Open Rev 2016;1:275-278. DOI: 10.1302/2058-5241.1.160019.
Microwave-assisted and conventional synthesis of novel antimicrobial 1,2,4-triazole derivatives containing nalidixic acid skeleton
Authors: Ceylan Sule , Bayrak Hacer , Basoglu Ozdemir Serap , Uygun Yıldız , Mermer Arif , Demirbas Neslihan , Ulker Serdar 
Published: July 2016

Abstract
Carbothioamides 4a,b, obtained from nalidixic acid, were converted to the corresponding 1,3-thiazolidine derivatives 5a,b by cyclocondensation with 2-bromo-1-(4-chlorophenyl)ethanone. Treatment of 4a,b with base afforded 1,2,4-triazoles 6a,b. The synthesis of 1,3-oxazolidine 7 was performed by the reaction of compound 4a with ethyl bromoacetate. Treatment of 4a with acid produced 1,3,4-thiadiazole 8. The reaction of compounds 6a and 6b with several heterocyclic amines in the presence of formaldehyde gave the corresponding Mannich bases 9–15 containing various pharmacophore groups. Conventional and microwave-assisted methods were used for the synthesis. The effect of an acid catalyst on Mannich reactions was investigated. The structures of the newly synthesized compounds were elucidated on the basis of 1H NMR, 13C NMR, FTIR, EIMS techniques, and elemental analysis. All compounds were screened for their antimicrobial activity.
Protection against arsenic-induced hematological and hepatic anomalies by supplementation of vitamin C and vitamin E in adult male rats
Authors: Mondal Rubia , Biswas Sagnik , Chatterjee Anirban , Mishra Raghwendra , Mukhopadhyay Aparna , Bhadra Rupak K. , Mukhopadhyay Prabir Kr. 
Published: July 2016

Abstract

Background:
Chronic arsenic exposure via contaminated drinking water is a global environmental health problem associated with hematological, hepatic and many serious systemic disorders. This study on adult male rats evaluated the protective effects of vitamin E (VE) and vitamin C (VC) against arsenic-mediated hematological and hepatic toxicities.

Methods:
Arsenic was administered orally as arsenic trioxide (3 mg/kg body weight/day), as a single dose for 30 consecutive days or along with VC/ascorbic acid (200 mg/kg body weight/day dissolved in water) and VE/α-tocopherol (400 mg/kg body weight/day dissolved in olive oil) as supplements. Multiple hematological and hepatic parameters were assessed.

Results:
Arsenic exposure caused significant reduction of erythrocyte counts (p<0.05), leukocyte counts (p<0.01) and hemoglobin (Hb) levels (p<0.01). Arsenic exposure also led to marked echinocytic transformation of erythrocytes resulting in increased morphological index (p<0.001). Altered serum oxidative balance was observed with a higher oxidative stress index (p<0.001). The results also showed a significant increase of serum cholesterol (p<0.05), low-density lipoprotein (p<0.001) and triglycerides (p<0.01), and decreased high-density lipoprotein (p<0.01) along with total protein (p<0.01). A marked elevation of hepatic thiobarbituric acid reactive substance (p<0.05) along with decreased reduced glutathione (p<0.001) levels were also observed. Interestingly, co-administration of VC and VE significantly prevented all the arsenic-induced alterations (p<0.05) except Hb content and serum protein.

Conclusions:
The present investigation offers strong evidence regarding the protective efficacy of co-administration of VC and VE against hematotoxicity and hepatotoxicity in adult male rats caused by chronic arsenic exposure.
Beauville structures inp-central quotients
Authors: Gül Şükran 
Published: July 2016

AbstractWe prove a conjecture of Boston that ifp≥5${p\geq 5}$, allp-central quotients of the free group on two generators and of the free product of two cyclic groups of orderpare Beauville groups. In the case of the free product, we also determine Beauville structures inp-central quotients whenp=3${p=3}$. As a consequence, we give an infinite family of Beauville 3-groups, which is different from the ones that were known up to date.
Commensurated subgroups in finitely generated branch groups
Authors: Wesolek Phillip 
Published: July 2016

Abstract
A subgroup

H
≤
G

${H\leq G}$

is commensurated if

|
H
:
H
∩
g
H

g

-
1

|
<
∞

$|H:H\cap gHg^{-1}|<\infty$

for all

g
∈
G

${g\in G}$

. We show that a finitely generated branch group is just infinite if and only if every commensurated subgroup is either finite or of finite index. As a consequence, every commensurated subgroup of the Grigorchuk group and many other branch groups of independent interest is either finite or of finite index.