bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faecal Volatile Organic Compounds to Detect Colorectal Neoplasia in Lynch Syndrome—A Prospective Longitudinal Multicentre Study
Authors: van Liere Elsa L. S. A. , Ramsoekh Dewkoemar , Daulton Emma , Dakkak Maya , van Lingen Joris M. , Stewart Trenton K. , Bosch Sofie , Carvalho Beatriz , Dekker Evelien , Jacobs Maarten A. J. M. , Koornstra Jan Jacob , Kuijvenhoven Johan P. , van Leerdam Monique E. , de Meij Tim G. J. , Meijer Gerrit A. , Spaander Manon C. W. , Covington James A. , de Boer Nanne K. H. 
Published: October 2024

ABSTRACTBackgroundNon‐invasive biomarkers may reduce post‐colonoscopy colorectal cancer (CRC) rates and colonoscopy overuse in Lynch syndrome. Unlike faecal immunochemical test (FIT), faecal volatile organic compounds (VOCs) may accurately detect both advanced and non‐advanced colorectal neoplasia.AimThe aim of this study was to evaluate the potential of faecal VOCs—separately and with FIT—to guide optimal colonoscopy intervals in Lynch syndrome.MethodsProspective longitudinal multicentre study in which individuals with Lynch syndrome collected faeces before and after high‐quality surveillance colonoscopy. VOC‐patterns were analysed using field asymmetric ion mobility spectrometry (FAIMS) and gas chromatography‐ion mobility spectrometry (GC‐IMS) followed by machine learning pipelines, and combined with FIT at 2.55 μg Hb/g faeces. Gas chromatography time‐of‐flight mass spectrometry analysed individual VOC abundance.ResultsAmong 200 included individuals (57% female, median 51 years), 62 had relevant neoplasia at colonoscopy: 3 CRC, 6 advanced adenoma (AA), 3 advanced serrated lesion (ASL), and 50 non‐advanced adenoma (NAA). Respective sensitivity and negative predictive value for CRC and AA (and also ASL in case of FAIMS) were 100% and 100% using FAIMS (54% specificity), and 89% and 99% using GC‐IMS (58% specificity). Respective sensitivity and specificity for any relevant neoplasia were 88% and 44% (FAIMS) and 84% and 28% (GC‐IMS); accuracy did not significantly improve upon VOC‐FIT. VOC‐patterns differed before and after polypectomy (AUC 0.70). NAA showed decreased faecal abundance of butanal, 2‐oxohexane, dimethyldisulphide and dimethyltrisulphide.ConclusionsIn Lynch syndrome, faecal VOCs may be a promising strategy for postponing colonoscopy and for follow‐up after polypectomy. Our results serve as a stepping stone for large validation studies.Trial RegistrationNL8749
When the river meets the sea: Transport and provenance in a long‐lived estuary
Authors: Zametzer Andreas , Dröllner Maximilian , Kirkland Christopher L. , Barham Milo , Walker Alexander T. , Requilme Lloyd 
Published: October 2024

AbstractUnravelling source‐to‐sink relationships of sediment in coastal regions can be particularly challenging due to a variety of transport directions and mixing within varying local environments in response to sea level fluctuations. Post‐glacial sea level rise in the Holocene has resulted in the flooding of former continental margins, locally leading to the separation of islands such as Rottnest in southwest Australia. Rottnest lies approximately 20 km offshore from the mouth of the Swan River, one of the largest permanent river systems across thousands of kilometres of west Australian coastline. In this contribution, we investigate the size, U–Pb age distribution and α‐dose values of detrital zircon grains within 13 sand samples collected from three upstream tributaries that drain the Archean Yilgarn Craton, the Swan River estuary, offshore waters surrounding Rottnest Island and modern beaches. We explore sediment derivation, storage and mixing on this passive margin. Carbonate–silicate sands of the region contain detrital zircon with Archean, Mesoproterozoic and Cambro‐Neoproterozoic age modes, reflecting regional crystalline basement. Eo‐ to Paleoarchean zircon grains, including a previously enigmatic >3500 Ma component, are traced from offshore into the estuary, and specifically the Avon River tributary. Detrital mixing models imply an overall fluvial contribution to the estuary and offshore systems of up to 50–65%. By contrast, modern beach samples are dominated by Swan Coastal Plain recycled sediment of up to 96%. The α‐dose values of the prominent 3300–3150 Ma age component suggest more efficient fluvial discharge in the Paleo‐Swan River than in more recent times. Modern estuary samples have lower average and progressively lower downstream zircon α‐dose values, consistent with prolonged chemical and physical reworking and loss of metamict grains with transport distance in the river. We conclude that fluvial drainage networks distribute a locally persistent catchment signal whilst coastal plains in tectonically quiescent settings appear characterized by sediment reprocessing and mixed provenance.
Non‐linearity and Temporal Variability Are Overlooked Components of Global Vertebrate Population Dynamics
Authors: Boennec Maelys , Dakos Vasilis , Devictor Vincent 
Published: October 2024

ABSTRACTAimPopulation dynamics are usually assessed through linear trend analysis, quantifying their general direction. However, linear trends may hide substantial variations in population dynamics that could reconcile apparent discrepancies when quantifying the extent of the biodiversity crisis. We seek to determine whether the use of non‐linear methods and the quantification of temporal variability can offer a more complete representation of changes in global population dynamics than commonly‐used linear approaches.MethodsWe analysed 6437 population time series from 1257 vertebrate species from the Living Planet Database over the period 1950–2020. We modelled populations through the use of second‐order polynomials and classified trajectories according to their direction and acceleration. We modelled and classified these same populations using a more classical linear trend analysis. We quantified temporal variability using the mean squared error of the fitted polynomials. We then used generalised linear mixed models to test potential sources of heterogeneity in non‐linear trajectories and temporal variability.ResultsIn all, 44.8% of the analysed population time series were non‐linear. Across all populations, 30% were declining, 30% were increasing, and 40% were with no linear trend. Among the population showing no linear trend, half were concave or convex. Non‐linearity was expressed differently between taxonomic groups, with mammals showing higher prevalence of non‐linearity. Marine and freshwater populations were more variable than terrestrial populations, and fish were more variable than other vertebrates. Differences between geographical regions were detected in both non‐linearity and temporal variability, but no straightforward pattern emerged. There were no differences in both components between IUCN categories.Main ConclusionsNon‐linearity and temporal variability reveal usually overlooked dramatic declines or recovery signals in global population dynamics. Thus, moving beyond linearity can improve our understanding of complex population dynamics and better inform conservation decisions. In particular, populations usually classified as ‘stable’ can hide informative changes in non‐linear and variability patterns that need to be considered in global biodiversity assessments.
Commentary on stimulus‐induced arousal with transient electroencephalographic improvement distinguishes nonictal from ictal generalized periodic discharges
Authors: Ng Marcus C. , Zafar Sahar , Foreman Brandon , Kim Jennifer , Struck Aaron F. , Westover M. Brandon 
Published: October 2024

AbstractHere we critique recent arguments proposing to distinguish ictal from non‐ictal generalized periodic discharges (GPDs) based on etiology and stimulation response, arguing that these are unreliable. We advocate for an empirical approach to GPDs: describe objectively, interpret through medication trials, and base further treatment on response. We call for evidence‐based approaches considering meaningful clinical outcomes.
Comparing Genetic Ne Reconstructions Over Time With Long‐Time Wolf Monitoring Data in Two Populations
Authors: Pérez‐Sorribes Laia , Villar‐Yanez Pau , Smeds Linnéa , Mergeay Joachim 
Published: October 2024

ABSTRACTMany methods are now available to calculate Ne, but their performance varies depending on assumptions. Although simulated data are useful to discover certain types of bias, real empirical data supported by detailed known population histories allow us to discern how well methods perform with actual messy and complex data. Here, we focus on two genomic data sets of grey wolf populations for which population size changes of the past 40–120 years are well documented. We use this background to explore in what detail we can retrieve the known population history from these populations, in the light of pitfalls relating to population history, sampling design and the change in the spatial scale at which Ne is estimated as we go further back in time. The Scandinavian wolf population was founded in the early 1980s from a few individuals and has gradually expanded up to 510 wolves. Although the founder event of the Scandinavian population was detected by GONE, the founding effective population size was strongly overestimated when the most recent samples were used, but less so when older samples were considered. Nevertheless, the present‐day Ne corresponds to theoretical expectations. The western Great Lakes wolf population of Minnesota is the only population in the contiguous United States that persisted throughout the 20th century, surviving intense persecution. We found a good concordance between the estimated Ne and trends in census size data, but the reconstruction of Ne clearly highlights the difficulty of interpreting results in spatially structured populations that underwent demographic fluctuations.
Widespread Evidence for Rapid Recent Changes in Global Range and Abundance of Threespine Stickleback (Gasterosteus aculeatus)
Authors: Makhrov Aleksander A. , Houle Easton Y. K. , Hendry Andrew P. , Derry Alison M. , Lajus Dmitry L. 
Published: October 2024

ABSTRACTThe threespine stickleback, Gasterosteus aculeatus, has undergone dramatic increases in abundance in parts of its historical native range, and it is also undergoing a major range expansion. We review available information and discuss the vectors and sources of the species' range expansions, the genetic characteristics of recently founded populations and the ecological consequences of both stickleback introductions and increases in abundance. Dramatic range expansions occurred in the Caspian Sea drainage, large rivers in the Black Sea drainage, reservoirs of the Rhine basin, isolated lakes in North America and Japan and remote islands in the Arctic. Likely reasons for these range expansions include canal construction, accidental inclusion with stocking of commercially valuable fish, intentional release by aquarists and fishermen and climate change. In some cases, range expansions of stickleback were likely facilitated by genetic admixture of previously separated lineages, as well as by high‐standing genetic variation that promotes rapid adaptation to new habitats. Accordingly, range expansions are often accompanied by striking increases in abundance, although these are two distinct processes. Notably, population growth within the species' native range, particularly in the White and Baltic Seas, has been observed alongside expansions into new areas. Where stickleback colonise new habitats or increase in abundance, extensive ecological impacts on ecosystems typically occur. Given these massive and widespread changes, the species has the potential to provide considerable insight into the evolutionary and ecological effects of human impacts on aquatic ecosystems.
Fathers' rejection sensitivity: Links with fathers' and children's social information processing
Authors: Sher‐Censor Efrat , Gur‐Yaish Nurit , Polachek Esther , Ziv Yair 
Published: October 2024

AbstractObjectiveJoining efforts to reveal how fathers affect their children's social competence, we examined whether fathers' rejection sensitivity was associated with biases in their children's social information processing. We also explored whether this link was indirect via biases in fathers' social information processing of their children's peer interactions and, in particular, fathers' behavioral responses.BackgroundChildren's social information processing biases predict their social competence and well‐being. Studies have explored how mothers' rejection sensitivity may impact children's social information processing. Yet, little is known about the role of fathers in this context.MethodParticipants were 85 fathers living in Israel (68.24% Jewish; 31.76% Arab) and their kindergarten children (55.29% female; MChild age in months = 68.70, SD = 5.59). Fathers completed the Adult Rejection Sensitivity Questionnaire and reported their attributions, emotions, and likely behaviors in ambiguous hypothetical scenarios that might suggest a rejection of their child by peers using the Peer Rejection Scenarios measure. Children were interviewed using the Social Information Processing Interview–Preschool Version, tapping hypothetical peer interactions.ResultsFathers' rejection sensitivity was indirectly related to children's generation of maladaptive responses to ambiguous peer interactions through fathers' reports of their more negative emotions and overinvolved behavioral responses.ConclusionResults underscore the role of fathers' rejection sensitivity and emotional and behavioral responses in children's social information processing.ImplicationsThe study points to the need to consider paternal rejection sensitivity in research and interventions focused on promoting children's social competence.
Failure characteristics and stress wave propagation of red sandstone under explosion with varying gas energies
Authors: Zhang Xiang , Chen Jun , Yi Hui , Yang Yang , Fang Shizheng , Li Chengxiao , Chen Shulin , Gao Derui , Wang Zhijie 
Published: October 2024

AbstractThis study designs a blasting loading device capable of changing the utilization of explosive gas by modifying the constraint conditions. The propagation of crack and stress waves in red sandstone under different explosive gases is recorded using digital image correlation technology and ultra‐dynamic strain gauges. Both methods are effectively validated against each other. The results showed that as the utilization of explosive gas increases, the explosive stress wave induces layer cracking at the specimen's far end and tensile failure at its near end. In addition, the larger the stress wave's amplitude, the greater the spatial attenuation coefficients of the compression and tension waves. The study ultimately deduces the propagation process of the incident wave and analyzes the influence of stress wave propagation on the specimen's failure characteristics.
Effect of Heat Treatment on Fatigue Life of Ti‐6Al‐4V Alloy With Two‐Layered Structure of Additively Manufactured and Conventional Wrought Parts
Authors: Koyama Atsuhiro , Sonobe Yohei , Saimoto Akihide , Uematsu Yoshihiko 
Published: October 2024

ABSTRACTTo investigate fatigue life of the two‐layered Ti‐6Al‐4V alloys with additively manufactured layer and conventional wrought layer, fatigue tests were conducted under constant amplitude loading. The effect of post heat treatment on fatigue life was also examined. Three types of specimens were used as test materials: specimens without heat treatment (As‐built material), specimens with solution aging treatment (STA), and specimens with heat treatment (1100AC). Compared at the same stress amplitude, there was a tendency that STA material has a longer fatigue life because of the lower initial stress of STA specimens at the attachment of the fatigue testing machine. However, As‐built material had the longest and 1100AC material had the shortest fatigue lives compared at the same σswt. And a comparison of the fatigue limits showed that As‐built and STA materials have almost the same values.
Unifying Coral Reef States Through Space and Time Reveals a Changing Ecosystem
Authors: Brandl Simon J. , Carlot Jérémy , Stuart‐Smith Rick D. , Keith Sally A. , Graham Nicholas A. J. , Edgar Graham J. , Wicquart Jérémy , Wilson Shaun K. , Karkarey Rucha , Donovan Mary K. , Arias‐Gonzalez Jesus E. , Arthur Rohan , Bigot Lionel , Exton Dan A. , Goetze Jordan , Hoey Andrew S. , Holmes Thomas , Maréchal Jean‐Philippe , Mouillot David , Ross Claire L. , Wickel Julien , Adjeroud Mehdi , Parravicini Valeriano 
Published: October 2024

ABSTRACTAimEcological state shifts that alter the structure and function of entire ecosystems are a concerning consequence of human impact. Yet, when, where and why discrete ecological states emerge remains difficult to predict and monitor, especially in high‐diversity systems. We sought to quantify state shifts and their drivers through space and time in the most ecologically complex marine ecosystem: tropical coral reefs.LocationWorldwide.Time Period1987–2019.Major Taxa StudiedCoral reef communities.MethodsUsing a global dataset of 3375 coral reef surveys, along with 13 time series datasets ranging between 1987 and 2019, we applied a novel double‐dichotomy approach to classify coral reefs into four simplified and discrete states based on the relative contributions of corals versus algae to benthic cover and small‐bodied versus large‐bodied fishes to fish standing stock. We then examined state shifts considering a range of spatial predictors and tested whether states have shifted directionally over time, and the nature of the most common transitions.ResultsWe show that geographic, environmental and anthropogenic context fundamentally shapes coral reef states at the local scale, which explains disparities among case studies, and stakes out critical baseline expectations for regional management efforts. We also reveal clear multi‐decadal state shifts on coral reefs: over time, systems dominated by reef‐building corals and small‐bodied, planktivorous fishes tend to have been replaced with reefs characterised by algae and larger‐bodied fishes.Main ConclusionsOur results suggest a previously unrecognised transition from systems that harness external subsidies through small‐bodied consumers associated with structurally complex live corals, to herbivore‐dominated systems with stronger bottom‐up dynamics. Overall, the partitioning of complex reef ecosystems into a small suite of discrete ecological states suggests that spatial context‐dependency, shifting baselines and changes in reef functioning are crucial considerations for coral reef management in the 21st century.
Navigating Avatar‐Based Marketing From Value Aspects: A Systematic Literature Review and Forward‐Looking Research Agenda
Authors: Rahman Md. Shahinur , Sabbir Md. Mahiuddin , Zhang Jing , Taufique Khan Md. Raziuddin , Rahman Md. Masudur 
Published: October 2024

ABSTRACTVirtual avatar deployment has opened a new window for many industries in service personalization and customization, offering customers “anytime–anywhere” services. It becomes increasingly essential for marketing practitioners and scholars to clearly understand how avatar attributes and traits are reshaping customer value perceptions in the digital world. Despite the exponential growth of research interest within this area in the last decade, the literature on avatar attributes and consumer‐perceived values remains fragmented and isolated. Given this circumstance, this review draws on the theory–context–characteristics–methods framework and explores the extant literature to provide a collective and comprehensive insight into dominant theories, contexts, characteristics, and methodologies in the context of avatar‐based marketing (ABM). A systematic literature review was applied to rigorously review 57 published articles on avatars and ABM from 2005 to 2023. Using in‐depth content analysis, the current review sheds light on the opportunity to extend the theoretical foundations for the ABM literature. It also identifies gaps in understanding avatar attributes and the associated consumer values, with potential implications for consumer behavior. Finally, it sums up a comprehensive future research agenda.
Social Media Influencer Marketing: A Systematic Literature Review Using TCM and ADO Framework
Authors: Pushparaj P. , Kushwaha Bijay Prasad 
Published: October 2024

ABSTRACTSocial media influencers (SMIs) have a significant impact on consumer decisions, and research in this area comprises a substantial portion of the literature. Despite marketing firms' attention to SMIs, a comprehensive evaluation of their impact on the consumer decision literature is lacking. Therefore, this study offers a comprehensive and systematic analysis of the impact of social media influencers on consumer decisions. Using a framework‐based approach, the TCM framework provides a structured exploration of the theories, contexts, and methods found in 106 relevant articles. Concurrently, the ADO framework examines the determinants of consumers' decisions. This review identifies 62 distinct antecedents categorized into seven broad groups and explores why specific factors positively or negatively affect purchase decisions and outcomes. This study highlights key gaps in the current influencer marketing literature and provides insights for future research and practical implications in the fields of psychology, marketing, and consumer behavior.
Treatment outcomes of mild to moderate Clostridioides difficile infection in inflammatory bowel disease: an Australian experience
Authors: Jacob Rachael , Chu Virginia , Ng Watson , Williams Astrid‐Jane , Connor Susan 
Published: October 2024

AbstractBackgroundThe incidence of Clostridioides difficile infection (CDI) in inflammatory bowel disease (IBD) is rising and associated with adverse outcomes. Optimal treatment for CDI in IBD remains unknown, with various organisations suggesting vancomycin as first‐line therapy.AimTo compare treatment outcomes for metronidazole versus vancomycin in mild to moderate CDI in IBD.MethodsA retrospective analysis of IBD patients with CDI between January 2015 and December 2019 was conducted. Laboratory data and clinical outcomes were examined.ResultsForty‐seven discrete episodes of CDI in 34 patients occurred during the study period. Fifty‐three per cent (18) had Crohn's disease, 44% (15) ulcerative colitis and 3% (1) IBD unclassified. Six per cent (3/47) of CDI cases were severe and excluded. In 68% (30/44) of mild to moderate CDI, metronidazole was prescribed, with treatment failure in 20% (6/30), CDI recurrence in 13% (4/30) and 20% (6/30) experiencing a further CDI episode. Comparatively, vancomycin was prescribed in 23% (10/44) without any treatment failures; however, 10% (1/10) had CDI recurrence and 40% (4/10) experienced another CDI episode. No statistically significant difference was noted between metronidazole and vancomycin therapy for treatment failure (P = 0.31), CDI recurrence (P = 1.0) or further CDI episodes (P = 0.23). Proton‐pump inhibitor therapy was the only risk factor associated with a higher rate of the composite outcome and remained significant on multivariate logistic regression (odds ratio 12.99 (95% confidence interval = 1.21–139.97), P = 0.03).ConclusionMetronidazole compared to vancomycin for treatment of mild to moderate CDI in IBD is effective however may be associated with higher rates of treatment failure.