bluuebunny/crossref_metadata_2025_split huggingface dataset:
Von Sensormessungen zu Bodeneigenschaftskarten
Authors: Bönecke Eric , Schröter Ingmar , Vogel Sebastian , Gebbers Robin , Rühlmann Jörg , Meyer Swen 
Published: September 2024

ZusammenfassungEine teilflächenspezifische Kalkung erfordert hochauflösende Bodendaten, um die Variabilität der Bodeneigenschaften besser zu bewerten und die Entscheidungssicherheit zu erhöhen. Verschiedene Bodensensoren können diese Informationen liefern und mittels geeigneter Verfahren können damit Bodeneigenschaftskarten erzeugt werden. Die mit den mobilen Sensoren erfassten Punktmessdaten werden zunächst interpoliert, um flächenhafte Sensordatenkarten zu erhalten. Anschließend werden diese Karten zur Festlegung von Beporbungspunkten verwendet. An diesen Referenzpunkten werden im Feld Proben entnommen und im Labor mit Standardmethoden auf die Bodeneigenschaften untersucht. Die flächenhaften Sensordaten werden am Ende mit den Labordaten verschnitten, um Bodeneigenschaftskarten für pH, Textur und Humusgehalt zu erstellt.
Die pH-BB Toolbox
Authors: Schröter Ingmar , Walch Jakob , Zieger Karin 
Published: September 2024

ZusammenfassungFür die Präzisionslandwirtschaft sind hochaufgelöste Bodeneigenschaftskarten, die die Variabilität im Feld kleinräumig abbilden, von zunehmender Bedeutung. Durch ihre Verknüpfung mit agronomischen Entscheidungsregeln wie z. B. dem VDLUFA-Algorithmus zur Bestimmung des Kalkbedarfs kann die Düngemenge für jeden Ort des Feldes ermittelt werden. Für die Errechnung einer Streukarte aus Sensordaten ist eine Vielzahl statistischer, empirischer, geostatistischer und hybrider Methoden erforderlich. Damit ihre Anwendung in der landwirtschaftlichen Praxis gelingt, müssen sie in Form von Werkzeugen einfach und niedrigschwellig zur Verfügung stehen. Mit der pH-BB Toolbox wurde ein Werkszeug zur Verbesserung des Managements der Bodenacidität in Deutschland entwickelt. Der modulare Aufbau der Toolbox erlaubt Landwirt/-innen den einfachen und schnellen Einstieg in eine teilflächenspezifische Bewirtschaftung. Mit dem Bodenkartenmodul kann die Datenbasis für eine präzise und ressourcenschonende Landwirtschaft geschaffen werden. In diesem Kapitel werden die einzelnen Module der Toolbox kurz vorgestellt und beispielhaft erläutert.
Enhancement of mycobacterial pathogenesis by host interferon-γ
Authors: Hop Huynh Tan , Liao Pao-Chi , Wu Hsin-Yi 
Published: September 2024

AbstractThe cytokine IFNγ is a principal effector of macrophage activation and immune resistance to mycobacterial infection; however, pathogenic mycobacteria are capable of surviving in IFNγ-activated macrophages by largely unknown mechanisms. In this study, we find that pathogenic mycobacteria, including M. bovis BCG and M. tuberculosis can sense IFNγ to promote their proliferative activity and virulence phenotype. Moreover, interaction with the host intracellular environment increases the susceptibility of mycobacteria to IFNγ through upregulating expression of mmpL10, a mycobacterial IFNγ receptor, thereby facilitating IFNγ-dependent survival and growth of mycobacteria in macrophages. Transmission electron microscopy analysis reveals that IFNγ triggers the secretion of extracellular vesicles, an essential virulence strategy of intracellular mycobacteria, while proteomics identifies numerous pivotal IFNγ-induced effectors required for mycobacterial infection in macrophages. Our study suggests that sensing host IFNγ is a crucial virulence mechanism used by pathogenic mycobacteria to survive and proliferate inside macrophages.
Dietary patterns during pregnancy and maternal and birth outcomes in women with type 1 diabetes: the Environmental Determinants of Islet Autoimmunity (ENDIA) study
Authors: Thomson Rebecca L. , Brown James D. , Oakey Helena , Palmer Kirsten , Ashwood Pat , Penno Megan A. S. , McGorm Kelly J. , Battersby Rachel , Colman Peter G. , Craig Maria E. , Davis Elizabeth A. , Huynh Tony , Harrison Leonard C. , Haynes Aveni , Sinnott Richard O. , Vuillermin Peter J. , Wentworth John M. , Soldatos Georgia , Couper Jennifer J. ,   on behalf of the ENDIA Study Group
Published: September 2024

Abstract
Aims/hypothesis
Dietary patterns characterised by high intakes of vegetables may lower the risk of pre-eclampsia and premature birth in the general population. The effect of dietary patterns in women with type 1 diabetes, who have an increased risk of complications in pregnancy, is not known. The aim of this study was to investigate the relationship between dietary patterns and physical activity during pregnancy and maternal complications and birth outcomes in women with type 1 diabetes. We also compared dietary patterns in women with and without type 1 diabetes.

Methods
Diet was assessed in the third trimester using a validated food frequency questionnaire in participants followed prospectively in the multi-centre Environmental Determinants of Islet Autoimmunity (ENDIA) study. Dietary patterns were characterised by principal component analysis. The Pregnancy Physical Activity Questionnaire was completed in each trimester. Data for maternal and birth outcomes were collected prospectively.

Results
Questionnaires were completed by 973 participants during 1124 pregnancies. Women with type 1 diabetes (n=615 pregnancies with dietary data) were more likely to have a ‘fresh food’ dietary pattern than women without type 1 diabetes (OR 1.19, 95% CI 1.07, 1.31; p=0.001). In women with type 1 diabetes, an increase equivalent to a change from quartile 1 to 3 in ‘fresh food’ dietary pattern score was associated with a lower risk of pre-eclampsia (OR 0.37, 95% CI 0.17, 0.78; p=0.01) and premature birth (OR 0.35, 95% CI 0.20, 0.62, p<0.001). These associations were mediated in part by BMI and HbA1c. The ‘processed food’ dietary pattern was associated with an increased birthweight (β coefficient 56.8 g, 95% CI 2.8, 110.8; p=0.04). Physical activity did not relate to outcomes.

Conclusions/interpretation
A dietary pattern higher in fresh foods during pregnancy was associated with sizeable reductions in risk of pre-eclampsia and premature birth in women with type 1 diabetes.

Graphical Abstract
On the modulus of continuity of fractional Orlicz-Sobolev functions
Authors: Alberico Angela , Cianchi Andrea , Pick Luboš , Slavíková Lenka 
Published: September 2024

Abstract
Necessary and sufficient conditions are presented for a fractional Orlicz-Sobolev space on

$${\mathbb {R}}^n$$

R

n

to be continuously embedded into a space of uniformly continuous functions. The optimal modulus of continuity is exhibited whenever these conditions are fulfilled. These results pertain to the supercritical Sobolev regime and complement earlier sharp embeddings into rearrangement-invariant spaces concerning the subcritical setting. Classical embeddings for fractional Sobolev spaces into Hölder spaces are recovered as special instances. Proofs require novel strategies, since customary methods fail to produce optimal conclusions.
Mappings of finite distortion on metric surfaces
Authors: Meier Damaris , Rajala Kai 
Published: September 2024

Abstract
We investigate basic properties of mappings of finite distortion

$$f:X \rightarrow \mathbb {R}^2$$

f
:
X
→

R

2

, where X is any metric surface, i.e., metric space homeomorphic to a planar domain with locally finite 2-dimensional Hausdorff measure. We introduce lower gradients, which complement the upper gradients of Heinonen and Koskela, to study the distortion of non-homeomorphic maps on metric spaces. We extend the Iwaniec-Šverák theorem to metric surfaces: a non-constant

$$f:X \rightarrow \mathbb {R}^2$$

f
:
X
→

R

2

with locally square integrable upper gradient and locally integrable distortion is continuous, open and discrete. We also extend the Hencl-Koskela theorem by showing that if f is moreover injective then

$$f^{-1}$$

f

-
1

is a Sobolev map.
A single-center retrospective comparison of pT1 substaging methods in bladder cancer
Authors: Kläger Johannes , Koeller Maximilian C. , Oszwald André , Wasinger Gabriel , D’Andrea David , Compérat Eva 
Published: September 2024

AbstractSubstaging of T1 urothelial cancer is associated with tumor progression and its reporting is recommended by international guidelines. However, it has not been integrated in risk stratification tools and there is no agreement on the best method to use for its reporting. We aimed to investigate the applicability, interobserver variability, and prognostic value of histological landmark based and micrometric (aggregate linear length of invasive carcinoma (ALLICA), microscopic vs. extensive system, Rete Oncologica Lombarda (ROL) system) substaging methods. A total of 79 patients with the primary diagnosis of T1 urothelial cancer treated with conventional transurethral resection and adjuvant BCG therapy between 2000 and 2020 at the Medical University of Vienna were included. The anatomical and metrical substaging systems were evaluated using agreement rate, Cohen’s kappa, Kendall’s tau, and Spearman rank correlation. Prognostic value for high-grade recurrence or T2 progression was evaluated in uni- and multivariable analysis. Applicability and reproducibility were good to moderate and varied between substaging methods. Obstacles are mainly due to fragmentation of samples. Anatomical substaging was associated with progression in univariable and multivariable analysis. In our cohort, we could only identify anatomical landmark–based substaging to be prognostic for T2 progression. A major obstacle for proper pathological assessment is fragmentation of samples due to operational procedure. Avoiding such fragmentation might improve reproducibility and significance of pathological T1 substaging of urothelial cancer.
Optihybrid: a modified firebug swarm optimization algorithm for optimal sizing of hybrid renewable power system
Authors: Abd El-Sattar Hoda , Kamel Salah , Hashim Fatma A. , Sabbeh Sahar F. 
Published: September 2024

AbstractIn areas where conventional energy sources are unavailable, alternative energy technologies play a crucial role in generating electricity. These technologies offer various benefits, such as reliable energy supply, environmental sustainability, and employment opportunities in rural regions. This study focuses on the development of a novel optimization algorithm called the modified firebug swarm algorithm (mFSO). Its objective is to determine the optimal size of an integrated renewable power system for supplying electricity to a specific remote site in Dehiba town, located in the eastern province of Tataouine, Tunisia. The proposed configuration for the standalone hybrid system involves PV/biomass/battery, and three objective functions are considered: minimizing the total energy cost (COE), reducing the loss of power supply probability (LPSP), and managing excess energy (EXC). The effectiveness of the modified algorithm is evaluated using various tests, including the Wilcoxon test, boxplot analysis, and the ten benchmark functions of the CEC2020 benchmark. Comparative analysis between the mFSO and widely used algorithms like the original Firebug Swarm Optimization (FSO), Slime Mold Algorithm (SMA), and Seagull Optimization Algorithm (SOA) demonstrates that the proposed mFSO technique is efficient and effective in solving the design problem, surpassing other optimization algorithms.
Long-term outcomes of sentinel lymph node navigation surgery for early-stage cervical cancer
Authors: Togami Shinichi , Furuzono Nozomi , Mizuno Mika , Yanazume Shintaro , Kobayashi Hiroaki 
Published: September 2024

Abstract
Background
Sentinel lymph node navigation surgery, which identifies the sentinel lymph node in early cervical cancers and omits systemic pelvic lymphadenectomy in cases where no lymph node metastasis is present, has recently gained attention. However, there are few reports on lymph node recurrence and the long-term outcomes of cervical cancer surgery performed using sentinel lymph node navigation surgery. In this study, we aimed to evaluate the long-term outcomes of sentinel node navigation surgery for early-stage cervical cancer.

Methods
One hundred thirty-eight patients with cervical cancer were enrolled. Sentinel lymph nodes were identified by injecting 99 m Technetium-labeled phytate and indocyanine green into the uterine cervix. Surgery and survival outcomes were also analyzed.

Results
The median age and body mass index of the patients were 40 years (20–78) and 21.7 kg/m2 (16.5–50.4), respectively. Open surgery, laparoscopic surgery, and robotic surgery were performed in 77 (56%), 53 (38%), and 8 (6%) patients, respectively. The overall and bilateral detection rates of the sentinel lymph node were 100% and 94%, respectively. Only one case (0.7%) exhibited lower extremity lymphedema, and pelvic lymphocele was observed in three cases (2.2%). Four cases (3%) experienced recurrence over a median follow-up of 57.5 months (range, 2–115 months), with five-year recurrence-free and overall survival rates of 97% and 97.3%, respectively.

Conclusions
Our results demonstrate that sentinel node navigation surgery may be safe and effective for early-stage cervical cancer.
Clinical outcomes of first-line combination therapy with immune checkpoint inhibitor for metastatic non-clear cell renal cell carcinoma: a multi-institutional retrospective study in Japan
Authors: Yoshimura Akihiro , Kato Taigo , Nakai Yasutomo , Tsujihata Masao , Toyoda Shingo , Sato Mototaka , Matsuzaki Kyosuke , Nakata Wataru , Takao Tetsuya , Inoguchi Syunsuke , Okuda Yohei , Yamamichi Gaku , Ishizuya Yu , Yamamoto Yoshiyuki , Hatano Koji , Kawashima Atsunari , Takada Shingo , Inoue Hitoshi , Nishimura Kensaku , Miyake Osamu , Fujita Kazutoshi , Nakayama Masashi , Nishimura Kazuo , Nonomura Norio 
Published: September 2024

Abstract
Background
In metastatic clear cell renal cell carcinoma (ccRCC), recent studies have shown promising efficacy of immune checkpoint inhibitor (ICI) combination therapy. However, there are insufficient evidences about clinical efficacy and safety of ICI combination therapy in metastatic non-ccRCC (nccRCC).

Methods
We retrospectively investigated 44 patients treated with nivolumab plus ipilimumab (ICI + ICI group) or anti-PD-1/PD-L1 inhibitor plus tyrosine kinase inhibitors (TKI) (ICI + TKI group), and assessed clinical efficacy in both groups.

Results
Of all patients, overall response rate and disease control rate for ICI combination treatments were 36.3% and 75%, respectively. The median progression-free survival (PFS) and overall survival (OS) was 8.8 and 23.9 months, respectively. Multivariate analysis revealed that the presence of liver metastasis significantly affected worse PFS and OS (p = 0.035 and p = 0.049). Importantly, PFS and OS seemed similar in ICI + ICI group and ICI + TKI group (p = 0.778 and p = 0.559). Although the discontinuation rate of the combination therapy due to adverse effects in patients aged ≥ 75 years was significantly higher compared to that in patients aged < 75 years (45% versus 12%, p = 0.017), there were no significant differences in PFS and OS between two groups (p = 0.290 and p = 0.257, respectively).

Conclusion
This study confirms clinical benefit of ICI combination therapy for metastatic nccRCC patients in real-world settings. Furthermore, the effectiveness of combination therapy was comparable between patients aged < 75 and those ≥75 years with respect to clinical prognosis.
Evaluation under loading detects medial meniscus extrusion in patients with reconstructed anterior cruciate ligament and restricted knee extension
Authors: Ishii Yosuke , Nakamae Atsuo , Akinori Nekomoto , Hashizume Takato , Okinaka Riko , Sugimoto Miharu , Matsumura Kohei , Ishikawa Masakazu , Takahashi Makoto , Adachi Nobuo 
Published: September 2024

Abstract
Purpose
Some patients who undergo anterior cruciate ligament (ACL) reconstruction experience abnormal mechanical stress in the meniscus. Medial meniscal extrusion (MME) is reflected in the pathological condition of the meniscus, which expands owing to repetitive mechanical stress. Thus, the effect of the reconstructed ACL on increasing MME under weight-bearing conditions remains unclear. This study investigated the effect of ACL reconstruction on meniscal extrusion under non-weight-bearing and weight-bearing conditions.

Methods
Seventeen patients who underwent unilateral ACL reconstruction (ACL group) and 20 age-matched healthy volunteers (control group) were enrolled. Ultrasonography was performed in the supine, standing, and walking positions in preoperative and postoperative ACL patients. MME during walking was evaluated based on the dynamic behavior of extrusion, and kinetic and kinematic data were synchronously obtained. Moreover, the ACL group underwent magnetic resonance imaging (MRI) evaluation at two points: preoperatively and 12 months postoperatively, and the ultrasound findings were compared.

Results
MME in the supine position measured using both ultrasonography and MRI was not significantly different preoperatively and postoperatively in the ACL group. However, postoperative MME and dynamic behavior of extrusion under standing and walking conditions were significantly higher than those in the preoperative state (dynamic behavior: 0.9 ± 0.4 mm preoperatively, 1.2 ± 0.4 mm postoperatively). Moreover, the deficits in knee extension during walking persisted postoperatively and were significantly higher than those in the control group.

Conclusion
MME in patients with ACL reconstruction including meniscus repair was different under mechanical stress compared to the non-weight bearing condition.
BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition
Authors: Pervushin N. V. , Nilov D. K. , Pushkarev S. V. , Shipunova V. O. , Badlaeva A. S. , Yapryntseva M. A. , Kopytova D. V. , Zhivotovsky B. , Kopeina G. S. 
Published: September 2024

AbstractThe development of drug resistance reduces the efficacy of cancer therapy. Tumor cells can acquire resistance to MDM2 inhibitors, which are currently under clinical evaluation. We generated RG7388-resistant neuroblastoma cells, which became more proliferative and metabolically active and were less sensitive to DNA-damaging agents in vitro and in vivo, compared with wild-type cells. The resistance was associated with a mutation of the p53 protein (His193Arg). This mutation abated its transcriptional activity via destabilization of the tetrameric p53-DNA complex and was observed in many cancer types. Finally, we found that Cisplatin and various BH3-mimetics could enhance RG7388-mediated apoptosis in RG7388-resistant neuroblastoma cells, thereby partially overcoming resistance to MDM2 inhibition.
Carboxymethylation of viscose and cotton fibers: comparisons of water retention and moisture sorption
Authors: Bogner Paul , Schlapp-Hackl Inge , Hummel Michael , Bechtold Thomas , Pham Tung , Manian Avinash P. 
Published: September 2024

AbstractThe aim of the work was to compare the water retention and moisture sorption of viscose (CV) and cotton (Co) fibers carboxymethylated from aqueous media, in presence of NaOH, with sodium monochloroacetate. It was shown previously that under the same treatment conditions, the degree of carboxymethylation was higher in CV and so was the depth within fiber structures to which the carboxymethylation reactions occurred. It was also shown previously, that in terms of their capacity for sorption of a cationic dye (methylene blue), the Co performed better than CV. In this work, the same fibers were tested for their water retention and moisture sorption propensities. The two were sensitive both to the degree of carboxymethylation and the inherent properties of fibers (accessibility, degree of swelling, hornification). But the moisture sorption levels were less sensitive to the degree of carboxymethylation and more to inherent fiber properties whereas the reverse was observed for water retention. In contrast to the prior observations with dye sorption, CV performed better than Co in both moisture sorption and water retention. The poor performance of CV in dye sorption was attributed to the greater depth of carboxymethylation within the fibers that hindered dye permeation, but the same feature was observed to result in better performance (water retention) or not to hinder performance (moisture sorption). These observations highlight the contrasting effects that may arise, of a given set of treatment parameters (fiber type, alkali level in treatment), on efficacy of the product performance.
Population genetic structure and range limits of Prostanthera cineolifera (Lamiaceae), a vulnerable shrub with a patchy distribution
Authors: Palsson Ruth L. , Telford Ian R. H. , Bruhl Jeremy J. , Andrew Rose L. 
Published: September 2024

AbstractIntegrating molecular data is essential for clarifying the distributions and genetic structures of species that have histories of misidentification and misapplication of names. There has been confusion about the species limits of the Vulnerable Prostanthera cineolifera with respect to morphologically similar specimens in the Hunter Valley, New South Wales, Australia and morphologically dissimilar specimens in the Lower Hawkesbury Valley, New South Wales, and from north-eastern New South Wales. To test the species limits of P. cineolifera, and related taxa, specimens were collected from across the range and augmented with herbarium specimens. We used morphometric analysis of 18 morphological characters across 51 samples. Using the DArTseq reduced representation sequencing platform, 4010 single-nucleotide polymorphisms (SNPs) across 110 individuals were recovered for molecular analysis. Both morphological and molecular analyses produced three concordant clusters (A) P. cineolifera, (B) a group sharing similarities with P. sp. Hawkesbury (B.J.Conn 2591), and (C) a group allied with P. lanceolata and P. ovalifolia. These results indicate that the specimens form north-eastern New South Wales are more likely to be P. lanceolata, not P. cineolifera, and that specimens from the Lower Hawkesbury are of an undescribed species with the phrase name P. sp. Hawkesbury (B.J.Conn 2591). Within P. cineolifera there was pronounced genetic differentiation among populations. Little evidence of inbreeding was observed, but the newly recognised, more isolated populations had the lowest genetic diversity. This study provides new information about the range of the species and its genetic structure that informs the conservation priorities for this species.
Perceptions versus performance: Assessing teacher learning in asynchronous online professional development
Authors: Li Jingxian , Copur-Gencturk Yasemin 
Published: September 2024

AbstractTeacher learning in asynchronous online professional development (PD) is often measured by self-reported instruments, despite uncertainties regarding teachers’ accuracy in their self-assessment of learning. This study explored whether teachers’ self-reported gains in content knowledge for teaching aligned with those measured by direct assessments. Through quantitative analyses of data collected from 57 middle school mathematics teachers who participated in a fully asynchronous online PD program, we found no significant correlation between teachers’ self-reported knowledge gains and those measured by direct assessments. Additionally, we examined the role of teachers’ use of self-regulated learning (SRL) strategies, namely organization, elaboration, and monitoring, in their learning from the PD program by conducting linear regression analyses. Our results indicated that teachers who frequently monitored their understanding of the PD content demonstrated greater gains in their content knowledge as measured by direct assessments. However, none of the SRL strategies predicted the accuracy of teachers’ self-assessments of knowledge gains from the asynchronous online PD program. These findings raise concerns about relying solely on self-reported instruments to capture teachers’ learning in asynchronous online PD programs, and they emphasize the need for more robust and accurate outcome measures in the asynchronous online learning context.