bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standardization of hemipelvis alignment for in vitro biomechanical testing
Authors: Morosato Federico , Traina Francesco , Cristofolini Luca 
Published: November 2017

ABSTRACTAlthough in vitro biomechanical tests are regularly performed, the definition of a suitable reference frame for hemipelvic specimens is still a challenge. The aims of the present study were to: (i) define a reference frame for the human hemipelvis suitable for in vitro applications, based on robust anatomical landmarks; (ii) identify the alignment of a hemipelvis based on the alignment of a whole pelvis (including right/left and male/female differences); (iii) identify the relative alignment of the proposed in vitro reference frame with respect to a reference frame commonly used in gait analysis; (iv) create an in vitro alignment procedure easy, robust and inexpensive; (v) quantify the intra‐operator repeatability and inter‐operator reproducibility of the procedure. A procedure to univocally identify the anatomical landmarks was created, exploiting the in vitro accessibility of the specimen's surface. Through the analysis on 53 CT scans (106 hemipelvises), the alignment of the hemipelvis based on the alignment of a whole pelvis was analyzed: differences between male/female and right/left hemipelvises were not statistically significant To overcome the uncertainty in the identification of the acetabular rim, a standard acetabular plane was defined. An alignment procedure was developed to implement such anatomical reference frame. The intra‐operator repeatability and the inter‐operator reproducibility were quantified with four operators, on male and female hemipelvises. The intra‐operator repeatability was better than 1.5°. The inter‐operator reproducibility was better than 2.0°. Alignment in the transverse plane was the most repeatable. The presented procedure to align hemipelvic specimens is sufficiently robust, standardized, and accessible. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1645–1652, 2018.
Decreasing sentences in Simple Type Theory
Authors: Rouvelas Panagiotis 
Published: November 2017

AbstractWe present various results regarding the decidability of certain sets of sentences by Simple Type Theory (). First, we introduce the notion of decreasing sentence, and prove that the set of decreasing sentences is undecidable by Simple Type Theory with infinitely many zero‐type elements (); a result that follows directly from the fact that every sentence is equivalent to a decreasing sentence. We then establish two different positive decidability results for a weak subtheory of. Namely, the decidability of(a subset of Σ1) and(the set of all sentences, where φ is strictly decreasing). Finally, we present some consequences for the set of existential‐universal sentences. All the above results have direct implications for Quine's theory of “New Foundations” () and its weak subtheory.
The Hypothesis and a supercompact cardinal
Authors: Cheng Yong 
Published: November 2017

AbstractIn this paper, we prove that: if κ is supercompact and the Hypothesis holds, then there is a proper class of regular cardinals in which are measurable in . Woodin also proved this result independently . As a corollary, we prove Woodin's Local Universality Theorem. This work shows that under the assumption of the Hypothesis and supercompact cardinals, large cardinals in are reflected to be large cardinals in in a local way, and reveals the huge difference between ‐supercompact cardinals and supercompact cardinals under the Hypothesis.
Deltamethrin is metabolized by CYP6FU1, a cytochrome P450 associated with pyrethroid resistance, in Laodelphax striatellus
Authors: Elzaki Mohammed Esmail Abdalla , Miah Mohammad Asaduzzaman , Peng Yingchuan , Zhang Haomiao , Jiang Ling , Wu Min , Han Zhaojun 
Published: November 2017

AbstractBACKGROUNDCytochrome P450s (CYPs) are known to play a major role in metabolizing a wide range compounds. CYP6FU1 has been found to be over‐expressed in a deltamethrin‐resistant strain of Laodelphax striatellus. This study was conducted to express CYP6FU1 in Sf9 cells as a recombinant protein, to confirm its ability to degrade deltamethrin, chlorpyrifos, imidacloprid and traditional P450 probing substrates.RESULTSCarbon monoxide difference spectrum analysis indicated that the intact CYP6FU1 protein was expressed in insect Sf9 cells. Catalytic activity tests with four traditional P450 probing substrates revealed that the expressed CYP6FU1 preferentially metabolized p‐nitroanisole and ethoxyresorufin, but not ethoxycoumarin and luciferin‐HEGE. The enzyme kinetic parameters were tested using p‐nitroanisole. The michaelis constant (Km) and catalytic constant (Kcat) values were 17.51 ± 4.29 µm and 0.218 ± 0.001 pmol min−1 mg−1 protein, respectively. Furthermore, CYP6FU1 activity for degradation of insecticides was tested by measuring substrate depletion and metabolite formation. The chromatogram analysis showed obvious nicotinamide‐adenine dinucleotide phosphate (NADPH)‐dependent depletion of deltamethrin, and formation of the unknown metabolite. Mass spectra and the molecular docking model showed that the metabolite was 4‐hydroxy‐deltamethrin. However, the recombinant CYP6FU1 could not metabolize imidacloprid and chlorpyrifos.CONCLUSIONThese results confirmed that the over‐expressed CYP6FU1 contributes to deltamethrin resistance in L. striatellus, and p‐nitroanisole might be a potential diagnostic probe for deltamethrin metabolic resistance detection and monitoring. © 2017 Society of Chemical Industry
Eleven-dimensional supergravity in 4D, N = 1 superspace
Authors: Becker Katrin , Becker Melanie , Butter Daniel , Guha Sunny , Linch William D. , Robbins Daniel 
Published: November 2017

AbstractWe give a formulation of linearized 11D supergravity in 4D,N= 1 superspace keeping all eleven bosonic coordinates. The fields are fluctuations aroundM=R4|4×Y, whereYis a background Riemannian 7-manifold admitting aG2structure. We embed the 11D fields into superfield representations of the 4D,N= 1 superconformal algebra. These consist of the conformal graviton superfield, seven conformal gravitino superfields, a tensor hierarchy of superfields describing the 11D 3-form, and a non-abelian Kaluza-Klein vector multiplet gauging the tensor hierarchy by diffeomorphisms onY. The quadratic action consists of the linearization of a superspace volume term and a Chern-Simons action for the gauged hierarchy coupled to the supergravity and gravitino superfields, and the full structure is fixed by superconformal and gauge invariance. When this action is projected to components, we recover the full linearized action of 11D supergravity.
Long-term carbon sink in Borneo’s forests halted by drought and vulnerable to edge effects
Authors: Qie Lan , Lewis Simon L. , Sullivan Martin J. P. , Lopez-Gonzalez Gabriela , Pickavance Georgia C. , Sunderland Terry , Ashton Peter , Hubau Wannes , Abu Salim Kamariah , Aiba Shin-Ichiro , Banin Lindsay F. , Berry Nicholas , Brearley Francis Q. , Burslem David F. R. P. , Dančák Martin , Davies Stuart J. , Fredriksson Gabriella , Hamer Keith C. , Hédl Radim , Kho Lip Khoon , Kitayama Kanehiro , Krisnawati Haruni , Lhota Stanislav , Malhi Yadvinder , Maycock Colin , Metali Faizah , Mirmanto Edi , Nagy Laszlo , Nilus Reuben , Ong Robert , Pendry Colin A. , Poulsen Axel Dalberg , Primack Richard B. , Rutishauser Ervan , Samsoedin Ismayadi , Saragih Bernaulus , Sist Plinio , Slik J. W. Ferry , Sukri Rahayu Sukmaria , Svátek Martin , Tan Sylvester , Tjoa Aiyen , van Nieuwstadt Mark , Vernimmen Ronald R. E. , Yassir Ishak , Kidd Petra Susan , Fitriadi Muhammad , Ideris Nur Khalish Hafizhah , Serudin Rafizah Mat , Abdullah Lim Layla Syaznie , Saparudin Muhammad Shahruney , Phillips Oliver L. 
Published: November 2017

AbstractLess than half of anthropogenic carbon dioxide emissions remain in the atmosphere. While carbon balance models imply large carbon uptake in tropical forests, direct on-the-ground observations are still lacking in Southeast Asia. Here, using long-term plot monitoring records of up to half a century, we find that intact forests in Borneo gained 0.43 Mg C ha−1 per year (95% CI 0.14–0.72, mean period 1988–2010) in above-ground live biomass carbon. These results closely match those from African and Amazonian plot networks, suggesting that the world’s remaining intact tropical forests are now en masse out-of-equilibrium. Although both pan-tropical and long-term, the sink in remaining intact forests appears vulnerable to climate and land use changes. Across Borneo the 1997–1998 El Niño drought temporarily halted the carbon sink by increasing tree mortality, while fragmentation persistently offset the sink and turned many edge-affected forests into a carbon source to the atmosphere.
Multiplexed computations in retinal ganglion cells of a single type
Authors: Deny Stéphane , Ferrari Ulisse , Macé Emilie , Yger Pierre , Caplette Romain , Picaud Serge , Tkačik Gašper , Marre Olivier 
Published: November 2017

AbstractIn the early visual system, cells of the same type perform the same computation in different places of the visual field. How these cells code together a complex visual scene is unclear. A common assumption is that cells of a single-type extract a single-stimulus feature to form a feature map, but this has rarely been observed directly. Using large-scale recordings in the rat retina, we show that a homogeneous population of fast OFF ganglion cells simultaneously encodes two radically different features of a visual scene. Cells close to a moving object code quasilinearly for its position, while distant cells remain largely invariant to the object’s position and, instead, respond nonlinearly to changes in the object’s speed. We develop a quantitative model that accounts for this effect and identify a disinhibitory circuit that mediates it. Ganglion cells of a single type thus do not code for one, but two features simultaneously. This richer, flexible neural map might also be present in other sensory systems.
A feasibility study of neoadjuvant talazoparib for operable breast cancer patients with a germline BRCA mutation demonstrates marked activity
Authors: Litton J. K. , Scoggins M. , Ramirez D. L. , Murthy R. K. , Whitman G. J. , Hess K. R. , Adrada B. E. , Moulder S. L. , Barcenas C. H. , Valero V. , Gomez J. Schwartz , Mittendorf E. A. , Thompson A. , Helgason T. , Mills G. B. , Piwnica-Worms H. , Arun B. K. 
Published: November 2017

AbstractThis study was undertaken to determine the feasibility of enrolling breast cancer patients on a single-agent-targeted therapy trial before neoadjuvant chemotherapy. Specifically, we evaluated talazoparib in patients harboring a deleterious BRCA mutation (BRCA+). Patients with a germline BRCA mutation and ≥1 cm, HER2-negative primary tumors were eligible. Study participants underwent a pretreatment biopsy, 2 months of talazoparib, off-study core biopsy, anthracycline, and taxane-based chemotherapy ± carboplatin, followed by surgery. Volumetric changes in tumor size were determined by ultrasound at 1 and 2 months of therapy. Success was defined as 20 patients accrued within 2 years and <33% experienced a grade 4 toxicity. The study was stopped early after 13 patients (BRCA1 + n = 10; BRCA2 + n = 3) were accrued within 8 months with no grade 4 toxicities and only one patient requiring dose reduction due to grade 3 neutropenia. The median age was 40 years (range 25–55) and clinical stage included I (n = 2), II (n = 9), and III (n = 2). Most tumors (n = 9) were hormone receptor-negative, and one of these was metaplastic. Decreases in tumor volume occurred in all patients following 2 months of talazoparib; the median was 88% (range 30–98%). Common toxicities were neutropenia, anemia, thrombocytopenia, nausea, dizziness, and fatigue. Single-agent-targeted therapy trials are feasible in BRCA+ patients. Given the rapid rate of accrual, profound response and favorable toxicity profile, the feasibility study was modified into a phase II study to determine pathologic complete response rates after 4–6 months of single-agent talazoparib.
A robot-aided visuo-motor training that improves proprioception and spatial accuracy of untrained movement
Authors: Elangovan Naveen , Cappello Leonardo , Masia Lorenzo , Aman Joshua , Konczak Jürgen 
Published: November 2017

AbstractProprioceptive function can become enhanced during motor learning. Yet, we have incomplete knowledge to what extent proprioceptive function is trainable and how a training that enhances proprioception may influence performance in untrained motor skills. To address this knowledge gap, healthy young adults (N = 14) trained in a visuomotor task that required learners to make increasingly accurate wrist movements. Using a robotic exoskeleton coupled with a virtual visual environment, participants tilted a virtual table through continuous wrist flexion/extension movements with the goal to position a rolling ball on table into a target. With learning progress, the level of difficulty increased by altering the virtual ball mechanics and the gain between joint movement and ball velocity. Before and after training, wrist position sense acuity and spatial movement accuracy in an untrained, discrete wrist-pointing task was assessed using the same robot. All participants showed evidence of proprioceptive-motor learning. Mean position sense discrimination threshold improved by 34%. Wrist movement accuracy in the untrained pointing task improved by 27% in 13/14 participants. This demonstrates that a short sensorimotor training challenging proprioception can a) effectively enhance proprioceptive acuity and b) improve the accuracy of untrained movement. These findings provide a scientific basis for applying such somatosensory-based motor training to clinical populations with known proprioceptive dysfunction to enhance sensorimotor performance.
Mineral analysis of complete dog and cat foods in the UK and compliance with European guidelines
Authors: Davies M. , Alborough R. , Jones L. , Davis C. , Williams C. , Gardner D. S. 
Published: November 2017

AbstractMineral content of complete pet food is regulated to ensure health of the companion animal population. Analysis of adherence to these regulatory guidelines has not been conducted. Here, mineral composition of complete wet (n = 97) and dry (n = 80) canine and feline pet food sold in the UK was measured to assess compliance with EU guidelines. A majority of foods complied with ≥8 of 11 guidelines (99% and 83% for dry and wet food, respectively), but many failed to provide nutritional minimum (e.g. Cu, 20% of wet food) or exceeded nutritional maximum (e.g. Se, 76% of wet food). Only 6% (6/97) of wet and 38% (30/80) of dry food were fully compliant. Some foods (20–30% of all analysed) had mineral imbalance, such as not having the recommended ratio of Ca:P (between 1:1 to 2:1). Foods with high fish content had high levels of undesirable metal elements such as arsenic. This study highlights broad non-compliance of a range of popular pet foods sold in the UK with EU guidelines (94% and 61% of wet and dry foods, respectively). If fed exclusively and over an extended period, a number of these pet foods could impact the general health of companion animals.
Musical Imagery Involves Wernicke’s Area in Bilateral and Anti-Correlated Network Interactions in Musicians
Authors: Zhang Yizhen , Chen Gang , Wen Haiguang , Lu Kun-Han , Liu Zhongming 
Published: November 2017

AbstractMusical imagery is the human experience of imagining music without actually hearing it. The neural basis of this mental ability is unclear, especially for musicians capable of engaging in accurate and vivid musical imagery. Here, we created a visualization of an 8-minute symphony as a silent movie and used it as real-time cue for musicians to continuously imagine the music for repeated and synchronized sessions during functional magnetic resonance imaging (fMRI). The activations and networks evoked by musical imagery were compared with those elicited by the subjects directly listening to the same music. Musical imagery and musical perception resulted in overlapping activations at the anterolateral belt and Wernicke’s area, where the responses were correlated with the auditory features of the music. Whereas Wernicke’s area interacted within the intrinsic auditory network during musical perception, it was involved in much more complex networks during musical imagery, showing positive correlations with the dorsal attention network and the motor-control network and negative correlations with the default-mode network. Our results highlight the important role of Wernicke’s area in forming vivid musical imagery through bilateral and anti-correlated network interactions, challenging the conventional view of segregated and lateralized processing of music versus language.
Plasma metabolomic profile varies with glucocorticoid dose in patients with congenital adrenal hyperplasia
Authors: Alwashih Mohammad A. , Watson David G. , Andrew Ruth , Stimson Roland H. , Alossaimi Manal , Blackburn Gavin , Walker Brian R. 
Published: November 2017

AbstractGlucocorticoid replacement therapy is the mainstay of treatment for congenital adrenal hyperplasia (CAH) but has a narrow therapeutic index and dose optimisation is challenging. Metabolomic profiling was carried out on plasma samples from 117 adults with 21-hydroxylase deficiency receiving their usual glucocorticoid replacement therapy who were part of the CaHASE study. Samples were profiled by using hydrophilic interaction chromatography with high resolution mass spectrometry. The patients were also profiled using nine routine clinical measures. The data were modelled by using both multivariate and univariate statistics by using the clinical metadata to inform the choice of patient groupings. Comparison of 382 metabolites amongst groups receiving different glucocorticoid doses revealed a clear distinction between patients receiving ≤5 mg (n = 64) and >5 mg (n = 53) daily prednisolone-equivalent doses. The 24 metabolites which were statistically significantly different between groups included free fatty acids, bile acids, and amino acid metabolites. Using 7 metabolites improved the receiver operating characteristic with area under the curve for predicting glucocorticoid dose of >0.9 with FDR adjusted P values in the range 3.3 E-04 -1.9 E-10. A combination of seven plasma metabolite biomarkers readily discriminates supraphysiological glucocorticoid replacement doses in patients with CAH.
Strain induced band inversion and topological phase transition in methyl-decorated stanene film
Authors: Wang Dongchao , Chen Li , Liu Hongmei , Shi Changmin , Wang Xiaoli , Cui Guangliang , Zhang Pinhua , Chen Yeqing 
Published: November 2017

AbstractThe researches for new quantum spin Hall (QSH) insulators with large bulk energy gap are of much significance for their practical applications at room temperature in electronic devices with low-energy consumption. By means of first-principles calculations, we proposed that methyl-decorated stanene (SnCH3) film can be tuned into QSH insulator under critical tensile strain of 6%. The nonzero topological invariant and helical edge states further confirm the nontrivial nature in stretched SnCH3 film. The topological phase transition originates from the s-p
xy
type band inversion at the Γ point with the strain increased. The spin-orbital coupling (SOC) induces a large band gap of ~0.24 eV, indicating that SnCH3 film under strain is a quite promising material to achieve QSH effect. The proper substrate, h-BN, finally is presented to support the SnCH3 film with nontrivial topology preserved.
Brain-to-Brain Synchrony during Naturalistic Social Interactions
Authors: Kinreich Sivan , Djalovski Amir , Kraus Lior , Louzoun Yoram , Feldman Ruth 
Published: November 2017

AbstractThe evolution of humans as a highly social species tuned the brain to the social world; yet the mechanisms by which humans coordinate their brain response online during social interactions remain unclear. Using hyperscanning EEG recordings, we measured brain-to-brain synchrony in 104 adults during a male-female naturalistic social interaction, comparing romantic couples and strangers. Neural synchrony was found for couples, but not for strangers, localized to temporal-parietal structures and expressed in gamma rhythms. Brain coordination was not found during a three-minute rest, pinpointing neural synchrony to social interactions among affiliative partners. Brain-to-brain synchrony was linked with behavioral synchrony. Among couples, neural synchrony was anchored in moments of social gaze and positive affect, whereas among strangers, longer durations of social gaze and positive affect correlated with greater neural synchrony. Brain-to-brain synchrony was unrelated to episodes of speech/no-speech or general content of conversation. Our findings link brain-to-brain synchrony to the degree of social connectedness among interacting partners, ground neural synchrony in key nonverbal social behaviors, and highlight the role of human attachment in providing a template for two-brain coordination.
Double‐sided CL compensation topology based component voltage stress optimisation method for capacitive power transfer charging system
Authors: Mai Ruikun , Luo Bo , Chen Yangqi , He Zhengyou 
Published: November 2017

A double‐sided capacitor–inductor (CL) compensation topology is proposed for high‐power capacitive power transfer (CPT) charging systems with a component voltage stress optimisation to alleviate the voltage stress on passive components and coupling interfaces. First, detailed analysis of the compensation topology characteristic is carried out based on fundamental harmonics approximation analysis method to yield the voltage stress functions against system's parameters. Then, a voltage stress optimisation is presented. Third, system component voltage stress can be reallocated effectively according to the desired requirement by adjusting system parameters accordingly. With the proposed voltage stress optimisation, a CPT prototype is set up to verify the proposed method performance. As per the experiment results, the efficiency of the prototype reaches 87.47% with 1494 W output power from DC to DC at the 1 MHz switching frequency. Besides, the maximum voltage stress is significantly reduced compared to that without optimisation.
Metastasis of a Dorsal Melanoma to a Pituitary Adenoma Mimicking Pituitary Apoplexy
Authors: Ramos Rui , Machado Maria , Antunes Cristiano , Fernandes Vera , Marques Olinda , Almeida Rui 
Published: November 2017

AbstractMetastases to pituitary adenomas are very rare. From the 20 cases found in the literature, none originated from a cutaneous melanoma. We present the case of a 67-year-old man with a history of transcranial approach to treat a pituitary macroadenoma followed by adjuvant radiotherapy. Fifteen years later, he presented a dorsal nodular melanoma, and three years after that, he developed symptoms of pituitary apoplexy. He was submitted to transsphenoidal surgery, and the histology result revealed metastasis of the melanoma into a pituitary adenoma.The similarity in the clinical presentation of the two entities—pituitary apoplexy and metastasis of the melanoma into a pituitary adenoma—and the rarity of this type of metastization alert to challenges in the differential diagnosis that may confound the neurosurgeon's decision.