bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognostic Impacts of Plasma Levels of Cyclophilin A in Patients With Coronary Artery Disease
Authors: Ohtsuki Tomohiro , Satoh Kimio , Omura Junichi , Kikuchi Nobuhiro , Satoh Taijyu , Kurosawa Ryo , Nogi Masamichi , Sunamura Shinichiro , Yaoita Nobuhiro , Aoki Tatsuo , Tatebe Shunsuke , Sugimura Koichiro , Takahashi Jun , Miyata Satoshi , Shimokawa Hiroaki 
Published: February 2017

Objective—
Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells, inflammatory cells, and activated platelets in response to oxidative stress. We have recently demonstrated that plasma CyPA level is a novel biomarker for diagnosing coronary artery disease. However, it remains to be elucidated whether plasma CyPA levels also have a prognostic impact in such patients.

Approach and Results—

In 511 consecutive patients undergoing diagnostic coronary angiography, we measured the plasma levels of CyPA, high-sensitivity C-reactive protein (hsCRP), and brain natriuretic peptide and evaluated their prognostic impacts during the follow-up (42 months, interquartile range: 25–55 months). Higher CyPA levels (≥12 ng/mL) were significantly associated with all-cause death, rehospitalization, and coronary revascularization. Higher hsCRP levels (≥1 mg/L) were also significantly correlated with the primary end point and all-cause death, but not with rehospitalization or coronary revascularization. Similarly, higher brain natriuretic peptide levels (≥100 pg/mL) were significantly associated with all-cause death and rehospitalization, but not with coronary revascularization. Importantly, the combination of CyPA (≥12 ng/mL) and hsCRP (≥1 mg/L) was more significantly associated with all-cause death (hazard ratio, 21.2; 95% confidence interval, 4.9–92.3,;
P
<0.001) than CyPA (≥12 ng/mL) or hsCRP (≥1 mg/L) alone.

Conclusions—
The results indicate that plasma CyPA levels can be used to predict all-cause death, rehospitalization, and coronary revascularization in patients with coronary artery disease and that when combined with other biomarkers (hsCRP and brain natriuretic peptide levels), the CyPA levels have further enhanced prognostic impacts in those patients.
Leisure activities and mobility device use among very old people in Latvia and in Sweden
Authors: Kylberg Marianne , Löfqvist Charlotte , Horstmann Vibeke , Iwarsson Susanne 
Published: February 2017

Introduction Opportunities for leisure activities and physical mobility are important for the ageing population. Therefore, we aim to describe leisure activities outside the home among very old (over 80 years of age) users and non-users of mobility devices in two European countries. Method Survey data on mobility device use, self-rated physical mobility and leisure activities outside the home were utilised for a Latvian ( n = 225) and Swedish ( n = 314) sample. Differences in type and number of leisure activities were studied between the countries and for four groups of participants according to use/non-use of and level of physical mobility. Results Significant differences in type and number of leisure activities were seen between the national samples and among the participant groups. In general, each participant group in the Swedish sample reported more leisure activities than did those in the Latvian sample. Non-users with good physical mobility reported significantly more leisure activities than all other participant groups. Conclusion There are differences between the two national contexts in the type and number of leisure activities reported. To support very old people’s participation in outdoor leisure activities, we need more knowledge as to how physical, institutional and sociocultural environments affect very old people’s opportunities to engage in and perform such activities.
Determination of multidirectional myocardial deformations in cats with hypertrophic cardiomyopathy by using two-dimensional speckle-tracking echocardiography
Authors: Suzuki Ryohei , Mochizuki Yohei , Yoshimatsu Hiroki , Teshima Takahiro , Matsumoto Hirotaka , Koyama Hidekazu 
Published: February 2017

Objectives Hypertrophic cardiomyopathy, a primary disorder of the myocardium, is the most common cardiac disease in cats. However, determination of myocardial deformation with two-dimensional speckle-tracking echocardiography in cats with various stages of hypertrophic cardiomyopathy has not yet been reported. This study was designed to measure quantitatively multidirectional myocardial deformations of cats with hypertrophic cardiomyopathy. Methods Thirty-two client-owned cats with hypertrophic cardiomyopathy and 14 healthy cats serving as controls were enrolled and underwent assessment of myocardial deformation (peak systolic strain and strain rate) in the longitudinal, radial and circumferential directions. Results Longitudinal and radial deformations were reduced in cats with hypertrophic cardiomyopathy, despite normal systolic function determined by conventional echocardiography. Cats with severely symptomatic hypertrophic cardiomyopathy also had lower peak systolic circumferential strain, in addition to longitudinal and radial strain. Conclusions and relevance Longitudinal and radial deformation may be helpful in the diagnosis of hypertrophic cardiomyopathy. Additionally, the lower circumferential deformation in cats with severe hypertrophic cardiomyopathy may contribute to clinical findings of decompensation, and seems to be related to severe cardiac clinical signs. Indices of multidirectional myocardial deformations by two-dimensional speckle-tracking echocardiography may be useful markers and help to distinguish between cats with hypertrophic cardiomyopathy and healthy cats. Additionally, they may provide more detailed assessment of contractile function in cats with hypertrophic cardiomyopathy.
Complete genome sequence of Thermus brockianus GE-1 reveals key enzymes of xylan/xylose metabolism
Authors: Schäfers Christian , Blank Saskia , Wiebusch Sigrid , Elleuche Skander , Antranikian Garabed 
Published: February 2017

AbstractThermus brockianus strain GE-1 is a thermophilic, Gram-negative, rod-shaped and non-motile bacterium that was isolated from the Geysir geothermal area, Iceland. Like other thermophiles, Thermus species are often used as model organisms to understand the mechanism of action of extremozymes, especially focusing on their heat-activity and thermostability. Genome-specific features of T. brockianus GE-1 and their properties further help to explain processes of the adaption of extremophiles at elevated temperatures. Here we analyze the first whole genome sequence of T. brockianus strain GE-1. Insights of the genome sequence and the methodologies that were applied during de novo assembly and annotation are given in detail. The finished genome shows a phred quality value of QV50. The complete genome size is 2.38 Mb, comprising the chromosome (2,035,182 bp), the megaplasmid pTB1 (342,792 bp) and the smaller plasmid pTB2 (10,299 bp). Gene prediction revealed 2,511 genes in total, including 2,458 protein-encoding genes, 53 RNA and 66 pseudo genes. A unique genomic region on megaplasmid pTB1 was identified encoding key enzymes for xylan depolymerization and xylose metabolism. This is in agreement with the growth experiments in which xylan is utilized as sole source of carbon. Accordingly, we identified sequences encoding the xylanase Xyn10, an endoglucanase, the membrane ABC sugar transporter XylH, the xylose-binding protein XylF, the xylose isomerase XylA catalyzing the first step of xylose metabolism and the xylulokinase XylB, responsible for the second step of xylose metabolism. Our data indicate that an ancestor of T. brockianus obtained the ability to use xylose as alternative carbon source by horizontal gene transfer.
Association between mental health-related stigma and active help-seeking: Systematic review and meta-analysis
Authors: Schnyder Nina , Panczak Radoslaw , Groth Nicola , Schultze-Lutter Frauke 
Published: February 2017

BackgroundMental disorders create high individual and societal costs and burden, partly because help-seeking is often delayed or completely avoided. Stigma related to mental disorders or mental health services is regarded as a main reason for insufficient help-seeking.AimsTo estimate the impact of four stigma types (help-seeking attitudes and personal, self and perceived public stigma) on active help-seeking in the general population.MethodA systematic review of three electronic databases was followed by random effect meta-analyses according to the stigma types.ResultsTwenty-seven studies fulfilled eligibility criteria. Participants' own negative attitudes towards mental health help-seeking (OR = 0.80, 95% CI 0.73–0.88) and their stigmatising attitudes towards people with a mental illness (OR = 0.82, 95% CI 0.69–0.98) were associated with less active help-seeking. Self-stigma showed insignificant association (OR = 0.88, 95% CI 0.76–1.03), whereas perceived public stigma was not associated.ConclusionsPersonal attitudes towards mental illness or help-seeking are associated with active help-seeking for mental problems. Campaigns promoting help-seeking and fighting mental illness-related stigma should target these personal attitudes rather than broad public opinion.
Mitochondrial dynamics in neuronal injury, development and plasticity
Authors: Flippo Kyle H. , Strack Stefan 
Published: February 2017

ABSTRACT
Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering, neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis and intermediate metabolism. Mitochondrial dynamics, a collective term for the processes of mitochondrial fission, fusion and transport, governs mitochondrial function and localization within the cell. Correct balance of mitochondrial dynamics is especially important in neurons as mutations in fission and fusion enzymes cause peripheral neuropathies and impaired development of the nervous system in humans. Regulation of mitochondrial dynamics is partly accomplished through post-translational modification of mitochondrial fission and fusion enzymes, in turn influencing mitochondrial bioenergetics and transport. The importance of post-translational regulation is highlighted by numerous neurodegenerative disorders associated with post-translational modification of the mitochondrial fission enzyme Drp1. Not surprisingly, mitochondrial dynamics also play an important physiological role in the development of the nervous system and synaptic plasticity. Here, we highlight recent findings underlying the mechanisms and regulation of mitochondrial dynamics in relation to neurological disease, as well as the development and plasticity of the nervous system.
Caveolae provide a specialized membrane environment for respiratory syncytial virus assembly
Authors: Ludwig Alexander , Nguyen Tra Huong , Leong Daniel , Ravi Laxmi Iyer , Tan Boon Huan , Sandin Sara , Sugrue Richard J. 
Published: February 2017

ABSTRACT
Respiratory syncytial virus (RSV) is an enveloped virus that assembles into filamentous virus particles on the surface of infected cells. Morphogenesis of RSV is dependent upon cholesterol-rich (lipid raft) membrane microdomains, but the specific role of individual raft molecules in RSV assembly is not well defined. Here, we show that RSV morphogenesis occurs within caveolar membranes and that both caveolin-1 and cavin-1 (also known as PTRF), the two major structural and functional components of caveolae, are actively recruited to and incorporated into the RSV envelope. The recruitment of caveolae occurred just prior to the initiation of RSV filament assembly, and was dependent upon an intact actin network as well as a direct physical interaction between caveolin-1 and the viral G protein. Moreover, cavin-1 protein levels were significantly increased in RSV-infected cells, leading to a virus-induced change in the stoichiometry and biophysical properties of the caveolar coat complex. Our data indicate that RSV exploits caveolae for its assembly, and we propose that the incorporation of caveolae into the virus contributes to defining the biological properties of the RSV envelope.
Strategy of Research Institutes in Construction in Shaping the Research Area
Authors: Kruk Marcin M. 
Published: February 2017

AbstractThe model concept, as presented in this paper, is an original solution created by the author, and can be used as a proposal to build an innovative mechanism to increase the effectiveness of programming and implementation of the development policy, and improve the quality of functioning of a building research institute. The development management system included in this model is a set of actions targeting at the effective use of human and tangible resources, undertaken in a coordinated manner and leading to the achievement of previously established objectives. The market activity of building research institutes is directly or indirectly involved in construction projects, which translates into market mechanisms, such as innovation and competitiveness. In addition, it indicates the participation of a building research institute in the engineering of construction projects as a key to entrepreneurship and implementations.
Problems with Assessing Safety of Vulnerable Road Users Based on Traffic Accident Data
Authors: Olszewski P. , Osińska B. , Szagała P. , Skoczyński P. , Zielińska A. 
Published: February 2017

AbstractThe problem of poor quality of traffic accident data assembled in national databases has been addressed in European project InDeV. Vulnerable road users (pedestrians, cyclists, motorcyclists and moped riders) are especially affected by underreporting of accidents and misreporting of injury severity. Analyses of data from the European CARE database shows differences between countries in accident number trends as well as in fatality and injury rates which are difficult to explain. A survey of InDeV project partners from 7 EU countries helped to identify differences in their countries in accident and injury definitions as well as in reporting and data checking procedures. Measures to improve the quality of accident data are proposed such as including pedestrian falls in accident statistics, precisely defining minimum injury and combining police accident records with hospital data.
Influence of Game Evolution and the Phase of Competition on Temporal Game Structure in High-Level Table Tennis Tournaments
Authors: Leite Jorge Vieira de Mello , Barbieri Fabio Augusto , Miyagi Willian , Malta Elvis de Souza , Zagatto Alessandro Moura 
Published: February 2017

Abstract
The aims of this study were: a) to investigate the game temporal structure in high-level table tennis competitions; b) to verify the influence of game evolution in international competitions from 2009 to 2012 (World Table Tennis Championships and the Olympic Games) on game temporal structure; c) to compare game temporal structure according to the phase of competition. Comparisons between the three international tournaments demonstrated that rally duration decreased significantly (p < 0.05) during the analyzed period (2009-2012), while the rest time increased (p < 0.05) from 2009 to 2011, but decreased (p < 0.05) from 2011 to 2012. In the competition phase analysis, it was found that rally duration decreased (p < 0.05) in the quarterfinals in relation to the semifinals and finals, while the rest time increased (p < 0.05) from the quarterfinals to semifinals and finals. Based on our findings and previous literature, we concluded that the performance level, game evolution and the competition phase influenced the game temporal structure of table tennis, considering longer rest periods adopted by elite athletes in relation to non-elite athletes, the reduction in rally duration and an increase in rest time over the 2009-2012 period and through the competition phases (quarterfinals to finals).
A Multidisciplinary Investigation of the Effects of Competitive State Anxiety on Serve Kinematics in Table Tennis
Authors: Ngo Vuong , Richards Hugh , Kondric Miran 
Published: February 2017

Abstract
Displays of anxiety in table tennis were assessed through subjective (a self-report questionnaire), physiological (heart-rate variability) and kinematic variables. Using a within-group crossover design, 9 university-level table tennis players completed a series of serves under low- and high-anxiety conditions. Anxiety manipulation was achieved through the introduction of a national standard table tennis player, known to the participants, to receive serves in the high-anxiety condition, whilst serves were received by no opponent in the low-anxiety condition. Automated motion capture systems consisting of high-speed 3D motion cameras and analytical software (QUALISYS) determined the subject’s movement kinematics: bat face angle (degrees) and serve routine duration (s). Self-reported state anxiety (MRF-Likert) and heart rate measurements were collected to examine changes between conditions. Contrary to the hypothesis, bat face angles did not change significantly between anxiety conditions (F (1.8) = 2.791, p = 0.133) and movement times were faster in the high-anxiety condition. In light of these findings, research into other facets of movement behaviour must be analysed to gain further understanding of the effects of anxiety on performance, which remain unclear.
Smoking cessation for free: outcomes of a study of three Romanian clinics
Authors: Trofor Antigona Carmen , Man Milena Adina , Marginean Corina , Dumitru Filipeanu , Trofor Letitia 
Published: February 2017

Abstract
In 2007, Romania implemented a national program for smoking cessation, providing medication and counseling, entirely for free. The present study focuses on the results of the program among participating smokers treated in three smoking cessation centers from three main cities of Romania: Iasi, Targu Mures and Cluj.
Telephone interviews of 832 subjects from three databases of the Romanian cessation clinics of Iasi, Cluj and Targu Mures cities were conducted. These interviews were based on a standard Romanian guideline follow-up questionnaire.
At 3 months follow up, abstinence was quite high (53.4%); at 12 months post quit date the study found 18.6% still abstinent subjects. More severely addicted smokers have quit with varenicline and the most difficult category of
patients was represented by heavy smokers with respiratory co-morbidities. 61.5% of smokers and 97.2% of non-smokers were willing to receive relapse prevention counseling. Many subjects achieved a long duration partial abstinence (154 days ± 180 SD abstinence days).
This is the first study in Romanian smoking cessation centers to analyze the long term impact of fully reimbursed smoking cessation, covering three months pharmacotherapy and counseling. Providing smoking cessation for free had a positive long term impact on program participants.
Tensile Behavior and Microstructural Evolution of the Polycrystalline Nickel-Based Superalloy Applied in Turbine Disk
Authors: Shen Xiuli , Dong Shaojing , Chen Zhiying 
Published: February 2017

AbstractIn the present study, the mechanical behaviors and microstructural evolution of the nickel-based superalloy FGH97 at different temperatures and strain rates were studied. First, the tensile tests were conducted at temperatures of 20 °C, 450 °C and 700 °C, respectively, at two specified strain rates of 0.00025 s
Microencapsulation of Oil in Organically Modified Silicate Glass by Sol-Gel Process
Authors: Seok Sang I. , Ahn Bok Y. , Kim Joo H. , Suh Tae S. 
Published: February 2017

AbstractMicroencapsulation provides protection and sustained or controlled release of active core agents. The sol-gel process has opened up a new way for encapsulating oil droplets within an inorganic capsule. Silica microcapsules were prepared in silica precursor-oil mixtures/NH4OH water microemulsion system. In this step, the formation of capsules incorporating oil depended strongly on the type of silica precursor. A spherical silica microsheres were only obtained when oligomer, synthesized by the hydrolysis and co-condensation of equiweight of TEOS (tetraethylorthosilicate) and MTMS (methyltrimethoxysilane), was used as the wall materials. The particles size of silica microcapsules was in the range of 1 ∼ 100 μm, depending on processing parameter such as a shear rate and O/W ratio etc. In controlled release system, the shell porosity is important to give an appropriate permeability, corresponding to the release rate. The pore structure, responsible for permeability, was adjusted by doping alkyl silane, and investigated with nitrogen sorption measurement.
Gas phase deposition of hybrid coatings
Authors: Alcott G.R. , Linden J.L. , Sanden M.C.M. van de 
Published: February 2017

AbstractA new approach for depositing polymer/inorganic hybrid films using gas phase deposition technology has been developed and is the focus of this work. These films combine the high hardness and scratch resistance of inorganic SiO2 films with properties such as flexibility and toughness usually associated with softer polymeric films. The gas phase deposition process eliminates several of the key problems associated with the traditional wet chemical preparation of hybrid materials namely, a reduction in process steps and the elimination of harmful solvents from the process. In addition, gas phase deposition processes generate inherently denser materials then wet chemical processes eliminating post deposition annealing procedures that may damage the substrate. In this study, films are deposited on polycarbonate (PC) and silicon substrates using a novel plasma reactor. In this system, two gas streams, activated by separate plasmas, are combined to form a hybrid thin film.Films are grown from the precursor Tetraethoxysilane (TEOS), 1,2 Bis(trimethylsiloxy)ethane (TMSE) and Tripropylsilane (TPS) evaluated with respect to mechanical, chemical and optical properties, using scratch resistance (Taber abrasion), Methyl Ethyl Ketone (MEK), adhesion and visible transmission measurements. Structural and chemical properties of the deposited films are determined using IR spectroscopic measurements coupled with spectroscopic ellipsometry. The process chemistry and mechanisms are studied using in situ mass spectroscopy, in situ FTIR and spectroscopic ellipsometry.
Large- Scale ab initio Simulations of Fe-doped SrTiO3 Perovskites
Authors: Evarestov R.A. , Eglitis R.I. , Piskunov S. , Kotomin E. A. , Borstel G. 
Published: February 2017

AbstractUsing the Unrestricted Hartree-Fock method and supercells containing up to 160 atoms, we calculated the energy level positions in the gap and atomic geometry for the Fe4+ impurity substituting for a host Ti atom in SrTiO3. In agreement with experiment, the high spin (S=2) state is much lower in energy than the zero-spin state. The energy level positions strongly depend on the asymmetric displacement mode of the six nearest O ions which is a combination of the Jahn-Teller and breathing modes. A considerable covalent bonding between the Fe ion and four nearest O ions takes place.