bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antecedents and effects of individual absorptive capacity: a micro-foundational perspective on open innovation
Authors: Lowik Sandor , Kraaijenbrink Jeroen , Groen Aard J. 
Published: September 2017

PurposeThe paper aims to understand how individuals differ in individual absorptive capacity – their ability to recognize, assimilate, transform and exploit external knowledge. These individual absorptive capacities are a key knowledge management building block for an organization’s open innovation practices. The study examines individual antecedents – human capital, social capital and cognition – and innovation outcomes of individual absorptive capacity.Design/methodology/approachThis is a quantitative study of 147 employees in a single medium-sized Dutch industrial firm. Based on a survey and structural equation modeling, the antecedents’ prior knowledge diversity, network diversity and cognitive style are examined in relation to individual absorptive capacity. Further, the mediating effects of individual absorptive capacity on its antecedents and innovation outcome are investigated.FindingsThe main findings are that prior knowledge diversity, external network diversity and a bisociative cognitive style explain differences in individual absorptive capacity. A bisociative cognitive style appears to be the most important factor. Also, this study finds that individual absorptive capacity mediates between its antecedents and individual innovation performance and is therefore a relevant factor to capture value from external knowledge sources.Research limitations/implicationsThe study extends open innovation theory by exploring individual-level factors that explain the ability to capture value from external knowledge. It suggests that differences in open innovation practices are explained by heterogeneity at the individual level. Further, it explains how individuals’ potentials for open innovation are mediated by their absorptive capacities. These insights enable future researchers to further examine individual-level factors in knowledge management practices and to explore cross-level individual-organizational interactions for open innovation.Practical implicationsThis paper highlights that individuals’ engagements in open innovation practices are explained not only by individuals’ motivations but also by their abilities to absorb external knowledge. Further, it helps managers to design knowledge management practices to promote employees’ absorptive capacities, to improve open innovation processes.Originality/valueThis study investigates the neglected individual-level factors of open innovation practices from a micro-foundational and knowledge management perspective. To our best knowledge, this is the first study to examine individual-level antecedents and outcomes of individual absorptive capacity.
Knowledge translation mechanisms in open innovation: the role of design in R&D projects
Authors: Simeone Luca , Secundo Giustina , Schiuma Giovanni 
Published: September 2017

PurposeThis paper aims to investigate the role of design as a knowledge translation mechanism in R&D-oriented open innovation. In particular, the paper intends to look at how design can be used as a means of knowledge transfer among various stakeholders who speak different languages and have divergent needs and interests in a process where knowledge openly flew across the boundaries of a high number of organizations.Design/methodology/approachThe paper combines the insights from theory with the empirical evidences gathered by adopting an extreme case study approach: the detailed analysis of a case study related to an R&D project funded by the European Commission and aimed to investigate and produce innovative serious games in the area of healthcare. The project gathered a large number of stakeholders and deliberately adopted design to support an open innovation approach.FindingsThe paper provides insights into the use of design outputs such as artifacts, sketches, visual representations or prototypes to translate ideas, theoretical and technical requirements, documents and outputs into formats that can be more easily understood and appreciated by various stakeholders. This supports and favors coordination in open innovation projects where many different stakeholders are engaged in.Research limitations/implicationsAlthough the adoption of an extreme case study approach offers important implications to understand the role of design in R&D-oriented open innovation, the use of a single case study represents the basis both to explore hypothesis and to provide first evidences that need to be further tested with other qualitative and quantitative analysis.Practical implicationsThe paper offers practical implications about how design can help individuals and organizations involved in R&D activities to better communicate and share knowledge among various stakeholders by aligning their different needs, interests and languages along the various phases of their project development.Originality/valueThe originality of the paper lays at the intersection of three different fields: open innovation, knowledge management and design for innovation, thus integrating mature, but so far isolated, research streams. It provides insights for theory building by explaining the use of design as knowledge translational mechanism as well as it informs the practice by highlighting the power of design as a mean to support knowledge flows into open innovation-based R&D projects.
Linking social and spatial networks to viral community phylogenetics reveals subtype‐specific transmission dynamics in African lions
Authors: Fountain‐Jones Nicholas M. , Packer Craig , Troyer Jennifer L. , VanderWaal Kimberly , Robinson Stacie , Jacquot Maude , Craft Meggan E. 
Published: September 2017

AbstractHeterogeneity within pathogen species can have important consequences for how pathogens transmit across landscapes; however, discerning different transmission routes is challenging.Here, we apply both phylodynamic and phylogenetic community ecology techniques to examine the consequences of pathogen heterogeneity on transmission by assessing subtype‐specific transmission pathways in a social carnivore.We use comprehensive social and spatial network data to examine transmission pathways for three subtypes of feline immunodeficiency virus (FIVPle) in African lions (Panthera leo) at multiple scales in the Serengeti National Park, Tanzania. We usedFIVPlemolecular data to examine the role of social organization and lion density in shaping transmission pathways and tested to what extent vertical (i.e., father– and/or mother–offspring relationships) or horizontal (between unrelated individuals) transmission underpinned these patterns for each subtype. Using the same data, we constructed subtype‐specificFIVPleco‐occurrence networks and assessed what combination of social networks, spatial networks or co‐infection best structured theFIVPlenetwork.While social organization (i.e., pride) was an important component ofFIVPletransmission pathways at all scales, we find thatFIVPlesubtypes exhibited different transmission pathways at within‐ and between‐pride scales. A combination of social and spatial networks, coupled with consideration of subtype co‐infection, was likely to be important forFIVPletransmission for the two major subtypes, but the relative contribution of each factor was strongly subtype‐specific.Our study provides evidence that pathogen heterogeneity is important in understanding pathogen transmission, which could have consequences for how endemic pathogens are managed. Furthermore, we demonstrate that community phylogenetic ecology coupled with phylodynamic techniques can reveal insights into the differential evolutionary pressures acting on virus subtypes, which can manifest into landscape‐level effects.
The Effect of Medicaid on Dental Care of Poor Adults: Evidence from the Oregon Health Insurance Experiment
Authors: Baicker Katherine , Allen Heidi L. , Wright Bill J. , Taubman Sarah L. , Finkelstein Amy N. 
Published: September 2017

ObjectiveTo evaluate the effect of Medicaid coverage on dental care outcomes, a major health concern for low‐income populations.Data SourcesPrimary and secondary data on health care use and outcomes for participants in Oregon's 2008 Medicaid lottery.Study DesignWe used the lottery's random selection to gauge the causal effects of Medicaid on dental care needs, medication, and emergency department visits for dental care.Data CollectionData were collected for lottery participants over 2 years, including mail surveys (N = 23,777) and in‐person questionnaires (N = 12,229). Emergency department (ED) records were matched to lottery participants in Portland (N = 24,646).Principal FindingsMedicaid coverage significantly reduced the share of respondents who reported needing dental care (−9.8 percentage points, p < .001) or having unmet dental care needs (−13.5 percentage points, p < 0.001). Medicaid doubled the share visiting the ED for dental care (+2.6 percentage points, p = .003) and the use of anti‐infective medications often prescribed for dental care, but it had no detectable effect on uncovered dental care or out‐of‐pocket spending.ConclusionsExpansion of Medicaid covering emergency dental care substantially reduced unmet need for dental care, increasing ED dental visits and medication use, while not changing patient use of uncovered dental services.
The Role of Forensic Botany in Solving a Case: Scientific Evidence on the Falsification of a Crime Scene
Authors: Aquila Isabella , Gratteri Santo , Sacco Matteo A. , Ricci Pietrantonio 
Published: September 2017

AbstractForensic botany can provide useful information for pathologists, particularly on crime scene investigation. We report the case of a man who arrived at the hospital and died shortly afterward. The body showed widespread electrical lesions. The statements of his brother and wife about the incident aroused a large amount of suspicion in the investigators. A crime scene investigation was carried out, along with a botanical morphological survey on small vegetations found on the corpse. An autopsy was also performed. Botanical analysis showed some samples of Xanthium spinosum, thus leading to the discovery of the falsification of the crime scene although the location of the true crime scene remained a mystery. The botanical analysis, along with circumstantial data and autopsy findings, led to the discovery of the real crime scene and became crucial as part of the legal evidence regarding the falsity of the statements made to investigators.
The Biological Effects of Kambo: Is There a Relationship Between its Administration and Sudden Death?
Authors: Aquila Isabella , Gratteri Santo , Sacco Matteo A. , Fineschi Vittorio , Magi Simona , Castaldo Pasqualina , Viscomi Graziella , Amoroso Salvatore , Ricci Pietrantonio 
Published: September 2017

AbstractKambo is a substance obtained from the skin secretions of a frog, Phyllomedusa bicolor, popular in the Amazon region, which is administered via the transdermal route. We report a case of 42‐year‐old man found dead in his house. Near the corpse, a plastic box labeled as “Kambo sticks” was found. The man was a chronic consumer of Kambo and no previous pathology or genetic disease emerged in clinical history from the declaration of his general practitioner. Autopsy investigations and toxicological analysis were performed. The histopathological examination showed left ventricular hypertrophy. Toxicological screening was negative for ethanol and other drugs. Phyllocaerulein, phyllokinin, and deltorphin A were isolated from the Kambo sticks but, only deltorphin A was detected in blood sample. We describe the first forensic case of death associated with Kambo administration. We attempt to explain how its use could be related to the cause of sudden death in this case.
Combined Effect of Polyphenol‐Chitosan Coating and Irradiation on the Microbial and Sensory Quality of Carp Fillets
Authors: Zhang Qiu Qin , Rui Xin , Guo Yi , He Min , Xu Xing Lian , Dong Ming Sheng 
Published: September 2017

AbstractIrradiation can extend the shelf‐life of fish, but it may cause unacceptable change on quality. Since rose polyphenols have high antioxidant and antibacterial activities, this study evaluated the combined effect of polyphenol‐chitosan coatings and irradiation (3 kGy) on the microbial and sensory qualities of carp fillets during storage at 4 °C. A dose of 3 kGy irradiation reduced the initial total viable counts (TVC) and psychrophiles, and increased the initial b* and thiobarbituric acid reactive substance (TBARS) values. During storage, TBARS, TVC and psychrophiles of nonirradiated samples increased faster and were higher than those irradiated. Regardless of irradiation treatment, samples coated with chitosan containing rose polyphenols had lower TBARS, pH and bacteria than that in no coating or chitosan coating batches. Carp treated with combined treatment could preserve an acceptable sensory quality at the end of storage. The result indicated that polyphenol‐chitosan coating combined with irradiation can maintain fish quality by preventing bacterial growth, oxidation, and changes in color and sensory acceptability.
Abnormal gray matter volume and impulsivity in young adults with Internet gaming disorder
Authors: Lee Deokjong , Namkoong Kee , Lee Junghan , Jung Young‐Chul 
Published: September 2017

AbstractReduced executive control is one of the central components of model on the development and maintenance of Internet gaming disorder (IGD). Among the various executive control problems, high impulsivity has consistently been associated with IGD. We performed voxel‐based morphometric analysis with diffeomorphic anatomical registration by using an exponentiated Lie algebra algorithm (DARTEL) to investigate the relationship of gray matter abnormalities to impulsivity in IGD. Thirty‐one young male adults whose excessive Internet gaming began in early adolescence, and 30 age‐matched male healthy controls were examined. IGD subjects showed smaller gray matter volume (GMV) in brain regions implicated in executive control, such as the anterior cingulate cortex and the supplementary motor area. The GMVs in the anterior cingulate cortex and the supplementary motor area were negatively correlated with self‐reporting scales of impulsiveness. IGD subjects also exhibited smaller GMV in lateral prefrontal and parietal cortices comprising the left ventrolateral prefrontal cortex and the left inferior parietal lobule when compared with healthy controls. The GMVs in the left ventrolateral prefrontal cortex were negatively correlated with lifetime usage of Internet gaming. These findings suggest that gray matter abnormalities in areas related to executive control may contribute to high impulsivity of young adults with IGD. Furthermore, alterations in the prefrontal cortex were related with long‐term excessive Internet gaming during adolescence.
The future of the international drug control system and national drug prohibitions
Authors: Hall Wayne 
Published: September 2017

AbstractA major impediment to any nation abandoning the policy of drug prohibition has been the fact that international drug treaties to which the majority of United Nations (UN) member states are signatory prohibit the non‐medical use of amphetamines, cannabis, cocaine and heroin. The future of these treaties is now uncertain because of decisions by Uruguay, eight US states and Canada to legalize cannabis use. This paper: (1) provides a brief account of the international drug control treaties; (2) outlines the major criticisms of the treaties; (3) analyses critically proposals for treaty reform; and (4) provides a personal view on policies that nation states could adopt to minimize the harms from the use of cannabis, party drugs and hallucinogens, opioids, stimulants and new psychoactive substances. It is argued that: a major risk of cannabis legalization in the United States is promotion of heavy use and increased harm by a weakly regulated industry; some cautious national experiments with the regulation of party drugs and hallucinogens would be informative; a strong case remains for prohibiting the nonmedical use of opioids while mitigating the adverse effects that this policy has on opioid‐dependent people; stimulant legalization will probably increase problem use but prohibition is difficult to enforce, highlighting the urgency of finding better ways to reduce demand for these drugs and respond to problem users; and that it is unclear what the best approach is to reducing possible harms that may arise from the use of new psychoactive substances.
Review article: transient receptor potential channels as possible therapeutic targets in irritable bowel syndrome
Authors: Beckers A. B. , Weerts Z. Z. R. M. , Helyes Z. , Masclee A. A. M. , Keszthelyi D. 
Published: September 2017

SummaryBackgroundAbdominal pain in irritable bowel syndrome (IBS) remains challenging to treat effectively. Researchers have attempted to elucidate visceral nociceptive processes in order to guide treatment development. Transient receptor potential (TRP) channels have been implied in the generation (TRPV1, TRPV4, TRPA1) and inhibition (TRPM8) of visceral pain signals. Pathological changes in their functioning have been demonstrated in inflammatory conditions, and appear to be present in IBS as well.AimTo provide a comprehensive review of the current literature on TRP channels involved in visceral nociception. In particular, we emphasise the clinical implications of these nociceptors in the treatment of IBS.MethodsEvidence to support this review was obtained from an electronic database search via PubMed using the search terms “visceral nociception,” “visceral hypersensitivity,” “irritable bowel syndrome” and “transient receptor potential channels.” After screening the abstracts the articles deemed relevant were cross‐referenced for additional manuscripts.ResultsRecent studies have resulted in significant advances in our understanding of TRP channel mediated visceral nociception. The diversity of TRP channel sensitization pathways is increasingly recognised. Endogenous TRP agonists, including poly‐unsaturated fatty acid metabolites and hydrogen sulphide, have been implied in augmented visceral pain generation in IBS. New potential targets for treatment development have been identified (TRPA1 and TRPV4,) and alternative means of affecting TRP channel signalling (partial antagonists, downstream targeting and RNA‐based therapy) are currently being explored.ConclusionsThe improved understanding of mechanisms involved in visceral nociception provides a solid basis for the development of new treatment strategies for abdominal pain in IBS.
Identification of lactic acid bacteria in the feces of dairy cows fed whole crop maize silage to assess the survival of silage bacteria in the gut
Authors: Han Hongyan , Wang Chao , Li Yanbing , Yu Zhu , Xu Qingfang , Li Guangpeng , Minh Tang Thuy , Nishino Naoki 
Published: September 2017

AbstractIn order to assess the survival of lactic acid bacteria (LAB) in whole crop maize silage in the gut of dairy cows, one representative silage sample and three different feces samples were collected from dairy cows on three dairy farms in Hua Bei, China and three dairy farms in Kyushu, Japan. The composition of the bacterial community was examined by denaturing gradient gel electrophoresis and quantitative polymerase chain reaction. Lactobacillus acetotolerans was detected in all bunker‐made maize silage samples, regardless of the dairy farm or sampling region from which they were sourced. A total of eight LAB species were detected in the maize silage samples, of which three (L. acetotolerans, L. pontis and L. casei) appeared to survive digestion. The populations of L. acetotolerans in silage and feces were 106–7 and 103–4 copies/g, respectively, indicating that, even for the LAB species showing potential survival in the gut, competition in this niche may be harsh and the population may substantially decrease during the digestion process. It may be difficult for silage LAB to survive in the gut of silage‐fed dairy cows, because marked decrease in population can take place during the digestion process, even for surviving species.
First progress report on the Japan Endoscopy Database project
Authors: Kodashima Shinya , Tanaka Kiyohito , Matsuda Koji , Fujishiro Mitsuhiro , Saito Yutaka , Ohtsuka Kazuo , Oda Ichiro , Katada Chikatoshi , Kato Masayuki , Kida Mitsuhiro , Kobayashi Kiyonori , Hoteya Shu , Horimatsu Takahiro , Matsuda Takahisa , Muto Manabu , Yamamoto Hironori , Ryozawa Shomei , Iwakiri Ryuichi , Kutsumi Hiromu , Miyata Hiroaki , Kato Mototsugu , Haruma Ken , Fujimoto Kazuma , Uemura Naomi , Kaminishi Michio , Tajiri Hisao 
Published: September 2017

Background and AimThe Japan Endoscopy Database (JED) Project was started to develop the world's largest endoscopic database, capture the actual performance of endoscopic practice, and standardize the terminology and fundamental items needed for a clinical and research registry. This paper presents a progress report on the first phase of this project undertaken at eight endoscopic centers in Japan.MethodsThe list of data items to be collected was drafted by the MSED‐J (Minimal Standard Endoscopic Database) subcommittee. These items were aggregated offline by integrating data from two endoscopic filing systems between July 2015 and December 2015. The study population included all patients who underwent esophagogastroduodenoscopy or colonoscopy at all eight centers, patients who underwent enteroscopy at five of the eight centers, and patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) at four of the eight centers.ResultsData collected in this phase included 61 070 endoscopic procedures, of which 40 475 were esophagogastroduodenoscopies, 215 were enteroscopies, 19 204 were colonoscopies, and 1176 were ERCPs. Frequencies of complications were 0.68% for esophagogastroduodenoscopy, 0% for enteroscopy, 0.43% for colonoscopy, and 13.34% for ERCP. In addition, we obtained various data including Helicobacter pylori infection status, past history of endoscopy in patients who underwent enteroscopy or colonoscopy, and degree of difficulty of ERCP, although the frequencies of reporting were sometimes low, with some items <20%.ConclusionResults of the first phase suggest that the JED project can provide vast quantities of useful data about endoscopic procedures.
Post‐socialist transition and intergenerational educational mobility in Kyrgyzstan
Authors: Brück Tilman , Esenaliev Damir 
Published: September 2017

AbstractWe investigate long‐term trends in intergenerational educational mobility in a lower middle‐income transition economy. We draw on evidence from Kyrgyzstan using data from three household surveys collected in 1993, 1998 and 2011. We find that Kyrgyzstan, like Eastern European middle‐income transition economies, maintained high educational mobility, comparable to levels during the Soviet era. However, we find that the younger cohorts, exposed to the transition during their school years, experienced a rapid decline in educational mobility. We also document that gender differences in schooling and educational mobility, found among older‐aged individuals, disappeared in the younger cohorts.