bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety concerns associated with second-generation antipsychotic long-acting injection treatment. A systematic update
Authors: Gentile Salvatore 
Published: June 2017

Abstract

Background
It has been recently suggested that second-generation antipsychotic long-acting injection (SGA-LAIs) are underutilized in clinical practice, despite that their costs significantly impact on national health system budgets. Hence, an updated analysis of safety data shown by SGA-LAIs may contribute to clarify their role in clinical practice.

Materials and methods
English-language, peer-reviewed articles reporting updated, primary findings on the SGA-LAI safety were identified (updated through an electronic search of five databases – PubMed, EMBASE, PsycInfo, DARE and the Cochrane Library).

Results
The articles reviewed suggest that the most frequent treatment emergent adverse events (TEAEs) associated with aripiprazole long-acting injection (ARI-LAI) are psychotic symptoms, extrapyramidal symptoms (EPS) and weight gain. Data on olanzapine long-acting injection (OLA-LAI)-associated TEAEs highlight the risk of psychosis, metabolic disturbances and hyperprolactinemia. Four-hundred and forty cases of post-injection delirium/sedation syndrome (PDSS) have also been recorded. Although not reported in reviewed studies, the risk of impulse-control problem and drug reaction with eosinophilia and systemic symptoms (DRESS) ARI- and OLA-associated, respectively, must not be underestimated. With regards paliperidone palmitate 1-month formulation (PP1), the high incidence of clinically relevant weight gain and hyperprolactinemia are both findings of concern. Reviewed data also confirm that the leading cause of death in risperidone long-acting injection (RIS-LAI) clinical trials is suicide. The new 3-month paliperidone palmitate formulation, risperidone sustained release 1-month formulation (RIS-SR1), aripiprazole lauroxil (ARI-LXL) are still lacking exhaustive safety data.

Conclusion
The risk of specific TEAEs associated with all SGA-LAIs confirms SGA-LAIs do not offer advantages in safety compared with FGA-LAIs or oral antipsychotics and, especially, in early-phase schizophrenia patients. Implementing non pharmacological intervention and strategies can be effective for people with schizophrenia and bipolar disorder who adhere poorly to medication regimens.
Advances in Studies on Hepatitis E Virus
Authors: Zhang Weiying 
Published: June 2017

Abstract
Hepatitis E virus (HEV) is transmitted mainly through food and water sources. HEV is a major public health problem faced by developing countries. HEV causes large outbreaks of hepatitis E (HE) or acute sporadic infection. HEV can also lead to chronic infection. HEV mainly affects the young, middle-aged people, and pregnant women, who especially display high rates of infection. This study reviews HE while considering its biological characteristics, clinical symptoms, epidemic characteristics, vaccine, and detection methods.
Clinical, biochemical and genetic features with nonclassical 21-hydroxylase deficiency and final height
Authors: Savaş-Erdeve Şenay , Çetinkaya Semra , Abalı Zehra Yavaş , Poyrazoğlu Şükran , Baş Firdevs , Berberoğlu Merih , Sıklar Zeynep , Korkmaz Özlem , Buluş Derya , Akbaş Emine Demet , Güran Tülay , Böber Ece , Akın Onur , Yılmaz Gülay Can , Aycan Zehra 
Published: June 2017

AbstractBackground:The clinical, laboratory, genetic properties and final height of a large cohort of patients with nonclassical 21-hydroxylase deficiency (NC21OHD) in Turkey were analyzed.Methods:This multicenter, nationwide web-based study collected data.Results:The mean age was 9.79±4.35 years (229 girls, 29 boys). The most common symptoms were premature pubarche (54.6%) and hirsutism (28.6%). The peak cortisol was found below 18 μg/dL in three (15.45%) patients. A mutation was detected in theConclusions:The final height of the patients who were treated during childhood was found to be shorter than the final height of patients during the adolescent period.
Das deutsche Kartellrecht – Einführung und Wiederholung
Authors: Küster Stefan 
Published: June 2017

AbstractDer Beitrag richtet sich an Studenten, die sich im Schwerpunkt oder aus Interesse mit dem Kartellrecht beschäftigen. Er will den Einstieg in die Materie erleichtern und auch dem Wiederholenden noch einmal die wichtigsten Denkbrücken zur Lösung eines kartellrechtlichen Falles nach dem GWB aufzeigen. Dabei orientiert er sich nach den möglichen Einstiegsmöglichkeiten in eine Klausur und erläutert Schritt für Schritt die wesentlichen Tatbestandsmerkmale und Probleme.
Pragmatics of emotionality in discourse processing: prolegomena to ideology shaping engines
Authors: Pinich Iryna 
Published: June 2017

Abstract
Employing the theory of Intentionality the paper argues ubiquity and continuity of the pragmatic category of emotional intentionality in generating and promulgating ideologies via the literary works of contemporaries. The paper offers explanations of the nature of emotionality in the structure of emotional ecosystems and highlights the correlation of dominant emotional communities and dissemination of ideologies.
When phonetics matters: creation and perception of female images in song folklore
Authors: Stashko Halyna 
Published: June 2017

Abstract
This paper presents a stylistic analysis of female images in American song folklore in order to examine how sound symbolic language elements contribute to the construction of verbal images. The results obtained show the link between sound and meaning and how such phonetic means of stylistics as assonance, alliteration, and onomatopoeia function to reinforce the meanings of words or to set the mood typical of the characters. Their synergy helps create and interpret female images and provides relevant atmosphere and background to them in folk song texts.
Assessing soundscape: Comparison between in situ and laboratory methodologies
Authors: Hermida Cadena Luis Fernando , Lobo Soares Antonio Carlos , Pavón Ignacio , Coelho Luis Bento 
Published: June 2017

Abstract
The assessment of soundscape implies an interdisciplinary approach, where objective and subjective aspects are considered. For the subjective evaluation, in situ and laboratory methodologies are usually followed. Local observations allow the collection of information on the influence of different stimuli present in the environment, whereas laboratory tests present a determined quantity of controlled stimuli to the evaluator. The purpose of this work is to compare results from the different methodologies in order to understand their strengths and their weaknesses. Three urban parks in the city of Lisbon, Portugal, were evaluated. Fragments of binaural sound recordings collected in the parks were used in laboratory tests to compare with the responses in situ and of expert and nonexpert listeners. Statistically significant differences were found in several of the perceptual attributes under observation, which led to variation in the results of the main model’s components. The sound environments were found to be more pleasant and uneventful in situ than in the laboratory, a phenomenon possibly due to the influence of other stimuli such as visual in the process of assessment. The in situ tests allow a systemic and holistic evaluation of the environment under study,whereas the laboratory tests allow a specific and tightly targeted analysis of different component sound events. Therefore, the two methodologies can be useful in soundscape assessment depending on the specific application and needs. No differences were found in the assessment made by either experts or nonexperts.
Assessment of highway infrastructure projects in Latin America and Perú from the competences point of view
Authors: Zevallos Germán Gallardo , Machicao Tatiana , Romero María Josée Martínez-Echevarría 
Published: June 2017

Abstract
It is stressed that Latin America and Perú should become more competitive. Under the actual development scenarios, attention to competences of programme managers and project managers related to public transportation infrastructure projects has risen substantially.
An inefficient bureaucratic system is related with deficiencies of people skills and competences. On the other hand, an excellent system demands quality of the system and quality of people working in it.
Thus, it is important to have excellence in administration and excellent administrators in the public sector. Three main lacking elements have been identified: i) lack of good education; ii) absence of fair salaries in the public sector; and iii) lack of incentives. Many misconceptions and disputed consequences have been observed and analyzed. It is clear that there is lack of competence among infrastructure transport project managers and teams, which causes trouble with the main goal of Peru getting benefits from these investments and achieving sustainable development. Furthermore, the right way to achieve these benefits is through a new model of education for project managers and programme managers in Perú. This education should be based more on competences than on qualifications. Thus, the International Project Management Association (IPMA) competence baseline, which is the standard that best fits to these needs, needs to be implemented to achieve the real contribution and benefits of these projects to society.
Dry periods impact on the surface water quality
Authors: Duca Gheorghe , Xiao Hong , Nedealcov Maria , Ivanov Violeta , Tarita Anatol 
Published: June 2017

Abstract
Current changes of the environment represent the major threats to the sustainable development and are one of the biggest problems, with negative consequences on the national economy. The accelerated pace of these changes is shareholder and by the manifestation of extreme events, which in recent years become more intense and frequent. The drought events frequent manifestation over the Republic of Moldova territory, in the context of climate change, requires a scientific monitoring adjusted.
The dry period’s manifestation is greatly conditioned by increasing daytime temperatures (above 25°C) and the lower relative humidity (below 30%). At present, on the background of climate change, there is an increase of dry days. Over the Republic of Moldova territory, their occurrence during growth and development of crops particularly damaging role in obtaining low yields. Meanwhile, prolonged dry periods, may possibly cause fires, at the same time can determine lands’ irrigation and surface water quality.
In this context, there is a need to estimate the evaporation’s spatial and temporal variability, the number of dry days and their correlation to Dry Periods Index (Izu), the index developed at regional level.
Obesity in children - a problem of the contemporary civilization
Authors: Kupczak-Wiśniowska Bogusława , Borgosz Jolanta , Podsiadło Beata , Serzysko Bogusława , Jędrkiewicz Elżbieta 
Published: June 2017

AbstractIntroduction.In the recent thirty years obesity has become one of the most serious and still increasing health problems among children and adults in the world. Scientific magazines inform about world obesity epidemic. Lack of physical activity, excessive energy supply compared to needs of organism, as well as bad eating habits, have made obesity a civilization disease. Excess weight and obesity lead to premature atherosclerosis development and consequently, to other cardiovascular diseases such as arterial hypertension, thrombosis, cardiac insufficiency, hyperlipemia.Aim.The aim of the thesis is to present, on the basis of literature, the most important factors which can lead to obesity in children.Conclusions.Among the most important aspects which can lead to obesity in children the following factors can be mentioned:genetic factors - it is probable that mutations within many genes connected with energy efficiency regulation of an organism are responsible for the genetic tendency to being obeseenvironmental factors - there is another fact that together with technological development, the level of physical activity has decreasedpsychological factors, like stress, fear, failures at school, family and peer conflicts have become the reasons for compulsive behaviour which lead to excessive consumption of highly processed foodsObesity results in lowering the quality of life in a significant way.
Trust in the doctor-patient relationship in the light of the latest research
Authors: Pawlikowska-Łagód Katarzyna , Sak Jarosław 
Published: June 2017

Abstract

Introduction. Trusting the medical staff, especially the doctor is a fundamental part of the success of the treatment process. Appropriate level of trust in a doctor-patient relationship affects the patient’s compliance with the physician’s recommendations and motivates patient to fight the disease. Over the last few years, numerous studies have been conducted on the level of trust in medical staff, especially doctors.

Aim. The aim of this study is to present reports on research on patients’ trust in doctors of various specialties. The work will be done in the form of analysis of literature, including statistical data, scientific papers and professional literature.

Results. Discussed topic has been raised in various countries, such as Poland, the United Kingdom, Nigeria, China. Presented overview of the work of research shows that the level of trust in the doctors of various specialties is unequal.

Conclusions. It is extremely important that the analyzes are conducted on the topic, and as a consequence some appropriate measures to strengthen relationships and trust in doctors should be taken.
First aid at the scene in the opinion of the members of Warsaw medical rescue teams
Authors: Binkowska Aneta , Kamecki Artur 
Published: June 2017

Abstract

Introduction. The ability to provide first aid should be one of the basic skills of each of us.

Aim. The aim of the study was to learn the opinion of the members of Medical Rescue Teams (MRT) of the “Meditrans” Provincial Ambulance and Sanitary Transport Service (PA and STS “Meditrans”) in Warsaw on how people react in real situations threatening life or health of the injured person.

Material and methods. The study was conducted in the third quarter of 2015 on 335 members of medical rescue teams, including 77 women and 258 men, who provided medical services in the “Meditrans” Provincial Ambulance and Sanitary Transport Service MRT in Warsaw. The research tool was an anonymous questionnaire survey of own design, which consisted of 12 questions: closed, half open and one open question.

Results. The majority of respondents have encountered instances of first aid provision, but respondents assessed the frequency of such situations as low. Among the largest group of witnesses providing first aid there are the elderly and youth, who are subjected to various forms of education related to first aid provision.

Conclusions. Only continuous education and in particular, practical trainings will help people to overcome the barrier of their limitations in order to help others.
The quality of life perception by gender and place of residence during assessment of thrombocytopenia impact on patients’ daily activities using TSIDAV vignette
Authors: Szkultecka-Dębek Monika , Drozd Mariola , Bem Marta 
Published: June 2017

AbstractIntroduction.The term “quality of life” has been present in the literature for a long time now. It was created in the middle of the last century in Western Europe and from the societal perspective the term initially defined the level of material life, gradually being expanded to other aspects of human life, like happiness, education, broadly defined individual freedom and health.Aim.To analyze differences by gender and place of residence in perception of quality of life based on data from the assessment of thrombocytopenia impact on daily activities using TSIDAV vignette among Polish patients.Material and methods.We assessed the impact of thrombocytopenia symptoms on patients’ daily activities using TSIDAV vignette. We wanted to understand the reason for different perception of symptoms and why visible symptoms are perceived as worse by women in comparison to men. We analyzed the groups by age and place of residence.Results.Within 48 collected questionnaires, 31 were provided by women and 17 by men. As many as 29% of men declared the biggest impact on daily activities due to petechiae and easy bruising. The same symptoms were assessed as having significant impact on daily activities by 68% and 65% of women respectively. The results in relation to the two symptoms were similar in terms of impact: both men and women assessed it as high impact, however in general, a lower proportion of men identified this as an issue. As many as 53% of the pre-menopausal women declared the thrombocytopenia impact on daily activities as very high. Similar results were observed in the male group. Those before retirement age assessed disease symptoms as very high in comparison to the group of older patients. No significant differences in relation to place of residence were observed. During literature research we found that depending on patients’ gender, the perception of the impact of disease on patients quality of life may often differ.Conclusions.We found out that the perception of disease symptoms impact on quality of life is different by women and men. That may be the result of different factors such as the influence of social roles determined for each sex. At the same time, the perception of the impact of thrombocytopenia symptoms on daily activity almost does not depend on age or place of residence of neither women nor men.
Emergence of Commodity Derivatives as Defensive Instrument in Portfolio Risk Hedging: A Case of Indian Commodity Markets
Authors: Singhal Shelly 
Published: June 2017

Abstract
This paper empirically examines whether commodity derivatives can be used as an alternative investment asset in India where commodity markets are at emerging state and provides the same diversification benefit as they provide in developed commodity markets. In India only commodity futures are prevalent so various commodity indices representing various sectors has been used in the study. Diversification aspect of commodity derivatives has been tested initially by using correlation analysis. Compounded Daily Growth rate and Relative Standard deviation has been used as a measure of calculating risk and return of daily data of SENSEX, BOND and four Commodity Indices (MCX Comdex, MCX AGRI, MCX Metal, MCX Energy). Markowitz Efficient Frontier theory has been used to calculate portfolio risk return and Sharpe risk adjusted ratio has been used to evaluate the various portfolios. Optimal portfolio has been obtained for the combination of equity, bond and commodity and overall results of the study indicate that an investor who is risk averse will prefer to invest in combination of SENSEX, BOND & MCX Energy whereas an investor who gets utility by taking more risk for more returns will prefer to invest in combination of SENSEX, BOND & MCX Metal. Investor having inclination towards moderate risk return would tend to invest in MCX AGRI along with SENSEX and BOND.
On the Certain Topological Indices of Titania Nanotube TiO2[m, n]
Authors: Javaid M. , Liu Jia-Bao , Rehman M. A. , Wang Shaohui 
Published: June 2017

Abstract
A numeric quantity that characterises the whole structure of a molecular graph is called the topological index that predicts the physical features, chemical reactivities, and boiling activities of the involved chemical compound in the molecular graph. In this article, we give new mathematical expressions for the multiple Zagreb indices, the generalised Zagreb index, the fourth version of atom-bond connectivity (ABC4) index, and the fifth version of geometric-arithmetic (GA5) index of TiO2[m, n]. In addition, we compute the latest developed topological index called by Sanskruti index. At the end, a comparison is also included to estimate the efficiency of the computed indices. Our results extended some known conclusions.
Stability and Metastability of Trapless Bose-Einstein Condensates and Quantum Liquids
Authors: Zloshchastiev Konstantin G. 
Published: June 2017

AbstractVarious kinds of Bose-Einstein condensates are considered, which evolve without any geometric constraints or external trap potentials including gravitational. For studies of their collective oscillations and stability, including the metastability and macroscopic tunneling phenomena, both the variational approach and the Vakhitov-Kolokolov (VK) criterion are employed; calculations are done for condensates of an arbitrary spatial dimension. It is determined that that the trapless condensate described by the logarithmic wave equation is essentially stable, regardless of its dimensionality, while the trapless condensates described by wave equations of a polynomial type with respect to the wavefunction, such as the Gross-Pitaevskii (cubic), cubic-quintic, and so on, are at best metastable. This means that trapless “polynomial” condensates are unstable against spontaneous delocalization caused by fluctuations of their width, density and energy, leading to a finite lifetime.
Conversation with Ted Jackson, Carleton University
Authors: Jackson Edward T. , Khanenko-Friesen Natalia 
Published: June 2017

In the Exchanges, we present conversations with scholars and practitioners of community engagement, responses to previously published material, and other reflections on various aspects of community-engaged scholarship meant to provoke further dialogue and discussion. We invite our readers to offer in this section their own thoughts and ideas on the meanings and understandings of engaged scholarship, as practiced in local or faraway communities, diverse cultural settings, and various disciplinary contexts. We especially welcome community-based scholars’ views and opinions on their collaboration with university-based partners in particular and on engaged scholarship in general. Below, Natalia Khanenko-Friesen talks to Edward “Ted” Jackson about his work and his views on engaged scholarship in Canada. Dr. Jackson is a senior research fellow of Carleton Centre for Community Innovation and adjust research professor in Public Policy and Administration, International Affairs and African Studies at Carleton University, Ottawa. Ted Jackson served as a the conference convenor for C2UExpo, held at the Carleton in May 2015.
Implicit Weight Bias in Children Age 9 to 11 Years
Authors: Skinner Asheley Cockrell , Payne Keith , Perrin Andrew J. , Panter Abigail T. , Howard Janna B. , Bardone-Cone Anna , Bulik Cynthia M. , Steiner Michael J. , Perrin Eliana M. 
Published: June 2017

OBJECTIVES:
Assess implicit weight bias in children 9 to 11 years old.

METHODS:
Implicit weight bias was measured in children ages 9 to 11 (N = 114) by using the Affect Misattribution Procedure. Participants were shown a test image of a child for 350 milliseconds followed by a meaningless fractal (200 milliseconds), and then they were asked to rate the fractal image as “good” or “bad.” We used 9 image pairs matched on age, race, sex, and activity but differing by weight of the child. Implicit bias was the difference between positive ratings for fractals preceded by an image of a healthy-weight child and positive ratings for fractals preceded by an image of an overweight child.

RESULTS:
On average, 64% of abstract fractals shown after pictures of healthy-weight children were rated as “good,” compared with 59% of those shown after pictures of overweight children, reflecting an overall implicit bias rate of 5.4% against overweight children (P &lt; .001). Healthy-weight participants showed greater implicit bias than over- and underweight participants (7.9%, 1.4%, and 0.3% respectively; P = .049).

CONCLUSIONS:
Implicit bias toward overweight individuals is evident in children aged 9 to 11 years with a magnitude of implicit bias (5.4%) similar to that in studies of implicit racial bias among adults.