bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gallstones in childhood: etiology, clinical features, and prognosis
Authors: Serdaroglu Filiz , Koca Yavuz S. , Saltik Fatma , Koca Tugba , Dereci Selim , Akcam Mustafa , Akcam Fusun Z. 
Published: August 2016

AimThe aim of this study was to determine demographic and clinical features in children diagnosed with gallstones, risk factors for gallstone formation, the effectiveness of ursodeoxycholic acid therapy, and the course of the disease.Materials and methodsPatients aged 0–18 years were followed up for at least 6 months after the diagnosis of gallstones with ultrasonography and were evaluated retrospectively. Patients were evaluated with respect to age, sex, presenting symptoms, BMI, facilitating factors, accompanying diseases, family history of gallstones, history of ceftriaxone use, laboratory tests, ultrasonography findings and follow-up, and therapeutic approaches and results.ResultsThe study was completed with 70 patients. Thirty-nine (55.7%) patients were females. The mean age of the patients was 9.3±5.29 (0.3–18) years. The mean age among females was statistically significantly higher than that among males (P=0.007).No risk factor for stone formation was encountered in 50% of cases, whereas a family history of gallstones was present in 17.1%. Use of ceftriaxone was present in 8.6% of cases, total parenteral nutrition in 10%, obesity in 5.7%, hereditary spherocytosis in 4.3%, and Down’s syndrome in 4.3%. The probability of dissolution of stones was 3.6 times higher in patients with stone sizes up to 5 mm [odds ratio (OR): 3.65,P=0.020], 3.9 times higher in those aged younger than 2 years (OR: 3.92,P=0.021), and 13.9 times higher in those with a single stone (OR: 13.97,P=0.003).ConclusionOur findings show that unknown causes are still prevalent in stone formation and that ursodeoxycholic acid exerts no effect on stone dissolution; however, diagnosis at younger than 2 years of age, a single stone, and small size of stone are factors affecting dissolution.
Correction of Iron Deficiency Anemia With Intravenous Iron Sucrose in Children With Inflammatory Bowel Disease
Authors: Danko Istvan , Weidkamp Marcy 
Published: August 2016

ABSTRACTObjectives:Iron deficiency anemia (IDA) is common in children with inflammatory bowel disease (IBD) affecting their cognitive development and school performance. Oral iron supplementation has serious limitations including poor adherence and iron malabsorption related to chronic inflammation. Our objective was to evaluate the feasibility of periodic intravenous (IV) iron treatments for correction of IDA in children with IBD.Methods:This prospective study was conducted in 24 children with IBD treated with infliximab (IFX). Participants received 3 mg/kg (maximum 200 mg) IV iron sucrose (IS) after IFX treatments if they were iron deficient according to criteria: ferritin <30 ng/mL or transferrin saturation (TSAT) <20% with normal C‐reactive protein (CRP), or ferritin <100 ng/mL and TSAT <20% with elevated CRP. They continued to receive IV IS with each IFX treatment until 2 consecutive laboratories showed no evidence of iron deficiency. Hematology and iron indices obtained during the study were compared with historic controls from the same patients.Results:Mean ferritin, TSAT, and hemoglobin (Hb) (±SE) rose from 21.9 (±3.2) to 48.8 (±6.3) ng/mL (P = 0.0004), 13.2 (±1.8) to 23.6 (±2.6)%, (P = 0.0009) and 11.4 (±0.3) to 12.7 (±0.3) g/dL, (P = 0.006) respectively. The proportion of patients with normal mean ferritin, TSAT, and Hb rose from 33% to 75% (P = 0.002), 21% to 63% (P = 0.006), and 25% to 79% (P = 0.0002), respectively. There were no adverse reactions.Conclusions:Periodic IV IS is safe and effective for routine management of IDA in children with IBD.
Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis
Authors: Biskou Olga , Gardner‐Medwin Janet , Mackinder Mary , Bertz Martin , Clark Clare , Svolos Vaios , Russell Richard K. , Edwards Christine A. , McGrogan Paraic , Gerasimidis Konstantinos 
Published: August 2016

ABSTRACTThe present study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotectin (FC). FC was measured in 232 children; 55 children (n = 11 treatment naïve) with juvenile idiopathic arthritis (JIA), 63 with coeliac disease (CD); 17 with new diagnosis before and after treatment on gluten‐free diet and 114 controls. None of the treatment‐naive children with JIA had raised FC. Four JIA patients on treatment had a raised FC but in all cases a repeat test was normal. In newly diagnosed patients with CD, the median (interquartile range) FC was higher 36.4 (26–61) than that in controls 25.0 (23–41) mg/kg (P = 0.045) but this significantly decreased 25 (25–25) mg/kg (P = 0.012) after 6 months on gluten‐free diet. Random measurements of FC are not raised in children with JIA or CD. A significant elevation of FC in these groups is not explained by their diagnosis and therefore needs further investigation.
Retrospective PCR-based species identification of Leishmania in two patients with visceral leishmaniasis in Serbia
Authors: Dakić Zorica , Nielsen Henrik Vedel , Pavlović Milorad , Poluga Jasmina , Stevanović Goran , Lavadinović Lidija , Milošević Branko , Pelemiš Mijomir , Urošević Aleksandar , Jovanović Snežana , Stensvold Christen Rune 
Published: August 2016

Introduction:
Retrospective molecular identification of Leishmania parasites in two patients with visceral leishmaniasis (VL) previously treated in Serbia was carried out. DNA was isolated from unstained bone marrow smears (BMSs) kept for 11 and 8 years. Genus-specific real-time PCR was combined with conventional PCR and sequencing for detection and species identification.

Case presentation:
In 2003, a 40-year-old Serbian male was admitted to the Clinical Centre of Serbia (CCS) with fever, sweating, fatigue and splenomegaly, which developed over a period of 7 weeks. He had frequently travelled around Europe. VL was confirmed by microscopy of Giemsa-stained BMS. Treatment by pentavalent antimonials was successfully completed. Two years later, the patient developed post-kala-azar dermal leishmaniasis. Treatment resulted in symptom resolution. Later on, Leishmania infantum was identified as the causative agent of the VL by sequencing of the ITS (internal transcribed spacer) region; mixed Leishmania spp. infection could not be excluded. In 2006, a 33-year-old female from Vojvodina, Serbia, with pre-existing diabetes mellitus and chronic meningoencephalitis and a history of frequent visits to the Montenegrin seacoast, was admitted to the CCS with fever, pancytopenia and moderate hepatosplenomegaly. A stained BMS revealed abundant Leishmania amastigotes. Indirect haemagglutination analysis was positive with a titre of 1 : 2048, and a rapid dipstick rK39 test was also positive. Treatment by liposomal amphotericin B was successful; however, shortly after, the patient developed neural infection and pneumonia and died. The causative agent was identified as L. infantum.

Conclusion:
Molecular diagnosis of VL and species delineation using DNA from unstained BMSs stored for several years is possible.
Ethnicity as inclusion and exclusion
Authors: Baskerville Rachel F. , Jacobs Kerry , Joannides de Lautour Vassili , Sissons Jeff 
Published: August 2016

Purpose
Accounting research has struggled with how ethnicity is to be understood in relation to concepts such as nation and nationality and how ethnicity may impact on accounting and auditing practices, behaviours, education and professional values. These themes are explored and developed in the papers presented in this special issue. In particular, the purpose of this paper is to explore the contrasting theoretical and methodological approaches reflected by the papers in the issue.

Design/methodology/approach
This is a reflective and analytical paper which explores how notions of ethnicity are conceived and operationalised in accounting research. The authors identified two distinctive analytic ordering processes evident within this AAAJ Special issue: Mary Douglas’ scheme of Grid and Group and the Pierre Bourdieu’s conceptual tools of field, capital and habitus.

Findings
The “Grid and Group” Culture Theory with Bourdieu’s theoretical tools evident in the papers provide powerful tools to explore the relationship between ethnicity and accounting both conceptually and empirically, suggesting that ethnicity can be deployed to reveal and challenge institutionalised racism. This paper highlights the potential to integrate elements of the “Grid and Group” Culture Theory and Bourdieu’s theoretical tools. The issue of ethnicity and the relationship between ethnicity and accounting should be more fruitfully explored in future.

Research limitations/implications
The authors acknowledge the challenges and limitations of discussing the issue of ethnicity from any particular cultural perspective and recognise the implicit dominance of White Anglo centric perspectives within accounting research.

Originality/value
The papers presented in the special issue illustrate that the issue of ethnicity is complex and difficult to operationalise. This paper highlights the potential to move beyond the ad hoc application of theoretical and methodological concepts to operationalise coherent concepts which challenge and extend the authors’ understanding of accounting as a social and contextual practice. But to achieve this it is necessary to more clearly integrate theory, methodology, method and critique.
A critical analysis of ISO audits results
Authors: Arvanitoyannis Ioannis S. , Samourelis Konstantinos , Kotsanopoulos Konstantinos V. 
Published: August 2016

Purpose
The purpose of this paper is to summarize and analyse the results of several food quality and safety audits (ISO 9001, ISO 22000, ELOT 1416 and Codex Alimetarius) carried out in Greek food companies processing products of animal origin.

Design/methodology/approach
Specifically, both a quantitative and a qualitative review of the results were carried out.

Findings
It was revealed that the biggest ratio of non-conformities was recorded within the frame of ELOT 1416 standard (Greek scheme for the certification of HACCP Management Systems), or ELOT 1416 and ISO 9001 where a combination of standards was used. The highest ratio of observations was recorded against ELOT 1416 when used in combination with ISO 9001. The highest average of non-conformities per audit was recorded in meat (red meat and poultry) companies. With regards to the observations recorded, the highest average per audit was recorded in companies processing eggs. Considering the number of workers, the highest average of non-conformities per audit was observed in small companies.

Research limitations/implications
The limitations of the present study can be summarized into the fact that although a high number of audit reports were taken into account, an audit is an observation of the condition of a company on the day of the audit and the results can also be highly dependent on the skills of the auditors.

Originality/value
To the best of the authors’ knowledge this is the first paper that analyses a high number of audit reports from Greek food companies and its conclusions can be of significant value to both the auditors and the industry enabling a more focused approach in the conduction of audits and implementation of the standards.
Improving supply chain performance through industry standards use and community socialization
Authors: Xu Yun , Liu Jiafen , Wu Jing , Luo Chuan 
Published: August 2016

PurposeThe purpose of this paper is to examine how use of industry standards and community socialization contribute to the operational, strategic and environmental performances of supply chain partners.Design/methodology/approachSurvey data were collected from 216 firms in China that have implemented RosettaNet standards. Structural equation modeling was used to test the hypotheses forming the research model.FindingsThe empirical analysis suggests that use of industry standards and community socialization is central to achieving greater supply chain performances. The results show that the use of industry standards and community socialization enhance inter-organizational knowledge sharing and trust, which eventually improve performances of supply chain partners.Originality/valueThe study makes several contributions to the literature. First, it highlights the importance of standards consortia, which not only develop and promote industry standards, but also improve community socialization. Second, the research examines how use of industry standards could influence the operational, strategic and environmental performances of supply chains, and thus fills the research gap in related literature. Third, this paper explores how industry standards can be used as boundary objects to span organizational boundaries and enable greater supply chain partnerships.
Engaging customers during a website visit: a model of website customer engagement
Authors: Demangeot Catherine , Broderick Amanda J. 
Published: August 2016

Purpose
A customer’s visit to a retail website is a critical “moment of truth” during which contemporary retailers attempt to simultaneously, during a single web navigation, capture customers’ attention, build rapport, and prompt them to act. By showing how to capture customer commitment over the course of a single website visit, the concept of customer website engagement, defined as “the process of developing cognitive, affective and behavioural commitment to an active relationship with the website”, addresses strategic concerns. Drawing from literature on engagement, the purpose of this paper is to consider how retail websites can engage customers during the course of a website navigation. A conceptual model of website customer engagement underpinned by relationship marketing and communication knowledge, shows how perceptions of the website’s exploration and sense-making potential can activate consumer engagement, and is then empirically tested.

Design/methodology/approach
Using survey data, measures of the four dimensions of engagement (interaction engagement, activity engagement, behavioural engagement, and communication engagement) and of three drivers are developed and validated. The model is tested empirically (n=301) using structural equation modelling.

Findings
The results support the process conceptualisation of engagement, which identifies organismic as well as conative stages, and show the distinct roles played by perceptions of informational exploration, experiential exploration and sense-making in activating engagement.

Practical implications
The study provides online retailing practice with an organising framework enabling online retailing managers to consider how, depending on their product category and their size, they might (re)design their website to optimally produce customer engagement.

Originality/value
The study contributes to online marketing and retailing knowledge by showing the relevance of the concept of engagement as it pertains to customers’ single navigations on retail websites, and by empirically showing, through a parsimonious model, how engagement can be activated and unfold.
Reflections of environmental management implementation in furniture
Authors: Zutshi Ambika , Creed Andrew , Holmes Mary , Brain Jade 
Published: August 2016

Purpose
The purpose of this paper is to present an overview of environmental management initiatives in the furniture retail area. The specific aim is to present reflections of participants implementing environmental initiatives in an Australian furniture retailer, Living Edge, in alignment with a secondary snapshot of environmental initiatives from other furniture retailers.

Design/methodology/approach
Primary reflections from the retailer’s manager and external consultant, both involved in the implementation of environmental initiatives, are enriched with secondary review of environmental management system trends and examples from regions active in the designer furniture sector, including Europe, Southeast Asia and North America.

Findings
An integrated view has been distilled around environmental impact in the furniture supply chain and consumer pressure to minimise the impact. Stakeholders require furniture retailers to improve efficiency and profitability amid the countervailing market demand for environmental sustainability. Retailers may seek competitive advantage through effectively applied and communicated environmental management. The voluntary adoption of systems, international standards and innovative practices that conserve natural resources are amongst the key to success. A live case example of Australian experience is added to the knowledge base for the global retail furniture industry.

Research limitations/implications
One Australian retailer is exemplified to highlight the lived experiences of implementing environmental initiatives. The secondary global review presents a cross-section rather than an in-depth analysis of furniture sector retailers.

Originality/value
There are limited Australian perspectives of designer furniture and its intersection with environmental issues, thus, the paper addresses this gap in the literature and adds to informed practice in a global industry.
The value of information disclosure and lead investor in equity-based crowdfunding
Authors: Li Xuechun , Tang Yuehuan , Yang Ningrui , Ren Ruiyao , Zheng Haichao , Zhou Haibo 
Published: August 2016

PurposeHow to free the potential power of the capital market while simultaneously protecting the investors is critical in equity-based crowdfunding. To realize these goals, the purpose of this study was to investigate the value of information disclosure and leader-follower mechanism which have been widely adopted by crowdfunding platforms.Design/methodology/approachBased on the Elaboration Likelihood Model (ELM), a research framework was developed. Then, the authors conducted an in-depth exploratory empirical study of Dajiatou (www.dajiatou.com) which is a typical equity-based crowdfunding service provider in China. Independent-samplest-test and linear regression were used to uncover the value of project information disclosure and the lead investor in terms of fundraising performance improvement.FindingsFirst, the quality of entrepreneurial team information, especially the ratio of full-time staff, staff number and enterprise business age, significantly improve fundraising performance. Second, entrepreneurs’ behaviors, including project updates and project video, play important roles in crowdfunding. Third, whether or not the project has a lead investor, leader’s credibility information and his/her advocacy behaviors – percentage of their investment, identity certification, investment experience and comments for projects – are important factors affecting fundraising performance.Research limitations/implicationsThe authors are one of the firsts to apply ELM to investigate the effects of diverse information on fundraising performance in equity-based crowdfunding. The value of lead investor which has been ignored in prior research was studied through second-hand data.Practical implicationsFirst, an equity-based crowdfunding platform should request the entrepreneur to disclose project quality-related information with more details. Second, crowdfunding platforms should set a high qualifications level for lead investor, and limit the lead investor’s committed percentage in a specific project.Originality/valueThis paper extended the research in crowdfunding by uncovering the value of information disclosure and lead investor based on ELM theory.
Population‐specific genome‐wide mapping of expression quantitative trait loci in the colon of Han Chinese
Authors: Guo Chang Cun , Wei Ni , Liang Shu Hui , Wang Biao Luo , Sha Su Mei , Wu Kai Chun 
Published: August 2016

AbstractObjectiveTo establish the colonic expression quantitative trait locus map in Han Chinese population and provide a functional reference for interpreting genetic associations of diseases such as inflammatory bowel disease (IBD).MethodsColonic mucosal biopsies and peripheral blood samples were obtained from 48 Chinese Han individuals (24 ulcerative colitis patients and 24 healthy controls). Transcription profiling was performed using human whole genome expression array. Genotyping was done using a population‐specific genotype array. Imputation was performed using IMPUTE2. Association between genotypes and gene expression was analyzed using a Matrix Expression Quantitative Trait Loci (eQTL) R package to identify eQTL. We used ChIPpeakAnno R package for annotation of the eQTL. Linkage disequilibrium between the eQTL and IBD risk loci was also investigated.ResultsWe identified 6 377 single nucleotide polymorphism‐transcript interactions (cis‐eQTL) in the colon of the Chinese participants. Most of the eQTL located near the transcription starting sites and overlapped with histone modification marks on the genome. A significant proportion of the eQTL were found to be within transcription factor‐binding sites. Two IBD risk loci were found to be colon cis‐eQTL in Chinese individuals, and 51 cis‐eQTL were identified in another 18 IBD risk loci.ConclusionsThis study defined a population‐specific catalogue of colon eQTL in the Chinese population. Potential functional variants of IBD association signals were identified. We provided a useful reference dataset for fine mapping IBD risk loci and identifying causal variants in the Chinese Han population.
New vaccines: challenges of discovery
Authors: Mahmoud Adel 
Published: August 2016

SummaryVaccines have been a major component of preventing and controlling infectious diseases. The basis for discovery of what protects is reviewed as well as new attempts in utilizing Reverse Vaccinology, RNA‐RNA methods and proteome analysis are adding significantly to our knowledge. The challenge of how to define protective and defined components of microbes is still hampering efforts to discover new vaccines. Recent excitement about immunotherapy of cancer opens the way to develop vaccines against multiple malignancies.
Virtual vitreoretinal surgery: validation of a training programme
Authors: Vergmann Anna Stage , Vestergaard Anders Højslet , Grauslund Jakob 
Published: August 2016

AbstractPurposeTo test the validity of the eyesi surgical simulator as an assessment tool in a virtual reality vitreoretinal training programme.MethodsIn collaboration with an experienced vitreoretinal surgeon, a virtual vitreoretinal training programme was composed on the eyesi surgical simulator, software version 2.9.2 (VRmagic GmbH, Manheim, Germany). It was completed twice by three groups: 20 medical students, ten residents of ophthalmology and five trained vitreoretinal surgeons. The programme contained six training modules: navigation level 2 (Nav2), forceps training level 5 (ForT5), bimanual training level 3 (BimT3), laser coagulation level 3 (LasC3), posterior hyaloid level 3 (PostH3) and internal limiting membrane peeling level 3 (ILMP3). The scores in each module were assessed from two to five different factors (tissue treatment, efficiency, target achievement, instrument handling and microscope handling), and it was possible to achieve 100 points in each module.ResultsAt the final training session, the highest overall median score was found for the vitreoretinal surgeons (vitreoretinal surgeons: 434 points, residents: 394.5 points, medical students: 272.5 points, p < 0.01). This was also found in four of the six modules. These were Nav2 (p = 0.03), BimT3 (p < 0.01), PostH3 (p < 0.01) and ILMP3 (p < 0.01). On the other hand, the three groups did not differ regarding ForT5 (p = 0.16) or LasC3 (p = 0.75).ConclusionsWe developed a training programme with validity for the eyesi surgical simulator as an assessment tool for overall score and for four of six vitreoretinal modules. These findings could potentially make the programme a useful tool in the training of future vitreoretinal surgeons.