bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer as a Platform for Genetics Education in the Undergraduate Nursing Curriculum
Authors: Kiernan Jason , Vallerand April Hazard 
Published: April 2016

Background:
Nursing leaders and governing agencies have long requested more genetic content in the undergraduate nursing curriculum. Despite this, evidence in the literature detailing how to meet this objective is scarce.

Method:
Using a familiar health condition such as cancer, undergraduate nursing students are introduced to the multiple genetic abnormalities that underlie the cellular dysregulation leading to carcinogenesis.

Results:
Nursing students complete the course with a knowledge of cancer and its genetic underpinnings.

Conclusion:

This approach facilitated integration of genetic content in a disease-focused nursing course. [
J Nurs Educ
. 2016;55(4):236–239.]
Induction of Posterior Vitreous Detachment in Pediatric Vitrectomy by Preoperative Intravitreal Injection of Tissue Plasminogen Activator
Authors: Chuang Chih-Chun , Chen San-Ni 
Published: April 2016

Purpose:
To report the efficacy of intravitreal injection of tissue plasminogen activator (tPA) with or without autoserum in induction of posterior vitreous detachment (PVD) in pediatric vitrectomy.

Methods:
Retrospective, interventional case series of pediatric patients receiving intravitreal injection of tPA preoperatively to facilitate PVD in vitrectomy from January 2011 to December 2014 at the Changhua Christian Hospital, Taiwan. All patients received intravitreal injections of 25 µg of tPA 3 days before vitrectomy. For cases without preexisting vitreous hemorrhage, 0.1 mL of intravitreal autologous serum was co-administered. Main outcome measures included successful rate of posterior vitreous detachment in vitrectomy, visual outcome, and related ocular complications.

Results:
Four boys and 2 girls were included. Ages ranged from 39 weeks' postmenstrual age to 8 years. The indications for vitrectomy were traumatic macular hole (cases 1 and 2); premacular hemorrhage secondary to retinopathy of prematurity (case 3); abusive head trauma with premacular hemorrhage, subinternal limiting membrane hemorrhage, and macular hole (case 4); trauma with dense vitreous hemorrhage (case 5); and vitreous hemorrhage with unknown cause (case 6). Successful PVD was induced intraoperatively in all cases and the macular hole was closed successfully in 3 of 3 cases (cases 1, 2, and 4). No surgical complications were noted. Visual outcome improved in all 3 eyes with checkable preoperative visual acuity (cases 1, 2, and 6).

Conclusions:
Intravitreal injection of tPA 3 days before vitrectomy may be a helpful adjunct to induce pediatric PVD.

[
J Pediatr Ophthalmol Strabismus
. 2016;53(2):113–118.]
Quality of Vision After Wavefront-Guided or Wavefront-Optimized LASIK: A Prospective Randomized Contralateral Eye Study
Authors: Kung Jennifer S. , Manche Edward E. 
Published: April 2016

PURPOSE:
To compare the effect of wavefront-guided and wavefront-optimized LASIK using different laser platforms on subjective quality of vision.

METHODS:
The dominant eyes of 55 participants with myopia were randomized to receive either wavefront-guided LASIK treatment by the VISX Star S4 IR Custom-Vue excimer laser system (Abbott Medical Optics, Inc., Santa Clara, CA) or wavefront-optimized treatment by the WaveLight Allegretto Wave Eye-Q 400-Hz excimer laser system (Alcon Laboratories, Inc., Fort Worth, TX), whereas the fellow eye had the alternate laser treatment. Patients completed a questionnaire assessing quality of vision and visual symptoms (daytime and nighttime glare, daytime and nighttime clarity, halos, haze, fluctuating vision, and double vision) preoperatively and at postoperative months 1, 3, 6, and 12.

RESULTS:

At 3, 6, and 12 months postoperatively, there was no significant difference in any individual symptom between the wavefront-guided and wavefront-optimized groups, although at 12 months wavefront-guided eyes trended toward having more excellent vision (wavefront-guided vs wavefront-optimized; 2.26 vs 2.43;
P
= .039). In the subgroup of patients with preoperative root mean square (RMS) higher order aberrations (HOAs) less than 0.3
µ
m in both eyes, the wavefront-optimized group demonstrated a trend toward worsened nighttime clarity (
P
= .009), daytime clarity (
P
= .015), and fluctuating vision (
P
= .046), and less excellent vision (
P
= .009) at 12 months.

CONCLUSIONS:

Twelve months after surgery, most patients' self-reported visual symptoms were similar in eyes receiving wavefront-guided or wavefront-optimized LASIK. In general, 36% of patients preferred wavefront-guided LASIK, 19% preferred wavefront-optimized LASIK, and 45% had no preference at 12 months. The wavefront-guided preference was more pronounced in patients with lower baseline HOAs (RMS < 0.3
µ
m).

[
J Refract Surg
. 2016;32(4):230–236.]
Corneal Power Measurement With the Dual Scheimpflug-Placido Topographer After Myopic Excimer Laser Surgery
Authors: Pan Chao , Hua Yanjun , Huang Jinhai , Tan Weina , Lu Weicong , Wang Qinmei 
Published: April 2016

PURPOSE:
To evaluate the ability of the Sirius Scheimpflug-Placido Topographer (Costruzione Strumenti Oftalmici, Florence, Italy) in predicting corneal power in eyes with previous myopic corneal refractive surgery.

METHODS:
The following corneal refractive power measurements were obtained with Sirius in 38 eyes with prior myopic excimer laser surgery: simulated keratometry (SimK), true net power based on the Gaussian optical formula (TNP), and the mean pupil power (MPP) calculated by ray tracing within the diameter of the entrance pupil range from 2.5 to 6 mm. These values, along with the corresponding keratometric value, which was based on the equation that converted the MPP within 4.5-mm entrance pupil diameter to a keratometric reading in 75 myopic eyes, were compared using the clinical history method.

RESULTS:

SimK significantly overestimated corneal power by 0.67 ± 0.52 diopters (D), whereas TNP significantly underestimated corneal power by −1.05 ± 0.48 D. The only measurements that showed no statistically significant difference by the clinical history method were the 5 mm MPP, 5.5 mm MPP, and K
MPP4.5POST
, and the 95% limits of agreement (LOA) were −1.10 to 0.62, −0.91 to 0.89, and −0.67 to 1.05 D, respectively.

CONCLUSIONS:
The Sirius Scheimpflug-Placido Topographer is an alternative method of measuring corneal power in eyes with previous corneal refractive surgery for myopia when preoperative data are not available. The best options seem to be the 5 mm MPP, 5.5 mm MPP, and the keratometric reading calculated from the regression formula.

[
J Refract Surg.
2016;32(3):182–186.]
Evaluating Efficacy of Aflibercept in Refractory Exudative Age-Related Macular Degeneration With OCT Segmentation Volumetric Analysis
Authors: Choi Catherine S. , Zhang Li , Abràmoff Michael D. , Sonka Milan , Shifera Amde Selassie , Kay Christine N. 
Published: April 2016

BACKGROUND AND OBJECTIVE:
To use automated segmentation software to analyze spectral-domain optical coherence tomography (SD-OCT) scans and evaluate the effectiveness of aflibercept (Eylea; Regeneron, Tarrytown, NY) in the treatment of patients with exudative age-related macular degeneration (AMD) refractory to other treatments.

PATIENTS AND METHODS:
Retrospective chart review of 16 patients refractory to bevacizumab (Avastin; Genentech, South San Francisco, CA)/ranibizumab (Lucentis; Genentech, San Francisco, CA) treatment was conducted. Visual acuity, central foveal thickness (CFT), maximum fluid height, pigment epithelial detachment (PED) volume, sub-retinal fluid (SRF) volume, fluid-free time interval, and adverse effects were evaluated. Automated segmentation analysis was used to quantify improvement.

RESULTS:

With aflibercept treatment, there was a statistically significant improvement in visual acuity by 1 line (
P
= .020), in CFT by 74.02 µm (
P
= .001), and in maximum fluid height by 31.9 µm (
P
= .011). Total PED and SRF volume also decreased significantly by 1.50 µm
3
× 10
8
µm
3
(
P
= .013). Anatomic improvement was confirmed by automated segmentation analysis.

CONCLUSION:
This study demonstrates utility of automated segmentation software in quantifying anatomic improvement with aflibercept treatment in exudative AMD refractory to other anti-vascular endothelial growth factor treatments.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:245–251.]
Visualizing Macular Structures During Membrane Peeling Surgery With an Intraoperative Spectral-Domain Optical Coherence Tomography Device
Authors: Leisser Christoph , Hackl Christoph , Hirnschall Nino , Luft Nikolaus , Döller Birgit , Draschl Petra , Rigal Karl , Findl Oliver 
Published: April 2016

BACKGROUND AND OBJECTIVE:
The aim of this study was to examine the quality of intraoperative visualization of the posterior hyaloid, epiretinal membrane (ERM), inner limiting membrane (ILM), and hyporeflective subfoveal zone with a commercially available, microscope-integrated spectral-domain OCT setup (mi-SD-OCT) (Rescan 700; Carl Zeiss Meditec AG, Germany).

PATIENTS AND METHODS:
Twenty patients prospectively scheduled for pars plana vitrectomy with membrane peeling due to an idiopathic ERM were included. Standard 23-gauge, three-port pars plana vitrectomy with membrane peeling and staining of the ERM with a trypan blue-based chromovitrectomy dye was performed in all cases. Intraoperative SD-OCT was performed before and after peeling and visualization of the posterior hyaloid, ERM, ILM, and presence of subfoveal hyporeflective zones were examined. OCT follow-ups were performed 2 days and 3 months after surgery. The study was approved by the local ethics committee of the city of Vienna.

RESULTS:
Successful intraoperative visualization of ERM by mi-SD-OCT was possible in all cases. The posterior hyaloid and ILM could not be seen in the mi-SD-OCT scans, whereas an intraoperative subfoveal hyporeflective zone presented in 35% of cases. In 12.5% an independent subfoveal hyporeflective zone presented postoperatively. Visual acuity improved in 93.8% of patients after surgery.

CONCLUSION:
mi-SD-OCT appears to be a valuable tool for intraoperative visualization of the ERM and offers immediate visualization of retinal anatomy during peeling. Therefore, it adds to the understanding of intraoperative traumatic changes due to the peeling procedure.

[
Ophthalmic Surg Lasers Imaging Retina
. 2016;47:328–332.]
<b>The production of <i>Physalis</i> spp. seedlings grown under different-colored shade nets
Authors: Silva Daniel Fernandes da , Pio Rafael , Soares Joyce Dória Rodrigues , Nogueira Paulyene Vieira , Peche Pedro Maranha , Villa Fabíola 
Published: April 2016

The objective of this study was to evaluate the production of seedlings of Physalis L. species under different-colored shade nets. Four shade nets individually stained white, blue, red and black, all with 50% shading, were used in this study, and an additional treatment (control) was used in which seedlings were grown in full sun. The study examined four species of Physalis, namely, P. peruviana, P. pubescens, P. minima and P. ixocarpa. The experiment followed a randomized block design with three blocks and 25 seeds per plot. The species were sown in styrofoam trays. Germination was monitored daily to calculate the Emergency Velocity Index (EVI) and stabilize the overall percentage of emergence. Height, stem diameter, number of leaves, leaf area index and dry mass of seedlings were assessed at 50 days after sowing. The study found that these species react differently to changes in the light spectrum. Seedlings of P. peruviana should be grown under a white or red shade net; of P. pubescens under a white or black shade net; of P. minima under a white, red or black shade net; and of P. ixocarpa under a white shade net. For all species, 50% shade should be used.
The Softurator: When, Where and How We do It?
Authors: Shah Pratik Dipak , Mukherji Srijon 
Published: April 2016

ABSTRACT
Factors that affect management of surgical defects are surgical site, amount of remaining support tissue, presence of teeth and defect characteristics. When these factors are not favorable, successful prosthetic management of surgical defect becomes more challenging. Simultaneously, prosthesis should be comfortable to supporting and surrounding tissues as well as surgical defect. In the presented case, we have used soft polyvinyl siloxane material for fabrication of temporary surgical obturator to cover the surgical defect at the junction of hard and soft palates. Soft, flexible material is used for better adaptation to the changing morphology of surgical defect and also improves functions like speaking and swallowing.

How to cite this article
Shah PD, Mukherji S. The Softurator: When, Where and How We do It? Int J Head Neck Surg 2015; 6(2):93-95.
Effect of Continuous 6 Months Oral Antioxidant Combination with Universally recommended Dosage in Idiopathic Male Infertility
Authors: Chattopadhyay Ratna , Yasmin Shanawaz , Chakravarty BN 
Published: April 2016

ABSTRACTThe aim of the present study was to observe the adverse effects of high level of reactive oxygen species (ROS) in idiopathic male infertility and the role of a combined antioxidant therapy for six months to overcome the detrimental effects of ROS.A prospective study including 185 infertile male was conducted at Institute of Reproductive Medicine (IRM) from January 2014 to April 2015. All the major sperm parameters as well as ROS, antioxidant level and the effect of high ROS level were evaluated before and after the therapy.A significant improvement in sperm motility and concentration were observed after 6 months of therapy. Antioxidant level had increased and ROS level had decreased significantly after the antioxidant treatment. Improvement in morphology and leukocyte concentration were observed though not clinically significant.ConclusionThis combined antioxidant therapy may improve sperm quality after continuous 6 months of treatment. However, further study is needed regarding this experiment for validating the trend.How to cite this articleChattopadhyay R, Yasmin S, Chakravarty BN. Effect of Continuous 6 Months Oral Antioxidant Combination with Universally recommended Dosage in Idiopathic Male Infertility. Int J Infertil Fetal Med 2016;7(1):1-6.
Size of Endometrioma and Number does Influence the Ovarian Reserve: A Prospective Observational Study
Authors: Kumar Pratap , Sandya MR 
Published: April 2016

ABSTRACTBackgroundEndometriosis is one of the most commonly encountered benign problems in gynecology. Ultrasound and endocrine parameters have been widely accepted as markers of ovarian reserve. Anti-Mullerian hormone (AMH) in conjugation with antral follicle counts is now believed to be an excellent measure for detecting ovarian reserve. Surgical approach has a fundamental role in the management of endometriosis. The loss of normal follicles can be studied by histopathological assessment of the cyst wall. The postoperative decline in the ovarian reserve is believed to have a correlation with number of endometriomas and diameter of the cyst wall.ObjectiveThis prospective observational study was undertaken to evaluate the effect of laparoscopic cystectomy with respect to number and size of the cyst on ovarian reserve parameters.Materials and methodsFifty patients undergoing laparoscopic endometrioma cystectomy were analyzed. Cysts of <5cm and >5cm and the number of cysts were studied. Statistical analysis was done using Mauchly's test of sphericity. Anti-Mullerian hormone and antral follicle count were estimated prior to and 1 month after surgery. Pre- and postoperative values were compared and analyzed with respect to number and size of endometrioma.Observation and resultsThere was an overall drop of AMH from 3.8 ± 3.01 to 2.67 ± 1.92 ng/ml (p < 0.001). The mean AMH in bilateral and unilateral endometrioma was 2.9 ± 1.7 and 3.9 ± 3.17 ng/ml respectively. Anti-Mullerian hormone dropped from 4.53 ± 3.4 to 3.19 ± 2.18 with <5 cm cyst compared with 2.4 ± 1.2 to 1.7 ± 0.85 with >5 cm cyst (p < 0.01). Overall drop in AFC was 5.17 ± 1.44 and 3.61 ± 1.61 pre- and postoperative respectively (p < 0.01). Mean drop in AFC was 2.2 and 1.2 in cyst <5 and > 5 cm respectively. Histopathological analysis showed loss of follicles in 25% of the cyst walls. This was correlating with the drop in both AMH and AFC postoperatively.ConclusionSize and number of cyst does affect ovarian reserve to the effect that smaller and bilateral cyst leads to a greater decline in the same.How to cite this articleSandya MR, Kumar P. Size of Endometrioma and Number does Influence the Ovarian Reserve: A Prospective Observational Study. Int J Infertil Fetal Med 2016;7(1):14-18.
Role of Voice Therapy in Patients with Mutational Falsetto
Authors: Kumar Raj , Agrahari Alok Kumar 
Published: April 2016

ABSTRACT

Background
Mutational falsetto is the most common mutational voice disorder, found in all ages. Clinicians often miss this diagnosis due to unfamiliarity with the condition. The voice of a person with mutational falsetto is high pitched, weak, thin, breathy, hoarse and monopitched.

Objective
This study was carried out to evaluate the efficacy of voice therapy in persons with mutational falsetto.

Methods
Eleven male patients with ages between 18 and 26 years (mean age 22.18 years, SD 2.52) diagnosed with mutational falsetto underwent acoustical analysis using Praat Software, perceptual analysis using grade, roughness, breathiness, asthenia and strain (GRBAS) scale and psychosocial analysis using emotional component of voice handicap index (VHI). All the components were analyzed pre- and postvoice therapy.

Results
Improvement in acoustic analysis parameters was statistically significant with p-value less than 0.0001(pretherapy mean of fundamental frequency (F0) was 217.45 with SD 8.68, whereas post-therapy mean of F0 was 127.50 with SD 5.32). Significant improvement in perceptual analysis was seen post-therapy on GRBAS scale. Improvement in psychosocial aspect was also statistically significant with p-value less than 0.0001 (pre-therapy mean 26.18, SD 1.72 post-therapy mean 7, SD 1.15).

Conclusion
Voice therapy plays an important role in lowering F0 and alleviation mental agony of the patients with mutational falsetto.

How to cite this article
Varma A, Agrahari AK, Kumar R, Kumar V. Role of Voice Therapy in Patients with Mutational Falsetto. Int J Phonosurg Laryngol 2015;5(1):25-27
Transcontinental Links, Enlarged Maps, and Polycentric Structures in the History of World Christianity
Authors: Koschorke Klaus 
Published: April 2016

ABSTRACT
The new global situation of Christianity requires new historiographical approaches. This article presents and reflects upon the approach developed by the “Munich School of World Christianity,” which is guided by three leading principles: (1) the urgent need for new and enlarged maps of the global history of Christianity—which will enable us to describe the different denominational, regional, and cultural expressions of Christianity as part of a greater whole; (2) an awareness of “polycentric structures” throughout the history of world Christianity—not only in its most recent period but from its very beginnings; and (3) paying proper attention to transregional links and the resulting concept of a global history of Christianity as a history of multidirectional transcontinental interactions, which include early instances of South–South connections. A future history of world Christianity should pay close attention to these principles and rely on intensified interdisciplinary and cross-cultural cooperation.
A Response to Klaus Koschorke’s “Transcontinental Links, Enlarged Maps, and Polycentric Structures in the History of World Christianity”
Authors: Daniels David D. 
Published: April 2016

ABSTRACT
This response to Klaus Koschorke’s contribution to this issue profiles the new historiographical approach of the Munich School of World Christianity as a fresh perspective of study. Embracing a comparative studies approach to map the polycenters in Christianity’s global history, the Munich School in its comparative studies accents the similarities and dissimilarities between different ancient and new local Christian communities that might be connected by expanding and retracting networks. Focusing on multidirectional transcontinental interactions and exchanges, Koschorke and the Munich School ask: What are the South–South linkages created by “indigenous” or non-Western Christians? What are the nonwhite North-South linkages? With these new questions and the interrogations of new primary sources, they call us to widen our lenses, broaden the discussion, and deepen the analysis of the study of world Christianity.
Current Debates About the Approach of the “Munich School” and Further Perspectives on the Interdisciplinary Study of the History of World Christianity
Authors: Hermann Adrian , Burlacioiu Ciprian 
Published: April 2016

ABSTRACT
The research projects and publications of Klaus Koschorke and the “Munich School of World Christianity” have sparked intense debate over the last two decades. The first section of this article discusses some of these reactions and critiques, as well as Koschorke’s responses. It addresses questions about the idea of “polycentricity,” alternative ways of conceptualizing a variety of Christian centers, the relationship of Koschorke’s approach to the concept of transculturation, and the need for greater diversity and inclusiveness in scholarly perspectives. The second section outlines some important issues regarding challenges and further perspectives for writing a history of world Christianity in the future. It touches on the question of the geographic horizon(s) of this approach, debates about “transmission” and “appropriation,” and the role of the anthropology of Christianity in describing the fluid character of Christian movements. In addition, it addresses the problem of how to relate the history of world Christianity to a global history of religion, as well as the importance of considering issues of migration as central to our understanding of Christianity.
Publicizing Independence: The Filipino Ilustrado Isabelo de los Reyes and the “Iglesia Filipina Independiente” in a Colonial Public Sphere
Authors: Hermann Adrian 
Published: April 2016

ABSTRACT
On August 3, 1902, Isabelo de los Reyes y Florentino (1864–1938) proclaimed the establishment of an independent Philippine church, the Iglesia Filipina Independiente (IFI). Some of its activists (and later de los Reyes himself) soon began to publish two periodicals that served as the church’s official organs, containing important documents such as its constitution and pastoral letters. In this article I argue that these publications were of central importance to the IFI in its early years. They gave it a public voice, allowing it to bring its own concerns and interpretations of events to the Philippine public sphere. In doing so, the writers, especially de los Reyes, engaged in debates with other contemporary periodicals such as the Dominican friars’ Libertas and Pedro A. Paterno’s La Patria. At the same time, and in addition to these local concerns, these early IFI publications were essential to presenting the new Filipino national church as part of a global Christian community and to establishing the first contacts with other independent Catholic movements in Asia and beyond.