bluuebunny/crossref_metadata_2025_split huggingface dataset:
La gestión de El Fogón de los Arrieros y su implicancia en los procesos de patrimonialización del paisaje cultural de Resistencia, Chaco, Argentina
Authors: Sudar Klappenbach Luciana , Reyero Alejandra 
Published: March 2017

El artículo analiza, desde una perspectiva patrimonial, la relación entre la gestión de la institución cultural privada El Fogón de los Arrieros y la configuración del paisaje cultural de la ciudad de Resistencia, Chaco, Argentina. El punto de partida es la experiencia estética promovida por este espacio cultural en la década de 1960. A partir de allí indaga cómo ciertas prácticas culturales gestadas y promovidas por esta institución tuvieron su efecto en los procesos de valoración del patrimonio cultural y la conformación de imaginarios sociales. Considera como punto de inflexión los programas “la ciudad jardín” y “plan de embellecimiento”, y particularmente el caso de los murales “Génesis del Chaco” del artista Raúl Monsegur. El interés cultural que esta obra despertó en el pasado y la asignación de valores que pueden activarse en el presente (a través de su investigación y difusión), dan cuenta de las dinámicas de participación social al momento de reconocer el arte público local como patrimonio cultural. Para ello se examina la documentación de la época contenida en el archivo privado de la institución (notas periodísticas, correspondencia intercambiada entre artistas y gestores vinculados a El Fogón de los Arrieros, escritos publicados en los boletines oficiales de la agrupación, etc.) así como estudios previos sobre esta institución, y algunas de sus figuras más destacadas abordados desde el campo académico local.
Complete Genome Sequence of Streptococcus pyogenes
emm14
JS95, a Necrotizing Fasciitis Strain Isolated in Israel
Authors: Chee Jacqueline L. Y. , Ravins Miriam , Hanski Emanuel , Chen Swaine L. 
Published: March 2017

ABSTRACT

Here, we report the complete genome sequence of the
Streptococcus pyogenes
emm14
strain JS95, isolated from a patient with necrotizing fasciitis. The streptococcal invasion locus (
sil
), the first quorum-sensing system characterized in
S. pyogenes
, was identified in this strain.
Complete Genome Sequences of Three Rhizobium gallicum Symbionts Associated with Common Bean (Phaseolus vulgaris)
Authors: Bustos Patricia , Santamaría Rosa Isela , Pérez-Carrascal Olga María , Acosta José Luis , Lozano Luis , Juárez Soledad , Martínez-Flores Irma , Martínez-Romero Esperanza , Cevallos Miguel Ángel , Romero David , Dávila Guillermo , Vinuesa Pablo , Miranda Fabiola , Ormeño Ernesto , González Víctor 
Published: March 2017

ABSTRACT

The whole-genome sequences of three strains of
Rhizobium gallicum
reported here support the concept that the distinct nodulation host ranges displayed by the symbiovars gallicum and phaseoli can be largely explained by different symbiotic plasmids.
Genome Sequence of
Arcobacter
sp. Strain LA11, Isolated from the Abalone
Haliotis discus
Authors: Mizutani Yukino , Tanaka Reiji 
Published: March 2017

ABSTRACT

Arcobacter
sp. strain LA11 was isolated from the gut of the abalone
Haliotis discus
. Here, we present the annotation and analysis of the draft genome of this strain, which is involved in nitrogen metabolism.
Genome Sequences of Mycobacteriophages Jane and Sneeze, New Members of Cluster G
Authors: Mageeney Catherine M. , Bhalla Cimrin , Bowman Charles A. , Devireddy Bhavishya , Dzurick Adrienne P. , Graham Lee H. , Grossi Marina , Kenna Margaret A. , Kowal Mikala A. , Nielsen Drew D. , Pallay Rachel A. , Ruffing Kaitlyn M. , Russell Daniel A. , Sarli Samantha L. , Shaw Adama , Skibbens Joseph W. , Teyim Joseph N. , Ware Vassie C. 
Published: March 2017

ABSTRACT

Jane and Sneeze are newly isolated phages of
Mycobacterium smegmatis
mc
2
155 from Hillsborough, NJ, and Palo Verde, Costa Rica, respectively. Both are cluster G, subcluster G1 mycobacteriophages. Notable nucleotide differences exist between genomes in the right half, including the presence of mycobacteriophage mobile element 1 (MPME1) in Jane.
Complete Genome and Methylome Analysis of Psychrotrophic Bacterial Isolates from Lake Untersee in Antarctica
Authors: Fomenkov Alexey , Akimov Vladimir N. , Vasilyeva Lina V. , Andersen Dale T. , Vincze Tamas , Roberts Richard J. 
Published: March 2017

ABSTRACT
This paper describes the complete genome sequences and methylome analysis of six psychrotrophic strains isolated from perennially ice-covered Lake Untersee in Antarctica.
Role of Surgery in the Diagnosis and Management of Tuberculosis
Authors: Sihoe Alan D. L. 
Published: March 2017

ABSTRACT
Modern thoracic surgery can now offer management of tuberculosis and its complications in selected patients with greater efficacy and less morbidity than ever before. Significantly, newer minimally invasive thoracic surgical approaches potentially lower thresholds for surgical candidacy, allowing more tuberculosis patients to receive operative treatment. This review aims to provide an overview of the role that modern thoracic surgery can play in diagnosing and managing patients with tuberculosis and its sequelae.
Financial modelling of femtosecond laser-assisted cataract surgery within the National Health Service using a ‘hub and spoke’ model for the delivery of high-volume cataract surgery
Authors: Roberts H W , Ni M Z , O'Brart D P S 
Published: March 2017

AimsTo develop financial models which offset additional costs associated with femtosecond laser (FL)-assisted cataract surgery (FLACS) against improvements in productivity and to determine important factors relating to its implementation into the National Health Service (NHS).MethodsFL platforms are expensive, in initial purchase and running costs. The additional costs associated with FL technology might be offset by an increase in surgical efficiency. Using a ‘hub and spoke’ model to provide high-volume cataract surgery, we designed a financial model, comparing FLACS against conventional phacoemulsification surgery (CPS). The model was populated with averaged financial data from 4 NHS foundation trusts and 4 commercial organisations manufacturing FL platforms. We tested our model with sensitivity and threshold analyses to allow for variations or uncertainties.ResultsThe averaged weekly workload for cataract surgery using our hub and spoke model required either 8 or 5.4 theatre sessions with CPS or FLACS, respectively. Despite reduced theatre utilisation, CPS (average £433/case) was still found to be 8.7% cheaper than FLACS (average £502/case). The greatest associated cost of FLACS was the patient interface (PI) (average £135/case). Sensitivity analyses demonstrated that FLACS could be less expensive than CPS, but only if increased efficiency, in terms of cataract procedures per theatre list, increased by over 100%, or if the cost of the PI was reduced by almost 70%.ConclusionsThe financial viability of FLACS within the NHS is currently precluded by the cost of the PI and the lack of knowledge regarding any gains in operational efficiency.
Introduction of a Microsoft Excel-based unified electronic weekend handover document in Acute and General Medicine in a DGH: aims, outcomes and challenges
Authors: Kostelec Pablo , Emanuele Garbelli Pietro , Emanuele Garbelli Pietro 
Published: March 2017

On-call weekends in medicine can be a busy and stressful time for junior doctors, as they are responsible for a larger pool of patients, most of whom they would have never met.Clinical handover to the weekend team is extremely important and any communication errors may have a profound impact on patient care, potentially even resulting in avoidable harm or death.Several senior clinical bodies have issued guidelines on best practice in written and verbal handover. These include: standardisation, use of pro forma documents prompting doctors to document vital information (such as ceiling of care/resuscitation status) and prioritisation according to clinical urgency.These guidelines were not consistently followed in our hospital site at the onset of 2014 and junior doctors were becoming increasingly dissatisfied with the handover processes.An initial audit of handover documents used across the medical division on two separate weekends in January 2014, revealed high variability in compliance with documentation of key information. For example, ceiling of care was documented for only 14-42% of patients and resuscitation status in 26-72% of patients respectively. Additionally, each ward used their own self-designed pro forma and patients were not prioritised by clinical urgency.Within six months from the introduction of a standardised, hospital-wide weekend handover pro forma across the medical division and following initial improvements to its layout, ceiling of therapy and resuscitation status were documented in approximately 80% of patients (with some minor variability). Moreover, 100% of patients in acute medicine and 75% of those in general medicine were prioritised by clinical urgency and all wards used the same handover pro forma.
Predicting intraprocedural rupture and thrombus formation during coiling of ruptured anterior communicating artery aneurysms
Authors: Fan Lianghao , Lin Boli , Xu Ting , Xia Nengzhi , Shao Xiaotong , Tan Xianxi , Zhong Ming , Yang Yunjun , Zhao Bing 
Published: March 2017

BackgroundIntraprocedural rupture and thrombus formation are serious complications during coiling of ruptured intracranial aneurysms, and they more often occur in patients with anterior communicating artery (ACoA) aneurysms.ObjectiveTo identify independent predictors of intraprocedural rupture and thrombus formation during coiling of ruptured ACoA aneurysms.MethodsBetween January 2008 and February 2015, 254 consecutive patients with 255 ACoA aneurysms were treated with coiling. We retrospectively reviewed intraoperative angiograms and medical records to identify intraprocedural rupture and thrombus formation, and re-measured aneurysm morphologies using CT angiography images. Multivariate logistic regression models were used to determine independent predictors of intraprocedural rupture and thrombus formation.ResultsOf the 231 patients included, intraprocedural rupture occurred in 10 (4.3%) patients, and thrombus formation occurred in 15 (6.5%) patients. Patients with smaller aneurysms more often experienced intraprocedural rupture than those with larger aneurysms (3.5±1.3 mm vs 5.7±2.3 mm). Multivariate analysis showed that smaller ruptured aneurysms (p=0.003) were independently associated with intraprocedural rupture. The threshold of aneurysm size separating rupture and non-rupture groups was 3.5 mm. Multivariate analysis showed that a history of hypertension (p=0.033), aneurysm neck size (p=0.004), and parent vessel angle (p=0.023) were independent predictors of thrombus formation. The threshold of parent vessel angle separating thrombus and non-thrombus groups was 60.0°.ConclusionsRuptured aneurysms <3.5 mm were associated with an increased risk of intraprocedural rupture, and parent vessel angle <60.0°, wider-neck aneurysms, and a history of hypertension were associated with increased risk of thrombus formation during coiling of ruptured ACoA aneurysms.
Tobacco cessation and household spending on non-tobacco goods: results from the US Consumer Expenditure Surveys
Authors: Rogers Erin S , Dave Dhaval M , Pozen Alexis , Fahs Marianne , Gallo William T 
Published: March 2017

ObjectivesTo estimate the impact of tobacco cessation on household spending on non-tobacco goods in the USA.MethodsUsing 2006–2015 Consumer Expenditure Survey data, 9130 tobacco-consuming households were followed for four quarters. Households were categorised during the fourth quarter as having: (1) recent tobacco cessation, (2) long-term cessation, (3) relapsed cessation or (4) no cessation. Generalised linear models were used to compare fourth quarter expenditures on alcohol, food at home, food away from home, housing, healthcare, transportation, entertainment and other goods between the no-cessation households and those with recent, long-term or relapsed cessation. The full sample was analysed, and then analysed by income quartile.ResultsIn the full sample, households with long-term and recent cessation had lower spending on alcohol, food, entertainment and transportation (p<0.001). Recent cessation was further associated with reduced spending on food at home (p<0.001), whereas relapsed cessation was associated with higher spending on healthcare and food away from home (p<0.001). In the highest income quartile, long-term and recent cessations were associated with reduced alcohol spending only (p<0.001), whereas in the lowest income quartile, long-term and recent cessations were associated with lower spending on alcohol, food at home, transportation and entertainment (p<0.001).ConclusionsHouseholds that quit tobacco spend less in areas that enable or complement their tobacco cessation, most of which may be motivated by financial strain. The most robust association between tobacco cessation and spending was the significantly lower spending on alcohol.
Inhibition of Smooth Muscle β-Catenin Hinders Neointima Formation After Vascular Injury
Authors: Riascos-Bernal Dario F. , Chinnasamy Prameladevi , Gross Jordana N. , Almonte Vanessa , Egaña-Gorroño Lander , Parikh Dippal , Jayakumar Smitha , Guo Liang , Sibinga Nicholas E.S. 
Published: March 2017

Objective—
Smooth muscle cells (SMCs) contribute to neointima formation after vascular injury. Although β-catenin expression is induced after injury, whether its function is essential in SMCs for neointimal growth is unknown. Moreover, although inhibitors of β-catenin have been developed, their effects on SMC growth have not been tested. We assessed the requirement for SMC β-catenin in short-term vascular homeostasis and in response to arterial injury and investigated the effects of β-catenin inhibitors on vascular SMC growth.

Approach and Results—

We used an inducible, conditional genetic deletion of β-catenin in SMCs of adult mice. Uninjured arteries from adult mice lacking SMC β-catenin were indistinguishable from controls in terms of structure and SMC marker gene expression. After carotid artery ligation, however, vessels from mice lacking SMC β-catenin developed smaller neointimas, with lower neointimal cell proliferation and increased apoptosis. SMCs lacking β-catenin showed decreased mRNA expression of
Mmp2
,
Mmp9
,
Sphk1
, and
S1pr1
(genes that promote neointima formation), higher levels of
Jag1
and
Gja1
(genes that inhibit neointima formation), decreased Mmp2 protein expression and secretion, and reduced cell invasion in vitro. Moreover, β-catenin inhibitors PKF118-310 and ICG-001 limited growth of mouse and human vascular SMCs in a dose-dependent manner.

Conclusions—
SMC β-catenin is dispensable for maintenance of the structure and state of differentiation of uninjured adult arteries, but is required for neointima formation after vascular injury. Pharmacological β-catenin inhibitors hinder growth of human vascular SMCs. Thus, inhibiting β-catenin has potential as a therapy to limit SMC accumulation and vascular obstruction.
STING–IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity
Authors: Mao Yun , Luo Wei , Zhang Lin , Wu Weiwei , Yuan Liangshuai , Xu Hao , Song Juhee , Fujiwara Keigi , Abe Jun-ichi , LeMaire Scott A. , Wang Xing Li , Shen Ying H. 
Published: March 2017

Objective—
Metabolic stress in obesity induces endothelial inflammation and activation, which initiates adipose tissue inflammation, insulin resistance, and cardiovascular diseases. However, the mechanisms underlying endothelial inflammation induction are not completely understood. Stimulator of interferon genes (STING) is an important molecule in immunity and inflammation. In the present study, we sought to determine the role of STING in palmitic acid–induced endothelial activation/inflammation.

Approach and Results—

In cultured endothelial cells, palmitic acid treatment activated STING, as indicated by its perinuclear translocation and binding to interferon regulatory factor 3 (IRF3), leading to IRF3 phosphorylation and nuclear translocation. The activated IRF3 bound to the promoter of ICAM-1 (intercellular adhesion molecule 1) and induced ICAM-1 expression and monocyte–endothelial cell adhesion. When analyzing the upstream signaling, we found that palmitic acid activated STING by inducing mitochondrial damage. Palmitic acid treatment caused mitochondrial damage and leakage of mitochondrial DNA into the cytosol. Through the cytosolic DNA sensor cGAS (cyclic GMP-AMP synthase), the mitochondrial damage and leaked cytosolic mitochondrial DNA activated the STING–IRF3 pathway and increased ICAM-1 expression. In mice with diet-induced obesity, the STING–IRF3 pathway was activated in adipose tissue. However, STING deficiency (
Sting

gt/gt

) partially prevented diet-induced adipose tissue inflammation, obesity, insulin resistance, and glucose intolerance.

Conclusions—
The mitochondrial damage-cGAS–STING–IRF3 pathway is critically involved in metabolic stress–induced endothelial inflammation. STING may be a potential therapeutic target for preventing cardiovascular diseases and insulin resistance in obese individuals.
Pregnancy and the Risk of Spontaneous Coronary Artery Dissection
Authors: Havakuk Ofer , Goland Sorel , Mehra Anil , Elkayam Uri 
Published: March 2017

Background—
Because of the rarity of this condition, information on pregnancy-associated spontaneous coronary artery dissection is limited. We reviewed a large number of contemporary pregnancy-associated spontaneous coronary artery dissection cases in an attempt to define the clinical characteristics and provide management recommendations.

Methods and Results—
A literature search for cases of pregnancy-associated spontaneous coronary artery dissection reported between 2000 and 2015 included 120 cases; 75% presented with ST-segment–elevation myocardial infarction, and 80% had anterior myocardial infarction. Left anterior descending coronary artery was involved in 72% of cases, left main segment in 36%, and 40% had multivessel spontaneous coronary artery dissection. Ejection fraction was reduced to <40% in 44% of cases. Percutaneous coronary intervention was successful in only 50% of cases. Coronary artery bypass surgery was performed in 44 cases because of complex anatomy, hemodynamic instability, or failed percutaneous coronary intervention. Maternal complications included cardiogenic shock (24%), mechanical support (28%), urgent percutaneous coronary intervention (28%), urgent coronary artery bypass surgery (27.5%), maternal mortality (4%), and fetal mortality (2.5%). During follow-up for 305±111 days, there was a high incidence of symptoms because of persistent or new spontaneous coronary artery dissections, and 5 women needed heart transplantation or ventricular assist device implantation.

Conclusions—
Pregnancy-associated spontaneous coronary artery dissection is commonly associated with left anterior descending, left main, and multivessel involvement, which leads to a high incidence of reduced ejection fraction, and life-threatening maternal and fetal complications. Percutaneous coronary intervention is associated with low success rate and high likelihood of complications, and coronary artery bypass surgery is often required. Recurrent ischemic events because of persistent or new spontaneous coronary artery dissection are common during long-term follow-up.
Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility
Authors: Wang Dan , Wang Feng , Shi Kai-Hu , Tao Hui , Li Yang , Zhao Rui , Lu Han , Duan Wenyuan , Qiao Bin , Zhao Shi-Min , Wang Hongyan , Zhao Jian-Yuan 
Published: March 2017

Background:
Folate deficiency is an independent risk factor for congenital heart disease (CHD); however, the maternal plasma folate level is paradoxically not a good diagnostic marker. Genome-wide surveys have identified variants of nonfolate metabolic genes associated with the plasma folate level, suggesting that these genetic polymorphisms are potential risk factors for CHD.

Methods:
To examine the effects of folate concentration-related variations on CHD risk in the Han Chinese population, we performed 3 independent case-control studies including a total of 1489 patients with CHD and 1745 control subjects. The expression of the Fidgetin (FIGN) was detected in human cardiovascular and decidua tissue specimens with quantitative real-time polymerase chain reaction and Western blotting. The molecular mechanisms were investigated by luciferase reporter assays, surface plasmon resonance, and chromatin immunoprecipitation. FIGN-interacting proteins were confirmed by tandem affinity purification and coimmunoprecipitation. Proteasome activity and metabolite concentrations in the folate pathway were quantified with a commercial proteasome activity assay and immunoassays, respectively.

Results:

The +94762G>C (rs2119289) variant in intron 4 of the
FIGN
gene was associated with significant reduction in CHD susceptibility (
P
=5.1×10
−14
for the allele,
P
=8.5×10
–−13
for the genotype). Analysis of combined samples indicated that CHD risks in individuals carrying heterozygous (GC) or homozygous (CC) genotypes were reduced by 44% (odds ratio [OR]=0.56; 95% confidence interval [CI]=0.47–0.67) and 66% (OR=0.34; 95% CI=0.23–0.50), respectively, compared with those with the major GG genotype. Minor C allele carriers who had decreased plasma folate levels exhibited significantly increased
FIGN
expression because the transcription suppressor CREB1 did not bind the alternative promoter of
FIGN
isoform X3. Mechanistically, increased FIGN expression led to the accumulation of both reduced folate carrier 1 and dihydrofolate reductase via inhibition of their proteasomal degradation, which promoted folate absorption and metabolism.

Conclusions:

We report a previously undocumented finding that decreased circulating folate levels induced by increased folate transmembrane transport and utilization, as determined by the
FIGN
intronic variant, serves as a protective mechanism against CHD. Our results may explain why circulating folate levels do not have a good diagnostic value.
A new nomenclatural combination in Schoenoplectiella (Cyperaceae)
Authors: DANYLYK IVAN M. , OLSHANSKYI IGOR G. , ZHYGALOVA SVITLANA L. 
Published: March 2017

The genus Schoenoplectiella Lye (2003: 20) (Cyperaceae) was recently established to accommodate species earlier usually placed in Schoenoplectus (Reichenbach, 1846: 40) Palla (1888: 49) or Scirpus Linnaeus (1753: 47). As currently circumscribed, this genus contains about 50 species (Lye 2003, Kim et al. 2012, Govaerts et al. 2016). Recent molecular phylogenetic studies (Jung & Choi 2011a, 2011b, Shiels et al. 2014) demonstrated that Schoenoplectiella is a sister group to Schoenoplectus sensu stricto.