bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating run‐time changes into system and software process enactment
Authors: Tran Hanh Nhi , Hajmoosaei Mojtaba , Percebois Christian , Front Agnes , Roncancio Claudia 
Published: April 2016

AbstractIn System and Software Engineering development, unforeseen changes occurring during process enactment are almost inevitable but often poorly managed due to a lack of efficient mechanisms for spontaneously handling these run‐time changes. We proposed a change‐aware process management system that allows process actors reporting emergent changes, analyzing possible impacts, and notifying people affected by the changes. To this end, we integrated a Change Management Component with a Process Management System. The Process Management System monitors process enactment and uses the run‐time process information to construct a Process dependency graph (PDG) representing the dependencies among the elements of running processes. The Change Management Component captures change requests sent asynchronously, then reasons the PDG to determine impacted elements. Our PDG reflects the information of process instances and therefore can uncover the intra‐process or inter‐processes dependencies that are invisible on process models. We implemented a prototype named CAPE based on the platform jBPM and the graph database Neo4j. Copyright © 2016 John Wiley & Sons, Ltd.
A New Priority
Authors: Dougherty Stahl Katherine A. 
Published: April 2016

AbstractTeachers in primary classrooms who are emphasizing high‐level comprehension of complex texts are seeing young children hit comprehension thresholds that were previously only visible among older readers. However, most primary level reading interventions focus on word recognition skills or reading increasingly difficult leveled texts. This article describes the assessment procedures needed to identify the children who need additional support and to diagnose their specific comprehension needs. It also describes research‐validated protocols for improving narrative comprehension and informational text comprehension.
Response to Intervention
Authors: Dougherty Stahl Katherine A. 
Published: April 2016

AbstractResponse to Intervention (RTI) is a multiple tiered system of instructional interventions that may also serve to identify children with Specific Learning Disabilities (particularly in reading and spelling). This article summarizes the findings of Evaluation of Response to Intervention Practices for Elementary School Reading (Balu, Zhu, Doolittle, Schiller, Jenkins, & Gersten, 2015). It concludes with a list of implications and suggestions for how schools might update and refine their RTI framework based on the federal study's findings.
Adaptive robust polynomial regression for power curve modeling with application to wind power forecasting
Authors: Xu Man , Pinson Pierre , Lu Zongxiang , Qiao Ying , Min Yong 
Published: April 2016

AbstractWind farm power curve modeling, which characterizes the relationship between meteorological variables and power production, is a crucial procedure for wind power forecasting. In many cases, power curve modeling is more impacted by the limited quality of input data rather than the stochastic nature of the energy conversion process. Such nature may be due the varying wind conditions, aging and state of the turbines, etc. And, an equivalent steady‐state power curve, estimated under normal operating conditions with the intention to filter abnormal data, is not sufficient to solve the problem because of the lack of time adaptivity. In this paper, a refined local polynomial regression algorithm is proposed to yield an adaptive robust model of the time‐varying scattered power curve for forecasting applications. The time adaptivity of the algorithm is considered with a new data‐driven bandwidth selection method, which is a combination of pilot estimation based on blockwise least‐squares parabolic fitting and the probability integral transform. The regression model is then extended to a more robust one, in which a new dynamic forgetting factor is defined to make the estimator forget the out‐of‐date data swiftly and also achieve a better trade‐off between robustness against noisy data and time adaptivity. A case study based on a real‐world dataset validates the properties of the proposed regression method. Results show that the new method could flexibly respond to abnormal data at different lead times and has better performance than common benchmarks for short‐term forecasting. Copyright © 2016 John Wiley & Sons, Ltd.
Air‐Stable, Well‐Soluble AI2[Nb6Cl18] Cluster Compounds (AI = Organic Cation): A New Route for Preparation, Single‐Crystal Structures, Properties, and ESI‐Mass Spectra
Authors: König Jonas , Dartsch Ina , Topp A. , Guillamón Eva , Llusar Rosa , Köckerling Martin 
Published: April 2016

Abstract Five niobium cluster compounds of the AI2[Nb6Cl18] type (AI = organic cation: [nPr4N]+, [nBu4N]+, [BMIm]+, [Ph4P]+, and [PPN]+) are obtained through treatment of [Nb6Cl14(H2O)4]·4H2O with excess of thionyl chloride in the presence of an organic chloride, AICl. Single‐crystal structure studies show that the compounds consist of discrete cations and cluster [Nb6Cl18]2– anions. The cluster unit of the hydrated cluster starting material is oxidized by two electrons. Powder diffraction studies and NMR spectroscopic measurements show all compounds to crystallize without co‐crystallized solvent molecules. They are air and water stable. The solubility in organic solvents changes to a great extent on changing the type of cation. The ESI‐MS spectra of [nPr4N]2[Nb6Cl18] and [Ph4P]2[Nb6Cl18] show the pseudomolecular peak of the anionic cluster as well as additional signals, which involve simultaneously chloride mass loss and reduction processes.
An Unfinished ‘Diplomacy of Encounter’ – Asia and the West 1500–2015
Authors: CHONG ALAN 
Published: April 2016

AbstractAsian diplomatic practices consistently frustrate western policymakers. This, I argue, is due in large part to cultural factors and the differences in interpreting political modernization. I will identify the features that contribute to a ‘diplomacy of encounter’ by, firstly, performing a historical reading of early indigenous annals that treat diplomacy in Asia, as well as of Jesuit and Portuguese encounters with Asia in the 1500s and 1600s; secondly, by reading a sample of nationalist tracts from Asia between the late 1800s and 1960s; and, thirdly, by reading the practices of ASEAN and wider Asia-Pacific regionalism between the 1990s and 2000s. It is only through discourse analysis of the Foucaultian variety that one can tease out the cultural and modernization-related road bumps in so-called ‘modern Asian diplomacy’. This study hopes to contribute to enhancing appreciation of the ongoing procedural and substantive tensions between Asian states and their western, and mostly developed, dialogue partners.
Sn-doped Bi1.1Sb0.9Te2S bulk crystal topological insulator with excellent properties
Authors: Kushwaha S. K. , Pletikosić I. , Liang T. , Gyenis A. , Lapidus S. H. , Tian Yao , Zhao He , Burch K. S. , Lin Jingjing , Wang Wudi , Ji Huiwen , Fedorov A. V. , Yazdani Ali , Ong N. P. , Valla T. , Cava R. J. 
Published: April 2016

AbstractA long-standing issue in topological insulator research has been to find a bulk single crystal material that provides a high-quality platform for characterizing topological surface states without interference from bulk electronic states. This material would ideally be a bulk insulator, have a surface state Dirac point energy well isolated from the bulk valence and conduction bands, display quantum oscillations from the surface state electrons and be growable as large, high-quality bulk single crystals. Here we show that this material obstacle is overcome by bulk crystals of lightly Sn-doped Bi1.1Sb0.9Te2S grown by the vertical Bridgman method. We characterize Sn-BSTS via angle-resolved photoemission spectroscopy, scanning tunnelling microscopy, transport studies, X-ray diffraction and Raman scattering. We present this material as a high-quality topological insulator that can be reliably grown as bulk single crystals and thus studied by many researchers interested in topological surface states.
Optical painting and fluorescence activated sorting of single adherent cells labelled with photoswitchable Pdots
Authors: Kuo Chun-Ting , Thompson Alison M. , Gallina Maria Elena , Ye Fangmao , Johnson Eleanor S. , Sun Wei , Zhao Mengxia , Yu Jiangbo , Wu I-Che , Fujimoto Bryant , DuFort Christopher C. , Carlson Markus A. , Hingorani Sunil R. , Paguirigan Amy L. , Radich Jerald P. , Chiu Daniel T. 
Published: April 2016

AbstractThe efficient selection and isolation of individual cells of interest from a mixed population is desired in many biomedical and clinical applications. Here we show the concept of using photoswitchable semiconducting polymer dots (Pdots) as an optical ‘painting’ tool, which enables the selection of certain adherent cells based on their fluorescence, and their spatial and morphological features, under a microscope. We first develop a Pdot that can switch between the bright (ON) and dark (OFF) states reversibly with a 150-fold contrast ratio on irradiation with ultraviolet or red light. With a focused 633-nm laser beam that acts as a ‘paintbrush’ and the photoswitchable Pdots as the ‘paint’, we select and ‘paint’ individual Pdot-labelled adherent cells by turning on their fluorescence, then proceed to sort and recover the optically marked cells (with 90% recovery and near 100% purity), followed by genetic analysis.
Ear-body lift and a novel thrust generating mechanism revealed by the complex wake of brown long-eared bats (Plecotus auritus)
Authors: Johansson L. Christoffer , Håkansson Jonas , Jakobsen Lasse , Hedenström Anders 
Published: April 2016

AbstractLarge ears enhance perception of echolocation and prey generated sounds in bats. However, external ears likely impair aerodynamic performance of bats compared to birds. But large ears may generate lift on their own, mitigating the negative effects. We studied flying brown long-eared bats, using high resolution, time resolved particle image velocimetry, to determine the aerodynamics of flying with large ears. We show that the ears and body generate lift at medium to cruising speeds (3–5 m/s), but at the cost of an interaction with the wing root vortices, likely reducing inner wing performance. We also propose that the bats use a novel wing pitch mechanism at the end of the upstroke generating thrust at low speeds, which should provide effective pitch and yaw control. In addition, the wing tip vortices show a distinct spiraling pattern. The tip vortex of the previous wingbeat remains into the next wingbeat and rotates together with a newly formed tip vortex. Several smaller vortices, related to changes in circulation around the wing also spiral the tip vortex. Our results thus show a new level of complexity in bat wakes and suggest large eared bats are less aerodynamically limited than previous wake studies have suggested.
Development of camelid single chain antibodies against Shiga toxin type 2 (Stx2) with therapeutic potential against Hemolytic Uremic Syndrome (HUS)
Authors: Mejías Maria P. , Hiriart Yanina , Lauché Constanza , Fernández-Brando Romina J. , Pardo Romina , Bruballa Andrea , Ramos María V. , Goldbaum Fernando A. , Palermo Marina S. , Zylberman Vanesa 
Published: April 2016

AbstractShiga toxin (Stx)-producing Escherichia coli (STEC) infections are implicated in the development of the life-threatening Hemolytic Uremic Syndrome (HUS). Despite the magnitude of the social and economic problems caused by STEC infections, no licensed vaccine or effective therapy is presently available for human use. Single chain antibodies (VHH) produced by camelids exhibit several advantages in comparison with conventional antibodies, making them promising tools for diagnosis and therapy. In the present work, the properties of a recently developed immunogen, which induces high affinity and protective antibodies against Stx type 2 (Stx2), were exploited to develop VHHs with therapeutic potential against HUS. We identified a family of VHHs against the B subunit of Stx2 (Stx2B) that neutralize Stx2 in vitro at subnanomolar concentrations. One VHH was selected and was engineered into a trivalent molecule (two copies of anti-Stx2B VHH and one anti-seroalbumin VHH). The resulting molecule presented extended in vivo half-life and high therapeutic activity, as demonstrated in three different mouse models of Stx2-toxicity: a single i.v. lethal dose of Stx2, several i.v. incremental doses of Stx2 and intragastrical STEC infection. This simple antitoxin agent should offer new therapeutic options for treating STEC infections to prevent or ameliorate HUS outcome.
Secretory pathway retention of mutant prion protein induces p38-MAPK activation and lethal disease in mice
Authors: Puig Berta , Altmeppen Hermann C. , Ulbrich Sarah , Linsenmeier Luise , Krasemann Susanne , Chakroun Karima , Acevedo-Morantes Claudia Y. , Wille Holger , Tatzelt Jörg , Glatzel Markus 
Published: April 2016

AbstractMisfolding of proteins in the biosynthetic pathway in neurons may cause disturbed protein homeostasis and neurodegeneration. The prion protein (PrPC) is a GPI-anchored protein that resides at the plasma membrane and may be misfolded to PrPSc leading to prion diseases. We show that a deletion in the C-terminal domain of PrPC (PrPΔ214–229) leads to partial retention in the secretory pathway causing a fatal neurodegenerative disease in mice that is partially rescued by co-expression of PrPC. Transgenic (Tg(PrPΔ214–229)) mice show extensive neuronal loss in hippocampus and cerebellum and activation of p38-MAPK. In cell culture under stress conditions, PrPΔ214–229 accumulates in the Golgi apparatus possibly representing transit to the Rapid ER Stress-induced ExporT (RESET) pathway together with p38-MAPK activation. Here we describe a novel pathway linking retention of a GPI-anchored protein in the early secretory pathway to p38-MAPK activation and a neurodegenerative phenotype in transgenic mice.
Au-Ag-Cu nano-alloys: tailoring of permittivity
Authors: Hashimoto Yoshikazu , Seniutinas Gediminas , Balčytis Armandas , Juodkazis Saulius , Nishijima Yoshiaki 
Published: April 2016

AbstractPrecious metal alloys enables new possibilities to tailor materials for specific optical functions. Here we present a systematic study of the effects of a nanoscale alloying on the permittivity of Au-Ag-Cu metals at 38 different atomic mixing ratios. The permittivity was measured and analyzed numerically by applying the Drude model. X-ray diffraction (XRD) revealed the face centered cubic lattice of the alloys. Both, optical spectra and XRD results point towards an equivalent composition-dependent electron scattering behavior. Correlation between the fundamental structural parameters of alloys and the resulting optical properties is elucidated. Plasmonic properties of the Au-Ag-Cu alloy nanoparticles were investigated by numerical simulations. Guidelines for designing plasmonic response of nano- structures and their patterns are presented from the material science perspective.
Competition between global and local online social networks
Authors: Kleineberg Kaj-Kolja , Boguñá Marián 
Published: April 2016

AbstractThe overwhelming success of online social networks, the key actors in the Web 2.0 cosmos, has reshaped human interactions globally. To help understand the fundamental mechanisms which determine the fate of online social networks at the system level, we describe the digital world as a complex ecosystem of interacting networks. In this paper, we study the impact of heterogeneity in network fitnesses on the competition between an international network, such as Facebook and local services. The higher fitness of international networks is induced by their ability to attract users from all over the world, which can then establish social interactions without the limitations of local networks. In other words, inter-country social ties lead to increased fitness of the international network. To study the competition between an international network and local ones, we construct a 1:1000 scale model of the digital world, consisting of the 80 countries with the most Internet users. Under certain conditions, this leads to the extinction of local networks; whereas under different conditions, local networks can persist and even dominate completely. In particular, our model suggests that, with the parameters that best reproduce the empirical overtake of Facebook, this overtake could have not taken place with a significant probability.
Incommensurate spin correlations in highly oxidized cobaltates La2−xSrxCoO4
Authors: Li Z. W. , Drees Y. , Kuo C. Y. , Guo H. , Ricci A. , Lamago D. , Sobolev O. , Rütt U. , Gutowski O. , Pi T. W. , Piovano A. , Schmidt W. , Mogare K. , Hu Z. , Tjeng L. H. , Komarek A. C. 
Published: April 2016

AbstractWe observe quasi-static incommensurate magnetic peaks in neutron scattering experiments on layered cobalt oxides La2−xSrxCoO4 with high Co oxidation states that have been reported to be paramagnetic. This enables us to measure the magnetic excitations in this highly hole-doped incommensurate regime and compare our results with those found in the low-doped incommensurate regime that exhibit hourglass magnetic spectra. The hourglass shape of magnetic excitations completely disappears given a high Sr doping. Moreover, broad low-energy excitations are found, which are not centered at the incommensurate magnetic peak positions but around the quarter-integer values that are typically exhibited by excitations in the checkerboard charge ordered phase. Our findings suggest that the strong inter-site exchange interactions in the undoped islands are critical for the emergence of hourglass spectra in the incommensurate magnetic phases of La2−xSrxCoO4.
Highly sensitive SnO2 sensor via reactive laser-induced transfer
Authors: Palla Papavlu Alexandra , Mattle Thomas , Temmel Sandra , Lehmann Ulrike , Hintennach Andreas , Grisel Alain , Wokaun Alexander , Lippert Thomas 
Published: April 2016

AbstractGas sensors based on tin oxide (SnO2) and palladium doped SnO2 (Pd:SnO2) active materials are fabricated by a laser printing method, i.e. reactive laser-induced forward transfer (rLIFT). Thin films from tin based metal-complex precursors are prepared by spin coating and then laser transferred with high resolution onto sensor structures. The devices fabricated by rLIFT exhibit low ppm sensitivity towards ethanol and methane as well as good stability with respect to air, moisture, and time. Promising results are obtained by applying rLIFT to transfer metal-complex precursors onto uncoated commercial gas sensors. We could show that rLIFT onto commercial sensors is possible if the sensor structures are reinforced prior to printing. The rLIFT fabricated sensors show up to 4 times higher sensitivities then the commercial sensors (with inkjet printed SnO2). In addition, the selectivity towards CH4 of the Pd:SnO2 sensors is significantly enhanced compared to the pure SnO2 sensors. Our results indicate that the reactive laser transfer technique applied here represents an important technical step for the realization of improved gas detection systems with wide-ranging applications in environmental and health monitoring control.
Coding deficits in hidden hearing loss induced by noise: the nature and impacts
Authors: Song Qiang , Shen Pei , Li Xiaowei , Shi Lijuan , Liu Lijie , Wang Jiping , Yu Zhiping , Stephen Kegan , Aiken Steve , Yin Shankai , Wang Jian 
Published: April 2016

AbstractHidden hearing refers to the functional deficits in hearing without deterioration in hearing sensitivity. This concept is proposed based upon recent finding of massive noise-induced damage on ribbon synapse between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the cochlea without significant permanent threshold shifts (PTS). Presumably, such damage may cause coding deficits in auditory nerve fibers (ANFs). However, such deficits had not been detailed except that a selective loss of ANFs with low spontaneous rate (SR) was reported. In the present study, we investigated the dynamic changes of ribbon synapses and the coding function of ANF single units in one month after a brief noise exposure that caused a massive damage of ribbon synapses but no PTS. The synapse count and functional response measures indicates a large portion of the disrupted synapses were re-connected. This is consistent with the fact that the change of SR distribution due to the initial loss of low SR units is recovered quickly. However, ANF coding deficits were developed later with the re-establishment of the synapses. The deficits were found in both intensity and temporal processing, revealing the nature of synaptopathy in hidden hearing loss.
Unveiling the basis of alkaline stability of an evolved versatile peroxidase
Authors: Sáez-Jiménez Verónica , Acebes Sandra , Garcia-Ruiz Eva , Romero Antonio , Guallar Victor , Alcalde Miguel , Medrano Francisco J. , Martínez Angel T. , Ruiz-Dueñas Francisco J. 
Published: April 2016

A variant of high biotechnological interest (called 2-1B) was obtained by directed evolution of the Pleurotus eryngii VP (versatile peroxidase) expressed in Saccharomyces cerevisiae [García-Ruiz, González-Pérez, Ruiz-Dueñas, Martínez and Alcalde (2012) Biochem. J. 441, 487–498]. 2-1B shows seven mutations in the mature protein that resulted in improved functional expression, activity and thermostability, along with a remarkable stronger alkaline stability (it retains 60% of the initial activity after 120 h of incubation at pH 9 compared with complete inactivation of the native enzyme after only 1 h). The latter is highly demanded for biorefinery applications. In the present study we investigate the structural basis behind the enhanced alkaline stabilization of this evolved enzyme. In order to do this, several VP variants containing one or several of the mutations present in 2-1B were expressed in Escherichia coli, and their alkaline stability and biochemical properties were determined. In addition, the crystal structures of 2-1B and one of the intermediate variants were solved and carefully analysed, and molecular dynamics simulations were carried out. We concluded that the introduction of three basic residues in VP (Lys-37, Arg-39 and Arg-330) led to new connections between haem and helix B (where the distal histidine residue is located), and formation of new electrostatic interactions, that avoided the hexa-co-ordination of the haem iron. These new structural determinants stabilized the haem and its environment, helping to maintain the structural enzyme integrity (with penta-co-ordinated haem iron) under alkaline conditions. Moreover, the reinforcement of the solvent-exposed area around Gln-305 in the proximal side, prompted by the Q202L mutation, further enhanced the stability.