bluuebunny/crossref_metadata_2025_split huggingface dataset:
Projections of Carbon Emission reduction pathways in the Carbon Neutral Process by 2050 in Italy: Gray Model Analysis
Authors: Xu Guangyue , Zhu Ruochen , Zhang Qichan , Bashir Adnan 
Published: October 2024

Abstract

The overuse of fossil energy in industrialization process is a major cause of the frequency of global warming and environmental pollution problems, which seriously threaten the sustainable socio-economic development of Italy and other countries. In response to climate change, Italy has declared a goal of carbon neutrality by 2050. Against this background, this paper selects Italy's carbon emissions from 2011 to 2021 and predicts Italy's future carbon emissions using the GM (1, 1) model. The study results show that Italy's carbon emissions show a decreasing trend, with an average annual rate of change of 1.65% in the process of carbon neutrality. Italy's carbon dioxide emissions will drop to 195.46 million tonnes of carbon dioxide equivalent by 2050, which is about 60.40% lower than the peak in 2005. In addition, according to the capacity of forest carbon sinks, Italy will be able to achieve the carbon neutrality target in 2033. Therefore, this study demonstrates Italy's carbon-neutral promotion strategy and enhances the related carbon-neutral system. It provides some references for other countries, including China, to improve their policy design to promote the green and low-carbon transition of the global economy.
Building Resilient Health Systems in Africa through Improved Leadership, Management, and Governance: An evaluation of Niger's Ministry of Health Transformative Training Program
Authors: Doutchi Mahamadou , Ghousmane Abdoulaye , Zampaligre Fatimata , Moussa Bizo , Ishagh El Khalef , Marc Ouédraogo Talatou , Oumarou Batouré , Harouna Hamidou , Tamuzi Jacques Lukenze , Ndwandwe Duduzile E. , Katoto Patrick D. M. C. , Wiysonge Charles S. , Anya Blanche-Philomene Melanga , Tshikolasoni Manengu Casimir 
Published: October 2024

Abstract

Background Effective leadership within the healthcare sector is imperative to address the evolving challenges faced by Africa, including climate change, pandemics, resource constraints, and a growing population. Moving beyond traditional supervisory roles, transformative leadership, with its focus on empowering and motivating others, is essential. To address this need, the Office of the World Health Organization (WHO) in Niger conducted a transformative training for leadership in health targeting senior officials of the Ministry of Health.Objective In this evaluation study, assessed the impact of the training program, particularly its influence on managing and leading health organizations, teams, and programs, promoting self-leadership, and fostering staff cohesion and solidarity through virtual and face-to-face sessions.Methods This was a descriptive study that used each component of the Leadership for Health Transformation training in Niger from November 2 to 5, 2022.Results Out of 28 participating managers and senior executives, the majority reported a better understanding of their leadership weaknesses and acquired tools to enhance their leadership effectiveness. Notable areas of improvement included listening skills, self-control, self-confidence, feedback exchange, objective clarification, peer coaching, change management, innovation for health transformation, negotiation skills, and a win-win approach.Conclusion Given the crucial role of this leadership training in transforming healthcare in Niger and across Africa, additional training programs are judged necessary in the future to strengthen this sector.
The effect of Bai Tou Weng Soup（BTWS）on the activation of TLR4/NF-κB inflammatory signaling pathway induced by dysbiosis of gut microbiota in UC rats
Authors: Turson Sabaydin , Ma Yun Yun , Zheng Li Hua 
Published: October 2024

Abstract

This study investigates the effect of Bai Tou Weng Soup (BTWS) on the activation of TLR4/NF-κB inflammatory signaling pathway induced by dysbiosis of gut microbiota in UC rats. SD rats were randomly divided into a control group and a model group. A mouse model of acute ulcerative colitis was established by pushing 0.5ml of TNBS solution from the anus. HE staining was used to observe the pathological changes in colon tissue to determine the modeling effect. The results showed that BTWS could repair the physical barrier of colon tissue mucosa in mice with ulcerative colitis, improve local damage to colon tissue, and reduce TNF-α、IL-6 and IL-17A in serum (P < 0.05) decreased the mRNA and protein expression of the TLR4/NF-κB signaling pathway. This study indicates that BTWS has a therapeutic effect on ulcerative colitis rats by regulating the mRNA and protein expression of the TLR4/NF-κB signaling pathway.
Larvicidal effect and mechanism of action of the essential oil and major compound from Piper brachypetiolatum (Piperaceae) against Aedes aegypti (Linnaeus, 1762) larvae, with protection of non-target aquatic animals
Authors: Lima Suelen C. , Oliveira André C. , Costa Maria Luiza L. , Abensur Dayane D. , Andrade Aylane T. dos Santos , Souza Hergen V. , Tavares Cláudia P. S. , Roque Rosemary A. 
Published: October 2024

Abstract

Botanical larvicides like essential oils (EO) and their main compounds extracted from plants, such as those in the Piper species offer eco-friendly approaches to mosquito control on account of promote activity against Culicidae larvae, while demonstrating low toxicity to non-target aquatic animals. This study investigated the mechanism and larvicidal activity of the essential oil from Piper brachypetiolatum and its main compound against Aedes aegypti, as well as the lethal effects on the non-target aquatic organisms Toxorhynchites haemorrhoidalis, Anisops bouvieri, and Diplonychus indicus. The EO was extracted from the leaves of P. brachypetiolatum using the hydrodistillation method, yielding 1.5 ± 0.7%. Gas chromatography analyses revealed the presence of sesquiterpenes (64.70%), oxygenated sesquiterpenes (17.64%), monoterpenes (11.76%), and oxygenated monoterpenes (5.88%). The major compound identified was (E)-nerolidol, comprising 64.32% of the EO. Both EO and (E)-nerolidol exhibited larvicidal activity against A. aegypti, with LC50 values of 15.51 and 9.50 ppm, respectively. They also inhibited AChE activity, with IC50 values of 44.97 and 11.07 ppm, respectively, and induced RONS overproduction (p < 0.05) compared to the positive control, α-cypermethrin. Additionally, EO and (E)-nerolidol showed no lethal effects on T. haemorrhoidalis, A. bouvieri, and D. indicus, with these species exhibiting 100% survival after exposure. In contrast, α-cypermethrin caused 100% mortality in these species. These findings highlight the promising potential of the EO from P. brachypetiolatum and (E)-nerolidol as effective and safe alternatives for controlling A. aegypti larvae.
Control of spatiotemporal activation of organ-specific fibers in the vagus nerve by intermittent interferential current stimulation
Authors: Zanos Stavros , Rossetti Nicolo , Song Weiguo , Schnepel Philipp , Jayaprakash Naveen , Koutsouras Dimitrios , Fichman Marc , Wong Jason , Levy Todd , Elgohary Mohamed , Qanud Khaled , Giannotti Alice , Barbe Mary , Chen Frank , Langereis Geert , Datta-Chaudhuri Timir , Mihajlovic Vojkan 
Published: October 2024

Abstract

Vagus nerve stimulation (VNS) is emerging as potential treatment for several chronic diseases, however, limited control of fiber activation to promote desired effects over side effects restricts clinical translation. Here we describe a new VNS method that relies on intermittent, interferential sinusoidal current stimulation (i2CS) through implanted, multi-contact epineural cuffs. In swine, i2CS elicits specific nerve potentials and end organ responses, distinct from equivalent non-interferential sinusoidal stimulation. Comparing experimental results with anatomical trajectories of nerve fascicles from end organs to the stimulation electrode indicates that i2CS activates organ-specific fascicles rather than the entire nerve. Experimental results and anatomically realistic, physiologically validated biophysical models of the vagus nerve demonstrate that i2CS reduces fiber activation at the focus of interference. Current steering and repetition frequency determine spatiotemporal pattern of vagal fiber activation, allowing tunable and precise control of neural and organ responses. In experiments in a cohort of anesthetized swine, i2CS has improved selectivity for a desired effect, mediated by smaller bronchopulmonary fibers, over a side effect, mediated by larger laryngeal fibers, compared to non-interferential sinusoidal or square pulse VNS.
Robust 3D object recognition based on improved Hough voting
Authors: Sa Jiming , Zhang Xuecheng , Yuan Yuan , Song Yuyan , Ding Liwei , Huang Yechen 
Published: October 2024

Abstract

3D object recognition is a critical task in fields such as computer vision and pattern recognition. Recently, point cloud-based 3D object recognition techniques have been widely applied in areas such as automated grasping, remote sensing, navigation, and medical diagnostics. However, factors such as noise, occlusion, and repetitive patterns in the scene can lead to a large number of incorrect correspondences (mismatches) during the feature matching stage, and generate many erroneous pose transformation hypotheses, which affects the accuracy and efficiency of pose estimation and increases the difficulty of object recognition. To reduce the mismatch rate and improve recognition performance, this paper presents a 3D object recognition method based on an improved Hough voting approach. First, we introduce a mismatch removal algorithm based on point pair feature constraints (PPFC), which uses a matching score to filter high-quality matching subsets. Next, we propose an enhanced Hough voting hypothesis generation algorithm that effectively minimizes reliance on the local reference frame (LRF), allowing for efficient hypothesis generation using only a 2D Hough space. Additionally, we design a hypothesis validation algorithm based on an improved threshold strategy to assess and optimize the generated hypotheses. Experimental results show that our method achieves recognition rates of 100% on the Random Views dataset and 98.40% on the UWAOR dataset, demonstrating superior accuracy compared to existing 3D object recognition methods. This indicates that our approach can effectively identify objects even in the presence of significant occlusion and background interference. Moreover, our method offers high spatial and temporal efficiency, providing a novel and effective solution to the challenges of 3D object recognition.
The structural, electronic, elastic, and optical properties of new double perovskite Cs 2 CdPbI 6 were investigated using a DFT and SCAPS-1D simulation
Authors: GHALEB Mohamed , ARRAR Amina , Ali HADJI Chich , BENDJILALI Hadjer , ZERROUKI Otmane 
Published: October 2024

Abstract

The structural, electronic, optical and elastic properties of the cubic double perovskite Cs2CdPbI6 were calculated using a density functional theory DFT. The calculated values were reported to evaluate the photovoltaic (PV) performance of new device structures using the SCAPS-1D solar cell simulation software. The simulation findings demonstrate that the FTO/ETL/ Cs2CdPbI6/HTL which exhibited an efficiency of 32.06%, Voc = 1.4 V, Jsc = 27.99 mA/cm2 and FF = 81.69% at 300 K temperature. The effect of the absorber and ETL thickness, capacitance–voltage, current density–voltage, and quantum efficiency characteristics, series resistance, shunt resistance was also evaluated for the devices. The results of these simulations provide valuable insight that will be useful in the development of efficient double perovskites solar cells based on Cs2CdPbI6.
Gravidez na adolescência: um desafio para as equipes que atuam na atenção primária à saúde
Authors: Braga Lethicia , Silva Jannaina Sther Leite Godinho , Souza Alessandra da Silva , Silva Eliara Adelino da , Silva Geísa Sereno Velloso da 
Published: October 2024

Introdução: a gravidez na adolescência é um fenômeno complexo e multifacetado que continua a ser um desafio significativo em todo o mundo. Ao analisar as ações em saúde, é importante considerar a necessidade de uma abordagem abrangente, que inclua tanto a prevenção primária quanto a secundária. Metodologia: Realizou-se uma revisão bibliográfica integrativa que teve como objetivo geral conhecer quais ações as equipes de atenção primária saúde desenvolvem para amenizar o grande índice de gestação na adolescência. Resultados e discussão: A análise revelou uma série de estratégias que envolvem programas de educação sexual, serviços de aconselhamento em saúde sexual, contraceptivos e campanhas de conscientização. Considerações finais: A rede de atenção primária é vital para evitar a gravidez na adolescência porque é frequentemente o primeiro local de contato dos jovens com o sistema de saúde. Para gerar melhores resultados, os profissionais de saúde devem ser bem treinados, conscientes das necessidades dos adolescentes e capazes de fornecer informações confiáveis, suporte emocional e contracepção.
Palavras-chave: Enfermagem; Gravidez; Adolescência; Atenção Básica.
Synthesis of 2,4-Bis(trifluoromethyl)benzaldehyde Hybrid Thiosemicarbazones as Prolyl Oligopeptidase Inhibitors for Neurodegenerative Disorders and their In-silico Analysis
Authors: Pasha Anam Rubbab , Ullah Saeed , Halim Sobia Ahsan , Khan Ajmal , Hussain Javid , F. El-kott Attalla , Naseer Muhammad Moazzam , Eltantawy Waleed , Al-Harrasi Ahmed , Shafiq Zahid 
Published: October 2024

Introduction:
Prolyl-specific oligopeptidase (POP), one of the brain's highly expressed
enzymes, is an important target for the therapy of central nervous system disorders,
notably autism spectrum disorder, schizophrenia, Parkinson's, Alzheimer's disease,
and dementia.

Method:
The current study was designed to investigate 2,4-bis(trifluoromethyl) benzaldehyde-
based thiosemicarbazones as POP inhibitors to treat the above-mentioned disorders.
A variety of techniques, such as nuclear magnetic resonance (NMR), mass spectrometry
(MS), and Fourier-transform infrared spectroscopy (FTIR), were used for the structural
confirmation of synthesized compounds. After in-vitro evaluation, all of these compounds
were found to be prominent inhibitors of the POP enzyme (IC50= 10.14 - 41.73 μM).

Result:
Compound 3a emerged as the most active compound (IC50 10.14 ± 0.72 μM) of
the series. The kinetic study of the most active 3a (Ki =13.66 0.0012 μM) indicated competitive
inhibition of the aforementioned enzyme.

Conclusion:
Moreover, molecular docking depicted a noticeable role of thiosemicarbazide
moiety in the binding of these molecules within the active site of the POP enzyme.
Exploring the Mechanism of Centipeda minima in Treating Nasopharyngeal Carcinoma Based on Network Pharmacology
Authors: Huang Can , Liu Xiaolin , Wang Weimo , Guo Zhen 
Published: October 2024

Background:
Centipeda minima (CM) is a traditional Chinese herbal medicine used for
the treatment of sinusitis and rhinitis, and it possesses anti-cancer properties. However, the mechanism
of CM in the treatment of nasopharyngeal carcinoma (NPC) remains unclear.

Objective:
This study aimed to explore the mechanism of CM in the treatment of NPC using a network
pharmacology approach.

Methods:
The active components and targets of CM and NPC were screened using TCMSP, SwissTarget,
and GeneCards database. The association between CM components and NPC targets or
pathways was analyzed using String, Cytoscape 3.9.1, David 6.7, and AutoDock Vina. The
Sangerbox platform was used to conduct differential expression and Kaplan-Meier survival analysis
of core genes.

Results:
We identified 17 active compounds of CM and 146 corresponding targeted proteins in
NPC. These targets may modulate pathways in cancer, PI3K-Akt, apoptosis, prolactin, relaxin,
and TNF signaling. The top 5 core genes of the PPI network were found to be AKT1, STAT3,
CASP3, EGFR, and SRC, which may be the main targets of CM in treating NPC. Molecular docking
confirmed the binding energies of quercetin with CASP3, 8-Hydroxy-9,10-diisobutyryloxythymol
with AKT1, and plenolin with AKT1, which were particularly low, suggesting robust and stable
interactions. The expression levels of AKT1, CASP3, EGFR, SRC, MMP9, CCND1, and PTGS2
were significantly higher in head and neck squamous cell carcinoma (HNSC) samples compared
to normal samples. In addition, the hub genes could predict the prognosis of HNSC as the
Kaplan-Meier survival curve showed that patients with lower expressions of AKT1, STAT3,
CASP3, EGFR, MMP9, ESR1, PTGS2, and PPARG had better overall survival.

Conclusion:
By conducting a network pharmacology approach, we revealed the main ingredients,
key targets, and regulatory pathways of Centipeda minima in the treatment of NPC.
Comparison of the Effects of Dill Seed, Grape Seed and Date Extracts on Postpartum Hemorrhage Rates in the Fourth Stage of Labor: A Randomized Clinical Trial
Authors: Shayan Arezoo , Refaei Mansoureh , Parsapour Hamideh , Masoumi Seyedeh Zahra , Ahmadinia Hassan , Moradkhani Shirin , Sattari Mahtab , Hamoun Minoo 
Published: October 2024

Background:
Postpartum hemorrhage (PPH) is one of the three leading causes
of maternal mortality. Herbal medicine is one of the well-known methods of treatment in the
world.

Objective:
This study was conducted to determine and compare the effect of dates, grape seed
and dill seed extracts on the PPH rate in women in the fourth stage of labor.

Methods:
Two hundred eligible multiparous women visiting the maternity ward in Hamadan for
normal delivery participated in this double-blind parallel-group clinical trial. They were
randomly divided into four 50-member groups of experiment (3 groups) and control (1 group).
The data were collected using a researcher-made questionnaire. In the experimental groups, in
addition to routine care and oxytocin administration, the mothers received a capsule containing
15 mg of dill seeds extract or 20 mg of grape seed extract or 5 g of dates extract immediately
after the delivery, and then their hemorrhage rates were measured one and two hours after
delivery. The control group received routine care, oxytocin, and placebo. Data were analyzed in
SPSS 21.

Results:
The hemorrhage changes in the placebo group were much less than the intervention
groups at 1 and 2 hours after delivery, and the four groups had a significant difference in terms
of hemorrhage in both hours (p <0.001). The overall difference between the dates extract group
and the placebo and grape seed groups was also statistically significant (p <0.05).

Conclusion:
All three extracts of dates, grape seed and dill seeds, especially dates, can be
effective in PPH reduction.
Reconocimiento de la liebre de costados blancos de Tamaulipas (Lepus altamirae E. W. Nelson, 1904) (Lagomorpha: Leporidae) en la localidad tipo, Altamira
Authors: Farías-González Verónica , Balderas-Mancilla Ulises de Jesús , Hernández-Hernández Mauricio , Frías-Morales Bruno , Medrano-Walt María De Los Ángeles , Vázquez-Maldonado Laura Elena , Azuara-Domínguez Ausencio , Gallo-Reynoso Juan Pablo , Ortiz-Guerrero Arturo 
Published: October 2024

La liebre de Altamira fue restaurada al nivel taxonómico de especie como Lepus altamirae en 2019, ya que antes se había reclasificado como una subespecie de la liebre de cola negra, Lepus merriami y, posteriormente Lepus californicus, sin embargo, L. altamirae es una liebre de costados blancos. Las décadas que L. altamirae permaneció como subespecie de la liebre de cola negra restaron visibilidad a la importancia de estudiar la historia de vida y la distribución geográfica de la liebre de costados blancos que habita en la región subtropical del noreste de México. Las poblaciones de las diferentes especies de liebres de costados blancos de Norte América están disminuyendo a lo largo de sus rangos de distribución. Los objetivos del presente trabajo fueron investigar y documentar si L. altamirae subsiste en su localidad tipo. Se realizaron búsquedas bibliográficas y en iNaturalist, entrevistas orales a pobladores locales, y muestreos mediante el método de transecto en línea en terrenos con vegetación del Puerto Industrial de Altamira. Una liebre fue fotografiada y se logró la captura de un ejemplar vivo; ambos individuos se identificaron como L. altamirae por la coloración del pelaje y con ello se constató su presencia en la localidad tipo con nuevos registros desde su descripción taxonómica en 1909. Se propone que es necesario monitorear en forma sistemática a L. altamirae para conocer su distribución actual y el estado de conservación.
Internet-Based Abnormal Chromosomal Diagnosis During Pregnancy Using a Noninvasive Innovative Approach to Detecting Chromosomal Abnormalities in the Fetus: Scoping Review
Authors: Oyovwi Mega Obukohwo Sr , Ohwin Ejiro Peggy , Rotu Rume Arientare , Olowe Temitope Gideon 
Published: October 2024

Background
Chromosomal abnormalities are genetic disorders caused by chromosome errors, leading to developmental delays, birth defects, and miscarriages. Currently, invasive procedures such as amniocentesis or chorionic villus sampling are mostly used, which carry a risk of miscarriage. This has led to the need for a noninvasive and innovative approach to detect and prevent chromosomal abnormalities during pregnancy.

Objective
This review aims to describe and appraise the potential of internet-based abnormal chromosomal preventive measures as a noninvasive approach to detecting and preventing chromosomal abnormalities during pregnancy.

Methods
A thorough review of existing literature and research on chromosomal abnormalities and noninvasive approaches to prenatal diagnosis and therapy was conducted. Electronic databases such as PubMed, Google Scholar, ScienceDirect, CENTRAL, CINAHL, Embase, OVID MEDLINE, OVID PsycINFO, Scopus, ACM, and IEEE Xplore were searched for relevant studies and articles published in the last 5 years. The keywords used included chromosomal abnormalities, prenatal diagnosis, noninvasive, and internet-based, and diagnosis.

Results
The review of literature revealed that internet-based abnormal chromosomal diagnosis is a potential noninvasive approach to detecting and preventing chromosomal abnormalities during pregnancy. This innovative approach involves the use of advanced technology, including high-resolution ultrasound, cell-free DNA testing, and bioinformatics, to analyze fetal DNA from maternal blood samples. It allows early detection of chromosomal abnormalities, enabling timely interventions and treatment to prevent adverse outcomes. Furthermore, with the advancement of technology, internet-based abnormal chromosomal diagnosis has emerged as a safe alternative with benefits including its cost-effectiveness, increased accessibility and convenience, potential for earlier detection and intervention, and ethical considerations.

Conclusions
Internet-based abnormal chromosomal diagnosis has the potential to revolutionize prenatal care by offering a safe and noninvasive alternative to invasive procedures. It has the potential to improve the detection of chromosomal abnormalities, leading to better pregnancy outcomes and reduced risk of miscarriage. Further research and development in this field is needed to make this approach more accessible and affordable for pregnant women.