bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyper-attenuating brain lesions on CT after ischemic stroke and thrombectomy are associated with final brain infarction
Authors: Cabral FB , Castro-Afonso LH , Nakiri GS , Monsignore LM , Fábio SRC , dos Santos AC , Pontes-Neto OM , Abud DG 
Published: September 2017

Purpose Hyper-attenuating lesions, or contrast staining, on a non-contrast brain computed tomography (NCCT) scan have been investigated as a predictor for hemorrhagic transformation after endovascular treatment of acute ischemic stroke (AIS). However, the association of hyper-attenuating lesions and final ischemic areas are poorly investigated in this setting. The aim of the present study was to assess correlations between hyper-attenuating lesions and final brain infarcted areas after thrombectomy for AIS. Methods Data from patients with AIS of the anterior circulation who underwent endovascular treatment were retrospectively assessed. Images of the brain NCCT scans were analyzed in the first hours and late after treatment. The hyper-attenuating areas were compared to the final ischemic areas using the Alberta Stroke Program Early CT Score (ASPECTS). Results Seventy-one of the 123 patients (65.13%) treated were included. The association between the hyper-attenuating region in the post-thrombectomy CT scan and final brain ischemic area were sensitivity (58.3% to 96.9%), specificity (42.9% to 95.6%), positive predictive values (71.4% to 97.7%), negative predictive values (53.8% to 79.5%), and accuracy values (68% to 91%). The highest sensitivity values were found for the lentiform (96.9%) and caudate nuclei (80.4%) and for the internal capsule (87.5%), and the lowest values were found for the M1 (58.3%) and M6 (66.7%) cortices. Conclusions Hyper-attenuating lesions on head NCCT scans performed after endovascular treatment of AIS may predict final brain infarcted areas. The prediction appears to be higher in the deep brain regions compared with the cortical regions.
Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): A multicenter, randomized, controlled study
Authors: Campbell Bruce CV , Mitchell Peter J , Churilov Leonid , Yassi Nawaf , Kleinig Timothy J , Yan Bernard , Dowling Richard J , Bush Steven J , Dewey Helen M , Thijs Vincent , Simpson Marion , Brooks Mark , Asadi Hamed , Wu Teddy Y , Shah Darshan G , Wijeratne Tissa , Ang Timothy , Miteff Ferdinand , Levi Christopher , Krause Martin , Harrington Timothy J , Faulder Kenneth C , Steinfort Brendan S , Bailey Peter , Rice Henry , de Villiers Laetitia , Scroop Rebecca , Collecutt Wayne , Wong Andrew A , Coulthard Alan , Barber PA , McGuinness Ben , Field Deborah , Ma Henry , Chong Winston , Chandra Ronil V , Bladin Christopher F , Brown Helen , Redmond Kendal , Leggett David , Cloud Geoffrey , Madan Anoop , Mahant Neil , O’Brien Bill , Worthington John , Parker Geoffrey , Desmond Patricia M. , Parsons Mark W , Donnan Geoffrey A , Davis Stephen M 
Published: September 2017

Background and hypothesis Intravenous thrombolysis with alteplase remains standard care prior to thrombectomy for eligible patients within 4.5 h of ischemic stroke onset. However, alteplase only succeeds in reperfusing large vessel arterial occlusion prior to thrombectomy in a minority of patients. We hypothesized that tenecteplase is non-inferior to alteplase in achieving reperfusion at initial angiogram, when administered within 4.5 h of ischemic stroke onset, in patients planned to undergo endovascular therapy. Study design EXTEND-IA TNK is an investigator-initiated, phase II, multicenter, prospective, randomized, open-label, blinded-endpoint non-inferiority study. Eligibility requires a diagnosis of ischemic stroke within 4.5 h of stroke onset, pre-stroke modified Rankin Scale≤3 (no upper age limit), large vessel occlusion (internal carotid, basilar, or middle cerebral artery) on multimodal computed tomography and absence of contraindications to intravenous thrombolysis. Patients are randomized to either IV alteplase (0.9 mg/kg, max 90 mg) or tenecteplase (0.25 mg/kg, max 25 mg) prior to thrombectomy. Study outcomes The primary outcome measure is reperfusion on the initial catheter angiogram, assessed as modified treatment in cerebral infarction 2 b/3 or the absence of retrievable thrombus. Secondary outcomes include modified Rankin Scale at day 90 and favorable clinical response (reduction in National Institutes of Health Stroke Scale by ≥8 points or reaching 0–1) at day 3. Safety outcomes are death and symptomatic intracerebral hemorrhage. Trial registration ClinicalTrials.gov NCT02388061
Setting the Stage: A Comparative Analysis of an Onstage/Offstage and a Linear Clinic Modules
Authors: Freihoefer Kara , Kaiser Len , Vonasek Dennis , Bayramzadeh Sara 
Published: September 2017

Objective: The purpose of this study was to understand how two different ambulatory design modules—traditional and onstage/offstage—impact operational efficiency, patient throughput, staff collaboration, and patient privacy. Background: Delivery of healthcare is greatly shifting to ambulatory settings because of rapid advancement of medicine and technology, resulting in more day procedures and follow-up care occurring outside of hospitals. It is anticipated that outpatient services will grow roughly 15–23% within the next 10 years (Sg2, 2014). Nonetheless, there is limited research that evaluates how the built environment impacts care delivery and patient outcomes. Method: This is a cross-sectional, comparative study consisted of a mixed-method approach that included shadowing clinic staff and observing and surveying patients. The linear module had shared corridors and publicly exposed workstations, whereas the onstage/offstage module separates patient/visitors from staff with dedicated patient corridors leading to exam rooms (onstage) and enclosed staff work cores (offstage). Roughly 35 hr of clinic staff shadowing and 55 hr of patient observations occurred. A total of 269 questionnaires were completed by patients/visitors. Results: The results demonstrate that the onstage/offstage module significantly improved staff workflow, reduced travel distances, increased communication in private areas, and significantly reduced patient throughput and wait times. However, patients’ perception of privacy did not change among the two modules. Conclusion: Compared to the linear module, this study provides evidence that the onstage/offstage module could have helped to optimize operational efficiencies, staff workflow, and patient throughput.
The Rome IV versus Rome III criteria for heartburn diagnosis: A comparative study
Authors: Zhang Mengyu , Chen Minhu , Peng Sui , Xiao Yinglian 
Published: September 2017

Background The phenotypes of heartburn patients are heterogeneous. Objective The objective of this study was to investigate the proportion of heartburn phenotypes in a Chinese population and to compare the Rome IV and III criteria for heartburn diagnosis. Methods A retrospective study was performed among heartburn patients referred for upper endoscopy and esophageal function tests in a tertiary hospital. Their symptoms fulfilled Rome IV and III criteria. Results A total of 233 patients were included. Fifty-nine patients (25%) were diagnosed with esophagitis, 96 (41%) with non-erosive reflux disease (NERD) and 78 (34%) with functional heartburn (FH) based on Rome III criteria. Approximately 70% of the Rome III NERD patients were changed based on Rome IV criteria, with 36 patients (15%) diagnosed with reflux hypersensitivity (RH) and 32 patients (14%) who didn’t fulfill the criteria considered unclassified. The FH and RH patients showed higher esophagogastric junction-contractile integral (EGJ-CI) and less hiatal hernia than did Rome IV NERD patients. The unclassified had more hiatal hernias than the FH and RH ( p < 0.05). The EGJ-CI was similar between Rome III NERD and FH cases. Conclusion The Rome IV criteria were stricter for heartburn diagnosis and superior in distinguishing NERD from functional disorders on motility patterns than Rome III.
Recovery of Shoulder Rotational Muscle Strength After Arthroscopic Bankart Repair
Authors: Amako Masatoshi , Arino Hiroshi , Tsuda Yoshifumi , Tsuchihara Toyokazu , Nemoto Koichi 
Published: September 2017

Background: Shoulder rotational muscles act as dynamic stabilizers of the glenohumeral joint, and the recovery of muscle strength plays an important role in stabilizing the joint during postoperative rehabilitation. However, temporal changes in muscle strength after arthroscopic Bankart repair have not been clarified. Purpose: To better understand the temporal recovery of shoulder rotational muscle strength after arthroscopic Bankart repair. Study Design: Case series; Level of evidence, 4. Methods: Isokinetic concentric shoulder rotational muscle strength was evaluated in 50 patients who were diagnosed with recurrent dislocations of the glenohumeral joint and treated with arthroscopic Bankart repair. Results: The mean peak torque/weight and total work were reduced significantly at 1.5 months after surgery ( P < .0001) and returned to preoperative levels by 6 months for external rotation and 4.5 months for internal rotation. The contralateral peak torque ratios reached preoperative levels by 6 months after surgery. The ipsilateral peak torque ratios were reduced between 1.5 and 3 months after surgery and returned to preoperative levels at 6 months for external rotation and 4.5 months for internal rotation. Conclusion: Isokinetic shoulder rotational muscle strength after arthroscopic Bankart repair recovered to preoperative levels by 6 months for external rotation and 4.5 months for internal rotation.
Non-destructive, high-content analysis of wheat grain traits using X-ray micro computed tomography
Authors: Hughes Aoife , Askew Karen , Scotson Callum P. , Williams Kevin , Sauze Colin , Corke Fiona , Doonan John H. , Nibau Candida 
Published: September 2017

AbstractBackgroundWheat is one of the most widely grown crop in temperate climates for food and animal feed. In order to meet the demands of the predicted population increase in an ever-changing climate, wheat production needs to dramatically increase. Spike and grain traits are critical determinants of final yield and grain uniformity a commercially desired trait, but their analysis is laborious and often requires destructive harvest. One of the current challenges is to develop an accurate, non-destructive method for spike and grain trait analysis capable of handling large populations.ResultsIn this study we describe the development of a robust method for the accurate extraction and measurement of spike and grain morphometric parameters from images acquired by X-ray micro-computed tomography (μCT). The image analysis pipeline developed automatically identifies plant material of interest in μCT images, performs image analysis, and extracts morphometric data. As a proof of principle, this integrated methodology was used to analyse the spikes from a population of wheat plants subjected to high temperatures under two different water regimes. Temperature has a negative effect on spike height and grain number with the middle of the spike being the most affected region. The data also confirmed that increased grain volume was correlated with the decrease in grain number under mild stress.ConclusionsBeing able to quickly measure plant phenotypes in a non-destructive manner is crucial to advance our understanding of gene function and the effects of the environment. We report on the development of an image analysis pipeline capable of accurately and reliably extracting spike and grain traits from crops without the loss of positional information. This methodology was applied to the analysis of wheat spikes can be readily applied to other economically important crop species.
Myd88 is required for disease development in a primary Sjögren's syndrome mouse model
Authors: Kiripolsky Jeremy , McCabe Liam G , Gaile Daniel P , Kramer Jill M 
Published: September 2017

AbstractSjögren's syndrome (SS) is an autoimmune disease that often results in diminished exocrine gland function. SS patients also experience systemic disease manifestations, including hypergammaglobulinemia and pulmonary and renal pathoses. MyD88 is a ubiquitously expressed adaptor molecule used by all immune cells that is required for IL-1 receptor (IL-1R), IL-18R, and most TLR signaling. The precise role of MyD88 in SS has not been evaluated, although this adaptor is critical for development of lupus, a related autoimmune disease. This study tested the hypothesis that Myd88-mediated signaling is required for local and systemic SS manifestations. To this end, we generated NOD.B10Sn-H2b/J (NOD.B10) mice that are deficient in Myd88 (NOD.B10Myd88−/−). We found that NOD.B10 animals that lack Myd88 show reduced exocrine and extraglandular inflammation. Moreover, these animals are protected from loss of salivary flow. Splenocytes from NOD.B10Myd88−/− mice did not up-regulate activation markers or secrete IL-6 in response to a Myd88-dependent agonist, although BCR signaling remained intact. Finally, IgM, IgG, and anti-nuclear autoantibodies were reduced in NOD.B10Myd88−/− mice compared with the parental strain. These data demonstrate that Myd88 is a crucial mediator of local and systemic SS disease manifestations.
Characterization of buried cables and pipes using electromagnetic induction loop-loop frequency-domain devices
Authors: Thiesson Julien , Tabbagh Alain , Dabas Michel , Chevalier Antoine 
Published: September 2017

The detection and characterization of buried cables and metal pipes has become a key component of field surveys carried out prior to excavation work on construction sites. The very high conductivity and magnetic permeability contrast between any buried cables/pipes compared with the soil makes electromagnetic induction (EMI) instruments very useful for their detection. We have developed a seminumerical method that can be used to model the responses of this type of target. A straight horizontal conductor is equivalent to a series of magnetic dipoles, the magnitude of which can be determined in the spectral domain and then converted back into the spatial domain through the use of an inverse fast Fourier transform. Simulations and case studies allow to establish rules of thumb for the estimation of (1) the nature of the metal: the in-phase response of magnetic cables is of the opposite sign from the conducting ones, (2) the sensitivity to the target characteristic: the influence of the cable/pipe diameter is greater than that of the metal properties, and (3) the depth of the cables. The simulations also underline the role of the coil configuration: Vertical coplanar and perpendicular responses allow a more precise location of the cable/pipe, whereas the horizontal coplanar response is less dependent on the orientation. As ground truth, a known electric cable buried at a depth of 0.5 and 0.002 m in diameter is determined at 0.56 m. The first field test is related to the detection of a buried military cable from World War I, between 2.5 and 3 m below the original ground level. The second field test is related to the detection of a water pipe 0.35 m deep. The modeling technique can be applied to all EMI prospecting methods, and thus it opens the way to the correction of the disturbances generated by cables and pipes.
Long-Term Use of Long-Acting Insulin Analogs and Breast Cancer Incidence in Women With Type 2 Diabetes
Authors: Wu Jennifer W. , Azoulay Laurent , Majdan Agnieszka , Boivin Jean-François , Pollak Michael , Suissa Samy 
Published: September 2017

Purpose The association between long-acting insulin analogs and increased breast cancer risk is uncertain, particularly with the short follow-up in previous studies. We assessed this risk long term in women with type 2 diabetes. Methods A population-based cohort of women 40 years or older, all of whom were treated with long-acting (glargine, detemir) or neutral protamine Hagedorn (NPH) insulin between 2002 and 2012, was formed using the United Kingdom’s Clinical Practice Research Datalink. Women were followed until February 2015 or breast cancer diagnosis. Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) and 95% CIs of incident breast cancer, comparing long-acting insulin analogs with NPH overall, as well as by duration and cumulative dose. Results The cohort included 22,395 women who received insulin treatment, with 321 incident breast cancer events occurring during up to 12 years of follow-up (incidence rate 3.3 per 1,000 person-years). Compared with NPH insulin, insulin glargine was associated with an increased risk of breast cancer (HR, 1.44; 95% CI, 1.11 to 1.85), mainly increasing 5 years after glargine initiation (HR, 2.23; 95% CI, 1.32 to 3.77) and after > 30 prescriptions (HR, 2.29; 95% CI, 1.26 to 4.16). The risk was particularly elevated among prior insulin users (HR, 1.53; 95% CI, 1.10 to 2.12) but not for new users, which included fewer patients and for which one cannot rule out an HR of 1.81. The risk associated with insulin detemir was not significantly elevated (HR, 1.17; 95% CI, 0.77 to 1.77). Conclusion Long-term use of insulin glargine is associated with an increased risk of breast cancer in women with type 2 diabetes. The risk associated with insulin detemir remains uncertain because there are fewer users of this insulin.
Book Reviews
Authors: Lennox Patricia , Taylor Madeline 
Published: September 2017

Designers’ Shakespeare, John Russell Brown and Stephen Di Benedetto (2016)
New York and Oxon: Routledge, 200 pp.,
ISBN: 9780415618007, h/bk, £95, p/bk, £32.99

The Art and Practice of Costume Design, Melissa L. Merz (ed.) (2017)
New York and
London: Routledge, 310 pp.,
ISBN: 9781138828414, p/bk
Awareness raising about protection from sexual abuse in mild mental disabled children parents: Practice sample of an education; Hafif zihinsel engelli çocukların ebeveynlerinde çocuk cinsel istismari konusunda farkındalık yaratma: Eğitim uygulaması örneği
Authors: Küçük Sibel , Platin Nurgün , Erdem Emine 
Published: September 2017

Increasing awareness of the mental disabled children and their families related to sexual abuse could help them in protecting from this experience. This study was conducted to conceive awareness about sexual abuse in mental disabled children families as experimental with pre-post test design. Fifteen mild mental disabled children parents were taken to the study. Data were collected with Parent Interview Form by the researcher. Education for the parents was given with Parents Education Guide Booklets and PowerPoint presentations in 6 sessions. Ethical institute assent and written consents of the parents were taken. For analysis number, percentage and Wilcoxon tests were used.Also, parents' general knowledge scores increase in all educational subjects. İt is determined that there was a statistical difference regarding to the parents’ scores of general knowledge about all education subjects between before and after the education (p<0.05).After the study; the awareness of mental disabled children parents about protecting from a possible sexual abuse were increased as desired with educations about protecting from sexual abuse. Extended English abstract is in the end of PDF (TURKISH) file.ÖzetZihinsel engelli çocukların ailelerinin çocuk cinsel istismarı konusunda farkındalıklarının artması çocuklarının karşılaşabilecekleri olası bir cinsel istismar deneyiminden korunmaları konusunda yardımcı olabilir.Bu araştırma, zihinsel engelli çocukların ebeveynlerinde cinsel istismar konusunda farkındalık yaratmak amacıyla öntest-sontest yarı deneysel desende yapılmıştır. Araştırma 15 hafif zihinsel engelli çocuk sahip ebeveyn ile gerçekleştirilmiştir. Veriler Ebeveyn Görüşme Formu kullanılarak toplanmıştır. Eğitimler Ebeveyn Eğitimi Kılavuz Kitapçıkları ve Sunuları ile 6 eğitim oturumunda gerçekleştirilmiştir. Etik kurul onayı ve ebeveynlerden yazılı bilgilendirilmiş onam formu alınmıştır. Değerlendirmede sayı, yüzdelik ve Wilcoxon testi kullanılmıştır.Ebeveynlerin tüm eğitim konularında genel bilgi puanlarının arttığı ve eğitim öncesi ve sonrası arasında istatistiksel fark olduğu (p<0.05) belirlenmiştir.Araştırma sonucunda; zihinsel engelli çocukların ebeveynlerine verilen cinsel istismardan korunma eğitimleri ile olası bir cinsel istismardan korunmada farkındalıkları istendik yönde arttırılmıştır.
Cross-listed Securities and Multiple Exchange Memberships: Demand Differentiability and Equilibrium Existence
Authors: Faias Marta , Luque Jaime 
Published: September 2017

AbstractThe previous literature on general equilibrium has assumed that all traders belong to a single market. However, traders often participate in more than one exchange to diversify their portfolios. Moreover, there is evidence that the security listings of exchanges overlap. Our model captures these facts: there are multiple exchanges, the same security is listed in different exchanges, and traders can belong to more than one exchange. We show that, in the presence of convex transaction costs, there exists an equilibrium, and that individual demand is a continuously differentiable function in prices.
Using token-based semantic vector spaces for corpus-linguistic analyses: From practical applications to tests of theoretical claims
Authors: Hilpert Martin , Correia Saavedra David 
Published: September 2017

AbstractThis paper presents token-based semantic vector spaces as a tool that can be applied in corpus-linguistic analyses such as word sense comparisons, comparisons of synonymous lexical items, and matching of concordance lines with a given text. We demonstrate how token-based semantic vector spaces are created, and we illustrate the kinds of result that can be obtained with this approach. Our main argument is that token-based semantic vector spaces are not only useful for practical corpus-linguistic applications but also for the investigation of theory-driven questions. We illustrate this point with a discussion of the asymmetric priming hypothesis (Jäger and Rosenbach 2008). The asymmetric priming hypothesis, which states that grammaticalizing constructions will be primed by their lexical sources but not vice versa, makes a number of empirically testable predictions. We operationalize and test these predictions, concluding that token-based semantic vector spaces yield conclusions that are relevant for linguistic theory-building.
Subjunctions as Discourse Markers? About Appropriate Arguments on the Topic ‘Insubordinate Subordination’
Authors: Abraham Werner 
Published: September 2017

AbstractThe present paper is about types of seeming subordination (i.e. subordination by form), which in fact bears all distributional assets of insubordination. Yet, such insubordinate subordination is characterized by sentential autonomy in terms of illocutive force (i.e., it is not only presupposed as subordinates usually are). It will be shown that a reliable diagnostic is provided by the selection of modal particles in the narrow sense, which German and Dutch excel in. It will be illustrated that even the property of matrix V2 as opposed to subordinate Vfinal, otherwise a reliable diagnostic in German and Dutch, are not sufficient conditions for subordination vs. matrix status, sentential presupposition vs. assertive status, and independent (autonomous) illocutive force vs. dependent (inherited) illocutive force. Modal particles play a major diagnostic role in this categorial dichotomy. It will be argued that since formal subordination is an insufficient condition for the separation of formal and notional independence of sentential autonomy the theory of sentence types will have fundamentally to be modified with the main asset of a thorough notional rather than formal definition of sentential autonomy.