bluuebunny/crossref_metadata_2025_split huggingface dataset:
The plasma and peritoneal fluid concentrations of matrix metalloproteinase-9 are elevated in patients with endometriosis
Authors: Liu Haiping , Wang Jianye , Wang Haiyu , Tang Ning , Li Yunfei , Zhang Yan , Hao Tianyu 
Published: January 2016

Background Enzyme matrix metalloproteinase-9 is a member of the matrix metalloproteinase family, which is critical to normal tissue remodelling during embryogenesis and wound healing. In patients with endometriosis, increased expression and activity of matrix metalloproteinase-9 have been observed in ectopic endometrium, but the plasma and peritoneal fluid concentrations of matrix metalloproteinase-9 in patients with endometriosis and their relation to disease severity have not been clear. The aim of the study was to investigate the concentrations of matrix metalloproteinase-9 in plasma and peritoneal fluid of patients with endometriosis. Methods A prospective case–control study was conducted in Jinan Military General Hospital between January 2010 and December 2013. Fifty patients with proven endometriosis and 26 endometriosis-free controls were enrolled in this study. Patients with endometriosis were evaluated and divided into moderate/severe endometriosis group (stage I–II, n = 26) and minimal/mild endometriosis group (stage III–IV, n = 24) according to the revised criteria of the American Society for Reproductive Medicine. Blood samples and peritoneal fluid were obtained from both patients and controls. Matrix metalloproteinase-9 was measured using enzyme-linked immunosorbent assay in plasma and peritoneal fluid. The concentration of matrix metalloproteinase-9 between different groups was compared and its correlation to disease severity was analysed. Results Plasma and peritoneal fluid concentrations of matrix metalloproteinase-9 in patients with endometriosis were higher than that in controls. In addition, those patients with moderate/severe endometriosis had significantly higher plasma and peritoneal fluid concentrations of matrix metalloproteinase-9 compared to those with minimal/mild endometriosis. Matrix metalloproteinase-9 concentrations in plasma and peritoneal fluid were both positively correlated with severity of endometriosis and plasma matrix metalloproteinase-9 concentrations had a positive correlation with peritoneal fluid matrix metalloproteinase-9 concentrations in patients with endometriosis. Conclusions Increased concentrations of plasma and peritoneal fluid concentrations of matrix metalloproteinase-9 appear to be associated with disease severity of endometriosis and may serve as an alternative biomarker to determine disease severity of endometriosis.
Transient human anti-mouse antibody generated with immune enhancement in a carbohydrate antigen 19-9 immunoassay after surgical resection of recurrent cancer
Authors: Nakano Keiichi , Yasuda Keiko , Shibuya Hitoshi , Moriyama Takanori , Kahata Kaoru , Shimizu Chikara 
Published: January 2016

We report a case of transient human anti-mouse antibody from a 64-year-old man in a carbohydrate antigen 19-9 immunoassay using an AIA 1800 analyser that generated immune enhancement after surgical resection of recurrent cancer. Methods The carbohydrate antigen 19-9 concentration was measured using an AIA 1800 analyser and a UniCel Dxl 800. Size-exclusion high-performance liquid chromatography was carried out on a Superose 12 column to estimate the carbohydrate antigen 19-9 elution profile using an AIA 1800 analyser. To determine whether IgM in the patient contributed to the carbohydrate antigen 19-9 immunoassay, immunoprecipitation was performed. Furthermore, mouse immunoglobulins were added to the patient’s serum to verify that the patient’s IgM reacted with it. Results The carbohydrate antigen 19-9 concentration was >400 and 9.5 kU/L using an AIA 1800 analyser and using a UniCel Dxl 800, respectively. In the single carbohydrate antigen 19-9 peak, the molecular weight corresponded to IgM by size-exclusion high-performance liquid chromatography on a Superose 12 column. In the immunoprecipitation reaction and addition of mouse immunoglobulins, there was interference for anti-human IgM and mouse immunoglobulins whose recoveries were 3.2 and 14.2%, respectively. These results indicated that IgM in the patient’s serum interfered with the carbohydrate antigen 19-9 immunoassay using an AIA 1800 analyser. Conclusion A novel transient human anti-mouse antibody generated with immune activation in a carbohydrate antigen 19-9 immunoassay using an AIA 1800 analyser was identified in a patient with rectal cancer after surgical resection. These findings demonstrate the importance of monitoring tumour markers in patients after treatment with mouse monoclonal antibody.
Hidden (end-on) patent ductus arteriosus: recognition and device closure
Authors: Garg Naveen , Madan Bevunahalli Kantharaj 
Published: January 2016

Background Sometimes, it is difficult to visualize a patent ductus arteriosus and deploy a device in the standard lateral view because of an end-on orientation. The right anterior oblique view may be helpful by separating the ductus arteriosus from the aorta. This study was undertaken to evaluate the incidence of end-on patent ductus arteriosus and the utility of the right anterior oblique view during device closure. Methods Aortography was performed in lateral and right anterior oblique views before, during, and after successful device deployment in 117 consecutive patients. When a ductus arteriosus was not clearly visible in the lateral view due to overlapping by the aorta, it was termed “right anterior oblique view useful”. Results The types of patent ductus arteriosus were A, B, C, and E in 86 (73.5%), 20 (17.1%), 4 (3.4%), and 7 (6.0%) patients, respectively. An end-on ductus arteriosus was present in 24 (20.5%) patients (14 type B, 10 type A). The right anterior oblique view was useful during device closure in 15 (12.8%) cases (all end-on type). Among all cases of end-on patent ductus arteriosus, it was useful in 62.5% (most type B and a few type A). In all of these, the device appeared obliquely oriented and foreshortened in the lateral view but fully profiled in the right anterior oblique view. Conclusions Recognizing an end-on patent ductus arteriosus and utilizing the right anterior oblique view simplified device closure. For ducts well-profiled in the lateral view, the right anterior oblique view is unnecessary and avoidable.
Ecological momentary assessment of the relationship between headache pain intensity and pain interference in women with migraine and obesity
Authors: Thomas J Graham , Pavlovic Jelena , Lipton Richard B , Roth Julie , Rathier Lucille , O’Leary Kevin C , Buse Dawn C , Evans E Whitney , Bond Dale S 
Published: January 2016

Background While pain intensity during migraine headache attacks is known to be a determinant of interference with daily activities, no study has evaluated: (a) the pain intensity-interference association in real-time on a per-headache basis, (b) multiple interference domains, and (c) factors that modify the association. Methods Participants were 116 women with overweight/obesity and migraine seeking behavioral treatment to lose weight and decrease headaches in the Women’s Health and Migraine trial. Ecological momentary assessment, via smartphone-based 28-day headache diary, and linear mixed-effects models were used to study associations between pain intensity and total- and domain-specific interference scores using the Brief Pain Inventory. Multiple factors (e.g. pain catastrophizing (PC) and headache management self-efficacy (HMSE)) were evaluated either as independent predictors or moderators of the pain intensity-interference relationship. Results Pain intensity predicted degree of pain interference across all domains either as a main effect (coeff = 0.61–0.78, p < 0.001) or interaction with PC, allodynia, and HMSE ( p < 0.05). Older age and greater allodynia consistently predicted higher interference, regardless of pain intensity (coeff = 0.04–0.19, p < 0.05). Conclusions Pain intensity is a consistent predictor of pain interference on migraine headache days. Allodynia, PC, and HMSE moderated the pain intensity-interference relationship, and may be promising targets for interventions to reduce pain interference.
Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus: a systematic literature review
Authors: Henegar C E , Eudy A M , Kharat V , Hill D D , Bennett D , Haight B 
Published: January 2016

Objective To determine risk factors for progressive multifocal leukoencephalopathy (PML) in systemic lupus erythematosus (SLE) patients, and understand how underlying disease or treatment for SLE may be associated with PML in this population. Methods Studies published in English between January 1, 1984 and October 31, 2014 that reported PML in adult SLE patients were included. Immunosuppression was defined as exposure to ≥1 immunosuppressant drug of interest at PML diagnosis: belimumab, rituximab, mycophenolate mofetil, azathioprine, cyclophosphamide, methotrexate and high-dose corticosteroids (>15 mg/day). Minimal immunosuppression was defined as low-dose corticosteroids (≤15 mg/day) and/or anti-malarials. Results Thirty-five publications met our inclusion criteria: four observational studies, two large case series, and 29 case reports that described 35 cases. Reported PML incidence rates among SLE patients based on observational studies ranged from 1.0 to 2.4 cases/100,000 person-years. Of the 35 case reports, three cases were exposed to no immunosuppressant drugs at PML diagnosis, five cases had minimal immunosuppression, 23 cases had immunosuppression, and four cases were indeterminate. Conclusions The evidence from this literature review suggests that, while PML is a very rare disease in SLE patients, there does appear to be an increased risk of PML associated with SLE compared to the general population, potentially due to immunosuppression, other contributing factors in their underlying disease, treatments prescribed to manage disease, or some combination of these factors. Additional large observational studies, designed to assess exposure to drugs of interest and complicated treatment histories, are needed to provide further evidence about potential mechanisms contributing to the onset of PML in SLE patients.
Indications in Music Therapy: Evidence from Assessment That Can Identify the Expectations of Music Therapy as a Treatment for Autistic Spectrum Disorder (ASD); Meeting the Challenge of Evidence Based Practice
Authors: Møller Anne Steen , Odell-Miller Helen , Wigram Tony 
Published: January 2016

When children with Autistic Spectrum Disorder (ASD) are assessed in music therapy, significant strengths, potentials and resources emerge that may remain hidden in other, more formalised assessments. Therefore, it is becoming more necessary to develop a systematic method of describing this responsiveness, in order to define the expectations of therapy. Music therapy is a particularly important intervention for children with ASD to engage and nurture their capacity for flexibility, creativity, variability and tolerance of change, in order to balance the more structured and behaviourally driven education that is currently popular. The potential of treatment can be defined within the context of meeting healthcare needs. A case study will illustrate a model for defining ‘expectations of therapy’, by drawing on one child's awakened capacity for interaction through shared, improvised music-making. This article includes a long appendix providing an evidence-based review and recommendations regarding assessment and referral criteria based on current research and clinical evidence.
Music Therapy References Relating to Cancer and Palliative Care
Authors: Aldridge David 
Published: January 2016

Hospitals and clinics worldwide have incorporated music therapy in their work with cancer patients and in palliative care. As the music therapy profession has developed internationally, so has its role in palliative care. The arts and creative arts therapies are being seen as a form of spiritual care in healthcare settings, particularly where individuals are confronting life-threatening illnesses. By offering opportunities to engage in the arts and develop creative expression, people with cancer can be enabled to mourn, grieve, celebrate life, be empowered to endure their situation, and find healing and meaning. In many studies we find that music therapy is not simply used with the identified patients but also with their families and carers. As well as noting the importance of work with patients and their families, music therapists also emphasise the importance of music for their own healing. This is necessary to meet personal needs when working with the dying and in the context of a broader hospital milieu of colleagues and friends. The World Health Organisation's recommendations for cancer relief and palliative care are to affirm life and regard dying as a normal process, to provide relief from pain and distressing symptoms, to integrate the psychological and spiritual aspects of patient care, to offer a support system to help patients as actively as possible until death, and to offer a support system to help the family cope during the illness and in their own bereavement. Music therapy has the potential to meet all of these recommendations.
An Investigation into Short-Term Music Therapy with Mothers and Young Children
Authors: Oldfield Amelia , Adams Malcolm , Bunce Lucy 
Published: January 2016

This paper describes an outcome investigation into two clinical groups of mothers and young children receiving short-term music therapy. The first group was a closed group of mothers and toddlers receiving six-weekly music therapy sessions. The second group was an ongoing group of parents and babies receiving one music therapy session followed by a discussion of videotaped excerpts of this music therapy session a week later. As a point of comparison, a group of children and parents attending a local nursery school receiving six-weekly music sessions run by a music therapist was also investigated. Video analyses, audio analyses and parent's questionnaires were used to measure results. Comparing information collated from the questionnaires to results of the video analyses revealed that parents attending the clinical group viewed their children's behaviours in a less positive light than control group parents. The article is written from the music therapist's viewpoint. This group music therapy work is described and reflected upon in a more qualitative way in a previous article entitled ‘“Mummy can play too…” Short-term music therapy with mothers and young children’ published two years ago in the BJMT.
International Interview Series
Authors: Sutton Julie 
Published: January 2016

Expanding on the central theme of this issue, three music therapists give their responses to questions concerning the development of the profession in different areas of Europe. These three views of different aspects of the development of music therapy in a variety of countries place the work of the UK profession into perspective, as well as raising some important further questions for the future. Monika Nöcker-Ribaupierre is based in Germany, leading the music therapy training course in Munich, and is the current General Secretary of the European Music Therapy Confederation; also in this edition we publish a review of her most recent publication Music Therapy for Premature and Newborn Infants (Barcelona Publishers). Tracey Jones works in Dublin and heads the Music Therapy Department at Cheeverstown House. Tracey is an active member of the Irish Association of Creative Arts Therapists (IACAT), an organisation that is involved in new developments in the creative arts therapies professions in Ireland. Claire Flower is the Chair of the British Society for Music Therapy and well-known both in the UK and internationally as a clinician, presenter and author.
The Clinical Application and Relevance of Resource-Oriented Principles in Music Therapy within an International Multicentre Study in Psychiatry
Authors: Mössler Karin , Fuchs Katharina , Heldal Tor Olav , Karterud Inger Marie , Kenner Jason , Næsheim Sissel , Gold Christian 
Published: January 2016

This article is based on an international randomised controlled trial (RCT) in psychiatry investigating the effects of music therapy on difficult to treat psychiatric clients who show a lack of motivation to attend therapy. Previous research has shown that music therapy can be an alternative therapeutic treatment for this client group and this RCT aimed to address this observation. The RCT was a collaboration between music therapists from different therapeutic cultures - Norway, Austria and Australia. Consequently, the music therapy provided was influenced by different training backgrounds. To provide a common methodological basis the therapists also focused on resource-oriented principles. These were especially developed for the study to ensure treatment fidelity, yet first of all have an important impact on the practical work. Five case vignettes depict how different therapists made use of these principles and in which ways these affected the therapeutic process. It will be shown how these principles serve as a methodological tool for reflecting the therapist's attitude towards the client. The relevance of the principles in terms of the establishment of a therapeutic relationship as well as the importance of a resource-oriented focus both in long-term and short-term therapeutic settings is highlighted. Finally, it can be assumed that resource-oriented principles exist at least implicitly throughout music therapeutic cultures and that these emphasise the relationship between therapist and client.
Text Watch
Authors: Strange John 
Published: January 2016

The BJMT Text Watch appears in the second issue of each volume. It aims to raise awareness of music therapy writing outside the principal English language music therapy journals, and to act as a guide to the proliferating literature of our profession. It seeks to draw attention to relevant material from publications that may be less accessible to music therapists, and which therefore might otherwise be overlooked.1 Text Watch includes music therapy and related publications in English that have been published in the current or previous calendar year2- books, chapters, articles, published conference papers and other published media (CD-ROMs, videos, etc). Please note that articles published in English language music therapy journals are listed in Journal Watch (included in the first issue of each volume).
Group Music Therapy on a Dementia Assessment Ward: An Approach to Evaluation
Authors: Melhuish Ruth 
Published: January 2016

This article presents an approach to evaluating a music therapy pilot project carried out on a dementia assessment ward, and introduces the framework for evaluation developed by the music therapist. This framework aims to describe and categorise patients' involvement in sessions, which may help to define clear outcomes for patients. It also highlights the relevance of music therapy treatment to the goals of the multi-disciplinary team on the ward, and to current thinking and policy about dementia care, as described in the National Dementia Strategy (DoH 2009). The project was a collaboration between the local NHS trust (Older Adults Therapies Team), Soundwell Music Therapy Trust and the hospital League of Friends. Soundwell is a specialist mental health music therapy charity, founded in 2002 to provide music therapy and music support groups for mental health service users and unpaid carers in Wiltshire and Bath & North East Somerset (B&NES). A further, extended pilot project is being planned, subject to funding. It is hoped that this will offer the opportunity to trial the evaluation approach more extensively.
Music Therapy with Parkinson's Disease
Authors: Selman Jennie 
Published: January 2016

Disabilities which start in adulthood produce great frustrations as a result of the loss of skills and abilities. These losses have considerable influence on relationships and social skills. Parkinson's Disease patients encounter these problems and the inevitable psychological and emotional problems which they cause. This case study concerns work with a patient using music as a channel for the feelings of frustration. The shared improvised music aids and allows the establishment of a relationship with strong emotional contact and communication.
Music and the Listeners
Authors: Priestley Mary 
Published: January 2016

This paper outlines fourteen sessions of analytical music therapy (Priestley 1975) spread over six months and a follow-up session thirteen weeks later. The client was a self-referred lady psychotherapist aged 60. She had one isolated problem which many sessions of psychotherapy had failed to touch, so in fact this was a focal music therapy. Her problem was that she could not play, or even practise the piano, if she felt anyone (including her teacher) was listening. If she did she had feelings of panic and had to stop. This reduced her playing to the very minimum and naturally hindered her progress and her enjoyment of this art. As she was approaching a more leisured time of life she felt that it was now crucial to try and overcome this anxiety. This paper is based on brief notes made after her sessions and a re-hearing of the recorded improvisations. The client's name and some circumstances have been concealed to preserve confidentiality. She has seen the case study and has given her permission to publish. In order to give the feeling of the inner meaning and emotional flavour of an utterance, words or sentences in quotes are the client's own. Discussion recorded before the improvisation took place before we played. The supervisor mentioned twice is the Jungian analyst, Dr. Redfearn, with whom the writer has discussed her work for several years. The 50-minute sessions were weekly as far as possible, but dates are given.
The Use of Pre-Composed Songs with a Highly Defended Client
Authors: Heal Margaret 
Published: January 2016

This paper illustrates how pre-composed songs which have special meaning for the client can serve as an intermediary phenomenon in psychoanalytically-informed individual music therapy, providing opportunities for the therapist and client to develop shared meanings within the therapeutic boundaries. The client is a teenage boy with moderate learning difficulties who has suffered abuse and deprivation. He is seen as highly defended, presenting an ‘opportunist’ secondary handicap (Sinason 1986) in response to earlier traumas, and as having a limited potential space (Winnicott 1971). Pre-composed songs which had special meaning for him were able to contain his emotions in a structure that was digestible for him. The use of these songs was not seen as a substitute for free improvisation, but as a necessary precursor. After an introduction, the first five music therapy sessions will be described, followed by a conclusion discussing the underlying therapeutic processes. The setting is a secondary special school in north London. Music therapy is the only formal therapy offered for children who have been deprived, neglected, and/or abused, and who struggle with the reality of handicap every day.