bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulating a road map for decarbonization in United States via resource efficiency, renewable energy, and globalization: Evidence from time‐frequency‐quantile approach
Authors: Awosusi Abraham Ayobamiji , Özkan Oktay , Ahmed Zahoor , Sevinç Demet Eroğlu , Adebayo Tomiwa Sunday 
Published: October 2024

AbstractRenewable energy, resource efficiency, and globalization are recognized as pivotal factors in the pursuit of environmental sustainability. This study's novelty lies in examining the impact of resource efficiency, the influence of globalization, and the adoption of renewable energy sources on energy‐related CO2 emissions in the United States spanning the years from 1990 to 2020 is the focus of this study. Additionally, this investigation leveraged a diverse range of time‐frequency‐quantile techniques, encompassing quantile‐on‐quantile regressions, wavelet coherence, cross quantile coherence, wavelet‐based quantile correlation, and quantile regression, which is an additional novel aspect of this study. The findings of this research indicate that resource efficiency, the utilization of renewable energy sources, and the forces of globalization collectively contribute to enhancing ecological sustainability by reducing energy‐related CO2 in the United States across a range of quantiles, time periods, and temporal contexts. The study posits that these findings offer a comprehensive framework that can guide policymakers in the United States toward taking tangible measures to advance ecological sustainability while curbing energy‐related CO2 emissions.
Paraneoplastic neurological syndrome and its impact on the treatment outcomes of small‐cell lung cancer: A single‐center retrospective analysis
Authors: Sato Yuki , Fujiwara Satoru , Shirakawa Chigusa , Hirabayashi Ryosuke , Nagata Kazuma , Nakagawa Atsushi , Tachikawa Ryo , Tomii Keisuke 
Published: October 2024

AbstractIntroductionParaneoplastic neurological syndrome (PNS) is associated with small‐cell lung cancer (SCLC). However, the frequency and characteristics of PNS and the efficacy of anticancer treatment for these patients have not been investigated in the Japanese/Asian population previously. Therefore, we aimed to better understand PNS by evaluating real‐world data from patients with PNS complicated by SCLC.MethodsPatients diagnosed with Stage II–IV SCLC at a single center between August 2007 and April 2021 were retrospectively analyzed. The primary outcome was the incidence of PNS. The secondary outcomes were the change in performance status (PS) after treatment commencement and outcomes following anticancer treatment, including objective response rate (ORR), progression‐free survival (PFS), and overall survival (OS).ResultsA total of 318 patients were evaluated; PNS was present in 2.8% (n = 9) of the overall population. All patients with PNS exhibited poor Eastern Cooperative Oncology Group PS (≥2); moreover, 78% of patients had a PS score of 3–4. An improvement in PS was observed in 56% (n = 5) of patients. Patients with PNS exhibited treatment efficacies similar to patients without PNS (ORR: 89% vs. 83%, p = 1.0; PFS: 7.6 vs. 5.7 months, p = 0.69; OS: not reached vs. 15.6 months, p = 0.23).ConclusionsA total of 2.8% of patients had SCLC complicated by PNS, with poor PS observed. However, anticancer therapy led to an improvement in PS and comparable ORR, as well as PFS and OS similar to those observed in patients without PNS. Thus, anticancer therapy should be considered in patients with PNS.
Feminist visualisation challenges: Methodological innovation, opportunities, and lessons learned
Authors: Coddington Kate , Williams Jill M. 
Published: October 2024

AbstractIn this paper, we detail the process of organising and facilitating a visualisation challenge as part of a larger project centring visual methods. We explore how the visualisation challenge specifically operated to highlight feminist epistemological and methodological principals, and practically, what worked and what didn't. We conclude that visualisation challenges offer exciting potential to jumpstart creative and innovative project development, but if a challenge is to be successful, context matters, and so too do practical and logical considerations. We believe that feminist visualisation challenges offer exciting models to share findings and data, learn from emerging research practices, and build community within and beyond the academy.
Severe cytopenia after chimeric antigen receptor‐T cell driven by large granular lymphocytes and responsive to steroids
Authors: Capes Antoine , Morin Alexandra , Banet Anne , Suner Ludovic , Ricard Laure , Corre Elise , Brissot Eolia , Stocker Nicolas , Marjanovic Zora , Sarkozy Clémentine , Mohty Mohamad , Malard Florent 
Published: October 2024

SummaryImmune effector cell‐associated hematotoxicity (ICAHT) is a common toxicity associated with an important morbidity after chimeric antigen receptor (CAR)‐T‐cell therapy. Multiple factors seem to be involved in the development of severe ICAHT, making its management difficult. Here, we report three cases of severe ICAHT after axicabtagene‐ciloleucel (axi‐cel) for diffuse large B‐cell lymphoma showing an expansion of large granular lymphocyte in the bone marrow with a CD3/CD57‐positive non‐CAR‐T immunophenotype. We show that it is possible to treat them with low‐dose steroids, obtaining a striking resolution of cytopenias with no deleterious impact on the underlying malignancy.
A new face in the treatment of Philadelphia chromosome‐positive acute lymphoblastic leukaemia
Authors: Kondo Takeshi 
Published: October 2024

The prognosis for patients with relapsed/refractory or measurable (minimal) residual disease‐positive Philadelphia chromosome (Ph)‐positive acute lymphoblastic leukaemia (ALL) is poor. Currently, ponatinib is the only approved tyrosine kinase inhibitor (TKI) that is effective for Ph‐positive ALL with the T315I mutation. Although the report by Liu et al. is a retrospective observational study, it offers prospects for the efficacy of chemotherapy combined with the novel third‐generation TKI, olverembatinib, in these conditions, which may be validated in future prospective clinical trials.Commentary on: Liu et al. Efficacy and safety of olverembatinib in adult BCR::ABL1‐positive ALL with T315I mutation or relapsed/refractory disease. Br J Haematol 2024; 205:2228‐2233.
Self‐compassion improves barrier self‐efficacy and subsequently physical activity: A test of longitudinal mediation using a representative sample of the United Kingdom
Authors: Zhang Shuge , Pringle Andy , Roscoe Clare 
Published: October 2024

AbstractIntroductionSelf‐compassion, which directs the awareness of suffering, sympathetic concerns and caring motives towards oneself, is an important psychological quality and resource for health and well‐being. In the context of physical activity, self‐compassion can help individuals overcome obstacles, recuperate from a setback or a lapse and engage in regular physical activity. The present research was the first to examine the longitudinal effects of self‐compassion on physical activity and the mediation role of barrier self‐efficacy of such effects.MethodsWe recruited a national representative sample of 654 UK adults and followed them over three timepoints across 9 months. At each time point, participants completed an online survey assessing levels of state self‐compassion, barrier self‐efficacy and physical activity behaviours. We examined the longitudinal effects of self‐compassion on physical activity and the mediation role of barrier self‐efficacy.ResultsBaseline state self‐compassion consistently correlated with physical activity levels at Times 2 and 3. Barrier self‐efficacy at Time 2 mediated the longitudinal effect of baseline state self‐compassion on Time 3 physical activity, after controlling for within‐ (e.g., Time 1 on Time 2 self‐compassion) and between‐person variations (e.g., covariance of self‐compassion and physical activity within a timepoint).ConclusionsAdopting a self‐compassionate mind facilitates engagement and maintenance of physical activity. Future studies could consider accelerometer‐based physical activity measures and develop and validate a more context‐specific state self‐compassion measure tailored for physical activity contexts. Researchers and practitioners should consider incorporating self‐compassion to future interventions and education programmes for promoting physical activity.
A new way to conceptualize intolerance of uncertainty among adolescents: Embracing the network perspective
Authors: Ye Haoxian , Shi Xinyu , Li Yunyi , Huang Yike , You Ruiyan , Zhang Xiangting , Yu Zhijun , Li Huolian , Fan Fang 
Published: October 2024

AbstractIntolerance of uncertainty (IU), a pivotal transdiagnostic risk factor in psychopathology, is defined as a dispositional incapacity to withstand uncertainty distress, driving maladaptive cognitive, emotional and behavioural reactions to uncertainty. However, the intricate interplay among these components, particularly in adolescents, remains underexplored; yet understanding this interplay is crucial for supporting mental health. To address this gap, we employed a network approach to conceptualize IU in 5672 non‐clinical Chinese adolescents (Mage = 14.13 years, SDage = 1.96 years, range = 10–19 years, 46.6% boys), combining graphical Gaussian models (GGM) and directed acyclic graphs (DAG). Our analyses revealed a tripartite network comprising cognitive, behavioural and emotional components. Notably, ‘frustration’ and ‘work with hindrance’ emerged as key drivers, while ‘catastrophizing belief’ served as a critical bridge linking different components. These findings underscore the importance of alleviating uncertainty‐induced frustration and enhancing coping skills for behavioural impediments to mitigate adolescent IU. Additionally, therapeutic interventions should prioritize modifying and re‐evaluating catastrophizing beliefs related to uncertainty.
Directed Design, Screening and Antiglycation Activity for 3‐Substituted Thiazolium Derivatives, New Analogs of Alagebrium
Authors: Zhukovskaya Olga N. , Kolodina Alexandra A. , Litvinov Roman , Ibragimova Umida , Valuisky Nikita , Sorokina Svetlana , Zhukova Xenia , Pobedinskaya Diana Yu. , Borisov Alexander , Babkov Denis A. , Spasov Alexander A. 
Published: October 2024

ABSTRACTPreliminary ab initio calculations led to the synthesis of novel substituted thiazolium salts, analogs of Alagebrium, which were further explored in vitro for their potential as inhibitors of the glycation reaction utilizing three distinct assays: inhibition of fluorescent AGEs formation, anticrosslinking, and deglycation. Despite the unidirectionality of the assays, distinct differences were observed in the mechanisms of interference and activity manifestation by the compounds. The gathered data permitted the formation of hypotheses about the molecular fragments of the studied antiglycators that are of utmost significance in each assay, thereby guiding future design endeavors. Potential mechanisms of actions are discussed therein. The compound 4‐meth‐yl‐3‐[2‐(4‐methylbiphenyl‐4‐yl)‐2‐oxoethyl] thiazolium bromide displayed high activity across all three assays, establishing it as a lead compound. The cytotoxicological properties of the compounds were evaluated using LDH and MTT assays. However, the lead compound exhibited cytotoxicity, indicating the need for additional investigations aimed at decreasing toxicity while maintaining activity. The targeted thiazolium salts were synthesized through an N‐alkylation reaction between the corresponding thiazoles and phenacyl bromides.
Novel Synthesized Benzophenone Thiazole Hybrids Exhibited Ex Vivo and In Silico Anti‐Inflammatory Activity
Authors: Leão Luiz Paulo Melchior de Oliveira , Neto Albert Katchborian , de Jesus Nicácio Karen , Lavorato Stefânia Neiva , Leite Fernanda Brito , Teixeira Karina Camargo , Murgu Michael , de Paula Ana Cláudia Chagas , Soares Marisi Gomes , Chagas‐Paula Daniela Aparecida , Dias Danielle Ferreira 
Published: October 2024

ABSTRACTNovel benzophenone–thiazole hybrids with different substituents were synthesized and evaluated for anti‐inflammatory activity using an ex vivo human whole‐blood assay. All hybrids (3c and 5a–h) showed significant anti‐inflammatory activity via prostaglandin E2 (PGE2) release inhibition. Moreover, 5c (82.8% of PGE2 inhibition), 5e (83.1% of PGE2 inhibition), and 5h (82.1% of PGE2 inhibition) were comparable to the reference drugs. Molecular docking revealed potential preferable binding to the active sites of cyclooxygenase 2 (COX‐2) and microsomal prostaglandin E synthase‐1 (mPGES‐1) enzymes. This study provides the first evidence that benzophenone–thiazole hybrids may also dock in mPGES‐1, a new attractive anti‐inflammatory drug target, besides providing promising ex vivo anti‐inflammatory activity. Thus, the novel hybrids are promising anti‐inflammatory lead compounds and highlight the significance of optimal substituent selection in the design of potent PGE2 inhibitors.
Biallelic PIGM Coding Variant Causes Intractable Epilepsy and Intellectual Disability Without Thrombotic Events
Authors: Heimer Gali , Pode‐Shakked Ben , Marek‐Yagel Dina , Vernitsky Helly , Tzadok Michal , Barel Ortal , Eyal Eran , Ben‐Zeev Bruria , Atzmon Gil , Anikster Yair 
Published: October 2024

ABSTRACTDuring the past two decades, an emerging group of genes coding for proteins involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis are being implicated in early‐infantile epileptic encephalopathy. Amongst these, a hypomorphic promoter mutation in the mannosyltransferase‐encoding PIGM gene was described in seven patients to date, exhibiting intractable absence epilepsy, portal and cerebral vein thrombosis and intellectual disability (ID). We describe here three siblings exhibiting intractable epilepsy and ID, found to harbor a homozygous c.224G>A p.(Arg75His) missense variant in PIGM, which segregated with the disease in the family. The variant is evolutionary conserved, extremely rare in general population databases and predicted to be deleterious. Structural modeling of the PIGM protein and the p.(Arg75His) variant indicates that it is located in a short luminal region of the protein, predicted to be hydrophilic. Functional prediction suggests that the entire local region is sensitive to mutations, with the p.(Arg75His) variant in particular. This is the first report of a PIGM coding variant, and the second variant altogether to be described affecting this gene. This phenotype differs from that of patients with the shared PIGM promoter mutation by lack of thrombotic events and no decrease in PIGM cDNA levels or CD59 expression on red blood cells.
The Decontamination Effect of an Oscillating Chitosan Brush Compared With an Ultrasonic PEEK‐Tip: An In Vitro Study Using a Dynamic Biofilm Model
Authors: Khan Sadia Nazir , Ribeiro‐Vidal Honorato , Virto Leire , Bravo Enrique , Nuevo Paula , Koldsland Odd Carsten , Hjortsjö Carl , Sanz Mariano 
Published: October 2024

ABSTRACTObjectivesThis study aimed to assess the effect of an oscillating chitosan brush (OCB) compared with an ultrasonic device with PEEK tip (US‐PEEK) for mechanical implant surface decontamination using an in vitro model combining 3D models and a validated dynamic multispecies biofilm.Materials and MethodsA multispecies biofilm using six bacterial strains (Streptococcus oralis, Veillonella parvula, Actinomyces naeslundii, Fusobacterium nucleatum, Porphyromonas gingivalis, and Aggregatibacter actinomycetemcomitans) was seeded on dental implants with machined and sandblasted, large‐grit and acid‐etched (SLA) surfaces. These were installed in 3D models depicting peri‐implant defect. Mechanical decontamination was performed for 120 s using either an OCB or a US‐PEEK. A negative control group received no treatment. Scanning electron microscopy (SEM) was used to evaluate the bacterial composition and quantitative PCR (qPCR) analyzed the number of each bacterial species [colony‐forming units per milliliter (CFU/mL)].ResultsWell‐structured biofilms with a dense microbial distribution were observed on the negative control implants after 72 h. qPCR following mechanical decontamination showed a scarce bacterial reduction in the OCB group. The US‐PEEK group exhibited a significant decrease in bacterial species compared to both OCB and control groups (p < 0.05). A biofilm removal effect was also observed in the OCB group for the machined implant surfaces.ConclusionIn vitro assessment using an anatomical 3D model showed that mechanical decontamination effectively reduced biofilm. The US‐PEEK group demonstrated biofilm reduction on the SLA surface, while the OCB group showed a reduction on the machined implant surface. Additionally, the US‐PEEK group demonstrated greater efficacy in reducing bacterial numbers.
Twenty‐five years of addressing cutting‐edge scientific, policy, and regulatory issues through collaboration: The Forum for Collaborative Research
Authors: Schaefer Robin , Ayvaz Alessi , Hoffman Christopher R. , Yann Margot , Rooney Zachary , Leus Mitchell , Mitra Shilpa , Miller Veronica ,   for the Forum for Collaborative Research
Published: October 2024

AbstractDeveloping safe and effective drugs and other medical products is a complex and costly process. Drug development has been, historically, commonly competitive and uncollaborative, and this tendency toward a lack of interaction between stakeholders—the pharmaceutical industry, academia, regulatory agencies, healthcare providers, and communities, among others—can lead to missed opportunities to improve efficiency and, ultimately, public health. The Forum for Collaborative Research was established in 1997 to address current scientific, policy, and regulatory issues in global health through multistakeholder engagement and dialogue. By providing a neutral and safe space for discussion, the Forum's model has impacted how clinical trials in diverse health areas are conducted, supported broader and more equitable clinical trial participation, and accelerated delivery of new drugs. The Forum's focus and directions have shifted over time, and this responsiveness to the needs of the global health community will be critical to ensure that the Forum continues to support collaboration in global health. In this article, we present lessons learned from this innovative model of collaborative research and regulatory science, pioneered by the Forum for over 25 years, including the importance of collective ownership and governance by all stakeholders, and emphasis on common goals and advantages of collaboration.
The Invisible Species: Big Data Unveil Coverage Gaps in the Atlantic Forest Hotspot
Authors: Trindade Weverton C. F. , Marques Márcia C. M. 
Published: October 2024

ABSTRACTAimRapid technological advancements and the biodiversity crisis have motivated efforts to document species before their extinction. However, taxonomic coverage gaps, where certain species are underrepresented in biodiversity databases, can distort our understanding of ecosystems. Here, we quantified how many of the plant species found in a hotspot are invisible, i.e. they would be excluded from studies due to insufficient occurrence data. Additionally, we identified factors influencing the invisibility of species.LocationAtlantic Forest hotspot, Brazil.MethodsWe downloaded and filtered occurrence data from 15,010 plant species from online biodiversity databases. We utilized multiple thresholds, each representing a minimum required number of records, to classify species as “invisible” if their record count fell below these thresholds. We fitted logistic models to estimate how factors such as life form, presence of a vernacular name, geographical distribution, endemism, and year of taxonomic publication influence the odds of species exclusion.ResultsThe proportion of invisible species ranged from 14% when employing simple tools requiring just three records to as high as 64% with more demanding tools requiring at least 60 records. Species with specific characteristics are more prone to invisibility, including non‐tree species, species without vernacular names, species with restricted distributions within Atlantic Forest, endemic species, and species with names published more recently. A significant portion of these invisible species are distributed along the coastline. In contrast, the continental portion of the biome exhibits fewer taxonomic coverage gaps of known species, most likely due to lower rates of new species descriptions.Main ConclusionsCoverage gaps are shaped by the interaction of biological traits, societal preferences, limited technical support, and human activities. Studies relying on distributional data must balance the rigour of filters and thresholds to achieve both geographical reliability and taxonomic coverage, adjusting them to align with each study's specific data and goals.
Heart rate variability biofeedback for critical illness polyneuropathy: a randomized sham‐controlled study
Authors: Sedghi Annahita , Bartels Christoph , Simon Erik , Krause Florian , Arndt Martin , Zsigri Stefan , Barlinn Kristian , Bodechtel Ulf , Penzlin Ana Isabel , Siepmann Timo 
Published: October 2024

AbstractBackground and purposeCritical illness polyneuropathy (CIP) has been linked to neurocardiac dysfunction mediated by autonomic nervous system dysregulation, which increases mortality. We aimed to assess if heart rate variability (HRV) biofeedback could improve neurocardiac function in CIP.MethodsWe randomly allocated (1:1) patients with electrophysiologically confirmed CIP undergoing early inpatient neurological rehabilitation to additional HRV or sham biofeedback over 14 days. We evaluated neurocardiac function via standard deviation of normal‐to‐normal intervals (SDNN) as the primary outcome, as well as HRV frequency domains, sympathetic cutaneous sudomotor and vasomotor functions and disability at baseline, post intervention and 4 weeks later. The study is registered on the German Clinical Trials Register (DRKS00028911).ResultsWe included 30 patients with CIP (40% females, median [interquartile range] age 64.6 [56, 72] years). We observed an increase in SDNN and the predominantly parasympathetic high frequency domain post intervention (ß = 16.4, 95% confidence interval [CI] 0.2, 32.6 [p = 0.047] and ß = 1179.2, 95% CI 119.9, 2158.5 [p = 0.018]), which was sustained at the 4‐week follow‐up (ß = 25.7, 95% CI 6.0, 45.4 [p = 0.011] and ß = 25.7, 95% CI 6.0, 45.4 [p = 0.011]). Patients who underwent HRV biofeedback displayed a higher adjusted Barthel index, indicating less severe disability 4 weeks after the intervention compared to those in the sham group (ß = 23.3, 95% CI 5.5, 41.1 [p = 0.014]). Low frequency and sympathetic skin functions did not differ between groups (p = nonsignificant).ConclusionsOur study provides pilot data suggesting that, in patients with CIP, HRV biofeedback can improve neurocardiac function with a predominant effect on the parasympathetic nervous system and has a beneficial effect on functional recovery.