bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantifying aggregation and change in runoff source in accordance with catchment area increase in a forested headwater catchment
Authors: Egusa Tomohiro , Ohte Nobuhito , Oda Tomoki , Suzuki Masakazu 
Published: May 2016

AbstractThere has been a great deal of research interest regarding changes in flow path/runoff source with increases in catchment area. However, there have been very few quantitative studies taking subscale variability and convergence of flow path/runoff source into account, especially in relation to headwater catchments. This study was performed to elucidate how the contributions and discharge rates of subsurface water (water in the soil layer) and groundwater (water in fractured bedrock) aggregate and change with catchment area increase, and to elucidate whether the spatial variability of the discharge rate of groundwater determines the spatial variability of stream discharge or groundwater contribution. The study area was a 5‐km2 forested headwater catchment in Japan. We measured stream discharge at 113 points and water chemistry at 159 points under base flow conditions. End‐member mixing analysis was used to separate stream water into subsurface water and groundwater. The contributions of both subsurface water and groundwater had large variability below 1 km2. The contribution of subsurface water decreased markedly, while that of groundwater increased markedly, with increases in catchment area. The specific discharge of subsurface water showed a large degree of variability and decreased with catchment area below 0.1 km2, becoming almost constant above 0.1 km2. The specific discharge of groundwater showed large variability below 1 km2 and increased with catchment area. These results indicated that the variabilities of stream discharge and groundwater contribution corresponded well with the variability of the discharge rate of groundwater. However, below 0.1 km2, it was necessary to consider variations in the discharge rates of both subsurface water and groundwater. Copyright © 2016 John Wiley & Sons, Ltd.
Conceptualizing Big Data: Analysis of Case Studies
Authors: Ylijoki Ossi , Porras Jari 
Published: May 2016

SummaryDigitization and the related datafication produce huge amounts of data. Organizations have started to exploit these new data in order to gain benefits. Exploring this ‘big data jungle’ is a new area for both scholars and practitioners, and the experiences of early adopters are valuable. This paper analyses big data use cases described in the academic literature by using computerized content analysis methods. Based on the analysis results, we have conceptualized themes and guidelines of big data in the context of an organization, thus contributing to the emerging research of big data. In addition to the realized benefits, the case studies reveal issues regarding technology, skills, organizational culture and decision‐making processes. The paper also points out several new research avenues, acts as a reference collection to big data case studies found in academic sources, and bridges theory and practice by pointing out several topics that practitioners should consider. Copyright © 2016 John Wiley & Sons, Ltd.
Subjective Well‐Being and Income: A Re‐Examination of Satiation Using the Regression Kink Model With an Unknown Threshold
Authors: Lien Donald , Hu Yue , Liu Long 
Published: May 2016

SummaryA methodological challenge in testing Easterlin's paradox, which states that increasing income fails to boost happiness beyond a satiation point, lies in the determination of this threshold if it exists. In the existing literature, various levels of GDP per capita have been chosen based upon visual inspection of the scatter plots of the data. The estimated income–well‐being gradients are sensitive to the choice of such kink points. We first replicate the results in Stevenson and Wolfers (American Economic Review, Papers and Proceedings 2013; 103(3): 598–604), then apply the methods proposed in Hansen (Journal of Business and Economic Statistics 2016), which estimate the regression kink model with an unknown threshold, to the data in Stevenson and Wolfers () to re‐examine the two modified versions of Easterlin's hypothesis. In most cases, we do not find the existence of any kink point. In the few cases where a kink point is detected, the estimated kink point thresholds are different from those chosen in the previous literature. Overall, we find no evidence of a satiation point, which is in support of Stevenson and Wolfers (). Copyright © 2016 John Wiley & Sons, Ltd.
Synthesis of stiffness‐tunable and cell‐responsive Gelatin–poly(ethylene glycol) hydrogel for three‐dimensional cell encapsulation
Authors: Cao Ye , Lee Bae Hoon , Peled Havazelet Bianco , Venkatraman Subbu S. 
Published: May 2016

AbstractBiosynthetic poly(ethylene glycol) (PEG)‐based hydrogels have been extensively investigated as extracellular matrix (ECM) mimicking gels as they retain the benefits of both ECM (biological cues) and synthetic hydrogels (tunable mechanical properties). In this article, we developed and characterized a new gelatin–PEG (GP) hydrogel that retains the benefits of gelatin and synthetic hydrogels. In this strategy, the thiolation of gelatin was accomplished by reacting with Traut's reagent; the thiolated gelatin was then conjugated to one end of PEG diacrylate (PEGDA) by Michael‐type addition reaction. Two kinds of GP precursors, GP30 and GP60, were synthesized by changing the amount of Traut's reagent, while the weight ratio between thiolated‐gelatin and PEGDA of GP30 and GP60 was 1.451:1 and 0.785:1, respectively. Finally, neonatal human dermal fibroblasts were encapsulated into the hydrogel by cross‐linking the remaining double bonds of precursor under ultraviolet light. These GP hydrogels can encapsulate the fibroblasts in situ with high cell viability. Moreover, the behaviors of cells within the GP hydrogels can be modulated by varying the cross‐linking density of GP hydrogel (storage modulus from 40 to 2000 Pa). In particular, this article showed that a minimum amount of cell‐binding motifs (gelatin >2.30 wt/vol % and 44.0% dry weight percentage) are required for attachment; and appropriate initial rheological and structural properties (storage modulus <∼100 Pa and mesh size >∼150 nm) can accelerate the attachment of cells and improve cell viability. Hence, this mixed‐hydrogel platform allows an easily control hydrogel structure and modulates cell behavior to reconstruct new tissue in the three‐dimensional microenvironments. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2401–2411, 2016.
Validating the Sensitivity of High‐Resolution Melting Analysis for JAK2 V617F Mutation in the Clinical Setting
Authors: Lin Chien‐Yu , Ho Cheng‐Mao , Tamamyan Gevorg , Yang Shu‐Fen , Peng Ching‐Tien , Chang Jan‐Gowth 
Published: May 2016

BackgroundJanus kinase 2 (JAK2) plays an important role in normal hematopoietic growth factor signaling. The detection of the JAK2 V617F mutation (c.1849GNT, GTC → TTC) is crucial for the diagnosis of myeloproliferative neoplasm (MPN) and has become the essential criteria for diagnosis of MPN by the WHO. High‐resolution melt (HRM) curve analysis is a nongel‐based, closed‐tube method, in which PCR amplification and subsequent analysis are sequentially performed in the well, making it more convenient than other scanning methodologies.MethodsWe evaluated JAK2 V617F mutation by HRM. Twenty‐nine patients diagnosed with MPN were examined. We studied the analytical sensitivity of the HRM analysis using real‐time polymerase chain reaction (PCR) for identifying the JAK2 V617F mutation. Additionally, the sensitivity of HRM analysis and allele‐specific PCR (AS‐PCR) assay was compared.ResultsThe JAK2 V617F mutation was successfully discriminated at an abundance of 6% or above in HRM analysis. Both HRM analysis and AS‐PCR showed 100% accuracy with detection limits of 6% and 2.5%, respectively.ConclusionHRM analysis is a fast, simple, reliable, and nonexpensive method for the detection of the JAK2 V617F mutation. However, more validation of the detection limits of HRM analysis should be performed before declaration of the analytic sensitivity of the method.
Serum Metabonomics of Mild Acute Pancreatitis
Authors: Xu Hongmin , Zhang Lei , Kang Huan , Zhang Jiandong , Liu Jie , Liu Shuye 
Published: May 2016

BackgroundMild acute pancreatitis (MAP) is a common acute abdominal disease, and exhibits rising incidence in recent decades. As an important component of systemic biology, metabonomics is a new discipline developed following genomics and proteomics. In this study, the objective was to analyze the serum metabonomics of patients with MAP, aiming to screen metabolic markers with potential diagnostic values.MethodsAn analysis platform with ultra performance liquid chromatography‐high‐resolution mass spectrometry was used to screen the difference metabolites related to MAP diagnosis and disease course monitoring.ResultsA total of 432 endogenous metabolites were screened out from 122 serum samples, and 49 difference metabolites were verified, among which 12 difference metabolites were identified by nonparametric test. After material identification, eight metabolites exhibited reliable results, and their levels in MAP serum were higher than those in healthy serum. Four metabolites exhibited gradual downward trend with treatment process going on, and the differences were statistically significant (P < 0.05).ConclusionMetabonomic analysis has revealed eight metabolites with potential diagnostic values toward MAP, among which four metabolites can be used to monitor the disease course.
Simplified Bernoulli's method significantly underestimates pulmonary transvalvular pressure drop
Authors: Falahatpisheh Ahmad , Rickers Carsten , Gabbert Dominik , Heng Ee Ling , Stalder Aurelien , Kramer Hans‐Heiner , Kilner Philip J. , Kheradvar Arash 
Published: May 2016

PurposeTo determine whether neglecting the flow unsteadiness in simplified Bernoulli's equation significantly affects the pulmonary transvalvular pressure drop estimation.Materials and Methods3.0T magnetic resonance imaging (MRI) 4D velocity mapping was performed on four healthy volunteers, seven patients with repaired tetralogy of Fallot, and thirteen patients with transposition of the great arteries repaired by arterial switch. Pulmonary transvalvular pressure drop was estimated based on two methods: General Bernoulli's Equation (GBE), ie, the most complete form; and Simplified Bernoulli's Equation (SBE), known as 4V2. More than 2300 individual pressure drop measurements were used to compare the simplified and the general Bernoulli's methods. A linear mixed‐effects model was employed for statistical analyses, fully accounting for clustering of observations among the methods and systolic phases.ResultsThe simplified Bernoulli's method systematically underestimated the pressure drop compared to general Bernoulli's method during the entire systolic phase (P < 0.05), including the peak systole, where on average
.ConclusionThe simplified Bernoulli method underestimated the pressure drop during all systolic phases in all the studied subjects. Therefore, it is necessary to take into account the flow unsteadiness for more accurate estimation of the pressure drop. J. Magn. Reson. Imaging 2016;43:1313–1319.
Bias‐corrected data sets of climate model outputs at uniform space–time resolution for land surface modelling over Amazonia
Authors: Moghim Sanaz , McKnight Shawna L. , Zhang Ke , Ebtehaj Ardeshir M. , Knox Ryan G. , Bras Rafael L. , Moorcroft Paul R. , Wang Jingfeng 
Published: May 2016

ABSTRACTDeveloping high‐quality long‐term data sets at uniform space–time resolution is essential for improved climate studies. This article processes the outputs from two global and regional climate models, the Community Climate System Model (CCSM3) and the Regional Climate Model driven by the Hadley Centre Coupled Model (RegCM3). The results are bias‐corrected time series of atmospheric variables corresponding to Intergovernmental Panel on Climate Change (IPCC's) historical (20C3M) and future (A2) climate scenarios over the Amazon Basin. We use a series of simple but effective interpolation approaches to produce hourly climate data sets at 1° by 1° grid cells. A quantile‐based mapping approach is used to reduce the biases of temperature and precipitation in CCSM3 and RegCM3. Adjustments are also made on specific humidity and downwelling longwave radiation to avoid inconsistency between those variables and bias‐corrected temperature values. We also interpolated an already bias‐corrected Parallel Climate Model data set (PCM1) from 3‐hourly to the hourly resolution. The final climate data sets can be used as forcing of ecosystem and hydrologic models to study climate changes and impact assessments over the Amazon Basin.
Stabilisation of red fruit‐based smoothies by high‐pressure processing. Part II: effects on sensory quality and selected nutrients
Authors: Hurtado Adriana , Guàrdia Maria Dolors , Picouet Pierre , Jofré Anna , Ros José María , Bañón Sancho 
Published: May 2016

AbstractBACKGROUNDNon‐thermal pasteurisation by high‐pressure processing (HPP) is increasingly replacing thermal processing (TP) to maintain the properties of fresh fruit products. The resulting products need to be validated from a sensory and nutritional standpoint. The objective was to assess a mild HPP treatment to stabilise red fruit‐based smoothies in a wide (sensory quality and major nutrients) study.RESULTSHPP (350 MPa/ 10 °C/ 5 min) provided ‘fresh‐like’ smoothies, free of cooked‐fruit flavours, for at least 14 days at 4 °C, although their sensory stability was low compared with the TP‐smoothies (85 °C/ 7 min). In HPP‐smoothies, the loss of fresh fruit flavour and reduced sliminess were the clearest signs of sensory deterioration during storage. Furthermore, HPP permitted the higher initial retention of vitamin C, although this vitamin and, to a lesser extent, total phenols, had a higher degradation rate during storage. The content of sugar present was not affected by either processing treatment.CONCLUSIONMild HPP treatment did not alter the sensory and nutritional properties of smoothies. The sensory and nutritional losses during storage were less than might be expected, probably due to the high antioxidant content and the natural turbidity provided by red fruits. © 2016 Society of Chemical Industry
Financial Disclosure in the Travel and Leisure Industry
Authors: Andrikopoulos Andreas , Merika Anna A. , Merikas Andreas G. 
Published: May 2016

AbstractThis study explores the determinants of Internet financial disclosure in the travel and leisure industry. Studying the case of the firms that are listed in the London Stock Exchange, we employ the generalized method of moments in order to investigate the cross‐sectional variation in the quantity of financial information, which is disclosed on corporate websites of travel and leisure firms. We find that disclosure is positively associated with corporate size, financial leverage, concentrated ownership, dual listing and profitability. We also discover that profitability is not only a determinant of financial disclosure in the travel and leisure industry but also its consequence: More profitable firms yield more requests for transparency among their stakeholders, and they also have the necessary resources to respond to these requests. Copyright © 2016 John Wiley & Sons, Ltd.
OCT for Efficient High Quality Laser Welding
Authors: Dupriez Nataliya Deyneka , Truckenbrodt Christian 
Published: May 2016

AbstractHigh requirements for duration and quality of laser welding are the main topics in the line production nowadays, especially in the automotive industry. With acquisition rates up to 100 kHz and microseconds duration capture times, optical coherence tomography (OCT) is a powerful adaptive tool, with a few microns resolution, for real‐time direct non‐contact investigation of material processing. The measurement system used to acquire the workpiece topography enables high accuracy automatic seam tracking, process monitoring and quality assurance (QA), and these functions are executed simultaneously.
iPhos‐PseEvo: Identifying Human Phosphorylated Proteins by Incorporating Evolutionary Information into General PseAAC via Grey System Theory
Authors: Qiu Wang‐Ren , Sun Bi‐Qian , Xiao Xuan , Xu Dong , Chou Kuo‐Chen 
Published: May 2016

AbstractProtein phosphorylation plays a critical role in human body by altering the structural conformation of a protein, causing it to become activated/deactivated, or functional modification. Given an uncharacterized protein sequence, can we predict whether it may be phosphorylated or may not? This is no doubt a very meaningful problem for both basic research and drug development. Unfortunately, to our best knowledge, so far no high throughput bioinformatics tool whatsoever has been developed to address such a very basic but important problem due to its extremely complexity and lacking sufficient training data. Here we proposed a predictor called iPhos‐PseEvo by (1) incorporating the protein sequence evolutionary information into the general pseudo amino acid composition (PseAAC) via the grey system theory, (2) balancing out the skewed training datasets by the asymmetric bootstrap approach, and (3) constructing an ensemble predictor by fusing an array of individual random forest classifiers thru a voting system. Rigorous jackknife tests have indicated that very promising success rates have been achieved by iPhos‐PseEvo even for such a difficult problem. A user‐friendly web‐server for iPhos‐PseEvo has been established at http://www.jci‐bioinfo.cn/iPhos‐PseEvo, by which users can easily obtain their desired results without the need to go through the complicated mathematical equations involved. It has not escaped our notice that the formulation and approach presented here can be used to analyze many other problems in protein science as well.
Repositioning of Endonuclear Receptors Binders as Potential Antibacterial and Antifungal Agents. Eptyloxìm: A Potential and Novel Gyrase B and Cytochrome Cyp51 Inhibitor
Authors: Carrieri Antonio , L'Abbate Maria , Di Chicco Mariangela , Rosato Antonio , Carbonara Giuseppe , Fracchiolla Giuseppe 
Published: May 2016

AbstractA novel class of antibacterial and antifungal agents is here identified by means of dockings and virtual screening techniques. Biological data proved the initial effort, formulated on the structure similarity of nuclear receptors binders with known quinolones or thiazole derivatives, to reposition PPARs agonists as likely bacterial type II topoisomerases inhibitors.
New insights into the potentiation of the first and second phases of the M‐wave after voluntary contractions in the quadriceps muscle
Authors: Rodriguez‐Falces Javier , Place Nicolas 
Published: May 2016

ABSTRACTIntroduction: We investigated the mechanisms underlying the potentiation of the first and second phases of the compound action potential (M‐wave) after conditioning contractions. Methods: M‐waves were evoked in the knee extensors before and after isometric maximal voluntary contractions (MVCs) of 1 s, 3 s, 6 s, 10 s, 30 s, and 60 s. The amplitude, duration, and area of the M‐wave first and second phases were measured during the 10‐min period after each contraction. Results: The magnitude of the M‐wave first phase was enlarged only after MVCs of 30 s and 60 s, whereas the second phase increased after all MVCs, regardless of their duration. The enlargement of the first phase remained for longer than 2 min, whereas the potentiation of the second phase lasted only 20 s. Conclusions: Potentiation of the first phase is the result of fatigue‐induced membrane changes, whereas enlargement of the second phase is probably related to shortening of muscle fascicles. Muscle Nerve 55: 35–45, 2017
Status Rivalry and the Politics of Biculturalism in Contemporary Aotearoa New Zealand
Authors: Levine Hal 
Published: May 2016

Could it be that despite a huge literature spanning decades from many disciplines, a corpus of writing that examines seemingly every twist and turn of a complex situation, we still are missing something basic and fundamental to a proper understanding of contemporary cultural politics in Aotearoa New Zealand? A thing so obvious and omnipresent, that it was characterized long ago in the anthropological literature as the fundamental dynamic of Polynesian culture, and acknowledged even further back by Maori in their ancestral sayings?He tauranga uta, he toka tu moana (a resting place ashore, a firm rock at sea). ‘This metaphor describes the chief whose influence is unchallenged in his territory which extends from the land to the sea’ (Mead and Grove 2003:125). But surely real chiefs, those solid anchoring points, no longer exist as they did before the coming of the Pakeha. Be that as it may, the elements of social organization and associated cultural values of chiefly status continue to resonate in contemporary society. This paper argues that Goldman's concept of status rivalry is that crucial overlooked aspect of cultural politics necessary to a full understanding of what is happening today in the Waitangi Tribunal, Parliament, and so many other places where biculturalism and multiculturalism are debated and discussed, and that it is an aspect of Polynesian culture that has been part of the interrelationship between the Crown and te tangata whenua (the indigenous people) since their first encounters.
Fetal septum primum excursion (SPE) and septum primum excursion index (SPEI) as sonomarkers of fetal anemia: using hemoglobin Bart's fetuses as a study model
Authors: Sirilert Sirinart , Tongprasert Fuanglada , Srisupundit Kasemsri , Luewan Suchaya , Tongsong Theera 
Published: May 2016

AbstractObjectivesThe objectives the study are to evaluate the effectiveness of septum primum excursion (SPE) and SPEI (SPE index, a ratio of SPE to left atrial diameter) in predicting fetal hemoglobin (Hb) Bart's disease and to determine the correlation between Hb levels and SPE/SPEIMethodsThe database of Cardio‐STIC volume datasets (VDSs) of fetuses at risk of Hb Bart's disease at 18 to 22 weeks was assessed. The VDSs were blindly analyzed offline for measurements of SPE and SPEI.ResultsOf 180 VDSs recruited, 44 were acquired from fetuses with Hb Bart's disease, while 136 were derived from unaffected fetuses. SPE and SPEI was inversely correlated with Hb levels (p < 0.0001). The SPE and SPEI were significantly higher in the affected group (4.1 + 1.1 mm vs 3.0 + 0.8 mm and 0.61 + 1.1 vs 0.49.1 + 0.1, respectively). SPE, at cut‐off 1.3 multiple of median, gave a sensitivity and specificity of 75.0% and 72.7%, respectively, but less than a sensitivity (81.4%) and specificity (95.4%) of middle cerebral artery peak systolic velocity.ConclusionsIn anemic fetuses, SPE and SPEI was inversely correlated with Hb level. Additionally, SPE, better than SPEI, may be used as an adjunctive sonographic sign to predict Hb Bart's disease but its accuracy of prediction is not good enough to be used independently or as a diagnostic test. © 2016 John Wiley & Sons, Ltd.