bluuebunny/crossref_metadata_2025_split huggingface dataset:
Turmeric Herbal Remedies Significantly Reduce Dysmenorrhea in Indonesian Adolescents
Authors: Gita Prigi Dewi , Kusumawardani Paramitha Amelia , Hanum Sri Mukhodim Farida , Rosyidah Rafhani 
Published: October 2024

General background: Dysmenorrhea, or menstrual pain, is a condition that disrupts adolescents' daily activities, with prevalence ranging from 16.8% to 81%. It is commonly managed through pharmacological and non-pharmacological approaches. Specific background: High school students frequently experience dysmenorrhea, which can interfere with their school performance and well-being. Various non-pharmacological methods, such as herbal remedies and thermal therapies, have been proposed to alleviate symptoms. Knowledge gap: Despite the prevalence of dysmenorrhea, limited research focuses on the effectiveness of non-pharmacological interventions among high school students in Indonesia. Aims: This study aims to describe the severity of dysmenorrhea and the methods of pharmacological and non-pharmacological management among female students of SMA Dharma Wanita 1 Gedangan. Results: This quantitative descriptive study, involving 46 tenth-grade students, revealed that 67.4% of respondents experienced mild dysmenorrhea. Among non-pharmacological treatments, 69.6% consumed turmeric herbal remedies, 15.2% used warm compresses, and 10.9% applied warming lotions. Novelty: The study highlights that all non-pharmacological methods effectively reduced the severity of dysmenorrhea among the students, with turmeric herbal remedies being the most popular choice. Implications: These findings suggest the need for collaboration between healthcare professionals, educational authorities, and schools to provide health education on dysmenorrhea management for female adolescents.
Highlights:

Prevalence: 67.4% of students had mild dysmenorrhea.
Treatment: 69.6% used turmeric herbal remedies for pain relief.
Recommendation: Promote school-healthcare collaboration for dysmenorrhea management education.

Keywords: Dysmenorrhea, non-pharmacological management, high school students, turmeric herbal remedy, menstrual pain relief
Ensuring Security in Indonesia's Digital Landscape using Electronic Signature Validation
Authors: Santoso Elga Dwiky , Purwaningsih Sri Budi 
Published: October 2024

Abstract: Digital technology enhances communication and transactions, but unauthorized document modifications necessitate secure electronic signatures due to the risk of unauthorized modifications. This research aims to identify electronic signatures compliant with the ITE Law in Indonesia to ensure their legal validity and enforceability. By utilizing a normative research method with a statute approach, this study examines primary sources, including Law No. 11 of 2008 on Electronic Information and Transactions, Ministerial Regulation No. 11 of 2008 on Electronic Certification, and Law No. 71 of 2019 on Electronic Systems and Transactions. The results indicate that electronic signatures must fulfill specific criteria outlined in Article 11 of the ITE Law to be considered legally binding. These criteria require that the data used for the electronic signature is solely associated with the signer and under their control at all times, along with mechanisms to track modifications and identify signers' approval. The novelty of this research lies in its comparative analysis of certified versus non-certified electronic signatures, contributing to a deeper understanding of their legal implications. The implications of this study highlight the necessity for enhanced authentication measures to safeguard the integrity of electronic transactions, ultimately promoting confidence in digital communications and transactions in Indonesia.
Highlights:

Electronic signatures improve security in digital transactions.
Compliance with ITE Law ensures legal validity.
Valid signatures require data control and modification tracking.

Keywords: Electronic Signatures, ITE Law, Legal Validity, Digital Transactions, Indonesia
Nano materials preparation mechanism of planetary ball mill
Authors: Qi Zhanfeng , Zhao Xinshu , Xiuli GUO , ，WANG Shuo , Zhang Hengye 
Published: October 2024

Abstract

Mechanical ball milling is a planetary ball milling process used to prepare nanomaterials, but its preparation mechanism is still not clear. Previous research has focused more on the influence of various operating parameters of the ball mill, with relatively little attention paid to the motion analysis of the milling balls, resulting in a lack of systematic research. In this study, the motion of milling balls during the mechanical ball milling process for nano fly ash materials was analyzed, taking the unique agglomeration phenomenon during ultrafine grinding into account. A grinding rate coefficient was proposed, and a mechanism function for the preparation of nanomaterials using planetary ball milling was constructed, and its main influencing factors were analyzed and experimentally verified. The results indicate that the order of the influence of the three factors is as follows: grinding medium filling rate > ball milling speed > ball milling time. When the grinding particle size is above 1300 nm, the mechanism function can be directly used, while the particle sizes is below 1300 nm, the mechanism function needs to be combined with the agglomeration level for better accuracy. The calculation error is within 5%. The grinding rate coefficient is only related to the material hardness. By experimentally measuring the grinding rate coefficients of different materials, the mechanism function can be applied to guide the theoretical preparation process of the nanomaterials.
A hippocampal astrocytic sequence emerges during learning and memory
Authors: Ramirez Steve , Senne Ryan , Suthard Rebecca , Cao Rui , Monasterio Amy , Ruesch Evan , Buzharsky Michelle , Howard Marc 
Published: October 2024

Abstract

The dorsal hippocampus is a heterogeneous structure with numerous cell types involved in generating and maintaining detailed representations of space and time. Prior work has established that pyramidal cells contribute to these crucial aspects of episodic memory. For example, hippocampal “time cells” encode temporal information through sequential activity. However, the role of non-neuronal cell types are less often explored. In this study, we investigated dorsal hippocampal CA1 astrocytes using one-photon calcium imaging in freely moving animals during a contextual fear conditioning paradigm. To our knowledge, this is the first time a study has successfully performed longitudinal registration of astrocytic cell population using 1p calcium imaging, thus permitting the tracking of a stable population of these cells in freely-moving mice. In response to foot shock, astrocytes generated robust calcium-event sequences with a time-compressed structure akin to canonical hippocampal time cells. Upon re-exposure to the conditioned context, these astrocytic sequences persisted in the absence of shock, maintaining their time-compressed structure. Moreover, astrocytes active on the previous day retained a preserved sequential structure, indicating memory-specific properties. This phenomenon was not observed in a context different from the initial fear conditioning chamber. Taken together, these results present a potentially paradigm-shifting notion that astrocytes play a significant role in the representation of temporal information processing across learning and memory.
The BioSUD Biobank: A genomic resource for Substance Use Disorders in Italy
Authors: Ribatti Raffaella Maria , de Gennaro Luciana , Daponte Alessia , Cozzoli Danilo , Quaranta Maria Rita , Ostuni Angelo , Casanova Margherita , Ariano Vincenza , Leone Vincenzo , Perrone Francesco , Bona Salvatore Della , Lacalamita Angela , De Fazio Salvatore , Lorusso Daniela , Metspalu Mait , Torroni Antonio , Olivieri Anna , Capelli Cristian , Antonacci Francesca , Catacchio Claudia Rita , Ventura Mario , Montinaro Francesco 
Published: October 2024

Abstract

Substance Use Disorders (SUDs) are a significant public health concern with complex etiologies involving genetic, environmental, and psychological factors. Here we present BioSUD, a biobank that, by integrating genomic data with comprehensive phenotypic assessments, including sociodemographic, psychosocial, and addiction-related variables, was developed to investigate the etiology of SUDs within the Southern Italian population. We assessed a cohort of 1,806 participants (1,508 controls and 298 individuals with SUD diagnosis), revealing a marked male predominance in both groups. Genomic analyses of the newly generated genotypes showed a predominantly Southern Italian ancestry for the BioSUD cohort. Moreover, multiple genotype analysis highlights the presence of different ancestries, suggesting a complex history of Southern Italian groups, contributing to a relatively high level of genetic variation that may be not captured by translational studies based on groups with predominantly Northern European ancestries. From a social and psychological perspective, individuals with SUDs exhibited lower socioeconomic status, increased exposure to adverse experiences, and compromised familial and peer relationships relative to controls. These results show that the BioSUD cohort is valuable for studying SUDs-associated complex behavioral traits.
Evaluating gender bias in Large Language Models in long-term care
Authors: Rickman Sam 
Published: October 2024

Abstract

Background: Large language models (LLMs) are being used to reduce the administrative burden in long-term care by automatically generating and summarising case notes. However, LLMs can reproduce bias in their training data. This study evaluates gender bias in summaries of long-term care records generated with two state-of-the-art, open-source LLMs released in 2024: Meta's Llama 3 and Google Gemma.
Methods: Gender-swapped versions of long-term care records for 617 older people from a London local authority were created. Summaries of male and female versions were generated with Llama 3 and Gemma, as well as benchmark models from Meta and Google released in 2019: T5 and BART. Linguistic and inclusion bias was quantified through sentiment analysis, and frequency of words and themes
Results: The benchmark models exhibited some variation in output on the basis of gender. Llama 3 showed no gender-based differences across any metrics. Gemma displayed the most significant gender-based differences. Male summaries focus more on physical and mental health issues. Language used for men was more direct, with women's needs downplayed more often than men's.
Conclusions: Care services are allocated on the basis of need. If women's health issues are underemphasised, this may lead to gender-based disparities in service receipt. LLMs may offer substantial benefits in easing administrative burden. However, the findings highlight the variation in state-of-the-art LLMs, and the need for evaluation of bias in LLMs. Bias across gender and other protected characteristics should be evaluated in LLMs used in long-term care. The methods in this paper provide a practical framework for such evaluations. The code is available on GitHub.
Hydrogen sulfide preserves intestinal barrier repair function through sulfhydration of RPS20 in experimental colitis
Authors: He Xuan , Li Jichang , Huang Zhihao , Xue Baoshuai , Zhu Jing , You Meiyi , Liu Xiaoyun , Wang Xin , Liu Yucun , Chen Shanwen , Wang Pengyuan 
Published: October 2024

Abstract

Patients with ulcerative colitis (UC) have a significantly impaired intestinal barrier. Hydrogen Sulfide (H2S) is a gaseous mediator that makes notable contributions in a variety of diseases, such as reducing inflammatory response in colitis. The experimental content includes the establishment of a mouse DSS-induced colitis model, mouse colon epithelial organoids culture, H&E staining and mass spectrometry analysis. We recognized that exogenous H2S donor-GYY4137 significantly alleviated the symptoms in UC mice models and maintained Minichromosome Maintenance Complex Component 2 (MCM2) expression. CBS knockdown reduced the expression of sulfhydrated Ribosomal protein S20 (RPS20-ssh) and MCM2 in the mouse colon. Cell experiments indicated that the expression of RPS20-ssh, rather than total expression of RPS20, is responsible. Our investigation indicated that CBS-H2S axis increases the sulfhydration level of RPS20, leading to enhanced binding between RPS20 and MCM2 mRNA, thereby promoting intestinal epithelial proliferation. This may provide a new potential therapy for the clinical treatment of colitis.
CdS(en) hybrid nanoparticles supported on Mg(OH)2-MgO mixture. Suitable preparation via a one pot synthesis for the photocatalytic H2 production
Authors: Romero Angela G. , RAVE SANDRA LUCIA RAMIREZ , Hernández-Gordillo Agileo , Rojas-Montoya Ivan D. , Gómez Ricardo 
Published: October 2024

Abstract

CdS(en)/Mg(OH)2-MgO photocatalysts were easily synthesized using a one pot synthesis, and their structural, optical and morphological properties were characterized by X-ray diffraction, UV-vis spectroscopy, FTIR spectroscopy, nitrogen physisorption and scanning electron microscopy (SEM). These supported materials were used as photocatalysts in the hydrogen evolution reaction (HER), using water as the raw material, and methanol as sacrificial molecule under visible (blue) light irradiation. CdS(en)/Mg(OH)2-MgO materials presented high performances in the HER reaction. When Mg(OH)2-MgO support was obtained by ammonia pre-treatment of MgO, an improvement in the electronic-optical and textural properties was observed, resulting in an enhancement in the H2 yields.
Community-level foliar stable carbon isotope is more influenced by leaf functional traits under drought conditions
Authors: Zhang Jinghui , Wang Xu , Bai Yingying , Jiang Shan , Li Kuan , Li Zhiyong , Liu Huamin , Wang Lixin , Wang Yang , Dong Lei , Liang Cunzhu 
Published: October 2024

Abstract

The carbon isotope composition of leaf tissue is an excellent indicator of a plant's intrinsic water use efficiency, providing crucial insights into vegetation dynamics under global climate change. However, in arid and semiarid grassland ecosystems, the factors driving variations in community foliar δ13C values across different steppe types and the extent to which they can be used to monitor changes in community productivity remain unclear. Based on the community-weighted mean foliar δ13C (foliar δ13CCWM) values of meadow steppe, typical steppe, and desert steppe, which are distributed from east to west as water resources decrease in Inner Mongolia grasslands, our study examines the impacts and regulatory pathways of the community-weighted means of leaf functional traits (LFTCWM) and environmental factors on foliar δ13CCWM values and aboveground productivity. Our results show that the foliar δ13CCWM variations are predominantly influenced by environmental factors in meadow and typical steppe areas but by leaf traits in desert steppe areas. Aboveground productivity in Inner Mongolian grasslands is influenced primarily by temperature, and foliar δ13CCWM values can be used to monitor changes in productivity. Our findings are crucial for understanding how plants drive processes in grassland ecosystems and determining the responses of grassland ecosystems to environmental changes.
Hydrodilatation: A Comparison Between Diabetics and Non-Diabetics with Adhesive Capsulitis
Authors: Onggo Jason Derry , Gupta Mehek , Low Eugene , Tan Teong Jin Lester , Lee Keng Thiam , Ho Sean Wei Loong , T Jegathesan 
Published: October 2024

Abstract

Purpose
The primary aim of this retrospective study is to compare the short and medium-term outcomes for shoulder hydrodilatation for treatment of shoulder AC between diabetic and non-diabetic patients, to evaluate if there were better outcomes amongst non-diabetic patients.
Methods
Patients with clinical or radiological diagnosis of AC and who underwent ultrasound guided shoulder hydrodilatation in our local institution from January 2021 to June 2022 were included in this study. Clinical outcomes were measured with visual analog scale (VAS) for pain and passive range of motion consisting of forward flexion (FF) and external rotation (ER) at pre-hydrodilatation, 1-month and 6-months post hydrodilatation.
Results
A total of 163 shoulders were included, corresponding to 156 patients consisting of 47 diabetics, 109 non-diabetics and 7 bilateral shoulders (3 diabetics and 4 non-diabetics). At the time of presentation, there was no significant difference in VAS, FF or ER between diabetics and non-diabetics. From pre-hydrodilatation to 1-month post-hydrodilatation and 1-month to 6-months post-hydrodilatation, there was significant improvement in VAS, FF and ER for both groups. Comparing diabetics vs non-diabetics, the non-diabetic group had significantly better FF (p<0.01) at 1 month post hydrodilatation. At 6 months post-hydrodilatation, non-diabetic group also had significantly better outcomes including VAS score (p=0.02), FF (p<0.01) and ER (p=0.02).
Conclusion
Hydrodilatation is an effective treatment option in the short and medium term in both diabetics and non-diabetics with adhesive capsulitis, with good relief of pain and improvement in shoulder range of motion. Diabetic patients have significantly less improvement in range of motion and pain compared to non-diabetics at 6-months post hydrodilatation.
Clinical Study on Huangqin Decoction in Treating HR-Positive Patients with Abemaciclib-Related Diarrhea - Study Protocol for a Randomized Controlled Trial
Authors: Zhu Mengdie , Wu Chunyu , Liu Sheng 
Published: October 2024

Abstract

Background: Diarrhea is one of the most common adverse drug reactions of Abemaciclib, which severely affects the quality of life of patients. Traditional Chinese medicine has been widely used in the treatment of drug-related diarrhea and has achieved good clinical efficacy. This study aims to evaluate the clinical therapeutic effect of Huangqin Decoction, a classical Chinese medicine formula, on Abemaciclib-related diarrhea.
Methods: This study was designed as a randomized double-blind controlled trial, with two parallel groups. A total of 140 patients aged between 18 and 75 years,diagnosed with HR-positive breast cancer and taking Abemaciclib, were randomly divided into the intervention group and the control group. After enrollment, both groups received 2 months of traditional Chinese medicine treatment, with the experimental group receiving Huangqin Decoction and the control group receiving placebo treatment. The primary outcome measure was the incidence of graded diarrhea, while the secondary outcome measures included diarrhea clinical symptom score,frequency and duration of diarrhea,KPS (Karnofsky Performance Status),safety evaluation index,and the observational indicators are ORR (Overall Response Rate) and PFS (Progression-Free Survival).
Discussion: This study aims to observe the efficacy of Huangqin Decoction in treating Abemaciclib-related diarrhea, providing new treatment ideas and reliable scientific evidence for Abemaciclib-related diarrhea. The impact of Huangqin Decoction on the tumor status of HR-positive breast cancer patients still needs further follow-up.
Trial Registration: Chictr.org.cn Identifier: ChiCTR2400084945. Registered on May 28,2024.
Derivation and Validation of a Clinical Deterioration Early Warning System (Cdews) Score in Hospital Inpatients
Authors: Mas Naia , Legarreta Maria Jose , Molinuevo Janire , García-Gutiérrez Susana , group CDEWS working 
Published: October 2024

Abstract

Electronic health records allow access to data on potential predictors of clinical deterioration in hospital inpatients beyond vital signs, e.g., lab test results and comorbidities. Using such data, we aimed to develop and validate a model to predict clinical deterioration.
A retrospective cohort study was conducted with information on vital signs, comorbidities, and lab test results for consecutive over-17-year-olds hospitalized in Galdakao-Usansolo University Hospital. Deterioration was defined as death or unplanned admission to an intermediate/intensive care unit. A multivariate generalized linear mixed model was constructed using a derivation dataset, adjusting for the random effect of the patient. We calculated risk scores and categories and the area under the receiver operating characteristic curve (AUC) for this cohort, and also for an external validation cohort, to test their validity with external data. The model was calibrated in the derivation dataset considering 10 decile-based groups. The score was calibrated in both datasets.
Overall, 6,372 hospitalizations of 9,084 patients (70.5%) were included in the derivation dataset and 7,812 of 10,531 patients (74.2%) in the validation dataset. In these sets, 5% and 6% of patients respectively reached the composite endpoint (pvalue = 0.02). Older patients, and those with polypharmacy and/or neoplasms were more likely to deteriorate. Deterioration was associated with higher blood pressure and C-reactive protein and lower oxygen saturation, glycemia, and potassium levels. The final model´s AUC was 0.83 (0.81-0.85).
We provide a reliable easy-to-implement score to predict death or unexpected ICU admission; further research is needed to assess potential clinical benefits.
ClinicalTrials.gov ID: NCT06499376Registered at 2024-07-12 (retrospectively registered)
Does Voiding Cystouretrography Cause Thyroid Dysfunction in Pediatric Patients with Chronic Kidney Disease?
Authors: Manyas Hayrullah , Özdemir Özgür Şimşek , Ayrancı İlkay , Erfidan Gökçen , Demir Belde Kasap , Çatlı Gönül , Dündar Bumin Nuri 
Published: October 2024

Abstract

Background
High blood iodine levels have been reported after voiding cystourethrography (VCUG). This excess iodine can cause thyroid hormone disorders, particularly in children with reduced renal clearance.
Objective
We aimed to evaluate the thyroid functions of pediatric patients with chronic kidney disease (CKD) exposed to iodinated contrast media (ICM) during VCUG.
Materials and methods
We retrospectively studied children with CKD who had VCUG between March 2015-March 2019, whose thyroid function tests were within normal limits in last three months before VCUG, and who had thyroid function tests after the exposure. 44 patients were included in the study. 32 CKD patients were in the ICM exposure group, and 12 CKD patients were in the control group.
Results
Seventeen (56%) of 32 cases included in the VCUG group were male. The mean age of patients in this group was 9.4 ± 4.75 years. The median duration time from VCUG to thyroid functions testing was 13 months. There was no statistically significant difference between the thyroid function test results before and after VCUG in terms of fT3 and TSH levels. fT4 levels were significantly reduced after VCUG (p:0.03). Only one patient was diagnosed with subclinical hypothyroidism, and no patient was diagnosed with overt hypothyroidism.
Conclusion
This study demonstrated that overt hypothyroidism did not develop in children with CKD at least six months after ICM exposure during VCUG. A significant decrease in fT4 levels was detected after ICM exposure, indicating that these cases should be followed up in terms of thyroid dysfunctions.