bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐Wide Search for Nonadditive Allele Effects Identifies
PSKH2
as Involved in the Variability of Factor V Activity
Authors: Gendre Blandine , Martinez‐Perez Angel , Kleber Marcus E. , van Hylckama Vlieg Astrid , Boland Anne , Olaso Robert , Germain Marine , Munsch Gaëlle , Moissl Angela Patricia , Suchon Pierre , Souto Juan Carlos , Soria José Manuel , Deleuze Jean‐François , März Winfried , Rosendaal Frits R. , Sabater‐Lleal Maria , Morange Pierre‐Emmanuel , Trégouët David‐Alexandre ,   CHARGE Hemostasis Working Group
Published: October 2024

Background
Factor V (FV) is a key molecular player in the coagulation cascade. FV plasma levels have been associated with several human diseases, including thrombosis, bleeding, and diabetic complications. So far, 2 genes have been robustly found through genome‐wide association analyses to contribute to the inter‐individual variability of plasma FV levels: structural F5 gene and PLXDC2.

Methods and Results

The authors used the underestimated Brown‐Forsythe methodology implemented in the QuickTest software to search for non‐additive genetic effects that could contribute to the inter‐individual variability of FV plasma activity. QUICKTEST was applied to 4 independent genome‐wide association studies studies (LURIC [Ludwigshafen RIsk and Cardiovascular Health Study], MARTHA [Marseille Thrombosis Association], MEGA [Multiple Environmental and Genetic Assessment], and RETROVE [Riesgo de Enfermedad Tromboembolica Venosa]) totaling 4505 participants of European ancestry with measured FV plasma levels. Results obtained in the 4 cohorts were meta‐analyzed using a fixed‐effect model. Additional analyses involved exploring haplotype and gene×gene interactions in downstream investigations. A genome‐wide significant signal at the
PSKH2
locus on chr8q21.3 with lead variant rs75463553 with no evidence for heterogeneity across cohorts was observed (
P
=0.518). Although rs75463553 did not show an association with mean FV levels (
P
=0.49), it demonstrated a robust significant (
P
=3.38x10
−9
) association with the variance of FV plasma levels. Further analyses confirmed the reported association of
PSKH2
with neutrophil biology and revealed that rs75463553 likely interacts with two loci,
GRIN2A
and
POM121L12
, known for their involvement in smoking biology.

Conclusions

This comprehensive approach identifies the role of
PSKH2
as a novel molecular player in the genetic regulation of FV, shedding light on the contribution of neutrophils to FV biology.
Association of Prepregnancy Cardiometabolic Health With Hypertensive Disorders of Pregnancy Among Historically Underrepresented Groups in the United States
Authors: Kwapong Yaa A. , Boyer Theresa , Adebowale Oluwalonimi , Ogunwole S. Michelle , Vaught Arthur Jason , Ndumele Chiadi E. , Hays Allison G. , Blumenthal Roger S. , Michos Erin D. , Selvin Elizabeth , Coresh Josef , Minhas Anum S. 
Published: October 2024

Background
Prepregnancy diabetes and obesity are associated with hypertensive disorders of pregnancy (HDPs). However, the proportion of cases of HDP in the population explained by diabetes and obesity (population attributable fraction), especially among American Indian and Alaska Native and Native Hawaiian and Other Pacific Islander, is not well characterized.

Methods and Results

We conducted a cross‐sectional analysis of data on individuals with a live singleton birth from the US National Vital Statistics System between 2016 and 2019. We used adjusted logistic regression to estimate the prevalence odds ratios of HDPs and tested interaction for race and ethnicity. We calculated the population attributable fraction for the effect of obesity and diabetes on HDPs. Among 13 201 338 birthing individuals, (mean age, 29±6 years), 7% had HDP. The prevalence of HDP was highest among American Indian and Alaska Native individuals (9.1%). Prepregnancy diabetes (prevalence odds ratio, 2.63 [95% CI, 2.59–2.67]) and obesity (prevalence odds ratio, 2.95 [95% CI, 2.93–2.97]) were associated with HDPs. Compared with non‐Hispanic White individuals, the association of diabetes with HDPs was strongest among Native Hawaiian and Other Pacific Islander (prevalence odds ratio, 3.05 [95% CI, 2.48–3.77]), and the association of obesity with HDP was strongest among Asian individuals (prevalence odds ratio, 3.44 [95% CI, 3.35–3.54]; all
P
for interaction <0.05). Population attributable fractions for diabetes and obesity were highest among Native Hawaiian and Other Pacific Islander individuals (diabetes, 3.7% [95% CI, 3.3%–4.0%]; and obesity, 45% [95% CI, 41.9%–47.8%]).

Conclusions
Prepregnancy diabetes and obesity are associated with HDP across all racial and ethnic groups. Diabetes and obesity have highest population attributable fractions among Native Hawaiian and Other Pacific Islander individuals and should be aggressively targeted during childhood, adolescence, and young adulthood to reduce risk of HDPs.
Dose–Response Independent and Joint Associations of Physical Activity and Sedentary Behavior With Mortality Risk in 40 156 Australian Adults With Coronary Heart Disease
Authors: Freene Nicole , Lönn Amanda , Carroll Suzanne , Niyonsenga Theo , Bauman Adrian , Gallagher Robyn , Ding Ding , Davey Rachel 
Published: October 2024

Background
Little is known about the relationship between physical activity (PA) and sedentary behavior (SB) with death in people with coronary heart disease. The aim was to examine the independent and joint associations of PA and SB with death.

Methods and Results
This is a prospective cohort study including Australian participants aged ≥45 years with self‐reported coronary heart disease (2006–2020). Self‐reported PA (min/wk) and SB (h/d) were the exposures. Cardiac and all‐cause death were the main outcomes. The cohort included 40 156 participants (mean age, 70.3 (SD, 10.3) years; 15 278 women [38%]). During a median follow‐up of 11.1 (interquartile range, 6.2–14.4) years, 2497 cardiac and 12 240 all‐cause deaths were recorded. Compared with no PA, a 20% to 30% lower risk of cardiac and all‐cause death was associated with any level of PA. Walking and moderate to vigorous PA at 150 to 300 min/wk was associated with a 43% to 44% lower risk of cardiac death and 35% to 40% lower risk of all‐cause death. Compared with ≥10.5 h/d of SB, participants who were sedentary for 7 to 10.4 h/d experienced an ≈25% reduced associated risk of cardiac and all‐cause death. A 56% associated reduction in all‐cause mortality risk was found if SB was limited to <3.4 h/d. If participants completed >150 min/wk moderate to vigorous PA and spent <7 h/d in SB, the associated risk of cardiac and all‐cause death was reduced by ≈70%.

Conclusions
All people with coronary heart disease should be encouraged to meet the PA guidelines and limit SB to <7 h/d, noting any increase in physical activity and decrease in SB is better than none to prevent premature death.
Trends in Transcatheter Versus Surgical Aortic Valve Replacement Outcomes in Patients With Low‐Surgical Risk: A Systematic Review and Meta‐Analysis of Randomized Trials
Authors: Kazemian Sina , Fallahtafti Parisa , Sharifi Mohammad , Mohammadi Negin Sadat Hosseini , Soleimani Hamidreza , Moghadam Arman Soltani , Karimi Elaheh , Sattar Yaser , Jenab Yaser , Mehrani Mehdi , Hajizeinali Alimohammad , Iskander Mina , Sabet Mehrshad Fathian , Salehi Negar , Al‐Azizi Karim , Hakim Diaa , Alam Mahboob , Hosseini Kaveh 
Published: October 2024

Background
Limited data exist on long‐term outcomes after transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR). This meta‐analysis aims to elucidate outcome trends following TAVR versus SAVR in patients with severe aortic stenosis and low‐surgical risk.

Methods and Results

A systematic search was conducted in PubMed, Embase, Scopus, and the Cochrane Library databases from inception until May 2024, to identify studies comparing TAVR versus SAVR in patients with low‐surgical risk (Society of Thoracic Surgeons predicted risk of mortality score <4%). The primary outcome was all‐cause mortality. Secondary outcomes included cardiovascular mortality, stroke, disabling stroke, rehospitalization, myocardial infarction, aortic valve reintervention, permanent pacemaker implantation, and new‐onset atrial fibrillation. Binary random‐effects models were used to compare the risk of each outcome across various follow‐up intervals and the risk of bias was assessed using the Cochrane Collaboration's Risk of Bias‐2 tool. The meta‐analysis included 6 randomized trials including 4682 patients. TAVR was associated with a lower risk of all‐cause mortality than SAVR in the 30‐day (hazard ratio [HR: 0.45] [95% CI: 0.26–0.77],
I
2
: 0%) and 30‐day to 1‐year (HR: 0.55 [95% CI: 0.37–0.81],
I
2
: 16%) follow‐ups. However, the risk of all‐cause mortality was similar during >1‐year follow‐ups. TAVR was associated with a significantly lower risk of cardiovascular mortality, disabling stroke, rehospitalization, new‐onset atrial fibrillation, and a higher risk of permanent pacemaker implantation compared with SAVR during the 30‐day follow‐up.

Conclusions
TAVR was associated with a lower risk of all‐cause mortality within the first year of post‐procedural follow‐up compared with SAVR. However, the risk of all‐cause mortality was similar in >1‐year follow‐ups.
The Crucible of Family, Money, and Conversion
Authors: Kang Sukhwan 
Published: October 2024

Abstract
This article examines the evolution of the French government’s policy concerning Huguenot mobility by analyzing legal petitions, primarily passport requests, submitted by nouveaux convertis (new converts) and rémigrés (returning Huguenot refugees) from the Revocation period to the Regency of the duke of Orléans. While the French state closely scrutinized the passport applications of nouveaux convertis and rémigrés, local officials increasingly recognized the practicality of easing harsh restrictions on Huguenot mobility to curb their emigration to Protestant countries and their resistance to conversion efforts. Huguenot families also carefully crafted their petitions, strategically considering familial connections, financial concerns, and the necessity of conversion for obtaining passports. The intersection of family, money, and conversion, as manifested through these passport narratives, shows us how interactions between state actors and passport petitioners nudged the government toward a moderation of the severe Revocation policy.
What’s Wrong with Some Having More than Others?
Authors: Hausman Daniel M. 
Published: October 2024

Abstract
According to Derek Parfit, “telic” egalitarians accept “The Principle of Equality,” which says, “It is in itself bad if some people are worse off than others” (1991, p. 4). This essay argues that there is no good reason to believe this principle and considerable reason to doubt it. Either egalitarianism is groundless, or this principle misconstrues egalitarianism. The latter is my view. The essay criticizes the main arguments in defense of this principle of equality and offers an explanation why so many mistakenly believe that distributional inequalities are bad.
Changing Dynamics of Political Party Communication: The Case of New Media in Bangladesh
Authors: Sakib Nurul Huda , Shishir Foysal Jaman , Rahman Mohammad Sajedur 
Published: October 2024

Abstract
Political parties are spending time, effort, and money on new media campaigns targeting users of Facebook, Twitter, and other social media platforms. This trend has been observed in the context of elections in Bangladesh where, over the past couple of years, one of the most critical tools for political campaigns in national and local elections has been social media (predominantly Facebook). To explore this communication trend, this study aims to investigate political campaigns on social media during Bangladesh’s 11th national election held in December 2018. Even though the election result was controversial, electoral campaigns by the major political parties recorded significant use of social media to attract citizens, including the 20 million new voters. This study presents evidence from content analysis of the official Facebook pages of two major political alliances (led by the Bangladesh Awami League and the Bangladesh Nationalist Party), as well as from individual social media campaigns by candidates from these two parties, as it investigates the changing dynamics of political party communication in Bangladesh. The study also analyzes similarities and dissimilarities of new media campaigns by the different major political parties and the impacts of new media use on the political system and democratic profile of Bangladesh.
From a ‘Peaceful and Prosperous China’ to ‘the China Virus’: Examining the Framing of China Through American Political Rhetoric
Authors: Maher Finnian 
Published: October 2024

Abstract
The period comprising the past thirty-two years since the collapse of the Soviet Union has seen a range of approaches taken by the United States in handling its relationship with China. Launched in November 2011, the ‘Pivot to Asia’ policy approach entailed new levels of engagement with ‘a peaceful and prosperous China’, but on the most challenging issues this approach also brought increasing confrontation. The West (in this case the United States) has a history of utilising Orientalist-style, ‘us vs them’ dichotomies to manipulate unequal relations of power with the East (known as the ‘Orient’) throughout history (originally with middle-eastern nations). By using tenets from Edward Said’s Orientalism and critical discourse analysis adapted from Normal Fairclough’s 3-dimensional model, this article seeks to establish whether the foreign policy rhetoric of the United States has shifted to frame China through an Orientalist worldview since the Obama Administration’s “Pivot to Asia” strategy in late 2011. The article analyses 52 speeches from the Obama and Trump Administrations, finding evidence of pro-orientalist themes and language being adopted for both. Whilst utilised to a lower degree, these ‘us vs them’ dichotomies do exist under President Obama’s more accommodating and calmer linguistic-style, being intertwined with language designed to project an image of welcoming cooperation (albeit in a condescending, back-handed way). The use of orientalist themes is more prominently provable under President Trump, with almost all major speeches pertaining to China containing high usage of orientalist tropes in a more openly xenophobic, racist fashion.
Digital Afterlife and the Future of Collective Memory
Authors: Meitzler Matthias , Heesen Jessica , Hennig Martin , Quinn Regina Ammicht 
Published: October 2024

Abstract
Digital technology increasingly addresses people dealing with dying, death and grief. The range of options now extends to ai-based forms of “digital afterlife”, in which the deceased are represented digitally in the form of a chatbot or avatar. Based on large amounts of personal data, they can simulate the person’s communicative behavior, including their visual appearance, thus enabling him or her to interact with users. The applications of the so-called Digital Afterlife Industry not only offer new possibilities in the fields of grief culture, the education sector, and the entertainment industry, but also raise ethical, legal and security-related questions that have so far received little attention. At the intersection of technological innovation (especially artificial intelligence), cultures of mourning and collective memory, this article discusses the (potential) social effects of a digital afterlife and its implication in terms of memory. We will particularly address the fact that more and more people in their everyday life are able to use a digital public representation, which continues after their death and with which users can interact.
Sinonasal Outcomes after Endoscopic Pituitary Surgery in Patients With Cushing’s Disease
Authors: Kolia Nadeem R. , Fleseriu Cara M. , Thavaraputta Subhanudh , Fazeli Pouneh K. , Gardner Paul A. , Snyderman Carl H. , Wang Eric W. 
Published: October 2024

Purpose: The endoscopic endonasal approach (EEA) has become the preferred treatment for pituitary tumors, with minimal sinonasal morbidity. However, patients with Cushing’s disease (CD) may represent a subgroup with prolonged impairment of sinonasal quality of life (QOL). Methods: We retrospectively identified patients with CD who underwent EEA at our institution. Control patients with non-functional tumors were matched by age, gender, and extent of EEA. The primary outcome was post-operative 22-item Sino-Nasal Outcome Test (SNOT-22) scores. Results: Ten patients with CD met the selection criteria and 20 controls were selected for comparison. Nine of the CD patients achieved persistent endocrinologic remission post-operatively. Comparing the CD and control groups, there was no difference in post-operative SNOT-22 score at 1 or 3 months. At 6 months, SNOT-22 scores were significantly worse in the CD group (27.4 ± 21.6 vs. 2.8 ± 2.3, P = .039). SNOT-22 scores improved to normal from 1 to 6 months in the control cohort ( P = .007), but not in the Cushing’s group ( P = .726). Morbidity was present across all SNOT-22 domains, but was highest in the sleep domain ( P = .023). Only morbidity in the facial domain improved over time ( P = .032). Conclusions: Patients with CD have significantly prolonged postoperative sinonasal QOL impairment following EEA compared to patients with non-functioning tumors, who normalize within 6 months. In CD patients, only morbidity in the facial domain, likely related to post-operative pain and nasal packing, improved over time, while the sleep domain was the most affected.
Effect of Group Motivational Enhancement Therapy in Patients with Opioid Dependence (on Maintenance Treatment): Study Protocol of a Randomized Controlled Trial
Authors: Mishra Sudha , Kar Sujita Kumar , Singh Amit , Nischal Anil , Agarwal Vivek 
Published: October 2024

Background: Relapse and treatment dropout are key challenges in opioid use disorder that need effective intervention strategies. Motivation enhancement therapy may be effective in improving opioid use disorder treatment outcomes. Objective: To assess the effectiveness of group motivational enhancement therapy (GMET) in patients with opioid dependence. Methods: It is an open-label, two-arm, parallel-group, randomized controlled trial (RCT). Participants include patients with opioid dependence and on opioid maintenance treatment, aged between 18 and 60 years. The intervention consists of six GMET sessions, each lasting about 45 minutes. Assessments will be conducted at four time points—baseline, six weeks, four months, and six months—using the Kessler psychological distress scale (K10), Recovery and Relapse Prevention Inventory Diagnostic (RAPID), WHO Quality of Life-BREF, Harm Reduction Self-Efficacy Questionnaire and Stage of Change Readiness and Treatment Eagerness Scale for drugs (SOCRATES 8D). Conclusion: The customized GMET approach tailored to the specific needs of the local population is expected to enhance the effectiveness and feasibility of the intervention and its implementation.
Designing and Implementing the Psychiatrist-led Personalized Mentorship Programs: The Role and Impact of Live Consultation-driven Training Methods
Authors: Manjunatha Narayana , Shadakshari Darshan , Singhal Priyanka , Kumar Channaveerachari Naveen , Math Suresh Bada 
Published: October 2024

Background: Clinical training in traditional medical education often needs more translational value, especially for in-service MBBS doctors working in primary health centers (PHCs), who provide first-line treatment for psychiatric disorders. To address this gap, a psychiatrist-led personalized mentorship program incorporating three live consultation-driven training (CDT) methods was developed to integrate psychiatric care into PHCs. Methods: The authors designed and implemented a personalized mentorship program using three CDT methods tailored for in-service MBBS doctors. The CDT methods were applied through live consultations to facilitate real-time, real-life learning and integration of psychiatric care into primary health settings. Data from published articles and manuals on CDT methods were collected, focusing on their descriptions, effectiveness, principles, and advantages over traditional classroom training. Results: Data indicate the effectiveness of the CDT methods to translate to real-life skills (translational quotient). The personalized mentorship program showed promising results in enhancing the confidence and competence of MBBS doctors in managing psychiatric disorders in PHCs. The CDT methods were found to be superior to traditional classroom training in terms of practical applicability and real-time learning. Conclusion: The psychiatrist-led personalized mentorship program with CDT methods demonstrates the potential for significant improvements in the training of in-service MBBS doctors, facilitating the integration of psychiatric care into PHCs. These methods offer a practical and effective approach to bridging the gap in clinical training and can be replicated among medical students and residents across various medical and surgical specialties. Further research and longitudinal studies are recommended to validate these preliminary findings and explore the program’s broader applicability.
Self-care towards the end of life: A systematic review and narrative synthesis on access, quality and cost
Authors: Gallagher Joshua , Antunes Bárbara , Sutton James , Kuhn Isla , Kelly Michael P , Duschinsky Robbie , Barclay Stephen 
Published: October 2024

Background: Policy and practice encourages patients to engage in self-care, with individual patient management and remote monitoring of disease. Much is known of the moderate stage of chronic disease, without a clear understanding of how self-care applies towards the end of life. Aim: To review the current evidence on practices of self-care in life-limiting conditions and its impacts on healthcare utilisation, quality of life and associated costs. Design: We systematically searched 10 scientific databases (MEDLINE, CINAHL, Embase, PsycINFO, Cochrane Central, Cochrane Database of Systematic Reviews, Scopus, Sociological Abstracts, Social Work Abstracts and Health Management Information Consortium) from inception to October 2023 with citation and hand searching. A narrative synthesis was undertaken, with quality and relevance assessed using Gough’s Weight of Evidence framework. Titles and abstracts were independently screened by three researchers. Results: Findings from 33 studies revealed self-care as increasingly burdensome or unfeasible towards the end of life, with patients delaying use of professional care. Self-care became increasingly burdensome for patients, carers and professionals as illness progressed. Self-monitoring may exacerbate hospitalisations as patients delayed seeking professional help until crises arose. Findings regarding quality were inconclusive, with some evidence suggesting that self-care can decrease care costs. Conclusions: This review has shown that research on self-care is an evolving area of study, with a current focus on acute care and hospitalisations. Future research should seek to provide a more complete account of the relation between self-care and non-acute care use, and quality, with further efforts to study self-care costs incurred through self-funding.