bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-functioning autism patients share similar but more severe impairments in verbal theory of mind than schizophrenia patients
Authors: Tin L. N. W. , Lui S. S. Y. , Ho K. K. Y. , Hung K. S. Y. , Wang Y. , Yeung H. K. H. , Wong T. Y. , Lam S. M. , Chan R. C. K. , Cheung E. F. C. 
Published: September 2017

AbstractBackgroundEvidence suggests that autism and schizophrenia share similarities in genetic, neuropsychological and behavioural aspects. Although both disorders are associated with theory of mind (ToM) impairments, a few studies have directly compared ToM between autism patients and schizophrenia patients. This study aimed to investigate to what extent high-functioning autism patients and schizophrenia patients share and differ in ToM performance.MethodsThirty high-functioning autism patients, 30 schizophrenia patients and 30 healthy individuals were recruited. Participants were matched in age, gender and estimated intelligence quotient. The verbal-based Faux Pas Task and the visual-based Yoni Task were utilised to examine first- and higher-order, affective and cognitive ToM. The task/item difficulty of two paradigms was examined using mixed model analyses of variance (ANOVAs). Multiple ANOVAs and mixed model ANOVAs were used to examine group differences in ToM.ResultsThe Faux Pas Task was more difficult than the Yoni Task. High-functioning autism patients showed more severely impaired verbal-based ToM in the Faux Pas Task, but shared similar visual-based ToM impairments in the Yoni Task with schizophrenia patients.ConclusionsThe findings that individuals with high-functioning autism shared similar but more severe impairments in verbal ToM than individuals with schizophrenia support the autism–schizophrenia continuum. The finding that verbal-based but not visual-based ToM was more impaired in high-functioning autism patients than schizophrenia patients could be attributable to the varied task/item difficulty between the two paradigms.
ELECTRONIC DEVICES FOR COGNITIVE IMPAIRMENT SCREENING: A SYSTEMATIC LITERATURE REVIEW
Authors: García-Casal J. Antonio , Franco-Martín Manuel , Perea-Bartolomé M. Victoria , Toribio-Guzmán J. Miguel , García-Moja Carlos , Goñi-Imizcoz Miguel , Csipke Emese 
Published: September 2017

Objectives:The reduction in cognitive decline depends on timely diagnosis. The aim of this systematic review was to analyze the current available information and communication technologies-based instruments for cognitive decline early screening and detection in terms of usability, validity, and reliability.Methods:Electronic searches identified 1,785 articles of which thirty-four met the inclusion criteria and were grouped according to their main purpose into test batteries, measures of isolated tasks, behavioral measures, and diagnostic tools.Results:Thirty one instruments were analyzed. Fifty-two percent were personal computer based, 26 percent tablet, 13 percent laptop, and 1 was mobile phone based. The most common input method was touchscreen (48 percent). The instruments were validated with a total of 4,307 participants: 2,146 were healthy older adults (M = 73.59;SD= 5.12), 1,104 had dementia (M = 74.65;SD= 3.98) and 1,057 mild cognitive impairment (M = 74.84;SD= 4.46). Only 6 percent were administered at home, 19 percent reported outcomes about usability, and 22 percent about understandability. The methodological quality of the studies was good, the weakest methodological area being usability. Most of the instruments obtained acceptable values of specificity and sensitivity.Conclusions:It is necessary to create home delivered instruments and to include usability studies in their design. Involvement of people with cognitive decline in all phases of the development process is of great importance to obtain valuable and user-friendly products. It would be advisable for researchers to make an effort to provide cutoff points for their instruments.
MEDICAL DEVICE RECALLS IN CANADA FROM 2005 TO 2015
Authors: Gagliardi Anna R. , Takata Julie , Ducey Ariel , Lehoux Pascale , Ross Sue , Trbovich Patricia L. , Easty Anthony , Bell Chaim M. , Urbach David R. 
Published: September 2017

Objectives: Medical devices are ubiquitous in modern medical care. However, little is known about the epidemiology of medical devices in the healthcare marketplace, including the rate at which medical devices are subject to recalls or other advisories. We sought to study the epidemiology of medical devices in Canada, focusing on device recalls. In Canada, a recall may signify a variety of events, ranging from relatively minor field safety notifications, to removal of a product from the marketplace.Methods: We used data from Health Canada to study medical device recalls in Canada from 2005 to 2015. We analyzed the risks of medical device recalls according to the risk class of the device (I lowest; IV highest) and the hazard priority of the recall (Type I highest potential harm; Type III lowest potential harm).Results: During a 10-year period, there were 7,226 medical device recalls. Most recalls were for intermediate risk class (Class II, 40.1 percent; Class III, 38.7 percent) medical devices. Among recalled devices, 5.0 percent were judged to have a reasonable probability of serious adverse health consequences or death (Type I recall Hazard Priority classification). While the number of medical devices marketed in Canada is not known, over a similar 10-year period, 24,849 new Class II, II, and IV medical device licenses were issued by Health Canada.Conclusions: Several hundred medical device recalls occur in Canada each year. Further research is needed to characterize the nature of medical device recalls, and to explore how consumers use information about recalls.
Macrophage-released ADAMTS1 promotes muscle stem cell activation
Authors: Du Hongqing , Shih Chung-Hsuan , Wosczyna Michael N. , Mueller Alisa A. , Cho Joonseok , Aggarwal Abhishek , Rando Thomas A. , Feldman Brian J. 
Published: September 2017

AbstractCoordinated activation of muscle stem cells (known as satellite cells) is critical for postnatal muscle growth and regeneration. The muscle stem cell niche is central for regulating the activation state of satellite cells, but the specific extracellular signals that coordinate this regulation are poorly understood. Here we show that macrophages at sites of muscle injury induce activation of satellite cells via expression of Adamts1. Overexpression of Adamts1 in macrophages in vivo is sufficient to increase satellite cell activation and improve muscle regeneration in young mice. We demonstrate that NOTCH1 is a target of ADAMTS1 metalloproteinase activity, which reduces Notch signaling, leading to increased satellite cell activation. These results identify Adamts1 as a potent extracellular regulator of satellite cell activation and have significant implications for understanding the regulation of satellite cell activity and regeneration after muscle injury.
Effects of preanalytical frozen storage time and temperature on screening coagulation tests and factors VIII and IX activity
Authors: Zhao Ying , Feng Guofang , Zhang Jie , Gong Renjie , Cai Changming , Feng Limin 
Published: September 2017

AbstractPreanalytical quality control of blood samples is critical for tests of coagulation function and coagulation factor activity. Preanalytical storage time and temperature are the main variables. We investigated the effects of preanalytical frozen storage time and temperature on activated partial thromboplastin time (APTT), fibrinogen (Fbg), prothrombin time (PT)/international normalized ratio (INR), thrombin time (TT), factor VIII activity (FVIII:C), and factor IX activity (FIX:C) in frozen plasma. Samples (n = 144) were randomly and equally divided into four groups (storage at −80 °C or −20 °C) and analysed by CS5100 or CA7000 coagulation analysers. Baseline values and results after storage for 15 days, 1 month, 3 months, 6 months, and 1 year were measured after thawing. Mean percent changes and scatter plots were used to determine clinically relevant differences. The stabilities of coagulation tests and coagulation factor activities measured by the CS5100 system were consistent with those measured by the CA7000 system. At −80 °C, assessment samples of PT/INR, Fbg, and TT can be safely stored for 1 year, APTT for 6 months, and FVIII:C and FIX:C for 1 month. At −20 °C, samples of Fbg and TT can be stored for 1 year, PT/INR and FIX:C for 1 month, and APTT and FVIII:C for 15 days.
White Light-Emitting Diodes Based on Individual Polymerized Carbon Nanodots
Authors: Xie Zheng , Yin Zhengmao , Wu Yongzhong , Liu Chunyan , Hao Xiaopeng , Du Qingqing , Xu Xiangang 
Published: September 2017

AbstractA search for new phosphor materials that exhibit high light-emission, spectral purity, long-time stability and processability capture particular attention to modern solid-state lighting. Here, polymerizable silane pre-functionalized carbon dot (SiCD) fluids were dripped and co-polymerized or completely bulk polymerized to build color conversion and encapsulation coatings of commercially available GaN blue LEDs. Most parameters of SiCD-based white LEDs were similar to or even better than those of phosphor-based white LEDs, particularly the insensitivity to excitation wavelength and working current. Thus, SiCDs were superior to those phosphors in terms of broadband properties, high transparency (no light blocking and leaking), as well as arbitrary doping of its content as color conversion and encapsulation layers simultaneously, unique solubility, flexible chemical, optical and mechanical processability. Thus, designing new CD-based white LEDs, instead of inorganic rare earth phosphor-based LEDs, is possible for better performance solid state lighting devices.
Multiplexed Exchange-PAINT imaging reveals ligand-dependent EGFR and Met interactions in the plasma membrane
Authors: Werbin Jeffrey L. , Avendaño Maier S. , Becker Verena , Jungmann Ralf , Yin Peng , Danuser Gaudenz , Sorger Peter K. 
Published: September 2017

AbstractSignal transduction by receptor tyrosine kinases (RTKs) involves complex ligand- and time-dependent changes in conformation and modification state. High resolution structures are available for individual receptors dimers, but less is known about receptor clusters that form in plasma membranes composed of many different RTKs with the potential to interact. We report the use of multiplexed super-resolution imaging (Exchange-PAINT) followed by mean-shift clustering and random forest analysis to measure the precise distributions of five receptor tyrosine kinases (RTKs) from the ErbB, IGF-1R and Met families in breast cancer cells. We find that these receptors are intermixed nonhomogenously on the plasma membrane. Stimulation by EGF does not appear to induce a change in the density of EGFR in local clusters but instead results in formation of EGFR-Met and EGFR-ErbB3 associations; non-canonical EGFR-Met interactions are implicated in resistance to anti-cancer drugs but have not been previously detected in drug-naïve cells.
Nutrient quality of vertebrate dung as a diet for dung beetles
Authors: Frank Kevin , Brückner Adrian , Hilpert Andrea , Heethoff Michael , Blüthgen Nico 
Published: September 2017

AbstractAt the basis of a trophic web, coprophagous animals like dung beetles (Scarabaeoidea) utilize resources that may have advantages (easy gain and handling) as well as drawbacks (formerly processed food). Several studies have characterized the nutrients, e.g. C/N ratios and organic matter content, for specific types of dung. However, a comparative approach across dung types and feeding guilds of dung producers, and relationships between dung nutrients and preferences by coprophages, have been missing. Hence, we analyzed water content, C/N ratio, amino acid, neutral lipid fatty acid, free fatty acid and sterol composition and concentrations in dung from 23 vertebrates, including carnivore, omnivore and herbivore species. Our analyses revealed significant differences among the three vertebrate feeding guilds for most nutritional parameters. Although formerly processed, dung grants sufficient amounts of essential nutrients for insects. We tested whether nutrients can explain the dung beetles’ preferences in a field experiment, using 12 representative dung types in baits that were installed in 27 forests and 27 grasslands. Although consistent preferences for specific dung types were pronounced, the nutritional composition did not predict the variation in attractiveness of these dung diets, suggesting a primary role of dung volatiles irrespective of food quality.
Spatio-temporal analysis of small-area intestinal parasites infections in Ghana
Authors: Osei F. B. , Stein A. 
Published: September 2017

AbstractIntestinal parasites infection is a major public health burden in low and middle-income countries. In Ghana, it is amongst the top five morbidities. In order to optimize scarce resources, reliable information on its geographical distribution is needed to guide periodic mass drug administration to populations of high risk. We analyzed district level morbidities of intestinal parasites between 2010 and 2014 using exploratory spatial analysis and geostatistics. We found a significantly positive Moran’s Index of spatial autocorrelation for each year, suggesting that adjoining districts have similar risk levels. Using local Moran’s Index, we found high-high clusters extending towards the Guinea and Sudan Savannah ecological zones, whereas low-low clusters extended within the semi-deciduous forest and transitional ecological zones. Variograms indicated that local and regional scale risk factors modulate the variation of intestinal parasites. Poisson kriging maps showed smoothed spatially varied distribution of intestinal parasites risk. These emphasize the need for a follow-up investigation into the exact determining factors modulating the observed patterns. The findings also underscored the potential of exploratory spatial analysis and geostatistics as tools for visualizing the spatial distribution of small area intestinal worms infections.
Radiation forces of beams generated by Gaussian mirror resonator on a Rayleigh dielectric sphere
Authors: Tang Bin , Chen Kai , Bian Lirong , Zhou Xin , Huang Li , Jin Yi 
Published: September 2017

AbstractOptical trapping and manipulating of micron-sized particles have attracted enormous interests due to the potential applications in biotechnology and nanoscience. In this work, we investigate numerically and theoretically the radiation forces acting on a Rayleigh dielectric particle produced by beams generated by Gaussian mirror resonator (GMR) in the Rayleigh scattering regime. The results show that the focused beams generated by GMR can be used to trap and manipulate the particles with both high and low index of refractive near the focus point. The influences of optical parameters of the beams generated by GMR on the radiation forces are analyzed in detail. Furthermore, the conditions for trapping stability are also discussed in this paper.
Stability and optical properties of plutonium monoxide from first-principle calculation
Authors: Qiu Ruizhi , Zhang Yongbin , Ao Bingyun 
Published: September 2017

AbstractThe resolution of questions about the existence of condensed plutonium monoxide (PuO) has long been hindered by lack of thermochemical data. Here we perform first-principles calculation to investigate the reaction Pu2O3 + Pu → 3 PuO and find that PuO is thermodynamically unstable under ambient pressure. We also find that pressure could stabilize PuO by strengthening the hybridization between Pu-5f/6dand O-2pstates. Moreover, the dynamical stability of NaCl-type PuO is verified by the phonon calculation. Optical properties such as reflectivity are also predicted for the detection of metallic PuO.
Adjuvant IL-7 potentiates adoptive T cell therapy by amplifying and sustaining polyfunctional antitumor CD4+ T cells
Authors: Ding Zhi-Chun , Habtetsion Tsadik , Cao Yang , Li Tao , Liu Chufeng , Kuczma Michal , Chen Tingting , Hao Zhonglin , Bryan Locke , Munn David H. , Zhou Gang 
Published: September 2017

AbstractIncreased availability of homeostatic cytokines is considered a major mechanism by which lymphodepletion enhances the efficacy of adoptive T cell therapy (ACT). IL-7 is one such cytokine capable of augmenting the function of tumor-reactive CD8+ T cells. However, whether host-derived IL-7 plays a role in driving the proper function of CD4+ T cells in an ACT setting remains unclear. Here we report that lymphodepleting chemotherapy by cyclophosphamide (CTX) does not lead to increased availability of the endogenous IL-7 in mice. Despite of a paucity of IL-7 in the immune milieu, CTX preconditioning allowed adoptively transferred naïve tumor-specific CD4+ T cells to undergo effector differentiation and regain IL-7Rα expression, giving rise to IL-7-responsive polyfunctional CD4+ effector cells. Correspondingly, supplementation of exogenous recombinant IL-7 markedly amplified and sustained polyfunctional CD4+ effector cells, resulting in improved therapeutic outcome in a mouse lymphoma model. We further demonstrated that the immune-enhancing effects of IL-7 were also applicable to donor CD4+ T cells pre-activated under Th1 polarizing condition. These findings suggest caution in relying on the endogenous IL-7 to enhance donor T cell expansion and persistence after lymphodepleting chemotherapy, and highlight the usefulness of recombinant IL-7 as an adjuvant for adoptive immunotherapy.
Effects of transthoracic device closure on ventricular septal defects and reasons for conversion to open-heart surgery: A meta-analysis
Authors: Zhou Yang , Liu Ling-Xi , Zhao Fei , Tang Shi-Hai , Peng Hua-Li , Jiang Yun-Han 
Published: September 2017

AbstractTransthoracic device closure (TTDC) is thought to be a promising technology for the repair of ventricular septal defects (VSDs). However, there is considerable controversy regarding the efficacy and safety of TTDC. The present study aimed to compare the benefits and safety of TTDC with those of conventional open-heart surgery (COHS) and analyze the associated factors causing complications, conversion to COHS and reoperation. Electronic database searches were conducted in PubMed, EMBASE, Cochrane Library, Clinicaltrials.gov and several Chinese databases. A total of 5 randomized controlled trials (RCTs), 7 cohort studies, 13 case-control studies, 129 case series and 13 case reports were included. Compared to COHS, TTDC exhibited superior efficacy with a significantly lower risk of post-operative arrhythmia; however, no significant differences in other outcomes were identified. Meta-regression analysis showed that perimembranous VSDs (pmVSDs), a smaller VSD, a smaller occluder, and a median or subxiphoid approach lowered the relative risk of several post-operative complications, conversion to COHS and reoperation. The current evidence indicates that TTDC is associated with a lower risk of post-operative arrhythmia and is not associated with an increased risk of complications. PmVSDs, a smaller VSD and occluder, and a median or subxiphoid approach correlate with better outcomes when using TTDC.
The cosmological analysis of X-ray cluster surveys
Authors: Pierre M. , Valotti A. , Faccioli L. , Clerc N. , Gastaud R. , Koulouridis E. , Pacaud F. 
Published: September 2017

Context. Despite compelling theoretical arguments, the use of clusters as cosmological probes is, in practice, frequently questioned because of the many uncertainties surrounding cluster-mass estimates.
Aims. Our aim is to develop a fully self-consistent cosmological approach of X-ray cluster surveys, exclusively based on observable quantities rather than masses. This procedure is justified given the possibility to directly derive the cluster properties via ab initio modelling, either analytically or by using hydrodynamical simulations. In this third paper, we evaluate the method on cluster toy-catalogues.
Methods. We model the population of detected clusters in the count-rate – hardness-ratio – angular size – redshift space and compare the corresponding four-dimensional diagram with theoretical predictions. The best cosmology+physics parameter configuration is determined using a simple minimisation procedure; errors on the parameters are estimated by averaging the results from ten independent survey realisations. The method allows a simultaneous fit of the cosmological parameters of the cluster evolutionary physics and of the selection effects.
Results. When using information from the X-ray survey alone plus redshifts, this approach is shown to be as accurate as the modelling of the mass function for the cosmological parameters and to perform better for the cluster physics, for a similar level of assumptions on the scaling relations. It enables the identification of degenerate combinations of parameter values.
Conclusions. Given the considerably shorter computer times involved for running the minimisation procedure in the observed parameter space, this method appears to clearly outperform traditional mass-based approaches when X-ray survey data alone are available.
Contemporary Management of Pulmonary Arteriovenous Malformations
Authors: Rauh Nicholas , Gurley John , Saha Sibu 
Published: September 2017

AbstractPulmonary arteriovenous malformations (PAVMs) are atypical vascular structures involving a direct connection between the pulmonary arterial and venous circulations. While PAVMs are a relatively uncommon disorder, unmanaged cases are at risk for the development of serious complications including embolization and infection. Since their first description in 1897, PAVMs have been identified and treated in a variety of ways. Advancements in diagnostic methods and operative techniques have allowed for more effective treatment of the disease. Most recently, the use of vascular plug transcatheter embolization has been described as an effective therapeutic procedure in the management of PAVMs. In this report, we present our experience with nine cases of PAVMs treated at the University of Kentucky, including special consideration of an exemplary case that illustrates the typical course of treatment for the disease.
Metonymy in human interaction
Authors: Jódar-Sánchez José Antonio 
Published: September 2017

AbstractHuman communication is based on mutual interaction between participants. Much of this communication is linguistic in nature. Language is structured by grammar and grammar is inherently metonymic (Langacker 2009). Thus, language and interaction must be metonymic. In this article, I explore the metonymic basis of human interaction in both its linguistic and non-linguistic aspects. First, I make a distinction between linguistic and cultural metonymy. Both have a conceptual basis. The former, extensively studied from the view of cognitive linguistics, has a linguistic source. The latter, found in fields as diverse as art, theater, and film, does not necessarily have a linguistic source. The broader concept of cultural metonymy seems to structure human interaction. Second, I delineate distinguishing factors between the two types of metonymies. Those are the nature of the source and the (mis)match in the intentionality of producer and perceiver. Third, I make an overview and provide real examples of what aspects of human interaction are metonymic. Its elements, including the content of the message, the identity, proxemics, and kinesics of the participants, and the context of the interaction, can be metonymic. Its processes, namely those of language production and reception, are as well inherently metonymic. Overall, I show that metonymy, understood as relatedness or association, pervades human interaction and plays an important role in its success.