bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers
Authors: Yuan Jian-Min , Stepanov Irina , Murphy Sharon E. , Wang Renwei , Allen Sharon , Jensen Joni , Strayer Lori , Adams-Haduch Jennifer , Upadhyaya Pramod , Le Chap , Kurzer Mindy S. , Nelson Heather H. , Yu Mimi C. , Hatsukami Dorothy , Hecht Stephen S. 
Published: March 2016

Abstract
2-Phenethyl isothiocyanate (PEITC), a natural product found as a conjugate in watercress and other cruciferous vegetables, is an inhibitor of the metabolic activation and lung carcinogenicity of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in F344 rats and A/J mice. We carried out a clinical trial to determine whether PEITC also inhibits the metabolic activation of NNK in smokers. Cigarette smokers were recruited and asked to smoke cigarettes containing deuterium-labeled [pyridine-D4]NNK for an acclimation period of at least 1 week. Then subjects were randomly assigned to one of two arms: PEITC followed by placebo, or placebo followed by PEITC. During the 1-week treatment period, each subject took PEITC (10 mg in 1 mL of olive oil, 4 times per day). There was a 1-week washout period between the PEITC and placebo periods. The NNK metabolic activation ratio [pyridine-D4]hydroxy acid/total [pyridine-D4]NNAL was measured in urine samples to test the hypothesis that PEITC treatment modified NNK metabolism. Eighty-two smokers completed the study and were included in the analysis. Overall, the NNK metabolic activation ratio was reduced by 7.7% with PEITC treatment (P = 0.023). The results of this trial, while modest in effect size, provide a basis for further investigation of PEITC as an inhibitor of lung carcinogenesis by NNK in smokers. Cancer Prev Res; 9(5); 396–405. ©2016 AACR.
Conditional Deletion of
Hsd11b2
in the Brain Causes Salt Appetite and Hypertension
Authors: Evans Louise C. , Ivy Jessica R. , Wyrwoll Caitlin , McNairn Julie A. , Menzies Robert I. , Christensen Thorbjørn H. , Al-Dujaili Emad A.S. , Kenyon Christopher J. , Mullins John J. , Seckl Jonathan R. , Holmes Megan C. , Bailey Matthew A. 
Published: March 2016

Background—

The hypertensive syndrome of Apparent Mineralocorticoid Excess is caused by loss-of-function mutations in the gene encoding 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2), allowing inappropriate activation of the mineralocorticoid receptor by endogenous glucocorticoid. Hypertension is attributed to sodium retention in the distal nephron, but 11βHSD2 is also expressed in the brain. However, the central contribution to Apparent Mineralocorticoid Excess and other hypertensive states is often overlooked and is unresolved. We therefore used a Cre-Lox strategy to generate 11βHSD2 brain-specific knockout (
Hsd11b2
.BKO) mice, measuring blood pressure and salt appetite in adults.

Methods and Results—

Basal blood pressure, electrolytes, and circulating corticosteroids were unaffected in
Hsd11b2
.BKO mice. When offered saline to drink,
Hsd11b2
.BKO mice consumed 3 times more sodium than controls and became hypertensive. Salt appetite was inhibited by spironolactone. Control mice fed the same daily sodium intake remained normotensive, showing the intrinsic salt resistance of the background strain. Dexamethasone suppressed endogenous glucocorticoid and abolished the salt-induced blood pressure differential between genotypes. Salt sensitivity in
Hsd11b2
.BKO mice was not caused by impaired renal sodium excretion or volume expansion; pressor responses to phenylephrine were enhanced and baroreflexes impaired in these animals.

Conclusions—
Reduced 11βHSD2 activity in the brain does not intrinsically cause hypertension, but it promotes a hunger for salt and a transition from salt resistance to salt sensitivity. Our data suggest that 11βHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor–dependent pathway. Therefore, central mineralocorticoid receptor antagonism could increase compliance to low-sodium regimens and help blood pressure management in cardiovascular disease.
Standardization of Offshore Surface Wind Speeds
Authors: He Y. C. , Chan P. W. , Li Q. S. 
Published: March 2016

AbstractWind measurement offers an essential data source for a wide range of practices in the fields of meteorology and wind engineering. However, records of surface winds are usually influenced by terrain/topographic effects, and direct usage of raw data may bring in nonignorable errors for follow-up applications. A data-driven standardization scheme was recently proposed by the authors to convert the surface wind measurements over rugged terrain into their potential values corresponding to reference conditions, that is, for neutral winds at a height of 10 m above open flat terrain (z0 = 0.03 m). As a complementary part of the preceding work, this study focuses on the standardization of surface wind speeds with marine exposures. The effect of wind strength on the roughness of the sea surface is further taken into account, with emphasis on the difference between deep-ocean and shallow-water cases. As an application example, wind measurements at a buoy site near the coastal line (water depth is 14 m) are adjusted to their potential values, which are then compared with those at a nearby station. The good agreement between the two sets of results demonstrates the accuracy and effectiveness of the standardization method. It is also found that the behavior of roughness length scale over shallow water may differ noticeably from that over deep ocean, especially under strong wind conditions, and an inappropriate usage of marine roughness predictors may result in significant estimation errors.
Spatial and Temporal Characteristics of Summer Precipitation over Central Europe in a Suite of High-Resolution Climate Models
Authors: Lind Petter , Lindstedt David , Kjellström Erik , Jones Colin 
Published: March 2016

AbstractHigh-impact, locally intense rainfall episodes represent a major socioeconomic problem for societies worldwide, and at the same time these events are notoriously difficult to simulate properly in climate models. Here, the authors investigate how horizontal resolution and model formulation influence this issue by applying the HIRLAM–ALADIN Regional Mesoscale Operational NWP in Europe (HARMONIE) Climate (HCLIM) regional model with three different setups: two using convection parameterization at 15- and 6.25-km horizontal resolution (the latter within the “gray zone” scale), with lateral boundary conditions provided by ERA-Interim and integrated over a pan-European domain, and one with explicit convection at 2-km resolution (HCLIM2) over the Alpine region driven by the 15-km model. Seven summer seasons were sampled and validated against two high-resolution observational datasets. All HCLIM versions underestimate the number of dry days and hours by 20%–40% and overestimate precipitation over the Alpine ridge. Also, only modest added value was found for gray-zone resolution. However, the single most important outcome is the substantial added value in HCLIM2 compared to the coarser model versions at subdaily time scales. It better captures the local-to-regional spatial patterns of precipitation reflecting a more realistic representation of the local and mesoscale dynamics. Further, the duration and spatial frequency of precipitation events, as well as extremes, are closer to observations. These characteristics are key ingredients in heavy rainfall events and associated flash floods, and the outstanding results using HCLIM in a convection-permitting setting are convincing and encourage further use of the model to study changes in such events in changing climates.
Suppression of Atlantic Meridional Overturning Circulation Variability at Increased CO2
Authors: MacMartin Douglas G. , Zanna Laure , Tziperman Eli 
Published: March 2016

AbstractMultidecadal variability in the Atlantic meridional overturning circulation (AMOC) is shown to differ significantly between the 4 × CO2 and preindustrial control simulations of the GFDL Earth System Model, version 2M (ESM2M) general circulation model (GCM). In the preindustrial simulation, this model has a peak in the power spectrum of both AMOC and northward heat transport at latitudes between 26° and 50°N. In the 4 × CO2 simulation, the only significant spectral peak is near 60°N. Understanding these differences is important for understanding the effect of future climate change on climate variability, as well as for providing insight into the physics underlying AMOC variability. Transfer function analysis demonstrates that the shift is predominantly due to a shift in the internal ocean dynamics rather than a change in stochastic atmospheric forcing. Specifically, the reduction in variance from 26° to 45°N is due to an increased stratification east of Newfoundland that results from the shallower and weaker mean overturning. The reduced AMOC variance that accompanies the reduced mean value of the AMOC at 4 × CO2 differs from predictions of simple box models that predict a weaker circulation to be closer to a stability bifurcation point and, therefore, be accompanied by amplified variability. The high-latitude variability in the 4 × CO2 simulation is related to the advection of anomalies by the subpolar gyre, distinct from the variability mechanism in the control simulation at lower latitudes. The 4 × CO2 variability has only a small effect on midlatitude meridional heat transport, but does significantly affect sea ice in the northern North Atlantic.
Cloud–Radiation Feedback as a Leading Source of Uncertainty in the Tropical Pacific SST Warming Pattern in CMIP5 Models
Authors: Ying Jun , Huang Ping 
Published: March 2016

Abstract
The role of the intermodel spread of cloud–radiation feedback in the uncertainty in the tropical Pacific SST warming (TPSW) pattern under global warming is investigated based on the historical and RCP8.5 runs from 32 models participating in CMIP5. The large intermodel discrepancies in cloud–radiation feedback contribute 24% of the intermodel uncertainty in the TPSW pattern over the central Pacific. The mechanism by which the cloud–radiation feedback influences the TPSW pattern is revealed based on an analysis of the surface heat budget. A relatively weak negative cloud–radiation feedback over the central Pacific cannot suppress the surface warming as greatly as in the multimodel ensemble and thus induces a warm SST deviation over the central Pacific, producing a low-level convergence that suppresses (enhances) the evaporative cooling and zonal cold advection in the western (eastern) Pacific. With these processes, the original positive SST deviation over the central Pacific will move westward to the western and central Pacific, with a negative SST deviation in the eastern Pacific. Compared with the observed cloud–radiation feedback from six sets of reanalysis and satellite-observed data, the negative cloud–radiation feedback in the models is underestimated in general. It implies that the TPSW pattern should be closer to an El Niño–like pattern based on the concept of observational constraint. However, the observed cloud–radiation feedback from the various datasets also demonstrates large discrepancies in magnitude. Therefore, the authors suggest that more effort should be made to improve the precision of shortwave radiation observations and the description of cloud–radiation feedback in models for a more reliable projection of the TPSW pattern in future.
Explicit Representation of Spatial Subgrid-Scale Heterogeneity in an ESM
Authors: de Vrese Philipp , Hagemann Stefan 
Published: March 2016

Abstract
In present-day Earth system models, the coupling of land surface and atmosphere is based on simplistic assumptions. Often the heterogeneous land surface is represented by a set of effective parameters valid for an entire model grid box. Other models assume that the surface fluxes become horizontally homogeneous at the lowest atmospheric model level. For heterogeneity above a certain horizontal length scale this is not the case, resulting in spatial subgrid-scale variability in the fluxes and in the state of the atmosphere. The Max Planck Institute for Meteorology’s Earth System Model is used with three different coupling schemes to assess the importance of the representation of spatial heterogeneity at the land surface as well as within the atmosphere. Simulations show that the land surface–atmosphere coupling distinctly influences the simulated near-surface processes with respect to different land-cover types. The representation of heterogeneity also has a distinct impact on the simulated gridbox mean state and fluxes in a large fraction of land surface.
Global Observations of Open-Ocean Mode-1 M2 Internal Tides
Authors: Zhao Zhongxiang , Alford Matthew H. , Girton James B. , Rainville Luc , Simmons Harper L. 
Published: March 2016

AbstractA global map of open-ocean mode-1 M2 internal tides is constructed using sea surface height (SSH) measurements from multiple satellite altimeters during 1992–2012, representing a 20-yr coherent internal tide field. A two-dimensional plane wave fit method is employed to 1) suppress mesoscale contamination by extracting internal tides with both spatial and temporal coherence and 2) separately resolve multiple internal tidal waves. Global maps of amplitude, phase, energy, and flux of mode-1 M2 internal tides are presented. The M2 internal tides are mainly generated over topographic features, including continental slopes, midocean ridges, and seamounts. Internal tidal beams of 100–300 km width are observed to propagate hundreds to thousands of kilometers. Multiwave interference of some degree is widespread because of the M2 internal tide’s numerous generation sites and long-range propagation. The M2 internal tide propagates across the critical latitudes for parametric subharmonic instability (28.8°S/N) with little energy loss, consistent with the 2006 Internal Waves across the Pacific (IWAP) field measurements. In the eastern Pacific Ocean, the M2 internal tide loses significant energy in propagating across the equator; in contrast, little energy loss is observed in the equatorial zones of the Atlantic, Indian, and western Pacific Oceans. Global integration of the satellite observations yields a total energy of 36 PJ (1 PJ = 1015 J) for all the coherent mode-1 M2 internal tides. Finally, satellite observed M2 internal tides compare favorably with field mooring measurements and a global eddy-resolving numerical model.
A healthier workplace? Implementation of fruit boxes in the workplace
Authors: Pescud Melanie , Waterworth Pippa , Shilton Trevor , Teal Renee , Slevin Terry , Ledger Melissa , Lester Leanne , Rosenberg Michael 
Published: March 2016

Objective: The purpose of this study was to investigate whether making fruit boxes available in the workplace is a successful health promotion strategy. Design: A quasi-experimental study involving three conditions – free fruit, 50c per piece of fruit and $1 per piece of fruit – to investigate the effect of a contribution scheme on employees’ fruit purchase/consumption behaviours and willingness to contribute when in the paid conditions. Setting: Perth, Western Australia. Methods: In total, 36 workplaces participated and were randomly assigned to one of the three conditions. The results were analysed using generalised linear modelling. A qualitative follow-up was conducted with workplace representatives 6 weeks after the completion of the trial to investigate how many workplaces implemented the provision of fruit boxes after the trial and the factors influencing the decision to implement fruit boxes. Results: A significant difference in average fruit purchasing/consumption per person was found with respect to condition ( p < .001), with businesses in the free condition purchasing/consuming a significantly greater amount of fruit than businesses in the 50c contribution condition or $1 contribution condition. Following the trial, 13 workplaces continued providing their own fruit box, of which 7 were initially in the free condition. Qualitative findings revealed that management support, a receptive culture and sufficient resources were key to the implementation of fruit boxes. Conclusion: Having a fruit box may be a feasible health promotion strategy, and the financial burden of this strategy could be alleviated by asking employees to contribute to the cost of fruit.
Pilates exercise training vs. physical therapy for improving walking and balance in people with multiple sclerosis: a randomized controlled trial
Authors: Kalron Alon , Rosenblum Uri , Frid Lior , Achiron Anat 
Published: March 2016

Objective: Evaluate the effects of a Pilates exercise programme on walking and balance in people with multiple sclerosis and compare this exercise approach to conventional physical therapy sessions. Design: Randomized controlled trial. Setting: Multiple Sclerosis Center, Sheba Medical Center, Tel-Hashomer, Israel. Subjects: Forty-five people with multiple sclerosis, 29 females, mean age (SD) was 43.2 (11.6) years; mean Expanded Disability Status Scale (S.D) was 4.3 (1.3). Interventions: Participants received 12 weekly training sessions of either Pilates ( n=22) or standardized physical therapy ( n=23) in an outpatient basis. Main measures: Spatio-temporal parameters of walking and posturography parameters during static stance. Functional tests included the Time Up and Go Test, 2 and 6-minute walk test, Functional Reach Test, Berg Balance Scale and the Four Square Step Test. In addition, the following self-report forms included the Multiple Sclerosis Walking Scale and Modified Fatigue Impact Scale. Results: At the termination, both groups had significantly increased their walking speed ( P=0.021) and mean step length ( P=0.023). According to the 2-minute and 6-minute walking tests, both groups at the end of the intervention program had increased their walking speed. Mean (SD) increase in the Pilates and physical therapy groups were 39.1 (78.3) and 25.3 (67.2) meters, respectively. There was no effect of group X time in all instrumented and clinical balance and gait measures. Conclusions: Pilates is a possible treatment option for people with multiple sclerosis in order to improve their walking and balance capabilities. However, this approach does not have any significant advantage over standardized physical therapy.
Use of a knowledge-attitude-behaviour education programme for Chinese adults undergoing maintenance haemodialysis: Randomized controlled trial
Authors: Liu Li , Liu Yue-Ping , Wang Jing , An Li-Wei , Jiao Jian-Mei 
Published: March 2016

Objective To investigate the effects of a knowledge-attitude-behaviour health education model on acquisition of disease-related knowledge and self-management behaviour by patients undergoing maintenance haemodialysis. Methods Patients recently prescribed MHD were randomly assigned to a control group or an intervention group. Control group patients were treated with usual care and general education models. A specialist knowledge-attitude-behaviour health education model was applied to patients in the intervention group. Results Eighty-six patients were included ( n = 43 per group). Before intervention, there were no significant between-group differences in disease knowledge and self-management behaviour. After 6 months’ intervention, a significant between-group difference in acquisition of disease knowledge was observed. Self-management behaviour scores (control of body mass, reasonable diet, correct drug intake, physical activity, correct fistula care, disease condition monitoring, psychological and social behaviours) for the intervention group were also higher than those for the control group. Conclusion These preliminary findings suggest that the knowledge-attitude-behaviour model appears to be a valuable tool for the health education of MHD patients.
A human trigeminovascular biomarker for antimigraine drugs: A randomised, double-blind, placebo-controlled, crossover trial with sumatriptan
Authors: Ibrahimi K , Danser AHJ , Terwindt GM , van den Meiracker AH , MaassenVanDenBrink A 
Published: March 2016

Current antimigraine drugs are believed, besides their direct vasoconstrictive effect, to inhibit calcitonin gene-related peptide (CGRP) release from trigeminal nerve endings during migraine. Objective The objective of this report is to establish a biomarker for the CGRP-interfering effect of antimigraine drugs. Methods We quantified the effect of sumatriptan on the trigeminal nerve-mediated rise in forehead dermal blood flow (DBF), induced by capsaicin application (0.6 mg/ml) and electrical stimulation (0.2–1.0 mA), in a randomised, double-blind, placebo-controlled, crossover study in healthy male ( n = 11, age ± SD: 29 ± 8 years) and female ( n = 11, 32 ± 7 years) individuals. Results DBF responses to capsaicin were attenuated by sumatriptan (ΔDBF, mean ± SEM: 82 ± 18 AU, p = 0.0002), but not by placebo (ΔDBF: 21 ± 12 AU, p = 0.1026). Conclusion We demonstrated that sumatriptan inhibits increases in DBF, induced by the release of, most likely, CGRP. Thus, our model may be used as a biomarker to establish the trigeminovascular effects of (potential) antimigraine drugs, such as CGRP receptor antagonists or antibodies directed against CGRP or its receptor.
Minimalist Running Shoes and Injury Risk Among United States Army Soldiers
Authors: Grier Tyson , Canham-Chervak Michelle , Bushman Timothy , Anderson Morgan , North William , Jones Bruce H. 
Published: March 2016

Background: Minimalist running shoes (MRS) are lightweight, are extremely flexible, and have little to no cushioning. It has been thought that MRS will enhance running performance and decrease injury risk. Purpose: To compare physical characteristics, fitness performance, and injury risks associated with soldiers wearing MRS and those wearing traditional running shoes (TRS). Study Design: Case series; Level of evidence, 4. Methods: Participants were men in a United States Army brigade (N = 1332). Physical characteristics and Army Physical Fitness Test data were obtained by survey. Fitness performance testing was administered at the brigade, and the types of footwear worn were identified by visual inspection. Shoe types were categorized into 2 groups: TRS (stability, cushioning, and motion control) and MRS. Injuries from the previous 12 months were obtained from the Defense Medical Surveillance System. A t test was used to determine mean differences between personal characteristics, training, and fitness performance metrics by shoe type. Hazard ratios and 95% CIs were calculated to determine injury risk by shoe type, controlling for other risk factors. Results: A majority of soldiers wore cushioning shoes (57%), followed by stability shoes (24%), MRS (17%), and motion control shoes (2%). Soldiers wearing MRS were slightly younger than those wearing TRS ( P < .01); performed more push-ups, sit-ups, and pull-ups ( P < .01); and ran faster during the 2-mile run ( P = .01). When other risk factors were controlled, there was no difference in injury risk for running shoe type between soldiers wearing MRS compared with TRS. Conclusions: Soldiers who chose to wear MRS were younger and had higher physical performance scores compared with soldiers wearing TRS. When these differences are controlled, use of MRS does not appear to be associated with higher or lower injury risk in this population.