bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the efficacy of a generic plerixafor versus Mozobil as adjunct peripheral blood stem cell mobilization agents in multiple myeloma patients
Authors: Yuan Shan , Chang Shelley , Kim Hoim , Wang Shirong 
Published: October 2024

AbstractBackgroundPlerixafor is an adjunct peripheral blood stem cell (PBSC) mobilization agent with well‐demonstrated safety and efficacy. The routine use of the originator brand drug (Mozobil) has been limited by cost. This retrospective study was conducted to compare the mobilization efficacy of a lower‐cost generic plerixafor and Mozobil in multiple myeloma (MM) patients.Study Design and MethodsThe study included two near‐concurrent cohorts of MM patients mobilized with brand (n = 64) or generic (n = 61) plerixafor in addition to filgrastim. Collection and early engraftment outcomes were compared.ResultsThe two cohorts had comparable distributions of sex, age, and weight. Previous treatment histories and proportions of upfront versus just‐in‐time plerixafor use were similar. There was no significant difference in their median overall cumulative total yield (106 CD34+ cells/kg) (brand, 5.91; generic, 5.80; p = .51). However, the generic cohort had a significantly higher median yield after the first dose (4.79 vs. 3.78, p = .03), and consequently lower median numbers of plerixafor doses (p = .001) and collection days (p = .002). Only 31.1% of patients in the generic arm required more than one dose versus 59.4% of patients in the brand arm (p = .006).All transplanted patients in the brand and generic arms (90.6% and 85.2% respectively, p = .42) achieved engraftment. There was no significant difference in their median times to platelet and neutrophil engraftment, nor their transfusion requirements during the first 30 days post‐transplant.ConclusionThe generic plerixafor produced comparable cumulative collection yields and early engraftment outcomes as Mozobil, but fewer doses and collection days were needed to reach collection goal.
The pro‐competitive effects of indirect export exposures: Evidence from China
Authors: Li Jie , Lu Angdi 
Published: October 2024

AbstractUsing China's accession to WTO in 2001 as an episode for trade liberalisation, this paper empirically investigates whether export expansions affect firms' markup adjustments through local production networks. Following Helm (2020), we construct an indirect local export exposure measure to capture the degree to which firms in each prefecture‐industry cell are indirectly affected by export expansions of other local industries. To analyse the role played by local production networks, we further decompose indirect export shocks into upstream and downstream shocks. Combining this with markups estimated following De Loecker et al. (2016), our empirical results suggest that the average level of indirect export shocks would lead to a 0.363 decrease in markups. This magnitude accounts for 6.862% of overall markup changes during 2000–2007. In particular, the baseline results are driven by local indirect shocks from downstream industries. Further empirical analysis shows that reductions in firms' markups are induced by increased competition, which can be summarised as the “indirect pro‐competitive effects”. Further analysis at the prefecture‐industry level reveals that the impact mainly exists at the within‐firm margin, not at the between‐firm, or entry/exit margin.
Radiographic anatomy of the nasal conchal bullae and conchal sinuses in mature horses
Authors: Piñeros Diego Darley Velasquez , de Lima Aymara Eduarda , de Souza Anderson Fernando , Mendes Rubens Peres , Bittar Maurício José , de Freitas Silvio Henrique , Bernardino Thiago , Corrêa Rodrigo Romero 
Published: October 2024

AbstractThe dorsal and ventral nasal conchal bullae and conchal sinuses are part of the complex equine paranasal sinus system and are commonly affected by secondary sinusitis. However, the radiographic anatomy of the conchal sinuses is poorly reported in the literature. The present study aimed to describe the radiographic anatomical characteristics of the nasal conchal bullae and conchal sinuses in mature horses. Six equine cadaveric heads without sinus or dental disorders were studied. A maxillary sinusotomy was performed to identify the dorsal and ventral nasal conchal bullae and conchal sinuses, allowing the application of radiopaque contrast medium in these structures. Afterward, the same projections were repeated. Laterolateral views allowed an adequate visualization of nasal conchal bullae and conchal sinuses; however, they overlapped the same contralateral structure. In the latero30°dorsal–
lateroventral oblique view, the same structures were easily recognizable, but in an oblique view, the structures were projected dorsally in relation to the contralateral one. The dorsoventral view allowed partial visualization of the dorsal conchal bullae and dorsal sinuses, but it was not possible to identify the ventral conchal sinus and ventral conchal bullae. The offset dorsoventral view helped in the identification of the dorsal conchal bullae and dorsal conchal sinus, also achieving visualization of the medial region of the ventral conchal sinus and ventral conchal bullae. The use of contrast medium, added to the anatomical dissection, allowed a better radiographic identification of the sinuses and conchal bullae. The combination of different radiographic views is recommended for the evaluation of these structures.
Preliminary in vivo investigation of the mesenchymal stromal cell secretome as a novel treatment for methicillin‐resistant Staphylococcus aureus in equine skin wounds
Authors: Fahey Megan J. , Harman Rebecca M. , Thomas Matthew A. , Pugliese Brenna R. , Peters‐Kennedy Jeanine , Delco Michelle L. , Van de Walle Gerlinde R. 
Published: October 2024

AbstractObjectiveWe aimed to study the antimicrobial and pro‐healing potential of equine mesenchymal stromal cell secreted products (i.e. secretome), collected as conditioned media (mesenchymal stromal cell‐conditioned media, MSC CM), in a novel in vivo model of methicillin‐resistant Staphylococcus aureus (MRSA)‐inoculated equine thorax wounds.Study designProspective in vivo study.AnimalsTwo Thoroughbred geldings.MethodsSix full‐thickness cutaneous wounds were created bilaterally on the dorsal thorax of two horses (n = 12 wounds/horse). Wounds on the left thoraces were inoculated with MRSA on day 0. All wounds were then treated with either mupirocin ointment, MSC CM, or vehicle control (n = 4 wounds per group) once daily for 3 days. Photographs were taken to quantify wound scores and sizes, as well as samples to determine bacterial colony forming units (CFUs), at days 0, 1, 2, 3, 7, 14, 21, and 28. The wound edge was biopsied on days 0, 7, and 28, and scored histologically.ResultsInoculated wounds had more bacterial CFUs at day 1 (p < .0001) and were larger in size at day 28 (p = .0009) than noninoculated wounds. Mupirocin‐treated wounds were smaller than MSC CM and vehicle control‐treated wounds at day 28 (p = .003). Mesenchymal stromal cell‐conditioned media did not affect CFU numbers in inoculated and noninoculated wounds. Moreover, MSC CM did not affect the parameters of wound size or gross or microscopic wound scores over time.ConclusionMesenchymal stromal cell‐conditioned media did not exhibit antimicrobial or pro‐healing properties in the current study; however, the in vivo model of inoculated equine thorax wounds requires further optimization.Clinical significanceThis pilot study contributes to a growing understanding of the equine MSC secretome as an antimicrobial and pro‐healing therapeutic for equine wounds.
Description of a cricotracheostomy technique for permanent tracheostomy in eight dogs
Authors: Pieczynski Jordan D. , Stanley Bryden J. , Ham Kathleen M. 
Published: October 2024

AbstractObjectiveTo describe and report the outcome of a cricotracheostomy (CT) technique for the creation of a permanent upper airway ventral cervical stoma in dogs.Study designShort case series.AnimalsEight client‐owned dogs.MethodsUpper airway obstruction due to various disease processes was confirmed via upper airway examination and appropriate imaging. Medical records were reviewed to assess complications experienced during and following permanent CT. Owner questionnaires regarding quality of life (QoL) following permanent CT were performed.ResultsAll dogs experienced a routine recovery. The CT provided a robust dorsolateral. wall to the stoma from the cricoid cartilage. The stomata did not show any evidence of dorsal wall collapse or stenosis. Four dogs required further skin fold resection. The high position of this stoma also appears to be appropriate functionally with bilateral cervical skin fold resections. The owner questionnaires reported high satisfaction in the postoperative QoL.ConclusionCT was feasible and led to a reliable outcome for surgical patients and improvement in QoL. Comparative clinical investigation of the CT technique with traditional permanent tracheostomy techniques is indicated to definitively prove the validity and any superiority of the CT technique.
The anisotropic Calderón problem at large fixed frequency on manifolds with invertible ray transform
Authors: Ma Shiqi , Sahoo Suman Kumar , Salo Mikko 
Published: October 2024

AbstractWe consider the inverse problem of recovering a potential from the Dirichlet to Neumann map at a large fixed frequency on certain Riemannian manifolds. We extend the earlier result of Uhlmann and Wang [arXiv:2104.03477] to the case of simple manifolds, and more generally to manifolds where the geodesic ray transform is stably invertible. The argument involves an invariantly formulated construction of Gaussian beam quasimodes with uniform bounds for the underlying constants.
On the homology of big mapping class groups
Authors: Palmer Martin , Wu Xiaolei 
Published: October 2024

AbstractWe prove that the mapping class group of the one‐holed Cantor tree surface is acyclic. This in turn determines the homology of the mapping class group of the once‐punctured Cantor tree surface (i.e. the plane minus a Cantor set), in particular answering a recent question of Calegari and Chen. We in fact prove these results for a general class of infinite‐type surfaces called binary tree surfaces. To prove our results we use two main ingredients: one is a modification of an argument of Mather related to the notion of dissipated groups; the other is a general homological stability result for mapping class groups of infinite‐type surfaces.
A Network and Pathway Analysis of Genes Associated With Atrial Fibrillation
Authors: Zeng Mengying , Yang Xian , Chen Yunhao , Fan Jinqi , Cao Li , Wang Menghao , Xiao Peilin , Ling Zhiyu , Yin Yuehui , Chen Yunlin 
Published: October 2024

Background: Atrial fibrillation (AF) is affected by both environmental and genetic factors. Previous genetic association studies, especially genome‐wide association studies, revealed a large group of AF‐associated genes. However, little is known about the functions and interactions of these genes. Moreover, established genetic variants of AF contribute modestly to AF variance, implying that numerous additional AF‐associated genetic variations need to be identified. Hence, a systematic network and pathway analysis is needed.Methods: We retrieved all AF‐associated genes from genetic association studies in various databases and performed integrative analyses including pathway enrichment analysis, pathway crosstalk analysis, network analysis, and microarray meta‐analysis.Results: We collected 254 AF‐associated genes from genetic association studies in various databases. Pathway enrichment analysis revealed the top biological pathways that were enriched in the AF‐associated genes related to cardiac electromechanical activity. Pathway crosstalk analysis showed that numerous neuro‐endocrine‐immune pathways connected AF with various diseases including cancers, inflammatory diseases, and cardiovascular diseases. Furthermore, an AF‐specific subnetwork was constructed with the prize‐collecting Steiner forest algorithm based on the AF‐associated genes, and 24 novel genes that were potentially associated with AF were inferred by the subnetwork. In the microarray meta‐analysis, six of the 24 novel genes (APLP1, CREB1, CREBBP, PRMT1, IRAK1, and PLXND1) were expressed differentially in patients with AF and sinus rhythm.Conclusions: AF is not only an isolated disease with abnormal electrophysiological activity but might also share a common genetic basis and biological process with tumors and inflammatory diseases as well as cardiovascular diseases. Moreover, the six novel genes inferred from network analysis might help detect the missing AF risk loci.
Schopenhauer, Judicial Compassion, and the Case of Cecilia the Chimpanzee
Authors: Samamé Luciana 
Published: October 2024

Abstract
Over the last decades, a growing body of literature has focused on the role of compassion in legal decision making. To this respect, judicial compassion has been almost exclusively thematized in relation to human animals. In this paper, I claim that compassion shows itself especially relevant when judges should decide controversial cases involving animals. Drawing on Schopenhauer’s account of compassion, I contend that this emotion in particular can contribute to good decision making. To illustrate the argument, I analyze a renowned case from Argentinian jurisprudence: the case of Cecilia the chimpanzee.
Geographical distribution and molecular identification of cyst nematodes in Bajaur, Pakistan
Authors: Price James A. , Khanum Tabassum A. , Orr Jamie , Ullah Sami , Javed Salma 
Published: October 2024

Summary
A survey conducted along the Panjkora river in Bajaur, Khyber Pakhtunkhwa (KPK), Pakistan, identified seven isolates of nematode populations belonging to the Heteroderidae family among the 25 soil and root samples examined. Within these isolates, three were classified as Heterodera avenae, H. filipjevi and H. zeae, while the remaining four were identified as Globodera pallida. The identification of these cyst nematodes involved a combination of morphological and morphometric analyses, complemented by molecular techniques employing newly designed primers to amplify diagnostic regions from any cyst nematode. This study marks the first molecular characterisation of H. avenae, H. zeae and G. pallida in Pakistan and the initial report of H. filipjevi in the country. The mapping of crop-growing regions with sampling points highlights areas at high risk for further pathogen spread.
The Lexical and Syntactical Calque superaedificare in the Latin Tradition of the New Testament Epistles
Authors: Persig Anna 
Published: October 2024

Abstract
The prefixed verb superaedificare, which is a calque of ἐποικοδοµέω, governs prepositional phrases and plain cases in the Latin New Testament Epistles. The Vulgate and Old Latin manuscripts feature constructions of superaedificare in agreement with the Greek source text. However, alternative translations are attested when the biblical text is cited by early Christian writers. In citations where the biblical passage is included in the author’s text, aedificare is frequently used instead of superaedificare. By contrast, when the biblical text is quoted for the first time and its source is acknowledged, superaedificare is employed and its construction matches that of the Greek text. These citation habits show that the construction of superaedificare is a syntactical calque of the Greek source text, which is attested when the citations are marked as such but is not used when the biblical text is embedded in the patristic text.
Request for an Advisory Opinion Submitted by the Commission of Small Island States on Climate Change and International Law, Case 31
Authors: Freestone David , Schofield Clive , Barnes Richard , Akhavan Payam 
Published: October 2024

Abstract
On 21 May 2024, the International Tribunal on the Law of the Sea (ITLOS) delivered a ground-breaking and authoritative advisory opinion on States’ obligations under Part XII of the 1982 United Nations Convention on the Law of the Sea (LOSC). After confirming its jurisdiction over the request, ITLOS ruled that greenhouse gas emissions cause ‘deleterious effects on the marine environment’ and therefore constitute pollution under the LOSC. ITLOS explained the relationship between obligations under the LOSC and climate law and clarified the due diligence nature of the LOSC obligations to prevent marine pollution and to protect the marine environment.
“If You make these People Literate, You are undressing Me!”
Authors: Shelley Baskouda S.K. 
Published: October 2024

Abstract
This article discusses Jean-Marc Ela’s contribution to Kirdi empowerment in Tokombéré, Northern Cameroon, during the period 1970 and 1984. Drawing on ethnographic data, in-depth interviews and historical biography approach, the article argues that through a mixed methodology of fun, education and critical discourse towards authorities, Ela worked towards the awaking of the subalterns’ consciousness in Tokombéré.
Towards the Development of a Strategic Framework for Entrepreneurial Universities: A Case of Botswana Public Universities
Authors: Letsebe Lametse Nono , Ebewo Patrick Ebong , Nesamvuni AE 
Published: October 2024

Abstract
This study investigated the relevance of a triple helix model in the transition of public universities in Botswana into entrepreneurial universities. A qualitative study with 30 participants from four (4) public universities was conducted using a semi-structured interview. The sample was drawn from top management in each university using purposive and snowballing non-probability sampling techniques. Data was transcribed, coded and grouped into themes using Atlas ti software version 22. The study results revealed that the triple helix model was a relevant and applicable model for public universities in Botswana to transform into entrepreneurial universities. The relationship between academics, industry and government was found critical for the success of an entrepreneurial university. Even though this was the case, a unique finding specific to the Botswana context was that the model lacked the involvement of another key player, which was identified as the community. Hence, the study recommended a quadruple helix model. The study was the first to examine the relevance of a triple helix model in transforming public universities into entrepreneurial universities in Botswana.
Suspension of Judgment as a Doxastic Default
Authors: Satta Mark 
Published: October 2024

Abstract
In Outlines of Skeptical-Dogmatism, Mark Walker argues for Skeptical-Dogmatism about philosophical views—i.e., he argues that we should disbelieve most philosophical views. Walker argues for Skeptical-Dogmatism over both Dogmatism and Skepticism. In response, I defend Skepticism—i.e., the view that we should neither believe nor disbelieve most philosophical views. I argue that Walker’s arguments overlook some of the most plausible forms of philosophical Skepticism where the Skeptic suspends judgment about most disputed philosophical views without assigning a credence of 0.5 to those views. In doing so, I argue that suspension of judgment is the default justified doxastic attitude—i.e., the doxastic attitude one is epistemically justified in adopting absent any reason to do otherwise. I also champion Skepticism by offering modified versions of some of Walker’s thought experiments, posing challenges for Skeptical-Dogmatism, and arguing that Skepticism and Skeptical-Dogmatism share some common benefits.
Legalizing Bequests to Heirs in Egypt as a Legislative Application of Talfīq: towards a Purposive Interpretation of Article 37 of Law No. 71/1946
Authors: Fouad Ahmed 
Published: October 2024

Abstract
This paper tackles one example of interaction between state laws and social norms. It investigates the rationale behind the unprecedented legalization of bequeathing to heirs in Egypt that happened by the virtue of article 37 of law no. 71/1946. This article represents a legal rule that renegotiates a well settled matter in the Sunni jurisprudence based on an undefined common need that was alleged in the explanatory memorandum of this law. The paper investigates that common need through an originalist approach into the mentioned article then validates the output of that investigation by a review of relevant judicial rulings. As part of this originalist approach, the paper engages with the available data pertaining to the drafting process of law no. 71/1946, the key members in the drafting committee, and the parliamentary discussion on article 37 of the law. It also attempts a contextual reading for article 37 to understand its legal rationale and propose criteria for judicial enforcement that would maintain this rationale.
Arbitrability and Mediability of Disputes: The Iranian Perspective
Authors: Ghaffari Sima , Kashkouli Rasoul 
Published: October 2024

Abstract
There has been a growing trend in the use of alternative dispute resolution methods (“ADR”), particularly arbitration, on a global scale and Iran is no exception to this trend. In simple terms, arbitrability means that certain disputes may not be submitted to arbitration. Mirroring this concept, mediability refers to the capability of disputes to be resolved through mediation. The definition of arbitrability and mediability are subject to significant ambiguity, as there is currently no universally recognized and uniform standard for these concepts. In fact, national laws determine the definitions and concepts of arbitrability and mediability.
In order to gain a comprehensive understanding of the extent to which disputes are capable to be resolved through arbitration and mediation, it is necessary to initially examine the current legislative framework. The present article attempts to examine the arbitrability and mediability of disputes within the Iranian legal framework. In doing so, after recalling the background of ADR system in Iran in the first section, the second section will discuss the arbitrability with regard to arbitration-related laws. The third section will successively explore the arbitrability in Iranian legal jurisprudence, clarifying that while some disputes are not inherently non-arbitrable, there are certain limitations on their referral to arbitration. The fourth section will delve into the concept of mediability in Iran. Lastly, the fifth section will conclude the article by positioning the approach of the Iranian legal system towards arbitrability and mediability.
Implications of Islamic Mahr (dower) and African Lobolo (bride-price) on Religious and Customary Marriages and the Rights of Muslim Women to Inherit in South Africa
Authors: Moosa Najma 
Published: October 2024

Abstract
The monogamous and polygynous customary marriages of indigenous Black Africans have been fully legally recognised in South Africa since 1998. The outcome of a June 2022 apex Constitutional Court judgment will finally result in monogamous and polygynous Muslim marriages (nikāḥ) being fully legally recognized and regulated by the State by 2024. Since this recognition does not include the Islamic law of succession (which will not pass constitutional muster because of half-share to women), when Muslims die intestate, the secular law is expected to apply. The payment of mahr (dower) by the groom to the bride (an important ingredient of a nikāḥ contract) is therefore an important alternative tool for augmenting the inheritance of Muslim women during their lifetime. A novel fatwā issued by local Black African ulama in August 2022 brought to light several challenges faced by African Muslims regarding the relation of nikāḥ marriages to distinctive African traditional marriage practices like the lobolo (“bride price”) paid by the groom to the bride’s father. This paper examines the implications of mahr and lobolo on religious and customary marriages and the rights of local Black African Muslim women to inherit in terms of religion and custom.