bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported outcomes during first-line palliative systemic therapy alternated with pressurized intraperitoneal aerosol chemotherapy for unresectable colorectal peritoneal metastases: a single-arm phase II trial (CRC-PIPAC-II)
Authors: van de Vlasakker Vincent C. J. , Rauwerdink Paulien , Rovers Koen. P. B. , Wassenaar Emma C. , Creemers Geert-Jan , Los Maartje , Burger Jacobus . W. A. , Nienhuijs Simon W. , Kranenburg Onno , Wiezer Marinus J. , Lurvink Robin J. , Boerma Djamila , de Hingh Ignace H. J. T. 
Published: September 2024

Abstract
Background
The CRC-PIPAC-II study prospectively assessed bidirectional therapy (BT) consisting of first-line palliative systemic therapy and electrostatic precipitation oxaliplatin-based pressurized intraperitoneal aerosol chemotherapy (ePIPAC-OX) in patients with unresectable colorectal peritoneal metastases (CPM). This study describes the exploration of patient-reported outcomes (PROs).

Methods
In this phase II trial, 20 patients with isolated CPM were treated with up to three cycles of BT, each cycle consisting of two to three courses of systemic therapy, followed by ePIPAC-OX (92 mg/m2). Patients were asked to complete the EuroQoL EQ-5D-5L, EORTC QLQ-C30, and EORTC QLQ-CR29 questionnaires at baseline, during the first cycle of BT, and one and four weeks after each consecutive BT cycle. PRO scores were calculated and compared between baseline and each subsequent time point using linear-mixed modeling (LMM). PROs were categorized into symptom scales and function scales. Symptom scales ranged from 0 to 100, with 100 representing the maximum symptom load. Function scales ranged from 0 to 100, with 100 representing optimal functioning.

Results
Twenty patients underwent a total of 52 cycles of bidirectional therapy. Most PROs (29 of 37, 78%) were not significantly affected during trial treatment. In total, only eight PROs (22%) were significantly affected during trial treatment: Six PROs (index value, global health status, emotional functioning, C30, appetite, and insomnia) showed transient improvement at different time points. Two PROs transiently deteriorated: pain initially improved during the first BT cycle [− 16, p < 0.001] yet worsened temporarily one week after the first two BT cycles (+ 20, p < 0.001; + 17, p = 0.004; respectively). Abdominal pain worsened temporarily one week after the first BT cycle (+ 16, p = 0.004), before improving again four weeks after treatment ended (− 10, p = 0.004). All significant effects on Pros were clinically significant and all deteriorations in PROs were of temporary nature.

Discussion
Patients undergoing BT for unresectable CPM had significant, but reversible alterations in several PROs. Most affected PROs concerned improvements and only two PROs showed deteriorations. Both deteriorated PROs returned to baseline after trial treatment and were of a temporary nature. These outcomes help to design future studies on the role of ePIPAC in the palliative setting.
A calculator for musculoskeletal injuries prediction in surgeons: a machine learning approach
Authors: Sánchez-Guillén Luis , Lozano-Quijada Carlos , Soler-Silva Álvaro , Hernández-Sánchez Sergio , Barber Xavier , Toledo-Marhuenda José V. , López-Rodríguez-Arias Francisco , Poveda-Pagán Emilio J. , Mora César González , Arroyo Antonio 
Published: September 2024

Abstract
Background
Surgical specialists experience significant musculoskeletal strain as a consequence of their profession, a domain within the healthcare system often recognized for the pronounced impact of such issues. The aim of this study is to calculate the risk of presenting musculoskeletal injuries in surgeons after surgical practice.

Methods
Cross-sectional study carried out using an online form (12/2021–03/2022) aimed at members of the Spanish Association of Surgeons. Demographic variables on physical and professional activity were recorded, as well as musculoskeletal pain (MSP) associated with surgical activity. Univariate and multivariate analysis were conducted to identify risk factors associated with the development of MSP based on personalized surgical activity. To achieve this, a risk algorithm was computed and an online machine learning calculator was created to predict them. Physiotherapeutic recommendations were generated to address and alleviate each MSP.

Results
A total of 651 surgeons (112 trainees, 539 specialists). 90.6% reported MSP related to surgical practice, 60% needed any therapeutic measure and 11.7% required a medical leave. In the long term, MSP was most common in the cervical and lumbar regions (52.4, 58.5%, respectively). Statistically significant risk factors (OR CI 95%) were for trunk pain, long interventions without breaks (3.02, 1.65–5.54). Obesity, indicated by BMI, to lumbar pain (4.36, 1.84–12.1), while an inappropriate laparoscopic screen location was associated with cervical and trunk pain (1.95, 1.28–2.98 and 2.16, 1.37–3.44, respectively). A predictive model and an online calculator were developed to assess MSP risk. Furthermore, a need for enhanced ergonomics training was identified by 89.6% of surgeons.

Conclusions
The prevalence of MSP among surgeons is a prevalent but often overlooked health concern. Implementing a risk calculator could enable tailored prevention strategies, addressing modifiable factors like ergonomics.
The Arabidopsis KASH protein SINE3 is involved in male and female gametogenesis
Authors: Moser Morgan , Groves Norman R. , Meier Iris 
Published: September 2024

Key message
The Arabidopsis KASH protein SINE3 is involved in male and female gametophyte development, likely affecting the first post-meiotic mitosis in both cases, and is required for full seed set.

Abstract
Linker of nucleoskeleton and cytoskeleton (LINC) complexes are protein complexes spanning the inner and outer membranes of the nuclear envelope (NE) and are key players in nuclear movement and positioning. Through their roles in nuclear movement and cytoskeletal reorganization, plant LINC complexes affect processes as diverse as pollen tube rupture and stomatal development and function. KASH proteins are the outer nuclear membrane component of the LINC complex, with conserved C-termini but divergent N-terminal cytoplasmic domains. Of the known Arabidopsis KASH proteins, SUN-INTERACTING NUCLEAR ENVELOPE PROTEIN 3 (SINE3) has not been functionally characterized. Here, we show that SINE3 is expressed at all stages of male and female gametophyte development. It is located at the NE in male and female gametophytes. Loss of SINE3 results in a female-derived seed set defect, with sine3 mutant ovules arresting at stage FG1. Pollen viability is also significantly reduced, with microspores arresting prior to pollen mitosis I. In addition, sine3 mutants have a minor male meiosis defect, with some tetrads containing more than four spores. Together, these results demonstrate that the KASH protein SINE3 plays a crucial role in male and female gametophyte development, likely affecting the first post-meiotic nuclear division in both cases.
Accurate Simulation of Efimov Physics in Ultracold Atomic Gases with Realistic Three-Body Multichannel Interactions
Authors: Kraats J. van de , Kokkelmans S. J. J. M. F. 
Published: September 2024

AbstractWe give a detailed and self-contained description of a recently developed theoretical and numerical method for the simulation of three identical bosonic alkali-metal atoms near a Feshbach resonance, where the Efimov effect is induced. The method is based on a direct construction of the off-shell two-body transition matrix from exact eigenfunctions of the embedded two-body Hamiltonians, obtained using realistic parameterizations of the interaction potentials which accurately reproduce the molecular energy levels. The transition matrix is then inserted into the appropriate three-body integral equations, which may be efficiently solved on a computer. We focus especially on the power of our method in including rigorously the effects of multichannel physics on the three-body problem, which are usually accounted for only by various approximations. We demonstrate the method for 7Li, where we recently showed that a correct inclusion of this multichannel physics resolves the long-standing disagreement between theory and experiment regarding the Efimovian three-body parameter. We analyze the Efimovian enhancement of the three-body recombination rate on both sides of the Feshbach resonance, revealing strong sensitivity to the spin structure of the model thus indicating the prevalence of three-body spin-exchange physics. Finally, we discuss an extension of our methodology to the calculation of three-body bound-state energies.
Wnt family members regulating osteogenesis and their origins
Authors: Kobayashi Yasuhiro , Iwamoto Rina , He Zhifeng , Udagawa Nobuyuki 
Published: September 2024

AbstractWnt signaling plays an important role in the regulation of bone metabolism. Wnt activates the β-catenin-mediated canonical pathway and β-catenin-independent non-canonical pathway. When Wnt ligands bind to the co-receptors low density lipoprotein receptor-related protein (Lrp)5 or Lrp6, and a seven-transmembrane receptor frizzled, the canonical pathway is activated. On the other hand, when Wnt ligands bind to the receptor complex consisting of the co-receptor receptor tyrosine kinase-like orphan receptor (Ror)1 and Ror2 or Ryk and frizzled, the non-canonical pathway is activated. An analysis of loss-of-function and gain-of-function mutations in molecules involved in Wnt signaling (ligands, receptors, and inhibitors) has revealed the mechanisms by which Wnt signaling regulates bone metabolism. In this review, based on transcriptome analyses of Wnt expression in bone tissues including single cell RNA sequence analysis and previous literatures, we herein introduce and discussed the latest findings on the mechanisms by which Wnt ligand mutations impair bone metabolism, especially bone formation.
A versatile framework for attributed network clustering via K-nearest neighbor augmentation
Authors: Li Yiran , Guo Gongyao , Shi Jieming , Yang Renchi , Shen Shiqi , Li Qing , Luo Jun 
Published: September 2024

AbstractAttributed networks containing entity-specific information in node attributes are ubiquitous in modeling social networks, e-commerce, bioinformatics, etc. Their inherent network topology ranges from simple graphs to hypergraphs with high-order interactions and multiplex graphs with separate layers. An important graph mining task is node clustering, aiming to partition the nodes of an attributed network into k disjoint clusters such that intra-cluster nodes are closely connected and share similar attributes, while inter-cluster nodes are far apart and dissimilar. It is highly challenging to capture multi-hop connections via nodes or attributes for effective clustering on multiple types of attributed networks. In this paper, we first present as an efficient approach to attributed hypergraph clustering (AHC). includes a carefully-crafted K-nearest neighbor augmentation strategy for the optimized exploitation of attribute information on hypergraphs, a joint hypergraph random walk model to devise an effective AHC objective, and an efficient solver with speedup techniques for the objective optimization. The proposed techniques are extensible to various types of attributed networks, and thus, we develop as a versatile attributed network clustering framework, capable of attributed graph clustering, attributed multiplex graph clustering, and AHC. Moreover, we devise with algorithmic designs tailored for GPU acceleration to boost efficiency. We have conducted extensive experiments to compare our methods with 19 competitors on 8 attributed hypergraphs, 16 competitors on 6 attributed graphs, and 16 competitors on 3 attributed multiplex graphs, all demonstrating the superb clustering quality and efficiency of our methods.
Towards Sustainability of AI – Identifying Design Patterns for Sustainable Machine Learning Development
Authors: Leuthe Daniel , Meyer-Hollatz Tim , Plank Tobias , Senkmüller Anja 
Published: September 2024

Abstract
As artificial intelligence (AI) and machine learning (ML) advance, concerns about their sustainability impact grow. The emerging field "Sustainability of AI" addresses this issue, with papers exploring distinct aspects of ML’s sustainability. However, it lacks a comprehensive approach that considers all ML development phases, treats sustainability holistically, and incorporates practitioner feedback. In response, we developed the sustainable ML design pattern matrix (SML-DPM) consisting of 35 design patterns grounded in justificatory knowledge from research, refined with naturalistic insights from expert interviews and validated in three real-world case studies using a web-based instantiation. The design patterns are structured along a four-phased ML development process, the sustainability dimensions of environmental, social, and governance (ESG), and allocated to five ML stakeholder groups. It represents the first artifact to enhance each ML development phase along each ESG dimension. The SML-DPM fuels advancement by aggregating distinct research, laying the groundwork for future investigations, and providing a roadmap for sustainable ML development.
Elizabeth Acevedo, Laura Esquivel, and the Politics of Multilingualism
Authors: Manizza Roszak Suzanne 
Published: September 2024

AbstractA number of bloggers, journalists, teachers, and librarians have compared Elizabeth Acevedo’s 2019 young adult novel With the Fire on High with Laura Esquivel’s Como agua para chocolate (1989), recommending that fans of Esquivel’s work pick up Acevedo’s—and vice versa. These suggestions echo Acevedo’s own comments about the narrative, which she has characterized as “parecido a ‘Como agua para chocolate,’ pero en el barrio” (Acevedo & Pichardo, 2019). This article takes this recent reception history as an invitation to think through how With the Fire on High deepens and course-corrects the revolutionary path of Esquivel’s earlier text. More specifically, I interrogate how Acevedo and Esquivel engage with linguistic identities and with multilingualism in particular as source material for political resistance and healing. Acevedo, like Esquivel before her, represents multilingual identities in ways that disrupt and resist the neocolonial violence of the United States. However, whereas Como agua para chocolate’s references to minoritized languages are executed in a manner that threatens to reinscribe traumatizing ethnoracial and class hierarchies passed down via colonial history, multilingualism in Acevedo’s novel works more systemically to intervene in and undermine such established matrices of power. Acevedo participates in a project of linguistic resistance and healing that involves reclaiming a heritage language for a multiply marginalized protagonist and, through that act of reclamation, rejecting the received cultural wisdom propagated by both colonial and neocolonial systems.
World wetlands classification: a new hierarchic hydro-ecological approach
Authors: Junk Wolfgang J. 
Published: September 2024

AbstractMany different approaches to classify wetlands at regional and global levels have been proposed, but their use of different classification parameters complicates comparisons of the results. Moreover, none of the international approaches cover global wetland variety with respect to size and environmental conditions. A comparison shows that hydrology is the only parameter that can be used for a hierarchic classification on a global scale. In the approach presented herein, differentiation between coastal, inland and anthropogenic wetlands is proposed. The use of higher classification units (systems, subsystems, orders, suborders and classes) is based on hydrological parameters. Wetlands are separated into small, simply structured types treated by all classification systems, and large wetscapes that, due to their complexity, are not. However, wetscapes represent well-defined landscape units, many of which are the focus of international organizations involved in wetland protection. They have to be treated using a holistic approach given the many interactions of their ecological subunits, their role in regional economies, their targeting by legislation and their value to humans. Considering the large gaps in knowledge about wetlands at a global scale, the new approach is a powerful tool for its classification, because it is flexible enough to include additional classification units, as required. Local classification systems can eliminate higher categories, which do not occur in their regions. Classification at lower rankings (functional units, subclasses, macrohabitats) can be introduced using additional classification parameters such as vegetation, soils and water chemistry. Examples from Brazil are provided.
Real world challenges and barriers for positive airway therapy use in acute ischemic stroke patients
Authors: Pascoe Maeve , Grigg-Damberger Madeleine M , Walia Harneet , Andrews Noah , Wang Lu , Bena James , Katzan Irene , Uchino Ken , Foldvary-Schaefer Nancy 
Published: September 2024

Abstract
Purpose
Untreated obstructive sleep apnea (OSA) in patients with acute ischemic stroke (AIS) is associated with increased morbidity and mortality. However, diagnosing and treating OSA in AIS is challenging. We aimed to determine the feasibility of portable monitoring (PM) for diagnosis and positive airway pressure therapy for treatment of OSA in an inpatient stroke population.

Methods
We recruited inpatients with AIS from Cleveland Clinic. Those who consented underwent PM; participants with a respiratory event index (REI) ≥ 10 were offered auto-titrating positive airway pressure therapy (APAP). Ease-of-use questionnaires were completed. We summarized categorical variables using n(%) and continuous variables using mean ± SD or median [IQR].

Results
27 participants (age 59.8 ± 11.8, 51.9% female, 51.9% Black, BMI 33.4 ± 8.5) enrolled. The study ended early due to Medicare contracting that forced most patients to complete stroke rehabilitation outside the Cleveland Clinic health system. 59.3% had large vessel occlusions and 53.8% had moderate/severe disability (Modified Rankin score ≥ 2). PM was attempted in 21 participants, successful in 18. Nurses and patients rated the PM device as highly easy to use. 13 of 18 (72%) patients who had an REI ≥ 10 consented to APAP titration, but only eight (61.5%) of those 13 used APAP for more than one night, and only five (27.8%) used APAP up to 90 days with data captured for only one participant. Five required troubleshooting at titration, and only one had adherent APAP usage by objective assessment after discharge.

Conclusions
This study demonstrates the real-world challenges of assessing and treating OSA in an AIS population, highlighting the necessity for further research into timely and feasible screening and treatment.
Mathematical model of dating apps’ influence on sexually transmitted diseases spread
Authors: Lazebnik Teddy 
Published: September 2024

Abstract
Sexually transmitted diseases (STDs) are a group of pathogens infecting new hosts through sexual interactions. Due to its social and economic burden, multiple models have been proposed to study the spreading of pathogens. In parallel, in the ever-evolving landscape of digital social interactions, the pervasive utilization of dating apps has become a prominent facet of modern society. Despite the surge in popularity and the profound impact on relationship formation, a crucial gap in the literature persists regarding the potential ramifications of dating apps usage on the dynamics of STDs. In this paper, we address this gap by presenting a novel mathematical framework - an extended Susceptible-Infected-Susceptible (SIS) epidemiological model to elucidate the intricate interplay between dating apps engagement and the propagation of STDs. Namely, as dating apps are designed to make users revisit them and have mainly casual sexual interactions with other users, they increase the number of causal partners, which increases the overall spread of STDS. Using extensive simulation, based on real-world data, explore the effect of dating apps adoption and control on the STD spread. We show that an increased adoption of dating apps can result in an STD outbreak if not handled appropriately.
Long/post-COVID in children and adolescents: symptom onset and recovery after one year based on healthcare records in Germany
Authors: Ehm Franz , Tesch Falko , Menzer Simone , Loser Friedrich , Bechmann Lars , Vivirito Annika , Wende Danny , Batram Manuel , Buschmann Tilo , Ludwig Marion , Roessler Martin , Seifert Martin , Sarganas Margolis Giselle , Reitzle Lukas , Koenig Christina , Schulte Claudia , Ballesteros Pedro , Bassler Stefan , Bitterer Thomas , Riederer Cordula , Berner Reinhard , Scheidt-Nave Christa , Schmitt Jochen , Toepfner Nicole 
Published: September 2024

Abstract

Purpose
Evidence on the incidence and persistence of post-acute sequelae of COVID-19 (PASC) among children and adolescents is still limited.

Methods
In this retrospective cohort study, 59,339 children and adolescents with laboratory-confirmed COVID-19 in 2020 and 170,940 matched controls were followed until 2021-09-30 using German routine healthcare data. Incidence rate differences (ΔIR) and ratios (IRR) of 96 potential PASC were estimated using Poisson regression. Analyses were stratified according to age (0–11, 12–17 years), and sex. At the individual level, persistence of diagnoses in patients with onset symptoms was tracked starting from the first quarter post-infection.

Results
At 0–3 month follow-up, children and adolescents with a previous SARS-CoV-2 infection showed a 34% increased risk of adverse health outcome, and approximately 6% suffered from PASC in association with COVID-19. The attributable risk was higher among adolescents (≥ 12 years) than among children. For most common symptoms, IRRs largely persisted at 9–12 month follow-up. IRR were highest for rare conditions strongly associated with COVID-19, particularly inflammatory conditions among children 0–11 years, and chronic fatigue and respiratory insufficiency among adolescents. Tracking of diagnoses at the individual level revealed similar rates in the decline of symptoms among COVID-19 and control cohorts, generally leaving less than 10% of the patients with persistent diagnoses after 12 months.

Conclusion
Although very few patients presented symptoms for longer than 12 months, excess morbidity among children and, particularly, adolescents with a history of COVID-19 means a relevant burden for pediatric care.