bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heated or raw Blue cheeses: what are the drivers influencing consumer preferences?
Authors: Bord Cécile , Guerinon Delphine , Lebecque Annick 
Published: May 2017

AbstractSix French Blue cheeses (two cheese types of varying ripening times) were evaluated under two treatment conditions, raw cheeses (without heating) and heated cheeses (with heating), in order to describe the sensory properties of raw and heated cheeses and to identify the sensory keys drivers of liking and disliking that explain consumer preference patterns. A trained panel performed sensory profiles of selected cheeses. In parallel, 153 French consumers evaluated the same cheeses for overall liking and intensity of gustatory attributes, coupled with open‐ended questions. Descriptive analysis revealed a clear distinction between the two treatment conditions. In addition, three clusters of consumers were identified with distinctive preference profiles. One of the clusters, including about 25% of consumers, clearly preferred cheeses with a high flavour intensity whatever the treatment conditions. A second cluster, 50% of consumers, liked only heated cheeses, for which texture and appearance were determined as drivers of liking. The third cluster preferred cheeses with a slight flavour intensity whatever the treatment conditions.
Effect of butter content and baking condition on characteristics of the gluten‐free dough and bread
Authors: Srikanlaya Chonnikarn , Therdthai Nantawan , Ritthiruangdej Pitiporn , Zhou Weibiao 
Published: May 2017

SummaryThis study aimed to investigate effect of butter content (0–30 g/100 g flour) and baking conditions hot air baking (HA), microwave baking (MW) and hot air‐microwave baking (HA‐MW) on quality of the rice flour dough and bread. The increased butter (up to 15 g butter/100 g flour) enhanced elastic modulus (G′) and viscous modulus (G″) of dough and specific volume of bread. Additionally, the increased butter improved crust colour and reduced hardness of the bread. The HA‐MW and MW conditions were useful for the gluten‐free bread by reducing baking time and predicted glycemic index (GI), regardless of butter content. However, enthalpy of retrogradation and crystallinity in the HA‐MW and MW bread stored at 4 °C for 7 days were increased and higher than those of the HA bread, indicating a faster staling. The predicted GI of both MW and HA‐MW bread remained at a medium level during storage.
Optimised condition for preparing sea cucumber ovum hydrolysate–calcium complex and its structural analysis
Authors: Cui Pengbo , Sun Na , Jiang Pengfei , Wang Di , Lin Songyi 
Published: May 2017

SummaryThis study aimed to determine optimum preparation conditions of sea cucumber ovum hydrolysates–calcium (SCOHs–Ca) complexes by Box–Behnken design and further elucidate their microstructure characteristics using Fourier transform infrared spectroscopy, scanning electron microscope, atomic force microscopy and dynamic light scattering. The predicted calcium‐chelating capacity under the optimum conditions of the process variables was very close to the experimental value (53.45 ± 0.29 mg g−1) determined in the batch experiment. Results demonstrated that the calcium bind to the SCOHs to form the SCOHs–Ca complexes primarily via interactions with carboxyl oxygen and amino nitrogen atoms. The prepared SCOHs–Ca complexes formed compact nanoparticles and exhibited a fold and porous network structure. These changes could be attributed to the interaction between peptides and calcium ions. Our findings provide a theoretical basis for the development of new calcium preparations as well as the high‐value utilisation of sea cucumber by‐products.
Selection of reference genes for quantitative real‐time PCR in postharvest tomatoes (Lycopersicon esculentum) treated by continuous low‐voltage direct current electricity to increase secondary metabolites
Authors: Leelatanawit Rungnapa , Saetung Thunyarat , Phuengwas Sudtida , Karoonuthaisiri Nitsara , Devahastin Sakamon 
Published: May 2017

SummaryQuantitative real‐time PCR (RT‐qPCR) is often used for gene expression analysis to reveal molecular mechanism of how stresses can enhance the secondary metabolites production. For RT‐qPCR to be valid, robust reference genes are required. This study validated nine candidate genes as reference genes using BestKeeper, NormFinder and geNorm methods in RT‐qPCR analysis of postharvest tomatoes subjected to electricity‐induced stress. The most stable genes as indicated by each method were EF‐1α by BestKeeper; CAC by NormFinder; and PP2Acs/TIP41 by geNorm. Due to the inconsistency in the ranking of the candidate genes by the three methods, the pairwise variation from geNorm analysis was used to calculate the minimum numbers of reference genes for an accurate normalisation and revealed that a combination of PP2Acs and TIP41 was an optimum. This reference gene combination was further validated for their stability in RT‐qPCR analysis of four carotenoid‐related genes, and more reliable expression levels were obtained.
Community football teams for people with intellectual disabilities in secure settings: “They take you off the ward, it was like a nice day, and then you get like medals at the end”
Authors: Hudson Nicholas Andrew , Mrozik Jennifer Hella , White Rose , Northend Kristian , Moore Steve , Lister Katherine , Rayner Kelly 
Published: May 2017

BackgroundPeople with learning disabilities (LD) are particularly vulnerable to mental health and behavioural difficulties, and it has been shown that regular exercise can improve psychosocial well‐being as well as physical fitness. This research aims to explore the experiences of men with LD detained in secure settings who have engaged in community football training programmes and identify the benefits of such provision.MethodInterviews were conducted with eight patients in a forensic LD service, discussing their experiences of participating in community football. Template analysis was undertaken on the transcripts.ResultsTwo master themes were identified: physical fitness and psychosocial benefits. As the analysis progressed, new emerging themes were identified around role identity and achievement, as well as extending and refining some of the themes from the original template including fun and belonging. Some anticipated themes were removed from the template entirely.ConclusionThe psychosocial benefits of organised community sports programmes far outweigh the physical health benefits. Careful consideration must be given to where on a treatment and rehabilitation pathway non‐traditional therapeutic interventions such as sports programmes are offered as an adjunct to specific risk reduction interventions for people with LD in secure settings.
Dysregulation of the MEK/ERK/MNK1 signalling cascade by middle T antigen of the trichoydsplasia spinulosa polyomavirus
Authors: Wu J.H. , Narayanan D. , Simonette R.A. , Rady P.L. , Tyring S.K. 
Published: May 2017

AbstractBackgroundTrichodysplasia spinulosa (TS) is a disfiguring folliculocentric cutaneous disease caused by infection with the trichodysplasia spinulosa polyomavirus (TSPyV). The TSPyV genome contains splice variants encoding the middle tumour (mT) antigen, although the potential role for TSPyV mT antigen in disease development remains unknown.ObjectiveThe current study was designed to investigate the mechanistic properties of TSPyV mT antigen, which may further our understanding of TS pathogenesis and provide insight into potential therapies.MethodsA lentiviral packaging system was used to create an inducible cell line expressing TSPyV mT antigen. Proteins were extracted, separated by SDS‐PAGE and subjected to Western blot analysis. Co‐immunoprecipitation experiments and mutational analyses were also performed to evaluate protein–protein interactions of mT antigen.ResultsWe describe a novel mechanism of action for mT antigen that involves hyperactivation of MEK, ERK and MNK1. Our findings suggest that dysregulation of these key signalling molecules depends upon TSPyV mT antigen interaction with protein phosphatase 2A (PP2A) via intact Zn binding motifs.ConclusionGiven that PP2A interaction and MEK/ERK/MNK1 phosphorylation are associated with high levels of cell proliferation and inflammation, our findings provide new evidence that TSPyV mT antigen may contribute to the pro‐proliferative conditions that lead to TS development.
Continuous Material Flow Analysis Approach for Bulk Nonmetallic Mineral Building Materials Applied to the German Building Sector
Authors: Schiller Georg , Gruhler Karin , Ortlepp Regine 
Published: May 2017

SummaryMaterial flow analysis (MFA) is a helpful tool to understand and develop the circular economy. There exist a number of MFA models to depict inflows and outflows of bulk nonmetallic mineral building materials, which are, in fact, the largest flows in terms of tonnes. However, until now such models have not attempted to directly link inflows and outflows. In order to achieve such closed loops, it is necessary to consider the qualitative aspects of inflows and outflows as well as quantities. The technical possibilities of recycling are, in fact, determined by both the quality and quantity of materials. This requires the integration of knowledge on process engineering, the technology of waste management, and indeed the structure of buildings. The article integrates these aspects within a continuous MFA approach (C‐MFA), which is able to analyze and quantify the entire material cycle of bulk nonmetallic mineral building materials by considering the use of recycled aggregates in concrete building elements. This is achieved by methodological expansions that take into account qualitative aspects with regard to outflows and inflows. The approach is applied to questions of high‐quality recycling within the German building stock. The continuity of construction and demolition waste output and secondary material input is realized by integrating the process steps required to capture high‐quality waste in the course of building demolition, material processing of the material to produce recycled aggregates, and admixing of the aggregates to produce new concrete used in buildings. This can be extended by considering the inflows and outflows of other sectors, for example, the infrastructure sector. The main outcome is an extended C‐MFA approach that enables quantification of sectoral as well as, in principle, intersectoral material loops of bulk nonmetallic mineral building materials while uncovering potentials to save natural resources as well to better exploit anthropogenic resources.
The effect of autologous activated platelet‐rich plasma injection on female pattern hair loss: A randomized placebo‐controlled study
Authors: Tawfik Abeer Attia , Osman Mai Abdel Raouf 
Published: May 2017

SummaryBackgroundHair is an essential part of a woman's appearance and attractiveness. This is reflected in the predominantly psychological morbidity that can be associated with female pattern hair loss. Platelet‐rich plasma(PRP) has been used in numerous fields of medicine. Recently, PRP has received growing attention as a potential therapeutic tool for hair loss.ObjectiveTo evaluate the efficacy and safety of autologous platelet‐rich plasma in the treatment of female pattern hair loss.Materials and methodsThirty female patients with female pattern hair loss were randomly assigned to receive autologous PRP injection into a selected area, and another area was injected with normal saline as a placebo. Sessions were performed weekly for a maximum total of four sessions. Patients were followed up 6 months after the end of last session. The outcome was assessed both subjectively and objectively.ResultsThere was a statistical significant difference between PRP and placebo areas (P<.005) regarding both hair density and hair thickness as measured by a folliscope. The hair pull test became negative in PRP‐injected areas in 25 patients (83%) with average number of three hairs. Global pictures showed a significant improvement in hair volume and quality together with a high overall patient satisfaction in PRP‐injected sites, and these results were maintained during the 6‐month follow‐ up.ConclusionPlatelet‐rich plasma injections can be regarded as an alternative for the treatment of female pattern hair loss with minimal morbidity and a low cost‐to‐benefit ratio.
The Front Men of Wall Street: The Role of CDO Collateral Managers in the CDO Boom and Bust
Authors: CHERNENKO SERGEY 
Published: May 2017

ABSTRACTI study the incentives of the collateral managers who selected securities for ABS CDOs—securitizations that figured prominently in the financial crisis. Specialized managers without other businesses that could suffer negative reputational consequences invested in low‐quality securities underwritten by the CDO's arranger. These securities performed significantly worse than observationally similar securities. Managers investing in these securities were rewarded with additional collateral management assignments. Diversified managers who did assemble CDOs suffered negative reputational consequences during the crisis: institutional investors withdrew from their mutual funds. Overall, the results are consistent with a quid pro quo between collateral managers and CDO underwriters.
Consumer Default, Credit Reporting, and Borrowing Constraints
Authors: GARMAISE MARK J. , NATIVIDAD GABRIEL 
Published: May 2017

ABSTRACTWhy do negative credit events lead to long‐term borrowing constraints? Exploiting banking regulations in Peru and utilizing currency movements, we show that consumers who face a credit rating downgrade due to bad luck experience a three‐year reduction in financing. Consumers respond to the shock by paying down their most troubled loans, but nonetheless end up more likely to exit the credit market. For a set of borrowers who experience severe delinquency, we find that the associated credit reporting downgrade itself accounts for 25% to 65% of their observed decline in borrowing at various horizons over the following several years.
Effect of the injectable contraceptive depot‐medroxyprogesterone acetate on coagulation parameters in new users
Authors: Melhado‐Kimura Vaneska , Bizzacchi Joyce Maria Annichino , Quaino Susan Kelly Picoli , Montalvao Silmara , Bahamondes Luis , Fernandes Arlete 
Published: May 2017

AbstractAimThe aim of this study was to assess the effects of the injectable depot‐medroxyprogesterone acetate (DMPA) contraceptive on selected blood coagulation parameters in young, healthy new users.MethodsThe prospective study included 39 healthy women aged 20–39 years, with a body mass index (BMI; kg/m2) < 30, who were never users of DMPA, and who opted to use DMPA (21 women) or a copper intrauterine device (IUD; 18 women). The women in the two groups were matched for age (±1 year) and BMI (±1). Blood samples were obtained from all participants at baseline and at 6 and 12 months. Activated partial thromboplastin time, D‐dimer, protein C, antithrombin, protein S, and thrombin generation test (lag time, endogenous thrombin potential, time to peak, and velocity index of thrombin generation) were analyzed. Repeated‐measures analysis of variance was used to compare the groups.ResultsThere were no significant differences between the groups at baseline with respect to any of the parameters evaluated; however, in the DMPA group, D‐dimer levels were lower and the time to peak thrombin generation was longer than in the IUD group at 12 months of evaluation.ConclusionLower D‐dimer and longer time to peak thrombin generation in new users of DMPA suggest a positive profile against hypercoagulability.
Normal amniotic fluid volume across gestation: Comparison of statistical approaches in 1190 normal amniotic fluid volumes
Authors: Ounpraseuth Songthip T. , Magann Everett F. , Spencer Horace J. , Rabie Nader Z. , Sandlin Adam T. 
Published: May 2017

AbstractAimUltrasound estimation and evaluation of amniotic fluid volume (AFV) is an important component of pregnancy surveillance and fetal well‐being. The purpose of this study was to compare and contrast four statistical methods used to construct gestational age‐specific reference intervals for the assessment of AFV.MethodsA total of 1095 normal AFV derived from four studies that measured AFV using dye‐dilution or direct measurement at the time of hysterotomy were used to construct reference intervals using polynomial regression, quantile regression, Royston and Wright mean and SD, and Cole's lambda mu sigma (LMS) methods. The 2.5th, 5th, 50th, 95th, and 97.5th centiles were derived for each statistical method.ResultsAFV increased curvilinearly from 15 gestational weeks and onward. Based on the 50th centile, the maximum value occurred at 30 weeks’ gestation for the polynomial regression and mean and SD methods while the maximum was achieved at week 31 for the quantile regression and LMS methods. When data were sparse, the quantile regression method produced dramatically different estimates at the higher centile.ConclusionThe four statistical methods produced similar results at gestational ages in which AFV was high. The quantile regression approach, however, produces results that are more reflective of the data when the data are sparse. Given the flexibility and robustness of the quantile regression method, we recommend its use in constructing reference intervals when the interest lies in the tails of the reference distribution.
Steatosis caused by experimental periodontitis is reversible after removal of ligature in rats
Authors: dos Santos Carvalho J. , Cardoso Guimarães Vasconcelos A. C. , Herlany Pereira Alves E. , dos Santos Carvalho A. , da Silva F. R. P. , de Carvalho França L. F. , de Pádua Rocha Nóbrega Neto A. , Di Lenardo D. , de Souza L. K. M. , Barbosa A. L. dos R. , Medeiros J.‐V. R. , de Oliveira J. S. , Vasconcelos D. F. P. 
Published: May 2017

Background and ObjectivePeriodontitis may promote harmful systemic effects such as changes in hepatic tissues. The purpose of this study was to investigate whether the steatosis and oxidative stress caused by experimental periodontitis are reversible in the liver.Material and MethodsTwenty‐four rats were divided into three groups: control, periodontitis and P20‐20 (20 days with experimental periodontitis and 20 days without experimental periodontitis, to verify the reversibility of hepatic injuries). The following parameters were assessed: gingival bleeding index, probing pocket depth, myeloperoxidase activity, alveolar bone loss for periodontal tissues; liver weights, histopathological scores for steatosis, inflammation and necrosis in liver; glutathione, malondialdehyde, total cholesterol and triglyceride concentrations in hepatic tissues; and blood levels of aspartate aminotransferase, alanine aminotransferase, albumin, gamma‐glutaryl transferase, total cholesterol and random glucose.ResultsGingival bleeding index, probing pocket depth, myeloperoxidase and alveolar bone loss parameters demonstrated the development of periodontitis. There was a significant reduction in the steatosis score of animals from the P20‐20 group when compared with the periodontitis group. P20‐20 group presented significantly higher glutathione (11 times) and lower malondialdehyde (nearly 23%), total cholesterol (both in blood and hepatic tissue) and triglyceride concentrations compared with the periodontitis group. For levels of aspartate aminotransferase, alanine aminotransferase, albumin, gamma‐glutaryl transferase and random glucose, a significant difference between the groups was not observed.ConclusionOur results demonstrate that the microvesicular steatosis caused by periodontitis in rats is reversible after removal of the ligature, which is associated with the increase in oxidative stress and lipid peroxidation in the liver.
The risk of early occurrence and recurrence of hepatocellular carcinoma in hepatitis C‐infected patients treated with direct‐acting antivirals with and without pegylated interferon: A Belgian experience
Authors: Bielen R. , Moreno C. , Van Vlierberghe H. , Bourgeois S. , Mulkay J.‐P. , Vanwolleghem T. , Verlinden W. , Brixco C. , Decaestecker J. , de Galocsy C. , Janssens F. , Van Overbeke L. , Van Steenkiste C. , D'Heygere F. , Cool M. , Wuyckens K. , Nevens F. , Robaeys G. 
Published: May 2017

SummaryRecently, concerns were raised of high rates of HCC recurrence in patients treated with direct‐acting antivirals (DAA) for hepatitis C infection. We investigated the HCC occurrence and recurrence rates within 6 months after treatment with DAA with or without pegylated interferon (PEG‐IFN) in real life. This is a retrospective, multicenter cohort trial, executed in 15 hospitals distributed across Belgium. Populations were matched based on fibrosis score (Metavir F3‐F4). Patients with a Child‐Pugh score ≥ B were excluded. In total, 567 patients were included, of whom 77 were treated with PEG‐IFN+DAA between 2008 and 2013 and 490 with DAA without PEG‐IFN between 2013 and 2015. Patients treated with PEG‐IFN+DAA (53±9y) were younger than patients treated with DAA without PEG‐IFN (59±12y) (P=.001). 47% of patients treated with PEG‐IFN+DAA were in the F4 stage vs 67% of patients treated with DAA without PEG‐IFN (P=.001). Screening was inadequate in 20% of both patient groups (P=.664). The early occurrence rate of HCC was 1.7% and 1.1% in patients treated with DAA with and without PEG‐IFN, respectively (P=.540). The early recurrence rate was 0% in patients treated with PEG‐IFN+DAA and 15.0% in patients treated with DAA without PEG‐IFN (P=.857). There is no difference in early occurrence of new HCC between patients treated with DAA with and without PEG‐IFN. We did observe a high early recurrence rate of HCC in patients treated with DAA without PEG‐IFN. However, these patients were at baseline more at risk for HCC. Finally, in 20%, screening for HCC was inadequate.
Disposition of levetiracetam in healthy adult horses
Authors: Cesar F. B. , Stewart A. J. , Boothe D. M. , Ravis W. R. , Duran S. H. , Wooldridge A. A. 
Published: May 2017

Nine horses received 20 mg/kg of intravenous (LEVIV); 30 mg/kg of intragastric, crushed immediate release (LEVCIR); and 30 mg/kg of intragastric, crushed extended release (LEVCER) levetiracetam, in a three‐way randomized crossover design. Crushed tablets were dissolved in water and administered by nasogastric tube. Serum samples were collected over 48 hr, and levetiracetam concentrations were determined by immunoassay. Mean ± SD peak concentrations for LEVCIR and LEVCER were 50.72 ± 10.60 and 53.58 ± 15.94 μg/ml, respectively. The y‐intercept for IV administration was 64.54 ± 24.99 μg/ml. The terminal half‐life was 6.38 ± 1.97, 7.07 ± 1.93 and 6.22 ± 1.35 hr for LEVCIR, LEVCER, and LEVIV, respectively. Volume of distribution at steady‐state was 630 ± 73.4 ml/kg. Total body clearance after IV administration was 74.40 ± 19.20 ml kg−1 hr−1. Bioavailability was 96 ± 10, and 98 ± 13% for LEVCIR and LEVCER, respectively. A single dose of Levetiracetam (LEV) was well tolerated. Based on this study, a recommended dosing regimen of intravenous or oral LEV of 32 mg/kg every 12 hr is likely to achieve and maintain plasma concentrations within the therapeutic range suggested for humans, with optimal kinetics throughout the dosing interval in healthy adult horses. Repeated dosing and pharmacodynamic studies are warranted.