bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prophylactic heparin in acute intracerebral hemorrhage: a propensity score-matched analysis of the INTERACT2 study
Authors: Muñoz-Venturelli Paula , Wang Xia , Lavados Pablo M , Stapf Christian , Robinson Thompson , Lindley Richard , Heeley Emma , Delcourt Candice , Chalmers John , Anderson Craig S ,   on behalf of the INTERACT2 Investigators
Published: March 2016

Background Indication and timing of pharmacological venous thromboembolism prophylaxis in intracerebral hemorrhage patients is controversial. Aims To determine whether use of subcutaneous heparin during the first 7 days after spontaneous intracerebral hemorrhage increases risks of death and disability. Methods Data are from the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2) study. Patients with acute intracerebral hemorrhage (<6 hours) and elevated systolic blood pressure were included; patients received subcutaneous heparin following local best practice standards of care. Multivariable logistic regression and propensity score matched analysis were used to determine associations of heparin use on death and disability (modified Rankin scale) at 90 days. Results In 2525 patients with available data, there were 465 (22.5%) who received subcutaneous heparin. They had higher death or major disability at 90 days in crude (odds ratio 2.29, 95% confidence interval 1.85–2.84; p < 0.001), adjusted (odds ratio 1.62, 95% confidence interval 1.26–2.09; p < 0.001) and propensity score matched (odds ratio 2.06, 95% confidence interval 1.53–2.77; p < 0.001) analyses. In propensity score matched analysis, heparin-treated patients had significant lower mortality (odds ratio 0.55, 95% CI 0.35–0.87; p = 0.01) but greater major disability (odds ratio 1.68, 95% confidence interval 1.25–2.28; p < 0.001) at 90 days. However, no mortality difference was found in analysis restricted to 48-hour survivors. Conclusions Use of subcutaneous heparin is associated with poor outcome in acute intracerebral hemorrhage, driven by increased residual disability. Despite the limitations of this study, and no clear relation of heparin with bleeding risk, we recommend careful consideration of the need for venous thromboembolism prophylaxis with heparin in intracerebral hemorrhage patients. Trial registration http://www.clinicaltrials.gov NCT00716079.
Psychological Factors Associated With Anterior Cruciate Ligament Reconstruction Recovery
Authors: Christino Melissa A. , Fleming Braden C. , Machan Jason T. , Shalvoy Robert M. 
Published: March 2016

Background: Psychological factors may have underappreciated effects on surgical outcomes after anterior cruciate ligament (ACL) reconstruction; however, few studies have investigated the relationship between specific psychological factors, objective clinical data, and patient-oriented outcomes. Purpose: Psychological factors are significantly associated with patient perceptions and functional outcomes after ACL reconstruction. The purpose of this study was to demonstrate relationships between self-esteem, health locus of control, and psychological distress with objective clinical outcomes, patient-oriented outcomes, and return to sport. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Twenty-seven patients who were 6 to 24 months post–computer-assisted ACL reconstruction by a single surgeon consented to participate in the study (52% response rate). Participants had a 1-time visit with a physician consisting of: a physical examination, a single-leg hop test, KT-1000 arthrometer measurements, and survey completion. Psychological measures included the Multidimensional Health Locus of Control Scale, Rosenberg Self-Esteem Scale, and Brief Profile of Mood States. Outcome measures included the Tegner activity scale, International Knee Documentation Committee (IKDC) Subjective Knee Score, Knee injury and Osteoarthritis Outcome Score–Quality of Life subscale (KOOS-QOL), and Short Form–36 (SF-36). Patient charts were also reviewed for pertinent operative details. Results: The mean age of patients (±SD) was 25.7 ± 8.4 years, and the mean duration of time since surgery was 16.5 ± 5.9 months. The majority (89%) of the patients identified themselves as athletes, and of these, 65% reported returning to sports at a competitive level. Sport returners were found to have higher levels of self-esteem ( P = .002) and higher reported KOOS-QOL scores ( P = .02). Self-esteem was significantly associated with IKDC scores ( r = 0.46, P < .05), KOOS-QOL scores ( r = 0.45, P < .05), and SF-36 subscales of general health ( r = 0.45, P < .05) and physical functioning ( r = 0.42, P < .05). Internal locus of control was significantly correlated with performance on single-leg hop test ( r = 0.4, P < .05). Objective knee stability measurements did not correlate with subjective outcomes. Conclusion: Self-esteem levels and locus of control had significant relationships with functional test performance and validated outcome measures after ACL reconstruction. Sport returners had significantly higher self-esteem levels than those who did not return to sports, without observable differences in knee stability or time since surgery.
Decitabine enhances anti-CD33 monoclonal antibody BI 836858–mediated natural killer ADCC against AML blasts
Authors: Vasu Sumithira , He Shun , Cheney Carolyn , Gopalakrishnan Bhavani , Mani Rajeswaran , Lozanski Gerard , Mo Xiaokui , Groh Veronica , Whitman Susan P. , Konopitzky Renate , Kössl Christian , Bucci Donna , Lucas David M. , Yu Jianhua , Caligiuri Michael A. , Blum William , Adam Paul J. , Borges Eric , Rueter Bjoern , Heider Karl-Heinz , Marcucci Guido , Muthusamy Natarajan 
Published: March 2016

Key Points
BI 836858, an Fc-engineered anti-CD33 antibody, mediates autologous and allogeneic NK cell–mediated ADCC. Decitabine increases ligands for activating NK receptors potentiating BI 836858 activity, providing a rationale for combination therapy.
Lung exposure to lipopolysaccharide causes atherosclerotic plaque destabilisation
Authors: Jaw Jen Erh , Tsuruta Masashi , Oh Yeni , Schipilow John , Hirano Yuki , Ngan David A. , Suda Koichi , Li Yuexin , Oh Jin Young , Moritani Konosuke , Tam Sheena , Ford Nancy , van Eeden Stephan , Wright Joanne L. , Man S.F. Paul , Sin Don D. 
Published: March 2016

Epidemiological studies have implicated lung inflammation as a risk factor for acute cardiovascular events, but the underlying mechanisms linking lung injury with cardiovascular events are largely unknown.Our objective was to develop a novel murine model of acute atheromatous plaque rupture related to lung inflammation and to investigate the role of neutrophils in this process.Lipopolysaccharide (LPS; 3 mg·kg−1) or saline (control) was instilled directly into the lungs of male apolipoprotein E-null C57BL/6J mice following 8 weeks of a Western-type diet. 24 h later, atheromas in the right brachiocephalic trunk were assessed for stabilityex vivousing high-resolution optical projection tomography and histology. 68% of LPS-exposed mice developed vulnerable plaques, characterised by intraplaque haemorrhage and thrombus,versus12% of saline-exposed mice (p=0.0004). Plaque instability was detectable as early as 8 h post-intratracheal LPS instillation, but not with intraperitoneal instillation. Depletion of circulating neutrophils attenuated plaque rupture.We have established a novel plaque rupture model related to lung injury induced by intratracheal exposure to LPS. In this model, neutrophils play an important role in both lung inflammation and plaque rupture. This model could be useful for screening therapeutic targets to prevent acute vascular events related to lung inflammation.
Vascular effects of sildenafil in patients with pulmonary fibrosis and pulmonary hypertension: anex vivo/in vitrostudy
Authors: Milara Javier , Escrivá Juan , Ortiz José Luis , Juan Gustavo , Artigues Enrique , Morcillo Esteban , Cortijo Julio 
Published: March 2016

Sildenafil improves the 6-min walking distance in patients with idiopathic pulmonary fibrosis (IPF) and right-sided ventricular systolic dysfunction.We analysed the previously unexplored role of sildenafil on vasoconstriction and remodelling of pulmonary arteries from patients with IPF and pulmonary hypertension (PH)ex vivo. Pulmonary arteries from 18 donors without lung disease, nine IPF, eight PH+IPF and four PH patients were isolated to measure vasodilator and anti-contractile effects of sildenafil in isometric organ bath. Ventilation/perfusion was explored in an animal model of bleomycin lung fibrosis.Sildenafil relaxed serotonin (5-HT) pre-contracted pulmonary arteries in healthy donors and IPF patients and, to a lesser extent, in PH+IPF and PH. Sildenafil inhibited 5-HT dose-response contraction curve mainly in PH+IPF and PH, but not in healthy donors. Sildenafil did not impair the ventilation/perfusion mismatching induced by bleomycin. Pulmonary arteries from PH+IPF patients showed a marked expression of phosphodiesterse-5 and extracellular matrix components. Sildenafil inhibited pulmonary artery endothelial and smooth muscle cell to mesenchymal transition by inhibition of extracellular regulated kinases 1 and 2 (ERK1/2) and SMAD3 phosphorylation.These results suggest an absence of direct relaxant effect and a prominent anti-contractile and anti-remodelling role of sildenafil in PH+IPF pulmonary arteries that could explain the beneficial effects of sildenafil in IPF with PH phenotype.
C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress
Authors: Hirani Nisha , Westenberg Marcel , Seed Paul T. , Petalcorin Mark I. R. , Dolphin Colin T. 
Published: March 2016

ABSTRACT
Studies in Caenorhabditiselegans have revealed osmoregulatory systems engaged when worms experience hypertonic conditions, but less is known about measures employed when faced with hypotonic stress. Inactivation of fmo-4, which encodes flavin-containing monooxygenase-4, results in dramatic hypoosmotic hypersensitivity; worms are unable to prevent overwhelming water influx and swell rapidly, finally rupturing due to high internal hydrostatic pressure. fmo-4 is expressed prominently in hypodermis, duct and pore cells but is excluded from the excretory cell. Thus, FMO-4 plays a crucial osmoregulatory role by promoting clearance of excess water that enters during hypotonicity, perhaps by synthesizing an osmolyte that acts to establish an osmotic gradient from excretory cell to duct and pore cells. C. elegans FMO-4 contains a C-terminal extension conserved in all nematode FMO-4s. The coincidently numbered human FMO4 also contains an extended C-terminus with features similar to those of FMO-4. Although these shared sequence characteristics suggest potential orthology, human FMO4 was unable to rescue the fmo-4 osmoregulatory defect. Intriguingly, however, mammalian FMO4 is expressed predominantly in the kidney – an appropriate site if it too is, or once was, involved in osmoregulation.
A protocol to examine vision and gait in Parkinson’s disease: impact of cognition and response to visual cues
Authors: Stuart Samuel , Galna Brook , Lord Sue , Rochester Lynn 
Published: March 2016

BackgroundCognitive and visual impairments are common in Parkinson’s disease (PD) and contribute to gait deficit and falls. To date, cognition and vision in gait in PD have been assessed separately. Impact of both functions (which we term ‘visuo-cognition’) on gait however is likely interactive and can be tested using visual sampling (specifically saccadic eye movements) to provide an online behavioural measure of performance. Although experiments using static paradigms show saccadic impairment in PD, few studies have quantified visual sampling during dynamic motor tasks such as gait.This article describes a protocol developed for testing visuo-cognition during gait in order to examine the: 1) independent roles of cognition and vision in gait in PD, 2) interaction between both functions, and 3) role of visuo-cognition in gait in PD.Methods Two groups of older adults (≥50 years old) were recruited; non-demented people with PD (n=60) and age-matched controls (n=40). Participants attended one session and a sub-group (n=25) attended two further sessions in order to establish mobile eye-tracker reliability. Participants walked in a gait laboratory under different attentional (single and dual task), environmental (walk straight, through a door and turning), and cueing (no visual cues and visual cues) conditions. Visual sampling was recorded using synchronised mobile eye-tracker and electrooculography systems, and gait was measured using 3D motion analysis.Discussion This exploratory study examined visuo-cognitive processes and their impact on gait in PD. Improved understanding of the influence of cognitive and visual functions on visual sampling during gait and gait in PD will assist in development of interventions to improve gait and reduce falls risk. This study will also help establish robust mobile eye-tracking methods in older adults and people with PD.
Dissecting the Dissection
Authors: Sherif Hisham M.F. 
Published: March 2016

AbstractAortic dissection remains one of the most devastating diseases. Current practice guidelines provide diagnostic and therapeutic interventions based primarily on the aortic diameter. The level of evidence supporting these recommendations is Level C or “Expert Opinion” Since aortic dissection is a catastrophic structural failure, its investigation along the guidelines of accident investigation may offer a useful alternative, utilizing process mapping and root-cause analysis methodology. Since the objective of practice guidelines is to address the risk of serious events, on the utilization of a probabilistic predictive modeling methodology, using bioinformatics tools, may offer a more comprehensive risk assessment.
Flex-it: Exploring emotional expression through elasticity in digital manufacturing
Authors: Dean Lionel T. , Niedderer Kristina 
Published: March 2016

Abstract
This research investigates the potential of structural flexibility as a functional and affective design element as well as its potential applications. Our research bridges the areas of jewellery design, emotion design and structural development in the Additive Manufacture (AM) of metals. The article offers a theoretical review of the nature of flexible structures and of current deformable AM geometries and their applications. In relation to this, we conducted a series of practical experiments, which explored AM flexible geometries to create emotional expression. Both, existing examples and the outcomes of the experiments were evaluated against the soma-semiotic framework of emotional expression developed by Niedderer. The outcome and contribution of the research is a better understanding of structural geometries of flexibility and their potential uses, as well as of its affective potential.
Ambiguous luminosity
Authors: Zimmer Jeff 
Published: March 2016

Abstract
This article is an autobiographical review by Jeff Zimmer discussing his multi-layered illuminated paintings on glass and how the theme of ambiguity threads through his work. Aesthetic and conceptual developments over the past decade are traced in this article, including research on mythological models of ambiguity, connections between seeing and judging reflected in security camera images, the use of the concept of averted vision in the expression of thematic content, the symbolic use of snow as a metaphor for ‘whitewashing’, and the use of drones to communicate disconnects between action and consequence. His aesthetic development is traced from flat figurative images to multi-layered, three-dimensional (3D) de-populated landscapes.
A Design Approach to Innovation in the Australian Energy Industry
Authors: Stevenson Tim , Wrigley Cara , Matthews Judy 
Published: March 2016

Abstract
Electricity distribution businesses across Australia are facing many market disruptions, such as the increasing demand from the rapid uptake of domestic air conditioners and the contrasting problematic generation from solar power connections to the grid. In this context, the opportunity to proactively leverage forthcoming technological advances in battery storage and electric vehicles to address the steeply rising cost of electricity supply has emerged. This research explores a design approach to support a business to navigate such disruptions in the current market.
This study examines a design-led approach to innovation conducted over a tenmonth action research study within a large, risk-averse firm in the Australian energy sector. This article presents results describing a current foresight gap within the business; the response of the business to using design-led innovation to address this issue; and the tools, approaches and processes used. The business responses indicate their perception of the value of qualitative customer engagement as a path to addressing, and potentially benefiting from, disruptive innovation. It is anticipated that these results will further business model development within the company, and assist in leveraging disruptive innovations for this industry participant, thus limiting future increases in the cost of electricity supply for customers in Australia.
The Value and Importance of Design When Branding for Social Media: Models for a Framework Analysis
Authors: Gancho Sara , Cooper Rachel , Evans Martyn 
Published: March 2016

Abstract
This article presents an investigation into understanding the role of design and designers when managing creative brand strategies for social media, and was conducted in Portugal and the United Kingdom during 2011–12. It combines results from an online survey (103 participants) and interviews (21 interviews) regarding the role of design in branding for social media. Based on the results, two models were elaborated; these models allow the integration of a social media strategy by adding to the existing design ladder model. Model validation was achieved by an online survey (30 responses) completed by a panel of experts.
Three different research domains were considered for this study: namely branding, design and social media. With regard to branding, we opted to focus on the branding literature that is concerned with strategic brand management, as well as social marketing management literature. Concerning design, we focused on its importance to both branding and social media, while also addressing the importance of design management in branding today and how it is connected to new research in social media. An analysis of how social media has developed into a growing and important platform for brands to connect with consumers (and vice versa) was also conducted. In addition, we analysed how social media generates business and return on investment. The article connects aspects of branding and design that are crucial to the social media field. Our goal is to clarify the importance and impact of design management in social media strategy, branding and business.
Exploring pop-up cinema and the city: Deleuzian encounters with secret cinema’s pop-up screening of The Third Man
Authors: Harris Ella 
Published: March 2016

Abstract
In this article I mobilize Deleuze to explore transformative relationships between filmic and urban space in Secret Cinema’s pop-up screening of Carol Reed’s The Third Man (1949). Secret Cinema is a company that turns urban sites into dramatized versions of the films they screen, and this unusual practice of exhibition raises fascinating questions about how film texts and urban sites come into contact. In particular, I respond to two crucial questions that are provoked by Secret Cinema’s ‘immersive’ screening of The Third Man. First, I consider the impact this kind of filmic experience has on ways of seeing the urban, drawing on the Deleuzian concept of the any-space-whatever. Second, I take up Deleuze’s ideas about the out-of-field and its differing functions within the movement-image and the time-image to address how Secret Cinema’s dramatized site of spectatorship reciprocally transforms the meaning of film text and urban space. By addressing these two questions, and with comparative reference to early cinema’s practices of exhibition, I develop a nuanced reading of Secret Cinema’s screening as a co-production of filmic and urban space.
Of other worlds: A dialogue on the disappearing gardens of Fez and the different worlds they foster
Authors: Vogels Heidi , Kuipers Halbe Hessel 
Published: March 2016

Abstract
This article presents a dialogue on the disappearing gardens of Fez and the garden as a concept as they both relate to a film in the making: GARDENSOFFEZ. We approach the garden as an ‘other space’, one that fosters different worlds, and wonder how these can relate. Our thinking passes through the philosophy of Gilles Deleuze, allowing us to move from spaces to worlds in affective terms, to Michel Foucault’s concept of the heterotopia, where worlds can come together, slip into one another, to create new worlds. By, on the one side, looking at the actual situation of Rajae, the main character in the film, interacting with the gardens, and on the other side the virtual gardens of Jorge Luis Borges, we seek for how these newly emerging worlds can be seen as comprehensively material, being both actual and virtual at the same time.
Paris vs providence: Framing the crystalline city in Jean Renoir’s La Chienne (1931)
Authors: Nevin Barry 
Published: March 2016

Abstract
In Cinéma 2: l’image-temps (1985), Gilles Deleuze remarks that Jean Renoir’s pioneering use of deep space makes manifest a cracked crystal of time that structures the director’s oeuvre. Deleuze states that within Renoir’s crystal, characters constantly negotiate a tension between the ‘dead roles’ of the past and the possibility for the creation of a genuinely new future. Deleuze’s analysis, although insightful, suggests that Renoir’s mise-en-scène articulates the cracked crystal’s temporal properties regardless of the narrative setting. Drawing on Renoir’s photography of Paris in La Chienne (1931), this article demonstrates the import of setting, specifically urban topography, towards Renoir’s dialectic of imprisonment and escape. In La Chienne, formal tensions between Renoir’s mise-en-scène of the theatre and Paris foreground the city’s role as an active catalyst of the characters’ individual trajectories in a world where social identity remains crucially unfixed. Central to this analysis is the motif of the frame, which is appropriated in conjunction with deep space and off-screen space in the city in order to emphasize the impossibility of confining urban narrative to the rigid confines of the proscenium arches that bookend the protagonist’s drama. This article ultimately argues that Renoir’s crystalline image is not only the product of camera techniques and characterization, but also of the mutually affective relationship between urban physical and social space.