bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comprehensive color solutions: CAM16, CAT16, and CAM16‐UCS
Authors: Li Changjun , Li Zhiqiang , Wang Zhifeng , Xu Yang , Luo Ming Ronnier , Cui Guihua , Melgosa Manuel , Brill Michael H. , Pointer Michael 
Published: June 2017

AbstractThe CIECAM02 color‐appearance model enjoys popularity in scientific research and industrial applications since it was recommended by the CIE in 2002. However, it has been found that computational failures can occur in certain cases such as during the image processing of cross‐media color reproduction applications. Some proposals have been developed to repair the CIECAM02 model. However, all the proposals developed have the same structure as the original CIECAM02 model and solve the problems concerned at the expense of losing accuracy of predicted visual data compared with the original model. In this article, the structure of the CIECAM02 model is changed and the color and luminance adaptations to the illuminant are completed in the same space rather than in two different spaces, as in the original CIECAM02 model. It has been found that the new model (named CAM16) not only overcomes the previous problems, but also the performance in predicting the visual results is as good as if not better than that of the original CIECAM02 model. Furthermore the new CAM16 model is simpler than the original CIECAM02 model. In addition, if considering only chromatic adaptation, a new transformation, CAT16, is proposed to replace the previous CAT02 transformation. Finally, the new CAM16‐UCS uniform color space is proposed to replace the previous CAM02‐UCS space. A new complete solution for color‐appearance prediction and color‐difference evaluation can now be offered.
Breast cancer cell obatoclax response characterization using passivated‐electrode insulator‐based dielectrophoresis
Authors: Soltanian‐Zadeh Sepeedah , Kikkeri Kruthika , Shajahan‐Haq Ayesha N. , Strobl Jeannine , Clarke Robert , Agah Masoud 
Published: June 2017

Inherent electrical properties of cells can be beneficial to characterize different cell lines and their response to experimental drugs. This paper presents a novel method to characterize the response of breast cancer cells to drug stimuli through use of off‐chip passivated‐electrode insulator‐based dielectrophoresis (OπDEP) and the application of AC electric fields. This work is the first to demonstrate the ability of OπDEP to differentiate between two closely related breast cancer cell lines, LCC1 and LCC9 while assessing their drug sensitivity to an experimental anti‐cancer agent, Obatoclax. Although both cell lines are derivatives of estrogen‐responsive MCF‐7 breast cancer cells, growth of LCC1 is estrogen independent and anti‐estrogen responsive, while LCC9 is both estrogen‐independent and anti‐estrogen resistant. Under the same operating conditions, LCC1 and LCC9 had different DEP profiles. LCC1 cells had a trapping onset (crossover) frequency of 700 kHz and trapping efficiencies between 30–40%, while LCC9 cells had a lower crossover frequency (100 kHz) and showed higher trapping efficiencies of 40–60%. When exposed to the Obatoclax, both cell lines exhibited dose‐dependent shifts in DEP crossover frequency and trapping efficiency. Here, DEP results supplemented with cell morphology and proliferation assays help us to understand the response of these breast cancer cells to Obatoclax.
Field evidence for the control of grain size and sediment supply on steady‐state bedrock river channel slopes in a tectonically active setting
Authors: Finnegan Noah J. , Klier Rachael A. , Johnstone Samuel , Pfeiffer Allison M. , Johnson Kerri 
Published: June 2017

AbstractWe exploit a natural experiment in Boulder Creek, a ~ 30 km2 drainage in the Santa Cruz mountains, CA, USA to explore how an abrupt increase in the caliber of bedload sediment along a bedrock channel influences channel morphology in an actively uplifting landscape. Boulder Creek's bedrock channel, which is entirely developed on weak sedimentary rock, has a high flow shear stress that is about 3.5 times greater where it transports coarse (~ 22 cm D50) diorite in the lower reaches in comparison with the upstream section of the creek that transports only relatively finer bedload (~2 cm D50) derived from weak sedimentary rocks. In addition, Boulder Creek's channel abruptly widens and shallows downstream and transitions from partial to nearly continuous alluvial cover where it begins transporting coarse diorite. Boulder Creek's tributary channels are also about three times steeper where they transport diorite bedload, and within the Santa Cruz mountains channels in sedimentary bedrock are systematically steeper when >50% of their catchment area is within crystalline basement rocks. Despite this clear control of coarse sediment size on channel slopes, the threshold of motion stress for bedload, alone, does not appear to control channel profile slopes here. Upper Boulder Creek, which is starved of coarse sediment, maintains high flow shear stresses well in excess of the threshold for motion. In contrast, lower Boulder Creek, with a greater coarse sediment supply, exerts high flow stresses much closer to the threshold for motion. We speculate that upper Boulder Creek has evolved to sustain partial alluvial cover and transfer greater energy to the bed via bedload impacts to compensate for its low coarse sediment supply. Thus bedload supply, bedrock erosion efficiency, and grain size all appear to influence channel slopes here. Copyright © 2017 John Wiley & Sons, Ltd.
Conceptual Indicators Framework for Strengthening the Chinese Health System
Authors: Xiao Yue , Zhao Kun , Sridharan Sanjeev , Cao Xiaohong 
Published: June 2017

AbstractIn 2009 the national government of China launched massive health reforms, together with other social and economic reforms. For the first time, evaluation was included in the draft national plan of health reforms and development—the so‐called “12th Five‐Year National Plan for Health Development (2011–2015).” The Chinese and Canadian researchers, with the support of the International Development Research Centre, Canada, helped to facilitate a deliberative process by various actors by conceptualizing an indicators system and mapping out key questions to be addressed by evaluating implementation of the national health plan. The conceptual indicators system serves as a platform for users and implementers of evaluation program to understand needs for evaluation better and sharpen focus on more prominent dimensions such as equity and contextual analysis.
Toward a Structured Process to Evaluate Health Inequities: Lessons Learned from Developing and Implementing Evaluation Guidelines to Address Health Inequities
Authors: Sridharan Sanjeev , Zhao Kun , Nakaima April , Maplazi Joanna , Yu Mo , Qiu Yingpeng 
Published: June 2017

AbstractThis paper discusses the development and implementation of structured guidelines that contained a fixed set of questions as part of a project in building evaluation capacity for addressing health inequities in the health sector in China. The ambition of the guidelines was to test whether a structured process of questions could aid teams that did not have a strong background in evaluation to complete equity‐focused evaluations and also help raise the salience of health equity as an important goal of health systems reform among the participants of the project. The guidelines were informed by multiple perspectives that included the literature on social determinants of health, realist evaluation, and utilization/influence perspectives. One noteworthy aspect of this project was that the participants in this capacity‐building project were local and national policymakers, practitioners, and university researchers. Our original goal was to test these guidelines in equity‐focused policy interventions in three separate provinces of China. One key insight from this project was that there is a need to move away from a testing perspective to a developmental approach in formulating evaluation guidelines that can work across multiple organizational and country contexts and also closely reflect the needs of practitioners and policymakers in evaluation capacity‐building efforts.
Lessons Learned from Evaluating China's New Cooperative Medical Scheme
Authors: Yu Mo , He Xiaoyan , Hou Yunxin , Li Xue 
Published: June 2017

AbstractChina's New Cooperative Medical Scheme (NCMS), established in 2003, is a universal health care insurance program for rural residents aimed to improve access to basic health care services and reduce financial risks of catastrophic illnesses in the rural population. It is a cornerstone of China's most recent health care reform efforts. The purpose of this paper is to share insights and learnings from two evaluations of NCMS payment reform. The evaluations were conducted by local researchers and evaluators who were deeply involved in the design and implementation of NCMS in their own region and have gone through a process of reflection of their own work to bring learnings to the broader health systems and evaluation communities in China.
Importance of DOTA derivatives in bimodal imaging
Authors: Chilla Satya Narayana Murthy , Henoumont Céline , Elst Luce Vander , Muller Robert N. , Laurent Sophie 
Published: June 2017

AbstractThe clinical applications of multimodal probes are numerous since a few decades. 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA) has played an important role in diagnostic and therapeutic areas. The vast applications of DOTA as chelator have been explored in magnetic resonance imaging (MRI) and in radioisotope chemistry. Moreover, the possibility to functionalize the macrocycle with pendant arms has allowed to explore new functionalities as bimodal imaging agents. Different combinations are possible between the different possible imaging techniques like Magnetic Resonance Imaging, Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Optical imaging (OI). The main use of DOTA and its derivatives was for MRI as gadolinium complexes. It was then further extended to the complexation with europium or terbium for optical imaging. Although other chelates are available such as DTPA or NOTA, derivatives of DOTA were often the primary choice due to their versatility. DOTA derivatives can indeed also be complexed with radioisotopes and conjugated to peptides which leads to targeted contrast agents for PET or SPECT. Depending on the chosen imaging modality, a variety of radiometals can be complexed with DOTA, e.i. 64Cu and 68Ga for PET, or 111In and 90Y for SPECT. Conjugation of chromophores to gadolinium complexes of DOTA derivatives can also lead to bimodal agents for MRI and OI. In this review, we will provide the applications of DOTA and its derivatives in different imaging modalities and their clinical applications.
Bone Mass Is Compromised by the Chemotherapeutic Trabectedin in Association With Effects on Osteoblasts and Macrophage Efferocytosis
Authors: Sinder Benjamin P , Zweifler Laura , Koh Amy J , Michalski Megan N , Hofbauer Lorenz C , Aguirre Jose Ignacio , Roca Hernan , McCauley Laurie K 
Published: June 2017

ABSTRACT

Macrophages have established roles supporting bone formation. Despite their professional phagocytic nature, the role of macrophage phagocytosis in bone homeostasis is not well understood. Interestingly, apoptosis is a pivotal feature of cellular regulation and the primary fate of osteoblasts is apoptosis. Efferocytosis (phagocytosis of apoptotic cells) is a key physiologic process for the homeostasis of many tissues, and is associated with expression of osteoinductive factors. To test effects of macrophage depletion and compromised phagocytosis on bone, 16-week-old male C57BL/6J mice were treated with trabectedin—a chemotherapeutic with established anti-macrophage effects. Trabectedin treatment reduced F4/80+ and CD68+ macrophages in the bone marrow as assessed by flow cytometry, osteal macrophages near the bone surface, and macrophage viability in vitro. Trabectedin treatment significantly reduced marrow gene expression of key phagocytic factors (Mfge8, Mrc1), and macrophages from treated mice had a reduced ability to phagocytose apoptotic mimicry beads. Macrophages cultured in vitro and treated with trabectedin displayed reduced efferocytosis of apoptotic osteoblasts. Moreover, efferocytosis increased macrophage osteoinductive TGF-β production and this increase was inhibited by trabectedin. Long-term (6-week) treatment of 16-week-old C57BL/6J mice with trabectedin significantly reduced trabecular BV/TV and cortical BMD. Although trabectedin reduced osteoclast numbers in vitro, osteoclast surface in vivo was not altered. Trabectedin treatment reduced serum P1NP as well as MS/BS and BFR/BS, and inhibited mineralization and Runx2 gene expression of osteoblast cultures. Finally, intermittent PTH 1-34 (iPTH) treatment was administered in combination with trabectedin, and iPTH increased trabecular bone volume fraction (BV/TV) in trabectedin-treated mice. Collectively, the data support a model whereby trabectedin significantly reduces bone mass due to compromised macrophages and efferocytosis, but also due to direct effects on osteoblasts. This data has immediate clinical relevance in light of increasing use of trabectedin in oncology. © 2017 American Society for Bone and Mineral Research.
Therapeutic Effects of FGF23 c-tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption
Authors: Johnson Kristen , Levine Kymberly , Sergi Joseph , Chamoun Jean , Roach Rachel , Vekich Jacqueline , Favis Mike , Horn Mark , Cao Xianjun , Miller Brian , Snyder William , Aivazian Dikran , Reagan William , Berryman Edwin , Colangelo Jennifer , Markiewicz Victoria , Bagi Cedo M , Brown Thomas P , Coyle Anthony , Mohammadi Moosa , Magram Jeanne 
Published: June 2017

ABSTRACT

Fibroblast growth factor 23 (FGF23) is the causative factor of X-linked hypophosphatemia (XLH), a genetic disorder effecting 1:20,000 that is characterized by excessive phosphate excretion, elevated FGF23 levels and a rickets/osteomalacia phenotype. FGF23 inhibits phosphate reabsorption and suppresses 1α,25-dihydroxyvitamin D (1,25D) biosynthesis, analytes that differentially contribute to bone integrity and deleterious soft-tissue mineralization. As inhibition of ligand broadly modulates downstream targets, balancing efficacy and unwanted toxicity is difficult when targeting the FGF23 pathway. We demonstrate that a FGF23 c-tail-Fc fusion molecule selectively modulates the phosphate pathway in vivo by competitive antagonism of FGF23 binding to the FGFR/α klotho receptor complex. Repeated injection of FGF23 c-tail Fc in Hyp mice, a preclinical model of XLH, increases cell surface abundance of kidney NaPi transporters, normalizes phosphate excretion, and significantly improves bone architecture in the absence of soft-tissue mineralization. Repeated injection does not modulate either 1,25D or calcium in a physiologically relevant manner in either a wild-type or disease setting. These data suggest that bone integrity can be improved in models of XLH via the exclusive modulation of phosphate. We posit that the selective modulation of the phosphate pathway will increase the window between efficacy and safety risks, allowing increased efficacy to be achieved in the treatment of this chronic disease. © 2017 American Society for Bone and Mineral Research.
The Effects of Twelve Weeks of Tai Chi Practice on Anxiety in Stressed But Healthy People Compared to Exercise and Wait‐List Groups–A Randomized Controlled Trial
Authors: Zheng Shuai , Kim Christine , Lal Sara , Meier Peter , Sibbritt David , Zaslawski Chris 
Published: June 2017

ObjectiveThis randomized controlled trial was undertaken to determine whether 12 weeks of Tai Chi (TC) practice can reduce anxiety in healthy but stressed people.MethodFifty participants were randomized into TC (n=17), exercise (n=17), and wait‐list (WL) groups (n=16). Outcome measures used were State Trait Anxiety Inventory, Perceived Stress Scale 14 (PSS14), blood pressure and heart rate variability, visual analogue scale (VAS), and Short Form 36.ResultsSignificant improvements were observed from baseline for both TC and exercise groups for both state (p <0.01) and trait (p <0.01) anxiety, PSS14 (p <0.01), VAS (p <0.01), mental health domain (p <0.01), and vitality domain (p <0.01). Superior outcomes were also observed for TC when compared with WL for state and trait anxiety (p <0.01) and mental health domain (p <0.05).ConclusionTC reduces stress levels in healthy individuals and provides a safer, cost effective, and less physically vigorous alternative to exercise.
Inhibitory Effect of Low‐Intensity Pulsed Ultrasound on the Expression of Lipopolysaccharide‐Induced Inflammatory Factors in U937 Cells
Authors: Zhang Xuan , Hu Bo , Sun Jicheng , Li Jie , Liu Shan , Song Jinlin 
Published: June 2017

ObjectivesLow‐intensity pulsed ultrasound (US) has been reported to promote periodontal tissue regeneration and reduce inflammation in soft tissues and in bone infectious diseases. Here we investigated the effect of low‐intensity pulsed US on the expression of lipopolysaccharide (LPS)‐induced inflammatory factors in U937 macrophage cells.MethodsU937 cells were stimulated with different concentrations of LPS and exposed to different intensities of low‐intensity pulsed US. Cell viability and apoptosis of U937 cells were determined by cell‐counting kit assays and flow cytometry. A real‐time polymerase chain reaction and an enzyme‐linked immunosorbent assay were used to test the expression of inflammatory factors. The expression levels of toll‐like receptor 4, p65, p‐IκBα, and IκBα were assessed by western blots.ResultsTumor necrosis factor α began to increase in U937 cells on induction with 1‐μg/mL LPS. Low‐intensity pulsed US at the intensity of 60 mW/cm2 was more effective in reducing interleukin 8 (IL‐8) expression. Furthermore, LPS inhibited the viability and increased apoptosis of U937 cells, whereas low‐intensity pulsed US significantly reversed these effects (P < .05). Low‐intensity pulsed US reduced the protein expression of IL‐6 and IL‐8 at both gene and protein levels in U937 cells. The western blot and immunofluorescence showed that low‐intensity pulsed US primarily suppressed the degradation and phosphorylation of IκBα and the translocation of p65 into the nuclei.ConclusionsLow‐intensity pulsed US alleviated the expression of inflammatory factors induced by LPS in U937 cells. This process was modulated by suppressing the toll‐like receptor 4–nuclear factor κB signaling pathway. Therefore, low‐intensity pulsed US might be a potential immunomodulatory therapy for the treatment of periodontitis.
What drives productivity loss in chronic rhinosinusitis? A SNOT‐22 subdomain analysis
Authors: Chowdhury Naweed I. , Mace Jess C. , Smith Timothy L. , Rudmik Luke 
Published: June 2017

Objectives/HypothesisPrevious studies have shown declines in productivity due to chronic rhinosinusitis (CRS) are correlated with disease‐specific quality‐of‐life (QOL) measures. However, it is unclear which symptom domains contribute primarily to productivity loss. This investigation sought to assess the association between CRS‐specific QOL subdomain impairment and productivity loss.Study DesignProspective, multi‐institutional, observational cohort study.MethodsThere were 198 patients with refractory CRS enrolled between August 2012 and June 2015. Baseline QOL measures were obtained across five subdomains of the 22‐item SinoNasal Outcome Test (SNOT‐22). Lost productivity time was determined from patient‐reported measures of annual absenteeism, presenteeism, and lost leisure time, and then monetized using annual daily wage rates from the 2012 US National Census and 2013 Department of Labor statistics.ResultsProductivity losses correlated with impairments in both SNOT‐22 psychological dysfunction (Spearman correlation coefficient [Rs] = 0.428, P < .001), and sleep dysfunction domain scores (Rs = 0.355, P < .001). Higher SNOT‐22 total scores also significantly correlated with increased monetized productivity losses (Rs = 0.366, P < .001). The mean annual productivity cost was $11,820/patient, whereas patients with comorbid immunodeficiency ($23,285/patient), tobacco use ($23,195/patient), and steroid dependency ($18,910/patient) reported higher than average annual productivity costs. Multivariate linear regression found maximum annual productivity costs in adjusted psychological ($13,300/patient, P < .001) and sleep dysfunction ($9,275/patient, P < .001) domains.ConclusionsImpairments in sleep and psychological SNOT‐22 domains correlate with productivity losses. Patients with comorbid immunodeficiency, smoking, and steroid dependency had higher than average productivity losses. Targeted management of psychological and sleep dysfunction in combination with standard symptom control may improve patient‐centered care and reduce the annual economic burden of CRS.Level of Evidence2c. Laryngoscope, 128:23–30, 2018
Whole exome sequencing and DNA methylation analysis in a clinical amyotrophic lateral sclerosis cohort
Authors: Garton Fleur C. , Benyamin Beben , Zhao Qiongyi , Liu Zhijun , Gratten Jacob , Henders Anjali K. , Zhang Zong‐Hong , Edson Janette , Furlong Sarah , Morgan Sarah , Heggie Susan , Thorpe Kathryn , Pfluger Casey , Mather Karen A. , Sachdev Perminder S. , McRae Allan F. , Robinson Matthew R. , Shah Sonia , Visscher Peter M. , Mangelsdorf Marie , Henderson Robert D. , Wray Naomi R. , McCombe Pamela A. 
Published: June 2017

AbstractBackgroundGene discovery has provided remarkable biological insights into amyotrophic lateral sclerosis (ALS). One challenge for clinical application of genetic testing is critical evaluation of the significance of reported variants.MethodsWe use whole exome sequencing (WES) to develop a clinically relevant approach to identify a subset of ALS patients harboring likely pathogenic mutations. In parallel, we assess if DNA methylation can be used to screen for pathogenicity of novel variants since a methylation signature has been shown to associate with the pathogenic C9orf72 expansion, but has not been explored for other ALS mutations. Australian patients identified with ALS‐relevant variants were cross‐checked with population databases and case reports to critically assess whether they were “likely causal,” “uncertain significance,” or “unlikely causal.”ResultsPublished ALS variants were identified in >10% of patients; however, in only 3% of patients (4/120) could these be confidently considered pathogenic (in SOD1 and TARDBP). We found no evidence for a differential DNA methylation signature in these mutation carriers.ConclusionsThe use of WES in a typical ALS clinic demonstrates a critical approach to variant assessment with the capability to combine cohorts to enhance the largely unknown genetic basis of ALS.