bluuebunny/crossref_metadata_2025_split huggingface dataset:
Solitary fibrous tumor of the breast: A case report and review of the literature
Authors: Tsai Shu‐Ya , Hsu Chih‐Yi , Chou Yi‐Hong , Lai Yi‐Chen , Lin Yung‐Hui , Wang Hsin‐Kai , Chiou Hong‐Jen , Wang Jane , Tiu Chui‐Mei 
Published: October 2016

ABSTRACTSolitary fibrous tumor (SFT) is an uncommon neoplasm of mesenchymal origin, which can be benign or malignant. Most SFTs develop from the pleura, but they can also be found in other sites. There are only few reports of SFT occurring in the breast. We herein report such a rare case. Sonography demonstrated an ovoid lesion mimicking a fibroadenoma, whereas color Doppler imaging showed marked internal vascularity. A brief literature review on imaging features of SFTs is added. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:350–354, 2017;
Rape investigation and attrition in acquaintance, domestic violence and historical rape cases
Authors: Hester Marianne , Lilley Sarah‐Jane 
Published: October 2016

AbstractThis paper looks at the progression of rape cases through the criminal justice system, from report to court, exploring the different attrition trajectories for cases that can be characterized as involving acquaintance, intimate domestic violence, and historical child sexual abuse contexts. Using police data from three police forces in England covering 87 cases, interviews relating to 15 victim/survivors and interviews with criminal justice professional, the paper explores investigative processes and victim engagement across rape cases and their different trajectories through the criminal justice system. The legal and extra‐legal factors that have been identified in the previous literature as increasing attrition, such as relationship between victim and offender, vulnerability of victim, and evidential issues, were all seen to play some part in the attrition and trajectories of the cases discussed here, but were relevant to different degrees depending on whether the cases involved acquaintance, intimate domestic violence, or historical child sexual abuse. If we are to more effectively deal with the “justice gap” that exists in rape cases, an important aspect is to understand the differences between these groups of cases and the particular circumstance and needs of the victims in these different contexts.
Effects of four short‐chain fatty acids or salts on the dynamics of nitrogen transformations and intrinsic protease activity of alfalfa silage
Authors: Yuan XianJun , Wen AiYou , Desta Seare T , Dong ZhiHao , Shao Tao 
Published: October 2016

AbstractBACKGROUNDShort‐chain fatty salts have been widely used as food and forage preservatives because of their antimicrobial properties. This study evaluated the effects of four chemical compounds with antimicrobial properties on nitrogen transformations and intrinsic protease activity of alfalfa silage.RESULTSPotassium diformate (PD) and formic acid (FA) rapidly reduced silage pH. Silages treated with sodium diacetate (SD) and calcium propionate (CAP) had higher final peptide N concentrations than other silage. The free amino acid N contents in PD and FA treated silages were lower than other silages at all intervals of ensilage. The ammonia N concentrations in FA and PD silages were the lowest, followed by SD and CAP silages. As ensiling progressed, the aminopeptidase activity was completely lost by day 5 for FA and PD silages and inactive by day 7 for SD silage, while it remained active after day 7 for control and CAP silage. The carboxypeptidase activities in FA and PD silages were already reduced below 50% by day 1 of ensiling.CONCLUSIONPotassium diformate was as effective as formic acid in depressing the proteolysis, while sodium diacetate and calcium propionate were inferior to formic acid in protecting alfalfa proteins from being hydrolysed. © 2016 Society of Chemical Industry
Effect of postharvest methyl jasmonate treatment on fatty acid composition and phenolic acid content in olive fruits during storage
Authors: Flores Gema , Blanch Gracia Patricia , del Castillo María Luisa Ruiz 
Published: October 2016

AbstractBACKGROUNDThe nutritional effects of both table olives and olive oil are attributed not only to their fatty acids but also to antioxidant phenolics such as phenolic acids. Delays in oil processing usually result in undesirable oxidation and hydrolysis processes leading to formation of free fatty acids. These alterations create the need to process oil immediately after olive harvest. However, phenolic content decreases drastically during olive storage resulting in lower quality oil. In the present study we propose postharvest methyl jasmonate treatment as a mean to avoid changes in fatty acid composition and losses of phenolic acids during olive storage.RESULTSContents of fatty acids and phenolic acids were estimated in methyl jasmonate treated olives throughout 30‐day storage, as compared with those of untreated olives. Significant decreases of saturated fatty acids were observed in treated samples whereas increases of oleic, linoleic and linolenic acids were respectively measured (i.e. from 50.8% to 64.5%, from 7.2% to 9.1% and from 1.5% to 9.3%). Also, phenolic acid contents increased significantly in treated olives. Particularly, increases of gallic acid from 1.35 to 6.29 mg kg−1, chlorogenic acid from 9.18 to 16.21 mg kg−1, vanillic acid from 9.61 to 16.99 mg kg−1, caffeic acid from 5.12 to 12.55 mg kg−1, p‐coumaric acid from 0.96 to 5.31 mg kg−1 and ferulic acid from 4.05 to 10.43 mg kg−1 were obtained.CONCLUSIONMethyl jasmonate treatment is proposed as an alternative postharvest technique to traditional methods to guarantee olive oil quality when oil processing is delayed and olive fruits have to necessarily to be stored. © 2016 Society of Chemical Industry
Timing for a sustainable fertilisation of Glycine max by using HBED/Fe3+ and EDDHA/Fe3+ chelates
Authors: Martín‐Fernández Clara , López‐Rayo Sandra , Hernández‐Apaolaza Lourdes , Lucena Juan J 
Published: October 2016

AbstractBACKGROUNDEfficient use of Fe chelates is crucial to avoid environmental risks and reduce economic losses. HBED/Fe3+ has been recently approved by the European Union for soil fertilisation, but studies delving into the best timing for its application are necessary. In this work, a batch incubation experiment and two biological experiments were developed to determine the optimal physiological stage for a sustainable application of HBED/Fe3+ in soil fertilisation compared with EDDHA/Fe3+ fertilisers using 57Fe.RESULTSHBED/Fe3+ demonstrated a high durability in soils and soil materials, maintaining more than 80% of Fe chelated after 70 days, and its application at an early physiological stage resulted in a high Fe accumulation in soybean and soil after 36 days. In contrast, the stability of EDDHA/Fe3+ decreased because of the retention of its lowest stable isomers. The best timing for chelates application was confirmed in a 52 day experiment. The application of HBED/Fe3+ at the early stage increased the Fe translocation to fruits; while o,o‐EDDHA/Fe3+ accumulated more Fe in fruits when added at the fructification stage.CONCLUSIONThe high HBED/Fe3+ stability in calcareous soil requires a differentiate application timing, and its addition at early physiological stages leads into the most efficient fertilisation. © 2016 Society of Chemical Industry
Investigating impacts of oil and gas development on greater sage‐grouse
Authors: Green Adam W. , Aldridge Cameron L. , O'donnell Michael S. 
Published: October 2016

ABSTRACTThe sagebrush (Artemisia spp.) ecosystem is one of the largest ecosystems in western North America providing habitat for species found nowhere else. Sagebrush habitats have experienced dramatic declines since the 1950s, mostly due to anthropogenic disturbances. The greater sage‐grouse (Centrocercus urophasianus) is a sagebrush‐obligate species that has experienced population declines over the last several decades, which are attributed to a variety of disturbances including the more recent threat of oil and gas development. We developed a hierarchical, Bayesian state‐space model to investigate the impacts of 2 measures of oil and gas development, and environmental and habitat conditions, on sage‐grouse populations in Wyoming, USA using male lek counts from 1984 to 2008. Lek attendance of male sage‐grouse declined by approximately 2.5%/year and was negatively related to oil and gas well density. We found little support for the influence of sagebrush cover and precipitation on changes in lek counts. Our results support those of other studies reporting negative impacts of oil and gas development on sage‐grouse populations and our modeling approach allowed us to make inference to a longer time scale and larger spatial extent than in previous studies. In addition to sage‐grouse, development may also negatively affect other sagebrush‐obligate species, and active management of sagebrush habitats may be necessary to maintain some species. © 2016 The Wildlife Society.
Polypeptide‐Based Conjugates as Therapeutics: Opportunities and Challenges
Authors: Zagorodko Oleksandr , Arroyo‐Crespo Juan José , Nebot Vicent J. , Vicent María J. 
Published: October 2016

Synthetic polypeptides or polyamino acids have become a useful and multifunctional platform in advanced drug delivery studies. Nonetheless, the full potential of these systems has yet to be achieved. The final structure of polypeptide conjugates and their in vivo behavior are dependent on an extraordinarily complex pattern of interconnected physico‐chemical and structural parameters, making sophisticated directional design of such systems difficult and often unachievable. In this review, the authors aim to discuss the role of these parameters in the successful design of different drug delivery architectures and to delineate some basic correlations between structure, properties, and the biological behavior of polypeptide‐based conjugates.
image
Peptide Modified Electrospun Glycopolymer Fibers
Authors: Fiorani Andrea , Totsingan Filbert , Pollicino Antonio , Peng Yifeng , Focarete Maria Letizia , Gross Richard A. , Scandola Mariastella 
Published: October 2016

Oligo(Glu70‐co‐Leu30), a peptide synthesized by protease catalysis, is functionalized at the N‐terminus with a 4‐pentenoyl unit and grafted to polyLSL[6′Ac,6″Ac], a glycopolymer prepared by ring‐opening metathesis polymerization of lactonic sophorolipid diacetate. First, polyLSL[6'Ac,6”Ac] fiber mats are fabricated by electrospinning. Oxidation of the fiber mats and subsequent reaction with cysteamine lead to thiol‐functionalized fiber mats with no significant morphology changes. Grafting of the alkene‐modified oligopeptide to thiol‐functionalized polyLSL[6′Ac,6″Ac] fiber mats is achieved via “thiol‐ene” click reaction. X‐ray photoelectron spectroscopy analysis to characterize peptide grafting reveals that about 50 mol% of polyLSL[6′Ac,6′′Ac] repeat units at fiber surfaces are decorated with a peptide moiety, out of which about 1/3 of the oligo(Glu70‐co‐Leu30) units are physically adsorbed to polyLSL[6′Ac,6′′Ac]. The results of this work pave the way to precise engineering of polyLSL fiber mats that can be decorated with a potentially wide range of molecules that tailor surface chemistry and biological properties.
image
Stimuli‐Sensitive Injectable Hydrogels Based on Polysaccharides and Their Biomedical Applications
Authors: Thambi Thavasyappan , Phan V. H. Giang , Lee Doo Sung 
Published: October 2016

Stimuli‐sensitive injectable polymeric hydrogels are one of the promising delivery vehicles for the controlled release of bioactive agents. In aqueous solutions, these polymers are able to switch sol‐to‐gel transitions in response to various stimuli including pH, temperature, light, enzyme and magnetic field. Therapeutic agents, including chemotherapeutic agents, protein drugs or cells, are easily mixed with the low‐viscous polymer solution at room temperature. Therapeutic‐agents‐containing solutions are readily injected into target sites through syringe or catheter, which could form hydrogel depot and serve as bioactive molecules release carriers. In particular, they are convenient for in vivo injection in a minimally invasive manner. Owing to their ease of handling, hydrogel scaffolds encapsulated with a wide array of therapeutic agents including growth factors, cells or fillers have been used in regeneration or filling of the defect area. Therefore, injectable hydrogels found a variety of biomedical applications, such as drug delivery and tissue engineering. Here, we summarize the chemical designs and recent developments of polysaccharide‐based injectable hydrogels, giving a special attention to hydrogels prepared using amphiphilic polysaccharides for biomedical applications. Advantages and future perspectives of polysaccharide‐based injectable hydrogels are highlighted.
image
Neurological Nuance: Hodgkin lymphoma presenting with Guillain–BarrÉ syndrome
Authors: Anderson Dustin , Beecher Grayson , Steve Trevor A. , Jen Ho , Camicioli Richard , Zochodne Douglas W. 
Published: October 2016

ABSTRACTIntroductionHodgkin lymphoma (HL) is a common lymphoid malignancy rarely associated with Guillain–Barré syndrome (GBS). In most cases, GBS does not precede HL.MethodsWe describe a patient with acute inflammatory demyelinating polyneuropathy who fulfilled criteria for GBS that heralded undiagnosed HL.ResultsCerebrospinal fluid (CSF) studies revealed albuminocytologic dissociation with significant protein elevation (250 mg/dl). The patient worsened during intravenous immunoglobulin (IVIg) therapy. Constitutional symptoms with elevated inflammatory markers prompted further investigation, and imaging revealed an anterior mediastinal mass confirmed on biopsy to be HL. Chemotherapy yielded early clinical improvement.ConclusionsGBS preceding HL is rare, and this case highlights the importance of considering HL in the setting of GBS. Marked elevations in CSF protein, ongoing deterioration despite administration of IVIg, and constitutional symptoms with elevated inflammatory markers may be clues to possible HL‐induced GBS. Muscle Nerve 55: 601–604, 2017
Three dimensional elasto‐plastic interface for embedded beam elements with interaction surface for the analysis of lateral loading of piles
Authors: Turello Diego F. , Pinto Federico , Sánchez Pablo J. 
Published: October 2016

SummaryThis paper presents a numerical formulation for a three dimensional elasto‐plastic interface, which can be coupled with an embedded beam element in order to model its non‐linear interaction with the surrounding solid medium. The formulation is herein implemented for lateral loading of piles but is able to represent soil‐pile interaction phenomena in a general manner for different types of loading conditions or ground movements. The interface is formulated in order to capture localized material plasticity in the soil surrounding the pile within the range of small to moderate lateral displacements. The interface is formulated following two different approaches: (i) in terms of beam degrees of freedoms; and (ii) considering the displacement field of the solid domain. Each of these alternatives has its own advantages and shortcomings, which are discussed in this paper. The paper presents a comparison of the results obtained by means of the present formulation and by other well‐established analysis methods and test results published in the literature. Copyright © 2016 John Wiley & Sons, Ltd.
Synthetic quantitative MRI through relaxometry modelling
Authors: Callaghan Martina F. , Mohammadi Siawoosh , Weiskopf Nikolaus 
Published: October 2016

AbstractQuantitative MRI (qMRI) provides standardized measures of specific physical parameters that are sensitive to the underlying tissue microstructure and are a first step towards achieving maps of biologically relevant metrics through in vivo histology using MRI. Recently proposed models have described the interdependence of qMRI parameters. Combining such models with the concept of image synthesis points towards a novel approach to synthetic qMRI, in which maps of fundamentally different physical properties are constructed through the use of biophysical models. In this study, the utility of synthetic qMRI is investigated within the context of a recently proposed linear relaxometry model. Two neuroimaging applications are considered. In the first, artefact‐free quantitative maps are synthesized from motion‐corrupted data by exploiting the over‐determined nature of the relaxometry model and the fact that the artefact is inconsistent across the data. In the second application, a map of magnetization transfer (MT) saturation is synthesized without the need to acquire an MT‐weighted volume, which directly leads to a reduction in the specific absorption rate of the acquisition. This feature would be particularly important for ultra‐high field applications. The synthetic MT map is shown to provide improved segmentation of deep grey matter structures, relative to segmentation using T1‐weighted images or R1 maps. The proposed approach of synthetic qMRI shows promise for maximizing the extraction of high quality information related to tissue microstructure from qMRI protocols and furthering our understanding of the interrelation of these qMRI parameters.
Analysis of compaction and life‐time prediction of porous polymer membranes: influence of morphology, diffusion and creep behaviour
Authors: Handge Ulrich A 
Published: October 2016

AbstractIn membrane applications, large values of permeability and selectivity are generally desired during the whole period of application. The permeability of porous polymer membranes often is reduced by the effect of compaction. Compaction of polymer membranes is a time‐dependent process which is strongly determined by the viscoelastic properties of the polymer and its plasticisation caused by the feed medium (e.g. a liquid medium or a process gas in the case of porous support structures). In this study, the time‐dependent compaction of porous polymer membranes under pressure is modelled. The influence of viscoelastic and diffusion properties of the polymer material on the permeability of the membrane is analysed for different types of membrane morphologies. The life‐time of a porous polymer membrane is associated with the time at which the glass transition is achieved in a creep experiment. Equations are derived in order to estimate the maximum life‐time of polymer membranes based on compaction. The analysis reveals that the diffusion coefficient, the average retardation time in creep, the magnitude of creep compliance and the time–temperature–pressure shift factor strongly influence compaction of microporous membranes. Generally, a larger tortuosity at constant porosity yields a lower life‐time of the membrane. Buckling of cell struts is the dominant failure mechanism in porous membranes with a very high porosity and allows an estimation of life‐time. © 2016 Society of Chemical Industry
The New Prostate Cancer Grading System Does Not Improve Prediction of Clinical Recurrence After Radical Prostatectomy: Results of a Large, Two‐Center Validation Study
Authors: Dell'Oglio Paolo , Karnes Robert Jeffrey , Gandaglia Giorgio , Fossati Nicola , Stabile Armando , Moschini Marco , Cucchiara Vito , Zaffuto Emanuele , Karakiewicz Pierre I. , Suardi Nazareno , Montorsi Francesco , Briganti Alberto 
Published: October 2016

BACKGROUNDA new prostate cancer (PCa) grading system (namely, Gleason score‐GS‐ ≤6 vs. 3 + 4 vs. 4 + 3 vs. 8 vs. ≥9) was recently proposed and assessed on biochemical recurrence (BCR) showing improved predictive abilities compared to the commonly used three‐tier system (GS ≤6 vs. 7 vs. ≥8). We assessed the predictive ability of the five‐tier grade group (GG) system on harder clinical endpoint, namely clinical recurrence (CR).METHODSBetween 2005 and 2014, 9,728 clinically localized PCa patients were treated with radical prostatectomy (RP) at two tertiary referral centers. Kaplan–Meier curves, multivariable Cox regression analyses, and concordance index (C‐index) were used to assess CR after treatment according to four Gleason grade classifications at biopsy and RP: Group 1: ≤6 versus 7 versus ≥8; Group 2: ≤6 versus 3 + 4 vs. 4 + 3 versus ≥8; Group 3: ≤6 versus 7 versus 8 versus ≥9; Group 4: ≤6 versus 3 + 4 versus 4 + 3 versus 8 versus ≥9. Same analyses were repeated in patients who had BCR (n = 1,624). Decision curve analyses were performed to evaluate and compare the net benefit associated with the use of the four Gleason grade classifications.RESULTSOverall, 443 (4.6%) patients had CR. The hazard ratio of the GS 3 + 4, 4 + 3, 8, and ≥9 relative to GS ≤6 were 3.63, 5.93, 11.44, 18.08 and 4.93, 9.99, 15.31 and 25.12 in the pre‐ and post‐treatment models, respectively. The C‐index of the five‐tier GG system was slightly higher relative to the other 3 Gleason grade classifications both in the pre‐ (range: 0.001–0.006) and post‐treatment models (range: 0–0.008). Similar findings were observed when we focused our analyses in patients with BCR after RP. The use of the five‐tier GG system did not result into higher net‐benefit relative to the other three Gleason grade classifications.CONCLUSIONSThe difference in accuracy between the five‐tier GG system and the other Gleason grade classifications, using CR as an endpoint, is clinically negligible. Current evidence suggests that the five‐tier GG system represents a simplified user‐friendly scheme available for patient counseling rather than a new histopathological diagnostic system that improves the prediction of CR. Prostate 77:263–273, 2017. © 2016 Wiley Periodicals, Inc.
A perspective on management of Helicoverpa armigera: transgenic Bt cotton, IPM, and landscapes
Authors: Downes Sharon , Kriticos Darren , Parry Hazel , Paull Cate , Schellhorn Nancy , Zalucki Myron P 
Published: October 2016

AbstractHelicoverpa armigera is a major pest of agriculture, horticulture and floriculture throughout the Old World and recently invaded parts of the New World. We overview of the evolution in thinking about the application of area‐wide approaches to assist with its control by the Australian Cotton Industry to highlight important lessons and future challenges to achieving the same in the New World. An over‐reliance of broad‐spectrum insecticides led to Helicoverpa spp. in Australian cotton rapidly became resistant to DDT, synthetic pyrethroids, organophosphates, carbamates and endosulfan. Voluntary strategies were developed to slow the development of insecticide resistance, which included rotating chemistries and basing spray decisions on thresholds. Despite adoption of these practices, insecticide resistance continued to develop until the introduction of genetically modified cotton provided a platform for augmenting Integrated Pest Management in the Australian cotton industry. Compliance with mandatory resistance management plans for Bt cotton necessitated a shift from pest control at the level of individual fields or farms towards a coordinated area‐wide landscape approach. Our take‐home message for control of H. armigera is that resistance management is essential in genetically modified crops and must be season long and area‐wide to be effective. © 2016 Society of Chemical Industry