bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship of paraoxonase-1 and paraoxonase-3 with routine laboratory tests and oxidative stress in type 2 diabetes mellitus
Authors: Ucar Yagcı Yagmur , Yılmaz Bulbul Buket , Sut Necdet , Ozgun Eray 
Published: September 2024

Abstract

Objectives
We aimed to investigate the relationship between serum paraoxonase-1 (PON1) and paraoxonase-3 (PON3) levels and activities with hemoglobin A1c (HbA1c), serum fasting blood glucose, lipid profile, and oxidative stress in patients with type 2 diabetes mellitus (T2DM). Also, we aimed to examine PON1 and PON3 levels and activities in these patients according to the HbA1c goal in diabetes treatment and PON1192 phenotypes.

Methods
One hundred forty-one volunteers diagnosed with T2DM participated in this study. Serum PON1 and PON3 levels and activities, total oxidant status (TOS), and total antioxidant status (TAS) were measured. PON1192 phenotypes were determined by using PON1 activities. Also, HbA1c, serum fasting blood glucose, and lipid profile results, which were measured for routine examination on the same day as sample collection, were used for this study.

Results
There was a positive relationship between arylesterase and lactonase activities and high-density lipoprotein cholesterol (HDL-C), between lactonase activity and TAS, and a negative relationship between PON1 level and TAS in patients with T2DM. Our study also showed that PON3/HDL-C was higher in patients with HbA1c levels ≥7 %. Lactonase activities were higher in patients with PON1Q192Q and PON1Q192R phenotypes than in patients with PON1R192R phenotypes.

Conclusions
PON1 and PON3 levels and activities alone could not be associated with immediate or long-term blood glucose levels in patients with T2DM. Higher PON3/HDL-C in patients with HbA1c levels ≥7 % may show a protective role of PON3 in defense against higher glucose levels. Also, we found that the PON1192 phenotype can affect serum lactonase activity.
1-Nitronaphthalene, a non-OD, non-MDO polytype
Authors: Schöbinger Matthias , Stöger Berthold 
Published: September 2024

Abstract
Crystals of 1-nitronaphthalene were grown by evaporation of a methanol solution. The structure [P21/c, a = 13.2780(13) Å, b = 3.8131(3)° Å, c = 31.851(3) Å, β = 91.173(8), V = 1,612.3 Å3] was solved from a crystal twinned by twofold rotation about [100]. Twinning is explained by the polytype character: layers with (idealized) p2111 symmetry can connect via either 1‾ or 21 operations, leading to geometrically distinct pairs of layers. In the twin individuals, the two kinds of contacts alternate, at the composition plane two subsequent contacts of the same type are realized.
Synthesis and crystal structure of a tripeptide comprising a centrally placed non-coded aromatic γ-amino acid
Authors: Das Purak , Das Suven , Dutta Arpita 
Published: September 2024

Abstract
A protected tripeptide Boc-l-Leu-5-AIA-Aib-OMe was synthesized where 5-aminoisophthalic acid (5-AIA), a rigid non-coded aromatic γ-amino acid is incorporated as central residue. The single crystal X-ray diffraction study indicates that the peptide self-assembles into supramolecular sheet through intermolecular hydrogen bonding interaction N–H⋯O and π
···
π interaction.
EXTRACTION OF SULPHUR-CONTAINING AND POLYCYCLIC AROMATIC COMPOUNDS OF DIESEL FUEL WITH IMIDAZOLE-CONTAINING IONIC LIQUIDS
Authors: КОБОТАЕВА Н.С. , САВИНЫХ Ю.В. , СКОРОХОДОВА Т.С. 
Published: September 2024

Проведено исследование процесса экстракции серосодержащих соединений дизельного топлива (ДТ) ионными жидкостями (ИЖ) на основе имидазола с различными заместителями (бутил, октил, нонил, додецил, цетил) в положении 1 имидазольного кольца и определен состав серосодержащих соединений и полициклических ароматических углеводородов (ПАУ) методом хромато-масс-спектрометрии в исходном и очищенном ДТ. Определены оптимальные условия процесса экстракции: температура 30-35 °С, время экстракции 60 мин, соотношение ДТ/ИЖ = 1.66-2. Наиболее эффективным в качестве экстрагента серосодержащих соединений ДТ является 1-нонил-3-метилимидазолия бромид, позволяющий снизить общее содержание серы с 0.369 до 0.143 мас. %. Результаты исследования группового и индивидуального состава производных дибензотиофена (ДБТ) и ПАУ показали, что степень извлечения производных ДБТ и трициклических ароматических углеводородов составляет 66-72 %. В меньшей степени происходит извлечение нафталина и его гомологов - 37 %. Среди гомологов ДБТ наиболее полно извлекается диметилдибензотиофен.
The extraction of sulphur-containing compounds of diesel fuel (DF) with ionic liquids (IL) based on imidazole with various substituents (butyl, octyl, nonyl, dodecyl, cetyl) in position 1 of the imidazole ring has been studied; the composition of sulphur-containing compounds and polycyclic aromatic hydrocarbons (PAH) has been determined by gas chromatography - mass spectrometry in the initial and purified diesel fuel. The optimal extraction conditions are determined: temperature 30-35 °C, extraction time 60 min, DF/IL ratio 1.66-2. The most effective extractant for the sulphur-containing compounds of DF is 1-nonyl-3-methylimidazolium bromide, which allows reducing the total sulphur content from 0.369 to 0.143 wt%. Results of the studies of group and individual composition of dibenzothiophene (DBT) and PAH derivatives show that the degree of extraction of DBT derivatives and tricyclic aromatic hydrocarbons is 66-72%. Naphthalene and its homologues are extracted to a lesser extent - 37%. Among DBT homologues, dimethyldibenzothiophene is extracted most completely.
The war in Ukraine in light of international law
Authors: Lamm Vanda 
Published: September 2024

AbstractThe aggression and the ‘special military operation’ against Ukraine by the Russian Federation have, since their outset, implied not only the violation of fundamental customary and treaty norms of international law, but, at the same time also undermine the foundations of the contemporary international legal order. The ‘special military operation’ violates several universal international conventions in the elaboration of which the predecessor state of contemporary Russia, the Soviet Union had a definitive role; furthermore, it expressly breaches Russian undertakings concerning respect for the independence and sovereignty of Ukraine. Since in this case the aggressor state is a permanent member of the UN Security Council, thus, instead of the Council, the emergency special session of the UN General Assembly proceeds on the basis of the Uniting for Peace resolution and makes recommendations for collective measures to the Member States. The present study discusses the most important international norms breached with the aggression and during the war, the resolutions of the emergency special sessions of the UN General Assembly, the post-war situation, as well as the issue of remedy and reparation due to Ukraine.
Pulmonary hypertension in ischemic heart failure: a pilot study
Authors: Mareyeva V. A. , Bogdanova A. A. , Nikiforova Т. A. , Klimenko A. A. 
Published: September 2024

Aim. To evaluate the role of cardiopulmonary system assessment in a group of patients with pulmonary hypertension (PH) associated with ischemic heart failure (HF) with the right ventricular-pulmonary arterial (RV-PA) coupling.Material and methods. Forty stable patients were examined. The patients were divided into 3 groups depending on the left ventricle ejection fraction (LVEF). PH was established by using expert transthoracic echocardiography. RV-PA coupling was calculated by 2 following ways: as tricuspid annular plane systolic excursion (TAPSE)/pulmonary artery systolic pressure (PASP) ratio and as TAPSE´Pulmonary Artery Aceleration Time (pACT) multiplication.Results. The patients included in the study were mainly men (73,8%), functional class PH II-III (95,2%), stage IIB CHF (62%). The highest values of TAPSE (18,6±3 mm) and RV-PA coupling (0,64±0,42 mm/mm Hg) were found in the patients with preserved LVEF. In the general cohort, high level of NT-proBNP corresponds to reduced values of RVPA coupling (rs=-0,563) and TAPSE (rs=-0,666; p<0,01). The severity of PH directly affects the level of NT-proBNP (p<0,01). As the stage of HF and PH functional class increases, the indicators of PASP, inferior vena cava diameter and NT-proBNP level significantly increase, as well as TAPSE and RV-PA coupling decrease (p<0,05). Different calculating methods of RV-PA coupling has a strong correlation (rs=0,832; p<0,01).Conclusion. The right heart and RV-PA coupling assessment in patients with ischemic HF of origin is of significant value for the early diagnosis of PH and timely clinical decision-making.
Earthquake Magnitude Estimation through Mixed-Effects Ground-Motion Modeling of Early P-Wave Arrivals
Authors: Sharma Nitin , Ravi Kumar Mangalampally , Vijaya Raghavan Raman 
Published: September 2024

Abstract
A regional earthquake early warning system (EEWS) warrants potential predictive models to accurately extract earthquake parameters like magnitude and intensity from the first few seconds of a P-wave arrival. In this study, a maiden predictive model depicting the relationship between peak displacement amplitude (Pd) and magnitude (ML) is proposed for the western Himalayan region through a mixed-effects regression and compared with those from similar tectonic regimes. This model for EEWS is derived from the vertical-component waveforms with a high signal-to-noise ratio, using three different time-window lengths (Td) of 1, 2, and 3 s, just after the P onset. Waveforms from 83 earthquakes in the magnitude (ML) range of 3 and 5.5 registered at 27 strong motion seismic stations are used for this purpose. The hypocentral distance range varies between 5 and 264 km. A comparative analysis between the models obtained through linear and linear mixed-effects (lme) regression reveals that the latter is robust. It is observed that the intra-event uncertainties are significantly reduced after site corrections and contribute more toward the total variabilities, compared to the inter-event uncertainties. Based on the results from this study, it is emphasized that the local site effects should be incorporated while developing the predictive models for EEWS. Importantly, the displacement magnitude (Mpd) derived from Pd values, accurately matches with ML, even for the data not used to derive the model, lending credence to the final model. A scaling relation between the peak ground velocities (PGV) and Pd values is also established to evaluate the seismic hazard levels. Advocating that the adapted models should be calibrated for a targeted region, the dissimilarities among different models and the implications from epistemic uncertainties are also discussed in the present study.
Safety and efficacy evaluation of plain OTC-HCL in acute and subacute toxicity tests and infected mice
Authors: Pharande Rajesh Raghunanth , Mane Shubham Tukaram , Gandge Rajashree Shivkumar , Gulavane Sarita U , Sole Sushant S. , Thorat Varsha D 
Published: September 2024

The study aimed to evaluate the safety and efficacy of plain Oxytetracycline hydrochloride (OTC-HCL) in mice experimentally infected with 544 strain. The safety of plain OTC-HCL was assessed through acute and subacute toxicity testing. The LD value was determined, and hematologic, biochemical, and histopathological analyses were performed. For efficacy evaluation, mice were intraperitoneally injected with 3 × 10^6 CFU of 544 in 0.5 ml. Following infection, the mice received 25 mg/kg of plain OTC-HCL intravenously either daily or on alternate days for 21 days, starting from day 14 post-infection. Efficacy was assessed by measuring the logarithmic decrease in counts in the liver, lymph nodes, and spleen on days 1, 7, and 14 after treatment. Plain OTC-HCL has an LD of greater than 250 mg/kg. In both acute and subacute toxicity evaluations, the hematologic and biochemical data of the drug were within the normal range. Histopathology studies revealed no significant changes in the safety studies. In the subacute toxicity study, the drug was administered to mice received plain OTC-HCl @ 25 mg/kg intravenously for 21 days. Efficacy was measured by the decrease of counts in the liver, lymph nodes, and spleen. Plain OTC-HCL was found to be safe in both acute and subacute toxicity tests and effectively reduced the infection load of in mice. Our findings and novelties are 1) LDis more than 250 mg/kg for plain OTC-HCL by intravenously as a single dose. 2) Histopathology indicates that there is no organ toxicity for plain OTC-HCL in safety studies. 3) Plain OTC-HCL was found to be effective in reducing the infection load in -infected mice.
Study on the role of iron chelators in the management of iron overload among transfusion-dependent thalassemia (TDT) pediatric patients
Authors: Krishnakanth K  , Abubakar Shaik Mohammad , Chopra Jhansi Vani , Elizabeth B  
Published: September 2024

This study aims to investigate the efficacy and safety of Deferasirox, an oral iron chelator, in reducing iron burden in pediatric patients with transfusion-dependent beta-thalassemia. Thalassemia syndromes, particularly beta-thalassemia, are inherited hemoglobin disorders requiring regular blood transfusions, leading to iron overload and subsequent complications. Effective management of iron overload is crucial to prevent morbidity and mortality. It was a descriptive observational study on Children between the ages of 2 years and 12 years who present with transfusion-dependent thalassemia and areon blood transfusion and develop iron overload, which is evaluated by serum ferritin levels of more than 2000mcg/l are administered iron chelator Deferasirox (14 mg/kg/d)and patients are evaluated for myocardial, hepatic, pancreatic iron burden and conditions of iron toxicity with the help of Cardiac MRI T2, LIC (Liver Iron Concentration), MRI T2 Pancreas, LVEF (Left Ventricular Ejection Fraction). A total of 22 patients enrolled in the study; significant reductions were observed in mean serum ferritin levels (2,388 mcg/dl to 2,054 mcg/dl, p=0.0009), transferrin saturation (70.45% to 64.32%, p=0.00005), and serum transaminases (44.55 U/L to 40.27 U/L, p=0.003) at 6 months. Cardiac MRI T2* increased from 19.55 ms to 22.95 ms (p=0.045) at the end of 6 months and at the end of 12 months from 19.55 to 28.23 (p=0.0016), and LIC reduced from 20.73 mg Fe/g dw to 11.59 mg Fe/g dw (p=0.00005). Pancreatic T2 improved from 15.96 ms to 20.23 ms at 12 months (p=0.007). A transient increase in serum creatinine was observed at 6 months from 0.64+/-0.14 mg/dL to 0.7+/-0.13mg/dL(p=0.009), which returned to normal at the end of 12 months to 0.63 mg/dL, no additional therapy-related adverse events were reported. Deferasirox has demonstrated significant efficacy in reducing iron overload in pediatric patients with transfusion-dependent beta thalassemia over a 12-month period. The substantial improvements in serum ferritin, cardiac MRI T2*, LIC, transferrin saturation, and pancreatic T2, coupled with its excellent safety profile, support the use of DFX as a cornerstone in the management of iron overload in this vulnerable population.
Actividad alelopática de extractos acuosos de especies arbóreas sobre la germinación y crecimiento inicial de dos malezas
Authors: Almada Ruiz Victor Gabriel , Reyes Olivas Álvaro , Lugo García Gabriel Antonio , Ortega Arenas Laura Delia , Romero Félix Celia Selene , Sánchez Soto Bardo Heleodoro 
Published: September 2024

En la búsqueda de opciones sostenibles de manejo de las arvenses Convolvulus arvensis L. y Portulaca oleracea L., se evaluó in vitro el potencial de inhibición de germinación y crecimiento inicial del extracto acuoso de fruto, hoja y corteza de las especies arbóreas, con características alelopáticas, Eucalyptus globulus Labill. y Schinus terebinthifolius Raddi. La inhibición de germinación y crecimiento se evaluó al exponer semillas de las arvenses, dispuestas dentro de una caja Petri, a la aspersión del extracto a diferentes concentraciones. Los extractos de fruto y hoja de S. terebinthifolius, así como el de hoja de E. globulus, inhibieron la germinación y crecimiento de ambas malezas a partir del formulado al 2.5 %. La actividad biológica de los extractos se relacionó positivamente con la concentración. Los resultados sugieren que los extractos de las arbóreas representan una herramienta útil en el manejo agroecológico de las dos arvenses.
REMOCIÓN DE CONTAMINANTES EN AGUAS RESIDUALES MEDIANTE HUMEDALES BIOINGENIERILES DOMICILIARIOS CON DIFERENTE TIPO DE SUSTRATO Y SEMBRADOS CON Strelitzia Reginae
Authors: González-Rivadeneyra D. , Marín-Muñiz J.L , Hernández-Alarcón M.H. 
Published: September 2024

El tratamiento de aguas residuales es una necesidad global y de gran interés, ya que la demanda de agua es cada vez mayor, además hay un volumen creciente de residuos biológicos y químicos que son arrojados directamente a los cuerpos de agua, lo que lleva a optar por una alternativa sustentable que remueva contaminantes del agua sin un control de operación complejo. El presente estudio tuvo como objetivo proponer y validar el uso de humedales construidos (HC) domiciliarios sembrados con ave de paraíso (Strelitzia reginae) para tratar aguas residuales. La etapa experimental se realizó en la localidad de Pastorías, Actopan (Veracruz) y consistió en 8 mesocosmos: 2 HC sembrados con Strelitzia reginae en piedra poroso de río como sustrato, 2 HC con la misma especie, pero sembrados en tezontle (piedra volcánica) y 2 HC solo con piedras, más 2 HC solo con tezontle, como controles. Las unidades operaron de manera continua durante 6 meses (marzo-agosto).
La vegetación ornamental se adaptó a las condiciones de HC, en ambos sustratos el crecimiento fue similar. Los sustratos utilizados funcionaron similarmente en las remociones de los contaminantes, mejores resultados de remoción fueron observadas en presencia de la planta ornamental, en los mesocosmos con presencia de vegetación, tanto para sólidos totales (SST), amonio (N-NH4), fosfatos (P-PO4) y sulfatos (SO4) las remociones fueron hasta de 37%, 45%, 63% y 80%, respectivamente. Los HC con plantas ornamentales pueden realizar un tratamiento eficiente en las aguas residuales domésticas, Cabe mencionar que los sustratos son de bajo costo y fácil obtención.
Palabras clave: Aguas residuals; Contaminantes; Humedales Construidos; Ornamentales; Remociones; Sustratos Locales
Experience of transcultural nursing for migrant workers in covid-19 field hospitals: a qualitative study in Samut Sakhon Province, Thailand
Authors: Arayathanitkul Bussarin , Bandansin Jutarat , Lamtrakul Su-ari , Kwiensungnoen Pacharaphorn , Eaksamai Suwaluck 
Published: September 2024

Introduction: This study aimed to explore Thai nurses’ experiences of caring for migrant workers with COVID-19 in a field hospital.
Methods: This is a qualitative study. An in-depth interview was used to collect data from nine nurses between May and September 2022. The data were transcribed verbatim and content analysis was performed to analyze the data. Interviews with interpreters and co-workers of participants in the field hospital were used to examine data triangulation.
Results: Three themes described the transcultural nursing experiences of nurses caring for COVID-19 migrant patients: 1) the role of nurses in a field hospital caring for migrant patients with COVID-19, 2) care delivery through the nursing process, and 3) cultural competence and transcultural nursing approach under mask and personal protective equipment for migrants with COVID-19 in the field hospital.
Conclusions: Nurses' experiences highlighted the crucial role of managing patient care resources, coordinating with other healthcare professionals, and providing direct patient care in various situations in a field hospital. Despite mental and cultural care challenges, nurses still embrace transcultural nursing for migrant patients, addressing cross-cultural communication and basic needs and respecting beliefs related to religion to provide optimal care.
Keywords: transcultural nursing, covid-19 field hospital, migrant workers, migrant patients
Spiritual needs throughout childbirth: a cross-sectional study among working women at the largest university in Brunei
Authors: Adnan Ahmad Shamil Haji Mohd , Rahman Hanif Abdul , Sharbini Sharimawati , Abdul-Mumin Khadizah H. 
Published: September 2024

Introduction: This study evaluates spiritual needs throughout childbirth of women who are working in higher education setting.
Methods: Healthcare professionals have fundamental roles in ensuring the spiritual needs of women throughout childbirth are met. This concurs with the World Health Organization’s definition of health that holistically comprises of physical/biological, psychological/mental, social and spiritual aspects. This study evaluates spiritual needs throughout childbirth of women who are working in higher education setting.
Results: A total 80 female staff participated in the study. Three out of the five domains of the spiritual needs scale were found to be the most frequently addressed as interpreted from the mean score. These are: “Finding meaning and purpose” 4.2 (0.6) followed by “Religious needs” 4.1 (0.7) and “Seeking peace” 4.0 (0.6). Those aged 40 and above scored 4.3 (0.8), which is significantly higher (P = 0.048) for “Finding meaning and purpose” compared to other age groups. Those who had four or more children had significantly higher spiritual needs for “Finding meaning and purpose” 4.2 (0.6) and “Seeking peace” 4.4 (0.7) compared to those having one to three children.
Conclusions: The findings of this study suggest that spiritual needs are essential during childbirth. “Finding meaning and purpose” and “Seeking peace” were identified to be the most common spiritual needs during childbirth. As women age and have more children, their spiritual needs increase. This study contributes positively toward the improvement of care, particularly spiritual aspects where evidence is scarce.
Keywords: Assessment, Brunei, Childbirth, Women, Spiritual
Determinants of parents’ readiness for face-to-face learning among elementary school children during the new normal
Authors: Kurnia Iqlima Dwi , Arief Yuni Sufyanti , Rachmawati Praba Diyan , Krisnana Ilya , Istiqomah Yutri , Ananta Syafira Dwi , Pratuma Rithpho 
Published: September 2024

Introduction: This study aimed to identify factors influencing the readiness of parents with elementary school-age children for face-to-face learning using the Health Promotion Model (HPM).
Methods: This was a cross-sectional study. The study population consisted of parents of elementary school students in Surabaya. A purposive sampling method was used to select 395 respondents. The independent variables included motivation, parental knowledge, perceived benefits, perceptions of barriers, self-efficacy, interpersonal factors, situational factors, and commitment. The dependent variable was parental behavior in face-to-face learning readiness. Data were collected using a validated and reliable questionnaire. Data analysis was conducted using a logistic regression test, with a significance level of α ≤ 0.05.
Results: Most parents were 37 years old, and children in the 5th grade of elementary school. Most of the parents' motivation was in the sufficient category (57%). The parents’ knowledge of COVID-19 was good (66.8%). Most parents had a good perception of benefits (68.4%), and the perception of barriers was sufficient (59.7%). Good self-efficacy was observed in only 49% of cases, and interpersonal and situational factors accounted for 99.7% and 100%, respectively. Meanwhile, regarding parental readiness for face-to-face learning, the majority exhibited good behavior (96.2%). The factors that influenced parental behavior in face-to-face learning readiness were parental knowledge (0.010), perceived benefits (0.019), and commitment (0.029).
Conclusions: Good knowledge, perceived benefits, and parental commitment are factors that influence parents' readiness to participate in face-to-face learning.
Keywords: COVID-19, face-to-face learning, good health and well-being, Health promotion model (HPM), parents