bluuebunny/crossref_metadata_2025_split huggingface dataset:
Social support networks of older migrants in England and Wales: the role of collectivist culture
Authors: BURHOLT VANESSA , DOBBS CHRISTINE , VICTOR CHRISTINA 
Published: February 2017

ABSTRACTThis article tests the fit of a social support network typology developed for collectivist cultures to six migrant populations living in England and Wales. We examine the predictive utility of the typology to identify networks most vulnerable to poor quality of life and loneliness. Variables representing network size, and the proportion of the network classified by gender, age, kin and proximity, were used in confirmatory and exploratory latent profile analysis to fit models to the data (N = 815; Black African, Black Caribbean, Indian, Pakistani, Bangladeshi and Chinese). Multinomial logistic regression examined associations between demographic variables and network types. Linear regression examined associations between network types and wellbeing outcomes. A four-profile model was selected.Multigenerational Household: Younger Familynetworks were most robust with lowest levels of loneliness and greatest quality of life.Restricted Non-kinnetworks were least robust.Multigenerational Household: Younger Familynetworks were most prevalent for all but the Black Caribbean migrants. The typology is able to differentiate between networks with multigenerational households and can help identify vulnerable networks. There are implications for forecasting formal services and variation in networks between cultures. The use of a culturally appropriate typology could impact on the credibility of gerontological research.
Watching over me: positive, negative and neutral perceptions of in-home monitoring held by independent-living older residents in an Australian pilot study
Authors: BRADFORD DANA KAI , KASTEREN YASMIN VAN , ZHANG QING , KARUNANITHI MOHAN 
Published: February 2017

ABSTRACTWith an increase in the proportion of Australians aged over 65, and high government expenditure on residential care, there is a strong imperative to find smart, safe solutions to support older people to stay in their own homes. There is a growing interest in Australia for assistive technologies that provide home monitoring to promote health and wellbeing. This solution will only be viable if it meets with the expectations of older residents and their families. In the first smart homes pilot in Australia, we sought to ascertain barriers and facilitators of this technology. There was an overall positive response to the system, despite a slight tendency for residents to modify their behaviour due to perceived surveillance. Positive outcomes included increases in family communication, health autonomy and advances in technology uptake. Our findings suggest that a combination of considered placement of in-home technology, straightforward medical devices and a supportive human element will ensure that the technology meets the balance of service provision and preservation of dignity. Smart homes could mitigate the challenges associated with aged care while affording peace of mind for seniors and families.
‘We've had our sex life way back’: older care home residents, sexuality and intimacy
Authors: SIMPSON PAUL , WILSON CHRISTINE BROWN , BROWN LAURA J. E. , DICKINSON TOMMY , HORNE MARIA 
Published: February 2017

ABSTRACTOlder care home residents are excluded from the sexual imaginary. Based on a consultative study involving interviews with three residents, three female spouses of residents and two focus groups of care home staff (N = 16), making an overall sample of 22 study participants, we address the neglected subject of older residents' sexuality and intimacy needs. Using thematic analysis, we highlight how residents’ and spouses’ accounts of sexuality and intimacy can reflect an ageist erotophobia occurring within conditions of panoptical control that help construct residents as post-sexual. However, not all accounts contributed to making older residents’ sexuality appear invisible or pathological. Some stories indicated recuperation of identities and the normalisation of relationships with radically changed individuals,e.g.because of a dementia. We also examine care home staff accounts of the discursive obstacles that frustrate meeting residents’ needs connected with sexuality and intimacy. Simultaneously, we explore staffs’ creative responses to dilemmas which indicate approaches to sexuality driven more by observed needs than erotophobic anxiety and governance, as well as panoptical surveillance.
Neuropsychological performance changes following subthalamic versus pallidal deep brain stimulation in Parkinson’s disease: a systematic review and metaanalysis
Authors: Elgebaly Ahmed , Elfil Mohamed , Attia Attia , Magdy Mayar , Negida Ahmed 
Published: February 2017

BackgroundStudies comparing subthalamus (STN) and globus pallidus internus (GPi) deep brain stimulation (DBS) for the management of Parkinson’s disease in terms of neuropsychological performance are scarce and heterogeneous. Therefore, we performed a systematic review and metaanalysis to compare neuropsychological outcomes following STN DBS versus GPi DBS.MethodsA computer literature search of PubMed, the Web of Science, and Cochrane Central was conducted. Records were screened for eligible studies, and data were extracted and synthesized using Review Manager (v. 5.3 for Windows).ResultsSeven studies were included in the qualitative synthesis. Of them, four randomized controlled trials (n=345 patients) were pooled in the metaanalysis models. The standardized mean difference (SMD) of change in the Stroop color-naming test favored the GPi DBS group (SMD=–0.31,p=0.009). However, other neuropsychological outcomes did not favor either of the two groups (Stroop word-reading:SMD=–0.21,p=0.08; the Wechsler Adult Intelligence Scale (WAIS) digits forward:SMD=0.08,p=0.47; Trail Making Test Part A:SMD=–0.05,p=0.65; WAIS–R digit symbol:SMD=–0.16,p=0.29; Trail Making Test Part B:SMD=–0.14,p=0.23; Stroop color–word interference:SMD=–0.16,p=0.18; phonemic verbal fluency: bilateral DBSSMD=–0.04,p=0.73, and unilateral DBSSMD=–0.05,p=0.83; semantic verbal fluency: bilateral DBSSMD=–0.09,p=0.37, and unilateral DBSSMD=–0.29,p=0.22; Boston Naming Test:SMD=–0.11,p=0.33; Beck Depression Inventory: bilateral DBSSMD=0.15,p=0.31, and unilateral DBSSMD=0.36,p=0.11).ConclusionsThere was no statistically significant difference in most of the neuropsychological outcomes. The present evidence does not favor any of the targets in terms of neuropsychological performance.
Strip-tillage reduces productivity in organically managed grain and forage cropping systems in the Upper Midwest, USA
Authors: Weyers Sharon L. , Archer David W. , Forcella Frank , Gesch Russ , Johnson Jane M.F. 
Published: February 2017

AbstractTillage is decreasing globally due to recognized benefits of fuel savings and improved soil health in the absence of disturbance. However, a perceived inability to control weeds effectively and economically hinders no-till adoption in organic production systems in the Upper Midwest, USA. A strip-tillage (ST) strategy was explored as an intermediate approach to reducing fuel use and soil disturbance, and still controlling weeds. An 8-year comparison was made between two tillage approaches, one primarily using ST the other using a combination of conventional plow, disk and chisel tillage [conventional tillage (CT)]. Additionally, two rotation schemes were explored within each tillage system: a 2-year rotation (2y) of corn (Zea mays L.), and soybean (Glycine max [L.] Merr.) with a winter rye (Secale cereale L.) cover crop; and a 4-year rotation (4y) of corn, soybean, spring wheat (Triticum aestivum L.) underseeded with alfalfa (Medicago sativa L.), and a second year of alfalfa. These treatments resulted in comparison of four main management systems CT-2y, CT-4y, ST-2y and ST-4y, which also were managed under fertilized and non-fertilized conditions. Yields, whole system productivity (evaluated with potential gross returns), and weed seed densities (first 4 years) were measured. Across years, yields of corn, soybean and wheat were greater by 34% or more under CT than ST but alfalfa yields were the same. Within tillage strategies, corn yields were the same in 2y and 4y rotations, but soybean yields, only under ST, were 29% lower in the fertilized 4y than 2 yr rotation. In the ST-4y system yields of corn and soybean were the same in fertilized and non-fertilized treatments. Over the entire rotation, system productivity was highest in the fertilized CT-2y system, but the same among fertilized ST-4y, and non-fertilized ST-2y, ST-4y, and CT-4y systems. Over the first 4 years, total weed seed density increased comparatively more under ST than CT, and was negatively correlated to corn yields in fertilized CT systems and soybean yields in the fertilized ST-2y system. These results indicated ST compromised productivity, in part due to insufficient weed control, but also due to reduced nutrient availability. ST and diverse rotations may yet be viable options given that overall productivity of fertilized ST-2y and CT-4y systems was within 70% of that in the fertilized CT-2y system. Closing the yield gap between ST and CT would benefit from future research focused on organic weed and nutrient management, particularly for corn.
Mesenchymal stem cells in alleviating sepsis-induced mice cardiac dysfunction via inhibition of mTORC1-p70S6K signal pathway
Authors: Huang Wei , Fan Wensi , Wang Yabin , Han Dong , Li Xiujuan , Li Shuang , Li Congye , Xu Bin , Huang Yuesheng , Fu Xiaobin , Cao Feng 
Published: February 2017

AbstractSepsis-induced cardiac dysfunction remains a major cause of morbidity and mortality in patients suffered from severe trauma. Mesenchymal stem cells (MSCs) -based treatment has been verified as a promising approach to mitigate the sepsis-induced cardiac dysfunction, but the mechanism is still ambiguous. Thus, our study was designed to explore the potential role of MSCs in sepsis-induced cardiac dysfunction. In vivo bioluminescence imaging revealed 80% acute donor cell death of bone marrow-derived MSCs (BM-MSCs) within 3 days after transplantation. However, echocardiography demonstrated that systolic function in wild-type mice group were reduced after sepsis, while the cardiac function was relatively well persevered in cardiac-conditional deletion of Raptor (component of mTORC1 complex) mice group. Raptor KO group treated with BM-MSCs appeared better cardiac function than other groups (P<0.05). In vitro cell study revealed that co-culture of H9C2 (Raptor-Knock down) and BM-MSC could attenuate the level of proinflammatory cytokines and promote the expression of anti-inflammatory cytokine accompanied by mTORC2-Akt activation (P<0.05). In contrast, co-culture H9C2 (Raptor-O.E) and BM-MSC could aggravate the inflammatory response accompanied by the activation of mTORC1-p70S6K and inhibition of mTORC2-Akt (P<0.05). The immunomodulatory property of MSC is related to the inhibition of mTORC1-p70S6K and activation of mTORC2-Akt signaling pathway. mTORC1-p70S6K and mTORC2-Akt pathways were involved in the therapeutic adjuncts of MSC. The possible mechanism due to MSC`s immunomodulatory property through activation of mTORC2-Akt and inhibition of mTORC1-p70S6K signal pathways which may lead to modulate the expression of inflammation cytokines.
Controllable alignment of elongated microorganisms in 3D microspace using electrofluidic devices manufactured by hybrid femtosecond laser microfabrication
Authors: Xu Jian , Kawano Hiroyuki , Liu Weiwei , Hanada Yasutaka , Lu Peixiang , Miyawaki Atsushi , Midorikawa Katsumi , Sugioka Koji 
Published: February 2017

AbstractThis paper presents a simple technique to fabricate new electrofluidic devices for the three-dimensional (3D) manipulation of microorganisms by hybrid subtractive and additive femtosecond (fs) laser microfabrication (fs laser-assisted wet etching of glass followed by water-assisted fs laser modification combined with electroless metal plating). The technique enables the formation of patterned metal electrodes in arbitrary regions in closed glass microfluidic channels, which can spatially and temporally control the direction of electric fields in 3D microfluidic environments. The fabricated electrofluidic devices were applied to nanoaquariums to demonstrate the 3D electro-orientation of Euglena gracilis (an elongated unicellular microorganism) in microfluidics with high controllability and reliability. In particular, swimming Euglena cells can be oriented along the z-direction (perpendicular to the device surface) using electrodes with square outlines formed at the top and bottom of the channel, which is quite useful for observing the motions of cells parallel to their swimming directions. Specifically, z-directional electric field control ensured efficient observation of manipulated cells on the front side (45 cells were captured in a minute in an imaging area of ~160×120 μm), resulting in a reduction of the average time required to capture the images of five Euglena cells swimming continuously along the z-direction by a factor of ~43 compared with the case of no electric field. In addition, the combination of the electrofluidic devices and dynamic imaging enabled observation of the flagella of Euglena cells, revealing that the swimming direction of each Euglena cell under the electric field application was determined by the initial body angle.
Synergy of ammonium chloride and moisture on perovskite crystallization for efficient printable mesoscopic solar cells
Authors: Rong Yaoguang , Hou Xiaomeng , Hu Yue , Mei Anyi , Liu Linfeng , Wang Ping , Han Hongwei 
Published: February 2017

AbstractOrganometal lead halide perovskites have been widely used as the light harvester for high-performance solar cells. However, typical perovskites of methylammonium lead halides (CH3NH3PbX3, X=Cl, Br, I) are usually sensitive to moisture in ambient air, and thus require an inert atmosphere to process. Here we demonstrate a moisture-induced transformation of perovskite crystals in a triple-layer scaffold of TiO2/ZrO2/Carbon to fabricate printable mesoscopic solar cells. An additive of ammonium chloride (NH4Cl) is employed to assist the crystallization of perovskite, wherein the formation and transition of intermediate CH3NH3X·NH4PbX3(H2O)2 (X=I or Cl) enables high-quality perovskite CH3NH3PbI3 crystals with preferential growth orientation. Correspondingly, the intrinsic perovskite devices based on CH3NH3PbI3 achieve an efficiency of 15.6% and a lifetime of over 130 days in ambient condition with 30% relative humidity. This ambient-processed printable perovskite solar cell provides a promising prospect for mass production, and will promote the development of perovskite-based photovoltaics.
Cost-effectiveness of massively parallel sequencing for diagnosis of paediatric muscle diseases
Authors: Schofield Deborah , Alam Khurshid , Douglas Lyndal , Shrestha Rupendra , MacArthur Daniel G. , Davis Mark , Laing Nigel G. , Clarke Nigel F. , Burns Joshua , Cooper Sandra T. , North Kathryn N. , Sandaradura Sarah A. , O’Grady Gina L. 
Published: February 2017

AbstractChildhood-onset muscle disorders are genetically heterogeneous. Diagnostic workup has traditionally included muscle biopsy, protein-based studies of muscle specimens, and candidate gene sequencing. High throughput or massively parallel sequencing is transforming the approach to diagnosis of rare diseases; however, evidence for cost-effectiveness is lacking. Patients presenting with suspected congenital muscular dystrophy or nemaline myopathy were ascertained over a 15-year period. Patients were investigated using traditional diagnostic approaches. Undiagnosed patients were investigated using either massively parallel sequencing of a panel of neuromuscular disease genes panel, or whole exome sequencing. Cost data were collected for all diagnostic investigations. The diagnostic yield and cost effectiveness of a molecular approach to diagnosis, prior to muscle biopsy, were compared with the traditional approach. Fifty-six patients were analysed. Compared with the traditional invasive muscle biopsy approach, both the neuromuscular disease panel and whole exome sequencing had significantly increased diagnostic yields (from 46 to 75% for the neuromuscular disease panel, and 79% for whole exome sequencing), and reduced the cost per diagnosis from USD$16,495 (95% CI: $12,413–$22,994) to USD$3706 (95% CI: $3086–$4453) for the neuromuscular disease panel and USD$5646 (95% CI: $4501–$7078) for whole exome sequencing. The neuromuscular disease panel was the most cost-effective, saving USD$17,075 (95% CI: $10,654–$30,064) per additional diagnosis, over the traditional diagnostic pathway. Whole exome sequencing saved USD$10,024 (95% CI: $5795–$17,135) per additional diagnosis. This study demonstrates the cost-effectiveness of investigation using massively parallel sequencing technologies in paediatric muscle disease. The findings emphasise the value of implementing these technologies in clinical practice, with particular application for diagnosis of Mendelian diseases, and provide evidence crucial for government subsidy and equitable access.
Differences in place of death between lung cancer and COPD patients: a 14-country study using death certificate data
Authors: Cohen Joachim , Beernaert Kim , Van den Block Lieve , Morin Lucas , Hunt Katherine , Miccinesi Guido , Cardenas-Turanzas Marylou , Onwuteaka-Philipsen Bregje , MacLeod Rod , Ruiz-Ramos Miguel , Wilson Donna M , Loucka Martin , Csikos Agnes , Rhee Yong-Joo , Teno Joan , Ko Winne , Deliens Luc , Houttekier Dirk 
Published: February 2017

AbstractChronic obstructive pulmonary disease and lung cancer are leading causes of death with comparable symptoms at the end of life. Cross-national comparisons of place of death, as an important outcome of terminal care, between people dying from chronic obstructive pulmonary disease and lung cancer have not been studied before. We collected population death certificate data from 14 countries (year: 2008), covering place of death, underlying cause of death, and demographic information. We included patients dying from lung cancer or chronic obstructive pulmonary disease and used descriptive statistics and multivariable logistic regressions to describe patterns in place of death. Of 5,568,827 deaths, 5.8% were from lung cancer and 4.4% from chronic obstructive pulmonary disease. Among lung cancer decedents, home deaths ranged from 12.5% in South Korea to 57.1% in Mexico, while hospital deaths ranged from 27.5% in New Zealand to 77.4% in France. In chronic obstructive pulmonary disease patients, the proportion dying at home ranged from 10.4% in Canada to 55.4% in Mexico, while hospital deaths ranged from 41.8% in Mexico to 78.9% in South Korea. Controlling for age, sex, and marital status, patients with chronic obstructive pulmonary disease were significantly less likely die at home rather than in hospital in nine countries. Our study found in almost all countries that those dying from chronic obstructive pulmonary disease as compared with those from lung cancer are less likely to die at home and at a palliative care institution and more likely to die in a hospital or a nursing home. This might be due to less predictable disease trajectories and prognosis of death in chronic obstructive pulmonary disease.
Realizing universal quantum gates with topological bases in quantum-simulated superconducting chains
Authors: Hu Yong , Zhao Y. X. , Xue Zheng-Yuan , Wang Z. D. 
Published: February 2017

AbstractOne-dimensional time-reversal invariant topological superconducting wires of the symmetry class DIII exhibit exotic physics which can be exploited to realize the set of universal operations in topological quantum computing. However, the verification of DIII-class physics in conventional condensed matter materials is highly nontrivial due to realistic constraints. Here we propose a symmetry-protected hard-core boson simulator of the one-dimensional DIII topological superconductor. By using the developed dispersive dynamic modulation approach, not only the faithful simulation of this new type of spinful superconducting chains is achieved, but also a set of universal quantum gates can be realized with the computational basis formed by the degenerate ground states that are topologically protected against random local perturbations. Physical implementation of our scheme based on a Josephson quantum circuit is presented, where our detailed analysis pinpoints that this scheme is experimentally feasible with the state-of-the-art technology.
A novel CCR2 antagonist inhibits atherogenesis in apoE deficient mice by achieving high receptor occupancy
Authors: Bot Ilze , Ortiz Zacarías Natalia V. , de Witte Wilhelmus E. A. , de Vries Henk , van Santbrink Peter J. , van der Velden Daniël , Kröner Mara J. , van der Berg Dirk-Jan , Stamos Dean , de Lange Elizabeth C. M. , Kuiper Johan , IJzerman Adriaan P. , Heitman Laura H. 
Published: February 2017

AbstractCC Chemokine Receptor 2 (CCR2) and its endogenous ligand CCL2 are involved in a number of diseases, including atherosclerosis. Several CCR2 antagonists have been developed as potential therapeutic agents, however their in vivo clinical efficacy was limited. In this report, we aimed to determine whether 15a, an antagonist with a long residence time on the human CCR2, is effective in inhibiting the development of atherosclerosis in a mouse disease model. First, radioligand binding assays were performed to determine affinity and binding kinetics of 15a on murine CCR2. To assess the in vivo efficacy, western-type diet fed apoE−/− mice were treated daily with 15a or vehicle as control. Treatment with 15a reduced the amount of circulating CCR2+ monocytes and the size of the atherosclerotic plaques in both the carotid artery and the aortic root. We then showed that the long pharmacokinetic half-life of 15a combined with the high drug concentrations ensured prolonged CCR2 occupancy. These data render 15a a promising compound for drug development and confirms high receptor occupancy as a key parameter when targeting chemokine receptors.
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency – molecular profiling and functional rescue
Authors: Addis L. , Virdee J. K. , Vidler L. R. , Collier D. A. , Pal D. K. , Ursu D. 
Published: February 2017

AbstractMutations in the N-methyl-D-aspartate receptor (NMDAR) gene GRIN2A cause epilepsy-aphasia syndrome (EAS), a spectrum of epileptic, cognitive and language disorders. Using bioinformatic and patient data we shortlisted 10 diverse missense mutations for characterisation. We used high-throughput calcium-flux assays and patch clamp recordings of transiently transfected HEK-293 cells for electrophysiological characterization, and Western blotting and confocal imaging to assay expression and surface trafficking. Mutations P79R, C231Y, G483R and M705V caused a significant reduction in glutamate and glycine agonist potency, whilst D731N was non-responsive. These mutants, along with E714K, also showed significantly decreased total protein levels and trafficking to the cell surface, whilst C436R was not trafficked at all. Crucially this reduced surface expression did not cause the reduced agonist response. We were able to rescue the phenotype of P79R, C231Y, G483R and M705V after treatment with a GluN2A-selective positive allosteric modulator. With our methodology we were not able to identify any functional deficits in mutations I814T, D933N and N976S located between the glutamate-binding domain and C-terminus. We show GRIN2A mutations affect the expression and function of the receptor in different ways. Careful molecular profiling of patients will be essential for future effective personalised treatment options.