bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morse Taper Connection Implants Placed in Grafted Sinuses in 65 Patients: A Retrospective Clinical Study with 10 Years of Follow-Up
Authors: Mangano Francesco , Bakaj Renata , Frezzato Irene , Frezzato Alberto , Montini Sergio , Mangano Carlo 
Published: August 2017

Purpose. To investigate the 10-year survival and complication rates of Morse taper connection implants (MTCIs) placed in grafted sinuses.Methods. This study reports on patients treated with maxillary sinus augmentation (with the lateral window technique (LWT) or the transalveolar osteotomy technique (TOT)) and installed with MTCIs supporting fixed restorations (single crowns (SCs) and fixed partial dentures (FPDs)), in two dental clinics. The outcomes of the study were the 10-year implant survival and complication rates.Results. Sixty-five patients (30 males and 35 females) with a mean age of 62.7 (±10.2) years were installed with 142 MTCIs: 79 fixtures were inserted with the LWT and 63 were placed with the TOT. After ten years, five implants failed, for an overall survival rate of 96.5%. Three implants failed in the LWT group, for a survival rate of 96.3%; two implants failed in the TOT group, for a survival rate of 96.9%. The 10-year incidence of biologic complications was 11.9%. Prosthetic complications were all technical in nature and amounted to 7.6%.Conclusions. MTCIs seem to represent a successful procedure for the prosthetic restoration of the grafted posterior maxilla, in the long term. This study was registered in the ISRCTN registry with numberISRCTN30772506.
Validation of the DAPT score in patients randomized to 6 or 12 months clopidogrel after predominantly second-generation drug-eluting stents
Authors: Harada Yukinori , Michel Jonathan , Lohaus Raphaela , Mayer Katharina , Emmer Roberto , Lena Lahmann Anna , Colleran Roisin , Giacoppo Daniele , Wolk Annabelle , Berg Jurrien M. ten , Neumann Franz-Josef , Han Yaling , Adriaenssens Tom , Tölg Ralph , Seyfarth Melchior , Maeng Michael , Zrenner Bernhard , Jacobshagen Claudius , Wöhrle Jochen , Kufner Sebastian , Morath Tanja , Ibrahim Tareq , Bernlochner Isabell , Fischer Marcus , Schunkert Heribert , Laugwitz Karl-Ludwig , Mehilli Julinda , A. Byrne Robert , Kastrati Adnan , Schulz-Schüpke Stefanie 
Published: August 2017

SummaryThe DAPT score is a recently-proposed decision tool for guiding optimal duration of dual antiplatelet therapy (DAPT). It showed modest accuracy in prior derivation and validation cohorts of patients with ≥12 months DAPT. This study was aimed to evaluate the validity of the DAPT score in a cohort of patients with 6 or 12 months DAPT after implantation of predominantly second-generation drug-eluting stents. We analyzed data of patients enrolled in the ISAR-SAFE trial. Patients were classified into low (<2) or high (≥2) DAPT score groups. Primary ischaemic (all-cause death, myocardial infarction, definite stent thrombosis or stroke) and bleeding (TIMI major or minor) outcomes were analyzed in the low and high DAPT score groups. Data of 3976 patients were available for DAPT score calculation. 2407 patients (60.5%) were classified in the low DAPT score group and 1569 patients (39.5%) in the high DAPT score group. In the low DAPT score group there were no significant differences between 6 and 12 months DAPT regarding ischaemic (1.0% vs. 1.4%, HR=0.74, 95% CI, 0.35–1.57; p=0.43) or bleeding outcomes (0.3% vs. 0.8%, HR=0.44, 95% CI, 0.13–1.42; p=0.17). In the high DAPT score group there were also no significant differences between 6 and 12 months DAPT regarding ischaemic (1.9% vs. 1.8%, HR=1.02, 95% CI, 0.49–2.14; p=0.96) or bleeding (0.3% vs. 0.5%, HR=0.51, 95% CI, 0.09–2.78; p=0.44) outcomes. In conclusion, the DAPT score failed to show a differential treatment effect in patients receiving 6 or 12 months DAPT after contemporary drug-eluting stent implantation.
Errors Using Observational Methods for Ergonomics Assessment in Real Practice
Authors: Diego-Mas Jose-Antonio , Alcaide-Marzal Jorge , Poveda-Bautista Rocio 
Published: August 2017

Objective: The degree in which practitioners use the observational methods for musculoskeletal disorder risks assessment correctly was evaluated. Background: Ergonomics assessment is a key issue for the prevention and reduction of work-related musculoskeletal disorders in workplaces. Observational assessment methods appear to be better matched to the needs of practitioners than direct measurement methods, and for this reason, they are the most widely used techniques in real work situations. Despite the simplicity of observational methods, those responsible for assessing risks using these techniques should have some experience and know-how in order to be able to use them correctly. Method: We analyzed 442 risk assessments of actual jobs carried out by 290 professionals from 20 countries to determine their reliability. Results: The results show that approximately 30% of the assessments performed by practitioners had errors. In 13% of the assessments, the errors were severe and completely invalidated the results of the evaluation. Conclusion: Despite the simplicity of observational method, approximately 1 out of 3 assessments conducted by practitioners in actual work situations do not adequately evaluate the level of potential musculoskeletal disorder risks. Application: This study reveals a problem that suggests greater effort is needed to ensure that practitioners possess better knowledge of the techniques used to assess work-related musculoskeletal disorder risks and that laws and regulations should be stricter as regards qualifications and skills required by professionals.
Emergency department presentations of people who are homeless: The role of occupational therapy
Authors: Lloyd Chris , Hilder Joanne , Williams Philip Lee 
Published: August 2017

Introduction This project had two aims: to gain an understanding of the profile and expressed needs of people seen by the Homeless Emergency Department Liaison Officer in the emergency department in comparison to general hospital presentations, and to explore the potential role for occupational therapy to respond to this population. Method The Emergency Department Information Systems database and Homeless Emergency Department Liaison Officer files were examined to gather data on all individuals who presented to the hospital emergency department over a 16-month period. The viability of a discipline-specific role to respond to this population was then considered by senior occupational therapists. Results The results revealed that the majority of homeless people seen were male and in the early middle age group, with more than half arriving at the emergency department by way of ambulance services. The most common reasons for presentation were medical, mental health and drug- and alcohol-related issues. Conclusion It was found that a large percentage of people seen in the emergency department were discharged back to the streets. Senior occupational therapists have the potential to provide brief assessments and interventions that could reduce the ongoing demand on emergency department resources by people who are homeless.
Global loss of myelin water over 5 years in multiple sclerosis normal-appearing white matter
Authors: Vavasour Irene M , Huijskens Sophie C , Li David KB , Traboulsee Anthony L , Mädler Burkhard , Kolind Shannon H , Rauscher Alexander , Moore GR Wayne , MacKay Alex L , Laule Cornelia 
Published: August 2017

Background: Reduced myelin water fraction (MWF, a marker for myelin), increased geometric mean T2 (ieGMT2, reflecting intra/extracellular water properties), and increased T1 (related to total water content) have been observed in cross-sectional studies of multiple sclerosis (MS) normal-appearing white matter (NAWM). Objective: To assess longitudinal changes of magnetic resonance (MR) measures in relapsing-remitting MS (RRMS) brain NAWM. Methods: A total of 11 subjects with RRMS and 4 controls were scanned on a 3T MRI at baseline and long-term follow-up (LTFU; 3.2–5.8 years) with a 32-echo T2 relaxation and an inversion recovery T1 sequence. For every voxel, MWF, ieGMT2, and T1 were obtained. Mean, peak height, and peak location from NAWM mask-based histograms were determined. Results: In MS subjects, NAWM MWF mean decreased by 8% ( p = 0.0016). No longitudinal changes were measured in T1 or ieGMT2. There was no relationship between change in any MR metric and change in EDSS. Control white matter showed no differences over time in any metric. Conclusion: The decreases we observed in MWF suggest that changes in myelin integrity and loss of myelin may be occurring diffusely and over long time periods in the MS brain. The timescale of these changes indicates that chronic, progressive myelin damage is an evolving process occurring over many years.
Transtibial Versus Anteromedial Portal ACL Reconstruction: Is a Hybrid Approach the Best?
Authors: Jennings Jonathan K. , Leas Daniel P. , Fleischli James E. , D’Alessandro Donald F. , Peindl Richard D. , Piasecki Dana P. 
Published: August 2017

Background: Improved biomechanical and clinical outcomes are seen when the femoral tunnels of the anterior cruciate ligament (ACL) are placed in the center of the femoral insertion. The transtibial (TT) technique has been shown to be less capable of this than an anteromedial (AM) portal approach but is more familiar to surgeons and less technically challenging. A hybrid transtibial (HTT) technique using medial portal guidance of a transtibial guide wire without knee hyperflexion may offer anatomic tunnel placement while maintaining the relative ease of a TT technique. Purpose: To evaluate the anatomic and biomechanical performance of the HTT technique compared with TT and AM approaches. Study Design: Controlled laboratory study. Methods: Thirty-six paired, fresh-frozen human knees were used. Twenty-four knees (12 pairs) underwent all 3 techniques (TT, AM, HTT) for femoral tunnel placement, with direct measurement of femoral insertional overlap and femoral tunnel length. The remaining 12 knees (6 pairs) underwent completed reconstructions to evaluate graft anisometry and tunnel orientation, with each technique performed in 4 specimens and tested using motion sensors with a quad-load induced model. Graft length changes and graft/femoral tunnel angle were measured at varying degrees of flexion. Results: Percentage overlap of the femoral insertion averaged 37.0% ± 28.6% for TT, 93.9% ± 5.6% for HTT, and 79.7% ± 7.7% for AM, with HTT significantly greater than both TT ( P = .007) and AM ( P = .001) approaches. Graft length change during knee flexion (anisometry) was 30.1% for HTT, 12.8% for AM, and 8.5% for TT. When compared with the TT approach, HTT constructs exhibited comparable graft–femoral tunnel angulation (TT, 150° ± 3° vs HTT, 142° ± 2.3°; P < .001) and length (TT, 42.6 ± 2.8 mm vs HTT, 38.5 ± 2.0 mm; P = .12), while AM portal tunnels were significantly shorter (31.6 ± 1.6 mm; P = .001) and more angulated (121° ± 6.5°; P < .001). Conclusion: The HTT technique avoids hyperflexion and maintains femoral tunnel orientation and length, similar to the TT technique, but simultaneously achieves anatomic graft positioning. Clinical Relevance: The HTT technique offers an anatomic alternative to an AM portal approach while maintaining the technical advantages of a traditional TT reconstruction.
Epileptic Negative Myoclonus as the First and Only Symptom in a Challenging Diagnosis of Benign Epilepsy With Centrotemporal Spikes
Authors: Chen Jing , Zheng Guo , Guo Hu , Lu Xiaopeng , Wu Chunfeng , Wang Xiaoyu , Tao Wei 
Published: August 2017

Objective: To investigate the clinical and neurophysiological characteristics of epileptic negative myoclonus as the first and only ictal symptom of benign epilepsy with centrotemporal spikes. Methods: Electrophysiological evaluations included polygraphic recordings with simultaneous video electroencephalogram monitoring and tests performed with patient’s upper limb outstretched in standing posture. Epileptic negative myoclonus manifestations, electrophysiological features, and responses to antiepileptic drugs were analyzed. Results: The authors report 2 patients with benign epilepsy with centrotemporal spikes, who had epileptic negative myoclonus as the first and only seizure type. Video electroencephalogram monitoring results showed that their negative myoclonus seizures were emanating from the contralateral central and the parietal regions. Epileptic negative myoclonus was controlled by administration of valproate and levetiracetam. Conclusion: Epileptic negative myoclonus can be the first and only seizure type of benign epilepsy with centrotemporal spikes, and long-term follow-up monitoring should be the care for the recurrence and/or presence of other types of seizures.
Akt/FoxM1 signaling pathway-mediated upregulation of MYBL2 promotes progression of human glioma
Authors: Zhang Xue , LV Qiao-Li , Huang Yuan-Tao , Zhang Li-Hua , Zhou Hong-Hao 
Published: August 2017

Abstract
Background
MYB-related protein B (B-MYB/MYBL2), a member of the myeloblastosis family of transcription factors, has been reported for its role in the genesis and progression of tumors. Forkhead box M1 (FoxM1), another transcriptional factor, is considered to be an independent predictor of poor survival in many solid cancers. The aim of the present study was to investigate the clinical significance of the correlation between MYBL2 and FoxM1 in glioma and the possible mechanism of FoxM1and MYBL2 expression.

Methods
MYBL2 and FoxM1expression in cancerous tissues and cell lines were determined by reverse transcription-PCR (RT-PCR), Western blotting and immunostaining. The co-expression of MYBL2 and FoxM1 was analyzed in low-grade glioma (LGG) and glioblastoma (HGG) cohorts of TCGA using cBioportal and UCSC Xena. And, the role of MYBL2 and FoxM1 in glioma cell progression and the underlying mechanisms were studied by using small interfering RNA (si-RNA) and pcDNA3.1 + HAvectors. Furthermore, the effects of MYBL2 and FoxM1 in cell proliferation, cell cycle progression, apoptosis, migration, invasion, and adhesion were determined by cell proliferation assays, flow cytometry analysis, transwell migration and cell adhesion assay.

Results
MYBL2 and FoxM1 expression are significantly associated with clinical stages and overall survival of glioma patients. In cohorts of TCGA, patients with high MYBL2 but without radio-chemotherapy had the highest hazard ratio (adjusted HR = 5.29, 95% CI = 1.475–18.969, P < 0.05). Meanwhile, MYBL2 closely related to the FoxM1 expression in 79 glioma tissues (r = 0.742, p < 0.05) and LGG (r = 0.83) and HGG (r = 0.74) cohorts of TCGA. Down regulation of FoxM1 and MYBL2 by siRNAs induced the cell cycle arrest, apoptosis and EMT of glioma cells. Furthermore, inactivations of Akt/FoxM1 signaling by Akt inhibitor and siRNA-FoxM1 reduce the expression of MYBL2 in glioma cells.

Conclusions
MYBL2 is a key downstream factor of Akt/FoxM1 signaling to promote progression of human glioma, and could be a new candidate gene for molecular targeting therapy and biomarker for radiotherapy of glioma.

Trial registration
CTXY-1300041-3-2. ChiCTR-COC-15006186. Registered date: 13 September 2013.
What is the impact of innovation on output in healthcare with a special focus on treatment innovations in radiotherapy? A literature review
Authors: Jacobs Maria , Boersma Liesbeth , Dekker Andre , Swart Rachelle , Lambin Philippe , de Ruysscher Dirk , Verhaegen Frank , Stultiens Joost , Ramaekers Bram , van Merode Frits 
Published: August 2017

Objective:
To analyse how often innovations in healthcare are evaluated regarding output, especially in radiotherapy. Output was defined as either survival, toxicity, safety, service, efficiency or cost-effectiveness.

Methods:
A systematic literature review was conducted, using three search strategies: (1) innovations in general healthcare; (2) radiotherapy-specific innovations, i.e. organizational innovations and general implementation of innovations; (3) innovations per tumour group/radiotherapy technique. Scientific levels were classified according to the system used in European Society for Medical Oncology guidelines. Finally, we calculated the percentage of implemented innovations in Dutch radiotherapy centres for which we found evidence regarding output in the literature review.

Results:
Only 94/1072 unique articles matched the inclusion criteria. Significant results on patient outcome, service or safety were reported in 65% of papers, which rose to 76% if confined to radiotherapy reviews. A significant technological improvement was identified in 26%, cost-effectiveness in 10% and costs/efficiency in 36% of the papers. The scientific level of organizational innovations was lower than that of clinical papers. Dutch radiotherapy treatment innovations were adequately evaluated on outcome data before implementation in clinical routine in a minimum of 64–92% of cases.

Conclusion:
Only few studies report on output when considering innovations in general, but radiotherapy reviews give a reasonably good insight into innovation output effects, with a higher level of evidence. In Dutch radiotherapy centres only small improvements are possible regarding evaluation of treatment innovations before implementation.

Advances in knowledge:
This study is the first of its kind measuring how innovations are evaluated in scientific literature, before implementation in clinical practice.
The significance of some growth factors in the pathogenesis of endocrine ophthalmopathy
Authors: Charinzev Vladimir V. , Serkin Dmitriy M. , Serebryakova Olga V. , Charinzeva Svetlana V. 
Published: August 2017

Aim. The purpose of this work was to study the role of transforming growth factors (TGF-β, FGF-2, VEGF-A) during endocrine ophthalmopathy (EOC).
Materials and methods. The study 119 patients with endocrine ophthalmopathy were examined, at the age of 48 [30; 56] years. There were 56 men (47%). The comparison groups were control group (Control) - 20 practically healthy persons, comparison group (Comparison group) - 20 patients with autoimmune pathology of the thyroid gland without EOC. All groups were comparable by sex and age. The object of the study was serum and tear fluid. To quantify the transforming growth factors (TGF-β, FGF-2, VEGF-A) in the blood and tear fluid, the enzyme immunoassay kit was used by Biokhimmak LLC. The severity of the disease was exhibited according to the current classification. The statistical processing of the obtained data was carried out using the program Statistica 6.1.
Results. An increase in the concentration of all growth factors in blood serum and tear fluid was found in patients with endocrine ophthalmopathy, compared with a group of healthy individuals. It was noted that in the lacrimal fluid the increase in the concentration of the growth factors studied was associated with the severity of the disease and the activity of the process. The multidirectional dynamics of the content of the vascular endothelial growth factor was established, so the maximum value in the blood serum was determined in patients with mild severity in an inactive form, in the tear the highest rates were recorded in severe form of the active disease.
Conclusion. In patients with endocrine ophthalmopathy, the concentration of FGF-2 and TGF-β in the blood serum and tear increased to a greater extent in severe forms of the disease in the active phase. The maximum concentrations of FGF-2 and TGF-β in the serum and tear, VEGF-A in the tear are fixed in the active phase of the severe form of the endocrine ophthalmopathy. The results obtained allow us to regard FGF-2, TGF-β and VEGF-A as biological markers of gravity and endocrine ophthalmopathy activity.
Espacio de Formación Integral “Agricultura familiar en el Uruguay”. Propuesta de formación para el análisis crítico de la ruralidad uruguaya
Authors: Carámbula Pareja Matías , Fernández Rondoni Emilio 
Published: August 2017

La Universidad de la República (UdelaR) de Uruguay ha iniciado un proceso de reforma que, entre otros objetivos, busca mejorar la integralidad de las funcionesuniversitarias. Una de las propuestas para fomentar la integración de actividades de enseñanza, investigación y extensión, es la promoción de los Espacios de Formación Integral (EFI). El EFI “Agricultura familiar en el Uruguay” es una propuesta formativa en la cual se articula un espacio de formación conceptual con un trabajo empírico de aproximación a la realidad, las dinámicas y las estrategiasde los agricultores familiares del Uruguay. A lo largo del tiempo se ha generado una diversidad de productos (artículos, ponencias, proyectos, tesis, grupos detrabajo) pero, sin dudas, la experiencia acumulada da cuenta que el principal resultado es una nueva forma de enseñar y aprender en sintonía con algunos de los sectores postergados del campo.
Desafíos de la Educación Alimentaria Nutricional: construcción de espacios y vínculos en el nivel inicial
Authors: Ravelli Sandra , Panicia Adriana , Figueroa Érica 
Published: August 2017

Este artículo describe las intervenciones que se realizaron en el marco de un Proyecto de Extensión en Educación Experiencial de la Universidad Nacional del Litoral. La misma convocó a los alumnos avanzados que realizan las prácticas profesionales de la Licenciatura en Nutrición de la Facultad de Bioquímica y Ciencias Biológicas. El proyecto tiene por objeto la promoción de una alimentación saludable a través de propuestas didácticas y lúdicas e involucra diferentes ejes: sobre alimentación saludable e higiene de manos y de los alimentos en el nivel inicial.El artículo abordará las tres etapas que insumió el proyecto: capacitación y vinculación de los agentes (equipo extensionista, docentes, no docentes, alumnos de prácticas profesionales y familias), construcción de recursos didácticos con contenidos de nutrición y paralelamente una etapa de interacción e implementación de las actividades con la comunidad. Asimismo, se dará cuenta de los logros y dificultades que implicó su desarrollo.
Vigilancia nutricional en escolares de la ciudad de Santa Fe: educación experiencial con estudiantes de Licenciatura en Nutrición
Authors: Dezar Gimena , Kruger Ana Luz 
Published: August 2017

El presente trabajo relata la experiencia de una propuesta de práctica de extensión de educación experiencial desarrollada por alumnas de 3º año de la carrera de Licenciatura en Nutrición de la Universidad Nacional del Litoral (UNL).Además, participaron el equipo docente de la cátedra de Epidemiología y Salud Pública, tutores, docentes y directivos de nueve escuelas primarias de la ciudadde Santa Fe, niños y niñas de esas instituciones, sus padres y familias. Desde el equipo docente se viene trabajando en extensión, integrándola con la docencia y la investigación, haciendo hincapié en problemas nutricionales que ocurren en la niñez. En esta dirección, y en concordancia con lo planteado desde la UNL, se intenta contribuir de manera significativa a una mejor calidad y pertinenciauniversitaria, participando en los procesos de enseñanza y aprendizaje, en la generación de nuevos conocimientos y en la apropiación social de los mismos