bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathways Clinical Decision Support for Appropriate Use of Key Biomarkers
Authors: Ellis Peter G. , Brufsky Adam M. , Beriwal Sushil , Lokay Kathleen G. , Benson Hans O. , McCutcheon Stephanie B. , Krebs Melinda 
Published: June 2016

Purpose: Breast cancer diagnostics have the ability to predict disease recurrence and the benefit of chemotherapy. This study measures the use of a diagnostic assay, Oncotype DX, when embedded in a breast cancer decision support algorithm and, on the basis of the assay results, the use of chemotherapy in the adjuvant setting. Methods: UPMC CancerCenter retrospectively reviewed patients with estrogen receptor–positive, human epidermal growth factor receptor 2 (HER2)Neu–negative disease with zero to three positive nodes navigated in the Via Pathways decision support portal during a 12-month period. The breast algorithm prompted input of the assay recurrence score (RS) and then recommended hormonal therapy alone (HT) for low RS, or chemotherapy followed by HT for high RS. The patient’s RS was correlated with the treatment decision. Results: During this time period, 643 patients had ER-positive, HER2Neu-negative disease with zero to three positive nodes. Of those, 596 (92.7%) had diagnostic testing to determine chemotherapy plus HT versus HT alone, and 47 had chemotherapy followed by HT without an RS. For node-negative patients classified with low or high RS, pathway treatment adherence rates were 99.7% and 96.6%, respectively; node-positive patients had 95.7% and 87.5% adherence rates, respectively. Conclusion: This analysis demonstrates the use of a clinical pathway to measure the adoption of a diagnostic test, the Oncotype DX breast assay, and the use of the appropriate therapy on the basis of the RS. As more diagnostics are established to aid in the personalized treatment of diseases, pathways may be important in maintaining clinician awareness of the appropriate disease presentations where these tests should be used, measuring usage of these tests, and tracking the treatment decisions on the basis of test results.
Clinical Benefits Associated With Medicaid Coverage Before Diagnosis of Gynecologic Cancers
Authors: Doll Kemi M. , Basch Ethan M. , Meng Ke , Barber Emma L. , Gehrig Paola A. , Brewster Wendy R. , Meyer Anne-Marie 
Published: June 2016

Purpose:Many low-income patients enroll in Medicaid at the time of cancer diagnosis, which improves survival outcomes. Medicaid enrollment before cancer diagnosis may confer additional benefits. Our objective was to compare stage at diagnosis and overall mortality between women with and without Medicaid enrollment before gynecologic cancer diagnosis.Methods and Materials:Women younger than 65 years with a gynecologic cancer (2003 to 2008) were identified through the North Carolina Central Cancer Registry and linked to state Medicaid enrollment files. Those with and without Medicaid enrollment within 6 months before diagnosis were identified. Propensity matching was used to balance the exposure groups. Stage at diagnosis was evaluated by using logistic regression, and all-cause mortality was assessed with Cox proportional hazard models.Results:Of 564 women, one half (n = 282) had prediagnosis Medicaid enrollment. Disease sites included the cervix (44%), uterus (25%), ovary (26%), and vulva/vagina (5%). More than one half (51%) of cancers were advanced stage. Women without prediagnosis Medicaid had an increased odds of advanced-stage disease (hazard ratio, 1.46; 95% CI, 1.03 to 2.05). Crude survival outcomes differed significantly between the groups; however, when adjusted for stage at diagnosis, lack of prediagnosis Medicaid coverage had a hazard ratio of 1.19 (95% CI, 0.92 to 1.53).Conclusion:Medicaid enrollment before gynecologic cancer diagnosis is associated with an earlier stage at presentation. Given the existence of a cervical cancer screening program in North Carolina and lack of Medicaid expansion, these data suggest that screening programs alone are not sufficient to counteract the delay in diagnosis that is common for uninsured individuals.
pH Control in a Urease-catalyzed Reaction Using Weak-base Beads as Polymer-supported Buffer Agents
Authors: Li Wenzhao , Li Yongsheng , Yang Zhiqiang , Xu Chunhua 
Published: June 2016

Abstract
To reduce phosphorus waste water from phosphate buffers, we utilized weak-base beads as eco-friendly and reusable buffer agents for the pH control of urease-catalyzed reactions.
A atividade física voluntária e seus efeitos sobre a neurogênese hipocampal em roedores adultos – Uma revisão de literatura
Authors: Bavaresco Anelise 
Published: June 2016

Esta revisão objetivou sistematizar as informações sobre a atividade física voluntária em roda de correr e sua relação com a neurogênese hipocampal na fase adulta. A pesquisa foi realizada na base de dados eletrônica US National Library of Medicine (PubMED). Foram incluídos artigos originais que abordassem o uso de roedores e a corrida voluntária como modelo de exercício; que relatassem a ocorrência de neurogênese hipocampal na fase adulta; publicados nos últimos cinco anos; disponíveis na íntegra; em inglês ou português. Foram excluídos: artigos de revisão; que abordassem a neurogênese humana; que se utilizassem de outros modelos de exercício físico; que não obedecessem aos critérios de inclusão. A busca eletrônica identificou 28 artigos relevantes, dos quais três não analisaram a ocorrência de neurogênese hipocampal e três não avaliaram a ocorrência da neurogênese na fase adulta, sendo então excluídos e restando 22 publicações. Os estudos avaliaram um total de 16 espécies diferentes de roedores, com predominância da linhagem de camundongos C57BL/6. O tempo de exposição à roda de corrida variou entre três dias e seis meses. Em conclusão, fatores como diferenças genéticas, neurotrofinas e a relação com o desenvolvimento de um comportamento ansioso interferem na expressão da neurogênese hipocampal na fase adulta após a atividade física voluntária. Essas evidências servem para nortear novos estudos a fim de melhor elucidar os mecanismos pelos quais esses fenômenos ocorrem, contudo, é indubitável o benefício que a prática regular de exercício físico, pode trazer aos indivíduos com neuropatologias.
Midwives' experiences of helping women struggling to breastfeed
Authors: Lawton Kath 
Published: June 2016

Background: Breastfeeding is accepted as the optimum way to nourish babies. It is established that women need informed support from midwives, but the focus of previous research has been predominantly on women's experiences, rather than that of midwives. Aims: The aim of this study was to explore midwives' experiences of helping women who were struggling to breastfeed. Methods: A qualitative methodology was selected using a phenomenological approach. Some 5 midwives were purposefully recruited and data was collected using semi-structured interviews. Following transcription, data was analysed using Colaizzi's (1978) framework of analysis. Findings: Three themes emerged describing midwives' experiences: time poverty, the impact of being ‘with women’, and professional integrity. Conclusions: The study revealed that breastfeeding has an emotional impact on midwives. Not being able to spend the time they felt the women needed affected the midwives. With reports of an increasing shortage of midwives, there is concern that time poverty may increase, leading to a greater sense of professional dissatisfaction.
McDonaldisation: does it affect you as an HCA or AP?
Authors: Mobeen Junaid , Hayes Catherine , Fulton John 
Published: June 2016

Establishing the factors resultant from the regulation of healthcare assistant (HCA) practice will be the ongoing focus of research for several years. One of the most obvious, from a sociological perspective, is the concept of ‘McDonaldisation’. Since bureaucratic management styles dominate in the National Health Service (NHS), there is relevance to considering the impact of the theory to practice for HCAs, at a time of distinct strategic and emergent change for the role of the HCA in relation to political and legislative drivers, such as the Care Certificate. This article makes accessible and explores the impact of McDonaldisation on the role of the HCA and the identity of this huge sector of the healthcare workforce in hospital and community settings. By presenting both positive and negative aspects of McDonaldisation, core recommendations are made, based on the potential of HCAs as an often undervalued and overlooked sector of the healthcare sector to further develop. The article first outlines what McDonaldisation is, for those HCAs who may not be familiar with the term, and encourages reasoned debate about what bureaucracy and change might potentially mean in practice, in terms of positive and negative impact. The article concludes with recommendations for the implementation of McDonaldisation, where possible positive impacts can be identified. It provides a critical lens for HCAs in circumstances where McDonaldisation could have a potentially negative or constraining impact on HCA practice.
Reconsideration of iodine in wound irrigation: the effects on Pseudomonas aeruginosa biofilm formation
Authors: Kanno E. , Tanno H. , Suzuki A. , Kamimatsuno R. , Tachi M. 
Published: June 2016

Objective: Chronic skin wounds are usually colonised with bacteria and subsequent infection may develop. Topical antiseptics are commonly used to control bacterial colonisation. The topical antiseptic, 1% polyvinylpyrrolidone-iodine (PVP-I), that is used on chronic open skin wounds remains controversial in the clinical setting because of its cytotoxicity. Here, we tested 1% PVP-I solution against saline to determine if it reduces bacterial count on the wound surface and within the tissue that may lead to wound reduction. Method: Open wounds that were created on the backs of Sprague Dawley rats were inoculated with Pseudomonas aeruginosa at the wound surface. Wounds were kept covered except for wound irrigation, two days post-wounding, wounds were irrigated daily using a 10ml syringe and spray tip. Results: Our results indicate that 1% PVP-I irrigation resulted in a reduced bacterial count on the wound surface and within the tissue compared with saline irrigation. The 1% PVP-I irrigation promoted wound re-epithelialisation compared with saline irrigation, but it did not reach significance. Conclusion: These results indicated that irrigation with 1% PVP-I was an effective way to reduce bacterial count on the wound surface, and allow the wound to progress to healing. Declaration of interest: This work was supported in part by a Grant-in-aid for Scientific Research (B) (21390476) and a Grant-in-aid for Scientific Research (C) (25463284) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The authors state no financial conflict of interest.
Novel biodegradable hydrogel sponge containing curcumin and honey for wound healing
Authors: Momin M. , Kurhade S. , Khanekar P. , Mhatre S. 
Published: June 2016

Objective: To develop and evaluate a biodegradable superporous hydrogel based wound healing composite of chitosan and alginate incorporated with curcumin and honey. Method: A 32 factorial design was adopted to optimise the honey-curcumin hydrogel composite sponge (CHS). Sodium alginate and chitosan were dissolved in deionised water and 1% aqueous acetic acid solution at room temperature, respectively. Ethanolic solution of curcumin was poured into the chitosan solution followed by an addition of sodium alginate solution. In situ polymerisation was carried out by adding acrylamide base components to the polymeric solution of curcumin. Finally, honey was added with slow stirring and a sponge was cast on a glass surface by solvent evaporation at 45ºC. The produced sponge was assessed for swelling capacity, moisture loss, tensile strength, biocompatibility, bioadhesion, biodegradation, drug diffusion and wound healing properties. The morphology of CHS was studied by scanning electron microscopy (SEM). Results: The optimised CHS demonstrated a high swelling capacity (111.05 ± 05%), tensile strength (4323gm/mm2 ), in vitro drug diffusion (75.03 ± 3.59%/20days), bioadhesion (20 ± 0.2mg force) and ability of water vapour transmission. A rapid induction of tissue granulation and re-epithelialisation was observed. Time to complete healing (94.14 ± 1.04% wound contraction) was 7 ± 2 days. Conclusion: This study has shown that honey-curcumin hydrogel composite sponge can be formulated by a simple mixing and in situ polymerisation method. The hydrogel base provided a dry wound bed due to excellent fluid absorption capacity. Chitosan and honey contributed to effective faster wound healing. We recommend further clinical studies of the soft sponge wound healing composite for diabetic foot or pressure ulcers. Declaration of interest: The authors have no conflict of interest to declare.
Research roundup: June 2016
Authors: Greener Mark 
Published: June 2016

In brief The UK probably underestimates the prevalence of medical errors, which might now be the third leading cause of death in the USA Prescriptions for attention deficit hyperactivity disorder drugs increased by almost 800% between 2000 and 2015 Varenicline and bupropion do not seem to increase the risk of neuropsychiatric adverse events compared to nicotine patches or placebo; varenicline is more effective at helping patients quit than placebo, nicotine patches and bupropion Some studies associate sulfonylureas with cardiovascular events, but a new meta-analysis is reassuring
Alive or dead? Face to face with contemporary dance
Authors: Claid Emilyn 
Published: June 2016

Abstract
At a time when artists are questioning twenty-first-century dance for its contemporary-ness, this writing exposes a tension that plays across differing choreographic processes – a tension that suggests a widening rift between letting go into collaborative uncertainty and the creation of single authored productions of spectacle. I suggest that a move away from spectacle in the United Kingdom is exacerbated by various wider themes such as practice as research, somatics, digital technology and neo-liberalism, all of which have deeply affected artists’ performance processes. Particular emphasis is given to how shifts in institutionally driven dance training and education are affecting performance, and the writing draws attention to what artists might have in common across the divide – a passionate engagement with how we communicate what we do with others.
Centralised Biological Therapy Registry for Moderate to Severe Plaque Psoriasis – Overview and Methodology
Authors: Sutka R , Pec J , Pecova T 
Published: June 2016

Abstract
The introduction of new pharmacotherapy entities in the last decade accentuate the necessity to set up treatment guidelines based on real life evidence. Randomized controlled trials remain golden standard of a research. Data derived from studies aiming on daily clinical practice should bring needed, added value. Disease prevalence growth, due to increased life expectancy, better diagnostic procedures and earlier medical intervention, as well as ever growing demand for highly priced, sophistically produced drugs put stress on healthcare budgets even in developed countries. Large databases commonly called - therapy registries are implemented to collect data on therapy effectivity in terms of effectiveness, safety and patient long-term on therapy survival. Registries importance rose together with biological therapies introduction. New in class molecules entered the market conditionally being obliged to provide additional e.g. safety data. Such procedures require involvement of many different professionals, e.g. physicians, professional medical bodies, IT experts, database administrators, statisticians and government institutions. Paper based, followed by computer based forms were distributed among physicians to collect these data. eHealth technologies provide physicians with centralized, more intuitive applications. The particularities of different diagnosis caused great variations within each specific registry launched. Important information was missing since they were pointed out as optional and many were redundant causing frustration among physicians due to inadequate administrative workload. The main objective of this work was to set up the therapy registry standards and procedures. Methodology of „ideal“ moderate to severe plaque psoriasis biology therapy registry development, introduction, administration and evaluation was prepared to assist any government institution or professional body when planning registry deployment. Electronic application based on widely used MS Excel platform was developed and installed in the biological therapy centers as a standalone application for the pilot use.
Theoretical study of substituent effects on the geometry and strain enthalpy in [2,2]paracyclophanes
Authors: Michalík Martin , Poliak Peter , Lukeš Vladimír 
Published: June 2016

Abstract
The substituent effect on the geometry and strain enthalpy of [2,2]paracyclophane is theoretically investigated by density functional theory. Gas-phase calculations were performed for twenty distinct electron donating and electron withdrawing substituents. The largest out-of-plane distortion of phenyl rings is exhibited by —SCN and —CF3 groups. On the other hand, —OH, —CH3 and —F groups show the minimal deformation. The strain enthalpy for unsubstituted [2,2]paracyclophane associated with repulsive forces between phenyl units reached up to 118.5 kJ mol−1. Any substitution causes increase of the strain enthalpy value proportionally to the absolute values of Hammett para-substituent constants. Two separate linear dependences with similar slopes were obtained for monosubstituted as well as double symmetrically substituted derivatives.
Heavy metals determination using various in situ bismuth film modified carbon-based electrodes
Authors: Sochr Jozef , Machková Martina , Machyňák Ľubomír , Čacho František , Švorc Ľubomír 
Published: June 2016

Abstract
The proposed work deals with the utilization of three carbon-based electrode substrates such as boron-doped diamond, glassy carbon and carbon paste for the preparation of in situ bismuth film modified electrodes. Such modified electrodes were subsequently used for the differential pulse anodic stripping voltammetric determination of heavy metal cations (Zn2+, Cd2+ and Pb2+) individually and simultaneously using similar experimental conditions (0.1 mol l−1 acetic buffer solution of pH 4.5 as supporting electrolyte with the addition of 0.1 mmol l−1 Bi3+, deposition potential of −1.4 V and deposition time of 120 s). The results showed that the modification step mostly enhanced the deposition and stripping process of studied cations when compared to the bare electrode substrates. A boron-doped diamond electrode was selected as the substrate for modification and the procedure was applied to the real sample analysis including water sample (certified reference material) and wastewater sample. Using the standard addition method the concentrations of particular heavy metals were quantified and the determined values were in a good agreement with those obtained by the reference method — high resolution atomic absorption spectroscopy with electrothermal atomisation and continual radiation source. This fact highlights that the developed in situ bismuth film modified boron-doped diamond electrode is a suitable electrochemical sensor to be applied to routine analysis of water samples containing heavy metals.
Immobilization of urease enzyme on nanoceria modifies secondary and tertiary protein structures
Authors: Al-Hakeim Hussein Kadhem , Khudhair Muneer Kadhem , Grulke Eric Anderson 
Published: June 2016

Abstract
Urease catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. The increase in pH from the urease reaction causes a broad range of deleterious effects. Nanoceria (cerium oxide) possesses unique chemical properties under a redox reaction. This study investigated the synthesis of nanoceria via a hydrothermal method and determined its interaction with urease enzyme.
Transmission electron microscopy results showed a cubic-figured nanoceria with a size of ~15 nm. Urease was immobilized on nanoceria through adsorption. The maximum velocity (V
max) and Michaelis constant (K
m) of the free urease and urease immobilized on nanoceria decreased after interaction with nanoceria, and the Lineweaver-Burk plot showed an uncompetitive inhibition. The thermodynamic study of the adsorption process showed an endothermic reaction. The interaction changed the secondary and tertiary structures of urease as demonstrated by the circular dichroism study (the decrease in both α- and β-structure percentages). The fluorescence study revealed a change in the tertiary structure. The FTIR for the nanoceria—urease complex showed no changes in the covalent bonds, which indicated the involvement of physical forces in the interaction between urease and nanoceria.
Comparing Transformation Possibilities of Topological Functioning Model and BPMN in the Context of Model Driven Architecture
Authors: Solomencevs Artūrs 
Published: June 2016

Abstract
The approach called “Topological Functioning Model for Software Engineering” (TFM4SE) applies the Topological Functioning Model (TFM) for modelling the business system in the context of Model Driven Architecture. TFM is a mathematically formal computation independent model (CIM). TFM4SE is compared to an approach that uses BPMN as a CIM. The comparison focuses on CIM modelling and on transformation to UML Sequence diagram on the platform independent (PIM) level. The results show the advantages and drawbacks the formalism of TFM brings into the development.
Introduction to Lean Canvas Transformation Models and Metrics in Software Testing
Authors: Nidagundi Padmaraj , Novickis Leonids 
Published: June 2016

Abstract
Software plays a key role nowadays in all fields, from simple up to cutting-edge technologies and most of technology devices now work on software. Software development verification and validation have become very important to produce the high quality software according to business stakeholder requirements. Different software development methodologies have given a new dimension for software testing. In traditional waterfall software development software testing has approached the end point and begins with resource planning, a test plan is designed and test criteria are defined for acceptance testing. In this process most of test plan is well documented and it leads towards the time-consuming processes. For the modern software development methodology such as agile where long test processes and documentations are not followed strictly due to small iteration of software development and testing, lean canvas transformation models can be a solution. This paper provides a new dimension to find out the possibilities of adopting the lean transformation models and metrics in the software test plan to simplify the test process for further use of these test metrics on canvas.