bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compromised Neurocircuitry in Chronic Blast‐Related Mild Traumatic Brain Injury
Authors: Yeh Ping‐Hong , Guan Koay Cheng , Wang Binquan , Morissette John , Sham Elyssa , Senseney Justin , Joy David , Kubli Alex , Yeh Chen‐Haur , Eskay Victora , Liu Wei , French Louis M. , Oakes Terrence R. , Riedy Gerard , Ollinger John 
Published: September 2016

AbstractThe aim of this study was to apply recently developed automated fiber segmentation and quantification methods using diffusion tensor imaging (DTI) and DTI‐based deterministic and probabilistic tractography to access local and global diffusion changes in blast‐induced mild traumatic brain injury (bmTBI). Two hundred and two (202) male active US service members who reported persistent post‐concussion symptoms for more than 6 months after injury were recruited. An additional forty (40) male military controls were included for comparison. DTI results were examined in relation to post‐concussion and post‐traumatic stress disorder (PTSD) symptoms. No significant group difference in DTI metrics was found using voxel‐wise analysis. However, group comparison using tract profile analysis and tract specific analysis, as well as single subject analysis using tract profile analysis revealed the most prominent white matter microstructural injury in chronic bmTBI patients over the frontal fiber tracts, that is, the front‐limbic projection fibers (cingulum bundle, uncinate fasciculus), the fronto‐parieto‐temporal association fibers (superior longitudinal fasciculus), and the fronto‐striatal pathways (anterior thalamic radiation). Effects were noted to be sensitive to the number of previous blast exposures, with a negative association between fractional anisotropy (FA) and time since most severe blast exposure in a subset of the multiple blast‐exposed group. However, these patterns were not observed in the subgroups classified using macrostructural changes (T2 white matter hyperintensities). Moreover, post‐concussion symptoms and PTSD symptoms, as well as neuropsychological function were associated with low FA in the major nodes of compromised neurocircuitry. Hum Brain Mapp 38:352–369, 2017. © 2016 Wiley Periodicals, Inc.
The Temporal Instability of Resting State Network Connectivity in Intractable Epilepsy
Authors: Robinson Lucy F. , He Xiaosong , Barnett Paul , Doucet Gaёlle E. , Sperling Michael R. , Sharan Ashwini , Tracy Joseph I. 
Published: September 2016

AbstractObjectiveFocal epilepsies, such as temporal lobe epilepsy (TLE), are known to disrupt network activity in areas outside the epileptogenic zone [Tracy et al., 2015]. We devised a measure of temporal instability of resting state functional connectivity (FC), capturing temporal variations of BOLD correlations between brain regions that is less confounded than the “sliding window” approach common in the literature.MethodsWe investigated healthy controls and unilateral TLE patients (right and left seizure focus groups), utilizing group ICA to identify the default mode network (DMN), a network associated with episodic memory, a key cognitive deficit in TLE. Our instability analyses focused on: (1) connectivity between DMN region pairs, both within and between TLE patients and matched controls, (2) whole brain group differences between region pairs ipsilateral or contralateral to the epileptogenic temporal lobe.ResultsFor both the whole brain and a more focused analysis of DMN region pairs, temporal stability appears to characterize the healthy brain. The TLE patients displayed more FC instability compared to controls, with this instability more pronounced for the right TLE patients.SignificanceOur findings challenge the view that the resting state signal is stable over time, providing a measure of signal coherence change that may generate insights into the temporal components of network organization. The precuneus was the region within the DMN consistently expressing this instability, suggesting this region plays a key role in large scale temporal dynamics of the DMN, with such dynamics disrupted in TLE, putting key cognitive functions at risk.Hum Brain Mapp 38:528–540, 2017. ©2016 Wiley Periodicals, Inc.
Drying based on temperature‐detection‐assisted control in microwave‐assisted pulse‐spouted vacuum drying
Authors: Cao Xiaohuang , Zhang Min , Qian He , Mujumdar Arun S 
Published: September 2016

AbstractBACKGROUNDAn online temperature‐detection‐assisted control system of microwave‐assisted pulse‐spouted vacuum drying was newly developed. By using this system, temperature control can be automatically and continuously adjusted based on the detection of drying temperature and preset temperature. Various strategies for constant temperature control, linear temperature control and three‐step temperature control were applied to drying carrot cubes. Drying kinetics and the quality of various temperature‐controlled strategies online are evaluated for the new drying technology as well as its suitability as an alternative drying method.RESULTSDrying time in 70 °C mode 1 had the shortest drying time and lowest energy consumption in all modes. A suitable colour, highest re‐hydration ratio and fracture‐hardness, and longest drying time occurred in 30‐40‐50 °C mode 3. The number of hot spots was reduced in 40‐50‐60 °C mode 3. Acceptable carrot snacks were obtained in 50‐60‐70 °C mode 3 and 70 °C mode 2. All temperature curves showed that the actual temperatures followed the preset temperatures appropriately.CONCLUSIONSWith this system, a linear temperature‐controlled strategy and a three‐step temperature‐controlled strategy can improve product quality and heating non‐uniformity compared to constant temperature control, but need greater energy consumption and longer drying time. A temperature‐detection‐assisted control system was developed for providing various drying strategies as a suitable alternative in making a snack product. © 2016 Society of Chemical Industry
Economies of small: How a single‐journal publisher remains independent and grows
Authors: Holmes Edith 
Published: September 2016

Key points

Delivering focused and relevant content that researchers find valuable creates and sustains a dedicated and loyal audience.
Partnerships expand the Journal of Orthopaedic & Sports Physical Therapy (JOSPT)’s audience and reach and enable growth.
Introducing innovations at the right time is key – neither too soon nor too late.
Investing in specific initiatives developed through strategic planning moves JOSPT forward.
Elucidating the Molecular Processes for Creating Large or Bimodal Soft Nanoparticles from Block Copolymers via Blending
Authors: Ye Xianggui , Khomami Bamin 
Published: September 2016

By simply blending two diblock copolymers with the same chemistry but with different compositions one is able to create well‐defined larger soft ­nanoparticles as well as bimodal soft nanoparticles. Specifically, blending two diblock copolymers in a solvent good for both blocks followed by a gradual introduction of a non‐solvent results in a mixed micelle, larger than their pure block‐copolymer‐forming micelles. The formation of well‐defined larger micelle is due to the balance between the ability of the mixed micelles to assemble or merge in comparison to their pure diblock copolymer micelles. Evidently, the blending ratio, the mixing protocol, and non‐solvent addition rate are crucial to achieving well‐defined larger or bimodal micelles.
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Genistein and delphinidin antagonize the genotoxic effects of the mycotoxin alternariol in human colon carcinoma cells
Authors: Aichinger Georg , Beisl Julia , Marko Doris 
Published: September 2016

ScopeAlthough associated with anti‐oxidative properties, genistein has been reported to induce DNA strand breaks, whereby oxidative stress and topoisomerase poisoning are considered as potential mechanisms. In contrast, delphinidin, a catalytic topoisomerase inhibitor, is known to suppress the DNA‐damaging properties of several topoisomerase poisons. Recently, alternariol, a mycotoxin produced by Alternaria spp., was found not only to induce oxidative stress but also to act as a topoisomerase poison. As both, polyphenols and mycotoxins, might occur in our nutrition simultaneously, the question was addressed whether potential combinatory effects on DNA integrity have to be considered.Methods and resultsWe determined combinatory effects of either genistein or delphinidin with alternariol in HT‐29 cells. Cytotoxicity was assessed by WST‐1 and SRB assays, whereby only weak interactions were observed. The comet assay revealed significant antagonistic interactions of both polyphenols with the genotoxicity of AOH. The underlying mechanism comprises the suppression of alternariol‐mediated stabilization of DNA/topoisomerase‐II‐intermediates, as observed in the ICE assay. Furthermore, DEL but not GEN was found to suppress AOH‐mediated oxidative stress.ConclusionOur data indicate that a respective polyphenol‐rich diet might aid to protect against genotoxic damages caused by AOH, whereby bioactive concentrations of DEL are predominantly expected locally in the intestines.
Prediction of 195Pt NMR of photoactivable diazido‐ and azine‐Pt(IV) anticancer agents by DFT computational protocols
Authors: Tsipis Athanassios C. , Karapetsas Ioannis N. 
Published: September 2016

Abstract195Pt NMR chemical shifts for a series of large‐sized photoactivable anticancer diazido‐Pt(IV), homopiperizine‐Pt(IV) and multifunctional azine‐Pt(IV) complexes hardly to be probed experimentally and by sophisticated four‐component and two‐component relativistic calculations are predicted with high accuracy by density functional theory computational protocols. The calculated 195Pt NMR chemical shifts constitute a crucial descriptor for making highly predictive one‐parameter quantitative structure activity relationships models that help in designing photoactivable Pt(IV)‐based antitumor agents with high cytotoxicity and selectivity. Copyright © 2016 John Wiley & Sons, Ltd.
Layer‐by‐layer assembly of readily detachable chitosan and poly(acrylic acid) polyelectrolyte multilayer films
Authors: Gates Samantha J. , Shukla Anita 
Published: September 2016

ABSTRACTFree‐standing layer‐by‐layer (LbL) assembled thin films have recently found utility in a broad range of applications. Previously reported free‐standing LbL films have generally required covalent modifications to improve aqueous stability and render these films suitable for biomedical applications. Here, we engineered chitosan and poly(acrylic acid) containing polyelectrolyte multilayer films, which are readily detached from hydrophilic silicon in aqueous conditions. These films demonstrate remarkable stability over 28 days in simulated in vivo conditions (pH 7.4, phosphate buffered saline at 37 °C) without the incorporation of any covalent crosslinking modifications. These films exhibit moduli (27–420 kPa) resembling that of many biological tissues including tendon, show high visible light transmittance of greater than 50%, and prevent fibronectin adsorption. The properties of this new detachable LbL film architecture indicate its promise for use in a variety of applications, particularly in medicine and biotechnology. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 127–131
Effect of temperature–bias annealing on the hysteresis and subthreshold behavior of multilayer MoS2 transistors
Authors: Giannazzo F. , Fisichella G. , Piazza A. , Di Franco S. , Greco G. , Agnello S. , Roccaforte F. 
Published: September 2016

The transfer characteristics (ID–VG) of multilayers MoS2 transistors with a SiO2/Si backgate and Ni source/drain contacts have been measured on as‐prepared devices and after annealing at different temperatures (Tann from 150 °C to 200 °C) under a positive bias ramp (VG from 0 V to +20 V). Larger Tann resulted in a reduced hysteresis of the ID–VG curves (from ∼11 V in the as‐prepared sample to ∼2.5 V after Tann at 200 °C). The field effect mobility (∼30 cm2 V–1 s–1) remained almost unchanged after the annealing. On the contrary, the subthreshold characteristics changed from the common n‐type behaviour in the as‐prepared device to the appearance of a low current hole inversion branch after annealing. This latter effect indicates a modification of the Ni/MoS2 contact that can be explained by the formation of a low density of regions with reduced Schottky barrier height (SBH) for holes embedded in a background with low SBH for electrons. Furthermore, a temperature dependent analysis of the subthreshold characteristics revealed a reduction of the interface traps density from ∼9 × 1011 eV–1cm–2in the as‐prepared device to ∼2 × 1011 eV–1cm–2after the 200 °C temperature–bias annealing, which is consistent with the observed hysteresis reduction.
Schematic representation of a back‐gated multilayer MoS2 field effect transistor (left) and transfer characteristics (right) measured at 25 °C on an as‐prepared device and after the temperature–bias annealing at 200 °C under a positive gate bias ramp from 0 V to +20 V.magnified imageSchematic representation of a back‐gated multilayer MoS2 field effect transistor (left) and transfer characteristics (right) measured at 25 °C on an as‐prepared device and after the temperature–bias annealing at 200 °C under a positive gate bias ramp from 0 V to +20 V.
A decoupling control strategy for wind turbine blades equipped with active flow controllers
Authors: Macquart Terence , Maheri Alireza , Busawon Krishna 
Published: September 2016

AbstractThe use of active controls has shown to be of substantial help in supporting the increasing size of wind turbines by reducing peak stresses and fatigue loads. In this respect, this paper proposes the use of intuitive frequency‐based control strategies for reducing loads in wind turbine blades equipped with multi‐input multi‐output (MIMO) active flow controllers. For that purpose, a loop‐shaping approach is considered for analysing the dynamic of actively controlled wind turbine blades. Preliminary aeroelastic simulations are carried out to validate the results. It is shown that the MIMO vibration control problem can effectively be decomposed into a number of decoupled single‐input single‐output control problems because of the strong correlation between the dominant aeroelastic blade dynamics and actuator deployments. As a result, it is demonstrated that classical single‐input single‐output control systems can perform as efficiently as MIMO controllers for damping the aeroelastic dynamics of wind turbine blades. Copyright © 2016 John Wiley & Sons, Ltd.
Total Extraperitoneal Hernia Repair: Residency Teaching Program and Outcome Evaluation
Authors: Garofalo Fabio , Mota‐Moya Pau , Munday Andrew , Romy Sébastien 
Published: September 2016

AbstractBackgroundTotal extraperitoneal (TEP) hernia repair has been shown to offer less pain, shorter postoperative hospital stay and earlier return to work when compared to open surgery. Our institution routinely performs TEP procedures for patients with primary or recurrent inguinal hernias. The aim of this study was to show that supervised senior residents can safely perform TEP repairs in a teaching setting.MethodsAll consecutive patients treated for inguinal hernias by laparoscopic approach from October 2008 to June 2012 were retrospectively analyzed from a prospective database.ResultsA total of 219 TEP repairs were performed on 171 patients: 123 unilateral and 48 bilateral. The mean patient age was 51.6 years with a standard deviation (SD) of ± 15.9. Supervised senior residents performed 171 (78 %) and staff surgeons 48 (22 %) TEP repairs, respectively. Thirty‐day morbidity included cases of inguinal paresthesias (0.4 %, n = 1), umbilical hematomas (0.9 %, n = 2), superficial wound infections (0.9 %, n = 2), scrotal hematomas (2.7 %, n = 6), postoperative urinary retentions (2.7 %, n = 6), chronic pain syndromes (5 %, n = 11) and postoperative seromas (6.7 %, n = 14). Overall, complication rates were 18.7 % for staff surgeons and 19.3 % for residents (p = 0.83). For staff surgeons and residents, mean operative times for unilateral hernia repairs were 65 min (SD ± 18.9) and 77.6 min (SD ± 29.8) (p = 0.043), respectively, while mean operative times for bilateral repairs were 115 min (SD ± 40.1) and 103.6 (SD ± 25.9) (p = 0.05).ConclusionsTEP repair is a safe procedure when performed by supervised senior surgical trainees. Teaching of TEP should be routinely included in general surgery residency programs.
Comparing methods of acquiring mammalian endozoochorous seed dispersal distance distributions
Authors: Mise Yumiko , Yamazaki Koji , Soga Masashi , Koike Shinsuke 
Published: September 2016

AbstractResearch on endozoochorous seed dispersal is needed to further understand plant ecology and evolution. There are several methods for calculating the distribution of seed dispersal distances, although many studies use the “combination of gut retention time and movement data” (CGM) method to determine the potential seed dispersal distance distribution (PSD). However, there have been no evaluations of between PSD values acquired by CGM and seed dispersal distance distributions calculated using other methods. The main purpose of this study was to compare methods of determining seed dispersal distance distributions using raccoon dogs (Nyctereutes procyonoides). We calculated estimated seed dispersal distance distribution (ESD) using the bait‐marker method and PSD using the CGM method. There were no differences between the ESD and PSD results with regard to basic dispersal distance distributions. The results indicate that if the region from which animal movement data was acquired and the region from which markers for the bait‐marker method have been collected are the same, the distance distributions using the two methods may match. Additionally, though there were differences in seed mimic gut retention times (GRTs) between the two baits used (median GRT, fruits: 8 h 50 min, animal materials: 12 h 55 min), there were no differences in PSD between the two baits. This indicates that disperser movement has a stronger effect on dispersal distance distribution than GRT when using the CGM method.
Fünf Jahre PID-Gesetz
Authors: Wostry Thomas 
Published: September 2016

Zusammenfassung
Dieser Beitrag stellt vor dem Hintergrund der fast fünf Jahre bestehenden gesetzlichen Regelungen zur PID die Entwicklung einschlägiger Vorschriften zu ihrer Umsetzung dar und erörtert in diesem Zusammenhang einige aktuelle Fragestellungen. Thematisiert werden insbesondere die Entwicklung der PID-Verordnung und die Regelungen über die Zulassung von PID-Zentren. Der Beitrag gelangt zu dem Ergebnis, dass die Umsetzung der bundesrechtlichen Regelungen im Ergebnis durch die Schaffung von Übergangszeiträumen nicht als durchweg geglückt anzusehen ist und die entsprechenden Vorschriften inhaltlich nur bedingt überzeugen können.
Experiencing authenticity – the core of student learning in clinical practice
Authors: Manninen Katri 
Published: September 2016

Introduction Learning in clinical practice is challenging regarding organizational and pedagogical issues. Clinical education wards are one way to meet these challenges by focusing on both patient care and student learning. However, more knowledge is needed about how students’ learning can be enhanced and about patients’ and supervisors’ roles in these settings.
Methods The aim was to explore nursing students’ learning on a clinical education ward with an explicit pedagogical framework. Semi-structured interviews of students were analyzed using qualitative content analysis and an ethnographic study including observations and follow-up interviews of students, patients and supervisors was conducted.
Results The core of student meaningful learning experiences both external and internal authenticity. Students in early stages immediately created mutual relationships, experienced both external and internal authenticity, and patients became active participants in student learning. Without a mutual relationship, patients passively let students practice on their bodies. Students nearing graduation experienced only external authenticity, creating uncertainty as a threshold for learning. Caring for patients with complex needs helped students overcome the threshold and experience internal authenticity. Supervisors’ challenges were to balance patient care and student learning by working as a team. They supported students coping with the complex challenges on the ward.
Discussion/Conclusion Students need to experience external and internal authenticity to make learning meaningful. Experiencing authenticity, involving meaning-making processes and knowledge construction, is linked to transformative learning and overcoming thresholds.
Demonstration of Lesions Produced by Cooled Radiofrequency Neurotomy for Chronic Osteoarthritic Knee Pain: A Case Presentation
Authors: Farrell Michael E. , Gutierrez Genaro , Desai Mehul J. 
Published: September 2016

AbstractThis case presentation demonstrates radiographic evidence of lesions created following cooled radiofrequency (cRF) neurotomy of the knee. A 67‐year‐old man presented with chronic left knee osteoarthritis, pain, and disability. After a failed trial of conservative treatments, the patient underwent diagnostic genicular nerve blocks and subsequent cRF neurotomy of the left knee. Shortly after cRF, magnetic resonance imaging (MRI) of the left knee was performed. On MRI, lesions created by cRF ablation were identified. The images presented in this case offer a visual explanation for the success of cRF in the treatment of knee osteoarthritis.Level of EvidenceV
MBOAT7 rs641738 increases risk of liver inflammation and transition to fibrosis in chronic hepatitis C
Authors: Thabet Khaled , Asimakopoulos Anastasia , Shojaei Maryam , Romero-Gomez Manuel , Mangia Alessandra , Irving William L. , Berg Thomas , Dore Gregory J. , Grønbæk Henning , Sheridan David , Abate Maria Lorena , Bugianesi Elisabetta , Weltman Martin , Mollison Lindsay , Cheng Wendy , Riordan Stephen , Fischer Janett , Spengler Ulrich , Nattermann Jacob , Wahid Ahmed , Rojas Angela , White Rose , Douglas Mark W. , McLeod Duncan , Powell Elizabeth , Liddle Christopher , van der Poorten David , George Jacob , Eslam Mohammed ,   International Liver Disease Genetics Consortium, Gallego-Duran Rocio , Applegate Tanya , Bassendine Margaret , Rosso Chiara , Mezzabotta Lavinia , Leung Reynold , Malik Barbara , Matthews Gail , Grebely Jason , Fragomeli Vincenzo , Jonsson Julie R. , Santaro Rosanna 
Published: September 2016

AbstractCirrhosis likely shares common pathophysiological pathways despite arising from a variety of liver diseases. A recent GWAS identified rs641738, a polymorphism in the MBOAT7 locus, as being associated with the development of alcoholic cirrhosis. Here we explore the role of this variant on liver inflammation and fibrosis in two cohorts of patients with chronic hepatitis C. In 2,051 patients, rs641738 associated with severe hepatic inflammation and increased risk of fibrosis, as well as fast fibrosis progression. At functional level, rs641738 associated with MBOAT7 transcript and protein levels in liver and blood, and with serum inflammatory, oxidative stress and macrophage activation markers. MBOAT7 was expressed in immune cell subsets, implying a role in hepatic inflammation. We conclude that the MBOAT7 rs641738 polymorphism is a novel risk variant for liver inflammation in hepatitis C, and thereby for liver fibrosis.