bluuebunny/crossref_metadata_2025_split huggingface dataset:
Completion of the mixed unit interval graphs hierarchy
Authors: Talon Alexandre , Kratochvíl Jan 
Published: June 2017

AbstractWe describe the missing class of the hierarchy of mixed unit interval graphs. This class is generated by the intersection graphs of families of unit intervals that are allowed to be closed, open, and left‐closed‐right‐open. (By symmetry, considering closed, open, and right‐closed‐left‐open unit intervals generates the same class.) We show that this class lies strictly between unit interval graphs and mixed unit interval graphs. We give a complete characterization of this new class, as well as quadratic‐time algorithms that recognize graphs from this class and produce a corresponding interval representation if one exists. We also show that the algorithm from Shuchat et al. [8] directly extends to provide a quadratic‐time algorithm to recognize the class of mixed unit interval graphs.
Attachment theory at work: A review and directions for future research
Authors: Yip Jeffrey , Ehrhardt Kyle , Black Hunter , Walker Dayna O. 
Published: June 2017

SummaryThe influence of attachment theory on organizational scholarship is growing, with more articles published on the subject in the past 5 years than the preceding 25 years combined. Prior research and reviews have primarily focused on attachment styles and their relationship with organizational outcomes. However, in the past 5 years, organizational scholars have begun exploring new directions in attachment research such as situational influences on attachment states, attachment as a moderating variable, and attachment as a dynamic process in various forms of work relationships. These advances offer new directions for organizational behavior research, notably through the lens of the attachment behavioral system—an innate psychological system that accounts for why and how people seek support from others. In this paper, we provide an overarching framework for understanding attachment dynamics in organizations and review key findings from attachment theory research on dyadic relationships, group dynamics, and the employee–organization relationship. We further discuss promising areas for future organizational research on attachment, as well as methodological developments in the priming of attachment states.
Optimization of puncture injury to rat caudal disc for mimicking early degeneration of intervertebral disc
Authors: Hu Ming‐Hsiao , Yang Kai‐Chiang , Chen Yeong‐Jang , Sun Yuan‐Hui , Lin Feng‐Huei , Yang Shu‐Hua 
Published: June 2017

ABSTRACTThe caudal discs of rats have been proposed as a puncture model in which intervertebral disc (IVD) degeneration can be induced and novel therapies can be tested. For biological repair, treatments for ongoing IVD degeneration are ideally administered during the earlier stages. The purpose of this study was to elucidate the optimal puncture needle size for creating a model that mimicked the earlier stages of IVD degeneration. According to the disc height index, histologic score, and MRI grading, a puncture needle sized 21G or larger induced rapid degenerative processes in rat caudal discs during the initial 2–4 weeks. The degenerative changes were severe and continued deteriorating after 4 weeks. Conversely, puncture injury induced by needles sized 25G or smaller also produced degenerative changes in rat caudal discs during initial 2–4 weeks; however, the changes were less severe. Furthermore, the degenerative process became stabilized and showed no further deterioration or spontaneous recovery after 4 weeks. In the discs punctured by 25G needles, the expression of collagen I was increased at 2–4 weeks with a gradually fibrotic transformation thereafter. The expressions of collagen II and SOX9 were enhanced initially but returned to pre‐injury levels at 4–8 weeks. The above‐mentioned findings were more compatible with earlier degeneration in discs punctured by needles sized 25G or smaller than by needles sized 21G or larger, and the appropriate timing for intradiscal administration of proposed therapeutic agents would be 4 weeks or longer after puncture. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:202–211, 2018.
Maintaining good miRNAs in the body keeps the doctor away?: Perspectives on the relationship between food‐derived natural products and microRNAs in relation to exosomes/extracellular vesicles
Authors: Otsuka Kurataka , Yamamoto Yusuke , Matsuoka Ryosuke , Ochiya Takahiro 
Published: June 2017

AbstractDuring the last decade, it has been uncovered that microRNAs (miRNAs), a class of small non‐coding RNAs, are related to many diseases including cancers. With an increase in reports describing the dysregulation of miRNAs in various tumor types, it has become abundantly clear that miRNAs play significant roles in the formation and progression of cancers. Intriguingly, miRNAs are present in body fluids because they are packed in exosomes/extracellular vesicles and released from all types of cells. The miRNAs in the fluids are measured in a relatively simple way and the profile of miRNAs is likely to be an indicator of health condition. In recent years, various studies have demonstrated that some naturally occurring compounds can control tumor‐suppressive and oncogenic miRNAs in a positive manner, suggesting that food‐derived compounds could maintain the expression levels of miRNAs and help maintain good health. Therefore, our daily food and compounds in food are of great interest. In addition, exogenous diet‐derived miRNAs have been indicated to function in the regulation of target mammalian transcripts in the body. These findings highlight the possibility of diet for good health through the regulation of miRNAs, and we also discuss the perspective of food application and health promotion.
Predictive therapeutic planning for irreversible electroporation treatment of spontaneous malignant glioma
Authors: Garcia Paulo A. , Kos Bor , Rossmeisl John H. , Pavliha Denis , Miklavčič Damijan , Davalos Rafael V. 
Published: June 2017

PurposeIrreversible electroporation (IRE) has been developed as a promising minimally invasive treatment to ablate spontaneous brain tumors with pulsed electric fields in canine patients. The purpose of the study is to determine the Peleg‐Fermi parameters needed to incorporate pulse number and pulse duration into the therapeutic planning of IRE.MethodsSeven canine patients were treated with IRE for spontaneous malignant glioma with MRI‐based treatment planning. The treatment planning method consists of building patient‐specific finite element models and using them to compute electric fields used in the IRE treatment. We evaluate the predictive power of tumor coverage with electric field alone vs. cell kill probability using radiographically confirmed clinical outcomes.ResultsResults of post‐treatment diagnostic imaging, tumor biopsies, and neurological examinations indicated successful tumor ablation without significant direct neurotoxicity in six of the seven dogs. Objective tumor responses were seen in four (80%) of five dogs with quantifiable target lesions according to RANO criteria. Two dogs experienced survivals in excess of 1 yr, including one dog that resulted in complete response to IRE treatment for 5+ years to date. Tumor fraction exposed to electric field over 600 V/cm was between 0.08 and 0.73, while tumor fraction exposed to electric field over 300 V/cm was between 0.17 and 0.95. Probability of cell kill of ≥ 90% was found in tumor volume fractions between 0.21 and 0.99.ConclusionsWe conclude that IRE is a safe and effective minimally invasive treatment for malignant glioma and can be predicted with the Peleg‐Fermi cell kill probability function. A tumor coverage of ≥ 0.9 at a cell kill probability ≥ 90% can be used to guide IRE treatments of spontaneous malignant glioma based on the radiographically confirmed clinical outcomes achieved.
Assembly and performance of a 6.4 T cryogen‐free dynamic nuclear polarization system
Authors: Kiswandhi Andhika , Niedbalski Peter , Parish Christopher , Wang Qing , Lumata Lloyd 
Published: June 2017

We report on the assembly and performance evaluation of a 180‐GHz/6.4 T dynamic nuclear polarization (DNP) system based on a cryogen‐free superconducting magnet. The DNP system utilizes a variable‐field superconducting magnet that can be ramped up to 9 T and equipped with cryocoolers that can cool the sample space with the DNP assembly down to 1.8 K via the Joule–Thomson effect. A homebuilt DNP probe insert with top‐tuned nuclear magnetic resonance coil and microwave port was incorporated into the sample space in which the effective sample temperature is approximately 1.9 K when a 180‐GHz microwave source is on during DNP operation. 13C DNP of [1‐13C] acetate samples doped with trityl OX063 and 4‐oxo‐TEMPO in this system have resulted in solid‐state 13C polarization levels of 58 ± 3% and 18 ± 2%, respectively. The relatively high 13C polarization levels achieved in this work have demonstrated that the use of a cryogen‐free superconducting magnet for 13C DNP is feasible and in fact, relatively efficient—a major leap to offset the high cost of liquid helium consumption in DNP experiments.
Respiratory motion model based on the noise covariance matrix of a receive array
Authors: Andreychenko A. , Denis de Senneville B. , Navest R.J.M. , Tijssen R.H.N. , Lagendijk J.J.W. , van den Berg C.A.T. 
Published: June 2017

PurposeTracking of the internal anatomy by means of a motion model that uses the MR‐derived motion fields and noise covariance matrix (NCM) dynamic as a surrogate signal.MethodsA 2D respiratory motion model was developed based on the MR‐derived motion fields and the NCM of a receive array used in MRI. Temporal dynamics of the NCM were used as a motion surrogate for a linear correspondence motion model. The model performance was tested on five healthy volunteers with a liver as the target. The motion fields were calculated from the cineMR frames with an optical flow registration tool.ResultsThe model estimated the liver motion with an average residual error of 2.3 mm (13% of the motion amplitude). The model formation takes 3 min and the model latency was 0.5 s in the current implementation. The limiting factor for the latency is the current update time of the NCM (0.48 s), which in principle can be reduced to 0.004 s with an alternative way to determine the NCM.ConclusionsThe 2D respiratory motion of the liver can be effectively estimated with the linear motion model that uses the temporal behavior of the NCM as motion surrogate. Magn Reson Med 79:1730–1735, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Increased Adipocyte Size, Macrophage Infiltration, and Adverse Local Adipokine Profile in Perirenal Fat in Cushing's Syndrome
Authors: Roerink Sean H.P.P. , Wagenmakers Margreet A.E.M. , Langenhuijsen Johan F. , Ballak Dov B. , Rooijackers Hanne M.M. , d'Ancona Frank C. , van Dielen François M. , Smit Jan W.A. , Plantinga Theo S. , Netea‐Maier Romana T. , Hermus Ad R.M.M. 
Published: June 2017

ObjectiveTo analyze changes in fat cell size, macrophage infiltration, and local adipose tissue adipokine profiles in different fat depots in patients with active Cushing's syndrome.MethodsSubcutaneous (SC) and perirenal (PR) adipose tissue of 10 patients with Cushing's syndrome was compared to adipose tissue of 10 gender‐, age‐, and BMI‐matched controls with regard to adipocyte size determined by digital image analysis on hematoxylin and eosin stainings, macrophage infiltration determined by digital image analysis on CD68 stainings, and adipose tissue leptin and adiponectin levels using fluorescent bead immunoassays and ELISA techniques.ResultsCompared to the controls, mean adipocyte size was larger in PR adipose tissue in patients. The percentage of macrophage infiltration of the PR adipose tissue and PR adipose tissue lysate leptin levels were higher and adiponectin levels were lower in SC and PR adipose tissue lysates in patients. The adiponectin levels were also lower in the SC adipose tissue supernatants of patients. Associations were found between the severity of hypercortisolism and PR adipocyte size.ConclusionsCushing's syndrome is associated with hypertrophy of PR adipocytes and a higher percentage of macrophage infiltration in PR adipose tissue. These changes are associated with an adverse local adipokine profile.
From charge‐transfer excitations to charge‐transport phenomena in organic molecular crystals
Authors: Zoppi Laura , Baldridge Kim K. 
Published: June 2017

AbstractFunctional devices based on properties inherent in single organic molecules offer promise for use in technological applications, particularly building blocks that can take on diverse electronic functions with tuning through chemical design and synthesis. Morphological features of curved aromatic structures offer exploration into a wealth of phenomenology as a function of environment, such as exemplified for super atomic molecular orbitals. This review discusses current state‐of‐the‐art electronic structure approaches for prediction of structural, electronic, optical, and transport properties of planar and curved designed components. Important principle for design lies in understanding and control of the solid‐state packing and intermolecular interactions of individual building block units, for which many body perturbation techniques are essential. Molecular and solid state engineering is shown to be effective toward tailoring new materials with optimal transport properties, with valuable insight provided by high level computational prediction.
Quantification of power losses due to wind turbine wake interactions through SCADA, meteorological and wind LiDAR data
Authors: El‐Asha Said , Zhan Lu , Iungo Giacomo Valerio 
Published: June 2017

AbstractPower production of an onshore wind farm is investigated through supervisory control and data acquisition data, while the wind field is monitored through scanning light detection and ranging measurements and meteorological data acquired from a met‐tower located in proximity to the turbine array. The power production of each turbine is analysed as functions of the operating region of the power curve, wind direction and atmospheric stability. Five different methods are used to estimate the potential wind power as a function of time, enabling an estimation of power losses connected with wake interactions. The most robust method from a statistical standpoint is that based on the evaluation of a reference wind velocity at hub height and experimental mean power curves calculated for each turbine and different atmospheric stability regimes. The synergistic analysis of these various datasets shows that power losses are significant for wind velocities higher than cut‐in wind speed and lower than rated wind speed of the turbines. Furthermore, power losses are larger under stable atmospheric conditions than for convective regimes, which is a consequence of the stability‐driven variability in wake evolution. Light detection and ranging measurements confirm that wind turbine wakes recover faster under convective regimes, thus alleviating detrimental effects due to wake interactions. For the wind farm under examination, power loss due to wake shadowing effects is estimated to be about 4% and 2% of the total power production when operating under stable and convective conditions, respectively. However, cases with power losses about 60‐80% of the potential power are systematically observed for specific wind turbines and wind directions. Copyright © 2017 John Wiley & Sons, Ltd.
Dynamic fracture behavior of a nanocrack in a piezoelectric plane
Authors: Rangelov Tsviatko , Dineva Petia 
Published: June 2017

AbstractScattering of time harmonic plane waves by a finite blunt nano‐crack in a homogeneous transversely isotropic piezoelectric plane under plane strain conditions is studied. The mechanical model combines: (a) classical elastodynamic theory for the bulk piezoelectric solid, where the total wave comprises both incident and scattered wave field; (b) non‐classical boundary conditions and localized constitutive equation for the interface between the crack and piezoelectric matrix within the frame of the Gurtin‐Murdoch surface elasticity theory. The computational approach uses a non‐hypersingular traction based boundary integral equation method (BIEM) basing on the fundamental solution derived in closed form by Radon transforms. Furthermore, the parametric study is presented which demonstrates the sensitivity of the generalized stress concentration fields near the crack‐tip to the key parameters as the size of the crack, surface properties, coupled nature of the piezoelectricity phenomenon, type and properties of the incident wave such as frequency, wave length and wave propagation direction, dynamic interaction between the crack, incident wave and coupled electro‐elastic continuum.
Dilute acid pretreatment of sorghum biomass to maximize the hemicellulose hydrolysis with minimized levels of fermentative inhibitors for bioethanol production
Authors: Deshavath Narendra Naik , Mohan Mood , Veeranki Venkata Dasu , Goud Vaibhav V. , Pinnamaneni Srinivasa Rao , Benarjee Tamal 
Published: June 2017

Abstract
Conversion of lignocellulosic biomass into monomeric carbohydrates is economically beneficial and suitable for sustainable production of biofuels. Hydrolysis of lignocellulosic biomass using high acid concentration results in decomposition of sugars into fermentative inhibitors. Thus, the main aim of this work was to investigate the optimum hydrolysis conditions for sorghum brown midrib IS11861 biomass to maximize the pentose sugars yield with minimized levels of fermentative inhibitors at low acid concentrations. Process parameters investigated include sulfuric acid concentration (0.2–1 M), reaction time (30–120 min) and temperature (80–121 °C). At the optimum condition (0.2 M sulfuric acid, 121 °C and 120 min), 97.6% of hemicellulose was converted into xylobiose (18.02 mg/g), xylose (225.2 mg/g), arabinose (20.2 mg/g) with low concentration of furfural (4.6 mg/g). Furthermore, the process parameters were statistically optimized using response surface methodology based on central composite design. Due to the presence of low concentration of fermentative inhibitors, 78.6 and 82.8% of theoretical ethanol yield were attained during the fermentation of non-detoxified and detoxified hydrolyzates, respectively, using Pichia stipitis 3498 wild strain, in a techno-economical way.
Optimization of cultivation conditions for biotechnological production of lipid by Rhodotorula kratochvilovae (syn, Rhodosporidium kratochvilovae) SY89 for biodiesel preparation
Authors: Jiru Tamene Milkessa , Groenewald Marizeth , Pohl Carolina , Steyn Laurinda , Kiggundu Nicholas , Abate Dawit 
Published: June 2017

Abstract

Rhodotorula kratochvilovae (syn, Rhodosporidium kratochvilovae) SY89, an oleaginous yeast, isolated from Ethiopian soil, was grown under nitrogen-limited media. The capacity this with respect to biomass production, lipid yield and lipid content was evaluated. The influence of inoculum size, carbon sources, variations in glucose concentration, nitrogen sources, C/N ratio, pH, temperature, agitation, and aeration rate and incubation period were investigated. Inoculum size of 10% v/v, glucose as a carbon source at 50 g/L glucose, 0.50 g/L yeast extract and 0.31 g/L (NH4)2SO4, C/N ratio of 120, pH 5.5, incubation temperature of 30 °C, 225 rpm, 0.2 as aeration ratio and 144 h of incubation were found to be optimum conditions for lipid production. Then the yeast was grown in a batch bioreactor by combining the different optimized parameters together. Under the optimized conditions, the yeast gave maximum biomass (15.34 ± 1.47 g/L), lipid yield (8.60 ± 0.81 g/L) and lipid content (56.06 ± 1.70%). The dominant fatty acids exhibited in order of their relative abundance (%w/w), were oleic, palmitic, linoleic, stearic, linolenic and palmitoleic acids. The concentration of saturated and monounsaturated fatty acids adds up 78.63 ± 2.19%. This suggests that this strain could be used as a good feedstock for biodiesel production.
Proteomic characterization and bio-informatic analysis of differentially expressed E. coli Nissle 1917 proteins with response to cocoti wine stress
Authors: Kathera Chandrasekhar , Dulla Esther Lebonah , Chinahadri Venkata Prasad , Ramesh Thanu Sree Mallakuntla , Basavaraju Sreedevi , Jasti Pramodakumari 
Published: June 2017

Abstract
The present study emphases the comparative proteomic analysis of Escherichia coli Nissle 1917 under cocoti palm wine stress and identified differentially expressed proteins. Protein samples were analyzed by 2-D, MALDI-TOF combined with MS access. In 2-D electrophoresis, eight differentially expressed proteins were identified: five up-regulated, two down-regulated and one newly expressed protein. Protein spots were digested with trypsin for MALDI-TOF–MS analysis; protein sequences were obtained from MASCOT search. Sequences were aligned with template using Swiss Model server. Phyre-2 was used to predict homology modeling, RasMol was used to analyze the modeling structures, PSVS server was utilized to validate the protein structure by Ramachandran’s plot analysis, physical and chemical properties were analyzed using ProtParam server, Phylogenetic tree was constructed by Mega4. UniProt search helps to find protein functional information of differentially expressed proteins, involved in catalytic activities, regulation mechanisms, DNA damage stimulus, anti-termination and termination process, protein binding, electron transport mechanism, and cell signaling process functions. A detailed exploration of the proteins under cocoti palm wine stress have provided the composition, structure and functions of the expressed proteins for further investigation.
Joint inversion of induction and galvanic logging data in axisymmetric geological models
Authors: Mikhaylov I.V. , Glinskikh V.N. , Nikitenko M.N. , Surodina I.V. 
Published: June 2017

Abstract
We have developed a computational algorithm for joint inversion of array induction and galvanic data in 2D models. It is based on a finite-difference solver and nonlinear minimization and is designed to develop realistic geoelectric models of complex fluid-saturated formations. The algorithm is tested and verified on noisy synthetic induction and galvanic data. The obtained 2D inversion results are compared with those corresponding to the traditional 1D radial approach. The developed algorithm was used to conduct joint 2D inversion of VEMKZ and BKZ logs from the Fedorovskoe and Vostochno-Surgutskoe oil fields in the E–W striking Ob’ River area.
On the scaling of jetting from bubble collapse at a liquid surface
Authors: Krishnan Sangeeth , Hopfinger E. J. , Puthenveettil Baburaj A. 
Published: June 2017

We present scaling laws for the jet velocity resulting from bubble collapse at a liquid surface which bring out the effects of gravity and viscosity. The present experiments conducted in the range of Bond numbers $0.004<Bo<2.5$ and Ohnesorge numbers $0.001<Oh<0.1$ were motivated by the discrepancy between previous experimental results and numerical simulations. We show here that the actual dependence of $We$ on $Bo$ is determined by the gravity dependency of the bubble immersion (cavity) depth which has no power-law variation. The power-law variation of the jet Weber number, $We\sim 1/\sqrt{Bo}$, suggested by Ghabache et al. (Phys. Fluids, vol. 26 (12), 2014, 121701) is only a good approximation in a limited range of $Bo$ values ($0.1<Bo<1$). Viscosity enters the jet velocity scaling in two ways: (i) through damping of precursor capillary waves which merge at the bubble base and weaken the pressure impulse, and (ii) through direct viscous damping of the jet formation and dynamics. These damping processes are expressed by a dependence of the jet velocity on Ohnesorge number from which critical values of $Oh$ are obtained for capillary wave damping, the onset of jet weakening, the absence of jetting and the absence of jet breakup into droplets.