bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redox regulation in tumor cell epithelial–mesenchymal transition: molecular basis and therapeutic strategy
Authors: Jiang Jingwen , Wang Kui , Chen Yan , Chen Haining , Nice Edouard C , Huang Canhua 
Published: August 2017

AbstractEpithelial–mesenchymal transition (EMT) is recognized as a driving force of cancer cell metastasis and drug resistance, two leading causes of cancer recurrence and cancer-related death. It is, therefore, logical in cancer therapy to target the EMT switch to prevent such cancer metastasis and recurrence. Previous reports have indicated that growth factors (such as epidermal growth factor and fibroblast growth factor) and cytokines (such as the transforming growth factor beta (TGF-β) family) are major stimulators of EMT. However, the mechanisms underlying EMT initiation and progression remain unclear. Recently, emerging evidence has suggested that reactive oxygen species (ROS), important cellular secondary messengers involved in diverse biological events in cancer cells, play essential roles in the EMT process in cancer cells by regulating extracellular matrix (ECM) remodeling, cytoskeleton remodeling, cell–cell junctions, and cell mobility. Thus, targeting EMT by manipulating the intracellular redox status may hold promise for cancer therapy. Herein, we will address recent advances in redox biology involved in the EMT process in cancer cells, which will contribute to the development of novel therapeutic strategies by targeting redox-regulated EMT for cancer treatment.
How film genres are a product of biology, evolution and culture—an embodied approach
Authors: Grodal Torben 
Published: August 2017

AbstractThe article describes how basic cognitive and emotional systems of the embodied brain are products of a long evolutionary history and how this determines the way in which the major film genres are constructed. It synthesizes research from evolutionary psychology and cognitive film studies, as well as moral psychology. It explains how the film experience is embodied: experienced not only cognitively but with the whole body and its interaction with the world. Also discussed is how the biological underpinning of genres are based on three major types of emotions: a group of reptilian emotions central to action and adventure; a group ofmammalianemotions related to offspring of care; and separation panic/grief. A special human development to enhance group living has expanded emotions of care to also underpin emotions linked to group living such as loyalty to tribe, aggression towards out-groups and submission to tribal hierarchy, central in war, sci-fi and fantasy films, and also emotions related to social rituals such as comedy, tragedy and musical. A discussion is also offered of how the historical development from hunter-gatherers via societies based on agriculture to the present post-agrarian society has moulded moral emotions; this is exemplified in relation to crime films. Finally, also considered is how age and gender influence genre preferences.
Song translation and AVT
Authors: Jiménez Rocío García 
Published: August 2017

AbstractThere is no doubt that music plays an important role in people’s lives and, consequently, in different societies and cultures. Through music, the distinctive features of societies and cultures can be appreciated, while, at the same time, its condition of universal language acts as a means of communication among them. Translation Studies has recently started to pay attention to the relationship between translation and music. The study of the translation of songs, opera and other musical products is a subject that can enrich the field. In addition to this, owing to the peculiar nature of the musical text, the translation of music can be linked to other disciplines within Translation Studies, as is the case with AVT. In this work, we will analyse the similarities and differences between AVT and song translation. We will show that some of the translation strategies used in AVT can be applied to other types of multimodal translation, like song translation. We will also consider some cases in which song translation becomes part of AVT, as happens in the translation of TV series or films in which there are songs.
Translating the socialist nation
Authors: Ni Xiuhua 
Published: August 2017

Abstract
The first seventeen years of the People’s Republic of China (PRC, 1949–1966) was a critical period for the newly established nation to gain international recognition. The period witnessed a unique translation activity, i.e. SL-generated translation of a large number of classical and modern Chinese literature into English and other foreign languages. These state-sponsored translations were mainly undertaken by teams of Chinese and foreign translators in the Foreign Languages Press (FLP) in Beijing. This paper aims to explore how literary translation was used for nation branding and promoting Chinese communism abroad. It reveals the political agenda behind the outward translation activity. It goes on to probe into the patronage of the FLP to disclose the relationship between the translating institution and the political discourse on the nation. Lastly, the study of the English translation of Linhai Xueyuan (林海雪原), i.e. Tracks in the Snowy Forest, a bestseller representative of the ‘revolutionary novel’ of the time, will show that the adaptations aim at recasting revolutionary characters as “perfect” heroes so as to project an ideal image of the modern Chinese nation. The paper concludes with a call to integrate outward translation into TS. Based on Luhmann’s sociology of communication it provides a preliminary observation on the reception of the PRC’s export enterprise, which, more often than not, turned out to be counterproductive.
Linguistic evaluation of translation errors in Chinese–English machine translations of patent titles
Authors: Tsai Yvonne 
Published: August 2017

Abstract
The title of an invention allows the reader to understand the significance of a patent claim, and the wording of the title recurs throughout the subsequent patent documentation. If the translation of the title is erroneous, the quality of the translation in other parts of the patent documentation also suffers. This research involved using linguistic evaluation to identify common translation errors in Chinese–English machine translations of patent titles and examine the quality of machine-translated patent titles. Special focus was placed on orthographic, morphological, lexical, semantic, and syntactic errors found in patent titles. We sought to answer the following questions: (1) What are the trends in the application of machine translation in the Taiwan Intellectual Property Office (TIPO)? (2) How is the quality of machine translation controlled at TIPO? (3) What are common errors in machine-translated patent titles? Through analysis of our findings, it is possible to estimate the level of effort required from a posteditor following translation, and to suggest methods of improving machine translations of patent titles. This study also generates information applicable to the training of patent translators and posteditors.
Expression of a Vibrio parahaemolyticus toxin in Escherichia coli results in chromosomal DNA degradation
Authors: Zhang Jing , Taniguchi Saki , Ito Hironori , Iiyama Kazuhiro , Hino Madoka , Katayama Tsutomu , Kimura Makoto 
Published: August 2017

Abstract
A toxin-antitoxin system, vp1842/vp1843, locates within a superintegron on the Vibrio parahaemolyticus genome chromosome I whose toxin gene vp1843 encodes a DNA nicking endonuclease. We found that the vp1843 expression in Escherichia coli cells strongly induced chromosomal DNA degradation. On the basis of these observations, we discuss a possible physiological role of vp1842/vp1843 in V. parahaemolyticus.
Panel Effects and Opinion Crafting in the US Courts of Appeals
Authors: Hinkle Rachael K. 
Published: August 2017

AbstractScholars have observed that federal circuit judges’ voting behavior can be influenced by even a single colleague on a three-judge panel. I explore whether such forces extend beyond voting to affect how circuit judges use binding precedent to develop circuit law, by examining whether the role of ideology is dampened when a judge writes for a panel that includes one or two colleagues from a different party. Using an original data set of published search-and-seizure opinions from 1953 to 2010, I uncover evidence that panel effects do extend beyond voting to influence opinion drafting as well.
Strategic Retirement in Comparative Perspective: Supreme Court Justices in Presidential Regimes
Authors: Pérez-Liñán Aníbal , Araya Ignacio Arana 
Published: August 2017

AbstractStudents of judicial behavior debate whether justices time their retirement to allow for the nomination of like-minded judges. We formalize the assumptions of strategic retirement theory and derive precise hypotheses about the conditions that moderate the effect of partisan incentives on judicial retirements. The empirical implications are tested with evidence for Supreme Court members under democracies and dictatorships in six presidential regimes between 1900 and 2004. The theory of strategic retirement finds limited support in the United States and elsewhere. We conclude that researchers should emphasize “sincere” motivations for retirement, progressive political ambitions, and—crucial in weakly institutionalized legal systems—political pressures.
Electron emission from water molecule in collisions with fast highly charged C, O and Si-ions and scaling law
Authors: Bhattacharjee S. , Bagdia C. D. , Chowdhury M. R. , Monti J. , Rivarola R. D. , Misra D. , Tribedi L. C. 
Published: August 2017

Synopsis
Double differential cross sections (DDCS) of vapor phase water molecules by similar velocity C6+, O8+ and Si13+ ion impact have been measured by the electron spectroscopy technique. The total ionization cross sections (TCS) were obtained by numerical integration of the DDCS results. All the existing data have been plotted after scaling. Gradual deviation of the TCS from the first Born predicted qp
2–scaling has been observed.
Selection Effects and Heterogeneous Demand Responses to the Berkeley Soda Tax Vote
Authors: Debnam Jakina 
Published: August 2017

AbstractEarly evidence from household‐level surveys suggests that the one‐cent‐per‐ounce tax on sugar‐sweetened beverages that took effect on March 1, 2015, in Berkeley, California, has decreased consumption of sugar‐sweetened beverages dramatically. Even if these findings are robust, the public policy implications of expanding the Berkeley soda tax policy to a national level are complicated by selection effects inherent in the populations of both voters and consumers. We find that consumption responses related to the tax interact nontrivially with consumer heterogeneity. Some of these responses directly counter the public policy goals of a soda tax. For example, high‐consuming households are less price sensitive and therefore less responsive to price changes following a tax. Further, “reactance” among high‐consuming populations led to increases in soda consumption immediately following the passage of the tax, partially mitigating reductions in soda consumption.
Implementing electronic health records (EHRs): health care provider perceptions before and after transition from a local basic EHR to a commercial comprehensive EHR
Authors: Krousel-Wood Marie , McCoy Allison B , Ahia Chad , Holt Elizabeth W , Trapani Donnalee N , Luo Qingyang , Price-Haywood Eboni G , Thomas Eric J , Sittig Dean F , Milani Richard V 
Published: August 2017

AbstractObjectiveWe assessed changes in the percentage of providers with positive perceptions of electronic health record (EHR) benefit before and after transition from a local basic to a commercial comprehensive EHR.MethodsChanges in the percentage of providers with positive perceptions of EHR benefit were captured via a survey of academic health care providers before (baseline) and at 6–12 months (short term) and 12–24 months (long term) after the transition. We analyzed 32 items for the overall group and by practice setting, provider age, and specialty using separate multivariable-adjusted random effects logistic regression models.ResultsA total of 223 providers completed all 3 surveys (30% response rate): 85.6% had outpatient practices, 56.5% were &gt;45 years old, and 23.8% were primary care providers. The percentage of providers with positive perceptions significantly increased from baseline to long-term follow-up for patient communication, hospital transitions – access to clinical information, preventive care delivery, preventive care prompt, preventive lab prompt, satisfaction with system reliability, and sharing medical information (P &lt; .05 for each). The percentage of providers with positive perceptions significantly decreased over time for overall satisfaction, productivity, better patient care, clinical decision quality, easy access to patient information, monitoring patients, more time for patients, coordination of care, computer access, adequate resources, and satisfaction with ease of use (P &lt; 0.05 for each). Results varied by subgroup.ConclusionAfter a transition to a commercial comprehensive EHR, items with significant increases and significant decreases in the percentage of providers with positive perceptions of EHR benefit were identified, overall and by subgroup.
Facing Dominance: Anthropomorphism and the Effect of Product Face Ratio on Consumer Preference
Authors: Maeng Ahreum , Aggarwal Pankaj 
Published: August 2017

AbstractA product’s front face (e.g., a watch face or car front) is typically the first point of contact and a key determinant of a consumer’s initial impression about the product. Drawing on evolutionary accounts of human face perception suggesting that the face width-to-height ratio (fWHR: bizygomatic width divided by upper-face height) can signal dominance and affect its overall evaluation, this research is based on the premise that product faces are perceived in much the same way as human faces. Five experiments tested this premise. Results suggest that like human faces, product faces with high (vs. low) fWHR are perceived as more dominant. However, while human faces with high fWHR are liked less, product faces with high fWHR are liked more as revealed by consumer preference and willingness-to-pay scores. The greater preference for the high fWHR product faces is motivated by the consumers’ desire to enhance and signal their own dominant status as evidenced by the moderating effects of type of goal and of usage context. Brand managers and product designers may be particularly interested in these findings since a simple design feature can have potentially significant marketplace impact, as was also confirmed by the field data obtained from secondary sources.
Cancer mortality in residents of the terrain-shielded area exposed to fallout from the Nagasaki atomic bombing
Authors: Yokota Kenichi , Mine Mariko , Kondo Hisayoshi , Matsuda Naoki , Shibata Yoshisada , Takamura Noboru 
Published: August 2017

Abstract
The health effects of radiation exposure from the atomic bomb fallout remain unclear. The objective of the present study is to elucidate the association between low-dose radiation exposure from the atomic bomb fallout and cancer mortality among Nagasaki atomic bomb survivors. Of 77 884 members in the Nagasaki University Atomic Bomb Survivors Cohort, 610 residents in the terrain-shielded area with fallout were selected for this analysis; 1443 residents in the terrain-shielded area without fallout were selected as a control group; and 3194 residents in the direct exposure area were also selected for study. Fifty-two deaths due to cancer in the terrain-shielded fallout area were observed during the follow-up period from 1 January 1970 to 31 December 2012. The hazard ratio for cancer mortality in the terrain-shielded fallout area was 0.90 (95% confidence interval: 0.65–1.24). No increase in the risk of cancer mortality was observed, probably because the dose of the radiation exposure was low for residents in the terrain-shielded fallout areas of the Nagasaki atomic bomb, and also because the number of study subjects was small.
Accelerated tidal circularization via resonance locking in KIC 8164262
Authors: Fuller Jim , Hambleton Kelly , Shporer Avi , Isaacson Howard , Thompson Susan 
Published: August 2017

Abstract
Tidal dissipation in binary star and planetary systems is poorly understood. Fortunately, eccentric binaries known as heartbeat stars often exhibit tidally excited oscillations, providing observable diagnostics of tidal circularization mechanisms and time-scales. We apply tidal theories to observations of the heartbeat star KIC 8164262, which contains an F-type primary in a very eccentric orbit that exhibits a prominent tidally excited oscillation. We demonstrate that the prominent oscillation is unlikely to result from a chance resonance between tidal forcing and a stellar oscillation mode. However, the oscillation has a frequency and amplitude consistent with the prediction of resonance locking, a mechanism in which coupled stellar and orbital evolution maintain a stable resonance between tidal forcing and a stellar oscillation mode. The resonantly excited mode produces efficient tidal dissipation (corresponding to an effective tidal quality factor Q ∼ 5 × 104), such that tidal orbital decay/circularization proceeds on a stellar evolution time-scale.
The quasar luminosity function at redshift 4 with the Hyper Suprime-Cam Wide Survey
Authors: Akiyama Masayuki , He Wanqiu , Ikeda Hiroyuki , Niida Mana , Nagao Tohru , Bosch James , Coupon Jean , Enoki Motohiro , Imanishi Masatoshi , Kashikawa Nobunari , Kawaguchi Toshihiro , Komiyama Yutaka , Lee Chien-Hsiu , Matsuoka Yoshiki , Miyazaki Satoshi , Nishizawa Atsushi J , Oguri Masamune , Ono Yoshiaki , Onoue Masafusa , Ouchi Masami , Schulze Andreas , Silverman John D , Tanaka Manobu M , Tanaka Masayuki , Terashima Yuichi , Toba Yoshiki , Ueda Yoshihiro 
Published: August 2017

Abstract
We present the luminosity function of z ∼ 4 quasars based on the Hyper Suprime-Cam Subaru Strategic Program Wide layer imaging data in the g, r, i, z, and y bands covering 339.8 deg2. From stellar objects, 1666 z ∼ 4 quasar candidates are selected via the g-dropout selection down to i = 24.0 mag. Their photometric redshifts cover the redshift range between 3.6 and 4.3, with an average of 3.9. In combination with the quasar sample from the Sloan Digital Sky Survey in the same redshift range, a quasar luminosity function covering the wide luminosity range of M1450 = −22 to −29 mag is constructed. The quasar luminosity function is well described by a double power-law model with a knee at M1450 = −25.36 ± 0.13 mag and a flat faint-end slope with a power-law index of −1.30 ± 0.05. The knee and faint-end slope show no clear evidence of redshift evolution from those seen at z ∼ 2. The flat slope implies that the UV luminosity density of the quasar population is dominated by the quasars around the knee, and does not support the steeper faint-end slope at higher redshifts reported at z &gt; 5. If we convert the M1450 luminosity function to the hard X-ray 2–10 keV luminosity function using the relation between the UV and X-ray luminosity of quasars and its scatter, the number density of UV-selected quasars matches well with that of the X-ray-selected active galactic nuclei (AGNs) above the knee of the luminosity function. Below the knee, the UV-selected quasars show a deficiency compared to the hard X-ray luminosity function. The deficiency can be explained by the lack of obscured AGNs among the UV-selected quasars.
Novel molecular defects associated with very early-onset inflammatory bowel
Authors: Ciullini Mannurita Sara , Gambineri Eleonora 
Published: August 2017

Purpose of review
Immune dysregulation disorders present with common clinical features of multiorgan autoimmunity. Gastrointestinal involvement is the hallmark of an impaired immune homeostasis. This review will give an overview on the novel phenotypes, highlighting the major points that will help to enable early diagnosis and treatment.

Recent findings
The rapid progress on DNA sequencing technologies have led to the identification of monogenic defects that adversely impact the control of immune homeostasis. Lymphocytes may be present but dysfunctional, allowing for the development of excessive autoreactivity and resultant autoimmune disease. Regulatory T cells (Tregs) play an essential role in enforcing immune tolerance. Here we illustrate disorders caused by impairment of mechanisms ensuring Tregs function (Tregs related) in which autoimmunity is a hallmark of the clinical disease presentation and other disorders, affecting molecules more broadly involved in immune responses and indirectly causing immune dysregulation (Tregs unrelated). Clinical presentation is sometime mischievous and often symptoms are analogous in different diseases and can mislead diagnosis.

Summary
The increasing comprehension of immunological concepts behind immune dysregulation diseases will allow better and in some cases possibly even targeted treatment. A genetic diagnosis therefore becomes important information in this group of patients, especially as some patients might require hematopoietic stem cell transplantation.
Presentation Coagulopathy and Persistent Acidosis Predict Complications in Orthopaedic Trauma Patients
Authors: Childs Benjamin R. , Verhotz Daniel R. , Moore Timothy A. , Vallier Heather A. 
Published: August 2017

Objectives:
To evaluate the ability of measures of coagulopathy and acidosis to predict complications. We hypothesize that increased coagulopathy and acidosis over the first 60 hours of hospitalization will result in increased rates of infection and mortality.

Design:
Prospective, observational.

Setting:
Level 1 trauma center.

Patients:
Three hundred seventy-six skeletally mature patients with an Injury Severity Score greater than 16, who were surgically treated for high-energy fractures of the femur, pelvic ring, acetabulum, and/or spine.

Main Outcome Measurements:
Data included measures of acidosis, pH, lactate, and base excess, and measures of coagulopathy, Prothrombin (PT), Partial Throunboplastin Time (PTT), International Normalized Ratio (INR), and platelets. Complications including pneumonia, deep venous thrombosis, pulmonary embolism, infection, organ failure, acute renal failure, sepsis, and death were documented.

Results:
Acidosis was common on presentation (88.8%) and decreased over 48 hours (50.4%). Incidence of coagulopathy increased over 48 hours (16.3%–34.3%). Coagulopathy on presentation was associated with complications (54.0% vs. 27.7%) including pneumonia, acute renal failure, multiple organ failure, infection, sepsis, and death. Acidosis was associated with complications if it persisted later in the hospital course.

Conclusion:
Coagulopathy on presentation is a stronger predictor of complications, sepsis, and death than acidosis. During the first 48 hours, unresolved acidosis increased the risk of complications and sepsis. Complications were most related to higher Injury Severity Score.

Level of Evidence:
Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.