bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and Characterization of Graphene Oxide‐Grafted Hexadecanol Composite Phase‐Change Material for Thermal Energy Storage
Authors: Wang Yi , Liu Zhou , Zhang Ting , Zhang Zhengfei 
Published: April 2017

AbstractWith the aim of improving the shape stability and recycling reliability of hexadecanol (HD), graphene oxide (GO)‐grafted hexadecanol (GO‐g‐HD) shape‐stabilized phase‐change material (SSPCM) with good thermochemical properties was prepared by oxidizing graphite powders to form GO, which was converted into the acyl chloride and finally condensed with HD. Various characterization techniques were employed to investigate the microstructure, thermal properties, thermal durability, and reliability of the composite. The results show that HD was embedded in the composite with a maximum mass fraction of 62.7 wt % through physical adsorption and covalent bonding. The grafted percentage and density of HD on ultrathin GO sheets are 36.5 wt % and 1.51 mmol g−1, respectively. The GO‐g‐HD SSPCM melts at 49.7 °C with a latent heat of 152.3 J g−1, and freezes at 45.4 °C with a phase‐change enthalpy of 129.9 J g−1. The thermal conductivity of GO‐g‐HD is measured as 0.519 W m−1 K−1, which is an improvement of 41.8 % compared with that of neat HD. Moreover, the as‐prepared composite also presents excellent chemical and thermal stability, excellent thermal durability, negligible variation in latent heats, and no changes in the phase‐change temperatures due to strong covalent bonds and interactions between the matrix and HD. Thus, GO‐g‐HD is a promising candidate for thermal energy storage in the future because of the very good latent heat, enhanced conductivity, and stability.
HSPA8 as a novel fusion partner of NR4A3 in extraskeletal myxoid chondrosarcoma
Authors: Urbini Milena , Astolfi Annalisa , Pantaleo Maria Abbondanza , Serravalle Salvatore , Dei Tos Angelo Paolo , Picci Piero , Indio Valentina , Sbaraglia Marta , Benini Stefania , Righi Alberto , Gambarotti Marco , Gronchi Alessandro , Colombo Chiara , Dagrada Gian Paolo , Pilotti Silvana , Maestro Roberta , Polano Maurizio , Saponara Maristella , Tarantino Giuseppe , Pession Andrea , Biasco Guido , Casali Paolo Giovanni , Stacchiotti Silvia 
Published: April 2017

AbstractExtraskeletal myxoid chondrosarcoma (EMC) is a very rare sarcoma most often arising in the soft tissue. Rare EMC of the bone have been reported. EMC exhibits distinctive clinico‐pathological and genetic features; however, despite the name, it lacks any feature of cartilaginous differentiation. EMC is characterized by the rearrangement of the NR4A3, which, in most cases (about 62‐75%), is fused with EWSR1 and less frequently with other partners, including TAF15 (27%), TCF12 (4%), TFG, and FUS. We herein report the identification by whole‐transcriptome sequencing of HSPA8 as a novel fusion partner of NR4A3 in a case of EMC. FISH analysis confirmed the presence of a genomic HSPA8‐NR4A3 translocation in the vast majority of tumor cells. Our findings expand the spectrum of NR4A3 fusion partners involved in EMC pathobiology.
Numerical study of convective heat transfer in T‐bifurcating channel
Authors: Lakehal A. , Nait Bouda N. , Harmand S. 
Published: April 2017

AbstractA numerical study of a three‐dimensional turbulent flow in a rectangular T‐bifurcating duct was performed. It focused on the analysis of heat transfer in the branching duct at 90 to the main flow. Including separation and reattachment phenomena, the flow seemed to be anisotropic. The closure system of the full set of Navier–Stokes equations governing the flow was based on the on one point statistical modeling using a low Reynolds number second‐order full stress transport model. For several aspect ratios, results show that in addition to the recirculation zone in the branching duct close to the upstream side; pairs of streamwise vortices were generated downstream of the junction zone with their centers moving towards the symmetry plane. The effect of the aspect ratio of the branching section in enhancing this phenomenon and flow rate effect on the heat transfer were particularly analyzed in this paper.
Study of three‐dimensional natural convection and entropy generation in an inclined solar collector equipped with partitions
Authors: Yejjer Olfa , Kolsi Lioua , Aich Walid , Al‐Rashed Abdullah A.A.A. , Borjini Mohamed Naceur , Ben Aissia Habib 
Published: April 2017

AbstractThree‐dimensional natural convection in an inclined solar collector equipped with partitions has been investigated numerically. The presence of partitions improves the performances of the collector by increasing the heat transfer near the absorber. A parametric study was done for various partitions length and Rayleigh numbers, while Prandtl number and inclination angle were fixed at 0.71 and 45°, respectively. Results are reported in terms of isosurfaces of temperature, isotherms, particles trajectories, velocity vector projection, average Nusselt number along the absorber plate and entropies generation contours.
UTILIZING MBSE PATTERNS TO ACCELERATE SYSTEM VERIFICATION
Authors: Cook David , Schindel William D. 
Published: April 2017

ABSTRACTIn aerospace, automotive, healthcare, and other domains, the capability to effectively plan and perform system verification tests is increasingly a strategic differentiator. This paper reports on methods used to improve effectiveness of complex aircraft system tests, the gains achieved, and their connection to underlying methods and trends. These include use of model‐based systems engineering (MBSE), leveraged by pattern‐based systems engineering (PBSE) to generate configurable, reusable system models — the focus of the INCOSE MBSE Patterns Challenge Team (Patterns Challenge Team 2013‐2015). Distinctive aspects include (1) use of configurable, model‐based patterns of system descriptions, including configurable system verification tests, (2) improved ability of model‐based descriptions to integrate modeling tools and automated systems for test management, (3) use of models to describe both the system under development and the development process, and (4) ability of these models to be integrated with other system lifecycle management processes and information systems, for increased leverage.
Kinetic modelling of the glycerol oxidation in the liquid phase: comparison of Pt, Au and Ag AS active phases
Authors: Díaz José Antonio , Skrzyńska Elżbieta , Zaid Soraya , Girardon Jean‐Sébastien , Capron Mickaël , Dumeignil Franck , Fongarland Pascal 
Published: April 2017

AbstractBACKGROUNDUnlike Pt and Au, Ag has recently been reported to be an active catalyst for the synthesis of glycolic acid from the liquid phase oxidation of glycerol (GLY). In order to provide comparative information about the kinetics of this reaction using Pt, Au or Ag, a kinetic model was derived for each catalyst (Ag/, Pt/ and Au/Al2O3), using the experimental results obtained at different temperatures.RESULTSA power‐law kinetic model was proposed for each catalyst, which included the Khang–Levenspiel model to evaluate potential catalyst deactivation. All three kinetic models predicted well the experimental concentrations. Pt/ and Au/Al2O3 showed higher kinetic rate constants, the highest being that of the production of glyceric acid. The lower the metal particle size, the higher the kinetic rate constant of the production of glyceric acid was. Deactivation parameters played an important role in the model of Pt/Al2O3, so that Au/ and Ag/Al2O3 seemed to be more resistant to deactivation.CONCLUSIONSThis work reports the first kinetic model for the oxidation of GLY using an Ag‐based catalyst. It showed a noticeable kinetic rate constant for the production of glycolic acid. The activation energies obtained were in the range 48–97 kJ mol−1. © 2017 Society of Chemical Industry
Breath‐hold and free‐breathing 2D phase‐contrast MRI for quantification of oxygen‐induced changes of pulmonary circulation dynamics in healthy volunteers
Authors: Czerner Christoph P. , Winther Hinrich B. , Zapf Antonia , Wacker Frank , Vogel‐Claussen Jens 
Published: April 2017

PurposeTo evaluate the effect of inhaled 100% oxygen on pulmonary circulation dynamics in healthy volunteers using 2D phase‐contrast magnetic resonance imaging (2D PC MRI).Materials and MethodsTwenty‐one healthy volunteers were examined at 1.5T. Through‐plane 2D PC MRI measurements were performed in the main pulmonary artery during free‐breathing and breath‐hold. Acceleration time and volume, maximum and minimum area, area change, average and maximum mean velocity, forward volume, heart rate, as well as blood pressure were determined. At baseline, subjects breathed room air. After application of a closed‐fit full face mask, three further measurements were conducted: at room air (control), directly after starting 15 L/min 100% oxygen (wash‐in), and after 5 minutes during continuous oxygen supply (saturation). Data were analyzed with a mixed linear model. Skewed distributed variables were rank‐transformed. Tukey contrasts with family‐wise adjusted P‐values were applied for pairwise comparisons.ResultsInhaled oxygen affected several hemodynamic parameters. Average mean velocity (P < 0.01: breath‐hold during wash‐in and saturation, P = 0.03: free‐breathing during saturation) and maximum mean velocity (P < 0.01: breath‐hold and free‐breathing during saturation) decreased. When obtained during free‐breathing, acceleration volume (P = 0.02: saturation), area change (P = 0.02: saturation), and maximum area (P = 0.02: wash‐in, P = 0.03: saturation) increased, while minimum area and forward volume did not change.ConclusionOxygen alters pulmonary circulation dynamics in the main pulmonary artery of healthy volunteers, which can be reliably detected using 2D phase‐contrast MRI.Level of Evidence: 2Technical Efficacy: Stage 1J. Magn. Reson. Imaging 2017;46:1698–1706.
Shift in MONSOON–SST teleconnections in the tropical Indian Ocean and ENSEMBLES climate models' fidelity in its simulation
Authors: Pradhan Maheswar , Yadav Ramesh Kumar , Ramu Dandi A. , Srivastava Ankur , Phani M. K. , Rao Suryachandra A. 
Published: April 2017

ABSTRACTThe climate shift in 1976–1977 sets a clear distinction in the teleconnection between Indian summer monsoon rainfall (ISMR) and sea surface temperatures (SST) in the tropical oceans, particularly in the tropical Indian Ocean (TIO). Before the climate shift (Pre‐77), the observed correlation between ISMR and SST was positive in the eastern equatorial Indian Ocean (EIO) and negative correlation prevailed in the western equatorial Indian Ocean (WIO), whereas after the climate shift (Post‐77), the correlation pattern has reversed (i.e. positive correlation in WIO and negative correlation in EIO). The major reason for this shift is the consistent warming of SSTs throughout the tropics and frequent occurrence of IOD events. Further, it is noticed that during the earlier decades, the Indian Ocean was responding to the atmospheric forcing, particularly along the axis of strong cross equatorial flow, whereas in the recent decades, Indian Ocean dynamics are playing a crucial role in determining the SST in major parts of the Indian Ocean particularly in the EIO. Seasonal re‐forecasts from six state‐of‐the‐art global coupled atmosphere–ocean climate models which participated in ENSEMBLES faithfully capture the pre‐77 dipole structure of correlations. But the post‐77 correlation pattern is not simulated by any of the six models considered in this study. Two possible reasons are pointed out for the models' inability to capture the reversal of teleconnection: (1) in the coupled models, unchanged mean state of the winds inhibits ISMR to be governed by coupled dynamics in the TIO; (2) the strong, local SST–rainfall relationship in models even in post‐77 period limits the influence of the teleconnections on the ISMR.
Effect of oak wood barrel capacity and utilization time on phenolic and sensorial profile evolution of an Encruzado white wine
Authors: Nunes Paulo , Muxagata Sara , Correia Ana C , Nunes Fernando M , Cosme Fernanda , Jordão António M 
Published: April 2017

AbstractBACKGROUNDSeveral studies have reported the influence of diverse winemaking technologies in white wine characteristics. However, the impact of the use of different oak wood barrel capacities and utilization time on the evolution of white wine phenolic content and sensorial characteristics are not usually considered. Thus the aim of this work was to evaluate the effect of oak wood barrel capacity and utilization time on the evolution of phenolic compounds, browning potential index and sensorial profile of an Encruzado white wine.RESULTSFor the 180 aging days considered, the use of new oak wood barrels induced a greater increase in global phenolic composition, including several individual compounds, such as gallic and ellagic acid, independently of the barrel capacity. Tendency for a lesser increase of the browning potential index values was detected for white wines aged in new oak wood barrels. The sensorial profile evolution, showed significant differences only for the aroma descriptors, namely for ‘wood aroma’ and ‘aroma intensity’, white wine aged in 225 L new oak wood barrels being the highest scored.CONCLUSIONThe results show that, in general, the use of different capacities and utilization time of oak wood barrels used for white wine aging could play an important role in white wine quality. © 2017 Society of Chemical Industry
Restoration of Gypsicolous Vegetation on Quarry Slopes: Guidance for Hydroseeding under Contrasting Inclination and Aspect
Authors: Ballesteros Miguel , Cañadas Eva María , Marrs Rob H. , Foronda Ana , Martín‐Peinado Francisco José , Lorite Juan 
Published: April 2017

AbstractThe establishment of gypsicolous vegetation of high conservation value on land impacted by quarrying requires restoration measures to overcome constraints imposed by the new landforms created in the process. The aim of this study was to assess the suitability of three standard hydroseeding methods to restore gypsicolous vegetation on quarry spoil slopes under a dry Mediterranean climate. The treatments were as follows: paper cellulose mulch, paper cellulose mulch + organic blanket, and wood fibre mulch, compared against a control. These treatments were tested on two slopes (10–15% vs 60–65%) and two contrasting aspects (north vs south). We evaluated the cover of all plant species 2·8 years after treatment, assessing both target gypsicolous species and non‐target species. Our results showed strong compositional and cover differences between hydroseeded and control plots. Control plots had a low cover of target species with a vegetation composed of early‐successional species that had the potential to hinder target species establishment over time. All hydroseeding treatments improved target vegetation cover, with wood fibre performing best in most situations studied here, alternatives being the cheaper but less effective paper mulch on shallow slopes, or the more expensive paper mulch + blanket on steep slopes in case of high erosion risk. Shallow and southern‐steep slopes were more suitable for the recovery of gypsum vegetation by hydroseeding, compared to northern‐steep slopes where non‐target species developed more readily outcompeting target species. These results will help to guide management decisions to restore gypsicolous vegetation by hydroseeding in disturbed gypsum habitats. Copyright © 2017 John Wiley & Sons, Ltd.
Immunomodulatory Nanomedicine
Authors: Bartneck Matthias 
Published: April 2017

AbstractImmunity has a major impact on inflammatory diseases and cancer, and biologics targeting immune cells and their factors reach a quarter trillion of market volume by this year. Adaptive leukocytes have recently been engaged in cancer immunotherapy, whereas modulation of the innate immune cells, specifically macrophages, is expected as next breakthrough. With patents of major biologics expiring, nanomedicine has the potential to substitute therapeutic proteins by using miniaturized macromolecules. This review includes an overview on the involvement of major immune cell types into disease and a summary on selected current therapies based on biologics and small molecules. Novel developments in nanomedicine‐based immunotherapies, including associated chances and risks, are presented.
image
Effects of concentration and vendor specific composition of formalin on postmortem MRI of the human brain
Authors: Birkl Christoph , Soellradl Martin , Toeglhofer Anna Maria , Krassnig Stefanie , Leoni Marlene , Pirpamer Lukas , Vorauer Thomas , Krenn Heinz , Haybaeck Johannes , Fazekas Franz , Ropele Stefan , Langkammer Christian 
Published: April 2017

PurposeFormalin fixation prevents tissue autolysis by crosslinking proteins and changes tissue microstructure and MRI signal characteristics. Previous studies showed high variations in MR relaxation time constants of formalin fixed brain tissue, which has been attributed to the use of different formalin concentrations. Our investigations confirmed the influence of formalin concentration on relaxation times and unexpectedly revealed an influence of vendor specific formalin composition, which has not been investigated so far.MethodsWe systematically analyzed relaxation times of human brain tissue fixed with 4% and 10% formalin compared with unfixed condition at 3 Tesla MRI. Furthermore, we assessed relaxation times of nine formalin solutions from different vendors and performed comparisons of their magnetic susceptibility by SQUID (superconducting quantum interference device) magnetometry.ResultsTissue relaxation times decreased approximately twice as fast using 10% than in 4% formalin fixation. The vendor specific composition of the formalin solutions and concentration dependent paramagnetic effects showed a substantial contribution to differences in relaxation times of formalin.ConclusionOur study demonstrates that differences of the formalin composition have substantial effects on MRI signal characteristics after fixation, which can explain the divergence of reported relaxation times beyond the effect of differences in formalin concentration. Magn Reson Med 79:1111–1115, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Innovative approaches to weight loss in a high‐risk population: The small changes and lasting effects (SCALE) trial
Authors: Phillips Erica G. , Wells Martin T. , Winston Ginger , Ramos Rosio , Devine Carol M. , Wethington Elaine , Peterson Janey C. , Wansink Brian , Charlson Mary 
Published: April 2017

ObjectiveTo evaluate the efficacy of a small change behavioral weight loss intervention with or without a positive affect/self‐affirmation (PA/SA) component on weight loss at 12 months.MethodsBlack and Hispanic adults (N = 405) with body mass index 25‐50 kg/m2 selected one of ten small change eating strategies and a physical activity goal, randomly with/without PA/SA. Participants were followed by community health workers at set intervals (weekly in months 1‐3; biweekly in months 4‐9; once monthly in months 10‐12).ResultsThere was no difference in weight loss at 12 months between participants in the small change approach alone (1.1%) versus the small change PA/SA intervention (1.2%). During treatment, 9% of participants lost at least 7% of their initial body weight. Participants who reported more interval life events had a lower likelihood of losing weight (P < 0.0001). However, those randomized to the small change PA/SA intervention gained less weight (+0.3% vs. 2.3% gain; P < 0.0001).ConclusionsThe small change PA/SA intervention did not lead to a significant difference in weight loss in comparison to the small change approach alone. It did, however, decrease the negative impact of psychosocial stressors on weight gain among participants with more interval life events.
Neutron dose distribution in the treatment room for an accelerator in the flattening filter‐free mode
Authors: Li Dingjie , Deng Xiaowu , Xue Ying , Lou Zhaoyang , Zhang Yougai , Guo Wei , Wang Jianhua 
Published: April 2017

AbstractObjectiveTo provide specific data and to make recommendations for radiation protection for clinical applications, the neutron cumulative dose, and exposure time in the treatment room around an accelerator operating at 10 MV in the conditions of both a conventional dose rate (with a flattening filter [FF] mode) and an ultra‐high dose rate (flattening filter‐free [FFF] mode) were measured and analyzed.MethodsIn the accelerator treatment room, the data were collected from four representative sites: the therapist's operating location, the distal end of the couch in the patient plane, the proximal maze, and the protective door. The field sizes were 5 × 5 cm2, 10 × 10 cm2, and 30 × 30 cm2; the output doses were 500 MU, 1000 MU, and 2000 MU; the solid water phantom simulating the patient's body was put on the isocenter; the dose rate in FF mode was a 10‐MV X‐ray at 600 MU/min; and the dose rate in FFF mode was 2400 MU/min. Under the same conditions, data were collected outside the selected area measuring three positions: the protective door, operating room, and center of the main protective wall position.ResultsThe neutron cumulative dose was negatively correlated with the field size; the closer to the target, the larger the neutron cumulative dose. The neutron cumulative dose was the largest at the distal end of the couch, and the neutron cumulative dose in FF mode was almost threefold as large as that in FFF mode. The neutron exposure time was positively correlated with the output dose. The FF mode takes slightly longer than the FFF mode. No neutron dose was read outside the accelerator room.ConclusionsOperating the accelerator in FFF mode will benefit both the patients and radiation therapists by reducing the neutron cumulative dose and exposure time. The current anti‐neutron accelerator room design is equally applicable to an ultra‐high‐dose rate (FFF) mode accelerator.
Diagnostic and therapeutic applications of tumor‐associated exosomes
Authors: Wang Ning , Xie Li 
Published: April 2017

AbstractExosomes are nanometric membrane vesicles released by almost all cell types. Their contents vary, and can include functional miRNA, mRNA, proteins, and lipids wrapped in a double layer of lipid membranes. Tumor‐derived exosomes interact with the tumor microenvironment, and are involved in tumor initiation, angiogenesis, invasion, and metastasis. Exosomes have abundant tumor‐specific molecules, with the potential to become new biomarkers for tumor diagnosis. Furthermore, an increasing number of studies use exosomes or their modified products as cell‐free vaccines and drug delivery carriers in oncotherapy. The present review focuses on the progress of exosomes in tumor diagnosis and therapies.
Crystal structure of a bicupin protein HutD involved in histidine utilization in Pseudomonas
Authors: Gerth M.L. , Liu Y. , Jiao W. , Zhang X.‐X. , Baker E.N. , Lott J.S. , Rainey P.B. , Johnston J.M. 
Published: April 2017

ABSTRACTCupins form one of the most functionally diverse superfamilies of proteins, with members performing a wide range of catalytic, non‐catalytic, and regulatory functions. HutD is a predicted bicupin protein that is involved in histidine utilization (Hut) in Pseudomonas species. Previous genetic analyses have suggested that it limits the upper level of Hut pathway expression, but its mechanism of action is unknown. Here, we have determined the structure of PfluHutD at 1.74 Å resolution in several crystallization conditions, and identified N‐formyl‐l‐glutamate (FG, a Hut pathway intermediate) as a potential ligand in vivo. Proteins 2017; 85:1580–1588. © 2017 Wiley Periodicals, Inc.