bluuebunny/crossref_metadata_2025_split huggingface dataset:
Altered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model
Authors: Obaldía III Nicanor , Dow Geoffrey S. , Gerena Lucia , Kyle Dennis , Otero William , Mantel Pierre-Yves , Baro Nicholas , Daniels Rachel , Mukherjee Angana , Childs Lauren M. , Buckee Caroline , Duraisingh Manoj T. , Volkman Sarah K. , Wirth Dyann F. , Marti Matthias 
Published: February 2016

AbstractInfections with Plasmodium falciparum, the most pathogenic of the Plasmodium species affecting man, have been reduced in part due to artemisinin-based combination therapies. However, artemisinin resistant parasites have recently emerged in South-East Asia. Novel intervention strategies are therefore urgently needed to maintain the current momentum for control and elimination of this disease. In the present study we characterize the phenotypic and genetic properties of the multi drug resistant (MDR) P. falciparum Thai C2A parasite strain in the non-human Aotus primate model, and across multiple passages. Aotus infections with C2A failed to clear upon oral artesunate and mefloquine treatment alone or in combination, and ex vivo drug assays demonstrated reduction in drug susceptibility profiles in later Aotus passages. Further analysis revealed mutations in the pfcrt and pfdhfr loci and increased parasite multiplication rate (PMR) across passages, despite elevated pfmdr1 copy number. Altogether our experiments suggest alterations in parasite population structure and increased fitness during Aotus adaptation. We also present data of early treatment failures with an oral artemisinin combination therapy in a pre-artemisinin resistant P. falciparum Thai isolate in this animal model.
Dynamic changes in protein interaction between AKAP95 and Cx43 during cell cycle progression of A549 cells
Authors: Chen Xiaoxuan , Kong Xiangyu , Zhuang Wenxin , Teng Bogang , Yu Xiuyi , Hua Suhang , Wang Su , Liang Fengchao , Ma Dan , Zhang Suhui , Zou Xuan , Dai Yue , Yang Wei , Zhang Yongxing 
Published: February 2016

AbstractHere we show that A-kinase anchoring protein 95 (AKAP95) and connexin 43 (Cx43) dynamically interact during cell cycle progression of lung cancer A549 cells. Interaction between AKAP95 and Cx43 at different cell cycle phases was examined by tandem mass spectrometry(MS/MS), confocal immunofluorescence microscopy, Western blot, and co-immunoprecipitation(Co-IP). Over the course of a complete cell cycle, interaction between AKAP95 and Cx43 occurred in two stages: binding stage from late G1 to metaphase, and separating stage from anaphase to late G1. The binding stage was further subdivided into complex binding to DNA in interphase and complex separating from DNA in metaphase. In late G1, Cx43 translocated to the nucleus via AKAP95; in anaphase, Cx43 separated from AKAP95 and aggregated between two daughter nuclei. In telophase, Cx43 aggregated at the membrane of the cleavage furrow. After mitosis, Cx43 was absent from the furrow membrane and was located in the cytoplasm. Binding between AKAP95 and Cx43 was reduced by N-(2-[P-Bromocinnamylamino]-ethyl)-5-isoquinolinesulfonmide (H89) treatment and enhanced by Forskolin. dynamic interaction between AKAP95 and Cx43 varies with cell cycle progression to regulate multiple biological processes.
Are we failing to protect threatened mangroves in the Sundarbans world heritage ecosystem?
Authors: Sarker Swapan K. , Reeve Richard , Thompson Jill , Paul Nirmal K. , Matthiopoulos Jason 
Published: February 2016

AbstractThe Sundarbans, the largest mangrove ecosystem in the world, is under threat from historical and future human exploitation and sea level rise. Limited scientific knowledge on the spatial ecology of the mangroves in this world heritage ecosystem has been a major impediment to conservation efforts. Here, for the first time, we report on habitat suitability analyses and spatial density maps for the four most prominent mangrove species -Heritiera fomes, Excoecaria agallocha, Ceriops decandraandXylocarpus mekongensis. Globally endangeredH. fomesabundances declined as salinity increased. Responses to nutrients, elevation and stem density varied between species.H. fomesandX. mekongensispreferred upstream habitats.E. agallochaandC. decandrapreferred down-stream and mid-stream habitats. Historical harvesting had negative influences onH. fomes, C. decandraandX. mekongensisabundances. The established protected area network does not support the most suitable habitats of these threatened species. We therefore recommend a reconfiguration of the network to include these suitable habitats and ensure their immediate protection. These novel habitat insights and spatial predictions can form the basis for future forest studies and spatial conservation planning and have implications for more effective conservation of the Sundarbans mangroves and the many other species that rely on them.
Protective effects of genetic inhibition of Discoidin Domain Receptor 1 in experimental renal disease
Authors: Kerroch Monique , Alfieri Carlo , Dorison Aude , Boffa Jean-Jacques , Chatziantoniou Christos , Dussaule Jean-Claude 
Published: February 2016

AbstractChronic kidney disease is a progressive incurable pathology affecting millions of people. Intensive investigations aim to identify targets for therapy. We have previously demonstrated that abnormal expression of the Discoidin Domain Receptor 1 (DDR1) is a key factor of renal disease by promoting inflammation and fibrosis. The present study investigates whether blocking the expression of DDR1 after the initiation of renal disease can delay or arrest the progression of this pathology. Severe renal disease was induced by either injecting nephrotoxic serum (NTS) or performing unilateral ureteral obstruction in mice and the expression of DDR1 was inhibited by administering antisense oligodeoxynucleotides either at 4 or 8 days after NTS (corresponding to early or more established phases of disease, respectively), or at day 2 after ligation. DDR1 antisense administration at day 4 stopped the increase of proteinuria and protected animals against the progression of glomeruloneprhitis, as evidenced by functional, structural and cellular indexes. Antisense administration at day 8 delayed progression –but to a smaller degree- of renal disease. Similar beneficial effects on renal structure and inflammation were observed with the antisense administration of DDR1 after ureteral ligation. Thus, targeting DDR1 can be a promising strategy in the treatment of chronic kidney disease.
Discovery of Radioiodinated Monomeric Anthraquinones as a Novel Class of Necrosis Avid Agents for Early Imaging of Necrotic Myocardium
Authors: Wang Qin , Yang Shengwei , Jiang Cuihua , Li Jindian , Wang Cong , Chen Linwei , Jin Qiaomei , Song Shaoli , Feng Yuanbo , Ni Yicheng , Zhang Jian , Yin Zhiqi 
Published: February 2016

AbstractAssessment of myocardial viability is deemed necessary to aid in clinical decision making whether to recommend revascularization therapy for patients with myocardial infarction (MI). Dianthraquinones such as hypericin (Hyp) selectively accumulate in necrotic myocardium, but were unsuitable for early imaging after administration to assess myocardial viability. Since dianthraquinones can be composed by coupling two molecules of monomeric anthraquinone and the active center can be found by splitting chemical structure, we propose that monomeric anthraquinones may be effective functional groups for necrosis targetability. In this study, eight radioiodinated monomeric anthraquinones were evaluated as novel necrosis avid agents (NAAs) for imaging of necrotic myocardium. All131I-anthraquinones showed high affinity to necrotic tissues and131I-rhein emerged as the most promising compound. Infarcts were visualized on SPECT/CT images at 6 h after injection of131I-rhein, which was earlier than that with131I-Hyp. Moreover,131I-rhein showed satisfactory heart-to-blood, heart-to-liver and heart-to-lung ratios for obtaining images of good diagnostic quality.131I-rhein was a more promising “hot spot imaging” tracer for earlier visualization of necrotic myocardium than131I-Hyp, which supported further development of radiopharmaceuticals based on rhein for SPECT/CT (123I and99mTc) or PET/CT imaging (18F and124I) of myocardial necrosis.
Holey graphene frameworks for highly selective post-combustion carbon capture
Authors: Chowdhury Shamik , Balasubramanian Rajasekhar 
Published: February 2016

AbstractAtmospheric CO2 concentrations continue to rise rapidly in response to increased combustion of fossil fuels, contributing to global climate change. In order to mitigate the effects of global warming, development of new materials for cost-effective and energy-efficient CO2 capture is critically important. Graphene-based porous materials are an emerging class of solid adsorbents for selectively removing CO2 from flue gases. Herein, we report a simple and scalable approach to produce three-dimensional holey graphene frameworks with tunable porosity and pore geometry, and demonstrate their application as high-performance CO2 adsorbents. These holey graphene macrostructures exhibit a significantly improved specific surface area and pore volume compared to their pristine counterparts, and can be effectively used in post-combustion CO2 adsorption systems because of their intrinsic hydrophobicity together with good gravimetric storage capacities, rapid removal capabilities, superior cycling stabilities, and moderate initial isosteric heats. In addition, an exceptionally high CO2 over N2 selectivity can be achieved under conditions relevant to capture from the dry exhaust gas stream of a coal burning power plant, suggesting the possibility of recovering highly pure CO2 for long-term sequestration and/or utilization for downstream applications.
Resting-state functional connectivity between the dorsal anterior cingulate cortex and thalamus is associated with risky decision-making in nicotine addicts
Authors: Wei Zhengde , Yang Nannan , Liu Ying , Yang Lizhuang , Wang Ying , Han Long , Zha Rujing , Huang Ruiqi , Zhang Peng , Zhou Yifeng , Zhang Xiaochu 
Published: February 2016

AbstractNicotine addiction is associated with risky behaviors and abnormalities in local brain areas related to risky decision-making such as the dorsal anterior cingulate cortex (dACC), anterior insula (AI) and thalamus. Although these brain abnormalities are anatomically separated, they may in fact belong to one neural network. However, it is unclear whether circuit-level abnormalities lead to risky decision-making in smokers. In the current study, we used task-based functional magnetic resonance imaging (fMRI) and examined resting-state functional connectivity (RSFC) to study how connectivity between the dACC, insula and thalamus influence risky decision-making in nicotine addicts. We found that an increase in risky decision-making was associated with stronger nicotine dependence and stronger RSFC of the dACC-rAI (right AI), the dACC-thalamus, the dACC-lAI (left AI) and the rAI-lAI, but that risky decision-making was not associated with risk level-related activation. Furthermore, the severity of nicotine dependence positively correlated with RSFC of the dACC-thalamus but was not associated with risk level-related activation. Importantly, the dACC-thalamus coupling fully mediated the effect of nicotine-dependent severity on risky decision-making. These results suggest that circuit-level connectivity may be a critical neural link between risky decision-making and severity of nicotine dependence in smokers.
Serum n-3 polyunsaturated fatty acids and psychological distress in early pregnancy: Adjunct Study of Japan Environment and Children's Study
Authors: Hamazaki K , Harauma A , Otaka Y , Moriguchi T , Inadera H 
Published: February 2016

AbstractN-3 polyunsaturated fatty acids (PUFAs), especially long-chain types such as docosahexaenoic acid, are important nutrients in pregnancy, but the relationship between n-3 PUFA levels and perinatal and postnatal depression remains controversial. This study examined the possible relationship between serum n-3 PUFA levels and psychological distress among expectant mothers in early pregnancy. Data and specimen samples were obtained in a birth cohort study started at Toyama Regional Center in July 2012 as an adjunct study of the Japan Environment and Children’s Study. Blood samples were collected at 9–14 weeks’ gestation (75% of samples) or after 15 weeks (25%). Subjects with a Kessler Psychological Distress Scale score (K6) ⩾9 were assigned to the psychological distress group (n=283). The control group (n=283) was matched for age, educational level and family income. Fatty acid composition was determined from serum samples by gas chromatography. Associations between fatty acid levels and incident psychological distress were evaluated by logistic regression. After adjusting for possible confounders, eicosapentaenoic acid showed an inverse association with risk of psychological distress, with an odds ratio of 0.47 (95% confidence interval: 0.30, 0.73) for the highest tertile. This inverse association remained even after applying a higher cutoff score (K6 ⩾13) indicating severe psychological distress (74 pairs). We believe this is the first study to reveal the associations between serum n-3 PUFAs and risk of psychological distress in early pregnancy. Further research is required to verify the causality of these associations.
NPY+-, but not PV+-GABAergic neurons mediated long-range inhibition from infra- to prelimbic cortex
Authors: Saffari R , Teng Z , Zhang M , Kravchenko M , Hohoff C , Ambrée O , Zhang W 
Published: February 2016

AbstractAnxiety disorders are thought to reflect deficits in the regulation of fear memories. While the amygdala has long been considered a site of storage of fear memories, newer findings suggest that the prefrontal cortex (PFC) is essential in the regulation of amygdala-dependent memories and fear expression. Here, activation of the prelimbic cortex (PrL) enhances the expression of fear, while an elevated activity in the infralimbic cortex (IL) enhances fear extinction. Despite the presence of these facts, we still know very little about the synaptic interconnectivity within the PFC. The aim of the present study was to investigate the inhibitory circuits between prelimbic and IL using morphological and electrophysiological methods. Our immunohistochemical analysis revealed that the distribution of PV+- and NPY+-GABAergic neurons was strikingly different within the PFC. In addition, we provided the first experimental evidence that the pyramidal neurons in the PrL received a direct inhibitory input mediated by bipolar NPY+-GABAergic projection neurons in the IL. Deletion of the anxiety-related neuroligin 2 gene caused a decrease of this direct synaptic inhibition that originated from the IL. Thus, our data suggested that activation of the IL might not only directly activate the corresponding downstream anxiolytic pathway, but also suppress the PrL-related anxiogenic pathway and thus could differentially bias the regulation of fear expression and extinction.
The Use of Sound Level Meter Apps in the Clinical Setting
Authors: Fava Gaetano , Oliveira Gisele , Baglione Melody , Pimpinella Michael , Spitzer Jaclyn B. 
Published: February 2016

PurposeThe purpose of this study was to compare sound level meter (SLM) readings obtained using a Larson-Davis (Depew, NY) Model 831 Type 1 SLM, a RadioShack (Fort Worth, TX) SLM, and iPhone 5 (Apple, Cupertino, CA) SLM apps.MethodIn Procedure 1, pure tones were measured in an anechoic chamber (125, 250, 500, 1000, 2000, 4000, and 8000 Hz); sound pressure levels (SPLs) ranged from 60 to 100 dB SPL in 10-dB increments. In Procedure 2, human voices were measured. Participants were 20 vocally healthy adults (7 women, 13 men; mean age = 25.1 years). The task was to sustain a vowel “ah” at 3 intensity levels: soft, habitual, and loud. Microphones were lined up equal distances from the participant's mouth, and recordings were captured simultaneously.ResultsOverall, the 3 SLM apps and the RadioShack SLM yielded inconsistent readings compared with the Type 1 SLM.ConclusionThe use of apps for SPL readings in the clinical setting is premature because all 3 apps adopted were incomparable with the Type 1 SLM.
An adaptive dual-optimal path-planning technique for unmanned air vehicles
Authors: Whitfield Clifford A. 
Published: February 2016

A multi-objective technique for unmanned air vehicle path-planning generation through task allocation has been developed. The dual-optimal path-planning technique generates real-time adaptive flight paths based on available flight windows and environmental influenced objectives. The environmentally-influenced flight condition determines the aircraft optimal orientation within a downstream virtual window of possible vehicle destinations that is based on the vehicle’s kinematics. The intermittent results are then pursued by a dynamic optimization technique to determine the flight path. This path-planning technique is a multi-objective optimization procedure consisting of two goals that do not require additional information to combine the conflicting objectives into a single-objective. The technique was applied to solar-regenerative high altitude long endurance flight which can benefit significantly from an adaptive real-time path-planning technique. The objectives were to determine the minimum power required flight paths while maintaining maximum solar power for continual surveillance over an area of interest (AOI). The simulated path generation technique prolonged the flight duration over a sustained turn loiter flight path by approximately 2 months for a year of flight. The potential for prolonged solar powered flight was consistent for all latitude locations, including 2 months of available flight at 60° latitude, where sustained turn flight was no longer capable.
Decompressive Craniectomy for Viral Encephalitis: Two Case Reports
Authors: Caramanti Ricardo , Abib Eduardo , Moraes Dionei , Silva Eduardo , Rocha Carlos , Nogueira Fabiano 
Published: February 2016

AbstractA decompressive craniectomy is a therapeutic modality not commonly used in cases of refractory intracranial hypertension due to viral encephalitis. In this article the authors present two cases of patients with viral encephalitis that have undergone decompressive craniectomy to control intracranial pressure. Both evolved with Glasgow outcome score of 4. The main clinical data for the surgical decision are Glasgow coma scale and the pupils of the patient associated with the imaging tests showing a large necrotic area and perilesional edema. The evolution of the patients undergoing decompression was satisfactory in 92.3% of cases.
Enablers, challenges and relationships between research impact and theory generation
Authors: Holt Gary D. , Goulding Jack Steven , Akintoye Akintola 
Published: February 2016

Purpose
– Perceptions drawn from the construction management research (CMR) community regarding research impact (RI) and its relationship to theory generation (TG) are examined. Investigative emphasis is on RI and TG enablers and challenges (within an academic context). The paper aims to discuss these issues.

Design/methodology/approach
– Qualitative narrative data accrued from open-ended questions within a structured questionnaire survey are analysed using frequency, quantitative content analysis, and graphical methods. A model of the RI/TG interface is presented and discussed.

Findings
– Principal RI enablers are “facilitation” (industry engagement, time); while principal constraints include “internal factors” (the academic, the university) and “external factors” (collaboration, funding). Respective TG enablers are “resources” (competence, time, funding) and corresponding challenges include “external factors” (market forces, compliance). RI is considered a minor challenge to TG.

Research limitations/implications
– The study adds empirical evidence to the ongoing RI debate within the UK generally and with regard to the CMR discipline more specifically.

Originality/value
– RI research is relatively sparse, while the findings in regard to CMR are entirely novel.
Gender differences in preferences for firm characteristics across different groups of investors
Authors: Khan Mohammad Tariqul Islam , Tan Siow-Hooi , Chong Lee-Lee 
Published: February 2016

Purpose
– This paper aims to study gender differences in preferences for firm characteristics across various groups of investors in Malaysia.

Design/methodology/approach
– Self-declared preferences are elicited through a survey of 520 investors comprising retail, financial professionals and institutional investors in the Malaysian stock market. Non-parametric (Mann-Whitney and Kruskal-Wallis) tests are computed to achieve the stated objective.

Findings
– Results reveal that female investors display higher preferences for the liquidity of a firm, dividend payments, trading volume of a firm, stock price and firm’s age than male investors across investor’s groups.

Research limitations/implications
– Findings imply that the gender gap in investing behaviour can be partly attributed to gender differences in preferences for firm characteristics.

Practical/implications
– The findings suggest that the gender gap can be mitigated by giving more priority to the choices of female investors with respect to firm characteristics. In turn, this may reduce a part of the gender gap in investing. Moreover, the findings would assist companies to understand and know how their shareholder’s preferences vary with respect to gender and investor’s groups.

Originality/value
– This paper provides evidence concerning the gender gap in investor’s self-declared preferences for firm characteristics across retail, financial professionals and institutional investors in Malaysia, which complements previous studies that used equity holdings data and only two groups of investors.
More women on Indian boards: moving beyond mere regulations and tokenism
Authors: Pathak Atul Arun , Purkayastha Anish 
Published: February 2016

Purpose
– This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies.

Design/methodology/approach
– This briefing is prepared by independent writers who add their own impartial comments and place the articles in context.

Findings
– In patriarchal societies such as India, there is great reluctance to allow women to take up leadership roles. Although the benefits of gender diversity in board composition are understood by organizations, there is limited progress. The government, companies and women who are potential board members all need to coordinate and work together towards solving this issue in the long run.

Research limitations/implications
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Practical implications
– The paper provides strategic insights and practical thinking that have influenced some of the world’s leading organizations.

Social implications
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Originality/value
– The briefing saves busy executives and researchers hours of reading time by selecting only the very best, most pertinent information and presenting it in a condensed and easy-to-digest format.