bluuebunny/crossref_metadata_2025_split huggingface dataset:
Blended learning dalam pembelajaran matematika: A systematic literature network analysis
Authors: Amelia Defrianti Putri  , Juandi Dadang , Turmudi Turmudi 
Published: September 2024

As technology continued to advance, the educational landscape evolved, leading to the development of learning management systems, online platforms, and multimedia resources. Blended learning has since become a cornerstone in educational strategies. The purpose of this study is to describe the research trend data on Blended learning . The Systematic Literature Network Analysis (SLNA) method was employed for the investigation. This study's data is made up of non-time-limited research articles on Blended learning. The articles were retrieved from the Scopus database. The data was evaluated using a bibliometric and network analysis technique with programs R and VOSviewer. The findings indicate that the number of studies and research citations fluctuate. Keyword cluster analysis indicates that the predominant focus of research lies in Blended learning. Simultaneously, the terms 'personnel training' and 'academic performance' exhibit interconnections with inquiries into Blended learning . Subsequent scholarly investigations ought to broaden and elaborate upon facets of Blended learning conceptualization, assessment methodologies, pedagogical instruction, and organizational backing, to furnish a more exhaustive and all-encompassing research outlook.
Tree Damage Type Classification Based on Forest Health Monitoring Using Mobile-Based Convolutional Neural Network
Authors: Gandadipoera Faishal Hariz Makaarim , Andrian Rico , Safei Rahmat 
Published: September 2024

One of the fundamental parts of surveying forest health conditions with Forest Health Monitoring (FHM) is to visually assess the damage experienced by trees under certain conditions. This visual assessment can be facilitated using a Convolutional Neural Network (CNN) which involves building the MobileNetV2 model architecture. The model was trained using 1600 image data with 16 classes. The image data was pre-processed by resizing it to 224x224. The data was categorized into three categories: 80% was allocated for training, 10% for validation, and testing with 10% also. Training was done by changing the values from batches with a maximum of 100 epochs. The model was then incorporated into a mobile application using TensorFlow Lite and testing the application gave satisfactory results. The model results get the best accuracy rate of 98.75% and a loss of 0.0497. This research concludes that the classification of tree damage types based on FHM with CNN can be done. For accurate results, the image provided by the user must be clear and reflect the actual damage observed on the tree.
Calculated PRA and PIRCHE Algorithm in Kidney Transplant Recipients
Authors: Ivana Dedinska , Andrej Ceres , Martina Schniederova , Karol Granak , Matej Vnucak , Monika Beliancinova , Patricia Kleinova , Timea Blichova , Milos Jesenak 
Published: September 2024

Abstract

Introduction
Calculated PRA testing in kidney transplantation has revolutionized the field by enabling a more accurate assessment of compatibility and risk prediction for AMR. On the other hand, The PIRCHE algorithm aims to identify the potentially immunogenic human leukocyte antigens (HLA) epitopes on the donor graft that are recognized by the recipient's HLA antibodies.
The aim of this analysis was to compare the actual immunological risk at the time of transplantation with the hypothetical risk that would be determined by cPRA and PIRCHE. Another aim was to compare this hypothetical risk also in the context of the development of DSA and the protocol graft biopsy at month 3.

Material and methods
In a group of 20 patients we recorded the real immunological risk determined at the time of transplantation according to the induction immunosuppression protocol of the Transplant-Nephrology Department of the University Hospital Martin and compared it with the hypothetical calculated risk according to cPRA and PIRCHE. We then compared the hypothetical risk with the protocol biopsy result and with any evidence of donor-specific antibodies at month 3 after the kidney transplantation.

Results
Under cPRA, the two patients we assessed as medium risk in real time would be classified as low risk. Both of these patients did not have DSA identified at month 3 and did not have rejection changes in the protocol biopsy. According to PIRCHE, the immunological risk would change from moderate to low in two patients, and even from very high to low in one patient. In none of these patients did we subsequently observe DSA formation at month 3 post-transplantation, and also all three protocol biopsies were free of rejection changes in these patients.

Conclusion
In our analysis we confirmed the importance of both immunological and non-immunological parameters for determining risk at the time of transplantation. For using PIRCHE score larger studies are required to confirm this strategy.
Functions of Adipocytokines and Link with Primary Glomerulonephritis
Authors: Monika Beliancinova , Timea Blichova , Patricia Kleinova , Matej Vnucak , Karol Granak , Ivana Dedinska 
Published: September 2024

Abstract
Adipocytokines are substances with endocrine functions produced by adipose tissue, playing crucial roles in regulating metabolic functions and inflammatory processes. Dysregulation of fatty tissue's endocrine functions and dysregulation of the production of adipocytokines such as adiponectin, leptin, fibroblast-stimulating factor, and others can lead to a low-grade systemic inflammation and an insulin resistance in patients. These conditions contribute to the pathophysiology of type 2 diabetes mellitus, atherosclerosis, arterial hypertension, metabolic syndrome, and other disorders. Conversely, these metabolic disorders exert feedback-regulatory effects on adipocytokines and their functions.
Glomerulonephritis encompasses a group of immune-mediated diseases characterized by inflammation of the glomeruli. Diagnosis can involve examining urine sediment, detecting autoantibodies, and identifying immune complexes in the blood. However, a kidney biopsy is required for definitive confirmation of glomerulonephritis and is considered the gold standard and a necessity in diagnosis.
Affecting the level of adipocytokines could be one of the new strategies for the pharmacological treatment of many diseases. Given a better understanding of their functions and molecular targets, adipocytokines may herald the emergence of new diagnostic approaches (1, 2). Monitoring the level of adipocytokines could contribute to a better patient management and thus become an auxiliary tool for predicting and diagnosing diseases.
IgA Nephropathy – Current and Future Perspectives in Treatment
Authors: Karol Granak , Matej Vnucak , Monika Beliancinova , Patricia Kleinova , Timea Blichova , Margareta Pytliakova , Ivana Dedinska 
Published: September 2024

Abstract
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulopathy in our adult population and is associated with a high lifetime risk of kidney failure. Recent years have succeeded in describing the pathogenesis of IgAN at the molecular level, where immune complexes containing specific galactose deficient IgA1 play an essential role. The gold standard in the diagnosis of IgAN remains renal biopsy followed by determination of a prognostic score using the Oxford classification.
A fundamental goal in the management of patients with IgAN is to optimize supportive therapy involving active lifestyle modification and renoprotective medications. The reno-protective drug menu has recently been expanded to include effective sodium-glucose cotransporter 2 inhibitors (SGLT2i), and additional agents are on the way. However, despite maximal supportive therapy, a wide range of patients remain at high risk of disease progression and require the deployment of immunomodulatory drugs. To date, however, we do not have high potency agents that are well tolerated and safe. This has led to the initiation of many studies to target the inflammatory process at different pathogenetic levels.
In this article, we summarize the current standards in the treatment of IgAN and present new promising options in the management of this disease.
The Monoclonal Gammopathies of Renal Significance
Authors: Patricia Kleinova , Timea Blichova , Monika Beliancinova , Matej Vnucak , Karol Granak , Ivana Dedinska 
Published: September 2024

Abstract
As a heterogeneous group of diseases, monoclonal gammopathy is typical for older age and is characterized by the presence of paraprotein in serum and urine. In addition to damage to the bone marrow, other organs are also affected, whereas in the case of monoclonal gammopathy of renal significance (MGRS), the kidneys are dominant. The clinical presentation of MGRS is diverse depending on the type of renal monoclonal gammopathy. The basis of the diagnosis is the detection of free light chains in the serum, along with electrophoresis and subsequent serum immunofixation. The kappa and lambda serum light chain ratio is evaluated in patients with MGRS within modified reference parameters. A kidney biopsy provides information on the extent of renal parenchymal involvement. The basis of therapy is chemotherapeutics with possible autologous stem cell transplantation to preserve kidney function.
The Role of the Nephrologist in the Treatment and Prevention of Nephrolithiasis
Authors: Matej Vnucak , Karol Granak , Monika Beliancinova , Patricia Kleinova , Timea Blichova , Ivana Dedinska 
Published: September 2024

Abstract
Nephrolithiasis is a disease with a high risk of recurrence: 50% within five years and up to 80–90 % within 10 years after the first episode. Often, with this diagnosis, there is only symptomatic treatment with the aim of expelling the kidney stone and removing the pain. In such patients, however, initial stratification of the risk of recurrence based on the risk factors present is essential. Every patient with nephrolithiasis, whether it is a single episode or recurrent, should follow general measures to prevent kidney stones. Depending on the results of the kidney stone analysis and the risk of recurrence, it is necessary to carry out a specialised nephrological metabolic examination which is performed by a nephrologist in Slovakia, with subsequent personalised recommendations depending on the cause of recurrent nephrolithiasis. These include dietary and regimen measures, as well as pharmacological treatment.
In the following article we summarize specific measures for individual types of nephrolithiasis, as well as basic preventive measures for the recurrence of kidney stones, with a focus on dietary risk and protective factors.
Development of New Formulation of Inosine Acedoben Dimepranol Powder for Oral Solution in Sachets
Authors: Kafedjiiski K. , Belcheva V. , Radeva-Ilieva M. , Grigorov E. 
Published: September 2024

Abstract
Inosine Acedoben Dimepranol (IAD) has immunomodulatory and antiviral properties and is used in the treatment of viral infections. The aim of the present study was to develop a powder for oral solution in sachets containing high dose IAD (1000 mg). The formulations were prepared by direct dry mixing of the components using the dilution principle. Optimal composition and process parameters for the development of high dosage powder were established. Solubility studies showed pH-dependent solubility of IAD. The prepared powder was characterized by a short reconstitution time. In addition, the oral solution exhibits good organoleptic properties and remains stable for 30 min. Stability studies indicated that the sachets remained stable under accelerated conditions for 3 months. In conclusion, the developed powder for oral solution in sachets containing 1000 mg IAD represents an economical alternative to other solid dosage forms with the advantages of rapid dissolution and convenient intake for the patient.
Ectopic Pancreatic Tissue Presenting as Gastric Tumor – A Case Report
Authors: Chernopolsky P. , Bozhkov V. 
Published: September 2024

Abstract
Heterotopic pancreas is a pancreatic tissue located outside the usual anatomical location of the pancreas. Heterotopic pancreas was first described in 1727 by Schultz in the diverticulum of the ileum. A 61-year-old man was admitted to the Second Department of Surgery with the following complaints: heaviness and pain in the epigastrium and right subcostal area, accompanied by nausea, vomiting, lack of appetite and weight reduction about 20 kg over the last few months. Intraoperatively tumor formation was found located in the pyloro-antral gastric area with approximate size 4/5 cm in diameter. The histological examination of the specimen revealed an uncapsulated formation of pancreatic glandular serine acres and single Langerhans islets among cystic dilated and deformed pancreatic ducts without epithelial cellular atypia.
Sarcoidosis of the Orbit: A Rare Clinical Case and Literature Review
Authors: Cekov A. , Kanev A. 
Published: September 2024

Abstract
Sarcoidosis is a systemic disease of still-unknown etiology in which characteristic granulomas develop in various parts of the body. Symptoms depend on the localization of the formations. The isolated orbital form, in which granulomas develop only in the orbit of the eye, is very rare and presents a challenge in terms of differential diagnosis. Treatment for the orbital form may include a conservative, surgical, or combined approach. The goal of surgical treatment is to completely remove the tumour formation, which achieves excellent results in many cases. The current article presents a clinical case of an isolated orbital form of sarcoidosis, in which surgical treatment was undertaken with complete removal of the granulomatous formation. In the postoperative follow-up, a complete reversal of the symptoms was observed without residual disturbances in vision or eye movements.
Current Aspects in the Diagnosis and Management of Catheter-Related Sepsis, Observed in Patients Undergoing Hemodialysis with a Tunneled Catheter
Authors: Borisov B. , Borisov D. 
Published: September 2024

Abstract
Tunnelled catheters have become established as a common vascular access in the last few decades. Besides the convenience associated with their use, we also reap the bitter fruits of their complications. Catheter-associated infections are part of daily life in dialysis units and we must know them well – early diagnosis, adequate behaviour and prevention. The aim of this short review is to highlight some modern aspects of diagnosis and treatment of catheter-associated infections, while also sharing our modest experience.
Determinants of the expression of sexual behaviour in mammals
Authors: Kondracki Stanisław , Górski Krzysztof , Iwanina Maria , Wysokińska Anna , Pietruszka Arkadiusz , Gaczarzewicz Dariusz , Stasiak Karolina 
Published: September 2024

Abstract
The article contains a literature review of facts and views on the strategies of sexual behaviour in mammals, taking into account the role of the animal’s species, sex, and position in the herd. The role of the senses, brain, and hormones in the expression of animals’ sexual behaviour is discussed, as well as the role of induction of the coitus reflex and social behaviour in the reproduction of present-day wild and domesticated animals. The analysis shows that the predominant strategy of sexual behaviour in females is to attract multiple potential partners to acquire the best male. The predominant strategies in the sexual behaviour of males of most mammalian species are aimed at fertilizing as many females as possible. Expression of sexual behaviour requires the generation of a set of characteristic sexual reflexes that indicate readiness to copulate and are sexually stimulating. Animals are differ in expressing their sexual behaviour. Some individuals react quickly and dynamically to sexual stimuli and immediately begin coitus, while others require longer preparation for successful coitus. Sexual behaviour influences the status of individuals in some species. Wild mammals with high expression of the sexual behaviour typical of a given species usually occupy a dominant position, which gives them an advantage in the search for breeding partners, access to food, and the expression of preferred social behaviour. Expression of sexual behaviour is stimulated by stimuli from potential sexual partners, which induce copulatory reflexes. These reflexes have been described in numerous animal species. They should be generated in the proper order and proceed without disruption for successful coitus and fertilization to occur.
Enhancing the feed efficiency of crop residues in ruminants: a comprehensive review
Authors: Kamal Mahmoud , Aldhalmi Ahmed K. , Abd El-Hack Mohamed E. , Elsherbeni Ahmed I. , Youssef Islam. M. , Hussein Saddam , Bai Binqiang , Xu Zhenhua , Hao Lizhuang , Mahrose Khalid M. , Taha Ayman , Cheng Yanfen 
Published: September 2024

Abstract
Worldwide, the production of agricultural residues exceeds five billion metric tons per year. Regardless of their many applications and substantial potential to increase crop and animal productivity, many crop residues, particularly in Asian, African, and Arabian nations, are burned. This detrimental practice limits the recycling of soil nutrients while increasing air pollution and wellness risks. Enhancing feed efficiency while simultaneously lowering production costs and increasing animal protein is a key objective of nutritional supplements in livestock feeding. Antibiotics have been utilized in farm animals at sub-therapeutic levels to increase feed use effectiveness and digestion, as well as animal welfare and performance. However, the present ban on antibiotics as nutritional supplements has boosted the search for substitutes, with natural feed additives considered cutting-edge options. On the other hand, feed that has undergone biological treatment improves animal productivity, feed intake, and digestibility. Nevertheless, the absence of agents and expertise and substrate weight decrease may result in a 40% dry matter loss limits application. In this review, we look at the importance of detrimental residue administration and the advancement and adoption of technologies to handle surplus residue.
Aquaculture and climate change: a data-driven analysis
Authors: Moss Amina , Peh Jia Hui , Afiqah-Aleng Nor , Segaran Thirukanthan Chandra , Gao Huan , Wang Panpan , Handayani Kiki Syaputri , Lananan Fathurrahman , Wei Lee Seong , Fitzer Susan , Azra Mohamad Nor 
Published: September 2024

Abstract
As climate change increasingly impacts the aquaculture industry, it poses challenges to production quality, management, and sustainability. This study provides a scientometric analysis of 47 years of research on aquaculture and climate change, analysing 4,785 articles and 224,895 references through CiteSpace software. The study highlights enduring themes such as “ocean acidification” and “global warming,” alongside emerging concerns like “deforestation” and “nutrient runoff,” reflecting new research directions. Notably, “seasonal variations” persist as a key focus due to their significant impact on aquaculture practices. Fourteen research clusters were identified, revealing a diverse array of topics from environmental performance to the effects of blue food systems and ocean acidification on marine life. Clusters related to “carbon sequestration,” “seaweed farming,” and “integrated multi-trophic aquaculture (IMTA)” emphasise the shift toward innovative practices aimed at mitigating climate impacts and enhancing sustainability. The analysis shows a need for more collaborative research, particularly from leading contributors such as the USA, Europe and Australia with underrepresented regions like Southeast Asia and Africa, to develop resilient aquaculture systems capable of adapting to climatic challenges. It advocates for the integration of new technologies and the exploration of sustainable aquaculture practices that minimise environmental impacts while enhancing global food security. This approach sets a direction for future research to promote adaptive strategies and technological innovations in aquaculture.
Streptomyces kunmingensis XK9 and galactooligosaccharide synergistically enhance growth performance, nonspecific immunity and disease resistance in striped catfish (Pangasianodon hypophthalmus)
Authors: Hien Nguyen Thi Thu , Huyen Vu Thi Bich , Trung Nguyen Thi , Phong Truong Quoc , Phuoc Man Hong , Hoa Bui Thi Hai , Hang Trinh Thi Thu , Le Dinh Thi Thu , Ha Le Thanh Hai , Hai Le Minh , Binh Ta Thi , Tam Pham Thi 
Published: September 2024

Abstract
The present study evaluated the effectiveness of the synergy of Streptomyces kunmingensis XK9 and galactooligosaccharides (GOS) in improving growth performance, nonspecific immunity, and protection of striped catfish (Pangasianodon hypophthalmus). Seven feed regimens were tested in striped catfish fingerlings, including commercial pellets supplemented with preparations S7, S8, and S9 containing XK9 at 107 CFU/mL, 108 CFU/mL, and 109 CFU/mL, respectively; G5 containing 5% GOS; S7G5, S8G5, and S9G5 including 5% GOS and XK9 at different doses of 107 CFU/mL, 108 CFU/mL, and 109 CFU/mL, respectively. After 3 months of treatment with different dietary regimens, weight gain, specific growth rate, weight gain rate, and feed conversion ratio were greatly improved in fish-fed diets containing S9, S8G5, and S9G5 (p<0.05). Nonspecific immune parameters, including total white blood cell, phagocytic activity, and phagocytic index, increased consistently in fish that were fed diets containing synbiotics S8G5 and S9G5 (p<0.05). Lysozyme and complement activity increased substantially in fish that were fed diets supplemented with S9G5 (p<0.05). The protective effect of XK9 and GOS on striped catfish was evaluated after 15 days of challenge with Edwardsiella ictaluri. The results achieved show that the cumulative mortality rate sharply decreased in fish fed a diet containing the synbiotic S9G5, down 2.17 times compared to the control group; pathogen density was lowest in tanks of fish that were fed regimens containing S8G5, S9G5, and S9 (p<0.05). The results suggest that synbiotics, including S. kunmingensis XK9 and GOS, have the potential to be applied in sustainable farming for the striped catfish industry.
Antibiotic alternatives to produce organic poultry meat as a safe food source and the impact of its consumption on human health: A review
Authors: Abd El-Hack Mohamed E. , Aldhalmi Ahmed K. , Abu-Hiamed Hind A. , Almarkhan Wafa D. , Alharbi Nouf A. , Alhassani Walaa E. , Alkholy Sarah O. , Kamal Mahmoud , Youssef Islam M. , Khalifa Norhan E. , Taha Ayman E. , Swelum Ayman A. 
Published: September 2024

Abstract
The scientific evidence on the effects of consuming organic chicken meat on human health is examined in this review article. Few studies particularly look at the effects of eating organic chicken meat on people’s health. Although the evidence is conflicting, they speculate that consuming organic chicken meat may reduce the incidence of obesity and allergy-related illnesses. Customers who purchase organic chicken meat generally have healthier eating habits. The significance of these discoveries for human health is unclear. Still, animal and poultry studies suggest that whether agriculture produces food from conventional or organic sources has different effects on early development and physiology. Omega-3 fatty acids and meat are more abundant in organic than in common meat. However, this is not nutritionally relevant compared to other dietary sources. The widespread use of pharmaceuticals is one of the primary drivers of antimicrobial resistance in traditional animal agriculture. It is possible to reduce this risk and potentially have significant positive effects on public health by preventing animal sickness and using antibiotics more sparingly, as is done in organic farming. The review highlights the importance of organic feeds as an effective and vital alternative to antibiotics in the poultry industry and their impact on human health.