bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child play and caregiver support to promote convalescence following severe acute malnutrition in Zimbabwe: The Tamba‐SAM pilot study
Authors: Kabongo Jacqueline , Mudawarima Louisa , Majo Florence D. , Dzikiti Anesu , Tome Joice , Chasekwa Bernard , Mutasa Batsirai , Dzapasi Lloyd , Munetsi Epiphania , Cordani Isabella , Ntozini Robert , Langhaug Lisa F. , Bwakura‐Dangarembizi Mutsa , Prendergast Andrew J. 
Published: September 2024

AbstractChildren hospitalised for severe acute malnutrition (SAM) have a high risk of mortality, relapse and rehospitalisation following hospital discharge. Current approaches fail to promote convalescence, or to address the underlying social determinants of SAM, meaning that restoration of long‐term health, growth and neurodevelopment is not achieved. Although guidelines recommend play and stimulation to promote recovery, most caregivers are not supported to do this at home. We set out to evaluate the feasibility and acceptability of a codesigned intervention package aimed at providing child stimulation through play, and strengthening caregiver capabilities through problem‐solving skills, peer support and income‐generating activities. We evaluated the intervention in two phases, enroling 30 caregiver–child pairs from paediatric wards in Harare, Zimbabwe, once children who had been hospitalised with SAM were ready for discharge. Children were median 17.8 months old, and 28.6% had human immunodeficiency virus. Trained intervention facilitators (IFs)—lay workers whose own children had previously had SAM—delivered the intervention over 12 weeks with nurse supervision. Qualitative interviews with caregivers and IFs showed that the intervention was feasible and acceptable. Participants reported benefiting from the psychosocial support and counselling, and several started income‐generating projects. Caregivers appreciated the concept of play and caregiver–child interaction, and all reported practising what they had learned. By Week 12, caregiver mental health and caregiver–child interaction improved significantly. Overall, the intervention was feasible, acceptable and showed promise in modifying caregiver knowledge, attitudes and practice. An efficacy trial is now needed to evaluate whether the intervention can improve child convalescence following complicated SAM.
Sexually selected differences in warbler plumage are related to a putative inversion on the Z chromosome
Authors: Dunn Peter O. , Sly Nicholas D. , Freeman‐Gallant Corey R. , Henschen Amberleigh E. , Bossu Christen M. , Ruegg Kristen C. , Minias Piotr , Whittingham Linda A. 
Published: September 2024

AbstractLarge structural variants in the genome, such as inversions, may play an important role in producing population structure and local adaptation to the environment through suppression of recombination. However, relatively few studies have linked inversions to phenotypic traits that are sexually selected and may play a role in reproductive isolation. Here, we found that geographic differences in the sexually selected plumage of a warbler, the common yellowthroat (Geothlypis trichas), are largely due to differences in the Z (sex) chromosome (males are ZZ), which contains at least one putative inversion spanning 40% (31/77 Mb) of its length. The inversions on the Z chromosome vary dramatically east and west of the Appalachian Mountains, which provides evidence of cryptic population structure within the range of the most widespread eastern subspecies (G. t. trichas). In an eastern (New York) and western (Wisconsin) population of this subspecies, female prefer different male ornaments; larger black facial masks are preferred in Wisconsin and larger yellow breasts are preferred in New York. The putative inversion also contains genes related to vision, which could influence mating preferences. Thus, structural variants on the Z chromosome are associated with geographic differences in male ornaments and female choice, which may provide a mechanism for maintaining different patterns of sexual selection in spite of gene flow between populations of the same subspecies.
Chitosan stimulates root hair callose deposition, endomembrane dynamics, and inhibits root hair growth
Authors: Drs Matěj , Krupař Pavel , Škrabálková Eliška , Haluška Samuel , Müller Karel , Potocká Andrea , Brejšková Lucie , Serrano Natalia , Voxeur Aline , Vernhettes Samantha , Ortmannová Jitka , Caldarescu George , Fendrych Matyáš , Potocký Martin , Žárský Viktor , Pečenková Tamara 
Published: September 2024

AbstractAlthough angiosperm plants generally react to immunity elicitors like chitin or chitosan by the cell wall callose deposition, this response in particular cell types, especially upon chitosan treatment, is not fully understood. Here we show that the growing root hairs (RHs) of Arabidopsis can respond to a mild (0.001%) chitosan treatment by the callose deposition and by a deceleration of the RH growth. We demonstrate that the glucan synthase‐like 5/PMR4 is vital for chitosan‐induced callose deposition but not for RH growth inhibition. Upon the higher chitosan concentration (0.01%) treatment, RHs do not deposit callose, while growth inhibition is prominent. To understand the molecular and cellular mechanisms underpinning the responses to two chitosan treatments, we analysed early Ca2+ and defence‐related signalling, gene expression, cell wall and RH cellular endomembrane modifications. Chitosan‐induced callose deposition is also present in the several other plant species, including functionally analogous and evolutionarily only distantly related RH‐like structures such as rhizoids of bryophytes. Our results point to the RH callose deposition as a conserved strategy of soil‐anchoring plant cells to cope with mild biotic stress. However, high chitosan concentration prominently disturbs RH intracellular dynamics, tip‐localised endomembrane compartments, growth and viability, precluding callose deposition.
Pepper RING‐Type E3 Ligase CaFIRF1 Negatively Regulates the Protein Stability of Pepper Stress‐Associated Protein, CaSAP14, in the Dehydration Stress Response
Authors: Bae Yeongil , Lim Chae Woo , Lee Sung Chul 
Published: September 2024

ABSTRACTAs part of the cellular stress response in plants, the ubiquitin–proteasome system (UPS) plays a crucial role in regulating the protein stability of stress‐related transcription factors. Previous study has indicated that CaSAP14 is functionally involved in enhancing pepper plant tolerance to dehydration stress by modulating the expression of downstream genes. However, the comprehensive regulatory mechanism underlying CaSAP14 remains incompletely understood. Here, we identified a RING‐type E3 ligase, CaFIRF1, which interacts with and ubiquitinates CaSAP14. Pepper plants with silenced CaFIRF1 exhibited a dehydration‐tolerant phenotype when subjected to dehydration stress, while overexpression of CaFIRF1 in pepper and Arabidopsis resulted in reduced dehydration tolerance. Co‐silencing of CaFIRF1 and CaSAP14 in pepper increased sensitivity to dehydration, suggesting that CaFIRF1 acts upstream of CaSAP14. A cell‐free degradation analysis demonstrated that silencing of CaFIRF1 led to decreased CaSAP14 protein degradation, implicating CaFIRF1 in the regulation of CaSAP14 protein via the 26S proteasomal degradation pathway. Our findings suggest a mechanism by which CaFIRF1 mediates the ubiquitin‐dependent proteasomal degradation of CaSAP14, thereby influencing the response of pepper plants to dehydration stress.
Stress‐Induced Autophagy Is Essential for Microspore Cell Fate Transition to the Initial Cell of Androgenesis
Authors: Luo Pan , Zhao Zifu , Yang Fan , Zhang Lai , Li Siyuan , Qiao Ying , Zhang Liangxinyi , Yang Mingchun , Zhou Xiaotong , Zhao Linlin , Yang Yong , Tang Xingchun , Shi Ce 
Published: September 2024

ABSTRACTThe isolated microspores can be reprogrammed towards embryogenesis via stress treatment during in vitro culture, and produce (doubled) haploid plants as a breeding source of new genetic variability. However, the mechanism underlying the cell fate transition from gametogenesis to embryogenesis remains largely unknown. Here, we report that autophagy plays a key role in cell fate transition for microspore embryogenesis (referred to as androgenesis) in Nicotiana tabacum. Immunofluorescence and transmission electronic microscopy detection unveiled that autophagy was triggered in microspores following exposure to inductive stress, and a transient wave of the numerous autophagy‐related genes (ATGs) expression occurred before the initiation of microspore embryogenesis. Suppression or promotion of the original autophagy levels could inhibit microspore embryogenesis, indicating that stress‐induced autophagic homeostasis is essential for cell fate transition. Furthermore, quantitative proteomics analysis revealed that autophagy might be involved in lignin biosynthesis and chromatin decondensation for promoting reprogramming for androgenesis initiation. Altogether, we reveal an essential role of autophagy in the microspore cell fate transition and androgenesis initiation, providing novel insight for understanding this critical developmental process.
I can feel my heartbeat: The relationship between interoceptive abilities and emotional states during stress and recovery in healthy adolescents
Authors: Braet Jolien , Braet Caroline 
Published: September 2024

AbstractThe goal of the current study was to investigate the differential effects of three interoception dimensions on psychophysiological stress responses (reactivity and recovery) in adolescents. A total of 102 adolescents (Mage = 14.10 years, SDage = 0.63; 50 males) completed the heartbeat counting task with adapted instructions to assess interoceptive accuracy, sensibility, and awareness. During a follow‐up session, participants underwent a standardized stressful task, throughout which measures of negative affect and respiratory sinus arrythmia (RSA) were collected. Results from multilevel models indicated that adolescents with higher interoceptive accuracy reported less pronounced increases in negative affect during stress induction, and subsequently experienced a less steep decrease in negative affect during recovery, compared to those with lower accuracy. Regarding RSA, adolescents with higher interoceptive accuracy exhibited greater decreases in RSA from baseline to stress, while those with higher interoceptive awareness maintained higher RSA levels throughout the experiment. In contrast, individuals with higher interoceptive sensibility exhibited lower levels of RSA during the experiment. These findings add to the limited literature on interoception in adolescents by illuminating its role in emotional experiences, stress responses, and recovery processes. Our study suggests that examining distinct dimensions of interoception, along with physiological measures during stress and recovery, is crucial for understanding its beneficial or adverse effects in adolescence. The complexity and potential significance of interoceptive dimensions extend beyond their correlations with traditional self‐report measures, warranting further investigation to clarify their implications and underlying mechanisms.
Erythropoiesis in Teleost Fishes: The Fantastic Biological Process
Authors: Zhong Aihua , Yan Xiaojun 
Published: September 2024

ABSTRACTGlobal fish production exceeds 170 million tons in 2023, and provides a high‐quality protein source for humans. However, various factors may contribute to hypoxic stress and anemia, which contribute to yield loss in fish production. Elevated red blood cell counts or activation of erythropoiesis are well‐known responses to anemia and hypoxia stress in fish. Erythropoiesis is the process of formation of new erythrocytes, from hemopoietic stem cells, through the differentiation of erythroblasts, to the maturation of red blood cells. This step‐wise process is governed by complex transcriptional, post‐translational, and epigenetic programs in response to extracellular signals. This review summarizes developing knowledge regarding erythropoiesis in teleosts, including the wave and site of erythropoiesis, specification of the erythroid lineage, and molecular regulation mechanisms. A summary of research gaps is presented, to be addressed by future research on teleosts. Understanding erythropoiesis facilitates improved fish husbandry and selective breeding of hypoxia‐tolerance fish, to ultimately contribute to increased production.
A Comprehensive Review of Diatom‐Bacterial Interactions Inferred From Bibliometric Analysis
Authors: Hu Caiqin , Shi Zhen , Hu Tiehuan , Gao Yuan , Liu Qianfu , Wang Chao 
Published: September 2024

ABSTRACTDiatoms and bacteria have coexisted and coevolved for more than 200 million years, and their interactions have driven the processes of underlying major biogeochemical cycles. These complex and heterogeneous interactions span the range from synergistic to competitive and antagonistic, and they are regulated by diverse metabolites and biochemical mediators. Despite the significance of diatom–bacterial interactions in shaping aquatic food webs, driving nutrient cycles, and controlling algal blooms, the field currently lacks a comprehensive review of the current literature, research contents, and future research trends and perspectives. This review presents a comprehensive analysis of diatom–bacterial interactions by summarizing the information from current publications, including temporal trends, the most productive authors, journals, and countries, and illustrating current research contents, including regions, methods, foci, the interaction mechanisms and the environmental regulation. In addition, we discuss future research trends and perspectives. Our results indicate that most of the current research has been conducted in the ocean, using the methods of co‐culture experiments or field investigation combined with high‐throughput sequencing. The current research foci include the mechanisms of multiple cell‐to‐cell synergistic, competitive, antagonistic interactions, and multiple interactions regulated by biochemical molecules, and potential biotechnological applications. Furthermore, the future trends in this research field concern the underlying mechanisms of variation in diatom–bacterial interactions influenced by environmental changes and the possible applications. This review provides a comprehensive perspective on diatom‐bacterial relationships as well as a guide to future research.
Quantitative risk assessment of radiocesium associated with Japanese foods imported into the United Kingdom
Authors: Adkin Amie , Rylands Kay , Goodman Jessica , Oatway Wayne , Uy Frederique M. , Edge Joanne , Potter Claire 
Published: September 2024

AbstractDamage to a nuclear power station resulted in radioactive contamination of certain areas of Japan in 2011. Legislation was put in place in Europe to establish controls on the import of certain types of food and feed, including a limit of 100 radioactive decays (becquerel, Bq) per second of radiocesium per kg. This legislation was retained in the United Kingdom after leaving the EU and then reviewed in 2021. A quantitative risk assessment was developed to estimate the radiological risk to public health from consuming Japanese food imported into the United Kingdom should the maximum level on radiocesium be removed. Although Japanese monitoring data indicated occurrences when products exceeded the 100 Bq per kg limit, these were found to be rare; a total of 1485 occurrences (0.0013%) of all measured foodstuff samples (>1 million) within the scope of this assessment had radiocesium activity concentrations that exceeded 100 Bq per kg. Using the recorded occurrence and level of radiocesium measured, and the current pattern and volume of food imported from Japan, there was an estimated excess risk of fatal cancer of around one in a million per year, categorized as negligible compared to the baseline 2018–2020 UK cancer fatality rate of around 1 in 4. On the basis of the described assessment and the estimated small additional risk, Great Britain lifted import controls related to radioactivity present in food from Japan. A number of recommendations to address data gaps and approaches in this assessment are made, particularly how we can improve modeling UK dietary habits for specialist foods.
Health expenditure, and economic growth in Sub‐Saharan African countries: The role of governance quality
Authors: Ikpe Marius , Madueme Stella I. , Ojike Richard Okey , Agbanike Tobechi F. , Anochiwa Lasbrey I. , Odionye Joseph Chukwudi 
Published: September 2024

AbstractThis study assessed the moderating influence of governance quality on the effect of health expenditure on economic growth, and exploring the analysis further to determine whether there exists possible heterogeneity in the distribution of this effect amongst 27 Sub‐Saharan African countries for the period 2005–2021. Public health expenditure (HExp), and six indicators of governance quality (control of corruption [Ccor], rule of law [Rlaw], political stability [Post], voice and accountability [Vacc], government effectiveness [Geft], and regulatory quality [Regq]) were utilised as proxy(ies) for HExp, and governance respectively. Two‐step dynamic panel data system generalised method of moments (DPD‐SGMM) estimation technique was used to estimate the conditional mean effect, while Possible heterogeneity in the distribution was explored using the method of moments quantile regression (MM‐QR); the study relied on annual time‐series indices of governance as developed by Kaufman and Kraay. Estimates demonstrate that: (i) while a significant positive relationship was observed between HExp and economic growth, Rlaw, Vacc, and Regq significantly reduce economic growth, (ii) interaction between HExp, and Vacc, Regq, individually increases the potency of HExp to stimulate economic growth by 2.2%, and 1.2% respectively, as against 1.3% reduction for Rlaw, (iii) no heterogeneity was observed in the distribution of these amongst the sample of countries.
Patho‐immunological mechanisms of atopic dermatitis: The role of the three major human microbiomes
Authors: Zhou Zhaosen , Yang Jing , Liu Qin , Gao Jing , Ji Wenting 
Published: September 2024

AbstractAtopic dermatitis (AD) is a genetically predisposed allergic inflammatory dermatosis with chronic, pruritic, and recurrent features. Patients with AD have dry and itchy skin, often accompanied by chronic eczematous lesions, allergic rhinitis, or asthma, which has a considerable impact on their daily lives. With advances in genome sequencing technology, it has been demonstrated that microorganisms are involved in this disease, and the microorganisms associated with AD are attracting considerable research attention. An increasing number of studies conducted in recent years have demonstrated that an imbalanced microbiome in AD patients has substantial impact on disease prognosis, and the causes are closely tied to various immune mechanisms. However, the involvement of microorganisms in the pathogenesis of AD remains poorly understood. In this paper, we review the advances in research on the immunological mechanisms of the skin microbiome, intestinal microbiome, and lung microbiome that are related to AD prognosis and immunotherapy protocols. It is hoped that this approach will lay the foundation for exploring the pathogenesis of and emerging treatments for AD.
Tobit models for count time series
Authors: Weiß Christian H. , Zhu Fukang 
Published: September 2024

AbstractSeveral models for count time series have been developed during the last decades, often inspired by traditional autoregressive moving average (ARMA) models for real‐valued time series, including integer‐valued ARMA (INARMA) and integer‐valued generalized autoregressive conditional heteroscedasticity (INGARCH) models. Both INARMA and INGARCH models exhibit an ARMA‐like autocorrelation function (ACF). To achieve negative ACF values within the class of INGARCH models, log and softplus link functions are suggested in the literature, where the softplus approach leads to conditional linearity in good approximation. However, the softplus approach is limited to the INGARCH family for unbounded counts, that is, it can neither be used for bounded counts, nor for count processes from the INARMA family. In this paper, we present an alternative solution, named the Tobit approach, for achieving approximate linearity together with negative ACF values, which is more generally applicable than the softplus approach. A Skellam–Tobit INGARCH model for unbounded counts is studied in detail, including stationarity, approximate computation of moments, maximum likelihood and censored least absolute deviations estimation for unknown parameters and corresponding simulations. Extensions of the Tobit approach to other situations are also discussed, including underlying discrete distributions, INAR models, and bounded counts. Three real‐data examples are considered to illustrate the usefulness of the new approach.
Caring Technologies: Confronting Invisible Work in Digital Capitalism
Authors: Sciannamblo Mariacristina 
Published: September 2024

ABSTRACTIn recent years, critical studies on digital platforms have emphasized that contemporary capitalism increasingly exploits the relational and cognitive faculties of human beings as sources of value. At the same time, activist projects are emerging in order to challenge the logics of commodification, individualization and accumulation that govern digital capitalism, being grounded in values that aim to promote visibility of labor and cooperation. This article contributes the notion of “caring technologies” where care is employed as a critical lens able to uncover the kinds of productive work made invisible by capitalist logics governing mainstream digital platforms and as a value for designing digital technologies aiming at challenging these very logics. By drawing on feminist theories about domestic work, we stress the analytical and interventionist character of care insofar as it sheds light on the forms of invisible work that allows the productive system to function and a politics that values social and economic relations usually neglected in the capitalist system. Ultimately, the article elaborates on a politics of caring to confront digital capitalism, transforming care into a logic that informs activist interventions which value agential and inalienable aspects characterizing the diverse forms of labor mediated by digital technologies.
Re‐imagining professional learning communities in education: Placing teacher leadership in STEM context
Authors: Martinovic Dragana , Milner‐Bolotin Marina 
Published: September 2024

AbstractThis conceptual analysis paper discusses the characteristics of teacher leadership (TL) in Science, Technology, Engineering, and Mathematics (STEM) education, presenting benefits for its development within the professional learning communities (PLCs). We describe our STEM education approach and argue that TL in STEM is different and more complex than leadership in any particular discipline. We compare two pathways for STEM learning and professional development (PD): engineering design approach and modeling approach. Then, we answer two research questions pertaining to the characteristics of STEM teacher leaders' (TLRs) knowledge, dispositions, and skill set; the support TLRs need to empower STEM educators; and consequently, we discuss how PLCs can become vehicles for growing STEM TLRs and empowering teachers. When promoting integrated STEM, educators likely find themselves in an out‐of‐field teaching situation, where communication with their PLC's leaders and peers is crucial in developing epistemological multiliteracy and confidence. We elaborate on the four main characteristics of STEM PLCs: (1) collaborative nature; (2) focus on boosting teachers' pedagogical content knowledge and confidence; (3) evidence‐based decision making; and (4) advocacy for high‐quality STEM education, teacher education, and PD. Each feature serves different but complementary goals, suitable for developing and utilizing the seven dimensions of TL discussed in the literature.