bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-amplification and Characterization of Polymorphic Microsatellite Markers From Acacia (Senegalia) mellifera and Acacia brevispica to Acacia senegal (L.) Willd.
Authors: Omondi Stephen F. , Dangasuk O. G. , Odee D. W. , Cavers S. , Khasa D. P. 
Published: October 2017

Abstract
Seven polymorphic microsatellite markers isolated from Acacia brevispica and Acacia mellifera were successfully cross-amplified in Acacia senegal. The loci were surveyed for polymorphism using 30 samples. Allelic diversity ranged from 4 (Ame02, Ab06 and Ab18) to 13 (Ab26) per locus. The expected heterozygosity (HE) ranged from 0.543 (Ame02) to 0.868 (Ab26) while observed heterozygosity (HO) ranged from 0.516 (Ame05) to 0.800 (Ame03). Cross-amplification of these loci represents a potential source of co-dominant markers and will be useful in the study of genetic diversity, structure, gene flow and breeding systems of this important Acacia species.
Generalized Pustular Psoriasis in Association with Squamous Cell Carcinoma of the Hypopharynx
Authors: Milicic Vesna , Ravic-Nikolic Ana , Jovovic-Dagovic Bojana , Stojanovic Stevan , Mitrovic Slobodanka Lj. 
Published: October 2017

Abstract
Pustular psoriasis is an uncommon form of psoriasis consisting of widespread pustules on an erythematous background. Very rarely pustular psoriasis represent a paraneoplastic dermatosis. In this report we describe a case of generalized pustular psoriasis (GPP) associated with advanced, inoperable, metastatic squamous cell carcinoma of the hypopharynx. We suggest that physicians should be alert for the worsening of existing psoriasis or formation of novel psoriasiform eruptions and should undertake clinical evaluation of possible neoplastic disease.
Bacterial Flora Play Important Roles in Acute Dextran Sulphate Sodium-Induced Colitis But Are Not Involved in Gal-3 Dependent Modulation of Colon Inflammation
Authors: Markovic Bojana Simovic , Milosavljevic Neda , Arsenijevic Aleksandar , Gazdic Marina , Lukic Miodrag L. , Volarevic Vladislav 
Published: October 2017

Abstract
An altered immune response to normal gut microflora is important for the pathogenesis of ulcerative colitis (UC). Galectin- 3 (Gal-3) is an endogenous lectin that plays an important pro-inflammatory role in the induction phase of acute colitis by promoting activation of the NLRP3 infl ammasome and production of IL-1β in macrophages. By using dextran sulphate sodium (DSS) induced colitis, a well-established animal model of UC, we determined whether Gal-3 affects the function of colon infiltrating macrophages by interfering with intestinal microfl ora. Our results showed that genetic deletion of Gal-3 significantly attenuates DSS-induced colitis by down-regulating infiltration of phagocytic cells (neutrophils, macrophages and dendritic cells) in colon tissue of DSS-treated mice, and this correlated with differences in bacterial flora of the gut. Antibiotic treatment attenuates DSS-induced colitis in WT and Gal-3-/- mice without affecting differences between the groups. In conclusion, Gram negative bacterial flora play an important role in DSS-induced acute colitis of mice but are not involved in Gal-3 dependent modulation of colon inflammation.
Structured Matrix Methods Computing the Greatest Common Divisor of Polynomials
Authors: Christou Dimitrios , Mitrouli Marilena , Triantafyllou Dimitrios 
Published: October 2017

Abstract
This paper revisits the Bézout, Sylvester, and power-basis matrix representations of the greatest common divisor (GCD) of sets of several polynomials. Furthermore, the present work introduces the application of the QR decomposition with column pivoting to a Bézout matrix achieving the computation of the degree and the coeffcients of the GCD through the range of the Bézout matrix. A comparison in terms of computational complexity and numerical effciency of the Bézout-QR, Sylvester-QR, and subspace-SVD methods for the computation of theGCDof sets of several polynomials with real coeffcients is provided.Useful remarks about the performance of the methods based on computational simulations of sets of several polynomials are also presented.
Integrated Approach to Correcting the High-Bar Back Squat From “Excessive Forward Leaning”
Authors: Bishop Chris , Turner Anthony 
Published: October 2017

ABSTRACT
THE HIGH-BAR BACK SQUAT IS OFTEN CONSIDERED A CORNERSTONE IN AN ATHLETE'S PHYSICAL TRAINING PROGRAM BECAUSE OF ITS CAPACITY TO ENHANCE LOWER-BODY STRENGTH DEVELOPMENT. HOWEVER, MOVEMENT COMPENSATIONS ARE COMMON WITH MANY EXHIBITING AN “EXCESSIVE FORWARD LEAN” DURING THEIR TECHNIQUE. THIS ARTICLE AIMS TO OUTLINE THE POTENTIAL REASONS FOR THIS COMPENSATION. FURTHERMORE, POSSIBLE SOLUTIONS THAT COACHES COULD CONSIDER TO ADDRESS EXCESSIVE FORWARD LEAN AND OPTIMIZE HIGH-BAR BACK SQUAT TECHNIQUE HAVE BEEN OFFERED.
Molecular Basis of Overdominance at a Flower Color Locus
Authors: LaFountain Amy M , Chen Wenjie , Sun Wei , Chen Shilin , Frank Harry A , Ding Baoqing , Yuan Yao-Wu 
Published: October 2017

AbstractSingle-gene overdominance is one of the major mechanisms proposed to explain heterosis (i.e., hybrid vigor), the phenomenon that hybrid offspring between two inbred lines or varieties show superior phenotypes to both parents. Although sporadic examples of single-gene overdominance have been reported over the decades, the molecular nature of this phenomenon remains poorly understood and it is unclear whether any generalizable principle underlies the various cases. Through bulk segregant analysis, chemical profiling, and transgenic experiments, we show that loss-of-function alleles of the FLAVONE SYNTHASE (FNS) gene cause overdominance in anthocyanin-based flower color intensity in the monkeyflower species Mimulus lewisii. FNS negatively affects flower color intensity by competing with the anthocyanin biosynthetic enzymes for the same substrates, yet positively affects flower color intensity by producing flavones, the colorless copigments required for anthocyanin stabilization, leading to enhanced pigmentation in the heterozyote (FNS/fns) relative to both homozygotes (FNS/FNS and fns/fns). We suggest that this type of antagonistic pleiotropy (i.e., alleles with opposing effects on different components of the phenotypic output) might be a general principle underlying single-gene overdominance.
One-Year Language Outcomes in Toddlers With Language Delays: An RCT Follow-up
Authors: Hampton Lauren H. , Kaiser Ann P. , Roberts Megan Y. 
Published: October 2017

OBJECTIVES:
The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention.

METHODS:
Toddlers with language delays were recruited from the community, and 97 toddlers and parents were randomly assigned to receive usual community treatments or a 3-month EMT intervention with parent training. Multiple regression analyses were used to estimate the differences between groups at the 6- and 12-month follow-up periods. A subgroup of participants with receptive and expressive language delays was used in a post hoc moderator analysis of treatment outcomes.

RESULTS:
Children in the treatment arm did not differ from children in the control arm at 6- and 12-month follow-ups. However, post hoc analyses revealed that children with receptive-expressive language delays were persistently delayed relative to normative performance throughout the follow-up period.

CONCLUSIONS:
The immediate effects of the brief delivery of EMT were not sustained over the 1-year follow-up period. However, the short-term intervention may not have been sufficient for children with receptive-expressive delays to develop typical language abilities, suggesting they may need more intensive early intervention. Although this intervention may not be necessary for all children with primary language delays, future research should determine the extent to which children with receptive-expressive delays may benefit from more intensive intervention.
Emerging Microreaction Systems Based on 3D Printing Techniques and Separation Technologies
Authors: Ko Dong-Hyeon , Gyak Ki-Won , Kim Dong-Pyo 
Published: October 2017

Abstract
The past three decades have seen increasing progress in the integration and process diversification of microfluidic systems for use in chemistry, biochemistry, and analysis. Here we summarize recent achievements in microreaction modules and microseparation units. We look into recent developments of microreaction systems fabricated by various 3D printing techniques for chemical synthetic applications. Moreover, we take a look at the recent achievements of newly developed microseparation technologies with enhanced separation efficiency realized by adopting single or hybrid principles as well as novel device concepts. Emerging technologies of 3D printing have potential to realize a vertically stacking the microchannels and miniaturization of bulky microreaction accessories. When the advanced microreaction systems are integrated with newly developed microseparation technologies, automated synthesis of industrial compounds, such as pharmaceuticals which need multiple types of salification chemistry, will be almost completed. Many opportunities are open to developing innovative microreaction systems with these techniques that can also be highly durable under harsh conditions.
Maceió nos Jornais: transformações urbanas do riacho Maceió (1947-1949)
Authors: Barros Carlina Rocha de Almeida , Santos Caroline Gonçalves dos , Maia Roberta Félix , Carvalho Sibéria Freitas de 
Published: October 2017

Na cidade de Maceió (AL) o riacho Maceió teve presença marcante no início da ocupação urbana, caracterizando-se como elemento de importância paisagística e referencial do lugar. Com a crescente necessidade de expansão da cidade uma drástica mudança ocorreu no final da década de 1940, quando se iniciaram as obras de retificação do riacho afetando sua simbologia e apropriação, e alterando sua relação com o meio urbano. Propõe-se uma reflexão sobre um recorte do espaço urbano de Maceió a PARTIR de transformações que alteraram significativamente o curso do riacho e que foram noticiadas pelos jornais. Para isso foram levantadas reportagens acerca do riacho de 1947 a 1949 no intuito de colaborar no entendimento da mudança simbólica desse elemento natural e de suas relações com a sociedade.
História urbana. A configuração de um campo conceitual
Authors: Torrão Filho Amilcar 
Published: October 2017

Ao definir o espaço de constituição do capitalismo e da modernidade, Fernand Braudel, em seu clássico Civilização Material, Economia e Capitalismo, não hesita em afirmar a cidade como o lócus de construção histórica desta modernidade. As cidades são, para este autor, como transformadores elétricos: elas aumentam as tensões, precipitam as trocas, removem a vida dos homens. São nascidas da mais revolucionária divisão do trabalho: campo de um lado, atividades urbanas do outro. A cidade é cesura, ruptura, destino do mundo. Ao surgir com a escritura ela abre as portas para a história; quando renasce na Europa no séc. XI a ascensão do continente começa, quando ela floresce na Itália, é o Renascimento. Tão importante quanto seu conceito de longa duração, muitas vezes referenciado entre historiadores e cientistas sociais, Braudel ao dar tamanha importância ao espaço e à cidade também pensou num conceito que desse conta da dinâmica que envolve a cidade e a história, a pouco citada longa dimensão. A vida da cidade está associada a um espaço de longa dimensão, de onde vêm seus homens, onde estão suas relações comerciais, cidades, vilas e mercados que aceitam os seus pesos e medidas ou suas moedas, ou que falam a sua língua dialetal (s.d.: 560-1). De onde ela imperiosa, imperial e imperativamente tira seu sustento, sua mão-de-obra, seu exército industrial de reserva, seu poder. “No Ocidente, capitalismo e cidades, no fundo, são a mesma coisa”, afirma o historiador francês (s.d.: 586).
Tempo transversal
Authors: Costa Frederico Vergueiro 
Published: October 2017

Temáticas feministas e de gênero ganharam proeminência em publicações nos Estados Unidos no início dos anos 90. A tradução para o português, em 2006, da coletânea organizada por Kate Nesbitt, em 1995, viabilizou amplo acesso nacional aos debates teóricos dos centros especializados do Norte. Este artigo apresenta uma revisão bibliográfica de alguns destes textos e sugere potencialidades e limites para a historiografia da arquitetura e da cidade. A análise dos textos leva a uma concepção transversal da narrativa histórica a partir do olhar de diferentes sujeitos e dos atravessamentos do tempo cotidiano com o tempo histórico, do espaço sensível com o espaço construído.
Dysfibrinogenaemia secondary to rocuronium‐induced anaphylaxis
Authors: Orr Tim , Rosser Jon 
Published: October 2017

SummaryWe present a case of rocuronium‐induced anaphylaxis resulting in cardiac arrest that was complicated by the complete qualitative and quantitive absence of fibrinogen on viscoelastic and laboratory coagulation testing. The abnormalities resolved following the administration of fibrinogen concentrate. We review the literature and discuss the management of this uncommon complication of anaphylaxis.
A Discrete Choice Study of Patient Preferences for Dialysis Modalities
Authors: Walker Rachael C. , Morton Rachael L. , Palmer Suetonia C. , Marshall Mark R. , Tong Allison , Howard Kirsten 
Published: October 2017

Background and objectives
Improved knowledge about factors that influence patient choices when considering dialysis modality could facilitate health care interventions to increase rates of home dialysis. We aimed to quantify the attributes of dialysis care and the tradeoffs that patients consider when making decisions about dialysis modalities.

Design, setting, participants, & measurements
We conducted a prospective, discrete choice experiment survey with random parameter logit analysis to quantify preferences and tradeoffs for attributes of dialysis treatment in 143 adult patients with CKD expected to require RRT within 12 months (predialysis). The attributes included schedule flexibility, patient out of pocket costs, subsidized transport services, level of nursing support, life expectancy, dialysis training time, wellbeing on dialysis, and dialysis schedule (frequency and duration). We reported outcomes using β-coefficients with corresponding odds ratios and 95% confidence intervals for choosing home-based dialysis (peritoneal dialysis or hemodialysis) compared with facility hemodialysis.

Results
Home-based therapies were significantly preferred with the following attributes: longer survival (odds ratio per year, 1.63; 95% confidence interval, 1.25 to 2.12), increased treatment flexibility (odds ratio, 9.22; 95% confidence interval, 2.71 to 31.3), improved wellbeing (odds ratio, 210; 95% confidence interval, 15 to 2489), and more nursing support (odds ratio, 87.3; 95% confidence interval, 3.8 to 2014). Respondents were willing to accept additional out of pocket costs of approximately New Zealand $400 (United States $271) per month (95% confidence interval, New Zealand $333 to $465) to receive increased nursing support. Patients were willing to accept out of pocket costs of New Zealand $223 (United States $151) per month (95% confidence interval, New Zealand $195 to $251) for more treatment flexibility.

Conclusions
Patients preferred home dialysis over facility-based care when increased nursing support was available and when longer survival, wellbeing, and flexibility were expected. Sociodemographics, such as age, ethnicity, and income, influenced patient choice.
Comentarios sobre el libro: El mueble de madera dominicano, de la autoría de Angélica María Rodríguez Bencosme
Authors: Toirac Luis 
Published: October 2017

Este texto muestra la vida de Angélica María Rodríguez Bencosme, profesora de varias asignaturas de diseño, mobiliario y presupuesto, tanto en INTEC, como en UNIBE e INFOTEP.
Typology of the human organism system adaptation
Authors: Shatyr Yu. A. , Bulatetsky S. V. , Ulesikova I. V. , Mulik I. G. , Nazarova E. V. 
Published: October 2017

Transition to personalized medicine requires the systematization of possible scenarios of the human organism individual adaptation to exogenous shocks.
Objective: To identify and typology sustainable adaptation options to extreme environmental factors, taking into account individual, genetically determined functional properties of the human organism. As the object of the study, 146 people of both sexes were involved, 18-23 years of age. The work was performed in accordance with Articles 5, 6 and 7 of "The Universal Declaration on Bioethics and Human Rights" with the informed consent registration. As a result of complex theoretical and experimental researches the typology of the human organism system adaptation to extreme exogenous influences is designed. At the same time, stable combinations of functional properties phenotypic manifestations for individuals with high, medium and low level of general non-specific reactivity are systematized. Revealed expressed specific manifestations of the variation pulsometry main indicators depending on the individual level of general non-specific reactivity of an organism, where the prevalence of the sympathetic component of the autonomic nervous system is characteristic for people with high reactivity level and parasympathetic – for individuals with a low reactivity level. It was determined that an emergency exercise stress in individuals with a high level of general non-specific reactivity is a risk factor for sympathicotonia that gives them increased stress reactivity. Taken studies have proved the feasibility of separation of three types of the adaptation process. 1. The syntoxic process, which is typical for low level of general non-specific reactivity. 2. An integrated process inherent to the medium level of reactivity. 3. Catatoxic process, which is typical for a high level of general non-specific reactivity of an organism. The proposed typology is based on the account: the background level of general non-specific reactivity; specificity and speed of adaptation development; vegetative balance; dynamics of nociceptive sensitivity; psycho-emotional state of a person. Using the developed typology allows to individualize an assessment, forecasting and correction of the functional organism state that will provide personalization of health-support a person in high ambient load.
Polymorphism of nitric oxide synthase genes (NOS1 84G/A AND NOS3 786C/T) in patients with bronchial asthma and essential hypertension
Authors: Shakhanov A. V. , Nikiforov A. A. , Uryasyev O. M. 
Published: October 2017

There exists an interest in studying polymorphism of nitric oxide synthase genes in patients with bronchial asthma and essential hypertension.
Aim: to study clinical and pathogenetic significance of polymorphism of nitric oxide synthase genes (NOS1 84G/A and NOS3 786C/T) in formation of comorbid pathology of bronchial asthma and essential hypertension.
Materials and methods: in the study 71 patients participated who were treated for bronchial asthma or essential hypertension. The main group consisted of 24 patients with comorbid pathology of bronchial asthma and essential hypertension. The group of patients with isolated bronchial asthma included 23 individuals. The group of patients with isolated essential hypertension included 24 individuals. In all patients polymorphism of nitric oxide synthase genes NOS1 84G/A and NOS3 786C/T was determined.
Results: the studied groups did not differ in distribution of the genotypes (χ2=2.13, p=0.712) of NOS1 84G/A polymorphism. The studied groups reliably differed in distribution of alleles (χ2=10.55, p=0.005) and of separate genotypes (χ2=10.49, p=0.03) of NOS3 786C/T polymorphism which evidences the relationship between the given polymorphism and development of bronchial asthma and essential hypertension. In patients with comorbid pathology of bronchial asthma and essential hypertension the frequency of occurrence of T-allele is higher and that of C-allele is lower (χ2=4.24, p=0.04) than in patients with isolated bronchial asthma. T-allele of NOS3 786C/T polymorphism 2.4 times increases the probability for comorbid pathology of bronchial asthma and essential hypertension in comparison with isolated bronchial asthma (OR=2.40, 95% CI: 1.04-5.56).
Conclusion: evaluation of NOS3 786C/T polymorphism can be used for identification of patients with bronchial asthma with a high risk for development of essential hypertension.
Evaluation of Survival Rate and Pattern of Risk Factors and Recurrence Rate in Patients with Triple-Negative Breast Cancer with other Subtypes
Authors: Mortazavizadeh Seyed Mohammad Reza , Bashardoost Nasrollah , Kargar Saeed , Yazdanpanah Raziyeh 
Published: October 2017

Introduction: Breast cancer nowadays is one the major health issue especially in industrial population. Despite excessive researches in this regard, there is still no detailed and relevant information on the association between the risk factors of this cancer and its many outcomes. Due to increasing rate of breast cancer in Iran, including Yazd city, the present study was designed to evaluate the relationship between survival and recurrence rate with pattern of risk factors in breast cancer patients.Methods: This analytical study was conducted retrospectively on 333 patients with breast cancer during 8 years (2005-2013). Total survival and recurrence rates recorded in month for all samples, and then were analyzed and compared other obtained data. Chi-square and log rank were selected tests for analyzing and Kaplan-Meier was applicable curve for survival analyzing.Results: The mean age of subjects was 57.02 ± 12.32 years. The mean total survival rate was 93.15 ± 1.25 months (97.9%). The mean total recurrence rate was 84.59 ± 1.91 months (89.8%). The subgroups of breast cancer had no significant relationship with risk factors (P>0.05) though BMI and recurrence rate had significant relationship (P=0.045). Other risk factors had no significant relationship with total survival and recurrence rates. The mean duration of OCP (oral contraceptive pill) consumption was significantly more in the patients with ER-PR-Her2+ subgroup than other groups (P=0.03). Conclusion: According the findings, BMI lower than 25 is strong prognostic factor for recurrence rate in patients with triple-negative breast cancer. Because of high survival rate of patients with breast cancer during eight years, it is recommended to study on high survival period with larger sample sizes for accessing reliable evidence.