bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-Wide Association Study Meta-Analysis of Long-Term Average Blood Pressure in East Asians
Authors: Li Changwei , Kim Yun Kyoung , Dorajoo Rajkumar , Li Huaixing , Lee I-Te , Cheng Ching-Yu , He Meian , Sheu Wayne H-h , Guo Xiuqing , Ganesh Santhi K. , He Jiang , Lee Juyoung , Liu Jianjun , Hu Yao , Rao Dabeeru C. , Tsai Fuu-Jen , Koh Jia Yu , Hu Hua , Liang Kae-Woei , Palmas Walter , Hixson James E. , Han Sohee , Teo Yik-Ying , Wang Yiqin , Chen Jing , Lu Chieh Hsiang , Zheng Yingfeng , Gui Lixuan , Lee Wen-Jane , Yao Jie , Gu Dongfeng , Han Bok-Ghee , Sim Xueling , Sun Liang , Zhao Jinying , Chen Chien-Hsiun , Kumari Neelam , He Yunfeng , Taylor Kent D. , Raffel Leslie J. , Moon Sanghoon , Rotter Jerome I. , Ida Chen Yii-der , Wu Tangchun , Wong Tien Yin , Wu Jer-Yuarn , Lin Xu , Tai E-Shyong , Kim Bong-Jo , Kelly Tanika N. 
Published: March 2017

Background—
Genome-wide single marker and gene-based meta-analyses of long-term average (LTA) blood pressure (BP) phenotypes may reveal novel findings for BP.

Methods and Results—

We conducted genome-wide analysis among 18 422 East Asian participants (stage 1) followed by replication study of ≤46 629 participants of European ancestry (stage 2). Significant single-nucleotide polymorphisms and genes were determined by a
P
<5.0×10
−8
and 2.5×10
−
6
, respectively, in joint analyses of stage-1 and stage-2 data. We identified 1 novel
ARL3
variant, rs4919669 at 10q24.32, influencing LTA systolic BP (stage-1
P
=5.03×10
−
8
, stage-2
P
=8.64×10
−
3
, joint
P
=2.63×10
−
8
) and mean arterial pressure (stage-1
P
=3.59×10
−
9
, stage-2
P
=2.35×10
−
2
, joint
P
=2.64×10
−
8
). Three previously reported BP loci (
WBP1L
,
NT5C2
, and
ATP2B1
) were also identified for all BP phenotypes. Gene-based analysis provided the first robust evidence for association of
KCNJ11
with LTA systolic BP (stage-1
P
=8.55×10
−
6
, stage-2
P
=1.62×10
−
5
, joint
P
=3.28×10
−
9
) and mean arterial pressure (stage-1
P
=9.19×10
−
7
, stage-2
P
=9.69×10
−
5
, joint
P
=2.15×10
−
9
) phenotypes. Fourteen genes (
TMEM180
,
ACTR1A
,
SUFU
,
ARL3
,
SFXN2
,
WBP1L
,
CYP17A1
,
C10orf32
,
C10orf32
-
ASMT
,
AS3MT
,
CNNM2
, and
NT5C2
at 10q24.32;
ATP2B1
at 12q21.33; and
NCR3LG1
at 11p15.1) implicated by previous genome-wide association study meta-analyses were also identified. Among the loci identified by the previous genome-wide association study meta-analysis of LTA BP, we transethnically replicated associations of the
KCNK3
marker rs1275988 at 2p23.3 with LTA systolic BP and mean arterial pressure phenotypes (
P
=1.27×10
−
4
and 3.30×10
−
4
, respectively).

Conclusions—

We identified 1 novel variant and 1 novel gene and present the first direct evidence of relevance of the
KCNK3
locus for LTA BP among East Asians.
Transgender Phonosurgery: A Systematic Review and Meta‐analysis
Authors: Song Tara Elena , Jiang Nancy 
Published: March 2017

ObjectivesDifferent surgical techniques have been described in the literature to increase vocal pitch. The purpose of this study is to systematically review these surgeries and perform a meta‐analysis to determine which technique increases pitch the most.Data SourcesCINAHL, Cochrane, Embase, Medline, PubMed, and Science Direct.Review MethodsA systematic review and meta‐analysis of the literature was performed using the CINAHL, Cochrane, Embase, Medline, PubMed, and Science Direct databases. Studies were eligible for inclusion if they evaluated pitch‐elevating phonosurgical techniques in live humans and performed pre‐ and postoperative acoustic analysis. Data were gathered regarding surgical technique, pre‐ and postoperative fundamental frequencies, perioperative care measures, and complications.ResultsTwenty‐nine studies were identified. After applying inclusion and exclusion criteria, a total of 13 studies were included in the meta‐analysis. Mechanisms of pitch elevation included increasing vocal cord tension (cricothyroid approximation), shortening the vocal cord length (cold knife glottoplasty, laser‐shortening glottoplasty), and decreasing mass (laser reduction glottoplasty). The most common interventions were shortening techniques and cricothyroid approximation (6 studies each). The largest increase in fundamental frequency was seen with techniques that shortened the vocal cords. Preoperative speech therapy, postoperative voice rest, and reporting of patient satisfaction were inconsistent. Many of the studies were limited by low power and short length of follow‐up.ConclusionsMultiple techniques for elevation of vocal pitch exist, but vocal cord shortening procedures appear to result in the largest increase in fundamental frequency.
Separation of two sub-groups with different DNA content after treatment of T-47D breast cancer cells with low dose-rate irradiation and intermittent hypoxia
Authors: Mikalsen Stine Gyland , Jeppesen Edin Nina , Sandvik Joe Alexander , Pettersen Erik Olai 
Published: March 2017

Background Previous studies have shown that combined treatment with internal ultra-low dose-rate irradiation selectively inactivated hypoxic T–47D breast cancer cells after three to five weeks of treatment. However, 2–3% of the hypoxic cells were found to survive and restart proliferation upon re-oxygenation. Purpose To investigate the metastatic potential and characteristics of radiosensitivity of these surviving cells, named T – 47 DS. Material and Methods The T – 47 DS cells were grown in ambient air without irradiation. A cloning experiment identified two sub-groups with different DNA content ([Formula: see text] and [Formula: see text]). Furthermore, radiosensitivity and presence of hyper-radiosensitivity (HRS) was measured by Co-60 challenge irradiation and relative migration was determined by scratch assays. Results The two subpopulations of T – 47 DS had different DNA content; one had abnormally high DNA content ([Formula: see text]) and one had DNA content similar to wild-type T–47D cells ([Formula: see text]). HRS was surprisingly present in cells of the cloned population [Formula: see text], but was absent in cells of both [Formula: see text] and T – 47 DS. The radio response of T – 47 DS, [Formula: see text] at higher radiation doses were similar to that of T-47D cells, and neither subpopulation showed increased migration compared with wild-type T–47D. Conclusion No increase in the risk of metastasis was found and only slight changes in radiosensitivity in response to conventional clinical doses was observed. Thus, the data suggest that if ultra-low dose-rate irradiation is used for targeting the hypoxic tumor fraction, conventional high dose-rate irradiation can be used to eradicate eventual surviving cells as well as cells in the well oxygenated areas of the tumor.
Silencing of bach1 gene by small interfering RNA–mediation regulates invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor in MDA-MB-468 breast cancer cells
Authors: Mohammadzadeh Reza , Saeid Harouyan Mojgan , Ale Taha Seyed Mansour 
Published: March 2017

Background: Recently experimental validation of the networks revealed bach1, a basic leucine zipper transcription factor, as the common regulator of several functional invasive genes. The expression of bach1 and its target genes was linked to the higher risk of breast cancer recurrence in patients. The aim of this study was to investigate the effect of specific bach1 small interfering RNAs, on the invasive and expression level of miR-203, miR-145, matrix metalloproteinase-9, and CXCR4 receptor which play a role in cancer metastasis, in MDA-MB-468 cell lines. Methods: Small interfering RNA transfection was performed with transfection regent. The survival effects of small interfering RNA were determined using trypan blue assay cells. The expression level of messenger RNA and matrix metalloproteinase-9 to assess cell invasion and the expression level of miR-203, miR-145, and CXCR4 receptor were measured by quantitative real-time polymerase chain reaction analysis on the MDA-MB-468 cell lines. Results: Transfection with small interfering RNA significantly suppressed the expression of bach1 gene in dose-dependent manner after 48 h ( p < 0.0001). A significant reduction in cell invasion and CXCR4 receptor, matrix metalloproteinase-9 expression were observed ( p < 0.0001). It was also a dramatic increase in the expression level of miR-203 and miR-145 ( p < 0.0001). Conclusions: Our results suggest that the bach1-specific small interfering RNA effectively decrease CXCR4 receptor, matrix metalloproteinase-9 expression and breast adenocarcinoma cells invasive, also increased the expression of tumor-suppressive microRNA-203 and miR-145. Thus, these microRNAs may play a role in invasive/metastasis of carcinogenic breast cancer cells. Therefore, bach1 knockdown can be considered as a potent adjuvant in breast cancer therapy.
Complex PTSD – a better description for borderline personality disorder?
Authors: Kulkarni Jayashri 
Published: March 2017

Objective: To consider the use of the diagnostic category ‘complex posttraumatic stress disorder’ (c-PTSD) as detailed in the forthcoming ICD-11 classification system as a less stigmatising, more clinically useful term, instead of the current DSM-5 defined condition of ‘borderline personality disorder’ (BPD). Conclusions: Trauma, in its broadest definition, plays a key role in the development of both c-PTSD and BPD. Given this current lack of differentiation between these conditions, and the high stigma faced by people with BPD, it seems reasonable to consider using the diagnostic term ‘complex posttraumatic stress disorder’ to decrease stigma and provide a trauma-informed approach for BPD patients.
An m-Health system for education and motivation in cardiac rehabilitation: the experience of HeartCycle guided exercise
Authors: Salvi Dario , Ottaviano Manuel , Muuraiskangas Salla , Martínez-Romero Alvaro , Vera-Muñoz Cecilia , Triantafyllidis Andreas , Cabrera Umpiérrez Maria Fernanda , Arredondo Waldmeyer Maria Teresa , Skobel Erik , Knackstedt Christian , Liedes Hilkka , Honka Anita , Luprano Jean , Cleland John GF , Stut Wim , Deighan Carolyn 
Published: March 2017

Introduction Home-based programmes for cardiac rehabilitation play a key role in the recovery of patients with coronary artery disease. However, their necessary educational and motivational components have been rarely implemented with the help of modern mobile technologies. We developed a mobile health system designed for motivating patients to adhere to their rehabilitation programme by providing exercise monitoring, guidance, motivational feedback, and educational content. Methods Our multi-disciplinary approach is based on mapping “desired behaviours” into specific system’s specifications, borrowing concepts from Fogg’s Persuasive Systems Design principles. A randomised controlled trial was conducted to compare mobile-based rehabilitation (55 patients) versus standard care (63 patients). Results Some technical issues related to connectivity, usability and exercise sessions interrupted by safety algorithms affected the trial. For those who completed the rehabilitation (19 of 55), results show high levels of both user acceptance and perceived usefulness. Adherence in terms of started exercise sessions was high, but not in terms of total time of performed exercise or drop-outs. Educational level about heart-related health improved more in the intervention group than the control. Exercise habits at 6 months follow-up also improved, although without statistical significance. Discussion Results indicate that the adopted design methodology is promising for creating applications that help improve education and foster better exercise habits, but further studies would be needed to confirm these indications.
Safe and Inclusive Research Practices for Qualitative Research Involving People with Dementia: A Review of Key Issues and Strategies
Authors: Novek Sheila , Wilkinson Heather 
Published: March 2017

Aim Developing strategies to ensure the safe participation of people with dementia in research is critical to support their wider inclusion in research and to advance knowledge in the areas of dementia policy and practice. Objectives This literature review synthesizes and critically appraises different approaches to promote the safe participation of people with dementia in qualitative research. Methods Two databases were searched for articles that discuss the methodological or ethical aspects of qualitative research involving people with dementia. We did not focus on informed consent or ethical review processes as these have been reviewed elsewhere. Findings Key issues that impact participant safety include: language, gatekeepers, the research relationship, communication, dealing with distress, knowledge dissemination, and researcher skills. Conclusion By synthesizing different approaches to safety and highlighting areas of debate, we hope to advance discussion and to contribute to the development of inclusive research methods.
The impact of focused echocardiography using the Focused Intensive Care Echo protocol on the management of critically ill patients, and comparison with full echocardiographic studies by BSE-accredited sonographers
Authors: Hall David P , Jordan Helen , Alam Shirjel , Gillies Michael A 
Published: March 2017

Introduction Focused echocardiography is widely used to assist clinical decision-making in critically ill patients. In the UK, the Focused Intensive Care Echo protocol is recommended by the Intensive Care Society to ensure consistency of approach and guarantee training standards. Concerns remain about the reliability of information attained by non-expert clinicians in focused echocardiography, particularly when this is used to alter clinical management. Methods A prospective, observational evaluation of 60 consecutive patients undergoing Focused Intensive Care Echo studies in a single ICU. Results A complete Focused Intensive Care Echo study was possible in 43/60 scans (72%) and new diagnostic information obtained following 41/60 scans (68%), which lead to a change of clinical management in 28/60 (47%) of cases. In 24/60 (40%) of cases, a full transthoracic study was subsequently undertaken by a fully accredited sonographer. There were no cases where the results from the full study contradicted those from the limited Focused Intensive Care Echo study; additional diagnostic information was attained following 68% of full studies. Conclusion Focused echocardiography using the Focused Intensive Care Echo protocol is feasible and clinically useful in a high proportion of ICU patients. However, many still require additional expert echocardiographic assessment. Focused echocardiography delivered by non-experts is clinically useful in this setting but its limitations must be understood and access to expert assessment should be available.
Endoglin: a novel target for therapeutic intervention in acute leukemias revealed in xenograft mouse models
Authors: Dourado Keina M. C. , Baik June , Oliveira Vanessa K. P. , Beltrame Miriam , Yamamoto Ami , Theuer Charles P. , Figueiredo Camila A. V. , Verneris Michael R. , Perlingeiro Rita C. R. 
Published: March 2017

Key Points
Leukemia-forming activity is enriched in endoglin-expressing AML and B-ALL blasts using a mouse xenograft model. Inhibition of endoglin function with TRC105 reduces leukemia development and progression.
DNACPR (‘do not attempt cardiopulmonary resuscitation’) orders in patients with a fractured neck of femur who lack capacity
Authors: Hill DS , Nazar L , Freudmann M 
Published: March 2017

Nationally, half of all deaths occur in hospital, with 94% having a ‘do not attempt cardiopulmonary resuscitation’ (DNACPR) notice in place at the time of death. Recent court rulings have raised the profile of practices surrounding DNACPR orders where patients lack capacity. Failure to consult with those close to the patient in relation to DNACPR decisions is a breach of the right to respect for private and family life under article 8 of the Human Rights Act. A report from 2016 found that those close to the patient were not consulted before one out of every five DNACPR orders are placed. We advocate addressing the issue of resuscitation in patients with a fractured neck of femur who are approaching the end of their lives. Where the patient lacks capacity, there is a legal duty to consult with those close to the patient where it is practicable and appropriate to do so. There must be a convincing and well evidenced reason to proceed without consultation, and the orthopaedic surgeon should exercise extreme caution before doing so.
L’Algerie: une region mediterraneene tres sensible aux incendies de foret
Authors: Zahira Souidi , Hadj Benbakar 
Published: March 2017

Comme dans de nombreux pays de la Méditerranée, les zones boisées en Algérie sont soumises à un risque récurrent des incendies de forêt qui est favorisée par l'extrême inflammabilité des espèces forestières méditerranéennes durant l'été. Ce travail tente de clarifier l'évolution et les causes des feux de forêt en Algérie et de donner un aperçu des efforts déployés au niveau national pour réduire le risque d'incendie de forêt. https://doi.org/10.14195/1647-7723_24_13
O tempo de resposta do ataque inicial a incêndios florestais nos espaços mais sensíveis de Portugal: o exemplo prático da serra da Lousã
Authors: Félix Fernando , Lourenço Luciano 
Published: March 2017

A ocorrência de incêndios florestais necessita da conjugação de condições atmosféricas favoráveis, vegetação combustível e uma fonte de ignição. Reunidas estas três condições, os incêndios florestais começam, normalmente, por ser pequenas fogueiras. Depois, a reposta do ataque inicial determina, quase sempre, as características que os incêndios acabam por assumir, pelo que o tempo necessário para essa resposta deverá estar em consonância com as características intrínsecas a cada um dos espaços florestais, para assim se mitigarem as consequências e reduzirem as dimensões das áreas ardidas. https://doi.org/10.14195/1647-7723_24_14
Risco de inundações urbanas em Mirandela e o ordenamento do seu território como forma de prevenção
Authors: Gouveia Maria , Lourenço Luciano 
Published: March 2017

A ocorrência de inundações na cidade de Mirandela é um fator condicionante da vida dos cidadãos que aí residem, trabalham ou lá se deslocam para a visitar. Para melhor conhecer este risco, decidiu-se estudar a influência do processo de urbanização na manifestação das cheias e consequentes inundações. Pretende-se, assim, contribuir para uma mais eficaz proteção de pessoas, animais e bens patrimoniais. https://doi.org/10.14195/1647-7723_24_18
Fatores condicionantes dos processos erosivos na sub-bacia hidrográfica de Água de Gato – Cabo Verde
Authors: Sanches Filipe Gomes , Carvalho Ineida Romi Tavares Varela de , Vieira António 
Published: March 2017

O presente trabalho, realizado na Sub-Bacia Hidrográfica de Água de Gato-Concelho de São Domingos, teve como objetivo fundamental o diagnóstico e a aferição dos processos erosivos aí presentes. Os resultados do estudo indiciam que a ocorrência dos processos erosivos na área de estudo não é devida exclusivamente aos processos naturais, sendo que as práticas tradicionais de uso e gestão do solo praticadas nessa área, são significativamente influentes, especialmente por ocorrerem em encostas com declives acentuados e onde estão ausentes práticas adequadas de conservação de solo. https://doi.org/10.14195/1647-7723_24_4
Vom sanktionierten Pariastaat zum Joint-Venture der Welt. Aspekte der ökonomischen Dynamik Myanmars
Authors: Mahnkopf Cordula Meyer 
Published: March 2017

Abstract
Due to its internationally accompanied opening policies, Myanmar’s present economic situation is unique even on a global scale. The present contribution addresses the question if the ranking of Mynamar on position 150 of the UN Human Development Index indeed reflects the country’s economic situation. The paper investigates the historical developments in Myanmar after 1948, the Western sanctions regime after 1988, the integration into ASEAN, the present framework for ‘doing business’, and the dynamics of foreign capital and domestic labor conditions. The paper concludes that the years of political isolation and repression still inhibit the country’s fast economic progress. The future welfare of this politically disrupted country so rich in natural resources does not only depend on its government and its ascending civil society, but also on FDI by foreign companies.
“You Don’t Wear a Fur in Summer”: Kang Youwei’s Impartial Words on Republicanism (1917) and the Fate of Chinese Democracy
Authors: Brusadelli Federico 
Published: March 2017

Abstract
This article aims to discuss Kang Youwei’s 康有為 (1858–1927) position on democracy and republicanism in China through the analysis of two major works of his late production: Datongshu 大同書 (Book of Great Concord, drafted in 1902, but only published posthumously in 1935) and Gonghe Pingyi 共和評議 (Impartial Words on Republicanism, 1917), seemingly presenting two opposite views on the same issue. Whereas in his most “esoteric” production, represented by the Datongshu, Kang prophesied the spread of democracy on a global scale (China included), he remained loyal to the prospect of a Chinese constitutional monarchy in his public appearances after 1911 – the same he had abortively sponsored during the Hundred Days’ Reform of 1898. In 1917, playing an active role in the short and somehow farcical restoration of the last Manchu emperor on the throne orchestrated by warlord Zhang Xun, Kang published Impartial Words on Republicanism, a significant essay through which he intended to explain the apparent contradiction between his republican utopia on the one hand and his “imperial” project on the other. Through the translation and discussion of some extracts from the two aforementioned works, I will try to shed more light on Kang’s complex views on the issue and on the ambivalence of his political and theoretical agenda. Finally, I will also suggest that Kang’s reflections may appear to have been successively echoed by later intellectuals in the debate on the possibility and nature of a “Chinese democracy”.
Se servir de la fiction comme guide: l’exemple des « romans de carrière » chinois contemporains
Authors: Gonseth Morgane 
Published: March 2017

Abstract
This paper focuses on « workplace novels », a literary genre which emerged in the 2000s in Mainland China, as well as on the various discourses surrounding these works by editors, publicists, and scholars. Even though some novels of this category have enjoyed a significant popular and commercial success, the attention they attract in the academic circles seems out of proportion when compared with the actual production of the genre. Moreover, the advertisement and academic discourses concerning these texts have proven to be highly congruent, even stereotyped, as they all describe workplace novels as the career guides of the young urban white-collar workers who are supposed to read them. This congruence is all the more surprising when considering that the information and advice that these novels are supposed to offer do not seem specific nor concrete enough to be applied in a real situation. This paper proposes to address this ambivalence, as well as its origins and implications.
Le commentaire de Tankuang sur l’Eveil à la Foi dans le Grand Véhicule: la probable influence de Wonhyo
Authors: Guerra-Glarner Monika 
Published: March 2017

Abstract
Tankuang was a Chinese monk active during the eighth century. His texts were found in Dunhuang at the beginning of the twentieth century, and only then included in the Taishō canon. Tankuang wrote several commentaries on numerous Mahāyāna sutras, and two of these texts are commentaries on the Dasheng qixin lun. This paper focuses on the influence of two Korean monks, Wonch’uk and Wonhyo, on Tankuang’s commentaries. Whereas it seems clear that Tankuang was affiliated to the Ximing lineage of Wonch’uk, there is no such evidence concerning the influence of Wonhyo. But it appears that Tankuang is taking over some of the concepts introduced by Wonhyo, and there are some clear cases of textual and doctrinal evidence of this influence that I will present in this paper.