bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perinatal interventions to prevent Adverse Childhood Experiences (ACEs): A scoping review
Authors: Kinsey Jane , La Charite Jaime , Russ Shirley , Schickedanz Adam 
Published: October 2024

Background
Preventing Adverse Childhood Experiences (ACEs) is a public health priority, and the perinatal period is a sensitive life stage when preventive interventions could be particularly effective. Protecting and buffering pregnant persons and infants from exposure to adversity can optimize children’s development and health trajectories, reduce future morbidity and mortality, and even break intergenerational cycles of adversity, but no study has synthesized experimental evidence on effectiveness of interventions to address ACEs in the perinatal period.

Objectives
To (1) identify perinatal ACE prevention interventions, tested in high quality randomized control trials, with a dyadic perspective examining outcomes for mother and child; (2) describe their (a) place on the public health prevention continuum and (b) incorporation of life course characteristics that aim to optimize life health trajectories; and (3) determine which interventions show evidence of effectiveness.

Methods
We undertook a scoping review, using a modified PRISMA-Sc approach, of articles published in English between January 2000 and November 2023 identified through Psych info and PubMed using search terms for a broad range of adversities, with additional capture of articles from relevant reference lists. Interventions were included if they targeted an identified ACEs exposure or risk; were tested in randomized controlled trials (RCTs); reported outcome measures for both mother and child and were initiated during pregnancy. Interventions were further analyzed using the public health prevention continuum and Life Course Intervention Research (LCIR) characteristics frameworks. A two-tailed t test was used to ascertain the association between LCIR characteristics, and the outcomes achieved.

Results
Of 2148 articles identified, 57 were in scope for detailed analysis, yielding 53 unique interventions. Overall, 42 (74%) reported some positive impact; 37 (65%) for mothers; 37 (65%) for the child, and 32 (56%) for both. Interventions with the strongest evidence based on study quality and reported outcomes were co-parenting programs designed to improve the quality and function of the co-parenting relationship, home visiting interventions, and integrative health interventions incorporating baby massage and/or yoga. Half of effective interventions were secondary prevention focused. The mean number of life course characteristics was significantly higher in the studies that reported a positive impact on the mother and/or child (p = 0.003).

Conclusions
Few studies specifically addressed ACEs as a defined set of adversities, yet a range of perinatal interventions showed positive impacts on individual ACE risks or exposures. Intentional incorporation of life course characteristics and bundling of evidence-based components into comprehensive perinatal interventions hold promise for future ACEs prevention.
Selection of primary health care quality indicators in Europe: A Delphi study protocol
Authors: Lobo Mariana , Pinto Andreia , Conceição Glória , Escadas Sara , de Medeiros Adriane Mesquita , Dias Bruna , Sousa Pinto Marta , Pinto Emília , Ramalho André , Pereira António , Gonçalves Pinho Manuel , Castro Pedro , Pinheiro Vera , Santos Paulo , Santos João Vasco , Freitas Alberto 
Published: October 2024

Objective
To describe a protocol to achieve consensus on valid and important indicators to assess primary health care (PHC) quality regarding all clinical contexts of PHC in European health systems.

Study design
Qualitative study using the Delphi technique to gain consensus among European panels of experts comprising a heterogeneous professional background.

Methods
Potential candidate indicators were extracted and translated according to a set of informative elements (i.e., name, description, formula, unit of analysis, and sources). This list was then independently reviewed, and duplicates were removed totaling 1726 indicators. To guarantee a good response rate, indicators were distributed across 57 Delphi panels organized by clinical context. Each panel is a Delphi process, assessing between 23 to 33 indicators. Experts’ opinions on the validity and importance of the extracted indicators will be obtained through two rounds of online questionnaires, using a 9-point Likert scale and free-text boxes. To prevent biased responses, participation will be anonymous to other participants and to the team administrating panels. Consensus will be considered if at least 70% of ratings (≥7 assuming 10 participants) lie within the 7–9 range and less than 15% of ratings (<2 assuming 10 participants) are in the 1–3 range. Analysis of results will be streamlined and generalizable across panels using scripts.

Conclusions
This protocol will contribute to improve the quality of PHC in Europe by achieving a consensual and concise list of PHC quality indicators retrieved from the scientific literature that fit current clinical guidelines and populations’ needs in countries from the European region according to the World Health Organization.
Human umbilical cord mesenchymal stem cells toxicity and allergy effects: In vivo assessment
Authors: Cheng Wu Dong , Bin Luo , Lin Zuo Xia , Yu Ding , Xiang Ding Ke , Lo Samantha , Ravichandran Manickam , Kong Tham Seng 
Published: October 2024

Objective
Human umbilical cord mesenchymal stem cells (hUCMSCs) hold significant promise across various clinical applications. Therefore, regulatory requirements necessitate a thorough investigation of the hUCMSCs safety before clinical trials and potential allergic reactions after transplantation.

Methods
Abnormal toxicity test employed mice and guinea pigs dosed daily at 0.5×106 cells and 5×106 cells, respectively for 7 days. Acute toxicity test employed low, medium, and high doses of hUCMSCs injected into mice once, followed by observations for 23 days. In systemic allergy test, guinea pigs received low and high dose of hUCMSCs, with sensitization and excitation stages at day 14 and 21, respectively.

Results
The abnormal toxicity test of hUCMSC injections revealed no abnormal reactions over a seven-day observation period, indicating the safety of this administration route. In acute toxicity studies, the high-dose hUCMSCs group resulted in fatalities due to pulmonary embolism. Conversely, the low-dose group exhibited no toxic reactions or deaths. The maximum tolerated dose was determined to be >2×107 cells/kg. Systemic active allergy test showed that high doses of hUCMSC intravenous injections did not induce allergic reactions.

Conclusion
This research affirms hUCMSC injections meet safety standards for clinical cell therapy, emphasizing their safe and promising clinical utility.
Demonstration of physicochemical and functional similarity between Stimufend (pegfilgrastim-fpgk) and Neulasta (pegfilgrastim): A comparative analytical assessment
Authors: Sykes Alison , Ingram Louise , Kronthaler Ulrich , Chevalet Laurent 
Published: October 2024

Background
Pegfilgrastim is a long-acting recombinant human granulocyte colony-stimulating factor biologic that is indicated to reduce the incidence of infections, manifested by febrile neutropenia, in patients receiving myelosuppressive anti-cancer drugs and to increase survival in patients acutely exposed to myelosuppressive doses of radiation. Due to the high cost of biologic therapy and the scarcity of biosimilar alternatives, there is an unmet medical need for targeted biologics.

Objective
This comparative analytical investigation aimed to confirm the similarity of biosimilar Stimufend® (pegfilgrastim-fpgk) to reference product Neulasta® (pegfilgrastim).

Methods
The analysis was designed using state-of-the-art orthogonal techniques and side-by-side testing to compare the physicochemical and biological properties of these two products. The measured quality attributes included the primary structure and higher order structure of the molecule, purity/impurity profiles, product variants, process-related impurities, composition, content, and biological activity. The statistical analysis was based on risk ranking of the critical quality attributes (very low, low, moderate, high, very high), and scientific considerations in combination with the characteristics of the assay (sensitivity, selectivity, and variability). In addition, non-quantitative parameters were compared using a descriptive assessment of the product profile. Analytical similarity was concluded by quality attributes falling within the defined range of the originator product.

Results
The results of this study confirm that Stimufend® is biosimilar to Neulasta® for all measured quality attributes. There are no clinically significant differences between Stimufend® and Neulasta®, which was confirmed by the marketing approval for Stimufend® by the Food and Drug Administration and the European Medicines Agency.

Conclusion
The findings of this study provide robust evidence supporting the structural and functional biosimilarity between Stimufend® and Neulasta®.
Informing climate-health adaptation options through mapping the needs and potential for integrated climate-driven early warning forecasting systems in South Asia—A scoping review
Authors: Asaaga Festus A. , Tomude Emmanuel S. , Rickards Nathan J. , Hassall Richard , Sarkar Sunita , Purse Bethan V. 
Published: October 2024

Background
Climate change is widely recognised to threaten human health, wellbeing and livelihoods, including through its effects on the emergence, spread and burdens of climate–and water-sensitive infectious diseases. However, the scale and mechanisms of the impacts are uncertain and it is unclear whether existing forecasting capacities will foster successful local-level adaptation planning, particularly in climate vulnerable regions in developing countries. The purpose of this scoping review was to characterise and map priority climate- and water-sensitive diseases, map existing forecasting and surveillance systems in climate and health sectors and scope out the needs and potential to develop integrated climate-driven early warning forecasting systems for long-term adaptation planning and interventions in the south Asia region.

Methods
We searched Web of Science Core Collection, Scopus and PubMed using title, abstract and keywords only for papers focussing on climate-and water-sensitive diseases and explicit mention of either forecasting or surveillance systems in south Asia. We conducted further internet search of relevant national climate adaptation plans and health policies affecting disease management. We identified 187 studies reporting on climate-sensitive diseases and information systems in the south Asia context published between 1992 and 2024.

Results
We found very few robust, evidenced-based forecasting systems for climate- and water- sensitive infectious diseases, which suggests limited operationalisation of decision-support tools that could inform actions to reduce disease burdens in the region. Many of the information systems platforms identified focussed on climate-sensitive vector-borne disease systems, with limited tools for water-sensitive diseases. This reveals an opportunity to develop tools for these neglected disease groups. Of the 34 operational platforms identified across the focal countries, only 13 (representing 38.2%) are freely available online and all were developed and implemented by the human health sector. Tools are needed for other south Asian countries (Afghanistan, Sri Lanka, Bhutan) where the risks of infectious diseases are predicted to increase substantially due to climate change, drought and shifts in human demography and use of ecosystems.

Conclusion
Altogether, the findings highlight clear opportunities to invest in the co-development and implementation of contextually relevant climate-driven early warning tools and research priorities for disease control and adaptation planning.
Prevalence and determinants of prehospital delay among stroke patients in mainland China: A systematic review and meta-analysis of the study protocol
Authors: Deng Hui , Wang Xiangming , Yin Li , Li Xianzhi , Zhang Yuehui 
Published: October 2024

Background
Prehospital delay is one of the most serious problems in the treatment of stroke patients. In China, although hospitals at all levels have promoted the construction of stroke centers, pre-hospital delays are still very common. As the primary cause of death and disability, stroke not only brings great harm to patients themselves, but also brings a heavy burden on social progress and economic development, it is important to understand the prevalence and determinants of prehospital delay among stroke patients. Therefore, this review aims to determine the pooled prevalence and determinants of prehospital delay in mainland China.

Methods
A systematic review of eligible articles will be conducted using preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. A comprehensive literature search will be conducted in PubMed, Embase, Cochrane, web of science, China National Knowledge Infrastructure (CNKI), Wanfang, Weipu (VIP) and Chinese Biomedicine Iiterature databas (CBM) databases. The quality of the articles included in the review will be evaluated using the Newcastle-Ottawa Scale (NOS). The pooled prevalence of prehospital delay, and odds ratio and their 95% confidence intervals for relevant influencing factors, will be calculated using RevMan 5.3 software. The existence of heterogeneity among studies will be assessed by computing p-values of Higgins’s I2 test statistics and Cochran’s Q-statistics. Sensitivity analysis and subgroup analysis will be conducted based on study quality to investigate the possible sources of heterogeneity. Publication bias will be evaluated by funnel chart and by Egger’s regression test. This review protocol has been registered PROSPERO (CRD42023484580).

Discussion
By collecting and summarizing information on prehospital delay among stroke patients can be a step towards a better understanding of the prevalence of prehospital delay among stroke patients in mainland China and how the associated factors influence the prevalence of prehospital delay. Therefore, a rapid, accurate diagnosis Stroke, timely pre-hospital first aid, the treatment process forward, for the patient It has great significance. This summarized finding at the national level will provide new clues for intervention to reduce the rate of pre-hospital delay of stroke patients, and is expected to further improve the treatment effect of stroke patients.
S3260 An Interesting Case of Lymphocytic Esophagitis In Association With Pityriasis LichenoidesChronica and Rheumatoid Arthritis
Authors: Menon Raakhi , Abdul-Baki Kian , Aburayyan Kanana , Thaker Harshwardhan , Al-Saadi Yamam 
Published: October 2024

Introduction:
Lymphocytic esophagitis (LyE) is a rare esophageal disorder of unknown etiology, characterized by dense peripapillary lymphocytes without neutrophils or eosinophils, and spongiosis. Patients typically present with symptoms such as dysphagia or chest pain. Here, we describe a notable case of lymphocytic esophagitis in a patient who presented with food impaction.

Case Description/Methods:
A 53-year-old woman with a history of pityriasis lichenoideschronica and rheumatoid arthritis reported chronic dysphagia and sought emergency care for food impaction. A subsequent upper endoscopy revealed a long submucosal tear in the upper esophagus during intubation (see Figure 1A), leading to the procedure's cessation. A follow-up upper endoscopy 9 weeks later, employing an ultra-slim scope, identified severe stenosis in the upper esophagus (see Figure 1B). Dilation was performed using a Savary dilator. Examination of the esophageal lining revealed edema, rings, and furrows. Proximal and distal esophageal biopsies were obtained, indicating a marked increase in intraepithelial lymphocytes, with an absence of eosinophils or neutrophils. The squamous epithelium exhibited evidence of spongiosis and necrotic keratinocytes, consistent with a diagnosis of lymphocytic esophagitis. The patient continued omeprazole 40 mg twice daily and started budesonide at 1 mg twice daily. A repeat upper endoscopy with esophageal biopsies demonstrated a significant improvement in lymphocytic infiltration (see Figure 2A-B).

Discussion:
LyE typically manifests in females during their 5th-6th decades, presenting a notable contrast to eosinophilic esophagitis (EOE), which predominantly affects males in their 2nd-3rd decades. However, the endoscopic appearance of LyE often mirrors that of EOE. Studies suggest potential associations between LyE and Crohn's disease in children, as well as primary esophageal dysmotility in adults. Notably, our patient has a history of rheumatoid arthritis, a correlation observed in 2 other cases in the literature. While limited literature exists on pityriasis lichenoideschronica with esophageal involvement, specifically presenting as LyE, this singular case underscores the interconnection of these 2 disease processes. These observations raise the possibility of an autoimmune etiology. There is no consensus on the lymphocyte count threshold for diagnosis, a challenge compounded by the rarity of the disease, leading to a lack of definitive guidelines for optimal management.

JOURNAL/ajgast/04.03/00000434-202410001-03261/figure1/v/2025-02-20T041334Z/r/image-tiff
Analisis Perbandingan Transportasi Sedimen Menggunakan Metode Granulometri pada Sungai Damar Section Hulu dan Hilir Kabupaten Kendal
Authors: Wicitra Annisa Puspa , Taufiqi Khoirul , Rianawati Ranita Fitri , Jayanti Anita Galih Ringga 
Published: October 2024

Granulometri merupakan analisis untuk mengidentifikasi ukuran butiran dan hubungannya dengan proses sedimentasi. Penelitian ini dilakukan di aliran Sungai Damar, Kabupaten Kendal, dengan dua titik lokasi pengambilan sampel, yaitu di hulu (Kecamatan Sukorejo) dan hilir (Kecamatan Weleri). Keterdapatan endapan sedimen material vulkanik, material batuan karbonat pada Formasi Kerek, dan aluvial yang terdapat di sepanjang aliran Sungai Damar menjadi cukup menarik untuk mengetahui proses transportasi sedimen berdasarkan ukuran butiran yang tertransportasi. Metode yang digunakan adalah analisis granulometri cara grafis, untuk mendapatkan nilai sortasi, Skewness, dan Kurtosis. Hasil penelitian menunjukkan aliran Sungai Damar melalui beberapa formasi, seperti Formasi Kaligetas, Formasi Kerek, Formasi Damar, dan Endapan Aluvium. Dari hasil perhitungan didapatkan nilai sortasi kedua sampel dengan sortasi sangat baik, nilai Skewness kedua sampel termasuk ke dalam strongly coarse skewed, sedangkan dari hasil Kurtosis pada bagian hulu termasuk platykurtic, sedangkan bagian hilir termasuk very leptokurtic. Dari hasil transportasi tersebut menunjukkan adanya faktor kontrol lain, seperti kondisi geologi, geomorfologi, dan hidrodinamika mempengaruhi proses transportasi sedimen di Sungai Damar. Formasi geologi pada bagian hulu tingkat erosi lebih tahan daripada bagian hilir. Geomorfologi mencakup bentuklahan struktural berbukit terjal di hulu dan landai di hilir. Hidrodinamika dengan pola aliran dendritik dan cabang sungai pendek yang mempengaruhi transportasi sedimen di wilayah tersebut. Pada bagian hulu, dominan traksi karena kemiringan lereng yang curam, sedangkan dominan saltasi di hilir karena kemiringan lereng yang lebih landai.
A comprehensive survey of artificial intelligence adoption in European laboratory medicine: current utilization and prospects
Authors: Cadamuro Janne , Carobene Anna , Cabitza Federico , Debeljak Zeljko , De Bruyne Sander , van Doorn William , Johannes Elias , Frans Glynis , Özdemir Habib , Martin Perez Salomon , Rajdl Daniel , Tolios Alexander , Padoan Andrea 
Published: October 2024

Abstract

Background
As the healthcare sector evolves, Artificial Intelligence’s (AI’s) potential to enhance laboratory medicine is increasingly recognized. However, the adoption rates and attitudes towards AI across European laboratories have not been comprehensively analyzed. This study aims to fill this gap by surveying European laboratory professionals to assess their current use of AI, the digital infrastructure available, and their attitudes towards future implementations.

Methods
We conducted a methodical survey during October 2023, distributed via EFLM mailing lists. The survey explored six key areas: general characteristics, digital equipment, access to health data, data management, AI advancements, and personal perspectives. We analyzed responses to quantify AI integration and identify barriers to its adoption.

Results
From 426 initial responses, 195 were considered after excluding incomplete and non-European entries. The findings revealed limited AI engagement, with significant gaps in necessary digital infrastructure and training. Only 25.6 % of laboratories reported ongoing AI projects. Major barriers included inadequate digital tools, restricted access to comprehensive data, and a lack of AI-related skills among personnel. Notably, a substantial interest in AI training was expressed, indicating a demand for educational initiatives.

Conclusions
Despite the recognized potential of AI to revolutionize laboratory medicine by enhancing diagnostic accuracy and efficiency, European laboratories face substantial challenges. This survey highlights a critical need for strategic investments in educational programs and infrastructure improvements to support AI integration in laboratory medicine across Europe. Future efforts should focus on enhancing data accessibility, upgrading technological tools, and expanding AI training and literacy among professionals. In response, our working group plans to develop and make available online training materials to meet this growing educational demand.
Causal inference with textual data: A quasi-experimental design assessing the association between author metadata and acceptance among ICLR submissions from 2017 to 2022
Authors: Chen Chang , Zhang Jiayao , Ye Ting , Roth Dan , Zhang Bo 
Published: October 2024

Abstract
Many recent studies have probed status bias in the peer-review process of academic journals and conferences. In this article, we investigated the association between author metadata and area chairs’ final decisions (Accept/Reject) using our compiled database of 5,313 borderline submissions to the International Conference on Learning Representations from 2017 to 2022 under a matched observational study framework. We carefully defined elements in a cause-and-effect analysis, including the treatment and its timing, pre-treatment variables, potential outcomes (POs) and causal null hypothesis of interest, all in the context of study units being textual data and under Neyman and Rubin’s PO framework. We found some weak evidence that author metadata was associated with articles’ final decisions. We also found that, under an additional stability assumption, borderline articles from high-ranking institutions (top-30% or top-20%) were less favored by area chairs compared to their matched counterparts. The results were consistent in two different matched designs (odds ratio = 0.82 [95% confidence interval (CI): 0.67 to 1.00] in a first design and 0.83 [95% CI: 0.64 to 1.07] in a strengthened design) and most pronounced in the subgroup of articles with low ratings. We discussed how to interpret these results in the context of multiple interactions between a study unit and different agents (reviewers and area chairs) in the peer-review system.