bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of cognitive-behavioral counseling on anxiety in the mothers of infants in the NICU: A randomized controlled trial
Authors: Koochaki Massumeh , Mahmoodi Zohreh , Esmaelzadeh – Saeieh Sara , Kabir Kourosh , Tehranizadeh Maryam , Dolatian Mahrokh 
Published: September 2017

Background: Pressures and tensions in everyone’s life can cause a wide range of mental disorders such as anxiety. One of these tensions is the birth of a baby who requires special care, which can cause personal and social problems for the mother if no appropriate measures are taken to help them. The present study was conducted to determine the effect of cognitive-behavioral counseling on anxiety in the mothers of infants in the Neonatal Intensive Care Unit. Methods: This randomized controlled trial recruited 90 women presenting to Kowsar Hospital in Qazvin in 2016. They were enrolled by convenience sampling and randomly assigned to control and intervention groups. Eight sessions were held for each group. Beck Anxiety Inventory was filled by mothers at the beginning of intervention, at the end of the eighth session and three weeks after the intervention. The data was analyzed by generalized estimating equations (GEE) method. Results: According to the results, maternal anxiety showed no significant differences between the two groups before intervention (p = 0.408 and p = 0.881). Based on GEE test, the mean score of anxiety was significantly different in the two groups (p = 0.026) immediately and three weeks after the intervention in that it was lower in the intervention group. Friedman test results also confirmed the reducing trend of mean score of anxiety in the three stages (p = 0.000). Conclusions: Counseling has a positive effect on reducing the anxiety of mothers of children with special needs, therefore it can be used to improve their condition.
­­­Proteomic analysis of H3K36me3 and PSIP1/p75 (LEDGF) complexes reveal their wider role in DNA repair
Authors: Pradeepa Madapura M. , Taylor Gillian C.A. , von Kriegsheim Alex 
Published: September 2017

Background: Trimethylation at histone H3 at lysine 36 (H3K36me3) is associated with expressed gene bodies and recruit proteins implicated in transcription, splicing and DNA repair. PC4 and SF2 interacting protein (PSIP1/LEDGF) is a transcriptional coactivator, possesses a H3K36me3 reader PWWP domain. Alternatively spliced isoforms of PSIP1 binds to H3K36me3 and suggested to function as adaptor proteins to recruit transcriptional modulators, splicing factors and proteins that promote homology directed repair (HDR), to H3K36me3 chromatin. Methods: We performed chromatin immunoprecipitation of H3K36me3 followed by quantitative mass spectrometry to identify proteins associated with H3K36 trimethylated chromatin in mouse embryonic stem cells (mESCs). Furthermore, we performed stable isotope labelling with amino acids in cell culture (SILAC) for a longer isoform of PSIP1 (p75) and MOF/KAT8 in mESCs and mouse embryonic fibroblasts (MEFS). Results: Proteomic analysis of H3K36me3 chromatin show association of proteins involved in transcriptional elongation, RNA processing and DNA repair with H3K36me3 chromatin. Furthermore, we show DNA repair proteins like PARP1, gamma H2A.X, XRCC1, DNA ligase 3, SPT16, Topoisomerases and BAZ1B are predominant interacting partners of PSIP1/p75. We validated the association of PSIP1/p75 with gamma H2A.X, an early marker of DNA damage and also demonstrated accumulation of damaged DNA in PSIP1 knockout MEFs. Conclusions: In contrast to the previously demonstrated role of H3K36me3 and PSIP1/p75 in promoting HDR in mammals, our data supports the wider role of H3K36me3 and PSIP1 in maintaining the genome integrity by recruiting several DNA repair proteins to transcribed gene bodies.
Meningkatkan Rentang Perhatian Anak Autis dalam Pembelajaran Pengenalan Huruf
Authors: Ballerina Titisa 
Published: September 2017

One characteristic of an autistic child is having obstacles in attention span, which affects their learning process. Children with autism need appropriate learning methods to help them engaging the learning process. This study is aimed at figuring out an appropriate learning method for the subject in recognizing letters. The main question of this study is how to improve the subject’s attention span in learning letter recognition. This case study was conducted through five processes, i.e.: (1) accessing the subject; (2) analyzing the problem; (3) preparing interventions for the subject; (4) implementing interventions; (5) evaluating the effects of interventions. The study found that the learning method of movement and song can enhance the autistic child’s attention span. Therefore, children with autism need appropriate learning methods based on their interests.[Salah satu karakteristik anak autis adalah memiliki hambatan dalam rentang perhatian, yang berdampak pada proses pembelajaran. Anak autis memerlukan metode belajar yang sesuai dengan karakteristiknya, agar dapat membantu proses belajarnya. Studi kasus ini bertujuan untuk mengetahui metode belajar yang sesuai untuk subjek dalam mengenal huruf. Pertanyaan utama pada penelitian ini adalah bagaimana cara meningkatkan rentang perhatian subjek dalam pembelajaran pengenalan huruf. Proses yang telah dilakukan yaitu: (1) mengases subjek; (2) menganalisis permasalahan; (3) menyusun intervensi untuk subjek; (4) menerapkan intervensi; (5) mengevaluasi efek intervensi. Kesimpulan dari studi ini adalah terdapat peningkatan rentang perhatian pada subjek, setelah menggunakan metode belajar gerakan dan lagu. Anak autis memerlukan metode belajar yang sesuai dengan minatnya.]
Association of the Apolipoprotein A-I gene polymorphisms with cardiovascular disease risk factors and atherogenic indices in patients from assam, Northeast India
Authors: Bora K , Pathak MS , Borah P , Hussain Md.I , Das D 
Published: September 2017

Abstract
Cardiovascular disease (CVD) risk factors, and particularly decreased high density lipoprotein cholesterol (HDL-C) dyslipidemia are prevalent in Assam, India. This study was undertaken to investigate whether Apolipoprotein A-I (APOA1) gene polymorphisms (G-75A and C+83T) were associated with i) the risk for decreased HDL-C, and ii) other CVD risk factors, viz. serum lipids, atherogenic indices, obesity, and blood pressure (BP). A total of 649 subjects were screened, from which 200 eligible individuals, classified as case group with decreased HDL-C levels (100 subjects) and control group with normal HDL-C levels (100 subjects) were enrolled and genotyped using polymersase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing. Lipid fractions [HDL-C, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), triglycerides (TG)] and atherogenic indices [Castelli’s Risk Indices-I and -II (CRI-I and -II), non-HDL-C fraction, atherogenic index of plasma (AIP), atherogenic coefficient (AC)] were estimated. The G-75A and C+83T loci were not associated with decreased HDL-C risk. This was confirmed across different genetic models (dominant, recessive, additive and allelic). Association was also absent with BP and obesity. However, the G-75A locus was associated with LDL-C, whereas the C+83T locus was associated with TG and VLDL-C. Furthermore, these sites had effects on atherogenic indices. The rare A allele at the G-75A locus was associated with adverse CRI-I, CRI-II, non-HDL-C and AC values, while the major C allele at the C+83T locus was associated with adverse AIP values. Thus, the pro-atherogenic G-75A polymorphism and the anti-atherogenic C+83T polymorphism represent important genetic loci that modulate CVD risk factors in subjects from Assam.
Analysis of the mitochondrial 4977 bp deletion in patients with hepatocellular carcinoma
Authors: Guo ZS , Jin CL , Yao ZJ , Wang YM , Xu BT 
Published: September 2017

Abstract
Mutations in the mitochondrial (mt) genome that result in mt dysfunction, have long been proposed to play important roles in the pathogenesis of hepatocellular carcinoma (HCC). Among these, the common mtDNA 4977 bp deletion is one of the most frequent mutations observed in various cancers. To understand the relationship between the mtDNA 4977 bp deletion and HCC, we performed mutational screening for the presence of this deletion in 105 HCC patients and 69 unrelated healthy subjects. After nested-polymerase chain reaction (nested-PCR) amplification, we found that there were 10 patients carrying the mtDNA 4977 bp deletion, and this deletion was absent in control subjects. Moreover, HCC patients carrying this deletion showed a marked increase in reactive oxygen species (ROS) level and mtDNA copy number when compared with the healthy controls. Taken together, our data indicated that the mtDNA 4977 bp deletion may play important role in the carcinogenesis of HCC, possibly via the alternation of mtDNA copy number and oxidative stress.
Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 gene on lipid profile and adipokines levels in obese subjects
Authors: Becer E , Çırakoğlu A 
Published: September 2017

Abstract
Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of metabolism, adipokines production and secretion. The aim of this study was to investigate the association between the PPARγ2 gene Pro12Ala polymorphism in obesity in terms of body mass index (BMI), lipid parameters, homeostasis model assessment of insulin resistance (HOMA-IR), serum lipid, leptin, adiponectin, resistin and chemerin levels. The study included 160 obese and 140 non obese subjects. The Pro12Ala polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum lipid, leptin, adiponectin, resistin and chemerin levels were measured. No association was found between the Pro12Ala polymorphism and BMI. Strikingly, in the study group, obese subjects with the AA genotype had significantly higher triglycerides (p = 0.046) and resistin (p <0.001) levels than those with the wild-type PP and heterozygous PA genotypes. Serum leptin and chemerin levels were significantly associated with Pro-12Ala poymorphism in the obese and non obese groups (p <0.01). In the obese group, subjects with the homozygous AA genotype had significantly lower adiponectin (p = 0.010) activity than the PP genotype. Our results suggest that the PPARγ2 gene Pro12Ala polymorphism has no direct association with obesity but does have significant influences on lipid profiles and adipokines levels.
Benign, pathogenic and copy number variations of unknown clinical significance in patients with congenital malformations and developmental delay
Authors: Mihaylova M , Staneva R , Toncheva D , Pancheva M , Hadjidekova S 
Published: September 2017

Abstract
The high frequency (3.0-5.0%) of congenital anomalies (CA) and intellectual disabilities (IDs), make them a serious problem, responsible for a high percentage (33.0%) of neonatal mortality. The genetic cause remains unclear in 40.0% of cases. Recently, molecular karyotyping has become the most powerful method for detection of pathogenic imbalances in patients with multiple CAs and IDs. This method is with high resolution and gives us the opportunity to investigate and identify candidate genes that could explain the genotype-phenotype correlations. This article describes the results from analysis of 81 patients with congenital malformations (CMs), developmental delay (DD) and ID, in which we utilized the CytoChip ISCA oligo microarray, 4 × 44 k, covering the whole genome with a resolution of 70 kb. In the selected group of patients with CAs, 280 copy number variations (CNVs) have been proven, 41 were pathogenic, 118 benign and 121 of unknown clinical significance (average number of variations 3.5). In six patients with established pathogenic variations, our data revealed eight pathogenic aberrations associated with the corresponding phenotype. The interpretation of the other CNVs was made on the basis of their frequency in the investigated group, the size of the variation, content of genes in the region and the type of the CNVs (deletion or duplication).
Inherited thrombophilias could influence the reproductive outcome in women with systemic lupus erythematosus
Authors: Robeva R , Tanev D , Andonova S , Nikolova M , Tomova A , Kumanov Ph , Savov A , Rashkov R , Kolarov Zl 
Published: September 2017

Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease associated with different reproductive complications in the affected women. Inherited thrombophilias are genetic factors increasing the risk for thromboembolism and recurrent pregnancy loss, but their influence on other reproductive disturbances in SLE patients has not been completely clarified. Two hundred and twenty-three Caucasian women (112 with SLE and 111 controls) were included in the study. Complete reproductive history of all SLE patients was carefully obtained. Genotyping for the FVLeiden, FIIG20210A, and MTHFRC677T polymorphisms was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis. No significant differences in the prevalence of the FVLeiden, FIIG20210A, and MTHFRC677T polymorphisms between patients and controls were established. Patients with FVLeiden had fewer pregnancies (0.57 ± 0.98 vs. 2.18 ± 1.58; p = 0.007) than the others, while no significant differences in the reproductive history of FIIG20210A carriers and non-carriers were observed (p >0.05). In the SLE group, 41.67% of women with the MTHFRC677T TT genotype had at least one miscarriage in comparison to only 14.00% of the other female patients (p = 0.030). While the prevalence of the investigated thrombophilias was similar in patients with SLE and healthy women, a substantial influence of the inherited prothrombotic factors on the reproductive history of patients was revealed. The investigations of the FVLeiden and MTHFRC677T polymorphisms in SLE patients could help to identify women at highest risk for reproductive failure and thus, further studies in other ethnic groups would be of strong clinical importance.
Familiarity in Chinese and English Idiom Comprehension: An Event Related Potential Study from Chinese English Learners
Authors: Haibo Shen , Yan Wang , Wenyu Liu 
Published: September 2017

Abstract
Idioms have attracted great attention over recent decades. Nevertheless, controversies still remain in regard of the most plausible cognition mechanism for idiom comprehension, especially concerning non-Indo-European languages and second/foreign language users. Event Related Potential (ERP) experiments on proficient English learners whose native language was Mandarin Chinese were conducted to test the influences of idioms’ familiarity on both Chinese and English (as foreign language) idiom comprehension. Data including accuracy rates, reaction time, and latency and peak amplitudes of N400 were recorded and analyzed, indicating that familiarity might play a significant role in idiom comprehension in both native and foreign languages. Further, idioms, should they have similar familiarity levels, may be easier to process in the native language (Chinese) than in the foreign language (English).
English Language Teaching in Iran: Tradition versus Modernity
Authors: Ekstam Jane M. , Sarvandy Elham 
Published: September 2017

Abstract
The present paper discusses the tension between tradition and modernity with respect to the teaching of English in Iran. It demonstrates that the second decade of the present century marks a shift, albeit nascent, in a) Iranian teachers and officials’ attitudes towards the content and method of English language teaching in terms of the need for greater interaction in the classroom, and b) raised awareness of the importance of culture in language teaching. We pose the question: “how can Iran continue to build on new ideas about English language teaching at school and tertiary levels with a view to improving not only pupils’/students’ performance but also embracing modernity in a globalized world?” The discussion is based on a survey of literature addressing the current state of English education in Iran.
The Influence of L2 on L1 Lexical Competence and Grammatical Properties in Written Expressions
Authors: Chunpeng Cai , Hee-Don Ahn 
Published: September 2017

AbstractThis article reports a study on the impact of L2 Korean on L1 Chinese lexical diversity and grammar in written expressions by Chinese bilinguals proficient in Korean. The statistical analysis showed that the cross-linguistic effects of L2 on L1 were significant although such impact was bidirectional. There were significantly more grammar errors and longer retrieval time committed by the bilingual group which implied negative L2 transfer to L1. Meanwhile, L2 also showed a positive influence on lexical diversity as there was no decline in lexical richness but an increase in lexical variations, and this indicated that L2-induced patterns did not replace or deteriorate L1 but instead added additional options to L1 expressions. This phenomenon can be characterized as the addition of new concepts and linguistic options to the already-existing L1 and conceptual repertoire. Specifically, meta-linguistic competence was enhanced. This research supports the theory of interference on L1 by the use of L2 (negative transfer), but it could also be enhanced by L2 (positive transfer).
A convenient regioselective synthesis of spirooxindolinopyrrolizidines incorporating the pyrene moiety through a [3 + 2]-cycloaddition reaction
Authors: Hussein Essam M. , Ahmed Saleh A. , Althagafi Ismail I. 
Published: September 2017

Abstract
A facile one-pot synthesis of spirooxindolinopyrrolizidines incorporating the pyrene moiety was accomplished in good yields through a 1,3-dipolar cycloaddition reaction of 3-aryl-1-(pyren-1-yl)prop-2-en-1-one derivatives with in situ-generated azomethine ylides.
Viszeraler Schmerz – eine biopsychologische Perspektive
Authors: Elsenbruch Sigrid , Icenhour Adriane , Enck Paul 
Published: September 2017

Zusammenfassung
Der von inneren Organen ausgehende, viszerale Schmerz unterscheidet sich in entscheidenden Aspekten von somatischen Schmerzen, sodass sich aus der somatischen Schmerzforschung gewonnene Erkenntnisse nur begrenzt übertragen lassen. Zugleich sind insbesondere zentralnervöse Mechanismen der bidirektionalen Kommunikation zwischen Darm und Gehirn bislang nur unzureichend verstanden. Diese Übersichtsarbeit beleuchtet den viszeralen Schmerz aus einer biopsychologischen Perspektive mit Schwerpunkt auf neurowissenschaftlichen Erkenntnissen. Die Bedeutung von Stress und weiteren psychologischen Einflussfaktoren auf die bidirektionale Signalvermittlung entlang der Gehirn-Darm-Achse steht dabei im Fokus. Zudem werden Befunde zu möglichen geschlechtsbezogenen Unterschieden bei viszeralen Schmerzen diskutiert. An der Schnittstelle von biologischer Psychologie, Neurogastroenterologie und den Neurowissenschaften soll so ein Einblick in ein faszinierendes, interdisziplinäres Forschungsgebiet eröffnet werden.
Voltage-gated sodium channels and pain
Authors: Nau Carla , Leipold Enrico 
Published: September 2017

Abstract
Painful stimuli are detected by specialized neurons, nociceptors, and are translated into action potentials, that are conducted along afferent pathways into the central nervous system, where they are conceived as pain. Voltage-gated sodium channels (NaV channels) are of paramount importance for nociceptor function, as they are responsible for the generation of action potentials and for their directed propagation. The exceptional role of sodium channel subtypes NaV1.7, NaV1.8 and NaV1.9 in the transmission of nociceptive signals has been emphasized by a variety of studies that associated genetically-induced malfunction of these channels with various pain diseases. In the following, structure and function of subtypes NaV1.7, NaV1.8 und NaV1.9 are briefly reviewed, associated pain diseases are introduced and current and future NaV-based strategies for the treatment of pain are discussed.
Visceral pain – a biopsychological perspective
Authors: Elsenbruch Sigrid , Icenhour Adriane , Enck Paul 
Published: September 2017

Abstract
Visceral pain arising from inner organs differs from somatic pain in crucial aspects, limiting the possibility to transfer knowledge derived from somatic pain research. The neurobiological mechanisms involved in the bidirectional communication between the brain and the gut along the brain-gut axis remain incompletely understood. This review addresses visceral pain from a biopsychological perspective, with an emphasis on psychological aspects and neuroimaging findings. It focuses on the role of stress and other psychological factors involved in the pathophysiology of chronic visceral pain in functional gastrointestinal disorders such as irritable bowel syndrome and summarizes findings on possible sex-related differences. Together, this overview aims to provide insights into a fascinating, interdisciplinary field of research at the interface between biological psychology, neurogastroenterology and the neurosciences.
Digitalisierung bei Genossenschaften
Authors: Peter Marc K. , Jungmeister Alexander 
Published: September 2017

Zusammenfassung
Das Thema Digitalisierung ist in Bezug auf Genossenschaften eine noch fast unerforschte, neue Problemstellung in der Genossenschaftswissenschaft, ist aber von hoher Relevanz für die Zukunft der Genossenschaften. Dieser Artikel führt in die Problematik ein, strukturiert sie und liefert dazu erste empirische Ergebnisse zum Stand der Digitalisierung bei Genossenschaften in der Schweiz. Methodisch wurde neben einer kurzen Literaturrecherche eine empirische Untersuchung bei den zwanzig größten Aktiengesellschaften und Genossenschaften in der Schweiz durchgeführt. Dabei zeigte sich, dass der Einsatz von ausgewählten Digitalisierungstechnologien bei Genossenschaften gegenüber Aktiengesellschaften noch ausbaufähig ist. Der wissenschaftliche Beitrag dieses Artikels liegt einerseits in der Strukturierung der Problematik, die sich spezifisch für Genossenschaften im Rahmen der Digitalisierung stellen, andererseits in ersten Befunden zur empirischen Realität des Einsatzes von Digitalisierungstechnologien sowie weitere Forschungsfragen zum Thema.
Estimation of Spatially Dependent Heat Flux Transients during Quenching of Inconel Probe in Molten Salt Bath
Authors: Pranesh Rao K. M. , Prabhu Narayan 
Published: September 2017

Abstract
Several industrial heat treatment processes, such as martempering and austempering, require a quench bath to be maintained at a temperature ranging between 150°C–600°C. Molten salts, molten alkali, and hot oils are the preferred quenchants for these processes. Molten salts and molten alkali are preferred over hot oil because they possess properties like wide operating temperature range, excellent thermal stability, and tolerance for contaminants. In the present work, the performance of a molten potassium nitrate (KNO3) quench bath was analyzed with an Inconel probe that measured 60 mm in height and 12.5 mm in diameter. The probe was heated to 850°C and subsequently quenched in a bath maintained at 450°C. Cooling curves at different locations of the probe were recorded using the K-type thermocouples inserted into the probe. Spatially dependent transient heat flux at the metal/quenchant interface was estimated using inverse heat conduction technique. The existence of two stages of quenching—boiling stage and convection stage—was confirmed by analyzing the heat flux. The heat transfer coefficient was calculated based on heat flux obtained by the inverse method. The nonuniformity in heat transfer along the length of the probe was quantified by calculating the range of surface temperatures at each instance. The hardness distribution in an AISI 4140 steel was predicted using the temperature distribution in the Inconel probe and obtained using inverse method. Uneven distribution of hardness predicted in the probe was attributed to the nonuniform cooling of the probe during quenching.