bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basidiobolomycosis – An Unsightly Devastating Condition, Ironically Responsive to Inexpensive Medications: A Case Report with Review of Literature
Authors: Kumar N. Naresh , Chelliah D. Suresh , Meganathan P. , Senguttuvan D. , Shyamsundar Skanda 
Published: September 2024

Background:
Basidiobolomycosis is an infection which results in an indolent, nonhealing, penetrating, unsightly destruction of subcutaneous tissues, rarely described in children.

Clinical Description:
A 6-year-old girl with no prior medical illness, presented with low-grade intermittent fever associated with an indurated swelling on the posterior aspect of her right leg, which gradually progressed over a period of 6 months into a deep, spreading, nonhealing ulcer, causing pain and restriction of movement.

Management and Outcome:
Routine blood investigations and swab cultures ruled out pyogenic infections and tuberculosis. She was negative for HIV. The wound was debrided, but there was poor response to antibiotics, fluconazole, and amphotericin B. Biopsy of debrided tissue revealed subcutaneous basidiobolomycosis. She was then treated with a combination of potassium iodide and cotrimoxazole. Over a 3-month period, the ulcer began granulating, and complete resolution was achieved through split-thickness skin grafting.

Conclusion:
Although uncommon, basidiobolomycosis may be considered in the evaluation of nonhealing penetrating ulcers, especially in immunocompetent children. Rather than expensive antifungals, potassium iodide and cotrimoxazole yield gratifying results in this condition.
Isolated Renal Hydatid Cysts in Children: A Systematic Review of Case Reports
Authors: Sharma Jignesh , Kulkarni Avani , Pathak Shrirang Deepak , Sharma Tanya , Kumar Amber , Malik Shikha , Bhatt Girish Chandra 
Published: September 2024

Background:Echinococcosis is a zoonotic tapeworm infection caused byEchinococcus granulosus,occasionally affecting humans. The larval infection most commonly affects the liver and lungs and very rarely the kidneys.Objective:The present systematic review compiles data regarding clinical presentations, diagnostic modalities, management strategies and recurrences in children with isolated renal hydatid cysts.Methods:A comprehensive search was done in major databases PubMed and Google Scholar using defined search terms encompassing case reports or case series on isolated renal hydatid cysts in children. The identified reports underwent screening by three different authors for inclusion and exclusion criteria.Results:The median (range) age at presentation of isolated renal hydatid disease was 10 (6) years with female preponderance (52.7%). Most common presenting symptom and sign were abdominal pain (64.8%) and palpable abdominal mass (56.7%), respectively. Ultrasonography (94.5%) was most common diagnostic method. Patients were primarily managed with surgical interventions (95.5%) and only 2/37 were managed solely by medical management for a median duration of 3.5 weeks. Laparoscopic cystectomy was the most commonly used surgical procedure (45.9%). Recurrence was observed to be rare, seen in only 3 cases.Conclusion:Hydatid cysts need to be considered in the differential diagnosis of renal cysts. Radiological evaluation with pathological confirmation enables diagnosis. Surgery combined with adjuvant anti-parasitic chemotherapy is used to treat the condition.
Bioinformatics and Chemoinformatics Analysis Explored the Role of Linum usitatissimum in Diabetic Heart Conditions: Experimental Analysis in H9c2 Rat Embryonic Cardiomyocytes Cell Lines
Authors: Safavi Kamran , Hajibabaie Fatemeh , Abedpoor Navid 
Published: September 2024

Abstract

Background:
Cytokine storms and inflammation lead to heart failure (HF). Bioactive compounds, as complementary medicine, can be the primary source of compounds with anti-inflammatory properties. Linum usitatissimum (LiU) has antioxidant capacity and anti-inflammatory activity. Here, candidate hugeness was selected based on the in silico studies, bio-cheminformatics, and bioinformatic analysis for excremental validation.

Methods:
We selected the vital genes with differential expression from the GSE26887 dataset. Based on the bioinformatics analysis, several parameters are determined to choose switchable genes involved in diabetic HF (DHF). We designed the protein–protein interactions network to consider the nodes’ degree, modularity, and betweenness centrality. Hence, we selected the interleukin (IL)-6 protein as a target for drug design and discovery to reduce diabetes complications in the heart. Here, H9c2 cell lines of rat embryonic cardiomyocytes induce HF using hyperglycemic and hyperlipidemic conditions. Real-time polymerase chain reaction evaluated the relative expression of SMAD7/NRF-2/STAT3. Furthermore, we assessed the concentration of IL-6 using the enzyme-linked immunosorbent assay technique.

Results:
Based on the bioinformatic analysis, we found that IL-6 with the highest network parameters score might be presented as a druggable protein in the DHF. Bioactive compounds and phytochemicals have potential strategies to manage DHF. LiUs decreased the expression level of the SMAD7 (P <0.0001) and STAT3 (P < 0.0001), and increased the expression level of the NRF2 (P < 0.0001). In addition, LiUs significantly reduced the concentration of IL-6 (P < 0.0001).

Conclusion:
Our data proposed that LiUs regulated inflammation and triggered the antioxidant defense in HF. Moreover, LiUs could have potential approaches to managing and preventing DHF.
Impact of Artificial Intelligence in Endodontics: Precision, Predictions, and Prospects
Authors: Parinitha M. S. , Doddawad Vidya Gowdappa , Kalgeri Sowmya Halasabalu , Gowda Samyuka S. , Patil Sahana 
Published: September 2024

Abstract
Artificial intelligence (AI) has become increasingly prevalent and significant across many industries, including the dental field. AI has shown accuracy and precision in detecting, evaluating, and predicting diseases. It can imitate human intelligence to carry out sophisticated predictions and decision-making in the health-care industry, especially in endodontics. AI models have demonstrated a wide range of applications in the field of endodontics. These include examining the anatomy of the root canal system, predicting the survival of dental pulp stem cells, gauging working lengths, identifying per apical lesions and root fractures, and predicting the outcome of retreatment treatments. Future uses of this technology were discussed in terms of robotic endodontic surgery, drug–drug interactions, patient care, scheduling, and prognostic diagnosis.
Diseases, drugs and dust
Authors: Tanomkiat Wiwatana 
Published: September 2024

From 1 January to 20 June 2024, there were 186,900 reported flu cases resulting in 14 deaths in various regions of Thailand and on 21 August 2024 Thailand confirmed the first case of a new lethal variant of mpox. Thailand's Ministry of Public Health has announced plans to reclassify cannabis and hemp as illegal narcotics starting 1 January 2025. Vaping bans were emphasized on 31 May, the World No Tobacco Day. The organized Lung Cancer Screening program was started in the Northern Thailand where the prevalence of lung cancer and the level of PM 2.5 were high.
ПОДКАСТ ЖӘНЕ ОНЫҢ ОҚЫТУ ТЕХНОЛОГИЯСЫ РЕТІНДЕ ТӘЖІРИБЕГЕ ЕНУ МӘСЕЛЕСІ
Authors: Әбілда Аяулым 
Published: September 2024

What technologies can we involve in the educational process? Our main goal is to use podcast technology as a didactic tool in Kazakh language classes based on innovative technologies in education. It's important for educators to integrate new technologies in the classroom. Among them, the podcast offers a range of potential benefits, including optimizing learning for language students. Therefore, this activity requires individual consideration as a learning technology. A podcast is a collection of short and long audio recordings that you can download and listen to online. This article discusses the application of podcast technology and ways of its effective use and construction in Kazakh language classes. Introducing such technologies in education will not only innovate technical tools in the classroom, but also expand teaching methodologies and educational processes
The relationship between hemoglobin to red cell distribution width (RDW) ratio (HRR) and prognosis in patients with acute coronary syndrome
Authors: Eyiol Azmi , Ertekin Birsen 
Published: September 2024

Aims: The use of hematological parameters in the prognostic assessment of acute coronary syndrome (ACS) has become common in recent years. Thus, our study aimed to evaluate the relationship between hemoglobin to red cell distribution width (RDW) ratio (HRR) and prognosis of these patients.
Methods: A retrospective evaluation was conducted on patients who presented to the emergency department between 01.09.2023 and 01.04.2024 and received a diagnosis of ACS. HRR was determined by dividing the hemoglobin concentration by the red cell distribution width (RDW). The patients were categorized into two groups based on their HRR values: high HRR patients and low HRR patients, using a specified HRR cut-off value. Statistical comparisons were conducted on all parameters between the two patient groups. The variables potentially linked to mortality were analyzed using receiver operating characteristic (ROC) analysis.
Results: The in-hospital mortality rate, vasopressor needs, and MV support requirements were significantly higher in the low HRR (≤0.828) group than in the high HRR (>0.828) group (p
Studi Komparasi Pengaruh Online Rating Dan Online Review Terhadap Keputusan Pembelian Konsumen Pada Online Marketplace (Shopee Dan Tokopedia)
Authors: Rakhmawati Ita , Tari Selviana 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui perbedaan pengaruh online rating dan online review terhadap keputusan pembelian konsumen. Penelitian ini merupakan jenis penelitian komparatif menggunakan pendekatan penelitian kuantitatif. Obyek penelitian ini adalah marketplace Shopee dan Tokopedia. Penelitian ini menggunakan metode pengumpulan data yaitu kuesioner online dengan google form yang disebar kepada mahasiswa aktif program studi Manajemen Bisnis Syariah IAIN Kudus melalui media sosial. Sedangkan teknik pengambilan sampel menggunakan teknik proportionate stratified random sampling karena populasi mempunyai anggota atau unsur yang tidak homogen atau berstrata secara proporsional. Hasil penelitian ini menunjukkan secara signifikan terdapat pengaruh positif online rating (X1) dan online review (X2) dengan keputusan pembelian konsumen pada marketplace Shopee dan marketplace Tokopedia. Kemudian dilihat dari nilai R Square pada marketplace Shopee sebesar 0.416 yang berarti 41,6% variabel keputusan pembelian (Y) dapat dijelaskan variabel independen yaitu online rating (X1) dan online review (X2). Nilai R Square pada marketplace Tokopedia sebesar 0.397 yang berarti 39,7% variabel keputusan pembelian (Y) dapat dijelaskan variabel independen yaitu online rating (X1) dan online review (X2). Hasil uji beda penelitian ini menunjukkan tidak terdapat perbedaan yang signifikan pengaruh online rating terhadap keputusan pembelian konsumen pada marketplace Shopee dan marketplace Tokopedia. Sedangkan pada variabel online review terdapat perbedaan online review terhadap keputusan pembelian konsumen pada marketplace Shopee dan Tokopedia
Pendekatan Konseling Realitas Dalam Mengatasi Sibling Rivalry Anak Usia Dini
Authors: Alivia Zahra  , Ati Kusmawati  , Fitria Anggraheni Subagio  , Maulana Nadzif Fanany Putra Hanafi   
Published: September 2024

This article aims to determine the sibling rivalry in early childhood in the concept of a reality counseling approach and theresults of previous relevant research on sibling rivalry. Sibling rivalry is a form of competition between sibling,between brothers and sisters to win the attention and affection of parents. Every child has a unique personality and has different needs. This literature review discusses sibling rivalry behavior that occurs in early childhood in the concept of theory and reality counseling. This research employed descriptive qualitative method using a literature review. The results of this research ofl iterature indicate that thea pplication of reality counseling can reduce sibling rivalry behavior in early childhood
Pengaruh Pendekatan Eksplorasi Lingkungan Terhadap Pengetahuan Sains Anak Usia Dini di Raudhatul Athfal Ar Rahmah Medan
Authors: Maysarah Rabiul Aulia Damanik  , Humaidah Br. Hasibuan  , Raisah Armayanti Nasution  
Published: September 2024

This research was carried out at Raudhatul Atfal RA Ar Rahmah Medan. The type of this study is a quantitative experiment with a Quasi Experimental Design with a Non-Equivalent Control Group Design. The population of this study is 26 children, so because the population is less than 100, the sample determination uses random sampling techniques. The formulation of this research problem: How is early childhood science knowledge in RA Ar Rahmah, and is there an effect of the application of the environmental exploration approach on early childhood science knowledge at RA Ar Rahmah. This study aims to find out: (1) early childhood science knowledge in RA Ar Rahmah (2) the influence of the application of the environmental exploration approach on early childhood science knowledge at RA Ar Rahmah. From the results of the study, there was an average score of 53.84 for the pre-test experimental class and an average of 70 for the post-test, with the highest score of 80 for the post test and the lowest score for the 60 post-test. The control class with an average pre-test score of 47.30 and an average post test score of 68.84, with the highest score of 80 and the lowest score of 60. The results of the hypothesis test were obtained > ttable, which was 0.20 > 1.71387 with a significant number of α= 0.05. Thus, Ho's hypothesis was rejected and Ha accepted so that it can be stated that there is a significant influence between the application of environmental exploration to early childhood science knowledge at RA Ar Rahmah Medan Estate, Percut Sei Tuan District, Medan City T.A 2023/2024.

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Anatomical and subcortical invasiveness in diffuse low-grade astrocytomas differ between IDH status and provide prognostic information
Authors: Zetterling Maria , Fahlström Markus , Latini Francesco 
Published: September 2024

Background: Diffuse astrocytomas preferentially infiltrate eloquent areas affecting the outcome. A preoperative understanding of isocitrate dehydrogenase (IDH) status may offer opportunities for specific targeted therapies impacting treatment management. The aim of this study was to analyze clinical, topographical, radiological in WHO 2 astrocytomas with different IDH status and the long-term patient’s outcome.
Methods: A series of confirmed WHO 2 astrocytoma patients (between 2005 and 2015) were retrospectively analyzed. MRI sequences (FLAIR) were used for tumor volume segmentation and to create a frequency map of their locations into the Montreal Neurological Institute (MNI) space. The Brain-Grid (BG) system (standardized radiological tool of intersected lines according to anatomical landmarks) was used as an overlay for infiltration analysis of each tumor. Long-term follow-up was used to perform a survival analysis.
Results: Forty patients with confirmed IDH status (26 IDH-mutant, IDHm/14 IDH-wild type, IDHwt) according to WHO 2021 classification were included with a mean follow-up of 7.8 years. IDHm astrocytomas displayed a lower number of BG-voxels (P < 0.05) and were preferentially located in the anterior insular region. IDHwt group displayed a posterior insular and peritrigonal location. IDHwt group displayed a shorter OS compared with IDHm (P < 0.05), with the infiltration of 7 or more BG-voxels as an independent factor predicting a shorter OS.
Conclusions: IDHm and IDHwt astrocytomas differed in preferential location, number of BG-voxels and OS at long follow-up time. The number of BG-voxels affected the OS in IDHwt was possibly reflecting higher tumor invasiveness. We encourage the systematic use of alternative observational tools, such as gradient maps and the Brain-Grid analysis, to better detect differences of tumor invasiveness in diffuse low-grade gliomas subtypes.
A Closer Look at Race, Ethnicity, and Gender Neutral Models
Authors: Cahill Kevin E. , Spizman Lawrence M. 
Published: September 2024

Abstract
Litigation cases involving the expected earnings of minor children provide an ideal environment to examine the implications of public policies that attempt to mitigate racial, ethnic, and gender discrimination in the calculation of economic damages. This paper extends the existing literature on the implications of race, ethnicity, and gender neutral models by evaluating both educational attainment probabilities and estimated lifetime earnings within educational attainment categories. Recent related studies have focused on the educational attainment portion of the calculation only. We perform thousands of simulations of a child’s lifetime earnings using neutral estimations—a proxy for removing discrimination—and compare those estimates to ones in which race, ethnicity, and gender are taken into account. We find wide variation within racial and ethnic groups when earnings are incorporated into the analysis, consistent with prior research. Importantly, however, our findings pertain primarily to females, suggesting that interactions between gender and race and ethnicity are an added complexity. The practical implication of our findings is that neutral models can adversely impact individual members of protected groups. The results provide further guidance to policymakers who might be interested in the real-world outcomes associated with legislation that restricts how economists calculate economic damages.
ОРУСИЯ ИМПЕРИЯСЫНЫН ТҮРКСТАНДАГЫ “МУСУЛМАНЧЫЛЫК МАСЕЛЕСИНЕ” КАРАТА МАМИЛЕСИ
Authors: Авазов Эрнис Абдыманапович 
Published: September 2024

Макалада Россия империясынын мамлекеттик-конфессиялык саясатынын маанилүү аспектилеринин бири катары "мусулманчылык маселесинин" калыптануу жана өнүгүү тарыхына сереп салынды. Аталган мамиленин алкагында Кафумандын “Исламга этабар бербөө” башкаруу курсунун маанисин жана анын ордун ачып берүүгө аракеттер жасалды. Падыша өкмөтүнун империянын мусулман калктарына карата саясаты көп жактуу болгондугу ачып берилди. Мындай саясат отурукташкан жана көчмөн калктын мусулмандык жана диний фанатизм деңгээлине жараша жүргөндүгү белгиленди. Элдик көтөрүлүштөрдүн жыйынтыгында дин саясатын, мусулманчылыкка карата кайра карап чыгуу аракеттери бир нече жолу болгондугу ачылып берилди. Автор падышачылыктын диний көтөрүмдүүлүк принцибине негизделген Түркстандагы мусулмандарга карата саясаты мусулман калкына динди таңуулоого жана ачык диний басмырлоону ишке ашырууга жол койбогон деген тыянакка келген.
КӨРКӨМ ӨНӨР САБАКТАРЫН УЮШТУРУУНУН МАКСАТТАРЫ, ШАРТТАРЫ, МЕТОДДОРУ ЖАНА ПРИНЦИПТЕРИ ЖӨНҮНДӨ
Authors: Ысмайылов Муктар Зулпукарович , Мамазаиров Мирлан Латипович , Эсенбай уулу Баястан 
Published: September 2024

Макала көркөм өнөр сабактарын окутуунун айрым методикалык маселелерине арналган. Окутуу процесстерин уюштуруунун негизги компоненттери анализделди. Көркөм өнөр сабактарынын мазмунун, максаттарын жана милдеттерин аныктоодо мугалим негизинен эмнелерди даана билүүгө тийиш деген суроолордун айланасындагы маселелер каралды. Мындан сырткары сабактын натыйжалуулугун анын баланын инсандык сапаттарынын калыптанышындагы өзгөрүүлөрдү аныктоо, аларды баалоо сыяктуу жагдайларга көңүл бурулду.
Hemerobia da paisagem na perspectiva ecossociossistêmica na bacia hidrográfica do rio Turvo, Barra do Turvo/SP
Authors: Da Costa Rodrigues Luciene , Alves da Silva Neves Sandra Mara , Souza Lima José Edmilson 
Published: September 2024

As transformações antrópicas desencadeadas, em parte, pelos seres humanos têm provocado o desequilíbrio dos padrões e processos ecológicos nas bacias hidrográficas ao longo dos anos e, consequentemente, a instabilidade da paisagem. Nesse contexto, a Hemerobia avalia a intensidade das alterações na estrutura e na função da paisagem e as classifica conforme seu grau de naturalidade. Com isso, este estudo tem como objetivo analisar a paisagem da Bacia Hidrográfica do Rio Turvo no município de Barra do Turvo/SP de acordo com os Graus de Hemerobia. Os arquivos vetoriais de cobertura vegetal e os usos da terra nos anos de 1990, 2000, 2010 e 2020 foram combinados, por meio da ferramenta Intersect do ArcGIS, com os arquivos vetoriais de pedologia, geologia, geomorfologia, amplitude do relevo, declividade, clima e erodibilidade. Após a combinação dos arquivos, os Graus de Hemerobia foram classificados para que os mapas fossem gerados. Os resultados dos Graus de Hemerobia na bacia investigada correspondeu desde Mínimo (compreendendo as classes florestais e água) com baixa dependência tecnológica e energética para a manutenção das funções ecológicas a Muito alto (abrange a área urbana de Barra do Turvo/SP) com alta dependência tecnológica e energética e baixa capacidade de autorregulação. A paisagem da bacia investigada apresenta grau alto de intervenção humana causada pela prática da atividade agropecuária, consequente vegetação secundária e influência urbana. Portanto, o estudo da Hemerobia é importante para avaliar os impactos negativos no ecossistema local, colaborando para a construção do planejamento da paisagem e para as tomadas de decisão em nível municipal, estadual e nacional.
Analisis Pending Klaim BPJS Kesehatan Pasien Rawat Inap Di Rumah Sakit Islam Jakarta Pondok Kopi Tahun 2023
Authors: Sri Mulya  , Dina Sonia  , Daniel Happy Putra  , Noor Yulia  
Published: September 2024

Pending BPJS Health claims at RSIJ Pondok Kopi are divided into 3 (three) aspects including administration, coding and medical. This research aims to determine the factors of causes pending claims, resolution, and pending trends using a descriptive quantitative approach, which provides an overview of the factors causing pending claims and pending trends in 2023. Results with 1,143 samples of pending claim reports due to administration 523 (46%) with the most pending categories due to inappropriate treatment class 120 (23%), causative factors due to coding 570 (50%) with the most pending categories due to inaccurate diagnosis 525 (92.1%), and factors medical causes 50 (4%) with the most pending category due to inappropriate medical indications 36 (72%). So the pending settlement is carried out after receiving the verification results report by the casemix officer by completing the claim requirements according to the pending claim category and confirming with the DPJP if necessary. The pending trend in 2023 for 1st semester period January to June showed decreasing results with a significant decrease in March of 12%. To minimize pending figures, hospitals should recruit employees according to their field of competence, empower existing human resources by clinical coding training, implement RME so that RM documentation is more complete, and internal verification officers are more thorough in carrying out their work.