bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybridization of MOFs and COFs: A New Strategy for Construction of MOF@COF Core–Shell Hybrid Materials
Authors: Peng Yongwu , Zhao Meiting , Chen Bo , Zhang Zhicheng , Huang Ying , Dai Fangna , Lai Zhuangchai , Cui Xiaoya , Tan Chaoliang , Zhang Hua 
Published: November 2017

AbstractThe exploration of new porous hybrid materials is of great importance because of their unique properties and promising applications in separation of materials, catalysis, etc. Herein, for the first time, by integration of metal–organic frameworks (MOFs) and covalent organic frameworks (COFs), a new type of MOF@COF core–shell hybrid material, i.e., NH2‐MIL‐68@TPA‐COF, with high crystallinity and hierarchical pore structure, is synthesized. As a proof‐of‐concept application, the obtained NH2‐MIL‐68@TPA‐COF hybrid material is used as an effective visible‐light‐driven photocatalyst for the degradation of rhodamine B. The synthetic strategy in this study opens up a new avenue for the construction of other MOF–COF hybrid materials, which could have various promising applications.
A phase II trial of ruxolitinib in combination with azacytidine in myelodysplastic syndrome/myeloproliferative neoplasms
Authors: Assi Rita , Kantarjian Hagop M. , Garcia‐Manero Guillermo , Cortes Jorge E. , Pemmaraju Naveen , Wang Xuemei , Nogueras‐Gonzalez Graciela , Jabbour Elias , Bose Prithviraj , Kadia Tapan , Dinardo Courtney D. , Patel Keyur , Bueso‐Ramos Carlos , Zhou Lingsha , Pierce Sherry , Gergis Romany , Tuttle Carla , Borthakur Gautam , Estrov Zeev , Luthra Rajyalakshmi , Hidalgo‐Lopez Juliana , Verstovsek Srdan , Daver Naval 
Published: November 2017

AbstractRuxolitinib and azacytidine target distinct disease manifestations of myelodysplastic syndrome/myeloproliferative neoplasms (MDS/MPNs). Patients with MDS/MPNs initially received ruxolitinib BID (doses based on platelets count), continuously in 28‐day cycles for the first 3 cycles. Azacytidine 25 mg/m2 (Day 1‐5) intravenously or subcutaneously was recommended to be added to each cycle starting cycle 4 and could be increased to 75 mg/m2 (Days 1‐5) for disease control. Azacytidine could be started earlier than cycle 4 and/or at higher dose in patients with rapidly proliferative disease or with elevated blasts. Thirty‐five patients were treated (MDS/MPN‐U, n =14; CMML, n =17; aCML, n =4), with a median follow‐up of 15.2 months (range, 1.0–41.5). All patients were evaluable by the 2015 international consortium proposal of response criteria for MDS/MPNs (ICP MDS/MPN) and 20 (57%) responded. Nine patients (45%) responded after the addition of azacytidine. A greater than 50% reduction in palpable splenomegaly at 24 weeks was noted in 9/14 (64%) patients. Responders more frequently were JAK2‐mutated (P = .02) and had splenomegaly (P = .03) compared to nonresponders. New onset grade 3/4 anemia and thrombocytopenia occurred in 18 (51%) and 19 (54%) patients, respectively, but required therapy discontinuation in only 1 (3%) patient. Patients with MDS/MPN‐U had better median survival compared to CMML and aCML (26.5 vs 15.1 vs 8 months; P = .034). The combination of ruxolitinib and azacytidine was well‐tolerated with an ICP MDS/MPN‐response rate of 57% in patients with MDS/MPNs. The survival benefit was most prominent in patients with MDS/MPN‐U.
Crochelins: Siderophores with an Unprecedented Iron‐Chelating Moiety from the Nitrogen‐Fixing Bacterium Azotobacter chroococcum
Authors: Baars Oliver , Zhang Xinning , Gibson Marcus I. , Stone Alan T. , Morel François M. M. , Seyedsayamdost Mohammad R. 
Published: November 2017

AbstractMicrobes use siderophores to access essential iron resources in the environment. Over 500 siderophores are known, but they utilize a small set of common moieties to bind iron. Azotobacter chroococcum expresses iron‐rich nitrogenases, with which it reduces N2. Though an important agricultural inoculant, the structures of its iron‐binding molecules remain unknown. Here, the “chelome” of A. chroococcum is examined using small molecule discovery and bioinformatics. The bacterium produces vibrioferrin and amphibactins as well as a novel family of siderophores, the crochelins. Detailed characterization shows that the most abundant member, crochelin A, binds iron in a hexadentate fashion using a new iron‐chelating γ‐amino acid. Insights into the biosynthesis of crochelins and the mechanism by which iron may be removed upon import of the holo‐siderophore are presented. This work expands the repertoire of iron‐chelating moieties in microbial siderophores.
One‐Pot Synthesis of Contracted and Expanded Porphyrins with meso‐CF3 Groups
Authors: Chen Qiu‐Cheng , Soll Matan , Mizrahi Amir , Saltsman Irena , Fridman Natalia , Saphier Magal , Gross Zeev 
Published: November 2017

AbstractCorrole and sapphyrin with the smallest meso‐substituents reported so far were prepared in a one‐pot synthesis that relies on a non‐aldehydic precursor for introducing CF3 groups. The substantial amounts of products obtained by this facile pathway allowed for the full characterization of 5,10,15‐tris(trifluoromethyl)corrole, the access to a variety of stable chelates thereof and investigations that disclose the unique structural and chemical properties induced by the CF3 substituents. The novel 5,10,15,20‐tetra(trifluoromethyl)sapphyrin undergoes only single protonation, which according to its crystal structure is stabilized by favorable non‐bonding F/H interaction between the meso‐CF3 and the inverted pyrrolic NH.
Oxime Ether Radical Cations Stabilized by N‐Heterocyclic Carbenes
Authors: Kim Youngsuk , Kim Kimoon , Lee Eunsung 
Published: November 2017

AbstractN‐heterocyclic carbene (NHC) nitric oxide (NHCNO) radicals, which can be regarded as iminoxyl radicals stabilized by NHCs, were found to react with a series of silyl and alkyl triflates to generate the corresponding oxime ether radical cations. The structures of the resulting oxime ether radical cations were determined by X‐ray crystallography, along with EPR and computational analysis. In contrast, lutidinium triflate produced a 1:1 mixture of [NHCNO+][OTf−] and [NHCNHOH+][OTf−] upon the reaction with NHCNO. This study adds an important example of stable singlet carbenes for stabilizing main‐group radicals because of their π‐conjugating effect, the synthesis and structures of which have not been reported previously.
Conductive Microporous Covalent Triazine‐Based Framework for High‐Performance Electrochemical Capacitive Energy Storage
Authors: Li Yajuan , Zheng Shuanghao , Liu Xue , Li Pan , Sun Lei , Yang Ruixia , Wang Sen , Wu Zhong‐Shuai , Bao Xinhe , Deng Wei‐Qiao 
Published: November 2017

AbstractNitrogen‐enriched porous nanocarbon, graphene, and conductive polymers attract increasing attention for application in supercapacitors. However, electrode materials with a large specific surface area (SSA) and a high nitrogen doping concentration, which is needed for excellent supercapacitors, has not been achieved thus far. Herein, we developed a class of tetracyanoquinodimethane‐derived conductive microporous covalent triazine‐based frameworks (TCNQ‐CTFs) with both high nitrogen content (>8 %) and large SSA (>3600 m2 g−1). These CTFs exhibited excellent specific capacitances with the highest value exceeding 380 F g−1, considerable energy density of 42.8 Wh kg−1, and remarkable cycling stability without any capacitance degradation after 10 000 cycles. This class of CTFs should hold a great potential as high‐performance electrode material for electrochemical energy‐storage systems.
Gas‐permeation performance of metal organic framework/polyimide mixed‐matrix membranes and additional explanation from the particle size angle
Authors: Duan Cuijia , Jie Xingming , Zhu Haitao , Liu Dandan , Peng Weiming , Cao Yiming 
Published: November 2017

ABSTRACTWith MOFs of Cu3(BTC)2 and ZIF‐8 as the dispersed phases and four polyimides with CO2 permeabilities ranging from 1.36 to 564 barrer as the continuous phase, the influence of metal organic frameworks on the gas‐separation properties of mixed‐matrix membranes (MMMs) was investigated. The results show that the gas permeabilities of all of the prepared MMMs greatly increased and even largely exceeded the predicted value of the Bruggeman model; for example, with the same Cu3(BTC)2 loading of 21.3 vol %, the O2 permeability increase rate of our prepared Cu3(BTC)2/Matrimide 5218‐20 MMMs was 2.26 times, whereas that predicted by the Bruggeman model was only 1.05 times. In addition, when the gas permeability of the polymeric phase was far lower than the dispersed phase of ZIF‐8 or Cu3(BTC)2 compared with ZIF‐8, which had a particle size (R) around 150 nm, Cu3(BTC)2 of 5–15 µm showed a little better enhancing effect on the gas‐permeation performance of the MMMs. In addition to the properties of the dispersed and continuous phases, we speculated that the ratio between R of the dispersed phase to the membrane thickness (L) played an important role for MMMs; the larger R/L was, the greater the gas permeability of the MMMs was. This speculation was initially evidenced by the ZIF‐8/ODPA/TMPDA‐20 MMMs with different Ls. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45728.
Effect of the structural characteristics of solution styrene–butadiene rubber on the properties of rubber composites
Authors: Hou Guanyi , Tao Wei , Liu Jun , Zhang Xiaoyue , Dong Mengjie , Zhang Liqun 
Published: November 2017

ABSTRACTSolution‐polymerized styrene–butadiene rubber (SSBR) has been widely used in the high‐quality tire industry, and various brands of SSBR have been synthesized. Five kinds of SSBR were selected from multiple products to investigate the effects of different brands of SSBR on the comprehensive properties. Different characterization tools, such as Fourier transform infrared spectroscopy, 1H‐NMR, and differential scanning calorimetry, were used to characterize the microstructures of the SSBRs. The results show that the microstructures of the SSBRs distinctly affected the comprehensive properties of the SSBR composites, especially the properties of the “magic triangle.” For instance, the content of trans‐1,4‐butadiene positively corresponded to the Akron abrasion for the SSBR composites with different brands, and cis‐1,4‐butadiene could partly replace the influence of vinyl when the content of trans‐1,4‐butadiene was small. SSBR 2564S, SSBR 4526‐2, and SSBR 2535E were selected because of the excellent magic‐triangle properties. They were used to investigate the effects of different brands of SSBR with different ratios of natural rubber (NR) to SSBR on the comprehensive properties of the NR–SSBR rubber blend composites. The results indicate that the properties of magic triangle were distinctly enhanced. However, there was an optimized content of SSBR to enhance the wear resistance (≤15 phr). For SSBR 4526‐2, the Payne effect was negatively correlated to the content of SSBR, whereas for SSBR 2564S and SSBR 2535E, the Payne effect was positively correlated to the content of SSBR. On the basis of these results, the SSBR 2564S seemed to exhibit the best comprehensive properties to prepare a tire tread tailored for high‐performance tires. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45749.
Effect of interface and confinement size on the crystallization behavior of PLLA confined in coaxial electrospun fibers
Authors: Zou Shu‐Fen , Wang Rui‐Yang , Fan Bin , Xu Jun‐Ting , Fan Zhi‐Qiang 
Published: November 2017

ABSTRACTPoly(l‐lactide)/polyacrylonitrile (PLLA/PAN) core‐sheath composite fibers were fabricated by coaxial electrospinning. The crystallization behavior of PLLA within the coaxial electrospun fibers was studied by differential scanning calorimetry (DSC). The PLLA/PAN coaxial electrospun fiber with a PLLA diameter of ∼32 nm (C1) exhibits a crystallization temperature (Tc) of 22.5 °C higher but a cold‐crystallization temperature (Tcc) of 10 °C lower than bulk PLLA. The crystallinity of C1 fiber is also higher than bulk PLLA. In both isothermal melt‐ and cold‐crystallization, PLLA in C1 fiber crystallizes faster than the bulk PLLA, as revealed by the smaller half crystallization times (t1/2). The enhanced crystallizability of PLLA in the C1 fiber may be attributed to the increased nuclei number and crystal growth rate induced by the PAN surface, i.e., surface‐induction effect. However, PLLA also suffers a nano‐confinement effect exerted by PAN sheath in the coaxial electrospun fiber, which can suppress PLLA crystallization. When the diameter of PLLA is too small (< 32 nm), the nano‐confinement effect may prevail over the surface‐induction effect, leading to a slower crystallization rate and smaller crystallinity. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45980.
Robust Double‐integral T‐S Fuzzy Output Regulation for Nonlinear Systems
Authors: Lian Kuang‐Yow , Liu Chien‐Hung , Chiu Chian‐Song 
Published: November 2017

AbstractThis paper proposes a robust double‐integral T‐S fuzzy output regulator design for affine nonlinear systems in the presence of parametric uncertainty and external disturbance. First, we adopt double integrators (an error integrator and an input integrator) to obtain an augmented T‐S fuzzy model representation which has a common input matrix of fuzzy rules. This property yields less stability conditions. Next, by introducing a set of virtual desired variables (VDVs), a double‐integral VDV‐based fuzzy regulator is proposed to cope with unknown bias and to achieve asymptotical output regulation. Afterward, the controller is simplified to avoid VDV calculation and enhance robustness to uncertainty and external disturbance. In contrast to traditional regulation design, the double‐integral non‐VDV fuzzy regulator design reduces the number of fuzzy controller rules and stability LMIs. Moreover, the error coordinate transformation is removed and the uncertainty is allowed in this paper. Finally, a DC/DC buck converter system is taken as the example to demonstrate the expected performance.
Clinical and molecular genetic characterization of a male patient with Sensenbrenner syndrome (cranioectodermal dysplasia) and biallelic WDR35 mutations
Authors: Walczak‐Sztulpa Joanna , Wawrocka Anna , Swiader‐Lesniak Anna , Socha Magdalena , Jamsheer Aleksander , Drozdz Dorota , Latos‐Bielenska Anna , Zachwieja Katarzyna 
Published: November 2017

BackgroundSensenbrenner syndrome (cranioectodermal dysplasia, CED) is a very rare autosomal recessive ciliopathy first described by Judith Sensenbrenner in 1975. CED is a complex disorder characterized by craniofacial, skeletal, and ectodermal abnormalities. The clinical symptoms are variable and the CED phenotype may present intrafamilial and interfamilial differences. Sensenbrenner syndrome belongs to a group of ciliary chondrodysplasias and is a genetically heterogeneous disease. Mutations in six genes: IFT122, WDR35, IFT43, WDR19, IFT52, and IFT140 have been associated with this disorder. All known CED genes encode proteins that are part of the intraflagellar transport complex, which plays an important role in the assembly and maintenance of cilia.CaseWe report a on 2‐year‐old male patient affected by Sensenbrenner syndrome. Dysmorphic features included short stature with rhizomelic shortening of limbs, short fingers, narrow chest, high forehead, epicanthal folds, telecanthus, broad nasal bridge, low‐set ears, sparse hair, and widely space teeth. Craniosynostosis was surgically corrected at the age of 4 months. The patient presented chronic renal disease. Nephrologic picture showed early stages of nephronophthisis. Psychomotor development was apparently normal. Molecular analysis of the affected individual revealed compound heterozygosity for a novel nonsense p.(Arg113*) and a missense p.(Asp841Val) variant in the WDR35 gene.ConclusionsThe observations of the CED patient in this study provide additional clinical data and expand the molecular spectrum of Sensenbrenner syndrome. Moreover, the two variants identified in the proband provide further evidence for the WDR35 mutations as the most common cause of this rare syndrome.
A fast and simple method to estimate relative, hyphal tensile‐strength of filamentous fungi used to assess the effect of autophagy
Authors: Quintanilla Daniela , Chelius Cynthia , Iambamrung Sirasa , Nelson Sidney , Thomas Donnel , Gernaey Krist V. , Marten Mark R. 
Published: November 2017

AbstractFungal hyphal strength is an important phenotype which can have a profound impact on bioprocess behavior. Until now, there is not an efficient method which allows its characterization. Currently available methods are very time consuming, thus, compromising their applicability in strain selection and process development. To overcome this issue, a method for fast and easy, statistically verified quantification of relative hyphal tensile strength was developed. It involves off‐line fragmentation in a high shear mixer followed by quantification of fragment size using laser diffraction. Particle size distribution (PSD) is determined, with analysis time on the order of minutes. Plots of PSD 90th percentile versus time allow estimation of the specific fragmentation rate. This novel method is demonstrated by estimating relative hyphal strength during growth in control conditions and rapamycin‐induced autophagy for Aspergillus nidulans (parental strain) and a mutant strain (ΔAnatg8) lacking an important autophagy gene. Both strains were grown in shake flasks and relative hyphal tensile strength was compared. The mutant strain grown in control conditions appears to be weaker than the parental strain, suggesting that Anatg8 may play a role in other processes involving cell wall biosynthesis. Furthermore, rapamycin‐induced autophagy resulted in apparently weaker cells even for the mutant strain. These findings confirm the utility of the developed method in strain selection and process development.
Analytical approach, dissipation pattern and risk assessment of pesticide residue in green leafy vegetables: A comprehensive review
Authors: Farha Waziha , Abd El‐Aty A. M. , Rahman Md. Musfiqur , Jeong Ji Hoon , Shin Ho‐Chul , Wang Jing , Shin Sung Shik , Shim Jae‐Han 
Published: November 2017

AbstractThe category of ‘leafy vegetables’ comprises a wide range of plants, including cabbage, lettuce, leeks, spinach, Swiss chard and kale, and it forms a significant component of the human diet. Typically, leafy vegetables are low in calories and fat, are great sources of vitamins, protein, dietary fibre and minerals (including iron, calcium, and nitrates), and are rich in phytochemicals. To counter the impact of pests on vegetables, a broad variety of pesticides are used. Because of their large surface areas, leafy vegetables are expected to have high residual pesticide levels. As such, a sound analytical approach is needed to detect and quantify residue levels that are equal to or lower than the maximum residue limits, thus rendering the products safe for consumption. Overall, leafy vegetables consumed raw (after a tap water wash only), boiled or steamed contribute 2% of total vegetable consumption globally, and they might have a comparatively greater influence on health than cereal ingestion. Consequently, in this review paper, we highlight the importance of leafy vegetables, the pesticides that are commonly used on them and various analytical techniques, including sample preparation, extraction, clean‐up and final detection. The effects on dissipation patterns, pre‐harvest residue limits and safety/risks imposed by various pesticides are also reviewed and discussed. In conclusion, environmentally friendly extraction methods coupled with high‐throughput techniques with greater reproducibility and lower uncertainty are needed for quantifying residues in leafy vegetables at very low concentrations. Commercial and household food preparation, such as washing, peeling, blanching and cooking are effective in removing most of the pesticide residues that are loosely attached on vegetables.
A novel fast method for aqueous derivatization of THC, OH‐THC and THC‐COOH in human whole blood and urine samples for routine forensic analyses
Authors: Stefanelli Fabio , Pesci Federica Giorgia , Giusiani Mario , Chericoni Silvio 
Published: November 2017

AbstractA novel aqueous in situ derivatization procedure with propyl chloroformate (PCF) for the simultaneous, quantitative analysis of Δ9‐tetrahydrocannabinol (THC), 11‐hydroxy‐Δ9‐tetrahydrocannabinol (OH‐THC) and 11‐nor‐Δ9‐tetrahydrocannabinol‐carboxylic acid (THC‐COOH) in human blood and urine is proposed. Unlike current methods based on the silylating agent [N,O‐bis(trimethylsilyl)trifluoroacetamide] added in an anhydrous environment, this new proposed method allows the addition of the derivatizing agent (propyl chloroformate, PCF) directly to the deproteinized blood and recovery of the derivatives by liquid–liquid extraction. This novel method can be also used for hydrolyzed urine samples. It is faster than the traditional method involving a derivatization with trimethyloxonium tetrafluoroborate. The analytes are separated, detected and quantified by gas chromatography–mass spectrometry in selected ion monitoring mode (SIM). The method was validated in terms of selectivity, capacity of identification, limits of detection (LOD) and quantification (LOQ), carryover, linearity, intra‐assay precision, inter‐assay precision and accuracy. The LOD and LOQ in hydrolyzed urine were 0.5 and 1.3 ng/mL for THC and 1.2 and 2.6 ng/mL for THC‐COOH, respectively. In blood, the LOD and LOQ were 0.2 and 0.5 ng/mL for THC, 0.2 and 0.6 ng/mL for OH‐THC, and 0.9 and 2.4 ng/mL for THC‐COOH, respectively. This method was applied to 35 urine samples and 50 blood samples resulting to be equivalent to the previously used ones with the advantage of a simpler method and faster sample processing time. We believe that this method will be a more convenient option for the routine analysis of cannabinoids in toxicological and forensic laboratories.
Tuning the Förster Resonance Energy Transfer through a Self‐Assembly Approach for Efficient White‐Light Emission in an Aqueous Medium
Authors: Pallavi Pragyan , Sk Bahadur , Ahir Palak , Patra Abhijit 
Published: November 2017

AbstractA simple and cost‐effective methodology employing environmentally benign substances for the fabrication of white‐light emitting materials is important for practical applications in the field of lighting and display devices. Designing purely organic‐based white‐light‐emitting systems with high quantum efficiency in aqueous media is an unmet challenge. With this objective, a new class of pyridoindole‐based hydrophobic fluorophore 6,7,8,9‐tetrapropylpyrido[1,2‐a]indole‐10‐carbaldehye (TPIC) was introduced. A strategy of self‐assembly using nonionic surfactants was employed to enhance the fluorescence of TPIC in an aqueous medium and was exploited as energy donor. The steady‐state and time‐resolved emission spectra analysis revealed the micelle‐mediated energy transfer from TPIC to Nile red (energy acceptor) leading to tunable fluorescence along with white‐light emission. The white‐light emitting aqueous solution was obtained with the Commission Internationale de l′Eclairage (CIE) chromaticity coordinates of (0.33, 0.36) and significantly high quantum yield of 37 %. Solid‐state white‐light emission was achieved retaining the assembly of fluorophores in the form of a gel having the high quantum efficiency of 33 % with CIE coordinates of (0.32, 0.36); close to that of pure white light. The bright white luminescence of the inscription prepared using white‐light emitting gel on a solid substrate offers promising applications for full‐color flat panel displays.