bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid novel test for the determination of biofouling potential on reverse osmosis membranes
Authors: Manalo Cervinia V. , Ohno Masaki , Okuda Tetsuji , Nakai Satoshi , Nishijima Wataru 
Published: April 2016

Abstract
A novel method was proposed to determine biofouling potential by direct analysis of a reverse osmosis (RO) membrane through fluorescence intensity analysis of biofilm formed on the membrane surface, thereby incorporating fouling tendencies of both feedwater and membrane. Evaluation of the biofouling potential on the RO membrane was done by accelerated biofilm formation through soaking of membranes in high biofouling potential waters obtained by adding microorganisms and glucose in test waters. The biofilm formed on the soaked membrane was quantified by fluorescence intensity microplate analysis. The soaking method's capability in detecting biofilm formation was confirmed when percentage coverage obtained through fluorescence microscopy and intensity values exhibited a linear correlation (R2 = 0.96). Continuous cross-flow experiments confirmed the ability and reliability of the soaking method in giving biofouling potential on RO membranes when a good correlation (R2 = 0.87) between intensity values of biofilms formed on the membrane during soaking and filtration conditions was obtained. Applicability of the test developed was shown when three commercially available polyamide (PA) RO membranes were assessed for biofouling potential. This new method can also be applied for the determination of biofouling potential in water with more than 3.6 mg L−1 easily degradable organic carbon.
Effects of three additives on the removal of perfluorooctane sulfonate (PFOS) by coagulation using ferric chloride or aluminum sulfate
Authors: Kishimoto Naoyuki , Kobayashi Masanori 
Published: April 2016

Abstract
Perfluorooctanesulfonic acid and its salts (PFOS) are emerging contaminants with long half-lives in water and human bodies. Accordingly, PFOS removal from water streams is required for controlling the PFOS pollution. To provide a simple PFOS separation technology, effects of three additives, powdered activated carbon (PAC), gelatin, and cetyltrimethylammonium bromide (CTAB), on the PFOS removal by coagulation with ferric chloride or aluminum sulfate were investigated in this study. As a result, coagulation with PAC or CTAB addition was effective in the PFOS removal, though the conventional coagulation and coagulation with gelatin addition were ineffective. A PFOS removal efficiency of over 90% was observed for the CTAB dose of over 1.6 μM (0.58 mg/L) and for the PAC dose of over 40 mg/L, and that of over 95% was achieved by the CTAB dose of over 2.4 μM (0.87 mg/L), when the initial PFOS concentration was 1.84 μM. The positive effect of CTAB would be caused by micelle formation, which was enhanced by both the association of hydrophobic tails and the electrostatic attraction of hydrophilic heads of PFOS and CTAB. Thus, a linear cationic surfactant of CTAB was concluded to be an effective additive for the PFOS removal by coagulation.
Sequential UASB and dual media packed-bed reactors for domestic wastewater treatment – experiment and simulation
Authors: Rodríguez-Gómez Raúl , Renman Gunno 
Published: April 2016

Abstract
A wastewater treatment system composed of an upflow anaerobic sludge blanket (UASB) reactor followed by a packed-bed reactor (PBR) filled with Sorbulite® and Polonite® filter material was tested in a laboratory bench-scale experiment. The system was operated for 50 weeks and achieved very efficient total phosphorus (P) removal (99%), 7-day biochemical oxygen demand removal (99%) and pathogenic bacteria reduction (99%). However, total nitrogen was only moderately reduced in the system (40%). A model focusing on simulation of organic material, solids and size of granules was then implemented and validated for the UASB reactor. Good agreement between the simulated and measured results demonstrated the capacity of the model to predict the behaviour of solids and chemical oxygen demand, which is critical for successful P removal and recovery in the PBR.
Modeling of Drug Delivery by A Pump Driven Micro-Needle Array System
Authors: Chen Kai , Pan Min , Feng Zhi-Gang 
Published: April 2016

Background:
Micro-needles were proposed as one of the alternatives to deliver drugs painlessly passing through stratum corneum in recent years. In this work, a mathematical model is presented to characterize the in fusion flow of a hollow micro-needle array driven by a micro-pump.

Methods:
By assuming the injection of each micro-needle undergoes a spherical expansion and diffusion, the model is able to calculate the time-varying expansion radius, and the diffusion boundary, provided that the material properties and the micro-needle system parameters are known.

Results and Conclusion:
The calculation results show that the expansion caused by the infusion of micro-needles stops and the flow rate drops to zero in a short time. However, the diffusion boundary is much bigger than the expansion and the infusion continues if the surrounding material is absorptive. The experimental results of jet infusion through a single needle in silicon rubber and polyacrylamide gel agree with the calculation results qualitatively.
The Effect of Client Lies on Auditor Memory Resistance and False Memory Acceptance
Authors: Brewster Billy E. 
Published: April 2016

SUMMARY
In this study, I examine the conditions that moderate auditor resistance toward and susceptibility to believing client-provided lies. In particular, I predict that auditors who cannot directly refute incorrect management explanations with their own evidence-related memories are susceptible to the misinformation effect. This effect describes a phenomenon where an individual recalls false memories, based on client lies, instead of his/her own real memories. I use a laboratory experiment involving professional auditors who must compile industry-related evidence to corroborate an invalid management explanation. As expected, I find that auditors with better-developed evidence memories provide lower evaluations of management credibility and explanation sufficiency when presented with a blatantly incorrect explanation. When subsequently prompted to access the related information, auditors with poorly developed evidence memories give responses that are consistent with management-provided false memories instead of their own previously gathered evidence memories. Auditors identifying the incorrect explanation did not succumb to the misinformation effect and exhibited recall more consistent with their own evidence memories. Overall, results show that client discussion can produce a delayed effect by inducing a form of memory error when the auditors subsequently retrieve evidence stored in their memory.
Data Availability: Contact the author for data availability.
Standards of Innovation in Auditing
Authors: Curtis Emer , Humphrey Christopher , Turley W. Stuart 
Published: April 2016

SUMMARY
This paper examines the impact of the development of Business Risk Auditing (BRA) on international audit standard setting and the implications regarding the potential for innovation in auditing practice. BRA was an audit methodology development promoted by the large international audit firms in the late 1990s as a significant innovation but, ultimately, it did not have the degree of impact on practice initially promised. Our analysis demonstrates that professional and regulatory priorities at the time interacted in ways that led to the most innovative elements of BRA not being advanced for inclusion in formal standards. Intriguingly this outcome was clear well before the critical attention given to auditing following Enron, which was the explanation offered for the fate of BRA in previous studies. We conclude that the capacity for innovative ideas to have a substantive influence on audit practice is highly dependent on interactions between a shifting mix of professional and regulatory interests and preferences. The BRA case illustrates how lasting innovation requires a willingness and commitment both to develop the scope of the audit and to accept variations in aspects of its execution. This will not happen if standardization per se is seen as an essential validation of successful innovation.
Experienced Executives' Views of the Effects of R&D Capitalization on Reputation-Driven Real Earnings Management: A Replication of Survey Data from Seybert (2010)
Authors: Seybert Nicholas 
Published: April 2016

ABSTRACT
This paper replicates the results of the survey of experienced executives reported in Section IV of Seybert (2010). The survey data from the originally published article were retracted due to concerns about the source of the data (see Seybert 2015). I survey 79 experienced executives to elicit their beliefs about reputation-driven real earnings management. Participants indicate that a manager would be more likely to continue a failing project, and that project abandonment would have a greater negative impact on the manager's reputation concerns and future prospects at the firm, when R&D is capitalized. Consistent with capital market pressures identified in prior research, executives believe that abandoning a failing project would have a greater negative impact on stock price when R&D is capitalized, and they personally recommend continuing such a project in order to avoid missing the consensus analysts' forecast. These findings complement the experimental results in Seybert (2010), and while they replicate the survey results contained therein, they are not an endorsement of the veracity of the original survey data.
Cauda Equina Compression in the Absence of Neurologic Signs
Authors: Buzzell Bethany , Sheets Charles , Bagley Carlos A. 
Published: April 2016

The patient was a 45-year-old man with a 4-year history of chronic low back pain, intensifying insidiously over the previous 8 months. On physical examination, generalized, severe low back pain was increased with all motions, with no abnormal neurologic signs. The initial physical therapy diagnosis was nonspecific low back pain; however, when the patient reported worsening symptoms at 2-week follow-up, he was advised to complete his previously scheduled magnetic resonance imaging and physician follow-up before further physical therapy. Magnetic resonance imaging revealed a mass at L5 consistent with benign nerve sheath tumor. J Orthop Sports Phys Ther 2016;46(4):312. doi:10.2519/jospt.2016.0405
The role of alternative anastomosis sites in occipital artery–posterior inferior cerebellar artery bypass in the absence of the caudal loop using the far-lateral approach
Authors: Fukuda Hitoshi , Evins Alexander I. , Iwasaki Koichi , Hattori Itaro , Murao Kenichi , Kurosaki Yoshitaka , Chin Masaki , Stieg Philip E. , Yamagata Sen , Bernardo Antonio 
Published: April 2016

OBJECTIVE
Occipital artery–posterior inferior cerebellar artery (OA-PICA) bypass is a technically challenging procedure for posterior fossa revascularization. The caudal loop of the PICA is considered the optimal site for OA-PICA anastomosis, however its absence can increase the technical difficulty associated with this procedure. The use of the far-lateral approach for accessing alternative anastomosis sites in OA-PICA bypass in patients with absent or unavailable caudal loops of PICA is evaluated.

METHODS
A morphometric analysis of OA-PICA bypass with anastomosis on each segment of the PICA was performed on 5 cadaveric specimens through the conventional midline foramen magnum and far-lateral approaches. The difficulty level associated with anastomoses at each segment was qualitatively assessed in each approach for exposure and maneuverability by multiple surgeons. A series of 8 patients who underwent OA-PICA bypass for hemodynamic ischemia or ruptured dissecting posterior fossa aneurysms are additionally reviewed and described, and the clinical significance of the caudal loop of PICA is discussed.

RESULTS
Anastomosis on the caudal loop could be performed more superficially than on any other segment (p < 0.001). A far-lateral approach up to the medial border of the posterior condylar canal provided a 13.5 ± 2.2–mm wider corridor than the conventional midline foramen magnum approach, facilitating access to alternative anastomosis sites. The far-lateral approach was successfully used for OA-PICA bypass in 3 clinical cases whose caudal loops were absent, whereas the midline foramen magnum approach provided sufficient exposure for caudal loop bypass in the remaining 5 cases.

CONCLUSIONS
The absence of the caudal loop of the PICA is a major contributing factor to the technical difficulty of OA-PICA bypass. The far-lateral approach is a useful surgical option for OA-PICA bypass when the caudal loop of the PICA is unavailable.
Biomechanics of transvertebral screw fixation in the thoracic spine: an in vitro study
Authors: Rodriguez-Martinez Nestor G. , Savardekar Amey , Nottmeier Eric W. , Pirris Stephen , Reyes Phillip M. , Newcomb Anna G. U. S. , Mendes George A. C. , Kalb Samuel , Theodore Nicholas , Crawford Neil R. 
Published: April 2016

OBJECTIVE
Transvertebral screws provide stability in thoracic spinal fixation surgeries, with their use mainly limited to patients who require a pedicle screw salvage technique. However, the biomechanical impact of transvertebral screws alone, when they are inserted across 2 vertebral bodies, has not been studied. In this study, the authors assessed the stability offered by a transvertebral screw construct for posterior instrumentation and compared its biomechanical performance to that of standard bilateral pedicle screw and rod (PSR) fixation.

METHODS
Fourteen fresh human cadaveric thoracic spine segments from T-6 to T-11 were divided into 2 groups with similar ages and bone quality. Group 1 received transvertebral screws across 2 levels without rods and subsequently with interconnecting bilateral rods at 3 levels (T8–10). Group 2 received bilateral PSR fixation and were sequentially tested with interconnecting rods at T7–8 and T9–10, at T8–9, and at T8–10. Flexibility tests were performed on intact and instrumented specimens in both groups. Presurgical and postsurgical O-arm 3D images were obtained to verify screw placement.

RESULTS
The mean range of motion (ROM) per motion segment with transvertebral screws spanning 2 levels compared with the intact condition was 66% of the mean intact ROM during flexion-extension (p = 0.013), 69% during lateral bending (p = 0.015), and 47% during axial rotation (p < 0.001). The mean ROM per motion segment with PSR spanning 2 levels compared with the intact condition was 38% of the mean intact ROM during flexion-extension (p < 0.001), 57% during lateral bending (p = 0.007), and 27% during axial rotation (p < 0.001). Adding bilateral rods to the 3 levels with transvertebral screws decreased the mean ROM per motion segment to 28% of intact ROM during flexion-extension (p < 0.001), 37% during lateral bending (p < 0.001), and 30% during axial rotation (p < 0.001). The mean ROM per motion segment for PSR spanning 3 levels was 21% of intact ROM during flexion-extension (p < 0.001), 33% during lateral bending (p < 0.001), and 22% during axial rotation (p < 0.001).

CONCLUSIONS
Biomechanically, fixation with a novel technique in the thoracic spine involving transvertebral screws showed restoration of stability to well within the stability provided by PSR fixation.
Clinical characteristics of arteriovenous malformations in the cerebellopontine angle cistern
Authors: Nishino Kazuhiko , Hasegawa Hitoshi , Morita Kenichi , Fukuda Masafumi , Ito Yasushi , Fujii Yukihiko , Sato Mitsuya 
Published: April 2016

OBJECTIVE
Arteriovenous malformations (AVMs) in the cerebellopontine angle cistern (CPAC) are specific lesions that can cause neurovascular compression syndromes as well as intracranial hemorrhage. Although case reports describing the CPAC AVMs, especially those presenting with trigeminal neuralgia (TN), have been accumulating by degrees, the pathophysiology of CPAC AVMs remains obscure. The authors' purpose in the present study was to evaluate the clinical and radiographic features of CPAC AVMs as well as the treatment options.

METHODS
This study defined a CPAC AVM as a small AVM predominantly located in the CPAC with minimal extension into the pial surface of the brainstem and closely associated with cranial nerves. All patients with CPAC AVMs treated in the authors' affiliated hospitals over a 16-year period were retrospectively identified. Clinical charts, imaging studies, and treatment options were evaluated.

RESULTS
Ten patients (6 men and 4 women), ranging in age from 56 to 77 years (mean 65.6 years), were diagnosed with CPAC AVMs according to the authors' definition. Six patients presented with hemorrhage, 3 with TN, and the remaining patient developed a hemorrhage subsequent to TN. Seven AVMs were associated with the trigeminal nerve (Group V), and 3 with the facial-vestibulocochlear nerve complex (Group VII–VIII). All patients in Group VII–VIII presented with the hemorrhage instead of hemifacial spasm. Regarding angioarchitecture, the intrinsic pontine arteries provided the blood supply for all CPAC AVMs in Group V. In addition, 5 of 7 AVMs with hemorrhagic episodes accompanied flow-related aneurysms, although no aneurysm was detected in patients with TN alone. With respect to treatment, all patients with hemorrhagic presentation underwent Gamma Knife surgery (GKS), resulting in favorable outcomes except for 1 patient who experienced rebleeding after GKS, which was caused by the repeated rupture of a feeder aneurysm. The AVMs causing TN were managed with surgery, GKS, or a combination, according to the nidus-nerve relationship. All patients eventually obtained pain relief.

CONCLUSIONS
Clinical symptoms caused by CPAC AVMs occur at an older age compared with AVMs in other locations; CPAC AVMs also have distinctive angioarchitectures according to their location in the CPAC. Although GKS is likely to be an effective treatment option for the CPAC AVMs with hemorrhagic presentations, it seems ideal to obliterate the flow-related aneurysms before performing GKS, although this is frequently challenging. For CPAC AVMs with TN, it is important to evaluate the nidus-nerve relationship before treatment, and GKS is especially useful for patients who do not require urgent pain relief.
Risk factors for hemorrhage associated with external ventricular drain placement and removal
Authors: Miller Catherine , Tummala Ramachandra P. 
Published: April 2016

OBJECTIVE
External ventricular drains (EVDs) have an important role in the management of neurological disease, and their placement is a frequently performed neurosurgical procedure. Hemorrhage is a common complication of EVD placement and occurs more frequently than originally believed. There is also risk of hemorrhage with removal of an EVD, which has not been well described. The authors investigated the risk factors associated with placement and removal of EVDs at their institution.

METHODS
A database was created including patients who required EVD placement from March 2008 to June 2014 at the University of Minnesota. A retrospective chart review was completed, and data were collected for each patient. All cranial imaging studies during the index hospitalization were reviewed to identify hemorrhages associated with either EVD placement or removal. The study was performed using a research protocol approved by the University of Minnesota's institutional review board.

RESULTS
Four hundred eighty-two EVDs were placed during the designated time period. Among the cases in which patients underwent imaging after the placement procedure, hemorrhage was found in 94 (21.6%). The hemorrhage volume ranged from 0.003 cm3 to 45.9 cm3 (mean [± SD] 1.96 ± 6.48 cm3). Two of these hemorrhages resulted in additional interventions: 1 surgical evacuation and 1 contralateral EVD. In 55 (22.5%) of the 244 cases in which imaging was performed after EVD removal, hemorrhage associated with removal was identified. The mean volume of these hemorrhages was 8.25 ± 20.34 cm3 (range 0.012–82.08 cm3). Two EVDs were replaced, and 1 patient died as a result of a large hemorrhage. Large hemorrhages (> 30 cm3) occurred in 2 patients on placement (0.46%) and in 5 patients on removal (2.0%). In this series, decreased platelet levels on admission and an increasing number of EVD placement attempts correlated with an increased risk of hemorrhage on placement. Only those with an EVD placed at bedside were more likely to have hemorrhage on EVD removal.

CONCLUSIONS
Multiple studies have reported varying EVD hemorrhage rates while very few studies have described hemorrhage secondary to EVD removal. This is the first reported analysis of risk factors associated with hemorrhage on EVD removal. Hemorrhages occur relatively frequently following EVD placement and removal, though clinical significance of these events seems to be low.
Avoidance of ischemic complications after resection of a brain lesion based on intraoperative real-time recognition of the vasculature using laser speckle flow imaging
Authors: Ideguchi Makoto , Kajiwara Koji , Yoshikawa Koichi , Goto Hisaharu , Sugimoto Kazutaka , Inoue Takao , Nomura Sadahiro , Suzuki Michiyasu 
Published: April 2016

OBJECTIVE
To avoid ischemic complications, it is important to consider the arteries in resection planning for lesions such as a vascular intraparenchymal tumor and arteriovenous malformation. Here, the clinical application of laser speckle flow imaging (LSFI) as a complementary method for the management of mass lesion–related arteries during surgery was evaluated.

METHODS
LSFI was performed in 12 patients with mass lesion–related arteries and brain tumor or arteriovenous malformation. The portable LSFI device was centered over the surgical field, and the relative cerebral blood flow (CBF) before and after the temporary interruption of the arteries was measured through continuous recording. CBF fluctuations permitted the classification of 3 kinds of artery—a feeding artery (FA), a “passing through” artery (PA), and a combined FA and PA (FA+PA)—based on decreased relative CBF in the inner resection area and unchanged CBF in the surrounding area (FA), unchanged CBF in the inner area and decreased CBF in the surrounding area (PA), or decreased CBF in both areas (FA+PA). This information allowed the appropriate management of these arteries and avoidance of postoperative ischemic complications.

RESULTS
Good visualization of CBF in the surgical field and relative CBF measurements in the regions of interest were achieved in real time with excellent spatiotemporal resolution. In 11 patients (92%) and 20 regions of interest, a decline in CBF was observed after temporary interruption of the FA (n = 8), PA (n = 2), and FA+PA (n = 2) types. There was a significant average reduction in CBF of 15.3% ± 29.0%. There were no ischemic complications, and only 1 patient had a postoperative ischemic lesion caused by resection through an artery that could not be viewed by LSFI due to a positional problem.

CONCLUSIONS
LSFI permits noninvasive and rapid intraoperative real-time recognition of mass lesion–related vasculature. This information can be used to avoid ischemic complications as a procedure complementary to neurophysiological monitoring.