bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dissociation between CSD-evoked metabolic perturbations and meningeal afferent activation and sensitization: implications for mechanisms of migraine headache onset
Authors: Zhao Jun , Levy Dan 
Published: June 2017

AbstractThe onset of the headache phase during attacks of migraine with aura, which occur in about 30% of migraineurs, is believed to involve cortical spreading depression (CSD) and the ensuing activation and sensitization of primary afferent neurons that innervate the intracranial meninges, and their related large vessels. The mechanism by which CSD enhances the activity and mechanosensitivity of meningeal afferents remains poorly understood, but may involve cortical metabolic perturbations. We employed extracellular single-unit recording of meningeal afferent activity and monitored changes in cortical blood flow and tissue partial pressure of oxygen (tpO2) in anesthetized male rats to test whether the prolonged cortical hypoperfusion and reduction in tissue oxygenation that occur in the wake of CSD contribute to meningeal nociception. Suppression of CSD-evoked cortical hypoperfusion with the cyclooxygenase inhibitor naproxen blocked the reduction in cortical tpO2, but had no effect on the activation of meningeal afferents. Naproxen, however, distinctly prevented CSD-induced afferent mechanical sensitization. Counteracting the CSD-evoked persistent hypoperfusion and reduced tpO2by preemptively increasing cortical blood flow using the K(ATP) channel opener levcromakalim did not inhibit the sensitization of meningeal afferents, but prevented their activation. Our data show that the cortical hypoperfusion and reduction in tpO2that occur in the wake of CSD can be dissociated from the activation and mechanical sensitization of meningeal afferent responses suggesting that the metabolic changes do not contribute directly to these neuronal nociceptive responses.Significance statementCSD-evoked activation and mechanical sensitization of meningeal afferents is thought to mediate the headache phase in migraine with aura. We report that blocking the CSD-evoked cortical hypoperfusion and reduced tpO2by cyclooxygenase inhibition is associated with the inhibition of the afferent sensitization but not their activation. Normalization of these CSD-evoked metabolic perturbations by activating K(ATP) channels is, however, associated with the inhibition of afferent activation but not sensitization. These results question the contribution of cortical metabolic perturbations to the triggering mechanism underlying meningeal nociception and the ensuing headache in migraine with aura, further point to distinct mechanisms underlying the activation and sensitization of meningeal afferents in migraine and highlight the need to target both processes for an effective migraine therapy.
DeepARG: A deep learning approach for predicting antibiotic resistance genes from metagenomic data
Authors: Arango-Argoty G. A. , Garner E. , Pruden A. , Heath L. S. , Vikesland P. , Zhang L. 
Published: June 2017

ABSTRACTGrowing concerns regarding increasing rates of antibiotic resistance call for global monitoring efforts. Monitoring of environmental media (e.g., wastewater, agricultural waste, food, and water) is of particular interest as these media can serve as sources of potential novel antibiotic resistance genes (ARGs), as hot spots for ARG exchange, and as pathways for the spread of ARGs and human exposure. Next-generation sequence-based monitoring has recently enabled direct access and profiling of the total metagenomic DNA pool, where ARGs are identified or predicted based on the “best hits” of homology searches against existing databases. Unfortunately, this approach tends to produce high rates of false negatives. To address such limitations, we propose here a deep leaning approach, taking into account a dissimilarity matrix created using all known categories of ARGs. Two models, deepARG-SS and deepARG-LS, were constructed for short read sequences and full gene length sequences, respectively. Performance evaluation of the deep learning models over 30 classes of antibiotics demonstrates that the deepARG models can predict ARGs with both high precision (>0.97) and recall (>0.90) for most of the antibiotic resistance categories. The models show advantage over the traditional best hit approach by having consistently much lower false negative rates and thus higher overall recall (>0.9). As more data become available for under-represented antibiotic resistance categories, the deepARG models’ performance can be expected to be further enhanced due to the nature of the underlying neural networks. The deepARG models are available both in command line version and via a Web server athttp://bench.cs.vt.edu/deeparg. Our newly developed ARG database, deepARG-DB, containing predicted ARGs with high confidence and high degree of manual curation, greatly expands the current ARG repository. DeepARG-DB can be downloaded freely to benefit community research and future development of antibiotic resistance-related resources.AbbreviationsARGantibiotic resistance gene
A hybrid SD-DEMATEL approach to develop a delay model for construction projects
Authors: Parchami Jalal Majid , Shoar Shahab 
Published: June 2017

Purpose
The purpose of this paper is to develop a model for complex interconnected structure of various factors interacting with delay in order to identify the most important factors influencing and influenced by delay based on their interrelations.

Design/methodology/approach
Reviewing literature and interviewing with local experts selected from the Iranian construction industry, top 58 delay factors were identified and categorized into six major groups. The interrelations among these factors were, then, modeled using the system dynamics (SD) approach. The resulting causal loop diagrams obtained from SD were used subsequently for identifying the most significant factors influencing and influenced by delay through the Decision Making Trial and Evaluation Laboratory (DEMATEL) method. The impact of factors on each other was finally determined based on the opinions of 63 experts selected from the Iranian community of consultants, contractors, and clients.

Findings
According to the analysis, eight out of the 58 factors were identified as the most influencing factors on delay, and nine factors were found to be the most influenced factors by delay in the field of delay analysis. The study also concluded that factors related to labors are the most important and influential factors. In addition, factors related to client were the most influencing factors and external-related factors were the least important ones. At the end, some recommendations to reduce variation of delay in the construction projects are presented as well.

Originality/value
Considering the interconnected structure of the factors, the paper identifies the most important factors interacting with time delay in construction projects.
Quantifying gender distances in education, occupation and employment
Authors: Symeonaki Maria , Filopoulou Celestine 
Published: June 2017

PurposeThe purpose of this paper is to investigate the role of gender in education, occupation and employment in Southern Europe and more specifically in Greece, Italy, Portugal and Spain. The goal is to provide measures that can trace gender differences with respect to their educational and employment features in these countries, explore whether these differences converge over time and compare the patterns observed in each country given their socio-economic similarities.Design/methodology/approachThis paper uses raw data drawn from the European Social Survey (ESS) for the decade 2002-2012. It provides a method for quantifying gender differences in education, occupation and employment and their evolution over time based on distance measures.FindingsThe results reveal that gender distances in education have gradually subsided in these countries. However, occupational choices differ steadily over the years for all countries. The paper provides, therefore, solid evidence that equalizing the level of education between men and women during those years did not result in a decrease in the occupational distances between them. Moreover, based on the latest round the findings suggest that men and women are equally likely to having experienced unemployment within the last five years.Research limitations/implicationsFurther research could be done to include results based on raw data from the seventh round of the ESS. This may provide valuable information for Spain and Portugal who did participate in this round.Social implicationsThis research implies that more needs to be done to accelerate progress in order to achieve gender occupational equality in Southern Europe.Originality/valueThis paper draws attention to issues concerning gender differences in education, horizontal and vertical segregation and employment for which it provides distance measures and evidence of how they have evolved over time, based on raw data analysis from the ESS.
Communicating technological innovations
Authors: Wagner Timm F. , Baccarella Christian V. , Voigt Kai-Ingo 
Published: June 2017

PurposeConsumers’ perceptions of new technologies are vital for the adoption of innovations. However, due to the complexity of technological innovations and associated consumer concerns, marketing communications play a crucial role in shaping attitudes. In this context, the level of technical complexity presented in advertisements can be a critical determinant of communication effectiveness. The paper aims to discuss this issue.Design/methodology/approachBy conducting an experiment in the context of plug-in hybrid electric cars, this study examines the impact of technical complexity on communication effectiveness. The authors also include consumers’ product involvement as a potential moderator of this relationship.FindingsThis paper reveals that individuals with low product involvement respond more favourably to technically simple ads. However, medium-involved consumers show the best responses towards ads with a high level of technical complexity. Interestingly, the authors could not find significant attitude differences for high-involvement individuals in terms of the level of technical complexity.Practical implicationsThe results support the notion that the advice “keep it short and simple” is not always appropriate. In particular, when marketers want to communicate technological innovations, a more complex presentation can provoke positive reactions, when the audience has at least a medium level of product involvement.Originality/valueThere is little evidence concerning how technical complexity within marketing communications affects consumer attitudes. This study significantly contributes to the understanding of how advertisements of technological innovations are perceived by consumers.
Trust, integrated information technology and new product success
Authors: Ettlie John E. , Tucci Christopher , Gianiodis Peter T. 
Published: June 2017

PurposeThe purpose of this paper is to investigate the combined roles via trust relationships of the two technology cores of the firm: information technology (IT) and R&D and their impact on new product success.Design/methodology/approachA model was tested whereby trust and the integrated IT strategy account for a significant amount of the variance in a broad range of new product development (NPD) outcomes for a survey sample of 223 manufacturing firms. Respondents said design practices and quality methods like Six Sigma accounted for a total of over 25 percent of the reports of the most helpful approaches in promoting effective NPD. At the same time their biggest challenges were having a clear strategic direction within which to operate and resolving cost and resource issues which accounted for over a third (34 percent) of barriers to success.FindingsRespondents reported that a total of over 25 percent of the reports of the most helpful approaches in promoting effective included these quality methods. At the same time their biggest challenges were having a clear strategic direction within which to operate and resolving cost and resource issues which accounted for over a third (34 percent) of barriers to success. High-tech firms were less likely to report integrated IT strategies, but this tended to be counterbalanced by high levels of trust in the IT function and adoption of organizational innovations for execution of strategic intent. Implications for future research and practice are discussed.Research limitations/implicationsSurvey methods produce broad results with low response rates in most studies involving R&D and NPD, and this study is no exception.Practical implicationsWith the challenge of strategy alignment reported by many of these firms, it seems clear that the top management team cannot afford to leave NPD challenges to engineering teams and NPD programs without guidance and general vision.Social implicationsNPD has become the staple of most manufacturing firms as a way of meeting and beating the competition worldwide. However, trust between functional areas often starts before people are even employed and should begin in training and educational programs.Originality/valueDesigning NPD programs is at the heart of many firms’ competitive strategies and the fast learning companies are the winners. Very little is known about the trust relationship between IT and R&D and their combined effects on new product success which we have found to be significant and unexpected in their impacts.
The importance of the evaluation of expectations and perceptions to improve the dental service quality
Authors: Rocha Juliana , Pinto Andres , Batista Marilia , Paula Janice Simpson de , Ambrosano Glaucia 
Published: June 2017

Purpose
The purpose of this paper is to evaluate the use of SERVQUAL to assess service quality in Dentistry, by evaluating patients’ expectations and perceptions of dental care and their association to patients’ sociodemographic data.

Design/methodology/approach
The sample constituted of 379 subjects in the first assessment and 155 in the second phase. All employees of the companies that were clients of the dental insurance participated, a total of four companies in two states (São Paulo and Minas Gerais) of Brazil. SERVQUAL questionnaires about expectations and sociodemographic data were dispatched in the first phase, and in a second phase SERVQUAL questionnaires about perceptions. Those who had not yet received dental treatment and had agreed to participate filled out their survey in the first phase. In the second phase, the respondents had to have completed their treatment.

Findings
When the value gap is considered, Reliability (as a dimension) had the smallest score (−3.71). This means that it was the worst result, i.e. there is a higher difference between expectations and perceptions, and problems can be identified here. t-test confirmed that all the dimensions had some statistically significant difference with p<0.05 in relation to expectations and perceptions. Women presented higher prevalence of dissatisfaction (Tangible and Reliability dimensions), as well as the oldest participants (Empathy dimension) and those with lower parental literacy (Assurance and Empathy dimensions). The only dimension that was not significantly associated was Responsiveness.

Originality/value
This research suggests that the patients evaluated the physical characteristics of the premises and the interaction with the staff as the priority issues that need special attention in this service. Moreover, the use of SERVQUAL was extremely relevant for the oral health service, because it assessed the users’ subjective perceptions.
Efficiency of inpatient orthopedic surgery in Japan: a medical claims database analysis
Authors: Nakata Yoshinori , Yoshimura Tatsuya , Watanabe Yuichi , Otake Hiroshi , Oiso Giichiro , Sawa Tomohiro 
Published: June 2017

Purpose
The purpose of this paper is to determine the characteristics of healthcare facilities that produce the most efficient inpatient orthopedic surgery using a large-scale medical claims database in Japan.

Design/methodology/approach
Reimbursement claims data were obtained from April 1 through September 30, 2014. Input-oriented Banker-Charnes-Cooper model of data envelopment analysis (DEA) was employed. The decision-making unit was defined as a healthcare facility where orthopedic surgery was performed. Inputs were defined as the length of stay, the number of beds, and the total costs of expensive surgical devices. Output was defined as total surgical fees for each surgery. Efficiency scores of healthcare facilities were compared among different categories of healthcare facilities.

Findings
The efficiency scores of healthcare facilities with a diagnosis-procedure combination (DPC) reimbursement were significantly lower than those without DPC (p=0.0000). All the efficiency scores of clinics with beds were 1. Their efficiency scores were significantly higher than those of university hospitals, public hospitals, and other hospitals (p=0.0000).

Originality/value
This is the first research that applied DEA for orthopedic surgery in Japan. The healthcare facilities with DPC reimbursement were less efficient than those without DPC. The clinics with beds were the most efficient among all types of management bodies of healthcare facilities.
Reducing wrong intraocular lens implants in cataract surgery
Authors: Loh Huey Peng , de Korne Dirk Frans , Chee Soon Phaik , Mathur Ranjana 
Published: June 2017

Purpose
Wrong lens implants have been associated with the highest frequency of medical errors in cataract surgery. The purpose of this paper is to explore the use of the Systems Engineering Initiative for Patient Safety (SEIPS) framework to sustainably reduce wrong intraocular lens (IOL) implants in cataract surgery.

Design/methodology/approach
In this mixed-methods study, the SEIPS framework was used to analyse a series of (near) misses of IOL implants in a national tertiary specialty hospital in Singapore. A series of interventions was developed and applied in the case hospital. Risk assessment audits were done before the interventions (2012; n=6,111 surgeries), during its implementation (n=7,475) and in the two years post-interventions (2013-2015; n=39,390) to compare the wrong IOL-rates.

Findings
Although the absolute number of incidents was low, the incident rate decreased from 4.91 before to 2.54 per 10,000 cases after. Near miss IOL error decreased from 5.89 before to 3.55 per 1,000 cases after. The number of days between two IOL incidents increased from 35 to an initial peak of 385 before stabilizing on 56. The large variety of available IOL types and vendors was found as the main root cause of wrong implants that required reoperation.

Practical implications
The SEIPS framework seems to be helpful to assess components involved and develop sustainable quality and safety interventions that intervene at different levels of the system.

Originality/value
The SEIPS model is supportive to address differences between person and system root causes comprehensively and thereby foster quality and patient safety culture.
Culture and social identity in preserving cultural heritage: an experimental study
Authors: Chng Kean Siang , Narayanan Suresh 
Published: June 2017

PurposeDue to the non-rivalrous and non-excludable characteristics of properties classified as being part of the cultural heritage of a city, owners of these properties face a lower incentive to maintain them. Many studies have advocated the participation of the local community in the maintenance of such “public” properties because community demands and tastes are better reflected through direct participation than through government intervention. One of the main factors that may determine whether or not such participation would be forthcoming is whether the community identifies with elements that the cultural heritage building represents. The purpose of this paper is to examine the cultural effects of the Chinese community with regard to the preservation of the heritage buildings that reflect the community’s early presence in George Town, Penang.Design/methodology/approachAn experimental method was used to invoke feelings of social identity through historical and cultural photos about these buildings associated with the community. The authors attempted to create an emotional attachment to the cultural and historical values in a laboratory.FindingsThe authors found that information increased the participants’ positive feelings toward their historical and cultural backgrounds. This positive emotion might explain why the subjects appeared more willing to contribute to the public pool to maintain these buildings. The findings suggest that the incorporating cultural and historical information about heritage buildings may encourage more pro-social behaviors.Social implicationsAlthough community participation and discussions can help to align the conservation objectives of diverse stakeholders, the divergence between individual and collective interests may cause individuals to shirk from their commitment, given the public nature of the goods. Therefore, investigating whether a factor that aligns diverse interests or the nature of the game can influence behavior is important to the development of strategies used in the provision of public good.Originality/valueAlthough the impact of social identity on social dilemma has been widely studied, the empirical proof and its application to preservation of cultural heritage has not been studied. As far as the authors know, this is the first paper that experimentally proves the importance of social identity and its role in provision of social goods.
Does ESG performance have an impact on financial performance? Evidence from Germany
Authors: Velte Patrick 
Published: June 2017

Purpose
The purpose of this paper is to concentrate on environmental, social and governance performance (ESGP) in total and divided in each component and evaluate their impact on financial performance (FINP).

Design/methodology/approach
The study covers a sample selection of companies listed on the German Prime Standard (DAX30, TecDAX, MDAX) for the business years 2010-2014 (412 firm-year observations). A correlation and regression analysis was carried out to evaluate possible links between ESGP as determined by the Asset4 database of Thomson Reuters and accounting and market-based measures of FINP (Return on Assets [ROA] and Tobin’s Q).

Findings
ESGP has a positive impact on ROA but no impact on Tobin’s Q. Furthermore, by analyzing the three different components of ESGP, governance performance has the strongest impact on FINP in comparison to environmental and social performance.

Originality/value
The analysis makes a key contribution to the empirical corporate social responsibility (CSR) research as the author breaks down ESGP into their three components and include both accounting-based and market-based FINP measures for the German setting for the first time. Not only companies but also regulators and researchers are affected by the notion that CSR and FINP are close together and should be lead to a successful stakeholder management.