bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axis
Authors: Erkosar Berra , Dupuis Cindy , Savary Loriane , Kawecki Tadeusz J. 
Published: September 2024

AbstractShared developmental, physiological and molecular mechanisms can generate strong genetic covariances across suites of traits, constraining genetic variability and evolvability to certain axes in multivariate trait space (“variational modules” or “syndromes”). Such trait suites will not only respond jointly to selection; they will also covary across populations that diverged from one another by genetic drift. We report evidence for such a genetically correlated trait suite inDrosophila melanogaster. It links high expression of glycolysis and TCA cycle genes, high abundance of mitochondria and high spontaneous locomotor activity with low degree of adiposity, and low endurance and early death under starvation. This “power-endurance” axis is also aligned with abundance of certain metabolites, notably low trehalose (blood sugar) and high levels of some amino acids and their derivatives, including creatine, a compound known to facilitate energy production in muscles. Our evidence comes from six replicate “Selected” populations adapted to a nutrient-poor larval diet regime during 250 generations of experimental evolution and six “Control” populations evolved in parallel on a standard diet regime. We found that, within each of these experimental evolutionary regime, the above traits strongly covaried along the power-endurance axis across replicate populations which diversified by drift, indicating a shared genetic architecture. The two evolutionary regimes also drove divergence along this axis, with Selected populations on average displaced towards the “power” direction compared to Controls. Aspects of this “power-endurance” axis resemble the “pace of life” syndrome and the “thrifty phenotype”; it may have evolved as part of a coordinated organismal response to nutritional conditions.
Mutation and recombination parameters in zebra finch are similar to those in mammals
Authors: Prentout Djivan , Bykova Daria , Hoge Carla , Hooper Daniel M. , McDiarmid Callum S. , Wu Felix , Griffith Simon C. , de Manuel Marc , Przeworski Molly 
Published: September 2024

AbstractMost of our understanding of the fundamental processes of mutation and recombination stems from a handful of disparate model organisms and pedigree studies of mammals, with little known about other vertebrates. To gain a broader comparative perspective, we focused on the zebra finch (Taeniopygia castanotis), which, like other birds, differs from mammals in its karyotype (which includes many micro-chromosomes), in the mechanism by which recombination is directed to the genome, and in aspects of ontogenesis. We collected genome sequences from three generation pedigrees that provide information about 80 meioses, inferring 202 single-pointde novomutations, 1,174 crossovers, and 275 non-crossovers. On that basis, we estimated a sex-averaged mutation rate of 5.0 × 10−9per base pair per generation, on par with mammals that have a similar generation time (∼2-3 years). Also as in mammals, we found a paternal germline mutation bias at later stages of gametogenesis (of 1.7:1) but no discernible difference between sexes in early development. Examining recombination patterns, we found that the sex-averaged crossover rate on macro-chromosomes (1.05 cM/Mb) is again similar to values observed in mammals, as is the spatial distribution of crossovers, with a pronounced enrichment near telomeres. In contrast, non-crossover rates are more uniformly distributed. On micro-chromosomes, sex-averaged crossover rates are substantially higher (4.21 cM/Mb), as expected from crossover homeostasis, and both crossover and non-crossover events are more uniformly distributed. At a finer scale, recombination events overlap CpG islands more often than expected by chance, as expected in the absence of PRDM9. Despite differences in the mechanism by which recombination events are specified and the presence of many micro-chromosomes, estimates of the degree of GC-biased gene conversion (59%), the mean non-crossover conversion tract length (∼32 bp), and the non-crossover-to-crossover ratio (5.4:1) are all comparable to those reported in primates and mice. The similarity of mutation and recombination properties in zebra finch to those in mammals suggest that they are conserved by natural selection.
CRISPR-Cas9 target-strand nicking provides phage resistance by inhibiting replication
Authors: Nguyen Giang T. , Schelling Michael A. , Sashital Dipali G. 
Published: September 2024

AbstractCas endonucleases, like Cas9 and Cas12a, are RNA-guided immune effectors that provide bacterial defense against bacteriophages. Cas endonucleases rely on divalent metal ions for their enzymatic activities and to facilitate conformational changes that are required for specific recognition and cleavage of target DNA. While Cas endonucleases typically produce double-strand breaks (DSBs) in DNA targets, reduced, physiologically relevant Mg2+concentrations and target mismatches can result in incomplete second-strand cleavage, resulting in the production of a nicked DNA. It remains poorly understood whether nicking by Cas endonucleases is sufficient to provide protection against phage. To address this, we tested phage protection by Cas9 nickases, in which only one of two nuclease domains is catalytically active. By testing a large panel of guide RNAs, we find that target strand nicking can be sufficient to provide immunity, while non-target nicking does not provide any additional protection beyond Cas9 binding. Target-strand nicking inhibits phage replication and can reduce the susceptibility of Cas9 to viral escape when targeting non-essential regions of the genome. Cleavage of the non- target strand by the RuvC domain is strongly impaired at low Mg2+concentrations. As a result, fluctuations in the concentration of other biomolecules that can compete for binding of free Mg2+strongly influences the ability of Cas9 to form a DSB at targeted sites. Overall, our results suggest that Cas9 may only nick DNA during CRISPR-mediated immunity, especially under conditions of low Mg2+availability in cells.
Is OFDI persistence beneficial for firms' performance? Evidence from Chinese firms
Authors: Ding Sasa , Liu Yajun , Huang Yi 
Published: September 2024

PurposeBased on organizational learning theory, this study aims to investigate the performance consequences and potential contextual factors of outward foreign direct investment (OFDI) persistence.Design/methodology/approachA regression analysis was conducted on a sample of 19,950 OFDI events of 1,425 A-share listed Chinese enterprises from 2008 to 2022. The estimator used was ordinary least squares with residual analysis, which allowed us to obtain robust and reliable results.FindingsThe results indicated that persistence in both greenfield investments and cross-border M&As had a significant and positive impact on firm performance, and such relationship was positively moderated by organizational absorptive capacity.Research limitations/implicationsThis study only tested the economic performance of OFDI persistence rather than innovation and social performance. Exploring the effects of OFDI persistence on other aspects may also add new insights to the persistence literature. Besides absorptive capacity, it might be useful to conduct a more comprehensive consideration of moderators in the future.Originality/valueThis paper contributes to the research on the temporal dimension of internationalization by introducing the concept of OFDI persistence. Additionally, we used the OFDI spell to capture the notion of OFDI persistence, which is an endeavor to overcome the shortcomings of the traditional indicator. Finally, this paper also contributes to the organizational learning perspective by applying it to analyze persistent OFDI operations.
The impact of information and communication technology infrastructure on divorce for a sample of developed countries for the period 2012-2021
Authors: Lakhdari Boulenouar 
Published: September 2024

Purpose
This study aims to measure the impact of information and communication technology (ICT) infrastructure on divorce for a sample of developed countries for the period (2012-2021).

Design/methodology/approach
This paper uses fixed effect and generalized method of moments (GMM) estimation to delve into the impact of eight ICT infrastructure factors on divorce. The analyses are based on data collected from the World Bank Development Indicators.

Findings
The fixed effect analysis revealed that an increase in both fixed-telephone subscriptions and population covered by at least a 4G led to an increase in divorce. However, an increase in mobile cellular subscriptions and active mobile broadband subscriptions lead to a decrease in divorce. The results of the GMM estimator showed that fixed broadband internet prices, mobile broadband internet prices, the percentage of the population covered by the 4 G mobile network and fixed-telephone subscriptions had a substantial effect on divorce. While fixed broadband subscriptions, active mobile broadband subscriptions and mobile cellular basket were found to hinder divorce.

Research limitations/implications
The findings of this study contribute to the existing literature by highlighting the impact of ICT on divorce in a sample of developed countries. Furthermore, it helps decision-makers and families to understand the causes of divorce related to ICT infrastructure in these societies, so they can understand this phenomenon and provide proactive policies.

Originality/value
This study used multiple factors to measure ICT infrastructure as well as the GMM estimator to delve into the impact of ICT on divorce.
A scoping review on combating workplace violence against psychiatry residents
Authors: Oyetunji Aderonke , Bunte Kailee , Bellman Val 
Published: September 2024

Purpose
This paper aims to illuminate the issue of workplace violence (WPV) against psychiatry residents. Workplace violence is known to negatively impact physical and emotional well-being, professional development and the quality of the care that mental health professionals provide to patients. The authors discuss the prevalence of, risk factors for and consequences of WPV against psychiatry residents, as well as the need for support and resources to help residents cope with the emotional challenges of their job.

Design/methodology/approach
This paper is a review of the literature on WPV against psychiatry residents, and includes studies on its prevalence, associated risk factors and consequences.

Findings
Psychiatry residents face a heightened risk of WPV, including physical and verbal attacks, which can harm their mental and physical health and disrupt their continuity of care. Factors that contribute to WPV against psychiatry residents include exposure to aggressive or violent behaviors, inadequate training in WPV, understaffing, the stigmatization of mental illnesses, and discriminatory treatment. Furthermore, psychiatry residents who encounter WPV may develop negative emotions and attitudes toward their patients, which can compromise the care they provide.

Research limitations/implications
The inherent heterogeneity of study designs highlighted in this review could hinder the establishment of definitive conclusions about the impact of workplace violence on psychiatry residents. A focus on studies published in English may inadvertently exclude relevant literature in other languages, potentially limiting the comprehensiveness of study findings.

Originality/value
This paper highlights resident physicians’ personal experiences with and perceptions of WPV encountered during residency training. In response, potential solutions are proposed to address WPV, including increased support for resident physicians, mandatory reporting of WPV incidents, and a cultural shift toward zero tolerance for WPV. In addition, the paper raises awareness of the limited research on this topic and the importance of further investigation.
Dissatisfaction with professional accountant training: the role of learning styles
Authors: Malthus Sue , Fowler Carolyn , Cordery Carolyn J. 
Published: September 2024

Purpose
Prior research finds that early-career professional accountants (early PAs) are generally dissatisfied with the learning and training opportunities offered during their early employment years, which impacts their career progression. This paper aims to examine whether different learning styles between these early PAs and their qualified accounting employers and trainers diverge.

Design/methodology/approach
Using Kolb’s learning styles inventory and interviews, this study explores the learning styles of early PAs and their employers, examining changes in these learning styles over time.

Findings
This research shows the necessity for different learning styles to be integrated into early PA training and learning, as research participants’ learning styles tend to prefer active experimentation requiring practical examples and self-learning opportunities. In contrast, their senior, qualified accounting employers prefer conceptualisation-based learning styles. As early PAs’ career progression requires them to succeed in employer-supported training, some early PAs change their learning style preferences to progress, whereas others with incompatible learning styles either moved to different employers or reassessed their choice of profession.

Practical implications
To reduce career dissatisfaction, develop and retain competent accountants, early PAs must be supported to learn effectively. By reducing early PAs’ dissatisfaction early PA educators and employers will potentially increase the attractiveness of accounting as a profession.

Originality/value
Few studies interrogate how accounting professionals utilise learning and training post-graduation nor do they examine the learning styles of workplace trainers and learners. This exploratory study uniquely analyses the learning styles of both early PAs and their employers.
Earnings management, key audit matters and audit report readability
Authors: Chen Tsung-Kang , Hung Yu-Shun , Tseng Yijie , Hsiao Kan-Yi 
Published: September 2024

Purpose
According to the management obfuscation hypothesis, managers have incentives to influence the audit reports’ communicative value. This study aims to examine the relationship between corporate earnings management and the readability of Chinese-text audit reports and the impact of key audit matter (KAM) disclosure requirements on this relationship.

Design/methodology/approach
This research adopts Taiwanese firms from 2010 to 2019 to investigate the association between earnings management and readability of Chinese-text audit reports within the framework of the KAM disclosure requirements implemented in 2016.

Findings
The findings show that auditors tend to issue less readable audit reports to firms undertaking earnings management, particularly after introducing KAM disclosures. Additional analyses indicate that such adverse impacts of client earnings management on audit report readability have become more pronounced for firms audited by a newly pointed or long-tenure lead audit partner, with high business risk, poor monitoring of governance mechanisms or a large amount of nonaudit services. These results suggest that auditor partners may compromise auditor independence and use flexible narratives in audit reports as a form of moral insurance.

Practical implications
As auditors may manage audit report readability to reduce audit liability, authorities must formulate policies concerning audit report disclosure to strengthen its communicative value and simplify language usage. Additionally, authorities should strengthen quality control standards concerning auditor independence to reduce auditor pressure from clients’ economic importance.

Originality/value
This study provides valuable insights into auditors' responses to corporate earnings management behavior, particularly regarding the interplay between earnings management, audit report quality and regulatory changes, thus expanding our understanding of the dynamics within the auditing profession.
Synthesis of imino methyl-etherified amino resin by one-step two-stage catalysis and its application in high solid content coating
Authors: Yang Xingbing , Wang Xinye , Li Wei , Zhang Tingting , Yan Mengmeng , Fu Xue 
Published: September 2024

Purpose
This paper aims to study the direct synthesis of imino methyl ether amino resin using commercially available formaldehyde, melamine and methanol through one-step two-stage catalysis.

Design/methodology/approach
Initially, melamine undergoes a reaction with formaldehyde to form hydroxylmethylation melamine in a basic setting. Subsequently, hydrochloric acid is incorporated to facilitate the etherification process. The study delves into the impact of various factors during the etherification phase, including the quantity of methanol, the temperature at which etherification occurs, the number of etherification cycles and the amount of catalyst used, on the synthesis of imino methyl-etherified amino resins. Ultimately, the most favorable conditions for etherification are identified through comparative analysis to evaluate the resulting synthesized products.

Findings
The methyl-etherified amino resin, characterized by a stable structure and consistent performance, was efficiently synthesized through a one-step, two-stage catalytic process. Optimal conditions for the etherification stage were determined to be a reaction temperature of 35°C, a melamine to methanol ratio of 1:24 and an addition of hydrochloric acid ranging from 2.2 mL to 2.5 mL. Remarkably, the resulting resin notably enhanced the water resistance, salt resistance and gloss of the canned iron printing varnish coatings.

Originality/value
Amino resins, known for their broad applications across numerous industries, face sustainability and operational efficiency hurdles when produced through traditional methods, which predominantly involve the use of a 37% formaldehyde solution. To tackle these issues, our research introduces an innovative method that add 37% formaldehyde to facilitate industrial production. The use of 37% liquid formaldehyde in this paper has two benefits: first, it is convenient for industrial application and production; Second, it is convenient to provide mild reaction conditions at lower concentrations because the amino group is relatively active, which is convenient for the preservation of the amino group and integrates it with a one-step, two-stage catalytic process. The primary objective of our study is threefold: to reduce the environmental footprint of amino resin synthesis, to optimize the use of resources and to improve the economic viability for its large-scale production. By employing this new strategy, we try to provide a more sustainable and efficient manufacturing process for amino resins.
Exploring mechanical behavior at interfaces of laser powder bed fusion (LPBF) deposits on wrought Inconel 718: an indentation-based approach
Authors: Shrivastava Abhishek , S. Anand Kumar , Rao Samrat 
Published: September 2024

Purpose
This study used an indentation-based mechanical testing framework for the mechanical characterization of laser powder bed fusion (LPBF) processed Inconel 718 on a wrought Inconel 718 substrate. The purpose of the paper is to investigate the effectiveness of the indentation-based approach for localized mechanical evaluation.

Design/methodology/approach
The LPBF-processed wrought substrate was sectioned into three sections for microstructural and mechanical characterization. A 3D heat source model was used for the thermal analysis of the interface region. The developed interface region is probed using the Knoop hardness indenter in different orientations to determine the textural anisotropy and mechanical behavior of the region.

Findings
LPBF process develops a melted interface zone (MIZ) at the deposition-substrate interface. The MIZ exhibited a coarse grain structure region along with a larger primary dendritic arm spacing (PDAS), signifying a slower cooling rate. FE modeling of the LPBF process reveals heat accumulation in the substrate along with intrinsic heat treatment (IHT) induced due to layer-wise processing. The obtained yield locus shows strong anisotropy in the deposition region, whereas reduced anisotropy with a nearly uniform ellipse locus for the MIZ regions. This reduced anisotropy is attributable to IHT and heat accumulation in the substrate.

Originality/value
An alternative localized mechanical characterization tool has been investigated in this work. The approach proved sensitive to thermal variations during LPBF processing in an isolated region which extends its suitability to variable geometry parts. Moreover, the approach could serve as a screening tool for parts made from dissimilar metals.
Environmental and ecological drivers of eye size variation in a freshwater predator: A trade‐off between foraging and predation risk
Authors: Andersson Matilda L. , Scharnweber Kristin , Eklöv Peter 
Published: September 2024

Abstract

Variations in the size and shape of the eye have been observed in many species of fish. As eye size is positively related to visual acuity, larger eyes should favour foraging and detection of predators.

However, few studies have examined the variation in eye morphology in relation to the complexity of lake conditions, including environmental perturbation and spatial variation in predation and competition. Such tests are especially important as the degrading of the visual climate is expected due to climate change, where browning, turbidity and variations in structural complexity should set different demands for visual acuity of foraging fish under predation risk.

In this study, we tested the variation of the eye size among 667 individuals of an aquatic predator perch, Perca fluviatilis, from littoral and pelagic habitats of 14 lakes. We used Secchi depth to assess the effects of the visual climate of our lake systems, as fish foraging is highly related to visual conditions, and studied eye size variation in relation to the contribution of the pelagic resources to an individual's diet and the risk of predation.

Secchi depth, the pelagic contribution to the diet and the percentage of piscivores had significant effects on eye size.

These variable outcomes suggest that the lake environment in terms of visual climate, predation landscape and diet are major factors of eye size variation in this generalist predator. As many fish species trade off foraging against predation risk, future studies will show whether the complexity of intra‐ and interspecific interactions contribute to the variation in eye size in freshwater fish.

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