bluuebunny/crossref_metadata_2025_split huggingface dataset:
A meta‐analysis of the association between vasopressor use and intensive care unit‐acquired weakness
Authors: Yang Tao , Wang Yan , Xi Xiuming , Yu Shanshan 
Published: September 2024

AbstractObjectiveThis study aims to clarify the uncertain association between vasopressor administration and the development of intensive care unit‐acquired weakness (ICUAW) in critically ill adult patients.MethodsWe conducted a comprehensive search of PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials up to October 10, 2023. Titles and abstracts were independently screened by two authors, who then reviewed full texts and extracted relevant data from the studies that met the inclusion criteria. This review included prospective and retrospective cohort studies that explored the relationship between vasopressor use and ICUAW utilizing univariate or multivariate analysis in adult ICU patients.ResultsA total of 15 studies were included in our review, collectively indicating a statistically significant association between the use of vasopressors and the occurrence of ICUAW (odds ratio [OR], 3.43; 95% confidence intervals [CI], 1.95–6.04), including studies utilizing multivariate analysis (OR, 3.43; 95% CI, 1.76–6.70). Specifically, the use of noradrenaline was significantly associated with ICUAW (OR, 4.42; 95% CI, 1.69–11.56). Subgroup and sensitivity analyses further underscored the significant relationship between vasopressor use and ICUAW, particularly in studies focusing on patients with clinical weakness, varying study designs, different sample sizes, and relatively low risk of bias. However, this association was not observed in studies limited to patients with abnormal electrophysiology.ConclusionsOur review underscores a significant link between the use of vasopressors and the development of ICUAW in critically ill adult patients. This finding helps better identify patients at higher risk of ICUAW and suggests considering targeted therapies to mitigate this risk.
Relationships among tumor necrosis factor‐alpha levels, beta‐amyloid accumulation, and hippocampal atrophy in patients with late‐life major depressive disorder
Authors: Ho Szu‐Kai , Hsiao Ing‐Tsung , Lin Kun‐Ju , Wu Yi‐Ming , Wu Kuan‐Yi 
Published: September 2024

AbstractBackgroundMajor depressive disorder (MDD) is characterized by hippocampal volume reduction, impacting cognitive function. Inflammation, particularly elevated tumor necrosis factor‐alpha (TNF‐α) levels, is consistently implicated in MDD pathophysiology. This study investigates the relationships between TNF‐α levels, hippocampal volume, beta‐amyloid (Aβ) burden, and cognitive abilities in MDD patients, aiming to illuminate the complex interplay among inflammatory markers, pathology indicators, structural brain alterations, and cognitive performance in non‐demented MDD individuals.MethodFifty‐two non‐demented MDD patients, comprising 25 with mild cognitive impairment (MCI), were recruited along with 10 control subjects. Each participant underwent a thorough assessment encompassing TNF‐α blood testing, 18F‐florbetapir positron emission tomography, magnetic resonance imaging scans, and neuropsychological testing. Statistical analyses, adjusted for age and education, were performed to investigate the associations between TNF‐α levels, adjusted hippocampal volume (HVa), global Aβ burden, and cognitive performance.ResultsMCI MDD patients displayed elevated TNF‐α levels and reduced HVa relative to controls. Correlation analyses demonstrated inverse relationships between TNF‐α level and HVa in MCI MDD, all MDD, and all subjects groups. Both TNF‐α level and HVa exhibited significant correlations with processing speed across all MDD and all subjects. Notably, global 18F‐florbetapir standardized uptake value ratio did not exhibit significant correlations with TNF‐α level, HVa, and cognitive measures.ConclusionThis study highlights elevated TNF‐α levels and reduced hippocampal volume in MCI MDD patients, indicating a potential association between peripheral inflammation and structural brain alterations in depression. Furthermore, our results suggest that certain cases of MDD may be affected by non‐amyloid‐mediated process, which impacts their TNF‐α and hippocampal volume. These findings emphasize the importance of further investigating the complex interplay among inflammation, neurodegeneration, and cognitive function in MDD.
Empirical modeling approaches in sustainable supply chain management: A review with bibliometric and network analyses
Authors: Nikseresht Ali , Golmohammadi Davood , Zandieh Mostafa 
Published: September 2024

AbstractThis paper aims to perform a hybrid study with a focus on empirical modeling (EM) and its applications in sustainable supply chain management (SSCM) concepts using bibliometric, network, thematic, and content analyses. The outcomes provide a viewpoint on literature categorization and several innovative insights and perspectives into contemporary research trends in this field. The review is undertaken using 2192 out of more than 24,000 research papers that are extracted and sifted from the Scopus and WoS databases. The results indicate an annual growth rate of 17.65% for the subject under consideration, which holds considerable significance and portends a promising outlook for the field. Seven clusters of papers are identified: (1) SSCM and design using versatile empirical approaches; (2) socially and environmentally responsible SCM and design; (3) new theories and impacts of SSCM integration; (4) data science, predictive analytics, and big data for SC sustainability; (5) closed loop SC roles in bringing sustainability; (6) SSCM during disasters with respect to humanitarian aspects; and (7) linkages between Industry 5.0, digital technologies, circular economy, and SSCM. In this review, fundamental ideas are established, research gaps are identified, and multiple future research subjects are proposed. In addition, important topics are presented for managers and practitioners to consider when adopting EM principles in SSCM. The results contribute to both theoretical and practical management elements and give a solid road map for future study in this sector. This study provides an overview of the evolution of EM and its applications in SSCM concepts; it also particularly elaborates on general pertinent research dimensions, SSCM, sustainability practices, and EM aspects.
Phenolic Compound Profiles, Antioxidant, and Cytoprotective Activity of Elaeagnus conferta Roxb. Fruit
Authors: Lu Jun , Liu Dingli , Cheng Jing , Hu Shende , Yang Zhengyu , Zhang Lin , Ren Jiali 
Published: September 2024

AbstractIn this paper, three varieties of Elaeagnus conferta Roxb fruits prepared by ultrasonic‐assisted extraction from a subtropical region southwest of China were utilized as raw materials to investigate their phenolic profiles, antioxidant activities, and protective effects on injured human umbilical vein endothelial cells (HUVECs). The ultra performance liquid chromatography‐electrospray ionization tandem mass spectrometry (UPLC‐ESI‐MS/MS) findings revealed that fifteen substances, including seven phenolic acids, seven flavonoids, and one gallic acid derivative, were discovered. The dihydromyricetin, ellagic acid, gallic acid were the predominant phenolic compounds in all E.conferta fruits. These E.conferta fruits extracts shown excellent antioxidant activity varied from 2.258±0.03~7.844±0.39 μM Trolox/g and protective effect on HUVECs injured by H2O2 through decrease the level of ROS, MDA, LDH and enhance the SOD level. These finding indicate that E.conferta is a valuable source of high‐capacity antioxidants that might be used as an alternative material for food industries.
In Vitro and In Silico Studies of the Biological Activities of Some Secondary Metabolites Belonging to Ficus sur Forssk (Moraceae): Towards Optimization of Wighteone Metabolite
Authors: Ngoh Misse Mouelle Eitel , Foundikou Nsangou Mohamed , Fofack Hans Merlin Tsahnang , Mboutchak Dieunedort , Koliye Pierre Roger , Amana Ateba Baruch , Ntie‐Kang Fidele , Akone Sergi Herve , Ngeufa Happi Emmanuel 
Published: September 2024

AbstractBased on ethnomedicinal and chemotaxonomic records of Ficus plants, Ficus sur Forssk was studied in the search for bioactive compounds. Eleven known compounds including mixture α ‐amyrin acetate and β ‐amyrin acetate (1 and 2), lupeol (3), 3β‐acetoxy‐olean‐12‐en‐11‐one (4), lupenyl acetate (5), taraxastan‐3,20‐diol (6), 3′‐ (3‐methylbut‐2‐enyl) biochanin A (7), derrone (8), quercetin (9), stigmasterol (10), and stigmasterol glycoside (11) were isolated from stem barks of Ficus sur Forssk. Their structures were obtained through analysis of spectroscopic data 1D and 2D NMR), mass spectrometry, and by comparison of these data with the literature. Nine isolated compounds (1–7, 10, 11) were tested as the active wighteone metabolite previously isolated from the roots of this plant against the human HepG2 hepatocellular carcinoma cells and a small panel of sensitive microbial strains for structure‐ activity relationship purpose. The compounds didn't show any activity. With the aim of understanding the impact of the structural difference between wighteone metabolite and its analogs, the former were cross‐docked to evaluate their anticancer properties via the apoptosis pathway. Wighteone metabolite proved to be the best ligand confirming its previous bioassay result. Thus, the current study lays the framework for the further optimization of wighteone metabolite regarding its anticancer activity.
The Reaction of Fenchone and Camphor Hydrazones with 5‐Acyl‐4‐Pyrones as a Method for the Synthesis of New Polycarbonyl Conjugates: Tautomeric Equilibrium and Antiviral Activity
Authors: Viktorova Viktoria V. , Obydennov Dmitrii L. , Kovaleva Kseniya S. , Yarovaya Olga I. , Khasanov Shokhrukh A. , Bormotov Nikolay I. , Esaulkova Iana L. , Serova Olga A. , Zarubaev Vladimir V. , Shishkina Larisa N. , Salakhutdinov Nariman F. , Sosnovskikh Vyacheslav Y. 
Published: September 2024

AbstractSelective synthesis of polycarbonyl conjugates of (+)‐fenchone and (+)‐camphor was carried out (44–91 % yields) via the ring‐opening transformation of 5‐acyl‐4‐pyrones with hydrazones of the corresponding monoterpenoids. A strong influence of the hydrazone fragment on the observed tautomeric equilibrium of the tricarbonyl system was shown. Although the major tautomer of the conjugates is the acyclic polycarbonyl form, the camphor‐based conjugates undergo new type of ring‐chain tautomerism, diketoenaminone‐dihydropyridone equilibrium, and predominantly exist in the cyclic dihydropyridone form in DMSO‐d6. The polyketones can undergo intramolecular cyclization to form N‐amino‐4‐pyridones in high selectivity. In vitro screening for activity against the influenza virus H1 N1 and vaccinia virus was estimated for the obtained conjugates. The (+)‐fenchone derivatives demonstrated the higher activity against vaccinia virus than camphor derivatives. The conjugate, which was prepared from diethyl isochelidonate and hydrazone (+)‐fenchone, showed the highest activity against vaccinia virus (SI=17).
Recent Progresses in Development of Heterocyclic Compounds for Epilepsy Treatment: Key Research Highlights from 2019–2024
Authors: Singh Preeti , Nisa Kharu , Mavi Renu , Yadav Soni , Kumar Ravi 
Published: September 2024

AbstractEpilepsy which is a chronic neurological disorder is characterized by recurrent seizure poses a significant challenge to healthcare professionals worldwide. Most of antiepileptic drugs have serious side effects that might affect the quality of life such as fatigue, dizziness, weight gain and cognitive impairments. In this context, the search for more effective and potential antiepileptic drug candidate has led to a growing interest in the field of synthesis of heterocyclic compounds. This review will focus on the utilization of heterocyclic moieties including imidazole, indole, thiazole, triazine, quinazoline and oxazole which show remarkable anticonvulsant properties. Furthermore, the exploration of various methodologies for the synthesis of heterocyclic anticonvulsant drugs such as green methodologies and microwave assisted protocols have contributed to the development of environment friendly, more efficient and potential approaches. The review will distinguish from previous ones by specifically focusing on innovative synthetic methodologies, including greener methodologies and micro‐assisted techniques, that contribute to eco‐friendly and environment benign approaches during 2019–2024. In addition to this, the review will focus on the Structure Activity Relationship (SAR) studies of heterocyclic compounds in order to offer insight into the design of next generation antiepileptic drugs with improved efficacy and reduced side effects.
Psychopathy, criminogenic cognitions and emotional responses to affective stimuli among male adult offenders
Authors: Manole Steluța , Enea Violeta 
Published: September 2024

AbstractBackgroundPrevious research has consistently shown value in studying emotion processing with psychopathy, but the relative effect of aural and visual stimulation has hardly been considered.AimsOur aims were to (1) compare reaction time and self‐rated valence ((un)pleasantness), arousal and sense of being dominated by affective sounds or visual images among offenders with and without psychopathy (=/>26) on the psychopathy check‐list revised; (2) investigate any associations, controlling for social desirability and depression; (3) explore the possible mediating effect of criminogenic cognitions on any relationships between psychopathy and emotional responses to affective stimuli.MethodsProfessional educators invited all male offenders serving semi‐open custody sentences in one prison to participate. After a semi structured interview to assess psychopathy, they self‐reported on criminogenic cognition, depression and social desirability scales, before a computer task using standardised human and animal sounds and images. Using the self‐assessment manikin, participants rated the emotional valence, arousal and dominance levels when pleasant, unpleasant and neutral sounds or images were presented.ResultsAbout one in three prisoners completed all the ratings—120 men, of mean age 38.8 years (SD = 11.06). All had shorter reaction times to sounds than images. Offenders with high affective‐interpersonal factor scores rated all types of sounds as less pleasant. Men with high psychopathy scores took longer to respond to unpleasant images than those with lower scores. There was a positive relationship between psychopathy factors and criminogenic cognitions and the external locus of criminogenic cognitions mediated the relationship between psychopathy facets and emotional responses of valence to pleasant sounds.ConclusionOur findings confirm the potential importance of emotional reactions to sounds as well as images among men with psychopathy. Given the shorter reaction times to sounds, in real life sounds could prove more provocative than images. While only small differences emerged between men above and below the PCL‐R threshold, indications from facet analyses suggest that further study of sound stimuli could enhance the understanding of emotional response differences to inform interventions. Future research in this area should focus on human‐related stimuli and add alexithymia measures.
In‐hospital outcomes of ad hoc versus planned PCI for unprotected left‐main disease: An analysis of 8574 cases from British Cardiovascular Intervention Society database 2006–2018
Authors: Kinnaird Tim , Gallagher Sean , Farooq Vasim , Protty Majd B. , Cranch Hannah , Devlin Peader , Sharp Andrew , Curzen Nick , Ludman Peter , Hildick‐Smith David , Johnson Tom , Mamas Mamas A. 
Published: September 2024

AbstractBackgroundAlthough data suggests ad hoc percutaneous coronary intervention (PCI) results in similar patient outcomes compared to planned PCI in nonselected patients, data for ad hoc unprotected left main stem PCI (uLMS‐PCI) are lacking.AimTo determine if in‐hospital outcomes of uLMS‐PCI vary by ad hoc versus planned basis.MethodsData were analyzed from all patients undergoing uLMS‐PCI in the United Kingdom 2006–2018, and patients grouped into uLMS‐PCI undertaken on an ad hoc or a planned basis. Patients who presented with ST‐segment elevation, cardiogenic shock, or with an emergency PCI indication were excluded.ResultsIn total, 8574 uLMS‐PCI procedures were undertaken with 2837 (33.1%) of procedures performed on an ad hoc basis. There was a lower likelihood of intervention for stable angina (28.8% vs. 53.8%, p < 0.001) and a higher rate of potent P2Y12 inhibitor use (16.4% vs. 12.1%, p < 0.001) in the ad hoc PCI group compared to the planned PCI group. Patients undergoing uLMS‐PCI on an ad hoc basis tended to undergo less complex procedures. Acute procedural complications including slow flow (odds ratio [OR]: 1.70, 95% confidence interval [CI]: 1.01–2.86), coronary dissection (OR: 1.41, 95% CI: 1.12–1.77) and shock induction (OR: 2.80, 95% CI: 1.64–4.78) were more likely in the ad hoc PCI group. In‐hospital death (OR: 1.65, 95% CI: 1.19–2.27) and in‐hospital major adverse cardiac or cerebrovascular events (OR: 1.50, 95% CI: 1.13–1.98) occurred more frequently in the ad hoc group. In sensitivity analyses, these observations did not differ when several subgroups were separately examined.ConclusionsAd hoc PCI for uLMS disease is associated with adverse outcomes compared to planned PCI. These data should inform uLMS‐PCI procedural planning.
Ce‐Pr Co‐doped Co3O4 with Enriched Oxygen Vacancies for the Efficient Decomposition of N2O
Authors: Sun Yuxin , Wu Yunshuo , Zhang Zhuoyi , Wu Xuanhao , Wang Haiqiang , Wu Zhongbiao 
Published: September 2024

AbstractNitrous oxide (N2O) has gained increasing attention as a non‐carbon dioxide greenhouse gas, and catalytic decomposition is an effective method for mitigating its emissions. In this study, Ce‐Pr Co‐doped Co3O4 was synthesized via a coprecipitation method and used for the catalytic decomposition of N2O. The experimental results revealed that the N2O decomposition achieved 100% conversion at 400 °C on the catalyst with a Pr/Ce/Co molar ratio of 0.02:0.2:1, exhibiting an 80 °C decrease of T100 compared with that of Co3O4. The introduction of Ce reduced the size and crystallization of Co3O4 particles, increased the activity of the lattice oxygen of Co3O4, and facilitated the formation of oxygen vacancies, thereby enhancing the activation of N2O. However, the introduction of Ce inhibited the crystallization of Co3O4 and the surface coverage of CeO2 decreased the exposure degree of N2O molecules to the Co3O4 surface. Co‐doping strategy of Ce‐Pr was performed to alleviate the negative effects of ceria. Consequently, the incorporation of Ce and Pr species enhanced the redox properties of Co3O4, leading to remarkable catalytic performance of N2O decomposition. This study elucidated the interaction between Ce and Pr dopants and Co3O4, and encouraged more attention on designing novel catalysts for N2O mitigation.
Electrochemical Sensing of Bisphenol A Using Metal Organic Framework/Quantum Dot Composite Modified Gold Electrode
Authors: Oloyede Solomon O. , Ajibade Peter A. 
Published: September 2024

AbstractElectrochemical sensors based on self‐assembled monolayer (SAM) were synthesized using metal‐organic frameworks (MOFs), quantum dots (QDs) and their composite (QDs@MOFs) to modify gold electrode (AuE) that was used as electrochemical sensors for bisphenol A detection. The molecular layer was assembled on the surface of the gold electrode by adsorption and provide a highly flexible method to tailor the interfaces between analyte and the electrode. Single crystal X‐ray of the MOF revealed a six‐coordinate copper(II) ion that bidentately coordinate two molecules of p‐anisic acid and two molecules of 1H‐benzimidazole to form a distorted octahedral geometry around the copper(II) ion. Electrochemical studies revealed that under optimal conditions, the modified gold electrode sensors show excellent sensing of bisphenol A, however, QDs@MOFs modified electrode is the best sensor with the highest oxidation peak current of 8.43E‐05 μA and the lowest charge transfer resistance of 19.4 Ω within a wide concentration range of 0.1–1 μM and a limit of detection (LOD) of 0.252 μM. This could be attributed to the electrocatalytic activity of the composite (QDs@MOFs) modified sensor, and the synergistic effect of the MOFs and QDs in the composite. The LOD is comparable to other electrochemical methods of sensing BPA which indicates that QDs@MOFs modified gold electrode could be develop as sensor for BPA.
Inhibition of Photocatalyst‐Assisted Electron Transfer at ITIES Under Simulated Solar Irradiation‐the Role of Supporting Electrolyte
Authors: Avella Edwin , Folli Andrea , Cuesta Angel 
Published: September 2024

AbstractPhotocatalyst‐assisted charge transfer at the interface between two immiscible electrolyte solutions (ITIES) has been previously proven. However, its practical application requires information on its performance under solar irradiation. We investigated photocatalyst‐assisted oxidation of water at ITIES under solar irradiation using TCNQ 7,7,8,8‐Tetracyanoquinodimethane (TCNQ) as electron scavenger and bis(triphenylphosphoranylidene) ammonium tetrakis(4‐chlorophenyl)borate (BTPPA‐TPBCl) as organic phase electrolyte. No enhancement of water oxidation after assembling photocatalyst nanoparticles at the ITIES was observed. Photocurrents with photocatalyst were similar to those without but in the presence of TCNQ. Photocurrents observed both with and without photocatalyst are shown to be due to photogeneration of TCNQ⋅−, either by reaction with the organic electrolyte or by interfacial oxidation of water. The former dominates at positive potentials and results in a positive photocurrent due to transfer of TCNQ⋅− across the ITIES. The latter dominates at negative potentials and results in a negative photocurrent. Electron paramagnetic resonance (EPR) detected TCNQ⋅− and revealed its stabilisation by formation of an adduct with BTPPA+, which must contribute to making the photoactivity of TCNQ the dominant process even with photocatalyst. These findings highlight the necessity of research on alternative suitable electron scavenger‐supporting electrolyte combinations for implementing ITIES in the photoelectrocatalytic conversion of solar energy.
Recognition‐Encoded Molecules: A Minimal Self‐Replicator
Authors: Rosa‐Gastaldo Daniele , Maria Ara Francesco , Dalla Valle Andrea , Visentin Giulia , Gabrielli Luca 
Published: September 2024

AbstractNucleic acids, with their unique duplex structure, which is key for information replication, have sparked interest in self‐replication's role in life's origins. Early template‐based replicators, initially built on short oligonucleotides, expanded to include peptides and synthetic molecules. We explore here the potential of a class of synthetic duplex‐forming oligoanilines, as self‐replicators. We have recently developed oligoanilines equipped with 2‐trifluoromethylphenol–phosphine oxide H‐bond base pairs and we investigate whether the imine formed between aniline and aldehyde complementary monomers can self‐replicate. Despite lacking a clear sigmoidal kinetic profile, control experiments with a methylated donor and a competitive inhibitor support self‐replication. Further investigations with the reduced aniline dimer demonstrate templated synthesis, revealing a characteristic parabolic growth. After showing sequence selective duplex formation, templated synthesis and the emergence of catalytic function, the self‐replication behaviour further suggests that the unique properties of nucleic acids can be paralleled by synthetic recognition‐encoded molecules.