bluuebunny/crossref_metadata_2025_split huggingface dataset:
Subcellular Optical pH Nanoscale Sensor
Authors: García‐Algar Manuel , Tsoutsi Dionysia , Sanles‐Sobrido Marcos , Cabot Andreu , Izquierdo‐Roca Victor , Gil Habil. Pilar Rivera 
Published: September 2017

AbstractCoated gold nanoparticles bearing a pH‐sensitive molecule serve as nanoscale optical sensors for non‐invasive pH quantification of their endocytosis through surface‐enhanced Raman scattering. Our sensor consists in colloidal gold spheres coated either with (polyethylene glycol) PEG molecules or a silica shell. They carry a sensor molecule that specifically recognize protons. The read out for monitoring changes in the pH is the Raman shift of the sensor molecule that is enhanced on the surface of the plasmonic spheres. Sensing was performed along the way of internalization from the extracellular site through different endo/lysosomal compartments where they are closely packed. The creation of hot spots favored by particle agglomeration inside cells was responsible for the enhancement of changes in signal intensity and was dependent on the surface chemistry. We establish a correlation between the physicochemical properties of the nanoscale sensor (shape, surface chemistry) and its ability to monitor the different pH along its cellular internalization. The PEGylated spheres can sensitively track the pH along their cellular internalization whereas the silica coated ones fail.
A Venture Synthesis and Fabrication of BiVO4 as a Highly Stable Anode Material for Na‐Ion Batteries
Authors: Muruganantham Rasu , Liu Wei‐Ren 
Published: September 2017

AbstractNeedle‐like BiVO4 anode material for Na‐ion batteries was prepared by a simple solvothermal technique at 100 °C without further calcination. The BiVO4 electrode exhibited initial discharge (sodiation) capacity of 897 mAh /g with coulombic efficiency of 70.68% at 100 mA /g. The average coulombic efficiency was estimated at 93.07% and sodiation capacity predicted at 432 mAh/g upto 200 cycles. The average sodiation/desodiation capacity retention were found to be 52.07 and 68.10%, respectively for more than 100 cycles. The results demonstrate that needle‐like BiVO4 anode material offers an excellent electrochemical performance for large‐scale energy storage applications.
Role of Pyridinic Nitrogen on Base Catalyzed Knoevenagel Condensation over Pristine CNx
Authors: Goyal Reena , Sarkar Bipul , Sameer Siddharth , Singhal Nikita , Bordoloi Ankur 
Published: September 2017

AbstractOn a special focus, we have fabricated N2 doped mesoporous ordered CNx material using hexagonal SBA‐15 as hard template through polymerisation of hexamethylene tetramine precurssor. The synthesised materials exhibit a very high specific surface area 1332 cm3/g and pore volume 1.12 cc/g. The HR‐TEM shows the succesful replication of silica template i.e, tubular structure of material. The catlytic activity of material has been tested for Knoevenagel condensation reaction of benzaldehyde and ethyl cyanoacetate. Almost 93 % conversion of benzaldehyde has been achieved within 20 min of reaction at room temperature with ≥99.9 % product selectivity.
A DFT Study of the Conversion of Ptaquiloside, a Bracken Fern Carcinogen, to Pterosin B in Neutral and Acidic Aqueous Medium
Authors: Ríos‐Gutiérrez Mar , Domingo Luis R. , Alonso‐Amelot Miguel E. 
Published: September 2017

AbstractThe conversion of ptaquiloside (PtQ), a bracken fern (Pteridium aquilinum) carcinogen, to pterosin B (PtB), which is involved in the underlying mechanisms of PtQ genotoxicity and carcinogenicity, has been theoretically studied in aqueous neutral (AN) and acid (AA) media, using DFT methods at the PCM(water)‐B3LYP/6‐31G(d)//B3LYP/6‐31G(d) computational level. The β‐elimination of glucose in AN and four reactive channels (A‐D) defined by as many protonation sites in PtQ were calculated. Activation enthalpy decreases (from 42.0 to 12.6 kcal mol−1) in AA relative to AN suggesting protic catalysis. The most favoured channel A started with protonation of the tertiary O15 hydroxyl of PtQ and SN1 water release with strong stabilisation by the spirocyclopropane ring. Natural population analysis and electron localisation function analysis showed significant electron depopulation of vicinal C−C bonds and the remarkable leaving character of the quaternary carbon, which enhanced the nucleophilic attack of water on the distal methylenes while the glucose fragment was retained. This intermediate was unstable, degrading rapidly to a stable PtB‐glucose‐water‐H+ molecular complex whose calculated electronic spectrum (λmax=271.5 nm) matched the value of an intermediate reported earlier with a different structure. PtQ‐dienone, long assumed as the carcinogenic form of PtQ, is not formed in AA but only and unfavourably so in protonated form assisted by one molecule of water.
Versatility of Coordination Modes in Complexes of Monohydroxamic Acids with Half‐Sandwich Type Ruthenium, Rhodium, Osmium and Iridium Cations
Authors: Buglyó Péter , Parajdi‐Losonczi Péter L. , Bényei Attila C. , Lihi Norbert , Bíró Linda , Farkas Etelka 
Published: September 2017

AbstractComplexation of the secondary N‐methyl‐acetohydroxamic acid (HMeaha) with [(η6‐p‐cym)Ru(H2O)3]2+, [(η5‐Cp*)Rh(H2O)3]2+, [(η6‐p‐cym)Os(H2O)3]2+ or [(η5‐Cp*)Ir(H2O)3]2+ cations and the primary acetohydroxamic acid (HAha) with the former two cations (first time in the literature) has been studied in aqueous solution using pH‐potentiometry, NMR, ESI‐MS and DFT calculations. Because the arene or arenyl ligands take three coordination sites of the metal ion, only three remain free for interaction with additional ligand(s). Meaha– forms five‐membered hydroxamate type chelated [ML]+ and [M(OH)L], being the third coordination site occupied by a water molecule in the former complex and by a hydroxide ion in the latter one. While [ML]+ remains predominant even under basic conditions in the Ru‐ and Rh‐containing systems, it is measurable only in slightly acidic region with the two 5d metal ions. Also the tendency for hydrolysis of the aqua ligand in [ML(H2O)]+ complexes follows the trend of the cations for hydrolysis, Os > Ir > Ru > Rh. The X‐ray result did not show any role of the H substituent of Aha– in [{(η5‐Cp*)Rh}2(μ2‐Aha)2]2+, in solution, however, its significant role was supported especially with Ru. All the results support the formation of a stable trinuclear [M3H–2L3(H2O)]+ species in which doubly deprotonated (hydroxymate type) ligands bridge two metal centres by coordinating via the two oxygens to the one cation and via the N‐donor to another one.
The sources of dynamism in dynamic capabilities
Authors: Salvato Carlo , Vassolo Roberto 
Published: September 2017

Research SummaryWe develop a multi‐level theory of dynamic capabilities (DCs) that explains resource dynamics by giving a central role to persons and interpersonal interactions rather than to abstract, firm‐level entities. Our theory integrates the contrasting approaches to DCs in individual‐, interpersonal‐, and organization‐level scholarship. Existing organization‐level approaches portray DCs as collective endeavors but do not specify how they emerge and operate within organizations, while micro‐foundational approaches illuminate actors’ contributions but reduce a firm's DCs to the cognitions and actions of a few top managers. Our integrated theory instead explains DCs as effortful social accomplishments emerging from individual employees’ capacity to leverage interpersonal relationships conducive to productive dialogue. The framework we propose offers new ground for understanding how DCs can be sources of sustainable competitive advantage.Managerial SummaryHow can firms navigate the transformations that relentlessly raise new threats and opportunities in dynamic environments? We suggest that firms develop dynamic capabilities to navigate change when their employees are connected through high‐quality relationships, empowering their innovative potential. Strategic adaptation is possible when people are given the opportunity to act, think, and feel creatively while performing tasks, thus envisioning opportunities to improve how the firm operates. This ability supports sustainable, firm‐level innovation when employees are connected through interpersonal relationships founded on constructive dialogue. Dialogue allows participants to advance and accept proposals for change even in the presence of conflicting interests and viewpoints. Managers may therefore enhance their firm's capacity for change by fostering individual integration and developing contexts that facilitate dialogue and constructive opposition.
Programmable Nucleic Acid Based Polygons with Controlled Neuroimmunomodulatory Properties for Predictive QSAR Modeling
Authors: Johnson Morgan Brittany , Halman Justin R. , Satterwhite Emily , Zakharov Alexey V. , Bui My N. , Benkato Kheiria , Goldsworthy Victoria , Kim Taejin , Hong Enping , Dobrovolskaia Marina A. , Khisamutdinov Emil F. , Marriott Ian , Afonin Kirill A. 
Published: September 2017

AbstractIn the past few years, the study of therapeutic RNA nanotechnology has expanded tremendously to encompass a large group of interdisciplinary sciences. It is now evident that rationally designed programmable RNA nanostructures offer unique advantages in addressing contemporary therapeutic challenges such as distinguishing target cell types and ameliorating disease. However, to maximize the therapeutic benefit of these nanostructures, it is essential to understand the immunostimulatory aptitude of such tools and identify potential complications. This paper presents a set of 16 nanoparticle platforms that are highly configurable. These novel nucleic acid based polygonal platforms are programmed for controllable self‐assembly from RNA and/or DNA strands via canonical Watson–Crick interactions. It is demonstrated that the immunostimulatory properties of these particular designs can be tuned to elicit the desired immune response or lack thereof. To advance the current understanding of the nanoparticle properties that contribute to the observed immunomodulatory activity and establish corresponding designing principles, quantitative structure–activity relationship modeling is conducted. The results demonstrate that molecular weight, together with melting temperature and half‐life, strongly predicts the observed immunomodulatory activity. This framework provides the fundamental guidelines necessary for the development of a new library of nanoparticles with predictable immunomodulatory activity.
S‐Doped TiSe2 Nanoplates/Fe3O4 Nanoparticles Heterostructure
Authors: Yang Jun , Zhang Yufei , Zhang Yizhou , Shao Jinjun , Geng Hongbo , Zhang Yu , Zheng Yun , Ulaganathan Mani , Dai Zhengfei , Li Bing , Zong Yun , Dong Xiaochen , Yan Qingyu , Huang Wei 
Published: September 2017

Abstract2D Sulfur‐doped TiSe2/Fe3O4 (named as S‐TiSe2/Fe3O4) heterostructures are synthesized successfully based on a facile oil phase process. The Fe3O4 nanoparticles, with an average size of 8 nm, grow uniformly on the surface of S‐doped TiSe2 (named as S‐TiSe2) nanoplates (300 nm in diameter and 15 nm in thickness). These heterostructures combine the advantages of both S‐TiSe2 with good electrical conductivity and Fe3O4 with high theoretical Li storage capacity. As demonstrated potential applications for energy storage, the S‐TiSe2/Fe3O4 heterostructures possess high reversible capacities (707.4 mAh g−1 at 0.1 A g−1 during the 100th cycle), excellent cycling stability (432.3 mAh g−1 after 200 cycles at 5 A g−1), and good rate capability (e.g., 301.7 mAh g−1 at 20 A g−1) in lithium‐ion batteries. As for sodium‐ion batteries, the S‐TiSe2/Fe3O4 heterostructures also maintain reversible capacities of 402.3 mAh g−1 at 0.1 A g−1 after 100 cycles, and a high rate capacity of 203.3 mAh g−1 at 4 A g−1.
Designed Microdevices for In Vitro Diagnostics
Authors: Sun Xuming , Wan Jing jing , Qian Kun 
Published: September 2017

AbstractIn vitro diagnostics (IVD) refers to in vitro tests of biological specimens and contributes to two‐thirds of clinical diagnosis. There are two major components to consider for the construction of devices for IVD, including: i) capture and recognition; and ii) detection methods. Herein, the principle, design, and application of microdevices regarding these two routes in recent progress for IVD are shown. Microarrays, microfluidics, and nanodevices are reviewed for capture and recognition. Mass spectrometry, fluorescence, electrochemistry, and so on are summarized as detection methods. The roles of materials in devices toward diverse applications are elucidated with the aims of designing materials for high‐performance device toward precision medicine and initiating the development of advanced diagnostic tools involving various biomarkers.
Progress in the Development of Sodium‐Ion Solid Electrolytes
Authors: Kim Jung‐Joon , Yoon Kyungho , Park Inchul , Kang Kisuk 
Published: September 2017

AbstractThe development of safe, reliable, yet economical energy storage has been reemphasized with recent incidents involving the explosion and subsequent recall of lithium‐ion batteries. The organic liquid electrolyte used in the conventional lithium‐ion battery can potentially act as a fuel for combustion in a thermal‐runaway reaction, and hence an alternative with a significantly reduced flammability must be sought. All‐solid‐state batteries have the potential to meet safety and reliability requirements with the possibility of increasing the volumetric energy density of the system, making these a promising candidate for the development of the next generation of energy storage. Moreover, the sodium‐ion battery exhibits a better cost‐efficiency without significantly compromising the energy density, making the combination of the sodium chemistry with the solid electrolyte an attractive choice for safe and economical energy storage. Here, a general background on the recent development of ceramic and glass‐ceramic sodium‐ion‐conducting electrolytes is provided with regard to oxide‐, sulfide‐, and hydride‐based electrolytes. The ionic conductivity, chemical stability, and mechanical properties of the sodium‐based solid electrolyte are discussed, which is followed by a perspective on future developments in the field.
Epilogue: Beyond 1992
Authors: Gunneriusson Håkan 
Published: September 2017

Abstract
The empirical example was to show just the initial years of the war, but a few things can be said of the last years of the war, without being conclusive on the matter. As war went on the violence escalated and the escalation gave way for even more violence. The logic of practice continued to change as the structuring field continued to be restructured. Without going into details it is worth mentioning that Milošević, who already had lost Serbian support, lost even more as he tried to balance between the international and national arenas at the same time. At the same time less international prolific actors could go full out on the national arena in support of Serbian interest.
Carcinoma in the Remnant Stomach During Long‐Term Follow‐up After Distal Gastrectomy for Gastric Cancer: Analysis of Cumulative Incidence and Associated Risk Factors
Authors: Hanyu Takaaki , Wakai Atsuhiro , Ishikawa Takashi , Ichikawa Hiroshi , Kameyama Hitoshi , Wakai Toshifumi 
Published: September 2017

AbstractBackgroundThe number of patients with remnant gastric cancer following resection of gastric cancer may increase. The aims of this study were to investigate the development of remnant gastric cancer after distal gastrectomy for gastric cancer and to examine its cumulative incidence, clinicopathological characteristics, and risk factors.MethodsWe examined 437 patients with relapse‐free survival for 5 years or more after distal gastrectomy with Billroth I reconstruction for gastric cancer performed between 1985 and 2005.ResultsA total of 17 patients suffered from remnant gastric cancer. The cumulative incidence was 3.7% at 10 years and 5.4% at 20 years. The median time until development of remnant gastric cancer was 79 months (range 30–209 months). The presence of synchronous multiple gastric cancers was a significant independent risk factor for remnant gastric cancer (hazard ratio 4.036; 95% confidence interval 1.478–11.02; P = 0.006). Of the 17 patients, the 13 whose remnant gastric cancer was detected via regular endoscopy showed better prognoses than the patients detected by other means (P < 0.001).ConclusionThe cumulative incidence of remnant gastric cancer was 5.4% at 20 years. In particular, patients who had multiple gastric cancers at initial gastrectomy were at higher risk for remnant gastric cancer. Therefore, long‐term endoscopic surveillance is important.
Impact of Splenic Volume and Splenectomy on Prognosis of Hepatocellular Carcinoma Within Milan Criteria After Curative Hepatectomy
Authors: Takeishi Kazuki , Kawanaka Hirofumi , Itoh Shinji , Harimoto Norifumi , Ikegami Toru , Yoshizumi Tomoharu , Shirabe Ken , Maehara Yoshihiko 
Published: September 2017

AbstractBackgroundThe prognosis of hepatocellular carcinoma (HCC) with portal hypertension (PH) is very poor. Splenomegaly is considered important evidence of PH. Our aim was to clarify the prognostic value of splenic volume (SV) and the effect of splenectomy on the prognosis of HCC within the Milan criteria after curative hepatectomy.MethodsIn this single‐center retrospective study, we reviewed 160 patients with HCC that met the Milan criteria, including 138 who had undergone hepatectomy and 22 who had undergone hepatectomy and splenectomy between July 2004 and December 2010. SV was measured by three‐dimensional computed tomography and patients allocated to three groups (high SV ≥300 mL; low <300 mL; and splenectomy) to compare post‐hepatectomy survival rates.ResultsMultivariate analyses showed that SV is an independent prognostic factor for overall and disease‐free survival. The overall survival rates at 5 years in the high SV, low SV, and splenectomy groups were 39, 75, and 88%, respectively. The overall survival rate in the high SV group was significantly worse than in the low SV and splenectomy groups (P < 0.001). There was no significant difference between the low SV and splenectomy groups (P = 0.831).ConclusionsHigh SV is an independent predictor of post‐hepatectomy HCC recurrence and overall survival. There is no significant difference in prognosis between low SV and splenectomy groups, even though the latter had high SV. Combined splenectomy with hepatectomy for HCC and PH may improve prognosis and be an appropriate alternative when liver transplantation cannot be performed.
Optimization of an Aqueous Extraction Process for Pomegranate Seed Oil
Authors: Ghorbanzadeh Ramin , Rezaei Karamatollah 
Published: September 2017

AbstractResponse surface methodology employing a five‐level, four‐variable central composite rotatable design was applied to study the effects of extraction time, extraction temperature, pH and water/solid ratio on the extraction yield of pomegranate seed oil using an aqueous extraction approach. In addition, quality indices, fatty acid composition and antioxidant activity of the obtained oil were studied and compared with those of typical hexane‐, cold press‐ and hot press‐extracted oil. Aqueous extraction resulted in the maximum oil recovery of 19.3% (w/w), obtained under the following critical values: water/solid ratio (2.2:1.0, mL/g), pH 5.0, extraction temperature = 63 °C and extraction time = 375 min. This yield is lower than that obtained via hexane extraction (26.8%, w/w) and higher than the yields from cold press (7.0%, w/w) and hot press (8.6%, w/w) extraction. A comparison of the characteristics of the oils based on extraction method revealed that the unsaturated fatty acid content was highest for the oil obtained by aqueous extraction. In addition, higher levels of iodine and peroxide and lower levels of acid, p‐anisidine and unsaponifiable matter were observed. The oil obtained with aqueous extraction also exhibited higher antioxidant activity than oils obtained by hexane or hot press extraction.
Archaeological Aerial Thermography in Theory and Practice
Authors: Casana Jesse , Wiewel Adam , Cool Autumn , Hill Austin Chad , Fisher Kevin D. , Laugier Elise J. 
Published: September 2017

ABSTRACTWhile a long history of experimental data shows that aerial thermal images can reveal a wide range of both surface and subsurface archaeological features, technological hurdles have largely prevented more widespread use of this promising prospecting method. However, recent advances in the sophistication of thermal cameras, the reliability of commercial drones, and the growing power of photogrammetric software packages are revolutionizing archaeologists' ability to collect, process, and analyze aerial thermal imagery. This paper provides an overview of the theory behind aerial thermography in archaeology, as well as a discussion of an emerging set of methods developed by the authors for undertaking successful surveys. Summarizing investigations at archaeological sites in North America, the Mediterranean, and the Near East, our results illustrate some contexts in which aerial thermography is very effective, as well as cases in which ground cover, soil composition, or the depth and character of archaeological features present challenges. In addition, we highlight novel approaches for filtering out noise caused by vegetation, as well as methods for improving feature visibility using radiometric thermal imagery.
Intentional overdose of the novel anti-epileptic drug eslicarbazepine presenting with recurrent seizures and ventricular dysrhythmias
Authors: Thompson Jesse , Powell James D. , Ovakim Daniel H. 
Published: September 2017

AbstractEslicarbazepine is a novel anti-epileptic agent indicated for the treatment of partial-onset seizures. We present the case of an 18 year old female that presented to the Emergency Department four hours after a reported intentional ingestion of an estimated 5600 mg of eslicarbazepine. Although initially hemodynamically stable and neurologically normal, shortly after arrival she developed confusion, rigidity and clonus, followed by recurrent seizures, hypoxemia and cardiac arrest which responded to cardiopulmonary resuscitation and wide complex tachycardia requiring defibrillation. Treatment for refractory seizures included benzodiazepines and eventual intubation and sedation with propofol. Cardiac toxicity responded to sodium bicarbonate. In addition, empiric hemodialysis was performed. In this case report, we discuss the successful management of the first reported overdose of eslicarbazepine using supportive care and hemodialysis.
The Forgotten Need of Disaster Relief
Authors: Tamariz Leonardo , Cely Cynthia , Palacio Ana 
Published: September 2017

AbstractDisasters in countries with limited resources can put the emergency preparedness of the country to the test. The first major task after a disaster is to take care of the wounded. In countries where the epidemiological transition has occurred, chronic disease can place a major strain on public health preparedness after a disaster. The purpose of this field report is to alert public health practitioners of an infrequently reported public health problem: the impact of natural disasters on adherence to chronic medications. In our experience, the most common complaint in the weeks that followed the 2016 earthquake was not having access to their chronic medications. (Disaster Med Public Health Preparedness. 2018; 12: 291–295)