bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent Changes in the Moisture Source of Precipitation over the Tibetan Plateau
Authors: Zhang Chi , Tang Qiuhong , Chen Deliang 
Published: November 2016

Abstract
Evidence has suggested a wetting trend over part of the Tibetan Plateau (TP) in recent decades, although there are large uncertainties in this trend due to sparse observations. Examining the change in the moisture source for precipitation over a region in the TP with the most obvious increasing precipitation trend may help understand the precipitation change. This study applied the modified Water Accounting Model with two atmospheric reanalyses, ground-observed precipitation, and evaporation from a land surface model to investigate the change in moisture source of the precipitation over the targeted region. The study estimated that on average more than 69% and more than 21% of the moisture supply to precipitation over the targeted region came from land and ocean, respectively. The moisture transports from the west of the TP by the westerlies and from the southwest by the Indian summer monsoon likely contributed the most to precipitation over the targeted region. The moisture from inside the region may have contributed about 18% of the total precipitation. Most of the increased moisture supply to the precipitation during 1979–2013 was attributed to the enhanced influx from the southwest and the local moisture supply. The precipitation recycling ratio over the targeted region increased significantly, suggesting an intensified hydrological cycle. Further analysis at monthly scale and with wet–dry-year composites indicates that the increased moisture contribution was mainly from the southwest and the targeted region during May and September. The enhanced water vapor transport from the Indian Ocean during July and September and the intensified local hydrological recycling seem to be the primary reasons behind the recent precipitation increase over the targeted region.
A Multisystem View of Wintertime NAO Seasonal Predictions
Authors: Athanasiadis Panos J. , Bellucci Alessio , Scaife Adam A. , Hermanson Leon , Materia Stefano , Sanna Antonella , Borrelli Andrea , MacLachlan Craig , Gualdi Silvio 
Published: November 2016

Abstract
Significant predictive skill for the mean winter North Atlantic Oscillation (NAO) and Arctic Oscillation (AO) has been recently reported for a number of different seasonal forecasting systems. These findings are important in exploring the predictability of the natural system, but they are also important from a socioeconomic point of view, since the ability to predict the wintertime atmospheric circulation anomalies over the North Atlantic well ahead in time will have significant benefits for North American and European countries.
In contrast to the tropics, for the mid latitudes the predictive skill of many forecasting systems at the seasonal time scale has been shown to be low to moderate. The recent findings are promising in this regard, suggesting that better forecasts are possible, provided that key components of the climate system are initialized realistically and the coupled models are able to simulate adequately the dominant processes and teleconnections associated with low-frequency variability. It is shown that a multisystem approach has unprecedented high predictive skill for the NAO and AO, probably largely due to increasing the ensemble size and partly due to increasing model diversity.
Predicting successfully the winter mean NAO does not ensure that the respective climate anomalies are also well predicted. The NAO has a strong impact on Europe and North America, yet it only explains part of the interannual and low-frequency variability over these areas. Here it is shown with a number of different diagnostics that the high predictive skill for the NAO/AO indeed translates to more accurate predictions of temperature, surface pressure, and precipitation in the areas of influence of this teleconnection.
Characterizing the Effect of Vegetation Dynamics on the Bulk Heat Transfer Coefficient to Improve Variational Estimation of Surface Turbulent Fluxes
Authors: Abdolghafoorian Abedeh , Farhadi Leila , Bateni Sayed M. , Margulis Steve , Xu Tongren 
Published: November 2016

Abstract
Estimation of turbulent heat fluxes by assimilating sequences of land surface temperature (LST) observations into a variational data assimilation (VDA) framework has been the subject of numerous studies. The VDA approaches are focused on the estimation of two key parameters that regulate the partitioning of available energy between sensible and latent heat fluxes. These parameters are neutral bulk heat transfer coefficient CHN and evaporative fraction (EF). The CHN mainly depends on the roughness of the surface and varies on the time scale of changing vegetation phenology. The existing VDA methods assumed that the variations in vegetation phenology over the period of one month are negligible and took CHN as a monthly constant parameter. However, during the growing season, bare soil may turn into a fully vegetated surface within a few weeks. Thus, assuming a constant CHN may result in a significant error in the estimation of surface fluxes, especially in regions with a high temporal variation in vegetation cover. In this study the VDA approach is advanced by taking CHN as a function of leaf area index (LAI). This allows the characterization of the dynamic effect of vegetation phenology on CHN. The performance of the new VDA model is tested over three sites in the United States and one site in China. The results show that the new model outperforms the previous one and reduces the root-mean-square error (and bias) in sensible and latent heat flux estimates across the four sites on average by 31% (61%) and 21% (37%), respectively.
Effect of the systemic inflammatory response, as provoked by elective orthopaedic surgery, on HbA1c
Authors: Chadburn Andrew J , Garman Elizabeth , Abbas Raad , Modupe Anu , Ford Clare , Thomas Osmond L , Chugh Sanjiv , Deshpande Shreeram , Gama Rousseau 
Published: November 2016

Background In acutely ill patients with new onset hyperglycaemia, plasma glucose cannot reliably distinguish between stress hyperglycaemia and undiagnosed diabetes mellitus. We, therefore, investigated the diagnostic reliability of glycated haemoglobin (HbA1c) in acute illness by prospectively evaluating the effect of the systemic inflammatory response, as provoked by elective orthopaedic surgery, on HbA1c. Methods HbA1c and serum C-reactive protein concentrations were compared before and two days after elective knee or hip surgery in 30 patients without diabetes. C-reactive protein was used to assess the systemic inflammatory response. Results The mean (standard deviation) serum C-reactive protein increased following surgery (4.8 [7.5] vs. 179.7 [61.9] mg/L; P<0.0001). HbA1c was similar before and after surgery (39.2 [5.4] vs. 38.1 [5.1] mmol/moL, respectively; P = 0.4363). Conclusions HbA1c is unaffected within two days of a systemic inflammatory response as provoked by elective orthopaedic surgery. This suggests that HbA1c may be able to differentiate newly presenting type 2 diabetes mellitus from stress hyperglycaemia in acutely ill patients with new onset hyperglycaemia.
The role of epigenetics in social psychiatry
Authors: Peedicayil Jacob 
Published: November 2016

Background: Epigenetics refers to the study of heritable changes in gene expression not involving changes in DNA sequence and is presently an active area of research in biology and medicine. There is increasing evidence that epigenetics is involved in the pathogenesis of psychiatric disorders. Aims and Methods: Several studies conducted to date have suggested that psychosocial factors act by modifying epigenetic mechanisms of gene expression in the brain in the pathogenesis of psychiatric disorders. Such studies have been conducted both on brain tissues and also using peripheral tissues as substitutes for brain tissues. This article reviews such studies. Results and Conclusion: Epigenetic mechanisms of gene expression in the brain appear to link one individual with another in the context of social psychiatry. Epigenetics appears to be of major importance to the field of social psychiatry.
Differential impacts of social support on mental health: A comparison study of Chinese rural-to-urban migrant adolescents and their urban counterparts in Beijing, China
Authors: Zhuang Xiao Yu , Wong Daniel Fu Keung 
Published: November 2016

Background: The number of internal migrant children in China has reached 35.8 million by the end of 2010. Previous studies revealed inconsistent findings regarding the mental health status of rural-to-urban migrant adolescents, as well as the impact of peer, teacher and parental support on the mental health of Chinese adolescent migrants. Aims: Using a comparative approach, this study attempted to compare the mental health status between migrant and urban-born adolescents and to clarify the specific roles of different sources of social support in the mental health of migrant and urban adolescents. Method: A cross-sectional survey using a cluster convenience sampling strategy was performed in Beijing, China. A structured questionnaire was filled out by 368 rural-to-urban migrant adolescents and 325 urban-born adolescents. Results: A significant difference was found only for positive affect (PA) but not for negative affect (NA) between the two groups, favouring the urban-born adolescents. Social support from all the three sources were all predictive of PA among rural-to-urban migrant adolescents, while only peer support contributed to PA among urban-born adolescents. Unexpectedly, teachers’ support contributed to an increase in NA among urban-born adolescents. Conclusion: The findings contribute to understanding of the mental health status of migrant adolescents in China and the differential impact of the various sources of social support on migrant and urban-born adolescents. Also the findings may inform the development of mental health services and programmes that can potentially benefit a large number of internal migrant adolescents in China.
Eye trauma in Laurel and Hardy movies – another nice mess
Authors: Zegers Lara DA , Zegers Richard HC 
Published: November 2016

Background and aims One of the characteristics in Laurel and Hardy films is a lot of physical violence. The present study examines the occurrence of eye trauma in Laurel and Hardy movies and discusses the impact they could have been had if the films were set in reality. Methods and results All 92 movies starring Laurel and Hardy as a pair in leading roles were watched together by the authors and were scored for any eye trauma. Eighty-eight eye traumas happened, of which 48% were directed at Hardy. The eye poke was the most frequently occurring eye trauma and the traumatic corneal abrasion was very likely the most frequently occurring injury. Among the most serious causes of eye trauma were the pin of a door handle, a stick, a champagne cork, a tree branch and tacks. Conclusion Without a doubt, if their films had been reality, especially Hardy but also Laurel and several other people, would have suffered from serious eye injuries caused by the 88 eye traumas. The findings of the present study might reflect the personality, character and intellectual capacity of both Laurel and Hardy as ‘Two Minds Without a Single Thought’.
Normal testes asymmetry evaluated by apparent diffusion coefficient and magnetization transfer ratio
Authors: Tsili Athina C , Ntorkou Alexandra , Giannakis Dimitrios , Sofikitis Nikolaos , Argyropoulou Maria I 
Published: November 2016

Background In humans, the left testis generally hangs lower than the right and the right is larger than the left. Magnetic resonance imaging (MRI) represents an important adjuvant modality in the investigation of testicular diseases. Purpose To assess if normal testes asymmetry is related to apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR). Material and Methods The normal testes from 106 men were included. Testicular volume (TV) was calculated by using the ellipsoid formula: length × width × height × 0.52. Diffusion-weighted imaging was performed using a SS EPI diffusion pulse sequence and b-values of 0 and 900 s/mm−2. Magnetization transfer imaging was obtained using a 3D GRE sequence both with and without an off-resonance radiofrequency pulse. MTR maps were obtained by the following formula: (SIo–SIm) / (SIo) × 100%, where SIo and SIm represent the signal intensity in the baseline image and that in the corresponding image acquired with an off-resonance MT pulse, respectively. The mean and standard deviation of testicular volume (TV), ADC, and MTR of both testes was calculated and compared using a paired sample t-test. Results The mean TV (mL) was greater ( P = 0.006) for the right testis (16.77 ± 4.84) compared to the left (15.97 ± 4.45). ADC of the right testis (1.09 ± 0.12 × 10 − 3 mm2 s−1) was not different ( P = 0.064) from that of the left testis (1.07 ± 0.12 × 10−3 mm2 s−1). Differences ( P = 0.032) were observed between MTR of the right (46.6 ± 2.1%) and left testis (46.0 ± 2.2%). Conclusion The reported differences in paired testes size was confirmed, introducing a possible relationship with structural and functional asymmetry of normal testes, based on MTR.
Efficacy of triamcinolone acetate and methylprednisolone acetonide for intrabursal injection after ultrasound-guided percutaneous treatment in painful shoulder calcific tendonitis: a randomized controlled trial
Authors: Battaglia Milva , Guaraldi Federica , Gori Davide , Castiello Emanuela , Arvat Emanuela , Sudanese Alessandra 
Published: November 2016

Background Ultrasound-guided percutaneous irrigation of calcific tendinopathy (US-PICT) with intrabursal steroid injection is an elective treatment for painful rotator cuff calcific tendinopathy. Purpose To compare the efficacy of post-US-PICT intrabursal 40 mg injection of triamcinolone acetonide (TA) versus methylprednisolone acetate (MA). Material and Methods Forty patients (22 women; mean age 48.7 ± 7.2 years) with painful shoulder calcific tendinopathy, treated with TA or MA injected intrabursally after US-PICT, were included in this randomized controlled trial. At baseline and after 1, 7, 15, 30, 45, and 180 days, patients underwent US and clinical examination, using Constant (CS) and VAS (VS) scores. Complications and analgesic use were also recorded. Results Compared to baseline, at the 45-day follow-up, TA and MA group showed a similar improvement (Δ) in CS (42 ± 10 versus 36 ± 9 points) and VS (−4.4 ± 1.3 versus −3.6 ± 1.3 points). At the 180-day follow-up, the improvement was higher in TA versus MA (ΔCS: 53 ± 7 versus 44 ± 7 points; ΔVS: −4.9 ± 1.1 versus −3.9 ± 1 points). Multivariate analysis showed a mean CS higher ( P = 0.02) in TA versus MA group, while VS was similar. TA had a 5 × higher ( P = 0.007) chance of reaching complete remission (CS = 100 points) than MA group. A progressive decrease in analgesic use, concomitant to a significant and similar reduction of bursitis and calcifications, was observed in both groups. No major complications occurred. Conclusion Two-needle US-PICT with intrabursal steroid injection is safe and effective. The chance of reaching better scores and, even more important for a clinical perspective, of functional recovery, is higher in patients treated with TA than MA.
Tubal patency during the menstrual cycle and during treatment with hormonal contraceptives: a pilot study in women
Authors: Jensen Jeffrey T , Patil Eva , Seguin Jacqueline , Thurmond Amy 
Published: November 2016

Background Hysterosalpingram (HSG) evaluation of tubal patency is typically performed in the follicular phase, but data to support this timing are lacking. Purpose To determine whether menstrual cycle phase or hormonal treatments affect observation of tubal patency during HSG. Material and Methods Ten participants underwent repeated HSG examinations: during the follicular and luteal phase of a natural menstrual cycle; 30 days following continuous administration of a combined oral contraceptive (COC); and 30 days after an intramuscular injection of depo medroxyprogesterone (DMPA) acetate. Participants with tubal blockade following DMPA had a fifth HSG 30 days following a second course of COCs. The primary outcome was tubal patency. Results All 10 participants demonstrated bilateral tubal patency (BTP) on at least one HSG examination during the study. One participant showed bilateral functional occlusion (FO) during the follicular phase examination, but BTP with the luteal phase, COC cycle, and DMPA exams. One participant with BTP discontinued participation and nine completed the COC HSG exam with BTP in seven, and one each with bilateral or unilateral FO. Seven participants completed the DMPA HSG with BTP in six and unilateral FO in one; BTP was seen in the final HSG after restarting the COC. Conclusion This pilot study supports the luteal phase of natural cycles as the optimum time for evaluation of tubal patency. The occurrence of functional occlusion of the fallopian tube on HSG examination performed during the follicular phase and following contraceptive steroid treatment supports a role of hormonal action on the utero-tubal junction.
Effects of thyroid hormone withdrawal on metabolic and cardiovascular parameters during radioactive iodine therapy in differentiated thyroid cancer
Authors: An Jee Hyun , Song Kee-Ho , Kim Dong-Lim , Kim Suk Kyeong 
Published: November 2016

Objective To investigate the cardiometabolic effects of a severe hypothyroid state induced by withdrawal of thyroid hormone replacement before radioactive iodine therapy. Methods Patients with thyroid cancer who were scheduled to receive radioactive iodine ablation were enrolled. Cardiometabolic parameters were measured using blood samples taken immediately before levothyroxine withdrawal, 4 weeks following withdrawal (on radiotherapy day), and 4 weeks following reinstitution of levothyroxine. Results Out of 48 patients (age 49.4 ± 10.5 years; 77.1% [37/48] female), the severe hypothyroid state induced by levothyroxine withdrawal significantly aggravated the majority of lipid parameters, particularly in patients with a greater number of metabolic syndrome components. Fasting plasma glucose levels and homeostatic model assessment values for insulin resistance and β-cell function significantly decreased following levothyroxine withdrawal. Serum high-sensitivity C-reactive protein, fibrinogen and cystatin C levels significantly decreased, and homocysteine levels increased during the severe hypothyroid state. All of these changes were reversed by levothyroxine reinstitution. Conclusions Severe hypothyroid state induced pronounced changes in cardiometabolic parameters. Further studies should identify the long-term effects of changes in these parameters on cardiovascular morbidity and mortality in relation to thyroid disease.
SERPINE1 -844 and -675 polymorphisms and chronic obstructive pulmonary disease in a Chinese Han population
Authors: Xu Xia , Wang Hongchao , Li Haijun , Cui Xiaopei , Zhang Hongyu 
Published: November 2016

Objective To investigate the association between serpin family E member 1 ( SERPINE1) -844 A/G and -675 4G/5G polymorphisms and chronic obstructive pulmonary disease (COPD) in a Chinese Han population. Method SERPINE1 -844 A/G and -675 4G/5G polymorphisms were assessed by polymerase chain reaction-restriction fragment length polymorphism sequencing of genomic DNA from patients with COPD and healthy smoking controls. Results Out of 140 patients with COPD and 100 controls, all SERPINE1 -844 and -675 polymorphisms were in Hardy-Weinberg equilibrium. Differences in SERPINE1 -675 4G and 5G allele frequencies were statistically significant between the COPD and control groups (odds ratio [OR] 1.45, 95% confidence interval [CI] 1.00, 2.09), but there was no significant between-group difference in SERPINE1 -844 A and G allele frequencies. The SERPINE1 -675 4G/4G genotype was associated with COPD (OR 1.87, 95% CI 1.06, 3.32 [binary logistic regression]). Haplotype analysis showed that COPD was associated with SERPINE1 -844G/4G (OR 2.11, 95% CI 1.32, 3.38) and SERPINE1 -844G/5G (OR 0.66, 95% CI 0.45, 0.95). Conclusion The SERPINE1 -675 polymorphism, but not SERPINE1 -844 polymorphism, was associated with susceptibility to COPD in a Chinese Han population.
Taccaoside induces apoptosis in hepatocellular carcinoma cell lines
Authors: Sun Yuewen , Qiu Hanchen , Ou Mingchun , Chen Runli , Liang Gang 
Published: November 2016

Objective Taccaoside, a steroidal saponin, has been shown to be cytotoxic, although the mechanism of cytotoxicity remains unclear. This study examined the effect of taccaoside on the human hepatocellular carcinoma (HCC) cell lines SMMC-7721 and Bel-7404. Methods The antiproliferative effect of taccaoside were measured using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay. Cells were stained with Hoechst 33258 to observe morphology. Cell cycle and apoptosis were analysed by flow cytometry. Caspase activation was detected using specific assays, and PARP, Bax and Bcl-2 expression were analysed using western blotting. Results Taccaoside showed antiproliferative effect on HCC cell lines growth in a concentration- and time-dependent manner. Taccaoside arrested cell cycle in the G2/M phase and induced caspase-dependent apoptosis. Western blotting indicated that taccaoside upregulated Bax expression and downregulated Bcl-2 expression. PARP cleavage was observed following taccaoside treatment. Conclusions This study showed that taccaoside may inhibit HCC cell proliferation by inducing apoptosis.
Magnetic resonance imaging investigation of radio-lunate relations: use in assessing distal radial fracture reduction
Authors: Medlock G. , Wohlgemut J. M. , Stevenson I. M. , Johnstone A. J. 
Published: November 2016

Reformatted magnetic resonance imaging scans of 27 normal wrists were examined in incremental degrees of rotation around the central axis of the radial shaft to 30° in both directions from true lateral. A line was superimposed on the outer border of the radial dorsal cortex and continued distally to the carpal region. Measurements were made from the superior pole of the lunate to this line. This distance did not change significantly with rotation. This allows a quick and accurate way of assessing distal radial fracture reduction from poorly taken lateral radiographs. In addition, the relevant landmarks are not obscured by implants or casts. Level of evidence: III, diagnostic study
Pelvic-Spinal Analysis and the Impact of Onabotulinum toxin A Injections on Spinal Balance in one Child With Cerebral Palsy
Authors: Chaléat-Valayer Emmanuelle , Bernard Jean-Claude , Deceuninck Julie , Roussouly Pierre 
Published: November 2016

Background: In children with cerebral palsy, primary (eg, abnormal muscle tone and weakness) and secondary impairments (eg, contractures) can modify pelvic-spinal alignment. The main aim of this article was to establish a new approach to pelvic-spinal analysis in children with cerebral palsy, taking into account the whole pelvis-spine complex, illustrated by a case study. Methods: This is a case study of an ambulatory child with cerebral palsy (spastic diplegia) who underwent analysis of the pelvic-spine complex from X-ray images taken in standing position from C2 to the proximal femur. Pelvic shape was characterized by the pelvic incidence angle, which is the sum of sacral slope and pelvic tilt, before and after the treatment by regular onabotulinumtoxinA injections into the hip flexors, and the use of soft lumbar brace over 5 years. Results: The sagittal balance of the spine was improved following the treatment, with a reduction in lumbar lordosis and sacral slope. The reduction in lumbar hyperextension likely reduced the risk of spondylolysis, low back pain, and degenerative spondylolisthesis in adulthood. Conclusion: A biomechanical approach to the evaluation of the pelvic-spinal complex offers new perspectives to increase the understanding of spinal balance in children with cerebral palsy, providing more options for treatment, such as onabotulinumtoxinA.