bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pollution source characterization and evaluation of groundwater quality utilizing an integrated approach of Water Quality Index, GIS and multivariate statistical analysis
Authors: Kumar Amit , Singh Anshuman 
Published: September 2024

ABSTRACTThe Mid-Gangetic Plain, a vital farmland in India, faces increasing groundwater quality deterioration due to anthropogenic activities. This study aimed to assess groundwater quality and contamination sources in the region utilizing statistical methods. A total of 78 groundwater samples were collected and analyzed using standard methods. The hydrochemistry analysis of samples revealed that several parameters such as Ca2+, Mg2+, HCO3−, NO3−, F− and PO43− surpassed the limits prescribed by the Bureau of Indian Standards (BIS). The principal component analysis yielded three significant factors, explaining 68.96% variation, highlighting geogenic and anthropogenic influences on groundwater chemistry. Hierarchical cluster analysis categorized groundwater into three clusters based on the parameters with similar trends of variation. Furthermore, discriminant analysis identified four significant variables (Mg2+, F−, Cl− and NO3−) responsible for creating the distinction among the identified clusters. Hydrogeochemical categorization and multivariate statistical analyses indicated that rock–water interaction, weathering, leaching and anthropogenic activities collectively influenced groundwater quality throughout the studied region. The Water Quality Index reveals that 59% of samples have good water quality, while 41% exhibit poor quality predominantly concentrated in the south-western, south-eastern and central regions. This study demonstrates the efficacy of statistical techniques to interpret complex datasets and grasp water quality dynamics, enhancing groundwater management.
Inhibition of Colorectal Cancer Metastasis by Total Flavones of Abelmoschus manihot via LncRNA AL137782-mediated STAT3/EMT Pathway Regulation
Authors: Li Qian , Zhang Hui , He Yongshan , Zhang Hao , Han Conghui 
Published: September 2024

Background:
Colorectal cancer (CRC) ranks among the most lethal malignancies globally, particularly
following metastasis which results in poor prognosis. In recent years, CRC incidence in China has persistently
increased. Total flavonoids (TFA) from Abelmoschus manihot, a natural compound, are recognized for
their anti-inflammatory, analgesic, and antioxidant properties. However, despite extensive research into the
therapeutic potential of TFA, coverage of its role in cancer treatment is notably lacking. To address this research
void, our study aims to unveil the role and potential mechanisms of TFA in treating CRC.

Methods:
We conducted a series of experiments to assess the impact of TFA on CRC cells. Two specific CRC
cell lines, DLD-1 and HCT116, were employed in cell proliferation, colony formation, flow cytometry, and
cell migration assays. Additionally, to test the in vivo effects of TFA, we developed a nude mouse xenograft tumor
model to assess TFA's impact on tumor growth and liver metastasis. Furthermore, we meticulously analyzed
the gene expression differences between CRC cells pretreated with TGF-β and those treated with TFA
using RNA-seq technology. We also examined the molecular mechanisms of TFA and assessed the expression
of proteins related to the STAT3/EMT signaling pathway through Western blotting and siRNA technology.

Results:
Our research findings reveal for the first time the effect of TFA on CRC cells. Result shows that TFA
could suppress cell proliferation, migration, and induce apoptosis. In vivo results showed that TFA inhibited tumor
growth and liver metastasis. Molecular mechanism studies have shown that TFA exerts these effects by
upregulating the expression of non-coding RNA AL137782, inhibiting the EMT/STAT3 signaling pathway.
These results suggest that TFA is a potential candidate for mitigating CRC metastasis.

Conclusion:
However, further research is needed to comprehensively evaluate the efficacy and safety of TFA
in animal models and clinical settings. These findings bring great hope for the development of innovative
CRC treatment methods.
The Impact of Beta-Blocker Maintenance on Decompensated Heart Failure: A Systematic Review and Meta-Analysis
Authors: da Silva Neto Luiz Fernando Leite , de Almeida Adriano Leitao , Macedo Leticia Fonseca , do Espírito Santo Caua Leal , Brito Caio Vinicius Botelho , Borges Renato Garcia Lisboa 
Published: September 2024

Background:
Acute Heart Failure (HF) is related to a significant hospital mortality rate
and functional impairment in many patients. However, there is still a lack of studies that support the
use of Beta-blockers (BB) in the management of decompensated HF. Objective: This study aimed
to evaluate the impact on mortality of maintaining BB in patients with decompensated HF.

Methods:
A systematic review and meta-analysis was performed, using the databases PubMed,
Cochrane Library, SCIELO and BVS, selecting only cohort studies and Randomized Clinical Trials
(RCTs) from the last 10 years, which have been selected based on inclusion and exclusion criteria.

Results:
An 86% reduction in the risk of in-hospital death was found (RR=0.14, 95% CI: 0.10-
0.18) in patients with HF who maintained the use of BB during hospitalization. A second analysis
found a 44% (RR=0.56, 95% CI: 0.47-0.66) lower chance of in-hospital death in the group
that previously used BB. Regarding the analysis of mortality after hospital discharge, only studies
that have evaluated the use of BB in HF with reduced ejection fraction pointed to a reduction
in mortality. Furthermore, some articles have found a relationship between the reduction in readmissions
and the use of post-discharge BB.

Conclusion:
There is still no consensus regarding the use of BB in patients hospitalized with decompensated
HF. In view of the limitations of the data found in the present study, the need for
more RCTs that address this topic is emphasized in order to resolve this uncertainty in the management
of cardiovascular patients.
Incidence of Infective Endocarditis Post-TPVR with MELODY Valve in Pediatric Patients: A Systematic Review and Meta-Analysis
Authors: Veldurthy Sruthi , Shrivastava Deepali , Majeed Farhat , Ayaz Tooba , Munir Aqssa , Haider Ali , Mylavarapu Maneeth 
Published: September 2024

Introduction:
Infective Endocarditis (IE) has emerged to be one of the most impactful
adverse complications post-transcatheter procedures, especially Transcatheter Pulmonary Valve
Replacement (TPVR). We conducted a systematic review and meta-analysis with the aim of
identifying the incidence of IE post-TPVR with the MELODY valve in the pediatric population.

Methods:
A comprehensive literature search was performed across several prominent databases,
including PubMed/MEDLINE, SCOPUS, and Science Direct. Studies compared the clinical outcomes
of pediatric patients who received TPVR using the MELODY valve. Data extraction was
done for variables like the total pediatric patient population that underwent TPVR with MELODY
valve, mean age, the sex of the patients, the incidence rate of IE following the procedure,
and the duration between the procedure and the occurrence of IE. Inverse Variance was used to
estimate the incidence of IE in patients who underwent TPVR with respective 95% confidence
interval (CI).

Results:
In total, 4 studies with 414 pediatric patients who underwent TPVR using the MELODY
valve were included in the study. The mean age of the study population was 12.7 ± 3.11
years. The pooled incidence of IE following TPVR with MELODY valve in the pediatric population
was 17.70% (95% Cl 3.84-31.55; p< 0.00001). Additionally, the mean length of duration
to develop IE following TPVR with MELODY valve in the pediatric population was 2.18 years
(95% Cl 0.35-4.01; p< 0.00001).

Conclusion:
Our meta-analysis reveals that IE post-TPVR with MELODY valve in pediatric patients
is a significant complication, clinically and statistically. Further research needs to be done
to understand the risk factors and develop better management strategies.
Optimizing Dermal Delivery of Linezolid for Treating Skin and Soft Tissue Infections: NLC-based Gel Formulation using Taguchi Design
Authors: Chauhan Iti , Singh Lubhan 
Published: September 2024

Background:
Uncomplicated skin and soft tissue infections account for approximately 200 million visits to ambulatory care settings annually. Linezolid (LNZ) is an oxazolidinone that has proven its effectiveness in combating skin and soft tissue infections caused by gram-positive pathogens. LNZ is administered via oral suspension, tablets, or an intravenous route in most in-stances. However, its extended therapy leads to undesirable side effects like diarrhoea, thrombo-cytopenia, myelosuppression, lactic acidosis, etc. and even life-threatening complications. The dermal administration of LNZ offers an alternative route, ensuring localized and sustained release at the site of infection. This approach may reduce systemic exposure and allow for lower doses compared to oral ingestion, which can decrease the risk of adverse effects.

Objective:
This research aimed to develop a nanostructured lipid carrier (NLC)-based gel for de-livering LNZ via the dermal route to treat uncomplicated skin and soft tissue infections.

Methods:
NLC were developed by high-shear homogenisation and sonication method using glyceryl trimyristate as a solid lipid and neem oil as a liquid lipid. The Taguchi design was employed to optimize NLCs using surfactant concentration (mg), drug-to-lipid ratio, and sonication time (sec) as independent variables. Their effect on particle size, zeta potential, and entrapment efficiency was studied. The optimized nanocarriers were developed into a gel product and evaluated for drug release, permeation, and antibacterial activity.

Results:
The optimised process parameters to attain outcomes were 2% surfactant, 1:1 drug-to-lipid ratio and 300 seconds of sonication. The resulting NLC had an average size of 191.2 ± 2.76 nm, a zeta potential of -30.7 ± 4.50 mV, and 84.89 ± 2.76% drug entrapment. NLC-based gel displayed anomalous transport with a 90.16 % drug release. The gel showed a strong antibacterial effect against Staphylococcus aureus with a 7.57 ± 0.12 cm mean zone of inhibition. Ex-vivo skin permeation studies revealed 24.19 ± 0.19 % drug permeation and 64.46 ± 0.58% cutaneous deposition. NLC-based gel demonstrated a significant decrease in colony-forming units in infected animal models.

Conclusion:
The ex-vivo investigations demonstrated the presence of LNZ at the infection site, enhancing therapeutic effectiveness. In vitro and in-vivo findings illustrated the substantial anti-bacterial efficacy of LNZ NLC-based gel. The adoption of NLC-based gel exhibits promising potential as a carrier for dermal delivery of LNZ.
Transcriptome Mining, Identification and In silico Characterization of Thaumatin-Like Protein Sequences from Mentha Longifolia
Authors: Chouhan Rekha , Sharma Nancy , Jamwal Vijay L. , Sharma Sahaurti , Gandhi Sumit G. 
Published: September 2024

Background:
Thaumatin-like proteins (TLPs) constitute the PR-5 family of plant pathogenesis-
related (PR) proteins and are responsible for host defense and various growth and development-
related processes. Mints (Mentha sp.) are essential oil-bearing plants, mainly affected by water
availability and fungal pathogens.

Objective:
Identification of candidate TLPs in Mentha longifolia that may help to counter pathogen
infection.

Methods:
Several bioinformatics procedures were used to identify TLP gene sequences from M.
longifolia and to characterize them for nucleotide length and composition, their translated proteins,
subcellular location, signal peptides, post translational modifications, allergenicity potential,
evolutionary relatedness, and miRNA targeting.

Result:
19 TLP candidates were identified in M. longifolia (Mlo_TLP001 - Mlo_TLP0019) annotating
the available transcriptome data. The molecular mass of Mlo_TLPs ranged between 35.43
kDa - 12.79 kDa. Expression analysis of the Mlo_TLPs revealed that Mlo_TLP003, 006, 008,
010, 012, 013, 014, and 018 were upregulated in M. longifolia stem as compared to the root under
control conditions. Further, the analysis of control and V. dahliae infected M. longifolia plants has
shown Mlo_TLP006 to be upregulated in both the infected stem and root tissues as compared to
the control.

Conclusion:
Mlo_TLP006 is a probable candidate that imparts resistance to fungal pathogens in
Mentha longifolia.
The Effects of Audit Partner Industry Experience on Lowballing, Subsequent Audit Fees, and Audit Quality
Authors: Desai Naman , Mishra Birendra , Mock Theodore J. , Purohit Siddharth 
Published: September 2024

SUMMARY
Audit fee lowballing is defined as charging relatively lower audit fees at the start of an audit engagement and increasing fees subsequently to recover the initial lowballing cost. This practice, employed to attract new clients, concerns regulators because of its potential consequences for audit quality. We examine the relation between audit partner industry experience and lowballing, and its implications for subsequent audit fees and audit quality. Our results indicate that higher audit partner industry experience is associated with discounted fees but superior audit quality in the first year of the engagement, suggesting that more-experienced auditors pass on cost savings from process efficiencies to their clients. We also find that for audit partners with higher (lower) industry experience, subsequent fee increases are relatively low (high). This implies that auditors with lower industry experience lowball in the initial year of the engagement and subsequently hike fees to recover the initial-year lowballing costs.
Data Availability: Data used in this study are available from public sources identified in the text.
JEL Classifications: M42.
In Search of Informed Discretion (Revisited): Are Managers Concerned about Appearing Selfish?
Authors: Dierynck Bart , van der Geest Jesse , van Pelt Victor 
Published: September 2024

ABSTRACT
Managers can undertake a costly search to gather additional information about employee performance. Previous management accounting research attributed these actions to inherent social preferences, such as fairness and reciprocity. To further refine this explanation, we conducted a replication and extension of prior experimental work. Our findings suggest that managers’ willingness to gather additional information at their own expense also depends on situational factors, particularly situational factors altering managers’ concerns of being perceived as selfish if they do not gather additional information. These findings align with insights from behavioral economics and social psychology, indicating that situational factors may induce self-interested individuals to exhibit prosocial behavior. The implication of our result is that creating working conditions that increase managers’ concerns about appearing selfish may encourage them to make more informed performance evaluation and compensation decisions.
Data Availability: Experimental instrument and software are publicly available on the Open Science Framework platform. Data are available on request.
JEL Classifications: C92; D91; M40; M41.
Strategic Alignment, Performance, and the Moderating Effect of Regulatory Fit
Authors: Gunnell Hayden T. , Smith Steven D. , Steadman Travis W. 
Published: September 2024

ABSTRACT
We examine how the alignment of performance measurement and strategy affects performance on a multidimensional task. Our experiment varies both the strategy (speed versus accuracy) of the hypothetical firm for which participants work and the individual performance measure that is reported to them, creating two conditions of clear alignment and two of clear misalignment. We find that although workers are responsive to the performance measure regardless of its alignment, they are also sensitive to the strategy such that costly alignment effects are observed. We also predict and find that workers respond asymmetrically to misalignment in accuracy performance but not in speed performance, demonstrating that the effects of misaligned performance measurement depend on the fit between firm strategy and the nature of the task being performed.
Data Availability: Data are available from the authors upon request.
JEL Classifications: M40; M41; M50.
ESTÁGIO SUPERVISIONADO NA FORMAÇÃO INICIAL EM PEDAGOGIA NO CONTEXTO DA PANDEMIA DO NOVO CORONAVÍRUS
Authors: Araújo Rosalia de Aguiar , Carvalho Sandra Pereira de , Moraes Saulo Augusto de , Trugillo Edneuza Alves , Neves Oseias Carmo 
Published: September 2024

O Estágio Curricular Supervisionado é um dos componentes curriculares que compõem o Projeto Pedagógico do curso de Pedagogia da Universidade do Estado de Mato Grosso - UNEMAT - campus de Juara/MT, os quais devem acontecer no decorrer do curso, garantindo aos graduandos a atuação pedagógica em contextos escolares e não escolares. A suspensão das aulas presenciais em todos os níveis e modalidades pelas autoridades sanitárias e educacionais devido à pandemia do novo coronavírus em todo o país, foi seguida posteriormente pela determinação de substituir as aulas presenciais por virtuais com a utilização de meios digitais, o que fez com que as instituições de ensino superior migrassem para o ensino remoto emergencial. Este artigo tem como objetivo analisar se o Estágio Curricular Supervisionado ofertado pelo curso de Pedagogia da UNEMAT de Juara, por meio do ensino remoto, conseguiu desenvolver a ementa, as pretensões e orientações previstas no seu Projeto Pedagógico. Por meio de análise dos relatório de estágio e entrevistas remotas, as narrativas dos estagiários e das estagiárias teceram os desafios, inquietudes e aprendizagens que foram potencializados pelo ensino remoto. Concluiu-se que, apesar de dar condições para a integralização dos componentes curriculares, o ensino remoto não se constitui como ferramenta apropriada para abranger a complexidade da práxis pedagógica, o que só é possível pelo ensino presencial.
Sociodemographic, Educational and Psychological Characteristics in First-Time Consultants of Psychological Care Service
Authors: Sierra Miguel Ángel Tuz , Rodríguez Vida Esther Navarrete-Machain , Reyes Liliana García , Uc Carlos Efren Huitz , Aranda Gabriela Isabel Pérez 
Published: September 2024

Objective: The purpose of the research was to compare the sociodemographic, educational and psychological characteristics in first-time consultants from university psychological care service after the COVID 19 pandemic. Theoretical Framework: Research has identified the need to characterize the population that receives psychological care as a priority. Method: It was a quantitative study with a cross-sectional, descriptive-correlational design. The sample consisted of 119 people (76.5% women and 23.5% men), who requested the service between the months of February and July 2023. The Anxiety Scale (BAI), the Beck Depression Scale (BDI) were used., in addition to a sociodemographic questionnaire. Results and Discussion: It was found that the population that requested the service was made up mostly of women (76.5%, n=91) of 11-21 years. “Emotional instability” (27.73%) was found as the main reason for consultation, followed by “anxiety symptoms” (17.64%) and “depressive symptoms” (9.24%). Regarding the levels of depression, it was found that 41.2% of the sample is at a moderate level, followed by a severe level in 26.9%. Regarding the levels of anxiety, it was found as mild as moderate degree in 36.1% while 21% of the consultants were at a severe level. According to the Chi Square test, it is concluded that neither depression nor anxiety depend on sex. Research Implications: The data obtained makes it possible to demonstrate the impact on mental health that the pandemic has had on university populations. Originality/Value: The results favor the possibility of developing effective care strategies according to the characterizations found.
Staying with the Climate Trouble
Authors: Zimmerman Lee 
Published: September 2024

In teaching about climate, when it comes to the troubling question of “what can we do?” I’ve argued that we try to help students stay with, rather than prematurely and inadequately, resolve that trouble and that we do this by inviting them into our own state of not knowing. How to stay with the pedagogical trouble of doing that, including the trouble of trying to contain the despair that an honest account of the climate crisis may provoke? This essay suggests that one approach to that question in the literature classroom is to teach texts in which characters themselves grapple with the question of “what can we do?” Ultimately, the pedagogical challenge is to help shape these textual encounters into an awareness that, especially as it is shared, despair might be something other than a terminal condition—indeed, might be a necessary passage through to whatever comes next.
ГОНЧАРНОЕ КЛЕЙМО СО ЗНАКОМ РЮРИКОВИЧЕЙ ИЗ СТАРОЙ РЯЗАНИ
Authors: Стрикалов И.Ю. , Чернецов А.В. 
Published: September 2024

Статья посвящена публикации фрагмента керамического сосуда из раскопок в Старой Рязани с гончарным клеймом на днище, на котором изображен лично-родовой юридический знак (знак Рюриковичей). Принадлежность знака к княжеским представляется неоспоримой. Типологически он тяготеет к ранним знакам (рубежа X–XI вв.), однако датируется не ранее XII в. Использование подобных знаков в качестве гончарных клейм свидетельствует о том, что последние, несомненно, находятся в близкой связи с владельческими юридическими знаками.
The paper publishes a fragment of a clay pot from the excavations in Staraya Ryazan with a pottery mark on the bottom featuring a personal legal family crest (the symbol of the Rurikids). The attribution of the sign to a princely family is not disputable. Typologically it is closer to the earlier signs (dated to the turn of the 11th century), though it dates not earlier than the 12th century. The use of such signs as pottery marks means that they are closely connected to personal symbols used to denote legal property rights over various items.
Лестничная башня в Боголюбове (по материалам раскопок 2015 года)
Authors: Седов Вл.В. 
Published: September 2024

Статья посвящена новым данным, полученным в результате раскопок комплекса в Боголюбове близ Владимира в 2015 г. Помимо новых сведений об архитектуре церкви, построенной при князе Андрее Боголюбском, эти раскопки позволили впервые внимательно изучить основание угловой колонки лестничной башни и установить уровень первоначальной дневной поверхности. Эти данные дают основания для сравнения профилей в различных частях комплекса в Боголюбове, а также для сопоставления этих профилей с различными романскими профилями, в том числе итальянскими. Кроме того, появляется возможность частично реконструировать первоначальный вид башни и всего комплекса. Композиция башни находит себе аналогию не только в Италии романской поры, но и, например, в церкви аббатства Сан-Реми в Реймсе, где фланкирующие западный фасад башни имеют примерно такой же размер и иконографию фасадов.
The paper introduces new data obtained from the excavations of the ensemble in Bogolyubovo near Vladimir in 2015. Besides the new data on the architecture of the church built under Prince Andrei Bogolyubsky, these excavations provided a possibility to study the base of the corner pillar of the stair tower for the first time and identify the level of the original soil surface. These data provide grounds for comparing profiles in different parts of the Bogolyubovo ensemble as well as comparing these profiles with various Romanesque profiles, including Italian profiles. In addition to that, it is now possible to partially reconstruct the original appearance of the tower and the entire ensemble. The design of the tower finds parallels not only in Italy of the Romanesque period but also in the Abbey of Saint-Remi in Reims where the towers flanking the western façade have roughly the same size and the iconography of the facades.