bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lip b 1 is a novel allergenic protein isolated from the booklouse, Liposcelis bostrychophila
Authors: Ishibashi O. , Sakuragi K. , Fukutomi Y. , Kawakami Y. , Kamata Y. , Sakurai M. , Nakayama S. , Uchiyama H. , Kobayashi H. , Kojima H. , Inui T. 
Published: November 2016

AbstractBackgroundBooklice, belonging to the order Psocoptera, are small household insect pests that are distributed worldwide. Liposcelis bostrychophila, a common home‐inhabiting species of booklouse, infests old books, sheets of paper, and stored food. Recent entomological and serological studies demonstrated that L. bostrychophila accounted for the majority of detectable insects in house dust and could be a potent inducer of respiratory allergy. Our recent proteomic analysis identified a potent allergenic protein from L. bostrychophila, designated Lip b 1, and determined its partial amino acid sequences.MethodsCloning of cDNAs for Lip b 1 was performed by large‐scale transcriptome analysis (RNA‐seq) and subsequent reverse transcription polymerase chain reaction. The full‐length amino acid sequences deduced from Lip b 1 cDNAs were bioinformatically analyzed. The recombinant proteins of glutathione S‐transferase (GST)‐fused Lip b 1 were analyzed by Western blot and enzyme‐linked immunosorbent assay.ResultsLip b 1 cDNAs encoding two types of 254‐amino acid proteins were cloned. The clones shared 87% identity, and the deduced molecular weights and isoelectric points were consistent with those determined in our previous study. The two types of Lip b 1 proteins in the GST‐fused form were similarly reactive with sera from allergic patients sensitized with L. bostrychophila.ConclusionsLip b 1 is a novel protein possibly causing booklouse allergy.
Defining pollen exposure times for clinical trials of allergen immunotherapy for pollen‐induced rhinoconjunctivitis – an EAACI position paper
Authors: Pfaar O. , Bastl K. , Berger U. , Buters J. , Calderon M. A. , Clot B. , Darsow U. , Demoly P. , Durham S. R. , Galán C. , Gehrig R. , Gerth van Wijk R. , Jacobsen L. , Klimek L. , Sofiev M. , Thibaudon M. , Bergmann K. C. 
Published: November 2016

AbstractBackgroundClinical efficacy of pollen allergen immunotherapy (AIT) has been broadly documented in randomized controlled trials. The underlying clinical endpoints are analysed in seasonal time periods predefined based on the background pollen concentration. However, any validated or generally accepted definition from academia or regulatory authorities for this relevant pollen exposure intensity or period of time (season) is currently not available. Therefore, this Task Force initiative of the European Academy of Allergy and Clinical Immunology (EAACI) aimed to propose definitions based on expert consensus.MethodsA Task Force of the Immunotherapy and Aerobiology and Pollution Interest Groups of the EAACI reviewed the literature on pollen exposure in the context of defining relevant time intervals for evaluation of efficacy in AIT trials. Underlying principles in measuring pollen exposure and associated methodological problems and limitations were considered to achieve a consensus.ResultsThe Task Force achieved a comprehensive position in defining pollen exposure times for different pollen types. Definitions are presented for ‘pollen season’, ‘high pollen season’ (or ‘peak pollen period’) and ‘high pollen days’.ConclusionThis EAACI position paper provides definitions of pollen exposures for different pollen types for use in AIT trials. Their validity as standards remains to be tested in future studies.
Airway eosinophil migration into lymph nodes in mice depends on leukotriene C4
Authors: Wang H.‐B. , Akuthota P. , Kanaoka Y. , Weller P. F. 
Published: November 2016

AbstractBackgroundWe previously demonstrated in mice that airway eosinophils traffic from the airway lumen into lung‐draining paratracheal lymph nodes. However, mechanisms whereby eosinophils traverse from the lungs and home to paratracheal lymph nodes remain unclear. We investigated roles of cysteinyl leukotrienes in mediating eosinophil trafficking from lungs to paratracheal lymph nodes.MethodsThe expression of CCR7 was determined by flow cytometry. Transwell assays were used to test chemotactic responses of leukotriene C4 synthase‐deficient and control airway eosinophils to the chemokine CCL19 ex vivo. Eosinophils from the spleens of IL‐5 transgenic mice, fluorescently labeled ex vivo, were intratracheally injected into ovalbumin‐sensitized and ovalbumin aerosol‐challenged leukotriene C4 synthase‐deficient and control mice. Eosinophils were identified by microscopy and flow cytometry in the lungs and paratracheal lymph nodes.ResultsMouse eosinophils expressed CCR7, the receptor for CCL19, and responded chemotactically to CCL19. Leukotriene C4 synthase‐deficient eosinophils exhibited impaired chemotaxis to CCL19 that was restored by exogenous leukotriene C4. The migration of intratracheally injected eosinophils into paratracheal lymph nodes from distal alveolar lung was diminished in leukotriene C4 synthase‐deficient mice compared with wild‐type mice, with increased retention of eosinophils in the lungs of leukotriene C4 synthase‐deficient mice. Exogenous administration of leukotriene C4 restored trafficking of eosinophils to paratracheal lymph nodes in leukotriene C4 synthase‐deficient mice.ConclusionsOur findings that cysteinyl leukotrienes are involved in regulating airway and lung eosinophil migration into paratracheal lymph nodes identify previously unrecognized roles for the cysteinyl leukotrienes in regulating the pulmonary trafficking of eosinophils in experimental allergic asthma.
The cross‐publics of ethnography: The case of “the Muslimwoman”
Authors: ABU‐LUGHOD LILA 
Published: November 2016

ABSTRACTEngaged anthropology, public anthropology, and public ethnography are names for a long tradition of trying to make a difference beyond the academy. The passionate and polarized responses of both nonacademic publics and engaged scholars in adjacent fields to my attempt to intervene in public debates about Muslim women's rights raise questions about the ethics, politics, and potentials of ethnography's travels across fractured global publics. They illuminate the geopolitical terrain of current debates about feminism and Islamophobia and reveal that ethnography may be most effective in interrupting or unsettling hegemonic representations and political formations when it makes available alternative accounts of lives and communities that can then authorize and give substance to critics’ arguments. Does this instrumentalization of ethnography benefit those whose lives anthropologists share through fieldwork? [engaged anthropology, public ethnography, rights, ethics, feminism, Islamophobia, Muslim women]
A civilized revolution: Aesthetics and political action in Egypt
Authors: WINEGAR JESSICA 
Published: November 2016

ABSTRACTActs of aesthetic ordering dominated Egyptian protest and civic activity in 2011, around the time of former president Hosni Mubarak's downfall. They played a central role in motivating collective political action, giving form to a nationalist utopian vision and legitimizing ordinary Egyptians as active agents and upright citizens. Yet they also reproduced exclusionary middle‐class aspirations tied up with state projects and related forms of citizenship that center on surveillance, individualism, and consumption. Examining such acts of aesthetic ordering reveals the tensions at the heart of many political movements, especially as people attempt to enact their utopian visions in public space. The precarity of both middle classness and utopian schemes of revolution render aesthetics a key battleground of political action. [activism,social movements,aesthetics,space,middle class,waste,Egypt]
The ends of cutting in Ghana: Blood loss, scarcity, and slow harm after NGOs
Authors: HODŽIĆ SAIDA 
Published: November 2016

ABSTRACTFemale genital cutting is waning in northeastern Ghana, even though NGO and state discourses suggest otherwise. Women who no longer perform the practice do not, as anthropologists often posit, resist anticutting advocacy. Rather, they critique what NGO and state interventions leave unaddressed. These women understand the ending of cutting as an index of food scarcity and governance that saps their blood and vitality. Cutting had to stop, they say, because they could no longer afford to lose more blood. Drawing on indigenous and biomedical understandings of health and popular notions of occult economies, they critique the contemporary governance that simultaneously invests in their lives and causes bodily attrition. “Slow harm” reveals how the invisible violence of neoliberal democracy produces ordinary crises and makes bodies vulnerable.
Producing iyashi: Healing and labor in Tokyo's sex industry
Authors: KOCH GABRIELE 
Published: November 2016

ABSTRACTWomen working in the Japanese sex industry provide deeply gendered affective labor to male white‐collar workers. Their services center on iyashi (healing), a carefully constructed performance of intimacy that commingles maternal care with sexual gratification. Sex workers value this labor as providing socially necessary care to men who work in valorized sectors of the Japanese economy. Yet their own labor is produced within conditions of economic precarity. Moreover, intimate encounters in the sex industry are never divorced from the terms of a gendered economy. Sex workers use gendered discourses of productivity that reflect hierarchies of the value of labor to shape their performances of intimate care. These discourses demonstrate the centrality of gendered assumptions to conceptions of production and the economy. [affective labor, gender, sex work, productivity, care, precarity, Japan]現代の日本性風俗業界で働いている女性は、 ジェンダー化された感情労働を、とりわけホワイトカラー層の男性客に提供している。セックスワーカーのサービスは「癒し: healing」を中心として成り立っている。ここで議論される 「癒し」とは、母性的なケアと性欲処理を混合させる事によって親密さを入念に演出する、構成されたパフォーマンスである。セックスワーカー達は、自身の労働が日本経済において重要な地位を占める男性から必要とされているのだから価値があると思っているが、性風俗の仕事は経済的に不安定な条件の中で営まれている。それに加え性風俗業界内での親密な出会いは、ジェンダー化された経済の条件から切り離す事はできない。セックスワーカーは生産性に関するジェンダー化した言説を用いるが、それは彼女らの親密なケアを形成する労働の価値の階層を映し出している。これらの言説は、「生産」や「経済」の概念形成の中心に、ジェンダー的前提が存在していることを明証している。「感情労働、ジェンダー、セックスワーク、生産性、ケア、不安定さ、日本」
Impact of Residual Mitral Regurgitation on Right Ventricular Systolic Function After Left Ventricular Assist Device Implantation
Authors: Ertugay Serkan , Kemal Hatice S. , Kahraman Umit , Engin Catagay , Nalbantgil Sanem , Yagdi Tahir , Ozbaran Mustafa 
Published: November 2016

AbstractSignificant mitral regurgitation (MR) is thought to decrease after left ventricular assist device (LVAD) implantation, and therefore repair of mitral valve is not indicated in current practice. However, residual moderate and severe MR leads to pulmonary artery pressure increase, thereby resulting in right ventricular (RV) dysfunction during follow‐up. We examined the impact of residual MR on systolic function of the right ventricle by echocardiography after LVAD implantation. This study included 90 patients (mean age: 51.7 ± 10.9 years, 14.4% female) who underwent LVAD implantation (HeartMate II = 21, HeartWare = 69) in a single center between December 2010 and June 2014. Echocardiograms obtained at 3–6 months and over after implantation were analyzed retrospectively. RV systolic function was graded as normal, mild, moderate, and severely depressed. MR (≥moderate) was observed in 43 and 44% of patients at early and late period, respectively. Systolic function of the RV was severely depressed in 16 and 9% of all patients. Initial analysis (mean duration of support 174.3 ± 42.5 days) showed a statistically significant correlation between less MR and improved systolic function of RV (P = 0.01). Secondary echocardiographic analysis (following a mean duration of support of 435.1 ± 203 days) was also statistically significant for MR degree and RV systolic dysfunction (P = 0.008). Residual MR after LVAD implantation may cause deterioration of RV systolic function and cause right‐sided heart failure symptoms. Repair of severe MR, in selected patients such as those with severe pulmonary hypertension and depressed RV, may be considered to improve the patient's clinical course during pump support.
Correlation of vitamin D levels with tear film stability and secretion in patients with dry eye syndrome
Authors: Jin Ki Won , Ro Jin Woo , Shin Young Joo , Hyon Joon Young , Wee Won Ryang , Park Shin Goo 
Published: November 2016

AbstractPurposeTo investigate tear film stability and secretion according to serum 25‐hydroxyvitamin D3 [25(OH)D] levels in dry eye patients.MethodsIn this retrospective observational study, the medical charts of 92 patients who visited the Department of Ophthalmology at Hallym University Kangnam Sacred Heart Hospital from April to August 2015 were reviewed. Serum 25(OH)D levels were measured. Subjects were divided into three groups according to serum 25(OH)D levels: sufficient, inadequate or deficient group. Eye discomfort was measured by ocular surface disease index (OSDI). Tear break‐up time (TBUT), fluorescein staining score and Schirmer's tear secretion test were measured.ResultsThe mean age was 53.38 ± 13.69 years. Mean serum 25(OH)D level was 14.41 ± 5.98 ng/ml. Tear break‐up time (TBUT) and tear secretion were positively correlated with serum 25(OH)D levels (r = 0.389, p = 0.001; and r = 0.428, p < 0.001, Pearson correlation test). Tear break‐up time (TBUT) and tear secretion were shorter in the vitamin D‐deficient group compared to the sufficient group (p = 0.022 and p = 0.004). Fluorescein staining scores and OSDI scores were not different between the three groups.ConclusionTear break‐up time (TBUT) and secretion were correlated with serum vitamin D levels. Vitamin D status may be an important factor for dry eye syndrome.
Predicting the intereye asymmetry in functional and structural damage in glaucoma using automated pupillography
Authors: Rao Harsha L. , Kadambi Sujatha V. , Dasari Srilakshmi , Reddy Hemanth B. , Palakurthy Meena , Riyazuddin Mohammed , Puttaiah Narendra K. , Pradhan Zia S. , Rao Dhanaraj A. S. , Shetty Rohit 
Published: November 2016

AbstractPurposeTo predict the intereye asymmetry in functional (mean deviation, MD on visual field, VF) and structural (retinal nerve fibre layer, RNFL and ganglion cell complex, GCC thickness on spectral domain optical coherence tomography, SDOCT) measurements in glaucoma using the automated pupillography parameters.MethodsFifty‐nine subjects with a diagnosis of either glaucoma or glaucoma suspect underwent automated pupillography along with VF and SDOCT examinations. Association between pupillography and the absolute intereye difference in MD, RNFL and GCC measurements was evaluated using regression analysis after accounting for the multicollinearity.ResultsUnivariate regression analysis showed statistically significant associations (p < 0.05) between multiple pupillography parameters and the intereye difference in MD, RNFL and GCC thickness measurements. Multivariate regression with less strongly correlated parameters identified intereye difference in amplitude change (Ac) per cent to be the parameter that best predicted the intereye asymmetry in MD (Intereye asymmetry in MD = 2.20 + 1.33*intereye difference in Ac per cent, R2 = 0.36), RNFL thickness (3.38 + 3.55*intereye difference in Ac per cent, R2 = 0.49) and GCC thickness (4.49 + 2.06* intereye difference in Ac per cent, R2 = 0.41). Ability of intereye Ac per cent difference to predict intereye asymmetry in MD, RNFL and GCC thickness was better in patients with angle closure disease (R2 = 0.38, 0.79, 0.66, respectively) compared to those with open angles (R2 = 0.25, 0.15, 0.16, respectively).ConclusionsIntereye asymmetry in MD, RNFL and GCC thickness measurements was best predicted by the intereye difference in Ac per cent on automated pupillography. The predicting ability was better in patients with angle closure compared to those with open angles.
Outcome of intra‐arterial chemotherapy for retinoblastoma and its influencing factors: a retrospective study
Authors: Chen Miaojuan , Jiang Hua , Zhang Jing , Shen Gang , Jiang Yizhou , Li Haibo , Liu Zhenyin 
Published: November 2016

AbstractPurposeIntra‐arterial chemotherapy (IAC) has become an essential technique for the treatment of advanced and relapsed intra‐ocular retinoblastoma. The outcome of IAC for retinoblastoma is influenced by a variety of medical and non‐medical factors. In this study, we aimed to examine the outcome of IAC and determine the factors influencing clinical outcome.MethodsA total of 107 eyes of 73 patients with retinoblastoma undergoing IAC between January 2011 and April 2013 were retrospectively reviewed for clinical outcomes. The factors influencing clinical outcomes were determined using univariate and multivariate analyses.ResultsAfter IAC, an overall globe salvage rate of 78.5% was observed during follow‐up periods. Specifically, globe salvage was achieved in Group B (100%), Group C (100%), Group D (78.6%), and Group E (62%). Short‐term ocular adverse events included eyelid oedema (14%), bulbar conjunctiva congestion (29.9%) and excessive tearing (9.3%). Long‐term complications included vitreous haemorrhage (8.4%), subretinal haemorrhage (9.3%), retinal vasculopathy (7.5%) and ophthalmic artery spasm with reperfusion (4.7%). Univariate and multivariate analyses showed that the globe salvage of IAC was significantly associated with tumour staging and previous treatment (p < 0.05, respectively).ConclusionIntra‐arterial chemotherapy (IAC) is safe and effective for the management of retinoblastoma. Patients with advanced retinoblastoma and previous failed treatment may have a poor outcome after IAC.
A comparison of left and right atrial fibroblasts reveals different collagen production activity and stress‐induced mitogen‐activated protein kinase signalling in rats
Authors: Chung C.‐C. , Kao Y.‐H. , Yao C.‐J. , Lin Y.‐K. , Chen Y.‐J. 
Published: November 2016

AbstractAimAtrial fibrosis plays a pivotal role in the pathophysiology of heart failure (HF). The left atrium (LA) experiences greater fibrosis than the right atrium (RA) during HF. It is not clear whether LA cardiac fibroblasts contain distinctive activities that predispose LA to fibrosis.MethodsLA and RA fibrosis were evaluated in healthy and isoproterenol‐induced HF Sprague Dawley rats. Rat LA and RA primary isolated fibroblasts were subjected to proliferation assay, oxidative stress assay, cell migration analysis, collagen measurement, cytokine array and Western blot.ResultsHealthy rat LA and RA had a similar extent of collagen deposition. HF significantly increased fibrosis to a greater severity in LA than in RA. Compared to isolated RA fibroblasts, the in vitro experiments showed that isolated LA fibroblasts had higher oxidative stress and exhibited higher collagen, transforming growth factor‐β1, connective tissue growth factor production and less vascular endothelial growth factor (VEGF) production, but had similar migration, myofibroblast differentiation and proliferation activities. VEGF significantly increased the collagen production ability of LA fibroblasts, but not RA fibroblasts. LA fibroblasts had more phosphorylated ERK1/2 and P38 expression. ERK inhibitor (PD98059, 50 μmol L−1) significantly attenuated collagen production and increased VEGF production in RA fibroblasts but not in LA fibroblasts. P38 inhibitor (SB203580, 30 μmol L−1) significantly attenuated collagen production in LA fibroblasts but not in RA fibroblasts. P38 inhibitor also significantly increased VEGF production in RA and LA fibroblasts.ConclusionsDifferences in profibrotic activity between LA and RA fibroblasts may be caused by different responses to mitogen‐activated protein kinase signalling.
SSRI and SNRI use during pregnancy and the risk of persistent pulmonary hypertension of the newborn
Authors: Bérard Anick , Sheehy Odile , Zhao Jin‐Ping , Vinet Évelyne , Bernatsky Sasha , Abrahamowicz Michal 
Published: November 2016

AimThe use of selective serotonin reuptake inhibitors (SSRIs) in late pregnancy may be associated with an increased risk of persistent pulmonary hypertension of the newborn (PPHN). Limited data are available on the risk of PPHN associated with serotonin norepinephrine reuptake inhibitors (SNRIs). We aimed to quantify both associations.MethodsUsing data from the Quebec Pregnancy Cohort between 1998 and 2009, we included women covered by the provincial drug plan who had a singleton live birth. Exposure categories were SSRI, SNRI and other antidepressant use; non‐users were considered as the reference category. Generalized estimating equation models were used to obtain risk estimates and 95% confidence intervals (CIs). Confounding by indication was minimized by adjusting for history of maternal depression/anxiety before pregnancy.ResultsOverall, 143 281 pregnancies were included; PPHN was identified in 0.2% of newborns. Adjusting for maternal depression, and other potential confounders, SSRI use during the second half of pregnancy was associated with an increased risk of PPHN [adjusted odds ratio (aOR) 4.29, 95% CI 1.34, 13.77] compared with non‐use of antidepressants; SNRI use during the same time window was not statistically associated with the risk of PPHN (aOR 0.59, 95% CI 0.06, 5.62). Use of SSRIs and SNRIs before the 20th week of gestation was not associated with the risk of PPHN.ConclusionsUse of SSRIs in the second half of pregnancy was associated with the risk of PPHN. Given our results on SNRIs and the lack of statistical power for these analyses, it is unclear whether SNRI use during pregnancy also increases the risk of PPHN.
Glucose and lipid levels with lanreotide autogel 120 mg in treatment‐naïve patients with acromegaly: data from the PRIMARYS study
Authors: Caron Philippe J. , Petersenn Stephan , Houchard Aude , Sert Caroline , Bevan John S. ,   the PRIMARYS Study Group
Published: November 2016

SummaryObjectiveImpaired glycaemic control, characteristic of acromegaly, can be exacerbated by treatment with somatostatin analogues (SSAs), particularly those with multireceptor activity. We present data from the PRIMARYS study on the impact of the SSA lanreotide, associated with tumour volume and hormonal improvements, on glucose and other metabolic parameters in acromegaly.DesignPRIMARYS was a 48‐week open‐label single‐arm phase 3b study of lanreotide autogel 120 mg/4 weeks. A priori and post hoc metabolic profile data are reported for the overall population, patients with/without diabetes and patients achieving/not achieving hormonal control.PatientsTreatment‐naïve adults with pituitary macroadenoma, mean growth hormone >1 μg/l and elevated insulin‐like growth factor‐1 levels (n = 90).MeasurementsGlycaemic parameters [glycated haemoglobin (HbA1c) and fasting plasma glucose (FPG) levels] assessed at baseline and weeks 12, 24 and 48. Lipid‐profile data (triglycerides, total cholesterol, high‐density lipoprotein cholesterol and low‐density lipoprotein cholesterol) collected at baseline and study end.ResultsIn patients with diabetes (n = 24), HbA1c showed a clinically relevant decrease during treatment [mean change from baseline to week 48, −1·44% (95% CI: −2·52, −0·36)]. In the overall population, in patients without diabetes, or in patients with/without hormonal control, HbA1c did not significantly change by week 48. Mean FPG levels showed no significant change by week 48 in all populations. Individually, increases and decreases in glycaemic parameters affected some patients in all populations. Glycaemic status as a composite measure of HbA1c and FPG (classification as normal, mild or diabetic) was stable from baseline to study end in most patients (overall, 70%; patients with diabetes, 50%; patients without diabetes, 76%), but worsened by week 48 in nine (15%) patients [seven (50%) with diabetes at baseline] and improved in nine (15%) patients (none with diabetes). Changes in lipid profiles were not considered clinically meaningful.ConclusionsGlucose and lipid levels were not detrimentally affected in most patients, while only a relatively small proportion showed deterioration in glucose control.