bluuebunny/crossref_metadata_2025_split huggingface dataset:
Problems and their solutions in accompanying therapy of oncological patients: regulatory and financial strategic approaches to solutions
Authors: Gabay P. G. 
Published: October 2024

Accompanying therapy (AT) is vital for oncological patients as it allows to alleviate complications associated with both cancer and antitumor therapy. These complications include anemia, febrile neutropenia, nausea, and chronic pain syndrome. The problem is that many patients do not receive sufficient AT because of the lack of clinical guidelines and regulations. Currently, clinical guidelines only for anemia are approved and none for the other complications. The main barriers are the absence of legislative funding of AT and impossibility to obtain medications on the outpatient basis. The system of clinical-statistical disease groups also causes difficulties with payment for medical treatment. Low cost ratios and impossibility to combine AT payment with payment for the main therapy also limit its availability.To solve these problems, separate clinical guidelines for AT should be developed, tariffs for the clinical-statistical disease groups should be revised, and coefficients of treatment complexity should be increased for wider medication coverage.
Evaluation of an Open Earthquake Early Warning System in Mexico, and Laboratory Tests of their Sensors
Authors: Kuna Vaclav , Ringler Adam T. , Melgar Diego 
Published: October 2024

Abstract
Microelectromechanical system (MEMS) accelerometers are useful for seismological and engineering applications because of their ability to record unsaturated large seismic signals. Recent advances in MEMS technologies enable the design of instruments with improved capabilities that also allow the recording of small signals. As a result, MEMS can be useful across a broad dynamic range and for both major earthquakes and smaller magnitude events. Here, we analyze the performance of a MEMS-based accelerometer with the capability of real-time data transmission. We discuss the self-noise level, dynamic range, and sensitivity, along with the timing precision and data transmission latency, and compare these parameters to other MEMS-based instruments. We also summarize observations from a regional network deployed in southern Mexico over a period of 3+ yr for the purpose of earthquake early warning. In addition to the sensor evaluation, we present a large, openly available data set of strong motion data from the Mexican network that comprises continuous ground-motion records from 24 accelerometers in the period between 2017 and 2022.
Bayesian Earthquake Forecasting Using Gaussian Process Modeling: GP-ETAS Applications
Authors: Molkenthin Christian , Zöller Gert , Hainzl Sebastian , Holschneider Matthias 
Published: October 2024

Abstract
Numerous seismicity models are known to simulate different observed characteristics of earthquake occurrence successfully. However, their ability of prospective forecasting future events is a priori not always known. The recently proposed semiparametric model, Gaussian process epidemic-type aftershock sequence (GP-ETAS) model, which combines the ETAS model with GP modeling of the background activity, has led to promising results when applied to synthetic seismicity. In this study, we focus on the ability of GP-ETAS for different forecasting experiments in two case studies: first, the Amatrice, Italy, sequence during 2016 and 2017, and second, long-term seismicity in Southern California. The results indicate that GP-ETAS performs well compared with selected benchmark models. The advantages become particularly visible in cases with sparse data, in which GP-ETAS shows in general a more robust behavior compared to other approaches.
Biomechanical Parameters of the Cornea in Patients Who are Candidates for Laser Refractive Surgery with Complex Myopic Astigmatism and Dry Eye Syndrome
Authors: Klokova О. A. , Sakhnov S. N. , Zabolotniy A. G. , Аliev M. B. , Kacharov A. I. 
Published: October 2024

Purpose. To analyze the corneal indices obtained during examination with the Corvis® ST device of myopic patients — candidates for laser refractive surgery with dry eye syndrome (DES), before and after its treatment.Patients and methods. Study group I consisted of 88 patients with mild to moderate dry eye syndrome according to the classification of the International Seminar on Dry Eye Syndrome (TFOS DEWS II Definition and Classification Report), group II — 88 patients with no signs of corneal-conjunctival xerosis with complex myopic astigmatism at the age of 18 to 45 years (29.01 ± 7.68). The study of biomechanical parameters of the patients’ cornea was carried out using Corvis® ST (Oculus, Germany).Results. During the initial examination, six out of ten biomechanical indicators (DAM, A1T, A1V, A2T, A1L, SP_A1) in patients of study group I were significantly different (p < 0.05) from the indicators of study group II, the rest (A2V, A2L, HC_time, PD) were comparable (p > 0.05). Complex indices CBI, BAD_D in patients with DES were also statistically significantly (p < 0.05) different from those of patients without signs of DES and did not change after treatment for DES (p > 0.05). During the initial examination of patients in group I, 37 patients (42 %) had TBI in the range of 0.5–0.9. Against the background of conservative treatment of dry eye syndrome, the number of such patients decreased to 20 (22 %), and with a TBI level of up to 0.3 it increased to 30 (34 %).Conclusion. The values of corneal biomechanical parameters determined during examination on Corvis® ST in patients with dry eye syndrome are different from those of patients without symptoms of corneal-conjunctival xerosis. Improving the condition of the ocular surface against the background of drug correction of dry eye syndrome and, as a result, improving the TBI index, provides a better selection of patients for laser refractive surgery and the choice of method for its implementation. The influence of asymptomatic dry eye syndrome in a significant number of patients on the value of corneal parameters studied on Corvis® ST determines the need for preventive diagnosis of dry eye disease in the general algorithm for examining all patients before refractive surgery.
Text Book of Medicinal Chemistry-I for the Students of B.Pharm 4th Semester
Authors: Kemisetti Dr. Durga Prasad 
Published: October 2024

Scope

This subject is designed to impart fundamental knowledge on the structure, chemistry and therapeutic value of drugs.
The subject emphasizes on structure activity relationships of drugs, importance of physico-chemical properties and metabolism of drugs.
The syllabus also emphasizes on chemical synthesis of important drugs under each class.

Outcomes- Upon completion of the course students shall be able:

To understand the chemistry of drugs with respect to their pharmacological activity.
To understand the drug metabolic pathways, adverse effects and therapeutic value of drugs.
To know the Structure Activity Relationship (SAR) of different class of drugs.
To write the chemical synthesis of drugs.
Non-incised papillae surgical approach (NIPSA): A new technique for the treatment of deep intrabony defect: A case report
Authors: Patil Sharashchandra M , Kalluraya B Swasthik , Chambole Anjali , Tarannum Uzma , Naaz Farah 
Published: October 2024

: Periodontal regenerative therapy aims at the recovery of lost periodontal tissue due to disease. The management of intrabony defects in periodontal disease remains a significant clinical challenge, often requiring intricate surgical interventions. This study presents the Non-Incised Papilla Surgical Approach (NIPSA) as an innovative technique for effectively treating intrabony defects while preserving soft tissue architecture.: The aim of this case report on the Non-Incised Papillae Surgical Approach (NIPSA) technique is to effectively treat intrabony defects in periodontal therapy while minimizing surgical trauma and preserving soft and hard tissue architecture. NIPSA aims to achieve periodontal regeneration and clinical attachment gain through a minimally invasive approach, reducing patient discomfort and promoting predictable long-term outcomes. This case highlights the efficacy and patient satisfaction associated with the NIPSA technique in managing deep intrabony defects using bovine bone grafts. The outcome of this case resulted in post-operative healing was uneventful, with minimal discomfort reported by the patient. At the six-month follow-up, clinical examination revealed a significant clinical attachment gain, reduction in probing depth, and mobility, with no bleeding on probing. Radiographic evaluation demonstrated evidence of bone fill within the defect, indicating successful periodontal regeneration.: This case report offers a viable alternative for managing intrabony defects, providing effective treatment outcomes with minimal surgical trauma and enhanced patient satisfaction. Further research and long-term follow-up studies are needed to validate the efficacy and durability of this approach in periodontal therapy.
Praca – etyka – polityka
Authors: Walczak-Duraj Danuta 
Published: October 2024

Monografia stanowi zbiór wybranych tekstów Autorki z lat 2005–2019 dotyczących szeroko rozumianej pracy i polityki w kontekście etycznym. Zagadnienia te rozpatrywane są z perspektywy normatywnej – z punktu widzenia określonego, społecznego, w tym ekonomicznego, ładu aksjonormatywnego. Ważną kwestią są zmiany, jakie zachodzą w obszarze pracy i jej stosunków oraz w sposobie funkcjonowania współczesnych demokracji pod wpływem rozwoju technologii cyfrowych. Głównymi adresatami tej publikacji są: przedstawiciele nauk społecznych, ekonomicznych i politologicznych, a także studenci, organizatorzy życia gospodarczego i politycy. Książka z pewnością zainteresuje również szersze grono Czytelników, dla których problemy oraz przemiany współczesnej pracy i polityki są interesujące i ważne.
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Autorka […] wielokrotnie podkreśla, że każda forma ludzkiej aktywności, w tym […] praca w jej różnych odsłonach, również praca naukowca czy praca polityka, podlega ocenie etycznej, a kompetencje etyczne stanowią atrybutową cechę szeroko pojmowanych kompetencji merytorycznych.
Z przedmowy ks. prof. zw. dr. hab. Janusza Mariańskiego
O wyjątkowej wartości tej monografii stanowią […] aktualność i waga podejmowanych w niej kwestii społecznych. Dotyczy to zwłaszcza problemów związanych z deficytami etycznymi polityków funkcjonujących w formule liberalnych demokracji. […] do istotnych wątków rozważań Autorki zaliczam te, w których podkreśla, że pojawianie się […] cywilizacji algorytmów zmieni na przykład moralną przestrzeń pracy, a pracownicy być może staną przed wyzwaniem podejmowania transgresji etycznej w związku z rozwojem sztucznej, samouczącej się inteligencji.
Z recenzji prof. dr hab. Urszuli Swadźby
Editorial
Authors: Fernández Morales Flavio Humberto 
Published: October 2024

En esta ocasión quisiera compartir una breve reflexión sobre la discusión de los resultados y su importancia para un artículo científico, ya que es una de las principales causas de rechazo de los manuscritos en la fase de evaluación.

Es muy frecuente que los investigadores noveles a la hora de elaborar sus manuscritos, se limiten a describir los resultados, a veces de forma redundante, replicando la misma información en tablas y figuras e incluso en el propio texto, sin realizar la discusión respectiva. El documento elaborado de esta manera se constituye en un estudio de caso, limitando su interés a una comunidad muy reducida, usualmente la propia población objeto del estudio, ya sea una empresa, una institución educativa o una organización social, dependiendo de la temática tratada.

En este sentido, es necesario destacar que la discusión de los resultados corresponde al contraste de los hallazgos propios con los de otros investigadores, lo cual establece el carácter científico propiamente dicho de un artículo. No basta con describir los resultados y brindar la opinión sobre lo observado, sino que esas observaciones deben discutirse a la luz de lo reportado en la literatura, ya sea a favor o en contra de nuestros propios hallazgos.

En otras palabras, las hipótesis se verifican inicialmente a través del análisis de los resultados, y en una segunda instancia, a través del contraste de esos resultados con los publicados por otros investigadores. En síntesis, la discusión de los resultados de una investigación hacen crecer a la comunidad académica, aportando nuevas visiones a la investigación científica en una disciplina determinada.

En el presente fascículo, Vol. 14 No. 2, se incluyen doce artículos, los cuales invitamos a consultar y utilizar en sus trabajos académicos. Asimismo, se invita a los interesados en publicar los resultados de sus trabajos de investigación, a que envíen sus manuscritos a la revista. Los requisitos de forma se pueden consultar en nuestra página WEB, en el apartado de instrucciones para los autores, los cuales deben ser atendidos escrupulosamente para reducir los tiempos de evaluación.

Cordialmente,

FLAVIO HUMBERTO FERNÁNDEZ MORALES
Editor
Revista de Investigación, Desarrollo e Innovación
ISSN: 2027-8306 - ISSN-e: 2389-9417
Universidad Pedagógica y Tecnológica de Colombia
The Concept of Aswaja in the Thought of K. Abul Fadlol As-Senori (1916-1991 AD) and its Relationship with Aswaja in the Thought of KH. Hashim Ash`ari
Authors: Faizin Nur , Basid Abdul , Ramadhan Mochammad Rizal , Aliyyah Dza Himmatin , Nasih Ahmad Munjin , Marjuni Kamaluddin Nurdin 
Published: October 2024

The concept of <em>Ahlu </em><em>s</em><em>unnah wal </em><em>j</em><em>amaah</em> (<em>Aswaja</em>) remains a subject of frequent debate. This article endeavors to provide a comprehensive exploration of the <em>Aswaja</em> concept through the perspective of the archipelago scholar, K. Abu Fadlol As-Senori, a disciple of KH. Hashim Ash`ari, the founder of the Nahdlatul Ulama. This article also strives to establish a connection between the concept of <em>Aswaja</em> as it is found and the <em>Aswaja</em> concept of KH. Hashim Ash`ari. This research is a descriptive-qualitative study. This study revealed that <em>Aswaja</em>, as defined by K. Abul Fadlol, encompasses four distinct groups: (1) the <em>Muhadditsin</em>, (2) the <em>Sufiyyah</em> (3) the <em>Ash'ariyah</em> and (4) <em>Maturidiyah</em>. As a student of KH. Hashim Ash`ari, the <em>Aswaja</em> concept of K. Abul Fadlol has a very big aspect of similarity. The concept of <em>Aswaja</em> from both becomes the foundation for building moderation in religion. Both also reject hardline Islamists who claim to be <em>Aswaja</em>
Employer Demand and Desired Skills for Public Health Graduates: Evidence From Job Postings
Authors: Krasna Heather 
Published: October 2024

Objectives. To determine whether job postings from employers seeking master of public health (MPH) graduates require skills aligning with Council on Education in Public Health (CEPH) competencies. Methods. I analyzed a data set of 70 343 job postings in the United States for MPH graduates from Lightcast, a data vendor that collects, cleans, and analyzes millions of job postings per year. I contrasted skills from the postings with CEPH competencies. Results. Most postings were from for-profit industry, academia and research, or hospitals and health care, with only 12% from government. The skills from job postings aligned well with CEPH competencies, but some CEPH competencies did not appear in the top skills in job postings. Conclusions. Although accredited public health degree programs provide key competencies demanded by employers, they can improve graduate employability by ensuring that their graduates also obtain specific technical skills listed in job postings. ( Am J Public Health. 2024;114(12):1388–1393. https://doi.org/10.2105/AJPH.2024.307834 )
Influence of magnesium oxide expander on mechanical and shrinkage properties of UHPC incorporating recycled sand
Authors: Cheng Shukai , Liang Qianyong - , Liu Qiwen , Chen Kang , Wang Hongtao 
Published: October 2024

Abstract

The incorporation of MgO expansive agents and internal curing mechanisms has individually exhibited positive effects on mitigating shrinkage in Ultra-high performance concrete (UHPC), yet studies on their synergistic performance remain scarce. This paper explores the utilization of recycled sand as a substitute for quartz sand in UHPC production, incorporating various reactive (Type R and Type S) MgO expansive agents at concentrations of 4%, 6%, and 8% (by mass) into the recycled sand UHPC. The primary objective is to investigate the impacts of these MgO agents on the fluidity, mechanical properties, shrinkage behavior, chloride ion permeability, and the macroscopic and microscopic characteristics of the recycled sand UHPC. Utilizing Scanning Electron Microscopy (SEM), Thermogravimetric Analysis (TG), and Mercury Intrusion Porosimetry (MIP), we analyze the phase transformations, microscopic morphology, and pore structures of the recycled sand UHPC with different MgO expansive agents. Furthermore, we delve into the underlying mechanisms governing the effects of these MgO agents on the performance of recycled sand UHPC. The results reveal that both Type R and Type S MgO expansive agents reduce the fluidity, compressive strength, and chloride ion permeability of recycled sand UHPC, while significantly mitigating autogenous and drying shrinkages. Notably, Type R MgO demonstrates superior performance, reducing autogenous shrinkage by 26.4% after 7 days and drying shrinkage by 76.9% after 150 days. Microstructural analyses indicate that the highly reactive Type R MgO hydrates to form a greater amount of Mg(OH)2 crystals, which contributes to a decrease in porosity, particularly in pores smaller than 50nm, thereby enhancing the compactness of the UHPC matrix. Based on a comprehensive evaluation of workability, mechanical properties, and shrinkage behavior, the incorporation of Type R MgO expansive agent at an optimal dosage of 6% is recommended for recycled UHPC.
X-ray Inactivation of SARS-CoV-2: A Safe, Cost-effective Approach for Pandemic Testing Workflows.
Authors: Campbell Elle , Afrough Babak , Bonney Laura , Curran-French Mollie , Chamberlain John , Daddiego Jake , Fotheringham Verity , Stanley Megan , Drinkwater Ellie , Ferreira Pedro , Tolley Howard , Dugg Sahil , Burton Jane , Easterbrook Linda , Hewson Roger 
Published: October 2024

Abstract

In response to the unprecedented challenges posed by the COVID-19 pandemic, this study introduces a novel application of X-ray irradiation to rapidly inactivate SARS-CoV-2 variants, enabling safe and efficient virus handling outside high-containment facilities. Unlike traditional methods, X-ray irradiation preserves both the structural and genomic integrity of the virus, allowing for accurate detection through molecular and antigen-based diagnostics. Our findings not only demonstrate the method's superiority over gamma irradiation in terms of safety and cost but also its effectiveness in maintaining antigenic fidelity, critical for diagnostic reliability. Importantly, the scalability and accessibility of X-ray technology provide a transformative approach for managing future pandemic outbreaks, offering a robust tool for rapid viral inactivation that can significantly enhance global testing and research capabilities without the logistical and safety constraints of high-containment processing.
Newly synthesized 1,2,3-triazoles based on [1,4]-benzoxazin- 3-one: In silico evaluation of anti-inflammatory, antibacterial, antioxidant, anticancer, and antidiabetic properties, along with molecular dynamics simulation and ADME analysis
Authors: Addichi Darifa , Farihi Ayoub , Hachimi Noufel , Loughmari Saliha , Alqahtani Ali S. , Ihammi Aziz , Noman Omar M. , Bouhrim Mohamed , Ed-Dra Abdelaziz , Eto Bruno , Ellouz Mohamed , Chigr Fatiha , Chigr Mohammed 
Published: October 2024

Abstract

Based on the significant biological activity of benzoxazines and 1,2,3-triazoles, we aim to combine these active moieties to design and synthesize new compounds and evaluate their biological activity. In this context, we present the synthesis of new 1,2,3-triazoles, specifically 1,4-disubstituted, in combination with [1,4]-benzoxazin-3-one. To synthesize the target compounds, the 1,3-dipolar Huisgen cycloaddition is used as a central step. This reaction occurs between ethyl azidoacetate and the terminal alkyne of [1,4]-benzoxazin-3-one under catalytic conditions using Cu(I) (CuAAC). Followed by the condensation of hydrazine on the ester function and then a reaction with various aromatic aldehydes to form the corresponding hydrazones (4a–4j). Molecular docking revealed that the synthesis molecules exhibited potential antidiabetic, anti-inflammatory, anticancer, antibacterial, and antioxidant properties. Among them, 4a showed the highest affinity for these activities and 4b showed the highest affinity for antioxidant activity. To further evaluate its potential, 4a and 4b underwent molecular dynamics (MD) simulations over a 5 ns period. The stability and flexibility of the 4a-3W2S and 4b-3DK9 complex were evaluated using RMSF, RMSD, H-Bond, and Rg analyses, revealing notable interaction stability and flexibility. In addition, ADME analysis demonstrated favorable pharmacokinetic properties and oral absorption of the synthetic molecules, meeting the Lipinski and Veber criteria and suggesting their potential as oral drug candidates. This comprehensive assessment highlights the value of these novels [1,4]-benzoxazin-3-one derivatives and supports further research exploring their therapeutic potential.
Establishment of recommendation domains for the fertilization of Arabica coffee plantations in the province of Manabí, Ecuador
Authors: Reyes-Pilay Carlos Javier , Duicela-Guambi Luis Alberto , Fosado-Téllez Osvaldo Alberto , Hector-Ardisana Eduardo Fidel 
Published: October 2024

Abstract

Aims
To determine the nutrient contents, organic matter, and acidity levels in soil samples from various coffee-growing localities in the province of Manabí, Ecuador, and to identify the critical chemical elements that allow for the differentiation of Arabica coffee soils to determine recommendation domains according to similarities of these soils.
Methods
A total of 251 soil samples were analyzed, taken from producing coffee plantations in seven cantons and 16 parishes of the province. The factors studied were: acidity level (pH), organic matter (%), and nutrient contents. The chemical variables were: pH, organic matter, N, P, K, Ca, Mg, S, Fe, Cu, Mn, Zn, and B. Using acidity level as the primary classification criterion and multivariate statistical methods, the coffee plantations were grouped.
Results
Deficiencies in nitrogen, sulfur, zinc, and boron prevail in most of the farms studied, and farms were grouped on these bases and the acidity of soils, according with the recommended for coffee plantations. From these groupings, seven recommendation domains were established for the fertilization of coffee plantations.
Conclusions
These criteria can be applied to the implementation of orderly and fair fertilization plans, which would help achieve more efficient fertilizer management based on the actual needs of the plantations, causing less harm to the environment.