bluuebunny/crossref_metadata_2025_split huggingface dataset:
Espaço, saber e poder: Foucault e a geografia
Authors: Leite de Barros Ana Maria , Zanotelli Claudio 
Published: July 2016

Texto traduzido livremente do original em inglês: Space, knowledge and power: Foucault and geography (páginas 41 a 64).Editado por Jeremy W. Crampton e Stuart Elden. Ashgate Publishing Limited, 2007.Os textos aqui agrupados correspondem às respostas de geógrafos anglo-saxões efetuadas trinta anos depois às questões formuladas por Foucault à revista Hérodote (Abril-junho, segundo trimestre de 1977, n.6, p.3-39). Essas questões e respostas de Foucault datando de 1977 e traduzidas estão sendo publicadas nesse mesmo número da Geografares.Dentre essas respostas à Foucault com trinta anos de intervalo, há notadamente um texto de David Harvey. Desse modo, podemos avaliar as diferentes recepções e comentários às questões e à obra de Michel Foucault, feitas com trinta anos de intervalo por geógrafos de matrizes teóricas distintas.
[Budget impact analysis for peginterferon beta-1a in relapsing remitting multiple sclerosis in Italy]
Authors: Iannazzo Sergio , Santoni Laura , Saleri Cecilia , Puma Elisa , Vestri Giulia , Giuliani Luigi , Centonze Diego , Canonico Pier Luigi 
Published: July 2016

BACKGROUND: Peginterferon beta-1a, injected every two weeks, is the first approved pegylated interferon beta-1a for the treatment of relapsing remitting multiple sclerosis (RRMS). The objective of this analysis was to estimate the economic impact due to the introduction of peginterferon beta-1a in Italy.METHODS: This analysis was conducted with a three-year time horizon with the support of a simple decision-analytic model adopting the perspective of the Italian National Healthcare Service (NHS). Healthcare costs sustained by the Italian NHS to manage the RRMS population (drug treatment, monitoring, relapse management, adverse events management) were calculated over 3 years and compared in two scenarios: the base scenario where interferons-beta and glatiramer acetate (GA) are used to treat RRMS patients, and an alternative scenario where peginterferon beta-1a can also be used to treat RRMS patients. The target population was approximately 35,500, 37,500 and 39,500 patients at year 1, 2 and 3 respectively, based on the published literature and market data. The efficacy of treatments was simulated as a reduction of relapse rates and was derived from a Network Meta-analysis. Unit costs were based on current prices and tariffs, and the published literature. A one-way sensitivity analysis was developed.RESULTS: According to current price and described assumptions, it was estimated that the introduction of peginterferon beta-1a would result in a decrease of total costs when compared with the base scenario. The cost in the base scenario was estimated to be € 321.5, € 339.7 and € 357.8 million in years 1, 2, and 3, respectively. In the alternative scenario, the same costs resulted in about € 321.1, € 338.6 and € 356.2 million, respectively. The cumulative budget impact over three years period was approximately a cost saving of € 3.1 million (about 0.3% saving).CONCLUSION: The adoption of peginterferon beta-1a for the treatment of RRMS would be viewed as economically sustainable by the Italian NHS.[Article in Italian]
New constraints on deglacial marine radiocarbon anomalies from a depth transect near Baja California
Authors: Lindsay Colin M. , Lehman Scott J. , Marchitto Thomas M. , Carriquiry José D. , Ortiz Joseph D. 
Published: July 2016

AbstractPrevious studies have shown that radiocarbon activities (Δ14C) in the low‐latitude, middepth Pacific and Indian Oceans were anomalously low during Heinrich Stadial 1 (HS1, ~17.8–14.6 ka) and the Younger Dryas (YD, ~12.8–11.5 ka), coincident with intervals of rising atmospheric CO2 concentration and declining atmospheric Δ14C. However, a full explanation of these events remains elusive due to sparse and sometimes conflicting data. Here we present new 14C measurements on benthic and planktic foraminifera that, in combination with previously published measurements, enable us to reconstruct the Δ14C depth gradient near Baja California. Vertical profiles were similar to present during the Last Glacial Maximum and Bølling/Allerod (14.6–12.8 ka) but display a pronounced middepth (~700 m) Δ14C minimum during HS1 and the YD. The latter observation, along with a comparison to other regional reconstructions, appears to rule out intermediate waters from the north or from directly below as proximate sources of aged 14C‐depleted ocean carbon during deglaciation and point instead to changes in the composition of Equatorial Pacific intermediate waters. Simple mixing constraints require Equatorial Pacific intermediate waters to be only slightly lower in Δ14C than at Baja California, in contrast with previous observations of extremely low Δ14C at Galapagos Rise. While the latter may have been influenced by localized releases of geologic (14C‐dead) CO2, the smaller and more widespread deglacial Δ14C anomalies in the Arabian Sea and North Pacific seem to require a source of aged carbon in the glacial deep Southern and Pacific Oceans for which there is growing evidence.
An integrated analysis of the March 2015 Atacama floods
Authors: Wilcox Andrew C. , Escauriaza Cristian , Agredano Roberto , Mignot Emmanuel , Zuazo Vicente , Otárola Sebastián , Castro Lina , Gironás Jorge , Cienfuegos Rodrigo , Mao Luca 
Published: July 2016

AbstractIn March 2015 unusual ocean and atmospheric conditions produced many years' worth of rainfall in a ~48 h period over northern Chile's Atacama Desert, one of Earth's driest regions, resulting in catastrophic flooding. Here we describe the hydrologic and geomorphic drivers of and responses to the 2015 Atacama floods. In the Salado River, we estimated a flood peak discharge of approximately 1000 m3/s, which caused widespread damage and high sediment loads that were primarily derived from valley‐fill erosion; hillslopes remained surprisingly intact despite their lack of vegetation. In the coastal city of Chañaral, flooding of the Salado River produced maximum water depths over 4.5 m, meters thick mud deposition in buildings and along city streets, and coastal erosion. The Atacama flooding has broad implications in the context of hazard reduction, erosion of contaminated legacy mine tailings, and the Atacama's status as a terrestrial analog for Mars.
GPS velocities and the construction of the Eastern Cordillera of the Colombian Andes
Authors: Mora‐Páez Héctor , Mencin David J. , Molnar Peter , Diederix Hans , Cardona‐Piedrahita Leonardo , Peláez‐Gaviria Juan‐Ramón , Corchuelo‐Cuervo Yuli 
Published: July 2016

AbstractGPS velocities across the northeast trending Eastern Cordillera of Colombia show oblique convergence at 8.8 ± 1.7 mm/yr, consisting of 8.0 ± 1.7 mm/yr of right‐lateral strike‐slip shear along the mountain range and 3.7 ± 0.3 mm/yr of northwest southeast shortening. Faster convergence occurs only at the northeast end of the Cordillera, where its eastern edge trends northwest and the highest mountains lie. The strike‐slip shear corroborates geologic work suggesting such movement southwest and northeast of the range. Given the ~200 km width of the Eastern Cordillera, the ~100–150 km of crustal shortening inferred from balanced cross sections and implied by recent estimates of crustal thickness would require ~25–40 Myr of shortening at ~4 mm/yr. The present‐day GPS measurements, therefore, are inconsistent with the inference, based on paleobotanical observations that the entire Eastern Cordillera rose 1500–2500 m since 3–6 Ma and called for a different interpretation of those data.
Micropatterning of the Ferroelectric Phase in a Poly(vinylidene difluoride) Film by Plasmonic Heating with Gold Nanocages
Authors: Li Jianhua , Yang Miaoxin , Sun Xiaojun , Yang Xuan , Xue JiaJia , Zhu Chunlei , Liu Hong , Xia Younan 
Published: July 2016

AbstractPolymer thin films with patterned ferroelectric domains are attractive for a broad range of applications, including the fabrication of tactile sensors, infrared detectors, and non‐volatile memories. Herein, we report the use of gold nanocages (AuNCs) as plasmonic nanostructures to induce a ferroelectric–paraelectric phase transition in a poly(vinylidene fluoride) (PVDF) thin film by leveraging its photothermal effect. This technique allows us to generate patterned domains of ferroelectric PVDF within just a few seconds. The incorporation of AuNCs significantly enhances the pyroelectric response of the ferroelectric film under near‐infrared irradiation. We also demonstrate the use of such patterned ferroelectric films for near‐infrared sensing/imaging.
Effect of in situ apatite on performance of collagen fiber film for food packaging applications
Authors: Wang Wenhang , Liu Yaowei , Liu Anjun , Zhao Yana , Chen Xin 
Published: July 2016

ABSTRACTThis study attempted to prepare apatite in situ in acid‐swollen cowhide collagen film by an ammonia gas fumigating method and assess its reinforcement effect on a collagen fiber film for food packaging applications. The X‐ray diffraction and Fourier transform infrared spectroscopy results confirmed the successful synthesis of apatite in collagen fiber films. SEM images showed that tiny apatite particles appeared as a coating on the film surface and also made the film's inner structure more compact and less porous than pure collagen fiber film. Apatite significantly (p < 0.05) increased the tensile strength and improved the water vapor barrier and water insolubility properties of collagen fiber film. Moreover, the thermogravimetric and differential scanning calorimetry results confirmed that the thermal stability of collagen was improved with the increasing apatite. The in situ–synthesized apatite provided a practical reinforcement approach to improving the collagen fiber film's performance and benefited its application as a food packaging material. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44154.
Oxime crosslinked polymer networks: Is every reversible covalent bond suitable to create self‐healing polymers?
Authors: Kuhl Natascha , Abend Marcus , Bode Stefan , Schubert Ulrich S. , Hager Martin D. 
Published: July 2016

ABSTRACTThe incorporation of reversible covalent bonds into polymeric materials offers the possibility to generate polymers with self‐healing ability. For this purpose, three new oxime crosslinkers are synthesized and crosslinked by the copolymerization with different commercially available methacrylates via a photo‐polymerization process. These crosslinked materials are investigated regarding a potential self‐healing behavior. Moreover, the influence of different additives (polymerizable acids, photo acids, and acid developers) to enable self‐healing is studied in detail. Thereby, the limit of self‐healing based on reversible covalent bonds is reached in these materials. Due to the high stability of the oxime bonds in bulk materials no exchange reactions as well as no self‐healing behavior could be observed. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44168.
Zwitterionic‐polymer‐functionalized poly(vinyl alcohol‐co‐ethylene) nanofiber membrane for resistance to the adsorption of bacteria and protein
Authors: Wang Wenwen , Lu Ying , Luo Mengying , Zhao Qinghua , Wang Yuedan , Liu Qiongzhen , Li Mufang , Wang Dong 
Published: July 2016

ABSTRACTA zwitterionic poly(vinyl alcohol‐co‐ethylene) (PVA‐co‐PE) nanofiber membrane for resistance to bacteria and protein adsorption was fabricated by the atom transfer radical polymerization of sulfobetaine methacrylate (SBMA). The PVA‐co‐PE nanofiber membrane was first surface‐activated by α‐bromoisobutyryl bromide, and then, zwitterionic SBMA was initiated to polymerize onto the surface of nanofiber membrane. The chemical structures of the functionalized PVA‐co‐PE nanofiber membranes were confirmed by attenuated total reflectance–Fourier transform infrared spectroscopy and X‐ray photoelectron spectroscopy. The morphologies of the PVA‐co‐PE nanofiber membranes were characterized by scanning electron microscopy. The results show that the poly(sulfobetaine methacrylate) (PSBMA) was successfully grafted onto the PVA‐co‐PE nanofiber membrane, and the surface of the nanofiber membrane was more hydrophilic than that of the pristine membrane. Furthermore, the antibacterial adsorption properties and resistance to protein adsorption of the surface were investigated. This indicated that the PSBMA‐functionalized surface possessed good antibacterial adsorption activity and resistance to nonspecific protein adsorption. Therefore, this study afforded a convenient and promising method for preparing a new kind of soft and nonwoven dressing material with antibacterial adsorption and antifouling properties that has potential use in the medical field. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44169.
Hexa‐peri‐hexabenzocoronene with Different Acceptor Units for Tuning Optoelectronic Properties
Authors: Keerthi Ashok , Hou Ian Cheng‐Yi , Marszalek Tomasz , Pisula Wojciech , Baumgarten Martin , Narita Akimitsu 
Published: July 2016

AbstractHexa‐peri‐hexabenzocoronene (HBC)‐based donor–acceptor dyads were synthesized with three different acceptor units, through two pathways: 1) “pre‐functionalization” of monobromo‐substituted hexaphenylbenzene prior to the cyclodehydrogenation; and 2) “post‐functionalization” of monobromo‐substituted HBC after the cyclodehydrogenation. The HBC–acceptor dyads demonstrated varying degrees of intramolecular charge‐transfer interactions, depending on the attached acceptor units, which allowed tuning of their photophysical and optoelectronic properties, including the energy gaps. The two synthetic pathways described here can be complementary and potentially be applied for the synthesis of nanographene–acceptor dyads with larger aromatic cores, including one‐dimensionally extended graphene nanoribbons.
Do androgen deprivation and the biologically equivalent dose matter in low‐dose‐rate brachytherapy for intermediate‐risk prostate cancer?
Authors: Tabata Ryuji , Kimura Takahiro , Kuruma Hidetoshi , Sasaki Hiroshi , Kido Masahito , Miki Kenta , Takahashi Hiroyuki , Aoki Manabu , Egawa Shin 
Published: July 2016

AbstractThe objective of this study was to investigate the impact of the biologically equivalent dose (BED) on treatment outcomes after iodine‐125 low‐dose‐rate brachytherapy (LDR‐BT) with or without supplemental external beam radiotherapy (EBRT) and androgen deprivation therapy (ADT) for intermediate‐risk prostate cancer (PCa). We retrospectively evaluated 292 Japanese patients. The impact of the BED and ADT on treatment outcomes was investigated. Cox proportional hazard models were used for univariate and multivariate analysis with biological progression‐free survival (bPFS) and clinical progression‐free survival (cPFS) as the primary outcome measures. The median follow‐up was 66 months. The bPFS and cPFS rates at 5‐/7‐years were 91.6/87.7% and 95.9/94.0%, respectively. When stratified by BED levels, the bPFS rates at 5‐/7‐years were 92.1/89.3% for <178.0 Gy2, and 91.2/86.0% for ≥178.0 Gy2, respectively (P > 0.05). Based on ADT duration, the bPFS rates at 5‐/7‐years were 89.8/83.5%, 89.7/89.7%, and 97.5/97.5% for none, 1–3 months, and 4–12 months, respectively (P = 0.03). For the univariate analysis, the use of ADT and its duration were significant predictors for bPFS, whereas BED was not significant. A multivariate analysis did not indicate the use of ADT itself was significant, however, when covariates were accounted for by the duration of ADT, the longer use of ADT was found to significantly improve bPFS. Although cPFS was associated neither with the BED levels nor ADT duration (P > 0.05), ADT duration had a trend of improving cPFS (P = 0.053). The higher levels of BED did not significantly impact bPFS for intermediate‐risk PCa after LDR‐BT with or without supplemental EBRT and ADT. The longer duration of ADT could provide an additional benefit in the context of high‐dose irradiation generated by LDR‐BT.
Ruthenium(II)‐Catalyzed Traceless C−H Functionalization Using an N−N Bond as an Internal Oxidant
Authors: Zhou Shuguang , Wang Jinhu , Chen Pei , Chen Kehao , Zhu Jin 
Published: July 2016

AbstractA previously elusive RuII‐catalyzed N−N bond‐based traceless C−H functionalization strategy is reported. An N‐amino (i.e., hydrazine) group is used for the directed C−H functionalization with either an alkyne or an alkene, affording an indole derivative or olefination product. The synthesis features a broad substrate scope, superior atom and step economy, as well as mild reaction conditions.
Stress Cardiac MRI in Women With Myocardial Infarction and Nonobstructive Coronary Artery Disease
Authors: Mauricio Rina , Srichai Monvadi B. , Axel Leon , Hochman Judith S. , Reynolds Harmony R. 
Published: July 2016

BackgroundIn a prospective study, cardiac MRI (CMR) and intravascular ultrasound were performed in women with myocardial infarction (MI) and nonobstructive coronary artery disease (MINOCA). Forty participants underwent adenosine‐stress CMR (sCMR).HypothesisAbnormal perfusion may co‐localize with ischemic late gadolinium enhancement (LGE) and T2‐weighted signal hyperintensity (T2+), suggesting microvascular dysfunction contributed to MI.MethodsQualitative perfusion analysis was performed by 2 independent readers. Abnormal myocardial perfusion reserve index (MPRI) was defined as global average ≤1.84.ResultsAbnormal rest perfusion was present in 10 patients (25%) and stress perfusion abnormalities in 25 (63%). Abnormal stress perfusion was not associated with LGE but tended to occur with T2+. Among patients with abnormal perfusion and LGE, the LGE pattern was ischemic in half. The locations of abnormal perfusion and LGE matched in 75%, T2+ in 100%. Abnormal stress perfusion was not associated with plaque disruption and matched in location in 63%. MPRI was abnormal in 10 patients (25%) and was not associated with LGE, T2+ or plaque disruption.ConclusionsAbnormal perfusion on sCMR is common among women with MINOCA. Abnormal perfusion usually co‐localized with LGE and/or T2+ when present. Variability in LGE pattern leads to uncertainty about whether the finding of abnormal perfusion was cause or consequence of the tissue state leading to LGE. Low MPRI, possibly indicating diffuse microvascular disease, was observed with and without LGE and T2+. Multiple mechanisms may lead to abnormal perfusion on sCMR. Microvascular dysfunction may contribute to the pathogenesis of and coexist with other causes of MINOCA.
Similar Impact of Clopidogrel or Ticagrelor on Carotid Atherosclerotic Plaque Inflammation
Authors: Oh Minyoung , Lee Cheol Whan , Lee Hyo Sang , Chang Mineok , Ahn Jung‐Min , Park Duk‐Woo , Kang Soo‐Jin , Lee Seung‐Whan , Kim Young‐Hak , Moon Dae Hyuk , Park Seong‐Wook , Park Seung‐Jung 
Published: July 2016

BackgroundPlatelets play an important role in inflammation. Inhibitors of the P2Y12
receptor, which is involved in platelet activation, may have a direct effect on carotid atherosclerotic plaque inflammation.HypothesisWe compared the effects of clopidogrel and ticagrelor therapy for carotid atherosclerotic plaque inflammation using
18F‐fluorodeoxyglucose (
18FDG) positron emission tomography (PET) imaging.MethodsFifty patients with acute coronary syndrome and ≥1
18FDG uptake in the carotid artery (target‐to‐background ratio [TBR] ≥1.6) were randomized to either clopidogrel or ticagrelor groups. Of these, 46 completed PET examinations at baseline and at 6 months. The primary endpoint was the percent change in TBR of the index vessel at the most diseased segment (MDS).ResultsBaseline characteristics were similar between the 2 groups. At 6‐month follow‐up, low‐density lipoprotein cholesterol and C‐reactive protein significantly decreased in both groups (P < 0.001). The TBR of the index vessel and aorta significantly decreased in both groups (P < 0.01). The percent change in the MDS TBR of the index vessel was numerically but not significantly lower in the clopidogrel group than in the ticagrelor group (−9.5 ± 14.6% vs −13.5 ± 19.3%; P = 0.427). Likewise, the percent change in the whole‐vessel TBR of the index vessel was not different between the 2 groups (P = 0.166). Similar findings were observed for changes in the MDS TBR (P = 0.412) or whole‐vessel TBR of the aorta (P = 0.363).ConclusionsCarotid atherosclerotic plaque inflammation significantly decreases to a similar degree following 6 months of either clopidogrel or ticagrelor treatment.
TP53 mutations in newly diagnosed acute myeloid leukemia: Clinicomolecular characteristics, response to therapy, and outcomes
Authors: Kadia Tapan M. , Jain Preetesh , Ravandi Farhad , Garcia‐Manero Guillermo , Andreef Michael , Takahashi Koichi , Borthakur Gautam , Jabbour Elias , Konopleva Marina , Daver Naval G. , Dinardo Courtney , Pierce Sherry , Kanagal‐Shamanna Rashmi , Patel Keyur , Estrov Zeev , Cortes Jorge , Kantarjian Hagop M. 
Published: July 2016

BACKGROUNDMutations in the tumor protein 53 (TP53) gene predict a poor prognosis in patients with acute myeloid leukemia (AML).METHODSPeripheral blood or bone marrow samples from 293 patients with newly diagnosed AML were analyzed with targeted, amplicon‐based, next‐generation sequencing‐based mutation analysis.RESULTSTP53 mutations were identified in 53 patients (18%; 45 were missense mutations). In 13 of the 53 patients, the most common pattern of amino acid substitution was a substitution of arginine to histidine on different codons. The clinical characteristics, pattern of mutations, response to different therapies, and outcomes of patients with AML‐TP53–mutated (n = 53) versus wild‐type TP53 (n = 240) were compared. TP53 mutations were significantly more likely in patients who had a complex karyotype; abnormalities of chromosome 5, 7, and 17; and therapy‐related AML. Patients who had TP53‐mutated AML had significantly lower incidence of mutations in Fms‐like tyrosine kinase 3 (FLT3), rat sarcoma (RAS), and nucleophosmin (NPM1) and higher incidence of coexisting MPL mutations compared with those who had wild type TP53. The distribution of TP53 mutations was equal for both age groups (ages <60 years vs ≥60 years). TP53‐mutated AML was associated with a lower complete remission rate (41% vs 57%; P = .04), a significantly inferior complete remission duration (at 2 years: 30% vs 55%; P = .001), and overall survival (at 2 years: 9% vs 24%; P ≤ .0001) irrespective of age or the type of treatment received (high‐intensity vs low‐intensity chemotherapy).CONCLUSIONSThe type of treatment received did not improve outcomes in younger or older patients with TP53‐mutated AML. These data suggest that novel therapies are needed to improve the outcome of patients with AML who have TP53 mutations. Cancer 2016;122:3484–3491. © 2016 American Cancer Society
Track fusion based on threshold factor classification algorithm in wireless sensor networks
Authors: Wang Xiang , Wang Tao , Chen Shiyang , Fan Renhao , Xu Yang , Wang Weike , Li Hongge , Xia Tongsheng 
Published: July 2016

SummaryTraditional tracking classification algorithm has been widely applied to target tracking in wireless sensor networks. In this paper, focusing on the accuracy of target tracking in wireless sensor networks, we propose an improved threshold factor track classification algorithm. The algorithm extracts the motion model according to the intrinsic properties of the target. It updates the iterative center according to the real‐time motion state of the moving target and timely filters out the weak correlated or uncorrelated data. In order to show the improved threshold factor classification algorithm is more effective, we compare the proposed algorithm with the classification algorithm based on the Euclidean distance comprehensive function. Experimental results show that through the proposed algorithm, the mean error and variance in the direction of x/y/z have been reduced to a certain extent, and the computation time consumed is also reduced. Copyright © 2016 John Wiley & Sons, Ltd.