bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viral surveillance using PCR during treatment of AML and ALL
Authors: Dixon Stephanie B. , Lane Adam , O'Brien Maureen M. , Burns Karen C. , Mangino Jennifer L. , Breese Erin H. , Absalon Michael J. , Perentesis John P. , Phillips Christine L. 
Published: August 2017

AbstractBackgroundWhile viral surveillance of cytomegalovirus (CMV), Epstein–Barr virus (EBV), and adenovirus using PCR is routine in patients undergoing hematopoetic stem cell transplant and solid organ transplant, the utility in the nontransplant pediatric leukemia population is unknown. Our institution screens patients with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) for viral DNAemia by PCR as part of clinical care.ProcedureThis retrospective chart review included patients treated for newly diagnosed or relapsed AML or ALL between April 2010 and September 2014. We retrieved data for viral PCR screening, detection and quantification, duration of positivity, and prophylaxis or treatment.ResultsOne hundred eleven patients were included in analyses. Forty (36.0%) had at least one blood PCR positive for EBV, CMV, or adenovirus. Patients with ALL had significantly higher rates of persistent viral detection and treatment than those with AML (P< 0.02,P< 0.01, respectively). International patients had significantly higher rates of viral detection (P< 0.01), persistence (P< 0.01), any treatment (P< 0.03), and antiviral treatment (P< 0.01); 16.9% of patients who received intravenous immunoglobulin (IVIG) prophylactically had viral detection compared to 63% of patients who did not receive prophylactic IVIG (P= 0.0008).ConclusionsPatients with ALL were more susceptible than those with AML to viral reactivation that was persistent or resulted in treatment. Patients with relapsed ALL, refractory ALL, or infantile ALL are most likely to benefit from asymptomatic screening for CMV and adenovirus. International patients are at higher risk for reactivation and may merit screening. EBV reactivation was not significant and does not warrant screening.
Comparing oncologic outcomes after minimally invasive and open surgery for pediatric neuroblastoma and Wilms tumor
Authors: Ezekian Brian , Englum Brian R. , Gulack Brian C. , Rialon Kristy L. , Kim Jina , Talbot Lindsay J. , Adibe Obinna O. , Routh Jonathan C. , Tracy Elisabeth T. , Rice Henry E. 
Published: August 2017

AbstractBackgroundMinimally invasive surgery (MIS) has been widely adopted for common operations in pediatric surgery; however, its role in childhood tumors is limited by concerns about oncologic outcomes. We compared open and MIS approaches for pediatric neuroblastoma and Wilms tumor (WT) using a national database.MethodsThe National Cancer Data Base from 2010 to 2012 was queried for cases of neuroblastoma and WT in children ≤21 years old. Children were classified as receiving open or MIS surgery for definitive resection, with clinical outcomes compared using a propensity matching methodology (two open:one MIS).ResultsFor children with neuroblastoma, 17% (98 of 579) underwent MIS, while only 5% of children with WT (35 of 695) had an MIS approach for tumor resection. After propensity matching, there was no difference between open and MIS surgery for either tumor for 30‐day mortality, readmissions, surgical margin status, and 1‐ and 3‐year survival. However, in both tumors, open surgery more often evaluated lymph nodes and had larger lymph node harvest.ConclusionOur retrospective review suggests that the use of MIS appears to be a safe method of oncologic resection for select children with neuroblastoma and WT. Further research should clarify which children are the optimal candidates for this approach.
Longitudinal parental preferences for late effects communication during cancer treatment
Authors: Sisk Bryan A. , Greenzang Katie A. , Kang Tammy I. , Mack Jennifer W. 
Published: August 2017

AbstractFew studies have investigated parent preferences for late effects communication during pediatric cancer treatment. We used questionnaire data to assess whether parental preferences for late effects information change over the year after diagnosis. Most parents found this information to be very/extremely important at baseline, assessed soon after diagnosis, (94%, 153/162), 4 months (91%, 147/162), and 12 months (96%, 156/163). Similarly, most parents wanted as much detail as possible about late effects at baseline (85%, 141/165), 4 months (87%, 144/165), and 12 months (83%, 137/165). Parents of children with favorable prognoses preferred more details at baseline (OR 2.94, 1.18–7.31, P = 0.02) than parents whose children had less favorable prognoses.
Synthesis, Characterization of Bicarbazole Compounds and Their Application in Codepositing Luminescent Copper Iodide Complexes
Authors: Rui Bin , Tan Yu , Liu Xiaochen , Wei Chen , Liu Yang , Li Jiayi , Liu Zhiwei , Bian Zuqiang , Huang Chunhui 
Published: August 2017

AbstractEight bicarbazole (BCz) compounds, 9,9′‐diphenyl‐3,3′‐bicarbazole (PhBCz), 9,9′‐di(2‐pyridyl)‐3,3′‐bicarbazole (o‐PyBCz), 9,9′‐di(3‐pyridyl)‐3,3′‐ bicarbazole (m‐PyBCz), 9,9′‐di(4‐pyridyl)‐3,3′‐bicarbazole (p‐PyBCz), 9,9′‐di(5‐pyrimidinyl)‐3,3′‐bicarbazole (PmBCz), 9,9′‐di(2‐pyrazinyl)‐3,3′‐bicarbazole (PzBCz), 9,9′‐di(4‐isoquinolinyl)‐3,3′‐bicarbazole (4‐IqBCz), and 9,9′‐di(5‐isoquinolinyl)‐3,3′‐bicarbazole (5‐IqBCz), that can be divided into three categories: category one with ortho, meta, or para pyridyl substituted BCz (PhBCz as a reference), category two with pyrimidinyl or pyrazinyl substituted BCz, and category three with 4‐ or 5‐isoquinolinyl substituted BCz, were synthesized and characterized in terms of photophysical, thermal, and electrochemical properties. Moreover, these compounds were utilized to codepositing with copper iodide to form luminescent copper iodide complex doped films in situ, whose emission colors range from green to yellow and might be employed as the emissive layer in organic light‐emitting diodes (OLEDs).
Synthesis of a Naturally Occurring Plant Alkaloid Berberine Analogue and Its Application in Nanomolar Selective Detection of Hydrazine in Free and DNA‐Binding Situation.
Authors: Jana Gopal C. , Nayim Sk , Khatun Munira , Das Somnath , Patra Anirudha , Sahoo Nandan K. , Jha Pradeep K. , Mandal Samir , Chaudhuri Keya , Hossain Maidul 
Published: August 2017

AbstractA sensitive platform for in vivo selective detection of the toxic element by a DNA stabilized biomolecule is of great importance. Particularly sensing of hydrazine in the presence of DNA is very important during cell damage and post‐mortem. In this study, a new 9‐O‐(4‐nitrobenzoyl) berberine analogue was designed and synthesized. The Calf thymus DNA (CT‐DNA) binding affinity studies revealed that the analogue was excellent DNA binding efficacy with groove binding mode (K= 4.2 × 106 M−1) compared to parent berberine (K= 2.2 ×105 M−1). Importantly, our synthesized analogue for the first time a berberine analogue that can effectively use as a selective ratiometric colorimetric probe for hydrazine detection based on ICT (intramolecular charge transfer) mechanism with a good limit of detection (20nM) which is much below the threshold limiting value (TLV) of hydrazine (10 ppb or 312 nM) as regulated by Environmental protection agency (EPA). Interestingly, we report a new avenue in sensing study in the presence of DNA i. e. our DNA groove binding analogue (at maximum saturation) also can serve as a promising turn on fluorimetric sensor for hydrazine detection with high selectivity over biologically abundant amines and metal cations with well limit of detection (LOD) value (14 nM). The sensing mechanism in the absence of DNA and in the presence of DNA was established by different spectroscopic methods. In addition, the berberine analogue could also be utilized for qualitative detection of hydrazine in the vapor phase and for the imaging of hydrazine in living Michigan Cancer Foundation‐7 (MCF‐7) cells.
Development of a L‐Tryptophan‐Based Ligand for Regioselective Copper Catalyzed N2‐Arylation of 1,2,3‐Triazoles
Authors: Lopes Alexandra Basilio , Wagner Patrick , Kümmerle Arthur Eugen , Bihel Frédéric , Bourguignon Jean‐Jacques , Schmitt Martine , Miranda Leandro S. M. 
Published: August 2017

Abstract2‐aryl‐1,2,3‐triazoles are important compounds that find applications in Medicinal chemistry, diagnostics, catalysis and others. However, only few methodologies for their preparation is found in the literature. The development of a post cycloaddition N2 selective arylation towards these compounds would benefit from a more convergent strategy. In the present communication, the development of a new tryptophan‐based ligand allowed the selective arylation of the N2‐position of 1,2,3‐triazoles using recyclable CuFe2O4 nanoparticles. This method was efficient in furnishing N2‐arylated and heteroarylated 1,2,3‐triazoles in good yields and excellent N2‐selectivity. The methodology developed found application in the synthesis of the 2‐aryl‐1,2,3‐triazoyl fragment of the drug suvorexant (Belsomra®).
Analysis of outrigger numbers and locations in outrigger braced structures using a multiobjective genetic algorithm
Authors: Chen Yue , Zhang Zhenya 
Published: August 2017

SummaryDue to its advantages, the outrigger braced system has been employed in high‐rise structures for the last 3 decades. It is evident that the numbers and locations of outriggers in this system have a crucial impact on the performance of high‐rise buildings. In this paper, a multiobjective genetic algorithm (MGA) is applied to an existing mathematical model of outrigger braced structures and a practical project to achieve Pareto optimal solutions, which treat the top drift and core base moment of a high‐rise building as 2 trade‐off objective functions. MATLAB was employed to explore a multiobjective automatic optimization procedure for the optimal design of outrigger numbers and locations under wind load. In this research, various schemes for the preliminary stages of design can be obtained using MGA. This allows designers and clients easily to compare the performance of structural systems with different numbers of outriggers in different locations. In addition, design results based on MGA offer many other benefits, such as diversity, flexible options for designers, and active client participation.
Female genital schistosomiasis (FGS) in Ogun State, Nigeria: a pilot survey on genital symptoms and clinical findings
Authors: EKPO U. F. , ODEYEMI O. M. , SAM-WOBO S. O. , ONUNKWOR O. B. , MOGAJI H. O. , OLUWOLE A. S. , ABDUSSALAM H. O. , STOTHARD J. R. 
Published: August 2017

SUMMARY
The Nigerian national control programme (NCP) for schistosomiasis does not have a specific action plan for female genital schistosomiasis (FGS), mainly due to gaps in epidemiological and clinical surveillance. To address this, we conducted a pilot investigation for FGS in girls (&gt;5 and ≤15 years) and adult women (≥16 years) in four rural communities near Abeokuta, Ogun State. Urine samples were collected from 317 participants [children (n = 187), adults (n = 130)] and examined for ova of S
chistosoma haematobium by microscopy. A total of 149 participants (47·0%) had egg-patent urogenital schistosomiasis [children (64·7%), adults (21·6%)], reported blood in urine was common (44·5%) as well as sign-post symptoms of FGS. To verify FGS directly, 20 adult women each underwent a gynaecological investigation by colposcopy with observed lesions classified according to the WHO FGS pocket atlas. Fourteen (70·0%) women presented with FGS as grainy-sandy patches (n = 10), homogenous yellow sandy patches (n = 6), nabothian cysts and rubbery papules (n = 1). Our study confirms FGS in Ogun State and calls for further appraisals of this disease in other areas where urogenital schistosomiasis is endemic. The Nigerian NCP should be encouraged to develop an appropriate response to FGS not only to detect it, but also to prevent it.
In vitro antileishmanial activity and iron superoxide dismutase inhibition of arylamine Mannich base derivatives
Authors: MARTIN-MONTES ALVARO , SANTIVAÑEZ-VELIZ MERY , MORENO-VIGURI ELSA , MARTÍN-ESCOLANO RUBÉN , JIMÉNEZ-MONTES CARMEN , LOPEZ-GONZALEZ CATALINA , MARÍN CLOTILDE , SANMARTÍN CARMEN , GUTIÉRREZ SÁNCHEZ RAMÓN , SÁNCHEZ-MORENO MANUEL , PÉREZ-SILANES SILVIA 
Published: August 2017

SUMMARYLeishmaniasis is one of the world's most neglected diseases, and it has a worldwide prevalence of 12 million. There are no effective human vaccines for its prevention, and treatment is hampered by outdated drugs. Therefore, research aiming at the development of new therapeutic tools to fight leishmaniasis remains a crucial goal today. With this purpose in mind, we present 20 arylaminoketone derivatives with a very interesting in vitro and in vivo efficacy against Trypanosoma cruzi that have now been studied against promastigote and amastigote forms of Leishmania infantum, Leishmania donovani and Leishmania braziliensis strains. Six out of the 20 Mannich base-type derivatives showed Selectivity Index between 39 and 2337 times higher in the amastigote form than the reference drug glucantime. These six derivatives affected the parasite infectivity rates; the result was lower parasite infectivity rates than glucantime tested at an IC25 dose. In addition, these derivatives were substantially more active against the three Leishmania species tested than glucantime. The mechanism of action of these compounds has been studied, showing a greater alteration in glucose catabolism and leading to greater levels of iron superoxide dismutase inhibition. These molecules could be potential candidates for leishmaniasis chemotherapy.
Domain-Specific Cognitive Recovery after First-Ever Stroke: A 2-Year Follow-Up
Authors: Turunen Katri E.A. , Laari Siiri P.K. , Kauranen Tatu V. , Uimonen Jenni , Mustanoja Satu , Tatlisumak Turgut , Poutiainen Erja 
Published: August 2017

AbstractObjectives: The aim of this work was to study the change in different cognitive domains after stroke during a 2-year follow-up. Method: We evaluated both neuropsychologically and neurologically a consecutive cohort of working-age patients with a first-ever stroke at baseline (within the first weeks), 6 months, and 2 years after stroke-onset. A total of 153 patients participated in all examinations and were compared to 50 healthy controls. Results: Forty-nine percent of the patients were cognitively impaired at baseline, 41% at 6 months, and 39% at 2-year follow-up. We analyzed seven cognitive domains (impairment rates at baseline and 2-year follow-up): psychomotor speed (34%; 23%), executive functions (27%; 17%), visual memory (21%; 4%), visuospatial function (20%; 14%), verbal memory (18%; 12%), basic language processing (baseline 11%; 6 months 5%), and reasoning (2 years 14%). The patients who were cognitively impaired at baseline improved more within 6 months, than either the controls or cognitively intact patients in all cognitive domains (all p<.05). Later on, between 6 months and 2 years, the domain-specific change scores did not differ between patients who were cognitively intact and impaired at 6 months. Also, the cognitive status (intact or impaired) remained the same in 90% of patients between 6-month and 2-year follow-ups. At 2 years, half of the patients, who were categorized cognitively impaired, were rated as well-recovered according to neurological evaluation. Conclusions: Most of the cognitive improvement took place within 6 months. Long-lasting cognitive impairment was common even after good neurological recovery. An early neuropsychological examination is essential in evaluating cognitive dysfunction and need for rehabilitation. (JINS, 2018, 24, 117–127)
Affluence and emission tradeoffs: evidence from Indonesian households' carbon footprint
Authors: Irfany Mohammad Iqbal , Klasen Stephan 
Published: August 2017

AbstractThis study estimates Indonesian households’ carbon emissions that are attributed to their expenditures in 2005 and 2009 to analyze the pattern, distribution and drivers of their carbon footprint. Employing an input-output-emission-expenditure framework, the authors find a significant difference in household carbon emissions between different affluence levels, regions and educational levels. They also find that, while many household characteristics influence emissions, total expenditure is by far the most important determinant of household emissions, both across households and over time. Consequently, emissions inequality is very similar to expenditure inequality across households. The decomposition analysis confirms that changes in emissions are predominantly due to rising expenditures between the two periods, while expenditure elasticities analysis suggests that the rise in household emissions is mainly caused by the overall rise in total household expenditure, and not by shifting consumption shares among consumption categories. The paper discusses policy options for Indonesia to reduce this very strong expenditure–emissions link.
Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy
Authors: Genabai Naresh K. , Kannan Annapoorna , Ahmad Saif , Jiang Xiaoting , Bhatia Kanchan , Gangwani Laxman 
Published: August 2017

AbstractSpinal muscular atrophy (SMA) is caused by the low levels of survival motor neuron (SMN) protein and is characterized by motor neuron degeneration and muscle atrophy. Respiratory failure causes death in SMA but the underlying molecular mechanism is unknown. The zinc finger protein ZPR1 interacts with SMN. ZPR1 is down regulated in SMA patients. We report that ZPR1 functions downstream of SMN to regulate HoxA5 levels in phrenic motor neurons that control respiration. Spatiotemporal inactivation of Zpr1 gene in motor neurons down-regulates HoxA5 and causes defects in the function of phrenic motor neurons that results in respiratory failure and perinatal lethality in mice. Modulation in ZPR1 levels directly correlates and influences levels of HoxA5 transcription. In SMA mice, SMN-deficiency causes down-regulation of ZPR1 and HoxA5 that result in degeneration of phrenic motor neurons. Identification of ZPR1 and HoxA5 as potential targets provides a paradigm for developing strategies to treat respiratory distress in SMA.
Two-color heterodyne laser interferometry for long-distance stage measurement with correction of uncertainties in measured optical distances
Authors: Liu Zhaowu , Li Wenhao , Bayanheshig  , Li Xiaotian , Jiang Shan , Song Ying , Lv Qiang 
Published: August 2017

AbstractWe designed a new system that eliminates deviations by correcting uncertainty in optical distance measurements in the laser two-color heterodyne interferometer. In simulations, eliminating the uncertainty from the atmosphere, the deviation in the uncertainty of the optical distance was 50 times greater with the two-color method than with the one-color method. Adding a correction arm reduces the deviation caused by the uncertainties in measured optical distances. The uncertainty in the measured path length is reduced to 20 nm over a path length of 1500 mm, giving a relative uncertainty of 1.34 × 10
−8.
Dipeptidyl peptidase-4 inhibitors and cancer risk in patients with type 2 diabetes: a meta-analysis of randomized clinical trials
Authors: Zhao Ming , Chen Jiayi , Yuan Yanyan , Zou Zuquan , Lai Xiaolong , Rahmani Daud M , Wang Fuyan , Xi Yang , Huang Qin , Bu Shizhong 
Published: August 2017

AbstractSome recent studies have suggested that the use of dipeptidyl peptidase-4 inhibitors (DPP4i) is associated with cancer development. However, some other studies suggest no such association. The aim of the present study was to evaluate the effect of DPP4i on the risk of developing cancers. The electronic databases PubMed, Medline, EMBASE, Web of Science and Cochrane Library and the clinical trial registry were searched for published and unpublished randomized clinical trials on humans. Eligible studies were RCTs conducted in patients with type 2 diabetes mellitus, comparing DPP4i with a placebo or other active drugs. A total of 72 trials with 35,768 and 33,319 patients enrolled for DPP4i and the comparison drugs, respectively. Overall, no significant associations were detected between the use of DPP4i and cancer development, in comparison with the use of other active drugs or placebo. The results were consistent across pre-defined subgroups stratified by type of DPP4i, type of cancer, drug for comparison, trial duration, or baseline characteristics. The results of this meta-analysis suggest that patients with type 2 diabetes treated with DPP4i do not have a higher risk of developing cancers than patients treated with a placebo or other drugs.
2,4,6-Trinitrotoluene Induces Apoptosis via ROS-Regulated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in HepG2 and Hep3B Cells
Authors: Liao Hung-Yu , Kao Chih-Ming , Yao Chao-Ling , Chiu Po-Wei , Yao Chun-Chen , Chen Ssu-Ching 
Published: August 2017

Abstract2,4,6-trinitrotoluene (TNT) has been reported to cause numerous adverse effects. However, the detailed molecular mechanisms underlying TNT-induced liver toxicity need to be elucidated. In this study, we used HepG2 (p53wt) and Hep3B (p53null) cell lines to investigate the cytotoxic effects of TNT. At first, we found that TNT significantly decreased cell viability and induced DNA damage. Thereafter, through transcriptomic analysis, we observed that the diverse biological functions affected included mitochondrial dysfunction and endoplasmic reticulum (ER) stress. Mitochondrial dysfunction was evidenced by the loss of mitochondrial membrane potential, increased expression of cleaved-caspase-9&-3 and increased caspase-3/7 activity, indicating that apoptosis had occurred. In addition, the expressions of some ER stress-related proteins had increased. Next, we investigated the role of reactive oxygen species (ROS) in TNT-induced cellular toxicity. The levels of DNA damage, mitochondrial dysfunction, ER stress and apoptosis were alleviated when the cells were pretreated with N-acetyl-cysteine (NAC). These results indicated that TNT caused the ROS dependent apoptosis via ER stress and mitochondrial dysfunction. Finally, the cells transfected with CHOP siRNA significantly reversed the TNT-induced apoptosis, which indicated that ER stress led to apoptosis. Overall, we examined TNT-induced apoptosis via ROS dependent mitochondrial dysfunction and ER stress in HepG2 and Hep3B cells.
Delimiting species of Protaphorura (Collembola: Onychiuridae): integrative evidence based on morphology, DNA sequences and geography
Authors: Sun Xin , Zhang Feng , Ding Yinhuan , Davies Thomas W. , Li Yu , Wu Donghui 
Published: August 2017

AbstractSpecies delimitation remains a significant challenge when the diagnostic morphological characters are limited. Integrative taxonomy was applied to the genusProtaphorura(Collembola: Onychiuridae), which is one of most difficult soil animals to distinguish taxonomically. Three delimitation approaches (morphology, molecular markers and geography) were applied providing rigorous species validation criteria with an acceptably low error rate. Multiple molecular approaches, including distance- and evolutionary model-based methods, were used to determine species boundaries based on 144 standard barcode sequences. Twenty-two molecular putative species were consistently recovered across molecular and geographical analyses. Geographic criteria were was proved to be an efficient delimitation method for onychiurids. Further morphological examination, based on the combination of the number of pseudocelli, parapseudocelli and ventral mesothoracic chaetae, confirmed 18 taxa of 22 molecular units, with six of them described as new species. These characters were found to be of high taxonomical value. This study highlights the potential benefits of integrative taxonomy, particularly simultaneous use of molecular/geographical tools, as a powerful way of ascertaining the true diversity of the Onychiuridae. Our study also highlights that discovering new morphological characters remains central to achieving a full understanding of collembolan taxonomy.