bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lung transplant recipients on long‐term extracorporeal photopheresis
Authors: Isenring Bruno , Robinson Cécile , Buergi Urs , Schuurmans Macé M. , Kohler Malcolm , Huber Lars C. , Benden Christian 
Published: June 2017

AbstractExtracorporeal photophoresis (ECP) is an increasingly used therapy to address chronic lung allograft dysfunction (CLAD) following lung transplantation. In 2008, we reported the first single‐center experience showing that ECP not only reduces lung function decline in patients with bronchiolitis obliterans syndrome (BOS) but results in stabilization of patients with recurrent acute cellular rejection (ACR). In this study, the original cohort was followed up further 5 years. In addition, patients with CLAD were retrospectively classified according to recently published phenotypes. The current cohort included 21 of the original 24 patients, of which nine were initially treated for CLAD, 12 were initially treated for recurrent ACR. Our results show that survival of patients treated with ECP for CLAD was inferior to patients treated for recurrent ACR (66% vs. 82% survival rate). Long‐term survivors in the CLAD subgroup were mostly classified as BOS 1 at time of ECP initiation. These long‐term data show that patients started on ECP at early BOS stages have better long‐term outcome. The subgroup of ECP patients with recurrent ACR has an overall superior survival. To assist prediction of therapy response, we agree with other authors that patients with CLAD should be aimed to be phenotyped and evaluated for an early treatment with ECP.
Implementing a new curriculum for computer‐assisted restorations in prosthetic dentistry
Authors: Schweyen R. , Beuer F. , Bochskanl M. , Hey J. 
Published: June 2017

AbstractIntroductionComputer‐aided design/computer‐aided manufacturing (CAD/CAM) of fixed prosthetic restorations has gained popularity in the last decade. However, this field of dentistry has not been integrated in the dental curriculum at most universities.Material and methodsAccording to the method of Kern, a curriculum was designed and established on a voluntary basis in the prosthetic education of a German dental school. The success of the implementation was measured by evaluation carried out by the participants on a visual analogue scale. Furthermore, the clinical performance of the fabricated restorations was evaluated.ResultsNinety‐four percent of all students participated in the CAD/CAM curriculum indicating considerable interest. Nearly half of all students used the acquired knowledge to design crowns for their patients. All restorations fabricated by participants of the new CAD/CAM programme showed good clinical performance.DiscussionBy phasing‐in the CAD/CAM training programme, independent CAD/CAM‐based fabrication of all‐ceramic crowns increased student's self‐confidence in tooth preparation. A tendency was found that students using CAD/CAM technology prepared more teeth than their fellow students who did not use CAD/CAM technology. Further studies are required to investigate the influence of independent CAD/CAM‐based single‐crown fabrication on the quality of the preparation.
Oropharyngeal botryomycosis in a geriatric mare
Authors: Merchan A. , Jose‐Cunilleras E. , Prades M. , Ribera T. , Viu J. , Rodríguez‐Pozo M. L. , Ramis A. J. 
Published: June 2017

SummaryBotryomycosis is an uncommon chronic bacterial infection that can have cutaneous and visceral involvement. This report describes an 18‐year‐old mixed‐breed mare presented with dysphagia, dyspnoea and an upper respiratory noise that developed secondary to oropharyngeal botryomycosis. Histological examination of the mass showed a granulomatous formation with Splendore–Hoeppli phenomenon surrounding Gram‐positive bacteria. This report describes the clinical signs, approach and management of an oropharyngealStaphylococcus aureusgranuloma in a geriatric mare.
Asymmetric Information in Simple Bargaining Games: An Experimental Study
Authors: Klempt Charlotte , Pull Kerstin , Stadler Manfred 
Published: June 2017

Abstract
Bilateral bargaining situations are often characterized by informational asymmetries concerning the size of what is at stake: in some cases, the proposer is better informed, in others, it is the responder. We analyze the effects of both types of asymmetric information on proposer behavior in two different situations which allow for a variation of responder veto power: the ultimatum and the dictator game. We find that the extent to which proposers demand less in the ultimatum as compared to the dictator game is (marginally) smaller when the proposer is in the superior information position. Further we find informed proposers to exploit their informational advantage by offering an amount that does not reveal the true size of the pie, with proposers in the ultimatum game exhibiting this behavioral pattern to a larger extent than those in the dictator game. Uninformed proposers risk imposed rejection when they ask for more than potentially is at stake, and ask for a risk premium in dictator games. We concentrate on proposers, but also explore responder behavior: We find uninformed responders to enable proposers’ hiding behavior, and we find proposer intentionality not to play an important role for informed responders when they decide whether to accept or reject an offer by an (uninformed) proposer.
Recognition of Chronic Migraine by Medicine Trainees: A Cross‐Sectional Survey
Authors: Yadav Priyanka , Bradley Alec L. , Smith Jonathan H. 
Published: June 2017

ObjectiveChronic migraine is a diagnosis that can be abstracted through the clinical history, although some providers may struggle in properly applying diagnostic criteria. We aimed to learn how well medicine trainees would be able to recognize the diagnostic criteria for chronic migraine and apply that medical knowledge to case vignettes illustrating different symptom interpretation strategies of the identical information.MethodsAn electronic, anonymous and multiple‐choice response questionairre assessing selected trainee characteristics, headache case vignettes, and chronic migraine diagnostic criteria was distributed to all regional medicine program directors and coordinators in Kentucky and surrounding states. Program directors and coordinators could then individually decide whether or not they would forward to their trainees. The primary outcome measure was the frequency of chronic migraine recognition as a function of history style (ie, lumping versus splitting). Secondary outcome measures included recognition of chronic migraine diagnosis as a function of program affiliation (academic versus community), training year, gender, and recognition of ICHD‐3 beta chronic migraine diagnostic criteria. Nominal variables were described as counts and percentages, and compared using chi‐square tests. Statistical tests were considered to be two‐sided and P ≤ .05 was considered to be statistically significant. Statistical analyses were performed using the JMP 11.0.0 (SAS Institute Inc., Cary, NC, USA).ResultsFifty‐six medicine trainees completed the survey. Episodic migraine and chronic tension‐type headache were correctly recognized by 85.7% and 96.4%, respectively. Chronic migraine was recognized by a greater proportion of trainees when the identical information was presented using a lumped versus split symptom interpretation strategy (24.1% vs 3.6%, chi‐square = 6.5, df =1, P = .01). Accurate recognition of chronic migraine was more likely among trainees in community versus academic/university program (40% vs 14.7%, chi‐square = 4.4, df = 1, P = .03) and among male versus female trainees (33.3% vs 9.5%, chi‐square = 3.9, df = 1, P = .04). Interestingly, accurate recognition of chronic migraine diagnosis was neither related to training year nor correct recognition of the ICHD‐3 beta diagnostic criteria for chronic migraine.ConclusionsDespite accurate individual recognition of episodic migraine and chronic tension‐type headache, participants were poor at recognizing that features of these primary headache disorders can co‐exist to comprise a uniform diagnosis of chronic migraine. Accurate diagnosis of chronic migraine was improved with use of a lumping strategy to the headache history.
A zinc oxide‐modified hydroxyapatite‐based cement facilitated new crystalline‐stoichiometric and amorphous apatite precipitation on dentine
Authors: Toledano M. , Pérez‐Álvarez M. C. , Aguilera F. S. , Osorio E. , Cabello I. , Toledano‐Osorio M. , Osorio R. 
Published: June 2017

AbstractAimTo evaluate the remineralization ability of two endodontic sealer cements.MethodologyMid‐coronal dentine surfaces were subjected to: (i) 37% phosphoric acid (PA) or (ii) 0.5 mol L−1 ethylenediaminetetraacetic acid (EDTA) conditioning prior to the application of two experimental hydroxyapatite‐based cements, containing sodium hydroxide (calcypatite) or zinc oxide oxiapatite respectively. Samples were stored in simulated body fluid for 24 h or 21 days. Remineralization of the dentine surfaces were studied by Raman spectroscopy (mapping with K‐means cluster and hierarchical cluster analysis) was undertaken. Nanoroughness and collagen fibril width measurements were performed with an atomic force microscopy. ANOVA and Student–Newman–Keuls test were performed (α=0.05).ResultsPhosphoric acid+oxiapatite promoted both the highest dentine mineralization (P < 0.05) and crystallographic maturity at the dentine surface. Noncrystalline amorphous‐like apatites were also formed. Dentine treated with PA+calcypatite attained the roughest surface (P < 0.05) with minimal fibril width (P < 0.05). Cross‐linking of collagen only became greater in the group PA+oxiapatite after 21 days. The maximum relative mineral concentration and structure of collagen linked to the amide I and ratio amide III/AGEs was obtained after using PA+calcypatite at 21‐days time‐point (P < 0.05). EDTA produced a lower stoichiometric hydroxyapatite (P < 0.05) with decreased maturity, at the expense of carbonate band widening, although it favoured the nucleation of carbonated calcium phosphate.ConclusionsDentine surfaces treated with PA+oxiapatite attained the highest dentine remineralization with both crystalline‐stoichiometric and amorphous apatites, at 21 days. EDTA conditioning facilitated amorphous‐bulk mineral precipitation. The amorphization was more intense after using oxiapatite and provided an ion‐rich environment favouring in situ dentine remineralization.
A prospective clinical study of regenerative endodontic treatment of traumatized immature teeth with necrotic pulps using bi‐antibiotic paste
Authors: Nazzal H. , Kenny K. , Altimimi A. , Kang J. , Duggal M. S. 
Published: June 2017

AbstractAimTo evaluate the treatment outcomes of a revitalization endodontic technique (RET) for the management of traumatized immature teeth with necrotic pulps in children.MethodologyFifteen healthy children (age range = 7–10 years) with traumatized immature maxillary incisors with necrotic pulps treated with bi‐antibiotic revitalization endodontic technique were prospectively assessed over approximately two years (mean = 22 months). One operator undertook all treatments, clinical reviews and standardized radiographic exposures with radiographic analysis being carried out by two calibrated experienced clinicians. Crown colour change was assessed using an objective published methodology. Wilcoxon signed‐rank test was used to compare root lengths, root dentinal widths and apical foramen widths over time.ResultsInteroperator measurement reliability was consistently strong for all measurements. There was no significant difference in root lengths or root dentinal wall widths following RET. A significant difference in apical foramen widths was observed after 2 years (P = 0.013) with resolution of clinical signs of infection in all cases. Despite omitting minocycline and using Portland cement (nonbismuth containing cement), a noticeable crown colour change (yellower, redder and lighter), as measured by an objective colour measurement system with ΔE = 7.39, was recorded. Most patients, however, were satisfied with the aesthetic outcome.ConclusionTraumatized immature teeth with necrotic pulps treated with revitalization endodontic technique did not demonstrate continuation of root development or dentine formation when assessed by periapical radiographs. However, apical closure and periodontal healing were observed. A measurable change in crown colour (yellower, redder and lighter), with mostly no aesthetic concern to the patients/parents, was also observed.
Examining the importance of laboratory and diagnostic testing when treating and diagnosing onychomycosis
Authors: Ghannoum Mahmoud , Mukherjee Pranab , Isham Nancy , Markinson Bryan , Rosso James Del , Leal Luis 
Published: June 2017

AbstractOnychomycosis is a fungal nail infection caused primarily by dermatophytes. Several other nail disorders, including psoriasis, can simulate onychomycosis. Accurate diagnosis is therefore vital for the ongoing treatment and management of onychomycosis and to avoid misdiagnosis and treatment delay, which can be both lengthy and costly. Often, a combination of histologic and laboratory techniques is used to obtain an accurate diagnosis. The potential diagnostic challenges associated with the differential diagnosis of onychomycosis caused by dermatophytes and the most common techniques used to confirm the diagnosis are discussed.
La peur de l'échec: les enjeux de l'emploi des jeunes en Chine
Authors: SCHUCHER Günter 
Published: June 2017

RésuméLes médias donnent de la situation de la jeunesse chinoise une image contradictoire, faisant état d'un chômage des jeunes limité, mais aussi d'une préoccupation croissante des autorités et de la population en général quant à l'insertion professionnelle de la tranche d'âge. À l'issue d'une analyse approfondie, l'auteur établit que les jeunes Chinois pâtissent moins d'une pénurie que d'une inadéquation de l'emploi, notamment les diplômés du supérieur parmi eux, soit la moitié environ de ceux qui se portent sur le marché du travail chaque année. Ces diplômés se plaignent également de salaires décevants et de possibilités de mobilité sociale moins bonnes qu'auparavant.
L'influence des syndicats et les pratiques de formation en entreprise: perspectives du Québec
Authors: HASSI Abderrahman , FOUCHER Roland 
Published: June 2017

RésuméLes auteurs se fondent sur une enquěte auprès de 301 PME québécoises pour analyser l'influence – déjà attestée – de la présence syndicale sur la formation en entreprise. Ils s'attachent notamment à isoler l'effet des clauses relatives à la formation inscrites dans les conventions collectives et montrent que celles‐ci constituent un cadre normatif pour les pratiques de formation et de promotion de l'apprentissage sur le lieu de travail, contribuant ainsi à renforcer l'influence syndicale. Cependant, l'existence de telles clauses (ou leur absence) n'est pas nécessairement associée à un accès amélioré (ou plus limité) aux activités de formation effectives.
CEO equity incentives and the remediation of material weaknesses in internal control
Authors: Liu Xuejiao , Liu Xiaohong 
Published: June 2017

AbstractThis study examines how CEO equity incentives affect the remediation of material weaknesses (MWs) in internal control disclosed pursuant to the Sarbanes‐Oxley Act (SOX). We find that the sensitivity of CEO equity portfolios to stock price (CEO price sensitivity, or delta) has a positive impact on firm promptness in remedying MWs, whereas the sensitivity of CEO equity portfolios to stock return volatility (CEO volatility sensitivity, or vega) has a negative impact on firm promptness in remedying MWs. In addition, we provide evidence that effective boards of directors mitigate the undesirable, negative effect of CEO volatility sensitivity on remediation of MWs. Our results shed light on the effects of equity compensation structures on internal control quality in the more transparent, post‐SOX environment.
The role of IL‐23 and the IL‐23/TH17 immune axis in the pathogenesis and treatment of psoriasis
Authors: Girolomoni G. , Strohal R. , Puig L. , Bachelez H. , Barker J. , Boehncke W.H. , Prinz J.C. 
Published: June 2017

AbstractPsoriasis is a chronic, immune‐mediated disease affecting more than 100 million people worldwide and up to 2.2% of the UK population. The aetiology of psoriasis is thought to originate from an interplay of genetic, environmental, infectious and lifestyle factors. The manner in which genetic and environmental factors interact to contribute to the molecular disease mechanisms has remained elusive. However, the interleukin 23 (IL‐23)/T‐helper 17 (TH17) immune axis has been identified as a major immune pathway in psoriasis disease pathogenesis. Central to this pathway is the cytokine IL‐23, a heterodimer composed of a p40 subunit also found in IL‐12 and a p19 subunit exclusive to IL‐23. IL‐23 is important for maintaining TH17 responses, and levels of IL‐23 are elevated in psoriatic skin compared with non‐lesional skin. A number of agents that specifically inhibit IL‐23p19 are currently in development for the treatment of moderate‐to‐severe plaque psoriasis, with recent clinical trials demonstrating efficacy with a good safety and tolerability profile. These data support the role of this cytokine in the pathogenesis of psoriasis. A better understanding of the IL‐23/TH17 immune axis is vital and will promote the development of additional targets for psoriasis and other inflammatory diseases that share similar genetic aetiology and pathogenetic pathways.
Dual anti‐inflammatory and anti‐parasitic action of topical ivermectin 1% in papulopustular rosacea
Authors: Schaller M. , Gonser L. , Belge K. , Braunsdorf C. , Nordin R. , Scheu A. , Borelli C. 
Published: June 2017

AbstractBackgroundRecently, therapy of rosacea with inflammatory lesions (papulopustular) has improved substantially with the approval of topical ivermectin 1% cream. It is assumed to have a dual mode of action with anti‐inflammatory capacities and anti‐parasitic effects against Demodex, which however has not yet been demonstrated in vivo.AimTo find scientific rationale for the dual anti‐inflammatory and anti‐parasitic mode of action of topical ivermectin 1% cream in patients with rosacea.MethodsA monocentric pilot study was performed including 20 caucasion patients with moderate to severe rosacea, as assessed by investigator global assessment (IGA score ≥3) and a Demodex density ≥15/cm2. Patients were treated with topical ivermectin 1% cream once daily (Soolantra®) for ≥12 weeks. The density of Demodex mites was assessed with skin surface biopsies. Expression of inflammatory and immune markers was evaluated with RT‐PCR and by immunofluorescence staining.ResultsThe mean density of mites was significantly decreased at week 6 and week 12 (P < 0.001). The gene expression levels of IL‐8, LL‐37, HBD3, TLR4 and TNF‐α were downregulated at both time points. Reductions in gene expression were significant for LL‐37, HBD3 and TNF‐α at both follow‐up time points and at week 12 for TLR4 (all P < 0.05). Reduced LL‐37 expression (P < 0.05) and IL‐8 expression were confirmed on the protein level by immunofluorescence staining. All patients improved clinically, and 16 of 20 patients reached therapeutic success defined as IGA score ≤1.ConclusionTopical ivermectin 1% cream acts by a dual, anti‐inflammatory and anti‐parasitic mode of action against rosacea by killing Demodex spp. in vivo, in addition to significantly improving clinical signs and symptoms in the skin.
Explicit dynamics simulation of Pecan fruit deformation under compressive loading—Part‐1: Determination of modulus of elasticity
Authors: Celik H. Kursat 
Published: June 2017

AbstractThis study, which is divided into two parts, introduces an explicit dynamics simulation procedure for Pecan fruit (Carya illinoinensis) deformation under compressive loading. An original application algorithm based on experimental and theoretical methods has been described in the study. The major aim of this Part 1 is to determine the modulus of elasticity through various calculation approaches for Pecan fruit. In addition to this, some engineering properties of the Pecan fruit components were determined to define them as simulation input parameters in an explicit dynamics deformation simulation which is detailed in the second part of the study. The original geometry of the Pecan fruit and its components were digitized using reverse engineering technology (three‐dimensional [3D] laser scanning). Force–deformation data, which can describe the physical deformation characteristics of the Pecan fruit components, was collected through experimental compression tests. Initial crack points for the Pecan shell (kernel‐in‐shell) in these tests were measured as 335.62, 239.42, and 165.03 N for longitudinal, transverse, and suture orientations, respectively. Hooke's, Hertz's, and Boussinesq's theories and finite element method simulation based linear prediction approach based modulus of elasticity calculations were realized. Results from these calculations revealed that loading orientation is an important factor and there were differences between the results of calculation theories (15.2% on average).Practical applicationsThe simulation approach and application algorithm introduced in this two‐part study is a scientific novelty because the explicit dynamics simulation approach for Pecan fruit deformation has not previously been reported in the literature. This first part focuses on realistic description (digitizing) of the fruit geometry through a reverse engineering approach and determination of modulus of elasticity (by considering various theories) and some engineering properties of the Pecan fruit components (experimentally). These investigations have important roles in this study so that realistic material models of the fruit components can be described in the simulation study which is presented and detailed in the second part of the study. In this part, it has been experienced that loading orientation is an effective factor for fruit deformation behavior and different theories may provide different results during calculation of the specific mechanical properties. These important findings have been presented in a form which may be used as input parameters in design studies of shelled agricultural product processing machinery systems used in the related industry.