bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Implant Connection Type and Depth on the Seating Accuracy of Hand‐Tightened Abutments
Authors: Siadat Hakimeh , Belbasi Simin , Alikhasi Marzieh , Nazari Vahideh , Beyabanaki Elaheh 
Published: December 2017

AbstractPurposeImproper seating of abutment on the implant is a common problem. This study investigated the effect of the type of implant/abutment interface on the complete seating of the abutments on the head of implants placed at different gingival depths.Materials and MethodsThree implant systems with three different connections including straight external hexagon, butt‐joint internal tri‐lobed, and conical internal hexagon were used. Two gingival thicknesses (2 and 7 mm) were created using pink baseplate wax around the straight abutments seated on the implants. After placing the implants in acrylic blocks, the wax was replaced with the gingival mask material to simulate the gingival drape around the implant heads. Afterwards, 15 prosthodontists were asked to hand‐tighten the straight abutments in the corresponding implant bodies relying only on their tactile sense. At the final stage, the gingival mask was removed, and the seating quality of the abutments on implant bodies was assessed visually. The effect of implant connection and depth on abutment seating accuracy was analyzed using Kruskal‐Wallis and multiple‐comparison tests.ResultsNo significant difference was found regarding the effect of either depth or connection design on the accuracy of the abutment seating (p > 0.05); however, pairwise comparison of the combined effect of the depth and connection design was significant (p = 0.009). Accuracy of abutment seating on the Nobel Active implants at both 2 and 7 mm depths were significantly better than Replace system with 7 mm depth (p = 0.027). The same results were obtained in comparison between Nobel Active system at both 2 and 7 mm depths with Branemark system with 7 mm depth (p = 0.006).ConclusionAn increase in implant placement depth meant a decrease in accuracy of the abutment seating. The internal conical connection design showed the best result in abutment positioning in deep implants as compared with external and internal butt‐joint connection designs.
Neuromuscular training reduces lower limb injuries in elite female basketball players. A cluster randomized controlled trial
Authors: Bonato M. , Benis R. , La Torre A. 
Published: December 2017

The study was a two‐armed, parallel group, cluster randomized controlled trial in which 15 teams (160 players) were assigned to either an experimental group (EG, 8 teams n = 86), which warmed‐up with bodyweight neuromuscular exercises, or a control group (CG, 7 teams, n = 74) that performed standard tactical‐technical exercises before training. All injuries during the 2015‐2016 regular season were counted. Epidemiologic incidence proportion and incidence rate were also calculated. Countermovement jump (CMJ) and composite Y‐Excursion Balance test (YBT) were used to assess lower limb strength and postural control. A total of 111 injuries were recorded. Chi‐square test detected statistically significant differences between EG and CG (32 vs 79, P = .006). Significant differences in the injuries sustained in the EG (21 vs 11, P = .024) and CG (52 vs 27, P = .0001) during training and matches, respectively, were observed. Significant differences in post‐intervention injuries were observed between in EG and CG during training (21 vs 52, P < .0001) and matches (11 vs 27, P = .006). Significant differences in epidemiologic incidence (0.37 vs 1.07, P = .023) and incidence rate (1.66 vs 4.69, P = .012) between the EG and the CG were found. Significant improvement in CMJ (+9.4%, P < .0001; d = 1.2) and composite YBT (right: +4.4%, P = .001, d = 1.0; left: +3.0%, P = .003; d = 0.8) for the EG was noted. Significant differences in post‐intervention CMJ (+5.9%, P = .004) and composite YBT scores (right, +3.7%, P = .012; left, +2.3%, P = .007) between the EG and the CG were observed. Including bodyweight neuromuscular training into warm‐up routines reduced the incidence of serious lower limb injuries in elite female basketball players.
Zoonotic origin and transmission of Middle East respiratory syndrome coronavirus in the UAE
Authors: Paden C. R. , Yusof M. F. B. M. , Al Hammadi Z. M. , Queen K. , Tao Y. , Eltahir Y. M. , Elsayed E. A. , Marzoug B. A. , Bensalah O. K. A. , Khalafalla A. I. , Al Mulla M. , Khudhair A. , Elkheir K. A. , Issa Z. B. , Pradeep K. , Elsaleh F. N. , Imambaccus H. , Sasse J. , Weber S. , Shi M. , Zhang J. , Li Y. , Pham H. , Kim L. , Hall A. J. , Gerber S. I. , Al Hosani F. I. , Tong S. , Al Muhairi S. S. M. 
Published: December 2017

SummarySince the emergence of Middle East respiratory syndrome coronavirus (MERS‐CoV) in 2012, there have been a number of clusters of human‐to‐human transmission. These cases of human‐to‐human transmission involve close contact and have occurred primarily in healthcare settings, and they are suspected to result from repeated zoonotic introductions. In this study, we sequenced whole MERS‐CoV genomes directly from respiratory samples collected from 23 confirmed MERS cases in the United Arab Emirates (UAE). These samples included cases from three nosocomial and three household clusters. The sequences were analysed for changes and relatedness with regard to the collected epidemiological data and other available MERS‐CoV genomic data. Sequence analysis supports the epidemiological data within the clusters, and further, suggests that these clusters emerged independently. To understand how and when these clusters emerged, respiratory samples were taken from dromedary camels, a known host of MERS‐CoV, in the same geographic regions as the human clusters. Middle East respiratory syndrome coronavirus genomes from six virus‐positive animals were sequenced, and these genomes were nearly identical to those found in human patients from corresponding regions. These data demonstrate a genetic link for each of these clusters to a camel and support the hypothesis that human MERS‐CoV diversity results from multiple zoonotic introductions.
Impact of Cell Surface Molecules on Conjugative Transfer of the Integrative and Conjugative Element ICE
St3
of Streptococcus thermophilus
Authors: Dahmane Narimane , Robert Emilie , Deschamps Julien , Meylheuc Thierry , Delorme Christine , Briandet Romain , Leblond-Bourget Nathalie , Guédon Eric , Payot Sophie 
Published: December 2017

ABSTRACT

Integrative conjugative elements (ICEs) are chromosomal elements that are widely distributed in bacterial genomes, hence contributing to genome plasticity, adaptation, and evolution of bacteria. Conjugation requires a contact between both the donor and the recipient cells and thus likely depends on the composition of the cell surface envelope. In this work, we investigated the impact of different cell surface molecules, including cell surface proteins, wall teichoic acids, lipoteichoic acids, and exopolysaccharides, on the transfer and acquisition of ICE
St3
from
Streptococcus thermophilus
. The transfer of ICE
St3
from wild-type (WT) donor cells to mutated recipient cells increased 5- to 400-fold when recipient cells were affected in lipoproteins, teichoic acids, or exopolysaccharides compared to when the recipient cells were WT. These mutants displayed an increased biofilm-forming ability compared to the WT, suggesting better cell interactions that could contribute to the increase of ICE
St3
acquisition. Microscopic observations of
S. thermophilus
cell surface mutants showed different phenotypes (aggregation in particular) that can also have an impact on conjugation. In contrast, the same mutations did not have the same impact when the donor cells, instead of recipient cells, were mutated. In that case, the transfer frequency of ICE
St3
decreased compared to that with the WT. The same observation was made when both donor and recipient cells were mutated. The dominant effect of mutations in donor cells suggests that modifications of the cell envelope could impair the establishment or activity of the conjugation machinery required for DNA transport.

IMPORTANCE
ICEs contribute to horizontal gene transfer of adaptive traits (for example, virulence, antibiotic resistance, or biofilm formation) and play a considerable role in bacterial genome evolution, thus underlining the need of a better understanding of their conjugative mechanism of transfer. While most studies focus on the different functions encoded by ICEs, little is known about the effect of host factors on their conjugative transfer. Using ICE
St3
of
S. thermophilus
as a model, we demonstrated the impact of lipoproteins, teichoic acids, and exopolysaccharides on ICE transfer and acquisition. This opens up new avenues to control gene transfer mediated by ICEs.
Antivascular endothelial growth factor agents pretreatment before vitrectomy for complicated proliferative diabetic retinopathy: a meta-analysis of randomised controlled trials
Authors: Zhao Xin-yu , Xia Song , Chen You-xin 
Published: December 2017

Background/aimsTo evaluate the efficacy of antivascular endothelial growth factor (anti-VEGF) agents pretreatment before vitrectomy for patients with complicated proliferative diabetic retinopathy (PDR).MethodsThe PubMed, Embase and the Cochrane Central Register of Controlled Trials were searched up to June 2017 to identify related studies. The Peferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed. The StataSE V.12.0 software was used to analyse the relevant data. The weighted mean difference, relative risk and their 95% CIs were used to assess the strength of the association.Results14 randomised controlled trials involving 613 patients were assessed, the anti-VEGF pretreatment group included 289 patients and the control group included 324 patients. Our analysis indicated that anti-VEGF pretreatment before vitrectomy for complicated PDR could facilitate much easier surgery regarding less intraoperative bleeding, less endodiathermy, shorter duration of surgery, less iatrogenic retinal breaks, less frequency of using silicone oil and relaxing retinotomy (P<0.05). Additionally, anti-VEGF pretreatment could also achieve better postoperative best-corrected visual acuity, less early recurrent vitreous haemorrhage (VH) and quicker absorption of recurrent VH (P<0.05). However, the incidence of late recurrent VH, recurrent retinal detachment or related secondary surgery could not be reduced (P>0.05).ConclusionThe pretreatment of anti-VEGF agents before vitrectomy for patients with complicated PDR might facilitate much easier surgery and better visual rehabilitation, reduce the rate of early recurrent VH and accelerate its absorption. Moreover, future better-designed studies with larger sample sizes are required to further evaluate the efficacy of different anti-VEGF agents and reach a firmer conclusion.
Risk factors for feelings of sadness and suicide attempts among cancer survivors in South Korea: findings from nationwide cross-sectional study (KNHANES IV–VI)
Authors: Choi Jeewoong , Lee Mijo , Ki Myung , Lee Ju-Yeong , Song Yeong-Jun , Kim Miram , Lee Sunyoung , Park Soonjoo , Lim Jiseun 
Published: December 2017

IntroductionAs the number of cancer survivors is rapidly increasing with the increased incidence of the disease and improved survival of patients, the prevalence of, and risk factors for, mental health problems and suicidality among cancer survivors should be examined.Methods and analysisUsing data obtained from the Korean National Health and Nutrition Examination Survey (2007–2013), we examined 1285 and 33 772 participants who had been and never been diagnosed with cancer, respectively. We investigated the risks of feelings of sadness and suicide attempts among cancer survivors and general population and examined differences in the risks of cancer survivors among subgroups according to cancer-related characteristics.ResultsThe median age of survivors at the time of the survey and at diagnosis was 63 and 54 years, respectively. After adjusting for sex, level of education, household income, occupation, marital status, cancer type, current status of treatment, age at diagnosis and years since diagnosis, the risk of suicide attempts was significantly higher in participants diagnosed with cancer before 45 years of age compared with those diagnosed at 45–64 years (adjusted OR=3.81, 95% CI 1.07 to 13.60, P=0.039), and the higher risk of suicide attempts with borderline significance was found in those for whom more than 10 years had passed since diagnosis compared with those for whom the diagnosis was made only 2–10 years ago (adjusted OR=3.38, 95% CI 0.98 to 11.70, P=0.055). However, feelings of sadness were not significantly associated with any cancer-related characteristic.ConclusionOur results reveal an increased risk of suicide attempts among cancer survivors diagnosed early in life and in those for whom more than 10 years has passed since the diagnosis, suggesting the need for intensive monitoring and support for mental health problems and suicidal risks in this population.
Sex differences in non-communicable disease prevalence in China: a cross-sectional analysis of the China Health and Retirement Longitudinal Study in 2011
Authors: Liu Yan , Liu Guofeng , Wu Hongjiang , Jian Weiyan , Wild Sarah H , Gasevic Danijela 
Published: December 2017

ObjectivesTo describe the sex differences in the prevalence of non-communicable diseases (NCDs) in adults aged 45 years or older in China.DesignCross-sectional study.SettingNationally representative sample of the Chinese population 2011.Participants8401 men and 8928 women over 45 years of age who participated in the first wave of the China Health and Retirement Longitudinal Study (CHARLS).Outcome measuresSelf-reported data on overall health and diagnosis of hypertension, dyslipidaemia, diabetes, heart disease, stroke, chronic lung disease, cancer or arthritis. Sex differences in NCDs were described using logistic regression to generate odds ratios (OR) with adjustment for sociodemographic factors and health-related behaviours. All analyses were stratified by age group for 45–64-year-old and ≥65-year-old participants.ResultsIn both age groups, men reported better overall health than women. The crude prevalence of heart disease, cancer and arthritis was higher while that of stroke and chronic lung disease was lower in women than in men. After adjustment, ORs (95% CI) for the 45–64 and ≥65 year age groups were 0.70 (0.58 to 0.84) and 0.66 (0.54 to 0.80), respectively, for arthritis for men compared with women. In contrast, ORs were 1.66 (1.09 to 2.52) and 2.12 (1.36 to 3.30) for stroke and 1.51 (1.21 to 1.89) and 1.43 (1.09 to 1.88) for chronic lung disease for men compared with women. ORs for heart disease (0.65 (0.52 to 0.80)) were lower in men than in women only in the 45–64 year age group.ConclusionsOdds of arthritis were lower while those of stroke and chronic lung disease were higher in men than in women in both age groups. However, odds of heart disease were lower in men than in women, but only in the group of individuals aged 45–64 years.
Association of sleep duration and quality with blood lipids: a systematic review and meta-analysis of prospective studies
Authors: Kruisbrink Marlot , Robertson Wendy , Ji Chen , Miller Michelle A , Geleijnse Johanna M , Cappuccio Francesco P 
Published: December 2017

ObjectivesTo assess the longitudinal evidence of the relationships between sleep disturbances (of quantity and quality) and dyslipidaemia in the general population and to quantify such relationships.SettingSystematic review and meta-analysis following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.MethodsWe performed a systematic search of PubMed and Embase (up to 9 September 2017), complemented with manual searches, of prospective population studies describing the association between sleep duration and quality and the incidence of dyslipidaemias. Relative risks (95% CIs) were extracted and pooled using a random effects model. Subgroup analyses by lipid type were performed. Heterogeneity and publication bias were also assessed. Quality was assessed with Downs and Black score.ParticipantsStudies were included if they were prospective, had measured sleep quantity and/or quality at baseline and either incident cases of dyslipidaemia or changes in blood lipid fractions assessed prospectively.Primary outcome measuresIncidence of dyslipidaemia and changes in lipid fractions. Dyslipidaemia was defined as a high total cholesterol, triglycerides, low-density lipoprotein cholesterol or low high-density lipoprotein cholesterol compared with the reference group.ResultsThirteen studies were identified (eight using sleep duration, four sleep quality and one both). There was heterogeneity in the sleep quality aspects and types of lipids assessed. Classification of sleep duration (per hour/groups) also varied widely. In the pooled analysis of sleep duration (6 studies, 16 cohort samples; 30 033 participants; follow-up 2.6–10 years), short sleep was associated with a risk of 1.01 (95% CI 0.93 to 1.10) of developing dyslipidaemia, with moderate heterogeneity (I2=56%, P=0.003) and publication bias (P=0.035). Long sleep was associated with a risk of 0.98 (95% CI 0.87 to 1.10) for dyslipidaemia, with heterogeneity (I2=63%, P<0.001) and no significant publication bias (P=0.248).ConclusionThe present analysis was unable to find supportive evidence of a significant relationship between sleep duration and the development of dyslipidaemia. However, heterogeneity and small number of studies limit the interpretation.PROSPERO registration numberCRD42016045242.
Protocol for a randomised pilot multiple centre trial of conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU)
Authors: Jones Gareth A L , Ramnarayan Padmanabhan , Raman Sainath , Inwald David , Grocott Michael P W , Eaton Simon , Ray Samiran , Griksaitis Michael J , Pappachan John , Wiley Daisy , Mouncey Paul R , Wulff Jerome , Harrison David A , Rowan Kathryn M , Peters Mark J 
Published: December 2017

IntroductionOptimal targets for systemic oxygenation in paediatric critical illness are unknown. Observational data indicate that high levels of arterial oxygenation are associated with poor outcomes in resuscitation of the newborn and in adult critical illness. Within paediatric intensive care units (PICUs), staff prevent severe hypoxia wherever possible, but beyond this there is no consensus. Practice varies widely with age, diagnosis, treating doctor and local or national guidelines followed, though peripheral blood oxygen saturations (SpO2) of >95% are often targeted. The overall aim of this pilot study is to determine the feasibility of performing a randomised trial in critically ill children comparing current practice of liberal SpO2targets with a more conservative target.Methods and analysisOxy-PICU is a pragmatic, open, pilot randomised controlled trial in infants and children requiring mechanical ventilation and receiving supplemental oxygen for abnormal gas exchange accepted for emergency admission to one of three participating UK PICUs. The study groups will be either a conservative SpO2target of 88%–92% (inclusive) or a liberal SpO2target of >94%. Infants and children who fulfil all inclusion criteria and none of the exclusion criteria will be randomised 1:1 by a secure web-based system to one of the two groups. Baseline demographics and clinical status will be recorded as well as daily measures of oxygenation and organ support. Discharge outcomes will also be recorded. In addition to observational data, blood and urine samples will be taken to identify biochemical markers of oxidative stress. Outcomes are targeted at assessing study feasibility with a primary outcome of adequate study recruitment (target: 120 participants).Ethics and disseminationThe trial received Health Research Authority approval on 1 June 2017 (16/SC/0617). Study findings will be disseminated in national and international conferences and peer-reviewed journals.Trial registration numberNCT03040570.
Protocol for the ROBUST (Registry Of type B aortic dissection with the Utility of STent graft) study: an ambispective, multicentre, open cohort study
Authors: Rong Dan , Ge Yangyang , Xue Yan , Liu Feng , Lu Kai , Liu Peng , Zhang Lei , Ge Xiaohu , Miu Jianhang , Zhong Linkun , Fan Weidong , Zhang Hongpeng , Jia Xin , Ma Xiaohui , Xiong Jiang , Liu Xiaoping , Guo Wei 
Published: December 2017

IntroductionThoracic endovascular aortic repair (TEVAR) is widely used for type B aortic dissection, although with satisfactory outcome in a limited proportion of patients. To better inform patient prognostication, the Registry Of type B aortic dissection with the Utility of STent graft (ROBUST) study aims to identify imaging-based predictors of post-TEVAR adverse outcomes up to 10-year follow-up.Methods and analysisROBUST is designed as an ambispective, multicentre, open cohort study. All patients undergoing TEVAR from 1 January 2008 to 1 July 2027 at participating centres will be invited to join the study. It is conservatively estimated that over 2000 patients will join the study. Data on demographics, disease history, procedural details, imaging features and follow-up will be collected after discharge. Cox proportional-hazards analysis will be used to identify independent predictors of primary outcomes. Stratification analysis will be performed to identify which subgroup of patients would benefit the most from TEVAR.Ethics and disseminationThe protocol has been approved by the ethics committee of the coordinating centre. Findings will be disseminated in professional peer-reviewed journals to promote understanding of the rehabilitation process.Trial registration numberChiCTR-POC-17011726; Pre-results.
Mystery shopping and coaching as a form of audit and feedback to improve community pharmacy management of non-prescription medicine requests: an intervention study
Authors: Collins Jack Charles , Schneider Carl Richard , Naughtin Clare Louise , Wilson Frances , de Almeida Neto Abilio Cesar , Moles Rebekah Jane 
Published: December 2017

ObjectivesTo determine whether repeated mystery shopping visits with feedback improve pharmacy performance over nine visits and to determine what factors predict an appropriate outcome.DesignProspective, parallel, repeated intervention, repeated measures mystery shopping (pseudopatient) design.SettingThirty-six community pharmacies in metropolitan Sydney, Australia in March–October 2015.ParticipantsSixty-one University of Sydney pharmacy undergraduates acted as mystery shoppers. Students enrolled in their third year of Bachelor of Pharmacy in 2015 were eligible to participate. Any community pharmacy in the Sydney metropolitan region was eligible to take part and was selected through convenience sampling.InterventionRepeated mystery shopping with immediate feedback and coaching.Outcome measuresOutcome for each given scenario (appropriate or not) and questioning scores for each interaction.ResultsFive hundred and twenty-one visits were analysed, of which 54% resulted in an appropriate outcome. Questioning scores and the proportion of interactions resulting in an appropriate outcome significantly improved over time (P<0.001). Involvement of pharmacists, visit number, increased questioning score and the prescribed scenario were predictors of an appropriate outcome (P=0.008, P=0.022, P<0.001 and P<0.001, respectively). Interactions involving a pharmacist had greater scores than those without (P<0.001).ConclusionsRepeated mystery shopping visits with feedback were associated with improved pharmacy performance over time. Future work should focus on the role of non-pharmacist staff and design interventions accordingly.