bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving hospital death certification in Viet Nam: results of a pilot study implementing an adapted WHO hospital death report form in two national hospitals
Authors: Walton Merrilyn , Harrison Reema , Chevalier Anna , Esguerra Esmond , Van Duong Dang , Chinh Nguyen Duc , Giang Huong 
Published: April 2016

BackgroundViet Nam does not have a system for the national collection of death data that meets international requirements for mortality reporting. It is identified as a ‘no-report’ country by the WHO. Verbal autopsy reports are used in the community but exclude deaths in hospitals.MethodsThis project was undertaken in Bach Mai National General Hospital and Viet Duc Surgical and Trauma Hospital in Viet Nam from 1 March 2013 to 31 March 2015. In phase 1, a modified hospital death report form, consistent with the International Statistical Classification of Diseases and Related Health Problems, 10th Revision, was developed. Small group training in use of the report form was delivered to 427 doctors. In phase two, death data were collected, collated and analysed. In phase three, a random sample (7%) of all report forms was checked for accuracy and completeness against medical records.FindingsDuring the 23 months of the study, 3956 deaths were recorded. Across both hospitals, 222 distinct causes of deaths were recorded. Traumatic cerebral oedema was the immediate cause of death (15% of cases, 575/3956 patients), followed by septic shock (13%, 528/3956), brain compression (11%, 416/3956), intracerebral haemorrhage (8%, 336/3956) and pneumonia (5%, 186/3956); 67% (2639/3956) of patients were discharged home to die and 33% (1314/3956) of deaths were due to a road traffic accident, or injury at home or at work.ConclusionsThis study confirms the viability of implementing a death report form system compliant with international standards in hospitals in Viet Nam and provides the foundation for introducing a national death report form scheme. These data are critical to comprehensive knowledge of causes of death in Viet Nam. Death data about patients discharged home to die is presented for the first time, with implications for countries where this is a cultural preference.
Influence of work-related psychosocial factors on the prevalence of chronic pain and quality of life in patients with chronic pain
Authors: Yamada Keiko , Matsudaira Ko , Imano Hironori , Kitamura Akihiko , Iso Hiroyasu 
Published: April 2016

ObjectivesWorking is a common cause of chronic pain for workers. However, most of them need to continue working despite the pain in order to make a living unless they get a sick leave or retirement. We hypothesised that the therapeutic effect of vocational rehabilitation may depend on psychosocial factors related to the workplace. To test this hypothesis, we examined the association of work-related psychosocial factors with the prevalence of chronic pain or health-related quality of life (HRQoL) among workers with chronic pain.MethodsWe examined 1764 workers aged 20–59 years in the pain-associated cross-sectional epidemiological survey in Japan. The outcomes were (1) chronic pain prevalence among all workers and (2) low Euro QoL (EQ-5D <0.76; mean value of the current study) prevalence among workers with chronic pain according to the degree of workplace social support and job satisfaction. Workplace social support and job satisfaction were measured using the Brief Job Stress Questionnaire. Multivariable-adjusted ORs were calculated using a logistic regression model including age, sex, smoking, exercise, sleep time, work hours, body mass index, personal consumption expenditure, intensity of pain and the presence of severe depressive symptoms.ResultsChronic pain prevalence was higher among males reporting job dissatisfaction compared with those reporting job satisfaction. No difference was observed among women. Chronic pain prevalence did not differ between workers of either sex reporting poor workplace social support compared with those reporting sufficient support. Among workers with chronic pain, low HRQoL was more frequent in those reporting job dissatisfaction. Similarly, low HRQoL was more frequent in patients with chronic pain reporting poor social support from supervisors or co-workers compared with patients reporting sufficient support.ConclusionsWork-related psychosocial factors are critical for HRQoL in patients with chronic pain.
What are the barriers to implementation of cardiopulmonary resuscitation training in secondary schools? A qualitative study
Authors: Zinckernagel Line , Malta Hansen Carolina , Rod Morten Hulvej , Folke Fredrik , Torp-Pedersen Christian , Tjørnhøj-Thomsen Tine 
Published: April 2016

ObjectiveCardiopulmonary resuscitation (CPR) training in schools is recommended to increase bystander CPR and thereby survival of out-of-hospital cardiac arrest, but despite mandating legislation, low rates of implementation have been observed in several countries, including Denmark. The purpose of the study was to explore barriers to implementation of CPR training in Danish secondary schools.DesignA qualitative study based on individual interviews and focus groups with school leadership and teachers. Thematic analysis was used to identify regular patterns of meaning both within and across the interviews.Setting8 secondary schools in Denmark. Schools were selected using strategic sampling to reach maximum variation, including schools with/without recent experience in CPR training of students, public/private schools and schools near to and far from hospitals.ParticipantsThe study population comprised 25 participants, 9 school leadership members and 16 teachers.ResultsSchool leadership and teachers considered it important for implementation and sustainability of CPR training that teachers conduct CPR training of students. However, they preferred external instructors to train students, unless teachers acquired the CPR skills which they considered were needed. They considered CPR training to differ substantially from other teaching subjects because it is a matter of life and death, and they therefore believed extraordinary skills were required for conducting the training. This was mainly rooted in their insecurity about their own CPR skills. CPR training kits seemed to lower expectations of skill requirements to conduct CPR training, but only among those who were familiar with such kits.ConclusionsTo facilitate implementation of CPR training in schools, it is necessary to have clear guidelines regarding the required proficiency level to train students in CPR, to provide teachers with these skills, and to underscore that extensive skills are not required to provide CPR. Further, it is important to familiarise teachers with CPR training kits.
Talking about human papillomavirus and cancer: protocol for a patient-centred study to develop scripted consultations
Authors: Hendry Maggie , Pasterfield Di , Adams Richard , Evans Mererid , Fiander Alison , Robling Michael , Campbell Christine , Makin Matthew , Gollins Simon , Hiscock Julia , Nafees Sadia , Bekkers Marie-Jet , Rose Jan , Williams Olwen , Stanley Margaret , Wilkinson Clare 
Published: April 2016

IntroductionPersistent infection with sexually transmitted, high-risk human papillomavirus (HPV) types is the cause of all cervical cancers and some anogenital and oropharyngeal cancers. HPV is an extremely common asymptomatic infection but little known and poorly understood by the public. Patients with HPV-related cancers have new and challenging information needs due to the complex natural history of HPV and the stigma of sexual transmission. They may ask questions that are outside the remit of the traditional cancer consultation, and there is a lack of guidance on how to counsel them. This study aims to fulfil that need by developing and testing cancer site-specific scripted consultations.Methods and analysisA synthesis of findings generated from previous work, a systematic review of information-based interventions for patients with HPV-related cancers, and interviews with cancer clinicians will provide the evidence base underpinning provisional messages. These will be explored in three phases of face-to-face interviews with 75–90 purposively selected patients recruited in cancer clinics to: (1) select and prioritise the most salient messages, (2) phrase the messages appropriately in plain English and, (3) test their acceptability and usefulness. Phases 1 and 2 will draw on card-sorting methods used in website design. In phase three, we will create cancer site-specific versions of the script and test them using cognitive interviewing techniques.Ethics and disseminationThe study has received ethical approval. Findings will be published in a peer-reviewed journal. The final product will be cancer-specific scripted consultations, most likely in the form of a two-sided information sheet with the most important messages to be conveyed in a consultation on one side, and frequently asked questions for later reading on the reverse. However, they will also be appropriate and readily adaptable to web-based uses.
Perceived clinician–patient communication in the emergency department and subsequent post-traumatic stress symptoms in patients evaluated for acute coronary syndrome
Authors: Chang Bernard P , Sumner Jennifer A , Haerizadeh Myrta , Carter Eileen , Edmondson Donald 
Published: April 2016

ObjectivesEvaluation for a potentially life-threatening cardiac event in the emergency department (ED) is a stressful experience that can result in symptoms of post-traumatic stress disorder, which are associated with increased risk of morbidity and mortality in patients. No study has tested whether good clinician–patient communication in the ED is associated with better psychological outcomes in these individuals and whether it can mitigate other risk factors for post-traumatic stress symptoms (PSS) such as perception of life threat and vulnerability in the ED.MethodsData were analysed from 474 participants in the Reactions to Acute Care and Hospitalization (REACH) study, an observational cohort study of ED predictors of medical and psychological outcomes after evaluation for suspected acute coronary syndrome. Participants were recruited from November 2013 to January 2015 at a single-site academic medical centre (New York-Presbyterian-Columbia University Medical Center). Participants reported threat perceptions in the ED and provided information on their perceptions of clinician–patient communication using the Interpersonal Process of Care Survey. PSS were assessed using the Acute Stress Disorder Scale during follow-up.Results474 subjects were enrolled in the study. Median length of follow-up was 3 days after ED presentation, range 0–30 days, 80% within 8 days. Perceptions of good clinician–patient communication in the ED were associated with lower PSS, whereas increased threat perception was associated with higher PSS. A significant interaction between clinician–patient communication and threat perception on PSS suggested that patients with higher threat perception benefited most from good clinician–patient communication.ConclusionOur study found an association between good clinician–patient communication in the ED during evaluation of potentially life-threatening cardiac events and decreased subsequent post-traumatic stress reactions. This association is particularly marked for patients who perceive the greatest degree of life threat and vulnerability during evaluation.
Hiatus hernia in healthy volunteers is associated with intrasphincteric reflux and cardiac mucosal lengthening without traditional reflux
Authors: Robertson Elaine V , Derakhshan Mohammad H , Wirz Angela A , Mitchell David R , Going James J , Kelman Andrew W , Ballantyne Stuart A , McColl Kenneth E L 
Published: April 2016

Background and aimsHiatus hernia (HH) is a key mediator of gastro-oesophageal reflux disease but little is known about its significance in the general population. We studied the structure and function of the gastro-oesophageal junction in healthy volunteers with and without HH.MethodsWe compared 15 volunteers with HH, detected by endoscopy or MRI scan, but without gastro-oesophageal reflux disease with 15 controls matched for age, gender and body weight. Jumbo biopsies were taken across the squamocolumnar junction (SCJ). High-resolution pH metry (12 sensors) and manometry (36 sensors) were performed upright and supine, before and after a meal. The SCJ was marked with an endoscopically placed clip and visualised fluoroscopically.ResultsCardiac mucosa was longer in volunteers with HH (3.5 vs 2.5 mm, p=0.01). There was no excessive acid reflux 5 cm above the upper border of the lower oesophageal sphincter (LOS) in either group but those with HH had short segment reflux 11 mm above the pH transition point after the meal when supine (pH<4 for 5.5% vs 0.3% of time, p=0.01). The SCJ and pH transition point were proximally displaced within the gastro-oesophageal junction in those with HH versus controls (p<0.05). The pH transition point was proximal to the peak LOS pressure point in HH subjects but distal to it in controls after the meal (p<0.05). When supine, the postprandial pH transition point crossed the SCJ in those with HH (p=0.03).ConclusionsHealthy volunteers with HH have increased intrasphincteric reflux and lengthening of cardiac mucosa in the absence of traditional transsphincteric reflux.
Novel Design of Heterogeneous Automation Controller Based on Real-Time Data Distribution Service Middleware to Avoid Obsolescence Challenges
Authors: Sait Sadiq M. , Al-Hashim Ghalib A. 
Published: April 2016

Oil and gas processing facilities utilize various process automation systems with proprietary controllers. As the systems age; older technologies become obsolete resulting in frequent premature capital investments to sustain their operation. This paper presents a new design of automation controller to provide inherent mechanisms for upgrades and/or partial replacement of any obsolete components without obligation for a complete system replacement throughout the expected life cycle of the processing facilities. The input/output racks are physically and logically decoupled from the controller by converting them into distributed autonomous process interface systems. The proprietary input/output communication between the conventional controller CPU and the associated input/output racks is replaced with standard real-time data distribution service middleware for providing seamless cross-vendor interoperable communication between the controller and the distributed autonomous process interface systems. The objective of this change is to allow flexibility of supply for all controller’s subcomponents from multiple vendors to safeguard against premature automation obsolescence challenges. Detailed performance analysis was conducted to evaluate the viability of using the standard real-time data distribution service middleware technology in the design of automation controller to replace the proprietary input/output communication. The key simulation measurements to demonstrate its performance sustainability while growing in controller’s size based on the number of input/output signals are communication latency, variation in packets delays, and communication throughput. The overall performance results confirm the viability of the new proposal as the basis for designing cost effective evergreen process automation solutions that would result in optimum total cost of ownership capital investment throughout the systems’ life span. The only limiting factor is the selected network infrastructure.
Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers
Authors: Morrison Joly Meghan , Hicks Donna J. , Jones Bayley , Sanchez Violeta , Estrada Monica Valeria , Young Christian , Williams Michelle , Rexer Brent N. , Sarbassov Dos D. , Muller William J. , Brantley-Sieders Dana , Cook Rebecca S. 
Published: April 2016

Abstract
HER2 overexpression drives Akt signaling and cell survival and HER2-enriched breast tumors have a poor outcome when Akt is upregulated. Akt is activated by phosphorylation at T308 via PI3K and S473 via mTORC2. The importance of PI3K-activated Akt signaling is well documented in HER2-amplified breast cancer models, but the significance of mTORC2-activated Akt signaling in this setting remains uncertain. We report here that the mTORC2 obligate cofactor Rictor is enriched in HER2-amplified samples, correlating with increased phosphorylation at S473 on Akt. In invasive breast cancer specimens, Rictor expression was upregulated significantly compared with nonmalignant tissues. In a HER2/Neu mouse model of breast cancer, genetic ablation of Rictor decreased cell survival and phosphorylation at S473 on Akt, delaying tumor latency, penetrance, and burden. In HER2-amplified cells, exposure to an mTORC1/2 dual kinase inhibitor decreased Akt-dependent cell survival, including in cells resistant to lapatinib, where cytotoxicity could be restored. We replicated these findings by silencing Rictor in breast cancer cell lines, but not silencing the mTORC1 cofactor Raptor (RPTOR). Taken together, our findings establish that Rictor/mTORC2 signaling drives Akt-dependent tumor progression in HER2-amplified breast cancers, rationalizing clinical investigation of dual mTORC1/2 kinase inhibitors and developing mTORC2-specific inhibitors for use in this setting. Cancer Res; 76(16); 4752–64. ©2016 AACR.
The day range and home range of the Eastern Hoolock Gibbon Hoolock leuconedys (Mammalia: Primates: Hylobatidae) in Lower Dibang Valley District in Arunachal Pradesh, India
Authors: Sarma Kuladip , Kumar Awadhesh 
Published: April 2016

This paper presents the findings of a study conducted on the Eastern Hoolock Gibbon Hoolock leuconedys in Mehao Wildlife Sanctuary and outside to the south of the park, Arunachal Pradesh, India investigating the daily path length (DPL) and home range used by the species in two forest areas with different disturbance gradients. The four habituated groups of H. leuconedys in fragmented and contiguous forest areas, two groups in each of the forest types, showed considerable variation in their DPL ranging from 6.59m to 1019.01m with a mean distance of 192.75m (SE = ±26.48) in 73 full day observations. Although the mean DPL was recorded with very little variation across the seasons in both the forest types, it was significantly different from fragmented forest. Similarly, the home range size also varied among the groups and was estimated as the maximum for Group D (24.62ha) followed by Group E (16.28ha) in contiguous forest and Group B (2.49ha) and Group A (1.09ha) in fragmented forest. Also, there was a distinct seasonal pattern of home range used by all the study groups with largest seasonal home range in monsoon and pre-monsoon season in fragmented and contiguous forest respectively. The DPL and home range of H. leuconedys in Arunachal Pradesh has been highly affected by forest fragmentation and/or canopy discontinuity which makes the species vulnerable to hunting, predation by feral dogs and hawks and ultimately local extinction. Thus, the findings of the present research evoke the question of long term survival of the species in fragmented forests.
Parasitoids (Hymenoptera) of leafminer flies (Diptera: Agromyzidae) from Bangladesh
Authors: Mazumdar Santosh , Bhuiya Badrul Amin 
Published: April 2016

The objective of this study was to determine hymenopteran parasitoids attacking leafminers (Agromyzidae: Diptera) in Bangladesh. Four parasitoid species, viz. Chrysocharis pentheus (Walker), Neochrysocharis formosa (Westwood) and Cirrospilus sp. belonging to family Eulophidae and Opius sp. under family Braconidae of the order Hymenoptera are reported as new to the fauna of Bangladesh. All parasitoids were reared from three agromyzid flies namely Liriomyza sativae Blanchard, Melanagromyza obtusa Mallochand and Ophiomyia phaseoli (Tryon).
Analyzing Evolutionary Optimization in Noisy Environments
Authors: Qian Chao , Yu Yang , Zhou Zhi-Hua 
Published: April 2016

Many optimization tasks must be handled in noisy environments, where the exact evaluation of a solution cannot be obtained, only a noisy one. For optimization of noisy tasks, evolutionary algorithms (EAs), a type of stochastic metaheuristic search algorithm, have been widely and successfully applied. Previous work mainly focuses on the empirical study and design of EAs for optimization under noisy conditions, while the theoretical understandings are largely insufficient. In this study, we first investigate how noisy fitness can affect the running time of EAs. Two kinds of noise-helpful problems are identified, on which the EAs will run faster with the presence of noise, and thus the noise should not be handled. Second, on a representative noise-harmful problem in which the noise has a strong negative effect, we examine two commonly employed mechanisms dealing with noise in EAs: reevaluation and threshold selection. The analysis discloses that using these two strategies simultaneously is effective for the one-bit noise but ineffective for the asymmetric one-bit noise. Smooth threshold selection is then proposed, which can be proved to be an effective strategy to further improve the noise tolerance ability in the problem. We then complement the theoretical analysis by experiments on both synthetic problems as well as two combinatorial problems, the minimum spanning tree and the maximum matching. The experimental results agree with the theoretical findings and also show that the proposed smooth threshold selection can deal with the noise better.
Objective Airport Warnings over Small Areas Using NLDN Cloud and Cloud-to-Ground Lightning Data
Authors: Holle Ronald L. , Demetriades Nicholas W. S. , Nag Amitabh 
Published: April 2016

AbstractLightning can have a significant impact on ground-crew and other operations at airports, resulting in a cascade of delays beyond the immediate locations. Measures of these impacts have not been presented previously in a comprehensive approach for a variety of factors. Prior approaches typically used lightning data within outer observation radii of varying sizes to anticipate cloud-to-ground (CG) flashes in a smaller inner warning area such as an airport. The goal of this paper is to address issues related to the balance between safety and the efficiency of lightning warnings for such situations. The first of two topics addressed in this study is to examine the value of adding cloud pulses to CG strokes. The detection efficiency of the U.S. NLDN for cloud pulses increased to about 50% by late summer 2013, so NLDN data during the entire 2014 summer are considered at 10 locations. Verification is performed for the occurrence of NLDN-detected CG strokes at the airports. Cloud pulses were found to improve the 2-min probability of detection by 13% compared with CG strokes only. The second topic of the study is the reduction of the inner warning area from the size of an entire airport to a small section of the airport, from a radius of 4.8 to 0.5 km. The probability of detection with a 2-min lead time increases to over 0.90 for the smaller area, while the false alarm ratio also increases substantially when CGs plus cloud pulses are included.