bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Lupus Impact Tracker in an Australian patient cohort
Authors: Antony A , Kandane-Rathnayake R K , Ko T , Boulos D , Hoi A Y , Jolly M , Morand E F 
Published: August 2016

Objectives The objective of this article is to validate the Lupus Impact Tracker (LIT), a disease-specific patient-reported outcome (PRO) tool, in systemic lupus erythematosus (SLE) patients in a multi-ethnic Australian cohort. Methods Patients attending the Monash Lupus Clinic were asked to complete the LIT, a 10-item PRO. Psychometric testing assessing criterion validity, construct validity, test-retest reliability (TRT) and internal consistency reliability (ICR) were performed. We compared the LIT scores across patient characteristics, and correlations between LIT scores and SLEDAI-2k, PGA, and SLICC-SDI were examined. Results LIT data were obtained from 73 patients. Patients were 84% female with a median age of 41 years, and 34% were Asian. The cohort had mild-moderate disease activity with a median (IQR) Systemic Lupus Erythematosus Disease Activity Index-2000 (SLEDAI-2k) of 4 (IQR 2–6). The median LIT score was 32.5 (IQR 17.5–50). LIT demonstrated criterion validity against SLEDAI-2k and SDI. Construct validity assessed by confirmatory factor analysis demonstrated an excellent fit (Goodness of fit index 0.95, Comparative Fit Index 1, Root Mean Square Error of Approximation <0.0001). The LIT demonstrated TRT with an overall intraclass correlation coefficient of 0.986 (95% CI 0.968–0.995). ICR was demonstrated with a Cronbach’s alpha of 0.838. Patients with disability, low socioeconomic status, or higher disease activity had significantly worse LIT scores. Conclusion The LIT demonstrated properties consistent with its being valid in this population. Lower socioeconomic status appears to have a significant impact on patient-reported health-related quality of life in SLE.
Adolescents’ health choices related rights, duties and responsibilities: An integrative review
Authors: Moilanen Tanja , Pietilä Anna-Maija , Coffey Margaret , Kangasniemi Mari 
Published: August 2016

Background: Although the link between adolescents’ health choices in relation to rights, duties and responsibilities is acknowledged, little is studied in this subject. Aim: To identify, describe and synthesize previous studies on adolescents’ health choices in relation to rights, duties and responsibilities. Ethical considerations: Ethical approval is not needed as it is an integrative review of published literature. Method: The integrative review was used to review and synthesize current knowledge. Electronic and manual searches from 2009 to March 2014 were used to systematically identify earlier studies. Results: The review identified 13 studies. Adolescents’ health choices were linked to unsuccessfully exercised rights, arising from questioned autonomy and freedom, and their duties were hardly mentioned. Conclusion: Research into adolescents’ health choices in relation to their rights, duties and responsibilities is still methodologically fragmented. In future, more research is needed to support adolescents’ health promotion initiatives and increase their involvement opportunities.
Lessons learned from nurses’ requests for ethics consultation: Why did they call and what did they value?
Authors: Bartlett Virginia L , Finder Stuart G 
Published: August 2016

Background: An ongoing challenge for clinical ethics consultation is learning how colleagues in other healthcare professions understand, make use of, and evaluate clinical ethics consultation services. Aim: In pursuing such knowledge as part of clinical ethics consultation service quality assessment, clinical ethics consultation services can learn important information about the issues and concerns that prompt colleagues to request ethics consultation. Such knowledge allows for greater outreach, education, and responsiveness by clinical ethics consultation services to the concerns of clinician colleagues. Design: This quality assessment project explores consultation requests and follow-up questionnaire responses voluntarily submitted from nurses who requested clinical ethics consultation. We present qualitative data analyzed using content analysis and constant comparison methods to identify key concerns that prompted requests as well as common themes among nurse requestors’ evaluations of what was most important in clinical ethics consultations. Participants and context: A total of 41 nurses requesting clinical ethics consultation and 15 who returned the follow-up questionnaire. Ethical considerations: Our Office of Research Compliance and Quality Improvement determined that our project was not considered human subjects research and so did not require institutional review board approval or exemption. However, efforts were made to avoid any sense of coercion and all data were de-identified prior to analysis. Findings: Our analysis revealed six main categories of issues that prompted nurses’ requests for ethics consultation, as well as unifying themes around nurses’ experiences, advocacy, and family support while caring for patients in the intersections of patients, families, and physicians. Discussion: The insights gained from analyzing nurses’ requests for and responses to clinical ethics consultation may serve as a resource for clinical ethics consultation services seeking to identify, respond to, and educate regarding issues of importance to nurse colleagues and may be a resource for nursing administrators and leadership seeking to identify and address common ethical issues nurses face. Conclusion: Ongoing work on clinical ethics consultation service quality improvement and engagement with our nursing colleagues about their concerns prompting—and their evaluations of—clinical ethics consultation are necessary.
Variations in Strategies to Prevent Ventriculostomy-Related Infections
Authors: Lewis Ariane , Czeisler Barry M. , Lord Aaron S. 
Published: August 2016

Background and Purpose: The ideal strategy to prevent infections in patients with external ventricular drains (EVDs) is unclear. Methods: We conducted a cross-sectional survey of members of the Neurocritical Care Society on infection prevention practices for patients with EVDs between April and July 2015. Results: The survey was completed by 52 individuals (5% response rate). Catheter selection, use of prolonged prophylactic systemic antibiotics (PPSAs), cerebrospinal fluid (CSF) collection policies, location of EVD placement, and performance of routine EVD exchanges varied. Antibiotic-impregnated catheters (AICs) and conventional catheters (CCs) were used with similar frequency, but no respondents reported routine use of silver-impregnated catheters (SICs). The majority of respondents were either neutral or disagreed with the need for PPSA with all catheter types (CC: 75%, AIC: 85%, and SIC: 87%). Despite this, 55% of the respondents reported PPSAs were routinely administered to patients with EVDs at their institutions. The majority (80%) of the respondents reported CSF collection only on an as-needed basis. The EVD placement was restricted to the operating room at 27% of the respondents’ institutions. Only 2 respondents (4%) reported that routine EVD exchanges were performed at their institution. Conclusion: Practice patterns demonstrate that institutions use varying strategies to prevent ventriculostomy-related infections. Identification and further study of optimum care for these patients are essential to decrease the risk of complications and to aid development of practice standards.
Diabetes-related lower extremity amputations in Singapore
Authors: Ang Yee , Yap Chun Wei , Saxena Nakul , Lin Lee-Kai , Heng Bee Hoon 
Published: August 2016

Background: Lower extremity amputation (LEA) is defined as the complete loss in the transverse anatomical plane of any part of the lower limb. The objective of this study is to look at the trend and mortality trend of LEA performed in diabetes patients from 2008 to 2013. Methods: All patients age 15 and above with diabetes mellitus who had undergone LEAs (both major and minor) in Tan Tock Seng Hospital, Singapore from 1 January 2008 to 31 December 2013 were included. The outcomes of interest were deaths from all causes within 30 days and within 1 year. Results: Major LEA rate has increased from 11.0 per 100,000 population in 2008 to 13.3 per 100,000 population in 2013. The 30-day mortality rate ranges from 6.0% to 11.1% and the 1-year mortality rate ranges from 24.3% to 30.6%. Minor LEA rate has increased from 10.8 per 100,000 population in 2008 to 13.9 per 100,000 population in 2013. The 30-day mortality rate ranges from 1.5% to 3.7% and the 1-year mortality rate ranges from 9.7% to 18.3%. Conclusions: The trends in major and minor LEA are increasing. The 30-day and 1-year mortality for both major and minor LEA are comparable to figures reported worldwide. There is a need to re-look at preventive strategies to reduce LEA in diabetes patients in Singapore.
Clonal selection and double-hit events involving tumor suppressor genes underlie relapse in myeloma
Authors: Weinhold Niels , Ashby Cody , Rasche Leo , Chavan Shweta S. , Stein Caleb , Stephens Owen W. , Tytarenko Ruslana , Bauer Michael A. , Meissner Tobias , Deshpande Shayu , Patel Purvi H. , Buzder Timea , Molnar Gabor , Peterson Erich A. , van Rhee Frits , Zangari Maurizio , Thanendrarajan Sharmilan , Schinke Carolina , Tian Erming , Epstein Joshua , Barlogie Bart , Davies Faith E. , Heuck Christoph J. , Walker Brian A , Morgan Gareth J. 
Published: August 2016

Key PointsHits in driver genes and bi-allelic events affecting tumor suppressors increase apoptosis resistance and proliferation rate–driving relapse. Excessive biallelic inactivation of tumor suppressors in high-risk cases highlights the need for TP53-independent therapeutic approaches.
A Focus Group Exploration of Automated Case‐Finders to Identify High‐Risk Heart
Failure Patients within an Urban Safety- Net Hospital
Authors: Patterson Mark E. , Miranda Derick , Schuman Gregory L. , Eaton Christopher M. , Smith Andrew J. , Silver Brad 
Published: August 2016

Background: Leveraging ‘big data’ as a means of informing cost-effective care
holds potential in triaging high-risk heart failure patients for interventions within
hospitals seeking to reduce 30-day readmissions.Objective: Explore provider’s beliefs
and perceptions about using an EHR-based tool that uses unstructured clinical notes to
risk-stratify high-risk heart failure patients.Methods: Six providers from an inpatient
heart failure clinic within an urban safety-net hospital were recruited to participate
in a semi-structured focus group. A facilitator led a discussion on the feasibility and
value of using an EHR-tool driven by unstructured clinical notes to help identify
high-risk patients. Data collected from transcripts were analyzed using a thematic
analysis that facilitated drawing conclusions clustered around categories and
themes.Results: From six categories emerged two themes: 1) challenges of finding valid
and accurate results; and 2) strategies used to overcome these challenges. Although
employing a tool that uses EMR unstructured text as benchmark by which to identify
high-risk patients is efficient, choosing appropriate benchmark groups could be
challenging given the multiple causes of readmission. Strategies to mitigate these
challenges include establishing clear selection criteria to guide benchmark group
composition, and quality outcome goals for the hospital.Conclusion: Prior to
implementing into practice an innovative EMR-based case-finder driven by unstructured
clinical notes, providers are advised to 1) define patient quality outcome goals, 2)
establish criteria by which to guide benchmark selection, and 3) verify the tool’s
validity and reliability. Achieving consensus on these issues would be necessary for
this innovative EHR-based tool to effectively improve clinical decision making and in
turn, decrease readmissions for high-risk patients.
Introduction of an Area Deprivation Index Measuring Patient Socio-economic Status
in an Integrated Health System: Implications for Population Health
Authors: Knighton Andrew J. , Savitz Lucy , Belnap Tom , Stephenson Brad , VanDerslice James 
Published: August 2016

Introduction: Intermountain Healthcare is a fully integrated delivery system based
in Salt Lake City, Utah. As a learning healthcare system with a mission of performance
excellence, it became apparent that population health management and our efforts to move
towards shared accountability would require additional patient-centric metrics in order
to provide the right care to the right patients at the right time. Several European
countries have adopted social deprivation indices in measuring the impact that social
determinants can have on health. Such indices provide a geographic, area-based measure
of how socioeconomically deprived residents of that area are on average. Intermountain’s
approach was to identify a proxy measure that did not require front-line data collection
and could be standardized for our patient population, leading us to the area deprivation
index or ADI. This paper describes the specifications and calculation of an ADI for the
state of Utah. Results are presented along with introduction of three use cases
demonstrating the potential for application of an ADI in quality improvement in a
learning healthcare system.Case Description: The Utah ADI shows promise in providing a
proxy for patient-reported measures reflecting key socio-economic indicators useful for
tailoring patient interventions to improve health care delivery and patient outcomes.
Strengths of this approach include a consistent standardized measurement of social
determinants, use of more granular block group level measures and a limited data capture
burden for front-line teams. While the methodology is generalizable to other
communities, results of this index are limited to block groups within the state of Utah
and will differ from national calculations or calculations for other states. The use of
composite measures to evaluate individual characteristics must also be approached with
care. Other limitations with the use of U.S. Census data include use of estimates and
missing data.Conclusion: Initial applications in three meaningfully different areas of
an integrated health system provide initial evidence of its broad applicability in
addressing the impact of social determinants on health. The variation in socio-economic
status by quintile also has potential for clinical significance, though more research is
needed to link variation in ADI with variation in health outcomes overall and by disease
type.
Screening Method for M-Proteins in Serum Using Nanobody Enrichment Coupled to MALDI-TOF Mass Spectrometry
Authors: Kohlhagen Mindy C , Barnidge David R , Mills John R , Stoner Joshua , Gurtner Kari M , Liptac Andrea M , Lofgren Denise I , Vanderboom Patrick M , Dispenzieri Angela , Katzmann Jerry A , Willrich Maria A V , Snyder Melissa R , Murray David L 
Published: August 2016

Abstract

BACKGROUND
Current recommendations for screening for monoclonal gammopathies include serum protein electrophoresis (PEL), imunofixation electrophoresis (IFE), and free light chain (FLC) ratios to identify or rule out an M-protein. The aim of this study was to examine the feasibility of an assay based on immunoenrichment and MALDI-TOF-MS (MASS-SCREEN) to qualitatively screen for M-proteins.

METHODS
Serum from 556 patients previously screened for M-proteins by PEL and IFE were immunopurified using a κ/λ-specific nanobody bead mixture. Following purification, light chains (LC) were released from their heavy chains by reduction. MALDI-TOF analysis was performed and the mass-to-charge LC distributions were visually examined for the presence of an M-protein by both unblinded and blinded analysts.

RESULTS
In unblinded analysis, MASS-SCREEN detected 100% of the PEL-positive samples with an analytical sensitivity and specificity of 96% and 81% using IFE positivity as the standard. In a blinded analysis using 6 different laboratory personnel, consensus was reached in 92% of the samples. Overall analytical sensitivity and specificity were reduced to 92% and 80%, respectively. FLC ratios were found to be abnormal in 28% of MASS-SCREEN–negative samples, suggesting FLC measurements need to be considered in screening.

CONCLUSIONS
MASS-SCREEN could replace PEL in a panel that would include FLC measurements. Further studies and method development should be performed to validate the clinical sensitivity and specificity and to determine if this panel will suffice as a general screen for monoclonal proteins.
Digitalization as formalization: A view from below
Authors: Parthasarathi Vibodh , Amanullah Arshad , Koshy Susan 
Published: August 2016

Abstract
Like any technology-related choice, digitalization contribu tes to, inter alia, streamlining and standardization in the TV industry, thereby leading to formalization of an industry as a whole and creating new configurations of interest. If digitalization, at any stage, level or place in the value chain, is made mandatory it will not only accelerate this transition but, more significantly, define the very personality of formalization. This article delves into the least explored area in the otherwise exploding research on television in India: the field of distribution. It paints a textured picture of the ways in which the informal business of distribution in the city of Patna was engulfed in the regulatory warp and weft of mandatory digitalization. The article argues that regulatory interventions to formalize this ‘primitive’ segment of the television economy led to reorganizing the balance of interests in the emergent ecology of digital television in India.
News televisions’ impact on political discourse in the Indian election 2014
Authors: Ranganathan Maya 
Published: August 2016

Abstract
The Indian national election of 2014 has been studied intensely mainly because of the scale of the Bharatiya Janata Party (BJP) victory and the ingenious ways new technologies were employed for political communication. The role of news television in democratic politics has been questioned in the context of Indian media’s unbridled efforts towards profit-maximization since private television began in the 1990s, and the impact of these efforts on media credibility. This article asserts that television still shapes and directs political discourse, even in the age of new technologies, but that the role of news television in political communication needs to be rethought. It argues that the evaluation of news television’s agenda setting functions must be placed not only within the context of the dramatic changes that have swept the Indian media landscape but within broader changes in the political and social environments. A critical discourse analysis of Frankly Speaking, the popular weekly political interviews shown on the English news channel Times Now, reveals the subtle ways by which television transfers salience from the media’s agenda to the public agenda.
Gender, generation and reception of Spanish television fiction in the digital age
Authors: Lacalle Charo , Pujol Cristina 
Published: August 2016

Abstract
Media convergence has considerably modified television-viewing practices. The interaction of the television with second screens has generated new ways of communicating between viewers, which they do while simultaneously watching television. This study combines focus groups and questionnaires to examine, from a generational perspective, the relationship between female viewers and Spanish television fiction and the resulting interactions conducted both face-to-face and through new technologies. The results question the view that female members of the digital generation interviewed watch media products in isolation and demonstrate that the social aspect of television viewing is one of its greatest pleasures. In general terms, our contribution confirms the influence of the generation gap on viewers’ preferences and their different ways of watching television. Therefore, the solidarity established between women to maintain and prolong viewing pleasure helps to mitigate the digital gap between older and younger female participants.
Reviews
Authors: Hintz Arne , Loisen Jan , Donders Karen , Starks Michael 
Published: August 2016

Abstract
The Data Revolution: Big Data, Open Data, Data Infrastructures & Their Consequences, Rob Kitchin (2014) London: Sage, 240 pp. ISBN: 9781446287484, p/bk, £22.95
The Contradictions of Media Power, Des Freedman (2014) London: Bloomsbury, 192 pp. ISBN: 9781849660693, p/bk, £19.99
Media Power and Plurality. From Hyperlocal to Highlevel Policy, Steven Barnett and Judith Townsend (Eds) (2015) London: Palgrave Macmillan, 228 pp. ISBN: 9781137522832, h/bk, £60
Human development index of Turkey, economic development, relationship nutrition and comparison with selected countries<p>Türkiye’nin insani gelişme endeksi, ekonomik gelişmişlik, beslenme ilişkisi ve farklı ülkelerle karşılaştırılması
Authors: Mutlu Öztürk Hande 
Published: August 2016

In this study, relationship of human development index, economic development and nutrition was evaluated. Data of Turkey, Norway, Korea, Italy, Greece, Bulgaria, Iran and the United States was compared. General situation in Turkey is evaluated and Solution proposals was presented. In the study, economic size and geographical proximity and similar features with Turkey, high Human Development Indexed countries was selected to compare with many parameters. Comparisons of the countries in terms of human development index and nutritional deficiency, showed similar characteristics with Iran, however, Turkey is dissociated from European countries, Korea and the US. As a result, the economic development level of countries have not seen that much more accurate results in the comparison of the human development index. ÖzetBu çalışmada insani gelişme endeksi, ekonomik gelişmişlik ve beslenme ilişkisi değerlendirilmiştir. Türkiye, Norveç, Kore, İtalya, Yunanistan, Bulgaristan, İran ve Amerika’ya ait veriler karşılaştırılmıştır. Türkiye’nin genel durumu değerlendirilmiş ve çözüm önerileri sunulmuştur. Çalışmada, Türkiye ile ekonomik büyüklük ve coğrafi yakınlık gibi özellikleri benzer ülkeler ve insani gelişmişlik endeksi yüksek olan ülkeler birçok parametre için karşılaştırılmıştır. Karşılaştırmalar, ülkemizin insani gelişmişlik endeksi ve beslenme yetersizliği açısından, İran ile benzer özellikler gösterdiğini ancak Avrupa ülkeleri, Kore ve ABD’den ayrıştığını göstermiştir. Sonuç olarak, ekonomik kalkınmışlık seviyesinin değil ülkeleri karşılaştırmada insani gelişmişlik endeksinin çok daha doğru sonuçlar verdiği görülmüştür.
Analysis of Small Building Plots in Areas with High Density of Building
Authors: Kaczorek K. M. 
Published: August 2016

Abstract Author explains a necessity of supply optimization to construction sites with small storage areas. This paper takes account of conditions existing in Poland. From among all factors discussed by the author, first of all, we should point at construction works on plots located in densely built-up areas, obtained by demolition of existing buildings, as well as a necessity of plots utilization after demolished buildings that technical conditions do not allow for further exploitation.