bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemetric multi-sensor system for medical applications – The approach
Authors: Weidenmüller Jens , Walk Christian , Dogan Özgü , Gembaczka Pierre , Stanitzki Alexander , Görtz Michael 
Published: December 2016

Abstract
Long-term monitoring of hemodynamics can be achieved by an implantable and telemetric multi-sensor system. A concept to realize
a system with high miniaturization level is presented. The requirements regarding a multifunctional transponder ASIC (application
specific integrated circuit), which should combine signal processing, telemetric communication and additional sensors in one chip, are
introduced. Capacitive pressure sensors showing low power consumption were tested with laboratory setups with respect to the
integration in this concept. First results were achieved and discussed concerning two potential assembly technologies for the
integration of a pressure sensor. Finally, hermetic sealing and implant encapsulation technologies are proposed for further implant
miniaturization.
Calibration and uncertainty analysis for multicomponent force/torque measurements
Authors: Schleichert Jan , Rahneberg Ilko , Marangoni Rafael R. , Fröhlich Thomas 
Published: December 2016

Abstract
Many applications in research and industry require accurate
measurements of force and torque
vectors
G. Schicker, R. Wegener.
Drehmoment richtig messen.
Hottinger-Baldwin-Messtechnik, 2002; R. Schwartz.
Teil B: Sensoren, Kraft, Masse, Drehmoment.
In H.-J. Gevatter and U. Grünhaupt, editors, Handbuch der
Mess- und Automatisierungstechnik in der Produktion, VDI-Buch, pages 55–92. Springer, Dordrecht, 2006.
as well as their time
dependency. This measurement task can be solved by using
multicomponent sensors. Despite of their wide distribution there is
a lack of official guides for their calibration
D. Schwind and H. Raabe.
A new Calibration Procedure for Multicomponent transducers.
XX IMEKO World Congress, Metrology for Green Growth, Busan,
Republic of Korea, September 9–12, 2012.
and methods for evaluation of measurement uncertainty. In many
applications statically calibrated mulicomponent sensors are used for
measurement of dynamic quantities
Y.-K. Park, R. Kumme, and D.-I. Kang.
Dynamic investigation of a binocular six-component force-moment
sensor.
Measurement Science and Technology, 13(8):1311–1318, 2002.
which causes severe
deviations in measurement when the quantity to be measured has
a frequency near or above resonance frequency of the transducer. This
paper describes the static calibration and a method for uncertainty
analysis using the example of a six-component sensor for force and
torque. Subsequently the dynamic calibration of such a sensor is
discussed. Based on the results of the dynamic calibration an approach
for evaluation of dynamic measurement uncertainty is applied.
UVB-irradiated indole-3-acetic acid induces apoptosis via caspase activation
Authors: Kwon Nyoun Soo , Jeong Yun-Mi , Jeong Hyo-Soon , Kim Myo-Kyoung , Min Young Sil , Yun Hye-Young , Baek Kwang Jin , Kim Dong-Seok 
Published: December 2016

Abstract

Objective
Indole-3-acetic acid (IAA) activation has been suggested as a new strategy for cancer therapy. It has been reported that ultraviolet B (UVB) radiation can activate IAA. In the present study, we investigated whether UVB-irradiated IAA (IAAUVB) can induce apoptosis of G361 human melanoma cells and examined the apoptotic pathway involved.

Methods
DNA fragmentation was measured to examine apoptosis. IAAUVB-induced signaling pathways were investigated by Western blot analysis.

Results
Our results show that IAAUVB reduced cell viability of G361 human melanoma cells, and induced DNA fragmentation, a hallmark of apoptosis. We also found that c-Jun NH2-terminal kinase (JNK) and p38, which are activated by IAAUVB, are not associated with this cell death. We further investigated the IAAUVB-mediated apoptotic pathway after pretreatment with NS398, vitamin C, and N-acetylcysteine (NAC). Although NS398, an inhibitor of cyclooxygenase-2, was not protective, vitamin C and NAC ameliorated IAAUVB-mediated cell death. In addition, when cells were pretreated with a caspase inhibitor, IAAUVB-induced apoptosis was inhibited.

Conclusions
These results suggest that free radicals generated from IAA by UV irradiation may cause apoptosis, and IAAUVB induces apoptosis of G361 human melanoma cells by activating caspases.
On the production of metaphors and metonymies by Jordanian EFL learners: acquisition and implications
Authors: Zibin Aseel 
Published: December 2016

AbstractThis study explores the ability of Jordanian learners of English as a foreign language (EFL) to produce English metaphorical and metonymical expressions, using a completion task. It also examines whether the use of conceptual and linguistic knowledge of the participants’ first language, i.e. Jordanian Arabic (JA) would facilitate the production task. The study adopts a contrastive model to compare and contrast figurative devices in English and JA, consisting of six types that vary in relation to the conceptual bases and linguistic expressions involved. The results reveal that even though the participants’ scores were poor, the participants exhibited a general capacity to produce metaphorical/metonymical expressions that are similar in meaning to the ones required on the test, utilizing their L1 conceptual and linguistic knowledge. It was suggested that three important factors need to be satisfied to enable EFL learners to produce English figurative devices correctly, i.e. knowledge of the conceptual bases involved, a good command of English collocational knowledge and familiarity with the concept of partial synonymy, and continuous exposure to the figurative expressions in real-life English. Based on these results, the study proposes some pedagogical implications that may assist EFL learners to familiarize themselves with metaphorical/metonymical expressions in English and it concludes with recommendations for further research.
The Demographic Success of Marsilea Quadrifolia L. in a Man-Made Water Body from Danube Delta Biosphere Reservation
Authors: Strat Daniela 
Published: December 2016

AbstractMarsilea quadrifolia L. (water clover) is a unique species from Romanian flora that belongs to the Marsileaceae family and is one of the most vulnerable plants in Europe due to the loss of its habitats. In this paper, the demographic evolution of a new M. quadrifolia population in the Danube Delta Biosphere Reserve and its natural and anthropic threats are reported. The aquatic fern, M. quadrifolia, has colonized a suitable man-made water body. After a decade of monitoring, the demographic trend is positive but the support capacity of habitat for the water clover remains limited in the long term. The population is vulnerable due to succession of vegetation and its vicinity with a human settlement. The establishment of a micro-reserve represents a suitable method to protect and maintain this threatened M. quadrifolia population.
Sabanejewia Aurata (De Filippi, 1863) Populations Management Decisions Support System for Rosci0132 (Olt River Basin)
Authors: Curtean-Bănăduc Angela , Cismaş Cristina-Ioana , Bănăduc Doru 
Published: December 2016

Abstract
The ADONIS: CE was used to design a specific management model for the Sabanejewia aurata (De Filippi, 1863) populations. The proposed model is based on this species, in situ identified biological/ecological necessities in relation to the habitats, the conservation status indicators and appropriate management actions and the pressures and threats founded in the study area. Such on species, on habitats and on site based management system was done to complete this approach for ROSCI0132, the other fish species which are living there being treated already in this respect.
Darboux Transformation for Coupled Non-Linear Schrödinger Equation and Its Breather Solutions
Authors: Feng Lili , Yu Fajun , Li Li 
Published: December 2016

AbstractStarting from a 3×3 spectral problem, a Darboux transformation (DT) method for coupled Schrödinger (CNLS) equation is constructed, which is more complex than 2×2 spectral problems. A scheme of soliton solutions of an integrable CNLS system is realised by using DT. Then, we obtain the breather solutions for the integrable CNLS system. The method is also appropriate for more non-linear soliton equations in physics and mathematics.
Hasta no verte Jesús mío: una propuesta alternativa de historicidad de la Revolución Mexicana desde una óptica feminocéntrica
Authors: González Cárdenas Verónica Alejandra 
Published: December 2016

La Revolución Mexicana de 1910 tuvo su origen en la lucha de clases. Campesinos marginados del desarrollo sociopolítico y económico del país se levantaron en armas contra el régimen dictatorial del general Porfirio Díaz. La lucha armada no fue sostenida únicamente por varones, también contó con la participación activa de las soldaderas, quienes han sido invisibilizadas en la historia oficial y en la narrativa de la Revolución.Elena Poniatowska en su novela Hasta no verte Jesús mío, rescata las historias de la gente corriente, las visibiliza y coloca en una dimensión de poder. En este artículo, me propongo analizar la novela con base en la Historia desde Abajo, para mostrar cómo a partir de la construcción del personaje de Jesusa Palancares, la escritora propone una alternativa de historicidad de la Revolución Mexicana desde una óptica feminocéntrica.
TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury
Authors: Liu Yong , Zhou Li-Jun , Wang Jun , Li Dai , Ren Wen-Jie , Peng Jiyun , Wei Xiao , Xu Ting , Xin Wen-Jun , Pang Rui-Ping , Li Yong-Yong , Qin Zhi-Hai , Murugan Madhuvika , Mattson Mark P. , Wu Long-Jun , Liu Xian-Guo 
Published: December 2016

Clinical studies show that chronic pain is accompanied by memory deficits and reduction in hippocampal volume. Experimental studies show that spared nerve injury (SNI) of the sciatic nerve induces long-term potentiation (LTP) at C-fiber synapses in spinal dorsal horn, but impairs LTP in the hippocampus. The opposite changes may contribute to neuropathic pain and memory deficits, respectively. However, the cellular and molecular mechanisms underlying the functional synaptic changes are unclear. Here, we show that the dendrite lengths and spine densities are reduced significantly in hippocampal CA1 pyramidal neurons, but increased in spinal neurokinin-1-positive neurons in mice after SNI, indicating that the excitatory synaptic connectivity is reduced in hippocampus but enhanced in spinal dorsal horn in this neuropathic pain model. Mechanistically, tumor necrosis factor-alpha (TNF-α) is upregulated in bilateral hippocampus and in ipsilateral spinal dorsal horn, whereas brain-derived neurotrophic factor (BDNF) is decreased in the hippocampus but increased in the ipsilateral spinal dorsal horn after SNI. Importantly, the SNI-induced opposite changes in synaptic connectivity and BDNF expression are prevented by genetic deletion of TNF receptor 1in vivoand are mimicked by TNF-α in cultured slices. Furthermore, SNI activated microglia in both spinal dorsal horn and hippocampus; pharmacological inhibition or genetic ablation of microglia prevented the region-dependent synaptic changes, neuropathic pain, and memory deficits induced by SNI. The data suggest that neuropathic pain involves different structural synaptic alterations in spinal and hippocampal neurons that are mediated by overproduction of TNF-α and microglial activation and may underlie chronic pain and memory deficits.SIGNIFICANCE STATEMENTChronic pain is often accompanied by memory deficits. Previous studies have shown that peripheral nerve injury produces both neuropathic pain and memory deficits and induces long-term potentiation (LTP) at C-fiber synapses in spinal dorsal horn (SDH) but inhibits LTP in hippocampus. The opposite changes in synaptic plasticity may contribute to chronic pain and memory deficits, respectively. However, the structural and molecular bases of these alterations of synaptic plasticity are unclear. Here, we show that the complexity of excitatory synaptic connectivity and brain-derived neurotrophic factor (BDNF) expression are enhanced in SDH but reduced in the hippocampus in neuropathic pain and the opposite changes depend on tumor necrosis factor-alpha/tumor necrosis factor receptor 1 signaling and microglial activation. The region-dependent synaptic alterations may underlie chronic neuropathic pain and memory deficits induced by peripheral nerve injury.
Impact of AIP and inhibitory G protein alpha 2 proteins on clinical features of sporadic GH-secreting pituitary adenomas
Authors: Ritvonen Elina , Pitkänen Esa , Karppinen Atte , Vehkavaara Satu , Demir Hande , Paetau Anders , Schalin-Jäntti Camilla , Karhu Auli 
Published: December 2016

Introduction
In sporadic acromegaly, downregulation of AIP protein of the adenomas associates with invasive tumor features and reduced responsiveness to somatostatin analogues. AIP is a regulator of Gai signaling, but it is not known how the biological function of the Gai pathway is controlled.

Aim
To study GNAS and AIP mutation status, AIP and Gai-2 protein expressions, Ki-67 proliferation indices and clinical parameters in patients having primary surgery because of acromegaly at a single center between years 2000 and 2010.

Results
Sixty patients (F/M, 31/29), mean age 49 (median 50), mean follow-up 7.7 years (range 0.6–14.0) underwent primary surgery. Four adenoma specimens (6.8%) harbored an AIP and 21 (35.6%) an activating GNAS (Gsp+) mutation. Altogether 13/56 (23%) adenomas had low AIP protein levels, and 14/56 (25%) low Gai-2 staining. In regression modeling, AIP expression associated with Gai-2 (P = 2.33 × 10−9) and lower Ki-67 (P = 0.04). In pairwise comparison, low AIP protein predicted high GH at last follow-up (mean 7.7 years after surgery, q = 0.045). Extent of treatments given for acromegaly associated with higher preoperative GH (P = 7.94 × 10−4), KNOSP (P = 0.003) and preoperative hypopituitarism (P = 0.03) and remission at last follow-up with change in 3-month postoperative IGF1 (P = 2.07 × 10−7).

Conclusions
We demonstrate, for the first time, that AIP protein expression associates with Gai-2 protein intensities in sporadic somatotropinomas, suggesting a joint regulation on somatostatin signaling. Low AIP level associates with higher proliferative activity and predicts high GH concentrations after long-term follow-up. The AIP mutation rate of 6.8% is fairly high, reflecting the genetic composition of the Finnish population.
Abordagens da Equidade: aproximações sobre um conceito-chave das humanidades e das ciências sociais
Authors: Haeberlin Mártin 
Published: December 2016

O presente texto propõe um exame de diferentes abordagens da equidade, uma vez que, não obstante seja ela um conceito filosófico clássico, devem-se conhecer as visões sobre ela advindas de outras áreas do conhecimento, notadamente o direito e a economia. Para realizar esse objeto, são tratadas as visões de equidade nas seguintes abordagens: o conceito de justiça em Aristóteles; a doutrina do direito de Immanuel Kant; a “justice as fairness” de John Rawls; a igualdade como virtude em Ronald Dworkin; e noção de capacidades e liberdades substantivas de Amartya Sen. Ao fim, realiza-se uma categorização do termo em dois sentidos, propondo-se sua conexão.
Prevention of Internet addiction: A systematic review
Authors: Vondráčková Petra , Gabrhelík Roman 
Published: December 2016

Background and aims
Out of a large number of studies on Internet addiction, only a few have been published on the prevention of Internet addiction. The aim of this study is provide a systematic review of scientific articles regarding the prevention of Internet addiction and to identify the relevant topics published in this area of interest.

Methods
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were adopted. The EBSCO, ProQuest Central, and PubMed databases were searched for texts published in English and Spanish between January 1995 and April 2016. A total of 179 original texts were obtained. After de-duplication and topic-relevance review, 108 texts were systematically classified and subjected to descriptive analysis and subsequent content analysis.

Results
The results of the content analysis yielded the following thematic areas: (a) target groups, (b) the improvement of specific skills, (c) program characteristics, and (d) environmental interventions.

Discussion and conclusion
Literature on the prevention of Internet addiction is scarce. There is an urgent need to introduce and implement new interventions for different at-risk populations, conduct well-designed research, and publish data on the effectiveness of these interventions. Developing prevention interventions should primarily target children and adolescents at risk of Internet addiction but also parents, teachers, peers, and others who are part of the formative environment of children and adolescents at risk of Internet addiction. Newly designed interventions focused on Internet addiction should be rigorously evaluated and the results published.
Palatal Fistula Risk after Primary Palatoplasty
Authors: Daniels Kimberly M. , Yang Yu Emily , Maine Rebecca G. , Heng Yin , Yang Li , Shi Bing , Corlew D. Scott , Hoffman William Y. , Gregory George A. 
Published: December 2016

Background: Humanitarian surgical organizations provide palatoplasties for patients without access to surgical care. Few organizations have evaluated the outcomes of these trips. This study evaluates the palatal fistula rate in patients from two cohorts in rural China and one in the United States. Methods: This study compared the odds of fistula formation among three cohorts whose palates were repaired between 2005 and 2009. One cohort included 97 Chinese patients operated on by teams from the United States and Canada under the auspices of Resurge International. They were compared to cohorts at Huaxi Stomatology Hospital and the University of California San Francisco (UCSF). Age, fistula presence, and Veau class were compared among cohorts using Chi-square tests. Logistic regression was used to analyze predictors of fistula formation. Results: The fistula risk was 35.4% in patients treated by humanitarian teams, 12.8% at Huaxi University Hospital and 2.5% at UCSF ( P < 0.001). Age and Veau class were associated with fistula formation (Age P = 0.0015; Veau P < 0.001). ReSurge and Huaxi patients had 20.2 and 5.6 times the odds of developing a fistula, respectively, compared to UCSF patients ( P < 0.01, both). A multivariable model controlling for surgical group, age, and gender showed an association between Veau class and the odds of fistula formation. Conclusions: Chinese children undergoing palatoplasty by international teams had higher odds of palatal fistula than children treated by Chinese surgeons in established institutions and children treated in the United States. More research is required to identify factors affecting complication rates in low-resource environments.
Transforming Growth Factor Alpha Taq I Polymorphisms and Nonsyndromic Cleft Lip and/or Palate Risk
Authors: Yan Chen , Deng-qi He , Li-ya Chen , Mang Yang , Ke-hu Yang 
Published: December 2016

Background: A series of epidemiological studies were conducted to investigate the association between transforming growth factor alpha ( TGFA) polymorphism and nonsyndromic cleft lip and/or palate (CL/P) risk, but the findings remain conflicting. The present meta-analysis summarizes the association between the TGFA Taq I polymorphisms and nonsyndromic CL/P risk. Methods: We searched PubMed, EMBASE, Web of Science, and Chinese Biomedical Literature databases from their inception to May 1, 2015. Fixed-effects or random-effects models were used to calculate the pooled odds ratio for two genetic comparisons (heterozygous mutation versus wild type, homozygous mutation versus wild type). All of the statistical tests were conducted by STATA 10.0 (StataCorp, College Station, TX). Results: A total of 26 case-control studies were identified for this meta-analysis. There was evidence of a significant association between the TGFA Taq I polymorphism and nonsyndromic CL/P risk in the overall population. The TGFA polymorphism was associated with nonsyndromic CL/P susceptibility in Asian populations under any of genetic models. However, in subgroup analysis, we did not find a significant association of TGFA gene polymorphisms with a reduced cancer risk in White and other populations and (recessive model, odds ratio = 2.37, 95% confidence intervals = 0.92-6.07; odds ratio = 3.45, 95% confidence intervals = 1.07-11.09, respectively). Conclusion: Our study indicates that the TGFA gene polymorphism might be associated with nonsyndromic CL/P susceptibility. However, these findings still need to be confirmed by single, large, well-designed prospective studies.
RELACIÓN ENTRE LA AUTORREGULACIÓN PERSONAL Y LA CONFIANZA ACADÉMICA (PRESAGIO) CON EL ENGAGEMENT-BOURNOUT DE LOS ESTUDIANTES UNIVERSITARIOS (PRODUCTO)
Authors: De la Fuente Jesús , López Mireia , Zapata Lucía , Sander Paul , Putwain Dave 
Published: December 2016

Resumen.Introducción. La autorregulación personal ha sido definida como la capacidad de una persona para planificar, supervisar y dirigir su comportamiento en situaciones de cambio. La confianza académica es un término general que suele considerarse con carácter menos específico de la situación y, como tal, podría ser visto como un constructo de auto-eficacia académica. El Modelo 3P ha establecido diversas variables de presagio, proceso y producto de los alumnos, con una evidencia empírica consistente de estas relaciones. Entre las mismas, la investigación reciente está centrada en el establecimiento del papel de las variables emocionales y sus relaciones con las de carácter motivacional y cognitivo.Método. Un total de 250 estudiantes de la Universidad de Almería (España, correspondientes a segundo y cuarto curso, de Grado y Licenciatura, respectivamente,) participaron en esta investigación. Para la evaluación de la autorregulación personal se evaluó el Cuestionario de Autorregulación, SRQ en su versión española, CARAbreviada y validada en muestras españolas. Para la evaluación de la confianza académica el inventario ABC, validado con muestras españolas. El compromiso-agotamiento se evaluó a través de una versión española validada del Marlach Bournout Inventory Survey-Utrech Work Engegement Scale for Students, con adecuados índices de fiabilidad y validez de constructo. La cumplimentación de los cuestionarios se realizó de manera anónima, en clase y en semanas diferentes. Se utilizo un diseño de investigación de carácter ex post-facto. Los análisis realizados en relación a los objetivos e hipótesis propuestos fueron de asociación (correlaciones bivariadas de Pearson).Resultados. Apareció una relación general de asociación, positiva y significativa, entre la autorregulación personal y la confianza académica (variables presagio) con respecto a al compromiso emocional, engagement (como variable producto), así como negativa con el agotamiento emocional (bournout). También, aparecieron numerosas relaciones significativas específicas.Discusión. Los resultados confirman dos aspectos. De una parte, la relevancia de los modelos 3P y DIDEPRO, como heurísticos consistentes para el análisis del proceso de enseñanza-aprendizaje universitario. De otra, la importancia de las emocionales positivas (engagement) vs. negativas (bournout), asociadas a los constructos autorregulación personal y a la confianza académica.Palabras Clave: Autorregulación personal, confianza académica, engagement, bournout, universidad.
ANÁLISE DA PERCEÇÃO DO CUIDADOR INFORMAL DO DOENTE DEPENDENTE POR ACIDENTE VASCULAR CEREBRAL
Authors: Almeida José Manuel , Sánchez Casado Inmaculada 
Published: December 2016

Resumo.Os Acidentes Vasculares Cerebrais (AVC), são a maior causa de morbilidade e mortalidade prematura nos países desenvolvidos. A sociedade e as alterações dos seus hábitos de vida, têm criado condições ao aparecimento de maior número de AVC, em idade cada vez mais jovens (Branco e Santos, 2010).