bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evolving Paradigm in Borderline Resectable and Locally Advanced Pancreatic Cancer: Current Strategies and Opportunities for the Future
Authors: Zereshkian Arman , Tsang Erica S. 
Published: October 2024

Pancreatic ductal adenocarcinoma (PDAC), a cancer of the gastrointestinal tract, has been increasing in incidence, with an estimated doubling worldwide over the past two decades. Despite increases in awareness and innovations in genomics and drug discovery, 5-year survival remains low, at only 10%. This is in part owing to the majority of patients being diagnosed at the advanced stage of the disease, in addition to chemotherapy recalcitrant disease.
Surgical resection is necessary for a potential cure, however, this is only possible for the 10% of patients who present with resectable disease and potentially for those with borderline resectable disease. Locally advanced pancreatic cancer accounts for approximately 30% of those with PDAC and most of those patients are often precluded from curative intent surgery due to major vascular invasion and local infiltration into peri-pancreatic soft tissue. In cases of locally advanced disease, induction chemotherapy is often used, identifying the subgroup of patients more suited for local treatments and those who may later develop metastases. The treatment regimens used for patients with locally advanced PDAC are often extrapolated from trials involving patients with metastatic disease. In some cases, responses to neoadjuvant therapy have allowed for surgical resection, albeit these aggressive resections were associated with significant morbidity.
There is growing interest in identifying the optimal neoadjuvant treatment for patients with borderline resectable pancreatic cancer (BRPC) and locally advanced PDAC (LAPC) in an effort to improve outcomes. Here we review therapeutic strategies for borderline resectable and locally advanced PDAC, with a focus on novel systemic therapy regimens, chemoradiation, and different radiation modalities.
Tecnologias Digitais na Formação de Professores com ênfase na Produção de Cartoons
Authors: Santos P. A. S. , Santos Elisângela Rodrigues dos , Souto Daise Lago Pereira 
Published: October 2024

Neste artigo, temos como objetivo investigar a percepção dos professores em relação à produção e à utilização de cartoons digitais nos processos de ensino e de aprendizagem. Para tanto, convidamos professores de Ciências e de Matemática da rede pública de ensino do município de Tangará da Serra-MT para uma formação sobre produção de cartoons. Do ponto de vista pedagógico, o intuito foi discutir possibilidades de uso das Tecnologias Digitais (TD) nas práticas pedagógicas. Teoricamente, nos apoiamos nos autores que discutem tecnologias digitais, formação de professores e o uso dos cartoons nos processos de ensino e de aprendizagem. Quanto à metodologia adotada, optamos pela pesquisa de abordagem qualitativa, tendo como instrumentos e procedimentos de produção de dados questionários abertos, entrevistas e observação participante. Os resultados indicaram que os cartoons podem contribuir com os processos de ensino e de aprendizagem, como uma alternativa para possibilitar a integração das Tecnologias Digitais (TD) nas práticas pedagógicas.
OS IMPACTOS DO SEDENTARISMO NO AMBIENTE DE TRABALHO
Authors: Jéssica Conchavo Soares  , Jéssica Pinheiro dos Santos  , Layla Xavier Novais  , Lorena Ferreira Pinheiro  , Marielly da Silva Bulian  , Maxwel Moura Novais  , Rafael Pereira de Moura  , Amanda Figueiredo de Andrade  
Published: October 2024

Os impactos do sedentarismo no ambiente de trabalho é um tema extremamente relevante no cenário brasileiro, sendo necessário discutir acerca da problemática, uma vez que o sedentarismo causa prejuízos tanto para a companhia quanto para os colaboradores. Considerado a doença do milênio, o sedentarismo é definido como um comportamento cotidiano de hábitos decorrentes dos confortos da vida moderna, bem como da falta ou diminuição de atividades físicas. O objetivo do presente trabalho é discutir os impactos do comportamento sedentário na vida dos trabalhadores, apresentando possíveis soluções para diminuir a problemática. O trabalho será realizado a partir de análises de pesquisas bibliográficas, bem como de dados constantes em artigos. Os resultados esperados indicam que, o sedentarismo e o trabalho estão interligados, uma vez que a falta de exercícios (uma das causas do sedentarismo) pode estar associada diretamente ao trabalho que a pessoa exerce. Isso porque, quando o colaborador estressa em excesso o corpo e a mente durante a jornada de trabalho, a tendência é que a sua disposição para a prática de exercícios só diminua. Em decorrência, o sedentarismo pode provocar um grande volume de faltas e licenças médicas na equipe e para suprir as ausências dos colaboradores, a empresa acaba tendo que contratar temporários, gerando gasto com a folha salarial. Concluiu-se que a corporação tem um papel fundamental na saúde dos funcionários, sendo necessário sua intervenção a fim de diminuir o sedentarismo da vida do trabalhador, aumentando, assim, a sua produtividade e, logo, melhorando os resultados que ele apresenta.
USO DE DIFERENTES COAGULANTES À BASE DE TANINO PARA TRATAMENTO DE ÁGUAS SUPERFICIAIS COM ELEVADA CARGA DE SÓLIDOS EM SUSPENSÃO
Authors: Nascimento Rolim dos Santos Cristiane , Martins Ramos Alex 
Published: October 2024

A água é um dos recursos naturais indispensáveis para vida terrestre e principalmente para o consumo humano. Porém, muitas vezes para tornar-se potável, precisa-se passar por processos físicos e químicos para consumos. Uns desses processos é a etapa de coagulação que é método fundamental no tratamento, onde os sólidos são separados da água por decantação por meio de um agente coagulante, que na maioria das vezes é um sal inorgânico como sulfato de alumínio ou ferro, que podem afetar gravemente o meio ambiente se o resíduo for descartado de forma incorreta. Este trabalho teve como objetivo avaliar o potencial de desempenho de coagulantes à base de tanino no tratamento de águas do médio Amazonas. Foram avaliados os parâmetros físico-químicos: pH, cor, turbidez, condutividade elétrica, temperatura e sólidos suspensos totais. Foram preparadas soluções a 1% dos coagulantes Tanfloc SG®️, MTH®️ e MT®️, tratados com volumes pré-determinados de 8, 10, 12, 14 e 20 mL. Os resultados apontaram pouca variação de pH mesmo depois do tratamento com valor entre 6-8, sendo boa para consumo, situação que evita uso de produtos químicos para correção. Os melhores em eficiência, principalmente na remoção da turbidez e manutenção do pH foram os Tanfloc SG®️ (8,0 mL), Tanfloc MTH®️ (14,0 mL) e Tanfloc MT®️ (12,0 mL) com percentual de remoção superior a 95%. Com relação ao tempo de sedimentação, levaram em torno de 35 minutos para sua deposição. Portanto, os coagulantes naturais provenientes de biomoléculas como taninos que foram que analisados têm potencial para substituir os coagulantes inorgânicos e facilitando o descarte do resido final.
Palavras-chave: Coagulante natural; Tanfloc; tratamento de água; variáveis físico-químicas.
La Teoría de la Actividad como Referente de las Prácticas de Colaboración para el Aprendizaje en los Ambientes Virtuales
Authors: Ruiz Aguirre Edith Inés , Martínez de la Cruz Nadia Livier , Galindo González Rosa María 
Published: October 2024

Este artículo es resultado de un análisis documental que fundamenta las bases de la teoría de la actividad para el aprendizaje en las prácticas de colaboración durante la formación de estudiantes en ambientes virtuales de aprendizaje (AVA). Busca establecer teóricamente las formas de ¿cómo los sujetos construyen y estructuran la actividad en los sistemas de colaboración en los AVA? Y ¿Cómo se generan los actos de sentido, las tareas y los actores en la división del trabajo y en las prácticas de colaboración que desarrollan los estudiantes en los diferentes escenarios colaborativos que ofrecen los AVA?. Se reconoce a la teoría de la actividad como explicativa de las relaciones intersubjetivas y los artefactos de mediación como elementos que introducen concepciones que son interiorizados en actos de sentido en los actores sujetos de aprendizaje, donde mediante acciones subjetivas y actividades colectivas explican desde la complejidad los procesos psicológicos derivados de la actividad humana. Y en particular, las prácticas de colaboración como sistema de actividad humana que desarrollan los sujetos, lo que permite establecer relaciones e interacciones con el objeto/objetivos, instrumentos, las reglas y la división de tareas, produciendo nuevas reformulaciones y significados que conducen a un aprendizaje colaborativo.
CAPITAL STRUCTURE AND THE PERFORMANCE OF DEVELOPMENT FINANCE INSTITUTIONS IN NIGERIA
Authors: Ngutor Anyam , Nguwasen Kwahar , Teryima Sev Joseph , Terungwa Jato Paul , Sylvia Sev 
Published: October 2024

The study investigated the effect of capital structure on the performance of selected Development Finance Institutions (DFIs) in Nigeria. The study specifically examined the effect of Total Debt to Total Assets (TDTA) on performance of selected of development finance institutions in Nigeria; and ascertained the effect of Total Debt to Total Equity (TDTE) on performance of selected development finance institutions in Nigeria. The study adopted an ex-post facto research design and data were collected from published annual financial records of the selected DFIs on both TDTA and TDTE, the independent variables and Return on Assets (ROA), the dependent variable, for a period of ten (10) years (2013-2022). The population of the study composed of seven (7) national DFIs namely: Central Bank of Nigeria (CBN), Bank of Agriculture (BOA), Bank of Industry (BOI), Development Bank of Nigeria (DBN), Federal Mortgage Bank of Nigeria (FMBN), Nigeria-Export-Import Bank (NEXIM) and the Infrastructure Bank Plc (IBN). The study sampled four (4) national DFIs using a purposive sampling technique, including CBN, BOI, FMBN and NEXIM. Computation of the relevant ratios were done for the independent variables (TDTA and TDTE); and the dependent variable (ROA). Data analysis was done using multiple regression and the econometric technique of Dynamic Ordinary Least Squares (DOLS) with the aid of E-Views Version 13. The study found that TDTA has a negative but significant effect on ROA, indicating that a percentage change in TDTA leads to lower ROA by 0.071551 and TDTE has a positive effect of TDTE on ROA, showing that a percentage change in TDTE will significantly increase ROA by 0.001696. The study concluded that the investigated DFIs have low equity capital which seems to hinder their ability to attract large loans for operations. The study recommended amongst others that DFIs should maintain a balanced total debt to total assets (TDTA) and ensure the regular monitoring of the debt-to-asset ratio to ensure it remains within a healthy range which will help maintain a balance between leveraging and risk.
Opportunities and Challenges in Digitalising Marine Logistics in Indonesia
Authors: Kyew Aung Ye 
Published: October 2024

As the largest archipelagic country in the world, Indonesia has great potential in the maritime logistics industry. However, digitalization in this sector still faces challenges such as inadequate information technology infrastructure and a lack of skilled human resources in the digital field. On the other hand, the digitalization of maritime logistics offers opportunities to increase the efficiency, transparency, and traceability of supply chains, as well as reduce operational costs and the risk of goods damage. Collaboration between government, industry, and academia is key in facing challenges and exploiting digitalization opportunities. By overcoming challenges and taking advantage of digitalization opportunities, Indonesia can strengthen its position as an important maritime country and encourage national economic growth through a more efficient and modern maritime logistics industry.
The Effectiveness of Red Ginger To First Trimester In Pregnant Women With Emesis Gravidarum
Authors: Siti Mudrikatin  
Published: October 2024

Nausea and vomiting or emesis gravidarum are symptoms that commonly occur in pregnant women in the firs trimester and are physiological, caused by hormonal changes in pregnant women. The purpose of this study was to determine the effectiveness of giving red ginger water to reduce the frequency of emesis gravidarum in first trimester pregnant women. One Group Pre-Post Test Design research design. The research was conducted in Februari - July 2024 in the working area of the Jabon Public Health Center Jombang. The sample was 60 respondents selected with purposive sampling technique. The instrument used to measure emesis gravidarum is The Rhodes Index Nausea, Vomiting and Retching. Bivariate analysis using the Mann-Whitney test. The average difference in the frequency of emesis gravidarum before and after the intervention of red ginger extract was 3.01 and cardamom water was 2.91. The results of the Mann-Whitney test in which the intervention pretest and posttest intervention pairs of giving red ginger were a p value of 0.000 <0.05. Giving red ginger intervention is effective in reducing the nausea of emesis gravidarum significantly in reducing the frequency of emesis gravidarum.
Penerapan Pregnancy Music (Classic) terhadap Tingkat Kecemasan Ibu Hamil Trimester Iii di BPM Kristin Kota Batam Kepulauan Riau Tahun 2024
Authors: Maria Hestina Nona Yeni  , Vitalia Hanako Murni Simanjuntak  , Juliana Munthe  , Markus Doddy Simanjuntak  
Published: October 2024

According to Mulyani (2018) breast self-examination (BSE) is a breast examination to find abnormal lumps. This examination can be done yourself without having to go to the health center and without having to pay any money. Based on data from the World Health Organization (WHO), the total number of cancer cases in Indonesia in 2020 reached 396,914 cases and the total deaths were 234,511 cases. Cancer prevalence in Indonesia in 2020 was dominated by breast cancer, with 65,858 cancer sufferers (16.6%). The research design used is an analytical type of research to determine the causal relationship between two variables. with a cross sectional approach where data collection for independent variables and dependent variables is carried out at one time only. The population of this study is all teenagers in the Rohana am.keb midwife clinic area. as many as 35 teenagers. The entire research population was used as a sample, data obtained from primary data was analyzed using the chisquare test. Based on the statistical test table, it can be seen that from the chi square test, Knowledge (P=value=0.007) is smaller than sig α (0.05). It is hoped that health workers will pay more attention to young women about the dangers of breast cancer.
Hubungan Pengetahuan Remaja Putri Tentang Pemeriksaan Sadari (Breast Self Examination)
Authors: Rika Mailani  , Vitalia Hanako Murni Simanjuntak  , Lasria Yolivia Aruan  , Khairunnisa Situmorang  
Published: October 2024

According to Mulyani (2018) breast self-examination (BSE) is a breast examination to find abnormal lumps. This examination can be done yourself without having to go to the health center and without having to pay any money. Based on data from the World Health Organization (WHO), the total number of cancer cases in Indonesia in 2020 reached 396,914 cases and the total deaths were 234,511 cases. Cancer prevalence in Indonesia in 2020 was dominated by breast cancer, with 65,858 cancer sufferers (16.6%). The research design used is an analytical type of research to determine the causal relationship between two variables. with a cross sectional approach where data collection for independent variables and dependent variables is carried out at one time only. The population of this study is all teenagers in the Rohana am.keb midwife clinic area. as many as 35 teenagers. The entire research population was used as a sample, data obtained from primary data was analyzed using the chisquare test. Based on the statistical test table, it can be seen that from the chi square test, Knowledge (P=value=0.007) is smaller than sig α (0.05). It is hoped that health workers will pay more attention to young women about the dangers of breast cancer.
Hydrate formation and its influence on natural gas pipeline: Simulation study
Authors: Onyejekwe Ifeanyichukwu Michael , Uwaezuoke Nnaemeka , Gborienemi George Ononien , Obibuike Ubanozie Julian , Okoli Nnanna Onwuegbueha 
Published: October 2024

This study simultaneously studied the twin problem of hydrate and corrosion that occurs in natural gas pipelines, establishing their interdependence using a simulation approach. CO2 corrosion was simulated using the NORSOK M-506 standard model in Matlab. Major factors considered are the relationship between corrosion rate and temperature, corrosion rate and PH, corrosion-temperature relationship for varying CO2 mole percent, and PH values. The result from this study established that both type I and type II hydrates could form at the operating conditions of 5OC and 60 bar. The obtained result also shows that the rate of corrosion decreases and increases with an increase in PH values and temperature respectively to a certain temperature of approximately 78 OC, then a dip in the rate of corrosion. The result for the corrosion-temperature relationship for varying PH values and CO2 mole percent shows a decrease in corrosion rate with an increase in PH and an increase with the increase in CO2 mole percent. Furthermore, the obtained results highlight a rise as high as 5.7 mm/year at a 3 mole percent CO2. This value and trend portray a bad omen for the affected pipeline. This study recommends that natural gas to be transported by pipeline should be sweetened and processed to remove H2S, CO2, and mercaptans if present.
Nanomaterials in bacterial detection: current trends and future outlook
Authors: Chaudhary Rashi , Singh N.B. , Nagpal Garima , Saah Fredrick K , Singh Amit Kumar 
Published: October 2024

Contamination by pathogenic bacteria represents a severe risk to public health and well-being. We outlined current approaches to detecting and sensing harmful bacteria by integrating recognition elements with nanomaterials (NMs) in this study. Nanomaterials have emerged as a transformative technology for bacterial detection due to their unique physicochemical properties, including high surface area, quantum effects, and enhanced reactivity. This review highlights the current trends in the application of various nanomaterials, such as gold nanoparticles, carbon nanotubes, and quantum dots, in the detection of bacterial pathogens. These materials enable the development of selective, and rapid detection methods through mechanisms like surface plasmon resonance, electrochemical sensing, and fluorescence. Furthermore, integrating nanomaterials with microfluidic devices and biosensors is discussed, showcasing advancements in point-of-care diagnostics. Challenges such as stability, reproducibility, and potential toxicity of nanomaterials are addressed, alongside regulatory considerations. The future outlook emphasizes the potential of emerging nanomaterials, such as graphene and metal-organic frameworks, to revolutionize bacterial detection. This review aims to enhance the scalability, cost-effectiveness, and environmental sustainability of these technologies, paving the way for widespread clinical and environmental applications.
Challenges Encountered by the Deans, Chairs of the Academic Departments, and the Faculty in Training of Quality Graduates in the Universities
Authors: Kanyiri Ikiara, Lucy 
Published: October 2024

Training of quality graduates in the universities requires a multifaceted approach at all levels of management. Universities having been accredited it is presumed that they have policies in place, appropriate curricula, resources, appropriate management structures, processes, and best management practices to support the training of quality graduates. Deans, Chairs of Academic departments, and faculty are key in ensuring that training of quality graduates is successfully attained by facilitating curriculum development, implementation and leadership, effective teaching and learning, and faculty support. This is made possible by identifying management practices that are important for each key area to ensure effectiveness and efficiency. However, the literature available indicates that Deans, Chairs of Academic departments, and faculty are not able to successfully identify and implement these best management practices due to several challenges encountered in day-to-day activities. These challenges affect the entire process of producing holistic graduates. Therefore, the study set out to establish the challenges encountered by the Deans, Chairs of Departments, and faculty staff in implementing management practices in the universities with a view to training quality graduates. The research used a descriptive survey research design. The target population was the universities in Kenya where six universities were sampled. The study revealed that there exist challenges that limit deans, chairs of departments, and faculty in producing holistic graduates in the universities. Based on the findings there is a need to review policies on staff loading, resource allocation, and institutionalizing rewards systems.
Legal Framework and Financial Corporate Compliance in Public Universities in Kenya
Authors: Chokaa Vincent , Baimwera (PhD) Dr. Bernard , Mugambi (PhD) Dr. Ken , Senaji (PhD) Prof. Thomas A. 
Published: October 2024

One of the important components of corporate governance that improves accountability and transparency in an institution's financial management is financial corporate compliance. The emergence of alarming cases of financial impropriety in Kenya's public universities has intensified the demand for financial accountability in the public sector and exposed the boards and management to increasing scrutiny. Public organizations have reported cases of inadequate or absent financial compliance, and public universities have also cited comparable circumstances in audit reports. It is unclear, however, what the causes of this compliance are or what function corporate governance plays in it. The purpose of this study was to investigate the effect of the legal framework on financial corporate compliance at Kenya's public universities. The study adopted a descriptive survey research design. The study's target population was 40 accredited public universities in Kenya. The data were gathered through the use of extensive, quasi-structured questionnaires. The study used descriptive statistics such as frequency distribution tables, percentages, and measures of central tendency such as the mean. Chi-square and correlation analysis were used to establish the relationship between the study variables. The study discovered that the legal framework had a considerable impact on financial corporation compliance during the study period and had a favorable impact on it. These results show that Kenya's public universities are accredited by the commission on higher education and operate by its rules, which increases financial corporate compliance. The study recommends all public universities to be keeping track of all activities required to be adhered to by the public institution finance department more regularly to ensure the smooth running of the institutions. It is also recommended the university management facilitate regular training for the officers in the finance department to equip them with the relevant information of the newly amended policies by the government to govern the finances used to run public universities.