bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Splinting in Children and Adolescents With Stiffness After Knee Surgery
Authors: Pace James L. , Nasreddine Adam Y. , Simoni Michael , Zurakowski David , Kocher Mininder S. 
Published: February 2016

Purpose:
The purpose of this study was to investigate the indications and outcomes of dynamic splinting (DS) of the arthrofibrotic knee in the pediatric population.

Methods:
Seventy-four patients (41 males, 33 females) with postoperative arthrofibrosis treated with DS after an index knee surgery were reviewed. Median age was 13 years (range, 4 to 18 y), and median follow-up was 17 months (interquartile range, 10 to 28 mo). Demographics, index surgery procedure, preoperative and postoperative knee range of motion (ROM) measurements, treatment length and subsequent need for manipulation under anesthesia (MUA), and surgical lysis of adhesions (LOA) were evaluated. A ROM deficit was defined as lack of extension ≥10 degrees or lack of flexion <130 degrees. Successful improvement of ROM was defined as an increase of ≥10 degrees in flexion, extension, or both. There were 23 patients with flexion deficit only, 17 with extension deficit only, and 34 with combined flexion and extension deficits. Wilcoxon signed-rank test was used to assess median improvement in ROM. Patients were classified into 4 surgical groups: anterior cruciate ligament (ACL) reconstruction without meniscal repair (n=19), ACL reconstruction with meniscal repair (n=12), tibial spine fracture repair (n=21), and other (n=22). Multivariable logistic regression was used to identify independent predictors of failure of DS requiring MUA and LOA.

Results:
A total of 57 patients with flexion deficits showed median improvement of 30 degrees in flexion (95% confidence interval, 0-90 degrees; P<0.001), and 51 patients with extension deficits showed median improvement of 7 degrees in extension (95% confidence interval, 0-60 degrees; P<0.001). DS was associated with ROM improvement in 84% and avoided the need for surgery in 58% of all 74 patients included in the study. Multivariate analysis of the ACL with meniscus repair subgroup revealed that each 1-month delay in DS treatment was associated with a 5-fold increased risk of undergoing a LOA (P=0.007). Thirty-six (63%) patients with flexion deficit avoided need for surgery, whereas 26 (51%) patients with extension deficits avoided surgery.

Conclusions:
Our data suggest that DS is an effective method to increase knee ROM and reduce the need for subsequent MUA/LOA in the pediatric and adolescent patient with arthrofibrosis after an index knee surgery.

Level of Evidence:
Level IV—retrospective case series.
Body Image and Quality of Life and Brace Wear Adherence in Females With Adolescent Idiopathic Scoliosis
Authors: Schwieger Traci , Campo Shelly , Weinstein Stuart L. , Dolan Lori A. , Ashida Sato , Steuber Keli R. 
Published: February 2016

Background:
Clinical evidence regarding the ability of braces to decrease the risk of curve progression to surgical threshold in patients with adolescent idiopathic scoliosis (AIS) continues to strengthen. Unfortunately, there is still a great deal of uncertainty regarding the impact of brace wear on psychosocial well-being or the impact of psychological well-being on brace wear adherence. The purpose of this study is to evaluate psychosocial well-being, in particular body image and quality of life (QOL), and brace wear adherence in female AIS patients undergoing brace treatment.

Methods:
The Bracing in Adolescent Idiopathic Scoliosis Trial (BrAIST) was a multicenter, controlled trial using randomized and preference assignments into an observation or brace treatment group. BrAIST patients were skeletally immature adolescents diagnosed with AIS having moderate curve sizes (20 to 40 degrees). Patients in the bracing group were instructed to wear a thoracolumbosacral orthosis, at least 18 h/d. Scores on the Spinal Appearance Questionnaire and the PedsQL4.0 Generic Scales from 167 female BrAIST patients who were randomized to brace treatment (n=58) and patients who chose brace treatment (n=109) were analyzed.

Results:
At baseline and at 12 months, no differences were found between the least-adherent brace wear group (<6 h/d) and most-adherent brace wear group (≥12 h/d) patients in terms of major curve, body image, and QOL. In the most-adherent group, poorer body image scores were significantly correlated with poorer QOL scores at baseline, at 6 months, and at 12 months but not at 18 months. In general, body image scores and QOL scores were not significantly correlated in the least-adherent group. When comparing patients that had a ≥6 degree increase of their major curve between baseline and 12 months to patients that did not, there were no significant differences in body image or QOL scores.

Conclusions:
For females adolescents with AIS, body image and QOL do not have a significant impact on brace wear adherence and are subsequently not significantly impacted by brace wear.

Level of Evidence:
Level II—therapeutic (prospective comparative study).
Femoral Neck Stress Fractures in Children Younger Than 10 Years of Age
Authors: Boyle Matthew J. , Hogue Grant D. , Heyworth Benton E. , Ackerman Kathryn , Quinn Bridget , Yen Yi-Meng 
Published: February 2016

Background:
Femoral neck stress fractures are rare in healthy children, with only 9 cases previously reported. The present article reviews our institutional experience with femoral neck stress fractures in children younger than 10 years of age, to highlight the unique features of this condition.

Methods:
We undertook a retrospective review of clinical records of patients who had been treated at our institution for an idiopathic femoral neck stress fracture between 2000 and 2014. To focus on children rather than adolescents, the World Health Organization’s definition of adolescent as a person between 10 and 19 years of age was used; we thereby limited our analysis to patients younger than 10 years of age.

Results:
The study included 6 patients (3 males, 3 females) treated for an idiopathic femoral neck stress fracture, with a mean age at diagnosis of 7.7 years (range, 5.2 to 8.9 y). All patients presented with a limp, which worsened with activity and had persisted for a mean of 5 weeks (range, 2 to 9 wk). None of the patients had experienced an increase in activity level or sporting volume before symptom onset. On examination, 3 patients experienced pain with terminal hip flexion and 3 patients demonstrated pain-free hip range of motion. Plain radiography demonstrated inferior femoral neck cortical disruption, suggesting a compression-type stress fracture mechanism. The diagnosis was confirmed by cross-sectional imaging in all cases. All patients were initially treated with 6 to 8 weeks of non–weight-bearing followed by 4 to 6 weeks of partial weight-bearing, leading to complete healing in 4 patients. Two patients demonstrated incomplete healing and were managed with spica casting for an additional 6 weeks.

Conclusions:
Our case series illustrates the unique features of this rare condition in children, with a history and examination profile distinct from those of adolescents and adults. Compliance with weight-bearing restrictions is difficult in this population and hip spica casting may be required to permit complete healing.

Level of Evidence:
Level IV—case series.
Phenotypic Variation in Different Lesions of Mycosis Fungoides Biopsied Within a Short Period of Time From the Same Patient
Authors: Kash Natalie , Massone Cesare , Fink-Puches Regina , Cerroni Lorenzo 
Published: February 2016

Abstract:
Phenotypic variants of mycosis fungoides (MF) include mainly the expression of cytotoxic markers by neoplastic cells (either α/β or γ/δ cytotoxic). To manage the patient properly, distinction from other cutaneous cytotoxic natural killer/T-cell lymphomas is paramount. Particularly for cutaneous γ/δ T-cell lymphoma, distinction is often based on clinicopathologic correlation (presence of tumors at first diagnosis as opposed to patches only in MF). The authors report a case of cytotoxic MF characterized by expression of TCRγ in two of three biopsies performed within a time frame of 1 week. The patient presented with patches, plaques, and 1 tumor at the time of first diagnosis; thus, distinction from cutaneous γ/δ T-cell lymphoma was not possible on clinical grounds alone. The diagnosis of MF was established, thanks to the phenotypic variations revealed by the three biopsies, with 1 lacking expression of cytotoxic proteins (TIA-1 and granzyme B) and of TCRγ. This case shows the importance to perform several biopsies in cases of cutaneous lymphoma, as morphologic and phenotypic features are variable and information gathered from a single biopsy may result in a wrong diagnosis.
Epidemiology and Outcome of Acute Kidney Injury According to Pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease and Kidney Disease: Improving Global Outcomes Criteria in Critically Ill Children—A Prospective Study*
Authors: Volpon Leila C. , Sugo Edward K. , Consulin Julio C. , Tavares Tabata L. G. , Aragon Davi C. , Carlotti Ana P. C. P. 
Published: February 2016

Objective:
We aimed to investigate the epidemiology, risk factors, and short- and medium-term outcome of acute kidney injury classified according to pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease, and Kidney Disease: Improving Global Outcomes criteria in critically ill children.

Design:
Prospective observational cohort study.

Setting:
Two eight-bed PICUs of a tertiary-care university hospital.

Patients:
A heterogeneous population of critically ill children.

Interventions:
None.

Measurements and Main Results:
Demographic, clinical, laboratory, and outcome data were collected on all patients admitted to the PICUs from August 2011 to January 2012, with at least 24 hours of PICU stay. Of the 214 consecutive admissions, 160 were analyzed. The prevalence of acute kidney injury according to pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease and Kidney Disease: Improving Global Outcomes criteria was 49.4% vs. 46.2%, respectively. A larger proportion of acute kidney injury episodes was categorized as Kidney Disease: Improving Global Outcomes stage 3 (50%) compared with pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease F (39.2%). Inotropic score greater than 10 was a risk factor for acute kidney injury severity. About 35% of patients with acute kidney injury who survived were discharged from the PICU with an estimated creatinine clearance less than 75 mL/min/1.73 m2 and one persisted with altered renal function 6 months after PICU discharge. Age 12 months old or younger was a risk factor for estimated creatinine clearance less than 75 mL/min/1.73 m2 at PICU discharge. Acute kidney injury and its severity were associated with increased PICU length of stay and longer duration of mechanical ventilation. Eleven patients died; nine had acute kidney injury (p < 0.05). The only risk factor associated with death after multivariate adjustment was Pediatric Risk of Mortality score greater than or equal to 10.

Conclusions:
Acute kidney injury defined by both pediatric Risk, Injury, Failure, Loss, End-Stage Renal Disease and Kidney Disease: Improving Global Outcomes criteria was associated with increased morbidity and mortality, and may lead to long-term renal dysfunction.
Protective Role of BST2 Polymorphisms in Mother-to-Child Transmission of HIV-1 and Adult AIDS Progression
Authors: Kamada Anselmo J. , Bianco Anna M. , Zupin Luisa , Girardelli Martina , Matte Maria C. C. , Medeiros Rúbia Marília de , Almeida Sabrina Esteves de Matos , Rocha Marineide M. , Segat Ludovica , Chies José A. B. , Kuhn Louise , Crovella Sergio 
Published: February 2016

Abstract:
Bone marrow stromal cell antigen-2 (BST-2)/Tetherin is a restriction factor that prevents Human immunodeficiency virus type 1 (HIV-1) release from infected cells and mediates pro-inflammatory cytokine production. This study investigated the risk conferred by single nucleotide polymorphisms (rs919266, rs9192677, and rs9576) at BST-2 coding gene (BST2) in HIV-1 mother-to-child transmission and in disease progression. Initially, 101 HIV-1+ pregnant women and 331 neonates exposed to HIV-1 from Zambia were enrolled. Additional BST2 single nucleotide polymorphism analyses were performed in 2 cohorts with acquired immunodeficiency syndrome (AIDS) progression: an adult Brazilian cohort (37 rapid, 30 chronic and 21 long-term non-progressors) and an Italian pediatric cohort (21 rapid and 67 slow progressors). The rs9576A allele was nominally associated with protection during breastfeeding (P = 0.019) and individuals carrying rs919266 GA showed slower progression to AIDS (P = 0.033). Despite the influence of rs919266 and rs9576 on BST2 expression being still undetermined, a preventive role by BST2 polymorphisms was found during HIV-1 infection.
Incidence of Nephrogenic Systemic Fibrosis Using Gadobenate Dimeglumine in 1423 Patients With Renal Insufficiency Compared With Gadodiamide
Authors: Bruce Richard , Wentland Andrew L. , Haemel Anna K. , Garrett Robert W. , Sadowski Donna R. , Djamali Arjang , Sadowski Elizabeth A. 
Published: February 2016

Objective
The purpose of this study was to assess the incidence of nephrogenic systemic fibrosis (NSF) before and after educational interventions, implementation of a clinical screening process, and change to gadobenate dimeglumine in patients who had an estimated glomerular filtration rate (eGFR) of 30 mL/min per 1.72 m2 or less.

Methods
This is a Health Insurance Portability and Accountability Act compliant, institutional review board exempt study. Two periods were studied—July 2005 to June 2006, during which gadodiamide was utilized as our magnetic resonance (MR) contrast agent, and November 2006 to August 2014, during which gadobenate dimeglumine was used as our MR contrast agent in patients who had an eGFR 30 mL/min per 1.72 m2 or less. In addition to a change in the MR contrast agent, education of our staff physician to the risks of NSF with MR contrast agents and the implementation of a clinical screening process occurred. The rate of NSF before and after the interventions was compared using the χ2 test.

Results
There was a statistically significant difference in the incidence of NSF in patients with an eGFR 30 mL/min per 1.72 m2 or less between the 2 periods: July 2005 to June 2006, 6 of 246 patients were diagnosed with NSF (P < 0.001), versus November 2006 to August 2014, 0 of 1423 patients were diagnosed with NSF.

Conclusions
Our data demonstrates a marked decrease in the incidence of NSF after education of our referring physicians, implementation of clinical screening process, and change to gadobenate dimeglumine from gadodiamide in patients with renal insufficiency. This approach potentially provides an acceptable risk-benefit profile for patients with renal insufficiency that required MR imaging for clinical care.
Neck abscess as the initial manifestation of pharyngeal cancer
Authors: Uhliarova Barbora , Hajtman Andrej 
Published: February 2016

Introduction:
Pharyngeal carcinoma and neck abscesses are not uncommon, but neck infection as the initial presentation of primary head and neck cancer is rare, and these patients risk potential misdiagnosis.

Case presentation:
We report our experience with two patients who had an unusual first presentation of pharyngeal cancer – a deep neck infection and a relapsing abscess of the thyroid gland.

Conclusion:
Our case series demonstrates the need for meticulous physical examination of the head and neck in all patients presenting with neck abscess. It is important to consider malignant tumour as a possible cause of deep neck infection and an abscess of the thyroid gland. Diagnosis and subsequent treatment is delayed if malignancy is not clinically suspected.
Examining ICT application adoption in Australian home-based businesses
Authors: Burgess Stephen , Paguio Rafael 
Published: February 2016

Purpose
– The purpose of this paper is to report on a study that examines an under-researched area, the use of information and communications technologies (ICT) in Australian home-based businesses (HBB).

Design/methodology/approach
– HBB constitute a large part of the economy, yet little is known of how they use ICT to improve their business operations. The study involved a case study comprising interviews with 30 business operators in the Western region of Melbourne, a major Australian city. The findings were analysed using a unique approach to Rogers’ (2003) Diffusion of Innovations, employing the innovation-decision process as a lens for the analysis.

Findings
– The study findings suggest that ICT application adoption in HBB participants is not uniform, with adoption of applications such as e-mail differing from adoption of newer applications, such as social networking. ICT use needs to be considered according to individual ICT applications and explained in the context of particular HBB. The study contributes to studies of innovation adoption, particularly in relation to the use of ICT applications in HBB.

Research limitations/implications
– It should be remembered that this study involved interviews with a broad selection of 30 HBB in the Western region of Melbourne, Australia. The results should be considered in the context of hypothesis generation in regards to HBB rather than hypothesis testing that can occur with larger samples. The authors feel that this study would be representative of the practices of ICT adoption in many such groupings of HBB in cities of major Western countries, but hesitate to claim that similar, specific uses of ICT applications would be matched elsewhere.

Practical implications
– This study has a number of practical implications. The results suggest that researchers should consider adoption of individual ICT applications in HBB. Further, policy makers looking to support the use of ICT by HBB should consider that the HBB in this study had adopted different ICT applications and were at different stages of ICT adoption. This is worth considering when deciding upon policies relating to how to suppzort the HBB sector (such as provision of training support and so forth).

Originality/value
– The paper introduces a unique means to assess the adoption of ICT applications by examining their level of penetration, level of maturity and usefulness to HBB.
Knowledge management capability, customer relationship management, and service quality
Authors: Tseng Shu-Mei 
Published: February 2016

Purpose– Firms survive by exploiting knowledge resources to maintain customer relationships more efficiently and effectively, as well as enhance their service quality. However, whether an enterprise can effectively utilize knowledge resources determines the effectiveness of knowledge management capability (KMC). Hence, the purpose of this paper is to investigate the relationship among KMC, customer relationship management (CRM), and service quality.Design/methodology/approach– In order to explore on KMC, CRM, and service quality, the questionnaire and partial least square (PLS) techniques were used.Findings– The results indicate that KMC has a positive influence on CRM and service quality; and further, that CRM has a positive influence on service quality. This result also reveals constructive suggestions that allow firms to strengthen their KMC and CRM, as well as enhance their service quality.Research limitations/implications– This research applied a purposive sampling method and obtained a slightly inadequate number of respondents. Therefore, it is suggested that future research should apply a random sampling method to collect more responses and increase the generalizability of the findings.Practical implications– This research aims to investigate KMC, CRM, and service quality, as well as establish and verify the patterns of the aforementioned relationships based on how enterprises implement their KMC and CRM to enhance service quality.Originality/value– Although the critical factors for enhancing service quality have been identified in previous studies, few have specifically explored KMC despite the fact that it has a dramatic impact on service quality. To fill this knowledge gap, the present study employed a questionnaire and PLS techniques to explore the relationship among KMC, CRM, and service quality. Comprehending the essentials for enhancing service quality can provide useful management insights into developing effective strategies that allow enterprises to retain customers.
Text mining stackoverflow
Authors: Joorabchi Arash , English Michael , Mahdi Abdulhussain E. 
Published: February 2016

Purpose– The use of social media and in particular community Question Answering (Q & A) websites by learners has increased significantly in recent years. The vast amounts of data posted on these sites provide an opportunity to investigate the topics under discussion and those receiving most attention. The purpose of this paper is to automatically analyse the content of a popular computer programming Q & A website, StackOverflow (SO), determine the exact topics of posted Q & As, and narrow down their categories to help determine subject difficulties of learners. By doing so, the authors have been able to rank identified topics and categories according to their frequencies, and therefore, mark the most asked about subjects and, hence, identify the most difficult and challenging topics commonly faced by learners of computer programming and software development.Design/methodology/approach– In this work the authors have adopted a heuristic research approach combined with a text mining approach to investigate the topics and categories of Q & A posts on the SO website. Almost 186,000 Q & A posts were analysed and their categories refined using Wikipedia as a crowd-sourced classification system. After identifying and counting the occurrence frequency of all the topics and categories, their semantic relationships were established. This data were then presented as a rich graph which could be visualized using graph visualization software such as Gephi.Findings– Reported results and corresponding discussion has given an indication that the insight gained from the process can be further refined and potentially used by instructors, teachers, and educators to pay more attention to and focus on the commonly occurring topics/subjects when designing their course material, delivery, and teaching methods.Research limitations/implications– The proposed approach limits the scope of the analysis to a subset of Q & As which contain one or more links to Wikipedia. Therefore, developing more sophisticated text mining methods capable of analysing a larger portion of available data would improve the accuracy and generalizability of the results.Originality/value– The application of text mining and data analytics technologies in education has created a new interdisciplinary field of research between the education and information sciences, called Educational Data Mining (EDM). The work presented in this paper falls under this field of research; and it is an early attempt at investigating the practical applications of text mining technologies in the area of computer science (CS) education.