bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modeling of Azobenzene-Based Compounds
Authors: Marturano V. , Ambrogi V. , Bandeira N. A. G. , Tylkowski B. , Giamberini M. , Cerruti P. 
Published: October 2017

AbstractAzobenzene is by far the most studied photochromic molecule and its applications range from optical storage to bio-engineering. To exploit the great potential of azobenzene, one must achieve deep understanding of its photochemistry as single molecule in solution AS WELL AS in-chain moiety and pendent group in macromolecular structures. With the advent of computer-aided simulation scientists have been able to match experimental data with computational models. In this chapter, a review on the modeling of azobenzene-containing molecules in different conditions and environments IS provided with a special focus on advanced applications of photo-controllable materials, such as molecular machines and photoactivation of bio-molecules.
Differences in Disinfection Protocols of Raw Material Vials Intended for the Production of Parenteral Nutrition Mixtures
Authors: Humbert Caroline , Cros Cyrille , Bordenave Joelle , Benoit Guy 
Published: October 2017

AbstractBackgroundPreparation of parenteral nutrition (PN) mixtures is performed in a controlled atmosphere area (CAA) under a laminar flow hood. In 2014 and 2015 quality controls have revealed contaminations of PN bags by Bacillus. The different products used to avoid this contamination were Aniosurf premiumMethodsFive protocols have been tested by varying the disinfection step: hydrogen peroxide (H2O2) or sodium hypochlorite (immersion or spray), ethanol (non sporicidal) only by immersion. Prewash and aerosolization steps remained unchanged. For each series, a quantity of 30 vials have been prewashed, then disinfected according to the tested protocol, and finally aerosolized. In order to quantify the effectiveness of disinfection 10 vials were sampled using contact plates at every step of treatment.ResultsMicroorganisms were found after ethanol disinfection (n=4) and aerosolization (n=2). No germs were found when hydrogen peroxide or sodium hypochlorite were used. The atmospheric rates of H2O2 were 0.2 ppm by immersion and 0.8 ppm by spray, these values are below the recommended value level (1 ppm).ConclusionsThis study has validated the use and effectiveness of these disinfecting products. Taking into account the efficiency and ease of use for staff, immersion has been preferred to spray and hydrogen peroxide to sodium hypochlorite.
Die Gouvernementalität widerständiger Alltagspraktiken: eine konzeptionelle Annäherung an Postwachstum, Subjektivierung und alltägliches Gegen-Führen
Authors: Linnemann Kirsten 
Published: October 2017

Zusammenfassung
Der aktuelle Trend zu alternativen Formen der Nahrungsmittelproduktion und Ernährung wird gerahmt von Diskursen über Postwachstum und Nachhaltigkeit, die Alternativen zum hegemonialen Wachstumsparadigma fordern und die gegenwärtige Ordnung zunehmend infrage stellen. Gleichzeitig appellieren sie an das Gewissen einzelner Subjekte und stellen individuelle (Konsum-)Entscheidungen in den größeren Zusammenhang sozial-ökologischer Verantwortungsdiskurse. An dieser Stelle setzt dieser konzeptionelle Aufsatz an: Er argumentiert, dass die Perspektive der Gouvernementalität und das Konzept dercontre-conduite sinnvolle Analysewerkzeuge für dieses komplexe Zusammenspiel aus Verantwortungsdiskursen und Subjektivierungsprozessen bieten und dass auch widerständige Praktiken Machteffekten und Formen der Selbst- und Fremdführung unterliegen.
Incidence, prevalence and seasonal onset variation of Addison’s disease among persons with type 1 diabetes mellitus: nationwide, matched cohort studies
Authors: Chantzichristos Dimitrios , Persson Anders , Eliasson Björn , Miftaraj Mervete , Franzén Stefan , Svensson Ann-Marie , Johannsson Gudmundur 
Published: October 2017

Objectives
We determined the incidence and prevalence of Addison’s disease (AD) among persons with or without type 1 diabetes mellitus (T1DM) in nationwide, matched cohort studies.

Methods
Persons with T1DM were identified from the Swedish National Diabetes Register and each was matched for age, sex, year and county to five controls randomly selected from the general population. Persons with AD were identified from the Swedish National Inpatient Register. Baseline demographics and seasonal onset variation of AD were presented by descriptive statistics. Prevalence and incidence were estimated by proportions and incidence rates, respectively. Times to AD were analyzed using the Cox proportional hazard model.

Results
Between 1998 and 2013, 66 persons with T1DM were diagnosed with AD at a mean age (s.d.) of 36.4 (13.0) years among 36 514 persons with T1DM, while 32 were diagnosed with AD at a mean age of 42.7 (15.2) years among 182 570 controls. The difference in mean age at diagnosis of AD between the groups was 6.3 years (P value = 0.036). The incidence of AD for a person with or without T1DM was therefore 193 and 18 per million person-years, respectively. The adjusted relative risk increase of developing AD in T1DM was 10.8 (95% CI: 7.1–16.5). The highest incidence of AD was observed during February–March and September–October. The prevalence of AD in persons with or without T1DM in December 2012 was 3410 and 208 per million, respectively. The odds ratio for AD in persons with T1DM vs controls was 16.5 (95% CI: 11.1–24.5).

Conclusion
The risk to develop AD among persons with T1DM is more than 10 times higher than in persons without T1DM. Persons with T1DM develop AD at a younger age. The incidence of AD may have a seasonal pattern.
Repression of Middle Sporulation Genes in Saccharomyces cerevisiae by the Sum1-Rfm1-Hst1 Complex Is Maintained by Set1 and H3K4 Methylation
Authors: Jaiswal Deepika , Jezek Meagan , Quijote Jeremiah , Lum Joanna , Choi Grace , Kulkarni Rushmie , Park DoHwan , Green Erin M 
Published: October 2017

Abstract
The conserved yeast histone methyltransferase Set1 targets H3 lysine 4 (H3K4) for mono, di, and trimethylation and is linked to active transcription due to the euchromatic distribution of these methyl marks and the recruitment of Set1 during transcription. However, loss of Set1 results in increased expression of multiple classes of genes, including genes adjacent to telomeres and middle sporulation genes, which are repressed under normal growth conditions because they function in meiotic progression and spore formation. The mechanisms underlying Set1-mediated gene repression are varied, and still unclear in some cases, although repression has been linked to both direct and indirect action of Set1, associated with noncoding transcription, and is often dependent on the H3K4me2 mark. We show that Set1, and particularly the H3K4me2 mark, are implicated in repression of a subset of middle sporulation genes during vegetative growth. In the absence of Set1, there is loss of the DNA-binding transcriptional regulator Sum1 and the associated histone deacetylase Hst1 from chromatin in a locus-specific manner. This is linked to increased H4K5ac at these loci and aberrant middle gene expression. These data indicate that, in addition to DNA sequence, histone modification status also contributes to proper localization of Sum1. Our results also show that the role for Set1 in middle gene expression control diverges as cells receive signals to undergo meiosis. Overall, this work dissects an unexplored role for Set1 in gene-specific repression, and provides important insights into a new mechanism associated with the control of gene expression linked to meiotic differentiation.
Systemrettend oder -destabilisierend? – Das Close-out Netting in der Diskussion
Authors: Kerkemeyer Andreas 
Published: October 2017

Zusammenfassung
Die wichtigste gesetzliche Privilegierung von Derivaten ist die insolvenz- und bankaufsichtsrechtliche Anerkennung des zwischen den Vertragsparteien regelmäßig rahmenvertraglich vereinbarten Close-out Nettings. Dieses ermöglicht es den Parteien von Derivateverträgen im Fall einer (drohenden) Insolvenz des Vertragspartners, alle miteinander geschlossenen Derivatekontrakte zu kündigen, die hieraus resultierenden Forderungen zu verrechnen und von der Gegenpartei sofort den ermittelten Saldo zu fordern. Die rechtliche Anerkennung des Close-out Nettings führt zu einer deutlichen Privilegierung der Gläubiger von Forderungen aus Derivateverträgen gegenüber allen anderen Insolvenzgläubigern. Nachdem der BGH bestimmte Close-out Netting-Klauseln in einer Entscheidung aus dem Jahr 2016 für unwirksam erklärt hat, wurden erst die BaFin und danach der Gesetzgeber tätig, um weiterhin bei allen Finanztermingeschäften das Close-out Netting zu ermöglichen. Diese Entwicklungen nimmt der Beitrag zum Anlass, um das Close-out Netting, das als ein Instrument zur Minderung des systemischen Risikos angesehen wird, zu analysieren und einzuordnen.
Kreditfonds
Authors: Egbers Bernd , Loff Detmar 
Published: October 2017

Zusammenfassung
Seit der Finanzkrise unterliegen konventionelle Kreditgeber einer kapitalintensiveren Bankenregulierung, so dass Kreditfonds als alternative Finanzierungsmöglichkeit für Kreditnehmer und als zusätzliche Anlageform für Investoren Beachtung verdient haben. Zum einen bieten Kreditfonds höhere Flexibilität bei der Gestaltung der Kreditkonditionen und der Transaktionsabwicklung, zum anderen wird es den Investoren ermöglicht, sich an einem durch eine Kapitalverwaltungsgesellschaft professionell verwalteten Portfolio zu beteiligen und typischerweise von einer Risikodiversifizierung zu profitieren.
International Variation in Asthma and Bronchiolitis Guidelines
Authors: Bakel Leigh Anne , Hamid Jemila , Ewusie Joycelyne , Liu Kai , Mussa Joseph , Straus Sharon , Parkin Patricia , Cohen Eyal 
Published: October 2017

BACKGROUND AND OBJECTIVES:
Guideline recommendations for the same clinical condition may vary. The purpose of this study was to determine the degree of agreement among comparable asthma and bronchiolitis treatment recommendations from guidelines.

METHODS:
National and international guidelines were searched by using guideline databases (eg, National Guidelines Clearinghouse: December 16–17, 2014, and January 9, 2015). Guideline recommendations were categorized as (1) recommend, (2) optionally recommend, (3) abstain from recommending, (4) recommend against a treatment, and (5) not addressed by the guideline. The degree of agreement between recommendations was evaluated by using an unweighted and weighted κ score. Pairwise comparisons of the guidelines were evaluated similarly.

RESULTS:
There were 7 guidelines for asthma and 4 guidelines for bronchiolitis. For asthma, there were 166 recommendation topics, with 69 recommendation topics given in ≥2 guidelines. For bronchiolitis, there were 46 recommendation topics, with 21 recommendation topics provided in ≥2 guidelines. The overall κ for asthma was 0.03, both unweighted (95% confidence interval [CI]: −0.01 to 0.07) and weighted (95% CI: −0.01 to 0.10); for bronchiolitis, it was 0.32 unweighted (95% CI: 0.16 to 0.52) and 0.15 weighted (95% CI: −0.01 to 0.5).

CONCLUSIONS:
Less agreement was found in national and international guidelines for asthma than for bronchiolitis. Additional studies are needed to determine if differences are based on patient preferences and values and economic considerations or if other recommendation-level, guideline-level, and condition-level factors are driving these differences.
Shared conservation of America's geological heritage through the National Natural Landmarks Program
Authors: Eggleston Heather , Connors Tim 
Published: October 2017

ABSTRACT
The National Natural Landmarks Program recognizes and encourages the conservation of sites that contain outstanding biological and geological resources. Sites are designated by the Secretary of the Interior for their condition, illustrative character, rarity, diversity, and value to science and education. The National Park Service administers the program and works cooperatively with landowners, managers and partners to promote conservation and appreciation of the nation's natural heritage. There are currently 599 National Natural Landmarks nationwide; with nearly 60% of the sites determined to be significant, in full or in part, because of the geologic resources they contain. Besides fostering the basic program goals of natural heritage recognition and advancing science and education, some National Natural Landmarks are the best remaining examples of a type of feature in the country and sometimes in the world.
Keeping the bay in Glacier Bay National Park: Introducing glacier science to the United States Supreme Court
Authors: Molnia Bruce F. 
Published: October 2017

ABSTRACT
In 2000, seventy-five years after the founding of Glacier Bay National Monument, the United States Supreme Court authorized the State of Alaska to begin legal proceedings related to the ownership of ‘certain marine submerged lands in southeast Alaska’ including the submerged lands contained within what is now Glacier Bay National Park. This narrative presents a summary of how glacier science (glacial geology and glaciology) became an integral part of the argument prepared and presented by the United States Government in response to the State of Alaska's Complaint.
Spectrum of cutaneous manifestations in Wilson’s disease in children in a tertiary care center in South India: a prospective study
Authors: K. J. Karrunya , Bavanandam Sumathi , Dheivamani Nirmala , Reddy Vijayabhaskhar C. , K. Manoharan 
Published: October 2017

Background: Wilson’s disease in children is the most common inherited disorder of copper metabolism in India with varied clinical manifestations secondary to deposition of copper in various organs including skin. Methods: The aim of the study was to study various cutaneous manifestations of Wilson’s disease in south Indian children. A prospective study for a period of one year was conducted at Dermatology and Pediatric Gastroenterology clinic in Government Rajiv Gandhi Hospital, Chennai. Clinical, demographic details, various cutaneous manifestations and results of skin biopsy were analysed. Results: Out of the total 30 children with Wilson’s disease, 93.3% had at least one cutaneous, mucosal, hair or nail findings but not statistically significant between naive and on treatment group. Cutaneous findings, mucosal involvement, hair changes and nail findings were observed in 90%, 36.7%, 46.7% and 60% respectively. Cutaneous findings were more common in liver disease (P value<0.05). Xerosis was the most common cutaneous manifestation seen in 63.3% patients, followed by pigmentation in 36.7% and infection in 30%. KF ring was noted in 53.3%. Icterus and pruritus were seen in one fifth of study children and majority had portal hypertension. Vascular changes like spider nevi, purpura and other features of portal hypertension were noted in 16.6% of study population. Trichomegaly was one of the common hair manifestation found in 9 (30% especially in children already on treatment (p value <0.05). There was no evidence of stainable copper on skin biopsy. Conclusions: The physicians should be aware of various cutaneous manifestations of Wilson’s disease in children.
Is head to chest circumference ratio a better detector of macrosomia in infants of diabetic mothers as compared to birth weight >4000g?
Authors: Jose Priya , Vani Jenifer , Kommu Peter Prasanth Kumar , Kuruvila Satish Korah , Krishnan Lalitha 
Published: October 2017

Background: In populations with a high incidence of low birth weight, a macrosomia index (ratio of head /chest circumference) may better detect infants of diabetic mothers rather than a birth weight of ≥4000g. The objective of this study was to correlate Macrosomia Index ≤1 (MI) with maternal HbA1c at delivery.Methods: Prospective cross-sectional study in a Medical College Hospital in South India from November 2012 to March 2014. Study subjects were 715 term consecutive, mother/neonate pairs, booked, inborn and singleton deliveries. Birth weight, head and chest circumference of neonates, and maternal HbA1c at delivery were measured. The calculated macrosmia index (MI) was correlated with maternal HbA1c. Pearson correlation and odd’s ratio were calculated.Results: Of 715 mothers, 68.3% (488/715) had HbA1c >5.4% (range 4.2 to 10.5%), although only 32.7% (234/715) were categorized as gestational diabetics in pregnancy. Odds of Macrosomia Index ≤1 in neonates with maternal HbA1c > 5.4% was 7 times (95%CI: 3.2-15.4) as compared to that of neonates of mothers with HbA1c ≤ 5.4 (p<0.001). 13.4% (96/715) of neonates had MI ≤1 but only 1.4% (10/715) had birth weight of ≥4000g.Conclusions: MI ≤1 correlated with an HbA1c of >5.4% at delivery. Hence, in addition to birth weight ≥4000g, MI ≤1 should also be used to detect macrosomia in infants of diabetic mothers.
Study of intra-cranial space occupying lesion in children at tertiary care centre, Ahmedabad, Gujarat, India
Authors: Prajapati Nisha 
Published: October 2017

Background: ICSOL is some common children and leads to morbidity and mortality in the absence of early diagnosis and treatment2. Due to advance in diagnostic technique, the prognosis for children with ICSOL is more hopeful because of the development of newer therapeutic modalities. Objective of present study was to investigate the incidence, etiology, clinical manifestations, cilinico-radiological correlation, evaluate the therapeutic modalities and outcome of patients of ICSOLMethods: This prospective study was done among all 40 confirmed cases of space occupying lesion out of total 935 central nervous system related cases & 64 suspected cases admitted at department of peadiatrics in NHL medical college, Ahmedabad during July 2002 to October 2004.Results: Out of total CNS cases, 64 (6.8%) cases clinically diagnosed as SOLs cases and 40 (62.5%) were confirmed by radiological imaging technique. Study observed >50% cases in 5-9 age group and 57.5% male SOL. Tubeculoma covered highest (45.0%) cases and convulsion, headache, vomiting and altered sensorium were the main sign/symptoms. According to radiological findings, supratentorial SOL seen in 75.0% cases and mortality seen in 7.5% cases.Conclusions: Study observed higher incidence of SOL in the age group of 5 to 9 years. Total CNS cases were about 20.9% out of total admission and incidence of SOL was about 4.28% in total CNS cases. Highest incidence of tuberculoma which was most common etiology observed among both the gender. Study observed clinic-radiological correlation in SOL was about 62.5%. overall mortality in present in SOL was 7.5.
Editorial
Authors: Marchetto Margarida 
Published: October 2017

E & S - Engineering and Science é uma Revista Eletrônica Internacional que possui corpo editorial e revisores de diversas áreas de especializações, para atender as necessidades correlatas a Ciência e a Tecnologia. A Revista está aberta para receber contribuições de pesquisadores da UFMT, dos cursos de graduação e pós graduação e de diferentes locais dentro e fora do País. Na Segunda Edição da Revista foi possível reunir 11 (onze) trabalhos sendo 08 relacionado a engenharias, 01(um) relacionado à Engenharia Civil, 03 (três) relacionados à Engenharia Elétrica, e 03 (três) referem-se a Engenharia Sanitária e Ambiental, Recursos Hídricos e entre os 03 (três) das Ciências Ambientais, 01 refere-se à Estatística Aplicada. Observa-se a importância deste veículo de divulgação para atender os programas de mestrado em Recursos Hídricos e Engenharia, Edificações e Ambiental para divulgação das produções dos pesquisadores da Faculdade de Arquitetura, Engenharia e Tecnologia - FAET e Instituto de Ciências Exatas e da Terra – ICET da UFMT.
Uma Contribuição à Recuperação Emergencial de Pavimentos Flexíveis. Estudo de Caso: BR-163 na Travessia Urbana de Jaciara/MT
Authors: Barella Andressa Mokan , Miranda Luiz Miguel de 
Published: October 2017

O trabalho trata da descrição de um método de aplicação das medidas necessárias para prover projetos de recuperação emergencial de pavimentos, tendo como estudo de caso a BR-163, no trecho da travessia urbana da cidade de Jaciara/MT. O método inclui o levantamento visual contínuo, estudos e contagens de tráfego, avaliação das condições do revestimento da pista de rolamento e dos acostamentos, avaliação expedita do pavimento, com base nos índices Somatório de Defeitos Ponderados (SDP), Índice de Degradação do Pavimento (IDP), Nota de Desempenho do Pavimento (NDP) e Índice de Gravidade Emergencial Expedido (IGEE). Após o tratamento dos resultados, verificou-se que em um subtrecho não há a necessidade de intervenções, devido a um recapeamento executado poucos dias antes do levantamento. Em dois segmentos indica-se fresagem do pavimento e recapeamento com concreto betuminoso usinado à quente (CBUQ), e nos segmentos mais degradados o mesmo procedimento complementado com camada de bloqueio antirreflexão de trincas de tratamento superficial duplo.
História da institucionalização da educação infantil: dos espaços de assistência à obrigatoriedade de ensino (1875-2013)
Authors: Filipim Priscila Viviane de Souza , Rossi Ednéia Regina , Rodrigues Elaine 
Published: October 2017

Neste artigo, a intenção é abordar a história da institucionalização da educação infantil no Brasil, tendo como fonte a legislação brasileira e pesquisas realizadas sobre o tema. As nomenclaturas existentes para as instituições deste nível encerram, em si, conceitos e finalidades distintos e estão atreladas aos contextos históricos de seus países de origem. Ao longo da idade moderna, criou-se um conceito de infância e o entendimento da importância de estímulos para o seu desenvolvimento. Essa mentalidade impulsiona iniciativas de criação de espaços exclusivos de formação e a compreensão do direito da criança à educação. Essa visão é contemplada no texto da Constituição Federal do Brasil de 1988 e no Estatuto da criança e do adolescente – Lei nº 8.069/90. Assim, como direito, a Lei de Diretrizes e Bases da Educação Nacional (LDBEN, nº 9.394/96) insere a educação infantil no sistema de educação nacional, sendo a obrigatoriedade de parte deste nível instituída pela Lei 12.796 de 2013. Correlatas a essas mudanças, as Diretrizes Curriculares Nacionais para a Educação Infantil propagam a ideia educacional de indissociabilidade do cuidar, do educar e do brincar.