bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bereavement outcomes: A quantitative survey identifying risk factors in informal carers bereaved through cancer
Authors: Roulston Audrey , Campbell Anne , Cairnduff Victoria , Fitzpatrick Deirdre , Donnelly Conan , Gavin Anna 
Published: May 2016

Background: Enabling patients to die in their preferred place is important but achieving preferred place of death may increase the informal carer’s risk into bereavement. Aim: To determine risk factors of family carers bereaved through cancer in Northern Ireland. Design: These results form part of a larger QUALYCARE-NI study which used postal questionnaires to capture quantitative data on carer’s bereavement scores using the Texas Revised Inventory of Grief. Setting/participants: Participants were individuals who registered the death of a person between 1 December 2011 and 31 May 2012; where cancer (defined by ICD10 codes C00-D48) was the primary cause; where the deceased was over 18 years of age and death occurred at home, hospice, nursing home or hospital in Northern Ireland. Participants were approached in confidence by the Demography and Methodology Branch of the Northern Ireland Statistics and Research Agency. Those wishing to decline participation were invited to return the reply slip. Non-responders received a second questionnaire 6 weeks after initial invitation. Results indicated that risk factors positively influencing bereavement outcomes included patients having no preference for place of death and carers remaining in employment pre- or post-bereavement. In contrast, patients dying in hospital, carers stopping work, being of lower socio-economic status and close kinship to the deceased negatively affected bereavement scores. Family carers should be adequately supported to continue in employment; priority should be given to assessing the financial needs of families from lower socio-economic areas; and bereavement support should focus on close relatives of the deceased.
The influence of a telehealth project on healthcare professional recruitment and retention in remote areas in Mali: A longitudinal study
Authors: Mbemba Gisèle Irène Claudine , Bagayoko Cheick Oumar , Gagnon Marie-Pierre , Hamelin-Brabant Louise , Simonyan David A 
Published: May 2016

Objectives: The telehealth project EQUI-ResHuS (in French, Les TIC pour un accès Équitable aux Ressources Humaines en Santé) aimed to contribute to more equitable access to care and support practice in remote regions in Mali. This study explored the evolution of perceptions concerning telehealth among healthcare professionals in the four district health centres that participated in the EQUI-ResHus project and identified variables influencing their perceptions of telehealth impact on recruitment and retention of health professionals. Methods: One year after a first survey (T1), a second data collection (T2) was carried out among healthcare professionals using a 91-item questionnaire. Questions assessing telehealth use and perceptions and perceived impact on recruitment and retention of healthcare professionals were rated on a 5-point Likert scale. A total of 10 independent variables were considered for the analyses. A Wilcoxon signed-rank test was performed to detect differences between T1 and T2, and a bivariate linear regression model for repeated measures was carried out to assess the impact of independent variables on dependent variables. Results: There were no noticeable changes in perceptions related to telehealth influence on recruitment and retention. Only access to information and communication technology significantly differed between T1 and T2 according the Wilcoxon rank test (p = 0.001). Perceived influence of telehealth on recruitment and retention was mostly explained by attitude towards telehealth, perceived effect on recruitment and retention and barriers to recruitment and retention. Conclusion: Based on our results, telehealth was perceived as having a positive influence but mostly indirect influence on healthcare professional recruitment and retention. Also, there were no major changes after 1 year of telehealth use.
Abnormalities of follicular helper T-cell number and function in Wiskott-Aldrich syndrome
Authors: Zhang Xuan , Dai Rongxin , Li Wenyan , Zhao Hongyi , Zhang Yongjie , Zhou Lina , Du Hongqiang , Luo Guangjin , Wu Junfeng , Niu Linlin , An Yunfei , Zhang Zhiyong , Ding Yuan , Song Wenxia , Liu Chaohong , Zhao Xiaodong 
Published: May 2016

Abstract
Wiskott-Aldrich syndrome protein (WASp) is a hematopoietic-specific regulator of actin nucleation. Wiskott-Aldrich syndrome (WAS) patients show immunodeficiencies, most of which have been attributed to defective T-cell functions. T follicular helper (Tfh) cells are the major CD4+ T-cell subset with specialized B-cell helper capabilities. Aberrant Tfh cells activities are involved in immunopathologies such as autoimmunity, immunodeficiencies, and lymphomas. We found that in WAS patients, the number of circulating Tfh cells was significantly reduced due to reduced proliferation and increased apoptosis, and Tfh cells were Th2 and Th17 polarized. The expression of inducible costimulator (ICOS) in circulating Tfh cells was higher in WAS patients than in controls. BCL6 expression was decreased in total CD4+ T and Tfh cells of WAS patients. Mirroring the results in patients, the frequency of Tfh cells in WAS knockout (KO) mice was decreased, as was the frequency of BCL6+ Tfh cells, but the frequency of ICOS+ Tfh cells was increased. Using WAS chimera mice, we found that the number of ICOS+ Tfh cells was decreased in WAS chimera mice, indicating that the increase in ICOS+ Tfh cells in WAS KO mice was cell extrinsic. The data from in vivo CD4+ naive T-cell adoptive transfer mice as well as in vitro coculture of naive B and Tfh cells showed that the defective function of WASp-deficient Tfh cells was T-cell intrinsic. Consistent findings in both WAS patients and WAS KO mice suggested an essential role for WASp in the development and memory response of Tfh cells and that WASp deficiency causes a deficient differentiation defect in Tfh cells by downregulating the transcription level of BCL6.
Open, non-comparative, multi-centre post clinical study of the performance and safety of a gelling fibre wound dressing on diabetic foot ulcers
Authors: Chadwick P. , McCardle J. 
Published: May 2016

Objective: To evaluate the performance and safety of Exufiber, a gelling fibre wound dressing incorporating Hydrolock technology, in the management of highly exuding diabetic foot ulcers (DFUs). Method: The study was conducted over a 12 week period involving a total of 21 patients with DFUs. A number of parameters were measured to monitor the change in condition of the peri-wound skin from baseline assessments. The evaluation of dressing-related pain was measured using a 100mm visual analogue scale (VAS). Wound status (measured by changes in wound size and healing phase) was recorded. Clinician/patient opinions of the test product and technical performance (measured by the presence of dressing residue following removal and handling of wound exudate) were also recorded. Results: The number of patients with healthy/intact peri-wound skin increased from baseline to the final visit. There was also a steady decrease in wound exudate volume throughout the study. Pain levels were very low throughout the investigation period, bearing in mind issues with neuropathy. A gradual decline in all wound size parameters from baseline to the final visit was noted; there was a statistically significant reduction in both wound area (cm2), p=0.0094, and wound volume (cc), p=0.0056, from baseline to the final visit. Throughout the study, a small decline in the mean percentage of granulation tissue within the wound paralleled a gradual increase in the mean percentage of epithelialisation tissue, while the percentage of non-viable tissue remained very low. The primary endpoints of product performance and safety were measured by the changes from baseline in the condition of the peri-wound skin. Results showed that the number of patients with healthy/intact peri-wound skin increased from baseline to the final visit, increasing from 6 patients (28.6%) at baseline to 14 patients (66.7%) at the final visit. There were no occurrences of product degradation on the skin and no reported adverse events (AE)/adverse device effects (ADE) during the course of the study that were judged to be related to the investigational product. Conclusion: This study has demonstrated the capacity for the test dressing to minimise damage to the peri-wound skin and dressing-associated pain. Despite the majority of wounds remaining unhealed at the final visit, improvements were noted in terms of tissue type and a significant reduction in wound area and volume. The technical performance of the dressing was demonstrated by an ability to absorb and retain exudate. Product safety was also demonstrated by an increase in the number of patients with healthy/intact peri-wound skin and the lack of identified product-related AE/ADEs. Declaration of interest: The study was supported by an unrestricted educational grant from Mölnlycke Health Care.
Method Comparison of Model Based Tomography and Grid Based Tomography to refine interval velocity
Authors: Nugroho Yuninggar Dwi , S Sudarmaji 
Published: May 2016

<span>The input data for pre stack time migration and pre stack depth migration is velocity model. <span>The exact velocity model can provide maximum result in seismic section. The best seismic <span>section can minimize possibility of errors during interpretation. Model based and grid based <span>tomography are used to refine the interval velocity model. The interval velocity will be used as <span>input in the pre stack depth migration. Initial interval velocity is obtained from RMS velocity<br /><span>using Dix formula. This velocity will be refined by global depth tomography method. The <span>global depth tomography method is divided into model based and grid based tomography. <span>Velocity analysis is performed along the horizon (depth model). Residual depth move out is <span>obtained from picking velocity. It is used as input in tomography method. The flat gather is <span>obtained at tenth iteration. The interval velocity that is obtained from tenth iteration has the <span>small errors. Tomography method can provide maximum result on velocity refinement. That is <span>shown by the result that the pre stack depth migration is much better than using initial interval <span>velocity. The pull up effect can be corrected by tomography method.</span></span></span></span></span></span></span></span></span></span></span></span><br /></span>
Kontaminasi senyawa poliklorobifenil (PCB) pada kerang hijau, Perna viridis dari Teluk Jakarta
Authors: Edward Edward 
Published: May 2016

The objective of this research was to examine the contamination level of polychlorinated biphenyl compound in green mussels. Green mussels samples were collected in Jakarta Bay in March 2013. Polychlorinated biphenyl level were quantified by gas chromatography HP 5880 series II completely with Electron Capture Detector (ECD). The levels of polychlorinatedbiphenyl in small size mussels was 0.846 ppb, in medium size mussels was 0.854 ppb, and in biger size mussels was 2.018 ppb. These levels were lowercompared to the safe threshold value for seafood which in 2,000 ppb. Therefore the green mussels from Jakarta Bay is safe to consumpt. Penelitian ini bertujuan untuk menentukan tingkat kontaminasi senyawa polikloro bifenil dalam kerang hijau. Contoh kerang hijau dikumpulkan di Teluk Jakarta pada bulan Maret 2013. Kadar polikloro bifenil diukur dengan alat kromatografi gas HP 5880 series II, yang dilengkapi dengan detektor penangkap elektron (ECD). Kadar polikloro bifenil dalam kerang hijau ukuran kecil adalah 0,846 ppb, kerang ukuran sedang adalah 0,854 ppb dan kerang ukuran besar adalah 2,018 ppb. Kadar ini masih rendah bila dibandingkan dengan nilai ambang batas aman untuk makanan hasil laut yakni 2000 ppb. Hasil penelitian ini diharapkan dapat memberikan informasi kepada masyarakat apakah kerang hijau di Teluk Jakarta ini masih aman untuk dikonsumsi.
Comparison of the Predictive Value of GlycA and Other Biomarkers of Inflammation for Total Death, Incident Cardiovascular Events, Noncardiovascular and Noncancer Inflammatory-Related Events, and Total Cancer Events
Authors: Duprez Daniel A , Otvos James , Sanchez Otto A , Mackey Rachel H , Tracy Russell , Jacobs David R 
Published: May 2016

Abstract

BACKGROUND
GlycA is a biomarker that reflects integrated concentrations and glycosylation states of several acute-phase proteins. We studied the association of GlycA and inflammatory biomarkers with future death and disease.

METHODS
A total of 6523 men and women in the Multi-Ethnic Study of Atherosclerosis who were free of overt cardiovascular disease (CVD) and in generally good health had a baseline blood sample taken. We assayed high-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and d-dimer. A spectral deconvolution algorithm was used to quantify GlycA signal amplitudes from automated nuclear magnetic resonance (NMR) LipoProfile® test spectra. Median follow-up was 12.1 years. Among 4 primary outcomes, CVD events were adjudicated, death was by death certificate, and chronic inflammatory-related severe hospitalization and death (ChrIRD) and total cancer were classified using International Classification of Diseases (ICD) codes. We used Poisson regression to study baseline GlycA, hsCRP, IL-6, and d-dimer in relation to total death, CVD, ChrIRD, and total cancer.

RESULTS
Relative risk per SD of GlycA, IL-6, and d-dimer for total death (n = 915); for total CVD (n = 922); and for ChrIRD (n = 1324) ranged from 1.05 to 1.20, independently of covariates. In contrast, prediction from hsCRP was statistically explained by adjustment for other inflammatory variables. Only GlycA was predictive for total cancer (n = 663). Women had 7% higher values of all inflammatory biomarkers than men and had a significantly lower GlycA prediction coefficient than men in predicting total cancer.

CONCLUSIONS
The composite biomarker GlycA derived from NMR is associated with risk for total death, CVD, ChrIRD, and total cancer after adjustment for hsCRP, IL-6, and d-dimer. IL-6 and d-dimer contribute information independently of GlycA.
PEDAGOGIA HISTORICO-CRITICA E METODOLOGIA DE ENSINO CRITICO-SUPERADORA DA EDUCAÇÃO FÍSICA: NEXOS E DETERMINAÇOES
Authors: Taffarel Celi Zulke 
Published: May 2016

O presente texto apresenta reflexões e contribuições a partir das aproximações entre a Teoria Pedagógica Histórico-Critica e o trato com o conhecimento da Cultura Corporal mediada pela metodologia específica de ensino da Educação Física denominada Crítico-Superadora. Parte da consideração da Cultura Corporal como categoria teórica que nos permite apreender no pensamento, compreender, explicar cientificamente o real concreto, sendo, portanto, um objeto de estudo e ensino que se compõe de outros objetos de estudo e ensino – Esporte, Jogo, Dança, Ginástica, Luta, entre outros –, o que nos permite, uma vez apreendida sua estrutura lógico-histórica, propor, em especial no sistema educacional, como tratar o conhecimento específico da cultura corporal na escola e nas aulas de Educação Física, visando elevar o pensamento teórico dos estudantes, na perspectiva da emancipação humana e da omnilateralidade. http://dx.doi.org/10.14572/nuances.v27i1.3962
Conversão catalítica de alquilaromáticos sobre catalisadores micro-mesoporosos em reator gás-sólido de leito fixo visando à obtenção de olefinas
Authors: Rêgo Ana Carolina Barbosa , Nascimento Éricles Vale , Santos Nascimento Tyciane Geovana , Garrido Pedrosa Anne Michelle , Souza Marcelo José Barros 
Published: May 2016

O objetivo deste trabalho foi estudar a síntese e caracterização de catalisadores micro-mesoporosos e sua aplicação na reação modelo de conversão de isopropilbenzeno em microreator catalítico de leito fixo com fluxo contínuo visando à obtenção de olefinas. Catalisadores micro-mesoporosos do tipo HZSM-5/MCM-41e La/HZSM-5/MCM-41foram sintetizados através do método mecanosíntese e impregnação por via úmida, respectivamente. Os catalisadores foram caracterizados por difração de raios-X e através de reações com molécula modelo. Isopropilbenzeno (cumeno) foi usado como molécula modelo e a conversão em olefinas foi avaliada através da formação de propeno. Os difratogramas de raios-X indicaram que os catalisadores sintetizados apresentam os picos característicos da estrutura microporosa (zeólita ZSM-5) e a estrutura mesoporosa (MCM-41). Para os catalisadores contendo lantânio, picos devido à presença de óxido de lantânio também foram identificados. Os resultados indicaram que o catalisador compósito La/HZSM-5/MCM-41 foi o mais promissor na conversão do cumeno e produção de propeno.
Avaliação da estabilidade do biodiesel produzido a partir da moringa oleifera lam
Authors: Andrade Livia Caroline Tavares de , França Fernanda Rocha Morais , Ramos André Luis Dantas , Silva Gabriel Francisco da 
Published: May 2016

Os processos oxidativos ocorrem devido às temperaturas elevadas e à presença de ácidos graxos insaturados, com isso, torna-se um desafio a produção de biodiesel de qualidade. Neste sentido, o presente trabalho apresenta parâmetros indicativos da influência antioxidante do biodiesel obtido a partir da Moringa oleifera Lam em diferentes percentuais em biodiesel de soja. As amostras foram caracterizadas através de análises físico-químicas e mediante o estudo oxidativo, através do método Rancimat. As amostras de biodiesel de soja foram aditivadas com o antioxidante nas concentrações de 100, 500, 1000, 2000, 3000, 4000 e 5000 ppm. Todas as amostras foram analisadas no tempo zero. Os resultados obtidos, mostraram que o tempo de estabilidade oxidativa ultrapassou o limite estabelecido pela ANP (mínimo de 8horas) somente a partir da concentração de 2000 ppm e revelaram que quanto maior a concentração de antioxidante utilizada, maior é a estabilidade oxidativa.
Best possible rates of distribution of dense lattice orbits in homogeneous spaces
Authors: Ghosh Anish , Gorodnik Alexander , Nevo Amos 
Published: May 2016

Abstract
This paper establishes upper and lower bounds on the speed of approximation in a wide range of natural Diophantine approximation problems. The upper and lower bounds coincide in many cases, giving rise to optimal results in Diophantine approximation which were inaccessible previously. Our approach proceeds by establishing, more generally, upper and lower bounds for the rate of distribution of dense orbits of a lattice subgroup Γ in a connected Lie (or algebraic) group G, acting on suitable homogeneous spaces G/H. The upper bound is derived using a quantitative duality principle for homogeneous spaces, reducing it to a rate of convergence in the mean ergodic theorem for a family of averaging operators supported on H and acting on G/Γ. In particular, the quality of the upper bound on the rate of distribution we obtain is determined explicitly by the spectrum of H in the automorphic representation on

L
2

L^{2}

(Γ

∖

\setminus

G). We show that the rate is best possible when the representation in question is tempered, and show that the latter condition holds in a wide range of examples.
Products of vector valued Eisenstein series
Authors: Westerholt-Raum Martin 
Published: May 2016

AbstractWe prove that products of at most two vector valued Eisenstein series that originate in level 1 span all spaces of cusp forms for congruence subgroups. This can be viewed as an analogue in the level aspect to a result that goes back to Rankin, and Kohnen and Zagier, which focuses on the weight aspect. The main feature of the proof are vector valued Hecke operators. We recover several classical constructions from them, including classical Hecke operators, Atkin–Lehner involutions, and oldforms. As a corollary to our main theorem, we obtain a vanishing condition for modular forms reminiscent of period relations deduced by Kohnen and Zagier in the context their previously mentioned result.
French and Spanish colonial policy in North Africa: revisiting the Kabyle and Berber myth
Authors: Tilmatine Mohand 
Published: May 2016

AbstractThe French colonial presence in North Africa gave rise to a view that was founded on attributing certain – supposedly distinctive – qualities to the Kabyle people (Algeria) and the Berber people in general (Algeria and Morocco). This became known as “the Kabyle (or Berber) myth” and was propagated both by North African nationalists and by the academic world in order to validate their accusations against the colonial powers of practicing a “divide and conquer” policy. What’s more, from the outset, the French and Spanish colonial governments, by empowering Arabic as an imperial and dominant language to the detriment of the peripheral and low prestige Berber languages, greatly contributed to the widespread acceptance of a further myth, i. e., North Africa was “Arab and Muslim”. These myths then became a key argument used by the post-colonial governments to deny the distinctiveness of the Kabyle people, and Berbers in general, hence justifying rejecting their demands for linguistic and cultural recognition. In recent years, however, the Berber people have reacted to these myths; we have witnessed the birth of a resistance movement, the uprising in Algeria (Kabylie) and the development of cultural pride and identity. Surprisingly, these events have caused us to reflect anew on the Berber myths of the colonial period.
Cannabis Regulation in Uruguay: An Innovative Law Facing Major Challenges
Authors: Walsh John , Ramsey Geoff 
Published: May 2016

Abstract
Uruguay, the first country to enact legislation to legalize and regulate every level of the market for cannabis, will be an important example globally for jurisdictions contemplating whether and how to liberalize drug policies. A combination of political leadership by former President José “Pepe” Mujica and public unease over rising criminality led Uruguay to pursue reforms to place the cannabis market under legal authority of the state, rather than in the hands of illegal groups. The new law, approved in December 2013, encompasses medical as well as adult use, or “recreational cannabis” for which it creates three distinct sources of legal access: home growing, social clubs, and commercial sales through pharmacies. While most Uruguayans remain skeptical of the new cannabis law, the “Broad Front” coalition responsible for passing the law in 2013 renewed its congressional majorities and retained the presidency in the country’s 2014 elections. The current government of President Tabaré Vazquez has stated its commitment to fully implementing the law, but is moving ahead cautiously, mindful of ongoing domestic and international criticisms. While the International Narcotics Control Board (INCB) has castigated Uruguay for violating its international drug treaty obligations, Uruguay has argued that the country’s human rights obligations under international law take priority over drug control treaty requirements. Given the unprecedented nature of Uruguay’s new cannabis regime, successful implementation will require rigorous monitoring and evaluation and the flexibility to make revisions as problems emerge. Rigorous evaluation of Uruguay’s pioneering reforms can also provide important insights and knowledge for other jurisdictions that may wish to consider comparable regulatory approaches.
Crystal structure of (2-(2-chlorophenyl)-5-methyl-1,3-dioxan-5-yl)methanol, C12H15ClO3
Authors: Li Zhong-Yan , Yuan Lin , Zhang Min , Yuan Xian-You 
Published: May 2016

Abstract
C12H15ClO3, monoclinic, P21/c (no. 14), a = 10.0231(14) Å, b = 10.7318(16) Å, c = 11.2419(17) Å, β = 106.637(7)°, V = 1158.6(3) Å3, Z = 4, R
gt
(F) = 0.0493, wR
ref
(F
2
) = 0.1879, T = 296(2) K.