bluuebunny/crossref_metadata_2025_split huggingface dataset:
Generating real‐world evidence on diabetes technology using the CareLink Personal data management system
Authors: van den Heuvel Tim , Castañeda Javier , Arrieta Arcelia , Voelker Benedikt , Cohen Ohad , Liu Margaret , Diaz Garelli Franck , Shin John 
Published: September 2024

AbstractAimTo establish trust in real‐world evidence (RWE) derived from CareLink Personal (CP), Medtronic's data management system for MiniMed system users, we show that this database and its analyses strictly adhere to the principles of RWE.MethodsThe methodology is applicable to all MiniMed iterations. We described every step from raw data to predefined outcomes. In addition, we showed CP's fitness‐for‐research by the below metrics (using last year's MiniMed 780G system data as a case study): representative population, relevant endpoints, appropriate granularity, high data completeness, high data representativity and consistency in results.ResultsThe process from raw data to outcomes has been validated, and metrics/logics adhere to established definitions. Over 95% of users have a CP account; with 96% providing consent, this allows the use of >91% of the census population. There is no rationale for an over‐representation of a specific phenotype among users not included. CP includes >50 endpoints, including ‘International Consensus on Time in Range’ based metrics. Data are recorded at 5‐min intervals (maximum 288 per day), and on average there were 263 data points per person per day. Ninety‐nine per cent of uploads were automated. For the last year, only 1 in 6 users had a data gap >1 day, and 1 in 50 had a gap >1 week. The time in range from in‐silico studies was similar to that of real‐world studies from different geographies and with ever growing populations.ConclusionRWE from CP adheres to the principles of RWE and can serve as robust evidence on the performance and safety of MiniMed systems.
Hopelessness for family members of individuals with borderline personality disorder
Authors: Joyce Mary , Kells Mary , Boylan Emily , Corcoran Paul , Power Bláthín , Wall Stephanie , Flynn Daniel 
Published: September 2024

AbstractFamily members and loved ones of individuals with Borderline Personality Disorder (BPD) can experience high levels of distress. Types of distress reported by family members include burden, grief, depression, guilt, and powerlessness. Hopelessness is a construct that has received little attention despite its potential relevance for this group. This study sought to examine, and assess potential change in, hopelessness among individuals attending a 12‐week Family Connections (FC) program. Participants were 75 family members, 29 men and 46 women. Most participants were parents (n = 43; 57%). Data were collected at four time‐points and outcomes included hopelessness, burden, and grief. The majority of participants (82%) reported scores within the ‘minimal’ or ‘mild’ ranges of hopelessness before the FC program. A greater proportion of participants in the 60–70 year age group reported scores in the ‘moderate/severe’ category when compared with younger age groups. The mean hopelessness score for all participants before FC was 4.61 which is considered mild. There was no significant difference in hopelessness scores after program completion. Although mean scores increased at both 3‐month and 12‐month follow‐ups, they continued to remain in the ‘mild’ category. Hopelessness scores in the current study are similar to those reported in previous studies, although no significant change was found after FC completion. Concepts of personal vs. situational hopelessness should be considered, as well as the relevance of assessing personal hopelessness for this participant group. Further research is needed to determine the relationship between family member hopelessness and index client wellbeing.
Methane fluxes in tidal marshes of the conterminous United States
Authors: Arias‐Ortiz Ariane , Wolfe Jaxine , Bridgham Scott D. , Knox Sara , McNicol Gavin , Needelman Brian A. , Shahan Julie , Stuart‐Haëntjens Ellen J. , Windham‐Myers Lisamarie , Oikawa Patty Y. , Baldocchi Dennis D. , Caplan Joshua S. , Capooci Margaret , Czapla Kenneth M. , Derby R. Kyle , Diefenderfer Heida L. , Forbrich Inke , Groseclose Gina , Keller Jason K. , Kelley Cheryl , Keshta Amr E. , Kleiner Helena S. , Krauss Ken W. , Lane Robert R. , Mack Sarah , Moseman‐Valtierra Serena , Mozdzer Thomas J. , Mueller Peter , Neubauer Scott C. , Noyce Genevieve , Schäfer Karina V. R. , Sanders‐DeMott Rebecca , Schutte Charles A. , Vargas Rodrigo , Weston Nathaniel B. , Wilson Benjamin , Megonigal J. Patrick , Holmquist James R. 
Published: September 2024

AbstractMethane (CH4) is a potent greenhouse gas (GHG) with atmospheric concentrations that have nearly tripled since pre‐industrial times. Wetlands account for a large share of global CH4 emissions, yet the magnitude and factors controlling CH4 fluxes in tidal wetlands remain uncertain. We synthesized CH4 flux data from 100 chamber and 9 eddy covariance (EC) sites across tidal marshes in the conterminous United States to assess controlling factors and improve predictions of CH4 emissions. This effort included creating an open‐source database of chamber‐based GHG fluxes (https://doi.org/10.25573/serc.14227085). Annual fluxes across chamber and EC sites averaged 26 ± 53 g CH4 m−2 year−1, with a median of 3.9 g CH4 m−2 year−1, and only 25% of sites exceeding 18 g CH4 m−2 year−1. The highest fluxes were observed at fresh‐oligohaline sites with daily maximum temperature normals (MATmax) above 25.6°C. These were followed by frequently inundated low and mid‐fresh‐oligohaline marshes with MATmax ≤25.6°C, and mesohaline sites with MATmax >19°C. Quantile regressions of paired chamber CH4 flux and porewater biogeochemistry revealed that the 90th percentile of fluxes fell below 5 ± 3 nmol m−2 s−1 at sulfate concentrations >4.7 ± 0.6 mM, porewater salinity >21 ± 2 psu, or surface water salinity >15 ± 3 psu. Across sites, salinity was the dominant predictor of annual CH4 fluxes, while within sites, temperature, gross primary productivity (GPP), and tidal height controlled variability at diel and seasonal scales. At the diel scale, GPP preceded temperature in importance for predicting CH4 flux changes, while the opposite was observed at the seasonal scale. Water levels influenced the timing and pathway of diel CH4 fluxes, with pulsed releases of stored CH4 at low to rising tide. This study provides data and methods to improve tidal marsh CH4 emission estimates, support blue carbon assessments, and refine national and global GHG inventories.
Identifying mesonephric‐like adenocarcinoma of the endometrium by combining SOX17 and PAX8 immunohistochemistry
Authors: Tahir Maryam , Xing Deyin , Ding Qingqing , Wang Yihong , Singh Kamaljeet , Suarez Adrian A , Parwani Anil , Li Zaibo 
Published: September 2024

AimsMesonephric‐like adenocarcinoma (MLA) of the endometrium or ovary is a rare but distinct endometrial carcinoma which has a combination of characteristic morphological, immunohistochemical (IHC) and molecular features. SOX17 has been recently identified as a highly sensitive and specific marker for endometrial and ovarian carcinomas. In this study, we aimed to investigate SOX17 expression in MLA together with other IHCs to differentiate MLAs from other endometrial carcinomas.MethodsSeventeen previously diagnosed endometrial/ovarian MLAs were collected, and multiple IHCs were performed. Additionally, we performed SOX17, PAX8 and ER on tissue microarrays (TMAs) composed of 652 endometrial carcinomas from 2012 to 2015 when MLA diagnostic criteria were not established.ResultsAll 17 MLAs showed diffuse strong positive PAX8, negative ER and variable TTF1/GATA3 staining. Notably, all MLAs showed negative (n = 10) or focal weak/moderate (n = 7) staining for SOX17, which is more diffuse and stronger than PAX8 in other endometrial carcinoma subtypes. This finding prompted us to screen TMAs with 652 endometrial carcinomas diagnosed before MLA by an approach of combined SOX17 and PAX8 IHCs, and 14 cases with positive PAX8 but negative/focal weak SOX17 were identified. We further studied the 14 cases by examining morphology and performing additional IHCs (TTF1, GATA3, ER and CD10) and would classify seven (50%) of them as MLAs based on morphological features and positive CD10, TTF1 and/or GATA3 staining.ConclusionOur results suggest that a combination of SOX17 and PAX8 IHCs would aid in diagnosing MLA if the results show strong positive PAX8, but negative SOX17.
The effectiveness of double dorsal dartos flap for urethroplasty coverage in distal hypospadias repair: A single surgeon approach to preventing urethrocutaneous fistula
Authors: Mekki Mongi , Fredj Myriam Ben , Messaoud Marwa , Youssef Sabrine Ben , Salah Radhouane Ben , Toumi Afef , Sfar Sami , Mosbahi Sana , Ksiaa Amine , Belghith Mohsen , Chakroun Sawssen , Sahnoun Lassaad 
Published: September 2024

PurposeThe concept of interposing double dorsal preputial flaps to cover the urethroplasty was introduced in 2005 to reduce the risk of urethrocutaneous fistula (UCF). Our study aims to compare the postoperative outcomes of urethroplasty for distal hypospadias between two groups: one receiving single preputial flap coverage and another receiving double flap coverage.Materials and methodsWe conducted a retrospective analysis study of boys with primary distal hypospadias who underwent surgery by the same experienced surgeon, at our department between 2010 and 2021. The study population was divided into two groups: Group A, which underwent urethroplasty coverage with single dorsal preputial flap, and Group B, which underwent coverage with double flap. Postoperative complications were compared between the two groups.ResultsWe collected 105 cases, comprising 51 in Group A and 54 cases in Group B. The mean age at surgery was 29 months in Group A and 24 months in Group B. Post‐operative follow‐up period ranged from 6 months to 8 years. Functional and cosmetic outcomes were judged excellent in 88.7%. Only 10 boys experienced complications requiring reoperation. UCF occurred in 5 patients from Group A, while no cases were reported in Group B (p = 0.024). Meatal stenosis was identified in three patients in Group A and in two patients in Group B (p = 1). No other complications, such as glans dehiscence or penile torsion, were noted.ConclusionDouble dorsal dartos flap is an effective method for covering the new urethra and can be recommended in the treatment of patients with virgin distal hypospadias.
Smart food‐sharing platforms for social sustainability: a heuristic algorithm approach
Authors: Maleki Vishkaei Behzad , De Giovanni Pietro 
Published: September 2024

AbstractThis study examines how smart food‐sharing platforms (SFSP) can help reduce food waste and suggests a method for using smart contracts to share extra food among different partners effectively. For smart contracts to work automatically and prevent food wastage, artificial intelligence systems can recognize how smart clauses should be executed. This will involve analyzing several factors like the selling price, expiration dates, offers from other partners, transport costs, wholesale price, shelf life, donation rates, and demand rates. The findings indicate that adopting an SFSP is an efficient solution for preemptively adopting redistribution strategies and improving social outcomes through donations as well as achieving positive environmental outcomes through reduced waste. However, we also identify cases in which reducing food waste to achieve social sustainability may negatively impact economic performance.
Research on the status and influencing factors of maternal health literacy among postpartum women in urban villages
Authors: Chen Shanxia , Lin Xiaoli , Wang Minyi , Gu Zhimin , Wang Meiyu , Ji Yuting , Yang Ming 
Published: September 2024

AbstractAimTo comprehensively identify the status and influencing factors on maternal health literacy among postpartum women in Guangzhou urban villages.DesignAn explanatory sequential mixed‐method research was conducted from November 2021 to July 2022.MethodsThe quantitative survey was conducted among postpartum women in Guangzhou urban villages using the convenience sampling principle, and a questionnaire survey was used to reflect the status and influencing factors on maternal health literacy. The qualitative interview conducted purposive sampling based on the survey and semi‐structured interviews with women to supplement the non‐quantifiable influencing factors.ResultsThe quantitative survey showed that the maternal health literacy score of 501 women was 193.84 ± 22.23. The quantitative results suggested that ethnicity, education, income, household registration, delivery mode and social support were important influencing factors (p < .15). The qualitative interviews were conducted with 16 women and revealed three themes and eight sub‐themes, including demographic factors (ethnicity, education, income, occupation and family history), pregnancy factors (delivery mode and pregnancy complications) and social factors (social support), which influenced maternal health literacy through three routes: women's motivation, access and ability in screening health information.ConclusionMaternal health literacy among postpartum women in urban villages needs to be improved, especially critical health literacy. Maternal and infant workers need to guide women to develop appropriate health information concepts and consider the realistic knowledge needs of women in different socio‐cultural and economic backgrounds. They should also construct a comprehensive social support system for women to better improve maternal health literacy.ImpactHighlights the positive benefits of maternal health literacy among postpartum women, as preparation for providing accurate and effective maternal and child health education services.Patient or Public ContributionThe information on maternal health literacy in this study was based on an interview with postpartum women in Guangzhou urban villages during the study period.
Suture‐based techniques versus manual compression for femoral venous haemostasis after electrophysiology procedures
Authors: Mills Mark T. , Calvert Peter , Snowdon Richard , Mahida Saagar , Waktare Johan , Borbas Zoltan , Ashrafi Reza , Todd Derick , Modi Simon , Luther Vishal , Gupta Dhiraj 
Published: September 2024

AbstractBackground and aimsMethods for femoral venous haemostasis following electrophysiology (EP) procedures include manual compression (MC) and suture‐based techniques such as a figure‐of‐eight suture secured with a hand‐tied knot (Fo8HT) or a modified figure‐of‐eight suture secured with a 3‐way stopcock (Fo8MOD). We hypothesised that short‐term bleeding outcomes using the Fo8MOD approach would be superior to MC. We additionally compared outcomes between Fo8MOD and Fo8HT approaches.MethodsWe studied consecutive patients undergoing EP procedures at our institution between March and December 2023. Patients were categorised into three haemostasis groups: MC, Fo8HT and Fo8MOD. Access site complications were classified as major (requiring intervention or blood transfusion, delaying discharge or resulting in death) or minor (bleeding/haematoma requiring additional compression).Results1089 patients were included: MC 718 (65.9%); Fo8HT 105 (9.6%); Fo8MOD 266 (24.4%). Procedures were most commonly for atrial fibrillation (52.4%), atrial flutter (10.9%), and atrioventricular nodal re‐entrant tachycardia (10.1%). In patients receiving periprocedural anticoagulation (865, 79.4%), Fo8MOD associated with fewer complications than MC or Fo8HT (major: MC 2.2%, Fo8HT 6.0%, Fo8MOD 0.8%, p = .01; minor: MC 16.5%, Fo8HT 12.0%, Fo8MOD 7.4%, p = .002). In patients not receiving periprocedural anticoagulation, complications did not differ between haemostasis methods (total major and minor complications 5.8%, p = .729 for between groups rates). On multivariable logistic regression, Fo8MOD was associated with a significantly lower risk of access site complications (OR 0.29 [95% CI 0.17–0.48], p < .001), whilst intraprocedural heparinisation (OR 5.25 [2.88–9.69], p < .001) and larger maximal sheath size (OR 1.06 [1.00–1.11], p = .04) were associated with a higher risk of complications.ConclusionFemoral haemostasis with Fo8MOD associates with fewer access site complications than MC and Fo8HT following EP procedures that need periprocedural anticoagulation.
Factors influencing food‐related quality of life in patients with inflammatory bowel disease: A systematic review
Authors: Zhu Wenli , Zhang Yan , Wang Linda Dong‐Ling , Li Jiajia , Hou Sicong 
Published: September 2024

AbstractBackgroundPeople diagnosed with Inflammatory bowel disease (IBD) often have severe dietary restrictions and avoidance due to the uncertainty of intestinal symptoms. Inadequate dietary intake may increase the risk of malnutrition and result in impaired food‐related quality of life (FRQoL). Few studies investigated factors influencing FRQoL in patients with IBD. This study aimed to synthesize the existing evidence regarding FRQoL among patients with IBD, including the current situation, measurement instruments, and related influencing factors.MethodThe comprehensive literature search was conducted in databases including PubMed, Embase, CINAHL, PsycInfo, Cochrane Library, as well as the most commonly used Chinese databases (CNKI, Wanfang and CBM). Studies published between January 2015 and December 2023 on FRQoL in patients with IBD were included. The Joanna Briggs Institute (JBI) critical appraisal checklist was utilized to evaluate the methodological quality of the selected studies.ResultsFinally, only five studies met the inclusion criteria were reviewed, including three cross‐sectional studies and two case‐control studies. The Food‐related quality of life‐29 Scale (FR‐QoL‐29) with a total core of 145 was the most used instrument measuring FRQoL in patients with IBD. The mean scores of FRQoL ranged from 69.9 to 102.3 in adult patients with IBD and 94.3 in children. A diverse range of factors were associated with FRQoL, including socio‐demographic, clinical, psychological, diet‐related, and nutrient intake factors.ConclusionsThe main influencing factors of FRQoL among patients with IBD included disease activity status, severe symptoms, history of IBD surgery, negative emotion reaction, and restrictive eating behaviour. Clinicians should work in concert with dietitians, keeping an eye on the disease status, nutrition intake, and restrictive eating habits, assessing FRQoL and providing personalized dietary recommendation for the patients with IBD.
A single‐nucleus transcriptomic atlas characterizes cell types and their molecular features in the ovary of adult Nile tilapia
Authors: Yao Zhi Lei , Wang Xiao , Hu Chun Lei , Chen Fu Xiao , Chen Hong Ju , Jiang Shi‐Jin , Zhao Yan , Ji Xiang Shan 
Published: September 2024

AbstractIn fish species, there is limited analysis of signature transcriptome profiles at the single‐cell level in gonadal cells. Here, the molecular signatures of distinct ovarian cell categories in adult Nile tilapia (Oreochromis niloticus) were analysed using single‐nucleus RNA sequencing (snRNA‐seq). We identified four cell types (oogonia, oocytes, granulosa cell, and thecal cell) based on their specifically expressed genes and biological functions. Similarly, we found some key pathways involved in ovarian development that may affect germline–somatic interactions. A cell‐to‐cell communication network between the distinct cell types was constructed. We found that the bidirectional communication is mandatory for the development of germ cells and somatic cells in fish ovaries, and the granulosa cells and thecal cells play a central regulating role in the cell network in fish ovary. Additionally, we identified some novel candidate marker genes for various types of ovarian cells and also validated them using in situ hybridization. Our work reveals an ovarian atlas at the cellular and molecular levels and contributes to providing insights into oogenesis and gonad development in fish.
Diversification of flood risk management in the Netherlands: Implications for boundary judgement practices
Authors: Vinke‐de Kruijf Joanne , Groefsema Lisette , Snel Karin A. W. 
Published: September 2024

AbstractClimate change urges water managers in low‐lying deltas to diversify their flood risk management (FRM) strategies. To reduce residual risks, they increasingly need to incorporate spatial and other measures. This has implications for the boundary judgements made by water authorities, that is, the implicit and explicit decisions about who and what is relevant to include and consider. To understand these implications, we assess the boundary judgements made by a Dutch regional water authority in two diversification‐oriented frontrunner projects. We distinguish between three categories of judgements: (1) substantive: the scale, domains, time horizon and solutions that are considered; (2) participation: who is involved, to what extent and when; and (3) planning and decision: the flexibility of responsibilities, financing, planning and decision‐making. Our results show that, in both projects, most of the boundary judgements became wider over time as a result of pressure from or interactions with actors from outside the water sector. Hence, despite its ambition to diversify flood risk strategies, the water authority continued to draw boundaries that were too tight to allow for meaningful collaboration with actors outside the water sector. Considering the importance of reconfiguring practices in transforming FRM, we recommend more engaged research into practices.
CCL25 contributes to the pathogenesis of D‐Gal/LPS‐induced acute liver failure
Authors: Sun Fei , Wang Jingwei , Ji Xiangfen , Wang Zhenli , Gao Shuai , Wang Kai 
Published: September 2024

AbstractBackground and AimAcute liver failure (ALF) is a fatal clinical syndrome of severe hepatic dysfunction. Chemokines promote liver diseases by recruiting and activating immune cells. We aimed to investigate the role of C–C chemokine ligand 25 (CCL25) in ALF.MethodsAn ALF mouse model induced by D‐galactosamine/lipopolysaccharide was evaluated through liver hematoxylin and eosin staining and serum transaminase and cytokine measurement. CCL25 expression in serum was analyzed by ELISA and in liver by immunohistochemical staining and western blot. C–C chemokine receptor 9 (CCR9)‐expressing cells in the liver were identified by immunofluorescence staining. The effects of anti‐CCL25 on ALF were evaluated in vivo. Cytokine expression and migration of CCL25‐stimulated RAW264.7 macrophages were studied. We also investigated the role of anti‐CCL25 and BMS‐345541, an NF‐κB signaling inhibitor, in vitro. NF‐κB activation was assessed via western blot, and p65 nuclear translocation was detected using cellular immunofluorescence.ResultsALF mice showed severe histological damage and high serum levels of aminotransferase and inflammatory cytokines. Elevated CCL25 and NF‐κB activation was observed in vivo. CCR9 was expressed on macrophages in ALF mouse liver. ALF was suppressed after anti‐CCL25 treatment, with significant NF‐κB inhibition. In vitro, CCL25 induced strong migration and cytokine release in RAW264.7 macrophages, which were eliminated by anti‐CCL25 and BMS‐345541. Furthermore, the NF‐κB activation and p65 nuclear translocation induced by CCL25 were also inhibited by anti‐CCL25 and BMS‐345541.ConclusionCCL25 contributes to ALF development by inducing macrophage‐mediated inflammation via activation of the NF‐κB signaling.