bluuebunny/crossref_metadata_2025_split huggingface dataset:
Therapeutic JAK1 Inhibition Reverses Lupus Nephritis in a Mouse Model and Demonstrates Transcriptional Changes Consistent With Human Disease
Authors: Twomey Rachel E. , Perper Stuart J. , Westmoreland Susan V. , Srinivasan Swetha , Mathieu Suzanne L. , Frank Kristine E. , Karman Jozsef , Long Andrew J. , Housley William J. , Clarke Stephen H. 
Published: October 2024

ObjectiveJanus kinase family members are essential for signaling by multiple cytokines, including many implicated in systemic lupus erythematosus (SLE) pathogenesis. To test whether inhibition of JAK1 signaling can be efficacious in SLE, we used a JAK1‐selective inhibitor (ABT‐317) and evaluated its ability to ameliorate disease in murine SLE.MethodsEfficacy of ABT‐317 was evaluated using NZB/W‐F1 mice treated prophylactically and therapeutically. Primary endpoints were proteinuria, survival, and saliva production. Other endpoints included histological analysis of kidneys and salivary glands, flow cytometric analysis of splenic cell populations, and gene expression analysis by RNA sequencing in the kidneys, salivary glands, and blood. Publicly available human kidney gene transcription data were used to assess the translatability of the mouse findings.ResultsABT‐317 was efficacious when dosed prophylactically and prevented disease for up to two months after treatment cessation. When dosed therapeutically, ABT‐317 quickly reversed severe proteinuria and restored saliva production, as well as diminished kidney and salivary gland inflammation. ABT‐317‐induced changes in glomerular morphology coincided with normalization of a human nephrotic gene signature, suggesting translatability to human lupus nephritis (LN).ConclusionJAK1 inhibition prevented and reversed kidney and salivary gland manifestations of murine lupus with long‐lasting effects after treatment cessation. These data, along with the presence of JAK1 and nephrotic gene signatures in human LN glomeruli, suggest that a JAK1‐selective inhibitor may be an effective therapeutic in the treatment of human SLE and LN.
Fireproof Solid Polymer Electrolyte with Chemically Bonded Phosphorus Toward Stable and Safe Lithium‐Metal Battery
Authors: Li Zhenxi , Zhu Shuangshuang , Gao Shilun , He Yayue , Ding Hang , Yang Dandan , Yang Huabin , Cao Peng‐Fei 
Published: October 2024

AbstractLithium‐metal batteries (LMBs) are considered one of the most promising next‐generation high‐energy‐density battery systems. However, the leakage problem and fire hazard of commercial liquid electrolytes hinder their practical applications. Herein, a flame‐retardant solid polymer electrolyte (FRSPE) is fabricated by in situ polymerization of methyl methacrylate (MMA), allyl diglycol carbonate (ADC), and flame‐retardant monomer, i.e., diethyl vinyl phosphonate (DEVP), in which the phosphorus is chemically bonded to the polymer matrix to avoid the parasitic reaction between flame‐retardant molecules with lithium (Li) anode. Compared with the previously reported solid polymer electrolytes (SPEs) possessing free phosphorus, significantly increased efficiency of flame‐retardant and improved electrochemical performance can be achieved. With a wide electrochemical window (≈4.4V), high ionic conductivity (1.8 × 10−4 S cm−1), and superior compatibility with Li anode, the assembled Li/FRSPE/LiFePO4 (LFP) cell exhibits stable cycling over a wide temperature range (capacity retention of 70.9%@1000 cycles and 69.1%@200 cycles at 25 and 80 °C, respectively). Furthermore, the high‐voltage full cells, e.g., Li/LiCoO2 (LCO) and Li/LiNi0.8Co0.1Mn0.1O2 (NCM811), with FRSPE also deliver excellent cycling performance. The current design principle with flame‐retardant chemically bonded in the polymer framework can provide a new pathway for developing practical, safe, and stable LMBs.
Adaptive Optoelectronic Transistor Enabled by Nanoporous Patterning for Low‐Contrast Image Recognition
Authors: Wang Yiru , Hua Jing , He Xiang , Liu Shanshuo , Li Jiahao , Zhang Hongxin , Fu Jingwei , Wang Le , Li Wen , Yi Mingdong , Xie Linghai , Huang Wei , Ling Haifeng 
Published: October 2024

AbstractPhotoadaptive neuromorphic device is fundamental for artificial vision system to effectively perceive and accurately process information in complex light scenes. However, adaptive optoelectronic device remains a challenge due to the difficulty in achieving the light‐dependent modulation of charge dynamics. Here, an adaptive optoelectronic transistor enabled by the conformal nanoporous patterning that can perform the biomimetic eye functions and facilitate the precise contrast enhancement under harsh lighting conditions is reported. The enhanced light absorption, photoexciton separation, and charge injection properties are originated from the localized electric field in the nanoporous optoelectronic transistor, which further endow the light intensity‐dependent charge trapping and de‐trapping dynamics, realizing the adaptive decay rate of conduction states. Based on the improved device performances and the adaptive properties, an artificial vision system is constructed to present the biomimetic eye model with visual selective attention functions and a contrast enhancement in the low‐contrast sub‐images. The eye rotation and closing functions, as well as a high recognition accuracy of 95.4% for non‐ideal image with a contrast as low as 0.8% are demonstrated. This study provide an approach for the photoadaptive neuromorphic device and support their visual adaptation applications in biomimetic eye system.
Oligonucleotide‐Linked Lipid Nanoparticles as a Versatile mRNA Nanovaccine Platform
Authors: Im San Hae , Chung Youseung , Duskunovic Nevena , Choi Heewon , Park Su‐Hyung , Chung Hyun Jung 
Published: October 2024

AbstractAn effective delivery platform is crucial for the development of mRNA vaccines and therapeutics. Here, a versatile platform utilizing cholesterol‐modified oligonucleotides (L‐oligo) that bind to the mRNA within lipid nanoparticles (LNP), and enables the effective delivery of the mRNA into target cells is introduced. mRNA incorporated into LNPs via linkage with L‐oligo, termed oligonucleotide‐linked LNP (lnLNP), is superior in cellular uptake and transfection efficiency in target cells in vitro and in vivo, compared to the conventional LNP formulations. It is further applied lnLNP as an mRNA vaccine platform for SARS‐CoV‐2, demonstrating robust induction of neutralizing activity as well as polyfunctional SARS‐CoV‐2‐specific T‐cell response in vivo. The current strategy can be versatilely applied to different LNP platforms, for vaccine and therapeutic applications against various diseases, such as infections and cancers.
Protective and Damaging Mechanisms of Neuromelanin‐Like Nanoparticles and Iron in Parkinson's Disease
Authors: Liu Lizhu , Wang Tianying , Zhou Hao , Zheng Jinyang , Liu Qiang , Wang Wei , Liu Xinxin , Zhang Xiuming , Ge Dongtao , Shi Wei , Sun Yanan 
Published: October 2024

AbstractParkinson's disease (PD) pathology speculates that neuromelanin (NM) and iron ions play a significant role in physiological and pathological conditions of PD. Because the difficult accessibility of NM has limited targeted research, synthetic melanin‐like nanoparticles have been used to instead. In this report, the eumelanin and pheomelanin‐like polydopamine (PDA) nanoparticles are prepared that can be used to simulate natural NM with or without chelating iron ion and studied the redox effects in vitro and in vivo on neuronal cells and PD. The synthetic pheomelanin‐like PDA nanoparticles have much stronger redox activity than eumelanin‐like PDA nanoparticles without or with iron ion. They can protect neurons by scavenging reactive oxygen species (ROS), while cause neuronal cell death and PD due to excessive binding of iron ions. This work provides new evidence for the relationship among two structural components of NM and iron in PD as well as displays the different effects on the roles of eumelanin and pheomelanin in redox activity under physiological or pathological conditions, which provide a new effective choice for cellular and animal models of PD and offer theoretical guidance for targeted treatment and mechanism research on PD.
Sterically Hindered Organogels with Self‐Healing, Impact Response, and High Damping Properties
Authors: Cheng Jianfeng , Fu Songbao , Ma Shitao , Zhang Zhipeng , Ma Chunfeng , Zhang Guangzhao 
Published: October 2024

AbstractOrganogel materials are vital for impact or shock resistance because of their highly tailored dynamic properties. However, concurrently achieving excellent anti‐impact and damping performances, high stability, and self‐healing properties is challenging. Herein, a novel intelligent protective organogel (IPO) comprising a dynamic boronic ester containing poly(urethane–urea) as the network skeleton with a matching mesh size is synthesized, the network precisely entraps the hyperbranched fluid used as the bulky solvent via steric hindrance. The IPO exhibits self‐healing ability, excellent impact responsiveness (a 1950‐fold increase in flow stress under various impact speeds), and energy dissipation (the loss factor >0.8 from 10−4 to 104 Hz). The IPO maintains its dynamic mechanical properties during hot pressing and hydrolysis, exhibiting high stability. Furthermore, the IPO exhibits omnibearing protection. When used as a protective coating, the IPO dissipates the impact force by 87% and 89% of control upon passive and active impact, respectively. When used as a shock pad, it attenuates 91% of the amplitude in the high‐frequency vibrations. This study offers a novel perspective on the synthesis of tailored sterically hindered organogel and provides valuable insights into the development of next‐generation intelligent protective materials that exhibit impact and vibration resistance.
Hybrid Screen Printable Electrolyte for Large‐Scale Flexible Electrochromic Display Production
Authors: Leite Fábio A. S. , Wierzchowiec Piotr , Pinheiro Carlos , Maggini Laura , Bonifazi Davide 
Published: October 2024

AbstractThis study presents the development of a novel screen printable quasi‐solid polymer electrolyte (p‐QSPE) for Electrochromic Displays (ECDs) applications. p‐QSPE is composed of three key components: polyvinylidene fluoride (PVDF), a high‐dielectric constant polymer that ensures high ionic conductivity in solid‐state; glyceril propoxy triacrylate (GPTA), a UV‐cross‐linkable monomer that provides structure and durability for overprinting; titanium dioxide (TiO₂) nanoparticles, which modulate the electrolyte's rheological properties for screen printing; reducing the solvent (PC:EC) content to only 35.90 wt.%. Electrochemical Impedance Spectroscopy (EIS) revealed that this well‐designed formulation achieved an ionic conductivity of 1.17 × 10−3 S cm−1 at room temperature, surpassing the threshold required for commercial applications. Moreover, p‐QSPE facilitated the production of fully screen printed ECDs in an industrial printing line, streamlining their production process and achieving an optimal balance between printability, overprint resilience, and device performance. Operational tests for the ECDs showed fast switching times (<6 s for t90 and <2 s for t75) across a wide temperature range (−20 °C to 80 °C). Additionally, the electrolyte demonstrated low charge consumption (2.10 ± 0.11 mC cm−2) and a lifespan exceeding 10 000 cycles. These results highlight the potential of p‐QSPE as a screen printable, high‐performance electrolyte, capable of advancing ECD manufacturing by enabling the production of fully screen‐printed, performing ECDs.
UV­B Persistent Luminescence of CaF2:Gd3+ for Radiation Labeling and Tracing
Authors: Zhao Wenting , Li Leipeng , Li Tao , Qiu Jianrong , Yang Yanmin 
Published: October 2024

AbstractPersistent luminescence (PersL) has attracted considerable attention in the last two decades for its potential applications in the fields of emergency indicators, energy‐saving lighting, biomedical imaging, and dynamic anti‐counterfeiting. However, the wavelengths of PersL reported so far usually fall into the visible and near‐infrared range. The preparation of advanced optical materials bearing UV PersL remains elusive. Here the PersL characteristic of CaF2:Gd3+ is systematically studied. After exposure to X‐ray radiation, CaF2:Gd3+ continues to emit UV­‐B (UVB) PersL peaking at 313 nm, corresponding to the 6P7/2 → 8S7/2 transition of Gd3+. By virtue of X‐ray photoelectron spectroscopy measurements, the valence variation model is excluded to explain the UVB PersL of CaF2:Gd3+. Finally, it is demonstrated that such UVB PersL of CaF2:Gd3+ can be used for static labeling and dynamic tracing.
Synthesis of Vinyl Sulfones and Benzoxathiins via Base‐Catalyzed Reactions of o‐Hydroxyaryl Thiosulfonates and Ynones
Authors: Tang Delin , Zhang Fang , Luo Jinyun , Cai Zhihua , He Lin , Du Guangfen 
Published: October 2024

AbstractThe cyclization reaction and hydrosulfonylation reaction of ynones have been simultaneously realized through a single operation. Under the mediation of cesium carbonate, different S‐(α‐hydroxyaryl) aryl thiosulfonates reacted with various ynones to produce functionalized vinyl sulfones in 37%–83% yields with E‐selectivity. At the same time, a variety of benzoxathiins were formed in 42%–97% yields.
Catalyst‐Controlled Regiodivergent C−H Alkynylation of 2‐Pyridylthiophenes
Authors: Gui Yuting , Zhao Yaokun , Li Xingchi , Liang Taoyuan , Zhao Shuangliang , Zhang Zhuan 
Published: October 2024

AbstractDifferent catalysts are presented to overcome or augment a substrate's innate regioselectivity. Rhodium was found to overcome the innate C3‐selectivity via chelation‐assisted rhodation. Conversely, palladium was found to enhance the innate C5‐selectivity via electrophilic palladation. These reactions allow for the formation of a diverse range of synthetically versatile C3‐ and C5‐alkynylated products from 2‐pyridylthiophenes. Notably, this strategy was successfully employed in the straightforward synthesis of π‐extended functionalized 2‐pyridylthiophenes, which could be converted into more valuable compounds.
Visible‐Light Photoredox‐Catalyzed Trifunctionalization of Unactivated Alkenes via Diamidation and Cyano Migration
Authors: Mohamathu Ghouse Abuthayir , Maheswari Bathula , Murthy Akondi Srirama 
Published: October 2024

AbstractA visible‐light‐promoted, nitrogen‐centered radical‐initiated trifunctionalization of 5‐hexenonitriles via diamidation and 1,4‐cyano migration, using 1 mol% fac‐Ir(ppy)3 as the photoredox catalyst, is reported. In this protocol, the O‐acylhydroxylamine derivative acts as a bifunctional reagent, and the carbonitrile solvent also participates in the reaction. This transformation proceeds at room temperature, yielding a wide range of functionalized β‐amino nitriles, including the derivatives of natural products and pharmaceuticals.
Social, Economic, and Environmental Impacts of Bio‐Based Versus Fossil‐Derived Polyethylene Production
Authors: Trucillo Paolo , Rizzo Marianna , Errico Daniela , Di Maio Ernesto 
Published: October 2024

AbstractThe urgency to achieve carbon neutrality underlines the importance of shifting from carbon‐based fossils to renewable resources. Bio‐based polyethylene (bio‐PE) is a key component of this transition, which is obtained from natural and renewable sources such as sugarcane. The environmental impact of bio‐PE and fossil‐based PE production is compared building ad‐hoc sustainability indicators while exploring environmental, social, economic, and energetic aspects to provide a comprehensive evaluation. This methodology involves analyzing the entire lifecycle of both processes for polyethylene production, from extraction/harvesting to post‐disposal actions, such as mechanical recycling or incineration. The main goal is to represent numerous sustainability indicators on a radar diagram, thus comparing process scores of sustainability. Bio‐PE production has significantly higher scores than fossil carbon PE in terms of global warming potential (from cradle‐to‐gate), safety, and contribution to ozone depletion. Additionally, bio‐PE offers a quite better scenario in terms of mass input and energy operating costs. On one side, bio‐PE exhibits similar potential of eutrophication and acidification; on the other side, it also guarantees almost same potential revenues. This can address the choice to the most sustainable post‐disposal method, that regards the mechanical separation and re‐introduction of end‐of‐life PE into the manufacturing process.
Untreated Natural Wood‐Based Triboelectric Nanogenerator for Floor Charge Energy Harvesting
Authors: Antony Liya , Giuri Antonella , Mastria Rosanna , Kovalska Evgeniya , Kirkwood James , Danaa Alshammari , Russo Saverio , Craciun Monica F. , Rizzo Aurora 
Published: October 2024

AbstractTriboelectric nanogenerators (TENGs) represent an emerging technology that converts mechanical energy into electrical energy. Nonetheless, the most efficient TENGs are based on synthetic plastics or chemically treated materials. This study demonstrates a chemical‐free, natural wood‐based TENG with performance comparable to chemically treated wood‐TENGs. The natural wood is paired with different polymers as an opposite layers in contact‐separation mode, using various electrodes. The pristine wood‐polytetrafluoroethylene (PW: PTFE) TENG device with a large area of 3 × 3 cm2 exhibits a high open circuit voltage of 110 V, a short‐circuit current of 0.72 µA, and generates charge of 23.6 ± 0.3 nC. Finally, to illustrate the viability of PW: PTFE triboelectric devices for practical applications, a prototype with a 20 × 18 cm2 active area is discreetly inserted beneath a carpet to harness the energy generated by individuals walking or running across its surface. The cyclic nature of human motion ensures a sustained regimen of contact and separation, thereby yielding a consistent output of voltage and current, with a maximum open circuit voltage of 110 V, a short‐circuit current of 193 µA, and a charge of 3.5 µC. These findings suggest that pristine wood is a promising material for low‐cost and environmentally friendly TENGs.
Electrocatalytic Reduction of Nitrate/Nitrite to Ammonia on CuCo Nanoparticles Decorated N‐doped Carbon
Authors: Cang Chuanfei , Hua Rong , Shen Guoqing , Ma Mengxue , Chen Yu , Zheng Haoquan 
Published: October 2024

AbstractElectrocatalytic nitrate (NO3−)/nitrite (NO2−) reduction of ammonia (NH3) provides energy‐saving and sustainable methods for NH3 synthesis. However, both reactions involve multiple electrons and multiple protons, making the reaction process complex with many by‐products. Thus, efficient catalysts are needed to improve the selectivity and yield of ammonia. Herein, the CuCo nanoparticles decorated N‐doped carbon (CuCo‐NC) derived from zeolitic imidazolate framework (ZIF) with a cross‐shaped leaf structure has been synthesized as electrocatalysts for NO3−/ NO2− reduction. The obtained CuCo‐NC possesses Cu‐doped Co metallic nanoparticles, and hierarchical structure, and demonstrated to exhibit good activity and selectivity in electrocatalytic NO3−/NO2− reduction to NH3 synthesis. In the electrocatalytic NO3− reduction of NH3, the Faraday efficiency of NH3 reached 97% and the yield reached 7.17 mg h−1 cm−2 at −0.3 V. In the electrocatalytic NO2− reduction of NH3, the Faraday efficiency of NH3 reached 92% and the yield reached 8.34 mg h−1 cm−2 at −0.3 V, demonstrating good stability in the cyclic electrolysis of both reactions. The CuCo‐NC with a cross‐shaped leaf structure exhibits excellent electrocatalytic NO3−/NO2− reduction activity of CuCo‐NC and therefore highlights the promising potential of bimetallic electrocatalysts for NH3 synthesis.
Water‐Based Activated Carbon Ink for Printed Flexible Biodegradable Supercapacitors
Authors: Sharma Neha , Kandregula Ganapathi Rao , Koshy Aarju Mathew , Ramanujam Kothandaraman , Ray Debdutta , Swaminathan Parasuraman 
Published: October 2024

AbstractFlexible and printed supercapacitors (SCs) have emerged as reliable power sources for wearable and portable electronics. However, developing these SCs as sustainable and eco‐benign, with high electrochemical performance, remains a challenge. Herein, scalable fabrication of SCs is demonstrated by formulating an activated carbon (AC) printable ink for the direct ink writing (DIW) of SCs. A water‐based ink is prepared using a bio‐degradable cellulose‐based, sodium carboxymethylcellulose (Na CMC), binder replacing the typically used fluorinated binders, which are not environmentally friendly. Na CMC provides a stable ink dispersion with added mechanical and chemical stability to the printed SCs. The AC‐Na CMC electrode produced 127.8 mF cm−2 of specific capacitance. This AC‐Na CMC ink is used to develop fully printed film‐SCs and micro‐SCs (m‐SCs). The m‐SC is fabricated with a printing resolution of 150 µm on photo paper. Using DIW enables scalable production, which is demonstrated by printing an array of m‐SCs to power a micro‐LED. The printed m‐SC also demonstrates high mechanical flexibility, retaining 89.6% of its original capacitance at a bending angle of 90⁰. Na CMC as binder and photopaper as the substrate results in the production of biodegradable SCs extending their applicability to the field of transient electronics.
Monolayer Sodium Titanate Nanobelts as a Highly Efficient Anode Material for Sodium‐Ion Batteries
Authors: Xia Qingbing , Liang Yaru , Cooper Emily R. , Ko Cheng‐Lin , Hu Zhe , Li Weijie , Chou Shulei , Knibbe Ruth 
Published: October 2024

AbstractMonolayer atomic crystals show significant advantages in improving charge storage kinetics for electrode materials. While notable progress is made, challenges remain in producing nanocrystals with desirable configurations, dimensions, and crystallographic properties. Here, 1D single‐crystal nanobelts assembled from monolayer sodium titanate nanobelts are reported with highly exposed active sites as anode materials for sodium‐ion batteries (SIBs). The unique structural properties of the 1D single‐crystal nanobelts offer excellent electrochemical activity, electrochemo‐mechanical stability, and well‐maintained structural integrity, leading to highly efficient sodium ion storage performance. Insights into the electrochemical reaction processes, as revealed by in situ transmission electron microscopy, in situ synchrotron X‐ray diffraction, and theoretical calculations, indicate that the 1D single‐crystal nanobelts enable favorable sodium ion storage kinetics and a low‐strain characteristic. This facilitates fast charge/discharge capability and long‐term cycling stability for up to 5000 cycles at 20 C. Moreover, the 1D single‐crystal nanobelts demonstrate practical applicability. A pouch cell assembled with the 1D single‐crystal nanobelts anode and iron‐based Prussian blue cathode exhibits highly stable cycling, achieving a low capacity fading ratio of ≈0.05% per cycle over 150 cycles. This study provides an innovative design principle to enhance the charge storage capability of electrode materials through intelligent structural nanoengineering.
Correlating the Photoshunt with Charge‐Collection Losses in Organic Solar Cells
Authors: Kim Eunchi , Christen Leonard , Kirchartz Thomas 
Published: October 2024

AbstractThe low charge carrier mobility of molecular materials is one of the key obstacles to achieving higher efficiencies in organic photovoltaics. Therefore, understanding and quantifying charge collection losses owing to low mobility is an important challenge in organic photovoltaics and other emerging photovoltaic technologies. Here, an approach is proposed to use the photoshunt and its dependence on light intensity as an easily accessible indicator of charge‐collection losses. The physical meaning of the photoshunt is explored using drift‐diffusion simulations and an analytical model. The results show that the recombination current visible as the photoshunt is decreasing with increasing charge carrier mobility. Furthermore, a framework is presented for evaluating the short‐circuit current losses in experimental data using a photoshunt. The study reveals that the charge‐collection efficiency at shortcircuit is strongly influenced by the charge carrier mobility and light intensity.