bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of MIL-101(Fe)-embedded biopolymeric films and their biomedical applications
Authors: Kocaaga Banu , Bagimsiz Gamze , Alev Ibrahim Avni , Miavaghi Mehran Aliari , Sirkecioglu Ahmet , Batirel Saime , Guner Fatma Seniha 
Published: September 2024

AbstractThe development of wound-dressing materials with superior therapeutic effects, controlled bioactive agent release, and optimal mechanical properties is crucial in healthcare. This study introduces innovative hydrogel films designed for the sustained release of the local anesthetic drug Procaine (PC), triggered by pH changes. These films are composed of MIL-101(Fe) particles and pectin polymers. MIL-101(Fe) was chosen for its high surface area, stability in aqueous environments, and biocompatibility, ensuring low toxicity to normal cells. MIL-101(Fe)-embedded-pectin hydrogels were synthesized and characterized using Fourier-transformed infrared (FTIR) spectroscopy, thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), X-ray diffraction (XRD), inductively coupled plasma (ICP) spectrometry, particle size analysis, and goniometry. Rheological analysis assessed the hydrogels’ viscoelastic behavior, and UV-spectrophotometry was utilized for drug loading and release studies. The hydrogels exhibited shear-thinning properties, enhancing shape adaptability and recovery, crucial for wound-dressing applications. Controlled drug release was achieved by maintaining the PC solution’s pH between 8.2 and 9.8 during the drug-loading step. The hydrogel film’s impact on wound healing was evaluated through an in vitro wound healing assay, and cytotoxicity was assessed using a WST-1 cell proliferation assay with human dermal fibroblast cells. Results demonstrated that pectin composites enhance cell viability and support fibroblast cell migration without adverse effects, indicating their potential for effective wound healing applications. This study highlights the potential of MIL-101(Fe)-embedded-pectin hydrogels in advancing wound care technology.
Graphical Abstract

MIL-101(Fe)-embedded pectin film as wound dressing
Capturing the unobservable in AI development: proposal to account for AI developer practices with ethnographic audit trails (EATs)
Authors: Wu Yung-Hsuan 
Published: September 2024

AbstractThe prevalence of artificial intelligence (AI) tools has inspired social studies researchers, ethicists, and policymakers to seriously examine AI’s sociopolitical and ethical impacts. AI ethics literature provides guidance on which ethical principles to implement via AI governance; AI auditing literature, especially ethics-based auditing (EBA), suggests methods to verify if such principles are respected in AI model development and deployment. As much as EBA methods are abundant, I argue that most currently take a top-down and post-hoc approach to AI model development: Existing EBA methods mostly assume a preset of high-level, abstract principles that can be applied universally across contexts; meanwhile, current EBA is only conducted after the development or deployment of AI models. Taken together, these methods do not sufficiently capture the very developmental practices surrounding the constitution of AI models on a day-to-day basis. What goes on in an AI development space and the very developers whose hands write codes, assemble datasets, and design model architectures remain unobserved and, therefore, uncontested. I attempt to address this lack of documentation on AI developers’ day-to-day practices by conducting an ethnographic “AI lab study” (termed by Florian Jaton), demonstrating just how much context and empirical data can be excavated to support a whole-picture evaluation of AI models’ sociopolitical and ethical impacts. I then propose a new method to be added to the arsenal of EBA: Ethnographic audit trails (EATs), which take a bottom-up and in-progress approach to AI model development, capturing the previously unobservable developer practices.
The entangled human being – a new materialist approach to anthropology of technology
Authors: Puzio Anna 
Published: September 2024

AbstractTechnological advancements raise anthropological questions: How do humans differ from technology? Which human capabilities are unique? Is it possible for robots to exhibit consciousness or intelligence, capacities once taken to be exclusively human? Despite the evident need for an anthropological lens in both societal and research contexts, the philosophical anthropology of technology has not been established as a set discipline with a defined set of theories, especially concerning emerging technologies. In this paper, I will utilize a New Materialist approach, focusing particularly on the theories of Donna Haraway and Karen Barad, to explore their potential for an anthropology of technology. I aim to develop a techno-anthropological approach that is informed and enriched by New Materialism. This approach is characterized by its relational perspective, a dynamic and open conception of the human being, attention to diversity and the dynamics of power in knowledge production and ontology, and an emphasis on the non-human. I aim to outline an anthropology of technology centered on New Materialism, wherein the focus, paradoxically, is not exclusively on humans but equally on non-human entities and the entanglement with the non-human. As will become clear, the way we understand humans and their relationship with technology is fundamental for our concepts and theories in ethics of technology.
Spatial and Temporal Analysis of Severe Fever with Thrombocytopenia Syndrome in Anhui Province from 2011 to 2023
Authors: Chu Xiu-Jie , Song Dan-Dan , Chu Na , Wu Jia-Bing , Wu Xiaomin , Chen Xiu-Zhi , Li Ming , Li Qing , Chen Qingqing , Sun Yong , Gong Lei 
Published: September 2024

Abstract
Objective
To analyze the spatial autocorrelation and spatiotemporal clustering characteristics of severe fever with thrombocytopenia syndrome(SFTS) in Anhui Province from 2011 to 2023.

Methods
Data of SFTS in Anhui Province from 2011 to 2023 were collected. Spatial autocorrelation analysis was conducted using GeoDa software, while spatiotemporal scanning was performed using SaTScan 10.0.1 software to identify significant spatiotemporal clusters of SFTS.

Results
From 2011 to 2023, 5720 SFTS cases were reported in Anhui Province, with an average annual incidence rate of 0.7131/100,000. The incidence of SFTS in Anhui Province reached its peak mainly from April to May, with a small peak in October. The spatial autocorrelation results showed that from 2011 to 2023, there was a spatial positive correlation(P < 0.05) in the incidence of SFTS in all counties and districts of Anhui Province. Local autocorrelation high-high clustering areas are mainly located in the south of the Huaihe River. The spatiotemporal scanning results show three main clusters of SFTS in recent years: the first cluster located in the lower reaches of the Yangtze River, the eastern region of Anhui Province; the second cluster primarily focused on the region of the Dabie Mountain range, while the third cluster primarily focused on the region of the Huang Mountain range.

Conclusions
The incidence of SFTS in Anhui Province in 2011–2023 was spatially clustered.
Climate Change Projections for Stroke Incidence in Taiwan: Impact of 2 °C and 4 °C Global Warming Level
Authors: Wu Wei-Te , Kono Miku , Lee Chuan-Pin , Chang Yu-Yin , Yang Yao-Hsu , Lin Ching-Chun , Liu Tzu-Ming , Li Hsin-Chi , Chen Yung-Ming , Chen Pau-Chung 
Published: September 2024

Abstract
Objectives
This study aimed to establish the exposure-lag-response effect between daily maximum temperature and stroke-related emergency department visits and to project heat-induced stroke impacts under global warming levels (GWL) of 2 °C and 4 °C.

Methods
Stroke-related emergency department visits in Taiwan from 2001 to 2020 were identified using the National Health Insurance Research Database (NHIRD). The study population consisted of 1,100,074 initial stroke cases matched with 2,200,148 non-stroke controls. We employed Distributed Lag Nonlinear Models (DLNM) in a case-crossover study to investigate the association between temperature and stroke. Generalized Estimating Equations (GEE) models with a Poisson function were used to correlate high-temperature exposure with annual stroke incidence rates. Projections were made under two global warming scenarios, GWL 2.0 °C and 4.0 °C, using Coupled General Circulation Model (GCMs). Baseline data from 1995 to 2014 were transformed for spatial distribution at the township level. Geographic Information System (GIS) spatial analysis was performed using Quantum GIS 3.2.0 software.

Results
DLNM exposure-lag-response effect revealed that daily maximum temperature exceeding 34 °C significantly increased the risk of stroke-related emergency department visits, particularly for ischemic stroke. Under the 2 °C GWL scenario, the frequency of days with temperatures surpassing 34 °C is projected to rise substantially by the median year of 2042, with a further increase to 92.6 ± 18.0 days/year by 2065 under the 4 °C GWL scenario. Ischemic stroke showed the highest increase in temperature-related incidence rates, notably rising from 7.80% under the GWL 2 °C to 36.06% under the GWL 4 °C. Specifically, the annual temperature-related incidence rate for ischemic stroke is expected to increase significantly by 2065. Regions such as Taichung, Hsinchu, Yilan, and Taitung demonstrated pronounced changes in heat-related ischemic stroke incidence under the GWL 4 °C.

Conclusions
The findings emphasize the importance of addressing temperature-related stroke risks, particularly in regions projected to experience significant temperature increases. Effective mitigation strategies are crucial to reduce the impact of rising temperatures on stroke incidence and safeguard public health.
Multi‐Hazard Interrelationships and Risk Scenarios in Urban Areas: A Case of Nairobi and Istanbul
Authors: Šakić Trogrlić Robert , Thompson Harriet E. , Menteşe Emin Yahya , Hussain Ekbal , Gill Joel C. , Taylor Faith E. , Mwangi Emmah , Öner Emine , Bukachi Vera G. , Malamud Bruce D. 
Published: September 2024

AbstractThis paper introduces a methodology for characterizing the breadth of natural hazard types, hazard interrelationships, and risk scenarios in Global South urban areas, focusing on Nairobi, Kenya, and Istanbul, Türkiye. Our approach involves (a) a comprehensive characterization of multi‐hazards and their interrelationships in an urban setting, (b) collaborative development of relevant multi‐hazard scenarios with local disaster risk reduction (DRR) stakeholders, and (c) analysis of the potential for integrating these scenarios into urban DRR efforts. Using a critical review of 135 sources (academic and gray literature, databases, online, and social media), we identify 19 natural hazard types that might influence Nairobi and 23 in Istanbul. We further identified in Nairobi 88 and Istanbul 105 hazard interrelationship pairs (e.g., an earthquake triggering landslides) out of a possible 576 interrelationships. These findings are cataloged in an extensive database, which informs the creation of multi‐hazard risk scenario exemplars for each city. These exemplars are refined through stakeholder engagement, involving four workshops (47 participants) and nine semi‐structured interviews with local DRR stakeholders. Despite the identified benefits, this engagement reveals a significant gap in integrating multi‐hazards into current urban policy and practice. Governance challenges are highlighted as a key barrier, but opportunities for better integration are also identified, including evolving policies and growing awareness among urban actors. Our approach, particularly relevant in data‐scarce urban areas of low‐ and middle‐income countries, provides a framework for exploring multi‐hazard issues in various urban contexts.
Surface Quasi Geostrophic Reconstruction of Vertical Velocities and Vertical Heat Fluxes in the Southern Ocean: Perspectives for SWOT
Authors: Carli Elisa , Siegelman Lia , Morrow Rosemary , Vergara Oscar 
Published: September 2024

AbstractMesoscale currents account for 80% of the ocean's kinetic energy, whereas submesoscale currents capture 50% of the vertical velocity variance. SWOT's first sea surface height (SSH) observations have a spatial resolution an order of magnitude greater than traditional nadir‐looking altimeters and capture mesoscale and submesoscale features. This enables the derivation of submesoscale vertical velocities, crucial for the vertical transport of heat, carbon and nutrients between the ocean interior and the surface. This work focuses on a mesoscale energetic region south of Tasmania using a coupled ocean‐atmosphere simulation at km‐scale resolution and preliminary SWOT SSH observations. Vertical velocities (w), temperature anomalies and vertical heat fluxes (VHF) from the surface down to 1,000 m are reconstructed using effective surface Quasi‐Geostrophic (sQG) theory. An independent method for reconstructing temperature anomalies, mimicking an operational gridded product, is also developed. Results show that sQG reconstructs 90% of the modeled w and VHF rms at scales down to 30 km just below the mixed layer and 50%–70% of the rms for scales larger than 70 km at greater depth, with a spatial correlation of 0.6. The reconstruction is spectrally coherent for scales larger than 30–40 km at the surface, slightly degrading ( 0.55) at depth. Two temperature anomaly data sets yield similar results, indicating the dominance of w on VHF. The RMS of sQG and VHF derived from SWOT are twice as large as those derived from conventional altimetry, highlighting the potential of SWOT for reconstructing energetic meso and submesoscale dynamics in the ocean interior.
Emerin mislocalization during chromatin bridge resolution can drive prostate cancer cell invasiveness in a collagen-rich microenvironment
Authors: Popęda Marta , Kowalski Kamil , Wenta Tomasz , Beznoussenko Galina V. , Rychłowski Michał , Mironov Alexander , Lavagnino Zeno , Barozzi Sara , Richert Julia , Bertolio Rebecca , Myszczyński Kamil , Szade Jolanta , Bieńkowski Michał , Miszewski Kevin , Matuszewski Marcin , Żaczek Anna J. , Braga Luca , Del Sal Giannino , Bednarz-Knoll Natalia , Maiuri Paolo , Nastały Paulina 
Published: September 2024

AbstractMicronuclei (MN) can form through many mechanisms, including the breakage of aberrant cytokinetic chromatin bridges. The frequent observation of MN in tumors suggests that they might not merely be passive elements but could instead play active roles in tumor progression. Here, we propose a mechanism through which the presence of micronuclei could induce specific phenotypic and functional changes in cells and increase the invasive potential of cancer cells. Through the integration of diverse in vitro imaging and molecular techniques supported by clinical samples from patients with prostate cancer (PCa) defined as high-risk by the D’Amico classification, we demonstrate that the resolution of chromosome bridges can result in the accumulation of Emerin and the formation of Emerin-rich MN. These structures are negative for Lamin A/C and positive for the Lamin-B receptor and Sec61β. MN can act as a protein sinks and result in the pauperization of Emerin from the nuclear envelope. The Emerin mislocalization phenotype is associated with a molecular signature that is correlated with a poor prognosis in PCa patients and is enriched in metastatic samples. Emerin mislocalization corresponds with increases in the migratory and invasive potential of tumor cells, especially in a collagen-rich microenvironment. Our study demonstrates that the mislocalization of Emerin to MN results in increased cell invasiveness, thereby worsening patient prognosis.
Harnessing the capabilities of VCSELs: unlocking the potential for advanced integrated photonic devices and systems
Authors: Pan Guanzhong , Xun Meng , Zhou Xiaoli , Sun Yun , Dong Yibo , Wu Dexin 
Published: September 2024

AbstractVertical cavity surface emitting lasers (VCSELs) have emerged as a versatile and promising platform for developing advanced integrated photonic devices and systems due to their low power consumption, high modulation bandwidth, small footprint, excellent scalability, and compatibility with monolithic integration. By combining these unique capabilities of VCSELs with the functionalities offered by micro/nano optical structures (e.g. metasurfaces), it enables various versatile energy-efficient integrated photonic devices and systems with compact size, enhanced performance, and improved reliability and functionality. This review provides a comprehensive overview of the state-of-the-art versatile integrated photonic devices/systems based on VCSELs, including photonic neural networks, vortex beam emitters, holographic devices, beam deflectors, atomic sensors, and biosensors. By leveraging the capabilities of VCSELs, these integrated photonic devices/systems open up new opportunities in various fields, including artificial intelligence, large-capacity optical communication, imaging, biosensing, and so on. Through this comprehensive review, we aim to provide a detailed understanding of the pivotal role played by VCSELs in integrated photonics and highlight their significance in advancing the field towards efficient, compact, and versatile photonic solutions.
The multifaceted role of mitochondria in autism spectrum disorder
Authors: Khaliulin Igor , Hamoudi Wajeha , Amal Haitham 
Published: September 2024

Abstract
Normal brain functioning relies on high aerobic energy production provided by mitochondria. Failure to supply a sufficient amount of energy, seen in different brain disorders, including autism spectrum disorder (ASD), may have a significant negative impact on brain development and support of different brain functions. Mitochondrial dysfunction, manifested in the abnormal activities of the electron transport chain and impaired energy metabolism, greatly contributes to ASD. The aberrant functioning of this organelle is of such high importance that ASD has been proposed as a mitochondrial disease. It should be noted that aerobic energy production is not the only function of the mitochondria. In particular, these organelles are involved in the regulation of Ca2+ homeostasis, different mechanisms of programmed cell death, autophagy, and reactive oxygen and nitrogen species (ROS and RNS) production. Several syndromes originated from mitochondria-related mutations display ASD phenotype. Abnormalities in Ca2+ handling and ATP production in the brain mitochondria affect synaptic transmission, plasticity, and synaptic development, contributing to ASD. ROS and Ca2+ regulate the activity of the mitochondrial permeability transition pore (mPTP). The prolonged opening of this pore affects the redox state of the mitochondria, impairs oxidative phosphorylation, and activates apoptosis, ultimately leading to cell death. A dysregulation between the enhanced mitochondria-related processes of apoptosis and the inhibited autophagy leads to the accumulation of toxic products in the brains of individuals with ASD. Although many mitochondria-related mechanisms still have to be investigated, and whether they are the cause or consequence of this disorder is still unknown, the accumulating data show that the breakdown of any of the mitochondrial functions may contribute to abnormal brain development leading to ASD. In this review, we discuss the multifaceted role of mitochondria in ASD from the various aspects of neuroscience.
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation
Authors: Jin Ying , Huang Run-Jie , Guan Wen-Long , Wang Zhi-Qiang , Mai Zong-Jiong , Li Yu-Hong , Xiao Jian , Zhang Xing , Zhao Qi , Chen Shi-Fu , Liu Ming , Shi Yan-Xia , Wang Feng , Xu Rui-Hua 
Published: September 2024

AbstractPatients carrying mutations in polymerase epsilon/polymerase delta have shown positive responses to immune checkpoint inhibitors. Yet, prospective trials exploring the efficacy in those with polymerase epsilon/polymerase delta mutations are still lacking. A phase II clinical trial was initiated to evaluate the efficacy of toripalimab, a humanized IgG4K monoclonal antibody to human PD-1, in patients with advanced solid tumors with unselected polymerase epsilon/polymerase delta mutations but without microsatellite instability-high. A total of 15 patients were enrolled, 14 of whom were assessed for treatment efficacy. There was a 21.4% overall response rate, with a disease control rate of 57.1%. The median overall survival and median progression-free survival were 17.9 (95% CI 13.5-not reach) months and 2.5 (95% CI 1.4-not reach) months, respectively. For patients with exonuclease domain mutations, the objective response rate was 66.7% (2/3), with a disease control rate of 66.7% (2/3). For those with non-exonuclease domain mutations, the rates were 9.1% (1/11) and 54.5% (6/11), respectively. Notably, patients with PBRM1 gene mutations exhibited a high response rate to toripalimab at 75.0% (3/4). This study showed that neither the exonuclease domain mutations nor non-exonuclease domain mutations could fully predict the efficacy of immunotherapy, urging the need for more investigations to clarify potential immune sensitization differences within polymerase epsilon/polymerase delta mutation variants.
Reduced Intensity transplantation vs chemotherapy in CR1. A prospective, pseudorandomized study in 50–70 year old AML patients
Authors: Brune Mats , Kiss Thomas , Anderson Harald , Nicklasson Malin , Delage Robert , Finke Jürgen , Gedde-Dahl Tobias , Hébert Josée , Höglund Martin , Kaare Ain , Lazarevic Vladimir , Möllgård Lars , Remes Kari , Ritchie David , Spyridonidis Alexandros , Sabloff Mitchell , Spearing Ruth , Wallhult Elisabeth , Ljungman Per 
Published: September 2024

AbstractThe aim of this prospective, international multicenter, pseudorandomized study comparing RICT HCT to standard-of-care chemotherapy in intermediate- or high-risk AML patients 50–70 years using the donor versus no-donor concept. Part 1 included only patients with potential family donors (RD) at the date of HLA-typing of the first potential sibling or CR-date, if later. Part 2 allowed the inclusion of patients without a possible sibling donor using the start of an unrelated donor (URD) search as inclusion date. 360 patients were registered and 309 analyzed. The median follow-up was 47 months (1–168). There was no difference in overall survival (OS) between the RD (n = 124) and the Control (n = 77) groups (p = 0.50, 3-year OS RD: 0.41(95% CI; 0.32–0.50); Controls: 0.49 (95% CI; 0.37–0.59)). The main cause of death was relapse (67% RD; 88% Controls). In Part 2, the 3-year OS was 0.60 (95% CI 0.50–0.70) for URD-HCT (n = 86) and 0.37 (95% CI 0.13–0.62) for Controls (n = 20), respectively (p = 0.10). When analyzing transplanted patients (Part 2), the OS at 3-years was higher for URD-HCT than RD-HCT (0.67 (0.55–0.76) vs. 0.42 (0.26–0.57; p = 0.005). This study doesn’t support elderly HLA-identical siblings as donors for older AML patients undergoing a RICT allogeneic HCT in first CR.