bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental and genetic regulation of the human cortex transcriptome in schizophrenia
Authors: Jaffe Andrew E , Straub Richard E , Shin Joo Heon , Tao Ran , Gao Yuan , Collado Torres Leonardo , Kam-Thong Tony , Xi Hualin S , Quan Jie , Chen Qiang , Colantuoni Carlo , Ulrich William S , Maher Brady J. , Deep-Soboslay Amy ,   The BrainSeq Consortium, Cross Alan , Brandon Nicholas J. , Leek Jeffrey T , Hyde Thomas M. , Kleinman Joel E. , Weinberger Daniel R 
Published: April 2017

SummaryGWAS have identified 108 loci that confer risk for schizophrenia, but risk mechanisms for individual loci are largely unknown. Using developmental, genetic, and illness-based RNA sequencing expression analysis, we characterized the human brain transcriptome around these loci and found enrichment for developmentally regulated genes with novel examples of shifting isoform usage across pre- and post-natal life. We found widespread expression quantitative trait loci (eQTLs), including many with transcript specificity and previously unannotated sequence that were independently replicated. We leveraged this eQTL database to show that 48.1% of risk variants for schizophrenia associated with nearby expression. Within patients and controls, we implemented a novel algorithm for RNA quality adjustment, and identified 237 genes significantly associated with diagnosis that replicated in an independent case-control dataset. These genes implicated synaptic processes and were strongly regulated in early development (p < 10-20). These data offer new targets for modeling schizophrenia risk in cellular systems.
Intracellular passage of Na+in an active state g-protein coupled receptor
Authors: Vickery Owen N. , Carvalheda Catarina A. , Zaidi Saheem A. , Pisliakov Andrei V. , Katritch Vsevolod , Zachariae Ulrich 
Published: April 2017

ABSTRACTPlaying a central role in cell signalling, GPCRs have evolved into the largest superfamily of membrane proteins and form the majority of drug targets in humans. How extracellular agonist binding triggers the activation of GPCRs and associated intracellular effector proteins remains, however, poorly understood. High resolution structural studies have recently revealed that inactive class-A GPCRs harbour a conserved binding site for Na+ions in the centre of their transmembrane domain, accessible from the extracellular space. Here, we show that the opening of a conserved hydrated channel in the activated state receptors allows the Na+ion to egress from its binding site into the cytosol. Coupled with protonation changes, this ion movement occurs without significant energy barriers, and can be driven by physiological transmembrane ion and voltage gradients. We propose that Na+ion exchange with the cytosol is a key step in GPCR activation, which locks receptors in long-lived active-state conformations.
SeedVicious: analysis of microRNA target and near-target sites
Authors: Marco Antonio 
Published: April 2017

ABSTRACTHere I describe seedVicious, a versatile microRNA target site prediction software that can be easily fitted into annotation pipelines and run over custom datasets. SeedVicious finds microRNA canonical sites plus other, less efficient, target sites. The program also detects near-target sites, which have one nucleotide different from a canonical site. Near-target sites are important to study population variation in microRNA regulation. Here I show that near-target sites can also be functional sites. Among other features, seedVicious can also compute evolutionary gains/losses of target sites using maximum parsimony. SeedVicious does not aim to outperform but to complement existing microRNA prediction tools. For instance, the precision of TargetScan is doubled (from 11% to ~22%) when we filter predictions by the distance between target sites using our program. The software is written in Perl and runs on 64-bit Unix computers (Linux and MacOS X). Users can also try the program in a dedicated web-server by uploading custom data, or browsing pre-computed predictions. SeedVicious and its associated web-server and database (SeedBank) are distributed under the GPL/GNU license.
SOMSC: Self-Organization-Map for High-Dimensional Single-Cell Data of Cellular States and Their Transitions
Authors: Peng Tao , Nie Qing 
Published: April 2017

AbstractMeasurement of gene expression levels for multiple genes in single cells provides a powerful approach to study heterogeneity of cell populations and cellular plasticity. While the expression levels of multiple genes in each cell are available in such data, the potential connections among the cells (e.g. the cellular state transition relationship) are not directly evident from the measurement. Classifying the cellular states, identifying their transitions among those states, and extracting the pseudotime ordering of cells are challenging due to the noise in the data and the high-dimensionality in the number of genes in the data. In this paper we adapt the classical self-organizing-map (SOM) approach for single-cell gene expression data (SOMSC), such as those based on single cell qPCR and single cell RNA-seq. In SOMSC, a cellular state map (CSM) is derived and employed to identify cellular states inherited in the population of the measured single cells. Cells located in the same basin of the CSM are considered as in one cellular state while barriers among the basins in CSM provide information on transitions among the cellular states. A cellular state transitions path (e.g. differentiation) and a temporal ordering of the measured single cells are consequently obtained. In addition, SOMSC could estimate the cellular state replication probability and transition probabilities. Applied to a set of synthetic data, one single-cell qPCR data set on mouse early embryonic development and two single-cell RNA-seq data sets, SOMSC shows effectiveness in capturing cellular states and their transitions presented in the high-dimensional single-cell data. This approach will have broader applications to analyzing cellular fate specification and cell lineages using single cell gene expression data
Feeling better when buying more? Harmonious passion and obsessive passion in online food group buying
Authors: Wang Yao-Chin , Tsai Chen-Tsang Simon 
Published: April 2017

PurposeThe purpose of this paper is to understand consumers’ passion types in online food group buying (OFGB) and the following outcomes in buying behavior and mental status.Design/methodology/approachThe research setting of this study is a Facebook group specifically for food buying, with population of 2,387 members who are interested in OFGB. Among 2,387 members in the case group, there were 1,286 members clicked on the questionnaire, and 254 of them participated in the survey and returned valid responses. In total, 254 valid questionnaires were collected for 19.75 percent usable response rate (254 out of 1,286).FindingsResults of this study proved that harmonious passion can improve both long-term intrinsic enjoyment and short-term positive feelings, while exert no effects on impulse buying. On the other hand, obsessive passion can significantly stimulate both impulse buying and compulsive buying, and strengthen short-term positive feelings as well.Originality/valueIt is interesting to find that buying more does not make consumers feel better based on the evidence that impulse buying and compulsive buying performed no positive influences to both short-term and long-term mental status.
Corporate social responsibility as shared value creation: toward a communicative approach
Authors: Høvring Christiane Marie 
Published: April 2017

Purpose
The debate on corporate social responsibility (CSR) as shared value creation is trapped between management scholars and business ethics scholars, focusing merely on the distribution of values from an outcome-oriented perspective. The result is a juxtaposition of shared value from either a corporate or a societal perspective, providing only little attention to the actual communication processes supporting the creation of shared value. The purpose of this paper is to re-conceptualize shared value creation from a communicative approach as an alternative to the current situation caught between the management and societal perspectives.

Design/methodology/approach
Building upon recent constitutive models of CSR communication, this conceptual paper explores the potentials and implications of re-conceptualizing shared value creation as an alternative approach that recognizes the tensional interaction processes related to shared value creation.

Findings
The paper suggests a new conceptualization of shared value creation, which is sensitive to and able to advance the understanding of the tensional and conflictual interaction processes in which the continuous negotiation of corporate and stakeholder interests, values and agendas may facilitate a new understanding of shared value creation.

Practical implications
In order to succeed with the shared purpose of creating shared value (CSV), the company and the multiple stakeholders should neither disregard nor idealize the interaction processes related to shared value creation; rather, they should acknowledge that processes filled with tensions and conflicts are prerequisites for CSV.

Originality/value
A re-conceptualization of shared value creation that provides an alternative approach that is sensitive toward the tensions and conflicts occurring between corporate voice and multiple stakeholder voices.
Extra care: viable for couples living with dementia?
Authors: Poyner Christopher , Innes Anthea , Dekker Francesca 
Published: April 2017

Purpose
The perspectives of people with dementia and their care partners regarding “extra care” housing are currently unknown. The purpose of this paper is to report findings of a consultation study exploring the perceived barriers and facilitators of a relocation to extra care housing, from the perspective of people living with dementia, and their care partners.

Design/methodology/approach
Fieldwork consisted of paired or 1-1 interviews and small focus groups with potential users of an alternative model of extra care support for people living with dementia in the South of England. The consultation took place between June and August 2013. The interviews and focus groups were audio recorded, transcribed verbatim. The transcripts were analysed thematically.

Findings
Benefits of extra care were identified as the opportunity for couples to remain living together for longer, creating a supportive, dementia-friendly community, and a reduction in the strain experienced by the care partners. Barriers centred on a sense of loss, stress and uncertainty. Living and caring at home was perceived as preferable to shared care.

Research limitations/implications
The findings presented here have limited generalisability for two reasons. First, the shared care approach consulted on was very specific. Second, the participants form a purposive sample and as such are not representative of a wider population. Despite best intentions, the voice of people with dementia, are underreported in this consultation. Only one person with early on-set dementia was interviewed and the remaining two people with dementia were interviewed alongside their care partner.

Practical implications
The findings cast doubt on the viability of extra care facilities, designed for couples living with dementia, if extra care continues to be conceptualised and marketed as a preventative lifestyle choice. The findings indicate the value of consulting with people with dementia, and their care partners, when designing new forms of housing with care specifically for people living with dementia.

Social implications
The findings of this consultation exemplify the wish of couples living with dementia to remain together, in what they perceive to be “home”, for as long as possible. Couples living with dementia are therefore unlikely to wish to move into an extra care facility as a lifestyle choice option, early into their journey with dementia. This raises questions about the suitability of extra care, as a form of housing with care, for couples living with dementia.

Originality/value
This paper contributes to the body of literature, exploring the feasibility of new and innovative alternative care and housing options, for people with dementia. This paper is one of the first to explore extra care as a housing and social care option for couples with dementia.
Outliers in data envelopment analysis
Authors: Boyd Taylor , Docken Grace , Ruggiero John 
Published: April 2017

Purpose
The purpose of this paper is to improve the estimation of the production frontier in cases where outliers exist. We focus on the case when outliers appear above the true frontier due to measurement error.

Design/methodology/approach
The authors use stochastic data envelopment analysis (SDEA) to allow observed points above the frontier. They supplement SDEA with assumptions on the efficiency and show that the true frontier in the presence of outliers can be derived.

Findings
This paper finds that the authors’ maximum likelihood approach outperforms super-efficiency measures. Using simulations, this paper shows that SDEA is a useful model for outlier detection.

Originality/value
The model developed in this paper is original; the authors add distributional assumptions to derive the optimal quantile with SDEA to remove outliers. The authors believe that the value of the paper will lead to many citations because real-world data are often subject to outliers.
Factors affecting consumer acquisition of secondhand clothing in the USA
Authors: Norum Pamela , Norton Marjorie 
Published: April 2017

Purpose
The purpose of this paper is to explore factors affecting secondhand clothing acquisition among a sample of US female consumers based on an economic perspective.

Design/methodology/approach
This research is descriptive in nature, utilizing a survey of 500 US female consumers to explore relationships between five modes of secondhand clothing acquisition and selected consumer characteristics. Logistic regression was used to analyze the data.

Findings
The significant variables were income, age, number of toddlers and children ages 6-17 present in households, and sewing and repair skills. Income was found to be negatively related to purchasing secondhand clothing, suggesting that consumers view used clothing as an inferior good. Consumers in Gen Y were more likely to be involved in various means of secondhand clothing acquisition, holding income constant, than Baby Boomers.

Practical implications
Overcoming the stigma of inferiority associated with secondhand clothing, encouraging repair skills, and the repair of clothing, reaching out to consumers to build on their interest in DIY projects, and utilizing new technology (e.g. apps for sharing clothes) are practical implications.

Originality/value
The paper examined multiple modes of clothing acquisition rather than a single mode, and contributes insight regarding the economic concept of secondhand clothing as an inferior good.
The effect of shift work on the diet of accident and emergency nurses at a general hospital in Malta
Authors: Seychell Jesmond , Reeves Sue 
Published: April 2017

Purpose
The purpose of this paper was to investigate the effect of shift work on diet and lifestyle in nurses working in the accident and emergency department in a general hospital in Malta.

Design/methodology/approach
This study was a cross-sectional, quantitative survey, whereby data were collected by the use of anonymous questionnaires consisting of a demographic and anthropometric questionnaire, a lifestyle questionnaire and a food frequency questionnaire to assess dietary intakes. In total, 110 nurses completed the study and were divided into three groups: day nurses, rotating-shift nurses and night-shift nurses.

Findings
Shift working nurses consumed significantly more energy compared to day nurses (night-shift nurses 1,963 ± 506 kcal; rotating-shift nurses 2,065 ± 655 kcal; day nurses 1,722 ± 486 kcal; p = 0.04). Shift working nurses also consumed more protein (p = 0.04), fat (p = 0.047) and fibre (p = 0.005) compared to day nurses; however, day nurses were the most likely to smoke (p = 0.009).

Practical implications
Shift work does influence the diet of nurses in Malta. It is recommended that access to healthy food, and time and facilities for physical activity are made available across all working hours and that nurses aim to exercise regularly, eat healthily, quit smoking if necessary and get good-quality sleep where possible.

Originality/value
In total, 22 per cent of workers in Malta work shifts, and Malta currently has one of the highest rates of obesity in Europe. This study considers the impact of shift work on diet.
Nutrients intake in elderly residing in Lebanese nursing homes
Authors: Doumit Jacqueline , Nasser Ramzi 
Published: April 2017

PurposeThe purpose of this study was to assess nutrient intakes in elderly living in Lebanese nursing homes (NHs).Design/methodology/approachThis cross-sectional study was conducted in 36 long-term care institutions from all over Lebanon. Out of 2,094 residents, 98 (69 women and 29 men) elderly met the inclusion criteria and successfully completed the interview question. Dietary food intake was assessed using the 24-h food recall. The analysis used a Chi-square test and independent samplest-test or Mann–Whitney test, as appropriate.FindingsA high percentage of elderly (reaching 100 per cent) had a low intake of energy, protein, linolenic acid, linoleic acid, fibers, vitamins and minerals, and the prevalence of nutrient inadequacy was significantly different between sexes for copper intake (p= 0.02). The results of this study highlight the nutrient inadequacies among the majority of elderly living in long-term care institutions and particularly in women and elderly residing in NHs located away from the capital Beirut.Originality/valueThis study is quite original; this is the first study performed nationwide in Lebanon covering not only the largest number of NHs in various locations but also elderly under custodial settings and with diverse backgrounds.
Geometric size effect on IMC growth and elements diffusion in Cu/Sn/Cu solder joints
Authors: Zhu Yan , Sun Fenglian 
Published: April 2017

Purpose
The purpose of this paper is to investigate the effect of geometric size on intermetallic compound (IMC) growth and elements diffusion of Cu/Sn/Cu solder joint and establish the correlation model between the thickness of the IMC layer and size of the solder joint on the dozens of microns scale.

Design/methodology/approach
The sandwich-structured Cu/Sn/Cu solder joints with different gaps between two copper-clad plates (δ) are fabricated using a reflow process. The microstructure and composition of solder joints are observed and analyzed by scanning electron microscopy.

Findings
After reflow, the thickness of the IMC and Cu concentration in solder layers increase with the reduction of δ from 50, 40, 30, 20 to 10 μm. During isothermal aging, the thickness of the IMC fails to increase according to the traditional parabolic rule due to changes in Cu concentration. The reduction of δ is the root cause of changes in Cu concentration and the growth rule of the IMC layer. A correlation model between the thickness of the IMC layer and δ is established. It is found that the thickness of the IMC layer is the function of aging time and δ. With δ reducing, the main control element of IMC growth transfers from Cu to Sn.

Originality/value
This paper shows the changes of IMC thickness and elements concentration with the reduction of the size of solder joints on the dozens of microns scale. A correlation model is established to calculate the thickness of the IMC layer during aging.
Accuracy and Reliability of the Klales et al. (2012) Morphoscopic Pelvic Sexing Method
Authors: Lesciotto Kate M. , Doershuk Lily J. 
Published: April 2017

AbstractKlales et al. (2012) devised an ordinal scoring system for the morphoscopic pelvic traits described by Phenice (1969) and used for sex estimation of skeletal remains. The aim of this study was to test the accuracy and reliability of the Klales method using a large sample from the Hamann‐Todd collection (n = 279). Two observers were blinded to sex, ancestry, and age and used the Klales et al. method to estimate the sex of each individual. Sex was correctly estimated for females with over 95% accuracy; however, the male allocation accuracy was approximately 50%. Weighted Cohen's kappa and intraclass correlation coefficient analysis for evaluating intra‐ and interobserver error showed moderate to substantial agreement for all traits. Although each trait can be reliably scored using the Klales method, low accuracy rates and high sex bias indicate better trait descriptions and visual guides are necessary to more accurately reflect the range of morphological variation.
Prenatal and adult androgen activities in alcohol dependence
Authors: Lenz B. , Mühle C. , Braun B. , Weinland C. , Bouna‐Pyrrou P. , Behrens J. , Kubis S. , Mikolaiczik K. , Muschler M.‐R. , Saigali S. , Sibach M. , Tanovska P. , Huber S. E. , Hoppe U. , Eichler A. , Heinrich H. , Moll G. H. , Engel A. , Goecke T. W. , Beckmann M. W. , Fasching P. A. , Müller C. P. , Kornhuber J. 
Published: April 2017

ObjectiveAlcohol dependence is more prevalent in men than in women. The evidence for how prenatal and adult androgens influence alcohol dependence is limited. We investigated the effects of prenatal and adult androgen activity on alcohol dependence. Moreover, we studied how the behaviours of pregnant women affect their children's prenatal androgen load.MethodWe quantified prenatal androgen markers (e.g., second‐to‐fourth finger length ratio [2D : 4D]) and blood androgens in 200 early‐abstinent alcohol‐dependent in‐patients and 240 controls (2013–2015, including a 12‐month follow‐up). We also surveyed 134 women during pregnancy (2005–2007) and measured the 2D : 4D of their children (2013–2016).ResultsThe prenatal androgen loads were higher in the male alcohol‐dependent patients compared to the controls (lower 2D : 4D, P = 0.004) and correlated positively with the patients’ liver transaminase activities (P < 0.001) and alcohol withdrawal severity (P = 0.019). Higher prenatal androgen loads and increasing androgen levels during withdrawal predicted earlier and more frequent 12‐month hospital readmission in alcohol‐dependent patients (P < 0.005). Moreover, stress levels (P = 0.002), alcohol (P = 0.010) and tobacco consumption (P = 0.017), and lifetime stressors (P = 0.019) of women during pregnancy related positively to their children's prenatal androgen loads (lower 2D : 4D).ConclusionAndrogen activities in alcohol‐dependent patients and behaviours of pregnant women represent novel preventive and therapeutic targets of alcohol dependence.
Systematic review indicates postnatal growth in term infants born small‐for‐gestational‐age being associated with later neurocognitive and metabolic outcomes
Authors: Castanys‐Muñoz Esther , Kennedy Kathy , Castañeda‐Gutiérrez Eurídice , Forsyth Stewart , Godfrey Keith M. , Koletzko Berthold , Ozanne Susan E. , Rueda Ricardo , Schoemaker Marieke , van der Beek Eline M. , van Buuren Stef , Ong Ken K. 
Published: April 2017

AbstractWe systematically reviewed papers published in English between 1994 and October 2015 on how postnatal weight gain and growth affect neurodevelopment and metabolic outcomes in term‐born small‐for‐gestational‐age (SGA) infants. Two randomised trials reported that enriched infant formulas that promoted early growth also increased fat mass, lean mass and blood pressure (BP), but had no effect on early neurocognitive outcomes. Meanwhile, 31 observational studies reported consistent positive associations between postnatal weight gain and growth with neurocognitive outcomes, adiposity, insulin resistance and BP.Conclusion: Few intervention studies exist, despite consistent positive associations between early growth and neurocognition in term‐born SGA infants.