bluuebunny/crossref_metadata_2025_split huggingface dataset:
Skin depigmentation associated with toceranib phosphate in a dog
Authors: Cavalcanti Jacqueline V. J. , Hasbach Andrea , Barnes Katie , Dange Rahul B. , Patterson Jon , Saavedra Paulo Vilar 
Published: February 2017

BackgroundDrug‐induced depigmentation is frequently observed in humans undergoing tyrosine kinase inhibitor therapy, whereas it is not reported in dogs. The skin depigmentation can occur after the first week of treatment and it is reversible within a few weeks after drug discontinuation.ObjectivesTo report the clinical and histopathological features of an episode of cutaneous adverse drug reaction associated with short term administration of toceranib phosphate.Case reportAn 11‐year‐old intact male Bernese mountain dog was presented for investigation of a subcutaneous mast cell tumour (MCT) including treatment options. The major abnormality on physical examination was a 7.5 × 10 cm subcutaneous mass located cranial to the left shoulder joint consistent with a MCT. Toceranib phosphate therapy was initiated. Fourteen days after initiating treatment, the dog presented with skin erosions near the lateral canthus of the left eye. Three weeks later there were multiple skin lesions characterized by alopecia and depigmentation involving left and right eyelids; leukotrichia of the periorbital areas and depigmentation of the nasal planum and all paw pads. Histopathological findings were nonspecific; they were supportive of vitiligo. Resolution of skin lesions was observed after stopping the toceranib phosphate therapy.Conclusion and clinical importanceBased on the gross lesions, histopathological features before and after tyrosine kinase inhibitor therapy, and Naranjo score, this case was considered to be consistent with cutaneous adverse drug effects. To the best of the authors’ knowledge, this is the first report describing the clinical and histopathological features of presumed drug‐induced skin depigmentation in a dog receiving toceranib phosphate.
Reference values for rotational thromboelastometry (ROTEM) in clinically healthy cats
Authors: Marly‐Voquer Charlotte , Riond Barbara , Jud Schefer Rahel , Kutter Annette P. N. 
Published: February 2017

AbstractObjectiveTo establish reference intervals for rotational thromboelastometry (ROTEM) using feline blood.DesignProspective study.SettingUniversity teaching hospital.AnimalsTwenty‐three clinically healthy cats between 1 and 15 years.InterventionFor each cat, whole blood was collected via jugular or medial saphenous venipuncture, and blood was placed into a serum tube, a tube containing potassium‐EDTA, and tubes containing 3.2% sodium citrate. The tubes were maintained at 37°C for a maximum of 30 minutes before coagulation testing.Measurements and Main ResultsROTEM tests included the EXTEM, INTEM, FIBTEM, and APTEM assays. In addition, prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen concentration (Clauss method) were analyzed for each cat. Reference intervals for ROTEM were calculated using the 2.5–97.5th percentile for each parameter, and correlation with the standard coagulation profile was performed. Compared to people, clinically healthy cats had similar values for the EXTEM and INTEM assays, but had lower plasma fibrinogen concentrations (0.9–2.2 g/L), resulting in weaker maximum clot firmness (MCF, 3–10 mm) in the FIBTEM test. In 18 cats, maximum lysis (ML) values in the APTEM test were higher than in the EXTEM test, which seems unlikely to have occurred in the presence of aprotinin. It is possible that the observed high maximum lysis values were due to clot retraction rather than true clot lysis. Further studies will be required to test this hypothesis.ConclusionsCats have a weaker clot in the FIBTEM test, but have a similar clot strength to human blood in the other ROTEM assays, which may be due to a stronger contribution of platelets compared to that found in people. In cats, careful interpretation of the results to diagnose hyperfibrinolysis is advised, especially with the APTEM test, until further data are available.
Finnish botanists and mycologists in the Arctic
Authors: Väre Henry 
Published: February 2017

Finnish botanists and mycologists have studied Arctic areas and timberline regions since the beginning of the 18th century. Most expeditions to the Kola Peninsula were made between 1800 and 1917 and until 1945 to Lapponia petsamoënsis on the western rim of the Kola Peninsula. Since those years, these areas have been part of the Soviet Union or Russia. Svalbard and Newfoundland and Labrador have been studied repeatedly as well, Svalbard since the 1860s and Newfoundland and Labrador since the 1930s. This article focuses on Finnish collections. These are deposited in the herbaria of Helsinki, Turku, and Oulu universities, except materials from the Nordenskiöld expeditions, which were mainly deposited in Stockholm. Concerning the Kola Peninsula, collections at Helsinki are the most extensive. The exact number of specimens is not known, but by rough estimation, the number is about 60 000, with an additional 110 000 observations included in the database. These expeditions have provided material to describe 305 new taxa to science, viz. 47 algae, 78 bryophytes, 25 fungi, 136 lichens, and 19 vascular plants. This number is an underestimate, as many new species have been described in several separate taxonomic articles. At least 63 persons have contributed to making these collections to Finnish herbaria. Of those, 52 are of Finnish nationality.
ВІДМІННОСТІ ПРОЯВІВ ДЕПРЕСИВНИХ РОЗЛАДІВ У ЕМІГРАНТІВ З УРАХУВАННЯМ ГЕНЕЗУ ПАТОЛОГІЇ (ПСИХОГЕННОГО, ЕНДОГЕННОГО, ОРГАНІЧНОГО)
Authors: Venger O. P. 
Published: February 2017

Проведене дослідження соціально-психологічних, феноменологічних, клініко-психопатологічних відмінностей депресивних розладів у емігрантів з урахуванням ґенезу патології органічного, ендогенного та психогенного характеру. Використано клініко-психопатологічний, психометричний, статистичний методи. Нами обстежено 198 емігрантів (осіб, які постійно, щонайменше протягом останнього року, проживали за межами України і на момент обстеження тимчасово перебували в Україні та планували найближчим часом повернутися за кордон) яким встановлено остаточний клінічний діагноз депресивного розладу відповідно до критеріїв МКХ-10. Ми виділили три клінічні групи емігрантів, хворих на психогенні депресивні розлади, ендогенні та органічні. Психометричне дослідження виявило у емігрантів, хворих на депресивні розлади, виражені ознаки депресивного настрою; їм притаманні прояви адинамічної, ажитованої депресії та депресії зі страхом, причому найважчими ці прояви є у хворих на органічні та ендогенні депресії. Високий рівень депресії поєднується у емігрантів з вираженими ознаками тривоги, як психічної, так і соматичної; ці прояви також найбільш виражені у емігрантів, хворих на органічні та ендогенні депресивні розлади. Суїцидальні спроби найрідше скоювали емігранти, хворі на психогенну депресію (2,9 %). Оцінка суїцидального ризику виявила, що емігрантам притаманний суїцидальний ризик середнього ступеня.
ДЕЯКІ ВЛАСТИВОСТІ ГЕКСАФТОРОСИЛІКАТІВ 3,5-ДИЗАМІЩЕНИХ ПОХІДНИХ 1,2,4-ТРИАЗОЛУ
Authors: Shyshkin I. O. , Anisimov V. Yu. , Gelmboldt V. O. 
Published: February 2017

З використанням методу фотоколориметрії проведено визначення ступеня гідролізу гексафторосилікатів 3,5-дизаміщених похідних 1,2,4-триазолу в 1×10-4 М водних розчинах їх солей. Встановлено, що ступінь гідролізу солей змінюється в межах 63,8 – 92,0 %. Знайдено розчинність їх солей у воді, яка становить ≤ 0,0002 мол. %.
An Overview of Drought Monitoring and Prediction Systems at Regional and Global Scales
Authors: Hao Zengchao , Yuan Xing , Xia Youlong , Hao Fanghua , Singh Vijay P. 
Published: February 2017

AbstractIn past decades, severe drought events have struck different regions around the world, leading to huge losses to a wide array of environmental and societal sectors. Because of wide impacts of drought, it is of critical importance to monitor drought in near–real time and provide early warning. This article provides an overview of the development of drought monitoring and prediction systems (DMAPS) at regional and global scales. After introducing drought indicators, drought monitoring (based on different data sources and tools) is summarized, along with an introduction of statistical and dynamical drought prediction approaches. The current progress of the development and implementation of DMAPS with various indicators at different temporal and/or spatial resolutions, based on the land surface modeling, remote sensing, and seasonal climate forecast, at the regional and global scales is then reviewed. Advances in drought monitoring with multiple data sources and tools and prediction from multimodel ensembles are highlighted. Also highlighted are challenges and opportunities, including near-real-time and long-term data products, indicator linkage to impacts, prediction skill improvement, and information dissemination/communication. The review of different components of these systems will provide useful guidelines and insights for the future development of effective DMAPS to aid drought modeling and management.
Comment on “Using an ADCP to Estimate Turbulent Kinetic Energy Dissipation Rate in Sheltered Coastal Waters”
Authors: Gargett Ann E. 
Published: February 2017

AbstractGreene et al. revisit the suggestion that the turbulent kinetic energy dissipation rate could be estimated through a “large-eddy estimate,” employing acoustic measurements of velocity fields associated with the largest energy-containing scales of ocean turbulence. While the large-eddy estimate as originally proposed used vertical velocity and a vertical eddy length scale, Greene et al. chose instead to substitute a horizontal length scale for the latter. This comment argues that combining a horizontal scale for length with a vertical velocity scale produces a large-eddy estimate of the dissipation rate that is accurate only if the energy-containing eddies are isotropic, and that this condition is highly unlikely in naturally occurring ocean turbulence, subject as it is to influences of stratification, vertical shear, and/or the presence of horizontal boundaries. The problem is documented using data from a large-eddy simulation of Langmuir supercells.
Relationship of depression with cognitive insight and socio-occupational outcome in patients with schizophrenia
Authors: Grover Sandeep , Sahoo Swapnajeet , Nehra Ritu , Chakrabarti Subho , Avasthi Ajit 
Published: February 2017

Aim: To evaluate the prevalence of depression using different measures in patients with schizophrenia and to study the relationship of depression in schizophrenia with cognitive insight and clinical insight, disability and socio-occupational functioning. Methods: A total of 136 patients with schizophrenia were evaluated for depression, cognitive insight and socio-occupational functioning. Results: Of the 136 patients included in the study, one-fourth ( N = 34; 25%) were found to have depression as per the Mini International Neuropsychiatric Interview (MINI). The prevalence of depression as assessed by Calgary Depression Scale for Schizophrenia (CDSS), Hamilton depression rating scale (HDRS) and Depressive Subscale of Positive and Negative Syndrome Scale (PANSS-D) was 23.5%, 19.9% and 91.9%, respectively. Among the different scales, CDSS has highest concordance with clinician’s diagnosis. Sensitivity, specificity, positive predictive value and negative predictive value for CDSS was also higher than that noted for HDRS and PANSS-D. When those with and without depression as per clinician’s diagnosis were compared, those with depression were found to have significantly higher scores on Positive and Negative Syndrome Scale (PANSS) positive and general psychopathology subscales, PANSS total score, participation restriction as assessed by P-scale and had lower level of functioning as assessed by Global Assessment of Functioning (GAF). No significant difference was noted on negative symptom subscale of PANSS, clinical insight as assessed on G-12 item of PANSS, disability as assessed by Indian Disability Evaluation and Assessment Scale (IDEAS) and socio-occupational functioning as assessed by Social and Occupational Functioning Assessment Scale (SOFS). In terms of cognitive insight, those with depression had significantly higher score for both the subscales, that is, self-reflective and self-certainty subscales as well as the mean composite index score. Conclusion: Our results suggest that one-fourth of patients with schizophrenia have depression, compared to HDRS and PANSS-D, CDSS has highest concordance with clinician’s diagnosis of depression and presence of depression is related to cognitive insight.
Improved fat-suppression homogeneity with mDIXON turbo spin echo (TSE) in pediatric spine imaging at 3.0 T
Authors: Pokorney Amber L , Chia Jonathan M , Pfeifer Cory M , Miller Jeffrey H , Hu Houchun H 
Published: February 2017

Background Robust fat suppression remains essential in clinical MRI to improve tissue signal contrast, minimize fat-related artifacts, and enhance image quality. Purpose To compare fat suppression between mDIXON turbo spin echo (TSE) and conventional frequency-selective and inversion-recovery methods in pediatric spine MRI. Material and Methods Images from T1-weighted (T1W) and T2-weighted (T2W) TSE sequences coupled with conventional methods and the mDIXON technique were compared in 36 patients (5.8 ± 5.4 years) at 3.0 T. Images from 42 pairs of T1W (n = 16) and T2W (n = 26) scans were acquired. Two radiologists reviewed the data and rated images using a three-point scale in two categories, including the uniformity of fat suppression and overall diagnostic image quality. The Wilcoxon rank-sum test was used to compare the scores. Results The Cohen’s kappa coefficient for inter-rater agreement was 0.69 (95% confidence interval [CI], 0.56–0.83). Images from mDIXON TSE were considered superior in fat suppression ( P < 0.01) in 22 (rater 1) and 25 (rater 2) cases, respectively. In 13 (rater 1) and 11 (rater 2) cases, mDIXON TSE demonstrated improved diagnostic image quality ( P < 0.01). In three cases, fat suppression was superior using inversion-recovery and likewise in one case mDIXON had poorer image diagnostic quality. Lastly, mDIXON and conventional fat-suppression methods performed similarly in 17 (rater 1) and 14 (rater 2) cases, and yielded equal diagnostic image quality in 28 (rater 1) and 30 (rater 2) cases. Conclusion Robust fat suppression can be achieved with mDixon TSE pediatric spine imaging at 3.0 T and should be considered as a permanent replacement of traditional methods, in particular frequency-selective techniques.
An efficient extended target detection method based on region growing and contour tracking algorithm
Authors: Yan Bo , Xu LP , Yan JZH , Li Cong 
Published: February 2017

Extended target detection in the presence of K-distributed clutter has gained a special interest in recent years. High-resolution radars allow a target to be found in several resolution cells. Therefore, the detection rate and the false alarm rate of an extended target should be analyzed by these cells jointly rather than in one single resolution cell. A detector in which all the cells whose magnitude affected by one target are considered jointly is present. The performance and optimal parameters of the detector are analyzed in detail. Meanwhile, the large amount of calculation caused by enormous raw data is also considered. Then, an efficient method based on region growing algorithm and contour tracking algorithm is proposed. Only part of the resolution cells is scanned once with the proposed method, while all the cells are scanned at least one times in the existing methods. Therefore, considerable calculations are saved. Furthermore, the proposed method and several existing methods are performed with real data and simulated data, and the results show that the proposed model is practical and efficient to detect the extended targets in K-distributed clutters.
Infodemiology of systemic lupus erythematous using Google Trends
Authors: Radin M , Sciascia S 
Published: February 2017

Objective People affected by chronic rheumatic conditions, such as systemic lupus erythematosus (SLE), frequently rely on the Internet and search engines to look for terms related to their disease and its possible causes, symptoms and treatments. ‘Infodemiology’ and ‘infoveillance’ are two recent terms created to describe a new developing approach for public health, based on Big Data monitoring and data mining. In this study, we aim to investigate trends of Internet research linked to SLE and symptoms associated with the disease, applying a Big Data monitoring approach. Methods We analysed the large amount of data generated by Google Trends, considering ‘lupus’, ‘relapse’ and ‘fatigue’ in a 10-year web-based research. Google Trends automatically normalized data for the overall number of searches, and presented them as relative search volumes, in order to compare variations of different search terms across regions and periods. The Menn–Kendall test was used to evaluate the overall seasonal trend of each search term and possible correlation between search terms. Results We observed a seasonality for Google search volumes for lupus-related terms. In the Northern hemisphere, relative search volumes for ‘lupus’ were correlated with ‘relapse’ (τ = 0.85; p = 0.019) and with fatigue (τ = 0.82; p = 0.003), whereas in the Southern hemisphere we observed a significant correlation between ‘fatigue’ and ‘relapse’ (τ = 0.85; p = 0.018). Similarly, a significant correlation between ‘fatigue’ and ‘relapse’ (τ = 0.70; p < 0.001) was seen also in the Northern hemisphere. Conclusion Despite the intrinsic limitations of this approach, Internet-acquired data might represent a real-time surveillance tool and an alert for healthcare systems in order to plan the most appropriate resources in specific moments with higher disease burden.
Cutpoints for screening blood glucose concentrations in healthy senior cats
Authors: Reeve-Johnson Mia K , Rand Jacquie S , Vankan Dianne , Anderson Stephen T , Marshall Rhett , Morton John M 
Published: February 2017

Objectives The objectives of this study were to determine the reference interval for screening blood glucose in senior cats, to apply this to a population of obese senior cats, to compare screening and fasting blood glucose, to assess whether screening blood glucose is predicted by breed, body weight, body condition score (BCS), behaviour score, fasting blood glucose and/or recent carbohydrate intake and to assess its robustness to changes in methodology. Methods The study included a total of 120 clinically healthy client-owned cats aged 8 years and older of varying breeds and BCSs. Blood glucose was measured at the beginning of the consultation from an ear/paw sample using a portable glucose meter calibrated for cats, and again after physical examination from a jugular sample. Fasting blood glucose was measured after overnight hospitalisation and fasting for 18–24 h. Results The reference interval upper limit for screening blood glucose was 189 mg/dl (10.5 mmol/l). Mean screening blood glucose was greater than mean fasting glucose. Breed, body weight, BCS, behaviour score, fasting blood glucose concentration and amount of carbohydrate consumed 2–24 h before sampling collectively explained only a small proportion of the variability in screening blood glucose. Conclusions and relevance Screening blood glucose measurement represents a simple test, and cats with values from 117–189 mg/dl (6.5–10.5 mmol/l) should be retested several hours later. Cats with initial screening blood glucose >189 mg/dl (10.5 mmol/l), or a second screening blood glucose >116 mg/dl (6.4 mmol/l) several hours after the first, should have fasting glucose and glucose tolerance measured after overnight hospitalisation.
Can an operative coding sticker improve coding accuracy and remuneration for upper tract stone-related procedures?
Authors: Bedi Nishant , Greenham Olivia E , Inglis John A , Rukin Nicholas J 
Published: February 2017

Objective: Rigid ureteroscopy, flexible uretero-renoscopy and ureteric stenting are commonly performed procedures. Operative clinical coding and remuneration varies depending on the procedure. We determined if loss of remuneration, through poor operative coding, could be improved with an operative coding sticker. Patients and methods: We performed a retrospective review of 133 random stone-related procedures (rigid ureteroscopy/flexible uretero-renoscopy and ureteric stenting). Using the Office of Population Censuses and Surveys codes, we compared actual operative coding and urological surgeon coding. We introduced an operative coding sticker and prospectively re-audited to determine if coding accuracy improved. Results: Flexible uretero-renoscopy was initially miscoded in 29 of 53 cases (55%), with a loss of remuneration of £1014 per case. Rigid ureteroscopies were correctly coded in 99% of cases, but ureteric stenting was only correctly coded in 82%. The introduction of the coding sticker resulted in improved coding accuracy rates of 100% for rigid ureteroscopy, 95% for flexible uretero-renoscopy and 100% for ureteric stenting. Overall, coding accuracy improved from 54% to 99%. We estimate this coding sticker will improve our departmental remuneration by £67,938 per year. Conclusion: Rigid ureteroscopy, flexible uretero-renoscopy and ureteric stenting were initially poorly coded. The introduction of a simple operative coding sticker improved coding compliance to 99% and increased operative remuneration.
Validation of selective use of intraoperative PTH monitoring in parathyroidectomy
Authors: Thielmann Alexandra , Kerr Paul 
Published: February 2017

Background The objective of this study was to validate our approach of treating primary hyperparathyroidism using sestamibi scan directed parathyroidectomy, without routine use of intraoperative parathyroid hormone measurements (ioPTH). Methods We prospectively established a protocol limiting the use of ioPTH to patients with negative or equivocal sestamibi scans, and those who had risk factors for multi-gland disease. We then performed a retrospective review to determine our disease control rate. Results 128 patients underwent sestamibi-guided parathyroidectomy without (111/128 = 87%) or with (17/128 = 13%) ioPTH. The overall disease control (eucalcemia) rate was 95%. 3/111 (3%) of patients who had surgery without ioPTH measurements required re-exploration. Conclusions Selective use of ioPTH is an effective strategy. ioPTH is best reserved for patients who have non-localizing preoperative imaging, are at risk for multi-gland disease, or require revision surgery.