bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surveillance of Antibiotic Resistant Klebsiella pneumoniae in Tertiary Care Hospital of Nepal
Authors: Amatya Niroj Man , Shrestha Sanjit , Dangal Laxmi , Paudel Aarati , Banjara Sanju , Chaudhary Sweta 
Published: October 2024

Background Klebsiella pneumoniae is a ubiquitous Gram-negative, non-motile, encapsulated bacterium that resides in the mucosal surfaces of mammals and the environment such as soil, water, etc. Clinically, it is also associated with many infections and conditions that are aggravated by the acquisition of multidrug-resistant genes. MethodsThis descriptive study was conducted to find out the incidence of Klebsiella pneumoniae in different clinical samples and their antibiotic susceptibility pattern at B & B Hospital, Lalitpur from 12 June 2022 to 11 September 2022. The samples were cultured on MacConkey agar, and standard microbiological techniques were used to confirm the presence of K. pneumoniae. Antimicrobial susceptibility tests were performed using the Kirby-Bauer Disk Diffusion method.ResultsOf the 1967 different clinical samples, culture positivity was observed in 361 samples. Among these, total number of Klebsiella pneumoniae was 150 (41.55%) and from the urine samples exclusively, 63 (42%) Klebsiella pneumoniae were isolated. The most susceptible and resistant antibiotics were gentamicin and ciprofloxacin respectively. Among the isolates, 85 (56.66%) isolates were multi-drug resistant in which 69 (87.34%) isolates were resistant to carbapenem.Conclusions The diversified infections with a growing number of multi-drug resistant Klebsiella pneumoniae present a major public health concern. The limited availability of effective antibiotics emphasizes the prudent use of available antibiotics and the importance of regular national-wide surveillance of multi-drug resistance patterns.
Neuroimaging markers of phenomena of perceived stigmatization in people with and without mental disorders: a systematic scoping-review
Authors: Lutova Natalia B. , Khobeysh Maria A. , Gerasimchuk Ekaterina S. , Bocharova Maria O. , Makarevich Olga V. , Sorokin Mikhail Yu. 
Published: October 2024

Summary. Along with traditional research on psychiatric stigma, there has recently been increasing interest in the neurobiological factors associated with stigmatization.Aim: to study the most common research methods in the studies of the neurobiological correlates of stigmatization phenomenon and its components, as well as to systematize their results, taking into account their methodological limitations.Materials and Methods: The review was conducted in accordance with the PRISMA-ScR extension. Studies were searched in MEDLINE, EMBASE, PsycINFO using the Ovid platform. After evaluating 2358 articles according to inclusion, non-inclusion, and exclusion criteria, 20 articles were included in the final analysis.Results: The most of the studies were conducted on samples of healthy respondents without a control group (14 articles). The mean age of respondents ranged from 18.8 [1.0] to 42.7 [14.7] years. Psychiatric stigma was studied in 2 studies; in the remaining articles, various components of stigma were studied, among which social rejection sensitivity was most often studied (13 articles). Among fMRI paradigm the Cyberball social exclusion task was used more often (10 articles). Changes in neural activity, correlating with the severity of stigma and its constituent constructs, were found in the anterior cingulate cortex, prefrontal cortex, insula, thalamus, hypothalamus, hippocampus, parahippocampal gyrus, ventral region of the striatum, putamen, amygdala.Conclusion: Functional magnetic resonance studies can be an effective tool for verifying and assessing the dynamics of the psychological state of people experiencing the phenomenon of stigmatization.
“V.M. Bekhterev Review of Psychiatry and Medical Psychology” — History of the First Psychiatric Journal in Russia
Authors: Popov Yuri V. , Neznanov Nikolay G. 
Published: October 2024

The article presents the historical facts oт the creation of the first psychiatric journal in Russia (1896). The organizer of the journal and its first editor-in-chief was V.M. Bekhterev. After his death in 1927, the journal was named after him. It had been published until its closure in 1930. For various reasons, some of which are discussed in the article, the journal has not been published for six decades. The organizational difficulties of registering printed materials that existed at that time are also described. Nevertheless, they were overcome, and in 1990 the USSR State Press Committee issued the Order «On the resumption of publication of the journal...». The journal received a Registration Certificate and was assigned to almost the highest group of central journals. All financing was assigned to the Leningrad branch of the publishing house «Medicine», and the journal was printed in the fabulous in modern reality figure of 20,000 copies per month.After the collapse of the USSR in 1991, this Order ceased to be valid, and the whole thing had to be started all over again. Nevertheless, the first issue of the journal was published in 1991. Its release has been expected not only in Russia, but also abroad. The first issue included a welcoming speech by the President of the World Psychiatric Association, Jorge Alberto Costa e Silva, which attracted even more attention towards the journal. In 1992, the American Psychiatric Association published an English-language digest of the journal in the United States. For some time the journal was also published in Paris (1998-2000) and in Moscow (2004-2011). Currently, the journal is published by its founder, the V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology in St. Petersburg and is one of the most renowned journals in the field of psychiatry and medical psychology in Russia.
Diagnostic Values of Ki67, Cox2, CD31, E-cadherin, VEGF, MMP2, and MMP9 Protein Expression in Human Melanoma
Authors: Karkhaneh Yousefi Nahid , Muhammadnejad Ahad , Rahmati Marveh , Ghanadan Alireza , Razavirad Amirhossein 
Published: October 2024

Background: Cutaneous melanoma, the most severe form of skin cancer, has an unpredictable behavior and a high mortality rate. Recent research has identified new biomarkers and their associations with certain histopathological features, offering essential insights into diagnosis, prognosis, and therapeutic strategies.
Material and method: In this meticulously designed and executed study, we analyzed 85 formalin-fixed, paraffin-embedded (FFPE) tissue samples using the gold standard technique of immunohistochemistry (IHC) to characterize the protein expression profiles. We used a comprehensive panel of Ki67, Cox2, CD31, VEGF, MMP2, MMP9, and E-cadherin antibodies. Clinical stages were meticulously determined according to TNM classification, the thickness of the Breslow depth, and Clark levels. We employed robust statistical methods such as one-way ANOVA and curve estimation regression to analyze the data. The STRING database, a trusted resource, was used to identify protein-protein interactions and related pathways.
Results: The results of our study unveiled novel pairwise positive correlations between CD31 and Ki67 (r = 0.72), and between VEGF and Ki67 protein expression (r = 0.63). We also found a significant inverse relationship between the expression of E-cadherin and some biomarkers, such as Ki67, CD31, and VEGF (p < 0.001 for all). Additionally, our findings revealed a strong positive association between the extent of tumor invasion and the expression levels of Ki67, CD31, and VEGF. The overexpression of these proteins was significantly correlated with advanced clinical stages (p < 0.001 for all).
Conclusion: Our study suggests that the biomarkers we examined could be reliable potential diagnostic and prognostic biomarkers for cutaneous melanoma. These findings have the potential to significantly impact the diagnosis, prognosis, and treatment of this deadly disease, offering new avenues for improved patient care.
Complications: skull base and cerebrovascular
Authors: Jean Walter C. , Charbel Fady T. , Cohen-Gadol Aaron A. , Couldwell William T. , Lawton Michael T. , McDermott Michael , Morcos Jacques J. , Spetzler Robert F. , van Loveren Harry R. , Benet Arnau , Catapano Joshua S. , Eberle Adam T. , Karadimas Spyridon K. , McGuire Laura Stone , Patrick Hayes H. , Rahmani Redi , Scherschinski Lea , Wu Eva M. 
Published: October 2024

Neurosurgical complications are a rich source for learning, but they are grossly underutilized for the purpose of surgeon education. Details of the complications, which make them all the more powerful as teaching tools, are restricted to morbidity and mortality conferences behind closed doors, and open discussions of the topic are blurred by hypotheticals in order to shield the presenters from medicolegal risks.
In this issue of Neurosurgical Focus, 9 neurosurgeons were invited to present complications they encountered along with the details and specific lessons they learned. The contributors were picked for their well-known track record of skill, experience, and candor, so readers can be confident in the lessons. The video and the accompanying written article present the clinical facts. The actions that led to the complications are demonstrated in the surgical video segments.
In ancient Western civilization, the seven "deadly sins" categorized and conceptualized human malfeasance, and similarly, the neurosurgical correlate of this set of sins can provide a framework for discussing the errors that lead to unexpectedly poor outcomes. Although errors in judgment and planning grow rarer with experience, errors in execution can still occur, no matter the stage of one’s career. Interestingly, even though skill and experience do not eliminate complications, they may affect the lesson that the neurosurgeon takes home.
The lack of open discourse on complications may slow progress in the field and set the stage for repeating mistakes. The writing and production teams hope that this work opens a rich source of learning.
The video can be found here: https://stream.cadmore.media/r10.3171/2024.7.FOCUS24379
ФОРМУВАННЯ ПРЕДМЕТНО-ПЕРЕТВОРЮВАЛЬНОЇ КОМПЕТЕНТНОСТІ УЧНІВ СТАРШИХ КЛАСІВ ПРИ ВИКОНАННІ РОБІТ НА УРОКАХ ТРУДОВОГО НАВЧАННЯ ЗА ДОПОМОГОЮ РУЧНОГО ЕЛЕКТРИФІКОВАНОГО ІНСТРУМЕНТУ
Authors: Пшеничний Максим , Цибулько Григорій 
Published: October 2024

Основною проблемою сучасних шкільних майстерень є фізичне і моральне старіння та зношення устаткування інструментів та обладнання, що випускалися раніше вітчизняною промисловістю для занять з трудового навчання та технології. У наш час запропонований електроінструмент виготовляють переважно в Китаї та інших країнах. Ручний електроінструмент став більш доступний для користувача недорогий але має невеликий електроресурс, запропоновані електроінструменти неможна довго навантажувати та перевантажувати. Пристосований цей інструмент, як правило, лише для забезпечення власних побутових потреб користувача. Тому школи вимушені самостійно вирішувати проблеми оснащення та переоснащення шкільних навчальних майстерень необхідним устаткуванням і інструментами. В той же час впровадження нового стандарту середньої освіти потребує змін змісту та форм навчання в галузі трудової освіти і виховання. Наведені вище дані дали можливість стверджувати: незважаючи на те, що основні вміння та навички експлуатації основних видів електроінструментів у здобувачів були сформовані в побутових умовах, деякі із перелічених вище інструментів вони розпочали використовувати тільки у ВНЗ (електрофрезер, електропила, електрорубанок та ін.) Згідно з положеннями Нової української школи, центральне місце в системі освіти належить середній школі та трудовому навчанню. На думку науковців на відміну від університету, в школі ще можна вирівняти дисбаланс у розвитку здобувачів закладів загальної середньої освіти. Формування та розвиток професійної особистості, неможливий без вмінь та навичок роботи ручним-електрифікованим інструментом Таким чином, підготовка учнів до безпечного життя та подальшої діяльності неможлива без опанування ручного електрифікованого інструменту в Новій українській школі, засвоєння сучасних знань з техніки безпеки та охорони праці, їх практичного застосування.
ОСОБЛИВОСТІ ВИКОРИСТАННЯ КОМП’ЮТЕРНИХ ТЕХНОЛОГІЙ В ТРУДОВОМУ НАВЧАННІ ТА ВИХОВАННІ УЧНІВ ЗАКЛАДУ ЗАГАЛЬНОЇ СЕРЕДНЬОЇ ОСВІТИ В УМОВАХ ДИСТАНЦІЙНОГО НАВЧАННЯ
Authors: Цибулько Григорій , Пшеничний Максим 
Published: October 2024

Використання комп’ютерних технологій в навчальному процесі дає можливість застосовувати в педагогічній практиці педагогічні розробки, які дозволяють інтенсифікувати навчальний процес, реалізувати ідеї розвиваючого трудового навчання. Нова Українська школа, крім навчання учнів конкретним знанням основ наук, повинна наділити уміннями і навичками в постійному самостійному поповненні своїх знань, створити підґрунтя для саморозвитку учнів. Одним зі шляхів досягнення зазначеної мети є послідовне використання комп'ютерних технологій у трудовому навчанні. Сучасний пошук нових шляхів оволодіння елементами комп’ютерної грамотності школярів, потребує глибокого психолого-педагогічного обґрунтування. Таким чином, нові інформаційні технології, які застосовуються методично грамотно під час реалізації методу проектів на уроках трудового навчання та технологій в загальноосвітній школі, підвищують пізнавальну активність учнів, що, поза сумнівом, приводить до підвищення ефективності навчання. Проте, на наш погляд, комп'ютер не може повністю замінити вчителя. У даний час в Україні склалася досить суперечлива ситуація: незважаючи на вказані позитивні фактори, комп’ютер на заняттях з трудового навчання, використовується лише при дистанційному навчанні, безсистемно і переважно з метою контролю знань, не торкаючи, як правило, інших етапів навчання.
ЖОЛ ИНФРАҚҰРЫЛЫМЫНЫҢ САПАСЫ МЕН ҚАУІПСІЗДІГІН АРТТЫРУ ҮШІН ПОЛИМЕР БИТУМЫН ПАЙДАЛАНУ ПЕРСПЕКТИВАСЫ
Authors: Калимолдина Лайла , Әбілқасова С.О. , Қожайсақова M.A. , Сырымова Ж.Р. , Сұлтанаева А.Ә. 
Published: October 2024

Республика аумағында көмірсутектердің едәуір қоры бар. Қою қоңыр мұнайды синтетикалық мұнайға өңдеудің технологиялық процесі және қою қоңыр мұнайды алудың экологиялық және оңтайлы әдістерін әзірлеу тек Қазақстанда ғана емес, бүкіл әлемде өзекті мәселе болып табылады.
Бүгінгі таңда көлік инфрақұрылымына жүктеменің артуына байланысты жол төсемдерінің сапасы мен қауіпсіздігін арттыратын ғылыми зерттеулер мен озық технологияларды енгізу маңызды болып табылады. Оларды шешу жолдарының бірі – жол құрылысында полимерлі қоспалары бар асфальтбетонды пайдалану. Алматы қаласында жүргізілген сынақтар бұл технологияның жарылуға, жарықшақтарға және климаттық әсерлерге төзімділігін қамтамасыз ететінін көрсетті.
Қазіргі уақытта битум жыныстарының органикалық бөлігін бейорганикалық компоненттердің, құмның, саздың, судың және газдың тығыз қоспасынан бөлудің көптеген әдістері белгілі. Сондықтан органикалық бөлікті бөлудің әрбір әдісі, мұнай битум жыныстарының минералды құрамының әртүрлі механизмі қарастырылған.
Бұл жұмыста битумның екі түрінің физикалық және химиялық қасиеттерін салыстырмалы бағалау болды: бастапқы битум (70/100 маркалы) және полимерлі битум (СБС маркалы). Зерттеу жұмысында полимермен битумды модификациялауда физикалық және химиялық қасиеттері зерттелді.
Зерттеу жұмысының мақсаты битумды байланыстырғыштардың физикалық қасиеттерін олардың химиялық құрамына негізделген айырмашылықтарын зерттеу болды. Бұл зерттеуде екі байланыстырғыш материалы таңдалды, бірақ олардың асфальттау дәрежесі әртүрлі болды.
Битумды материалдардың Фраас, сақина-шар әдісімен, пенетрация, реологиялық, физика-химиялық қасиеттері зерттелді. Инфрақызыл (ИК) спектрлерді бағалау арқылы байланыстырғыштар мен олардың фракцияларындағы функционалдық топтар сипатталды.
Зерттеу полимерлі битумының өнімділігі мен тұрақтылығын жақсартуға, қоспалардың мөлшерін оңтайландыруға және үнемді конструкцияларды жасауға бағытталған.
Бұл зерттеудің нәтижелері олардың химиясына негізделген байланыстырушы заттардың физикалық қасиеттеріндегі айырмашылықтарды түсіну үшін битумды байланыстырғыштарға арналған жаңа аналитикалық тәсілді құру үшін пайдаланылуы мүмкін.
SYNTHESIS AND PHYSICO-CHEMICAL PROPERTIES OF A NEW COMPLEX FERRITE
Authors: Madiyarova Altynai , Mataev M.M. , Patrin G.S. , Abdraimova M.R. , Nurbekova M.A. 
Published: October 2024

The article discusses the synthesis of new complex ferrite, radiographic and electron microscopic studies. The phase of complex ferrites was synthesized by the method of high-temperature sol-gel synthesis. For the first time, the structure of CrKFe2O5 Composite ferrite was studied by X-ray phase analysis and scanning electron microscope methods, the syngony type, elementary cell parameters, radiographic and pycnometric densities, and elemental analysis were determined. A comparative analysis of the relationship between the parameters of the Crystal cell of primary substances and the parameters of the obtained complex ferrite Crystal cell was carried out. Micro-samples were taken from different parts of the crystallite obtained through a scanning electron microscope, the elemental composition of the crystals was analyzed, and the general type of layer of the complex ferrite surface was demonstrated. As a result, the fact that the compound consists of two phases, the clarity of its construction was determined by the topography and chemical composition of the compound. As a result, it was found that the newly synthesized complex ferrite corresponds to the Formula CrKFe2O5. The particle size of the compounds formed is large (between 200 μm, 20.0 μm, 5.00 μm and 2.00 μm).
Global existence and blow-up of solutions for mixed local and nonlocal hyperbolic equations
Authors: Zhao Yanan , Zhang Binlin 
Published: October 2024

In this paper, we consider the following mixed local and nonlocal hyperbolic equation: u t t − Δ u + μ ( − Δ ) s u = | u | p − 2 u , in Ω × R + , u ( x , 0 ) = u 0 ( x ) , u t ( x , 0 ) = u 1 ( x ) , in Ω , u ( x , t ) = 0 , in ( R N ∖ Ω ) × R 0 + , where s ∈ ( 0 , 1 ), N > 2, p ∈ ( 2 , 2 s ∗ ], μ is a nonnegative real parameter, Ω ⊂ R N is a bounded domain with Lipschitz boundary ∂ Ω, Δ is the Laplace operator, ( − Δ ) s is the fractional Laplace operator. By combining the Galerkin approach with the modified potential well method, we obtain the global existence, vacuum isolating, and blow-up of solutions for the aforementioned problem, provided certain assumptions are fulfilled. Specifically, we study the existence of global solutions for the above problem in the cases of subcritical and critical initial energy levels, as well as the finite time blow-up of solutions. Then, we investigate the blow-up of solutions for the above problem in the case of supercritical initial energy level, as well as upper and lower bounds of blow-up time of solutions.
Polskie elementarze (podręczniki do nauki czytania ) z XVI i początku XVII w.
Authors: Siess-Krzyszkowski Stanisław 
Published: October 2024

Od XVI do XVIII, a w szkółkach parafialnych i wiejskich do XIX w. uczono czytania znaną od starożytności metodą sylabizowania zwaną też metodą alfabetyczną. Istotną część wszystkich podręczników stanowiły nauki katechizmowe – stąd ich jednoznaczny charakter konfesyjny. Dwa najstarsze znane polskie podręczniki do nauki czytania były przeznaczone dla wyznawców konfesji augsburskiej. Jednak jest bardzo prawdopodobne, że pierwsze polskie elementarze, zawierające nauki katechizmowe zgodne z doktryną katolicką, zaczęto drukować w latach 20. XVI w. W artykule omówiono wszystkie znane obecnie edycje podręczników do nauki czytania pisma polskiego wydane w XVI i XVII w.
"He was a European, an educated man". Foreign contacts of Professor Adam Schaff (1913-2006) based on provenance analysis of selected copies from his book collection
Authors: Jarzyńska Katarzyna 
Published: October 2024

The article presents the results of the research conducted on the topic “The private book collection of Professor Adam Schaff in the collections of the Joint Libraries of the Faculties of Philosophy and Sociology of the University of Warsaw, Institute of Philosophy and Sociology of the Polish Academy of Sciences, and the Polish Philosophical Society”[1]. Professor Adam Schaff (1913–2006) gathered an extensive book collection during his many years of academic work, falling during the Polish People’s Republic period. After his death, it was transferred to the Joint Libraries of WFiS UW, IFiS PAN, and PTF[2]. A. Schaff maintained contact with many foreign scholars specializing in philosophy and sociology, which directly influenced the analyzed collection. The article contains a qualitative, quantitative, and provenance analysis of this book collection. Provenance and bibliographic methods were used to study the characteristics of selected copies, making it possible to reconstruct Schaff’s contacts with the foreign scientific community.

[1] Master’s thesis, supervisor: Prof. Jacek Puchalski, University of Warsaw, 2023.

[2] Joint Libraries of the Faculties of Philosophy and Sociology of the University of Warsaw, the Institute of Philosophy and Sociology of the Polish Academy of Sciences, and the Polish Philosophical Society (PB WFiS UW, IFiS PAN, and PTF) is the proper name of the institution established in the 1950s, which consisted of 3 combined libraries, with joint staff and premises, but separate assets and thematically complementary book collections in philosophy and sociology.
Differential abundance of microRNAs in seminal plasma extracellular vesicles (EVs) in Sahiwal cattle bull related to male fertility
Authors: Chauhan Vitika , Kashyap Poonam , Chera Jatinder Singh , Pal Ankit , Patel Aditya , Karanwal Seema , Badrhan Shiva , Josan Fanny , Solanki Subhash , Bhakat Mukesh , Datta Tirtha Kumar , Kumar Rakesh 
Published: October 2024

Sahiwal cattle, known for their high milk yield, are propagated through artificial insemination (AI) using male germplasm, largely contingent on semen quality. Spermatozoa, produced in the testes, carry genetic information and molecular signals essential for successful fertilization. Seminal plasma, in addition to sperm, contains nano-sized lipid-bound extracellular vesicles (SP-EVs) that carry key biomolecules, including fertility-related miRNAs, which are essential for bull fertility. The current study focused on miRNA profiling of SP-EVs from high-fertile (HF) and low-fertile (LF) Sahiwal bulls. SP-EVs were isolated using size exclusion chromatography (SEC) and characterized by dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA). Western blotting detected the EV-specific protein markers TSG101 and CD63. The DLS analysis showed SP-EV sizes of 170–180 nm in HF and 130–140 nm in LF samples. The NTA revealed particle concentrations of 5.76 × 1010 to 5.86 × 1011 particles/mL in HF and 5.31 × 1010 to 2.70 × 1011 particles/mL in LF groups, with no significant differences in size and concentration between HF and LF. High-throughput miRNA sequencing identified 310 miRNAs in SP-EVs from both groups, with 61 upregulated and 119 downregulated in HF bull. Further analysis identified 41 miRNAs with significant fold changes and p-values, including bta-miR-1246, bta-miR-195, bta-miR-339b, and bta-miR-199b, which were analyzed for target gene prediction. Gene Ontology (GO) and KEGG pathway analyses indicated that these miRNAs target genes involved in transcription regulation, ubiquitin-dependent endoplasmic reticulum-associated degradation (ERAD) pathways, and signalling pathways. Functional exploration revealed that these genes play roles in spermatogenesis, motility, acrosome reactions, and inflammatory responses. qPCR analysis showed that bta-miR-195 had 80% higher expression in HF spermatozoa compared to LF, suggesting its association with fertility status (p &lt; 0.05). In conclusion, this study elucidates the miRNA cargoes in SP-EVs as indicators of Sahiwal bull fertility, highlighting bta-miR-195 as a potential fertility factor among the various miRNAs identified.