bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomewide landscape of gene–metabolome associations in Escherichia coli
Authors: Fuhrer Tobias , Zampieri Mattia , Sévin Daniel C , Sauer Uwe , Zamboni Nicola 
Published: January 2017

AbstractMetabolism is one of the best‐understood cellular processes whose network topology of enzymatic reactions is determined by an organism's genome. The influence of genes on metabolite levels, however, remains largely unknown, particularly for the many genes encoding non‐enzymatic proteins. Serendipitously, genomewide association studies explore the relationship between genetic variants and metabolite levels, but a comprehensive interaction network has remained elusive even for the simplest single‐celled organisms. Here, we systematically mapped the association between > 3,800 single‐gene deletions in the bacterium Escherichia coli and relative concentrations of > 7,000 intracellular metabolite ions. Beyond expected metabolic changes in the proximity to abolished enzyme activities, the association map reveals a largely unknown landscape of gene–metabolite interactions that are not represented in metabolic models. Therefore, the map provides a unique resource for assessing the genetic basis of metabolic changes and conversely hypothesizing metabolic consequences of genetic alterations. We illustrate this by predicting metabolism‐related functions of 72 so far not annotated genes and by identifying key genes mediating the cellular response to environmental perturbations.
Control del ácaro <i>Varroa destructor</i> en cría sellada de obrera al utilizar ácido fórmico y timol, en colmenas de abejas africanizadas, bajo condiciones tropicales. Nota Técnica
Authors: Ramírez Marianyela , Calderón Rafael A. 
Published: January 2017

Se evaluó la mortalidad del ácaro Varroa destructor en cría sellada de obrera, al aplicar ácido fórmico y timol en colmenas de abejas africanizadas. El apiario se ubicó en Atenas, Alajuela - Costa Rica. Este se dividió en tres grupos seleccionados al azar (A, B y C). El grupo A fue tratado con 150 g de ácido fórmico al 65%; en el B se realizó dos aplicaciones de 25 g de timol; el C se utilizó como testigo. La mortalidad de los diferentes estadios de varroa fue evaluada en cría sellada de obrera, revisando la pupa y el fondo de la celda. Se determinó una mortalidad de 86% en los diferentes estadios de varroa en cría sellada de obrera luego de aplicar ácido fórmico. Mientras que en colmenas tratadas con timol y el grupo testigo, la muerte de ácaros, en cría sellada, fue menor a un 10%. Se concluye que, al aplicar ácido fórmico, se produce una alta mortalidad de los diferentes estadios del ácaro V. destructor en la cría sellada de obrera. Mientras tanto, en las colmenas tratadas con timol y el grupo testigo, la mortalidad de ácaros fue considerablemente menor, lo cual puede indicar un efecto directo del ácido fórmico sobre los ácaros presentes en la cría sellada de obrera.
Tonsillectomy for Obstructive Sleep-Disordered Breathing: A Meta-analysis
Authors: Chinnadurai Sivakumar , Jordan Atia K. , Sathe Nila A. , Fonnesbeck Christopher , McPheeters Melissa L. , Francis David O. 
Published: January 2017

CONTEXT:
The effectiveness of tonsillectomy or adenotonsillectomy (hereafter, “tonsillectomy”) for obstructive sleep-disordered breathing (OSDB) compared with watchful waiting with supportive care is poorly understood.

OBJECTIVE:
To compare sleep, cognitive or behavioral, and health outcomes of tonsillectomy versus watchful waiting with supportive care in children with OSDB.

DATA SOURCES:
Medline, Embase, and the Cochrane Library.

STUDY SELECTION:
Two investigators independently screened studies against predetermined criteria.

DATA EXTRACTION:
Two investigators independently extracted key data. Investigators independently assessed study risk of bias and the strength of the evidence of the body of literature. Investigators synthesized data qualitatively and meta-analyzed apnea–hypopnea index (AHI) scores.

RESULTS:
We included 11 studies. Relative to watchful waiting, most studies reported better sleep-related outcomes in children who had a tonsillectomy. In 5 studies including children with polysomnography-confirmed OSDB, AHI scores improved more in children receiving tonsillectomy versus surgery. A meta-analysis of 3 studies showed a 4.8-point improvement in the AHI in children who underwent tonsillectomy compared with no surgery. Sleep-related quality of life and negative behaviors (eg, anxiety and emotional lability) also improved more among children who had a tonsillectomy. Changes in executive function were not significantly different. The length of follow-up in studies was generally &lt;12 months.

LIMITATIONS:
Few studies fully categorized populations in terms of severity of OSDB; outcome measures were heterogeneous; and the durability of outcomes beyond 12 months is not known.

CONCLUSIONS:
Tonsillectomy can produce short-term improvement in sleep outcomes compared with no surgery in children with OSDB. Understanding of longer-term outcomes or effects in subpopulations is lacking.
Estrategia sociocultural para la inserción del Adulto Mayor en las actividades de desarrollo social comunitario.
Authors: Conde Eddy , Cándano Baullosa Diana Rosa 
Published: January 2017

<p>Cuba presenta los índices de envejecimiento más elevados de América Latina, con un 16 % y una esperanza de vida que sobrepasa los 77 años. La presente investigación tiene como objetivo:</p><p>Socializar los resultados obtenidos a partir de la implementación de una estrategia sociocultural para la inserción del adulto mayor en las actividades de desarrollo social comunitario, que permitió elevar su protagonismo. Esta se clasifica como explicativa, se utilizaron métodos como el histórico-lógico, analítico-sintético, el sistémico-estructural, y la Investigación Acción Participativa. Entre las técnicas aplicadas, se encuentra la entrevista, el grupo de discusión, y el análisis documental. Se arribó a la tesis que: una mejor atención integral al adulto mayor requiere, además de la médica, de acciones sociales participativas.</p>
Estudio exploratorio sobre las inferencias generadas por el texto de poesía religiosa, en los jóvenes universitarios de la carrera de comunicación social de la universidad politécnica salesiana de Guayaquil.
Authors: Merchan arias Hugo Alain 
Published: January 2017

<p>El presente trabajo es una investigación exploratoria cualitativa sobre las inferencias que se generan a partir de la lectura de poesía religiosa, con la intensión de para rescatar y valorizar este género literario en la ciudad portuaria de Guayaquil. Planteándonos conocer que inferencia son producido luego de leer poesía religiosa guayaquileña, Se pudo determinar por medio del análisis de contenido, que los jóvenes coinciden con el valor trasmitidos por los poetas en comparación a la música de reggaetón, que no genera ningún tipo de inferencias en los participantes universitarios, las inferencias generadas por la poesía religiosa están relacionadas con la Vinculación de respeto ecológico; El sentido de amar en nuestras interrelaciones; Capacidad creativa para superar las adversidades de la vida con ayuda de los pares; como el equilibrio integrar del dolor y el amor para sobreponerse a las pruebas de la vida; y conexión cognitiva con lo divino.</p>
Antropología del cuerpo y el dolor
Authors: Muñoz Mainato Manuel Enrique 
Published: January 2017

<p>El culto al cuerpo está presente en todas las culturas y épocas histórica, así como “la experiencia del dolor” que ha conducido a los seres humanos al ejercicio del dominio y del poder de unos sobre otros mediante la aplicación de dolor sobre los cuerpos; verbigracia el dominio ideológico de tinte religioso ejercido por los patriarcas hebreos, los cultos sumerios, mesopotámicos, egipcios, griegos, romanos, aztecas, mayas, incas, etc. Durante el Medievo se constató esta realizad con más claridad. Un cuerpo torturado, sometido al dolor y al suplicio no es sino un referente pedagógico para sus congéneres. El miedo, el terror son patrones que diseñan un tipo de conducta humana, hacen de los seres humanos unos instrumentos de utilidad de los poderosos, de los delincuentes, de los narcotraficantes cuyo único propósito es acrecentar su imperio del capital por el poder de las armas.</p>
Frailty decreases physical health domain of quality of life in nursing home elderly
Authors: Handajani Yvonne Suzy , Widjaja Nelly Tina , Turana Yuda 
Published: January 2017

BACKGROUND <br />Approximately 10-27% of the population aged &gt;65 years suffers from frailty. The percentage increases with age so that the prevalence of frailty in the population aged &gt;85 years reaches 45%. The objective of this study was to determine the relationship between frailty and quality of life (QOL) in nursing home elderly. <br /><br />METHODS <br />This was a cross-sectional study of 138 subjects aged &gt;60 years who were recruited from 4 nursing homes in West Jakarta. Participants with frailty status were evaluated by the Survey of Health, Ageing and Retirement in Europe (SHARE) instrument and QOL was evaluated by the WHOQOL-BREF questionnaire. One-way ANOVA and chi-square tests were used to find relations between the frailty syndrome and QOL. <br /><br />RESULTS<br />The percentages of respondents with pre-frail, frail, and non-frail status were 30.4%, 52.2%, and 17.4%, respectively. A decline in QOL scores of pre-frail and frail respondents was found for almost all QOL domains (physical, psychological and environment domains), except social relationships. The subdomains most influenced were “energy and fatigue” in the physical health domain, “thinking, learning, memory and concentration” in psychological health, and “opportunities for acquiring new information and skills” in the environment domain.<br /><br />CONCLUSIONS <br />More than half of the nursing home elderly were frail and one-third were pre-frail. The main factor of frailty was weakness. The frailty syndrome in the elderly has a negative impact on QOL, especially in the physical health, psychological and environment domains in nursing home elderly.<br /><br />
Renal cortex echogenicity increases degree of retinopathy in diabetes mellitus
Authors: Maulidawati Indah , Lubis Abdurrahim Rasyid , Lindarto Dharma 
Published: January 2017

Background<br />The number of people with diabetes mellitus (DM) is increasing due to population growth, aging, and increasing prevalence of obesity. Diabetic retinopathy and diabetic nephropathy are two main complications of DM. Some studies suggest a correlation between diabetic nephropathy and diabetic retinopathy. However, other studies found that renal cortex echogenicity is associated with chronicity of kidney disease and renal histopathology. The aim of this study was to determine whether there is a correlation between renal cortex echogenicity as determined by renal ultrasonography and degree of retinopathy as determined by funduscopy in subjects with DM.<br /><br />Methods<br />A cross sectional study was conducted on 41 DM subjects from September to November 2014. Data obtained by anamnesis, physical examination, and examination of ureum, creatinine, urinalysis, glycated hemoglobin (HbA1c), renal and urinary tract ultrasonography and funduscopy, were collected from all subjects. Blood samples were taken from the median cubital vein for biochemical measurements using COBAS automated analyzers. Normality of data distribution was tested using the Shapiro-Wilk test. To determine the relationship between variables the Spearman correlation test was used. <br /><br />Results<br />Using the Spearman correlation test, a strongly significant correlation was found between degree of renal cortex echogenicity and degree of retinopathy (r=0.773; p=0.0001). A significant relationship was also found for the degree of retinopathy with age (r=0.317; p=0.044), duration of diabetes mellitus (r=0.639; p=0.0001) and HbA1c (r=0.681; p=0.001).<br /><br />Conclusion<br />This study found that renal cortex echogenicity increased the degree of diabetic retinopathy in diabetic subjects. Renal ultrasonography for patients with type 2 DM has a great role in diagnosing and grading diabetic retinopathy.
NCEP-ATP III and IDF criteria for metabolic syndrome predict type 2 diabetes mellitus
Authors: Sulistiowati Eva , Sihombing Marice 
Published: January 2017

<p><strong>Background</strong><strong></strong></p><p>Subjects with metabolic syndrome (MetS) have a greater risk for acquiring type 2 diabetes mellitus (type 2 DM). The MetS criteria usually used are those of the National Cholesterol Education Program Expert Panel (NCEP) and Adult Treatment Panel III (ATP III) and of the International Diabetes Federation (IDF). This study aimed to evaluate the modified NCEP-ATP III and IDF criteria as predictor of type 2 DM among subjects with MetS.</p><p> </p><p><strong>Methods</strong></p><p>A cohort study was conducted among 4240 subjects with MetS. MetS was determined according to the modified NCEP-ATP III and IDF criteria. The study followed up 3324 non-diabetic subjects of the cohort study of non-communicable disease (NCD) risk factors (NCD study) during a 2-year period. Type 2 DM was determined from the diagnosis by health personnel or from fasting blood glucose of ≥126 mg/dL or blood glucose of ≥200 mg/dL, 2 hours after 75g glucose loading.</p><p> </p><p><strong>Results</strong></p><p>The MetS prevalence based on modified NCEP ATP III and IDF criteria in non-DM subjects was 17.1% and 15.6%, respectively. The risk for DM in subjects with MetS using modified NCEP ATP III and IDF criteria was 4.7 (CI 95%: 3.4-6.5) and 4.1 (CI 95%: 3.0-5.7), respectively.</p><p> </p><p><strong>Conclusions</strong></p><p>Both MetS criteria can be used as predictors of the occurrence of DM type 2, but the modified NCEP-ATP III is more properly applied than the IDF criteria in subjects with MetS. Screening programs and routine monitoring of MetS components are required for early detection of type 2 DM.</p>
Análise das condições sinóticas de eventos de ondas de tempestade no litoral norte fluminense
Authors: Amorim Isadora Borges da Silva , Bulhões Eduardo 
Published: January 2017

O presente estudo justifica-se pela necessidade de incorporar análises das condições de circulação atmosférica, na escala sinótica, aos estudos de impactos de ondas de tempestade na linha de costa, utilizando para tal o suporte do conhecimento já gerado para a Bacia de Campos. Nesse sentido, o objetivo do presente trabalho é identificar e caracterizar as condições sinóticas atmosféricas quando da ocorrência de ondas oceânicas de tempestade no Atlântico Sudoeste, especialmente aquelas que atingem o litoral fluminense, buscando identificar padrões atmosféricos de geração, propagação e dispersão de eventos de ondas de tempestade, entre os anos de 2004 e 2014. A estratégia metodológica foi inicialmente definir os eventos de tempestade no período, os quais geraram impactos significativos no litoral fluminense, descrevendo as condições sobre as quais ocorreram. Para essa tarefa são utilizados dados compilados do modelo Wave Watch III. Em seguida, foram descritas as etapas de identificação de impactos na linha de costa, a partir dos resultados de simulações de propagação de ondas para o litoral. Posteriormente, foram selecionadas as informações de cartas sinóticas publicadas diariamente pela Marinha do Brasil durante os eventos de aproximação, atuação e dispersão das tempestades oceânicas que atingiram o litoral fluminense. Por fim, foram descritas e mapeadas as condições sinóticas geradoras de ondas de tempestade para o litoral supracitado. Como resultados, identificou-se que os padrões de trajetórias distintas dos centros de baixa pressão variam entre os sentidos sudoeste para nordeste, su-sudoeste para leste-nordeste e noroeste para sudeste; sendo este último referente a um posicionamento dos ciclones mais próximo ao litoral fluminense. Foi inferido também que a posição e a intensidade do vórtice de alta pressão do Atlântico Sul (ASAS) interferem nas trajetórias dos centros de baixa pressão. No momento de dissipação, as trajetórias são de oeste para leste. O evento de novembro de 2008 é diagnóstico de ondas intensas relacionadas à posição do centro de alta pressão do Atlântico Sul (ASAS).
DAYA SAING DAN FAKTOR PENENTU EKSPOR KOPI INDONESIA KE MALAYSIA DALAM SKEMA CEPT-AFTA
Authors: Setiawan Achmad Edi , Sugiarti Teti 
Published: January 2017

<p>CEPT-AFTA dapat menjadi peluang untuk meningkatkan ekspor kopi Indonesia ke Malaysia, namun dalam perkembangannya ekspor kopi Indonesia ke Malaysia fluktuatif. Penelitian ini bertujuan menganalisis daya saing dan faktor penentu ekspor kopi Indonesia ke Malaysia dalam skema CEPT-AFTA. Metode yang digunakan yaitu Revealed Comparative Advantage (RCA) untuk menganalisis daya saing ekspor kopi Indonesia di pasar Malaysia dan metode regresi linier berganda untuk menganalisis faktor-faktor yang mempengaruhi ekspor kopi Indonesia ke Malaysia. Hasil dari analisis RCA menunjukkan bahwa kopi Indonesia di Pasar Malaysia memiliki daya saing (nilai RCA&gt;1) namun mengalami penurunan daya saing setelah diberlakukannya CEPT-AFTA. Hasil estimasi analisis regresi linier berganda menunjukkan bahwa faktor-faktor yang mempengaruhi ekspor kopi Indonesia ke pasar Malaysia adalah produksi kopi Indonesia, harga ekspor kopi Indonesia ke Malaysia, dan nilai tukar rupiah terhadap dollar Amerika. Sedangkan nilai RCA dan dummy CEPT-AFTA tidak berpengaruh</p>
Comments: Ending the US Export Ban
Authors: Donnelly John 
Published: January 2017

Editor's column
US companies began selling crude oil on the international market last month shortly after the US Congress ended the country’s 40-year-old ban on oil exports. The action is another byproduct of the US shale revolution and will do little to settle the current fight over global oil market share that has driven oil prices to decade lows.
Congress enacted the ban in 1975, after the OPEC oil embargoes against the US in the 1970s drove gasoline retail prices higher and caused regional gasoline shortages. There has been an occasional relaxing of the ban, such as in the 1980s when shipments of crude began being allowed to Canada and in the 1990s when sales of Alaskan North Slope crude were permitted to relieve a glut of heavy oil on the US west coast. Last year, the ban on shipments of condensate was lifted, and both Pioneer Natural Resources and Enterprise Product Partners began selling condensate overseas.
The first sales of US crude took place on 31 December and in the first week of January as ConocoPhillips and Enterprise shipped cargoes from Texas to Europe. The recent drilling boom in south and west Texas has ushered in a buildup in infrastructure to the refineries along the US Gulf Coast, which will make export easier.
The shale boom made the argument in favor of the embargo seem antiquated. After falling steadily since 1985, US crude production began increasing in 2009 with the sharp rise in shale output. In 2009, US output rose to 5.4 million B/D and increased to 9.3 million B/D last year, as the country almost doubled production, according to the US Energy Information Administration. The US now rivals Saudi Arabia and Russia in terms of energy output and its crude production now surpasses its oil imports.
In the short term, US crude exports should have little effect on the global oil market or oil prices. The world is currently awash in supply and shipping US crude to far-away places such as Asia is uneconomic compared with cheaper oil offered from the Middle East. But in the long term, when the global supply/demand balance tightens, Asia will have another option for crude, especially after a planned expansion of the Panama Canal is completed. Latin America may be a natural outlet for US oil as its refineries are geared to running the light, sweet crude such as that which comes from the Eagle Ford Shale. Most of the refineries on the US Gulf Coast are built to process heavier crude. Shale producers will have another market for their crude, which should encourage production once oil price levels rise again. A study by Columbia University predicted that lifting the export ban could increase US crude oil production by 1.2 million B/D.
The American Petroleum Institute, which lobbied to lift the ban, said the US will now be a major player in the global oil market. While that is not likely in the short_ term, lifting the ban does add another wrinkle to the current battle over global oil market share, which has changed OPEC strategy and caused crude prices to plummet. JPT
Lingering Global Oil Bust Will Lead to Lasting Changes
Authors: Rassenfoss Stephen 
Published: January 2017

Predictions of a 2016 recovery in the exploration and production (E&P) sector became increasingly rare after 2015 ended with a thud as oil prices sank below USD 40/bbl.
The industry consensus now is that oil and gas prices are going lower for longer, and activity in 2016 will be lower than in 2015, said Ethan Phillips, a leader in the oil and gas practice at Bain & Co. “We are coming around to the notion that when the industry does come back it will look different.”
Oil prices now are no more predictable than they were in December when they unexpectedly slid from around USD 50/bbl to around USD 35/bbl. For many companies that spent last year struggling to eke out a profit at USD 50/bbl in high-cost plays, from deepwater development to shale, that pushed the break-even point beyond reach.
In the coming years, production growth is expected largely from low-cost producers in the Middle East, led by Saudi Arabia, which has stuck with its plan to regain market share, even if that means keeping oil prices low. A spike in tensions between Iran and Saudi Arabia and its allies in early January was a reminder of the political risk associated with the region. But bad market news from China snuffed an oil market rally by showing its appetite for hydrocarbons this year likely will be limited.
While US producers proved surprisingly resilient in 2015—with new platforms in the Gulf of Mexico pushing up the total US annual output—that does not appear sustainable. Lower prices have led to steep reductions in reserve estimates in high-cost plays, increasing pressure from investors and lenders to deal with the problems created by dwindling cash flows. And the cost per barrel in deep water plays is delaying many projects there.
Investment bankers and private equity investors once eager to put money into unconventional E&P have turned their attention to profiting from distressed E&P deals.
“A few of the things that were kind of propping revenues and activity levels are playing out,” said Karr Ingham, consulting economist for the Texas Alliance of Energy Producers, adding, “It is increasingly apparent that activity levels will drop by more than they are now.”