bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessment of Groundwater Potential of Gandhinagar Region, Gujarat
Authors: Siddha Swayam , Sahu Paulami 
Published: January 2018

ABSTRACT
With burgeoning population, the groundwater demands of any area increased by many fold and therefore, it is essential to assess the groundwater potential to choose suitable sites for further groundwater development. Present study determines the groundwater potential of different parts of Gandhinagar region located at Gandhinagar district, Gujarat, India. Here, excluding city dwellers, all villagers are mostly dependent on groundwater for drinking and domestic purposes. With increasing population, there is a rise in daily human consumption and hence reduction in groundwater quantity. Various types of industries of Gandhinagar such as textile industries, food processing industries, ceramic industries etc. also require groundwater. Industrial discharges deteriorate the water quality of this region. Therefore, water level monitoring and quality assessment of groundwater in regular intervals is essential. The groundwater potential zoning is an indicator, which gives the overall idea about the groundwater condition. Overlay analysis in GIS using multiple criteria such as WQI, hydraulic conductivity, groundwater velocity, and depth to piezometric surface discloses that there are five groundwater potential zones in Gandhinagar region. This study reveals that majority of the study area is covered with medium potential zone. Different management plans such as treated surface water supply, reduction in tubewell operation time, development of rooftop rainwater harvesting system and artificial recharge system etc. are recommended for different potential zones for sustainable development of groundwater of Gandhinagar region.
CDK5RAP2 gene and tau pathophysiology in late‐onset sporadic Alzheimer's disease
Authors: Miron Justin , Picard Cynthia , Nilsson Nathalie , Frappier Josée , Dea Doris , Théroux Louise ,   Alzheimer's Disease Neuroimaging Initiative,   United Kingdom Brain Expression Consortium, Poirier Judes 
Published: January 2018

AbstractIntroductionBecause currently known Alzheimer's disease (AD) single‐nucleotide polymorphisms only account for a small fraction of the genetic variance in this disease, there is a need to identify new variants associated with AD.MethodsOur team performed a genome‐wide association study in the Quebec Founder Population isolate to identify novel protective or risk genetic factors for late‐onset sporadic AD and examined the impact of these variants on gene expression and AD pathology.ResultsThe rs10984186 variant is associated with an increased risk of developing AD and with a higher CDK5RAP2 mRNA prevalence in the hippocampus. On the other hand, the rs4837766 variant, which is among the best cis‐expression quantitative trait loci in the CDK5RAP2 gene, is associated with lower mild cognitive impairment/AD risk and conversion rate.DiscussionThe rs10984186 risk and rs4837766 protective polymorphic variants of the CDK5RAP2 gene might act as potent genetic modifiers for AD risk and/or conversion by modulating the expression of this gene.
Rationale and concept for a lunar pit reconnaissance probe
Authors: Dorrington G. E. 
Published: January 2018

ABSTRACTSpeculation on near-term scientific reasons for the exploration of lunar pits is offered alongside comments on possible longer-term human exploitation. It is proposed that in order to determine whether or not one or more of the pits offer access the large subsurface voids e.g. a non-collapsed lava tube, a preliminary reconnaissance mission solely focused on obtaining lateral images (and/or LiDAR maps) is needed. Possible concept options for such a preliminary reconnaissance mission are discussed. It is suggested that one of the best possible strategies is to employ a micro-sized probe (~0.3 m) that would hop from a nearby main landing spacecraft to the selected pit. After the surface position of the main lander is determined accurately, the probe would perform a ballistic hop, or hover-traverse, a distance of ~3 km over the lunar surface using existing propulsive and guidance technology capability. Once hovering above the pit, the probe or a separate tethered imaging unit would then be lowered into the pit to acquire the necessary subsurface void topology data. This data would then be transmitted back to Earth, directly, via the lander, or via a store-and-forward orbiting relay. Preliminary estimates indicate that a probe of ~14 kg (dry mass) is viable using a conventional hydrazine monopropellant system with a propellant mass fraction of less than ~0.2 (20%) including margins, suggesting a piggyback architecture would be feasible.
PARSIMONIOUS PARAMETERIZATION OF AGE-PERIOD-COHORT MODELS BY BAYESIAN SHRINKAGE - ERRATUM
Authors: Venter Gary , Şahın Şule 
Published: January 2018

In Venter and Şahin (2017), the author's name appeared incorrectly as “ŞULE ŞAHÎN”.The author's name should appear as “ŞULE ŞAHİN”.The original article has been corrected to rectify this error.
To Do No Harm: Humanitarian Aid in Conflict Demands Political Engagement
Authors: Patel Ronak B. , Wild Hannah B. 
Published: January 2018

AbstractHumanitarian aid in settings of conflict has always been fraught with challenges. In the absence of political engagement, however, manipulation by state authorities, however, have the potential to pervert aid intervention to inflict harm. South Sudan exemplifies how states may abuse the humanitarian response to retreat from public responsibility, divert funds to further violence and conflict and dictate the distribution of aid. Recent trends toward nationalist policies in the West that favor disengagement and limited military strikes have the very effect of allowing this abuse to transform humanitarian aid into a tool for harm. (Disaster Med Public Health Preparedness. 2018;12:567–568)
External Appeal, Internal Dominance: How Party Leaders Contribute to Successful Party Building
Authors: Van Dyck Brandon 
Published: January 2018

AbstractMany successful political parties depend for their initial popularity and cohesion, and even for their long-term brand strength, on a leader. Nevertheless, literature on successful party building downplays the role of leaders. Thus, the question, what type of leader is good for party building?, remains undertheorized. This article presents and provides initial evidence for a leadership-centered theory of successful party building. It argues that externally appealing, internally dominant leaders facilitate party building by lifting new parties to electoral prominence and helping to prevent debilitating schisms. The article provides evidence for this argument through a most similar cases comparison of three new left parties in Latin America: two that took root (Brazil’s Workers’ Party, Mexico’s Party of the Democratic Revolution), and one that collapsed (Peru’s United Left).
Setting the Regional Agenda: A Critique of Posthegemonic Regionalism
Authors: Petersen Mark , Schulz Carsten-Andreas 
Published: January 2018

AbstractThere is a growing scholarly consensus that Latin American regionalism has entered a new phase. For some observers, the increasing complexity of regional cooperation initiatives renders collective action ineffective. For others, the creation of new schemes signals a “posthegemonic” moment that has opened a space for collaboration on social issues. Both camps attribute this shift to the absence of the United States and the presence of left-leaning governments. By contrast, this study demonstrates that this agenda is not new, nor has the United States impeded similar initiatives in the past. In fact, the United States was instrumental in expanding regional cooperation on social issues in the early twentieth century. Instead, this article argues that agenda shifts are best explained by an evolving consensus about the role of the state. The “new agenda” is in line with historical attempts by governments to use regionalism to bolster their own domestic reforms.
Electoral Reform Under Limited Party Competition: The Adoption of Proportional Representation in Latin America
Authors: Negretto Gabriel L. , Visconti Giancarlo 
Published: January 2018

AbstractThe adoption of proportional representation in Western Europe has been portrayed as either a defensive or an offensive competition strategy used by established parties to deal with the rise of new parties under majoritarian electoral rules. Neither explanation accounts for PR reform in other regions of the world, where the change took place in the absence of increased party competition. Analyzing the history of electoral reform in Latin America, this article argues that in a context of limited party competition, the initial adoption of PR was part of a strategy of controlled political liberalization promoted by authoritarian rulers. Subdividing this general reasoning, the article shows that PR reform followed different paths depending on the nature of the authoritarian regime and the events that called into question the existing majoritarian electoral system. This argument is supported with a comparative historical analysis of cases within and across each route to reform.
The Racialized Effects of Social Programs in Brazil
Authors: De Micheli David 
Published: January 2018

AbstractStudies of the electoral effects of cash transfer programs in Latin America have largely treated the poor as a unitary group. This study considers how the effects of social benefits vary across groups among the targeted poor by exploring the consequences of race for the electoral effects of Brazil’s Bolsa Família program. A matching analysis of LAPOP survey data shows that race shapes baseline propensities to participate in elections and to support the incumbent PT at the polls; these tendencies then shape the mechanisms through which cash transfers boost support for the incumbent. Benefits mobilize Afro-Brazilians to participate but have little effect on their vote choice. By contrast, benefits have little effect on whites’ participation but persuade them to support the PT over the opposition. This article deepens understanding of how social benefits affect the electoral behavior of recipients and highlights how race shapes political behavior among the poor.
Costs and Benefits of Overlapping Regional Organizations in Latin America: The Case of the OAS and UNASUR
Authors: Nolte Detlef 
Published: January 2018

AbstractThis article investigates whether the overlapping of intergovernmental regional organizations in Latin America with regard to membership and mandate is harmful or beneficial to regional cooperation (with a special focus on mediation in domestic and international conflicts). The article begins by systematizing the discussion about the possible risks and potential benefits of overlapping regional organizations, and then outlines hypotheses that can be tested in concrete episodes of overlap of action. The article then analyzes nine episodes in which an overlap of action has occurred between two Latin American organizations, the Organization of American States (OAS) and the Union of South American Nations (UNASUR). The results of the study are mixed. However, the effects of overlapping seem to be much less problematic than a large body of literature generally assumes.
The Effects of Betaine on the Nuclear Fractal Dimension, Chromatin Texture, and Proliferative Activity in Hepatocytes in Mouse Model of Nonalcoholic Fatty Liver Disease
Authors: Vesković Milena , Labudović-Borović Milica , Zaletel Ivan , Rakočević Jelena , Mladenović Dušan , Jorgačević Bojan , Vučević Danijela , Radosavljević Tatjana 
Published: January 2018

AbstractThe effects of betaine on hepatocytes chromatin architecture changes were examined by using fractal and gray-level co-occurrence matrix (GLCM) analysis in methionine/choline-deficient (MCD) diet-induced, nonalcoholic fatty liver disease (NAFLD). Male C57BL/6 mice were divided into groups: (1) Control: standard diet; (2) BET: standard diet and betaine supplementation through drinking water (solution 1.5%); (3) MCD group: MCD diet for 6 weeks; (4) MCD+BET: fed with MCD diet + betaine for 6 weeks. Liver tissue was collected for histopathology, immunohistochemistry, and determination of fractal dimension and GLCM parameters. MCD diet induced diffuse micro- and macrovesicular steatosis accompanied with increased Ki67-positive hepatocyte nuclei. Steatosis and Ki67 immunopositivity were less prominent in the MCD+BET group compared with the MCD group. Angular second moment (ASM) and inverse difference moment (IDM) (textural homogeneity markers) were significantly increased in the MCD+BET group versus the MCD group (p<0.001), even though no difference between the MCD and the control group was evident. Heterogeneity parameters, contrast, and correlation were significantly increased in the MCD group versus the control (p<0.001). On the other hand, betaine treatment significantly reduced correlation, contrast, and entropy compared with the MCD group (p<0.001). Betaine attenuated MCD diet-induced NAFLD by reducing fat accumulation and inhibiting hepatocyte proliferation. Betaine supplementation increased nuclear homogeneity and chromatin complexity with reduction of entropy, contrast, and correlation.
Evaluation of Chemical Termination Options for Cover Crops
Authors: Palhano Matheus G. , Norsworthy Jason K. , Barber Tom 
Published: January 2018

AbstractCover crop acreage has substantially increased over the last few years due to the intent of growers to capitalize on federal conservation payments and incorporate sustainable practices into agricultural systems. Despite all the known benefits, widespread adoption of cover crops still remains limited due to potential cost and management requirements. Cover crop termination is crucial, because a poorly controlled cover crop can become a weed and lessen the yield potential of the current cash crop. A field study was conducted in fall 2015 and 2016 at the Arkansas Agricultural Research and Extension Center in Fayetteville to evaluate preplant herbicide options for terminating cover crops. Glyphosate-containing treatments controlled 97% to 100% of cereal rye and wheat, but glyphosate alone controlled less than 57% of legume cover crops. The most effective way to control hairy vetch, Austrian winterpea, and crimson clover with glyphosate resulted from mixtures of glyphosate with glufosinate, 2,4-D, and dicamba. Higher rates of auxin herbicides improved control in these mixtures. Glufosinate alone or in mixture controlled legume cover crops 81% or more. Paraquat plus metribuzin was effective in terminating both cereal and legume cover crops, with control of cereal cover crops ranging from 87% to 97% and control of legumes ranging from 90% to 96%. None of these herbicides or mixtures adequately controlled rapeseed.
Targeting IL-2: an unexpected effect in treating immunological diseases
Authors: Ye Congxiu , Brand David , Zheng Song G. 
Published: January 2018

AbstractRegulatory T cells (Treg) play a crucial role in maintaining immune homeostasis since Treg dysfunction in both animals and humans is associated with multi-organ autoimmune and inflammatory disease. While IL-2 is generally considered to promote T-cell proliferation and enhance effector T-cell function, recent studies have demonstrated that treatments that utilize low-dose IL-2 unexpectedly induce immune tolerance and promote Treg development resulting in the suppression of unwanted immune responses and eventually leading to treatment of some autoimmune disorders. In the present review, we discuss the biology of IL-2 and its signaling to help define the key role played by IL-2 in the development and function of Treg cells. We also summarize proof-of-concept clinical trials which have shown that low-dose IL-2 can control autoimmune diseases safely and effectively by specifically expanding and activating Treg. However, future studies will be needed to validate a better and safer dosing strategy for low-dose IL-2 treatments utilizing well-controlled clinical trials. More studies will also be needed to validate the appropriate dose of IL-2/anti-cytokine or IL-2/anti-IL-2 complex in the experimental animal models before moving to the clinic.
FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway
Authors: Zhao Xiujuan , Wang Xing , Li Qian , Chen Wanbiao , Zhang Na , Kong Yu , Lv Junqiang , Cao Lei , Lin Dan , Wang Xi , Xu Guogang , Wu Xudong 
Published: January 2018

AbstractEpigenetic modifiers have emerged as critical factors governing the biology of different cancers. Herein we show that FBXL10 (also called KDM2B or JHDM1B), an important member of Polycomb repressive complexes, is overexpressed in human diffuse large B-cell lymphoma (DLBCL) tissues and the derived cell lines. Knocking down FBXL10 by specific short hairpin RNAs in DLBCL cells inhibits cell proliferation and induces apoptosis in vitro. Moreover, FBXL10 depletion in DLBCL cells abrogates tumor growth in mouse xenograft models. Through the analysis of RNA sequencing, we find that one of the key derepressed genes by depletion of FBXL10 is DUSP6, encoding a phosphatase for ERK1/2. Mechanistically FBXL10 maintains the silencing of DUSP6 expression via recruitment of Polycomb group proteins and deposition of repressive histone modifications at the DUSP6 promoter. Consistently, FBXL10 is required for ERK1/2 phosphorylation in DLBCL cells. Furthermore, we show that ERK1/2 activation and the proliferation rate of FBXL10-depleted cells can be rescued by downregulation of DUSP6 expression. These findings indicate that FBXL10 may be a promising therapeutic target in DLBCL and establish a link of epigenetic regulators to kinase signaling pathways.
Nucleolin and ErbB2 inhibition reduces tumorigenicity of ErbB2-positive breast cancer
Authors: Wolfson Eya , Solomon Shira , Schmukler Eran , Goldshmit Yona , Pinkas-Kramarski Ronit 
Published: January 2018

AbstractErbB2, a member of the ErbB family of receptor tyrosine kinases, is an essential player in the cell’s growth and proliferation signaling pathways. Amplification or overexpression of ErbB2 is observed in ∼30% of breast cancer patients, and often drives cellular transformation and cancer development. Recently, we have shown that ErbB2 interacts with the nuclear-cytoplasmic shuttling protein nucleolin, an interaction which enhances cell transformation in vitro, and increases mortality risk and disease progression rate in human breast cancer patients. Given these results, and since acquired resistance to anti-ErbB2-targeted therapy is a major obstacle in treatment of breast cancer, we have examined the therapeutic potential of targeting the ErbB2–nucleolin complex. The effect of the nucleolin-specific inhibitor GroA (AS1411) on ErbB2-positive breast cancer was tested in vivo, in a mouse xenograft model for breast cancer; as well as in vitro, alone and in combination with the ErbB2 kinase-inhibitor tyrphostin AG-825. Here, we show that in vivo treatment of ErbB2-positive breast tumor xenografts with GroA reduces tumor size and leads to decreased ErbB2-mediated signaling. Moreover, we found that co-treatment of breast cancer cell lines with GroA and the ErbB2 kinase-inhibitor tyrphostin AG-825 enhances the anti-cancer effects exerted by GroA alone in terms of cell viability, mortality, migration, and invasiveness. We, therefore, suggest a novel therapeutic approach, consisting of combined inhibition of ErbB2 and nucleolin, which has the potential to improve breast cancer treatment efficacy.
Melatonin inhibits apoptotic cell death induced by Vibrio vulnificus VvhA via melatonin receptor 2 coupling with NCF-1
Authors: Lee Sei-Jung , Lee Hyun Jik , Jung Young Hyun , Kim Jun Sung , Choi Sang Ho , Han Ho Jae 
Published: January 2018

AbstractMelatonin, an endogenous hormone molecule, has a variety of biological functions, but a functional role of melatonin in the infection of Gram-negative bacterium Vibrio vulnificus has yet to be described. In this study, we investigated the molecular mechanism of melatonin in the apoptosis of human intestinal epithelial (HCT116) cells induced by the hemolysin (VvhA) produced by V. vulnificus. Melatonin (1 μM) significantly inhibited apoptosis induced by the recombinant protein (r) VvhA, which had been inhibited by the knockdown of MT2. The rVvhA recruited caveolin-1, NCF-1, and Rac1 into lipid rafts to facilitate the production of ROS responsible for the phosphorylation of PKC and JNK. Interestingly, melatonin recruited NCF-1 into non-lipid rafts to prevent ROS production via MT2 coupling with Gαq. Melatonin inhibited the JNK-mediated phosphorylation of c-Jun responsible for Bax expression, the release of mitochondrial cytochrome c, and caspase-3/-9 activation during its promotion of rVvhA-induced apoptotic cell death. In addition, melatonin inhibited JNK-mediated phosphorylation of Bcl-2 responsible for the release of Beclin-1 and Atg5 expression during its promotion of rVvhA-induced autophagic cell death. These results demonstrate that melatonin signaling via MT2 triggers recruitment of NCF-1 into non-lipid rafts to block ROS production and JNK-mediated apoptotic and autophagic cell deaths induced by rVvhA in intestinal epithelial cells.
ZEB1 confers chemotherapeutic resistance to breast cancer by activating ATM
Authors: Zhang Xiang , Zhang Zhen , Zhang Qing , Zhang Quansheng , Sun Peiqing , Xiang Rong , Ren Guosheng , Yang Shuang 
Published: January 2018

AbstractAlthough zinc finger E-box binding homeobox 1 (ZEB1) has been identified as a key factor in the regulation of breast cancer differentiation and metastasis, its potential role in modulating tumor chemoresistance has not been fully understood. Here, through the study of specimens from a large cohort of human breast cancer subjects, we showed that patients with tumors that expressed high levels of ZEB1 responded poorly to chemotherapy. Moreover, ZEB1 expression was positively correlated with expression of B-cell lymphoma-extra large (Bcl-xL) and cyclin D1, which are key components of tumor chemoresistant mechanisms. At the molecular level, ectopic expression of ZEB1 impaired the responsiveness of breast cancer cells to genotoxic drug treatment, such as epirubicin (EPI). During this process, ZEB1 transcriptionally activated the expression of ataxia-telangiectasia mutated (ATM) kinase by forming a ZEB1/p300/PCAF complex on its promoter, leading to increased homologous recombination (HR)-mediated DNA damage repair and the clearance of DNA breaks. Using a nude mouse xenograft model, we further confirmed that ectopic expression of ZEB1 decreased breast cancer responsiveness to EPI treatment in vivo. Collectively, our findings suggest that ZEB1 is a crucial determinant of chemotherapeutic resistance in breast cancer.