bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovative approach for electrical characterisation of pseudo‐resistors
Authors: Benko P.L. , Galeti M. , Pereira C.F. , Lucchi J.C. , Giacomini R. 
Published: November 2016

Since the use of pseudo‐resistors became popular in of bio‐amplifiers research, several works have been published, but a lack of knowledge about accurate experimental characterisation and simulation of these non‐linear devices remains. An innovative experimental procedure concerning the characterisation of pseudo‐resistors is presented. The proposed experimental procedure proves the existence of a linear operation region, where the device can operate like a very high resistance, which is mainly applied on bio‐amplifier designs. The main experimental results of the electrical characterisation of pseudo‐resistors are described in detail and compared with the SPICE results. The pseudo‐resistor experimental curve response including the non‐linear operation region is presented. Finally, a new non‐linear polynomial resistor model to use in SPICE simulator, replacing with success the electrical representation model based on transistors models is proposed. The presented simulations were performed with Mentor Graphics EldoTM SPICE simulator, using BSIM3V3.1 and PSP103.1 models. The MOSIS Educational Program fabricated the samples used in this work.
Fabrication, characterisation and dielectric properties of KH550 modified BST/PVDF nanocomposites with high dielectric strength
Authors: Wang Li , Gao Feng , Xu Jie , Zhang Kena , Wang Min , Qin Mengjie 
Published: November 2016

Ba0.6Sr0.4TiO3 (BST)/poly(vinylidene fluoride) (PVDF) 0–3 nanocomposites with BST nanoparticle contents of 10–40 vol% were prepared by tape casting method. The BST nanoparticles with ∼60 nm crystal size and accurate atomic ratio were synthesised by sol–gel method. The effect of the BST nanoparticle contents on the microstructure and dielectric properties of BST/PVDF nanocomposites were investigated. The BST/PVDF nanocomposites system declares that feasibility of applying low contents nanoparticles to form a homogeneous distribution in polymer matrix, higher dense interface connectivity, thereby providing a significant improvement to the dielectric strength and energy storage density; meanwhile, the nanocomposites possess high dielectric tunability. In this study, the maximum dielectric strength ∼287.12 kV/mm and energy storage density ∼5.15 J/cm3 were obtained in 10 vol% BST/PVDF nanocomposites, respectively. Moreover, the nanocomposite possesses high dielectric tunability ∼62.6% at 58 kV/mm, which proposed the nanocomposites suitable for tunable microwave devices, supercapacitors and energy storage device applications at high‐voltage environment.
Simulations of recoiling black holes: adaptive mesh refinement and radiative transfer
Authors: Meliani Zakaria , Mizuno Yosuke , Olivares Hector , Porth Oliver , Rezzolla Luciano , Younsi Ziri 
Published: November 2016

Context. In many astrophysical phenomena, and especially in those that involve the high-energy regimes that always accompany the astronomical phenomenology of black holes and neutron stars, physical conditions that are achieved are extreme in terms of speeds, temperatures, and gravitational fields. In such relativistic regimes, numerical calculations are the only tool to accurately model the dynamics of the flows and the transport of radiation in the accreting matter.
Aims. We here continue our effort of modelling the behaviour of matter when it orbits or is accreted onto a generic black hole by developing a new numerical code that employs advanced techniques geared towards solving the equations of general-relativistic hydrodynamics.
Methods. More specifically, the new code employs a number of high-resolution shock-capturing Riemann solvers and reconstruction algorithms, exploiting the enhanced accuracy and the reduced computational cost of adaptive mesh-refinement (AMR) techniques. In addition, the code makes use of sophisticated ray-tracing libraries that, coupled with general-relativistic radiation-transfer calculations, allow us to accurately compute the electromagnetic emissions from such accretion flows.
Results. We validate the new code by presenting an extensive series of stationary accretion flows either in spherical or axial symmetry that are performed either in two or three spatial dimensions. In addition, we consider the highly nonlinear scenario of a recoiling black hole produced in the merger of a supermassive black-hole binary interacting with the surrounding circumbinary disc. In this way, we can present for the first time ray-traced images of the shocked fluid and the light curve resulting from consistent general-relativistic radiation-transport calculations from this process.
Conclusions. The work presented here lays the ground for the development of a generic computational infrastructure employing AMR techniques to accurately and self-consistently calculate general-relativistic accretion flows onto compact objects. In addition to the accurate handling of the matter, we provide a self-consistent electromagnetic emission from these scenarios by solving the associated radiative-transfer problem. While magnetic fields are currently excluded from our analysis, the tools presented here can have a number of applications to study accretion flows onto black holes or neutron stars.
Membrane protein structure determination by SAD, SIR, or SIRAS phasing in serial femtosecond crystallography using an iododetergent
Authors: Nakane Takanori , Hanashima Shinya , Suzuki Mamoru , Saiki Haruka , Hayashi Taichi , Kakinouchi Keisuke , Sugiyama Shigeru , Kawatake Satoshi , Matsuoka Shigeru , Matsumori Nobuaki , Nango Eriko , Kobayashi Jun , Shimamura Tatsuro , Kimura Kanako , Mori Chihiro , Kunishima Naoki , Sugahara Michihiro , Takakyu Yoko , Inoue Shigeyuki , Masuda Tetsuya , Hosaka Toshiaki , Tono Kensuke , Joti Yasumasa , Kameshima Takashi , Hatsui Takaki , Yabashi Makina , Inoue Tsuyoshi , Nureki Osamu , Iwata So , Murata Michio , Mizohata Eiichi 
Published: November 2016

Significance
This study shows successful experimental phasing methods (single-wavelength anomalous diffraction, single isomorphous replacement, and single isomorphous replacement with anomalous scattering) for crystal structure determination of a membrane protein by serial femtosecond crystallography with X-ray free electron lasers. Our iodine-containing detergent provided strong anomalous and isomorphous difference signals, which enabled experimental phasing using lower-resolution reflections (worse than 3 Å) from fewer indexed images than phasing attempts reported previously. The findings of this study will be applicable to a wide range of target proteins in structural biology, especially membrane proteins that often diffract to low resolution.
Piperine’s mitigation of obesity and diabetes can be explained by its up-regulation of the metabolic rate of resting muscle
Authors: Nogara Leonardo , Naber Nariman , Pate Edward , Canton Marcella , Reggiani Carlo , Cooke Roger 
Published: November 2016

Significance
We have developed a method for finding pharmaceuticals that would treat obesity and type 2 diabetes by increasing the metabolic rate of resting skeletal muscle. The metabolic rate is increased by shifting the motor protein myosin from a low activity state to a higher activity state. We devised an assay, screened for compounds, and found one molecule, piperine. Piperine increased the metabolic rate of resting muscle fibers. Piperine does not have the properties required to be a pharmaceutical in humans, but it would make a good lead compound for finding compounds that do. Our results provide proof of concept that these metabolic diseases can be treated by future pharmaceuticals that target myosin to increase the metabolism of excess calories.
Global environmental drivers of influenza
Authors: Deyle Ethan R. , Maher M. Cyrus , Hernandez Ryan D. , Basu Sanjay , Sugihara George 
Published: November 2016

Significance
Patterns of influenza outbreak are different in the tropics than in temperate regions. Although considerable experimental progress has been made in identifying climate-related drivers of influenza, the apparent latitudinal differences in outbreak patterns raise basic questions as to how potential environmental variables combine and act across the globe. Adopting an empirical dynamic modeling framework, we clarify that absolute humidity drives influenza outbreaks across latitudes, find that the effect of absolute humidity on influenza is U-shaped, and show that this U-shaped pattern is mediated by temperature. These findings offer a unifying synthesis that explains why experiments and analyses disagree on this relationship.
Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma
Authors: Hideshima Teru , Qi Jun , Paranal Ronald M. , Tang Weiping , Greenberg Edward , West Nathan , Colling Meaghan E. , Estiu Guillermina , Mazitschek Ralph , Perry Jennifer A. , Ohguchi Hiroto , Cottini Francesca , Mimura Naoya , Görgün Güllü , Tai Yu-Tzu , Richardson Paul G. , Carrasco Ruben D. , Wiest Olaf , Schreiber Stuart L. , Anderson Kenneth C. , Bradner James E. 
Published: November 2016

Significance
Proteasome inhibitors show remarkable anti-multiple myeloma (MM) activity in preclinical and clinical studies. However, resistance develops in the majority of patients, and novel treatments are urgently needed. Histone deacetylase 6 (HDAC6) has been shown to mediate aggresomal protein degradation and could be a potential target for combination treatment to overcome drug resistance. Here we designed and developed an HDAC6-selective small molecule inhibitor, WT161, and used this compound to define mechanisms of anti-MM activity, both alone and in combination with proteasome inhibitors in in vitro and in vivo studies. This study has established the framework for combination treatment of HDAC6 inhibitors with proteasome inhibitors in MM and validates an in vivo quality chemical probe for broad use by the research community.
Enhanced intensity of global tropical cyclones during the mid-Pliocene warm period
Authors: Yan Qing , Wei Ting , Korty Robert L. , Kossin James P. , Zhang Zhongshi , Wang Huijun 
Published: November 2016

SignificanceTo better understand how tropical cyclones (TCs) may respond to future warming, we explore the behavior of TCs during the mid-Pliocene warm period (∼3 Ma), which shares characteristics of projected warmer climate. Our TC-permitting numerical simulations predict enhanced global-average peak TC intensity, longer duration, increased power dissipation, and a poleward migration of the location of peak intensity during the mid-Pliocene, although there are regional differences in the magnitude and statistical power of the climate/TC relationships. Our results share similarities with global TC changes observed during recent global warming and in most future projections and provide a window into the potential TC activity that may be expected in a warmer world.
Lessons from Star Carr on the vulnerability of organic archaeological remains to environmental change
Authors: High Kirsty , Milner Nicky , Panter Ian , Demarchi Beatrice , Penkman Kirsty E. H. 
Published: November 2016

Significance
Wetland deposits provide a unique repository of archaeological and environmental information, preserving organic remains rarely found elsewhere. Star Carr is an impressive example, having provided unique evidence for human interactions with the landscape at the end of the last ice age. Tragically, here we provide experimental evidence that human modifications of the local environment are leading to changes in the site’s geochemistry, resulting in the rapid loss of bone and wood artifacts. Our research demands a reassessment of the assumption that sites such as Star Carr should be preserved in situ for the benefit of future researchers and demonstrates that potential changes to the burial environment must be considered before such a policy is pursued.
In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis
Authors: Kirschbaum Klara , Sonner Jana K. , Zeller Matthias W. , Deumelandt Katrin , Bode Julia , Sharma Rakesh , Krüwel Thomas , Fischer Manuel , Hoffmann Angelika , Costa da Silva Milene , Muckenthaler Martina U. , Wick Wolfgang , Tews Björn , Chen John W. , Heiland Sabine , Bendszus Martin , Platten Michael , Breckwoldt Michael O. 
Published: November 2016

Significance
Multiple sclerosis is a devastating neurological condition that can affect the entire central nervous system. Innate immune cells mediate the underlying tissue damage, but visualizing these cellular culprits is currently not possible. Diagnosis and treatment monitoring are performed by MRI, but so far imaging markers are unspecific and based on secondary parameters (edema/gliosis; blood–brain barrier disruption). We used a nanoparticle-based approach to image brain-resident and infiltrating innate immune cells in inflammatory lesions. Nanoparticle uptake is specific for innate immune cells and correlates with clinical severity. Thus, targeting innate immunity by molecular imaging may serve as a direct marker of disease activity with the potential of clinical translation to a wide variety of inflammatory conditions for improved diagnosis and treatment monitoring.
Networks of conforming or nonconforming individuals tend to reach satisfactory decisions
Authors: Ramazi Pouria , Riehl James , Cao Ming 
Published: November 2016

Significance
Many real-life decisions where one out of two actions must be chosen can be modeled on networks consisting of individuals who are either coordinating, that is, take an action only if sufficient neighbors are also doing so, or anticoordinating, that is, take an action only if too many neighbors are doing the opposite. It is not yet known whether such networks tend to reach a state where every individual is satisfied with his decision. We show that indeed any network of coordinating, and any network of anticoordinating individuals always reaches a satisfactory state, regardless of how they are connected, how different their preferences are, and how many simultaneous decisions are made over time.
Neural correlates of specific musical anhedonia
Authors: Martínez-Molina Noelia , Mas-Herrero Ernest , Rodríguez-Fornells Antoni , Zatorre Robert J. , Marco-Pallarés Josep 
Published: November 2016

SignificanceThis study provides direct evidence supporting the model of reward–auditory cortex interaction as underlying musical pleasure: People who do not experience that pleasure have selectively reduced responses in that system. People who are especially sensitive to musical reward conversely seem to show an enhanced interaction. Our paper offers insights into the neurobiological basis of music-induced pleasure that could also provide the basis for thinking more broadly about other types of aesthetic rewards. Our results also provide an important step toward the understanding of how music may have acquired reward value through evolution.
First genealogy for a wild marine fish population reveals multigenerational philopatry
Authors: Salles Océane C. , Pujol Benoit , Maynard Jeffrey A. , Almany Glenn R. , Berumen Michael L. , Jones Geoffrey P. , Saenz-Agudelo Pablo , Srinivasan Maya , Thorrold Simon R. , Planes Serge 
Published: November 2016

SignificanceEvidence for natal philopatry, the return of individuals to their natal location for reproduction, is scarce in marine fish populations despite being common in anadromous fishes. The proportion of individuals returning to natal sites is an important metric for estimating the effects of inbreeding and the potential for local adaptation to generate resilience to climate change. Here, we present the first multigenerational pedigree for a wild marine fish. We resolved the genealogical tree of families of orange clownfishAmphiprion perculaspanning up to five generations, using data from a 10-year genetic survey of a population at Kimbe Island, Papua New Guinea. We found that longitudinal philopatry plays a significant role in driving population renewal of the orange clownfish.
Expression of HIV-1 matrix protein p17 and association with B-cell lymphoma in HIV-1 transgenic mice
Authors: Carroll Virginia A. , Lafferty Mark K. , Marchionni Luigi , Bryant Joseph L. , Gallo Robert C. , Garzino-Demo Alfredo 
Published: November 2016

SignificanceNon-Hodgkin lymphomas are associated with HIV infection. Current hypotheses on lymphomagenesis, based on immunosuppression and/or activation and/or inflammation, are generic and do not provide mechanistic, testable models. Here we show that several HIV proteins are expressed in a HIV transgenic mouse model of lymphoma, but only Matrix/p17 is consistently expressed at high levels even in early disease stages. Microarray analyses of gene expression showed an enrichment of recombination-activating genes (Rag1/2) in mouse lymphoma tissue. When activated human B cells were treated with p17, induction of RAG1 expression was observed in three of seven donors. Taken together, and in the context of the literature, our results point to the involvement of p17 in supporting B-cell growth and genetic instability.
DNA-relay mechanism is sufficient to explain ParA-dependent intracellular transport and patterning of single and multiple cargos
Authors: Surovtsev Ivan V. , Campos Manuel , Jacobs-Wagner Christine 
Published: November 2016

SignificanceAlthough intracellular patterning is crucial for cell function, the mechanisms by which spatial patterns arise often remain elusive. Here, we investigate the mechanism of intracellular patterning by the broadly conserved bacterial ParA/B systems, which drive the transport and partitioning of cellular cargos such as plasmids. We show that a simple model that considers only the known biochemical properties of the ParA and ParB proteins and the stochastic dynamics of chromosomal loci observed in vivo explains the spontaneous formation of propagating protein gradients, cargo oscillations, and equidistant patterns that are characteristic of ParA/B systems. Our study shows that stochastic processes and directionally random forces alone—without cytoskeletal elements or motor proteins—can result in directed motion and complex spatial patterning.
Warm storage for arc magmas
Authors: Barboni Mélanie , Boehnke Patrick , Schmitt Axel K. , Harrison T. Mark , Shane Phil , Bouvier Anne-Sophie , Baumgartner Lukas 
Published: November 2016

SignificanceThe increasingly popular notion that steady-state magma chambers are highly crystallized, and thus only capable of erupting during brief (<1 ka) reheatings, implies that melt detection beneath volcanoes warns of imminent eruption. By integrating the microgeochronology and geochemistry of zircons from lavas with those from components crystallized within the magma chamber and incorporated during eruption, we show that the Soufrière (Saint Lucia) volcanic reservoir was instead eruptible over long (>100 ka) timescales. Together with data from other volcanic complexes, we show that arc magmas may generally be stored warm (are able to erupt for >100 ka). Thus geophysical detection of melt beneath volcanoes represents the normal state of magma storage and holds little potential as an indicator of volcanic hazard.
Calcium sensor regulation of the Ca
V
2.1 Ca
2+
channel contributes to long-term potentiation and spatial learning
Authors: Nanou Evanthia , Scheuer Todd , Catterall William A. 
Published: November 2016

Significance
Learning and memory are caused by changes in strength of communication between neurons at synapses. Both brief changes (short-term plasticity) and long-lasting changes (long-term plasticity) are important. Synaptic transmission is initiated by calcium channels, which are regulated by calcium-sensor proteins that induce short-term synaptic plasticity. We studied genetically modified mice with a mutation in the binding site for calcium-sensor proteins on calcium channels, which alters short-term synaptic plasticity. Surprisingly, we found that synapses in the hippocampus of these mice also have impaired long-term potentiation. In addition, these mutant mice have impaired spatial learning and memory. Our results show that disruption of calcium-channel regulation by calcium-sensor proteins alters both short-term and long-term plasticity, and these changes impair spatial learning and memory.
Sensitivity of Turkish infants to vowel harmony
Authors: Hohenberger Annette , Altan Aslı , Kaya Utku , Tuncer Özgün Köksal , Avcu Enes 
Published: November 2016

Abstract
In a longitudinal study we found that 6- and 10-month-old monolingual Turkish infants are already sensitive to backness vowel harmony in stem-suffix sequences. Using a head-turn paradigm, listening times between 2 vowel-harmonic and 2 vowel-disharmonic lists of words for backness and rounding harmony were compared. While only main effects of age and trial were found for rounding harmony, in backness harmony a significant interaction between harmony and age was found: 6-month-olds preferred listening to harmonic words whereas 10-month-olds preferred listening to disharmonic words. This finding is reminiscent of the “familiarity-to-novelty-shift” in cognitive development, indicating that younger infants first extract the regular, harmonic pattern in their ambient language, whereas older infants’ attention is drawn to irregular, disharmonic tokens, due to violation-of-expectation.
Scene-setting and referent introduction in sign and spoken languages
Authors: Sümer Beyza 
Published: November 2016

Abstract
Previous studies show that children do not become adult-like in learning to set the scene and introduce referents in their narrations until 9 years of age and even beyond. However, they investigated spoken languages, thus we do not know much about how these skills are acquired in sign languages, where events are expressed in visually similar ways to the real world events, unlike in spoken languages. The results of the current study demonstrate that deaf children (3;5–9;10 years) acquiring Turkish Sign Language, and hearing children (3;8–9;11 years) acquiring spoken Turkish both acquire scene-setting and referent introduction skills at similar ages. Thus the modality of the language being acquired does not have facilitating or hindering effects in the development of these skills.
Vocabulary and grammar acquisition in Turkish as assessed by the Turkish communicative development inventory
Authors: Maviş İlknur , Demirdöğenler Selen 
Published: November 2016

Abstract
This study reports results from the recently developed Turkish Communicative Development Inventory (CDI-TR), a parental report measure to assess the vocabulary of children aged 16–36 months. In the study, 60 typically developing (TD) children between 24–36 months and 35 language-delayed (LD) monolingual Turkish-speaking children between 30–48 months were compared with regard to the size of expressive vocabulary, maximum length of utterance (M3L), and sentence complexity. The LD group lagged substantially behind the TD group for vocabulary size as measured in the number of nouns and verbs. The LD group also lagged behind the TD children for mean maximum length of utterance, for all 5 verb and 8 noun inflections and for most of the nine complex sentence structures queried.