bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and safety of polyethylene‐glycol‐4000 versus sodium picosulphate plus magnesium oxide and citric acid for bowel cleansing before colonoscopy in children: A systematic review with meta‐analysis
Authors: Furio Silvia , Lucarini Alessio , Mennini Maurizio , Strisciuglio Caterina , Felici Enrico , Ferretti Alessandro , Parisi Pasquale , D'Angelo Francesco , Marasco Giovanni , Barbara Giovanni , Ricciardi Luca , Piccirillo Marisa , Di Nardo Giovanni 
Published: October 2024

AbstractColonoscopy is performed for diagnostic and therapeutic purposes. The quality of colonoscopy depends on adequate bowel cleansing. However, there is no standardized protocol for bowel preparation in children. We conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs) to estimate the effectiveness, safety, and tolerability profile of polyethylene glycol (PEG) compared with those of sodium picosulfate magnesium citrate (SPMC) in children. The primary sources of the reviewed studies were Scopus, PubMed, and Cochrane Library. The databases were systematically searched for RCTs comparing PEG 4000 to SPMC as a bowel cleansing solution. Six studies were included. The analysis showed that both PEG and SPMC are effective for bowel cleansing, while a split‐dose regimen may be preferable to a day‐before one. There were no differences between the two groups regarding adverse events (AEs) such as abdominal pain, nausea, vomiting, bloating, and anal discomfort. Additionally, preparation with SPMC was preferred in terms of acceptability and compliance. Still, the need to place a nasogastric tube was significantly lower in the SPMC group compared to the PEG group and in the split dose regimen compared to the day before. In conclusion, PEG and SPMC are equally effective in obtaining an adequate bowel cleansing with a comparable AE rate; moreover, split‐dose administration may be preferable to day‐before one in terms of effective bowel cleansing. However, SPMC preparation is more acceptable seems to result in higher compliance, and to reduce the use of a nasogastric tube, that we encounter daily in clinical practice, is perceived as a stressful experience for children and their families.
Recent Trends in Therapeutic Drug Monitoring of Peptide Antibiotics
Authors: Kilianova Zuzana , Cizmarova Ivana , Spaglova Miroslava , Piestansky Juraj 
Published: October 2024

ABSTRACTAntimicrobial peptides take a specific position in the field of antibiotics (ATBs), however, from a large number of available molecules only a few of them were approved and are used in clinics. These therapeutic modalities play a crucial role in the management of diseases caused by multidrug‐resistant bacterial pathogens and represent the last‐line therapy for bacterial infections. Therefore, there is a demand for a rationale use of such ATBs based on optimization of the dosing strategy to minimize the risk of resistance and ensure the sustainable efficacy of the drug in real clinical practice. Therapeutic drug monitoring, as a measurement of drug concentration in the body fluids or tissues, results in the optimization of the patient´s medication and therapy outcome. This strategy is beneficial and could result in tailored therapy for different types of infection and the prolongation of the use and efficacy of ATBs in hospitals. This review paper provides an actual overview of approved antimicrobial peptides used in clinical practice and covers current trends in their analysis by convenient and advanced methodologies used for their identification and/or quantitation in biological matrices for therapeutic drug monitoring purposes. Special emphasis is given to the methods with perspective clinical outcomes.
Barn owl site occupancy and breeding success in relation to land use and nest box characteristics
Authors: Milliet Estelle , Schalcher Kim , Grangier‐Bijou Anna , Almasi Bettina , Butera Fabrizio , Roulin Alexandre 
Published: October 2024

AbstractAgricultural landscapes play a crucial role in enhancing biodiversity because of their widespread presence over the Earth and their ability to encompass diverse ecosystems. Recognizing this, numerous governments are incentivizing farmers through direct payments to adopt sustainable practices, such as managing extensive pastures and meadows, planting wildflowers, or establishing hedgerows. However, the benefit of such sustainable practices on vertebrate species is not well understood. From 2018 to 2020, we investigated nest occupancy, fledging success, and clutch size of a Swiss population of barn owls (Tyto alba) with respect to nest box characteristics and the presence of extensive agriculture and urbanization in areas surrounding nest boxes. Our results revealed that extensively used pastures were negatively associated with site occupancy but positively associated with clutch size. The proportion of urban areas was negatively related to both site occupancy and clutch size. The altitude of the nest box location was negatively correlated with occupancy, and the number of nest boxes placed at the same site (either 1 or 2) was positively correlated with site occupancy. Moreover, clutch size, but not fledging success, was larger in nest boxes placed outside barns than in nest boxes placed inside barns. Based on these findings, we recommend installing nest boxes at locations <700 m in altitude and in pairs on the same barn, incorporating biodiversity promotion areas into agricultural landscapes, and avoiding dense urban areas in favor of rural zones with lower urban density. Understanding the nuanced relationships between nest box characteristics, environmental factors, and breeding success provides valuable insights for optimizing artificial nesting sites and enhancing the overall reproductive success of barn owls.
Systemic Effects and Absorption of Subepithelial Dexamethasone Vocal Fold Injections
Authors: Alwan Mostafa , Phyland Debra J. , Smith Julian A. , Paddle Paul M. 
Published: October 2024

Objective/HypothesisTo compare the systemic changes following two office‐based procedures—subepithelial vocal fold steroid injections (VFSI) and vocal fold augmentation (VFA), and to characterize the magnitude and chronicity of the effects observed.Study DesignProspective, controlled before‐after comparative study.MethodsPatients prospectively underwent VFSI with 0.8–2 mg of dexamethasone or VFA. Serum cortisol, white cell count (WCC), and C‐reactive protein (CRP) were measured at day 0 (pre‐procedure), 1 and 7. Salivary cortisol was measured at baseline and daily for 7 days post‐procedure.ResultsFourteen patients underwent VFSI and 36 VFA. At baseline serum cortisol measured 304.6 ± 116.6 nmol/L and fell significantly to 48.1 ± 41.8 nmol/L 1 day following dexamethasone injection (p = 0.001) and recovered by day 7 to 303.7 ± 78.7 nmol/L. Salivary cortisol demonstrated a similar pattern with significant recovery demonstrated by day 3 (p = 0.001). White cell counts were affected by the systemic absorption of exogenous steroid and normalized by day 7. Patients who underwent VFA demonstrated no significant change in their serum or salivary cortisol and no significant change in their WCC. No significant changes in CRP or patient's physiological parameters were observed in either procedure.ConclusionOur findings demonstrate systemic absorption of dexamethasone following VFSI, with acute hypothalamic‐pituitary‐adrenal (HPA) axis suppression which normalizes day 3 post‐procedurally.Level of Evidence3 Laryngoscope, 135:801–808, 2025
Quantifying Soil Loss in the Brazilian Savanna Ecosystem: Current Rates and Anticipated Impact of Climate Changes
Authors: Schwamback Dimaghi , Amorim Brandão Abderraman R. , Bertotto Luis Eduardo , Berndtsson Ronny , Zhang Linus , Wendland Edson , Persson Magnus 
Published: October 2024

ABSTRACTThe Brazilian Savanna (Cerrado) is the second‐largest South American biome that corresponds to almost two‐third of the national agricultural production. Extensive agricultural‐driven land‐use changes have significantly altered the landscape, causing increased soil erosion. Furthermore, projections of climate change effects on the Cerrado raise concerns about the potential exacerbation of soil loss and its consequences on ecosystem sustainability. This study investigated soil loss for the Cerrado ecosystem by assessing current rates and projecting the potential effects of future climate change. Current soil loss was based on experimental plots (100 m2) during 7 years maintained under typical main land cover in Brazil (sugarcane, pasture, Cerrado, and bare soil). Erosivity, by using the Universal Soil Loss Equation (USLE), was estimated from observations, parameters of erodibility, and land cover. To assess the future soil loss (2100), we used the calibrated USLE equation with yearly erosivity derived from 12 downscaled and bias‐corrected SSP2‐4.5 and SSP5‐8.5 scenarios of CMIP6 climate model projections. Current agricultural practices induce considerable erosion, where sugarcane has 3.4 times higher soil loss as compared with the natural soil cover. Regarding future SSP2‐4.5 and SSP5‐8.5 scenarios (2100), we estimated an increase of 4.9% and 7.6% in soil loss, respectively, for all land covers. The observed soil loss rates underscore the critical importance of implementing sustainable land management practices to mitigate further soil degradation. Climate change may impose additional stress on the Cerrado ecosystem, amplifying the urgency for adaptive measures to safeguard this important biome.
A Facile Strategy for PEGylated Nanoprodrug of Bortezomib with Improved Stability, Enhanced Biocompatibility, pH‐Controlled Disassembly, and Release
Authors: Fu Naikuan , Zeng Yinan , Zhang Jing , Zhang Peng , Zhang Hong , Yang Shicheng , Zhang Jianhua 
Published: October 2024

AbstractThe therapeutic efficacy of bortezomib (BTZ) is often limited due to low solubility, poor stability in vivo and nonspecific toxicity. Herein, a kind of catechol‐functionalized polyethylene glycol (mPEG‐CA) is first synthesized and then mPEG‐CA is readily used to conjugate with BTZ by the formation of dynamic boronate bonds to obtain PEGlyated BTZ prodrug (mPEG‐CA‐BTZ) with the ability of pH‐controlled disassembly and drug release. The structure and morphology, physicochemical characteristics, drug loading, and release as well as in vitro cytotoxicity of mPEG‐CA‐BTZ nanoparticles are investigated in detail. The results demonstrated that mPEG‐CA‐BTZ can not only self‐assemble into nanostructures with uniform size and stable dispersion in physiological pH condition (pH 7.4) but also respond to the tumor acid microenvironment and achieve pH‐controlled BTZ release by acid‐triggered cleavage of boronate bonds, decomposition of mPEG‐CA‐BTZ and thus disassembly of mPEG‐CA‐BTZ nanoparticles. mPEG‐CA‐BTZ nanoparticles are expected to have great potential as a promising nanoplatform for pharmaceutical formulations of BTZ to increase therapeutic efficacy and decrease side effects of BTZ. Considering the easily available and biocompatible excipients and simple preparation process, the strategy designed herein provides a facile and promising approach to synergistically integrate the function of PEGylation and pH‐sensitiveness into boronic acid‐containing small molecule pharmaceutical agents.
Progress on the Sound Absorption of Viscoelastic Damping Porous Polymer Composites
Authors: Tang Xiaoning 
Published: October 2024

AbstractPorous polymer composites (PPC) have developed rapidly recently, which are widely used in various industrial fields. Viscoelastic damping is an important behavior of porous polymer composites, and it can determine the sound absorption for noise reduction applications. This review has mainly covered the viscoelastic damping and sound absorption of porous polymer composites. Different fabrication approaches of porous polymer composites are gathered. The mechanism of viscoelastic damping behavior is described, and also the sound absorption properties. Followed by the introduction of enhanced sound absorption of viscoelastic damping porous polymer composites, including the incorporation of fillers, microstructures modification, combination with nanofibrous materials, and multilayer configuration, etc. The incorporated fillers can effectively adjust the interfacial area in composites, and obtain desired bonding conditions. Microstructures modification is an effective tool to improve the morphologies of both polymer matrix and fillers, which can be achieved by chemical treatment and surface coating. The combination with lightweight nanofibrous layer can increase the low frequency absorption. The configuration of multilayer composites can improve both acoustical and mechanical properties for engineering applications. It is hoped that this comprehensive review is benefit for the promising development of porous polymer composites in related fields.
Dynamic Micelle‐Hydrogels for 3D‐Architected Transition Metal Sulfides
Authors: Wang Zhenzhen , Zhou Xiaozhuang , Wu Junen , Wei Yimeng , Cui Yubo , Xia Yulong , Xu Weiming , Mu Shichun , Cui Jiaxi 
Published: October 2024

AbstractAdditive manufacturing of transition metal sulfides (TMS) enables the creation of complex 3D structures, significantly expanding their applications. However, preparing 3D‐structured TMS remains challenging due to difficulties in developing suitable inks. In this study, a supramolecular micelle hydrogel as the ink to fabricate 3D‐structured TMS is utilized. Initially, the hydrogels are printed and infused with metal salt solutions to stabilize the structures, which are then calcined to convert into miniaturized 3D‐TMS replicas. The micellar hydrogels crosslink via hydrophobic interactions, with sodium dodecyl sulfonate (SDS) micelles providing both a hydrophobic environment and sulfur sources. During calcination, the decomposed sulfur precursors coordinate with metal ions to form various TMS, including FeS2, Cu2S, Ni3S2, and Co9S8, along with several metal sulfides like PbS and SnS. Additionally, the method also allows for the preparation of transition metal dichalcogenides such as MoS2 and WS2. The formation mechanism is demonstrated using Ni3S2 as an example which exhibits notable catalytic activity in oxygen evolution reactions (OER) and hydrogen evolution reactions (HER). Given its simplicity and versatility, this dynamic micellar hydrogel‐derived strategy offers a promising pathway for creating advanced TMS materials.
Cognitive Impact of β‐Amyloid Load in the Rapid Eye Movement Sleep Behavior Disorder–Lewy Body Disease Continuum
Authors: Woo Kyung Ah , Yoon Eun Jin , Kim Seoyeon , Kim Heejung , Kim Ryul , Jin Bora , Lee Seungmin , Park Hyunwoong , Nam Hyunwoo , Kim Yu Kyeong , Lee Jee‐Young 
Published: October 2024

AbstractBackgroundRapid eye movement sleep behavior disorder (RBD) is linked to the diffuse‐malignant subtype and higher cognitive burden in Lewy body disease (LBD).ObjectiveThis study explores brain β‐amyloid deposition and its association with cognitive decline across the RBD–LBD continuum.MethodsPatients with isolated RBD (iRBD), Parkinson's disease with probable RBD (PDRBD), and dementia with Lewy bodies with probable RBD (DLBRBD) underwent 18F‐florbetaben positron emission tomography, 3T magnetic resonance imaging scans, and comprehensive neuropsychological assessments. Subjects were categorized as cognitively normal (NC), mild cognitive impairment (MCI), or dementia. Global and regional standardized uptake value ratios (SUVR) were estimated in predefined cognitive volumes of interest (VOI) derived from voxel‐wise comparison analysis among the cognitive groups, namely the prefrontal, parietal, precentral cortices, lingual gyrus, and supplementary motor area. Generalized linear models assessed the relationship between 18F‐florbetaben SUVRs and neuropsychological testing, adjusting for age and sex. Subgroup analysis focused on the polysomnography‐confirmed iRBD‐continuum subset (n = 41) encompassing phenoconverters and nonconverters in our prospective iRBD cohort.ResultsEighty‐six subjects were classified as follows: 14 NC, 54 MCI, and 18 dementia. The proportion of positive β‐amyloid scans increased with advanced cognitive stages (P = 0.038). β‐Amyloid signals in cognitive VOIs were elevated in subgroups showing impairment in Trail‐Making Test B (TMT‐B). A linear association between TMT‐B z score and global cortical β‐amyloid levels was observed in the iRBD‐continuum subset (P = 0.013).ConclusionCortical β‐amyloid accumulates with declines in executive function within the RBD–LBD continuum. TMT‐B performance may be a useful marker associating with β‐amyloid load, particularly in the iRBD population. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Identification of Pathogenic Copy Number Variants in Mexican Patients With Inherited Retinal Dystrophies Applying an Exome Sequencing Data‐Based Read‐Depth Approach
Authors: Fabian‐Morales Gerardo E. , Ordoñez‐Labastida Vianey , Garcia‐Martínez Froylan , Montes‐Almanza Luis , Zenteno Juan C. 
Published: October 2024

ABSTRACTBackgroundRetinal dystrophies (RDs) are the most common cause of inherited blindness worldwide and are caused by genetic defects in about 300 different genes. While targeted next‐generation sequencing (NGS) has been demonstrated to be a reliable and efficient method to identify RD disease‐causing variants, it doesn't routinely identify pathogenic structural variant as copy number variations (CNVs). Targeted NGS‐based CNV detection has become a crucial step for RDs molecular diagnosis, particularly in cases without identified causative single nucleotide or Indels variants. Herein, we report the exome sequencing (ES) data‐based read‐depth bioinformatic analysis in a group of 30 unrelated Mexican RD patients with a negative or inconclusive genetic result after ES.MethodsCNV detection was performed using ExomeDepth software, an R package designed to detect CNVs using exome data. Bioinformatic validation of identified CNVs was conducted through a commercially available CNV caller. All identified candidate pathogenic CNVs were orthogonally verified through quantitative PCR assays.ResultsPathogenic or likely pathogenic CNVs were identified in 6 out of 30 cases (20%), and of them, a definitive molecular diagnosis was reached in 5 cases, for a final diagnostic rate of ~17%. CNV‐carrying genes included CLN3 (2 cases), ABCA4 (novel deletion), EYS, and RPGRIP1.ConclusionsOur results indicate that bioinformatic analysis of ES data is a reliable method for pathogenic CNV detection and that it should be incorporated in cases with a negative or inconclusive molecular result after ES.
Rehabilitation Interventions for Adults With Complex Regional Pain Syndrome: A Scoping Review Protocol
Authors: Pique Batalla Marc A. , Van de Winckel Ann , Walsh Nicola E. , Lewis Jennifer S. 
Published: October 2024

ABSTRACTObjectivesThis scoping review will explore the literature related to rehabilitation interventions for the treatment of adults living with complex regional pain syndrome (CRPS), describe the domains and outcome measures used to assess their effectiveness, and examine the neurophysiological bases of these interventions.IntroductionThe unremitting symptoms of CRPS, a chronic pain condition, are associated with long‐term disability, poor psychological health, decreased emotional and social well‐being, and reduced quality of life. Effective treatment for persistent symptoms is notoriously difficult. Therapeutic approaches such as graded motor imagery or pain exposure therapy are recommended for CRPS but show mixed results, insufficient effectiveness, variability in outcome measures, and unclear neurophysiological bases.Inclusion CriteriaThis review will consider studies that include any form of non‐invasive rehabilitation intervention delivered by a healthcare professional in any setting for adults with a CRPS diagnosis. Quantitative, qualitative and observational studies, text and opinion papers will be considered.MethodsThe Joanna Briggs Institute (JBI) methodology will be used to conduct this scoping review. MEDLINE, Embase, Scopus, APA PsycINFO, CINAHL, Cochrane, OpenGrey Google and ProQuest Dissertations and Theses Global (ProQuest) will be searched for studies in English published between 2007 and 2024. Two independent reviewers will screen the titles, abstracts, and full texts of the selected studies. Data collection will be performed using a tool developed by the researchers based on the standardised JBI tool. Data will be presented in a comprehensive narrative summary.Trail Registration: https://doi.org/10.17605/OSF.IO/P967T
Decoding visceral adipose tissue molecular signatures in obesity and insulin resistance: a multi‐omics approach
Authors: Roy Dipayan , Ghosh Raghumoy , Ghosh Ritwik , Khokhar Manoj , Naing Ma Yin Yin , Benito‐León Julián 
Published: October 2024

AbstractObjectiveObesity‐associated insulin resistance (IR) is responsible for considerable morbidity and mortality globally. Despite vast genomic data, many areas, from pathogenesis to management, still have significant knowledge gaps. We aimed to characterize visceral adipose tissue (VAT) in obesity and IR through a multi‐omics approach.MethodsWe procured data on VAT samples from the Gene Expression Omnibus (GEO) for the following two groups: 1) populations with obesity (n = 34) versus those without (n = 26); and 2) populations with obesity and IR (n = 15) versus those with obesity but without IR (n = 15). Gene set enrichment, protein‐protein interaction network construction, hub gene identification, and drug‐gene interactions were performed, followed by regulatory network prediction involving transcription factors (TFs) and microRNAs (miRNAs).ResultsInterleukin signaling pathways, cellular differentiation, and regulation of immune response revealed a significant cross talk between VAT and the immune system. Other findings include cancer pathways, neurotrophin signaling, and aging. A total of 10 hub genes, i.e., STAT1, KLF4, DUSP1, EGR1, FOS, JUN, IL2, IL6, MMP9, and FGF9, 24 TFs, and approved hub gene‐targeting drugs were obtained. A total of 10 targeting miRNAs (e.g., hsa‐miR‐155‐5p, hsa‐miR‐34a‐5p) were associated with obesity and IR‐related pathways.ConclusionsOur multi‐omics integration method revealed hub genes, TFs, and miRNAs that can be potential targets for investigation in VAT‐related inflammatory processes and IR, therapeutic management, and risk stratifications.image