bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pain and hospital admissions are important factors associated with quality of life in nonambulatory children
Authors: Elema Agnes , Zalmstra Trees A. L. , Boonstra Anne M. , Narayanan Unni G. , Reinders‐Messelink Heleen A. , v. d. Putten Annette A. J. 
Published: June 2016

AbstractAimThis was the first study to investigate the factors associated with health‐related quality of life (HRQoL) in nonambulatory children with cerebral palsy (CP), based on a HRQoL measure specifically developed for this population.MethodsThe Dutch version of the Caregiver Priorities and Child Health Index of Life with Disabilities (CPCHILD‐DV) was used to measure HRQoL. It was completed by 66 parents of 47 boys and 19 girls with nonambulatory CP aged between five and 18 years with gross motor function classification system (GMFCS) levels of IV and V. Factors measured were the child's motor and cognitive impairments, comorbidities, pain, parents' education and occupations and family structure. Multiple linear regression analyses were used to determine the significant factors and the relative contribution of these factors to the CPCHILD‐DV scores.ResultsThe most important factors associated with poorer HRQoL scores were pain and hospital admissions in the previous six months. Other factors were as follows: increased GMFCS level, feeding by gastrostomy tube, inability to communicate verbally, cognitive impairment, poor seizure control and higher parents' educational qualifications.ConclusionPain and hospital admissions were the most important factors that were negatively associated with HRQoL in nonambulatory children with CP between five to 18 years.
Business Actors in Peace Mediation Processes
Authors: Iff Andrea , Alluri Rina M. 
Published: June 2016

AbstractEven though the relevance of business actors in peace processes is increasingly acknowledged, analysis of their particular roles and contributions remain sparse in peace mediation literature. This is despite the fact that such knowledge would be highly relevant for supporting mediation processes such as those ongoing in Colombia or the Philippines. This article looks at the involvement of business actors in mediation processes by tracing analysis along the entry points for involvement, the different roles that business actors can play and the limitations they face. The empirical data shows that business actors mainly play a role during the pre‐ and mediation phase and therein often as a support‐giver to the mediation process. Furthermore, most of the involvement does not take place at track‐1 level but rather at track‐2 mediation processes, where mainly local business play an important role. In contrary to what is postulated by some of the literature, the relevance of utilitaristic motives is not problematic; rather a monetary motivation can also foster the credibility in a political process where a lot is at stake.
Discourses about Righting the Business ← → Society Relationship
Authors: Fyke Jeremy P. , Feldner Sarah Bonewits , May Steven K. 
Published: June 2016

AbstractThis article engages the question—what is the right business‐society relationship? We consider three perspectives that seek to address the relationship: corporate social responsibility (CSR), social entrepreneurship (SE), and conscious capitalism (CC). We take a macroapproach considering how commentary about these approaches establishes a direction for corporate practice and its relationship to key stakeholder groups. We argue that these perspectives are ‘D'iscourses that provide arguments for and articulations about the direction of corporate practice and the business‐society relationship. To organize our review of each perspective, and focus our critique, for each we highlight (a) drivers and influencers, (b) core assumptions and defining features, and (c) approaches and exemplars. Although distinct, all emphasize effective business practices as key to meeting social needs. CSR suggests legitimizing business practice; SE relocates business practices; and CC seeks to reimagine/rehabilitate business for social good. Ultimately, we conclude that these Discourses lack a clear communicative focus in terms of decision making within these organizations. We attend to this and other implications, and offer avenues for further research.
Corporate Social Responsibility Reporting as Substantive and Symbolic Behavior: A Multilevel Theoretical Analysis
Authors: Shabana Kareem M. , Ravlin Elizabeth C. 
Published: June 2016

AbstractThis article describes a multilevel theoretical framework that examines the multiple causes of corporate social responsibility (CSR) reporting in the social environment of business. We argue that substantive and/or symbolic reporting flows from individual‐, aggregate‐, organizational‐, and institution‐level phenomena, and is thus a complex outcome of CSR and corporate social performance (CSP). Theoretical lenses range from reinforcement theory at the microlevel to legitimacy and stakeholder theories at the macrolevel, and include a discussion of the emergence of lower‐level CSR‐relevant characteristics to higher level constructs. Our goal is to clarify how this behavior develops from microlevel, mesolevel, and macrolevel processes with a view toward assisting corporations to better enact CSR reporting, and their stakeholders to effectively promote substantive reporting behavior.
Clusterin levels are increased in Alzheimer's disease and influence the regional distribution of Aβ
Authors: Miners J. Scott , Clarke Polly , Love Seth 
Published: June 2016

AbstractClusterin, also known as apoJ, is a lipoprotein abundantly expressed within the CNS. It regulates Aβ fibril formation and toxicity and facilitates amyloid‐β (Aβ) transport across the blood‐brain barrier. Genome‐wide association studies have shown variations in the clusterin gene (CLU) to influence the risk of developing sporadic Alzheimer's disease (AD). To explore whether clusterin modulates the regional deposition of Aβ, we measured levels of soluble (NP40‐extracted) and insoluble (guanidine‐HCl‐extracted) clusterin, Aβ40 and Aβ42 by sandwich ELISA in brain regions with a predilection for amyloid pathology—mid‐frontal cortex (MF), cingulate cortex (CC), parahippocampal cortex (PH), and regions with little or no pathology—thalamus (TH) and white matter (WM). Clusterin level was highest in regions with plaque pathology (MF, CC, PH and PC), approximately mirroring the regional distribution of Aβ. It was significantly higher in AD than controls, and correlated positively with Aβ42 and insoluble Aβ40. Soluble clusterin level rose significantly with severity of cerebral amyloid angiopathy, and in MF and PC regions was highest in APOE ɛ4 homozygotes. In the TH and WM (areas with little amyloid pathology) clusterin was unaltered in AD and did not correlate with Aβ level. There was a significant positive correlation between the concentration of clusterin and the regional levels of insoluble Aβ42; however, the molar ratio of clusterin : Aβ42 declined with insoluble Aβ42 level in a region‐dependent manner, being lowest in regions with predilection for Aβ plaque pathology. Under physiological conditions, clusterin reduces aggregation and promotes clearance of Aβ. Our findings indicate that in AD, clusterin increases, particularly in regions with most abundant Aβ, but because the increase does not match the rising level of Aβ42, the molar ratio of clusterin : Aβ42 in those regions falls, probably contributing to Aβ deposition within the tissue.
Prostate cancer characteristics and outcome in renal transplant recipients: results from a contemporary single center study
Authors: Pettenati Caroline , Jannot Anne‐Sophie , Hurel Sophie , Verkarre Virginie , Kreis Henri , Housset Martin , Legendre Christophe , Méjean Arnaud , Timsit Marc‐Olivier 
Published: June 2016

AbstractBackgroundProstate cancer (PCa) incidence is expected to increase in renal transplant recipients (RTR) with no clear nor contemporary data on management and oncological outcome.MethodsWe conducted a retrospective single center study of RTR diagnosed with PCa after transplantation between 2000 and 2013. Demographics, PCa characteristics, and treatment were assessed. For each RTR in radical prostatectomy (RP) subset, we included 4 non‐organ transplant patients who underwent RP by the same surgeons, and compared pre‐operative and post‐operative oncological features, and biochemical recurrence (BCR) rate.ResultsTwenty‐four RTR were included (PCa incidence 1.5%). Mean follow‐up was 47 months. PCa was mostly localized (n=21, 87.5%) with treatments including RP (n=16, 76.2%), brachytherapy (n=3, 14.3%), radiation therapy (n=1, 4.7%), and active surveillance (n=1, 4.7%). No graft loss due to PCa treatment was reported. Nineteen RTR with localized PCa (90.5%) were free from BCR. Considering RP subset, no difference in PCa characteristics at diagnosis and BCR rate was found between RTR (n=16) and control patients (n=64).ConclusionsLocalized PCa following renal transplantation was not associated with adverse features as compared with non‐transplant patients. Standard treatments could be proposed to RTR with satisfying results both on oncological outcome and graft function.
RANKL expression is a useful marker for differentiation of pagetoid squamous cell carcinoma in situ from extramammary Paget disease
Authors: Fujimura Taku , Kambayashi Yumi , Kakizaki Aya , Furudate Sadanori , Aiba Setsuya 
Published: June 2016

BackgroundPagetoid squamous cell carcinoma in situ (SCCIS) is a histopathologic variant of SCCIS composed of cells that display an abundant, pale‐staining cytoplasm in a pagetoid distribution within the epidermis. As pagetoid SCCIS is sometimes difficult to differentiate from extramammary Paget disease (EMPD) histopathologically, specific markers for pagetoid SCCIS or EMPD are needed by dermatopathologists.MethodsIn this report, we employed immunohistochemical staining for receptor of activated nuclear factor kappa ligand (RANKL) and programmed death‐ligand 1 (PD‐L1) in six cases each of pagetoid SCCIS and EMPD.ResultsThe Paget cells strongly expressed RANKL in EMPD, whereas the atypical keratinocytes did not express RANKL in any of the six cases of pagetoid SCCIS. In all cases of pagetoid SCCIS, atypical keratinocytes expressed PD‐L1. In EMPD, Paget cells expressed PD‐L1 in half of the cases at a lower level of expression than was seen in the surrounding keratinocytes.ConclusionThis study suggested that RANKL, but not PD‐L1, could be a marker to differentiate between pagetoid SCCIS and EMPD.
How variation between individuals affects species coexistence
Authors: Hart Simon P. , Schreiber Sebastian J. , Levine Jonathan M. 
Published: June 2016

AbstractAlthough the effects of variation between individuals within species are traditionally ignored in studies of species coexistence, the magnitude of intraspecific variation in nature is forcing ecologists to reconsider. Compelling intuitive arguments suggest that individual variation may provide a previously unrecognised route to diversity maintenance by blurring species‐level competitive differences or substituting for species‐level niche differences. These arguments, which are motivating a large body of empirical work, have rarely been evaluated with quantitative theory. Here we incorporate intraspecific variation into a common model of competition and identify three pathways by which this variation affects coexistence: (1) changes in competitive dynamics because of nonlinear averaging, (2) changes in species’ mean interaction strengths because of variation in underlying traits (also via nonlinear averaging) and (3) effects on stochastic demography. As a consequence of the first two mechanisms, we find that intraspecific variation in competitive ability increases the dominance of superior competitors, and intraspecific niche variation reduces species‐level niche differentiation, both of which make coexistence more difficult. In addition, individual variation can exacerbate the effects of demographic stochasticity, and this further destabilises coexistence. Our work provides a theoretical foundation for emerging empirical interests in the effects of intraspecific variation on species diversity.
Multidimensional biases, gaps and uncertainties in global plant occurrence information
Authors: Meyer Carsten , Weigelt Patrick , Kreft Holger 
Published: June 2016

AbstractPlants are a hyperdiverse clade that plays a key role in maintaining ecological and evolutionary processes as well as human livelihoods. Biases, gaps and uncertainties in plant occurrence information remain a central problem in ecology and conservation, but these limitations remain largely unassessed globally. In this synthesis, we propose a conceptual framework for analysing gaps in information coverage, information uncertainties and biases in these metrics along taxonomic, geographical and temporal dimensions, and apply it to all c. 370 000 species of land plants. To this end, we integrated 120 million point‐occurrence records with independent databases on plant taxonomy, distributions and conservation status. We find that different data limitations are prevalent in each dimension. Different metrics of information coverage and uncertainty are largely uncorrelated, and reducing taxonomic, spatial or temporal uncertainty by filtering out records would usually come at great costs to coverage. In light of these multidimensional data limitations, we discuss prospects for global plant ecological and biogeographical research, monitoring and conservation and outline critical next steps towards more effective information usage and mobilisation. Our study provides an empirical baseline for evaluating and improving global floristic knowledge, along with a conceptual framework that can be applied to study other hyperdiverse clades.
Parasites observed in the proximal alimentary tract of a Przewalski's horse in China
Authors: Liu S.‐H. , Hu D.‐F. , Li K. 
Published: June 2016

SummaryThis article reports a Przewalski's horse from the Kalamaili Nature Reserve (KNR) in China transported to our institute to determine the cause of death. The animal had been subjected to necropsy before being transported to our institute; the entire digestive tract was removed but not opened to reduce the possible loss of parasites. During examination, ascarids in the intestines and bots in the oral cavity and stomach were observed. The parasites were identified according to an identification key and enumerated. The ascarids were identified as Parascaris spp. and were associated with a volvulus, resulting in intestinal obstruction. A total of two (stomach), one (duodenum) and 106 (intestines) Parascaris spp. were counted. Bots in the digestive tract were identified as third stage larvae of Gasterophilus pecorum (G. pecorum), Gasterophilus nigricornis (G. nigricornis) and Gasterophilus nasalis (G. nasalis), which may have been associated with stomach ulcers suffered by the horse. Attached to the lining of the oral cavity and stomach were 331 and 2014, respectively, larvae of G. pecorum, while in the duodenum there were 23 third stage larvae of G. nigricornis and 20 third stage larvae of G. nasalis. Therefore, the possibility of the presence of these parasites should not be overlooked in Przewalski horses as these parasites may be responsible for severe clinical signs in infected animals.
Experimental test of the ecosystem impacts of the keystone predator Triops cancriformis (Branchiopoda: Notostraca) in temporary ponds
Authors: Waterkeyn Aline , Grillas Patrick , Brendonck Luc 
Published: June 2016

Summary

Keystone species can influence an ecosystem through a series of trophic (both direct and indirect) and non‐trophic effects. In temporary ponds, tadpole shrimps were recently identified as keystone predators, but the full extent of their ecosystem impact is still poorly known.

Using a large‐scale mesocosm experiment, we quantified the impact of different Triops cancriformis densities on ecosystem properties: water quality (including chlorophyll a as measure for phytoplankton biomass) and the diversity and structure of macrophyte and zooplankton communities. Mesocosms of 400 L (1 m2 surface) were lined with natural pond sediment of two study ponds differing in their natural Triops densities (Triops‐rich and Triops‐poor pond) and inundated to allow hatching from the egg bank. Afterwards, four Triops density treatments were established in the mesocosms: 0 (control), 5, 25 and 100 Triops per m2.

After 13 weeks, the two highest Triops densities significantly influenced the ecosystem functioning not only by triggering changes in the diversity and composition of the pond communities but also by affecting water quality through bioturbation.

These results confirm that tadpole shrimp can function as ecosystem engineers in temporary ponds and could promote a shift from a clear water to a turbid state through a series of trophic and non‐trophic level effects.
Fatty‐acid profiles of juvenile lake trout reflect experimental diets consisting of natural prey
Authors: Happel Austin , Stratton Logan , Pattridge Robert , Rinchard Jacques , Czesny Sergiusz 
Published: June 2016

Summary

It is relatively well‐known that fatty‐acid profiles of consumers reflect their diets. However, with fish, controlled studies that trace fatty‐acid profiles of natural prey into consumers are lacking. We asked whether lake trout (Salmonidae: Salvelinus namaycush) fatty‐acid profiles reflect diets at 4, 8 or 14 weeks after feeding began. We also evaluated if calibration coefficients were similar for each diet, a key assumption of quantitative fatty‐acid signature analysis (QFASA).

In this study, juvenile lake trout were fed commercially available frozen diets of chironomids (Chironomidae: Chironomus spp.), copepods (Cyclopoida spp.), or Mysis (Mysidae: Mysis relicta) over a 14‐week period.

Accurate classification of lake trout into a priori diet groups was attained after 8 weeks of feeding. Calibration coefficients were significantly different among diet groups, especially for lake trout that were fed chironomids, suggesting that diet‐specific modifications to fatty acids occurred. Chironomid‐fed lake trout grew significantly larger than others despite consuming prey that lacked long‐chain essential fatty acids. Furthermore, chironomid‐fed lake trout provide evidence for the conversion of 18:3n‐3 into longer chain n‐3 fatty acids.

Our results call for additional studies to better understand how fatty acids reflect dietary origins prior to employing QFASA on wild freshwater fishes. QFASA could provide accurate diet estimates for freshwater fishes with low‐diversity diet compositions, if calibration coefficients for each predator–prey relationship are incorporated.
The dark side of street lighting: impacts on moths and evidence for the disruption of nocturnal pollen transport
Authors: Macgregor Callum J. , Evans Darren M. , Fox Richard , Pocock Michael J. O. 
Published: June 2016

AbstractAmong drivers of environmental change, artificial light at night is relatively poorly understood, yet is increasing on a global scale. The community‐level effects of existing street lights on moths and their biotic interactions have not previously been studied. Using a combination of sampling methods at matched‐pairs of lit and unlit sites, we found significant effects of street lighting: moth abundance at ground level was halved at lit sites, species richness was >25% lower, and flight activity at the level of the light was 70% greater. Furthermore, we found that 23% of moths carried pollen of at least 28 plant species and that there was a consequent overall reduction in pollen transport at lit sites. These findings support the disruptive impact of lights on moth activity, which is one proposed mechanism driving moth declines, and suggest that street lighting potentially impacts upon pollination by nocturnal invertebrates. We highlight the importance of considering both direct and cascading impacts of artificial light.
Climate change impacts on wildlife in a High Arctic archipelago – Svalbard, Norway
Authors: Descamps Sébastien , Aars Jon , Fuglei Eva , Kovacs Kit M. , Lydersen Christian , Pavlova Olga , Pedersen Åshild Ø. , Ravolainen Virve , Strøm Hallvard 
Published: June 2016

AbstractThe Arctic is warming more rapidly than other region on the planet, and the northern Barents Sea, including the Svalbard Archipelago, is experiencing the fastest temperature increases within the circumpolar Arctic, along with the highest rate of sea ice loss. These physical changes are affecting a broad array of resident Arctic organisms as well as some migrants that occupy the region seasonally. Herein, evidence of climate change impacts on terrestrial and marine wildlife in Svalbard is reviewed, with a focus on bird and mammal species. In the terrestrial ecosystem, increased winter air temperatures and concomitant increases in the frequency of ‘rain‐on‐snow’ events are one of the most important facets of climate change with respect to impacts on flora and fauna. Winter rain creates ice that blocks access to food for herbivores and synchronizes the population dynamics of the herbivore–predator guild. In the marine ecosystem, increases in sea temperature and reductions in sea ice are influencing the entire food web. These changes are affecting the foraging and breeding ecology of most marine birds and mammals and are associated with an increase in abundance of several temperate fish, seabird and marine mammal species. Our review indicates that even though a few species are benefiting from a warming climate, most Arctic endemic species in Svalbard are experiencing negative consequences induced by the warming environment. Our review emphasizes the tight relationships between the marine and terrestrial ecosystems in this High Arctic archipelago. Detecting changes in trophic relationships within and between these ecosystems requires long‐term (multidecadal) demographic, population‐ and ecosystem‐based monitoring, the results of which are necessary to set appropriate conservation priorities in relation to climate warming.
Modelling climate change impacts on viticultural yield, phenology and stress conditions in Europe
Authors: Fraga Helder , García de Cortázar Atauri Iñaki , Malheiro Aureliano C. , Santos João A. 
Published: June 2016

AbstractViticulture is a key socio‐economic sector in Europe. Owing to the strong sensitivity of grapevines to atmospheric factors, climate change may represent an important challenge for this sector. This study analyses viticultural suitability, yield, phenology, and water and nitrogen stress indices in Europe, for present climates (1980–2005) and future (2041–2070) climate change scenarios (RCP4.5 and 8.5). The STICS crop model is coupled with climate, soil and terrain databases, also taking into account CO2 physiological effects, and simulations are validated against observational data sets. A clear agreement between simulated and observed phenology, leaf area index, yield and water and nitrogen stress indices, including the spatial differences throughout Europe, is shown. The projected changes highlight an extension of the climatic suitability for grapevines up to 55°N, which may represent the emergence of new winemaking regions. Despite strong regional heterogeneity, mean phenological timings (budburst, flowering, veraison and harvest) are projected to undergo significant advancements (e.g. budburst/harvest can be >1 month earlier), with implications also in the corresponding phenophase intervals. Enhanced dryness throughout Europe is also projected, with severe water stress over several regions in southern regions (e.g. southern Iberia and Italy), locally reducing yield and leaf area. Increased atmospheric CO2 partially offsets dryness effects, promoting yield and leaf area index increases in central/northern Europe. Future biomass changes may lead to modifications in nitrogen demands, with higher stress in northern/central Europe and weaker stress in southern Europe. These findings are critical decision support systems for stakeholders from the European winemaking sector.