bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward a spirituality mode of firm sustainability strategic planning processes
Authors: Barron Katelin , Chou Shih Yung 
Published: February 2017

PurposeThis paper aims to develop a spirituality mode of firm strategic planning processes that incorporate four basic firm spirituality elements, namely, transcendence, an inexhaustible source of will, a basic and supreme power and interconnectedness and oneness, used for promoting corporate and community sustainability.Design/methodology/approachA conceptual analysis was performed.FindingsDrawing upon prior research, this paper suggests that there are four major spiritual elements of the firm, namely, transcendence, an inexhaustible source of will, a basic and supreme power and interconnectedness and oneness. Additionally, this paper proposes that to promote long-term sustainability and survival of the firm and community, firms can place strong emphasis on firm transcendence when establishing the vision and mission statements. Moreover, firms may need to assess environmental conditions based upon an inexhaustible source of will. Furthermore, when formulating and selecting strategic alternatives, firms can utilize a basic and supreme power. Finally, firms may implement selected strategic alternatives and strategic controls with interconnectedness and oneness mentality.Originality/valueThis paper is one of the first studies that develop a spirituality mode of strategic planning processes focusing on both corporate and community sustainability.
Active synovitis in the presence of osteitis predicts residual synovitis in patients with rheumatoid arthritis with a clinical response to treatment
Authors: Fukae Jun , Tanimura Kazuhide , Isobe Masato , Kitano Akemi , Henmi Mihoko , Nakai Maria , Aoki Yuko , Sakamoto Fumihiko , Narita Akihiro , Ito Takeya , Mitsuzaki Akio , Matsuhashi Megumi , Shimizu Masato , Kamishima Tamotsu , Atsumi Tatsuya , Koike Takao 
Published: February 2017

AbstractAimTo clarify the relationship between active synovitis/osteitis and subsequent residual synovitis (R‐synovitis) in patients with rheumatoid arthritis (RA).MethodsThree hundred and twenty finger joints of 16 patients with active RA at baseline (Disease Activity Score with 28 joints – erythrocyte sedimentation rate > 3.2) who subsequently achieved clinical low disease activity or remission afterwards were analyzed. Synovial vascularity (SV) was assessed according to a semi‐quantitative ultrasound score (grades 0–3). Active synovitis was defined by SV positivity at baseline. R‐synovitis was defined by the presence of grade > 2 SV at the 24th week. Osteitis was detected by magnetic resonance imaging (MRI) at baseline as trabecular bone lesions with water content and indistinct margins.ResultsUltrasonography detected active synovitis in 116 joints at baseline. Forty‐seven joints had R‐synovitis at the 24th week. MRI detected osteitis in 12 joints at baseline. The presence of active synovitis with osteitis at baseline was significantly correlated with R‐synovitis at the 24th week.ConclusionsActive synovitis in the presence of osteitis predicted R‐synovitis regardless of whether there was a clinical improvement in RA.
A genome‐wide association analysis for carcass traits in a commercial Duroc pig population
Authors: Eusebi P. G. , González‐Prendes R. , Quintanilla R. , Tibau J. , Cardoso T. F. , Clop A. , Amills M. 
Published: February 2017

SummaryWe performed a genome‐wide association study to map the genetic determinants of carcass traits in 350 Duroc pigs typed with the Porcine SNP60 BeadChip. Association analyses were carried out using the gemma software. The proportion of phenotypic variance explained by the SNPs ranged between negligible to moderate (= 0.01–0.30) depending on the trait under consideration. At the genome‐wide level, we detected one significant association between backfat thickness between the 3rd and 4th ribs and six SNPs mapping to SSC12 (37–40 Mb). We also identified several chromosome‐wide significant associations for ham weight (SSC11: 51–53 Mb, three SNPs; 67–68 Mb, two SNPs), carcass weight (SSC11: 66–68 Mb, two SNPs), backfat thickness between the 3rd and 4th ribs (SSC12: 21 Mb, one SNP; 33–40 Mb, 17 SNPs; 51–58 Mb, two SNPs), backfat thickness in the last rib (SSC12: 37 Mb, one SNP; 40–41 Mb, nine SNPs) and lean meat content (SSC13: 34 Mb, three SNPs and SSC16: 45.1 Mb, one SNP; 62–63 Mb, 10 SNPs; 71–75 Mb, nine SNPs). The ham weight trait‐associated region on SSC11 contains two genes (UCHL3 and LMO7) related to muscle development. In addition, the ACACA gene, which encodes an enzyme for the catalysis of fatty acid synthesis, maps to the SSC12 (37–41 Mb) region harbouring trait‐associated regions for backfat thickness traits. Sequencing of these candidate genes may help to uncover the causal mutations responsible for the associations found in the present study.
Sokolow‐Lyon voltage is suitable for monitoring improvement in cardiac function and prognosis of patients with idiopathic dilated cardiomyopathy
Authors: Fukaya Kenji , Takeshita Kyosuke , Okumura Takahiro , Hiraiwa Hiroaki , Aoki Soichiro , Ichii Takeo , Sugiura Yuki , Kitagawa Katsuhide , Kondo Toru , Watanabe Naoki , Kano Naoaki , Furusawa Kenji , Sawamura Akinori , Morimoto Ryota , Bando Yasuko , Murohara Toyoaki 
Published: February 2017

BackgroundThe clinical significance of electrocardiogram in the assessment of patients with idiopathic dilated cardiomyopathy (IDCM) is currently unknown. The aim of this study was to determine the feasibility of recording serial changes in Sokolow–Lyon voltage (∆%QRS‐voltage) in one year to estimate left ventricular reverse remodeling (LVRR) and predict a prognosis of IDCM patients under tailored medical therapy.MethodsSixty‐eight consecutive patients with mild symptoms (52.1 ± 13 years old; 69% men; NYHA I/II/III/IV; 33/29/6/0) underwent electrocardiography and echocardiography at baseline and 12 month follow‐up (follow‐up period: 3.9 years).ResultsLVRR was observed in 30 patients (44.1%). The ∆%QRS‐voltage was significantly lower in the LVRR group (LVRR; −26.9%, non‐LVRR: −9.2%, p < .001). Univariate analysis showed that ∆%QRS‐voltage correlated with ∆%LV end‐diastolic diameter (r = .634, p < .001), and with ∆%LV ejection fraction and ∆%LV mass index (r = −.412, p < .001; r = .429, p < .001 respectively). Using receiver operating characteristic curve analysis for the estimation of LVRR, ∆%QRS of −14.7% showed optimal sensitivity (63.2%) and specificity (83.3%) (AUC = 0.775, p < .001). The composite endpoints of cardiac death (n = 0), hospitalization for advanced heart failure (n = 11) and fatal arrhythmia (n = 2) were observed in 13 patients during the follow‐up period. Kaplan–Meier analysis showed significantly higher event‐free rate in patients of the low ∆%QRS‐voltage group (<−14.7%) (83%) than those of the high group (66%, p = .022).ConclusionsThe present study showed that decrease in Sokolow–Lyon voltage is associated with improvement in cardiac function and favorable prognosis in IDCM patients on medical therapy, suggesting that this index is a feasible marker for response to treatment of IDCM.
Long‐term outcomes and risk factors of biliary stent dysfunction after endoscopic double stenting for malignant biliary and duodenal obstructions
Authors: Matsumoto Kazuyuki , Kato Hironari , Tsutsumi Koichiro , Mizukawa Sho , Yabe Syuntaro , Seki Hiroyuki , Akimoto Yutaka , Uchida Daisuke , Tomoda Takeshi , Yamamoto Naoki , Horiguchi Shigeru , Kuwaki Kenji , Okada Hiroyuki 
Published: February 2017

Background and AimFew reports describe the endoscopic double‐stenting procedure for malignant biliary and duodenal obstructions. We evaluated the clinical outcomes from double stenting, and analyzed the risk factors for biliary stent dysfunction following double stenting.MethodsEighty‐one patients who underwent endoscopic double stenting for malignant biliary and duodenal obstructions were retrospectively analyzed. We determined the stent dysfunction rate and the biliary stent dysfunction risk factors, and analyzed the endoscopic reintervention results.ResultsOverall survival time and survival time following double stenting were 365 (38–1673) days and 73 (20–954) days, respectively. After double stenting, the 3‐month and 6‐month duodenal stent dysfunction rates were 14% and 41%, respectively. Reintervention technical success rate was 100% (10/10), and mean gastric outlet obstruction scoring system scores improved from 0.7 to 2.4 points (P < 0.001). The 3‐month and 6‐month biliary stent dysfunction rates were 26% and 41%, respectively. The reintervention technical and clinical success rates were 95% (20/21) and 81% (17/21), respectively. Risk factors for biliary stent dysfunction following double stenting were events associated with duodenal stent dysfunction (odds ratio [OR], 11.1; 95% confidence interval [CI], 2.09–87.4; P = 0.0044) and the biliary stent end's location (OR, 6.93; 95% CI, 1.37–40.2; P = 0.0019).ConclusionsSome patients had stent dysfunction irrespective of the survival period after double stenting. Endoscopic reintervention was technically feasible and clinically effective even after double stenting. Duodenal stent dysfunction and biliary stent end's location were risk factors for biliary stent dysfunction.
Artificial selection on mating competitiveness ofAnastrepha ludensfor sterile insect technique application
Authors: Sánchez‐Rosario Mayren , Pérez‐Staples Diana , Toledo Jorge , Valle‐Mora Javier , Liedo Pablo 
Published: February 2017

AbstractThe sterile insect technique (SIT) has been applied successfully for the control of several fruit fly species of economic importance. In species with lek mating systems, as in theMexican fruit fly,Anastrepha ludens(Loew) (Diptera:Tephritidae) – where the variance in male mating success is high, males have to compete with other males, and where wild females are highly selective – the success ofSITdepends on the sexual competitiveness of mass‐reared sterile males. However, mass‐rearing conditions result in selection of sexual behavioral traits that differ from wild flies, reducing mating competitiveness of sterile flies andSITefficiency. Artificial selection in mass‐rearing colonies, based on male mating success, represents an alternative to improve the sexual performance of sterile males. Here, we evaluated the effect of selection ofA. ludensmass‐reared males based on their mating competitiveness. Two modes of selection were compared, one single selection event on parental flies, and continuous selection along four consecutive generations. For the offspring of each treatment in each generation, we evaluated male mating success, its association with post‐copulatory behavior through female remating inhibition, and life‐history traits that are key for mass‐rearing, such as immature survival and reproduction. Field cage mating tests revealed that wild males were more competitive than mass‐reared males (selected and unselected). Although no significant differences were found between mass‐reared selected and non‐selected males, in the fourth generation males from the selected colonies performed better than males from the non‐selected colonies and their mating competitiveness was similar to that of wild males. No consistent differences were observed in mating latency, copulation duration, or ability to inhibit female remating. Survival and fecundity decreased with increasing rearing generations, except in the colony with continuous selection where fecundity and fertility increased.
Validation of quantitative light‐induced fluorescence‐digital in the quantification of demarcated hypomineralized lesions of enamel
Authors: Gambetta‐Tessini Karla , Mariño Rodrigo , Ghanim Aghareed , Adams Geoffrey G. , Manton David J. 
Published: February 2017

AbstractAimThe aim of the present study was to determine the validity of quantitative light‐induced fluorescence‐digital (QLF‐D) in regard to the detection and quantification of developmental demarcated hypomineralized lesions of enamel in vitro when compared to micro‐computed tomography (CT) determination of lesion characteristics. A secondary aim was to develop a protocol for 3‐D analysis using micro‐CT.MethodsTwenty‐four hypomineralized defects were classified as cream/white (CW), yellow/brown (YB), and post‐eruptive breakdown. Teeth were scanned using micro‐CT. Grayscale and chromatic vertical sections were constructed. Mineral density and porosity percentage were calculated. Fluorescence loss and red fluorescence were determined from images. Linear mixed models were computed.ResultsMineral density and porosity mean values by lesion type were statistically different (P<.001). CW lesions had lower fluorescence loss than YB and broken lesions. Red fluorescence was emitted by the majority of the defects, and the means between lesion types were statistically different (P<.001). The mixed model indicated that mineral density was not correlated with fluorescence loss and lesion type.ConclusionThe present findings support QLF‐D as a method to detect hypomineralized lesions of different clinical presentation, with red fluorescence putatively related to the severity of the defects. The micro‐CT 3‐D approach is a reliable method to analyze structural changes in hypomineralized enamel.
Hair loss at injection sites of mesotherapy for alopecia
Authors: EL‐Komy Mohamed , Hassan Akmal , Tawdy Amira , Solimon Mohamed , Hady Mohamed Abdel 
Published: February 2017

SummaryBackgroundThe side effects of mesotherapy for treatment of various forms of alopecia are often underreported, while scientific data for its efficacy are severely lacking.ObjectiveTo demonstrate the late onset side effects of mesotherapy for alopecia.MethodsThree patients with androgenetic alopecia showed hair loss after previously uneventful mesotherapy sessions up to 1 year.ResultsClinical, dermoscopic, and histopathological findings suggested an inflammatory scaring process at sites of mesotherapy injections.ConclusionMesotherapy for androgenetic alopecia may paradoxically induce hair loss and scarring. Proper regulation and monitoring of the use of mesotherapy products for treating hair loss in women, needs to be addressed.
Biopharmaceutical Informatics: supporting biologic drug development via molecular modelling and informatics
Authors: Kumar Sandeep , Plotnikov Nikolay V , Rouse Jason C , Singh Satish K 
Published: February 2017

Abstract

Objectives
The purpose of this article is to introduce an emerging field called ‘Biopharmaceutical Informatics’. It describes how tools from Information technology and Molecular Biophysics can be adapted, developed and gainfully employed in discovery and development of biologic drugs.

Key Findings
The findings described here are based on literature surveys and the authors’ collective experiences in the field of biologic drug product development. A strategic framework to forecast early the hurdles faced during drug product development is weaved together and elucidated using chemical degradation as an example. Efficiency of translating biologic drug discoveries into drug products can be significantly improved by combining learnings from experimental biophysical and analytical data on the drug candidates with molecular properties computed from their sequences and structures via molecular modeling and simulations.

Summary
Biopharmaceutical Informatics seeks to promote applications of computational tools towards discovery and development of biologic drugs. When fully implemented, industry-wide, it will enable rapid materials-free developability assessments of biologic drug candidates at early stages as well as streamline drug product development activities such as commercial scale production, purification, formulation, analytical characterization, safety and in vivo performance.
A Device Histogram‐Based Simple Predictor of Mortality Risk in ICD and CRT‐D Patients: The Heart Rate Score
Authors: WILKOFF BRUCE L. , RICHARDS MARK , SHARMA ARJUN , WOLD NICHOLAS , JONES PAUL , PERSCHBACHER DAVID , OLSHANSKY BRIAN 
Published: February 2017

BackgroundWe hypothesized that survival in implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy defibrillator (CRT‐D) patients is predicted by baseline Heart Rate Score.MethodsHeart Rate Score is determined from the atrial paced and sensed histogram of a DDD ICD or CRT‐D, and defined as percent of beats in the histogram in the tallest 10 beats/min range bin. It was calculated at initial remote monitoring for patients enrolled in LATITUDE® without persistent atrial fibrillation, and with pulse generators implanted in 2006–2011. Univariate, multivariate, and Kaplan‐Meier analyses determined the impact of Heart Rate Score on survival.ResultsOf 57,893 ICDs and 67,929 CRT‐Ds followed for 2.4 ± 1.5 years, each 10% increase in Heart Rate Score was associated with decreased survival (CRT‐D hazard ratio [HR] 1.07 95%, confidence interval 1.06–1.07, P < 0.0001; ICD HR 1.05, 95% confidence interval 1.04–1.06, P < 0.0001). Multivariate analysis showed survival decreased with increasing age, atrial fibrillation, presence of a shock in first‐year follow‐up, and increasing programmed lower pacing rate in ICD and CRT‐D patients. Increased percent right ventricular pacing predicted mortality in ICD patients, while male gender and lower percent left ventricular pacing predicted mortality in CRT patients. Heart Rate Score predicted survival independent of those variables. Heart Rate Score correlates with heart rate variability (standard deviation of average R‐R intervals [SDANN]) when both are obtainable, but SDANN was only present in 6% of patients with Heart Rate Score >70%.ConclusionA simple device histogram measure, Heart Rate Score, predicts survival in ICD and CRT‐D patients independent of the available variables, and even when SDANN is unavailable.
The importance of person‐centred care and co‐creation of care for the well‐being and job satisfaction of professionals working with people with intellectual disabilities
Authors: van der Meer Leontine , Nieboer Anna Petra , Finkenflügel Harry , Cramm Jane Murray 
Published: February 2017

BackgroundPerson‐centred care and co‐creation of care (productive interactions between clients and professionals) are expected to lead to better outcomes for clients. Professionals play a prominent role in the care of people with intellectual disabilities at residential care facilities. Thus, person‐centred care and co‐creation of care may be argued to lead to better outcomes for professionals as well. This study aimed to identify relationships of person‐centred care and co‐creation of care with the well‐being and job satisfaction of professionals working with people with intellectual disabilities (PWID).MethodsA cross‐sectional survey was conducted in 2015 among professionals working at a disability care organisation in the Netherlands. All 1146 professionals involved in the care of people with intellectual disabilities who required 24‐hours care were invited to participate. The response rate was 41% (n = 466).ResultsMost respondents (87%) were female, and the mean age was 42.8 ± 11.5 years (22–65). The majority of respondents (70%) worked ≥22 hours per week and had worked for the organisation for ≥5 years (88%). Most of the respondents (76.8%) were direct care workers either in residential homes (59.3%) or in day activities (17.5%). After controlling for background variables, person‐centred care and co‐creation of care were associated positively with job satisfaction and well‐being of professionals.ConclusionsThe provision of person‐centred care and co‐creation of care may lead to better well‐being and job satisfaction among professionals working with PWID. This finding is important, as such professionals often experience significant levels of work stress and burnout.
A Changing Labour Market under the Intensification of Dualization. The Experience of a Southern European Society
Authors: Valadas Carla 
Published: February 2017

AbstractFifty years ago, a Portuguese sociologist, Adérito Sedas Nunes (1964), used the image of a ‘dual society under evolution’ to refer to Portugal. Since then, the image of Portugal as a country simultaneously old and new, (post) modern and traditional was used by several social scientists in various fields of research (migration, urban studies, social policy, education, culture). In spite of the remarkable process of modernization the country has experienced during this period of time, inequalities and dualisms continue to be deeply embedded in the economic and social system and were even intensified by recent austerity measures in the context of massive unemployment and economic distress.In the article, I examine two specific domains where signs of dualism(s) persist, the labour market and the system of welfare, and investigate how the interconnectedness between the two is generating new forms of social and economic inequalities. Reforms in the labour market have been under constant reform within the last decades, representing, for a large and increasing number of individuals, more precarious working conditions, low paid jobs, unstable lives with intermittent careers. At the same time, governmental policies have contributed to diminish the level of social protection for labour market participants in precarious employment as well as for people without jobs.This article aims at providing a contribution to the literature on dualization focusing on the link between changing forms of integration in the labour market and transformations in the social protection system, examining its specific configuration in one of the countries belonging to the Southern European welfare regime.
Mediating Policy Competition Through Campus Development in Dutch Limburg
Authors: Kooij Henk‐Jan 
Published: February 2017

AbstractOver the past decades, governments have switched from a managerial to an entrepreneurial style of governance in the strengthening of certain places at the expense of others. This coevolved with an increase in inter‐urban and inter‐regional competition for resources, also called ‘policy competition’. The issue for regional governments is how they balance their wish to strengthen their economic structure, without creating conflicts of unfair competition in the designation of ‘winners’ and ‘losers’. This paper addresses this balancing act in the Dutch Province of Limburg, where a multinational threatened to leave the region. The case is analysed with the help of actor‐network‐theory and follows the translations through which an innovative policy tool was constructed that allowed the Province to invest in real estate. Through the innovative ‘campus’ concept, the Province could comfort the vested interests of the multinational, while balancing out the interests of other economic cores in the region.
History Repeating! Spatial Dynamics in Dutch Start‐Up Rates (1996–2013)
Authors: Koster Sierdjan , Hans Lianne 
Published: February 2017

AbstractThe number of start‐ups has skyrocketed in the Netherlands in the past ten years. Has this growth been accompanied by a shift in the spatial patterns of start‐ups? This Windows on the Netherlands puts this question to the test and maps the dynamics in the spatial patterns of start‐ups for the period 1996–2013. This is done at the disaggregated spatial level of the municipality. Even though we observe a slight shift of entrepreneurship to the east of the country, the overall spatial patterns in start‐up intensity are highly stable: start‐up rates are highest in the most urbanised municipalities. As the small spatial scale of analysis potentially allows for much variability, the found stability in the spatial patterns lends additional empirical support to the idea that patterns in start‐up rates are highly persistent.