bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resource Seeking as Occupation: A Critical and Empirical Exploration
Authors: Aldrich Rebecca M. , Laliberte Rudman Debbie , Dickie Virginia A. 
Published: March 2017

Abstract
Occupational therapists and occupational scientists are committed to generating and using knowledge about occupation, but Western middle-class social norms regarding particular ways of doing have limited explorations of survival occupations. This article provides empirical evidence of the ways in which resource seeking constitutes an occupational response to situations of uncertain survival. Resource seeking includes a range of activities outside formal employment that aim to meet basic needs. On the basis of findings from 2 ethnographic studies, we critique the presumption of survival in guiding occupational therapy documents and the accompanying failure to recognize occupations that seem at odds with self-sufficiency. We argue that failing to name resource seeking in occupational therapy documents risks alignment with social, political, and economic trends that foster occupational injustices. If occupational therapists truly aim to meet society’s occupational needs, they must ensure that professional documents and discourses reflect the experiences of all people in society.
Embedding Questions During Online Lecture Capture to Promote Learning and Transfer of Knowledge
Authors: Griswold Lou Ann , Overson Catherine E. , Benassi Victor A. 
Published: March 2017

Abstract
We examined the effect of quizzing on students’ ability to apply lecture content to clinical examples on an in-class exam. Fifty-six occupational therapy students in a graduate-level course completed three online modules that included lectures, slide presentations, demonstrations, and video clips. Throughout each module, students were given “Learning Moments,” in which they were asked a question (Question condition); were asked to read a statement confirming the content presented (Study condition); or were not asked to do anything (Not Asked condition). The Question condition resulted in better exam performance than the combined Study and Not Asked conditions (p &lt; .01), whereas performance on Study and Not Asked questions did not differ (p = .67). Students performed better on material on which they had been previously quizzed (i.e., testing effect). Quizzing may be a good strategy to prepare students for clinical practice.
Characteristics of Students Receiving Occupational Therapy Services in Transition and Factors Related to Postsecondary Success
Authors: Eismann Maria M. , Weisshaar Rebecca , Capretta Cristina , Cleary Dennis S. , Kirby Anne V. , Persch Andrew C. 
Published: March 2017

Abstract
OBJECTIVE. This study had a twofold purpose: (1) identify the characteristics of people with disabilities who received occupational therapy services during their transition to adulthood and (2) determine factors associated with their successful postsecondary transition.
METHOD. This study was a secondary analysis of National Longitudinal Transition Study–2 data. Data analyses include descriptive statistics, binary logistic regression, and simple linear regression.
RESULTS. Autism, cerebral palsy, and intellectual disability were the most commonly reported disability classifications. Participation in postsecondary education was significantly associated with functional use of arms and hands. Postsecondary employment was significantly associated with verbal comprehension. Participation in community activities was significantly related to students’ health status, and participation in community service was significantly related to students’ functional use of arms and hands.
CONCLUSION. Providing transition services to students with disabilities remains an emerging area of practice. Occupational therapy practitioners may contribute to transition teams by intervening to improve functional abilities and health status.
Lean Construction Implementation in the Saudi Arabian Construction Industry
Authors: Sarhan Jamil Ghazi , Xia Bo , Fawzia Sabrina , Karim Azharul 
Published: March 2017

The Kingdom of Saudi Arabia (KSA) has witnessed a huge increase in construction during the last two decades. However, many projects experienced time delays, cost overruns and the generation of massive amounts of waste. To address these challenges, lean construction has been introduced into the Saudi construction industry; however, it is still in its infancy. This study therefore investigates the current state of lean construction implementation in the construction industry in the KSA. The objectives are to identify: the types of construction waste, level of use of tools that support the implementation of lean construction, stages of application of lean methods, and the benefits of lean construction. To achieve these objectives, a structured questionnaire survey of 282 construction professionals was carried out. After the analysis of the collected data using mean score and Anova test, the following conclusions were made. In the construction industry in the KSA, waiting is the most common type of waste, while Computer Aided Design (CAD) is the conventional tool supporting the implementation of lean construction. Furthermore, the data suggests that lean construction is most commonly used in the construction stage of projects while customer satisfaction is the main benefit derived from lean construction practices. This study concludes that the level of implementation of lean construction in the KSA construction industry is increasing. The results will help benchmark the current state of lean construction implementation, which will enable the construction industry to identify strategies to implement lean construction in Saudi Arabia in accordance with their needs and project goals, to achieve better productivity.
Correlation between Choroidal Thickness and Degree of Myopia Assessed with Enhanced Depth Imaging Optical Coherence Tomography
Authors: El-Shazly Amany A. , Farweez Yousra A. , ElSebaay Marwa E. , El-Zawahry Walid M.A. 
Published: March 2017

Purpose To assess the choroidal thickness in different degrees of myopia using enhanced depth imaging optical coherence tomography (EDI-OCT) compared with healthy subjects. Methods We included 240 patients with myopia and 60 emmetropes as controls. Participants underwent full ophthalmologic examination, axial length measurement, and EDI-OCT imaging of the choroid. Choroidal thickness (CT) was measured at 5 locations, including subfoveal (SFCT), 2 mm nasal, temporal, upper, and lower to fovea. Results Choroidal thickness was significantly lower in myopic eyes compared to controls. Regardless of the degree of myopia, nasal regions showed the lowest CT with decremental pattern with advance of myopia (low myopia 279.00 ± 24.50 µm, moderate myopia 269.58 ± 20.69 µm, high myopia 189.58 ± 25.95 µm, advanced myopia 96.75 ± 24.83 µm). Highest CT was variable according to the degree of myopia with decremental pattern with advance of myopia (low myopia in subfoveal region 354.40 ± 35.14 µm, moderate myopia in temporal region 337.87 ± 35.75 µm, high myopia in lower region 312.15 ± 38.90 µm, and advanced myopia in upper region 201.25 ± 18.27 µm). Axial length showed significant negative correlation with SFCT and CT in different studied regions. Conclusions Different degrees of myopia showed thinner choroidal thickness than that of normal control eyes with decremental thinning with progress of myopia. This might be secondary to the longer axial length, which was the determining factor in some locations such as subfoveal, nasal, and upper CT.
Deep Capillary Macular Perfusion Indices Obtained with OCT Angiography Correlate with Degree of Nonproliferative Diabetic Retinopathy
Authors: Sambhav Kumar , Abu-Amero Khaled K. , Chalam Kakarla V. 
Published: March 2017

Purpose To evaluate the integrity of macular and temporomacular vasculature in nonproliferative diabetic retinopathy (NPDR) with noninvasive optical coherence tomography angiography (OCTA) and correlate perfusion indices with degree of NPDR. Methods In this prospective observational cross-sectional study, 102 eyes with newly diagnosed NPDR (mild NPDR, 36; moderate NPDR, 21; severe NPDR, 13; NPDR with diabetic macular edema [DME], 32) underwent OCTA. Sixty eyes of normal subjects served as control. Degree of NPDR (based on Early Treatment Diabetic Retinopathy Study criteria) was confirmed with fluorescein angiography. Automated OCTA/split-spectrum amplitude decorrelation angiography software generated perfusion indices (vessel density and flow index) from images of the retina. The perfusion index of superficial and deep retinal plexuses was obtained in both perifoveal (central 1-3 mm) and parafoveal (3-6 mm) areas. Results Deep plexus parafoveal vessel density was 25.23% (±6.1) in mild NPDR, 20.16% (±6.16) in moderate NPDR, 11.16% (±4.16) in severe NPDR, and 17.91% (±4.42) in NPDR + DME compared to normal subjects (36.93% [±8.1]; (p<0.01). Spearman correlation coefficient (rs) between vessel density and level of NPDR severity in the parafoveal region showed inverse correlation for both superficial (rs -0.87; p = 0.083) and deep (rs -0.96; p = 0.017) plexus. Similarly, when vessel density of the perifoveal region was compared with level of NPDR severity, inverse correlation was noted in both superficial (rs -0.85; p = 0.08) and deep (rs -0.98; p = 0.011) plexus. Conclusions Optical coherence tomography angiography clearly delineated the retinal microcirculation and allowed quantification of vascular perfusion of each layer. As diabetic retinopathy progressed, a decrease in perfusion index is more pronounced in the deep retinal plexus and precedes changes in superficial plexus.
A Randomized Study of the Efficacy and Safety of 0.1% Cyclosporine a Cationic Emulsion in Treatment of Moderate to Severe Dry Eye
Authors: Baudouin Christophe , Figueiredo Francisco C. , Messmer Elisabeth M. , Ismail Dahlia , Amrane Mourad , Garrigue Jean-Sébastien , Bonini Stefano , Leonardi Andrea 
Published: March 2017

Purpose The SICCANOVE study aimed to compare the efficacy and safety of 0.1% cyclosporine A cationic emulsion (CsA CE) versus vehicle in patients with moderate to severe dry eye disease (DED). Methods In this multicenter, double-masked, parallel-group, controlled study, patients were randomized (1:1) to receive CsA CE (Ikervis®) or vehicle for 6 months. The co-primary efficacy endpoints at month 6 were mean change from baseline in corneal fluorescein staining (CFS; modified Oxford scale) and in global ocular discomfort (visual analogue scale [VAS]). Results The mean change in CFS from baseline to month 6 (CsA CE: n = 241; vehicle: n = 248) was significantly greater with CsA CE than with vehicle (-1.05 ± 0.98 and -0.82 ± 0.94, respectively; p = 0.009). Ocular discomfort improved similarly in both groups; however, the percentage of patients with ≥25% improvement in VAS was significantly higher with CsA CE (50.2%) than with vehicle (41.9%; p = 0.048). In a post hoc analysis of patients with severe ocular surface damage (CFS score 4) at baseline (CsA CE: n = 43; vehicle: n = 42), the percentage of patients with improvements of ≥2 grades in CFS score and ≥30% in Ocular Surface Disease Index score was significantly greater with CsA CE (p = 0.003). Treatment compliance and ocular tolerability were satisfactory and as expected for CsA use. Conclusion Cyclosporine A CE was well-tolerated and effectively improved signs and symptoms in patients with moderate to severe DED over 6 months, especially in patients with severe disease, who are at risk of irreversible corneal damage.
Timeline of Authorization and Reimbursement for Oncology Drugs in Italy in the Last 3 Years
Authors: Prada Mariangela , Ruggeri Matteo , Sansone Carmen , De Fazio Dalila , Tettamanti Alessia , Mantovani Matteo 
Published: March 2017

Introduction The main purpose of this analysis was to quantify the time elapsed between the validation date of European Medicines Agency (EMA) centralized procedure and the first purchase of a product by at least 1 Italian health care structure, evaluating different variables that affect the process, the number of products approved by the Committee for Medicinal Products for Human Use (CHMP) that are available on the Italian market (July 2016), and the impact of the Cnn class for oncology drugs in Italy. Methods A panel of oncology products has been defined, which considered drugs approved by the EMA between January 2013 and December 2015, and authorized for the treatment of oncology diseases, excluding generics. Data were obtained via the EMA website by the Agenzia Italiana del Farmaco (AIFA; the Italian Medicine Agency) meeting reports, by official administrative acts of marketing authorization, and the date of the first purchase (first day of the first handling month). Results The mean time of EMA evaluation for the considered panel of medicines was about 441 days (standard deviation (SD) 108; range 266-770); the average approval time for AIFA was about 248 days (SD 131; range 85-688). Interestingly, the mean AIFA evaluation time decreased significantly from 264 days for products submitted to AIFA assessment in 2013-2014 to 219 days for products evaluated in 2015-2016. Focusing on the regional access, both the timing and the number of drugs available for patients were widely different from region to region. Discussion A reduction in the approval time in the last 2 years has been observed in Italy. However, several variables influence the efficiency of the process and need to be addressed to make the access to drugs timely and efficient.
Chyluria: The State of the Art
Authors: Guttilla Andrea , Beltrami Paolo , Bettin Laura , Galantini Andrea , Dal Moro Fabrizio , Ficarra Vincenzo , Zattoni Filiberto 
Published: March 2017

Chyluria is the passage of chyle in the urine. The cause seems to be the rupture of retroperitoneal lymphatics into the pyelocaliceal system, giving urine a milky appearance. This communication is caused by the obstruction of lymphatic drainage proximal to intestinal lacteals, resulting in dilatation of distal lymphatics and the eventual rupture of lymphatic vessels into the urinary collecting system. This condition, if left untreated, leads to significant morbidity because of hematochyluria, recurrent renal colic, nutritional problems due to protein losses and immunosuppression resulting from lymphocyturia. In this review, we summarize the state of the art of this condition and the newest treatments available.
Estimation of pasture herbage intake by beef cattle based on n-alkanes as markers
Authors: Nowakowski Piotr , Czyz Katarzyna , Iwaszkiewicz Marta 
Published: March 2017

The aim of the study was to evaluate herbage dry matter intake in 16 beef cows which grazed continuously on permanent pastures within the “The Warta Estuary” National Park (Poland), using the minimally invasive method based on <em>n</em>-alkanes as markers (C<sub>29</sub>, C<sub>31</sub>, C<sub>33</sub>). Significant differences were observed in the nutritive value of herbage collected for analyses by cutting or nipping. The calculated content of energy and protein in the nipped herbage was higher: UFL by 58.1% and PDI by 50%, with a higher digestibility of nutrients. The values obtained for DM intake in pasture herbage by cows were closest to the standards when calculations were based on the C<sub>29</sub>/C<sub>32</sub> pair of <em>n</em>-alkanes. However, the best prediction of DM intake estimation from creeping bentgrass (<em>Agrostis stolonifera</em>) pasture, in agreement with the accepted energy and protein standards, was based on the proportions between alkanes C<sub>31</sub>/C<sub>32</sub>.
Development and Validation of Clinical Whole-Exome and Whole-Genome Sequencing for Detection of Germline Variants in Inherited Disease
Authors: Hegde Madhuri , Santani Avni , Mao Rong , Ferreira-Gonzalez Andrea , Weck Karen E. , Voelkerding Karl V. 
Published: March 2017

Context.—
With the decrease in the cost of sequencing, the clinical testing paradigm has shifted from single gene to gene panel and now whole-exome and whole-genome sequencing. Clinical laboratories are rapidly implementing next-generation sequencing–based whole-exome and whole-genome sequencing. Because a large number of targets are covered by whole-exome and whole-genome sequencing, it is critical that a laboratory perform appropriate validation studies, develop a quality assurance and quality control program, and participate in proficiency testing.

Objective.—
To provide recommendations for whole-exome and whole-genome sequencing assay design, validation, and implementation for the detection of germline variants associated in inherited disorders.

Data Sources.—
An example of trio sequencing, filtration and annotation of variants, and phenotypic consideration to arrive at clinical diagnosis is discussed.

Conclusions.—
It is critical that clinical laboratories planning to implement whole-exome and whole-genome sequencing design and validate the assay to specifications and ensure adequate performance prior to implementation. Test design specifications, including variant filtering and annotation, phenotypic consideration, guidance on consenting options, and reporting of incidental findings, are provided. These are important steps a laboratory must take to validate and implement whole-exome and whole-genome sequencing in a clinical setting for germline variants in inherited disorders.
Human impact on long‐term organic carbon export to rivers
Authors: Noacco Valentina , Wagener Thorsten , Worrall Fred , Burt Tim P. , Howden Nicholas J. K. 
Published: March 2017

AbstractAnthropogenic landscape alterations have increased global carbon transported by rivers to oceans since preindustrial times. Few suitable observational data sets exist to distinguish different drivers of carbon increase, given that alterations only reveal their impact on fluvial dissolved organic carbon (DOC) over long time periods. We use the world's longest record of DOC concentrations (130 years) to identify key drivers of DOC change in the Thames basin (UK). We show that 90% of the long‐term rise in fluvial DOC is explained by increased urbanization, which released to the river 671 kt C over the entire period. This source of carbon is linked to rising population, due to increased sewage effluent. Soil disturbance from land use change explained shorter‐term fluvial responses. The largest land use disturbance was during the Second World War, when almost half the grassland area in the catchment was converted into arable land, which released 45 kt C from soils to the river. Carbon that had built up in soils over decades was released to the river in only a few years. Our work suggests that widespread population growth may have a greater influence on fluvial DOC trends than previously thought.
Spatial and temporal estimates of population exposure to wildfire smoke during the Washington state 2012 wildfire season using blended model, satellite, and in situ data
Authors: Lassman William , Ford Bonne , Gan Ryan W. , Pfister Gabriele , Magzamen Sheryl , Fischer Emily V. , Pierce Jeffrey R. 
Published: March 2017

AbstractIn the western U.S., smoke from wild and prescribed fires can severely degrade air quality. Due to changes in climate and land management, wildfires have increased in frequency and severity, and this trend is expected to continue. Consequently, wildfires are expected to become an increasingly important source of air pollutants in the western U.S. Hence, there is a need to develop a quantitative understanding of wildfire‐smoke‐specific health effects. A necessary step in this process is to determine who was exposed to wildfire smoke, the concentration of the smoke during exposure, and the duration of the exposure. Three different tools have been used in past studies to assess exposure to wildfire smoke: in situ measurements, satellite‐based observations, and chemical‐transport model (CTM) simulations. Each of these exposure‐estimation tools has associated strengths and weakness. We investigate the utility of blending these tools together to produce estimates of PM2.5 exposure from wildfire smoke during the Washington 2012 fire season. For blending, we use a ridge‐regression model and a geographically weighted ridge‐regression model. We evaluate the performance of the three individual exposure‐estimate techniques and the two blended techniques by using leave‐one‐out cross validation. We find that predictions based on in situ monitors are more accurate for this particular fire season than the CTM simulations and satellite‐based observations because of the large number of monitors present; therefore, blending provides only marginal improvements above the in situ observations. However, we show that in hypothetical cases with fewer surface monitors, the two blending techniques can produce substantial improvement over any of the individual tools.
LaTiOxNy Thin Film Model Systems for Photocatalytic Water Splitting: Physicochemical Evolution of the Solid–Liquid Interface and the Role of the Crystallographic Orientation
Authors: Pichler Markus , Si Wenping , Haydous Fatima , Téllez Helena , Druce John , Fabbri Emiliana , Kazzi Mario El , Döbeli Max , Ninova Silviya , Aschauer Ulrich , Wokaun Alexander , Pergolesi Daniele , Lippert Thomas 
Published: March 2017

The size of the band gap and the energy position of the band edges make several oxynitride semiconductors promising candidates for efficient hydrogen and oxygen production under solar light illumination. Intense research efforts dedicated to oxynitride materials have unveiled the majority of their most important properties. However, two crucial aspects have received much less attention: One is the critical issue of compositional/structural surface modifications that occur during operation and how these affect photoelectrochemical performance. The second concerns the relation between electrochemical response and the crystallographic surface orientation of the oxynitride semiconductor. These are indeed topics of fundamental importance, since it is exactly at the surface where the visible‐light‐driven electrochemical reaction takes place.In contrast to conventional powder samples, thin films represent the best model system for these investigations. This study reviews current state‐of‐the‐art oxynitride thin film fabrication and characterization, before focusing on LaTiO2N, selected as a representative photocatalyst. An investigation of the initial physicochemical evolution of the surface is reported. Then, it is shown that after stabilization the absorbed photon‐to‐current conversion efficiency of epitaxial thin films can differ by about 50% for different crystallographic surface orientations, and be up to 5 times larger than for polycrystalline samples.
2‐Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide
Authors: Chandgude Ajay L. , Li Jingyao , Dömling Alexander 
Published: March 2017

Abstract2‐Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four‐component reaction (Ugi‐4CR) and Ugi‐tetrazole reaction. The cleavage of this isocyanide from 17 examples in both acidic and basic conditions is presented. Additionally, this isocyanide has various handling and synthetic advantages, as it is easy to prepare, odorless, stable, and easy to handle as a solid.