bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biomarker‐driven phenotyping in Parkinson's disease: A translational missing link in disease‐modifying clinical trials
Authors: Espay Alberto J. , Schwarzschild Michael A. , Tanner Caroline M. , Fernandez Hubert H. , Simon David K. , Leverenz James B. , Merola Aristide , Chen‐Plotkin Alice , Brundin Patrik , Kauffman Marcelo A. , Erro Roberto , Kieburtz Karl , Woo Daniel , Macklin Eric A. , Standaert David G. , Lang Anthony E. 
Published: February 2017

ABSTRACTPast clinical trials of putative neuroprotective therapies have targeted PD as a single pathogenic disease entity. From an Oslerian clinicopathological perspective, the wide complexity of PD converges into Lewy bodies and justifies a reductionist approach to PD: A single‐mechanism therapy can affect most of those sharing the classic pathological hallmark. From a systems‐biology perspective, PD is a group of disorders that, while related by sharing the feature of nigral dopamine‐neuron degeneration, exhibit unique genetic, biological, and molecular abnormalities, which probably respond differentially to a given therapeutic approach, particularly for strategies aimed at neuroprotection. Under this model, only biomarker‐defined, homogenous subtypes of PD are likely to respond optimally to therapies proven to affect the biological processes within each subtype. Therefore, we suggest that precision medicine applied to PD requires a reevaluation of the biomarker‐discovery effort. This effort is currently centered on correlating biological measures to clinical features of PD and on identifying factors that predict whether various prodromal states will convert into the classical movement disorder. We suggest, instead, that subtyping of PD requires the reverse view, where abnormal biological signals (i.e., biomarkers), rather than clinical definitions, are used to define disease phenotypes. Successful development of disease‐modifying strategies will depend on how relevant the specific biological processes addressed by an intervention are to the pathogenetic mechanisms in the subgroup of targeted patients. This precision‐medicine approach will likely yield smaller, but well‐defined, subsets of PD amenable to successful neuroprotection. © 2017 International Parkinson and Movement Disorder Society.
Extending the limits of the anterior tibial artery as the recipient vessel for around the knee and proximal lower extremity defect reconstruction using the free anterolateral thigh and gracilis flap
Authors: Tremp Mathias , Kappos Elisabeth A. , Oranges Carlo M. , di Summa Pietro G. , Schaefer Dirk J. , Zhang Yi Xin , Wettstein Reto , Kalbermatten Daniel F. 
Published: February 2017

PurposeThe aim is to describe a technique with orthograde dissection of the anterior tibial artery (ATA) used as the recipient vessel for the end‐to‐end (ETE) anastomosis in defect reconstruction around the knee and for proximal/middle third leg defects with free anterolateral thigh (ALT) and gracilis flaps.Patients and methodsBetween March 2009 and May 2014, 22 patients undergoing lower extremity reconstruction were evaluated. Of those, 4 patients were included. The locations of injury were 3 defects around the knee and 1 defect at the proximal and middle third of the lower leg (mean defect size 18 x 8.5 cm and a range of 17‐20 x 5‐10 cm). There were 2 cases after trauma and 2 cases with infection. Two free gracilis and 2 free ALT flaps were performed of equal size to the defects. The mean flap pedicle length was 11 cm (range of 7–16 cm) and the mean length of the mobilized recipient vessels was 10.5 cm (range of 6–14 cm).ResultsOne flap loss (ALT) occurred, requiring a salvage procedure with a latissimus dorsi flap, whereas wound dehiscence at the donor site and a hematoma below the ALT flap was observed in 2 cases, requiring small revision. After a mean follow‐up of 52 months (range of 38–87 months), there was stable soft tissue coverage in all patients.ConclusionBy orthograde dissection of the ATA, an adequate vessel length and size may be achieved, improving arc of rotation to successfully cover more distant defects.
Dietary fat quantity and quality modifies advanced glycation end products metabolism in patients with metabolic syndrome
Authors: Lopez‐Moreno Javier , Quintana‐Navarro Gracia M. , Camargo Antonio , Jimenez‐Lucena Rosa , Delgado‐Lista Javier , Marin Carmen , Tinahones Francisco J. , Striker Gary E. , Roche Helen M. , Perez‐Martinez Pablo , Lopez‐Miranda Jose , Yubero‐Serrano Elena M. 
Published: February 2017

ScopeAdvanced glycation end products (AGEs) increase in dysmetabolic conditions. Lifestyle, including diet, has shown be effective in preventing the development of metabolic syndrome (MetS). We investigated whether AGE metabolism is affected by diets with different fat quantity and quality in MetS patients.Methods and resultsA randomized, controlled trial assigned 75 MetS patients to one of four diets: high SFA (HSFA), high MUFA (HMUFA), and two low‐fat, high‐complex carbohydrate diets (LFHCC) supplemented with long‐chain n‐3 PUFA or placebo for 12‐weeks each. Dietary and serum AGE [methylglyoxal (MG: lysine‐MG‐H1) and N‐carboxymethyllysine] levels and gene expression related to AGE metabolism in peripheral blood mononuclear cells (AGER1, RAGE, GloxI, and Sirt1 mRNA) were determined. HMUFA diet reduced serum AGE (sAGE) and RAGE mRNA, increased AGER1 and GloxI mRNA levels compared to the other diets. LFHCC n‐3 diet reduced sAGE levels and increased AGER1 mRNA levels compared to LFHCC and HSFA diets. Multiple regression analyses showed that sMG and AGER1 mRNA appeared as significant predictors of oxidative stress/inflammation‐related parameters.ConclusionsLow AGE content in HMUFA diet reduces sAGEs and modulates the gene expression related to AGE metabolism in MetS patients, which may be used as a therapeutic approach to reduce the incidence of MetS and related chronic diseases.
Employee Satisfaction With Work‐life Balance Policies And Organizational Commitment: A Philippine Study
Authors: Kim Ji Sung , Ryu Sangyub 
Published: February 2017

SummaryThis study investigates the relationship between public employees' satisfaction with work‐life balance policies (WLBPs) and organizational commitment in the relatively unexplored Philippine context. Our findings show that (i) employees' overall satisfaction with WLBPs is positively related to organizational commitment, (ii) when specific WLBPs are examined, only satisfaction with health and wellness programs are positively associated with organizational commitment, and (iii) when accounting for employees' preferences for WLBPs, compensatory time‐off, childcare policy, health insurance benefits, and paid sick leave are positively related to organizational commitment. The findings indicate that understanding which WLBPs employees prefer is important before implementing WLBPs. The article discusses the theoretical and practical implications of this study in the developing country context. Copyright © 2017 John Wiley & Sons, Ltd.
Risk factors and surveillance for reduced bone mineral density in pediatric cancer survivors
Authors: Siegel David A. , Claridy Mechelle , Mertens Ann , George Elizabeth , Vangile Kristen , Simoneaux Stephen F. , Meacham Lillian R. , Wasilewski‐Masker Karen 
Published: February 2017

AbstractBackgroundPediatric cancer survivors are at increased risk of developing low bone mineral density (BMD) due to cancer treatment. This study assessed the yield of screening for low BMD in pediatric‐aged cancer survivors as per the Children's Oncology Group Long‐Term Follow‐Up (COG‐LTFU) Guidelines, which recommend screening survivors who received steroids, methotrexate, or hematopoietic cell transplant (HCT).MethodsThis is a retrospective cohort study of 475 pediatric blood cancer and noncentral nervous system solid tumor survivors screened for low BMD with dual‐energy X‐ray absorptiometry (DXA) as per the COG‐LTFU Guidelines from 2003 to 2010. Risk factors for low BMD (DXA Z‐score ≤–2) were evaluated by univariate and multivariate analysis.ResultsThe mean DXA Z‐score was –0.1 for both whole body and lumbar spine measurements. Among at‐risk survivors, 8.2% (39/475) had low BMD. Multivariate analysis of survivors with low BMD showed significant association with male gender (odds ratio [OR] 3.4, 95% confidence interval [CI], 1.3–9.0), exposure to total body irradiation (TBI), cranial, or craniospinal radiation (OR 5.2, 95% CI, 1.8–14.9), and gonadal dysfunction (OR 4.3, 95% CI, 1.4–13.0). Methotrexate exposure was not significantly associated with low BMD. Survivors receiving HCT had a reduced risk of low BMD (OR 0.2, 95% CI, 0.1–0.9).ConclusionThe highest risk factors for low BMD were male gender, exposure to TBI, cranial, or craniospinal radiation, and gonadal dysfunction. Survivors receiving methotrexate or HCT therapy have the lowest risk for low BMD among those screened. Future studies should investigate risk of low BMD for survivors receiving HCT without radiation exposure.
Origin Discrimination of Osmanthus fragrans var. thunbergii Flowers using GC–MS and UPLC‐PDA Combined with Multivariable Analysis Methods
Authors: Zhou Fei , Zhao Yajing , Peng Jiyu , Jiang Yirong , Li Maiquan , Jiang Yuan , Lu Baiyi 
Published: February 2017

AbstractIntroductionOsmanthus fragrans flowers are used as folk medicine and additives for teas, beverages and foods. The metabolites of O. fragrans flowers from different geographical origins were inconsistent in some extent. Chromatography and mass spectrometry combined with multivariable analysis methods provides an approach for discriminating the origin of O. fragrans flowers.ObjectiveTo discriminate the Osmanthus fragrans var. thunbergii flowers from different origins with the identified metabolites.MethodsGC–MS and UPLC‐PDA were conducted to analyse the metabolites in O. fragrans var. thunbergii flowers (in total 150 samples). Principal component analysis (PCA), soft independent modelling of class analogy analysis (SIMCA) and random forest (RF) analysis were applied to group the GC–MS and UPLC‐PDA data.ResultsGC–MS identified 32 compounds common to all samples while UPLC–PDA/QTOF‐MS identified 16 common compounds. PCA of the UPLC‐PDA data generated a better clustering than PCA of the GC–MS data. Ten metabolites (six from GC–MS and four from UPLC‐PDA) were selected as effective compounds for discrimination by PCA loadings. SIMCA and RF analysis were used to build classification models, and the RF model, based on the four effective compounds (caffeic acid derivative, acteoside, ligustroside and compound 15), yielded better results with the classification rate of 100% in the calibration set and 97.8% in the prediction set.ConclusionsGC–MS and UPLC‐PDA combined with multivariable analysis methods can discriminate the origin of Osmanthus fragrans var. thunbergii flowers. Copyright © 2017 John Wiley & Sons, Ltd.
Structural and thermochemical studies on CH3SCH2CHO, CH3CH2SCHO, CH3SC(═O)CH3, and radicals corresponding to loss of H atom
Authors: Song Guanghui , Bozzelli Joseph W. 
Published: February 2017

AbstractCH3SCH2CHO, CH3CH2SCHO, and CH3SC(═O)CH3 are intermediates during the partial oxidation of CH3SCH2CH3 in the atmosphere and in combustion processes. Thermochemical properties (ΔHfo, So and Cp(T)), structures, internal rotor potentials, and C─H bond dissociation energies of the parent molecules and their radicals formed after loss of a hydrogen atom are of value in understanding the oxidation processes of methyl ethyl sulfide. The lowest energy molecular structures were initially determined using the density functional B3LYP/6‐311G/(2d,d,p) level of theory. Standard enthalpies of formation (ΔHfo298) for the radicals and their parent molecules were calculated using the density functional B3LYP/6‐31G(d,p), B3LYP/6‐31 + G(2d,p), and the composite CBS‐QB3 ab initio methods using isodesmic reactions. Internal rotation potential energy diagrams and internal rotation barriers were investigated using B3LYP/6‐31 + G(d,p) level calculations. The contributions for So298 and Cp(T) were calculated using the rigid rotor harmonic oscillator approximation on the basis of the structures and vibrational frequencies obtained by the density functional calculations, with contributions from torsion frequencies replaced by internal rotor contributions from the method of Pitzer‐Gwinn. The recommended values for enthalpies of formation of the most stable conformers of CH3SCH2CHO, CH3CH2SCHO, and CH3SC(═O)CH3 are −34.6 ± 0.8, −42.4 ± 1.2, and ‐49.7 ± 0.8 kcal/mol, respectively. The structural and thermochemical data presented for CH3SCH2CHO, CH3CH2SCHO, and CH3SC(═O)CH3 and their radicals are of value in understanding the mechanism and kinetics of methyl ethyl sulfide oxidation under varied temperatures and pressures. Group additivity values are developed for estimating properties of structurally similar, larger sulfur‐containing compounds.
Who are happy survivors? Physical, psychosocial, and spiritual factors associated with happiness of breast cancer survivors during the transition from cancer patient to survivor
Authors: Kang Danbee , Kim Im‐Ryung , Choi Eun‐Kyung , Yoon Jung Hee , Lee Se‐Kyung , Lee Jeong Eon , Nam Seok Jin , Han Wonshik , Noh Dong‐Young , Cho Juhee 
Published: February 2017

AbstractObjectiveThis study aims to evaluate physical, psychosocial, and spiritual factors associated with happiness in breast cancer survivors during the reentry period.MethodsIt is a cross‐sectional study with 283 nonmetastatic breast cancer survivors who completed treatment within 1 year. We included survivors who completed questionnaires on happiness and health‐related quality of life (QoL) 2 years after cancer diagnosis. Happiness and QoL was measured using the Subjective Happiness Scale and EORTC QLQ‐C30, respectively. Multivariable logistic regression was used to find factors associated with happiness.ResultsThe mean age of the study participants was 48.5 ± 7.8 years. Among the 283 survivors, 14.5%, 43.8%, 32.5%, and 2.1% reported being “very happy,” “happy,” “neutral,” and “not happy at all,” respectively. Happy survivors reported a better general health status and QoL (67.6 vs 49.6; P < .01), and fewer symptoms compared to unhappy survivors. Happy survivors were more likely to feel certain about the future (27.2% vs 11.9%, P < .01), have a strong purpose in life (22.4% vs 9.3%, P < .01), and feel hopeful (36.4% vs 8.5%, P < .01) compared to unhappy survivors. In a multivariate model, having purpose (OR = 2.50, 95% CI 1.42‐4.40) and hope (OR = 4.07, 95% CI 2.23‐7.45) in life were found to be associated with happiness.ConclusionsDuring the reentry period, breast cancer survivors who are hopeful and have a clear purpose in life are more likely to be happy than those who are not. Setting proper life goals might be beneficial to help breast cancer survivors who experience persistent QoL issues.
Kinetic Parameters of PBX Based on Cis‐1,3,4,6‐tetranitroocta‐hydroimidazo‐[4,5‐d] imidazole Obtained by Isoconversional Methods using Different Thermal Analysis Techniques
Authors: Elbeih Ahmed , Abd‐Elghany Mohamed , Klapötke Thomas M. 
Published: February 2017

AbstractThe thermal decomposition kinetics of the interesting polycyclic nitramine cis‐1,3,4,6‐tetranitrooctahydroimidazo‐[4,5‐d]imidazole (BCHMX) and its polymer bonded explosive (PBX) based on polyurethane matrix, have been investigated using different thermal analysis techniques and methods. The used polyurethane matrix is based on hydroxyl‐terminated polybutadiene (HTPB) cured by hexamethylene diisocyanate (HMDI). Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used nonisothermally, whereas the vacuum stability test (VST) was used isothermally. Kinetic parameters were determined by using isoconversional (model‐free) methods. Furthermore, the Advanced Kinetics and Technology Solution (AKTS) software was used to determine the kinetic parameters of the studied samples in order to provide a comparison. It was found that the decomposition temperature of BCHMX/HTPB is lower than that of pure BCHMX. All the applied techniques as well as computational results showed that BCHMX/HTPB has a lower activation energy than pure BCHMX. The different methods used, Kissinger, Ozawa, Flynn, and Wall (OFW) and Kissinger‐Akahira‐Sunose (KAS) methods presented activation energies in the same range of the AKTS software results. Also the results proved that VST technique could be a useful tool to present results suitable for calculation of the kinetic parameters of explosives.
Anticancer Activity of a Complex of CuII with 2‐(2‐hydroxyphenylazo)‐indole‐3/‐acetic Acid on three different Cancer Cell Lines: A Novel Feature for Azo Complexes
Authors: Ganguly Durba , Jain Chetan Kumar , Santra Ramesh Chandra , Roychoudhury Susanta , Majumder Hemanta Kumar , Mondal Tapan Kumar , Das Saurabh 
Published: February 2017

AbstractToxicity of azo dyes and theirinteraction with biological systems has either been overlooked or not exploited properly. A CuII complex of 2‐(2‐hydroxyphenylazo)‐indole‐3/‐acetic acid (HPIA) was synthesized to see role of metal ions on azo toxicity. It was characterized with UV‐Vis, IR, EPR, mass spectrometry, elemental and thermogravimetric analysis. Evidence suggest formation of a bis‐azo complex with stability constant logβ=12.88. DFT calculations based on spectroscopic evidence suggest 1:2::CuII:HPIA complex. Enzyme assay on reductive cleavage of the azo bond shows complex forms less amines than HPIA. Binding of complex to DNA was similar to HPIA. As the complex restricts reduction of azo bond to toxic amines and has comparable binding with DNA it could be less cytotoxic. Cis and trans HPIA and the complex were treated to normal HEK293T cells; activity was comparable at low concentrations. When compounds were treated to human colon carcinomaHCT116 cells, ALL MOLT‐4 human leukemia cells and MCF‐7 breast cancer cells activity of the complex was better than cisor trans HPIA. The study revealed complex formation of HPIA with CuII targets carcinoma cellsmore than HPIA.
PEO‐Silsesquioxane Flexible Membranes: Organic‐Inorganic Solid Electrolytes with Controlled Homogeneity and Nanostructure
Authors: Mehdi Ahmad , Cerclier Carole V. , Le Bideau Jean , Guyomard Dominique , Dalmas Florent , Chenal Jean‐Marc , Chazeau Laurent , Fontaine Olivier , Vioux André 
Published: February 2017

AbstractHybrid organic‐inorganic membranes with controlled nanostructures involving PEO chains and silica‐like cross‐linkers with remarkable nanoscale homogeneity were achieved by one‐pot sol‐gel process from PEO chains equipped with one or two hydrolysable silicon end‐groups. Playing on the molar ratio of mono‐ over bis‐silylated PEO precursors (up to 80%) permitted modulating the mesh size to looser networks with higher segmental motion. Typically, the influence of the nanostructure of the membranes on their electrochemical and cell performances was tested on networks filled with LiTFSI salt (with and without solvent) by means of complex impedance spectroscopy and galvanostatic cycling measurements.
Acidic‐Amino‐Acid‐Conjugated Dinucleosides as Ribonuclease A Inhibitors: Rational Design and Effect of Backbone Chirality on Enzyme Inhibition
Authors: Datta Dhrubajyoti , Mondal Pampa , Dasgupta Swagata , Pathak Tanmaya 
Published: February 2017

AbstractMolecular docking studies identified a dinucleoside connected with d‐aspartic acid residue as a more suitable competitive inhibitor of ribonuclease A. The chirality carbon of the d‐aspartic acid residue imposes a curvature in the molecule which is expected to make it a better inhibitor than its l‐aspartic acid congener due to more efficient binding with the active site. Experimental data established that the rational design of a dinucleoside by incorporating the predefined chirality in the backbone of the dinucleoside resulted in a half‐fold decrease of the inhibition constant compared to that of the l‐aspartic acid modified analogue. The dinucleoside also showed better lipophilicity as well as lower toxicity and opens up a new strategy for designing new class of inhibitors for RNase A.
Human Placenta-Derived Mesenchymal Stromal-Like Cells Enhance Angiogenesis via T Cell-Dependent Reprogramming of Macrophage Differentiation
Authors: He Shuyang , Gleason Joseph , Fik-Rymarkiewicz Ewa , DiFiglia Andrea , Bharathan Mini , Morschauser Andrew , Djuretic Ivana , Xu Yan , Krakovsky Michael , Jankovic Vladimir , Buensuceso Charito , Edinger James , Herzberg Uri , Hofgartner Wolfgang , Hariri Robert 
Published: February 2017

Abstract
Peripheral arterial disease (PAD) is a leading cause of limb loss and mortality worldwide with limited treatment options. Mesenchymal stromal cell (MSC) therapy has demonstrated positive effects on angiogenesis in preclinical models and promising therapeutic efficacy signals in early stage clinical studies; however, the mechanisms underlying MSC-mediated angiogenesis remain largely undefined. Here, we investigated the mechanism of action of human placenta-derived MSC-like cells (PDA-002) in inducing angiogenesis using mice hind limb ischemia model. We showed that PDA-002 improved blood flow and promoted collateral vessel formation in the injured limb. Histological analysis demonstrated that PDA-002 increased M2-like macrophages in ischemic tissue. Analysis of the changes in functional T cell phenotype in the draining lymph nodes revealed that PDA-002 treatment was associated with the induction of cytokine and gene expression signatures of Th2 response. Angiogenic effect of PDA-002 was markedly reduced in Balb/c nude mice compared with wild type. This reduction in efficacy was reversed by T cell reconstitution, suggesting T cells are essential for PDA-002-mediated angiogenesis. Furthermore, effect of PDA-002 on macrophage differentiation was also T cell-dependent as a PDA-002-mediated M2-like macrophage skewing was only observed in wild type and T cell reconstituted nude mice, but not in nude mice. Finally, we showed that PDA-002-treated animals had enhanced angiogenic recovery in response to the second injury when PDA-002 no longer persisted in vivo. These results suggest that PDA-002 enhances angiogenesis through an immunomodulatory mechanism involving T cell-dependent reprogramming of macrophage differentiation toward M2-like phenotype.
Neurobiology of Eye Movement Desensitization and Reprocessing
Authors: Vojtova Hana , Hasto Jozef 
Published: February 2017

Abstract
Eye Movement Desensitization and Reprocessing represents a promising approach to treatment of posttraumatic disorders. The specific factors underlying its effectiveness rely particularly on bilateral stimulation, which seems to provoke a specific neurobiological response during traumatic recall particularly in individuals with PTSD. The empirical findings provide evidence for the effect of BLS on autonomic nervous system shifting the balance towards parasympathetic activation (reducing arousal) as well as the effect on subjectively perceived vividness and emotional burden of autobiographic memories (decrease). The most credible hypotheses derive the effects from neurobiological mechanisms employed in dual focus attention, orienting reflex and REM sleep. Further research is needed to explore the processes included in the EMDR therapy in more detail and clarify the role of bilateral stimulation.
On the Plausibility of Psychotic Hallucinations
Authors: Franceschi Paul 
Published: February 2017

Abstract
In this paper, we describe several factors that can contribute, from the patient’s viewpoint, to the plausibility of psychotic hallucinations. We sketch then a Plausibility of Hallucinations Scale, consisting of a 50-item questionnaire, which aims at evaluating the degree of plausibility of hallucinations. We also emphasize the utility of pointing out to the patient the several factors that contribute to the plausibility of his/her hallucinations, in the context of cognitive therapy for schizophrenia.