bluuebunny/crossref_metadata_2025_split huggingface dataset:
Newly established borderline resectable 1 (BR1) category is one of the favorable candidates for selecting the use of multidisciplinary combination therapy in patients with advanced hepatocellular carcinoma treated with systemic therapy
Authors: Kawamura Yusuke , Akuta Norio , Shindoh Junichi , Matsumura Masaru , Okubo Satoshi , Tominaga Licht , Yamamoto Shigeki , Eriksson Yasuka , Hosaka Tetsuya , Saitoh Satoshi , Sezaki Hitomi , Suzuki Fumitaka , Suzuki Yoshiyuki , Ikeda Kenji , Arase Yasuji , Hashimoto Masaji , Kozuka Takuyo , Kumada Hiromitsu 
Published: September 2024

AbstractBackgroundThe aim of this study was to evaluate the newly established oncological criteria of resectability of hepatocellular carcinoma (HCC) for selecting suitable candidates for systemic and combination therapy.MethodsThe data of 156 consecutive HCC patients with intrahepatic target nodules who had initially received systemic therapy (lenvatinib and atezolizumab plus bevacizumab) were reviewed. The patients were classified into three groups according to the novel oncological criteria for resectability (R, resectable; BR1, borderline resectable 1; and BR2, borderline resectable 2). The prognostic ability and clinical utility for selecting this population to receive combined use of multiple systemic sequential and locoregional therapy was then evaluated. Combined use of systemic sequential therapy with more than two agents and locoregional treatment was defined as multidisciplinary combination therapy (MCT), while systemic sequential therapy only and repeated locoregional treatment was defined as a single treatment procedure (STP).ResultsPatients classified as R and BR1 had significantly better overall survival (OS) compared with BR2 (R vs. BR2, p = 0.012; BR1 vs. BR2, p = 0.004). However, there was no significant difference between R and BR1 (p = 1.000), in spite of significantly worse oncological status in the BR1 patients. Following a R0 resection and MCT, the BR1 patients had significantly better OS compared with those receiving STP or no additional treatment (median OS, not reached vs. 25.2 months and 20.1 vs. 11.3 months, respectively; p = 0.034).ConclusionsIn patients with advanced HCC with intrahepatic target nodules the BR1 category is one of the favorable candidates for selecting those to be treated with MCT strategies.
White light emission in Bi3+/Te4+ co‐doped Cs2SnCl6 for adjustable daily lighting and visible light communication
Authors: Chang Jianglong , Xu Sai , Liu Anliang , Li You , Liu Bo , Chen Baojiu 
Published: September 2024

Abstractns2 ions‐doped lead‐free perovskites have garnered significant attention for their potential in diverse optoelectronic applications, owing to their broad emission characteristics arising from self‐trapped excitons (STEs). Herein, high‐performance white light‐emitting diodes (WLEDs) for intelligent lighting are developed by Bi3+/Te4+co‐doped Cs2SnCl6. Effective energy transfer between the dual STE emissions results in tunable broadband emissions covering the full‐color region. Adjustable WLEDs containing cold‐ and warm‐white lighting are fabricated. The WLEDs have excellent luminescent performances coupled with adjustable correlated color temperatures of 6417 and 3829 K. This versatility allows them to meet lighting demand for different scenarios, which is essential for future WLEDs to achieve healthy lighting. In addition, the excellent white light emission characteristics can also be applied in the visible light communication (VLC) system, achieving a −3 dB bandwidth of 13.3 MHz and opening eye diagrams in the data rate range of 10–60 Mbps. This work represents a significant advancement toward building intelligent health lighting applications and achieving high‐quality light sources for VLC based on lead‐free perovskites.
Crying wolf, alarm safety and management in paediatrics: A scoping review
Authors: Cole Roni , Roderick Geraldine , Cheema Osayed , Cunninghame Jacqueline , Ullman Amanda J. 
Published: September 2024

AbstractAimTo provide a contemporaneous evidentiary overview of neonatal and paediatric studies investigating alarm‐related patient safety and alarm system management. Furthermore, to describe how clinical alarm burden is captured and reported, to identify clinical devices that contribute to alarm burden, to explore alarm‐related and patient safety measures and terminologies and to review alarm management initiatives.DesignScoping review.Data SourcesA systematic search of PubMed, Embase, Cumulative Index to Nursing and Allied Health Literature, Scopus and EBSCOhost was conducted from 2013 to 2023 using predetermined search terms, index terms, medical subject headings and truncation.MethodsObservational and qualitative studies with neonatal and paediatric populations reporting monitoring and alarm practices; and interventional studies reporting the success of alarm safety interventions were included. The quality of the included studies was assessed using the mixed methods appraisal tool.ResultsThe search yielded 37 studies of acceptable quality. The majority explored alarm burden associated with physiological monitoring (n = 35; 95%). Alarm definitions were reported in 46% (n = 17) of studies, and commonly included what constituted actionable and non‐actionable alarms. While 32% (n = 12) of studies considered alarms in relation to clinical outcomes surrounding patient safety, clinician response to alarms was only reported in 19% (n = 7) of studies. Alarm and monitoring interventions were assessed in 51% (n = 19) of included studies, with categorization into six domains: changing alarm parameters, clinician education, communication and planning, technology, alarm ordering and standardization or guidelines.ConclusionThis review has demonstrated the enormity of alarms in clinical settings, heterogeneity of alarm definitions and outlined interventions associated with alarm burden and patient safety.Implication for the Profession/Patient CareStrategies to ensure appropriate alarm limits are set and clinicians are empowered through education to recognize and respond appropriately to alarms can maximize patient safety.Reporting MethodThis review adheres to the preferred reporting items for systematic reviews and meta‐analysis protocols extension for scoping reviews.Patient or Public ContributionNo patient or public contribution.
Influence of glucagon‐like peptide‐1 receptor agonists on hepatic events in type 2 diabetes: a systematic review and meta‐analysis
Authors: Passos Pedro Robson Costa , Filho Valbert Oliveira Costa , Noronha Mariana Macambira , Hyppolito Elodie Bomfim , Saldanha Erick Figueiredo , Motta Rodrigo Vieira 
Published: September 2024

AbstractBackground and AimType 2 diabetes mellitus (T2DM) is intrinsically linked to various etiologies of liver disease, with 69% of patients having concomitant metabolic dysfunction‐associated steatotic liver disease (MASLD). Studies suggest glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) can ameliorating liver disease. With this analysis, we address the gap in knowledge about the effectiveness of these agents in preventing different major adverse liver outcomes (MALOs).MethodsPubMed, Embase, and The Cochrane Central of Trials were searched for articles reporting MALOs in T2DM patients. Publication bias‐identifying methods, quality assessment and sensitivity analyses (subgroup analyses, leave‐one‐out meta‐analyses, and meta‐regression) were employed. Statistical analyses were performed in R using the “meta” and “metafor” packages.ResultsNine cohort studies from 535 identified articles encompassing 579 256 T2DM patients were included in the main analyses. GLP‐1RA use was associated with reduced risks of hepatocellular carcinoma (HR 0.74, 95% CI 0.56–0.96) and cirrhosis decompensation (HR 0.68, 95% CI 0.65–0.72). Within the latter, variceal bleeding and hepatic encephalopathy prevention were found to be significantly reduced. Egger's test, Begg's test, and funnel‐plot analysis yielded no publication bias. No significant differences were observed in preventing cirrhosis or hepatic failure. Meta‐regression analysis revealed a positive correlation between hepatocellular carcinoma incidence and both male sex and longer follow‐up duration.ConclusionsThis meta‐analysis improves our understanding of the hepatoprotective effects of GLP‐1RAs in T2DM patients and supports existing research, exhibiting superiority over other antidiabetic medications for hepatoprotection in this subgroup. Additional long‐term follow‐up studies are necessary to further validate these findings.
DJ‐1 regulates astrocyte activation through miR‐155/SHP‐1 signaling in cerebral ischemia/reperfusion injury
Authors: Xue Ying , Wang Yuan , Chen Tianyi , Peng Li , Wang Chenglong , Xue Guijun , Yu Shanshan 
Published: September 2024

AbstractReactive astrocyte activation in the context of cerebral ischemia/reperfusion (I/R) injury gives rise to two distinct subtypes: the neurotoxic A1 type and the neuroprotective A2 type. DJ‐1 (Parkinson disease protein 7, PARK7), originally identified as a Parkinson's disease‐associated protein, is a multifunctional anti‐oxidative stress protein with molecular chaperone and signaling functions. SHP‐1 (Src homology 2 domain‐containing phosphatase‐1) is a protein tyrosine phosphatase closely associated with cellular signal transduction. miR‐155 is a microRNA that participates in cellular functions by regulating gene expression. Recent studies have uncovered the relationship between DJ‐1 and astrocyte‐mediated neuroprotection, which may be related to its antioxidant properties and regulation of signaling molecules such as SHP‐1. Furthermore, miR‐155 may exert its effects by influencing SHP‐1, providing a potential perspective for understanding the molecular mechanisms of stroke. A middle cerebral artery occlusion/reperfusion (MCAO/R) model and an oxygen–glucose deprivation/reperfusion (OGD/R) model were established to simulate focal cerebral I/R injury in vivo and in vitro, respectively. The in vivo interaction between DJ‐1 and SHP‐1 has been experimentally validated through immunoprecipitation. Overexpression of DJ‐1 attenuates I/R injury and suppresses miR‐155 expression. In addition, inhibition of miR‐155 upregulates SHP‐1 expression and modulates astrocyte activation phenotype. These findings suggest that DJ‐1 mediates astrocyte activation via the miR‐155/SHP‐1 pathway, playing a pivotal role in the pathogenesis of cerebral ischemia–reperfusion injury. Our results provide a potential way for exploring the pathogenesis of ischemic stroke and present promising targets for pharmacological intervention.
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Oncological outcomes and risk factors for recurrence of mucinous borderline ovarian tumors: A 15‐year experience at a tertiary center
Authors: Poonyakanok Vitcha , Warnnissorn Malee , Chaopotong Pattama 
Published: September 2024

AbstractBackgroundThe most common subtype of borderline ovarian tumors in Asia is mucinous borderline ovarian tumors (mBOTs). Intraoperative distinction from mucinous carcinoma can be difficult. Despite the indolent behavior of mBOTs, recurrence or metastases may occur. The objectives of this study were to determine the oncological outcomes of mBOTs and the risk factors for their recurrence.ResultsThis retrospective study enrolled patients with mBOTs treated or referred to our institution between January 2005 and December 2019. Histological reviews of the recurrent cases (primary and recurrent or metastatic tumors) were performed. Patients with other tumor subtypes, pseudomyxoma peritonei, or no in‐house operation were excluded. Two hundred thirty‐two patients were diagnosed with mBOTs. The median follow‐up was 52 months. Six patients (2.58%) had tumor recurrence or metastasis. The risk factors for recurrence were a ruptured tumor, residual tumor after an operation, high serum CA19‐9 level, and stage of the disease. The recurrence rates of fertility‐sparing and radical surgery were not significantly different. Detailed surgical staging, intraepithelial carcinoma, and microinvasion were also not associated with disease recurrence.ConclusionsmBOTs have an excellent prognosis. Currently, fertility‐sparing surgery is the standard treatment, showing no significant difference in oncological outcomes compared to radical surgery. Patients with risk factors should be closely monitored.
Effects of hot desert weathering on highly siderophile elements in ordinary chondrites
Authors: Almas Kiran Shahood , Ash Richard D. , Walker Richard J. 
Published: September 2024

AbstractOver 20,000 meteorites have been recovered from hot deserts. The effects of hot desert weathering upon highly siderophile elements (HSE) have been little studied. We have investigated the effects of neutral to mildly acidic leaching of three L6‐type ordinary chondrites of different weathering grades on HSE concentrations and Re‐Os isotopic systematics. We have characterized the bulk sample HSE patterns of these meteorites and conducted leaching experiments with progressively longer leaching times to determine the possible effects of long‐term residence in a desert. The most weathered sample (NWA 14239) displayed greater HSE concentration homogeneity than the other samples and released lower quantities of HSEs during leaching. Water leaching was milder than acetic acid and did not significantly modify the Re‐Os isotopic systematics of the residue relative to the bulk sample of NWA 869. Short‐term leachates of the less weathered samples (Viñales and NWA 869) were characterized by low 187Os/188Os ratios, indicating the preferential dissolution of early solar system–formed phases such as non‐magnetic chondrules and matrix with low Re/Os that are no longer intact in the most weathered sample. Of the HSE, Pd is most resistant to both water and acetic acid leaching, with a maximum removal of ~5% Pd, while Re, Os, and Ir are most mobile with up to 40% removal.
Chromatic acclimation in cyanobacteria renders robust photosynthesis and fitness in dynamic light environment: Recent advances and future perspectives
Authors: Mondal Soumila , Pandey Deepa , Singh Shailendra P. 
Published: September 2024

AbstractCyanobacteria are photoautotrophic organisms that use light and water as a source of energy and electrons, respectively, to fix atmospheric carbon dioxide and release oxygen as a by‐product during photosynthesis. However, photosynthesis and fitness of organisms are challenged by seasonal and diurnal fluctuations in light environments. Also, the distribution of cyanobacteria in a water column is subject to changes in the light regime. The quality and quantity of light change significantly in low and bright light environments that either limit photochemistry or result in photoinhibition due to an excess amount of light reaching reaction centers. Therefore, cyanobacteria have to adjust their light‐harvesting machinery and cell morphology for the optimal harvesting of light. This adjustment of light‐harvesting involves remodeling of the light‐harvesting complex called phycobilisome or incorporation of chlorophyll molecules such as chlorophyll d and f into their light‐harvesting machinery. Thus, photoacclimation responses of cyanobacteria at the level of pigment composition and cell morphology maximize their photosynthetic ability and fitness under a dynamic light environment. Cyanobacteria exhibit different types of photoacclimation responses that are commonly known as chromatic acclimation (CA). In this work, we discuss different types of CA reported in cyanobacteria and present a molecular mechanism of well‐known type 3 CA where phycoerythrin and phycocyanin of phycobilisome changes according to light signals. We also include other aspects of type 3 CA that have been recently studied at a molecular level and highlight the importance of morphogenes, cytoskeleton, and carboxysome proteins. In summary, CA gives a unique competitive benefit to cyanobacteria by increasing their resource utilization ability and fitness.
Exploring sex differences in cardiac interoceptive accuracy using the phase adjustment task
Authors: Spooner Ria , Bird Jonathan M. , Irigoras Izagirre Nerea , Clemente Rhea , Fernandez Fueyo Elisa , Budworth Gemma , Cocirla Dorina , Todd Jennifer , Aspell Jane , Leganes Mateo , Watling Dawn , Plans David , Brewer Rebecca , Murphy Jennifer 
Published: September 2024

AbstractPrevious evidence suggests males and females differ with respect to interoception—the processing of internal bodily signals—with males typically outperforming females on tasks of interoceptive accuracy. However, interpretation of existing evidence in the cardiac domain is hindered by the limitations of existing tools. In this investigation, we pooled data from several samples to examine sex differences in cardiac interoceptive accuracy on the phase adjustment task, a new measure that overcomes several limitations of the existing tools. In a sample of 266 individuals, we observed that females outperformed males, indicative of better cardiac interoceptive accuracy, but had lower confidence than males. These results held after controlling for sex differences in demographic, physiological and engagement factors. Importantly, these results were specific to the measure of cardiac interoceptive accuracy. No sex differences were observed for individuals who completed the structurally identical screener task, although a similar pattern of results was observed in relation to confidence. These surprising data suggest the presence of a female advantage for cardiac interoceptive accuracy and potential differences in interoceptive awareness (metacognition). Possible reasons for mixed results in the literature, as well as implications for theory and future research, are discussed.
‘A child who implores your clemency from his mother's womb’: emotion, inclusion and the unborn Condé child (1656)
Authors: Coons Jim 
Published: September 2024

AbstractIn the Fronde's aftermath, the treason and flight of the ‘Grand’ Prince of Condé Louis II de Bourbon raised pointed questions about belonging and community in Louis XIV's France, and news of his wife's 1656 pregnancy while in exile in Flanders further complicated those issues. The ambiguities surrounding the child's subjecthood, nobility and royalty were instantly apparent. Was it possible to preserve the status of a child of cadet royalty, conceived outside France by a father found guilty of lèse‐majesté and banished from the kingdom, presently leading Spanish armies? If it were a son, could the putative prince of royal blood claim a place in the line of succession? In the months of uncertainty before the child's birth, the Condé faction schemed to address vexing questions of inheritance, succession and fundamental terms of belonging. The issues they raised and the pathos‐laden tactics they pursued reveal key features of France's cultural, legal and affective landscape in the tumultuous years between the Fronde and the Sun King's ‘personal reign’, when modern notions of citizenship and nationality had just begun to take shape.
Kenelm Digby's logic of common and natural notions
Authors: Lærke Mogens 
Published: September 2024

AbstractIn this article, I take a fresh look at the logic of common and natural notions contained in the Two Treatises published in 1644 by Kenelm Digby (1603–1665). Digby's doctrine of common notions was an attempt to retrofit Aristotelianism in order to bring it out of the shadows of scholasticism and into the age of the new experimental and collaborative natural philosophy. To achieve that, he argued that natural philosophy began in the world of experience expressed in common language and was structured according to the basic principles he calls common notions. Taking my point of departure in his correspondence with Hobbes and Mersenne, I explore the Epicurean roots of this theory.
Voter attitudes and politicians with health conditions and disabilities
Authors: Magni Gabriele , Reynolds Andrew 
Published: September 2024

AbstractBackgroundMillions of Americans live with chronic health conditions and disabilities. While disability and disabling conditions are common in the United States, the number of politicians and candidates with disclosed disabilities or chronic health conditions remains extremely low.ObjectivesThis study examines what drives the lack of descriptive representation of individuals with disabilities or chronic health conditions. In particular, it examines whether disability bias, or more specifically ableism, drives voter bias against politicians with health challenges and disabilities.MethodsThe analysis relies on two original surveys with samples of American respondents that match Census quotas on key indicators. The first survey was administered to more than 1800 U.S. respondents in 2018. The second survey was administered to 6345 U.S. respondents in 2020. The approach combines observational and experimental data, as well as quantitative and qualitative analysis.ResultsThe findings reveal that voters are significantly less likely to support candidates with disclosed disabilities or health conditions. Mental illness and HIV face the strongest discrimination, while physical challenges due to birth conditions like wheelchair usage and dwarfism are the least penalized. A combination of prejudice, negative character assessment, and electability concerns drive voter bias.ConclusionUnderstanding the barriers to the election of politicians with disabilities and chronic health conditions is crucial to improve the representation of marginalized communities, as descriptive representation improves public policy outcomes for marginalized communities.
Geometry of Selberg's bisectors in the symmetric space SL(n,R)/SO(n,R)$SL(n,\mathbb {R})/SO(n,\mathbb {R})$
Authors: Du Yukun 
Published: September 2024

AbstractI study several problems about the symmetric space associated with the Lie group . These problems are connected to an algorithm based on Poincaré's Fundamental Polyhedron Theorem, designed to determine generalized geometric finiteness properties for subgroups of . The algorithm is analogous to the original one in hyperbolic spaces, while the Riemannian distance is replaced by an ‐invariant premetric. The main results of this paper are twofold. In the first part, I focus on questions that occurred in generalizing Poincaré's Algorithm to my symmetric space. I describe and implement an algorithm that computes the face‐poset structure of finitely sided polyhedra, and construct an angle‐like function between hyperplanes. In the second part, I study further questions related to hyperplanes and Dirichlet–Selberg domains in my symmetric space. I establish several criteria for the disjointness of hyperplanes and classify particular Abelian subgroups of based on whether their Dirichlet–Selberg domains are finitely sided or not.