bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimising Hybrid Asphalt Mixtures and Enhancing Prediction Models using Response Surface Methodology
Authors: Sani Wan Noor Hin Mior , Jaya Ramadhansyah Putra , Masri Khairil Azman , Al-Saffar Zaid Hazim , Hasan Mohd Rosli Mohd 
Published: September 2024

Abstract

Although waste materials in asphalt mixtures are promising in improving pavement performance, they have attracted considerable attention owing to ecological issues and the imperative for sustainable infrastructure. Thus, this article assessed the Marshall stability efficiency of hybrid asphalt mixtures containing palm oil fuel ash (POFA), garnet waste, and sawdust. Approximately 0%, 3%, 6%, and 9% of hybrid materials by asphalt weight were employed to assess the conventional features of hybrid asphalt mixtures. A central composite design (CCD) within the response surface methodology (RSM) framework was also utilised to examine the impact of several hybrid materials on the mechanical features of hybrid asphalt mixtures. This process involved considering three input response variables (POFA, garnet waste, and sawdust contents), along with four Marshall stability parameters [stability, flow, bulk density, and void in total mix (VTM)]. Consequently, a substantial correlation was yielded between the hybrid asphalt mixture and hot mix asphalt features. The hybrid contents presented a notable effect on the performance of the hybrid asphalt mixture. Among the samples, the 6% hybrid asphalt mixture demonstrated superior stability, with a Marshall stability value of 22.33 kN. Substantial correlations in the quadratic model were also observed between hybrid asphalt content and the mechanical performance of the hybrid asphalt mixture. The optimal percentages for hybrid materials were then determined using numerical optimisation and the resulting quadratic model. These values were 6.5%, 7.3%, and 6.5% for POFA, garnet waste, and sawdust. Given that all responses yielded a percentage error below 5%, this model revealed strong agreement and effectiveness. Compared to the commercial asphalt modification in terms of Marshall stability, this study confirmed the excellent precision of the prediction model while demonstrating that the optimised hybrid content formulations were better at similar amounts.
Facile Sol-Gel Synthesis, Structural Properties, and Characterization of Copper Titanate-Based Double Perovskites Modified with Lanthanides.
Authors: Duran Sergio Eduardo Negrete , Leal Edgar Giovanny Villabona , Ojeda-Galván Hiram Joazet , Alanís-Pérez Javier , Quintana-Ruiz Mildred , Rodriguez-Vazquez Angel Gabriel , Navarro-Contreras Hugo Ricardo 
Published: September 2024

Abstract

In this work, a facile methodology was developed through a Sol-Gel process assisted by citric acid for the synthesis of mixed oxides Ln2/3Cu3Ti4O12 (Ln = La, Pr, Nd, Gd, Er, Tm, and Yb), and Ce1/2Cu3Ti4O12. The XRD diffractograms refined by the Rietveld method allowed the identification of the phases present in the samples. Morphological determination by HRTEM showed the presence of crystallographic planes related to an adopted A type double perovskite structure, while STEM provided an elemental mapping of the synthetized nanocrystals. Through FTIR-ATR spectroscopy, the impact of calcination temperature on the structures was identified, pointing out changes in the vibrational modes corresponding to citrate ions and organic compounds, and showing the formation of modes related to metal-oxygen bonds. This study allowed us to conclude that the appropriate calcination temperature is 1070°C, producing predominantly 90% of the double perovskite structure in most of the sequence of lanthanides studied, and to propose the sol-gel methodology as a scalable and commercially convenient route to produce type A cation-ordered double perovskites Ln2/3Cu3Ti4O12. Through Raman spectroscopy, the characteristic vibrational modes of the Ln2/3Cu3Ti4O12 double perovskite structure were studied. DFT calculations were performed for the Ce1/2Cu3Ti4O12 compound to compare theory with experimental results. The optical characterization allowed the determination of the bandgap of the samples.
Assessing the Limitations of Relief-Based Algorithms in Detecting Higher-Order Interactions
Authors: Freda Philip J. , Ye Suyu , Zhang Robert , Moore Jason H. , Urbanowicz Ryan J. 
Published: September 2024

Abstract

Background: The investigation of epistasis becomes increasingly complex as more loci are considered due to the exponential expansion of possible interactions. Consequently, selecting key features that influence epistatic interactions is crucial for effective downstream analyses. Recognizing this challenge, this study investigates the efficiency of Relief-Based Algorithms (RBAs) in detecting higherorder epistatic interactions, which may be critical for understanding the genetic architecture of complex traits. RBAs are uniquely non-exhaustive, eliminating the need to construct features for every possible interaction and thus improving computational tractability. Motivated by previous research indicating that some RBAs rank predictive features involved in higher-order epistasis as highly negative, we explore the utility of absolute value ranking of RBA feature weights as an alternative method to capture complex interactions. We evaluate ReliefF, MultiSURF, and MultiSURFstar on simulated genetic datasets that model various patterns of genotype-phenotype associations, including 2-way to 5-way genetic interactions, and compare their performance to two control methods: a random shuffle and mutual information.
Results: Our findings indicate that while RBAs effectively identify lower-order (2 to 3-way) interactions, their capability to detect higher-order interactions is significantly limited, primarily by large feature count but also by signal noise. Specifically, we observe that RBAs are successful in detecting fully penetrant 4-way XOR interactions using an absolute value ranking approach, but this is restricted to datasets with a minimal number of total features.
Conclusions: These results highlight the inherent limitations of current RBAs and underscore the need for enhanced detection capabilities for the investigation of epistasis, particularly in datasets with large feature counts and complex higherorder interactions.
Unveiling anthropogenic disturbance effects on tropical tree communities: clade-based insights across elevations
Authors: Kamimura Vitor A. , Pinheiro Fábio , Neves Danilo Rafael Mesquita , Marcusso Gabriel Mendes , Sabino Gabriel Pavan , Assis Marco Antonio , Joly Carlos Alfredo , Loiola Priscilla P. 
Published: September 2024

Abstract

Community assemblies in tropical forests are influenced by both environmental filtering and anthropogenic disturbance processes, posing significant challenges in ecological research. We assessed the impact of selective logging on Atlantic tree communities at two elevational belts. Our study aimed to disentangle these complex effects, acknowledging that results can vary based on the clades used in the analyses. We performed analyses considering both species level and phylogenetic approaches, including or excluding tree ferns. Species and phylogenetic compositions changed at different elevations, depending on the clades used in analyses. The impact of selective logging was more pronounced in tree communities at lower elevations, indicating greater susceptibility to anthropogenic disturbances in these ranges. Additionally, tree species clades varied in their responses to environmental and anthropogenic filters, highlighting the importance of clade-specific characteristics in ecological studies. In general, we underscore the necessity for clade-specific analyses to enhance our understanding of community assembly processes and improve conservation strategies. By recognizing the differential responses of tree species clades, conservation efforts can be better tailored to address the unique challenges faced by different species and clades. This approach can contribute to more effective and sustainable management of tropical forest ecosystems in the face of ongoing environmental and anthropogenic changes.
Synthesis of Dual-responsive CMC-based Nanogels for Drug Delivery Applications
Authors: Cai Yuanpeng , Li Danyang , Peng Shaohua , Liu Hui 
Published: September 2024

Abstract

Nanogels offered a large surface area for biological conjugation due to their nanoscale size, enabling prolonged circulation in the bloodstream and targeted delivery to specific tissues. CMC/POM nanogels composed of 2-(2-(2-methoxyethoxy) ethoxy) ethyl methacrylate (MEO3MA), methacrylic acid (MAA) and natural biopolymer carboxymethyl cellulose (CMC), were synthesized via free radical polymerization. The chemical structures of CMC/POM nanogels were characterized using several techniques and the response behaviors under temperature and pH variations were reflected by changes in turbidity and particle size. The results demonstrated that CMC/POM nanogels exhibited significant changes in particle size and turbidity around 38°C and under different pH conditions. Additionally, the unique microstructure of CMC/POM nanogels made them promising for drug delivery through injection therapy. Choosing doxorubicin (DOX) as a model drug, the nanogels could achieve maximum drug loading content of 31.47% and drug loading efficiency of 62.93%. In vitro controlled drug releasing, the efficiency was up to 92.20% within 24 h at T = 45 ℃ & pH = 3.0. The cytotoxicity assays confirmed that CMC/POM nanogels possessed superior biocompatibility and drug-loaded CMC/POM nanogels effectively inhibited the activity of cancer cells. CMC/POM nanogels displayed remarkable potential as intelligent drug delivery systems and were expected to play an essential role in the field of anticancer therapies.
DNA barcode development based on chloroplast and ITS genes for species identification of endangered and threatened species of Western Ghats, India
Authors: Fatima Tanzeem , MN Srividya , MN Raj Kishore 
Published: September 2024

Abstract

Accurate identification is crucial for conserving species, especially in regions such as the Western Ghats, where trade poses a significant threat to endangered and threatened forest species. Traditional morphology-based identification can be challenging and time-consuming, leading to inaccuracies, especially with similar-looking species or dried specimens. Therefore, DNA barcoding offers a potent solution for precise species identification to address illicit trade and address impactful conservation measures. DNA barcoding is a taxonomic technique that uses standardized short DNA sequences to differentiate and classify species. This approach is especially valuable when morphological characteristics alone are insufficient for accurate species identification. In this study, we focused on the development of a DNA barcoding system for the efficient and accurate identification of threatened and endangered important forest species of Western Ghats Karnataka. To develop the DNA barcoding system, a multilocus approach utilizing sixteen standard DNA barcoding markers was used. A total of 47 threatened and endangered forest species from the Western Ghats were selected for this study. Using a larger number of markers to develop DNA barcodes led to the most precise species identification rates. Moreover, the wide availability of DNA barcode databases allows for quick and accurate species identification. In our study, we observed the highest amplification rates for rbcL1 (40 species), psbtrnH2 (36 species), and PsbA-trnH1 (33 species). DNA amplification varied from 11.76–94.11%. Notably, the highest DNA amplification rates were detected for A. wightii (94.11%) and A. hondala (92.34%), both of which belong to the Arecaceae and Passifloraceae families, respectively. Sequencing success rates ranged from 37.5–100%. This study will aid in the development of a database of available threatened forest species in western Ghats Karnataka and other regions.
The association between dietary acid load index with tumor stage and size, histological grade, Ki-67 marker, and the odds of breast cancer: A case-control study based on hospital evidence
Authors: Khodabakhshi Adele , Nasab Seyed Ali Razavi , Rafeeinia Arash , Hesami Saba , Bazyar Hadi , Aghamohammadi Vahideh 
Published: September 2024

Abstract

Introduction:
Several observational and ecological studies have found a positive association between dietary acid load (DAL) and increased risk of chronic diseases. There is limited evidence suggesting that an acidic environment may promote the growth of certain cancer cells and tumors. Therefore, this study aims to determine the association between the DAL and Pathobiological markers of BC and the risk of BC in Iranian women.
Methods and Materials:
In this hospital-based case-control study, 155 female BC patients confirmed by histopathology by a physician (cases) and 155 controls apparently healthy women (controls) were selected using convenience sampling. The DAL was measured based on a 168-item Food Frequency Questionnaire (FFQ). The odds of BC (95% CI) according to potential renal acid load (PRAL), net endogenous acid production (NEAP), and net acid excretion (NAE) quartiles compared to the reference (OR = 1) were measured using logistic regression, with adjustment of confounding.
Results
Using linear regression, no significant association was observed between the PRAL, NEAP, and NAE with pathobiological markers of breast cancer such as tumor size and Ki-67 marker (p > 0.05). Using multivariate logistic regression models, the Odds ratios (95%CI) of BC according to the quartile of the PRAL, NEAP, and NAE showed that All indices did not predict the risk of BC before and after adjustment (p > 0.05).
Conclusions
According to findings, DAL did not predict the risk of breast cancer. High-quality prospective studies are necessary to further specify the relationship between DAL and the risk of BC among the Iranian population.
Extremely rare frontal, temporal, and parietal giant cerebral hydatid cyst causing none communicating hydrocephalus a case report
Authors: Daniel Tigabu , woldegiorgis Tsegaye 
Published: September 2024

Abstract

Background: Hydatid disease is an animal illness that has been accidentally transmitted to humans. Humans become infected after consuming contaminated water or food, or via direct contact with canine feces. It is unusual to discover intracranial echynococosis. The therapy for an intracranial hydatid cyst is to perform a craniotomy and deliver the cyst intact, with concurrent pre and post-operative albendazole medication.
Case report: An eight-year-old child of Sidama ethnicity presented with a change in mentation and one week of projectile vomiting. She has left-extremity weakness, seizures, and a history of dog interaction. She was diagnosed with intracranial cerebral hydatid multiple cysts on the left cerebrum, which causes none communicating hydrocephalus. She was given oral albendazole, and an emergency base left craniotomy was performed, removing several cysts, daughter cysts, and some adhesions as intact cysts without rupture. Except for the power, all circumstances have improved dramatically. She was discharged with oral phenytoin, albendazole, and an appointment.
Conclusion: Intracranial hydatid cysts, notably frontal, temporal, and parietal, were highly unusual to occur. The mainstay of treatment is surgically removing a whole intact cyst and administering albendazole both before and after surgery.
Surgical exposure of turner’s tooth and CBCT representation of inverted tooth: A case report
Authors: CHOUGAONKAR AKSHADA , MASIH UPDESH , SONI NIDHI , AYAZ BILAL 
Published: September 2024

Enamel defects related to it’s thickness and quality are called hypoplasia, and they arise from disturbances in the enamel matrix development process. The possible developmental disruptions, which can range from mild changes in enamel mineralization to severe sequestration of the tooth germ, dilations of the crown or root, crown or root duplication, and complete or partial arrest of root formation, are explained by the topographic relationship between the primary tooth and the developing permanent tooth germ. Enamel in Turner's hypoplastic kinds might be shiny, rough, or pitted . It is extremely uncommon for permanent central incisor impaction and inversion to result from trauma, odontomas, and neighboring supernumerary teeth. Root development is restricted when incisors are displaced or impacted in the opposite direction. Dental radiographs and CBCT are used to assess the presence or absence of enamel thickening and inversion. This information is used not only for diagnosis but also to build the best possible treatment plan. Hence a case is presented of Turner’s hypoplasia and maxillary lateral incisor inversion in a 9 yr old female.

MESH- Turner’s Hypoplasia, Tooth inversion, CBCT, RVG
Incidence of Peri-implantitis and oral health related quality of life in patients rehabilitated with implants: A retrospective Study
Authors: Dr Muskan Agarwal  
Published: September 2024

Background: Peri-implantitits, periodontal disease and bone loss are main complications of dental implant treatment that can impact the quality of life .
Aim: This study aimed to determine incidence of Peri-implantitis and oral health related quality of life in patients rehabilitated with Implants by means of a shortened 14-item questionnaire of Oral Health Impact Profile Index (OHIP-14).
Materials and Methods: Sixty number of patients was included in this study who were diagnosed with peri implantitis. The participants were assessed on the basis of response received in Oral Health Impact Profile Index(OHIP-14) questionnaire. OHIP-14 is a Likert-type questionnaire that uses a 5- point rating scale (0 = never, 1 = rarely, 2 = sometimes, 3 = frequently and 4 = very often).
Results: A statistically significant correlation was noted between the Functional limitation domain with the psychological limitation and social limitation (p<0.0001).
Conclusions: Within the limitations of this study, it was observed that quality of life has been compromised due to peri implantitis. Results also indicated that patients should take action to improve their oral health. Further longitudinal studies are needed to support our results and should include control groups that use conventional removable dentures.
Stress a determinant for bruxism in medical students-a qualitative and quantitative assessment.
Authors: Dhakar Neelam 
Published: September 2024

Abstract-
Background-Bruxism is an oral habit consisting of involuntary rhythmic or spasmodic nonfunctional gnashing, grinding, or clenching of teeth, unlike chewing movements of the mandible, which may lead to occlusal trauma. There are many scientific reports about the coexistence of bruxism, stress.
Objective- the purpose of this study is to assess the development of symptoms of bruxism due to stress in medical students and to evaluate the correlation between occurrence of bruxism and perceived stress.
Methodology- A mixed method survey questionnaire was prepared regarding questions based on scientific evidence of co-relation between bruxism, stress and stress faced by medical students. This survey based questionnaire was circulated digitally pan India and the respondents were undergraduate, post graduate students and junior and senior residents from different medical institutions. Therefore a random sample of 300 participants was selected, and gender, age, stress factors specific results were derived.

Result- 14.7% of students are suffering from moderate bruxism and 85.3% of students suffering from severe bruxism due to stress.
The test result showed that stress was main factor affecting the habit of bruxism with chi square value 12.39 and p value is 0.006.
Conclusion- The study found that majority of the participating medical students reported to have bruxism majorly due to stress and Corelated variables majorly responsible for stress are large course of study, competition in this field, overthinking about the study related problems and uncertainty of result what is expected and do not feel happy with their own work performance.
The Essential Guide to Managing morphological oddity of Two-rooted Mandibular Premolar: A case report with review of 10 years incidence
Authors: Dua Rasleen , Gangwar Anshul , De Sriparna 
Published: September 2024

Introduction- The root canal morphology of teeth is often extremely complex and highly variable. One such morphological oddity is the presence of two roots, with a reported incidence of 1.8%.
Case- A 16-year-old female patient complains of pain in the posterior left mandibular tooth for the past 2 weeks. After clinical, radiographic examination, and vitality testing, we diagnosed the patient with Acute apical periodontitis of tooth #34. It was decided to treat the left mandibular first premolar with two roots endodontically. The patient was reviewed after 1 month, 3 months, 6 months , 1 year and radiographs showed satisfactory healing.
Conclusion- This case report details the endodontic management of a sparse case of mandibular first premolar with two roots and two canals, which ended with a favorable outcome due to the satisfactory execution of the preferred constituents.
Polymorphism of antioxidant defense genes as a predictor of unfavorable neurological outcomes in preterm children
Authors: Savchenko O. A. , Pavlinova E. B. 
Published: September 2024

Currently, oxidative stress is considered as one of the most important factors in the pathogenesis of many pathological processes occurring in the newborn baby. Purpose. To establish the relationship of the polymorphism of genes, encoding antioxidant enzymes (glutamyl cysteine ligase, manganine superoxide dismutase) with unfavorable neurological outcomes in preterm children at various age periods. Material and methods. A prospective cohort continuous study included 151 preterm children, with a gestational age of 26–32 weeks and body weight of 590–1990 grams. Cord blood was sampled in children to determine allelic polymorphisms of 4 genetic markers: the SOD2 gene rs4880 (с.47C>Т, р.Ala16Val), the SOD2 gene rs1141718 (с.58T>C, р.Thr58Ile), the SOD2 gene rs11575993 (с.60С>Т, р.Leu58Phe), GCLC gene rs17883901 (с.–129 С>Т). The division of children into groups was carried out based on the assessment of neurological outcomes at the following control points: 1 control point — at the time of discharge from hospital, 2 control point — corrected age of 1 year of life, 3 control point — 4 years of life. Results. The cohort of children with unfavorable neurological outcomes was found to increase from 36.4 % at the time of hospital discharge to 70 % by the age of 4 years. Children who joined the cohort of children with unfavorable neurological outcomes at corrected age of 1 year of life were carriers of 47 CT of the gene of the mitochondrial superoxide dismutase (SOD2) rs4880, and those, attached by 4 years of age, were carriers of heterozygous 129 CT genotype of the gene of the catalytic subunit of glutamate cysteine ligase (GCLC) rs17883901 and 47 CT mitochondrial superoxide dismutase (SOD2) rs4880. Children with a favorable neurological outcome at corrected age of 1 year of life were more often diagnosed with homozygous 47 CC genotype of SOD2 rs4880 and 60 CC SOD2 rs11575993, and at the age of 4 years of life — with homozygous 129 CC genotype of GCLC rs17883901 gene and 47 TTSOD2 rs4880. Conclusion. The study of single nucleotide exchange in the antioxidant enzyme genes will establish the risk group of children exposed to free-radical injuries of CNS and begin neuroprotective therapy with the inclusion of antioxidant treatment.