bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compassion focussed working in secure forensic care
Authors: Taylor Jon 
Published: October 2017

Purpose
The purpose of this paper is to describe practices associated with compassion focussed therapy (CFT) in a secure forensic setting for men with a learning disability and personality disorder. The values of this model for both therapeutic work and the organisation of residential practices in a secure setting are considered.

Design/methodology/approach
The paper presents a conceptual discussion of the use of CFT with an offender population.

Findings
The paper describes the use of CFT as a framework for working with offenders with an intellectual disability and personality disorder. The paper discusses the organisation of service practices alongside more formal therapeutic interventions.

Practical implications
CFT offers a unique integrated model for working with offenders. The core CFT model invites staff teams to consider the safety seeking aspects of challenging behaviours and to understand these behaviours in the context of evolved threat processing mechanisms. The focus on emotional processing that is central to the model invites services to develop deep understanding of the functions of violence and other offending behaviours and to balance work in these areas alongside the development of capacities that offer individuals methods for effective emotional regulation.

Originality/value
The paper provides a unique discussion point for the organisation of forensic services for this population. The consideration of the wider social context of offender rehabilitation in terms of the residential settings, and the juxtaposition of this with formal treatments is rarely considered.
Making a splash
Authors: Sciulli Nick 
Published: October 2017

Purpose
The purpose of this study is to investigate how accountability and transparency was used to inform the local community and support the decision-making of the Surf Coast Shire (SCS) with respect to the development of an aquatic and health centre.

Design/methodology/approach
This project investigates a case study of a proposed aquatic and leisure centre located within the SCS (Victoria-Australia). The paper draws on content analysis and an interpretative approach to critically analyse publicly available archival documents sourced from the SCS, consultant reports and the popular press.

Findings
Providing extensive disclosure for a major capital works project and engaging the community to determine support for such a project was undertaken for reasons of accountability and transparency. However, community feedback has provided evidence of divisions between and within local township communities.

Practical implications
This project illustrates that being transparent and communicating accounting information via different forums can create significant community engagement to facilitate council decision-making albeit at a cost to some social disharmony.

Originality/value
It is typical for local councils to prepare budgets that inform the community how funds will be expended. In this case, the council has sought feedback from the community before a capital-intensive decision has been made. This approach extends the notion of accountability by disclosing managements’ decision-making apparatus.
Dawn song in natural and artificial continuous day: Light pollution affects songbirds at high latitudes
Authors: Derryberry Elizabeth P. 
Published: October 2017

AbstractIn Focus: Da Silva, A., & Kempenaers, B. (2017). . Journal of Animal Ecology, 86, 1286–1297. doi: 10.1111/1365-2656.12739Satellite images of the world at night show bright dots connected by glowing lines crisscrossing the globe. As these connect‐the‐dots become brighter and expand into more and more remote regions, much of the flora and fauna of the world are experiencing evolutionarily unprecedented levels of light at night. Light cues are essential to most physiological and behavioural processes, and so the need to measure the effects of light pollution on these processes is critical. In this issue, Da Silva and Kempenaers take on this task using an important reproductive behaviour in songbirds—dawn song. The geographic, temporal and taxonomic breadth of sampling in this study allows for a close examination of a potentially complex interaction between light pollution and natural variation in the behaviour of dawn singing across latitude, season and species. Their extensive dataset highlights complexity in how songbirds respond to light pollution. Although light pollution has a strong effect on the timing of dawn song, not all songbirds respond the same way to light pollution, and the effects of light pollution vary with changes in natural light levels. Early dawn singers show more flexibility in the timing of dawn song across the season and across latitudes than late dawn singers, and also appear less affected by light pollution at high latitudes than are late dawn singers. These findings suggest that not all songbirds are responding to artificial continuous daylight as they do to natural continuous daylight, highlighting the general need to measure the fitness effects of light pollution.
The Scottish Union Bill of 1656–7
Authors: Little Patrick 
Published: October 2017

AbstractThe Scottish Union Bill introduced to the second Protectorate Parliament in October 1656 was based on the union ordinance of 1654, but it was then subjected to wide‐ranging amendments over the next few months. These amendments made many concessions to the Scots, including recognizing their separate legal system and the rights of the burghs, and allowing an expansion of free trade. This article explores the implications of these changes to the constitutional relationship between the two nations, and identifies the changes with a programme of reform championed by the Scottish council, led by Lord Broghill. The fate of the Union Bill thus became linked to the wider reform movement that saw the replacement of the Instrument of Government with the more moderate, civilian constitution known as the Humble Petition and Advice in the spring of 1657.
Peers, Politics and the Price of Pepper: Skinner v. the East India Company
Authors: Paley Ruth 
Published: October 2017

AbstractThe case of Thomas Skinner v. the East India Company brought parliament to a standstill in 1668 in a confrontation between the Houses over their respective privileges that lasted nearly two years. There is no doubt that the case was exploited for political advantage by presbyterians anxious to block the passage of a new conventicles act, but that is far from being the whole story. This article examines for the first time the details of the case and reliability of Skinner's claims against the East India Company. It reveals that Thomas Skinner was somewhat of an obsessive fantasist who, far from being a presbyterian sympathiser, was close to the household of James, duke of York. At one stage his daughter was even reputed to be the mother of the ‘pretended’ prince of Wales. It concludes that Skinner was himself an unscrupulous opportunist, eager to exploit political and commercial uncertainty for private gain.
Crowding as a primary source of stress in an endangered fragment‐dwelling strepsirrhine primate
Authors: Gabriel D. N. , Gould L. , Cook S. 
Published: October 2017

AbstractNutritional and social challenges arising from habitat fragmentation can be significant sources of stress for animals. If prolonged, such stressors can pose a threat to the longevity of a species within a fragmented landscape. While each may elicit a physiological response, the coupled and often additive nature of these stressors can make it difficult to determine their relative impact on an individual or population. We measured fecal glucocorticoids (fGC) in two populations of Lemur catta, an endangered strepsirrhine primate, inhabiting forest fragments that vary markedly in resource structure and population density. We also examined the relative importance of behavioral variables indicative of feeding environment, intergroup territoriality, and intragroup social interactions in predicting fGC levels in these populations. Lemur catta living with ample food resources but at high population density exhibited higher fGC concentrations throughout the study period, independent of sex or reproductive state. At both sites, fGC levels reflected consistent seasonal variation, with lowest levels occurring during the resource‐rich pre‐mating period. Foraging effort was positively associated with fGC levels at each site, yet the population exhibiting the highest foraging effort had consistently lower levels of fGC. Intergroup territoriality was a positive predictor and intragroup agonism a negative predictor of fGC levels; however, trends in these variables were inconsistent when examining the two sites separately. Within‐site group differences highlighted the additive nature of nutritional and social stressors in predicting fGC levels. Our results suggest that the intense or unpredictable impact of crowding and, correspondingly, heightened intergroup resource defense may be an important consideration when addressing long‐term conservation initiatives for fragment‐dwelling L. catta.
Beneficial effect of exogenous platelet factor 4 for detecting pathogenic heparin‐induced thrombocytopenia antibodies
Authors: Vayne Caroline , Guery Eve‐Anne , Kizlik‐Masson Claire , Rollin Jérôme , Bauters Anne , Gruel Yves , Pouplard Claire 
Published: October 2017

SummaryThe laboratory diagnosis of heparin‐induced thrombocytopenia (HIT) is based on an enzyme immunoassay combined with a functional test, and serotonin release assay (SRA) is the gold standard for detecting activating HIT antibodies. However, a recent atypical history of HIT prompted us to evaluate whether addition of platelet factor 4 (PF4) during SRA could improve its ability to detect pathogenic HIT antibodies. Using 5B9, a monoclonal antibody to PF4/H with a human Fc fragment, we first defined the optimal PF4 concentration for detecting low amounts of platelet‐activating IgG with SRA. Plasma samples from 50 patients with suspected HIT were then studied, and SRA was positive in 17 cases (Group SRApos), with relatively high levels of PF4‐specific IgG (median optical density = 2·66). SRA was also systematically performed after adding 10 μg/ml of PF4 in the reaction mixture, and significant serotonin release was measured with samples from 9 additional patients (Group PF4‐SRApos). Importantly, levels of PF4‐specific IgG were similar in these samples and those from the 24 persistently SRA negative patients. Moreover, the pre‐test probability of HIT was intermediate/high in all ‘SRApos’ or ‘SRA‐PF4pos’ patients. In conclusion, addition of exogenous PF4 might improve the detection of pathogenic HIT antibodies by SRA.
Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open‐label trial
Authors: Nozza Andrea , Terenghi Fabrizia , Gallia Francesca , Adami Fausto , Briani Chiara , Merlini Giampaolo , Giordano Laura , Santoro Armando , Nobile‐Orazio Eduardo 
Published: October 2017

SummaryGiven its anti‐angiogenic activity, lenalidomide may have a role in the treatment of POEMS (Peripheral neuropathy, Organomegaly, Endocrinopathy, Monoclonal plasma cell disorder and Skin changes) syndrome. This prospective, open‐label, pilot study evaluated the combination of lenalidomide + dexamethasone (RD) in 18 POEMS syndrome patients (13 pre‐treated, 5 newly‐diagnosed but ineligible for high‐dose therapy). Treatment consisted of six cycles of lenalidomide (25 mg/day for 21 days followed by 7 days rest) plus dexamethasone (40 mg/once a week). Patients responding after six cycles continued treatment until progression or unbearable toxicity. The primary endpoint was the proportion of patients with either neurological or clinical improvement. The RD combination was considered as deserving further evaluation if 9 of the first 15 patients responded. Ten responses were observed among the first 15 enrolled patients, meeting the primary endpoint. Fifteen of 18 patients (83%) completed six RD cycles: 13 (72%) patients responded and nine had both clinical and neurological improvement. Among the 15 patients who completed the six RD cycles, four were still on treatment after a 25‐month follow‐up. At 39 months of follow‐up, all patients were alive with a 3‐year progression‐free survival of 59%. No patient discontinued RD for toxicity. Overall, the RD regimen showed a high incidence of prolonged symptoms improvement and was well tolerated in most POEMS patients.
Recurrent cardiotoxicity potentiated by the interaction of proteasome inhibitor and immunomodulatory therapy for the treatment of multiple myeloma
Authors: Fradley Michael G. , Groarke John D. , Laubach Jacob , Alsina Melissa , Lenihan Daniel J. , Cornell Robert F. , Maglio Michelle , Shain Kenneth H. , Richardson Paul G. , Moslehi Javid 
Published: October 2017

SummaryPatients with multiple myeloma (MM) have improved treatment options, including immunomodulatory drugs (IMiDs) and proteasome inhibitors (PIs). Despite their efficacy, increased rates of cardiovascular (CV) complications occur in patients exposed to some of these therapies. While previous research has focused on identifying the toxicities inherent to each specific agent, the CV side effects may be potentiated by the combination of PIs and IMiDs plus dexamethasone. We present a patient with MM with recurrent cardiotoxicity only when exposed to combination PI and IMiD‐based therapy. We also review the literature in this context, and propose a potential algorithm for cardiotoxicity prevention in this population.
The wisdom of demagogues: institutions, corruption and support for authoritarian populists
Authors: Rohac Dalibor , Kumar Sahana , Johansson Heinö Andreas 
Published: October 2017

AbstractThis article analyses the drivers of support for authoritarian populist parties in Europe. Such parties claim to represent the interests of ordinary people against greedy and out‐of‐touch elites. Simultaneously, they reject conventional constraints on democratic policymaking. In recent years, such parties on the political left and right have been gaining influence in countries across Europe. Using a panel data set from 1980–2016, we use semiparametric Tobit models with country fixed effects to explain support for authoritarian populists. We find that large vote shares of right‐wing – but not left‐wing – authoritarian populists are associated closely to corruption. Other commonly cited explanations such as unemployment, inequality and immigration perform poorly in predicting support for populist political platforms on the political right. While a full theoretical explanation of the link between corruption and right‐wing populism remains beyond the scope of this article, we suggest that the mechanism involves political trust. Corruption weakens trust in political institutions, which populists exploit. Curbing the rise of right‐wing authoritarian populism in Europe will thus require restoring trust in the integrity of politics.
The impact of passive smoking on the risk of colorectal neoplasia in never, former, and current smokers
Authors: Jung Yoon Suk , Kim Nam Hee , Yang Hyo‐Joon , Park Soo‐Kyung , Park Jung Ho , Park Dong Il , Sohn Chong Il 
Published: October 2017

AbstractBackground and AimActive smoking is well known to be a risk factor for colorectal neoplasia (CRN). However, it remains unclear whether passive smoking is also related to the risk of CRN. This study investigated the effect of passive smoking on the risk of CRN in never, former, and current smokers.MethodsA cross‐sectional study was performed on asymptomatic examinees who underwent colonoscopy as part of a health check‐up.ResultsOf 136 707 participants, 33 052 (24.2%) were never passive smokers, and 103 655 (75.8%) were ever passive smokers. The mean age of the study population was 41.0 years. The proportion of never, former, and current smokers was 56.9%, 21.4%, and 24.8%, respectively, and the proportion of overall CRN and advanced CRN (ACRN) was 15.4% and 1.7%, respectively. Ever passive smoke exposure was associated with an increased risk of overall CRN in never smokers (adjusted odds ratio [AOR] 1.08; 95% confidence interval [CI] 1.02–1.13) and former smokers (AOR 1.08; 95% CI 1.00–1.17) but not in current smokers (AOR 1.02; 95% CI 0.94–1.11). Additionally, it significantly increased the risk of ACRN among never smokers (AOR 1.17; 95% CI 1.01–1.35) and tended to increase the risk of ACRN among former smokers (AOR 1.26; 95% CI 0.99–1.61). Moreover, the risk of CRN increased with increasing frequency and duration of passive smoking in never and former smokers.ConclusionsPassive smoking was an independent risk factor for CRN in never and former smokers. Never and former smokers who are highly exposed to passive smoke as well as current smokers should be given priority for colonoscopy.
Effect of the midazolam added with propofol‐based sedation in esophagogastroduodenoscopy: A randomized trial
Authors: Kim Eun Hye , Park Jun Chul , Shin Sung Kwan , Lee Yong Chan , Lee Sang Kil 
Published: October 2017

AbstractBackground and AimAlthough propofol has been widely used for sedation during esophagogastroduodenoscopy (EGD), adverse events including hypoxia and hypotension may be a concern in the propofol‐based sedation. We aimed to analyze whether administration of midazolam would improve safety and efficacy of propofol‐based sedation in EGD.MethodsOne hundred twenty patients who were scheduled to undergo diagnostic EGD were randomly assigned to either midazolam plus propofol (MP) or propofol alone groups. In the MP group, 2 mg of midazolam and 10 mg of propofol were given initially. In the propofol alone group, 40–60 mg of propofol was given initially. In both groups, 20 mg of propofol was given repeatedly to maintain moderate sedation as needed. Vital signs including oxygen saturation were monitored every 2 min. After the patients fully recovered, satisfaction score was investigated from endoscopists, nurses, and patients, respectively.ResultsThe baseline characteristics did not differ between the MP and propofol alone groups. The mean required doses of propofol was (mean ± standard deviation) 0.3 ± 0.3 and 0.8 ± 0.2 mg/kg in the MP and propofol alone groups, respectively (P < 0.001). In addition, sedation‐related adverse events and recovery time did not differ between the two groups. The proportion of satisfactory did not differ between the two groups (MP vs propofol alone; proportion; patient, 95.0% vs 93.3%, P > 0.999; endoscopist, 73.3% vs 80.0%, P = 0.064; nurse, 73.3% vs 76.7%, P = 0.551).ConclusionAdding midazolam to propofol did not reduced the safety and efficacy, and sedation using propofol alone could be suitable for sedation during diagnostic EGD.
Retracted: Intra‐arterial transplantation of human bone marrow mesenchymal stem cells (hBMMSCs) improves behavioral deficits and alters gene expression in rodent stroke model
Authors: Vibhuti  , Khan Rehan , Sharma Alpana , Jain Suman , Mohanty Sujata , Prasad Kameshwar 
Published: October 2017

AbstractStroke is a multi‐factorial polygenic disease and is a major cause of death and adult disability. Administration of bone marrow stem cells protects ischemic rat brain by facilitating recovery of neurological functions. But the molecular mechanism of stem cells action and their effect on gene expression is not well explored. In this study, we have transplanted 1 × 106 human bone marrow mesenchymal stem cells (hBMMSCs) in middle cerebral artery occluded (MCAo) adult male Wistar rats through intracarotid artery route at 24 h after surgery. Motor behavioral tests (rotarod and open field) were performed to assess the changes in motor functions at day 0 and day1, 4, 8 and 14. The expression of studied genes at mRNA and protein level was quantified by using Q‐PCR and western blotting, respectively. Further, we have assessed the methylation pattern of promoter of these genes by using methylation‐specific PCR. Data were analyzed statistically and correlated. A significant improvement in behavioral deficits was observed in stem cells treated group after 14th day post stroke. Significantly (p < 0.05) increased mRNA and protein levels of brain derived neurotrophic factor and ANP genes in hBMMSCs treated group along with decrease in methylation level at their promoter was observed. On the other hand, significantly decreased mRNA and protein level of TSP1 and WNK1 in hBMMSCs treated group was observed. In conclusion, hBMMSCs administration significantly improves the behavioral deficits by improving motor and locomotor coordination. The promoter of TSP1 and WNK1 genes was found to be hyper‐methylated in hBMMSCs group resulting in their decreased expression while the promoter of ANP and brain derived neurotrophic factor was found to be hypo‐methylated. This study might shed a light on how hBMMSCs affect the gene expression by modulating methylation status.
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Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6
Authors: Zorrilla‐Zubilete María A. , Yeste Ada , Quintana Francisco J. , Toiber Debra , Mostoslavsky Raul , Silberman Dafne M. 
Published: October 2017

AbstractDiabetic retinopathy (DR) is one of the common complications associated with diabetes mellitus and the leading cause of blindness worldwide. Recent research has demonstrated that DR is not only a microvascular disease but may be a result of neurodegenerative processes. Moreover, glucose‐induced neuron and glial cell damage may occur shortly after the onset of diabetes which makes the disease hard to diagnose at early stages. SIRT6, a NAD‐dependent sirtuin deacylase, modulates aging, energy metabolism, and neurodegeneration. In previous studies we showed that SIRT6 deficiency causes major retinal transmission defects, changes in the expression of glycolytic genes, and elevated levels of apoptosis. Given the importance of glucose availability for retinal function and the critical role of SIRT6 in modulating glycolysis, we aimed to analyze SIRT6 participation in the molecular machinery that regulates the development of experimental DR. Using non‐obese diabetic mice, we determined by western blot that 2 weeks after the onset of the disease, high glucose concentrations induced retinal increase in a neovascularization promoting factor (vascular endothelial growth factor, VEGF), and the loss of a neuroprotective factor (brain‐derived neurotrophic factor, BDNF) associated with reduced levels of SIRT6 and increased acetylation levels of its substrates (H3K9 and H3K56) suggesting a deregulation of key neural factors. Noteworthy, retinas from CNS conditionally deleted SIRT6 mice showed a resemblance to diabetic retinas exhibiting lower protein levels of BDNF factor and increased protein levels of VEGF. Moreover, cultured Müller glial cells subjected to high glucose concentrations exhibited decreased levels of SIRT6 and increased levels of H3K56 acetylation. In addition, the increment of VEGF levels induced by high glucose was reverted by the over‐expression of SIRT6 in this cell type. Accordingly, siRNA experiments showed that, when SIRT6 was silenced, VEGF levels increased. Our findings suggest that epigenetically regulated neurodegenerative events may occur at an early diabetic stage prior to the characteristic proliferative and vascular changes observed at a later diabetic stage.
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