bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Theoretical Perspective on the Formation and Fragmentation of Protostellar Discs
Authors: Whitworth A. , Lomax O. 
Published: January 2016

AbstractWe discuss the factors influencing the formation and gravitational fragmentation of protostellar discs. We start with a review of how observations of prestellar cores can be analysed statistically to yield plausible initial conditions for simulations of their subsequent collapse. Simulations based on these initial conditions show that, despite the low levels of turbulence in prestellar cores, they deliver primary protostars and associated discs which are routinely subject to stochastic impulsive perturbations; consequently misalignment of the spins and orbits of protostars are common. Also, the simulations produce protostars that collectively have a mass function and binary statistics matching those observed in nearby star-formation regions, but only if a significant fraction of the turbulent energy in the core is solenoidal, and accretion onto the primary protostar is episodic with a duty cycle $\stackrel{>}{\sim }3\,000\,{\rm yr}$. Under this circumstance, a core typically spawns between 4 and 5 protostars, with high efficiency, and the lower mass protostars are mainly formed by disc fragmentation. The requirement that a proto-fragment in a disc lose thermal energy on a dynamical timescale dictates that there is a sweet spot for disc fragmentation at radii $70\,{\rm AU}\stackrel{<}{\sim }R\stackrel{<}{\sim }100\,{\rm AU}$ and temperatures $10\,{\rm K}\stackrel{<}{\sim }T\stackrel{<}{\sim }20\,{\rm K}$, and this might explain the brown dwarf desert.
Preliminary Investigation on the Rapid and Direct AMS Measurement of 129I in Environmental Samples without Chemical Separation
Authors: Liu Qi , Zhao Xiaolei , Hou Xiaolin , Burr George , Zhou Weijian , Fu Yunchong , Chen Ning , Zhang Luyuan 
Published: January 2016

AbstractAccelerator mass spectrometry (AMS) is the most sensitive method for measuring 129I in environmental samples available today, with a detection limit of about 10–15 for 129I/127I. A drawback of the technique is the time-consuming chemical separation required to prepare AMS targets from raw samples. This step significantly limits applications requiring rapid analyses and large numbers of samples, for example, in monitoring studies associated with nuclear accidents. This work introduces a direct method for 129I measurements by AMS that does not require chemical separation. In this approach, stable iodine (127I) is added to a matrix of niobium (Nb) powder and mixed with dried raw sample. This mixture is pressed directly into a sputter target for AMS analysis. Two types of environmental samples have been tested in this work, seaweed and sediment. No anomalous behavior was noted in the Cs+ sputtering behavior of the targets prepared from these materials. The 129I/127I ratios and 129I concentrations measured by this rapid method were found to be in agreement with reported values that used a conventional AMS method for the same material. Based on our findings, we expect that such rapid measurements can be applied to a wide variety of materials, in addition to seaweed and sediment, as long as the sputtering-induced adverse effects do not prevent the stable operation of the ion source. The method is especially useful for screening large numbers of samples before more precise analyses are made.
Statistical procedures for testing hypotheses of equivalence in the safety evaluation of a genetically modified crop
Authors: KANG Q. , VAHL C. I. 
Published: January 2016

SUMMARYSafety evaluation of a genetically modified crop entails assessing its equivalence to conventional crops under multi-site randomized block field designs. Despite mounting petitions for regulatory approval, there lack a scientifically sound and powerful statistical method for establishing equivalence. The current paper develops and validates two procedures for testing a recently identified class of equivalence uniquely suited to crop safety. One procedure employs the modified large sample (MLS) method; the other is based on generalized pivotal quantities (GPQs). Because both methods were originally created under balanced designs, common issues associated with incomplete and unbalanced field designs were addressed by first identifying unfulfilled theoretical assumptions and then replacing them with user-friendly approximations. Simulation indicated that the MLS procedure could be very conservative in many occasions irrespective of the balance of the design; the GPQ procedure was mildly liberal with its type I error rate near the nominal level when the design is balanced. Additional pros and cons of these two procedures are also discussed. Their utility is demonstrated in a case study using summary statistics derived from a real-world dataset.
Morphometrics and molecular analysis of the free-living nematode, Belondira bagongshanensis n. sp. (Dorylaimida, Belondiridae), from China
Authors: Wu W.J. , Huang X. , Xie H. , Wang K. , Xu C.L. 
Published: January 2016

AbstractA new species, Belondira bagongshanensis n. sp., extracted from soil under grass in Bagongshan Forest Park, Anhui Province, China, is described and illustrated. The new species is mainly characterized by a body length 1.6–2.1 mm; cephalic framework moderately sclerotized; odontostyle robust with a distinct lumen; anterior part of pharynx with a distinct fusiform swelling, bearing distinct sclerotized valve plates and basal expansion occupying about three-fifths of the total neck length; female genital system mono-opisthodelphic and anterior branch 0.8–1.6 times the corresponding body diameter; tail short and hemispheroid; male spicules 36–49 μm long and two widely spaced ventromedian supplements. The new species is close to B. wajahati, B. golden and B. eugeniae in possessing a short tail, a robust odontostyle with a distinct aperture and a moderately sclerotized cephalic framework. New sequences of 18S rDNA and the D2–D3 region of 28S rDNA of the new species were also identified.
Probabilistic Divide-and-Conquer: A New Exact Simulation Method, With Integer Partitions as an Example
Authors: ARRATIA RICHARD , DeSALVO STEPHEN 
Published: January 2016

We propose a new method, probabilistic divide-and-conquer, for improving the success probability in rejection sampling. For the example of integer partitions, there is an ideal recursive scheme which improves the rejection cost from asymptotically ordern3/4to a constant. We show other examples for which a non-recursive, one-time application of probabilistic divide-and-conquer removes a substantial fraction of the rejection sampling cost.We also present a variation of probabilistic divide-and-conquer for generating i.i.d. samples that exploits features of the coupon collector's problem, in order to obtain a cost that is sublinear in the number of samples.
Psychosocial constructs were not mediators of intervention effects for dietary and physical activity outcomes in a church-based lifestyle intervention: Delta Body and Soul III
Authors: Thomson Jessica L , Tussing-Humphreys Lisa M , Zoellner Jamie M , Goodman Melissa H 
Published: January 2016

AbstractObjectiveEvaluating an intervention’s theoretical basis can inform design modifications to produce more effective interventions. Hence the present study’s purpose was to determine if effects from a multicomponent lifestyle intervention were mediated by changes in the psychosocial constructs decisional balance, self-efficacy and social support.DesignDelta Body and Soul III, conducted from August 2011 to May 2012, was a 6-month, church-based, lifestyle intervention designed to improve diet quality and increase physical activity. Primary outcomes, diet quality and aerobic and strength/flexibility physical activity, as well as psychosocial constructs, were assessed via self-report, interviewer-administered surveys at baseline and post intervention. Mediation analyses were conducted using ordinary least squares (continuous outcomes) and maximum likelihood logistic (dichotomous outcomes) regression path analysis.SettingChurches (five intervention and three control) were recruited from four counties in the Lower Mississippi Delta region of the USA.SubjectsRural, Southern, primarily African-American adults (n 321).ResultsBased upon results from the multiple mediation models, there was no evidence that treatment (intervention v. control) indirectly influenced changes in diet quality or physical activity through its effects on decisional balance, self-efficacy and social support. However, there was evidence for direct effects of social support for exercise on physical activity and of self-efficacy for sugar-sweetened beverages on diet quality.ConclusionsResults do not support the hypothesis that the psychosocial constructs decisional balance, self-efficacy and social support were the theoretical mechanisms by which the Delta Body and Soul III intervention influenced changes in diet quality and physical activity.
Octanol-assisted liposome assembly on chip
Authors: Deshpande Siddharth , Caspi Yaron , Meijering Anna E. C. , Dekker Cees 
Published: January 2016

AbstractLiposomes are versatile supramolecular assemblies widely used in basic and applied sciences. Here we present a novel microfluidics-based method, octanol-assisted liposome assembly (OLA), to form monodisperse, cell-sized (5–20 μm), unilamellar liposomes with excellent encapsulation efficiency. Akin to bubble blowing, an inner aqueous phase and a surrounding lipid-carrying 1-octanol phase is pinched off by outer fluid streams. Such hydrodynamic flow focusing results in double-emulsion droplets that spontaneously develop a side-connected 1-octanol pocket. Owing to interfacial energy minimization, the pocket splits off to yield fully assembled solvent-free liposomes within minutes. This solves the long-standing fundamental problem of prolonged presence of residual oil in the liposome bilayer. We demonstrate the unilamellarity of liposomes with functional α-haemolysin protein pores in the membrane and validate the biocompatibility by inner leaflet localization of bacterial divisome proteins (FtsZ and ZipA). OLA offers a versatile platform for future analytical tools, delivery systems, nanoreactors and synthetic cells.
Large deglacial shifts of the Pacific Intertropical Convergence Zone
Authors: Jacobel A. W. , McManus J. F. , Anderson R. F. , Winckler G. 
Published: January 2016

AbstractThe position of the Intertropical Convergence Zone (ITCZ) is sensitive to changes in the balance of heat between the hemispheres which has fundamental implications for tropical hydrology and atmospheric circulation. Although the ITCZ is thought to experience the largest shifts in position during deglacial stadial events, the magnitude of shifts has proven difficult to reconstruct, in part because of a paucity of high-resolution records, particularly those including spatial components. Here we track the position of the ITCZ from 150 to 110 ka at three sites in the central equatorial Pacific at sub-millennial time resolution. Our results provide evidence of large, abrupt changes in tropical climate during the penultimate deglaciation, coincident with North Atlantic Heinrich Stadial 11 (∼136–129 ka). We identify this event both as a Northern Hemisphere increase in aeolian dust and as a shift in the mean position of the ITCZ a minimum of 4° southwards at 160° W.
p38γ and δ promote heart hypertrophy by targeting the mTOR-inhibitory protein DEPTOR for degradation
Authors: González-Terán Bárbara , López Juan Antonio , Rodríguez Elena , Leiva Luis , Martínez-Martínez Sara , Bernal Juan Antonio , Jiménez-Borreguero Luis Jesús , Redondo Juan Miguel , Vazquez Jesús , Sabio Guadalupe 
Published: January 2016

AbstractDisrupted organ growth leads to disease development. Hypertrophy underlies postnatal heart growth and is triggered after stress, but the molecular mechanisms involved in these processes are largely unknown. Here we show that cardiac activation of p38γ and p38δ increases during postnatal development and by hypertrophy-inducing stimuli. p38γ/δ promote cardiac hypertrophy by phosphorylating the mTORC1 and mTORC2 inhibitor DEPTOR, which leads to its degradation and mTOR activation. Hearts from mice lacking one or both kinases are below normal size, have high levels of DEPTOR, low activity of the mTOR pathway and reduced protein synthesis. The phenotype of p38γ/δ−/− mice is reverted by overactivation of mTOR with amino acids, shRNA-mediated knockdown of Deptor, or cardiomyocyte overexpression of active p38γ and p38δ. Moreover, in WT mice, heart weight is reduced by cardiac overexpression of DEPTOR. Our results demonstrate that p38γ/δ control heart growth by modulating mTOR pathway through DEPTOR phosphorylation and subsequent degradation.
Lipid metabolic reprogramming in cancer cells
Authors: Beloribi-Djefaflia S , Vasseur S , Guillaumond F 
Published: January 2016

AbstractMany human diseases, including metabolic, immune and central nervous system disorders, as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their pathways. This illustrates the fundamental role played by lipids in maintaining membrane homeostasis and normal function in healthy cells. We reviewed the major lipid dysfunctions occurring during tumor development, as determined using systems biology approaches. In it, we provide detailed insight into the essential roles exerted by specific lipids in mediating intracellular oncogenic signaling, endoplasmic reticulum stress and bidirectional crosstalk between cells of the tumor microenvironment and cancer cells. Finally, we summarize the advances in ongoing research aimed at exploiting the dependency of cancer cells on lipids to abolish tumor progression.
Hypoxia and metabolic adaptation of cancer cells
Authors: Eales K L , Hollinshead K E R , Tennant D A 
Published: January 2016

AbstractLow oxygen tension (hypoxia) is a pervasive physiological and pathophysiological stimulus that metazoan organisms have contended with since they evolved from their single-celled ancestors. The effect of hypoxia on a tissue can be either positive or negative, depending on the severity, duration and context. Over the long-term, hypoxia is not usually consistent with normal function and so multicellular organisms have had to evolve both systemic and cellular responses to hypoxia. Our reliance on oxygen for efficient adenosine triphosphate (ATP) generation has meant that the cellular metabolic network is particularly sensitive to alterations in oxygen tension. Metabolic changes in response to hypoxia are elicited through both direct mechanisms, such as the reduction in ATP generation by oxidative phosphorylation or inhibition of fatty-acid desaturation, and indirect mechanisms including changes in isozyme expression through hypoxia-responsive transcription factor activity. Significant regions of cancers often grow in hypoxic conditions owing to the lack of a functional vasculature. As hypoxic tumour areas contain some of the most malignant cells, it is important that we understand the role metabolism has in keeping these cells alive. This review will outline our current understanding of many of the hypoxia-induced changes in cancer cell metabolism, how they are affected by other genetic defects often present in cancers, and how these metabolic alterations support the malignant hypoxic phenotype.
Characterization of Adsorption Enthalpy of Novel Water-Stable Zeolites and Metal-Organic Frameworks
Authors: Kim Hyunho , Cho H. Jeremy , Narayanan Shankar , Yang Sungwoo , Furukawa Hiroyasu , Schiffres Scott , Li Xiansen , Zhang Yue-Biao , Jiang Juncong , Yaghi Omar M. , Wang Evelyn N. 
Published: January 2016

AbstractWater adsorption is becoming increasingly important for many applications including thermal energy storage, desalination and water harvesting. To develop such applications, it is essential to understand both adsorbent-adsorbate and adsorbate-adsorbate interactions and also the energy required for adsorption/desorption processes of porous material-adsorbate systems, such as zeolites and metal-organic frameworks (MOFs). In this study, we present a technique to characterize the enthalpy of adsorption/desorption of zeolites and MOF-801 with water as an adsorbate by conducting desorption experiments with conventional differential scanning calorimetry (DSC) and thermogravimetric analyzer (TGA). With this method, the enthalpies of adsorption of previously uncharacterized adsorbents were estimated as a function of both uptake and temperature. Our characterizations indicate that the adsorption enthalpies of type I zeolites can increase to greater than twice the latent heat whereas adsorption enthalpies of MOF-801 are nearly constant for a wide range of vapor uptakes.
Highly photoresponsive and wavelength-selective circularly-polarized-light detector based on metal-oxides hetero-chiral thin film
Authors: Lee Seung Hee , Singh Dhruv Pratap , Sung Ji Ho , Jo Moon-Ho , Kwon Ki Chang , Kim Soo Young , Jang Ho Won , Kim Jong Kyu 
Published: January 2016

AbstractA highly efficient circularly-polarized-light detector with excellent wavelength selectivity is demonstrated with an elegant and simple microelectronics-compatible way. The circularly-polarized-light detector based on a proper combination of the geometry-controlled TiO2-SnO2 hetero-chiral thin film as an effective chiroptical filter and the Si active layer shows excellent chiroptical response with external quantum efficiency as high as 30% and high helicity selectivity of ~15.8% in an intended wavelength range. Furthermore, we demonstrated the ability of manipulating both bandwidth and responsivity of the detector simultaneously in whole visible wavelength range by a precise control over the geometry and materials constituting hetero-chiral thin film. The high efficiency, wavelength selectivity and compatibility with conventional microelectronics processes enabled by the proposed device can result in remarkable developments in highly integrated photonic platforms utilizing chiroptical responses.
Raman and fluorescence characteristics of resonant inelastic X-ray scattering from doped superconducting cuprates
Authors: Huang H. Y. , Jia C. J. , Chen Z. Y. , Wohlfeld K. , Moritz B. , Devereaux T. P. , Wu W. B. , Okamoto J. , Lee W. S. , Hashimoto M. , He Y. , Shen Z. X. , Yoshida Y. , Eisaki H. , Mou C. Y. , Chen C. T. , Huang D. J. 
Published: January 2016

AbstractMeasurements of spin excitations are essential for an understanding of spin-mediated pairing for superconductivity; and resonant inelastic X-ray scattering (RIXS) provides a considerable opportunity to probe high-energy spin excitations. However, whether RIXS correctly measures the collective spin excitations of doped superconducting cuprates remains under debate. Here we demonstrate distinct Raman- and fluorescence-like RIXS excitations of Bi1.5Pb0.6Sr1.54CaCu2O8+δ. Combining photon-energy and momentum dependent RIXS measurements with theoretical calculations using exact diagonalization provides conclusive evidence that the Raman-like RIXS excitations correspond to collective spin excitations, which are magnons in the undoped Mott insulators and evolve into paramagnons in doped superconducting compounds. In contrast, the fluorescence-like shifts are due primarily to the continuum of particle-hole excitations in the charge channel. Our results show that under the proper experimental conditions RIXS indeed can be used to probe paramagnons in doped high-Tc cuprate superconductors.
Topography induces differential sensitivity on cancer cell proliferation via Rho-ROCK-Myosin contractility
Authors: Chaudhuri Parthiv Kant , Pan Catherine Qiurong , Low Boon Chuan , Lim Chwee Teck 
Published: January 2016

AbstractAlthough the role of stiffness on proliferative response of cancer cells has been well studied, little is known about the effect of topographic cues in guiding cancer cell proliferation. Here, we examined the effect of topographic cues on cancer cell proliferation using micron scale topographic features and observed that anisotropic features like microgratings at specific dimension could reduce proliferation of non-cancer breast epithelial cells (MCF-10A) but not that for malignant breast cancer cells (MDA-MB-231 and MCF-7). However, isotropic features such as micropillars did not affect proliferation of MCF-10A, indicating that the anisotropic environmental cues are essential for this process. Interestingly, acto-myosin contraction inhibitory drugs, Y-27632 and blebbistatin prevented micrograting-mediated inhibition on proliferation. Here, we propose the concept of Mechanically-Induced Dormancy (MID) where topographic cues could activate Rho-ROCK-Myosin signaling to suppress non-cancerous cells proliferation whereas malignant cells are resistant to this inhibitory barrier and therefore continue uncontrolled proliferation.
Obesity is associated with changes in oxysterol metabolism and levels in mice liver, hypothalamus, adipose tissue and plasma
Authors: Guillemot-Legris Owein , Mutemberezi Valentin , Cani Patrice D. , Muccioli Giulio G. 
Published: January 2016

AbstractOxysterols are bioactive lipids derived from cholesterol that are linked to inflammatory processes. Because obesity and metabolic syndrome are characterized by inflammation and altered cholesterol metabolism, we sought to investigate the variations of oxysterol levels and their metabolic pathways induced by obesity in the liver, hypothalamus, adipose tissue and plasma. To this end, we used diet-induced and genetic (ob/ob and db/db) models of obesity. Among the oxysterols measured, we found that 4β-oxysterol levels were consistently decreased in the high-fat diet study, at different time-points and in the ob/ob model. Overall, we did not find any correlation between cytochromes mRNA expression and variations of oxysterol levels. We also measured the levels of hepatic primary bile acids, in these three models and found similar profiles between HFD and ob/ob mice. However, although they are downstream metabolites of oxysterols, the variations in bile acid levels did not reflect the variations of their precursors. Our data show that, when considering oxysterol metabolism, the high-fat diet and ob/ob models are more closely related when compared to the db/db model. However, we were able to discriminate between lean and obese phenotypes based on liver oxysterol (4β-hydroxycholesterol, 27- hydroxycholesterol, 7-hydroxycholestenone) levels and enzyme (CYP3A11, CYP27A1, CYP7A1) expression.
QTL analysis of modifiers for pigmentary disorder in rats carrying Ednrbsl mutations
Authors: Huang Jieping , Dang Ruihua , Torigoe Daisuke , Li Anqi , Lei Chuzhao , Sasaki Nobuya , Wang Jinxi , Agui Takashi 
Published: January 2016

AbstractPigmentary variation in animals has been studied because of its application in genetics, evolution and developmental biology. The large number of known color loci provides rich resource to elucidate the functional pigmentary system. Nonetheless, more color loci remain to be identified. In our previous study, we revealed that two different strains, namely, AGH rats and LEH rats, but which had the same null mutation of the Ednrb gene (Ednrbsl) showed markedly different pigmented coat ratio. This result strongly suggested that the severity of pigment abnormality was modified by genetic factor(s) in each strain. To elucidate the modifier locus of pigment disorder, we carried out whole-genome scanning for quantitative trait loci (QTLs) on 149 F2 (AGH-Ednrbsl × LEH-Ednrbsl) rats. A highly significant QTL, constituting 26% of the total pigmentation phenotype variance, was identified in a region around D7Got23 on chromosome (Chr) 7. In addition, investigation on epistatic interaction revealed significant interactions between D7Got23 and D3Rat78 and between D7Got23 and D14Mit4. Results suggested that a modified locus on Chr 7 was mainly responsible for the variance of pigmentary disorder between AGH-Ednrbsl rats and LEH-Ednrbsl rats and two modifier loci showing epistatic interaction may, in part, influence pigment phenotype.