bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chesapeake Bay fish–osprey (Pandion haliaetus) food chain: Evaluation of contaminant exposure and genetic damage
Authors: Lazarus Rebecca S. , Rattner Barnett A. , McGowan Peter C. , Hale Robert C. , Karouna-Renier Natalie K. , Erickson Richard A. , Ottinger Mary Ann 
Published: January 2016

Abstract

From 2011 to 2013, a large-scale ecotoxicological study was conducted in several Chesapeake Bay (USA) tributaries (Susquehanna River and flats, the Back, Baltimore Harbor/Patapsco Rivers, Anacostia/ middle Potomac, Elizabeth and James Rivers) and Poplar Island as a mid-Bay reference site. Osprey (Pandion haliaetus) diet and the transfer of contaminants from fish to osprey eggs were evaluated. The most bioaccumulative compounds (biomagnification factor &gt; 5) included p,p′-dichlorodiphenyldichloroethylene (DDE), total polychlorinated biphenyls (PCBs), total polybrominated diphenyl ethers (PBDEs), and bromodiphenyl ether (BDE) congeners 47, 99, 100, and 154. This analysis suggested that alternative brominated flame retardants and other compounds (methoxytriclosan) are not appreciably biomagnifying. A multivariate analysis of similarity indicated that major differences in patterns among study sites were driven by PCB congeners 105, 128, 156, 170/190, and 189, and PBDE congeners 99 and 209. An integrative redundancy analysis showed that osprey eggs from Baltimore Harbor/Patapsco River and the Elizabeth River had high residues of PCBs and p,p′-DDE, with PBDEs making a substantial contribution to overall halogenated contamination on the Susquehanna and Anacostia/middle Potomac Rivers. The redundancy analysis also suggested a potential relation between PBDE residues in osprey eggs and oxidative DNA damage in nestling blood samples. The results also indicate that there is no longer a discernible relation between halogenated contaminants in osprey eggs and their reproductive success in Chesapeake Bay. Osprey populations are thriving in much of the Chesapeake, with productivity rates exceeding those required to sustain a stable population. Environ Toxicol Chem 2016;35:1560–1575. Published 2016 Wiley Periodicals Inc. on behalf of SETAC. This article is a US Government work and, as such, is in the public domain in the United States of America.
Selection of food combinations to optimize survival, growth, and reproduction of the amphipod Hyalella azteca in static-renewal, water-only laboratory exposures
Authors: Soucek David J. , Dickinson Amy , Major Kaley M. 
Published: January 2016

Abstract

Although standardized sediment toxicity testing methods have been developed for the amphipod Hyalella azteca, no standardized chronic water-only toxicity testing methods have been established. Furthermore, optimal feeding and water quality conditions for culturing and toxicity testing with this species remained unclear. The objective of the present study was to determine the food or combination of foods that best promotes survival, growth, and reproduction of the US Lab strain of Hyalella azteca under 42-d, water-only, static-renewal testing conditions. The authors conducted 7 42-d control (no toxicant) tests with various combinations of food (including Tetramin, yeast–cereal leaves–trout chow, diatoms, wheatgrass, alfalfa, and maple leaves) and substrate types (clean “unconditioned” Nitex screens vs “conditioned” Nitex screens that were colonized by live biofilms). Over all treatments, survival ranged from 18% to 96%, dry weight per individual from 0.084 mg to 1.101 mg, and reproduction from 0 young/female to 28.4 young/female. Treatments that included Tetramin tended to result in better performance than those that did not. In particular, treatments that included Tetramin and either conditioned screens or diatoms consistently had high survival, weight, and reproduction values as well as low variability among replicates (measured as coefficient of variation). A ramped Tetramin plus diatom suspension feeding regime appears to have the greatest potential to produce consistently good performance across laboratories using static-renewal systems. Environ Toxicol Chem 2016;35:2407–2415. © 2016 SETAC
Assessing the toxicity of sediments using the medaka embryo–larval assay and 2 other bioassays
Authors: Barhoumi Badreddine , Clérandeau Christelle , Landi Laure , Pichon Anaïk , Le Bihanic Florane , Poirier Dominique , Anschutz Pierre , Budzinski Hélène , Driss Mohamed Ridha , Cachot Jérôme 
Published: January 2016

Abstract

Sediments are sinks for aquatic pollutants, and analyzing toxicity in such complex matrices is still challenging. To evaluate the toxicity of bioavailable pollutants accumulated in sediments from the Bizerte lagoon (Tunisia), a novel assay, the medaka embryo–larval assay by sediment contact, was applied. Japanese medaka (Oryzias latipes) embryos were incubated in direct contact with sediment samples up to hatching. Lethal and sublethal adverse effects were recorded in embryos and larvae up to 20 d postfertilization. Results from medaka embryo–larval assay were compared with cytotoxicity (Microtox®), genotoxicity (SOS chromotest), and pollutant content of sediments. The results highlight differences in the contamination profile and toxicity pattern between the different studied sediments. A significant correlation was shown between medaka embryo–larval assay by sediment contact and SOS chromotest responses and concentrations of most organic pollutants studied. No correlation was shown between pollutant levels and Microtox. According to the number of sediment samples detected as toxic, medaka embryo–larval assay by sediment contact was more sensitive than Microtox, which in turn was more sensitive than the SOS chromotest; and medaka embryo–larval assay by sediment contact allowed sediment toxicity assessment of moderately polluted sediments without pollutant extraction and using an ecologically realistic exposure scenario. Although medaka embryo–larval assay by sediment contact should be tested on a larger sample set, the results show that it is sensitive and convenient enough to monitor the toxicity of natural sediments. Environ Toxicol Chem 2016;35:2270–2280. © 2016 SETAC
Intrinsic functional connectivity of periaqueductal gray subregions in humans
Authors: Coulombe Marie‐Andree , Erpelding Nathalie , Kucyi Aaron , Davis Karen Deborah 
Published: January 2016

AbstractThe periaqueductal gray matter (PAG) is a key brain region of the descending pain modulation pathway. It is also involved in cardiovascular functions, anxiety, and fear; however, little is known about PAG subdivisions in humans. The aims of this study were to use resting‐state fMRI‐based functional connectivity (FC) to parcellate the human PAG and to determine FC of its subregions. To do this, we acquired resting‐state fMRI scans from 79 healthy subjects and (1) used a data‐driven method to parcellate the PAG, (2) used predefined seeds in PAG subregions to evaluate PAG FC to the whole brain, and (3) examined sex differences in PAG FC. We found that clustering of the left and right PAG yielded similar patterns of caudal, middle, and rostral subdivisions in the coronal plane, and dorsal and ventral subdivisions in the sagittal plane. FC analysis of predefined subregions revealed that the ventolateral(VL)‐PAG was supfunctionally connected to brain regions associated with descending pain modulation (anterior cingulate cortex (ACC), upper pons/medulla), whereas the lateral (L) and dorsolateral (DL) subregions were connected with brain regions implicated in executive functions (prefrontal cortex, striatum, hippocampus). We also found sex differences in FC including areas implicated in pain, salience, and analgesia including the ACC and the insula in women, and the MCC, parahippocampal gyrus, and the temporal pole in men. The organization of the human PAG thus provides a framework to understand the circuitry underlying the broad range of responses to pain and its modulation in men and women. Hum Brain Mapp 37:1514‐1530, 2016. © 2016 Wiley Periodicals, Inc.
Comparative Analysis of the Informal Pre‐Insolvency Procedures of the UK and France
Authors: Kastrinou Alexandra 
Published: January 2016

AbstractThe aim of this paper is to provide a brief overview of the informal pre‐insolvency proceedings available in the UK and France. In addition, the aim is to provide a comparative analysis of the approach taken towards corporate rescue at this early stage by the ‘key players’ in insolvency. In particular, emphasis will be placed on the role of insolvency practitioners and creditors as well as the involvement of the courts in pre‐insolvency restructurings. Finally, the paper considers the effectiveness of the pre‐insolvency mechanisms available in the two jurisdictions and assesses whether or not these promote and encourage a corporate rescue culture. Copyright © 2016 INSOL International and John Wiley & Sons, Ltd. Copyright © 2016 INSOL International and John Wiley & Sons, Ltd
Enhancement of local bone remodeling in osteoporotic rabbits by biomimic multilayered structures on Ti6Al4V implants
Authors: Huang Ling , Luo Zhong , Hu Yan , Shen Xinkun , Li Menghuan , Li Liqi , Zhang Yuan , Yang Weihu , Liu Peng , Cai Kaiyong 
Published: January 2016

AbstractTo enhance long‐term survival of titanium implants in patients with osteoporosis, chitosan/gelatin multilayers containing bone morphogenetic protein 2(BMP2) and an antiosteoporotic agent of calcitonin (CT) are deposited on the Ti6Al4V (TC4) implants through layer‐by‐layer (LBL) electrostatic assembly technique. Here, the obtained titanium alloy implant (TC4/LBL/CT/BMP2) can regulate the release of loaded calcitonin and BMP2 agents in a sustaining manner to accelerate the bone formation and simultaneously inhibit bone resorption. In vitro results show that the bone‐related cells on TC4/LBL/CT/BMP2 present the lowest production level of tartrate resistant acid phosphatase (TRAP) but the highest (p < 0.05) level of alkaline phosphatase (ALP) activity, osteocalcin production, mineralization capacity and osteoblast‐related gene expression among all groups after treatment for 7 or 21 days, respectively. Besides, in vivo studies of micro‐CT analysis, routine histological and immunohistochemical analysis also collectively demonstrate that the TC4/LBL/CT/BMP2 implant can dramatically promote the formation and remodeling of new bone in osteoporotic rabbits after implantation for 30 days and 90 days, respectively. In vivo push‐out testing further confirms that the TC4/LBL/CT/BMP2 implant has the highest (p < 0.01) interfacial shear strength and favorable bone‐implant osseointegration. Overall, this study establishes a simple and profound methodology to fabricate a biofunctional TC4 implant for the treatment of local osteoporotic fractures in vivo. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 1437–1451, 2016.
Real‐time quantitation of internal metabolic activity of three‐dimensional engineered tissues using an oxygen microelectrode and optical coherence tomography
Authors: Kagawa Yuki , Haraguchi Yuji , Tsuneda Satoshi , Shimizu Tatsuya 
Published: January 2016

AbstractRecent progress in tissue engineering technology has enabled us to develop thick tissue constructs that can then be transplanted in regenerative therapies. In clinical situations, it is vital that the engineered tissues to be implanted are safe and functional before use. However, there is currently a limited number of studies on real‐time quality evaluation of thick living tissue constructs. Here we developed a system for quantifying the internal activities of engineered tissues, from which we can evaluate its quality in real‐time. The evaluation was achieved by measuring oxygen concentration profiles made along the vertical axis and the thickness of the tissues estimated from cross‐sectional images obtained noninvasively by an optical coherence tomography system. Using our novel system, we obtained (i) oxygen concentration just above the tissues, (ii) gradient of oxygen along vertical axis formed above the tissues within culture medium, and (iii) gradient of oxygen formed within the tissues in real‐time. Investigating whether these three parameters could be used to evaluate engineered tissues during culturing, we found that only the third parameter was a good candidate. This implies that the activity of living engineered tissues can be monitored in real‐time by measuring the oxygen gradient within the tissues. The proposed measuring strategy can be applied to developing more efficient culturing methods to support the fabrication of engineered thick tissues, as well as providing methods to confirm the quality in real‐time. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 855–864, 2017.
Pre‐ultrafiltration or pre‐ozonation for EDCs removal in a combined ultrafiltration and ozonation process
Authors: Hu Zunfang , Wen Xianghua , Si Xiurong 
Published: January 2016

AbstractBACKGROUNDUltrafiltration (UF) coupled with ozonation (O3) may be a promising process for removing endocrine disrupting chemicals (EDCs) from secondary effluent. One key point in employing this process is whether the UF unit should be set in front of or after the O3 unit. So, in this paper, two systems with reversing series of UF and O3 units were developed and operated to assess which one is better.RESULTSResults showed that the O3‐UF process exhibited 13% higher UV adsorption removal efficiency than the UF‐O3 process. EDCs concentration and estrogenicity removal efficiency of the O3‐UF process was 2–7% and 10%, respectively, greater than that of the UF‐O3 process. In addition, the O3‐UF process achieved higher membrane filtration flux (28.9 LMH) than that (25.6 LMH) of the UF‐O3 process. A pilot scale O3‐UF reactor was designed to treat a real secondary effluent and achieved effective EDCs removal (average 75.2%) and estrogenicity removal (average 84.3%).CONCLUSIONSThis study indicated that the O3‐UF process can effectively remove EDCs from secondary effluent and produced weaker membrane fouling than the UF‐O3 process; therefore, it was suggested for treating EDCs‐containing secondary effluent. © 2016 Society of Chemical Industry
Urban wastewater treatment plant provided with tertiary finishing lagoons: management and reclamation for irrigation reuse
Authors: Fiorentino Carmine , Mancini Maurizio , Luccarini Luca 
Published: January 2016

AbstractBACKGROUNDIn recent years water scarcity has become more prominent, increasing the need for new practices in terms of efficient water management. Reuse and valorization of water from wastewater treatment plants (WWTPs) can help solve the problem.RESULTSThe traditional denitrification/nitrification scheme followed by a natural disinfection/storage tank has been studied in order to optimize the process for irrigation reuse. The study is based on data produced by an experimental pilot‐scale plant, located in Trebbo di Reno (BO, Italy) and from a recent field campaign carried out on internal fresh water of the Allacciamento Channel inside the basin of Porto Canale Cesenatico (FC, Italy). Using WEST software to model the first phase and a dispersed flow equation to model the Escherichia coli (E. coli) removal rate in the following basin, the overall process has been optimized to test the capacity of a Business Process Management (BPM) approach to model the water storage management for irrigation reuse.CONCLUSIONSHigh pollutants removal efficiencies and a water storage system able to fulfill the irrigation needs are two essential requirements for water reuse. The study shows how to achieve those aims using a combined system with a natural disinfection basin analyzing the hydraulic parameters effects on pollutants removal throughout the water column. Moreover, the management optimization of the process has been studied suggesting different management policies for different scenarios. © 2016 Society of Chemical Industry
New digital cholangiopancreatoscopy for diagnosis and therapy of pancreaticobiliary diseases (with videos)
Authors: Tanaka Reina , Itoi Takao , Honjo Mitsusyoshi , Tsuchiya Takayoshi , Kurihara Toshio , Tsuji Shujiro , Tonozuka Ryosuke , Kamada Kentato , Sofuni Atsushi , Mukai Shuntaro 
Published: January 2016

AbstractBackgroundRecently, a new digital cholangiopancreatoscopy (DCPS) has been developed. The aim of this study is to retrospectively evaluate the utility of new DCPS in patients with pancreaticobiliary diseases.MethodsDigital cholangiopancreatoscopy was used in 26 patients (16 men) with pancreaticobiliary diseases that could not be diagnosed and treated by standard endoscopic retrograde cholangiopancreatography (ERCP). The procedures included DCPS‐guided tissue sampling and interventions. Technical success and adverse events were evaluated.ResultsAmong the 26 patients, 19 patients were classified for diagnostic purposes and seven for therapeutic purposes. The detailed breakdown of the particular conditions and numbers of patients was as follows: indeterminate bile duct (BD) lesion, indeterminate pancreatic duct (PD) lesion, lithotripsy by yttrium aluminum garnet‐laser or electrohydraulic lithotripsy, removal of migrated BD stent and PD stent, and guidewire passing across the biliary stricture. The overall technical success rates of visualizing the target lesions and therapeutic interventions were 100% and 85.7%, respectively. The incidence of procedure‐related adverse events among the patients was 7.7% (2/26). Cholangitis developed in one of the patients and post‐endoscopic sphincterotomy bleeding in one patient. All adverse events were successfully treated by conservative therapy.ConclusionDigital cholangiopancreatoscopy has a high potential for providing an accurate diagnosis and facilitating therapy in patients with pancreaticobiliary diseases.
Transcribing the First Decade of Children's Videotaped Testimonies in Cyprus: Tourist Season Times
Authors: Kyriakidou Marilena , Zalaf Alexia 
Published: January 2016

AbstractFamiliarising researchers and practitioners with different countries' policies for police interviews with children contributes to an exchange of knowledge and strengthens global approaches against child abuse. We start by describing the system of videotaped testimonies in Cyprus during the first 10 years of this system's implementation. We then continue on to the effects of tourism on police interviews with children. Police forces in destinations with high tourist numbers need to comprehend how tourist seasons could influence police interviews with children. No studies investigated whether children of tourists testified in police departments during their holidays. We explored how tourist seasons affected the number of testimonies obtained by Cyprus police forces, taking into account the presence of non‐Cypriot and non‐native speaking children, the number of testimonies taken in languages other than Greek, and the presence of translators during the interviews. We analysed the national sample of police interviews with children for a period of a decade using official police records and copies of transcripts of children's testimonies. As expected, the results revealed no significant differences in police interviews with children during tourist seasons but show a slight increase in the number of interviews with non‐Cypriot children during tourist seasons. Copyright © 2016 John Wiley & Sons, Ltd.
Friction and wear reductions in fluorinated plain and fully formulated oils through enhanced heating time using moderate loading under boundary lubrication conditions
Authors: Nehme Gabi N. 
Published: January 2016

AbstractThe use of fluorinated mix catalyst (titanium fluoride: TiF3 + iron fluoride: FeF3) with polytetrafluoroethylene: PTFE in engine oil is increasingly a strategy to improve fuel economy and component durability to simultaneously provide low friction and excellent wear protection. The influence of these additives shows promising results during load bearing capacity testing and long‐term durability experiments. This paper addresses the enhancement of friction and wear performances of 0.1% and 0.05% phosphorus plain zinc dialkyl dithiophosphate (ZDDP) oil and fully formulated engine oil when heated to 100°C for specific time under thermal and tribological conditions for moderate pressure loading (1.9 GPa Hertzian pressure or 180 N) which simulate the cold start of a car under 700 rpm rotational speed or the valve trains loading where most of the ZDDP are applied.Tests were performed in a ball on cylinder tribometer under boundary lubrication conditions. Surface analyses were carried out using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Results showed that the anti‐wear additives (2 wt. % PTFE + 0.5 wt. % FeF3 + .5 wt. % TiF3) provided excellent wear protection to 0.1% phosphorus plain and fully formulated oil when cylinder is immersed in the desired lubricant and heated for a predetermined time but performed poorly in 0.05% phosphorus fully formulated oil under the same conditions. The transform of anti‐wear coated material to the worn surfaces, which was a function of the anti‐wear performance of additives, was shown to have an influence on friction performance. The wear reducing effect, which was observed in fluorinated additives tribological tests, indicated a positive contribution and good tribofilm formations. Copyright © 2016 John Wiley & Sons, Ltd.
Acid Sensitive Polymeric Micelles Combining Folate and Bioreducible Conjugate for Specific Intracellular siRNA Delivery
Authors: Yang Yanfang , Xia Xuejun , Dong Wujun , Wang Hongliang , Li Lin , Ma Panpan , Sheng Wei , Xu Xueqing , Liu Yuling 
Published: January 2016

An efficiently siRNA transporting nanocarrier still remains to be developed. In this study, utilizing the dual stimulus of acid tumor extracellular environment and redox effect of glutathione in the cytosol, a new siRNA transporting system combining triple effects of folate targeting, acid sensitive polymer micelles, and bio‐reducible disulfide bond linked siRNA‐cell penetrating peptides (CPPs) conjugate is developed to suppress c‐myc gene expression of breast cancer (MCF‐7 cells) both in vitro and in vivo. Subsequent research demonstrates that the vesicle has particle size of about 100 nm and siRNA entrapment efficiency of approximately 80%. In vitro studies verified over 90% of encapsulated siRNA‐CPPs can be released and the vesicle shows higher cellular uptake in response to the tumorous zone. Determination of gene expression at both mRNA and protein levels indicates the constructed vesicle exhibited enhanced cancer cell apoptosis and improved therapeutic efficacy in vitro and in vivo.
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On short‐range enhancement of Van‐der‐Waals forces
Authors: Makhnovets K. , Kolezhuk A. 
Published: January 2016

For nanoparticles with giant polarizability α (a prominent example being the recently studied Na14F13 molecular clusters) van der Waals forces are significantly enhanced at interparticle distances shorter than R0 ≃ (α/2πε0)1/3. For an adequate description of this phenomenon, nonlinear effects must be taken into account. Contrary to some theoretical claims, an accurate treatment of nonlinearity does not lead to any repulsive forces.
Focal Predominant Forms of Posthypoxic Action Myoclonus
Authors: Gasca‐Salas Carmen , Lang Anthony E. 
Published: January 2016

AbstractChronic posthypoxic action myoclonus is usually recognized as multifocal or generalized and, in most cases, causes severe disability. It is also commonly associated with other neurological symptoms, such as ataxia. We report two cases of focal predominant postanoxic action myoclonus and review the limited relevant literature. The first case presented with action and stimulus sensitive myoclonus in the lower limbs that caused him limited disability. He had not received any diagnosis in almost 2 years. The second patient exhibited predominantly focal facial myoclonus, although she was more limited by dysphasia and hemiplegia as a consequence of an ischemic stroke. Both patients responded to antiepileptic drugs. We found 9 of 159 previously reported cases with this focal distribution. Physicians should be aware of this limited phenotype given that the unusual focal nature of the movements may result in incorrect diagnosis and treatment.