bluuebunny/crossref_metadata_2025_split huggingface dataset:
Flagellate Dermatitis in a Child Most Likely Secondary to Doxorubicin
Authors: Lim Darosa , Aussedat Marine , Maillet‐Lebel Nicole , Marcoux Danielle 
Published: August 2017

AbstractFlagellate dermatitis, a cutaneous eruption in which the patient appears to have been whipped, has been described with antineoplastic agents and shiitake mushroom ingestion. A 15‐year‐old girl with metastatic Ewing sarcoma developed pruritic erythematous linear lesions on her trunk that became hyperpigmented over time during her first cycle of chemotherapy with doxorubicin, vincristine, cyclophosphamide, and ganitumab. Flagellate dermatitis was diagnosed based on clinical and histologic findings. Flagellate dermatitis (FD) is a rare cutaneous eruption named for its appearance, in which the patient appears to have been whipped. It has been associated with chemotherapeutic agents such as bleomycin . We report FD in a child that occurred during chemotherapy treatment that included doxorubicin.
Birthweight and serum uric acid in American adolescents
Authors: Rhone Erika T. , Carmody J. Bryan 
Published: August 2017

AbstractElevated serum uric acid is associated with hypertension and chronic kidney disease. We evaluated the relationship between birthweight and uric acid in a nationally representative sample of 5390 US adolescents aged 12–15 in the National Health and Nutrition Examination Survey from 1999 to 2012. There was an inverse association between birthweight and uric acid after adjustment for sex, age, race, obesity, and dietary sodium intake. Each 1 kg increase in birthweight was associated with decreased uric acid by 0.11 mg/dL (95% CI: −0.16 to −0.06; model R2 = 0.32). This relationship was stronger in adolescents with elevated blood pressure (β = –0.25; 95% CI: −0.44 to −0.06; R2 = 0.50) but persisted in adolescents with normal blood pressure (β = –0.10; 95% CI: −0.15 to −0.05; R2 = 0.31). In conclusion, lower birthweight is associated with higher uric acid in US adolescents. These findings may support the hypothesis that reduced nephron number is associated with elevated uric acid.
Comparative proteomic analysis of different developmental stages of swamp buffalo testicular seminiferous tubules
Authors: Zhang P‐F , Huang Y‐L , Fu Q , Chen F‐M , Lu Y‐Q , Liang X‐W , Zhang M 
Published: August 2017

ContentsWith ageing, many protein components change markedly during mammalian spermatogenesis. Most of these proteins have yet to be characterized and verified. Here, we have employed two‐dimensional electrophoresis coupled to tandem mass spectrometry to explore the different proteins from pre‐pubertal, pubertal and post‐pubertal swamp buffalo testicular seminiferous tubules. The results showed that 25 protein spots were differentially expressed among developmental stages, and 13 of them were successfully identified by mass spectrometry. Of which four proteins were up‐regulated and three proteins were down‐regulated with age, and the remaining six proteins were fluctuated among developmental stages. Bioinformatics analysis indicates that these proteins were probably related to cellular developmental process (53.8%), cell differentiation (53.8%), spermatogenesis (15.4%), apoptotic process and cell death (30.8%). Expression profiles of calumenin (CALU) and galectin‐1 (LGALS1) were further verified via Western blotting. In summary, the results help to develop an understanding of molecular mechanisms associated with buffalo spermatogenesis.
Effect of housing system on reproductive behaviour and on some endocrinological and seminal parameters of donkey stallions
Authors: Rota A , Sgorbini M , Panzani D , Bonelli F , Baragli P , Ille N , Gatta D , Sighieri C , Casini L , Maggiorelli MM , Aurich C , Camillo F 
Published: August 2017

ContentsReproductive management of male donkeys employed for artificial breeding has been poorly studied. The aim of this study was to evaluate the effect of housing system, with the animals grouped together in a paddock or kept in individual boxes, on sexual behaviour, cortisol and testosterone concentration and seminal characteristics of adult male donkeys. The study included four Amiata donkey jacks (stallions) from which ejaculates, saliva and blood were collected during two distinct 3 weeks periods, one in the group and one in the box housing system. Time needed for semen collection was shorter when donkeys were kept in paddocks compared to when they were kept in single boxes (14:57 ± 07:27 and 20:52 ± 09:31 min, p < .05). Native semen characteristics were not influenced by housing system, while cooled preservation in an Equitainer® showed that sperm motility parameters were significantly higher during the paddock period compared to the box period. Salivary cortisol was influenced by housing system, both before and 60 min after ejaculation, being statistically higher when donkeys were housed in paddocks. On the contrary, overall and basal testosterone concentrations were significantly higher when animals were kept in boxes. In conclusion, in the present study, good quality semen could be successfully collected from donkeys irrespective of the housing system despite some differences in hormone concentrations.
Biochemical analysis of uterine fluid for identification of indicators for subclinical endometritis in the water buffalo (Bubalus bubalis)
Authors: Gahlot SC , Kumar S , Kumaresan A , Vairamuthu S , Saraf KK , Sreela L , Baithalu RK , Lathwal SS , Mohanty TK 
Published: August 2017

ContentsAlterations in biochemical constituents of uterine fluid have been suggested for diagnosis of subclinical uterine infection in the bovine. This study was undertaken to investigate whether uterine fluid biomolecules could act as tool for diagnosis of subclinical endometritis in the buffalo. Uterine fluid samples from normal (n = 22) and subclinical endometritis (n = 18; diagnosed based on uterine cytology)‐affected buffaloes were subjected to biochemical analysis. Among the different biochemical constituents estimated, urea, urea N, cholesterol, total bilirubin and alkaline phosphatase (ALP) concentrations were significantly (p < 0.05) higher in uterine fluid obtained from subclinical endometritis‐affected buffaloes. The extent of difference between normal and subclinical endometritis‐affected buffaloes was highest in ALP (69%) followed by cholesterol (55%), bilirubin (48%), urea (30%) and urea N (30%) concentrations. Receiver operating characteristic (ROC) analysis indicated that the likelihood ratio (LR) was 3.63 for urea, indicating that buffaloes having less than the threshold concentration (47.5 mg/dl) of urea in their uterine fluid were at 3.6 times more risk to be affected with SE. The LRs for urea N, cholesterol, ALP and bilirubin were 2.33, 2.54, 2.12 and 1.65, respectively. It was concluded that ALP, urea, urea N and cholesterol concentrations in uterine fluid may serve as an aid for diagnosing subclinical endometritis in the buffalo.
Using Internet Search Data to Measure Changes in Social Perceptions: A Methodology and an Application*
Authors: Reyes Tomas , Majluf Nicolás , Ibáñez Ricardo 
Published: August 2017

ObjectivesSocial perceptions in areas such as family life, economy, education, health, and energy can be uncertain and difficult to measure. This article proposes a well‐defined methodology to measure social perceptions by observing individuals’ Google searches for online content with the support of three free tools: Google Trends, Keyword Planner, and Related Searches.MethodsThe proposed methodology is a step‐by‐step process that identifies representative keywords for prevailing social perceptions, and then aggregates them into specialized descriptive indexes, which are designed to highlight changes in search trends over time.ResultsTo exemplify the process, the methodology is applied to measure changes in economic and social perceptions in Chile during 2004–2014. Results show that, over these years, Chileans moved from a pro‐business view to a largely anti‐business perspective based on issues such as lucre, inequality, and abuses.ConclusionsThe methodology works well, as we are able to identify in two complementary ways the moment at which Chilean citizens moved from one perspective to another. The application of this methodology to Mexico, Peru, and Colombia also provided satisfactory results.
GEN_MAT: A MATLAB‐based map generalization algorithm toolbox
Authors: Wang Yiheng , Tian Jing , Yu Mengting , Ren Chang , Wu Xiaohuan 
Published: August 2017

AbstractAssistive tools are important for improving teaching and learning quality in courses that involve practical work. This article presents an overview of GEN_MAT, the first MATLAB‐based map generalization algorithm toolbox. The toolbox provides 42 map generalization algorithms for aggregation, selective omission, simplification, smoothing, collapse, agglomeration, merging, dissolving, displacement, and typification. A beta test of the application of GEN_MAT in teaching and learning was conducted. Evaluations showed that GEN_MAT has positive effects on teaching and learning. Comparing tool‐based and non‐tool‐based courses indicated that the experimental group performed better than the control group, and the two groups exhibited significant discrepancy (p < 0.05) in confidence, awareness, skills and attitudes or behaviors.
Absence of JC polyomavirus (JCPyV) viremia in early post‐transplant JCPyV nephropathy: A case report
Authors: Janphram Chitimaporn , Worawichawong Suchin , Disthabanchong Sinee , Sumethkul Vasant , Rotjanapan Porpon 
Published: August 2017

AbstractJC polyomavirus (JCPyV)‐associated nephropathy (JCPyVAN) occurs in <3% of PVAN cases after renal transplantation. We report the first confirmed case to our knowledge of JCPyVAN diagnosed by kidney biopsy in the early 6 months post transplant in Thailand. In this case report, recovery of renal allograft function was not observed after reduction of immunosuppressive agents and administration of intravenous immunoglobulin and cidofovir. Despite persistent JCPyV viruria, no significant further decline in allograft function was documented at 15 months post transplant.
Correlation of 6‐min walk test with left ventricular function and quality of life in heart failure due to Chagas disease
Authors: Chambela Mayara C. , Mediano Mauro F. F. , Ferreira Roberto R. , Japiassú André M. , Waghabi Mariana C. , da Silva Gilberto M. S. , Saraiva Roberto M. 
Published: August 2017

AbstractObjectivesTo evaluate the correlation of the total distance walked during the six‐minute walk test (6MWT) with left ventricular function and quality of life in patients with Chagas Disease (ChD) complicated by heart failure.MethodsThis is a cross‐sectional study of adult patients with ChD and heart failure diagnosed based on Framingham criteria. 6MWT was performed following international guidelines. New York Heart Association functional class, brain natriuretic peptide (BNP) serum levels, echocardiographic parameters and quality of life (SF‐36 and MLHFQ questionnaires) were determined and their correlation with the distance covered at the 6MWT was tested.ResultsForty adult patients (19 male; 60 ± 12 years old) with ChD and heart failure were included in this study. The mean left ventricular ejection fraction was 35 ± 12%. Only two patients (5%) ceased walking before 6 min had elapsed. There were no cardiac events during the test. The average distance covered was 337 ± 105 metres. The distance covered presented a negative correlation with BNP (r = −0.37; P = 0.02), MLHFQ quality‐of‐life score (r = −0.54; P = 0.002), pulmonary artery systolic pressure (r = −0.42; P = 0.02) and the degree of diastolic dysfunction (r = −0.36; P = 0.03) and mitral regurgitation (r = −0.53; P = 0.0006) and positive correlation with several domains of the SF‐36 questionnaire.ConclusionsThe distance walked during the 6MWT correlates with BNP, quality of life and parameters of left ventricular diastolic function in ChD patients with heart failure. We propose this test to be adopted in endemic areas with limited resources to aid in the identification of patients who need referral for tertiary centres for further evaluation and treatment.
PALE CRESS binds to plastid RNAs and facilitates the biogenesis of the 50S ribosomal subunit
Authors: Meurer Jörg , Schmid Lisa‐Marie , Stoppel Rhea , Leister Dario , Brachmann Andreas , Manavski Nikolay 
Published: August 2017

SummaryThe plant‐specific PALE CRESS (PAC) protein has previously been shown to be essential for photoautotrophic growth. Here we further investigated the molecular function of the PAC protein. PAC localizes to plastid nucleoids and forms large proteinaceous and RNA‐containing megadalton complexes. It co‐immunoprecipitates with a specific subset of chloroplast RNAs including psbK–psbI, ndhF, ndhD, and 23S ribosomal RNA (rRNA), as demonstrated by RNA immunoprecipitation in combination with high throughput RNA sequencing (RIP‐seq) analyses. Furthermore, it co‐migrates with premature 50S ribosomal particles and specifically binds to 23S rRNA in vitro. This coincides with severely reduced levels of 23S rRNA in pac leading to translational deficiencies and related alterations of plastid transcript patterns and abundance similar to plants treated with the translation inhibitor lincomycin. Thus, we conclude that deficiency in plastid ribosomes accounts for the pac phenotype. Moreover, the absence or reduction of PAC levels in the corresponding mutants induces structural changes of the 23S rRNA, as demonstrated by in vivo RNA structure probing. Our results indicate that PAC binds to the 23S rRNA to promote the biogenesis of the 50S subunit.
Intellectual returnees as drivers of indigenous innovation: Evidence from the Chinese photovoltaic industry
Authors: Luo Siping , Lovely Mary E. , Popp David 
Published: August 2017

AbstractWe offer new evidence on indigenous innovation and intellectual returnees by estimating the relationship between patenting activity by Chinese photovoltaic firms and the presence of corporate leaders with international experience. Our research approach combines data from three sources: the industrial census, international and domestic patent records, and leadership biographical information. Using non‐linear methods, we find robust evidence that returnees positively influence patenting activity and promote neighbouring firm innovation. Our analysis suggests that market liberalisation and industry policy influence patent application counts. Controlling for R&D expenditures, we find that firms with returnees in leadership roles do more patenting.
Evaluation of gastric and bladder tonometry as indicators of tissue perfusion in induced hypotension in dogs
Authors: Morgaz Juan , Espigares‐Rodríguez Lidia , Muñoz‐Rascón Pilar , Navarrete Rocío , Fernández‐Sarmiento Jose Andrés , Granados Machuca María del Mar 
Published: August 2017

AbstractObjectiveTo evaluate the use of gastric (PgCO2) and bladder (PbCO2) tonometry for assessing tissue hypoperfusion in dogs during sevoflurane‐induced hypotension, and to compare these measurements with delivery of oxygen, arterial oxygen content, and plasma lactate concentration.DesignProspective experimental trial.SettingUniversity veterinary teaching hospital.AnimalsFourteen adult Beagle dogs.InterventionsAnesthetic induction was performed by mask with sevoflurane and oxygen. Heart rate, direct arterial pressures, respiratory rate, and end‐tidal carbon dioxide were recorded; arterial blood samples were taken to measure blood gases, and venous samples were sampled to measure plasma lactate. A tonometric catheter was introduced into the stomach to measure PgCO2. Samples of saline from the balloon of a Foley catheter placed in the bladder were collected every 10 minutes and used to measure PbCO2 by gas analysis. Tonometry measurements, plasma lactate, and oxygen delivery and consumption were compared at 3 time points: at baseline, during hypotension, and during treatment periods. A hypotensive period (mean arterial pressure (MAP) < 60 mm Hg) of 15 minutes was induced by an overdose of sevoflurane, whereas during the treatment period, a constant‐rate infusion of dopamine (10 μg/kg/min) was administered intravenously for 40 minutes.Measurements and Main ResultsValues for PgCO2 and PbCO2 increased significantly during the hypotensive period, and correlations were found between these values and the delivery of oxygen. Gastric tonometry values had stronger correlations compared with bladder tonometry values.ConclusionsGastric and bladder tonometry can be used to detect hypoperfusion. Further studies are warranted to determine the potential use of gastric and bladder tonometry in assessing dogs in clinical situations.
Walter Greiner: In Memoriam
Authors: Zen Vasconcellos César , Coelho Helio T. , Hess Peter Otto 
Published: August 2017

Walter Greiner (29 October 1935 - 6 October 2016) was a German theoretical physicist. His scientific research interests include the thematic areas of atomic physics, heavy ion physics, nuclear physics, elementary particle physics (particularly quantum electrodynamics and quantum chromodynamics). He is most known in Germany for his series of books in theoretical physics, but he is also well known around the world. Greiner was born on October 29, 1935, in Neuenbau, Sonnenberg, Germany. He studied physics at the University of Frankfurt (Goethe University in Frankfurt Am Main), receiving in this institution a BSci in physics and a Master’s degree in 1960 with a thesis on plasma-reactors, and a PhD in 1961 at the University of Freiburg under Hans Marshal, with a thesis on the nuclear polarization in [Formula: see text]-mesic atoms. During the period of 1962 to 1964 he was assistant professor at the University of Maryland, followed by a position as research associate at the University of Freiburg, in 1964. Starting in 1965, he became a full professor at the Institute for Theoretical Physics at Goethe University until 2003. Greiner has been a visiting professor to many universities and laboratories, including Florida State University, the University of Virginia, the University of California, the University of Melbourne, Vanderbilt University, Yale University, Oak Ridge National Laboratory and Los Alamos National Laboratory. In 2003, with Wolf Singer, he was the founding Director of the Frankfurt Institute for Advanced Studies (FIAS), and gave lectures and seminars in elementary particle physics. He died on October 6, 2016 at the age of 80. Walter Greiner was an excellent teacher, researcher, friend. And he was a great supporter of the series of events known by the acronyms IWARA - International Workshop on Astronomy and Relativistic Astrophysics, STARS - Caribbean Symposium on Cosmology, Gravitation, Nuclear and Astroparticle Physics, and SMFNS - International Symposium on Strong Electromagnetic Fields and Neutron Stars. Walter Greiner left us. But his memory will remain always alive among us who have had the privilege of knowing him and enjoy his wisdom and joy of living.
On the Parameterized Complexity of Finding Small Unsatisfiable Subsets of CNF Formulas and CSP Instances
Authors: Haan Ronald De , Kanj Iyad , Szeider Stefan 
Published: August 2017

In many practical settings it is useful to find a small unsatisfiable subset of a given unsatisfiable set of constraints. We study this problem from a parameterized complexity perspective, taking the size of the unsatisfiable subset as the natural parameter where the set of constraints is either (i) given a set of clauses, i.e., a formula in conjunctive normal Form (CNF), or (ii) as an instance of the Constraint Satisfaction Problem (CSP).

In general, the problem is fixed-parameter
in
tractable. For an instance of the propositional satisfiability problem (SAT), it was known to be W[1]-complete. We establish A[2]-completeness for CSP instances, where A[2]-hardness prevails already for the Boolean case.

With these fixed-parameter intractability results for the general case in mind, we consider various restricted classes of inputs and draw a detailed complexity landscape. It turns out that often Boolean CSP and CNF formulas behave similarly, but we also identify notable exceptions to this rule.
The main part of this article is dedicated to classes of inputs that are induced by Boolean constraint languages that Schaefer [1978] identified as the maximal constraint languages with a tractable satisfiability problem. We show that for the CSP setting, the problem of finding small unsatisfiable subsets remains fixed-parameter intractable for all Schaefer languages for which the problem is non-trivial. We show that this is also the case for CNF formulas with the exception of the class of bijunctive (Krom) formulas, which allows for an identification of a small unsatisfiable subset in polynomial time.
In addition, we consider various restricted classes of inputs with bounds on the maximum number of times that a variable occurs (the degree), bounds on the arity of constraints, and bounds on the domain size. For the case of CNF formulas, we show that restricting the degree is enough to obtain fixed-parameter tractability, whereas for the case of CSP instances, one needs to restrict the degree, the arity, and the domain size simultaneously to establish fixed-parameter tractability.
Finally, we relate the problem of finding small unsatisfiable subsets of a set of constraints to the problem of identifying whether a given variable-value assignment is entailed or forbidden already by a small subset of constraints. Moreover, we use the connection between the two problems to establish similar parameterized complexity results also for the latter problem.
Caching Online Video
Authors: Akhtar Shahid , Beck Andre , Rimac Ivica 
Published: August 2017

Online video presents new challenges to traditional caching with over a thousand-fold increase in number of assets, rapidly changing popularity of assets and much higher throughput requirements.
We propose a new hierarchical filtering algorithm for caching online video HiFi. Our algorithm is designed to optimize hit rate, replacement rate and cache throughput. It has an associated implementation complexity comparable to that of LRU.
Our results show that, under typical operator conditions, HiFi can increase edge cache byte hit rate by 5%--24% over an LRU policy, but more importantly can increase the RAM or memory byte hit rate by 80% to 200% and reduce the replacement rate by more than 100 times! These two factors combined can dramatically increase throughput for most caches. If SSDs are used for storage, the much lower replacement rate may also allow substitution of lower-cost MLC-based SSDs instead of SLC-based SSDs.
We extend previous multi-tier analytical models for LRU caches to caches with filtering. We analytically show how HiFi can approach the performance of an optimal caching policy and how to tune HiFi to reach as close to optimal performance as the traffic conditions allow. We develop a realistic simulation environment for online video using statistics from operator traces. We show that HiFi performs within a few percentage points from the optimal solution which was simulated by Belady's MIN algorithm under typical operator conditions