bluuebunny/crossref_metadata_2025_split huggingface dataset:
Redes sociais de internet numa escola de ensino médio: entre aprendizagens mútuas e conhecimentos escolares
Authors: Carrano Paulo Cesar Rodrigues 
Published: August 2017

O artigo resulta de estudo de caso em escola pública de Ensino Médio no Rio de Janeiro. No texto, contextualizamos a educação de jovens frente às mudanças societárias. Aplicamos questionário e realizamos entrevistas individuais e em grupos com professores e estudantes. Buscou-se compreender a presença das redes sociais de internet (RSI) no cotidiano escolar. Os dados permitiram ampliar a compreensão sobre as múltiplas interações, convergências e conflitos entre os sujeitos da escola a partir das mediações dessas redes. Encontramos movimentos diferenciados de interação entre professores e estudantes e distintos níveis de habilidades docentes e discentes. Frente às redes sociais, professores expressam práticas que ainda não lograram se constituir numa reconfiguração do Projeto Político Pedagógico da escola investigada.
Decision support for the selection of reference sites using 137Cs as a soil erosion tracer
Authors: Arata Laura , Meusburger Katrin , Bürge Alexandra , Zehringer Markus , Ketterer Michael E. , Mabit Lionel , Alewell Christine 
Published: August 2017

Abstract. The classical approach of using 137Cs as a soil erosion tracer is based on the comparison between stable reference sites and sites affected by soil redistribution processes; it enables the derivation of soil erosion and deposition rates. The method is associated with potentially large sources of uncertainty with major parts of this uncertainty being associated with the selection of the reference sites. We propose a decision support tool to Check the Suitability of reference Sites (CheSS). Commonly, the variation among 137Cs inventories of spatial replicate reference samples is taken as the sole criterion to decide on the suitability of a reference inventory. Here we propose an extension of this procedure using a repeated sampling approach, in which the reference sites are resampled after a certain time period. Suitable reference sites are expected to present no significant temporal variation in their decay-corrected 137Cs depth profiles. Possible causes of variation are assessed by a decision tree. More specifically, the decision tree tests for (i) uncertainty connected to small-scale variability in 137Cs due to its heterogeneous initial fallout (such as in areas affected by the Chernobyl fallout), (ii) signs of erosion or deposition processes and (iii) artefacts due to the collection, preparation and measurement of the samples; (iv) finally, if none of the above can be assigned, this variation might be attributed to turbation processes (e.g. bioturbation, cryoturbation and mechanical turbation, such as avalanches or rockfalls). CheSS was exemplarily applied in one Swiss alpine valley where the apparent temporal variability called into question the suitability of the selected reference sites. In general we suggest the application of CheSS as a first step towards a comprehensible approach to test for the suitability of reference sites.
In Vitro Evaluation of Onlay Restorations on Primary Teeth
Authors: Güzel Kadriye G.U. , Altun Ayşe C. , Kirzioğlu Zuhal 
Published: August 2017

Purpose Many novel materials have been developed such as composite resin, ceramic, zircon or metal-supported ceramic for use in aesthetic restoration of primary teeth and permanent teeth with extensive crown damage. The aim of the present study was to compare microtensile bond strengths on materials using the microtensile bond strength test. Materials and methods The microtensile bond strength on the primary tooth dentin was measured on extracted primary teeth using an indirect method and fracture patterns were evaluated. Results The analysis of bond strengths using the Mann-Whitney U-test did not show significant difference between the rank averages of the compomer and composite resin (p = 0.741). The dentin sections, from which test samples were obtained, contributed to the bond strength; dentin samples obtained just above the pulp had lower bond strength, and the difference was statistically significant (p = 0.005). The adhesive type fracture was the most prevalent fracture type for both materials. Conclusions When the chemical, physiological, and micromorphological differences between primary and permanent teeth are taken into consideration, the success of the materials used for restorations can be different between primary and permanent teeth. Therefore, materials used in the dentistry must be evaluated separately for primary teeth.
A Randomized Comparison between an Intravenous Catheter System with a Retractable Guidewire and Conventional Intravenous Catheters
Authors: Chick Jeffrey Forris Beecham , Reddy Shilpa N. , Chen James X. , Sammarco Therese , Chittams Jesse , Trerotola Scott O. 
Published: August 2017

Introduction The aim of this study is to compare an intravenous (IV) catheter system which uses a retractable guidewire (RG-IV) designed to facilitate IV placement with a conventional IV (C-IV) catheter control. Materials and methods A prospective, randomized design was used. Patients referred to interventional radiology for outpatient procedures were offered participation. Enrollment occurred between August and November 2013. Patients were assigned to receive the RG-IV or C-IV in a 1:1 randomization scheme. After assignment, up to three attempts by a registered nurse occurred with the assigned device; if all three attempts failed, crossover to the other device occurred. The primary outcome variable was first-attempt success at IV placement. Secondary outcome variables included patient and clinician satisfaction, number of attempts, and time to successful placement. Two hundred twenty patients were enrolled (139 men, 81 women) in the study. Results Of the 220 patients, two were withdrawn prior to IV attempt leaving 218 subjects, 109 in each group. First attempt success (77% RG-IV vs. 82% C-IV, p = 0.5), number of attempts to achieve IV access (1.26 RG-IV vs. 1.29 C-IV, p = 0.98), and time to achieve IV success (2.9 minutes RG-IV vs. 2.7 C-IV, p = 0.82) did not differ between groups. Patient satisfaction with insertion was higher in the C-IV group (4.5/5 vs. 3.9/5, p<0.001) although comfort comparison was not (3.3/5 RG-IV vs. 3.5/5 C-IV, p = 0.15). Conclusions In an interventional radiology outpatient population, the RG-IV and C-IV were comparable in first-attempt success, number of attempts, and time to achieve IV success. Patient satisfaction was higher with C-IV.
A mechanism of banding failure in excessively dilated fistulas
Authors: Mallios Alexandros , Lucas John , Jennings William 
Published: August 2017

Introduction: We present an unreported cause of banding failure for flow restriction in dramatically enlarged arteriovenous fistulas (AVFs). Case series: Four patients operated in different institutions by two different surgeons experienced band failure within 6 months of the initially successful operation for AVF flow restriction. Prior to the initial banding procedure, each patient’s AVF was noted to have major dilatation of the post-anastomotic segment (>2 cm). All patients required a second operation for flow reduction with reconstruction of the AVF anastomosis to a tapered, smaller size. During this second procedure, the suture tie used for banding in each patient was found to have eroded a portion of the vessel wall and was extending into the fistula lumen. No thrombosis or bleeding was encountered and all AVFs have remained functional after revision. Conclusions: Identical findings in these four patients suggest that the extensive infolding and caliber diameter reduction created by banding these massively dilated fistulas, when combined with the pulsatility induced in the pre-banding segment, leads to a gradual incorporation of the suture tie into the vessel wall and finally within the lumen. We suggest erosion of banding material and failure of flow reduction may occur with any technique but may be more likely with a single polypropylene suture restricting very large AVF. We suggest such excessively dilated fistulas requiring flow reduction may be successfully treated by reconstruction of the AVF anastomosis to a much smaller size with tapering of the outflow vein to accommodate the revision.
Atypical use of PICC in Infants and Small Children: A Unicentric Experience
Authors: Bernasconi Filippo , Zanaboni Clelia , Dato Andrea , Dolcino Andrea , Bevilacqua Michela , Montagnini Luigi , Disma Nicola 
Published: August 2017

Introduction The peripherally inserted central catheters (PICCs) are vascular access devices (VAD) that are increasingly being used in the pediatric population. If a small vein caliber prevents positioning the catheter in the arm, the following step is to position the same catheter in the supraclavicular area, which can be defined as an off-label use or “atypical” approach, first described by Pittiruti. Materials and methods We retrospectively reviewed PICC positioning with puncture-site in the supra-clavicular area (“atypical” PICC insertion) and then tunneled on the chest. Results Nineteen atypical PICCs were positioned in 18 patients. The median age of patients at the day of implant was 14 months (IQR 3-27 months), and weight 7.5 kg (IQR 4-12 kg). Within this population, 74% of cases scheduled for a typical PICC insertion presented vein caliber too small for this procedure. For this reason, the typical PICC insertion was changed in favor of an atypical PICC procedure. Atypical PICCs were successfully used in 100% of cases without immediate complications. Conclusions Atypical PICC positioning is a safe and useful alternative to the conventional technique when there is need for a central vascular access device (CVAD) for mid- or long-term therapy.
The NeutraClear® Needleless Connector is Equally Effective against Catheter Colonization Compared to MicroClave®
Authors: Guembe María , Pérez Granda María Jesús , Cruces Raquel , Alcalá Luis , Bouza Emilio 
Published: August 2017

Introduction Neutral-valve closed-system connectors can reduce the frequency of catheter colonization. Commercially available closed system connectors need to be tested and compared with each other to assess how they protect against contamination. We aimed to compare, in vitro, the efficacy of connectors NeutraClear® and MicroClave® against contamination under conditions of daily clinical practice. Methods The model consisted of a set of 200 blood culture bottles (BCBs) with a cannula inserted (100 closed with NeutraClear® and 100 closed with MicroClave®) that were assessed in two experiments while instilling 1 mL of saline: manipulation based on the standard of care and manipulation using gloves impregnated with a 0.05 McFarland Staphylococcus aureus solution. The BCBs were incubated in a BACTEC System at 37°C under continuous shaking for up to 7 days. When a bottle turned positive, 100 µL of the fluid was cultured. The positivity rate and time to positivity of the BCB in each experiment was compared. Results In the aseptic model in the NeutraClear® and MicroClave® groups, only 1 BCB and 2 BCBs were positive, respectively, (p = 0.55). In the contaminated model, all BCBs were positive in both groups at the end of the incubation time. We did not find differences for the MTP between NeutraClear® and MicroClave® (36.04 vs. 20.13 hours, p = 0.09). Conclusions The NeutraClear® needleless connector proved to be as efficient as the MicroClave® connector in the prevention of catheter colonization and migration of S. aureus from the surface to the inside of the hub in an in vitro model.
Postoperative Day 1 Access Blood Flow and Resistive Index can Predict Patency in Distal Forearm Arteriovenous Fistula
Authors: Shintaku Sadanori , Kawanishi Hideki , Moriishi Misaki , Ago Rika , Banshodani Masataka , Hashimoto Shinji , Tsuchiya Shinichiro 
Published: August 2017

Introduction Early access failure is an important complication of autogenous arteriovenous fistulas (AVFs). We prospectively monitored patients who underwent AVF creation using ultrasonography. Methods Color flow imaging was used to assess access blood flow in patients undergoing creation of a new AVF in the distal forearm preoperatively and at 1 day and 1 week postoperatively. We measured the flow volume (FV) and resistive index (RI) of the brachial artery, and the internal diameter of the brachial artery and outflow vein. The primary outcome was the primary patency of the AVF without percutaneous angioplasty (PTA) or surgical revision 40 days after access creation. Results We recruited 35 patients with newly created AVFs (men, 21; mean age, 73 years). Within one day of operation, the overall FV increased from 62 to 352 mL/min (p<0.0001) while the overall RI decreased from 1.0 to 0.63 (p<0.001). Five patients required PTA or surgical revision (intervention group [IG]), whereas 30 patients did not (non-intervention group [NIG]). The FV increased while the RI decreased from day 1 to week 1 in the NIG, but not in the IG (p<0.0001). The diameter of the brachial artery and outflow vein significantly increased in the NIG at 1 week. The FV of 235 mL/min and RI of 0.63 at 1 day were the thresholds for predicting early fistula failure. Conclusions Access FV and RI at 1 day after AVF creation can predict primary patency and help plan intervention.
Impaired Maturation of Arteriovenous Fistula for Haemodialysis Due to Forearm Artery Stenosis: Percutaneous Endovascular Treatment
Authors: Pirozzi Nicola , Scrivano Jacopo , Pirozzi Roberto , Cordova Emanuela , Punzo Giorgio , Menè Paolo 
Published: August 2017

Introduction Distal autogenous arteriovenous fistula (dAVF), considered the “gold standard” vascular access for haemodialysis, suffers from a high rate of impaired maturation. One of the usual causes is low-flow associated forearm arterial stenosis. In such cases, endovascular treatment by percutaneous transluminal angioplasty represents a helpful option to enable maturation of the vascular access. Currently, there are few reports concerning the treatment of this complication. Therefore, we describe our single-centre experience based on a retrospective review of prospectively collected data. Patients and methods We treated 18 consecutive patients from July 2007 to January 2014 (16 radio-cephalic, 2 ulno-basilic distal AVF). A low flow due to forearm artery stenosis was diagnosed by duplex examination, as routinely performed one month after dAVF creation. An anterograde trans-brachial access was used for a 4-mm high-pressure angioplasty of the stenosed artery. Results All interventions resulted in patent fistulas. Isolated percutaneous transluminal angioplasty (PTA) was required without need of stent placement. Mean blood flow increased from 304 mL/min, preoperatively, to 671 mL/min (p<0.01), as checked one week after the procedure. One-year primary and secondary patency were 84% ±7.3% and 92% ± 9.2%, respectively. Under no circumstances did access-induced distal ischemia occurred during follow-up. Conclusions Endovascular approach is a helpful and minimally invasive procedure for treatment of delayed maturation of dAVF related to forearm artery stenosis.
Long noncoding RNA CCAT1 promotes cell proliferation and metastasis in human medulloblastoma via MAPK pathway
Authors: Gao Ran , Zhang Rui , Zhang Cuicui , Zhao Li , Zhang Yue 
Published: August 2017

Background: Medulloblastoma is the most common posterior fossa tumor in children and one that easily metastasizes. The mechanisms of how the medulloblastoma develops and progresses remain to be elucidated. The present study aimed to assess the role of long noncoding colon cancer–associated transcript-1 (lncRNA CCAT1) in cell proliferation and metastasis in human medulloblastoma. Methods: Levels of CCAT1 were measured in samples and cell lines of medulloblastoma. Cell cycle progression, cell viability assay, colony formation assay, wound-healing and Transwell assays Corning, Cambridge, MA, USA were used to investigate the viability and motility of cells. Western blot assay was used to investigate the levels of CCAT1 and other proteins. Results: The initial findings indicated that CCAT1 was significantly up-regulated in clinical cancerous tissues and expressed differently in a series of medulloblastoma cell lines. CCAT1 knockdown significantly slowed cell proliferation rates and inhibited cell clonogenic potential in Daoy cells and D283 cells. Cell cycle progression was disrupted with cell proportions in the G0/G1 phase decreased and the proportion in the S phase and G2/M phases increased, in Daoy cells and D283 cells. Concordantly, medulloblastoma tumor cell growth rates were found to be impaired in xenotransplanted mice. After CCAT1 knockdown, cell wound recovery ability was significantly inhibited. Furthermore, the phosphorylated levels of MAPK, ERK and MEK, but not their total levels decreased after the down-regulation of CCAT1 in Daoy and D283 cells. Conclusions: Our results suggested that the lncRNA CCAT1 promotes cell proliferation and metastasis in human medulloblastoma by possibly regulating the MAPK pathway.
Changes of reduced glutathione and glutathione S-transferase levels in colorectal cancer patients undergoing treatment
Authors: Baltruskeviciene Edita , Kazbariene Birutė , Aleknavicius Eduardas , Krikstaponiene Aurelija , Venceviciene Lina , Suziedelis Kestutis , Stratilatovas Eugenijus , Didziapetriene Janina 
Published: August 2017

Purpose: The available data concerning reduced glutathione (GSH) and glutathione S-transferase (GST) levels in colorectal cancer patients during the treatment process are contradictory and insufficient. Methods: Forty patients with metastatic colorectal cancer receiving FOLFOX4 chemotherapy with or without bevacizumab and 40 healthy volunteers were included in the study. Blood samples were taken before treatment, after 2 months and at the end of treatment in the patient group and once in the healthy volunteer group. The levels of GSH and GST in blood serum were evaluated by enzyme-linked immunosorbent assay (ELISA) according to the manufacturer’s instructions. Results: The serum level of GSH was significantly lower in colorectal cancer patients before treatment than in healthy volunteers (37.84 ± 19.39 μg/mL and 52.78 ± 19.39 μg/mL, respectively; p<0.001). After treatment, the level of GSH increased significantly, while the level of GST decreased significantly. These changes were observed only in the groups of patients with partial or complete response, having metastases only in the liver, receiving FOLFOX4 chemotherapy with bevacizumab, or undergoing resection or radiofrequency ablation of liver metastases. Conclusions: GSH and GST levels change significantly during the treatment process and these changes depend on the response to treatment, treatment type, and site of metastases. Further analysis of the changes in GSH and GST levels during treatment would allow the assessment of the predictive potential of this molecular marker.
A aplicação do PMBOK® na gestão de projetos em unidades de informação
Authors: Spudeit Daniela Fernanda Assis de Oliveira , Ferenhof Helio Aisenberg 
Published: August 2017

Introdução: As unidades de informação estão cada vez mais sendo vistas como organizações prestadoras de serviços cujo principal insumo é a informação que agrega valor às instituições e formação do capital intelectual. Esse contexto aponta uma necessidade de planejamento para atendimento das necessidades informacionais dos seus clientes Objetivo: O objetivo deste estudo é apresentar a gestão de projetos como uma das alternativas para promover a eficácia no planejamento e execução em uma unidade de informação por meio de soluções que atendam à estas necessidades. Metodologia: Um estudo bibliográfico e exploratório foi conduzido em busca reforçar que o uso das melhores práticas de gerenciamento de projetos pode ajudar e muito a gestão de unidades de informação. Resultados: Como resultados obtidos, aponta-se que todas as dez áreas do PMBOK® são aplicáveis em unidades de informação e, cabe ao bibliotecário, promover a execução, acompanhamento e finalização desses processos.Conclusão: As unidades de informação têm como missão promover o acesso as fontes de informação e por isso é importante que sejam adotadas as boas práticas do PMBOK® pois aceleram o lançamento de produtos e serviços, reduzem custos, melhoram os controles de qualidade e otimizam recursos e esforços.
Pinaverium Bromide: Development and Validation of Spectrophotometric Methods for Assay and Dissolution Studies
Authors: Martins Danielly da Fonte Carvalho , Florindo Lorena Coimbra , Machado Anna Karolina Mouzer da Silva , Todeschini Vítor , Sangoi Maximiliano da Silva 
Published: August 2017

Abstract
This study presents the development and validation of UV spectrophotometric methods for the determination of pinaverium bromide (PB) in tablet assay and dissolution studies. The methods were satisfactorily validated according to International Conference on Harmonization guidelines. The response was linear (r2 &gt; 0.99) in the concentration ranges of 2–14 μg/mL at 213 nm and 10–70 μg/mL at 243 nm. The LOD and LOQ were 0.39 and 1.31 μg/mL, respectively, at 213 nm. For the 243 nm method, the LOD and LOQ were 2.93 and 9.77 μg/mL, respectively. Precision was evaluated by RSD, and the obtained results were lower than 2%. Adequate accuracy was also obtained. The methods proved to be robust using a full factorial design evaluation. For PB dissolution studies, the best conditions were achieved using a United States Pharmacopeia Dissolution Apparatus 2 (paddle) at 50 rpm and with 900 mL 0.1 M hydrochloric acid as the dissolution medium, presenting satisfactory results during the validation tests. In addition, the kinetic parameters of drug release were investigated using model-dependent methods, and the dissolution profiles were best described by the first-order model. Therefore, the proposed methods were successfully applied for the assay and dissolution analysis of PB in commercial tablets.
Coordenador pedagógico: revisão empírica dos resumos de teses e dissertações produzidas no Brasil de 1988 a 2012
Authors: Oliveira Jane Cordeiro de 
Published: August 2017

Este trabalho tem o objetivo de apresentar uma revisão empírica a respeito do coordenador pedagógico e a importância do estudo sobre este profissional tendo em vista sua relevância para estudos sobre gestão. Os dados foram coletados na base de dados da Capes no período de 1988 a 2012. Nota-se que houve um significativo crescimento de pesquisas no período entre 2006 e 2008. As pesquisas concentram-se, principalmente, em São Paulo com o maior número de trabalhos. As categorias encontradas foram: histórico da função coordenador pedagógico; identidade, função, constituição da função coordenador pedagógico; formação inicial e continuada do coordenador pedagógico; atuação do coordenador pedagógico na escola; relações entre o coordenador pedagógico e os demais profissionais da escola; opinião ou visão do coordenador pedagógico sobre diferentes situações do cotidiano escolar. Consideramos que as pesquisas a respeito do coordenador pedagógico são relevantes para a compreensão de seu papel e de todas as formas de atuação no espaço escolar. Palavras-chave: coordenador pedagógico, revisão empírica, teses e dissertações.