bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scaling up interventions for depression in sub-Saharan Africa: lessons from Zimbabwe
Authors: Chibanda D. , Verhey R. , Munetsi E. , Rusakaniko S. , Cowan F. , Lund C. 
Published: April 2016

BackgroundThere is a dearth of information on how to scale-up evidence-based psychological interventions, particularly within the context of existing HIV programs. This paper describes a strategy for the scale-up of an intervention delivered by lay health workers (LHWs) to 60 primary health care facilities in Zimbabwe.MethodsA mixed methods approach was utilized as follows: (1) needs assessment using a semi-structured questionnaire to obtain information from nurses (n = 48) and focus group discussions with District Health Promoters (n = 12) to identify key priority areas; (2) skills assessment to identify core competencies and current gaps of LHWs (n = 300) employed in the 60 clinics; (3) consultation workshops (n = 2) with key stakeholders to determine referral pathways; and (4) in-depth interviews and consultations to determine funding mechanisms for the scale-up.ResultsFive cross-cutting issues were identified as critical and needing to be addressed for a successful scale-up. These included: the lack of training in mental health, unavailability of psychiatric drugs, depleted clinical staff levels, unavailability of time for counseling, and poor and unreliable referral systems for people suffering with depression. Consensus was reached by stakeholders on supervision and support structure to address the cross-cutting issues described above and funding was successfully secured for the scale-up.ConclusionKey requirements for success included early buy-in from key stakeholders, extensive consultation at each point of the scale-up journey, financial support both locally and externally, and a coherent sustainability plan endorsed by both government and private sectors.
The Needham Puzzle Reconsidered: Organizations, Organizing, and Innovation in China
Authors: Augier Mie , Guo Jerry , Rowen Harry 
Published: April 2016

ABSTRACT
This paper discusses some aspects of innovation in China. As China seeks to transition to a knowledge-based economy, it may become more important for China to develop innovative technologies to sustain economic growth. How do China's history, culture, institutions, and organizations aid or hinder innovation? How does China's national innovation system compare to the innovation culture in the US, as well as other developed and emerging economies? What are the prospects for the future of the Chinese national innovation system?
Our starting point is the Needham Puzzle – the paradox that while China was once a world leader in technological development, it fell behind; the Industrial Revolution happened in Europe rather than in China. Potential explanations for the Needham Puzzle may shed light on the challenges facing innovation in modern China. We identify three factors that might help explain the Needham Puzzle; assess how the Needham Puzzle and Chinese culture and history have affected the modern innovation system; discuss comparative aspects of innovation ecosystems in the United States and elsewhere; and suggest that Chinese innovation emphasizes exploitation and refinement of existing knowledge to the exploration and development of new knowledge. We also discuss implications for the future of innovation in China.
Changes in life satisfaction when losing one's spouse: individual differences in anticipation, reaction, adaptation and longevity in the German Socio-economic Panel Study (SOEP)
Authors: INFURNA FRANK J. , WIEST MAJA , GERSTORF DENIS , RAM NILAM , SCHUPP JÜRGEN , WAGNER GERT G. , HECKHAUSEN JUTTA 
Published: April 2016

ABSTRACTLosing a spouse is among the most devastating events that may occur in people's lives. We use longitudinal data from 1,224 participants in the German Socio-economic Panel Study (SOEP) to examine (a) how life satisfaction changes with the experience of spousal loss; (b) whether socio-demographic factors and social and health resources moderate spousal loss-related changes in life satisfaction; and (c) whether extent of anticipation, reaction and adaptation to spousal loss are associated with mortality. Results reveal that life satisfaction shows anticipatory declines about two and a half years prior to (anticipation), steep declines in the months surrounding (reaction) and lower levels after spousal loss (adaptation). Older age was associated with steeper anticipatory declines, but less steep reactive declines. Additionally, younger age, better health, social participation and poorer partner health were associated with better adaptation. Higher pre-loss life satisfaction, less steep reactive declines and better adaptation were associated with longevity. The discussion focuses on the utility of examining the interrelatedness among anticipation, reaction and adaptation to further our understanding of change in life satisfaction in the context of major life events.
The ninth stage in the cycle of life – reflections on E. H. Erikson's theory
Authors: BUGAJSKA BEATA E. 
Published: April 2016

ABSTRACTIn the present paper, Erik H. Erikson's theory of psycho-social development is analysed, including a new, ninth stage proposed by his wife, Joan M. Erikson. However, a new understanding of the ninth stage is proposed, in which integrityversusdespair is still the crisis of the last stage of life regardless of the addition of the ninth stage. The crisis of stage eight takes place on the continuum between involvementversusresignation. The term ‘involvement’ is understood as the choice of one's own way of life in the world, in view of personal development oriented towards the realisation of universal values, in accordance with the ethical dimension of social ethos, and with a sense of acceptance of the changes that are the result of the human ageing process. ‘Resignation’, in turn, is understood as the second pole dynamising the conflict of stage eight, which manifests itself in the fact that no new activities are undertaken or old ones continued by an individual, out of the conviction that it is senseless to undertake any activities for his or her own development. There is, however, strength that can be engendered by the struggle of older people between involvement and resignation, namely courage. In the acquisition of courage, older people should be supported by geragogy of courage. Society needs the courage of older people and their involvement in the ethical preservation of the world.
Laser-induced fusion detonation wave
Authors: Eliezer S. , Ravid A. , Henis Z. , Nissim N. , Martinez Val J.M. 
Published: April 2016

AbstractDevelopment of a detonation wave due to α heating following short pulse laser irradiation in pre-compressed deuterium–tritium (DT) plasma is considered. The laser parameters required for development of a detonation wave are calculated. We find that a laser irradiance and energy of IL = 1.75 × 1023 W/cm2 and 12.8 kJ accordingly during 1.0 ps in a pre-compressed target at 900 g/cm3 creates an α heating fusion detonation wave. In this case, the nuclear fusion ignition conditions for the pre-compressed DT plasma are achieved along the detonation wave orbit.
How do size distributions relate to concurrently measured demographic rates? Evidence from over 150 tree species in Panama
Authors: Lima Renato A.F. , Muller-Landau Helene C. , Prado Paulo I. , Condit Richard 
Published: April 2016

Abstract:In stable populations with constant demographic rates, size distributions reflect size-dependent patterns of growth and mortality. However, population growth can also affect size distributions, which may not be aligned with current growth and mortality. Using 25 y of demographic data from the 50-ha Barro Colorado Island plot, we examined how interspecific variation in diameter distributions of over 150 tropical trees relates to growth–diameter and mortality–diameter curves and to population growth rates. Diameter distributions were more skewed in species with faster increases/slower decreases in absolute growth and mortality with diameter and higher population growth rates. The strongest predictor of the diameter distribution shape was the exponent governing the scaling of growth with diameter (partial R2 = 0.20–0.34), which differed among growth forms, indicating a role of life history variation. However, interspecific variation in diameter distributions was also significantly related to population growth rates (partial R2 = 0.03–0.23), reinforcing that many populations are not at equilibrium. Consequently, although fitted size distribution parameters were positively related to theoretical predictions based on current size-dependent growth and mortality, there was considerable deviation. These analyses show that temporally variable demographic rates, probably related to cyclic climate variation, are important influences on forest structure.
Care Perceptions among Residents of LTC Facilities Purporting to Offer Person-Centred Care
Authors: Donnelly Leeann , MacEntee Michael I. 
Published: April 2016

RÉSUMÉCette étude a exploré d’une manière qualitative comment les résidents des maisons de soins de longue durée (SLD) pensent et s’adaptent aux soins qu’ils reçoivent. Nous avons interrogé et observé un groupe délibérément choisi parmi des personnes âgées dans sept etablissements qui prétendent fournir des soins centrés sur la personne. Les descriptions interprétatives de la part de 43 entrevues personnelles avec 23 participants correspondaient a une réponse à la question: Comment les habitants perçoivent-ils les soins rendus dans les établissements de SLD qui se présentent comme offrant des soins centrés sur la personne? Trois thèmes dominants sont ressortis: (1) l’environnement bienveillant; (2) la préservation de la dignité; et (3) le maintien de l’autonomie personnelle. Les participants étaient sensibles à la charge de travail du personnel infirmier, mais se sentaient éloignés du personnel. Les participants ont donné des exemples de mauvais soins et une manque d’empathie, des indignités humains et des violations de l’autonomie personnelle causées par les politiques institutionnelles qu’ils se sentaient inhibiter leur capacité à recevoir des soins selon leurs propres préférences. En général, ils ont contesté les allégations de soins centrés sur la personne, mais ils s’y sont adaptés pour faire face à un environnement qui menace leur dignité et leur autonomie.
A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells
Authors: Saxena Pratik , Heng Boon Chin , Bai Peng , Folcher Marc , Zulewski Henryk , Fussenegger Martin 
Published: April 2016

AbstractSynthetic biology has advanced the design of standardized transcription control devices that programme cellular behaviour. By coupling synthetic signalling cascade- and transcription factor-based gene switches with reverse and differential sensitivity to the licensed food additive vanillic acid, we designed a synthetic lineage-control network combining vanillic acid-triggered mutually exclusive expression switches for the transcription factors Ngn3 (neurogenin 3; OFF-ON-OFF) and Pdx1 (pancreatic and duodenal homeobox 1; ON-OFF-ON) with the concomitant induction of MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homologue A; OFF-ON). This designer network consisting of different network topologies orchestrating the timely control of transgenic and genomic Ngn3, Pdx1 and MafA variants is able to programme human induced pluripotent stem cells (hIPSCs)-derived pancreatic progenitor cells into glucose-sensitive insulin-secreting beta-like cells, whose glucose-stimulated insulin-release dynamics are comparable to human pancreatic islets. Synthetic lineage-control networks may provide the missing link to genetically programme somatic cells into autologous cell phenotypes for regenerative medicine.
RETRACTED ARTICLE: A natural food sweetener with anti-pancreatic cancer properties
Authors: Liu C , Dai L-H , Dou D-Q , Ma L-Q , Sun Y-X 
Published: April 2016

AbstractMogroside V is a triterpenoid isolated from the traditional Chinese medical plant Siraitia grosvenorii. Mogroside V has a high degree of sweetness and a low calorific content. Herein, we found that mogroside V possesses tumor growth inhibitory activity in in vitro and in vivo models of pancreatic cancer by promoting apoptosis and cell cycle arrest of pancreatic cancer cells (PANC-1 cells), which may in part be mediated through regulating the STAT3 signaling pathway. These results were confirmed in vivo in a mouse xenograft model of pancreatic cancer. In xenograft tumors, Ki-67 and PCNA, the most commonly used markers of tumor cell proliferation, were downregulated after intravenous administration of mogroside V. Terminal deoxynucleotidyl transferase dUTP nick end labeling assays showed that mogroside V treatment promoted apoptosis of pancreatic cancer cells in the xenograft tumors. Furthermore, we found that mogroside V treatment significantly reduced the expression of CD31-labeled blood vessels and of the pro-angiogenic factor vascular endothelial growth factor in the xenografts, indicating that mogroside V might limit the growth of pancreatic tumors by inhibiting angiogenesis and reducing vascular density. These results therefore demonstrate that the natural, sweet-tasting compound mogroside V can inhibit proliferation and survival of pancreatic cancer cells via targeting multiple biological targets.
A multi-decade dataset of monthly beach profile surveys and inshore wave forcing at Narrabeen, Australia
Authors: Turner Ian L. , Harley Mitchell D. , Short Andrew D. , Simmons Joshua A. , Bracs Melissa A. , Phillips Matthew S. , Splinter Kristen D. 
Published: April 2016

AbstractLong-term observational datasets that record and quantify variability, changes and trends in beach morphology at sandy coastlines together with the accompanying wave climate are rare. A monthly beach profile survey program commenced in April 1976 at Narrabeen located on Sydney’s Northern Beaches in southeast Australia is one of just a handful of sites worldwide where on-going and uninterrupted beach monitoring now spans multiple decades. With the Narrabeen survey program reaching its 40-year milestone in April 2016, it is timely that free and unrestricted use of these data be facilitated to support the next advances in beach erosion-recovery modelling. The archived dataset detailed here includes the monthly subaerial profiles, available bathymetry for each survey transect extending seawards to 20 m water depth, and time-series of ocean astronomical tide and inshore wave forcing at 10 m water depths, the latter corresponding to the location of individual survey transects. In addition, on-going access to the results of the continuing monthly survey program is described.
Inhibition of HSV-1 Replication by Gene Editing Strategy
Authors: Roehm Pamela C. , Shekarabi Masoud , Wollebo Hassen S. , Bellizzi Anna , He Lifan , Salkind Julian , Khalili Kamel 
Published: April 2016

AbstractHSV-1 induced illness affects greater than 85% of adults worldwide with no permanent curative therapy. We used RNA-guided CRISPR/Cas9 gene editing to specifically target for deletion of DNA sequences of the HSV-1 genome that span the region directing expression of ICP0, a key viral protein that stimulates HSV-1 gene expression and replication. We found that CRISPR/Cas9 introduced InDel mutations into exon 2 of the ICP0 gene profoundly reduced HSV-1 infectivity in permissive human cell culture models and protected permissive cells against HSV-1 infection. CRISPR/Cas9 mediated targeting ICP0 prevented HSV-1-induced disintegration of promonocytic leukemia (PML) nuclear bodies, an intracellular event critical to productive HSV-1 infection that is initiated by interaction of the ICP0 N-terminus with PML. Combined treatment of cells with CRISPR targeting ICP0 plus the immediate early viral proteins, ICP4 or ICP27, completely abrogated HSV-1 infection. We conclude that RNA-guided CRISPR/Cas9 can be used to develop a novel, specific and efficacious therapeutic and prophylactic platform for targeted viral genomic ablation to treat HSV-1 diseases.
How to describe disordered structures
Authors: Nishio Kengo , Miyazaki Takehide 
Published: April 2016

AbstractDisordered structures such as liquids and glasses, grains and foams, galaxies, etc. are often represented as polyhedral tilings. Characterizing the associated polyhedral tiling is a promising strategy to understand the disordered structure. However, since a variety of polyhedra are arranged in complex ways, it is challenging to describe what polyhedra are tiled in what way. Here, to solve this problem, we create the theory of how the polyhedra are tiled. We first formulate an algorithm to convert a polyhedron into a codeword that instructs how to construct the polyhedron from its building-block polygons. By generalizing the method to polyhedral tilings, we describe the arrangements of polyhedra. Our theory allows us to characterize polyhedral tilings and thereby paves the way to study from short- to long-range order of disordered structures in a systematic way.
Helical Majorana fermions in "Equation missing" -wave topological superconductivity of doped correlated quantum spin Hall insulators
Authors: Sun Shih-Jye , Chung Chung-Hou , Chang Yung-Yeh , Tsai Wei-Feng , Zhang Fu-Chun 
Published: April 2016

AbstractThere has been growing interest in searching for exotic self-conjugate, charge-neutral low-energy fermionic quasi-particles, known as Majorana fermions (MFs) in solid state systems. Their signatures have been proposed and potentially observed at edges of topological superconcuctors with non-trivial topological invariant in the bulk electronic band structure. Much effort have been focused on realizing MFs in odd-parity superconductors made of strong spin-orbit coupled materials in proximity to conventional superconductors. In this paper, we propose a novel mechanism for realizing MFs in 2D spin-singlet topological superconducting state induced by doping a correlated quantum spin Hall (Kane-Mele) insulator. Via a renormalized mean-field approach, the system is found to exhibits time-reversal symmetry (TRS) breaking "Equation missing"-wave (chiral d–wave) superconductivity near half-filling in the limit of large on-site repulsion. Surprisingly, however, at large spin-orbit coupling, the system undergoes a topological phase transition and enter into a new topological phase protected by a pseudo-spin Chern number, which can be viewed as a persistent extension of the quantum spin Hall phase upon doping. From bulk-edge correspondence, this phase is featured by the presence of two pairs of counter-propagating helical Majorana modes per edge, instead of two chiral propagating edge modes in the d + id′ superconductors.
Lipid-mediated Protein-protein Interactions Modulate Respiration-driven ATP Synthesis
Authors: Nilsson Tobias , Lundin Camilla Rydström , Nordlund Gustav , Ädelroth Pia , von Ballmoos Christoph , Brzezinski Peter 
Published: April 2016

AbstractEnergy conversion in biological systems is underpinned by membrane-bound proton transporters that generate and maintain a proton electrochemical gradient across the membrane which used, e.g. for generation of ATP by the ATP synthase. Here, we have co-reconstituted the proton pump cytochrome bo3 (ubiquinol oxidase) together with ATP synthase in liposomes and studied the effect of changing the lipid composition on the ATP synthesis activity driven by proton pumping. We found that for 100 nm liposomes, containing 5 of each proteins, the ATP synthesis rates decreased significantly with increasing fractions of DOPA, DOPE, DOPG or cardiolipin added to liposomes made of DOPC; with e.g. 5% DOPG, we observed an almost 50% decrease in the ATP synthesis rate. However, upon increasing the average distance between the proton pumps and ATP synthases, the ATP synthesis rate dropped and the lipid dependence of this activity vanished. The data indicate that protons are transferred along the membrane, between cytochrome bo3 and the ATP synthase, but only at sufficiently high protein densities. We also argue that the local protein density may be modulated by lipid-dependent changes in interactions between the two proteins complexes, which points to a mechanism by which the cell may regulate the overall activity of the respiratory chain.
Oxygen vacancies controlled multiple magnetic phases in epitaxial single crystal Co0.5(Mg0.55Zn0.45)0.5O1-v thin films
Authors: Zhu Dapeng , Cao Qiang , Qiao Ruimin , Zhu Shimeng , Yang Wanli , Xia Weixing , Tian Yufeng , Liu Guolei , Yan Shishen 
Published: April 2016

AbstractHigh quality single-crystal fcc-Cox(MgyZn1-y)1-xO1-v epitaxial thin films with high Co concentration up to x = 0.5 have been fabricated by molecular beam epitaxy. Systematic magnetic property characterization and soft X-ray absorption spectroscopy analysis indicate that the coexistence of ferromagnetic regions, superparamagnetic clusters, and non-magnetic boundaries in the as-prepared Cox(MgyZn1-y)1-xO1-v films is a consequence of the intrinsic inhomogeneous distribution of oxygen vacancies. Furthermore, the relative strength of multiple phases could be modulated by controlling the oxygen partial pressure during sample preparation. Armed with both controllable magnetic properties and tunable band-gap, Cox(MgyZn1-y)1-xO1-v films may have promising applications in future spintronics.
Restoring electronic coherence/decoherence for a trajectory-based nonadiabatic molecular dynamics
Authors: Zhu Chaoyuan 
Published: April 2016

AbstractBy utilizing the time-independent semiclassical phase integral, we obtained modified coupled time-dependent Schrödinger equations that restore coherences and induce decoherences within original simple trajectory-based nonadiabatic molecular dynamic algorithms. Nonadiabatic transition probabilities simulated from both Tully’s fewest switches and semiclassical Ehrenfest algorithms follow exact quantum electronic oscillations and amplitudes for three out of the four well-known model systems. Within the present theory, nonadiabatic transitions estimated from statistical ensemble of trajectories accurately follow those of the modified electronic wave functions. The present theory can be immediately applied to the molecular dynamic simulations of photochemical and photophysical processes involving electronic excited states.
Carboxyl-terminal fusion of E7 into Flagellin shifts TLR5 activation to NLRC4/NAIP5 activation and induces TLR5-independent anti-tumor immunity
Authors: Lin Kuo-Hsing , Chang Li-Sheng , Tian Chun-Yuan , Yeh Yi-Chen , Chen Yu-Jie , Chuang Tsung-Hsien , Liu Shih-Jen , Leng Chih-Hsiang 
Published: April 2016

AbstractFlagellin has the capacity to activate both Toll-like receptor 5 (TLR5) and Nod-like receptor C4 (NLRC4)/neuronal apoptosis inhibitory protein 5 (NAIP5) inflammasome signaling. We fused E7m (the inactivated E7 of human papillomavirus) to either end of the flagellin protein, and the resulting recombinant flagellin-E7m proteins (rFliCE7m and rE7mFliC) were used as immunogens. Both fusion proteins activated receptor signaling to different degrees. rE7mFliC-induced TLR5 activity was 10-fold higher than that of rFliCE7m, whereas rFliCE7m activated the NLRC4/NAIP5 pathway more strongly. Therefore, these recombinant proteins provided a tool to investigate which signaling pathway is critical for the induction of antigen-specific T cell responses and anti-tumor immunity. We demonstrated that rFliCE7m induced higher levels of E7-specific IFN-gamma-secreting cells and cytotoxic T lymphocytes (CTLs) than rE7mFliC, and a single injection with rFliCE7m but not rE7mFliC inhibited E7-expressing tumor growth in vivo. Furthermore, we confirmed that CD8+ T cells played a major role in the anti-tumor immunity induced by rFliCE7m. These findings suggested that the NLRC4/NAIP5 intracellular signaling pathway was critical for the induction of anti-tumor immunity. These observations provide important information for the rational design of flagellin-based immunotherapy.