bluuebunny/crossref_metadata_2025_split huggingface dataset:
Helicobacter pylori, gastric cancer and other gastrointestinal malignancies
Authors: Venerito Marino , Vasapolli Riccardo , Rokkas Theodore , Delchier Jean‐Charles , Malfertheiner Peter 
Published: September 2017

AbstractIn a retrospective study performed in California, U.S.A., ca. 3% of patients with gastric intestinal metaplasia (GIM) developed gastric cancer (GC) within a median time period of 4.6 years after diagnosis of GIM. This observation stresses the importance of targeted surveillance even in regions with a low GC prevalence. Patients with alcoholic liver disease as well as survivors of colorectal and lobular breast cancer were found to be at increased risk of secondary GC. A population‐based Chinese study confirmed “serologic biopsy” as a useful screening tool for stratifying the individual risk of developing GC. Concerning GC therapy, a post hoc analysis of the MAGIC trial reported that regression of lymph node metastases, but not the tumor regression itself, predicts overall survival. Furthermore, in patients with high microsatellite instable tumors, perioperative chemotherapy leads to an increased risk of mortality. Two studies confirmed that eradication therapy is worthwhile as an initial treatment for gastric mucosa‐associated lymphoid tissue (MALT) lymphoma irrespective of the H. pylori infection status and stage. An increased risk of a second primary malignancy including GC was observed in these patients treated with immuno/chemotherapy but not in patients treated solely with an H. pylori eradication treatment. With respect to gastrointestinal malignancies other than GC, discrepant data have been published regarding the association of H. pylori with pancreatic cancer whereas no association has been reported with esophageal squamous cell carcinoma. The majority of published studies still support an association of H. pylori with colon neoplasms.
Rapid initial recovery and long‐term persistence of a bee community in a former landfill
Authors: Onuferko Thomas M. , Skandalis Dimitri A. , León Cordero Rodrigo , Richards Miriam H. 
Published: September 2017

Abstract

The effects of habitat restoration are usually studied using cross‐sectional comparisons of species assemblages among sites of various ages or disturbance levels. Longitudinal studies, however, are necessary for detecting long‐term responses to habitat restoration and for understanding annual demographic variation.

To investigate the time course of bee community restoration in sites previously made uninhabitable by anthropogenic disturbance, we studied a former landfill site for 10 years from initial revegetation in 2003 until 2013, comparing two restored sites with three nearby, undisturbed control sites. We used permutational multivariate analysis of variance and generalised additive mixed models to investigate how bee abundance and species richness varied over time (years), between seasons and between restoration levels.

Landfill restoration and the creation of foraging and nesting habitat resulted in rapid and persistent occupation by bees, suggesting that efforts to restore bee communities can be successful when a source of colonists exists nearby.

Based on earlier studies, we predicted that in restored sites there would be an initial rapid increase in bee abundance and species richness, followed by a decline to a stable intermediate level. This prediction was supported as bee abundance and species richness in restored sites increased until 2006/2007 and subsequently declined.

In control sites, there were significant declines in abundance and species richness over time, despite a lack of anthropogenic disturbance. Possible contributors are changing weather patterns, especially severe droughts; plant community succession resulting in loss of bare ground for nesting sites; and increasing suburbanisation of the surrounding landscape.
Determination and distribution of biogenic amines in bee pollen
Authors: Zhao Lingling , Qi Suzhen , Liang Xinwen , Shan Jihao , Cao Wei , Wu Liming , Xue Xiaofeng 
Published: September 2017

AbstractThe natural decomposition of proteins yields peptides and amino acids, which are susceptible to further decay, resulting in formation of biogenic amines (BAs) in proteinaceous foods such as bee pollen (BP). However, excessive consumption of BAs will bring side effects, so it is vital to study the presence of BAs in BP. In this study, a sensitive and reliable ultra‐high‐performance liquid chromatography–tandem mass spectrometric method was used for the determination of 12 BAs in BP. Large variations in the distribution and levels of BAs were observed with its total concentrations ranging from 6837.4 to 25444.2 μg kg−1. In addition, the changes in the levels of BAs during storage and fermentation were preliminarily investigated. The results showed that fermentation significantly altered the quantities of BAs in rape BP, while changes during storage were modest. The results of this study could be applied for quality evaluation and risk assessment of BP in near future.
Effect of consecutive steeping on antioxidant potential of green, oolong and black tea
Authors: Islam Shaikh N. , Farooq Sumaya , Sehgal Amit 
Published: September 2017

SummaryAfter water, tea is considered to be one of the most consumed drinks worldwide. To get the maximum benefit from the whole‐leaf teas, the manufacturers provide instruction that these teas can be steeped 2–3 times over 6–8 h. In this study, the effect of consecutive steeping on radical‐scavenging ability of whole leaf green tea (unfermented), oolong tea (partially fermented) and black tea (fully fermented) was determined. Green tea showed the highest level of antioxidant activity, total phenolic and flavonoid content followed by oolong tea and black tea irrespective of the number of steeping done. The result also demonstrated that re‐steeping reduced the antioxidant potential of teas. Moreover, it was revealed that green tea is the best candidate for re‐steeping followed by oolong and then black tea.
Polyphenols, ascorbic acid and antioxidant capacity of commercial nutritional drinks, fruit juices, smoothies and teas
Authors: Abountiolas Marvin , do Nascimento Nunes Cecilia 
Published: September 2017

SummaryPolyphenols of plant origin have received special interest in the last decade because of their potential health benefits. Consequently, many beverages with words ‘antioxidant’ and ‘polyphenols’ have been developed. However, many of the claims are misleading because some beverages so labelled have either no or minimal levels of polyphenols. The objectives of this study were to quantify polyphenols (TPC) and ascorbic acid contents and antioxidant capacity (AOC) of different beverages; identify major polyphenols in beverages that showed higher TPC; correlate the claim on the label with TPC and AOC; and determine the impact of consumer refrigerated storage on TPC and AOC of aronia, blackcurrant and pomegranate juices which contained the most TPC and AOC. Major polyphenols identified from these juices included anthocyanins, myricetin and epicatechin. TPC of aronia, blackcurrant and pomegranate juices was relatively stable during consumer refrigerated storage, even when the juice had been intermittently exposed to air.
Management and implementation of intermittent catheterization in neurogenic lower urinary tract dysfunction
Authors: Böthig Ralf , Geng Veronika , Kurze Ines 
Published: September 2017

ABSTRACTAs a considerable heterogeneity in the procedure of intermittent catheterization (IC) was identified by a questionnaire survey conducted in hospitals and institutions for the treatment of patients with spinal cord injury in 2010, it became necessary to standardize the IC procedure (i.e. self‐catheterization and assisted catheterization). These guidelines were developed within a structured consensus process (e.g. several consensus conferences and nominal group process) by members of the working group on neuro‐urology and the working group on nursing of the German‐speaking Medical Society of Paraplegia and were published as guidelines of the German Society of Urology (DGU). The guidelines developer group was a multiprofessional group. Firstly, the indications for IC are presented and concepts such as sterile, aseptic and hygienic catheterization are defined. The materials necessary for the IC are presented in detail. The disinfection and catheterization techniques are described and a detailed explanation of the potential complications and their management is given. Finally, the legal aspects and issues of eligibility of catheter materials are discussed. The purpose of this consensus is to contribute to the standardization of IC. It should remove uncertainty and offer assistance to users (i.e. patients, staff and care providers). A particular focus is placed on practical instructions for carrying out the IC. The intention is to support the realization of IC in various settings (e.g. hospital, rehabilitation, long‐term care institutions and home‐based care). A wide implementation of the guidelines should lead to a reduction of the risks and complications of IC.
De novo activating epidermal growth factor mutations (EGFR) in small‐cell lung cancer
Authors: Thai Alesha , Chia Puey L. , Russell Prudence A. , Do Hongdo , Dobrovic Alex , Mitchell Paul , John Thomas 
Published: September 2017

AbstractIn Australia, mutations in epidermal growth factor mutations (EGFR) occur in 15% of patients diagnosed with non‐small‐cell lung cancer and are found with higher frequency in female, non‐smokers of Asian ethnicity. Activating mutations in the EGFR gene are rarely described in SCLC. We present two cases of de novo EGFR mutations in patients with SCLC detected in tissue and in plasma cell free DNA, both of whom were of Asian ethnicity and never‐smokers. These two cases add to the growing body of evidence suggesting that screening for EGFR mutations in SCLC should be considered in patients with specific clinical features.
Reflection on stroke deaths and end‐of‐life stroke care
Authors: Quadri Syed Z. , Huynh Thang , Cappelen‐Smith Cecilia , Wijesuriya Nirupama , Mamun Abul , Beran Roy G. , McDougall Alan J. , Cordato Dennis 
Published: September 2017

AbstractBackgroundThe benefit of palliative care referral for severe stroke patients on end‐of‐life care pathway (EOLCP) is increasingly recognised. Palliative care provides assistance with symptom management and transition to end‐of‐life care. Advance care planning (ACP) may help accommodate patient/family expectations and guide management.MethodsThis is a retrospective study of all stroke deaths (2014–2015) at Liverpool Hospital, Sydney, Australia. Data examined included age, comorbidities, living arrangements, pre‐existing ACP, palliative care referral rates and ‘survival time’.ResultsIn total, 123 patient (mean age ± SD = 76 ± 13 years) deaths were identified from 1067 stroke admissions (11.5% mortality); 64 (52%) patients had ischaemic stroke and 59 (48%) intracerebral haemorrhage (ICH), and 40% suffered a prior stroke, and 43% required a carer at home or were in an aged care facility. Survival time from admission was significantly longer in patients with ischaemic stroke compared to intracerebral haemorrhage (median, interquartile range [IQR]: 9.5 [18] vs 2 [4] days, P < 0.001). Only two patients had pre‐existing ACP; 44% of patients were referred to palliative care and 41% were commenced on dedicated EOLCP. Palliative care referral was less likely in patients who died under neurosurgery. EOLCP were significantly less likely to be commenced in patients who underwent acute intervention or were not referred to palliative care.ConclusionIn this cohort, palliative care referral and EOLCP were commenced in less than 50% of patients, highlighting significant variations in clinical care. These data support the need to promote awareness of ACP, particularly in patients with prior stroke or significant comorbidities. This may help reduce potentially futile invasive investigations and treatment.
Association between coffee consumption and risk of renal cell carcinoma: a meta‐analysis
Authors: Wijarnpreecha Karn , Thongprayoon Charat , Thamcharoen Natanong , Panjawatanan Panadeekarn , Cheungpasitporn Wisit 
Published: September 2017

AbstractBackground/ObjectivesThe risk of renal cell carcinoma (RCC) in individuals who regularly drink coffee is controversial. Several antioxidant compounds in coffee have been proposed to reduce the risk of RCC, while the findings from several studies raise concerns regarding a potential increased risk of RCC with coffee consumption.AimThis meta‐analysis aims to evaluate the association between coffee consumption and RCC.MethodsA literature search was performed using MEDLINE, EMBASE and Cochrane Database of Systematic Reviews from inception until December 2016. Studies that reported odd ratios or hazard ratios comparing the risk of RCC in individuals who consumed a significant amount of coffee (at least one cup of coffee per day) versus those who did not consume coffee were included. Pooled risk ratios (RR) and 95% confidence intervals (CI) were computed using a random‐effect, generic inverse variance method.ResultsTwenty‐two observational studies (16 case–control and 6 cohort studies) were included in our analysis to assess the association between RCC and coffee consumption. The pooled RR of RCC in individuals consuming coffee was 0.99 (95% CI, 0.89–1.11). Subgroup analyses stratified by gender showed pooled RRs of RCC of 1.15 (95% CI, 0.85–1.55) in females and 0.87 (95% CI, 0.72–1.04) in males.ConclusionsOur study demonstrates no significant association between coffee consumption and RCC. Thus, coffee consumption is likely not a risk factor for RCC. Whether coffee consumption has a potential role in reduced risk of RCC, particularly in men, requires further investigations.
Invariant natural killer T‐cell development and function with loss of microRNA‐155
Authors: Frias Adolfo B. , Buechel Heather M. , Neupane Arpan , D'Cruz Louise M. 
Published: September 2017

SummaryInvariant natural killer T (iNKT) cells are adaptive T cells with innate‐like characteristics including rapid cytokine production and a proliferative response to stimulation. Development of these cells in the thymus is dependent on expression of the microRNA (miRNA) processing enzyme Dicer, indicating that iNKT cells probably have distinct miRNA requirements for gene regulation during development. The miRNA miR‐155 has previously been shown to have numerous roles in T cells, including regulation of proliferation and differentiation, and positive modulation of interferon‐γ expression. We examined the role of miR‐155 in the development and function of iNKT cells. Using germline‐deficient miR‐155 mice, we showed that loss of miR‐155 resulted in unchanged iNKT cell frequency and cell number. Although miR‐155 was up‐regulated in iNKT cells upon activation with α‐galactosylceramide, loss of miR‐155 did not affect cytokine production or proliferation by iNKT cells. Hence, cytokine production occurs in iNKT cells independently of miR‐155 expression.
Combustion synthesis of InSe, In2Se3, and GaSe
Authors: Liu Guanghua , Chen Kexin , Li Jiangtao 
Published: September 2017

AbstractInSe, In2Se3, and GaSe are important III‐VI semiconductors and are attractive for electronic, optical, and optoelectronic applications. This paper reports a fast and cheap way called combustion synthesis to prepare InSe, In2Se3, and GaSe. Bulk samples with relative densities up to 98% are directly produced in a few seconds. The samples show a high phase purity, correct stoichiometry, and lamellar crystals larger than 100 μm. By optical absorption, the bandgaps of InSe, In2Se3, and GaSe are determined to be 1.08, 1.24 and 1.75 eV, respectively.
High‐temperature oxidation and compressive strength of Cr2AlC MAX phase foams with controlled porosity
Authors: Gonzalez‐Julian Jesus , Onrubia Sara , Bram Martin , Broeckmann Christoph , Vassen Robert , Guillon Olivier 
Published: September 2017

AbstractCr2AlC foams have been processed for the first time containing low (35 vol%), intermediate (53 vol%), and high (75 vol%) content of porosity and three ranges of pore size, 90‐180 μm, 180‐250 μm, and 250‐400 μm. Sacrificial template technique was used as the processing method, utilizing NH4HCO3 as a temporary pore former. Cr2AlC foams exhibited negligible oxidation up to 800°C and excellent response up to 1300°C due to the in‐situ formation of an outer thin continuous protective layer of α‐Al2O3. The in‐situ α‐Al2O3 protective layer covered seamlessly all the external surface of the pores, even when they present sharp angles and tight corners, reducing significantly the further oxidation of the foams. The compressive strength of the foams was 73 and 13 MPa for 53 vol% and 75 vol% porosity, respectively, which increased up to 128 and 24 MPa after their oxidation at 1200°C for 1 hour. The increase in the compressive strength after the oxidation was caused by the switch from inter‐ to transgranular fracture mode. According to the excellent high‐temperature response, heat exchangers and catalyst supports are the potential application of these foams.
What Drives Political Parties' Commitment to the ‘Stability Culture’? An Empirical Analysis Based on the Electoral Manifestos Issued in EU Member States
Authors: De Simone Elina , Gaeta Giuseppe Lucio , Sapio Alessandro 
Published: September 2017

AbstractBy using data extracted from the political manifestos released by national political parties from 27 European Union countries over the 1990–2012 period, we estimate non‐linear econometric models whose aim is to understand the determinants of cross‐country political concern for the ‘stability culture’. This expression describes an economic policy perspective based on the aims of providing price stability, fiscally disciplined budgets and rules and procedures that favour public expenditure ceilings. Our findings reveal that parties' commitment to the ‘stability culture’ is determined by their ideological background and by the national macroeconomic situation in the pre‐electoral year.
Investor protection and value creation in cross‐border M&As by emerging economies
Authors: Dell'Acqua Alberto , Etro Leonardo , Piva Michele , Teti Emanuele 
Published: September 2017

AbstractPrevious research investigating cross‐border M&As (CBM&As) by emerging economies (EEs) provided contrasting evidence on the value enhancement role of investor protection rules. We conduct a new empirical study to address the issue with an accurate sample selection of bidders from more homogeneous developing countries and transactions on developed countries only. Our analysis over the 1997–2012 period on a sample of M&A deals by companies from Brazil, Russia, India, China, and South Africa (BRICS) does not provide evidence that better institutional standards in the destination country are rewarded by the local stock market. We find that foreign governance quality is not associated with positive excess stock returns around the announcement date. Rather, these returns are affected by firm‐specific and deal‐specific factors, such as the relative deal size, the listed status of the target company, and the acquirer size. Comparison with other studies on excess returns for emerging markets (including BRICs) suggests that the results could be driven at least partially by country choice.
Evolution of Bilateral Capital Flows to Developing Countries at Intensive and Extensive Margins
Authors: ARAUJO JULIANA D. , LASTAUSKAS POVILAS , PAPAGEORGIOU CHRIS 
Published: September 2017

AbstractMotivated by the rise in capital flows to low‐income countries (LICs), we examine the nature of these flows and the factors affecting foreign investors' decision. Recognizing the presence of fixed investment costs, we analyze capital flows at both intensive and extensive margins. To fix ideas, we resort to the gravity literature for the estimating relationships which we embed into a two‐tier econometric framework with cross‐sectional dependence. Our main finding is that market entry costs are statistically and economically very detrimental to LICs. We also obtain the gravity‐type relationship for the destination income unconditionally but not after conditioning on relevant variables, as well as establish labor productivity as a robust attractor of capital inflows.
Myoma and myomectomy: Poor evidence concern in pregnancy
Authors: Milazzo Giusi Natalia , Catalano Angelica , Badia Valentina , Mallozzi Maddalena , Caserta Donatella 
Published: September 2017

AbstractAimSummarize the results of the many, but often underpowered, studies on pregnancy complicated by myoma or myomectomy.MethodsSurvey of the electronic PubMed database for the last two decades was conducted. We selected reviews, meta‐analyses, case series, case reports, clinical studies only with statistical analysis, and guidelines from scientific societies.ResultsDelaying childbearing leads to an increased incidence of pregnancy complicated by fibroids or previous myomectomy. Approximately 10–30% of pregnant women with myomas develop complications during gestation, at delivery and in puerperium. Submucosal, retroplacental, large and multiple myomas have a greater risk of complications. Cervical myomas, although rare, need careful management. The location and size of the fibroids should be assessed from the first trimester. Despite the increased risk of cesarean section, fibroids are not a contraindication to labor, unless they obstruct the birth canal or other obstetric conditions coexist. Myomectomy during pregnancy, in selected cases, is feasible and safe. Myomectomy cannot be considered a prophylactic measure prior to conception, but has to be individualized. Uterine rupture after myomectomy generally occurs in the third trimester or during labor and some associated risk factors have been identified. There is no consensus on the optimal interval between myomectomy and conception.ConclusionsPregnancy in patients with fibroids or previous myomectomy should be considered as high risk, requiring a maternal–fetal medicine specialist. To date available literature is inconsistent on evidence‐based management. Further research is needed for definitive recommendations.
Annual Report of the Committee on Gynecologic Oncology, Japan Society of Obstetrics and Gynecology: Patient Annual Report for 2014 and Treatment Annual Report for 2009
Authors: Saito Toshiaki , Takahashi Fumiaki , Katabuchi Hidetaka ,   The 2016 Committee on Gynecologic Oncology of the Japan Society of Obstetrics and Gynecology
Published: September 2017

AbstractThe Japan Society of Obstetrics and Gynecology collects and analyzes annual data on gynecologic cancers from member institutions. We present the Patient Annual Report for 2014 and the Treatment Annual Report for 2009. Data on 7436 patients with cervical cancer, 9673 with endometrial cancer, 5924 with ovarian cancer, and 1909 with ovarian borderline tumor for whom treatment was initiated in 2014 were summarized in the Patient Annual Report. Stage I accounted for 55.6%, stage II for 22.9%, stage III for 10.2%, and stage IV for 11.2% of all patients with cervical cancer. Stage I accounted for 72.3%, stage II for 6.0%, stage III for 14.1%, and stage IV for 7.7% of all patients with endometrial cancer. Stage I accounted for 43.3%, stage II for 9.1%, stage III for 27.6%, and stage IV for 7.2% of all patients with ovarian cancer. Data on the prognosis of 4126 patients with cervical cancer, 4613 with endometrial cancer, and 3205 with ovarian cancer for whom treatment was initiated in 2009 were analyzed in the Treatment Annual Report. Survival was analyzed by using the Kaplan–Meier method, the log–rank test and the Wilcoxon test. The 5‐year overall survival rates for patients with cervical cancer were 92.4% for stage I, 76.7% for stage II, 54.3% for stage III, and 25.2% for stage IV. The equivalent rates for patients with endometrial cancer were 94.6%, 89.4%, 78.3%, and 25.0%, respectively; and those for patients with ovarian cancer (surface epithelial–stromal tumors) were 90.5%, 78.8%, 46.0%, and 25.1%, respectively.