bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caregiving burden, social support, and psychological well-being among family caregivers of older Italians: a cross-sectional study
Authors: Bongelli Ramona , Busilacchi Gianluca , Pacifico Antonio , Fabiani Michele , Guarascio Carmela , Sofritti Federico , Lamura Giovanni , Santini Sara 
Published: October 2024

ObjectivesThis study aimed to identify factors affecting the psychological well-being of family caregivers of dependent older adults in Italy. Understanding these variables is essential for designing interventions to prevent negative outcomes in at-risk caregivers. The research explored how varying levels of caregiving burden and types of perceived social support influence psychological well-being.MethodsA cross-sectional study was conducted among 387 family caregivers of older adults in the Marche region (Italy) between November 2019 and March 2020. Data were collected via a structured questionnaire assessing psychological well-being (WHO-5 Well-Being Index), caregiving burden, and social support (COPE Index). Statistical analyses were performed using Jamovi software, with a significance threshold set at p &lt; 0.05.ResultsA significant negative correlation was found between caregiving burden and psychological well-being [r (364) = − 0.540, p &lt; 0.001], with caregiving burden being a significant predictor of psychological well-being reduction (R2 = 0.290; F = 150, p &lt; 0.001). A threshold value of 2 (on a 1–4 scale) was identified, where caregiving burden predicted a significant reduction in psychological well-being. Conversely, greater perceived social support was positively correlated with better psychological well-being [r (357) = 0.348, p &lt; 0.001] and was a significant predictor of it [R2 = 0.121; F = 49.2, p &lt; 0.001]. Support from social and health services had the most notable impact on psychological well-being. Moreover, social support mitigated the negative impact of caregiving burden on psychological well-being.ConclusionThe study confirms that high caregiving burden adversely affects caregivers’ psychological well-being, while social support plays a protective role. These findings highlight the need for interventions focused on reducing caregiving burden and enhancing support systems for family caregivers.
Healthcare Internet of Things system implementations for COVID-19 prevention
Authors: Leng Jichao , Lin Zihuai , Yoo Soojeong , Scandurra Gabriella , Dickinson Michael , Vucetic Branka , Wang Audrey P. 
Published: October 2024

BackgroundIn response to the widespread transmission of COVID-19 in Australia, healthcare facilities implemented stringent infection control measures, and mandatory and manual screening procedures were introduced to ensure the safety of patients and healthcare staff. However, these necessary measures resulted in imbalances within the healthcare system, a shortage of front-line workers and impacts on patient experience and wait times. The prioritization of infection control measures shifted resources away from routine care, causing delays in accessing necessary healthcare services.Methods and FindingsTo address these challenges, we developed and implemented an Internet of Things (IoT) Smart Screening eGate solution in partnership with a large metropolitan children’s hospital in Australia. This solution integrated a contactless health self-service web app, thermal camera, and physical barrier to automate the COVID-19 health screening and data recording process. During the 3-month pilot period, we deployed the eGate at multiple entrances to the hospital, and monitored the number of users of the system in different periods. We also used a framework of formative evaluation to classify user design challenges within limited resources and improved the design of the eGate to enhance its effectiveness. Our findings show that the IoT eGate solution improved the efficiency of the screening process and reduced the workload and exposure risks of front-line staff and anyone who required access to the hospital. By automating the screening process, we reduced the need for manual screening and minimized contact between individuals, thus reducing the risk of potentially infected.ConclusionIn conclusion, our pilot study demonstrated the potential of IoT technologies in improving the efficiency and safety of medical facilities during pandemics and provided a series of recommendations for the translation of IoT technologies for medical facilities, including the importance of co-design and collaboration with stakeholders, user-centered design, and ongoing monitoring and evaluation.
Responses of several measures to different intensity levels of upper limb exergames in children with neurological diagnoses: a pilot study
Authors: Goikoetxea-Sotelo Gaizka , van Hedel Hubertus J. A. 
Published: October 2024

BackgroundTherapy intensity is among the most critical factors influencing neurorehabilitative outcomes. Because of its simplicity, time spent in therapy is the most commonly used measure of therapy intensity. However, time spent in therapy is only a vague estimate of how hard a patient works during therapy. Several measures have been proposed to better capture the amount of work a patient puts forth during therapy. Still, it has never been analyzed how these measures respond to changes in therapist-selected exercise intensity in children with neurological conditions.ObjectivesTo investigate the response and the reliability of heart rate variability (HRV), skin conductance (SC), activity counts per minute (AC/min), movement repetitions per minute (MOV/min), and perceived exertion to different therapist-tailored intensity levels of upper limb technology-assisted therapy in children with neurological conditions.MethodsIn this pilot cross-sectional study, participants engaged in three personalized, randomized exergame intensity levels (“very easy”, “challenging”, “very difficult”) for eight minutes each. We assessed all measures at each intensity level. The experiment was conducted twice on two consecutive days. We quantified reliability using intra-class correlation coefficients (ICC).ResultsWe included 12 children and adolescents aged 11.92 (±3.03) years. HRV, MOV/min, and perceived exertion could differentiate among the three intensity levels. HRV, MOV/min, perceived exertion, and AC/min showed moderate to excellent (0.62 ≤ ICC ≤ 0.98) test-retest reliability.ConclusionHRV, MOV/min, and perceived exertion show potential for becoming valid and reliable intensity measures for an upper limb robotic rehabilitative setting. However, studies with larger sample sizes and more standardized approaches are needed to understand these measures’ responses better.
Application of additional dose of N could sustain rice yield and maintain plant nitrogen under elevated ozone (O3) and carbon dioxide (CO2) condition
Authors: Chakrabarti Bidisha , Sharma Sheetal , Mishra Ajay Kumar , Kannojiya Sudha , Kumar V. , Bandyopadhyay S. K. , Bhatia Arti 
Published: October 2024

IntroductionGlobal food security is challenged by the increasing levels of air pollutants like ozone (O3) through their impacts on crop productivity. The present study was conducted to quantify the interactive effect of elevated ozone (O3) and carbon dioxide (CO2), on different rice varieties in northern India.MethodsAn experiment was conducted in Genetic H field, Environment science, IARI for two consecutive years (2020 and 2021) during the kharif season, to quantify the impact of elevated O3 and CO2 interaction on productivity, and plant N in three rice varieties (Pusa basmati 1121, Nagina 22, IR64 Drt1) under different nitrogen (N) management practices. Rice crop was grown in Free Air Ozone-Carbon dioxide Enrichment rings (FAOCE) rings with two levels of O3 (elevated 60 ±10ppb and ambient) and two levels of CO2 (elevated, 550±25 ppm and ambient) concentration and their interaction with two N fertilizer treatments i.e., 100% RDN (recommended dose of N) and 125% RDN.Results and discussionElevated O3 significantly decreased physiological parameters like photosynthesis rate, stomatal conductance and transpiration rate of the crop. Grain yield reduced by 7.2-7.5%, in Pusa Basmati 1121 and from 6.9-9% in IR64 Drt1 varieties in elevated O3 treatment as compared to ambient treatment. Yield reduction in Nagina 22 variety was not significant in elevated O3 treatment. Elevated CO2 concentration of 550 ppm was able to fully compensate the yield loss in Nagina 22 variety and partially compensate (3.9-8.0%) in Pusa Basmati 1121 and IR64 Drt1 varieties. Grain N concentration in rice varieties decreased by 10.8-14.7% during first year and by 7.8-20.6% during second year in elevated O3 plus CO2 interaction treatment than ambient. Grain N uptake also decreased (13.2-17.1% in first year and 4.5-22.8% in second year) in elevated O3 plus CO2 interaction treatment as compared to ambient. Application of additional 25% of recommended dose of N improved grain N concentration, grain N uptake as well as available N of soil as compared to 100% RDN treatment in elevated O3 plus CO2 interaction treatment. Additional 25% N dose could help in sustaining rice productivity and quality under elevated O3 and CO2 condition.
Enhanced Age-Dependent Motor Impairment in Males of Drosophila melanogaster Modeling Spinocerebellar Ataxia Type 1 Is Linked to Dysregulation of a Matrix Metalloproteinase
Authors: Palmer Emma M. , Snoddy Caleb A. , York Peyton M. , Davis Sydney M. , Hunter Madelyn F. , Krishnan Natraj 
Published: October 2024

Over the past two decades, Drosophila melanogaster has proven to be successful in modeling the polyglutamine (polyQ) (caused by CAG repeats) family of neurodegenerative disorders, including the faithful recapitulation of pathological features such as polyQ length-dependent formation of protein aggregates and progressive neuronal degeneration. In this study, pan-neuronal expression of human Ataxin-1 with long polyQ repeat of 82 amino acids was driven using an elav-GAL4 driver line. This would essentially model the polyQ disease spinocerebellar ataxia type 1 (SCA1). Longevity and behavioral analysis of male flies expressing human Ataxin-1 revealed compromised lifespan and accelerated locomotor activity deficits both in diurnal activity and negative geotaxis response compared to control flies. Interestingly, this decline in motor response was coupled to an enhancement of matrix metalloproteinase 1 (dMMP1) expression together with declining expression of extracellular matrix (ECM) fibroblast growth factor (FGF) signaling by hedgehog (Hh) and branchless (bnl) and a significant decrease in expression of survival motor neuron gene (dsmn) in old (30 d) flies. Taken together, our results indicate a role for dysregulation of matrix metalloproteinase in polyQ disease with consequent impact on ECM signaling factors, as well as SMN at the neuromuscular junction causing overt physiological and behavioral deficits.
Identification of Key Enzymes and Genes Modulating L-Ascorbic Acid Metabolism During Fruit Development of Lycium chinense by Integrating Metabolome, Transcriptome, and Physiological Analysis
Authors: Yin Chongxin , Xie Huichun , Geng Guigong , Li Zuxia , Ma Jianxia , Wu Xiaozhuo , Qiu Quan-Sheng , Qiao Feng 
Published: October 2024

Lycium chinense is acknowledged for its substantial nutritional benefits, particularly attributed to the high levels of ascorbic acid (AsA) found in its fruits. The “Mengqi No.1” variety of L. chinense, which is cultivated in Qinghai, is known for its high yield and exceptional quality. We utilized the “Mengqi No.1” variety as experimental materials and combined metabolomic, transcriptomic, and physiological analyses to investigate the metabolites, genes, and enzymes related to AsA metabolism in L. chinense fruits. The results revealed nine differential metabolites associated with AsA metabolism in L. chinense fruits across three stages, including 1D-Myo-Inositol-1,4-Bisphosphate, D-Fructose, L-(+)-Arabinose, I-Inositol, L-Arabinitol, D-Galactose-1-P, lactose, α-D-Glucose, and D-Glucose-6-P. Notably, the contents of D-Glucose-6-P, D-Galactose-1-P, and D-Fructose were increased as the fruit developed. Additionally, fresh weight, longitudinal length, and radial width were increased, while the contents of AsA and DHA were decreased. GalDH and DHAR are critical enzymes for the accumulation of AsA and DHA, exhibiting positive correlation coefficient. Furthermore, PMM1, PMM5, GME2, and GME3 were identified as key regulatory genes in the L-Galactose pathway of AsA synthesis, influencing D-Galactose-1-P, D-Glucose-6-P, α-D-Glucose, and D-Fructose. DHAR1 and DHAR2 are considered key positive regulator genes of AsA and DHA in the AsA-GSH cycle. However, the majority of genes (nine) act as negative regulators of AsA and DHA. These findings provide a foundation for the understanding of the regulatory mechanism of AsA metabolism in L. chinense fruits and offer insights into the utilization of AsA from L. chinense.
Seeds Priming with Bio-Silver Nanoparticles Protects Pea (Pisum sativum L.) Seedlings Against Selected Fungal Pathogens
Authors: Stałanowska Karolina , Railean Viorica , Pomastowski Paweł , Pszczółkowska Agnieszka , Okorski Adam , Lahuta Lesław Bernard 
Published: October 2024

Nano-priming is a relatively new seed treatment technique using metal and metal oxide nanoparticles (NPs), and such application of NPs may support the plants’ immunity. Recently we have shown that the that biologically synthesized silver nanoparticles (bio-AgNPs) used as short-term foliar treatment protect pea seedlings against D. pinodes and F. avenaceum. In the present study, the protection of peas against both fungal pathogens via seed priming with bio-AgNPs was analyzed. Moreover, the changes in the polar metabolic profiles of the seedlings caused by priming and infection were also compared. Seed priming with bio-AgNPs at concentrations of 50 and 100 mg/L considerably reduced the symptoms and infection levels of both pathogens by over 70% and 90% for F. avenaceum and D. pinodes, respectively. Pathogens infection and nano-priming affected the metabolic profile of pea seedlings. The major changes in the primary metabolism were observed among carbohydrates and amino acids. In turn, this may result in changes in the expression and accumulation of secondary metabolites. Therefore, further investigation of the effect of nano-priming should focus on the changes in the secondary metabolism.
Transcriptional Modulation of Plant Defense Genes by a Bipartite Begomovirus Promotes the Performance of Its Whitefly Vector
Authors: He Wen-Ze , Liu Shu-Sheng , Pan Li-Long 
Published: October 2024

The majority of plant viruses rely on insect vectors for inter-plant transmission. Amid virus transmission, vector-borne viruses such as begomoviruses may significantly modulate host plants in various ways and, in turn, plant palatability to insect vectors. While many case studies on monopartite begomoviruses are available, bipartite begomoviruses are understudied. More importantly, detailed elucidation of the molecular mechanisms involved is limited. Here, we report the mechanisms by which an emerging bipartite begomovirus, the Sri Lankan cassava mosaic virus (SLCMV), modulates plant defenses against whitefly. SLCMV infection of tobacco (Nicotiana tabacum) plants significantly downregulated defenses against whitefly, as whitefly survival and fecundity increased significantly on virus-infected plants when compared to the controls. We then profiled SLCMV-induced transcriptomic changes in plants and identified a repertoire of differentially expressed genes (DEGs). GO enrichment analysis of DEGs demonstrated that the term defense response was significantly enriched. Functional analysis of DEGs associated with defense response revealed that four downregulated DEGs, including putative late blight resistance protein homolog R1B-17 (R1B-17), polygalacturonase inhibitor-like (PGI), serine/threonine protein kinase CDL1-like (CDL1), and Systemin B, directly contributed to plant defenses against whitefly. Taken together, our findings elucidate the role of novel plant factors involved in the modulation of plant defenses against whitefly by a bipartite begomovirus and shed new light on insect vector–virus–host plant tripartite interactions.
АНАЛИЗ ДИНАМИКИ РОССИЙСКОГО РЫНКА АКЦИЙ И ОСНОВНЫХ ФАКТОРОВ, ОКАЗАВШИХ ВЛИЯНИЕ НА ЕГО СТАНОВЛЕНИЕ С 2010 ПО 2023 ГОД
Authors: СМОЛИНА Е.С. , БЕРЕЖНАЯ В.А. 
Published: October 2024

Данная научная статья направлена на исследование динамики российского рынка акций и событий, существенно изменивших котировки долевых инструментов, в том числе комплексное рассмотрение количественных показателей состояния рынка акций. В работе проанализировано состояние сегмента финансового сектора Российской Федерации за последние тринадцать лет, включая влияние наиболее известных мировых событий пандемия коронавирусной инфекции COVID-19 и специальная военная операция. Цель исследования заключается в изучении динамических изменений рынка акций в Российской Федерации, вызванных опасными явлениями - мировым заболеванием и санкциями.
The article is aimed at studying the dynamics of the Russian stock market and events that significantly changed the quotations of equity instruments, including a comprehensive review of quantitative indicators of the stock market. The paper analyzes the state of the financial sector segment of the Russian Federation over the past thirteen years, including the impact of the most famous world events the COVID-19 coronavirus pandemic and a special military operation. The purpose of the study is to study the dynamic changes in the stock market in the Russian Federation caused by dangerous phenomena - global disease and sanctions.
ЗНАЧЕНИЕ МЕЖДУНАРОДНОГО ЛИЗИНГА ДЛЯ ЭКОНОМИКИ СТРАНЫ
Authors: БУДАРИНА Н.А. 
Published: October 2024

В статье представлены результаты исследования влияния международных лизинговых операций на развитие экономики страны. Определено, что международный лизинг представляет собой эффективный инструмент оптимизации расходов, который позволяет предприятиям достичь своих бизнес-целей с минимальными затратами. Доказано, что международный лизинг особенно важен в странах, где отечественные компании имеют ограниченный доступ к собственным средствам для производственных инвестиций и не имеют государственной поддержки. В этих условиях использование международного лизинга может оказать существенное положительное влияние на развитие различных отраслей промышленности и национальной экономики в целом.
The article presents the results of a study of the impact of international leasing operations on the development of the country's economy. It has been determined that international leasing is an effective cost optimization tool that allows enterprises to achieve their business goals with minimal costs. It has been proven that international leasing is especially important in countries where domestic companies have limited access to their own funds for production investments and do not have government support. Under these conditions, the use of international leasing can have a significant positive impact on the development of various industries and the national economy as a whole.
ТРАНСФОРМАЦИЯ БАНКОВСКОЙ ЭКОСИСТЕМЫ В КОНТЕКСТЕ ИЗМЕНЕНИЯ ТРУДОВЫХ НАВЫКОВ: ВЫЗОВЫ И СТРАТЕГИИ АДАПТАЦИИ
Authors: ИСМАИЛОВ С.С. 
Published: October 2024

В статье рассматриваются процессы цифровой трансформации банковской экосистемы и их влияние на изменение трудовых навыков. Рассматриваются методы управления изменениями, развитие цифровых талантов и важность всесторонней интеграции цифровых технологий в банковские процессы для повышения качества обслуживания клиентов, оптимизации операций и создания новых бизнес-моделей.
The article examines the processes of digital transformation within the banking ecosystem and their impact on changing labor skills. It discusses change management methods, the development of digital talents, and the importance of comprehensive integration of digital technologies into banking processes to enhance customer service quality, optimize operations, and create new business models.
ПРОТИВОДЕЙСТВИЕ ОТМЫВАНИЮ ДОХОДОВ, ПОЛУЧЕННЫХ ПРЕСТУПНЫХ ПУТЕМ, В СИСТЕМЕ ОБЕСПЕЧЕНИЯ ЭКОНОМИЧЕСКОЙ БЕЗОПАСНОСТИ ГОСУДАРСТВА
Authors: ТИМКОВ Н.А. 
Published: October 2024

В статье представлены результаты исследования сущности противодействия отмывания доходов, полученных преступным путем, в системе обеспечения экономической безопасности государства. Проведен анализ обширной теоретической и нормативной базы в области противодействия отмыванию доходов. Результаты исследования могут быть использованы в процессе совершенствования национальной системы противодействия отмыванию доходов.
The article presents the results of a study of the essence of countering the laundering of proceeds from crime in the system of ensuring the economic security of the state. The analysis of the extensive theoretical and regulatory framework in the field of combating money laundering has been carried out. The results of the study can be used in the process of improving the national anti-money laundering system.
ЭВОЛЮЦИЯ ФИНАНСОВОГО МОШЕННИЧЕСТВА С 90-Х ГОДОВ ДО НАШИХ ДНЕЙ
Authors: СМОЛИНА Е.С. , ЗАДОРОЖНЫЙ А.А. 
Published: October 2024

В данной статье рассмотрено развитие финансового мошенничества в России с 1990-х годов до настоящего времени. Определены понятие и признаки финансового мошенничества. Проанализирована динамика масштабов финансового мошенничества, его изменения и современные тенденции. Статья позволяет проследить, как мошенники адаптировали свои схемы к меняющимся социально-экономическим условиям и технологическим возможностям, что значительно усложнило борьбу с данным видом преступности и предопределяет необходимость постоянного повышения финансовой грамотности граждан.
This article examines the development of financial fraud in Russia from the 1990s to the present. The concept and signs of financial fraud are defined. The dynamics of the scale of financial fraud, its changes and current trends are analyzed. The article allows us to trace how fraudsters have adapted their schemes to changing socio-economic conditions and technological capabilities, which has significantly complicated the fight against this type of crime and determines the need for constant improvement of financial literacy of citizens.
ВЛИЯНИЕ МОНОПОЛИЗАЦИИ НА БЛАГОСОСТОЯНИЕ НАСЕЛЕНИЯ СОВРЕМЕННОГО РОССИЙСКОГО ОБЩЕСТВА
Authors: КАРИМОВА Л.Ф. , ТОЛСТОУХОВА Е.В. 
Published: October 2024

В данной статье рассмотрены теоретические аспекты монополизации. Представлены компании-монополисты в России, оказывающие существенное влияние на благосостояние населения современного общества. Проанализирована степень монополизации мирового рынка за период с 2019 по 2023 гг. Представлены пути государственного и международного антимонопольного регулирования современной мировой торговли.
This article discusses the theoretical aspects of monopolization. Monopoly companies in Russia are represented, which have a significant impact on the well-being of the population of modern society. The degree of monopolization of the world market for the period from 2019 to 2023 is analyzed. Ways of state and international antimonopoly regulation of modern world trade are presented.