bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel approach to derive human midbrain-specific organoids from neuroepithelial stem cells
Authors: Monzel Anna S. , Smits Lisa M. , Hemmer Kathrin , Hachi Siham , Lucumi Moreno Edinson , van Wuellen Thea , Fleming Ronan M.T. , Bolognin Silvia , Schwamborn Jebs C. 
Published: June 2016

AbstractResearch on human brain development and neurological diseases is limited by the lack of advanced experimentalin vitromodels that truly recapitulate the complexity of the human brain. Furthermore, animal models of human neurodegenerative diseases have failed dramatically, and the success rate of clinical trials based on these models has been disappointing. Here, we describe a novel and robust human brain organoid system that is highly specific to the midbrain derived from regionally patterned neuroepithelial stem cells. These human midbrain organoids contain spatially organized groups of dopaminergic neurons, which make them an attractive model to study Parkinson’s disease. Midbrain organoids are characterized in detail for neuronal, astroglial and oligodendrocyte differentiation. Furthermore, we show the presence of synaptic connections and electrophysiological activity. The complexity of this model is further highlighted by the myelination of neurites. The present midbrain organoid system has the potential to be used for advancedin vitrodisease modeling and therapy development.
CLARITY-compatible lipophilic dyes for electrode marking and neuronal tracing
Authors: Jensen Kristian H. R. , Berg Rune W. 
Published: June 2016

ABSTRACTFluorescent lipophilic dyes, such as DiI, stain cellular membranes and are used extensively for retrograde/anterograde labelling of neurons as well as for marking the position of extracellular electrodes after electrophysiology. Convenient histological clearing techniques, such as CLARITY, enable immunostaining and imaging of large volumes for 3D-reconstruction. However, such clearing works by removing lipids and, as an unintended consequence, also removes lipophilic dyes. To remedy this wash-out, the molecular structure of the dye can be altered to adhere to both membranes and proteins so the dye remains in the tissue after lipid-clearing. Nevertheless, the capacity of such modified dyes to remain in tissue has not yet been tested. Here, we test dyes with molecular modifications that make them aldehyde-fixable to proteins. We use three Dil-analogue dyes, CM-DiI, SP-DiI and FM 1-43FX that are modified to be CLARITY-compatible candidates. We use the challenging adult, myelin-rich spinal cord tissue, which requires prolonged lipid-clearing, of rats and mice. All three dyes remained in the tissue after lipid-clearing, but CM-DiI had the sharpest and FM 1-43FX the strongest fluorescent signal.
Agricultural productivity, credit and farm size nexus in Africa: a case study of Ghana
Authors: Akudugu Mamudu Abunga 
Published: June 2016

Purpose– The purpose of this paper is to examine the connections of agricultural productivity, access to credit and farm size in Africa using Ghana as a case study.Design/methodology/approach– The paper employs mixed methods – quantitative and qualitative strategies for data collection and analyses. The hierarchical competitive model was used for the quantitative analyses supplemented with qualitative analyses using key informant interviews, focus group discussions and household case studies.Findings– The results show that there is significant relationship between credit from formal and informal sources and agricultural productivity. Thus access to formal and informal credit increases farm household agricultural productivity by about 0.10 (p=0.05) and 0.45 (p< 0.01), respectively. The quadratic terms of formal and informal credit as well as farm size were found to significantly influence agricultural productivity. The implication of this is that the relationships between formal credit, informal credit and farm size on one hand and agricultural productivity on the other are non-linear in nature. The interactions of formal credit with informal credit; informal credit with farm size; and formal and informal credit with farm size have significant relationships with agricultural productivity. The amount of remittance received by farm households has negative and insignificant influence on agricultural productivity. Market access is also an insignificant determinant of agricultural productivity in Ghana.Originality/value– This paper provides new insights on whether the scale of production (farm size as proxy) and access to financial services (credit as a proxy) matter in promoting agricultural productivity in Africa using Ghana as a case study. Thus the paper is of relevance to policy-makers and practitioners in Africa and Ghana in particular who are seeking to make informed policy decisions on effectively incorporating credit provision into the agricultural transformation agenda of the continent.
Africa-based scholars publishing
Authors: Paulos Afeworki 
Published: June 2016

Purpose
The purpose of this paper is to discuss Africa-based scholars’ publication citation at the global level. The study selected four countries – Botswana, Nigeria, South Africa and Kenya.

Design/methodology/approach
The study analyzed citation data from Elsevier’s SciVal from 2010 to 2015.

Findings
The investigation reveals that Africa-based scholars in Botswana, South Africa and Kenya have a significant citation impact, particularly in the field of medicine.

Research limitations/implications
The study concentrated only on four African countries. International collaboration is an important factor and further investigation on this specific angle would be a useful research endeavor.

Practical implications
Influence university decision-making on funding for research; scholarly collaboration.

Originality/value
The study would be helpful in understanding the contribution of Africa-based scholars to knowledge creation and dissemination.
Understanding the grumbles
Authors: Crumpton Michael A. 
Published: June 2016

Purpose
This paper aims to advocate the consideration of Maslow’s Grumble Theory to advance motivational activities within the organization, as well as matching individual needs to morale concerns. This includes a view of associated costs as an investment instead of a common expense.

Design/methodology/approach
This paper includes a study of Maslow’s Needs Hierarchy and related literature that supports a modern interpretation. Suggestions are made for administrators to view solving complaints or grumbles proactively by investing in appropriate activities.

Findings
Overall, if complaints are viewed as opportunities to address individual needs, with the top level of grumbles empowered to help support high-level organizational functions, the organization can benefit greatly.

Originality/value
This paper represents the author’s point of view after a study of Grumble Theory and self-application of suggestions.
Implementation of power transformer controlled switching algorithm
Authors: Horiszny Jacek 
Published: June 2016

Purpose
– The paper presents two new algorithms of controlled switching the power transformer. The purpose of this paper is to obtain formulas that determine the moments of closing of the circuit breaker poles. The study contains projects of control systems for both algorithms.

Design/methodology/approach
– Mathematical formulas for the time instants of the breaker poles closing were developed on the basis of electric circuit theory and magnetic circuit theory. The presented systems were simulated using a model created in the Alternative Transients Program/Electromagnetic Transients Program software.

Findings
– Numerical simulations have proved that the shown systems properly perform the controlled switching carried out in accordance with the proposed algorithms. The times of the poles closing were correctly determined and the inrush currents were reduced to a level of the current of unloaded transformer.

Originality/value
– The results achieved are better than those shown in the literature. The solutions presented in the literature provide a reduction of inrush current to a value comparable to the rated current of the transformer, which is ten times greater than the no-load current. Additional achievement of the work is the development of analytical formulas that determine the times of the breaker poles closing.
Metamaterial-based wireless power transfer through interdigitated SRRs
Authors: Lalas Antonios X. , Kantartzis Nikolaos V. , Tsiboukis Theodoros D. 
Published: June 2016

Purpose– Wireless power transfer (WPT) is deemed as an emerging technology with exciting applications, like wireless charging devices, and electric vehicles, whereas metamaterials exhibit exceptional properties. For every WPT system that occupies coupled magnetic resonances, it is also mandatory to involve resonators. The purpose of this paper is to introduce a new interdigitated split-ring resonator (I-SRR) as the basic part of a WPT system, pursuing advanced levels of efficiency.Design/methodology/approach– A novel WPT system, which exploits I-SRRs as its elementary blocks, is comprehensively examined. The analysis investigates the distance between the modules, the distance between transmitting and receiving components as well as the geometrical features of the structure. Several numerical data derived via the finite element method unveil the merits of the featured configuration.Findings– The proposed arrangement reveals a noteworthy enhancement of the power delivered to the load and a promising tuning of the operational frequency via the interdigitated topology. Several parametric studies clarify the principal characteristics of the proposed setup, facilitating the design of high-end systems. In particular, the distance between the resonators and the port loops affect the matching of the input and output ports, allowing optimisation of power efficiency, while the length of the I-SRR gap can determine the operational frequency.Originality/value– Development of a WPT system, which utilises I-SRRs as its key elements. Incorporation of metamaterials into WPT technology. Efficiency enhancement of WPT systems and alternative design via geometrical modifications. The necessity of lumped elements to implement the WPT resonators is eliminated by utilising split-ring resonators components, enabling compactness in several implementations.
A precise electromagnetic field model useful for development of microwave imaging systems
Authors: Chaber Bartosz , Mohr Johan Jacob 
Published: June 2016

Purpose
– The paper describes a fast forward electromagnetic model built with help of commercial software. The purpose of this paper is to create an efficient and robust electromagnetic field model that could be easily plugged into a working microwave imaging system. The secondary purpose is to evaluate advantages and disadvantages of such a commercial packages for creating such a model.

Design/methodology/approach
– In this paper the authors decided to build the model using COMSOL Multiphysics software suite, ultimately comparing its result to measurements of a real device. The numerical model was created in an iterative fashion in order to determine how much details are needed to make it reliable, while keeping it efficient.

Findings
– The authors found that the commercial software seems like a viable platform for developing electromagnetic solvers. The resulting computer model is easy to prepare, run and integrate with external tools.

Research limitations/implications
– Using the experience in building numerical models of various systems the authors came to the conclusion that developing some in-house code is a very non-efficient technique as it slows down the progress of the research team once the team changes. Transfer of knowledge associated with the numerical tools is much easier when the tools are constructed using a common platform, i.e. commercial packages. It does not really matter if the software is free or proprietary as long as the platform provides efficient tools assisting in model preparation and data visualization.

Practical implications
– One of the main advantages of using such a full field electromagnetic model is the ability to investigate an impact of different properties of the system (length of antennas, liquid parameters) on its performance. Thanks to the use of commercial software it is much easier to pass the project to new people too.

Originality/value
– The presented numerical model utilizes a frugal meshing scheme which allows faster execution while keeping required accuracy of solutions. Using this model the authors were able to diagnose important geometrical details that could affect the performance of the system.
Which sport sponsorships most impact sponsor CSR image?
Authors: Plewa Carolin , Carrillat François Anthony , Mazodier Marc , Quester Pascale G. 
Published: June 2016

Purpose
This study aims to investigate how organizations can utilize sport sponsorship to build their corporate social responsibility (CSR) image effectively, by examining the attributes of a sports property that are most conducive to a sponsor gaining CSR image benefits.

Design/methodology/approach
A between-subjects experimental design was used, which simulated different sponsorship scenarios by varying community proximity (operationalized by property scope) and property engagement in community initiatives. Hypotheses were tested with a non-parametric bootstrapping-based procedure, using a panel sample of 400.

Findings
The results show that a sporting property’s proactive community engagement is conducive to an enhanced CSR image for its sponsor, especially when the property operates on the national rather than grassroots level. Further analysis also demonstrates the critical contribution of altruistic motive attributions in the process.

Originality/value
This study advances knowledge on how organizations may build their CSR image while leveraging on the strong audience involvement and the mass appeal of sport sponsorship. It is the first to offer insights into the extent to which a sports property’s proactive engagement in the community, rather than that of the sponsoring firm itself, enhances the CSR image of the sponsor, particularly if the property’s community proximity is low. Furthermore, our results provide an in-depth understanding of the mechanisms determining the benefits that sponsors can reap from a property’s activities.
Effects of task complexity on creative customer behavior
Authors: Gong Taeshik , Choi Jin Nam 
Published: June 2016

PurposeImproving the creative performance of customers is critical to improving the competitive advantage of service firms. Customers that perform creatively and generate novel and useful ideas contribute to firm profitability by helping the firm save on costs and improve its services rather than merely relying on its employees. This paper aims to focus on creative customer behavior and examine its antecedents.Design/methodology/approachThe analysis is based on a dyadic data set involving salespeople and their customers, collected over two periods across various industries in the context of business-to-business service deliveries.FindingsResults indicate that customer task complexity affects creative customer behavior not through intrinsic motivation but through customer stress, and reveal that customer learning orientation and customer creative ability positively moderate these relationships.Originality/valueCustomers, salespeople and their managers should enrich the customers’ tasks with core job characteristics, in particular significance and feedback, and treat task stress as a positive, surmountable challenge that facilitates customer value creation. The results also indicate that to enhance creative customer behavior, managers should appreciate and develop customers’ learning orientation and creative ability, which in turn leads to increased sales performance and service quality.
Consumers’ pre-launch awareness and preference on movie sales
Authors: Moon Sangkil , Kim Junhee , Bayus Barry L. , Yi Youjae 
Published: June 2016

Purpose
The purpose of this paper is to provide insightful advice that can improve the practice of using consumers’ pre-launch awareness and preference (AP) changes to predict the sales of new movies.

Design/methodology/approach
This paper applies a new movie box-office revenue forecasting model based on consumers’ weekly AP measures, to take advantage of the industry’s practice of using weekly survey data containing the AP measures of upcoming new movies. Specifically, a sales forecasting model is developed on the basis of the theory that the combination of the nature of new product preference (positive vs negative) and the timing of new product awareness (early vs recent) influences entertainment product sales.

Findings
This paper shows that early awareness consumers are as important as late awareness consumers in determining new product sales, suggesting that more marketing resources need to be allocated earlier than currently practiced. This paper also shows that when negative preferences dominate positive preferences well ahead of a product’s release, marketing efforts cannot overcome the negative sentiment of the market. Finally, the empirical application illustrates that three consumer segments varying in product expertise and consumption frequency reveal different AP patterns among high-, medium- and low-performance products.

Originality/value
This paper is intended to provide insightful advice that can improve the AP-based approach in entertainment industries. Toward that end, the authors emphasize two major aspects in association with new entertainment product sales: rethinking survey-based AP measures and examining heterogeneous consumer segments’ differential AP patterns.
Science, technology and innovation systems of small economies under pressure – sketching three possible future pathways of the Finnish system
Authors: Nieminen Mika , Loikkanen Torsti , Pelkonen Antti 
Published: June 2016

Purpose
The purpose of this paper is to explore and discuss possible future pathways of the Finnish science, technology and innovation (STI) system. The paper sketches three speculative pathways for the Finnish STI system.

Design/methodology/approach
Theoretical considerations behind the pathways are based on analyses of the determinants and behaviour of small open economies, their innovation systems and governance. The empirical background of the paper is in the current trends of the Finnish economy and STI system. The analysis of pathways is based on three dimensions: institutionalized policy environment and economy, domestic interest groups and policy and STI institutions and funding. Changes in these dimensions are analysed by paying special attention to two variables: the position of the nation state and the general economic development.

Findings
The first future pathway outlined is based on an optimistic view by setting Finland on the basis of past success factors as an European and global STI hotspot. The second pathway is based on the assumption that the Finnish STI system will be increasingly subordinated to international structures and decision-making. The third one is geared around the assumption that the Finnish STI system will be dominated by industries.

Research limitations/implications
While Finland has been seen as a European showpiece of innovation since the early 2000s, currently the country’s national economy and STI system are undergoing a critical period. The paper sheds light on this transformation and its potential future outcomes and attempts to raise debate on the options policy makers may face in the increasingly complex global environment in small countries.

Originality/value
The paper introduces potential future avenues for the Finnish STI system and provides a contribution to the debate of the future of small countries’ STI systems and innovation policies by emphasising the limited space of the STI policy choices and how the development paths and space for policy making evolve from the interaction of socio-economic factors between domestic and wider international context.
Strategies for emerging research and innovation futures
Authors: Amanatidou Effie , Saritas Ozcan , Loveridge Denis 
Published: June 2016

Purpose
This paper aims to present a set of strategic options for Research and Innovation (R&I) stakeholders in the light of new and emerging ways of organising and performing research.

Design/methodology/approach
The paper first reviews the evolution of the R&I landscape and identifies the most influential stakeholders engaged in R&I. In the light of the scenarios developed for the year 2030, a set of strategic options are identified and assessed for each stakeholder group.

Findings
R&I systems are now more complex than 50 years ago and will be even more in the future. Radical changes are expected in terms of the ways research is funded, organised and carried out. Some of these transformations are captured by the scenarios developed. The analysis of scenarios indicated that their feasibility and desirability differ across different sectors of industry, and research areas within the research landscape.

Research limitations/implications
Scenarios and strategies presented in the paper bring new considerations on the way research activities are practiced. Further research is considered to be useful on the new modes of research and implications for academia, industry, society and policy makers.

Practical implications
The discussion around the responses of different stakeholders vis-à-vis specific scenarios about the future in R&I practices and organisation gives a practical view about how to deal with associated emerging trends and issues.

Social implications
Society is a crucial stakeholder of all R&I activities. The transformative scenarios suggest that society will not only be playing a reactive role on the demand side but also more proactive role on the supply side in the decades to come.

Originality/value
The paper is based on work undertaken within the Research and Innovation (RIF) 2030 project. As R&I activities will be important for the development and competitiveness of the EU and its member states, the work presented here is considered to be of value by highlighting how to create more resilient strategies in a fast-changing R&I landscape.
New forms of innovation: critical issues for future pathways
Authors: Leitner Karl-Heinz , Warnke Philine , Rhomberg Wolfram 
Published: June 2016

Purpose
Although new forms of innovation such as open innovation, user innovation or crowdsourcing have been intensively discussed in the past decade, there is little systematic exploration of their wider positive and negative effects on economy, society and environment. Based on the recent debate in the literature and findings from a European foresight project, this paper aims to discuss the critical aspects of new forms of innovation such as increased participation, the use of information technologies and the increased pace of innovation and their challenges for innovation policy.

Design/methodology/approach
Based on a collection of international practice examples from industry and society, innovation visions have been generated and assessed by different experts across whole Europe.

Findings
A generic trend identified can be best described as open, distributed and networked innovation process. Although many new innovation models accelerate the innovation process, there are also some counter trends which in some fields may slow down the innovation process. In addition, the increased use of web-based tools, algorithms and information technologies raises new questions concerning the protection of intellectual property and data security. This reveals new questions for policymaking, which have not gained much attention on the European level so far.

Originality/value
Although there is an established discourse around potentially negative impacts of the outcomes of the innovation processes notably in the field of technology assessment, innovation capacity is usually seen as a desirable characteristic of innovation systems. In this paper, the possible negative aspects of new innovation models, an issue hardly addressed in the innovation literature so far, are discussed.