bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced Nociception in Angelman Syndrome Model Mice
Authors: McCoy Eric S. , Taylor-Blake Bonnie , Aita Megumi , Simon Jeremy M. , Philpot Benjamin D. , Zylka Mark J. 
Published: September 2017

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by mutation or deletion of the maternalUBE3Aallele. The maternalUBE3Aallele is expressed in nearly all neurons of the brain and spinal cord, whereas the paternalUBE3Aallele is repressed by an extremely long antisense transcript (UBE3A-ATS). Little is known about expression ofUBE3Ain the peripheral nervous system, where loss of maternalUBE3Amight contribute to AS phenotypes. Here we sought to examine maternal and paternalUbe3aexpression in DRGs neurons and to evaluate whether nociceptive responses were affected in AS model mice (global deletion of maternalUbe3aallele;Ube3am−/p+). We found that most large-diameter proprioceptive and mechanosensitive DRG neurons expressed maternalUbe3aand paternalUbe3a-ATS. In contrast, most small-diameter neurons expressedUbe3abiallelically and had low to undetectable levels ofUbe3a-ATS. Analysis of single-cell DRG transcriptomes further suggested thatUbe3ais expressed monoallelically in myelinated large-diameter neurons and biallelically in unmyelinated small-diameter neurons. Behavioral responses to some noxious thermal and mechanical stimuli were enhanced in male and female AS model mice; however, nociceptive responses were not altered by the conditional deletion of maternalUbe3ain the DRG. These data suggest that the enhanced nociceptive responses in AS model mice are due to loss of maternalUbe3ain the central, but not peripheral, nervous system. Our study provides new insights into sensory processing deficits associated with AS.SIGNIFICANCE STATEMENTAngelman syndrome (AS) is a neurodevelopmental disorder caused by loss or mutation of the maternalUBE3Aallele. While sensory processing deficits are frequently associated with AS, it is currently unknown whetherUbe3ais expressed in peripheral sensory neurons or whether maternal deletion ofUbe3aaffects somatosensory responses. Here, we found thatUbe3ais primarily expressed from the maternally inherited allele in myelinated large-diameter sensory neurons and biallelically expressed in unmyelinated small-diameter neurons. Nociceptive responses to select noxious thermal and mechanical stimuli were enhanced following global, but not sensory neuron-specific, deletion of maternalUbe3ain mice. These data suggest that maternal loss ofUbe3aaffects nociception via a central, but not peripheral mechanism, with implications for AS.
Sublaminar Subdivision of Mouse Auditory Cortex Layer 2/3 Based on Functional Translaminar Connections
Authors: Meng Xiangying , Winkowski Daniel E. , Kao Joseph P.Y. , Kanold Patrick O. 
Published: September 2017

The cerebral cortex is subdivided into six layers based on morphological features. The supragranular layers 2/3 (L2/3) contain morphologically and genetically diverse populations of neurons, suggesting the existence of discrete classes of cells. In primates and carnivores L2/3 can be subdivided morphologically, but cytoarchitectonic divisions are less clear in rodents. Nevertheless, discrete classes of cells could exist based on their computational requirement, which might be linked to their associated functional microcircuits. Throughin vitroslice recordings coupled with laser-scanning photostimulation we investigated whether L2/3 of male mouse auditory cortex contains discrete subpopulations of cells with specific functional microcircuits. We use hierarchical clustering on the laminar connection patterns to reveal the existence of multiple distinct classes of L2/3 neurons. The classes of L2/3 neurons are distinguished by the pattern of their laminar and columnar inputs from within A1 and their location within L2/3. Cells in superficial L2 show more extensive columnar integration than deeper L3 cells. Moreover, L3 cells receive more translaminar input from L4.In vivoimaging in awake mice revealed that L2 cells had higher bandwidth than L3 cells, consistent with the laminar differences in columnar integration. These results suggest that similar to higher mammals, rodent L2/3 is not a homogenous layer but contains several parallel microcircuits.SIGNIFICANCE STATEMENTLayer 2/3 of auditory cortex is functionally diverse. We investigated whether L2/3 cells form classes based on their functional connectivity. We usedin vitrowhole-cell patch-clamp recordings with laser-scanning photostimulation and performed unsupervised clustering on the resulting excitatory and inhibitory connection patterns. Cells within each class were located in different sublaminae. Superficial cells showed wider integration along the tonotopic axis and the amount of L4 input varied with sublaminar location. To identify whether sensory responses varied with sublaminar location, we performedin vivoCa2+imaging and found that L2 cells were less frequency-selective than L3 cells. Our results show that the diversity of receptive fields in L2/3 is likely due to diversity in the underlying functional circuits.
Mundo Amazónico es ahora una revista colombo-brasileña
Authors: Mundo Amazónico Revista 
Published: September 2017

Hasta el año 2016, Mundo Amazónico fue editada por el Instituto Imani de la Universidad Nacional de Colombia, con sede en Leticia (Amazonas, Colombia). A partir de 2017, la revista será editada en conjunto con el Programa de Pós-Graduação em Antropologia Social (PPGAS) de la Universidade Federal do Amazonas (UFAM), con sede en Manaus (Brasil). Los profesores Gilton Mendes dos Santos y Carlos Machado Dias Jr., coordinadores del PPGAS son ahora miembros del Comité Editorial de la revista, junto con los profesores Germán Palacio y Juan A. Echeverri, del Instituto Imani, y Luisa Belaunde (UFRJ) y Carlos Rodríguez (Tropenbos-Colombia) como miembros externos.
Three Halves of a Whole – Redefining East and West in UNESCO’s East-West Major Project 1957-1966
Authors: Huttunen Miia 
Published: September 2017

In 1946 Julian Huxley, UNESCO’s rst Director-General, suggested that two opposing philosophies of life were confronting each other from the East and the West, setting the focus on the cultural aspect of this polarisation and de ning the possibility of an East- West conflict as the main threat to world peace. A decade later, in 1957, UNESCO launched The Major Project on the Mutual Appreciation of Eastern and Western Cultural Values to promote its ideas of intercultural understanding as a means to maintaining peace. The core concepts of the Project, East and West, were not strictly defined. Here East and West, as concepts, fit Reinhart Koselleck’s definition of Grundbegriffe, or basic concept – something which by nature is complex, controversial, ambiguous and contested, but also indispensable. The purpose of this article is to trace the evolution of the concepts during the ten years of the Project. The concepts are analysed with the tools of conceptual history and contextualised primarily in a cultural framework. An analysis of the concepts reveals that East and West were, at first, referred to as two opposing elements that could only be understood in relation to each other, leading to a binary opposition. This original depiction developed into the recognition of several civilisations existing within and outside the East-West dichotomy and thus to an ongoing discussion of the nature of intercultural relations within the UNESCO context. The conceptual transformation reflects UNESCO’s evolution from an essentially Western European organisation to a forum of intercultural dialogue of a truly worldwide nature. This article suggests an alternative understanding of international cultural relations of the 1950s and 1960s outside both the Cold War and post-colonial frameworks.
Keywords: UNESCO, East, West, cultural conflict, conflict prevention
Esittävän taiteen vapaa kenttä osana muuttuvaa kolmatta sektoria
Authors: Oinaala Anu , Ruokolainen Vilja 
Published: September 2017

Independent Performing Arts Sector as a Part of the Third Sector inTransition
This article examines the Finnish independent performing arts sector as a part of the so-called third (non-profit and voluntary) sector. The independent performing arts sector is analyzed from the viewpoint of the changing nature of the new third sector as identified in recent research. The aim of the article is to describe the agents in the manifold independent sector of performing arts and to analyze what kind of forms the elements important to the so-called new third sector, organizational membership and paid labour, take in the independent performing arts. From the genres of performing arts, theatre, dance, circus and performance art are investigated. There are two sets of data. Quantitative data consists of the number of productions performed in the Helsinki region during 2009–2011 by the independent performing arts sector and the number of the artists participating in those productions. The qualitative data includes case studies from 16 independent performing arts groups from around Finland. In addition to case studies, research methods include typification and network analysis. This article is concerned especially with four identified transitions in the third sector: from volunteerism to professionalism, from institutions to informal groups, from influencing to performing services and from traditional membership to different forms of participation. We conclude that the independent sector in the performing arts consists of a variety of forms of organization, and the volume of productions by groups that are not formally organized is significant. Membership has several different meanings, and they often differ from the traditional notion of the concept. In the independent sector of the arts different forms of employment and labour are mixed. The independent performing arts sector uses many familiar third sector features such as forms of organization, tradition of volunteering and light administration to organize and fund its activities, but it also moves freely outside the third sector conventions, borrows and creates its own ways, which are sometimes again borrowed by actors outside the arts sector.
Keywords: Independent arts sector, performing arts, third sector
THE MORBIDITY WITH TEMPORARY DISABILITY OF WORKING MILITARY RETIREES
Authors: Popov A. V. 
Published: September 2017

The purpose of the study. The study of morbidity with temporary disability of working officers of the Navy, retired and resigned, as well as affecting the level of certain factors.Materials and methods. A sociological survey of 574 officers of the Navy, who were dismissed from the Armed Forces to the reserve (resignation), was held. 32.7% of them at the time of the survey have been working.Results. 48.8% of respondents rated their health at the time of the survey as a good for their age. The level of morbidity with temporary disability (MWTD) in 100 operating reserve (retired) officers amounted to 94 cases. The number of days of temporary disability was equal to 867 days per 100 employed military pensioners. Most long-term treatment (up to 47 days) were required for patients with blood diseases. Analysis of the structure of diseases of reserve (retired) officers leading to temporary disability, showed that the bulk of the cases (63.7 per cent) were diseases of the respiratory organs, in second place were diseases of the circulatory system (24,5%), the third — diseases of the genitourinary system (4.3%). The average number of existing diseases to working military retirees less than idle: 1.9 vs 2.1. The average number of diseases at the single soldiers discharged was significantly more than that of living in family.Conclusion. The features of level and structure, as well as risk factors of MWTD should be considered in the development and adoption of administrative decisions directed on preservation and strengthening of health of reserve (retired) officers.
Brasília nos filmes da Novacap
Authors: Gomes Ana Lúcia de Abreu 
Published: September 2017

Com este artigo, pretende-se apresentar uma possibilidade de leitura dos cinejornais produzidos durante a construção de Brasília e as implicações desse exercício de leitura para construção da imagem da capital brasileira em seus anos subsequentes. Por meio da análise dos filmes – que contaram com apoio do Estado pelo Decreto 21.240 de 1932 –, o texto leva a refletir sobre o processo político de construção de uma capital moderna para o Brasil. As abordagens teórico-metodológicas, no que se refere ao uso de imagens como fontes para a construção do conhecimento histórico, indicam a importância de dar a conhecer os processos que geraram determinado conjunto documental.
Entre a crítica, o público e o autor: construção de sentido e crítica social em Brave New World de Aldous Huxley
Authors: Francisco Rafael da Cunha Duarte 
Published: September 2017

Esse trabalho tem como principal objetivo discutir o projeto estético criado por Aldous Huxley em seus romances distópicos, especialmente em "Brave New World", primeiramente publicado em 1932. A partir da comparação com alguns outros romances distópicos do mesmo período, pretendemos demonstrar como parece haver na obra de Huxley um projeto estético que se situa entre a crítica especializada, seu público e a representação de si mesmo como alguém apto a prognosticar o futuro por meio de seu romance. Ao abordarmos a questão da morte no interior da trama ficcional, pretendemos apresentar ao leitor como esse prognóstico tenta validar-se, com mais ou menos sucesso, diante de seu público como o futuro a ser encarado pelos homens e mulheres das próximas gerações.
As audiografias: uma conversa histórica através dos sons
Authors: Corrêa Luiz Otávio 
Published: September 2017

Este artigo pretende apresentar o que se chama de Audiografias, escritas históricas produzidas a partir da linguagem radiofônica. Para explicar melhor a proposta, foi necessário relacionar a História Pública, ponto de partida desta experiência, ao paradigma relacional da comunicação. Finalmente, é apresentada uma primeira produção chamada “O Rádio e o poder nos anos 30”, bem como a página Paisagens Históricas, espaço para a distribuição e para as interações realizadas pelo programa produzido.
Biodiversitas Belalang (Acrididae : Ordo Orthoptera) pada Agroekosistem (Zea mays L.) dan Ekosistem Hutan Tanaman
Authors: Prakoso Bagas 
Published: September 2017

Penelitian ini bertujuan untuk mengetahui keanekaragaman belalang (Acrididae: Ordo Orthoptera) pada agroekosistem (Zea mays L.) dan ekosistem hutan tanaman serta menentukan peran belalang pada kedua ekosistem. Penelitian ini dilakukan dengan metode survai lapangan. Parameter yang diamati pada setiap lokasi meliputi keanekaragaman vegetasi tumbuhan, pengumpulan belalang Acrididae ordo Orthoptera dan pengamatan langsung terhadap belalang Acrididae ordo Orthoptera. Keanekaragaman belalang yang ditemukan pada ekosistem dianalisis dengan indeks keanekaragaman meliputi: indeks keanekaragaman (H’), kemerataan (E) dan indeks kesamaan sorensen (C) serta analisis korelasi dan regresi. Sampel diambil dari agroekosistem (Zea mays L.) dan ekosistem hutan tanaman yang selanjutnya diulang sebanyak empat kali. Penelitian dilakukan pada bulan April s/d Juli 2014. Hasil penelitian ini ditemukan sebanyak 3.097 individu Orthoptera yang termasuk dalam Famili Tetrigidae, Acrididae dan Pyrgomorphidae yang terdiri dari 7 genus yaitu Atractomorpha, Criotettix, Gesunola, Hesperotettix, Miramella, Oxya, dan Valanga dengan 7 spesies. Pada agroekosistem ditemukan 3 spesies dengan 1.030 individu sedangkan pada hutan tanaman ditemukan 5 spesies dengan 2.067 individu. Hasil nilai indeks keanekaragaman Shannon-Weinner pada ekosistem hutan tanaman nilai keanekaragamannya lebih tinggi (0,6307) jika dibandingkan dengan agroekosistem (0,5325). Berdasarkan hal tersebut maka ekosistem hutan tanaman memiliki biodiversitas belalang yang lebih tinggi daripada agroekosistem (Zea mays L.).
Special Issue on Cutting Edge of Reinforcement Learning and its Hybrid Methods
Authors: Takadama Keiki , Miyazaki Kazuteru 
Published: September 2017

Machine learning has been attracting significant attention again since the potential of deep learning was recognized. Not only has machine learning been improved, but it has also been integrated with “reinforcement learning,” revealing other potential applications, e.g., deep Q-networks (DQN) and AlphaGO proposed by Google DeepMind. It is against this background that this special issue, “Cutting Edge of Reinforcement Learning and its Hybrid Methods,” focuses on both reinforcement learning and its hybrid methods, including reinforcement learning with deep learning or evolutionary computation, to explore new potentials of reinforcement learning.Of the many contributions received, we finally selected 13 works for publication. The first three propose hybrids of deep learning and reinforcement learning for single agent environments, which include the latest research results in the areas of convolutional neural networks and DQN. The fourth through seventh works are related to the Learning Classifier System, which integrates evolutionary computation and reinforcement learning to develop the rule discovery mechanism. The eighth and ninth works address problems related to goal design or the reward, an issue that is particularly important to the application of reinforcement learning. The last four contributions deal with multiagent environments.These works cover a wide range of studies, from the expansion of techniques incorporating simultaneous learning to applications in multiagent environments. All works are on the cutting edge of reinforcement learning and its hybrid methods. We hope that this special issue constitutes a large contribution to the development of the reinforcement learning field.
Reinforcement Learning Approach for Adaptive Negotiation-Rules Acquisition in AGV Transportation Systems
Authors: Nagayoshi Masato , Elderton Simon J. H. , Sakakibara Kazutoshi , Tamaki Hisashi ,   Niigata College of Nursing 240 Shinnan-cho, Joetsu, Niigata 943-0147, Japan,   Toyama Prefectural University 5180 Kurokawa, Imizu, Toyama 939-0398, Japan,   Kobe University 1-1 Rokkodai-cho, Nada-ku, Kobe, Hyogo 657-8501, Japan
Published: September 2017

In this paper, we introduce an autonomous decentralized method for directing multiple automated guided vehicles (AGVs) in response to uncertain delivery requests.	The transportation route plans of AGVs are expected to minimize the transportation time while preventing collisions between the AGVs in the system.	In this method, each AGV as an agent computes its	transportation route by referring to the static path information.	If potential collisions are detected, one of the two agents chosen by a	negotiation-rule modifies its route plan.	Here, we propose a reinforcement learning approach for improving the negotiation-rules.	Then, we confirm the effectiveness of the proposed approach	based on the results of computational experiments.
A Social Network Analysis of the Financial Links Backing Health and Fitness Apps
Authors: Grundy Quinn , Held Fabian , Bero Lisa 
Published: September 2017

Objectives. To identify the major stakeholders in mobile health app development and to describe their financial relationships using social network analysis. Methods. We conducted a structured content analysis of a purposive sample of prominent health and fitness apps available in November 2015 in the United States, Canada, and Australia. We conducted a social network analysis of apps’ developers, investors, other funding sources, and content advisors to describe the financial relationships underpinning health app development. Results. Prominent health and fitness apps are largely developed by private companies based in North America, with an average of 4.7 (SD = 5.5) financial relations, including founders, external investors, acquiring companies, and commercial partnerships. Network analysis revealed a core of 41 sampled apps connected to 415 other entities by 466 financial relations. This core largely comprised apps published by major technology, pharmaceutical, and fashion corporations. About one third of apps named advisors, many of whom had commercial affiliations. Conclusions. Public health needs to extend its scrutiny and advocacy beyond the health messages contained within apps to understanding commercial influences on health and, when necessary, challenging them.
Development of a Statewide, Publicly Accessible Drug Overdose Surveillance and Information System
Authors: Marshall Brandon D. L. , Yedinak Jesse L. , Goyer Jonathan , Green Traci C. , Koziol Jennifer A. , Alexander-Scott Nicole 
Published: September 2017

In response to Rhode Island’s overdose epidemic, we developed a collaborative, statewide online “dashboard” to provide the public with timely overdose surveillance data. The Web site— www.PreventOverdoseRI.org (PORI)—offers user-friendly data visualizations, plain language education, and interactive resource maps. Development of the site has improved overdose data sharing and transparency in Rhode Island. Preliminary results suggest a successful site launch. Future research will evaluate the effectiveness of PORI in terms of informing strategic initiatives to reduce overdoses in affected communities.
Legacies of 1917 in Contemporary Russian Public Health: Addiction, HIV, and Abortion
Authors: Rivkin-Fish Michele 
Published: September 2017

I examine the legacies of Soviet public health policy and the socialist health care system and trace how the Soviet past figures in contemporary Russian policymaking and debates about drug use, HIV, and abortion. Drug policies and mainstream views of HIV reflect continuities with key aspects of Soviet-era policies, although political leaders do not acknowledge these continuities in justifying their policies. In abortion policy, by contrast, which is highly debated in the public realm, advocates represent themselves as differing from Soviet-era policies to justify their positions. Yet abortion activists’ views of the past differ tremendously, reminding us that the Soviet past is symbolically productive for arguments about Russia’s present and future. I describe key aspects of the Soviet approach to health and compare how current drug policy (and the related management of HIV/AIDS) and abortion policies are discursively shaped in relation to the Soviet historical and cultural legacy.