bluuebunny/crossref_metadata_2025_split huggingface dataset:
Denying Corporate Rights and Punishing Corporate Wrongs
Authors: Sepinwall Amy J. 
Published: November 2015

ABSTRACT:
Scholars addressing the moral status of corporations are motivated by a pair of conflicting anxieties: If corporations are not moral agents, we will be unable to blame them for their wrongs. But if corporations are moral agents, we will have to recognize corporate moral rights, and the legal rights that flow therefrom. In early and under-appreciated work, Tom Donaldson sought to allay both concerns at once: Corporations, he argued, are not moral persons, and so are not eligible for many of the rights that persons enjoy; but they are moral agents, and so ought to bear responsibility in many of the ways that persons do. This article offers a sympathetic critique of the Donaldsonian strategy. I argue that, as it has been elaborated, the strategy necessarily fails. Nonetheless the strategy embodies a worthy aim and so I seek to provide an alternative way to vindicate it.
The 1996 Research Assessment Exercise in British universities: views from the judging and the judged
Authors: Cunliffe Barry , Harding Anthony , Austin David 
Published: November 2015

ANTIQUITY invited a member of the Research Assessment panel for archaeology in British universities to write about the exercise. He declined; as the matter was sub judice, he must be silent. Perhaps that phrase defines the colleague as judge, rather than as peer-reviewer.Fortunately, Barry Cunliffe, chairman of the archaeology review panel (and of ANTIQUITY'S trustees), made public his views in his Presidential Anniversary Address to the Society of Antiquaries of April 1995 —before the current assessment got under way. We reprint it with permission. Professor Cunliffe starts with a brisk reminder—overlooked by our coverage in the March ANTIQUITY—of the real benefits of asking just what researchers do for their money in the supposedly tranquil and desirable échelons of our universities.
‘Always momentary, fluid and flexible’: towards a reflexive excavation methodology
Authors: Hodder Ian 
Published: November 2015

Çatalhöyük, on the Konya Plain in south central Anatolia, in the 1960s became the most celebrated Neolithic site of western Asia: huge (21 hectares), with early dates, tightpacked rooms with roof access, exuberant mural paintings, cattle heads fixed to walls, dead buried beneath floors in collective graves.This site, as difficult to excavcate as it is strange, is the object of a pioneering application of the ‘post-processual’ approach, hitherto largely a matter of re-working and criticism outside the trench. The Çatalhöyük project director explains his approach, in which the conclusions as well as the work in early progress will be ‘always momentary, fluid and flexible’.
Cognitive, linguistic, and contextual factors in Norwegian second language learner's narrative production
Authors: KARLSEN JANNICKE , GEVA ESTHER , LYSTER SOLVEIG-ALMA 
Published: November 2015

ABSTRACTThe present study investigated the contribution of cognitive, linguistic, and contextual factors to the narrative production of Norwegian second language learners. We assessed cognitive ability and first and second language proficiency in 66 kindergarten children with Urdu/Punjabi as their first language. Number of children's books in the home and time spent in kindergarten were treated as contextual factors. Oral narration was assessed in Grade 1. A series of fixed-order hierarchical regression analyses displayed a complex relationship among cognitive, linguistic, and contextual factors and various facets of narrative production of young second language learners; nonverbal ability and books in the home predicted the mastering of story (macro)structure, while linguistic (vocabulary and grammar) and both contextual variables predicted microaspects of narrative proficiency. The results suggest that combining home book reading practices, kindergarten attendance, and second language interventions might improve language minority children's narrative production and chances of school success.
Back to the garden again: Joni Mitchell's ‘Woodstock’ and utopianism in song
Authors: Kintner Amy 
Published: November 2015

AbstractJoni Mitchell's ‘Woodstock’ is one of the most recognisable songs about the 1969 festival, yet Mitchell did not attend Woodstock and instead wrote her song in a New York City hotel room. The song ‘Woodstock’, then, represents the event not as it literally happened, but as it could have been, as an idealised depiction of nostalgia for the festival and the era's utopian potential. I analyse Mitchell's song as a utopian text and investigate the political efficacy of ‘Woodstock's musical and lyrical content for Mitchell, for other artists who cover the song, and for audiences who may recognise it as the festival's ‘theme’. As her career continues, Mitchell abandons the folk-based style of her early albums, but keeps ‘Woodstock’ an active part of her performance repertoire. I trace three later versions to show that the utopianism of the original disappears as Mitchell re-imagines the song, the event and its ideological legacy.
Baudrillard's Blues
Authors: Mueller Charles 
Published: November 2015

AbstractIn his book, America, Jean Baudrillard characterised the United States as a nation created for the sole purpose of escaping history, a place that has purged itself of all negativity, and whose citizens live life in a perpetual present. Baudrillard's study of America provides an ideal framework with which to examine the ways that blues is both congenial and antithetical to postmodern America, and how the significations and meanings of blues have changed as the music has passed from modernity to postmodernity. Of particular interest is the question of whether African-American interpretations of blues can remain privileged. Examining blues music in the context of America provides clear cultural examples that support many of Baudrillard's often obscure metaphysical observations.
Chinstrap and macaroni penguin diet and demography at Nyrøysa, Bouvetøya
Authors: Niemandt Corne , Kovacs Kit M. , Lydersen Christian , Dyer Bruce M. , Isaksen Kjell , Hofmeyr G.J. Greg , Mehlum Fridtjof , de Bruyn P.J. Nico 
Published: November 2015

AbstractKnowledge regarding interactions between predators and their prey is fundamental for understanding underlying links between climate change and ecosystem responses, including predator demographics, in the Southern Ocean. This study reports data on reproductive performance, total population size and diet composition for macaroni and chinstrap penguins breeding at Nyrøysa on Bouvetøya during the summers of 1996–97, 1998–99, 2000–01 and 2007–08. The breeding populations of these two species at Nyrøysa decreased significantly over the study period, with an 80% decline for chinstraps and a 50% decline for macaroni penguins, despite relatively high levels of chick production. During this period macaroni penguins at this site ate a diverse diet, dominated by myctophid fish and two krill species, whereas chinstrap penguins were Antarctic krill specialists. The population changes are probably primarily due to the expanding Antarctic fur seal population, and also to landslides that are the result of increased melting on the island which have destroyed penguin breeding sites. Additional impacts from global warming of the ocean might also be playing a role and could exacerbate the decline in these penguin populations if krill and other prey are negatively impacted in the future in this region. The local chinstrap penguin population would probably be most heavily affected given its narrow feeding niche and small current population size.
Factor VII promotes hepatocellular carcinoma progression through ERK-TSC signaling
Authors: Tsai M-C , Chen K-D , Wang C-C , Huang K-T , Wu C-H , Kuo I-Y , Chen L-Y , Hu T-H , Goto S , Nakano T , Dorling A , McVey J H , Chen C-L , Lin C-C 
Published: November 2015

AbstractWe previously demonstrated PAR2 starts upstreamed with tissue factor (TF) and factor VII (FVII), inhibited autophagy via mTOR signaling in HCC. However, the mechanism underlying for merging functions of PAR2 with the coagulation system in HCC progression remained unclear. The present study aimed to investigate the role of TF, FVII and PAR2 in tumor progression of HCC. The expressions of TF, FVII and PAR2 from HCC specimens were evaluated by immunohistochemical stains and western blotting. We found that the expression of FVII, but not TF and PAR2, directly related to the vascular invasion and the clinical staging. Importantly, a lower level of FVII expression was significantly associated with the longer disease-free survival. The addition of FVII but not TF induced the expression of PAR2 and phosphorylation of ERK1/2, whereas knockdown of FVII decreased PAR2 expression and ERK1/2 phosphorylation in HCC cell lines. Furthermore, levels of phosphor-TSC2 (Ser664) were increased after treatment with FVII and PAR2 agonist whereas these were significantly abolished in the presence of a potent and specific MEK/ERK inhibitor U0126. Moreover, mTOR knockdown highly reduced Hep3B migration, which could be reverted by FVII but not TF and PAR2. These results indicated that FVII/PAR2 signaling through MEK/ERK and TSC2 axis for mTOR activation has potent effects on the migration of HCC cells. In addition, FVII/PAR2 signaling elicits an mTOR-independent signaling, which promotes hepatoma cell migration in consistent with the clinical observations. Our study indicates that levels of FVII, but not TF, are associated with tumor migration and invasiveness in HCC, and provides clues that evaluation of FVII expression in HCC may be useful as a prognostic indicator in patients with HCC and may form an alternative target for further therapy.
An endoscope with integrated transparent bioelectronics and theranostic nanoparticles for colon cancer treatment
Authors: Lee Hyunjae , Lee Youngsik , Song Changyeong , Cho Hye Rim , Ghaffari Roozbeh , Choi Tae Kyu , Kim Kyung Hoon , Lee Young Bum , Ling Daishun , Lee Hyuk , Yu Su Jong , Choi Seung Hong , Hyeon Taeghwan , Kim Dae-Hyeong 
Published: November 2015

AbstractThe gastrointestinal tract is a challenging anatomical target for diagnostic and therapeutic procedures for bleeding, polyps and cancerous growths. Advanced endoscopes that combine imaging and therapies within the gastrointestinal tract provide an advantage over stand-alone diagnostic or therapeutic devices. However, current multimodal endoscopes lack the spatial resolution necessary to detect and treat small cancers and other abnormalities. Here we present a multifunctional endoscope-based interventional system that integrates transparent bioelectronics with theranostic nanoparticles, which are photoactivated within highly localized space near tumours or benign growths. These advanced electronics and nanoparticles collectively enable optical fluorescence-based mapping, electrical impedance and pH sensing, contact/temperature monitoring, radio frequency ablation and localized photo/chemotherapy, as the basis of a closed-loop solution for colon cancer treatment. In vitro, ex vivo and in vivo experiments highlight the utility of this technology for accurate detection, delineation and rapid targeted therapy of colon cancer or precancerous lesions.
A tunable artificial circadian clock in clock-defective mice
Authors: D’Alessandro Matthew , Beesley Stephen , Kim Jae Kyoung , Chen Rongmin , Abich Estela , Cheng Wayne , Yi Paul , Takahashi Joseph S. , Lee Choogon 
Published: November 2015

AbstractSelf-sustaining oscillations are essential for diverse physiological functions such as the cell cycle, insulin secretion and circadian rhythms. Synthetic oscillators using biochemical feedback circuits have been generated in cell culture. These synthetic systems provide important insight into design principles for biological oscillators, but have limited similarity to physiological pathways. Here we report the generation of an artificial, mammalian circadian clock in vivo, capable of generating robust, tunable circadian rhythms. In mice deficient in Per1 and Per2 genes (thus lacking circadian rhythms), we artificially generate PER2 rhythms and restore circadian sleep/wake cycles with an inducible Per2 transgene. Our artificial clock is tunable as the period and phase of the rhythms can be modulated predictably. This feature, and other design principles of our work, might enhance the study and treatment of circadian dysfunction and broader aspects of physiology involving biological oscillators.
Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis
Authors: Bunda Severa , Burrell Kelly , Heir Pardeep , Zeng Lifan , Alamsahebpour Amir , Kano Yoshihito , Raught Brian , Zhang Zhong-Yin , Zadeh Gelareh , Ohh Michael 
Published: November 2015

AbstractRas is phosphorylated on a conserved tyrosine at position 32 within the switch I region via Src kinase. This phosphorylation inhibits the binding of effector Raf while promoting the engagement of GTPase-activating protein (GAP) and GTP hydrolysis. Here we identify SHP2 as the ubiquitously expressed tyrosine phosphatase that preferentially binds to and dephosphorylates Ras to increase its association with Raf and activate downstream proliferative Ras/ERK/MAPK signalling. In comparison to normal astrocytes, SHP2 activity is elevated in astrocytes isolated from glioblastoma multiforme (GBM)-prone H-Ras(12V) knock-in mice as well as in glioma cell lines and patient-derived GBM specimens exhibiting hyperactive Ras. Pharmacologic inhibition of SHP2 activity attenuates cell proliferation, soft-agar colony formation and orthotopic GBM growth in NOD/SCID mice and decelerates the progression of low-grade astrocytoma to GBM in a spontaneous transgenic glioma mouse model. These results identify SHP2 as a direct activator of Ras and a potential therapeutic target for cancers driven by a previously ‘undruggable’ oncogenic or hyperactive Ras.
The application of omics technologies in the functional evaluation of inulin and inulin-containing prebiotics dietary supplementation
Authors: Tsurumaki M , Kotake M , Iwasaki M , Saito M , Tanaka K , Aw W , Fukuda S , Tomita M 
Published: November 2015

AbstractInulin, a natural renewable polysaccharide resource produced by various plants in nature, has been reported to possess a significant number of diverse pharmaceutical and food applications. Recently, there has been rapid progress in high-throughput technologies and platforms to assay global mRNA, proteins, metabolites and gut microbiota. In this review, we will describe the current status of utilizing omics technologies of elucidating the impact of inulin and inulin-containing prebiotics at the transcriptome, proteome, metabolome and gut microbiome levels. Although many studies in this review have addressed the impact of inulin comprehensively, these omics technologies only enable us to understand physiological information at each different stage of mRNA, protein, metabolite and gut microbe. We believe that a synergistic approach is vital in order to fully illustrate the intricate beauty behind the relatively modest influence of food factors like inulin on host health.
Prognostic significance of Versican expression in gastric adenocarcinoma
Authors: Shen X-H , Lin W-R , Xu M-D , Qi P , Dong L , Zhang Q-Y , Ni S-J , Weng W-W , Tan C , Huang D , Ma Y-Q , Zhang W , Sheng W-Q , Wang Y-Q , Du X 
Published: November 2015

AbstractGastric cancer (GC) is the leading malignancy in the digestive system. Versican is a ubiquitous component of the extracellular matrix and has a role in tumor progression. We aim to examine the expression of Versican in GC and the relationship between Versican levels and patient survival. We detected the mRNA expression of Versican in tumorous pairs and adjacent normal tissues (ANTs) of 78 GC patients by quantitative real-time polymerase chain reaction. The protein expression of Versican in 101 cases of matched GC and ANT, as well as in 27 intraepithelial neoplastic (IN) samples, was evaluated by immunohistochemistry. We analyzed the correlation between Versican levels and clinical outcomes. Finally, we performed CCK-8 cell counting assay and transwell assay in GC cell lines. Versican mRNA expression was significantly greater in tumor tissues (P<0.001) than in ANT. Versican was majorly expressed in the stroma surrounding tumor epithelium and minorly some areas of tumor epithelium. The Versican expression level was higher in GC than in ANT (P=0.004), but no significant difference was observed between ANT and IN (P=0.517). The Versican mRNA and protein levels were consistent in GC. High Versican mRNA and protein expression correlated with greater tumor invasion depth (P=0.030, P=0.027). Univariate and multivariate analysis revealed that patients with high Versican mRNA expression exhibited poor disease-specific survival (P<0.001). In vitro experiments showed that Versican overexpression promoted cell proliferation and invasion. Our data indicate that Versican may be a novel prognostic indicator in GC and may be a potential target for clinical diagnosis.
The power of single molecule real-time sequencing technology in the de novo assembly of a eukaryotic genome
Authors: Sakai Hiroaki , Naito Ken , Ogiso-Tanaka Eri , Takahashi Yu , Iseki Kohtaro , Muto Chiaki , Satou Kazuhito , Teruya Kuniko , Shiroma Akino , Shimoji Makiko , Hirano Takashi , Itoh Takeshi , Kaga Akito , Tomooka Norihiko 
Published: November 2015

AbstractSecond-generation sequencers (SGS) have been game-changing, achieving cost-effective whole genome sequencing in many non-model organisms. However, a large portion of the genomes still remains unassembled. We reconstructed azuki bean (Vigna angularis) genome using single molecule real-time (SMRT) sequencing technology and achieved the best contiguity and coverage among currently assembled legume crops. The SMRT-based assembly produced 100 times longer contigs with 100 times smaller amount of gaps compared to the SGS-based assemblies. A detailed comparison between the assemblies revealed that the SMRT-based assembly enabled a more comprehensive gene annotation than the SGS-based assemblies where thousands of genes were missing or fragmented. A chromosome-scale assembly was generated based on the high-density genetic map, covering 86% of the azuki bean genome. We demonstrated that SMRT technology, though still needed support of SGS data, achieved a near-complete assembly of a eukaryotic genome.
A cost-effective system for differentiation of intestinal epithelium from human induced pluripotent stem cells
Authors: Ogaki Soichiro , Morooka Mayu , Otera Kaito , Kume Shoen 
Published: November 2015

AbstractThe human intestinal epithelium is a useful model for pharmacological studies of absorption, metabolism, drug interactions and toxicology, as well as for studies of developmental biology. We established a rapid and cost effective system for differentiation of human induced pluripotent stem (iPS) cells into definitive endoderm (DE) cells. In the presence of dimethyl sulfoxide (DMSO), a low concentration of Activin at 6.25 ng/ml is sufficient to give a similar differentiation efficiency with that using Activin at 100 ng/ml at the presence of Wnt activator. In the presence of DMSO, Activin at low concentration triggered hiPS cells to undergo differentiation through G1 arrest, reduce apoptosis and potentiate activation of downstream targets, such as SMAD2 phosphorylation and SOX17 expression. This increased differentiation into CDX2 + SOX17 + DE cells. The present differentiation procedure therefore permits rapid and efficient derivation of DE cells, capable of differentiating into intestinal epithelium upon BIO and DAPT treatment and of giving rise to functional cells, such as enterocytes.
Mulberry fruit prevents LPS-induced NF-κB/pERK/MAPK signals in macrophages and suppresses acute colitis and colorectal tumorigenesis in mice
Authors: Qian Zhengjiang , Wu Zhiqin , Huang Lian , Qiu Huiling , Wang Liyan , Li Li , Yao Lijun , Kang Kang , Qu Junle , Wu Yonghou , Luo Jun , Liu Johnson J. , Yang Yi , Yang Wancai , Gou Deming 
Published: November 2015

AbstractHere, we investigated the impact of mulberry fruit (MBF) extracts on lipopolysaccharide (LPS)-induced inflammatory responses in RAW 264.7 macrophages and the therapeutic efficacy of MBF diet in mice with dextran sulfate sodium (DSS)-induced acute colitis and MUC2−/− mice with colorectal cancer. In vitro, LPS-induced nitric oxide (NO) production was significantly inhibited by MBF extracts via suppressing the expression of proinflammatory molecules, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin-1 beta (IL-β) and IL-6. Particularly, a dose-dependent inhibition on LPS-induced inflammatory responses was observed following treatment with MBF dichloromethane extract (MBF-DE), in which linoleic acid and ethyl linolenate were identified as two active compounds. Moreover, we elucidated that MBF-DE attenuated LPS-induced inflammatory responses by blocking activation of both NF-κB/p65 and pERK/MAPK pathways. In vivo, DSS-induced acute colitis was significantly ameliorated in MBF-fed mice as gauged by weight loss, colon morphology and histological damage. In addition, MBF-fed MUC2−/− mice displayed significant decrease in intestinal tumor and inflammation incidence compared to control diet-fed group. Overall, our results demonstrated that MBF suppressed the development of intestinal inflammation and tumorgenesis both in vitro and in vivo and supports the potential of MBF as a therapeutic functional food for testing in human clinical trials.
CMOS integration of inkjet-printed graphene for humidity sensing
Authors: Santra S. , Hu G. , Howe R. C. T. , De Luca A. , Ali S. Z. , Udrea F. , Gardner J. W. , Ray S. K. , Guha P. K. , Hasan T. 
Published: November 2015

AbstractWe report on the integration of inkjet-printed graphene with a CMOS micro-electro-mechanical-system (MEMS) microhotplate for humidity sensing. The graphene ink is produced via ultrasonic assisted liquid phase exfoliation in isopropyl alcohol (IPA) using polyvinyl pyrrolidone (PVP) polymer as the stabilizer. We formulate inks with different graphene concentrations, which are then deposited through inkjet printing over predefined interdigitated gold electrodes on a CMOS microhotplate. The graphene flakes form a percolating network to render the resultant graphene-PVP thin film conductive, which varies in presence of humidity due to swelling of the hygroscopic PVP host. When the sensors are exposed to relative humidity ranging from 10–80%, we observe significant changes in resistance with increasing sensitivity from the amount of graphene in the inks. Our sensors show excellent repeatability and stability, over a period of several weeks. The location specific deposition of functional graphene ink onto a low cost CMOS platform has the potential for high volume, economic manufacturing and application as a new generation of miniature, low power humidity sensors for the internet of things.