bluuebunny/crossref_metadata_2025_split huggingface dataset:
The application of lung immune prognostic index in predicting the prognosis of 302 STS patients
Authors: Jiang Yong , Zou Chang , He Xuanhong , Li Longqing , Luo Yi , Lu Minxun , Li Zhuangzhuang , Gong Taojun , Wang Yitian , Min Li , Zhou Yong , Tu Chongqi 
Published: September 2024

BackgroundSoft tissue sarcoma (STS) are heterogeneous and rare tumors, and few studies have explored predicting the prognosis of patients with STS. The Lung Immune Prognostic Index (LIPI), calculated based on baseline serum lactate dehydrogenase (LDH) and the derived neutrophils/(leukocytes minus neutrophils) ratio (dNLR), was considered effective in predicting the prognosis of patients with pulmonary cancer and other malignancies. However, the efficacy of the LIPI in predicting the prognosis of patients with STS remains unclear.MethodsThis study retrospectively reviewed patients with STS admitted to our center from January 2016 to January 2021. Their hematological and clinical characteristics were collected and analyzed to construct the LIPI specific to STS. The correlations between various predictive factors and overall survival (OS) were examined using Kaplan–Meier and Cox regression analyses. Independent risk factors for OS were identified using univariate and multivariate analyses. Finally, a LIPI nomogram model for STS was established.ResultsThis study enrolled 302 patients with STS, of which 87 (28.9%), 162 (53.6%), and 53 (17.5%) were classified into three LIPI-based categories: good, moderate, and poor, respectively (P &lt; 0.0001). The time-dependent operator curve showed that the LIPI had better prognostic predictive ability than other hematological and clinical characteristics. Univariate and multivariate analyses identified the Fédération Nationale des Centres de Lutte Contre le Cancer grade (FNCLCC/G), tumor size, and LIPI as independent risk factors. Finally, a nomogram was constructed by integrating the significant prognostic factors. Its C-index was 0.72, and the calibration curve indicated that it could accurately predict the three- and five-year OS of patients with STS. The decision and clinical impact curves also indicated that implementing this LIPI-nomogram could significantly benefit patients with STS.ConclusionThis study explored the efficacy of the LIPI in predicting the prognosis of 302 patients with STS, classifying them into three categories to evaluate the prognosis. It also reconstructed a LIPI-based nomogram to assist clinicians in predicting the three- and five-year OS of patients with STS, potentially enabling timely intervention and customized management.
Characterization of mesothelin gene expression in dogs and overexpression in canine mesotheliomas
Authors: Nabeta Rina , Kanaya Ami , Shimada Kazumi , Matsuura Katsuhiro , Yoshimura Aritada , Oyamada Tomohiro , Azakami Daigo , Furuya Tetsuya , Uchide Tsuyoshi 
Published: September 2024

IntroductionCanine mesotheliomas are uncommon malignant tumors typically detected late. Minimally invasive diagnostic biomarkers would facilitate diagnosis at earlier stages, thereby improving clinical outcomes. We hypothesized that mesothelin could be used as a reliable diagnostic biomarker for canine mesotheliomas since it has been used as a cancer biomarker for human mesothelioma. We aimed to explore and characterize mesothelin gene expression in dogs and assess its use as a diagnostic biomarker for canine mesotheliomas.Materials and methodsWe quantified expressed canine mesothelin transcripts via reverse transcription polymerase chain reaction (RT-PCR) and sequenced them using ribonucleic acid (RNA) extracted from a canine mesothelioma cell line. After confirming mesothelin expression, we assessed its levels in major organ tissues and compared them with those in the mesothelioma tissues using quantitative PCR (qPCR). Mesothelin overexpression in mesotheliomas was detected, and we further compared its levels using qPCR between mesotheliomas and non-mesotheliomas using tumor tissues and clinical sample effusions, confirming its significance as a diagnostic biomarker for canine mesothelioma.ResultsMesothelin complementary deoxyribonucleic acid (cDNA) was amplified via RT-PCR, yielding a single band of expected upon DNA electrophoresis. Sequence analyses confirmed it as a predicted canine mesothelin transcript from the genome sequence database. Comparative sequence analysis of the deduced amino acid sequence of the expressed canine mesothelin demonstrated molecular signature similarities with the human mesothelin. However, the pre-sequence of canine mesothelin lacks the mature megakaryocyte potentiating factor (MPF) portion, which is typically cleaved post-translationally with furin. Mesothelin expression was quantified via qPCR revealing low levels in the mesothelial and lung tissues, with negligible expression in the other major organs. Canine mesothelin exhibited significantly higher expression in the canine mesotheliomas than in the noncancerous tissues. Moreover, analysis of clinical samples using qPCR demonstrated markedly elevated mesothelin expression in canine mesotheliomas compared to non-mesothelioma cases.Discussion and conclusionCanine mesothelin exhibits molecular and biological characteristics akin to human mesothelin. It could serve as a vital biomarker for diagnosing canine mesotheliomas, applicable to both tissue- and effusion-based samples.
Formation of pseudo-morphic domain in Cr2O3(0001) epitaxial film grown on α-Al2O3(0001) and its effect on Néel temperature
Authors: Ekawa Hirofumi , Sameshima Hiroki , Toyoki Kentaro , Nakatani Ryoichi , Shiratsuchi Yu 
Published: September 2024

Abstract
To address the issue of the impact of the epitaxial strain on the Néel temperature T
N, we investigated the formation of the epitaxial domain in the Cr2O3 layer grown on the α-Al2O3(0001) substrate isostructural to Cr2O3 and determined T
N of the fabricated films. We varied the sputtering power for the Cr2O3 growth from 10 W to 40 W to alter the strain condition of the epitaxial film. When the sputtering power is 10 W, the single epitaxial domain is formed, whereas the pseudo-morphic and relaxed domains coexist for the sputtering power above 20 W. T
N decreased from about 271 K to below 252 K accompanied by the formation of the two types of epitaxial domains. The lattice parameters of the pseudo-morphic domain are beyond the elastic deformation approximation adopted in the theoretical approaches, suggesting that the correlation between the T
N value and the microstructure also goes beyond the existing theoretical framework.
ANÁLISE DA SAÚDE MENTAL DE GESTANTES DIANTE DOS CUIDADOS OBSTÉTRICOS
Authors: Lima Pena Maria Luisa , Suhett Caiado Yaritza , Alves Gratival Francine , Santos Raymundo Norma Lucia , Afonso Dinis de Mesquita Francisco , Montini Ramos Azenha Kizzy , Aldenora dos Santos Jaçamar 
Published: September 2024

Introdução: As alterações fisiológicas do corpo gravídico apresentam oscilações hormonais que modificam os eixos hormonais associados aos transtornos de humor durante e após a gestação. As intervenções desnecessárias e potencialmente iatrogênicas, que agravam as alterações na saúde mental e física materno-infantil , podem impactar no sentimento de confiança e competência no processo da maternidade, resultando no desenvolvimento de transtornos psiquiátricos. Objetivo: Analisar como os cuidados obstétricos no pré-parto e parto influenciam na saúde mental da parturiente na saúde pública. Método: Estudo do tipo descritivo, quali-quantitativo, baseado em dados coletados a partir de entrevistas gravadas no pré-natal e puerpério e análise de prontuários eletrônicos do hospital-maternidade pró-matre no período de janeiro até agosto de 2023. Resultados: Foi observado que 87% das gestantes não planejaram a gravidez, isso refletiu em boa parte delas não estarem desejosas no início da gestação. Em razão disso, foram repetidos os dizeres “ansiosa” e “medo” quando perguntado acerca da expectativa do parto. A variabilidade dos hormônios reprodutivos pode contribuir com o processamento cognitivo das emoções, podendo predispor ou agravar condições psiquiátricas, como a depressão pós-parto. Desta forma, evidencia-se a importância da triagem para depressão durante a gestação e após o parto. Discussão: O medo e a ansiedade que envolvem o parto normal, associados com a falta de informação acerca de como é o trabalho de parto, os processos de indução e os riscos da cesariana fazem crescer a falsa ideia de que se submeter a uma cirurgia é o melhor caminho por ser “mais fácil” e “menos doloroso”. Conclusão: más experiências vivenciadas por gestantes durante o trabalho de parto influenciam na falta de confiança e autonomia da mulher em uma próxima gestação, além de aumentar o risco de precipitar ou agravar problemas psiquiátricos. Dessa forma, é necessária a garantia da autonomia e dignidade da mulher durante o trabalho de parto, bem como assegurar a saúde mental de puérperas, para enfim proporcionar uma boa experiência com o parto.

Palavras-chave: Gravidez. Cuidados. Saúde Mental. Período Pós-Parto. Parto Humanizado.
Penyuluhan Tentang Manfaat Mengkonsumsi Yoghurt Dan Cara Pembuatannya Guna Mendorong Ekonomi Serta Kesehatan Masyarakat Di Kelurahan Sukamakmur Pemataangsiantar
Authors: Sinaga Dian Perayanti , Damanik Risjunardi , Siboro Thiur Dianti , Purba Sumarny Tridelpina , Saragih Marlindoaman 
Published: September 2024

Kegiatan pengabdian kepada Masyarakat (PKM) di kelurahan Sukamakmur Kecamatan Siantar Marihat Kota Pematang Siantar ini berupa penyuluhan tentang pentingnya mengkonsumsi yoghurt, kandungan dan metode Pembuatan yoghurt dengan menggunakan metode sederhana dan biaya yang relatif terjangkau. Kegiatan penyuluhan pembuatan yoghurt ini dilakukan untuk meningkatkan konsumsi makanan bergiji bagi masyarakat, khusunya berbahan susu. Tujuan kegiatan ini adalah untuk meningkatkan pengetahuan masyarakat tentang manfaat mengkonsumsi yoghurt dan memberikan keterampilan baru untuk membuat yoghurt sendiri yang lebih terjangkau dan disukai. Respon Masyarakat Kelurahan Sukamakmur khususnya para ibu PKK terhadap penyuluhan ini cukup tinggi, ditunjukkan dengan angka kehadiran 80 % dari jumlah undangan. Pemahaman masyarakat terhadap pentingnya dan kandungan yoghurt serta cara pembuatan yoghurt yang benar menggunakan metode sederhana dan murah ini ditanggapi dengan sangat antusias oleh para ibu PKK. Hal ini ditunjukkan dengan dijadikannya pelatihan pembuatan yoghurt sebagai salah satu agenda kegiatan PKK di lingkungan kelurahan Sukamakmur
Sosialisasi Bahaya Penyalahgunaan Narkoba Bagi Peserta Didik SMIP Yayasan Universitas Simalungun Pematangsiantar
Authors: Napitu Ulung , Corry  , Sihaloho Bongguk , Harianja Tuangkus , Ease Aren  , Nasution Tuty Ariani , Saragih Rosmery , Napitu Hasian , Sinaga Rosdiana 
Published: September 2024

Kegiatan sosialisasi bahaya penyalahgunaan narkoba pada SMIP Yayasan USI Pematang siantar bertujuan agar peserta didik dapat memahami dampak yang timbul dari penggunaan narkoba ( fisik, psikis maupun sosial ekonomi). Sosialisasi ini menggunakan metode partisipatif, ceramah dan diskusi. kegiatan sosialisasi ini dilaksanakan pada tanggal 14 april 2023 dengan jumlah peserta sosialisasi terdiri dari 25 orang peserta didik dan 10 orang guru yang berlokasi di aula SMIP Yayasan. Melalui kegiatan sosialisasi bahaya penyalahgunaan narkoba ini diharapkan mampu meningkatkan pemahaman peserta didik tentang jenis - jenis narkotika, dampak penyalahgunaan narkoba dari aspek fisik, psikis, pendidikan, sosial dan ekonomi serta cara pencegahan dan penanggulangannya. Kegiatan sosialisasi ini bermanfaat membentengi generasi muda sebagai generasi penerus bangsa khususnya peserta didik SMIP Yayasan USI dari bahaya penyalahgunaan narkoba
Green Synthesis of Silver Nanoparticles from Rotheca serrata (L.) Steane & Mabb., its Physicochemical Characterization and Evaluation of its Biological Activities
Authors: S Gejalakshmi , N Harikrishnan , G Kiranmay 
Published: September 2024

Dear Editor,
I was reading the article which was cited above titled ‘Green synthesis of silver nanoparticles from Rotheca serrata (L.) Steane & Mabb., its physicochemical Characterization and Evaluation of its Biological Activities which was ideal and novel attracted the importance of nanoscience and its utility in the field of medicine1-2.
The novel synthesis of nano-based particles has played a pivotal role in the scientific field with green synthesis as a pollution-emerging synthesis which emphasises a cost-effective alternative medicine3
The main purpose of the study focused on green synthesis utilizing silver nanoparticles (Ag NPs) using specific leaf extract of Rotheca serrata (L.) Steane and Mabb belong to the family Verbenacea. The author aimed to characterize these nanoparticles and performed the evaluation study for antibacterial, antioxidant and anti-inflammatory activity and their effects on the seed germination process.
MALIGNANT STRUMA OVARII (KASUS LANGKA)
Authors: Adi Arianto  , Udadi Sadhana  
Published: September 2024

Struma ovarii (SO) are rare and accur in 2-3% of mature ovarian teratomas, most SO cases are benign. Malignant struma ovarii (MSO) is even more rare and occurs in 0,5- 5% of all cases, with the most common histologies identified are papillary and follicular carcinoma, most commonly affect patients in their 4th to 6th decade of life. Due to the rarity of malignant transformation, data about its management are lacking. A 49-years-old woman P2A0 with abdominal pain and pelvic mass, admitted for a hysterectomy and bilateral salpingo-oophorectomy. The left ovary was measured 13x11x5 cm, cystic and partly solid, filled with gelatinous fluid, composed of thyroid follicles with the appearance of "ground glass", "nuclear inclusion" and "nuclear groove", forming a papillifer structure. The diagnostic of MSO is based on histological features include cellular atypia, increased hyperplasia, nuclear pleomorphism, mitotic activity, vascular and/or capsular invasion. To be classified as a MSO, teratoma containing 50% or more thyroid tissue. MSO necessitates surgical staging for ovarian cancer with pelvic washings, total abdominal hysterectomy, bilateral salpingo- oophorectomy, lymph node sampling, total thyroidectomy, and radioactive I-131 ablation. Based on the clinical examination and histopatological examination the patient was diagnosed with MSO (ICD O: 9090/3).
An Efficient Observational Strategy for the Detection of the Oort Cloud
Authors: Ofek Eran O. , Spitzer Sarah A. , Nir Guy 
Published: September 2024

Abstract
The Oort cloud is presumably a pristine relic of the solar system formation. Detection of the Oort cloud may provide information regarding the stellar environment in which the Sun was born and on the planetesimal population during the outer planets’ formation phase. The best suggested approach for detecting Oort cloud objects in situ, is by searching for subsecond occultations of distant stars by these objects. Following Brown & Webster, we discuss the possibility of detecting Oort cloud objects by observing near the quadrature direction. Due to the Earth’s projected velocity, the occultations are longer near the quadrature direction and are therefore easier to detect, but have lower rate. We show that, for ≲1 m size telescopes, the increased exposure time will result in about one to 3 orders of magnitude increase in the number of detectable stars that have an angular size smaller than the Fresnel scale and are therefore suitable for an occultation search. We discuss the ability of this method to detect Oort cloud objects using existing survey telescopes, and we estimate the detection rate as a function of the power-law index of the size distribution of the Oort cloud objects and their distance from the Sun. We show that occultations detected using ≈1 s integration by ≲1 m telescopes at the optimal region near the quadrature points will be marginally dominated by Oort cloud objects rather than Kuiper belt objects.
SN 2022oqm: A Bright and Multipeaked Calcium-rich Transient
Authors: Yadavalli S. Karthik , Villar V. Ashley , Izzo Luca , Zenati Yossef , Foley Ryan J. , Wheeler J. Craig , Angus Charlotte R. , Bánhidi Dominik , Auchettl Katie , Bíró Barna Imre , Bódi Attila , Bodola Zsófia , de Boer Thomas , Chambers Kenneth C. , Chornock Ryan , Coulter David A. , Csányi István , Cseh Borbála , Dandu Srujan , Davis Kyle W. , Dickinson Connor Braden , Farias Diego , Farah Joseph , Gall Christa , Gao Hua , Howell D. Andrew , Jacobson-Galan Wynn V. , Khetan Nandita , Kilpatrick Charles D. , Könyves-Tóth Réka , Kriskovics Levente , LeBaron Natalie , Loertscher Kayla , Le Saux X. K. , Margutti Raffaella , Magnier Eugene A. , McCully Curtis , McGill Peter , Miao Hao-Yu , Newsome Megan , Padilla Gonzalez Estefania , Pál András , Pál Boróka H. , Pan Yen-Chen , Politsch Collin A. , Ransome Conor L. , Ramirez-Ruiz Enrico , Rest Armin , Rest Sofia , Robinson Olivia , Sears Huei , Scheer Jackson , Sódor Ádám , Swift Jonathan , Székely Péter , Szakáts Róbert , Szalai Tamás , Taggart Kirsty , Terreran Giacomo , Venkatraman Padma , Vinkó József , Yang Grace , Zhou Henry 
Published: September 2024

Abstract
We present the photometric and spectroscopic evolution of SN 2022oqm, a nearby multipeaked hydrogen- and helium-weak calcium-rich transient (CaRT). SN 2022oqm was detected 13.1 kpc from its host galaxy, the face-on spiral galaxy NGC 5875. Extensive spectroscopic coverage reveals an early hot (T ≥ 40,000 K) continuum and carbon features observed ∼1 day after discovery, SN Ic-like photospheric-phase spectra, and strong forbidden calcium emission starting 38 days after discovery. SN 2022oqm has a relatively high peak luminosity (M

B
= −17 mag) for CaRTs, making it an outlier in the population. We determine that three power sources are necessary to explain the light curve (LC), with each corresponding to a distinct peak. The first peak is powered by an expanding blackbody with a power-law luminosity, suggesting shock cooling by circumstellar material (CSM). Subsequent LC evolution is powered by a double radioactive decay model, consistent with two sources of photons diffusing through optically thick ejecta. From the LC, we derive an ejecta mass and 56Ni mass of ∼0.6 M
⊙ and ∼0.09 M
⊙. Spectroscopic modeling ∼0.6 M
⊙ of ejecta, and with well-mixed Fe-peak elements throughout. We discuss several physical origins for SN 2022oqm and find either a surprisingly massive white dwarf progenitor or a peculiar stripped envelope model could explain SN 2022oqm. A stripped envelope explosion inside a dense, hydrogen- and helium-poor CSM, akin to SNe Icn, but with a large 56Ni mass and small CSM mass could explain SN 2022oqm. Alternatively, helium detonation on an unexpectedly massive white dwarf could also explain SN 2022oqm.
Rest-frame Optical Spectroscopy of Ten z ∼ 2 Weak Emission-line Quasars
Authors: Chen Y. , Luo B. , Brandt W. N. , Zuo Wenwen , Dix Cooper , Ha Trung , Matthews Brandon , Paul Jeremiah D. , Plotkin Richard M. , Shemmer Ohad 
Published: September 2024

Abstract
We present near-infrared spectroscopy of 10 weak emission-line quasars (WLQs) at redshifts of z ∼ 2, obtained with the Palomar 200 inch Hale Telescope. WLQs are an exceptional population of type 1 quasars that exhibit weak or no broad emission lines in the ultraviolet (e.g., the C iv
λ1549 line), and they display remarkable X-ray properties. We derive Hβ-based single-epoch virial black hole masses (median value 1.7 × 109
M
⊙) and Eddington ratios (median value 0.5) for our sources. We confirm the previous finding that WLQ Hβ lines, as a major low-ionization line, are not significantly weak compared to typical quasars. The most prominent feature of the WLQ optical spectra is the universally weak/absent [O iii] λ5007 emission. They also display stronger optical Fe ii emission than typical quasars. Our results favor the super-Eddington accretion scenario for WLQs, where the weak lines are a result of a soft ionizing continuum; the geometrically thick inner accretion disk and/or its associated outflow is responsible for obscuring the nuclear high-energy radiation and producing the soft ionizing continuum. We also report candidate extreme [O iii] outflows (blueshifts of ≈500 and 4900 km s−1) in one object.
Measurements of the Low-acceleration Gravitational Anomaly from the Normalized Velocity Profile of Gaia Wide Binary Stars and Statistical Testing of Newtonian and Milgromian Theories
Authors: Chae Kyu-Hyun 
Published: September 2024

Abstract
Low-acceleration gravitational anomaly is investigated with a new method of exploiting the normalized velocity profile

v

˜

≡

v

p

/

v

c

of wide binary stars as a function of the normalized sky-projected radius s/r
M, where v

p
is the sky-projected relative velocity between the pair, v

c
is the Newtonian circular velocity at the sky-projected separation s, and r
M is the MOND radius. With a Monte Carlo method, Gaia observed binaries and their virtual Newtonian counterparts are probabilistically distributed on the s/r
M versus

v

˜

plane, and a logarithmic velocity ratio parameter Γ is measured in the bins of s/r
M. With three samples of binaries covering a broad range in size, data quality, and implied fraction of hierarchical systems including a new sample of 6389 binaries selected with accurate distances and radial velocities, I find a unanimous systematic variation from the Newtonian flat line. With Γ = 0 at s/r
M ≲ 0.15 or s ≲ 1 kau, I get Γ = 0.068 ± 0.015 (stat)

−
0.015

+
0.024

(syst) for s/r
M ≳ 0.7 or s ≳ 5 kau. The gravitational anomaly (i.e., acceleration boost) factor given by γ

g
= 102Γ is measured to be

γ

g

=

1.37

−
0.09

+
0.10

(stat)

−
0.09

+
0.16

(syst). With a reduced χ
2 test of Newtonian and Milgromian nonrelativistic theories, I find that Newtonian gravity is ruled out at 5.8σ (

χ

ν

2

=
9.4

) by the new sample (and 9.2σ by the largest sample used). The Milgromian AQUAL theory is acceptable with

0.7
≲

χ

ν

2

≲
3.1

. These results agree well with earlier results with the “acceleration-plane analysis” for a variety of samples and the “stacked velocity profile analysis” for a pure binary sample.
New Strong Gravitational Lenses from the DESI Legacy Imaging Surveys Data Release 9
Authors: Storfer C. , Huang X. , Gu A. , Sheu W. , Banka S. , Dey A. , Inchausti Reyes J. , Jain A. , Kwon K. J. , Lang D. , Lee V. , Meisner A. , Moustakas J. , Myers A. D. , Tabares-Tarquinio S. , Schlafly E. F. , Schlegel D. J. 
Published: September 2024

Abstract
We have conducted a search for strong gravitational lensing systems in the Dark Energy Spectroscopic Instrument (DESI) Legacy Imaging Surveys Data Release 9. This is the third paper in a series. These surveys together cover ∼19,000 deg2 visible from the Northern Hemisphere, reaching a z-band AB magnitude of ∼22.5. We use a deep residual neural network, trained on a compilation of known lensing systems and high-grade candidates as well as nonlenses in the same footprint. After applying our trained neural network to the survey data, we visually inspect and rank images with probabilities above a threshold which has been chosen to balance precision and recall. We have found 1895 lens candidates, of which 1512 are identified for the first time. Combining the discoveries from this work with those from Papers I (335) and II (1210), we have discovered a total of 3057 new candidates in the Legacy Surveys.