bluuebunny/crossref_metadata_2025_split huggingface dataset:
lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy
Authors: Li Xiangquan , Wang Hao , Yao Biao , Xu Weiting , Chen Jianchang , Zhou Xiang 
Published: October 2016

AbstractWe previously established a rat model of diabetic cardiomyopathy (DCM) and found that the expression of lncRNA H19 was significantly downregulated. The present study was designed to investigate the pathogenic role of H19 in the development of DCM. Overexpression of H19 in diabetic rats attenuated oxidative stress, inflammation and apoptosis, and consequently improved left ventricular function. High glucose was associated with reduced H19 expression and increased cardiomyocyte apoptosis. To explore the molecular mechanisms involved, we performed in vitro experiments using cultured neonatal rat cardiomyocytes. Our results showed that miR-675 expression was decreased in cardiomyocytes transfected with H19 siRNA. The 3′UTR of VDAC1 was cloned downstream of a luciferase reporter construct and cotransfected into HEK293 cells with miR-675 mimic. The results of luciferase assay indicated that VDAC1 might be a direct target of miR-675. The expression of VDAC1 was upregulated in cardiomyocytes transfected with miR-675 antagomir, which consequently promotes cellular apoptosis. Moreover, enforced expression of H19 was found to reduce VDAC1 expression and inhibit apoptosis in cardiomyocytes exposed to high glucose. In conclusion, our study demonstrates that H19/miR-675 axis is involved in the regulation of high glucose-induced apoptosis by targeting VDAC1, which may provide a novel therapeutic strategy for the treatment of DCM.
Single-Multiplex Detection of Organ Injury Biomarkers using SPRi based Nano-Immunosensor
Authors: Zeidan Effat , Li Siqi , Zhou Zhiguo , Miller Jennifer , Sandros Marinella G. 
Published: October 2016

AbstractThe clinical assessment of multiple organ dysfunctions at early stages is recognized to be an important factor in prompting definitive treatment decisions that prevent irreversible organ damage. In this article, we propose a real-time, label-free, and multiplex nanoenhanced SPRi platform to quantitatively assess two biomarkers, kidney injury molecule (KIM-1) and high mobility group box-1 (HMGB-1) simultaneously in buffer. Our work involves three major contributions in the design of the immunosensor: (1) we applied site-specific immobilization of antibodies to the solid surface that avoids loss of biological activity caused by covalent attachment; (2) we constructed a well-blocked sensor surface that exhibits minimal non-specific adsorption for singleplex measurements of each biomarker in buffer; and (3) we adopted a sandwich assay that implements functionalized quantum dots (NanoEnhancers) as signal amplifiers to achieve a sensitivity level of 5 pg/mL for KIM-1 and HMGB-1 in buffer. We foresee great potential and success in extending this multiplex and ultra-sensitive platform to assess a variety of other emerging clinical biomarkers at low concentrations and in complex matrices.
Introduction
Authors: David-Claude Kemo Keimbou , Emmanuel Claude Abolo Biwole , Maurice Enama 
Published: October 2016

Depuis le début des années 2010, on « commémore » le cinquantenaire des indépendances des pays d'Afrique noire francophone, de leurs armées, de leurs universités et grandes écoles, mais aussi de leur sport et mouvement sportif.
Politique juridique et diplomatie sportive du Cameroun de 1960 à nos jours : enjeux et mutations à l'ère de la mondialisation
Authors: Jabea Claude Bekombo 
Published: October 2016

Si l'organisation de ce qu'on peut appeler la communauté sportive internationale est structurée autour du « corporatisme sportif », les Etats, eux, sont marqués par la prégnance de la dualité « territoire » et « souveraineté ». C'est sous ce fondement binaire que l'Etat légifère sur le sport, on parle de politique juridique sportive et utilise le sport comme élément de sa diplomatie, on parle de diplomatie sportive. L'intérêt de cette étude est d'identifier les éléments constitutifs de la politique juridique et de la diplomatie sportive du Cameroun et In fine de donner des éléments permettant d'en parler de depuis l'indépendance.
Perception de la notion de litige sportif par les acteurs du mouvement sportif camerounais : entre et lueurs et leurres
Authors: Romuald Dey Yelem Franck 
Published: October 2016

Depuis sa création en 2001, la Chambre de Conciliation et d'Arbitrage (CCA) du Comité National Olympique et Sportif du Cameroun (CNOSC) n'avait jamais connu une aussi grande sollicitation en l'espace de quelques mois. En effet, la loi n∘ 2011/018 du 15 juillet 2011 relative à l'organisation et à la promotion des Activités Physiques et Sportives au Cameroun a davantage confirmé la place de cette juridiction sportive nationale au cœur du contentieux dans le domaine du sport.
La Chambre de conciliation et d'arbitrage est la seule juridiction sportive reconnue, au niveau national, par les lois camerounaises et aucune équivoque n'est levée dans cette loi sur la qualification du litige à soumettre devant la Chambre. Elle est compétente pour tous les litiges sportifs. Peut-être faudrait-il marquer un arrêt sur la notion de « litige sportif ». Si un contentieux électoral, au sein d'une fédération sportive, n'est pas un litige sportif, qu'elle est alors la nature d'un tel litige. Un tel litige n'est, ni commercial, ni politique, ni culturel, ni agricole. Il ne peut être que sportif, et de ce fait, relève de la compétence de la seule juridiction sportive légalement instituée.
L'intérêt de cette communication sera de donner le contenu des notions de litige sportif et contentieux électoral et les différentes positions en présence et voir comment les acteurs du mouvement sportif en ont fait une appréhension erronée. Il va aussi permettre à travers la jurisprudence qui est source de droit de trancher définitivement cette équivoque.
Le règlement des litiges sportifs devant la Chambre de Conciliation et d'Arbitrage – CCA CNOSC
Authors: Charles Tchatchouang M. 
Published: October 2016

Au cours de l'année 2011, un grand tournant de l'histoire du mouvement sportif camerounais a été marqué par l'adoption et la promulgation de la loi n∘ 2011/018 du 15 juillet 2011 relative à l'organisation et à la promotion des Activités Physiques et Sportives (A.P.S) au Cameroun. Cette loi qui abroge totalement celle n∘ 96/09 du 5 août 1996 fixant la Charte des APS illustre la volonté du législateur de réorganiser et de promouvoir ces activités au Cameroun. Elle vient en outre conforter la place de l'instrument juridique universel du mouvement sportif qu'est la Charte Olympique, laquelle institue des organes juridictionnels au sein des Comités Nationaux Olympiques (CNO). C'est la raison pour laquelle dans cette réorganisation, la Chambre de Conciliation et d'Arbitrage (CCA) occupe une place de choix. Plus qu'avant, plusieurs dispositions de ladite loi sont représentatives de cette affirmation.
Cette évolution juridique met un terme aux atermoiements affichés ou exprimés par certains membres du mouvement sportif camerounais qui de bonne ou de mauvaise foi, contestaient la légitimité et la compétence de la CCA.
L'intérêt de ce travail importe plus que jamais de présenter une vue d'ensemble des différentes mutations juridiques ayant marqué l'histoire de la Chambre de Conciliation et d'Arbitrage du Comité National Olympique et Sportif du Cameroun.
Football et unité nationale : entre construction politique et signification sociale (1965–2010)
Authors: Nassir Abdoun 
Published: October 2016

Au Cameroun, pays d'Afrique centrale qui compte plus de 200 langues nationales et entités ethniques, le football s'est imposé tant dans le discours politique que dans la praxis sociale comme un instrument de l'unité nationale. Sport le plus important au regard du palmarès et de l'engouement populaire, le football est un reflet pertinent de la dynamique historique qui s'opère dans ce pays. A l'image des clubs mythiques à base ethno-centrée qui ont animé la scène sportive du continent dans les décennies des années 60 et 70, la société semble s'attacher au marquage identitaire propre à ces associations sportives. C'est avec l'émergence du label « Lions indomptables » que nous assistons à un véritable mixage à l'échelle nationale. Dans une approche dynamique, il s'agit de déterminer les fondements de cette unité rendue opérationnelle par le football. L'approche est éminemment pluridisciplinaire en usant de l'histoire, de la science politique et de la sociologie.
Le mouvement olympique et les droits de l'homme
Authors: Enama Maurice 
Published: October 2016

L'histoire de l'olympisme moderne est traversée par la préoccupation lancinante et permanente du respect des droits de l'homme. Cela est heureux. En effet, les valeurs que véhicule l'olympisme sont peu ou prou « filles » des droits de l'homme, dans la mesure où ces valeurs puisent dans l'humanisme et dans l'universel.
L'Olympisme poursuit l'épanouissement total de l'individu pour une société plus ouverte, les Droits de l'Homme visent pour leur part la dignité l'Homme dans une société plus juste. Leur rapprochement paraît donc naturel dans une société humaine en proie aux égoïsmes, aux inégalités, aux discriminations de tous genres, en un mot à des forces négatrices et régressives.
L'Idéal olympique s'inscrit explicitement dans la perspective dessinée par la Convention Universelle des Droits de l'Homme. Les Droits de l'Homme sont ici pris dans leur aspect philosophique, tels qu'ils ont été théorisés par le juriste hongrois Alexandre-Charles Kiss (1991). Ils sont fondés sur le principe éthique de l' « égale dignité », cette expression elle-même empruntée au théoricien du droit Britannique Ronald Dworkin (1977). Avec ce principe les deux pendants de la dignité se rejoignent : la liberté positive qui représente la capacité pour chaque individu de décider de ce qui politiquement et socialement vaut pour l'homme et la liberté négative qui est celle de faire ce qui ne nuit pas à autrui. Ainsi donc, le principe « d'égale dignité » apparaît clairement comme la matrice de l'Olympisme et des Droits de l'Homme, même si ces dernières ont un spectre plus large.
Impact of increasing social media use on sitting time and body mass index
Authors: Alley Stephanie , Wellens Pauline , Schoeppe Stephanie , de Vries Hein , Rebar Amanda L. , Short Camille E. , Duncan Mitch J. , Vandelanotte Corneel 
Published: October 2016

Issue addressedSedentary behaviours, in particular sitting, increases the risk of cardiovascular disease, type 2 diabetes, obesity and poorer mental health status. In Australia, 70% of adults sit for more than 8 h per day. The use of social media applications (e.g. Facebook, Twitter, and Instagram) is on the rise; however, no studies have explored the association of social media use with sitting time and body mass index (BMI).MethodsCross‐sectional self‐report data on demographics, BMI and sitting time were collected from 1140 participants in the 2013 Queensland Social Survey. Generalised linear models were used to estimate associations of a social media score calculated from social media use, perceived importance of social media, and number of social media contacts with sitting time and BMI.ResultsParticipants with a high social media score had significantly greater sitting times while using a computer in leisure time and significantly greater total sitting time on non‐workdays. However, no associations were found between social media score and sitting to view TV, use motorised transport, work or participate in other leisure activities; or total workday, total sitting time or BMI.ConclusionsThese results indicate that social media use is associated with increased sitting time while using a computer, and total sitting time on non‐workdays.So what?The rise in social media use may have a negative impact on health by contributing to computer sitting and total sitting time on non‐workdays. Future longitudinal research with a representative sample and objective sitting measures is needed to confirm findings.
Medical Discovery as Suffrage Justification in Mary Putnam Jacobi’s 1894 New York Campaign Rhetoric
Authors: Skinner Carolyn 
Published: October 2016

AbstractThis article examines the suffrage rhetoric of nineteenth-century American physician Mary Putnam Jacobi. As a medical researcher, Putnam Jacobi believed that women’s participation in scientific research and their use of scientific arguments would improve the public’s perception of women, making woman suffrage more likely. As science grew in influence around the turn of the century, deploying its persuasive resources became an important part of both men’s and women’s social-issue rhetoric. This analysis of Putnam Jacobi’s suffrage rhetoric identifies two science-inflected arguments: first, she asserted that scientific findings had already prompted governments to be more inclusive, creating a science-driven model of social reform; second, she contended that women had met all the qualifications to vote, offering an empirical-evidence argument for suffrage.
“They Died the Spartan’s Death”: Thermopylae, the Alamo, and the Mirrors of Classical Analogy
Authors: Cox Jeremy 
Published: October 2016

ABSTRACTIn moments of crisis, people often make sense of the present by activating memories of the past through particular tropes of public memory. Classical analogies are one such trope, suggesting a sense of continuity between a (seemingly) stable ancient world and a chaotic present. Despite their prominence in American rhetoric, classical analogies have received too little attention from scholars of rhetoric. In the following, I interrogate the use of classical analogies in nineteenth-century American rhetoric— a period in which the classics were a vibrant aspect of public culture—by analyzing analogies between the fall of the Alamo and the fifth-century BC battle of Thermopylae. Thermopylae analogies were activated as tropes of public memory to warrant the formation of a defiant political identity for a Texian community reeling from defeat. Through an analysis of key texts that utilized Thermopylae analogies, I show that classical analogies sometimes go beyond comparisons between the past and the present to act as “mirrors” that inspire identification with, and imitation of, the ancients.
A Reevaluation of Alcuin’s Disputatio de rhetorica et de virtutibus as Consular Persuasion: The Context of the Late Eighth Century Revisited
Authors: Ramsey Shawn 
Published: October 2016

ABSTRACT
Alcuin’s Rhetoric possesses a singular relationship to the history of rhetoric and to its own unique historical period. The puzzlingly diverse evaluations of the Rhetoric’s purpose and “importance” are often clouded by the question of its subsequent historical influence. The purpose of the present argument is to present contextualizing information based on newly emerging historical data surrounding the mid-790s, the date of the Rhetoric’s composition, and its Augustinian influence. Alcuin’s Rhetoric is an early example of consular rhetoric to “advise the prince” that forms, in itself, a deliberative argument regarding a very specific set of historical exigencies that relate to legal policies toward unconverted subjects in the Carolingian empire. Alcuin’s motivation for the composition of the Rhetoric can be understood in the historically imminent adoption of the Saxon Code and its contradiction of the rhetorical counsel found in Augustine’s De Catechizandis Rudibus.
Predicting functional decline in older emergency patients—the Safe Elderly Emergency Discharge (SEED) project
Authors: Lowthian Judy A. , Straney Lahn D. , Brand Caroline A. , Barker Anna , Smit P. de Villiers , Newnham Harvey , Hunter Peter , Smith Cathie , Cameron Peter A. 
Published: October 2016

AbstractObjectiveto profile the trajectory of, and risk factors for, functional decline in older patients in the 30 days following Emergency Department (ED) discharge.Methodsprospective cohort study of community-dwelling patients aged ≥65 years, discharged home from a metropolitan Melbourne ED, 31 July 2012 to 30 November 2013. The primary outcome was functional decline, comprising either increased dependency in personal activities of daily living (ADL) or in skills required for living independently instrumental ADL (IADL), deterioration in cognitive function, nursing home admission or death. Univariate analyses were used to select risk factors and logistic regression models constructed to predict functional decline.Resultsat 30 days, 34.4% experienced functional decline; with 16.7% becoming more dependent in personal ADL, 17.5% more dependant in IADL and 18.4% suffering deterioration in cognitive function. Factors independently associated with decline were functional impairment prior to the visit in personal ADL (Odds Ratio [OR] 3.21, 95% confidence interval [CI] 2.26–4.53) or in IADL (OR 6.69, 95% CI 4.31–10.38). The relative odds were less for patients with moderately impaired cognition relative to those with normal cognition (OR 0.38, 95% CI 0.19–0.75). There was a 68% decline in the relative odds of functional decline for those with any impairment in IADL who used an aid for mobility (OR 0.32, 95% CI 0.14–0.7).Conclusionolder people with pre-existing ADL impairment were at high risk of functional decline in the 30 days following ED presentation. This effect was largely mitigated for those who used a mobility aid. Early intervention with functional assessments and appropriate implementation of support services and mobility aids could reduce functional decline after discharge.
Controlling the joint local false discovery rate is more powerful than meta-analysis methods in joint analysis of summary statistics from multiple genome-wide association studies
Authors: Jiang Wei , Yu Weichuan 
Published: October 2016

AbstractMotivationIn genome-wide association studies (GWASs) of common diseases/traits, we often analyze multiple GWASs with the same phenotype together to discover associated genetic variants with higher power. Since it is difficult to access data with detailed individual measurements, summary-statistics-based meta-analysis methods have become popular to jointly analyze datasets from multiple GWASs.ResultsIn this paper, we propose a novel summary-statistics-based joint analysis method based on controlling the joint local false discovery rate (Jlfdr). We prove that our method is the most powerful summary-statistics-based joint analysis method when controlling the false discovery rate at a certain level. In particular, the Jlfdr-based method achieves higher power than commonly used meta-analysis methods when analyzing heterogeneous datasets from multiple GWASs. Simulation experiments demonstrate the superior power of our method over meta-analysis methods. Also, our method discovers more associations than meta-analysis methods from empirical datasets of four phenotypes.Availability and ImplementationThe R-package is available at: http://bioinformatics.ust.hk/Jlfdr.html.Supplementary informationSupplementary data are available at Bioinformatics online.
Finding the imposter: brain connectivity of lesions causing delusional misidentifications
Authors: Darby R Ryan , Laganiere Simon , Pascual-Leone Alvaro , Prasad Sashank , Fox Michael D 
Published: October 2016

Abstract
See McKay and Furl (doi: 10.1093/aww323) for a scientific commentary on this article.
Focal brain injury can sometimes lead to bizarre symptoms, such as the delusion that a family member has been replaced by an imposter (Capgras syndrome). How a single brain lesion could cause such a complex disorder is unclear, leading many to speculate that concurrent delirium, psychiatric disease, dementia, or a second lesion is required. Here we instead propose that Capgras and other delusional misidentification syndromes arise from single lesions at unique locations within the human brain connectome. This hypothesis is motivated by evidence that symptoms emerge from sites functionally connected to a lesion location, not just the lesion location itself. First, 17 cases of lesion-induced delusional misidentifications were identified and lesion locations were mapped to a common brain atlas. Second, lesion network mapping was used to identify brain regions functionally connected to the lesion locations. Third, regions involved in familiarity perception and belief evaluation, two processes thought to be abnormal in delusional misidentifications, were identified using meta-analyses of previous functional magnetic resonance imaging studies. We found that all 17 lesion locations were functionally connected to the left retrosplenial cortex, the region most activated in functional magnetic resonance imaging studies of familiarity. Similarly, 16 of 17 lesion locations were functionally connected to the right frontal cortex, the region most activated in functional magnetic resonance imaging studies of expectation violation, a component of belief evaluation. This connectivity pattern was highly specific for delusional misidentifications compared to four other lesion-induced neurological syndromes (P &lt; 0.0001). Finally, 15 lesions causing other types of delusions were connected to expectation violation (P &lt; 0.0001) but not familiarity regions, demonstrating specificity for delusion content. Our results provide potential neuroanatomical correlates for impaired familiarity perception and belief evaluation in patients with delusional misidentifications. More generally, we demonstrate a mechanism by which a single lesion can cause a complex neuropsychiatric syndrome based on that lesion's unique pattern of functional connectivity, without the need for pre-existing or hidden pathology.
ArabidopsisMADS-box transcription factor AGL21 acts as environmental surveillance for seed germination by regulatingABI5
Authors: Yu Lin-Hui , Wu Jie , Miao Zi-Qing , Zhao Ping-Xia , Wang Zhen , Xiang Cheng-Bin 
Published: October 2016

ABSTRACTSeed germination is a crucial checkpoint for plant survival under unfavorable environmental conditions. Abscisic acid (ABA) and its signaling play a vital role in integrating environmental information to regulate seed germination. MCM1/AGAMOUS/DEFICIENS/SRF (MADS)-box transcription factors are mainly known as key regulators of seed and flower development inArabidopsis. However, their functions in seed germination are still poorly understood. Here we report that MADS-box transcription factor AGL21 negatively modulates seed germination and post-germination growth by controlling the expression ofABA-INSENSITIVE 5(ABI5) inArabidopsis. AGL21responds to multiple environmental stresses and plant hormones. TheAGL21-overexpressing plants are hypersensitive to ABA, salt and osmotic stresses during seed germination and early post-germination growth, whereasagl21mutants are less sensitive. AGL21 positively regulatesABI5expression in seeds. Genetic analyses reveal thatAGL21is epistatic toABI5in controlling seed germination. Chromatin immunoprecipitation assays further demonstrate that AGL21 could directly bind to theABI5promoter in plant cells. Taken together, our results suggest that AGL21 acts as a surveillance integrator that incorporates environmental cues and endogenous hormonal signals into ABA signaling to regulate seed germination and early post-germination growth.