bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of workplace incivility on service employee creativity: the mediating role of emotional exhaustion and intrinsic motivation
Authors: Hur Won-Moo , Moon Taewon , Jun Jea-Kyoon 
Published: May 2016

PurposeThis study aims to examine how workplace incivility (i.e. coworker and customer incivility) affects service employees’ creativity, specifically the way emotional exhaustion at work decreases their intrinsic motivation, and, in turn, damages service employees’ creativity. The purpose of this study, therefore, is to show the mechanism by which both coworker and customer incivility at work affects service employee creativity.Design/methodology/approachService employees from a hotel in South Korea were surveyed using a self-administered instrument for data collection. Out of 450 questionnaires, a total of 281 usable questionnaires were obtained after list-wise deletion, for a 62.4 per cent response rate. Structural equation modeling analysis provided support for the hypotheses.FindingsThe results indicate a serial multiple mediator model in which both coworker and customer incivility increase service employees’ emotional exhaustion, which, in turn, reduces their intrinsic motivation at work and ultimately decreases their creativity. That is, the findings of this study reveal a negative relationship between workplace incivility (i.e. coworker and customer incivility) and service employees’ creativity that is fully and sequentially mediated by the service employees’ emotional exhaustion and intrinsic motivation.Research limitations/implicationsThe use of cross-sectional self-reports potentially raises concerns about common method bias. Caution is recommended in reaching conclusions concerning the causal relationships between the variables, as the current study did not capture causality variation. For instance, it may be that emotional exhaustion from incivility gradually compounds over time, leading to a greater negative impact on service employees. In contrast, employees may develop strategies to cope with uncivil behavior over time, which attenuates the negative effects on service employees as time passes. A longitudinal design might offer an alternative to overcome this limitation in future research.Practical implicationsConsidering the findings about the mediating effect of emotional exhaustion between workplace incivility and employee outcomes (i.e. intrinsic motivation and creativity), firms should consider establishing systematic institutional practices and policies to prevent employees from feeling emotionally exhausted from workplace incivility. Executive and senior management teams would benefit by instituting strict policies and regulations which nurture desirable behaviors among organizational members that protect victims of workplace incivility.Originality/valueThis study is the first to examine the relationship between workplace incivility and creativity. Moreover, the present study attempts to develop an understanding of the underlying mechanism through which both coworker and customer incivility negatively affect service employees’ creativity.
How does customer orientation influence authentic emotional display?
Authors: Huang Yu-Shan (Sandy) , Brown Tom J. 
Published: May 2016

PurposeThe purpose of this paper is to examine how customer orientation affects frontline service workers’ deep acting and to what extent the effect is moderated by the severity of dysfunctional customer behavior (DCB). Service organizations usually want their employees to demonstrate sincere emotions during customer encounters.Design/methodology/approachThe study employed a mixed method design using measured variables (e.g. customer orientation) and a scenario-based manipulated variable (i.e. DCB severity). Data from 237 service workers were used to investigate the theoretical model.FindingsResults showed that perspective taking and emotional sensitivity mediate the positive effect of customer orientation on deep acting. Furthermore, the influence of emotional sensitivity on deep acting is positive when DCB is less severe, but becomes non-significant when DCB becomes severe.Research limitations/implicationsBecause the DCB severity is manipulated as a single event, future research can examine its influence based on employees’ experiences. Also, future studies may investigate other mechanisms to explain customer orientation’s effects on deep acting.Practical implicationsThis paper provides service organizations an understanding of the key roles of emotional sensitivity and perspective taking in driving deep acting as well as the importance of monitoring DCB severity.Originality/valueThe study is one of the first in marketing to examine the different influences of DCB severity on important employee outcomes. This study also identifies two important mediators to explain how customer orientation drives deep acting.
Determinants of customer price sensitivity: an empirical analysis
Authors: Dominique-Ferreira Sérgio , Vasconcelos Helder , Proença João F. 
Published: May 2016

PurposeConsumer price sensitivity has become a major issue over the past few decades. This paper aims to investigate the importance that insurance customers give to premiums, insurers, intermediary recommendations and bundling strategies. The relationship between attributes and consumer price sensitivity is also studied.Design/methodology/approachTo calculate the importance of attributes and part-worth utilities, a Conjoint Analysis with Full Profile was performed. To segment the market, a two-stage cluster analysis was performed. The traditional formula for estimating price elasticity of demand was also used.FindingsPrice sensitivity is affected by the level of purchase involvement, bundled discounts and brand loyalty. Also, brand loyalty has a strong influence on customer acceptance of bundled discounts. Price bundling increases a firm’s revenues and profits.Research limitations/implicationsThe size of the sample of the second stage of the research could be higher.It would also be interesting to have the collaboration of an actuary to carry out more precise analysis of premium estimation of bundling strategies and to study the ideal number of products that would compose the bundling strategy. Moreover, it could be relevant to consider life insurance products as part of the bundling strategy. It would also be interesting to study whether there is any benefit in applying the bundle discount to the anchor product instead of applying it to the accessory product.Practical implicationsInsurers and intermediaries can benefit from price bundling strategies to increase sales and profit.Originality/valueThe study contributes to the service marketing literature and marketing of the insurance sector by providing empirical evidence of the impact of price bundling on insurance customer sensitivity, with the use of a methodological and experimental approach.
Timing of earnings restatements: CEO equity compensation and market reaction
Authors: BenYoussef Nourhene , Khan Saqib 
Published: May 2016

AbstractThis study investigates the impact of chief executive officers’ (CEO) compensation on their choices regarding the timing of earnings restatements. The results indicate a negative relationship between options exercised and lags in disclosing the restated earnings, suggesting that managers who exercise options in a given year tend to release information quickly. This effect is more pronounced if the options are exercised after the dark period. We also find that the market penalises longer lags in the restatement disclosure. It seems that the CEO would try to optimise the timing of information release so as to balance the costs and benefits.
A novel molecular disease classifier for psoriasis and eczema
Authors: Garzorz‐Stark Natalie , Krause Linda , Lauffer Felix , Atenhan Anne , Thomas Jenny , Stark Sebastian P. , Franz Regina , Weidinger Stephan , Balato Anna , Mueller Nikola S. , Theis Fabian J. , Ring Johannes , Schmidt‐Weber Carsten B. , Biedermann Tilo , Eyerich Stefanie , Eyerich Kilian 
Published: May 2016

AbstractNovel specific therapies for psoriasis and eczema have been developed, and they mark a new era in the treatment of these complex inflammatory skin diseases. However, within their broad clinical spectrum, psoriasis and eczema phenotypes overlap making an accurate diagnosis impossible in special cases, not to speak about predicting the clinical outcome of an individual patient. Here, we present a novel robust molecular classifier (MC) consisting of NOS2 and CCL27 gene that diagnosed psoriasis and eczema with a sensitivity and specificity of >95% in a cohort of 129 patients suffering from (i) classical forms; (ii) subtypes; and (iii) clinically and histologically indistinct variants of psoriasis and eczema. NOS2 and CCL27 correlated with clinical and histological hallmarks of psoriasis and eczema in a mutually antagonistic way, thus highlighting their biological relevance. In line with this, the MC could be transferred to the level of immunofluorescence stainings for iNOS and CCL27 protein on paraffin‐embedded sections, where patients were diagnosed with sensitivity and specificity >88%. Our MC proved superiority over current gold standard methods to distinguish psoriasis and eczema and may therefore build the basis for molecular diagnosis of chronic inflammatory skin diseases required to establish personalized medicine in the field.
Combined Effect of Drought Stress and Elevated Atmospheric CO2 Concentration on the Yield Parameters and Water Use Properties of Winter Wheat (Triticum aestivum L.) Genotypes
Authors: Varga B. , Vida G. , Varga‐László E. , Hoffmann B. , Veisz O. 
Published: May 2016

AbstractThe decline in the amount of water available to plants will lend growing importance to the dynamics of water uptake and to water use efficiency (WUE; g kg−1) in cereals. Water use properties were investigated in terms of the phenological and yield parameters of five winter wheat genotypes in a greenhouse experiment carried out in climate‐controlled chambers. The plants were grown either with optimum water supplies or with simulated drought in two phenophases, combined with different CO2 concentrations (ambient and enriched to 700 and 1000 ppm). Multivariate analysis showed that the CO2 concentration alone significantly influenced water use and water use efficiency but in combination with the cultivars, it also had a significant influence on the grain yield and in a combination with the water supply on the straw biomass, respectively. Higher CO2 concentration significantly reduced the water uptake and improved the WUE values in both the drought treatments. All three factors investigated were found to have a significant influence on the water consumption during the growing season, and the interaction between CO2 and the cultivar influenced WUE. The least change in WUE was detected for Bánkúti 1201 (1.35–1.86 g kg−1), while Mv Mambó, Plainsman V and Mv Toborzó formed a group responding similarly to various environmental effects (1.85–2.55 g kg−1; 1.57–2.34 g kg−1 and 1.45–2.24 g kg−1, respectively).
Exchange Rate Flexibility and the Effect of Remittances on Economic Growth
Authors: Lartey Emmanuel K. K. 
Published: May 2016

AbstractThis paper studies the question of whether exchange rate policy affects the impact of remittances on economic growth in recipient countries. The findings indicate that more flexible exchange rate regimes are associated with a greater increase in economic growth following an increase in remittances, but also that the impact of remittances on growth is positive under a fixed regime. The results further show that the effect of remittances under a fixed exchange rate regime is positive in less financially developed countries as well, but do not provide conclusive evidence that this effect varies inversely with exchange rate flexibility in such economies as theorized; the results being sensitive to the choice of financial development indicator.
Mosaic H5 Hemagglutinin Provides Broad Humoral and Cellular Immune Responses against Influenza Viruses
Authors: Kamlangdee Attapon , Kingstad-Bakke Brock , Osorio Jorge E. 
Published: May 2016

ABSTRACTThe most effective way to prevent influenza virus infection is via vaccination. However, the constant mutation of influenza viruses due to antigenic drift and shift compromises vaccine efficacy. This represents a major challenge to the development of a cross-protective vaccine that can protect against circulating viral antigenic diversity. Using the modified vaccinia Ankara (MVA) virus, we had previously generated a recombinant vaccine against highly pathogenic avian influenza virus (H5N1) based on anin silicomosaic approach. This MVA-H5M construct protected mice against multiple clades of H5N1 and H1N1 viruses. We have now further characterized the immune responses using immunodepletion of T cells and passive serum transfer, and these studies indicate that antibodies are the main contributors in homosubtypic protection (H5N1 clades). Compared to a MVA construct expressing hemagglutinin (HA) from influenza virus A/VN/1203/04 (MVA-HA), the MVA-H5M vaccine markedly increased and broadened B cell and T cell responses against H5N1 virus. The MVA-H5M also provided effective protection with no morbidity against H5N1 challenge, whereas MVA-HA-vaccinated mice showed clinical signs and experienced significant weight loss. In addition, MVA-H5M induced CD8+T cell responses that play a major role in heterosubtypic protection (H1N1). Finally, expression of the H5M gene as either a DNA vaccine or a subunit protein protected mice against H5N1 challenge, indicating the effectiveness of the mosaic sequence without viral vectors for the development of a universal influenza vaccine.IMPORTANCEInfluenza viruses infect up to one billion people around the globe each year and are responsible for 300,000 to 500,000 deaths annually. Vaccines are still the main intervention to prevent infection, but they fail to provide effective protection against heterologous strains of viruses. We developed broadly reactive H5N1 vaccine based on anin silicomosaic approach and previously demonstrated that modified vaccinia Ankara expressing an H5 mosaic hemagglutinin prevented infection with multiple clades of H5N1 and limited severe disease after H1N1 infection. Further characterization revealed that antibody responses and T cells are main contributors to protection against H5N1 and H1N1 viruses, respectively. The vaccine also broadens both T cell and B cell responses compared to native H5 vaccine from influenza virus A/Vietnam/1203/04. Finally, delivering the H5 mosaic as a DNA vaccine or as a purified protein demonstrated effective protection similar to the viral vector approach.
Intrathecal hyperbaric versus isobaric bupivacaine for adult non-caesarean-section surgery: systematic review protocol
Authors: Uppal Vishal , Shanthanna Harsha , Prabhakar Christopher , McKeen Dolores M 
Published: May 2016

IntroductionBupivacaine is the most commonly used local anaesthetic for spinal anaesthesia (SA). There are two forms of commercially available bupivacaine; isobaric bupivacaine (IB): a formulation with a specific gravity or density equal to cerebrospinal fluid, and hyperbaric bupivacaine (HB): a formulation with density heavier than cerebrospinal fluid. The difference in densities of the two available preparations is believed to affect the diffusion pattern that determines the effectiveness, spread and side-effect profile of bupivacaine. This systematic review will summarise the best available evidence regarding the effectiveness and safety on the use of HB compared with IB, when used to provide SA for surgery. Primarily, we will analyse the need for conversion to general anaesthesia. As secondary outcomes, we will compare the incidence of hypotension, incidence of nausea/vomiting, the onset time and duration of anaesthesia.Methods and analysisWe will search key electronic databases using search strategy (1) injections, spinal OR intrathecal OR subarachnoid; (2) bupivacaine OR levobupivacaine; (3) hypobaric OR isobaric OR plain; (4) baricity. We will search MEDLINE, EMBASE and Cochrane databases, from their inception for randomised controlled trials, with no restrictions on language. Caesarean section surgery will be excluded. 2 reviewers will independently extract the data using a standardised form. Extracted items will include study characteristics, risk of bias domains, as per modified Cochrane risk of bias, participant disposition and study outcomes. We will conduct a meta-analysis for variables that can be compared across the studies. We will evaluate clinical heterogeneity by qualitatively appraising differences in study characteristics in participants, interventions and the outcomes assessed. We will report our findings as relative risks (dichotomous), and weighted mean differences (continuous) for individual outcomes, along with their 95% CIs.Ethics and disseminationWe plan to submit, and will publish, our findings in a peer-reviewed scientific journal, and present our results at national and international meetings.Trial registration numberCRD42015017672.
Measuring patient-perceived quality of care in US hospitals using Twitter
Authors: Hawkins Jared B , Brownstein John S , Tuli Gaurav , Runels Tessa , Broecker Katherine , Nsoesie Elaine O , McIver David J , Rozenblum Ronen , Wright Adam , Bourgeois Florence T , Greaves Felix 
Published: May 2016

BackgroundPatients routinely use Twitter to share feedback about their experience receiving healthcare. Identifying and analysing the content of posts sent to hospitals may provide a novel real-time measure of quality, supplementing traditional, survey-based approaches.ObjectiveTo assess the use of Twitter as a supplemental data stream for measuring patient-perceived quality of care in US hospitals and compare patient sentiments about hospitals with established quality measures.Design404 065 tweets directed to 2349 US hospitals over a 1-year period were classified as having to do with patient experience using a machine learning approach. Sentiment was calculated for these tweets using natural language processing. 11 602 tweets were manually categorised into patient experience topics. Finally, hospitals with ≥50 patient experience tweets were surveyed to understand how they use Twitter to interact with patients.Key resultsRoughly half of the hospitals in the US have a presence on Twitter. Of the tweets directed toward these hospitals, 34 725 (9.4%) were related to patient experience and covered diverse topics. Analyses limited to hospitals with ≥50 patient experience tweets revealed that they were more active on Twitter, more likely to be below the national median of Medicare patients (p<0.001) and above the national median for nurse/patient ratio (p=0.006), and to be a non-profit hospital (p<0.001). After adjusting for hospital characteristics, we found that Twitter sentiment was not associated with Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) ratings (but having a Twitter account was), although there was a weak association with 30-day hospital readmission rates (p=0.003).ConclusionsTweets describing patient experiences in hospitals cover a wide range of patient care aspects and can be identified using automated approaches. These tweets represent a potentially untapped indicator of quality and may be valuable to patients, researchers, policy makers and hospital administrators.
Osimertinib (AZD9291) Enhanced the Efficacy of Chemotherapeutic Agents in ABCB1- and ABCG2-Overexpressing Cells In Vitro, In Vivo, and Ex Vivo
Authors: Chen Zhen , Chen Yifan , Xu Meng , Chen Likun , Zhang Xu , To Kenneth Kin Wah , Zhao Hongyun , Wang Fang , Xia Zhongjun , Chen Xiaoqin , Fu Liwu 
Published: May 2016

Abstract
The overexpression of ATP-binding cassette (ABC) transporters has been proved to be a major trigger for multidrug resistance (MDR) in certain types of cancer. In our study, we investigated whether osimertinib (AZD9291), a third-generation irreversible tyrosine kinase inhibitor of both activating EGFR mutations and resistance-associated T790M point mutation, could reverse MDR induced by ABCB1 and ABCG2 in vitro, in vivo, and ex vivo. Our results showed that osimertinib significantly increased the sensitivity of ABCB1- and ABCG2-overexpressing cells to their substrate chemotherapeutic agents in vitro and in the model of ABCB1-overexpressing KBv200 cell xenograft in nude mice. Mechanistically, osimertinib increased the intracellular accumulations of doxorubicin (DOX) and Rhodamine 123 (Rho 123) by inhibiting the efflux function of the transporters in ABCB1- or ABCG2-overexpressing cells but not in their parental sensitive cells. Furthermore, osimertinib stimulated the ATPase activity of both ABCB1 and ABCG2 and competed with the [125I] iodoarylazidoprazosin photolabeling bound to ABCB1 or ABCG2, but did not alter the localization and expression of ABCB1 or ABCG2 in mRNA and protein levels nor the phosphorylations of EGFR, AKT, and ERK. Importantly, osimertinib also enhanced the cytotoxicity of DOX and intracellular accumulation of Rho 123 in ABCB1-overexpressing primary leukemia cells. Overall, these findings suggest osimertinib reverses ABCB1- and ABCG2-mediated MDR via inhibiting ABCB1 and ABCG2 from pumping out chemotherapeutic agents and provide possibility for cancer combinational therapy with osimertinib in the clinic. Mol Cancer Ther; 15(8); 1845–58. ©2016 AACR.
Evidence for potential involvement of pro-inflammatory adipokines in the pathogenesis of idiopathic intracranial hypertension
Authors: Samancı Bedia , Samancı Yavuz , Tüzün Erdem , Altıokka-Uzun Güneş , Ekizoğlu Esme , İçöz Sema , Şahin Erdi , Küçükali Cem İsmail , Baykan Betül 
Published: May 2016

BackgroundAlthough specific role players are currently unknown, contribution of inflammatory mediators has been suggested in the pathophysiology of idiopathic intracranial hypertension (IIH), which is a disease more prevalent in obese female individuals of childbearing age. We aimed to investigate the levels of adipokines and cytokines to demonstrate possible markers for inflammation that participate in IIH pathophysiology and their association with clinical features of IIH.MethodsIIH patients, diagnosed according to the revised criteria, and age-, gender- and body mass index (BMI)-matched healthy controls were enrolled in this study. Serum samples were evaluated for insulin-like growth factor 1, insulin, nesfatin, adiponectin, interleukin (IL)-1β, IL-6, IL-8, leptin, plasminogen activator inhibitor type-1, resistin, tumour necrosis factor-alpha (TNF-α) and monocyte chemotactic protein 1 via enzyme-linked immunosorbent assay or multiplex immunoassays.ResultsIL-1β level was significantly higher ( p = 0.012), and IL-8 and TNF-α levels were significantly lower in the IIH group ( p < 0.001 and p = 0.008, respectively) compared to the control group. There were no correlations between the cytokine/adipokine levels and age, BMI, disease duration, and cerebrospinal fluid oligoclonal bands. There were also no significant differences in cytokine and adipokine levels between IIH patients regarding visual impairment. However, statistically significant differences were found between IIH patients with relapse versus healthy controls regarding IL-1β ( p = 0.007), IL-8 ( p = 0.001) and TNF-α ( p = 0.017) levels. Other investigated cytokines and adipokines showed no significant alterations in IIH patients investigated in the remission period.ConclusionAltered serum levels of IL-1β, IL-8 and TNF-α seem to be associated with IIH pathogenesis, and these cytokines may be used as prognostic markers in IIH to predict relapse.