bluuebunny/crossref_metadata_2025_split huggingface dataset:
Persistence of Triploid Grass Carp in Devils Lake, Oregon
Authors: Clemens Benjamin J. , Spangler John J. , Robertson Paul L. , Galovich Gary M. , Banner Craig R. , Gunckel Stephanie L. , Ketchum Lindsay L. , Bowden R. Kanani , Spagnoli Sean T. , Kent Michael L. , Kirk James P. 
Published: April 2016

Abstract
Grass carp Ctenopharyngodon idella are sometimes used as a biological tool for managing aquatic vegetation in reservoirs. Sterile, triploid fish were stocked in Devils Lake, Oregon, during 1986, 1987, and 1993 to control aquatic vegetation. We present a case study for using multiple measures on the same fish to determine whether illegal stocking of fertile, diploid grass carp occurred. An investigation into the estimated age of a dead grass carp found in Devils Lake suggested that it was significantly younger than would otherwise be expected, given the only stocking events occurred during 1986, 1987, and 1993. To determine whether illegal stocking or reproduction by presumed sterile grass carp had occurred in Devils Lake, we conducted a study that balanced the needs of lethally sampling grass carp for biological measures with the socially and politically sensitive sentiment of the pro–grass carp citizenry of Devils Lake. These considerations, in combination with a low catch per-unit effort, resulted in a modest sample size for grass carp. We sampled grass carp and recorded multiple measures for each fish. Ploidy testing of blood samples indicated the grass carp were all triploid. Based on gonadal histopathology, six fish were male, two were female, and two were sex-indeterminate with severe gonadal dysgenesis. Age estimates from lapillus otoliths were consistent with fish originating from the legal stocking events in Devils Lake. The grass carp were 21–30 y old, and we were unable to find published reports of grass carp anywhere else in the world that are older. The grass carp were significantly smaller than much younger fish from other regions. The small size of these grass carp relative to their age in Devils Lake suggests food limitations that stunted growth. The dead grass carp that was the impetus for this study was aged by anatomical structures that we have since found to be unreliable. This suggests that the dead grass carp was probably in fact older and originated from the legal stockings. The use of multiple biological measurements on a modest sample size of grass carp, combined with the knowledge that no juvenile grass carp have been observed since legal stocking occurred, lead us to conclude that the grass carp in Devils Lake are sterile fish that originated from legal stocking events.
Environmental Immunology: Lessons Learned from Exposure to a Select Panel of Immunotoxicants
Authors: Kreitinger Joanna M. , Beamer Celine A. , Shepherd David M. 
Published: April 2016

Abstract
Exposure to environmental contaminants can produce profound effects on the immune system. Many classes of xenobiotics can significantly suppress or enhance immune responsiveness depending on the levels (i.e., dose) and context (i.e., timing, route) of exposure. Although defining the effects that toxicants can have on the immune system is a valuable component to improving public health, environmental immunology has greatly enhanced our understanding of how the immune system functions and has provided innovative avenues to explore new immunotherapies. This Brief Review focuses on three examples of how immunotoxicology has benefitted the field of immunology, presenting information on the aryl hydrocarbon receptor signaling pathway, the immunomodulatory effects of nanomaterials, and the impact of xenobiotic exposure on the developing immune system. Collectively, contributions from immunotoxicology have significantly enhanced public health and spurred seminal advances in both basic and applied immunology.
Multiple primary cancers: An enigma
Authors: Jena Amitabh , Patnayak Rashmi , Lakshmi Amancharla Yadagiri , Manilal Banoth , Reddy Mandyam Kumaraswamy 
Published: April 2016

Abstract
Background: Incidence of multiple primary cancers though uncommon, is being frequently reported now-a-days owing to better diagnostic techniques, the prolonged life span and the increased incidence of long-term survival of cancer patients. Materials and Methods: This is a retrospective study. Cases of multiple malignancies diagnosed histopathologically were retrieved from the archives of department of surgical oncology. Clinical data were obtained from the medical records. They were categorized as synchronous malignancies if the interval between them was less or equal to 6 months and metachronous, if the interval was more than 6 months. Results: A total of 13 cases were encountered in the 5 year study period. Out of them two were in the metachronous category and the rest were synchronous as the 2nd malignancy was detected mostly during clinical evaluation of the patients for the primary malignancy. There was female predominance with age range being 43-68 years. Majority of the cases were in the 7th decade. The most common organ involved was breast, followed by cervix. Apart from bilateral breast malignancies, there were combinations like breast with uterine endometrial carcinoma, cervical carcinoma and even papillary thyroid carcinoma. Conclusion: Detection of multiple primary malignancies is becoming increasingly common in day-to-day practice. Greater awareness of this is required among both cancer patients and their treating clinicians.
Simultaneous Treatment with Subcutaneous Injection of Golimumab and Intra-articular Injection of Triamcinolone Acetonide (K-Method) in Patients with Rheumatoid Arthritis Undergoing Switching of Biologics: Retrospective Case–Control Study
Authors: Kanbe Katsuaki , Chiba Junji , Inoue Yasuo , Taguchi Masashi , Yabuki Akiko , Deguchi Tomohiko 
Published: April 2016

Background Tight control of severe rheumatoid arthritis (RA) in patients with high disease activity, even when using biologics, is sometimes difficult using a treat-to-target strategy. Switching from one biologic to another is associated with lower efficacy than that in treatment-naive cases. We developed the K-method that involves simultaneous treatment with golimumab and intra-articular joint injection of triamcinolone acetonide (TA) in patients undergoing switching of biologics. We performed this retrospective case–control study to investigate the efficacy of achieving an immediate treatment response using the K-method. Methods This study involved 20 patients with RA (control group, 10 patients; K-method group, 10 patients). Patients in the control group were switched to golimumab from other biologics without intra-articular injection of TA. The K-method involved injection of 1 mL of TA (40 mg/mL) and 2 mL of 1% lidocaine hydrochloride into swollen or painful joints on the same day as golimumab treatment. A quick response one day after treatment was compared between the two groups according to the disease activity score 28 based on C-reactive protein (DAS28 CRP), clinical disease activity index (CDAI), simplified disease activity index (SDAI), European League Against Rheumatism (EULAR) response, and remission rate. These parameters were investigated for 24 weeks. Results The K-method group showed significant improvements in DAS28 CRP, CDAI, and SDAI at one day, 12 weeks, and 24 weeks compared with the control group. The number of swollen and tender joints and the patient and doctor global visual analog scale scores were also significantly different between the two groups. The remission rates based on DAS28 CRP were 30% at one day, 50% at 12 weeks, and 60% at 24 weeks in the K-method group. The EULAR good/moderate response rates were 80% at one day, 90% at 12 weeks, and 90% at 24 weeks in the K-method group; however, these rates were only 10%, 40%, and 40%, respectively, in the control group. No adverse events occurred in either group. Conclusion Simultaneous treatment with biologics and intra-articular injection of TA is useful for cases involving switching of biologics for RA. This strategy is safe and practical for RA treatment.
Effectiveness of Interventions to Address Visual and Visual–Perceptual Impairments to Improve Occupational Performance in Adults With Traumatic Brain Injury: A Systematic Review
Authors: Berger Sue , Kaldenberg Jennifer , Selmane Romeissa , Carlo Stephanie 
Published: April 2016

Abstract
OBJECTIVE. Visual and visual–perceptual impairments occur frequently with traumatic brain injury (TBI) and influence occupational performance. This systematic review examined the effectiveness of interventions within the scope of occupational therapy to improve occupational performance for adults with visual and visual–perceptual impairments as a result of TBI.
METHOD. Medline, PsycINFO, CINAHL, OTseeker, and the Cochrane Database of Systematic Reviews were searched, and 66 full text articles were reviewed. Sixteen articles were included in the review.
RESULTS. Strong evidence supports the use of scanning, limited evidence supports the use of adaptive strategies, and mixed evidence supports the use of cognitive interventions to improve occupational performance for adults with TBI. Evidence related to vision therapy varies on the basis of the specific intervention implemented.
CONCLUSION. Although the strength of the research varied, implications are discussed for practice, education, and research.
Changes in Upper-Extremity Functional Capacity and Daily Performance During Outpatient Occupational Therapy for People With Stroke
Authors: Doman Caitlin A. , Waddell Kimberly J. , Bailey Ryan R. , Moore Jennifer L. , Lang Catherine E. 
Published: April 2016

Abstract
OBJECTIVE. This study explored how upper-extremity (UE) functional capacity and daily performance change during the course of outpatient rehabilitation in people with stroke.
METHOD. Fifteen participants receiving outpatient occupational therapy services for UE paresis poststroke were enrolled. UE motor capacity was measured with the Action Research Arm Test (ARAT), and UE performance was measured using bilateral, wrist-worn accelerometers. Measurements were taken at or near the start of therapy, at every 10th visit or every 30 days throughout the duration of services, and at discharge.
RESULTS. Three patterns were observed: (1) increase in ARAT scores and more normalized accelerometry profiles, (2) increase in ARAT scores but no change in accelerometry profiles, and (3) no change in ARAT scores or in accelerometry profiles.
CONCLUSION. UE performance in daily life was highly variable, with inconsistencies between change in UE capacity and change in UE performance. UE capacity and performance are important constructs to assess separately during rehabilitation.
A Lagrangian description on the troposphere-to-stratosphere transport changes associated with the stratospheric water drop around the year 2000
Authors: Hasebe Fumio , Noguchi Taisuke 
Published: April 2016

Abstract. The sudden decrease in stratospheric water vapor at around the year 2000 to 2001 is relatively well accepted in spite of the difficulty to quantify the long-term variations. This stepwise change is studied by examining the entry value of water to the stratosphere ([H2O]e) and some Lagrangian diagnostics of dehydration taking place in the tropical tropopause layer (TTL). The analysis is made using the backward kinematic trajectories initialized every  ∼ 10 days from January 1997 to December 2002 at 400 K potential temperature surface in the tropics. The [H2O]e is estimated by the ensemble mean value of the water saturation mixing ratio (SMR) at the Lagrangian cold point (LCP) where SMR becomes minimum (SMRmin) in the TTL before reaching the 400 K surface. The drop in [H2O]e is identified to have occurred in September 2000. The horizontal projection of September trajectories, tightly trapped by anticyclonic circulation around the Tibetan high, shows eastward expansion since the year 2000. Associated changes are measured by three-dimensional bins, each having the dimension of 10° longitude by 10° latitude within the TTL. The probability distribution of LCPs shows an appreciable change exhibiting a composite pattern of two components: (i) the dipole structure consisting of the decrease over the Bay of Bengal and Malay Peninsula and the increase over the northern subtropical western Pacific and (ii) the patterns of the decrease over the equatorial western Pacific and the increase over the central Pacific that are almost symmetric with respect to the Equator. The SMRmin shows a general decrease in the tropics with some enhancement in the central Pacific. The expectation values, defined by the multiple of the probability of LCP events and the ensemble mean values of SMRmin, are calculated on each bin for both periods prior and posterior to the drop. These values are the spatial projection of [H2O]e on an individual bin. The results indicate that the drop is brought about by the decrease in water transport borne by the air parcels that have experienced the LCP over the Bay of Bengal and the western tropical Pacific. The former is related to the eastward expansion of the anticyclonic circulation around the weakened Tibetan high, while the latter would be linked to the eastward expansion of western tropical warm water to the central Pacific. This oceanic surface forcing may be responsible also for the modulation of dehydration efficiency in the successive northern winter. The drop in September 2000 and the sustained low values thereafter of [H2O]e are thus interpreted as being driven by the changes in thermal forcing from the continental and oceanic bottom boundaries.
The Role of Computed Tomography in the Immediate Workup of Open Globe Injury
Authors: Allon Gilad , Beiran Itzhak , Seider Nir , Blumenthal Eytan Z. 
Published: April 2016

Purpose Immediate primary closure is indicated in cases of traumatic open globe injury. Orbital computed tomography (CT) is performed prior to primary closure in order to rule out possible intraocular foreign bodies (IOFB) and/or damage to adjacent extraocular as well as intraocular structures. The aim of the present study is to evaluate the yield of orbital CT scan in immediate clinical decision-making in cases of open globe injury. Methods All cases of open globe injury treated in our institute during a 10-year period were reviewed. All underwent a CT scan before any surgical intervention, regardless of trauma severity. The influence of the CT scan results on decisions regarding the immediate treatment of the open globe injury was analyzed. Results A total of 125 cases of open globe injury were included in the present study. In none of these cases did the CT scan results have any influence on immediate treatment. The CT scan results did influence decisions that were made after the immediate operative stage. Conclusions Computed tomography scan has limited value in immediate clinical decision-making in cases of open globe injury scheduled for primary closure. While not crucial prior to the initial procedure, it is of value in managing the case during the following few days as well as later on. This study suggests that a CT scan performed after the initial globe exploration and suturing procedure is a valid alternative to stalling the definite globe suturing process until a CT scan is obtained and interpreted.
Our Early Experience of the Corin Minihip Prosthesis
Authors: Teoh Kar H. , Lee Paul Y.F. , Woodnutt David J. 
Published: April 2016

Purpose Although there have been several varieties of short-stem hip prosthesis in the market, there have been no published clinical results of the Corin MiniHip (Corin, Cirencester, UK) to date. The aim of this study is to describe our early results and experience of this stem in a nondesigner, single-surgeon series; calculate 5-year survival with stem revision as an endpoint; evaluate complications and early revisions; and assess radiolucency and stem subsidence at the latest follow-up review. Methods Over a 5-year period, 275 MiniHip were implanted in 239 patients. The mean age of the patients was 63 years (range 20-84); mean follow-up was 37 months (range 12-72 months). Results The mean Harris Hip Score and Oxford Hip Score improved significantly to 87 (range 49-100) and 41 (range 32-48) at the final follow-up (p = 0.038; p = 0.017). There were 9 intraoperative calcar fractures (3%) of which only 1 required cerlage wiring. 10 patients died in our series and none were lost to follow-up. 2 patients had their stem revised for failure of fixation (secondary to possible undersizing) and sink. The risk of revision was 0.73% at 5 years. The Kaplan Meier estimate of survivorship of cumulative failure gave an implant survival rate of 99.3% (95% confidence interval [CI], 27.0-100) at 5 years for revision for any reason as the endpoint. Conclusions This novel, short-stem prosthesis has shown good survival in the short term, similar to other short-stem prostheses currently available. We describe the largest series in the literature of this prosthesis.
Reliability in the Diagnosis of Femoroacetabular Impingement and Dysplasia Among HIP Surgeons: Role of Surgeon Volume and Experience
Authors: Malviya Ajay , Raza Ali , Witt Johan D. 
Published: April 2016

Purpose To evaluate the degree of inter-rater agreement in identifying important radiographic features of femoroacetabular impingement (FAI) and hip dysplasia. In addition, the effect of supplementary investigations (CT and/or MRI) and clinical experience of the observer was determined. Methods During the British Hip Society meeting 2013 participants were asked to remark on various radiological parameters of FAI and dysplasia, make a diagnosis, and recommended treatment. Free-Marginal Multirater Kappa analysis was performed to determine multi-rater agreement. Results The ‘crossover sign’, ‘ischial spine sign’ and ‘lateral centre-edge angle’ were found to have the highest inter-rater agreement. For the whole group only fair agreement was seen for the diagnosis of type of FAI ( κ = 0.3) and dysplasia ( κ = 0.3) after plain radiographs with supplementary investigations being only marginally helpful in improving the diagnosis of type of FAI ( κ = 0.4). In contrast, high-volume hip preservation surgeons had a substantial improvement in diagnosis after supplementary investigations (type of FAI κ = 0.75, and dysplasia ( κ = 0.65). Conclusions Our study shows that agreement on diagnosis and treatment on the basis of plain radiographs is low amongst general hip surgeons. This improved with surgeon volume and experience, suggesting that protocols for diagnosis of these conditions need to be altered as assessment appears to be rather subjective.
A New Approach for Semiempirical Modeling of Mechanical Blood Trauma
Authors: Poorkhalil Ali , Amoabediny Ghassem , Tabesh Hadi , Behbahani Mehdi , Mottaghy Khosrow 
Published: April 2016

Purpose Two semi-empirical models were recently published, both making use of existing literature data, but each taking into account different physical phenomena that trigger hemolysis. In the first model, hemoglobin (Hb) release is described as a permeation procedure across the membrane, assuming a shear stress-dependent process (sublethal model). The second model only accounts for hemoglobin release that is caused by cell membrane breakdown, which occurs when red blood cells (RBC) undergo mechanically induced shearing for a period longer than the threshold time (nonuniform threshold model). In this paper, we introduce a model that considers the hemolysis generated by both these possible phenomena. Methods Since hemolysis can possibly be caused by permeation of hemoglobin through the RBC functional membrane as well as by release of hemoglobin from RBC membrane breakdown, our proposed model combines both these models. An experimental setup consisting of a Couette device was utilized for validation of our proposed model. Results A comparison is presented between the damage index (DI) predicted by the proposed model vs. the sublethal model vs. the nonthreshold model and experimental datasets. This comparison covers a wide range of shear stress for both human and porcine blood. An appropriate agreement between the measured DI and the DI predicted by the present model was obtained. Conclusions The semiempirical hemolysis model introduced in this paper aims for significantly enhanced conformity with experimental data. Two phenomenological outcomes become possible with the proposed approach: an estimation of the average time after which cell membrane breakdown occurs under the applied conditions, and a prediction of the ratio between the phenomena involved in hemolysis.
The Effect of Portfolio-Based Assessment on Jordanian EFL Learners’ Writing Performance
Authors: Obeiah Salameh F. , Bataineh Ruba Fahmi 
Published: April 2016

This study examines the effect of portfolio assessment on Jordanian EFL tenth grade learners’ overall writing performance and their performance on the sub-skills of focus, development, organization, conventions and word choice. The study is quasi-experimental in which an experimental group and a control group of 20 students each were purposefully drawn from tenth grade classes at the public schools for girls in the North-Eastern Badia Directorate of Education. The experimental group was instructed on how to generate ideas, structure, draft, and edit their written pieces following Hamp-Lyons and Condon’s (2000) while the control group was instructed conventionally as prescribed in the Teacher’s Book. The findings revealed that the portfolio group outperformed the conventionally instructed group (at a≤ 0.05) in their overall writing performance and in their performance on the writing sub-skills of focus, development, organization, conventions and word choice.
Las objeciones a la declaración de inconstitucionalidad del régimen especial de reconocimiento de las universidades católicas
Authors: Polo Sabau José Ramón 
Published: April 2016

ResumenEn este trabajo se estudia el contenido de los numerosos votos particularesformulados a la sentencia del Tribunal Constitucional que, en 2013, decretó la invalidez de régimen especial de reconocimiento concedido a las universidades católicas por la Ley Orgánica de Universidades de 2001. Se realiza un análisis crítico de la perspectiva globalmente adoptada en esos votos y, especialmente, de algunas de las premisas que en ellos se adoptan, como es el caso de la llamadaconcepción proporcional de la igualdad religiosa, tradicionalmente asumida por un sector de la doctrina científica a partir de lo estipulado en el art. 16.3 CE y ahora también aceptada generalizadamente en el seno de estas opiniones disidentes.AbstractThis paper deals with the study of the numerous dissenting opinions present in the decision of the Spanish Constitutional Court that in 2013 invalidatedthe special legal status granted to the catholic universities in Spain’s Law bythe 2001 Universities Act. Extensive consideration is here give to the meaningof the main conceptions common to those dissenting opinions, and particularlyto the notion of the so called «proportional equality», traditionally developed by certain scholars with the aim to justify the different legal treatment given in Spain’s Law to the different denominations and now also present in most of those above mentioned dissenting opinions.