bluuebunny/crossref_metadata_2025_split huggingface dataset:
Leadership for the Sustainability Transition
Authors: Throop William , Mayberry Matt 
Published: June 2017

AbstractSociety is looking to business to help solve our most complex environmental and social challenges as we transition to a more sustainable economic model. However, without a fundamental shift in the dominant virtues that have influenced business decision making for the past 150 years to a new set of dominant virtues that better fit today's environment, it will be more natural for companies to resist the necessary changes than to find the opportunities within them. We use the term “virtues” quite broadly to describe dispositions to think, feel and act in skillful ways that promote the aims of a practice. Addressing this deeper level of cultural change is essential to cultivating new instinctive behavior in business decision making. In this article, we describe five clusters of virtues that facilitate effective response to the transition challenges—adaptive, collaborative, frugality, humility, and systems virtues. To illustrate the application of these virtues, we present a detailed case study of Green Mountain Power, a Vermont electric utility that has embraced the shift to renewable energy and smart‐grid technology, and is creating an innovative business model that is disrupting the industry. After distilling key findings from the case, we outline an approach to leadership development that can help accelerate the infusion of transitional virtues across an organization.
The journey between brain and gut: A systematic review of psychological mechanisms of treatment effect in irritable bowel syndrome
Authors: Windgassen Sula , Moss‐Morris Rona , Chilcot Joseph , Sibelli Alice , Goldsmith Kimberley , Chalder Trudie 
Published: June 2017

PurposeIrritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder characterized by abdominal pain and altered bowel habits. It is estimated to affect 10–22% of the UK population. The use of psychological interventions in IBS is increasingly empirically supported, but little is known about the mechanism of psychological treatment approaches. The present systematic review aimed to investigate the mechanisms of psychological treatment approaches applied to IBS.MethodsThe systematic review included studies conducting mediation analysis in the context of psychological interventions for IBS, focusing on the outcomes of symptom severity and/or quality of life (QoL).ResultsNine studies in total were included in the review. Eight of the studies assessed mediation in the context of cognitive behavioural‐based interventions, and one study assessed mediation in a mindfulness‐based stress reduction intervention. Results indicate that change in illness‐specific cognitions is a key process by which psychological treatments may have an effect on the outcomes of symptom severity and QoL. Furthermore, results suggest that whilst GI‐specific anxiety may also be a key mechanism of treatment effect, it would appear that general or state anxiety is not. Although less commonly included in mediation analysis, illness‐specific behaviours may also have a mediating role.ConclusionsA mediational model amalgamating the results of studies is proposed to illustrate the findings of the review. The model depicts the process by which psychotherapy changes illness‐specific cognitions, behaviours, and anxiety to achieve reduction in symptom severity.
Statement of contributionWhat is already known on this subject? Cognitive behavioural therapy (CBT) is the predominant psychological treatment for irritable bowel syndrome (IBS), although there is some research supporting other treatments such as mindfulness and hypnotherapy. Mediation analysis in the context of psychological treatments for IBS has just begun to explore possible mechanisms of treatment effect especially within CBT studies. Some studies include anxiety in a basic mediation analysis, whilst others include cognitions with inconsistent results for each.

What does this study add?

Reviews mediators included in mediation analysis and the methods used for mediation analysis

Proposes a mediation model informed by the results of the review for future studies to investigate

Provides clinical implications for the targeting of cognitions and behaviours rather than general anxiety
Chemokine (CC motif) ligand 18 upregulates Slug expression to promote stem‐cell like features by activating the mammalian target of rapamycin pathway in oral squamous cell carcinoma
Authors: Wang Hongfei , Liang Xueyi , Li Mianxiang , Tao Xiaoan , Tai Shanshan , Fan Zhaona , Wang Zhi , Cheng Bin , Xia Juan 
Published: June 2017

Chemokine (CC motif) ligand 18 (CCL18) is involved in remodeling of the tumor microenvironment and plays critical roles in oncogenesis, invasiveness, and metastasis. We previously investigated the overexpression of CCL18 in primary oral squamous cell carcinoma (OSCC) tissues and its association with advanced clinical stage in OSCC patients. However, the underlying mechanisms of this CCL18‐derived activity remains unidentified. This study showed exogenous CCL18 increased cell migration and invasion and induced cell epithelial–mesenchymal transition (EMT), and that E‐cadherin, an epithelial marker, decreased and N‐cadherin, a mesenchymal marker, increased, compared to negative control in OSCC cells. Furthermore, we detected that CCL18 induced the acquisition of cancer stem(‐like) cell characteristics in oral cancer cells, but also found a significantly positive correlation between the expression of CCL18 and Bmi‐1 (P < 0.001) in OSCC surgical specimens by immunohistochemistry analysis. The expression of octamer‐binding transcription factor 4 and Bmi‐1 were significantly upregulated, and proportions of aldehyde dehydrogenasehigh+ cells and CD133+ cells were markedly increased in CCL18‐treated cells compared to untreated cells. Sphere formation ability was observably enhanced when cells were continually exposed to high levels of CCL18. Moreover, CCL18 upregulated Slug expression by stimulating the mammalian target of rapamycin (mTOR) signaling pathway in OSCC cell lines. Inhibition of the mTOR pathway by INK128, or Slug knockdown by RNA interference, reversed CCL18‐induced EMT and the stemness response at both molecular and functional levels. In conclusion, our data suggested that CCL18 upregulated Slug expression to promote EMT and stem cell‐like features by activating the mTOR pathway in oral cancer. These findings provide new potential targets for the early diagnosis and treatment of OSCC.
Optimizing the combination insulin bolus split for a high‐fat, high‐protein meal in children and adolescents using insulin pump therapy
Authors: Lopez P. E. , Smart C. E. , McElduff P. , Foskett D. C. , Price D. A. , Paterson M. A. , King B. R. 
Published: June 2017

AbstractAimsTo determine the optimum combination bolus split to maintain postprandial glycaemia with a high‐fat and high‐protein meal in young people with Type 1 diabetes.MethodsA total of 19 young people (mean age 12.9 ± 6.7 years) participated in a randomized, repeated‐measures trial comparing postprandial glycaemic control across six study conditions after a high‐fat and high‐protein meal. A standard bolus and five different combination boluses were delivered over 2 h in the following splits: 70/30 = 70% standard /30% extended bolus; 60/40=60% standard/40% extended bolus; 50/50=50% standard/50% extended bolus; 40/60=40% standard/60% extended bolus; and 30/70=30% standard/70% extended bolus. Insulin dose was determined using the participant's optimized insulin:carbohydrate ratio. Continuous glucose monitoring was used to assess glucose excursions for 6 h after the test meal.ResultsStandard bolus and combination boluses 70/30 and 60/40 controlled the glucose excursion up to 120 min. From 240 to 300 min after the meal, the glucose area under the curve was significantly lower for combination bolus 30/70 compared with standard bolus (P=0.004).ConclusionsHigh‐fat and high‐protein meals require a ≥60% insulin:carbohydrate ratio as a standard bolus to control the initial postprandial rise. Additional insulin at an insulin:carbohydrate ratio of up to 70% is needed in the extended bolus for a high fat and protein meal to prevent delayed hyperglycaemia.
Once‐weekly administration of a long‐acting fibroblast growth factor 21 analogue modulates lipids, bone turnover markers, blood pressure and body weight differently in obese people with hypertriglyceridaemia and in non‐human primates
Authors: Kim Albert M. , Somayaji Veena R. , Dong Jennifer Q. , Rolph Timothy P. , Weng Yan , Chabot Jeffrey R. , Gropp Kathryn E. , Talukdar Saswata , Calle Roberto A. 
Published: June 2017

AimsTo assess the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐05231023, a long‐acting fibroblast growth factor 21 (FGF21) analogue, in obese people with hypertriglyceridaemia on atorvastatin, with or without type 2 diabetes.MethodsParticipants received PF‐05231023 or placebo intravenously once weekly for 4 weeks. Safety (12‐lead ECGs, vital signs, adverse events [AEs], laboratory tests) and longitudinal weight assessments were performed. Blood samples were collected for pharmacokinetic and pharmacodynamic analyses. Cardiovascular safety studies were also conducted in telemetered rats and monkeys. Blood pressure (BP; mean, systolic and diastolic) and ECGs were monitored.ResultsA total of 107 people were randomized. PF‐05231023 significantly decreased mean placebo‐adjusted fasting triglycerides (day 25, 33%‐43%) and increased HDL cholesterol (day 25, 15.7%‐28.6%) and adiponectin (day 25, 1574 to 3272 ng/mL) across all doses, without significant changes in body weight (day 25, −0.45% to −1.21%). Modest decreases from baseline were observed for N‐terminal propeptides of type 1 collagen (P1NP) on day 25, although C‐telopeptide cross‐linking of type 1 collagen (CTX‐1) increased minimally. Systolic, diastolic BP, and pulse rate increased in a dose‐ and time‐related manner. There were 5 serious AEs (one treatment‐related) and no deaths. Three participants discontinued because of AEs. The majority of AEs were gastrointestinal. PF‐05231023 increased BP and heart rate in rats, but not in monkeys.ConclusionsOnce‐weekly PF‐05231023 lowered triglycerides markedly in the absence of weight loss, with modest changes in markers of bone homeostasis. This is the first report showing increases in BP and pulse rate in humans and rats after pharmacological administration of a long‐acting FGF21 molecule.
Bone cement cardiac and pulmonary embolism
Authors: Cianciulli Tomás F. , Mc Loughlin Diego E. , Morita Luis A. , Saccheri María C. , Lax Jorge A. 
Published: June 2017

This case describes a complication of bone cement use. A 65‐year‐old male patient with back spine trauma caused by a fall, underwent a percutaneous vertebroplasty. Five years later, he consulted for palpitations, and the electrocardiogram showed supraventricular arrhythmia. A transthoracic two‐dimensional echocardiography showed a hyperechogenic linear structure of 7 cm length, running from the lateral wall of the right ventricle to the right atrium through the tricuspid valve. This foreign body, which was suspicious for bone cement embolism, appeared rigid and was attached at the lateral wall of the right ventricle, with its proximal end free in the right atrium. The tip of the cement embolus was inside the myocardium of the lateral wall of the right ventricle, with risk of cardiac perforation. A fluoroscopy was performed, which confirmed the presence of cement within the right heart, with great mobility in each cardiac cycle. Chest computed tomography (CT) and multidetector CT three‐dimensional reconstruction confirmed the presence of cement within the right heart. Chest CT showed two pulmonary embolisms, one in the right upper lobe and one in the left lower pulmonary lobe. This case emphasizes the risk of late clinical manifestations of cardiac and pulmonary embolism of methylmethacrylate after percutaneous vertebroplasty, suggesting that the risk of such embolism might be underestimated. We propose routine chest radiography, two‐dimensional echocardiography, and chest CT after every percutaneous vertebroplasty, to detect asymptomatic cardiac and pulmonary embolism and thereby prevent serious delayed cardiopulmonary failures.
Contextualizing Attitudes Toward Pronunciation: Foreign Language Learners in the United States
Authors: Huensch Amanda , Thompson Amy S. 
Published: June 2017

AbstractWhile previous work has shown a relationship between pronunciation attitudes and pronunciation performance, the connection between language learning motivation and pronunciation attitudes has been underexplored. This study investigated the relationship between 195 foreign language learners’ attitudes toward pronunciation, the foreign languages studied, extramural language activity, and motivation. With an online three‐part survey, information was collected about their language learning backgrounds; their ideal, ought‐to, and anti‐ought‐to selves (Dörnyei, 2009; Thompson & Vásquez, 2015); and their attitudes toward pronunciation (Elliott, 1995a). The results from an exploratory factor analysis on the pronunciation items indicated a three‐factor solution: lack of native speaker bias, importance of improving pronunciation, and importance of communication/skills other than pronunciation. There were significant group differences for class level and extramural language activity regarding learners’ perceived importance of improving pronunciation: Learners in upper‐level classes as well as learners who participated in extramural language activity placed a higher importance on improving pronunciation. The results also indicated positive relationships between positive attitudes toward pronunciation and the ideal self, and between the desire to improve pronunciation and the anti‐ought‐to self. The findings have implications for the selection of materials and instructional approaches.
Wide local excision vs. Mohs Tübingen technique in the treatment of dermatofibrosarcoma protuberans: a two‐centre retrospective study and literature review
Authors: Veronese F. , Boggio P. , Tiberio R. , Gattoni M. , Fava P. , Caliendo V. , Colombo E. , Savoia P. 
Published: June 2017

AbstractBackgroundDermatofibrosarcoma protuberans (DFSP) is a rare, low‐grade mesenchymal skin tumour, characterized by slow infiltrative growth and common local recurrence, with infrequent distant metastases.ObjectiveThe aim of this study is to better clarify clinicopathological characteristics of this tumour and to evaluate the cure rates of Mohs Tübingen technique (MTT) and wide local excision (WLE). Eventually, we perform a literature review to compare our experience with published data.MethodsA retrospective review was conducted on 135 patients diagnosed, treated and followed up between 1997 and 2014 at two different institutions. Sixty‐two patients underwent to WLE and 73 to MTT. The primary end‐points were the following: percentage of recurrences, time to progression and recurrence annual risk rate. Then, the PubMed database was searched for DFSP case series treated with standard surgical resection (SSR), WLE, Mohs’ micrographic surgery (MMS) and MTT. The annual risk rate of recurrence calculated and reported for the four separate procedures was pooled to compare them.ResultsFive of the 62 patients with WLE (8.1%) experienced recurrences after a mean follow‐up of 4.7 years; the percentage of recurred patients 9 years after MTT was 5.5%, and the annual recurrence risk rate of 0.6%. Pooling these data with those from literature, the recurrence rate varies from 26% to 60% for SSR, from 0% and 41% for WLE, from 0% and 8.3% for MMS and from 0% to 5.5% for MTT. The lowest annual recurrence risk rate was found for MTT.ConclusionSignificantly lower recurrence rates were recorded in patients treated with classic or Tübingen Mohs’ technique. To the best of our knowledge, our case series is the widest treated with MTT ever described in the literature; these data may be useful to guide clinicians in the choice of the gold standard treatment for Dermatofibrosarcoma protuberans.
Determination of Mars crater geometric data: Insights from high‐resolution digital elevation models
Authors: Mouginis‐Mark Peter J. , Boyce Joseph , Sharpton Virgil L. , Garbeil Harold 
Published: June 2017

AbstractWe review the methods and data sets used to determine morphometric parameters related to the depth (e.g., rim height and cavity depth) and diameter of Martian craters over the past ~45 yr, and discuss the limitations of shadow length measurements, photoclinometry, Earth‐based radar, and laser altimetry. We demonstrate that substantial errors are introduced into crater depth and diameter measurements that are inherent in the use of 128th‐degree gridded Mars Orbiter Laser Altimeter (MOLA) topography. We also show that even the use of the raw MOLA Precision Engineering Data Record (PEDR) data can introduce errors in the measurement of craters a few kilometers in diameter. These errors are related to the longitudinal spacing of the MOLA profiles, the along‐track spacing of the individual laser shots, and the MOLA spot size. Stereophotogrammetry provides an intrinsically more accurate method for measuring depth and diameter of craters on Mars when applied to high‐resolution image pairs. Here, we use 20 stereo Context Camera (CTX) image pairs to create digital elevation models (DEMs) for 25 craters in the diameter range 1.5–25.6 km and cover the latitude range of 25° S to 42° N. These DEMs have a spatial scale of ~24 m per pixel. Six additional craters, 1.5–3.1 km in diameter, were studied using publically available DEMs produced from High‐Resolution Imaging Science Experiment (HiRISE) image pairs. Depth/diameter and rim height were determined for each crater, as well as the azimuthal variation of crater rim height in 1‐degree increments. These data indicate that morphologically fresh Martian craters at these diameters are significantly deeper for a given size than previously reported using Viking and MOLA data, most likely due to the improvement in spatial resolution provided by the CTX and HiRISE data.
Aromatherapy massage versus reflexology on female elderly with acute coronary syndrome
Authors: Bahrami Tahereh , Rejeh Nahid , Heravi‐Karimooi Majideh , Vaismoradi Mojtaba , Tadrisi Seyed Davood , Sieloff Christina L 
Published: June 2017

SUMMARYBackgroundFatigue and abnormalities in cardiovascular parameters are recognized as major problems for patients with acute coronary syndrome. Non‐pharmacological nursing interventions are useful for controlling this fatigue and reducing patients' suffering during hospitalization.AimThe present study compared the effects of aromatherapy massage and reflexology on fatigue and cardiovascular parameters in older female patients with acute coronary syndrome.DesignThis study was a randomized clinical trial.MethodsThe study was conducted with 135 older female patients with acute coronary syndrome who were hospitalized in a cardiac care unit in 2014. They were invited to participate in the study and then were randomly divided into three groups: ‘aromatherapy massage’, ‘reflexology’ and ‘control’. The fatigue severity and cardiovascular parameters were assessed using the Rhoten fatigue scale and a checklist. Measurements in the groups were performed before and immediately after the intervention. Data analysis was performed using descriptive and analytical statistics via theSPSSsoftware.ResultsAromatherapy massage significantly decreased fatigue, systolic blood pressure, mean arterial pressure andO2saturation more than the reflexology intervention. However, reflexology reduced patients' heart rates more than an aromatherapy massage (P < 0·05). Moreover, no significant changes were observed in patients' diastolic blood pressures when compared to the control group (P = 0·37).ConclusionsImplementation of both aromatherapy massage and reflexology has positive effects on the fatigue and cardiovascular parameters of patients with acute coronary syndrome. However, aromatherapy massage can be more beneficial to use as a supportive approach in coronary diseases.Relevance to clinical practiceThe need for reducing fatigue in acute coronary syndrome (ACS) patients in a cardiac care unit is evident. The implementation of aromatherapy massage and reflexology had positive effects on patients' fatigue as related to both physical and mental health.
Draft Genome Sequences of Listeria monocytogenes, Isolated from Fresh Leaf Vegetables in Owerri City, Nigeria
Authors: Nwaiwu Ogueri , Moura Alexandra , Thouvenot Pierre , Rees Catherine , Leclercq Alexandre , Lecuit Marc 
Published: June 2017

ABSTRACT

Here, we report the draft genome sequences of three
Listeria monocytogenes
isolates from fresh leaves collected in Nigeria, belonging to sequence types ST5 and ST155 (sublineages SL5 and SL155, respectively).
First Insights into the Genome of the Cr(VI)-Reducing Bacterium Clostridium chromiireducens DSM 23318
Authors: Poehlein Anja , Höche Nils , Mehr Alexander , Daniel Rolf 
Published: June 2017

ABSTRACT

Clostridium chromiireducens
is an obligate, anaerobic, Gram-positive, rod-shaped, and spore-forming bacterium that is able to reduce Cr(VI). The draft genome consists of one chromosome (5,448 Mb) and contains 4,773 predicted protein-encoding genes.
Complete Genome Assembly of Pantoea stewartii subsp.
stewartii
DC283, a Corn Pathogen
Authors: Duong Duy An , Stevens Ann M. , Jensen Roderick V. 
Published: June 2017

ABSTRACT

The phytopathogen
Pantoea stewartii
subsp.
stewartii
DC283 causes Stewart’s wilt disease in corn after transmission from the corn flea beetle insect vector. Here, we report that the complete annotated genome of
P. stewartii
DC283 has been fully assembled into one circular chromosome, 10 circular plasmids, and one linear phage.
Draft Genome Sequence of the Clover (Trifolium repens L.) Root Endophyte
Paraburkholderia
sp. Strain A27
Authors: Laugraud Aurelie , Young Sandra , Gerard Emily , O’Callaghan Maureen , Wakelin Steven 
Published: June 2017

ABSTRACT

Paraburkholderia
sp. strain A27, isolated from the root material of white clover, has plant growth-promoting activity on a range of agriculturally important plants. The draft genome of this bacterium is 7,393,089 bp and harbors a range of genes putatively involved in host colonization.
Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine
Authors: Hurwitz Julia L. , Tuomanen Elaine 
Published: June 2017

ABSTRACT
In modern-day vaccine design, a good pneumococcal capsular polysaccharide vaccine is measured by its ability to induce opsonic antibodies. These antibodies label bacteria for phagocytosis by neutrophils and thereby overcome the capsule’s barrier function. Doyle and Pirofski have raised a serious challenge to the current paradigm by describing anti-capsular antibodies that are highly protective but nonopsonic [C.R. Doyle and L. Pirofski, mBio 7(1):e02260-15, 2016, doi:10.1128/mBio.02260-15]. In fact, some functions are not related to neutrophils or phagocytosis at all. An increased awareness of these activities is critical not only for accurate comparisons of vaccine candidates but also for improvements in vaccination outcomes in settings of neutropenia. When vaccine developers select a single gatekeeper assay (e.g., an opsonophagocytic assay for bacteria or a neutralization assay for viruses), promising vaccine candidates may be missed. Doyle and Pirofski stress that multiple functions, not just one, should be investigated to enhance discovery of antibody mechanisms and to best assess vaccine-induced correlates of immune protection.