bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is it my cancer or am i just getting older?: Impact of cancer on age‐related health conditions of older cancer survivors
Authors: Leach Corinne R. , Bellizzi Keith M. , Hurria Arti , Reeve Bryce B. 
Published: May 2016

BACKGROUNDThe extent to which cancer exacerbates or creates new health conditions is a long‐standing, unanswered question. The current prospective study examined the short‐term impact of cancer on the functioning, development of, and worsening of age‐related health conditions among older adults who develop cancer compared with age‐matched controls.METHODSSurveillance, Epidemiology, and End Results registry data were linked with Medicare Health Outcomes Survey (MHOS) data. A total of 921 eligible cases were Medicare beneficiaries with diagnosis of breast, colorectal, lung, or prostate cancer made between their baseline and follow‐up MHOS. Using propensity score matching, 4605 controls without cancer were matched from the MHOS. Analysis of covariance and logistic regression were used to examine changes in physical functioning, activities of daily living, age‐related conditions, and exacerbation of preexisting conditions for cases compared with controls.RESULTSCancer groups demonstrated greater declines in activities of daily living and physical function compared with controls (mean, ‐1.53 [standard error, 0.14]), with the greatest change noted for patients with lung cancer (mean, ‐6.72 [standard error, 0.94]). Having a cancer diagnosis increased the risk of depression but did not increase the odds of developing arthritis in the hand and/or hip, urinary incontinence (except for prostate cancer), or vision and/or hearing problems. Having a cancer diagnosis also did not exacerbate the severity of arthritis or foot neuropathy.CONCLUSIONSThe findings of the current study suggest that cancer is a stronger driver for declines in physical functioning and an increased risk of depression in older adults. Interventions are needed to decrease these risks. Clinicians need to prepare patients and families for changes in functioning levels and interventions that limit the declines for older patients with cancer are needed. Cancer 2016;122:1946–53. © 2016 American Cancer Society.
Morphologists overestimate the nuclear‐to‐cytoplasmic ratio
Authors: Zhang Mingjuan L. , Guo Alan X. , VandenBussche Christopher J. 
Published: May 2016

BACKGROUNDThe Paris System for Reporting Urinary Cytology (TPS) has defined nuclear‐to‐cytoplasmic (N:C) ratio cutoff values for several of its risk‐stratified diagnostic categories. However, because pathologists are not trained to recognize strict N:C ratio cutoff values, a previously designed survey was used to determine whether pathologists could accurately identify N:C ratios according to TPS standards.METHODSParticipants were instructed to estimate the N:C ratio of ideal (line drawing) and real (cell photograph) images presented via an online survey. Actual N:C ratios ranged from 0.3 to 0.8, and 3 answer choices were available: < 0.5, ≥ 0.5 and <0.7, and ≥0.7. The resulting data were analyzed to determine the accuracy and performance of the subgroups.RESULTSA total of 137 individuals completed the survey. Approximately 24.1% were cytopathologists, 18.2% were pathologists without formal cytopathology training, 18.2% were cytotechnologists, 24.1% were pathology residents, and 15.3% were nonmorphologists. Overall, 70.0%, 67.6%, and 93.3% of responses, respectively, were correct for images with an N:C ratio of < 0.5, ≥0.5 and < 0.7, and ≥0.7. For images with an actual N:C ratio < 0.5 and ≥0.5 and < 0.7, 30.0% and 25.0% of responses, respectively, overestimated the N:C ratio. Furthermore, for images with an N:C ratio of 0.4 and 0.6, > 40.0% of responses overestimated the N:C ratio. As a whole, morphologists were significantly more accurate than nonmorphologists (P = .030).CONCLUSIONSMorphologists tended to overestimate the N:C ratio, particularly at ratios close to TPS‐recommended cutoff values. Additional training regarding N:C ratio estimation may help pathologists to adapt to this new system. Cancer Cytopathol 2016;124:669–77. © 2016 American Cancer Society.
Ion Intercalation Induced Capacitance Improvement for Graphene‐Based Supercapacitor Electrodes
Authors: Liu Tianyu , Zhu Cheng , Kou Tianyi , Worsley Marcus A. , Qian Fang , Condes Cecilia , Duoss Eric B. , Spadaccini Christopher M. , Li Yat 
Published: May 2016

AbstractHere we demonstrate a facile electrochemical method that can substantially improve the capacitance of graphene‐based electrodes while still retaining their excellent rate capability. This method involves two ion‐intercalation steps (lithium‐ion intercalation and perchlorate‐ion intercalation), followed by hydrolysis of perchlorate ion intercalation compounds. Lithium ion intercalation mainly leads to surface exfoliation, whilst the hydrolysis of perchlorate ion intercalation compounds functionalizes the graphene surface with oxygen moieties. Electrochemically treated graphitic paper electrode shows 1000 times enhancement in areal capacitance. Without the need of post‐treatment annealing, the treated graphitic paper maintains an outstanding rate capability of 84 % (0.5 mA cm−2 to 5 mA cm−2). The same strategy can also be extended to boost the gravimetric capacitance of lightweight 3D printed graphene aerogels. The treated graphene aerogel achieved an outstanding gravimetric capacitance of 101.7 F g−1 (10 A g−1) with an excellent rate capability of 81.6 % (0.5 A g−1 to 10 A g−1).
Microporous Lanthanide Metal–Organic Frameworks with Multiple 1D Channels: Tunable Colors, White‐Light Emission, and Luminescent Sensing for Iron(II) and Iron(III)
Authors: Zhou Zhong‐Yuan , Han Yun‐Hu , Xing Xiu‐Shuang , Du Shao‐Wu 
Published: May 2016

AbstractA new series of isostructural lanthanide‐based metal–organic frameworks, [H3O][HN(CH3)3]2[Ln3L6] (Ln=Gd (1), Eu (2), and Tb (3); H2L=1,3‐benzenedicarboxylic acid), was prepared under solvothermal conditions. Single‐crystal XRD studies reveal that these compounds are 3D microporous frameworks with 1D channels distributed in four different directions. The 1D channels contain protonated water molecules and trimethylammonium cations, which can be partially exchanged with different metal ions. Notably, these compounds do not contain any coordinated solvent molecules because the coordination sphere of the Ln3+ ion is fully occupied by chelating and bridging carboxylate oxygen atoms. Tunable colors and white‐light emission can be achieved by encapsulating different molar ratios of Eu3+ and Tb3+ ions in the Gd framework through cation exchange. In addition, the Eu framework can act as a sensitive and selective luminescence sensor for both Fe2+ and Fe3+.
Activation‐dependent cell death of human monocytes is a novel mechanism of fine‐tuning inflammation and autoimmunity
Authors: Däbritz Jan , Weinhage Toni , Varga Georg , Wirth Timo , Ehrchen Jan M. , Barczyk‐Kahlert Katarzyna , Roth Johannes , Schwarz Tobias , Foell Dirk 
Published: May 2016

In patients with juvenile idiopathic arthritis (JIA), increased release of IFN‐γ and GM‐CSF in cells infiltrating synovial tissue can be a potent driver of monocyte activation. Given the fundamental role of monocyte activation in remodeling the early phases of inflammatory responses, here we analyze the GM‐CSF/IFN‐γ induced activity of human monocytes in such a situation in vitro and in vivo. Monocytes from healthy donors were isolated and stimulated with GM‐CSF ± IFN‐γ. Monocyte activation and death were analyzed by flow cytometry, immunofluorescence microscopy, ELISA, and qPCR. T‐cell GM‐CSF/IFN‐γ expression and monocyte function were determined in synovial fluid and peripheral blood from 15 patients with active JIA and 21 healthy controls. Simultaneous treatment with GM‐CSF and IFN‐γ induces cell death of monocytes. This cell death is partly cathepsin B‐associated and has morphological characteristics of necrosis. Monocytes responding to costimulation with strong proinflammatory activities are consequently eliminated. Monocytes surviving this form of hyperactivation retain normal cytokine production. Cathepsin B activity is increased in monocytes isolated from synovial fluid from patients with active arthritis. Our data suggest GM‐CSF/IFN‐γ induced cell death of monocytes as a novel mechanism to eliminate overactivated monocytes, thereby potentially balancing inflammation and autoimmunity in JIA.
3D Nano‐structure L‐cysteine/AuNPs/Bi2O3 Modified Glass Carbon Electrode as Chemical Sensor for Highly Sensitive and Selective Detection Cu (II)
Authors: Zhou Enhong , Wu Ju , Li Linna , Yang Mei , Jin Juncheng , Fu Xucheng , Chang Wengui , Xie Chenggen 
Published: May 2016

AbstractIt was first time using the l‐cysteine self‐assembled on the surface of gold nanoparticles and Bi2O3 nano‐structured materials modified GCE composed l‐cysteine/AuNPs/Bi2O3/GCE sensor. The sensor possessed three‐dimensional nanostructure and exhibited a higher ratio of activity sites, large active surface, fast electron transfer rate, excellent catalytic, sensing characteristics and larger affinity to Cu (II). The sensor was determined to have an excellent sensitivity and selectivity for the detection of Cu (II). The characterization of sensor as well as the optimization of the analytical procedure was reported. The optimized conditions parameters allowed the detection of Cu (II) concentration following short analysis time, a detection limit of 5×10−11 M at 80 s of preconcentration time was obtained using the as‐prepared sensor, and also show excellent stability and good repeatability, and, thus, could be used for detection of Cu (II) in environment.
Ruthenium Hexacyanoferrate (III) Modified Glassy Carbon Electrode for Determination of Captopril
Authors: Dias I. A. R. B. , Costa W. M. , Cervini P. , Cavalheiro E. T. G. , Marques A. L. B. 
Published: May 2016

AbstractA glassy carbon electrode modified with a ruthenium (III) hexacyanoferrate film was investigated for the determination of captopril in pharmaceutical formulations. The RuOHCF film was deposited on the surface of the electrode after applying 50 successive cycles and subsequent stabilization in a mixture of NaNO3 0.50 mol L−1+HCl 0.050 mol L−1 used as supporting electrolyte. The main processes responsible for the redox electrode response are attributed to the system RuII/RuIII/RuIV, and appeared at −0.080, 0.86 and 1.01 V (vs. SCE). The redox process at −0.080 V was selected for the determination of captopril in the present study, once it provided higher sensibility and occurs in a lower potential than the other ones which can prevent interferences. The experimental parameters used in the determination of the analyte, using differential pulse voltammetry were optimized: pulse amplitude: 50 mV, scan rate: 5 mV s−1 and potential window: −0.5 to 0.2 V (vs. SCE). The analytical application of the sensor in real samples demonstrated a linear range between 0.060 and 0.80 µmol L−1 (r=0.998) with a detection limit of 0.047 µmol L−1. A mechanism based on co‐precipitation of captopril and the Ru (III) complex in the film is presented once the signal of the RuII/III redox couple decreases with increasing the analyte concentration. Recoveries of 99 to 100 % were achieved in pharmaceutical samples and the proposed procedure agreed with the HPLC official method within 95 % confidence level, according to the t‐Student test.
Automated segmentation of the human hippocampus along its longitudinal axis
Authors: Lerma‐Usabiaga Garikoitz , Iglesias Juan Eugenio , Insausti Ricardo , Greve Douglas N. , Paz‐Alonso Pedro M. 
Published: May 2016

AbstractThe human hippocampal formation is a crucial brain structure for memory and cognitive function that is closely related to other subcortical and cortical brain regions. Recent neuroimaging studies have revealed differences along the hippocampal longitudinal axis in terms of structure, connectivity, and function, stressing the importance of improving the reliability of the available segmentation methods that are typically used to divide the hippocampus into its anterior and posterior parts. However, current segmentation conventions present two main sources of variability related to manual operations intended to correct in‐scanner head position across subjects and the selection of dividing planes along the longitudinal axis. Here, our aim was twofold: (1) to characterize inter‐ and intra‐rater variability associated with these manual operations and compare manual (landmark based) and automatic (percentage based) hippocampal anterior–posterior segmentation procedures; and (2) to propose and test automated rotation methods based on approximating the hippocampal longitudinal axis to a straight line (estimated with principal component analysis, PCA) or a quadratic Bézier curve (fitted with numerical methods); as well as an automated anterior–posterior hippocampal segmentation procedure based on the percentage‐based method. Our results reveal that automated rotation and segmentation procedures, used in combination or independently, minimize inconsistencies generated by the accumulation of manual operations while providing higher statistical power to detect well‐known effects. A Matlab‐based implementation of these procedures is made publicly available to the research community. Hum Brain Mapp 37:3353–3367, 2016. © 2016 Wiley Periodicals, Inc.
Training your brain to be more creative: brain functional and structural changes induced by divergent thinking training
Authors: Sun Jiangzhou , Chen Qunlin , Zhang Qinglin , Li Yadan , Li Haijiang , Wei Dongtao , Yang Wenjing , Qiu Jiang 
Published: May 2016

AbstractCreativity is commonly defined as the ability to produce something both novel and useful. Stimulating creativity has great significance for both individual success and social improvement. Although increasing creative capacity has been confirmed to be possible and effective at the behavioral level, few longitudinal studies have examined the extent to which the brain function and structure underlying creativity are plastic. A cognitive stimulation (20 sessions) method was used in the present study to train subjects and to explore the neuroplasticity induced by training. The behavioral results revealed that both the originality and the fluency of divergent thinking were significantly improved by training. Furthermore, functional changes induced by training were observed in the dorsal anterior cingulate cortex (dACC), dorsal lateral prefrontal cortex (DLPFC), and posterior brain regions. Moreover, the gray matter volume (GMV) was significantly increased in the dACC after divergent thinking training. These results suggest that the enhancement of creativity may rely not only on the posterior brain regions that are related to the fundamental cognitive processes of creativity (e.g., semantic processing, generating novel associations), but also on areas that are involved in top‐down cognitive control, such as the dACC and DLPFC. Hum Brain Mapp 37:3375–3387, 2016. © 2016 Wiley Periodicals, Inc.
Resection and microvascular reconstruction of bisphosphonate‐related osteonecrosis of the jaw: The role of microvascular reconstruction
Authors: Neto Tiago , Horta Ricardo , Balhau Rui , Coelho Lígia , Silva Pedro , Correia‐Sá Inês , Silva Álvaro 
Published: May 2016

AbstractBackgroundCurrent treatment guidelines caution against osseous reconstruction using free flap tissue to treat bisphosphonate‐related osteonecrosis of the jaw (BRONJ). The primary rationale for this stance is the theoretical risk of nonunion and recurrence of disease within the reconstruction. Emerging evidence suggests that these theoretical risks may be overestimated. We performed a literature review of this procedure for the treatment of advanced BRONJ. We also present a new case report of resection and microvascular reconstruction in a 58‐year‐old man with stage III BRONJ.MethodsA MEDLINE search was performed to gather all reports of maxillary and mandibular reconstruction using free tissue flap transfer for BRONJ. Inclusion criteria were confirmed stage II or III BRONJ, free tissue transfer and reconstruction, and reported complications. Articles were excluded if they contained only local flap reconstruction, wound closure without reconstruction, or osteoradionecrosis. Outcomes from our case report were added to the analysis.ResultsWe identified 10 articles that met criteria. Adding our case, we identified 40 cases of free flap reconstruction. The rate of nonunion was 5% (2 of 40). Fistulas formed in 4 cases (10%). BRONJ recurred in 2 cases (5%).ConclusionComplication rates after free flap microvascular reconstruction in BRONJ seem acceptable. Nonunion is relatively rare and should not be the sole reason to recommend against free flap reconstruction. A randomized clinical trial would help clarify the role of this procedure in refractory BRONJ; however, we believe that segmental resection and microvascular reconstruction is a viable option in select cases of BRONJ. © 2016 Wiley Periodicals, Inc. Head Neck 38:1278–1285, 2016
Myocardin inhibits estrogen receptor alpha‐mediated proliferation of human breast cancer MCF‐7 cells via regulating MicroRNA expression
Authors: Xiang Yuan , Lu Da‐Lin , Li Jia‐Peng , Yu Cheng‐Xi , Zheng De‐Liang , Huang Xuan , Wang Zhen‐Yu , Hu Peng , Liao Xing‐Hua , Zhang Tong‐Cun 
Published: May 2016

AbstractMyocardin is frequently repressed during human malignant transformation, and restoration of myocardin expression in sarcoma cells contributes to the inhibition of malignant growth. However, its role in breast carcinoma has barely been addressed. Here, we reported that myocardin could inhibit the proliferation of MCF‐7 cells. Notably, we show that myocardin inhibited ERα‐mediated proliferation of breast cancer MCF‐7 via impairing ER‐dependent transcriptional activation, mainly through the inhibition of the activity of ERα. Importantly, the molecular mechanism for the inhibition of the ERα‐mediated proliferation is that myocardin inhibited the transcription and expression of ERα‐induced PCNA, Ki‐67, and E2F1 to impair ERα‐mediated proliferation of breast cancer MCF‐7. Interestingly, myocardin significantly enhanced the transcription and expression of miR‐885 depending on the CArG box in miR‐885 promoter, and miR‐885 targeted the 3′ untranslated regions (UTR) of E2F1 to silence the expression of E2F1. Thus, our data provided important and novel insights into how myocardin may deeply influence ERα‐mediated breast cancer proliferation. In conclusion, myocardin could be seen as a breast cancer tumor suppressor so that it will provide new ideas for the treatment of breast cancer. © 2016 IUBMB Life, 68(6):477–487, 2016
No effect of tumor‐infiltrating lymphocytes (TILs) on prognosis in patients with early triple‐negative breast cancer: Validation of recommendations by the International TILs Working Group 2014
Authors: Park Hyung Seok , Heo Ilyeong , Kim Jee Ye , Kim Sanghwa , Nam Sanggeun , Park Seho , Kim Seung Il 
Published: May 2016

PurposeThe aim of this study was to examine the International TILs Working Group 2014 (IWG) recommendations for evaluating the clinical utility of tumor‐infiltrating lymphocytes (TILs) in patients with early triple‐negative breast cancer (TNBC).MethodsRecords for 133 patients with early TNBC who underwent surgery between 2008 and 2010 were reviewed. A total of 121 of 133 formalin‐fixed, paraffin‐embedded tumor samples were available and reviewed following IWG recommendations.ResultsMost of the patients had node‐negative T1‐2 tumors and received adjuvant chemotherapy; T1‐2 tumors accounted for 117 of 121 cases. Sixty‐two percent (75/121) of all patients had >10% stromal TILs. Intratumoral TILs and lymphocyte‐predominant breast cancer (LPBC) were observed in 72% and 19% of the patients, respectively. However, there were no significant differences according to the presence of stromal TILs, intratumoral TILs, TILs at the invasive edge, or LPBC in terms of recurrence‐free and overall survival (all P > 0.05). A multivariate analysis adjusted for T and N stage, grade, and adjuvant chemotherapy revealed that no TILs parameters were associated with survival outcomes.ConclusionsTILs evaluations following the IWG recommendations may not be useful for predicting survival outcomes in patients with early TNBC. J. Surg. Oncol. 2016;114:17–21. © 2016 Wiley Periodicals, Inc.
Clinicopathologic and survival analysis of resected ampullary adenocarcinoma
Authors: Doepker Matthew P. , Thompson Zachary J. , Centeno Barbara A. , Kim Richard D. , Wong Joyce , Hodul Pamela J. 
Published: May 2016

IntroductionAmpullary adenocarcinoma (AAC) is a rare neoplasm. We sought to determine the clinicopathologic factors contributing to the overall survival (OS) and recurrence‐free (RFS) survival.MethodsPatients (pts) with resected AAC were identified from 1996 to 2015 and reviewed for clinicopathologic factors and correlated with outcome.ResultsWe identified and evaluated 106 pts diagnosed with AAC. The median age was 70.2 years (range 41–86) and 60 (56.6%) were male. Overall, 105 pts (99.1%) had a pancreaticoduodenectomy. An R0 resection was achieved in 101 (95%) pts. Median follow‐up was 19 months with a median OS of 49.3 months. Lymph node metastasis and poorly differentiated tumors adversely affected OS on multivariate analysis (MVA). Twenty patients (18.9%) developed recurrence. The median RFS was 27 months. RFS was adversely affected by lymph node count and metastasis, tumor differentiation, and histological subtype on MVA. Survival was not affected by the addition of adjuvant therapy. Retrieval of ≤12 lymph nodes and lymph node ratio ≥0.10 resulted in worse OS on Kaplan–Meier analysis.ConclusionsOur data show retrieval of ≤12 nodes, involvement of nodes with AAC, moderately or poorly differentiated tumors, and pancreaticobiliary subtype adversely affected survival, while the use of adjuvant therapy demonstrated no significant benefit. J. Surg. Oncol. 2016;114:170–175. © 2016 Wiley Periodicals, Inc.
Anastomotic recurrence of colon cancer: Genetic analysis challenges the widely held theories of cancerous cells’ intraluminal implantation and metachronous carcinogenesis
Authors: Costi Renato , Santi Caterina , Bottarelli Lorena , Azzoni Cinzia , Zarzavadjian Le Bian Alban , Riccó Matteo , Sarli Leopoldo , Silini Enrico Maria , Violi Vincenzo 
Published: May 2016

Background and ObjectivesAnastomotic recurrence (AR), whose etiopathogenesis is attributed to intraluminal implantation of cancerous cells or metachronous carcinogenesis, is a major issue for patients undergoing colon cancer (CC) resection. The objective of the study is to throw some light on AR etiopathogenesis and to identify risk factors of AR in selecting patients to undergo early endoscopy.MethodsAn analysis of clinical and histopathological parameters, including MSI and LOH of seven sites (Myc‐L, BAT26, BAT40, D5S346, D18S452, D18S64, D16S402) was performed in primary CC and AR of 18 patients. They were then compared to 36 controls not developing AR.ResultsA genetic instability was present in 16/18 patients, with distinct genetic patterns between primaries and ARs. LOH at 5q21 and/or 18p11.23 were found in both primary and AR in >50% of cases, but this rate was no different from control population. CEA resulted as associated with AR (P = 0.03), whereas N status presented a borderline result (P = 0.08).ConclusionsOur findings challenge present theories about AR development. No “genetic marker” has been found. CEA and, to a lesser extent, N status, appear associated with AR. Rectal washout is seemingly meaningless. Iterative resection should be recommended since a long survival may be expected. J. Surg. Oncol. 2016;114:228–236. © 2016 Wiley Periodicals, Inc.