bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term effectiveness and safety of long-acting growth hormone preparation in children with growth hormone deficiency
Authors: Kang Eungu , Chung Lindsey Yoojin , Rhie Young-Jun , Lee Kee-Hyoung , Nam Hyo-Kyoung 
Published: October 2024

Abstract

Objectives
To evaluate the long-term effectiveness of weekly vs. daily growth hormone (GH) administration in children with GH deficiency.

Methods
This study, part of the “LG Growth Study”, included a total of 996 children with GH deficiency (773 receiving daily GH and 193 receiving weekly GH). Anthropometric data were collected at baseline and every 12 months; clinical and laboratory data were collected at baseline and throughout the study.

Results
At baseline, the weekly GH group was older, shorter in mid-parental height (MPH), and had more pubertal boys compared to the daily GH group (age: 8.46 ± 3.44 vs. 7.46 ± 2.89 years, p<0.001; MPH: −0.88 ± 0.73 SD vs. −1.02 ± 0.84 SD, p=0.044; pubertal boys: 34.0 vs. 16.9 %, p=0.006). Height velocity and change in height SDS during the first 12 months were higher in the daily GH group (height velocity: 9.06 ± 1.72 vs. 8.67 ± 1.98 cm/year, p=0.028; height SDS change: 0.78 ± 0.39 vs. 0.61 ± 0.41, p<0.001). However, height SDS at 24 and 48 months were similar between groups. No significant differences in overall height velocity, annualized treatment continuation rate, and safety profile were observed over 48 months.

Conclusions
Weekly GH therapy appears to be an effective and safe alternative to daily GH treatment in children with GH deficiency over a 4-year period. Further research with larger sample sizes and longer follow-up is needed to confirm these findings and assess the extended safety and effectiveness of LAGH.
Imagined versus practiced professional identity development: a multimodal (inter)action analysis of a Chinese novice english teacher
Authors: Zhou Jing , Tennant Lewis , Matelau Tui 
Published: October 2024

Abstract
The journey from a novice to an established educator is fraught with challenges that significantly impact the development of a professional identity. This study examines the experiences of novice university English language teachers in China, focusing on Caroline, an early career teacher who navigates the challenge of navigating a high power culture and integrating into established teaching communities. Employing Multimodal (Inter)action Analysis (MIA), this research offers a nuanced examination of the interplay between Caroline’s imagined and practiced identities. The findings reveal the complexities of her identity formation, highlighting struggles with exclusion, resistance from senior colleagues, and the reconciliation of her aspirations with professional realities. The study advocates for a comprehensive approach to teacher training and support, emphasizing the need for emotional resilience, personal growth, and the integration of theory with practice. It suggests targeted mentorship, the creation of supportive ecosystems, and the adaptation of educational policies to better prepare novice educators for the multifaceted challenges of the teaching profession. This case study contributes to the global discourse on teacher identity formation, offering insights that can inform the development of more effective support structures for novice teachers, thus enhancing the quality of education.
Strategizing IoT Platforms for Enhanced Hygrothermal Monitoring and Control in Libraries: A Transition from Passive to Proactive Operations
Authors: Sharath G. V. Krishna 
Published: October 2024

Abstract
The management of book preservation, back volumes, and other publications within a library predominantly falls under the responsibility of library staff. The application of IoT technology in this context lacks a systematic approach to monitoring and controlling hygrothermal factors. Presently, IoT utilization is confined to a passive mode of monitoring, recording, and logging. This concise study aims to strategize and recommend the optimal utilization of IoT platforms, transitioning from a passive observational mode to a more proactive and autonomous operational mode. A qualitative methodology was employed to devise and execute the integration of IoT technology, focusing on communication through the LoRa platform and data sharing via the Wi-Fi network. Upon thorough examination of the integrated IoT platform, opportunities for implementation and enhancement become apparent. Through meticulous analysis and execution of the planned IoT platform with a scope of improvement by IIoT and battery-free sensors, a viable solution is identified, and a comprehensive evaluation of its attributes is performed.
Neptunium(V) N,N′-dicyanoguanidinate complexes with electroneutral N-donor ligands
Authors: Grigoriev Mikhail S. , Charushnikova Iraida A. , Fedoseev Alexander M. 
Published: October 2024

Abstract
Four new Np(V) dicyanoguanidinate complexes with neutral N-donor ligands were synthesized and structurally characterized: [(NpO2)(Bipy)(C(NH2)(NCN)2)(H2O)]·2H2O (1), [(NpO2)(Phen)(C(NH2)(NCN)2)(H2O)]·2H2O (2), [(NpO2)(TPTZ)(C(NH2)(NCN)2)]·3H2O (3) and [(NpO2)(iPr-BTP)(C(NH2)(NCN)2)(H2O)] (4). Dicyanoguanidinate anions appear as a result of a transformation of the dicyanamide during the synthesis. The coordination environment of Np atoms in compounds is pentagonal bipyramids with “yl” oxygen atoms in apical positions. The equatorial plane of the bipyramid in 1 and 2 complexes is formed by: two nitrogen atoms from two anions [C(NH2)(NCN)2]−, two nitrogen atoms from neutral ligands Bipy (1) and Phen (2), and an oxygen atom of a water molecule. The equatorial plane of bipyramid 3 is formed by five nitrogen atoms: two atoms from two [C(NH2)(NCN)2]− anions and three atoms from TPTZ. The equatorial plane of bipyramid 4 is formed by one nitrogen atom of the anion, three nitrogen atoms of the iPr-BTP ligand, and an oxygen atom of the water molecule. In compounds 1 – 3, the anion acts as a bidentate-bridging ligand; in compound 4, the anion is a monodentate ligand.
Gender Gap in Bibliometric Indices of Academic and Non-Academic Italian ICU Physicians
Authors: Lembo R. , Losiggio R. , Baiardo Redaelli M. , Belletti A. , Nakhnoukh C. , Bonizzoni M. A. 
Published: October 2024

Hirsch-index, better known as, H-index is an important bibliometric index for Italian critical care physicians. Aim of our study was to collect the H-index of all Italian critical care academic physicians and compare it with the Italian Ministry of University and Research thresholds necessary to be eligible as Professor, and to investigate potential gender disparities in such bibliometric indices. Materials and Methods. We collected all the names of academic ICU physicians on June 24th, 2023 from the official Italian Ministry of University and Research website. We added non-academic ICU physicians searching on Scopus or among academic physicians’ collaborators. Minimum thresholds to be eligible as Professor were identified through the official Italian Ministry of University and Research website. Median H-index of men and women were compared. Results. The total number of included physicians was 237 (46 Full Professors, 88 Associate Professors, 79 Researchers and 22 Non-academic physicians). Minimum threshold to be eligible as Associate Professor was 6 and to be eligible as Full Professor was 13. The median H-index in men versus women in every subgroup was: Full Professors (38 [27–49] vs 29 [21–34]), Associate Professors (25 [18–32] vs 22 [18–28]), Researchers (12 [7–21] vs 9 [6–16]) and Non-academic physicians (27 [25–37] vs 26 [25–29]). Conclusion. Current median H-index of Italian academic ICU physicians is considerably greater than minimum thresholds released by the Italian Ministry of University and Research to be eligible as Professor. Gender gap in bibliometric indices of academic ICU physicians remains.
Канонічне становище та управління Української Автокефальної Православної Церкви в умовах утвердження більшовицького режиму в Україні 1921–1936 років
Authors: Боровський Андрій 
Published: October 2024

Актуальність. Українське церковне будівництво, що взяло своїм початком першу половину ХХ століття, не втратило свою актуальність і в сьогоденні. Глибокі внутрішньо-психологічні та соціальні передумови важливі і по сьогоднішній день.
Метою дослідження є розкриття ролі церковних канонів та історичних обставин в українському церковному будівництві часів утвердження більшовицького режиму в Україні.
Результати. Опинившись в обставинах іноземної окупації та повного відокремлення від держави, український православний церковний рух побудував нову та цілком відмінну від структури, запропонованої в законі про верховне управління Української Православної Автокефальної Синодальної Церкви, прийнятого 1 січня 1919 року за уряду Директорії Української Народної Республіки. В умовах тоталітарного режиму українському церковному рухові доводилося рахуватися з загальним політичним фоном, що на початку 20-тих років ХХ століття сприяв українському церковному відродженню, оскільки той не являв собою помітної сили, а в кінці 20-тих початку 30-тих років знищив його повністю.
Висновки. У зв’язку з обставинами, в яких опинилися українські національні державні утворення першої половини ХХ століття, успіх їх церковних намірів потрапляв в пряму залежність від державотворчих процесів і здатності цих держав до боротьби за їх самостійність і визнання з боку інших держав. Визнання української церкви ставало заручником успіху та визнання українських державних утворень від іноземних держав з одного боку, а з іншого – небажання єпископату становлення національних церковних структур.
Порівняльний аналіз у дослідженні інституційних реформ: можливості та обмеження
Authors: Кобильник Василь 
Published: October 2024

Актуальність. Стаття розглядає актуальну проблематику використання порівняльного аналізу для дослідження інституційних реформ. Порівняльний аналіз є одним із найпоширеніших методів дослідження інституційних реформ. Він дозволяє дослідникам порівнювати та контрастувати інституційні реформи, які були проведені в різних країнах або контекстах. Це може допомогти їм виявити закономірності та фактори, які впливають на успішність або невдачу реформ. Однак порівняльний аналіз є складним методом, який потребує ретельного планування та обережної інтерпретації результатів. Звісно, він не позбавлений своїх обмежень.
Метою дослідження стало визначення потенційних можливостей та обмежень порівняльного аналізу як методу дослідження інституційних реформ.
Результати. Аналізуючи роль порівняльного аналізу в контексті розробки та впровадження інституційних реформ, стаття висвітлює ключові переваги та недоліки застосування даного методу. Виокремлено особливості використання порівняльного аналізу в контексті проведення двох інституційних реформ в Україні: децентралізації влади та реформи банківської системи.
Висновки. У висновку було зазначено, що порівняльний аналіз може бути цінним інструментом для дослідження впровадження інституційних реформ. Він може допомогти дослідникам та політикам отримати ширший погляд, виявити кращі практики, пояснити причини успіху чи невдачі, підвищити обґрунтованість політики, стимулювати інновації та сприяти зростанню знань. Важливо зазначити, що порівняльний аналіз має певні обмеження. Серед них проблеми «субʼєктивної обмеженості» дослідника, обмеженої кількості конкретних прикладів, вибору параметрів для порівняння, функціональної еквівалентності, врахування історичного минулого, верифікації прогнозів дослідження. Крім того, важливо ретельно підбирати країни та випадки для порівняння, щоб зробити обґрунтовані висновки.
“I see two suns” Some remarks on the image of a hallucinating satyr by the Kleophrades Painter (Malibu 85.AE.188)
Authors: Mayer Péter 
Published: October 2024

AbstractThe article considers two fragments of a vase painting by the Kleophrades Painter which display images of a satyr and a sleeping maenad, respectively. Even the words of the satyr are preserved by a fragmentary inscription that largely coincide with those uttered by Pentheus in v. 918 of Euripides' Bacchae. In view of the unique correspondence between picture and play, apparently overlooked by Euripidean scholarship, the study seeks to reevaluate earlier assumptions about the psychological and ritual background of Pentheus' words.
Brown adipose tissue activation in paediatric and adolescent oncological (Hodgkin lymphoma or sarcoma) cases visualised on FDG PET/CT
Authors: Jorgov Linda , Magyar Boglárka , Piroska Márton , Czibor Sándor , Györke Tamás 
Published: October 2024

AbstractObjectiveWe aimed to study the possible factors influencing visualisation of brown adipose tissue (BAT) on FDG PET/CT at diagnosis in children.MethodA total of 92 children or adolescents were included (63 patients with Hodgkin lymphoma (HL) and 29 patients with sarcoma). We examined FDG PET/CT images obtained at diagnosis and searched for FDG uptake in BAT. We analysed the relationship between BAT activation and different possible influencing factors, such as age, sex, outside temperature or season, histological type of malignancy (HL or sarcoma), and volumetric and metabolic values of the tumour tissue. Mann-Whitney, Chi-2 and Fischer's exact tests, and logistic regression analysis were used.ResultsWe found no significant difference in the BAT activation frequency between patients with HL and those with sarcoma (P = 0.12). BAT visualization on FDG PET/CT in the HL subgroup showed a trend towards lower TMTV (P = 0.06) and TLG (P = 0.09).The logistic regression analysis did not show a significant correlation between BAT visualisation on FDG PET/CT and TMTV values.In terms of age, we found a slightly significant correlation for the whole group (P = 0.06) and for the subgroup of HL patients (P = 0.04) in logistic regression. In terms of seasons, the majority (45%) of BAT positive cases were found in autumn.ConclusionsBAT visualisation may be associated with a low HL tumour mass. Multivariate analysis revealed a correlation between BAT activation and age in paediatric patients. BAT visualisation do not differ between boys and girls.
Piezo, Nephrocyte Function, and Slit Diaphragm Maintenance in Drosophila
Authors: Zhao Yunpo , Duan Jianli , Han Iden D. , van de Leemput Joyce , Ray Patricio E. , Han Zhe 
Published: October 2024

Key Points

Piezo channels, known for detecting mechanical pressure, were found to be expressed at the lacuna channel membranes of nephrocytes.Piezo loss of function caused nephrocyte dysfunction, including disrupted slit diaphragm structure and altered lacuna channel morphology.Piezo deficiency led to internalized slit diaphragm proteins, reduced autophagy, increased endoplasmic reticulum stress, and impaired calcium homeostasis.

Background
The Piezo gene encodes a highly conserved cell membrane protein responsible for sensing pressure. The glomerular kidney and the slit diaphragm filtration structure depend on pressure for filtration. However, how Piezo is involved in kidney function and in maintaining the slit diaphragm filtration structure is not clear.

Methods
We used Drosophila pericardial nephrocytes, filtration kidney cells with striking structural and functional similarities to human podocytes, in a loss-of-function model (mutant and knockdown) to study the roles of Piezo in nephrocyte filtration and function.

Results

Piezo was highly expressed at the invaginated membranes (lacuna channels) of nephrocytes. A Piezo loss-of-function mutant showed significant nephrocyte functional decline. Nephrocyte-specific silencing of Piezo showed disruption of the slit diaphragm filtration structure and significant functional defects. Electron microscopy showed that silencing Piezo in nephrocytes led to reduced slit diaphragm density and abnormal shape of lacuna channels. Moreover, the Piezo-deficient nephrocytes showed internalized slit diaphragm component proteins, reduced autophagy, increased endoplasmic reticulum stress, and reduced calcium influx.

Conclusions
Together, our findings suggest that Piezo plays an important role in the calcium homeostasis of nephrocytes and is required for maintaining nephrocyte function and the slit diaphragm filtration structure.
Identifying Opportunities for Developing Nature-Based Sport Tourism to Improve Health in Papua: A Bibliometric Analysis of Research Over Ten Years
Authors: Guntoro Tri Setyo , Prasetyo Yudik , Putra Miftah Fariz Prima , Nurhidayah Dewi , Sinaga Evi , Yuliana Ela , Nanda Fitri Agung 
Published: October 2024

Objectives. This study aimed to examine research trends around nature-based tourism, event-based sports tourism, and their relationship with government policies to identify potential opportunities for sustainable sports tourism development in Papua.
Materials and methods. The methodological approach comprised using a bibliometric analysis by reviewing 997 scientific articles sourced from Scopus, PubMed, and Web of Science databases from 2014-2024. Harzing’s publish or Perish software was used to sort the articles, and VOSViewer software was used to analyze the articles. The review included the number of cluster groups, research themes related to sports tourism in the year groups, research trends around nature-based sports tourism, and gaps in sports tourism development.
Results. There were eight cluster groups and five groups. The current research trends in the field of sports tourism comprise event-based sports tourism, nature tourism, the tourism industry, and social media. The research trends related to nature-based sports tourism include six keywords, namely nature-based tourism, nature connectedness, nature sport, nature-based events, nature-based recreation, and nature. Visitors, managers, communities, and governments benefit from the health and economic advantages of nature-based sports tourism. In developing nature-based sports tourism, it is essential to consider the sustainability of nature, cultural characteristics, and the form of activities offered. Local governments need to take part in efforts to develop and preserve nature-based sports tourism.
Conclusions. The development of nature-based sports tourism with traditional sports activities has a great opportunity to be enhanced. This innovation certainly needs careful planning from determining goals, human resources, risk factors, and presenting an effective promotional strategies. The involvement of local government can facilitate the implementation of this planning.
Analytical study of participation dynamics in healthcare insurance plans for treatment of patients diagnosed with sexually transmitted diseases (STDs)
Authors: Onwuka Osah Martins , Ajuzie Godson Chukwuemeka , Okerulu Adaobi Linda 
Published: October 2024

To conduct an analytical investigation into the dynamics of participation in healthcare insurance plan among individuals diagnosed with Sexually Transmitted Diseases (STDs), aiming to elucidate factors influencing enrollment and engagement. This clinical-based descriptive survey was conducted at a Federal Medical Center, Nigeria; gathering data from pregnant women, nursing mothers, adolescents, and sex workers diagnosed with STDs. Volunteered participants were selected through simple arbitrary sampling. Data were analyzed using a binary probit model, where Pi = 1 if p* &#62; 0, indicates patient is a member of the insurance plan, and Pi = 0 otherwise; with the primary decision criterion based on the average score of insurance plan members. Total of 114 participants responded positively, comprising various demographics; sex workers displayed the highest awareness and participation (90.3%) in the health insurance plan. Conversely, adolescents showed the lowest levels (37.4%), likely due to limited literacy and income. Pregnant and nursing mothers demonstrated relatively high rates (62.6% and 81.5%); possibly due to routine antenatal care. Factors influencing participation include income, religion, literacy, and organizational experience. Marginal coefficients suggest higher participation probabilities for women and older household members, indicating greater hospitalization needs. Membership correlates with more frequent hospitalization at lower costs, influenced by age, STD type, gender, income, and village factors. These findings highlight the intricate nature of participation dynamics in healthcare insurance among individuals diagnosed with STDs. They underscore the significance of mitigating mentioned socioeconomic disparities and demographic factors to promote greater enrollment and engagement in insurance plans.
Prevalence and psychological impact of bone injuries in the hand and forearm
Authors: Faizan MD Adil , Goud Merugu Kumkumeshwar , Gogulamudi Ajay Kumar , Chincholi Sanjeev N 
Published: October 2024

Bone injuries to the hand and forearm, including fractures and amputations, are prevalent and can severely impact individuals' quality of life. These injuries are not only physically debilitating but also carry significant psychological consequences, potentially leading to conditions such as post-traumatic stress disorder (PTSD). Understanding the prevalence of these injuries and their psychological effects is crucial for developing comprehensive treatment and support strategies. This study, conducted at Mamata Medical College, Khammam, from February 2024 to July 2024, included 83 patients aged 18 to 75 years who underwent surgical intervention for hand and forearm bone injuries. Psychological impact was assessed using the Post-Traumatic Stress Disorder Checklist for DSM-5 (PCL-5) at a three-month follow-up. Patients were categorized into PTSD (+) and PTSD (-) groups based on diagnostic criteria and PCL-5 scores. Statistical analyses, including Chi-square tests and T-tests, were performed to explore correlations between injury types, locations, and PTSD. Of the 83 patients, 22 had amputations and 48 had fractures. Among them, 41 (49.4%) met criteria for probable PTSD. A significant association was found between amputation and PTSD (χ²(1) = 8.63, p = .013). Fractures in the index finger, long finger, and ring finger were more strongly correlated with PTSD symptoms (p-values: 0.047, 0.001, and 0.034, respectively). No significant differences were noted for fractures in other locations. This study highlights the substantial psychological impact of bone injuries to the hand and forearm, with nearly half of the patients showing probable PTSD. Amputation, in particular, is significantly associated with increased PTSD risk. Specific fracture locations, such as those in the index finger, long finger, and ring finger, also show a higher correlation with PTSD symptoms.
The Bulgarian State in 927-969. The Epoch of Tsar Peter I
Authors: Brzozowska Zofia A. , Hrissimov Nikolay , Nikolov Georgi N. , Wolski Jan M. , Nikolov Angel , Kaymakamova Miliana 
Published: October 2024

Tsar Peter (927-969), the book’s protagonist, is all too frequently presented in modern scholarship as a weak ruler, devoid of any grander political aspirations, focused on religious matters, indeed – pious, but neglecting the vital interests of his subjects. It was said that during his reign both his court and state became Byzantinised, that the central authority was completely helpless in the face of Hungarian raids, and saw the spread of the Bogomilist heresy. According to the Tsar’s critics, it was as a result of his ineffectual rule that Boris II, his son and successor, was unable to defend Bulgaria’s sovereignty in 971.
This book – the first monograph in world literature devoted to Peter – was written by Bulgarian (Miliana Kaymakamova, Georgi N. Nikolov, Angel Nikolov, Nikolay Hrissimov) and Polish medievalists (Miroslaw J. Leszka, Kirił Marinow, Zofia A. Brzozowska Jan M. Wolski). Thanks to a thorough analysis of the sources and an in-depth knowledge of the literature of the subject, they constructed a comprehensive and balanced image of the reign of their protagonist, and of the role he played in the history of mediaeval Bulgaria.

The research project financed by the National Science Centre. Decision number: DEC-2014/14/M/HS3/00758