bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in breath 13CO2/12CO2 consequent to exercise and hypoxia
Authors: Barstow T. J. , Cooper D. M. , Epstein S. , Wasserman K. 
Published: December 2017

Page 936: T. J. Barstow, D. M. Cooper, S. Epstein, and K. Wasserman. “Changes in breath 13CO2/12CO2 consequent to exercise and hypoxia.” Page 936, right column, sentence beginning on line 8 should read: We therefore wondered if changes in EN could be used to detect changes in endogenous substrate oxidation during exercise. Page 940, right column, sentence beginning on line 15 should read: We controlled for potential acute modulators of oxidative fuel mix (e.g., meal and activity) by the overnight fast and avoidance of strenuous activity 24 h before each test. Page 941, left column, sentence beginning on line 27 should read: In summary, Vo2 adjusts slightly more rapidly than Vco2 in the transition from rest to exercise, whereas 13CO2 adjusts much more slowly. Page 938, Table 3 footnote should read: Values are group means for individual responses averaged from 5 to 20 min of exercise. n = 7 except for WR-3 where n = 6. Hypoxia represented FiO02, = 0.15, room air FiOO2, = 0.207. *Significantly di fferent from both WR-1 conditions and WR-2 in room air (P < 0.05). Note that work above LT (WR-2 in hypoxia and WR-3) resulted in a significant increase in R.
Biomarker-Based Therapy in Pancreatic Ductal Adenocarcinoma: An Emerging Reality?
Authors: Krantz Benjamin A. , O'Reilly Eileen M. 
Published: December 2017

Abstract
Over the last decade, many of the major solid organ cancers have seen improvements in survival due to development of novel therapeutics and corresponding biomarkers that predict treatment efficacy or resistance. In contrast, favorable outcomes remain challenging in pancreatic ductal adenocarcinoma (PDAC), in part related to the lack of validated biomarkers for patient and treatment selection and thus optimal clinical decision-making. Increasingly, however, therapeutic development for PDAC is accompanied by bioassays to evaluate response and to study mechanism of actions with a corresponding increase in the number of trials in mid to late stage with integrated biomarkers. In addition, blood-based biomarkers that provide a measure of disease activity and allow for minimally invasive tumor analyses are emerging, including circulating tumor DNA, exosomes, and circulating tumor cells. In this article, we review potential biomarkers for currently approved therapies as well as emerging biomarkers for therapeutics under development. Clin Cancer Res; 24(10); 2241–50. ©2017 AACR.
Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice
Authors: Duperret Elizabeth K. , Trautz Aspen , Ammons Dylan , Perales-Puchalt Alfredo , Wise Megan C. , Yan Jian , Reed Charles , Weiner David B. 
Published: December 2017

Abstract
Purpose: Fibroblast activation protein (FAP) is overexpressed in cancer-associated fibroblasts and is an interesting target for cancer immune therapy, with prior studies indicating a potential to affect the tumor stroma. Our aim was to extend this earlier work through the development of a novel FAP immunogen with improved capacity to break tolerance for use in combination with tumor antigen vaccines.
Experimental Design: We used a synthetic consensus (SynCon) sequence approach to provide MHC class II help to support breaking of tolerance. We evaluated immune responses and antitumor activity of this novel FAP vaccine in preclinical studies, and correlated these findings to patient data.
Results: This SynCon FAP DNA vaccine was capable of breaking tolerance and inducing both CD8+ and CD4+ immune responses. In genetically diverse, outbred mice, the SynCon FAP DNA vaccine was superior at breaking tolerance compared with a native mouse FAP immunogen. In several tumor models, the SynCon FAP DNA vaccine synergized with other tumor antigen–specific DNA vaccines to enhance antitumor immunity. Evaluation of the tumor microenvironment showed increased CD8+ T-cell infiltration and a decreased macrophage infiltration driven by FAP immunization. We extended this to patient data from The Cancer Genome Atlas, where we find high FAP expression correlates with high macrophage and low CD8+ T-cell infiltration.
Conclusions: These results suggest that immune therapy targeting tumor antigens in combination with a microconsensus FAP vaccine provides two-fisted punch-inducing responses that target both the tumor microenvironment and tumor cells directly. Clin Cancer Res; 24(5); 1190–201. ©2018 AACR.
Evaluating and Improving NWP Forecast Models for the Future: How the Needs of Offshore Wind Energy Can Point the Way
Authors: Banta Robert M. , Pichugina Yelena L. , Brewer W. Alan , James Eric P. , Olson Joseph B. , Benjamin Stanley G. , Carley Jacob R. , Bianco Laura , Djalalova Irina V. , Wilczak James M. , Hardesty R. Michael , Cline Joel , Marquis Melinda C. 
Published: December 2017

AbstractTo advance the understanding of meteorological processes in offshore coastal regions, the spatial variability of wind profiles must be characterized and uncertainties (errors) in NWP model wind forecasts quantified. These gaps are especially critical for the new offshore wind energy industry, where wind profile measurements in the marine atmospheric layer spanned by wind turbine rotor blades, generally 50–200 m above mean sea level (MSL), have been largely unavailable. Here, high-quality wind profile measurements were available every 15 min from the National Oceanic and Atmospheric Administration/Earth System Research Laboratory (NOAA/ESRL)’s high-resolution Doppler lidar (HRDL) during a monthlong research cruise in the Gulf of Maine for the 2004 New England Air Quality Study. These measurements were compared with retrospective NWP model wind forecasts over the area using two NOAA forecast-modeling systems [North American Mesoscale Forecast System (NAM) and Rapid Refresh (RAP)]. HRDL profile measurements quantified model errors, including their dependence on height above sea level, diurnal cycle, and forecast lead time. Typical model wind speed errors were ∼2.5 m s−1, and vector-wind errors were ∼4 m s−1. Short-term forecast errors were larger near the surface—30% larger below 100 m than above and largest for several hours after local midnight (biased low). Longer-term, 12-h forecasts had the largest errors after local sunset (biased high). At more than 3-h lead times, predictions from finer-resolution models exhibited larger errors. Horizontal variability of winds, measured as the ship traversed the Gulf of Maine, was significant and raised questions about whether modeled fields, which appeared smooth in comparison, were capturing this variability. If not, horizontal arrays of high-quality, vertical-profiling devices will be required for wind energy resource assessment offshore. Such measurement arrays are also needed to improve NWP models.
Green light for quantitative live-cell imaging in plants
Authors: Grossmann Guido , Krebs Melanie , Maizel Alexis , Stahl Yvonne , Vermeer Joop E. M. , Ott Thomas 
Published: December 2017

ABSTRACT
Plants exhibit an intriguing morphological and physiological plasticity that enables them to thrive in a wide range of environments. To understand the cell biological basis of this unparalleled competence, a number of methodologies have been adapted or developed over the last decades that allow minimal or non-invasive live-cell imaging in the context of tissues. Combined with the ease to generate transgenic reporter lines in specific genetic backgrounds or accessions, we are witnessing a blooming in plant cell biology. However, the imaging of plant cells entails a number of specific challenges, such as high levels of autofluorescence, light scattering that is caused by cell walls and their sensitivity to environmental conditions. Quantitative live-cell imaging in plants therefore requires adapting or developing imaging techniques, as well as mounting and incubation systems, such as micro-fluidics. Here, we discuss some of these obstacles, and review a number of selected state-of-the-art techniques, such as two-photon imaging, light sheet microscopy and variable angle epifluorescence microscopy that allow high performance and minimal invasive live-cell imaging in plants.
As dimensões dos direitos das águas
Authors: Carli Ana Alice De 
Published: December 2017

The dimensions of the water rights Trata-se o presente texto de uma reflexão acerca da importância de se analisar o líquido vital, a água, a partir de três perspectivas jurídicas, quais sejam: a água como direito fundamental dos seres vivos; a água como titular de direitos; e a água como bem jurídico que necessita de um conjunto de regras e princípios para disciplinar a conduta antrópica, a fim de preservá-la e protegê-la. It is the present text a simple reflection about the importance of analyzing the vital liquid, water, from three legal perspectives, namely: water as a fundamental right of living beings; water as a holder of rights; and the legal water as well that requires a set of rules and principles to regulate the anthropic conduct in order to preserve it and protect it.
Contratos administrativos na União Europeia e no Brasil: uma questão contemporânea comum
Authors: Heinen Juliano 
Published: December 2017

Administrative contracts in the European Union and Brazil: a common contemporary issue O trabalho expõe analiticamente a concepção jurídica e econômica dos contratos administrativos que, no cenário da União Europeia e do Brasil, tornam útil e necessária a construção de um modelo teórico capaz de responder a algumas dificuldades já identificadas. Entre essas dificuldades, pode-se citar a definição do âmbito de aplicação do regime jurídico de direito público e de direito privado, bem como a harmonização de divergências conceituais presentes em diversas modalidades de contratos públicos, promovidas por diferentes entes do poder público como um todo. Assim, a partir da perspectiva contemporânea, são estabelecidos os limites e as possibilidades jurídicas de uma maior ou menor autonomia contratual por parte da administração pública brasileira e europeia. Por fim, é relevante a análise da Diretiva europeia nº 2014/24 como modelo normativo ao desenvolvimento do tema no Brasil. This paper intent to analyze analytically the law and economic conceptions of administrative contracts which, in the context of the European Union and Brazil, make useful and necessary the construction of a theoretical model capable of responding to some difficulties already identified. Among these difficulties, we can cite the definition of the scope of the legal regime of public law and private law; And the harmonization of conceptual differences present in different modalities of public contracts, promoted by different entities of the state as a whole. Thus, from the contemporary perspective, it establishes the legal limits and possibilities of a greater or lesser contractual autonomy on the part of the Brazilian and European Public Administration. Finally, the analysis of European Directive 2014/24 as a normative model for the development of the subject in Brazil is relevant.
A inaplicabilidade parcial dos impedimentos à eleição de conselheiros fiscais em subsidiárias integrais de sociedades de economia mista: a Lei das S.A. e a Nova Lei das Estatais
Authors: Guandalini Junior Walter 
Published: December 2017

Partial inapplicability of the impediments to the election of supervisory board members in subsidiaries wholly owned by mixed capital companies: the Law of Corporations and the New Law of State Companies Este artigo examina os impedimentos à eleição de conselheiros fiscais em sociedades anônimas, sustentando a parcial inaplicabilidade da vedação à eleição de empregados do mesmo grupo para o conselho fiscal de subsidiárias integrais de sociedades de economia mista. Argumenta que nesse modelo societário não há acionistas minoritários a serem protegidos e que não há risco à independência do conselho quando seus membros são empregados da acionista controladora. Conclui que as subsidiárias integrais de sociedades de economia mista não só podem como devem ter, entre os integrantes de seu conselho fiscal, ao menos um empregado público vinculado à sua acionista controladora, como medida de proteção do interesse público e de preservação dos interesses de seu único acionista em face dos órgãos de administração da companhia. This paper examines the impediments to the election of supervisory board members in corporations, advocating the partial inapplicability of the limitations to the election of employees in the same company group to the supervisory board of subsidiaries wholly owned by mixed capital companies. It argues that in this corporate model there are no minority shareholders requiring protection, hence there is no risk to board independence when its members are employees of the controlling shareholder. In conclusion, it demonstrates that subsidiaries wholly owned by mixed capital companies not only can, but also should have, among its supervisory board members, at least one public servant linked to its controlling shareholder, as a measure for protecting both public interest and the interests of its sole shareholder before the company’s management bodies.
B cell, CD8 + T cell and gamma delta T cell infiltration alters alveolar immune cell homeostasis in HIV-infected Malawian adults
Authors: Mwale Andrew , Hummel Annemarie , Mvaya Leonard , Kamng'ona Raphael , Chimbayo Elizabeth , Phiri Joseph , Malamba Rose , Kankwatira Anstead , Mwandumba Henry C , Jambo Kondwani C 
Published: December 2017

Background: HIV infection is associated with increased risk to lower respiratory tract infections (LRTI). However, the impact of HIV infection on immune cell populations in the lung is not well defined. We sought to comprehensively characterise the impact of HIV infection on immune cell populations in the lung.Methods: Twenty HIV-uninfected controls and 17 HIV-1 infected ART-naïve adults were recruited from Queen Elizabeth Central Hospital, Malawi. Immunophenotyping of lymphocyte and myeloid cell populations was done on bronchoalveolar lavage fluid and peripheral blood cells.Results: We found that the numbers of CD8+T cells, B cells and gamma delta T cells were higher in BAL fluid of HIV-infected adults compared to HIV-uninfected controls (all p<0.05). In contrast, there was no difference in the numbers of alveolar CD4+T cells in HIV-infected adults compared to HIV-uninfected controls (p=0.7065). Intermediate monocytes were the predominant monocyte subset in BAL fluid (HIV-, 63%; HIV+ 81%), while the numbers of classical monocytes was lower in HIV-infected individuals compared to HIV-uninfected adults (1 × 105vs. 2.8 × 105cells/100ml of BAL fluid, p=0.0001). The proportions of alveolar macrophages and myeloid dendritic cells was lower in HIV-infected adults compared to HIV-uninfected controls (all p<0.05).Conclusions: Chronic HIV infection is associated with broad alteration of immune cell populations in the lung, but does not lead to massive depletion of alveolar CD4+T cells. Disruption of alveolar immune cell homeostasis likely explains in part the susceptibility for LRTIs in HIV-infected adults.
Thermal adaptation in a marine-derived tropical strain of Fusarium equiseti and polar strains of Pseudogymnoascus spp. under different nutrient sources
Authors: Tajuddin Natasha , Rizman-Idid Mohammed , Convey Peter , Alias Siti Aisyah 
Published: December 2017

Abstract
We documented relative growth rates (RGRs) and activities of extracellular hydrolytic enzymes (EHEs) of one marine-derived tropical strain of Fusarium equiseti originally isolated from Malaysia and two polar strains of Pseudogymnoascus spp. from the Arctic and Antarctic under various temperatures and different nutrient conditions. RGRs and relative enzyme activities (RAs) of protease, amylase and cellulase were screened in seawater nutrient assay plates augmented with either skim milk, soluble starch or carboxymethylcellulose with trypan blue, respectively, across culture temperatures between 5°C and 40°C. Measures of RGR were fitted into third-degree polynomial and Brière-2 temperature-dependent models to estimate optimum temperatures for growth (T
opt) and maximum growth rates (RGR
max), and were used to calculate temperature coefficients (Q
10) and activation energies (Ea
) for growth. All studied strains showed highest RGR and RA when grown using a skim milk nutrient assay. T
opt for growth was 25°C in F. equiseti and 20°C in Pseudogymnoascus spp. Only F. equiseti showed cellulase activity. These data suggest a preference for protein-based substrates over plant-derived substrates for metabolism in these fungal strains. The tropical F. equiseti could utilise higher levels of thermal energy for growth than the polar strains of Pseudogymnoascus spp., implying adaptation of these fungi to different bioclimatic regions.
A Kalman filtering approach to code positioning for GNSS using Cayley-Menger determinants in distance geometry
Authors: Tabatabaee Mohammad Hadi , Ravani Bahram 
Published: December 2017

AbstractThe common approach for code-based point positioning using GNSS involves linearizing the observation equations about an estimated position and solving the equations iteratively in a least squares fashion. The solution provides estimates for the receiver coordinates and clock error. In this paper, a method based on distance geometry and Kalman filtering is presented. Distance geometry is used to provide a closed form solution for the receiver clock bias which is then used to correct the pseudorange observations before proceeding to locate the receiver coordinates. This two step method guarantees a solution for when a minimum of four satellites are available and facilitates direct utilization of a simple Kalman filter without any need for linearization. Results indicate that the method presented can provide improved estimates under poor satellite coverage as compared to the conventional iterative methods while performing similar to the conventional methods when there is good coverage.
Correlation Before Auschwitz
Authors: Stevens William F. 
Published: December 2017

AbstractTheodore Adorno entitled the final section of his book Negative Dialektic “After Auschwitz”. For Adorno, this horror rendered metaphysical speculation incapable of speaking in universal terms. Paul Tillich’s early correlative method led him to speak against the Nazi regime and its persecution of the Jewish race. The practice of this correlative method brought Tillich to critique both the political and the social structure. His method of correlation stands above “metaphysics in its downfall” as he was aware of the negative results long before Auschwitz. This essay contends that Tillich’s methodology called for a new praxis of emancipation.
KNOWLEDGE MANAGEMENT: AN OVERVIEW OF RESEARCH TRENDS
Authors: KÖR Burcu , MUTLUTÜRK Meltem 
Published: December 2017

As a young and interdisciplinary field, Knowledge Management (KM) holds a crucial role in scientific research and development of knowledge-intensive economies. This study elaborates on the methods used in previous studies regarding the research trends of KM and their contribution to the discipline by examining the KM literature. The purpose of the study is to determine the current research trends of KM by analysing KM citation classics and examining their characteristics as well as presenting a holistic framework of KM publications from the results of citation analysis. A total of 152 articles published in peer review journals between the years 2010-2014 were analysed. As a result of the analysis, a holistic KM framework was developed in order to contribute to a consensus of KM field. The results of the study reveals that the coverage of KM articles expanded into a broad spectrum of concepts, disciplines and environment.
KADINLARIN YÖNETİCİ POZİSYONLARINDA YAŞADIKLARI ZORLUKLAR VE LİDER ÜYE ETKİLEŞİMİNDE CİNSİYETİN ROLÜ
Authors: AKDÖL Buket , MENTEŞ Süleyman Ahmet 
Published: December 2017

Bu çalışmada cam tavan ve kraliçe arı sendromunun astlarla yüksek nitelikli etkileşim kurmada olası etkileri irdelenmektedir. Çalışmada yönetici cinsiyetinin çalışanın yöneticiyle etkileşimi açısından anlamlı farklılık yaratıp yaratmadığı da analiz edilmiştir. Araştırmanın sonuçlarına göre, Türk iş hayatında beyaz yakalı çalışanlar arasında, yöneticinin cinsiyetinin yöneticilerinden etkilenme, katkı sağlamaya istekli olma, sadakat ile bağlı olma ve profesyonel olarak saygı duyma ile şekillenen etkileşim düzeyleri açısından anlamlı fark yaratmadığı ortaya konmuştur. Ayrıca çalışanın cinsiyetinin hem kadın hem de erkek yönetici ile etkileşim düzeyi açısından anlamlı fark oluşturmadığı tespit edilmiştir.
Formación docente inicial y acción socioeducativa: Construyendo una propuesta de implementación del Programa Maestros Comunitarios (PMC)
Authors: Barberousse-Alfonso Paulette , Vargas-Dengo Marie Claire , Corrales-Bastos Pamela 
Published: December 2017

From a critical and transformative approach, this essay presents inputs and relevant conclusions obtained during the first stage of the project Construyendo una propuesta de implementación del Programa Maestros Comunitarios (PMC), Code number 0166-15 DEB-UNA (UNA, DEB, s. f.), conducted in 2016. Considering our perspective as researchers and professors at División de Educación Básica, the paper addresses a current topic within the socio-educative field to face challenges of contemporary educational models in formal and non-formal areas of elementary education in the Costa Rican context. Our purpose is that students and teachers of the career program Pedagogía con énfasis en I y II ciclos de la Educación General Básica have an overview of the national, social, and educational reality in an attempt to involve them in applying pedagogical actions towards finding a solution to school dropouts at Escuela Finca Guararí, Heredia, Costa Rica. The essay describes the experience of teaching education students and their socio-educational action with the focus on the systematization of the experience in the initial stage of the project. Furthermore, the paper connects with emerging strategic knowledge areas at División de Educación Básica (DEB), such as social and community pedagogy in the context of the National University (UNA) of Costa Rica. It takes over a route already traced at DEB, which proposes more flexible and alternative pedagogic formats to promote educational equity and diversity issues. The paper describes the project background and a theoretical framework, as well as aspects that have been shared by the protagonist actors along the process: students-teachers, host teachers, supervisor professors, school children, and their parents at Escuela Finca Guararí. Conclusions address main results and facts during 2016 in order to show the viability of the project, which is conducted from a public university. Finally, the article also includes an overview of the project’s future in terms of its implementation in the Costa Rican context.