bluuebunny/crossref_metadata_2025_split huggingface dataset:
The significance of meaningful and enjoyable activities for nursing home resident's experiences of dignity
Authors: Slettebø Åshild , Sæteren Berit , Caspari Synnøve , Lohne Vibeke , Rehnsfeldt Arne Wilhelm , Heggestad Anne Kari Tolo , Lillestø Britt , Høy Bente , Råholm Maj‐Britt , Lindwall Lillemor , Aasgaard Trygve , Nåden Dagfinn 
Published: December 2016

BackgroundLiving in a nursing home may be challenging to the residents’ experience of dignity. Residents’ perception of how their dignity is respected in everyday care is important.AimTo examine how nursing home residents experience dignity through the provision of activities that foster meaning and joy in their daily life.MethodA qualitative design was used and 28 individual semistructured interviews conducted with nursing home residents from six nursing homes in Denmark, Norway and Sweden. The data were analysed with qualitative content analysis. Independent ethical committees in all participating countries granted their approval for the study.FindingsThe participants highlight two dimensions of the activities that foster experiences of dignity in nursing homes in Scandinavia. These two categories were (i) fostering dignity through meaningful participation and (ii) fostering dignity through experiencing enjoyable individualised activities.ConclusionActivities are important for residents to experience dignity in their daily life in nursing homes. However, it is important to tailor the activities to the individual and to enable the residents to take part actively. Nurses should collect information about the resident's preferences for participation in activities at the nursing home.
The HLA‐A, ‐B and ‐DRB1 polymorphism in a large dataset of South Brazil bone marrow donors from Rio Grande do Sul
Authors: Boquett J. A. , Nunes J. M. , Buhler S. , de Oliveira M. Z. , Jobim L. F. , Jobim M. , Fagundes N. J. R. , Schüler‐Faccini L. , Sanchez‐Mazas A. 
Published: December 2016

AbstractHuman leukocyte antigen (HLA) genes are very informative in population genetics studies and their variability has been widely used to reconstruct the history of geographic and/or demographic expansions of human populations. The characterization of HLA diversity at the population level is also fundamental in clinical studies, particularly for bone marrow transplantation programs. In this study, we investigated the HLA molecular variation in Rio Grande do Sul, South Brazil, in order to identify possible regional differences across this state. More than 97,000 bone marrow donors were typed at the HLA‐ A, ‐B and ‐DRB1 loci and analyzed by considering two kinds of subdivisions based on both self‐identified ethnicity and place of residence: (a) the official geographic subdivision defined by the Brazilian Institute of Geography and Statistics and (b) known information about the colonization history of the state. HLA allele and haplotype frequencies were estimated and compared among the defined subgroups. The results indicate a lack of correlation between genetic variation and geography and thus no clear HLA genetic structure based on geographic criteria. On the other hand, major differences were observed regarding ethnicity. In addition, local populations from Rio Grande do Sul were found to be genetically similar to their corresponding parental European populations from Germany, Italy and Portugal, as documented by historical data. Overall, this study provides a thorough characterization of the HLA genetic variation in Rio Grande do Sul and a better understanding of its demographic history, being most useful for the development of more efficient strategies in bone marrow donors' recruitment.
Multidisciplinary inferences on a newly recognized active east‐dipping extensional system in Central Italy
Authors: Lavecchia Giusy , Adinolfi Guido Maria , de Nardis Rita , Ferrarini Federica , Cirillo Daniele , Brozzetti Francesco , De Matteis Raffaella , Festa Gaetano , Zollo Aldo 
Published: December 2016

AbstractWe use a multidisciplinary approach to gather preliminary evidence for a Quaternary east‐dipping extensional detachment in Central Italy. This structure crops out in the Sabini‐Eastern Simbruini (SES) and would be hidden at mid‐crustal depths beneath the L'Aquila 2009 (Mw6.3) epicentral area. TheSESgeometry is reconstructed through geological mapping, structural analysis and seismic line interpretation. The geometry of the mid‐crustal segment, referred to as the Ocre Segment (OS), is interpreted through seismological analyses of the largest aftershock (Mw5.4) of the L'Aquila 2009 sequence. The kinematic compatibility between theSESand theOSunder a commonSW–NEtensional field is tested through stress inversion of both geological and seismological data. The reliability ofOSactivation is tested through slip tendency analysis. Like other Italian cases, theSESand theOSare preliminarily interpreted as expressions at different depths of the same unknown east‐dipping extensional detachment, characterized by a ramp–flat–ramp geometry.
Use of organs from donors with bloodstream infection, pneumonia, and influenza: Results of a survey of infectious diseases practitioners
Authors: Mehta Sanjay R. , Logan Cathy , Kotton Camille N. , Kumar Deepali , Aslam Saima 
Published: December 2016

AbstractBackgroundPotential organ donors may be admitted with an infection to an intensive care unit, or contract a nosocomial infection during their stay, increasing the risk of potential transmission to the recipient. Because of a lack of practice guidelines and large‐scale data on this topic, we undertook a survey to assess the willingness of transplant infectious diseases (ID) physicians to accept such organs.MethodsWe performed a 10‐question survey of ID providers from the American Society of Transplantation Infectious Disease Community of Practice to determine the scope of practice regarding acceptance of organs from donors with bloodstream infection, pneumonia, and influenza prior to organ procurement, as well as management of such infections following transplantation.ResultsAmong 60 respondents to our survey, a majority indicated that organs would be accepted from donors bacteremic with streptococci (76%) or Enterobacteriaceae (73%) without evidence of drug resistance. Acceptance rates varied based on infecting organism, type of organ, and center size. Ten percent of respondents would accept an organ from a donor bacteremic with a carbapenem‐resistant organism. Over 90% of respondents would accept an organ other than a lung from a donor with influenza on treatment, compared with 52% that would accept a lung in the same setting.ConclusionsThis study is the first to our knowledge to survey transplant ID providers regarding acceptance of organs based on specific infections in the donor. These decisions are often based on limited published data and experience. Better characterization of the outcomes from donors with specific types of infection could lead to liberalization of organ acceptance practices across centers.
West Nile Virus preparedness plan to ensure safe blood components in Switzerland: a risk‐based approach
Authors: Niederhauser C. , Fontana S. , Glauser A. , Steinemann C. , Koller A. 
Published: December 2016

BackgroundIn 2012, the Swiss Transfusion SRC founded a working group to develop a WNV preparedness plan for Switzerland in order to deal with expanding spread of WNV epidemics in Europe.Materials and MethodsThe risk estimates were computed for various presumptive incidence scenarios and brought into relation to cost estimates for the introduction of a routine WNV‐NAT screening programme. The costs to prevent one case per year and the number of donations which need to be tested to detect a WNV‐RNA‐positive donation were calculated.ResultsWith a theoretical postulated incidence of one West Nile virus meningoencephalitis (WNVME) case in Switzerland per year, approximately one WNV‐RNA‐positive case would be detected every 11 years. With 100 WNVME cases per year, approximately 8·8 donations would be detected every year. The additional cost burden of introducing WNV‐NAT in Switzerland is 2·6 million euros per year. Costs to prevent one case per year are thus between 27 million and 0·28 million euros, depending on the incidence assumption.Due to the geographical situation in Switzerland, it was decided to determine two potential risk regions, the southern part of the country and the remaining northern part. In addition, two risk levels and respective measures were defined.ConclusionsThe risk for WNV transmission through blood products is low even when 100 autochthonous WNV cases would be detected. With this in mind, the blood transfusion services and the national health authorities established a cost‐efficient WNV preparedness plan to prevent WNV transfusion–transmission and maintain self‐sufficiency in the blood supply.
IMAGING DIAGNOSIS—IMAGING AND HISTOPATHOLOGIC CHARACTERISTICS OF A VERTEBRAL HAMARTOMA IN A CAT
Authors: Taylor‐Brown Frances E. , Lamb Christopher R. , Martineau Henny , Muir Clare , Beltran Elsa 
Published: December 2016

AbstractA 9‐month‐old domestic shorthair cat had progressive ambulatory paraparesis, proprioceptive ataxia, and thoracolumbar hyperesthesia. An extradural mass affecting the left pedicle and lamina of the second lumbar vertebra (L2) causing marked spinal cord impingement was identified in magnetic resonance (MR) images. The mass was predominantly calcified in computed tomographic (CT) images. A hemilaminectomy was performed to resect the mass. Clinical signs were greatly improved at 12‐month follow‐up. The histopathologic diagnosis was vascular hamartoma. To our knowledge, this is the first report describing the MR characteristics of a vascular hamartoma associated with the vertebral column.
Molecular diversity and distribution of eastern Atlantic and Mediterranean dogfishes Squalus highlight taxonomic issues in the genus
Authors: Veríssimo Ana , Zaera‐Perez Diana , Leslie Rob , Iglésias Samuel P. , Séret Bernard , Grigoriou Panagiotis , Sterioti Aspasia , Gubili Chrysoula , Barría Claudio , Duffy Clinton , Hernández Sebastián , Batjakas Ioannis E. , Griffiths Andrew M. 
Published: December 2016

The alpha taxonomy of the globally distributed shark genus Squalus has been under intense investigation recently, and many new species have been described over the last decade. However, taxonomic uncertainty remains about several taxa. Without consistent nomenclature and the ability to reliably distinguish between the different Squalus species, basic data collection, downstream conservation and management efforts are seriously compromised. To aid in clarifying the taxonomic status of Squalus species in the eastern Atlantic and Mediterranean, we assessed species diversity at the molecular level and evaluated the consistency in species identification in the region. Samples from all nominal Squalus species recognized in the above regions were collected in an international effort and sequenced for regions of the mitochondrial COI and ND2 genes. These data were further analysed alongside publicly available sequences, including 19 of the 26 Squalus species globally recognized, to compare the regional genus‐level diversity with that found elsewhere. Our results confirm inconsistent species identification in the eastern Atlantic and Mediterranean Squalus, particularly concerning S. blainville and S. megalops, and reinforce the need to revise the status of S. megalops and S. mitsukurii as they may include several distinct species distributed around the world. The status of S. blainville is also discussed in the light of the current findings and its problematic taxonomic history.
Draft Genome Sequences of Campylobacter jejuni Strains That Cause Abortion in Livestock
Authors: Weis Allison M. , Clothier Kristin A. , Huang Bihua C. , Kong Nguyet , Weimer Bart C. 
Published: December 2016

ABSTRACTCampylobacter jejuniis an intestinal bacterium that can cause abortion in livestock. This publication announces the public release of 15Campylobacter jejunigenome sequences from isolates linked to abortion in livestock. These isolates are part of the 100K Pathogen Genome Project and are from clinical cases at the University of California (UC) Davis.
Copenhagen five-second squeeze: a valid indicator of sports-related hip and groin function
Authors: Thorborg K , Branci S , Nielsen M P , Langelund M T , Hölmich P 
Published: December 2016

BackgroundNo simple clinical measure exits to evaluate groin pain and its severity in athletes. The aim was to investigate the validity, reliability and responsiveness of a five-second hip-adduction squeeze test for football players designed to assess sports-related hip and groin function, pain and severity.MethodsConstruct validity was assessed in 667 subelite male football players with a mean age (±SD) of 24±4 in the beginning of the season. Responsiveness and reliability were evaluated during the season in 52 and 10 players, respectively. Players answered the Copenhagen Hip and Groin Outcome Score (HAGOS) and performed the Copenhagen five-second squeeze assessed on a Numerical Pain Rating Scale (NRS) ranging from 0 to 10.ResultsAs hypothesised higher pain scores during the Copenhagen five-second squeeze correlated significantly (Spearman's rho=−0.61, p<0.01) with a lesser HAGOS (Sport) Score. The change scores in the Copenhagen five-second squeeze also correlated significantly (Spearman's rho=−0.51, p<0.01), with HAGOS (Sport) change scores in the responsiveness analysis, and test–retest reliability (concordance correlation coefficient) was 0.90. Moreover, significant (p<0.01) between-group differences existed for HAGOS (Sport) Scores in players reporting groin pain intensity at one of the 3 different pain levels: NRS (0–2), NRS (3–5) and NRS (6–10). The NRS (6–10) group had the lowest median (IQR) HAGOS (Sport) Score of 47 (31–61).ConclusionsThe Copenhagen five-second squeeze is a valid indicator of sports-related hip and groin function in football players. Players reporting groin pain intensity as 6 of 10 or more in the Copenhagen five-second squeeze experience substantially impaired sports-related hip and groin function.
Predicting sport and occupational lower extremity injury risk through movement quality screening: a systematic review
Authors: Whittaker Jackie L , Booysen Nadine , de la Motte Sarah , Dennett Liz , Lewis Cara L , Wilson Dave , McKay Carly , Warner Martin , Padua Darin , Emery Carolyn A , Stokes Maria 
Published: December 2016

BackgroundIdentification of risk factors for lower extremity (LE) injury in sport and military/first-responder occupations is required to inform injury prevention strategies.ObjectiveTo determine if poor movement quality is associated with LE injury in sport and military/first-responder occupations.Materials and methods5 electronic databases were systematically searched. Studies selected included original data; analytic design; movement quality outcome (qualitative rating of functional compensation, asymmetry, impairment or efficiency of movement control); LE injury sustained with sport or military/first-responder occupation. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were followed. 2 independent authors assessed the quality (Downs and Black (DB) criteria) and level of evidence (Oxford Centre of Evidence-Based Medicine model).ResultsOf 4361 potential studies, 17 were included. The majority were low-quality cohort studies (level 4 evidence). Median DB score was 11/33 (range 3–15). Heterogeneity in methodology and injury definition precluded meta-analyses. The Functional Movement Screen was the most common outcome investigated (15/17 studies). 4 studies considered inter-relationships between risk factors, 7 reported diagnostic accuracy and none tested an intervention programme targeting individuals identified as high risk. There is inconsistent evidence that poor movement quality is associated with increased risk of LE injury in sport and military/first-responder occupations.ConclusionsFuture research should focus on high-quality cohort studies to identify the most relevant movement quality outcomes for predicting injury risk followed by developing and evaluating preparticipation screening and LE injury prevention programmes through high-quality randomised controlled trials targeting individuals at greater risk of injury based on screening tests with validated test properties.
Decision tree-based modelling for identification of potential interactions between type 2 diabetes risk factors: a decade follow-up in a Middle East prospective cohort study
Authors: Ramezankhani Azra , Hadavandi Esmaeil , Pournik Omid , Shahrabi Jamal , Azizi Fereidoun , Hadaegh Farzad 
Published: December 2016

ObjectiveThe current study was undertaken for use of the decision tree (DT) method for development of different prediction models for incidence of type 2 diabetes (T2D) and for exploring interactions between predictor variables in those models.DesignProspective cohort study.SettingTehran Lipid and Glucose Study (TLGS).MethodsA total of 6647 participants (43.4% men) aged >20 years, without T2D at baselines ((1999–2001) and (2002–2005)), were followed until 2012. 2 series of models (with and without 2-hour postchallenge plasma glucose (2h-PCPG)) were developed using 3 types of DT algorithms. The performances of the models were assessed using sensitivity, specificity, area under the ROC curve (AUC), geometric mean (G-Mean) and F-Measure.Primary outcome measureT2D was primary outcome which defined if fasting plasma glucose (FPG) was ≥7 mmol/L or if the 2h-PCPG was ≥11.1 mmol/L or if the participant was taking antidiabetic medication.ResultsDuring a median follow-up of 9.5 years, 729 new cases of T2D were identified. The Quick Unbiased Efficient Statistical Tree (QUEST) algorithm had the highest sensitivity and G-Mean among all the models for men and women. The models that included 2h-PCPG had sensitivity and G-Mean of (78% and 0.75%) and (78% and 0.78%) for men and women, respectively. Both models achieved good discrimination power with AUC above 0.78. FPG, 2h-PCPG, waist-to-height ratio (WHtR) and mean arterial blood pressure (MAP) were the most important factors to incidence of T2D in both genders. Among men, those with an FPG≤4.9 mmol/L and 2h-PCPG≤7.7 mmol/L had the lowest risk, and those with an FPG>5.3 mmol/L and 2h-PCPG>4.4 mmol/L had the highest risk for T2D incidence. In women, those with an FPG≤5.2 mmol/L and WHtR≤0.55 had the lowest risk, and those with an FPG>5.2 mmol/L and WHtR>0.56 had the highest risk for T2D incidence.ConclusionsOur study emphasises the utility of DT for exploring interactions between predictor variables.
Algorithm for predicting death among older adults in the home care setting: study protocol for the Risk Evaluation for Support: Predictions for Elder-life in the Community Tool (RESPECT)
Authors: Hsu Amy T , Manuel Douglas G , Taljaard Monica , Chalifoux Mathieu , Bennett Carol , Costa Andrew P , Bronskill Susan , Kobewka Daniel , Tanuseputro Peter 
Published: December 2016

IntroductionOlder adults living in the community often have multiple, chronic conditions and functional impairments. A challenge for healthcare providers working in the community is the lack of a predictive tool that can be applied to the broad spectrum of mortality risks observed and may be used to inform care planning.ObjectiveTo predict survival time for older adults in the home care setting. The final mortality risk algorithm will be implemented as a web-based calculator that can be used by older adults needing care and by their caregivers.DesignOpen cohort study using the Resident Assessment Instrument for Home Care (RAI-HC) data in Ontario, Canada, from 1 January 2007 to 31 December 2013.ParticipantsThe derivation cohort will consist of ∼437 000 older adults who had an RAI-HC assessment between 1 January 2007 and 31 December 2012. A split sample validation cohort will include ∼122 000 older adults with an RAI-HC assessment between 1 January and 31 December 2013.Main outcome measuresPredicted survival from the time of an RAI-HC assessment. All deaths (n≈245 000) will be ascertained through linkage to a population-based registry that is maintained by the Ministry of Health in Ontario.Statistical analysisProportional hazards regression will be estimated after assessment of assumptions. Predictors will include sociodemographic factors, social support, health conditions, functional status, cognition, symptoms of decline and prior healthcare use. Model performance will be evaluated for 6-month and 12-month predicted risks, including measures of calibration (eg, calibration plots) and discrimination (eg, c-statistics). The final algorithm will use combined development and validation data.Ethics and disseminationResearch ethics approval has been granted by the Sunnybrook Health Sciences Centre Review Board. Findings will be disseminated through presentations at conferences and in peer-reviewed journals.Trial registration numberNCT02779309, Pre-results.
Association between organisational and workplace cultures, and patient outcomes: systematic review protocol
Authors: Braithwaite J , Herkes J , Ludlow K , Lamprell G , Testa L 
Published: December 2016

IntroductionDespite widespread interest in the topic, no current synthesis of research is available analysing the linkages between organisational or workplace cultures on the one hand, and patient outcomes on the other. This protocol proposes a systematic review to analyse and synthesise the literature to date on this topic. The resulting review will discuss characteristics of included studies in terms of the type of healthcare settings researched, the measurements of organisational and workplace culture, patient outcomes measured and the influence of these cultures on patient outcomes.Methods and analysisA systematic review will be conducted aiming to examine the associations between organisational and workplace cultures, and patient outcomes, guided by the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement. An English language search of abstracts will be executed using the following academic databases: CINAHL, EMBASE, Ovid MEDLINE, Web of Science and PsycINFO. The review will include relevant peer-reviewed articles from randomised controlled trials (RCTs), non-RCTs, controlled before and after studies, interrupted time series studies, cross-sectional analyses, qualitative studies and mixed-method studies. Multiple researchers will be involved in assessing the quality of articles for inclusion in the review. This protocol documents a detailed search strategy, including terms and inclusion criteria, which will form the basis of the subsequent systematic review.Ethics and disseminationEthics approval is not required as no primary data will be collected. Results will be disseminated through a peer-reviewed publication and conference presentations.