bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diversidade cultural, produção de subjetividade e infância: pensando o cotidiano na educação infantil
Authors: Siqueira Kassia de Oliveira Martins , Bueno Marina , Souza Taís 
Published: May 2017

ResumoO presente artigo tem como objetivo problematizar o cotidiano na educação infantil e sua relação com o discurso contemporâneo sobre a infância, colocando em análise a definição atual de criança presente nas políticas públicas e nas legislações no âmbito da educação. A análise proposta tem como ponto de partida a experiência de uma das autoras em uma creche situada no município do Rio de Janeiro, de onde são apontados alguns elementos constitutivos das políticas públicas de educação e seus discursos sobre infância, sobretudo aqueles que enquadram o “ser criança” pelo que lhe falta, pelo que não sabem/fazem/conhecem, desconsiderando-as em suas singularidades. A metodologia escolhida para esse estudo é a pesquisa-intervenção, ferramenta da Análise Institucional, em que o conhecimento se produz a partir da problematização das intervenções do pesquisador e de suas implicações com o objeto de pesquisa. Como referências teóricas são utilizadas fundamentalmente as abordagens de Amarante (2012), Foucault (2004) e Guattari e Rolnik (1986).Palavras-chave: diversidade; cultura; infância; cotidiano; subjetividade.Cultural diversity, subjectivity production and childhood: thinking the daily life in early childhood educationAbstractThis article aims to discuss the daily life in early childhood education and its relation to the contemporary discourse about childhood, taking into question the current definition of child that is found in public policy and legislation of the field of education.The proposed analysis takes as it’s starting point the experience of one of the authors at a daycare center in the municipality of Rio de Janeiro, from which some constituent elements of public education policies and their speeches about childhood are pointed, especially those which take the "child being" for what they lack, for what they do not know/do, disregarding them in their singularities.The methodology chosen for this study is the research-intervention, Institutional Analysis tool, from which knowledge is produced from the questioning of the interventions of the researcher and its implications with the research object.Keywords: diversity; culture; childhood; everyday; subjectivity.
As contribuições do lúdico no processo de desenvolvimento das crianças com Síndrome de Down na educação infantil
Authors: Cintra Rosana Carla , Veiga Elaine Cristina , Oliveira Allyne Nunes 
Published: May 2017

ResumoO presente estudo tem por objetivo analisar os subsídios da ludicidade no processo de ensino e aprendizagem de crianças com Síndrome de Down, com enfoque principal nas contribuições da dança. Uma das melhores formas de estimulação para as crianças com síndrome de Down é através das atividades e brincadeiras lúdicas que envolvam as diversas linguagens artísticas como a dança, a música, o teatro e o movimento. A inclusão na rede de ensino é um direito da pessoa com deficiência, sendo assegurado por meio da Lei nº 7.853/89, que decreta a obrigatoriedade do fornecimento de vagas na rede regular de ensino para crianças deficientes. Para tanto adotamos a abordagem qualitativa com levantamento bibliográfico, utilizando como base teórica os autores Vygotsky (2001), Silva (2005), Coutinho (2001) e o Referencial Curricular para a Educação Infantil (1998), tendo como viés teórico-metodológico a perspectiva histórico-cultural. A partir da pesquisa realizada concluímos que a inclusão e o desenvolvimento de crianças com síndrome de Down é de suma importância em ambientes lúdicos, sendo possível trabalhar atividades que estimule seu desenvolvimento de forma prazerosa, sem sercansativo para a mesma e ao mesmo tempo estimulando sua autonomia.Palavras-chave: educação inclusiva; Síndrome de Down; educação infantil.The contributions of ludic in development of children with down syndrome in early childhood educationAbstractThis study aims to analyze the playfulness of subsidies in the teaching and learning of children with Down syndrome, with main focus on dance contributions. One of the best forms of stimulation for children with Down syndrome is through the activities and playful banter involving the variety of artistic expressions such as dance, music, theater and movement. The inclusion in the school system is a right of people with disabilities, being carried out by way of Law No. 7,853 / 89 decrees the mandatory supply of vacancies in mainstream education for disabled children. For both, we chose a qualitative research with literature, using as theoretical basis the authors Vygotsky (2001), Silva (2005), Coutinho (2001) and the Curriculum Reference for Early Childhood Education (1998), with the theoretical and methodological bias in cultural-historical perspective. The survey led us to conclude that the inclusion and the development of children with Down syndrome is of paramount importance in recreational environments, and can work activities that stimulate their development in a pleasant way, without being tiring for the same and at the same time stimulating their autonomy.Keywords: inclusive education; Down's Syndrome; early childhood education.
Nebular Continuum and Line Emission in Stellar Population Synthesis Models
Authors: Byler Nell , Dalcanton Julianne J. , Conroy Charlie , Johnson Benjamin D. 
Published: May 2017

Abstract
Accounting for nebular emission when modeling galaxy spectral energy distributions (SEDs) is important, as both line and continuum emissions can contribute significantly to the total observed flux. In this work, we present a new nebular emission model integrated within the Flexible Stellar Population Synthesis code that computes the line and continuum emission for complex stellar populations using the photoionization code Cloudy. The self-consistent coupling of the nebular emission to the matched ionizing spectrum produces emission line intensities that correctly scale with the stellar population as a function of age and metallicity. This more complete model of galaxy SEDs will improve estimates of global gas properties derived with diagnostic diagrams, star formation rates based on Hα, and physical properties derived from broadband photometry. Our models agree well with results from other photoionization models and are able to reproduce observed emission from H ii regions and star-forming galaxies. Our models show improved agreement with the observed H ii regions in the Ne iii/O ii plane and show satisfactory agreement with He ii emission from z = 2 galaxies, when including rotating stellar models. Models including post-asymptotic giant branch stars are able to reproduce line ratios consistent with low-ionization emission regions. The models are integrated into current versions of FSPS and include self-consistent nebular emission predictions for MIST and Padova+Geneva evolutionary tracks.
WL 17: A Young Embedded Transition Disk
Authors: Sheehan Patrick D. , Eisner Josh A. 
Published: May 2017

Abstract
We present the highest spatial resolution ALMA observations to date of the Class I protostar WL 17 in the ρ Ophiuchus L1688 molecular cloud complex, which show that it has a 12 au hole in the center of its disk. We consider whether WL 17 is actually a Class II disk being extincted by foreground material, but find that such models do not provide a good fit to the broadband spectral energy distribution (SED) and also require such high extinction that it would presumably arise from dense material close to the source, such as a remnant envelope. Self-consistent models of a disk embedded in a rotating collapsing envelope can nicely reproduce both the ALMA 3 mm observations and the broadband SED of WL 17. This suggests that WL 17 is a disk in the early stages of its formation, and yet even at this young age the inner disk has been depleted. Although there are multiple pathways for such a hole to be created in a disk, if this hole was produced by the formation of planets it could place constraints on the timescale for the growth of planets in protoplanetary disks.
Antiviral Therapy Reduces Risk of Haemorrhagic Stroke in Patients with HCV Infection: A Nationwide Cohort Study
Authors: Lin Ming-Shyan , Chung Chang-Min , Lin Wey-Yil , Wei Kuo-Liang , Wang Jui , Lee Ying-Ying , Hu Jing-Hong , Tung Tao-Hsin , Lin Yu-Sheng 
Published: May 2017

Background The tendency for haemorrhagic stroke in patients with chronic HCV infection has emerged recently but the finding may be confounded by comorbidities. Proving the causality between HCV infection and haemorrhagic stroke is mandatory. Our study was designed to investigate the incidence of intracranial haemorrhage in HCV-infected patients with and without treatment. Methods In the 11-year and population-based retrospective study, we acquired data from the Taiwan National Health Insurance Research Database. The patients with major comorbidities were excluded and 97,198 HCV-infected patients were included for analysis. Treated and untreated cohorts were matched with propensity score to make the confounding factors in two groups comparable. Cox proportional hazard regression analysis was performed to evaluate the hazard ratio of haemorrhagic stroke in the cohorts. We applied survival analysis to compare the cumulative incidence of outcome events between the two cohorts. Results After matching, the incidence density (ID) of haemorrhagic stroke in the untreated cohort is significantly higher than in the treated cohort (ID: 1.0 versus 0.6 events per 1,000 person-years; P=0.0014). The adjusted hazard ratio (aHR) of haemorrhagic stroke is significantly reduced in the treated group ( P<0.05). Cumulative incidence of haemorrhagic stroke is significantly lower in the treated group than in the untreated group ( P=0.013). Conclusions The study demonstrates that antiviral therapy significantly reduces the events of intracranial haemorrhage in HCV-infected patients and consolidates the novel concept that chronic HCV infection is a risk factor for haemorrhagic stroke.
La découverte d’un nouvel enlumineur rouennais : le Maître de l’Arsenal
Authors: Chenu Rachel 
Published: May 2017

Alors que jusqu’à aujourd’hui l’historiographie normande faisait une place prédominante au Maître de l’Échevinage de Rouen, la découverte d’un nouvel artiste rouennais, le Maître de l’Arsenal, témoigne de la diversité de la production enluminée à Rouen au xv e siècle. Cet enlumineur à l’identité stylistique bien marquée, qui allie subtilement précision et suggestion, habileté et maladresse, atteste l’activité d’ateliers modestes, à la fois en charge du décor marginal et des miniatures.
Le chevalier de Jaucourt, un combattant des Lumières
Authors: Ferenczi Thomas 
Published: May 2017

Il n’est pas le plus connu des collaborateurs de l’ Encyclopédie mais il est à coup sûr le plus prolifique, avec plus de 17 000 articles de sa main, et l’un des plus fidèles à l’entreprise, qu’il a soutenue jusqu’à son terme, malgré les pressions et les censures. Admirateur de Voltaire, ami de Montesquieu, compagnon de Diderot, le chevalier Louis de Jaucourt (1704-1780) incarne l’esprit des Lumières. Cet aristocrate libéral, protestant d’éducation, médecin de formation, philosophe de vocation, réformateur de conviction, appelle à la lutte contre la superstition et le fanatisme, au combat contre l’intolérance, à la défense de la raison. Il dénonce la monarchie absolue et plaide pour une monarchie limitée, qui respecte la souveraineté du peuple et les droits des citoyens.
Envelhecimento : activo ? bem sucedido ? saudável ? possíveis coordenadas de análise…
Authors: Almeida Mariana F. 
Published: May 2017

Que concepção ou visão do envelhecimento poderá guiar a formulação de políticas, a actuação e a investigação ? Diversos termos têm surgido nas últimas décadas, alguns correspondendo a propostas conceptuais claramente estruturadas, outros nem tanto... Abordar-se-ão aqui alguns dos mais divulgados – envelhecimento saudável, envelhecimento bem sucedido, envelhecimento activo –, discutindo as suas potencialidades e limites. Adoptando como referência uma perspectiva de promoção da saúde, tal como decorre da Carta de Ottawa (1986), termina-se com uma proposta de critérios a ter em conta numa conceptualização de envelhecimento.
L’intérêt de conserver un espace vert de loisirs : un objet de recherche à part entière
Authors: Birks Charlotte 
Published: May 2017

Afin d’expliquer l’intérêt des propriétaires pour la conservation d’espaces verts (semi-naturels), il est souvent fait référence à des termes génériques pratiques, en invoquant, par exemple, des intérêts touristiques, environnementaux, politiques, culturels ou patrimoniaux. À force d’être employés, ces termes finissent presque par perdre les significations pourtant différentes qu’ils peuvent revêtir à l’échelle locale, en fonction des propriétaires des lieux et des contextes dans lesquels ils s’inscrivent. Face à ce constat, le présent article se propose de mettre en perspective la notion de conservation d’espaces verts et d’étudier les conditions d’émergence de ces intérêts de sauvegarde, à partir de l’étude de trois types de propriétaires/gestionnaires d’espaces végétalisés : une entreprise privée de grande distribution, une municipalité et une famille de la noblesse française. Leur point commun réside dans la volonté d’y développer des activités de loisirs d’extérieur. Une démarche ethnographique a été menée sur chacun de ces trois sites, comprenant des enquêtes par entretiens auprès des gestionnaires ainsi qu’une recherche de données historiques. Derrière un même intérêt a priori commun d’ordre touristique (ouvrir au public, favoriser des activités de détente de plein air, répondre aux attentes, etc.), se révèlent trois histoires différentes d’intérêts complexes qui se renforcent, s’officialisent et se collectivisent au fil du temps.
IL-1R Type 1–Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection
Authors: Tian Tian , Jin Michelle Qiushuang , Dubin Krista , King Sandra L. , Hoetzenecker Wolfram , Murphy George F. , Chen Chen Amy , Kupper Thomas S. , Fuhlbrigge Robert C. 
Published: May 2017

Abstract
The IL-1 superfamily of cytokines and receptors has been studied extensively. However, the specific roles of IL-1 elements in host immunity to cutaneous viral infection remain elusive. In this study, we applied vaccinia virus (VACV) by scarification to IL-1R1 knockout mice (IL-1R1−/−) and found that these mice developed markedly larger lesions with higher viral genome copies in skin than did wild-type mice. The phenotype of infected IL-1R1−/− mice was similar to eczema vaccinatum, a severe side effect of VACV vaccination that may develop in humans with atopic dermatitis. Interestingly, the impaired cutaneous response of IL-1R1−/− mice did not reflect a systemic immune deficiency, because immunized IL-1R1−/− mice survived subsequent lethal VACV intranasal challenge, or defects of T cell activation or T cell homing to the site of inoculation. Histologic evaluation revealed that VACV infection and replication after scarification were limited to the epidermal layer of wild-type mice, whereas lack of IL-1R1 permitted extension of VACV infection into dermal layers of the skin. We explored the etiology of this discrepancy and determined that IL-1R1−/− mice contained significantly more macrophages and monocyte-derived dendritic cells in the dermis after VACV scarification. These cells were vulnerable to VACV infection and may augment the transmission of virus to adjacent skin, thus leading to larger skin lesions and satellite lesions in IL-1R1−/− mice. These results suggest new therapeutic strategies for treatment of eczema vaccinatum and inform assessment of risks in patients receiving IL-1 blocking Abs for treatment of chronic inflammatory disorders.
Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production
Authors: Olson Matthew R. , Ulrich Benjamin J. , Hummel Sarah A. , Khan Ibrahim , Meuris Brice , Cherukuri Yesesri , Dent Alexander L. , Janga Sarath Chandra , Kaplan Mark H. 
Published: May 2017

Abstract
IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells. Although IL-2 is produced by all polarized Th subsets to some level, how it impacts cytokine production when effector T cells are restimulated is unknown. We show in this article that Golgi transport inhibitors (GTIs) blocked IL-9 production. Mechanistically, GTIs blocked secretion of IL-2 that normally feeds back in a paracrine manner to promote STAT5 activation and IL-9 production. IL-2 feedback had no effect on Th1- or Th17-signature cytokine production, but it promoted Th2- and Th9-associated cytokine expression. These data suggest that the use of GTIs results in an underestimation of the presence of type 2 cytokine–secreting cells and highlight IL-2 as a critical component in optimal cytokine production by Th2 and Th9 cells in vitro and in vivo.
Tolerogenic versus Immunogenic Lipidomic Profiles of CD11c+ Immune Cells and Control of Immunogenic Dendritic Cell Ceramide Dynamics
Authors: Ocaña-Morgner Carlos , Sales Susanne , Rothe Manuela , Shevchenko Andrej , Jessberger Rolf 
Published: May 2017

Abstract
Lipids affect the membrane properties determining essential biological processes. Earlier studies have suggested a role of switch-activated protein 70 (SWAP-70) in lipid raft formation of dendritic cells. We used lipidomics combined with genetic and biochemical assays to analyze the role of SWAP-70 in lipid dynamics. TLR activation using LPS as a ligand represented a pathogenic immunogenic stimulus, physical disruption of cell–cell contacts a tolerogenic stimulus. Physical disruption, but not LPS, caused an increase of phosphatidylcholine ether and cholesteryl esters in CD11c+ immune cells. An increase of ceramide (Cer) was a hallmark for LPS activation. SWAP-70 was required for regulating the increase and localization of Cers in the cell membrane. SWAP-70 controls Cer accumulation through the regulation of pH-dependent acid-sphingomyelinase activity and of RhoA-dependent transport of endosomal contents to the plasma membrane. Poor accumulation of Cers in Swap70−/− cells caused decreased apoptosis. This shows that two different pathways of activation, immunogenic and tolerogenic, induce different changes in the lipid composition of cultured CD11c+ cells, and highlights the important role of SWAP-70 in Cer dynamics in dendritic cells.
Cutting Edge: Distinct Regulatory Mechanisms Control Proinflammatory Cytokines IL-18 and IL-1β
Authors: Zhu Qifan , Kanneganti Thirumala-Devi 
Published: May 2017

Abstract
Interleukin-18 and IL-1β, which are cytokines of the IL-1 family, are synthesized as precursor proteins and activated by the inflammasome via proteolytic processing. IL-1β is only induced in response to inflammatory stimuli, but IL-18 is constitutively expressed. However, how IL-18 and IL-1β expression is regulated by different inflammatory signals remains poorly studied. In this study, we found that IL-18 and IL-1β are differentially regulated. Despite being constitutively expressed, IL-18 expression was increased and sustained after stimulation of TLRs. In contrast, IL-1β was induced but not sustained after chronic treatment. Furthermore, type I IFN signaling was essential for induction of IL-18 and macrophages lacking type I IFN signaling were impaired in their ability to promote IL-18 induction. Thus, our findings reveal a fundamental difference in IL-18 and IL-1β regulation and uncover novel mechanisms that are relevant to the inflammatory settings where these proinflammatory cytokines play a critical role.
A Real-analytic Nonpolynomially Convex Isotropic Torus with no Attached Discs
Authors: Gupta Purvi 
Published: May 2017

AbstractWe showbymeans of an example in that Gromov’s theoremon the presence of attached holomorphic discs for compact Lagrangianmanifolds is not true in the subcritical real-analytic case, even in the absence of an obvious obstruction, i.e., polynomial convexity.
Duodenal Trauma: Incidence and Management in Penetrating and Blunt Abdominal Trauma
Authors: Parra Michael W , Rosa Otto M , Filho Orlando C , Santin Stephanie , Fonseca Alexandre Z , Alvarez Bianca E , Ribeiro Jr Marcelo AF 
Published: May 2017

ABSTRACT
Rationale
Duodenal injuries are rare and most common due to penetrating abdominal trauma, especially gunshot wounds, with greatest prevalence among young men. Achieving simpler and more effective surgical procedures also contributes to the reduction of mortality and morbidity rates.

Objective
Review cases of penetrating and blunt duodenal trauma, the complexity of the injuries, incidence, management as well as morbidity and mortality.

Materials and methods
At Grajaú General Hospital, between January 2010 and May 2014, a retrospective analysis of 1,039 patients’ medical records who had undergone emergency exploratory laparotomies was done. From these cases, 298 were caused by blunt and penetrating abdominal traumas, and 11 suffered duodenal traumas.

Results
It was observed that there was a predominance of young adults (mean age 26.48 years) and all patients were males (100%), of which one injury was from blunt abdominal trauma, three from stab wounds, and seven caused by firearm. Most of the duodenal injuries were classified as grade II injuries and most commonly involved the fourth portion of the duodenum. We emphasize the association with injuries to other organs, especially the liver and the small intestine. In the cases we analyzed, we highlight the importance of time between entry of service and surgery in all patients being less than 6 hours. The most common surgery performed to repair these injuries was duodenorrhaphy (90.9%). In this series, there were four deaths. Postoperative complications included duodenal fistulae with spontaneous resolution.

Conclusion
Duodenal injuries are rare, and are most commonly due to penetrating abdominal trauma, especially gunshot wounds, with the greatest prevalence among young men. There is a need for early diagnosis and rapid surgical intervention, shortened and effective surgical procedures, due to the morbidity/mortality and high complexity of these injuries. This emphasizes the importance of early intervention in the short time before surgical procedure takes place.

How to cite this article
Ribeiro MAF Jr, Rosa OM, Filho OC, Santin S, Fonseca AZ, Alvarez BE, Parra MW. Duodenal Trauma: Incidence and Management in Penetrating and Blunt Abdominal Trauma. Panam J Trauma Crit Care Emerg Surg 2017;6(1):13-16.