bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Randomized, Single‐Center, Double‐Blind, Controlled Case Study Evaluating Procedure Pairing of a Neurocosmetic Postprocedure Cream With Radiofrequency Microneedling for Facial Rejuvenation
Authors: Maloney McKenzie E. , Iglesia Sofia , Kononov Tatiana , Zahr Alisar S. , Gold Michael H. 
Published: October 2024

ABSTRACTBackgroundRadiofrequency (RF) microneedling produces patient discomfort which deters patients from completing the recommended treatment series.ObjectiveThe primary objective was to determine the tolerability, safety, and efficacy of a neurocosmetic postprocedure cream post‐RF microneedling in reducing patient discomfort and enhancing recovery across the length of the study and, secondarily, to evaluate against a leading comparator. The third objective was to evaluate the efficacy of the neurocosmetic on self‐perceived improvement and objective grading.Materials and MethodsAn Institutional Review Board (IRB) approved, fourteen‐day, randomized, single‐center, double‐blind, controlled clinical case study was conducted with 11 healthy female subjects, 6 randomized to the neurocosmetic and 5 to the comparator cell. Following a 7‐day washout period, subjects received RF microneedling (face and neck) and applied the postprocedure cream twice daily for 7 days. Objective and subjective tolerability, self‐assessments, and clinical photography were performed immediately postprocedure, 24 h, three and seven days following the procedure.ResultsThe neurocosmetic was tolerable and safe. Erythema and stinging immediately decreased postprocedure, postneurocosmetic application. After 24 h, 83% favorably agreed the neurocosmetic “reduced irritation on the skin post‐procedure,” and after 7 days, 100% favorably agreed “experience with the product was positive and I would be interested in returning for a second treatment.” The neurocosmetic reduced skin tone redness in the face and neck faster and to a greater degree when measured against a comparator.ConclusionThe neurocosmetic postprocedure cream improved patient discomfort and enhanced recovery when used immediately post‐RF microneedling and after 7 days.IRB Protocol NumberPro00064211
The preventive health management self‐efficacy related to preterm labor scale in reproductive‐aged women: Validation of Turkish reliability and factor structure
Authors: Cirban‐Ekrem Ebru , Daşıkan Zeynep , Ünsal‐Atan Şenay 
Published: October 2024

AbstractAimThis study aims to test and adapt the Turkish psychometric properties of the preventive health management self‐efficacy related to premature labor (PHMSE‐PL) scale for women of reproductive age.MethodsThe study follows a methodological approach. The original scale comprises 34 items distributed across 5 subscales and is structured on a five‐point Likert scale. The study sample consisted of 351 women aged 19 to 49, all without any physical or mental disabilities, irrespective of marital status or pregnancy status. Exclusion criteria encompassed women engaged in healthcare professions such as medical faculty, nursing, or midwifery, as well as those with a history of preterm birth during pregnancy.ResultsDuring the validity assessment of the scale, language, content, and construct validity were scrutinized. In the reliability phase, internal consistency and stability over time ‐analyses were conducted. Following confirmation of language validity, all items achieved a content validity index value exceeding 0.80. Exploratory and confirmatory factor analyses were employed to assess structural validity, revealing that the scale retained its original grouping into five sub‐factors. These factors collectively accounted for 81.5% of the variance. The Cronbach's alpha coefficient for the entire scale reached 0.98, indicating high internal consistency. Test–retest analyses yielded a correlation coefficient of 0.99 between overall scale scores, demonstrating excellent consistency between the two measurement measurements.ConclusionsThe PHMSE‐PL scale adapted to Turkish culture demonstrated high levels of validity and reliability.
Influence of COVID‐19 on the clinical characteristics of patients with uterine cervical cancer in Japan: A single‐center retrospective study
Authors: Murakami Atsushi , Nomura Hidetaka , Abe Akiko , Fusegi Atsushi , Aoki Yoichi , Omi Makiko , Tanigawa Terumi , Okamoto Sanshiro , Yunokawa Mayu , Kanao Hiroyuki 
Published: October 2024

AbstractAimThis study investigated the impact of coronavirus disease 2019 (COVID‐19) on the clinical characteristics and interregional movement of patients with uterine cervical cancer.MethodsThis study included 1189 patients who underwent treatment for cervical cancer, including cervical intraepithelial neoplasm and adenocarcinoma in situ, at our hospital in Tokyo, Japan, in 2017–2018 and in 2021, before and after the pandemic, respectively. The patients' clinical information was compared during both periods. The clinical stage was unified using the International Federation of Gynecology and Obstetrics (FIGO) 2008 staging.ResultsThe number of patients treated for cervical cancer was 355, 420, and 414 in 2017, 2018, and 2021, respectively. The percentage of invasive carcinomas significantly increased from 158 (44.5%) and 196 (46.7%) to 219 (52.9%) (p = 0.049). In all periods, no significant differences were observed in median age, histological type, and treatment. The proportions of FIGO Stage IA1 were significantly elevated from 3.9% and 3.8% to 11.4% (p < 0.001). The percentage of patients from prefectures other than Tokyo significantly increased from 34.9% to 40.8% (p = 0.049). Furthermore, the proportion of patients with invasive carcinoma in private clinics increased from 28.0% to 37.9% (p = 0.014).ConclusionsThe number of patients with invasive carcinoma and the percentage of patients with invasive carcinoma referred from private clinics increased, indicating that the COVID‐19 pandemic influenced patients to delay consultations. Furthermore, the surge in patients from other prefectures indicates that medical resources were more limited in rural areas, another impact of COVID‐19.
Romosozumab versus denosumab in long‐term users of glucocorticoids: A pilot randomized controlled trial
Authors: Mok Chi Chiu , Chan Kar Li , Tse Sau Mei , Chen Sammy Pak Lam , Tan Kathryn Choon Beng , Ma Wai Han 
Published: October 2024

AbstractObjectiveTo compare the efficacy of romosozumab (ROMO) and denosumab (DEN) in prevalent long‐term glucocorticoid (GC) users.MethodsAdult patients receiving oral prednisolone (≥5 mg/day) with high risk of fracture were randomized to receive subcutaneous ROMO (210 mg monthly) or DEN (60 mg 6‐monthly) for 12 months, followed by DEN for two more doses. The primary end point was the change in spine bone mineral density (BMD) from Months 0 to 12. Secondary end points included changes in BMD of the spine/hip/femoral neck and bone turnover markers at various time points and adverse events.ResultsSeventy patients (age 62.6 ± 9.1 years; 96% women; median prednisolone dose 5.0 mg/day; duration of therapy 10.7 ± 7.4 years) were enrolled, and 63 completed the study. At Month 12, the spine BMD increased significantly in both ROMO (+7.3% ± 4.5%; p < 0.001) and DEN (+2.3% ± 3.1%; p < 0.001) groups. The absolute spine BMD gain from Months 0 to 12 was significantly greater in ROMO‐treated patients (p < 0.001). Although the total hip BMD at Month 12 also increased significantly in the ROMO (+1.6% ± 3.3%; p = 0.01) and DEN groups (+1.6% ± 2.6%; p = 0.003), the absolute BMD gain was not significantly different between the groups. At Month 24, the spine BMD continued to increase in both the ROMO (+9.7% ± 4.8%; p < 0.001) and DEN group (+3.0% ± 3.0%; p < 0.001) compared to baseline, and the absolute BMD gain remained significantly greater in ROMO‐treated patients. The total hip BMD continued to increase in both groups (ROMO +2.9% ± 3.7%; p < 0.001; DEN +2.2% ± 3.4%; p = 0.001), but the changes from baseline were similar. Injection site reaction was more frequently reported in ROMO‐treated patients.ConclusionROMO was superior to DEN in raising the spine BMD at Month 12 in chronic GC users. After switching to DEN, ROMO‐treated patients continued to gain spine BMD to a greater extent than DEN until Month 24.
Deep learning from head CT scans to predict elevated intracranial pressure
Authors: Sato Ryota , Akiyama Yukinori , Mikami Takeshi , Yamaoka Ayumu , Kamada Chie , Sakashita Kyoya , Takahashi Yasuhiro , Kimura Yusuke , Komatsu Katsuya , Mikuni Nobuhiro 
Published: October 2024

AbstractBackground and PurposeElevated intracranial pressure (ICP) resulting from severe head injury or stroke poses a risk of secondary brain injury that requires neurosurgical intervention. However, currently available noninvasive monitoring techniques for predicting ICP are not sufficiently advanced. We aimed to develop a minimally invasive ICP prediction model using simple CT images to prevent secondary brain injury caused by elevated ICP.MethodsWe used the following three methods to determine the presence or absence of elevated ICP using midbrain‐level CT images: (1) a deep learning model created using the Python (PY) programming language; (2) a model based on cistern narrowing and scaling of brainstem deformities and presence of hydrocephalus, analyzed using the statistical tool Prediction One (PO); and (3) identification of ICP by senior residents (SRs). We compared the accuracy of the validation and test data using fivefold cross‐validation and visualized or quantified the areas of interest in the models.ResultsThe accuracy of the validation data for the PY, PO, and SR methods was 83.68% (83.42%‐85.13%), 85.71% (73.81%‐88.10%), and 66.67% (55.96%‐72.62%), respectively. Significant differences in accuracy were observed between the PY and SR methods. Test data accuracy was 77.27% (70.45%‐77.2%), 84.09% (75.00%‐85.23%), and 61.36% (56.82%‐68.18%), respectively.ConclusionsOverall, the outcomes suggest that these newly developed models may be valuable tools for the rapid and accurate detection of elevated ICP in clinical practice. These models can easily be applied to other sites, as a single CT image at the midbrain level can provide a highly accurate diagnosis.
Adolescents' evaluations of peer and teacher unfair treatment in science, technology, engineering, and mathematics classes: Expected interventions
Authors: Mulvey Kelly Lynn , Cerda‐Smith Jacqueline , Herry Emily , Joy Angelina , Marlow Christina S. , Mathews Channing J. , Ozturk Emine 
Published: October 2024

AbstractThis study explores adolescents' evaluations of unfair teacher and peer behavior in science, technology, engineering, and mathematics (STEM) classes. Participants included ninth and tenth grade students from five public schools in the Southeastern United States, (N = 577, 45.9% female, 49% male, 5% other/prefer not to say/unsure). Students were ethnically representative of their communities: 48% White/European American, 22.7% Black/African American, 14% Latino/a/e/x, and 15.3% multi‐racial/other/prefer not to say. Measures assessed adolescents' responses to hypothetical scenarios of unfair treatment. The findings indicate that adolescents recognize both teacher and peer unfair behavior as wrong, with nuanced differences based on participants' gender and grade. Attribution analysis reveals varied expected reasons for unfair treatment. Responses to unfair behavior differ, with adolescents more likely to confront peers than teachers. Demographic factors, school climate, discrimination, belonging, and critical consciousness contribute to variations in judgments and responses. The study highlights the importance of addressing unfair treatment in STEM settings to foster inclusivity and support student persistence in STEM.
Reimagining LGBTIQ+ research – Acknowledging differences across subpopulations, methods, and countries
Authors: Hässler Tabea , Fogwell Nicole Theiss , Gonzalez Alejandra , Anderson Joel R. , Atwood S. 
Published: October 2024

AbstractInequalities and discrimination based on gender identity, sexual orientation, and sex characteristics remain pervasive worldwide. Scholars have collaborated to address structural and social barriers in LGBTIQ+ research, creating a substantial literature base. However, much of this work focuses on specific segments of the population, overlooks resilience‐ and strengths‐based approaches, and is predominantly conducted in the U.S. and other Western countries. In this introduction article, we discuss how this special issue extends previous research by uniting scholars globally to collaboratively reimagine the lens through which scientists conduct LGBTIQ+ research. By exploring diverging needs across subgroups of LGBTIQ+ people, discussing the (dis)advantages of various methodological choices, and offering a better understanding of how unique legal and social landscapes affect LGBTIQ+ individuals globally, this special issue aims to provide a comprehensive picture of the current state of research combined with concrete directions for redress. Given that barriers to conducting LGBTIQ+ research differ significantly by nation, we conclude this introductory article by calling for a research community that is more aware of unequal power dynamics within academia, willing to take action to reduce disparities in the global academic system, and inclusive of voices from underrepresented groups.
Impact of care coordination on service utilisation for children with medically complex cerebral palsy
Authors: Harvey Adrienne , Shepherd Daisy , Gibb Susan , Baikie Gordon , D'Aprano Anita , Reddihough Dinah , Babic Rose , Hunter Frances , Jealous Gretta , Imms Christine 
Published: October 2024

AimComplex care programmes for children with medically complex cerebral palsy (CP) exist; however, evidence for their impact is limited. This study (i) explored the impact of The Royal Children's Hospital Complex Care Hub (CCH) on hospital service utilisation rates over a 3‐year period for children with medically complex CP compared with those eligible but received routine care, and (ii) compared health, disability and socio‐demographic characteristics of children and their families in both groups.MethodsElectronic medical record data from 78 children (mean age 9.43 years, females n = 37) with medically complex CP who accessed CCH services, and 92 (mean age 10.86 years, females, n = 39) who received routine care were included. Multivariable regression was used to analyse service utilisation: number of emergency department (ED) presentations, length/number of inpatient and intensive care unit admissions and number/type of hospital appointments. Critical health‐care needs, functioning/disability profile and child/family demographics for each group were compared.ResultsMore children in the CCH group had a mixed motor type (73.1% vs. 15.2%), were classified within Gross Motor Function Classification System level V (76.9% vs. 34.8%), had respiratory, nutrition and social support needs and epilepsy. Children receiving CCH services had higher service utilisation rates; ED presentations (rate ratio (RR) = 1.81, 95% confidence interval (CI): 1.09–3.01), inpatient admissions (RR = 2.77, 95% CI: 2.01–3.83), outpatient encounters (RR = 1.69, 95% CI: 1.31–2.18) and telephone encounters (RR = 6.05, 95% CI: 4.56–8.02).ConclusionsChildren with medically complex CP accessing a complex care service have higher service utilisation rates yet have more complex clinical presentations and higher support needs.
An Overview of the Biological Functions and Mechanisms of Action of Medicinal Plants and Seaweeds in the Shrimp Culture
Authors: Pourmozaffar Sajjad , Reverter Miriam , Jahromi Saeid Tamadoni , Harikrishnan Ramasamy , Pazir Mohammad Khalil , Barzkar Noora , Mozanzadeh Mansour Torfi , Sarvi Behzad , Abolfathi Marzieh , Adeshina Ibrahim , Behzadi Siamak , Raji Abdullateef 
Published: October 2024

ABSTRACTDiseases are major constraints to developing large‐scale aquaculture practices in many countries. For decades, synthetic chemotherapeutic agents have been widely applied both as prophylactics and therapeutics to inhibit and control aquatic disease outbreaks. However, their use has become more restricted due to the negative impacts they have on the environment, the host and humans, as well as their limitations in preventing the emergence of antimicrobial‐resistant bacteria. Therefore, there is a growing interest in the use of medicinal plants and seaweeds as potential alternatives to antibiotics and other synthetic chemotherapeutics. Medicinal plants and seaweeds can enhance the immune systems of animals, thereby providing protection against numerous diseases while minimizing the adverse effects associated with synthetic chemotherapeutics. Furthermore, the advantages of medicinal plants and seaweeds, such as their effectiveness, easy availability and ability to be applied on a large scale, make them appealing for use in the aquaculture industry. The main goal of this study was to review the existing knowledge of the effects of medicinal plants and seaweeds, as well as their extracts, on shrimp growth, immune response and disease resistance against bacterial and viral agents. Moreover, this paper discusses the application of seaweeds in shrimp culture. We also conducted a literature review to identify gaps in the research and provide recommendations for further advancement in this field of study. Further studies should focus on evaluating other physiological aspects, such as feed and mineral utilization, enzyme activities and histological examination.
Species–soil relationships across Amazonia: Niche specificity and consistency in understorey ferns
Authors: Tuomisto Hanna , Suominen Lassi , Alonso Alfonso , Cárdenas Glenda , Lehtonen Samuli , Moulatlet Gabriel Massaine , Pérez Eneas , Sirén Anders , Weigelt Patrick , Zuquim Gabriela 
Published: October 2024

AbstractAimsKnowledge about species niches along environmental gradients is needed to understand community assembly and spatial variation in floristic composition and species richness. In Amazonian rainforests, such knowledge is largely lacking, although ferns have been used to infer overall floristic and edaphic patterns. Here we explore fern species distributions along an important edaphic gradient, how narrow their realised niches are and how sensitive inferences are to species commonness, data quality and the region being sampled.LocationAmazonia.MethodsWe used a large data set (1,215 transects across lowland Amazonia) to explore the realised niches of 54 species of two fern genera (Adiantum and Lindsaea) along a soil base cation concentration gradient. We used weighted averaging to estimate species optima and niche widths, and Huisman–Olff–Fresco modelling to assess species response shapes.ResultsOverall, species optima were rather evenly spread along the soil base cation concentration gradient, but Lindsaea optima were limited to the lower half of the gradient, whereas Adiantum optima were more often in the upper half. Most species had unimodal response curves. Mean niche width was ca. 25% of the observed gradient length for Adiantum and 17% for Lindsaea and was only weakly or not at all related to different aspects of species commonness. Species optima were robust to different modelling approaches and consistent across regional subsets. However, the central Amazonian data contained no transects with high soil base cation concentration, so species with high optima were either absent or obtained a lower optimum than in the NW and SW regions.ConclusionsOur results support niche‐related species sorting as an important process that defines species co‐occurrence, turnover and richness patterns within Amazonian rainforests. All Adiantum and Lindsaea species, including the most abundant ones, had narrow enough realised niches to be considered useful indicators of edaphic and floristic variation within the rainforest.
Pseudo‐green water as a potential enhancer of growth and coloration in European lobster, Homarus gammarus, larvae
Authors: Bell Matt E. , O'Grady Julie , Domech Paula C. , Frontaura Erik R. , Davies Simon J. , McCusker Stephen , Hinchcliffe James , Wan Alex H. L. 
Published: October 2024

AbstractDepleting European lobster, Homarus gammarus, wild stocks from historic overexploitation, stock enhancement programs, and farming of this lucrative species are viable options for meeting consumer demand. Early larval stages pose a hatchery challenge because of low survival rates. This study evaluates pseudo‐green water benefits during the larval stage. Commonly used aquaculture algal species, Tetraselmis suecica (TS), Dunaliella tertiolecta (DT), and Nannochloropsis sp. (N), were tested as a monoculture or mixture treatment over 13 days post‐hatching of the lobster larvae, from this, seven treatment permutations (TS, DT, N, TS + DT, TS + N, DT + N, and TS + DT + N) were included. A further eighth treatment with no added algae was used as a basal reference point (control). The growth assessment found that co‐culturing had benefited carapace length and shell coloration (cephalothorax, p = 0.023) but no enhancement to the weight or survival ratios was observed. All larvae reached stage III by the 13th day, with survival rates ranging between 12.5% and 20%. Results indicated that mixed algal species generally had higher mean growth perfromance values than monoalgal cultures and clearer water. Nannochloropsis sp. significantly improved growth performance (higher weight and length). Algal matrices containing Nannochloropsis sp. resulted in the highest growth performance, emphasizing the importance of co‐culturing lobster larvae with algae to improve hatchery operations.
(Mis)Alignment in resident and advisor co‐regulated learning in competency‐based training
Authors: Day Leora Branfield , Butler Deborah , Kuper Ayelet , Shah Rupal , Stroud Lynfa , Ginsburg Shiphra , Tavares Walter , Brydges Ryan 
Published: October 2024

AbstractBackground/ObjectiveIn implementing competence‐based medical education (CBME), some Canadian residency programmes recruit clinicians to function as Academic Advisors (AAs). AAs are expected to help monitor residents' progress, coach them longitudinally, and serve as sources of co‐regulated learning (Co‐RL) to support their developing self‐regulated learning (SRL) abilities. Implementing the AA role is optional, meaning each residency programme must decide whether and how to implement it, which could generate uncertainty and heterogeneity in how effectively AAs will “monitor and advise” residents. We sought to clarify how AA‐resident dyads collaboratively interpret assessment data from multiple sources, co‐create learning goals and action plans and attempt to enhance residents' SRL skills.MethodsShortly after each of their six meetings during two years of Internal Medicine residency, we conducted individual, brief interviews with AAs (N = 10) and residents (N = 10). We analysed transcripts using an abductive framework with theory‐based and evidence‐based sensitizing concepts.ResultsWe collected 49 residents and 36 AA ‘meeting debriefs’, which produced rich data on how dyads variably engaged in SRL and Co‐RL. Residents and AAs adopted “learning stances” that oriented their perceptions and approaches to Co‐RL. Their stances did not always align within dyads. We found unique patterns in how stances evolved or devolved over time, and in how these changes impacted dyads' Co‐RL processes. While some dyads evolved to engage in proactive co‐regulation, most stayed consistent or oscillated reactively in their relationships, with little apparent Co‐RL focused on helping residents to develop clinical competencies through SRL. We catalogued multiple influential sources of regulation of learning.ConclusionThe conceptually ideal form of Co‐RL was not consistently achieved in this well‐intended implementation of AA‐resident dyads. To better translate ‘coaching over time’ from intention to practice, we recommend that residency programmes use Co‐RL principles to refine CBME processes, including refining assessment tools, resident orientation sessions and faculty development practices.