bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical features of Guillain-Barré syndrome and chronic inflammatory demyelinating polyradiculoneuritis associated with SLE
Authors: Wang Jingqiao , Zhang Zhe , Qian Junyan , Zhang Shangzhu , Qiao Lin , Li Mengtao , Zhao Yan , Zeng Xiaofeng 
Published: October 2024

ObjectiveWe report on the clinical characteristics, treatments and outcomes of Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuritis (CIDP) associated with SLE.MethodsPatients treated at Peking Union Medical College Hospital between January 2004 and November 2021 who fulfilled the diagnostic criteria for SLE and GBS/CIDP (n=9) were included. Clinical presentations, lab results, treatment regimens and prognoses were retrieved and analysed.ResultsSix patients were diagnosed with SLE and GBS, while three were diagnosed with SLE and CIDP, with the average age at diagnosis of 38.6±18.2 years. SLE disease duration ranges from 1 week to 36 years, and the courses of GBS and CIDP range from 1 week to 2 months and from 2 months to 15 months, respectively. All patients exhibited either or both limb paresthesia and weakness, other neurological symptoms include dysphagia, peripheral facial nerve palsy and respiratory and cardiac arrest. The median cerebral spinal fluid white blood cell count and protein level were 0.002×109/L (0–0.006×109/L) and 0.79 g/L (0.57–7.09 g/L), respectively. All patients received glucocorticoid and immunoglobulin therapy. Seven patients received cyclophosphamide, and seven patients received intrathecal injections of methotrexate and dexamethasone. Two patients had complete resolution, five experienced marked improvements and two failed to improve with treatments.ConclusionSLE-associated GBS/CIDP may manifest regardless of disease systemic activity. Clinical features may differ from that of pure GBS/CIDP, and treatment often requires immunosuppressants, making differential diagnosis crucial, especially for patients with GBS/CIDP presenting as the first manifestation of SLE.
Identities with b-generalized derivations and generalized skew derivations on prime rings
Authors: Singh Lovepreet , De Filippis Vincenzo , Tiwari S. K. 
Published: October 2024

Let [Formula: see text] be a prime ring of characteristic different from [Formula: see text], [Formula: see text] be the right Martindale quotient ring of [Formula: see text], [Formula: see text] the extended centroid of [Formula: see text], [Formula: see text] be a noncentral Lie ideal of [Formula: see text], [Formula: see text] and [Formula: see text] be two nonzero [Formula: see text]-generalized derivations of [Formula: see text]. Suppose there exist fixed integers [Formula: see text] such that [Formula: see text], for all [Formula: see text], then either [Formula: see text] satisfies the standard identity [Formula: see text] or there is [Formula: see text] such that [Formula: see text], [Formula: see text], for any [Formula: see text], and one of the following holds: (a) there exists [Formula: see text], (b) [Formula: see text] and [Formula: see text] are [Formula: see text]-linearly dependent. Then, in the second part of the paper we prove a similar result in the case [Formula: see text] and [Formula: see text] are generalized skew derivations of [Formula: see text] such that [Formula: see text], for all [Formula: see text].
SpatialDeX Is a Reference-Free Method for Cell-Type Deconvolution of Spatial Transcriptomics Data in Solid Tumors
Authors: Liu Xinyi , Tang Gongyu , Chen Yuhao , Li Yuanxiang , Li Hua , Wang Xiaowei 
Published: October 2024

Abstract
The rapid development of spatial transcriptomics (ST) technologies has enabled transcriptome-wide profiling of gene expression in tissue sections. Despite the emergence of single-cell resolution platforms, most ST sequencing studies still operate at a multicell resolution. Consequently, deconvolution of cell identities within the spatial spots has become imperative for characterizing cell-type–specific spatial organization. To this end, we developed Spatial Deconvolution Explorer (SpatialDeX), a regression model–based method for estimating cell-type proportions in tumor ST spots. SpatialDeX exhibited comparable performance to reference-based methods and outperformed other reference-free methods with simulated ST data. Using experimental ST data, SpatialDeX demonstrated superior performance compared with both reference-based and reference-free approaches. Additionally, a pan-cancer clustering analysis on tumor spots identified by SpatialDeX unveiled distinct tumor progression mechanisms both within and across diverse cancer types. Overall, SpatialDeX is a valuable tool for unraveling the spatial cellular organization of tissues from ST data without requiring single-cell RNA-seq references.
Significance: The development of a reference-free method for deconvolving the identity of cells in spatial transcriptomics datasets enables exploration of tumor architecture to gain deeper insights into the dynamics of the tumor microenvironment.
Association between Immune-Related Adverse Events and Atezolizumab in Previously Treated Patients with Unresectable Advanced or Recurrent Non–Small Cell Lung Cancer
Authors: Hayashi Hidetoshi , Nishio Makoto , Akamatsu Hiroaki , Goto Yasushi , Miura Satoru , Gemma Akihiko , Yoshino Ichiro , Misumi Toshihiro , Kijima Takashi , Takase Naoto , Fujita Masaki , Tasaka Sadatomo , Mouri Atsuto , Kondo Tetsuro , Takamura Kei , Kawashima Yosuke , Imaizumi Kazuyoshi , Iwasawa Shunichiro , Nakagawa Shintaro , Mitsudomi Tetsuya 
Published: October 2024

Abstract

Purpose:
Real-world, large-scale studies on the association between immune-related adverse events (irAE) and immune checkpoint inhibitor therapy effectiveness are limited. We evaluated overall survival (OS) and progression-free survival based on the occurrence and grade of irAEs.

Patients and Methods:
We used data from Japanese patients with unresectable advanced or recurrent non–small cell lung cancer (NSCLC) who received atezolizumab and were enrolled in J-TAIL, a multicenter, prospective, single-arm observational study.

Results:
Among the 1,002 patients, 190 (19.0%) developed irAEs. The most common irAEs were skin disorders (3.8%) of any grade and interstitial lung disease (1.5%) of grade ≥3. Patients who developed irAEs within 4 or 6 weeks of treatment initiation had higher baseline C-reactive protein levels than those without irAEs. OS was longer in patients with irAEs [HR, 0.66; 95% confidence interval (CI), 0.54–0.82], particularly in those with low-grade irAEs (HR, 0.45; 95% CI, 0.33–0.62), than in patients without irAEs. The HR (95% CI) for OS in patients with low-grade and high-grade skin or endocrine disorder–related irAEs was 0.42 (0.28–0.64) and 0.37 (0.15–0.88), respectively. The HR (95% CI) for OS in patients with low-grade and high-grade irAEs other than skin or endocrine disorders was 0.44 (0.30–0.65) and 1.27 (0.96–1.69), respectively.

Conclusions:
In patients with unresectable advanced or recurrent NSCLC treated with atezolizumab in real-world settings, irAEs are associated with a clinical benefit except in those with high-grade irAEs other than skin and endocrine disorders.

Significance:
Immune checkpoint inhibitors are useful for treating NSCLC but can cause life-threatening irAEs. This study had a large sample size and stratified the analysis by irAE type and grade. The results suggest that improved management of irAEs may improve the therapeutic effect of atezolizumab.
Genomic Features of Newly Diagnosed Large B-cell Lymphoma with or without Subsequent Disease Progression
Authors: Landsburg Daniel J. , Morrissette Jennifer J.D. , Nasta Sunita D. , Barta Stefan K. , Schuster Stephen J. , Chong Elise A. , Svoboda Jakub , Barlev Ashley , Bagg Adam , Priore Salvatore F. 
Published: October 2024

Abstract
Genomic analysis has the potential to both risk-stratify and inform management of patients diagnosed with large B-cell lymphomas (LBCL). We analyzed cases of patients with newly diagnosed LBCL treated with standard immunochemotherapy from three publicly available cohorts of patients on which FISH and next-generation sequencing were performed to determine the frequency of genomic alterations based upon the development of disease progression. Cases from 698 patients were analyzed, with 201 experiencing disease progression and 497 experiencing no disease progression by 24 months after diagnosis. When analyzing for the presence of MYC rearrangement and MYC–BCL2 dual-rearrangement/double-hit status, as well as variants predicted to result in alterations in protein function in 15 genes common to next-generation sequencing panels from all three cohorts, only MYC rearrangement and TP53 mutation were associated with significantly higher odds of disease progression on multivariate analysis. Additionally, cases from patients who experienced disease progression demonstrated a high frequency of specific genomic alterations when analyzed by cohort or cell-of-origin classification by IHC when available. Individual genomic features of LBCL cases may predict for the development of disease progression in newly diagnosed patients treated with standard therapies, as well as occur at higher frequencies in cases of disease progression based upon geographic region and/or cell-of-origin status. These novel findings support efforts to evaluate genomic features as biomarkers for response to specific therapies in subsets of patients with LBCL who experience disease progression, which may lead to discovery of more effective treatment options.

Significance:
Genomic features of LBCL that can be detected by clinical laboratory assays may predict for resistance to first-line immunochemotherapy, as well as support the exploration of genomic features as biomarkers of response to therapies which could be offered to patients who experience disease progression.
Performance of a Protein Language Model for Variant Annotation in Cardiac Disease
Authors: Hochstadt Aviram , Barbhaiya Chirag , Aizer Anthony , Bernstein Scott , Cerrone Marina , Garber Leonid , Holmes Douglas , Knotts Robert J. , Kushnir Alex , Martin Jacob , Park David , Spinelli Michael , Yang Felix , Chinitz Larry A. , Jankelson Lior 
Published: October 2024

Background
Genetic testing is a cornerstone in the assessment of many cardiac diseases. However, variants are frequently classified as variants of unknown significance, limiting the utility of testing. Recently, the DeepMind group (Google) developed AlphaMissense, a unique artificial intelligence–based model, based on language model principles, for the prediction of missense variant pathogenicity. We aimed to report on the performance of AlphaMissense, accessed by VarCardio, an open web‐based variant annotation engine, in a real‐world cardiovascular genetics center.

Methods and Results

All genetic variants from an inherited arrhythmia program were examined using AlphaMissense via VarCard.io and compared with the ClinVar variant classification system, as well as another variant classification platform (Franklin by Genoox). The mutation reclassification rate and genotype–phenotype concordance were examined for all variants in the study. We included 266 patients with heritable cardiac diseases, harboring 339 missense variants. Of those, 230 (67.8%) were classified by ClinVar as either variants of unknown significance or nonclassified. Using VarCard.io, 198 variants of unknown significance (86.1%, 95% CI, 80.9–90.3) were reclassified to either likely pathogenic or likely benign. The reclassification rate was significantly higher for VarCard.io than for Franklin (86.1% versus 34.8%,
P
<0.001). Genotype–phenotype concordance was highly aligned using VarCard.io predictions, at 95.9% (95% CI, 92.8–97.9) concordance rate. For 109 variants classified as pathogenic, likely pathogenic, benign, or likely benign by ClinVar, concordance with VarCard.io was high (90.5%).

Conclusions
AlphaMissense, accessed via VarCard.io, may be a highly efficient tool for cardiac genetic variant interpretation. The engine's notable performance in assessing variants that are classified as variants of unknown significance in ClinVar demonstrates its potential to enhance cardiac genetic testing.
The “Negotiation in the News” Assignment: Building Negotiation Competencies Using Real-World Analysis
Authors: Weirup Amanda , Manwaring Melissa 
Published: October 2024

Abstract
The “Negotiation in the News” (NITN) assignment is designed to enhance student negotiation skills through analysis of real-world negotiations and, in doing so, to address specific pedagogical limitations of traditional role plays and case studies. In the NITN assignment, which takes place over several weeks or months, student groups select, monitor, and analyze ongoing negotiations reported in the media. Through this process, students learn to recognize organic real-world negotiations, proactively gather and interpret relevant data, analyze dynamic negotiation processes as they unfold in real time, and assess the impact of complex contextual factors. We describe the design and implementation of the NITN assignment, illustrate examples from student projects, and present assessment data demonstrating its effectiveness in improving negotiation competencies.
The Anatomy of Iconicity: Cumulative Structural Analogies Underlie Objective and Subjective Measures of Iconicity
Authors: Punselie Stella , McLean Bonnie , Dingemanse Mark 
Published: October 2024

Abstract
The vocabularies of natural languages harbour many instances of iconicity, where words show a perceived resemblance between aspects of form and meaning. An open challenge in this domain is how to reconcile different operationalizations of iconicity and link them to an empirically grounded theory. Here we combine three ways of looking at iconicity using a set of 239 iconic words from 5 spoken languages (Japanese, Korean, Semai, Siwu and Ewe). Data on guessing accuracy serves as a baseline measure of probable iconicity and provides variation that we seek to explain and predict using structure-mapping theory and iconicity ratings. We systematically trace a range of cross-linguistically attested form-meaning correspondences in the dataset, yielding a word-level measure of cumulative iconicity that we find to be highly predictive of guessing accuracy. In a rating study, we collect iconicity judgments for all words from 78 participants. The ratings are well-predicted by our measure of cumulative iconicity and also correlate strongly with guessing accuracy, showing that rating tasks offer a scalable method to measure iconicity. Triangulating the measures reveals how structure-mapping can help open the black box of experimental measures of iconicity. While none of the methods is perfect, taken together they provide a well-rounded way to approach the meaning and measurement of iconicity in natural language vocabulary.
On the aquatic phenology of sympatric crested and marbled newts (genus Triturus)
Authors: Arntzen Jan W. 
Published: October 2024

Abstract
The large-bodied newts Triturus cristatus and T. marmoratus possess ranges that overlap in western France where they frequently share breeding ponds. I test the hypothesis that the aquatic phenology differs between them, as associated with a more aquatic and terrestrial life style respectively. Total adult population sizes were determined in spring in 13 experiments by the capture-mark-recapture methodology, followed by equivalent experiments in summer. Population sizes dropped by an order of magnitude on average whereas species frequencies changed in favour of T. cristatus, suggesting that T. marmoratus leaves the breeding site earlier than T. cristatus. Interspecies hybrids behaved like T. marmoratus. Descriptions are provided of other features (in ecology, morphology, demography, and colouration pattern) that support the different, aquatic versus terrestrial life styles of T. cristatus and T. marmoratus.
Mediated Immediacy and the Distinct Theological Contribution of Christian Experiences of God
Authors: Andersen John Daniel 
Published: October 2024

Abstract
The purpose of this article is to contribute with some analytical philosophical perspectives to Pentecostal theology and the contemporary understanding of Pentecostal experiences of God as ‘mediated immediacy’ to further specify these experiences’ distinct contribution to systematic theology. A trend within Pentecostal theology is to emphasize how Pentecostal experiences are encounters that are theologically interpreted and related to specific beliefs. However, the amount of information and areas of theological knowledge from such experiences need more clarifications. Hence, in Part 1, the author presents four philosophical arguments why experiences of God can contribute to systematic theology with prima facie justified beliefs or theological knowledge. In Part 2, the author proposes that their distinct theological contribution can be specified as manifestation beliefs about God’s doing and being towards a person that represent personal and relational knowledge of God.
Plato’s Charmides and the Project of the Science of All Sciences
Authors: Zingano Marco 
Published: October 2024

Abstract
The purpose of this paper is to re-evaluate the position and role of Plato’s Charmides by analysing its second part. In this section, Critias tries to explain sôphrosunê as a form of knowledge that is self-referential in the sense that it is a type of knowledge of all other forms of knowledge without being knowledge of the objects of those other forms. Plato remains doubtful about the feasibility and usefulness of such a concept, as he believes that all types of knowledge must be about something else, separate from the forms of knowledge themselves. He also thinks that such formal knowledge, if it indeed exists, is of little interest. This paper also aims to demonstrate that the Charmides belongs to a group of dialogues in which Plato discusses other people’s proposals, similar to what happens in the Theaetetus. In the case of the Charmides, this is very likely the project that we will later see developed in Aristotle’s Posterior Analytics.
Trends in U.S. Atlantic Tropical Cyclone Damage, 1900–2022
Authors: Willoughby H. E. , Hernandez J. I. , Pinnock Andrew 
Published: October 2024

Abstract
A series of papers published since 1998 assert that U.S. tropical cyclone (TC) damage, when “normalized” for individual wealth, population, and inflation, exhibits no increase attributable to anthropogenic global warming (AGW). This result is here questioned for three reasons: 1) The then-year (no demographic or economic adjustments) U.S. TC damage increases 2.5% yr−1 faster than U.S. then-year gross domestic product. This result, which is substantially due to the faster growth of assets in hurricane-prone states, shows that TC impacts on the total U.S. economy double every generation. 2) Fitting of an exponential curve to normalized damage binned by 5-yr “pentads” yields a growth rate of 1.06% yr−1 since 1900, although causes besides AGW may contribute. 3) During the twenty-first century, when the Atlantic multidecadal oscillation (AMO) was in its warm phase, the most damaging U.S. TCs struck at twice the rate of the warm AMO of the twentieth century and 4 times the rate of the entire twentieth century, both warm and cool AMO phases. A key unanswered question is as follows: What will happen when (and if) the AMO returns to its cool phase later in this century?

Significance Statement
U.S. hurricane damage, normalized for changes in inflation, population, and wealth, increases by approximately 1% yr−1. For 1900–2022, 1% yr−1 is equivalent to a factor of >3 increase, substantially but not entirely, attributable to climate change. The incidence of the most damaging tropical cyclones (TCs) approximately doubled in the twenty-first century compared with climatologically analogous periods of the twentieth century. These results contradict the previously published work that introduced normalization and found zero trend in normalized damage but are consistent with physical reasoning and modeling studies.
Online Mental Health Assessment in a psychiatry emergency department in adults using touchscreen mobile devices: A randomised controlled trial
Authors: Fernando Irosh , Hinwood Madeleine , Carey Mariko , Gupta Rahul , Conrad Agatha , Heard Todd , Lampe Lisa 
Published: October 2024

Objective: To determine whether completion of an online mental health self-assessment by patients who are waiting in the emergency department can save clinician time taken to complete clinical assessment and documentation. Methods: Patients presenting to a psychiatric emergency department for a period of 6 months were allocated by week of presentation to either the intervention arm (online mental health self-assessment, followed by a clinical interview) or the control arm (usual assessment) arm on a random basis. Time at the beginning and end of the interview was recorded and used to derive interview time. Similarly, time at the beginning and end of the clinical documentation was recorded and used to derive the time to complete clinical documentation. Results: Of 168 patients who presented during the study period, 69 (38.55%) agreed to participate, 33 completed the usual assessment and 30 completed the online mental health self-assessment followed by a clinical interview. Patients receiving usual care had a statistically significant, t(61) = 2.15, p = 0.035, longer interview duration (M = 48.7 minutes, SD = 19.8) compared with those in the online mental health self-assessment arm (M = 38.9 minutes, SD = 15.9). There was no statistically significant difference between groups for documentation time, t(61) = −0.64, p = 0.52. Conclusion: Online mental health self-assessment was associated with a statistically significant reduction in interview time by approximately 10 minutes without increasing documentation time. While online mental health self-assessment is not appropriate for all patients in the emergency department setting, it is likely to yield greater benefits in less acute settings.
An Empirical Analysis of Sectoral Export Demand Elasticities and Trade Policies: The Case of India
Authors: Wijeweera Albert , Reppas Dimitrios 
Published: October 2024

This article contributes to the existing literature on India’s exports by estimating price and income elasticities for different export categories. The objective is to identify potential policy implications associated with sectoral export elasticities. The analysis focuses on five categories of exports: (a) goods and services exports, (b) goods exports, (c) services exports, (d) food exports and (e) merchandise exports. Annual data spanning the period 1994–2021 is used for the analysis, and the bound testing cointegration approach based on the Auto-Regressive Distributed Lag (ARDL) method is employed to estimate export elasticities for each category. The study finds that sectoral price elasticities of exports are inelastic and small in magnitude, suggesting that although a currency depreciation would lead to an increase in demand for its exports, it is not expected to have a positive impact on the aggregate export earnings of India. Income elasticities, however, are positive and large in magnitude, implying that India’s export performance is significantly responsive to changes in global income levels. Hence, an understanding of income export elasticity in different sectors provides valuable insights for policymakers to tailor strategies in an evolving global economic landscape. JEL Codes: C22, F13, F32, F43