bluuebunny/crossref_metadata_2025_split huggingface dataset:
Creating business value through corporate communication
Authors: Zerfass Ansgar , Viertmann Christine 
Published: January 2017

Purpose
The purpose of this paper is to report on a multi-step research project which explores concepts that explain communication value across different disciplines and builds a framework that identifies and systematizes communication goals linked to generic corporate goals.

Design/methodology/approach
Based on a literature review of work on value creation through communication, drawn from 815 publications in 36 international journals across several disciplines (public relations, marketing, management, etc.) and published from the year 2000 onward, the authors have developed a framework, named “Communication Value Circle.” The application of the framework was discussed with chief communication officers from global companies and was used during a communication alignment process in a global healthcare company.

Findings
Empirical surveys across several continents show that communication professionals use a multitude of rationales to explain the value of their work to top executives. These range from building reputation, brands and identity, to gaining thought leadership, boosting sales, motivating employees, preventing crises and listening to stakeholders. The researchers have identified four major value dimensions of communication (enabling operations, building intangibles, adjusting strategy, and ensuring flexibility). The framework encompasses 12 specific goals for communication that can be derived from corporate strategy.

Research limitations/implications
The framework stimulates the debate on the diverse concepts of communication value, performance and measurement, and the need to integrate those approaches into theory and practice. Additional qualitative studies to verify the framework are proposed.

Practical implications
The communication value circle can be used as a management tool for planning, evaluating, and revising strategic directions for communication in any corporation.

Originality/value
Explaining the value of communication continues to be one of the most important challenges for professionals and scholars alike. This paper proposes a consistent explanation for the theory and practice of what constitutes corporate communication.
Effect of parthanatos on ropivacaine‐induced damage in SH‐SY5Y cells
Authors: Zheng Ting , Zheng Chun‐ying , Zheng Xiao‐chun , Zhao Ruo‐guang , Chen Yan‐qing 
Published: January 2017

SummaryRopivacaine is one of the most common but toxic local anaesthetics, and the mechanisms underlying its neurotoxicity are still largely unknown. This study was conducted to prepare a ropivacaine‐induced neuronal injury model and research the effects of ropivacaine on PARP‐1 activation and nicotinamide adenine dinucleotide (NAD)+ depletion. The cell death and apoptosis of ropivacaine‐induced SH‐SY5Y cells were detected with flow cytometry. The lactate dehydrogenase cycling reaction measured the NAD+ level, and western blots were used to analyze the expression levels of PARP‐1 and apoptosis‐inducing factor (AIF) after ropivacaine treatments with different concentrations and durations. A PARP‐1 inhibitor (PJ‐34) was used to confirm the relationship between PARP‐1 activation and NAD+ depletion. Hoechst 33258 nuclear staining and a mitochondrial membrane potential (Δψm) assay were used to detect the role of exogenous NAD+ in ropivacaine‐induced neuronal injury. Ropivacaine‐induced SH‐SY5Y cell death and apoptosis, PARP‐1 activation, and AIF increase as well as intracellular NAD+ depletion occurred in a time‐ and concentration‐dependent manner (P<.05). PARP‐1 activation led to NAD+ depletion (P<.05). Exogenous NAD+ impaired ropivacaine‐induced nuclear injury (P<.05). Ropivacaine treatment induced PARP‐1 activation and NAD+ depletion (P<.05). Parthanatos (PARP‐1‐dependent cell death) was definitely involved in ropivacaine‐induced neuronal injury, and exogenous NAD+ may be a novel therapeutic method for parthanatos‐dependent neuronal injury.
Electoral rules, corruption, inequality and evaluations of democracy
Authors: DONOVAN TODD , KARP JEFFREY 
Published: January 2017

AbstractFeatures of electoral systems have been found to have positive effects on evaluations of democracy. This article proposes that there are larger social forces that must be accounted for in such analyses. Using European Social Survey measures of democratic expectations and the ‘satisfaction with democracy’ item, this study tests for effects of electoral rules on perceptions of democracy. It is found that multipartyism/proportionality and preferential ballot structure appear to correspond with positive evaluations of elections and parties, and with greater satisfaction with how democracy is functioning. However, these relationships dissipate when corruption and income inequality are accounted for. This suggests substantial limits to the capacity of electoral reforms to enhance democratic legitimacy. It also suggests that studies of mass perceptions of democratic performance may over‐estimate effects of electoral rules if country‐level corruption and income inequality are not accounted for.
Health Services Utilization in Older Adults with Dementia Receiving Care Coordination: The MIND at Home Trial
Authors: Amjad Halima , Wong Stephanie K. , Roth David L. , Huang Jin , Willink Amber , Black Betty S. , Johnston Deirdre , Rabins Peter V. , Gitlin Laura N. , Lyketsos Constantine G. , Samus Quincy M. 
Published: January 2017

ObjectiveTo investigate effects of a novel dementia care coordination program on health services utilization.Data Sources/Study SettingA total of 303 community‐dwelling adults aged ≥70 with a cognitive disorder in Baltimore, Maryland (2008–2011).Study DesignSingle‐blind RCT evaluating efficacy of an 18‐month care coordination intervention delivered through community‐based nonclinical care coordinators, supported by an interdisciplinary clinical team.Data Collection/Extraction MethodsStudy partners reported acute care/inpatient, outpatient, and home‐ and community‐based service utilization at baseline, 9, and 18 months.Principal FindingsFrom baseline to 18 months, there were no significant group differences in acute care/inpatient or total outpatient services use, although intervention participants had significantly increased outpatient dementia/mental health visits from 9 to 18 months (p = .04) relative to controls. Home and community‐based support service use significantly increased from baseline to 18 months in the intervention compared to control (p = .005).ConclusionsWhile this dementia care coordination program did not impact acute care/inpatient services utilization, it increased use of dementia‐related outpatient medical care and nonmedical supportive community services, a combination that may have helped participants remain at home longer. Future care model modifications that emphasize delirium, falls prevention, and behavior management may be needed to influence inpatient service use.
Sheep Milk: Physicochemical Characteristics and Relevance for Functional Food Development
Authors: Balthazar C.F. , Pimentel T.C. , Ferrão L.L. , Almada C.N. , Santillo A. , Albenzio M. , Mollakhalili N. , Mortazavian A.M. , Nascimento J.S. , Silva M.C. , Freitas M.Q. , Sant’Ana A.S. , Granato D. , Cruz A.G. 
Published: January 2017

AbstractSheep milk has a high nutritional value and high concentrations of proteins, fats, minerals, and vitamins, as compared to the milks of other domestic species. The physicochemical and nutritional characteristics of sheep milk can be advantageous for the manufacture of products containing prebiotic ingredients and/or probiotic bacteria, which are major categories in the functional food market. Following this technological trend, this review will address the characteristics and advantages of sheep milk as a potentially functional food, as well as the development of sheep milk dairy products containing prebiotics and/or probiotics.
Good Governance in the Bioeconomy
Authors: Devaney Laura , Henchion Maeve , Regan Áine 
Published: January 2017

SummaryIn response to growing societal and environmental challenges, the concept of the bioeconomy has emerged in Europe, shifting society away from fossil fuels to utilising renewable biological resources to meet food, feed, fuel and material needs. The bioeconomy poses unique questions for governing stakeholders, with a need to simultaneously consider issues of food, fuel and resource security, competition for biomass supply, environmental degradation, climate change, economic growth and rural development. It thus represents one of the most politically complex areas facing agri‐food and rural resource sectors internationally. Further development of the bioeconomy and its impact on society will depend on how it is governed. It is widely accepted that good governance will require input from a diverse range of stakeholders beyond traditional government intervention. In this article, we explore the application of good governance principles as a common set of objectives for European stakeholders to strive towards, with particular consideration given to the principles of accountability and participation. How these elements need to be addressed as a priority for the economic, environmental and social sustainability of the future European bioeconomy is highlighted.
Yeast's balancing act between ethanol and glycerol production in low‐alcohol wines
Authors: Goold Hugh D. , Kroukamp Heinrich , Williams Thomas C. , Paulsen Ian T. , Varela Cristian , Pretorius Isak S. 
Published: January 2017

SummaryAlcohol is fundamental to the character of wine, yet too much can put a wine off‐balance. A wine is regarded to be well balanced if its alcoholic strength, acidity, sweetness, fruitiness and tannin structure complement each other so that no single component dominates on the palate. Balancing a wine's positive fruit flavours with the optimal absolute and relative concentration of alcohol can be surprisingly difficult. Over the past three decades, consumers have increasingly demanded wine with richer and riper fruit flavour profiles. In response, grape and wine producers have extended harvest times to increase grape maturity and enhance the degree of fruit flavours and colour intensity. However, a higher degree of grape maturity results in increased grape sugar concentration, which in turn results in wines with elevated alcohol concentration. On average, the alcohol strength of red wines from many warm wine‐producing regions globally rose by about 2% (v/v) during this period. Notwithstanding that many of these ‘full‐bodied, fruit‐forward’ wines are well balanced and sought after, there is also a significant consumer market segment that seeks lighter styles with less ethanol‐derived ‘hotness’ on the palate. Consumer‐focussed wine producers are developing and implementing several strategies in the vineyard and winery to reduce the alcohol concentration in wines produced from well‐ripened grapes. In this context, Saccharomyces cerevisiae wine yeasts have proven to be a pivotal strategy to reduce ethanol formation during the fermentation of grape musts with high sugar content (> 240 g l−1). One of the approaches has been to develop ‘low‐alcohol’ yeast strains which work by redirecting their carbon metabolism away from ethanol production to other metabolites, such as glycerol. This article reviews the current challenges of producing glycerol at the expense of ethanol. It also casts new light on yeast strain development programmes which, bolstered by synthetic genomics, could potentially overcome these challenges.
Whole genome sequencing analysis of lung adenocarcinoma in Xuanwei, China
Authors: Wang Xiao , Li Jing , Duan Yong , Wu Huifei , Xu Qiuyue , Zhang Yanliang 
Published: January 2017

BackgroundThe lung cancer mortality rate in Xuanwei city is among the highest in China and adenocarcinoma is the major histological type. Lung cancer has been associated with exposure to indoor smoky coal emissions that contain high levels of polycyclic aromatic hydrocarbons; however, the pathogenesis of lung cancer has not yet been fully elucidated.MethodsWe performed whole genome sequencing with lung adenocarcinoma and corresponding non‐tumor tissue to explore the genomic features of Xuanwei lung cancer. We used the Molecule Annotation System to determine and plot alterations in genes and signaling pathways.ResultsA total of 3 428 060 and 3 416 989 single nucleotide variants were detected in tumor and normal genomes, respectively. After comparison of these two genomes, 977 high‐confidence somatic single nucleotide variants were identified. We observed a remarkably high proportion of C·G‐A·T transversions. HECTD4, RCBTB2, KLF15, and CACNA1C may be cancer‐related genes. Nine copy number variations increased in chromosome 5 and one in chromosome 7. The novel junctions were detected via clustered discordant paired ends and 1955 structural variants were discovered. Among these, we found 44 novel chromosome structural variations. In addition, EGFR and CACNA1C in the mitogen‐activated protein kinase signaling pathway were mutated or amplified in lung adenocarcinoma tumor tissue.ConclusionWe obtained a comprehensive view of somatic alterations of Xuanwei lung adenocarcinoma. These findings provide insight into the genomic landscape in order to further learn about the progress and development of Xuanwei lung adenocarcinoma.
Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology
Authors: Sharma Vinod K. , Hill Shirley Y. 
Published: January 2017

BackgroundOffspring with a family history of alcohol dependence (AD) have been shown to have altered structural and functional integrity of corticolimbic brain structures. Similarly, prenatal exposure to alcohol is associated with a variety of structural and functional brain changes. The goal of this study was to differentiate the brain gray matter volumetric differences associated with familial risk and prenatal exposure to alcohol among offspring while controlling for lifetime personal exposures to alcohol and drugs.MethodsA total of 52 high‐risk (HR) offspring from maternal multiplex families with a high proportion of AD were studied along with 55 low‐risk (LR) offspring. Voxel‐based morphometric analysis was performed using statistical parametric mapping (SPM8) software using 3T structural images from these offspring to identify gray matter volume differences associated with familial risk and prenatal exposure.ResultsSignificant familial risk group differences were seen with HR males showing reduced volume of the left inferior temporal, left fusiform, and left and right insula regions relative to LR males, controlling for prenatal exposure to alcohol drugs and cigarettes. HR females showed a reduction in the right fusiform but also showed a reduction in volume in portions of the cerebellum (left crus I and left lobe 8). Prenatal alcohol exposure effects, assessed within the familial HR group, was associated with reduced right middle cingulum and left middle temporal volume. Even low exposure resulting from mothers drinking in amounts less than the median of those who drank (53 drinks or less over the course of the pregnancy) showed a reduction in volume in the right anterior cingulum and in the left cerebellum (lobes 4 and 5).ConclusionsFamilial risk for AD and prenatal exposure to alcohol and other drugs show independent effects on brain morphology.
Ethanol Induces Platelet Apoptosis
Authors: Liu Lei , Chen Mengxing , Zhao Lili , Zhao Qing , Hu Renping , Zhu Jie , Yan Rong , Dai Kesheng 
Published: January 2017

BackgroundAlcohol abuse incurs severe medical conditions, such as thrombocytopenia and hemorrhage, but the pathogenesis is not totally understood. Alcohol has been reported to induce apoptosis in eukaryotic cells, such as hepatocyte, nerve cell, corneal fibroblasts. However, it is still unclear whether alcohol induces platelet apoptosis.MethodsWashed human platelets were pretreated with ethanol (EtOH), and apoptotic events and platelet function were detected. In in vivo experiments, C57BL/6J mice were given EtOH by gavage. Platelet counts, tail bleeding time, and the stomach were examined.ResultsEtOH dose dependently induces depolarization of mitochondrial inner transmembrane potential, up‐regulation of Bax, down‐regulation of Bcl‐2, and caspase‐3 activation. EtOH does not induce surface expression of P‐selectin or PAC‐1 binding, whereas significantly reduces collagen‐, thrombin‐, and ADP‐induced platelet aggregation. Moreover, EtOH induces c‐Jun NH2‐terminal kinase activation. In an in vivo mouse model of the acute alcoholism, EtOH significantly reduces the number of circulating platelets, prolongs the tail bleeding time, and causes gastric mucosa hemorrhage.ConclusionsThese data demonstrate that EtOH induces mitochondria‐mediated intrinsic platelet apoptosis, results in the reduction of the number of circulating platelets, and impairs in vivo hemostasis. These findings reveal the possible pathogenesis of hemorrhagic symptoms in patients experiencing acute alcohol intoxication.
Screening, brief intervention and referral to treatment (SBIRT): implementation barriers, facilitators and model migration
Authors: Vendetti Janice , Gmyrek Amanda , Damon Donna , Singh Manu , McRee Bonnie , Del Boca Frances 
Published: January 2017

AbstractAimsTo identify barriers and facilitators associated with initial implementation of a US alcohol and other substance use Screening, Brief Intervention, and Referral to Treatment (SBIRT) grant program, and to identify modifications in program design that addressed implementation challenges.DesignA mixed‐method approach used quantitative and qualitative data, including SBIRT provider ratings of implementation barriers and facilitators, staff interview responses and program documentation.SettingMultiple sites within the first seven programs funded in a national demonstration program in the United States.ParticipantsOne hundred and two SBIRT providers were surveyed; 221 SBIRT stakeholders and staff were interviewed.MeasurementsMean ratings of barriers and facilitators were calculated using provider survey responses. An inductive content analysis of interview responses identified factors perceived to support and challenge implementation; program modifications that occurred over time were recorded.FindingsProviders rated pre‐selected implementation facilitators higher than barriers. Content analysis of interview responses revealed six themes: committed leaders; intra‐ and inter‐organizational communication/collaboration; provider buy‐in and model acceptance; contextual factors; quality assurance; and grant requirements. Over time, programs tended to: adopt more efficient ‘pre‐screen’ item sets; screen for risk factors in addition to alcohol/substance use; use contracted specialists to deliver SBIRT services; conduct services in high‐volume emergency department and trauma center settings; and implement on‐site and telephonic treatment delivery.ConclusionsScreening, Brief Intervention and Referral to Treatment program implementation in the United States is facilitated by committed leadership and the use of substance use specialists, rather than medical generalists, to deliver services. Many implementation challenges can be addressed by an adequate start‐up phase focused on comprehensive education and training, and on the development of intra‐ and inter‐organizational communication and collaboration; opinion leader support; and practitioner and host site buy‐in.
The SBIRT program matrix: a conceptual framework for program implementation and evaluation
Authors: Del Boca Frances K. , McRee Bonnie , Vendetti Janice , Damon Donna 
Published: January 2017

AbstractBackground and AimsScreening, Brief Intervention and Referral to Treatment (SBIRT) is a comprehensive, integrated, public health approach to the delivery of services to those at risk for the adverse consequences of alcohol and other drug use, and for those with probable substance use disorders. Research on successful SBIRT implementation has lagged behind studies of efficacy and effectiveness. This paper (1) outlines a conceptual framework, the SBIRT Program Matrix, to guide implementation research and program evaluation and (2) specifies potential implementation outcomes.MethodsOverview and narrative description of the SBIRT Program Matrix.ResultsThe SBIRT Program Matrix has five components, each of which includes multiple elements: SBIRT services; performance sites; provider attributes; patient/client populations; and management structure and activities. Implementation outcomes include program adoption, acceptability, appropriateness, feasibility, fidelity, costs, penetration, sustainability, service provision and grant compliance.ConclusionsThe Screening, Brief Intervention and Referral to Treatment Program Matrix provides a template for identifying, classifying and organizing the naturally occurring commonalities and variations within and across SBIRT programs, and for investigating which variables are associated with implementation success and, ultimately, with treatment outcomes and other impacts.
Screening, Brief Intervention and Referral to Treatment: implications of SAMHSA's SBIRT initiative for substance abuse policy and practice
Authors: Babor Thomas F. , Del Boca Frances , Bray Jeremy W. 
Published: January 2017

AbstractAimsThis paper describes the major findings and public health implications of a cross‐site evaluation of a national Screening, Brief Intervention and Referral to Treatment (SBIRT) demonstration program funded by the US Substance Abuse and Mental Health Services Administration (SAMHSA).MethodsEleven multi‐site programs in two cohorts of SAMHSA grant recipients were each funded for 5 years to promote the adoption and sustained implementation of SBIRT. The SBIRT cross‐site evaluation used a multi‐method evaluation design to provide comprehensive information on the processes, outcomes and costs of SBIRT as implemented in a variety of medical and community settings.FindingsSBIRT programs in the two evaluated SAMHSA cohorts screened more than 1 million patients/clients. SBIRT implementation was facilitated by committed leadership and the use of substance use specialists, rather than medical generalists, to deliver services. Although the quasi‐experimental nature of the outcome evaluation does not permit causal inferences, pre–post differences were clinically meaningful and statistically significant for almost every measure of substance use. Greater intervention intensity was associated with larger decreases in substance use. Both brief intervention and brief treatment were associated with positive outcomes, but brief intervention was more cost‐effective for most substances. Sixty‐nine (67%) of the original performance sites adapted and redesigned SBIRT service delivery after initial grant funding ended. Four factors influenced SBIRT sustainability: presence of program champions, availability of funding, systemic change and effective management of SBIRT provider challenges.ConclusionsThe US Substance Abuse and Mental Health Services Administration's Screening, Brief Intervention and Referral to Treatment (SBIRT) demonstration program was adapted successfully to the needs of early identification efforts for hazardous use of alcohol and illicit drugs. SBIRT is an innovative way to integrate the management of substance use disorders into primary care and general medicine. Screening, Brief Intervention and Referral to Treatment implementation was associated with improvements in treatment system equity, efficiency and economy.