bluuebunny/crossref_metadata_2025_split huggingface dataset:
Late Pleistocene slip rate of the northern Qilian Shan frontal thrust, western Hexi Corridor, China
Authors: Liu Xing‐Wang , Yuan Dao‐Yang , Su Qi 
Published: May 2017

AbstractWe derive a slip rate for a frontal thrust in the western Hexi Corridor along the northern Qilian Shan by combining topographic profiling and 10Be exposure dating. The active Yumen‐Beidahe thrust fault offsets late Pleistocene alluvial‐fan deposits, and a prominent north‐facing scarp is well preserved. To quantify the slip rate, we surveyed the uplifted terraces and sampled quartz‐rich pebbles on terrace surfaces and river channels to determine surface exposure ages and pre‐depositional inheritance. The minimum vertical slip rate of the fault is 0.73 ± 0.09 mm a−1. This represents a horizontal shortening rate of 1.26 ± 0.31 mm a−1 for a fault dip of 30 ± 5°. This estimated slip rate supports the inference made from previous geological and GPS constraints that NNE‐directed shortening across the western Qilian Shan and the Hexi Corridor is distributed on several active faults with a total shortening rate of 4–10 mm a−1.
Platelet proteins cause basophil histamine release through an immunoglobulin‐dependent mechanism
Authors: Lee Donna Dong‐Young , Muskaj Igla , Savage William 
Published: May 2017

BACKGROUNDA general understanding of allergic transfusion reaction mechanisms remains elusive. Multiple mechanisms have been proposed, but none have been compared experimentally.STUDY DESIGN AND METHODSWe used histamine release (HR) from healthy human donor basophils to model allergic transfusion reactions. Platelet component supernatant (plasma), platelet lysate, and manipulated platelet lysates (dialyzed, delipidated, trypsinized, mild heat‐inactivated, and ultracentrifuged) were used to characterize allergic stimuli. Immunoglobulin‐dependent mechanisms were investigated through cell surface immunoglobulin depletion and ibrutinib signaling inhibition. HR induced by platelet mitochondria was compared with HR by platelet lysate with or without DNase treatment.RESULTSRobust, dose‐responsive HR to platelet lysate was observed in two of eight nulliparous, never‐transfused, healthy donors. No HR was observed with plasma. Among manipulated platelet lysates, only trypsin treatment significantly reduced HR (39% reduction; p = 0.008). HR in response to platelet lysate significantly decreased with either cell surface immunoglobulin depletion or ibrutinib pretreatment. Platelet mitochondria induced minimal basophil HR, and DNase treatment did not inhibit platelet lysate–induced HR.CONCLUSIONType I immediate hypersensitivity to platelet proteins may be an allergic transfusion reaction mechanism. Prior sensitization to human proteins is not required for basophil responses to platelet proteins. Further study into the relative contributions of hypersensitivity to platelet versus plasma proteins in transfusion is warranted.
Detection of Emerging Vaccine-Related Polioviruses by Deep Sequencing
Authors: Sahoo Malaya K. , Holubar Marisa , Huang ChunHong , Mohamed-Hadley Alisha , Liu Yuanyuan , Waggoner Jesse J. , Troy Stephanie B. , Garcia-Garcia Lourdes , Ferreyra-Reyes Leticia , Maldonado Yvonne , Pinsky Benjamin A. 
Published: May 2017

ABSTRACT
Oral poliovirus vaccine can mutate to regain neurovirulence. To date, evaluation of these mutations has been performed primarily on culture-enriched isolates by using conventional Sanger sequencing. We therefore developed a culture-independent, deep-sequencing method targeting the 5′ untranslated region (UTR) and P1 genomic region to characterize vaccine-related poliovirus variants. Error analysis of the deep-sequencing method demonstrated reliable detection of poliovirus mutations at levels of <1%, depending on read depth. Sequencing of viral nucleic acids from the stool of vaccinated, asymptomatic children and their close contacts collected during a prospective cohort study in Veracruz, Mexico, revealed no vaccine-derived polioviruses. This was expected given that the longest duration between sequenced sample collection and the end of the most recent national immunization week was 66 days. However, we identified many low-level variants (<5%) distributed across the 5′ UTR and P1 genomic region in all three Sabin serotypes, as well as vaccine-related viruses with multiple canonical mutations associated with phenotypic reversion present at high levels (>90%). These results suggest that monitoring emerging vaccine-related poliovirus variants by deep sequencing may aid in the poliovirus endgame and efforts to ensure global polio eradication.
Impact of two-step urine culture ordering in the emergency department: a time series analysis
Authors: Stagg Amanda , Lutz Haydon , Kirpalaney Sakshi , Matelski John Justin , Kaufman Adam , Leis Jerome , McCready Janine , Powis Jeff 
Published: May 2017

BackgroundDespite evidence against the use of antimicrobials for asymptomatic bacteriuria (ASB), they are frequently prescribed leading to unnecessary adverse events. Prior studies have shown that reducing unnecessary urine cultures (UCs) results in decreased antimicrobial utilisation for ASB. Emergency departments (EDs) submit the largest volume of UCs, yet efforts to limit overordering in this patient setting have had limited success.MethodsA new two-step model of care for urine collection, using a novel UC collection container, was implemented in the ED of a large community hospital. The collection system contains a preservative allowing UCs to be held at room temperature for up to 48 hours before processing. UCs were collected by front-line staff, but only processed in the microbiology lab if requested by ED physicians after clinical assessment.ResultsFollowing implementation there was a decrease in the percentage of weekly ED visits associated with a processed UC (5.97% vs 4.68%, p<0.001), a decrease in the percentage of monthly ED visits requiring a callback for positive urine culture (1.84% to 1.12%, p<0.001) and a decrease in antimicrobial prescriptions for urinary indication among admitted patients (20.6% to 10.9%, p<0.01). There was a false omission rate of 1.35% (95% CI 0.7% to 2.2%), yet no identified cases of untreated urinary tract infection (UTI), or significant change in repeat ED visits or ED length of stay.ConclusionsChanging to two-step urine culture ordering in the ED resulted in a decrease in UCs processed, callbacks for positive results and antimicrobial use without evidence of untreated UTIs. This model of care has strong potential to improve the use of hospital resources while minimising detection and inappropriate treatment of ASB.
Structure and evolution of the Bukhara-Khiva region during the Mesozoic: the northern margin of the Amu-Darya Basin (southern Uzbekistan)
Authors: Mordvintsev Dmitriy , Barrier Eric , Brunet Marie-Françoise , Blanpied Christian , Sidorova Irina 
Published: May 2017

Abstract
The Bukhara-Khiva region forms the northern margin of the Mesozoic Amu-Darya Basin. We reconstructed several cross-sections across this margin from subsurface data. The objectives included examining the structure of the Bukhara and Chardzhou steps and determining the tectonic–sedimentary evolution of the basin during the Jurassic. Subsequent to the Cimmerian collision in the Middle Triassic, an extensional event controlled the deposition of the Early–Middle Jurassic siliciclastic succession in the Bukhara-Khiva region. The main Late Palaeozoic inherited structures were reactivated as normal faults during this period. Continental coarse-grained siliciclastic sediments are mainly confined to the basal Lower Jurassic section, probably Pliensbachian–Toarcian in age, whereas marine siliciclastic sediments occur in the early Late Bajocian. In the Early–Middle Jurassic the Bukhara and Chardzhou steps were predominantly sourced by areas of relief, the remains of Late Palaeozoic orogens located to the north. The rate of extension significantly declined during the Middle Callovian–Kimmeridgian period. Deposition of the overlying Lower Cretaceous continental red-coloured clastic sediments was related to the interaction of basin subsidence, a fall in eustatic sea-level and sediment supply. Subsequent marine transgression in the Late Barremian, partially related to broad thermal subsidence in the Amu-Darya Basin, resulted in the deposition of an extensive Late Cretaceous clay–marl succession.
Well-data-based discrete fracture and matrix modelling and flow-based upscaling of multilayer carbonate reservoir horizons
Authors: Milliotte Caroline , Jonoud Sima , Wennberg Ole Petter , Matthäi Stephan K. , Jurkiw Alexandra , Mosser Lukas 
Published: May 2017

Abstract
Discrete fracture and matrix (DFM) homogenization, simultaneously capturing reservoir layers and contained fractures, is an alternative to discrete fracture network (DFN) upscaling. Here, the DFM approach was applied to a fractured carbonate reservoir. Honouring geostatistical data from well logs, near-well multilayer reservoir models were constructed and analysed. Fracture aperture variations were modelled with a new semi-analytical model including a special treatment of layer-restricted fractures. Important results concern both pre-processing of stochastically generated DFMs for finite-element meshing, and the ensemble permeability values obtained by numerical homogenization of single v. multilayer models, respectively. Upscaling by volume averaging of vertically stacked single-layer DFMs results only in a fraction of the equivalent horizontal permeability that is obtained by homogenization of the multilayer models. Inspection of the flow patterns shows that this discrepancy arises because many fractures contact each other at layer boundaries fostering cross-flow. This effect is further enhanced where fractures intersect multiple layers. Compared to earlier DFN models for this reservoir, the DFM-derived fracture and matrix ensemble permeabilities are up to four times higher, highlighting how important it is to include the rock matrix into equivalent permeability calculations.
Identification of a Novel ITGαvβ6-Binding Peptide Using Protein Separation and Phage Display
Authors: Altmann Annette , Sauter Max , Roesch Saskia , Mier Walter , Warta Rolf , Debus Jürgen , Dyckhoff Gerhard , Herold-Mende Christel , Haberkorn Uwe 
Published: May 2017

AbstractPurpose: Targeted therapies are regarded as promising approaches to increase 5-year survival rate of head and neck squamous cell carcinoma (HNSCC) patients.Experimental design: For the selection of carcinoma-specific peptides membrane proteome of HNO97 tumor cells fractionated by the ProteomeLab PF2D system and corresponding HNO97 cells were deployed for an alternating biopanning using a sunflower trypsin inhibitor1–based phage display (SFTI8Ph) library. Stability, binding properties and affinity of novel candidates were assessed in vitro using radio-HPLC, binding experiments and surface plasmon resonance assay (SPR), respectively. Subsequently, the affinity of the peptide was verified in situ by using peptide histochemistry, in vitro using flow cytometry, and in vivo by positron emissions tomography (PET/CT).Results: We identified a novel ITGαvβ6 binding peptide (SFITGv6) containing the amino acid sequence FRGDLMQL. SFITGv6 provides stability over a period of 24 hours and demonstrates high affinity (KD = 14.8 nmol/L) for ITGαvβ6. In HNO97 cells, a maximal uptake and internalization of up to 37.3% and 37.5%, respectively, was measured. Small-animal PET imaging and biodistribution studies of HNO97 xenografted Balb/c nu/nu mice showed tumor-specific accumulation of 68Ga- and 177Lu-labeled DOTA-SFITGv6, respectively, 30 to 60 minutes after injection. Moreover, peptide histochemistry revealed a strong and homogenous binding of biotin-labeled SFITGv6 to HNSCC tumors and breast- and lung cancer-derived brain metastases. Finally, first PET/CT scans of HNSCC and NSCLC patients displayed SFITGv6 accumulation specifically in tumors, but not in inflammatory lesions.Conclusions: Thus, SFITGv6 represents a novel powerful tracer for imaging and possibly for endoradiotherapy of ITGαvβ6-positive carcinoma. Clin Cancer Res; 23(15); 4170–80. ©2017 AACR.
Study of the Different Transmission Line Faults for a Grid Connected Wind Farm with Different Types of Control Method for RSC
Authors: Najafi Reza 
Published: May 2017

<p>Wind power stations, many located in remote areas; so they are characterized by weak grids and are often submitted to power system disturbance like faults. In this paper, the behaviour of a wind energy conversion system that uses the control of the rotor side converter (RSC) by three different methods under faulty conditions is presented. The behaviour of these systems during a grid failure is an important issue. DFIG is analysed and simulated under differing faulty conditions in the environment of MATLAB/SIMULINK. Simulation results show that the proposed method has proper operation during fault conditions.</p><p> </p>
A substantial peer workforce in a psychiatric service will improve patient outcomes: the case for
Authors: Dark Frances , Patton Murray , Newton Richard 
Published: May 2017

Objectives: This statement of opinion relates to an invited debate on the role of peer workers in psychiatric services during the Royal Australian and New Zealand College of Psychiatrists conference 2016. The views presented in this statement of opinion are those of the team for the affirmative. Conclusions: Peer workers are increasingly being employed within mental health services. Early adopters of this new workforce note advantages in terms of engagement of peers but also a bidirectional sharing of knowledge between clinicians and peer workers that has been mutually beneficial. Greater research and evaluation needs to occur to understand how best to incorporate peer workers into mental health care.
Frailty assessment instruments in heart failure: A systematic review
Authors: McDonagh Julee , Martin Lily , Ferguson Caleb , Jha Sunita R , Macdonald Peter S , Davidson Patricia M , Newton Phillip J 
Published: May 2017

Background: Frailty is an independent predictor of mortality across many conditions. Reported rates of frailty in heart failure range from 15% to 74%. There are several instruments available to assess frailty; however, to date there has been no consensus on the most appropriate instrument for use in individuals with heart failure. Aims: To identify how frailty is assessed in individuals with heart failure and to elucidate which domains of frailty are most frequently assessed. Methods: Key electronic databases were searched (MEDLINE, COCHRANE Central and CINAHL) to identify studies that assessed frailty in individuals with heart failure using a formal frailty instrument. Results: Twenty studies published in 24 articles were included, for which a total of seven unique frailty instruments were identified. The most commonly used instrument was the Frailty Phenotype ( n= 11), with the majority of studies using a modified version of the Frailty Phenotype ( n= 8). The second most commonly used instrument identified was the Comprehensive Geriatric Assessment ( n= 4). Conclusion: There is an increasing interest in the assessment of frailty, but, to date, there is no frailty instrument validated specifically in the heart failure population.
OS CAPSAD, AS COMUNIDADES TERAPÊUTICAS E O “USUÁRIO DE DROGAS”: POLÊMICAS E PARADOXOS
Authors: César Elisson Alexandre Ferreira , Rodrigues Luzania Barreto 
Published: May 2017

O trabalho ora proposto reflete sobre dados empíricos provenientes de três campos de investigação: 1) o Centro de Atenção Psicossocial Álcool e outras Drogas (CAPSad); 2) uma comunidade terapêutica de cunho evangélico; e 3) o Coletivo Ciranda de Rua de Redução de Danos, dispositivos de atenção e cuidado dispensados a usuários de substâncias psicoativas (SPA). Utilizando-se de algumas técnicas importantes ao trabalho etnográfico, como a observação participante, as conversas informais e as entrevistas gravadas, pôde-se aceder a questões que explicitam controvérsias quanto à prática da Política Nacional direcionada a este público específico, bem como desvela debates polêmicos sobre a incidência de padrões morais e normas de condu- ta no tratamento aí implicado, além de ser privilegiado o uso de fármacos em detrimento de outras medidas terapêuticas. Diante disso, atentamos para a necessidade premente de políticas eficazes de assistência social em consonância com uma assistência de saúde que possa contemplar as múltiplas dimensões que abarca o fenômeno estudado, seja em espaços institucionalizados ou em territórios de consumo.
O INSÓLITO NA OBRA DE JOÃO GILBERTO NOLL OU O APRENDIZADO DA TRANSGRESSÃO
Authors: Carreira Shirley De Souza Gomes Carreira 
Published: May 2017

Na literatura brasileira contemporânea, há autores que incorporam aos seus textos acontecimentos insólitos que devem ser observados à luz das teorias relativas ao insólito ficcional. Este trabalho tem por objetivo analisar o insólito na obra de João Gilberto Noll, de modo a comprovar que a sua presença nos textos do autor constitui uma via para transgressões que operam não apenas no âmbito da diegese, mas também na arquitetura do texto.
Nudging: ‘Soft’ mind-bending through politics and media – an issue for civil rights activists?
Authors: Piasecki Stefan 
Published: May 2017

Abstract
‘Nudging’, a form of motivational help to make people change their behaviour, habits or attitudes, is becoming more and more popular. While initially mainly used in sales, marketing and advertising, its principles and methods, also referred to as ‘behavioural design’ or ‘behavioural economics’, have been refined and expanded over the past 30 years, now making it also suitable for politics and public services. Nudging is and can be used to help people change their behaviour regarding energy consumption, health precautions etc. On the other hand, political nudging performed by authorities may, if carelessly performed, seriously damage the public trust. First the term and meaning of ‘nudging’ will be introduced. It has a much longer and richer history than recent mention in the German public sphere indicates. Then examples of current uses will be given and possible political and cultural implications will be discussed. This article refers to international sources and discourses but concentrates on shedding light on nudging in Germany.
Undocumented identity storytelling: (Re)framing public relations
Authors: Ortiz Juarez-Paz Anna V. 
Published: May 2017

Abstract
The Undocumented Student Movement (USM) consists of members of a historically misrepresented and excluded population in the United States. Taking matters into their own hands, they have gained a voice in mainstream media and society today. In this article, I seek to document the communicative acts of resistance employed by undocumented students in the United States. Specifically, I argue that the communicative acts currently employed by the USM answer the call for a more critical and engaged theory of public relations. The USM offers alternative ways to communicate with publics through the use of undocumented identity storytelling. By employing the culture-centred approach to communication, I examine undocumented identity storytelling through participant observation and in-depth interviews with members of the movement.
Combining different treatment philosophies and techniques to reach the desired treatment goal using butterfly system-customizing orthodontic treatment
Authors: Lekhadia Dhaval 
Published: May 2017

This case report describes the orthodontic treatment of an 18-year-old male patient who presented with Straight profile; tongue thrust habit, proclined upper incisors, generalised spacing in upper and lower arches, Katz's class II premolar relation unilaterally, class II canine relation unilaterally with increased overjet and overbite. A butterfly system was used in the treatment combined with frictionless biomechanics in the initial stage of treatment followed by continuous arch mechanics in the later part of treatment. A tongued crib was used to stop the tongue thrust habit along with one elastic swallow exercise. Micro-implant anchorage was used unilaterally in the upper arch for retraction of the entire segment and correction of the unilateral class II canine and premolar relationship. To avoid a dished in profile, a non-extraction treatment was executed. Final corrections of distally tipped canines were achieved using conventional Begg’s uprighting auxiliaries in the vertical slots of butterfly system in the finishing stage. The case was finished using bite settling elastics. Total treatment time was 1 year 2 months. Aesthetic and functional goals were achieved satisfactorily with proper selection of biomechanics.
Adversarial versus Inquisitorial Systems: Error and Valuation
Authors: Rajagopalan Shruti 
Published: May 2017

AbstractThis paper discusses valuation within the judicial processes by comparing the adversarial and inquisitorial systems of litigation. It evaluates adversarial and inquisitorial litigation on the legal systems’ ability to aid processes that lead to discovery of knowledge. It argues that much of the information required for accurate valuation must be discovered. While the adversarial method of litigation is essentially a competitive model of evidence production; the inquisitorial system comprises only the expert/principle searcher, and lacks a competitive discovery process. Therefore, as a system, adversarial litigation may be more conducive for error minimization in enforcing rules than inquisitorial litigation. On the question of business valuation of firms under Chapter 11, both the adversarial and inquisitorial systems are problematic, given that market competition leading to discovery of prices and valuation is impossible within the judicial system of valuation.
Crystal structure of 3-(2-amino-1,3-selenazol-4-yl)-2H-chromen-2-one – dimethylformamide (1/1), C15H15N3O3Se
Authors: Alias Nurul Zawani , Ahmad Wan Yaacob Wan , Hassan Nurul Izzaty , Yamin Bohari M. , Ngatiman Mohammad Fadzlee 
Published: May 2017

Abstract
C15H15N3O3Se, triclinic, P1̅ (no. 2), a = 9.5686(7) Å, b = 12.3795(9) Å, c = 14.7854(11) Å, α = 93.844(2)°, β = 106.344(2)°, γ = 110.816(2)°, V = 1543.4(2) Å3, Z = 4, R
gt(F) = 0.0489, wR
ref(F
2) = 0.1066, T = 300 K.
Safeguarding Our Genetic Resources with Libraries of Doubled-Haploid Lines
Authors: Melchinger Albrecht E , Schopp Pascal , Müller Dominik , Schrag Tobias A , Bauer Eva , Unterseer Sandra , Homann Linda , Schipprack Wolfgang , Schön Chris-Carolin 
Published: May 2017

Abstract
Thousands of landraces are stored in seed banks as “gold reserves” for future use in plant breeding. In many crops, their utilization is hampered because they represent heterogeneous populations of heterozygous genotypes, which harbor a high genetic load. We show, with high-density genotyping in five landraces of maize, that libraries of doubled-haploid (DH) lines capture the allelic diversity of genetic resources in an unbiased way. By comparing allelic differentiation between heterozygous plants from the original landraces and 266 derived DH lines, we find conclusive evidence that, in the DH production process, sampling of alleles is random across the entire allele frequency spectrum, and purging of landraces from their genetic load does not act on specific genomic regions. Based on overall process efficiency, we show that generating DH lines is feasible for genetic material that has never been selected for inbreeding tolerance. We conclude that libraries of DH lines will make genetic resources accessible to crop improvement by linking molecular inventories of seed banks with meaningful phenotypes.