bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short Communication: Assessment of genetic diversity in Lai (Durio kutejensis) local cultivars of Batuah (Indonesia) using ISSR marker
Authors: HANDAYANI FITRI , RAHAYU SRIWULAN PAMUJI 
Published: March 2017

Handayani F, Rahayu SP. 2017. Assessment of genetic diversity in Lai (Durio kutejensis) local cultivars of Batuah (Indonesia) using ISSR marker. Biodiversitas 18: 525-529. Lai is an indigenous germplasm of Kalimantan which has potency to be developed as superior tropical fruit. Lai has attractive flesh color from yellow to reddish orange which represents the high content of carotene with smooth aroma or odorless fruit, and fruit storage period which longer than durian. Unfortunately, nowadays there is limited scientific information about its genetic diversity as important basic information for genetic conservation and breeding program. Batuah village in Kutai Kartanegara District is one of the center of origin and center of diversity of Lai in East Kalimantan, Indonesia which has many local cultivars with superior traits. The aim of this research was to study the genetic diversity of eight Lai local cultivars of Batuah village using molecular marker of ISSR. The total genomic DNA of eight Lai cultivars was isolated and was then used as template in the PCR amplification reaction using 10 ISSR primers. The result shows that similarity coefficient of eight Lai cultivars ranged between 0,34 and 0,58. Seven cultivars were grouped in the same cluster with 0,44 of similarity coefficient, while Lai Durian was separated in 0,34 of similarity coefficient. Genetically, the most similar existing cultivars are Lai Kuning and Lai Belimbing with the similarity coefficient of 0,58.
A coherent modeling procedure to describe cell activation in biological systems
Authors: Scianna Marco , Colombi Annachiara 
Published: March 2017

Abstract
Biological systems are typically formed by different cell phenotypes, characterized by specific biological properties and behaviors. In particular, cells are able to undergo phenotypic transitions (i.e., activation or differentiation) upon internal or external stimuli. In order to take these phenomena into account, we here propose a modelling framework in which cell ensembles can be described collectively (i.e., through a distributed mass density) or individually (i.e., as a group of pointwise/concentrated particles) according to their biological determinants. A set of suitable rules involving the introduction of a cell shape function then defines a coherent procedure to model cell activation mechanisms, which imply a switch between the two mathematical representations. The theoretical environment describing cell transition is then enriched by including cell migratory dynamics and duplication/apoptotic processes, as well as the kinetics of selected diffusing chemicals inuencing the system evolution. Remarkably, our approach provides consistency of the same modeling framework across all types of cell representation, as it is suitable to cope with the often ambiguous translation of individual cell arguments (i.e., cell dimensions and interaction radii) into collective cell descriptions. Biologically relevant numerical realizations are also presented: in particular, they deal with phenotypic transitions within cell colonies and with the growth of a tumor spheroid. These phenomena constitute biological systems particularly suitable to assess the advantages of the proposed model and to analyze the role on cell dynamics both of relevant parameters and of the specific form given to the cell shape function.
Use of Traumatic Brain Injury Prediction Rules With Clinical Decision Support
Authors: Dayan Peter S. , Ballard Dustin W. , Tham Eric , Hoffman Jeff M. , Swietlik Marguerite , Deakyne Sara J. , Alessandrini Evaline A. , Tzimenatos Leah , Bajaj Lalit , Vinson David R. , Mark Dustin G. , Offerman Steve R. , Chettipally Uli K. , Paterno Marilyn D. , Schaeffer Molly H. , Wang Jun , Casper T. Charles , Goldberg Howard S. , Grundmeier Robert W. , Kuppermann Nathan ,   for the Pediatric Emergency Care Applied Research Network (PECARN),   Clinical Research on Emergency Services and Treatment (CREST) Network,   and Partners Healthcare; Traumatic Brain Injury-Knowledge Translation Study Group
Published: March 2017

OBJECTIVES:
We determined whether implementing the Pediatric Emergency Care Applied Research Network (PECARN) traumatic brain injury (TBI) prediction rules and providing risks of clinically important TBIs (ciTBIs) with computerized clinical decision support (CDS) reduces computed tomography (CT) use for children with minor head trauma.

METHODS:
Nonrandomized trial with concurrent controls at 5 pediatric emergency departments (PEDs) and 8 general EDs (GEDs) between November 2011 and June 2014. Patients were &lt;18 years old with minor blunt head trauma. Intervention sites received CDS with CT recommendations and risks of ciTBI, both for patients at very low risk of ciTBI (no Pediatric Emergency Care Applied Research Network rule factors) and those not at very low risk. The primary outcome was the rate of CT, analyzed by site, controlling for time trend.

RESULTS:
We analyzed 16 635 intervention and 2394 control patients. Adjusted for time trends, CT rates decreased significantly (P &lt; .05) but modestly (2.3%–3.7%) at 2 of 4 intervention PEDs for children at very low risk. The other 2 PEDs had small (0.8%–1.5%) nonsignificant decreases. CT rates did not decrease consistently at the intervention GEDs, with low baseline CT rates (2.1%–4.0%) in those at very low risk. The control PED had little change in CT use in similar children (from 1.6% to 2.9%); the control GED showed a decrease in the CT rate (from 7.1% to 2.6%). For all children with minor head trauma, intervention sites had small decreases in CT rates (1.7%–6.2%).

CONCLUSIONS:
The implementation of TBI prediction rules and provision of risks of ciTBIs by using CDS was associated with modest, safe, but variable decreases in CT use. However, some secular trends were also noted.
Transición del compromiso al cumplimiento: eficacia de los tribunales internacionales de derechos humanos
Authors: Komanovics Adrienne 
Published: March 2017

El hecho de que las leyes internacionales se caractericen por la falta de un sistema unificado de sanciones y de unas autoridades centrales encargadas de su ejecución, ciertamente debilita el carácter normativo de las obligaciones internacionales en el ámbito de los derechos humanos. Tras una breve descripción de los problemas teóricos y prácticos relativos al cumplimiento de las leyes internacionales, este artículo se centra en los retos contemporáneos con que se encuentran los mecanismos internacionales en el ámbito de los derechos humanos. Se dice que a pesar de la falta de aplicación centralizada, las últimas décadas han sido testigos de la intensificación y diversificación de los procedimientos de cumplimiento. Sin embargo, la brecha persistente entre el compromiso y el cumplimiento real pone en duda la eficacia de los organismos internacionales de derechos humanos. El artículo analiza las debilidades de la ejecución de las decisiones de los tribunales de derechos humanos, en particular a nivel universal y en el sistema regional europeo. Se argumenta que a pesar de los esfuerzos para fortalecer la supervisión internacional, todos los tribunales internacionales de derechos humanos se basan en la aplicación nacional. Por tanto, el cumplimiento depende en última instancia de la voluntad política de los Estados. A pesar de la relativa fortaleza del mecanismo de supervisión en el ámbito de los derechos humanos, el cumplimiento ha seguido siendo una cuestión interna.
Recensión AA.VV. (a cura di Christian Baldus et al.), Dogmengeschichte und Historische individualität der Römischen Juristen. Storia dei dogmi e individualità storica dei giuristi romani
Authors: Rodríguez Montero Ramón Perfecto 
Published: March 2017

Recensión AA.VV. (A cura di Christian Baldus, Massimo Miglietta, Gianni Santucci, Emanuele Stolfi), Dogmengeschichte und Historische individualität der Römischen Juristen. Storia dei dogmi e individualità storica dei giuristi romani. Atti del Seminario Internazionale (Montepulciano 14-17 giugno 2011). Quaderni del Dipartimento di Scienze Giuridiche, 107. Università degli Studi di Trento, 2012. 734 pp.
Modifications in Human Oral Fibroblast Ultrastructure, Collagen Production, and Lysosomal Compartment in Response to Electronic Cigarette Fluids
Authors: Sancilio Silvia , Gallorini Marialucia , Cataldi Amelia , Sancillo Laura , Rana Rosa Alba , di Giacomo Viviana 
Published: March 2017

Background: Many smokers have recently turned to electronic cigarettes (e‐cigarettes) because they have been marketed as a cheaper, safer smokeless alternative to traditional cigarettes and a possible smoking cessation tool. Although the safety of these electronic devices is still not fully known, there is evidence of their cytotoxicity on cells belonging to the oral cavity. In a previous study by the authors, the increase of reactive oxygen production and Bax expression, followed by the occurrence of apoptosis, was demonstrated in human gingival fibroblasts (HGFs). The aim of this paper is to further investigate the effects of the e‐cigarette liquids (with and without nicotine) on the same experimental model.Methods: HGFs were treated with e‐cigarette fluids containing nicotine (final concentration 1 mg/mL) and the equivalent volume of a fluid without nicotine, for periods ≤48 hours. Lactate dehydrogenase assay (LDH), electronic microscopy analysis, collagen I production, flow cytometry lysosome compartment evaluation, and western blotting light chain 3 (microtubule‐associated protein 1A/1B‐LC3) expression were performed.Results: Fluids containing nicotine exerted cytotoxicity as demonstrated by increased levels of LDH, in parallel to the presence of numerous vacuoles in the cytoplasm, a decrease in collagen I production, and augmented LC3 II expression. Autophagic vesicles and more procollagen I molecules were present in the cytoplasm of fibroblasts exposed to nicotine‐free fluids. In the same samples, time‐dependent activation of the lysosomal compartment with no changes in LC3 expression was detected.Conclusion: E‐cigarette fluids (with and without nicotine) trigger molecular and morphologic responses in oral fibroblasts, raising concerns about their role in the pathogenesis of oral diseases.
ENTREVISTA: PROFESSOR RICARDO TADEU LOPES
Authors: Ghetti Neuvânia Curty 
Published: March 2017

Em agosto de 2016, a revista Clio Arqueológica entrevistou o Professor Ricardo Tadeu. Formado em Física, com mestrado e doutorado em engenharia nuclear, é professor titular da UFRJ desde 2002. Inicialmente dedicou-se à produção de instrumentação nuclear, especificamente na construção de módulos eletrônicos, como instrumentos e detectores de irradiação. Atualmente o Professor Ricardo desenvolve suas pesquisas no laboratório de Instrumentação Nuclear. Esse laboratório vem migrando e ampliando sua área de atuação para outras técnicas de aplicações nucleares, entre as quais fazem parte a radiografia digital, a tomografia computadorizada e as técnicas analíticas de fluorescências por Raios X e de difração de Raios X. Essas duas últimas são as que ocupam a maior parte do tempo de suas pesquisas.
Integrative function of the university library: forms of implementation in the external informational-educational space
Authors: Mikhailova A. V. 
Published: March 2017

The article reveals the role of a university library in forming the united information-educational space. The higher institution library is considered as a backbone element of the information-educational space. A qualitative change in the library activities is emphasized by its ability to interact with other subjects of the educational space both within the university and beyond it.The university library has an integrative function providing the effect of the integrity of the information-educational space in two directions: internal and external ones. The emphasis is placed on the disclosing the integration external direction, that ensure the library access to the global information-educational spaces of the city, region, country, and world. Early forms of realizing the integration external direction are shown. First directions on the resources sharing are marked in organizing libraries interaction.The involved item modern state supposes using both traditional and electronic information resources, and new information technologies allow opening new forms of implementation of the integration external direction. Among them are consortia and corporations of university libraries of cities, regions, as well as other levels and departments. Libraries, becoming resource centers of universities and regions, create research-educational orientated resources; serve the university, municipal and regional circle of users, providing them with direct and remote access to all available resources. The integrative function content of university libraries is connected with creating a uniform information-educational space of the region, namely the unification of library activities of territorial entities (a region, a city) and libraries of other regional systems and departments (education, science, culture, etc.).The next form of implementing the integration external direction is participation of education institutions in development of the existing electronic library systems, i.e. interaction between electronic resources created by the universities of culture and arts, and external electronic resources available to students. Thus, integrative function of the university libraries includes supporting to fill external electronic library systems with the profile content (both educational and scientific character).The third form implementing the integration external direction is an integrated electronic library. It allows organizing the united information-educational space with the whole set of information-educational resources such as bibliographic, abstract, reference, analytical, full-text ones, etc., and the university library ensures its integrity thanks to its integrative function.
Cointegration and Causality Relationship Between Stock Market, Money Market and Foreign Exchange Market in Pakistan
Authors: Abbas Ghulam , Bhowmik Roni , Koju Laxmi , Wang Shouyang 
Published: March 2017

AbstractThis paper examines the relationship between stock market (KSE-100), money market (M2 and 180 days T-bill rate), and foreign exchange market (ER: PKR/USD) in Pakistan by using monthly data covering the period from 2000:M1 to 2015:M12. The study investigates long-run equilibrium relationship between these three financial markets by employing Johansen and Juselius[1] cointegration tests. Long-run and short-run causality relationship between stock market and other macroeconomic variables is also established by employing vector error correction model (VECM) and pairwise granger causality tests. The results of multivariate cointegration test (trace test) indicate a one cointegrating vector, and the significant normalized cointegrating coefficients are evident of long run equilibrium relationship between all the selected variables. Negative and significant ECT (− 1) for all variables during full sample period witness the presence of long-run causality connection among variables, while during the military regime and democratic regime, significant difference of long-run causal connections are identified across the regimes. Moreover, the results of granger causality test also indicate that there are significant variations in the causality relationship among variables across the regimes. Therefore, it is essential for forecasting, planning and policy making to consider the importance of political governance system while analyzing the historical cointegration among financial market and make the necessary adjustments accordingly.
Detecting Change-Point via Saddlepoint Approximations
Authors: Li Zhaoyuan , Tian Maozai 
Published: March 2017

AbstractIt’s well-known that change-point problem is an important part of model statistical analysis. Most of the existing methods are not robust to criteria of the evaluation of change-point problem. In this article, we consider “mean-shift” problem in change-point studies. A quantile test of single quantile is proposed based on saddlepoint approximation method. In order to utilize the information at different quantile of the sequence, we further construct a “composite quantile test” to calculate the probability of every location of the sequence to be a change-point. The location of change-point can be pinpointed rather than estimated within a interval. The proposed tests make no assumptions about the functional forms of the sequence distribution and work sensitively on both large and small size samples, the case of change-point in the tails, and multiple change-points situation. The good performances of the tests are confirmed by simulations and real data analysis. The saddlepoint approximation based distribution of the test statistic that is developed in the paper is of independent interest and appealing. This finding may be of independent interest to the readers in this research area.
A Safer Generation of Wettability Alteration Chemical Treatments
Authors: Sayed Mohammed , Al-Muntasheri Ghaithan 
Published: March 2017

Abstract
Substantial natural gas reserves are found in gas condensate reservoirs. As gas production takes place from these reservoirs, single phase gas flows as long as the bottomhole pressure is greater than the dew point pressure. With production, the flowing bottomhole pressure decreases and once it decreases below the dew point pressure, condensation of some of the heavy components in the gas stream occurs. This liquid condensate will accumulate in the area near the wellbore and form condensate banking, which adversely affects both the gas relative permeability and the well productivity.
Numerous methods have been utilized to mitigate the problem of condensate banking. One of the most effective methods is the use of wettability alteration chemicals to change the rock wettability from water/oil wet to preferentially gas wet. The main problem with the current wettability alteration chemical treatment is the treatment's low flash point, which makes it unsafe to be used in the summer time when temperatures in some parts of the world can be as high as 130°F (54.5°C).
The main objective of the current work is to develop a wettability alteration chemical with a high flash point to address this safety concern. Several additives and alternatives intended to increase the flash point were tested. The flash point temperature was measured for these new formulations, and contact angle, interfacial tension and coreflood experiments were performed to evaluate the newly developed treatment formulations.
Lab tests indicated that the flash point temperature of the treatment fluids increased from 22°C to approximately 67°C. The contact angle measurements indicated that the modified wettability alteration chemicals treatment fluid was able to modify the wettability of rock surfaces from complete water wetting to mixed wettability or even gas wetting. The contact angle between water and sandstone rock surfaces increased from 10° to 114° after treating the rocks with some of the new formulations. The pressure drop encountered while injecting different fluid systems decreased after treating the rock sample with a formulation that has 67°C flash point temperature. As an example, the formulation that has a flash point temperature of 67°C achieved an improvement factor of 1.55 in the condensate and gas relative permeabilities compared to an improvement factor of 1.7 that was achieved by using the low flash point fluid (flash point temperature is 22°C).
A higher flash point chemical treatment was developed to be used to mitigate the condensate banking problem. The newly developed formulations were able to modify the rock wettability from water and oil wetting to intermediate wettability or preferentially gas wetting.
Feasibility of Novel Techniques to Mitigate or Remedy CO2 Leakage
Authors: Pizzocolo F. , Peters E. , Loeve D. , Hewson C. W. , Wasch L. , Brunner L. G. 
Published: March 2017

Abstract
New ways to decrease the level of CO2 in the atmosphere are necessary to reduce the effects of the global warmimg. Subsurface CO2 storage has been identified as one of the key methods to reduce the emissions of CO2. The most crucial requirements that must be fulfilled to obtain a license for CO2 storage are: safety, reliability and the ability to remediate unwanted leakage. Remediation or mitigation of unwanted migration from storage sites requires new approaches for which the feasibility is yet to be demonstrated. The remediation technologies are classified as passive (e.g. stop injection) or active (e.g. producing or removing CO2). If passive methods are not enough to permanently stop the leakage, they need to be coupled with active approaches. The methodologies that we present in this work were stringently risk based, to ensures that the obtained results can be adopted to improve and help the regulatory process: protocols, safety regulations and guidelines. We studied the feasibility of some promising active technologies: 1. inject a chemical mixture near the location of leakage that reacts with the CO2 or formation water, forming solid reaction products; 2. inject heavy nanoparticles (NPs) and CO2 in a homogeneous mixture to increase the density of the CO2-saturated brine and consequentially escalating the dissolution rate of the CO2; 3. divert the injected CO2 from a leaky compartment of the reservoir to an adjacent compartment, separated by a sealing fault; 4. mitigate the CO2 leakage through natural faults located far from existing wells, transporting a polymer-gel by using man induced hydraulic fractures to drastically reduce the permeability of the fault; 5. transport foam to a leakage site to block CO2 from leaking out of a point leak. The results will be published in an interactive web-based tool, to advise and inform operators and authorities on the novel options that we investigated for remediation and mitigation.
Harmonic Pulse Testing for Well and Reservoir Characterization
Authors: Fokker Peter A. , Borello Eloisa Salina , Verga Francesca , Viberti Dario 
Published: March 2017

Abstract
For decades, well tests have been widely used in the oil industry for evaluation of well productivity and reservoir properties, which provide key information for field development and facilities design. In conventional well tests equilibrium conditions are required in the reservoir before the test. Furthermore, a single well only can be produced at a time, inducing one or more pressure draw-down periods followed by a final pressure build-up which are the object of the interpretation. Harmonic testing has been developed as a form of well testing that can be applied during ongoing production or injection operations, as a pulsed signal is superimposed on the background pressure trend. Thus no interruption of well and reservoir production is needed before and during the test. If the pulsed pressure and rate signal analysis is performed in the frequency domain, a strong similarity exists between the derivative of the harmonic response function versus the harmonic period and the pressure derivative versus time, typical of conventional well testing. Thus the interpretation of harmonic well tests becomes very straightforward.
In this paper, we present the derivation of type curves for the most commonly encountered well and reservoir scenarios and we validate the type-curves developed for horizontal wells against real data of a harmonic test performed on a gas storage well in Italy.