bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of late effects during a 21-year follow-up of pediatric Hodgkin lymphoma survivors: Experience of a pediatric cancer center in Turkey, as a developing country model
Authors: Tacyildiz Nurdan , Cakmak Hatice M , Unal Emel , Dincaslan Handan , Tanyıldız Gulsah , Özdemir Sonay İ , Kartal Ömer , Yılmaz Yasin , Yavuz Gulsan , Kuzu Işınsu 
Published: September 2024

Background:
Long-term survivors of Hodgkin lymphoma (HL) are at risk of developing a range of late effects, with a second malignant neoplasm and cardiovascular diseases being the leading causes of death in these patients. The present study aims to evaluate the late side effects in children with HL.

Materials and Methods:
Out of 53 HL patients, we assessed the long-term effects of childhood HL survivors (HLSs; n = 50) diagnosed between 1998 and 2019. Patient data related to chronic health conditions, and sociodemographic characteristics were compared with their siblings (n = 56).

Results:
The cumulative overall survival (OS) at 1, 5, and 10 years from diagnosis was 98.1 ± 1.9%, 93.3 ± 3.8%, and 93.3 ± 3.8%, respectively. Groups of HLSs and their siblings were matched according to age and gender. Compared with siblings, survivors had will be changed as ‘a higher frequency of nephrotoxicity (P = 0.02)’, cardiotoxicity (P = 0.12), thyroid dysfunction (P = 0.001), health care service usage (P < 0.01), limitation of physical function (P = 0.01), and pulmonary disease (P = 0.01). The control group of siblings had a higher incidence of marital status (P < 0.01), parenthood (P = 0.01), and smoking habit (P = 0.03). Thyroid dysfunction was associated with neck radiotherapy (P < 0.01). No secondary neoplasm was detected. In relapsed, refractory setting (n = 10), autologous transplantation (n = 9) is performed after a complete remission. Brentuximab vedotin with or without bendamustine and rituximab is also used in selected patients.

Conclusions:
Increased number of chronic health conditions and social problems point to the significance of long-term follow-up of HLSs. We are currently preparing a survivorship guideline appropriate for Turkey’s conditions.

Implications for Cancer Survivors:
Renal, heart, pulmonary impairment, thyroid dysfunction, limitation in physical functioning, and deterioration in social status (marriage, having children, education).
Tracing ocular biometry and their heritability in twins in a hospital-based cohort in South India
Authors: Paul Padma , Amritanand Anika , Jasper Smitha , Doss Prem , Samuel Prasanna , Chelliah Hepsy , Antonisamy Belavendra , Mackey David A 
Published: September 2024

Purpose:
Twin studies, in the background of lack of twin registry in India, are a challenge. We report the response rates in tracing a hospital birth register-based cohort of twins using mail and door to door survey, ocular parameters influencing refractive errors, and their heritability.

Methods:
Twins born from 1991 to 1995 in a tertiary hospital in the Vellore District of South India from a database were traced by mail and home survey from March 2011 to September 2013. Consenting live twin pairs who presented to the eye department were examined, including best corrected visual acuity, cycloplegic refraction, slit lamp examination, measurements of intraocular pressure (IOP) by Goldmann Applanation tonometry, axial length (AL) and anterior chamber depth (ACD), central corneal thickness (CCT), specular microscopy for endothelial count (EC), and a dilated fundus examination. Zygosity was determined by a validated zygosity questionnaire. Heritability was determined using the Falconers formula.

Results:
Postal contact was made in 14%, and a home visit was successful in another 23% of the cohort. Of those presenting for examination, 51.3% were found to be monozygous. Heritability (h2) of IOP was 0.34, that of ACD was 0.88, that of AL was 0.92, that of CCT was 0.96, and that of EC was 0.58.

Conclusion:
Tracing of twins using postal and home visits is challenging. Heritability for AL and CCT was found to be high, similar to that reported in other studies. This implies that a large proportion of variation found in AL and CCT is due to genetic causes as seen in twins from South India.
Corneal densitometry changes post-CXL for keratoconus: Comparative evaluation of epithelium-off, contact lens-assisted, and transepithelial techniques
Authors: Gupta Barkha , Malhotra Chintan , Dhar Supriya , Abhyapal Khushdeep , Jain Arun K. , Gupta Amit 
Published: September 2024

Purpose:
To evaluate changes in corneal backscattering after collagen cross-linking (CXL) for progressive keratoconus and compare its course with different techniques – standard epithelium-off CXL (SCXL), contact lens-assisted CXL (CACXL), and transepithelial CXL (TECXL).

Setting:
Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Design:
Retrospective comparative study.

Methods:
Ninety-four eyes (SCXL: 47, CACXL: 30, and TECXL: 17) were compared. Corneal haze was quantified using Scheimpflug tomography, pre- and post-CXL at 1, 3, 6, and 12 months.

Results:
The baseline mean density score of the central anterior stromal layer was 16.14 ± 7.07, 15.85 ± 7.89 and 15.89 ± 7.21 in SCXL, CACXL, and TECXL groups, respectively (P 0.93). After SCXL, the score increased to 28.83 and 31.34 at 1 and 3 months, respectively (both P < 0.001) and dropped at 6 months (28.66, P < 0.001) and 12 months (23.72, P 0.003). Post-CACXL, the mean densitometry peaked at 3 months (20.35, P 0.14) and returned toward baseline at 6 months (18.82, P 0.15). After TECXL, it increased slightly at 1 month (18.47, P 0.17), decreased at 3 months (14.88, P 0.7), and plateaued over 1 year. No correlation with visual acuity was seen.

Conclusion:
Corneal haze increased significantly after SCXL, peaking at 3 months, declining over 6–12 months, and returning to baseline at 12 months. In contrast, post-TECXL and -CACXL, there was an insignificant increase in anterior corneal haze, which returned to baseline within 3–6 months.
Bedside bilateral sequential intravitreal anti-VEGF injections for retinopathy of prematurity
Authors: Bajgai Priya , Satavisa Susree , Das Taraprasad , Jalali Subhadra , Samanataray Balakrushna , Nayak Sameera , Padhi Tapas Ranjan 
Published: September 2024

Purpose:
To evaluate the outcome and ocular adverse events of bedside bilateral sequential intravitreal anti-vascular endothelial growth factor injections for retinopathy of prematurity (ROP) (BBSIR).

Methods:
This retrospective interventional study included infants who received BBSIR with a follow-up of at least 1 month. Clinical history, intravitreal injection details, indications, intraoperative and postoperative ocular adverse events, and outcomes were analyzed.

Results:
The study cohort included 192 babies (384 eyes) spread over 9 years. The mean gestational age was 30.2 ± 2.6 weeks (28.8–34.1), and the birth weight was 1098.11 ± 271.65 g (650–2000). The indications for BBSIR were as follows: 73.4% (n = 141 infants) were too sick to transfer to an ophthalmic unit, 10.9% (n = 21 infants) due to the parents’ inconvenience of traveling to the ophthalmic center, and 15. 6% (n = 30 infants) due to both reasons. The injections were given by an ROP specialist/ROP-trained ophthalmologist after due parental consent, considering each eye as a fresh eye with separate scrubbing and draping. Light from the head-worn indirect ophthalmoscope served as the source of illumination. The retinopathy was regressing/regressed in 92.4% of babies until the last follow-up. The major ocular complication was cataract in 2 eyes (0.5%). There was no incidence of endophthalmitis till last follow-up (median 5.7 months).

Conclusions:
As per this study, BBSIR was observed to be effective and safe if given by those fully trained in the management of ROP. Though the rate of complications like cataract is small, they can pose management challenges and impact vision in a growing child.
Retinopathy and vision-related quality of life in blood dyscrasias
Authors: Mohanty Lipa , Kachhwaha Appurv , Sharma Alokit 
Published: September 2024

Purpose:
To study the association of retinopathy with vision-related quality of life in patients with blood dyscrasias.

Settings and Design:
A cross-sectional observational study was conducted at a university-based hospital.

Methods:
Two hundred patients with blood dyscrasias underwent comprehensive ocular examination, including dilated fundus examination. Vision-related quality of life was assessed using the National Eye Institute Visual Functioning Questionnaire-25 (NEI-VFQ-25).

Results:
Retinopathy was observed in 99 out of 200 patients (49.50%) with blood dyscrasias. The most common retinal findings were venous tortuosity with dilation (31.70%), intraretinal hemorrhages (27.88%), soft exudates (12.50%), white-centered hemorrhages (12.50%), and arteriolar attenuation (12.50%). A significant association was found between retinopathy in blood dyscrasias and NEI-VFQ subscales of general vision (P value: 0.01**), near activities (P value: 0.04*), distance activities (P value: 0.01**), mental health (P value: 0.01**), color vision (P value: 0.01**), peripheral vision (P value: 0.01**), role difficulties (P value: 0.01**), and social functioning (P value: 0.01**).

Conclusion:
The study highlights the prevalence of retinopathy in blood dyscrasia patients and its detrimental impact on vision-related quality of life. Regular fundus examinations are imperative for early detection and management of retinopathy to prevent significant visual impairment. Further research is warranted to elucidate underlying mechanisms and improve clinical management strategies.
Multidisciplinary Approach to Bilateral Pneumonia in a Toddler with Foreign Body Inhalation
Authors: Alshehri Abdulaziz Ahmed , Alshahrani Khalid Abdulaziz Abdullah , Alamrai Bandar Mahfouz Hamed , Alharthi Bassam Turki Matouq , Alotaibi Ghaida Hassan , Asiri Majed M. , Pullishery Fawaz 
Published: September 2024

Abstract
Foreign body inhalation (FBI) is a critical pediatric emergency that requires prompt recognition and intervention to prevent significant morbidity and mortality. It often presents with respiratory distress and can lead to complications such as pneumonia, atelectasis, and respiratory failure. While common in children aged 1–3 years, FBI is a rare occurrence necessitating immediate medical attention. We present a case of a 2-year-old male child admitted to the pediatric intensive care unit due to bilateral pneumonia complicated by a history of FBI. The management of such cases involves a multidisciplinary approach, including pediatricians, pulmonologists, and otolaryngologists, with bronchoscopy being the mainstay diagnostic and therapeutic procedure. This case underscores the importance of vigilance in diagnosing FBI in pediatric patients presenting with respiratory symptoms. Prompt identification and removal of the FB are crucial in preventing further complications and ensuring optimal patient outcomes.
Referral Policies for Patients with Hearing Difficulties: The Recommendations of the Saudi Otorhinolaryngology Society
Authors: Aljazeeri Isra , Abdelsamad Yassin , Altamimi Fahad , Alshehri Hassan , Telmesani Laila M , Alsabilah Rabea , Alenzi Saad , Alghamdi Saeed , Alahmari Yahya Dhafer , Hagr Abdulrahman , Alzhrani Farid 
Published: September 2024

Abstract

Background:
The management options for hearing difficulties and the indications for implantable hearing devices have expanded greatly over time, providing an opportunity to treat most hearing disabilities. However, the current clinical practice can miss a large number of potential candidates due to improper referrals. Up until today, the referral criteria in Saudi Arabia are not well defined and depend on the judgment of the referring practitioner. This study aims to provide a guide for the referral of patients with hearing difficulties.

Materials and Methods:
An expert panel of practicing professionals formed a core committee to carry out the process of developing this study. A comprehensive review was carried out to identify the current best evidence on the topic and to guide the core committee in developing the statements. For statement evaluation, we employed the Delphi consensus method, where the practicing otologists were invited to vote.

Results:
Seventeen preliminary statements were included in the original draft. Thirty-seven otologists were invited to vote, out of which 33 provided their responses. In the first voting round, consensus was reached on 16 statements (94%). The mean level of agreement was 95% (±5) for all the preliminary statements.

Conclusion:
This paper includes recommendation statements developed and approved by the SORL Society after review of the existing literature, using the Delphi consensus process. These statements may provide utility as evidence-based guide to improve patients’ access to hearing care services.
P. A. Kulakovsky — Correspondent of “Novoe Vremya”
Authors: Котов А.Э. 
Published: September 2024

П. А. Кулаковский (1848–1913) принадлежал к младшему поколению славянофилов. Еще в студенческие годы сойдясь с И. С. Аксаковым и Ю. Ф. Самариным, он одновременно ориентировался и на публицистику М. Н. Каткова, выходя, таким образом, за рамки «старого» славянофильского кружка. Научные труды Кулаковского, такие как «Вук Караджич» и «Иллиризм», пусть и уступая своим масштабом работам Н. Я. Данилевского и В. И. Ламанского, тем не менее являются значительным вкладом в отечественную славистику того периода. Как и многие гуманитарные исследования того времени, они были не лишены публицистического элемента, однако и последний, как правило, носил концептуальный характер. С конца 1870‑х гг. Платон Андреевич вел и собственно публицистическую деятельность. Его многочисленные корреспонденции с Балкан знакомили русского читателя с общественно-политической и культурной жизнью в славянских странах. Главным для Кулаковского изданием была газета «Русь» И. С. Аксакова. Охотно публиковался он и в «Московских ведомостях» М. Н. Каткова, хоть и выражал недовольство редакторской политикой последнего. Третьим изданием, в котором с конца 1870‑х печатались статьи Кулаковского, было «Новое время» А. С. Суворина. Из наиболее значимых публикаций, вышедших на страницах этой газеты, следует отметить статьи, посвященные преподаванию русского языка в Сербии, сербскому династическому кризису 1882 г., а также цикл писем из Хорватии, посвященных событиям 1884 г.
P. A. Kulakovsky (1848–1913) belonged to the younger generation of Slavophiles. Even in his student years, having become friends with I. S. Aksakov and Yu. F. Samarin, he was simultaneously guided by the journalism of M. N. Katkov, thus going beyond the scope of the “old” Slavophile circle. Kulakovsky’s scientific works, such as “Vuk Karadzic” and “Illyrism,” although inferior in scale to the works of N. Ya. Danilevsky and V. I. Lamansky, nevertheless, are a significant contribution to Russian Slavic studies of that period. Like many humanitarian studies of that time, they were not without a journalistic element, however, the latter, as a rule, was of a conceptual nature. Since the late 1870s. Platon Andreevich also conducted journalistic activities. His numerous correspondences from the Balkans introduced the Russian reader to the socio-political and cultural life in the Slavic countries. The main publication for Kulakovsky was the newspaper “Rus” by I. S. Aksakov. He also willingly published in M. N. Katkov’s “Moskovskie Vedomosti”, although he expressed dissatisfaction with the latter’s editorial policy. The third newspaper, in which Kulakovsky’s articles were published from the late 1870s, was “Novoe Vremya” of A. S. Suvorin. Among the most significant publications published on the pages of this newspaper, it should be noted articles devoted to the teaching of the Russian language in Serbia, the Serbian dynastic crisis of 1882, as well as a series of letters from Croatia dedicated to the events of 1884.
Aligning Cultural Tourism with SDGS: A Recommendation System Based on Frequent Patterns, Associations, and Correlations
Authors: Ritthipakdee Amarita , Ryu Keun Ho , Visutsak Porawat 
Published: September 2024

Objective: This study develops a recommendation system for cultural attractions in Bangkok, aligning with the Sustainable Development Goals (SDGs). The system aims to streamline travel planning and enhance tourist experiences by suggesting relevant attractions based on location and interests.

Theoretical Framework: The research utilizes association rules and data mining to identify patterns in tourist behavior, and recommender systems to provide personalized suggestions. It also incorporates principles of sustainable tourism, balancing economic, social, and environmental considerations.

Method: Data on 30 cultural attractions along Bangkok's BTS Skytrain green line was collected through interviews and questionnaires. The FP-Growth algorithm identified patterns and associations, generating rules for recommending attractions based on proximity and interests, while considering SDG alignment (cultural heritage, local communities, environmental impact). The method's performance was compared to decision tree and random forest approaches.

Results and Discussion: The proposed method generated five rules, achieving accuracy between 68.69% and 87.38%, outperforming the benchmark methods. The system's potential to improve tourist experiences, promote sustainable tourism, and aid urban planning is highlighted. Limitations include the dataset size and focus on a single transit line, suggesting future expansion and integration with SDG considerations.

Research Implications: The system can be integrated into platforms to provide personalized, SDG-conscious recommendations, enhancing experiences and encouraging responsible tourism. The study showcases data analytics' value in aligning tourism with the SDGs.

Originality/Value: The research introduces a novel approach, applying association rules for cultural attraction recommendations in Bangkok with an explicit SDG focus. The system's personalized recommendations based on location, interests, and SDG alignment streamline travel planning, foster fulfilling experiences, and contribute to the global sustainable development agenda.
Preventing Tax Base Erosion from Tax Treaty Abuse For SDGS in Vietnam
Authors: Nguyen Thuy Trang , Vuong Thị Thu Hien , Nguyen Dinh Chien 
Published: September 2024

Objective: Tax treaties represent an important aspect of the international tax rules of many countries, especially in globalizing era. The taxing rights of the states is one of the biggest issues in cross border transactions because it decides the budget revenue deriving from tax. Tax base, tax base erosion and tax base erosion prevention are topics that have received a lot of attention recently in Vietnam in order to protect government’s revenue for sustainable development goals (SDGs).

Method: By analyzing the current status of Vietnam's double taxation agreements (DTAs), the authors assessed the current situation and identifying risks of tax base erosion from abusing Vietnam's DTAs. The study focuses on analyzing the indicators to assess the content of DTAs such as the Source Index (SI), Permanent Establishment Index (PEI) and Withholding Tax Index (WHT) of Vietnam’s DTAs with the ones of groups of countries.

Results: The authors found that there are loopholes in DTAs creating conditions for abuses of the terms of the agreements and causing tax base erosion in Vietnam. Comparing to the average level of developing countries, the DTA system of Vietnam is higher, however, the biggest limitation and the biggest risk from the system of DTAs are these agreements are agreements signed by Vietnam with the countries/territories that have the lowest scores and are in the group of countries/territories with the largest amount of investment capital in Vietnam.

Contribution: The study makes some recommendations for Vietnam to prevent tax base erosion from tax treaty abuse by reviewing and considering negotiating to update the content of the bilateral tax agreements, promoting participation in multilateral tax agreement and improving efficiency of tax audit.
Comparison Among Deep Learning Approaches and Biomarkers in Early Detection of Parkinson's Disease
Authors: Goswami Gunjan , Prasad Bhanu 
Published: September 2024

Parkinson's disease (PD) is a chronic neurodegenerative disorder that is affecting millions of people worldwide. There is a lot of research reported on using different biomarkers and different deep learning (DL) approaches for the early detection of PD. However, there is no research reported on which biomarker is better suited when a specific DL model is used and vice versa. This research is aimed at addressing this issue. We use two widely used DL-based methods, Autoencoder (AE)-based and Convolution Neural Network (CNN)-based, to find out which one is better suited for PD classification when imaging, voice, and cerebrospinal fluid (CSF) biomarkers are used for evaluation. Further, we explore which biomarker, among imaging, voice, and CSF, is better suited for PD classification when the AE-based approach and CNN-based approach are used for evaluation. Two variants of AE-based approaches, Sparse AE (SAE) and Stacked Sparse AE (SSAE), are implemented in this research. The biomarkers' values are used from publicly available databases. Various experiments are conducted by using several performance parameters, and it is observed that (i) SSAE is better than SAE as well as CNN for the considered MRI, CSF, and voice features, based on the average of all the performance parameters' values for training as well as for testing datasets, and (ii) MRI is better than CSF as well as voice features for the considered SAE, SSAE, and CSF frameworks, based on the average of all the performance parameters' values, for training as well as for testing databases: for training databases, these values are 91.83% for MRI features, 84.55% for voice features, and 74.88% for CSF, and for testing databases, these values are 96.53 % for MRI features, 92.08 % for voice features, and 85.51% for CSF.

Received: 7 April 2024 | Revised: 13 June 2024 | Accepted: 17 July 2024

Conflicts of Interest
The authors declare that they have no conflicts of interest to this work.

Data Availability Statement
The voice datasets that support the findings of this study are openly available at https://archive.ics.uci.edu/dataset/174/parkinsons. The MRI and CSF data that support the findings of this study are openly available in PPMI at https://www.ppmi-info.org.

Author Contribution Statement
Gunjan Goswami: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Resources, Data curation, Writing – original draft, Visualization, Project administration. Bhanu Prasad: Conceptualization, Methodology, Software, Validation, Formal analysis, Investigation, Writing – review & editing, Visualization, Supervision, Project administration.