bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognition and psychopathology in first-episode psychosis: are they related to inflammation?
Authors: Cabrera B. , Bioque M. , Penadés R. , González-Pinto A. , Parellada M. , Bobes J. , Lobo A. , García-Bueno B. , Leza J. C. , Bernardo M. 
Published: April 2016

BackgroundCognitive deficits are present from the onset of psychosis and are considered a core feature of the disorder. Increasing evidence suggests that cognitive function is associated with inflammatory processes. This study evaluated the association between cognition and inflammatory biomarkers in first-episode psychosis (FEP), in order to identify cognitive phenotypes from inflammatory expression profiles.MethodA case-control study of 92 FEP patients and 80 matched controls was used. Neurocognitive assessment, including verbal ability, sustained attention, verbal memory, working memory and executive function, was performed. The expression of pro- and anti-inflammatory mediators of the main intracellular inflammatory pathway was measured in peripheral blood mononuclear cells and plasma.ResultsFEP patients performed worse in all cognitive domains compared to controls and had higher expression of pro-inflammatory mediators and lower expression of anti-inflammatory mediators. In the FEP group, cognition and psychopathology were associated with inflammation. Hierarchical regression analysis showed that association between the anti-inflammatory prostaglandin 15d-PGJ2and sustained attention on one hand, and COX-2 expression and executive function on the other, were statistically significant.ConclusionsOur study provides evidence for an association between anti-inflammatory biomarkers and cognition in FEP. The identification of a subgroup of patients based on these measures could be useful to guide treatment programmes by providing tools to select a personalized treatment approach, but longitudinal studies are needed before. In the future, establishment of biomarkers linked to cognition would be useful to monitor the course of cognitive impairment, but substantially more data will be required. Determination of IκBα, the inhibitory protein of the pro-inflammatory transcription factor NFκB, could be useful in early phases to assess clinical severity.
Crux probat omnia: Rowan Williams’ scriptural hermeneutic
Authors: Taylor Derek W. 
Published: April 2016

AbstractAlthough Rowan Williams is widely recognised as one of today's leading theologians, comparatively little attention has been paid to his scriptural hermeneutic, and much of what has been written has been critical of the role scripture plays in his theology. This article explores Williams’ biblical hermeneutic in light of the criticism of John Webster in particular. It is argued that for Williams a good reading of scripture must be at once critical, analogical, and christological. While this last characteristic is often overlooked by his critics, Williams’ emphasis on the risen Christ's ongoing presence in the church, and on the specifically cruciform nature of that presence, is determinative for his hermeneutic.
Finkenwalde - an experiment to restore a failing ecclesiology?
Authors: Fergus Donald 
Published: April 2016

AbstractThis paper considers Dietrich Bonhoeffer's understanding of the theological dimension of the concept of Christian community and in particular his conviction that believers must avoid the confusion that follows when ‘community romanticism’ (Gemeinschaftsromantik) is equated with the community of saints (Gemeinschaft der Heiligen). Bonhoeffer insisted that the task of building Christian community was one of crafting a space in which Jesus stands between believers, protecting them from the ‘damage of sheerly human immediacy’.1Without Jesus' mediating presence he believed, everything could go badly wrong.
Why do older adults avoid seeking financial advice? Adviser anxiety in the Netherlands
Authors: VAN DALEN HENDRIK P. , HENKENS KÈNE , HERSHEY DOUGLAS A. 
Published: April 2016

ABSTRACTWhy is it that many people fail to seek retirement planning advice when doing so is clearly indicated? Distrust of financial intermediaries is often presented as the common answer. But this paper shows that trust issues are only part of the answer; an appreciable proportion of individuals experience anxiety at the prospect of visiting a financial adviser. In the present investigation, financial adviser anxiety is studied among 950 Dutch adults over the age of 50. Anxiety levels were measured using a six-item scale that was administered as part of a larger nationwide investigation on retirement attitudes and behaviour. Findings revealed that nearly one-third of respondents reported having moderate to severe levels of anxiety at the prospect of visiting a financial professional. Furthermore, a hierarchical regression analysis revealed that strong predictors of anxiety included one's educational level, income, age, level of future time perspective, risk tolerance, financial knowledge and scepticism regarding whether advice from a financial professional can be trusted. A cluster analysis using demographic and psychological covariates identified three separate groups of older adults that were found to differ in terms of their mean level of anxiety. Those who had low levels of education and low incomes were found to disproportionately display high levels of financial adviser anxiety.
Complete Bredon cohomology and its applications to hierarchically defined groups
Authors: NUCINKIS BRITA E. A. , PETROSYAN NANSEN 
Published: April 2016

AbstractBy considering the Bredon analogue of complete cohomology of a group, we show that every group in the class$\cll\clh^{\mathfrak F}{\mathfrak F}$of type Bredon-FP∞admits a finite dimensional model for$E_{\frak F}G$.We also show that abelian-by-infinite cyclic groups admit a 3-dimensional model for the classifying space for the family of virtually nilpotent subgroups. This allows us to prove that for$\mathfrak {F}$, the class of virtually cyclic groups, the class of$\cll\clh^{\mathfrak F}{\mathfrak F}$-groups contains all locally virtually soluble groups and all linear groups over${\mathbb{C}}$of integral characteristic.
Interstage somatic growth in children with hypoplastic left heart syndrome after initial palliation with the hybrid procedure
Authors: Chan Fiona T. S. , Bellsham-Revell Hannah R. , Duggan Hannah , Simpson John M. , Hulse Tony , Bell Aaron J. 
Published: April 2016

AbstractIntroductionThe hybrid procedure is one mode of initial palliation for hypoplastic left heart syndrome. Subsequently, patients proceed with either the “three-stage” pathway – comprehensive second stage followed by Fontan completion – or the “four-stage” pathway – Norwood procedure, hemi-Fontan, or Fontan completion. In this study, we describe somatic growth patterns observed in the hybrid groups and a comparison primary Norwood group.MethodsA retrospective analysis of patients who have undergone hybrid procedure and Fontan completion was performed. Weight-for-age and height-for-age z-scores were recorded at each operation.ResultsWe identified 13 hybrid patients – eight in the three-stage pathway and five in the four-stage pathway – and 49 Norwood patients. Weight: three stage: weight decreased from hybrid procedure to comprehensive second stage (−0.4±1.3 versus −2.3±1.4, p<0.01) and then increased to Fontan completion (−0.4±1.5 versus −0.6±1.4, p<0.01); four stage: weight decreased from hybrid procedure to Norwood (−2.0±1.4 versus −3.3±0.9, p=0.06), then stabilised to hemi-Fontan. Weight increased from hemi-Fontan to Fontan completion (−2.7±0.6 versus −1.0±0.7, p=0.01); primary Norwood group: weight decreased from Norwood to hemi-Fontan (p<0.001) and then increased to Fontan completion (p<0.001). Height: height declined from hybrid procedure to Fontan completion in the three-stage group. In the four-stage group, height decreased from hybrid to hemi-Fontan, and then increased to Fontan completion. The Norwood group decreased in height from Norwood to hemi-Fontan, followed by an increase to Fontan completion.ConclusionIn this study, we show that patients undergoing the hybrid procedure have poor weight gain before superior cavopulmonary connection, before returning to baseline by Fontan completion. This study identifies key periods to target poor somatic growth, a risk factor of morbidity and worse neurodevelopmental outcomes.
Perception of Communicative and Non-communicative Motion-Defined Gestures in Parkinson’s Disease
Authors: Jaywant Abhishek , Wasserman Victor , Kemppainen Maaria , Neargarder Sandy , Cronin-Golomb Alice 
Published: April 2016

AbstractObjectives: Parkinson’s disease (PD) is associated with deficits in social cognition and visual perception, but little is known about how the disease affects perception of socially complex biological motion, specifically motion-defined communicative and non-communicative gestures. We predicted that individuals with PD would perform more poorly than normal control (NC) participants in discriminating between communicative and non-communicative gestures, and in describing communicative gestures. We related the results to the participants’ gender, as there are gender differences in social cognition in PD. Methods: The study included 23 individuals with PD (10 men) and 24 NC participants (10 men) matched for age and education level. Participants viewed point-light human figures that conveyed communicative and non-communicative gestures and were asked to describe each gesture while discriminating between the two gesture types. Results: PD as a group were less accurate than NC in describing non-communicative but not communicative gestures. Men with PD were impaired in describing and discriminating between communicative as well as non-communicative gestures. Conclusions: The present study demonstrated PD-related impairments in perceiving and inferring the meaning of biological motion gestures. Men with PD may have particular difficulty in understanding the communicative gestures of others in interpersonal exchanges. (JINS, 2016, 22, 1–11)
Preservation of the Semantic Verbal Fluency Advantage in a Large Population-Based Sample: Normative Data from the TILDA Study
Authors: Vaughan Roisin M. , Coen Robert F. , Kenny RoseAnne , Lawlor Brian A. 
Published: April 2016

AbstractObjectives: It is widely believed that phonemic fluency is more difficult than naming exemplars from a semantic category. Normative data in this regard are scarce, and there is considerable disagreement in the literature regarding the pattern in normal ageing and neurodegenerative conditions. Our objective was to provide normative data for semantic phonemic discrepancy scores from a large sample of older adults. Methods: A total of 5780 community-dwelling older adults were included in this prospective, longitudinal study. Discrepancy scores were calculated by subtracting phonemic fluency score from semantic fluency score for each participant. Quantile regression was used to estimate normative values stratified for age. Results: Subjects did better on testing of semantic fluency. The average discrepancy score was 9.18±6.89 words, (range, −20 to 37; n=5780). At the fiftieth percentile, those in their fifth decade produced 10 more “animals” than “letter F” words. Subjects scored one word less per decade, with an average of seven more “animal” words produced by those in their eighth decade. Conclusions: Our study is the first to provide normative data and confirms that, for animal versus letter F fluency, the semantic advantage persists into later life in a population-based sample of community-dwelling older adults. Given that a majority of clinical samples have confirmed a reverse of this pattern in Alzheimer’s dementia (i.e., loss of semantic advantage in Alzheimer’s disease, yielding a phonemic advantage), our findings support the clinical utility of brief fluency tests and encourage further research into their use in diagnosis and prediction of progression to dementia. (JINS, 2016, 22, 1–7)
Impact of prenatal exposure to polycyclic aromatic hydrocarbons from maternal diet on birth outcomes: a birth cohort study in Korea
Authors: Lamichhane Dirga Kumar , Leem Jong-Han , Kim Hwan-Cheol , Lee Ji-Young , Park Myung-Sook , Jung Dal-Young , Ko Jung Keun , Ha Mina , Kim Yangho , Hong Yun-Chul , Ha Eun-Hee 
Published: April 2016

AbstractObjectivePolycyclic aromatic hydrocarbons (PAH) are common dietary exposures that cross the human placenta and are classified as a probable human carcinogen. The aim of the present study was to investigate the potential impact of exposure to PAH-containing meat consumed during pregnancy on birth outcomes.DesignProspective birth cohort study. Only non-smoking women with singleton pregnancies, who were free from chronic disease such as diabetes and hypertension, were included in the study. Maternal consumption of PAH-rich meat was estimated through FFQ. Multiple linear regression was used to assess factors related to higher intake and the association between dietary PAH and birth outcomes.SettingRepublic of Korea, 2006–2011.SubjectsPregnant women (n 778) at 12–28 weeks of gestation enrolled in the Mothers and Children’s Environmental Health (MOCEH) study.ResultsThe multivariable regression model showed a significant reduction in birth weight associated with higher consumption level of foods rich in PAH, such as grilled or roasted meat, during pregnancy (β=−17·48 g, P<0·05 for every 1 point higher in meat score). Further adjusting for biomarkers of airborne PAH did not alter this association. There was no evidence that higher consumption level of PAH-rich meat shortens the duration of gestation (P=0·561). Regression models performed for birth length and head circumference produced negative effects that were not statistically significant.ConclusionsConsumption of higher levels of barbecued, fried, roasted and smoked meats during pregnancy was associated with reduced birth weight. Dietary risk of PAH exposure in Korean women is of concern.
‘How many calories did I just eat?’ An experimental study examining the effect of changes to serving size information on nutrition labels
Authors: Jones Amanda C , Vanderlee Lana , White Christine M , Hobin Erin P , Bordes Isabelle , Hammond David 
Published: April 2016

AbstractObjectiveTo test modifications to nutrition label serving size information on understanding of energy (calorie) content among youth and young adults.DesignParticipants completed two online experiments. First, participants were randomly assigned to view a beverage nutrition label with a reference amount of per serving (250 ml), per container (473 ml) or a dual-column format with both reference amounts. Participants were then randomized to view a cracker nutrition label which specified a single serving in small font, a single serving in large font, or the number of servings per bag with single serving information below. In both experiments, participants estimated energy content. Logistic regression analysis modelled correct energy estimation. Finally, participants reported their preference for serving size display format.SettingCanada.SubjectsCanadian youth and young adults (n2008; aged 16–24 years).ResultsIn experiment 1, participants randomized to view the nutrition label with per container or dual column were more likely to correctly identify energy content than those using per serving information (P<0·01). For experiment 2, the serving size display format had no association with correct energy estimation. The majority of participants (61·9 %) preferred the serving size format that included servings per package.ConclusionsLabelling foods with nutrition information using a serving size reference amount for the entire container increased understanding of energy content. Consumers prefer nutrition labels that include more prominently featured serving size information. Additional modifications that further improve consumers’ accuracy should be examined. These results have direct implications for nutrition labelling policy.
Preparation and Analysis of Atom Probe Tips by Xenon Focused Ion Beam Milling
Authors: Estivill Robert , Audoit Guillaume , Barnes Jean-Paul , Grenier Adeline , Blavette Didier 
Published: April 2016

AbstractThe damage and ion distribution induced in Si by an inductively coupled plasma Xe focused ion beam was investigated by atom probe tomography. By using predefined patterns it was possible to prepare the atom probe tips with a sub 50 nm end radius in the ion beam microscope. The atom probe reconstruction shows good agreement with simulated implantation profiles and interplanar distances extracted from spatial distribution maps. The elemental profiles of O and C indicate co-implantation during the milling process. The presence of small disc-shaped Xe clusters are also found in the three-dimensional reconstruction. These are attributed to the presence of Xe nanocrystals or bubbles that open during the evaporation process. The expected accumulated dose points to a loss of >95% of the Xe during analysis, which escapes undetected.
Shifting Frames
Authors: Feinholdt Alina , Schuck Andreas R. T. , Lecheler Sophie K. , de Vreese Claes H. 
Published: April 2016

Abstract. Prior research has found that exposure to news frames can cause emotional responses to political issues. Yet, little is known about how different combinations of news frames and issues relate to discrete emotions and whether these emotions, in turn, affect issue perceptions. The present study investigates these questions by testing whether (a) the effects of news articles, featuring highly versus moderately contested policy issues on perceived policy effectiveness (PPE), are mediated by three discrete emotions (anger, fear, and hope) and (b) if these effects depend on the type of generic news frame used (human interest vs. economic consequences). An online experimental survey (N = 405) demonstrated that the effects of issue contestation on PPE were mediated by hope and anger, but not by fear. These effects were only apparent within a human interest frame. The theoretical and practical implications of these results are discussed.
Imagine All the Forces
Authors: Gebauer Fabian , Raab Marius H. , Carbon Claus-Christian 
Published: April 2016

Abstract. A world divided into East versus West: The so-called Ukraine crisis has once more summoned outdated patterns of political thinking. Simultaneously, media discourses have flared up debating diplomatic and military solutions as possible policy responses. A majority of Germans, however, have remained hesitant to advocate any escalation of military conflict. We were interested in how far reputable journalism concerning the Ukraine crisis might activate a disposition toward military engagement. To evaluate the supposed impact of actual news coverage, we used explicit existential threats (mortality salience; MS) as a comparative measure. Typical effects of MS were derived from terror management theory (TMT), which predicts that the awareness of existential threats amplifies the efforts to defend one’s own culture, even by military means. We used a 2 × 2 factorial design (N = 112) with the factors article (original bellicose vs. neutral, nonmilitant depiction) and salience condition (MS vs. control). Results revealed a strong impact of the original, bellicose article, with increased willingness to deploy German forces at the Russian border, independently of the salience condition. Additional existential threats did not add further effects, as values for willingness were already very high. Classic effects regarding TMT were observed when people had read the Non-Militant article. Here, the willingness to deploy forces only increased after a confrontation with existential threats. We conclude that threatening news coverage on the Ukraine crisis has the ability to alter willingness for first-step military action at the Russian border by inducing effects that are – at least in their outcome – comparable to explicit existential threats.
Carfilzomib alters the HLA-presented peptidome of myeloma cells and impairs presentation of peptides with aromatic C-termini
Authors: Kowalewski D J , Walz S , Backert L , Schuster H , Kohlbacher O , Weisel K , Rittig S M , Kanz L , Salih H R , Rammensee H-G , Stevanović S , Stickel J S 
Published: April 2016

AbstractRecent studies suggest that multiple myeloma is an immunogenic disease, which might be effectively targeted by antigen-specific T-cell immunotherapy. As standard of care in myeloma includes proteasome inhibitor therapy, it is of great importance to characterize the effects of this treatment on HLA-restricted antigen presentation and implement only robustly presented targets for immunotherapeutic intervention. Here, we present a study that longitudinally and semi-quantitatively maps the effects of the proteasome inhibitor carfilzomib on HLA-restricted antigen presentation. The relative presentation levels of 4780 different HLA ligands were quantified in an in vitro model employing carfilzomib treatment of MM.1S and U266 myeloma cells, which revealed significant modulation of a substantial fraction of the HLA-presented peptidome. Strikingly, we detected selective down-modulation of HLA ligands with aromatic C-terminal anchor amino acids. This particularly manifested as a marked reduction in the presentation of HLA ligands through the HLA allotypes A*23:01 and A*24:02 on MM.1S cells. These findings implicate that carfilzomib mediates a direct, peptide motif-specific inhibitory effect on HLA ligand processing and presentation. As a substantial proportion of HLA allotypes present peptides with aromatic C-termini, our results may have broad implications for the implementation of antigen-specific treatment approaches in patients undergoing carfilzomib treatment.
Interactions between growth-dependent changes in cell size, nutrient supply and cellular elemental stoichiometry of marine Synechococcus
Authors: Garcia Nathan S , Bonachela Juan A , Martiny Adam C 
Published: April 2016

Abstract
The factors that control elemental ratios within phytoplankton, like carbon:nitrogen:phosphorus (C:N:P), are key to biogeochemical cycles. Previous studies have identified relationships between nutrient-limited growth and elemental ratios in large eukaryotes, but little is known about these interactions in small marine phytoplankton like the globally important Cyanobacteria. To improve our understanding of these interactions in picophytoplankton, we asked how cellular elemental stoichiometry varies as a function of steady-state, N- and P-limited growth in laboratory chemostat cultures of Synechococcus WH8102. By combining empirical data and theoretical modeling, we identified a previously unrecognized factor (growth-dependent variability in cell size) that controls the relationship between nutrient-limited growth and cellular elemental stoichiometry. To predict the cellular elemental stoichiometry of phytoplankton, previous theoretical models rely on the traditional Droop model, which purports that the acquisition of a single limiting nutrient suffices to explain the relationship between a cellular nutrient quota and growth rate. Our study, however, indicates that growth-dependent changes in cell size have an important role in regulating cell nutrient quotas. This key ingredient, along with nutrient-uptake protein regulation, enables our model to predict the cellular elemental stoichiometry of Synechococcus across a range of nutrient-limited conditions. Our analysis also adds to the growth rate hypothesis, suggesting that P-rich biomolecules other than nucleic acids are important drivers of stoichiometric variability in Synechococcus. Lastly, by comparing our data with field observations, our study has important ecological relevance as it provides a framework for understanding and predicting elemental ratios in ocean regions where small phytoplankton like Synechococcus dominates.