bluuebunny/crossref_metadata_2025_split huggingface dataset:
RT-PPS: Real-time privacy-preserving scheme for cloud-hosted IoT data
Authors: Elhoseny Mohamed , Riad Khaled 
Published: September 2024

The Internet of Things (IoT) is a rapidly growing network of devices that can communicate with each other and with cloud-based services. These devices generate vast amounts of data that can be used to provide valuable insights into user behavior, environmental conditions, and other important factors. However, as this data is collected and processed by cloud-hosted services, there is a growing concern about privacy and security. Without adequate protection, sensitive information could be exposed to hackers or other malicious actors, putting both individuals and organizations at risk. To address this challenge, real-time privacy-preserving techniques can be used to protect IoT data without compromising its value. This paper introduces an efficient Real-time privacy-preserving scheme (RT-PPS) for cloud-hosted IoT data. RT-PPS employs multi-authority attribute-based encryption on a hybrid cloud environment to keep data secure and private, while still allowing it to be processed and analyzed by cloud-hosted services. RT-PPS has efficient response time and resource consumption, which gives it the ability to handle a huge number of concurrent users at the same time without notable delay. The proposed RT-PPS has been validated through extensive experimental evaluation on a variety of configurations. Moreover, the proposed scheme has been computationally compared with the state-of-the-artwork. RT-PPS has shown excellent performance, effectiveness, and efficiency. The RT-PPS encryption time for a 1 GB dataset while considering 1024 slices is approximately 1000 ms. Also, the RT-PPS decryption time for a 1 GB ciphertext while considering 1024 slices are approximately 235 ms. Finally, RT-PPS is proven secure against any polynomial-time attacks and their variations that have at most a negligible advantage in the introduced security model. Moreover compared to most of the state-of-the-artwork, RT-PPS reduced the ciphertext size and lowered the computations in the encryption, key generation, decryption, and ciphertext update while assuring their security. By implementing RT-PPS, organizations can take advantage of the benefits of IoT data while protecting the privacy of their users and maintaining the security of their systems.
Investigation of the tolerability and potential health benefits of a novel butyrate generating supplement in a pilot human study
Authors: Smith Morganne , Lelah Michael , Goggans Mallory , Tunio Sameer , Naqib Ankur , Burton-Freeman Britt , Edirisinghe Indika 
Published: September 2024

BACKGROUND: Butyrate is a health promoting short-chain fatty acid (SCFA) metabolite of fiber fermentation in the gut. Supplementing directly with a butyrate generator may be a dietary alternative with health benefits. OBJECTIVE: To evaluate the effect of tributyrin, a butyrate generator, on tolerability, gut microbiome composition, gut permeability, inflammation and metabolic markers in healthy adults at two dose levels. METHODS: Healthy adults ( n = 29) were randomized to this single-blinded, two-arm, 28-day parallel design pilot study. Participants ingested one or two placebo capsules for 7 days followed by one or two (200 or 400 mg, respectively) ButyraGen® capsules, a novel tributyrin complex, daily for 21 days. Tolerability was assessed weekly by questionnaire. Blood and stool were collected at baseline and weekly for metabolic and inflammation markers, gut microbiome composition and SCFA concentrations, respectively. Urine was collected at baseline and end of the study for permeability assays. RESULTS: Twenty-four participants ( n = 24, 25±8 years; 24.0±2.8 kg/m2; 66% male) completed the study. ButyraGen® was well-tolerated, with less than 10% ( n = 2) reporting gastrointestinal-related discomfort. Fecal acetic ( p = 0.03) and propionic ( p = 0.03) acids decreased after supplementation ( p = 0.03 and p = 0.03, respectively, n = 24) compared to baseline, and triglycerides increased ( p = 0.02, 400 mg only, n = 11). Trends in decreased hs-CRP after 200 mg ( p = 0.08) and 400 mg ( p = 0.07) supplementation and decreased glucose ( p = 0.10) after 200 mg supplementation was observed. No other changes in endpoints were observed. CONCLUSIONS: Tributyrin supplementation using ButyraGen® was safe and tolerable at the doses provided. Biological effects were observed suggesting butyrate generation and absorption in the small intestine followed by activity in the liver, though further investigation on mechanism of action is needed for confirmation.
Validation of endoplasmic reticulum stress-related gene signature to predict prognosis and immune landscape of patients with non-small cell lung cancer
Authors: Cui Yingying , Zhou Xiaoli , Zheng Dan , Zhu Yumei 
Published: September 2024

BACKGROUND: Lung cancer is one of the most common cancers worldwide, with the incidence increasing each year. It is crucial to improve the prognosis of patients who have lung cancer. Non-Small Cell Lung Cancer (NSCLC) accounts for the majority of lung cancer. Though its prognostic significance in NSCLC has not been often documented, Endoplasmic Reticulum (ER) stress has been identified to be implicated in tumour malignant behaviours and resistance to treatment. OBJECTIVE: This work aimed to develop a gene profile linked to ER stress that could be applied to predictive and risk assessment for non-small cell lung cancer. METHODS: Data from 1014 NSCLC patients were sourced from The Cancer Genome Atlas (TCGA) database, integrating clinical and Ribonucleic Acid (RNA) information. Diverse analytical techniques were utilized to identify ERS-associated genes associated with patients’ prognoses. These techniques included Kaplan-Meier analysis, univariate Cox regression, Least Absolute Shrinkage and Selection Operator regression analysis (LASSO) regression, and Pearson correlation analysis. Using a risk score model obtained from multivariate Cox analysis, a nomogram was created and validated to classify patients into high- and low-risk groups. The study employed the CIBERSORT algorithm and Single-Sample Gene Set Eenrichment Analysis (ssGSEA) to investigate the tumour immune microenvironment. We used the Genomics of Drug Sensitivity in Cancer (GDSC) database and R tools to identify medicines that could be responsive. RESULTS: Four genes – FABP5, C5AR1, CTSL, and LTA4H – were chosen to create the risk model. Overall Survival (OS) was considerably lower ([Formula: see text] 0.05) in the high-risk group. When it came to predictive accuracy, the risk model outperformed clinical considerations. Several medication types that are sensitive to high-risk groups were chosen. CONCLUSION: Our study has produced a gene signature associated with ER stress that may be employed to forecast the prognosis and therapeutic response of non-small cell lung cancer patients.
SISTEM STRUKTUR BANGUNAN ARSITEKTUR JAWA JOGLO DAN TAJUG DALAM ADAPTASI TERHADAP GEMPA
Authors: Kusyanto Mohhamad , Koesmartadi Cristophorus 
Published: September 2024

Bentuk pokok bangunan tradisional Jawa Joglo dan Tajug hampir sama hanya berbeda pada bentuk atapnya. Sistem struktur kedua bangunan dalam beberapa penelitian mampu beradaptasi aman terhadap gempa. Namun bangunan atap tajug telah mengalami morfologi dan perubahan fungsi, dimensi dan performa bangunan diakibatkan penambahan jumlah jamaah sehingga mempengaruhi adaptasi terhadap gempa. Penelitian ini bertujuan untuk membandingkan sistem struktur bangunan tradisional Jawa Joglo dan Tajug dalam adaptasinya terhadap gempa. Penelitian ini menggunakan metode deskriptif kualitatif. Guna memperoleh gambaran maka analisis yang digunakan adalah analisis studi perbandingan sistem struktur kedua bangunan tersebut. Kasus yang menjadi amatan adalah bangunan arsitektur Jawa Joglo dan Tajug yang mengalami kerusakan dalam gempa di Indonesia. Temuan yang didapatkan perubahan morfologi, bentuk dan material bangunan arsitektur Jawa Tajug dengan pondasi jepit maka bangunan tidak rawan terhadap gempa. Sementara bangunan Joglo yang masih mempertahankan bentuknya dengan material menggunakan kayu menyebabkan bangunan ini aman saat terjadi gempa.
KESINAMBUNGAN BENTUK ORNAMEN PADA MASJID LANGGAR DALEM, LANGGAR BUBRAH, DAN MASJID MENARA KUDUS JAWA TENGAH
Authors: Hermanto Heri 
Published: September 2024

Sejak abad 8 sampai dengan 10 M kota Kudus diduga menjadi pusat pengembangan Agama Hindu dan Budha. Kyai Telingsing, Sunan Kudus, dan Sunan Muria merupakan tokoh yang sangat berjasa atas keberhasilan dakwah di Kudus. Metoda dakwah dengan pendekatan kultural, sikap toleran dan menghargai budaya Hindu-Budha menjadi salah satu penyebab keberhasilannya.
Di Kudus ditemukan 3 buah masjid kuno yang memperlihatkan kesinambungan bentuk ornamen yang berasal dari Hindu, Budha dan Islam. Ke-tiga masjid kuno itu adalah; Langgar Dalem (1480 M), Langgar Bubrah (1533M), Masjid Menara Kudus (1549 M). Penelitian tentang Masjid Menara Kudus sudah banyak dilakukan, tetapi penelitian tentang kesinambungan bentuk ornamen diantara masjid masjid kuno tersebut belum pernah diteliti secara komprehensif.
Sehingga tujuan dari penelitian ini adalah; 1) Menemukan kesinambungan bentuk ornamen arsitektur pada masjid-masjid kuno di Kudus, 2) serta konsep apakah yang mendasari bentuk ornamen pada masjid-masjid kuno di Kudus. Penelitian ini menggunakan metode penelitian kualitatif deskriptif, dengan cara observasi, perekaman data, dan menggali dari sumber primer historiografi. Hasil penelitian menemukan bahwa kesinambungan bentuk ornamen arabesque yang bercorak Islam pada masjid Langgar Dalem, Langgar Bubrah, dan Menara Kudus. Adapun konsep yang mendasari bentuk ornamen adalah lafal Allah, Muhammad, dan La ilaha illallah
Alterations in novel inflammatory biomarkers during perioperative cardiovascular surgeries involving cardiopulmonary bypass: a retrospective propensity score matching study
Authors: Zhou Wei , Wang He , Li Chen , Ma Qi-min , Gu Yan-hui , Sheng Shu-yue , Ma Shao-lin , Zhu Feng 
Published: September 2024

BackgroundCardiopulmonary bypass (CPB) triggers a strong inflammatory response in cardiovascular surgery patients during the perioperative period. This article mainly focuses on the perioperative application of novel inflammatory biomarkers in cardiovascular surgeries involving CPB.MethodsPatients were divided into a CPB group and a non-CPB group according to whether they underwent CPB during cardiovascular surgery. Novel inflammatory biomarkers and clinical results were recorded. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), platelet × neutrophil/lymphocyte ratio (SII), and monocyte × platelet × neutrophil/lymphocyte ratio (PIV) were calculated. The primary outcomes were perioperative prognosis between the CPB and non-CPB groups. The secondary outcomes included perioperative alterations of novel inflammatory biomarkers in the CPB group and predictive values of novel inflammatory biomarkers for postoperative infection and acute kidney injury.ResultsA total of 332 patients were initially included in the study. Before propensity score matching (PSM), there were 96 patients in the CPB group and 236 patients in the non-CPB group. After PSM, both groups included 58 patients each. Compared with the non-CPB group, the CPB group had a higher proportion of intraoperative transfusion of blood products (63.79% vs. 6.90%, P &lt; 0.001), specifically for red blood cells (58.62% vs. 3.45%, P &lt; 0.001) and plasma (41.38% vs. 1.72, P &lt; 0.001), exhibited a higher drainage fluid volume within 24 h [380 (200–550) ml vs. 200 (24–330) ml, P = 0.002], and required longer durations of mechanical ventilation [14.3 (6.6–21.3) h vs. 5.75 (4.08–10.1) h, P &lt; 0.001] and ICU stay [48.78 (44.92–89.38) h vs. 27.16 (21.67–46.25) h, P &lt; 0.001]. After surgery, NLR [14.00 (9.93–23.08) vs. 11.55 (7.38–17.38), P = 0.043] was higher in the CPB group, while the PIV, PLR, and SII in the CPB group were lower than those in the non-CPB group on the first day after surgery.ConclusionsCardiovascular surgeries involving CPB exhibit a poorer prognosis compared to non-CPB procedures. Novel inflammatory biomarkers, including PLR, PIV, and SII, may offer valuable insights into the degree of postoperative inflammation, with NLR emerging as a potentially reliable prognostic indicator.
Lipocalin-2 drives neuropsychiatric and cutaneous disease in MRL/lpr mice
Authors: Garcia Sayra J. , Mike Elise V. , Zhang Jinghang , Cuda Carla M. , Putterman Chaim 
Published: September 2024

IntroductionApproximately 20-40% of patients with systemic lupus erythematosus (SLE) experience neuropsychiatric SLE (NPSLE), which often manifests as cognitive dysfunction and depression. Currently, there are no approved treatments for NPSLE because its underlying mechanisms are unclear. Identifying relevant mediators and understanding their contribution to pathogenesis are crucial for developing targeted treatment options. Lipocalin 2 (LCN2) is a multifunctional acute-phase protein that plays important roles in immune cell differentiation, migration, and function. LCN2 has been implicated in models of neuroinflammatory disease.MethodsWe generated an LCN2-deficient MRL/lpr mouse to evaluate the effects of LCN2 on this classic NPSLE model. To evaluate the effects of LCN2 deficiency on behavior, the mice underwent a battery of behavioral tests evaluating depression, memory, and anxiety. Flow cytometry was used to quantify immune cell populations in the brain, blood, and secondary lymphoid organs. Cutaneous disease was quantified by scoring lesional skin, and skin infiltrates were quantified through immunofluorescent staining. Systemic disease was evaluated through measuring anti-nuclear antibodies by ELISA.ResultsIn this study, we found that LCN2 deficiency significantly attenuates neuropsychiatric and cutaneous disease in MRL/lpr lupus prone mice, likely by decreasing local infiltration of immune cells into the brain and skin and reducing astrocyte activation in the hippocampus. Anti-nuclear antibodies and kidney disease were not affected by LCN2.DiscussionAs there was no effect on systemic disease, our results suggest that the inflammatory effects of LCN2 were localized to the skin and brain in this model. This study further establishes LCN2 as a potential target to ameliorate organ injury in SLE, including neuropsychiatric and cutaneous disease.
Exploring the relationship between ultrasound parameters and muscle strength in older adults: a meta-analysis of sarcopenia-related exercise performance
Authors: Yuan Han , Kim Maeng-Kyu 
Published: September 2024

IntroductionUltrasound (US) imaging has emerged as a promising tool for assessing age-related muscle changes. This meta-analysis aimed to comprehensively evaluate the associations between US parameters and muscle strength, as well as sarcopenia-related functional performance in older adults by integrating data from multiple studies.MethodsA systematic literature search was conducted in PubMed, Web of Science, and Embase until June 2023. Studies reporting Pearson’s correlation coefficients between US parameters [echo intensity (EI), muscle thickness (MT), cross-sectional area (CSA), pinnations angle (PA), fascicle length (FL)] and measures of muscle strength or physical performance in older adults were included. Effect sizes were pooled using a random-effects model and presented in forest plots. Heterogeneity was assessed using I2, and publication bias was evaluated using Egger’s test.ResultsTwenty-eight studies met the inclusion criteria. Meta-analysis revealed moderate to strong correlations between EI, MT, and CSA with muscle strength. However, no significant associations were found between US parameters and gait speed. For chair stand tests, the strength of associations varied by test type, with weak correlations observed between echo intensity and muscle thickness with sit-to-stand tests. US parameters did not exhibit significant correlations with the Timed Up and Go test.ConclusionUltrasonographic measurements of echo intensity (EI) and muscle thickness (MT) demonstrated moderate to strong correlations with muscle strength and functional assessments related to sarcopenia. To enhance the accuracy of sarcopenia diagnosis and the effectiveness of management strategies, there is a need for larger, longitudinal studies that evaluate a comprehensive range of ultrasonographic parameters.Systematic review registrationhttps://inplasy.com, identifier INPLASY202410086.
Prevalence of single-nucleotide variants in twenty-five pharmacogenes from a Cuban sample cohort
Authors: Reyes-Reyes Elizabeth , Herrera-Isidrón José Alfredo , Cuétara-Lugo Elizabeth , Shkedy Zhiv , Valkenborg Dirk , Pérez-Novo Claudina Angela , Fernández-Peña Gisselle , González-Pérez Idania , Fernández-Pérez Miguel David , Vanden-Berghe Wim , Rodeiro-Guerra Idania 
Published: September 2024

IntroductionThe Cuban population is genetically diverse, and information on the prevalence of genetic variants is still limited. As complex admixture processes have occurred, we hypothesized that the frequency of pharmacogenetic variants and drug responses may vary within the country. The aims of the study were to describe the frequency distribution of 43 single-nucleotide variants (SNVs) from 25 genes of pharmacogenetic interest within the Cuba population and in relation to other populations, while taking into consideration some descriptive variables such as place of birth and skin color.Materials and MethodsSNVs were analyzed in 357 unrelated healthy Cuban volunteers. Genotype, allele frequencies, and ancestry proportions were determined, and the pairwise fixation index (FST ) was evaluated.ResultsHardy–Weinberg equilibrium (HWE) deviations in six loci (rs11572103, rs2740574, rs776746, rs3025039, rs861539, and rs1762429) were identified. Minor allele frequencies (MAFs) ranged from 0.00 to 0.15 for variants in genes encoding xenobiotic metabolizing enzymes. They also ranged from 0.01 to 0.21 for variants in DNA repair, growth factors, methyltransferase, and methyl-binding proteins, while they ranged from 0.04 to 0.27 for variants in the O-6-methylguanine-DNA methyltransferase enzyme. Moderate genetic divergence was observed upon comparison to Africans (FST = 0.071 and SD 0.079), with 19 markers exhibiting moderate-to-large genetic differentiation. The average European, African, and Amerindian ancestry proportions were 67.8%, 27.2%, and 5.3%, respectively. Ancestry proportions differed by skin color and birthplace for both African and European components, with the exception of the European component, which showed no significant difference between individuals from Western and Eastern regions. Meanwhile, the statistical significance varied in comparisons by skin color and birthplace within the Amerindian component. Low genetic divergence was observed across geographical regions. We identified 12 variants showing moderate-to-large differentiation between White/Black individuals.ConclusionAltogether, our results may support national strategies for the introduction of pharmacogenetic tools in clinical practice, contributing to the development of precision medicine in Cuba.
The doctor will not see you now: investigating the social determinants of specialist care using the Canadian Longitudinal Study on Aging (CLSA)
Authors: Lan Marie , Alemu Feben W. , Ali Shehzad 
Published: September 2024

BackgroundThe Canada Health Act mandates universal access to medical services for all Canadians. Despite this, there are significant disparities in access based on socioeconomic status, race and ethnicity, immigrant status, and indigeneity. However, there is limited evidence on the use of specialist services among older adults in Canada. The primary objective of this study is to identify the associations of social determinants of health with access to medical specialist services for Canadians aged 45 years and older. The second objective is to identify the reasons for not being able to access the needed specialist care.MethodsA cross-sectional analysis of the Canadian Longitudinal Study on Aging survey was conducted. Based on the Andersen’s model of health services use, a multivariable logistic regression model was used to evaluate the associations between ‘not being able to access the needed specialist service(s) in the last 12 months’ and individual-level sociodemographic determinants.ResultsApproximately 97% of those who required specialist care in the last year were able to visit a specialist. Of the participants who were not able to access the needed specialist services, about half (50.90%) were still waiting for a visit. The following factors were associated with greater difficulty in accessing specialist care: being younger (45-54 years), living in a rural area, having some post-secondary education, having a household income below $50,000 a year, not having a family physician, and having fair or poor perceived general health. Residents of British Columbia and Nova Scotia had a higher likelihood of reporting difficulty compared to those residing in Ontario.ConclusionWhile a majority of respondents were able to access specialist services when needed, those who had difficulty in accessing care were more likely to come from socially marginalized groups. Targeted policy interventions and improved health system coordination can reduce these barriers to care.
Evaluating hand hygiene knowledge, attitudes, and practices among healthcare workers in post-pandemic H1N1 influenza control: a cross-sectional study from China
Authors: Hong Qin , Xu Yuling 
Published: September 2024

BackgroundThis study evaluates the knowledge, attitudes, and practices (KAP) of hand hygiene among healthcare workers, crucial for preventing healthcare-associated infections (HAIs) in medical facilities.MethodologyThis cross-sectional study assessed hand hygiene KAP among healthcare workers across various settings in Hubei, China utilizing a stratified random sampling approach from, December 25, 2023-to-April 25, 2024. A bilingual electronic survey, adapted from validated tools, was disseminated via email and social media to ensure a broad reach. Participants included diverse healthcare professionals who met specific inclusion criteria. Responses were analyzed using R software, employing descriptive and inferential statistics to identify key predictors of hand hygiene behavior and to confirm the reliability of the survey instrument.ResultsThe survey of 2,265 healthcare workers revealed that 77% demonstrated comprehensive knowledge of hand hygiene, 80% exhibited positive attitudes, and 94% practiced effective hand hygiene. Notable findings include a significant understanding of hand hygiene’s role in preventing respiratory illnesses (58%) and HAIs (41% agreed, 39% unsure). High compliance in practices like washing hands for at least 20 s was evident (84%), though gaps in confidence about hand hygiene techniques were noted (33% confident, 56% unsure). Binary logistic regression analysis indicated that younger healthcare workers (21–30 years) were more likely to exhibit both knowledge (OR = 7.4, 95% CI = 1.44–136, p = 0.059) and positive attitudes (OR = 4.48, 95% CI = 1.73–11.8, p &lt; 0.001) compared to other age groups. Significant associations were found between higher income levels and positive attitudes toward hand hygiene (OR for ≥80,000 = 3.19, 95% CI = 2.05–5.02, p &lt; 0.001), and between knowledge and practices, suggesting that well-informed individuals are more likely to adhere to recommended practices.ConclusionThe findings reveal robust hand hygiene knowledge but uncover critical confidence gaps among healthcare workers, urging immediate, targeted educational interventions to fortify adherence and prevent infection outbreaks.