bluuebunny/crossref_metadata_2025_split huggingface dataset:
Studies on Formulation and Evaluation of Ethyl Cellulose Based Extended Release Metformin Hydrochloride Matrix Tablets
Authors: Kaliyan Sundaramoorthy 
Published: April 2017

Monolithic matrix tablets of metformin hydrochloride were formulated as extended release tablets by employing ethyl cellulose polymer and the extended release characterization of the formulated tablets was investigated. Extended release matrix tablets containing 500 mg metformin hydrochloride were developed by changing concentration of drug : polymer (EC) in the ratio of 5:1, 5:2, 5:3 and 5:4 by direct compression. Formulations were optimized based on the acceptable tablet properties invitro and invivo drug release. The resulting formulations produced robust tablets with optimum hardness, weight variation, drug content and low friability. The result of invitro and invivo drug release studies indicated that formulation (drug:polymer =5:3), is the most successful of the study and exhibited constant and extended release of metformin hydrochloride 99-100.5% release at the end of 10 h compared with reference standard. Further, the formulation F3 was subjected to exposure at room and accelerated condition to stability studies. A decrease in release of the drug was observed on increasing polymer ratio at certain level. Before tablet compression, the resulting formulation blends were evaluated for angle of repose, bulk density, % porosity, % compressibility index and drug polymer compatibility study of drug and excipients. The t25, t50 and t90 drug release values was calculated from selected formulation F3 on every month of stability studies and comparision of both room and accelerated condition by statistical t-test, there is no difference between storage temperature. The formulation F3 was showed similar invitro and invivo drug release when compared to marketed sustained release tablet (F5M).
SEPARATION AND DETERMINATION OF THE R-ISOMER OF ETODOLAC IN A BULK DRUG SUBSTANCE BY NORMAL-PHASE LIQUID CHROMATOGRAPHY
Authors: Lawande Appasaheb Bajirao 
Published: April 2017

ABSTRACT Objective: The objective of the this work is to develop and validate a novel, simple,rapid and reliable analytical method for separation and determination of R-isomer impurity in Etodolac bulk drug material by normal-phase high-performance liquid chromatography as per International Conference on Harmonization guidelines. Methods: The Etodolac R- isomer and S-isomer were separated on a Chiralcel OD-H (150 x 4.0 mm, 5 micron) column by using Ethanol : n-Hexane:Trifluoroacetic acid (50:50:0.1 v/v.) mobile phase with equipped detector at wavelength 225 nm and 25 °C column oven temperature. The resolution between R-isomer and S-isomer were more than two recorded on chromatogram. The specified method was developed and validated for various parameters like reproducibility, limit of detection, limit of quantification, linearity and range, robustness, solution stability and mobile phase stability according to the International Conference on Harmonization (ICH) guidelines. Results: Linearity were found for Etodolac R-isomer over the concentration range of 600–6000 ng/ml, with the linear regression (Correlation coefficient R = 0.998) and proved to be robust. Limit of detection and limit of quantification of Etodolac R-isomer was found to be 200 and 600 ng/ml. The retention time of R-isomer was considered to be 2.8 min. The percentage recovery of Etodolac R-isomer has been ranged from 97.0 to 102.0 in bulk drug material sample. The proposed analytical method has been found to be suitable, precise,reliable and accurate for the separation and quantitative determination of Etodolac R-isomer in bulk drug sample. Conclusion: A novel, speedy, accurate, precise, reliable and rugged analytical method has been developed and validated for normal phase high performance liquid chromatography to determine R-isomer impurity in Etodolac bulk drugs material as per ICH guideline. Keywords: Etodolac, HPLC, Known Impurity. Normal Phase, Validation.
ASSESSMENT OF LEFT ATRIAL FUNCTION IN PATIENTS WITHMITRAL VALVE DISEASES
Authors: N Karthikrao 
Published: April 2017

ABSTRACTObjective:To observe and assess left atrial (LA) function by observing the differences in conventional Doppler echo parameters of left ventricular inflow, Left atrial appendage, among patients with mitral valve disease.Methods: Forty three mitral valve disease subjects appearing consecutively for echocardiogram (ECHO) test at the cardiology department in a tertiary care hospital were recruited into the study as per the pre-set inclusion and exclusion criteria. The data from the ECHO was pooled using Microsoft excel and analyzed using SPSS software by application of appropriate statistical tests.Results:Of the 43 objects, 39 had MS, 3 had MR and 2 of them were found to have both MS and MR. The major presenting symptom as observed in 33 subjects, was dyspnea. LA maximum volume was found to be 91±59 ml and minimum was 66±51 ml. Left atrial expansion index was 128±91. Left atrial active emptying fraction was 29±13 and passive emptying fraction was 31±15. No significant change in LA global strain among groups with MR and without MR was observed. Further, no significant difference was observed in left atrial indices like left atrial emptying fraction, left atrial passive emptying fraction, atrial fraction, Left atrial expansion index among groups having MR and no MR.Conclusion:LA contractile, reservoir and conduit function was significantly reduced in mitral valve diseases due to increased hemodynamic load. No significant difference was noted in global LA strain irrespective of MS or MR.Key Words: Valvular disease; Left atria; Strain; Contractile function
EXPERIMENTAL EVALUATION OF THE ANTI-ULCER ACTIVITY OF GRAPE (VITIS VINIFERA) SEED EXTRACT IN WISTAR ALBINO RATS AGAINST HYDROCHLORIC ACID – ETHANOL INDUCED ULCER MODEL
Authors: Ingale Anand M , Pinnelli Dr. Venkata Bharatkumar , Rajendran Dr. Vijaya 
Published: April 2017

Background:Herbal products are finding increasing demand in the treatment of Peptic ulcer, on account of their better safety and efficacy.Objectives:To evaluate the anti-ulcer activity of ethanolic extract of seeds of Vitis Vinifera in Wistar albino rats.Methods:The ethanolic extract of Vitis Vinifera was investigated for its anti-ulcer activity in rats against HCl – Ethanol induced ulcer model. The antiulcer activity was assessed by determining and comparing gastric volume, pH, free and total acidity; ulcer number and its inhibition, ulcer severity and ulcer index.Results:A significant antiulcer activity was observed. The grape seed 100mg/kg group showed significant [p < 0.05] reduction in ulcer number 30.00 ± 3.23 as compared to the control. The grape seed 200mg/kg showed significant [p < 0.05] reduction in ulcer number 27.33 ± 2.97, free acidity 20.00 ± 2.26, and gastric lesion18.00 ± 2.96 as compared to the control.Conclusion:This present study indicates that Vitis vinifera seed extract has potential anti ulcer activity in the model tested. Keywords: Vitis vinifera, Anti-ulcer, Ethanol, Free acidity, Total acidity
ISOLATION AND IDENTIFICATION OF BACTERIOCIN PRODUCING MICROBES USING BIOCHEMICAL AND MOLECULAR TOOLS AND ANALYSIS OF ITS BIOPRESERVATION POTENTIAL
Authors: Nandan Parmar Keshri , Nagar Anshita 
Published: April 2017

ABSTRACTObjective: Food safety is a matter of utmost importance in developing countries as well as in developed countries, so keeping this in mind this researchwork deals with the identification and characterization of bacteriocin producing microbes by using biochemical and molecular characterization. This study has also covered the biopreservation potential of bacteriocin produced by these microbes against sapodilla, tomato and banana as well.Methods: For the purpose of sample collection and isolation, samples of milk, curd and gangajal water were taken and bacteriocin producing microbes were isolated by using serial dilution method. Screening of bacteriocin producing microbe was done by antibacterial sensitivity test using agar well diffusion method against Bacillus amyloliquefaciens, Escherichia Coli, Staphylococcus aureus and Pseudomonas aeruginosa by determining their zone of inhibition. Biochemical characterization was done by using different tests, such as, catalase test, mannitol test, citrate test, gelatin test, maltose test, indole test, urease test, lactose test etc. Molecular characterization was done by using 16S rRNA gene sequencing. Preservative action of bacteriocinwas observed on fruits that comprise sapodilla, tomato and banana by spraying bacteriocin on them and analyzing their activities shows for at least10 days.Results: Microbes were found to be Enterococcus faecalis (Accession number KX011874) and Bacillus cereus (Accession number KX011875). Periodicobservatory studies reflect that using bacteriocin, banana can be preserved for nearly 6-7 days while sapodilla for 8-9 days and tomato for 9-10 days.Conclusion: From present study we would like to conclude that bacteriocins produced by microbes which is found in milk or curd can also be used asbiopreservatives for these defined fruits that is sapodilla, tomato and banana.Keywords: Bacteriocin, Biopreservation, 16S rRNA analysis.
ELECTROCHEMICAL OXIDATION AND DETERMINATION OF AN ANTI-CANCER DRUG PEMETREXED DISODIUM
Authors: Shetti Nagaraj P 
Published: April 2017

Abstract-The electrochemical oxidation of an anti-cancer drug Pemetrexed disodium has been investigated at glassy carbon electrode using voltammetric techniques. The dependence of current on potential, pH, concentrartion, scan rate, and excipients were investigated to optimize the experimental conditions. According to the liner relation between peak potential, peak current, scan rate and Pemetrexed disodium concentration, differential pulse voltammetric method for the quantitative determination in phosphate Buffer solution was developed. The linear response was obtained in the range of 10 µM to 0.75 µM with a detection limit of 0.19 µM. The electrochemical oxidation of mechanism of an anti-cancer drug Pemetrexed disodium was proposed. Keywords- Pemetrexed disodium, Cyclic Voltammetry, Electochemical Studies, Glassy carbon electrode
Cohesión y adaptabilidad familiar posterior a la infección por chikungunya
Authors: Zambrano Gualiche Pablo Fausto , Villagómez Vélez Karol Katherine , Yuquilema Cunalata Marco Eduardo , Viera Quishpe Diana Belén 
Published: April 2017

<p><strong>Resumen </strong></p><p><strong>Objetivos</strong></p><p>El presente estudio tiene la finalidad de establecer la cohesión y adaptabilidad familiar en pacientes que presentaron la infección de chikungunya, en el Nor-occidente de Pichincha Ecuador.</p><p><strong>Métodos</strong>: Se establece una muestra a conveniencia de la base de datos del sistema de vigilancia epidemiológica del Ministerio de Salud Pública del Ecuador, que cumplieron los criterios de inclusión, con la escala FACES III se establece la cohesión y adaptabilidad familiar</p><p><strong>Resultados</strong>: se contactó y visito a treinta persona de la zona del Nor-occidente de Pichincha de los cuales, ocho pertenecen al género masculino (26,7%) y veinte y dos al género femenino (73,3%). Se encontró once de las diez y seis familias del modelo circumplejo propuesto por Olson y sus colaboradores y de acuerdo a su tipología 27% de las familias se encontraron en rango medio, 33% extremas y un 40% fueron balanceadas</p><p><strong>Conclusiones</strong>: de acuerdo a cohesión el mayor porcentaje de las familias se encuentran desvinculadas (40%) y con una adaptabilidad caótica que podría suponer una dificultad al momento de afrontar las secuelas derivadas de la infección por virus de chikungunya.</p><p><strong>Palabras clave</strong>: chicungunya, cohesión y adaptabilidad familiar</p><p> </p><p> </p><p><strong>Summary</strong></p><p>The present study aims to establish family cohesion and adaptability in patients presenting with chikungunya infection in the Northwest of Pichincha Ecuador.</p><p><strong>Methods</strong>: A convenience sample of the database of the epidemiological surveillance system of the Ministry of Public Health of Ecuador, which fulfilled the inclusion criteria, was established with the FACES III scale establishing family cohesion and adaptability.</p><p><strong>Results</strong>: a thirty-person from the northwestern area of Pichincha was contacted and visited, of which eight belonged to the male gender (26.7%) and twenty-two the female gender (73.3%). It was found once of the sixteen families of the model proposed by Olson and his collaborators and according to their typology 27% of the families were in the middle range, 33% of extremes and 40% were balanced.</p><p><strong>Conclusions:</strong> according to the cohesion of the highest percentage of the families, they are unlinked (40%) and with a chaotic adaptability that represented a difficulty when facing the sequelae derived from infection with chikungunya virus.</p><p><strong>Keywords:</strong> chicungunya, family cohesion and adaptability.</p>
Inovative Design of Mattress by Using TRIZ and QFD
Authors: Soewardi Hartomo , Edhi Ginanjar Sarwo 
Published: April 2017

Abstract–At this time the need for the design of a product is increased. Mattress is a necessity for every individual to rest. Preliminary studies of the function of the mattress stated that the use of the existing mattress found complaints (too large 72%, less attractive 40%, 80% less flexible, less comfortable 40%). Therefore, multifunctional mattress is needed. The purpose of this study is to propose a multifunctional design for a mattress. TRIZ method is used to determine the inventive principles of each attribute and QFD method is used to determine the design parameters of the mattress. Functions that can be developed from a mattress are that it can be folded, it can be a sofa / seating, into the table, flexible /easily removable and as the ironing board. The results of this study shows that the multifunctional mattress design was satisfied the customer feeling and emotion. Keyword–Mattress, TRIZ, QFD, Multifaction, Design
A atuação do enfermeiro do trabalho na prevenção de riscos ergonômicos
Authors: Oliveira Pedrosa Islayne , Araújo Sobral Wglaison Paulo de , Espíndula Brasileiro Marislei 
Published: April 2017

Descrever a atuação do enfermeiro do trabalho na prevenção de riscos ergonômicos. É um estudo bibliográfico, exploratório e descritivo, com análise integrativa da literatura disponível nas bases de dados virtuais em saúde, Biblioteca Virtual de Saúde - Bireme e SciELO - Scientific Electronic Library Online. Foram selecionados 8 artigos científicos, durante os anos de 2010 e 2013, onde concordam que a atuação do enfermeiro do trabalho é essencial para a prevenção de riscos ergonômicos tais como: avaliar a comunidade, planejar as suas ações, suprir a falta de informações e condições de trabalho, ampliar seu papel, ampliar a saúde do trabalhador, ajudar na sua reabilitação em seu retorno ao trabalho reassumindo sua autonomia, atuando por uma coletividade, segurança, bem estar, e a qualidade de vida para todos, dentro ou fora das organizações, conscientizando da necessidade dos equipamentos de proteção individuais - EPI’s, atuar na prevenção primária com o intuito de evitar danos à saúde, adequação ergonômica, prevenindo dores posturais, principalmente as musculoesqueléticas, complicações físicas e mentais, fadigas e acidentes, adequadas condições de trabalho, conhecimento e avaliação de riscos ergonômicos, melhorar o conforto, melhor qualidade de vida e desempenho produtivo. Conclui-se que o enfermeiro do trabalho por meio de seus cuidados, é um profissional que faz a prevenção, redução e/ou eliminação dos riscos ergonômicos.
A educação ambiental na formação do enfermeiro: uma revisão
Authors: Aquino Horta Diego , Gargia Eça Marcela 
Published: April 2017

A ecologia trouxe o ensejo do desenvolvimento econômico e sustentável com o pensamento principal que o ambiente está diretamente ligado à forma como o homem se apropria dos recursos. A enfermagem tem como alicerce o cuidado e o bem-estar do indivíduo buscando o equilíbrio na promoção da saúde e no educar. Este projeto tem o objetivo de identificar, em literatura, a forma como o pensamento ecológico evoluiu e vem sendo abordado pela enfermagem no ensino da educação ambiental nas escolas. A metodologia científica adotada baseia-se na pesquisa bibliográfica do tipo revisão literária com recorte temporal de vinte anos - 1996 a 2016. Após a leitura criteriosa, duas categorias foram compostas: "Educação da Ecologia na Enfermagem" - evidenciando a formação do profissional de enfermagem no pensamento prático associando a saúde - e o "Meio Ambiente, e Ecologia na Pratica de Enfermagem" - que exibe o desenvolvimento da enfermagem na conscientização ao manejo de substâncias que possam agredir o ambiente. Diante do exposto, hiperativa-se o questionamento referente ao meio ambiente e ao desenvolvimento do pensamento crítico-reflexivo nos profissionais de enfermagem para a responsabilidade ambiental, propiciando mudanças sociais transformadoras e inserção do enfermeiro no entrelaçamento do cuidado do meio ambiente e do homem, interligando-os em uma harmonia mútua.
Assistência de enfermagem ao adulto com agravos respiratórios
Authors: Maia Luiz Faustino dos Santos , Laís dos Santos Barbara , Pereira Clene Maria de Jesus , Moura Santos Marcilene , Pereira Rodrigues Ediana , Conceição dos Santos Magda da 
Published: April 2017

O objetivo deste trabalho é descrever as principais ações de assistência de enfermagem diante de pacientes adultos com agravos respiratórios. Realizou-se um levantamento da produção científica relacionada à prática de enfermagem diante dos agravos respiratórios na base de dados eletrônicos SciELO e LILACS. Constatou-se que a pneumonia, a asma e gripe são os tipos de agravos respiratórios que acometem um grande número de indivíduos sendo consideradas entre as principais causas de internações. Neste contexto o profissional de enfermagem se depara frequentemente com pacientes com algum tipo de agravo respiratório. O estudo apontou que ele executa deste o apoio do paciente nos limites hospitalares e o desenvolvimento do diagnóstico de enfermagem e aplicação de prescrições de enfermagem até a realização de educação em saúde visando orientar a população a respeito da identificação de fatores agravantes e desencadeantes, dos sintomas característicos e melhorar-se aderência as diferentes formas de tratamento e controle.
2016 JOSPT Awards: Additive Effects and Biological Mechanisms of Interventions Offer Important Insights
Authors: Abbott J. Haxby 
Published: April 2017

During the American Physical Therapy Association's Combined Sections Meeting in San Antonio, TX in February 2017, JOSPT recognized the authors of the most outstanding research and clinical practice manuscripts published in JOSPT during 2016. The 2016 JOSPT Excellence in Research Award was presented to Carol A. Courtney, Alana D. Steffen, César Fernández-de-las-Peñas, John Kim, and Samuel J. Chmell, MD, for their March 2016 article “Joint Mobilization Enhances Mechanisms of Conditioned Pain Modulation in Individuals With Osteoarthritis of the Knee.” The 2016 George J. Davies-James A. Gould Excellence in Clinical Inquiry Award was presented to Seyda Toprak Celenay, Turkan Akbayrak, and Derya Ozer Kaya for their February 2016 article “A Comparison of the Effects of Stabilization Exercises Plus Manual Therapy to Those of Stabilization Exercises Alone in Patients With Nonspecific Mechanical Neck Pain: A Randomized Clinical Trial.” J Orthop Sports Phys Ther 2017;47(4):225–227. doi:10.2519/jospt.2017.0104
La traite des femmes dans le contexte des grands évènements sportifs : quel plan de match ?
Authors: Plouffe-Malette Kristine , Langlois Léa Lemay 
Published: April 2017

À chaque évènement sportif d'envergure internationale, Jeux olympiques, Coupe du monde, Super Bowls ou Grands Prix de Formule 1 confondus, l'hypothèse selon laquelle l'exploitation sexuelle, la prostitution et la traite des femmes augmentent refait surface. Si l'existence de ces phénomènes n'est plus à démontrer, leur augmentation lors de la tenue de grands évènements sportifs fait toujours l'objet de débats, et ce, essentiellement en raison d'une confusion sémantique. Cet article avance qu'il est impossible de conclure à une augmentation de la traite lors de ces évènements en raison, d'une part, des problèmes d'interprétation de la notion de traite des femmes, internationalement définie et trop souvent confondue avec celle de prostitution, lesquelles reposent sur des systèmes normatifs distincts. D'autre part, ces méconnaissances interprétatives entraînent des impairs méthodologiques illustrés par une revue des campagnes de lutte contre l'exploitation sexuelle lors des grands évènements sportifs. En conséquence, différents acteurs instrumentalisent le « mythe » de l'augmentation de la traite des femmes afin de faire avancer leurs agendas respectifs lors de ces évènements, et ce, au détriment de la protection des victimes de traite. Il s'agit ainsi d'analyser l'impact du droit, international et accessoirement national canadien, en matière de prostitution et de traite des femmes, en temps d'évènements sportifs d'envergure.
Vessel wall signal enhancement on 3-T MRI in acute stroke patients after stent retriever thrombectomy
Authors: Abraham Peter , Scott Pannell J. , Santiago-Dieppa David R. , Cheung Vincent , Steinberg Jeffrey , Wali Arvin , Gupta Mihir , Rennert Robert C. , Lee Roland R. , Khalessi Alexander A. 
Published: April 2017

OBJECTIVE
In vivo and in vitro studies have demonstrated histological evidence of iatrogenic endothelial injury after stent retriever thrombectomy. However, noncontrast vessel wall (VW)–MRI is insufficient to demonstrate vessel injury. Authors of this study prospectively evaluated iatrogenic endothelial damage after stent retriever thrombectomy in humans by utilizing high-resolution contrast-enhanced VW-MRI. Characterization of VW-MRI changes in vessels subject to mechanical injury from thrombectomy may allow better understanding of the biological effects of this intervention.

METHODS
The authors prospectively recruited 11 patients for this study. The treatment group included 6 postthrombectomy patients and the control group included 5 subjects undergoing MRI for nonvascular indications. All subjects were evaluated on a Signa HD× 3.0-T MRI scanner with an 8-channel head coil. Both pre- and postcontrast T1-weighted Cube VW images as well as MR angiograms were acquired. Sequences obtained for evaluation of the brain parenchyma included diffusion-weighted, gradient echo, and T2-FLAIR imaging. Two independent neuroradiologists, who were blinded to the treatment status of each patient, determined the presence of VW enhancement. Patient age, National Institutes of Health Stroke Scale score on presentation, location of occlusion, stroke etiology, type of device used, number of device deployments, Thrombolysis in Cerebral Infarction (TICI) reperfusion score, stroke volume, and 90-day modified Rankin Scale score were also noted.

RESULTS
Postcontrast T1-weighted VW enhancement was detected in the M2 segment in 100% of the thrombectomy patients, in the M1 segment in 83%, and in the internal carotid artery in 50%. One patient also demonstrated A1 segment enhancement, which was attributable to thrombectomy treatment of that vessel segment during the same procedure. None of the control patients demonstrated VW enhancement of their intracranial vasculature on T1-weighted images.

CONCLUSIONS
The study findings suggest that VW injury incurred during stent retriever thrombectomy can be reliably detected utilizing contrast-enhanced 3-T VW-MRI. The results further demonstrate that endothelial injury is associated with oversizing of stent retrievers relative to the treated vessel. Further studies are needed to evaluate the clinical significance of endothelial injury and to characterize the differential effects of various devices.