bluuebunny/crossref_metadata_2025_split huggingface dataset:
A clinico‐pathologic study of placenta percreta
Authors: Hubinont Corinne , Mhallem Mina , Baldin Pamela , Debieve Frederic , Bernard Pierre , Jauniaux Eric 
Published: November 2017

AbstractObjectiveTo review a single‐center case series of placenta percreta and to evaluate risk factors and the impact of surgical techniques used in previous cesarean delivery.MethodsThe present retrospective cohort study included pregnancies with placenta percreta managed between January 1, 2002, and March 31, 2017, at Saint Luc University Hospital, Brussels, Belgium. The data reviewed included demographics, outcomes, inter‐pregnancy interval, and surgical techniques used for uterine closure in previous cesarean delivery. A cases series of non‐accreta placenta previa was used as a control group.ResultsThere were 19 pregnancies included in the study. The most common ultrasonography signs in the study group were loss of the clear zone (14/17; 82%), placental lacunae (17/17; 100%), and subplacental hypervascularity (11/14; 79%). Median gravidity, parity, and number of previous cesarean deliveries were higher (P<0.05) and inter‐pregnancy interval was longer (P<0.05) in the study group than the control group. There was no difference between the groups in the surgical techniques used for previous cesarean deliveries.ConclusionThe prenatal ultrasonography diagnosis of placenta percreta is accurate and facilitates optimal management by a specialized multidisciplinary team. Multicenter studies are required to further evaluate the impact of the surgical techniques used for prior cesarean delivery on the risks of placenta percreta in subsequent pregnancies.
Modulation of cell responses to Ag‐(MeO2MA‐co‐OEGMA): Effects of nanoparticle surface hydrophobicity and serum proteins on cellular uptake and toxicity
Authors: Anderson Christopher R. , Gnopo Yehou D. M. , Gambinossi Filippo , Mylon Steven E. , Ferri James K. 
Published: November 2017

AbstractNanoparticle (NP) interactions with cellular systems are influenced by both NP physico‐chemical properties and the presence of surface‐bound proteins that are adsorbed in biological environments. Here, we characterize cellular responses to silver nanoparticles (AgNPs) functionalized with poly(di(ethylene glycol) methyl ether methacrylate‐co‐oligo(ethylene glycol) methyl methacrylate) (poly(MeO2MAx‐co‐OEGMAy)) brushes with tunable hydrophobicity and explore how these responses are modulated by the presence or absence of serum proteins. Poly(MeO2MAx‐co‐OEGMAy) with variable composition (5–10% OEGMA) was fabricated to elicit differential hydrophobicity at 37°C for AgNPs capped with these copolymers. The increase in Ag‐(MeO2MAx‐co‐OEGMAy) surface hydrophobicity from (x:y) = 90:10 to (x:y) = 95:5 led to enhanced cytotoxicity of L‐929 fibroblasts and a concomitant increase in cell uptake and reactive oxygen species generation in the presence of serum proteins. These responses were attenuated significantly in serum‐free environments. Broad inhibition of PI3 kinase‐mediated endocytosis reduced both cell uptake and cytotoxicity in the presence or absence of serum proteins. In contrast, selective inhibition of clathrin‐ and caveolae‐mediated endocytosis markedly decreased cell uptake and cytotoxicity in response to Ag‐(MeO2MA95‐co‐OEGMA5) exclusively in the presence of serum proteins, whereas cell responses to the more hydrophilic Ag‐(MeO2MA90‐co‐OEGMA10) were less affected by the inhibition of these pathways with or without serum proteins. This study demonstrates an important role for both NP surface hydrophobicity and the presence of serum proteins in directing cell uptake and subsequent cellular responses, which we suggest has broad application in the design of polymer‐functionalized NPs for specific biological outcomes. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1061–1071, 2018.
Pathological kinematic patterns of the tarsal complex in stage II adult‐acquired flatfoot deformity
Authors: Wang Chen , Wang Heng , Cao Shengxuan , Wang Shaobai , Ma Xin , Wang Xu , Huang Jiazhang , Zhang Chao , Chen Li , Geng Xiang , Wang Kan 
Published: November 2017

ABSTRACTThe in vivo kinematic characteristics of the tarsal joints during gait stance phase were still unclear in adult‐acquired foot deformity (AAFD). This study included seven healthy subjects (14 feet) and 12 stage II AAFD patients (14 feet). The 3D models of tarsal bones were reconstructed based on CT scan. Each subject took standard gait on the single fluoroscopy system. Continuous lateral fluoroscopic images were collected. The key postures during the stance phase were selected. The 2D‐3D registration technique was applied to explore the spatial motions of the tarsal joints in 6 degrees of freedom (DOF). During the whole stance phase, the AAFD talo‐navicular joint (TNJ) exhibited ROM of 13 ± 6° in the sagittal plane while the normal subjects showed ROM of 7 ± 3° (p = 0.004). In AAFD, the subtalar joint (STJ) demonstrated 19 ± 8° and 7 ± 3° of motion in coronal and horizontal plane, respectively, while the normal subjects showed 14 ± 4°(p = 0.031) and 11 ± 3° (p = 0.014) of motion, respectively. Additionally STJ of AAFD patients showed significantly less dorsiflexion during the weight acceptance and showed significantly less external rotation both during the weight acceptance and single limb support of stance phase. In conclusion, for stage II AAFD patients, the talonavicular joint and the subtalar joint showed hypermobility in dorsi/planterflexion and inversion/eversion, respectively, during the gait stance phase while the internal/external rotation of the subtalar joint was reduced. The current study improves our understanding of the pathological kinematics of the tarsal complex in AAFD patients. Notice should be taken about these tarsal joints mobility in AAFD during clinical practice. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:477–482, 2019.
The role of soil chemical properties, land use and plant diversity for microbial phosphorus in forest and grassland soils
Authors: Sorkau Elisabeth , Boch Steffen , Boeddinghaus Runa S. , Bonkowski Michael , Fischer Markus , Kandeler Ellen , Klaus Valentin H. , Kleinebecker Till , Marhan Sven , Müller Jörg , Prati Daniel , Schöning Ingo , Schrumpf Marion , Weinert Jan , Oelmann Yvonne 
Published: November 2017

AbstractManagement intensity modifies soil properties, e.g., organic carbon (Corg) concentrations and soil pH with potential feedbacks on plant diversity. These changes might influence microbial P concentrations (Pmic) in soil representing an important component of the P cycle. Our objectives were to elucidate whether abiotic and biotic variables controlling Pmic concentrations in soil are the same for forests and grasslands, and to assess the effect of region and management on Pmic concentrations in forest and grassland soils as mediated by the controlling variables. In three regions of Germany, Schwäbische Alb, Hanich‐Dün, and Schorfheide‐Chorin, we studied forest and grassland plots (each n = 150) differing in plant diversity and land‐use intensity. In contrast to controls of microbial biomass carbon (Cmic), Pmic was strongly influenced by soil pH, which in turn affected phosphorus (P) availability and thus microbial P uptake in forest and grassland soils. Furthermore, Pmic concentrations in forest and grassland soils increased with increasing plant diversity. Using structural equation models, we could show that soil Corg is the profound driver of plant diversity effects on Pmic in grasslands. For both forest and grassland, we found regional differences in Pmic attributable to differing environmental conditions (pH, soil moisture). Forest management and tree species showed no effect on Pmic due to a lack of effects on controlling variables (e.g., Corg). We also did not find management effects in grassland soils which might be caused by either compensation of differently directed effects across sites or by legacy effects of former fertilization constraining the relevance of actual practices. We conclude that variables controlling Pmic or Cmic in soil differ in part and that regional differences in controlling variables are more important for Pmic in soil than those induced by management.
Rapid authentication of edible bird's nest by FTIR spectroscopy combined with chemometrics
Authors: Guo Lili , Wu Yajun , Liu Mingchang , Ge Yiqiang , Chen Ying 
Published: November 2017

AbstractBACKGROUNDEdible bird's nests (EBNs) have been traditionally regarded as a kind of medicinal and healthy food in China. For economic reasons, they are frequently subjected to adulteration with some cheaper substitutes, such as Tremella fungus, agar, fried pigskin, and egg white. As a kind of precious and functional product, it is necessary to establish a robust method for the rapid authentication of EBNs with small amounts of samples by simple processes. In this study, the Fourier transform infrared spectroscopy (FTIR) system was utilized and its feasibility for identification of EBNs was verified.RESULTSFTIR spectra data of authentic and adulterated EBNs were analyzed by chemometrics analyses including principal component analysis, linear discriminant analysis (LDA), support vector machine (SVM) and one‐class partial least squares (OCPLS). The results showed that the established LDA and SVM models performed well and had satisfactory classification ability, with the former 94.12% and the latter 100%. The OCPLS model was developed with prediction sensitivity of 0.937 and specificity of 0.886. Further detection of commercial EBN samples confirmed these results.CONCLUSIONFTIR is applicable in the scene of rapid authentication of EBNs, especially for quality supervision departments, entry–exit inspection and quarantine, and customs administration. © 2017 Society of Chemical Industry
Numerical and Experimental Evaluation of High‐Intensity Focused Ultrasound–Induced Lesions in Liver Tissue Ex Vivo
Authors: Haddadi Samaneh , Ahmadian Mohammad Taghi 
Published: November 2017

ObjectivesRecent advances in the field of acoustics and piezoelectric and ultrasound transducers have led to new approaches to the diagnosis and treatment of certain diseases. One method of treatment with ultrasonic waves is high‐intensity focused ultrasound (HIFU) treatment, which is a thermal therapeutic method used to treat malignant tumors. Although a variety of treatment‐planning strategies using ultrasonic waves have been investigated, little clinical success has been achieved. Computational modeling is a powerful tool for predicting device performance.MethodsThe heating induced by a concave transducer with operating powers of 85 and 135 W was studied, and the experimental results presented in this article verify its applicability. Numerical simulations of the nonlinear acoustic field were performed by using the Westervelt and Khokhlov‐Zabolotskaya‐Kuznetsov equations. Heat transfer was measured for the 2 operational powers, and the results were compared with ex vivo experimental results. In addition, thermal dose contours for both the simulation and experimental results were calculated to investigate the ablated area.ResultsGood agreement was found between the experimental and numerical results. The results show that the average temperature deviations calculated at the focal point were 12.8% and 4.3% for transducer powers of 85 and 135 W, respectively.ConclusionsThis study provides guidance to HIFU practitioners in determining lesion size and identifying nonlinear effects that should be considered in HIFU procedures.
Extracranial and Intracranial Ultrasonographic Findings in Posterior Circulation Infarction
Authors: Chi Hsin‐Yi , Hsu Chung‐Fu , Chen An‐Chih , Su Chun‐Hung , Hu Han‐Hwa , Fu Wen‐Mei 
Published: November 2017

ObjectivesPatients with posterior circulation infarction are at higher risk of early recurrent stroke, especially those with vertebrobasilar stenosis or hypoplasia. The clinical presentations of this condition vary over a broad range, making diagnosis and treatment a challenge. Hemodynamic changes and stenosis detected by ultrasonography (US) are sensitive and important indicators for further evaluation. In this study, we correlated extracranial and intracranial US characteristics with brain magnetic resonance imaging (MRI) in patients with posterior circulation infarction.MethodsInpatients with acute ischemic stroke who received both MRI and US were enrolled. Baseline characters, underlying disorders, the ischemic territory, and vascular stenosis on MRI were recorded. Series of US data, including flow volume, diameter, mean velocity, and pulsatility index, were analyzed. Patients with new infarction over the medulla, pons, midbrain, or cerebellum were enrolled as the posterior circulation infarction group. Patients with pure anterior circulation infarction were also enrolled.ResultsA total of 210 patients with anterior circulation infarction (mean age ± SD, 66.24 ± 12.88 years) and 143 with posterior circulation infarction (mean age, 65.82 ± 11.39 years) were enrolled. Significant higher frequencies of vertebral artery hypoplasia and decreased intracranial vertebrobasilar velocity in the posterior circulation infarction group (44.75% and 64.33%, respectively) were documented (P < .0001; P = .035). Ischemic lesion distributions were correlated with vertebral artery hypoplasia (55.56 %) and low vertebral and basilar artery velocities (44.44% and 25.53%), as documented by US. A low vertebrobasilar velocity was highly correlated with MRI‐documented vascular stenosis (53.06%).ConclusionsVertebral artery hypoplasia and a low velocity in the intracranial vertebrobasilar system on US might change the treatment of patients with posterior circulation infarction for primary and secondary prevention.
Two kinds of fixed point theorems and reverse mathematics
Authors: Peng Weiguang , Yamazaki Takeshi 
Published: November 2017

AbstractIn this paper, we investigate the logical strength of two types of fixed point theorems in the context of reverse mathematics. One is concerned with extensions of the Banach contraction principle. Among theorems in this type, we mainly show that the Caristi fixed point theorem is equivalent to over . The other is dedicated to topological fixed point theorems such as the Brouwer fixed point theorem. We introduce some variants of the Fan‐Browder fixed point theorem and the Kakutani fixed point theorem, which we call and , respectively. Then we show that is equivalent to and is equivalent to , over . In addition, we also study the application of the Fan‐Browder fixed point theorem to game systems.
The Proteomic Response of Bacillus pumilus Cells to Glucose Starvation
Authors: Handtke Stefan , Albrecht Dirk , Otto Andreas , Becher Dörte , Hecker Michael , Voigt Birgit 
Published: November 2017

AbstractSince starvation for carbon sources is a common condition for bacteria in nature and it can also occur in industrial fermentation processes due to mixing zones, knowledge about the response of cells to carbon starvation is beneficial. The preferred carbon source for bacilli is glucose. The response of Bacillus pumilus cells to glucose starvation using metabolic labeling and quantitative proteomics was analyzed. Glucose starvation led to an extensive reprogramming of the protein expression pattern in B. pumilus. The amounts of proteins of the central carbon metabolic pathways (glycolysis and TCC) remained stable in starving cells. Proteins for gluconeogenesis were found in higher amounts during starvation. Furthermore, many proteins involved in acquisition and usage of alternative carbon sources were present in elevated amounts in starving cells. Enzymes for fatty acid degradation and proteases and peptidases were also found in higher abundance when cells entered stationary phase. Among the proteins found in lower amounts were many enzymes involved in amino acid and nucleotide synthesis and several NRPS and PKS proteins.
Practical Remediation of 3‐Nitro‐1,2,4‐triazol‐5‐one Wastewater
Authors: Chew Siao Chien , Tennant Mat , Mai Nathalie , McAteer Daniel , Pons Jean‐François 
Published: November 2017

AbstractLimiting environmental impact is a top priority for the chemical industry, and manufacturing practices need to be well controlled to avoid any potential contamination. In order to reduce waste streams during the processing of 3‐nitro‐1,2,4‐triazol‐5‐one (NTO), potentially evironmental hazardous at concentrations of 1 g/l, we investigated the potential remediation and recycling of water using a wide range of commercial sorption media. We studied the effect of experimental conditions, including flow rate, initial contaminant concentration and temperature. This led to the selection of Amberlyst A26 OH in a batch process and Activated Carbon in continuous flow, as the most effective sorption methods. Using high performance liquid chromatography photodiode array detection (HPLC‐PDA), NTO was quantified from solutions, before and after remediation, showing a complete removal from a 10 g/l NTO solution. Our purification method therefore appears to be suitable for the remediation of NTO‐contaminated wastewater.
Thermodynamic secrets of multidrug resistance: A new take on transport mechanisms of secondary active antiporters
Authors: Zhang Xuejun C. , Liu Min , Lu Guangyuan , Heng Jie 
Published: November 2017

AbstractMultidrug resistance (MDR) presents a growing challenge to global public health. Drug extrusion transporters play a critical part in MDR; thus, their mechanisms of substrate recognition are being studied in great detail. In this work, we review common structural features of key transporters involved in MDR. Based on our membrane potential‐driving hypothesis, we propose a general energy‐coupling mechanism for secondary‐active antiporters. This putative mechanism provides a common framework for understanding poly‐specificity of most—if not all—MDR transporters.
Nash equilibria for nonzero-sum ergodic stochastic differential games
Authors: Cohen Samuel N. , Fedyashov Victor 
Published: November 2017

Abstract
We consider nonzero-sum games where multiple players control the drift of a process, and their payoffs depend on its ergodic behaviour. We establish their connection with systems of ergodic backward stochastic differential equations, and prove the existence of a Nash equilibrium under generalised Isaac's conditions. We also study the case of interacting players of different type.
Connections of Gini, Fisher, and Shannon by Bayes risk under proportional hazards
Authors: Asadi Majid , Ebrahimi Nader , Soofi Ehsan S. 
Published: November 2017

Abstract
The proportional hazards (PH) model and its associated distributions provide suitable media for exploring connections between the Gini coefficient, Fisher information, and Shannon entropy. The connecting threads are Bayes risks of the mean excess of a random variable with the PH distribution and Bayes risks of the Fisher information of the equilibrium distribution of the PH model. Under various priors, these Bayes risks are generalized entropy functionals of the survival functions of the baseline and PH models and the expected asymptotic age of the renewal process with the PH renewal time distribution. Bounds for a Bayes risk of the mean excess and the Gini's coefficient are given. The Shannon entropy integral of the equilibrium distribution of the PH model is represented in derivative forms. Several examples illustrate implementation of the results and provide insights for potential applications.
The failure probability of components in three-state networks with applications to age replacement policy
Authors: Ashrafi S. , Asadi M. 
Published: November 2017

Abstract
In this paper we investigate the stochastic properties of the number of failed components of a three-state network. We consider a network made up of n components which is designed for a specific purpose according to the performance of its components. The network starts operating at time t = 0 and it is assumed that, at any time t > 0, it can be in one of states up, partial performance, or down. We further suppose that the state of the network is inspected at two time instants t1 and t2 (t1 < t2). Using the notion of the two-dimensional signature, the probability of the number of failed components of the network is calculated, at t1 and t2, under several scenarios about the states of the network. Stochastic and ageing properties of the proposed failure probabilities are studied under different conditions. We present some optimal age replacement policies to show applications of the proposed criteria. Several illustrative examples are also provided.
Central limit theorem for the Horton–Strahler bifurcation ratio of general branch order
Authors: Yamamoto Ken 
Published: November 2017

Abstract
The Horton–Strahler ordering method, originating in hydrology, formulates the hierarchical structure of branching patterns using a quantity called the bifurcation ratio. The main result of this paper is the central limit theorem for the bifurcation ratio of a general branch order. This is a generalized form of the central limit theorem for the lowest bifurcation ratio, which was previously proved. Some useful relations regarding the Horton–Strahler analysis are also derived in the proofs of the main theorems.
Optimal scaling of the random walk Metropolis algorithm under Lp mean differentiability
Authors: Durmus Alain , Le Corff Sylvain , Moulines Eric , Roberts Gareth O. 
Published: November 2017

Abstract
In this paper we consider the optimal scaling of high-dimensional random walk Metropolis algorithms for densities differentiable in the Lp mean but which may be irregular at some points (such as the Laplace density, for example) and/or supported on an interval. Our main result is the weak convergence of the Markov chain (appropriately rescaled in time and space) to a Langevin diffusion process as the dimension d goes to ∞. As the log-density might be nondifferentiable, the limiting diffusion could be singular. The scaling limit is established under assumptions which are much weaker than the one used in the original derivation of Roberts et al. (1997). This result has important practical implications for the use of random walk Metropolis algorithms in Bayesian frameworks based on sparsity inducing priors.
Human CD26high T cells elicit tumor immunity against multiple malignancies via enhanced migration and persistence
Authors: Bailey Stefanie R. , Nelson Michelle H. , Majchrzak Kinga , Bowers Jacob S. , Wyatt Megan M. , Smith Aubrey S. , Neal Lillian R. , Shirai Keisuke , Carpenito Carmine , June Carl H. , Zilliox Michael J. , Paulos Chrystal M. 
Published: November 2017

AbstractCD8+T lymphocytes mediate potent immune responses against tumor, but the role of human CD4+T cell subsets in cancer immunotherapy remains ill-defined. Herein, we exhibit that CD26 identifies three T helper subsets with distinct immunological properties in both healthy individuals and cancer patients. Although CD26negT cells possess a regulatory phenotype, CD26intT cells are mainly naive and CD26highT cells appear terminally differentiated and exhausted. Paradoxically, CD26highT cells persist in and regress multiple solid tumors following adoptive cell transfer. Further analysis revealed that CD26highcells have a rich chemokine receptor profile (including CCR2 and CCR5), profound cytotoxicity (Granzyme B and CD107A), resistance to apoptosis (c-KIT and Bcl2), and enhanced stemness (β-catenin and Lef1). These properties license CD26highT cells with a natural capacity to traffic to, regress and survive in solid tumors. Collectively, these findings identify CD4+T cell subsets with properties critical for improving cancer immunotherapy.