bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of the Italian Version of the “abnormal Bodily Phenomena Questionnaire” in a Sample of Patients with Schizophrenia: Preliminary Data
Authors: Chieffi M. , Palumbo D. , Patriarca S. , Plescia G. , Montefusco V. , Pietrafesa D. , Mucci A. , Galderisi S. 
Published: June 2017

IntroductionThe abnormal bodily phenomena questionnaire (ABPq) originates from the analysis of clinical files of more than 350 patients with schizophrenia. It consists in a semi-structured interview created to evaluate the subjective anomalies in feelings, sensations, perceptions and cognition in the domain of the lived body.ObjectivesThe present study is aimed at providing preliminary data for the validation of the Italian version of the ABPq.MethodsThe ABPq was translated and adapted into Italian. ABPq scores were correlated to those obtained by the schizophrenia proneness instrument, Adult version–body perception disturbances (SPI-A E, body) that evaluates the same kind of phenomena, in order to examine its convergent validity. Moreover, ABPq was correlated to psychopathological domains assessed by the Positive and Negative Syndrome Scale (PANSS) and by the Brief Negative Symptom Scale (BNSS).ResultsThe experimental sample included 40 clinically stable patients. Our findings showed a strong correlation between ABPq and SPI-A E, body. An association of ABPq total score with the positive and disorganized dimensions was also observed.ConclusionsOur preliminary data suggest that the Italian version of ABPq has a good convergent validity. The presence of abnormal bodily phenomena resulted to be associated to a greater severity of the disease and therefore it could be hypothesized that they represent an indicator of clinical severity.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Confirmatory Factor Analyses of the Portuguese Version of the Maudsley Obsessional-compulsive Inventory
Authors: Ribeiro J. Silva , Pereira A.T. , Martins M.J. , Nogueira V. , Soares M.J. , Amaral A.P. , Macedo A. 
Published: June 2017

IntroductionThe Maudsley obsessional-compulsive inventory (MOCI) is a widely used self-report measure of obsessive-compulsive symptoms in clinical and non-clinical populations, both in research and clinical settings. Nogueira et al. confirmed in 2011 that the MOCI Portuguese version has good psychometric properties, having a factorial structure that is in accordance with those reported by other groups.AimsBased on the previous results of exploratory factor analysis with a Portuguese students sample, the present study aimed to perform a confirmatory factor analyses (using Mplus software) to verify if the three dimensions’ structure fitted the data.MethodsThe sample comprised 234 students on their first three years of college education (78.2% female), between 18–26 years old (M = 20.55; SD = 1.66). Participants filled the Portuguese version of the MOCI.ResultsOur results showed that the MOCI Portuguese version with original 3-factor structure has a good fit (χ2(227) = 386.987, P < .05; RMSEA = 0.053, 90%CI = 0.044–0.062; CFI = 0.928; TLI = 0.920; WRMR = 1.089). Good reliability was found for all subscales (Cronbach alpha < .80).ConclusionsThe MOCI Portuguese version reliably and validly assesses three OC symptom dimensions in young adults. Further research is needed to confirm this structure in Portuguese clinical samples.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Interplay of Gut Microbiota, Body Mass Index and Depression Scores in Anorexia Nervosa: Preliminary Data
Authors: Mörkl S. , Lackner S. , Gorkiewicz G. , Kashofer K. , Blesl C. , Tmava A. , Oberascher A. , Holasek S. 
Published: June 2017

IntroductionAnorexia nervosa (AN) is a lethal psychiatric disease with only narrow treatment possibilities. Recent study results point out, that gut microbiota might be a contributing factor in the development and persistence of AN through effects on the gut-brain-axis.MethodsWe used 16SRNA sequencing to characterize the composition and diversity of the gut microbiota of 18 AN patients, 19 normal weight controls and 19 athletes matched by age using stool samples. The QIIME-pipeline was used to assess the sequencing result. All participants completed an activity-questionnaire (IPAQ) and inventories to measure depression (BDI, HAMD).ResultsKruskal-Wallis test identified significant differences in alpha-diversity (Chao-1-estimator [P = 0.013], number of observed species [P = 0.027]) between groups. Spearman-Correlation revealed a significant correlation of number of observed species (r = 0.366, P = 0.006) Chao-1-estimator (r = 0.352, P = 0.008) and BMI (Fig. 1). Furthermore, a higher BMI was related to lower depression scores (r = 0.351, P < 0.001). Although there was a tendency of a negative correlation of BDI-scores and alpha-diversity (r = –0.180, P = 0.059), correlations with depression scores and IPAQ-scores did not reach significance level (Fig. 1).ConclusionsOur preliminary data demonstrate correlations of alpha-diversity and BMI. Further studies are needed to provide further insights in AN gut microbiota and its influence factors.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Identification of Novel Genes Associated to Major Mental Disease by Whole Exome Sequencing in Families with High Prevalence
Authors: Pol Fuster J. , Ruiz Guerra L. , Ortega Vila B. , Medina Dols A. , Bisbal Carrió B. , Lladó J. , Olmos G. , Heine Suñer D. , Cañellas F. , Vives Bauzà C. 
Published: June 2017

IntroductionThe identification of new genetic variants underlying psychosis is crucial to improve its molecular diagnosis and to determine the disease etiology, which is necessary to develop new therapeutic targets.AimTo identify novel rare genetic variants associated to mental disorders, using whole exome sequencing (WES).MethodsTwo families with high prevalence of mental disease were genotyped using WES. The first family has 5 members affected, the mother with a bipolar disorder, three sons, two with schizophrenia and one with schizoaffective disorder, and a cousin with major depression and psychotic symptoms. The second family is constituted by 38 members affected by major mental diseases in three generations. Key affected members of each family were genotyped by WES. Shared rare variants, with allelic frequencies below 0.5% in general population, were identified among the affected members of the family. The segregation of those variants was confirmed by Sanger sequencing.ResultsIn family 1, thirty-seven genetic variants related to neurodevelopment were identified. Two of those variants in the genes TRIP12 and RNF25 segregated with psychosis. In family 2, seven rare genetic variants contained in genes related to neurodevelopment were identified. A mutation in the gene ARHGAP19 segregated with psychosis.ConclusionsThree new genes have been found to be associated with psychosis. TRIP12 and RNF25 encode two E3-ubiquitin ligases which modulate the Wnt pathway, mutations in which lead to neurodevelopmental defects. ARHGAP19 encodes a GTPase which regulates the RhoA protein, involved in the regulation of the cytoskeleton.Disclosure of interestThe authors have not supplied their declaration of competing interest.
The Effects of Deep-brain Magnetic Stimulation (DMS) on White Matter Deficits: New Mechanism in Major Depressive Disorder (MDD) Treatment
Authors: Zhang Y. , Zhang D. , Feng S. , Guo H. , Zhang H. , Bowen R. , Li X.M. 
Published: June 2017

Deep-brain magnetic stimulation (DMS) is an effective therapy for various neuropsychiatric disorders including major depression disorder. The molecular and cellular mechanisms underlying the impacts of DMS on the brain remain unclear. Studies have reported abnormalities in the white matter of depressive brains, suggesting the involvement of myelin and oligodendrocyte pathologies in the development of major depressive disorder. In this study, we use a cuprizone induced demyelination animal model to generate depressive like behaviours and white matter and oligodendrocyte damages. Meanwhile, we treated the animal with DMS 20 minutes daily during the cuprizone challenge or recovery period. Behavioural tests, including nesting, new objective recognition, working memory and depression-like behaviours were tested periodically. Histological staining and western blotting were used to examine the underlying mechanism of DMS. We found that DMS reverse cuprizone induced behavioural deficits in acute demyelination but not during the recovery period. DMS alleviated demyelination and inflammation induced by cuprizone. During the recovery period, DMS had no impacts on overall neural progenitor cell proliferation, but enhanced the maturation of oligodendrocyte. This data suggest that DMS may be a promising treatment option for improving white matter function in psychiatric disorders and neurological diseases in future.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Regression models for biopsychosocial factors affecting patients with haemoglobinopathies in a Greek hospital
Authors: Lyrakos G. , Aslani E. , Spinaris V. , Drossou-Servou M. , Tsironi M. 
Published: June 2017

IntroductionSickle cell and thalassemia (haemoglobinopathies) are autosomal recessive inherited conditions that affect haemoglobin and as chronic diseases, stress, anxiety and depression are comorbid conditions.ObjectivesTo examine possible biopsychosocial factors affecting stress, anxiety and depression symptoms in these patients.AimsTo investigate whether different condition related markers, contribute to the psychological symptomatology.MethodsA total of 97 patients participated in the study, 21 males (21.6%) and 76 females (78.4%), with a mean age of 44.35. Convenience sampling method was used and participants were recruited from the General Hospital of Nikaia, ‘Ag. Panteleimon’, in Athens, Greece. DASS and MFI scales were used to measure the dependent and independent variables. Data were analysed with the SPSS 21 software.ResultsMultivariate analysis revealed that days between transfusions (beta = −0.454), reduced activity (beta = 0.350) and age (beta = −0.207) explained 30.1% of the variance in Stress [F(3.91) = 13.04 R2 = 0.301 P = 0.03]. Reduced activity (beta = 0.417) and days between transfusions (beta = 0.318) explained 30,3% of the variance in Anxiety [F(2.92) = 19.96 R2 = 0.301 P = 0.03]. Finally reduced activity (beta = 0.334), days between transfusions (beta = 0.364), and reduced motivation explained 41.3% of the variance in Depression [F(3.91) = 21.34 R2 = 0.413 P = 0.03]. Levels of ferritin, haemoglobin, age and present condition of health had a NS effect in the models.ConclusionsSimilar factors were found to affect stress, anxiety and depression in the sample, with days between transfusions and reduced activity being the major factors affecting the psychological symptoms in haemoglobinopathy patients. More research is needed in order for all the biopsychosocial factors to be revealed in this field.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Diagnosis of generalized anxiety disorder in Russia: The results of a web-based survey of psychiatrists
Authors: Martynikhin I. , Neznanov N. , Mosolov S. 
Published: June 2017

IntroductionThere is a lack of attention on generalized anxiety disorder (GAD) in the psychiatrists’ education programs in Russia. The consequence of this is difficult to estimate because of insufficiency of the GAD epidemiology in Russia.ObjectivesAre estimation of the comparative prevalence of diagnosis of GAD among other anxiety and stress related disorders; psychiatrists’ knowledge about GAD and theirs therapeutic approaches.MethodsThe invitations to survey were sent by e-mail to members of the Russian Society of Psychiatrists; 888 psychiatrists took part in the survey. Twenty-six percent of them worked in inpatient departments, 43% – in outpatient departments, 15% – in somatic services, 17% – researchers and university professors.ResultsA total of 83% of respondents have diagnosed GAD at least once during last year. Most often GAD was diagnosed by psychiatrists of somatic services. Mixed anxiety and depressive disorder was diagnosed in 2.5 times more often than GAD; adjustment disorders – in 2.1 times. Doctors have noted that among their patients with other mental disorders 26% have chronic anxiety, but most of doctors do not establish the comorbid diagnosis of GAD for these patients. Only a quarter of doctors consider that detachment of GAD from other anxiety disorders is based on the features of etiology and pathogenesis. In the treatment of GAD together with SSRIs, SNRIs, and pregabalin prescribing, doctors often prescribe benzodiazepines, atypical anxiolytics (hydroxyzine, buspirone) and low-potency antipsychotics (alimemazine, chlorprothixene).ConclusionsIncreasing attention to GAD in the psychiatrists’ education programs may improve diagnosis and treatment of this disorder in Russia.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Pregnancy in men: Couvade syndrome
Authors: Navas M. , García Albea J. , García-Parajuá P. 
Published: June 2017

As human reproduction has to been seen not only from the biological (gender) but from the social and anthropological perspective, and as long as paternity joins a very important aspect in men identity, we found essential to review actual and past literature in order to explain symptoms and attitudes experienced by some fathers to be.Couvade syndrome was first described in the mid-sixties by a group of British authors who tried to analyze some typical pregnancy symptoms observed in fathers to be. These symptoms are heterogeneous and could be difficultly classified, but must of the authors tend to group them in anxiety or somatophorm-like disorders.In this oral communication, we will explore into the deep causes of this syndrome and its links to the Couvade ritual described in some ancient cultures like the Greek (year 60 B.C.) as well as analyze an actual case report, with the help of the exhaustive revision of the existing literature.Couvade has to be contemplated as a way to define the new identity of the father to be, and his bond with the newborn, his couple and the society.Finally, Couvade could be seen as a proactive and constructive preparation of the male to the paternity, out of psycopathology and recognize these comprehensive reactions as a normal and functional part of the reproductive ritual.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Cognitive impairment and its relation to predominant polarity, number of episodes and illness duration in patients with euthymic bipolar affective disorder (BAD)
Authors: Ratnatunga S.S. , Kulathilake I.C. , Kokila Medhavini K. , Dayabandara M. , Rajapakse I. , Hanwella R. , de Silva V. 
Published: June 2017

IntroductionPrevious optimistic assumptions about the prognosis of BAD based on the control of mood symptoms is now challenged as majority of patients continue to have cognitive deficits during the euthymic phase.ObjectivesTo describe cognitive impairment in euthymic BAD and study the association with clinical characteristics.AimsIdentify the prevalence and severity of cognitive impairment (CI); to correlate CI with the first episode, illness duration, number of episodes and predominant polarity.MethodsPatients attending the psychiatry clinic of the National Hospital of Sri Lanka diagnosed with BAD in the remission phase were recruited. An interviewer-administered questionnaire and Montreal Cognitive Assessment test was used to ascertain clinical characteristics and cognitive functions respectively. Scores of 18–26 described as mild, 10–17 moderate and < 10 as severe cognitive impairment.ResultsTotal sample size was 58. Mean age = 48.84 (SD12.5). Fifty-five percent were females. Mean duration of illness was 179.7 months (SD128.5). A mean of 6 episodes were experienced during the course of illness (min = 1, max = 18); 58.6% had depression, 37.9% had manic and 3.4% had mixed as their first episode. The predominant polarity was depressive in 65.5%. No cognitive impairment – 8.6%, mild – 63.8%, moderate – 27.6% and none with severe. There was a significant association between the presence of cognitive impairment and the predominant polarity being depressive (r = 10.886, df = 4, P = 0.028). No significant association was found between illness duration, number of episodes or the type of first episode.ConclusionsPatients with a predominant depressive polarity are more likely to experience cognitive impairment. Cognitive impairment had no association with illness duration, type of episode or number of episodes.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Aviation mental disorders – An in-flight case of mania
Authors: Ribeirinho Marques A. , Veludo Chai M. , Cintra P. , Gonçalves V. , Esteves de Sousa D. , Albuquerque M. , Nuno Costa M. 
Published: June 2017

IntroductionDue to recent aviation accidents, like German Wings flight 9525, aviation related mental health disorders have recently received much attention. Several psychological disorders have been associated with aviation ever since its beginning, both in passengers and aviation professionals. A clinical case is revised of a 33 years old air hostess, without previous psychiatric history, who was admitted twice in a manic state, and a third time abroad in Nice, France, after prolonged sleep privation due to consecutive transatlantic flights.ObjectivesScientific revision of psychological disorders in passengers (flight related psychological stress, flight phobia, post-traumatic stress disorders after plane crashes…), aviation professionals (mood changes, sexual function disorders, jet lag, sleep disorders), ground staff, and populations living within close distance to airports (burnout, circadian rhythms disorders due to high noise levels…).MethodsResearch in Pubmed, Medscape, scientific literature and other publications, with the following research terms: aviation related mental health disorders, flight related psychological disorders, flight phobia, aerophobia, aviophobia, flight related anxiety, flight related mood disorders, flight induced mania, psychological stress and air travel; articles in English, Portuguese and Spanish.ResultsFifty-eight articles, one book and four publications were considered relevant; the case of the patient is thoroughly described with data retrieved from the clinical file.ConclusionsSeveral important issues concerning both mental and physical health are highlighted by this clinical case, yet, surprisingly, scientific knowledge has progressed at a rather slow pace and mental health professionals have not given much attention to this issue.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Mind your anger habits: For teen (group CBT for teens with anger behavioral problems)
Authors: Eraky S. 
Published: June 2017

Problematic anger behaviors of children and adolescents represent a significant challenge to the clinical community. Although a number of direct and indirect factors are theorized to contribute to the etiology of aggressive behavioral problems, the cognitive-behavioral model focuses on the cognitive processes that play a significant role in the generation of anger and the aggressive responses to provocation. “Mind your anger habits: for teen” manual, is based on the cognitive-behavioral conceptualization of anger and anger management problems functions, it consists of 10 group sessions for teens and 8 group sessions for their parents.In the “Mind your anger habits: for teen”; anger is identified as a stress reaction with three response components: cognitive, physiological, and behavioral. The cognitive component is characterized by one's perception of social stimuli and provocation cues in the social context, by one's interpretation of these stimuli, by one's attributions concerning causality and/or responsibility, and by one's evaluation of oneself and the situation. This component represents a significant area for intervention with aggressive adolescents as their perceptions and attitudes serve to prompt most behavioral responses to provocation. Research on the social and cognitive processing in aggressive youth indicates that distorted interpretations, attributional biases, and deficiencies in problem solving can all influence the selection of aggressive behavior responses. Furthermore, cognitive processing patterns are likely to become more rigid over time, and as such the maladaptive aggressive behaviors prompted by dysfunctional cognitions will be maintained.Disclosure of interestThe author has not supplied his declaration of competing interest.
Guide for adults in the children's therapeutic tale: “I conquered my fears”
Authors: Lima C. , Cunha G. , Figueiredo M. , Moreira F. 
Published: June 2017

The book “I conquered my fears” was created as a result of the clinical experience of the author. It is a therapeutic tale, which is valid as a resource to be used by health workers and parents so as to help children overcome their fears at bedtime.Because experience is important for an adult so as to better reflect on the theme, the book also includes an appendix to help accordingly.The adult is invited to express what he/she likes to hear the most and the least, when waking from a sleepless night, and is also invited to dynamically interact with the book, give answers and create hypothesis, with no fear of making mistakes.The parents, after reading the book, refer a better stress management capacity at critical moments experienced with the children at bedtime.Disclosure of interestThe authors have not supplied their declaration of competing interest.
A descriptive study of a sample of 42 male diagnosed psychotic disorder
Authors: Martí Garnica V. , Ortega Garcia M.D. , López Bernal M.A. , Russo De Leom J.R. , Marin Garcia S. 
Published: June 2017

The aim of this study is the approach to mental illness and specifically in serious mood disorders, long-term treatments that improve adhesion as continuous treatments ensure compliance are needed, they minimize the risk of relapse and readmission and therefore increase the chances to have a good fit and social, relational and even occupational functioning. We analyzed a sample of 42 male diagnosed with schizophrenia, schizoaffective disorder, chronic delusional disorder that starts treatment with paliperidone palmitate in outpatients. It is analyzed the dose of paliperidone palmitate employed for stabilization and family satisfaction at the time of stabilization is analyzed in the study. Our results are that the mean dose of paliperidone palmitate is 138 mg. The patient diagnosed with schizophrenia are 47.6% and the average dose is 132.5 mg. Chronic delusional disorder is 2.3% and the mean dose 50 mg. Other comorbidity mood disorders are 21.4% and the mean dose is183 mg. Other disorders (F70, F72…) are 28.5% and mean dose 133 mg. The average family satisfaction (minimum 1 up to 5) is 4, with the highest score among patients diagnosed with F20. Schizophrenia. To conclude, long lasting injectable achieves important adherence and high percentage of antipsychotic monotherapy, thus reducing the side effects although our sample 4.7% which has occurred removed therefore.Disclosure of interestThe authors have not supplied their declaration of competing interest.