bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volatile composition and sensory profile of Cantharellus cibarius Fr. as affected by drying method
Authors: Politowicz Joanna , Lech Krzysztof , Sánchez‐Rodríguez Lucía , Szumny Antoni , Carbonell‐Barrachina Ángel A 
Published: May 2017

AbstractBACKGROUNDIn this work, the influence of different drying methods on the aroma composition and sensory quality of chanterelle mushrooms (Cantharellus cibarius Fr.) was evaluated. The drying methods tested were convective drying (CD), freeze drying (FD), vacuum microwave drying (VMD) and a combination of convective pre‐drying and vacuum microwave finish drying (CPD‐VMFD).RESULTSAnalyses of fresh and dried chanterelle samples by HS‐SPME and GC/MS and GC‐FID showed the presence of 39 volatile compounds at different concentrations. The most abundant compounds in fresh chanterelle were 1‐hexanol (33.4 μg per 100 g dry basis (db)), 1‐octen‐3‐ol (80.2 μg per 100 g db) and 2‐octen‐1‐ol (19.3 μg per 100 g db). The results showed that fresh and dried chanterelle contained very low levels of aroma compounds; however, the highest contents of volatile compounds were found in samples after (i) CD at 80 °C (129 μg per 100 g db), (ii) CPD‐VMFD at 70 °C‐480/240 W (136 μg per 100 g db) and (iii) CPD‐VMFD at 80 °C‐480/240 W (136 μg per 100 g db).CONCLUSIONThe best dehydration methods, which resulted in high contents of volatile compounds and appropriate sensory quality, according to descriptive sensory analysis and PCA tools, were CD at 70 and 80 °C. Besides, these methods led to spongy dried mushrooms with high intensities of fresh, mushroom ID, with proper color and without intense shrinkage. © 2017 Society of Chemical Industry
Evaluation of a mixed anionic–nonionic surfactant modified eggshell membrane as an advantageous adsorbent for the solid‐phase extraction of Sudan I–IV as model analytes
Authors: Li Ying , Wang Anyi , Bai Yunfei , Wang Shiping 
Published: May 2017

The coadsorption of mixed anionic–nonionic surfactants, sodium dodecylbenzenesulfonate with Triton X‐100, on the surface of eggshell membrane was investigated based on adsorption isotherms to improve the solid‐phase extraction performance of eggshell membrane toward organic contaminants. Results showed that even though excess Triton X‐100 might inhibit the adsorption of sodium dodecylbenzenesulfonate, a low dosage of Triton X‐100 can significantly improve sodium dodecylbenzenesulfonate modification and enhance the extraction efficiency of eggshell membrane from 73.7 to 100.4% because of the formation of mixed hemimicelles. The highest recovery was achieved at 2:8 (Triton X‐100/sodium dodecylbenzenesulfonate mass ratios), and multiple mechanisms involving π–π interactions, hydrophobic effect, and π–π electron donor–acceptor interactions contributed to the strong extraction affinity. When mixed, the Triton X‐100 and sodium dodecylbenzenesulfonate modified eggshell membrane packed cartridge coupled with high‐performance liquid chromatography was applied for the simultaneous determination of trace Sudan I–IV, and low detection limits (0.16–0.26 ng/L) were achieved with satisfactory linearity (R2 > 0.999) in 10–10 000 μg/L. For real samples, Sudan II and III in one chilli sauce sample were found at 4.3 and 1.7 μg/kg. Sudan I–IV recoveries at three spiked levels were 87.4–102.9% with precisions <6.8%. Comparison with commonly used solid‐phase extraction adsorbents and methods further reflected the superiorities of the proposed adsorbent in sensitivity, retention ability, and applicability.
Geomechanical modeling of hydrate‐bearing sediments during dissociation under shear
Authors: Lin Jeen‐Shang , Seol Yongkoo , Choi Jeong Hoon 
Published: May 2017

SummaryMethane hydrate‐bearing sediments exist throughout the world in continental margins and in Arctic permafrost. Hydrates are ice‐like compounds when dissociate due to temperature rise or reduction in fluid pressure, release gas. Because of the mechanical property changes caused by dissociation in which the loads supported by the hydrates are transferred to soil grains, these sediments may become unstable. To quantify the risk of ground instability triggered by dissociation, which may happen during operation to extract methane gas or from climate changes, a reliable predictive model is indispensable. Even though many models have been proposed, a detailed validation of the ability to model dissociation impact is still needed. This study investigated the adequacy of an spatially mobilized plane constitutive model and a modeling framework using laboratory‐induced dissociation tests under shear from literature. Using laboratory‐imposed temperature and pressure changes and the resulting hydrate saturation changes as input, this study was able to capture the geomechanical responses and determine the stability state of methane hydrate‐bearing sediments as observed. Copyright © 2017 John Wiley & Sons, Ltd.
Comparing anticholinergic persistence and adherence profiles in overactive bladder patients based on gender, obesity, and major anticholinergic agents
Authors: Lua Lannah L. , Pathak Prathamesh , Dandolu Vani 
Published: May 2017

AimsOveractive bladder (OAB) is highly prevalent particularly among obese patients and significantly impacts quality of life. Anticholinergics are the first‐line treatment. The effect of obesity on medication compliance has not been studied. Our study evaluated gender‐ and obesity‐specific adherence and persistence of anticholinergic medications in OAB. We also compared adherence and persistence on solifenacin to oxybutynin, tolterodine, and all anticholinergics combined.MethodsTruven Marketscan Commercial Claims and Encounter database from 2005 to 2013 was used. OAB patients aged 18‐65 continuously enrolled for ≥12 months pre‐ and post‐index were identified. Adherence was assessed by medication possession ratio (MPR) and proportion of days covered (PDC). Persistence was defined as number of days from anticholinergic initiation to discontinuation, switch, or end of study. Statistical analyses were performed using SAS 9.3.ResultsAmong 122 641 OAB patients, most common comorbidities were hypertension, depression, and diabetes; patients with these conditions were more compliant. Obese patients were 7% less likely to adhere and 6% more likely to become non‐persistent on anticholinergics compared to non‐obese. Males were 20% more likely to adhere to anticholinergics compared to females. Oxybutynin, solifenacin, and tolterodine were the most common anticholinergics. Solifenacin demonstrated higher adherence and persistence compared to all anticholinergics combined. The proportion of patients still on solifenacin at 1 year was 17.11%, compared to 12.64% for all anticholinergics combined.ConclusionsMen are more likely to be adherent to anticholinergics than women. Obese patients are less likely to be compliant to medications, possibly related to severity of symptoms. Solifenacin had the highest rates of patient compliance.
Secondary delay‐partition approach on robust performance analysis for uncertain time‐varying Lurie nonlinear control system
Authors: Shi Kaibo , Tang Yuanyan , Liu Xinzhi , Zhong Shouming 
Published: May 2017

SummaryThis paper investigates the problem of robust performance analysis for Lurie nonlinear control system with parameter uncertainties and interval time‐varying delays. Based on an augmented Lyapunov‐Krasovskii functional including multiple integral terms, new delay‐dependent robust stability criteria are derived by proposing a novel secondary delay‐partition approach. Moreover, to obtain less conservative stability conditions, an optimized integral inequality is developed by introducing an adjustable parameter ς1. Finally, 5 numerical simulation examples are given to illustrate the effectiveness and advantages of the proposed results.
Quaternized polysulfone‐based nanocomposite membranes and improved properties by intercalated layered double hydroxide
Authors: Liang Na , Liu Wan , Zuo Danying , Peng Pai , Qu Rong , Chen Dongzhi , Zhang Hongwei 
Published: May 2017

Two anions (dodecylbenzenesulfonate anion and stearate anion) are employed to synthesize intercalated layered double hydroxides (LDH) by co‐precipitation method. Then the intercalated LDHs are incorporated in the casting solutions of chloromethylated polysulfone (CMPSF) for fabricating quaternized polysulfone/LDH nanocomposite membranes. Fourier transform infrared, X‐ray diffraction, thermogravimetric analysis, scanning electron microscopy, and mastersizer laser particle size analysis are used to characterize the structure and morphology of LDHs and membranes. The properties of the composite membranes including water uptake, mechanical property, thermal stability, and ionic conductivity are investigated. Compared with other anion exchange membranes, both nanocomposite membranes containing 5% LDH sheets displayed better balanced performance. They exhibit the ionic conductivity of 3.58 × 10−2 S cm−1 and 3.86 × 10−2 S cm−1 at 60°C, respectively. POLYM. ENG. SCI., 2017. © 2017 Society of Plastics Engineers
A conserved regulatory mechanism in bifunctional biotin protein ligases
Authors: Wang Jingheng , Beckett Dorothy 
Published: May 2017

AbstractClass II bifunctional biotin protein ligases (BirA), which catalyze post‐translational biotinylation and repress transcription initiation, are broadly distributed in eubacteria and archaea. However, it is unclear if these proteins all share the same molecular mechanism of transcription regulation. In Escherichia coli the corepressor biotinoyl‐5′‐AMP (bio‐5′‐AMP), which is also the intermediate in biotin transfer, promotes operator binding and resulting transcription repression by enhancing BirA dimerization. Like E. coli BirA (EcBirA), Staphylococcus aureus, and Bacillus subtilis BirA (Sa and BsBirA) repress transcription in vivo in a biotin‐dependent manner. In this work, sedimentation equilibrium measurements were performed to investigate the molecular basis of this biotin‐responsive transcription regulation. The results reveal that, as observed for EcBirA, Sa, and BsBirA dimerization reactions are significantly enhanced by bio‐5′‐AMP binding. Thus, the molecular mechanism of the Biotin Regulatory System is conserved in the biotin repressors from these three organisms.
Make up a missed lesson‐New policy to ensure the interchangeability of generic drugs in China
Authors: Huang Baobin , Barber Sarah L. , Xu Mingzhe , Cheng Shuanghong 
Published: May 2017

AbstractGeneric drugs should be interchangeable with originators in terms of quality and efficacy. With relative lower prices, generic drugs are playing an important role in controlling health expenditures and ensuring access. However, the widespread understanding of “cheap price equals low quality” has a negative impact on the acceptance of generic drugs. In China, medical doctors doubt the efficacy and quality of generic drugs manufactured domestically. To address these concerns, the Chinese State Council released a policy in to ensure the interchangeability by re‐evaluating the quality and efficacy of generic drugs. It intends to make up a missed lesson in the regulation to be in line with internationally accepted practices. Generic drugs firms, depends on the availability of appropriate comparators, should conduct either comparative bioequivalence studies or full scale clinical trials. The re‐evaluation will be implemented in a stepwise approach with the essential medicines covered in the first step. The policy could achieve several benefits by increasing confidence on the Chinese produced generic drugs, upgrading regulatory standards, streamlining the Chinese generic drug industry and creating a healthy competition market. Nevertheless, enormous challenges remain in enlarging the capacity to review applications, selecting appropriate comparators, ensuring the capacity of domestic clinical research sites, and achieving the acceptance of re‐evaluated generic drugs.
Endoluminal surgical triangulation 2.0: A new flexible surgical robot. Preliminary pre‐clinical results with colonic submucosal dissection
Authors: Légner András , Diana Michele , Halvax Péter , Liu Yu‐Yin , Zorn Lucile , Zanne Philippe , Nageotte Florent , De Mathelin Michel , Dallemagne Bernard , Marescaux Jacques 
Published: May 2017

AbstractBackgroundComplex intraluminal surgical interventions of the gastrointestinal tract are challenging due to the limitation of existing instruments. Our group has developed a master–slave robotic flexible endoscopic platform that provides instrument triangulation in an endoluminal environment.Materials and MethodsColonic endoscopic submucosal dissections (ESD) were carried out in eight pigs. The robot was introduced transanally. A combination of adapted tele‐operated instruments was used. Specimens were inspected and measured.ResultsOut of 18 ESDs in total, 12 were successfully completed. Among the completed procedures, two perforations and one system failure occurred and were managed intraoperatively. There was no major bleeding. Mean size of the removed specimens was 18.2 ± 9.8 cm2 and mean total procedure time was 73 ± 35.5 min.ConclusionsExperimental colorectal ESDs using the flexible surgical robot were feasible and reflected a short learning curve. After some technical improvements the system might allow for a wider adoption of complex endoluminal surgical procedures.
Nonlinear–nonquadratic optimal and inverse optimal control for stochastic dynamical systems
Authors: Rajpurohit Tanmay , Haddad Wassim M. 
Published: May 2017

SummaryIn this paper, we develop a unified framework to address the problem of optimal nonlinear analysis and feedback control for nonlinear stochastic dynamical systems. Specifically, we provide a simplified and tutorial framework for stochastic optimal control and focus on connections between stochastic Lyapunov theory and stochastic Hamilton–Jacobi–Bellman theory. In particular, we show that asymptotic stability in probability of the closed‐loop nonlinear system is guaranteed by means of a Lyapunov function that can clearly be seen to be the solution to the steady‐state form of the stochastic Hamilton–Jacobi–Bellman equation and, hence, guaranteeing both stochastic stability and optimality. In addition, we develop optimal feedback controllers for affine nonlinear systems using an inverse optimality framework tailored to the stochastic stabilization problem. These results are then used to provide extensions of the nonlinear feedback controllers obtained in the literature that minimize general polynomial and multilinear performance criteria. Copyright © 2017 John Wiley & Sons, Ltd.
Durable Control of Autoimmune Diabetes in Mice Achieved by Intraperitoneal Transplantation of “Neo-Islets,” Three-Dimensional Aggregates of Allogeneic Islet and “Mesenchymal Stem Cells”
Authors: Westenfelder Christof , Gooch Anna , Hu Zhuma , Ahlstrom Jon , Zhang Ping 
Published: May 2017

Abstract
Novel interventions that reestablish endogenous insulin secretion and thereby halt progressive end-organ damage and prolong survival of patients with autoimmune Type 1 diabetes mellitus (T1DM) are urgently needed. While this is currently accomplished with allogeneic pancreas or islet transplants, their utility is significantly limited by both the scarcity of organ donors and life-long need for often-toxic antirejection drugs. Coadministering islets with bone marrow-derived mesenchymal stem cells (MSCs) that exert robust immune-modulating, anti-inflammatory, anti-apoptotic, and angiogenic actions, improves intrahepatic islet survival and function. Encapsulation of insulin-producing cells to prevent immune destruction has shown both promise and failures. Recently, stem cell-derived insulin secreting β-like cells induced euglycemia in diabetic animals, although their clinical use would still require encapsulation or anti-rejection drugs. Instead of focusing on further improvements in islet transplantation, we demonstrate here that the intraperitoneal administration of islet-sized “Neo-Islets” (NIs), generated by in vitro coaggregation of allogeneic, culture-expanded islet cells with high numbers of immuno-protective and cyto-protective MSCs, resulted in their omental engraftment in immune-competent, spontaneously diabetic nonobese diabetic (NOD) mice. This achieved long-term glycemic control without immunosuppression and without hypoglycemia. In preparation for an Food and Drug Administration-approved clinical trial in dogs with T1DM, we show that treatment of streptozotocin-diabetic NOD/severe combined immunodeficiency mice with identically formed canine NIs produced durable euglycemia, exclusively mediated by dog-specific insulin. We conclude that this novel technology has significant translational relevance for canine and potentially clinical T1DM as it effectively addresses both the organ donor scarcity (&gt;80 therapeutic NI doses/donor pancreas can be generated) and completely eliminates the need for immunosuppression.
Human Evolutionary Psychology
Authors: Barrett Louise , Dunbar Robin , Lycett John 
Published: May 2017

Why do people resort to plastic surgery to look young? Why are stepchildren at greatest risk of fatal abuse? Why do we prefer gossip to algebra? Why must Dogon wives live alone in a dark hut for five days a month? Why are young children good at learning language but not sharing? Over the past decade, psychologists and behavioral ecologists have been finding answers to such seemingly unrelated questions by applying an evolutionary perspective to the study of human behavior and psychology. Human Evolutionary Psychology is a comprehensive, balanced, and readable introduction to this burgeoning field. It combines a sophisticated understanding of the basics of evolutionary theory with a solid grasp of empirical case studies.
Covering not only such traditional subjects as kin selection and mate choice, this text also examines more complex understandings of marriage practices and inheritance rules and the way in which individual action influences the structure of societies and aspects of cultural evolution. It critically assesses the value of evolutionary explanations to humans in both modern Western society and traditional preindustrial societies. And it fairly presents debates within the field, identifying areas of compatibility among sometimes competing approaches.
Combining a broad scope with the more in-depth knowledge and sophisticated understanding needed to approach the primary literature, this text is the ideal introduction to the exciting and rapidly expanding study of human evolutionary psychology.
Keeping secrets from friends: Exploring the effects of friendship quality, loneliness and self‐esteem on secrecy
Authors: Corsano Paola , Musetti Alessandro , Caricati Luca , Magnani Barbara 
Published: May 2017

ABSTRACTThe tendency to keep secrets in adolescents has been studied in particular in their relationships with their parents and associated with psychosocial disadvantages. The current study focused on peer relationships and investigated the effects of friendship quality, loneliness in a multidimensional perspective, and self‐esteem on secrecy from friends. Italian adolescents (N = 457; 47% male; 100% white) aged between 13 and 19 years (M = 16.11; SD = 1.53) reported their secrecy from friends, peer and parent‐related loneliness, aversion and affinity for aloneness, their self‐esteem and the quality of their relationships with their friends. The results showed that peer‐related loneliness, affinity for aloneness and self‐esteem in particular affect keeping secrets from friends, independent of the participant's gender. Moreover, peer‐related loneliness and affinity for aloneness mediated the relationship between self‐esteem and secrecy. The data were discussed in the light of adolescence developmental tasks.
Patients’ Priorities Regarding Female-to-Male Gender Affirmation Surgery of the Genitalia—A Pilot Study of 47 Patients in Sweden
Authors: Jacobsson Josephine , Andréasson My , Kölby Lars , Elander Anna , Selvaggi Gennaro 
Published: May 2017

Abstract

Introduction
No surgical technique is reported to be the best option for gender-affirmation surgery (GAS) of the genitalia in transmen. Although patients’ preferences are central when choosing a surgical technique, no studies have evaluated this factor.

Aim
To investigate transmen’s priorities and preferences regarding GAS of the genitalia.

Methods
From November 2015 to March 2016, 54 transmen with the diagnosis of gender dysphoria who were referred to Sahlgrenska University Hospital for discussion of therapeutic steps (surgery and hormonal treatments) were asked to complete a questionnaire on different attributes achievable with GAS, such as sexual and urinary function and appearance. Forty-seven patients (87%) completed the questionnaire. Age ranged from 18 to 52 years (mean = 26 years, SD = 7.4 years). At the time of interview, no patient had undergone GAS of the genitalia.

Main Outcome Measures
Answers to completed questionnaires.

Results
Seventy-six percent of patients identified themselves as male, and 24% wrote other terms such as “mostly male,” “inter-gender” and “non-binary.” Gender identity had a significant impact on patients’ preferences for two questions: the importance of vaginal removal and the importance of having a penis that would be passable in places such as male dressing rooms. These items were more important to patients identifying themselves as male. The most important attributes requested were preserved orgasm ability and tactile sensation. The least important attribute was removal of the vagina, followed by having a penis of human material, minimal scarring, and size. The ability to urinate while standing was considered a high priority by some and a low priority by others. All answers ranged from “unimportant” to “imperative.”

Conclusion
This series of patients demonstrates a considerable heterogeneity among transmen in their gender identity and preferences regarding GAS of the genitalia, which supports the need for several techniques. Patients must be accurately informed on the different techniques and their specific benefits and limitations to make an informed choice.