bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cardiac
Stim1
Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling
Authors: Bénard Ludovic , Oh Jae Gyun , Cacheux Marine , Lee Ahyoung , Nonnenmacher Mathieu , Matasic Daniel S. , Kohlbrenner Erik , Kho Changwon , Pavoine Catherine , Hajjar Roger J. , Hulot Jean-Sébastien 
Published: April 2016

Background—
Stromal interaction molecule 1 (STIM1) is a dynamic calcium signal transducer implicated in hypertrophic growth of cardiomyocytes. STIM1 is thought to act as an initiator of cardiac hypertrophic response at the level of the sarcolemma, but the pathways underpinning this effect have not been examined.

Methods and Results—

To determine the mechanistic role of STIM1 in cardiac hypertrophy and during the transition to heart failure, we manipulated STIM1 expression in mice cardiomyocytes by using in vivo gene delivery of specific short hairpin RNAs. In 3 different models, we found that
Stim1
silencing prevents the development of pressure overload–induced hypertrophy but also reverses preestablished cardiac hypertrophy. Reduction in STIM1 expression promoted a rapid transition to heart failure. We further showed that
Stim1
silencing resulted in enhanced activity of the antihypertrophic and proapoptotic GSK-3β molecule. Pharmacological inhibition of glycogen synthase kinase-3 was sufficient to reverse the cardiac phenotype observed after
Stim1
silencing. At the level of ventricular myocytes,
Stim1
silencing or inhibition abrogated the capacity for phosphorylation of Akt
S473
, a hydrophobic motif of Akt that is directly phosphorylated by mTOR complex 2. We found that
Stim1
silencing directly impaired mTOR complex 2 kinase activity, which was supported by a direct interaction between STIM1 and Rictor, a specific component of mTOR complex 2.

Conclusions—
These data support a model whereby STIM1 is critical to deactivate a key negative regulator of cardiac hypertrophy. In cardiomyocytes, STIM1 acts by tuning Akt kinase activity through activation of mTOR complex 2, which further results in repression of GSK-3β activity.
Descriptions of the immature stages and new host plant records of Notozulia entreriana (Berg) (Hemiptera: Cercopidae) pests of grasses in subtropical areas of the Americas
Authors: FOIERI ALVARO , LENICOV ANA M. MARINO DE REMES , VIRLA EDUARDO G. 
Published: April 2016

Notozulia entreriana (Berg) (Hemiptera: Cercopidae) is one of the most common spittlebugs inhabiting the subtropical region of the America, inflicting important economic damage to grass crops. The immature stages are described and illustrated; the main characteristics that distinguish instars are the body size, color, number of flagellomeres, and number of tibial and metatarsomere spines. A key for identification of nymphs is provided as a tool to develop field studies. Nine host plants, all belonging to Poaceae, are recorded as breeding and feeding host plants from different localities in northern Argentina.
Modeling of Precipitable Water Vapor Using an Adaptive Neuro-Fuzzy Inference System in the Absence of the GPS Network
Authors: Suparta Wayan , Alhasa Kemal Maulana 
Published: April 2016

AbstractThis paper constructs an adaptive neuro-fuzzy inference system (ANFIS) model to estimate precipitable water vapor (PWV) in Southeast Asia, particularly in the Peninsular Malaysia, Sabah, and Singapore region. The input to the model is developed using the surface pressure, temperature, and relative humidity. The models are trained and tested using PWV values derived from the global positioning system (GPS). The data used are for May 2012 taken at the Nanyang Technology University of Singapore (NTUS) and Universiti Malaysia Sabah, Kinabalu (UMSK); and for February 2009 taken at the Universiti Kebangsaan Malaysia Bangi (UKMB). The validation process is conducted using June 2012 data for NTUS and UMSK and March 2009 data for UKMB. The performance the ANFIS model is compared with a multilayer perceptron (MLP), Elman neural networks, and multiple linear regression (MLR) models. Results from validations at the three stations showed that the ANFIS model performed well as compared with MLP, Elman neural networks, and MLR, with a mean absolute error of 0.015 mm, a percent error of 0.028%, and root-mean-square error of 0.019 mm. These results suggest that the ANFIS model is a promising approach for estimating PWV values that is cost effective, continuous, and potentially useful for meteorological applications.
Influence of the Summer NAO on the Spring-NAO-Based Predictability of the East Asian Summer Monsoon
Authors: Zheng Fei , Li Jianping , Li Yanjie , Zhao Sen , Deng Difei 
Published: April 2016

AbstractThe dominant mode of atmospheric circulation over the North Atlantic region is the North Atlantic Oscillation (NAO). The boreal spring NAO may imprint its signal on contemporaneous sea surface temperature (SST), leading to a North Atlantic SST tripolar pattern (NAST). This pattern persists into the following summer and modulates the East Asian summer monsoon (EASM). Previous studies have shown that the summer NAST is caused mainly by the preceding spring NAO, whereas the contemporaneous summer NAO plays a secondary role. The results of this study illustrate that, even if the summer NAO plays a secondary role, it may also perturb summer SST anomalies caused by the spring NAO. There are two types of perturbation caused by the summer NAO. If the spring and summer NAO patterns have the same (opposite) polarities, the summer NAST tends to be enhanced (reduced) by the summer NAO, and the correlation between the spring NAO and EASM is usually stronger (weaker). In the former (latter) case, the spring-NAO-based prediction of the EASM tends to have better (limited) skill. These results indicate that it is important to consider the evolution of the NAO when forecasting the EASM, particular when there is a clear reversal in the polarity of the NAO, because it may impair the spring-NAO-based EASM prediction.
Response of the Superparameterized Madden–Julian Oscillation to Extreme Climate and Basic-State Variation Challenges a Moisture Mode View
Authors: Pritchard Michael S. , Yang Da 
Published: April 2016

Abstract
The climate sensitivity of the Madden–Julian oscillation (MJO) is measured across a broad range of temperatures (1°–35°C) using a convection-permitting global climate model with homogenous sea surface temperatures. An MJO-like signal is found to be resilient in all simulations. These results are used to investigate two ideas related to the modern “moisture mode” view of MJO dynamics. The first hypothesis is that the MJO has dynamics analogous to a form of radiative convective self-aggregation in which longwave energy maintenance mechanisms shut down for SST ≪ 25°C. Inconsistent with this hypothesis, the explicitly simulated MJO survives cooling and retains leading moist static energy (MSE) budget terms associated with longwave destabilization even at SST &lt; 10°C. Thus, if the MJO is a form of longwave-assisted self-aggregation, it is not one that is temperature critical, as is observed in some cases of radiative–convective equilibrium (RCE) self-aggregation. The second hypothesis is that the MJO is propagated by horizontal advection of column MSE. Inconsistent with this view, the simulated MJO survives reversal of meridional moisture gradients in the basic state and a striking role for horizontal MSE advection in its propagation energy budget cannot be detected. Rather, its eastward motion is balanced by vertical MSE advection reminiscent of gravity or Kelvin wave dynamics. These findings could suggest a tight relation between the MJO and classic equatorial waves, which would tend to challenge moisture mode views of MJO dynamics that assume horizontal moisture advection as the MJO’s propagator. The simulation suite provides new opportunities for testing predictions from MJO theory across a broad climate regime.
The Uses and Impacts of Mobile Computing Technology in Hot Spots Policing
Authors: Koper Christopher S. , Lum Cynthia , Hibdon Julie 
Published: April 2016

Background: Recent technological advances have much potential for improving police performance, but there has been little research testing whether they have made police more effective in reducing crime. Objective: To study the uses and crime control impacts of mobile computing technology in the context of geographically focused “hot spots” patrols. Research Design: An experiment was conducted using 18 crime hot spots in a suburban jurisdiction. Nine of these locations were randomly selected to receive additional patrols over 11 weeks. Researchers studied officers’ use of mobile information technology (IT) during the patrols using activity logs and interviews. Nonrandomized subgroup and multivariate analyses were employed to determine if and how the effects of the patrols varied based on these patterns. Results: Officers used mobile computing technology primarily for surveillance and enforcement (e.g., checking automobile license plates and running checks on people during traffic stops and field interviews), and they noted both advantages and disadvantages to its use. Officers did not often use technology for strategic problem-solving and crime prevention. Given sufficient (but modest) dosages, the extra patrols reduced crime at the hot spots, but this effect was smaller in places where officers made greater use of technology. Conclusions: Basic applications of mobile computing may have little if any direct, measurable impact on officers’ ability to reduce crime in the field. Greater training and emphasis on strategic uses of IT for problem-solving and crime prevention, and greater attention to its behavioral effects on officers, might enhance its application for crime reduction.
Burrows and Burrs: A Perceptual History
Authors: Lee Tom 
Published: April 2016

Abstract
Knowledge has no proper homeland. It is scattered among disciplines and genres. A novel is filled with events, described in a particular manner, which might be translated into objects of scientific worth. Science makes new discoveries that find their way back into literature. Philosophy questions starting points and adds nuance to grey areas between disciplines. Science contributes to philosophy's repertoire of relevant ideas. This article is an effort to account for the dynamism and complexity of the relationship that exists between differing kinds of knowledge. It uses an essayistic form of narration to pull together contrasting examples that suggest hard and fast distinctions between subject and object tend to provoke misleadingly abstract descriptions of place. The specific place under investigation is a farming property in rural New South Wales. It has played a significant part in the author's perceptual history. Burrs and burrows are two of its key features.
‘Redneck, Barbaric, Cashed Up Bogan? I Don't Think So’: Hunting and Nature in Australia
Authors: Adams Michael 
Published: April 2016

AbstractHunting is a controversial activity in Australia, and much debated in international research. Positions range from ‘the first hunters were the first humans’ to the ‘meat is murder’ argument. There is, however, very little research on non-Indigenous hunting in Australia, particularly on the social aspects, but also on biological and ecological issues. In contrast to a general lack of research on non-Indigenous hunting, there is extensive literature on Indigenous hunting. This paper reviews initial research exploring hunting participation and motivation in Australia, as a window into further understanding connections between humans, non-humans and place. My focus is on an analysis of hunting as cultural involvement in nature. Is it a cruel, archaic and redundant practice; or a respectful relationship between and among humans and non-humans which can reorient us to our emerging recombinant ecologies?
On the Poverty of Our Nomenclature
Authors: Crist Eileen 
Published: April 2016

AbstractThis paper examines the recent proposal to christen our geological epoch “the Anthropocene.” The reasoning offered for this new name is that humanity's enormous mark on the geological strata would be a discernible boundary to future geologists; therefore a change in nomenclature is called for to reflect our transition out of the Holocene (our epoch's current formal name). I argue, however, that the pitch for the Anthropocene goes well beyond this rationale. The Anthropocene has morphed into a discourse that is organizing the perception of a world picture (past, present, and future) through a set of ideas and prescriptions that is tenaciously anthropocentric; indeed, the championed name itself—Anthropocene, or the age of Man—evokes the human-centeredness that is at the root of our ecological predicament. The main argument of this paper is that the discourse of the Anthropocene refuses to challenge human dominion, proposing instead technological and managerial approaches that would make human dominion sustainable. By the same token, the Anthropocene discourse blocks from consideration the possibility of abolishing a way of life founded on the domination of nature. In conclusion, I submit that while technological and managerial approaches have a place in addressing ecological problems, our predicament primarily calls for a drastic pulling back and scaling down of the human presence—welcoming limitations of our numbers, economies, forms of habitation, and uses of land and sea, so that humanity may flourish together with the entire breadth of Life.
Environmental Arts as First Philosophy: This Too a NeoPresocratic Manifesto
Authors: Greaves Tom 
Published: April 2016

Abstract
I offer a response and counter argument to J. Baird Callicott's “Provocations” piece in Environmental Humanities, volume 2. I argue that the historical narrative that Callicott derives from Aristotle regarding the development of philosophical thought from natural philosophy to social and moral concerns, is not the best way to conceive of the project of the Presocratics. Nor does this narrative offer us the best way to conceive of the distinctive tasks of the environmental arts (a term which I argue is to be preferred to the environmental humanities) and their relation to the sciences. I offer a different model, inspired by the Heraclitean notion of unity in opposition, which conceives the task of the arts as the common articulation of our myriad ways of being in the world and the task of the various sciences as the exploration of the world that is manifest in and through those ways of being. This model allows us to see how we might aim towards unity in opposition rather than a fusion of the two cultures. On this basis I make some proposals concerning the long-term and more immediate institutional and pedagogical consequences of this view and reflect upon the challenges facing my teaching on the UEA Master's in Environmental Sciences and Humanities.
The Orchid in the Land of Garbage: An Ecocritique of Terrence Malick's FilmBadlands(1973)
Authors: Blasi Gabriella 
Published: April 2016

AbstractThrough a figural analysis of Terrence Malick's Badlands (1973), this paper seeks to contribute to a more defined role of film criticism in contemporary environmental thought. The analysis focuses on the relation between humans and nature in Badlands and revolves around the ontological question of what it means to be free human beings in the world of nature, intended as a finite, temporal world. From an ecocritical perspective, Badlands' 1950s setting lends itself to a retrospective illumination of the forces that have contributed to the present problematic human-nature relation within “free” capitalist systems of thought and consumption. However, a figural analysis reveals that Malick's insistence on images of waste and death assumes a far more existential value, opening up possible deeper reflections beyond economic, social and political critiques.
The Last Chance to Save the Planet? An Analysis of the Geoengineering Advocacy Discourse in the Public Debate
Authors: Anshelm Jonas , Hansson Anders 
Published: April 2016

Abstract
Geoengineering, i.e., the deliberate manipulation of the global climate using grand-scale technologies, poses new challenges in terms of environmental risks and human–nature relationships. Until recently, these technologies were considered science fiction, but they are now being reconsidered by researchers, leading to an emerging public debate. Our aim is to improve our understanding of the public discourse on geoengineering in mass media. We analyze 1500 articles published from 2005 to 2013, constructing four coherent storylines that represent most of the geoengineering advocacy in the public discourse in mass media. We scrutinize inconsistencies in this discourse and argue that geoengineering may be the first example of a grand-scale technology that in some important respects has clear postmodern tendencies: geoengineering advocacy, for example, is not based on objective truth claims of the natural sciences and does not promise a better world.
Mapping Common Ground: Ecocriticism, Environmental History, and the Environmental Humanities
Authors: Bergthaller Hannes , Emmett Rob , Johns-Putra Adeline , Kneitz Agnes , Lidström Susanna , McCorristine Shane , Pérez Ramos Isabel , Phillips Dana , Rigby Kate , Robin Libby 
Published: April 2016

Abstract
The emergence of the environmental humanities presents a unique opportunity for scholarship to tackle the human dimensions of the environmental crisis. It might finally allow such work to attain the critical mass it needs to break out of customary disciplinary confines and reach a wider public, at a time when natural scientists have begun to acknowledge that an understanding of the environmental crisis must include insights from the humanities and social sciences. In order to realize this potential, scholars in the environmental humanities need to map the common ground on which close interdisciplinary cooperation will be possible. This essay takes up this task with regard to two fields that have embraced the environmental humanities with particular fervour, namely ecocriticism and environmental history. After outlining an ideal of slow scholarship which cultivates thinking across different spatiotemporal scales and seeks to sustain meaningful public debate, the essay argues that both ecocriticism and environmental history are concerned with practices of environing: each studies the material and symbolic transformations by which “the environment” is configured as a space for human action. Three areas of research are singled out as offering promising models for cooperation between ecocriticism and environmental history: eco-historicism, environmental justice, and new materialism. Bringing the fruits of such efforts to a wider audience will require environmental humanities scholars to experiment with new ways of organizing and disseminating knowledge.
Fasting blood glucose and newborn birth weight of non- diabetic Sudanese women
Authors: Elmugabil Abdelmageed , Rayis Duria A. , Adam Ishag , Lutfi Mohamed F. 
Published: April 2016

Background Although risk factors for abnormal birth weight has been extensively investigated, whether the physiological range of glucose tolerance affects birth weight in non-diabetic mothers needs to be verified by further research. Objectives To assess the effect of maternal sociodemographic characteristics, obstetric and anthropometric measurements, fasting and 2-hour blood glucose levels on birth weight. Methods One hundred and thirty four women were followed from early pregnancy until delivery at Saad Abualila Hospital, Khartoum, Sudan. Fasting and 2-hour glucose levels following administration of 75 g oral glucose was performed in the third trimester. Association between birth weight and maternal sociodemographic characteristics, obstetric and anthropometric measurements, haemoglobin, fasting and 2-hour blood glucose levels were assessed by linear regression analysis. Results The mean (SD) birth weight was 3127.7 (480.0) g, while the 10th and 90th centile were 2500 and 3800 g, respectively. There was no significant difference in the birth weight between male (n=73) and female (n=61) newborns [3167.8 (545.0) vs 3068.9 (384.0) g, P= 0.196]. Likewise there was no significant difference in the birth weight of newborns born to primipara and multipara mothers [3101.7 (529.0) g vs 3151.4 (432.0) g, P= 0.551]. Linear regression analysis demonstrated significant association between fasting blood glucose and birth weight (20 g, P = 0.028). None of the other maternal/fetal characteristics was associated with birth weight, including maternal age, body mass index, gravidity, weight gain during pregnancy, interpregnancy interval, history of miscarriage, haemoglobin level, blood pressure, fetal gender and gestational age. Conclusion In this study fasting blood glucose was found to be predictor of birth weight among neonates of non-diabetic Sudanese mothers.
Caracterización de parámetros fisicoquímicos en frutos de mora (Rubus alpinus Macfad)
Authors: Moreno Brigitte Liliana , Deaquiz Oyola Yuli Alexandra 
Published: April 2016

La mora (<em>Rubus alpinus</em> Macfad) es un cultivo agrícola rentable para pequeños productores que no cuenta con herramientas tecnológicas poscosecha suficientes, que les permite ser más competitivos en el merca-do nacional e internacional. En el trabajo se evaluaron parámetros fisicoquímicos de frutos de mora en un diseño factorial 4 x 2 con cuatro repeticiones donde el primer factor correspondió a las fincas de culti-vo y el segundo a los grados de madurez. Se midieron las variables pH, sólidos solubles totales, acidez total titulable, índice de madurez, firmeza, diámetro y longitud del fruto. Se encontró que los estados de madurez, las condiciones edafoclimáticas de la zona y el manejo agronómico influyen directamente sobre las características fisicoquímicas del fruto, siendo el estado de madurez grado 6 el que presenta las carac-terísticas organolépticas optimas de consumo y procesamiento del fruto en fresco.
Efecto de la aplicación de riego controlado en la producción y calidad del fruto de Pyrus communis L., cv. Triunfo de Viena
Authors: Díaz Abril Diana Milena , Velez Sánchez Javier Enrique , Rodriguez Hernández Pedro 
Published: April 2016

En Colombia, las áreas de siembra en pera (<em>Pyrus communis</em> L.) han incrementado en los últimos años, debido a las ventajas nutricionales y medicinales que presenta el consumo de esta fruta. En el estudio se evaluó el efecto de la reducción de riego durante la etapa de crecimiento rápido del fruto en la producción y calidad del cultivar Triunfo de Viena de pera, con el fin de implementar estrategias para una mayor efi-ciencia de la utilización de agua durante los periodos fenológicos del cultivo. La investigación se realizó en 2012 y 2013 en árboles de pera de 16 años de edad en el municipio de Sesquilé, Cundinamarca (Colom-bia) aplicando tres tratamientos de riego: (1) control (T1) = aplicación de riego equivalente al 100% de la (evaporación del cultivo) (ETc) durante todo el ciclo de producción, (T2) = aplicación de riego equivalente a 73% de la ETc durante el periodo de crecimiento rápido del fruto, y (T3) = aplicación de riego equivalente a 53% de la ETc durante el mismo periodo T2. El diseño experimental fue bloques completos al azar con cuatro repeticiones por tratamiento y los resultados fueron sometidos a análisis de varianza (Anova) y prueba de comparación de medias de Duncan (P &lt; 0.05). La reducción de riego equivalente a 53% de la ETc en época de sequía no afecto la producción ni la calidad del fruto, lo que permitió un ahorro de 47% de agua en esta etapa de crecimiento del fruto cuando se requiere aplicación de riego.