bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of bioenergy and biochemicals in CO2 mitigation through the energy system – a scenario analysis for the Netherlands
Authors: Tsiropoulos Ioannis , Hoefnagels Ric , van den Broek Machteld , Patel Martin K. , Faaij Andre P. C. 
Published: March 2017

AbstractBioenergy as well as bioenergy with carbon capture and storage are key options to embark on cost‐efficient trajectories that realize climate targets. Most studies have not yet assessed the influence on these trajectories of emerging bioeconomy sectors such as biochemicals and renewable jet fuels (RJFs). To support a systems transition, there is also need to demonstrate the impact on the energy system of technology development, biomass and fossil fuel prices. We aim to close this gap by assessing least‐cost pathways to 2030 for a number of scenarios applied to the energy system of the Netherlands, using a cost‐minimization model. The type and magnitude of biomass deployment are highly influenced by technology development, fossil fuel prices and ambitions to mitigate climate change. Across all scenarios, biomass consumption ranges between 180 and 760 PJ and national emissions between 82 and 178 Mt CO2. High technology development leads to additional 100–270 PJ of biomass consumption and 8–20 Mt CO2 emission reduction compared to low technology development counterparts. In high technology development scenarios, additional emission reduction is primarily achieved by bioenergy and carbon capture and storage. Traditional sectors, namely industrial biomass heat and biofuels, supply 61–87% of bioenergy, while wind turbines are the main supplier of renewable electricity. Low technology pathways show lower biochemical output by 50–75%, do not supply RJFs and do not utilize additional biomass compared to high technology development. In most scenarios the emission reduction targets for the Netherlands are not met, as additional reduction of 10–45 Mt CO2 is needed. Stronger climate policy is required, especially in view of fluctuating fossil fuel prices, which are shown to be a key determinant of bioeconomy development. Nonetheless, high technology development is a no‐regrets option to realize deep emission reduction as it also ensures stable growth for the bioeconomy even under unfavourable conditions.
Susceptibility loci for metabolic syndrome and metabolic components identified in Han Chinese: a multi‐stage genome‐wide association study
Authors: Zhu Yimin , Zhang Dandan , Zhou Dan , Li Zhenli , Li Zhiqiang , Fang Le , Yang Min , Shan Zhongyan , Li Hong , Chen Jianhua , Zhou Xianghai , Ye Wei , Yu Senhai , Li Huabin , Cai Libin , Liu Chengguo , Zhang Jie , Wang Lixin , Lai Yaxin , Ruan Liansheng , Sun Zhanhang , Zhang Shuai , Wang Hao , Liu Yi , Xu Yuyang , Ling Jie , Xu Chunxiao , Zhang Yan , Lv Duo , Yuan Zheping , Zhang Jing , Zhang Yingqi , Shi Yongyong , Lai Maode 
Published: March 2017

AbstractMetabolic syndrome (MetS), a cluster of metabolic disturbances that increase the risk for cardiovascular disease and diabetes, was because of genetic susceptibility and environmental risk factors. To identify the genetic variants associated with MetS and metabolic components, we conducted a genome‐wide association study followed by replications in totally 12,720 participants from the north, north‐eastern and eastern China. In combined analyses, independent of the top known signal at rs651821 on APOA5, we newly identified a secondary triglyceride‐associated signal at rs180326 on BUD13 (Pcombined = 2.4 × 10−8). Notably, by an integrated analysis of the genotypes and the serum levels of APOA5, BUD13 and triglyceride, we observed that BUD13 was another potential mediator, besides APOA5, of the association between rs651821 and serum triglyceride. rs671 (ALDH2), an east Asian‐specific common variant, was found to be associated with MetS (Pcombined = 9.7 × 10−22) in Han Chinese. The effects of rs671 on metabolic components were more prominent in drinkers than in non‐drinkers. The replicated loci provided information on the genetic basis and mechanisms of MetS and metabolic components in Han Chinese.
Dyadic incongruence in chronic heart failure: Implications for patient and carer psychological health and self‐care
Authors: Cameron Jan , Thompson David R , Szer Dion , Greig Johanna , Ski Chantal F 
Published: March 2017

Aims and objectivesTo examine whether chronic heart failure patient–carer dyads who disagree about the division of illness management tasks (incongruent) experience poorer psychosocial health and self‐care, than those who agree (congruent).BackgroundInformal carers often assist patients with chronic heart failure in the complex management of their illness, but little is known about how relationship dynamics may affect psychosocial health.DesignA prospective cross‐sectional study was adopted with a purposeful sample of 25 chronic heart failure patient–carer dyads residing in Australia.MethodsData were collected via mail‐out questionnaires. Dyads were classified as congruent or incongruent using the Heart Failure Care Assessment Scale. Depression, anxiety, stress and quality of life were assessed in patients and carers. Additionally, self‐care and relationship quality were assessed in patients; and burden and esteem were assessed in carers. Differences in congruent and incongruent patient and carer outcomes were examined.ResultsDyads were predominantly spousal and around a third demonstrated incongruence. No significant differences were found between congruent (n = 16) and incongruent (n = 9) dyads, although patients in incongruent dyads tended to have been diagnosed more recently.ConclusionIn chronic heart failure patient–carer dyads incongruence exists even for patients with relatively mild chronic heart failure symptoms. These findings indicate that dyadic incongruence in illness management might not affect high‐functioning chronic heart failure heart failure patients or their carers.Relevance to clinical practiceGiven the prevalence of dyadic incongruence and the possibility of further negative outcomes with disease progression, it is important to examine factors such as length of time since diagnosis or type of carer relationship. By implementing self‐care education and management strategies that focus on the dyad, rather than the individual, nurses have the potential to improve both patient and carer outcomes.
Varieties of Participation in Public Services: The Who, When, and What of Coproduction
Authors: Nabatchi Tina , Sancino Alessandro , Sicilia Mariafrancesca 
Published: March 2017

AbstractDespite an international resurgence of interest in coproduction, confusion about the concept remains. This article attempts to make sense of the disparate literature and clarify the concept of coproduction in public administration. Based on some definitional distinctions and considerations about who is involved in coproduction, when in the service cycle it occurs, and what is generated in the process, the article offers and develops a typology of coproduction that includes three levels (individual, group, collective) and four phases (commissioning, design, delivery, assessment). The levels, phases, and typology as a whole are illustrated with several examples. The article concludes with a discussion of implications for research and practice.
Simultaneous genotyping of human platelet alloantigen‐1 to 28bw systems by multiplex polymerase chain reaction sequence‐based typing
Authors: Hong X. , Chen S. , Ying Y. , Liu Y. , Xu X. , He J. , Zhu F. 
Published: March 2017

Background and ObjectivesHuman platelet alloantigen (HPA) genotyping is important for the diagnosis and prevention the alloimmune platelet disorders. In this study, a simultaneous genotyping method for HPA‐1 to ‐28bw systems was established using multiplex PCR‐SBT and the frequencies of genotypes and alleles of HPA‐1 to ‐28bw systems in the Zhejiang Han population were analysed.Materials and MethodsThe specific primers were designed according to the nucleotide sequences of HPA‐1 to 28bw systems which are located in ITGB3, GP1BA, ITGA2B, ITGA2, GP1BB and CD109, respectively. The multiplex PCR amplification systems were used, and then, the amplicons were purified and sequenced. A total of 335 healthy volunteer blood donors were detected.ResultsThe genotypes of ten reference samples from Platelet Immunology Workshop of ISBT were in concordance with the known genotypes. Among the 28 HPA systems, HPA a and b alleles were found in HPA‐1 to 6w, HPA‐15 and HPA‐21w systems in the Chinese Han population, while only HPA aa genotype was detected in the other HPA systems. The frequencies of HPA‐1a and HPA‐1b were 0·993 and 0·007, with 0·943 and 0·057 for HPA‐2a and HPA‐2b, 0·527 and 0·473 for HPA‐3a and HPA‐3b, 0·997 and 0·003 for HPA‐4a and HPA‐4b, 0·991 and 0·009 for HPA‐5a and HPA‐5b, 0·980 and 0·020 for HPA‐6wa and HPA‐6wb, 0·508 and 0·492 for HPA‐15a and HPA‐15b and 0·994 and 0·006 for HPA‐21wa and HPA‐21wb.ConclusionsOne multiplex PCR‐SBT method for HPAs was established and the data of the study could help to prevent and treat for alloimmune thrombocytopenia.
Draft Genome Sequences of Pseudomonas moraviensis UCD-KL30, Vibrio ostreicida UCD-KL16,
Colwellia
sp. Strain UCD-KL20,
Shewanella
sp. Strain UCD-KL12, and
Shewanella
sp. Strain UCD-KL21, Isolated from Seagrass
Authors: Lujan Karley M. , Eisen Jonathan A. , Coil David A. 
Published: March 2017

ABSTRACT

Here, we present the draft genome sequences for five bacterial strains. These strains were all isolated from seagrass (
Zostera marina
) collected from Bodega Bay, CA, as a part of an undergraduate research project focused on seagrass-associated microbes.
Whole-Genome Sequence of Pseudomonas fluorescens EK007-RG4, a Promising Biocontrol Agent against a Broad Range of Bacteria, Including the Fire Blight Bacterium Erwinia amylovora
Authors: Habibi Roghayeh , Tarighi Saeed , Behravan Javad , Taheri Parissa , Kjøller Annelise Helene , Brejnrod Asker , Madsen Jonas Stenløkke , Sørensen Søren Johannes 
Published: March 2017

ABSTRACT

Here, we report the first draft whole-genome sequence of
Pseudomonas fluorescens
strain EK007-RG4, which was isolated from the phylloplane of a pear tree.
P. fluorescens
EK007-RG4 displays strong antagonism against
Erwinia amylovora
, the causal agent for fire blight disease, in addition to several other pathogenic and non-pathogenic bacteria.
Complete Genome Sequence of Carbapenem-Resistant Klebsiella pneumoniae Strain 1756, Isolated from a Pus Specimen
Authors: Kao Cheng-Yen , Yan Jing-Jou , Lin Yu-Chun , Zheng Po-Xing , Wu Jiunn-Jong 
Published: March 2017

ABSTRACT

Carbapenem-resistant
Klebsiella pneumoniae
strain 1756 was isolated from a pus specimen from a Taiwanese patient. Here, the complete genome sequence of strain 1756 is presented.
First Complete Genome Sequence of Corynebacterium riegelii
Authors: Greninger Alexander L. , Streithorst Jessica , Chiu Charles Y. , Miller Steve 
Published: March 2017

ABSTRACT

Here, we report the first complete genome sequence of
Corynebacterium riegelii
strain PUDD_83A45, isolated from the urine of a patient with urinary tract infection. The genome measured 2.56 Mb and contained no plasmid.
Complete Genome Sequence of Lactobacillus fermentum MTCC 25067 (Formerly TDS030603), a Viscous Exopolysaccharide-Producing Strain Isolated from Indian Fermented Milk
Authors: Aryantini Ni Putu Desy , Prajapati Jashbhai B. , Urashima Tadasu , Fukuda Kenji 
Published: March 2017

ABSTRACT

Lactobacillus fermentum
MTCC 25067 (formerly TDS030603) is capable of producing a highly viscous slime exopolysaccharide. We report here the complete genome sequence of the strain, which was deciphered by using PacBio single-molecule real-time sequencing technology.
Genome Sequence of Escherichia coli Tailed Phage Utah
Authors: Leavitt Justin C. , Heitkamp Alexandra J. , Bhattacharjee Ananda S. , Gilcrease Eddie B. , Casjens Sherwood R. 
Published: March 2017

ABSTRACT

Escherichia coli
bacteriophage Utah is a member of the chi-like tailed phage cluster in the
Siphoviridae
family. We report here the complete 59,024-bp sequence of the genome of phage Utah.
Draft Genome Sequence of the Pelagic Photoferrotroph
Chlorobium phaeoferrooxidans
Authors: Crowe Sean A. , Hahn Aria S. , Morgan-Lang Connor , Thompson Katherine J. , Simister Rachel L. , Llirós Marc , Hirst Martin , Hallam Steven J. 
Published: March 2017

ABSTRACT

Here, we report the draft genome sequence of
Chlorobium phaeoferrooxidans
, a photoferrotrophic member of the genus
Chlorobium
in the phylum
Chlorobi
. This genome sequence provides insight into the metabolic capacity that underpins photoferrotrophy within low-light-adapted pelagic
Chlorobi
.
Complete Genome Sequence of a Novel Human Betapapillomavirus Isolated from a Skin Sample
Authors: Dutta Sankhadeep , Robitaille Alexis , Rollison Dana E. , Tommasino Massimo , Gheit Tarik 
Published: March 2017

ABSTRACT

We report the genetic characterization of a new papillomavirus (HPV_MTS1) isolated and fully cloned from a skin swab. The L1 open reading frame of HPV_MTS1 was 85% identical to its closest human papillomavirus (HPV) type 80, which belongs to the species beta-2 of the genus
Betapapillomavirus
, hence qualifying it as a new HPV type.
Emerging Fungal Threats to Plants and Animals Challenge Agriculture and Ecosystem Resilience
Authors: Fones Helen N. , Fisher Matthew C. , Gurr Sarah J. 
Published: March 2017

ABSTRACTWhile fungi can make positive contributions to ecosystems and agro-ecosystems, for example, in mycorrhizal associations, they can also have devastating impacts as pathogens of plants and animals. In undisturbed ecosystems, most such negative interactions will be limited through the coevolution of fungi with their hosts. In this article, we explore what happens when pathogenic fungi spread beyond their natural ecological range and become invasive on naïve hosts in new ecosystems. We will see that such invasive pathogens have been problematic to humans and their domesticated plant and animal species throughout history, and we will discuss some of the most pressing fungal threats of today.
DNA Replication in
Mycobacterium tuberculosis
Authors: Ditse Zanele , Lamers Meindert H. , Warner Digby F. 
Published: March 2017

ABSTRACT

Faithful replication and maintenance of the genome are essential to the ability of any organism to survive and propagate. For an obligate pathogen such as
Mycobacterium tuberculosis
that has to complete successive cycles of transmission, infection, and disease in order to retain a foothold in the human population, this requires that genome replication and maintenance must be accomplished under the metabolic, immune, and antibiotic stresses encountered during passage through variable host environments. Comparative genomic analyses have established that chromosomal mutations enable
M. tuberculosis
to adapt to these stresses: the emergence of drug-resistant isolates provides direct evidence of this capacity, so too the well-documented genetic diversity among
M. tuberculosis
lineages across geographic loci, as well as the microvariation within individual patients that is increasingly observed as whole-genome sequencing methodologies are applied to clinical samples and tuberculosis (TB) disease models. However, the precise mutagenic mechanisms responsible for
M. tuberculosis
evolution and adaptation are poorly understood. Here, we summarize current knowledge of the machinery responsible for DNA replication in
M. tuberculosis
, and discuss the potential contribution of the expanded complement of mycobacterial DNA polymerases to mutagenesis. We also consider briefly the possible role of DNA replication—in particular, its regulation and coordination with cell division—in the ability of
M. tuberculosis
to withstand antibacterial stresses, including host immune effectors and antibiotics, through the generation at the population level of a tolerant state, or through the formation of a subpopulation of persister bacilli—both of which might be relevant to the emergence and fixation of genetic drug resistance.
Relationship between diabetic nephropathy and depression: a cross-sectional analysis using the Diabetes Study from the Center of Tokyo Women's Medical University (DIACET)
Authors: Takasaki Keiko , Babazono Tetsuya , Ishizawa Kaya , Miura Junnosuke , Uchigata Yasuko 
Published: March 2017

ObjectiveWe conducted this cross-sectional study to investigate the relationship between stage of diabetic nephropathy and likelihood or severity of depression in patients with diabetes.Research design and methodsWe studied 2212 patients with diabetes (mean age 60.9 years; 928 women; 1838 patients with type 2 diabetes). Presence and severity of depression was examined using the Patient Health Questionnaire-9 (PHQ-9). Patients were classified into 5 stages of nephropathy, according to albuminuria and estimated glomerular filtration rate (eGFR); patients in stage 5 undergoing dialysis and kidney transplantation were analyzed separately (stages 5D and 5T). The relationship between stage of nephropathy and depression was examined using analysis of covariance and multivariate logistic regression analysis.ResultsBoth least square mean PHQ-9 scores and prevalence of patients with PHQ-9 scores ≥5 points (mild depression) and ≥10 points (moderate or severe depression) increased from stage 1 to 5D, and then declined in stage 5T. Multivariate ORs for mild or greater depression increased in patients in stages 3, 4, and 5D in reference to those in stage 1, which declined in patients in stage 5T. Albuminuria was significantly, but eGFR was not, associated with higher PHQ-9 scores and the PHQ-9 scores ≥5 or ≥10 after adjustment for clinical findings.ConclusionsIn patients with diabetes, progression of nephropathy is likely to be associated with increased risk and severity of depression, which may be reduced after successful kidney transplantation. Albuminuria may be more strongly associated with depression than eGFR.
Linking medical and dental health record data: a partnership with the Rochester Epidemiology Project
Authors: St. Sauver Jennifer L , Carr Alan B , Yawn Barbara P , Grossardt Brandon R , Bock-Goodner Cynthia M , Klein Lori L , Pankratz Joshua J , Finney Rutten Lila J , Rocca Walter A 
Published: March 2017

PurposeThe purpose of this project was to expand the Rochester Epidemiology Project (REP) medical records linkage infrastructure to include data from oral healthcare providers. The goal of this linkage is to facilitate research studies examining the role of oral health in overall health and quality of life.ParticipantsEight dental practices joined the REP between 2011 and 2015. The REP study team has linked oral healthcare information with medical record information from local healthcare providers for 31 750 participants who have resided in Olmsted County, Minnesota. Overall, 17 718 (56%) participants are women, 14 318 (45%) are 40 years of age or older and 26 090 (82%) are white.Findings to dateA first study using this new information was recently completed. This resource was used to determine whether the 2007 guidelines from the American Heart Association affected prescription rates of antibiotics to patients with moderate-risk cardiac conditions prior to dental procedures. The REP infrastructure was used to identify a series of patients diagnosed with moderate-risk cardiac conditions by the local healthcare providers (n=1351), and to abstract antibiotic prescriptions from dental records both pre-2007 and post-2007. Antibiotic prescriptions prior to dental procedures declined from 62% to 7% following the change in guidelines.Future plansDental data from participating practitioners will be updated on an annual basis, and new dental data will be linked to patient medical records. In addition, we will continue to invite new dental practices to participate in the REP. Finally, we will continue to use this research infrastructure to investigate associations between oral and medical health, and will present findings at conferences and in the scientific literature.
Instruments measuring the disease-specific quality of life of family carers of people with neurodegenerative diseases: a systematic review
Authors: Page Thomas E , Farina Nicolas , Brown Anna , Daley Stephanie , Bowling Ann , Basset Thurstine , Livingston Gill , Knapp Martin , Murray Joanna , Banerjee Sube 
Published: March 2017

ObjectiveNeurodegenerative diseases, such as dementia, have a profound impact on those with the conditions and their family carers. Consequently, the accurate measurement of family carers' quality of life (QOL) is important. Generic measures may miss key elements of the impact of these conditions, so using disease-specific instruments has been advocated. This systematic review aimed to identify and examine the psychometric properties of disease-specific outcome measures of QOL of family carers of people with neurodegenerative diseases (Alzheimer's disease and other dementias; Huntington's disease; Parkinson's disease; multiple sclerosis; and motor neuron disease).DesignSystematic review.MethodsInstruments were identified using 5 electronic databases (PubMed, PsycINFO, Web of Science, Scopus and the International Bibliography of the Social Sciences (IBSS)) and lateral search techniques. Only studies which reported the development and/or validation of a disease-specific measure for adult family carers, and which were written in English, were eligible for inclusion. The methodological quality of the included studies was evaluated using the COnsensus based Standards for the selection of health Measurement Instruments (COSMIN) checklist. The psychometric properties of each instrument were examined.Results676 articles were identified. Following screening and lateral searches, a total of 8 articles were included; these reported 7 disease-specific carer QOL measures. Limited evidence was available for the psychometric properties of the 7 instruments. Psychometric analyses were mainly focused on internal consistency, reliability and construct validity. None of the measures assessed either criterion validity or responsiveness to change.ConclusionsThere are very few measures of carer QOL that are specific to particular neurodegenerative diseases. The findings of this review emphasise the importance of developing and validating psychometrically robust disease-specific measures of carer QOL.