bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linear modal instabilities of hypersonic flow over an elliptic cone
Authors: Paredes Pedro , Gosse Ryan , Theofilis Vassilis , Kimmel Roger 
Published: September 2016

Steady laminar flow over a rounded-tip $2\,:\,1$ elliptic cone of 0.86 m length at zero angle of attack and yaw has been computed at Mach number $7.45$ and unit Reynolds number $Re^{\prime }=1.015\times 10^{7}~\text{m}^{-1}$. The flow conditions are selected to match the planned flight of the Hypersonic Flight Research Experimentation HIFiRE-5 test geometry at an altitude of 21.8 km. Spatial linear BiGlobal modal instability analysis of this flow has been performed at selected streamwise locations on planes normal to the cone symmetry axis, resolving the entire flow domain in a coupled manner while exploiting flow symmetries. Four amplified classes of linear eigenmodes have been unravelled. The shear layer formed near the cone minor-axis centreline gives rise to amplified symmetric and antisymmetric centreline instability modes, classified as shear-layer instabilities. At the attachment line formed along the major axis of the cone, both symmetric and antisymmetric instabilities are also discovered and identified as boundary-layer second Mack modes. In both cases of centreline and attachment-line modes, symmetric instabilities are found to be more unstable than their antisymmetric counterparts. Furthermore, spatial BiGlobal analysis is used for the first time to resolve oblique second modes and cross-flow instabilities in the boundary layer between the major- and minor-axis meridians. Contrary to predictions for the incompressible regime for swept infinite wing flow, the cross-flow instabilities are not found to be linked to the attachment-line instabilities. In fact, cross-flow modes peak along most of the surface of the cone, but vanish towards the attachment line. On the other hand, the leading oblique second modes peak near the leading edge and their associated frequencies are in the range of the attachment-line instability frequencies. Consequently, the attachment-line instabilities are observed to be related to oblique second modes at the major-axis meridian. The linear amplification of centreline and attachment-line instability modes is found to be strong enough to lead to laminar–turbulent flow transition within the length of the test object. The predictions of global linear theory are compared with those of local instability analysis, also performed here under the assumption of locally parallel flow, where use of this assumption is permissible. Fair agreement is obtained for symmetric centreline and symmetric attachment-line modes, while for all other classes of linear disturbances use of the proposed global analysis methodology is warranted for accurate linear instability predictions.
Validity of a web-based dietary questionnaire designed especially to measure the intake of phyto-oestrogens
Authors: Nybacka Sanna , Bertéus Forslund Heléne , Hedelin Maria 
Published: September 2016

AbstractA diet questionnaire (DQ) designed to assess habitual diet and phyto-oestrogen intake was developed. This study aimed to examine the validity of the DQ in men, with and without having prostate cancer. The DQ was validated against alkylresorcinol metabolites measured in urine as objective biomarkers of whole grain wheat and rye (WG) intake, and a 4-d estimated food record (FR) was used for relative comparison. Participants (n 61) completed both methods and provided spot urine samples. We found a statistically significant correlation between the DQ and FR for reported whole grain intake and isoflavonoids, as well as for intake of macronutrients, except protein. The correlation coefficient between the two methods was on average r 0·30, lowest for lignans (r −0·11) and highest for alcohol (r 0·65). Reported energy intake was lower in the DQ compared with FR (8523 v. 9249 kJ (2037 v. 2211 kcal), respectively; P = 0·014). Bland–Altman plots showed an acceptable agreement; most cases were within the limits (95 % CI) of agreement on reported energy intake, as well as intake of macronutrients, except protein (which was underestimated in the DQ compared with the FR). The correlation of alkylresorcinol with WG intake was statistically significant in the DQ (r 0·31, P = 0·015), but not in the FR (r 0·18, P = 0·12) and the weighted κ was 0·29 and 0·11, respectively. In conclusion, the results showed that the DQ have a reasonable validity for measuring WG intake and most nutrients, and, after some adjustments regarding protein intake assessment have been made, the DQ will be a promising tool.
Soya milk exerts different effects on plasma amino acid responses and incretin hormone secretion compared with cows’ milk in healthy, young men
Authors: Sun Lijuan , Tan Kevin Wei Jie , Siow Phei Ching , Henry Christiani Jeyakumar 
Published: September 2016

AbstractApart from the well-known action of insulin, the mechanism by which soya and cows’ milk improve postprandial glycaemia control was examined. In total, twelve healthy, young, Chinese men were studied on three separate occasions, in random order with isovolumetric (322 ml) control water, soya milk and cows’ milk. Plasma total amino acid concentrations increased 30 min after test meals consumption and were higher after soya milk (230 %) and cow milk (240 %) consumption compared with water. Cows’ milk ingestion induced higher branched-chain amino acids (BCAA) (40 %) than soya milk. Postprandial incretin concentrations increased after meal consumption. Cows’ milk meal was accompanied by higher incremental AUC (iAUC) (170 %) for glucagon-like peptide-1 (GLP-1) compared with soya milk and control (P=0·06). However, glucose-dependent insulinotropic polypeptide (GIP) concentrations increased to significantly greater levels after soya milk consumption (iAUC 60 % higher) compared with cows’ milk and control. Consumption of both soya and cows’ milk with carbohydrates induced a similar reduction in glycaemic response through a different mechanism, beyond insulin action. Plasma amino acids (alanine and arginine), and incretins in particular (GIP was stimulated), may be involved in the hyperinsulinaemia after soya milk meals. However, BCAA and GLP-1 release may be responsible for the reduced glycaemia after cows’ milk consumption by delaying gastric emptying. This could be the result of different milk protein/amino acid composition, but also differences in milk carbohydrate composition (i.e. lactose v. sucrose). It can be concluded that soya milk is a good alternative to cows’ milk with regard to glycaemic regulation, with different mechanisms involved.
Fasciolosis in South America: epidemiology and control challenges
Authors: Carmona C. , Tort J.F. 
Published: September 2016

AbstractFasciolosis caused byFasciola hepaticaseverely affects the efficiency of livestock production systems worldwide. In addition to the economic impact inflicted on livestock farmers, fasciolosis is an emergent zoonosis. This review emphasizes different aspects of the disease in South America. Available data on epidemiology in bovines and ovines in different countries, as well as a growing body of information on other domestic and wildlife definitive hosts, are summarized. The issue of drug resistance that compromises the long-term sustainability of current pharmacological strategies is examined from a regional perspective. Finally, efforts to develop a single-antigen recombinant vaccine in ruminants are reviewed, focusing on the cases of leucine aminopeptidase or thioredoxin glutathione reductase.
Effectiveness of the removal of coral-eating predator Acanthaster planci in Pulau Tioman Marine Park, Malaysia
Authors: Chak Solomon T. C. , Dumont Clement P. , Adzis Kee-Alfian Abd. , Yewdall Katie 
Published: September 2016

Population outbreaks of the coral-eating predator crown of thorns starfish (COTS), Acanthaster planci are responsible for large-scale disturbance of coral reefs throughout the Indo-Pacific. In response, attempts are often made to control COTS outbreaks in protected areas. For instance, volunteers remove thousands of sea stars every year in Malaysia. This study reports the status of the COTS population in the Pulau Tioman Marine Park and examines the effectiveness of the seasonal sea star removal programme. After the 2009 removal season, we monitored COTS densities and coral assemblages before and after a 6-month no-removal season at sites with and without COTS removal efforts. We recorded high COTS densities up to 330 ind. ha−1 at a few sites independent of removal effort. In fact, removal only temporarily reduced large individuals from local populations. Moreover, after the no-removal season, sites with COTS removal had increased live coral cover, but sites without COTS removal had a drastic decrease in live coral cover, with Acropora spp. being most affected. Therefore, this study suggests that the current seasonal removals could promote coral health, despite the high density of COTS.
Novel genotype ofTritrichomonas foetusfrom cattle in Southern Africa
Authors: CASTERIANO ANDREA , MOLINI UMBERTO , KANDJUMBWA KORNELIA , KHAISEB SIEGFRIED , FREY CAROLINE F. , ŠLAPETA JAN 
Published: September 2016

SUMMARYBovine trichomonosis caused byTritrichomonas foetusis a significant reproductive disease of cattle. Preputial samples were collected using sheath washing technique in bulls in Namibia. Thirty-six trichomonad cultures were characterized using the TaqMan-probe commercial real-time polymerase chain reaction (PCR) diagnostic assay (VetMAX™-Gold Trich Detection Kit) and CYBR real-time PCR assay based on TFR3/4 primers. Diagnostic real-time PCRs and DNA sequencing of the internal transcribed region confirmed presence ofT. foetusin 35 out of 36 samples. Multilocus genotyping using cysteine proteases (CP1, CP2, CP4, CP5, CP6, CP7, CP8, CP9) and malate dehydrogenase (MDH1) gene sequences demonstrate that theT. foetusin Namibia are genetically distinct from those characterized elsewhere. We report the discovery of a novel genotype ofT. foetusin Namibian cattle, distinct from otherT. foetusgenotypes in Europe, South and North America and Australia. We suggest recognition of a ‘Southern African’ genotype ofT. foetus. Identification of the new genotype ofT. foetusdemonstrates the need for wider global sampling to fully understand the diversity and origin ofT. foetuscausing disease in cattle or cats.
Valuable Asymmetrical Friendships
Authors: Mooney T. Brian , Williams John N. 
Published: September 2016

AbstractAristotle distinguishes friendships of pleasure or utility from more valuable ‘character friendships’ in which the friend cares for the otherquaperson for the other's own sake. Aristotle and some neo-Aristotelians require such friends to be fairly strictly symmetrical in their separateness of identity from each other, in the degree to which they identify with each other, and in the degree to which they are virtuous. We argue that there is a neglected form of valuable friendship – neither of pleasure nor utility – that allows significant asymmetries. We know of no sustained discussion of such ‘asymmetrical’ friendships in the literature.
Prevalence of serum anti-neuronal autoantibodies in patients admitted to acute psychiatric care
Authors: Schou M. , Sæther S. G. , Borowski K. , Teegen B. , Kondziella D. , Stoecker W. , Vaaler A. , Reitan S. K. 
Published: September 2016

BackgroundAutoimmune encephalitis associated with anti-neuronal antibodies may be challenging to distinguish from primary psychiatric disorders. The significance of anti-neuronal antibodies in psychiatric patients without clear evidence of autoimmune encephalitis is unknown. We investigated the serum prevalence of six anti-neuronal autoantibodies in a cohort of unselected patients admitted to acute psychiatric care.MethodSerum was drawn from 925 patients admitted to acute psychiatric in-patient care. Psychiatric diagnoses were set according to International Classification of Diseases (ICD)-10 criteria. Antibody analysis was performed with an indirect immunofluorescence test for N-methyl d-aspartate receptor (NMDAR) antibodies and five other anti-neuronal autoantibodies of the immunoglobulin (Ig) classes IgA, IgG and IgM isotype.ResultsAnti-neuronal autoantibodies were found in 11.6% of patients: NMDAR antibodies in 7.6%, contactin-associated protein-like 2 (CASPR2) antibodies in 2.5%, glutamic acid decarboxylase-65 (GAD65) antibodies in 1.9%, and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antibodies in 0.1%. Leucine-rich glioma-inactivated protein-1 (LGI1) and γ-aminobutyric acid B (GABAB) receptor antibodies were not detected. NMDAR antibodies of class IgG were present in five patients only (0.5%). NMDAR antibodies of all Ig classes were equally prevalent in patients with and without psychosis. There were no significant differences in antibody prevalence in the different diagnostic categories, except for a higher odds ratio of being NMDAR antibody positive for patients without a specific psychiatric diagnosis.ConclusionsNMDAR IgG autoantibodies, which are known to be strongly associated with anti-NMDAR encephalitis, were rarely found. CASPR2 and GAD65 antibodies were more frequently encountered in the present study than previously reported. Further research on the clinical significance of anti-neuronal autoantibodies in patients with acute psychiatric symptoms is needed.
Recent trends in primary-care antidepressant prescribing to children and young people: an e-cohort study
Authors: John A. , Marchant A. L. , Fone D. L. , McGregor J. I. , Dennis M. S. , Tan J. O. A. , Lloyd K. 
Published: September 2016

BackgroundConcerns relating to increased use of psychotropic medication contrast with those of under-treatment and under-recognition of common mental disorders in children and young people (CYP) across developed countries. Little is known about the indications recorded for antidepressant prescribing in primary care in CYP.MethodThis was an electronic cohort study of routinely collected primary-care data from a population of 1.9 million, Wales, UK. Poisson regression was undertaken to model adjusted counts of recorded depression symptoms, diagnoses and antidepressant prescriptions. Associated indications were explored.Results3 58 383 registered patients aged 6–18 years between 1 January 2003 and 31 December 2013 provided a total of 19 20 338 person-years of follow-up. The adjusted incidence of antidepressant prescribing increased significantly [incidence rate ratio (IRR) for 2013 = 1.28], mainly in older adolescents. The majority of new antidepressant prescriptions were for citalopram. Recorded depression diagnoses showed a steady decline (IRR = 0.72) while depression symptoms (IRR = 2.41) increased. Just over half of new antidepressant prescriptions were associated with depression (diagnosis or symptoms). Other antidepressant prescribing, largely unlicensed, was associated with diagnoses such as anxiety and pain.ConclusionAntidepressant prescribing is increasing in CYP while recorded depression diagnoses decline. Unlicensed citalopram prescribing occurs outside current guidelines, despite its known toxicity in overdose. Unlicensed antidepressant prescribing is associated with a wide range of diagnoses, and while accepted practice, is often not supported by safety and efficacy studies. New strategies to implement current guidance for the management of depression in CYP are required.
Effect of self-focused cosh Gaussian laser beam on the excitation of electron plasma wave and particle acceleration
Authors: Gaur B. , Rawat P. , Purohit G. 
Published: September 2016

AbstractThis work presents an investigation of the self-focusing of a high-power laser beam having cosh Gaussian intensity profile in a collissionless plasma under weak relativistic-ponderomotove (RP) and only relativistic regimes and its effect on the excitation of electron plasma wave (EPW), and particle acceleration process. Nonlinear differential equations have been set up for the beam width and intensity of cosh Gaussian laser beam (CGLB) and EPW using the Wentzel-Kramers-Brillouin and paraxial-ray approximations as well as fluid equations. The numerical results are presented for different values of decentered parameter ‘b’ and intensity parameter ‘a’ of CGLB. Strong self-focusing is observed in RP regime as compared with only relativistic nonlinearity. Numerical analysis shows that these parameters play crucial role on the self-focusing of the CGLB and the excitation of EPW. It is also found that the intensity/amplitude of EPW increases withbanda. Further, nonlinear coupling between the CGLB and EPW leads to the acceleration of electrons. The intensity of EPW and energy gain by electrons is significantly affected by including the ponderomotive nonlinearity. The energy of the accelerated electrons is increased by increasing the value of ‘b’. The results are presented for typical laser and plasma parameters.
Coherency, free inverse monoids and related free algebras
Authors: GOULD VICTORIA , HARTMANN MIKLÓS 
Published: September 2016

AbstractA monoidSisright coherentif every finitely generated subact of every finitely presented rightS-act is finitely presented. This is the non-additive notion corresponding to that for a ringRstating that every finitely generated submodule of every finitely presented rightR-module is finitely presented. For monoids (and rings) right coherency is an important finitary property which determines, amongst other things, the existence of amodel companionof the class of rightS-acts (rightR-modules) and hence that the class of existentially closed rightS-acts (rightR-modules) is axiomatisable.Choo, Lam and Luft have shown that free rings are right (and left) coherent; the authors, together with Ruškuc, have shown that (free) groups, free commutative monoids and free monoids have the same properties. It is then natural to ask whether other free algebras in varieties of monoids, possibly with an augmented signature, are right coherent. We demonstrate that free inverse monoids are not.Munn described the free inverse monoid FIM(Ω) on Ω as consisting of birooted finite connected subgraphs of the Cayley graph of the free group on Ω. Sitting within FIM(Ω) we have free algebras in other varieties and quasi-varieties, in particular the free left ample monoid FLA(Ω) and the free ample monoid FAM(Ω). The former is the free algebra in the variety of unary monoids corresponding to partial maps with distinguished domain; the latter is the two-sided dual. For example, FLA(Ω) is obtained from FIM(Ω) by considering only subgraphs with vertices labelled by elements of the free monoid on Ω.The main objective of the paper is to show that FLA(Ω)isright coherent. Furthermore, by making use of the same techniques we show that FIM(Ω), FLA(Ω) and FAM(Ω) satisfy (R), (r), (L) and (l), related conditions arising from the axiomatisability of certain classes of rightS-acts and of leftS-acts.
Portugal and Angola: similarities and differences inToxoplasma gondiiseroprevalence and risk factors in pregnant women
Authors: LOBO M. L. , PATROCINIO G. , SEVIVAS T. , DE SOUSA B. , MATOS O. 
Published: September 2016

SUMMARYIn this study we determined the presence of IgM/IgG antibodies toToxoplasma gondiiin sera of 155 and 300 pregnant women from Lisbon (Portugal) and Luanda (Angola), respectively, and evaluated the potential risk factors associated with this infection. DNA detection was performed by PCR assays targetingT. gondiiregions (RE/B1). Overall, 21·9% (10·9% IgG, 10·9% IgG/IgM) of the Lisbon women and 27·3% (23·7%, IgG, 2% IgM, 1·7% IgG/IgM) of the Luanda women had antibodies toT. gondii. Single variable and binary logistic regression analyses were conducted. Based on the latter, contacts with cats (family/friends), and having more than two births were identified as risk factors forToxoplasmainfection in Lisbon women. In Luanda, the risk factors forT. gondiiinfection suggested by the single variable analysis (outdoor contact with cats and consumption of pasteurized milk/dairy products) were not confirmed by binary logistic regression. This study shows original data from Angola, and updated data from Portugal in the study of infection byT. gondiiin pregnant women, indicating that the prevalence of anti-Toxoplasmaantibodies is high enough to alert the government health authorities and implement appropriate measures to control this infection.
A geostatistical investigation of agricultural and infrastructural risk factors associated with primary verotoxigenicE. coli(VTEC) infection in the Republic of Ireland, 2008–2013
Authors: ÓHAISEADHA C. , HYNDS P. D. , FALLON U. B. , O'DWYER J. 
Published: September 2016

SUMMARYIreland reports the highest incidence of verotoxigenicEscherichia coli(VTEC) infection in Europe. This study investigated potential risk factors for confirmed sporadic and outbreak primary VTEC infections during 2008–2013. Overall, 989 VTEC infections including 521 serogroup O157 and 233 serogroup O26 were geo-referenced to 931 of 18 488 census enumeration areas. The geographical distribution of human population, livestock, unregulated groundwater sources, domestic wastewater treatment systems (DWWTS) and a deprivation index were examined relative to notification of VTEC events in 524 of 6242 rural areas. Multivariate modelling identified three spatially derived variables associated with VTEC notification: private well usage [odds ratio (OR) 6·896,P< 0·001], cattle density (OR 1·002,P< 0·001) and DWWTS density (OR 0·978,P= 0·002). Private well usage (OR 18·727,P< 0·001) and cattle density (OR 1·001,P= 0·007) were both associated with VTEC O157 infection, while DWWTS density (OR 0·987,P= 0·028) was significant within the VTEC O26 model. Findings indicate that VTEC infection in the Republic of Ireland is particularly associated with rural areas, which are associated with a ubiquity of pathogen sources (cattle) and pathways (unregulated groundwater supplies).
Epidemiological profile and genetic diversity of sapoviruses (SaVs) identified in children suffering from acute gastroenteritis in Pune, Maharashtra, Western India, 2007–2011
Authors: LASURE N. , GOPALKRISHNA V. 
Published: September 2016

SUMMARYSapoviruses (SaVs) are responsible for sporadic cases and outbreaks of acute gastroenteritis. Despite this, few studies in India have focused on the epidemiological investigation of SaV in cases of acute gastroenteritis. The aim of this study was to understand the molecular epidemiology, genetic diversity and clinical impact of SaV in diarrhoeic children from Pune, Western India. Between 2007 and 2011, a total of 985 faecal samples from diarrhoeic cases and non-diarrhoeic controls were collected and examined for the presence of SaV by nested RT–PCR. SaV was detected in 2·7% (21/778) of the cases and 1·9% (4/207) of the controls. We observed that the majority of SaV mono-infections caused severe gastroenteritis (67%) with clinical manifestations of diarrhoea (100%), vomiting (73%) and dehydration (80%). All known human SaV genogroups were detected in the study. At least eight genotypes were identified from cases and controls. Genogroups GIV and GV, along with genotypes GI.5, GII.4 and GII.6, were discovered for the first time in India. Two GII.4 study strains were found to be 98·5–99% identical, having a novel intra-genogroup recombinant (GII.1/GII.4) recently reported from the Philippines, suggesting probable evidence of recombination. The circulation pattern of SaV genotypes varied during the study period, with GII.1 being predominant in 2007 and 2009, GIV.1 in 2008, and GV.1 in 2011.