bluuebunny/crossref_metadata_2025_split huggingface dataset:
The correlation between gain of chromosome 8q and survival in patients with clear and papillary renal cell carcinoma
Authors: Mehrazin Reza , Dulaimi Essel , Uzzo Robert G. , Devarjan Karthik , Pei Jianming , Smaldone Marc C. , Kutikov Alexander , Testa Joseph R. , Al-Saleem Tahseen 
Published: October 2017

Background: The proto-oncogene c-MYC, located on chromosome 8q, can be upregulated through gain of 8q, causing alteration in biology of renal cell carcinoma (RCC). The aim of this study was to evaluate the prevalence of c-MYC through chromosome 8q gain and to correlate findings with cancer-specific mortality (CSM), and overall survival (OS). Methods: Cytogenetic analysis by conventional or Chromosomal Genomic Microarray Analysis (CMA) was performed on 414 renal tumors. Nonclear and nonpapillary RCC were excluded. Impact of gain in chromosome 8q status on CSM, OS, and its correlation with clinicopathological variables were evaluated. CSM and OS were assessed using log-rank test and the Cox proportional hazards model. Results: A total of 297 RCC tumors with cytogenetic analysis were included. Gain of 8q was detected in 18 (6.1%) tumors (9 clear cell and 9 papillary RCC), using conventional method ( n = 11) or CMA ( n = 7). Gain of 8q was associated with higher T stage ( p < 0.001), grade ( p < 0.001), nodal involvement ( p = 0.005), and distant metastasis ( p < 0.001). No association between gain of 8q and age ( p = 0.23), sex ( p = 0.46), and Charlson comorbidity index (CCI, p = 0.59) were seen. Gain of 8q was associated with an 8.38-fold [95% confidence interval (CI), 3.83–18.34, p < 0.001] and 3.31-fold (95% CI, 1.56–7.04, p = 0.001) increase in CSM and decrease in OS, respectively, at a median follow up of 56 months. Conclusion: Chromosome 8q harbors the proto-oncogene c-MYC, which can be upregulated by gain of 8q. Our findings suggest that gain of 8q, can predict aggressive tumor phenotype and inferior survival in RCC.
SLAMF7-CAR T cells eliminate myeloma and confer selective fratricide of SLAMF7+ normal lymphocytes
Authors: Gogishvili Tea , Danhof Sophia , Prommersberger Sabrina , Rydzek Julian , Schreder Martin , Brede Christian , Einsele Hermann , Hudecek Michael 
Published: October 2017

Key Points
SLAMF7-CAR T cells are effective against proteasome inhibitor/immunomodulatory drug–refractory myeloma. SLAMF7-CAR T cells confer fratricide of SLAMF7+/high normal lymphocytes.
Preserving the independence of people living with multiple sclerosis towards the end of life
Authors: Costello John 
Published: October 2017

Background: Multiple sclerosis (MS) is the most common neurological disease affecting the central nervous system. It has several subtypes. The condition's pathophysiology can involve many body systems, but there are common symptoms. Treatment is both conventional and unconventional, including the controversial use of medicinal cannabis to control pain. Diagnosis can be difficult, as a case study illustrates. Support services are available to patients and carers in the form of MS support groups. People with MS contribute towards their own sense of wellbeing in a number of ways, and a key feature of survivorship with MS is the development of a positive attitude and a sense of hope. Palliative care involves facilitating a good quality of life as the condition progresses into the advanced stages. Invariably, people with MS wish to spend their last days at home among their loved ones. Numerous issues arise around end-of-life care and the role of the nurse in providing palliative care, which includes support needed by lay caregivers, who are often family members. This article will appear as a chapter in Adult Palliative Care for Nursing, Health and Social Care, edited by John Costello, to be published by SAGE Publications Ltd in 2018. It is reproduced with kind permission of SAGE Publications Ltd.
Correlação entre dados de perfilagem geofísica e potencial de bombeamento de poços em litotipos da Formação Cauê no sudoeste do Quadrilátero Ferrífero, MG
Authors: Dantas Júlia Cotta Maciel , Mesquita Daniele Costa de , Paula Rodrigo Sergio de , Guerra Kênia Janete 
Published: October 2017

O presente artigo consiste em uma integração litológica-hidrológica com base em dados de perfilagem geofísica realizada em poços tubulares profundos. Seu principal objetivo é a comparação e definição dos litotipos mais favoráveis para prospecção de água subterrânea na área de estudo. A metodologia envolveu a análise dos perfis geofísicos e sua interpretação em conjunto com a litologia e valores de vazão específica de cada poço. No caso dos litotipos do Aquífero Cauê, as litologias brandas tendem a ter mais água que litologias compactas e, de modo geral, hematitas são mais ricas em água do que itabiritos, ainda que, a quantidade de água nos diferentes tipos de itabirito tenha uma boa variação.
Dabigatran-Induced Spontaneous Hemopericardium and Cardiac Tamponade
Authors: Jelani Qurat-ul-ain , Gordon Ram , Schussheim Adam 
Published: October 2017

Four novel oral anticoagulant agents are currently available for the prevention and treatment of thromboembolic events in patients with nonvalvular atrial fibrillation. We present an unusual case of spontaneous hemopericardium and tamponade in an 87-year-old man with atrial fibrillation who was taking one such agent, dabigatran, as thromboprophylaxis.
Our case highlights both a rare bleeding complication of dabigatran use and the effectiveness of idarucizumab, its newly approved reversal agent. Especially in elderly patients, we recommend that clinicians evaluate risk factors, closely monitor patient status, and consider alternatives to the newer anticoagulants when the risk of bleeding is high.
Evaluation of violence against women in the context of analytic psychotherapy<p>Kadına yönelik şiddetin analitik psikoterapi bağlamında değerlendirilmesi
Authors: Bozdağ Faruk , Voltan Acar Nilüfer 
Published: October 2017

In this study, it was aimed to evaluate violence against women, one of the common problems of the society, especially in the context of analytical psychotherapy, based on some recent events in the media. For this purpose, two cases involving violence against women were discussed with the basic approach of analytical psychotherapy. In the study, the emotions, thoughts and behaviors of violent men were tried to be explained based on the concepts of conscious, unconscious, complex and archetypes of analytical psychotherapy. As a result, in this study, some clues about the points that psychological counselors should take into consideration in the psychological treatment of men who resort to violence against women.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetBu çalışmada toplumun yaygın sorunlarından biri olan kadına yönelik şiddetin özellikle son zamanlarda medyada yer alan bazı olaylar temel alınarak analitik psikoterapi bağlamında değerlendirilmesi amaçlanmıştır. Bu amaçla kadına yönelik şiddeti içeren iki olay, analitik psikoterapinin temel yaklaşımıyla ele alınmıştır. Çalışmada şiddet uygulayan erkeklerin duygu, düşünce ve davranışları analitik psikoterapinin bilinç, bilinçdışı, kompleks ve arketip kavramları esas alınarak açıklanmaya çalışılmıştır. Sonuç olarak bu çalışmada kadına yönelik şiddet uygulayan erkeklerin psikolojik tedavilerinde psikolojik danışmanların göz önünde bulundurmaları gereken noktalara ilişkin bir takım ipuçları ortaya çıkmıştır.
EDUCAÇÃO A DISTÂNCIA CENTRADA NA APRENDIZAGEM: REFLEXÕES SOBRE ENSINO, PESQUISA E EXTENSÃO
Authors: Rodriguez Lilian Lorenzato , Júnior Álvaro Veiga , Cardoso Adriana Lessa , Araújo Pâmela Renata Machado 
Published: October 2017

O trabalho objetiva propor reflexões a respeito da possibilidade de integração entre ensino, pesquisa e extensão tendo por base suas experiências docentes de professoras formadoras no Curso de Licenciatura em Pedagogia a Distância, CLPD/UFPEL. O quadro teórico-metodológico se constitui na perspectiva da Pedagogia Popular e Problematizadora de Paulo Freire e na compreensão das atuais políticas públicas para a educação. Este ensaio se pauta nas metodologias qualitativas em educação, especialmente na perspectiva de práxis pedagógica e de ciclos gnosiológicos para propor os entendimentos acordados, não pretendendo certificar verdades, mas sim motivar diálogos. Tais reflexões procuram reunir o posicionamento das professoras formadoras em seu movimento dialético-dialógico entre prática, teoria e prática e, ação, reflexão e ação; ao vivenciarem os ciclos gnosiológicos. Entendemos que este curso é um exemplo de interação entre diferentes dimensões sociais e culturais, pois a concepção utilizada de Ead, centrada na aprendizagem construtiva e cooperativa, realimentada pela práxis pedagógica crítica e emancipadora, nos permitiram vivenciar diferentes intensidades e frequências de articulação dos três pilares da ciência Brasileira. As noções integradoras, aquelas que favorecem o entendimento de totalidades interdependentes e dinâmicas, permitem o diálogo crítico entre dimensões globais e locais, dimensões ambientais, econômicas e sociais, desta maneira, favorecem por sua vez uma percepção e consciência que superem a alienação, fragmentação, efemeridade e o individualismo. Os sujeitos da educação ao conhecerem a realidade concreta cultural e historicamente podem superar a sua condição ingênua e assim transformarem-se e transformá-la.
Exploration of the impact of nearby sources on urban atmospheric inversions using large eddy simulation
Authors: Gaudet Brian J. , Lauvaux Thomas , Deng Aijun , Davis Kenneth J. 
Published: October 2017

The Indianapolis Flux Experiment (INFLUX) aims to quantify and improve the effectiveness of inferring greenhouse gas (GHG) source strengths from downstream concentration measurements in urban environments. Mesoscale models such as the Weather Research and Forecasting (WRF) model can provide realistic depictions of planetary boundary layer (PBL) structure and flow fields at horizontal grid lengths (Δx) down to a few km. Nevertheless, a number of potential sources of error exist in the use of mesoscale models for urban inversions, including accurate representation of the dispersion of GHGs by turbulence close to a point source.
Here we evaluate the predictive skill of a 1-km chemistry-adapted WRF (WRF-Chem) simulation of daytime CO2 transport from an Indianapolis power plant for a single INFLUX case (28 September 2013). We compare the simulated plume release on domains at different resolutions, as well as on a domain run in large eddy simulation (LES) mode, enabling us to study the impact of both spatial resolution and parameterization of PBL turbulence on the transport of CO2. Sensitivity tests demonstrate that much of the difference between 1-km mesoscale and 111-m LES plumes, including substantially lower maximum concentrations in the mesoscale simulation, is due to the different horizontal resolutions. However, resolution is insufficient to account for the slower rate of ascent of the LES plume with downwind distance, which results in much higher surface concentrations for the LES plume in the near-field but a near absence of tracer aloft. Physics sensitivity experiments and theoretical analytical models demonstrate that this effect is an inherent problem with the parameterization of turbulent transport in the mesoscale PBL scheme. A simple transformation is proposed that may be applied to mesoscale model concentration footprints to correct for their near-field biases. Implications for longer-term source inversion are discussed.
Los párrocos y las redes de sociabilidad parroquial en el mundo rural de la Cataluña moderna: historiografía e historia
Authors: Puigvert i Solà Joaquim M. 
Published: October 2017

Dos son los principales objetivos que nos proponemos en este artículo: en primer lugar, reflexionar sobre la evolución de la parroquia rural como objeto de estudio historiográfico en Cataluña a lo largo del siglo XX contextualizando debidamente esta evolución dentro del marco español y europeo; y, en segundo lugar, dar una visión sintética y global, desde la perspectiva de la historia social, de los distintos roles jugados, de manera especial a lo largo del siglo XVIII, por la densa red parroquial exitente en las distintas diócesis catalanas, los párrocos que gobernaron las parroquias y las principales estructuras parroquiales que vehicularon la sociabilidad de los fieles, de manera especial las fábricas parroquiales y las cofradías.
Mercury poisoning in a fisherman working on a pelagic fishing vessel due to excessive tuna consumption
Authors: Ahn Ji-Sung , Kang Kyung Wook , Kang Won-Yang , Lim Hyeong-Min , Cho Seunghyeon , Moon Jai-Dong , Park Won-Ju 
Published: October 2017

Abstract

Objective
To report the case of a fisherman who developed chronic mercury poisoning due to excessive consumption of tuna while working on a pelagic fishing vessel.

Case report
A 48-year-old male deep-sea fisherman developed paresthesia and pain in both legs while working at sea. He continued working for over 4 months on a pelagic fishing vessel but was eventually unable to function normally as his condition deteriorated. Upon arrival on land, he received specialist treatment, including imaging studies, for 2 months; however, the cause of the symptoms was not identified. An examination of his occupational history revealed that he had worked as a crew member on a pelagic fishing vessel catching tuna for the last 2 years and consumed tuna for two or more meals per day, every day. Two months after discontinuation of tuna consumption, he was tested for mercury. The result showed an elevated blood mercury level (BML) of 21.79μg/l. Based on the half-life of mercury, the BML was evaluated as 38.70-53.20 μg/l when he was on board. Four months after discontinuing tuna consumption, his BML decreased to 14.18 μg/l, and the symptoms were almost ameliorated. The person responsible for preparing meals on a pelagic fishing ship should be aware that fish may contain high levels of heavy metals and should prepare meals for crew members according to the recommended levels. Crew members should also be aware that fish and shellfish may contain mercury, and hence, they should consume only an appropriate amount.
Seguimento farmacoterapêutico de pacientes em tratamento com talidomida em um centro especializado em hanseníase
Authors: Lucas Holanda de Vasconcelos Rafhael , Pereira dos Santos Webysten Ronny , Lopes Sousa Allyson Martins , Leal Laynne Hellen de Carvalho , Rezende Júnior Luís Mario , Reis Jociane Alves da Silva , Samoa Dany Gabriel , Ferreira Pablo Ricardo Barbosa , De Araújo Éverton José Ferreira 
Published: October 2017

***Pharmacotherapeutic follow-up of patients treated with thalidomide at a specialized leprosy center*** AIMS: To evaluate the pharmacotherapeutic follow-up of patients with type 2 leprosy reaction in treatment with thalidomide in a philanthropic center of specialized care at Teresina. METHODS: The study was conducted at the Centro Maria Imaculada, for rehabilitation of patients with leprosy, in the city of Teresina, Piauí, Brazil. Patients of both sexes attended between september and november 2016 were included in the study. Pharmacotherapeutic follow-up was based on the Dáder Method, in the electronic base Drugdex System - Thomson Micromedex® - Interactions for analysis of drug interactions; in the classification of adverse drug reactions of Rawlins and Thompson; and the Morisky-Green test to evaluate the level of therapeutic adherence. RESULTS: Eleven patients were followed, of whom eight were male. Three drug interactions were identified, two of which were classified as moderate risk and one in lower risk. There were 23 negative results associated with medicines, mainly quantitative insecurity and untreated health problems. In addition, 22 drug-related problems were identified, with adverse drug reactions being the most frequent occurrence. All adverse drug reactions were classified as type A or predictable. Regarding adhesion, six patients among nine who responded to the Morisky-Green test obtained a high degree of adhesion. Health education corresponded to the preponderant pharmaceutical intervention, being applied to all patients. CONCLUSIONS: Relevant drug interactions, negative results associated with medicines, and drug-related problems were identified. Degree of adherence to thalidomide treatment was considered high. Pharmaceutical interventions were necessary, mainly focused on health education actions, which ratifies the need for constant monitoring of this group of patients.
Telekardiológia: A telemedicina feladatai és kötelességei
Authors: Borbás János , Forczek Erzsébet , Sepp Róbert , Bari Ferenc 
Published: October 2017

Abstract: Telemedicine is a young science that integrates innovations of information-technology and telecommunications into medical science. A successful telemedicine procedure should guarantee reduced workload of the healthcare system with well secured and cost-effective processes. Our goal was to collect the development phases of telemedicine projects through existing telecardiology solutions. Subsequent to reviewing international publications we analyzed the past and present situation of blood pressure monitoring, remote diagnostics of electrocardiography, implantable cardioverter defibrillator monitoring and pocket ultrasound devices. In case of new solutions (a) several internationally accepted, confidently reproducible “good practices” are needed for creating (b) guidelines and recommendations of international medical associations. They have to ensure (c) cost-effective work, with well-designed sustainability and (d) patient confidentiality. Improving (e) education for professionals and patients is essential. We recommend to telemedicine developers to use our standards in order to introduce their products more effectively into clinical practice. It is encouraging that current possibilities of telecardiology partly or fully meet the aforementioned criteria. Further development of the topic can contribute to financial sustainability of our healthcare and might be able to resolve limitations of human resources. Orv Hetil. 2017; 158(44): 1741–1746.
Intergrated Water Management in the Wood Manufacturing Industry
Authors: Hogland William , Marques Marcia 
Published: October 2017

Industrial wastewater management is still neglected in a dominating part of the companies in Sweden and it is not considered as a threat to health of man and environment. The Environmental Science &Engineering Research Group (ESERG) at LNU has under financial support of KK-foundation and large/medium-size companies in Southern Sweden been studied. Even though the problem has been studied for half a century there is knowledge missing and the stormwater is still a growing problem. Every time rain falls, it washes off oils, microorganisms, litter, sediments, fertilizers, and foreign chemicals from streets, parking lots, lawns, dumpster pads, metal roofs as well from landfill, industrial and harbour sites. Industrial facilities with large impervious surfaces for different types of handling of materials are generating stormwater effluents of different qualities which vary during different time periods and same stands for process water generated of a variety of volumes and often of high pollutant concentrations. In some catchment areas, industrial and small business activities can release a significant portion of some pollutants that ends up directly into receiving waters but also at the municipal wastewater treatment plant. Small businesses and enterprises do not pay attention to routine operations and neither have they had the economic resources to implement preventive measures, treatment facilities or to employ expertise on their particular environmental issues. The project “Development of an Integrated Approach for Industrial Wastewater and Stormwater Management in the Wood Industry Sector” has generated new knowledge about industrial waste water treatment that will be presented at the Linnaeus Ecotech 10 international conference.
The Influence of Training on Preferences
Authors: Alriksson Stina 
Published: October 2017

Any organisation or company that want to bring about a change in the process, procedures or internal organisation encounters the issue of training the staff. Training is commonly used to increase dedication in specific issues for example environmental issues, energy saving or enhancing the overall competence of the staff.
When working with environmental- or energy issues, the attitude of the employees is often considered one of the most important factors for the outcome. In this paper two different studies are compared. In both studies training has been included as a background factor in a conjoint analysis study.
The first study concerns preferences for new materials, in this case advanced high strength steel. The respondents were asked to rank eight alternative steel containers and the results, (preferences) were compared to any previous training the individual respondent had. The same procedure was taken in study number two where employees at a paper & pulp industry was asked to rank eight alternative processes with different environmental impacts.
Also here the respondents were asked to state any previous training and the preferences was compared to previous training.
It has not been possible to show any significant connection between preferences in a specific issue and training in the same area. However, it would be interesting to use the method to measure the effect of training on preferences before and after a specific training session.
Celebrate Birth!—Remembering the Breaks: A Water Birth
Authors: Moen Katherine C. 
Published: October 2017

ABSTRACTIn this birth story, Katherine shares that she wanted an unmedicated birth. She planned a hospital birth with a midwife. During her pregnancy, she hired a doula and she and her husband, Corey, attended both natural childbirth classes and a natural comfort measures class. Katherine had an intense labor but was able to relax between contractions, and with the support of her husband and doula, she managed to cope with increasingly difficult contractions. Her commitment and hard work during labor, and the emotional and physical support she received, helped her achieve the unmedicated birth she wanted. Katherine and her husband welcomed their daughter, Clara Mae, into the world after 10.5 hours of labor.
Building a Maternal and Newborn Care Training Programme for Health-Care Professionals in Guinea-Bissau
Authors: Reynolds Ana , Zaky Ahmed , Moreira-Barros Joana , Bernardes João 
Published: October 2017

Introduction: The Integrated Programme of Maternal and Child Health aims to reduce maternal and child mortality in Guinea-Bissau. The purpose of this article is to share our experience in building a training programme on maternal and newborn care for health-care professionals in Guinea-Bissau.Material and Methods: Regional directors of the four target areas chose a group of staff who provide prenatal and childbirth care to attend the course (12 to 15 trainees per region). In each region, 15 highly interactive and practical sessions were scheduled over eight weeks. The trainees’ summative and reactive assessment was obtained using a multiple choice questionnaire (final test) and an anonymous survey, respectively.Results: Attendees included 25 nurses, 17 midwives and 14 doctors. About two thirds had five years’ practice or less. Test median scores were higher among trainees with two to nine years of practice (54.4% to 60.9%), as compared to those with a year or less (47.8%) or 10 or more years (45.7%). Pedagogical variables were rated as ‘good’ or ‘very good’ by 91% to 95% of the attendees.Discussion: Use of an interactive and practical pedagogical methodology produced positive results and was crucial to tailoring the training to local needs. However, adapting the syllabus according to professional categories and experiences should be considered.Conclusion: Our results warrant further development and evaluation of training programmes on maternal and neonatal care in Guinea-Bissau.