bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surface‐bound collagen 4 is significantly more stable than collagen 1
Authors: Stynes Gil D. , Kiroff George K. , Page Richard S. , Morrison Wayne A. , Kirkland Mark A. 
Published: January 2017

AbstractCollagen 1 (C1) is commonly used to improve biological responses to implant surfaces. Here, the stability of C1 was compared with collagen 4 (C4) on a mixed macrodiol polyurethane, both adsorbed and covalently bound via acetaldehyde glow discharge polymerization and reductive amination. Substrate specimens were incubated in solutions of C1 and C4. The strength of conjugation was tested by incubation in 8Murea followed by enzyme linked immunosorbent assays to measure residual C1 and C4. The basal lamina protein, laminin‐332 (L332) was superimposed via adsorption on C4‐treated specimens. Keratinocytes were grown on untreated, C1‐treated, C4‐treated, and C4 + L332‐treated specimens, followed by measurement of cell area, proliferation, and focal adhesion density. Adsorbed C4 was shown to be significantly more stable than C1 and covalent conjugation conferred even greater stability, with no degradation of C4 over twenty days in 8Murea. Cell growth was similar for C1 and C4, with no additional benefit conferred by superimposition of L332. The greater resistance of C4 to degradation may be consequent to cysteine residues and disulphide bonds in its non‐collagenous domains. The use of C4 on implants, rather than C1, may improve their long‐term stability in tissues. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1364–1373, 2017.
Bioactive tricalcium silicate/alginate composite bone cements with enhanced physicochemical properties
Authors: Xu Chen , Wang Xiaoya , Zhou Jie , Huan Zhiguang , Chang Jiang 
Published: January 2017

AbstractPrevious studies have shown that tricalcium silicate bone cements possess good bioactivity and appropriate degradation rate. However, they also showed some weaknesses such as poor washout resistance, formability and injectability, which have seriously hindered their clinical applications. The purpose of this study was to develop a new type of bone cements—tricalcium silicate/sodium alginate (C3S/SA) composites by utilizing the interaction of Ca ions with SA molecules, in which an interpenetrating double‐network of calcium hydrate silicate (CSH) and alginate hydrogel was formed to enhance the washout resistance, formability, injectability and compressive strength of C3S. The results confirmed that the washout resistance, formability and injectability of C3S could indeed be greatly enhanced by the introduction of SA. In addition, the compressive strength of the C3S/SA composite cement with an optimum composition could reach 54 MPa, which was significantly higher than that of C3S (i.e., 35.3 MPa). Moreover, the C3S/SA composite cements retained the bioactivity of C3S, such as the activity to induce apatite formation in simulated body fluid and to promote cell proliferation. All these results indicate that the C3S/SA composite cements hold great promise as a new type of bone repair materials for further in vitro and in vivo studies. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 237–244, 2018.
Optimized performance of the integrated hepatic cell‐loaded cryogel‐based bioreactor with intermittent perfusion of acute liver failure plasma
Authors: Damania Apeksha , Kumar Anupam , Sarin Shiv K. , Kumar Ashok 
Published: January 2017

AbstractAcute liver failure (ALF) plasma has cytotoxic effects on the cell‐loaded bioreactor in bioartificial liver support systems due to the presence of innumerable hepatotoxic compounds that adversely affect the morphology and functionality of the cells. We have designed a hybrid bioreactor that integrates a hepatic cell‐loaded cryogel disc and an activated carbon cloth in one compact unit, with potential application as a bioartificial liver support. In this article, we assess the performance of this integrated hybrid cryogel‐based bioreactor in a perfusion‐based culture system and analyze its functionality and longevity in the presence of intermittent exposure to ALF plasma. The bioreactor maintained functionality in terms of glucose consumption and albumin synthesis for up to 40 days under perfusion. Additionally, intermittent perfusion of plasma from rodent models of ALF resulted in a decrease in viability and functionality only after the second spike of plasma, with the bioreactor maintaining its functionality even after the first spike. Similar results were obtained with patient plasma indicating the potential to reuse the bioreactor for multiple sessions of liver dialysis. Collectively, these results suggest the potential of the integrated cryogel‐based bioreactor to be used at most twice before being disposed of. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 259–269, 2018.
Improved workflow for quantifying left ventricular function via cardiorespiratory‐resolved analysis of free‐breathing MR real‐time cines
Authors: Wu Yin , Wan Qian , Zhao Jing , Liu Xin , Zheng Hairong , Chung Yiu‐Cho , Chen Yucheng 
Published: January 2017

PurposeTo evaluate the feasibility of a proposed cardiorespiratory‐resolved analysis in left ventricular (LV) function quantification from real‐time cines in a cohort of cardiac patients.Materials and MethodsElectrocardiograph (ECG)‐free free‐breathing real‐time cine imaging based on the balanced steady‐state free precession technique was performed on short‐axis slices of 20 cardiac patients at 3T. K‐means cluster segmentation was used to delineate the endocardial contours, from which the LV centroid and cavity area were determined. Respiratory and cardiac signals were respectively resolved from the filtered LV centroid displacement and time‐varied LV cavity area to identify end‐expiratory end‐diastolic (ED) and end‐systolic (ES) images. The obtained LV cavity areas and derived volumetric function indices, including ED volume (EDV), ES volume (ESV), stroke volume (SV), and ejection fraction (EF), were compared with those measured from manual analysis using two‐tailed paired Student's t‐tests, linear regression analyses, and Bland–Altman plots. Interobserver variability was calculated.ResultsThe LV cavity area was strongly correlated between the proposed and conventional manual methods (r > 0.87) for three representative slices at the base, middle ventricle, and apex. The average differences between the two methods were 0.66 ± 3.22 mL for EDV, –0.02 ± 2.68 mL for ESV, 0.67 ± 3.73 mL for SV, and 0.17 ± 2.30% for EF. All paired measures exhibited strong correlations (r > 0.96) without significant differences (P = 0.38–0.98). Acceptable interobserver variability (0.19–3.55%) and strong correlations (r > 0.96) were shown for all measures between the two observers.ConclusionThe proposed method is feasible for efficient measurement of LV function from real‐time cines.Level of Evidence: 2Technical Efficacy: Stage 1J. MAGN. RESON. IMAGING 2017;46:905–914
Advanced glycation end products stimulate gene expression of fibroblast growth factor 23
Authors: Bär Ludmilla , Wächter Kristin , Wege Nicole , Navarrete Santos Alexander , Simm Andreas , Föller Michael 
Published: January 2017

ScopeOsteoblasts produce fibroblast growth factor 23 (FGF23), a hormone inhibiting renal phosphate reabsorption and the formation of biologically active vitamin D, calcitriol. FGF23‐deficient mice age rapidly and develop age‐associated diseases at least in part due to massive calcification. Elevated FGF23 serum levels are detected in patients suffering from acute and chronic renal, cardiovascular, inflammatory, and metabolic diseases. Advanced glycation end products (AGEs) are sugar‐modified proteins, nucleic acid, and lipids which contribute to these disorders. Here, we studied the significance of AGEs for the generation of FGF23.Methods and resultsAs AGE sources, bread crust extract (BCE) and ribose‐modified bovine serum albumin (r‐BSA) were used. UMR106 osteoblast‐like cells were exposed to BCE and r‐BSA, and Fgf23 transcripts were determined by qRT‐PCR. UMR106 cells express the receptor for AGEs, RAGE. BCE and r‐BSA were powerful stimulators of Fgf23 transcription. NFκB inhibitor wogonin and store‐operated calcium entry (SOCE) antagonist 2‐APB attenuated the r‐BSA and BCE effects on FGF23 synthesis.ConclusionSources of AGEs induce the transcription of Fgf23 in UMR cells. At least in part, the effect is mediated through up‐regulation of NFκB and subsequent SOCE. AGE‐induced FGF23 production may contribute to increased FGF23 serum levels observed in chronic disease.
An observational study of Australian private practice physiotherapy consultations to explore the prescription of self‐management strategies
Authors: Peek Kerry , Carey Mariko , Mackenzie Lisa , Sanson‐Fisher Robert 
Published: February 2017

AbstractObjectiveThe aim of the study was to explore the types of self‐management strategies prescribed; the number of strategies and the overall length of time allocated to self‐management prescription, by consultation type and by injury location, in physiotherapy consultations.MethodsA cross‐sectional, observational study of 113 physiotherapist–patient consultations was undertaken. Regression analyses were used to determine whether consultation type and injury location were associated with the number of strategies prescribed and the length/fraction of time spent on self‐management.ResultsA total of 108 patients (96%) were prescribed at least one self‐management strategy – commonly exercise and advice. The mean length of time spent on self‐management was 5.80 min. Common injury locations were the neck (n = 40) and lower back (n = 39). No statistically significant associations were observed between consultation type or injury location for either outcome (number of strategies and the length/fraction of time allocated to self‐management prescription).ConclusionPhysiotherapists regularly spend time prescribing self‐management strategies such as exercise, advice, and the use of heat or ice to patients receiving treatment linked to a range of injury locations. This suggests that self‐management is considered to be an important adjunct to in‐clinic physiotherapy. The practice implications of this are that clinicians should reflect on how self‐management strategies can be used to maximize patient outcomes, and whether the allocation of consultation time to self‐management is likely to optimize patient adherence to each strategy.
Synthesis of allyl end‐block functionalized poly(ε‐caprolactone)s and their facile post‐functionalization via thiol–ene reaction
Authors: Truong Thuy Thu , Thai Son Hong , Nguyen Ha Tran , Vuong Vinh‐Dat , Nguyen Le‐Thu T. 
Published: January 2017

ABSTRACTA simple and facile strategy for the functionalization of commercial poly(ε‐caprolactone) diols (PCLs) with pendant functionalities at the polymer chain termini is described. Well‐defined allyl‐functionalized PCLs with varying numbers of allyl end‐block side‐groups were synthesized by cationic ring‐opening polymerization of allyl glycidyl ether using PCL diols as macroinitiators. Further functionalization of the allyl‐functionalized PCLs was realized via the UV‐initiated radical addition of a furan‐functionalized thiol to the pendant allyl functional groups, showing the suitability for post‐modification of the PCL materials. Changes in polymer structure as a result of varying the number of pendant functional units at the PCL chain termini were demonstrated. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 928–939
Nonmonotonic swelling of agarose‐carbopol hybrid hydrogel: Experimental and theoretical analysis
Authors: Hamzavi Nader , Dewavrin Jean‐Yves , Drozdov Aleksey D. , Birgersson Erik 
Published: January 2017

ABSTRACTA hybrid gel is synthesized by physical mixing of agarose and carbopol and an interpenetrating network of Agarose‐Carbopol (AC) hybrid gel is observed by atomic force microscopy. This hybrid gel exhibits pH‐responsiveness and mechanical stability as well as tunable swelling. These hydrogels depict a nonmonotonic swelling behavior as a function of pH. In particular, the equilibrium degree of swelling increases with pH of bath solution until its maximum value around pH =
, followed by a decrease at higher pH values. The degree of swelling is increased by the concentration of carbopol when the concentration of agarose is low [
], or decreased by the concentration of agarose when
is high [
]. A physics‐based model is also adapted to characterize the swelling‐shrinking behavior of different compositions of AC gels. This swelling‐shrinking behavior of AC hydrogels will have potential applications in smart hydrogel‐based devices. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2017, 55, 444–454
Liquid crystal elastomer actuators: Synthesis, alignment, and applications
Authors: Kularatne Ruvini S. , Kim Hyun , Boothby Jennifer M. , Ware Taylor H. 
Published: January 2017

ABSTRACTLiquid crystal elastomers (LCEs) are a unique class of materials which combine rubber elasticity with the orientational order of liquid crystals. This combination can lead to materials with unique properties such as thermal actuation, anisotropic swelling, and soft elasticity. As such, LCEs are a promising class of materials for applications requiring stimulus response. These unique features and the recent developments of the LCE chemistry and processing will be discussed in this review. First, we emphasize several different synthetic pathways in conjunction with the alignment techniques utilized to obtain monodomain LCEs. We then identify the synthesis and alignment techniques used to synthesis LCE‐based composites. Finally, we discuss how these materials are used as actuators and sensors. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys.2017,55, 395–411
In situ observations of wintertime low‐altitude clouds over the Southern Ocean
Authors: Ahn Eunmi , Huang Yi , Chubb Thomas H. , Baumgardner Darrel , Isaac Peter , de Hoog Mark , Siems Steven T. , Manton Michael J. 
Published: January 2017

Cloud droplet concentration (Nd), effective radius (reff) and liquid water content (LWC) measured by a DMT CAPS and an SEA WCM‐2000 of wintertime low‐altitude clouds over the Southern Ocean (SO) are presented for 20 flights taken over 3 years (June–October, 2013–2015). Such clouds have been reported to have the lowest Nd on record (10–40 cm−3) from the Southern Ocean Cloud Experiment (SOCEX I) field campaign in 1993. Of the total 20 357 one‐second records spent in cloud, 38.5% were found to contain ice crystals, primarily in mixed‐phase clouds (36.7%). Ice was observed at some point during 19 of the 20 missions. The droplet spectra and temperature range suggest these clouds were often ideal for the Hallett–Mossop ice multiplication process.The average Nd and reff for liquid clouds were 28 (±30) cm−3 and 12.5 (±2.9) µm, which are consistent with those from SOCEX I. Forty‐nine percent of all liquid cloud samples were observed to be drizzling with an average drizzle rate of 0.733 mm h−1. As drizzle samples were commonly in the neighbourhood of mixed‐phase or non‐drizzling clouds, it was rare to observe solid patches of drizzle of greater than 10 s. On average, drizzling clouds had lower Nd and greater reff and LWC than those of non‐drizzling clouds. Distinct observations of non‐drizzling clouds with relatively high Nd (∼89 cm−3), small reff (∼8.5 µm) and low LWC (∼0.173 g kg−1) were noted for two flights. An initial examination of the local environment and synoptic meteorology for these flights failed to identify any particular forcing that may have led to these unique microphysical properties, although these were the only observations of closed mesoscale cellular convection. This research highlights that greater variability exists in the microphysics of wintertime clouds over the SO, when a wider range of synoptic meteorology is investigated.
SETUP in secret sharing schemes using random values
Authors: Olimid Ruxandra F. 
Published: February 2017

AbstractSecret sharing schemes divide a secret among multiple participants so that only authorized subsets of parties can reconstruct it. We show that secretly embedded trapdoor with universal protection attack can be embedded in secret sharing schemes that employ enough randomness to give the attacker an overwhelming advantage to access the secret. In case of ideal schemes, a coalition of a few participants (within at least one is the attacker) can succeed the attack, while in case of non‐ideal schemes, the attacker's knowledge can be enough to reveal the secret. We exemplify the attack against Shamir's threshold scheme, which is the most well known and used secret sharing scheme. Finally, we consider some prevention techniques against the proposed attack. Copyright © 2017 John Wiley & Sons, Ltd.
Sexual Distress and Sexual Problems During Pregnancy: Associations with Sexual and Relationship Satisfaction
Authors: Vannier Sarah A. , Rosen Natalie O. 
Published: January 2017

Abstract

Introduction
Sexual problems are common during pregnancy, but the proportion of pregnant women who experience sexual distress is unknown. In non-pregnant samples, sexual distress is associated with lower sexual and relationship satisfaction.

Aim
To identify the proportion of women experiencing sexual distress during pregnancy and to compare the sexual and relationship satisfaction of women who report sexual distress during pregnancy with that of women without distress.

Methods
Two-hundred sixty-one pregnant women completed a cross-sectional online survey.

Main Outcome Measures
Women completed validated measurements of sexual functioning (Female Sexual Function Index; score &lt; 26.55 indicates a sexual problem), sexual distress (Female Sexual Distress Scale; score ≥ 15 indicates clinically significant distress), sexual satisfaction (Global Measure of Sexual Satisfaction), and relationship satisfaction (Couples Satisfaction Index).

Results
Overall, 42% of women met the clinical cutoff for sexual distress. Of sexually active women (n = 230), 26% reported concurrent sexual problems and distress and 14% reported sexual distress in the absence of sexual problems. Sexual distress and/or problems in sexual functioning were linked to lower sexual and relationship satisfaction compared with pregnant women with lower sexual distress and fewer sexual problems.

Conclusion
Sexual distress is common during pregnancy and associated with lower sexual and relationship satisfaction. Health care providers should ask pregnant women about feelings of sexual distress. Identifying pregnant women who experience sexual distress and referring them to appropriate resources could help minimize sexual and relationship problems during pregnancy.
How to play the triangle game
Authors: Crilly Tony 
Published: February 2017

We are given n sticks of lengths 1, 2, 3, …, n and three are selected at random. Which selections enable a triangle to be formed?This question can be written in the form of a game: you win if a triangle can be formed from the three numbers interpreted as side lengths, you lose if they do not.We let ℕn = {1, 2, 3, …, n}, and see there are two variants of the game:•From ℕn draw at random three numbers sequentially. At each stage do not replace the drawn number.•From ℕn a number is drawn at random and is recorded. In three stages three numbers are drawn. Replace the number at each stage.
A Genome-Wide Association Study Identifies Genetic Variants Associated with Mathematics Ability
Authors: Chen Huan , Gu Xiao-hong , Zhou Yuxi , Ge Zeng , Wang Bin , Siok Wai Ting , Wang Guoqing , Huen Michael , Jiang Yuyang , Tan Li-Hai , Sun Yimin 
Published: February 2017

AbstractMathematics ability is a complex cognitive trait with polygenic heritability. Genome-wide association study (GWAS) has been an effective approach to investigate genetic components underlying mathematic ability. Although previous studies reported several candidate genetic variants, none of them exceeded genome-wide significant threshold in general populations. Herein, we performed GWAS in Chinese elementary school students to identify potential genetic variants associated with mathematics ability. The discovery stage included 494 and 504 individuals from two independent cohorts respectively. The replication stage included another cohort of 599 individuals. In total, 28 of 81 candidate SNPs that met validation criteria were further replicated. Combined meta-analysis of three cohorts identified four SNPs (rs1012694, rs11743006, rs17778739 and rs17777541) of SPOCK1 gene showing association with mathematics ability (minimum p value 5.67 × 10−10, maximum β −2.43). The SPOCK1 gene is located on chromosome 5q31.2 and encodes a highly conserved glycoprotein testican-1 which was associated with tumor progression and prognosis as well as neurogenesis. This is the first study to report genome-wide significant association of individual SNPs with mathematics ability in general populations. Our preliminary results further supported the role of SPOCK1 during neurodevelopment. The genetic complexities underlying mathematics ability might contribute to explain the basis of human cognition and intelligence at genetic level.
Understanding cancer complexome using networks, spectral graph theory and multilayer framework
Authors: Rai Aparna , Pradhan Priodyuti , Nagraj Jyothi , Lohitesh K. , Chowdhury Rajdeep , Jalan Sarika 
Published: February 2017

AbstractCancer complexome comprises a heterogeneous and multifactorial milieu that varies in cytology, physiology, signaling mechanisms and response to therapy. The combined framework of network theory and spectral graph theory along with the multilayer analysis provides a comprehensive approach to analyze the proteomic data of seven different cancers, namely, breast, oral, ovarian, cervical, lung, colon and prostate. Our analysis demonstrates that the protein-protein interaction networks of the normal and the cancerous tissues associated with the seven cancers have overall similar structural and spectral properties. However, few of these properties implicate unsystematic changes from the normal to the disease networks depicting difference in the interactions and highlighting changes in the complexity of different cancers. Importantly, analysis of common proteins of all the cancer networks reveals few proteins namely the sensors, which not only occupy significant position in all the layers but also have direct involvement in causing cancer. The prediction and analysis of miRNAs targeting these sensor proteins hint towards the possible role of these proteins in tumorigenesis. This novel approach helps in understanding cancer at the fundamental level and provides a clue to develop promising and nascent concept of single drug therapy for multiple diseases as well as personalized medicine.