bluuebunny/crossref_metadata_2025_split huggingface dataset:
Keep Your Scanners Peeled
Authors: Hergeth Sebastian , Lorenz Lutz , Vilimek Roman , Krems Josef F. 
Published: February 2016

Objective: The feasibility of measuring drivers’ automation trust via gaze behavior during highly automated driving was assessed with eye tracking and validated with self-reported automation trust in a driving simulator study. Background: Earlier research from other domains indicates that drivers’ automation trust might be inferred from gaze behavior, such as monitoring frequency. Method: The gaze behavior and self-reported automation trust of 35 participants attending to a visually demanding non-driving-related task (NDRT) during highly automated driving was evaluated. The relationship between dispositional, situational, and learned automation trust with gaze behavior was compared. Results: Overall, there was a consistent relationship between drivers’ automation trust and gaze behavior. Participants reporting higher automation trust tended to monitor the automation less frequently. Further analyses revealed that higher automation trust was associated with lower monitoring frequency of the automation during NDRTs, and an increase in trust over the experimental session was connected with a decrease in monitoring frequency. Conclusion: We suggest that (a) the current results indicate a negative relationship between drivers’ self-reported automation trust and monitoring frequency, (b) gaze behavior provides a more direct measure of automation trust than other behavioral measures, and (c) with further refinement, drivers’ automation trust during highly automated driving might be inferred from gaze behavior. Application: Potential applications of this research include the estimation of drivers’ automation trust and reliance during highly automated driving.
Neglect and hereditary risk: Their relative contribution to schizophrenia with negative symptomatology
Authors: Gallagher Bernard J , Jones Brian J 
Published: February 2016

Background: There is evidence that genetic and environmental stressors contribute to the genesis of schizophrenia. However, the relevant impact of each factor remains unclear. We tested for an interactive effect between childhood neglect and family history of serious mental illness. Data were further analyzed for a possible connection to type of schizophrenic symptoms. Sampling/Methods: Data for the study are taken from the medical records of 641 patients with schizophrenia from a large state hospital in the northeastern United States. Clinical assessments were divided into positive and negative symptomatology through application of the Scale for the Assessment of Negative Symptoms (SANS), the Scale for the Assessment of Positive Symptoms (SAPS) and the Positive and Negative Syndrome Scale (PANSS). Detailed information about childhood neglect and family history of serious mental illness was obtained through Social Service Assessment interviews at intake and during hospital stay. Results: Among clients with no family history of mental illness, childhood neglect does not meaningfully affect the risk of negative versus positive schizophrenia. For clients with such history, on the other hand, neglect significantly raises the risk of schizophrenia with negative symptomatology. Conclusion: Our central finding is that risk for negative symptoms of schizophrenia are elevated by childhood neglect combined with a history of serious mental illness within the family. This is the only report to combine schizophrenic symptoms, familial risk and childhood neglect to date. Implications for primary prevention and treatment are discussed.
Is There a Genetic Predisposition to Anterior Cruciate Ligament Tear? A Systematic Review
Authors: John Rakesh , Dhillon Mandeep Singh , Sharma Siddhartha , Prabhakar Sharad , Bhandari Mohit 
Published: February 2016

Background: Injuries to the anterior cruciate ligament (ACL) are among the most common knee ligament injuries and frequently warrant reconstruction. The etiopathogenesis of these injuries has focused mainly on mechanism of trauma, patient sex, and anatomic factors as predisposing causes. Several genetic factors that could predispose to an ACL tear have recently been reported. Purpose: This systematic review summarizes the current evidence for a genetic predisposition to ACL tears. The principal research question was to identify genetic factors, based on the available literature, that could predispose an individual to an ACL tear. Study Design: Systematic review. Methods: The PubMed, EMBASE, Cochrane, and HuGE databases were searched; the search was run from the period of inception until June 21, 2015. A secondary search was performed by screening the references of full-text articles obtained and by manually searching selected journals. Articles were screened with prespecified inclusion criteria. The quality of studies included in the review was assessed for risk of bias by 2 reviewers using the Newcastle-Ottawa Scale. Results: A total of 994 records were identified by the search, out of which 17 studies (16 case-control studies and 1 cross-sectional study) were included in the final review. Two studies observed a familial predisposition to an ACL tear. Fourteen studies looked at specific gene polymorphisms in 20 genes, from which different polymorphisms in 10 genes were positively associated with an ACL tear. In addition to these polymorphisms, 8 haplotypes were associated with ACL tear. One study looked at gene expression analysis. Conclusion: Although specific gene polymorphisms and haplotypes have been identified, it is difficult to come to a conclusion on the basis of the existing literature. Several sources of bias have been identified in these studies, and the results cannot be extrapolated to the general population. More studies are needed in larger populations of different ethnicities. Gene-gene interactions and gene expression studies in the future may delineate the exact role of these gene polymorphisms in ACL tears.
Immediate Effects of a Brace on Gait Biomechanics for Predominant Lateral Knee Osteoarthritis and Valgus Malalignment After Anterior Cruciate Ligament Reconstruction
Authors: Hart Harvi F. , Collins Natalie J. , Ackland David C. , Cowan Sallie M. , Hunt Michael A. , Crossley Kay M. 
Published: February 2016

Background: Lateral knee osteoarthritis is notably common after anterior cruciate ligament reconstruction (ACLR). While valgus bracing has been investigated as an intervention for medial knee osteoarthritis (OA), little is known about the effectiveness of varus bracing for lateral knee OA after ACLR. Purpose: To determine the immediate effects of a varus unloader knee brace on gait biomechanics in people with lateral knee OA and valgus malalignment after ACLR. Study Design: Controlled laboratory study. Methods: Nineteen participants who had undergone primary ACLR 5 to 20 years previously and had symptomatic and radiographic lateral knee OA as well as valgus malalignment were included. Three-dimensional gait analyses were conducted during walking under 3 test conditions: (1) no brace, (2) unadjusted brace (sagittal plane support with neutral frontal plane adjustment), and (3) adjusted brace (sagittal plane support with varus adjustment). Knee, pelvis, hip, and ankle kinematics and moments data were statistically analyzed using repeated-measures analysis of variance (α = 0.05). Results: Compared with walking with no brace, the adjusted brace significantly increased peak knee flexion angle (mean difference [95% CI]: 3.2° [1.3° to 5.0°]) and adduction angle (1.7° [0.8° to 2.6°]) and reduced peak internal rotation angle (−3.0° [−4.0° to −2.0°]). Significant increases in peak knee flexion moment (0.14 N·m/kg [0.06 to 0.20 N·m/kg]), adduction moment (0.10 N·m/kg [0.07 to 0.14 N·m/kg]), and external rotation moment (0.01 N·m/kg [0.00 to 0.02 N·m/kg]) were observed with the adjusted brace. The adjusted brace also reduced peak hip adduction angle (−1.29° [−2.12 to −0.47]) and increased peak hip adduction (0.17 N·m/kg [0.04 to 0.31 N·m/kg]) and external rotation moments (0.09 N·m/kg [0.03 to 0.14 N·m/kg]). There were no significant differences between the adjusted and unadjusted brace conditions, except for knee internal rotation angle, where the adjusted brace produced significantly greater reductions relative to the unadjusted brace (−1.46° [−1.98 to −0.95]). Conclusion: Irrespective of frontal plane adjustment, the varus unloader brace produced immediate modulations in sagittal, frontal, and transverse plane joint angles and moments in younger individuals with lateral knee OA and valgus malalignment after ACLR. Clinical Relevance: The varus unloader brace may have the potential to mitigate abnormal knee joint mechanics associated with the development and progression of lateral knee OA after ACLR.
Improving Air Combat Maneuvering Skills Through Self-Study and Simulation-Based Practice
Authors: Petty Mikel D. , Barbosa Salvador E. 
Published: February 2016

Background. Although instructor participation is generally thought to improve the effectiveness of simulation-based training, trainees may have time and opportunity to practice skills in simulation when an instructor is not available. Aim. The question of whether complex psychomotor skills, such as air combat maneuvering, can be acquired and improved entirely without instructor assistance through self-study and simulation-based practice is investigated. Method. The results of an extended sequence of simulated air combat missions flown by a single experimental subject are reported and analyzed. Over a period of eight calendar years the subject flew 2,950 simulated air combat missions organized into 138 campaigns using seven different aircraft types. Throughout the period the subject studied air combat maneuvering in a self-guided, self-study mode and consciously used maneuvers and tactics learned during that study with the intent of improving his performance. However, determining whether the subject’s skills were actually improving over time was confounded by the fact that between some campaigns the subject changed the aircraft type he was flying as well as the aircraft types flown by the opposition, making direct campaign-to-campaign performance comparisons problematic. Consequently, a type-independent measure of performance was developed to normalize for the different aircraft types and allow direct comparison of performance across different aircraft types flown and opposed. Results. Two different nonparametric statistical tests were applied to the normalized performance measure across all campaigns. A third nonparametric statistical method was applied to victories within each aircraft type. All three showed statistically significant improvement in the subject’s skills over time despite the complete absence of instructor assistance. Conclusions. Although this case study must be considered anecdotal because it involves only a single experimental subject, it does provide an existence proof that self-guided self-study and simulation-based practice without an instructor can produce improvement in complex psychomotor skills in some learners. In addition, the analytical methods used to normalize for different aircraft types and test for improvement may be useful in similar situations where performance must be compared across time-varying circumstances.
MRI Evaluation of Achilles Tendon Rotation and Sural Nerve Anatomy
Authors: MacMahon Aoife , Deland Jonathan T. , Do Huong , Soukup Dylan S. , Sofka Carolyn M. , Demetracopolous Constantine A. , DeBlis Ryan 
Published: February 2016

Background: Limited-open and percutaneous Achilles tendon (AT) repair techniques have limited visibility, which may result in sural nerve violation and poor tendon targeting. The goal of this study was to assess the in vivo rotation of the AT and its distance to the sural nerve in ruptured and nonruptured ATs to develop guidelines to aid in limited-open and percutaneous repair techniques. Methods: A retrospective review was conducted to identify magnetic resonance imaging (MRI) studies of patients with ruptured and healthy (nonruptured) ATs. AT rotation and distance to the sural nerve in the anterior-posterior (A-P) and medial-lateral (M-L) planes were measured at the level of and proximal to the ankle. Results: The AT was externally rotated in both ruptured and nonruptured cohorts. Ruptured ATs showed greater external rotation than nonruptured ATs at the ankle (15.8 ± 16.2 degrees vs 5.9 ± 9.0 degrees, P = .008) but not at 10 cm proximal to the tendon’s insertion (10.9 ± 10.9 degrees vs 6.1 ± 8.4 degrees, P = .139). Proximal AT rotation was negatively correlated with rupture height ( r = −0.477, P = .029). At 4 cm proximal to the AT insertion, the sural nerve was closer anteriorly to and farther laterally from the AT in ruptures than in nonruptures ( P < .001). At 10 cm proximal to the AT insertion, the sural nerve was farther posteriorly and laterally from the AT in ruptures than in nonruptures ( P = .027 and P < .001, respectively). Conclusion: We found that the AT was more externally rotated in ruptured than in nonruptured tendons at the ankle and that its distance to the sural nerve differed between the 2 cohorts in the A-P and M-L planes, likely due to increased AT rotation and swelling with ruptures. To minimize sural nerve injury and improve tendon targeting, we suggest an external rotation of 11 degrees at the proximal end of the rupture and 16 degrees at the distal end when using percutaneous and limited-open AT repair devices to try to minimize sural nerve violation and increase tendon capture, which can decrease rates of complication and rerupture. Level of Evidence: Level III, retrospective comparative study.
Detection of wall and neck calcification of unruptured intracranial aneurysms with flat-detector computed tomography
Authors: Kizilkilic Osman , Huseynov Eldeniz , Kandemirli Sedat G , Kocer Naci , Islak Civan 
Published: February 2016

Object Microsurgical clipping is a widely used surgical technique in intracranial aneurysm treatment. It can be difficult in large sized aneurysms, and those with wide necks, thick walls and calcification located in the vicinity of the neck. This study reviewed calcification of the intracranial aneurysm wall and its relation to patient age, gender, location and size of the aneurysm. A possible cut-off value after which the aneurysm calcification rate increases was also investigated to classify patients’ risk factors for microclipping. Methods A retrospective review of all unruptured intracranial aneurysms that underwent digital subtraction angiography at a single centre was performed. Flat-detector computed tomography images of the aneurysm were reviewed for aneurysm location, size and calcification. The independent samples t test and χ2 test were used to show the relation between aneurysm wall calcification and patient age, gender, aneurysm localisation and size. Results None of the reviewed factors were statistically significantly related to aneurysm calcification except aneurysm size ( P < 0.01). Receiver operating characteristic curves showed aneurysms greater than 10.5 mm could be predicted to be calcified with a sensitivity of 80% and specificity of 63%. Conclusion In this study, the presence of calcification was related to aneurysm size. Larger aneurysms were more likely to be calcified. Aneurysms greater than 10.5 mm should be further investigated with a modality such as flat-detector computed tomography to show the calcification in detail, especially if microclipping is considered.
Spatial distribution mapping of drinking water fluoride levels in Karnataka, India: fluoride-related health effects
Authors: Chowdhury Chitta R , Shahnawaz Khijmatgar , Kumari Divya , Chowdhury Avidyuti , Bedi Raman , Lynch Edward , Harding Stewart , Grootveld Martin 
Published: February 2016

Objectives: (1) To estimate the concentrations of fluoride in drinking water throughout different zones and districts of the state of Karnataka. (2) To investigate the variation of fluoride concentration in drinking water from different sources, and its relationships to daily temperature and rainfall status in the regional districts. (3) To develop an updated fluoride concentration intensity map of the state of Karnataka, and to evaluate these data in the context of fluoride-related health effects such as fluorosis and their prevalence. Materials and Methods: Aqueous standard solutions of 10, 100 and 1,000 ppm fluoride (F−) were prepared with analytical grade Na+/F− and a buffer; TISAB II was incorporated in both calibration standard and analysis solutions in order to remove the potentially interfering effects of trace metal ions. This analysis was performed using an ion-selective electrode (ISE), and mean determination readings for n = 5 samples collected at each Karnataka water source were recorded. Results: The F− concentration in drinking water in Karnataka state was found to vary substantially, with the highest mean values recorded being in the north-eastern zone (1.61 ppm), and the lowest in the south-western one (only 0.41 ppm). Analysis of variance (ANOVA) demonstrated that there were very highly significant ‘between-zone’ and ‘between-districts-within-zones’ sources of variation ( p < 10−5–10−9), results consistent with a substantial spatial variance of water source F− levels within this state. Conclusions: The southern part of Karnataka has low levels of F− in its drinking water, and may require fluoridation treatment in order to mitigate for dental caries and further ailments related to fluoride deficiency. However, districts within the north-eastern region have contrastingly high levels of fluoride, an observation which has been linked to dental and skeletal fluorosis. This highlights a major requirement for interventional actions in order to ensure maintenance of the recommended range of fluoride concentrations (0.8–1.5 ppm) in Karnataka’s drinking water sources.
Accuracy of patient-reported range of elbow motion
Authors: Li Martin K-H , Robinson Paul M , van Rensburg Lee 
Published: February 2016

Background Patient-reported outcome meaures (PROMs) not only provide valuable insights into subjective indices of joint health, but also may provide limited objective information about range of motion (ROM). We sought to evaluate the accuracy of patient-reported range of elbow motion compared to measured ROM. Methods Sixty clinic patients were recruited, of whom 26 had elbow pathologies and 34 had pathologies other than at the elbow joint. Each patient independently estimated ROM for extension, flexion, pronation and supination before this was measured by a clinician using a universal goniometer, with the mean being the gold standard. Results We found that patients’ ROM estimates were significantly different from measured ROM ( p < 0.00001 at 95% confidence interval). There was no statistically significant difference between elbow pathology and non-elbow pathology patients’ estimated ROM. Conclusions There was great disparity between patient-estimated and measured ROM, although estimates of patients with known elbow pathology did not demonstrate any significant difference from their healthy counterparts. These differences may be too great for patient-estimated range of motion to be used as a reliable tool for assessing outcomes.
CABeRNET: a Cytoscape app for augmented Boolean models of gene regulatory NETworks
Authors: Paroni Andrea , Graudenzi Alex , Caravagna Giulio , Damiani Chiara , Mauri Giancarlo , Antoniotti Marco 
Published: February 2016

Abstract
Background
Dynamical models of gene regulatory networks (GRNs) are highly effective in describing complex biological phenomena and processes, such as cell differentiation and cancer development. Yet, the topological and functional characterization of real GRNs is often still partial and an exhaustive picture of their functioning is missing.

Results
We here introduce CABeRNET, a Cytoscape app for the generation, simulation and analysis of Boolean models of GRNs, specifically focused on their augmentation when a only partial topological and functional characterization of the network is available. By generating large ensembles of networks in which user-defined entities and relations are added to the original core, CABeRNET allows to formulate hypotheses on the missing portions of real networks, as well to investigate their generic properties, in the spirit of complexity science.

Conclusions
CABeRNET offers a series of innovative simulation and modeling functions and tools, including (but not being limited to) the dynamical characterization of the gene activation patterns ruling cell types and differentiation fates, and sophisticated robustness assessments, as in the case of gene knockouts. The integration within the widely used Cytoscape framework for the visualization and analysis of biological networks, makes CABeRNET a new essential instrument for both the bioinformatician and the computational biologist, as well as a computational support for the experimentalist. An example application concerning the analysis of an augmented T-helper cell GRN is provided.
“What Is Historical Poetics?”
Authors: Prins Yopie 
Published: February 2016

AbstractIn posing questions about what is “historical” and what counts as “poetics,” historical poetics cannot separate the practice of reading a poem from the histories and theories of reading that mediate our ideas about poetry. While nineteenth-century verse cultures revolved around reading by generic recognition, a reading of poetry as a form of cognition emerges among later critics like I. A. Richards, who illustrates how a line from Robert Browning is read in the mind’s eye, as if in the present tense. But Browning was already doing a version of historical poetics, in writing “Pan and Luna” as a poem about reading other poems about Pan, among them “A Musical Instrument,” by Elizabeth Barrett Browning. In the composition and reception of her poem, we see how Victorian poetry foregrounds its multiple mediations, including the mediation of voice by meter as a musical instrument. The recirculation of her popular poem through citation and recitation, illustration and anthologization, prosody and parody, demonstrates a varied history of thinking through—simultaneously “about” and “in”—verse.
European shags optimize their flight behavior according to wind conditions
Authors: Kogure Yukihisa , Sato Katsufumi , Watanuki Yutaka , Wanless Sarah , Daunt Francis 
Published: February 2016

ABSTRACT
Aerodynamics results in two characteristic speeds of flying birds: the minimum power speed and the maximum range speed. The minimum power speed requires the lowest rate of energy expenditure per unit time to stay airborne and the maximum range speed maximizes air distance traveled per unit of energy consumed. Therefore, if birds aim to minimize the cost of transport under a range of wind conditions, they are predicted to fly at the maximum range speed. Furthermore, take-off is predicted to be strongly affected by wind speed and direction. To investigate the effect of wind conditions on take-off and cruising flight behavior, we equipped 14 European shags Phalacrocorax aristotelis with a back-mounted GPS logger to measure position and hence ground speed, and a neck-mounted accelerometer to record wing beat frequency and strength. Local wind conditions were recorded during the deployment period. Shags always took off into the wind regardless of their intended destination and take-off duration was correlated negatively with wind speed. We combined ground speed and direction during the cruising phase with wind speed and direction to estimate air speed and direction. Whilst ground speed was highly variable, air speed was comparatively stable, although it increased significantly during strong head winds, because of stronger wing beats. The increased air speeds in head winds suggest that birds fly at the maximum range speed, not at the minimum power speed. Our study demonstrates that European shags actively adjust their flight behavior to utilize wind power to minimize the costs of take-off and cruising flight.