bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical characteristics and long-term follow-up of twin boys with de novo interstitial 1q25.2q25.3 deletion and 4q35.2 microduplication
Authors: Yang Aoyu , Fu Hao , Zhang Cai , Liang Yan 
Published: September 2024

Abstract

Background：Growth hormone deficiency (GHD) is the most prevalent form of pituitary hormone insufficiency.Genetic factors are increasingly recognized to play a significant role in the etiology of GHD.Deletions involving the long arm of chromosome 1 are rare, with only approximately 40 reported cases featuring detailed molecular characterization of deletion size and merely four instances involving deletions within region 1q25. and no related treatment has been reported
Case presentation：The identical twin boys were evaluated at the pediatric endocrinology clinic of Tongji Hospital due to a prolonged history (over 5 years) of short stature and cognitive delays. Upon diagnosis of GHD, hematuria, and intellectual disability, genome-wide CNV analysis revealed deletions at 1q25.2q25.3 and microduplications at 4q35.2 involving genes such as LHX4 and FAT1. These overlapping genomic alterations spanned 6.557 Mb and 141 Kb in these regions respectively, aligning with their clinical phenotypes.Furthermore, comprehensive exomic screening of 97 glomerular disease-associated genes showed no variations. Following diagnosis, the twins underwent over three years of rhGH therapy which led to significant catch-up growth and increased levels of IGF-1 and IGFBP3 without any adverse endocrine reactions or exacerbation of renal pathology.
Conclusions：This investigation delineates a novel syndromic manifestation in twin boys characterized by GHD, thin basement membrane nephropathy (TBMN),and intellectual disability associated with specific genetic alterations at 1q25.2-q25.3 and 4q35.2.The treatment with rhGH over an extended period was efficacious in promoting growth without discernible adverse effects underscoring its safety & effectiveness in this unique context.
Current practice of diagnosis and treatment for recto-urethral fistula in male patients with anorectal malformation: A multicenter questionnaire survey in Japan
Authors: Harumatsu Toshio , Murakami Masakazu , Sugita Koshiro , Ishimaru Tetsuya , Fujino Akihiro , Nakata Mitsuyuki , Aoi Shigeyoshi , Soh Hideki , Kinoshita Yoshiaki , Uchida Keiichi , Hirabayashi Takeshi , Fuchimoto Yasushi , Okajima Hideaki , Yonekura Takeo , Koshinaga Tsugumichi , Yagi Minoru , Matsufuji Hiroshi , Hirobe Seiichi , Nio Masaki , Ueno Shigeru , Iwai Jun , Kuroda Tatsuo , Ieiri Satoshi 
Published: September 2024

Abstract

Purpose
Surgical procedures for anorectoplasty for anorectal malformations (ARMs), particularly rectourethral fistula (RUF), depend on the institution. We investigated the diagnosis and treatment of RUF in male patients with ARMs in Japan using a questionnaire survey.
Methods
An online survey inquiring about the diagnosis and treatment (diagnostic modalities, surgical approaches, fistula dissection devices, and fistula closure techniques) of each type of ARM in male patients was conducted among institutional members of the Japanese Study Group of Anorectal Anomalies. Fisher's exact test was used to compare surgical methods between posterior sagittal anorectoplasty (PSARP) and laparoscopy-assisted anorectoplasty (LAARP).
Results
Sixty-one institutions (100%) completed the survey. LAARP was the preferred approach for high-type ARM (75.4%). PSARP was preferred for intermediate-type ARM (59.0%). Monopolar devices were most commonly used (72.1%) for RUF dissection. Blunt dissection was more frequent in the PSARP group (PSARP vs. LAARP: 55.6 vs. 20.0%, p < 0.005). Cystoscopy/urethroscopy to confirm the extent of dissection was used more frequently in the LAARP group (70.0% vs. 25.0%, p < 0.005). Clips and staplers were used more frequently in the LAARP group (p < 0.05).
Conclusion
Distinct fistula management strategies for PSARP and LAARP were revealed. Further studies are needed to investigate the postoperative outcomes associated with these practices.
Second Life in 15-Minute City
Authors: Aksoy Esma Selen , Venverloo Titus , Benson Tom , Duarte Fabio 
Published: September 2024

Abstract

Amsterdam has a housing shortage issue. To solve this problem, the Municipality aims to provide 73.660 housing units by 2028, either constructing new housing buildings or repurposing existing buildings which have other functions. The comparison between these two strategies, at the building scale, is the focus of several important research, from energy consumption in the construction process to the structural features of the repurposed buildings and their compatibility with the housing plan. However, the urban scale has seldom been studied when comparing new and repurposed housing projects. In this paper we compare access to the number and diversity of amenities between new and repurposed housing buildings, based on their location in the city. For this, we evaluate amenities within a 15-minute walking distance from each of the 38,061 housing units (554 residential buildings) built between 2015 and 2019. Additionally, we compare whether these amenities are mainly targeted to tourists or residents. Our results contribute to policymakers and urban planners in evaluating how residents in new and repurposed housing projects benefit from their insertion in the city.
Overexpression of a mango MiUBRPS27a gene increases the resistance to low temperature, drought and salt stress in Arabidopsis
Authors: Qin LiuFei , Zhang YiLi , Mo WenJing , Zhu JiaWei , Guo TianLi , He XinHua , Luo Cong 
Published: September 2024

Abstract

Ubitidin-ribosomal protein plays an important regulatory role in protein synthesis, protein degradation, transcriptional processing, and apoptosis regulation, thus involved in plant growth and stress response. At present, no ubitidin-ribosomal gene has been reported in mango. In a previous study, a ubiquitin-ribosomal gene named MiUBRPS27a was obtained from cDNA-SCoT differential display analysis under different stress treatments of mango. In this study, the expression pattern and function of MiUBRPS27a were studied. The results showed that MiUBRPS27a was expressed in all tested tissues, among which the highest expression level was found in leaves. The expression of MiUBRPS27a gene was affected by low temperature, drought, and salt stress treatments. Overexpression of MiUBRPS27a significantly increased the root length in Arabidopsis under low temperature, drought and salt stress treatments. MiUBRPS27a transgenic plants showed decreased the content of malondialdehyde (MAD) and hydrogen peroxide (H2O2), increased the activity of superoxide dismutase (SOD) and proline content, thus increased the survival rate of transgenic Arabidopsis plants under drought stress. Our results suggest that MiUBRPS27a gene plays an important role in plant response to stress.
Effect of porosity and pore size on the corrosion and compression behaviour of biomedical porous titanium fabricated via space holder technique with spark plasma sintering
Authors: Makena Isaac M , Shongwe Mxolisi B , Motsi Glenda T 
Published: September 2024

Abstract

Titanium alloys' exceptional mechanical qualities, remarkable corrosion resistance, and biocompatibility have made them popular choices for use as metallic materials in medical applications. Since solid titanium alloys have a larger elastic modulus than real human bones, porous titanium alloys are used in place of solid titanium alloys to get results that are comparable to those of human bones and meet orthopedic requirements. In this work, porous titanium was fabricated using powder metallurgy processes to study the effects of porosity and pore size on the compressive strength and electrochemical response. To obtain foams with varying pore features, the content of NaCl was varied between 0–80 vol. %. Furthermore, NaCl particles of varying sizes between 100 and 600 µm were employed. Subsequently, specimens underwent preparations for analysis using optical microscopy and scanning electron microscopy to examine the microstructure. Additionally, 3D X-ray micro-CT scanning was used to provide detailed information on the foam porosities. The pore size of the sample affects its corrosion resistance against the 0.9 wt.%. NaCl solution and the lowest corrosion rate were recorded with the sample having the finest pores. Instead, with compressive strength the trend goes the other way round, i.e., strength increases with pore size. As expected, the compressive strength of the porous titanium was found to be showing a linear relationship with porosity.
The relationship between Stressful Life Events and Anxiety Symptoms: A cross-sectional survey of with university students in Botswana
Authors: Amone-P'Olak Kennedy , Omech Bernard 
Published: September 2024

Abstract

Background: Anxiety disorders, particularly in young adults, have a severe influence on the quality of life, career growth, and health. There is a dearth of research on causes and correlates, particularly in areas with limited resources. At a premier higher education institution in Botswana, we set out to determine how stressful life events (SLEs) predict anxiety symptoms in young adults.
Method: In a cross-sectional survey (n = 615, mean age = 21.1, ± 2.1, 59.3% female), the 21-item Beck’s Anxiety Inventory (BAI) and the 26-Item Social Readjustment Rating Scale were used to assess anxiety symptoms and SLEs, respectively. T-tests, analyses of variance (ANOVA) and regression analyses were used to calculate associations, compare SLEs at different levels of anxiety symptoms, and assess whether SLEs predicted anxiety.
Results: Anxiety symptoms were moderate in 16.4% and severe in 11.7% of respondents. Over 50 per cent of respondents reported eight (8) or more SLEs. Higher numbers of SLEs were associated with a gradual increase in anxiety symptoms severity. Respondents at different levels of anxiety differed significantly in reporting SLEs (F (3, 612) = 68.21, p < .001). SLEs significantly predicted reporting anxiety symptoms (β = .56, 95% CI: 0.45, 0.66). When all SLEs were simultaneously included in one model, SLEs related to personal, study and relationship stressors independently predicted anxiety symptoms.
Conclusion: Anxiety in young individuals is highly correlated with reporting SLEs. Practitioners should prioritise initiatives that promote mental health through effective low-cost self-help interventions for easing anxiety symptoms in young adults.
Yield reductions in rapeseed, Brassica napus, in response to various regimes of simulated defoliation
Authors: Eskandarlee Karim , Iranipour Shahzad , Peyghamzadeh Kamal , Saber Moosa , Michaud JP 
Published: September 2024

Abstract

Defoliation by insects is a major source of damage in field crops such as canola and an economic evaluation of resulting yield losses is essential for guiding management decisions. In this study, different intensities of defoliation were simulated at different growth stages of rapeseed plants in three sets of experiments. In the first experiment, 25, 50, or 75% of the leaf area was removed once at either the 2-, 4- or 8-leaf stage. In the second experiment, similar defoliation treatments were imposed at one of four flowering stages, pre-bloom, early bloom, mid-bloom, or late bloom. In the third experiment, 80% of leaf area was removed progressively in three treatments: 10% defoliation weekly throughout the 8-week period of flowering, 20% defoliation in each of the first 4 weeks, and 20% defoliation in each of the last 4 weeks. In all experiments, various plant metrics, components of yield, and seed yields per unit area were compared to undefoliated (control) plants. Plant phenology (onset of flowering, time to flowering, and ripening time) was delayed, and growth and yield components were reduced by defoliation occuring in vegetative, prebloom and early bloom stages, but plants compensated for up to 25% defoliation that occurred mid to late flowering. The economic injury level (EIL) was determined to be 3.7, 5.5, and 5.7% defoliation at the 2-, 4- and 8-leaf stages respectively, whereas it was < 2% just prior to flowering and 5.6% during early bloom. Moderate levels of defoliation late in the flowering period resulted in some overcompensation (yields greater than controls). The economic threshold for defoliation during flowering was calculated to be 3.2 and 3.7% for gradual and sudden defoliation events, respectively. These findings can be linked to leaf consumption by defoliators to aid decision making by farmers.
Clinical outcomes of early revascularization in severe diabetic foot ulcer with ischemia: a single center experience
Authors: Tofigh Arash Mohammadi , Samsami Majid , Toutounchi Alireza Haghbin , Hosseini Seyed Pedram Kouchak , Khoshnoudi Hojatolah , Lemraski Soheil Bagherian 
Published: September 2024

Abstract

Objective: The effect of early revascularization on preventing amputation of diabetic foot ulcers (DFU) patients is challenging. This study aimed to evaluate the impact of early revascularization in ischemic severe DFU outcomes.
Methods: This prospective cohort study was conducted on 30 patients with severe DFU (Wound Wagner grade 4 and 5), and peripheral artery disease referred to Imam Hossein Hospital in Tehran, Iran, from April 2020 to March 2022. All patients underwent lower limb vascular surgery. Patients were examined for 20 months regarding wound healing, amputation, and death. Data were analyzed by SPSS statistic version 27.
Results: The present study included 30 patients (30 lower limbs). The mean time of patients’ follow-up to outcome was 12.56 (SD=4.36, 3-20) months. The mean wait time to revascularization was 8.90 (SD= 2.32, 6-15) weeks. Nine patients (30%) waited more than nine weeks for revascularization. Totally 14 patients (46.7%) healed without major amputation. A shorter time to revascularization (9 weeks and less) was significantly related to a higher probability of healing without major amputation over time (P value= 0.017).
Conclusion: The results of the present study showed that shorter waiting time for vascular intervention in patients with severe DFU and ischemia is related to wound healing in patients without the need for major amputation. It seems necessary to conduct more studies about the time of vascular intervention in this group of patients.
Detection of Dementia: Using Electroencephalography and Machine Learning
Authors: Ahmed Tanveer , Gebali Fayez , Elmiligi Haytham , Elhadad Mohamed K. 
Published: September 2024

Introduction
This article serves as a background to an emerging field and aims to investigate the use of Electroencephalography signals in detecting dementia. It offers a promising approach for individuals with dementia, as electroencephalography provides a non-invasive measure of brain activity during language tasks. Method: The methodological core of this study involves implementing various electroencephalography feature extraction and selection techniques, along with the use of machine learning algorithms for analyzing the signals to identify patterns indicative of dementia. In terms of results, our analysis showed that most individuals likely to have dementia are in the 60-69 age bracket, with a higher incidence in females. Result: Notably, the K-means algorithm achieved the highest Silhouette Score at approximately 0.295. Additionally, Decision Tree and Random Forest models achieved the best accuracy at 95.83%, slightly outperforming the support vector machines and Logistic Regression models, which also showed good accuracy at 91.67%. Conclusion: The conclusion drawn from this article is that electroencephalography signals, analyzed with machine learning algorithms, can be effectively used to detect dementia, with Decision Tree and Random Forest models showing promise for future non-invasive diagnostic tools.
Perempuan dalam pemberdayaan sosial di Komunitas Pelangi Nusantara Malang
Authors: Sartika Emilia Nanda , Widianto Ahmad Arif 
Published: September 2024

Penelitian mengkaji bentuk partisipasi perempuan dalam pemberdayan sosial di Komunitas Pelangi Nusantara Malang (Pelanusa). Penelitian menggunakan metode kualitatif melibatkan founder, pembina, ketua tim kreatif, anggota tim kreatif, dan anggota binaan di Pelanusa. Hasil penelitian menunjukkan partisipasi aktif peserta perempuan dalam kegiatan kewirausahaan sosial dan pendampingan pada program pelatihan pembuatan produk kerajinan pembekalan kewirausahaan. Namun, disamping keterbatasan sumber daya di Pelanusa, kemauan dan kemampuan dasar peserta perempuan sedikit banyak menghambat partisipasi aktif mereka. Selain itu, beberapa peserta tidak mendapat dukungan penuh dari keluarga termasuk tidak sepernuhnya diizinkan oleh suami untuk terlibat di Pelanusa.
Cancel culture pelaku pelecehan seksual di media sosial
Authors: Hasna Asyifa Amalia , Hendratomo Grendi 
Published: September 2024

Penelitian mengivestigasi cancel culture pelaku pelecehan seksual di media sosial sebagai salah satu respon terhadap penanganan kasus pelecehan seksual di Indonesia yang belum maksimal. Dengan keterbatasan pemahaman dan pengetahuan masyarakat tentang perilaku jahat dan juga tentang cancel culture, sehingga masih pro-kontra marak dalam masyarakat. Hasil penelitian menunjukkan cancel culture dimaknai sebagai bentuk boikot dan pemberhentian karir seseorang karena dianggap melanggar nilai dan norma masyarakat dan meningkatkan kesadaran dan kewaspadaan terkait isu pelecehan seksual. Namun terdapat relasi kuasa oleh pelaku pelecehan seksual yang memiliki status sosial tinggi sehingga mempengaruhi dampak maupun keberhasilan dari cancel culture itu sendiri. Gerakan cancel culture belum sepenuhnya efektif diberlakukan untuk melawan pelecehan seksual karena khalayak tidak sepenuhnya memahami cancel culture dan masih kuatnya budaya patriakhi dalam masyarakat Indonesia. Research investigates the cancel culture of sexual harassment perpetrators on social media as a response to the inadequate handling of sexual harassment cases in Indonesia. With limited public understanding and knowledge about evil behavior and also about cancel culture, pros and cons are still widespread in society. The research results show that cancel culture is interpreted as a form of boycott and termination of a person's career because it is deemed to violate societal values and norms and increases awareness and vigilance regarding the issue of sexual harassment. However, there are power relations between perpetrators of sexual harassment who have high social status, which influences the impact and success of cancel culture itself. The cancel culture movement has not been fully effective in fighting sexual harassment because the public does not fully understand cancel culture and the strong patriarchal culture in Indonesian society.
The Validity of Impressions as a Media Dose Metric in a Tobacco Public Education Campaign Evaluation: Observational Study
Authors: Davis Kevin , Curry Laurel , Bradfield Brian , Stupplebeen David A , Williams Rebecca J , Soria Sandra , Lautsch Julie 
Published: September 2024

Background
Evaluation research increasingly needs alternatives to target or gross rating points to comprehensively measure total exposure to modern multichannel public education campaigns that use multiple channels, including TV, radio, digital video, and paid social media, among others. Ratings data typically only capture delivery of broadcast media (TV and radio) and excludes other channels. Studies are needed to validate objective cross-channel metrics such as impressions against self-reported exposure to campaign messages.

Objective
This study aimed to examine whether higher a volume of total media campaign impressions is predictive of individual-level self-reported campaign exposure in California.

Methods
We analyzed over 3 years of advertisement impressions from the California Tobacco Prevention Program’s statewide tobacco education campaigns from August 2019 through December 2022. Impressions data varied across designated market areas (DMAs) and across time. These data were merged to individual respondents from 45 waves of panel survey data of Californians aged 18-55 years (N=151,649). Impressions were merged to respondents based on respondents’ DMAs and time of survey completion. We used logistic regression to estimate the odds of respondents’ campaign recall as a function of cumulative and past 3-month impressions delivered to each respondent’s DMA.

Results
Cumulative impressions were positively and significantly associated with recall of each of the Flavors Hook Kids (odds ratio [OR] 1.15, P<.001), Dark Balloons and Apartment (OR 1.20, P<.001), We Are Not Profit (OR 1.36, P<.001), Tell Your Story (E-cigarette, or Vaping, product use Associated Lung Injury; OR 1.06, P<.05), and Thrown Away and Little Big Lies (OR 1.05, P<.01) campaigns. Impressions delivered in the past 3 months were associated with recall of the Flavors Hook Kids (OR 1.13, P<.001), Dark Balloons and Apartment (OR 1.08, P<.001), We Are Not Profit (OR 1.14, P<.001), and Thrown Away and Little Big Lies (OR 1.04, P<.001) campaigns. Past 3-month impressions were not significantly associated with Tell Your Story campaign recall. Overall, magnitudes of these associations were greater for cumulative impressions. We visualize recall based on postestimation predicted values from our multivariate logistic regression models.

Conclusions
Variation in cumulative impressions for California Tobacco Prevention Program’s long-term multichannel tobacco education campaign is predictive of increased self-reported campaign recall, suggesting that impressions may be a valid proxy for potential campaign exposure. The use of impressions for purposes of evaluating public education campaigns may help address current methodological limitations arising from the fragmented nature of modern multichannel media campaigns.
Nonprescription antimicrobial use during the COVID-19 pandemic: a systematic review
Authors: Karolina Sinta , Sulistiadi Wahyu 
Published: September 2024

Purpose: Restrictions on mobility, confusion of information, and the lack of scientific evidence related to the treatment of COVID-19 have implications for the emergence of self-medication behavior in the community, especially the use of antimicrobials without a prescription. This study aims to describe the pattern of non-prescription antimicrobial use during the COVID-19 pandemic.
Methods: A systematic review was conducted on articles published between 2020-2022 from 3 databases: Embase, Scopus, and Science Direct, examining the use of over-the-counter antimicrobials during the COVID-19 pandemic.
Results: 13 relevant studies reviewed usage patterns, including self-medication behavior and antimicrobial dispensing practices without a prescription.
Conclusion: The panic during the COVID-19 pandemic triggered the over-the-counter use of antimicrobials without a prescription, both as an effort to prevent and reduce symptoms. The role of community pharmacists and the government is urgently needed to overcome this.