bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of targeted neonatal echocardiography consultations for critically sick preterm neonates
Authors: Joye Sébastien , Kharrat Ashraf , Zhu Faith , Deshpande Poorva , Baczynski Michelle , Jasani Bonny , Lee Seungwoo , Mertens Luc L , McNamara Patrick J , Shah Prakesh S , Weisz Dany E , Jain Amish 
Published: September 2024

Rationale
Preterm neonates needing rescue treatments with inotropes and/or inhaled nitric oxide (iNO) (acute critical illnesses, ACIs) in neonatal intensive care units (NICUs) are at high risk of mortality. While targeted neonatal echocardiography consultations (TNE) are increasingly used to guide management, its clinical impact need evaluation.

Objectives
To investigate clinical outcomes in relation to TNE utilisation during episodes of ACIs among preterm neonates.

Methods
This retrospective cohort study, conducted at two tertiary NICUs over 10 years, included neonates<37 weeks gestational age (GA) who developed ACIs. Patients receiving TNE-guided care (TNE within 24 hours of treatment initiation) were compared with non-TNE management. Outcomes included predischarge mortality, episode-related mortality (<7 days) and a new diagnosis of intraventricular haemorrhage≥grade 3 (IVH-3). Inverse probability of treatment weighting (IPTW) using propensity score was used to account for confounders, including site, birth years and baseline illness severity.

Measurements and main results
Of 622 included patients, 297 (48%) had TNE; median (IQR) GA at ACI was 26.4 (25.0–28.4) weeks. TNE group demonstrated higher baseline mean airway pressure, oxygen requirement and heart rate and frequently received both inotrope and iNO during ACI. IPTW analysis revealed TNE was associated with lower mortality (adjusted OR (95% CI) 0.75 (0.59 to 0.95)), episode-related mortality (0.54 (0.40 to 0.72)) and death or IVH-3 (0.78 (0.62 to 0.99)). TNE group received more varied inotropic agents, demonstrated earlier improvements in blood pressures, without increasing overall inotrpoic burden.

Conclusions
Among preterm neonates requiring rescue treatments with inotropes/iNO, TNE utilisation to guide clinical management may be associated with improved survival.
Coronary artery complications in patients with Kawasaki disease who successfully responded to the standard initial IVIG treatment
Authors: Takaki Sotaro , Kobayashi Tohru , Kuwabara Masanari , Kato Naoto , Kosami Koki , Ae Ryusuke 
Published: September 2024

Objectives
To identify clinical characteristics of patients with non-refractory Kawasaki disease (KD), which were defined as those who successfully responded to the standard initial intravenous immunoglobulin (IVIG) treatment (2 g/kg/day, single infusion) without any secondary or later additional specific treatments, and to investigate the factors associated with the development of coronary artery (CA) complications in patients with non-refractory KD.

Design
Retrospective cohort study.

Setting
Hospitals specialising in paediatrics and hospitals with ≥100 beds and a paediatric department throughout Japan.

Patients
A total of 122 489 patients who developed KD across Japan during 2011–2018.

Main outcome measures
CA abnormalities identified after acute illness of KD (defined as CA sequelae).

Results
A total of 69 735 patients with non-refractory KD were identified, of which 672 (0.96%) experienced CA sequelae. Among patients with non-refractory KD, the presence of CA abnormalities identified at initial echocardiographic assessment was strongly associated with CA sequelae (adjusted OR (95% CI): 37.8 (31.9 to 44.7)). CA sequelae was also associated with male patients, infants (<12 months old), older patients (≥60 months old) and patients who received delayed initial IVIG treatment (>7 days from KD onset). Subgroup analyses demonstrated that delayed initial IVIG treatment was significantly associated with the development of CA sequelae in both patients with and without CA abnormalities identified at initial echocardiographic assessment.

Conclusions
Approximately 1% of patients with non-refractory KD may develop CA sequelae. Our findings highlight the importance of initial echocardiographic assessment and early initiation of IVIG treatments for patients with KD.
Association between psychological resilience and all-cause mortality in the Health and Retirement Study
Authors: Zhang Aijie , Zhou Liqiong , Meng Yaxian , Ji Qianqian , Ye Meijie , Liu Qi , Tan Weiri , Zheng Yeqi , Hu Zhao , Liu Miao , Xu Xiaowei , Karlsson Ida K. , Hägg Sara , Zhan Yiqiang 
Published: September 2024

BackgroundPsychological resilience refers to an individual’s ability to cope with and adapt to challenging life circumstances and events.ObjectiveThis study aims to explore the association between psychological resilience and all-cause mortality in a national cohort of US older adults by a cross-sectional study.MethodsThe Health and Retirement Study (2006–2008) included 10 569 participants aged ≥50. Mortality outcomes were determined using records up to May 2021. Multivariable Cox proportional hazards models were used to analyse the associations between psychological resilience and all-cause mortality. Restricted cubic splines were applied to examine the association between psychological resilience and mortality risk.FindingsDuring the follow-up period, 3489 all-cause deaths were recorded. The analysis revealed an almost linear association between psychological resilience and mortality risk. Higher levels of psychological resilience were associated with a reduced risk of all-cause mortality in models adjusting for attained age, sex, race and body mass index (HR=0.750 per 1 SD increase in psychological resilience; 95% CI 0.726, 0.775). This association remained statistically significant after further adjustment for self-reported diabetes, heart disease, stroke, cancer and hypertension (HR=0.786; 95% CI 0.760, 0.813). The relationship persisted even after accounting for smoking and other health-related behaviours (HR=0.813; 95% CI 0.802, 0.860).ConclusionsThis cohort study highlights the association between psychological resilience and all-cause mortality in older adults in the USA.Clinical implicationsPsychological resilience emerges as a protective factor against mortality, emphasising its importance in maintaining health and well-being.
Racial disparities in end-of-life suffering within surgical intensive care units
Authors: Haddad Diane N , Meredyth Nicole , Hatchimonji Justin , Merulla Elizabeth , Matta Amy , Saucier Jason , Sharoky Catherine E , Bass Gary Alan , Pascual Jose L , Martin Niels D 
Published: September 2024

BackgroundEnd-of-life (EOL) care is associated with high resource utilization. Recognizing and effectively communicating that EOL is near promotes more patient-centered care, while decreasing futile interventions. We hypothesize that provider assessment of futility during the surgical intensive care unit (SICU) admission would result in higher rates of Do Not Resuscitate (DNR).MethodsWe performed a retrospective review of a prospective SICU registry of all deceased patients across a health system, 2018–2022. The registry included a subjective provider assessment of patient’s expected survival. We employed multivariable logistic regression to adjust for clinical factors while assessing for association between code status at death and provider’s survival assessment with attention to race-based differences.Results746 patients—105 (14.1%) traumatically injured and 641 (85.9%) non-traumatically injured—died over 4.5 years in the SICU (mortality rate 5.9%). 26.3% of these deaths were expected by the ICU provider. 40.9% of trauma patients were full code at the time of death, compared with 15.6% of non-traumatically injured patients. Expected death was associated with increased odds of DNR code status for non-traumatically injured patients (OR 1.8, 95% CI 1.03 to 3.18), but not for traumatically injured patients (OR 0.82, 95% CI 0.22 to 3.08). After adjusting for demographic and clinical characteristics, black patients were less likely to be DNR at the time of death (OR 0.49, 95% CI 0.32 to 0.75).Conclusion20% of patients who died in our SICU had not declared a DNR status, with injured black patients more likely to remain full code at the time of death. Further evaluation of this cohort to optimize recognition and communication of EOL is needed to avoid unnecessary suffering.Level of evidenceLevel III/prognostic and epidemiological.
Data from Eftilagimod Alpha (Soluble LAG3 Protein) Combined with Pembrolizumab as Second-Line Therapy for Patients with Metastatic Head and Neck Squamous Cell Carcinoma
Authors: Forster Martin , Brana Irene , Pousa Antonio L. , Doger Bernard , Roxburgh Patricia , Bajaj Pawan , Peguero Julio , Krebs Matthew , Carcereny Enric , Patel Grisma , Mueller Christian , Brignone Chrystelle , Triebel Frederic 
Published: September 2024

<div>AbstractPurpose:<p>Eftilagimod alpha (efti), a soluble LAG3 protein, activates antigen-presenting cells (APC) and downstream T cells. TACTI-002 (part C) evaluated whether combining efti with pembrolizumab led to strong antitumor responses in patients with second-line recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) while demonstrating good tolerability.</p>Patients and Methods:<p>In this multinational phase II trial using Simon’s two-stage design, patients who were PD-L(1)-naïve with R/M HNSCC who had failed first-line platinum-based therapy, unselected for PD-L1, received intravenous pembrolizumab (200 mg, once every 2 weeks) combined with subcutaneous efti (30 mg once every 2 weeks for 24 weeks and once every 3 weeks thereafter). The primary endpoint was objective response rate per RECIST 1.1 modified for immune-based therapy by investigator assessment. Additional endpoints included duration of response, progression-free survival, overall survival, and tolerability. Pharmacodynamic effects (absolute lymphocyte count) and Th1 cytokine biomarkers (IFNγ/CXCL10)] were evaluated in liquid biopsies.</p>Results:<p>Between March 2019 and January 2021, 39 patients were enrolled; 37 were evaluated for response. All patients received prior chemotherapy, and 40.5% were pretreated with cetuximab; 53.1% of patients had PD-L1 combined positive score <20. With a median follow-up of 38.8 months, the objective response rate was 29.7%, including 13.5% complete responders. The median duration of response was not reached. Rapid and sustained absolute lymphocyte count increase was observed in patients who had an objective response. Th1 biomarkers increased sustainably after first treatment. No unexpected safety signals were observed.</p>Conclusions:<p>Efti plus pembrolizumab was safe and showed encouraging antitumor activity and pharmacodynamic effects in patients with second-line head and neck squamous cell carcinoma (HNSCC), thus supporting further evaluation of this combination in earlier treatment lines.</p></div>
NCI’s Proteomic Data Commons: A Cloud-Based Proteomics Repository Empowering Comprehensive Cancer Analysis through Cross-Referencing with Genomic and Imaging Data
Authors: Thangudu Ratna R. , Holck Michael , Singhal Deepak , Pilozzi Alexander , Edwards Nathan , Rudnick Paul A. , Domagalski Marcin J. , Chilappagari Padmini , Ma Lei , Xin Yi , Le Toan , Nyce Kristen , Chaudhary Rekha , Ketchum Karen A. , Maurais Aaron , Connolly Brian , Riffle Michael , Chambers Matthew C. , MacLean Brendan , MacCoss Michael J. , McGarvey Peter B. , Basu Anand , Otridge John , Casas-Silva Esmeralda , Venkatachari Sudha , Rodriguez Henry , Zhang Xu 
Published: September 2024

Abstract

Proteomics has emerged as a powerful tool for studying cancer biology, developing diagnostics, and therapies. With the continuous improvement and widespread availability of high-throughput proteomic technologies, the generation of large-scale proteomic data has become more common in cancer research, and there is a growing need for resources that support the sharing and integration of multi-omics datasets. Such datasets require extensive metadata including clinical, biospecimen, and experimental and workflow annotations that are crucial for data interpretation and reanalysis. The need to integrate, analyze, and share these data has led to the development of NCI’s Proteomic Data Commons (PDC), accessible at https://pdc.cancer.gov. As a specialized repository within the NCI Cancer Research Data Commons (CRDC), PDC enables researchers to locate and analyze proteomic data from various cancer types and connect with genomic and imaging data available for the same samples in other CRDC nodes. Presently, PDC houses annotated data from more than 160 datasets across 19 cancer types, generated by several large-scale cancer research programs with cohort sizes exceeding 100 samples (tumor and associated normal when available). In this article, we review the current state of PDC in cancer research, discuss the opportunities and challenges associated with data sharing in proteomics, and propose future directions for the resource.

Significance:
The Proteomic Data Commons (PDC) plays a crucial role in advancing cancer research by providing a centralized repository of high-quality cancer proteomic data, enriched with extensive clinical annotations. By integrating and cross-referencing with complementary genomic and imaging data, the PDC facilitates multi-omics analyses, driving comprehensive insights, and accelerating discoveries across various cancer types.
РЕЗУЛЬТАТИ ПРОГНОЗУВАННЯ ВЕНОЗНИХ ТРОМБОЗІВ ТА ЕМБОЛІЙ ПРИ ЛІКУВАННІ ГОСТРОГО КАЛЬКУЛЬОЗНОГО ХОЛЕЦИСТИТУ
Authors: КОРОЛЬ Я. А. , КАВКА М. Р. , ФЕДЧИШИН Н. Р. 
Published: September 2024

Мета роботи: поліпшення результатів лікування пацієнтів із гострим калькульозним холециститом і його ускладненнями шляхом диференційної профілактики венозних тромбозів та емболій за рахунок використання опрацьованої прогностичної моделі визначення ступеня їх ризику.
Матеріали і методи. У ході дослідження проаналізовано результати обстеження та лікування 101 пацієнта з гострим калькульозним холециститом та його ускладненнями за період з 2021 по 2022 роки на базі кафедри хірургії, пластичної хірургії та ендоскопії ФПДО Львівського національного медичного університету імені Данила Галицького (КНП 1 ТМО м. Львів, відділення хірургії та онкології № 2). Переважали жінки (69 осіб, 68,3 %) віком від 24 до 86 років (середній вік (59,0±15,29) років). Пацієнтів поділили залежно від виникнення ускладнень захворювання (34 хворих, 33,7 %) чи їх відсутності. Ускладнення включали здебільшого поєднання гострого калькульозного холециститу з протоковою патологією. Уся вибірка хворих підлягала клінічному, лабораторному та інструментальному дослідженню. У результаті виконаних обстежень і узагальнення даних виявлено 3 (21,4 %) випадки тромбозу в венах гомілок та суральних синусів, 2 (14,3 %) – підколінної вени, 2 (14,3 %) – поверхневої стегнової вени, 2 (14,3 %) – загальної стегнової і 3 (21,4 %) – клубових вен.
Результати. У результаті дослідження та статистичного аналізу було виокремлено 9 факторів, які мають достовірний вплив на виникнення венозних тромбозів й емболій: інтерлейкіни 1β та 4, TNF, протромбіновий індекс, загальний фібриноген, МНВ, D-димери, значення шкал Caprini і Rogers. Розроблено формули для визначення вірогідності розвитку тромботичних ускладнень з гострим неускладненим та ускладненим калькульозним холециститом відповідно. Впровадження у клініці створених об’єктивізованих прогностичних моделей визначення ризику виникнення венозних тромбозів та емболій та застосування способу профілактики у пацієнтів із гострим калькульозним холециститом і його ускладненнями дало змогу сигніфікантно знизити частоту цих ускладнень загалом з 32,7 % до 11,5 %, при неускладнених випадках з 12,1 % до 5,1 % та при ускладнених – з 43,8 % до 15,4 % (р<0,05).
Derechas y acción política empresarial del sector agropecuario en Argentina (2015-2019) y en Paraguay (2013-2018)
Authors: Nikolajczuk Monica Susana 
Published: September 2024

El artículo se propone reconstruir el vínculo entre derechas y elite económica en Argentina y Paraguay a través del estudio de la acción política empresarial agropecuaria durante los gobiernos de Mauricio Macri (2015-2019) y de Horacio Cartes (2013-2018). La hipótesis es que la dimensión que determina el tipo predominante de acción política empresarial del sector agropecuario es la dirección política ideológica de los gobiernos en ejercicio del poder del Estado. Mientras que durante los gobiernos populistas-progresistas en los países bajo estudio, el empresariado agropecuario ponderó la dimensión corporativa y el conflicto político, volviéndose la estrategia prioritaria; con el ascenso de las derechas al poder en Argentina (2015) y Paraguay (2013), se priorizó la estrategia de articulación institucional en el Poder Ejecutivo a través de los mecanismos de circulación de trayectorias desde el ámbito privado, relegando a un plano secundario el accionar contencioso de las organizaciones empresariales. Desarrollaremos una metodología comparativa, puesto que el proyecto pretende contribuir a una carencia en el campo de estudios, desarrollando explicaciones a la vez individualizadoras y generalizadoras del fenómeno
Generating Sonic Phantoms with Quadratic Difference Tone Spectrum Synthesis
Authors: Gutiérrez Esteban , Haworth Christopher , Cádiz Rodrigo F. 
Published: September 2024

Abstract
Quadratic difference tones belong to a family of perceptual phenomena that arise from the neuromechanics of the auditory system in response to particular physical properties of sound. Long deployed as “ghost” or “phantom” tones by sound artists, improvisers, and computer musicians, in this article we address an entirely new topic: How to create a quadratic difference tone spectrum (QDTS) in which a target fundamental and harmonic overtone series are specified and in which the complex tone necessary to evoke it is synthesized. We propose a numerical algorithm that solves the problem of how to synthesize a QDTS for a target distribution of amplitudes. The algorithm aims to find a solution that matches the desired spectrum as closely as possible for an arbitrary number of target harmonics. Results from experiments using different parameter settings and target distributions show that the algorithm is effective in the majority of cases, with at least 99% of the cases being solvable in real time. An external object for the visual programming language Max is described. We discuss musical and perceptual considerations for using the external, and we describe a range of audio examples that demonstrate the synthesis of QDTSs across different cases. As we show, the method makes possible the matching of QDTSs to particular instrumental timbres with surprising efficiency. Also included is a discussion of a musical work by composer Marcin Pietruszewski that makes use of QDTS synthesis.
Segregation-to-integration transformation model of memory evolution
Authors: Bavassi Luz , Fuentemilla Lluís 
Published: September 2024

Abstract
Memories are thought to use coding schemes that dynamically adjust their representational structure to maximize both persistence and efficiency. However, the nature of these coding scheme adjustments and their impact on the temporal evolution of memory after initial encoding is unclear. Here, we introduce the Segregation-to-Integration Transformation (SIT) model, a network formalization that offers a unified account of how the representational structure of a memory is transformed over time. The SIT model asserts that memories initially adopt a highly modular or segregated network structure, functioning as an optimal storage buffer by balancing protection from disruptions and accommodating substantial information. Over time, a repeated combination of neural network reactivations involving activation spreading and synaptic plasticity transforms the initial modular structure into an integrated memory form, facilitating intercommunity spreading and fostering generalization. The SIT model identifies a nonlinear or inverted U-shaped function in memory evolution where memories are most susceptible to changing their representation. This time window, located early during the transformation, is a consequence of the memory’s structural configuration, where the activation diffusion across the network is maximized.
Impact of COVID-19 School Closures on White Matter Plasticity in the Reading Network
Authors: Blockmans Lauren , Hoeft Fumiko , Wouters Jan , Ghesquière Pol , Vandermosten Maaike 
Published: September 2024

Abstract
During the COVID-19 pandemic, children worldwide experienced school closures. Several studies have detected a negative impact on reading-related skills in children who experienced these closures during the early stages of reading instruction, but the impact on the reading network in the brain has not been investigated. In the current longitudinal study in a sample of 162 Dutch-speaking children, we found a short-term effect in the growth of phonological awareness in children with COVID-19 school closures compared to children without school closures, but no long-term effects one year later. Similarly, we did not find a long-term effect on the longitudinal development of white matter connectivity in tracts implicated during early reading development. Together, these findings indicate that one year after school closures no effects on the development of phonological awareness and white matter are found, yet it remains an open question whether short-term effects on the reading network could have been present and/or whether other networks (e.g., psychosocial related networks) are potentially more affected.
A Letter to the King
Authors: Torollo David 
Published: September 2024

Abstract
Many of the Jews who were expelled from Iberia in the fifteenth century settled in North Africa. More than 400 years later, Moroccan Sephardic Jews in Fes would engage with Spain again. In this article, I present an unpublished document of historical interest: a letter written in Judeo-Arabic in 1905 by the Jewish community of Fes and addressed to the Spanish king, Alfonso XIII, asking for financial support to build a Spanish school in the mellāḥ of the city. Sephardic Jews in the region had preserved Spanish traditions, claimed to be part of that culture, and, perhaps more importantly, demanded to be protected by it. I take this letter, whose edition, translation, and images are included, as a vantage point for exploring the linguistic, social, and political situation of Sephardic Jews in Fes at the turn of the last century.