bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of the effectiveness of hands-on versus online education in child passenger safety
Authors: Mantha Anita , Beckworth Kristen L , Ansiaux John A , Chen Carol C , Hoffman Benjamin , Shenoi Rohit P 
Published: August 2017

BackgroundCommunity paediatricians’ knowledge of appropriate child safety seat (CSS) use in vehicles may be inadequate. We compared the effectiveness of hands-on and online education in improving and retaining child passenger safety (CPS) knowledge and skills among paediatric trainees.MethodsPaediatric trainees were randomised to receive hands-on skills training versus a 1-hour online module in CPS. CSS knowledge and installation skills were assessed using a validated 10-item/point questionnaire and an assessment tool respectively at baseline and after 6 months. Preintervention and postintervention knowledge improvement and CSS installation skills between groups were assessed using paired t-tests and effect size (d).ResultsForty-eight students agreed to participate and were randomised. Thirty-nine completed training (hands-on: 23 and online: 15). At entry, no significant differences in learners’ demographics and prior CPS education existed. Baseline CPS knowledge scores did not differ significantly between groups (p=0.26). Postintervention, both groups demonstrated a significant increase in knowledge scores (hands-on=3.1 (95% CI 2.4 to 3.7), p<0.0001; online=2.6 (95% CI 1.9 to 3.3), p<0.0001), though the pre–post gain in knowledge scores were not significantly different between groups (p=0.35). At follow-up, both groups demonstrated a significant increase in knowledge scores (hands-on=1.8 (95% CI 1.2 to 2.4), p<0.0001; online=1.1 (95% CI 0.7 to 1.6), p<0.0001) with the hands-on group scores significantly better than the online group (p<0.02). The long-term gain in knowledge scores was not significantly different between groups (p=0.12).Baseline CSS installation skill scores did not significantly differ between groups for forward-facing seats (p=0.16) and rear-facing seats (p=0.51). At follow-up, mean CSS installation skill scores significantly increased for the hands-on group (forward-facing seat: 0.8 (95% CI 0.16 to 1.44), p<0.02; rear-facing seat: 1.2 (95% CI 0.6 to 1.7), p<0.001) but not for the online group (forward-facing seat: 0.9 (95% CI −0.08 to 1.9), p=0.07); rear-facing seat: −0.2 (95% CI −1.1 to 0.7), p=0.6).ConclusionsAmong paediatric trainees, hands-on and online CPS education are both effective in improving long-term CPS knowledge. Long-term installation skills for forward-facing and rear-facing CSS persist for hands-on education but are inconclusive for online education.
Verifying efficient function calls in CakeML
Authors: Owens Scott , Norrish Michael , Kumar Ramana , Myreen Magnus O. , Tan Yong Kiam 
Published: August 2017

We have designed an intermediate language (IL) for the CakeML compiler that supports the verified, efficient compilation of functions and calls. Verified compilation steps include batching of multiple curried arguments, detecting calls to statically known functions, and specialising calls to known functions with no free variables. Finally, we verify the translation to a lower-level IL that only supports closed, first-order functions.
These compilation steps resemble those found in other compilers (especially OCaml). Our contribution here is the design of the semantics of the IL, and the demonstration that our verification techniques over this semantics work well in practice at this scale. The entire development was carried out in the HOL4 theorem prover.
Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma
Authors: Zhou Feng , Shimoda Michiko , Olney Laura , Lyu Yuanzhi , Tran Khiem , Jiang Guochun , Nakano Kazushi , Davis Ryan R. , Tepper Clifford G. , Maverakis Emanual , Campbell Mel , Li Yuanpei , Dandekar Satya , Izumiya Yoshihiro 
Published: August 2017

AbstractPrimary effusion lymphoma (PEL) is an aggressive subtype of non-Hodgkin lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV) infection. Currently, treatment options for patients with PEL are limited. Oncolytic viruses have been engineered as anticancer agents and have recently shown increased therapeutic promise. Similarly, lytic activation of endogenous viruses from latently infected tumor cells can also be applied as a cancer therapy. In theory, such a therapeutic strategy would induce oncolysis by viral replication, while simultaneously stimulating an immune response to viral lytic cycle antigens. We examined the combination of the FDA-approved drug ingenol-3-angelate (PEP005) with epigenetic drugs as a rational therapeutic approach for KSHV-mediated malignancies. JQ1, a bromodomain and extra terminal (BET) protein inhibitor, in combination with PEP005, not only robustly induced KSHV lytic replication, but also inhibited IL6 production from PEL cells. Using the dosages of these agents that were found to be effective in reactivating HIV (as a means to clear latent virus with highly active antiretroviral therapy), we were able to inhibit PEL growth in vitro and delay tumor growth in a PEL xenograft tumor model. KSHV reactivation was mediated by activation of the NF-κB pathway by PEP005, which led to increased occupancy of RNA polymerase II onto the KSHV genome. RNA-sequencing analysis further revealed cellular targets of PEP005, JQ1, and the synergistic effects of both. Thus, combination of PEP005 with a BET inhibitor may be considered as a rational therapeutic approach for the treatment of PEL. Mol Cancer Ther; 16(11); 2627–38. ©2017 AACR.
Synthetic Lethality Interaction Between Aurora Kinases and CHEK1 Inhibitors in Ovarian Cancer
Authors: Alcaraz-Sanabria Ana , Nieto-Jiménez Cristina , Corrales-Sánchez Verónica , Serrano-Oviedo Leticia , Andrés-Pretel Fernando , Montero Juan Carlos , Burgos Miguel , Llopis Juan , Galán-Moya Eva María , Pandiella Atanasio , Ocaña Alberto 
Published: August 2017

Abstract
Ovarian cancer is characterized by frequent mutations at TP53. These tumors also harbor germline mutations at homologous recombination repair genes, so they rely on DNA-damage checkpoint proteins, like the checkpoint kinase 1 (CHEK1) to induce G2 arrest. In our study, by using an in silico approach, we identified a synthetic lethality interaction between CHEK1 and mitotic aurora kinase A (AURKA) inhibitors. Gene expression analyses were used for the identification of relevant biological functions. OVCAR3, OVCAR8, IGROV1, and SKOV3 were used for proliferation studies. Alisertib was tested as AURKA inhibitor and LY2603618 as CHEK1 inhibitor. Analyses of cell cycle and intracellular mediators were performed by flow cytometry and Western blot analysis. Impact on stem cell properties was evaluated by flow cytometry analysis of surface markers and sphere formation assays. Gene expression analyses followed by functional annotation identified a series of deregulated genes that belonged to cell cycle, including AURKA/B, TTK kinase, and CHEK1. AURKA and CHEK1 were amplified in 8.7% and 3.9% of ovarian cancers, respectively. AURKA and CHEK1 inhibitors showed a synergistic interaction in different cellular models. Combination of alisertib and LY2603618 triggered apoptosis, reduced the stem cell population, and increased the effect of taxanes and platinum compounds. Finally, expression of AURKA and CHEK1 was linked with detrimental outcome in patients. Our data describe a synthetic lethality interaction between CHEK1 and AURKA inhibitors with potential translation to the clinical setting. Mol Cancer Ther; 16(11); 2552–62. ©2017 AACR.
Caloric Restriction Prevents Carcinogen-Initiated Liver Tumorigenesis in Mice
Authors: Ploeger Jonathan M. , Manivel Juan C. , Boatner Lauren N. , Mashek Douglas G. 
Published: August 2017

Abstract
Caloric restriction (CR) and endurance exercise elicit wide-ranging health benefits including reduced risk of select cancers. In addition, diet composition influences oncogenesis, although its interactions with exercise and CR are not well understood. Therefore, to investigate the potential interactions between diet and lifestyle interventions on liver tumorigenesis, the carcinogen diethylnitrosamine was administered to 72 male C57Bl/6 mice that were subsequently fed diets enriched with lard (CTL) or olive oil and were further stratified to voluntary wheel running (Ex) or 30% CR for 49 weeks. Although Ex and diet composition did not influence liver oncogenesis, CR prevented hepatic tumor formation. In addition, CR reduced steatosis, hepatocyte ballooning, inflammation, and immune cell infiltration, all of which are hallmarks in the progression of nonalcoholic fatty liver disease to liver tumorigenesis. RNA sequencing of nontransformed liver tissues from CR mice revealed changes in metabolic pathways and reduced inflammation, cytokine production, stellate cell activation and migration, and genes associated with liver injury and oncogenesis. These data demonstrate that CR protects against steatosis, liver inflammation, and liver injury and is a robust deterrent of carcinogen-induced hepatic oncogenesis. Cancer Prev Res; 10(11); 660–70. ©2017 AACR.
Skill and Reliability of Seasonal Forecasts for the Chinese Energy Sector
Authors: Bett Philip E. , Thornton Hazel E. , Lockwood Julia F. , Scaife Adam A. , Golding Nicola , Hewitt Chris , Zhu Rong , Zhang Peiqun , Li Chaofan 
Published: August 2017

AbstractThe skill and reliability of forecasts of winter and summer temperature, wind speed, and irradiance over China are assessed using the Met Office Global Seasonal Forecast System, version 5 (GloSea5). Skill in such forecasts is important for the future development of seasonal climate services for the energy sector, allowing better estimates of forthcoming demand and renewable electricity supply. It was found that, although overall the skill from the direct model output is patchy, some high-skill regions of interest to the energy sector can be identified. In particular, winter mean wind speed is skillfully forecast around the coast of the South China Sea, related to skillful forecasts of the El Niño–Southern Oscillation. Such information could improve seasonal estimates of offshore wind-power generation. In a similar way, forecasts of winter irradiance have good skill in eastern central China, with possible use for solar-power estimation. Skill in predicting summer temperatures, which derives from an upward trend, is shown over much of China. The region around Beijing, however, retains this skill even when detrended. This temperature skill could be helpful in managing summer energy demand. While both the strengths and limitations of the results presented here will need to be considered when developing seasonal climate services in the future, the outlook for such service development in China is promising.
Statistics of Internal Tide Bores and Internal Solitary Waves Observed on the Inner Continental Shelf off Point Sal, California
Authors: Colosi John A. , Kumar Nirnimesh , Suanda Sutara H. , Freismuth Tucker M. , MacMahan Jamie H. 
Published: August 2017

AbstractMoored observations of temperature and current were collected on the inner continental shelf off Point Sal, California, between 9 June and 8 August 2015. The measurements consist of 10 moorings in total: 4 moorings each on the 50- and 30-m isobaths covering a 10-km along-shelf distance and an across-shelf section of moorings on the 50-, 40-, 30-, and 20-m isobaths covering a 5-km distance. Energetic, highly variable, and strongly dissipating transient wave events termed internal tide bores and internal solitary waves (ISWs) dominate the records. Simple models of the bore and ISW space–time behavior are implemented as a temperature match filter to detect events and estimate wave packet parameters as a function of time and mooring position. Wave-derived quantities include 1) group speed and direction; 2) time of arrival, time duration, vertical displacement amplitude, and waves per day; and 3) energy density, energy flux, and propagation loss. In total, over 1000 bore events and over 9000 ISW events were detected providing well-sampled statistical distributions. Statistics of the waves are rather insensitive to position along shelf but change markedly in the across-shelf direction. Two compelling results are 1) that the probability density functions for bore and ISW energy flux are nearly exponential, suggesting the importance of interference and 2) that wave propagation loss is proportional to energy flux, thus giving an exponential decay of energy flux toward shore with an e-folding scale of 2–2.4 km and average dissipation rates for bores and ISWs of 144 and 1.5 W m−1, respectively.
Involvement of palliative care in euthanasia practice in a context of legalized euthanasia: A population-based mortality follow-back study
Authors: Dierickx Sigrid , Deliens Luc , Cohen Joachim , Chambaere Kenneth 
Published: August 2017

Background: In the international debate about assisted dying, it is commonly stated that euthanasia is incompatible with palliative care. In Belgium, where euthanasia was legalized in 2002, the Federation for Palliative Care Flanders has endorsed the viewpoint that euthanasia can be embedded in palliative care. Aim: To examine the involvement of palliative care services in euthanasia practice in a context of legalized euthanasia. Design: Population-based mortality follow-back survey. Setting/participants: Physicians attending a random sample of 6871 deaths in Flanders, Belgium, in 2013. Results: People requesting euthanasia were more likely to have received palliative care (70.9%) than other people dying non-suddenly (45.2%) (odds ratio = 2.1 (95% confidence interval, 1.5–2.9)). The most frequently indicated reasons for non-referral to a palliative care service in those requesting euthanasia were that existing care already sufficiently addressed the patient’s palliative and supportive care needs (56.5%) and that the patient did not want to be referred (26.1%). The likelihood of a request being granted did not differ between cases with or without palliative care involvement. Palliative care professionals were involved in the decision-making process and/or performance of euthanasia in 59.8% of all euthanasia deaths; this involvement was higher in hospitals (76.0%) than at home (47.0%) or in nursing homes (49.5%). Conclusion: In Flanders, in a context of legalized euthanasia, euthanasia and palliative care do not seem to be contradictory practices. A substantial proportion of people who make a euthanasia request are seen by palliative care services, and for a majority of these, the request is granted.
Clinical description of attack-related cognitive symptoms in migraine: A systematic review
Authors: Gil-Gouveia Raquel , Martins Isabel Pavão 
Published: August 2017

Introduction Cognitive symptoms have been described during migraine attacks since the Roman era; while being neglected throughout the centuries, they are relevant contributors to migraine-related disability. Objective To determine whether cognitive symptoms are included in clinical series describing migraine attack phenomenology, and which symptoms occur in each attack phase. Method Systematic review of existing data on clinical descriptions of migraine attacks, focusing on cognitive symptomatology. Data were organized and analyzed qualitatively, due to methodological differences between studies. Results Twenty-four articles were reviewed, with a total sample of 7007 patients, including 82.9% females with an average age of 39.2 years. Twenty one (75%) studies analyzed one phase of the attack (eight prodromes, five auras, one between aura and pain, three headaches and three postdromes), the remaining studied more than one phase. Cognitive complaints were the most frequent symptom of the prodromic (30%) and headache (38%) phases, while fatigue (70%) dominated the resolution phase. Not enough data is available to estimate the frequency of cognitive symptoms during the aura. Discussion Cognitive symptoms are described in all phases of the migraine attack phenomenology in published clinical series of migraine. Their characteristics appear to be different in each attack phase, although methodological limitations prevent generalization of this finding.
Mobilization of Mechanically Ventilated Patients in Switzerland
Authors: Sibilla Alberto , Nydahl Peter , Greco Nicola , Mungo Giuseppe , Ott Natalie , Unger Ines , Rezek Spencer , Gemperle Sarah , Needham Dale M. , Kudchadkar Sapna R. 
Published: August 2017

Purpose: Growing evidence suggests that early mobilization benefits intensive care unit (ICU) patients. However, national practices and the culture of individual ICUs influence mobilization activities. Materials and Methods: In a 1-day, Swiss point prevalence study conducted in 35 ICUs (representing 45% of all ICUs), the highest level of mobilization for mechanically ventilated patients was characterized using the validated ICU Mobility Scale, along with data collection for potential safety events and mobilization barriers. Results: Among 161 mechanically ventilated patients, a total of 33% (n = 53) had active mobilization, with walking achieved by only 2% (n = 4). More severe organ failure was associated with lower mobilization (respiratory Sequential Organ Failure Assessment score: P = .037, cardiac: P = .008, neurology: P < .001). Barriers to mobilization were reported in 71% (n = 115), with deep sedation significantly higher among patients receiving passive versus active mobilization (14% vs 0%, P = .005). Potential safety events occurred in 20% (n = 33) of patients without significant differences between passive and active mobilization. Availability of physiotherapists and appropriate equipment were not reported barriers. Conclusion: Mobilization during mechanical ventilation occurred infrequently with greater organ failure associated with lower mobilization. Addressing the identified modifiable barriers via structured efforts to achieve multidisciplinary culture change is essential to decrease the common use of bed rest in Swiss ICUs.
Becoming a health literate organization: Formative research results from healthcare organizations providing care for undeserved communities
Authors: Adsul Prajakta , Wray Ricardo , Gautam Kanak , Jupka Keri , Weaver Nancy , Wilson Kristin 
Published: August 2017

Background Integrating health literacy into primary care institutional policy and practice is critical to effective, patient centered health care. While attributes of health literate organizations have been proposed, approaches for strengthening them in healthcare systems with limited resources have not been fully detailed. Methods We conducted key informant interviews with individuals from 11 low resourced health care organizations serving uninsured, underinsured, and government-insured patients across Missouri. The qualitative inquiry explored concepts of impetus to transform, leadership commitment, engaging staff, alignment to organization wide goals, and integration of health literacy with current practices. Findings Several health care organizations reported carrying out health literacy related activities including implementing patient portals, selecting easy to read patient materials, offering community education and outreach programs, and improving discharge and medication distribution processes. The need for change presented itself through data or anecdotal staff experience. For any change to be undertaken, administrators and medical directors had to be supportive; most often a champion facilitated these changes in the organization. Staff and providers were often resistant to change and worried they would be saddled with additional work. Lack of time and funding were the most common barriers reported for integration and sustainability. To overcome these barriers, managers supported changes by working one on one with staff, seeking external funding, utilizing existing resources, planning for stepwise implementation, including members from all staff levels and clear communication. Conclusion Even though barriers exist, resource scarce clinical settings can successfully plan, implement, and sustain organizational changes to support health literacy.
Hazard Identification and Risk Assessment for Improving Farm Safety on Canadian Farms
Authors: Chattha Hassan S. , Corscadden Kenneth W. , Zaman Qamar U. 
Published: August 2017

Abstract. Agriculture is one of the most hazardous industries worldwide. The number of serious accidents on farms, despite sophisticated technology, development of effective prevention methods, and high-quality training and improved skill levels of farmers, is still very high. The purpose of this study was to develop and apply a generic farm safety protocol to hazards that have been identified in previously published literature and demonstrate the potential benefits of such a protocol with a view to raising awareness of farm safety. Hazards in agriculture were categorized, and literature highlighting the risks associated with hazards was collated. A protocol was developed and applied to establish the likelihood of a hazard causing injury and the consequence of that injury should adverse effects of hazards be realized. The results indicated farm ownership, farm being used as a primary residence, and missing rollover protective structures as the greatest farm risks with expected likelihood and extreme consequence such as death or permanent disablement. Other hazards that require immediate attention while developing mitigation strategies include accident history and existing medical conditions of the farmer, working environment (i.e., alone and isolated), water bodies in the proximity of the farm, lack of periodic machine maintenance, uncovered power take-off and other rotating parts of the tractor, missing safety decals, auger entanglements, and unprotected use of pesticides. Intervention strategies may be guided by considering the results presented in this study. Moreover, farm safety specialists should increase their efforts to promote effective injury prevention methods and enforce safe work environments. The developed protocol addresses almost all common aspects of farming hazards and can be used to mitigate risks associated with hazards in any farm setting. Keywords: Agriculture, Farm safety, Generic protocol, Hazards, Likelihood.