bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Intramyocardial Adipose Tissue on the Accuracy of Endocardial Contact Mapping of the Chronic Myocardial Infarction Substrate
Authors: Samanta Rahul , Kumar Saurabh , Chik William , Qian Pierre , Barry Michael A. , Al Raisi Sara , Bhaskaran Abhishek , Farraha Melad , Nadri Fazlur , Kizana Eddy , Thiagalingam Aravinda , Kovoor Pramesh , Pouliopoulos Jim 
Published: October 2017

Background:
Recent studies have demonstrated that intramyocardial adipose tissue (IMAT) may contribute to ventricular electrophysiological remodeling in patients with chronic myocardial infarction. Using an ovine model of myocardial infarction, we aimed to determine the influence of IMAT on scar tissue identification during endocardial contact mapping and optimal voltage-based mapping criteria for defining IMAT dense regions.

Method and Results:

In 7 sheep, left ventricular endocardial and transmural mapping was performed 84 weeks (15–111 weeks) post-myocardial infarction. Spearman rank correlation coefficient was used to assess the relationship between endocardial contact electrogram amplitude and histological composition of myocardium. Receiver operator characteristic curves were used to derive optimal electrogram thresholds for IMAT delineation during endocardial mapping and to describe the use of endocardial mapping for delineation of IMAT dense regions within scar. Endocardial electrogram amplitude correlated significantly with IMAT (unipolar
r
=−0.48±0.12,
P
<0.001; bipolar
r
=−0.45±0.22,
P
=0.04) but not collagen (unipolar
r
=−0.36±0.24,
P
=0.13; bipolar
r
=−0.43±0.31,
P
=0.16). IMAT dense regions of myocardium reliably identified using endocardial mapping with thresholds of <3.7 and <0.6 mV, respectively, for unipolar, bipolar, and combined modalities (single modality area under the curve=0.80,
P
<0.001; combined modality area under the curve=0.84,
P
<0.001). Unipolar mapping using optimal thresholding remained significantly reliable (area under the curve=0.76,
P
<0.001) during mapping of IMAT, confined to putative scar border zones (bipolar amplitude, 0.5–1.5 mV).

Conclusions:
These novel findings enhance our understanding of the confounding influence of IMAT on endocardial scar mapping. Combined bipolar and unipolar voltage mapping using optimal thresholds may be useful for delineating IMAT dense regions of myocardium, in postinfarct cardiomyopathy.
Large Genomic Rearrangements of Desmosomal Genes in Italian Arrhythmogenic Cardiomyopathy Patients
Authors: Pilichou Kalliopi , Lazzarini Elisabetta , Rigato Ilaria , Celeghin Rudy , De Bortoli Marzia , Perazzolo Marra Marina , Cason Marco , Jongbloed Jan , Calore Martina , Rizzo Stefania , Regazzo Daniela , Poloni Giulia , Iliceto Sabino , Daliento Luciano , Delise Pietro , Corrado Domenico , Van Tintelen J. Peter , Thiene Gaetano , Rampazzo Alessandra , Basso Cristina , Bauce Barbara , Lorenzon Alessandra , Occhi Gianluca 
Published: October 2017

Background:
Arrhythmogenic cardiomyopathy (AC) is an inherited heart muscle disease associated with point mutations in genes encoding for cardiac desmosome proteins. Conventional mutation screening is positive in ≈50% of probands. Copy number variations (CNVs) have recently been linked to AC pointing to the need to determine the prevalence of CNVs in desmosomal genes and to evaluate disease penetrance by cosegregation analysis in family members.

Methods and Results:

A total of 160 AC genotype-negative probands for 5 AC desmosomal genes by conventional mutation screening underwent multiplex ligation-dependent probe amplification. Nine heterozygous CNVs were identified in 11 (6.9%) of the 160 probands. Five carried a deletion of the entire plakophilin-2 (
PKP2
) gene, 2 a deletion of only
PKP2
exon 4, 1 a deletion of the
PKP2
exons 6 to 11, 1 a
PKP2
duplication of 5′ untranslated region till exon 1, 1 the desmocollin-2 (
DSC2
) duplication of exons 7 to 9, and 1 a large deletion of chromosome 18 comprising both
DSC2
and
desmoglein-2
genes. All probands were affected by moderate-severe forms of the disease, whereas 10 (32%) of the 31 family members carrying one of these deletions fulfilled the diagnostic criteria.

Conclusions:
Genomic rearrangements were detected in ≈7% of AC probands negative for pathogenic point mutations in desmosomal genes, highlighting the potential of CNVs analysis to substantially increase the diagnostic yield of genetic testing. Genotype–phenotype correlation demonstrated the presence of the disease in about one third of family members carrying the CNV, underlying the role of other factors in the development and progression of the disease.
Mechanisms for the Maintenance of the Wintertime Basin-Scale Atmospheric Response to Decadal SST Variability in the North Pacific Subarctic Frontal Zone
Authors: Okajima Satoru , Nakamura Hisashi , Nishii Kazuaki , Miyasaka Takafumi , Kuwano-Yoshida Akira , Taguchi Bunmei , Mori Masato , Kosaka Yu 
Published: October 2017

Abstract
Mechanisms for the maintenance of a large-scale wintertime atmospheric response to warm sea surface temperature (SST) anomalies associated with decadal-scale poleward displacement of the North Pacific subarctic frontal zone (SAFZ) are investigated through the following two ensemble experiments with an atmospheric general circulation model (AGCM): one with climatological-mean SST and the other with positive SST anomalies along the SAFZ prescribed on top of the climatological-mean SST. As actually observed, the simulated January ensemble response over the North Pacific is anticyclonic throughout the depth of the troposphere, although its amplitude is smaller. This response is maintained through energy conversion from the ensemble climatological-mean circulation realized under the climatological SST as well as feedback from anomalous transient eddy activity, suggesting that the response may have characteristics as a preferred mode of variability (or “dynamical mode”). Conversions of both available potential energy and kinetic energy from the climatological-mean state are important for the observed anomaly, while the latter is less pronounced for the model response. Net transient feedback forcing is also important for both the observed anomaly and simulated response. These results imply that a moderate-resolution (~1°) AGCM may be able to simulate a basin-scale atmospheric response to the SAFZ SST anomaly through synoptic- and basin-scale dynamical processes. Weaker PNA-like internal variability in the model may lead to the weaker response, suggesting that misrepresentation of intrinsic atmospheric variability can affect the model response to the SST anomaly.
Toward a Polarimetric Radar Classification Scheme for Coalescence-Dominant Precipitation: Application to Complex Terrain
Authors: Porcacchia Leonardo , Kirstetter P. E. , Gourley J. J. , Maggioni V. , Cheong B. L. , Anagnostou M. N. 
Published: October 2017

Abstract
Accurate quantitative precipitation estimation over mountainous basins is of great importance because of their susceptibility to natural hazards. It is generally difficult to obtain reliable precipitation information over complex areas because of the scarce coverage of ground observations, the limited coverage from operational radar networks, and the high elevation of the study sites. Warm-rain processes have been observed in several flash flood events in complex terrain regions. While they lead to high rainfall rates from precipitation growth due to collision–coalescence of droplets in the cloud liquid layer, their characteristics are often difficult to identify. X-band mobile dual-polarization radars located in complex terrain areas provide fundamental information at high-resolution and at low atmospheric levels. This study analyzes a dataset collected in North Carolina during the 2014 Integrated Precipitation and Hydrology Experiment (IPHEx) field campaign over a mountainous basin where the NOAA/National Severe Storm Laboratory’s X-band polarimetric radar (NOXP) was deployed. Polarimetric variables are used to isolate collision–coalescence microphysical processes. This work lays the basis for classification algorithms able to identify coalescence-dominant precipitation by merging the information coming from polarimetric radar measurements. The sensitivity of the proposed classification scheme is tested with different rainfall-rate retrieval algorithms and compared to rain gauge observations. Results show the inadequacy of rainfall estimates when coalescence identification is not taken into account. This work highlights the necessity of a correct classification of collision–coalescence processes, which can lead to improvements in quantitative precipitation estimation. Future studies will aim at generalizing this scheme by making use of spaceborne radar data.
Combined transarterial chemoembolization and radiofrequency ablation for small treatment-naïve hepatocellular carcinoma infeasible for ultrasound-guided radiofrequency ablation: long-term outcomes
Authors: Hyun Dongho , Cho Sung Ki , Shin Sung Wook , Park Kwang Bo , Lee Sang Yub , Park Hong Suk , Do Young Soo 
Published: October 2017

Background Ultrasound (US)-guided radiofrequency ablation (RFA) for small hepatocellular carcinoma (HCC) is often infeasible due to unfavorable location and poor conspicuity. Those small HCCs can be treated with combined transarterial chemoembolization (TACE) and RFA. Purpose To evaluate long-term outcomes of combined TACE and RFA for small treatment-naïve HCC infeasible for US-guided RFA. Material and Methods Between February 2009 and January 2014, 69 patients with small (≤3 cm) HCC infeasible for US-guided RFA received TACE and subsequent RFA in one session as a first-line treatment. Local tumor progression (LTP), overall survival (OS), and event-free survival rates were evaluated. Univariate and multivariate analyses were conducted to identify prognostic factors. Results Cumulative rates of LTP were 4.4%, 6.8%, 8.2%, 9.5%, and 9.5% at one, two, three, five, and seven years, respectively. Cumulative one-, two-, three-, five-, and seven-year OS rates were 100%, 95%, 89%, 80%, and 80%, respectively. Cumulative one-, two-, three-, five-, and seven-year event-free survival rates were 81%, 63%, 54%, 31%, and 20%, respectively. No significant prognostic factors for LTP, OS, and event-free survival were identified in univariate analysis. Conclusion Combined TACE and RFA appears to be an effective treatment for small treatment-naïve HCC infeasible for US-guided RFA in terms of LTP and OS.
Point-of-Care Testing in Community Pharmacies: Keys to Success From Pennsylvania Pharmacists
Authors: Steltenpohl Emily A. , Barry Brandon K. , Coley Kim C. , McGivney Melissa S. , Olenak Julie L. , Berenbrok Lucas A. 
Published: October 2017

Background Clinical Laboratory Improvement Amendments (CLIA)-waived tests allow for quick, accurate, and noninvasive laboratory testing. Community pharmacists utilize CLIA-waived tests to provide clinical services such as point-of-care (POC) testing to help manage chronic disease and acute illness. Objective To identify key themes in the successful delivery of POC testing services by community pharmacists in Pennsylvania. Results An initial search identified 51 Pennsylvania pharmacies with a CLIA waiver. Of these, five independent pharmacies met inclusion criteria, three of which completed interviews. The remaining 38 chain pharmacies were represented by three interviews. In total, five key themes were identified as essential to POC testing services: (1) utilize state resources and professional connections to navigate federal and state regulations, (2) establish relationships with physician partners (3) offer tests that are meaningful to patients and their physicians, (4) evaluate financial impact, workflow adaptations, and marketing approaches when implementing POC testing services, and (5) focus on individualized attention and convenience of community pharmacy-based POC testing to improve patient satisfaction. Conclusion Successful POC testing services in community pharmacy practice rely on utilizing resources, partnering with known physicians, selecting meaningful tests for patients, and analyzing finances, workflow, and marketing to provide individualized attention and convenient care.
Single-Surgeon Experience and Complications of a Fixed-Bearing Total Ankle Arthroplasty
Authors: Pangrazzi Garett J. , Baker Erin A. , Shaheen Phillip J. , Okeagu Chikezie N. , Fortin Paul T. 
Published: October 2017

Background: Total ankle arthroplasty (TAA) has historically resulted in inferior survivorship rates compared with total hip and knee arthroplasty, because of technical issues unique to ankle anatomy. In this study, a single-surgeon series of intra- and postoperative complications as well as resultant reoperations/revisions of the Tornier Salto Talaris, a fixed-bearing TAA prosthesis, were reviewed. Methods: Medical records from index procedure to latest follow-up of primary TAA were reviewed. Complications were categorized according to the Glazebrook classification; additional complications were documented. Concurrent procedures were recorded, and radiographs were analyzed for alignment, subsidence, and cyst formation. Time to complication onset and learning curve analyses were performed. One hundred four Salto Talaris TAA prostheses (96 patients), with an average follow-up of 46 months, were included. Results: Thirty-five complications were identified in 32 ankles with a 34% complication rate, resulting in 11 reoperations (5 TAA revisions). Technical error (n = 12), wound healing (n = 9), and aseptic loosening (n = 4) were the most common complications, and there were no statistically significant differences in demographics or follow-up duration between cases with versus without complications. In both the cohorts with and without complications, there were moderate, negative correlations between radiographically observed keel osteopenia and lucency (ρ = −0.548, P = .00125, and ρ = −0.416, P = .000303, respectively); also, in the complication cohort, a weak, positive correlation between subsidence and lucency (ρ = 0.357, P = .0450) was found. Conclusion: Salto Talaris TAA survivorship and reoperation rates in our series were comparable with previous reports, using either the same or similar mobile-bearing prostheses; new information regarding complication, radiographic, and learning curve analyses was presented. Level of Evidence: Level IV, retrospective case series.
Multiplicity-adjusted semiparametric benefiting subgroup identification in clinical trials
Authors: Schnell Patrick M , Müller Peter , Tang Qi , Carlin Bradley P 
Published: October 2017

Background A recent focus in the health sciences has been the development of personalized medicine, which includes determining the population for which a given treatment is effective. Due to limited data, identifying the true benefiting population is a challenging task. To tackle this difficulty, the credible subgroups approach provides a pair of bounding subgroups for the true benefiting subgroup, constructed so that one is contained by the benefiting subgroup while the other contains the benefiting subgroup with high probability. However, the method has so far only been developed for parametric linear models. Methods In this article, we develop the details required to follow the credible subgroups approach in more realistic settings by considering nonlinear and semiparametric regression models, supported for regulatory science by conditional power simulations. We also present an improved multiple testing approach using a step-down procedure. We evaluate our approach via simulations and apply it to data from four trials of Alzheimer’s disease treatments carried out by AbbVie. Results Semiparametric modeling yields credible subgroups that are more robust to violations of linear treatment effect assumptions, and careful choice of the population of interest as well as the step-down multiple testing procedure result in a higher rate of detection of benefiting types of patients. The approach allows us to identify types of patients that benefit from treatment in the Alzheimer’s disease trials. Conclusion Attempts to identify benefiting subgroups of patients in clinical trials are often met with skepticism due to a lack of multiplicity control and unrealistically restrictive assumptions. Our proposed approach merges two techniques, credible subgroups, and semiparametric regression, which avoids these problems and makes benefiting subgroup identification practical and reliable.
Inpatient Massage Therapy Versus Music Therapy Versus Usual Care: A Mixed-methods Feasibility Randomized Controlled Trial
Authors: Roseen Eric J , Cornelio-Flores Oscar , Lemaster Chelsey , Hernandez Maria , Fong Calvin , Resnick Kirsten , Wardle Jon , Hanser Suzanne , Saper Robert 
Published: October 2017

Background Little is known about the feasibility of providing massage or music therapy to medical inpatients at urban safety-net hospitals or the impact these treatments may have on patient experience. Objective To determine the feasibility of providing massage and music therapy to medical inpatients and to assess the impact of these interventions on patient experience. Design Single-center 3-arm feasibility randomized controlled trial. Setting Urban academic safety-net hospital. Patients Adult inpatients on the Family Medicine ward. Interventions Massage therapy consisted of a standardized protocol adapted from a previous perioperative study. Music therapy involved a preference assessment, personalized compact disc, music-facilitated coping, singing/playing music, and/or songwriting. Credentialed therapists provided the interventions. Measurements Patient experience was measured with the Hospital Consumer Assessment of Healthcare Providers and Systems (HCAHPS) within 7 days of discharge. We compared the proportion of patients in each study arm reporting “top box” scores for the following a priori HCAHPS domains: pain management, recommendation of hospital, and overall hospital rating. Responses to additional open-ended postdischarge questions were transcribed, coded independently, and analyzed for common themes. Results From July to December 2014, 90 medical inpatients were enrolled; postdischarge data were collected on 68 (76%) medical inpatients. Participants were 70% females, 43% non-Hispanic black, and 23% Hispanic. No differences between groups were observed on HCAHPS. The qualitative analysis found that massage and music therapy were associated with improved overall hospital experience, pain management, and connectedness to the massage or music therapist. Conclusions Providing music and massage therapy in an urban safety-net inpatient setting was feasible. There was no quantitative impact on HCAHPS. Qualitative findings suggest benefits related to an improved hospital experience, pain management, and connectedness to the massage or music therapist.
Development of Solid Catalyst–Solid Substrate Reactions for Efficient Utilization of Biomass
Authors: Kobayashi Hirokazu , Fukuoka Atsushi 
Published: October 2017

Abstract
The efficient catalytic conversion of lignocellulose is a formidable issue, but it is worth studying in terms of the high potential as renewable chemical feedstock. In this account, we describe our approach to convert solid cellulose with solid catalysts. We found that carbons bearing weak acid sites were active for the hydrolysis of cellulose. The catalyst produced glucose in up to 88% yield after the formation of good solid–solid contact, due to selective enhancement of the solid–solid interfacial reaction. We also developed a cyclic system to efficiently convert real lignocellulosic biomass. Mechanistic study has revealed that polycyclic carbon aromatics attract cellulose by CH–π interactions mainly consisting of dispersion forces and hydrophobic interactions. The adsorbed cellulose molecules diffuse on the surface, rapidly penetrate even micropores, and undergo hydrolysis by weak acid sites such as carboxylic acids. Phenolic or carboxylic groups adjacent to the weak acid increase the frequency factor by forming hydrogen bonds. The combined functions of carbon derived from both polar and non-polar groups achieve the hydrolysis of cellulose. Finally, we comment on future perspective to apply these findings.
Molecular Transformations Using Bis(iodozincio)methane–The Role of Chelation in Main Group Organometallic Chemistry
Authors: Matsubara Seijiro 
Published: October 2017

Abstract
The stereoselectivity for the addition of an organometallic reagent to an aldehyde or ketone possessing a Lewis basic atom at the α-position can be predicted according to the well-known Chelation Model. Herein we discuss stereoselective reactions of bis(iodozincio)methane, which can coordinate to a heteroatom containing substrate with two zinc atoms in the reagent. Zinc atom coordination in a face-to-face manner to the substrates containing two heteroatoms enables specific molecular recognition, realizing novel molecular transformations.
Enhanced Quantum Yield of Fluorophores in Confined Spaces of Supermicroporous Silicas
Authors: Ogawa Shumpei , Wakayama Takuya , Watanabe Hiroto , Hayashi Kosei , Ogata Shuhei , Oaki Yuya , Hasegawa Miki , Imai Hiroaki 
Published: October 2017

Abstract
The optical properties of polycyclic aromatic hydrocarbon fluorophores, such as pyrene and perylene, are controlled by confined spaces of meso- and supermicropores in a silica matrix. The quantum yield of fluorescence from monodispersed pyrene and perylene increases with limitation of the excimer formation in 1 nm supermicropores. When the pore diameter is close to the molecular size, solid-state fluorescence having a high quantum yield is achieved via the fluorophores in the confined spaces by suppressing the aggregation, the interaction with charge-transfer sites and the stabilization of the excited state.
Role of 18F-FDG PET/CT vs CT-scan in patients with pulmonary metastases previously operated on for colorectal liver metastases
Authors: Lopez-Lopez Victor , Robles Ricardo , Brusadin Roberto , López Conesa Asuncion , Torres Juan , Perez Flores Domingo , Navarro Jose Luis , Gil Pedro Jose , Parrilla Pascual 
Published: October 2017

Objective:
There is currently no conclusive scientific evidence available regarding the role of the 18F-FDG PET/CT for detecting pulmonary metastases from colorectal cancer (PMCRC) in patients operated on for colorectal liver metastases (CRLM). In the follow up of patients who underwent surgery for CRLM, we compare CT-scan and 18F-FDG PET/CT in patients with PMCRC.

Methods:
We designed the study prospectively performing an 18F-FDG PET/CT on all patients operated on for CRLM where the CT-scan detected PMCRC during the follow up. We included patients who were operated on for PMCRC because the histological findings were taken as a control rather than biopsies.

Results:
Of the 101 pulmonary nodules removed from 57 patients, the CT-scan identified a greater number (89 nodules) than the 18F-FDG PET/CT (75 nodules) (p &lt; 0.001). Sensitivity was greater with the CT-scan (90 vs 76%, respectively) with a lower specificity (50 vs 75%, respectively) than with the 18F-FDG PET/CT. There were no differences between positive-predictive value and negative-predictive value. The 18F-FDG PET/CT detected more pulmonary nodules in four patients (one PMCRC in each of these patients) and more extrapulmonary disease in six patients (four mediastinal lymph nodes, one retroperitoneal lymph node and one liver metastases) that the CT-scan had not detected.

Conclusion:
Although CT-scans have a greater capacity to detect PMCRC, the 18F-FDG PET/CT could be useful in the detection of more pulmonary and extrapulmonary disease not identified by the CT-scan.

Advances in knowledge:
We tried to clarify the utility of 18F-FDG PET/CT in the management of this subpopulation of patients.