bluuebunny/crossref_metadata_2025_split huggingface dataset:
Context-dependent deposition and regulation of mRNAs in P-bodies
Authors: Wang Congwei , Schmich Fabian , Weidner Julie , Beerenwinkel Niko , Spang Anne 
Published: July 2017

AbstractCells respond to stress by remodeling their transcriptome through transcription and degradation. Xrn1p-dependent degradation in P-bodies is the most prevalent pathway. Yet, P-bodies may facilitate not only decay but also act as storage compartment. However, which and how mRNAs are selected into different degradation pathways and what determines the fate of any given mRNA in P-bodies remain largely unknown. We devised a new method to identify both common and stress-specific mRNA subsets associated with P-bodies. mRNAs targeted for degradation to P-bodies, decayed with different kinetics. Moreover, the localization of a specific set of mRNAs to P-bodies under glucose deprivation was obligatory to prevent decay. Depending on its client mRNA, the RNA binding protein Puf5p either promoted or inhibited decay. The Puf5p-dependent storage of a subset of mRNAs in P-bodies under glucose starvation may be beneficial with respect to chronological lifespan.
RXFP1 expression is regulated by miR-144-3p in Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis
Authors: Bahudhanapati Harinath , Tan Jiangning , Dutta Justin A , Strock Stephen B , Zhang Yingze , Kass Daniel J 
Published: July 2017

ABSTRACTRelaxin has been considered as a potential therapy for patients with pulmonary fibrosis. We have previously shown, however, that a potential limitation of relaxin-based therapy for Idiopathic Pulmonary Fibrosis (IPF) is the loss of expression of the relaxin receptor Relaxin/Insulin Like Receptor 1 (RXFP1) expression in fibroblasts. The molecular mechanism for RXFP1 down-regulation in IPF patients remains unclear. To determine whether microRNAs play a role in RXFP1 gene expression, we employed a bioinformatics approach to identify microRNAs (miRs) that are predicted to target RXFP1. Byin silicoanalysis, we identified a putative target site in the RXFP1 mRNA for the miR-144 family. We found that miR-144-3p was upregulated in IPF fibroblasts compared to donor lung fibroblast controls. Forced miR-144-3p mimic expression reduced RXFP1 mRNA and protein levels and increased expression of the myofibroblast marker alpha-smooth muscle actin (α-SMA) in donor lung fibroblasts. IPF lung fibroblasts transfected with a miR-144-3p inhibitor increased RXFP1 expression and reduced α-SMA expression. A lentiviral luciferase reporter vector carrying the WT 3’UTR of RXFP1 was repressed more in lung fibroblasts whereas vector carrying a mutated miR-144-3p binding site exhibited less sensitivity to endogenous miR-144-3p expression, suggesting that RXFP1 is a direct target of miR-144-3p. Thus, miR-144-3p is highly expressed in IPF fibroblasts and acts as a negative regulator of RXFP1 protein expression.
Zinc storage granules in the Malpighian tubules ofDrosophila melanogaster
Authors: Tejeda-Guzmán Carlos , Rosas-Arellano Abraham , Kroll Thomas , Webb Samuel M. , Barajas-Aceves Martha , Osorio Beatriz , Missirlis Fanis 
Published: July 2017

ABSTRACTMembrane transporters and sequestration mechanisms concentrate metal ions differentially into discrete subcellular microenvironments for usage in protein cofactors, signaling, storage, or excretion. Here we identify zinc storage granules as the insect’s major zinc reservoir in primary Malpighian tubule epithelial cells ofDrosophila melanogaster. The concerted action of Adaptor Protein-3, Rab32, HOPS and BLOC complexes as well as of the white-scarlet (ABCG2-like) and ZnT35C transporters is required for zinc storage granule biogenesis. Due to similar lysosome related organelle defects, patients with Hermansky-Pudlak syndrome may lack zinc granules in beta pancreatic cells, intestinal paneth cells and presynaptic vesicles of hippocampal mossy fibers.
Subject or object: a product’s scent congruent perspectives
Authors: Arboleda Ana M. , Arce-Lopera Carlos , González Samuel 
Published: July 2017

PurposeThe purpose of this paper is evaluate to what extent consumers can recognise a scent within a context that is congruent either with the product or with the user, respectively, objects’ quality or subjects’ involvement.Design/methodology/approachThis paper consists of two experimental studies. The first study assesses people’s capacity to recognise three scents: leather, synthetic leather, and fabric. The second study assesses the way in which a frame of reference (quality or involvement) affects people’s capacity for scent recognition (leather and fabric).FindingsResults confirm the difficulty of scent recognition revealing, in the first study, a low level of consistency in subjects’ responses. The second study shows an interaction between the type of scent and consumers’ framework: subjects who are primed to think about product quality present more accurate scent recognition when they smell leather, whereas subjects who are primed to think about themselves present more accurate scent recognition when they smell fabric.Practical implicationsThese results can be used in brand communication. A scent, such as that of leather, should highlight quality attributes in its communication. If the product is unscented, communication should highlight the subject who uses the product.Originality/valuePrevious studies show the importance of the consistency between scent and product marketing strategies. This study complements these findings by differentiating the context where a scent is presented considering either the product (the object’s quality attributes) or the individual who uses that product (subject’s involvement).
Dynamic capabilities and marketing capabilities in Portugal
Authors: Dias Álvaro , Renato Pereira 
Published: July 2017

Purpose
The purpose of this paper is to offer an operationalization of an aggregate construct and a decisive contribution to building a dynamic capabilities theory with marketing implications. The authors investigate the influence of dynamic capabilities, specifically routine creation through embedding learning and knowledge, on marketing capabilities and performance in Portugal. The authors examine the direct relationship between dynamic capabilities and marketing capabilities, which is indirectly linked to performance depending on the effectiveness of the resulting new resource configuration.

Design/methodology/approach
The authors used four construct dimensions: knowledge creation routines, knowledge transfer processes, marketing capabilities, and firm performance. The study was based on an inter-industry random sample of firms selected from a commercial list. During a nine-month period the authors gathered data from a questionnaire delivered in hand to participating firms and collected through in-depth personal interviews. It was filled out by directors of Portuguese firms who agreed to participate in this study.

Findings
First, dynamic capabilities play an important role in the evolution of marketing capabilities and the maintenance of competitive advantage. Specifically, the authors identified a link between knowledge creation routines and knowledge transfer processes with marketing capabilities.
Second, the effect of dynamic capabilities on performance can be considered to be substantially indirect. However, the results also show a direct link between knowledge transfer and performance.

Originality/value
First, the development of a model establishing the contribution to the evolution of marketing capabilities in order to compete in a changing environment, considering the critical effect of knowledge creation and transfer in a non-static market configuration.
Second, the analysis of marketing capabilities from different layers, from strategic to more operational aspects.
Can e-learning improve job security? Evidence from 28 European countries
Authors: Martínez-Cerdá Juan-Francisco , Torrent-Sellens Joan , González-González Inés 
Published: July 2017

PurposeThe purpose of this paper is to prove that e-learning, in union with another variable, builds a statistically significant relationship for estimating improvements in employment security, i.e., transition to employment of the same or higher job security as the previous year.Design/methodology/approachUsing data from Eurostat 2007-2013 in 28 European countries, and after carrying out analysis of 261 regression models between the e-learning variable, along with another variable related to working conditions, education, or e-skills levels of citizens.FindingsThis study provides evidence about: there is a statistically significant relationship (p-value<0.05) between employment security (dependent variable), e-learning and another variable (independent variables) in 60.7 percent of 28 European countries analyzed (p-value<0.05 for at least one of these two independent variables); and there is a statistically significant relationship (p-value<0.05) in 75 percent of 28 countries (p-value<0.1 for at least one of these two independent variables). Consequently, a set with the minimum number of useful indicators for calculating the employment security is proposed: e-learning, labor transition, tertiary education, temporary employees, e-job search and e-skills.Practical implicationsMoreover, several similarities between studied countries are found, helping to formulate various recommendations based on complementarities between being an employee and using lifelong e-learning systems as a way for improving employment security.Originality/valueThis is one of the first studies to provide evidence of the relationship between e-learning and job security in Europe, in view of this, it should be considered as a key element and essential to any European policy related to work.
Is emotional intelligence the panacea for a better job performance? A study on low-skilled back office jobs
Authors: Sastre Castillo Miguel Ángel , Danvila Del Valle Ignacio 
Published: July 2017

PurposeThe purpose of this paper is to investigate the relationship between emotional intelligence (EI), organizational affective commitment (AC), and performance at low-skilled back office positions.Design/methodology/approachIn all, 397 participants in low-skilled back office positions from a service company completed a questionnaire assessing EI, AC, and performance. The authors used multiple regression models for testing whether higher levels of EI and AC predicted better performance. Additionally, they tested to see whether EI and AC were positively related.FindingsThe results showed that workers in low-skilled back office positions with higher EI and AC had better performance. In this sense, intrapersonal skills and mood management were the dimensions of EI with the highest predictive power. Also, EI and AC were positively related, with intrapersonal skills and adaptability being the dimensions of EI most closely associated with AC. Finally, the predictive power on performance was increased when EI and AC were considered simultaneously.Originality/valueTraditionally, the involvement of EI and other personal dimensions in increasing organizational commitment and better work performance has been studied in high-skilled and executive positions, as well as in front office low-skilled positions. However, there is little empirical evidence regarding the simultaneous influence of EI and AC on performance in low-skilled back office positions. This gap prompted this research, which suggests that the investment of organizational resources is mandatory for improving EI and, hence, organizational commitment and work performance in these employees.
The HRM-performance relationship revisited
Authors: Salas-Vallina Andres , Fernandez Rafael 
Published: July 2017

Purpose
The purpose of this paper is to investigate the relationship between inspirational leadership, participative decision making (PDM) and happiness at work (HAW).

Design/methodology/approach
The sampling frame consists of medical specialists in allergy of Spanish public hospitals (n=167). The authors used structural equation modelling to verify if the relationship between inspirational leadership and HAW is mediated by PDM.

Findings
Results suggest that PDM fully mediates the relationship between inspirational leadership and HAW. Thus, PDM plays an essential role in explaining how inspirational leader behaviours.

Research limitations/implications
The authors put forward a cross-sectional research, which does not guarantee similar results in the future. Future longitudinal studies may reveal further effects of inspirational motivation and PDM beyond HAW. Also the authors focussed on a specific population of medical specialists working in public allergy units. Future research might consider longitudinal analysis and other populations.

Practical implications
This research provides evidence of the direct and positive effect of inspirational leadership on HAW. However, fostering inspirational leadership is not sufficient on its own to foment HAW, and should be complemented by applying other organisational factors such as PDM.

Originality/value
In recent years, some studies have put forward different conceptual models to explain the gap in the relationship between human resource management and performance, considering the effect of mediating variables. This study proposes a theoretical model that attempts to develop this human resource “black box” by empirically validating a conceptual proposal that links inspirational leadership, PDM and HAW.
Modelling energy consumption behaviour using “energy culture” concept for student accommodations in Malaysian public universities
Authors: Ishak Mohd Hafizal 
Published: July 2017

Purpose
In working towards a sustainable campus of public universities, energy consumption behaviour assessment is one of the several issues that requires attention by the facilities manager. Information on energy consumption behaviour is needed to determine potential energy savings. The purpose of this study is to assess energy consumption behaviour for student accommodations in Malaysian public universities.

Design/methodology/approach
This study focuses on developing energy consumption behaviour models (ECBMs) and assesses the potential energy savings. The “energy culture” framework consolidated with multiple regression analysis is used to strengthen the development of ECBMs. A self-administrated survey involving 1,009 respondents in selected public universities was carried out.

Findings
The result shows that five factors from the energy culture framework contribute to energy consumption behaviour, namely, building regulation, environmental concern, education, social marketing and direct factors (device and activities). These factors are included in the model for predicting energy consumption levels. The results show that there is a 78 per cent difference in energy consumption between the observed and predicted data.

Practical implications
This study indicates a high potential energy saving among students of Malaysian public universities.

Originality/value
The model was tested against the overall students among Malaysian public universities. In future, the model can be tested within hostel accommodations. The present assessment revealed the potential energy saving among the hostel buildings and sets the target regarding which building has a potential to reduce energy. It also helps the facilities managers to come up with strategies for programmes and energy policy in public universities.
Travel modes in grocery shopping
Authors: Hagberg Johan , Holmberg Ulrika 
Published: July 2017

Purpose
Although the movement of goods by consumers represents a large proportion of the economic and environmental impact of the distribution chain, this topic has been insufficiently explored in the retailing literature. The purpose of this paper is to contribute to the understanding of shopping travel-mode choice in the context of grocery shopping.

Design/methodology/approach
The paper presents findings from a Swedish national survey of 1,694 respondents that included questions regarding travel-mode choices and consumer characteristics, mobility conditions, shopping behaviours and environmental interests and engagements.

Findings
This paper shows how travel modes interrelate and how various consumer characteristics, shopping behaviours, mobility conditions and environmental interests and engagements relate to and affect travel-mode choice in grocery shopping. General travel patterns and distance to store are shown to be the most important factors in explaining the mode of transport for grocery shopping.

Originality/value
This paper presents data from a national representative survey and provides novel analyses of travel-mode choices in grocery shopping and the interrelationships among those choices, in addition to the interrelationship between travel-mode choice and the use of home delivery. This paper contributes to a further understanding of consumer mobility in the context of grocery shopping.
Mavens’ price and non-price on-pack extrinsic cue search behaviours
Authors: Collins Alan M. , George Richard G. 
Published: July 2017

Purpose
The purpose of this paper is to investigate whether or not mavens’ dissemination activities are likely to promote or hinder retailers’ store brand premiumisation attempts, by revealing the relationship between mavens’ price and non-price on-pack extrinsic cue search and their store brand purchasing behaviours.

Design/methodology/approach
The paper adopts a hypothetic-deductive approach and develops a model of mavens’ store brand purchasing behaviour. The model is tested using SEM on a US data set containing 457 respondents. A full discussion of the direct, indirect and total effects is provided.

Findings
Mavens’ store brand purchasing behaviours are strongly linked to their price search activities and negatively related to their use of non-price on-pack extrinsic cues. This indicates that their dissemination activities are likely to stress lower prices and hence price competition rather than promote other cues used to infer quality. Thus, mavens are likely to inhibit retailers’ store brand premiumisation attempts. Mavens’ investments in time engaged in search activities are strongly linked to social returns rather than private financial savings.

Research limitations/implications
The work is based on data collected using an online survey in one region of the USA where store brands are not as prevalent in other countries such as the UK.

Practical implications
The investigation of non-price on-pack extrinsic cues reduces mavens’ store brand purchasing behaviours while the use of price cues increases them. This suggests that even with mavens’ market expertise that a non-price extrinsic cue deficit continues to exist for these products. Consequently, retailers need to re-examine and rework the cues contained on pack to convey more positive consumption-related information if mavens are to become store brand advocates.

Originality/value
Rather than conceptualising the maven as possessing market wide knowledge, this research adopts a domain specific perspective arguing that price mavenism can be distinguished from product-related mavenism with consequences for the set of extrinsic cues used as part of the maven’s search process. In doing so, it reveals the conflicting effects that these maven dimensions have on purchasing behaviours and the likely effects on mavens’ dissemination activities.
No more blaming the weather: a retailer’s approach to measuring and managing weather variability
Authors: Bertrand Jean-Louis , Parnaudeau Miia 
Published: July 2017

PurposeRetailers have long been aware that weather affects the sales of a myriad of products, but until now, most were not in a position to manage the risks weather presents. Rising weather variability combined with advances in weather-index financial instruments have prompted new interest in investigating the relationship between sales and weather. The purpose of this paper is to explore the impact of changes in weather on UK retail sales, to estimate the contribution of weather to sales, and evaluate the maximum potential loss caused by adverse weather, for each season and retail sector.Design/methodology/approachThe authors present a methodology to identify and quantify the extent to which a company is exposed to weather risks, in order to incorporate them into its risk management policy and take actions to mitigate these risks. For each season and each retail category, the authors provide a measure of the impact of weather on sales that can be used as a benchmark to analyse sales performance.FindingsThe authors propose a new risk assessment indicator to evaluate the potential losses caused by adverse weather (WeatherRisk). The authors show that intra-annual changes in weather significantly affect retail sales. The exposure of retail categories to weather are not the same depending on the season, and the response of individual retail categories to the same change in weather varies considerably. Although temperature is a predominant explanatory variable, the authors show that weather-sensitivity analysis should include precipitation, humidity rate and wind.Research limitations/implicationsOne limitation of this study is that the authors individually compute WeatherRisk for each significant weather variable. Further research could explore new approaches to evaluate Total WeatherRisk, which take into account potential multicollinearity issues between weather variables.Practical implicationsThe methodology allows retailers to measure the effects of weather on sales performance, evaluate the risks at stake, and protect sales and margins from weather risks, with newly available index-based financial instruments. Managers may now actively use weather as a differential advantage, and at the same time focus their efforts on improving resiliency to increasing climate variability.Originality/valueIn this paper, the authors produce a detailed analysis of the exposure of each retail sectors to unseasonal weather. This is the first time all retail sectors are analysed and ranked per season at a national level. The authors provide managers with actionable information to improve their understanding of how weather impact sales over each season, and to allow them to structure weather-index-based instruments with financial partners.
When location and content matter: effects of mobile messages on intention to redeem
Authors: Beeck Ines , Toporowski Waldemar 
Published: July 2017

Purpose
The purpose of this paper is to examine the effect of mobile messages on intention to redeem a coupon or promotional offer, depending on location and content. Location (home, city, shop) and content (coupon, promotional message) were used as independent factors.

Design/methodology/approach
Participants in two online surveys (using 3×3 and 3×2 between-subjects factorial designs) received both simulated and real application smartphone messages and they got the location where the smartphone shopping message scenario is located. The surveys produced 528 responses for analysis in the first study and 146 answers for the second study.

Findings
The results indicate that mobile messages can be highly effective for users of discount apps when the consumer is near the shop. However, the high perceived risk associated with such a message could deter potential customers from using mobile coupons.

Research limitations/implications
The main limitation of this study is that few consumers used the discount mobile applications examined. Future research should implement field experiments with real and potential users to investigate this low usage rate.

Practical implications
Brick-and-mortar retailers can compete with digitization by using mobile messages, as users’ intention to redeem is quite high. However, they should be aware of the privacy concerns preventing some customers from using these apps.

Originality/value
Current research highlights the importance of digitization in retailing by using new technologies for brick-and-mortars, e.g., mobile messages as part of mobile targeting. This study provides evidence of the potential risks and benefits of sending mobile messages to customers in a different context.