bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective analysis of rapid drug desensitization with biologic agents: A single center experience
Authors: Unutmaz Erkaya Döne Gülçin , Bayrak Durmaz Makbule Seda , Görgülü Akın Begüm , Bavbek Sevim 
Published: October 2024

AbstractBackgroundFollowing the increased use of biological agents, a subset of patients experiences hypersensitivity reaction (HSR). We reported our experience with rapid drug desensitization (RDD) to nine biologics (rituximab, infliximab, cetuximab, trastuzumab, pertuzumab, nivolumab, brentuximab, tocilizumab and filgrastim) and identified risk factors for breakthrough reactions (BTRs).MethodThis was a retrospective review (2013–2022) of patients with immediate HSRs to biological agents. Initial HSRs were classified as grade 1, 2, or 3 in their severity. Skin prick tests (SPT)/intradermal tests (IDT) were performed using implicated agents. The phenotypes of HSRs were defined as Type I, cytokine‐release syndrome (CRS), mixed reactions (cytokine‐release + type I) based on history, clinical presentations and skin tests with implicated biologicals. A 12‐step RDD protocol was used.ResultsThe study comprised 45 patients (F/M: 31/14, median age: 55 (range: 20–69)). Majority of the patients reacted at the first infusion (n: 29/45, 64.4%). The majority of initial HSRs were grade 3 (n: 24/45, 53.3%) and grade 2 (n: 21/45, 46.6%); none were grade 1. Initial reactions were presented as type I (n: 20/45, 44.4%), CRS (n: 12/45, 26.6%) and mixed (n: 13/45, 28.8%). A total of 258 RDDs were performed and 98.4% of them were completed successfully. BTRs occurred in 36/258 (13.9%) infusions of RDDs. There was no significant association between the BTRs and age, drug cycle, SPT and IDT positivity, gender, comorbidities, or atopy.ConclusionIn our experience, 98.4% of 258 RDDs to biologics were successfully completed; RDD was safe and effective for our population.
Biofilm Demolition by [AuIII(N N)Cl(NHC)][PF6]2 Complexes Fastened with Bipyridine and Phenanthroline Ligands; Potent Antibacterial Agents Targeting Membrane Lipid
Authors: Sahu Priyanka , Chakraborty Sourav , Isab A. A. , Mandal Santi M. , Dinda Joydev 
Published: October 2024

AbstractThe development of new antibacterial drugs is essential for staying ahead of evolving antibiotic resistant bacterial (ARB) threats, ensuring effective treatment options for bacterial infections, and protecting public health. Herein, we successfully designed and synthesized two novel gold(III)‐ NHC complexes, [Au(1)(bpy)Cl][PF6]2 (2) and [Au(1)(phen)Cl][PF6]2 (3) based on the proligand pyridyl[1,2‐a]{2‐pyridylimidazol}‐3‐ylidene hexafluorophosphate (1⋅HPF6) [bpy=2,2′‐bipyridine; phen=1,10‐phenanthroline]. The synthesized complexes were characterized spectroscopically; their geometries and structural arrangements were confirmed by single crystal XRD analysis. Complexes 2 and 3 showed photoluminescence properties at room temperature and the time‐resolved fluorescence decay confirmed the fluorescence lifetimes of 0.54 and 0.62 ns respectively; which were used to demonstrate their direct interaction with bacterial cells. Among the two complexes, complex 3 was found to be more potent against the bacterial strains (Staphylococcus aureus, Gram‐positive and Pseudomonas aeruginosa, Gram‐negative bacteria) with the MIC values of 8.91 μM and 17.82 μM respectively. Studies revealed the binding of the complexes with the fundamental phospholipids present in the cell membrane of bacteria, which was found to be the leading cause of bacterial cell death. Cytotoxicity was evaluated using an MTT assay on 293 T cell lines; emphasizing the potential therapeutic uses of the Au(III)‐NHC complexes to control bacterial infections.
Working with Miraculous Mice: Mus musculus as a Model Organism
Authors: Standley Anick , Xie Jinhan , Lau Angelica WY , Grote Lauren , Gifford Andrew J. 
Published: October 2024

AbstractThe laboratory mouse has been described as a “miracle” model organism, providing a window by which we may gain an understanding of ourselves. Since the first recorded mouse experiment in 1664, the mouse has become the most used animal model in biomedical research. Mice are ideally suited as a model organism because of their small size, short gestation period, large litter size, and genetic similarity to humans. This article provides a broad overview of the laboratory mouse as a model organism and is intended for undergraduates and those new to working with mice. We delve into the history of the laboratory mouse and outline important terminology to accurately describe research mice. The types of laboratory mice available to researchers are reviewed, including outbred stocks, inbred strains, immunocompromised mice, and genetically engineered mice. The critical role mice have played in advancing knowledge in the areas of oncology, immunology, and pharmacology is highlighted by examining the significant contribution of mice to Nobel Prize winning research. International mouse mutagenesis programs and accurate phenotyping of mouse models are outlined. We also explain important considerations for working with mice, including animal ethics; the welfare principles of replacement, refinement, and reduction; and the choice of mouse model in experimental design. Finally, we present practical advice for maintaining a mouse colony, which involves adequate training of staff, the logistics of mouse housing, monitoring colony health, and breeding strategies. Useful resources for working with mice are also listed. The aim of this overview is to equip the reader with a broad appreciation of the enormous potential and some of the complexities of working with the laboratory mouse in a quest to improve human health. © 2024 The Author(s). Current Protocols published by Wiley Periodicals LLC.
The Stability Challenge of Furanic Platform Chemicals in Acidic and Basic Conditions
Authors: Kolykhalov Denis A. , Golysheva Anastasia N. , Erokhin Kirill S. , Karlinskii Bogdan Ya. , Ananikov Valentine P. 
Published: October 2024

AbstractThe transition toward renewable resources is pivotal for the sustainability of the chemical industry, making the exploration of biobased furanic platform chemicals derived from plant biomass of paramount importance. These compounds, promising alternatives to petroleum‐derived aromatics, face challenges in terms of stability under synthetic conditions, limiting their practical application in the fuel, chemical, and pharmaceutical sectors. Our study presents a comprehensive evaluation of the stability of furan derivatives in various solvents and under different conditions, addressing the significant challenge of their instability. Through systematic experiments involving GC–MS, NMR, FT–IR and SEM analyses, we identified key degradation pathways and conditions that either promote stability or lead to undesirable degradation products. These findings demonstrate the strong stabilizing effect of polar aprotic solvents, especially DMF, and reveal the dependence of furan stability on solvent and additive type. This research opens new avenues in the utilization of renewable furans by providing critical insights into their behavior under synthetic conditions, significantly impacting the development of sustainable materials and processes. The broad appeal of this study lies in its potential to guide the selection of conditions for the efficient and sustainable synthesis of furan‐based chemicals, marking a significant advance in green chemistry and materials science.
Distributed Autonomous Economic Control Strategy for the AC/DC Interconnected Microgrid Considering the Regulation Boundary of the Consensus Variable
Authors: Tan Haoyu , Wang Tingtao , Wang Yicong , Wang Jiaxu , He Ligang , Miao Shihong 
Published: October 2024

ABSTRACTThe autonomous economic control for the islanded AC/DC interconnected microgrid has various modes due to the restriction of the feasible regions of inner and inter‐microgrid resources. To properly handle the cooperative relationship between resources with different regulation characteristics and realize the frequency, voltage stability, and economic operation of the AC/DC interconnected microgrid, a distributed control strategy considering the regulation boundary of the consensus variable is proposed. Firstly, the influence of the variable feasible regions on the consensus control objective is analyzed, and the fundamental principle of the consensus control algorithm considering the variable regulation boundary is expounded. Secondly, the trilevel control strategy consisting of the local equipment control and inner and inter‐microgrid cooperative control is constructed. The local equipment control adopts droop control, and the cooperative control adopts consensus control to realize the elimination of the frequency and voltage deviation and the economic dispatch of active power within and between microgrids. Finally, the AC/DC interconnected microgrid model is built based on PSCAD/EMTDC, and the simulation results verify the effectiveness of the proposed control strategy.
Effects of Early Life Scarcity‐Adversity on Maturational Milestones in Male and Female Rats
Authors: Lauraine Erin , Oak Sasha , Nguyen Christine H. , Rincón‐Cortés Millie 
Published: October 2024

ABSTRACTAlthough many studies have shown a long‐term negative impact of early life adversity (ELA) in rodents, literature regarding its effects on maturational milestones in rats is scarce. Available evidence suggests that ELA interferes with normal growth and development in rodents and that effects may be sex‐dependent even at an early age. In accordance, we hypothesized that early life scarcity‐adversity would impair physical and reflex development in male and female rats. To test this, we used an early life resource scarcity paradigm based on reducing home cage bedding during postnatal days (PND) 2–9 and assessed physical landmarks by measuring weight gain, incisor presence, fur development, and eye opening. We also evaluated the impact of early life scarcity‐adversity on developmental reflexes by measuring surface righting and grasp reflexes, negative geotaxis, cliff avoidance, bar holding, and auditory startle. Early life scarcity‐adversity resulted in earlier complete lower incisor presence in males (PND 6), impaired surface righting (PND 6) and grasp reflexes (PND 8) in both sexes, and impaired cliff avoidance responses in females (PND 12). These results extend previous research examining the effects of ELA on developing male and female rodents by showing that it negatively impacts a subset of physical landmarks and developmental reflexes in a sex‐dependent manner.
Stable Ditriflates of D‐Glucose in the Synthesis of Iminosugars and Polyhydroxylated Pipecolic Acids
Authors: Balo Rosalino , Fernández Andrés , Reza David , López Pablo , Fleet George W. J. , Estévez Ramón J. , Estévez Juan C. 
Published: October 2024

AbstractA synthesis of the five membered iminosugar DAB and a divergent synthesis of the six membered iminosugar 1‐dehydromannojirimycin (DMJ) and the corresponding sugar imino acid are reported. They involve double nucleophilic displacements of a D‐xylose ditriflate by benzyl carbazate and a D‐glucose ditriflate by allyl amine, respectively. They are followed by a similar protocol consisting of hydrolysis and oxidation or reduction of the resulting bicyclic glycosides. This allowed DMJ to be obtained from the cheap sugar D‐glucose.
High‐Performance MCNTs@MoS2(1‐x)Se2x Nanocomposites in Catalytic Hydrogen Evolution
Authors: Jiang Huixin , Zhao Wenjing , Cui Mengyu , Zhang Xinyi , Song Xinrong , Wang Chuangye 
Published: October 2024

AbstractAdvances in electrocatalysis require the development of high specific surface area materials with high electron conductivity. In this study, a series of MCNTs@MoS2(1‐x)Se2x nanocomposites has been prepared for application in catalytic hydrogen evolution. A uniform growth of MoS2(1‐x)Se2x nanoflower spheres on MCNTs has been achieved, circumventing stacking and aggregation. The introduction of the conducting material accelerated the electron transport rate in the electrode reaction. Structural characterization has confirmed that S doping increased the specific surface area of the catalyst, exposing more edge defects. As a result, the MCNTs@MoS2(1‐x)Se2x nanocomposites exhibited enhanced catalytic activity. Electrochemical tests have established that MCNTs@MoS1.5Se0.5 possessed the lowest overpotential (146 mV) at a current density of 10 mA/cm2 with the smallest Tafel slope (45.1 mV/dec).
Impact of Carbon Fiber‐Reinforced Polymer Sheets and Bolt Diameter on the Seismic Performance Enhancement of Steel Beam‐Column Joints
Authors: Amin Fayiz , Waqas Hafiz Ahmed , Ali Ijaz , Waseem Muhammad , Asif Muhammad , Majid Khan Abdul , Leta Megersa Kebede 
Published: October 2024

ABSTRACTBeam‐column joints are pivotal for ensuring the resilience of prefabricated steel structures under various loading conditions. Following the major earthquakes of the 1990s, semi‐rigid bolted connections emerged as a promising alternative to traditional welded connections. This study investigates a fully prefabricated Intermediate Beam‐Column Joint (IBCJ) with extended endplates, renowned for its excellent seismic resistance. While significant progress has been made in existing research, there is still a need to thoroughly examine the tension capacity of IBCJs concerning bolt size and explore the potential of Carbon Fiber‐Reinforced Polymer (CFRP) sheets to enhance joint performance under seismic loading. Using the finite element method, this research evaluates the performance of IBCJ under both monotonic and cyclic loading conditions. After validation with experimental data, the study examines various bolt diameters to assess their tension capacity, ductility ratio, secant stiffness, and energy dissipation capacity. The findings indicate that larger bolts exhibit higher ultimate capacities and reduced deformation at failure. Additionally, the study investigates the optimal placement and configuration of CFRP sheets, identifying the backside of the endplates as the most effective location. The application of CFRP significantly enhances bolt tension capacity by up to 1.2 to 1.3 times, demonstrating its potential in reducing bolt failure risk and improving structural reliability under seismic conditions. The superior performance of CFRP‐strengthened bolts can play a crucial role in the design and retrofitting of prefabricated steel structures, potentially contributing to the improvement of existing standards and practices of seismic enhancement of IBCJ.
5G Network Slicing as a Service Enabler for the Automotive Sector
Authors: Candal‐Ventureira David , Rúa‐Estévez José Manuel , Fondo‐Ferreiro Pablo , Gil‐Castiñeira Felipe , Fernández‐Barciela Antonio , González‐Castaño Francisco Javier , Diéguez‐Pazo Emilio , Fernández‐Ferreira Luis 
Published: October 2024

ABSTRACTNetwork slicing, a key technology introduced in 5G standards, enables mobile networks to simultaneously support a wide range of heterogeneous use cases with diverse quality of service (QoS) requirements. This work discusses the potential benefits of network slicing for the automotive sector, encompassing manufacturing processes and vehicular communications. The review of the state of the art reveals a clear gap regarding the application of network slicing from the perspective of industrial verticals such as automotive use cases and their specific requirements. Departing from this observation, we first identify limitations of previous cellular technologies and open challenges for supporting the data services required. Then we describe network slicing as an enabler to face these challenges. We present an analysis of the cost equilibrium for network slicing to be effective for car manufacturers, and tests in real 5G networks that demonstrate the performance improvement in OTA updates coexisting with other services.
Pushing the boundaries for fuel discovery with a multiview features fusion approach
Authors: Zhang Dehai , Zhao Di , Liang Jiashu , Ma Yu , Chen Zheng 
Published: October 2024

AbstractGlobal warming poses a serious challenge to the human environment, prompting us to rapidly develop new environmentally friendly fuels. However, the time and cost required to determine the physical properties of fuels are constrained by the related industries. In this paper, we propose a multiview features fusion method based on neural networks. This method uses the eight graph neural networks models as the basis of the multichannel network coordinator to extract the compound's molecular feature; also the functional groups in the compound are embedded with molecule weight as functional groups feature, and finally, combining the molecular view with the functional groups view for the prediction of compound flash point (FP). We used a data set consisting of 2200 hydrocarbons and oxygenated compounds for model training and testing. The results show that the model performance is improved in both after feature fusion. Finally, the ablation experiments demonstrate that the use of this method is effective and provides a new idea for fast and accurate screening of fuels. The Attentive FP‐FG model was the most effective, with a mean absolute error of 4.395 K, root mean square error of 5.854 K, and R‐squared score (R2) of 0.986.
Regularizations of forward‐backward parabolic PDEs
Authors: Geldhauser Carina 
Published: October 2024

AbstractForward‐backward parabolic equations have been studied since the 1980s, but a mathematically rigorous picture is still far from being established. As quite a number of new papers have appeared recently, we review in this work the current state of the art. We focus our analysis on the status quo regarding the three most common types of regularizations, namely semidiscretization, the viscous approximation, and regularization with higher order spatial derivatives.
How do clinical placements influence the career decisions of new‐graduate physiotherapists in Australia? A qualitative exploration
Authors: Singh Lakhvir , Martin Romany , Mandrusiak Allison , Phua Rachel , Al‐Hashemy Hussan , Forbes Roma 
Published: October 2024

AbstractBackgroundThe variables that contribute to positive and negative experiences of clinical education amongst student physiotherapists are well established. Multiple stakeholders are invested in the ongoing success of physiotherapy clinical placements given workforce challenges within the profession and the emerging relationship between clinical placements and new‐graduate recruitment. However, little is known about the relationship between clinical placement experiences and the career decisions of new‐graduate physiotherapists.PurposeTo explore the influence of clinical placement experiences on new‐graduate physiotherapists' career intentions and decision making.MethodsA qualitative study which used a general inductive approach. New‐graduate physiotherapists (n = 18) were recruited through a snowball sampling approach and participated in semi‐structured interviews. Ethical approval was obtained from The University of Queensland.ResultsFour overarching themes were generated; (1) clinical placements impact career decisions, (2) placements as a trial for future employment to identify professional preferences, (3) feeling valued as a team member, and (4) clinical educators’ shape placement experiences.Discussion and ConclusionClinical placements play a significant role in directing new‐graduate physiotherapists’ careers, with clinical placement viewed as an opportunity to explore one's career options. A complex interplay of clinical and nonclinical variables was acknowledged by new‐graduates, with positive experiences during clinical placements considered to increase new‐graduate physiotherapist intentions to work in similar settings or contexts. Factors that contributed to positive experiences included accessible mentorship from clinical educators with regular feedback, and opportunities for the students’ contribution and clinical capacity to be acknowledged and valued. Recommendations are made for creating supportive workplace environments for clinical education and include prioritizing supportive mentorship.Implications for Physiotherapy PracticeClinical placement providers intending to recruit new‐graduates who have attended their workplace as students may benefit from implementing strategies that assist students to feel supported as valued members of the team. Additionally, the findings of this study may guide education providers when considering the training delivered to new and existing clinical placement sites with the aim of providing supported student learning environments.
Epikarst Controls of Runoff Composition in Subterranean Stream After Rainstorm Events
Authors: Zhao Heng , Zhou Hong , Huang Kun , Pan Yi , Peng Yinong , He Xinhui , Wang Siqi , Wan Junwei 
Published: October 2024

ABSTRACTEpikarst plays a critical role in karst water circulation, however, its studies have often been limited to small springs or basins, ignoring its importance in larger, highly karstified subterranean streams. This study focused on the Longlingong (LLG) subterranean stream system, where the discharge and electrical conductivity (EC) of the subterranean stream outlet for 2.5 years, and found that 85% of all rainstorm events monitored during this period showed a pattern of increasing and then decreasing EC. High‐resolution hydrochemistry monitoring was conducted at the outlet during a rainstorm event when this response pattern occurred. Simultaneously, epikarst water (EW), saturated zone fissure karst water (FW), and surface water (PW) from this system were collected as three recharge sources for hydrochemical analyses based on the results of the field investigations, and end‐member mixing analyses were performed using the EMMA‐MIX model. These combined methods can accurately characterise the response of the subterranean stream system to rainstorm events, assess the contribution and response of individual recharge sources throughout the rainstorm, and reveal the mechanisms involved. The results indicate that the increase in EC is primarily driven by changes in HCO3− concentration resulting from the rapid discharge of EW through sinkholes and shafts. EW contributes 28.7% of the rain‐induced subterranean stream runoff, exceeding FW. The epikarst exhibits a rapid response to rainstorms, as evidenced by a remarkable 681% increase in EW discharge following a rainstorm event. Flood peaks in the subterranean stream are mainly composed of PW (44%) and EW (43.6%). This study highlights the key role of the epikarst as a karst groundwater reservoir. The sensitivity of the epikarst to rainstorms, particularly its role in facilitating rapid piston‐like migration of EW during initial runoff, highlights its significant influence on discharge and hydrochemistry. This research contributes to a deeper understanding of the function of epikarst within highly karstified subterranean streams.