bluuebunny/crossref_metadata_2025_split huggingface dataset:
Temporal Trends in Mental Health Service Utilization across Outpatient and Acute Care Sectors: A Population-Based Study from 2006 to 2014
Authors: Chiu Maria , Gatov Evgenia , Vigod Simone N. , Amartey Abigail , Saunders Natasha R. , Yao Zhan , Pequeno Priscila , Kurdyak Paul 
Published: January 2018

Objective: Although evidence suggests that treatment seeking for mental illness has increased over time, little is known about how the health system is meeting the increasing demand for services. We examined trends in physician-based mental health service use across multiple sectors. Method: In this population-based study, we used linked health-administrative databases to measure annual rates of mental health–related outpatient physician visits to family physicians and psychiatrists, emergency department visits, and hospitalizations in adults aged 16+ from 2006 to 2014. We examined absolute and relative changes in visit rates, number of patients, and frequency of visits per patient, and assessed temporal trends using linear regressions. Results: Among approximately 11 million Ontario adults, age- and sex-standardized rates of mental health–related outpatient physician visits declined from 604.8 to 565.5 per 1000 population over the study period ( Ptrend = 0.04). Over time, the rate of visits to family physicians/general practitioners remained stable ( Ptrend = 0.12); the number of individuals served decreased, but the number of visits per patient increased. The rate of visits to psychiatrists declined ( Ptrend < 0.001); the number of individuals served increased, but the number of visits per patient decreased. Concurrently, visit rates to emergency departments and hospitals increased (16.1 to 19.7, Ptrend < 0.001 and 5.6 to 6.0, Ptrend = 0.01, per 1000 population, respectively). Increases in acute care service use were greatest for anxiety and addictions. Conclusions: The increasing acute care service use coupled with the reduction in outpatient visits suggest, overall, an increase in demand for mental health care that is not being met in ambulatory care settings.
Lateral and Posterior Approaches in Hemiarthroplasty
Authors: Hongisto M. T. , Nuotio M. S. , Luukkaala T. , Väistö O. , Pihlajamäki H. K. 
Published: January 2018

Purpose: Hemiarthroplasty is a common treatment for patient with a fragility displaced femoral neck fracture. We compared lateral and posterior approaches with respect to need for mobility aids, mobility level, living arrangements, pain, hip dislocation, and survival 12 months after hip fracture. Methods: A total of 393 fragility femoral neck fracture patients aged 65 years or more who underwent hemiarthroplasty were observed for 12 months. Patient information was collected on admission, during hospitalization, and by telephone interview 1 year after the hip fracture. A total of 269 patients were included in the final analysis. Results: At 1 year after hip fracture, more patients undergoing hemiarthroplasty with the posterior approach (22%) survived without mobility aids compared to those with the lateral approach (12%; p = 0.026). Multivariate logistic regression analysis revealed that the need for mobility aids 1 year after hip fracture was significantly predicted by the use of mobility aids before the fracture (odds ratio = 13.46, 95% confidence interval = 4.29–42.25), age ≥85 years (odds ratio = 3.85, 95% confidence interval = 1.09–13.44), male sex (odds ratio = 3.59, 95% confidence interval = 1.05–12.22), and lateral approach (odds ratio 2.73, 95% confidence interval 1.15–6.50). The posterior approach resulted in four (3.4%) dislocated hips, compared with none by the lateral approach. Survival, mobility level, pain in the operated hip, and living arrangements 1 year postoperatively were not significantly different between groups. Conclusion: Hemiarthroplasty using a lateral approach predisposed to the need for ambulatory aids 1 year after hip fracture. The posterior approach, however, predisposed to hip dislocation. Patient selection must be considered when deciding the appropriate surgical approach.
Comparison of Computer-Guided Versus Standard Insulin Infusion Regimens in Patients With Diabetic Ketoacidosis
Authors: Ullal Jagdeesh , Aloi Joseph A. , Reyes-Umpierrez David , Pasquel Francisco J. , McFarland Raymie , Rabinovich Marina , Umpierrez Guillermo E. 
Published: January 2018

Background: This study was performed to investigate the efficacy of Glucommander (GM) (Glytec®), a computer-based algorithm versus standard (paper form-based) continuous insulin infusion (CII) in the treatment of patients with diabetic ketoacidosis (DKA). Methods: This was a retrospective multicenter study involving 2665 patients with DKA treated with either GM (n = 1750) or standard protocols (n = 915) across 34 institutions in the United States. GM estimates the rate of CII using an insulin sensitivity factor referred to as a “multiplier” that ranges between 0.01 and 0.03. Outcomes of interest were differences in time to resolve DKA (blood glucose [BG] <200 mg/dL and bicarbonate < 18 mmol/L) and number of hypoglycemic events defined as a BG <70 mg/dl. Results: Treatment with GM was associated with lower rates of hypoglycemia during the time of the insulin drip (12.9% vs 35%, P = .001), faster time to normalization of blood glucose (9.7 ± 8.9 vs 10.97 ± 10.2 hours, P = .0001) and resolution of metabolic acidosis (13.6 ± 11.8 vs 17.3 ± 19.6 hours, P = .0001), and shorter hospital length of stay (3.2 ± 2.9 vs 4.5 ± 4.8 days, P = .01) compared to standard care. Best treatment outcomes were achieved with an initial multiplier of 0.01 and a glucose target range between 120 and 180 mg/dl. Conclusion: The GM algorithm in DKA treatment resulted in lower rates of hypoglycemia and faster DKA resolution over standard paper-based algorithms. Prospective randomized clinical trials comparing the efficacy and cost of computer-based algorithms versus standard CII regimens are warranted.
Broncholithiasis associated with lower airway inflammation and subsequent pyothorax in a cat
Authors: Valls Sanchez Ferran , Stewart Jennifer , Bovens Catherine , Puig Jordi 
Published: January 2018

Case summary A 12-year-old female spayed domestic shorthair cat presented with history of a long-term chronic cough that had worsened during the previous 2 months. Thoracic radiographs revealed numerous mineral opacities throughout the lung fields. Multiple bronchial plugs of pale yellow material were present on bronchoscopy, consistent with broncholithiasis. Bronchoalveolar lavage cytology revealed a mild neutrophilic inflammation and bacterial culture was negative. The cat was diagnosed with chronic inflammatory lower airway disease and broncholithiasis, suspected to be due to mineralisation of secretions in the bronchial lumen. The cat was treated for 6 years with oral prednisolone and responded well to treatment. Six years later, the cat developed severe respiratory distress and died. Post-mortem examination identified chronic multifocal broncholithiasis, pulmonary abscessation and pyothorax. Relevance and novel information Broncholithiasis is a very rare condition in feline medicine; however, we are reporting a new case and it should be considered as a differential diagnosis for chronic coughing in cats, especially when other common causes have been ruled out and the radiographic findings are suggestive of it. We hypothesise that pathogenesis of the pulmonary abscessation and pyothorax in our patient was, at least partially, due to broncholithiasis. Pleural disease should be considered a complication of broncholithiasis.
Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice
Authors: Girard-Guyonvarc’h Charlotte , Palomo Jennifer , Martin Praxedis , Rodriguez Emiliana , Troccaz Sabina , Palmer Gaby , Gabay Cem 
Published: January 2018

Key PointsEndogenous IL-18BP is critical to prevent severe MAS on repetitive TLR9 stimulation. IL-18BP deficiency is associated with elevated plasma levels of free IL-18 and an enhanced IFN-γ molecular signature in TLR9-induced MAS.
GPVI signaling is compromised in newly formed platelets after acute thrombocytopenia in mice
Authors: Gupta Shuchi , Cherpokova Deya , Spindler Markus , Morowski Martina , Bender Markus , Nieswandt Bernhard 
Published: January 2018

Key PointsNewly formed young platelets produced by MKs in response to acute thrombocytopenia display a selective GPVI-ITAM signaling defect. This signaling defect protects mice from occlusive arterial thrombus formation.
The impact of aging on primate hematopoiesis as interrogated by clonal tracking
Authors: Yu Kyung-Rok , Espinoza Diego A. , Wu Chuanfeng , Truitt Lauren , Shin Tae-Hoon , Chen Shirley , Fan Xing , Yabe Idalia M. , Panch Sandhya , Hong So Gun , Koelle Samson , Lu Rong , Bonifacino Aylin , Krouse Allen , Metzger Mark , Donahue Robert E. , Dunbar Cynthia E. 
Published: January 2018

Key PointsGenetic barcoding of HSPCs in aged macaques reveals impaired long-term clonal output from multipotent HSPCs. Aged macaques showed prolonged contributions from lineage-biased HSPCs and late clonal expansions.
Diagnostic Utility of Molecular and Imaging Biomarkers in Cytological Indeterminate Thyroid Nodules
Authors: de Koster Elizabeth J , de Geus-Oei Lioe-Fee , Dekkers Olaf M , van Engen-van Grunsven Ilse , Hamming Jaap , Corssmit Eleonora P M , Morreau Hans , Schepers Abbey , Smit Jan , Oyen Wim J G , Vriens Dennis 
Published: January 2018

AbstractIndeterminate thyroid cytology (Bethesda III and IV) corresponds to follicular-patterned benign and malignant lesions, which are particularly difficult to differentiate on cytology alone. As ~25% of these nodules harbor malignancy, diagnostic hemithyroidectomy is still custom. However, advanced preoperative diagnostics are rapidly evolving.This review provides an overview of additional molecular and imaging diagnostics for indeterminate thyroid nodules in a preoperative clinical setting, including considerations regarding cost-effectiveness, availability, and feasibility of combining techniques. Addressed diagnostics include gene mutation analysis, microRNA, immunocytochemistry, ultrasonography, elastosonography, computed tomography, sestamibi scintigraphy, [18F]-2-fluoro-2-deoxy-d-glucose positron emission tomography (FDG-PET), and diffusion-weighted magnetic resonance imaging.The best rule-out tests for malignancy were the Afirma® gene expression classifier and FDG-PET. The most accurate rule-in test was sole BRAF mutation analysis. No diagnostic had both near-perfect sensitivity and specificity, and estimated cost-effectiveness. Molecular techniques are rapidly advancing. However, given the currently available techniques, a multimodality stepwise approach likely offers the most accurate diagnosis, sequentially applying one sensitive rule-out test and one specific rule-in test. Geographical variations in cytology (e.g., Hürthle cell neoplasms) and tumor genetics strongly influence local test performance and clinical utility. Multidisciplinary collaboration and implementation studies can aid the local decision for one or more eligible diagnostics.
Initial experience with 18F-sodium fluoride (NaF) PET-CT: a viable functional biomarker in symptomatic Os acromiale
Authors: Usmani Sharjeel , Marafi Fahad , Esmail Abdulredha , Ahmed Najeeb 
Published: January 2018

Objective:
Os acromiale (OA) is a failure of complete fusion of the acromial process. It is usually asymptomatic and discovered incidentally. OA can contribute to shoulder impingement symptoms and rotator cuff tears. 18F Sodium Fluoride (NaF) Positron Emission Tomography -CT (PET-CT) is an emerging and highly sensitive modality for oncological skeletal staging, and can show a variety of non-malignant uptake. We have analysed the relationship between 18F-NaF uptake in OA and associated symptoms of shoulder pain.

Methods:
Study population included 21 patients (mean age 60.2 ± 12 years; 13 females and 8 males) with OA who underwent PET-CT scan by injecting 2.22 MBq kg−1 of 18F-NaF. The relationship between 18F-NaF uptake and OA as a cause of pain was analysed. A 3-point grading system was used to evaluate uptake of 18F-NaF.

Results:
In total 27 OA (12 symptomatic and 15 asymptomatic) were enrolled. All symptomatic OA showed focal increase tracer uptake of Grade 2, while asymptomatic OA did not have significant activity Grade 0 (n = 11) and Grade 1 (n = 4).

Conclusion:
18F-NaF PET-CT appears to be a useful adjunct in the assessment of symptomatic OA with its particular strength being its high negative predictive value.

Advances in knowledge:
18F-NaF PET-CT may be used as an ancillary tool for identifying symptomatic OA as a cause of shoulder pain in cases where other obvious causes of shoulder pain have been excluded.
Long-term follow-up after childhood cancer in France supported by the SFCE—force and weakness—current state, results of a questionnaire and perspectives
Authors: Demoor-Goldschmidt Charlotte , Tabone Marie-Dominique , Bernier Valérie , de Vathaire Florent , Berger Claire 
Published: January 2018

Objective:
The survival rate of children treated for cancer is currently about 80% at 5 years and we estimate that about 50,000 adults in France have survived childhood cancer. In 2011, there was a call for projects relating to long-term follow-up (LTFU), which led to several studies being conducted. Five years later, we sent a questionnaire to present LTFU in France and describe its strengths and weaknesses and to establish appropriate steps that should be taken.

Methods:
A questionnaire was sent by email to all the members of the French Society of Childhood Cancers in spring 2016. The study involved 44 centres/hospitals with a Paediatric Oncology Department.

Results:
54 answers were analysed, provided by 31/44 (70%) centres working together with the French Society of Childhood Cancers. Screening is the main objective of LTFU care (90%). The main difficulties that arose were: lack of sufficient time to devote to this activity (57%), difficulties contacting adult childhood cancer survivors (aCCSs) (26%), aCCSs who ultimately did not show up to the consultation (19%), cost (15%), and lack of organization (13%). Seven LTFU programmes were identified: two regional organizations (Rhône Alpes and Grand Ouest), four centre-size organizations, and one national study (involving 15 Haematology Centres) relating to Child and Adolescent Leukaemia.

Conclusion:
LTFU is a major concern for French centres specialized in paediatric oncology. Organization is not well defined and difficulties still arise (Who are the best care providers? What frequency of care is most appropriate? etc.).

Advances in knowledge:
LTFU focused on health problems (physical, psychological, social, economic issues) that affect CCSs is needed to ensure that these patients regain the most optimal physical and emotional health possible. Practitioners suggest different ways to improve LTFU, such as national co-operation with Epidemiology Registers to promote homogenous LTFU care.
Atuação da autoridade policial e do poder judiciário no combate à violência doméstica contra a mulher na cidade de São Luís/MA
Authors: Castro Bruno Denis Vale , Silva Artenira Da Silva e 
Published: January 2018

Considerando os números crescentes de casos de violência doméstica contra a mulher e o déficit de estudos voltados para uma avaliação da estrutura das políticas públicas a níveis locais e seus efeitos para coibir a violência de gênero, este artigo tem o objetivo de realizar um levantamento de informações e dados referentes às prestações dos serviços e atuação da Delegacia Especial da Mulher e da Vara Especializada da Mulher e da Violência Doméstica de São Luís/MA responsáveis, respectivamente, pelo atendimento e julgamento dos possíveis crimes de violência doméstica contra a mulher, de modo a discutir as principais dificuldades encontradas por esses órgãos em suas atuações. Evidenciou-se que o atendimento a mulheres vítimas de violência doméstica ou intrafamiliar exige uma qualificação técnica específica, uma vez que demanda uma atuação transdisciplinar daqueles que atuam frente ao fenômeno aludido, seja nas Delegacias Especiais da Mulher seja nas Varas Especializadas. Além disso, concluiu-se que a Vara de Violência Doméstica e Familiar Contra a Mulher da Cidade de São Luís/MA precisa ressignificar a sua atuação diante do inexpressivo número de processos que possuem decisões de mérito e condenações transitadas em julgado desde sua criação em 2008. Apenas focar em concessão de medidas protetivas de urgência, considerando-as ações “satisfativas”, mostra-se como sendo uma restrição demasiada do escopo de proteção que a Lei 11.340/2006 pretende alcançar. Sem instruções processuais de cunho explicitamente transdisciplinar que visibilize o fenômeno da violência de gênero em suas especificidades e complexidade, não há garantia efetiva de proteção de mulheres violentadas, tampouco justiça.
Política pública e direito à educação infantil de boa qualidade: a situação das UMEIs na municipalidade de Belo Horizonte
Authors: Rocha Lucas Salles Moreira , Oliveira Márcio Luís De 
Published: January 2018

O tema do artigo centra-se na dificuldade da municipalidade de Belo Horizonte – Estado de Minas Gerais, Brasil – em assegurar a universalização do acesso ao ensino infantil de qualidade em suas Unidades Municipais de Educação Infantil (UMEIs), o que tem causado grande volume de ações judiciais em face da municipalidade, inviabilizando a adequada gestão administrativa da questão. Nesse contexto, o estudo sugere a adoção do “subsídio escolar” como política pública complementar, a título transitório ou permanente, para solucionar ou reduzir os efeitos negativos da situação. Na elaboração do artigo, foi utilizada a metodologia analítico-descritiva do problema fático-jurídico, com o apoio de métodos jurídico-dogmáticos e com a apresentação de dados estatísticos, além da consulta à legislação, à jurisprudência e à doutrina. O artigo tem como marco teórico estruturante o acesso universal ao ensino infantil de boa qualidade como direito fundamental e direito humano a ser viabilizado pelo Estado, com a colaboração da iniciativa privada. A partir do marco teórico, aborda-se a questão dos custos para a implementação dos direitos prestacionais primários e da necessidade de adoção de políticas públicas que contribuam, de modo sustentável, para a ampliação do acesso às escolas infantis de qualidade.
Subindo a escada: o uso estratégico de padrão estrangeiro para o aperfeiçoamento da liberdade de expressão na Internet
Authors: Silva Alice Rocha da , Soares Filipe Rocha Martins 
Published: January 2018

A conexão entre endereços digitados em um navegador de Internet e o conteúdo dos sites é promovida por um padrão desenvolvido à luz da legislação dos Estados Unidos e sob a influência direta do governo deste país. Tal unilateralidade na conformação de padrões com impactos globais pode ser um problema, à medida que países ricos desenvolvem mecanismos de afirmação de seu poder, com a consequente exclusão das nações em desenvolvimento. No entanto, argumentar-se-á, neste artigo, que, no tocante à liberdade de expressão na Internet, embora haja um notável déficit de legitimidade na elaboração do padrão, o atual modelo assegura oportunidades de desenvolvimento para os países que não participaram deste processo. Defender-se-á, assim, que o uso estratégico de um padrão estrangeiro que privilegie a livre circulação de informações tem o potencial de promover mudanças benéficas às nações em desenvolvimento. O assunto é relevante porque a liberdade de expressão seria ameaçada caso se adotassem referenciais técnicos desenvolvidos sob a influência de atores interessados em tolher a livre manifestação de pensamentos. Logo, almeja-se demonstrar, por meio de revisão bibliográfica, análise de decisões judiciais e breve alusão ao Direito estrangeiro, que, na situação em apreço, a limitação da legitimidade é compensada pelo ganho relativamente ao aprimoramento da liberdade de expressão. Tal premissa conduzirá à reflexão sobre as estruturas de participação internacionais, no sentido de se comprovar que um sistema de decisões majoritário nem sempre refletirá valores democráticos na esfera global.
Carl Julius Senff (1804–1832) – ein Kurzes Künstlerleben als Architekt, Zeichner und Grafiker
Authors: Vogel Gerd-Helge 
Published: January 2018

Carl Julius Senff was a talented artist with wide-ranging knowledge of art and architecture, who first received art lessons from his father Carl August Senff in Tartu. From 1823 to 1827, Carl Julius Senff studied philosophy at the University of Tartu and illustrated several publications while still a student. For example, in 1825 he published a textbook on perspective called Perspective für Landschaftsmaler zum Selbststudium.Although Carl Julius Senff’s life was cut short, he was still able to travel extensively. In 1829, he travelled to Jena for three years where he acquired a doctoral degree in philosophy. His earliest drawings also date from this period and, based on them, we can also partially reconstruct the route of his travels. From Jena, he travelled to Prague, Vienna and Munich. In 1831, he travelled to Italy where he lived in Rome. The young artist and scholar was destined to become the new professor of architecture at the University of Tartu but, unfortunately, Carl Julius Senff fell ill during his last trip and died in Milan.The article is based to a great degree on unpublished archival documents as well as the personal correspondence of Carl Julius Senff and his father Carl August Senff.
The effects of apomorphine on paracetamol-induced hepatotoxicity in rats
Authors: Sehitoglu Muserref Hilal , Yayla Muhammet , Kiraz Asli , Oztopuz Rahime Ozlem , Bayir Yasin , Karaca Turan , Khalid Sumbul , Akpinar Erol 
Published: January 2018

It is becoming progressively more understandable that overdose of paracetamol in both humans and animals causes severe hepatotoxicity. Apomorphine is known as a neuroprotective agent. Due to the protective effect, apomorphine had been tested in experimental studies on different models. Findings obtained through series of expriments suggested that apomorphine may also be useful in liver toxicity. The aim of this study is to investigate the relationship among the hepatoprotective mechanism of apomorphine and to determine the possible role of apomorphine on paracetamol-induced hepatotoxicity in rats. 30 Sprague Dawley rats (adult male) were distributed into 5 groups. Group 1 was the control group and did not receive any medication. Group 2 received only paracetamol 2 g/kg by intragastric gavage to induce hepatotoxicity. Groups 3 and 4 were given apomorphine 1 mg/kg and 2 mg/kg by intraperitoneal injection, respectively. Groups 3 and 4 were given 2g/kg of Paracetamol. In Group 5, rats were treated with 2 mg/kg of apomorphine. Drug-treated rats were given food for the next 24 h until they were sacrified. Moreover, we also performed AST, ALT measurements in serum, MDA and SOD levels in liver tissues and histopathological analysis of the liver in all groups. Apomorphine had positive effects on both liver enzymes, oxidative stress markers and histopathological results in paracetamol-induced hepatotoxicity. Additionally, apomorphine at 2 mg/kg dose was significantly more protective as compared to 1 mg/kg as evidenced by the histopathological examination results. It was thought that apomorphine was found hepatoprotective on paracetamol-induced hepatotoxicity, especially at higher doses such as 2 mg/kg.