bluuebunny/crossref_metadata_2025_split huggingface dataset:
ОСОБЛИВОСТІ КОРЕКЦІЇ ПОКАЗНИКІВ ЧЕРВОНОЇ КРОВІ ПРИ ХРОНІЧНИХ ЮВЕНІЛЬНИХ АНОМАЛЬНИХ МАТКОВИХ КРОВОТЕЧАХ
Authors: Dobryansʹka V. Yu. , Bahniy L. V. , Heryak S. M. , Yakymchuk V. D. , Kolochun H. V. , Bahniy N. I. , Mavdrik Z. Ya. , Khinochyk V. M. 
Published: May 2016

<p>Аномальні маткові кровотечі у підлітковому періоді, за даними літератури, складають понад 20 % усіх гінекологічних захворювань дівчаток.<br />Тривала чи значна за об’ємом менструація призводить до розвитку залізодефіцитної анемії як крайнього ступеня прояву дефіциту депонованого заліза. Тому сучасні принципи лікування аномальних маткових кровотеч ювенільного віку мають на меті зупинку кровотечі (гемостатиками, гормональний чи хірургічний гемостаз), її профілактику шляхом нормалізації менструального циклу, в тому числі відновлення депо заліза і рівня гемоглобіну в крові. У кожному разі появи кровотеч у підлітковому віці, їх лікування та спостереження повинно розпочинатися в умовах стаціонару.</p>
ХАРЧУВАННЯ ХВОРИХ З УРАЖЕННЯМ ЖОВЧНОГО МІХУРА НА ФОНІ ОЖИРІННЯ З УРАХУВАННЯМ КОМПОНЕНТНОЇ БУДОВИ ТІЛА ТА ЛІПІДНОГО ОБМІНУ
Authors: Matyukha L. F. , Yakubovsʹka I. A. 
Published: May 2016

<p>Харчування є одним з основних факторів, який визначає стан здоров’я людини та впливає на розвиток захворювань. На даний час метаболічний синдром (МС) виявляють у 25 % дорослого населення планети,<br />серед осіб віком понад 60 років – у 45 %, до того ж, за останні роки відзначається стійке зростання розвитку МС серед молоді. Відомо, що МС супроводжується метаболічним ураженням печінки, а також є фактором ризику розвитку ураження біліарної системи – холестеринового холелітіазу, холестерозу жовчного міхура. Збільшення частоти обмінних уражень жовчного міхура асоціюється зі зростанням захворюваності на ожиріння, метаболічного синдрому, цукрового діабету. Патологія жовчовивідних шляхів займає одне з чільних місць у гастроентерології, а дисфункція жовчного<br />міхура (ЖМ) зустрічається у кожної п'ятої дорослої людини. Численні дослідження свідчать про те, що хронічний холецистит та дисфункції ЖМ<br />асоціюються з порушеннями холесекреторної функції печінки.</p>
РАННІ МАРКЕРИ СИСТЕМНОГО АТЕРОСКЛЕРОЗУ У ХВОРИХ МОЛОДОГО ВІКУ, ЯКІ ПЕРЕНЕСЛИ ГОСТРИЙ ІНФАРКТ МІОКАРДА
Authors: Mykulyak V. R. , Zorya L. V. , Trach N. I. 
Published: May 2016

<p>На сьогоднішній день доведено, що товщина комплексу інтима-медіа (КІМ) – важливий предиктор розвитку серцево-судинної та церебральної патології.</p>
Pulmonary Vein Antrum Isolation in Patients With Paroxysmal Atrial Fibrillation
Authors: Gökoğlan Yalçin , Mohanty Sanghamitra , Güneş Mahmut F. , Trivedi Chintan , Santangeli Pasquale , Gianni Carola , Asfour Issa K. , Bai Rong , Burkhardt J. David , Horton Rodney , Sanchez Javier , Hao Steven , Hongo Richard , Beheiry Salwa , Di Biase Luigi , Natale Andrea 
Published: May 2016

Background—
We report the outcome of pulmonary vein (PV) antrum isolation in paroxysmal atrial fibrillation (AF) patients over more than a decade of follow-up.

Methods and Results—
A total of 513 paroxysmal AF patients (age 54±11 years, 73% males) undergoing catheter ablation at our institutions were included in this analysis. PV antrum isolation extended to the posterior wall between PVs plus empirical isolation of the superior vena cava was performed in all. Non-PV triggers were targeted during repeat procedure(s). Follow-up was performed quarterly for the first year and every 6 to 9 months thereafter. The outcome of this study was freedom from recurrent AF/atrial tachycardia. At 12 years, single-procedure arrhythmia-free survival was achieved in 58.7% of patients. Overall, the rate of recurrent arrhythmia (AF/atrial tachycardia) was 21% at 1 year, 11% between 1 and 3 years, 4% between 3 and 6 years, and 5.3% between 6 and 12 years. Repeat procedure was performed in 74% of patients. Reconnection in the PV antrum was found in 31% of patients after a single procedure and in no patients after 2 procedures. Non-PV triggers were found and targeted in all patients presenting with recurrent arrhythmia after ≥2 procedures. At 12 years, after multiple procedures, freedom from recurrent AF/atrial tachycardia was achieved in 87%.

Conclusions—
In patients with paroxysmal AF undergoing extended PV antrum isolation, the rate of late recurrence is lower than what previously reported with segmental or less extensive antral isolation. However, over more than a decade of follow-up, nearly 14% of patients developed recurrence because of new non-PV triggers.
Simultaneous His Bundle and Left Ventricular Pacing for Optimal Cardiac Resynchronization Therapy Delivery
Authors: Padeletti Luigi , Pieragnoli Paolo , Ricciardi Giuseppe , Innocenti Lisa , Checchi Luca , Padeletti Margherita , Michelucci Antonio , Picariello Francesco , Valsecchi Sergio 
Published: May 2016

Background—
Previous studies have investigated the role of intrinsic conduction in optimizing cardiac resynchronization therapy. We investigated the role of fusing pacing-induced activation and intrinsic conduction in cardiac resynchronization therapy by evaluating the acute hemodynamic effects of simultaneous His-bundle (HIS) and left ventricular (LV) pacing.

Methods and Results—

We studied 11 patients with systolic heart failure and left bundle-branch block scheduled for cardiac resynchronization therapy implantation. On implantation, LV pressure–volume data were determined via conductance catheter. Standard leads were placed in the right atrium, at the right ventricular apex, and in a coronary vein. An additional electrode was temporarily positioned in the HIS. The following pacing configurations were systematically assessed: standard biventricular (right ventricular apex+LV), LV-only, HIS, simultaneous HIS and LV (HIS+LV). Each configuration was compared with the AAI mode at multiple atrioventricular delays (AVD). In comparison with the AAI, right ventricular apex+LV and LV-only pacing resulted in improved stroke volume (85±32 mL and 86±33 mL versus 58±23 mL;
P
<0.001), stroke work, maximum pressure derivative, and systolic dyssynchrony at individually optimized AVD. The optimal AVD was close to the P-H interval in the majority of patients. By contrast, HIS-LV pacing improved hemodynamic indexes at all AVD (stroke volume >76 mL at all fixed intervals and 88±31 mL at optimal interval; all
P
<0.001).

Conclusions—
Standard right ventricular apex+LV and LV-only pacing enhanced systolic function and LV synchrony at individually optimized AVD close to the measured intrinsic P-H interval. By contrast, HIS+LV pacing yielded improvements, regardless of AVD setting. These findings support the hypothesis of the crucial role of intrinsic right ventricular conduction in optimal cardiac resynchronization therapy delivery.
Aerosol Impacts on Thermally Driven Orographic Convection
Authors: Nugent Alison D. , Watson Campbell D. , Thompson Gregory , Smith Ronald B. 
Published: May 2016

Abstract
Observations from the Dominica Experiment (DOMEX) field campaign clearly show aerosols having an impact on cloud microphysical properties in thermally driven orographic clouds. It is hypothesized that when convection is forced by island surface heating, aerosols from the mostly forested island surface are lofted into the clouds, resulting in the observed high concentration of aerosols and the high concentration of small cloud droplets. When trying to understand the impact of these surface-based aerosols on precipitation, however, observed differences in cloud-layer moisture add to the complexity. The WRF Model with the aerosol-aware Thompson microphysics scheme is used to study six idealized scenarios of thermally driven island convection: with and without a surface aerosol source, with a relatively dry cloud layer and with a moist cloud layer, and with no wind and with a weak background wind. It is found that at least a weak background wind is needed to ensure Dominica-relevant results and that the effect of cloud-layer moisture on cloud and precipitation formation dominates over the effect of aerosol. The aerosol impact is limited by the dominance of precipitation formation through accretion. Nevertheless, in order to match observed cloud microphysical properties and precipitation, both a relatively dry cloud layer and a surface aerosol source are needed. The impact of a surface aerosol source on precipitation is strongest when the environment is not conducive to cloud growth.
Connecting Climate Information Producers and Users: Boundary Organization, Knowledge Networks, and Information Brokers at Caribbean Climate Outlook Forums
Authors: Guido Zack , Rountree Valerie , Greene Christina , Gerlak Andrea , Trotman Adrian 
Published: May 2016

Abstract
Boundary organizations, knowledge networks, and information brokers have been suggested as mechanisms that help integrate information into decision-making and enhance interactions between the producers and users of climate information. While these mechanisms have been discussed in many studies in disparate fields of research, there has been little empirical research describing how they relate and support each other within studies on climate services. In this paper, two Caribbean Regional Climate Outlook Forums (CariCOFs) convened in 2014 are studied. CariCOFs facilitate the production of regional seasonal climate information and the dissemination of it to a diverse climate and socioeconomic region. Network analysis, key informant interviews, and small group discussions were used to answer two questions: 1) what are the barriers to using seasonal climate forecasts (SCFs) by CariCOF participants and 2) what are the iterative processes of information exchange that address these barriers? The barriers to using SCF include difficulty in demonstrating the value of the forecast to potential users, difficulty in interpreting and explaining the forecast to others, and challenges associated with the scientific language used in the information. To address these constraints, the convener of the CariCOF acts as a boundary organization by enabling interactions between participants representing diverse sectoral and geographic settings. This develops a network that helps build shared scientific understanding and knowledge about how different sectors experience climate risk. These interactions guide information brokering activities that help individuals communicate and translate climate information to facilitate understanding at local levels.
Suicide in Greece 1992–2012: A time-series analysis
Authors: Papaslanis Theodoros , Kontaxakis Vassilis , Christodoulou Christos , Konstantakopoulos George , Kontaxaki Maria-Irini , Papadimitriou George N 
Published: May 2016

Background and aims: Since 2008, Greece has entered a long period of economic crisis with adverse effects on various aspects of daily life. In this frame, it is quite important to examine the suicide trends in Greece. Method: Our analysis covered the period 1992–2012. 2012 was the last year for which official suicide data were available. The inclusion of data for pre-crisis period enabled us to assess trends in suicide preceding the economic crisis, starting in 2008. Trends in sex- and age-adjusted standardized suicide rates (SSR) were analyzed using joinpoint regression. Results: Total SSR presented statistically significant annual decrease of 0.89% (95% confidence interval (CI): −1.7, −0.1) during the period 1992–2008. After 2009, the trend in total SSR increased statistically significant annual increase (12.48%; 95% CI: 0.3%, 26.1%). SSR in males presented an initial period of modest annual decrease (−0.84%; 95% CI: −1.6%, −0.1%), during the period 1992–2008. After 2009, an annual increase by 9.25% (95% CI: 2.7%, 16.3%) was revealed. No change in female SSR trend was observed during the studied period. Conclusion: According to the results of this study, there is clear evidence of an increase in the overall SSR and male SSR in Greece during the period of the current financial crisis.
Rates of Mental Illness and Addiction among High-Cost Users of Medical Services in Ontario
Authors: Hensel Jennifer M. , Taylor Valerie H. , Fung Kinwah , Vigod Simone N. 
Published: May 2016

Objective: To quantify the burden of mental illness and addiction among high-costing users of medical services (HCUs) using population-level data from Ontario, and compare to a referent group of nonusers. Method: We conducted a population-level cohort study using health administrative data from fiscal year 2011-2012 for all Ontarians with valid health insurance as of April 1, 2011 ( N = 10,909,351). Individuals were grouped based on medical costs for hospital, emergency, home, complex continuing, and rehabilitation care in 2011-2012: top 1%, top 2% to 5%, top 6% to 50%, bottom 50%, and a zero-cost nonuser group. The rate of diagnosed psychotic, major mood, and substance use disorders in each group was compared to the zero-cost referent group with adjusted odds ratios (AORs) for age, sex, and socioeconomic status. A sensitivity analysis included anxiety and other disorders. Results: Mental illness and addiction rates increased across cost groups affecting 17.0% of the top 1% of users versus 5.7% of the zero-cost group (AOR, 3.70; 95% confidence interval [CI], 3.59 to 3.81). This finding was most pronounced for psychotic disorders (3.7% vs. 0.7%; AOR, 5.07; 95% CI, 4.77 to 5.38) and persisted for mood disorders (10.0% vs. 3.3%; AOR, 3.52; 95% CI, 3.39 to 3.66) and substance use disorders (7.0% vs. 2.3%; AOR, 3.82; 95% CI, 3.66 to 3.99). When anxiety and other disorders were included, the rate of mental illness was 39.3% in the top 1% compared to 21.3% (AOR, 2.39; 95% CI, 2.34 to 2.45). Conclusions: A high burden of mental illness and addiction among HCUs warrants its consideration in the design and delivery of services targeting HCUs.
Australian Trade Liberalisation Policy: The Industries Assistance Commission and the Productivity Commission
Authors: Jones Evan 
Published: May 2016

AbstractThe Productivity Commission is Australia’s foremost policy advisory body. Its original incarnation as the Industries Assistance Commission derives from the 1960s push to dismantle the protective tariff regime that underpinned the Australian manufacturing sector. With success in tariff reductions and complementary reductions in rural sector assistance, the Commission’s investigatory role was gradually expanded to cover the entire gamut of government policy. The Commission’s history has generally been treated favourably. This article places the history of the original Industries Assistance Commission in context and takes a critical stance on its and the Productivity Commission’s vision and achievements.
Correlation of Systemic Inflammatory Markers With Radiographic Stages of Charcot Osteoarthropathy
Authors: Hingsammer Andreas M. , Bauer David , Renner Niklas , Borbas Paul , Boeni Thomas , Berli Martin 
Published: May 2016

Background: Charcot osteoarthropathy (COA) is characterized by a progressive destruction of bone and joint associated with neuropathy and is most common in the foot and ankle. Clinical manifestation of COA is frequently indistinguishable from other causes of pain, swelling, and erythema of the affected extremity, in particular, infection. Diagnosis of COA can be challenging in particular in early stages where radiographic changes are sparse. The presence of elevated systemic inflammatory parameters in the context of suspected infection may delay early diagnosis and treatment of COA. The aim of this retrospective analysis was to assess whether elevated systemic inflammatory parameters may be present, in particular in early stages of COA and thus not be used as an exclusion criterion for the diagnosis of COA. Methods: Forty-two patients (mean age 48.2 ± 9.4 years, 36 male, 6 female) with a diagnosis of unilateral COA were the subject of this retrospective study. The diagnosis of COA was confirmed by plain radiographs, magnetic resonance imaging and clinical course. Systemic inflammatory parameters were recorded at the time of referral. Acute stages (stages 0 and 1) were treated with a total contact cast (TCC) and protected weight bearing for a minimum of 6 weeks. For chronic stages (stages 2 and 3) custom-made shoes were prescribed. The feet were stratified into “acute” (Eichenholz stages 0 and 1) and “subacute/chronic” (Eichenholz stages 2 and 3) groups. Results: Statistically significant differences were observed for all recorded systemic inflammatory parameters (C-reactive protein level, WBC count, erythrocyte sedimentation rate) between the acute and subacute/chronic groups. No statistical difference was observed considering the anatomic pattern of involvement. Conclusion: The present study demonstrated that elevated systemic inflammatory parameters may be present in COA and can further be used to distinguish between acute and subacute stages of COA, based on the Eichenholtz classification. Thus, we suggest that elevated inflammatory markers should not be considered an exclusion criterion for the diagnosis of COA. Level of Evidence: Level III, retrospective comparative series.
Efficacy and Bleeding Risk of Antithrombin Supplementation in Patients With Septic Disseminated Intravascular Coagulation: A Third Survey
Authors: Iba Toshiaki , Gando Satoshi , Saitoh Daizoh , Ikeda Toshiaki , Anan Hideaki , Oda Shigeto , Kitamura Nobuya , Mori Shigeru , Kotani Joji , Kuroda Yasuhiro 
Published: May 2016

Introduction: Although recent studies have reported the efficacy of antithrombin (AT) supplementation for sepsis-associated disseminated intravascular coagulation (DIC), the factors that influence AT’s effect have not been sufficiently studied. The purpose of this survey was to identify factors that modulate the effects and the adverse effects of AT. Methods: We performed a multi-institutional survey. The data from 159 patients with septic DIC with AT ≤70% and who had undergone AT supplementation were analyzed. The patients’ demographic characteristics, including the infection site, baseline sepsis-related organ failure assessment (SOFA) score, baseline DIC score, and baseline AT activity, were analyzed in relation to the 28-day mortality. Bleeding-related adverse events were also examined. Results: Overall, 116 patients survived and 43 did not (28-day mortality: 27.0%). A logistic regression analysis revealed that the baseline SOFA score (odds ratio [OR]: 0.816, P = .001), coadministration of recombinant thrombomodulin (rTM; OR: 3.989, P = .006), and respiratory tract infection (OR: 0.129, P = .000) were significantly associated with the survival. Survivors exhibited a higher peak AT activity than nonsurvivors (85.1% vs 65.0%, P = .027). Bleeding events were observed in 4.13% (major bleeding: 1.65%) of the patients, and the coadministration of rTM did not increase the risk of bleeding (with rTM: 4.11% vs without rTM: 4.17%). Heparin was concomitantly used in 22 (18.2%) cases, and its use nonsignificantly increased the bleeding risk (with heparins: 9.09% vs without heparins: 3.03%; P = .224). Conclusion: The coadministration of rTM may improve survival without increasing the risk of bleeding in patients with sepsis-associated DIC treated with AT.
Enhancing Experience-Driven Leadership Development
Authors: Hezlett Sarah A. 
Published: May 2016

The Problem The notion that a high proportion of leadership development should be the result of learning from experience has become popular, increasing the need for human resource development (HRD) professionals to understand experience-driven leadership development in order to design systems and processes that facilitate it. Relevant research on the topic has been increasing. Although this has improved the opportunity to build evidence-based practice, it also has created the challenge of identifying and digesting key concepts and findings. In addition, there are important misunderstandings regarding experience-driven development and core areas where additional information is needed. The Solution This article synthesizes recent research related to the emerging practice of experience-driven leadership development, using a question and answer format. As a result, key concepts and relevant research results about experience-driven leadership development are summarized in an action-oriented framework. Gaps in knowledge are highlighted and recommendations for future research are offered. The Stakeholders This article will be of particular relevance to scientists pursuing research on experience-driven development and HRD practitioners responsible for improving leadership development, particularly those interested in driving learning through experience.
The Endovascular Preprocedural Run Through and Brief: A Simple Intervention to Reduce Radiation Dose and Contrast Load in Endovascular Aneurysm Repair
Authors: Stansfield Tim , Parker Richard , Masson Neil , Lewis David 
Published: May 2016

Objectives: To assess the impact of a quality assured planning and sizing process and the endovascular team briefing (preprocedure run through and brief – PRTB) on the delivery of endovascular aneurysm repair (EVAR), in Edinburgh. Design: Prospective observational study, comparing parameters before and after the intervention. Materials: Prospectively collected database recording infrarenal aneurysms treated with EVAR performed from January 2007 to April 2014 at our institution. The total screening time, iodinated contrast volume used, radiation dose, endovascular training opportunities, and hospital length of stay were recorded. Methods: A comparison before (January 2007 to November 2011) and after (December 2011 to April 2014) the introduction of the PRTB was made for each of these variables. Multiple linear regression analysis was performed to account for the learning effect. Results: In this study, 61 EVAR cases were performed prior to and 44 EVAR cases after the introduction of the PRTB. Univariate Mann-Whitney tests suggested a significant difference between before PRTB introduction and after PRTB introduction on all outcome variables except procedure time. Multiple linear regression analysis results showed a statistically significant improvement in outcomes after the change point for all outcomes except for radiation dose. Endovascular training opportunities were realized in 12/61 (20%) before compared to 42/44 cases (95%) after PRTB introduction. Conclusions: By introducing rigorous quality assurance and utilizing the principles of crew resource management to the EVAR process, it is possible to reduce screening times, contrast use, hospital length of stay, and improve endovascular training opportunities.
The medical response to the Boston Marathon bombings: an analysis of social media commentary and professional opinion
Authors: Côté Emilie , Hearn Russell 
Published: May 2016

Objectives: To explore the differences in perception of the medical response to the victims of the 2013 Boston Marathon bombings between laypeople and healthcare professionals. Methods: Commentary accessible and available on Internet discussion websites by non-medically trained persons and in the academic literature by healthcare professionals was analysed qualitatively. Results: Major themes were found relating to both the pre-hospital and hospital-based phases of the medical response to the disaster. Laypeople focused more on pre-hospital care and the actions of specific bystanders, while healthcare professionals focused on hospital care, the importance of a disaster plan, and frequent training for the success of the response. Conclusion: Laypeople and healthcare professionals have positive but differing perceptions of the medical response to the victims of the bombings. This may have implications for future funding and implementation of disaster preparedness.