bluuebunny/crossref_metadata_2025_split huggingface dataset:
A composite pressure relief method based on roof cutting and fracturing expansion for thick hard roof in large mining height
Authors: Yang Jun , Song Hongxu , Fu Qiang , Liu Jianning , Gao Yubing , Liu Yuxuan , Jin Hongyu 
Published: September 2024

Abstract

In coal mining, thick and hard roof strata are widely distributed, posing significant hazards that easily lead to various issues such as extensive deformations of the surrounding rock and failure of support systems due to strong mining pressure, resulting in frequent safety incidents. Particularly under conditions of large mining heights, the goaf height increases, exacerbating the problem of strong mining pressure on thick and hard roof strata. To address this issue, this paper proposes a composite pressure relief method (CPRM) based on roof cutting and fracturing expansion for thick hard roof in large mining height. Through theoretical analysis, numerical simulation, and field testing, the pressure relief mechanism and effects of this method are analyzed, validating its efficacy. Research results indicate that the CPRM severs the hanging roof of thick and hard strata, promoting the timely collapse of the roof in the goaf while enhancing the fracturing and expansion filling effect. This effectively reduces the stress intensity in stopes with thick and hard roof strata at high mining heights, significantly addressing issues such as extensive deformation of surrounding rock in roadways caused by strong mining pressure. It provides a reference for pressure relief and control of surrounding rock under similar conditions.
Causal Links of Factors to Neurodegenerative Diseases and Alzheimer's Risk Prediction Model
Authors: Tian Yucheng , Qiu Dan , Wang Zhaowei , Song Renjie , Chen Feiyu , Cheng Xue , Sun Dongqing , Cai Zhijian , Somjit Nutapong , Zhang Weijia 
Published: September 2024

Abstract

Objective: This study aimed to explore the causal links between various lifestyle, demographic, cognitive factors and neurodegenerative diseases, and to develop an Alzheimer's disease (AD) risk prediction model.
Methods: Mendelian randomization analysis was conducted using genetic variants as instrumental variables to investigate the relationships between lifestyle, demographics, cognitive factors, and neurodegenerative diseases. We used the MR-Egger regression, weighted median method, Inverse Variance Weighting (IVW), and weighted model. Based on the Mendelian analysis results, logistic multivariate analysis was used for validation and to design an AD rating prediction model.
Results: Mendelian randomization analysis showed that beer intake was positively correlated with AD risk, whereas education level and cognitive ability were negatively correlated with AD risk. There was a positive correlation between education level, economic status, and risk of Parkinson's. There was a positive correlation between physical activity level and the risk of developing amyotrophic lateral sclerosis, and higher education level is significantly associated with a reduced risk of ALS. Logistic regression analysis showed that age and sex were positively correlated with AD, while education level was negatively correlated with AD. The accuracy of the AD risk prediction model was 78%, which was better than that of the logical model 62%.
Conclusion: Mendelian analysis results indicated that there is a causal relationship between beer intake, educational level, cognitive ability and AD. There is a causal relationship between education level, economic status, and Parkinson's disease. There was a causal relationship between physical activity level, education level, and amyotrophic lateral sclerosis. No causal relationship was found between these factors and Lewy body dementia or frontotemporal dementia. The rating prediction model outperformed traditional logistic models in terms of accuracy .
Associations of furan exposure with the prevalence and mortality in asthma: A prospective cohort study
Authors: Zhang Shuwen , Shen Kunlu , Sun Bingqing , Liu Bowen , Li Chunxiao , Zhou Mengqi , Hou Xin , Xiang Min , Lin Jiangtao 
Published: September 2024

Abstract

Background
Few studies have explored the role of furan exposure plays in aggravating asthma.
Objective
To access the relationship of furan exposure to asthma.
Methods
This is a prospective cohort study, involving 7,047 adults over 20 years old from the National Health and Nutrition Examination Survey 2007–2012. Blood furan levels were employed to quantify furan exposure. Multivariate survey-weighted regressions were utilized to analyze the associations between furan exposure, the prevalence of asthma. Mediation analyses for furan exposure and asthma prevalence were conducted. Multiple Cox regression was employed to evaluate the association between furan exposure and asthma prognosis.
Results
Asthmatics have higher blood furan levels than non-asthmatics (P < 0.001). After adjusting for covariates, log10-transformed blood furan levels (LBFL) were independently associated with an increased risk of asthma prevalence (adjusted odds ratio [aOR] = 2.40, 95% confidence interval [CI] = 1.21–4.78, P = 0.014). There was a significant positive linear relationship between LBFL and risk of asthma (P for linear = 0.0003). In mediation analyses, FEV1 was identified as mediators in the above relationships, with mediated proportions of 32.73%. Longitudinally, multiple Cox regression analysis demonstrated that LBFL were positively correlated with respiratory mortality in asthma (HR = 27.88, 95% CI = 4.19-185.69, P < 0.0001).
Conclusions
Exposure to furan revealed a positive association with greater odds of asthma, and lung function was identified as an important mediator. An elevated LBFL also is associated with an increased health care use, worse HQL, and prognosis of asthma.
Densification and resistance of Ta 2 O 5 and ZnO co-doped SnO 2 ceramic targets for low-cost TCO films of solar cells
Authors: Jian Ning , Xu Jiwen , Zhu Guisheng , Shang Fei , Xu Huarui 
Published: September 2024

Abstract

Low cost transparent and conducting oxide (TCO) films are important for solar cells, and sintering densification of SnO2-based ceramic targets for depositing TCO film are difficult. Ta2O5 and ZnO were used as dopants and harmless sintering aid, respectively. The targets with different ZnO contents show single rutile structure. The sintering densification was improved by ZnO, and the dense microstructure has fine grains with an average size of 0.2-3 µm. The decomposition and volatilization of targets sintered at higher temperature decrease density. The 0.85 wt% ZnO doped target at the optimal sintering temperature of 1500°C obtain the highest relative density (> 99%) and low resistance (< 50 Ω). The enhanced density of SnO2-based targets by ZnO can effectively improve the density, and further inhibit the formation of nodules on the target surface during magnetron sputtering.
An investigation into the seasonal, herd-specific, parity, and subclinical mastitis-related fluctuations in the microflora of raw milk from dairy cows in Ningxia, China
Authors: xie xiulan 
Published: September 2024

Abstract

Background
The milk microflora is closely associated with the physiology and pathology of the mammary gland, and plays a pivotal role in the development of offspring. The aim of this study was to examine the variability of milk microflora diversity in relation to seasonal, herd-specific, subclinical mastitis status, and parity-related effects.
Results
Milk samples were collected from 285 cows in Ningxia, China, followed by the exploration of microflora using 16S rRNA pyrosequencing. Subsequently, all samples were categorized based on seasonal variations (summer and winter), cow health status (healthy and subclinical mastitis cows), farm origins (6 commercial dairy farms), and parity levels (primiparity and multiparity). The bacterial diversity, community composition, and abundance were assessed in distinct cohorts. Additionally, the milk microflora from samples collected during summer, winter, and colostrum was compared. The findings indicated a significant variation in the bacterial diversity of milk between samples collected from summer and winter. It was observed that the summer samples exhibited higher bacterial richness compared to the winter samples. The gut-related genera, including Parabacteroides, Staphylococcus, Corynebacterium_1, Sphingomonas, and Lactobacillus, were found to be prevalent in milk samples collected in summer. Conversely, Escherichia_Shigella, Pseudomonas, Streptococcus, Psychrobacter, Rhizobium, Bifidobacterium, and Clostridium_sensu_stricto_1 were commonly observed in winter samples. The subclinical mastitis cows showed a significantly higher alpha diversity value (chao1 and Shannon index) compared to the healthy cows (summer). Sporolactobacillus, Mycobacterium, Escherichia_Shigella, and Actionmycetaceae were identified as biomarkers in the subclinical mastitis cows. In addition, the top 20 KEGG pathways were significantly reduced in the subclinical mastitis group compared to the healthy cows in summer, particularly in membrane transport, cell motility, and signal transduction pathways. The bacterial diversity varied across different farms, with Farms A and B demonstrating a higher degree of similarity of milk bacterial composition, while Farms D and F also displayed similarities. Farm C appeared distinct from other farms. Furthermore, there was observed a greater bacterial richness in multiparous cows compared to primiparous cows. Additionally, the comparative analysis revealed a significant difference in alpha and beta diversity, bacterial profiles among summer, winter and colostrum samples.
Conclusions
The study indicated that the composition of milk microflora exhibited variability across different seasons, farms, healthy status, and parities. Furthermore, distinct microflora characteristics were observed in milk samples obtained during summer, winter, and colostrum stages.
Guanidine hydrochloride assisted one-pot synthesis of 2-amino-4,6- disubstituted-3-cyanopyridine derivatives: a sustainable and greener strategy with catalyst recyclability
Authors: Yadav Pradeep U. , Zade Vivek D. , Gadkari Yatin U. 
Published: September 2024

Abstract

Here, we highlight an efficient and novel approach for the one-pot multicomponent preparations of 2-amino-4,6-disubstituted-3-cyanopyridine derivatives through the cyclo-condensation of substituted aromatic aldehydes, ammonium acetate, malononitrile, and aryl ketones under neat conditions. This study presents a novel approach for the preparations of 2-amino-4,6-disubstituted-3-cyanopyridine derivatives with numerous advantages, such as rapid reaction, environmentally friendly conditions, a broad range of compatible substrates, catalyst recyclability, and a simple workup process. The reported method harnesses the catalytic potential of guanidine hydrochloride, serving as a highly effective organo-catalyst, which exhibits exceptional mildness and catalytic activity, facilitating the reaction with high yield.
Enhanced Movie Recommendation Systems: Integrating Improved Kernel Self-Organizing Maps and Silhouette Analysis
Authors: Sharma Saurabh , Dubey Ghanshyam Prasad , Shakya Harish Kumar 
Published: September 2024

Abstract

The field of movie recommendation systems faces significant obstacles in achieving high accuracy and relevance, primarily due to issues such as cluster overlap and data integration. This work introduces a novel strategy that combines the Improved Kernel Self-organising Map (IKSOM) and Silhouette Clustering methods to address these challenges. The IKSOM algorithm enhances the accuracy of movie recommendations by improving the representation of user and item information in a high-dimensional space. The technique of Silhouette Clustering is utilised to improve the definition of cluster boundaries and minimise the occurrence of overlapping among clusters of movies. The methodology involves combining many data sources through data fusion techniques to improve the recommendation process by including contextual and user-specific information. By incorporating these techniques, the proposed strategy not only improves the precision and comprehensiveness of suggestions but also effectively reduces the duplication among groups, leading to a greater variety of relevant and suitable movie selections. The performance assessment of the proposed system was conducted using the MovieLens_25M dataset. The findings demonstrate a significant improvement in the accuracy of recommendations, with the system achieving an accuracy rate of 98.2%, a precision rate of 96.6%, a recall rate of 95.2%, an F1-score of 95.4%, a Root Mean Square Error (RMSE) of 0.462, and a Mean Absolute Error (MAE) of 0.243. These indicators illustrate the efficacy of the integrated strategy in delivering recommendations of superior quality. This research provides a comprehensive analysis of the potential enhancements that can be achieved in movie recommendation systems through the merging of IKSOM and Silhouette Clustering techniques. The findings suggest that combining advanced clustering methods with reliable data fusion techniques can significantly improve recommendation performance and increase user satisfaction. Future study should explore the integration of contextual variables and current information to improve the adaptability and precision of recommendation systems.
Corrosion-enhanced activated carbon deodorization of malodorous gases from fish processing
Authors: Wysocka Izabela , Lipińska Anna 
Published: September 2024

Abstract

Activated carbon adsorption is one of the most effective methods of deodorizing malodorous gases generated by fish processing. This paper proposes an innovative method of improving activated carbon adsorption of malodorous gases from the fish industry. The solution, which involves introducing a layer of corroding steel packing into the adsorption bed, provided the same high deodorization rate as activated carbon alone (nearly 100%). The innovation considerably extended the adsorbent service life. For gases with a concentration of 2,200 ouE/m3, the efficiency of the activated carbon increases over ninefold. At a carbon price of 2,400 € per ton, gas treatment becomes considerably cheaper (a reduction of 3.59 € per 1 m3 treated gas, which translates to a final cost of 0.38 €). The steel packing can consist of recycled materials. If the corrosivity of the treated gases is similar to that of air, the packing can be reused repeatedly, even over dozens of years.
Cyclopogon Guayanensis is an Unusual Orchid With a Generalistic Pollination System and Hexose Dominant Nectar
Authors: MENEGUZZO THIAGO E. C. , GOMES SUELI M. , BATISTA JOÃO A. N. , AGUIAR ANTONIO J. C. , MARTINS ALINE C. , WILLIAMS THOMAS C. R. , PROENÇA CAROLYN E. B. 
Published: September 2024

Abstract

Cyclopogon is a large Neotropical orchid genus pollinated by halictid bees that offers nectar as reward. In a recent phylogenetic tree, Brachystele guayanensis emerged nested within Cyclopogon and was transferred to that genus. The hypothesis for this study was that C. guayanensis would show a similar floral biology to Cyclopogon, although distinctive in its small, congested white flowers. Data on floral biology, pollinators, micromorphology, histochemistry, and nectar sugar composition of C. guayanensis in the Distrito Federal, Brazil were gathered. C. guayanensis is pollinated by at least four species of bees belonging to genera Exomalopsis, Nomada, Tetrapedia (Apidae) and Dialictus (Halictidae) foraging for nectar. Nectar is produced in visually imperceptible quantities by papillae on the inner surface of the labellum; similar papillae occur in other species of Cyclopogon but nectar class is unknown. C. guayanensis nectar is hexose dominant (< 10% sucrose) in the Baker and Baker system and is the second record of this nectar class in the Orchidaceae. Pollinia are dorsally adhesive and probably attach to the underside of the bee labrum, as in other Cyclopogon. The inflorescence rachis, bracteoles, and outer surfaces of the base of the sepals are covered with lipid-secreting glandular trichomes; sepals and petals have numerous raphid-rich idioblasts. This is the first record of papillae on a spurless labellum shown to produce nectar in the Orchidoideae. We suggest that hexose dominant nectars in the Orchidaceae are associated with a geophytic habit, small pale flowers, exposed nectaries, visually imperceptible quantities of nectar, and a generalistic pollination system, and coin the term ‘modest pollination strategy’ for this syndrome.
Hospital mortality and associated factors of Road traffic accident victims admitted at the trauma centers in Ethiopia. Hospital based retrospective cross- sectional study
Authors: Samuel Abraham , Hussien Heyira , Engida Haywet , Lajore Bereket Aberham , Moges Sisay , Lodebo Mengistu , Mekebo Merkineh 
Published: September 2024

Abstract

Background
About 1.35 million peoples deceased every year as a consequence of road traffic accidents (RTA). Half of all road traffic deaths occur among susceptible road users: walkers, bikers, and racers. 93% of the world's mortalities on the streets occur in low- and middle-income countries (LMICs), although these nations have a small number of the world's vehicles. Ethiopia is a country with small number of vehicles and large number of death due to road traffic accident. This study aimed to assess mortality among admitted road traffic accident victims and factors determining it.
Methods
The study was conducted in Addis Ababa Burn and emergency trauma (AaBET), and Tikur Anbessa specialized hospital (TASH) in Addis Ababa, Ethiopia from March 13, 2021 to April 23, 2021. Hospital-based retrospective cross-sectional chart review methods were implemented from Dec 31st 2018 to January 1st, 2021. 398 RTA victims were selected using simple random sampling method. Structured checklist was used to collect the data. The collected data was cleaned and entered into Epi-data ver.4.6 and exported to SPSS ver.26 for analysis. Binary logistic regression analyses were used to determine the association between variables.
Result
The study found that hospital mortality of road traffic accident victims admitted at AaBET and TASH in AA, Ethiopia, were 31.6% during the last two years. Among RTA victims who had severe head injury was more than 30 times (AOR = 30.79, 95%CL: 6.62, 143.25) likely to cause hospital mortality as compared to those who had a mild head injury. The hospital fatality of RTA victims who were admitted for ≥ 1 day more than 24 times (AOR = 24.88, 95%CI: 5.13, 114.37) likely to die as compared to those who had a length of hospital stay > 3days.
Conclusion and Recommendation:
This research clearly illustrates that the hospital mortality of RTA in the last 3 years was found to be high. The study revealed that head injury state severity, endotracheal intubation status, and length of hospital stay significantly determined hospital mortality of road traffic accidents.
Exploring the Anticonvulsant Potential of Agmatine in a Rotenone-Induced Corneal Kindling Mice Model of Drug-Resistant Epilepsy: The Dual Control of Neurochemical Aberrations and Oxidative Stress
Authors: Kaur Rashmin , Kaur Arvinder , Kaur Arshbir , Goel R. K 
Published: September 2024

Abstract

Objective
The study aimed to investigate the ameliorative potential of Agmatine in mitochondrial drug-resistant epilepsy (DRE) owing to its ability to maintain neurochemical homeostasis and antioxidant effect.
Material and Method:
Adult albino mice(n = 42) were subjected to rotenone corneal kindling (2.5 mg/kg i.p.) with daily electric shocks (15 mA, 20V, 6Hz for 3s) via corneal electrode to develop mitochondrial DRE. The pre-treatment validation was carried using five standard ASDs (Pregabalin, Levetiracetam, Carbamazepine, Lamotrigine, and Phenytoin). Thereafter, animals were divided into six groups (excluding naïve): one control, and others received Agmatine (Agm) (5, 10 mg/kg i.p.) and Valproate (Val) (300 mg/kg i.p.) individually and in combination. The post-treatment resistance validation was conducted with same ASDs in same order following treatment phase. Further, the neurochemical (agmatine, arginine, GABA, glutamate, serotonin, and norepinephrine) and biochemical (GSH, Catalase, and TBARS) milieu were assessed in cortex and hippocampus regions of brain.
Results
The inability to reduce seizure severity by standard ASDs after 15-day kindling procedure, confirms the development of drugs resistance. Agmatine effectively eliminated resistance as post-treatment ASDs administration following the treatment phase as revealed by decreased in seizure severity scores. It also showed neurochemical modulatory activity as evidenced by elevated levels of agmatine, arginine, GABA, serotonin, norepinephrine and reduced glutamate levels and antioxidant activity by showing raised levels of GSH, catalase and lowered TBARS level. More Significant outcomes were found with combination of Agm 10 mg/kg and valproate 300 mg/kg
Conclusion
The present study revealed the reversal of drugs resistance in rotenone model of DRE by agmatine through its neurochemical modulatory and anti-oxidant property.
An aging-sensitive compensatory secretory phospholipase that confers neuroprotection and cognitive resilience
Authors: Sahay Amar , Vicidomini Cinzia , Goode Travis , McAvoy Kathleen , Yu Ruilin , Beveridge Conor , Iyer Sanjay , Victor Matheus , Leary Noelle , Steinbaugh Michael , Lai Zon , Lyon Marina , Silvestre Manuel , Bonilla Gracia , Sadreyev Ruslan , Walther Tobias , Sui Shannan , Saido Takaomi , Yamamoto Kei , Murakami Makoto , Tsai Li-Huei , Chopra Gaurav , Evans Liam 
Published: September 2024

Abstract

Breakdown of lipid homeostasis is thought to contribute to pathological aging, the largest risk factor for neurodegenerative disorders such as Alzheimer’s Disease (AD). Cognitive reserve theory posits a role for compensatory mechanisms in the aging brain in preserving neuronal circuit functions, staving off cognitive decline, and mitigating risk for AD. However, the identities of such mechanisms have remained elusive. A screen for hippocampal dentate granule cell (DGC) synapse loss-induced factors identified a secreted phospholipase, Pla2g2f, whose expression increases in DGCs during aging. Pla2g2f deletion in DGCs exacerbates aging-associated pathophysiological changes including synapse loss, inflammatory microglia, reactive astrogliosis, impaired neurogenesis, lipid dysregulation and hippocampal-dependent memory loss. Conversely, boosting Pla2g2f in DGCs during aging is sufficient to preserve synapses, reduce inflammatory microglia and reactive gliosis, prevent hippocampal-dependent memory impairment and modify trajectory of cognitive decline. Ex vivo, neuronal-PLA2G2F mediates intercellular signaling to decrease lipid droplet burden in microglia. Boosting Pla2g2f expression in DGCs of an aging-sensitive AD model reduces amyloid load and improves memory. Our findings implicate PLA2G2F as a compensatory neuroprotective factor that maintains lipid homeostasis to counteract aging-associated cognitive decline.