bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Zhoujiatai Occult Manuscripts (周家臺的數術簡)
Authors: Harper (夏德安) Donald 
Published: October 2017

Bamboo-slip manuscripts from Zhoujiatai tomb 30, Hubei (burial dated ca. 209 b.c.e.), provide important evidence of ancient Chinese occult manuscripts belonging to a man of modest status. One manuscript, identified as a rishu “day book” by the modern editors of the Zhoujiatai manuscripts, treats of hemerology and astrology and is the focus of this study. The bamboo slips of a calendar for years corresponding to 211–210 b.c.e. can be associated with the rishu and may have formed one manuscript unit. The contents of the rishu include two large-size diagrams related to hemerological and astro-calendrical systems. The first diagram involves calculations based on the position of the handle of the Dipper constellation and the second diagram is notable for reference to one of the years (211 b.c.e.) of the associated calendar. A third diagram, for which the title rong liri “rong calendar day [divination]” is written on the manuscript, has a slightly different form in a second occurrence on the manuscript. Both forms of the diagram show thirty lines arranged in a vertical column, corresponding to the thirty days of the ideal month, with some lines enclosed in boxes. Days of the month are counted in the sequence of lines on the diagram in order to determine the lucky and unlucky aspects of a given day. A related hemerological system is attested in a manuscript from Mawangdui tomb 3, Hunan (burial dated 168 b.c.e.), and in medieval occult manuscripts from Dunhuang.
湖北省周家臺30號墓簡(約公元前209年)提供了關於古代中國一名低級官吏所擁有的數術簡的寶貴資料。本文主要研究其中由整理者认定为《日書》的簡文及其涉及的擇日、星象等內容。同墓出土的暦譜(公元前211–210年)與《日書》相關,可能本來屬於同一卷簡冊。《日書》包括兩幅大圖,一個與擇日有關,一個與星象曆法體系有關。第一圖講基於北斗七星斗柄指向的算法,第二圖因爲涉及到暦譜記載公元前211年的內容而受到矚目。另外第三幅圖簡文記述其名曰“戎磿日”,存在兩個稍微不同的版本。兩個版本的圖都是由縱向排列的三十條橫綫構成,代表一个月的理想天数三十,並和周圍的綫條組成方框。按照圖中橫綫的順序判斷每個月中相應的那一天是否吉利。與此相關的擇日法也在湖南馬王堆3號墓(約公元前168年)與中古時期敦煌的數術文獻中出現。
Turbulent Heat Fluxes during an Extreme Lake-Effect Snow Event
Authors: Fujisaki-Manome Ayumi , Fitzpatrick Lindsay E. , Gronewold Andrew D. , Anderson Eric J. , Lofgren Brent M. , Spence Christopher , Chen Jiquan , Shao Changliang , Wright David M. , Xiao Chuliang 
Published: October 2017

Abstract
Proper modeling of the turbulent heat fluxes over lakes is critical for accurate predictions of lake-effect snowfall (LES). However, model evaluation of such a process has not been possible because of the lack of direct flux measurements over lakes. The authors conducted the first-ever comparison of the turbulent latent and sensible heat fluxes between state-of-the-art numerical models and direct flux measurements over Lake Erie, focusing on a record LES event in southwest New York in November 2014. The model suite consisted of numerical models that were operationally and experimentally used to provide nowcasts and forecasts of weather and lake conditions. The models captured the rise of the observed turbulent heat fluxes, while the peak values varied significantly. This variation resulted in an increased spread of simulated lake temperature and cumulative evaporation as the representation of the model uncertainty. The water budget analysis of the atmospheric model results showed that the majority of the moisture during this event came from lake evaporation rather than a larger synoptic system. The unstructured-grid Finite-Volume Community Ocean Model (FVCOM) simulations, especially those using the Coupled Ocean–Atmosphere Response Experiment (COARE)-Met Flux algorithm, presented better agreement with the observed fluxes likely due to the model’s capability in representing the detailed spatial patterns of the turbulent heat fluxes and the COARE algorithm’s more realistic treatment of the surface boundary layer than those in the other models.
Nonlinear Least Squares En4DVar to 4DEnVar Methods for Data Assimilation: Formulation, Analysis, and Preliminary Evaluation
Authors: Tian Xiangjun , Zhang Hongqin , Feng Xiaobing , Xie Yuanfu 
Published: October 2017

Abstract
The En4DVar method is designed to combine the flow-dependent statistical covariance information of EnKF into the traditional 4DVar method. However, the En4DVar method is still hampered by its strong dependence on the adjoint model of the underlying forecast model and by its complexity, maintenance requirements, and the high cost of computer implementation and simulation. The primary goal of this paper is to propose an alternative approach to overcome the main difficulty of the En4DVar method caused by the use of adjoint models. The proposed approach, the nonlinear least squares En4DVar (NLS-En4DVar) method, begins with rewriting the standard En4DVar formulation into a nonlinear least squares problem, which is followed by solving the resulting NLS problem by a Gauss–Newton iterative method. To reduce the computational and implementation complexity of the proposed NLS-En4DVar method, a few variants of the new method are proposed; these modifications make the model cheaper and easier to use than the full NLS-En4DVar method at the expense of reduced accuracy. Furthermore, an improved iterative method based on the comprehensive analysis on the above NLSi-En4DVar family of methods is also proposed. These proposed NLSi-En4DVar methods provide more flexible choices of the computational capabilities for the broader and more realistic data assimilation problems arising from various applications. The pros and cons of the proposed NLSi-En4DVar family of methods are further examined in the paper and their relationships and performance are also evaluated by several sets of numerical experiments based on the Lorenz-96 model and the Advanced Research WRF (ARW) Model, respectively.
“First Korean Philosophers” on Philosophy
Authors: Kang Young Ahn 
Published: October 2017

AbstractPhilosophy as an academic discipline was introduced to Korea at the end of the 19th century. Philosophical education and professional research did not begin, however, until the 1920s. The first institution in which Koreans could study philosophy as a major at college level was Keijō Imperial University, which was founded by the Japanese in 1924 in Seoul, Korea. The first graduates from this school produced their research in Korean and contributed to the settlement of philosophy on the Korean peninsula. They were joined by Koreans who had returned from study in Austria, Germany, France, and the United States. I call these the “first Korean philosophers.” In order for an individual to belong to this group, three conditions had to be met: first, he or she should have studied philosophy as a major at college level; second, he or she should have read Western philosophical texts in original or in translation; third: he or she should have written a treatise in the contemporary Korean language. Against this background, I am going to deal with three questions. The first question concerns their attitude towards philosophy. The second question concerns their conception of philosophy. The third question concerns the method of doing philosophy. Through this study, I have shown that the first Korean philosophers foreshadowed the struggle between the Marxist and liberal understandings of the world and of humanity, even though they lived in the time of Japanese occupation.
Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells
Authors: Zhao Xin , Gao Shouguo , Wu Zhijie , Kajigaya Sachiko , Feng Xingmin , Liu Qingguo , Townsley Danielle M. , Cooper James , Chen Jinguo , Keyvanfar Keyvan , Fernandez Ibanez Maria del Pilar , Wang Xujing , Young Neal S. 
Published: October 2017

Key Points
We distinguished aneuploid cells from diploid cells within the hematopoietic stem and progenitor cells using scRNA-seq. Monosomy 7 cells showed downregulated pathways involved in immune response and maintenance of DNA stability.
Macrophages and osteoclasts stem from a bipotent progenitor downstream of a macrophage/osteoclast/dendritic cell progenitor
Authors: Xiao Yanling , Palomero Jara , Grabowska Joanna , Wang Liqin , de Rink Iris , van Helvert Luuk , Borst Jannie 
Published: October 2017

Key Points
Under homeostatic conditions, MΦs, OCs, and DCs develop from a tripotent progenitor, the MODP. In mouse bone marrow, we define a novel, bipotent MΦ/OC progenitor, the MOP, that lies downstream of the MODP.
Experimental study of fracture size effect on elastic-wave velocity dispersion and anisotropy
Authors: Shuai Da , Wei Jianxin , Di Bangrang , Yuan Sanyi , Xie Jianyong , Yan Shiqi 
Published: October 2017

We have designed transversely isotropic models containing penny-shaped rubber inclusions, with the crack diameters ranging from 2.5 to 6.2 mm to study the influence of fracture size on seismic velocity under controlled conditions. Three pairs of transducers with different frequencies (0.5, 0.25, and 0.1 MHz) are used for P- and S-wave ultrasonic sounding, respectively. The P-wave measurements indicate that the scattering effect is dominant when the waves propagate perpendicular to the fractures. Our experimental results demonstrate that when the wavelength-to-crack-diameter ratio ([Formula: see text]) is larger than 14, the P-wave velocity can be described predominantly by the effective medium theory. Although the ratio is larger than four, the S-wave velocity is close to the equivalent medium results. When [Formula: see text] < 14 or [Formula: see text] is < 4, the elastic velocity is dominated by scattering. The magnitudes of the Thomsen anisotropic parameters [Formula: see text] and [Formula: see text] are scale and frequency dependent on the assumption that the transversely isotropic models are vertical transversely isotropic medium. Furthermore, we compare the experimental velocities with the Hudson theory. The results illustrate that there is a good agreement between the observed P-wave velocity and the Hudson theory when [Formula: see text] > 7 in the directions parallel and perpendicular to the fractures. For small fracture diameters, however, the P-wave velocity perpendicular to the fractures predicted from the Hudson theory is not accurate. When [Formula: see text] < 4, there is good agreement between the experimental fast S-wave velocity and the Hudson theory, whereas the experimental slow S-wave velocity diverges with the Hudson theory. When [Formula: see text] > 4, the deviation of fast and slow S-wave velocities with the Hudson prediction is stable.
Cancer Center Clinic and Research Team Perceptions of Identity and Interactions
Authors: Reimer Torsten , Lee Simon J. Craddock , Garcia Sandra , Gill Mary , Duncan Tobi , Williams Erin L. , Gerber David E. 
Published: October 2017

Purpose: Conduct of cancer clinical trials requires coordination and cooperation among research and clinic teams. Diffusion of and confusion about responsibility may occur if team members’ perceptions of roles and objectives do not align. These factors are critical to the success of cancer centers but are poorly studied. Methods: We developed a survey adapting components of the Adapted Team Climate Inventory, Measure of Team Identification, and Measure of In-Group Bias. Surveys were administered to research and clinic staff at a National Cancer Institute–designated comprehensive cancer center. Data were analyzed using descriptive statistics, t tests, and analyses of variance. Results: Responses were received from 105 staff (clinic, n = 55; research, n = 50; 61% response rate). Compared with clinic staff, research staff identified more strongly with their own group ( P < .01) but less strongly with the overall cancer center ( P = .02). Both clinic staff and research staff viewed their own group’s goals as clearer than those of the other group ( P < .01) and felt that members of their groups interacted and shared information within ( P < .01) and across ( P < .01) groups more than the other group did. Research staff perceived daily outcomes as more important than did clinic staff ( P = .05), specifically research-related outcomes ( P = .07). Conclusion: Although there are many similarities between clinic and research teams, we also identified key differences, including perceptions of goal clarity and sharing, understanding and alignment with cancer center goals, and importance of outcomes. Future studies should examine how variation in perceptions and group dynamics between clinic and research teams may impact function and processes of cancer care.
Opioid Prescription Trends Among Patients With Cancer Referred to Outpatient Palliative Care Over a 6-Year Period
Authors: Haider Ali , Zhukovsky Donna S. , Meng Yee Choon , Baidoo Joseph , Tanco Kimberson C. , Stewart Holly A. , Edwards Tonya , Joy Manju P. , Kuriakose Leela , Lu Zhanni , Williams Janet L. , Liu Diane D. , Bruera Eduardo 
Published: October 2017

Introduction:In the United States, opioid regulations have become increasingly stringent in recent years. Increased regulatory scrutiny, in part, is related to heightened awareness through literature and a recent media blitz on the opioid prescription epidemic. These regulations have the potential to impact prescription trends by health care providers. Our objective was to evaluate changes in the type and dose of opioid prescriptions among patients who are referred by oncologists to an outpatient palliative care clinic.Materials and Methods:We reviewed the electronic health records of 750 patients who were seen as new consultations at MD Anderson Cancer Center’s outpatient palliative care clinic between January 1 and April 30 each year from 2010 through 2015. Data collected included demographics, cancer type and stage, symptom assessment, performance status, opioid type, and opioid dose defined as the morphine equivalent daily dose (MEDD).Results:Median age was 59 years (interquartile range [IQR], 51 to 67), 383 (51%) were female, 529 (70%) were white, and 654 (87%)of patients had advanced cancer. In 2010, median MEDD before referral was 78 mg/d (IQR, 30 to 150); however, by 2015, the MEDD had progressively decreased to 40 mg/d (IQR, 19 to 80; P = .001). Hydrocodone was the most common opioid prescribed between 2010 and 2015; however, after its reclassification as a schedule II opioid in October 2014, the use of tramadol, a schedule IV opioid, increased ( P < .001).Conclusion:During the past several years, the MEDD prescribed by referring oncologists has decreased. After hydrocodone reclassification, the use of tramadol with less stringent prescription limits has increased.
High Expression of FGD3, a Putative Regulator of Cell Morphology and Motility, Is Prognostic of Favorable Outcome in Multiple Cancers
Authors: Willis Scooter , Sun Yuliang , Abramovitz Mark , Fei Teng , Young Brandon , Lin Xiaoqian , Ni Min , Achua Justin , Regan Meredith M. , Gray Kathryn P. , Gray Robert , Wang Victoria , Long Bradley , Kammler Roswitha , Sparano Joseph A. , Williams Casey , Goldstein Lori J. , Salgado Roberto , Loi Sherene , Pruneri Giancarlo , Viale Giuseppe , Brown Myles , Leyland-Jones Brian 
Published: October 2017

Purpose Identification of single-gene biomarkers that are prognostic of outcome can shed new insights on the molecular mechanisms that drive breast cancer and other cancers. Methods Exploratory analysis of 20,464 single-gene messenger RNAs (mRNAs) in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) discovery cohort indicates that low expression of FGD3 mRNA is prognostic for poor outcome. Prognostic significance of faciogenital dysplasia 3 (FGD3), SUSD3, and other single-gene proliferation markers was evaluated in breast cancer and The Cancer Genome Atlas (TCGA) cohorts. Results A meta-analysis of Cox regression of FGD3 mRNA as a continuous variable for overall survival of estrogen receptor (ER)–positive samples in METABRIC discovery, METABRIC validation, TCGA breast cancer, and Combination Chemotherapy in Treating Women With Breast Cancer (E2197) cohorts resulted in a combined hazard ratio (HR) of 0.69 (95% CI, 0.63 to 0.75), indicating better outcome with high expression. In the ER-negative samples, the combined meta-analysis HR was 0.72 (95% CI, 0.63 to 0.82), suggesting that FGD3 is prognostic regardless of ER status. The potential of FGD3 as a biomarker for freedom from recurrence was evaluated in the Breast International Group 1-98 (BIG 1-98; Letrozole or Tamoxifen in Treating Postmenopausal Women With Breast Cancer) study (HR, 0.85; 95% CI, 0.76 to 0.93) for breast cancer–free interval. In the Hungarian Academy of Science (HAS) breast cancer cohort, splitting on the median had an HR of 0.49 (95% CI, 0.42 to 0.58) for recurrence-free survival. A comparison of the Stouffer P value in five ER-positive cohorts showed that FGD3 ( P = 3.8E-14) outperformed MKI67 ( P = 1.06E-8) and AURKA ( P = 2.61E-5). A comparison of the Stouffer P value in four ER-negative cohorts showed that FGD3 ( P = 3.88E-5) outperformed MKI67 ( P = .477) and AURKA ( P = .820). Conclusion FGD3 was previously shown to inhibit cell migration. FGD3 mRNA is regulated by ESR1 and is associated with favorable outcome in six distinct breast cancer cohorts and four TCGA cancer cohorts. This suggests that FGD3 is an important clinical biomarker.
Role of connexin 43 in different forms of intercellular communication – gap junctions, extracellular vesicles and tunnelling nanotubes
Authors: Ribeiro-Rodrigues Teresa M. , Martins-Marques Tânia , Morel Sandrine , Kwak Brenda R. , Girão Henrique 
Published: October 2017

ABSTRACT
Communication is important to ensure the correct and efficient flow of information, which is required to sustain active social networks. A fine-tuned communication between cells is vital to maintain the homeostasis and function of multicellular or unicellular organisms in a community environment. Although there are different levels of complexity, intercellular communication, in prokaryotes to mammalians, can occur through secreted molecules (either soluble or encapsulated in vesicles), tubular structures connecting close cells or intercellular channels that link the cytoplasm of adjacent cells. In mammals, these different types of communication serve different purposes, may involve distinct factors and are mediated by extracellular vesicles, tunnelling nanotubes or gap junctions. Recent studies have shown that connexin 43 (Cx43, also known as GJA1), a transmembrane protein initially described as a gap junction protein, participates in all these forms of communication; this emphasizes the concept of adopting strategies to maximize the potential of available resources by reutilizing the same factor in different scenarios. In this Review, we provide an overview of the most recent advances regarding the role of Cx43 in intercellular communication mediated by extracellular vesicles, tunnelling nanotubes and gap junctions.
A versatile optical tool for studying synaptic GABAA receptor trafficking
Authors: Lorenz-Guertin Joshua M. , Wilcox Madeleine R. , Zhang Ming , Larsen Mads B. , Pilli Jyotsna , Schmidt Brigitte F. , Bruchez Marcel P. , Johnson Jon W. , Waggoner Alan S. , Watkins Simon C. , Jacob Tija C. 
Published: October 2017

ABSTRACT
Live-cell imaging methods can provide critical real-time receptor trafficking measurements. Here, we describe an optical tool to study synaptic γ-aminobutyric acid (GABA) type A receptor (GABAAR) dynamics through adaptable fluorescent-tracking capabilities. A fluorogen-activating peptide (FAP) was genetically inserted into a GABAAR γ2 subunit tagged with pH-sensitive green fluorescent protein (γ2pHFAP). The FAP selectively binds and activates Malachite Green (MG) dyes that are otherwise non-fluorescent in solution. γ2pHFAP GABAARs are expressed at the cell surface in transfected cortical neurons, form synaptic clusters and do not perturb neuronal development. Electrophysiological studies show γ2pHFAP GABAARs respond to GABA and exhibit positive modulation upon stimulation with the benzodiazepine diazepam. Imaging studies using γ2pHFAP-transfected neurons and MG dyes show time-dependent receptor accumulation into intracellular vesicles, revealing constitutive endosomal and lysosomal trafficking. Simultaneous analysis of synaptic, surface and lysosomal receptors using the γ2pHFAP–MG dye approach reveals enhanced GABAAR turnover following a bicucculine-induced seizure paradigm, a finding not detected by standard surface receptor measurements. To our knowledge, this is the first application of the FAP–MG dye system in neurons, demonstrating the versatility to study nearly all phases of GABAAR trafficking.
Nursing Pain Assessment & Management: A 3D Interactive Simulation
Authors: Romero-Hall Enilda , Watson Ginger S. , Papelis Yiannis , Garcia Hector 
Published: October 2017

In this design case, a team developed a 3D interactive simulation for nursing students and professional nurses to train and practice pain assessment and management procedures. In the simulation environment, the trainees interact with three emotionally expressive animated patients. The three patients vary in their ethnicity, age, and emotion intensity. Successful completion of the scenario requires that the trainee perform of a series of pain assessment and management tasks. The trainee is evaluated on the efficiency and appropriate sequencing of the tasks. The purpose of this paper is to describe the decisions made regarding the type of virtual patients used, the clickable objects, the pain assessment interview protocol, the visual representations in the simulation and the web portal. The paper also provides insight into the processes and steps taken during the design and development phases of this 3D interactive simulation including: the tasks analyses, motion capture, validation of the animations in the simulation, programming, and other tasks.