bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-centered care coordination in hematopoietic cell transplantation
Authors: Khera Nandita , Martin Patricia , Edsall Kristen , Bonagura Anthony , Burns Linda J. , Juckett Mark , King Olivia , LeMaistre C. Frederick , Majhail Navneet S. 
Published: August 2017

Abstract
Hematopoietic cell transplantation (HCT) is an expensive, resource-intensive, and medically complicated modality for treatment of many hematologic disorders. A well-defined care coordination model through the continuum can help improve health care delivery for this high-cost, high-risk medical technology. In addition to the patients and their families, key stakeholders include not only the transplantation physicians and care teams (including subspecialists), but also hematologists/oncologists in private and academic-affiliated practices. Initial diagnosis and care, education regarding treatment options including HCT, timely referral to the transplantation center, and management of relapse and late medical or psychosocial complications after HCT are areas where the referring hematologists/oncologists play a significant role. Payers and advocacy and community organizations are additional stakeholders in this complex care continuum. In this article, we describe a care coordination framework for patients treated with HCT within the context of coordination issues in care delivery and stakeholders involved. We outline the challenges in implementing such a model and describe a simplified approach at the level of the individual practice or center. This article also highlights ongoing efforts from physicians, medical directors, payer representatives, and patient advocates to help raise awareness of and develop access to adequate tools and resources for the oncology community to deliver well-coordinated care to patients treated with HCT. Lastly, we set the stage for policy changes around appropriate reimbursement to cover all aspects of care coordination and generate successful buy-in from all stakeholders.
Model checking in multiple imputation: an overview and case study
Authors: Nguyen Cattram D. , Carlin John B. , Lee Katherine J. 
Published: August 2017

Abstract
Background
Multiple imputation has become very popular as a general-purpose method for handling missing data. The validity of multiple-imputation-based analyses relies on the use of an appropriate model to impute the missing values. Despite the widespread use of multiple imputation, there are few guidelines available for checking imputation models.

Analysis
In this paper, we provide an overview of currently available methods for checking imputation models. These include graphical checks and numerical summaries, as well as simulation-based methods such as posterior predictive checking. These model checking techniques are illustrated using an analysis affected by missing data from the Longitudinal Study of Australian Children.

Conclusions
As multiple imputation becomes further established as a standard approach for handling missing data, it will become increasingly important that researchers employ appropriate model checking approaches to ensure that reliable results are obtained when using this method.
Iterative metal artefact reduction (MAR) in postsurgical chest CT: comparison of three iMAR-algorithms
Authors: Aissa Joel , Boos Johannes , Sawicki Lino Morris , Heinzler Niklas , Krzymyk Karl , Sedlmair Martin , Kröpil Patric , Antoch Gerald , Thomas Christoph 
Published: August 2017

Objectives:
The purpose of this study was to evaluate the impact of three novel iterative metal artefact (iMAR) algorithms on image quality and artefact degree in chest CT of patients with a variety of thoracic metallic implants.

Methods:
27 postsurgical patients with thoracic implants who underwent clinical chest CT between March and May 2015 in clinical routine were retrospectively included. Images were retrospectively reconstructed with standard weighted filtered back projection (WFBP) and with three iMAR algorithms (iMAR-Algo1 = Cardiac algorithm, iMAR-Algo2 = Pacemaker algorithm and iMAR-Algo3 = ThoracicCoils algorithm). The subjective and objective image quality was assessed.

Results:
Averaged over all artefacts, artefact degree was significantly lower for the iMAR-Algo1 (58.9 ± 48.5 HU), iMAR-Algo2 (52.7 ± 46.8 HU) and the iMAR-Algo3 (51.9 ± 46.1 HU) compared with WFBP (91.6 ± 81.6 HU, p &lt; 0.01 for all). All iMAR reconstructed images showed significantly lower artefacts (p &lt; 0.01) compared with the WFPB while there was no significant difference between the iMAR algorithms, respectively. iMAR-Algo2 and iMAR-Algo3 reconstructions decreased mild and moderate artefacts compared with WFBP and iMAR-Algo1 (p &lt; 0.01).

Conclusion:
All three iMAR algorithms led to a significant reduction of metal artefacts and increase in overall image quality compared with WFBP in chest CT of patients with metallic implants in subjective and objective analysis. The iMARAlgo2 and iMARAlgo3 were best for mild artefacts. IMARAlgo1 was superior for severe artefacts.

Advances in knowledge:
Iterative MAR led to significant artefact reduction and increase image-quality compared with WFBP in CT after implementation of thoracic devices. Adjusting iMAR-algorithms to patients’ metallic implants can help to improve image quality in CT.
Multimodal image registration for the identification of dominant intraprostatic lesion in high-precision radiotherapy treatments
Authors: Ciardo Delia , Jereczek-Fossa Barbara Alicja , Petralia Giuseppe , Timon Giorgia , Zerini Dario , Cambria Raffaella , Rondi Elena , Cattani Federica , Bazani Alessia , Ricotti Rosalinda , Garioni Maria , Maestri Davide , Marvaso Giulia , Romanelli Paola , Riboldi Marco , Baroni Guido , Orecchia Roberto 
Published: August 2017

Abstract

Purpose:
The integration of CT and multiparametric MRI (mpMRI) is a challenging task in high-precision radiotherapy for prostate cancer. A simple methodology for multimodal deformable image registration (DIR) of prostate cancer patients is presented.

Methods:
CT and mpMRI of 10 patients were considered. Organs at risk and prostate were contoured on both scans. The dominant intraprostatic lesion was additionally delineated on MRI. After a preliminary rigid image registration, the voxel intensity of all the segmented structures in both scans except the prostate was increased by a specific amount (a constant additional value, A), in order to enhance the contrast of the main organs influencing its position and shape. 70 couples of scans were obtained by varying A from 0 to 800 and they were subsequently non-rigidly registered. Quantities derived from image analysis and contour statistics were considered for the tuning of the best performing A.

Results:
A = 200 resulted the minimum enhancement value required to obtain statistically significant superior registration results. Mean centre of mass distance between corresponding structures decreases from 7.4 mm in rigid registration to 5.3 mm in DIR without enhancement (DIR-0) and to 2.7 mm in DIR with A = 200 (DIR-200). Mean contour distance was 2.5, 1.9 and 0.67 mm in rigid registration, DIR-0 and DIR-200, respectively. In DIR-200 mean contours overlap increases of +13 and +24% with respect to DIR-0 and rigid registration, respectively.

Conclusion:
Contour propagation according to the vector field resulting from DIR-200 allows the delineation of dominant intraprostatic lesion on CT scan and its use for high-precision radiotherapy treatment planning.

Advances in knowledge:
We investigated the application of a B-spline, mutual information-based multimodal DIR coupled with a simple, patient-unspecific but efficient contrast enhancement procedure in the pelvic body area, thus obtaining a robust and accurate methodology to transfer the functional information deriving from mpMRI onto a planning CT reference volume.
A robotic C-arm cone beam CT system for image-guided proton therapy: design and performance
Authors: Hua Chiaho , Yao Weiguang , Kidani Takao , Tomida Kazuo , Ozawa Saori , Nishimura Takenori , Fujisawa Tatsuya , Shinagawa Ryousuke , Merchant Thomas E 
Published: August 2017

Objective:
A ceiling-mounted robotic C-arm cone beam CT (CBCT) system was developed for use with a 190° proton gantry system and a 6-degree-of-freedom robotic patient positioner. We report on the mechanical design, system accuracy, image quality, image guidance accuracy, imaging dose, workflow, safety and collision-avoidance.

Methods:
The robotic CBCT system couples a rotating C-ring to the C-arm concentrically with a kV X-ray tube and a flat-panel imager mounted to the C-ring. CBCT images are acquired with flex correction and maximally 360° rotation for a 53 cm field of view. The system was designed for clinical use with three imaging locations. Anthropomorphic phantoms were imaged to evaluate the image guidance accuracy.

Results:
The position accuracy and repeatability of the robotic C-arm was high (&lt;0.5 mm), as measured with a high-accuracy laser tracker. The isocentric accuracy of the C-ring rotation was within 0.7 mm. The coincidence of CBCT imaging and radiation isocentre was better than 1 mm. The average image guidance accuracy was within 1 mm and 1° for the anthropomorphic phantoms tested. Daily volumetric imaging for proton patient positioning was specified for routine clinical practice.

Conclusion:
Our novel gantry-independent robotic CBCT system provides high-accuracy volumetric image guidance for proton therapy.

Advances in knowledge:
Ceiling-mounted robotic CBCT provides a viable option than CT on-rails for partial gantry and fixed-beam proton systems with the added advantage of acquiring images at the treatment isocentre.
Lumbar spine evaluation: accuracy on abdominal CT
Authors: Klein Mitchell A. 
Published: August 2017

Objective:
To determine if the lumbar spine can be accurately evaluated on an abdominal CT.

Methods:
The electronic medical records at our institution were searched to find all consecutive patients who had an abdominal CT within 12 months of a lumbar spine MRI obtained between 01 November 2010 and 31 October 2015. The abdominal CT studies were retrospectively reviewed in a blinded fashion for the presence of any significant lumbar spine abnormalities. The prospective lumbar spine MRI reports were used as the standard of reference.

Results:
5,031 patients had lumbar spine MRI studies at our institution during the study period of 01 November 2010 to 31 October 2015. 144 patients met the inclusion criteria of our study. No patients were excluded. 107 patients had 256 abnormal findings on the lumbar spine MRI studies. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of abdominal CT in lumbar spine evaluation on a per patient/per finding basis were 89.7/95.3%, 97.3/100%, 99.0/99.2%, 76.6/99.8% and 91.7/99.8%, respectively.

Conclusion:
Despite several limitations (e.g. spinal cord assessment, bone marrow assessment and quantum mottle) compared with evaluation of the lumbar spine using MRI, evaluation of the lumbar spine on abdominal CT studies can be accurately performed with current state of the art CT scanners. Additional prospective studies are needed for a more definitive analysis.

Advances in knowledge:
With recent advances in CT technology, accurate evaluation of the lumbar spine on abdominal CT studies is feasible, potentially providing significant additional information to patients without additional imaging.
A national UK survey of radiology trainees special interest choices: what and why?
Authors: Parvizi Nassim , Bhuva Shaheel 
Published: August 2017

Objectives:
A national survey was designed to better understand factors influencing special interest choices, future aspirations of UK radiology trainees and perceptions of breast radiology.

Methods:
A SurveyMonkey questionnaire was developed and distributed to all radiology trainees in the UK through the British Institute of Radiology, RCR Junior Radiologists Forum and by directly contacting UK training schemes as well as by social media between December 2015 and January 2016.

Results:
From 21 training schemes across the UK, 232 responses were received. Over half entered radiology after foundation training and 62% were ST1-3; one-fifth of trainees intended to leave the NHS. The most popular special interests were musculoskeletal (18%), abdominal imaging (16%) and neuroradiology (13%). Gynaecological and oncological imaging proved to be the least popular. Strong personal interest, a successful rotation during training, a mix of imaging modalities, direct impact on patient care and job prospects were the most popular factors influencing career choice. Research and potential for private income were the least influential factors.
Respondents detailed their perceptions of breast radiology, selecting an awareness of career prospects (41%) and a better trainee experience (36%) as factors that would increase their interest in pursuing it as a career.

Conclusion:
Understanding the factors that influence special interest choice is essential to addressing the alarming staffing shortfalls that will befall certain radiology special interests. Addressing trainee’s preconceptions and improving the trainee experience are key to attracting trainees to breast radiology.

Advances in knowledge:
This is the first survey of its kind in the UK literature designed to evaluate special interest career choices and the factors that influence those among radiology trainees.
Radiological predictors of complete cytoreduction in 59 patients with peritoneal mesothelioma treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at a UK referral centre
Authors: Chandramohan Anuradha , Thrower Andrew , Shah Nehal , Mohamed Faheez 
Published: August 2017

Objective:
To assess the imaging features of peritoneal mesothelioma and identify key anatomical sites that aid patient selection for complete cytoreduction.

Methods:
Pre-operative imaging of 59 (32 males, 27 females) patients who underwent cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) for histologically proven peritoneal mesothelioma [36 malignant peritoneal mesothelioma, 23 cystic mesothelioma were reviewed. Imaging findings were correlated with surgical outcome. Best imaging predictors of complete cytoreduction, n = 22 and major tumour debulking, n = 12 were assessed.

Results:
Most patients (88.9%) had diffuse peritoneal disease with mean radiological peritoneal cancer index of 18 ± 12 (range 2–39). Disease in the lesser omentum (n = 10), porta hepatis (n = 8), perigastric area (n = 5), mesentery (n = 25), small bowel (n = 17), hydronephrosis (n = 1), concurrent pleural disease (n = 2), lymph nodes (n = 1) and abdominal wall disease (n = 4) was considered unfavourable. While 78.9% of patients who underwent complete cytoreduction had no disease at unfavourable sites, 75% of those who underwent MTD did have disease at these sites. There was significant difference in the radiological peritoneal cancer index, severity of upper abdominal disease, small bowel and mesenteric involvement between patients who underwent complete cytoreduction and MTD for malignant peritoneal mesothelioma. Complete cytoreduction was not achieved in the presence of a rind of soft tissue around the small bowel (p = 0.016) and was unlikely in the presence of large volume upper abdominal disease (p = 0.06).

Conclusion:
Involvement of key anatomical sites such as small bowel serosa and large volume upper abdominal disease reduced the likelihood of achieving complete cytoreduction in patients with malignant peritoneal mesothelioma.

Advances in knowledge:
Demonstration of small bowel disease and large volume upper abdominal disease on imaging in patients with malignant peritoneal mesothelioma can be used to identify patients who may not benefit from cytoreductive surgery.
Blurring the Boundaries: The Interplay of Gender and Local Communities in the Commercialization of Social Ventures
Authors: Dimitriadis Stefan , Lee Matthew , Ramarajan Lakshmi , Battilana Julie 
Published: August 2017

This paper examines the critical role of gender in the commercialization of social ventures. We argue that cultural beliefs about what is perceived to be appropriate work for each gender influence how founders of social ventures incorporate commercial activity into their ventures. Specifically, we argue and show that although cultural beliefs that disassociate women from commercial activity may result in female social venture founders being less likely to use commercial activity than their male counterparts, these effects are moderated by cultural beliefs about gender and commercial activity within founders’ local communities. The presence of female business owners in the same community mitigates the role of founders’ gender on the use of commercial activity. We examine these issues through a novel sample of 584 social ventures in the United States. We constructively replicate and extend these findings with a supplemental analysis of a second sample, the full population of new nonprofit organizations founded during a two-year period in the United States (n = 31,160). By highlighting how gendered aspects of both the social and commercial sectors interact to shape the use of commercial activity by social venture founders, our findings contribute to research on hybrid organizations in the social sector, communities as a context for the enactment of gender, and the enactment of gender in entrepreneurship.The online appendix is available at https://doi.org/10.1287/orsc.2017.1144 .
Engagement for Students With Severe Intellectual Disability: The Need for a Common Definition in Inclusive Education
Authors: Hollingshead Aleksandra , Carnahan Christina R. , Lowrey K. Alisa , Snyder Kathleen 
Published: August 2017

Abstract
Classroom engagement is an area of frequent discussion and study in the field of education, though engagement is defined differently for various student populations. The purpose of this article is to examine how engagement is defined for students without disability, at risk, or with mild disability as compared to those with severe intellectual disability. We discuss engagement for both populations of students and the resulting implications for inclusive practice. Finally, we emphasize the importance of utilizing a universal definition within the framework of the Universal Design for Learning to enhance learning outcomes for all students, including those with severe intellectual disability.
Exploring the Impact of Community Service on Career Exploration, Self-Determination, and Social Skills for Transition-Age Youth With Autism Spectrum Disorders
Authors: Timmons Jaimie , Zalewska Agnieszka , Hall Allison Cohen , Fesko Sheila 
Published: August 2017

Abstract
Bleak transition outcomes for youth with autism spectrum disorder (ASD), coupled with the surge in incidence, has led to the need for focused and innovative transition strategies. While structured community service reveals promise, documentation of how community service experiences contribute to building employment skills for youth with intellectual and developmental disability (IDD), including those with ASD, is underresearched. The purpose of this paper is to explore the impact of a community service experience on employment skill-building for youth with ASD. Findings from 23 qualitative interviews with a range of stakeholders showed positive perceptions in the areas of career exploration, self-determination, and social skill building. Implications emphasize the likely benefits of structured community service and the potential to maximize the connection to employment, and thus community inclusion, for transition-age youth with ASD.
Constructing the singing voice: Vocal style, aesthetics and the body in Okinawan music
Authors: Gillan Matt 
Published: August 2017

Abstract
Japan’s southernmost prefecture of Okinawa has a thriving traditional music culture that has become popular throughout the country, and has also become the basis for a more modern Okinawan pop music scene. Most Okinawan musical genres strongly emphasize vocal technique – vocal timbre, inflection and ornamentation are all singled out as being cultural markers that differentiate Okinawan genres from each other and from the vocal music of the Japanese mainland. Vocal techniques have long been theorized and mediated through both written and verbal aesthetic discourses, and the voice continues to be a way that regional identities, lineage affiliations and other aspects of Okinawan society are negotiated. In this article I draw on fifteen years as a researcher and performer of Okinawan folk and classical vocal traditions, as well as recent recorded interviews with performers and music producers, to analyse how these discourses function, and how they have interacted with changes in performance practice since the early twentieth century.
Singing the nation: Contemporary Greek rebetiko performance as carnivalesque
Authors: Stamatis Yona 
Published: August 2017

Abstract
Significant ethnomusicological research examines the use of traditional song to embody, perform and promote nationalist sentiment in the contemporary globalizing world. Traditional song as a mechanism for national critique has received less scholarly attention. This is a particularly prominent phenomenon within the contemporary European Union, where the utopian ideal of an increasingly borderless and multicultural region conflicts with conventional structures and ideologies of national belonging. This article examines the popular Rebetiki Istoria club in Athens, Greece, as carnivalesque resistance to state-sanctioned Europeanization projects. Engaging the four categories of a ‘carnivalistic sense of the world’, as outlined by Mikhail Bakhtin, this study examines this rebetiko culture as structurally coherent resistance to crypto-colonialist attitudes towards Greece. Emphasizing the role of heteroglossic dialogue in shaping carnivalesque music culture, the article examines how voice and singing in the music culture of this particular club level social hierarchies, and challenge dominant ideologies of national identity. Primary consideration is given to vocal style in the framing of rebetika as carnivalesque, suggesting that a particular politics of voice within the club frames rebetika as strategic commentary on narratives of self and other. In this study, the voice is understood as phonosonic nexus – both an embodied physical presence and a metaphor for intention and authority – that shapes the interpretive frame and signals a particular metanarrative of resistance and subversion guiding the carnivalesque nature of the music culture in the club.
Songs of tradition as training in higher education?
Authors: Berkeley-Schultz Ditte , Behrens Electa 
Published: August 2017

Abstract
What can be the benefit of working with traditional song in the context of a university or conservatory? Who is qualified to teach this practice, what are the needed conditions for successful transmission, what are the ‘skills’ that a student might learn from this work and are they relevant to a contemporary performer? This is a transcript of an ongoing dialogue between two artist practitioners who have worked in this area over the last fifteen years. Ditte Berkeley is a founding member of Teatr ZAR, a company that has conducted deep research into songs of tradition as well as their application within performative contexts. Electa Behrens, also with a background working with traditional song, now teaches at the Norwegian Theatre Academy, an international experimental conservatory, where she teaches and researches voice training and its relation to emerging, often post-dramatic, performance forms. This dialogue offers insights regarding the underlying principles of performance that these methods, insightfully applied, can offer, and invites further conversation on the topic.