bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between psychological resilience, social support and oral health behaviours in patients with implant dentures
Authors: Cui Tingting , Qiu Liying , Hou Deqiang 
Published: October 2024

Abstract

Background
Dental defects and missing teeth, as common oral diseases, seriously affect the quality of life of patients. With the improvement of living standards, implant dentures have become the choice of more and more patients with missing teeth, but dentures are not natural teeth, and they still cause different degrees of negative impacts on patients in physiological, psychological and social aspects. There are fewer studies on the relationship between psychological resilience, social support and oral health behaviours in patients with implant dentures. The objective of this study is to examine the current status of psychological resilience among implant denture patients and the factors that influence it. Additionally, we aim to analyse the correlation between psychological resilience, social support, and oral health behaviours, with a view to providing a scientific basis for the development of targeted interventions for patients with implant dentures.
Methods
A survey of 238 patients with implant dentures was conducted in the Department of Stomatology of the Affiliated Hospital of Jiangnan University and Wuxi Stomatological Hospital. The survey included a self-designed general information questionnaire, disease condition questionnaire,The Connor-Davidson Resilience Scale(CD-RISC), The Social Support Rating Scale (SSRS), and The oral health behavior scale.
Results
A total of 238 patients participated in this study.The CD-RISC score of patients with implant dentures was 66.49 ± 15.59, while the SSRS score was 37.90 ± 7.73, and the oral health behaviour score was 34.73 ± 7.92, multiple linear regression analysis showed that age, economic status, social support, and oral health behavioural status were the factors influencing the psychological resilience of patients with implant dentures (all P < 0.05),and the psychological resilience score was positively correlated with the score of oral health behaviours and the score of social support (P < 0.05), and the score of oral health behaviours was positively correlated with the score of social support (P < 0.05). Oral health behaviour partially mediated the relationship between psychological resilience and social support (mediating effect 0.11, accounting for 26.2% of the total effect).
Conclusions
The postoperative psychological elasticity of patients with implant dentures is at an average level and is affected by various factors, among which social support not only has a direct effect on the psychological elasticity of patients with implant dentures, but also has an indirect effect on their psychological elasticity through oral health behaviours. Healthcare professionals should actively adopt targeted nursing interventions to improve the psychological resilience of patients, improve their postoperative oral health behaviours, and improve their quality of life.
Correlation of Precisely Fabricated Geometric Characteristics of DNA-Origami Nanostructures with Their Cellular Entry in Human Lens Epithelial Cells
Authors: Guo Yexuan , Xiong Tianze , Yan Hong , Zhang Rui Xue 
Published: October 2024

Abstract

Human lens epithelial cells (hLECs) are critical for lens transparency, and their aberrant metabolic activity and gene expression can lead to cataract. Intracellular delivery to hLECs, especially to sub-cellular organelles (e.g., mitochondrion and nucleus), is a key step in engineering cells for cell- and gene- based therapies. Despite a broad variety of nano- and microparticles can enter cells, their spatial characteristics relevant to cellular uptake and localization remains elusive. To investigate cellular internalization in hLECs, herein, four distinct, mass-controlled nanostructures were precisely fabricated through computer-aided DNA-origami design. Ensembled DNA-origami nanostructures (DONs) included the rods, ring, triangle, and octahedron with defined geometric parameters of accessible surface area, effective volume, compactness, aspect ratio, size and vertex number. Atomic force microscopy and agarose gel electrophoresis showed that four DONs self-assembled within 3.5h with up to 59% yield and exhibited structural intactness in cell culture medium for 4h. Flow cytometry analysis of four Cy5-labelled DONs in hLECs HLE-B3 found time-dependent cellular uptake over 2h, among which the octahedron and triangle had higher cellular accumulation than the rod and ring. More importantly, the vertex number among other geometric parameters was positively correlated with cellular entry. Confocal images further revealed that four DONs had preferential localization at mitochondria to nucleus at 2h in HLE-B3 cells, and the degree of their biodistribution varied among DONs as evidenced by Manders’ correlation coefficient. This study demonstrates the DONs dependent uptake and mitochondrial localization in hLECs, heralding the future design of structure-modulating intracellular delivery for ocular therapy.
Soil microbial drought history affects tree physiology of select species
Authors: Spanier Nicole M. , Phillips Richard P. 
Published: October 2024

Abstract

Soil microbes aid in the drought tolerance of plants, yet the extent to which a microbial community’s previous drought exposure can affect plant responses to contemporary drought is largely unknown. We used a greenhouse experiment to investigate whether microbes exposed to reduced moisture in the past affect the sensitivity of trees to future water-stress. We planted saplings of 3 species in field soils exposed to experimentally-induced drought or ambient moisture from adjacent forest plots, and then altered the watering regime of the saplings to induce contemporary drought. When trees were grown in ambient soils with no drought history, contemporary drought reduced C assimilation rates, stomatal conductance, and leaf water potential in all species. However, when Prunus virginiana were grown in soils with a drought history, they were buffered from the effects of contemporary drought, as physiological performance was mostly unchanged by water stress. P. virginiana grown in drought history soils also increased soluble sugars during contemporary drought to a lesser extent than those in soils with no drought history, suggesting the plants experienced less water stress. Sterilized soils confirmed the “soil drought history effect” likely resulted from drought-adapted microbes in soils exposed to drought previously. None of these effects were apparent in Liriodendron tulipifera and Quercus rubra, which reduced their physiological performance when water-stressed regardless of soil drought history. To the extent mature tree responses to environmental stress are similar, our results suggest that forest sensitivity to drought may depend, in part, on plant-microbial interactions shaped by past stress exposures.
Effects of rhomboid intercostal nerve, serratus anterior plane, and paravertebral block on the quality of recovery after breast cancer surgery: A randomized controlled clinical trial
Authors: Yu Jiali , Qi Yi , Wang Dan , Chen Qi , An Ran , Liu Hongliang 
Published: October 2024

Abstract

Nerve blocks are among the most important methods of postoperative analgesia in breast cancer surgery. We used a randomized controlled clinical trial to compare the effects of rhomboid intercostal nerve block (RIB), serratus anterior plane block (SAPB), and paravertebral block (PVB) on the postoperative quality of recovery and postoperative analgesia in modified radical mastectomy. A total of 132 breast cancer surgery patients were randomized 1:1:1 into three groups. 0.375% ropivacaine 20 ml for ultrasound-guided RIB (RIB group, n = 44), SAPB (SAPB group, n = 44), and PVB (PVB group, n = 44). The primary outcome was the QoR-40 score at 24 hours after surgery. The postoperative 24-hour QoR-40 scores of the RIB (median: 186; interquartile range: 177, 190.5) and PVB (median: 186.5; interquartile range: 176.25, 190.5) groups were higher than those of the SAPB group (median: 168; interquartile range: 163.25, 172) (P < 0.001). In addition, the intraoperative sufentanil consumption (P < 0.001), number of intraoperative sufentanil users (P < 0.001), and postintubation NRS scores (P = 0.01) of the RIB and PVB groups were significantly lower than those of the SAPB group, but there was no statistically significant difference between the RIB and PVB groups. Compared with SAPB, RIB and PVB improve the quality of postoperative recovery, reduce intraoperative opioid use, and improve early postoperative analgesia. RIB may be one of the best alternatives to PVB as a facial plane block.
Association between non-high-density lipoprotein cholesterol and coronary artery disease in patients with acute coronary syndrome: a single-centre retrospective cross-sectional analysis
Authors: Yang Xueyuan , Li Kui , Xu Guanxue , Wen Jiaojiao , Xiao Hong , Chen Lei , Yang Changlong , Chen Yuxuan , Liu Yanmiao , Zhao Yongchao , Shi Bei , Ma Yi 
Published: October 2024

Abstract

Background
A significant relationship exists between atherosclerotic cardiovascular disease (ASCVD) and non-high-density lipoprotein cholesterol (non-HDL-C). However, the relationship between non-HDL cholesterol levels and coronary artery disease in patients with acute coronary syndrome (ACS) remains under-researched and poorly understood. Therefore, this study aimed to explore the association between non-HDL-C and coronary artery disease in individuals with ACS.
Methods
This single-centre retrospective cross-sectional study included 1695 patients with ACS who underwent percutaneous coronary intervention at Zunyi Medical University's Affiliated Hospital from May 2019 to May 2023. The patients were categorised into three groups based on non-HDL cholesterol tertiles. The severity of coronary artery disease was assessed using the Gensini score, and patients were categorised into high and low Gensini score groups. Logistic regression models, including multifactorial adjustments, were used to analyse the association between non-HDL-C levels and high Gensini scores.
Results
After adjusting for potential risk factors, multifactorial logistic regression (odds ratio [OR] = 1.20; 95% confidence interval [CI] = 1.10–1.31; p < 0.001) revealed that non-HDL-C was an independent risk factor for high Gensini scores. After subgrouping based on age, sex, and glucose metabolic status, non-HDL-C remained an independent risk factor for high Gensini scores in these subgroups. Restricted cubic spline analysis revealed that a higher non-HDL-C level was associated with a greater the risk of having a high Gensini score. Receiver operating characteristic curve analysis revealed that non-HDL-C was incrementally predictive of high Gensini scores in patients with ACS.
Conclusions
Non-HDL-C is dose-dependently associated with the severity of coronary artery disease in patients with ACS. These findings suggest the potential of non-HDL-C in predicting its severity, supporting its use as a cost-effective and accessible marker for assessing coronary artery disease risk.
Hydrogeomorphological dynamics and erosion of the soft coasts in tropical Africa, the case study of the Wouri estuary, Cameroon
Authors: Fendoung Mbevo , Hubert-Ferrari Aurélia 
Published: October 2024

Abstract

Coastal erosion affects all countries along Africa's Atlantic coast, with flooding being the second most significant threat after erosion. In Cameroon, this phenomenon is particularly alarming, especially along the Kribian coast and in the Wouri estuary. Cape Cameroon in the Wouri estuary is experiencing severe erosion. The question arises whether the current erosion in the Wouri estuary is due to internal factors or part of a broader dynamic affecting all Atlantic African coasts. This inquiry aims to understand the causes of coastal erosion in the Wouri estuary. To address this, we used a large-scale map based on Landsat images (30m spatial resolution) covering the entire Wouri estuary and a smaller-scale map based on Pleiades images (0.5m spatial resolution) focusing on Cape Cameroon. The Digital Shoreline Analysis System (DSAS) in ArcGis 10.7.1 facilitated this analysis. Aerial photographs from 1916 to 2016 helped assess changes in Douala and their impact on mangroves over time. Diachronic land cover analysis employed Landsat images and the maximum likelihood algorithm. The Landsat results indicate that coastal erosion affects over 75% of the Wouri estuary's coastline, with average recession rates ranging from ± 3m to ± 11m between 1975 and 2020. Hotspots of regression include Cape Cameroon, the coastal spit around Manoka Island, and the area near the APD. High-resolution images from Pleiades and Google Earth confirm the severity of coastal erosion. The northern tip of Cape Cameroon is retreating at an estimated rate of + 15m/year, with the most significant recession measured at the tip of Cape Cameroon, estimated at 53 meters. A small accretion of + 5m is visible at Toubé, spanning no more than 100 meters.
Representational drawing ability is associated with the syntactic language comprehension phenotype in autistic individuals
Authors: Vyshedskiy Andrey , Venkatesh Rohan , Khokhlovich Edward 
Published: October 2024

Abstract

The relationship between symbolic thinking and language abilities is a topic of intense debate. We have recently identified three distinct language comprehension phenotypes: command, modifier and syntactic (Vyshedskiy et al., 2024). Individuals in the command phenotype were limited to comprehension of simple commands, while those in the modifier phenotype showed additional comprehension of color, size, and number modifiers. Finally, individuals in the most-advanced syntactic phenotype added comprehension of spatial prepositions, verb tenses, flexible syntax, possessive pronouns, complex explanations, and fairytales. In this report we analyzed how these three language phenotypes differed in their symbolic thinking as evidenced by their drawing abilities. In a cohort of 39,654 autistic individuals 4- to 21-years-of-age, parents reported that ‘drawing, coloring and art’ was manifested by 36.0% of participants. Among these individuals, representational drawing was manifested by 54.1% of individuals with syntactic-phenotype, 27.7% of those with modifier-phenotype, and 10.1% of those with command-phenotype (all pairwise differences between the phenotypes were statistically significant, p < 0.0001). The ability to draw a novel image per parent’s description (e.g. a three-headed horse) was reported by 34.6% of individuals with syntactic-phenotype, 7.9% of those with modifier- phenotype, and 1.9% of individuals with command-phenotype (all pairwise differences between the phenotypes were statistically significant, p < 0.0001). These results demonstrate strong association between representational drawing ability and the syntactic-language-comprehension-phenotype, suggesting a potential benefit of drawing interventions in language therapy.
Gut commensal Alistipes as a potential pathogenic factor in colorectal cancer
Authors: Fu Jingjing , Li Guangyao , Li Xiaoping , Song Shasha , Cheng Lijuan , Rui Beibei , Jiang Lei 
Published: October 2024

Abstract

Although previous research has shown that inflammation is associated with development of colorectal cancer (CRC), questions remain about whether inflammatory factor-secreting bacteria play a crucial role in CRC development. The potential role of gut microbiota in secreting inflammatory factors involved in the development of CRC among Chinese patients was explored in this study. 16S rRNA sequencing was utilized to evaluate the distinct microbial characteristics between patients with CRC and colorectal adenoma. Serum levels of inflammatory factors and the expression level of LRG1 tissue protein were studied. The correlation between gut microbiota and inflammatory signaling was analyzed to explore potential molecular mechanisms of CRC. Compared with the adenoma group, CRC patients exhibit distinct pathologies. Moreover, elevated levels of CEA, erythrocytes and haemoglobin in the blood of CRC patients were found. In addition, CRC patients have significantly higher levels of TNF-α, IL-6, IL-10, LRG1 and TGF-β1 when compared with adenoma patients. Spearman correlation analysis revealed that LRG1 was positively related to IL-6 and TNF-α, respectively. The correlation analysis result of TGF-β1 was consistent with the above. Furthermore, we found that the relative abundance of gut commensal Alistipes was significantly elevated in CRC patients. Moreover, a positive correlation between Alistipes and inflammatory signaling was also found. The results suggest that gut commensal Alistipes is a key bacterium with pro-inflammatory properties in the development of CRC. TNF-α and IL-6 associated with Alistipes might activate LRG1-TGF-β1 signaling which contributed to the pathogenesis of CRC.
Optimal Time for Collateral Channel Wiring in Retrograde Chronic Total Occlusion Percutaneous Coronary Intervention
Authors: Lee Kyusup , Kim Tae Oh , Kwon Woojin , Yoon Yong-Hoon , Kwon Osung , Lee Jong-Young , Lee Pil Hyung , Kang Soo-Jin , Kim Young-Hak , Lee Cheol Whan , Lee Seung-Whan 
Published: October 2024

Abstract

Collateral channel wiring (CCW) is important in a retrograde chronic total occlusion (CTO) procedure. However, the guidance is insufficient. To investigate the optimal CCW time, patients who had received retrograde CTO procedures were enrolled. The optimal CCW time was derived by Receiver Operating Characteristic curves regarding success rates or complications. The clinical outcomes in terms of success and complication rates were addressed by cutoff value of optimal CCW time. With cutoff values of 25 minutes, 191 (54.9%) had shorter CCW times and 157 (45.1%) had longer CCW times. The success rates were significantly higher in the group with shorter CCW times than in the group with longer CCW times (p < 0.05). Procedure-related myocardial infarction (MI) and collateral channel (CC) related complications were more frequently observed in longer CCW times group than shorter group. The CCW time less than 25 minutes was more likely to result in a technical success (adjusted odds ratio [aOR]: 3.69) and the odds of CC perforation decreased by approximately 80% (aOR: 0.20). A CCW time of less than 25 minutes may facilitate the success results and minimize the risk of complications in retrograde CTO procedures.
Development for a novel phantom for evaluating image quality in small-animal single photon emission computed tomography and positron emission tomography.
Authors: Shibutani Takayuki , Onoguchi Masahisa , Kannno Takayuki 
Published: October 2024

Abstract

Objectives
The National Electrical Manufacturers Association (NEMA) has released guidelines delineating the performance of positron emission tomography (PET) devices designed for small animals. However, the NEMA NU 4 image quality phantom could not measure the known contrasts of the hot rod images and the recovery coefficient (RC) of cold rod images due to the structure of the phantom. Thus, we have devised novel hot rod and cold rod phantoms capable of evaluating uniformity and RCs for both hot rod and cold rod images. This study aimed to assess uniformity, image contrasts, and RCs in hot rod and cold rod images of single photon emission computed tomography (SPECT) and PET using the newly developed phantom.
Methods
The new physical phantom consisted of rod and pool sections. To assess image uniformity, the pool section, designed in a cylindrical shape, was utilized. Conversely, the rod section was created in hot rod and cold rod shapes and integrated into a cylindrical phantom with the same design as the pool section. Hot rod and cold rod phantoms were designed with six different 1–6 mm diameter rods. The rod and pool sections of the hot rod phantom were separately filled with 99mTc and 18F solutions. In the rod section, the cylindrical part was defined as the background (BG), with a radioactive concentration ratio of 4:1 for the hot rod and BG. The cylindrical part containing the cold rod was separately filled with 99mTc and 18F solutions. The 99mTc and 18F phantoms were acquired separately over 30 min. A transverse image with a cubic voxels of 0.8 mm length was reconstructed using a pixel-based ordered subset expectation maximization algorithm.
Results
The contrast of the hot rod for 99mTc and 18F showed lower values with a decreasing rod diameter. Furthermore, the 99mTc image demonstrated a higher contrast than the 18F image and approached the true contrast. The cold rod contrasts with 99mTc and 18F followed a similar trend as the hot rod contrast. The RCs for the hot rods with 4–6 mm diameters were similar, whereas hot rods with diameters ≤ 3 mm revealed lower values as the rod diameter decreased. The inverse RC was lower with a decreasing cold rod diameter. Moreover, the cold rod image with 18F demonstrated a lower inverse RC than with the 99mTc. The percent coefficient of variation (%CV) for the 99mTc and 18F images was 4% and 7%, respectively, with the 99mTc image displaying a lower %CV compared to the 18F image.
Conclusion
We have developed a new phantom that allows physical phenomenon evaluation in small animal SPECT and PET images, and can evaluate the image contrast, RC, and uniformity of both hot rod and cold rod images.
Usefulness of monitoring Mycophenolic Acid Exposure in Systemic Sclerosis- Related Interstitial Lung Disease: A Retrospective Cohort Study
Authors: Milesi Jules , Sampol Emmanuelle , Benyamine Audrey , Diai Shani , Coiffard Benjamin , Nieves Ana , Granel Brigitte , Reynaud-Gaubert Martine , Bermudez Julien 
Published: October 2024

Abstract

Background: Systemic sclerosis-related interstitial lung disease (SSc-ILD) represents a significant cause of morbidity and mortality in Systemic Sclerosis (SSc). Mycophenolate mofetil (MMF) is currently the first line treatment for SSc-ILD. There is no recommendation on the dosage of mycophenolic acid (MPA) blood concentrations, so we aimed to study the correlation between MPA exposure and respiratory outcomes in this population.
Methods: We conducted a retrospective cohort study of SSc-ILD patients treated with MMF in our center. According to our policy, a complete patient evaluation was performed approximately one year after MMF initiation, during which the mycophenolic acid (MPA) residual rate (RR) was measured. We analyzed the association between RR and changes in forced vital capacity (FVC) and diffusion capacity for carbon monoxide (DLCO) over time.
Results: Forty-three SSc-ILD patients were included. Patients with higher RR levels (1.5 mg/L) had a significantly better FVC evolution with a higher proportion of stabilization and lower proportion of FVC decrease (p= 0.024). RR above 1.5 mg/L was a predictive factor of reduced FVC decline compared with lower RR levels adjusting for MMF dose and duration of MMF exposure (p= 0.008). There was no difference regarding DLCO outcome.
Conclusion: Our study suggests that optimal MPA exposure, as indicated by RR levels, may better protect against FVC decline in SSc-ILD patients treated with MMF. Routine monitoring of MPA exposure could be beneficial in optimizing treatment outcomes. Prospective, multicenter studies are needed to further explore the relationship between MPA exposure and clinical outcomes in SSc-ILD.