bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and 3‐year persistence of human papillomavirus serotypes in asymptomatic patients in Northern Mexico
Authors: Fajardo‐Ramírez Oscar R. , Barboza‐Cerda María C. , Ortiz‐López Rocío , Rojas‐Martínez Augusto , Garza‐Rodríguez María L. , Sepúlveda‐Flores Abel , González‐Guerrero Juan F. , Bernal‐Silva Sofía , Cerda‐Flores Ricardo M. , Calleja‐Macías Itzel E. , Rodríguez‐Flores Socorro , Sandoval‐Guzmán Esthela , Plascencia‐Solis Teresa , Pérez‐Reyes Patricia , Villarreal Jesús Z. , Barrera‐Saldaña Hugo A. 
Published: July 2017

AbstractObjectiveTo investigate clinical outcomes and 3‐year persistence of human papillomavirus (HPV) infections among women in Mexico.MethodsA prospective study enrolled sexually active women attending primary healthcare clinics in metropolitan Monterrey, Mexico, between June 3 and August 30, 2002. Baseline data were collected and participants underwent HPV screening. Patients with HPV infections were asked to attend a repeat screening appointment after 3 years, when the same screening data were gathered. Descriptive analyses were performed and the prevalence of cervical lesions and viral infections were examined.ResultsIn total, 1188 patients who underwent initial HPV screening were included. Cervical lesions were detected in 5 (0.4%) patients and 239 (20.1%) patients had HPV infections; 129 (54.0%) of these patients attended 3‐year follow‐up. Among the 357 HPV serotypes identified, the most prevalent serotypes were HPV‐59, HPV‐52, HPV‐16, and HPV‐56, detected 62 (17.4%), 38 (10.6%), 27 (7.6%), and 18 (5.0%) times, respectively. Of the 129 patients attending 3‐year follow‐up, 104 (80.6%) were clear from HPV infections, 13 (10.1%) patients had persistent HPV infections, and 12 (9.3%) had HPV infections with different HPV types.ConclusionsThe HPV prevalence was 20.1% in the present study; the most prevalent infections were HPV‐59, HPV‐52, HPV‐16, and HPV‐56. At 3‐year follow‐up, 25 (19.4%) patients had HPV infections.
A systematic review and meta‐analysis of randomized controlled trials comparing hysteroscopic morcellation with resectoscopy for patients with endometrial lesions
Authors: Li Chunbo , Dai Zhiyuan , Gong Yuping , Xie Bingying , Wang Bei 
Published: July 2017

AbstractBackgroundResults on the efficacy of hysteroscopic morcellation for patients with endometrial lesions remain conflicting.ObjectivesTo compare hysteroscopic morcellation with conventional resectoscopy for removal of endometrial lesions.Search strategyElectronic databases were searched for reports published up to February 1, 2016, using terms such as “morcellator,” “morcellators,” “morcellate,” “morcellation,” “morcellated,” “hysteroscopy,” “hysteroscopy,” “uteroscope,” and “transcervical.”Selection criteriaRandomized controlled trials were included if they assessed success rate, procedure speed, complications, tolerability, and/or learning curve.Data collection and analysisData were extracted by two independent reviewers and a meta‐analysis was performed.Main resultsFour trials including 392 patients were analyzed. Successful removal of all endometrial lesions was more frequent with hysteroscopic morcellation than conventional resectoscopy (odds ratio 4.49, 95% confidence interval [CI] 1.94–10.41; P<0.001). Total operative time was also shorter with hysteroscopic morcellation (mean difference −4.94 minutes, 95% CI −7.20 to −2.68; P<0.001). No significant differences in complications were found. Meta‐analyses were not possible for tolerability and learning curve. In one study, hysteroscopic morcellation was acceptable to more patients (P=0.009).ConclusionsHysteroscopic morcellation is associated with a higher operative success rate and a shorter operative time among patients with endometrial lesions than is resectoscopy. More high‐quality trials are required to validate these results.
Reaching vulnerable women through maternity waiting homes in Malawi
Authors: Singh Kavita , Speizer Ilene , Kim Eunsoo Timothy , Lemani Clara , Phoya Ann 
Published: July 2017

AbstractObjectiveTo determine whether two maternity waiting homes (MWHs) supported by the Safe Motherhood Initiative are reaching vulnerable women during the early phase of their implementation.MethodsA cross‐sectional interview‐based study was conducted among women who attended two centers in Malawi with attached MWHs (Area 25 Health Centre, Lilongwe; and Kasungu District Hospital, Kasungu). Between April and June 2015, exit interviews were conducted among MWH users and non‐users.ResultsCompared with non‐users, MWH users at Area 25 were significantly more likely to report a prior spontaneous abortion (10/46 [21.7%] vs 5/95 [5.3%]; P=0.006) and to be in the lowest wealth quintile (4/87 [4.6%] vs 0/150; P=0.029). Although not significant, a greater percentage of MWH users at Kasungu District Hospital than non‐users had a prior stillbirth (6/84 [7.1%] vs 0/77) or spontaneous abortion (3/84 [3.6%] vs 2/77 [2.6%]), and were in the lowest wealth quintile (15/175 [8.6%] vs 5/141 [3.5%]). MWH users at Kasungu lived further from the hospital than did non‐MWH users, although the difference was not significant (mean 6.81±9.1 km vs 4.05±7.42 km; P=0.067).ConclusionMWHs offer a promising strategy to reduce maternal mortality in Malawi and other low‐income countries.
Preliminary study of the effects of furosemide on blood pressure during late‐onset pre‐eclampsia in patients with high cardiac output
Authors: Tamás Péter , Hantosi Eszter , Farkas Bálint , Ifi Zsolt , Betlehem József , Bódis József 
Published: July 2017

AbstractObjectiveTo examine the effect of furosemide on hypertension and edema in patients with pre‐eclampsia experiencing high cardiac output.MethodsThe present cohort study enrolled patients with pre‐eclampsia who were admitted to the pregnancy pathology unit of the Department of Obstetrics and Gynecology, University of Pécs, Hungary, between January 1 and December 31, 2015. Eligible patients had singleton pregnancies with no fetal anomalies, high blood volume, visible edema, and a hematocrit concentration below 37 L/L. Blood pressure was measured and impedance cardiography was used to determine cardiac output for all patients before they received a 40‐mg dose of furosemide; after 60 minutes blood pressure and cardiac output were measured again.ResultsThe study enrolled 14 patients. Lower cardiac output (P=0.002), systolic blood pressure (P=0.002), and diastolic blood pressure (P=0.002) were recorded after furosemide administration, with patient heart rates remaining stable.ConclusionThe heart‐rate stability suggests that the change of cardiac output was due to a decrease in blood volume. These data suggest that diuretics could be useful in the management of late‐onset pre‐eclampsia, indicating that an increase in water retention could play a role in the development of late‐onset pre‐eclampsia.
Birth preparedness and complication readiness among prenatal attendees in a teaching hospital in South West Nigeria
Authors: Aduloju Olusola P. , Akintayo Akinyemi A. , Aduloju Tolulope , Akin‐Akintayo Oladunni O. 
Published: July 2017

AbstractObjectiveTo assess birth preparedness and complication readiness (BPCR) as well as knowledge of danger signs during pregnancy, labor/delivery, and the postpartum period.MethodsA cross‐sectional study was undertaken of pregnant women attending the prenatal clinic at a tertiary hospital in Nigeria between October and December 2016. A pretested and structured questionnaire was used to collect data on BPCR, and logistic regression was performed to determine factors affecting BPCR.ResultsOf 325 participants, 274 (84.3%) had knowledge of BPCR components, and 265 (81.5%) were well prepared for birth and its complications. However, only 89 (27.4%) knew key danger signs during labor/delivery and 81 (24.9%) knew those in the first 2 days after delivery. Older age, higher parity, tertiary education of women, paid employment of women and their spouses, higher social class, frequent prenatal visits, and knowledge of danger signs were significantly associated with BPCR (P<0.05). Higher parity, maternal government employment, and knowledge of danger signs during pregnancy remained determinants of BPCR on logistic regression (P<0.05).ConclusionAlthough there was a high level of knowledge and practice of BPCR, knowledge of key danger signs was low. Therefore, prenatal education needs to be improved with an emphasis on teaching pregnant women to recognize key danger signs.
Targeting nano drug delivery to cancer cells using tunable, multi‐layer, silver‐decorated gold nanorods
Authors: Nima Zeid A. , Alwbari Ahmed M. , Dantuluri Vijayalakshmi , Hamzah Rabab N. , Sra Natasha , Motwani Pooja , Arnaoutakis Konstantinos , Levy Rebecca A. , Bohliqa Amani F. , Nedosekin Dmitry , Zharov Vladimir P. , Makhoul Issam , Biris Alexandru S. 
Published: July 2017

AbstractMultifunctional nanoparticles have high potential as targeting delivery vehicles for cancer chemotherapy. In this study, silver‐decorated gold nanorods (AuNR\Ag) have been successfully used to deliver specific, targeted chemotherapy against breast cancer (MCF7) and prostate carcinoma (PC3) cell lines. Doxorubicin, a commonly used chemotherapy, and anti‐Epithelial cell adhesion molecule (anti‐EpCAM) antibodies were covalently bonded to thiolated polyethylene glycol‐coated AuNR\Ag, and the resultant system was used to deliver the drugs to cancer cells in vitro. Furthermore, these nanoparticles have a unique spectral signature by surface enhanced Raman spectroscopy (SERS), which enables reliable detection and monitoring of the distribution of these chemotherapy constructs inside cells. The development of interest in a plasmonic nano drugs system with unique spectroscopic signatures could result in a clinical approach to the precise targeting and visualization of cells and solid tumors while delivering molecules for the enhanced treatment of cancerous tumors.
Evaluating Atypical Features of Femur Fractures: How Change in Radiological Criteria Influenced Incidence and Demography of Atypical Femur Fractures in a Community Setting
Authors: LeBlanc Erin S , Rosales A Gabriela , Black Dennis M , Genant Harry K , Dell Richard M , Friess Darin M , Boardman David L , Bauer Douglas C , de Papp Anne , Santora Arthur C , Orwoll Eric S 
Published: July 2017

ABSTRACT

Identification of atypical femoral fractures (AFFs) can be challenging. To assist in the radiological assessment, an American Society for Bone and Mineral Research (ASBMR) Task Force developed a case definition for AFFs in 2010, revising it in 2013. How the revised definition performs in a community setting compared with the 2010 definition is unknown. We applied the 2013 criteria to 372 femoral fractures that occurred between January 1, 1996, and June 30, 2009, employing two independent expert physician reviewers. We used radiographs that had been categorized in a previous study on the incidence of atypical fractures using 2010 ASMBR criteria (BEAK1). In this follow-up study (BEAK2), the same reviewers reviewed all previously identified femoral shaft fractures (FSFs) (n = 197) and distal femur fractures (n = 131) plus a 15% random sample of intertrochanteric fractures (n = 49). After initial review, agreement between the two reviewers ranged from 63% to 100% for specific features, and 84% of radiographs received the same overall classification. Fewer fractures met the 2013 compared with 2010 ASMBR case definition of AFFs (37 per 2013 criteria versus 74 per 2010 criteria). Forty-three radiographs (58%) categorized as AFFs according to 2010 criteria were no longer AFFs when 2013 criteria were applied, and an additional 12 non-atypical FSFs according to 2010 criteria were reclassified as AFFs according to 2013 criteria. The major cause of AFF reclassification was the change in the definition of transverse configuration. The modification of the comminution, non-traumatic, and periosteal/endosteal thickness criteria resulted in the reclassification of non-atypical FSFs to AFFs. Incidence rate of AFFs according to 2013 ASBMR criteria was lower overall during the 13 years of observation than when the 2010 ASBMR criteria were applied, although we saw a slight increase starting in 2000. As in BEAK1, we found that those with AFFs were younger, more often female, and had a higher exposure rate to bisphosphonates than those with non-atypical FSFs. As we continue to unravel the demographics of those who suffer from AFFs, our study adds information about how the change in criteria influences epidemiological work. © 2017 American Society for Bone and Mineral Research.
Synchrotron tomographic images from human lung adenocarcinoma: Three‐dimensional reconstruction and histologic correlations
Authors: Yi Eunjue , Han Sung‐Mi , Chang Ji‐Eun , Kim Hong‐Tae , Kim Jong‐Ki , Seo Seung‐Jun , Chung Jin‐Haeng , Jheon Sanghoon 
Published: July 2017

AbstractHigh‐resolution tomographic images using synchrotron X‐rays are expected to provide detailed reflection of microstructures, thereby allowing for the examination of histologic structures without destruction of the specimen. This study aims to evaluate the synchrotron tomographic images of mixed ground‐glass opacity excised on 5‐mm sections in comparison to pathologic examination. The Institutional Review Board of our institute approved this retrospective study, and written informed consent was obtained from each patient whose lung tissue would be used. Obtained lung cancer specimens were brought to the multiple Wiggler 6C beam line at the Pohang Light Source (PLS‐II) in Korea, and phase contrast X‐ray images were obtained in November 2016. The X‐ray emanated from a bending magnet of the electron storage ring with electron energy of 3 GeV, and a typical beam current was 320 mA. Reconstructed tomographic images were compared with images from histologic slides obtained from the same samples. Pulmonary microstructures including terminal bronchioles, alveolar sacs, and vasculature were identified with phase contrast X‐ray images. Images from normal lung tissue and mixed ground‐glass opacity were clearly distinguishable. Hyperplasia of the interalveolar septum and dysplasia of microstructure were clearly identified. The imaging findings correlated well with hematoxylin‐eosin stained specimens. Tomographic images using synchrotron radiation have the potential for clinical applications. With refinement, this technique may become a diagnostic tool for detection of lung cancer.
Differences in gadolinium retention after repeated injections of macrocyclic MR contrast agents to rats
Authors: Bussi Simona , Coppo Alessandra , Botteron Catherine , Fraimbault Valérie , Fanizzi Antonello , De Laurentiis Elisa , Colombo Serra Sonia , Kirchin Miles A. , Tedoldi Fabio , Maisano Federico 
Published: July 2017

PurposeTo compare the levels of gadolinium in the blood, cerebrum, cerebellum, liver, femur, kidneys, and skin after multiple exposure of rats to the macrocyclic gadolinium‐based contrast agents (GBCAs) gadoterate, gadobutrol, and gadoteridol.Materials and MethodsFifty male Wistar Han rats were randomized to three exposure groups (n = 15 per group) and one control group (n = 5). Animals in the exposure groups received a total of 20 GBCA administrations (four administrations per week for 5 consecutive weeks) at a dose of 0.6 mmol/kg bodyweight. After a 28‐day recovery period animals were sacrificed and the blood and tissues harvested for determination of gadolinium (Gd) levels. Gd determination was performed by inductively coupled plasma mass spectrometry (ICP‐MS).ResultsAfter 28 days' recovery no Gd was found in the blood, liver, or skin of any animal in any group. Significantly lower levels of Gd were noted with gadoteridol compared to gadoterate and gadobutrol in the cerebellum (0.150 ± 0.022 vs. 0.292 ± 0.057 and 0.287 ± 0.056 nmol/g, respectively; P < 0.001), cerebrum (0.116 ± 0.036 vs. 0.250 ± 0.032 and 0.263 ± 0.045 nmol/g, respectively; P < 0.001), and kidneys (25 ± 13 vs. 139 ± 88 [P < 0.01] and 204 ± 109 [P < 0.001], respectively). Higher levels of Gd were noted in the femur (7.48 ± 1.37 vs. 5.69 ± 1.75 and 8.60 ± 2.04 nmol/g, respectively) with significantly less Gd determined for gadoterate than for gadobutrol (P < 0.001) and gadoteridol (P < 0.05).ConclusionDifferences exist between macrocyclic agents in terms of their propensity to accumulate in tissues. The observed differences in Gd concentration point to differences in GBCA washout rates in this setting and in this experimental model, with gadoteridol being the GBCA that is most efficiently removed from both cerebral and renal tissues.Level of Evidence: 2Technical Efficacy: Stage 5J. Magn. Reson. Imaging 2018;47:746–752.
Ionization and collision induced dissociation of steroid bisglucuronides
Authors: Esquivel Argitxu , Matabosch Xavier , Kotronoulas Aristotelis , Balcells Georgina , Joglar Jesús , Ventura Rosa 
Published: July 2017

AbstractStudies on steroid metabolism are of utmost importance to improve the detection capabilities of anabolic androgenic steroids (AASs) misuse in sports drug testing. In humans, glucuronoconjugates are the most abundant phase II metabolites of AAS. Bisglucuronidation is a reaction where two separated functional groups on the same molecule are conjugated with glucuronic acid. These metabolites have not been studied in depth for steroids and could be interesting markers for doping control. The aim of the present work was to study the ionization and collision‐induced dissociation of steroid bisglucuronides to be able to develop mass spectrometric analytical strategies for their detection in urine samples after AAS administration. Because steroid bisglucuronides are not commercially available, 19 of them were qualitatively synthesized to study their mass spectrometric behavior. Bisglucuronides ionized as [M+NH4]+ in positive mode, and as [M–H]− and [M–2H]2− in negative mode. The most specific product ions of steroid bisglucuronides in positive mode resulted from the neutral losses of 387 and 405 Da (corresponding to [M+NH4–NH3–2gluc–H2O]+ and [M+NH4–NH3–2gluc–2H2O]+, respectively, being “gluc” a dehydrated glucuronide moiety), and in negative mode, the fragmentation of [M–2H]2− showed ion losses of m/z 175 and 75 (gluc− and HOCH2CO2−, respectively). On the basis of the common behavior, a selected reaction monitoring method was developed to detect bisglucuronide metabolites in urine samples. As a proof of concept, urines obtained after administration of norandrostenediol were studied, and a bisglucuronide metabolite was detected in those urines. The results demonstrate the usefulness of the analytical strategy to detect bisglucuronide metabolites in urine samples, and the formation of these metabolites after administration of AAS.
Ultrasound elastography for carpal tunnel pressure measurement: A cadaveric validation study
Authors: Kubo Kazutoshi , Zhou Boran , Cheng Yu‐Shiuan , Yang Tai‐Hua , Qiang Bo , An Kai‐Nan , Moran Steven L. , Amadio Peter C. , Zhang Xiaoming , Zhao Chunfeng 
Published: July 2017

ABSTRACTCarpal tunnel pressure is a key factor in the etiology of carpal tunnel syndrome. Numerous approaches have been conducted to measure carpal tunnel pressure. However, most techniques are invasive and take time and effort. We have developed an innovative approach to noninvasively assess the tunnel pressure by using the ultrasound surface wave elastography (USWE) technique. In a previous study it was shown that the shear wave speed in a tendon increased linearly with increasing tunnel pressure enclosed the tendon in a simple tendon model. This study aimed to examine the relationship between the carpal tunnel pressure and the shear wave speeds inside and outside the carpal tunnel in a human cadaveric model. The result showed that the shear wave speed inside the carpal tunnel increased linearly with created carpal tunnel pressure, while the shear wave speed outside the carpal tunnel remained constant. These findings suggest that noninvasive measurement of carpal tunnel pressure is possible by measuring the shear wave speed in the tendon. After fully establishing this technology and being applicable in clinic, it would be useful in the diagnosis of carpal tunnel syndrome. For that reason, further validation with this technique in both healthy controls and patients with carpal tunnel syndrome is required. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:477–483, 2018.
Growth and root architecture responses of zoysiagrass to changes in fertilizer nitrate : urea ratio
Authors: Pompeiano Antonio , Patton Aaron J. 
Published: July 2017

AbstractAlthough zoysiagrass (Zoysiaspp.) responds to nitrogen (N) application in the field, especially during the establishment phase, no guidelines are available for the preferred form of N for these species. A greenhouse experiment was performed to see how zoysiagrass responds to nitrate and urea as N sources.Z. japonicacv. El Toro (fast‐growing) and cv. Meyer (slow‐growing) andZ. matrellacv. Zorro (fast‐growing) and cv. Diamond (slow‐growing) were chosen for this study. Plants were clonally propagated as phytomers, established in 21 cm deep cone‐tainers filled with a sand‐based growth medium. The treatment consisted of a modified, half‐strength Hoagland's solution with five different nitrate : urea ratios (100 : 0, 75 : 25, 50 : 50, 25 : 75, 0 : 100). Plant responses were assessed in terms of biomass production (leaf, culm, roots, and total plant dry weight) and rooting characteristics (length, area, diameter, volume, tips, forks, crossings, and root volume ratio) 10 weeks after the initiation of the experiment. The differing sources of N resulted in changes in plant growth and development. The cultivars had different above and below‐ground biomass and root architecture traits. El Toro had the highest total biomass production (2.083 g plant−1DW), while Meyer and Zorro together averaged 0.734 g plant−1DW (65% less than El Toro). Diamond was the least productive in terms of leaf, culm, and root biomass (0.278 g plant−1DW; 87% less than El Toro). Furthermore, above‐ and below‐ground DW production was greatest following treatment with 25 : 75 nitrate:urea, whereas 100% nitrate produced plants with the lowest DW. Zoysiagrass rooting traits were only minimally influenced by N source; as the concentration of urea increased, slight increases in root surface area and volume were observed, accompanied by a decline in the root volume ratio.
Influence of high latitude light conditions on sensory quality and contents of health and sensory‐related compounds in swede roots (Brassica napus L. ssp. rapifera Metzg.)
Authors: Mølmann Jørgen AB , Hagen Sidsel Fiskaa , Bengtsson Gunnar B , Johansen Tor J 
Published: July 2017

AbstractBACKGROUNDVegetable growers in Arctic areas must increasingly rely on market strategies based on regional origin and product quality. Swede roots (rutabaga) were grown in a phytotron to investigate the effect of high latitude light conditions on sensory quality and some health and sensory‐related compounds. Experimental treatments included modifications of 24 h natural day length (69° 39' N) by moving plants at daily intervals to dark chambers with either no light, fluorescent growth light and/or low intensity photoperiod extension.RESULTSShortening the photosynthetic light period to 12 h produced smaller roots than 15.7 h and 18 h, with highest scores for bitter and sulfur taste, and lowest scores for sweetness, acidic taste and fibrousness. The photoperiod in combination with the photosynthetic light period also had an influence on glucosinolate (GLS) contents, with lowest concentrations in 24 h natural light and highest in 12 h natural light. Concentrations of vitamin C, glucose, fructose and sucrose were not significantly influenced by any of the treatments.CONCLUSIONHigh latitude light conditions, with long photosynthetic light periods and 24 h photoperiod, can enhance sweet/less bitter taste and reduce GLS contents in swede roots, compared to growth under short day conditions. This influence of light conditions on eating quality may benefit marketing of regional products from high latitudes. © 2017 Society of Chemical Industry