bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time-frequency analysis of EEG recorded during unconscious expectation of angry vs. neutral faces in patients with major depression and healthy controls
Authors: Mnatsakanian E. , Sharaev M. , Krjukov V. , Antipova O. , Krasnov V. 
Published: June 2017

IntroductionThe knowledge on brain mechanisms of psychopathology can be very useful for the diagnosis and treatment of patients.ObjectivesPatients with major depressive disorder (MDD) show attention bias to the negative emotional stimuli. Automatic (unconscious) emotional processing in such patients may become a prospective biomarker for depression.AimsWe aimed at studying the EEG-correlates of unconscious expectation of angry human faces in MDD patients compared to healthy controls.Methods128-channel EEG was recorded in MDD (23 females and 7 males) and in healthy volunteers (22 females and 8 males) while they categorized pictures as humans or animals. Half of the pictures were neutral and half were showing the faces of angry humans or animals. The pictures were preceded by cues (one for each category), which meaning was not explained to the participants. We performed the wavelet analysis on EEG recorded during the face expectation period: 1000–2000 ms from the cue onset.ResultsWe found the emotional modulation (EM) in EEG rhythms during the expectation of angry vs. neutral faces in both groups. Statistical comparison of the spectral power using 2 × 2 factorial design showed that the EM differences (P < 0.05) between the groups were in the left parietal locations in 9 Hz and in 16–18 Hz, in the right parietal locations in 27–28 Hz, and in the right frontal area in 30–31 Hz.ConclusionsThe unconscious expectation of angry vs. neutral faces resulted in EM differences between the MDD and healthy controls in the right frontal and bilateral parietal areas mostly in beta and gamma ranges.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Trauma and the unborn child: PTSD, major depression and relationship quality following late pregnancy loss
Authors: Horesh D. , Nukrian M. , Bialik Y. 
Published: June 2017

Background and objectiveLate pregnancy loss (PL) is recognized as a very difficult life experience. Often, PL is regarded as a “feminine” trauma, experienced individually by the woman, thus neglecting the role of the parental dyad in coping with the loss. This study aimed to examine:– the prevalence of PTSD and major depressive disorder (MDD) following late PL;– the role of spousal relationship measures in vulnerability and resilience following PL.MethodsParticipants were 100 women, ages 24–49 (M = 35.07, SD = 5.28), who have experienced late PL. The mean pregnancy week of loss was 27.29, with the average woman being 22 months post-loss. 84.6% experienced stillbirth. Participants completed self-report questionnaires assessing PTSD, MDD, dyadic adjustment and dyadic self-disclosure.ResultsWe have found high rates of both PTSD (32.7%) and MDD (53%) among women following late PL, as well as high PTSD-MDD comorbidity rates. Interestingly, a negative association was found between the number of previous pregnancy losses and the severity of MDD, perhaps indicating an innoculation process. Both PTSD and MDD were negatively associated with the levels of dyadic consensus, dyadic self-disclosure regarding guilt and shame, and dyadic affectional expression.ConclusionsLate PL entails a heavy burden of PTSD and MDD, presumably since mothers are already strongly attached to their unborn child. PL is often experienced by both expecting mother and father. Thus, the quality of the spousal relationship following PL is an important protective factor. Therefore, there is a pressing need for novel interventions in couples therapy following PL.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Prevalence and related factors of postpartum depression
Authors: Sayin A.A. , Annagur B. Burcak , Annagur A. 
Published: June 2017

ObjectiveThe aim of this study was to investigate the prevalence of postpartum depression among women and determine which factors are related this clinical condition.MethodsThe study included 206 women who were admitted to the department of child health and diseases neonatal intensive care unit in Selcuk university faculty of medicine within six weeks postpartum period. First SCID-I and demographic data form for the participants who were volunteer to participate the study were filled. Then, Edinburgh postpartum depression scale, multidimensional scale of perceived social support, Beck anxiety inventory and maternal bonding scale were applied to all participants.ResultsWe found that 6.8% (n = 14) of mothers have postpartum depression. Than we compared the two grups postpartum depression (PPD) and non-postpartum depression (NPPD). In terms of socio-demographic characteristics and found a significant difference only in the level of economic status. Socio-economic status was lower in the group with PPD. In addition, social support received during pregnancy was significantly lower in the group with the PPD. Peripartum or any time depression history and comorbid psychiatric disorders were related factors with PPD. EPDS scores were significantly higher and MSPSS scores were significantly lower in the group with PPD.ConclusionPostpartum depression has many negative consequences for both mother and baby. In the present study, we found that postpartum depression rates were consistent with previous studies. Early detection, prevention and treatment of postpartum depression is very important for the postpartum women who have a higher risk for depression.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Leptin and ghrelin levels in alcohol-dependent patients and their relationship with withdrawal and craving
Authors: Mehta S. , Baruah A. , Chetia D. , Das S. , Avinash P. 
Published: June 2017

IntroductionAssociation between leptin and ghrelin plasma levels and alcohol craving have been found in few studies but they have failed to differentiate this correlation with alcohol withdrawal state.ObjectivesTo research this correlation in a different population and to study this correlation with respect to hyper-excitable state of alcohol withdrawal.AimTo study levels of leptin and ghrelin in relation with alcohol withdrawal and craving.MethodsTwenty-five indoor patients fulfilling the alcohol dependence criteria were assessed for alcohol withdrawal symptoms and craving. Leptin and ghrelin levels were measured on 1st day, @ the end of 1st week, @ the end of 3rd week of stopping alcohol. Withdrawal was assessed using CIWA-A at day 1 and day 7, craving was assessed using PENN's scale of craving at the end of week 1 and week 3. Control group consisted of 15 first-degree relatives not taking alcohol.ResultsIt was found that leptin [t (38) = 2.95, P = 0.005] and ghrelin [t (38) = 2.56, P = 0.015] were significantly higher in alcohol-dependent patients. Levels of hormones had no significant correlation with alcohol withdrawal scores but had positive correlation with craving scores after abstinence.ConclusionsLeptin and ghrelin, known for balancing the energy homeostasis of body, also seem to play a role in pathways of drug dependence and craving. This relation is independent of stress hormone axis as leptin and ghrelin levels are not correlated with withdrawal scores, which is an indicator of stress hormone axis activation during alcohol withdrawal.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Impulsivity and self-esteem in pathological gambling: What is the link?
Authors: Rogier G. , Velotti P. 
Published: June 2017

IntroductionIn empirical literature, impulsivity is identified as a core feature of gambling addiction. Furthermore, pathological gamblers are prone to have a poor self-esteem. Previous researches studied the link between impulsivity and self-esteem bringing contrasting results. However, relationships between such constructs among pathological gamblers have not been investigated.ObjectivesWe sought to explore the associations among pathological gambling, self-esteem and different facets of impulsivity comparing a clinical sample of pathological gamblers with community participants.AimsTo highlight patterns of associations between self-esteem and impulsiveness in pathological gambling.MethodsA sample of pathological gamblers and a sample of healthy men, were administered the South Oaks Gambling Screen (SOGS), the UPPS Impulsive Behavior Scale (UPPS) and the Rosenberg Self-Esteem Scale (RSES).ResultsAs expected, levels of impulsivity were significantly higher in the clinical sample while levels of self-esteem were significantly lower. A significant and negative correlation between impulsivity and self-esteem was found among pathological gamblers. Different patterns of associations were found between self-esteem and dimensions of impulsivity.ConclusionsCoherently with others results, our study confirmed that pathological gamblers showed high impulsivity and low self-esteem. The peculiars patterns of associations between impulsivity and self-esteem could be informative to tailor treatment programs for pathological gamblers.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Predictors of a suicidal behavior in patients with dementia
Authors: Maruta N. , Mudrenko I. 
Published: June 2017

IntroductionCognitive disorders are associated with a wide range of psychopathological syndromes and behavioral disorders, and suicidal manifestations in dementia are understudied nowadays.ObjectivesTo investigate clinical-psychopathological predictors of a suicidal behavior in patients with dementia.MethodologyForty-four patients with dementia were examined: 23 patients with suicidal manifestations and 21 patients without them (control group). Clinical and psychometrical methods were used: Mini Mental State Examination (MMSE) scale; Assessment of Suicide Risk scale; Hamilton Rating Scale for Depression (HDRS), and statistical ones.ResultsIt was determined that male patients with dementia had suicidal behavioral manifestations more often than female patients (69.6%; P < 0.05). An average age of the patients was 69.88 ± 1.85 years with no significant difference between the main and control groups.The majority of the patients with dementia (52.3%) had suicidal manifestations. Real suicidal intentions were the most frequent (25%; P < 0.05); 20.5% of patients expressed passive thoughts (anti-vital sentences, fantasies, ideas concerning death); 2 patients (6.82%; P < 0.05) had suicidal attempts. Patients with suicidal tendencies in their clinical picture more often had hallucinatory syndrome (39.1%; P < 0.05); features of severe depression (35.04 ± 1.54 points; P < 0.01); a high level of suicidal risk (26.34 ± 1.68 points; P < 0.01); a severe cognitive deficit (ММSE score 0–10); and a significantly lower level of self-awareness of death (18.53 ± 0.72 points; P < 0.05) in comparison with the control group.ConclusionsA high suicide risk in dementia correlated with a level of depressive symptoms (r = 0.6), moderate and/or severe grades of dementia (r = 0.45), and a low level of self-awareness of death (r = 0.35).Disclosure of interestThe authors have not supplied their declaration of competing interest.
Attentional bias toward suicide-relevant information in suicide attempters: A cross-sectional study and a meta-analysis
Authors: Richard-Devantoy S. , Yang D. , Gustavo T. , Fabrice J. 
Published: June 2017

ObjectivePrevious studies using a modified Stroop test suggested that suicide attempters, in contrast to depressed patients with no suicidal history, display a particular attentional bias toward suicide-related cues. However, negative results have also been reported. In the present study, we collected new data and pooled them as part of a meta-analysis intended to shed further light on this question.MethodWe conducted:– a cross-sectional study comparing performance on the modified Stroop task for suicide-related, positively-valenced and negatively-valenced words in 33 suicide attempters and 46 patient controls with a history of mood disorders;– a systematic review and a meta-analysis of studies comparing performance on the modified Stroop task among patients with vs. without a history of suicidal acts in mood disorders.ResultsThe cross-sectional study showed no significant difference in interference scores for any type of words between suicide attempters and patient controls. A meta-analysis of four studies, including 233 suicide attempters and 768 patient controls, showed a significant but small attentional bias toward suicide-related words (Hedges’g = 0.22; 95% CI [0.06 to 0.38]; Z = 2.73; P = 0.006), but not negatively-valenced words (Hedges’g = 0.06; 95% CI [−0.09 to 0.22]; Z = 0.77; P = 0.4) in suicide attempters compared to patient controls.LimitationsPositively-valenced words and healthy controls could not be assessed in the meta-analysis.ConclusionOur data support a selective information-processing bias among suicide attempters. Indirect evidence suggests that this effect would be state-related and may be a cognitive component of the suicidal crisis. However, we could not conclude about the clinical utility of this Stroop version at this stage.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Three dimensional versus standard miniplate fixation in the management of mandibular fractures: A meta‐analysis of randomized controlled trials
Authors: Silajiding Kubila , Wusiman Patiguli , Yusufu Bilikezi , Moming Adili 
Published: June 2017

AbstractThe aim of this meta‐analysis is to evaluate the efficacy of the 3‐dimensional miniplate system in comparison with the standard miniplate system for the treatment of mandibular fractures (MFs). A systematic review was conducted according to PRISMA guidelines, examining Medline‐Ovid, Embase, and PubMed databases. The primary search objective was to identify all papers reporting the results of randomized control trials (RCTs) for the treatment of adults with mandibular fractures, with the aim of comparing the different techniques. The incidence of complications was evaluated; nine studies including 283 patients with different fracture sites were enrolled in the analysis. The results showed no significant differences in overall complications (odds ratio [OR], 0.92; 95% confidence interval [CI], 0.552–1.542; P = 0.81), postoperative infections (OR, 0.99; 95% CI, 0.40–2.48; P = 0.89), wound dehiscence (OR, 0.96; 95% CI, 0.13–7.37; P = 0.96), paresthesia (OR, 0.47; 95% CI, 0.20–1.07; P = 0.11), or malocclusion (OR, 1.8; 95% CI, 0.39–8.32; P = 0.47) between standard miniplates and 3‐dimensional miniplates for treating mandibular fractures. Mandibular fractures treated with 3‐dimensional miniplates and standard miniplates presented similar short‐term complication rates, and the low postoperative maxillomandibular fixation rate of using standard miniplates also indicated that the standard miniplate has a promising application in the treatment of mandibular fractures.
Rapamycin‐ameliorated diabetic symptoms involved in increasing adiponectin expression in diabetic mice on a high‐fat diet
Authors: Gong Fang‐Hua , Ye Yan‐Na , Li Jin‐Meng , Zhao Hai‐Yang , Li Xiao‐Kun 
Published: June 2017

AbstractRecent studies showed that rapamycin improved diabetic complications. Here, we investigated the metabolic effects of rapamycin in type 2 diabetes model (T2DM) mice. Mice were treated with a daily intraperitoneal injection of rapamycin at 2 mg/kg or vehicle only for 3 weeks and were maintained on a high‐fat diet. The treated diabetic mice exhibited decreased body weight, blood glucose levels, and fat mass. FGF21 expression was suppressed in C57B/L6 mice, but adiponectin expression increased both in FGF21 KO and C57B/L6 mice. These results suggest that rapamycin may alleviate FGF21 resistance in mice on a high‐fat diet. The reduction of adipose tissue mass of the diabetic mice may be due to the increased adiponectin.
Polar rotor scattering as atomic-level origin of low mobility and thermal conductivity of perovskite CH3NH3PbI3
Authors: Li Bing , Kawakita Yukinobu , Liu Yucheng , Wang Mingchao , Matsuura Masato , Shibata Kaoru , Ohira-Kawamura Seiko , Yamada Takeshi , Lin Shangchao , Nakajima Kenji , Liu Shengzhong 
Published: June 2017

AbstractPerovskite CH3NH3PbI3 exhibits outstanding photovoltaic performances, but the understanding of the atomic motions remains inadequate even though they take a fundamental role in transport properties. Here, we present a complete atomic dynamic picture consisting of molecular jumping rotational modes and phonons, which is established by carrying out high-resolution time-of-flight quasi-elastic and inelastic neutron scattering measurements in a wide energy window ranging from 0.0036 to 54 meV on a large single crystal sample, respectively. The ultrafast orientational disorder of molecular dipoles, activated at ∼165 K, acts as an additional scattering source for optical phonons as well as for charge carriers. It is revealed that acoustic phonons dominate the thermal transport, rather than optical phonons due to sub-picosecond lifetimes. These microscopic insights provide a solid standing point, on which perovskite solar cells can be understood more accurately and their performances are perhaps further optimized.
A novel pH-sensitive carrier for the delivery of antitumor drugs: histidine-modified auricularia auricular polysaccharide nano-micelles
Authors: Wang Yingying , Li Pingfei , Chen Fen , Jia Lianqun , Xu Qihao , Gai Xiumei , Yu Yibin , Di Yan , Zhu Zhihong , Liang Yanyao , Liu Mengqi , Pan Weisan , Yang Xinggang 
Published: June 2017

AbstractThe study was aimed to design a novel pH-sensitive carrier to deliver antitumor drugs to increase treatment efficiency. Histidine (His)was used to modify auricularia auricular polysaccharide (AAP) by esterification. Proton nuclear magnetic resonance spectrometry was developed to characterize the His-AAP carrier and the His-AAP Paclitaxel (PTX) micelles were prepared by self-assembled organic solvent evaporation. The formation of His-AAP PTX micelles was confirmed by dynamic light-scattering, transmission electron microscopy and high performance liquid chromatography. It was found that the His-AAP PTX micelles possessed a spherical morphology with an average diameter of 157.2 nm and an 80.3% PTX encapsulation efficiency. In vitro release at pH 7.4, 6.5, 5.0 reached 70%, 71%, and 88%, respectively. The cell viability assay and confocal laser scanning microscope were used to evaluate the cytotoxicity and cell uptake of the His-AAP PTX micelles. Compared with Taxol, the IC50 of the His-AAP PTX micelles were lower after incubating for 24 h, 48 h, or 72 h (0.216 versus 0.199, 0.065 versus 0.060, and 0.023 versus 0.005, respectively). In a test of tumor-bearing mice, the His-AAP PTX micelles significantly inhibited tumor growth. These results showed that His-AAP PTX micelles are a highly promising therapeutic system for anticancer therapy.
Eosinophil Cationic Protein (ECP), a predictive marker of bullous pemphigoid severity and outcome
Authors: Giusti Delphine , Gatouillat Gregory , Le Jan Sébastien , Plée Julie , Bernard Philippe , Antonicelli Frank , Pham Bach Nga 
Published: June 2017

AbstractBullous Pemphigoid (BP) is an inflammatory rare autoimmune bullous dermatosis, which outcome cannot be predicted through clinical investigations. Eosinophils are the main immune infiltrated cells in BP. However, the release of Major Basic Protein (MBP), Eosinophil Derived Neurotoxin (EDN), and Eosinophil Cationic Protein (ECP) upon eosinophil activation has still not been evaluated with respect to BP development. MBP, EDN and ECP were measured by ELISA in serum (n = 61) and blister fluid (n = 20) of patients with BP at baseline, and in serum after 2 months of treatment (n = 41). Eosinophil activation in BP patients was illustrated at baseline by significantly higher MBP, EDN and ECP serum concentrations as compared with control subjects (n = 20), but without distinction according to disease severity or outcome. EDN and ECP values were even higher in the blister fluids (P < 0.01 and P < 0.05, respectively), whereas MBP values were lower (P < 0.001). ECP serum concentration decreased after 60 days of treatment in BP patients with ongoing remission but not in patients who later relapsed (P < 0.05). A reduction of at least 12.8 ng/mL in ECP concentrations provided a positive predictive value for remission of 81%, showing that ECP serum variation could be a useful biomarker stratifying BP patients at risk of relapse.
The gastropod shell has been co-opted to kill parasitic nematodes
Authors: Rae R. 
Published: June 2017

AbstractExoskeletons have evolved 18 times independently over 550 MYA and are essential for the success of the Gastropoda. The gastropod shell shows a vast array of different sizes, shapes and structures, and is made of conchiolin and calcium carbonate, which provides protection from predators and extreme environmental conditions. Here, I report that the gastropod shell has another function and has been co-opted as a defense system to encase and kill parasitic nematodes. Upon infection, cells on the inner layer of the shell adhere to the nematode cuticle, swarm over its body and fuse it to the inside of the shell. Shells of wildCepaea nemoralis,C. hortensisandCornu aspersumfrom around the U.K. are heavily infected with several nematode species includingCaenorhabditis elegans. By examining conchology collections I show that nematodes are permanently fixed in shells for hundreds of years and that nematode encapsulation is a pleisomorphic trait, prevalent in both the achatinoid and non-achatinoid clades of the Stylommatophora (and slugs and shelled slugs), which diverged 90–130 MYA. Taken together, these results show that the shell also evolved to kill parasitic nematodes and this is the only example of an exoskeleton that has been co-opted as an immune system.
HuR-Dependent Editing of a New Mineralocorticoid Receptor Splice Variant Reveals an Osmoregulatory Loop for Sodium Homeostasis
Authors: Lema Ingrid , Amazit Larbi , Lamribet Khadija , Fagart Jérôme , Blanchard Anne , Lombès Marc , Cherradi Nadia , Viengchareun Say 
Published: June 2017

AbstractAldosterone and the Mineralocorticoid Receptor (MR) control hydroelectrolytic homeostasis and alterations of mineralocorticoid signaling pathway are involved in the pathogenesis of numerous human diseases, justifying the need to decipher molecular events controlling MR expression level. Here, we show in renal cells that the RNA-Binding Protein, Human antigen R (HuR), plays a central role in the editing of MR transcript as revealed by a RNA interference strategy. We identify a novel Δ6 MR splice variant, which lacks the entire exon 6, following a HuR-dependent exon skipping event. Using isoform-specific TaqMan probes, we show that Δ6 MR variant is expressed in all MR-expressing tissues and cells and demonstrate that extracelullar tonicity regulates its renal expression. More importantly, this splice variant exerts dominant-negative effects on transcriptional activity of the full-length MR protein. Collectively, our data highlight a crucial role of HuR as a master posttranscriptional regulator of MR expression in response to osmotic stress. We demonstrate that hypotonicity, not only enhances MR mRNA stability, but also decreases expression of the Δ6 MR variant, thus potentiating renal MR signaling. These findings provide compelling evidence for an autoregulatory feedback loop for the control of sodium homeostasis through posttranscriptional events, likely relevant in renal pathophysiological situations.