bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract A165: Impact of travel distance and regional factors on five-year survival in gynecologic cancer patients: Analysis of National and Comprehensive Cancer Center data
Authors: Bae Sejong 
Published: September 2024

Abstract
The studies investigated the five-year survival rates of patients with cervical, ovarian, and endometrial cancers in the United States, focusing on the influence of travel distance to treatment facilities, regional differences, and the type of treatment facility. Furthermore, the impact of travel distance on five-year mortality rates was also examined specifically for patients at a Comprehensive Cancer Center. Using data from the National Cancer Database (NCDB) from 2004-2017, including only White or Black women, and additional tumor registry data from a Comprehensive Cancer Center in Alabama from 1996-2015, researchers analyzed various factors such as demographics, region, type of treatment center, distance to treatment center, and cancer stage at diagnosis. Multivariable logistic regression models were used to assess the association of travel distance with five-year mortality. Significant interactions between facility type and region on five-year survival rates. Age and cancer stage were significant factors affecting survival across all cancer types. Cervical cancer patients in the South Atlantic who traveled longer distances to Academic/Research Programs had poorer survival rates. In Alabama, median travel distances to the UAB Cancer Center varied by cancer type, with endometrial cancer patients traveling the farthest (65 miles) and cervical cancer patients the shortest (46 miles). Longer travel distances were associated with lower five-year mortality for ovarian cancer patients (OR = 0.60). These studies highlight the varied and significant impact of travel distance on cancer survival and mortality, indicating disparities in access to care. For some cancers, longer travel distances correlated with poorer outcomes, while for others, it was associated with better survival, suggesting complex underlying factors. The results underscore the need for further research to identify the causes of these disparities and to inform potential healthcare system interventions aimed at improving patient outcomes.
Citation Format: Sejong Bae. Impact of travel distance and regional factors on five-year survival in gynecologic cancer patients: Analysis of National and Comprehensive Cancer Center data [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A165.
Abstract A166: Towards Health Justice: Implementing Structural Competency in Women's Healthcare Education Towards Health Justice
Authors: Fougang Daina Charnelle , A/P Wepa Dianne Wepa , Mpofu Charles Charnelle 
Published: September 2024

Abstract
Introduction: Significant health disparities persist in women's health, particularly among marginalized groups like racial/ethnic minorities, LGBTQ+ individuals, and those with disabilities. Addressing these inequities requires training healthcare providers in structural competency to recognizing how social, economic, political, and cultural structures influence health outcomes beyond just individual factors. Objectives: The purpose of this study is to conduct a comprehensive evaluation of the literature on structural competence in connection to health inequalities in women's health. The objectives include: (1) Reviewing the role of structural competence in addressing health disparities among in reproductive health ; (2) Analysing instructional methodologies related to structural competencies; and (3) Developing a strategic framework to address racial health disparities in women's health through structural competence. Methodology: A literature review was conducted using the Scopus, Google Scholar, and Web of Science databases. After applying specific inclusion and exclusion criteria, 463 publications were retained from 905 articles published between 2010 and 2023. Findings: Major health disparities experienced by women include lack of access to quality healthcare services, discrimination from providers, higher rates of chronic illnesses, mental health issues, and lack of autonomy in reproductive health decisions and influenced by cultural norms and expectations. Racial/ethnic minority women face additional disparities due to language/cultural barriers, provider biases, impact of social determinants, and discrimination.Structural competency approaches highlighted include using community health workers (CHWs), analyzing electronic health record (EHR) data to identify disparities, advocating for policy changes targeting social determinants, and integrating structural competency training in medical curricula.While no specific successful policy examples are provided, recommendations include expanding healthcare coverage, supporting community clinics, and addressing socioeconomic inequities through systemic interventions. Conclusion: Integrating structural competency into medical education holds transformative potential for alleviating persistent health disparities in women's health by equipping providers to recognize and confront the underlying structural factors perpetuating these inequities.
Citation Format: Daina Charnelle Fougang, Dianne Wepa A/P Wepa, Charles Charnelle Mpofu. Towards Health Justice: Implementing Structural Competency in Women's Healthcare Education Towards Health Justice [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A166.
Abstract A167: Use of a culturally adapted version of the Colorectal Cancer Screening Intervention Program (CCSIP) on Black immigrants in Salt Lake City
Authors: Onigbogi Olanrewaju O. , Kah Kebba , Okuyemi Kolawole 
Published: September 2024

Abstract
Background: Colorectal Cancer (CRC) disproportionately affects Blacks in the United States (US) with an incidence rate &gt;20% compared with Whites. Genetic factors are believed to contribute as much as 35% to the overall risk of CRC. Recent male immigrants from Africa aged 45 and above may be at increased risk of developing the disease. Previous studies have reported cultural barriers in the uptake of CRC screening services in adult black immigrant populations. Therefore, providing culturally adapted versions of preventive services may be critical in reducing the disparities in cancer morbidity and mortality. The study therefore sought to evaluate the feasibility of adopting a culturally tailored CRC prevention intervention program to improve uptake among immigrants. Methods: We used the Delphi methodology to recruit a seven-man team of leaders in the African immigrant community exploring their views by administration of open-ended questions. The methodology was based on the Conducting and REporting of DElphi studies (CREDES) methodology with participants queried over three rounds about the appropriateness of a culturally adapted version of the Colorectal Cancer Screening Intervention Program (CCSIP) protocol of the National Institutes of Health (NIH). Participants also considered and gave anonymous feedback on what they perceived to be the strengths of responses of others and the findings of bigger group. This framework of expert opinion rounds was used to build the final consensus opinion. Results: There was critical consensus on the appropriateness of building trust-enhancing, fear and fatalism-reducing messages into the CCSIP protocol. There was weaker agreement on the need for religiously tailored messages. Conclusion: Improving the quality of the CCSIP protocol may be important in future interventions targeted at increasing CRC screening uptake among African immigrants.
Citation Format: Olanrewaju O. Onigbogi, Kebba Kah, Kolawole Okuyemi. Use of a culturally adapted version of the Colorectal Cancer Screening Intervention Program (CCSIP) on Black immigrants in Salt Lake City [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A167.
Abstract B009: Analysis of the KRAS mutation spectrum in Black/African American and White/European lung adenocarcinoma patients, and its association with patient survival
Authors: Mullen Daniel J , Lugo Sofia , Puente Pablo E. , Ofosu-Asante Kweku , Mensah-Mamfo Justin K. , Phillips Kyle R. , Huang Yong , Lamango Nazarius S. , Offringa Ite A. 
Published: September 2024

Abstract
Lung cancer is the most common cause of cancer-related deaths in the U.S. and its incidence and mortality rates in Black/African American (B/AA) men are 15% and 12% higher, respectively, than White/European (W/E) men. Lung adenocarcinoma is the most prevalent subtype of lung cancer in all ethnic/racial groups and is characterized by several driver mutations to genes in the RAS/RAF/MEK/ERK pathway, including KRAS. Alterations to these driver genes can vary in spectrum and frequency between ethnic/racial groups. This may influence outcomes depending on patients’ genetic backgrounds, resulting in differential response to therapy. We thus compared the frequency and spectra of mutations of the KRAS gene in B/AA and W/E patients using publicly available databases with lung adenocarcinoma (LUAD) sequencing (American Association for Cancer Research Project GENIE [Genomics Evidence Neoplasia Information Exchange], The Cancer Genome Atlas, and smaller datasets from a variety of publications). We also examined the association of the identified mutations with patient survival, with consideration of patient age, sex, and tobacco smoking history, where available. Using this information, we found that B/AA individuals had lower rates of KRAS mutations than W/E individuals. We also observed that across all patients with relevant data, those with a KRAS mutation tended to have poorer survival outcomes than those patients without. We are using information on the frequency and spectrum of KRAS mutations to develop models for lung adenocarcinoma development in B/AA patients, among others by generating isogenic cell lines carrying different KRAS mutations. Further investigations of public and published LUAD datasets are ongoing. Using the correct cell and gene models constitute a key approach to address health disparities in LUAD research and treatment.
Citation Format: Daniel J Mullen, Sofia Lugo, Pablo E. Puente, Kweku Ofosu-Asante, Justin K. Mensah-Mamfo, Kyle R. Phillips, Yong Huang, Nazarius S. Lamango, Ite A. Offringa. Analysis of the KRAS mutation spectrum in Black/African American and White/European lung adenocarcinoma patients, and its association with patient survival [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B009.
Abstract B011: FOXA1 as a pioneer factor in ERα-DNA interactions and its therapeutic potential in ER+ breast cancer: Insights from ChIP-seq and GWAS in Hispanic populations
Authors: Sharma Hemakshat , Arreola Alyssa Maria , Heredia Frances L. , Franco Hector L. , Dutil Julie 
Published: September 2024

Abstract
Forkhead box A1 (FOXA1) acts as a pioneer factor for Estrogen Receptor alpha (ERα), playing a crucial role in determining where ERα binds to DNA and regulates gene expression in breast cancer cells. A pioneer factor is a class of transcription factors (TF) that is responsible for opening the chromatin to allow other TFs to attach and activate transcription of that gene. FOXA1 acts as a facilitator for ERα-DNA interactions. It binds to specific DNA regions, opening the chromatin for ERα to bind. It “pre-marks” these sites in the genome even in the absence of estrogen. In fact, FOXA1 is frequently overexpressed in ER+ breast cancers, suggesting it has a crucial role in driving tumor growth. As such, FOXA1 is an attractive therapeutic target that already serves as a great biomarker for many types of breast cancers. Inhibiting FOXA1 can potentially block ER activity and inhibit growth of ER+ breast cancer, especially in those resistant to anti-estrogen therapies, such as tamoxifen. In this project, we identified sites that FOXA1 opens and correlated them with SNP mutations commonly found in the Hispanic population. The presence of these SNPs portends a worse outcome in Hispanic patients. To assess which open chromatin regions are crucial for breast cancer pathogenesis, a ChIP-seq analysis was done on vehicle-treated and estrogen-treated samples to determine FOXA1 binding sites. After identifying gained, lost, and differentially expressed peaks set, these were compared to genome-wide association studies (GWAS) of Hispanic patients to develop an understanding of how much overlap is common between sites of mutations and open sections of chromatin due to FOXA1. Through our analysis, we uncovered a subset of FOXA1 binding sites that overlap with sites of inherited mutation in Hispanic patients. This informs on the subset of genes that are linked to breast cancer and potential therapeutic targets.
Citation Format: Hemakshat Sharma, Alyssa Maria Arreola, Frances L. Heredia, Hector L. Franco, Julie Dutil. FOXA1 as a pioneer factor in ERα-DNA interactions and its therapeutic potential in ER+ breast cancer: Insights from ChIP-seq and GWAS in Hispanic populations [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B011.
Abstract B012: Prioritization of ancestry-specific variations in disease data helps to alleviate bias in genomic data
Authors: Smith Leslie A. , Graim Kiley , Cahill James A. 
Published: September 2024

Abstract
95% of sequencing data is from individuals of European descent. Underrepresentation of non- European individuals in genomic resources has limited our understanding of the effects of population-specific variants on complex traits and disease. Human populations have undergone selection for variants beneficial to survival in their environment, resulting in individuals with genetic variants unique to their ancestral populations. While these variants can impact disease occurrence and treatment outcome, genetic ancestry is often unaccounted for in disease modeling. Lack of ancestral population representation in data has led to disparate disease outcomes and treatment. While the primary proposed solution to this problem is more diverse sequencing of patients, these efforts will take years of effort and continual work to maintain the diversity balance. Additionally, they will not solve the issue; clinical trials cannot expect to capture human global diversity at every stage. Here we show we can mitigate data bias by utilizing readily available genomic population databases to target genes with ancestrally relevant variations. Our AI model, PhyloFrame, creates equitable gene signatures from transcriptomic input data. PhyloFrame corrects for ancestral bias in data by utilizing genomic population databases and functional interaction networks to identify genes both relevant to disease and associated with a variant unique to a single ancestry. PhyloFrame uses gnomAD data to quantify genome-wide ancestry-specific allele frequencies from a large cohort of healthy individuals, which PhyloFrame uses to create ancestry-agnostic signatures when modeling disease data. Our model demonstrates the utility of including readily available population-level data from healthy individuals in AI methods to overcome existing genomic data bias. PhyloFrame serves also as a demonstration of how equitable AI methods create gene signatures applicable across ancestries without requiring sample-specific ancestry information. Our model demonstrates how AI can be used to help mitigate ancestral bias in genomic data using preexisting data and contribute to equitable representation in medical research.
Citation Format: Leslie A. Smith, Kiley Graim, James A. Cahill. Prioritization of ancestry-specific variations in disease data helps to alleviate bias in genomic data [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B012.
Abstract B020: Do U.S. quitsites present information related to providing services for LGBTQ individuals? An audit study
Authors: Ramos Santiago Jeffrey Wilmer , McIntosh Scott , Orfin Rafael , Lara Daimarelys , Joseph Skylar , Kaur Manpreet , Ramos-Pibernus Alixida , Cupertino Ana Paula , Ossip Deborah , Cartujano-Barrera Francisco 
Published: September 2024

Abstract
This abstract is being presented as a short talk in the scientific program. A full abstract is printed in the Proffered Abstracts section (PR016) of the Conference Program/Proceedings.
Citation Format: Jeffrey Wilmer Ramos Santiago, Scott McIntosh, Rafael Orfin, Daimarelys Lara, Skylar Joseph, Manpreet Kau1, Alixida Ramos-Pibernu3, Ana Paula Cupertin1, Deborah Ossip, Francisco Cartujano-Barrera. Do U.S. quitsites present information related to providing services for LGBTQ individuals? An audit study [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B020.
Abstract B041: Community-based prostate cancer screening for Black men
Authors: Cooper Pam , Carter-Wicker Kitty , Stanley Eddie R. , Boyd Imani A. , Mavingire Nicole , Rivers Brian , Kimbro K. S. , Kittles Rick A. , Woods-Burnham Leanne 
Published: September 2024

Abstract
PURPOSE: The 5-year relative survival rate for men with prostate cancer (PC) is greater than 99% when diagnosed at an early stage. The prognosis is much worse for men diagnosed with advanced disease as there is no cure for metastatic PC. With the establishment of prostate- specific antigen (PSA) blood testing as an effective tool for early screening for PC, the prevention of morbidity and mortality from this disease proves possible. However, Black men are more likely to develop aggressive PC and die, yet less likely to be screened despite population-specific guidelines recommending shared decision-making for high-risk groups to begin at age 40. For these reasons, increasing the rate and reach of PSA screening within the community is an innovative approach to raise awareness and reduce mortality from PC for Black men. METHODS: Morehouse School of Medicine’s (MSM) Prostate Cancer Precision Prevention Program (PCP3) leverages community partnerships to provide point-of-care PSA testing at no cost to Black men in the greater Atlanta area and rural Georgia. Community-based screening events were initiated in June 2023 and have been conducted in collaboration churches, municipalities, and non-profit organizations. Participants were recruited at these events and consented to provide one tube of blood drawn by MSM phlebotomists and registered nurses for quantification of PSA levels. Results were processed through Morehouse Healthcare and participants were contacted with individual results and provided with options for follow-up. RESULTS: To date, PCP3 has conducted more than three dozen community-based screening events. Over 1000 Black men have received PSA testing with variable results. CONCLUSION: PCP3 has provided awareness and PSA testing to over 1000 Black men in Atlanta and rural Georgia at higher risk for aggressive and lethal PC. PCP3 aims to assess whether community- based screening reduces mortality from PC for Black men in Georgia over the next few years.
Citation Format: Pam Cooper, Kitty Carter-Wicker, Eddie R. Stanley, Imani A. Boyd, Nicole Mavingire, Brian Rivers, K. S. Kimbro, Rick A. Kittles, Leanne Woods-Burnham. Community-based prostate cancer screening for Black men [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B041.
Abstract B111: A needs assessment of genetic and hereditary breast cancer awareness in Southern California women diagnosed with a genetic mutation
Authors: Ruiz Dayanara 
Published: September 2024

Abstract
Background: Breast cancer is a global public health dilemma, considering the public awareness the issue has garnered over the years it continues to be diagnosed in advanced stages. Genetic mutations can increase the risk of developing breast cancer. Literature findings have identified the lack of knowledge surrounding genetic breast cancer susceptibility. Methods: In partnership with Southern California Chapter of The Breasties (SoCal Breasties), an all inclusive nonprofit organization that creates a community for survivors, previvors, thrivers, and caregivers impacted by breast and gynecological cancers, 20 women with a breast cancer related genetic mutation diagnosis were surveyed in a cross-sectional study to determine the need for health education on breast cancer genetic susceptibility. Of the 20 women surveyed, the racial/ethnic identities of the respondents is as follows: 10% identified as Asian American/Pacific Islander; 5% identified as Black; 35% identified as Hispanic/Latinx; 5% identified as “Mixed Race: Black, White”; 40% identified as White; and 5% identified as Ashkenazi Jewish, White. Results: 70% of survey respondents identified not having adequate knowledge of genetic breast cancer susceptibility prior to diagnosis. When looking at racial and ethnic groups, Black, Hispanic/Latinx, and Asian American/Pacific Islander women made up 71% of the population that lacked proper knowledge of the topic when compared to their white counterparts. 75% identified health education as the most needed resource for genetic breast cancer susceptibility. When asked to share one piece of insight, the most common sentiment expressed was “Knowledge is Power.”Conclusions: There is a need for greater health education on genetic breast cancer susceptibility, especially in racial and ethnic minority populations. Health educators and public health professionals should consider generating awareness campaigns and partnering with community based organizations to disseminate proper knowledge. In addition, resources and awareness campaigns should be culturally tailored and linguistically appropriate to meet the needs of all racial and ethnic groups.
Citation Format: Dayanara Ruiz. A needs assessment of genetic and hereditary breast cancer awareness in Southern California women diagnosed with a genetic mutation [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B111.