bluuebunny/crossref_metadata_2025_split huggingface dataset:
MicroRNA‐185 inhibits angiogenesis in human microvascular endothelial cells through targeting stromal interaction molecule 1
Authors: Hou Jiayin , Liu Liang , Zhu Qian , Wu Yingbiao , Tian Bei , Cui Li , Liu Ying , Li Xinming 
Published: December 2015

AbstractAngiogenesis is a vital biological mechanism representing the adaptive response to a variety of pathological stimuli such as hypoxia. It is regulated by several pro‐angiogenic and anti‐angiogenic microRNAs. Studies have demonstrated an altered microRNA‐185 (miR‐185) expression in endothelial cells under hypoxic conditions; however, its role in angiogenesis has not been elucidated. We investigated the role of miR‐185 in angiogenesis and found that miR‐185 had an inhibitory effect on cell proliferation, migration, and tube formation. Stromal interaction molecule 1 (STIM1) appeared to be a direct target of miR‐185 by computational prediction; this was confirmed by luciferase reporter assay. Silencing of the STIM1 gene was found to mimic miR‐185‐mediated inhibition of angiogenesis. STIM1 overexpression eliminated the anti‐angiogenic effect of miR‐185. Our study results suggest a direct interaction between miR‐185 and STIM1 mRNA in microvascular endothelial cells. MicroRNA‐185 acted as a negative regulator of angiogenesis in microvascular endothelial cells through downregulation of the STIM1 protein.
Meta‐analysis of randomized controlled trials comparing percutaneous coronary intervention with aspiration thrombectomy Vs. Conventional percutaneous coronary intervention during ST‐segment elevation myocardial infarction
Authors: Dominguez Abel Casso , Bittl John A. , El‐Hayek Georges , Contreras Elizabeth , Tamis‐Holland Jacqueline E. 
Published: December 2015

ObjectivesEvaluate the impact of aspiration thrombectomy (AT) during primary coronary intervention (PCI) for ST‐segment elevation myocardial infarction (STEMI) on clinical outcomes.BackgroundAT during PCI for STEMI may improve microvascular reperfusion, but its impact on clinical outcomes has remained controversial.MethodsWe searched Pubmed, EMBASE, Medline, Scopus, CENTRAL, andClinicalTrials.gov databases on March 31, 2015 for randomized controlled trials that evaluated the use of AT with PCI compared with PCI alone for STEMI. The primary end point was all‐cause mortality. Secondary end points included major adverse cardiac events (MACE, consisting of death, myocardial infarction, and target‐vessel revascularization), recurrent myocardial infarction (MI), target‐vessel revascularization (TVR), stent thrombosis and stroke.ResultsEighteen randomized controlled trials (n = 21,501) fulfilled the inclusion criteria. A total of 10,544 patients were treated with AT and PCI, compared to 10,957 control patients. The use of AT was not associated with a significant decrease in all‐cause mortality (RR 0.88; 95% CI 0.78–1.01; P = 0.07), MACE (RR 0.93; 95% CI 0.86‐1.00; P = 0.06), recurrent MI (RR 0.97: 95% CI 0.81–1.17; P = 0.77), TVR (RR 0.93; 95% CI 0.82–1.05; P = 0.23), stent thrombosis (RR 0.84; 95% CI 0.66–1.07; P = 0.17), or stroke (RR 1.35; 95% CI 0.86–2.11; P = 0.19).ConclusionsUsing the totality of evidence available through 2015, this meta‐analysis failed to show that the routine use of aspiration thrombectomy in patients with ST‐elevation myocardial infarction significantly reduces all‐cause mortality, MACE, recurrent MI, TVR, or stent thrombosis. The role of aspiration thrombectomy in selected patients with angiographic evidence of large thrombus burden requires further clinical investigation. © 2015 Wiley Periodicals, Inc.
Comparison of long‐term patency after endovascular therapy for superficial femoral artery occlusive disease between patients with and without hemodialysis
Authors: Matsumi Junya , Tobita Kazuki , Shishido Koki , Mizuno Shingo , Yamanaka Futoshi , Murakami Masato , Tanaka Yutaka , Takahashi Saeko , Akasaka Takeshi , Saito Shigeru 
Published: December 2015

ObjectiveTo compare long‐term patency after endovascular therapy (EVT) for superficial femoral artery (SFA) occlusive disease between patients with hemodialysis (HD; HD+) and those without HD (HD−).BackgroundLong‐term patency after EVT for SFA occlusive disease in HD+ remains unknown. Methods: EVT to SFA was successfully performed in 382 consecutive patients during 2004–2011. Cox proportional hazard model estimated the hazard ratio (HR) for the loss of primary patency (PP), secondary patency (SP), and amputation‐free survival (AFS) in HD+. Binominal logistic regression analysis calculated the propensity score (PS) for covariates with a P value of <0.2 for HD as a dependent variable. HRs were adjusted for PS in multivariate analysis using the Cox proportional hazard model.ResultsPP and SP in HD+ and HD− were 47.9 and 79.4% and 68.4 and 92.5%, respectively, 4 years after EVT. There were no procedure‐related amputations or in‐hospital deaths. Adjusted HRs for the loss of PP, SP, and AFS were as follows: loss of PP, adjusted HR 2.010, 95% CI 1.157–3.492, P = 0.013; loss of SP, adjusted HR 2.927, 95% CI 1.236–6.933, P = 0.015; and loss of AFS, adjusted HR 1.665, 95% CI 0.994–2.791, P = 0.053.ConclusionsAlthough HD+ had more than double the risks for loss of PP and SP than HD−, EVT to SFA in HD+ was found to be safe with an acceptable PP and SP. © 2015 Wiley Periodicals, Inc.
Ruthenium Nanoparticles in High‐Throughput Studies of Chemoselective Carbonyl Hydrogenation Reactions
Authors: Gmeiner Julia , Behrens Silke , Spliethoff Bernd , Trapp Oliver 
Published: December 2015

AbstractSmall (≤1.4 nm) and very active Ru nanoparticles, stabilized in a polysiloxane matrix, were prepared and studied in hydrogenation reactions by the integration of catalysis and analysis. We used our strategy to combine catalytic activity and separation selectivity in a capillary microreactor, installed in a GC–MS instrument, to develop a fast and reliable screening tool for catalysis over Ru nanoparticles. A high conversion using a low catalyst loading of 0.3 mol % and temperature and long‐term stability of the catalytically active column were observed for the hydrogenation of various carbonyl compounds, which included aldehydes, ketones, and pyruvates. Additionally, we observed a high chemoselectivity for aromatic carbonyl systems. Comprehensive measurements were performed in this high‐throughput experimental setup to gain important insights into the kinetics of hydrogenation reactions at the interface between heterogeneous and homogeneous catalysis.
Three Keggin‐Type Transition Metal‐Substituted Polyoxometalates as Pure Inorganic Photosensitizers for p‐Type Dye‐Sensitized Solar Cells
Authors: Guo Xiang‐Wei , Li Jian‐Sheng , Sang Xiao‐Jing , Chen Wei‐Lin , Su Zhong‐Min , Wang En‐Bo 
Published: December 2015

AbstractIn light of the serious challenge of severe global energy shortages, p‐type dye‐sensitized solar cells (p‐DSSCs) have attracted increasing levels of interest. The potential of three Keggin‐type transition metal‐substituted polyoxometalates, TBA8Na2[SiW9O37{Co(H2O)3}]⋅ 11 H2O (SiW9Co3), TBA4[(SiO4)W10MnIII2O36H6]⋅1.5 CH3CN⋅ 2 H2O (SiW10MnIII2), and TBA3.5H5.5[(SiO4)W10MnIII/IV2O36]⋅ 10 H2O⋅0.5 CH3CN (SiW10MnIII/IV2) has been explored as pure inorganic dye photosensitizers for p‐DSSCs (TBA=(n‐C4H9)4N+). The three dyes show overall conversion efficiencies of 0.038, 0.029, and 0.027 %, respectively, all of which are higher than that of coumarin 343 (0.017 %). These polyoxometalates are the first three pure inorganic dyes reported for use with p‐DSSCs and therefore demonstrate a new strategy for designing efficient dyes, especially pure inorganic dyes. Moreover, they broaden the range of applications for polyoxometalates.
HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat
Authors: Angelika Ihle Michaela , Merkelbach‐Bruse Sabine , Hartmann Wolfgang , Bauer Sebastian , Ratner Nancy , Sonobe Hiroshi , Nishio Jun , Larsson Olle , Åman Pierre , Pedeutour Florence , Taguchi Takahiro , Wardelmann Eva , Buettner Reinhard , Schildhaus Hans‐Ulrich 
Published: December 2015

AbstractHistone deacetylases (HDAC) are key players in epigenetic regulation of gene expression and HDAC inhibitor (HDACi) treatment seems to be a promising anticancer therapy in many human tumours, including soft tissue sarcomas. HR23b has been shown to be a potential biomarker for sensitivity to HDACi therapy in cutaneous T‐cell lymphoma and hepatocellular carcinoma. We aimed to evaluate HR23b as a candidate biomarker for HDACi response in sarcomas and gastrointestinal stromal tumours (GIST). Therefore, HR23b expression was analysed comprehensively by western blot in sarcoma and GIST cell lines covering all major clinically relevant subtypes. MTT assay and ApoTox‐GloTM Triplex assay were performed after treatment with vorinostat, belinostat, mocetinostat and entinostat. HR23b protein expression was measured under HDACi treatment. Furthermore, HR23b expression levels were immunohistochemically determined in a large set of 523 clinical samples from sarcoma and GIST patients. Western blot analyses showed that sarcomas differ significantly in their expression of HR23b protein. All HDACi were able to regulate proliferation and apoptosis in vitro. Sensitivity to vorinostat correlated significantly with HR23b protein expression. Immunohistochemical prevalence screening in clinical samples of relevant adult‐type tumours revealed that 12.5% of sarcomas (among them malignant peripheral nerve sheath tumours, pleomorphic liposarcomas, leiomyosarcomas, dedifferentiated liposarcomas, synovial sarcomas and angiosarcomas) and 23.2% of GIST show high HR23b expression. Therefore, HDACi have antiproliferative and proapoptotic effects in sarcomas depending on the expression level of HR23b. These findings suggest that HR23b represents a candidate biomarker for HDACi sensitivity in certain sarcoma types and in GIST.
N‐Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore
Authors: Roy Sudeshna , Šileikytė Justina , Neuenswander Benjamin , Hedrick Michael P. , Chung Thomas D. Y. , Aubé Jeffrey , Schoenen Frank J. , Forte Michael A. , Bernardi Paolo 
Published: December 2015

AbstractPersistent opening of the mitochondrial permeability transition pore (PTP), an inner membrane channel, leads to mitochondrial dysfunction and renders the PTP a therapeutic target for a host of life‐threatening diseases. Herein, we report our effort toward identifying small‐molecule inhibitors of this target through structure–activity relationship optimization studies, which led to the identification of several potent analogues around the N‐phenylbenzamide compound series identified by high‐throughput screening. In particular, compound 4 (3‐(benzyloxy)‐5‐chloro‐N‐(4‐(piperidin‐1‐ylmethyl)phenyl)benzamide) displayed noteworthy inhibitory activity in the mitochondrial swelling assay (EC50=280 nm), poor‐to‐very‐good physicochemical as well as in vitro pharmacokinetic properties, and conferred very high calcium retention capacity to mitochondria. From the data, we believe compound 4 in this series represents a promising lead for the development of PTP inhibitors of pharmacological relevance.
Acute respiratory infections in children and adolescents with acute lymphoblastic leukemia
Authors: Hakim Hana , Dallas Ronald , Zhou Yinmei , Pei Dequing , Cheng Cheng , Flynn Patricia M. , Pui Ching‐Hon , Jeha Sima 
Published: December 2015

BACKGROUNDKnowledge regarding the incidence, clinical course, and impact of respiratory viral infections in children with acute lymphoblastic leukemia (ALL) is limited.METHODSA retrospective cohort of patients with newly diagnosed ALL who were treated on the Total Therapy XVI protocol at St Jude Children's Research Hospital between 2007 and 2011 was evaluated.RESULTSOf 223 children, 95 (43%) developed 133 episodes of viral acute respiratory illness (ARI) (incidence, 1.1 per 1000 patient‐days). ARI without viral etiology was identified in 65 patients (29%) and no ARI was detected in 63 patients (28%). There were no significant associations noted between race, sex, age, or ALL risk group and the development of ARI. Children receiving induction chemotherapy were found to be at the highest risk of viral ARI (incidence, 2.3 per 1000 patient‐days). Influenza virus was the most common virus (38%) followed by respiratory syncytial virus (33%). Of 133 episodes of viral ARI, 61% of patients were hospitalized, 26% experienced a complicated course, 80% had their chemotherapy delayed, and 0.7% of patients died. Twenty‐four patients (18%) developed viral lower respiratory tract infections (LRTI), 5 of whom (21%) had complications. Patients with viral LRTI had a significantly lower nadir absolute lymphocyte count; were sicker at the time of presentation; and were more likely to have respiratory syncytial virus, to be hospitalized, and to have their chemotherapy delayed for longer compared with those with viral upper respiratory tract infections.CONCLUSIONSDespite the low incidence of viral ARI in children with ALL, the associated morbidity, mortality, and delay in chemotherapy remain clinically significant. Viral LRTI was especially associated with high morbidity requiring intensive care‐level support. Cancer 2016;122:798–805. © 2015 American Cancer Society.
A high‐order local time stepping finite volume solver for one‐dimensional blood flow simulations: application to the ADAN model
Authors: Müller Lucas O. , Blanco Pablo J. , Watanabe Sansuke M. , Feijóo Raúl A. 
Published: December 2015

SummaryIn recent years, the complexity of vessel networks for one‐dimensional blood flow models has significantly increased, because of enhanced anatomical detail or automatic peripheral vasculature generation, for example. This fact, along with the application of these models in uncertainty quantification and parameter estimation poses the need for extremely efficient numerical solvers. The aim of this work is to present a finite volume solver for one‐dimensional blood flow simulations in networks of elastic and viscoelastic vessels, featuring high‐order space‐time accuracy and local time stepping (LTS). The solver is built on (i) a high‐order finite volume type numerical scheme, (ii) a high‐order treatment of the numerical solution at internal vertexes of the network, often called junctions, and (iii) an accurate LTS strategy. The accuracy of the proposed methodology is verified by empirical convergence tests. Then, the resulting LTS scheme is applied to arterial networks of increasing complexity and spatial scale heterogeneity, with a number of one‐dimensional segments ranging from a few tens up to several thousands and vessel lengths ranging from less than a millimeter up to tens of centimeters, in order to evaluate its computational cost efficiency. The proposed methodology can be extended to any other hyperbolic system for which network applications are relevant. Copyright © 2016 John Wiley & Sons, Ltd.
Efficient bit‐parallel subcircuit extraction using CUDA
Authors: Hung Che‐Lun , Lin Chun‐Yuan , Ou Chia‐Shin , Tseng Yuan‐Hong , Hung Po‐Yen , Li Ship‐Peng , Fu Chun‐Ting 
Published: December 2015

SummaryWafer processing technology has been improving rapidly. Moore's law has been exceeded as the number of transistors in a dense integrated circuit, now increases threefold or more, approximately every year. The integrated circuit has gone from very large scale to giga large scale. The extraction of subcircuits has therefore become computation‐intensive. In this paper, we propose an efficient bit‐parallel subcircuit extraction algorithm using graphic processing units. We conducted experimental trials and demonstrated that the proposed algorithm can achieve high throughput, suggesting practical applications in the extraction of subcircuits. Copyright © 2015 John Wiley & Sons, Ltd.
Qespera: an adaptive framework for prediction of queue waiting times in supercomputer systems
Authors: Murali Prakash , Vadhiyar Sathish 
Published: December 2015

SummaryProduction parallel systems are space‐shared, and resource allocation on such systems is usually performed using a batch queue scheduler. Jobs submitted to the batch queue experience a variable delay before the requested resources are granted. Predicting this delay can assist users in planning experiment time‐frames and choosing sites with less turnaround times and can also help meta‐schedulers make scheduling decisions. In this paper, we present an integrated adaptive framework, Qespera, for prediction of queue waiting times on parallel systems. We propose a novel algorithm based on spatial clustering for predictions using history of job submissions and executions. The framework uses adaptive set of strategies for choosing either distributions or summary of features to represent the system state and to compare with history jobs, varying the weights associated with the features for each job prediction, and selecting a particular algorithm dynamically for performing the prediction depending on the characteristics of the target and history jobs. Our experiments with real workload traces from different production systems demonstrate up to 22% reduction in average absolute error and up to 56% reduction in percentage prediction error over existing techniques. We also report prediction errors of less than 1 h for a majority of the jobs. Copyright © 2015 John Wiley & Sons, Ltd.
Exploiting multi‐cores for efficient interchange of large messages in distributed systems
Authors: Zhao Dongfang , Qiao Kan , Zhou Zhou , Li Tonglin , Zhou Xiaobing , Raicu Ioan 
Published: December 2015

SummaryConventional data serialization tools assume that objects to be coded are usually small in size so a single CPU core can encode it in a timely manner. In the era of Big Data, however, object gets increasingly complex and larger, which makes data serialization become a new performance bottleneck. This paper describes an approach to parallelize data serialization by leveraging multiple cores. Parallelizing data serialization introduces new questions such as how to split the (sub)objects, how to allocate the available cores, and how to minimize its overhead in practice. In this paper we design a framework for parallelly serializing large objects and analyze the design tradeoffs under different scenarios. To validate the proposed approach, we implemented parallel protocol buffers—the parallel version of Google's Protocol Buffers, a widely‐used data serialization utility. Experimental results confirm the effectiveness of Parallel Protocol Buffers: multiple cores employed in data serialization achieve highly scalable performance and incur negligible overhead. Copyright © 2015 John Wiley & Sons, Ltd.
Co‐conformational Exchange Triggered by Molecular Recognition in a Di(acylamino)pyridine‐Based Molecular Shuttle Containing Two Pyridine Rings at the Macrocycle
Authors: Martinez‐Cuezva Alberto , Carro‐Guillen Fernando , Pastor Aurelia , Marin‐Luna Marta , Orenes Raul‐Angel , Alajarin Mateo , Berna Jose 
Published: December 2015

AbstractWe describe the incorporation of endo‐pyridine units into the tetralactam ring of di(acylamino)pyridine‐based rotaxanes. This macrocycle strongly associates with the linear interlocked component as confirmed by X‐ray diffraction studies of rotaxane 2 b. Dynamic NMR studies of 2 b in solution revealed a rotational energy barrier that was higher than that of the related rotaxane 2 a, which lacks of pyridine rings in the macrocycle. The macrocycle distribution of the molecular shuttle 4 b, containing two endo‐pyridine rings, shows that the major co‐conformer is that with the cyclic component sitting over the di(acylamino)pyridine station. DFT calculations also support the marked preference of the ring for occupying the heterocyclic binding site. The association of N‐hexylthymine with the di(acylamino)pyridine binding site of 4 b led to the formation of a rare ‘S’‐shaped co‐conformer in which the tetralactam ring interacts simultaneously with both stations of the thread.
A High Voltage Olivine Cathode for Application in Lithium‐Ion Batteries
Authors: Di Lecce Daniele , Brescia Rosaria , Scarpellini Alice , Prato Mirko , Hassoun Jusef 
Published: December 2015

AbstractA new olivine composition (i.e., LiFe0.25Mn0.5Co0.25PO4) is proposed as electrode material with increased energy density for application in lithium‐ion batteries. The new formulation increases the working voltage and induces different electrochemical behavior with respect to bare olivine materials based on Fe. The study provides deep insight into the features of the Fe3+/Fe2+, Mn3+/Mn2+, and Co3+/Co2+ redox couples within the olivine lattice in terms of electrochemical activity, Li+ transport properties, and Li‐cell behavior. The electrochemical characterization clearly reveals the voltage signatures corresponding to the various metals; however, the Mn3+/Mn2+ process has higher intrinsic polarization with respect to Fe3+/Fe2+ and Co3+/Co2+. This issue is efficiently mitigated by carbon coating the material, resulting in enhanced electrochemical performances.
Towards catchment classification in data‐scarce regions
Authors: Auerbach Daniel A. , Buchanan Brian P. , Alexiades Alexander V. , Anderson Elizabeth P. , Encalada Andrea C. , Larson Erin I. , McManamay Ryan A. , Poe Gregory L. , Walter M.Todd , Flecker Alexander S. 
Published: December 2015

AbstractAssessing spatial variation in hydrologic processes can help to inform freshwater management and advance ecological understanding, yet many areas lack sufficient flow records on which to base classifications. Seeking to address this challenge, we apply concepts developed in data‐rich settings to public, global data in order to demonstrate a broadly replicable approach to characterizing hydrologic variation. The proposed approach groups the basins associated with reaches in a river network according to key environmental drivers of hydrologic conditions. This initial study examines Colorado (USA), where long‐term streamflow records permit comparison with previously distinguished flow regime types, and Ecuador, where data limitations preclude such analysis. The flow regime types assigned to gages in Colorado corresponded reasonably well to the classes distinguished from environmental features. The divisions in Ecuador reflected major known biophysical gradients while also providing a higher resolution supplement to an existing depiction of freshwater ecoregions. Although freshwater policy and management decisions occur amidst uncertainty and imperfect knowledge, this classification framework offers a rigorous and transferrable means to distinguish catchments in data‐scarce regions. The maps and attributes of the resulting ecohydrologic classes offer a departure point for additional study and data collection programmes such as the placement of stations in under‐monitored classes, and the divisions may serve as a preliminary template with which to structure conservation efforts such as environmental flow assessments. Copyright © 2015 John Wiley & Sons, Ltd.