bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between occlusal force distribution in implant overdenture prostheses and residual ridge resorption
Authors: Khuder T. , Yunus N. , Sulaiman E. , Ibrahim N. , Khalid T. , Masood M. 
Published: March 2017

SummaryThis study aimed to investigate residual ridge resorption (RRR) of anterior and posterior maxillary and mandibular edentulous ridges, in patients treated with mandibular implant overdentures (IOD) and compare with conventional complete denture (CD) wearers, and to determine at each location, the association of RRR with the occlusal forces distribution and other patients’ variables. The anterior and posterior RRR of IOD (six males, 17 females) and CD (12 males, 11 females) groups were determined using baseline and follow‐up dental panaromic radiographs (DPT) (mean intervals 4 ± 1·8 years). The bone ratios were calculated using proportional area: anatomic to fixed reference areas and mean difference of ratios between the intervals determined RRR. The ridge locations included anterior and posterior maxillary and posterior mandibular arches. The T‐Scan III digital occlusal system was used to record anterior and posterior percentage occlusal force (%OF) distributions. There were significant differences in anterior and posterior %OF between treatment groups. Two‐way anova showed RRR was significant for arch locations (P = 0·005), treatment group (IOD versus CD) (P = 0·001), however, no significant interaction (P = 0·799). Multivariate regression analyses showed significant association between RRR and %OF at anterior maxilla (P = 0·000) and posterior mandible (P = 0·023) and for treatment groups at posterior maxilla (P = 0·033) and mandibular areas (P = 0·021). Resorption was observed in IOD compared to CD groups, with 8·5% chance of less resorption in former and 7·8% in the latter location. Depending on arch location, ridge resorption at various locations was associated with occlusal force distribution and/or treatment groups (implant prostheses or conventional complete dentures).
Immunohistochemical detection of Mycoplasma salivarium in oral lichen planus tissue
Authors: Mizuki Harumi , Abe Ryosuke , Kogi Shintaro , Mikami Toshinari 
Published: March 2017

BackgroundOral lichen planus (OLP) is a T‐cell‐mediated inflammatory disease; however, its exact etiology is unknown. Hyperkeratosis is often observed in OLP lesions. Previous studies have revealed the localization of Mycoplasma salivarium in the epithelial cells of oral leukoplakia with hyperkeratosis. Herein, we investigated the presence of M. salivarium in OLP tissue by immunohistochemistry to determine the causative factor of OLP.MethodsForty‐one formalin‐fixed, paraffin‐embedded samples obtained from 31 patients with OLP were examined. Ten samples of normal‐appearing oral mucosa were used as controls. Immunohistochemistry (IHC) was performed using anti‐M. salivarium monoclonal antibodies.Results and ConclusionsMycoplasma salivarium was detected in the epithelium and lymphocyte infiltrate area in 24 of 41 OLP samples (58.5%). The bacteria were intracellularly localized in epithelial cells, while it was unclear whether they were also localized in lymphocyte cells or in the extracellular spaces among the lymphocytes in the subepithelial lymphocyte infiltrate area. Little or no staining was observed in the epithelium in the normal‐appearing mucosa samples. Sawtooth rete ridge formation was observed in 21 OLP samples (51.2%), and a significant positive correlation between sawtooth rete ridge formation and IHC positivity was demonstrated. However, the role of M. salivarium in the epithelium and lamina propria of OLP tissue remains unknown.
Pathogenic Variability within Indian Alternaria brassicae Isolates Using Seed, Cotyledon and Leaf of Brassica Species
Authors: Meena Prabhu Dayal , Gupta Riteka , Meena Hari Singh , Sharma Pankaj , Jambhulkar Sanjay 
Published: March 2017

AbstractThirty Alternaria brassicae (Berk.) Sacc. isolates from diverse geographical locations of India were studied for pathogenic variability on seed, cotyledon and true leaves of Brassica species. Seed germination was reduced maximum by isolate BAB‐39 in Brassica juncea cultivar Varuna (22.1%), Brassica rapa var. Toria cultivar PT‐303 (12%), Brassica carinata cultivar Kiran (12%), Brassica napus cultivar GSL‐1 (11%) and tolerant source of B. juncea genotype PHR‐2 (7%), although least by isolate BAB‐49. Maximum lesion size on leaf was recorded in B. juncea cultivar Rohini (11.2, 16.5 and 16.8 mm) with isolates BAB‐09 (Pantnagar), BAB‐19 (Bharatpur) and BAB‐39 (Kangra), respectively, and categorized as highly virulent, while minimum lesion size of 3.2, 3.7 and 3.8 mm was observed with isolates BAB‐47 (Tonk), BAB 49 (Jobner) and BAB 04 (Kamroop), respectively, considered the weak isolates. On B. alba, BAB‐09, BAB‐19 and BAB‐39 isolates caused maximum lesion size of 3.7, 3.8 and 3.9 mm, respectively, even though it showed maximum tolerance. In both seed and cotyledon inoculation method, the per cent Alternaria blight severity above 80% was observed with isolate of BAB‐39 (91.5%), BAB‐19 (89.0%), BAB‐09 (85.5%) and least in isolate BAB‐49 (34.0%). Brassica seed, cotyledon and leaf showed the similar positive response for categorizing A. brassicae isolates as virulent and avirulent. This information could be used to the development and assessment of resistant brassica germplasm, especially with A. brassicae populations exhibiting increased virulence.
Clinical findings and results of diagnostic imaging in 82 dogs with gastrointestinal ulceration
Authors: Fitzgerald E. , Barfield D. , Lee K. C. L. , Lamb C. R. 
Published: March 2017

ObjectivesTo describe clinical and imaging findings in dogs with confirmed gastrointestinal ulceration, to compare findings in dogs with perforated and non‐perforated ulcers and to estimate the sensitivities of radiography, ultrasonography and computed tomography (CT) for gastrointestinal ulceration and perforation.MethodsRetrospective review of medical records of 82 dogs that had a macroscopic ulcer in the gastric or intestinal mucosa diagnosed directly at endoscopy, surgery or necropsy and had survey radiography, ultrasonography or aCTscan of the abdomen during the same period of hospitalisation.ResultsThe most frequent clinical signs were vomiting in 88% dogs, haematemesis in 32%, melaena in 31% and weight loss in 7%. The most frequent imaging findings in dogs with non‐perforated ulcers were gastrointestinal mural lesion in 56%, mucosal defect compatible with an ulcer in 44% and peritoneal fluid in 21%. In dogs with perforated ulcers the most frequent imaging findings were peritoneal fluid in 83%, gastrointestinal mural lesion in 48%, peritoneal gas in 31% and mucosal defect compatible with an ulcer in 29%. Sensitivities of radiography, ultrasonography andCTwere 30, 65 and 67% in dogs with non‐perforated ulcers and 79, 86 and 93% in dogs with perforated ulcers, respectively.Clinical SignificanceIn dogs with non‐perforated ulcers, survey radiography was usually negative whereas ultrasonography andCTfrequently enabled detection of the site of the ulcer; in dogs with perforated ulcers, radiography was frequently positive for peritoneal gas andCTwas a sensitive modality for both the ulcer and signs of perforation.
Malignant anal sac melanoma in dogs: eleven cases (2000 to 2015)
Authors: Vinayak A. , Frank C. B. , Gardiner D. W. , Thieman‐Mankin K. M. , Worley D. R. 
Published: March 2017

ObjectivesTo report the signalment, clinical presentation, treatments pursued and outcomes of dogs with malignant anal sac melanoma.MethodsMedical records from five institutions from January 2000 through December 2015 were reviewed and dogs with cytologically‐ or histologically‐confirmed malignant anal sac melanoma were identified. Signalment, clinical signs, staging, cytology, histopathologic analysis, surgical and non‐surgical treatments were extracted from the medical records. The referring veterinarians and owners were contacted for follow‐up data.ResultsEleven dogs were included and survival data was available for all. The most common clinical signs were bloody anal sac discharge and perianal licking. Initial treatments pursued included surgery (n=8), chemotherapy (n=1), and palliative treatment with pain medications and stool softeners (n=2). In an adjuvant setting, melanoma vaccine was pursued following surgery in three dogs and chemotherapy in one dog. Regardless of treatment, progression‐free survival (mean 92 · 5 days) and overall survival times (median 107 days) were short.Clinical SignificanceDogs in this case series had a guarded to poor prognosis regardless of treatment. Ten of 11 dogs were euthanased due to local or distant disease progression. Only 1 of 11 dogs was alive one year after diagnosis. An understanding of tumour behaviour in this location could lead to improved survival times with earlier diagnosis and treatment.
Combined tibial plateau levelling osteotomy and lateral fabellotibial suture for cranial cruciate ligament rupture with severe rotational instability in dogs
Authors: Schaible M. , Shani J. , Caceres A. , Payton M. , Segev Y. , Ben‐Amotz R. 
Published: March 2017

ObjectiveTo report the use of tibial plateau levelling osteotomy and lateral fabellotibial suture in combination for treatment of severe internal tibial rotational stifle instability in cranial cruciate‐deficient stifles.MethodsTwenty‐three stifles in 19 dogs were diagnosed with cranial cruciate ligament rupture with severe stifle instability, characterised by marked cranial tibial translation and internal tibial rotation that was evident during orthopaedic examination. A combined tibial plateau levelling osteotomy and lateral fabellotibial suture procedure were performed to stabilise the stifle joint. The surgical complications, short‐term lameness scores and owner satisfaction were evaluated.ResultsThe postoperative complication rate was 21
·
7% with one minor (4
·
3%) and four major (17
·
4%) complications. At short‐term follow‐up one dog had an intermittent low‐grade lameness and two dogs had mild tibial internal rotational instability present on palpation without lameness. Owner's overall satisfaction with the operation and recovery was good (21
·
4%) to excellent (78
·
6%).Clinical SignificanceThe use of lateral fabellotibial suture in combination with tibial plateau levelling osteotomy was an effective technique for managing cranial cruciate ligament rupture with severe internal tibial rotational stifle instability.
Petrographic and geochemical evidence for multiphase formation of carbonates in the Martian orthopyroxenite Allan Hills 84001
Authors: Moyano‐Cambero Carles E. , Trigo‐Rodríguez Josep M. , Benito M. Isabel , Alonso‐Azcárate Jacinto , Lee Martin R. , Mestres Narcís , Martínez‐Jiménez Marina , Martín‐Torres Francisco J. , Fraxedas Jordi 
Published: March 2017

AbstractMartian meteorites can provide valuable information about past environmental conditions on Mars. Allan Hills 84001 formed more than 4 Gyr ago, and owing to its age and long exposure to the Martian environment, and this meteorite has features that may record early processes. These features include a highly fractured texture, gases trapped during one or more impact events or during formation of the rock, and spherical Fe‐Mg‐Ca carbonates. In this study, we have concentrated on providing new insights into the context of these carbonates using a range of techniques to explore whether they record multiple precipitation and shock events. The petrographic features and compositional properties of these carbonates indicate that at least two pulses of Mg‐ and Fe‐rich solutions saturated the rock. Those two generations of carbonates can be distinguished by a very sharp change in compositions, from being rich in Mg and poor in Fe and Mn, to being poor in Mg and rich in Fe and Mn. Between these two generations of carbonate is evidence for fracturing and local corrosion.
Pathology of toxic leucoencephalopathy in drug abuse supports hypoxic‐ischemic pathophysiology/etiology
Authors: Alturkustani Murad , Ang Lee‐Cyn , Ramsay David 
Published: March 2017

The histopathological features of leucoencephalopathy caused by illicit drugs (such as opioids and cocaine) are well documented in acute cases but not in long‐survival cases. There are several hypotheses about the pathogenesis of this disorder, including hypoperfusion, direct drug toxicity resulting from the neurotoxic effects of the drug itself or contaminants in the illicit drug vehicle. We reviewed the post mortem findings in five males (aged 24 to 56 years, with survival intervals ranging from 7 days to 5 months) with a history of illicit drug use and concomitant fatal white matter changes. The histological characteristics of leucoencephalopathy vary with survival period. Prominent axonal injury and axonal spheroids were observed with shorter survival and spongiform changes becoming apparent with longer survival (acute and chronic incomplete infarct pattern). Necrosis was present in all cases and its appearance changed with longer survival (acute and chronic complete infarct pattern). Significant primary demyelination was not observed. These observations suggest that the primary defect in this leucoencephalopathy is hypoxic‐ischemic injury, predominantly in the white matter. Spongiform leucoencephalopathy likely represents the longer‐survival incomplete infarct pattern and is observed with polydrug abuse.
Real‐time detection of N‐end rule‐mediated ubiquitination via fluorescently labeled substrate probes
Authors: Mot Augustin C. , Prell Erik , Klecker Maria , Naumann Christin , Faden Frederik , Westermann Bernhard , Dissmeyer Nico 
Published: March 2017

Summary

The N‐end rule pathway has emerged as a major system for regulating protein functions by controlling their turnover in medical, animal and plant sciences as well as agriculture. Although novel functions and enzymes of the pathway have been discovered, the ubiquitination mechanism and substrate specificity of N‐end rule pathway E3 ubiquitin ligases have remained elusive. Taking the first discovered bona fide plant N‐end rule E3 ligase PROTEOLYSIS1 (PRT1) as a model, we used a novel tool to molecularly characterize polyubiquitination live, in real time.

We gained mechanistic insights into PRT1 substrate preference and activation by monitoring live ubiquitination using a fluorescent chemical probe coupled to artificial substrate reporters. Ubiquitination was measured by rapid in‐gel fluorescence scanning as well as in real time by fluorescence polarization.

The enzymatic activity, substrate specificity, mechanisms and reaction optimization of PRT1‐mediated ubiquitination were investigated ad hoc instantaneously and with significantly reduced reagent consumption.

We demonstrated that PRT1 is indeed an E3 ligase, which has been hypothesized for over two decades. These results demonstrate that PRT1 has the potential to be involved in polyubiquitination of various substrates and therefore pave the way to understanding recently discovered phenotypes of prt1 mutants.
Long‐term hypovitaminosis D and secondary hyperparathyroidism outcomes of the Roux‐en‐Y gastric bypass: a systematic review
Authors: Switzer N. J. , Marcil G. , Prasad S. , Debru E. , Church N. , Mitchell P. , Billington E. O. , Gill R. S. 
Published: March 2017

SummaryIntroductionPre‐operative Vitamin D deficiency is markedly prevalent in prospective bariatric surgery patients. While bariatric surgery leads to significant weight loss, it can exacerbate or prolong Vitamin D deficiency. We systematically reviewed the literature to assess whether secondary hyperparathyroidism is maintained in the medium to long term in patients following the Roux‐en‐Y gastric bypass.MethodsA comprehensive literature search was conducted through Medline, Embase, Scopus, Web of Science, Dare, Cochrane library and HTA database. The search terms used were bariatric surgery, gastric bypass and hyperparathyroidism.ResultsFourteen studies were included (n = 2688 subjects). Parathyroid hormone levels rose gradually from a mean pre‐operative level of 5.69 ± 1.2 pmol/L to 6.36 ± 0.77 pmol/L, 7.59 ± 0.73 pmol/L and 8.29 ± 1.41 pmol/L at 2 years, between 2 and 5 years, and beyond 5 years, respectively. Vitamin D levels slowly fell to a mean of 20.50 ± 4.37 ng/mL and 20.76 ± 3.80 ng/mL between follow‐up intervals 2–5 years and beyond 5, respectively.ConclusionIt appears that hyperparathyroidism persists at 5‐year follow‐up after gastric bypass, despite most patients being supplemented with calcium and Vitamin D.
Intravenous Zoledronic Acid 5 mg on Bone Turnover Markers and Bone Mineral Density in East China Subjects with Newly Diagnosed Osteoporosis: A 24‐month Clinical Study
Authors: Liang Bo‐cheng , Shi Zhen‐yu , Wang Bo , Wu Peng , Kong Ling‐cheng , Yao Jian‐liang , Li Chun‐wen , Shi Xiao‐lin 
Published: March 2017

ObjectiveThis randomized, double‐blind, placebo‐controlled study assessed the necessity of early intervention, safety and efficacy of intravenous zoledronic acid 5 mg/year in East China women with newly diagnosed osteoporosis at high risk of fracture during a 24‐month treatment period.MethodsSubjects (57 [52–62] years old) were randomized 3:2 to zoledronic acid versus placebo (randomized at baseline, zoledronic acid [175 cases], placebo‐zoledronic acid [110 cases]). The bone mineral density of the lumbar spine and total hip was measured every 6 months with the use of dual‐energy X‐ray absorptiometry. Serum procollagen I N‐terminal pro‐peptide (PINP) and serum C‐telopeptide of type I collagen (CTX) levels were measured every 6 months. The primary end point was the rate of change in the bone mineral density at the posteroanterior spine.ResultsFor subjects with measurements at 24 months, zoledronic acid significantly increased bone mineral density (BMD) at the lumbar spine (mean percent change ± SD, zoledronic acid 5.390% ± 0.854% versus placebo‐zoledronic acid −1.038% ± 0.599%), the total hip (zoledronic acid 1.900% ± 0.262% versus placebo–zoledronic acid −1.631% ± 0.649%). Serum procollagen I N‐terminal pro‐peptide (PINP) and CTX decreased rapidly with zoledronic acid 5 mg treatment (P < 0.001 versus placebo at 6 month and 24 months) and changed from baseline in the zoledronic acid 5 mg and placebo–zoledronic acid 5 mg at 6 months by a mean of −66.348% and −75.375%, respectively (P < 0.001), and at 24 months by −49.950% and −52.325%, respectively (P < 0.001). No cases of serious adverse events were observed in two groups. Headache, pyrexia and myalgia occurred more commonly within the first 3 days after infusion with zoledronic acid 5 mg than with placebo (13.7% versus 2.1%, P = 0.0018; 28.0% versus 3.2%, P < 0.001; 21.7% versus 4.2%, P < 0.001, respectively).ConclusionsThese data show that early application of zoledronic acid 5 mg/year was well stimulated and tolerated for bone mass in newly diagnosed east china subjects with osteoporosis in a 24‐month treatment.
5q14.3 Microdeletions: A Contiguous Gene Syndrome with Capillary Malformation–Arteriovenous Malformation Syndrome and Neurologic Findings
Authors: Park Sung‐Min , Kim Jeong‐Min , Kim Gun‐Wook , Kim Hoon‐Soo , Kim Byung‐Soo , Kim Moon‐Bum , Ko Hyun‐Chang 
Published: March 2017

AbstractDeletions within chromosome region 5q14.3q15 have been associated with a spectrum of disorders including developmental delay, hypotonia, absent speech, mild facial dysmorphism, seizures, and brain anomalies. Some cases of concomitant neurologic abnormalities and cutaneous vascular malformation associated with 5q14.3 deletion have been reported. Previously reported cases had similar features, including multiple capillary malformations, and neurologic abnormalities, including epilepsy, hypotonia, and developmental delay. We report a case of 5q14.3 neurocutaneous syndrome presenting with multiple capillary malformations, neurologic abnormalities, and microdeletion in chromosome 5q14.3.
Humor in romantic relationships: A meta‐analysis
Authors: HALL JEFFREY A. 
Published: March 2017

AbstractThis manuscript reports a meta‐analysis of the correlation between humor and relationship satisfaction in romantic relationships, combining 43 distinct samples from 39 manuscripts and including 15,177 participants (54.7% female) with a mean age of 34.0 years. Drawing from 3 theoretical dimensions of humor (i.e., within‐person/relational, positive/negative, instrumental/content free), weighted mean effect sizes were estimated for 12 distinct subdimensions of humor. All 6 positive types of humor were positively associated with relationship satisfaction, and 4 of 5 negative types of humor were negatively associated with relationship satisfaction. Instrumental humor was unassociated with satisfaction. In support of the proposed relational dimension, self‐reported humor showed small associations with satisfaction, while partner‐perceived and relational humor showed medium and large effect sizes, respectively.
Experiences and needs of spouses of persons with young‐onset frontotemporal lobe dementia during the progression of the disease
Authors: Johannessen Aud , Helvik Anne‐Sofie , Engedal Knut , Thorsen Kirsten 
Published: March 2017

BackgroundTwo of the most common types of young‐onset dementia (<65 years old) are Alzheimer's disease and frontotemporal lobe dementia (FTLD). A limited amount of research that focuses on the needs of spouses of persons with young‐onset FTLD (yo‐FTLD) has been published. Thus, we have carried out a study aiming to examine the spouses of yo‐FTLD experiences and needs for assistance in daily life.MethodQualitative interviews with 16 informants (aged 51–69 years; nine wives, six husbands and one male cohabitant) were conducted in 2014 and 2015. The data were analysed by reformulated and modified method of Grounded Theory.FindingsFrom the interviews, three main themes with subthemes emerged: The first main theme that appeared is sneaking signs at the early stage of dementia. It covers two subthemes: incomprehensible early signs and lack of self‐insight. The second main theme that appeared is other relations, and it covers three subthemes: the torment, interference with work and vanishing social relations. The third main theme: needs for assistance through all stages of dementia, are described under three subthemes: Relief of the diagnosis, support at home and the path to the nursing home.ConclusionThe interviews showed that spouses and the whole family of yo‐FTLD need interdisciplinary, individualised and specialised support throughout the progression of the disorder. Furthermore, there is a need for more knowledge about yo‐FTLD among health personnel, including general practitioners. IT‐solutions can contribute to developing such services and support to the entire family.