bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can synaptophysin be used as a marker of breast cancer diagnosed by core‐needle biopsy in epithelial proliferative diseases of the breast?
Authors: Maeda Ichiro , Tajima Shinya , Ariizumi Yasushi , Doi Masatomo , Endo Akira , Naruki Saeko , Hoshikawa Masahiro , Koizumi Hirotaka , Kanemaki Yoshihide , Ueno Takahiko , Tsugawa Koichiro , Takagi Masayuki 
Published: May 2016

AbstractThe differential diagnosis of epithelial proliferative disease using core needle biopsy (CNB) is problematic because it is difficult to differentiate between intraductal papilloma, ductal hyperplasia, ductal carcinoma in situ, and invasive ductal carcinoma. Many studies have reported that breast cancer lesions are positive for neuroendocrine (NE) markers, whereas only a small number of studies have reported immunopositivity for NE markers in normal mammary tissues or benign lesions. We asked whether NE factors could be used as markers of breast cancer. We determined the immunopositivity rate of synaptophysin, an NE marker, in 204 lesions excised from the breast using CNB in patients who visited a university‐affiliated comprehensive medical facility and examined whether synaptophysin is a marker of breast cancer. The specimens were classified as synaptophysin‐negative cases (56 benign, 99 malignant); equivocal cases (<1 %: 2 benign, 15 malignant); and synaptophysin‐positive cases (1 benign, 31 malignant). The sensitivity, specificity, positive predictive value, and negative predictive value for malignancy of the lesions classified as synaptophysin positive were 23.3 %, 98.2 %, 96.9 %, and 36.1 %, respectively. The respective values for lesions classified as equivocal were 11.6 %, 96.6 %, 88.2 %, and 36.1 %. Synaptophysin may provide a marker of breast cancer diagnosed by CNB.
Parental Infertility, Fertility Treatment, and Childhood Epilepsy: A Population‐Based Cohort Study
Authors: Kettner Laura O. , Ramlau‐Hansen Cecilia H. , Kesmodel Ulrik S. , Bay Bjørn , Matthiesen Niels B. , Henriksen Tine B. 
Published: May 2016

AbstractBackgroundA few studies have indicated an increased risk of epilepsy in children conceived by fertility treatment possibly due to characteristics of the infertile couple rather than the treatment. We therefore aimed to investigate the association between parental infertility, fertility treatment, and epilepsy in the offspring, including the subtypes of epilepsy; idiopathic generalised epilepsy and focal epilepsy.MethodsThis cohort included all pregnancies resulting in liveborn singletons from the Aarhus Birth Cohort, Denmark (1995–2013). Information on time to pregnancy and fertility treatment was obtained from pregnancy questionnaires in early pregnancy. Children developing epilepsy were identified from the Danish National Patient Register and the Danish National Prescription Registry until 2013. Data were analysed using Cox proportional hazards regression adjusted for potential confounders.ResultsA total of 60 440 pregnancies were included, and 0.8% of the children developed epilepsy.The primary analyses showed no association between parental infertility or fertility treatment, and the overall risk of childhood epilepsy (hazard rate ratios (HRs); 95% confidence intervals (CIs): 1.08 (0.73, 1.60) and 1.04 (0.71, 1.52)). In secondary analyses, both parental infertility and fertility treatment were associated with an increased risk of idiopathic generalised epilepsy (HRs and 95% CIs: 2.25 (1.10, 4.58) and 2.45 (1.26, 4.75)). No association was seen for focal epilepsy.ConclusionParental infertility or fertility treatment was not associated with an overall risk of childhood epilepsy. Parental infertility may be associated with an increased risk of idiopathic generalised epilepsy; a subtype of epilepsy believed to be of genetic origin.
Public Revenue‐Expenditure Nexus in South Africa: Are there Asymmetries?
Authors: Baharumshah Ahmad Zubaidi , Jibrilla Aliyu Alhaji , Sirag Abdalla , Ali Hamisu Sadi , Muhammad Ibrahim Muye 
Published: May 2016

AbstractThis paper re‐examines the government revenue and expenditure relationship in South Africa using Enders and Siklos' Threshold adjustment and Granger causality tests. The paper allows for structural breaks in the unit root and cointegration tests. The results indicate the absence of any asymmetries in both the threshold autoregression and momentum threshold autoregression specifications of adjustments in the South African's budgeting process. The estimated symmetric error‐correction models provide support for the fiscal synchronization hypothesis of government revenues and expenditures for long‐run and short‐run dynamic equilibrium. These findings indicate that the South African fiscal authorities should try to maintain or even improve the control of their fiscal policy instruments to sustain the prudent budgetary process.
Latin as a split‐DPlanguage
Authors: Giusti Giuliana , Iovino Rossella 
Published: May 2016

AbstractIn this paper, we discuss known and less known properties of Latin Nominal Expressions that apparently create a paradox. Despite lack of articles and high productivity in left branch extraction, Latin is not a typicalNP‐language in the sense of Chierchia () and Bošković (,). In many respects, it behaves like its daughter languages, all of which have articles. We solve this paradox proposing a complex nominal structure made of aDP, which hosts overt demonstratives, and a left‐peripheral projection (LPP), parallel to the splitCPin clauses. This splitDP, based on Giusti (,), can account both for the freedom of the orders found inside the Nominal Expression and for the occurrence of discontinuous Nominal Expressions.
Discourse level variable licensing.Par exemplein Quebec French
Authors: Isac Daniela , Petitclerc Laurence 
Published: May 2016

AbstractThis paper reports the existence of a type of lexical item that has gone unnoticed in the previous literature. We start from the observation that the phrasepar exemplein Quebec French has two possible meanings: an illustrative one and a contrastive one. We argue that contrastivepar exempleadjoins to constituents that are similar to polarity sensitive items and thus marks sensitivity of the respective XP to a certain property of the environment. The syntactic distribution of the XP to which contrastivepar exempleadjoins to, although similar to that of polarity sensitive items, actually differs from the latter in important respects. Just like polarity sensitive items, the [XPpar exemple] constituent must be in the scope of an operator. However, unlike polarity sensitive items, which are licensed by operators that are defined at sentence level, the licensor of contrastive [XPpar exemple] is a discourse level connector (i.e. a connector that relates the sentence that containspar exemplewith a previous, independently expressed sentence). This implies that discourse connectors do more than simply relate two propositions: given that they also licence variables, they also have operator properties.
Disseminated Hormographiella aspergillata infection with involvement of the lung, brain, and small intestine following allogeneic hematopoietic stem cell transplantation: case report and literature review
Authors: Nanno S. , Nakane T. , Okamura H. , Nishimoto M. , Koh H. , Nakamae H. , Ohsawa M. , Yarita K. , Kamei K. , Hino M. 
Published: May 2016

AbstractDisseminated infection by Hormographiella aspergillata is extremely rare and small intestine involvement has not been reported previously. A 51‐year‐old man with myelodysplastic syndrome developed pneumonia after cord blood cell transplantation. Fungal growth from the biopsied lung was identified as H. aspergillata by morphology and the gene analysis. Although antifungal agents including voriconazole and liposomal amphotericin B were administered, he died of disseminated H. aspergillata infection. We review the literature and discuss the treatment and prognosis.
Targeting of blood safety measures to affected areas with ongoing local transmission of malaria
Authors: Domanović D. , Kitchen A. , Politis C. , Panagiotopoulos T. , Bluemel J. , Van Bortel W. , Overbosch D. , Lieshout‐Krikke R. , Fabra C. , Facco G. , Zeller H. 
Published: May 2016

SUMMARYAn outbreak of locally acquired Plasmodium vivax malaria in Greece started in 2009 and peaked in 2011. Targeting of blood safety measures to affected areas with ongoing transmission of malaria raised questions of how to define spatial boundaries of such an area and when to trigger any specific blood safety measures, including whether and which blood donation screening strategy to apply. To provide scientific advice the European Centre for Disease Prevention and Control (ECDC) organised expert meetings in 2013. The outcomes of these consultations are expert opinions covering spatial targeting of blood safety measures to affected areas with ongoing local transmission of malaria and blood donation screening strategy for evidence of malaria infection in these areas. Opinions could help EU national blood safety authorities in developing a preventive strategy during malaria outbreaks.
Fetal RHD genotyping after bone marrow transplantation
Authors: Thurik Florentine F. , Page‐Christiaens Godelieve C.M.L. , Ait Soussan Aicha , Ligthart Peter C. , Cheroutre Goedele M.A.F. , Bossers Bernadette , Veldhuisen Barbera , van der Schoot C. Ellen , de Haas Masja 
Published: May 2016

BACKGROUNDFetal RHD genotyping allows targeted diagnostic testing, fetal surveillance, and eventually intrauterine treatment to D‐alloimmunized pregnant women who carry an RHD+ fetus. However, false‐positive and false‐negative results of noninvasive prenatal fetal RHD genotyping have been described due to a variety of causes. In this case report we present two cases where noninvasive fetal RHD typing was complicated by a previous bone marrow transplantation (BMT).CASE REPORTWe describe two women with a history of allogeneic BMT in early childhood. Both were born D+ and received a transplant of their D– male sibling. Anti‐D were detected during pregnancy in one of them. The biologic father of this pregnancy was D+. In both cases polymerase chain reaction procedures specific for RHD on maternal plasma DNA were positive whereas a D– neonate was born in one case (Case 1).CONCLUSIONFalse‐positive results of noninvasive fetal RHD genotyping occur in D+ women transplanted with marrow of a D– donor, due to circulating cell‐free DNA originating from nonhematopoietic tissue. The cases highlight that health care professionals and laboratories should be aware that allogeneic BMT can be a cause for false‐positive results in fetal RHD genotyping with cell‐free DNA in maternal plasma, and likewise the wrong fetal sex can be reported in the case of a male donor and a female fetus. Based on one of the cases we also recommend giving D– blood products to young female patients who receive a BMT of D– donors.
Comparison between point‐of‐care dermatophyte test medium and mycology laboratory culture for diagnosis of dermatophytosis in dogs and cats
Authors: Kaufmann Ronnie , Blum Shlomo E. , Elad Daniel , Zur Gila 
Published: May 2016

BackgroundPoint‐of‐care Dermatophyte Test Medium (PoC‐DTM) is a diagnostic procedure to rule in/rule out dermatophytosis in veterinary clinics.ObjectiveTo evaluate the performance of PoC‐DTM in the clinic compared to DTM plate culture in a mycology laboratory and to compare results obtained by general practitioners and referral clinicians.AnimalsHair samples were collected from 47 cats and 54 dogs with suspected dermatophytosis and from nine healthy controls (seven cats and two dogs).MethodsThis was a multicentre blinded study. In one group (65 suspected cases, 9 healthy controls), PoC‐DTM results were evaluated by clinicians in a referral clinic (SP group) who examined the colony morphology macroscopically and microscopically. In the other group (36 suspected cases) PoC‐DTM results were evaluated by clinicians from general practice for colour change only, with no macroscopic or microscopic examination (GP group). All hair samples were also cultured on DTM plates in a mycology laboratory. Laboratory culture was considered the gold standard for comparison.ResultsAgreements between tests were 97% (two false positive; κ = 0.839) and 80.6% (five false positives and two false negatives; κ = 0.466) in the SP and GP groups, respectively. This difference between groups was significant (P = 0.024).Conclusion and clinical importanceWhen applying macroscopic and microscopic evaluation of the colony, PoC‐DTM is accurate for diagnosing dermatophytes with only a 3% chance of error. However, when macroscopic and microscopic examination is not included there is significant (19.4%) chance for an incorrect diagnosis.
Variants in genes belonging to the fibroblast growth factor family are associated with lower extremity amputation in non‐Hispanic whites: Findings from the chronic renal insufficiency cohort study
Authors: Gupta Jayanta , Mitra Nandita , Townsend Raymond R. , Fischer Michael , Schelling Jeffrey R. , Margolis David J. 
Published: May 2016

AbstractDiabetes is the major risk factor for nontraumatic lower extremity amputation (LEA). The role of genetic polymorphisms in predisposing diabetics to impaired wound healing leading to LEA has not been sufficiently explored. We investigated the association between a set of genes belonging to the angiogenesis/wound repair pathway with LEA in the Chronic Renal Insufficiency Cohort, a study of adults with chronic kidney disease (CKD) that includes a subgroup with diabetes. This study was performed on 3,772 Chronic Renal Insufficiency Cohort participants who were genotyped on the ITMAT‐Broad‐CARe array chip. A total of 1,017 single‐nucleotide polymorphisms (SNPs) in 22 genes belonging to the angiogenesis/would repair pathway were investigated. LEA was determined from patient self‐report. The association between genetic variants and LEA status was examined using logistic regression and additive genetic models after stratifying the cohort by race/ethnicity and diabetic status. Unadjusted analyses as well as analyses adjusted for age, sex, estimated glomerular filtration rate, body mass index, peripheral vascular disease, hemoglobin A1c, and population stratification were performed. In non‐Hispanic white participants with diabetes, rs11938826 and rs1960669, both intronic SNPs in the gene basic fibroblast growth factor‐2 (FGF2), were significantly associated with LEA in covariate‐adjusted analysis (OR: 2.83 (95% CI: 1.73, 4.62); p‐value: 0.000034; Bonferroni adjusted p‐value: 0.0006) and (OR: 2.61 (95% CI: 1.48, 4.61); p‐value: 0.00095; Bonferroni adjusted p‐value: 0.02). In the same subgroup, rs10883688, an FGF8 SNP of unknown functional effect, was also associated with LEA (OR: 1.72 (95% Confidence Interval: 1.14, 2.6); p‐value: 0.00999; Bonferroni adjusted p‐value: 0.04). No statistically significant associations were identified in the other ethnic groups. In conclusion, variant/s in FGF2 and FGF8 may predispose diabetics with CKD to LEA. Dysregulation of the FGF2 gene represents an opportunity to understand further, and possibly intervene upon, mechanisms of wound healing in diabetics with CKD.
Ciprofloxacin‐loaded keratin hydrogels reduce infection and support healing in a porcine partial‐thickness thermal burn
Authors: Roy Daniel C. , Tomblyn Seth , Isaac Kameel M. , Kowalczewski Christine J. , Burmeister David M. , Burnett Luke R. , Christy Robert J. 
Published: May 2016

AbstractInfection is a leading cause of morbidity and mortality in burn patients. Current therapies include silver‐based creams and dressings, which display limited antimicrobial effectiveness and impair healing. The need exists for a topical, point‐of‐injury antibiotic treatment that provides sustained antimicrobial activity without impeding wound repair. Fitting this description are keratin‐based hydrogels, which are fully biocompatible and support the slow‐release of antibiotics. Here we develop a porcine model of an infected partial‐thickness burn to test the effects of ciprofloxacin‐loaded keratin hydrogels on infection and wound healing. Partial‐thickness burns were inoculated with either Pseudomonas aeruginosa or Methicillin‐resistant Staphylococcus aureus, resulting in infections that persisted for >2 weeks that exceeded 105 and 106 cfu per gram of tissue, respectively. Compared to silver sulfadiazine, ciprofloxacin‐loaded keratin hydrogel treatment significantly reduced the amount of P. aeruginosa and S. aureus in the burn by >99% on days 4, 7, 11, and 15 postinjury. Further, burns treated with ciprofloxacin‐loaded keratin hydrogels exhibited similar healing patterns as uninfected burns with regards to reepithelialization, macrophage recruitment, and collagen deposition and remodeling. The ability of keratin hydrogels to deliver antibiotics to fight infection and support healing of partial‐thickness burns make them a strong candidate as a first‐line burn therapy.
ENHANCING TEMPERATURE CONTROL METHOD OF THERMAL VACUUM CHAMBER FOR SATELLITE TESTING USING OPTIMIZATION ALGORITHM: A REVIEW
Authors: Salleh Nor’asnilawati , Mohd Daud Salwani , Fadlie Sabri Sharizal , Ahmad@Salleh Noor Azurati , Shariff Sya Azmeela , Md Yusof Yusnaidi , Adam Mohamad Zulkefli 
Published: May 2016

This paper studies a comparison of optimization algorithms to enhance temperature control method of thermal vacuum chamber (TVC) for satellite testing. The gaseous nitrogen (GN2) is used in TVC to control the temperature requirement and proportional integral derivative (PID) controller is adopted in order to realize it. However, the temperature profile is fluctuated and more time is needed before it managed to achieve the temperature set point. Therefore, a study is done to identify the algorithms that can be applied to optimize the temperature control system of TVC. The study is aim to improve the current temperature control in terms of settling time and overshoot. The method used in the review is by comparing the optimization algorithms that have been used to optimize the temperature control system. The study will be done using other related works that had been done by other researchers. From the review that has been done, the genetic algorithm (GA) is believed to be the best method that can be implemented into the temperature control system of TVC. In the future, the study will further analyse by using simulation tools and real time data generated by the TVC.
THE COMPARATIVE PERFORMANCE EVALUATION OF WINDOW FUNCTIONS UNDER NOISY ENVIRONMENT FOR SPEECH RECOGNITION
Authors: Nafisah Syifaun , Wahyunggoro Oyas , Nugroho Lukito Edi 
Published: May 2016

The accuracy and user acceptance of speech recognition systems is increasing in the last few years especially for automated identification and biomedical applications. In implementation, it works based on the feature of utterance that will be recognized through a feature extraction process. One process in feature extraction is windowing that is done for minimizing the disruptions at the first and last of the frame. Basically, many window functions exist such as rectangular window, flat top window, hamming window, etc, but in the real application only hamming or Hanning function that are usually used as a function in the windowing. This article will analyzed the performance of all of window functions to prove the performance of those function. The method that was used are mel-frequencies cepstral coefficients (MFCCs) as feature extractor technique and back propagation neural networks (BPNNs) as classifier. The result shows that it can produce an accuracy at least 99%. The optimal accuracy up to 99.86% is achieved using rectangle window with the duration of process is 15.47 msec. This results show the superior performance of rectangle window as reference to recognize an isolated word based on speech.
PERFORMANCE EVALUATION OF TRANSMISSION FOR MULTIUSER MIMO BROADCAST CHANNEL
Authors: Idris Mohd Syarhan , Abdul Razak Nur Idora , Idris Azlina , Ab Rahman Ruhani 
Published: May 2016

Multiple Input Multiple Output (MIMO) system has been brought a great improvement in spectral efficiency and the system capacity by serving multiple users simultaneously. The mathematical model of downlink Multi-user MIMO system and its capacity has been presented as well as different precoded transmission schemes. It is to implementing the downlink MU-MIMO system, such as channel inversion (CI), block diagonalization (BD), dirty paper coding (DPC) and tomlinsonharashimaprecoding (THP). It is because, in wireless and mobile communication system has been requires a reliable transmission of high data rates under various channel type different scenarios and reduce MU interference in the system. These compares the method of transmission for broadcast channel (BC) and propose the best one method that outperforms existing technique with percentage improvement from the worst performance.
HYBRID ACTIVE POWER FILTER METHOD IN FREQUENCY DOMAIN FOR QUALITY IMPROVEMENT IN VARIABLE FREQUENCY DRIVE APPLICATIONS
Authors: Hac Le Minh Hoang , Nguyen Kim-Anh , Ngo Viet Hung 
Published: May 2016

We present in this paper a control method of a novel hybrid parallel active power filter (HPAPF) used for harmonic currents elimination and reactive power compensation in the power system for three-phase variable frequency drives (VFDs). The HPAPF configuration is built from two filter components including harmonics tuned passive filter and active power electronics filter. The active power electronics filter of the proposed HPAPF system is controlled by a novel control algorithm that makes use of Fourier analysis to facilitate accurate selective harmonics targeting allowing the cooperation between passive and active components. In the proposed topology, a coupling of the passive filter component and the active filter allows significant reduction in current rating of the active filter component. This rating reduction scheme implies a great economic advantage of the proposed HPAPF compared to the methods which are based only on traditional pure active power electronics filters. The hardware design and the control algorithm of the proposed HPAPF are verified by MATLAB/Simulink software.
HARDWARE DESIGN AND IMPLEMENTATION OF GENETIC ALGORITHM FOR THE CONTROLLER OF A DC TO DC BOOST CONVERTER
Authors: Yap Roderick , Lam Kevin , Bugayong Rovi , Hernandez Edward , De Guzman Joey 
Published: May 2016

Controllers for DC to DC Boost Converters have evolved from simple control method to those that involve the use of fuzzy logic controllers. In many implementations, Proportional Integral Derivative (PID) controllers are commonly employed. In this paper, a genetic algorithm for tuning the PID controller of a DC to DC Boost Converter is hardware modelled and implemented on a Field Programmable Gate Array (FPGA) using Verilog as tool for the design entry. The goal of embedding genetic algorithm into the controller is to search for the best PID parameters that will yield fast settling time of the booster at an output of 6V. The hardware implementation allows the controller to tune itself by searching for the best Kp, Ki and Kd values that will give the best settling time. Significantly, this eliminates the need for a separate computer to do the searching routine. Test results of the circuit implemented yielded promising results. When compared to previous researches, the genetic algorithm employed yielded good PID parameters that resulted to a settling time as low as less than 60msec.