bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study on sensing property of one-dimensional ring mirror-defect photonic crystal
Authors: Chen Ying , Luo Pei , Cao Huiying , Zhao Zhiyong , Zhu Qiguang 
Published: November 2017

Based on the photon localization and the photonic bandgap characteristics of photonic crystals (PCs), one-dimensional (1D) ring mirror-defect photonic crystal structure is proposed. Due to the introduction of mirror structure, a defect cavity is formed in the center of the photonic crystal, and then the resonant transmission peak can be obtained in the bandgap of transmission spectrum. The transfer matrix method is used to establish the relationship model between the resonant transmission peak and the structure parameters of the photonic crystals. Using the rectangular air gate photonic crystal structure, the dynamic monitoring of the detected gas sample parameters can be achieved from the shift of the resonant transmission peak. The simulation results show that the Q-value can attain to 1739.48 and the sensitivity can attain to 1642 nm ⋅ RIU[Formula: see text], which demonstrates the effectiveness of the sensing structure. The structure can provide certain theoretical reference for air pollution monitoring and gas component analysis.
DS++
Authors: Dym Nadav , Maron Haggai , Lipman Yaron 
Published: November 2017

Correspondence problems are often modelled as quadratic optimization problems over permutations. Common scalable methods for approximating solutions of these NP-hard problems are the spectral relaxation for non-convex energies and the doubly stochastic (DS) relaxation for convex energies. Lately, it has been demonstrated that semidefinite programming relaxations can have considerably improved accuracy at the price of a much higher computational cost.
We present a convex quadratic programming relaxation which is provably stronger than both DS and spectral relaxations, with the same scalability as the DS relaxation. The derivation of the relaxation also naturally suggests a projection method for achieving meaningful integer solutions which improves upon the standard closest-permutation projection. Our method can be easily extended to optimization over doubly stochastic matrices, injective matching, and problems with additional linear constraints. We employ recent advances in optimization of linear-assignment type problems to achieve an efficient algorithm for solving the convex relaxation.
We present experiments indicating that our method is more accurate than local minimization or competing relaxations for non-convex problems. We successfully apply our algorithm to shape matching and to the problem of ordering images in a grid, obtaining results which compare favorably with state of the art methods.
We believe our results indicate that our method should be considered the method of choice for quadratic optimization over permutations.
Fast gaze-contingent optimal decompositions for multifocal displays
Authors: Mercier Olivier , Sulai Yusufu , Mackenzie Kevin , Zannoli Marina , Hillis James , Nowrouzezahrai Derek , Lanman Douglas 
Published: November 2017

As head-mounted displays (HMDs) commonly present a single, fixed-focus display plane, a conflict can be created between the vergence and accommodation responses of the viewer. Multifocal HMDs have long been investigated as a potential solution in which multiple image planes span the viewer's accommodation range. Such displays require a scene decomposition algorithm to distribute the depiction of objects across image planes, and previous work has shown that simple decompositions can be achieved in real-time. However, recent optimal decompositions further improve image quality, particularly with complex content. Such decompositions are more computationally involved and likely require better alignment of the image planes with the viewer's eyes, which are potential barriers to practical applications.
Our goal is to enable interactive optimal decomposition algorithms capable of driving a vergence- and accommodation-tracked multifocal testbed. Ultimately, such a testbed is necessary to establish the requirements for the practical use of multifocal displays, in terms of computational demand and hardware accuracy. To this end, we present an efficient algorithm for optimal decompositions, incorporating insights from vision science. Our method is amenable to GPU implementations and achieves a three-orders-of-magnitude speedup over previous work. We further show that eye tracking can be used for adequate plane alignment with efficient image-based deformations, adjusting for both eye rotation and head movement relative to the display. We also build the first binocular multifocal testbed with integrated eye tracking and accommodation measurement, paving the way to establish practical eye tracking and rendering requirements for this promising class of display. Finally, we report preliminary results from a pilot user study utilizing our testbed, investigating the accommodation response of users to dynamic stimuli presented under optimal decomposition.
Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats
Authors: Nakamori Hiroyuki , Naitou Kiyotada , Horii Yuuki , Shimaoka Hiroki , Horii Kazuhiro , Sakai Hiroki , Yamada Akihiro , Furue Hidemasa , Shiina Takahiko , Shimizu Yasutake 
Published: November 2017

Colorectal motility is regulated by two defecation centers located in the brain and spinal cord. In previous studies, we have shown that administration of serotonin (5-HT) in the lumbosacral spinal cord causes enhancement of colorectal motility. Because spinal 5-HT is derived from neurons of the medullary raphe nuclei, including the raphe magnus, raphe obscurus, and raphe pallidus, we examined whether stimulation of the medullary raphe nuclei enhances colorectal motility via the lumbosacral defecation center. Colorectal pressure was recorded with a balloon in vivo in anesthetized rats. Electrical stimulation of the medullary raphe nuclei failed to enhance colorectal motility. Because GABAergic neurons can be simultaneously activated by the raphe stimulation and released GABA masks accelerating actions of the raphe nuclei on the lumbosacral defecation center, a GABAA receptor antagonist was preinjected intrathecally to manifest excitatory responses. When spinal GABAA receptors were blocked by the antagonist, electrical stimulation of the medullary raphe nuclei increased colorectal contractions. This effect of the raphe nuclei was inhibited by intrathecal injection of 5-hydroxytryptamine type 2 (5-HT2) and type 3 (5-HT3) receptor antagonists. In addition, injection of a selective 5-HT reuptake inhibitor in the lumbosacral spinal cord augmented the raphe stimulation-induced enhancement of colorectal motility. Transection of the pelvic nerves, but not transection of the colonic nerves, prevented the effect of the raphe nuclei on colorectal motility. These results demonstrate that activation of the medullary raphe nuclei causes augmented contractions of the colorectum via 5-HT2 and 5-HT3 receptors in the lumbosacral defecation center. NEW & NOTEWORTHY We have shown that electrical stimulation of the medullary raphe nuclei causes augmented contractions of the colorectum via pelvic nerves in rats. The effect of the medullary raphe nuclei on colorectal motility is exerted through activation of 5-hydroxytryptamine type 2 and type 3 receptors in the lumbosacral defecation center. The descending serotoninergic raphespinal tract represents new potential therapeutic targets against colorectal dysmotility such as irritable bowel syndrome.
Prefrontal cortical-specific differences in behavior and synaptic plasticity between adolescent and adult mice
Authors: Konstantoudaki Xanthippi , Chalkiadaki Kleanthi , Vasileiou Elisabeth , Kalemaki Katerina , Karagogeos Domna , Sidiropoulou Kyriaki 
Published: November 2017

Adolescence is a highly vulnerable period for the emergence of major neuropsychological disorders and is characterized by decreased cognitive control and increased risk-taking behavior and novelty-seeking. The prefrontal cortex (PFC) is involved in the cognitive control of impulsive and risky behavior. Although the PFC is known to reach maturation later than other cortical areas, little information is available regarding the functional changes from adolescence to adulthood in PFC, particularly compared with other primary cortical areas. This study aims to understand the development of PFC-mediated, compared with non-PFC-mediated, cognitive functions. Toward this aim, we performed cognitive behavioral tasks in adolescent and adult mice and subsequently investigated synaptic plasticity in two different cortical areas. Our results showed that adolescent mice exhibit impaired performance in PFC-dependent cognitive tasks compared with adult mice, whereas their performance in non-PFC-dependent tasks is similar to that of adults. Furthermore, adolescent mice exhibited decreased long-term potentiation (LTP) within upper-layer synapses of the PFC but not the barrel cortex. Blocking GABAA receptor function significantly augments LTP in both the adolescent and adult PFC. No change in intrinsic excitability of PFC pyramidal neurons was observed between adolescent and adult mice. Finally, increased expression of the NR2A subunit of the N-methyl-d-aspartate receptors is found only in the adult PFC, a change that could underlie the emergence of LTP. In conclusion, our results demonstrate physiological and behavioral changes during adolescence that are specific to the PFC and could underlie the reduced cognitive control in adolescents. NEW & NOTEWORTHY This study reports that adolescent mice exhibit impaired performance in cognitive functions dependent on the prefrontal cortex but not in cognitive functions dependent on other cortical regions. The current results propose reduced synaptic plasticity in the upper layers of the prefrontal cortex as a cellular correlate of this weakened cognitive function. This decreased synaptic plasticity is due to reduced N-methyl-d-aspartate receptor expression but not due to dampened intrinsic excitability or enhanced GABAergic signaling during adolescence.
Impact of spatiotemporal calcium dynamics within presynaptic active zones on synaptic delay at the frog neuromuscular junction
Authors: Homan Anne E. , Laghaei Rozita , Dittrich Markus , Meriney Stephen D. 
Published: November 2017

The spatiotemporal calcium dynamics within presynaptic neurotransmitter release sites (active zones, AZs) at the time of synaptic vesicle fusion is critical for shaping the dynamics of neurotransmitter release. Specifically, the relative arrangement and density of voltage-gated calcium channels (VGCCs) as well as the concentration of calcium buffering proteins can play a large role in the timing, magnitude, and plasticity of release by shaping the AZ calcium profile. However, a high-resolution understanding of the role of AZ structure in spatiotemporal calcium dynamics and how it may contribute to functional heterogeneity at an adult synapse is currently lacking. We demonstrate that synaptic delay varies considerably across, but not within, individual synapses at the frog neuromuscular junction (NMJ). To determine how elements of the AZ could contribute to this variability, we performed a parameter search using a spatially realistic diffusion reaction-based computational model of a frog NMJ AZ (Dittrich M, Pattillo JM, King JD, Cho S, Stiles JR, Meriney SD. Biophys J 104: 2751–2763, 2013; Ma J, Kelly L, Ingram J, Price TJ, Meriney SD, Dittrich M. J Neurophysiol 113: 71–87, 2015). We demonstrate with our model that synaptic delay is sensitive to significant alterations in the spatiotemporal calcium dynamics within an AZ at the time of release caused by manipulations of the density and organization of VGCCs or by the concentration of calcium buffering proteins. Furthermore, our data provide a framework for understanding how AZ organization and structure are important for understanding presynaptic function and plasticity. NEW & NOTEWORTHY The structure of presynaptic active zones (AZs) can play a large role in determining the dynamics of neurotransmitter release across many model preparations by influencing the spatiotemporal calcium dynamics within the AZ at the time of vesicle fusion. However, less is known about how different AZ structural schemes may influence the timing of neurotransmitter release. We demonstrate that variations in AZ structure create different spatiotemporal calcium profiles that, in turn, lead to differences in synaptic delay.
Blood Pressure Status in Adult Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study
Authors: Gibson Todd M. , Li Zhenghong , Green Daniel M. , Armstrong Gregory T. , Mulrooney Daniel A. , Srivastava DeoKumar , Bhakta Nickhill , Ness Kirsten K. , Hudson Melissa M. , Robison Leslie L. 
Published: November 2017

Abstract
Background: Hypertension potentiates cardiovascular risk in survivors of childhood cancer previously exposed to cardiotoxic therapies, so it is important to determine the prevalence and risk factors for hypertensive blood pressure in this high-risk group.
Methods: Participants included 3,016 adult 10-year survivors of childhood cancer who had resting blood pressure measurements performed at St. Jude Children's Research Hospital (Memphis, TN). We characterized the blood pressure status of participants, calculated standardized prevalence ratios based on U.S. population rates, and examined demographic and treatment factors associated with hypertensive blood pressure using logistic regression.
Results: The age-specific cumulative prevalence of hypertension in survivors increased sharply with age, exceeding 70% by age 50, and was substantially higher in all diagnosis groups than expected on the basis of age-, sex-, race/ethnicity-, and BMI-specific population rates. Specific cancer treatments were not significantly associated with hypertension, with the exception of nephrectomy (OR, 1.68; 95% confidence interval, 1.11–2.53). Previously undiagnosed hypertensive blood pressure was identified in 8% of survivors, and uncontrolled hypertension in 22% of those with a previous hypertension diagnosis. In a subset (n = 1,185) with longitudinal blood pressure measurements (mean interval, 3.6 years), 5% and 21% of participants with previously normal blood pressure developed hypertensive and prehypertensive blood pressure, respectively.
Conclusions: Survivors of childhood cancer have a higher prevalence of hypertension compared with the general population, and many have uncontrolled hypertension that may exacerbate treatment-related cardiovascular risks.
Impact: Our results suggest enhanced clinical attention to blood pressure status is warranted in all survivors, regardless of diagnosis or cancer treatment. Cancer Epidemiol Biomarkers Prev; 26(12); 1705–13. ©2017 AACR.
Real-World Use of Apixaban for Stroke Prevention in Atrial Fibrillation
Authors: Proietti Marco , Romanazzi Imma , Romiti Giulio Francesco , Farcomeni Alessio , Lip Gregory Y.H. 
Published: November 2017

Background and Purpose—
The use of oral anticoagulant therapy for stroke prevention in atrial fibrillation has been transformed by the availability of the nonvitamin K antagonist oral anticoagulants. Real-world studies on the use of nonvitamin K antagonist oral anticoagulants would help elucidate their effectiveness and safety in daily clinical practice. Apixaban was the third nonvitamin K antagonist oral anticoagulants introduced to clinical practice, and increasing real-world studies have been published. Our aim was to summarize current evidence about real-world studies on apixaban for stroke prevention in atrial fibrillation.

Methods—
We performed a systematic review and meta-analysis of all observational real-world studies comparing apixaban with other available oral anticoagulant drugs.

Results—

From the original 9680 results retrieved, 16 studies have been included in the final meta-analysis. Compared with warfarin, apixaban regular dose was more effective in reducing any thromboembolic event (odds ratio: 0.77; 95% confidence interval: 0.64–0.93), but no significant difference was found for stroke risk. Apixaban was as effective as dabigatran and rivaroxaban in reducing thromboembolic events and stroke. The risk of major bleeding was significantly lower for apixaban compared with warfarin, dabigatran, and rivaroxaban (relative risk reduction, 38%, 35%, and 46%, respectively). Similarly, the risk for intracranial hemorrhage was significantly lower for apixaban than warfarin and rivaroxaban (46% and 54%, respectively) but not dabigatran. The risk of gastrointestinal bleeding was lower with apixaban when compared with all oral anticoagulant agents (
P
<0.00001 for all comparisons).

Conclusions—
Use of apixaban in real-life is associated with an overall similar effectiveness in reducing stroke and any thromboembolic events when compared with warfarin. A better safety profile was found with apixaban compared with warfarin, dabigatran, and rivaroxaban.
Prehospital Systolic Blood Pressure Is Related to Intracerebral Hemorrhage Volume on Admission
Authors: Rodriguez-Luna David , Rodriguez-Villatoro Noelia , Juega Jesús M. , Boned Sandra , Muchada Marián , Sanjuan Estela , Pagola Jorge , Rubiera Marta , Ribo Marc , Coscojuela Pilar , Molina Carlos A. 
Published: November 2017

Background and Purpose—
Ultra-early blood pressure (BP) management in the prehospital setting could improve the efficacy of this treatment on attenuating intracerebral hemorrhage (ICH) expansion. We aimed to determine the association of prehospital systolic BP (SBP) with ICH volume, ultra-early hematoma growth, and the spot sign on admission.

Methods—
We conducted a retrospective study of a prospective database of 219 consecutive patients with spontaneous ICH admitted to the emergency department of a tertiary stroke center during a 3-year period. Prehospital SBP and ICH volume, ultra-early hematoma growth (ICH volume/onset-to-imaging time), and presence of the spot sign on admission were prospectively recorded. Primary outcome was ICH volume on admission. Secondary outcomes included ultra-early hematoma growth and frequency of the spot sign in patients scanned within 6 hours from symptom onset (hyperacute group).

Results—

Prehospital SBP was positively correlated with both SBP (
r
=0.552;
P
<0.001) and ICH volume (ρ=0.189;
P
=0.006) on admission. Patients with ICH volume above the median value presented higher prehospital SBP (172.3±35.0 versus 163.7±27.8 mm Hg;
P
=0.049). This association remained significant in adjusted multiple logistic regression analysis (odds ratio, 1.01 for a 1-U increase in SBP; 95% confidence interval, 1.01–1.02;
P
=0.018). In the hyperacute group (n=126), prehospital SBP was unrelated to ultra-early hematoma growth (ρ=0.115;
P
=0.203) nor the presence of the spot sign (172.2±27.6 versus 171.8±31.6 mm Hg;
P
=0.959).

Conclusions—
Prehospital SBP is correlated with SBP on admission and independently associated with ICH volume on admission. These findings support the rationale of testing whether prehospital initiation of BP-lowering attenuates ICH expansion.
Do Intracerebral Hemorrhage Nonexpanders Actually Expand Into the Ventricular Space?
Authors: Dowlatshahi Dar , Deshpande Anirudda , Aviv Richard I. , Rodriguez-Luna David , Molina Carlos A. , Blas Yolanda Silva , Dzialowski Imanuel , Kobayashi Adam , Boulanger Jean-Martin , Lum Cheemun , Gubitz Gordon J. , Padma Vasantha , Roy Jayanta , Kase Carlos S. , Bhatia Rohit , Hill Michael D. , Demchuk Andrew M. 
Published: November 2017

Background and Purpose—
The computed tomographic angiography spot sign as a predictor of hematoma expansion is limited by its modest sensitivity and positive predictive value. It is possible that hematoma expansion in spot-positive patients is missed because of decompression of intracerebral hemorrhage (ICH) into the ventricular space. We hypothesized that revising hematoma expansion definitions to include intraventricular hemorrhage (IVH) expansion will improve the predictive performance of the spot sign. Our objectives were to determine the proportion of ICH nonexpanders who actually have IVH expansion, determine the proportion of false-positive spot signs that have IVH expansion, and compare the known predictive performance of the spot sign to a revised definition incorporating IVH expansion.

Methods—
We analyzed patients from the multicenter PREDICT ICH spot sign study. We defined hematoma expansion as ≥6 mL or ≥33% ICH expansion or >2 mL IVH expansion and compared spot sign performance using this revised definition with the conventional 6 mL/33% definition using receiver operating curve analysis.

Results—
Of 311 patients, 213 did not meet the 6-mL/33% expansion definition (nonexpanders). Only 13 of 213 (6.1%) nonexpanders had ≥2 mL IVH expansion. Of the false-positive spot signs, 4 of 40 (10%) had >2 mL ventricular expansion. The area under the curve for spot sign to predict significant ICH expansion was 0.65 (95% confidence interval, 0.58–0.72), which was no different than when IVH expansion was added to the definition (area under the curve, 0.66; 95% confidence interval, 0.58–0.71).

Conclusions—
Although IVH expansion does indeed occur in a minority of ICH nonexpanders, its inclusion into a revised hematoma expansion definition does not alter the predictive performance of the spot sign.
Hippocrates in Two Syriac Alchemical Collections
Authors: Martelli Matteo 
Published: November 2017

In this article, I will explore the fortune of Hippocrates in the Syriac alchemical literature. I will investigate a so far unedited Syriac text (MS Cambridge University Library, Mm. 6.29, ff. 133r–134v) that presents Hippocrates as the founder of alchemy and medicine. This text is edited here for the first time, translated into English, and compared with other alchemical writings (both in Syriac and in Arabic) attributed to the ancient physician from Cos.
How Would the Twenty-First-Century Warming Influence Pacific Decadal Variability and Its Connection to North American Rainfall: Assessment Based on a Revised Procedure for the IPO/PDO
Authors: Xu Yangyang , Hu Aixue 
Published: November 2017

AbstractDecadal climate variability of sea surface temperature (SST) over the Pacific Ocean can be characterized by interdecadal Pacific oscillation (IPO) or Pacific decadal oscillation (PDO) based on empirical orthogonal function (EOF) analysis. Although the procedures to derive the IPO and PDO indices differ in their regional focuses and filtering methods to remove interannual variability, the IPO and PDO are highly correlated in time and are often used interchangeably. Studies have shown that the IPO and PDO conjointly (IPO/PDO for conciseness) play a vital role in modulating the pace of global warming. It is less clear, however, how externally forced global warming may, in turn, affect the IPO/PDO. One obstacle to revealing this effect is that the conventional definitions of the IPO/PDO fail to account for the spatial heterogeneity of the background warming trend, which causes the IPO/PDO to be conflated with the warming trend, especially for the twenty-first-century simulation when the forced change is likely to be more dominant. Using a large-ensemble simulation in the Community Earth System Model, version 1 (CESM1), it is shown here that a better practice of detrending prior to EOF analysis is to remove the local and nonlinear trend, defined as the ensemble-mean time series at each grid box (or simply as the quadratic fit of the local time series if such an ensemble is not available). The revised IPO/PDO index is purely indicative of internal decadal variability. In the twenty-first-century warmer climate, the IPO/PDO has a weaker amplitude in space, a higher frequency in time, and a muted impact on global and North American temperature and rainfall.