bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CATALOG OF 1.5273 μm DIFFUSE INTERSTELLAR BANDS BASED ON APOGEE HOT TELLURIC CALIBRATORS
Authors: Elyajouri M. , Monreal-Ibero A. , Remy Q. , Lallement R. 
Published: August 2016

ABSTRACT
High resolution stellar spectroscopic surveys provide massive amounts of diffuse interstellar bands (DIBs) measurements. Data can be used to study the distribution of the DIB carriers and those environmental conditions that favor their formation. In parallel, recent studies have also proved that DIBs extracted from stellar spectra constitute new tools for building the 3D structure of the Galactic interstellar medium (ISM). The amount of details on the structure depends directly on the quantity of available lines of sight. Therefore there is a need to construct databases of high-quality DIB measurements as large as possible. We aim at providing the community with a catalog of high-quality measurements of the 1.5273 μm DIB toward a large fraction of the Apache Point Observatory Galactic Evolution Experiment (APOGEE) hot stars observed to correct for the telluric absorption and not used for ISM studies so far. This catalog would complement the extensive database recently extracted from the APOGEE observations and used for 3D ISM mapping. We devised a method to fit the stellar continuum of the hot calibration stars and extracted the DIB from the normalized spectrum. Severe selection criteria based on the absorption characteristics are applied to the results. In particular limiting constraints on the DIB widths and Doppler shifts are deduced from the H i 21 cm measurements, following a new technique of decomposition of the emission spectra. From ∼16,000 available hot telluric spectra we have extracted ∼6700 DIB measurements and their associated uncertainties. The statistical properties of the extracted absorptions are examined and our selection criteria are shown to provide a robust dataset. The resulting catalog contains the DIB total equivalent widths, central wavelengths and widths. We briefly illustrate its potential use for the stellar and interstellar communities.
La longévité : passé, présent et futur
Authors: Vaupel James W. 
Published: August 2016

La longévité humaine a connu une hausse remarquable depuis 1840. En France, l'espérance de vie a doublé, passant de 40 ans en 1840 à 82 ans aujourd'hui. L'analyse de la nature de cet accroissement, y compris les progrès en termes de survie chez les personnes âgées, apporte un nouvel éclairage sur les transformations économiques, sociales et en matière de santé ayant eu lieu au cours des deux cents dernières années. Il se pourrait que l'avenir de la longévité soit tout aussi remarquable que son passé. Démographes, actuaires, gérontologues et autres experts de la mortalité sont largement en désaccord sur la question de savoir si l'espérance de vie se rapproche d'une limite inéluctable ou si, au contraire, elle continuera d'augmenter aussi rapidement que par le passé. Des méthodes de projection plus performantes sont nécessaires afin d'anticiper les évolutions économiques, sociales et de santé à venir. Classification JEL : J11, J14.
Le risque de longévité pour les fonds de pension
Authors: Latourrette Bruno 
Published: August 2016

Les fonds de pensions à prestations définies portent des risques importants de longévité dont le risque principal est celui dit de tendance lié à l'amélioration plus forte que prévue de l'espérance de vie des retraités. Ce dernier a été constamment sous-évalué depuis des décennies, ce qui se traduit par un sous-provisionnement actuel des engagements et des besoins importants de couverture de ce risque que le simple marché de l'assurance ne pourra pas gérer seul, d'où le besoin de trouver des solutions de marchés financiers qui, outre la capacité apportée, permettront une bien meilleure transparence sur les anticipations de mortalité. Classification JEL : G22, G23, J11, J14.
Le nouveau marché du risque de longévité
Authors: Blake David , Cairns Andrew , Coughlan Guy , Dowd Kevin , Macminn Richard 
Published: August 2016

L'impact considérable du risque de longévité sur le plan économique pour les entreprises, les gouvernements et les individus commence à être reconnu et quantifié. En raison de son ampleur et de sa prévalence, l'exposition au risque de longévité constitue en termes financiers la principale exposition à un risque lié à l'espérance de vie et représente une menace potentielle pour l'ensemble du système de retraite. Cet article revient sur la naissance et l'évolution du marché de la longévité, lié au transfert des risques de longévité et de mortalité. Nous constatons que l'émergence d'un marché et d'instruments liés à la longévité devrait agir comme un catalyseur pour faciliter le développement de marchés des rentes viagères à la fois dans les pays développés et en développement et protéger la viabilité à long terme des systèmes de retraite dans le monde entier. Classification JEL : G22, G23, J11, J14.
Le crowdfunding : modèle alternatif de financement ou généralisation du modèle de marché pour les start-up et les PME ?
Authors: Cieply Sylvie , Le Nadant Anne-Laure 
Published: August 2016

Le crowdfunding a été, à l'origine, présenté comme un modèle alternatif permettant de financer des projets risqués grâce à la foule. Les auteurs étudient l'évolution récente de la réglementation et le développement des multiples partenariats noués entre les plates-formes et les banques qui conduisent à la re-financiarisation du modèle initial. Leur analyse montre que le développement du crowdfunding ne conduit pas à un mouvement de désintermédiation mais, au contraire, qu'il généralise l'intermédiation de marché en proposant un outil de finance de marché adapté au non coté. Classification JEL : G21, G24, M13.
Les mécanismes économiques et financiers associés à la couverture dépendance : une analyse exploratoire sur données bancaires
Authors: Nayaradou Maximilien , Nouet Sébastien , Plisson Manuel 
Published: August 2016

La compréhension économique et financière des mécanismes liés aux besoins de couvertures relatifs aux produits d'assurance dépendance est devenue aujourd'hui une préoccupation pour le secteur de la bancassurance. L'inquiétude des Français sur l'avenir des systèmes de retraite et de l'Aide personnalisée d'autonomie (APA) renforce cette préoccupation. Les banques et distributeurs doivent ainsi cerner les attentes et motivations de leurs différents profils de clientèle afin de contribuer à développer davantage ce marché à fort potentiel. Cet article tente de répondre à cette préoccupation grâce à une étude qui se décompose en deux volets, un volet préliminaire et descriptif basé sur l'analyse exploratoire d'un portefeuille bancaire national, puis un volet économique et financier permettant de conjecturer les principaux mécanismes liés aux choix d'assurance et aux couvertures effectives associés à ces produits d'assurance Nos résultats seront ensuite comparés aux principaux résultats de la littérature sur le sujet. Classification JEL : G21, G22, I11, J14.
Ce que les liens transférentiels recèlent d’inventivité
Authors: Brun Danièle 
Published: August 2016

Est-il possible de parler d’inventivité ordinaire ? C’est-à-dire d’inventivité au quotidien ? S’agissant de celle des liens transférentiels – non pas quotidienne, mais articulée sur le quotidien –, l’inventivité me paraît chaque fois extra-ordinaire. On la voit le plus souvent surgir sur la toile de fond des activités des patients. Le récit qui en est fait en séance se double en général d’associations inédites. L’ensemble s’inscrit dans la dynamique transférentielle en en renouvelant l’accroche d’une façon que l’on peut qualifier d’inventive et/ou inédite.
Le pastout de Lacan… et celui de Lou
Authors: Pickmann Claude-Noële 
Published: August 2016

En inventant le pastout , Lacan n’a pas seulement éclairé le « continent noir » freudien, il a aussi rendu compte, logiquement, d’une structure trouée qui fonctionne à la suppléance phallique ainsi que Freud l’avait découvert sans trouver les outils conceptuels pour le démontrer. Ainsi le pastout concerne les hommes tout autant que les femmes même si elles semblent y avoir un rapport plus immédiat, comme l’a montré exemplairement Lou Andréa Salomé. Qu’un sujet puisse se situer par rapport à ce trou, qu’il invente un savoir-faire avec ce qu’il recrache, ou avec le trou lui-même, au lieu de se laisser engloutir par la jouissance qu’il recèle, ce peut être la visée d’une analyse qui n’aurait pas que la norme œdipienne comme horizon.
L’inventivité de Ferenczi
Authors: Lauru Didier 
Published: August 2016

Sàndor Ferenczi, un analyste et ami de Freud, analysé par lui, a fait preuve tout au long de sa pratique et son œuvre d’une originalité et d’une inventivité sans égales. Il a écrit une œuvre particulière, inventant des concepts, insistant pour que les analystes soient analysés puis qu’ils fassent des contrôles dans leur formation. Mais surtout il a, au fil de textes majeurs ou de petits écrit très cliniques, introduisant des concepts majeurs comme l’introjection, amené une autre façon de concevoir l’analyse. Son inventivité s’est déployée au travers de techniques : élastique, active, mutuelle. En particulier, il a tenté de s’attaquer aux résistances de l’analysant par d’autres angles. Une œuvre riche à (re)découvrir.
Managing PBL difficulties in an industrial engineering and management program
Authors: Alves Anabela , Sousa Rui , Moreira Francisco , Carvalho M. Alice , Cardoso Elisabete , Pimenta Pedro , Malheiro Teresa , Brito Irene , Fernandes Sandra , Mesquita Diana 
Published: August 2016

Purpose: Project-Based Learning (PBL) is considered to be an active learning methodology which can be used to develop both technical and transversal competences in engineering programs. This methodology demands a great deal of work effort from the students and also from the teachers and it requires a meticulous plan and a well-managed project as well. These activities go far beyond the normal activities in traditional lectures, enabling to outpace the difficulties that spur along the way that may be both complex and demotivating. This methodology has been implemented in the Integrated Master Degree on Industrial Engineering and Management (IEM), at one public university in Portugal, since the 2004/2005 academic year. The aim of this paper is to identify and discuss the main difficulties of the implementation of PBL, mainly from the teachers’ perspectives. Additionally, some effective strategies will be recommended to overcome such difficulties.Design/methodology/approach: The perceptions of the teachers were collected through a survey based on six main themes. The participants in the study include eight teachers from the five courses of the first semester of the first year of the IEM program involved in the 2012/2013 and 2013/2014 editions.Findings: Integration of courses in the project; student assessment; growing number of students in each team and the need of physical spaces for them; and compartmentalized knowledge has emerged as the main difficulties. To overcome these difficulties some key strategies were recommended.Originality/value: A new perspective based on course teachers' views and experiences will deepen the understanding of the problems and provide inputs for the development of strategies that may improve the effectiveness of PBL and introduce changes for its successful implementation. These strategies are intended to be transferable to other contexts, as most of the problems and constraints are common to other active learning approaches.
Analytical Eco-Scale for Assessing the Greenness of a Developed RP-HPLC Method Used for Simultaneous Analysis of Combined Antihypertensive Medications
Authors: Mohamed Heba M , Lamie Nesrine T 
Published: August 2016

Abstract
In the past few decades the analytical community has been focused on eliminating or reducing the usage of hazardous chemicals and solvents, in different analytical methodologies, that have been ascertained to be extremely dangerous to human health and environment. In this context, environmentally friendly, green, or clean practices have been implemented in different research areas. This study presents a greener alternative of conventional RP-HPLC methods for the simultaneous determination and quantitative analysis of a pharmaceutical ternary mixture composed of telmisartan, hydrochlorothiazide, and amlodipine besylate, using an ecofriendly mobile phase and short run time with the least amount of waste production. This solvent-replacement approach was feasible without compromising method performance criteria, such as separation efficiency, peak symmetry, and chromatographic retention. The greenness profile of the proposed method was assessed and compared with reported conventional methods using the analytical Eco-Scale as an assessment tool. The proposed method was found to be greener in terms of usage of hazardous chemicals and solvents, energy consumption, and production of waste. The proposed method can be safely used for the routine analysis of the studied pharmaceutical ternary mixture with a minimal detrimental impact on human health and the environment.
Is Brachial Artery Blood Flow Measured by Sonography During Early Postoperative Periods Predictive of Arteriovenous Fistula Failure in Hemodialysis Patients?
Authors: Zhu Yu-li , Ding Hong , Fan Pei-li , Gu Qi-lan , Teng Jie , Wang Wen-ping 
Published: August 2016

ObjectivesThe aim of our study was to determine a brachial artery blood flow level measured by sonography during early postoperative periods that is predictive of arteriovenous fistula failure in hemodialysis patients.MethodsDoppler sonography was used to estimate the blood flow in the brachial artery of 103 patients at 1 and 14 days after arteriovenous fistula creation. The performance of brachial artery blood flow during early postoperative periods for predicting fistula failure was evaluated, and optimal cutoff values were determined.ResultsDuring a 6‐month follow‐up, 85 fistulas were classified as mature, and 18 were classified as failures. The reproducibility of blood flow measurements in the brachial artery was good (intraclass correlation coefficient, 0.912). The blood flow in the failure group was significantly lower than that in the mature group at both 1 and 14 days after fistula creation (P < .05). During the first 2 postoperative weeks, the blood flow increased by 40.7% in the failure group versus 78.3% in the mature group. The areas under the receiver operating characteristic curves of brachial artery blood flow for predicting failure were 0.77 (95% confidence interval, 0.66–0.87; optimal cutoff value, 310 mL/min)at 1 day and 0.91 (95% confidence interval, 0.83–0.99; 413 mL/min) at 14 days after fistula creation.ConclusionsBrachial artery blood flow measured by sonography during early postoperative periods may be predictive of forearm fistula failure. Blood flow of less than 310 mL/min at 1 day and 413 mL/min at 14 days after fistula creation may indicate a risk of failure to mature.
Patient Self-Guided Interventions to Reduce Sedative Use and Improve Sleep
Authors: Gardner David M. , Turner Justin P. , Magalhaes Sandra , Rajda Malgorzata , Murphy Andrea L. 
Published: September 2024

ImportanceDirect-to-patient interventions enabling transitions from long-term benzodiazepine receptor agonist (BZRA) use to cognitive behavioral therapy for insomnia (CBTI) by older adults has the potential to reduce BZRA use and related harms while improving sleep outcomes without requiring prearranged clinician involvement.ObjectiveTo compare 2 direct-to-patient behavior change interventions with treatment as usual (TAU) on BZRA use, sleep, and other health outcomes, and uptake of CBTI techniques.Design, Setting, and ParticipantsThe Your Answers When Needing Sleep in New Brunswick (YAWNS NB) study was a 3-arm, pragmatic, open-label, minimum-contact, randomized clinical trial. The study began November 2020 and ended June 2022. Participants were randomly allocated to 1 of 3 groups, including 2 different mailed behavior change interventions or no intervention (TAU). Participants were from communities across the province of New Brunswick, Canada, and included adults 65 years and older living independently with long-term use of BZRAs and current or past insomnia.InterventionsThe Sleepwell package (YAWNS-1) consisted of a cover letter and 2 booklets (“How to Stop Sleeping Pills” and “How to Get Your Sleep Back”). The other package (YAWNS-2) included updated versions of the 2 booklets (“You May Be at Risk” and “How to Get a Good Night’s Sleep Without Medication”) used in the Eliminating Medications Through Patient Ownership of End Results (EMPOWER) study.Main Outcomes and MeasuresBZRA use at 6 months was the primary measure. Secondary measures included CBTI use, sleep, insomnia, daytime sleepiness, safety, anxiety, frailty, and quality of life.ResultsA total of 1295 individuals expressed interest in the study, and 565 (43.6%) completed a baseline assessment. Participants had a mean (SD) age of 72.1 (5.7) years, a mean (SD) BZRA use duration of 11.4 (9.1) years, and 362 (64.1%) were female. Discontinuations and dose reductions of 25% or greater were highest with YAWNS-1 (50 of 191 [26.2%]; 39 of 191 [20.4%]; total, 46.6%) compared with YAWNS-2 (38 of 187 [20.3%]; 27 of 187 [14.4%]; total, 34.8%, P = .02) and TAU (14 of 187 [7.5%]; 24 of 187 [12.8%]; total, 20.3%, P &amp;lt; .001). YAWNS-1 also demonstrated better uptake of CBTI techniques and sleep outcomes compared with YAWNS-2 (new CBTI techniques: 3.1 vs 2.4; P =.03; sleep efficiency change: 4.1% vs −1.7%; P =.001) and reduced insomnia severity and daytime sleepiness compared with TAU (insomnia severity index change: −2.0 vs 0.3; P &amp;lt;.001; Epworth Sleepiness Scale change: −0.8 vs 0.3; P =.001).Conclusions and RelevanceResults of the YAWNS NB randomized clinical trial show that, as a simple, scalable, direct-to-patient intervention, YAWNS-1 substantially reduced BZRA use and improved sleep outcomes. It could be implemented to transform insomnia care for older adults at the population level.Trial RegistrationClinicalTrials.gov Identifier: NCT04406103
α‐Synuclein species in plasma neuron‐derived extracellular vesicles as biomarkers for iRBD
Authors: Wang Xuemei , Zheng Yuanchu , Cai Huihui , Kou Wenyi , Yang Chen , Li Siming , Zhu Bingxu , Wu Jiayi , Zhang Ning , Feng Tao , Li Xiaohong , Xiao Fulong , Yu Zhenwei 
Published: September 2024

AbstractObjectiveIsolated REM sleep behavior disorder (iRBD) is considered as the strongest predictor of Parkinson's disease (PD). Reliable and accurate biomarkers for iRBD detection and the prediction of phenoconversion are in urgent need. This study aimed to investigate whether α‐Synuclein (α‐Syn) species in plasma neuron‐derived extracellular vesicles (NDEVs) could differentiate between iRBD patients and healthy controls (HCs).MethodsNanoscale flow cytometry was used to detect α‐Syn‐containing NDEVs in plasma.ResultsA total of 54 iRBD patients and 53 HCs were recruited. The concentrations of total α‐Syn, α‐Syn aggregates, and phosphorylated α‐Syn at Ser129 (pS129)‐containing NDEVs in plasma of iRBD individuals were significantly higher than those in HCs (p < 0.0001 for all). In distinguishing between iRBD and HCs, the area under the receiver operating characteristic (ROC) curve (AUC) for an integrative model incorporating the levels of α‐Syn, pS129, and α‐Syn aggregate‐containing NDEVs in plasma was 0.965. This model achieved a sensitivity of 94.3% and a specificity of 88.9%. In iRBD group, the concentrations of α‐Syn aggregate‐containing NDEVs exhibited a negative correlation with Sniffin’ Sticks olfactory scores (r = −0.351, p = 0.039). Smokers with iRBD exhibited lower levels of α‐Syn aggregates and pS129‐containing NDEVs in plasma compared to nonsmokers (pα‐Syn aggregates = 0.014; ppS129 = 0.003).InterpretationThe current study demonstrated that the levels of total α‐Syn, α‐Syn aggregates, and pS129‐containing NDEVs in the plasma of individuals with iRBD were significantly higher compared to HCs. The levels of α‐Syn species‐containing NDEVs in plasma may serve as biomarkers for iRBD.
“Internal Trouble and Outside Aggression” Strategy: Energy Deprivation Synergized With cGAS‐STING Pathway Activation for Stimuli‐Responsive Photodynamic‐Metal‐Metabolic Immunotherapy
Authors: Qian Yanrong , Xie Yulin , Zhu Guoqing , Wang Man , Wang Junrong , Sun Qianqian , Lin Jun , Li Chunxia 
Published: September 2024

AbstractThe aberrant metabolic activities of tumor cells not only facilitate tumor proliferation but also impair immune cell function and cause an immunosuppressive tumor microenvironment (TME). Thus, reshaping the metabolic TME while activating innate immunity is highly desirable but challenging. Herein, a multifunctional immunomodulator is engineered for near‐infrared light (NIR)‐triggered photodynamic‐metal‐metabolic immunotherapy via the “internal trouble and outside aggression” strategy. Specifically, an endogenous and exogenous stimuli‐responsive nanoagent is prepared consisting of photosensitizer chlorin e6 (Ce6) modified dense silica‐coated rare earth‐doped nanoparticles (ReNPs@SiO2(Ce6)), with in situ grown ZIF‐8 on the surface for loading glucose transporter‐1 (GLUT‐1) inhibitor Fasentin and glutaminase‐1 inhibitor bis‐2‐(5‐phenylacetamido‐1,3,4‐thiadiazol‐2‐yl)ethyl sulfide (BPTES). The as‐obtained final product is denoted as ReSZ(FB). ReSZ(FB) induces‐ mitochondrial damage and releases mitochondrial DNA (mtDNA) via NIR‐mediated PDT. Subsequently, Zn2+ from ZIF‐8 collaborates with mtDNA to activate the cGAS‐STING pathway, initiating a robust tumor‐specific immune response. Concurrently, Fasentin and BPTES triggeres energy deprivation by blocking glucose uptake and inhibiting glutamine decomposition, thereby reprogramming the metabolic TME, and alleviating immunosuppression. Tumor cells are damaged and trapped into “internal trouble” by combining PDT and energy deprivation, while the sharply enhanced immune cell lethality exposes cancer cells to “outside aggression”. Overall, this photodynamic‐metal‐metabolic immunotherapy provides a promising paradigm for cancer therapy.
Multi‐Chambered Core/Shell Supraparticles for Real‐Time, Full‐Time Diagnosis and Treatment Integration of Tumors
Authors: Kong Degang , Zheng Xiaotong , Ding Kai , Zhong Run , Zhang Zhao , Wang Qingyi , Dong Chunxiu , Zheng Zhiwen , Li Xiaohong , Weng Jie , Zhou Shaobing 
Published: September 2024

AbstractTo a certain extent, theranostic nanoplatforms promote tumor treatment efficiency. However, timely monitoring of the critical stages and signal sustainability of the entire process is challenging. In this study, multi‐chambered core/shell magnetic nanoparticles (MC‐MNPs) as drug and imaging agent multi‐loaded nanocarriers with a synergistic release function are reported. Supraparticles with stable chambers are formed by the supercooling self‐assembly of several core/shell magnetic nanoparticles composed of amphiphilic copolymers as the core and hydrophilic magnetic iron oxide nanoparticles as the shell. Desalinized doxorubicin and coumarin 6 are stored in different cavities of nanocarriers, and chitosan is used as an outer encapsulation layer. Based on their construction properties, MC‐MNPs can exhibit gradient‐degraded and steady‐released controllability in the tumor environment. Furthermore, real‐time accumulation situations and full‐time diagnostic signals of nanocarriers are thoroughly demonstrated using fluorescence imaging and T2‐weighted magnetic resonance imaging before and after magnetic hyperthermia in targeted tumors under an alternating magnetic field. Thus, MC‐MNPs as theranostic nanocarriers exhibit great potential for the timely monitoring and full‐time guidance of tumor treatment.