bluuebunny/crossref_metadata_2025_split huggingface dataset:
Soft tissue myxofibrosarcoma: A clinico‐pathological analysis of a series of 75 patients with emphasis on the epithelioid variant
Authors: Scoccianti Guido , Ranucci Valentina , Frenos Filippo , Greto Daniela , Beltrami Giovanni , Capanna Rodolfo , Franchi Alessandro 
Published: April 2016

Background and ObjectivesThe clinical course of soft tissue myxofibrosarcoma is characterized by a high incidence of recurrences and there is no agreement on how to identify patients at major risk. An epithelioid histological variant has been described, with a possible worse prognosis. We reviewed our series to identify prognostic factors and assess clinical significance of the epithelioid variant.MethodsWe examined the clinico‐pathological features of a series of 75 patients affected by soft tissue myxofibrosarcoma at a mean follow‐up of 63 months (range 17–132).ResultsDisease specific survival and local recurrence free survival were, respectively, 84.8% and 76.8% at 5 years. Seven patients (8.6%) presented with the epithelioid variant with a survival of 62.5%. High grade and epithelioid morphology were negative prognostic factors for patient survival, high grade, and inadequate surgical margins for local recurrence. Radiotherapy had a local protective effect in high grade tumors.ConclusionsOur experience confirms the difficulties in obtaining wide margins in myxofibrosarcoma and the high rate of recurrence. Local recurrences did not significantly affect survival and a limb‐sparing approach can be chosen also in recurrences. Patients affected by the epithelioid variant showed a worse prognosis. Chemotherapy should be considered as adjuvant treatment in this subtype. J. Surg. Oncol. 2016;114:50–55. © 2016 Wiley Periodicals, Inc.
Long‐term outcomes in treatment of retroperitoneal sarcomas: A 15 year single‐institution evaluation of prognostic features
Authors: Abdelfatah Eihab , Guzzetta Angela A. , Nagarajan Neeraja , Wolfgang Christopher L. , Pawlik Timothy M. , Choti Michael A. , Schulick Richard , Montgomery Elizabeth A. , Meyer Christian , Thornton Katherine , Herman Joseph , Terezakis Stephanie , Frassica Deborah , Ahuja Nita 
Published: April 2016

BackgroundRetroperitoneal sarcomas are connective tissue tumors arising in the retroperitoneum. Surgical resection is the mainstay of treatment. Debate has arisen over extent of resection, changes in histological classification/grading, and interest in incorporating radiotherapy. Therefore, we reviewed our institution's experience to evaluate prognostic factors.MethodsRetrospective chart review of all primary RPS patients at Johns Hopkins Hospital from 1994 to 2010. Histologic diagnosis and grading were re‐evaluated with current criteria. Prognostic factors for survival, and recurrence were assessed.ResultsOne hundred thirty‐one primary RPS patients met inclusion criteria. Median survival for patients who undergo en‐bloc resection to negative margins (R0/R1) is 81.7 months. Surgical margins and grade were the most important factors for survival along with age, gender, presence of metastases and resection of ≥5 organs. Five‐year survival for R0/R1 resection was 60%, similar to compartmental resection. Radiotherapy significantly decreased local recurrence (P = 0.026) on multivariate analysis. Grade in leiomyosarcomas and dedifferentiation in liposarcomas dictated patterns of local versus distal recurrence.ConclusionsEn bloc surgical resection to R0/R1 margins remains the cornerstone of therapy and provides comparable outcomes to compartmental resections. Grade remains important for prognosis, and histology dictates recurrence patterns. Radiotherapy appears promising for local control and warrants further investigation. J. Surg. Oncol. 2016;114:56–64. © 2016 Wiley Periodicals, Inc.
Circumferential resection margins and perineal complications after neoadjuvant long‐course chemoradiotherapy followed by extralevator abdominoperineal excision of the rectum: Five years of activity at a single institution
Authors: Gravante Gianpiero , Miah Anur , Mann Christopher D. , Stephenson James Andrews , Gani Mohamed Akil Dilawar , Sharpe David , Norwood Michael , Boyle Kirsten , Miller Andrew , Hemingway David 
Published: April 2016

BackgroundProne extralevator abdominoperineal excision of the rectum (ELAPE) has been introduced to improve the circumferential resection margins (CRM) compared with traditional APER.ObjectiveWe present short‐term results achieved with prone ELAPE preceded by neoadjuvant chemoradiotherapy during the last 5 years of activity.DesignA retrospective review was conducted.Settings and PatientsProne ELAPE operations performed between September 2010 and August 2014 at Leicester Royal Infirmary preceded by neoadjuvant chemoradiotherapy.Interventions and Main Outcome MeasuresData regarding demographics, staging, neoadjuvant therapies, intraoperative perforations, and perineal complications were collected.ResultsSeventy‐two patients were included. Pretreatment radiological T4 were 25.0%, histological T4 2.8%. Intraoperative perforations occurred in 2.8%, CRM was involved in 11.1%. Perineal complications consisted of superficial wound infections (20.8%), full thickness dehiscences (16.7%), hematomas (9.7%), pelvic collections (6.9%), and perineal hernias (5.6%).ConclusionsIn our experience, prone ELAPE preceded by long‐course chemoradiotherapy has been successfully used in the last 5 years to resect low rectal tumors. Perineal wound complications rates are similar to those presented in series using direct perineal closures. J. Surg. Oncol. 2016;114:86–90. © 2016 Wiley Periodicals, Inc.
Focus on audiologic impairment in eosinophilic granulomatosis with polyangiitis
Authors: Seccia Veronica , Fortunato Susanna , Cristofani‐Mencacci Lodovica , Dallan Iacopo , Casani Augusto P. , Latorre Manuela , Paggiaro Pierluigi , Bartoli Maria Laura , Sellari‐Franceschini Stefano , Baldini Chiara 
Published: April 2016

Objectives/HypothesisTo evaluate the clinical features of audiologic impairment and its relationship with the nasal, vestibular, and rheumatologic profile in a cohort of patients with eosinophilic granulomatosis with polyangiitis (EGPA), formerly named Churg‐Strauss syndrome.Study DesignProspective cross‐sectional study.MethodsThirty‐nine patients with EGPA, considered controlled according to the Birmingham Vasculitis Activity Score and the Vasculitis Damage Index, underwent a complete audiologic evalutaion with otomicroscopy, impedance audiometry, speech audiometry, and auditory brainstem responses; rhinologic evaluation was made by means of fiberoptic endoscopy and nasal cytology; the clinical evaluation was completed with analysis of the facial function and, in patients with referred vertigo, with videonystagmography (VNG). Data were compared to the rheumatologic profile (eosinophil count, antineutrophil cytoplasmic antibodies status).ResultsThirty‐four of 39 patients fulfilled the inclusion criteria. Of those, 18 (52, 8%) were affected by variable degrees of hearing loss (sensorineural hearing loss [SNHL]) in four cases (11, 8%), mixed sensorineural and conductive hearing loss in two (5, 9%), presbycusis in six (17, 6%), and otitis media with effusion (OME) in six (17, 6%). Vestibular impairment was represented by benign paroxysmal positional vertigo and unspecific dizziness in three (8, 8%) and four cases (11, 8%), respectively, all with normal VNG. Ear involvement was statistically related to the EGPA vasculitic pattern and independent from the nasal impairment, cytology, and duration of nasal symptoms. No facial palsy was registered.ConclusionIn our experience, the largest in the existing literature, the otological involvement in EGPA is common and may occur variably as SNHL or OME. Otological involvement occurs early in the course of the disease process, but is nonspecific in making the diagnosis of EGPA. Its recognition is therefore fundamental.Level of Evidence4. Laryngoscope, 126:2792–2797, 2016
Impact of cochlear implantation on quality of life and mental comorbidity in patients aged 80 years
Authors: Knopke Steffen , Gräbel Stefan , Förster‐Ruhrmann Ulrike , Mazurek Birgit , Szczepek Agnieszka J. , Olze Heidi 
Published: April 2016

Objectives/HypothesisThe objective of this study was to evaluate the outcome of cochlear implantation in elderly patients (80 or older) with progressive bilateral deafening. The measured outcomes included the quality of life, speech understanding, tinnitus distress, stress level, anxiety, and depressiveness.Study DesignProspective cohort study.MethodsSeventeen 80+ years (mean 82.9 ± 2.7 years) patients with progressive, postlingual, bilateral deafness were unilaterally implanted with multichannel cochlear implants. Data about their health‐related quality of life (Nijmegen Cochlear Implantation Questionnaire) and their comorbidities were collected using specific validated questionnaires (tinnitus questionnaire, General Anxiety Disorder‐7, Depression Scale, Perceived Stress Questionnaire). The speech understanding was assessed with the Freiburg Monosyllabic Test, whereas the subjective hearing was evaluated with the Oldenburg Inventory.ResultsAfter the surgery, not only the subjective hearing but also health‐related quality of life, speech understanding, and tinnitus distress of the implanted patients improved significantly. The perceived stress, general anxiety, and depressiveness were low or normal prior and after surgery.ConclusionThis study demonstrates a significant improvement in the quality of life and speech understanding in a group of elderly patients who underwent cochlear implantation. An additional positive indicator of a promising hearing rehabilitation was a significant improvement of the tinnitus distress. Perceived stress level, general anxiety, and the depressiveness of implanted patients were low and remained unaffected.Level of Evidence4. Laryngoscope, 126:2811–2816, 2016
The effect of anchors on reliability of endoscopic tremor ratings
Authors: Lowell Soren Y. , Kelley Richard T. , Busekroos Lauren , Voleti Ramani , Hosbach‐Cannon Carly J. , Colton Raymond H. , Mihaila Dragos 
Published: April 2016

Objectives/HypothesisThe purpose of this study was to determine the effects of anchors and training on intrarater and inter‐rater reliability for visual‐perceptual, endoscopic tremor ratings.Study DesignProspective cohort study.MethodsNasoendoscopy recordings of 10 participants with a diagnosis of essential voice tremor were evaluated by five voice specialists using the Vocal Tremor Scoring System. Ratings were performed before, immediately after, and 4 weeks after implementation of a training program with anchor stimuli. Immediate and long‐term post‐training ratings were performed with simultaneous use of anchor samples for each rating.ResultsIntrarater reliability showed significant improvement from pretraining to immediate and long‐term post‐training. Mean correlation coefficients (Spearman's rho) increased from 0.71 at pretraining to 0.84 and 0.90 at immediate and long‐term post‐training, respectively. Inter‐rater reliability was not affected by training with anchors, with mean correlation coefficients ranging from 0.62 at pretraining to 0.58 and 0.64 at immediate and long‐term post‐training, respectively.ConclusionsConsistent, reproducible ratings are critical for the interpretation and comparison of endoscopic tremor data. Reliability findings from this study indicate that the use of anchor samples as referents for making ordinal judgments about the severity of tremor in oropharyngeal and laryngeal regions was helpful for improving internal standards and consistency but less useful for calibrating across different raters.Level of Evidence4 Laryngoscope, 2016 127:411–416, 2017
Effect of a 308‐nm excimer laser on atopic dermatitis‐like skin lesions in NC/Nga mice
Authors: Oh Chang Taek , Kwon Tae‐Rin , Seok Joon , Choi Eun Ja , Kim Soon Re , Jang Yu‐Jin , Mun Seog Kyun , Kim Chan Woong , Lee Sungeun , Lee Jongmin , Kim Myeung Nam , Choi Sun Young , Kim Beom Joon 
Published: April 2016

Background and ObjectiveAtopic dermatitis (AD) is a common inflammatory skin disease that can affect all age groups. It has a relapsing course, which dramatically affects the quality of life of patients. A 308‐nm excimer laser has been reported to be a safe and effective treatment for inflammatory skin diseases, although the range of potential application has not been fully explored. The purpose of this study was to evaluate the therapeutic effects of a 308‐nm laser on AD‐like skin lesions in NC/Nga mice.Study Design/Materials and MethodsDermatophagoides farinae‐exposed NC/Nga mice with a clinical score of 12 were treated with either a 308‐nm excimer laser or narrowband‐UVB (NB‐UVB). The effects of the 308‐nm excimer laser were evaluated by dermatitis scores, skin histology, skin barrier function, and immunological parameters, including IgE and Th2‐mediated cytokines.ResultsThe 308‐nm excimer laser significantly reduced the severity of skin lesions and decreased the total serum levels of IgE and Th2‐mediated cytokines. The excimer laser also significantly reduced the inflammatory cellular infiltrate into AD‐induced skin lesions. Moreover, treatment with the 308‐nm excimer laser led to recovery of skin barrier function in AD‐induced skin lesions.ConclusionThe 308‐nm excimer laser can be considered a valid and safe therapeutic option for the treatment of localized AD. Lasers Surg. Med. 48:629–637, 2016. © 2016 Wiley Periodicals, Inc.
The Impact of Continuous Oxygen Flux in a Thin Film Photopolymerization Reaction with Peroxy‐Mediated Regeneration of Initiator
Authors: Wong Jisam , Sikes Hadley D. 
Published: April 2016

Eosin, a photosensitizer dye that can exist in multiple oxidation states, has been shown to initiate visible‐light photopolymerizations of acrylates in open air when used in combination with tertiary amines. The exact mechanism behind this reactivity with micromolar concentrations of eosin in aqueous monomer solutions initially containing millimolar concentrations of oxygen has not been conclusively established, although pathways for regeneration of eosin in the presence of oxygen certainly play a role. In this work, a reaction–diffusion model incorporating a peroxy‐mediated eosin‐regeneration mechanism is built to explore the effects of oxygen diffusing into the system as the light‐activated reaction proceeds. An oxygen concentration‐dependent flux boundary condition is used to model the continuous replenishment of oxygen at the surface open to air as it is consumed by reaction. The model predicts the formation of a free radical concentration front that initially forms closer to the open surface and gradually moves toward the closed surface, with polymer film thickness increasing and the time required for polymerization to begin decreasing as the initial eosin concentration is increased. These results suggest that oxygen's dual role as both a free radical inhibitor and a precursor of the oxidizing species required for regeneration of eosin brings about interesting spatial variations when the reaction is carried out in a thin film geometry that is exposed to open air. In this case, an assumption of a well‐mixed system is not appropriate and the kinetics of the reaction and conversion as a function of position are likely to depend on the geometry of the system.
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Porosity control in high internal phase emulsion templated polyelectrolytes via ionic crosslinking
Authors: Streifel Benjamin C. , Parker Joseph F. , Giles Spencer L. , Williams Sierra J. , Duncan Jesse H. , Wynne James H. 
Published: April 2016

ABSTRACTA series of novel macroporous materials based on poly(N‐isopropylacrylamide)‐b‐sodium polyacrylate is synthesized via aqueous reversible addition‐fragmentation chain transfer polymerization in an oil‐in‐water high internal phase emulsion (HIPE) utilizing both covalent and ionic crosslinkers (PEG diacrylate and calcium diacrylate, respectively). Porosity is directly related to the calcium diacrylate content of the polyHIPE. Depth profiling XPS of pressed samples reveal the segregation of less polar substituents (PNIPAM, PEGDA) to the interface, whereas ionic components are located deeper within the continuous aqueous phase, primarily driven by ionic strength. This segregation of components stabilizes the internal‐continuous phase interface and results in decreased void diameter. Calcium diacrylate also forms ionic crosslinks in the polyHIPE material, resulting in increased interconnecting pore diameter due to volume contraction upon polymerization. Evidence of volume contraction is provided by the stress induced on PEG at the o/w interface by internally located calcium polyacrylate crosslinks, resulting in a decrease in XRD peak intensity. It is therefore proposed that calcium diacrylate is capable of modifying polyHIPE morphology via two separate mechanisms. Published 2016. Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 2486–2492
Comparative analysis of shape memory‐based self‐healing coatings
Authors: Birjandi Nejad Hossein , Garrison Katie L. , Mather Patrick T. 
Published: April 2016

ABSTRACTSelf‐healing materials exhibit the ability to repair and to recover their functionality upon damage. Here, we report on an investigation into preparation and characterization of shape memory assisted self‐healing coatings. We built on past work in which poly(ε‐caprolactone) electrospun fibers were infiltrated with a shape memory epoxy matrix and delve into fabricating and characterizing a coating with the same materials, but employing a blending approach, polymerization induced phase separation. After applying controlled damage, the ability of both coatings to self‐heal upon heating was investigated. In both methods, coatings showed excellent thermally induced crack closure and protection against corrosion, with the blend approach being more suitable for large‐scale applications given its process simplicity. Two different approaches to the preparation of shape memory‐based self‐healing coatings were compared for their ability to heal structurally and functionally by heating. These two approaches, electrospinning versus polymerization‐induced phase separation were found to feature comparable and quite complete healing, with the latter system offering the advantage of facile processing. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 1415–1426
The effect of molecular structure on the secondary transitions and their influence on the decoloration kinetics of photochromic dyes in co‐polycarbonates
Authors: Micciche Fabrizio , Ramakrishnan Vaidyanath , Hoeks Theodorus L. 
Published: April 2016

ABSTRACTPhotochromic dyes have restricted use in rigid polycarbonates because of slow coloration and decoloration kinetics. In this study, it is shown that the decoloration kinetics of two photochromic dyes can be controlled by tuning the chain stiffness and free volume of the host matrix. The introduction of flexible moieties in rigid BPA‐based polycarbonate chain accelerates the decoloration of these dyes whereas a rigid co‐monomer delays the decoloration kinetics. Although Tg might be used as a parameter to improve photochromism in polymer matrices, dynamic mechanical analysis demonstrates that the decoloration kinetics of the dyes in host polymer matrices having similar Tg depends primarily on the secondary relaxations and, thus, on the polymer architecture. The effect of the co‐monomer type on the characteristic ratio is also discussed underlining the potential relationship between the free volume and chain stiffness. These results open the possibility to develop transparent or semitransparent photochromic materials based on tailor‐made co‐polycarbonates. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 1593–1601
Photosensitive MIS structures with ultrathin dielectric based on CdXHg1‐XTe (x ∼ 0.4)
Authors: Kesler Valeriy G. , Guzev Alexander A. , Dvoretskiy Sergey A. , Zakirov Evgeniy R. , Kovchavtsev Anatoliy P. , Panova Zoya V. , Yakushev Maxim V. 
Published: April 2016

AbstractThe work is aimed to studying a possibility of CdHgTe surface passivation and stabilization by tunnel‐thin (∼ 2 nm) native oxide formed by glow discharge plasma oxidation. Kinetics of MCT plasma treatment in two regimes has been obtained. Investigation of the stabilization effect during vacuum annealing and platinum deposition has been performed. It has been established that presence of a native oxide layer on MCT surface results in elimination of mercury out diffusion during the processes. MIS structures with platinum contacts and thin native oxide have been made. They have rectifying behaviour in contrast with structures without the native oxide layer. The barrier height and the detectivity have been determined from the capacitance‐voltage and current‐voltage dependences. The detectivity value of 4×1011cm.Hz1/2W‐1 (at 78 K) determined by dark current shot noise has been reached. (© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Software and applications of spatial data mining
Authors: Li Deren , Wang Shuliang , Yuan Hanning , Li Deyi 
Published: April 2016

Most big data are spatially referenced, and spatial data mining (SDM) is the key to the value of big data. In this paper, SDM are overviewed in the aspects of software and application. First, spatial data are summarized on their rapid growth, distinct characteristics, and implicit values. Second, the principles of SDM are briefed with the descriptive definition, fundamental attributes, discovery mechanism, and usable methods. Third, SDM software is presented in the context of software components, developing methodology, typical software for geographical information system (GIS) data and remote sensing (RS) images, and software trend. Fourth, SDM applications are outlined on GIS data, RS image, and spatiotemporal video data. The final is the concluding remarks and perspectives. WIREs Data Mining Knowl Discov 2016, 6:84–114. doi: 10.1002/widm.1180This article is categorized under:

Algorithmic Development > Spatial and Temporal Data Mining
Application Areas > Industry Specific Applications
Constraint logic programming with a relational machine
Authors: Gallego Arias Emilio Jesús , Lipton James , Mariño Julio 
Published: April 2016

Abstract
We present a declarative framework for the compilation of constraint logic programs into variable-free relational theories which are then executed by rewriting. This translation provides an algebraic formulation of the abstract syntax of logic programs. Logic variables, unification, and renaming apart are completely elided in favor of manipulation of variable-free relation expressions. In this setting, term rewriting not only provides an operational semantics for logic programs, but also a simple framework for reasoning about program execution. We prove the translation sound, and the rewriting system complete with respect to traditional SLD semantics.