bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meal and snack frequency in relation to diet quality in US children and adolescents: the National Health and Nutrition Examination Survey 2003–2012
Authors: Murakami Kentaro , Livingstone M Barbara E 
Published: February 2016

AbstractObjectiveTo examine the associations of meal frequency (MF) and snack frequency (SF) with diet quality.DesignDietary intake was assessed using two 24 h dietary recalls. All eating occasions providing ≥210 kJ of energy were divided into meals or snacks on the basis of contribution to energy intake (≥15 % or <15 %), self-report and time (06.00–09.00, 12.00–14.00 and 17.00–20.00 hours, or others). Diet quality was assessed using the Healthy Eating Index (HEI)-2010.SettingNationally representative sample of the US population.SubjectsChildren aged 6–11 years (n 4269) and adolescents aged 12–19 years (n 6193) in the National Health and Nutrition Examination Survey 2003–2012.ResultsIrrespective of the definition of meals, higher MF was associated with higher HEI-2010 in both children and adolescents. One additional meal per day increased HEI-2010 by 1·45–3·59 points (all P<0·005). Conversely, the associations for SF were inconsistent. While SF based on energy contribution was positively associated with HEI-2010 in both children and adolescents (0·70 (P=0·001) and 1·00 (P<0·0001) point increase by one additional snack, respectively), there were no associations for SF based on self-report or time. In analyses in which only plausible energy reporters (3425 children and 3753 adolescents) were included, similar results were obtained.ConclusionsIn a representative sample of US children and adolescents, MF was associated with better diet quality, while the associations for SF varied depending on the definition of snacks. The findings highlight the importance of applying different definitions of meals and snacks when assessing the impact of dietary patterns on health.
How does the pharmaceutical industry influence prescription? A qualitative study of provider payment incentives and drug remunerations in hospitals in Shanghai
Authors: Yang Wei 
Published: February 2016

AbstractOver-prescription has become one major problem in China’s health care sector. Incorporating interview data from hospitals in Shanghai, this paper provided empirical evidence on how the process of over-prescription was carried out in day-to-day clinical settings, and demonstrates various mechanisms that allow over-prescription to continue vigorously in the context of the Chinese health care system. In particular, this study identified four levels of incentives that over-prescription was carried out: hospital, medical department, doctors and pharmaceutical companies. Due to the insufficient funding from the government and rising operational costs, hospitals had to rely on the sales of drugs and provision of medical services to survive. This funding pressure then transferred to specific revenue targets for medical departments. A combination of incentives, including drug remunerations, bonus system, low pay and high workloads motivated over-prescription at doctor level. At pharmaceutical company level, high profits of pharmaceuticals products as well as lack of emphasis on efficacy of drugs led to under-table payments and illicit drug remunerations. The study argued that the way that the Chinese health care system operates was based on the profit-seeking principle rather than on fulfilling its social functions, and called for a systematic reform of provider incentives to eradicating the problem of over-prescription.
Hobbes's Paradoxical Toleration:Inter regentes tolerantia, tolerans intolerantia inter plebem
Authors: Higgins Nicholas 
Published: February 2016

AbstractThe source of Hobbes's liberal view of toleration is a recognized paradox within his absolutist political sovereign. This article argues that Hobbes's view of toleration is consistent with his overall political theory based upon his broader religious teaching, which leads to an epistemological skepticism on the veracity of religion, and as such among rulers toleration is not only allowed, but necessary. Further, this article argues that the inability of the sovereign to punish the private conscience of the citizen derives from natural right and the inherent limitation of law. Finally, this article examines Hobbes's use of religious argumentation to support the inability of a believer to challenge or deviate from the religious commands of the sovereign.
Street Power: Friday Prayers, Islamist Protests, and Islamization in Pakistan
Authors: Butt Ahsan I. 
Published: February 2016

AbstractThis article addresses Pakistani Islamists' street power — their ability to organize rallies, protests, and demonstrations. Building on research on religion and collective action, I first demonstrate how Friday prayers aid Islamist mobilization. Mosques on Friday serve as a filtering and coordination tool, as tactical “choke” points in urban neighborhoods, and as incitement through the imam's sermon. I then show how Islamist street power affects Islamization in Pakistan. I argue that Pakistan's foundational religious nationalism acts as an “opportunity structure,” and affords Islamists agenda-setting and veto power. The success of Islamist agitation depends on the issue contested, the type of regime targeted, and the era in which it is practiced. I use interviews, participant observation at Islamist rallies, an original dataset of all rallies and protests in Pakistan from 2005 to 2010 (n= 4123); and government and local newspaper reports from the 1940s onward to buttress my claims.
Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry
Authors: Singh Ajay K. , Ko Dong-Hyeon , Vishwakarma Niraj K. , Jang Seungwook , Min Kyoung-Ik , Kim Dong-Pyo 
Published: February 2016

AbstractExploration and expansion of the chemistries involving toxic or carcinogenic reagents are severely limited by the health hazards their presence poses. Here, we present a micro-total envelope system (μ-TES) and an automated total process for the generation of the carcinogenic reagent, its purification and its utilization for a desired synthesis that is totally enveloped from being exposed to the carcinogen. A unique microseparator is developed on the basis of SiNWs structure to replace the usual exposure-prone distillation in separating the generated reagent. Chloromethyl methyl ether chemistry is explored as a carcinogenic model in demonstrating the efficiency of the μ-TES that is fully automated so that feeding the ingredients for the generation is all it takes to produce the desired product. Syntheses taking days can be accomplished safely in minutes with excellent yields, which bodes well for elevating the carcinogenic chemistry to new unexplored dimensions.
RUNX1 prevents oestrogen-mediated AXIN1 suppression and β-catenin activation in ER-positive breast cancer
Authors: Chimge Nyam-Osor , Little Gillian H. , Baniwal Sanjeev K. , Adisetiyo Helty , Xie Ying , Zhang Tian , O’Laughlin Andie , Liu Zhi Y. , Ulrich Peaches , Martin Anthony , Mhawech-Fauceglia Paulette , Ellis Matthew J. , Tripathy Debu , Groshen Susan , Liang Chengyu , Li Zhe , Schones Dustin E. , Frenkel Baruch 
Published: February 2016

AbstractRecent high-throughput studies revealed recurrentRUNX1mutations in breast cancer, specifically in oestrogen receptor-positive (ER+) tumours. However, mechanisms underlying the implied RUNX1-mediated tumour suppression remain elusive. Here, by depleting mammary epithelial cells of RUNX1in vivoandin vitro,we demonstrate combinatorial regulation ofAXIN1by RUNX1 and oestrogen. RUNX1 and ER occupy adjacent elements inAXIN1’s second intron, and RUNX1 antagonizes oestrogen-mediatedAXIN1suppression. Accordingly, RNA-seq and immunohistochemical analyses demonstrate an ER-dependent correlation between RUNX1 and AXIN1 in tumour biopsies. RUNX1 loss in ER+mammary epithelial cells increases β-catenin, deregulates mitosis and stimulates cell proliferation and expression of stem cell markers. However, it does not stimulate LEF/TCF,c-MycorCCND1,and it does not accelerate G1/S cell cycle phase transition. Finally, RUNX1 loss-mediated deregulation of β-catenin and mitosis is ameliorated by AXIN1 stabilizationin vitro, highlighting AXIN1 as a potential target for the management of ER+breast cancer.
Relationship between premature loss of primary teeth with oral hygiene, consumption of soft drinks, dental care and previous caries experience
Authors: López-Gómez Sandra Aremy , Villalobos-Rodelo Juan José , Ávila-Burgos Leticia , Casanova-Rosado Juan Fernando , Vallejos-Sánchez Ana Alicia , Lucas-Rincón Salvador Eduardo , Patiño-Marín Nuria , Medina-Solís Carlo Eduardo 
Published: February 2016

AbstractWe determine the relationship between premature loss of primary teeth and oral hygiene, consumption of soft drinks, dental care and previous caries experience. This study focused on 833 Mexican schoolchildren aged 6–7. We performed an oral examination to determine caries experience and the simplified oral hygiene index. The dependent variable was the prevalence of at least one missing tooth (or indicated for extraction) of the primary dentition; this variable was coded as 0 = no loss of teeth and 1 = at least one lost primary tooth. The prevalence of at least one missing tooth was 24.7% (n = 206) (95% CI = 21.8–27.7). The variables that were associated with the prevalence of tooth loss (p < 0.05) included: the largest number of decayed teeth (OR = 1.11), the largest number of filled teeth (OR = 1.23), the worst oral hygiene (OR = 3.24), a lower frequency of brushing (OR = 1.60), an increased consumption of soda (OR = 1.89) and use of dental care (curative: OR = 2.83, preventive: OR = 1.93). This study suggests that the premature loss of teeth in the primary dentition is associated with oral hygiene, consumption of soft drinks, dental care and previous caries experience in Mexican schoolchildren. These data provide relevant information for the design of preventive dentistry programs.
A Micro-Thermal Sensor for Focal Therapy Applications
Authors: Natesan Harishankar , Hodges Wyatt , Choi Jeunghwan , Lubner Sean , Dames Chris , Bischof John 
Published: February 2016

AbstractThere is an urgent need for sensors deployed during focal therapies to inform treatment planning and in vivo monitoring in thin tissues. Specifically, the measurement of thermal properties, cooling surface contact, tissue thickness, blood flow and phase change with mm to sub mm accuracy are needed. As a proof of principle, we demonstrate that a micro-thermal sensor based on the supported “3ω” technique can achieve this in vitro under idealized conditions in 0.5 to 2 mm thick tissues relevant to cryoablation of the pulmonary vein (PV). To begin with “3ω” sensors were microfabricated onto flat glass as an idealization of a focal probe surface. The sensor was then used to make new measurements of ‘k’ (W/m.K) of porcine PV, esophagus, and phrenic nerve, all needed for PV cryoabalation treatment planning. Further, by modifying the sensor use from traditional to dynamic mode new measurements related to tissue vs. fluid (i.e. water) contact, fluid flow conditions, tissue thickness, and phase change were made. In summary, the in vitro idealized system data presented is promising and warrants future work to integrate and test supported “3ω” sensors on in vivo deployed focal therapy probe surfaces (i.e. balloons or catheters).
Evaluation of the antinociceptive activities of enaminone compounds on the formalin and hot plate tests in mice
Authors: Masocha Willias , Kombian Samuel B. , Edafiogho Ivan O. 
Published: February 2016

AbstractRecently, we found that methyl 4-(4′-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate (E139), an anticonvulsant enaminone, has antinociceptive activity in the hot plate test. In this study we evaluated the antinociceptive activity of five anilino enaminones E139, ethyl 4-(4′-chlorophenyl)amino-6-methyl-2-oxocyclohex-3-en-1-oate (E121), ethyl 4-(4′-bromophenyl)amino-6-methyl-2-oxocyclohex-3-en-1-oate (E122), methyl 4-(4′-chlorophenyl)amino-6-methyl-2-oxocyclohex-3-en-1-oate (E138) and ethyl 4-(4′-fluorophenyl)amino-6-methyl-2-oxocyclohex-3-en-1-oate (BRG 19) using the formalin and hot plate tests. E139 has been reported to exert its effects via enhancement of extracellular GABA levels, thus tiagabine, a GABA transporter inhibitor, was evaluated as a control together with indomethacin. Tiagabine had antinociceptive activity in both phase 1 (neurogenic pain) and phase 2 (inflammatory pain) of the formalin test, whereas indomethacin had activity only in phase 2. E139 and E138 had antinociceptive activity in both phases of the formalin test, whereas E121 had activity only in phase 1 and BRG 19 had activity only in phase 2. E122 had no significant activity in either phase. In the hot plate test only E139 had antinociceptive activity. Administration of either bicuculline, a GABAAreceptor antagonist, or CGP 35348, a GABABreceptor antagonist, blocked the antinociceptive activity of E139. In conclusion our results indicate that E139 has antinociceptive activity in the formalin and hot plate tests that are dependent on GABA receptors.
Adaptive Optical Scanning Holography
Authors: Tsang P. W. M. , Poon Ting-Chung , Liu J.-P. 
Published: February 2016

AbstractOptical Scanning Holography (OSH) is a powerful technique that employs a single-pixel sensor and a row-by-row scanning mechanism to capture the hologram of a wide-view, three-dimensional object. However, the time required to acquire a hologram with OSH is rather lengthy. In this paper, we propose an enhanced framework, which is referred to as Adaptive OSH (AOSH), to shorten the holographic recording process. We have demonstrated that the AOSH method is capable of decreasing the acquisition time by up to an order of magnitude, while preserving the content of the hologram favorably.
Touch influences perceived gloss
Authors: Adams Wendy J. , Kerrigan Iona S. , Graf Erich W. 
Published: February 2016

AbstractIdentifying an object’s material properties supports recognition and action planning: we grasp objects according to how heavy, hard or slippery we expect them to be. Visual cues to material qualities such as gloss have recently received attention, but how they interact with haptic (touch) information has been largely overlooked. Here, we show that touch modulates gloss perception: objects that feel slippery are perceived as glossier (more shiny).Participants explored virtual objects that varied in look and feel. A discrimination paradigm (Experiment 1) revealed that observers integrate visual gloss with haptic information. Observers could easily detect an increase in glossiness when it was paired with a decrease in friction. In contrast, increased glossiness coupled with decreased slipperiness produced a small perceptual change: the visual and haptic changes counteracted each other. Subjective ratings (Experiment 2) reflected a similar interaction – slippery objects were rated as glossier and vice versa. The sensory system treats visual gloss and haptic friction as correlated cues to surface material. Although friction is not a perfect predictor of gloss, the visual system appears to know and use a probabilistic relationship between these variables to bias perception – a sensible strategy given the ambiguity of visual clues to gloss.
Multifrequency Force Microscopy of Helical Protein Assembly on a Virus
Authors: Calò Annalisa , Eleta-Lopez Aitziber , Stoliar Pablo , De Sancho David , Santos Sergio , Verdaguer Albert , Bittner Alexander M. 
Published: February 2016

AbstractHigh-resolution microscopy techniques have been extensively used to investigate the structure of soft, biological matter at the nanoscale, from very thin membranes to small objects, like viruses. Electron microscopy techniques allow for obtaining extraordinary resolution by averaging signals from multiple identical structures. In contrast, atomic force microscopy (AFM) collects data from single entities. Here, it is possible to finely modulate the interaction with the samples, in order to be sensitive to their top surface, avoiding mechanical deformations. However, most biological surfaces are highly curved, such as fibers or tubes and ultimate details of their surface are in the vicinity of steep height variations. This limits lateral resolution, even when sharp probes are used. We overcome this problem by using multifrequency force microscopy on a textbook example, the Tobacco Mosaic Virus (TMV). We achieved unprecedented resolution in local maps of amplitude and phase shift of the second excited mode, recorded together with sample topography. Our data, which combine multifrequency imaging and Fourier analysis, confirm the structure deduced from averaging techniques (XRD, cryoEM) for surface features of single virus particles, down to the helical pitch of the coat protein subunits, 2.3 nm. Remarkably, multifrequency AFM images do not require any image postprocessing.
Substrate-dependent dynamics of the multidrug efflux transporter AcrB of Escherichia coli
Authors: Yamamoto Kentaro , Tamai Rei , Yamazaki Megumi , Inaba Takehiko , Sowa Yoshiyuki , Kawagishi Ikuro 
Published: February 2016

AbstractThe resistance-nodulation-cell division (RND)-type xenobiotic efflux system plays a major role in the multidrug resistance of gram-negative bacteria. The only constitutively expressed RND system of Escherichia coli consists of the inner membrane transporter AcrB, the membrane fusion protein AcrA, and the outer membrane channel TolC. The latter two components are shared with another RND-type transporter AcrD, whose expression is induced by environmental stimuli. Here, we demonstrate how RND-type ternary complexes, which span two membranes and the cell wall, form in vivo. Total internal reflection fluorescence (TIRF) microscopy revealed that most fluorescent foci formed by AcrB fused to green fluorescent protein (GFP) were stationary in the presence of TolC but showed lateral displacements when tolC was deleted. The fraction of stationary AcrB-GFP foci decreased with increasing levels of AcrD. We propose that the AcrB-containing complex becomes unstable upon the induction of AcrD, which presumably replaces AcrB, a process we call “transporter exchange.” This instability is suppressed by AcrB-specific substrates, suggesting that the ternary complex is stabilised when it is in action. These results suggest that the assembly of the RND-type efflux system is dynamically regulated in response to external stimuli, shedding new light on the adaptive antibiotic resistance of bacteria.
Synergistic Effect of Cold Atmospheric Plasma and Drug Loaded Core-shell Nanoparticles on Inhibiting Breast Cancer Cell Growth
Authors: Zhu Wei , Lee Se-Jun , Castro Nathan J. , Yan Dayun , Keidar Michael , Zhang Lijie Grace 
Published: February 2016

AbstractNano-based drug delivery devices allowing for effective and sustained targeted delivery of therapeutic agents to solid tumors have revolutionized cancer treatment. As an emerging biomedical technique, cold atmospheric plasma (CAP), an ionized non-thermal gas mixture composed of various reactive oxygen species, reactive nitrogen species and UV photons, shows great potential for cancer treatment. Here we seek to develop a new dual cancer therapeutic method by integrating promising CAP and novel drug loaded core-shell nanoparticles and evaluate its underlying mechanism for targeted breast cancer treatment. For this purpose, core-shell nanoparticles were synthesized via co-axial electrospraying. Biocompatible poly (lactic-co-glycolic acid) was selected as the polymer shell to encapsulate anti-cancer therapeutics. Results demonstrated uniform size distribution and high drug encapsulation efficacy of the electrosprayed nanoparticles. Cell studies demonstrated the effectiveness of drug loaded nanoparticles and CAP for synergistic inhibition of breast cancer cell growth when compared to each treatment separately. Importantly, we found CAP induced down-regulation of metastasis related gene expression (VEGF, MTDH, MMP9 and MMP2) as well as facilitated drug loaded nanoparticle uptake which may aid in minimizing drug resistance-a major problem in chemotherapy. Thus, the integration of CAP and drug encapsulated nanoparticles provides a promising tool for the development of a new cancer treatment strategy.
Vortex ring behavior provides the epigenetic blueprint for the human heart
Authors: Arvidsson Per M. , Kovács Sándor J. , Töger Johannes , Borgquist Rasmus , Heiberg Einar , Carlsson Marcus , Arheden Håkan 
Published: February 2016

AbstractThe laws of fluid dynamics govern vortex ring formation and precede cardiac development by billions of years, suggesting that diastolic vortex ring formation is instrumental in defining the shape of the heart. Using novel and validated magnetic resonance imaging measurements, we show that the healthy left ventricle moves in tandem with the expanding vortex ring, indicating that cardiac form and function is epigenetically optimized to accommodate vortex ring formation for volume pumping. Healthy hearts demonstrate a strong coupling between vortex and cardiac volumes (R2 = 0.83), but this optimized phenotype is lost in heart failure, suggesting restoration of normal vortex ring dynamics as a new and possibly important consideration for individualized heart failure treatment. Vortex ring volume was unrelated to early rapid filling (E-wave) velocity in patients and controls. Characteristics of vortex-wall interaction provide unique physiologic and mechanistic information about cardiac diastolic function that may be applied to guide the design and implantation of prosthetic valves and have potential clinical utility as therapeutic targets for tailored medicine or measures of cardiac health.
An evolutionary game approach for determination of the structural conflicts in signed networks
Authors: Tan Shaolin , Lü Jinhu 
Published: February 2016

AbstractSocial or biochemical networks can often divide into two opposite alliances in response to structural conflicts between positive (friendly, activating) and negative (hostile, inhibiting) interactions. Yet, the underlying dynamics on how the opposite alliances are spontaneously formed to minimize the structural conflicts is still unclear. Here, we demonstrate that evolutionary game dynamics provides a felicitous possible tool to characterize the evolution and formation of alliances in signed networks. Indeed, an evolutionary game dynamics on signed networks is proposed such that each node can adaptively adjust its choice of alliances to maximize its own fitness, which yet leads to a minimization of the structural conflicts in the entire network. Numerical experiments show that the evolutionary game approach is universally efficient in quality and speed to find optimal solutions for all undirected or directed, unweighted or weighted signed networks. Moreover, the evolutionary game approach is inherently distributed. These characteristics thus suggest the evolutionary game dynamic approach as a feasible and effective tool for determining the structural conflicts in large-scale on-line signed networks.