bluuebunny/crossref_metadata_2025_split huggingface dataset:
Scheelite (CaWO4)-type microphosphors: Facile synthesis, structural characterization and photoluminescence properties
Authors: Han Yuanyuan , Wang Dan , Liang Danyang , Wang Shiqi , Lu Guoxin , Wang Xiaoyu , Pei Nana 
Published: December 2016

Scheelite (CaWO4)-type microphosphors were synthesized by the precipitation method assisted with cetyltrimethyl ammonium bromide (CTAB). All compounds crystallized in the tetragonal structure with space group [Formula: see text] (No. 88). FE-SEM micrographs illustrate the spherical-like morphologies and rough surface. PL spectra indicate the broad emission peak maximum at 613 nm under UV excitation. Luminescence decay curves monitored by [Formula: see text] transition ([Formula: see text] nm) of Eu[Formula: see text] in doped CaWO4 are presented, the curves exhibit a single-exponential feature and the lifetime for doped CaWO4 is 0.61 ms.
Castration alters protein balance after high-frequency muscle contraction
Authors: Steiner Jennifer L. , Fukuda David H. , Rossetti Michael L. , Hoffman Jay R. , Gordon Bradley S. 
Published: December 2016

Resistance exercise increases muscle mass by shifting protein balance in favor of protein accretion. Androgens independently alter protein balance, but it is unknown whether androgens alter this measure after resistance exercise. To answer this, male mice were subjected to sham or castration surgery 7–8 wk before undergoing a bout of unilateral, high-frequency, electrically induced muscle contractions in the fasted or refed state. Puromycin was injected 30 min before euthanasia to measure protein synthesis. The tibialis anterior was analyzed 4 h postcontraction. In fasted mice, neither basal nor stimulated rates of protein synthesis were affected by castration despite lower phosphorylation of mechanistic target of rapamycin in complex 1 (mTORC1) substrates [p70S6K1 (Thr389) and 4E-BP1 (Ser65)]. Markers of autophagy (LC3 II/I ratio and p62 protein content) were elevated by castration, and these measures remained elevated above sham values after contractions. Furthermore, in fasted mice, the protein content of Regulated in Development and DNA Damage 1 (REDD1) was correlated with LC3 II/I in noncontracted muscle, whereas phosphorylation of uncoordinated like kinase 1 (ULK1) (Ser757) was correlated with LC3 II/I in the contracted muscle. When mice were refed before contractions, protein synthesis and mTORC1 signaling were not affected by castration in either the noncontracted or contracted muscle. Conversely, markers of autophagy remained elevated in the muscles of refed, castrated mice even after contractions. These data suggest the castration-mediated elevation in baseline autophagy reduces the absolute positive shift in protein balance after muscle contractions in the refed or fasted states. NEW & NOTEWORTHY In the absence of androgens, markers of autophagy were elevated, and these could not be normalized by muscle contractions. In the fasted state, REDD1 was identified as a potential contributor to autophagy in noncontracted muscle, whereas phosphorylation of ULK1 may contribute to this process in the contracted muscle. In the refed state, markers of autophagy remain elevated in both noncontracted and contracted muscles, but the relationship with REDD1 and ULK1 (Ser757) no longer existed.
Cdk5 Directly Targets Nuclear p21CIP1 and Promotes Cancer Cell Growth
Authors: Huang Pao-Hsuan , Chen Mei-Chih , Peng Yu-Ting , Kao Wei-Hsiang , Chang Chih-Hsiang , Wang Yun-Chi , Lai Chih-Ho , Hsieh Jer-Tsong , Wang Jo-Hsin , Lee Yueh-Tsung , Lin Eugene , Yue Chia-Herng , Wang Hsin-Yi , You Shuen-Chi , Lin Ho 
Published: December 2016

Abstract
The significance of Cdk5 in cell-cycle control and cancer biology has gained increased attention. Here we report the inverse correlation between the protein levels of Cdk5 and p21CIP1 from cell-based and clinical analysis. Mechanistically, we identify that Cdk5 overexpression triggers the proteasome-dependent degradation of p21CIP1 through a S130 phosphorylation in a Cdk2-independent manner. Besides, the evidence from cell-based and clinical analysis shows that Cdk5 primarily regulates nuclear p21CIP1 protein degradation. S130A-p21CIP1 mutant enables to block either its protein degradation or the increase of cancer cell growth caused by Cdk5. Notably, Cdk5-triggered p21CIP1 targeting primarily appears in S-phase, while Cdk5 overexpression increases the activation of Cdk2 and its interaction with DNA polymerase δ. The in vivo results show that Cdk2 might play an important role in the downstream signaling to Cdk5. In summary, these findings suggest that Cdk5 in a high expression status promotes cancer growth by directly and rapidly releasing p21CIP1-dependent cell-cycle inhibition and subsequent Cdk2 activation, which illustrates an oncogenic role of Cdk5 potentially applied for future diagnosis and therapy. Cancer Res; 76(23); 6888–900. ©2016 AACR.
The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia
Authors: Herman Sarah E.M. , Montraveta Arnau , Niemann Carsten U. , Mora-Jensen Helena , Gulrajani Michael , Krantz Fanny , Mantel Rose , Smith Lisa L. , McClanahan Fabienne , Harrington Bonnie K. , Colomer Dolors , Covey Todd , Byrd John C. , Izumi Raquel , Kaptein Allard , Ulrich Roger , Johnson Amy J. , Lannutti Brian J. , Wiestner Adrian , Woyach Jennifer A. 
Published: December 2016

Abstract
Purpose: Acalabrutinib (ACP-196) is a novel, potent, and highly selective Bruton tyrosine kinase (BTK) inhibitor, which binds covalently to Cys481 in the ATP-binding pocket of BTK. We sought to evaluate the antitumor effects of acalabrutinib treatment in two established mouse models of chronic lymphocytic leukemia (CLL).
Experimental Design: Two distinct mouse models were used, the TCL1 adoptive transfer model where leukemic cells from Eμ-TCL1 transgenic mice are transplanted into C57BL/6 mice, and the human NSG primary CLL xenograft model. Mice received either vehicle or acalabrutinib formulated into the drinking water.
Results: Utilizing biochemical assays, we demonstrate that acalabrutinib is a highly selective BTK inhibitor as compared with ibrutinib. In the human CLL NSG xenograft model, treatment with acalabrutinib demonstrated on-target effects, including decreased phosphorylation of PLCγ2, ERK, and significant inhibition of CLL cell proliferation. Furthermore, tumor burden in the spleen of the mice treated with acalabrutinib was significantly decreased compared with vehicle-treated mice. Similarly, in the TCL1 adoptive transfer model, decreased phosphorylation of BTK, PLCγ2, and S6 was observed. Most notably, treatment with acalabrutinib resulted in a significant increase in survival compared with mice receiving vehicle.
Conclusions: Treatment with acalabrutinib potently inhibits BTK in vivo, leading to on-target decreases in the activation of key signaling molecules (including BTK, PLCγ2, S6, and ERK). In two complementary mouse models of CLL, acalabrutinib significantly reduced tumor burden and increased survival compared with vehicle treatment. Overall, acalabrutinib showed increased BTK selectivity compared with ibrutinib while demonstrating significant antitumor efficacy in vivo on par with ibrutinib. Clin Cancer Res; 23(11); 2831–41. ©2016 AACR.
A “Total War”? Rethinking Military Ideology in the Book of Lord Shang
Authors: Pines Yuri 
Published: December 2016

TheBook of Lord Shang, commonly identified as a major work of the so-called Legalist school, is also an important, albeit much neglected treatise in the history of Chinese military thought. Beyond specific recommendations concerning both defensive and offensive warfare, the book presents a coherent view that the state should restructure its socioeconomic and cultural policies in order to turn every man into a valiant soldier. The book epitomizes the ideology of “total war” in which the differences between civilian and military affairs are blurred. The society is profoundly militarized and the army, in turn, is profoundly bureaucratized.This article explores military thought in theBook of Lord Shangand focuses on its views of mobilization, indoctrination of soldiers, military discipline, rules of military engagement, and military command. I further deal with the question of why the book’s military ideology has been all but neglected after the end of the Han dynasty.
A method to estimate the heating and cooling degree-days for different climatic zones of Saudi Arabia
Authors: Indraganti Madhavi , Boussaa Djamel 
Published: December 2016

Saudi Arabia’s energy consumption is increasing astronomically. Saudi Building Code prescribes a fixed base temperature of 18.3℃ to estimate the heating degree-days and cooling degree-days. Using historical meteorological data (2005–2014), this article presents the heating degree-days and cooling degree-days estimated for the representative cities in all the five inhabited climatic zones of Saudi Arabia. We used the base temperatures of 14℃, 16℃ and 18℃ for heating degree-days, and 18℃, 20℃, 22℃, 24℃ and 28℃ for cooling degree-days for Dhahran, Guriat, Jeddah, Khamis Mushait and Riyadh cities. We developed multiple regression models for heating degree-days and cooling degree-days at various base temperatures for these zones. Degree-days for other cities in similar climates with limited input data can be computed with these. Lowering of base temperature by 2 K from 18℃ reduced the heating degree-days by 33–65%. At 14℃ of base temperature, the heating requirement reduced by 60–95%. Elevating the base temperature by 2 K from 18℃ lowered the cooling degree-days by 16–38%. At 28℃ of base temperature cooling can be completely eliminated in Khamis Mushait, and reduced by 65–92% in other cities. This observation merits rethinking about use of appropriate base temperatures that properly link the outdoor environment to reduce the energy consumption. Practical application: Using historical data, we developed regression models for predicting heating and cooling degree-days for five cities of Saudi Arabia in various climate zones without the historic data. Using these, we can estimate the changes in heating/cooling load due to the variation in base temperatures. For example, lowering base temperature by 2–4 K from 18℃ reduces the HDDs by 33–95% and elevating the base temperature by 2–4 K from 18℃ lowered the CDDs by 16–68%.
Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial
Authors: Griffiths Roland R , Johnson Matthew W , Carducci Michael A , Umbricht Annie , Richards William A , Richards Brian D , Cosimano Mary P , Klinedinst Margaret A 
Published: December 2016

Cancer patients often develop chronic, clinically significant symptoms of depression and anxiety. Previous studies suggest that psilocybin may decrease depression and anxiety in cancer patients. The effects of psilocybin were studied in 51 cancer patients with life-threatening diagnoses and symptoms of depression and/or anxiety. This randomized, double-blind, cross-over trial investigated the effects of a very low (placebo-like) dose (1 or 3 mg/70 kg) vs. a high dose (22 or 30 mg/70 kg) of psilocybin administered in counterbalanced sequence with 5 weeks between sessions and a 6-month follow-up. Instructions to participants and staff minimized expectancy effects. Participants, staff, and community observers rated participant moods, attitudes, and behaviors throughout the study. High-dose psilocybin produced large decreases in clinician- and self-rated measures of depressed mood and anxiety, along with increases in quality of life, life meaning, and optimism, and decreases in death anxiety. At 6-month follow-up, these changes were sustained, with about 80% of participants continuing to show clinically significant decreases in depressed mood and anxiety. Participants attributed improvements in attitudes about life/self, mood, relationships, and spirituality to the high-dose experience, with >80% endorsing moderately or greater increased well-being/life satisfaction. Community observer ratings showed corresponding changes. Mystical-type psilocybin experience on session day mediated the effect of psilocybin dose on therapeutic outcomes. Trial Registration ClinicalTrials.gov identifier: NCT00465595
Acoustics measurements of military-style supersonic beveled nozzle jets with interior corrugations
Authors: Powers Russell W , McLaughlin Dennis K 
Published: December 2016

Increasingly powerful and noisy military aircraft have generated the need for research leading to the development of supersonic jet noise reduction devices. The hot, high speed supersonic jets exhausting from military aircraft during takeoff present a most challenging problem. The present study extends prior research on two methods of noise reduction. The first is the internal nozzle corrugations pioneered by Seiner et al. and the second is the beveled exit plane explored most recently by Viswanathan. A novel research idea of creating fluidic corrugations similar to the nozzle corrugations has been initiated by Penn State. To further the understanding and analysis of the fluidic corrugations, the present study focuses on the flow field and acoustic field of nozzles with two, three, and six conventional, hardwalled corrugations. The effect of the combination of the internal corrugations with a beveled nozzle is explored. The results show that significant noise reductions of over 3 dB of the mixing noise and the broadband shock-associated noise can be achieved. The combination of the beveled nozzle and the internal nozzle corrugations showed that there is less azimuthal dependence of the acoustic field than for the purely beveled nozzle. The combination nozzle was shown to reduce the noise over a wider range of polar angles and operating conditions than either the purely beveled nozzle or the purely corrugated nozzle.
Laparoscopic approach to splenic aneurysms
Authors: Małczak Piotr , Wysocki Michał , Major Piotr , Pędziwiatr Michał , Lasek Anna , Stefura Tomasz , Radkowiak Dorota , Zub-Pokrowiecka Anna , Budzyński Andrzej 
Published: December 2016

Background Splenic artery aneurysm is a rare disease with possibly mortal complications. For years, the main method of treatment was excision of aneurysm with spleen. In recent years, several methods have been developed in order to salvage the spleen such endovascular techniques and aneurysmectomy. Objective The aim of our study was to determine the feasibility of laparoscopic aneurysmectomy with spleen salvage in cases of splenic artery aneurysm. Materials Analysis of prospectively gathered data containing records of patients operated laparoscopically due to diseases of the spleen in 1998–2016 in our department. Inclusion criteria were attempted laparoscopic aneurysmectomy with intent to salvage spleen. Results Out of 11 patients, seven patients underwent aneurysmectomy with spleen preservation, one patient had partial-splenectomy, two patients had intra-operative splenectomies and one patient had a re-operation on post-op day 1 with splenectomy. Re-operation with splenectomy was the only recorded complication. Conclusions Laparoscopic aneurysmectomy of SAA may be considered as a safe treatment method, with good short- and long-term results; however, a complete evaluation requires further research on a larger study group. It allows permanent treatment of SAA with maintaining spleen function.
POST-NOAC: Portuguese observational study of intracranial hemorrhage on non-vitamin K antagonist oral anticoagulants
Authors: Marques-Matos Cláudia , Alves José Nuno , Marto João Pedro , Ribeiro Joana Afonso , Monteiro Ana , Araújo José , Silva Fernando , Grenho Fátima , Viana-Baptista Miguel , Sargento-Freitas João , Pinho João , Azevedo Elsa 
Published: December 2016

Background There is a lower reported incidence of intracranial hemorrhage with non-vitamin K antagonist oral anticoagulants compared with vitamin K antagonist. However, the functional outcome and mortality of intracranial hemorrhage patients were not assessed. Aims To compare the outcome of vitamin K antagonists- and non-vitamin K antagonist oral anticoagulants-related intracranial hemorrhage. Methods We included consecutive patients with acute non-traumatic intracranial hemorrhage on oral anticoagulation therapy admitted between January 2013 and June 2015 at four university hospitals. Clinical and demographic data were obtained from individual medical records. Intracranial hemorrhage was classified as intracerebral, extra-axial, or multifocal using brain computed tomography. Three-month functional outcome was assessed using the modified Rankin Scale. Results Among 246 patients included, 24 (9.8%) were anticoagulated with a non-vitamin K antagonist oral anticoagulants and 222 (90.2%) with a vitamin K antagonists. Non-vitamin K antagonist oral anticoagulants patients were older (81.5 vs. 76 years, p = 0.048) and had intracerebral hemorrhage more often (83.3% vs. 63.1%, p = 0.048). We detected a non-significant trend for larger intracerebral hemorrhage volumes in vitamin K antagonists patients ( p = 0.368). Survival analysis adjusted for age, CHA2DS2VASc, HAS-BLED, and anticoagulation reversal revealed that non-vitamin K antagonist oral anticoagulants did not influence three-month mortality (hazard ratio (HR) = 0.83, 95% confidence interval (CI) = 0.39–1.80, p = 0.638). Multivariable ordinal regression for three-month functional outcome did not show a significant shift of modified Rankin Scale scores in non-vitamin K antagonist oral anticoagulants patients (odds ratio (OR) 1.26, 95%CI 0.55–2.87, p = 0.585). Conclusions We detected no significant differences in the three-month outcome between non-vitamin K antagonist oral anticoagulants- and vitamin K antagonists-associated intracranial hemorrhage, despite unavailability of non-vitamin K antagonist oral anticoagulants-specific reversal agents.
Crescentic Osteotomy for Revision Hallux Interphalangeal Joint Arthrodesis
Authors: Franklin Andrew , McKee Patrick , Claessens Joris 
Published: December 2016

Treatment for rigid mallet toe deformity of the hallux has commonly consisted of arthrodesis of this interphalangeal joint. However, such procedure is not without complications resulting in operative revision. We report on a case of considerable deformity of the distal phalanx of the hallux following hallux interphalangeal joint arthrodesis that underwent revision using a unique crescentic osteotomy technique. Levels of Evidence: Level V: Case report/Technique
Effectiveness of a low-cost body weight support training device in the rehabilitation of cerebral palsy
Authors: Sharan Deepak , Rajkumar Joshua Samuel , Balakrishnan Rajarajeshwari , Kulkarni Amruta , Selvakumar Kalpana , Gampa Sivakrishna , Mohandoss Mathankumar , Ranganathan Rameshkumar 
Published: December 2016

Background Body weight supported treadmill training (BWSTT) has been proven to be effective in rehabilitation of persons with cerebral palsy (CP). However, it has still not found widespread usage, especially in industrially developing countries, due to its high cost. Treadmill training promotes a rhythmical movement of the lower extremities through motor learning, which can be enhanced by BWSTT for persons with CP. Hence, the research and development team of a tertiary level neuromusculoskeletal rehabilitation center designed a low-cost body weight support training (BWST) device. The aim of this study was to evaluate the effectiveness of the BWST device on gait and ambulation in persons with CP post single-event multilevel surgery (SEMLS) of the lower extremities. Method A randomized controlled trial was conducted in 50 persons with CP aged between 5 and 20 years, who underwent a type of SEMLS called single-event multilevel lever arm restoration and anti-spasticity surgery (SEMLARASS). They were randomly assigned to two groups: group A ( n = 25) received gait training and treadmill training with the BWST device, and group B ( n = 25) received gait training and treadmill training without the BWST device. The designed BWST device was manually operated and based on an un-weighing principle in which a vest of different sizes un-weighed 10–30% of the individual’s weight transmitted to the ground by means of adjustable counterweights fixed on a movable metallic frame which had an adjustable top lever (holding the vest) and a handle bar for the patient to hold. The entire cost for the finished BWST device was estimated around 700 USD. The study duration was 5 weeks with 1 h of intervention per day for 6 days per week. Physician Rating Scale (PRS), Dynamic Gait Index (DGI) and Functional Mobility Scale (FMS) were the primary outcome measures. Results Group A showed significant positive differences in the scores of PRS ( p < 0.001), DGI ( p < 0.001) and FMS ( p < 0.01) when compared with group B, 5 weeks after the intervention, and the results were maintained at a follow-up of 12 months. Conclusion The low-cost BWST device was found to be clinically effective in improving gait and ambulation in persons with CP following SEMLARASS.
Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia
Authors: Grever Michael R. , Abdel-Wahab Omar , Andritsos Leslie A. , Banerji Versha , Barrientos Jacqueline , Blachly James S. , Call Timothy G. , Catovsky Daniel , Dearden Claire , Demeter Judit , Else Monica , Forconi Francesco , Gozzetti Alessandro , Ho Anthony D. , Johnston James B. , Jones Jeffrey , Juliusson Gunnar , Kraut Eric , Kreitman Robert J. , Larratt Loree , Lauria Francesco , Lozanski Gerard , Montserrat Emili , Parikh Sameer A. , Park Jae H. , Polliack Aaron , Quest Graeme R. , Rai Kanti R. , Ravandi Farhad , Robak Tadeusz , Saven Alan , Seymour John F. , Tadmor Tamar , Tallman Martin S. , Tam Constantine , Tiacci Enrico , Troussard Xavier , Zent Clive S. , Zenz Thorsten , Zinzani Pier Luigi , Falini Brunangelo 
Published: December 2016

AbstractHairy cell leukemia is an uncommon hematologic malignancy characterized by pancytopenia and marked susceptibility to infection. Tremendous progress in the management of patients with this disease has resulted in high response rates and improved survival, yet relapse and an appropriate approach to re-treatment present continuing areas for research. The disease and its effective treatment are associated with immunosuppression. Because more patients are being treated with alternative programs, comparison of results will require general agreement on definitions of response, relapse, and methods of determining minimal residual disease. The development of internationally accepted, reproducible criteria is of paramount importance in evaluating and comparing clinical trials to provide optimal care. Despite the success achieved in managing these patients, continued participation in available clinical trials in the first-line and particularly in the relapse setting is highly recommended. The Hairy Cell Leukemia Foundation convened an international conference to provide common definitions and structure to guide current management. There is substantial opportunity for continued research in this disease. In addition to the importance of optimizing the prevention and management of the serious risk of infection, organized evaluations of minimal residual disease and treatment at relapse offer ample opportunities for clinical research. Finally, a scholarly evaluation of quality of life in the increasing number of survivors of this now manageable chronic illness merits further study. The development of consensus guidelines for this disease offers a framework for continued enhancement of the outcome for patients.