bluuebunny/crossref_metadata_2025_split huggingface dataset:
Consensus of linear multi‐agent systems subject to communication delays and switching networks
Authors: Lu Maobin , Liu Lu 
Published: January 2017

SummaryIn this paper, the consensus problem for linear multi‐agent systems subject to nonuniform time‐varying communication delays and jointly connected switching networks is investigated. Two cases, known communication delay and unknown communication delay, are considered, respectively. For each case, both distributed dynamic state feedback control law and distributed dynamic output feedback control law are proposed. By establishing some technical lemmas, it is shown that the proposed distributed control laws can solve the consensus problem, respectively. Copyright © 2017 John Wiley & Sons, Ltd.
Sustainable Consumption and Value Propositions: Exploring Product–Service System Practices Among Swedish Fashion Firms
Authors: Stål Herman I. , Jansson Johan 
Published: January 2017

AbstractSince sustainable consumption (SC) research focuses primarily on consumer purchasing behaviors, there is a gap regarding how firms attempt to shape sustainable consumption in practice. Utilizing nine case studies, this gap is addressed by exploring the use of value propositions entailing product–service systems among Swedish fashion firms. The value propositions in use by the firms suggest that sustainable consumption may be extending beyond purchase to also include aspects of use and disposal, suggesting new reciprocal responsibilities for firms and consumers. Similarities are found in what elements firms incorporate in their value propositions (i.e. more sustainable textiles, repair and take‐back systems), but differences in how these are elaborated, testifying to the inter‐organizational dynamics that embed practices. The paper ends with the specific caution that take‐back systems may send illusionary signals regarding recycling that legitimize increased consumption and further accelerate material throughput, which would be at odds with notions of strong sustainable consumption. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
A high‐capacity and secure least significant bit embedding approach based on word and letter frequencies
Authors: Alshayeji Mohammad H. , Al‐Roomi Suood Abdulaziz , Abed Sa'ed 
Published: January 2017

AbstractIn this paper, we propose a novel least significant bit embedding approach that capitalizes on the skewed distribution of letter and word frequencies to achieve higher image capacity, quality, and security. We initially conduct a study that involves all of the character frequencies using a data set of 14.245 billion characters. Huffman coding for each character is generated on the basis of its probability of occurrence. Furthermore, the top 100 000 most frequent words are transformed into a smaller ciphertext that has a lower cost. Our work demonstrates that recognizing characters and words on the basis of their frequency patterns and prioritizing them accordingly has a greater prospect of reducing the overall cost of embedding. The proposed scheme significantly outperforms Lempel–Ziv–Welch compression with an average of 45% fewer embedded bits. Moreover, the image quality is improved by a mean peak signal‐to‐noise ratio value of 6.9%. The proposed method also establishes a security embedding by proposing a novel shuffling algorithm. Copyright © 2017 John Wiley & Sons, Ltd.
CA‐ARBAC: privacy preserving using context‐aware role‐based access control on Android permission system
Authors: Abdella J. , Özuysal M. , Tomur E. 
Published: January 2017

AbstractExisting mobile platforms are based on manual way of granting and revoking permissions to applications. Once the user grants a given permission to an application, the application can use it without limit, unless the user manually revokes the permission. This has become the reason for many privacy problems because of the fact that a permission that is harmless at some occasion may be very dangerous at another condition. One of the promising solutions for this problem is context‐aware access control at permission level that allows dynamic granting and denying of permissions based on some predefined context. However, dealing with policy configuration at permission level becomes very complex for the user as the number of policies to configure will become very large. For instance, if there are A applications, P permissions, and C contexts, the user may have to deal with A × P × C number of policy configurations. Therefore, we propose a context‐aware role‐based access control model that can provide dynamic permission granting and revoking while keeping the number of policies as small as possible. Although our model can be used for all mobile platforms, we use Android platform to demonstrate our system. In our model, Android applications are assigned roles where roles contain a set of permissions and contexts are associated with permissions. Permissions are activated and deactivated for the containing role based on the associated contexts. Our approach is unique in that our system associates contexts with permissions as opposed to existing similar works that associate contexts with roles. As a proof of concept, we have developed a prototype application called context‐aware Android role‐based access control. We have also performed various tests using our application, and the result shows that our model is working as desired. Copyright © 2017 John Wiley & Sons, Ltd.
Methane Activation Mediated by Dual Gold Atoms Doped in Aluminium Oxide Cluster Cations Au2Al2O3+
Authors: Zhou Xiao‐Hong , Li Zi‐Yu , Jiang Li‐Xue , He Sheng‐Gui , Ma Tong‐Mei 
Published: January 2017

AbstractThe study of chemical reactions between gold‐doped oxide clusters and methane can provide molecular level mechanisms to understand the activity of gold species supported on metal oxides. The role of single gold atom in methane activation has been identified, while the effect of two or more gold atoms is far from clear. By employing mass spectrometry and theoretical calculations, the reactivity of heteronuclear oxide clusters with dual gold atoms (Au2Al2O3+) toward methane was explored. Three major reaction products with the formation of CH3•, AuCH2, and Au were observed experimentally. Theoretical calculations indicate that Au2Al2O3+ contains two separate gold atoms and one oxygen−centred radical (O−•). Two types of mechanisms for methane activation are identified. The reaction initiated by the O−• site primarily generates the CH3• through hydrogen atom abstraction while the reaction starting from the gold site mainly contributes to the generation of AuCH2 and Au via the mechanism of Lewis acid‐base pairs. It was revealed that the formation of gold dimer species driven by the aurophilic interaction plays an important role in the second C−H bond activation.
Ionic Diodes Based on Regenerated α‐Cellulose Films Deposited Asymmetrically onto a Microhole
Authors: Aaronson Barak D. B. , He Daping , Madrid Elena , Johns Marcus A. , Scott Janet L. , Fan Lian , Doughty James , Kadowaki Marco A. S. , Polikarpov Igor , McKeown Neil B. , Marken Frank 
Published: January 2017

AbstractCellulose films of approximately 5 μm thickness, reconstituted from ionic liquid media onto a poly‐ethylene‐terephthalate (PET) film with a 5, 10, 20, or 40 μm diameter microhole, show current rectification when immersed in aqueous NaCl. For “asymmetric cellulose deposits” this rectification, or ionic diode behaviour, is then investigated as a function of ionic strength and microhole diameter. Future applications are envisaged in sustainable cellulose‐based desalination, sensing, or energy harvesting processes.
Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol‐induced seizures in zebrafish
Authors: Pisera‐Fuster Antonella , Otero Sofía , Talevi Alan , Bruno‐Blanch Luis , Bernabeu Ramón 
Published: January 2017

AbstractScreening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost‐efficient preclinical models applicable to high‐throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of pentylenetetrazole (PTZ)‐induced seizures in zebrafish. Sodium cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.
Resistance to dialogic discourse in SSI teaching: The effects of an argumentation‐based workshop, teaching practicum, and induction on a preservice science teacher
Authors: Kilinc Ahmet , Demiral Umit , Kartal Tezcan 
Published: January 2017

AbstractTeaching socioscientific issues (SSI) necessitates dialogic discourse activities. However, a majority of science teachers prefer monologic discourse in SSI contexts. In addition, some of these teachers are resistant to change (from monologic to dialogic discourse) despite certain professional development attempts. The purpose of the present single‐case study was to investigate the nature of this resistance in a preservice science teacher (PST) (Duygu). We longitudinally followed preservice teachers through 1 year of their continuum of professional development (CPD). We administered a questionnaire including vignettes representing two types of discourse (monologic and dialogic) in SSI teaching; the participants selected one of the vignettes at four different points in their CPD: before an argumentation‐based workshop (N = 122), after the workshop (N = 6), after a SSI‐based teaching practicum (N = 5), and during the induction year (N = 1). The interviews (semi‐structured and stimulated recall) and classroom observations supported these data. We concluded that the argumentation‐based workshop decreased Duygu's resistance to dialogic discourse by producing pseudo‐changes, emergencies, and no changes in her beliefs. However, negative experiences during the teaching practicum enhanced resistance and resulted in a reversal of previous positive beliefs. Similarly, negative induction experiences contributed to her resistance by elaborating previous negative beliefs. In addition, we argue that resistance to change is a complex process exceeding the boundaries of units (e.g., discourse), subjects (e.g., SSI), and subject‐matter education (e.g., science education). The cognitive mechanisms (epistemic heuristic, evidence‐based justification, and prioritization), belief development processes (pseudo‐change, reversal, etc.), and a range of barriers (limited educational opportunities, naïve epistemologies, an argumentation‐avoider personality, etc.) produce a complex ecosystem. We believe that any effort that would be conducted to change science teachers’ teaching orientations from monologic to more dialogic versions and that does not consider this ecosystem will not thrive. © 2017 Wiley Periodicals, Inc. J Res Sci Teach 54:764–789, 2017
Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus
Authors: Bloom Kaitlyn , Mohsen Al‐Walid , Karunanidhi Anuradha , El Demellawy Dina , Reyes‐Múgica Miguel , Wang Yudong , Ghaloul‐Gonzalez Lina , Otsubo Chikara , Tobita Kimi , Muzumdar Radhika , Gong Zhenwei , Tas Emir , Basu Shrabani , Chen Jie , Bennett Michael , Hoppel Charles , Vockley Jerry 
Published: January 2017

AbstractThe Native American Pima population has the highest incidence of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) of any reported population, but the pathophysiologic mechanism is unknown. Genetic studies in Pima Indians have linked acyl‐CoA dehydrogenase 10 (ACAD10) gene polymorphisms, among others, to this predisposition. The gene codes for a protein with a C‐terminus region that is structurally similar to members of a family of flavoenzymes—the acyl‐CoA dehydrogenases (ACADs)—that catalyze α,β‐dehydrogenation reactions, including the first step in mitochondrial FAO (FAO), and intermediary reactions in amino acids catabolism. Dysregulation of FAO and an increase in plasma acylcarnitines are recognized as important in the pathophysiology of IR and T2DM. To investigate the deficiency of ACAD10 as a monogenic risk factor for T2DM in human, an Acad‐deficient mouse was generated and characterized. The deficient mice exhibit an abnormal glucose tolerance test and elevated insulin levels. Blood acylcarnitine analysis shows an increase in long‐chain species in the older mice. Nonspecific variable pattern of elevated short‐terminal branch‐chain acylcarnitines in a variety of tissues was also observed. Acad10 mice accumulate excess abdominal adipose tissue, develop an early inflammatory liver process, exhibit fasting rhabdomyolysis, and have abnormal skeletal muscle mitochondria. Our results identify Acad10 as a genetic determinant of T2DM in mice and provide a model to further investigate genetic determinants for insulin resistance in humans.
Personalisierte Medizin: Strukturen, Tumorboards, Visionen
Authors: Heining Christoph , Horak Peter , Gröschel Stefan , Glimm Hanno , Fröhling Stefan 
Published: January 2017

Zusammenfassung
Die zunehmende Berücksichtigung molekularer Charakteristika in der Therapieauswahl hat bei etlichen histologisch nicht weiter zu differenzierenden Tumorentitäten zu einer relevanten Prognoseverbesserung geführt. Beispiele wie das EGFR-mutierte Bronchialkarzinom oder das BRAF-mutierte maligne Melanom, die effektiv durch Kinaseinhibitoren behandelt werden können, ebenso wie neue Einblicke in genetische Determinanten des Ansprechens auf eine Immuncheckpointblockade lassen darauf hoffen, dass diese Ansätze auch bei anderen Tumorentitäten, Proteinfamilien und Medikamentenklassen Anwendung finden werden. Moderne Hochdurchsatzverfahren zur Sequenzierung von DNA und RNA können detaillierte Informationen über alle somatischen Alterationen in Krebsgenomen liefern und werden zunehmend bezahlbar. Die Integration dieser Analytik in klinische Abläufe stellt aber eine große Herausforderung dar. Innerhalb des NCT MASTER-Programms wurde ein standardisierter Arbeitsablauf etabliert, der ein interdisziplinäres Molekulares Tumorboard beinhaltet und eine umfassende Tumorgenomsequenzierung im klinischen Kontext ermöglicht. Im Rahmen molekular stratifizierter Studienkonzepte gilt es nun, die Umsetzung individueller Therapieempfehlungen und die Evaluation der Therapieresultate zu optimieren.
Personalisierte Medizin in der Hämatologie am Beispiel der akuten myeloischen Leukämie
Authors: Rücker Frank G. , Bullinger Lars 
Published: January 2017

Zusammenfassung
Fortschritte in der genetischen Charakterisierung von Leukämien und Lymphomen haben in den letzten Jahren zielgerichtete Therapieansätze ermöglicht. So haben zum Beispiel BCR-ABL1-inhibierende Tyrosinkinaseinhibitoren (TKI) die Behandlung der chronischen myeloischen Leukämie (CML) revolutioniert. Im Gegensatz dazu hat sich die Behandlung der akuten myeloischen Leukämie (AML) in den letzten 40 Jahren nicht wesentlich verändert, wobei neueste Erkenntnisse beginnen, auch zielgerichtete Therapien in der AML zu ermöglichen. Als sehr heterogene Erkrankung mit unterschiedlichem Ausgang, je nach AML-Subtyp, haben jüngste Fortschritte im Verständnis der AML-Biologie und der Identifizierung von Treibermutationen eine neue Ära der molekularen Therapie ermöglicht. Eine Reihe von prognostischen und prädiktiven molekularen Markern und Signalwegen wurden als neue therapeutische Ziele entdeckt, wie z. B. die Aktivierung der Fms-like-tyrosinkinase-3(FLT3)-Rezeptortyrosinkinase oder aberrante DNA-Methylierungsmuster, denen eine Vielzahl unterschiedlicher Mutationen in epigenetischen Treibern zugrunde liegt. Aber auch zielgerichtete Therapien mit monoklonalen Antikörpern und weiteren Kinaseinhibitoren sind vielversprechende Therapieoptionen, die dazu beitragen könnten, die Heilungsrate der AML weiter verbessern zu können. In diesem Übersichtsartikel werden wir die aktuellen Ansätze zielgerichteter Therapien bei der AML beleuchten und einen Ausblick auf neuartige und bevorstehende therapeutische Optionen sowie einen kurzen Überblick zu den aktuellen Optionen bei weiteren hämatologischen Neoplasien geben.
Methods for 20S Immunoproteasome and 20S Constitutive Proteasome Determination Based on SPRI Biosensors
Authors: Anna Sankiewicz , Agnieszka Markowska , Zenon Lukaszewski , Beata Puzan , Ewa Gorodkiewicz 
Published: January 2017

Abstract
The 20S proteasome, released into the circulation, is a novel cancer biomarker. It exists in two forms: the constitutive proteasome (20Sc) and the immunoproteasome (20Si), which both have separate diagnostic significance. The aim of this work was to develop new methods for 20Si and 20Sc determination. Five alternative specific biosensors usable with the surface plasmon resonance imaging (SPRI) technique for 20Si determination have been developed. Specific 20Si entrapment on the biosensor surface from an analyzed solution was achieved by means of an immobilized specific 20Si receptor. Four of the biosensors contain newly synthesized specific 20Si receptors, while the fifth contains the inhibitor ONX 0914. A method for 20Sc determination using an SPRI biosensor containing PSI inhibitor has been developed. By the introduction of an inhibitor blocking 20Si, 20Sc is selectively determined. All of the methods developed for 20Si and 20Sc determination exhibit good selectivity and satisfactory precision, recoveries and dynamic response ranges. 20Si and 20Sc were determined in blood plasma samples from healthy donors and patients with acute leukemia. In the case of these patients 20Si was the major component, and its level was more than one order of magnitude higher than in the healthy donors.
Controlled Source Audio Magneto Telluric (CSAMT) Studies for Uranium Exploration in Durgi Area, Palnad Sub-basin, Cuddapah Basin, India
Authors: Kumar Indresh , Kumar S. Vijaya , Babu V. Ramesh , Kumar B. V. L. , Dash J. K. , Chaturvedi A. K. 
Published: January 2017

ABSTRACT
Cuddapah basin is known for hosting unconformity proximal uranium deposits viz., Lambapur, Peddagattu, Chitirial and Koppunuru along the northern margin of the basin. It is well known that these deposits are mostly associated with basement granitoids in Srisailam Sub-basin, and with cover sediments in Palnad sub-basin where basement topography and fault/fracture system influence the fluid flow causing basement alteration and ore deposition. Geological setup, surface manifestation of uranium anomalies and association of the hydro-uranium anomalies near Durgi area in southern part of the Palnad sub-basin, have prompted detail investigation by geophysical methods to probe greater depths. Controlled Source Audio Magneto Telluric (CSAMT) survey conducted over five decades of frequency (0.1-9600 Hz) delineated the various lithounits of Kurnool and Nallamalai Groups along with their thicknesses as there exist an appreciable resistivity contrast. Interpretation of CSAMT sounding data are constrained by resistivity logs and litholog data obtained from the boreholes drilled within the basin indicated three to four layered structure. Sub-surface 2-D and 3-D geo-electrical models are simulated by stitching 1-D layered inverted resistivity earth models. Stitched 1-D inverted resistivity sections revealed the unconformity between the Kurnool Group and Nallamalai Group along with basement undulations. The faults/fractures delineated from the CSAMT data corroborated well with the results of gravity data acquired over the same area. Simulated 3-D voxel resistivity model helped in visualising the faults/fractures, their depth extent, thickness of the Banganapalle quartzite and basement configuration. Integrated interpretation of CSAMT, gravity and borehole data facilitated in delineating the unconformity and the structural features favourable for uranium mineralisation in deeper parts of the Palnad sub-basin.
Geochemistry of Vellayani Lake Sediments: Indicators of Weathering and Provenance
Authors: Nair Veena , Achyuthan Hema 
Published: January 2017

ABSTRACT
The Vellayani lake, located on the west coast, Kerala, South India, is a natural fresh water lake. In order to understand the source and nature of the sediments; thirteen lake floor sediment samples were collected from the Vellayani lake at different intervals along the S-N transects covering the entire surface area of the lake. Textural studies indicate that lake floor sediments are dominant in sand (55.39%) followed by clay (30.57%) and silt (14.04%) fractions. Coarse components are dominant at the inlet ofthe stream into the lake. The geochemical content of the sediments reveals low SiO2, MnO, CaO, MgO, Na2O, K2O, and P2O5 content while TiO2, Fe2O3 and Al2O3 are high when compared with Post Archean Australian Shale (PAAS) and Upper Continental Crust (UCC) values. SiO2 is high in coarse fractions while Al2O3 is strongly associated with fine sediments. Major oxide contents supported by Rare Earth Element (REE) data reveal a distinct negative Eu anomaly reflecting a dominant cratonic origin of the sediments. Detailed geochemical data indicate a mixed source, predominantly, the lateritic soils, sedimentary and metamorphic bedrocks exposed around the lake and in the catchment area.
Error in Digital Network and Basin Area Delineation using D8 Method: A Case Study in a Sub-basin of the Ganga
Authors: Kumar Brijesh , Patra Kanhu Charan , Lakshmi Venkat 
Published: January 2017

ABSTRACT
Digital elevation model (DEM) is one of the input data derived from different satellite sensors for hydrologic and hydraulic modelings. Two prime questions could be answered before using these DEMs. First, the acceptability of datasets for our use and second appropriate resolution of the dataset. Three widely used DEMs SRTM 30m, ASTER 30m and SRTM 90m are analyzed to evaluate their suitability to delineate river network and basin boundary area. The hydrology tool of spatial analyst extension inbuilt in ArcGIS 10.2 (which uses the D8 method for calculation of flow direction) has been used for the delineation of both river networks and basin boundary. The assessment of river network alignment and boundary delineation is carried out in the seven sub-catchments of Gandak river basin having different morphological characteristics. The automatically delineated boundary area for all the three DEMs reflects a significant difference when compared with the digitized basin area from the Ganga flood control commission (GFCC) map. The maximum boundary area delineation error is 39137.20 km2 for ASTER 30m, and minimum delineation error of 13239.28 km2 for SRTM 90m. In the stream network, delineation accuracy is good for SRTM 90m while, except Gandak trunk, ASTER 30m DEM shows better delineation accuracy indicated by mean absolute error (MAE) and standard deviation (SD).