bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depressive symptoms in adolescence: The role of perceived parental support, psychological control, and proactive control in interaction with 5-HTTLPR
Authors: Van Assche E. , Moons T. , Van Leeuwen K. , Colpin H. , Verschueren K. , Van Den Noortgate W. , Goossens L. , Claes S. 
Published: April 2016

AbstractBackgroundParenting dimensions are associated with depressive symptoms in adolescents. We investigated the role of perceived parenting dimensions and gene-environment interactions between these perceived parenting dimensions and five well-known variable number of tandem repeats (VNTRs): 5-HTTLPR, STin2, DAT1, DRD4, and MAO-A, in depressive symptoms.MethodsFrom a non-clinical sample of 1111 Belgian adolescents (mean age: 13.79 years, SD = .94; 51% boys), 1103 adolescents consented for genetic research. Five VNTRs were analyzed using DNA from saliva samples. Perceived parenting dimensions (i.e., support, proactive control, psychological control, punishment, and harsh punishment) were examined using self-report scales completed by adolescents and their parents. Depressive symptoms were investigated using the CES-D self-report scale. Statistical analyses were performed in R using linear regression.ResultsParental support, as perceived by the adolescent, was negatively associated with depressive symptoms (CES-D) and psychological control was positively associated with these symptoms. The only interaction effect withstanding correction for multiple testing was observed for 5-HTTLPR and the difference in proactive control as perceived by adolescents in comparison to parents. Short-allele carriers showed more depressive symptoms when there was a higher discrepancy in proactive control as perceived by adolescents versus parents.ConclusionsOur results suggest that perceived parenting dimensions are associated with depressive symptoms, as measured by the CES-D. We only found modest evidence for 5-HTTLPR as a moderator in the association between the difference in perception of proactive control (adolescents vs. parents) and depressive symptoms.
Political Connections, Home Formal Institutions, and Internationalization: Evidence from China
Authors: Du Xingqiang , Luo Jin-hui 
Published: April 2016

ABSTRACTThis study draws on the resource dependence theory and institution-based view to examine political connections in the home market and home formal institutions for their impact on the internationalization of emerging market firms in the context of China. The results suggest that political connections at home may prevent emerging market firms from implementing internationalization strategies by reducing the dependence constraints imposed by local governments and foreign firms, whereas home formal institutional development may promote the strategy transition of emerging market firms from building political connections to international expansion and also reduce the negative impact of political connections. Overall, our findings indicate that political connections and formal institutions at home play an important role in shaping emerging market firms’ strategies of outward internationalization.
Labor Unrest and Incipient Collective Bargaining in China
Authors: Kuruvilla Sarosh , Zhang Hao 
Published: April 2016

ABSTRACTIn this paper, we argue that both labor unrest and collective bargaining are increasing in China. Using McAdam's political process theory, we argue that Chinese workers are striking more and offensively in support of their economic demands. We identify the state's interests in promoting collective bargaining, and through an analysis of union and employers’ organizations, attempt to predict the future trajectory of collective bargaining in China. Using new data about strikes, we confirm our argument that strikes in China are increasing. Based on very limited past and current research, we create a taxonomy of baseline collective bargaining in China against which future developments can be compared.
Detection of a weak late-stage deformation event in granitic gneiss through anisotropy of magnetic susceptibility: implications for tectonic evolution of the Bomdila Gneiss in the Arunachal Lesser Himalaya, Northeast India
Authors: SINGH R. K. BIKRAMADITYA , SINGH A. KRISHNAKANTA , SEN KOUSHIK , SANGODE S. J. 
Published: April 2016

AbstractOutcrop-scale structures and magnetic fabric anisotropy of the Bomdila Gneiss (BG) that intruded the Lesser Himalayan Crystallines (LHC) of the Arunachal Lesser Himalaya are studied to understand the BG deformation history and tectonic evolution. Detailed analysis of structures reveals that the LHC have undergone three phases of deformation, D1, D2and D3. The S2foliation developed during the second phase of deformation (D2) is the most penetrative planar fabric in the studied rock, which shows a general ENE–WSW strike with moderate NW dip. Mesoscopic evidence of a later phase of deformation (D3) in the BG is lacking. Evidence of D3deformation in the form of F3folds is only observed in the adjacent metasedimentary rocks of the LHC. The magnetic foliations recorded from anisotropy of magnetic susceptibility (AMS) analysis of the BG are mostly striking NW–SE with a moderate dip towards the NE or SW, and magnetic lineation is mostly sub-horizontal and dominantly plunging towards the SE. Our study shows that the magnetic fabric of the BG does not correspond to any visible outcrop-scale mesoscale foliation. However, the magnetic foliation of the BG is parallel to the axial plane of the F3folds of the adjacent metasedimentary rocks of the LHC. Integration of AMS and outcrop-scale structural analysis helps us envisage the superposed deformation history of the BG. Our study emphasizes the importance of AMS to detect late-stage or feeble deformation events that leave no visible outcrop-scale imprint and are difficult to discern through conventional geological means.
Do Demographics and Functional Abilities Influence Vehicle Type Driven by Older Canadians?
Authors: Vrkljan Brenda , Crizzle Alexander , Villeneuve Simon , Porter Michelle , Koppel Sjaan , Mazer Barbara L. , Naglie Gary , Bédard Michel , Tuokko Holly A. , Gélinas Isabelle , Marshall Shawn C. , Rapoport Mark J. 
Published: April 2016

RÉSUMÉDans cette étude, nous avons examiné les données de base Candrive (n = 928; âge de 70 à 94; 62% étaient des hommes) pour analyser si les caractéristiques des conducteurs (âge, sexe, taille, poids, IMC) et certaines capacités fonctionnelles (c’est-à-dire, le test de rythme rapide à pied, le test “Up and Go”) ont influencé les types de véhicules conduits. Il y avait des différences significatives en ce qui concerne le type de véhicule et l’âge du conducteur (F = 3,58, p = 0,003), la taille (F = 13,32, p <0,001), le poids (F = 14,31, p <0,001) , et l’IMC (F = 4,40, p = 0,001). Une plus grande proportion de conducteurs qui souffrait d’ostéoporose (χ2 = 21,23, p = 0,020) et ostéo / polyarthrite rhumatoïde (χ2 = 21,23, p = 0,020) conduisait des voitures de petite ou moyenne taille par rapport aux plus grandes tailles. D’autres recherches sont nécessaires pour examiner l’interaction des conducteurs âgés avec leurs véhicules, et la relation à la démographie et aux capacités fonctionnelles, compte tenu de la vulnérabilité de ce groupe d’âge à des blessures automobiles.
Implicit Spoken Words and Motor Sequences Learning Are Impaired in Children with Specific Language Impairment
Authors: Desmottes Lise , Meulemans Thierry , Maillart Christelle 
Published: April 2016

AbstractObjectives: This study aims to compare verbal and motor implicit sequence learning abilities in children with and without specific language impairment (SLI). Methods: Forty-eight children (24 control and 24 SLI) were administered the Serial Search Task (SST), which enables the simultaneous assessment of implicit spoken words and visuomotor sequences learning. Results: Results showed that control children implicitly learned both the spoken words as well as the motor sequences. In contrast, children with SLI showed deficits in both types of learning. Moreover, correlational analyses revealed that SST performance was linked with grammatical abilities in control children but with lexical abilities in children with SLI. Conclusions: Overall, this pattern of results supports the procedural deficit hypothesis and suggests that domain general implicit sequence learning is impaired in SLI. (JINS, 2016, 22, 1–10)
EMBRACING THE TECHNICALITIES: EXPRESSIVE COMPLETENESS AND REVENGE
Authors: TOURVILLE NICHOLAS , COOK ROY T 
Published: April 2016

AbstractThe Revenge Problem threatens every approach to the semantic paradoxes that proceeds by introducing nonclassical semantic values. Given any such collection Δ of additional semantic values, one can construct a Revenge sentence:This sentence is either false or has a value in Δ.TheEmbracing Revengeview, developed independently by Roy T. Cook and Phlippe Schlenker, addresses this problem by suggesting that the class of nonclassical semantic values is indefinitely extensible, with each successive Revenge sentence introducing a new ‘pathological’ semantic value into the discourse. The view is explicitly motivated in terms of the idea that every notion thatseemsto be expressible (e.g., “has a value in Δ”, for any definite collection of semantic values Δ) should, if at all possible,beexpressible. Extant work on the Embracing Revenge view has failed to live up to this promise, since the formal languages developed within such work are expressively impoverished. We rectify this here by developing a much richer formal language, and semantics for that language, and we then prove an extremely powerful expressive completeness result for the system in question.
Alltagswirksamkeit kognitiver Verhaltenstherapie bei Kindern und Jugendlichen mit Zwangsstörungen in einer Ausbildungsambulanz
Authors: Beig Inga , Döpfner Manfred , Goletz Hildegard , Plück Julia , Dachs Lydia , Kinnen Claudia , Walter Daniel 
Published: April 2016

Zusammenfassung. Hintergrund: Zur Behandlung von Zwangsstörungen im Kindes- und Jugendalter gilt die kognitive Verhaltenstherapie (KVT) als Therapiemethode erster Wahl, doch bisher wurde hauptsächlich die Wirksamkeit von streng manualisierter KVT im Rahmen von randomisiert-kontrollierten Studien untersucht. Studien zur Wirksamkeit von Routinetherapien gibt es kaum. Methode: Um die Alltagswirksamkeit von KVT zu überprüfen, wurden über neun Jahre erfasste Daten zu Behandlungsverläufen in einer universitären Ausbildungsambulanz ausgewertet. Für n = 53 Patienten, deren Elternbeurteilungsbögen vorlagen, und n = 53 Patienten, deren Selbstbeurteilungsbögen vorlagen, wurden Prä-Post-Analysen durchgeführt. Ergebnisse: Im Verlauf der Therapie konnten signifikante Reduktionen der Zwangssymptomatik mit hohen Prä-Post-Effektstärken (Cohens d) im Elternurteil (d = 0.91) und im Selbsturteil (d = 0.88) sowie der komorbiden Symptomatik mit mittleren bis hohen Effektstärken auf der Gesamtskalenebene im Elternurteil (d = 0.55 bis d = 0.87) und im Selbsturteil (d = 0.46 bis d = 0.74) gefunden werden. Bei 46.3 % bis 59.4 % der Patienten wurde eine klinisch signifikante Verbesserung mit unauffälliger Zwangssymptomatik zum Posttestzeitpunkt erzielt. Bei zwischen 22.5 % und 45.5 % der Patienten (Elternurteil) bzw. 32.0 % und 81.8 % (Selbsturteil) wurde dies auch hinsichtlich der komorbiden Symptomatik erreicht. Schlussfolgerungen: Im Verlauf einer KVT zur Behandlung von juvenilen Zwangsstörungen in einer universitären Ausbildungsambulanz lassen sich deutliche Verminderungen der Zwangs- und komorbiden Symptomatik nachweisen. Diese Ergebnisse sind ein Hinweis darauf, dass kognitiv-verhaltenstherapeutische Routinetherapien eine wirksame Methode zur Behandlung von juvenilen Zwangsstörungen darstellen. Schlüsselwörter: kognitive Verhaltenstherapie, Kinder und Jugendliche, Zwangsstörung, komorbide Störungen, Alltagswirksamkeit; Routinetherapie
Phase-selective graphene oxide membranes for advanced microfluidic flow control
Authors: Gaughran Jennifer , Boyle David , Murphy James , Kelly Robert , Ducrée Jens 
Published: April 2016

AbstractFor the first time, we harness the unique phase-selectivity of chip-integrated graphene oxide (GO) membranes to significantly enhance flow control on centrifugal microfluidic platforms. In this paper, we present novel processes for the assembly of these GO membranes into polymeric microfluidic systems and demonstrate that multilayer GO membranes allow the passage of water while blocking pressurized air and organic solutions.
Global gene expression profiling of JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts
Authors: Hu Yu-Jie , Imbalzano Anthony N. 
Published: April 2016

AbstractEmerging evidence suggests Jumonji domain-containing proteins are epigenetic regulators in diverse biological processes including cellular differentiation and proliferation. RNA interference-based analyses combined with gene expression profiling can effectively characterize the cellular functions of these enzymes. We found that the depletion of Jumonji domain-containing protein 6 (JMJD6) and its paralog protein Jumonji domain-containing protein 4 (JMJD4) individually by small hairpin RNAs (shRNAs) slowed cell proliferation of mouse NIH3T3 fibroblasts. We subsequently performed gene expression profiling on both JMJD6- and JMJD4-depleted mouse NIH3T3 fibroblasts using the Affymetrix GeneChip Mouse Exon 1.0 ST Array. Here we report the gene profiling datasets along with the experimental procedures. The information can be used to further investigate how JMJD6 and JMJD4 affect gene expression and cellular physiology.
TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells
Authors: Ren Yonggang , Qiu Lu , Lü Fenglin , Ru Xufang , Li Shaojun , Xiang Yuancai , Yu Siwang , Zhang Yiguo 
Published: April 2016

AbstractThe full-length Nrf1α is processed into distinct isoforms, which together regulate genes essential for maintaining cellular homeostasis and organ integrity and liver-specific loss of Nrf1 in mice results in spontaneous hepatoma. Herein, we report that the human constitutive Nrf1α, rather than smaller Nrf1β/γ, expression is attenuated or abolished in the case of low-differentiated high-metastatic hepatocellular carcinomas. Therefore, Nrf1α is of importance in the physio-pathological origin and development, but its specific pathobiological function(s) remains elusive. To address this, TALENs-directed knockout of Nrf1α, but not Nrf1β/γ, is created in the human hepatocellular carcinoma (HepG2) cells. The resulting Nrf1α−/− cells are elongated, with slender spindle-shapes and enlarged gaps between cells observed under scanning electron microscope. When compared with wild-type controls, the invasive and migratory abilities of Nrf1α−/− cells are increased significantly, along with the cell-cycle G2-M arrest and S-phase reduction, as accompanied by suppressed apoptosis. Despite a modest increase in the soft-agar colony formation of Nrf1α−/− cells, its loss-of-function markedly promotes malgrowth of the subcutaneous carcinoma xenograft in nude mice with hepatic metastasis. Together with molecular expression results, we thus suppose requirement of Nrf1α (and major derivates) for gene regulatory mechanisms repressing cancer cell process (e.g. EMT) and malignant behaviour (e.g. migration).
Achieving High Performance in AC-Field Driven Organic Light Sources
Authors: Xu Junwei , Carroll David L. , Smith Gregory M. , Dun Chaochao , Cui Yue 
Published: April 2016

AbstractCharge balance in organic light emitting structures is essential to simultaneously achieving high brightness and high efficiency. In DC-driven organic light emitting devices (OLEDs), this is relatively straight forward. However, in the newly emerging, capacitive, field-activated AC-driven organic devices, charge balance can be a challenge. In this work we introduce the concept of gating the compensation charge in AC-driven organic devices and demonstrate that this can result in exceptional increases in device performance. To do this we replace the insulator layer in a typical field-activated organic light emitting device with a nanostructured, wide band gap semiconductor layer. This layer acts as a gate between the emitter layer and the voltage contact. Time resolved device characterization shows that, at high-frequencies (over 40 kHz), the semiconductor layer allows for charge accumulation in the forward bias, light generating part of the AC cycle and charge compensation in the negative, quiescent part of the AC cycle. Such gated AC organic devices can achieve a non-output coupled luminance of 25,900 cd/m2 with power efficiencies that exceed both the insulator-based AC devices and OLEDs using the same emitters. This work clearly demonstrates that by realizing balanced management of charge, AC-driven organic light emitting devices may well be able to rival today’s OLEDs in performance.
IEX-1 deficiency induces browning of white adipose tissue and resists diet-induced obesity
Authors: Shahid Mohd , Javed Ammar A. , Chandra David , Ramsey Haley E. , Shah Dilip , Khan Mohammed F. , Zhao Liping , Wu Mei X. 
Published: April 2016

AbstractChronic inflammation plays a crucial role in the pathogenesis of obesity and insulin resistance. However, the primary mediators that affect energy homeostasis remain ill defined. Here, we report an unexpected role for immediate early response gene X-1 (IEX-1), a downstream target of NF-κB, in energy metabolism. We found that IEX-1 expression was highly induced in white adipose tissue (WAT) in both epidydmal and subcutaneous depots but not in interscapular brown adipose tissue (BAT) in mice fed a high fat diet (HFD). Null mutation of IEX-1 protected mice against HFD-induced adipose and hepatic inflammation, hepatic steatosis and insulin resistance. Unexpectedly, IEX-1 knockout (IEX-1−/−) mice gained markedly less weight on HFD for 20 weeks as compared to wild-type (WT) littermates (37 ± 3 versus 48 ± 2 gm) due to increased energy expenditure. Mechanistically, we showed that IEX-1 deficiency induced browning and activated thermogenic genes program in WAT but not in BAT by promoting alternative activation of adipose macrophages. Consequently, IEX-1−/− mice exhibited enhanced thermogenesis (24 ± 0.1 versus 22 ± 0.1 kcal/hour/kg in WT mice) explaining increased energy expenditure and lean phenotype in these mice. In conclusion, the present study suggests that IEX-1 is a novel physiological regulator of energy homeostasis via its action in WAT.
Molecular Recognition of Biomolecules by Chiral CdSe Quantum Dots
Authors: Mukhina Maria V. , Korsakov Ivan V. , Maslov Vladimir G. , Purcell-Milton Finn , Govan Joseph , Baranov Alexander V. , Fedorov Anatoly V. , Gun’ko Yurii K. 
Published: April 2016

AbstractMolecular recognition is one of the most important phenomena in Chemistry and Biology. Here we present a new way of enantiomeric molecular recognition using intrinsically chiral semiconductor nanocrystals as assays. Real-time confocal microscopy studies supported by circular dichroism spectroscopy data and theoretical modelling indicate an ability of left-handed molecules of cysteine and, to a smaller extent, histidine and arginine to discriminate between surfaces of left- and right-handed nanocrystals.
Population Dynamics of Bulking and Foaming Bacteria in a Full-scale Wastewater Treatment Plant over Five Years
Authors: Jiang Xiao-Tao , Guo Feng , Zhang Tong 
Published: April 2016

AbstractBulking and foaming are two notorious problems in activated sludge wastewater treatment plants (WWTPs), which are mainly associated with the excessive growth of bulking and foaming bacteria (BFB). However, studies on affecting factors of BFB in full-scale WWTPs are still limited. In this study, data sets of high-throughput sequencing (HTS) of 16S V3–V4 amplicons of 58 monthly activated sludge samples from a municipal WWTP was re-analyzed to investigate the BFB dynamics and further to study the determinative factors. The population of BFB occupied 0.6~36% (averagely 8.5% ± 7.3%) of the total bacteria and showed seasonal variations with higher abundance in winter-spring than summer-autumn. Pair-wise correlation analysis and canonical correlation analysis (CCA) showed that Gordonia sp. was positively correlated with NO2-N and negatively correlated with NO3-N and Nostocodia limicola II Tetraspharea sp. was negatively correlated with temperature and positively correlated with NH3-N in activated sludge. Bacteria species correlated with BFB could be clustered into two negatively related modules. Moreover, with intensive time series sampling, the dominant BFB could be accurately modeled with environmental interaction network, i.e. environmental parameters and biotic interactions between BFB and related bacteria, indicating that abiotic and biotic factors were both crucial to the dynamics of BFB.
Accurate quantification of supercoiled DNA by digital PCR
Authors: Dong Lianhua , Yoo Hee-Bong , Wang Jing , Park Sang-Ryoul 
Published: April 2016

AbstractDigital PCR (dPCR) as an enumeration-based quantification method is capable of quantifying the DNA copy number without the help of standards. However, it can generate false results when the PCR conditions are not optimized. A recent international comparison (CCQM P154) showed that most laboratories significantly underestimated the concentration of supercoiled plasmid DNA by dPCR. Mostly, supercoiled DNAs are linearized before dPCR to avoid such underestimations. The present study was conducted to overcome this problem. In the bilateral comparison, the National Institute of Metrology, China (NIM) optimized and applied dPCR for supercoiled DNA determination, whereas Korea Research Institute of Standards and Science (KRISS) prepared the unknown samples and quantified them by flow cytometry. In this study, several factors like selection of the PCR master mix, the fluorescent label, and the position of the primers were evaluated for quantifying supercoiled DNA by dPCR. This work confirmed that a 16S PCR master mix avoided poor amplification of the supercoiled DNA, whereas HEX labels on dPCR probe resulted in robust amplification curves. Optimizing the dPCR assay based on these two observations resulted in accurate quantification of supercoiled DNA without preanalytical linearization. This result was validated in close agreement (101~113%) with the result from flow cytometry.
Fungal naphtho-γ-pyrones: Potent antibiotics for drug-resistant microbial pathogens
Authors: He Yan , Tian Jun , Chen Xintao , Sun Weiguang , Zhu Hucheng , Li Qin , Lei Liang , Yao Guangmin , Xue Yongbo , Wang Jianping , Li Hua , Zhang Yonghui 
Published: April 2016

AbstractFour naphtho-γ-pyrones (fonsecinones A and C and aurasperones A and E) were identified as potential antibacterial agents againstEscherichia coli, extended-spectrumβ-lactamase (ESBL)-producingE. coli, Pseudomonas aeruginosa, Enterococcus faecalis, and methicillin-resistantStaphylococcus aureus(MRSA) in anin vitroantibacterial screen of 218 fungal metabolites. Fonsecinone A (2) exhibited the most potent antibacterial activity, with minimum inhibitory concentrations (MICs) of 4.26, 17.04, and 4.26 μg/mL against ESBL-producingE. coli, P. aeruginosa, andE. faecalis, respectively. The inhibitory effects of fonsecinones A (2) and C (3) againstE. coliand ESBL-producingE. coliwere comparable to those of amikacin. Molecular docking-based target identification of naphtho-γ-pyrones1–8revealed bacterial enoyl-acyl carrier protein reductase (FabI) as an antibacterial target, which was further validated by FabI affinity and inhibition assays. Fonsecinones A (2) and C (3) and aurasperones A (6) and E (7) bound FabI specifically and produced concentration-dependent inhibition effects. This work is the first report of anti-drug-resistant bacterial activities of naphtho-γ-pyrones1–8and their possible antibacterial mechanism of action and provides an example of the successful application ofin silicomethods for drug target identification and validation and the identification of new lead antibiotic compounds against drug-resistant pathogens.