bluuebunny/crossref_metadata_2025_split huggingface dataset:
Viscosity Characteristics of Ideal Lubricants to Reduce Stress on Intestinal Mucosa During Balloon‐Assisted Enteroscopy
Authors: Yamauchi Katsuma , Hirose Ryohei , Ikegaya Hiroshi , Mukai Hiroki , Miyazaki Hajime , Watanabe Naoto , Yoshida Takuma , Bandou Risa , Inoue Ken , Dohi Osamu , Yoshida Naohisa , Nakaya Takaaki , Itoh Yoshito 
Published: October 2024

AbstractBalloon‐assisted enteroscopy (BAE) is highly invasive and carries a higher risk of complications such as pain and perforation during enteroscope insertion. Applying lubricants to the small intestinal mucosa and reducing the dynamic friction coefficient (DFC) between the small intestinal mucosa and endoscopic shaft (ES) (or overtube (OT)) can minimize the invasiveness of BAE. However, the ideal viscosity characteristics of these lubricants remain unknown. In this study, a model is developed to measure the DFC using human small intestines from forensic autopsies and determine the ideal viscosity of low‐friction lubricants that exhibit a minimal DFC, thus reducing the pressure on the intestinal lining during the procedure. The results reveal that the DFC is strongly correlated to the lubricant's viscosity rather than its chemical composition. Low‐friction lubricants with viscosities within 0.20–0.32 and 0.35–0.58 Pa·s (at shear rates of 10 s−1) for the OT and ES, respectively, can significantly reduce the DFC, yielding optimal results. These findings highlight the role of viscosity in minimizing the friction between the equipment and small intestinal mucosa. The ideal low‐friction lubricants satisfying the aforementioned viscosity ranges can minimize the invasiveness of BAE by decreasing the friction between the equipment and intestinal lining.
Optimization of laser powder bed fusion process parameter for the fabrication of AlSi12 using NSGA‐II and Pareto search algorithm
Authors: Balla S. K. , Konki R. K. , Manjaiah M. , Joshi A. 
Published: October 2024

AbstractAdditive manufacturing, notably laser powder bed fusion (LPBF), excels in producing complex geometries and is widely used in the automotive, aerospace, and naval industries. Laser powder bed fusion enables the creation of components with the required stiffness and strength at a lighter weight than traditional manufacturing methods. Aluminium alloys are particularly promising for laser powder bed fusion in the automotive and aerospace sectors. To enhance the effectiveness of laser powder bed fusion‐produced components, optimized process parameters must be designed for specific materials. This study investigates the influence of processing parameters, scan speed, scan strategy, and hatch space, on the relative density, surface roughness, and microhardness of AlSi12 samples fabricated by laser powder bed fusion. A Taguchi L27 orthogonal array was used to systematically analyze the effects of these parameters. A regression model was developed and evaluated through analysis of variance using signal‐to‐noise (S/N) ratios to identify optimal parameter values. Results indicated that the scan pattern significantly affects relative density, while hatch space impacts surface roughness and microhardness. Optimal solutions were obtained through multi‐objective optimization using the non‐dominated sorting genetic algorithm (NSGA‐II) and Pareto search algorithms. Experimental validation showed average errors of 0.483 % and 0.461 % for NSGA‐II and Pareto search algorithms, respectively.
FAM20C Promotes Papillary Thyroid Cancer Proliferation and Metastasis via Epithelial–Mesenchymal Transition
Authors: Lin Bangyi , Jiang Xuejuan , Bhandari Adheesh , Chen Qi , Pan Yin 
Published: October 2024

ABSTRACTThyroid cancer (TC) is the prevailing malignancy that impacts the endocrine system, accounting for 1% of all recently diagnosed malignancies in humans. The incidence of TC has been continuously increasing, which can be attributed to advancements in clinical diagnostic technology. However, the mechanisms behind the development of TC are still not well understood. TC is classified into four pathological forms: medullary thyroid cancer, papillary thyroid cancer (PTC), follicular thyroid cancer, and poorly differentiated TC. PTC constitutes more than 80% of all TC cases globally. Current research indicates that complex genetic and cellular processes could be responsible for the growth and spread of TC. Next‐generation sequencing (RNA‐seq) of 79 PTC samples and their corresponding normal thyroid tissues was performed to investigate the molecular mechanisms of PTC. An analysis of RNA‐seq data from a local cohort from The Cancer Genome Atlas (TCGA) revealed that, compared with normal tissues, PTC tissues presented elevated FAM20C expression levels. In vitro, the function of FAM20C was validated with small interfering RNA (siRNA). Gene set enrichment analysis (GSEA) revealed the pathways influenced by FAM20C. A western blot experiment was used to investigate protein expression levels associated with epithelial‒mesenchymal transition (EMT). In conclusion, by regulating EMT, FAM20C facilitates PTC cell proliferation and metastasis.
A control theoretic approach to evaluate and inform ecological momentary interventions
Authors: Fechtelpeter Janik , Rauschenberg Christian , Jalalabadi Hamidreza , Boecking Benjamin , van Amelsvoort Therese , Reininghaus Ulrich , Durstewitz Daniel , Koppe Georgia 
Published: October 2024

AbstractObjectivesEcological momentary interventions (EMI) are digital mobile health interventions administered in an individual's daily life to improve mental health by tailoring intervention components to person and context. Experience sampling via ecological momentary assessments (EMA) furthermore provides dynamic contextual information on an individual's mental health state. We propose a personalized data‐driven generic framework to select and evaluate EMI based on EMA.MethodsWe analyze EMA/EMI time‐series from 10 individuals, published in a previous study. The EMA consist of multivariate psychological Likert scales. The EMI are mental health trainings presented on a smartphone. We model EMA as linear dynamical systems (DS) and EMI as perturbations. Using concepts from network control theory, we propose and evaluate three personalized data‐driven intervention delivery strategies. Moreover, we study putative change mechanisms in response to interventions.ResultsWe identify promising intervention delivery strategies that outperform empirical strategies in simulation. We pinpoint interventions with a high positive impact on the network, at low energetic costs. Although mechanisms differ between individuals ‐ demanding personalized solutions ‐ the proposed strategies are generic and applicable to various real‐world settings.ConclusionsCombined with knowledge from mental health experts, DS and control algorithms may provide powerful data‐driven and personalized intervention delivery and evaluation strategies.
Two‐parametric prescan calibration of gradient‐induced sampling errors for rosette MRI
Authors: Latta Peter , Jiřík Radovan , Vitouš Jiří , Macíček Ondřej , Vojtíšek Lubomír , Rektor Ivan , Standara Michal , Křístek Jan , Starčuk Zenon 
Published: October 2024

AbstractPurposeThe aim of this study was to develop a simple, robust, and easy‐to‐use calibration procedure for correcting misalignments in rosette MRI k‐space sampling, with the objective of producing images with minimal artifacts.MethodsQuick automatic calibration scans were proposed for the beginning of the measurement to collect information on the time course of the rosette acquisition trajectory. A two‐parameter model was devised to match the measured time‐varying readout gradient delays and approximate the actual rosette sampling trajectory. The proposed calibration approach was implemented, and performance assessment was conducted on both phantoms and human subjects.ResultsThe fidelity of phantom and in vivo images exhibited significant improvement compared with uncorrected rosette data. The two‐parameter calibration approach also demonstrated enhanced precision and reliability, as evidenced by quantitative relaxometry analyses.ConclusionAdequate correction of data sampling is a crucial step in rosette MRI. The presented experimental results underscore the robustness, ease of implementation, and suitability for routine experimental use of the proposed two‐parameter rosette trajectory calibration approach.
Constitutive description of snow at finite strains by the modified cam‐clay model and an implicit gradient damage formulation
Authors: Moeineddin Ahmad , Platen Jakob , Kaliske Michael 
Published: October 2024

AbstractSnow, characterized as a unique granular and low‐density material, exhibits intricate behavior influenced by the proximity to its melting point and its three‐phase composition. This composition entails a structured ice skeleton surrounded by voids filled with air and spread with liquid water. Mechanically, snow experiences dynamic transformations, including bonding/degradation between its grains, significant inelastic deformations, and a distinct rate sensitivity. Given snow's varied structures and mechanical strengths in natural settings, a comprehensive constitutive model is necessary. Our study introduces a pioneering formulation grounded on the modified Cam‐Clay model, extended to finite strains. This formulation is further enriched by an implicit gradient damage modeling, creating a synergistic blend that offers a detailed representation of snow behavior. The versatility of the framework is emphasized through the careful calibration of damage parameters. Such calibration allows the model to adeptly capture the effects of diverse strain rates, particularly at high magnitudes, highlighting its adaptability in replicating snow's unique mechanical responses across various conditions. Upon calibration against established experimental benchmarks, the model demonstrates a suitable alignment with observed behavior, underscoring its potential as a comprehensive tool for understanding and modeling snow behavior with precision and depth.
Translabyrinthine versus Retrosigmoid Approach for Vestibular Schwannoma: A Systematic Review and An Updated Meta‐Analysis
Authors: Gibbon Frederico L. , Lindner Rafaela J. , Vial Antônio D. M. , da Silva Guilherme G. , Palavani Lucca B. , Semione Gabriel , Worm Paulo V. , Isolan Gustavo R. , da Silva Vagner A. R. , Bento Ricardo F. , Friedman Rick A. , Lavinsky Joel 
Published: October 2024

AbstractObjectiveSeveral approaches can be used in the surgical treatment of vestibular schwannoma (VS), and the best approach remains uncertain in the literature. This systematic review and meta‐analysis aim to compare the translabyrinthine approach (TLA) with the retrosigmoid approach (RSA) for VS in terms of postoperative complications.Data SourcesPubMed, Web of Science, Embase, and Cochrane.Review MethodsThe primary outcome was cerebrospinal fluid (CSF) leak; secondary outcomes were facial nerve dysfunction (FND), length of stay (LOS), and meningitis. Statistical analysis was performed using RStudio 2024.04.1 + 748. Heterogeneity was assessed with I² statistics. We performed sensitivity analysis with subgroup analysis and meta‐regression. Risk of bias was assessed using ROBINS‐I.ResultsOut of 1140 potential articles, 21 met the inclusion criteria. Among the 4572 patients, 2687 and 1885 patients in the TLA and RSA groups, respectively. No significant differences were found in CSF leak (odds ratio [OR] 1.03; 95% confidence interval [CI] 0.81,1.32; P = .794) or meningitis (OR 1.05; 95% CI 0.45, 2.43; P = .73). Meta‐regression showed no association with CSF leak and the number of cases per center or publication year. The TLA is associated with a shorter LOS (MD −1.20; 95% CI −1.39, −1.01; P < .01) and a higher chance of having and HB 4 or lower compared to patients who underwent RSA (OR 0.30; 95% CI 0.10, 0.89; P = .03).ConclusionThere was no difference in the odds of CSF leak or meningitis between the groups. In addition, the TLA has a shorter LOS and a higher chance of a better facial nerve outcome compared to the RSA.
Clinical Applications and Outcomes of the Supraclavicular Osteocutaneous Flap for Head and Neck Reconstruction
Authors: Tanjapatkul Rungkit , Raktasuvarna Nithi , Jirawatnotai Supasid , Voravitvet Tsz Yin , Sriswadpong Papat 
Published: October 2024

AbstractObjectiveThis study evaluates the clinical applications of the supraclavicular osteocutaneous (SOC) flap in complex head and neck reconstruction and its impact on shoulder function following clavicle resection.Study DesignCase series with a planned chart review.SettingSingle‐institution tertiary care center.MethodsWe reviewed patients with complex mandibular and maxillary defects who underwent SOC flap reconstruction from 2016 to 2020. We detailed flap harvesting techniques, patient characteristics, diagnoses, defect sites, bone dimensions, skin paddle size, vascular supply, and donor site management. Complications and outcomes were also documented.ResultsThe study included 7 patients with diverse clinical conditions and diagnoses. Reconstruction techniques varied, leading to different clavicle thicknesses and skin paddle sizes. Two cases had flap necrosis due to infection, and 1 experienced chronic shoulder discomfort following partial‐thickness clavicle flap surgery. Full‐thickness clavicle harvesting resulted in better outcomes and simplified the procedure. Notably, there were no significant long‐term complications affecting shoulder function.ConclusionThe SOC flap is a promising option for complex head and neck reconstruction, adaptable to specific case requirements and providing reliable vascular supply. It offers favorable clinical outcomes both functionally and aesthetically. Full‐thickness clavicle harvesting, with joint preservation, effectively maintains shoulder function.
The Impact of Hydrostatic Pressure on the Structural, Mechanical, Thermal, and Optoelectronic Characteristics of the RbV3Sb5 Kagome Compound: Ab initio Approach
Authors: Mondal Prianka , Islam Md. Raihan , Khanom Mst. Shamima , Ahmed Farid 
Published: October 2024

AbstractWe studied the RbV3Sb5 kagome compound's structural, mechanical, thermal, and optoelectronic properties. Mulliken and Hirshfeld population analysis found ionic and covalent connections in RbV3Sb5. The Born stability criterion shows that pure RbV3Sb5 is mechanically stable. The precise measurement of 3.96 indicates that our sample has higher machinability at 20 GPa. Low anticipated hardness of RbV3Sb5 suggests it can be used as a soft solid lubricant. Hardness ratings rise with pressure, however there are exceptions. Pressure causes large nonmonotonic changes in RbV3Sb5′s anisotropic characteristics. A comparable 20 GPa Zener anisotropic value, RbV3Sb5 has the highest. The structure's projected Debye temperature at 0 GPa is 284.39 K, indicating softness. Dispersion curves with negative frequencies suggest ground state structural dynamical instability. The structure has no negative‐energy phonon branches under 10 GPa stress. From band structure and density of state analysis, the structure behaves metallically under hydrostatic pressure. Also, the structure has maximal ultra‐violet conductivity and absorption. The absorption coefficient, conductivity, and loss function plots show uniform patterns at all pressures. As pressure rises, these graphs’ peaks blue shift.
Cover Image, Volume 33, Issue 9
Authors: Lane Samantha , Lynn Elizabeth , Shakir Saad 
Published: October 2024

The cover image is based on the article Quantitative Measurement of the Direct Public Health Impact of Medicines Withdrawals in Europe: Development of a Modelling Method and Proof‐of‐Concept Study to Estimate the Morbidity and Mortality Prevented by Regulatory Action by Samantha Lane et al., https://doi.org/10.1002/pds.70003. image
Efficacy and tolerance of intravenous methylprednisolone pulses in children with severe bronchopulmonary dysplasia requiring respiratory support
Authors: Reynaud Josseline , Dreyfus Lélia , Coutier Laurianne , Butin Marine , Godbert Isabelle , Baudin Florent , Horvat Côme , Reix Philippe 
Published: October 2024

AbstractObjectivesBronchopulmonary dysplasia (BPD) is a chronic lung disease that affects premature babies and contributes to their morbidity. French BPD guidelines suggest the use of intravenous methylprednisolone pulses (IVMP) for those who require respiratory support (RS) following 36 weeks postmenstrual age (PMA). However, there is scant data on the efficacy and tolerance for this indication. Our objectives were to assess the efficacy and tolerance of IVMP in patients with severe BPD requiring RS.Study and DesignThis retrospective observational study included preterm infants (<32 weeks gestational age) treated by IVMP between January 2016 and March 2021, in a single tertiary care hospital. The primary endpoint was signified by changes in the Pulmonary Severity Score (PSS). Our secondary endpoints were changes in RS and the tolerance of IVMP.ResultsData of 14 children with BPD under RS were reviewed. Their median [IQR] gestational age at birth was (26[26–29.5] weeks). After IVMP administration, the PSS did not improve significantly from baseline day 0 (D0) (0.85[0.55–1.15]) to D7 (0.74 [0.48–1.00]) or Month 1 (1.02 [0.57–1.48]). Three children (21%) experienced a decrease in RS in the following month of IVMP. There was no negative short‐term impact on growth. Five infants presented infectious complications. The development quotient was measured in 5 children at 2 years of age.ConclusionIn our study, IVMP did not improve PSS and it was associated with a high number of infections. Other studies are needed to better define the place of IVMP in these infants.
Pulmonary arteriovenous malformation in children
Authors: Lim A. Y. L. , Ratjen F. 
Published: October 2024

AbstractPulmonary arteriovenous malformations (PAVMs) are rare abnormalities observed mainly in children with hereditary haemorrhagic telangiectasia (HHT). A majority of patients are asymptomatic at the time of detection. However, complications such as hypoxemia, stroke, cerebral abscess and massive hemoptysis can arise if larger PAVMs remain untreated. Larger PAVMs are usually managed successfully with embolization, although reperfusion of PAVMs have been reported post procedure. Early screening for PAVMs is recommended in asymptomatic children with HHT or those at risk for HHT. Longer term surveillance is also essential, to enable timely identification and management of PAVMs.
Demographic Variance in COVID‐19 Vaccine Hesitancy Among Reproductive‐Aged Females During the First Year of the Vaccine Rollout
Authors: Gilani Sonia K. , Butler Leah N. , Shamshuddin Nabiha , Stoskute Monika , Orlando Vanessa , Barry Cecelia , Class Quetzal A. , Ganti Amitha K. 
Published: October 2024

ABSTRACTObjectiveInitial COVID‐19 vaccine trials excluded pregnant individuals, making eventual vaccine recommendations nongeneralizable. After noninferiority was established, the CDC, WHO, and ACOG supported vaccination of this group. However, only 31% of pregnant people accepted vaccination. This study aims to assess COVID‐19 vaccine hesitancy in a diverse cohort of reproductive‐aged females.MethodsWe used a validated WHO vaccine hesitancy survey tool, modified to address the COVID‐19 vaccine specifically. From August to November 2021, people capable of pregnancy aged 18–50 years were recruited from inpatient and outpatient OB/GYN services at a large, urban, academic centre in the Midwestern United States. The responses were collected anonymously and analysed using Kruskal–Wallis H and Mann–Whitney U tests.ResultsFifty‐one of sixty participants partially or fully completed the survey. Black individuals were more vaccine‐hesitant in general than Hispanic and White individuals (H[2] = 11.179, p < 0.01), and they were more hesitant toward the COVID‐19 vaccine specifically (H[2] = 9.396, p < 0.01). Pregnant people were less confident that the COVID‐19 vaccine was safe overall (H[2] = 11.473, p < 0.005) compared to those recently pregnant or not pregnant. Individuals not using contraception reported being significantly less confident in the safety of the COVID‐19 vaccine (U = 96.500, p < 0.05). Individuals who declined the flu vaccine were more likely to be COVID‐19 vaccine‐hesitant (U = 79.500, p < 0.001). Participants' age and occupation were not associated with vaccine hesitancy.ConclusionVaccine hesitancy particularly among some demographic groups highlights the need to study the underlying factors contributing to a lack of confidence in the safety of the COVID‐19 vaccine.SynopsisOur validated survey‐based study found that Black participants capable of pregnancy were the most vaccine‐hesitant, highlighting a missed opportunity to care for these individuals.
A Highly Sensitive and Selective Iron Ion Fluorescent Probe for Water‐Soluble Pillar[5]Arene
Authors: Tian Xia , Han Jianrong , Li Wei , Yuan Wei , Li Yuting , Wang Yupeng , Wang Chengbin , Su Wei , Liu Shouxin 
Published: October 2024

AbstractA novel d‐gluconamide‐functionalized water‐soluble pillar[5]arene (GWP5) was synthesized through a simple synthetic route. GWP5 showed a remarkable aggregation‐induced emission (AIE) with increasing concentration. This feature served as the basis for the construction of an AIE‐based sensor for fluorescence detection of Fe3+ with high sensitivity and selectivity, with a linear relationship between luminescence quenching and Fe3+ concentration observed from 0 to 20 µM, and a limit of detection of 7.84 × 10−9 M. This fluorescent probe could be applied to the detection of Fe3+ ions in real environmental water samples and in serum samples.
Harmonizing QSAR Machine Learning‐Based Models and Docking Approaches for Identifying Novel Histone Deacetylase 2 Inhibitors
Authors: Tung Dao Quang , Dung Do Thi Mai , Cong Nguyen Thanh , Hai Dao Ngoc Nam , Baecker Daniel , Ngo Son Tung , Dung Phan Thi Phuong , Thuan Nguyen Thi , Nam Nguyen Hai , An Nguyen Ngoc 
Published: October 2024

AbstractMachine learning (ML) algorithms have gained widespread application in constructing computational models for predicting the bioactivity and physicochemical properties of numerous compounds, notably HDAC inhibitors. In this work, 2801 unique compounds with confirmed bioassays on HDAC2 were collected and employed to train ML models to virtually screening and possibly design potential inhibitors for HDAC2. A meticulous 3‐step procedure was first proposed to ensure the hits are within the application domain of the screening models. Through virtual screening of 91 million compounds, 59 structures were suggested by the four highest predictability models as potential HDAC2 inhibitors. The bioactivity of these compounds is further confirmed through a validated docking protocol, wherein 57 out of the 59 active hits proposed by the four models exhibited superior affinity with HDAC2 compared to vorinostat, with docking scores ranging from −10.74 to −7.06 kcal/mol. Lead optimization strategies were then implemented on the top‐performing compound from the molecular docking scores, CID 122648337, enhancing its binding affinity and interactions within the HDAC2 active site. This optimization led to the creation of two novel lead compounds, demonstrating higher affinity to HDAC2 than the initial hits. The stability of lead compounds in the active site was confirmed via MD simulations.