bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Body Mass Index (BMI) with Diet, Physical Activity, and Lifestyle among Undergraduate Dental Students in a Private Dental College in Bangladesh
Authors: Rafique Taslima , Molla Golam Morshed , Ahamed Asma 
Published: October 2024

Background: Obesity can lead to severe health problems and elevate the risk of diseases such as hypertension, dyslipidemia and diabetes due to metabolic changes. Undergraduate dental students often struggle to maintain a healthy lifestyle and eating habits due to academic pressures. BMI, a standard obesity measure, is simple to calculate and assess nutritional status, helping to identify and prevent obesity-related diseases in at-risk individuals. Method: A cross-sectional study was performed among 253 students of Sapporo Dental College, a private dental college in Uttara, Dhaka, Bangladesh, to reveal the prevalence of overweight and obesity according to BMI and its association with dietary habits, physical activities, and lifestyles among them. Data was collected using a self-written, anonymous, semi-structured questionnaire using the convenient sampling technique between July 2023 and September 2023. Result: Among the 253 participants, females (n = 190, 75.10%) are more than males (n = 63, 25%). The prevalence of normal weight, underweight, overweight, and obesity among the participants was 132 (37.93%), 31 (8.91%), 56 (16.09%), and 129 (37.07%), respectively, based on BMI. 84% of obese students were taken 1 meal from outside per day (p values < 0.05). 52% obese students did not engage in any form of physical activity on a weekly basis (p value 0.03). 55.5% obese students slept for < 6 hours every night (p-value 0.04). Conclusion: Early modifications of lifestyle improve health. Annual screenings help to prevent obesity. Fitness and diet programs can reduce dental students' chronic disease risk. Study participants are future physicians. Thus, dental students should be physically active and aware of their eating and sleep habits to reduce obesity, which might influence patients' outlooks.
Update Dent. Coll. j: 2024; 14(2):15-20
Evaluating the role of pericoronary adipose tissue on coronary artery disease: insights from CCTA on risk assessment, vascular stenosis, and plaque characteristics
Authors: Wang Jingyue , Zhang Huicong , Wang Zihao , Liu Wenyun , Cao Dianbo , Tong Qian 
Published: October 2024

IntroductionPericoronary adipose tissue (PCAT) plays a significant role in the occurrence and progression of coronary artery disease (CAD). This study investigates the relationship between PCAT and CAD, focusing on the occurrence of the disease, the severity of vascular narrowing, and the characteristics of arterial plaques.MethodsWe analyzed a cohort of 152 individuals with CAD and 55 individuals with non-coronary artery disease (N-CAD). Participants underwent both coronary computed tomography angiography (CCTA) and digital subtraction angiography (DSA). Utilizing United Imaging software for artificial intelligence delineation, we measured the fat attenuation index (FAI) and volume of PCAT in the left anterior descending (LAD), left circumflex (LCX), and right coronary arteries (RCA).ResultsOur findings demonstrate that while CCTA is effective in diagnosing CAD compared to DSA, its diagnostic power for individual coronary arteries remains limited. Further analysis revealed that the FAI of the RCA and the overall PCAT volume independently influenced CAD (OR: 1.057, 95% CI: 1.002 to 1.116; OR: 0.967, 95% CI: 0.936 to 0.999). FAI showed a significant independent effect on RCA stenosis (OR: 1.041, 95% CI: 1.003 to 1.081), while the fat volume of the LAD had a significant independent effect on LAD stenosis (OR: 0.884, 95% CI: 0.809 to 0.965). A higher FAI and a lower fat volume were significantly correlated with more severe vascular stenosis percentages in all three arteries (p &lt; 0.05), except for the fat volume and stenosis of the LCX. Moreover, we found the significant differences in the fat volume of the LCX between different plaque types (H = 8.869, p = 0.012), with calcified plaques consistently exhibiting the lowest fat volume across all three arteries. Finally, the likelihood ratio test confirmed that incorporating the PCAT fat volume parameter of LAD significantly improved the diagnostic ability of CCTA for both CAD (p = 0.01543) and LAD stenosis (p = 0.001585).ConclusionThe quantification of PCAT has potential application value in the comprehensive assessment of CAD. It is recommended that cardiology and radiology departments consider incorporating PCAT into the assessment criteria for patients suspected of having CAD.
Digital vs. conventional instructor-led midwifery training in Benue State, Nigeria: a randomized non-inferiority trial
Authors: Ujoh Fanan , Dzunic-Wachilonga Anja , Noor Rafat , Gusa Victoria , Ape-aii Roseline , Ohene Isaac , Bola Rajan , Christilaw Jan , Hodgins Stephen , Lett Ronald 
Published: October 2024

BackgroundMany health education institutions in African countries such as Nigeria face increasing enrolment of students but lack an adequate number of instructors to train them. If digital learning can be demonstrated effective in augmenting knowledge and skills, this approach could help fill this gap and improve education efficiency. A needs assessment in two Nigerian midwifery schools confirmed that digital learning would be feasible and welcomed. In this study, the Midwifery Active Digitization Empowerment Initiative (MADE-I) program was tested to determine if digital delivery of the Fundamental Interventions, Referral and Safe Transfer (FIRST) course is at least equally effective for training midwifery students compared to conventional small-group delivery.MethodsA non-inferiority randomized controlled trial design was used, enrolling 130 s-year students from 2 midwifery schools in Benue State, Nigeria. Students were randomly assigned into six cohorts. Each cohort received half of the course on a Learning Management Platform on their mobile phones, the other half through standard small-group teaching. Students’ knowledge, thinking, and technical skills were assessed using a pre-test, post-test, Objective Structured Clinical Exam (OSCE), and daily modular quizzes. The data was analyzed using the difference-in-difference method.ResultsThe study revealed that post-intervention student knowledge and thinking skills did not significantly differ between digital learning (75.26%) and small-group learning arms of the trial (75.02%, p = 0.404). Student knowledge improved significantly compared to the pre-test in both groups (by 25.03 points in the digital arm, 26.39, in small-group). Some differences were observed between digital and small-group learning in disaggregated analysis by specific module and midwifery school. Although there was a trend toward small-group learning of technical skills being more effective than digital learning, no significant differences between groups were observed in the post-intervention OSCE. Students in both groups learned equally well regardless of age, gender, and midwifery school entrance exam score.ConclusionDigital learning is as effective as small-group learning, for midwifery trainees, in augmenting knowledge, thinking, and technical skills addressed in the FIRST course, and have lighter human resource requirements, an important consideration especially in LMIC. However, similar assessments would be needed to assess effectiveness for other digitally delivered clinical education programs.
Roles of NR1I3 and NR1H4 polymorphisms in the susceptibility to antituberculosis drug-induced liver injury in China: a case‒control study
Authors: Xu Xiaoyan , Chen Ruina , Lu Lihuan , Cheng Jingru , He Xiaomin , Pan Hongqiu , Zhang Meiling , Yi Honggang , Tang Shaowen 
Published: October 2024

ObjectiveThe pathogenesis of antituberculosis drug-induced liver injury (AT-DILI) remains largely unknown. The current investigation aimed to determine the genetic contribution of the nuclear receptor subfamily 1 Group I member 3 (NR1I3) and nuclear receptor subfamily 1 Group H member 4 (NR1H4) genes to the risk of AT-DILI in the Chinese population.MethodsA 1:4 matched case‒control study was conducted, and five single nucleotide polymorphisms (SNPs) in the NR1I3 and NR1H4 genes were detected and assessed. Utilizing a multivariate conditional logistic regression model, the effects of haplotype and genotype on the risk of AT-DILI were examined. Extended subgroup analysis was carried out based on sex. The distribution of the peak value of serum liver enzymes also compared among different genotypes.Results224 AT-DILI cases and 896 controls were included in this study. No significant difference was observed in genotypes or haplotypes frequencies between AT-DILI cases and controls. However, comparisons of liver function indicators revealed significant differences in the peak values of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and total bilirubin (TBil) among patients with different genotypes of NR1H4 rs56163822 (GG vs. GT vs. TT, 27.1 U/L vs. 26.0 U/L vs. 23.0 U/L, p = 0.020; 34.0 U/L vs. 31.0 U/L vs. 30.6 U/L, p = 0.008; 15.5 μmol/L vs. 15.0 μmol/L vs. 13.7 μmol/L, p = 0.029, respectively), as well as in the peak values of ALT and AST among male patients with different genotypes of NR1H4 rs56163822 (29.0 U/L vs. 26.9 U/L vs. 22.6 U/L, p = 0.002; 34.0 U/L vs. 32.0 U/L vs. 30.5 U/L, p = 0.019, respectively).ConclusionBased on this 1:4 individual-matched case‒control study, the SNP rs56163822 in the NR1H4 gene may be linked to the susceptibility to AT-DILI in Chinese patients receiving anti-TB treatment. Further studies in larger varied populations are needed to validate our findings.
The association between dietary consumption habits and psoriasis: a two-sample Mendelian randomization study
Authors: Minghui Lu , Changyong Gao , Runtian Zhang , Jianhong Li , Lingling Yuan , Xi Chen 
Published: October 2024

BackgroundPsoriasis is a chronic inflammatory skin disease characterized primarily by erythema and scales, having a wide-ranging impact globally. Previous studies have suggested that dietary consumption habits may influence psoriasis. The objective of this study was to determine the causal relationship between dietary consumption habits and psoriasis using the Mendelian Randomization (MR) approach.MethodsSNP data for 29 dietary consumption habits and psoriasis were obtained from the GWAS catalog database and the FinnGen database, respectively. The Mendelian Randomization analysis was performed using R software, with the 29 dietary consumption habits as the exposure factors and psoriasis as the outcome. Three MR analysis methods—Inverse Variance Weighted (IVW), Weighted Median Estimator (WME), and MR-Egger regression—were employed to study the causal relationship between dietary consumption habits and psoriasis.ResultsThe IVW analysis indicated an OR (95%CI) of 0.065 (0.008–0.555), p = 0.012, demonstrating a negative correlation between the consumption of dried fruit and psoriasis.ConclusionAmong the 29 dietary consumption habits analyzed, the intake of dried fruits is a protective factor against psoriasis. Therefore, it is clinically advisable to appropriately increase the intake of dried fruits among patients with psoriasis, serving as a nutritional therapy method in conjunction with pharmacological treatment.
Case report: Acute liver failure during deferasirox therapy and the potential role of pharmacogenetics
Authors: García-Fariña Belén , Rink Lydia , Santarini Virginia , Westkemper Marco , Dohna-Schwake Christian , Möhlendick Birte 
Published: October 2024

Background and aimsA number of case reports have documented the occurrence of acute hepatic and renal toxicity during treatment with deferasirox (DFX). The precise mechanisms underlying these adverse events remain unclear, with the time to toxicity varying considerably between patients—some experiencing it within weeks of treatment initiation, while others after several years. Recent studies have underscored the association of pharmacogenetic variants in genes responsible for the metabolism and clearance of DFX (ABCC2, ABCG2, and UGT1A1) in the development of toxicity. We present the case of an 8-year-old patient with beta thalassemia major who developed acute hepatic failure years after the initiation of DFX therapy. After ruling out the most likely causes, we performed a pharmacogenetic analysis, which suggested a possible link between the patient’s genotype and the development of toxicity.MethodsSanger sequencing was performed for the most extensively studied single nucleotide polymorphisms (SNPs) studied associated with changes in transporter/enzyme function: ABCC2 rs717620 (c.-24C&gt;T), rs2273697 (c.1249G&gt;A), rs8187710 (c.4544G&gt;A), rs369192412 (g.99781071delG); ABCG2 rs2231142 (c.421C&gt;A); UGT1A1 *6 rs4148323 (c.211G&gt;A), *28 rs3064744 (g.233760235TA[8]), *36 rs3064744 (g.233760235TA[6]) and *37 rs3064744 (g.233760235TA[9]).ResultsThe patient is heterozygous for two ABCC2 variants, namely rs717620 (c.-24C&gt;T) and rs2273697 (c.1249G&gt;A). These variants have the potential to cause a reduction in transporter function, which could in turn result in decreased drug clearance and increased toxicity.DiscussionThe precise mechanism by which toxicity developed in this case remains unclear and is likely multifactorial. However, it is probable that the presence of SNPs in the gene ABCC2 played a substantial role. Our findings align with those of previously published reports of remarkably similar cases, where patients also exhibited genetic variants in the gene ABCC2.
De novo design of mIDH1 inhibitors by integrating deep learning and molecular modeling
Authors: Sun Dingkang , Xu Lulu , Tong Mengfan , Wei Zhao , Zhang Weitong , Liang Jialong , Liu Xueying , Wang Yuwei 
Published: October 2024

BackgroundMutations in the IDH1 gene have been shown to be an important driver in the development of acute myeloid leukemia, gliomas and certain solid tumors, which is a promising target for cancer therapy.MethodsBidirectional recurrent neural network (BRNN) and scaffold hopping methods were used to generate new compounds, which were evaluated by principal components analysis, quantitative estimate of drug-likeness, synthetic accessibility analysis and molecular docking. ADME prediction, molecular docking and molecular dynamics simulations were used to screen candidate compounds and assess their binding affinity and binding stability with mutant IDH1 (mIDH1).ResultsBRNN and scaffold hopping methods generated 3890 and 3680 new compounds, respectively. The molecules generated by the BRNN performed better in terms of molecular diversity, druggability, synthetic accessibility and docking score. From the 3890 compounds generated by the BRNN model, 10 structurally diverse drug candidates with great docking score were preserved. Molecular dynamics simulations showed that the RMSD of the four systems, M1, M2, M3 and M6, remained stable, with local flexibility and compactness similar to the positive drug. The binding free energy results indicated that compound M1 exhibited the best binding properties in all energy aspects and was the best candidate molecule among the 10 compounds.ConclusionIn present study, compounds M1, M2, M3 and M6 generated by BRNN exhibited optimal binding properties. This study is the first attempt to use deep learning to design mIDH1 inhibitors, which provides theoretical guidance for the design of mIDH1 inhibitors.
Could an evaluative conditioning intervention ameliorate paranoid beliefs? Self-reported and neurophysiological evidence from a brief intervention focused on improving self-esteem
Authors: Trucharte Almudena , Carmen Valiente , Pacios Javier , Bruña Ricardo , Espinosa Regina , Peinado Vanesa , Pascual Teodoro , Martinez Anton P. , Maestu Fernando , Bentall Richard P. 
Published: October 2024

IntroductionMuch research on the treatment of paranoia has involved cognitive-behavioural interventions that address explicit social cognition processes. However, much of human cognition is preverbal or implicit, raising the possibility that such social judgements are implicated in paranoia. One type of implicit social cognition that has been investigated concerning paranoia is implicit self-esteem with some evidence that it may be possible to change implicit self-esteem using techniques based on conditioning theory. Therefore, the primary purpose of this research is to further evaluate the potential of this approach. At the same time, as a secondary purpose, we introduce a novel way of measuring social cognition that, we argue, has utility for investigating the psychological processes involved in paranoia.MethodWe conducted two proof-of-concept studies of a novel brief intervention based on evaluative conditioning, targeting implicit cognition. The first study was conducted with a large non-clinical sample, while the second study included a small series of psychotic patients. As part of our proof-of-concept evaluation of the potential of evaluative conditioning, we attempted to probe for neurophysiological changes following the intervention using magnetoencephalography in an exploratory way in the clinical sample.ResultsOur results revealed that both non-clinical and clinical participants in the experimental group showed a significant change in how they evaluated themselves in the social cognition task, which could be related to the perception of social information in a less threatening way. In addition, clinical participants in the experimental group showed changes in brain activity during the social cognition task, particularly in regions involved in emotional reactivity and mentalization processes.DiscussionOur results are encouraging, suggesting that implicit cognition is manipulable, that such manipulation affects underlying neurophysiological mechanisms, and that there may be an impact on paranoid symptoms. However, much more work is required to determine whether this approach can produce meaningful clinical change and be delivered in routine clinical settings. Finally, it is important to note that we are not claiming the clinical effectiveness of our intervention, which is in a very early stage of development. Our goal here is to demonstrate clinical possibilities that warrant further investigation
Sub-nA photovoltaic energy harvesting circuit for miniaturized battery-less sensor edges
Authors: Yoshimoto Kaisei , Yokoshiki Yasufumi , Tokuda Takashi 
Published: October 2024

Abstract
In this letter, we report on the photovoltaic energy harvesting circuit for miniaturized, battery-less sensor devices. To accumulate nanowatt power from ultra-small photovoltaic cells, it is essential to reduce the minimum operating current of the energy harvesting circuit. To reduce the minimum operating current, we propose a dual-capacitance voltage monitor (DCVM) which can overcome the issue of the voltage drop caused by the shoot-through current for switching. We designed the energy harvesting circuit including the DCVM in a 180 nm CMOS standard process, and successfully demonstrate the minimum operating current of 1 nA.
Analysis the Implementation of Independent Learning-Independent Campus Program based on Students’ Perceptions
Authors: Sahid Sahid , Rosidah Rosidah , Baharuddin Baharuddin 
Published: October 2024

Investigations of the independent learning-independent campus program still encounter obstacles in its implementation. This research is research that is motivated by the phenomenon of certain obstacles and problems faced by students when implementing independent learning-independent campus program in the mathematics department, FMIPA UNM, so it needs to be reviewed and carried out further analysis as material for further improvements. This research aims to explore student perceptions regarding the implementation of independent learning-independent campus program which is focused on the implementation of existing programs at independent learning-independent campus program which is implemented in the Mathematics Department of FMIPA UNM. This research is quantitative descriptive research using survey methods. The research was carried out at the Mathematics Education Study Program, Department of Mathematics, Faculty of Mathematics and Natural Sciences, State University of Makassar. The sample in this study were students in semester IV and semester VI from the FMIPA mathematics department who were selected purposively based on research interests and needs, namely students who took part in the independent learning-independent campus program. Data was analyzed descriptively to see students' perceptions of the implementation of the independent learning-independent campus program. Research finds that students majoring in mathematics at FMIPA UNM responded well to the MBKM program, it can be seen that the majority of students were interested in joining the program.
Stakeholders Pressure and Green Accounting Implementation in Kenyan Manufacturing Enterprises
Authors: Mbalu Paul Mwangangi , Otiende Dr. Isaac Otiende , Mwanzia Dr. Stephen Mwanzia , Gladys Wamiori Dr. Gladys Wamiori 
Published: October 2024

The objective of this study was to establish the influence of stakeholders’ pressure on the Green Accounting (GA) implementation in Kenyan manufacturing enterprises. Lack of sufficient research on the factors influencing GA implementation and the paucity of existing literature created the need for this study. Stakeholder theory was applied. Data were gathered using questionnaires that the researcher self-administered. The Cronbach's alpha (α) reliability test was applied to evaluate the internal consistency of the measurements. The investigation's primary emphasis was on 1,107 manufacturing firms that are Kenya Association of Manufacturers members. The sample consisted of 294 firms. To ensure that each data stratum was fairly represented in the analysis, stratified random sampling was used in the study. The study's results showed that stakeholder pressure significantly and favorably impacted Kenyan manufacturing companies' adoption of green accounting. The study came to the conclusion that manufacturing companies in Kenya ought to embrace and apply GA. The study recommends that manufacturing enterprises in Kenya prioritize the training and development of their accounting professionals in environmental sustainability and the importance of stakeholders in green accounting implementation journey. Stakeholders pressure is an integral part of green accounting and thus stakeholders are recommended to continue having requirements to the manufacturing firms to adopt green accounting.

Submitted

19th Jul 2024

Reviewed

27th Sep, 2024

Accepted

4th Oct 2024

Published

20th Oct 2024