bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Positive Psychological Interventions on Psychological Outcomes, Quality of Life, and Inflammation Biomarkers in Inflammatory Bowel Disease Patients
Authors: Liang Yongchun , Li Yunhua , Zhou Mingming 
Published: September 2024

This meta-analysis aimed to systematically evaluate the effects of positive psychological interventions on anxiety, depression, stress, mindfulness, hope, quality of life, and disease activity, as well as inflammation biomarkers, in patients with inflammatory bowel disease. Databases such as Cochrane Library, PubMed, EBSCO, Embase, Web of Science, China Biomedical Literature Database, China Knowledge Network, and WANFANG DATA were searched by two researchers from the time of each database’s creation to November 2022. A total of 14 randomized controlled trials (RCTs) with 1,191 patients were included. The results showed that positive psychological interventions were effective in reducing anxiety (standardized mean difference [SMD] = −0.81, 95% confidence interval [CI] [−1.33, −0.30], p = .002), depression (SMD = −0.86, 95% CI [−1.32, −0.41], p = .0002), and stress (SMD = −0.68, 95% CI [−1.05, −0.31], p = .0003), and significantly increased the level of hope (weighted mean difference [WMD] = 3.26, 95% CI [0.84, 5.68], p = .008), mindfulness (SMD = 0.59, 95% CI [0.30, 0.88], p < .0001), and quality of life (SMD = 0.61, 95% CI [0.09, 1.14], p = .02) of patients with inflammatory bowel disease. This suggests that positive psychological interventions can significantly improve positive psychology and reduce negative emotions in patients with inflammatory bowel disease.
The Impact of HLA-DQαβ Heterodimer Mismatch on Living Donor Kidney Allograft Outcomes
Authors: Charnaya Olga , Ishaque Tanveen , Hallett Andrew , Morris Gerald P. , Coppage Myra , Schmitz John L. , Timofeeva Olga , Lázár-Molnár Eszter , Zhang Aiwen , Krummey Scott , Hidalgo Luis , Segev Dorry L. , Tambur Anat R. , Massie Allan B. 
Published: September 2024

Background.
HLA-DQ mismatch has been identified as a predictor of de novo donor-specific HLA antibody formation and antibody-mediated rejection. There are insufficient data to guide the incorporation of DQ mismatch into organ allocation decisions.

Methods.
We used a retrospective longitudinal cohort of adult living donor kidney transplant recipients from 11 centers across the United States for whom high-resolution class II typing was available. HLA-DQαβ heterodimer allele mismatch was quantified for all donor-recipient pairs, and outcome data were obtained through linkage with the Scientific Registry of Transplant Recipients.

Results.
We studied 3916 donor-recipient pairs. Recipient characteristics were notable for a median age of 51 (38–61) y, primarily unsensitized, with 74.5% of the cohort having 0% calculated panel-reactive antibody, and 60.4% with private insurance, for a median follow-up time of 5.86 y. We found that the HLA-DQαβ allele and HLA-DR antigen mismatch were each individually associated with an increased hazard of all-cause graft failure (adjusted hazard ratio [aHR] DQ = 1.03 1.14 1.28; aHR DR = 1.03 1.15 1.328), death-censored graft failure (aHR DQ =1.01 1.19 1.40; aHR DR = 0.099 1.18 1.39), and rejection. Having 2 HLA-DQαβ allele mismatches further increased the hazard of rejection even when controlling for HLA-DR mismatch (aHR 1.03 1.68 2.74).

Conclusions.
HLA-DQαβ allele mismatch predicted allograft rejection even when controlling for HLA-DR antigen mismatch and were both independently associated with increased risk of graft failure or rejection in adult living kidney transplant recipients. Given the strong burden of disease arising from the HLA-DQ antibody formation, we suggest that HLA-DQαβ should be prioritized over HLA-DR in donor selection.
Risk of adverse pregnancy outcomes and impact of statin use in pregnant women with familial hypercholesterolemia
Authors: Svendsen Karianne , Christensen Jacob Juel , Igland Jannicke , Krogh Henriette Walaas , Mundal Liv J. , Jacobs David R. , Bogsrud Martin P. , Holven Kirsten B. , Retterstøl Kjetil 
Published: September 2024

AbstractBackground and aimsSparse data exist on the possible risk of adverse pregnancy outcomes in women with familial hypercholesterolemia (FH). We investigated associations between having a FH diagnosis and adverse pregnancy outcomes, and between statin exposure in pregnancy and adverse pregnancy outcomes among women with FH.MethodsThis registry-based study included 3869 pregnancies among 1869 women with FH and 68225 pregnancies among 33661 women from the general population. Data on adverse pregnancy outcomes were obtained from the Medical Birth Registry of Norway with data from 1967-2018. Data on pharmacy-dispensed statins were obtained from the Norwegian prescription database (2004-2018) in 1051 women with FH. Associations were presented as odds ratio (OR) with 95% CI from logistic regression adjusted for mother’s age, parity, and offspring’s birth year.ResultsWomen with FH had a higher risk of preeclampsia (OR 1.21 [1.00-1.46]), but lower risk for gestational diabetes (OR 0.58 [0.36-0.92]) and intrapartum hemorrhage during delivery (OR 0.81 [0.71-0.92]) compared to controls. No excess risk of adverse pregnancy outcome in offspring was observed for FH vs controls. Women with FH using statins in pregnancy (n=260) had a higher risk of having offspring with low (<2500 g) birth weight (OR 2.20 [1.11, 4.49]) compared to non-exposed women with FH (n=791).ConclusionsWomen with FH had lower risk of gestational diabetes and intrapartum hemorrhage during delivery and non-significantly higher risk of preeclampsia compared to controls. No difference in adverse pregnancy outcomes in the offspring was observed. Statin exposure in pregnancy was associated with a higher risk of having offspring with low birth weight among women with FH, and this association warrants further investigations.
Co-circulation of Clade Ia and Ib monkeypox virus in Kinshasa Province, Democratic Republic of the Congo, July - August 2024
Authors: Wawina-Bokalanga Tony , Akil-Bandali Prince , Kinganda-Lusamaki Eddy , Lokilo Emmanuel , Jansen Daan , Amuri-Aziza Adrienne , Makangara-Cigolo Jean-Claude , Pukuta-Simbu Elisabeth , Ola-Mpumbe Rilia , Kacita Cris , Paku-Tshambu Princesse , Dantas Pedro-Henrique L.F. , Luakanda Gradi , Nkuba-Ndaye Antoine , Matondo Meris , Bulabula Junior , Hasivirwe Vakaniaki Emmanuel , O’Toole Áine , De Block Tessa , Ngandu Christian , Hoff Nicole A. , Low Nicola , Subissi Lorenzo , Merritt Sydney , Muyembe-Tamfum Jean-Jacques , Liesenborghs Laurens , Peeters Martine , Delaporte Eric , Kindrachuk Jason , Rimoin Anne W. , Ahuka-Mundeke Steve , Rambaut Andrew , Mwamba Dieudonné , Vercauteren Koen , Mbala-Kingebeni Placide 
Published: September 2024

AbstractMpox cases have been reported in nearly all provinces of the Democratic Republic of the Congo as of August 2024. Monkeypox virus positive samples from Kinshasa, collected between July and mid-August 2024, were sequenced using a probe-based enrichment or optimized tiling sequencing protocol. With multiple introductions of both Clade Ia (7/12) and Ib (5/12), marking Kinshasa, and its Limete health zone specifically, as an area with co-circulation of both Clade I, a unique observation illustrating the growing complexity of Clade I mpox outbreaks in DRC.
Adverse events affecting recovery from seasonal influenza vaccination in the hypertensive population: A population-based pharmacovigilance analysis
Authors: Wu Hao , He Xiaona , Cao Yu , Gao Wei 
Published: September 2024

AbstractSeasonal influenza vaccination is crucial for preventing influenza and its complications. Data from the U.S. Vaccine Adverse Event Reporting System (VAERS) indicate a higher proportion of adverse events (AEs) after influenza vaccination in hypertensive people. However, there is limited evidence on AEs in hypertensive people following seasonal influenza vaccination. We collected a total of 4647 individuals on seasonal influenza vaccination and 6380 AEs from VAERS for hypertensive people aged 18 years or older from 1 January 2013 to 23 June 2023. We conducted propensity score matching (PSM) by adjusting for the demographic characteristics of the seasonal influenza-vaccinated hypertensive population and the season of onset. Cox regression analysis was used to calculate the risk ratio of reported adverse events (AEs) that affected recovery after seasonal influenza vaccination. Most AEs were nonserious and occurred within 48 hours. The most common AEs were general disorders and administration site conditions (therapeutic and non-therapeutic responses, inflammation) and musculoskeletal and connective tissue disorders (musculoskeletal and connective tissue pain and discomfort, bursal disorders, joint-related signs, and symptoms). All three types of seasonal influenza vaccines were associated with injection site reactions (47.07% trivalent influenza vaccine [TIA], hazard ratio, HR 2.04, 95% confidence interval, CI 1.22–3.40; 20.00% quadrivalent influenza vaccine [QIA], HR 2.81, 95% CI, 1.81–4.37; 67.48% influenza vaccine, unknown manufacturer [FLUX], HR 2.83, 95% CI, 1.12–7.15) and were the AEs affecting the largest proportion of delayed recoveries in the hypertensive population. Potential AEs following seasonal influenza vaccination may affect the recovery of the hypertensive population. The majority of AEs reported were general disorders, predominantly injection site reactions, and nonserious.
Women Empowerment and its Effect on Female Genital Mutilation in Sub-Sahara Africa: A study using Recent Demographic Health Surveys
Authors: Koray Munawar Harun , Mugisha John 
Published: September 2024

AbstractBackgroundWomen empowerment can enhance and improve women decsions and will power to negotiate and stand against sensitive issues that affect women’s health and sexuality. Practices such as Female Genital Mutilation (FGM) are generally sensitive issues that requires education and holistic interventions to enable its eradication, particularly in sub-Sahara Africa (SSA), where the practice is still pervasive. This study investigated the effect of women empowerment, using the Survey-base Women Empowerment (SWPER) Global index, on FGM in selected countries in SSA.MethodsThe study employed cross-sectional design using the most recent Demographic Health Survey (DHS) data from 10 SSA countries. A total of 49501 women who were either married or living with a partner and have a daughter age 0 – 14 years who is either circumcised or not. Pearson’s chi-square test was used to examine the association between women empowerment and daughter with FGM, and countries. Bivariate and multivariate logistic regressions were used to examine the predictors of FGM at a significance level of p ≤ 0.05 and 95% confidence interval. Complex survey design was considered in the analysis.Results49,501 participants were included in the study and 47.96% exhibited a positive attitude towards violence. Empowerment in SWPER domains were significantly associated with FGM (p < 0.0001), with Kenya and Tanzania exhibiting high levels of women empowerments and low prevalence of FGM. Medium and highly-empowered mothers had significantly lower odds of having a child with FGM in the bivariate regression models (p < 0.0001), compared to mothers with low empowerment levels. When adjusted for confounders, increasing age is associated with higher odds of FGM with mothers age 45-49 mothers having more than 4 times higher odds (AOR: 4.265, 95%CI: 3.466 – 5.248). Muslim mothers also had higher odds of having a child with FGM (AOR: 6.046; 95%CI: 5.605 – 6.521) compared to Christian mothers. An increase in the wealth index was also a protective factor against FGM (p < 0.0001). Circumcised mothers were more likely to have their female child circumcised (AOR: 5.527; 95%CI: 5.113 – 5.975) and female household heads were found to be protective factors against FGM (AOR: 0.846; 95%CI: 0.774 – 0.925).ConclusionThe study highlights a connection between women’s empowerment and FGM prevalence in SSA, highlighting the need to promote women’s autonomy and reject violence. Traditional norms and cultural support for FGM persist, particularly in Western Africa. Targeted empowerment initiatives, education, and strengthening legal frameworks can help reduce FGM prevalence.
Understanding the primary healthcare context in rural South and Southeast Asia: a village profiling study
Authors: Chew Rusheng , Ibna Zaman Sazid , Ara Joly Mst. Asfat , Uddin Didar , Nurullah Md , Callery James J , Perrone Carlo , Peto Thomas J , Phommasone Koukeo , Phyo Aung Pyae , Roobsoong Wanlapa , Sen Aninda , Vanna Moul , Chandna Arjun , Pongvongsa Tiengkham , Dysoley Lek , Day Nicholas PJ , Lubell Yoel , Maude Richard J 
Published: September 2024

AbstractThe use of comprehensive village profiles is one way of characterising contextual factors important for the implementation of primary healthcare interventions and service planning in rural areas. However, there are few such data available at the village level in rural South and Southeast Asia. This study aimed to address this gap, as well as compare high-level data from representative under-served and understudied villages across seven sites in five countries (Thailand (n=3), Cambodia, Laos, Myanmar, and Bangladesh). A survey-based approach using key informants supplemented by other relevant information sources was used to collect data from 687 of 707 villages participating in the South and Southeast Asian Community-based Trials Network. Data on four key health and socio-economic indicators (literacy rate, percentage of attended deliveries, percentage of fully-immunised children, and percentage of latrine coverage) as well as access to health services, public utilities, and education were collected and analysed using descriptive statistics. There was considerable variation between sites in terms of health and socio-economic indicators given that the countries are at different stages of development, and also between the three sites in Thailand. Five of the seven sites were highly diverse ethno-culturally and linguistically, and all were reliant on primary health centres as well as village health workers/village malaria workers as the main providers of primary healthcare. These were generally bypassed by severely ill patients in favour of first-level referral hospitals and private sector facilities in towns. While >75% of villages at each site were near to a primary school, educational attainment was generally low. Over 70% of villages at each site had mobile phone coverage and availability of electricity was high (≥65% at all sites bar Myanmar). These results illustrate the wide diversity of villages in rural South and Southeast Asia that need to be considered in public health research and policymaking.
Risks and long-term prognosis of new-onset heart failure afterde novopermanent pacemaker implantation: nationwide cohort study
Authors: Park Young Jun , Lee Sungjoo , Hong Sungjun , Kim Kyunga , Kim Juwon , Kim Ju Youn , Park Kyoung-Min , On Young Keun , Park Seung-Jung 
Published: September 2024

AbstractBackgroundPrevious studies on pacemaker-associated heart failure (PaHF) have predominantly analyzed relatively small, single-center datasets, mainly focusing on incidence and predictors. However, the clinical implications of PaHF on mortality, particularly in relation to standard HF medications or upgrading to cardiac resynchronization therapy (CRT), has been underexplored.MethodsUtilizing nationwide real-world data from the Korean National Health Insurance Service database, we analyzed 32,216 patients undergoing permanent pacemaker (PPM) implantation without preexisting HF between 2008 and 2019. The incidence, predictors, and mortality risk of PaFH were evaluated. To address potential immortal-time bias due to the time-dependent occurrence of PaHF, the time from the PPM implantation to the first diagnosis of PaHF was analyzed as a time-dependent covariate. For patients with PaHF, a propensity score-matched analysis was conducted based on CRT-upgrade status to explore the effect of CRT-upgrade on the risk of all-cause mortality.ResultsDuring the median 3.8-year follow-up period, PaHF and all-cause death occurred in 4170 (12.9%) and 6184 (19.2%) of the 32,216 PPM patients (42.3% male, mean age 70.6 years), respectively. PaHF development was closely associated with all-cause mortality, with a significantly higher mortality risk in the PaHF than in the non-PaHF group (hazard ratio [HR]=3.11, 95% confidence interval [CI]=2.93–3.32, P<0.001) after adjusting for immortal-time bias. The PaHF incidence and PaHF-associated mortality risk, although highest for the first six months post-PPM, did not disappear and increased again with follow-up time. In both the entire cohort (n=4170) and the propensity score-matched cohort (n=1685) of PaHF patients, CRT upgrade (HR=0.34, 95% CI=0.24–0.47, P<0.001), the use of beta-blockers (HR=0.75, 95% CI=0.61–0.93, P=0.010), and angiotensin receptor neprilysin inhibitor (ARNI) use (HR=0.28, 95% CI=0.14–0.54, P<0.001) were identified as potent protective factors against post-PaHF all-cause mortality.ConclusionsPaHF development independently predicted post-PPM mortality, while upgrading to CRT and the use of beta-blockers or ARNI were identified as favorable prognostic factors for post-PaHF overall survival. Therefore, for PaHF patients, an immediate change into CRT or conduction system pacing, may be required along with optimal HF medications owing to the ongoing mortality risk.
Should women have lower blood pressure targets than men? Sex differences in blood pressure and cardiovascular disease in the UK Biobank
Authors: Kelly Rebecca K , Harris Katie , Carcel Cheryl , Muntner Paul , Woodward Mark 
Published: September 2024

AbstractBackgroundRecent studies show that the risk of cardiovascular disease (CVD) increases from a lower nadir of systolic blood pressure (SBP) in women than men, and increases thereafter at a greater rate. This has led to a suggestion that sex-based SBP thresholds are required. We aimed to investigate sex differences in the associations of SBP and incident atherosclerotic CVD in a large prospective cohort.Methods420,649 UK Biobank participants with no prior history of CVD were included. Age-adjusted sex-specific risks, relative risks (RRs) and risk differences (RDs) relating SBP to CVD were estimated using Poisson and Cox regression.ResultsOver 13.2 years of follow-up there were 28,628 CVD events. CVD risks across BP levels showed a “J-shape”, and were higher in men than women at all BP levels. The lowest risks were at SBP 100-<105 mmHg (events per 10,000 person-years [95%CI]: 15.6 [11.8-23.1]) and 110-<115 (47.2 [41.8-53.0]) among women and men, respectively. Compared with SBP 100-<110, sex-specific RRs at above 120 were higher in women than men, but RDs were higher in men than women at all levels of SBP. Furthermore, compared to men at 100-<110 (i.e. the men with least risk), risks in women were lower at all levels of SBP below 170.ConclusionsCVD risk is lowest for women at a slightly lower SBP than men and RRs for CVD increase with SBP at a slightly steeper rate in women. However, both risks and RDs in women are never greater than in men. This evidence suggests that women should not have lower BP thresholds.Clinical PerspectiveWhat is New?While risks are higher at lower BP levels in women than men when both sexes are considered independently, consideration of the risks and sex-combined analyses do not support treating women at lower BP levels than men.What are the Clinical Implications?In line with 2017 ACC/AHA guideline, antihypertensive treatment thresholds should be based on absolute risk calculated from sex-specific algorithms, rather than BP level in isolation.Both risks and relative risks must be taken into account to understand sex-differences in the relationship of BP-CVD and whether these differences are clinically meaningful.
Single-shot detection of microscale tactile features
Authors: Reschechtko Sasha , Pangan Wylianne R. , Zadeh Reza Zeinal , Pruszynski J. Andrew 
Published: September 2024

AbstractTactile detection of very small features requires relative motion between the fingertip and a surface. The specific movement strategies that people use may be critical to maximize detection ability but little is known about the movement strategies people employ to support such detection. Here, human participants actively scanned a fingertip across a pair of silica wafers to detect which of the two contained a microscale feature (2, 6, and 10 μm height and 525 μm diameter). We constrained fingertip movement to ensure that participants would always contact the feature and would only contact the feature once. These procedures encouraged participants to use strategies that optimized detection rather than search and thus allowed us to more directly link movement strategies to detection. We also investigated the effects of fingertip movement direction and the finger used on detection. We found that participants were able to consistently detect microscale features as small as 2 μm on the basis of a single contact event. The contact forces that participants used were substantially higher than those observed in previous studies focused on tactile search or geometric feature extraction. Scanning speeds were slower than those found during tactile search but faster than those reported during geometric feature extraction. Taken in conjunction with the associations between detection and finger used as well as scan direction, our results suggest that control and consistency of fingertip movement may be a primary consideration for movement strategies that optimize tactile detection.
Immediate Modulation of the Blood Oxygenation Level-Dependent Signals by Dual-Site Transcranial Alternating Current Stimulation Propagates Across the Whole Brain
Authors: Hiromitsu Kentaro , Asai Tomohisa , Kadota Hiroshi , Imaizumi Shu , Kamata Masashi , Imamizu Hiroshi 
Published: September 2024

AbstractTranscranial alternating current stimulation (tACS) is assumed to target specific brain regions and modulate their activity. Recent discussions of tACS propose that, entraining the phase of brain activity to the stimulation current, stimulation effects extend globally across the whole brain based on phase differences. However, immediate online spatiotemporal propagation of resting-state blood oxygenation level-dependent (BOLD) signals within the brain due to multi-region stimulation remains unclear. The objectives of the present study were three-fold: 1) to elucidate the immediate online effect of tACS on BOLD signal, 2) to examine the extent of the influence on the brain when applying tACS, and 3) to explore whether variations in the phase difference between two brain regions result in differential effects on the stimulated areas and the whole brain. Through two experiments involving high-definition tACS with simultaneous measurements using a functional magnetic resonance imaging (fMRI), we revealed that the immediate online stimulation effects not only altered BOLD signals in the stimulated regions but also propagated across the whole brain in specific spatiotemporal patterns (functional networks). Stimulation effects were observed specifically in regions rich in neural fibres, including the grey and white matter, with no effect in regions containing cerebrospinal fluid. The timing of the signal value peaks depended on the stimulated region and functional networks, with a notable trend observed. Thus, tACS with a specific phase difference in two anatomically connected brain regions can immediately modulate online neural dynamics at both local and global scales.Graphical abstract