bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Buffering Effect of Parental Mediation in the Relationship between Adolescents' Cyberbullying Victimisation and Adjustment Difficulties
Authors: Wright Michelle F. 
Published: January 2017

As cyberbullying research advances, many researchers have focused on identifying factors that might reduce the negative consequences associated with cyberbullying victimisation. One prominent factor receiving attention is the role of parental mediation in digital technology use, and how such mediation reduces the risk of cybervictimisation. Parents utilise different mediation strategies (i.e. restrictive, co‐viewing, instructive), which could potentially contribute to differential patterns in the relationships between cyberbullying victimisation and the associated psychosocial adjustment difficulties (i.e. depression, loneliness, anxiety). The present study investigated this proposal among 568 US (53% female) adolescents in the eighth grade (age ranging from 13–15 years), utilising a longitudinal design. Cyberbullying victimisation was related positively to restrictive mediation and Time 2 depression, anxiety and loneliness, while such associations were negative for co‐viewing mediation and instructive mediation. High levels of co‐viewing mediation and instructive mediation made the relationship of cyberbullying victimisation to Time 2 (1 year later) depression more negative. The results of this study are discussed in terms of the supportive role of parents in adolescents' digital technology use. Copyright © 2017 John Wiley & Sons, Ltd.‘Identifying factors that might reduce the negative consequences associated with cyberbullying victimisation’Key Practitioner Messages

Cyberbullying victimisation is linked positively to depression, anxiety and loneliness as well as restrictive mediation.
Cyberbullying victimisation is related negatively to co‐viewing mediation and instructive mediation.
Co‐viewing mediation and instructive mediation buffer against adolescents' depression and anxiety resulting from cyberbullying victimisation.
‘Co‐viewing mediation and instructive mediation buffer against adolescents' depression and anxiety resulting from cyberbullying victimisation’
Bifunctional Hierarchical Zeolite‐Supported Silver Catalysts for the Conversion of Glycerol to Allyl Alcohol
Authors: Lari Giacomo M. , Chen Zupeng , Mondelli Cecilia , Pérez‐Ramírez Javier 
Published: January 2017

AbstractThe establishment of suitable processes for the conversion of glycerol into allyl alcohol is hindered by the fast deactivation of solid acids in the dehydration of the substrate to acrolein and by the requirement of hydrogen donors to enhance the selectivity of the subsequent reduction step. In this work, silver nanoparticles deposited onto a hierarchical ZSM‐5 zeolite are proved to be an effective bifunctional catalyst to conduct the two reactions in the gas phase and in the presence of hydrogen by using a continuous fixed‐bed reactor. The acidic function was accomplished by using a ZSM‐5 zeolite modified by facile alkaline and acid treatments, which decreased the amount of Lewis acid centers while preserving the amount of Brønsted acid centers, and introduced an auxiliary network of intracrystalline mesopores, thus boosting the selectivity to acrolein (62 %) and the resistance to coking. Upon screening of various metals supported on the aluminosilicate, silver was identified as a superior hydrogenation catalyst, enabling a relatively high activity with >50 % allyl alcohol selectivity. Tuning of the metal loading, temperature, pressure, and contact time led to 15 % yield of allyl alcohol, thus approaching the state‐of‐the‐art transfer hydrogenation systems, and stable behavior for 100 h on stream. Our results highlight the advantage of conducting the two transformations over a bifunctional material rather than over two separate single‐function solids.
Comparison of an AC‐taxane versus AC‐free regimen and paclitaxel versus docetaxel in patients with lymph node‐positive breast cancer: Final results of the National Surgical Adjuvant Study of Breast Cancer 02 trial, a randomized comparative phase 3 study
Authors: Watanabe Toru , Kuranami Masaru , Inoue Kenichi , Masuda Norikazu , Aogi Kenjiro , Ohno Shinji , Iwata Hiroji , Mukai Hirofumi , Uemura Yukari , Ohashi Yasuo 
Published: January 2017

BACKGROUNDIn postoperative patients with breast cancer, the combination of an anthracycline and cyclophosphamide (AC) followed by a taxane is a standard regimen. In the current study, the authors examined whether AC could be safely omitted, and compared the effectiveness of paclitaxel versus docetaxel.METHODSFemale postoperative patients with axillary lymph node‐positive breast cancer were eligible for enrollment in this phase 3, open‐label, randomized controlled trial at 84 centers in Japan. Patients were randomized to 4 cycles of doxorubicin at a dose of 60 mg/m2 and cyclophosphamide at a dose of 600 mg/m2 (AC) followed by 4 cycles of paclitaxel at a dose of 175 mg/m2 (ACpT) or AC followed by 4 cycles of docetaxel at a dose of 75 mg/m2 (ACdT), or 8 cycles of paclitaxel (PTx) or docetaxel (DTx) every 3 weeks. The primary endpoint was disease‐free survival (DFS). Secondary endpoints included overall survival adverse events. The authors adopted a 2 × 2 factorial design to examine the AC containing‐regimens (ACpT and ACdT) versus the AC free‐regimens (PTx and DTx), and the paclitaxel‐containing regimens (ACpT and PTx) versus the docetaxel‐containing regimens (ACdT and DTx).RESULTSOf 1060 patients, 1049 were treated and included in the intention‐to‐treat population. The DFS results did not demonstrate noninferiority between the AC‐containing and the AC‐free regimens (hazard ratio [HR], 1.19; 95% confidence interval [95% CI], 0.982‐1.448 [Pnoninferiority = .30]). Better outcomes were noted in patients treated with the docetaxel‐containing regimens compared with the paclitaxel‐containing regimens with respect to DFS (HR, 0.72; 95% CI, 0.589‐0.875 [P = .0008]) and overall survival (HR, 0.75; 95% CI, 0.574‐0.980 [P = .035]). Neutropenia, nausea, and vomiting were found to occur more often in the AC‐containing arms, whereas the incidence of edema was greater in the docetaxel‐containing treatment arms.CONCLUSIONSNoninferiority in DFS was not demonstrated between the AC‐containing and AC‐free regimens. Compared with a similar regimen of paclitaxel, docetaxel appeared to increase the DFS. Cancer 2017;123:759–68. © 2016 American Cancer Society.
A study of over 35,000 women with breast cancer tested with a 25‐gene panel of hereditary cancer genes
Authors: Buys Saundra S. , Sandbach John F. , Gammon Amanda , Patel Gayle , Kidd John , Brown Krystal L. , Sharma Lavania , Saam Jennifer , Lancaster Johnathan , Daly Mary B. 
Published: January 2017

BACKGROUNDAs panel testing becomes more common in clinical practice, it is important to understand the prevalence and trends associated with the pathogenic variants (PVs) identified. This is especially true for genetically heterogeneous cancers, such as breast cancer (BC), in which PVs in different genes may be associated with various risks and cancer subtypes. The authors evaluated the outcomes of genetic testing among women who had a personal history of BC.METHODSA total of 35,409 women with a single diagnosis of BC who underwent clinical genetic testing with a 25‐gene panel were included in the current analysis. Women with multiple BCs and men with BC were excluded. The frequency and distribution of PVs were assessed for the overall cohort, among women with triple‐negative BC (TNBC) (n = 4797), and by age at diagnosis.RESULTSPVs were identified in 9.3% of women tested; 51.5% of PVs were identified in genes other than breast cancer 1 (BRCA1) and BRCA2, including checkpoint kinase 2 (CHEK2) (11.7%), ataxia telangiectasia mutated (ATM; ATM serine/threonine kinase) (9.7%), and partner and localizer of BRCA2 (PALB2) (9.3%). The prevalence of PVs in BRCA1, PALB2, BRCA1‐associated RING domain 1 (BARD1), BRCA1‐interacting protein C‐terminal helicase 1 (BRIP1), and RAD51 paralog C (RAD51C) was statistically higher among women with TNBC. The PV rate was higher among women aged <40 years, lower among women aged >59 years, and relatively constant (8.5%‐9.0%) among women who were diagnosed between ages 40 and 59 years.CONCLUSIONSThese results demonstrate that panel testing increased the number of women identified as carrying a PV in this cohort compared with BRCA testing alone. Furthermore, the proportion of women identified who carried a PV in this cohort did not decrease between ages 40 and 59 years. Cancer 2017;123:1721–1730. © 2017 American Cancer Society.
The utility of abbreviated patient‐reported outcomes for predicting survival in early stage colorectal cancer
Authors: Hsu Tina , Speers Caroline H. , Kennecke Hagen F. , Cheung Winson Y. 
Published: January 2017

BACKGROUNDPatient‐reported outcomes (PROs) are increasingly used in clinical settings. Prior research suggests that PROs collected at baseline may be associated with cancer survival, but most of those studies were conducted in patients with breast or lung cancer. The objective of this study was to determine the correlation between prospectively collected PROs and cancer‐specific outcomes in patients with early stage colorectal cancer.METHODSPatients who had newly diagnosed stage II or III colorectal cancer from 2009 to 2010 and had a consultation at the British Columbia Cancer Agency completed the brief Psychosocial Screen for Cancer (PSSCAN) questionnaire, which collects data on patients' perceived social supports, quality of life (QOL), anxiety and depression, and general health. PROs from the PSSCAN were linked with the Gastrointestinal Cancers Outcomes Database, which contains information on patient and tumor characteristics, treatment details, and cancer outcomes. Cox regression models were constructed for overall survival (OS), and Fine and Gray regression models were developed for disease‐specific survival (DSS).RESULTSIn total, 692 patients were included. The median patient age was 67 years (range, 26‐95 years), and the majority had colon cancer (61%), were diagnosed with stage III disease (54%), and received chemotherapy (58%). In general, patients felt well supported and reported good overall health and QOL. On multivariate analysis, increased fatigue was associated with worse OS (hazard ratio [HR], 1.99; P = .00007) and DSS (HR, 1.63; P = .03), as was lack of emotional support (OS: HR, 4.36; P = .0003; DSS: HR, 1.92; P = .02).CONCLUSIONSAlthough most patients described good overall health and QOL and indicated that they were generally well supported, patients who experienced more pronounced fatigue or lacked emotional support had a higher likelihood of worse OS and DSS. These findings suggest that abbreviated PROs can inform and assist clinicians to identify patients who have a worse prognosis and may need more vigilant follow‐up. Cancer 2017;123:1839–1847. © 2017 American Cancer Society.
What do these scores mean? Presenting patient‐reported outcomes data to patients and clinicians to improve interpretability
Authors: Snyder Claire F. , Smith Katherine C. , Bantug Elissa T. , Tolbert Elliott E. , Blackford Amanda L. , Brundage Michael D. ,   the PRO Data Presentation Stakeholder Advisory Board
Published: January 2017

BACKGROUNDPatient‐reported outcomes (PROs) (eg, symptoms, functioning) can inform patient management. However, patients and clinicians often have difficulty interpreting score meaning. The authors tested approaches for presenting PRO data to improve interpretability.METHODSThis mixed‐methods study included an Internet survey of cancer patients/survivors, oncology clinicians, and PRO researchers circulated via snowball sampling, plus individual in‐person interviews. Clinical importance was conveyed using 3 approaches (presented in random order): normal score range shaded green, concerning scores circled in red, and red threshold lines indicating normal versus concerning scores. Versions also tested 2 approaches to score directionality: higher = more (better for function, worse for symptoms) and higher = better for both function and symptoms. Qualitative data from online comments and in‐person interviews supplemented quantitative results on interpretation accuracy, clarity, and the “most useful” format.RESULTSThe survey included 1113 respondents: 627 survivors, 236 clinicians, and 250 researchers, plus 10 patients and 10 clinicians who were purposively sampled interviewees. Interpretation accuracy ranged from 53% to 100%. The formats in which higher = better were interpreted more accurately versus those in which higher = more (odds ratio [OR], 1.30; 95% confidence interval [CI], 1.07‐1.58) and were more likely to be rated “very”/“somewhat” clear (OR, 1.39; 95% CI, 1.13‐1.70) and “very” clear (OR, 1.36; 95% CI, 1.18‐1.58). Red circle formats were interpreted more accurately than green‐shaded formats when the first format presented (OR, 1.29; 95% CI, 1.00‐1.65). Threshold‐line formats were more likely to be rated “very” clear than green‐shaded (OR, 1.43; 95% CI, 1.19‐1.71) and red‐circled (OR, 1.22, 95% CI, 1.02‐1.46) formats. Threshold lines were most often selected as “most useful.”CONCLUSIONSThe current results support presenting PRO data with higher = better directionality and threshold lines indicating normal versus concerning scores. Cancer 2017;123:1848–1859. © 2017 The Authors. Cancer published byWiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations aremade.
Comparative effectiveness of first‐line radiofrequency ablation versus surgical resection and transplantation for patients with early hepatocellular carcinoma
Authors: Kutlu Onur C. , Chan Jennifer A. , Aloia Thomas A. , Chun Yun S. , Kaseb Ahmed O. , Passot Guillaume , Yamashita Suguru , Vauthey Jean‐Nicolas , Conrad Claudius 
Published: January 2017

BACKGROUNDSignificant controversy exists as to which treatment modality is most effective for small, solitary hepatocellular carcinomas (HCCs): radiofrequency ablation (RFA), surgical resection (RXN), or transplantation (TXP). Size cutoff values ranging from 20 to 50 mm have been proposed to achieve complete ablation. The current study compares outcomes between RFA, RXN, and TXP as first‐line therapy for patients with HCC tumors measuring as large as 50 mm.METHODSThe Surveillance, Epidemiology, and End Results database was queried for patients with HCC tumors measuring up to 50 mm who were treated with RFA, RXN, or TXP between 2004 and 2013. Overall survival (OS) and disease‐specific survival (DSS) were examined in patients with tumors measuring ≤20 mm, 21 to 30 mm, or 31 to 50 mm. The impact of an increase in tumor size of only 5 mm beyond 30 mm was evaluated by also examining outcomes in patients with tumors measuring 31 to 35 mm.RESULTSOf 1894 cases, patients with HCC tumors measuring ≤20 mm and 21 to 30 mm demonstrated no difference in OS or DSS regardless of whether RFA and RXN was used. RFA was associated with a worse OS and DSS than TXP, whereas there was no difference in OS observed between RXN and TXP. In patients with tumors measuring 31 to 50 mm, OS and DSS were worse with RFA compared with RXN or TXP. Most important, the inferior DSS and OS noted with RFA were observed with only a 5‐mm increase in tumors measuring >30 mm.CONCLUSIONSAlthough RFA frequently is used as first‐line treatment of HCC tumors measuring as large as 50 mm, it is associated with worse results than RXN or TXP for tumors measuring >30 mm. To the best of the authors' knowledge, the results of the current study are the first to demonstrate that although RFA is an appropriate option for patients with HCC tumors measuring ≤30 mm, its use for tumors even slightly larger than 30 mm is associated with inferior outcomes. Cancer 2017;123:1817–1827. © 2017 American Cancer Society.
Quantitative Analysis of Cellular Senescence in Culture and In Vivo
Authors: Zhao Jing , Fuhrmann‐Stroissnigg Heike , Gurkar Aditi U. , Flores Rafael R. , Dorronsoro Akaitz , Stolz Donna B. , St. Croix Claudette M. , Niedernhofer Laura J. , Robbins Paul D. 
Published: January 2017

AbstractCellular senescence refers to the irreversible growth arrest of normally dividing cells in response to various types of stress. Cellular senescence is induced by telomere shortening due to repeated cell division, which causes a DNA damage response, as well as genotoxic, oxidative, and inflammatory stress. Strong mitogenic signaling, such as oncogene activation, also drives cells into a senescent state. Senescent cells express a specific subset of genes, termed the senescence‐associated secretory phenotype (SASP), including pro‐inflammatory factors, growth factors, and matrix metalloproteinases, which together promote non‐cell autonomous, secondary senescence. Clearance of senescent cells that accumulate with age improves health span, implicating cellular senescence as a contributing factor to the aging process. Thus, there is a need for methods to identify and quantify cellular senescence, both in cultured cells and in vivo. Here, methods for the most well‐characterized and widely used senescent assays are described, from cell morphology and senescence‐associated β‐galactosidase (SA‐βgal) staining to nuclear biomarkers, SASP, and altered levels of tumor suppressors. © 2017 by John Wiley & Sons, Inc.
Big biology meets microclimatology: defining thermal niches of ectotherms at landscape scales for conservation planning
Authors: Isaak Daniel J. , Wenger Seth J. , Young Michael K. 
Published: January 2017

AbstractTemperature profoundly affects ecology, a fact ever more evident as the ability to measure thermal environments increases and global changes alter these environments. The spatial structure of thermalscapes is especially relevant to the distribution and abundance of ectothermic organisms, but the ability to describe biothermal relationships at extents and grains relevant to conservation planning has been limited by small or sparse data sets. Here, we combine a large occurrence database of >23 000 aquatic species surveys with stream microclimate scenarios supported by an equally large temperature database for a 149 000‐km mountain stream network to describe thermal relationships for 14 fish and amphibian species. Species occurrence probabilities peaked across a wide range of temperatures (7.0–18.8°C) but distinct warm‐ or cold‐edge distribution boundaries were apparent for all species and represented environments where populations may be most sensitive to thermal changes. Warm‐edge boundary temperatures for a native species of conservation concern were used with geospatial data sets and a habitat occupancy model to highlight subsets of the network where conservation measures could benefit local populations by maintaining cool temperatures. Linking that strategic approach to local estimates of habitat impairment remains a key challenge but is also an opportunity to build relationships and develop synergies between the research, management, and regulatory communities. As with any data mining or species distribution modeling exercise, care is required in analysis and interpretation of results, but the use of large biological data sets with accurate microclimate scenarios can provide valuable information about the thermal ecology of many ectotherms and a spatially explicit way of guiding conservation investments.
The interplay between natural and sexual selection in the evolution of sexual size dimorphism inSceloporuslizards (Squamata: Phrynosomatidae)
Authors: Jiménez‐Arcos Víctor H. , Sanabria‐Urbán Salomón , Cueva del Castillo Raúl 
Published: January 2017

AbstractSexual size dimorphism (SSD) evolves because body size is usually related to reproductive success through different pathways in females and males. Female body size is strongly correlated with fecundity, while in males, body size is correlated with mating success. In many lizard species, males are larger than females, whereas in others, females are the larger sex, suggesting that selection on fecundity has been stronger than sexual selection on males. As placental development or egg retention requires more space within the abdominal cavity, it has been suggested that females of viviparous lizards have larger abdomens or body size than their oviparous relatives. Thus, it would be expected that females of viviparous species attain larger sizes than their oviparous relatives, generating more biased patterns ofSSD. We test these predictions using lizards of the genusSceloporus. After controlling for phylogenetic effects, our results confirm a strong relationship between female body size and fecundity, suggesting that selection for higher fecundity has had a main role in the evolution of female body size. However, oviparous and viviparous females exhibit similar sizes and allometric relationships. Even though there is a strong effect of body size on female fecundity, once phylogenetic effects are considered, we find that the slope of male on female body size is significantly larger than one, providing evidence of greater evolutionary divergence of male body size. These results suggest that the relative impact of sexual selection acting on males has been stronger than fecundity selection acting on females withinSceloporuslizards.
Temporal complexity of southernBeaufortSea polar bear diets during a period of increasing land use
Authors: McKinney Melissa A. , Atwood Todd C. , Iverson Sara J. , Peacock Elizabeth 
Published: January 2017

AbstractFrom 2000 to 2013, use of land as a seasonal habitat by polar bears (Ursus maritimus) of the southern Beaufort Sea (SB) subpopulation substantially increased. This onshore use has been linked to reduced spatial and temporal availability of sea ice, as well as to the availability of subsistence‐harvested bowhead whale (Balaena mysticetus) bone piles. Here, we evaluated the role of climate conditions on consumption of traditional ice‐associated prey relative to onshore bowhead whale bone piles. We determined seasonal and interannual trends in the diets ofSBpolar bears using fatty acid‐based analysis during this period of increasing land use. Diet estimates of 569SBpolar bears from 2004 to 2012 showed high seasonal fluctuations in the proportions of prey consumed. Higher proportions of bowhead whale, as well as ringed seal (Pusa hispida) and beluga whale (Delphinapterus leucas), were estimated to occur in the winter–spring diet, while higher proportions of bearded seal (Erignathus barbatus) were estimated for summer–fall diets. Trends in the annual mean proportions of individual prey items were not found in either period, except for significant declines in the proportion of beluga in spring‐sampled bears. Nonetheless, in years following a high winter Arctic oscillation index, proportions of ice‐associated ringed seal were lower in the winter–spring diets of adult females and juveniles. Proportions of bowhead increased in the winter–spring diets of adult males with the number of ice‐free days over the continental shelf. In one or both seasons, polar bears that were in better condition were estimated to have consumed less ringed seal and/or more bowhead whale than those in worse condition. Therefore, climate variation over this recent period appeared to influence the extent of onshore vs. on‐ice food use, which in turn, appeared to be linked to fluctuating condition ofSBpolar bears.