bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of trihalomethanes in the air of two indoor swimming pool facilities using different type of chlorination and different types of water
Authors: Nitter Therese B. , Kampel Wolfgang , Svendsen Kristin v. H. , Aas Bjørn 
Published: October 2017

Abstract
Certain aspects of the distribution of disinfection by-products (DBPs) in the air of indoor swimming pools, the exposure of the users, and possible health effects, have not been well documented. To determine the distribution of trihalomethanes (THMs), measurements were performed at 0.05 m, 0.60 m and 1.50 m above the water surface. These heights were chosen to measure the exposure in the breathing zone of the users. Air samples were collected from two indoor swimming pool facilities in Norway. Facility 1 uses calcium hypochlorite and facility 2 uses sodium hypochlorite for water treatment. In facility 2, one of the swimming pools is filled with 33% seawater, while the other pools in this study were filled with freshwater. Higher values were measured at 0.05 m compared to 1.50 m. Negligible differences between the measurements at 0.60 m and 1.50 m above floor levels were obtained. On average, 282% higher concentrations of total THM (tTHM) were measured in facility 2. Different disinfection products and ventilation concepts are possible explanations. Swimmers are exposed to higher concentrations compared to users by the poolside. For future studies, it is crucial to measure as close to the water surface as possible.
Modeling biosorption of Cr(VI) onto Ulva compressa L. from aqueous solutions
Authors: Aid Asma , Amokrane Samira , Nibou Djamel , Mekatel Elhadj , Trari Mohamed , Hulea Vasile 
Published: October 2017

Abstract
The marine biomass Ulva compressa L. (ECL) was used as a low-cost biosorbent for the removal of Cr(VI) from contaminated aqueous solutions. The operating variables were optimized: pH ∼ 2, initial concentration of 25 mg/L, solid/liquid ratio of 6 g/L and a temperature of 50 °C, leading to an uptake elimination of 96%. A full factorial experimental design technique enabled us to obtain a mathematical model describing the Cr(VI) biosorption and to study the main effects and interactions among operational parameters. The equilibrium isotherm was analyzed by the Langmuir, Freundlich and Dubinin–Radushkevich (D-R) models; it has been found that the adsorption process follows well the Langmuir model. Kinetic studies showed that the pseudo-second order model describes suitably the experimental data. The thermodynamic parameters indicated an endothermic heat and a spontaneity of the Cr(VI) biosorption onto ECL.
Untargeted Metabolomics Provides Insight into the Mechanisms Underlying Resistant Hypertension
Authors: Wawrzyniak Renata , Mpanga Arlette Yumba , Struck-Lewicka Wiktoria , Kordalewska Marta , Polonis Katarzyna , Patejko Małgorzata , Mironiuk Monika , Szyndler Anna , Chrostowska Marzena , Hoffmann Michał , Smoleński Ryszard T. , Kaliszan Roman , Narkiewicz Krzysztof , Markuszewski Michał J. 
Published: October 2017

Background:
Resistant hypertension (RH) affects about 15-20% of treated hypertensive
patients worldwide. RH increases the risk of cardiovascular events such as myocardial
infarction and stroke by 50%. The pathological mechanisms underlying resistance to treatment
are still poorly understood.

Objective:
The main goal of this pilot study was to determine and compare plasma metabolomic
profiles in resistant and non-resistant hypertensive patients.

Methods:
We applied untargeted metabolomic profiling in plasma samples collected from 69
subjects with RH and 81 subjects with controlled hypertension. To confirm patients’ compliance
to antihypertensive treatment, levels of selected drugs and their metabolites were determined
in plasma samples with the LC-ESI-TOF/MS technique.

Results:
The results showed no statistically significant differences in the administration of
antihypertensive drug in the compared groups. We identified 19 up-regulated and 13 downregulated
metabolites in the RH.

Conclusion:
The metabolites altered in RH are linked to oxidative stress and inflammation,
endothelium dysfunction, vasoconstriction and cell proliferation. Our results may generate
new hypothesis about RH development and progression.
The Use of Naphthoquinones and Furano-naphthoquinones as Antiinvasive Agents
Authors: Tsang Nga Yi , Chik Wai I , Sze Lai Pan , Wang Ming-Zhong , Tsang Siu Wai , Zhang Hong-Jie 
Published: October 2017

Background:
Cancer is a leading cause of mortality in the world and metastasis is to blame.
A number of naphthoquinones (NQs) have shown ability to reduce cancer stemness and metastatic potential.
Furano-naphthoquinones (FNQs), which is a class of NQ characterized by the incorporation of
an additional furan ring, have demonstrated improved anti-cancer potency as compared to the other
classes of NQs.

Objective:
In this study, the natural origins, synthetic routes and derivatives of migrastatic NQs were
reviewed. The anti-invasive and anti-metastatic mechanisms of NQs and the more powerful FNQs in
targeting cancer were also discussed.

Methods:
The articles related to the anti-invasive mechanisms of NQs were comprehensively reviewed.
The plant origins, synthetic routes and antitumor effects of more than 360 FNQs were also
covered and presented according to their chemical structures.

Results:
Anti-cancer NQs inhibit cancer invasion by acting on epithelial-mesenchymal transition
(EMT), cancer stem cells (CSCs) and signal transducer and activator of transcription 3 (STAT3) signaling.
BBI608, a natural FNQ, has entered phases I and II clinical trials. It has been regarded as a potential
candidate for new-generation lead compound acting directly on CSCs to overcome the problem
of chemotherapy resistance. Apart from the plant-derived FNQs, there are a number of synthetic FNQs
that were found to intervene in cancer invasion and metastasis.

Conclusion:
The anti-invasive mechanisms of NQs have been thoroughly studied. FNQs generally
show higher anti-cancer activity than that of NQs. The mechanisms of action of FNQs are worth further
investigation.
Fighting Type-2 Diabetes: Present and Future Perspectives
Authors: Yu Cai-Guo , Fu Ying , Fang Yuan , Zhang Ning , Sun Rong-Xin , Zhao Dong , Feng Ying-Mei , Zhang Bao-Yu 
Published: October 2017

Background:
Type-2 diabetes mellitus accounts for 80-90% of diabetic patients.
So far, the treatment of diabetes mainly aims at elevating insulin level and lowering glucose
level in the peripheral blood and mitigating insulin resistance. Physiologically, insulin secretion
from pancreatic β cells is delicately regulated. Thus, how insulin-related therapies could
titrate blood glucose appropriately and avoid the occurrence of hypoglycemia remains an important
issue for decades. Similar question is addressed on how to attenuate vascular complication
in diabetic subjects.

Methods:
We overviewed the evolution of each class of anti-diabetic drugs that have been
used in clinical practice, focusing on their mechanisms, clinical results and cautions.

Results:
Glucagon-like peptide-1 receptor agonists stimulate β cells for insulin secretion in
response to diet but not in fasting stage, which make them superior than conventional insulinsecretion
stimulators. DPP-4 inhibitors suppress glucagon-like peptide-1 degradation. Sodium/
glucose co-transporter 2 inhibitors enhance glucose clearance through urine excretion.
The appearance of these new drugs provides new information about glycemic control. We update
the clinical findings of Glucagon-like peptide-1 receptor agonists, DPP-4 inhibitors and
Sodium/glucose cotransporter 2 inhibitors in glycemic control and the risk or progression of
cardiovascular disease in diabetic patients. Stem cell therapy might be an alternative tool for
diabetic patients to improve β cell regeneration and peripheral ischemia. We summarize the
clinical results of mesenchymal stem cells transplanted into patients with diabetic limb and
foot.

Conclusion:
A stepwise intensification of dual and triple therapy for individual diabetic patient
is required to achieve therapeutic target.
Burden of Mortality Attributable to Diagnosed Diabetes: A Nationwide Analysis Based on Claims Data From 65 Million People in Germany
Authors: Jacobs Esther , Hoyer Annika , Brinks Ralph , Kuss Oliver , Rathmann Wolfgang 
Published: October 2017

OBJECTIVE
In Germany, as in many other countries, nationwide data on mortality attributable to diagnosed diabetes are not available. This study estimated the absolute number of excess deaths associated with diabetes (all types) and type 2 diabetes in Germany.

RESEARCH DESIGN AND METHODS
A prevalence approach that included nationwide routine data from 64.9 million people insured in the German statutory health insurance system in 2010 was used for the calculation. Because nationwide data on diabetes mortality are lacking in Germany, the mortality rate ratio from the Danish National Diabetes Register was used. The absolute number of excess deaths associated with diabetes was calculated as the number of deaths due to diabetes minus the number of deaths due to diabetes with a mortality that was as high as in the population without diabetes. Furthermore, the mortality population-attributable fraction was calculated.

RESULTS
A total of 174,627 excess deaths were due to diabetes in 2010, including 137,950 due to type 2 diabetes. Overall, 21% of all deaths in Germany were attributable to diabetes and 16% were attributable to type 2 diabetes. Most of the excess deaths (34% each) occurred in the 70- to 89-year-old age-group.

CONCLUSIONS
In this first nationwide calculation of excess deaths related to diabetes in Germany, the results suggest that the official German estimates that rely on information from death certificates are grossly underestimated. Countries without national cohorts or diabetes registries could easily use this method to estimate the number of excess deaths due to diabetes.
Impacto da saúde bucal na qualidade de vida de adultos de diferentes níveis socioeconômicos
Authors: SILVA Edna Alves , BATISTA Marília Jesus , SOUSA Maria da Luz Rosário de 
Published: October 2017

ObjetivoAvaliar o impacto da saúde bucal na qualidade de vida de adultos de diferentes níveis socioeconômicos. MétodosEste estudo transversal foi realizado em adultos de 35 a 59 anos de idade,sendo 113 usuários do serviço odontológico público e 97, do serviço privado da cidade de São Paulo. Dados sociodemográficos, de utilização dos serviços odontológicos e de qualidade de vida (Oral Health Impact Profile-14) foram obtidos através de um questionário. A saúde bucal foi avaliada pelo índice Cariados, perdidos e obturados-dentes. O Oral Health Impact Profile total (severity) e Oral Health Impact Profile prevalence (uma ou mais respostas “frequentemente” ou “sempre”) foram avaliados nas sete dimensões entre os dois grupos de adultos através do teste Mann Whitney e do teste do Qui-quadrado. ResultadosA média do Oral Health Impact Profile dos adultos do serviço público foi 11,5 (±11,3) e do serviço privado foi 5,9 (±9,1). O grupo do serviço público apresentou maior prevalência de impacto negativo, 76,6% (n=49), quando comparado ao grupo do serviço privado, que foi 23,4% (n=15). Os grupos diferiram em quatro dimensões na prevalência do Oral Health Impact Profile: limitação física, desconforto psicológico, incapacidade psicológica e incapacidade social (p<0,05).As médias do Oral Health Impact Profile por dimensões foram diferentes com relação ao tipo de serviço utilizado entre esses adultos, com exceção da limitação física (p>0,05). ConclusãoAtravés dos resultados deste estudo, pode-se concluir que o impacto da saúde bucal na qualidade de vida foimaior no grupo dos adultos do serviço público, que apresentaram baixo nível socioeconômico.
TREND OF CULTIVATED AREA AND PRODUCTION IN VARIOUS FIELD CROPS IN ODISHA
Authors: Vandra Dhiren , Chaudhury Suman Kalyan , Sahu Anil Kumar 
Published: October 2017

This paper attempts to highlights the actual cultivated area in Odisha and various suitable crops which will give better income. The results indicate that almost 70 percent population in Odisha is dependent on agriculture. The agriculture sector contributes only about 26 percent of the GSDP. The declining agriculture growth coupled with declining productivity in agriculture. It is evident from the study that increase in production is due to some steps taken by state government, such as seed replacement program, increased irrigation facilities, use of fertilizers, farm mechanization, soil testingand	restoration of soli health and fertility, agricultural research education, soil reclamation program, agricultural extension service. Therefore proper implementations of policies are more important. Thus, the paper suggests that government should take initiatives for improvement of agriculture and such step provides an opportunity to increase production and productivity substantially of the state.
Pengembangan Minuman Kedelai Hitam untuk Ibu Menyusui
Authors: Pramitasari Rianita 
Published: October 2017

Genistein and daidzein could stimulate the prolactin hormone that play a role in breastmilk production. Black soybean contain genistein and daidzein which has a potent to developed as the functional food for breastfeeding mothers. The purpose of this study was to get the optimal formula, determine the nutritional value, and genistein and daidzein contents of black soybean beverage. The beverages were made from 5 variations of time soaking (0, 3, 6, 9, and 12 hours). Further analysis of sensory and nutritional value from the beverages. The results showed that the beverage with 12 hours time soaking was the most preferred beverage by panelists. One serving (150 ml) of selected beverage was able to supply 3.65% of carbohydrate needs; 4.75% of protein needs; 3.33% of fat needs; and 3.68% of total energy based on Recommended Dietary Allowance of Indonesian breastfeeding mother per day. It contained 2.78 ± 0.25 mg/g of genistein and 0.087 ± 0.13 mg/g of daidzein.
HUBUNGAN KEBIASAAN BELAJAR DAN KEPERCAYAAN DIRI DENGAN HASIL BELAJAR MATEMATIKA SISWA KELAS VIII SMP N 27 BATAM
Authors: Agustyaningrum Nina , Suryantini Silfia 
Published: October 2017

Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan yang signifikan antara kebiasaan belajar dan kepercayaan diri dengan hasil belajar matematika siswa kelas VIII SMP N 27 Batam. Jenis penelitian ini adalah korelasional dengan populasi seluruh siswa kelas VIII SMP N 27 Batam yang terdiri dari 129 siswa sedangkan metode pengambilan sampel adalah sampel jenuh. Instrumen yang digunakan dalam penelitian ini berupa angket yang telah di uji validitas dan reliabilitasnya. Teknik analisis data yang digunakan adalah dengan uji signifikansi koefisien korelasi dengan uji F dan uji t. Hasil penelitian menunjukkan (1) terdapat hubungan yang signifikan antara kebiasaan belajar dengan hasil belajar matematika siswa kelas VIII SMP N 27 Batam dengan besar hubungan yang termasuk kategori hubungan kuat; (2) terdapat hubungan yang signifikan antara kepercayaan diri dengan hasil belajar matematika siswa kelas VIII SMP N 27 Batam dengan besar hubungan 0,5 yang termasuk kategori hubungan cukup; (3) terdapat hubungan yang signifikan antara kebiasaan belajar dan kepercayaan diri secara bersama-sama dengan hasil belajar matematika siswa kelas VIII SMP N 27 Batam dengan besar hubungan 0,6 yang termasuk kategori hubungan kuat.
MODEL PENGEMBANGAN WEB KOMUNITAS UNTUK MENDUKUNG PROSES INTERACTIVE DISTANCE LEARNING
Authors: Daru April Firman , Adhiwibowo Whisnumurti 
Published: October 2017

Kegiatan pembelajaran atau proses belajar yang selama ini terjadi mengharuskan kehadiran pengajar dan peserta ajar dalam suatu tempat dan waktu yang sama, sehingga banyak keterbatasan yang dialami. Bila pengajar atau siswa tidak hadir, maka pelaksanaan pembelajaran akan bermasalah.Web komunitas merupakan media berbagi dan berkomunikasi antar user. Dengan menambahkan beberapa fasilitas seperti privat Chat, Public Chat, Forum dan video sharing akan dapat dijadikan sebagai sarana proses pembelajaran. Penulis akan melakukan penelitian dengan memanfaatkan kemajuan teknologi internet untuk mengembangankan web berbasis komunitas sebagai pendukung proses Interactive Distance Learning. Metode pengembangan sistem yang dipakai adalah System Development Life Cycle (SDLC).Tujuan dari penelitian ini adalah terbentuknya web komunitas yang dapat dimanfaatkan sebagai sarana saling berbagi informasi, diskusi dan tempat penyampaian materi secara on line, sehingga proses belajar dapat dilakukan setiap saat, walaupun tanpa kehadiran pengajar atau siswa ditempat yang sama. Kata Kunci : web komunitas, Interaktif, Pembelajaran jarak jauh.
Visualisasi Termal Permukaan Tangan Manusia sebagai Alternatif Bahan Ajar Fisika Medis
Authors: Suryantari Risti , Flaviana Flaviana 
Published: October 2017

Salah satu kemampuan dasar yang harus dikuasai di bidang fisika medis adalah topik fisika termal. Dalam bidang medis dikenal metode termografi, yaitu salah satu metode diagnosa penyakit yang didasarkan pada perbedaan temperatur antar jaringan tubuh manusia dalam bentuk citra. Perkembangan teknik termografi selain dengan menggunakan kamera termal, adalah dengan menggunakan lembaran Thermochromic Liquid Crystal (TLC). TLC memiliki respon terhadap perubahan temperatur permukaan yang ditunjukkan dengan perubahan warna sehingga TLC dapat digunakan untuk memvisualisasikan permukaan tangan manusia berdasarkan distribusi temperatur pada setiap bagian permukaan tangan. Hasil visualisasi ini dapat menjadi contoh konkret bahwa temperatur permukaan tubuh manusia tidaklah merata, serta bagaimana temperatur permukaan tangan berubah akibat faktor eksternal seperti temperatur ruang. Secara kuantitatif perbedaan temperatur permukaan tangan dapat ditunjukkan dengan parameter nilai hue dari citra HSV dengan menerapkan teknik pengolahan citra, dimana nilai mean hue meningkat seiring dengan meningkatnya temperatur. Selain itu diperoleh pula nilai temperatur rata-rata permukaan tangan subyek dalam kondisi sehat, pada temperatur ruang 18°C, yang berada dalam ruangan selama 10 menit, adalah pada rentang 25°C - 28°C. Hasil ini dapat dimanfaatkan sebagai alternatif bahan ajar dalam bidang fisika medis, khusunya yang berhubungan dengan fisika termal.
DIMENSI ESTETIKA PERTUNJUKAN SALUANG DENDANG DI MINANGKABAU DALAM BAGURAU
Authors: Sriyanto Sriyanto 
Published: October 2017

Dimensi estetika dalam pertunjukan Saluang-Dendang di Minangkabau amat kompleks. Setiap unsur saling terkait ketika “proses” pertunjukan sedang berlansung. Keterlibatan pemain dan penonton “bersama-sama”sangat menentukan berjalannya pertunjukan. Secara konvensional kualitas estetika bergantung pada tiga unsur penggarapan yaitu: pemahaman, sikap (etika), dan kemampuan (skill). Ketiganya harus sinergisitas, karena merupakan modal utama pemain Saluang Dendang dan penonton dalam “Bagurau”. Dimensi itulah yang dapat meningkatkan kualitas pertunjukan Saluang Dendang dalam Bagurau.
Trend of home or hospital delivery and child birth among Muslim women of Biratnagar, Nepal
Authors: Pokhrel Babu Ram , Sharma P , Jha N 
Published: October 2017

Background: Maternal morbidity and mortality remains one of the biggest public health challenges in Nepal. This paper explores the trend of home or hospital delivery and child birth in certain ethnic group. The illiteracy women’s low socio economic status in the society, lack of access and difficult geographical rugged terrain are major reasons for not delivering children in health institutions in Nepal.Objective: To find out the trend of hospital or home delivery among Muslim women of Biratnagar city.Methods: Cross-sectional study was conducted among 200 Muslim women of ward 7 of Biratnagar municipality. They were interviewed to assess their health seeking trend of home or hospital delivery and child birth along with factors associated with the use of health services. Information's on usages of health services, education level, family structure, and occupational status information were also collected using a pre-tested and structured questionnaire.Results: The overall institutional delivery in the study population was 24.5%. Illiteracy, low socio-economic status, and poverty in women are the major challenging features of not delivering babies in health institutions.Conclusion: Only one fourth of the women of the study population had hospital/health institutional delivery. Hospital deliveries were seen among the educated women with many antenatal visits. Therefore female education must be encouraged in this community. Health Renaissance 2015;13 (1): 68-76
A Method for the New Materialism
Authors: Tejada Jaime Moreno 
Published: October 2017

Kawa, Nicholas C. 2016. Amazonia in the Anthropocene: People, Soils,
Plants, Forests. Austin: University of Texas Press. [e-book].Starosielski, Nicole. 2015. The Undersea Network. Durham, NC: Duke University
Press.Tsing, Anna L. 2015. The Mushroom at the End of the World: On the Possibility
of Life in Capitalist Ruins. Princeton, NJ: Princeton University Press.
Rehabilitation modality and onset differentially influence whisker sensory hypersensitivity after diffuse traumatic brain injury in the rat
Authors: Thomas Theresa Currier , Stockhausen Ellen Magee , Law L. Matthew , Khodadad Aida , Lifshitz Jonathan 
Published: October 2017

Background: As rehabilitation strategies advance as therapeutic interventions, the modality and onset of rehabilitation after traumatic brain injury (TBI) are critical to optimize treatment. Our laboratory has detected and characterized a late-onset, long-lasting sensory hypersensitivity to whisker stimulation in diffuse brain-injured rats; a deficit that is comparable to visual or auditory sensory hypersensitivity in humans with an acquired brain injury. Objective: We hypothesize that the modality and onset of rehabilitation therapies will differentially influence sensory hypersensitivity in response to the Whisker Nuisance Task (WNT) as well as WNT-induced corticosterone (CORT) stress response in diffuse brain-injured rats and shams. Methods: After midline fluid percussion brain injury (FPI) or sham surgery, rats were assigned to one of four rehabilitative interventions: (1) whisker sensory deprivation during week one or (2) week two or (3) whisker stimulation during week one or (4) week two. At 28 days following FPI and sham procedures, sensory hypersensitivity was assessed using the WNT. Plasma CORT was evaluated immediately following the WNT (aggravated levels) and prior to the pre-determined endpoint 24 hours later (non-aggravated levels). Results: Deprivation therapy during week two elicited significantly greater sensory hypersensitivity to the WNT compared to week one ( p < 0.05), and aggravated CORT levels in FPI rats were significantly lower than sham levels. Stimulation therapy during week one resulted in low levels of sensory hypersensitivity to the WNT, similar to deprivation therapy and naïve controls, however, non-aggravated CORT levels in FPI rats were significantly higher than sham. Conclusion: These data indicate that modality and onset of sensory rehabilitation can differentially influence FPI and sham rats, having a lasting impact on behavioral and stress responses to the WNT, emphasizing the necessity for continued evaluation of modality and onset of rehabilitation after TBI.