bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent Shoulder Instability in a Young, Active, Military Population and Its Professional Implications
Authors: Flint James H. , Pickett Adam , Owens Brett D. , Svoboda Steven J. , Peck Karen Y. , Cameron Kenneth L. , Biery John , Giuliani Jeffrey , Rue John-Paul 
Published: May 2017

Background: Shoulder instability is a topic of significant interest within the sports medicine literature, particularly regarding recurrence rates and the ideal treatment indications and techniques. Little has been published specifically addressing the occupational implications of symptomatic recurrent shoulder instability. Hypothesis: Previous arthroscopic repair will continue to be a significant predisposing factor for recurrent instability in a young, active population, and that recurrent instability may have a negative effect on college graduation and postgraduate occupational selection. Study Design: Case series. Level of Evidence: Level 4. Methods: We conducted a retrospective review of approved medical waivers for surgical treatment of anterior shoulder dislocation or instability prior to matriculation at the US Military Academy or the US Naval Academy for the graduating classes of 2010 to 2013. Statistical analysis was performed to determine the incidence and risk factors for recurrence and to determine the impact on graduation rate and occupation selection. Results: Fifty-nine patients were evaluated; 34% developed recurrent anterior instability. Patients with previous arthroscopic repair had a significantly higher incidence of recurrence (38%, P = 0.044). Recurrent shoulder instability did not significantly affect graduation rates or self-selected occupation ( P ≥ 0.05). Conclusion: There is a significant rate of recurrent shoulder instability after primary surgical repair, particularly among young, active individuals. In addition, arthroscopic repair resulted in a significantly higher recurrence rate compared with open repair in our population. Surgical repair for shoulder instability should not necessarily preclude young individuals from pursuing (or being considered for) occupations that may place them at greater risk of recurrence. Clinical Relevance: The risk of recurrent instability is greater than the rate typically described, which may suggest that some subpopulations are at greater risk than others. A unique data point regarding instability is the effect on occupation selection.
Results of the interim analysis of the EORTC randomized phase III CATNON trial on concurrent and adjuvant temozolomide in anaplastic glioma without 1p/19q co-deletion: An Intergroup trial.
Authors: Van Den Bent Martin J. , Erridge Sara , Vogelbaum Michael A. , Nowak Anna K. , Sanson Marc , Brandes Alba Ariela , Wick Wolfgang , Clement Paul M. , Baurain Jean-Francois , Mason Warren P. , Wheeler Helen , Chinot Olivier L. , Weller Michael , Golfinopoulos Vassilis , Aldape Ken , Dinjens Winand N.M. , Wesseling Pieter , Gorlia Thierry , Kros Johan M , Baumert Brigitta G. 
Published: May 2017

LBA2000 Background: The benefit of adding chemotherapy to radiotherapy (RT) in newly diagnosed anaplastic glioma without 1p/19q co-deletion is unknown. The CATNON trial investigated the impact of adjuvant and/or concurrent chemotherapy with temozolomide (TMZ) in these tumors. Methods: Eligible were patients with newly diagnosed WHO grade III glioma without 1p/19q co-deletion, ≥ 18 years, and WHO performance status (PS) 0-2. All patients received RT 59.4 Gy in 33 fractions, and in a 2 x 2 factorial design were randomized to: RT alone; RT with concurrent daily 75 mg/m2 TMZ; RT followed with 12 cycles of 150-200 mg/m2 adjuvant TMZ day 1-5/4 weeks; or RT with both concurrent and 12 cycles of adjuvant TMZ. Stratification factors included O6-methyl-guanine DNA methyltransferase ( MGMT) promoter methylation and PS. Primary endpoint was overall survival (OS). 748 patients and 534 events were needed to detect a HR reduction of 0.775 for both concurrent and adjuvant TMZ. An interim analysis was foreseen after 219 events (41%), and required a p value of 0.0084 for rejecting the Null hypothesis of no OS difference. Results: Between Dec 2007 and Aug 2015 748 patients were randomized. On Oct 6, 2015 the interim analysis was conducted based on 221 events (median follow-up: 27 months). The analysis showed a HR reduction for OS of 0.645 (95% CI 0.450, 0.926; p= 0.0014) after adjuvant TMZ (arms iii and iv). MGMT status could be determined in 74% of patients, and was found methylated in 42% of them. MGMT methylation was prognostic for OS (HR 0.54, 95% CI 0.38, 0.77; p= 0.001), but at this stage did not predict improved outcome to adjuvant TMZ. For progression free survival (PFS), the risk adjusted HR of adjuvant TMZ was 0.586 (95% CI 0.472, 0.727; p < 0.0001). Conclusions: 12 cycles adjuvant TMZ improve OS in anaplastic glioma without 1p/19q co-deletion. Further follow-up will elucidate the role of concurrent TMZ . Molecular studies to address the impact of isocitrate dehydrogenase (IDH) mutational status and methylation profiling are ongoing. Clinical trial information: NCT00626990. [Table: see text]
Polyglutamine length-dependent toxicity from α1ACT inDrosophilamodels of spinocerebellar ataxia type 6
Authors: Tsou Wei-Ling , Qiblawi Sultan H. , Hosking Ryan R. , Gomez Christopher M. , Todi Sokol V. 
Published: May 2017

ABSTRACTSpinocerebellar ataxia type 6 (SCA6) is a neurodegenerative disease that results from abnormal expansion of a polyglutamine (polyQ) repeat. SCA6 is caused by CAG triplet repeat expansion in the gene CACNA1A, resulting in a polyQ tract of 19-33 in patients. CACNA1A, a bicistronic gene, encodes the α1A calcium channel subunit and the transcription factor, α1ACT. PolyQ expansion in α1ACT causes degeneration in mice. We recently described the first Drosophila models of SCA6 that express α1ACT with a normal (11Q) or hyper-expanded (70Q) polyQ. Here, we report additional α1ACT transgenic flies, which express full-length α1ACT with a 33Q repeat. We show that α1ACT33Q is toxic in Drosophila, but less so than the 70Q version. When expressed everywhere, α1ACT33Q-expressing adults die earlier than flies expressing the normal allele. α1ACT33Q causes retinal degeneration and leads to aggregated species in an age-dependent manner, but at a slower pace than the 70Q counterpart. According to western blots, α1ACT33Q localizes less readily in the nucleus than α1ACT70Q, providing clues into the importance of polyQ tract length on α1ACT localization and its site of toxicity. We expect that these new lines will be highly valuable for future work on SCA6.
Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport
Authors: Robinson Christopher L. , Evans Richard D. , Briggs Deborah A. , Ramalho Jose S. , Hume Alistair N. 
Published: May 2017

ABSTRACT
Microtubules and F-actin, and their associated motor proteins, are considered to play complementary roles in long- and short-range organelle transport. However, there is growing appreciation that myosin/F-actin networks can drive long-range transport. In melanocytes, myosin-Va and kinesin-1 have both been proposed as long-range centrifugal transporters moving melanosomes into the peripheral dendrites. Here, we investigated the role of kinesin-1 heavy chain (Kif5b) and its suggested targeting factor Rab1a in transport. We performed confocal microscopy and subcellular fractionation, but did not detect Kif5b or Rab1a on melanosomes. Meanwhile functional studies, using siRNA knockdown and dominant negative mutants, did not support a role for Kif5b or Rab1a in melanosome transport. To probe the potential of Kif5b to function in transport, we generated fusion proteins that target active Kif5b to melanosomes and tested their ability to rescue perinuclear clustering in myosin-Va-deficient cells. Expression of these chimeras, but not full-length Kif5b, dispersed melanosomes with similar efficiency to myosin-Va. Our data indicate that kinesin and microtubules can compensate for defects in myosin-Va and actin-based transport in mammals, but that endogenous Kif5b does not have an important role in transport of melanocytes due to its inefficient recruitment to melanosomes.
The flexible clock: predictive and reactive homeostasis, energy balance and the circadian regulation of sleep–wake timing
Authors: Riede Sjaak J. , van der Vinne Vincent , Hut Roelof A. 
Published: May 2017

ABSTRACT
The Darwinian fitness of mammals living in a rhythmic environment depends on endogenous daily (circadian) rhythms in behavior and physiology. Here, we discuss the mechanisms underlying the circadian regulation of physiology and behavior in mammals. We also review recent efforts to understand circadian flexibility, such as how the phase of activity and rest is altered depending on the encountered environment. We explain why shifting activity to the day is an adaptive strategy to cope with energetic challenges and show how this can reduce thermoregulatory costs. A framework is provided to make predictions about the optimal timing of activity and rest of non-model species for a wide range of habitats. This Review illustrates how the timing of daily rhythms is reciprocally linked to energy homeostasis, and it highlights the importance of this link in understanding daily rhythms in physiology and behavior.
Rats concatenate 22 kHz and 50 kHz calls into a single utterance
Authors: Hernandez Christine , Sabin Mark , Riede Tobias 
Published: May 2017

ABSTRACTTraditionally, the ultrasonic vocal repertoire of rats is differentiated into 22 kHz and 50 kHz calls, two categories that contain multiple different call types. Although both categories have different functions, they are sometimes produced in the same behavioral context. Here, we investigated the peripheral mechanisms that generate sequences of calls from both categories. Male rats, either sexually experienced or naïve, were exposed to an estrous female. The majority of sexually naïve male rats produced 22 kHz and 50 kHz calls on their first encounter with a female. We recorded subglottal pressure and electromyographic activity of laryngeal muscles and found that male rats sometimes concatenate long 22 kHz calls and 50 kHz trill calls into an utterance produced during a single breath. The qualitatively different laryngeal motor patterns for both call types were produced serially during the same breathing cycle. The finding demonstrates flexibility in the laryngeal–respiratory coordination during ultrasonic vocal production, which has not been previously documented physiologically in non-human mammals. Since only naïve males produced the 22 kHz-trills, it is possible that the production is experience dependent.
Self-Assembly of Hyperbranched Protic Poly(ionic liquid)s with Variable Peripheral Amphiphilicity
Authors: Korolovych Volodymyr F , Erwin Andrew J , Stryutsky Alexandr , Mikan Emily K , Shevchenko Valery V , Tsukruk Vladimir V 
Published: May 2017

Abstract
We demonstrated that the aggregation behavior of hyperbranched amphiphilic protic poly(ionic liquid)s (HBP-ILs) can be controlled by varying not only the number of peripheral hydrophobic arms and nature of counterions. Additionally, increasing the hydrophobicity of the HBP-ILs led to a condensed monolayer phase at the air-water interface. The balance of intermolecular interactions mediated by the presence of the ionic liquid component in the inner shell of micelles determines the final morphology in solution and at interfaces.
Helical Folding of π-Conjugated Polymers Bearing Glucose-Linked Biphenyl Units in the Main Chain: Application to Circularly Polarized Luminescence Materials
Authors: Ikai Tomoyuki , Shimizu Sho , Kudo Tomoya , Maeda Katsuhiro , Kanoh Shigeyoshi 
Published: May 2017

Abstract
We have synthesized a series of chiral π-conjugated polymers bearing glucose-linked biphenyl units in the main chain through copolymerizations of a key diethynyl compound (GLB-1), containing the structural element of naturally-occurring ellagitannin, with various diiodoaryls. The circular dichroism and circularly polarized luminescence properties of the obtained polymers were investigated in solution and the solid state. Based on a comparative study using the corresponding unimer model compounds, poly-3 and poly-4 bearing (oligo)thiophene-type comonomer units are considered to be able to fold into an excess one-handed helical conformation in solution and the solid state under an appropriate exterior environment. In contrast, analogous polymers bearing p- and m-phenylene residues as comonomer units did not form regular higher-ordered structures. We also observed that poly-3 and poly-4 efficiently emitted left-handed circularly polarized light with a corresponding fluorescence region arising from their helical chirality, and possessed dissymmetry factors of approximately 1.0 × 10−2 for the film state.
From healthcare assistant to student operating department practitioner—are you ready for the ODP challenge?
Authors: Rodger Daniel , Mahoney Chris 
Published: May 2017

This article will explore some of the barriers and challenges that a healthcare assistant (HCA) may encounter while on their journey to becoming a student operating department practitioner (ODP). Working as an HCA is often assumed to give individuals an advantage when considering a move up the healthcare career ladder; however, this may not always be the case. There are a number of unique challenges that prospective students must consider and overcome in order to successfully negotiate the transition to theatre healthcare professional.
Methods for Incorporating Stakeholder Engagement into Clinical Trial Design
Authors: Ehlers Anne P. , Davidson Giana H. , Deeney Kimberly , Talan David A. , Flum David R. , Lavallee Danielle C. 
Published: May 2017

Context: Lack of engagement with healthcare stakeholders results in missed
opportunities to understand translation of evidence into practice.Case: Stakeholder
engagement is a key component of the Comparing Outcomes of Drugs and Appendectomy (CODA)
Study, a pragmatic clinical trial funded by PCORI to evaluate the effectiveness of
antibiotics versus urgent appendectomy for acute uncomplicated appendicitis. We provide
a framework for developing a stakeholder coordinating center (SCC) and describe two
examples of how stakeholder engagement can inform study
development.Findings: Coordinating engagement activities through the SCC established a
commitment to the important partnership with stakeholders. It also facilitated
communication and provided a central mechanism for obtaining input on key decisions such
as development of patient-centered consent documents and appropriate stopping rules for
a specific sub-population of patients with appendicitis.Major themes: Translatable
lessons include thoughtful planning for engagement, identifying stakeholders with a
direct interest in the study conduct and findings, and integration of input received
into the decisions that drive the conduct of the study.Conclusions: Standards for
conducting patient-centered research should address the ability to successfully engage
patients by demonstrating the capacity to recruit study participants, engage them over
the duration of the study, and disseminate findings that are congruent with stakeholder
needs. The process of sharing important clinical research findings has improved patient
care, and we believe that dissemination of novel engagement strategies can lead to
increased success in study design and execution.
Theoretical Determination of a Thermogravimetric Model of Oak Cork (Quercus variabilis) Using Málek Kinetic Analysis
Authors: Shangguan Weiwei , Chen Zhangjing , Song Xiaozhou , Lei Yafang 
Published: May 2017

Abstract
The purpose of this study was to determine the expression of a kinetic model and the determination of kinetic parameters for cork. Thermal analysis kinetics of cork and impurities (sclereids and lenticels) were studied by thermogravimetric (TG) curves. The Málek method was used to obtain kinetic parameters in this experiment. Reconstruction models of y(α) and z(α) were compared with standard curves to determine appropriate kinetic models. The results showed that the RO(n) model was suitable to describe the dynamic process of cork, sclereids, and lenticels. The expressions of kinetic models were f(α) = (1 − α)4.89 for cork, f(α) = (1 − α)5.82 for sclereids, and f(α) = (1 − α)5.00 for lenticels. The natural log values ln A were 19.56, 28.90, and 28.88 ln s−1 for cork, sclereids, and lenticels, respectively. Fitting errors of parameters for cork, sclereids, and lenticels were less than 5 percent. The fitted conversion rate and curves of mass fraction were in good agreement with experimental data. Obtaining the kinetic model and parameters provides a basis for prediction of thermal properties of cork.
The beautiful, the bizarre, and the brutal: Dario Argento’s rhetoric of simulational aesthetics
Authors: Hurley Gavin F. 
Published: May 2017

Abstract
This article develops a theory of rhetoric to explain why contemporary audiences still enjoy and adhere to Dario Argento’s early horror films, specifically films spanning the years 1970 to 1982. The theory blends Jean Baudrillard’s concepts of hyperreality and simulation with Kenneth Burke’s understanding of rhetoric, persuasion and transcendence to explain how Argento’s cinematic vision transports viewers to a plane of aesthetic simulation whereby ‘pure persuasion’ unfolds. By illustrating specific examples from his films, including Suspiria (1977), Inferno (1980), Tenebrae (1982) and The Bird with the Crystal Plumage (1970), this article plots Argento’s evolution – and eventual abandonment – of the aesthetic simulation approach. This article argues that his aesthetically simulative approach coincided with the international success of his earlier films in the late 1970s and early 1980s: success that has significantly waned with his more recent films. This trend demonstrates the persuasive power held by Argento’s early art: a unique rhetoric that can benefit the horror genre as a whole.
No, everything is not all right: Supernatural horror as pessimistic argument
Authors: Stoneman Ethan , Packer Joseph 
Published: May 2017

Abstract
Historically, common belief and opinion have not been overly receptive to the tenets of philosophical pessimism. Ideas such as ‘Progress is illusory’, ‘The world is malignantly useless’, and ‘Life itself is perhaps little more than a constant dying’ simply rub most people the wrong way – and understandably so. According to the philosophical pessimist Peter Zapffe, when confronted by pessimistic ideas and argumentation most people have recourse to four ingrained, anti-pessimistic strategies: distraction, isolation, anchoring, and sublimation. Collectively, these strategies constitute a group of rhetorical liabilities that go a long way in explaining pessimism’s ongoing rhetorical inefficacy. Responding to that impasse, this article attempts to vindicate pessimism of its apparent rhetorical failing, arguing that pessimism can achieve rhetorical viability by foregoing traditional models of argumentation and opting instead for a less straightforwardly rational mode of argument. Such a mode, we claim, is exemplified by a particular strand of supernatural horror literature, namely, weird fiction. Through an examination of several representative weird tales, we show how weird fiction, by creating a sense of uncanny fear, functions rhetorically to undermine readers’ adherence to anti-pessimistic biases. In so doing, weird fiction fosters the creeping sense that all might not be right with the world.
Fault lines in Under the Skin (Glazer, 2013): An ethics and aesthetics of the ‘monstrous’
Authors: Roche David 
Published: May 2017

Abstract
An adaptation of Michel Faber’s 2000 novel about alien invasion that updates the scifi horror tradition of the 1970s in an art-cinema mode, Under the Skin (Glazer, 2013) offers a stellar example of the ‘monstrous’ as both figure and form. Generally speaking, the interstitiality of the ‘monstrous’ demands strategies grounded in the disconnection between categories (image and sound, diegetic and nondiegetic), some of which have become horror movie clichés. Under the Skin is no exception. Its aesthetics of instability, correlated to a ‘monstrous’ figure that casts a defamiliarizing gaze on our world before attempting to ‘become human’, produces a complex subtext on contemporary alienation and identity politics, that puts the viewer in a position where he or she must both take moral responsibility for the categories he or she constructs (such as the ’monstrous’), and experience the mysterious physicality at the core of life itself.
Fear and utopia in the millennial zombie: Digging deep inside Snyder’s Dawn of the Dead
Authors: Cloyd Nathanael J. 
Published: May 2017

Abstract
This article analyses Zack Snyder’s 2004 remake of Dawn of the Dead through Fredric Jameson’s three horizons of textual interpretation to demonstrate how the film, as an example of the third-strain millennial zombie narrative, supports a socially conservative ideology while simultaneously pointing to the Utopian possibility of communal action in the face of an overwhelming threat. The first horizon compares the formal differences of the visual effects between the remake and Romero’s 1978 original, showing how the removal of the original’s campy special effects repurposes the millennial zombie as a threat to conservative culture, not a vehicle for social satire as Romero had hoped. The second horizon, viewing the remake as a post-9/11 film, sees the symbolic conflict of social classes globalize and manifest as the human-capitalist-American bourgeoisie versus the zombie as the anti-American-terrorist proletariat. The third horizon, focusing on the historic progression of the means of production, sees the film as functioning through the politics of fear and the personalization of fear to serve as a conservative, capitalist economic motivator, while simultaneously inspiring the Utopian hope that humanity might be able to work together as a community.
On situating painting: An interview with Karin Kneffel
Authors: Manghani Sunil 
Published: May 2017

Abstract
Karin Kneffel came to prominence in the 1990s, known for her finely rendered portraits of animals, interiors and still-life paintings. Her handling of light, shadow and the complex interplay of reflective surfaces leads to challenging illusionist spaces. Through striking juxtapositions, foreshortening and exaggerated scales, Kneffel transforms otherwise overlooked objects. In this interview, the artist offers critical reflections on her practice. The interview is divided into three strands: (1) Situated Painting, which begins with specific considerations about the political conditions within which one ‘works’ as an artist; (2) Situations of Painting, which turns attention to painting as medium and form; and (3) Situating Painting, which examines both practical and aesthetic considerations of displaying work, and in particular an exhibition at the Mies van der Rohe Pavilion in Barcelona.
Baggage reclaim: Some thoughts on feminism and painting
Authors: Fortnum Rebecca 
Published: May 2017

Abstract
This article calls for a reappraisal of the feminist discussion around painting in relation to contemporary practices by women, suggesting that all painting by women has something to offer feminist critical thought. Playfully using Judy Chicago’s reflections and strategies as a frame, the article explores how contemporary painters have engaged with the histories and communities of women to form new models of scholarship and practice. It examines the projects of painters Melissa Gordon, Nadia Hebson and the Obscure Secure group (Jacqueline Utley, Hayley Field and Claudia Böse) whose artwork forms a ‘live’ response to the legacy of little known and undervalued women artists. The article concludes by examining the notion of the painterly gesture and develops a feminist context in which to examine the materiality and processes of painting, with reference to the perspectives of Dana Schutz and Jutta Koether among others. It suggests Helen Molesworth’s historically defined quality of ambivalence can be seen resurfacing as a critical position within contemporary painting by women.