bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Neotropical otter Lontra longicaudis: a comprehensive update on the current knowledge and conservation status of this semiaquatic carnivore
Authors: Rheingantz Marcelo Lopes , Santiago‐Plata Victor Manuel , Trinca Cristine Silveira 
Published: July 2017

Abstract

The Neotropical otter Lontra longicaudis is a widespread semiaquatic carnivore living in a wide variety of environments in both fresh‐water and salt‐water ecosystems. We summarise the current knowledge on distribution, ecology, behaviour, evolution and conservation status of the species, and highlight the main threats that have been affecting it as well as priority actions for securing its survival.
The current geographical range of Lontra longicaudis is discussed, as well as several efforts that have been made to update knowledge of the range. Throughout its known distribution area, the Neotropical otter has high genetic diversity, and recent molecular research suggests that variations in genetic diversity are related to geography. Taxonomic issues regarding the existence of subspecies persist, mainly due to limited sampling in key portions of the species’ range.
Although the Neotropical otter is widely distributed in Latin America and has flexible behaviour, it is subjected to a variety of threats, which lead this otter to be officially considered Threatened in several countries within its geographical range.
The species still faces an uncertain future due to the impact of human activities, thus justifying its classification as Near Threatened in the International Union for Conservation of Nature's Red List. The real level of human‐otter conflicts and the impact of modified environments on Neotropical otter populations are still unclear, and must be a priority focus of future studies.
There is an urgent need to increase our knowledge on aspects of the Neotropical otter's biology, such as reproduction, generation time, behaviour, physiology, distribution limits, sanitary aspects, evolution and taxonomy. Understanding these topics is vital to ensure the long‐term survival of the species, both at the local and at the regional scale, as well as to provide the basis for environmental education actions involving local riverside human communities
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Logical Form and the Vernacular Revisited
Authors: Botterell Andrew , Stainton Robert J. 
Published: July 2017

AbstractWe revisit a debate initiated some 15 years ago by Ray Elugardo and Robert Stainton about the domain of arguments. Our main result is that arguments are not exclusively sets of linguistic expressions. Instead, as we put it, some non‐linguistic items have ‘logical form’. The crucial examples are arguments, both deductive and inductive, made with unembedded words and phrases.
… subsentential expressions such as singular terms and predicates… cannot serve as premises or conclusions in inferences (R. Brandom, 2000, p. 40).
The antiphasic regulatory module comprising CDF5 and its antisense RNA FLORE links the circadian clock to photoperiodic flowering
Authors: Henriques Rossana , Wang Huan , Liu Jun , Boix Marc , Huang Li‐Fang , Chua Nam‐Hai 
Published: July 2017

Summary

Circadian rhythms of gene expression are generated by the combinatorial action of transcriptional and translational feedback loops as well as chromatin remodelling events. Recently, long noncoding RNAs (lncRNAs) that are natural antisense transcripts (NATs) to transcripts encoding central oscillator components were proposed as modulators of core clock function in mammals (Per) and fungi (frq/qrf). Although oscillating lncRNAs exist in plants, their functional characterization is at an initial stage.

By screening an Arabidopsis thaliana lncRNA custom‐made array we identified CDF5 LONG NONCODING RNA (FLORE), a circadian‐regulated lncRNA that is a NAT of CDF5. Quantitative real‐time RT‐PCR confirmed the circadian regulation of FLORE, whereas GUS‐staining and flowering time evaluation were used to determine its biological function.

FLORE and CDF5 antiphasic expression reflects mutual inhibition in a similar way to frq/qrf. Moreover, whereas the CDF5 protein delays flowering by directly repressing FT transcription, FLORE promotes it by repressing several CDFs (CDF1, CDF3, CDF5) and increasing FT transcript levels, indicating both cis and trans function.

We propose that the CDF5/FLORE NAT pair constitutes an additional circadian regulatory module with conserved (mutual inhibition) and unique (function in trans) features, able to fine‐tune its own circadian oscillation, and consequently, adjust the onset of flowering to favourable environmental conditions.
Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later
Authors: Hajishengallis George , Korostoff Jonathan M. 
Published: July 2017

AbstractIn their classic 1976 paper, Page & Schroeder described the histopathologic events and the types of myeloid cells and lymphocytes involved in the initiation and progression of inflammatory periodontal disease. The staging of periodontal disease pathogenesis as ‘initial’, ‘early’, ‘established’ and ‘advanced’ lesions productively guided subsequent research in the field and remains fundamentally valid. However, major advances regarding the cellular and molecular mechanisms underlying the induction, regulation and effector functions of immune and inflammatory responses necessitate a reassessment of their work and its integration with emerging new concepts. We now know that each type of leukocyte is actually represented by functionally distinct subsets with different, or even conflicting, roles in immunity and inflammation. Unexpectedly, neutrophils, traditionally regarded as merely antimicrobial effectors in acute conditions and protagonists of the ‘initial’ lesion, are currently appreciated for their functional versatility and critical roles in chronic inflammation. Moreover, an entirely new field of study, osteoimmunology, has emerged and sheds light on the impact of immunoinflammatory events on the skeletal system. These developments and the molecular dissection of crosstalk interactions between innate and adaptive leukocytes, as well as between the immune system and local homeostatic mechanisms, offer a more nuanced understanding of the host response in periodontitis, with profound implications for treatment. At the same time, deeper insights have generated new questions, many of which remain unanswered. In this review, 40 years after Page & Schroeder proposed their model, we summarize enduring and emerging advances in periodontal disease pathogenesis.
A Critical Perspective on Evidence‐Based Policy Making
Authors: Larson Samantha J. 
Published: July 2017

Related Content: Balfour (PAR September/October 2017)Related Content: Agranoff (PAR September/October 2017)Related Content: Mullendore (PAR September/October 2017)Related Content: Choi and Hoffman (PAR September/October 2017)Related Content: Khan (PAR September/October 2017)Related Content: Demircioglu (PAR September/October 2017)
An Ecological Investigation of the Emotional Context Surrounding Nonsuicidal Self‐Injurious Thoughts and Behaviors in Adolescents and Young Adults
Authors: Kranzler Amy , Fehling Kara B. , Lindqvist Janne , Brillante Julia , Yuan Fengpeng , Gao Xianyi , Miller Alec L. , Selby Edward A. 
Published: July 2017

Ecological momentary assessment (EMA) methodology was used to examine the emotional context of nonsuicidal self‐injury (NSSI). Forty‐seven adolescents and young adults used a novel smartphone app to monitor their emotional experiences, NSSI thoughts, and NSSI behaviors for 2 weeks. Momentary changes in both negative and positive emotions predicted greater intensity of NSSI thoughts at the subsequent assessment, while only increases in negative emotion predicted NSSI behaviors. Immediately following NSSI behaviors participants reported reduced high‐arousal negative emotions and increased low‐arousal positive emotions, suggesting that NSSI may be an efficient and effective method of regulating emotion. Findings highlight the importance of addressing emotion regulation in NSSI interventions.
Cytomegalovirus viral load in cord blood and impact of congenital infection on markers of hematopoietic progenitor cell potency
Authors: Albano M. Susana , Ciubotariu Rodica , Dobrila Ludy , Tarnawski Michal , DeLeon Margely , Watanabe Chiseko , Krishnan Siddarth , Scaradavou Andromachi , Rubinstein Pablo 
Published: July 2017

BACKGROUNDThe low incidence of cytomegalovirus (CMV) infection in neonates decreases the risk of viral transmission with cord blood transplantation. Cord blood donors are screened by testing the maternal sample for total antibodies to CMV. Some cord blood banks also screen cord blood for CMV‐DNA. The aim of this study was to develop and validate a multiplex real‐time polymerase chain reaction assay to measure CMV viral load in cord blood from asymptomatic infants with congenital CMV infection and to assess the impact of CMV infection on cord blood hematopoietic progenitor cell concentrations and colony‐forming unit functionality.STUDY DESIGN AND METHODSCMV infection was evaluated in two groups of cord blood donors: 1) 30,308 neonates prospectively screened by saliva culture, including 41 positive cases (0.14%), all from mothers with total antibodies to CMV; and 2) 4712 newborns from mothers with total antibodies to CMV who were screened retrospectively by polymerase chain reaction, including 18 positive cases (0.38%). All 59 infants with CMV were asymptomatic at birth.RESULTSAmong the 59 positive cases, the average CMV viral load in cord blood was 20.6 × 104 viral copies (vc)/mL; seven of 59 mothers (12%) had CMV‐DNA detected, however, with no association to their newborns' CMV viral load. Levels of colony‐forming units, CD34+/CD45+ cells, and total nucleated cells measured in a cohort of CMV‐positive cord blood samples were higher than those in the matched control group.CONCLUSIONWe developed and validated a multiplex real‐time polymerase chain reaction assay to detect CMV‐DNA in cord blood. In our study, maternal total antibodies to CMV or CMV‐DNA at birth were poor predictors of infection in cord blood donors. Furthermore, our results suggest that CMV congenital infection impacts CD34+/CD45+ cells and some hematopoietic progenitor cells toward higher proliferation.
Does the computed tomographic appearance of the lung differ between young and old dogs?
Authors: Hornby Natasha L. , Lamb Christopher R. 
Published: July 2017

AbstractIn computed tomographic (CT) images of humans, decreased lung attenuation, bronchial dilation, and/or thickening, air trapping, cysts, and thickened interlobular septa have been associated with increasing age. To determine if there are differences in the CT appearance of the lungs of young and old dogs that could affect interpretation of diagnostic studies, pulmonary CT images of dogs with conditions unrelated to the thorax were reviewed retrospectively in a case–control study. Computed tomography studies of 42 young dogs (range 0.3–4.8 years) and 47 old dogs (range 9–15.1 years) were jumbled and reviewed by an observer blinded to dog age. Computed tomography was performed under sedation in 62 (70%) dogs and under general anesthesia in 27 (30%). Heterotopic bone was more prevalent (62% vs. 14%) in old dogs. Lung collapse was significantly associated with old age, greater body weight, and anesthesia. There were no significant differences in median lung attenuation or occurrence of ground glass pattern, cysts, bronchial thickening, bronchial dilation, or degree of tracheal calcification. No examples of reticular pattern, emphysema, pleural thickening, or septal thickening were observed in any dog. Despite previous studies describing age‐related changes in the radiographic appearance of the lungs of old dogs, it appears that there are minimal observable differences in CT images. Old dogs are more likely to have visible foci of heterotopic bone and may be more prone to lung lobe collapse than young dogs, but neither of these differences should contribute to misdiagnosis of pulmonary disease.
Clinical and imaging findings, treatments, and outcomes in 27 dogs with imaging diagnosed trigeminal nerve sheath tumors: A multi‐center study
Authors: Swift Katie E. , McGrath Stephanie , Nolan Michael W. , Young Martin , Reese Michael , Rao Sangeeta , Randall Elissa , Leary Del , LaRue Susan 
Published: July 2017

AbstractThe clinical behavior of canine trigeminal nerve sheath tumors and benefits of previously reported treatments are incompletely defined. Aims of this retrospective, multicenter, observational study were to describe clinical signs, tumor localization characteristics, treatments, and clinical outcomes in a group of dogs with this neoplasm. Databases at four hospitals were reviewed for dogs with a trigeminal nerve sheath tumor diagnosis, magnetic resonance imaging (MRI) studies, and presentation between 2004 and 2014. A single observer recorded medical record findings and two observers recorded MRI characteristics by consensus. A total of 27 dogs met inclusion criteria (15 treated with stereotactic radiation therapy and 12 unirradiated). Two unirradiated dogs were excluded from outcome analyses. The most common presenting signs were masticatory muscle atrophy (26 dogs), neurologic signs referable to intracranial disease (13), and ocular disease (12). Based on MRI findings, all dogs had disease extending centrally at the level of the brainstem. The most commonly affected trigeminal nerve branches were the mandibular (26 dogs), maxillary (22), and ophthalmic (10). Of 15 dogs treated with stereotactic radiation therapy, one had improved muscle atrophy, and six had poor ocular health after treatment. Neurologic signs improved in 4/5 dogs with intracranial signs. Overall median survival time for the 10 unirradiated dogs with available follow‐up was 12 days and 441 days for the 15 stereotactic radiation therapy dogs. Mean survival times between these groups were not significantly different (mean 95% CI for unirradiated dogs was 44–424 days and mean 95% CI for stereotactic radiation therapy dogs was 260–518 days).
Reviewer Acknowledgements
Authors: Smith Robert 
Published: July 2017

Journal of Education and Training Studies (JETS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether JETS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue.Reviewers for Volume 5, Number 8António Calha, Polytechnic Institute of Portalegre, PortugalCarmen Pérez-Sabater, Universitat Poltècnica de València, SpainCélio Gonçalo Marques, Polytechnic Institute of Tomar, PortugalDeborah Christine Robinson, University of Derby, UKElena Jerves, University of Cuenca, EcuadorEnisa Mede, Bahcesehir University, TurkeyEsra DERELİ-Eskişehir Osmangazi University, TurkeyEsra DERELİ-Eskişehir Osmangazi University, TurkeyIntakhab Khan, King Abdulaziz University, Saudi ArabiaJohn Cowan, Edinburgh Napier University, UKLisa Marie Portugal, Grand Canyon University, USALorna T. Enerva, Polytechnic University of the Philippines, PhilippinesM. Emin Türkoğlu, Afyon Kocatepe University, TurkeyMarcie Zaharee, The MITRE Corporation, USAMeral Seker, Alanya Alaaddin Keykubat University, TurkeyMustafa Çakır, Marmara Üniversity, TurkeyNerina Fernanda Sarthou, Univ. Nacional del Centro de la Provincia de Buenos Aires, ArgentinaNicole Celestine, The University of Western Australia, AustraliaNiveen M. Zayed, MENA College of Management, JordanPirkko Siklander, University of Lapland, FinlandRichard Penny, University of Washington Bothell, USARui Manuel Carreteiro, National Institute of Psychology and Neurosciences, PortugalSamad Mirza Suzani, Islamic Azad University, IranSenem Seda Şahenk Erkan , Marmara University, TurkeySerkan Ünsal, K.Maraş Sütçü İmam University, TurkeyStamatis Papadakis, University of Crete, GreeceSuzan Kavanoz, Yıldız Technical University, TurkeyWang Kin Chiu, The Hong Kong Polytechnic University, Hong KongYakup Koç, Erzincan University, TurkeyYalçın Dilekli, Aksaray University, Turkey Robert SmithEditorial AssistantOn behalf of,The Editorial Board of Journal of Education and Training StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97008, USAURL: http://jets.redfame.com
SPATIOTEMPORAL TRANSMISSION DYNAMICS OF RECENT EBOLA OUTBREAK IN SIERRA LEONE, WEST AFRICA: IMPACT OF CONTROL MEASURES
Authors: ROY PARIMITA , UPADHYAY RANJIT KUMAR 
Published: July 2017

In this paper, we have formulated a compartmental epidemic model with exponentially decaying transmission rates to understand the Ebola transmission dynamics and study the impact of control measures to basic public health. The epidemic model exhibits two equilibria, namely, the disease-free and unique endemic equilibria. We have calculated the basic reproduction number through next generation matrix and investigated the spatial spread of the epidemic via reaction–diffusion modeling. Instead of fitting the model to the observed pattern of spread, we have used previously estimated parameter values and examined the efficacy of predictions of the designed model vis-à-vis the pattern of spread observed in Sierra Leone, West Africa. Further, we conducted a sensitivity analysis to determine the extent to which improvement in predictions is achievable through better parameterization.We performed numerical simulations with and without control measure for the designed model system. A significant reduction in infection and death cases were observed when proper control measures are incorporated in the model system. Two-dimensional simulation experiments show that infectious population and the number of deaths will increase up to one and a half years without control, but it will decline after two years. We have reported the numerical results, and it closely matches with the real situation in Sierra Leone.
A Web-Based Infrastructure for the Assisted Annotation of Heritage Collections
Authors: Foley Jacob , Kwan Paul , Welch Mitchell 
Published: July 2017

Annotations provide a valuable perspective on the semantic information present in digital heritage collections, and in recent years they've been employed in a number of innovative, user-centric techniques that can personalise a user's experience of heritage materials, such as by actively adapting exhibits as a user reveals their interests, or by guiding users to explore collections which are meaningfully linked to what they have previously encountered. Despite the captivating opportunities offered by these techniques, collecting annotations for a large heritage collection is no trivial task. A significant amount of work is required to manually annotate large quantities of heritage materials, and automated, computational approaches leave much to be desired regarding the level of insight and semantic richness that they can currently provide.
By analysing the emergent relationships between the initial annotations in a collection, we propose a metadata-driven algorithm for assisting and augmenting the annotation process. This algorithm, called SAGA (Semantically-Annotated Graph Analysis), allows for semi-automatic annotation, which balances the value of the contributions of human annotators with the time and effort-saving benefits of an automatic, suggestion-driven process. SAGA uses an entity relationship-driven approach to make annotation suggestions. It is used in the context of a web-based infrastructure called SAGE (Semantic Annotation by Group Exploration), a multiagent environment which assists groups of experts in creating comprehensive annotation sets for heritage collections. SAGA and SAGE are evaluated from the perspectives of suggestion accuracy, explicit user acceptance and implicit user acceptance, and demonstrate strong results in each evaluation.
Abstract 1003: Extranuclear ERα-mTOR signaling rewires cancer cell metabolism during obesity-associated breast cancer
Authors: Erdogan Zeynep Madak , Zhao Yiru C. , Rossi Gianluigi , Wrobel Kinga , Kulkoyluoglu Eylem , Kim Sung Hoon , Katzenellenbogen John A. , Flaws Jodi , Smith Rebecca 
Published: July 2017

Abstract
Obesity is a preventable risk factor for post-menopausal ERα-(+) breast cancer. We hypothesized that serum from obese post-menopausal women contain factors that would increase tumorigenicity of breast cancer cells and increase risk of ERα-(+) breast cancer. Using whole metabolite profiling and OLINK biomarker panel of about 400 proteins associated with cancer, inflammation and cardiovascular disease, we identified biomarkers that were differentially present in serum from 50 obese v.s. 50 non-obese postmenopausal women. Next, using in vitro cell based assays as proxy we identified certain free fatty acids (FFAs) as factors from serum that correlate with increased cell proliferation, motility and mTOR activation in ERα(+) breast cancer cells. We performed RNA-Seq, ERα ChIP-Seq and metabolomics analysis in breast cancer cells that are exposed to conditions that mimic serum from obese postmenopausal women. This integrative -omics approach enabled us to uncover ERα and mTOR pathway-dependent metabolic rewiring in breast cancer cells under these conditions. Pathway preferential estrogens (PaPEs), which target ERα and mTOR signaling, were able to block free fatty acid-dependent proliferation of breast cancer cells. In fact, efficient cancer cell killing by PaPEs was achieved only in the presence of FFAs, suggesting a role for obesity-associated metabolic rewiring in providing new vulnerabilities for the breast cancer cells. In summary, we uncovered a novel role for extranuclear-initiated ERα signaling in rewiring breast cancer cell metabolism in response to obesity-associated factors in the serum. Our findings provide a basis for preventing or inhibiting obesity-associated breast cancer by using PaPEs that would exploit new metabolic vulnerabilities of breast tumors in obese postmenopausal women.
Citation Format: Zeynep Madak Erdogan, Yiru C. Zhao, Gianluigi Rossi, Kinga Wrobel, Eylem Kulkoyluoglu, Sung Hoon Kim, John A. Katzenellenbogen, Jodi Flaws, Rebecca Smith. Extranuclear ERα-mTOR signaling rewires cancer cell metabolism during obesity-associated breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 1003. doi:10.1158/1538-7445.AM2017-1003