bluuebunny/crossref_metadata_2025_split huggingface dataset:
Myeloid-Derived Suppressor Cells Inhibit T Follicular Helper Cell Immune Response in Japanese Encephalitis Virus Infection
Authors: Wang Chong , Zhang Nan , Qi Luting , Yuan Jiaolong , Wang Ke , Wang Kunlun , Ma Sicong , Wang Haili , Lou Wenjuan , Hu Pingdong , Awais Muhammad , Cao Shengbo , Fu Zhen F. , Cui Min 
Published: October 2017

Abstract
Resolution of viral infections requires activation of innate cells to initiate and maintain adaptive immune responses. In this study, we examined Japanese encephalitis virus (JEV) infection leading to acute encephalopathy depending on suppression of the adaptive immune responses mediated by innate cells. Infection with P3 strains of JEV enhanced myeloid-derived suppressor cell (MDSC) populations, and the survival rate of JEV-infected mice improved after MDSC depletion. Mechanically, P3-induced MDSCs suppressed CD4+ T cell immune responses, especially responses of T follicular helper (Tfh) cells, leading to decreased splenic B cells (CD19+) and blood plasma cells (CD19+CD138+) and reduced levels of total IgM and JEV-specific neutralizing Abs. Upon depleting P3-induced MDSCs in vivo, the Tfh cell population, B cells, plasma cells, and Ab production recovered. These findings provide unique insights regarding MDSC functions in mediating immune suppression via inhibiting Tfh cell responses and further impairing humoral immunity, which facilitate the progression of infection.
NetMHCpan-4.0: Improved Peptide–MHC Class I Interaction Predictions Integrating Eluted Ligand and Peptide Binding Affinity Data
Authors: Jurtz Vanessa , Paul Sinu , Andreatta Massimo , Marcatili Paolo , Peters Bjoern , Nielsen Morten 
Published: October 2017

Abstract
Cytotoxic T cells are of central importance in the immune system’s response to disease. They recognize defective cells by binding to peptides presented on the cell surface by MHC class I molecules. Peptide binding to MHC molecules is the single most selective step in the Ag-presentation pathway. Therefore, in the quest for T cell epitopes, the prediction of peptide binding to MHC molecules has attracted widespread attention. In the past, predictors of peptide–MHC interactions have primarily been trained on binding affinity data. Recently, an increasing number of MHC-presented peptides identified by mass spectrometry have been reported containing information about peptide-processing steps in the presentation pathway and the length distribution of naturally presented peptides. In this article, we present NetMHCpan-4.0, a method trained on binding affinity and eluted ligand data leveraging the information from both data types. Large-scale benchmarking of the method demonstrates an increase in predictive performance compared with state-of-the-art methods when it comes to identification of naturally processed ligands, cancer neoantigens, and T cell epitopes.
Psychological Results of 438 Patients with persisting Gastroesophageal Reflux Disease Symptoms by Symptom Checklist 90-Revised Questionnaire
Authors: Chen Xia , Li Ping , Wang Fei , Ji Guozhong , Miao Lin , You Sihong 
Published: October 2017

ABSTRACT

Aims and objectives
Gastroesophageal reflux disease (GERD) affects mental state and social activities. On the contrary, mental disorders may also play a crucial role in GERD symptoms. The purpose of the study was to analyze the data of Symptom Checklist 90-Revised (SCL-90-R) questionnaire from patients with persisting GERD and to explore the impact of psychological factors on them.

Materials and methods
The patients accepted SCL-90-R questionnaire survey, following endoscopy, high-resolution manometry (HRM), and ambulatory impedance-pH monitoring. Based on these results, we divided patients into different groups. The result of SCL-90-R was also compared with degree of acid reflux, symptoms, symptom duration, and gender.

Results
The data from 438 patients were analyzed. All patients were divided into reflux esophagitis (RE; 63, 14.38%); nonerosive gastroesophageal reflux disease (NERD; 106, 24.20%); functional heartburn (FH; 123, 28.08%), hypersensitive esophagus (HE; 67, 15.29%), diffuse esophageal spasm (DES; 5: 1.14%), hypertensive (10, 3.42%); weak peristalsis (14, 3.20%); achalasia (50, 11.42%). There were significant differences between different groups regarding depression (DEP), anxiety (ANX), paranoid ideation (PAR), and psychoticism (PSY). The patients with ≥2 years with GERD presented with increased scores in DEP, ANX, and PSY. Women had dramatically higher scores than men in each domain (p < 0.05).

Conclusion
Data have shown that GERD patients exhibit differential levels of psychological symptoms. Long duration of GERD was related to typical plus atypical symptoms and females seem to be more prone to develop psychological disorders.

How to cite this article
Chen X, Li P, Wang F, Ji G, Miao L, You S. Psychological Results of 438 Patients with persisting Gastroesophageal Reflux Disease Symptoms by Symptom Checklist 90-Revised Questionnaire. Euroasian J Hepato-Gastroenterol 2017;7(2):117-121.
Hepatic Metastasis from Colorectal Cancer
Authors: Valderrama-Treviño Alan I , Barrera-Mera Baltazar , Ceballos-Villalva Jesús C , Montalvo-Javé Eduardo E 
Published: October 2017

ABSTRACT
The liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used.
In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs. Despite these improvements, the presence of metastasis, disease recurrence, and advanced local tumors continue to remain poor prognostic factors.
Median survival without treatment is <8 months from the moment of its presentation, and a survival rate at 5 years of 11% is the best prognosis for those who present with local metastasis. Even in patients with limited metastatic disease, 5-year survival is exceptional. Patients with hepatic metastasis of colorectal cancer have a median survival of 5 to 20 months with no treatment. Approximately 20 to 30% of patients with colorectal metastasis have disease confined to the liver, and this can be managed with surgery. Modern surgical strategies at the main hepatobiliary centers have proved that hepatectomy of 70% of the liver can be performed, with a mortality rate of <5%.
It is very important to have knowledge of predisposing factors, diagnostic methods, and treatment of hepatic metastasis. However, the establishment of newer, efficient, preventive screening programs for early diagnosis and adequate treatment is vital.

How to cite this article
Valderrama-Treviño AI, Barrera-Mera B, Ceballos-Villalva JC, Montalvo-Javé EE. Hepatic Metastasis from Colorectal Cancer. Euroasian J Hepato-Gastroenterol 2017;7(2):166-175.
Aneurysm of Portosystemic Fistula: A Case Report and Review of Literature
Authors: Ulus Sila , Akan Gulhan Ertan , Erol Cengiz 
Published: October 2017

ABSTRACTAimA case of asymptomatic aneurysm of spontaneous portosystemic venous fistula (SPVF) with the radiologic findings is described.BackgroundAlthough advances and more widespread use of ultrasound (US) and computed tomography angiography (CTA) have enabled more detection of SPVF in the liver, it is a rare entity.Case reportA 49-year-old male was referred to our hospital's nephrology outpatient clinic due to hypertension. Abdominal sonography examination detected a well-defined cystic lesion adjacent to the middle hepatic vein in the liver. The lesion showed venous flow in the color Doppler US examination. Computed tomography angiography examination revealed an aneurysm of the fistula.ConclusionRadiologists should be aware of this vascular anomaly and cyst-like lesions in the liver should be examined with color Doppler ultrasonography for possible vascularization, and be differentiated with CTA if necessary.Clinical significanceThis condition is usually encountered incidentally and patients usually have no symptoms. However, severe complications, such as hepatopulmonary syndrome, liver tumors, encephalopathy, and heart failure can be seen.How to cite this articleUlus S, Akan GE, Erol C. Aneurysm of Portosystemic Fistula: A Case Report and Review of Literature. Euroasian J Hepato-Gastroenterol 2017;7(2):178-180.
Long Esophageal Stricture in a Brittle Diabetic
Authors: Pak Stella C , Alastal Yaseen , Darr Umar , Yoon Youngsook 
Published: October 2017

ABSTRACT

Aim
We report a case of atypical esophageal stricture in a young diabetic woman.

Background
Diabetes mellitus and gastroesophageal reflux disease (GERD) are two common disorders in modern society.

Case report
A young diabetic woman developed a 6-cm-long esophageal stricture. This stricture was refractory to multiple esophageal dilation procedures. She underwent subtotal esophagectomy and had excellent treatment outcome.

Conclusion
Gastroesophageal reflux disease can cause severe long esophageal stricture in a brittle diabetic.

Clinical significance
Improving the awareness of their association between diabetes and GERD would greatly benefit the day-to-day practice of medicine.

How to cite this article
Pak SC, Darr U, Alastal Y, Yoon Y. Long Esophageal Stricture in a Brittle Diabetic. Euroasian J Hepato-Gastroenterol 2017;7(2):191-192.
Work Disability Prevention: A Primer for Occupational Therapists
Authors: McDougall Alicia , Nowrouzi-Kia Behdin 
Published: October 2017

Abstract
An estimated 313 million workplace accidents resulting in injury occur worldwide every year. Therefore, the burden of workplace injury and disability is present at the individual and the societal level and involves several stakeholders. There has been a shift in paradigm from workplace disability and injury treatment to workplace disability prevention. Occupational therapy practitioners are well positioned to address this multifaceted societal issue. Opening communication lines among stakeholders allows for a more holistic, collaborative, and comprehensive approach to disability, injury, and pain management. The positive results researchers have found at the individual level when using a holistic approach translate to benefits for all of the stakeholders involved. Occupational therapy practitioners may espouse a work disability prevention approach to reduce work disability rates and provide timely return-to-work outcomes for clients. The transition to the preventative model requires collaboration among stakeholders but would be beneficial to all stakeholders involved in the workplace.
The effects of meteorological parameters and diffusive barrier reuse on the sampling rate of a passive air sampler for gaseous mercury
Authors: McLagan David S. , Mitchell Carl P. J. , Huang Haiyong , Abdul Hussain Batual , Lei Ying Duan , Wania Frank 
Published: October 2017

Abstract. Passive air sampling of gaseous mercury (Hg) requires a high level of accuracy to discriminate small differences in atmospheric concentrations. Meteorological parameters have the potential to decrease this accuracy by impacting the sampling rate (SR), i.e., the volume of air that is effectively stripped of gaseous mercury per unit of time. We measured the SR of a recently calibrated passive air sampler for gaseous Hg in the laboratory under varying wind speeds (wind still to 6 m s−1), temperatures (−15 to +35 °C), and relative humidities (44 to 80 %). While relative humidity has no impact on SR, SR increases slightly with both wind speed (0.003 m3 day−1 increase in SR or 2.5 % of the previously calibrated SR for every m s−1 increase for wind speeds  > 1 m s−1, typical of outdoor deployments) and temperature (0.001 m3 day−1 increase in SR or 0.7 % for every 1 °C increase). The temperature dependence can be fully explained by the effect of temperature on the molecular diffusivity of gaseous mercury in air. Although these effects are relatively small, accuracy can be improved by adjusting SRs using measured or estimated temperature and wind speed data at or near sampling sites. We also assessed the possibility of reusing Radiello® diffusive barriers previously used in the passive air samplers. The mean rate of gaseous Hg uptake was not significantly different between new and previously used diffusive barriers in both lab and outdoor deployments, irrespective of the applied cleaning procedure. No memory effect from Radiellos® previously deployed in a high Hg atmosphere was observed. However, a loss in replicate precision for the dirtiest Radiellos® in the indoor experiment suggests that cleaning is advisable prior to reuse.
Les enseignants français du primaire face aux politiques de reddition de comptes : une évolution de leur professionnalisme dans un contexte d’accountability subjective
Authors: Dutercq Yves , Maleyrot Eric 
Published: October 2017

Notre contribution porte sur la manière dont les enseignants français de l’école primaire publique réagissent aux politiques de performance et de responsabilisation qui se sont développées ces dernières années. Elle cherche à savoir dans quelle mesure leur professionnalisme s’en trouve redéfini. Dans une première partie, une analyse sociohistorique décrit l'évolution des mesures de responsabilisation à travers la succession des outils et de leurs objectifs mis en place pour l’aide individualisée à la réussite des élèves. Nous examinons alors comment la responsabilité attachée au professionnalisme traditionnel des enseignants est remodelée par ces nouveaux dispositifs, en prenant en compte l’autorégulation et la faible reddition dont ils font l’objet. Dans une seconde partie, nous nous centrons sur la réception par les enseignants de deux dispositifs récents. Le premier est un instrument externe de mesure des résultats des élèves, le second un dispositif de mise à disposition d’un enseignant supplémentaire dans des écoles accueillant un public défavorisé. A partir d’enquêtes réalisées antérieurement, notre analyse secondaire met en lumière à la fois les résistances et l’évolution des pratiques professionnelles que ces politiques de responsabilisation suscitent. Enfin, dans une troisième partie, nous questionnons le professionnalisme « interne » des enseignants au regard du professionnalisme « externe » attendu par l'institution. Dans une politique de responsabilisation à régulation « douce », les enseignants (ré)agissent dans un contexte que nous qualifions d’« accountability subjective », laissant apparaître deux formes de professionnalisme, l’un traditionnel, attaché à une autonomie pédagogique individuelle, l’autre à dimension collective, acceptant reddition de comptes.
James Baldwin, Lionel Trilling, American Studies, and the Freudian Tragic
Authors: Garcia Jay 
Published: October 2017

The intellectual connection between James Baldwin and Lionel Trilling, and the resonances
across their criticism, are more substantial than scholarly and biographical treatments
have disclosed. For Trilling, Baldwin’s writings were notable for their deviation from
most humanistic inquiry, which he considered insufficiently alert to the harms and
depredations of culture. Baldwin’s work became for Trilling a promising indication that
American criticism could be remade along the lines of a tragic conception of culture
deriving from Freud. This essay concentrates on a relevant but neglected dynamic in
American letters—the mid-twentieth-century tension between Freudian thought and American
humanistic inquiry evident in fields like American Studies—to explain the intellectual
coordinates within which Trilling developed an affinity for Baldwin’s work. The
essay concludes by suggesting that the twilight of Freud’s tragic conception of
culture, which figured centrally in the modernist critical environment in which
Baldwin and Trilling encountered one another, contributed to an estrangement whereby the
two came to be seen as unrelated and different kinds of critics, despite the consonance of
their critical idioms during the 1940s and 1950s.
A randomized control trial feasibility evaluation of anmHealth intervention for wheelchair skill training among middle-aged and older adults
Authors: Giesbrecht Edward M. , Miller William C. 
Published: October 2017

BackgroundProviding mobility skills training to manual wheelchair (MWC) users can have a positive impact on community participation, confidence and quality of life. Often such training is restricted or not provided at all because of the expense of, and limited access to, occupational and physical therapists before and after discharge. This is particularly true among middle-aged and older adults, who often have limited access to rehabilitation services and require more time to learn motor skills. A monitored MWC skills training home program, delivered using a computer tablet (mHealth), was developed as an alternative approach to service delivery. The purpose of this study was to evaluate the feasibility of implementing thismHealth MWC skills training program among middle-aged and older adults.MethodsA 2 × 2 factorial design randomized controlled trial (RCT) was used to compare themHealth intervention and control groups, with additional wheeling time as a second factor. Community-dwelling MWC users aged 55 and older, who had used their MWC for less than two years and propelled with two hands, were recruited. Feasibility outcomes related to process, resources, management and treatment criteria were collected.ResultsEighteen participants were recruited, with a retention rate of 94%. Mean (±SD) duration for the first and second in-person training sessions were 90.1 ± 20.5 and 62.1 ± 5.5 min, respectively. In the treatment group, 78% achieved the minimum amount of home training (i.e., 300 min) over four weeks and 56% achieved the preferred training threshold (i.e., 600 min). Trainers reported only seven minor protocol deviations. No tablets were lost or damaged and there was one incident of tablet malfunction. No injuries or adverse incidents were reported during data collection or training activities. Participants indicated 98% agreement on the post-treatment benefit questionnaire.DiscussionOverall, the study protocol enabled implementation of the intervention in a safe, efficient and acceptable manner. Participant recruitment proved to be challenging, particularly gaining access to individuals who might benefit. Resource issue demands were acceptable for administration of the intervention; data collection was more time-consuming than anticipated but could be reduced with minor revisions. Participant retention and home program treatment adherence was high; both participant and trainer burden was acceptable. Treatment group participants reported a positive experience and clinical benefits from training program. The findings suggest a full-scale RCT evaluating the clinical impact of the Enhancing Participation In the Community by improving Wheelchair Skills (EPIC Wheels) intervention is warranted, provided the recruitment issues are addressed through collaborative partnerships and active recruitment strategies.
Mechanisms of action andin vivoantibacterial efficacy assessment of five novel hybrid peptides derived from Indolicidin and Ranalexin againstStreptococcus pneumoniae
Authors: Jindal Hassan Mahmood , Zandi Keivan , Ong Kien Chai , Velayuthan Rukumani Devi , Rasid Sara Maisha , Samudi Raju Chandramathi , Sekaran Shamala Devi 
Published: October 2017

BackgroundAntimicrobial peptides (AMPs) are of great potential as novel antibiotics for the treatment of broad spectrum of pathogenic microorganisms including resistant bacteria. In this study, the mechanisms of action and the therapeutic efficacy of the hybrid peptides were examined.MethodsTEM, SEM and ATP efflux assay were used to evaluate the effect of hybrid peptides on the integrity of the pneumococcal cell wall/membrane. DNA retardation assay was assessed to measure the impact of hybrid peptides on the migration of genomic DNA through the agarose gel.In vitrosynergistic effect was checked using the chequerboard assay. ICR male mice were used to evaluate thein vivotoxicity and antibacterial activity of the hybrid peptides in a standalone form and in combination with ceftriaxone.ResultsThe results obtained from TEM and SEM indicated that the hybrid peptides caused significant morphological alterations inStreptococcus pneumoniaeand disrupting the integrity of the cell wall/membrane. The rapid release of ATP from pneumococcal cells after one hour of incubation proposing that the antibacterial action for the hybrid peptides is based on membrane permeabilization and damage. The DNA retardation assay revealed that at 62.5 µg/ml all the hybrid peptides were capable of binding and preventing the pneumococcal genomic DNA from migrating through the agarose gel.In vitrosynergy was observed when pneumococcal cells treated with combinations of hybrid peptides with each other and with conventional drugs erythromycin and ceftriaxone. Thein vivotherapeutic efficacy results revealed that the hybrid peptide RN7-IN8 at 20 mg/kg could improve the survival rate of pneumococcal bacteremia infected mice, as 50% of the infected mice survived up to seven days post-infection.In vivoantibacterial efficacy of the hybrid peptide RN7-IN8 was signficantly improved when combined with the standard antibiotic ceftriaxone at (20 mg/kg + 20 mg/kg) as 100% of the infected mice survived up to seven days post-infection.DiscussionOur results suggest that attacking and breaching the cell wall/membrane is most probably the principal mechanism for the hybrid peptides. In addition, the hybrid peptides could possess another mechanism of action by inhibiting intracellular functions such as DNA synthesis. AMPs could play a great role in combating antibiotic resistance as they can reduce the therapeutic concentrations of standard drugs.