bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distance is not everything in imaging genomics of functional networks: reply to a commentary onCorrelated gene expression supports synchronous activity in brain networks
Authors: Richiardi Jonas , Altmann Andre , Greicius Michael 
Published: May 2017

AbstractOur 2015 paper (Richiardi et al., 2015), showed that transcriptional similarity of gene expression level is higher than expected by chance within functional brain networks (defined by functional magnetic resonance imaging), a relationship that is driven by around 140 genes. These results were replicated in vivo in adolescents, where we showed that SNPs of these genes where associated above chance with in-vivo fMRI connectivity, and in the mouse, where mouse orthologs of our genes showed above-chance association with meso-scale axonal connectivity. This paper has received a commentary on biorXiv (Pantazatos and Li, 2016), making several claims about our results and methods, mainly pointing out that Euclidean distance explains our results (“…high within-network SF is entirely attributable to proximity and is unrelated to functional brain networks…”). Here we address these claims and their weaknesses, and show that our original results stand, contrary to the claims made in the commentary.
Disparity, Diversity, and Duplications in the Caryophyllales
Authors: Smith Stephen A. , Brown Joseph W. , Yang Ya , Bruenn Riva , Drummond Chloe P. , Brockington Samuel F. , Walker Joseph F. , Last Noah , Douglas Norman A. , Moore Michael J. 
Published: May 2017

SummaryThe role whole genome duplication (WGD) plays in the history of lineages is actively debated. WGDs have been associated with advantages including superior colonization, various adaptations, and increased effective population size. However, the lack of a comprehensive mapping of WGDs within a major plant clade has led to uncertainty regarding the potential association of WGDs and higher diversification rates.Using seven chloroplast and nuclear ribosomal genes, we constructed a phylogeny of 5,036 species of Caryophyllales, representing nearly half of the extant species. We phylogenetically mapped putative WGDs as identified from analyses on transcriptomic and genomic data and analyzed these in conjunction with shifts in climatic niche and lineage diversification rate.Thirteen putative WGDs and twenty-seven diversification shifts could be mapped onto the phylogeny. Of these, four WGDs were concurrent with diversification shifts, with other diversification shifts occurring at more recent nodes than WGDs. Five WGDs were associated with shifts to colder climatic niches.While we find that many diversification shifts occur after WGDs it is difficult to consider diversification and duplication to be tightly correlated. Our findings suggest that duplications may often occur along with shifts in either diversification rate, climatic niche, or rate of evolution.
A Migratory Divide in the Painted Bunting (Passerina ciris)
Authors: Battey C.J. , Linck Ethan B. , Epperly Kevin L. , French Cooper , Slager David L. , Sykes Paul W. , Klicka John 
Published: May 2017

AbstractDivergence in migratory behavior is a potential mechanism of lineage divergence in sympatric populations and a key life history trait used in the identification of demographically independent units for conservation purposes. In the Painted Bunting (Passerina ciris), a North American songbird, populations on the Atlantic coast and interior southern United States are known to be allopatric during the breeding season, but efforts to map connectivity with wintering ranges in Mexico, Florida, and the Caribbean have been largely inconclusive. Using genomic and morphological data from natural history specimens and banded birds, we found evidence of three genetically differentiated populations with distinct wintering ranges and molt-migration phenologies. In addition to confirming that the Atlantic coast population remains allopatric throughout the annual cycle, we identified an unexpected migratory divide within the interior breeding range. Populations breeding in the Lower Mississippi River Valley winter on the Yucatán Peninsula, and are parapatric with other interior populations that winter in mainland Mexico and Central America. Across the interior breeding range, genetic ancestry is also associated with variation in wing length; suggesting that selective pressures may be promoting morphological divergence in populations with different migration strategies.
Long-lasting contribution of dopamine in the nucleus accumbens core, but not dorsal lateral striatum, to sign-tracking
Authors: Fraser Kurt M. , Janak Patricia H. 
Published: May 2017

AbstractThe attribution of incentive salience to reward-paired cues is dependent on dopamine release in the nucleus accumbens core. These dopamine signals conform to traditional reward-prediction error signals and have been shown to diminish with time. Here we examined if the diminishing dopamine signal in the nucleus accumbens core has functional implications for the expression of sign-tracking, a Pavlovian conditioned response indicative of the attribution of incentive salience to reward-paired cues. Food-restricted male Sprague-Dawley rats were trained in a Pavlovian paradigm in which an insertable lever predicted delivery of food reward in a nearby food cup. After 7 or 14 training sessions, rats received infusions of saline, the dopamine antagonist flupenthixol (100 mM), or the GABA agonists baclofen and muscimol (0.5 mM baclofen/0.05 mM muscimol) into the nucleus accumbens core or the dorsal lateral striatum. Dopamine antagonism within the nucleus accumbens core attenuated sign-tracking, whereas reversible inactivation did not affect sign-tracking but increased non-specific food cup checking behaviors. Neither drug in the dorsal lateral striatum affected sign-tracking behavior. Critically, extended training did not alter these effects. Though extended experience with an incentive stimulus may reduce cue-evoked dopamine in the nucleus accumbens core, this does not alter the function of dopamine in this region to promote Pavlovian cue approach nor result in the recruitment of dorsal lateral striatal systems for this behavior. These data support the notion that dopamine within the mesoaccumbal system, but not the nigrostriatal system, contributes critically to incentive motivational processes independent of the length of training.AbbreviationsDLSdorsal lateral striatumGTgoal-trackerINintermediate responderNAcCnucleus accumbens coreSTsign-tracker
Contribution of genetic variation and developmental stage to methylome dynamics in myeloid differentiation
Authors: Chen Xiang , Fan Yiping , Cheng Jinjun , Xu Beisi , Wang Yong-Dong , Yergeau Donald , Easton John , Downing James R. , Zhang Jinghui 
Published: May 2017

AbstractDNA methylation is important to establish a cell’s developmental identity. It also modulates cellular responses to endogenous developmental stimuli or environmental changes. We designed anin vitromyeloid differentiation model to analyze the genetic and developmental contribution to methylome dynamics using whole-genome bisulfide sequencing and transcriptome sequencing. Using a recursive partitioning approach, we identified 34,502 differentially methylated regions (DMRs) associated with genetic background and/or developmental stimuli. Specifically, 23,792 DMRs (69%) were significantly associated with inter-individual variations, of which 82% were associated with genetic polymorphisms incis. Notably, inter-individual variations further modified 57 of 212 (26%) developmental DMRs with transcriptomic responses. Our study presents a novel analytical approach to determine the bona fide genetic contribution embedded in outlier patterns of CpG-SNPs in individual methylomes. This approach can be used to study genetic and epigenetic mechanisms underlying differential responses to developmental stimuli, environmental changes, and inter-individual differences in drug responses.
Teens as impulsive buyers: what is the role of price?
Authors: Muratore Isabelle 
Published: May 2017

Purpose
Considering that retailers view impulse buying as an important component of their business (around 75 per cent of the purchases are unplanned) and considering also that teens often do some shopping in autonomy and represent an important financial power, the purpose of this paper is to fill the lack of studies concerning adolescent consumers impulse shopping behaviours. This paper investigates the relationships between the positive (prestige sensitivity, price quality schema) and the negative (price consciousness, value consciousness, price mavenism, sales proneness) role of price in teens’ impulse buyings.

Design/methodology/approach
The test of the hypotheses has been achieved on a sample of 325 French teens (age between 14 and 18) using MANOVA. Previously, respondents were split in two groups which are impulsive buyers and non-impulsive buyers.

Findings
Findings show clearly differences between teens’ impulsive buyings and teens’ non-impulsive buyings. Teens’ as impulsive buyers possess more prestige sensitivity, price-quality schema, price mavenism, sale proneness and less price consciousness and value consciousness than non-impulsive buyers. Moreover, females adolescents are more inclined to be impulsive buyers than males adolescents.

Originality/value
Not only it is one of the rare studies that investigates on teens’ impulsive buying but above all, it is the only study that takes into consideration the role of price perception, while a price has to be paid in order to buy.
A resource dependency framework for innovation and internationalization of family businesses
Authors: Singh Ramanjeet , Kota Hima Bindu 
Published: May 2017

PurposeTo compete and to survive in this era of globalization, organizations, including family businesses, need to have competitive advantage, and innovation and internationalization are some of the ways to achieve this. This paper aims to analyze whether family businesses innovate and internationalize more than non-family businesses and further analyses the type of family businesses “age-wise” and “size-wise” that innovate and internationalize more.Design/methodology/approachThe study is empirical in nature. The period of study is 11 years, from 2005 to 2015 (both years inclusive). The sample is chosen from Bombay Stock Exchange (BSE) 500 index, a broad-based index in India, covering about 20 industries of the economy. The present study uses multiple regression models to find the innovativeness and internationalization of family businesses. The dependent variables are R&D (proxy for innovativeness) and FXINC (proxy for internationalization). The independent variables are FB (variable that defines whether a business is family business or non-family business); FBAGE (variable that defines the age of the family business); and FBSIZE (variable that defines the size of the family business). The other control variables used in in the study are TA (total assets), REV (revenue), CR (current ratio), QR (quick ratio), DER (debt-equity ratio) and RONW (return on net worth). Fixed effects model was used to understand the innovativeness and internationalization of family businesses. Both industry and year fixed effects were used. SPSS 20.0 version is used for the analysis. All results are heteroscedastic consistent using Breusch–Pagan test.FindingsIt is found that family businesses are more innovative and internationalized when compared to non-family businesses. The results are consistent with the resource-based theory where it is found that family businesses are entrepreneurial in nature (Salvato, 2004; Zahraet al., 2004; Kellermanns and Eddleston, 2006) which makes them more innovative. It was also found that within the family businesses, younger firms were more innovative and internationalized than older firms. This can be explained by the theory of “learning advantages of newness”, according to which younger firms are more flexible, eager to learn, have less internal resistance and are able to adapt to the changing environment much faster.Originality/valueDuring the studies, the authors have found that there is no conclusive evidence on the innovativeness and internationalization of family businesses. Further, there are apparently negligible studies that analyze what type of family businesses, age wise (younger or older firms) and size wise (smaller or larger firms) use the strategy of innovation and internationalization to grow. The present study analyses the innovativeness and internationalization of family businesses when compared to non-family businesses and also studies the type of family businesses (age wise and size wise) that are more innovative and internationalized.
Differences between firms from the formal sector and the informal sector in terms of growth
Authors: Abdallah Gorah Kassim 
Published: May 2017

Purpose
Small businesses growth has become an important area of study in the field of entrepreneurship. This paper aims to extend the inquiry by investigating whether there is a significant difference in growth between firms from the formal sector and the informal sector in the least developing countries (LDCs), particularly Tanzania.

Design/methodology/approach
A survey strategy as well as non-probability sampling are used. The sampling included 50 formal and 61 informal small businesses from the furniture industry. Data collected were evaluated using chi square and compounded annual growth rate (CAGR) techniques.

Findings
The results indicate that firms from the formal sector do not grow faster than firms from the informal sector. on the contrary, our tests reveal that firms from the informal sector predominantly grow faster than firms from the formal sector.

Research limitations/implications
The study was conducted in Tanzania which is just one of the 48 LDCs in the world. Second, the literature that is used predominantly applies to developed countries. Third, the field work dependent on the respondent’s perception. Finally, change of measurement scale from five to three is ought to have contributed to mixed findings.

Practical implications
The overall implications are that external factors like inadequate regulatory tax systems may affect growth of formal small businesses and thus influence market opportunities for informal small businesses. Further, internal factors like inefficiencies of workers from formal enterprises may affect growth and therefore create more opportunities for informal enterprises.

Originality/value
Exploring differences between firms from the formal sector and the informal sector, and the way five scales were aggregated into three scales in the methodology.
Strategic interventions to improve women entrepreneurship in GCC countries
Authors: Faisal Mohd. Nishat , Jabeen Fauzia , I. Katsioloudes Marios 
Published: May 2017

PurposeIn Gulf Cooperation Council (GCC) countries, entrepreneurship is not a very popular option among women. The low rate of entrepreneurship as a career choice among females is attributed to factors that are specific to females in GCC region. The purpose of this paper is to understand these variables and their interrelationships that lead to low rate of adoption of entrepreneurship as a career choice among females in GCC region.Design/methodology/approachThe research followed a two-stage process; first, a comprehensive literature review was conducted to identify barriers to female entrepreneurship in GCC region. In the second stage, the identified barriers were modeled using fuzzy interpretive structural modeling technique to construct a hierarchical structure and the impact matrix cross-reference multiplication applied to a classification approach to analyze the control power and dependence among these barriers.FindingsThe research shows that there exists a group of barriers having a high driving power and low dependence requiring maximum attention and of strategic importance, while another group consists of those variables that have high dependence and are the resultant actions.Practical implicationsThis research will help policy makers to focus on variables that are most important and requires immediate attention for the development and empowerment of female entrepreneurship in the GCC region. The paper suggests future course of action to provide an impetus to efforts aimed at improving female entrepreneurship in the GCC region.Originality/valueThe policy makers in the GCC region have accorded high priority to entrepreneurship to reduce the dependence of population on government jobs. This research is one of the few studies on female entrepreneurship conducted in GCC region to understand the impediments that limit the adoption of entrepreneurship as a career choice by women.
Towards an entrepreneurial theory of practice; emerging ideas for emerging economies
Authors: Anderson Alistair , Ronteau Sébastien 
Published: May 2017

PurposeThe purpose of this paper is to examine the explanatory power of existing theories of entrepreneurship. The authors find gaps and fragmentation and offer propose a different approach – a theory of entrepreneuring – a theory of practice.Design/methodology/approachThis is a conceptual paper, but the authors draw heavily on the literature. They also offer examples of what the theory can offer.FindingsExisting theory is good at explaining aspects of entrepreneurship. However, most theories are discipline bound and operate in silos. A theory of entrepreneurship practice can connect and bridge disciplines.Originality/valueA theory of entrepreneurship as practice will not replace current theories. It will however complement them and thus be well suited to emerging economies.
Contrasting the nature and effects of environmentally specific and general transformational leadership
Authors: Robertson Jennifer L. , Barling Julian 
Published: May 2017

PurposeThe purpose of this paper is to report findings from two studies that compare the nature (construct validity) and relative effects (incremental predictive validity) of environmentally specific transformational leadership (ETFL) to general transformational leadership.Design/methodology/approachThe nature of ETFL was investigated in an empirical study based on a sample of 185 employees. The relative effects of ETFL were examined in an experimental study based on a sample of 155 university students.FindingsA confirmatory factor analysis showed that environmentally specific and general transformational leadership are empirically distinct but related. Findings from the experimental study revealed that compared to general transformational leadership and a control condition, participants exposed to ETFL he confederate leader’s environmental values and priorities more highly and engaged in higher levels of pro-environmental behaviors.Research limitations/implicationsQuestions concerning ecological and external validity arise out of the experimental study. Future research should contrast the relative effects of environmentally specific and general transformational leadership across various organizational and cultural conditions. Limitations associated with demand characteristics are also of concern in the experimental study. Future research should include an environmental focus in the control condition to exclude any possible threats related to demand characteristics.Practical implicationsResults from these two studies provide useful information regarding within-organization environmental leadership training by suggesting that maximal individual and organizational environmental change may best be achieved by training leaders to be as specific as possible regarding their values, priorities and goals.Social implicationsThis research suggests that leaders should engage in ETFL behaviors to have the greatest positive impact on corporate environmental sustainability, and by extension, climate change.Originality/valueIn two separate studies, the construct and incremental predictive validity of ETFL were assessed.
Politicising dark tourism sites: evidence from Cyprus
Authors: Farmaki Anna , Antoniou Katerina 
Published: May 2017

Purpose
This paper aims to extend understanding on how the tourist experience at dark heritage sites is directed and consequently influences the narratives of cultural heritage. By discussing the way dark heritage sites are projected by suppliers, the paper anticipates to advance knowledge on the nexus between dark tourism and heritage and to offer insights into the management of dissonant heritage sites.

Design/methodology/approach
The cases of two opposing national museums in the divided island of Cyprus are presented and discussed in an attempt to illustrate how dissonant heritage interpretation in a post-conflict context is often the product of political direction, commemorating the past and to a great extent influencing the future of a society.

Findings
National struggle museums represent dark heritage sites, which evoke emotions pertinent to ethnic identity reinforcement. Evidently, the management of such sites is in opposition to peace-building efforts taking place in a post-conflict context. The paper concludes that visitation to dark heritage sites is culturally driven rather than death-related and suggests that efforts consolidate to target specific segments of visitors, if the reconciliation potential of dark tourism is to be unleashed.

Originality/value
Insofar, minimal attention has been paid on the conditions of the supply of dark heritage sites and the role of suppliers in influencing culture-based issues including collective memory and national identity. This paper addresses this gap in literature and advances understanding on the developmental elements defining dark heritage tourism, by identifying and discussing trajectories between dark tourism and politics.
Dark tourism sites: visualization, evidence and visitation
Authors: Lennon J. John 
Published: May 2017

Purpose
This paper aims to consider dark tourism sites and their pivotal role as evidence of atrocity and evil. How they are interpreted and the role of visual imagery, most particularly photography, are considered from the perspective of the locations as heritage and learning sites. The complex arguments in relation to conservation and maintenance are juxtaposed with the behaviour of visitors in recording and uploading imagery of such material. This phenomenon allows us to consider the enormity of witnessing such events and viewing such sites as part of contemporary tourist behaviour.

Design/methodology/approach
The approach utilizes contemporary literature from tourism, sociology and film studies and uses secondary sources to highlight key sites that illustrate discursive elements of the paper.

Findings
This appeal and appetite for photographic and filmic record by visitors to such dark sites illustrates not only an inherent fascination but also a series of dark and recurring themes. However, it is also notable that in some locations, ideological selectivity in development is present and evidence, record and history are challenged. The cases of Cambodia and Russia and elements of their tragic pasts are used to illustrate why key heritage sites are developed as attractions or are ignored as evidential sites. For these reasons, this area still merits evaluation and discussion in tourism.

Originality/value
The area of dark tourism has been the focus of researchers for over a decade. However, the areas of selectivity in development, ideological impact on content and the issues related to visualization have not as yet been fully explored. This paper begins to explore issues related to visualization and evidence and how it related to these dark tourism sites.