bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of CBCT‐based dose with a patient‐specific stepwise HU‐to‐density curve to determine time of replanning
Authors: Chen Shifeng , Le Quynh , Mutaf Yildirim , Lu Wei , Nichols Elizabeth M. , Yi Byong Yong , Leven Tish , Prado Karl L. , D'Souza Warren D. 
Published: July 2017

AbstractPurpose(a) To investigate the accuracy of cone‐beam computed tomography (CBCT)–derived dose distributions relative to fanbeam–based simulation CT‐derived dose distributions; and (b) to study the feasibility of CBCT dosimetry for guiding the appropriateness of replanning.Methods and materialsImage data corresponding to 40 patients (10 head and neck [HN], 10 lung, 10 pancreas, 10 pelvis) who underwent radiation therapy were randomly selected. Each patient had both intensity‐modulated radiation therapy and volumetric‐modulated arc therapy plans; these 80 plans were subsequently recomputed on the CBCT images using a patient‐specific stepwise curve (Hounsfield units‐to‐density). Planning target volumes (PTVs; D98%, D95%, D2%), mean dose, and V95% were compared between simulation‐CT–derived treatment plans and CBCT‐based plans. Gamma analyses were performed using criterion of 3%/3 mm for three dose zones (>90%, 70%~90%, and 30%~70% of maximum dose). CBCT‐derived doses were then used to evaluate the appropriateness of replanning decisions in 12 additional HN patients whose plans were previously revised during radiation therapy because of anatomic changes; replanning in these cases was guided by the conventional observed source‐to‐skin‐distance change‐derived approach.ResultsFor all disease sites, the difference in PTV mean dose was 0.1% ± 1.1%, D2% was 0.7% ± 0.1%, D95% was 0.2% ± 1.1%, D98% was 0.2% ± 1.0%, and V95% was 0.3% ± 0.8%; For 3D dose comparison, 99.0% ± 1.9%, 97.6% ± 4.4%, and 95.3% ± 6.0% of points passed the 3%/3 mm criterion of gamma analysis in high‐, medium‐, and low‐dose zones, respectively. The CBCT images achieved comparable dose distributions. In the 12 previously replanned 12 HN patients, CBCT‐based dose predicted well changes in PTV D2% (Pearson linear correlation coefficient = 0.93; P < 0.001). If 3% of change is used as the replanning criteria, 7/12 patients could avoid replanning.ConclusionsCBCT‐based dose calculations produced accuracy comparable to that of simulation CT. CBCT‐based dosimetry can guide the decision to replan during the course of treatment.
Timed Delivery of Therapy Enhances Functional Muscle Regeneration
Authors: Cezar Christine A. , Arany Praveen , Vermillion Sarah A. , Seo Bo Ri , Vandenburgh Herman H. , Mooney David J. 
Published: July 2017

AbstractCell transplantation is a promising therapeutic strategy for the treatment of traumatic muscle injury in humans. Previous investigations have typically focused on the identification of potent cell and growth factor treatments and optimization of spatial control over delivery. However, the optimal time point for cell transplantation remains unclear. Here, this study reports how myoblast and morphogen delivery timed to coincide with specific phases of the inflammatory response affects donor cell engraftment and the functional repair of severely injured muscle. Delivery of a biomaterial‐based therapy timed with the peak of injury‐induced inflammation leads to potent early and long‐term regenerative benefits. Diminished inflammation and fibrosis, enhanced angiogenesis, and increased cell engraftment are seen during the acute stage following optimally timed treatment. Over the long term, treatment during peak inflammation leads to enhanced functional regeneration, as indicated by reduced chronic inflammation and fibrosis along with increased tissue perfusion and muscle contractile force. Treatments initiated immediately after injury or after inflammation had largely resolved provided more limited benefits. These results demonstrate the importance of appropriately timing the delivery of biologic therapy in the context of muscle regeneration. Biomaterial‐based timed delivery can likely be applied to other tissues and is of potential wide utility in regenerative medicine.
Fluoreszenzsonden mit mehreren Bindungsstellen unterscheiden zwischen Cys, Hcy und GSH
Authors: Yin Cai‐Xia , Xiong Kang‐Ming , Huo Fang‐Jun , Salamanca James C. , Strongin Robert M. 
Published: July 2017

AbstractThiole wie Cystein (Cys), Homocystein (Hcy) und Glutathion (GSH) spielen für das Redoxgleichgewicht in biologischen Systemen eine entscheidende Rolle. Dieser Kurzaufsatz fasst aktuelle Aspekte aus dem Bereich der reaktiven Thiolsonden für die biomedizinische Forschung und Diagnostik zusammen und betont die verbleibenden Herausforderungen für Chemiker im Bereich der selektiven Sonden und Sensoren. Der Fortschritt bei Sonden mit mehreren Bindungsstellen stellt eine kreative neue Richtung des Feldes dar, die gleichzeitige und akkurate ratiometrische Messungen ermöglichen kann. Neue Strategien zur Entwicklung von Sonden können helfen, aktuelle Aufgaben anzugehen. Dazu zählt das Monitoring von Krankheiten, die durch abweichende GSH‐, Cys‐ und Hcy‐Spiegel gekennzeichnet sind, wie etwa Autismus und chronische Erkrankungen, die auf oxidativem Stress beruhen.
Stoichiometric and Catalytic C−C and C−H Bond Formation with B(C6F5)3 via Cationic Intermediates
Authors: Soltani Yashar , Wilkins Lewis C. , Melen Rebecca L. 
Published: July 2017

AbstractThis work showcases a new catalytic cyclization reaction using a highly Lewis acidic borane with concomitant C−H or C−C bond formation. The activation of alkyne‐containing substrates with B(C6F5)3 enabled the first catalytic intramolecular cyclizations of carboxylic acid substrates using this Lewis acid. In addition, intramolecular cyclizations of esters enable C−C bond formation as catalytic B(C6F5)3 can be used to effect formal 1,5‐alkyl migrations from the ester functional groups to unsaturated carbon–carbon frameworks. This metal‐free method was used for the catalytic formation of complex dihydropyrones and isocoumarins in very good yields under relatively mild conditions with excellent atom efficiency.
Influence of reversion in compounds containing recycled natural rubber: In search of sustainable processing
Authors: de Sousa Fabiula D. B. , Zanchet Aline , Scuracchio Carlos H. 
Published: July 2017

ABSTRACTThe influence of rubber devulcanization by microwaves in the reversion behavior is still modestly explored in the literature. The reversion occurs due to thermal degradation of unstable crosslinkings formed during the vulcanization process. This phenomenon results in poor final mechanical properties of the artifacts. In this work, some formulations based on natural rubber (NR) with the incorporation of NR devulcanized by microwaves at different exposure times to the microwaves were vulcanized by compression molding at the same temperature and time used for the study of their vulcanization characteristics, in order to correlate the properties obtained and understand the influence of the reversion on the mechanical properties. The results showed that levels of devulcanization/degradation of the recycled phase, as well as the additional heating time influenced on the behavior of reversion and, consequently, on the mechanical properties. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45325.
Electrical properties of flexible graphene reinforced polyimide composites
Authors: Marashdeh Wajeeh , Iroh Jude O. 
Published: July 2017

ABSTRACTThe electrical properties of polyimide and the composite at different volumes fractions were studied in the frequency range 200–20 kHz and in the temperature range 30–200 °C. Increasing the volume fraction of graphene up to 10%, resulted in an extremely large increase in the dielectric constant, which indicates the composites remarkable ability to store electric potential energy under the effect of alternating electric field. An increase in dielectric constant was also observed with increasing temperature and decreasing frequency. The outstanding dielectric properties of polyimide graphene nanocomposites are attributed to the large volume fraction of interfaces in the bulk of the material. The measured increase in dielectric constant with increasing temperature was attributed to the segmental mobility of the polymer chains. The AC conductivity for polyimide and the composites was calculated from the loss factor and a remarkably high conductivity was obtained for the composites due to the formation of conducting paths in the matrix by the graphene sheets. Also this study showed that the thermal conductivity of the composites increased sharply with increasing graphene concentration. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45372.
Fabrication and SERS application of the thermoresponsive nanofibers with monodisperse Au@Ag bimetallic nanorods loaded shells
Authors: Chen Siyuan , Liu Xiaoyun , Zhou Jianfeng , Zha Liusheng 
Published: July 2017

ABSTRACTMonodisperse Au@Ag bimetallic nanorods (Au@AgNRs) with gold nanorod core and silver shell were introduced into the shells of the thermoresponsive nanofibers with core‐shell structure by coaxial electrospinning technique using poly(N‐isopropylacrylamide‐co‐N‐hydroxymethylacrylamide) aqueous solution as core fluid and its Au@AgNRs mixture as shell fluid, followed by heat treatment. Their core‐shell structure and the oriented alignment of the Au@AgNRs embedded within their shells along their axes were confirmed by transmission electron microscopy observation. The produced composite nanofibrous membrane has high stability in aqueous medium and more remarkable and faster thermoresponsiveness than our previously reported composite nanofibrous membrane with homogeneous Au@AgNRs distribution inside its constituent nanofibers. The smart composite nanofibrous membrane as a free‐standing surface enhanced Raman spectroscopy substrate with temperature‐dependent surface enhanced Raman spectroscopy efficiency from 25 to 50 °C and good reproducibility is able to be used to detect 10−14 mol/L 4‐mercaptobenzoic acid in aqueous solution at 50 °C. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45375.
Oxidation‐grafting surface modification of waste silicone rubber composite insulator powder: Characterizations and properties of EPDM/modified waste powder composites
Authors: Sun Bin , Du Zhenxia , Cao Hongwei , Du Linjuan , Yu Wenlian 
Published: July 2017

ABSTRACTIn order to broaden the applications of waste silicone rubber composite insulator powder (WSP), modified waste powder (WSP‐KH570) was prepared by a two‐step treatment process involving improved surface oxidation approach by using acidic H2O2 solution and subsequently grafting of KH570. Fourier transform infrared spectroscopy in the attenuated total reflection mode (FTIR‐ATR) analysis revealed the presence of KH570 on the powder surface. The result was confirmed by thermogravimetric analysis (TGA). Blends of ethylene propylene diene monomer (EPDM) with WSP‐KH570 were prepared. The effects of WSP‐KH570 on mechanical properties and thermal properties of the blends were investigated. The WSP‐KH570 showed an observed improvement in tensile strength and elongation at break of EPDM/WSP‐KH570 blends compared with corresponding compositions of EPDM/WSP blends. The TGA cure showed that EPDM filled with WSP‐KH570 had higher thermal stability at 210–380 °C than EPDM/WSP. Dynamic mechanical analysis indicated EPDM and WSP‐KH570 were better miscible with the blend ratio (90/10). © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45438.
Modelling functional fish habitat connectivity in rivers: A case study for prioritizing restoration actions targeting brown trout
Authors: Roy Mathieu L. , Le Pichon Céline 
Published: July 2017

Abstract

Throughout the world, decreased connectivity of fluvial habitats caused by artificial river channel alterations such as culverts, weirs and dykes is seen as an important threat to the long‐term survival of many aquatic species. In addition to assessing habitat quality and abundance, wildlife managers are becoming increasingly aware of the importance of taking into account habitat connectivity when setting priorities for restoration. In this paper, a new approach of spatial analysis adapted to rivers and streams is proposed for modelling 2D functional habitat connectivity, integrating distance, costs and risk of travelling between habitat patches (e.g. daily use, spawning, refuge) for particular fish species, size classes and life stages.
This approach was applied to a case study in which brown trout (Salmo trutta) habitat accessibility was examined and compared under various scenarios of stream restoration in a highly fragmented stream in Ile‐de‐France. Probabilities of reaching spawning habitats were estimated from a trout‐populated area located downstream of the barriers and from potential daily‐use habitat patches across the stream segment.
The approach successfully helped prioritize restoration actions by identifying options that yield the greatest increase in accessible spawning habitat areas and connectivity between spawning habitat and daily‐use habitat patches. This case study illustrates the practical use of the approach and the software in the context of river habitat management.
Quantifying the extremity of windstorms for regions featuring infrequent events
Authors: Walz Michael A. , Kruschke Tim , Rust Henning W. , Ulbrich Uwe , Leckebusch Gregor C. 
Published: July 2017

AbstractThis paper introduces the Distribution‐Independent Storm Severity Index (DI‐SSI). The DI‐SSI represents an approach to quantify the severity of exceptional surface wind speeds of large scale windstorms that is complementary to the SSI introduced by Leckebusch et al. While the SSI approaches the extremeness of a storm from a meteorological and potential loss (impact) perspective, the DI‐SSI defines the severity in a more climatological perspective. The idea is to assign equal index values to wind speeds of the same singularity (e.g. the 99th percentile) under consideration of the shape of the tail of the local wind speed climatology. Especially in regions at the edge of the classical storm track, the DI‐SSI shows more equitable severity estimates, e.g. for the extra‐tropical cyclone Klaus. In order to compare the indices, their relation with the North Atlantic Oscillation is studied, which is one of the main large scale drivers for the intensity of European windstorms.
Efficient Long‐Range Hole Transport Through G‐Quadruplexes
Authors: Wu Jingyuan , Meng Zhenyu , Lu Yunpeng , Shao Fangwei 
Published: July 2017

AbstractDNA offers a means of long‐range charge transport for biology and electric nanodevices. Here, a series of tetra‐stranded G‐quadruplexes were assembled within a dendritic DNA architecture to explore oxidative charge transport (hole transport) through the G‐quadruplex. Efficient charge transport was achieved over 28 Å upon UV irradiation. Over a longer G‐quadruplex bridge, hole transport was escalated to a higher efficiency, which resulted in a higher yield than that of the optimal duplex DNA for charge transport, that is, the adenine tract. Efficient long‐range hole transport suggests tetra‐stranded G‐quadruplexes, instead of an oxidation hotspot, hold better potential as an electron conduit than duplex DNA.
Approach Matters: The Kinetics of Interfacial Inverse‐Electron Demand Diels–Alder Reactions
Authors: Sen Rickdeb , Gahtory Digvijay , Escorihuela Jorge , Firet Judith , Pujari Sidharam P. , Zuilhof Han 
Published: July 2017

AbstractRapid and quantitative click functionalization of surfaces remains an interesting challenge in surface chemistry. In this regard, inverse electron demand Diels–Alder (IEDDA) reactions represent a promising metal‐free candidate. Herein, we reveal quantitative surface functionalization within 15 min. Furthermore, we report the comprehensive effects of substrate stereochemistry, surrounding microenvironment and substrate order on the reaction kinetics as obtained by surface‐bound mass spectrometry (DART‐HRMS).
Efficient Electron Transfer across a ZnO–MoS2–Reduced Graphene Oxide Heterojunction for Enhanced Sunlight‐Driven Photocatalytic Hydrogen Evolution
Authors: Kumar Suneel , Reddy Nagappagari Lakshmana , Kushwaha Himmat Singh , Kumar Ashish , Shankar Muthukonda Venkatakrishnan , Bhattacharyya Kaustava , Halder Aditi , Krishnan Venkata 
Published: July 2017

AbstractThe development of noble metal‐free catalysts for hydrogen evolution is required for energy applications. In this regard, ternary heterojunction nanocomposites consisting of ZnO nanoparticles anchored on MoS2–RGO (RGO=reduced graphene oxide) nanosheets as heterogeneous catalysts show highly efficient photocatalytic H2 evolution. In the photocatalytic process, the catalyst dispersed in an electrolytic solution (S2− and SO32− ions) exhibits an enhanced rate of H2 evolution, and optimization experiments reveal that ZnO with 4.0 wt % of MoS2–RGO nanosheets gives the highest photocatalytic H2 production of 28.616 mmol h−1 gcat−1 under sunlight irradiation; approximately 56 times higher than that on bare ZnO and several times higher than those of other ternary photocatalysts. The superior catalytic activity can be attributed to the in situ generation of ZnS, which leads to improved interfacial charge transfer to the MoS2 cocatalyst and RGO, which has plenty of active sites available for photocatalytic reactions. Recycling experiments also proved the stability of the optimized photocatalyst. In addition, the ternary nanocomposite displayed multifunctional properties for hydrogen evolution activity under electrocatalytic and photoelectrocatalytic conditions owing to the high electrode–electrolyte contact area. Thus, the present work provides very useful insights for the development of inexpensive, multifunctional catalysts without noble metal loading to achieve a high rate of H2 generation.
An effective approach to solving large communication overhead issue and strengthening the securities of AKA protocols
Authors: Chien Hung‐Yu 
Published: July 2017

SummaryAuthentication and key agreement (AKA) is a challenge‐response‐like security protocol that uses symmetric‐key cryptography to establish authenticated keys between 2 parties. Its application in the third‐generation mobile system universal mobile telecommunications system (UMTS) is called UMTS‐AKA, and the version applied in the fourth‐generation mobile communication system long‐term evolution (LTE) is called LTE‐AKA. Both UMTS‐AKA and LTE‐AKA share the same weakness: the network operators need to maintain a large space of authentication vectors for visiting stations, and the transmission of the vectors causes lots of overhead. This weakness will be amplified when there are billions of devices accessing the network in the Internet‐of‐things scenarios. In addition, these schemes provide only key distribution (not key agreement) and cannot provide session key forward secrecy. In this paper, we propose a range‐bound key assignment technique to tackle the challenges. The proposed scheme drastically reduces the communication overhead and greatly strengthens the security robustness. The securities are analyzed and are verified using the AVISPA toolset.
Nonlinear FE model updating and reconstruction of the response of an instrumented seismic isolated bridge to the 2010 Maule Chile earthquake
Authors: Li Yong , Astroza Rodrigo , Conte Joel P. , Soto Pedro 
Published: July 2017

SummaryNonlinear finite element (FE) modeling has been widely used to investigate the effects of seismic isolation on the response of bridges to earthquakes. However, most FE models of seismic isolated bridges (SIB) have used seismic isolator models calibrated from component test data, while the prediction accuracy of nonlinear FE models of SIB is rarely addressed by using data recorded from instrumented bridges. In this paper, the accuracy of a state‐of‐the‐art FE model is studied through nonlinear FE model updating (FEMU) of an existing instrumented SIB, the Marga‐Marga Bridge located in Viña del Mar, Chile. The seismic isolator models are updated in 2 phases: component‐wise and system‐wise FEMU. The isolator model parameters obtained from 23 isolator component tests show large scatter, and poor goodness of fit of the FE‐predicted bridge response to the 2010 Mw 8.8 Maule, Chile Earthquake is obtained when most of those parameter sets are used for the isolator elements of the bridge model. In contrast, good agreement is obtained between the FE‐predicted and measured bridge response when the isolator model parameters are calibrated using the bridge response data recorded during the mega‐earthquake. Nonlinear FEMU is conducted by solving single‐ and multiobjective optimization problems using high‐throughput cloud computing. The updated FE model is then used to reconstruct response quantities not recorded during the earthquake, gaining more insight into the effects of seismic isolation on the response of the bridge during the strong earthquake.
Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease
Authors: Yi Chenju , Ezan Pascal , Fernández Paola , Schmitt Julien , Sáez Juan C. , Giaume Christian , Koulakoff Annette 
Published: July 2017

AbstractThe contribution of reactive gliosis to the pathological phenotype of Alzheimer's disease (AD) opened the way for therapeutic strategies targeting glial cells instead of neurons. In such context, connexin hemichannels were proposed recently as potential targets since neuronal suffering is alleviated when connexin expression is genetically suppressed in astrocytes of a murine model of AD. Here, we show that boldine, an alkaloid from the boldo tree, inhibited hemichannel activity in astrocytes and microglia without affecting gap junctional communication in culture and acute hippocampal slices. Long‐term oral administration of boldine in AD mice prevented the increase in glial hemichannel activity, astrocytic Ca2+ signal, ATP and glutamate release and alleviated hippocampal neuronal suffering. These findings highlight the important pathological role of hemichannels in AD mice. The neuroprotective effect of boldine treatment might provide the basis for future pharmacological strategies that target glial hemichannels to reduce neuronal damage in neurodegenerative diseases.
Struggling to be liked: The prospective effect of trait self‐control on social desirability and the moderating role of agreeableness
Authors: Stavrova Olga , Kokkoris Michail D. 
Published: July 2017

AbstractDrawing from the literature on the interpersonal functions of self‐control, we examined longitudinal associations between trait self‐control and social desirability, using a survey of the general population in the Netherlands. Trait self‐control at baseline was positively associated with social desirability at a follow‐up, even when controlling for prior levels of social desirability. That is, high self‐control contributed to individuals' tendency to give socially desirable responses in self‐reports. This effect was moderated by individual differences in agreeableness. Highly agreeable individuals were more likely to “use” their self‐regulatory resources to respond in a socially desirable manner, compared to less agreeable individuals, suggesting that individuals might use self‐regulatory resources in a way consistent with the motivational bases of their personality.