bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПОКАЗНИКИ АЗОТОВОГО ОБМІНУ КУРЧАТ–БРОЙЛЕРІВ КРОСУ РОСС–308 ЗА СУМІСНОЇ ДІЇ ОХРАТОКСИНУ А ТА ДЕЗОКСИНІВАЛЕНОЛУ
Authors: Duhnytskyy V.B. , Boiko Y.V. , Boiko G.V. , Boiko N.І. 
Published: October 2016

Mycotoxicoses of farm animals cause the huge losses on a global scale, therefore the development of new methods for their treatment and prevention mycotoxins entry to organism of animals is still priority in veterinary toxicology.Today the understanding that the vast majority of animals mycotoxicoses cases is the mixed mycotoxicoses, that are resulting toxic effects of complex set of different mycotoxins, which complicates their diagnostics and prevention and treatment.Most of animals mycotoxicoses is a chronic disease at which disturbed metabolism, and the most vulnerable are lymphoid organs, liver, ductless glands and central nervous system. Therefore, treatment of animals should be complex – antidote, pathogenetic and symptomatic,and the search for new tools in the fight against mycotoxicosis in animals is a topical research direction in modern veterinary medicine.The article presents the experimental data about joint action of ochratoxin A and deoxynivalenol on nitrogenous metabolism parameters of broiler chickens. Conditions of nitrogenous metabolism in the organism of broiler chickens were studied by content of total protein, albumin, urea and creatinine. Established that the joint action of ochratoxin A and deoxynivalenol to the broiler chickens manifested dysproteinemia, that is the result of liver protein synthesis function disorder and absorption of protein cleavage products from the small intestine, owing to mucous membrane lesions through toxins. Increase of urea and creatinine in the blood plasma of broiler chickens by combined effect of ochratoxin A and deoxynivalenol is a result of disorder of renal excretory function due to exposure to toxins.
КЛІНІКО–ГЕМАТОЛОГІЧНІ ПОКАЗНИКИ КОРІВ ПІВНІЧНО–СХІДНОЇ БІОГЕОХІМІЧНОЇ ЗОНИ УКРАЇНИ ЗА РІЗНИХ ПЕРІОДІВ ЛАКТАЦІЇ
Authors: Grushanska N.G. , Kostenko V.M. 
Published: October 2016

Complicating effect of the adverse technogenic environmental factors that cause changes of biogeocoenose at the interaction with the natural deficiency of biogenic microelements, contributes to appearing and spread of pathology of mineral metabolism in farm animals, particularly in lactating cows. The question about the impact of the northern–eastern biogeochemical zone of Ukraine on the clinical and hematological parameters of cows at lactation’s period is studied insufficiently.The research was conducted in the three farms of Chernihiv region (northern–eastern biogeochemical zone).In the article the materials of our scientific research on determination of the clinical indicators among cows (heart rate, respiratory rate) are represented. The experimental diagnostic system is built on the principle: the sensor – amplifier – generator USW – modulator frequencies – antenna transmitter – receiver antenna – receiver – the computer. Blood was tested on the biochemical analyzer «Labline – 010» with standard set of reagents and the keeping conditions and ration of feeding cows were analized according to conventional methods.The benefits of remote diagnostic device for clinical signs of cows by researcher’s saving time on 37.5% are established. The clinical indicators and main indicators of metabolism among cows of the northern–eastern biogeochemical zones in the 8 – 15, 55 – 65, 150 – 170 day of lactation and 55 – 60 days befor calving are investigated.
ЕФЕКТИВНІСТЬ ДОБАВКИ «СИЛІМАСК» ЗА ЕКСПЕРИМЕНТАЛЬНОГО ТОКСИКОЗУ У ЩУРІВ
Authors: Zhuravlоv O. , Hunchak V. 
Published: October 2016

Chronic experimental poisoning of rats by carbon tetrachloride is accompanied by depression, reduced appetite, weak response to external stimuli. It has been shown a reduction of erythrocytes and hemoglobin in the blood of experimental animals. Eosinophilia and neutrophilia also was observed in these rats. A decrease of functional state of liver is by inhibition of protein synthesis and detoxification functions and significant increased of activity of transaminases and alkaline phosphatase. The use of supplements for medicinal purposes«Sylimask» helped restore the functional state of the experimental rats. On the 30 day experiment, the animals found in the blood increase the number of erythrocytes and hemoglobin. The presence in the composition of dietary supplements milled fruits of milk thistle, bee pollen and ascorbic acid provided an effective anti–inflammatory, antioxidant and hepatoprotective action on experimental hepatitis. Serum of rats by using biologically active supplements significantly increased serum total protein, including albumin, decreased activity of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase. The increase in blood catalase activity and inhibition of lipid peroxidation, as evidenced by a decrease in blood secondary and end products of oxidation by exposure «Sylimasku» is the result of activation of the drug enzymatic antioxidant system level. The use of for cure a preparation of comparison «Hepaton», which also contains in its composition the fruits milk thistle is a positive effect on chronic hepatitis B in the experimental rats. However, the impact of digital measurements was a less pronounced and the period of a full restoration of the functional state of animals longer.
ВПЛИВ ІМУНОМОДУЛЯТОРІВ НА ПОКАЗНИКИ КЛІТИННОГО ІМУНІТЕТУ ЛОШАТ ВЕРХОВИХ ПОРІД
Authors: Кrytsia I.P. 
Published: October 2016

To maintain a body at sufficient physiological level the effective functioning of the immune system, which determines the resistance and immune reactivity of animals, is necessary. In our studies in newborn foals indicators of cellular immunity were mature. During the studying of foals of all ages were established the reduction of hematological parameters in animals months of age.The use of immunomodulators prevents the immunodeficiency in animals. Immunomodulators introduction for animals normalizes T–immune system, in particular, increases the number of leucocytes in the blood, lymphocytes of certain populations, especially teofilin–resistant subpopulation of T–helper cells, increases the functional activity of lymphocytes.Under influence of ribotan revealed a trend to the increasing of T–lymphocytes by 0.2 – 1.2% (0.4 – 2.3%), respectively in Purebred Saddle and Ukrainian Saddle breeds. Results of the content of T–helper and T–suppressor cells in foals blood after ribotan administration showed that the use of immunomodulators not only increases the number of T–helper cells, but restores the ratio T–h / T–s, which returned to the optimal rate (1.9). Analyzing the functional status of T–lymphocytes during the application of immunomodulators was found the probable increase of the number of activated T–lymphocytes in Purebred Saddle foals more than 2–fold (P <0.01) and trend to increase of these cells in Ukrainian Saddle foals. In relation to thermostable T–lymphocytes, was note that the trend to the most optimal level of these cells installed in foals after administration of ribotan (values within 3 – 4%). The increasing in number of thermostable T–cells more than 4% indicates an increase power of suppressor T–cells population, indicating the inhibition of T–helper cells, and therefore the production of antibodies. Thus, the use of ribotan in dose of 1 ml / animal for three days leads to an increasing in 1.4 – 4.5% of the number of leukocytes in the blood of experimental group of foals compared with control animals. Under influence of ribotan in the blood of foals increases cell (number of T–lymphocytes in 0.4 – 2.3%) and functional activity (T–active lymphocytes in 2.3 times; P < 0.05) T–immune system. Under influence of cycloferon in the blood of foals increases the functional activity of T–immune system (the number of T–active lymphocytes in 16.7 – 25%; P < 0.05).
ВМІСТ МІКРОЕЛЕМЕНТІВ В СИРОВАТЦІ КРОВІ ТІЛЬНИХ КОРІВ РІЗНИХ БІОГЕОХІМІЧНИХ ПРОВІНЦІЙ
Authors: Saulko V. 
Published: October 2016

The article presents data on the content of certain trace elements in the blood serum of healthy and signs of micronutrient malnutrition calf cows from different biogeochemical provinces. The content of certain trace elements in the blood serum of healthy calf cows from different biogeochemical provinces varies significantly, however, is in the physiological range. In terms of biogeochemical province Ternopil region set reduction iodine and zinc in serum of cows at 2 – 23% to reflect the animal’s south–eastern provinces of Dnipropetrovsk, Sumy, Nikolaev and Donetsk regions. Serum animal’s biogeochemical province Sumy Oblast lowest content of copper, manganese and cobalt. Soils northeastern provinces biogeochemical obviously richer data micronutrients, resulting from the higher their content in blood serum of cows, however, the data is also not homogeneous. Serum cow’s biogeochemical province Dnipropetrovsk region below iodine, copper and cobalt at higher zinc and manganese compared to the figures of animal’s biogeochemical provinces Mykolayiv and Donetsk region. Even in clinically healthy cows of the experimental farms zinc in serum rather low (14.8 – 17.4 mmol/l). In animals with signs of disease on the lack of trace elements zinc in serum is lower at 17 – 29% (r ≤ 0.05 – 0.01) from healthy animals. Moreover, lowest zinc in the blood serum of animal’s biogeochemical province Ternopil region.In clinically healthy animals with biogeochemical province Dnipropetrovsk region manganese content in serum is the highest (4.10 ± 0.15 mmol/l), and even in animals with clinical signs of the disease was not significantly changed, whereas in animals from other provinces manganese content within 1.96 – 2.32 mmol/l, respectively 25 – 41% (r ≤ 0.01 – 0.001) below that of the clinically healthy animals in respective farms. The authentic reduction iodine, copper, manganese, cobalt and zinc in serum of animals with signs lack micronutrients different biogeochemical provinces. Thus, the iodine content in the blood serum of animals with signs lack micronutrients was at 16 – 24% Zinc at 17–29, on 22.6 – 41.1% copper, cobalt to manganese and 2.4 – 51% to 25 – 41% below that of the clinically healthy animals.
ВМІСТ ВАЖКИХ МЕТАЛІВ У КОРМАХ, ОРГАНІЗМІ ТВАРИН ТА ПРОДУКЦІЇ ТВАРИННИЦТВА В АГРОЕКОЛОГІЧНИХ УМОВАХ ЗАКАРПАТТЯ
Authors: Sachko R.G. , Lesyk Ja.V. , Luchka I.V. , Nevostruyeva I.V. 
Published: October 2016

We studied the content of Cadmium, Lead, Strontium and Nickel in the biological systems: environment – feed – animal – livestock products in agroecological conditions of Zacarpathian region. It is noted that the content of Cadmium and Strontium in soil samples taken from commercial land PAL «Lastochka», Uzhgorod district, Zacarpathian region did not exceed the maximum allowable concentrations, whereas the levels of Lead and Nickel were higher. The content of investigated elements in water used for watering cows in farm was 0.02–1.02 mg/l and did not exceed the maximum allowable concentrations which is up to veterinary and sanitary requirements. It is known from the literary sources that there is interdependency between the heavy metals level in soil and their accumulation in farming cultures. The obtained results of the study of heavy metals in feed (hay, straw, wheat, mixed fodder) harvested on the farm did not exceed the maximum allowable concentrations of studied elements in feed rations for animals. It is known that heavy metals in fodder transform in animal organism and have influence on the intensity of metabolic processes, physiological and biochemical condition and animal productivity. Concentrations of the elements in cows’ whole blood and hair were within physiological values. Absolute content of Cadmium, Lead, Strontium and Nickel in the milk of studied cows were under 0.014; 0.02; 0.15 and 0.2 mg/kg, respectively and did not exceed the maximum allowable concentrations.The analysis of coefficient of correlation between the heavy metals content in biological systems: environment – feed – animal – livestock products revealed the strong correlation between the heavy metals content in soil and water, in straw and mixed fodder, in blood, hair and milk, and the poorly expressed correlation between their content in catena: water – straw – blood – milk.
ГЕМАТОЛОГІЧНІ ТА МІКРОБІОЛОГІЧНІ ПОКАЗНИКИ, СТАН ПРИРОДНИХ МЕХАНІЗМІВ ЗАХИСТУ У КОРОПА ЗА ДІЇ ПРЕПАРАТУ «ФЛЮМЕК»
Authors: Solopova H. , Vishchur O. 
Published: October 2016

In the article presented results of own researches on the impact of antibacterial drug «Flyumek» on microbiological, hematological and immunological parameters of fish.The study was conducted in three groups of healthy age–2 carp, it was six animals each groups. The first group – research, through which the probe within 7 days of antibiotic «Flyumek» at 10 mg/kg of fish with 3% starch suspension, the second experimental group – 20 mg/kg of fish, the third group – control, received only 3% in starch suspension. Fish was kept in special trays under conditions of continuous closed system of water circulation. The material for the research served fish blood, which was taken after the experiment.For determine the sensitivity of pathogenic microorganisms of fish to the drug «Flyumek» was taken biological material from external integument, gills and internal organs (kidneys) carp with signs of the most common infectious diseases – Aeromonas infection. It was found a high antibacterial activity of the drug – diameter zone growth retardation culture around the disc was 25 mm.Investigated hematological parameters, particularly the number of red blood cells and hemoglobin concentration in the blood of carp experimental and control groups were within standard values for the age and species of fish. Not recorded probable changes in the number of red blood cells and hemoglobin concentration in the blood of experimental carp groups compared to control. This suggests no violation of the oxygen–transport function of red blood cells and hemolysis .Was studied parameters characterizing humoral nonspecific resistance – lysozyme and bactericidal activity of serum and content of circulating immune complexes. Stated that the fish that received study drug in an amount of 10 mg / kg, the content of circulating immune complexes was 51.7 ± 1.78 mmol/l and virtually no different from the control group, where their content – 50.3 ± 1.78 mmol/l, and the application of higher doses – 20 mg/kg, recorded an increase in their level to 60.3 ± 2.16 mmol/l, indicating a tendency to increase the antigenic load on the carp body . As a result dose of the drug «Flyumek» 10 mg/kg caused increase lysozyme and serum bactericidal activity of fish according to 10.0 (p < 0.05) and 11.5%. However, the use of larger doses – 20 mg/kg caused a downward trend bactericidal activity, but did not significantly affect the activity lysozyme serum.The results of the research indicate a high antibacterial activity of the drug «Flyumek» and no immunosuppressive action of investigational drug on humoral non–specific resistance of the organism carp. In this case, the drug dose of 10 mg/kg causes immune–stimulating effects on the natural defense mechanisms of fish.
ЕТІОЛОГІЧНА СТРУКТУРА ГОСТРИХ ШЛУНКОВО–КИШКОВИХ ЗАХВОРЮВАНЬ ТЕЛЯТ
Authors: Berezovskyi A. , Fotyna T. , Ulko L. , Nechyporenko A. , Tytov E. 
Published: October 2016

The results of tests of samples of biological material from the calves with acute gastrointestinal diseases presents in the article. It was found that the occurrence and development of acute gastrointestinal diseases the leading role played by opportunistic bacteria association: S. aureus, S. saprophiticus, S. agalactiae, S. faecalis, S. pyogenes, E. coli, E. cloacae, C. jejuni, P. vulgaris, P. mirabilis, P. aeruginosa and K. Pneumoniae. Of the 632 examinations we studied 2,786 samples of biological material. Analysis of the results on our diagnostic work shows that acute gastrointestinal disease in calves caused by microbial associations. At acute gastrointestinal disease isolated pathogen E. coli – 21.0%. Coccoid microorganisms group also had significant representation. Thus, a biomaterial of 15.5% was allocated S. faecalis, at 11.6% was allocated pathogen S. aureus. Although to a lesser extent, but large office in the species spectrum of microorganisms by acute gastrointestinal diseases of calves occupied S. agalactiae – 4.8%, S. saprophiticus – 4.6%, S. pyogenes – 3.7%. Among the important place occupied microorganisms culture P. vulgaris – 8.5% of the total allocation of the samples. The average discharge frequency was characteristic for Campylobacter jejuni – 6.5% of cases.In analyzing the sensitivity of microorganisms isolated from calves with acute gastro–intestinal diseases to different groups of antibiotic drugs found that E. coli has a low sensitivity to antibiotics almost all studied groups. The largest number of selected crops susceptible to cephalosporins – 74.8%. Most of the isolated cultures weaklysensitive or insensitive to antibiotics studied by us. These data are an indication of the spread of antibiotic–resistant strains of microorganisms among newborn calves in the farms of Sumy and Chernihiv regions, which explains the low efficiency of antibiotic therapy. Highly active towards crop S. aureus, S. saprophiticus, S. agalactiae, S. faecalis, S. pyogenes, E. coli, E. cloacae, C. jejuni, P. vulgaris, P. mirabilis, P. aeruginosa, and K. pneumoniae were drug «Ceftioklin» and combined antibacterial agents.
ДІАГНОСТИЧНИЙ ЕТАП ГІНЕКОЛОГІЧНОЇ ДИСПАНСЕРИЗАЦІЇ НЕПЛІДНИХ КОРІВ
Authors: Katsaraba O.A. , Dmytriv O.J. , Kostyshyn Ye.Ye. , Ivashkiv R.M. , Kudla I.M. , Sachuk R.M. 
Published: October 2016

The problem of obstetric and gynecological pathology is one of the first places among non–communicable animal diseases. To resolve this problem in Ukraine cows developed clinical examination, which includes a set of diagnostic, therapeutic and preventive measures aimed at creating healthy herds of animals.Equally important in preventing gynecological pathology given the planned health center, one of the stages of which are blood tests. Timely such studies can detect subclinical forms of metabolic disorders, prescribe the use of causal group, replaceableand pathogenetic therapy. Therefore, followin gour task during obstetric clinical examination cows to study blood parameters in fertile cows for 2 – 3 months after calving compared with cows that showed characteristic signs of sexual arousal stage of the cycle. It was established that the increase in blood cows sialic acids content above 253.0 USD, circulating immune complexes above 16.0 c.u., malondialdehyde levels above 8.14 mmol/L, diene conjugates above 2, 11 mmol/l and the average molecular weight of more than 1.05 indicates the course of inflammation in the development of sexual system and infertility.
ПРООКСИДАНТНО–АНТИОКСИДАНТНИЙ СТАТУС КОРІВ ЗА ГОНАДОПАТІЙ
Authors: Fedorenko S. 
Published: October 2016

Situational increase in the concentration of free oxide in the body for a reduction of antioxidant defense is accompanied by the development of pathological processes.One of the major cell damage by free radicals is the destruction of the fatty acids that make up cell membranes (lipid peroxidation). Peroxidation of lipids of biological membranes causes a disturbance of the barrier function and reduces the enzymatic activity; disintegrates receptor binding and vesicular transport. This leads to disruption of cellular activity, accelerated apoptosis degeneration, necrobiosis, atrophy and necrosis.The damaging effect of oxygen radicals in the cell antioxidant defense system opposed., protection function is performed by enzymes – superoxide dismutase, catalase, glutathione reductase, and low molecular weight non–enzymatic antioxidants (carotenoids, tocopherol), water soluble vitamins (ascorbic acid).Thus, the oxidation of lipid structures underlying the development of many diseases, including pathologies animal reproductive organs.Among the disorders of the reproductive function in cows is quite common gonadopathy such as gonadodystrophy, hypogonadism and hypoluteolisis on background endometritis (diorganspathology).The emergence and development of ovarian pathologies cows hypothetically can be supplemented by the existence of violations, failures in the prooxidant–antioxidant system, as the basis of these pathologies is a violation tropism, of complex mechanisms for metabolism and preserve cell structure and ovarian tissue.To determine the concentration of free oxide derivatives and antioxidant protection status in cows for ovariodystrophy, hypogonadism and diorgan pathology (endometritis↔hypoluteolisis) presents the materials the article.It is found that for cows ovarian pathologies compared to animals with the normal physiological state gonads malondialdehyde erythrocytes in blood was significantly increased by 10.4 –23.2 mm/l (25.3 – 56.8%), catalase activity was reduced to 13–14,4 m / H2O2 / l–min (56.9– 91.1%), reduced glutathione was reduced to 0.68–0.8 (16.1–19.1%).Installed status data of the antioxidant system in cows with gonadopathy show quite important determinant role in the genesis of ovarian pathologies.
ПОРІВНЯЛЬНА ОЦІНКА ДІЇ НОВОГО ПРЕПАРАТУ З ВІДОМИМ АНАЛОГОМ У ЕКСПЕРИМЕНТІ НА ЛАБОРАТОРНІЙ КУЛЬТУРІ МУХ РОДИНИ CALLIPHORIDAE
Authors: Shevchenko А. 
Published: October 2016

The article presents data on comparative evaluation of action of the new preparation Mucho–Mor with the well–known analogue in the experiment on laboratory culture of flies of the Calliphoridae family. Considering rapid emergence of resistance to insecticides in arthropods, it is suggested to introduce a new to the market alphamethrin compound as an active agent, and muscalur (cis–9–Tricosene) as the main attractant. An insecticide Fly Byte was selected as a test–drug for analysis of residual effects on different test sited, which is known as a leading product on the Ukrainian veterinary market for its quality and efficiency.It was established that the experimental sample of the drug Mucho–Mor showed a lasting residual action on laboratory culture of the flies Lucilia sericata. Thus, on the 6th day its lethal effect with the exposure for one hour on the glass and wooden surfaces was 16.7 and 17.8%, respectively, and was by 1.87 and 1.6 times higher compared to the experiment with Fly Bite. After three hours was observed 100% morbidity of all insects, which contacted with Mucho–Mor.Throughout the experiment, the new insecticide showed a pronounced knockdown effect, which affected 74.4 – 84.4% flies in the exposure of one hour. During the next two hours all the insects died. However, the lethal effect on the glass test surfaces was better than on the wooden surface up to the 50th day of exposure.
HYSTEROSCOPIC INVESTIGATION OF DAIRY COWS UTERUS WITH SUBCLINICAL ENDOMETRITIS
Authors: Basarab T.P. , Stefanyk V.Y. 
Published: October 2016

During the postpartum period among the dairy cattle there are cases of bacteriological infection of the uterus tissues. This process occurs in over 90% of the herd. If the animal wasn’t provided with early effective treatment, acute inflammation becomes a chronic disease. After analyzing published data, it was concluded that hysteroscopic studies are not described enough. For this study 5 (n = 5) cows of Ukrainian black and white breed, aged 4 to 6 years were selected, which had not shown estrus for over 25 days. Diagnosis was reached by hysteroscopy of uterus. Analysis of the data has proved that area size of bright red color of uterus with subclinical endometritis was – 57.6 ± 5.2%, whereas after the treatment with «Metrodek» it decreased by more than 7 times – 7.3 ± 1.6% (p < 0.001); area of exudate in the uterus with subclinical endmometritis was – 59.3 ± 6.5%, whereas after the treatment with «Metrodek» decreased about 11 times – 5.4 ± 1.1 % (p < 0,001).