bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dispersive liquid–liquid microextraction of phenolic compounds from vegetable oils using a magnetic ionic liquid
Authors: Zhu Shuqiang , Wang Lijun , Su Along , Zhang Haixia 
Published: June 2017

A novel method was developed for the determination of two endocrine‐disrupting chemicals, bisphenol A and 4‐nonylphenol, in vegetable oil by dispersive liquid–liquid microextraction followed by ultra high performance liquid chromatography with tandem mass spectrometry. Using a magnetic liquid as the microextraction solvent, several key parameters were optimized, including the type and volume of the magnetic liquid, extraction time, amount of dispersant, and the type of reverse extractant. The detection limits for bisphenol A and 4‐nonylphenol were 0.1 and 0.06 μg/kg, respectively. The recoveries were 70.4–112.3%, and the relative standard deviations were less than 4.2%. The method is simple for the extraction of bisphenol A and 4‐nonylphenol from vegetable oil and suitable for routine analysis.
Evaluating speech perception of the MAXUM middle ear implant versus speech perception under inserts
Authors: Dyer R. Kent , Spearman Michael , Spearman Brian , McCraney Anna 
Published: June 2017

Objectives/HypothesisTo evaluate the speech perception of the Ototronix MAXUM middle ear implant relative to the cochlear potential for speech perception of patients.Study DesignClinical study chart review.MethodsWe performed an evaluation of data from a prospective clinical study of 10 MAXUM patients. Primary outcome measures included comparison of word recognition (WR) scores with MAXUM (WRMAXUM) versus word recognition under inserts (WRinserts), and the functional gain improvement for pure‐tone average (PTA) (0.5, 1, and 2 kHz) and high‐frequency pure‐tone average (2, 3, and 4 kHz).ResultsTen ears in 10 adult patients (six female; average age 68.7 years) were included. The average speech perception gap (difference between WRinserts and WRMAXUM) with MAXUM was −9.2% (range, −26% to 4%). A negative number indicates that WRMAXUM was higher than the WRinserts. The average PTA with MAXUM was 23.1 dB (range, 18.7–30 dB), a 38.0‐dB gain over the preoperative unaided condition (range, 20–53.3 dB). The average high‐frequency pure‐tone average with MAXUM was 34.4 dB (range, 26–43.3 dB), a 42.8‐dB gain over the preoperative unaided condition (range, 32.3–58.7 dB).ConclusionsThese data demonstrate that a significant, very strong correlation was observed between WRinserts and WRMAXUM scores (r = 0.86, P = .001), and a patient's WRinserts score may be used to reasonably predict the word recognition outcomes with MAXUM.Level of Evidence4. Laryngoscope, 128:456–460, 2018
Systemic therapy for head and neck squamous cell carcinoma: Historical perspectives and recent breakthroughs
Authors: Blasco Michael A. , Svider Peter F. , Raza S. Naweed , Jacobs John R. , Folbe Adam J. , Saraf Pankhoori , Eloy Jean Anderson , Baredes Soly , Fribley Andrew M. 
Published: June 2017

ObjectivesDespite dramatic developments in drugs established for other malignancies, historically there have been few novel systemic agents available for the management of head and neck squamous cell carcinoma (HNSCC). However, the last decade has observed increased interest in targeted therapies for HNSCC. In 2006, cetuximab became the first major drug for HNSCC to gain Food and Drug Administration (FDA) approval in 3 decades. Recently, both pembrolizumab and nivolumab gained FDA approval for treatment of recurrent or metastatic HNSCC, and trials for other indications in HNSCC are actively underway. As older agents including cisplatin and 5‐fluorouracil continue to play a significant role in the management of advanced HNSCC, an understanding of their legacy is paramount. This historical review is not meant to exhaustively catalog every finding relating to HNSCC systemic therapy, but rather is meant to highlight important advances.Data SourcesCase series and clinical trials available in the literature.Review MethodsHistorically significant series and trials evaluating HNSCC systemic therapy were evaluated.ResultsStandard regimens employed today are largely comprised of drugs discovered over 4 decades ago, although a number of recent phase III clinical trials have shown great promise, leading to the adoption of several new chemotherapeutic agents and treatment strategies.ConclusionsThese findings reinforce the importance of supporting further HNSCC drug discovery as modern treatment strategies using systemic therapy have resulted in measurable improvements in oncologic outcomes. Laryngoscope, 127:2565–2569, 2017
Geographic region: Does it matter in cutaneous melanoma of the head and neck?
Authors: Kılıç Suat , Unsal Aykut A. , Chung Sei Y. , Samarrai Ruwaa , Kılıç Sarah S. , Baredes Soly , Eloy Jean Anderson 
Published: June 2017

Objectives/HypothesisThe head and neck are two of the most common locations for cutaneous melanoma. We present the first population‐based analysis of geographic differences in anatomic subsite, clinicopathologic and demographical traits, histopathologic subtype, treatment modality, and disease‐specific survival (DSS) of cutaneous head and neck melanoma (CHNM).Study DesignRetrospective database analysis.MethodsThe Surveillance, Epidemiology, and End Results database was queried for cases of CHNM reported between 2000 and 2013. Patients were grouped into East, Midwest, South, and West regions of the United States. Overall incidence, demographic traits, primary tumor site, clinicopathologic traits, histopathologic subtype, treatment modality, and DSS were compared among regions.ResultsThere were 49,365 patients with CHNM identified. The West (4.60) and the South (4.42) had significantly higher incidence (per 100,000) than the East (3.84) and Midwest (3.65) (P < .05). DSS was significantly different among regions (P < .0066). The East (5 years: 89.4%, 10 years: 84.1%) had the highest DSS rate, and the South (5 years: 87.0%, 10 years: 81.8%) had the lowest DSS rate. The Midwest (5 years: 88.4%, 10 years: 84.3%) and West (5 years: 88.3%, 10 years: 83.5%) had intermediate DSS. On multivariate analysis, the South had an elevated hazard ratio (1.17, 95% confidence interval: 1.05‐1.30) when compared to the West.ConclusionsGeographic region may play a significant role in CHNM. Incidence is higher in the South and the West. Incidence, histologic subtype, treatment modality, and DSS vary among regions. DSS is lower in the South than the West, even after accounting for other major prognostic factors.Level of Evidence4. Laryngoscope, 127:2763–2769, 2017
The robotic ENT microsurgery system: A novel robotic platform for microvascular surgery
Authors: Feng Allen L. , Razavi Christopher R. , Lakshminarayanan Pranav , Ashai Zaid , Olds Kevin , Balicki Marcin , Gooi Zhen , Day Andrew T. , Taylor Russell H. , Richmon Jeremy D. 
Published: June 2017

ObjectiveAssess the feasibility of a novel robotic platform for use in microvascular surgery.Study DesignProspective feasibility study.SettingRobotics laboratory.MethodsThe Robotic ENT (Ear, Nose, and Throat) Microsurgery System (REMS) (Galen Robotics, Inc., Sunnyvale, CA) is a robotic arm that stabilizes a surgeon's instrument, allowing precise, tremor‐free movement. Six microvascular naïve medical students and one microvascular expert performed microvascular anastomosis of a chicken ischiatic artery, with and without the REMS. Trials were blindly graded by seven microvascular surgeons using a microvascular tremor scale (MTS) based on instrument tip movement as a function of vessel width. Time to completion (TTC) was measured, and an exit survey assessed participants' experience. The interrater reliability of the MTS was calculated.ResultsFor microvascular‐naïve participants, the mean MTS score for REMS‐assisted trials was 0.72 (95% confidence interval [CI] 0.64–1.07) and 2.40 (95% CI 2.12–2.69) for freehand (P < 0.001). The mean TTC was 1,265 seconds for REMS‐assisted trials and 1,320 seconds for freehand (P > 0.05). For the microvascular expert, the mean REMS‐assisted MTS score was 0.71 (95% CI 0.15–1.27) and 0.86 (95% CI 0.35–1.37) for freehand (P > 0.05). TTC was 353 seconds for the REMS‐assisted trial and 299 seconds for freehand. All participants thought the REMS was more accurate and improved instrument handling and stability. The intraclass correlation coefficient for MTS ratings was 0.914 (95% CI 0.823–0.968) for consistency and 0.901 (95% CI 0.795–0.963) for absolute value.ConclusionThe REMS is a feasible adjunct for microvascular surgery and a potential teaching tool capable of reducing tremor in novice users. Furthermore, the MTS is a feasible grading system for assessing microvascular tremor.Level of EvidenceNA. Laryngoscope, 127:2495–2500, 2017
Simultaneous versus sequential bilateral cochlear implants in adults: Cost analysis in a US setting
Authors: Trinidade Aaron , Page Joshua C. , Kennett Sarah W. , Cox Matthew D. , Dornhoffer John L. 
Published: June 2017

Objectives/HypothesisFrom a purely surgical efficiency point of view, simultaneous cochlear implantation (SimCI) is more cost‐effective than sequential cochlear implantation (SeqCI) when total direct costs are considered (implant and hospital costs). However, in a setting where only SeqCI is practiced and a proportion of initially unilaterally implanted patients do not progress to a second implant, this may not be the case, especially when audiological costs are factored in. We present a cost analysis of such a scenario as would occur in our institution.Study DesignRetrospective review and cost analysis.MethodsBetween 2005 and 2015, 370 patients fulfilled the audiological criteria for bilateral implantation. Of those, 267 (72.1%) underwent unilateral cochlear implantation only, 101 (27.3%) progressed to SeqCI, and two underwent SimCI. The total hospital, surgical, and implant costs, and initial implant stimulation series audiological costs between August 2015 and August 2016 (29 adult patients) were used in this analysis.ResultsThe total hospital, surgical, and implant costs for this period was $2,731,360.42. Based on previous local trends, if a projected eight (27.3%) of these patients decide to progress to SeqCI, this will cost an additional $750,811.04, resulting in an overall total of $3,482,171.46 for these 29 patients. Had all 29 undergone SimCI, the total projected cost would have been $3,332,991.75, representing a total potential saving of $149,179.67 (4.3%).ConclusionsIn institutions where only SeqCI is allowed in adults, overall patient management may cost marginally more than if SimCI were practiced. This will be of interest to CI programs and health insurance companies.Level of Evidence4. Laryngoscope, 127:2615–2618, 2017
Serial office‐based steroid injections for treatment of idiopathic subglottic stenosis
Authors: Hoffman Matthew R. , Coughlin Adam R. , Dailey Seth H. 
Published: June 2017

Objectives/HypothesisCurrent treatment options for idiopathic subglottic stenosis include endoscopic interventions, resection, and tracheotomy. Recently, serial office‐based steroid injections were proposed as an alternative that may stabilize or induce regression of airway stenosis without the need for repeated operations. Procedure completion rate, pain, complications, effect on stenosis, time since the last operation, and limitations have not been described.Study DesignRetrospective case series.MethodsRetrospective series of 19 patients undergoing serial office‐based steroid injection for idiopathic subglottic stenosis. Outcome measures included completion rate, procedure‐related pain scores, complications, percentage of airway stenosis, and time since the last operative intervention.ResultsProcedure completion rate was 98.8%. Average pain score during the procedure was 2.3 ± 1.7 on a 10‐point scale. There were no immediate complications. One patient underwent awake tracheotomy 8 days after her second injection and was later decannulated. Average stenosis decreased from 35% ± 15% to 25% ± 15% (n = 16; P = .086) over the first of three injections and 40% ± 15% to 25% ± 10% to 20% ± 10% (n = 8; P = .002) for those patients completing two sets of three injections. Fourteen of 17 patients undergoing at least three injections have not returned to the operating room since the first injection.ConclusionsOffice‐based steroid injection represents a promising new treatment pathway for a disease that requires long‐term management, offering a purely pharmacologic approach to a disorder that has traditionally been approached from a mechanical perspective. It is safe, well tolerated, and effective. Furthermore, it may help patients and physicians avoid repeated trips to the operating room and the associated risks.Level of Evidence4. Laryngoscope, 127:2475–2481, 2017
Postoperative anticoagulation after free flap reconstruction for head and neck cancer: A systematic review
Authors: Barton Blair M. , Riley Charles A. , Fitzpatrick John C. , Hasney Christian P. , Moore Brian A. , McCoul Edward D. 
Published: June 2017

ObjectivePostoperative use of anticoagulation after free tissue transfer in head and neck ablative procedures is common practice, but a clear protocol has not been well established. The outcome measures including total flap failure, thrombosis, and hematoma formation for different anticoagulation regimens in free tissue transfer in the head and neck were reviewed.Data SourcesPubMed, Ovid, and Cochrane databases were examined for patients who underwent free tissue transfer following head and neck ablative procedures.Review MethodsPreferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines were utilized to identify English‐language studies reporting anticoagulation regimens following free tissue transfer in head and neck ablative procedures. Outcomes included total flap failure, thrombosis, and hematoma formation. Two independent reviewers assessed the quality of the articles by using the Methodological Index for Non‐Randomized Studies.ResultsA total of 368 articles were identified. An additional 36 articles were identified through screening of reference lists. Twenty‐one of these studies met final inclusion criteria for qualitative analysis. Outcome data on total flap failure, thrombosis, and hematoma formation were extracted and analyzed for comparison against all anticoagulation regimens. Total flap failure, thrombosis, and hematoma formation rates were 4.4%, 4.5%, and 2.2%, respectively. Individual study rates ranged from 0.0% to 10.7%, 0.0% to 10.4%, and 0.6% to 7.2%, respectively.ConclusionsThere is not adequate evidence to develop a standardized anticoagulation protocol for head and neck free flap procedures. Comparable flap complications were reported between all the employed anticoagulation methods studied, though significant variability in study design among articles existed. Prospective, randomized studies are warranted to determine the optimal postoperative anticoagulation regimen following free tissue transfer of the head and neck. Laryngoscope, 128:412–421, 2018
On restricted simple modules of contact Lie superalgebras of odd type
Authors: Liu Wende , Wang Shujuan , Yuan Jixia 
Published: June 2017

AbstractFor contact Lie superalgebras of odd type over an algebraically closed field of characteristic , the composition factors of Kac modules and the character formulas for all the restricted simple modules are explicitly determined. And the dimensions of simple modules in the restricted supermodule category are precisely calculated, thereby dimensions of all the restricted simple modules are given.
Compressed perovskite aqueous mixtures near their phase transitions show very high permittivities: New prospects for high‐field MRI dielectric shimming
Authors: Neves Ana L. , Leroi Lisa , Raolison Zo , Cochinaire Nicolas , Letertre Thibaut , Abdeddaïm Redha , Enoch Stefan , Wenger Jerome , Berthelot Johann , Adenot‐Engelvin Anne‐Lise , Malléjac Nicolas , Mauconduit Franck , Vignaud Alexandre , Sabouroux Pierre 
Published: June 2017

PurposePerovskites are greatly used nowadays in many technological applications because of their high permittivity, more specifically in the form of aqueous solutions, for MRI dielectric shimming. In this study, full dielectric characterizations of highly concentrated CaTiO3/BaTiO3 water mixtures were carried out and new permittivity maxima was reached.MethodsPermittivity measurements were done on aqueous solutions from 0%v/v to dry powder. The permittivity dependence with pressure was investigated. Scanning electron microscopy images were performed on a few representative solutions. BaTiO3 pressed pads of different thicknesses, permittivities, and distances to the head were compared in a 7T MRI scanner.ResultsPerovskite aqueous mixtures undergo a pressure‐dependent phase transition in terms of permittivity, with increasing water content. A new relative permittivity maximum of 475 was achieved. Microscopic images revealed structural differences between phases. A
improvement in the temporal lobe was obtained with thin, high permittivity BaTiO3 head.ConclusionsThis new preparation method allows improved pad geometry and placement, as a result of the high relative permittivity values achieved. This method has great significance for medical applications of MRI dielectric shimming, being easy to replicate and implement on a large scale. Magn Reson Med 79:1753–1765, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
A cross‐sectional study of the catheter management of neurogenic bladder after traumatic spinal cord injury
Authors: Lane Giulia I. , Driscoll Amy , Tawfik Kyrollos , Chrouser Kristin 
Published: June 2017

AimsThis cross‐sectional study describes the catheter management of neurogenic bladder (NGB) in patients with traumatic spinal cord injury (tSCI) with emphasis on the motivations behind transitions between intermittent (IC) and indwelling catheters.MethodsPatients at the Minneapolis VA with history of tSCI who utilized either intermittent catheterization (IC), urethral (UC) or suprapubic (SP) catheters, participated in a voluntary, anonymous survey regarding their bladder management strategies.ResultsA total of 100 patients participated, 94% were male and 90% Caucasian with median age of 61 years. Patients with current UC or SP were older than those utilizing IC (P = 0.002). The median age at injury and years since SCI were 32 years and 20.5 years, respectively. The median time with current modality was 11 years. A total of 27% of all patients reported at least one transition between catheter type. A total of 14 of 54 patients using IC had prior use of UC or SP, while 12/25 patients using SP and 10/21 patients using UC had prior use of IC. The most common reasons to stop IC included inconvenience, physician recommendation, and dislike of IC. A total of 53% of patients currently using UC or SP reported never using IC. Patients currently using SP were more content with their current catheterization method than those using UC or IC (P = 0.046).ConclusionsAmong patients using catheters for NGB, intermittent catheterization was the most common modality utilized and the transition between intermittent and indwelling catheter was most often influenced by patient preferences and clinician recommendations.
Numerical solution to a linear equation with tensor product structure
Authors: Fan Hung‐Yuan , Zhang Liping , Chu Eric King‐wah , Wei Yimin 
Published: June 2017

SummaryWe consider the numerical solution of a c‐stable linear equation in the tensor product space
, arising from a discretized elliptic partial differential equation in
. Utilizing the stability, we produce an equivalent d‐stable generalized Stein‐like equation, which can be solved iteratively. For large‐scale problems defined by sparse and structured matrices, the methods can be modified for further efficiency, producing algorithms of
computational complexity, under appropriate assumptions (with ns being the flop count for solving a linear system associated with
). Illustrative numerical examples will be presented.
Potent Prearranged Positive Allosteric Modulators of the Glucagon‐like Peptide‐1 Receptor
Authors: Jones Ben J. , Scopelliti Rosario , Tomas Alejandra , Bloom Stephen R. , Hodson David J. , Broichhagen Johannes 
Published: June 2017

AbstractDrugs that allosterically modulate G protein‐coupled receptor (GPCR) activity display higher specificity and may improve disease treatment. However, the rational design of compounds that target the allosteric site is difficult, as conformations required for receptor activation are poorly understood. Guided by photopharmacology, a set of prearranged positive allosteric modulators (PAMs) with restricted degrees of freedom was designed and tested against the glucagon‐like peptide‐1 receptor (GLP‐1R), a GPCR involved in glucose homeostasis. Compounds incorporating a trans‐stilbene comprehensively outperformed those with a cis‐stilbene, as well as the benchmark BETP, as GLP‐1R PAMs. We also identified major effects of ligand conformation on GLP‐1R binding kinetics and signal bias. Thus, we describe a photopharmacology‐directed approach for rational drug design, and introduce a new class of stilbene‐containing PAM for the specific regulation of GPCR activity.
Decontamination and Remediation of the Sulfur Mustard Simulant CEES with “Off‐the‐Shelf” Reagents in Solution and Gel States: A Proof‐of‐Concept Study
Authors: Hiscock Jennifer R. , Bustone Gianluca P. , Clark Ewan R. 
Published: June 2017

AbstractThe decontamination and remediation of sulfur mustard chemical warfare agents remains an ongoing challenge. Herein, we report the use of “off‐the‐shelf” metal salts alongside commercially available peroxides to catalyze the degradation of the simulant 2‐chloroethyl ethyl sulfide (CEES) in solution and encapsulated within a supramolecular gel.
Synthesis of methylene butyrolactone polymers from itaconic acid
Authors: Trotta Jacob T. , Jin Mengyuan , Stawiasz Katherine J. , Michaudel Quentin , Chen Wei‐Liang , Fors Brett P. 
Published: June 2017

ABSTRACTHerein, we report the transformation of β‐monomethyl itaconate, an inexpensive and biorenewable alternative to petroleum feedstocks, to the high‐value monomer α‐methylene‐γ,γ‐dimethyl‐γ‐butyrolactone (Me2MBL) through a selective addition strategy. This strategy is also applied to the synthesis of α‐methylene‐γ‐butyrolactone (MBL, tulipalin A), a monomer that can be polymerized to give materials with desirable properties (high decomposition temperature, glass transition temperature, and refractive index). Subsequent polymerization of both Me2MBL and MBL through reversible addition‐fragmentation chain‐transfer polymerization generates well‐defined poly(Me2MBL) and poly(MBL) (PMBL). Physical characterization of poly(Me2MBL) shows good physical properties comparable with known PMBL materials. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2730–2737