bluuebunny/crossref_metadata_2025_split huggingface dataset:
Examining Design for Development Online: An HCD Analysis of OpenIDEO Using HCD/UCD Metrics
Authors: Gordon Pierce , Fuge Mark , Agogino Alice 
Published: June 2016

OpenIDEO.com is an online collaborative platform developed to crowd source design talent across the Internet to tackle difficult interdisciplinary problems. Many of their design Challenges have focused upon issues concerning impoverished communities. Challenges include human sanitation solutions, alternatives for serving maternal health issues with mobile technologies, affordable learning tools, and social business models to improve health, and other pressing global quandaries. The platform uses tens of thousands of designers to contribute inspirations and design concepts for product and service-based solutions. The design process uses Human-Centered Design (HCD) techniques to develop interventions for the public and private sectors, in the form of products and services which are catered specifically to users’ needs. These products and services have considerable economic, social, and cultural benefits for firms and customers alike. In fact, the IDEO community has developed a Human-Centered Design (HCD) toolkit that helps designers develop products and services tailored for communities at the base of the pyramid. Although HCD techniques are practiced by IDEO consistently, a collection of larger HCD literature argues for parallel, yet slightly different, metrics of design success, which rarely have a chance to be tested against real-world settings. Fortunately, the rich content of OpenIDEO affords a novel opportunity to study the presence and effectiveness of HCD metrics in practice. By synthesizing seminal texts describing metrics for design thinking, we develop a collection of metrics that use empathetic methods to identify user needs. We then apply qualitative coding methods to find parallel themes between OpenIDEO Challenges that address issues in impoverished communities. Moreover, we use this comparison to answer the following questions:
1) Which, if any, of the HCD characteristics are potential predictors for successful designs?
2) How well do the present themes and metrics of the OpenIDEO design community correlate with metrics of Human-Centered Design?
These qualitative methods complement previous quantitative network analyses of the OpenIDEO network, in the hopes of developing benchmarks for HCD methods that successfully cater to user needs.
The Prevalence of Inappropriate Image Duplication in Biomedical Research Publications
Authors: Bik Elisabeth M. , Casadevall Arturo , Fang Ferric C. 
Published: June 2016

ABSTRACT
Inaccurate data in scientific papers can result from honest error or intentional falsification. This study attempted to determine the percentage of published papers that contain inappropriate image duplication, a specific type of inaccurate data. The images from a total of 20,621 papers published in 40 scientific journals from 1995 to 2014 were visually screened. Overall, 3.8% of published papers contained problematic figures, with at least half exhibiting features suggestive of deliberate manipulation. The prevalence of papers with problematic images has risen markedly during the past decade. Additional papers written by authors of papers with problematic images had an increased likelihood of containing problematic images as well. As this analysis focused only on one type of data, it is likely that the actual prevalence of inaccurate data in the published literature is higher. The marked variation in the frequency of problematic images among journals suggests that journal practices, such as prepublication image screening, influence the quality of the scientific literature.
Understanding CKD among patients with T2DM: prevalence, temporal trends, and treatment patterns—NHANES 2007–2012
Authors: Wu Bingcao , Bell Kelly , Stanford Amy , Kern David M , Tunceli Ozgur , Vupputuri Suma , Kalsekar Iftekhar , Willey Vincent 
Published: June 2016

ObjectiveTo describe the estimated prevalence and temporal trends of chronic kidney disease (CKD) treatment patterns, and the association between CKD and potential factors for type 2 diabetes mellitus (T2DM) in different demographic subgroups.Research design and methodsThis was a cross-sectional analysis of adults with T2DM based on multiple US National Health and Nutrition Examination Survey (NHANES) datasets developed during 2007–2012. CKD severity was defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines using the CKD Epidemiology Collaboration (CKD-EPI) equation: mild to moderate=stages 1–3a; moderate to kidney failure=stages 3b–5. Multivariable logistic regression analyses were performed to assess the associations between CKD and potential factors.ResultsOf the adult individuals with T2DM (n=2006), age-adjusted CKD prevalence was 38.3% during 2007–2012; 77.5% were mild-to-moderate CKD. The overall age-adjusted prevalence of CKD was 40.2% in 2007–2008, 36.9% in 2009–2010, and 37.6% in 2011–2012. The prevalence of CKD in T2DM was 58.7% in patients aged ≥65 years, 25.7% in patients aged <65 years, 43.5% in African-Americans and Mexican-Americans, and 38.7% in non-Hispanic whites. The use of antidiabetes and antihypertensive medications generally followed treatment guideline recommendations. Older age, higher hemoglobin A1c (HbA1c), systolic blood pressure (SBP), and having hypertension were significantly associated with CKD presence but not increasing severity of CKD.ConclusionsCKD continued to be prevalent in the T2DM population; prevalence remained fairly consistent over time, suggesting that current efforts to prevent CKD could be improved overall, especially by monitoring certain populations more closely.
Let's Talk About Sex! - Improving sexual health for patients in stroke rehabilitation
Authors: Guo Meiqi , Bosnyak Stephanie , Bontempo Tiziana , Enns Amie , Fourie Candice , Ismail Farooq , Lo Alex 
Published: June 2016

AbstractSexual health contributes greatly to quality of life. Research shows that stroke survivors want to learn and talk about sexual health, but are not given information. In keeping with the Canadian Best Practice Recommendations for Stroke Care, this project aimed to provide all stroke rehabilitation inpatients with the opportunity to discuss sexual health concerns with healthcare providers at West Park Healthcare Centre, a rehabilitation and complex continuing care centre in Toronto. Gap analysis conducted via staff member interviews and retrospective chart reviews showed that close to no patients were given the opportunity to discuss sexual health concerns at baseline.Plan-Do-Study-Act (PDSA) methodology was used as the project framework. The changes implemented included a reminder system, standardization of care processes for sexual health, patient-centred time points for the delivery of sexual health discussions, and the development of a sexual health supported conversation tool for patients with aphasia. By the end of the ten month project period and after three PDSA cycles, the percentage of patients provided with the opportunity to discuss sexual health during inpatient rehabilitation increased to 80%. This quality improvement project successfully implemented the Canadian Best Practice Recommendations for Stroke Care with respect to sexual health.Lessons learned included the importance of early baseline data collection and advance planning for tools used in QI projects. Future projects may focus on improving the discussion of sexual health concerns during outpatient stroke rehabilitation.
Exercise-related sudden cardiac arrest in London: incidence, survival and bystander response
Authors: Edwards Melanie J , Fothergill Rachael T 
Published: June 2016

ObjectiveThe study aimed to (1) establish the incidence of exercise-related sudden cardiac arrest (SCA) in London, (2) investigate survival from exercise-related SCA and (3) examine factors related to survival.MethodThis retrospective observational study examined 2 years’ data from the London Ambulance Service (LAS) cardiac arrest registry for patients in whom resuscitation was attempted following an out-of-hospital cardiac arrest (OHCA), a cardiac cause was presumed and the arrest occurred during or within 1 h of exercise.ResultsThe incidence of exercise-related SCA in London was estimated to be 0.6 per 100 000 person-years which equated to 0.5% of all OHCA, and 1.5% of all OHCA with presumed cardiac aetiology and resuscitation attempted. The majority of cases were male and the incidence increased from age 40 years. Just under one-third of patients survived to hospital discharge. Survival in the Utstein comparator group (cases with presumed cardiac aetiology, resuscitation attempted, bystander witnessed and a presenting cardiac rhythm of ventricular fibrillation or tachycardia) was higher at 42%. Survival was significantly associated with initial cardiac rhythm (χ2=17.5, df=2, p<0.001) and bystander defibrillation (Fisher's exact test, p<0.05).ConclusionsIncidence of exercise-related SCA in the general population in London is rare. Survival following exercise-related SCA was considerably higher than survival for all OHCA with presumed cardiac aetiology and resuscitation attempted attended by the LAS during the same period. The major limitation of the study is the likely under identification of cases of exercise-related SCA.
Patient-Reported Outcome Measures (PROMS) in patients undergoing heart valve surgery: why should we measure them and which instruments should we use?
Authors: Holmes Charlotte , Briffa Norman 
Published: June 2016

ObjectiveAs the population ages, the incidence of heart valve disease (HVD) is increasing. The aim of treatment is to improve prognosis and quality of life. Standard surgical treatment is being superseded by new catheter-based treatments, many of which are as yet unproven. The need for appropriate instruments to measure quality of life in patients receiving treatment for HVD has therefore never been greater.MethodsIn this prospective observational study, a generic instrument, Euroqol, and a disease-specific one (Minnesota Living with Heart Failure Questionnaire—MLHFQ) were, for the first time, formally tested before and after surgery in 84 patients with HVD who completed their treatment. Patients were interviewed on the night before surgery and 6–12 weeks after being discharged. Instruments were tested for validity, reliability, responsiveness, sensitivity and interpretability.ResultsBoth Euroqol and MLHFQ registered significant improvements in patients' health. Tests for validity were significantly positive for both Euroqol and MLHFQ. Tests for reliability and responsiveness were very positive for MLHFQ, less so for EQ-5D. There was a moderate ceiling effect in the postoperative Index scores of Euroqol and a moderate floor effect in MLHFQ.ConclusionsBoth instruments together performed very well in assessing the health of patients undergoing surgical treatment of HVD. As the incidence of HVD increases and therapeutic options increase, measurement of PROMS using these two instruments should become a matter of routine.
Mortality pattern and cause of death in a long-term follow-up of patients with STEMI treated with primary PCI
Authors: Doost Hosseiny Ataollah , Moloi Soniah , Chandrasekhar Jaya , Farshid Ahmad 
Published: June 2016

ObjectiveWe aimed to assess the pattern of mortality and cause of death in a cohort of patients with ST-segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PCI).MethodsConsecutive patients with STEMI treated with primary PCI during 2006–2013 were evaluated with a mean follow-up of 3.5 years (1–8.4 years). We used hospital and general practice records and mortality data from The Australian National Death Index.ResultsAmong 1313 patients (22.5% female) with mean age of 62.3±13.1 years, 181 patients (13.7%) died during long-term follow-up. In the first 7 days, 45 patients (3.4%) died, 76% of these due to cardiogenic shock. Between 7 days and 1 year, another 50 patients died (3.9%), 58% from cardiovascular causes and 22% from cancer. Beyond 1 year, there were 86 deaths with an estimated mean mortality rate of 2.05% per year, 36% of deaths were cardiovascular and 52% non-cardiovascular, including 29% cancer-related deaths. On multivariate analysis, age ≥75 years, history of diabetes, prior PCI, cardiogenic shock, estimated glomerular filtration rate (eGFR) <60 and symptom-to-balloon time >360 min were independent predictors of long-term mortality. In 16 patients who died of sudden cardiac death postdischarge, only 4 (25%) had ejection fraction ≤35% and would have been eligible for an implantable cardioverter defibrillator.ConclusionsIn the era of routine primary PCI, we found a mortality rate of 7.3% at 1 year, and 2.05% per year thereafter. Cause of death was predominantly cardiovascular in the first year and mainly non-cardiovascular after 1 year. Age, diabetes, prior PCI, cardiogenic shock, eGFR <60 and delayed treatment were independent predictors of mortality.
Concurrent cranial and caudal sartorius muscle flaps for reconstruction of an abdominal wall defect after resection of a high‐grade rhabdomyosarcoma in a dog
Authors: Rubinos Carlos , Trinterud Tonje , Demetriou Jackie 
Published: June 2016

A five‐year‐old male neutered border collie presented with a soft tissue sarcoma in his right flank. CT revealed that the mass originated from the right rectus abdominis muscle. The mass was removed en bloc with 3 cm lateral margins and full‐thickness abdominal wall resection. A 15 cm diameter full‐thickness defect was created in the right caudal ventrolateral aspect of the abdomen, which was closed in one stage by transposition of the cranial and caudal bellies of the sartorius muscle. The recovery was favourable and the histopathology‐immunohistochemistry results provided a final diagnosis of high‐grade rhabdomyosarcoma and confirmed complete resection of the mass. The dog was fully ambulatory with no evidence of lameness, metastatic disease or recurrence of local disease 12 months postoperatively.
Effects of heterogeneous traffic with speed limit zone on the car accidents
Authors: Marzoug R. , Lakouari N. , Bentaleb K. , Ez-Zahraouy H. , Benyoussef A. 
Published: June 2016

Using the extended Nagel–Schreckenberg (NS) model, we numerically study the impact of the heterogeneity of traffic with speed limit zone (SLZ) on the probability of occurrence of car accidents [Formula: see text]. SLZ in the heterogeneous traffic has an important effect, typically in the mixture velocities case. In the deterministic case, SLZ leads to the appearance of car accidents even in the low densities, in this region [Formula: see text] increases with increasing of fraction of fast vehicles [Formula: see text]. In the nondeterministic case, SLZ decreases the effect of braking probability [Formula: see text] in the low densities. Furthermore, the impact of multi-SLZ on the probability [Formula: see text] is also studied. In contrast with the homogeneous case [X. Li, H. Kuang, Y. Fan and G. Zhang, Int. J. Mod. Phys. C 25 (2014) 1450036], it is found that in the low densities the probability [Formula: see text] without SLZ [Formula: see text] is low than [Formula: see text] with multi-SLZ [Formula: see text]. However, the existence of multi-SLZ in the road decreases the risk of collision in the congestion phase.
Phenotypic and Signaling Consequences of a Novel Aberrantly Spliced Transcript FGF Receptor-3 in Hepatocellular Carcinoma
Authors: Li Ke , Shen Baiyong , Cheng Xi , Ma Ding , Jing Xiaoqian , Liu Xinyu , Yang Weiping , Peng Chenghong , Qiu Weihua 
Published: June 2016

AbstractFibroblast growth factor receptor 3 (FGFR3) plays important roles in cell proliferation, differentiation, and angiogenesis. FGFR3 is abnormally upregulated in hepatocellular carcinoma (HCC), where it correlates positively with clinicopathologic index, HCC differentiation, and advanced nuclear grade. In this study, we describe an aberrantly spliced transcript of FGFR3, termed FGFR3Δ7-9, was identified as a high frequency even in HCC. FGFR3Δ7-9 lacks exons encoding the immunoglobulin-like III domain and promoted the proliferation, migration, and metastasis of HCC cells both in vitro and in vivo. Coimmunoprecipation and surface plasmon resonance assays demonstrated that the binding affinity of the aberrant FGFR3Δ7-9 receptor to FGFs was significantly higher than wild-type FGFR3IIIc. Furthermore, FGFR3Δ7-9 could be self-activated by homodimerization and autophosphorylation even in the absence of ligand. Finally, FGFR3Δ7-9 more potently induced phosphorylation of the ERK and AKT kinases, leading to abnormal downstream signaling through the ERK and PI3K/AKT/mTOR pathways. FGFR3Δ7-9 also upregulated the metastasis-associated molecules Snail, MMP-9, and downregulated E-cadherin, which associated directly with FGFR3Δ7-9. Thus, as a ligand-dependent or -independent receptor, FGFR3Δ7-9 exerted multiple potent oncogenic functions in HCC cells, including proliferation, migration, and lung metastatic capacity. Overall, FGFR3 mRNA missplicing in HCC contributes significantly to its malignant character, with implications for therapeutic targeting. Cancer Res; 76(14); 4205–15. ©2016 AACR.
Biomarker Associations with Efficacy of Abiraterone Acetate and Exemestane in Postmenopausal Patients with Estrogen Receptor–Positive Metastatic Breast Cancer
Authors: Li Weimin , O'Shaughnessy Joyce , Hayes Daniel , Campone Mario , Bondarenko Igor , Zbarskaya Irina , Brain Etienne , Stenina Marina , Ivanova Olga , Graas Marie-Pascale , Neven Patrick , Ricci Deborah , Griffin Thomas , Kheoh Thian , Yu Margaret , Gormley Michael , Martin Jason , Schaffer Michael , Zelinsky Kathy , De Porre Peter , Johnston Stephen R.D. 
Published: June 2016

Abstract
Purpose: Abiraterone may suppress androgens that stimulate breast cancer growth. We conducted a biomarker analysis of circulating tumor cells (CTCs), formalin-fixed paraffin-embedded tissues (FFPETs), and serum samples from postmenopausal estrogen receptor (ER)+ breast cancer patients to identify subgroups with differential abiraterone sensitivity.
Methods: Patients (randomized 1:1:1) were treated with 1,000 mg/d abiraterone acetate + 5 mg/d prednisone (AA), AA + 25 mg/d exemestane (AAE), or exemestane. The biomarker population included treated patients (n = 293). The CTC population included patients with ≥3 baseline CTCs (n = 104). Biomarker [e.g., androgen receptor (AR), ER, Ki-67, CYP17] expression was evaluated. Cox regression stratified by prior therapies in the metastatic setting (0/1 vs. 2) and setting of letrozole/anastrozole (adjuvant vs. metastatic) was used to assess biomarker associations with progression-free survival (PFS).
Results: Serum testosterone and estrogen levels were lowered and progesterone increased with AA. Baseline AR or ER expression was not associated with PFS in CTCs or FFPETs for AAE versus exemestane, but dual positivity of AR and ER expression was associated with improved PFS [HR, 0.41; 95% confidence interval (CI), 0.16–1.07; P = 0.070]. For AR expression in FFPETs obtained &lt;1 year prior to first dose (n = 67), a trend for improved PFS was noted for AAE versus exemestane (HR, 0.56; 95% CI, 0.24–1.33; P = 0.19).
Conclusions: An AA pharmacodynamic effect was shown by decreased serum androgen and estrogen levels and increased progesterone. AR and ER dual expression in CTCs and newly obtained FFPETs may predict AA sensitivity. Clin Cancer Res; 22(24); 6002–9. ©2016 AACR.
Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer
Authors: Hamilton Duane H. , Griner Lesley Mathews , Keller Jonathan M. , Hu Xin , Southall Noel , Marugan Juan , David Justin M. , Ferrer Marc , Palena Claudia 
Published: June 2016

Abstract
Purpose: The conversion of tumor cells from an epithelial to a mesenchymal-like phenotype, via a process designated as the epithelial–mesenchymal transition (EMT), is known to mediate tumor resistance to a variety of cell death inducers, including cytotoxic effector immune cells. The goal of this study was to identify and potentially repurpose FDA-approved compounds capable of reducing mesenchymal features of human lung carcinoma cells, which could be used in combination with immunotherapies or chemotherapeutic strategies to improve clinical responses.
Experimental Design: In the current report, we have utilized a quantitative high-throughput screening (qHTS) of a pharmaceutical collection of more than 2,000 compounds to identify clinically approved drugs capable of augmenting the sensitivity of mesenchymal-like, lung cancer cells to immune- and chemotherapy-mediated lysis, both in vitro and in vivo.
Results: The estrogen receptor antagonist fulvestrant was shown to reduce mesenchymal features of lung carcinoma cells, resulting in tumor sensitization to the cytotoxic effect of antigen-specific T cells, natural killer (NK) effector cells, and chemotherapy both in vivo and in vitro.
Conclusions: To our knowledge, this is the first report defining a potential role for estrogenic signaling in promoting tumor resistance to immune-mediated cytotoxicity and chemotherapy in lung cancer. Our data demonstrate a robust association between the acquisition of mesenchymal attributes, therapeutic resistance of lung carcinoma cells, and the expression of estrogen receptor 1 (ESR1), supporting further investigations on the role of estrogen signaling in lung cancer progression via the induction of EMT. Clin Cancer Res; 22(24); 6204–16. ©2016 AACR.
Unique Abnormalities in Right Ventricular Longitudinal Strain in Systemic Sclerosis Patients
Authors: Mukherjee Monica , Chung Shang-En , Ton Von Khue , Tedford Ryan J. , Hummers Laura K. , Wigley Fredrick M. , Abraham Theodore P. , Shah Ami A. 
Published: June 2016

Background—
Cardiac involvement in systemic sclerosis (scleroderma [SSc]) adversely affects long-term prognosis, often remaining undetectable despite close clinical examination and 2-dimensional echocardiographic monitoring. Speckle-derived strain of the right ventricle (RV) was utilized to detect occult abnormalities in regional and global contractility in SSc patients.

Methods and Results—

A total of 138 SSc patients with technically adequate echocardiograms was studied and compared with 40 age- and sex-matched healthy non-SSc controls. Standard assessment of RV chamber function included tricuspid annular plane systolic excursion and fractional area change. RV longitudinal systolic speckle-derived strain was assessed in the basal, mid, and apical free wall. Tricuspid annular plane systolic excursion was not different between groups (
P
=0.307). Although fractional area change was lower in SSc patients than in controls (mean, 48.9 versus 55;
P
=0.002), the mean fractional area change was still within the normal range (>35). In contrast, RV longitudinal systolic speckle-derived strain measures were significantly different between groups, both globally (−20.4% versus −17.7%;
P
=0.005) and regionally: they were decreased in the apex (−8.5% versus −17.1%;
P
<0.0001) and mid segments (−12.4% versus -20.9%;
P
<0.0001), and increased in the base (−32.2% versus −23.3%;
P
=0.0001) for the SSc group. The regional difference in the base compared with the apex was significantly greater for SSc than for controls (
P
<0.0001 for interaction). The differences observed in regional strain between SSc and control were unchanged after adjusting for RV systolic pressure.

Conclusions—
Speckle-derived strain reveals a heterogenous pattern of regional heart strain in SSc that is not detected by conventional measures of function, suggestive of occult RV myocardial disease.