bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pathologic Response of Phase III Study: Perioperative Camrelizumab Plus Rivoceranib and Chemotherapy Versus Chemotherapy for Locally Advanced Gastric Cancer (DRAGON IV/CAP 05)
Authors: Li Chen , Tian Yantao , Zheng Yanan , Yuan Fei , Shi Zheng , Yang Lin , Chen Hao , Jiang Lixin , Wang Xixun , Zhao Ping , Zhang Benyan , Wang Zhenqiang , Zhao Qun , Dong Jianhong , Lian Changhong , Xu Sanrong , Zhang Aimin , Zheng Zhichao , Wang Kang , Dang Chengxue , Wu Dan , Chen Jian , Xue Yingwei , Liang Bo , Cheng Xiangdong , Wang Qian , Chen Luchuan , Xia Tao , Liu Heli , Xu Dazhi , Zhuang Jing , Wu Tao , Zhao Xi , Wu Wei , Wang Hongzhi , Peng Junsheng , Hou Zhiguo , Zheng Rongrong , Chen Yuting , Yin Kai , Zhu Zhenggang 
Published: October 2024

PURPOSE
This multicenter, randomized phase III trial evaluated the efficacy and safety of perioperative camrelizumab (an anti–PD-1 antibody) plus low-dose rivoceranib (a VEGFR-2 inhibitor) and S-1 and oxaliplatin (SOX) (SOXRC), high-dose rivoceranib plus SOX (SOXR), and SOX alone (SOX) for locally advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma.

METHODS
Patients with T3-4aN + M0 G/GEJ adenocarcinoma were randomly assigned (1:1:1) to receive perioperative treatment with SOXRC, SOXR, or SOX. The primary end points were pathologic complete response (pCR) and event-free survival. The Independent Data Monitoring Committee recommended stopping enrollment in the SOXR group on the basis of the safety data of the first 103 randomly assigned patients in the three groups. The patients were then randomly assigned 1:1 to the SOXRC or SOX groups. This report presents the pCR results obtained per protocol for the first 360 randomly assigned patients who had the opportunity for surgery in the SOXRC and SOX groups.

RESULTS

In the SOXRC and SOX groups, of the 180 patients in each group, 99% and 98% of patients received neoadjuvant therapy, 91% and 94% completed planned neoadjuvant therapy, and 86% and 87% underwent surgery, respectively. The pCR was significantly higher in the SOXRC group at 18.3% (95% CI, 13.0 to 24.8) compared with 5.0% (95% CI, 2.3 to 9.3) in the SOX group (difference of 13.7%; 95% CI, 7.2 to 20.1; odds ratio of 4.5 [95% CI, 2.1 to 9.9]). The one-sided
P
value was <.0001, crossing the prespecified statistical significance threshold of
P
= .005. Surgical complications and grade ≥3 neoadjuvant treatment-related adverse events were 27% versus 33% and 34% versus 17% for SOXRC and SOX, respectively.

CONCLUSION
The SOXRC regimen significantly improved pCR compared with SOX alone in patients with G/GEJ adenocarcinoma with a tolerable safety profile.
Quantum data compression under localized features
Authors: Han Qi , Gou Lijie , Wang Shuai , Zhang Rong 
Published: October 2024

Abstract
In this paper, we first introduce the local quantum information processing task by compressing the density operator based on local quantum Bernoulli noises. Then, the local quantum compression theorem is given, that is, the local quantum entropy is the minimum achievable rate of local compression. Finally, we prove the theorem with the proof of the direct coding theorem and the inverse theorem. The direct coding theorem shows that a scheme with such a local compression rate exists, and that this local compression rate converges to the local quantum entropy. The inverse theorem shows that the compression scheme with the rate below the local entropy is unachievable. With the continuous development of quantum technology, local quantum data compression technology will have broad application prospects and development space.
ACTH Stimulation and Oral Salt Loading Tests Detect Biochemical Outcome Early After Primary Aldosteronism Surgery
Authors: Ishida Yuto , Nakai Kazuki , Watanabe Kazuki , Hirose Rei , Saito Jun , Nishikawa Tetsuo , Tsurutani Yuya 
Published: October 2024

Abstract

Background
In primary aldosteronism (PA), the biochemical outcomes of the Primary Aldosteronism Surgical Outcome study are used to assess aldosterone hypersecretion 6 to 12 months after surgery. However, few studies have investigated whether the outcomes can be predicted in the early postoperative period. In this retrospective study, we evaluated whether the adrenocorticotropin stimulation test (AST) and oral salt loading test (OST) performed immediately after surgery could predict biochemical outcomes 1 year after surgery.

Methods
We assessed 268 patients with PA who underwent adrenalectomy at our hospital between 2008 and 2020, underwent AST and OST within 15 days of surgery, and were assessed for biochemical outcomes 1 year after surgery. Patients were divided into 2 groups: biochemical complete success (B-com; n = 219) and incomplete success (B-inc; n = 49). Patients were divided into clinical complete and partial success and absent success groups. The relationships between various AST and OST values and outcomes were analyzed.

Results
The B-inc group had significantly higher plasma aldosterone concentration (PAC) and PAC/serum cortisol ratio (PAC/Cort) at baseline and after ACTH loading in AST and 24-hour urine aldosterone in OST than the B-com group. PAC/Cort at 30 minutes after ACTH loading [area under the curve (AUC) = 0.76] and 24-hour urine aldosterone (AUC = 0.77) were relatively superior predictors of the outcome. Parameters after ACTH loading were better predictors of biochemical and clinical outcomes than baseline.

Conclusion
AST and OST immediately after surgery can predict biochemical and clinical outcomes 1 year after surgery in patients with PA.
Low-Level Mosaic GCK Mutations in Children With Diazoxide-Unresponsive Congenital Hyperinsulinism
Authors: Boodhansingh Kara E , Lord Katherine , Adzick N Scott , Bhatti Tricia , Ganguly Arupa , Stanley Charles A , De Leon Diva D 
Published: October 2024

Abstract

Context
Some children with diazoxide-unresponsive congenital hyperinsulinism (HI) lack any detectable disease-causing mutation in peripheral-blood DNA.

Objective
This work aimed to examine whether somatic postzygotic mutations of known HI genes are responsible for disease in children with diazoxide-unresponsive HI requiring surgery with histology not classified as focal or localized islet nuclear enlargement (LINE), and without detectable mutations by standard genetic testing of peripheral blood DNA.

Methods
Next-generation sequencing (NGS) was performed on specimens of pancreas from 10 children with diazoxide-unresponsive HI.

Results
Four unique GCK mutations were identified at low levels of mosaicism ranging from 4.4% to 10.1% in pancreatic DNA from 5 of these 10 children. The GCK mutations were not detectable in peripheral-blood DNA by NGS in 3 cases from which peripheral-blood DNA was available for testing. All 4 GCK mutations have been previously published as activating HI mutations. The histology was consistent with diffuse HI in 4 of the 5 cases with mosaic GCK mutations. In one of these, hypomethylation of IC2 on chromosome 11p was identified in pancreatic and peripheral-blood DNA. Histology of the fifth case revealed minor islet abnormalities suggestive of Beckwith-Wiedemann spectrum although molecular analysis for 11pUPD was negative in pancreas.

Conclusion
These results indicate that postzygotic somatic GCK mutations are responsible for some cases of nonfocal diazoxide-unresponsive HI.
Cicada minimum age tree: Cryptic speciation and exponentially increasing base substitution rates in recent geologic time
Authors: Osozawa Soichi , Wakabayashi John 
Published: October 2024

We developed a new time-calibrated tree incorporating primarily endemic along with some cryptic Ryukyu islands cicada data, following the recent publication of global cicada data by Marshall et al. (2018), Łukasik et al. (2018), Simon et al. (2019), Price et al. (2019), and Hill et al. (2021). A total of 352 specimens were analyzed using BEAST v1. X software with a relaxed clock model. Fossil calibrations as old as Triassic were adopted largely following Johnson et al. (2018) and Moulds (2018), and a Quaternary geological event calibration was adopted following Osozawa et al. (2012, 2021b) and input into BEAST v1. X. Our timetree suggests that Tettigarctidae had a cicada basal lineage as old as 200.63 Ma, with Derotettiginae the next oldest lineage at 99.2 Ma. Tibicininae is a sister of the remaining subfamilies of Tettigomyiinae, Cicadettinae, and Cicadidae, and their species level differentiation and radiation began at 40.57 Ma. The Cicadinae clade consists of specific tribes with paraphyletic relationship, and the vicariance and adaptive radiation generated many cryptic species in each tribe. We estimated base substitution rate as a function of age, and the result strongly indicates an exponential increase of base substitution rate in recent geologic time. The consequent increase in cicada biodiversity, including generation of cryptic species in the Ryukyu Islands and surroundings, may have been driven by the generation and spreading of C4 grasses and coeval Quaternary climate change.
Tunable frequency conversion in doped photonic crystal fiber pumped near degeneracy
Authors: Murphy Leah R. , Olszewski Mateusz J. , Androvitsaneas Petros , Alvarez Perez Miguel , Smith Will A. M. , Bennett Anthony J. , Mosley Peter J. , Davis Alex O. C. 
Published: October 2024

Future quantum networks will rely on the ability to coherently transfer optically encoded quantum information between different wavelength bands. Bragg-scattering four-wave mixing in optical fiber is a promising route to achieving this, but requires fibers with precise dispersion control and broadband transmission at signal, target, and pump wavelengths. Here, we introduce a photonic crystal fiber with a germanium-doped core featuring group velocity matching at 1550 nm, the telecoms C-band, and 920 nm, within the emission range of efficient single photon sources based on InAs quantum dots. With low chromatic walk-off and good optical guidance even at long wavelengths, large lengths of this fiber are used to achieve nanometer-scale frequency shifts between wavelengths around 920 nm with up to 79.4% internal conversion efficiency, allowing dissimilar InAs dots to be interfaced. We also show how cascading this frequency conversion can be used to generate a frequency comb away from telecoms wavelengths. Finally, we use the fiber to demonstrate tunable frequency conversion of weak classical signals around 918 nm to the telecoms C-band.
Household expenditure on control of urban mosquitoes Aedes albopictus and Culex pipiens in Emilia-Romagna, Northern Italy
Authors: Canali Massimo , Vici Laura , Rivas Morales Stefano , Donati Luciano , Matrangolo Carmela , Venturelli Claudio , Angelini Paola , Dottori Michele , Bellini Romeo , Carrieri Marco 
Published: October 2024

Background
In 2007, the first outbreak of Chikungunya in Italy generated great alarm, highlighting the health risks caused by exotic species recently introduced in Europe and the need to strengthen control actions against the vectors. Besides health risks, mosquitoes cause nuisance, and citizens are required to adopt control measures. While the economic aspects of mosquito control by public agencies have been investigated, the scientific literature on the costs of mosquito protection incurred by families is scarce.
This study assessed the households’ expenditure on protective measures against mosquitoes in Emilia-Romagna, a region in Northern Italy.

Methodology/Principal findings
A phone questionnaire survey was conducted to collect data on the annual expenditure incurred by households for self-protection against mosquitos in relation to the perceived level of nuisance and the household and dwelling characteristics. Univariate and multivariate analyses were conducted to identify the main determinants influencing such expenditure, which resulted affected by dwelling characteristics, presence of children under 6 years of age, and health concerns of family members. The average annual household expenditure was estimated at 84.63 euros, about 30 times higher than the expenditure per household supported by regional and local administrations for interventions against mosquitoes in public areas, as calculated in a previous study.

Conclusion/Significance
Household expenditure is mainly aimed at providing a direct defense against mosquito bites (mosquito nets, adulticides, skin-on repellents, etc.) while spending for more effective measures addressed to reduce mosquito density results marginal: e.g., only 3.5% of the total expenditure was dedicated to larval control.
Control activities that lower the mosquito density in both private and public areas could reduce the use of household insecticides in urban environments and the related costs, and the risk of spread of imported arboviruses as well.
Predicting harmful alcohol use prevalence in Sub-Saharan Africa between 2015 and 2019: Evidence from population-based HIV impact assessment
Authors: Goma Mtumbi , Ng’ambi Wingston Felix , Zyambo Cosmas 
Published: October 2024

Introduction
Harmful alcohol use is associated with significant risks to public health outcomes worldwide. Although data on harmful alcohol use have been collected by population-based HIV Impact Assessment (PHIA), there is a dearth of analysis on the effect of HIV/ART status on harmful alcohol use in the Sub-Saharan Africa (SSA) countries with PHIA surveys.

Methods
A secondary analysis of the PHIA surveys: Namibia (n = 27,382), Tanzania (n = 1807), Zambia (n = 2268), Zimbabwe (n = 3418), Malawi (n = 2098), Namibia (n = 27,382), and Eswatini (n = 2762). Using R version 4.2, we analysed the uptake and correlates of harmful alcohol consumption in SSA. The cutoff point for statistically significant was P<0.05.

Results
Of the 12,460 persons, 15% used alcohol harmfully. Harmful alcohol use varied by countries and ranged from 8.7% in Malawi to 26.1% in Namibia (P<0.001). Being female or HIV-positive and on ART were associated with less-likelihood of harmful alcohol consumption however persons that were HIV-positive and not on ART was associated with higher likelihood of harmful alcohol use (OR = 1.49, 95% CI: 1.32–1.69, P<0.001). The best performing models were Lasso or Super Learner or Random Forest were the best performing models while gradient boosting models or sample mean did not perform well.

Conclusion
Harmful alcohol use was high. Harmful alcohol use varied by countries, sex, age, HIV/ART status and marital status. Therefore, there is a need to introduce or enforce harmful alcohol use control policies in SSA through taking into account these characteristics.
Visual Endoscopic Retrograde Appendicitis Therapy Vs Antibiotic Therapy for Treatment of Uncomplicated Acute Appendicitis
Authors: Zhan Ke , Bai Yang , Liu Tianyu , Su Xing , Yang Qingqing , Liu Yang , Zhou Xiangrong , Zhang Yichuan , Tang Jianhua , Jiang Zheng , Yang Xin , Liu Weihui 
Published: October 2024

INTRODUCTION:
Visual endoscopic retrograde appendicitis therapy (V-ERAT) involves a single-use video scope, allowing for real-time visualization of the appendiceal lumen during the procedure to treat uncomplicated acute appendicitis (AA). This study aims to compare V-ERAT to antibiotic therapy in treating uncomplicated AA.

METHODS:
This multicenter, retrospective cohort study was conducted at 9 hospitals in China from August 2021 to July 2023. Propensity score matching was performed to minimize selection bias. A total of 692 uncomplicated AA patients were included, with 188 undergoing V-ERAT and 504 receiving antibiotic therapy. The primary outcome was treatment success rate. The secondary outcomes included recurrent appendicitis rate, the appendectomy rate during the initial hospitalization, length of initial hospitalization, time to disease recurrence, and overall adverse events.

RESULTS:
The treatment success rate did not differ between the V-ERAT and antibiotic groups (93.6%; 95% confidence interval [CI] 89.1%–96.7% vs 90.5%; 95% CI, 87.6%–92.9%) (P = 0.225). However, V-ERAT demonstrated a significantly lower risk of appendicitis recurrence compared with antibiotic therapy during the follow-up (log-rank P < 0.001), with a hazard ratio of 0.14 (95% CI, 0.07–0.29, P < 0.001). V-ERAT was associated with a lower appendectomy rate during the initial hospitalization (4.3%; 95% CI, 1.9%–8.2% vs 9.5%; 95% CI, 7.1%–12.4%) (P = 0.027), a shorter length of initial hospitalization (3 [interquartile range (IQR), 3–4] vs 4 [IQR, 4–6] days, P < 0.001), and a longer time to recurrence (269 [IQR, 210–318] vs 70 [IQR, 21–103] days, P < 0.001). The overall adverse event rates did not differ between the 2 groups (log-rank P = 0.064).

DISCUSSION:
V-ERAT seems to be a safe and effective alternative to antibiotic therapy in treating uncomplicated AA, significantly reducing the risk of appendicitis recurrence.
Phyto-mediated synthesis of ZnO nanoparticles and their sunlight-driven photocatalytic degradation of cationic and anionic dyes
Authors: Abduh Naaser A. Y. , Al-Kahtani Abdullah , Al-Odayni Abdel-Basit 
Published: October 2024

Abstract
In this study, zinc oxide-based nanocatalysts were biosynthesized using Ocimum basilicum (OB) and Olea africana (OA) leaf aqueous extracts, termed OB-ZnO and OA-ZnO, as a simple, affordable, and environmentally friendly approach. Their characteristics and efficacy in photodegrading cationic dyes (crystal violet and methylene blue) and anionic dyes (methyl orange and naphthol blue black) were investigated. The catalyst’s properties were analyzed using various techniques, including Fourier transform infrared, X-ray diffraction, photoluminescence, thermogravimetric analysis, UV-Vis, transmission electron microscopy, energy-dispersive X-ray spectroscopy, and Brunauer–Emmett–Teller. Analysis revealed pure products having a hexagonal wurtzite structure, crystallite sizes of 15.04 and 21.46 nm, surface areas of 23.65 and 7.97 m2/g, particle sizes of 35 and 170 nm with spherical (uniform) and oval-like (non-uniform) shapes, and optical bandgaps of 3.15 and 3.05 eV, respectively. Photocatalytic applications under sunlight indicated excellent activity of both catalysts against targeted cationic and anionic dyes. Most notably, even though OA-ZnO has a lower surface area than OB-ZnO, it demonstrated greater efficiency. The variation in effectiveness is explained by the lower bandgap value of OA-ZnO and its ability to reduce electron–hole recombination due to its larger crystal size, which accelerates the degradation process. Additionally, both catalysts exhibited high stability after being used four times.
The Ark of the Covenant’s Spelling Controversy: A Historical Linguistic Perspective
Authors: van Putten Marijn 
Published: October 2024

Abstract
This article examines a famous element in the reports on the canonization of the Qurʾānic text under the auspices of Uthman, in which the committee of scribes that were to write the standard text came to a disagreement on how to write the Qurʾānic word for at-tābūt “Ark.” After examining the different versions of the report that contain this episode, and concluding that the report of this episode goes back to the common link of Ibn Šihāb al-Zuhrī (d. 124/741–2), it is shown that early on the linguistic details of this disagreement were no longer understood. However, by examining how Aramaic and Classical Ethiopic loanwords that end in stem-final -ūt or -ōt are treated, this report can be understood as referring to two competing adaptations of this foreign word into Arabic. On the one hand at-tābūt, the form that ends up in the standard text, and on the other hand at-tābāh (or more precisely: at-tābōh), which shows a similar strategy of adaptation as several other central loanwords in the Qurʾān such as aṣ-ṣalāh “prayer” and az-zakāh “alms.”
“Superiority is due to us, and the king should come from among us”: The Arab Conquests and Conflicts of the Early Umayyad Era in a 7th-Century Syriac Universal History of Yoḥannān bar Penkāyē
Authors: Furman Yulia , Cherkashin Dmitry 
Published: October 2024

Abstract
The last few decades have seen considerable interest in non-Muslim sources that contain material on the earliest stage of Islam. This paper examines one such witness, The Book of the Main Points by Yoḥannān bar Penkāyē, a 7th-century Syriac universal history, that provides an account of the Arab conquests, the first decades of the Umayyad caliphate, with a special focus on the events of the Second Fitna. The paper includes a commentary on selected passages from the History concerning the conquests and early Muslim rule, a comparative study of Syriac Christian sources on the Second Fitna, and a lexico-historical sketch of the phenomenon of the šurṭa (slaves and prisoners of war) fighting on the side of al-Muḫtār during the Second Fitna.
Optimization of vehicle crashworthiness problems using recent twelve metaheuristic algorithms
Authors: Kumar Sumit , Yildiz Betul Sultan , Mehta Pranav , Sait Sadiq M. , Hussien Abdelazim G. , Yildiz Ali Riza 
Published: October 2024

Abstract
In recent years, numerous optimizers have emerged and been applied to address engineering design challenges. However, assessing their performance becomes increasingly challenging with growing problem complexity, especially in the realm of real-world large-scale applications. This study aims to fill this gap by conducting a comprehensive comparative analysis of twelve recently introduced metaheuristic optimizers. The analysis encompasses real-world scenarios to evaluate their effectiveness. Initially, a review was conducted on twelve prevalent metaheuristic methodologies to understand their behavior. These algorithms were applied to optimize an automobile structural design, focusing on minimizing vehicle weight while enhancing crash and noise, vibration, and harshness characteristics. To approximate the structural responses, a surrogate model employing radial basis functions was utilized. Notably, the MPA algorithm excelled in automobile design problems, achieving the lowest mass value of 96.90608 kg during both mid-range and long-range iterations, demonstrating exceptional convergence behavior.
Reinforcement of recycled polypropylene by nano lanthana with improved thermal, mechanical and antimicrobial properties
Authors: Ramakoti Ivaturi Siva , Panda Achyut Kumar , Jal Soumya , Gouda Narayan 
Published: October 2024

Abstract
In this study, lanthanum oxide (La2O3) nanoparticles or lanthana were synthesized by the planetary ball milling method and then used as a filler for the preparation of the polypropylene (PP) based nanocomposites by solution mixing method. The PP used in the study was derived from the discarded saline bottles. The structural and the surface morphology of the synthesized lanthanum oxide nanoparticles were characterized by XRD, SEM and FTIR. The thermogravimetric analysis (TGA) study revealed that the thermal stability of the nano lanthana composites increased with the addition of the lanthanum oxide nanoparticles. The mechanical properties, such as Young’s modulus and tensile strength, were also improved by the addition of the lanthanum oxide nanoparticles to the PP matrix. The composites also showed antibacterial activity against Escherichia coli bacteria. This approach not only mitigates medical plastic waste and environmental impact but also paves the way for versatile polymer nanocomposites with extensive industrial applications, especially in biomedical packaging.
A Geometric Model of Elections in Five Federal Democracies
Authors: Heggen Richard J. , Cuzán Alfred G. 
Published: October 2024

Abstract
In an analysis of 1,825 state or provincial election outcomes in five federal democracies the rate of decay of incumbency (K) serves to partition the distribution of the vote for the incumbent party, the party of the head of government, between those who win a subsequent term and those who do not. In conjunction with the mean and standard deviation of the distribution, the weighted mean of the vote in re-election and defeat is identified. The model’s predictions are generally within 2–3 percentage points of the actual outcome.