bluuebunny/crossref_metadata_2025_split huggingface dataset:
Milk vitamin D in relation to the ‘adequate intake’ for 0–6-month-old infants: a study in lactating women with different cultural backgrounds, living at different latitudes
Authors: Stoutjesdijk Eline , Schaafsma Anne , Nhien Nguyen V. , Khor Geok Lin , Kema Ido P. , Hollis Bruce W. , Dijck-Brouwer D. A. Janneke , Muskiet Frits A. J. 
Published: November 2017

AbstractBreast-fed infants are susceptible to vitamin D deficiency rickets. The current vitamin D ‘adequate intake’ (AI) for 0–6-month-old infants is 10 µg/d, corresponding with a human milk antirachitic activity (ARA) of 513 IU/l. We were particularly interested to see whether milk ARA of mothers with lifetime abundant sunlight exposure reaches the AI. We measured milk ARA of lactating mothers with different cultural backgrounds, living at different latitudes. Mature milk was derived from 181 lactating women in the Netherlands, Curaçao, Vietnam, Malaysia and Tanzania. Milk ARA and plasma 25-hydroxyvitamin D (25(OH)D) were analysed by liquid-chromatography-MS/MS; milk fatty acids were analysed by GC-flame ionisation detector (FID). None of the mothers reached the milk vitamin D AI. Milk ARA (n; median; range) were as follows: Netherlands (n 9; 46 IU/l; 3–51), Curaçao (n 10; 31 IU/l; 5–113), Vietnam: Halong Bay (n 20; 58 IU/l; 23–110), Phu Tho (n 22; 28 IU/l; 1–62), Tien Giang (n 20; 63 IU/l; 26–247), Ho-Chi-Minh-City (n 18; 49 IU/l; 24–116), Hanoi (n 21; 37 IU/l; 11–118), Malaysia–Kuala Lumpur (n 20; 14 IU/l; 1–46) and Tanzania-Ukerewe (n 21; 77 IU/l; 12–232) and Maasai (n 20; 88 IU/l; 43–189). We collected blood samples of these lactating women in Curaçao, Vietnam and from Tanzania–Ukerewe, and found that 33·3 % had plasma 25(OH)D levels between 80 and 249·9 nmol/l, 47·3 % between 50 and 79·9 nmol/l and 19·4 % between 25 and 49·9 nmol/l. Milk ARA correlated positively with maternal plasma 25(OH)D (range 27–132 nmol/l, r 0·40) and milk EPA+DHA (0·1–3·1 g%, r 0·20), and negatively with latitude (2°S-53°N, r −0·21). Milk ARA of mothers with lifetime abundant sunlight exposure is not even close to the vitamin D AI for 0–6-month-old infants. Our data may point at the importance of adequate fetal vitamin D stores.
Evil and the God of Abraham, Anselm, and Murphy
Authors: DRAPER PAUL 
Published: November 2017

AbstractMark Murphy's attempt to solve the problem of evil appeals to the hypothesis, which I call ‘Murphy's hypothesis’, that an Anselmian God only has justifying reasons and not requiring reasons to promote the well-being of Her sentient creatures. Given this hypothesis, the distribution of benefits and harms that we observe in the world is not unexpected on Anselmian theism. I argue that Murphy fails to solve the problem of evil for two reasons. First, he incorrectly equates the probability of the distribution of benefits and harms given theism with the probability of that distribution given theism conjoined with Murphy's hypothesis. Second, he fails to solve the evidential problem of immorality for Christian Anselmian theists and in fact his views make that problem significantly worse.
Intrinsic value and love: three challenges for God's Own Ethics
Authors: WIELENBERG ERIK J. 
Published: November 2017

AbstractI advance three challenges for the view Murphy advances in God's Own Ethics. The first two challenges target Murphy's claim that God does not have requiring reasons to prevent the suffering of rational creatures. I develop two arguments against that position, one based on the intrinsic value of human beings, the other based on the intrinsic badness of the suffering of rational creatures. My third challenge targets Murphy's account of God's contingent love for humanity. I seek to raise doubts about whether Murphy's picture is one in which it is true to say that God loves all human beings.
Applications of differential subordinations for norm estimates of an integral operator
Authors: Dziok Jacek , Raina Ravinder Krishna , Sokół Janusz 
Published: November 2017

By considering the norm of a locally univalent function given bywe obtain such norm estimates for an operator of functions involving a convolution structure of convex univalent functions with a subclass of convex functions (defined by subordination). We also obtain some inequalities concerning this norm for functions under a certain fractional integral operator. Some implications of our results are briefly pointed out in the concluding section.
Improving maternal, infant and young child nutrition in Nepal via peer mobilization
Authors: Singh Akriti , Klemm Rolf DW , Mundy Gary , Pandey Rana Pooja , Pun Bhim , Cunningham Kenda 
Published: November 2017

AbstractObjectiveTo evaluate the impact of a peer facilitator (PF) approach for improving mothers’ knowledge and practices relating to maternal and child nutrition.DesignA quasi-experimental design nested within a large-scale integrated nutrition programme, Suaahara, in Nepal. Suaahara interventions were implemented in all study sites, but peer facilitators were used in only half of the study sites.SettingRural, disadvantaged villages in three districts of Nepal: Bhojpur, Bajhang and Rupandehi.SubjectsMothers of children aged 6–23·9 months (n 1890).ResultsDifferences over time between comparison (C) and intervention (I) groups show that the PF approach had a significant positive impact on several indicators of mothers’ knowledge and practices relating to maternal and child nutrition: (i) knowing that fruits and vegetables are good for children 6–23·9 months (C: −0·7, I: 10·6; P=0·03); (ii) child dietary diversity (C: 0·02, I: 0·04; P=0·02); (iii) child minimum dietary diversity (≥4 of 7 food groups; (C: 6·9, I: 16·0; P=0·02); (iv) maternal dietary diversity (C: 0·1, I: 0·4; P=0·01); and (v) maternal minimum dietary diversity (≥4 food groups; C: 3·6, I: 14·0; P=0·03). Additionally, exposure to a PF three or more times in the past 6 months was positively associated with a small improvement in maternal (β=0·06, P=0·04) and child (β=0·06, P=0·02) dietary diversity scores. Improvements were not observed in maternal health-seeking behaviours such as number of antenatal care visits.ConclusionsPeer mobilization is a potential approach for improving health- and nutrition-related knowledge and behaviours among women in hard-to-reach communities of Nepal.
Contracts and trust: complements or substitutes?
Authors: MCCANNON BRYAN C. , ASAAD COLLEEN TOKAR , WILSON MARK 
Published: November 2017

AbstractSocial preferences and third-party enforcement of formal contracts are two mechanisms that facilitate performance of an agreement. The standard argument is that formal, enforceable contracts substitute when the social preferences of trust and trustworthiness are lacking. We explore the alternative hypothesis that trust and contract enforcement are complements. We measure social preferences from both a Trust Game and a social values survey, using them as explanatory variables in a Contract Game. We find that both increased contract enforcement and high trusting preferences lead to enhanced rates of contract formation and larger investments. There is an important interaction effect, where trusting individuals enter into agreements at a greater rate and make larger investments when enforcement is greater. Thus, contracts and trust complement one another.
Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia
Authors: Peng F , Wang J-H , Fan W-J , Meng Y-T , Li M-M , Li T-T , Cui B , Wang H-F , Zhao Y , An F , Guo T , Liu X-F , Zhang L , Lv L , Lv D-K , Xu L-Z , Xie J-J , Lin W-X , Lam E W-F , Xu J , Liu Q 
Published: November 2017

Abstract
Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH+ subpopulations, decreases stemness-related transcriptional factor expression, and inhibits sphere-formation ability and tumor growth. Conversely, high levels of PDK1 enhance BCSC properties and are correlated with poor overall survival. In mouse xenograft tumor, PDK1 is accumulated in hypoxic regions and activates glycolysis to promote stem-like traits. Moreover, through screening hypoxia-related long non-coding RNAs (lncRNAs) in PDK1-positive tissue, we find that lncRNA H19 is responsible for glycolysis and BCSC maintenance. Furthermore, H19 knockdown decreases PDK1 expression in hypoxia, and ablation of PDK1 counteracts H19-mediated glycolysis and self-renewal ability in vitro and in vivo. Accordingly, H19 and PDK1 expression exhibits strong correlations in primary breast carcinomas. H19 acting as a competitive endogenous RNA sequesters miRNA let-7 to release Hypoxia-inducible factor 1α, leading to an increase in PDK1 expression. Lastly, aspirin markedly attenuates glycolysis and cancer stem-like characteristics by suppressing both H19 and PDK1. Thus, these novel findings demonstrate that the glycolysis gatekeeper PDK1 has a critical role in BCSC reprogramming and provides a potential therapeutic strategy for breast malignancy.
DNA methylation at enhancers identifies distinct breast cancer lineages
Authors: Fleischer Thomas , Tekpli Xavier , Mathelier Anthony , Wang Shixiong , Nebdal Daniel , Dhakal Hari P. , Sahlberg Kristine Kleivi , Schlichting Ellen ,   Oslo Breast Cancer Research Consortium (OSBREAC), Sauer Torill , Geisler Jürgen , Hofvind Solveig , Bathen Tone F , Engebraaten Olav , Garred Øystein , Geitvik Gry Aarum , Langerød Anita , Kåresen Rolf , Mælandsmo Gunhild Mari , Russnes Hege G , Sørlie Therese , Lingjærde Ole Christian , Skjerven Helle Kristine , Park Daehoon , Fritzman Britt , Børresen-Dale Anne-Lise , Borgen Elin , Naume Bjørn , Eskeland Ragnhild , Frigessi Arnoldo , Tost Jörg , Hurtado Antoni , Kristensen Vessela N. 
Published: November 2017

AbstractBreast cancers exhibit genome-wide aberrant DNA methylation patterns. To investigate how these affect the transcriptome and which changes are linked to transformation or progression, we apply genome-wide expression–methylation quantitative trait loci (emQTL) analysis between DNA methylation and gene expression. On a whole genome scale, in cis and in trans, DNA methylation and gene expression have remarkably and reproducibly conserved patterns of association in three breast cancer cohorts (n = 104, n = 253 and n = 277). The expression–methylation quantitative trait loci associations form two main clusters; one relates to tumor infiltrating immune cell signatures and the other to estrogen receptor signaling. In the estrogen related cluster, using ChromHMM segmentation and transcription factor chromatin immunoprecipitation sequencing data, we identify transcriptional networks regulated in a cell lineage-specific manner by DNA methylation at enhancers. These networks are strongly dominated by ERα, FOXA1 or GATA3 and their targets were functionally validated using knockdown by small interfering RNA or GRO-seq analysis after transcriptional stimulation with estrogen.
Multicolor lineage tracing reveals clonal architecture and dynamics in colon cancer
Authors: Lamprecht Sebastian , Schmidt Eva Marina , Blaj Cristina , Hermeking Heiko , Jung Andreas , Kirchner Thomas , Horst David 
Published: November 2017

AbstractColon cancers are composed of phenotypically heterogeneous tumor cell subpopulations with variable expression of putative stem cell and differentiation antigens. While in normal colonic mucosa, clonal repopulation occurs along differentiation gradients from crypt base toward crypt apex, the clonal architecture of colon cancer and the relevance of tumor cell subpopulations for clonal outgrowth are poorly understood. Using a multicolor lineage tracing approach in colon cancer xenografts that reflect primary colon cancer architecture, we here demonstrate that clonal outgrowth is mainly driven by tumor cells located at the leading tumor edge with clonal axis formation toward the tumor center. While our findings are compatible with lineage outgrowth in a cancer stem cell model, they suggest that in colorectal cancer tumor cell position may be more important for clonal outgrowth than tumor cell phenotype.
Organocatalytic enantio- and diastereoselective cycloetherification via dynamic kinetic resolution of chiral cyanohydrins
Authors: Yoneda Naoki , Fujii Yuki , Matsumoto Akira , Asano Keisuke , Matsubara Seijiro 
Published: November 2017

AbstractEnantioselective approaches to synthesize six-membered oxacycles with multiple stereogenic centres are in high demand to enable the discovery of new therapeutic agents. Here we present a concise organocatalytic cycloetherification for the highly enantio- and diastereoselective synthesis of tetrahydropyrans involving simultaneous construction of two chiral centres, one of which is fully substituted. This method involves dynamic kinetic resolution of reversibly generated chiral cyanohydrins. A chiral bifunctional organocatalyst selectively recognizes a specific chair-like conformation of the intermediate, in which the small steric effect of the linear cyano group as well as its anomeric effect play important roles in controlling stereoselectivity. The products offer additional utility as synthetic intermediates because the cyano group can be further transformed into a variety of important functional groups. This strategy provides a platform to design efficient approaches to obtain a wide range of optically active tetrahydropyrans, which are otherwise synthetically challenging materials.
KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression
Authors: Zhao Hongmei , Wang Xiaoshuang , Yi Ping , Si Yanmin , Tan Puwen , He Jinrong , Yu Shan , Ren Yue , Ma Yanni , Zhang Junwu , Wang Dong , Wang Fang , Yu Jia 
Published: November 2017

AbstractRNA-binding proteins (RBPs) integrate the processing of RNAs into post-transcriptional gene regulation, but the direct contribution of them to myeloid cell specification is poorly understood. Here, we report the first global RBP transcriptomic analysis of myeloid differentiation by combining RNA-seq analysis with myeloid induction in CD34+ hematopoietic progenitor cells. The downregulated expression of the KH-Type Splicing Regulatory Protein (KSRP) during monocytopoiesis and up-regulated expression during granulopoiesis suggests that KSRP has divergent roles during monocytic and granulocytic differentiation. A further comparative analysis of miRNA transcripts reveals that KSRP promotes the biogenesis of miR-129, and the expression patterns and roles of miR-129 in myeloid differentiation are equivalent to those of KSRP. Finally, miR-129 directly blocks the expression of Runt Related Transcription Factor 1 (RUNX1), which evokes transcriptional modulation by RUNX1. Based on our findings, KSRP, miR-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation.
Semisynthetic fluorescent pH sensors for imaging exocytosis and endocytosis
Authors: Martineau Magalie , Somasundaram Agila , Grimm Jonathan B. , Gruber Todd D. , Choquet Daniel , Taraska Justin W. , Lavis Luke D. , Perrais David 
Published: November 2017

AbstractThe GFP-based superecliptic pHluorin (SEP) enables detection of exocytosis and endocytosis, but its performance has not been duplicated in red fluorescent protein scaffolds. Here we describe “semisynthetic” pH-sensitive protein conjugates with organic fluorophores, carbofluorescein, and Virginia Orange that match the properties of SEP. Conjugation to genetically encoded self-labeling tags or antibodies allows visualization of both exocytosis and endocytosis, constituting new bright sensors for these key steps of synaptic transmission.
Orthogonal navigation of multiple visible-light-driven artificial microswimmers
Authors: Zheng Jing , Dai Baohu , Wang Jizhuang , Xiong Ze , Yang Ya , Liu Jun , Zhan Xiaojun , Wan Zhihan , Tang Jinyao 
Published: November 2017

AbstractNano/microswimmers represent the persistent endeavors of generations of scientists towards the ultimate tiny machinery for device manufacturing, targeted drug delivery, and noninvasive surgery. In many of these envisioned applications, multiple microswimmers need to be controlled independently and work cooperatively to perform a complex task. However, this multiple channel actuation remains a challenge as the controlling signal, usually a magnetic or electric field, is applied globally over all microswimmers, which makes it difficult to decouple the responses of multiple microswimmers. Here, we demonstrate that a photoelectrochemically driven nanotree microswimmer can be easily coded with a distinct spectral response by loading it with dyes. By using different dyes, an individual microswimmer can be controlled and navigated independently of other microswimmers in a group. This development demonstrates the excellent flexibility of the light navigation method and paves the way for the development of more functional nanobots for applications that require high-level controllability.
Coculture of meniscus cells and mesenchymal stem cells in simulated microgravity
Authors: Weiss William M. , Mulet-Sierra Aillette , Kunze Melanie , Jomha Nadr M. , Adesida Adetola B. 
Published: November 2017

AbstractSimulated microgravity has been shown to enhance cartilaginous matrix formation by chondrocytes and chondrogenesis of mesenchymal stem cells (MSCs). Similarly, coculture of primary chondrocytes with MSCs has been shown as a strategy to simultaneously retain the differentiated phenotype of chondrocytes and enhance cartilaginous matrix formation. In this study, we investigated the effect of simulated microgravity on cocultures of primary human meniscus cells and adipose-derived MSCs. We used biochemical, qPCR, and immunofluorescence assays to conduct our investigation. Simulated microgravity significantly enhanced cartilaginous matrix formation in cocultures of primary meniscus cells and adipose-derived MSCs. The enhancement was accompanied by increased hypertrophic differentiation markers,COL10A1andMMP-13, and suppression of hypertrophic differentiation inhibitor, gremlin 1 (GREM1).
Food for thought: how nutrition impacts cognition and emotion
Authors: Spencer Sarah J. , Korosi Aniko , Layé Sophie , Shukitt-Hale Barbara , Barrientos Ruth M. 
Published: November 2017

AbstractMore than one-third of American adults are obese and statistics are similar worldwide. Caloric intake and diet composition have large and lasting effects on cognition and emotion, especially during critical periods in development, but the neural mechanisms for these effects are not well understood. A clear understanding of the cognitive–emotional processes underpinning desires to over-consume foods can assist more effective prevention and treatments of obesity. This review addresses recent work linking dietary fat intake and omega-3 polyunsaturated fatty acid dietary imbalance with inflammation in developing, adult, and aged brains. Thus, early-life diet and exposure to stress can lead to cognitive dysfunction throughout life and there is potential for early nutritional interventions (e.g., with essential micronutrients) for preventing these deficits. Likewise, acute consumption of a high-fat diet primes the hippocampus to produce a potentiated neuroinflammatory response to a mild immune challenge, causing memory deficits. Low dietary intake of omega-3 polyunsaturated fatty acids can also contribute to depression through its effects on endocannabinoid and inflammatory pathways in specific brain regions leading to synaptic phagocytosis by microglia in the hippocampus, contributing to memory loss. However, encouragingly, consumption of fruits and vegetables high in polyphenolics can prevent and even reverse age-related cognitive deficits by lowering oxidative stress and inflammation. Understanding relationships between diet, cognition, and emotion is necessary to uncover mechanisms involved in and strategies to prevent or attenuate comorbid neurological conditions in obese individuals.
Lensless Photoluminescence Hyperspectral Camera Employing Random Speckle Patterns
Authors: Žídek Karel , Denk Ondřej , Hlubuček Jiří 
Published: November 2017

AbstractWe propose and demonstrate a spectrally-resolved photoluminescence imaging setup based on the so-called single pixel camera – a technique of compressive sensing, which enables imaging by using a single-pixel photodetector. The method relies on encoding an image by a series of random patterns. In our approach, the image encoding was maintained via laser speckle patterns generated by an excitation laser beam scattered on a diffusor. By using a spectrometer as the single-pixel detector we attained a realization of a spectrally-resolved photoluminescence camera with unmatched simplicity. We present reconstructed hyperspectral images of several model scenes. We also discuss parameters affecting the imaging quality, such as the correlation degree of speckle patterns, pattern fineness, and number of datapoints. Finally, we compare the presented technique to hyperspectral imaging using sample scanning. The presented method enables photoluminescence imaging for a broad range of coherent excitation sources and detection spectral areas.
Femtosecond time-resolved observation of butterfly vibration in electronically excited o-fluorophenol
Authors: Ling Fengzi , Li Shuai , Song Xinli , Wang Yanmei , Long Jinyou , Zhang Bing 
Published: November 2017

AbstractThe butterfly vibration during the hydrogen tunneling process in electronically excited o-fluorophenol has been visualized in real time by femtosecond time-resolved ion yield spectroscopy coupled with time-resolved photoelectron imaging technique. A coherent superposition of out-of-plane C–F butterfly motions is prepared in the first excited electronic state (S1). As the C–F bond vibrates with respect to the aromatic ring, the nuclear geometry varies periodically, leading to the corresponding variation in the photoionization channel. By virtue of the more favorable ionization probability from the nonplanar minimum via resonance with the Rydberg states, the evolution of the vibrational wave packet is manifested as a superimposed beat in the parent-ion transient. Moreover, time-resolved photoelectron spectra offer a direct mapping of the oscillating butterfly vibration between the planar geometry and nonplanar minimum. The beats for the photoelectron peaks originating from the planar geometry are out of phase with those from the nonplanar minimum. Our results provide a physically intuitive and complete picture of the oscillatory flow of energy responsible for the coherent vibrational motion on the excited state surface.