bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’incertitude menaçante qui pèse sur les mineurs isolés étrangers : conséquences psychologiques
Authors: Woestelandt Laure , Radjack Rahmethnissah , Touhami Fatima , Moro Marie Rose 
Published: June 2016

Qui sont les mineurs étrangers isolés ? Les motivations qui déterminent chacun de leur départ sont complexes et multiples : à côté des départs volontaires pour étudier, travailler, approcher un idéal, d’autres fuient guerres, dictatures et catastrophes climatiques... Après avoir décrit la population variée des mineurs isolés étrangers et les problématiques qui la caractérisent, nous discuterons les triples aspects légaux, sociaux et psychologiques qui sous-tendent l’accompagnement de ces jeunes. Nous soulignons notamment le caractère paradoxal des injonctions qui leur sont demandées, et qui accentue le sentiment d’insécurité de ces jeunes.
Langue et confession
Authors: Hajji Ali 
Published: June 2016

Nous nous proposons d’étudier un aspect essentiel de l’identité des chiites, la langue. Nous nous attacherons, ici, à en relever les caractéristiques religieuses en montrant plus précisément comment les chiites se distinguent, du point de vue linguistique, de leurs compatriotes sunnites au Koweït. Pour ce faire, une analyse lexicale sera nécessaire et celle-ci sera replacée dans un contexte historique et social propre aux populations chiites du Koweït. Ces caractéristiques sont donc soulignées sur trois niveaux : lexical, diachronique et synchronique. Une enquête de terrain nous a en effet permis de recueillir le corpus nécessaire à notre analyse, issu de différents informateurs appartenant à des catégories sociales différentes. Cette étude lance des pistes permettant de mettre en évidence l’altérité d’une société multiculturelle comme celle du Koweït, malgré son apparente homogénéité.
Quand les cancers du travail échappent à la reconnaissance
Authors: Marchand Anne 
Published: June 2016

Le risque cancérogène au travail demeure encore largement sous-estimé. Selon plusieurs rapports administratifs, les (anciens) salariés en seraient responsables, pour une part, faute de recourir au droit à réparation en maladie professionnelle. À partir d’une enquête de terrain menée en Seine-Saint-Denis auprès de patients atteints de cancer du poumon, cet article précise les différents mécanismes qui font obstacle au recours au droit : l’information sur le droit ne suffit pas, il faut aussi que les formes de la réparation prennent sens, et ce dans un contexte de maladie grave et mortelle. La gestion purement assurantielle de dossiers individuels apparaît ainsi en complet décalage avec les objectifs de « réparation » des personnes empoisonnées au travail.
FAT10 Is Critical in Influenza A Virus Replication by Inhibiting Type I IFN
Authors: Zhang Yanli , Tang Jun , Yang Ning , Liu Qiang , Zhang Qingchao , Zhang Yanxu , Li Ning , Zhao Yan , Li Shunwang , Liu Song , Zhou Huandi , Li Xiao , Tian Mingyao , Deng Jiejie , Xie Peng , Sun Yang , Lu Huijun , Zhang Michael Q. , Jin Ningyi , Jiang Chengyu 
Published: June 2016

Abstract
The H5N1 avian influenza virus causes severe disease and high mortality, making it a major public health concern worldwide. The virus uses the host cellular machinery for several steps of its life cycle. In this report, we observed overexpression of the ubiquitin-like protein FAT10 following live H5N1 virus infection in BALB/c mice and in the human respiratory epithelial cell lines A549 and BEAS-2B. Further experiments demonstrated that FAT10 increased H5N1 virus replication and decreased the viability of infected cells. Total RNA extracted from H5N1 virus–infected cells, but not other H5N1 viral components, upregulated FAT10, and this process was mediated by the retinoic acid–induced protein I-NF-κB signaling pathway. FAT10 knockdown in A549 cells upregulated type I IFN mRNA expression and enhanced STAT1 phosphorylation during live H5N1 virus infection. Taken together, our data suggest that FAT10 was upregulated via retinoic acid–induced protein I and NF-κB during H5N1 avian influenza virus infection. And the upregulated FAT10 promoted H5N1 viral replication by inhibiting type I IFN.
An appropriately performed conventional blood culture can facilitate choice of therapy in resource-constrained settings-comparison with BACTEC 9050
Authors: Surase PV , Nataraj G , Pattamadai K , Mehta PR , Pazare AR , Agarwal MC , Nanavati RN 
Published: June 2016

Aims:
Comparison of conventional blood culture with BACTEC 9050 for rate and time to detection of microorganisms.

Settings and Design:
A prospective study was carried out in a multispecialty tertiary care teaching hospital.

Subjects and Methods:
A total of 835 paired specimens (797 blood and 38 nonblood specimens) were collected and processed according to standard microbiological procedures by both conventional method as well as by BACTEC 9050 automated culture system. Clinical details of patients were recorded. Data were analyzed for time to detection and isolation rate by the two systems and compared.

Results:
Overall culture positivity for BACTEC 9050 and the conventional system was 32% and 19.88%, respectively. Eighty-five demonstrated concordant growth, 136 specimens were culture positive by BACTEC only, and 38 specimens were culture positive by conventional only. Twelve contaminants in BACTEC and nine contaminants in conventional system were detected. Using BACTEC 9050, higher isolation was observed for Acinetobacter spp., coagulase negative Staphylococcus spp., Streptococcus spp., and Candida spp. A total of 410 patients were on antimicrobial treatment and culture positivity was significantly higher with BACTEC 9050 (P < 0.0001). There was a significant difference in the mean time to detection with BACTEC 9050 recovering 86.8% of isolates within 48 h (P < 0.0001).

Conclusions:
Although BACTEC 9050 demonstrated a significantly higher recovery of microorganisms from blood, an appropriately performed conventional blood culture can facilitate the choice of therapy.
Subgroup Analyses from a Phase 3, Open-Label, Randomized Study of Eribulin Mesylate versus Capecitabine in Pretreated Patients with Advanced or Metastatic Breast Cancer
Authors: Twelves Chris , Awada Ahmad , Cortes Javier , Yelle Louise , Velikova Galina , Olivo Martin S. , Song James , Dutcus Corina E. , Kaufman Peter A. 
Published: June 2016

Purpose and Methods Our secondary analyses compared survival with eribulin versus capecitabine in various patient subgroups from a phase 3, open-label, randomized study. Eligible women aged ≥18 years with advanced/metastatic breast cancer and ≤3 prior chemotherapies (≤2 for advanced/metastatic disease), including an anthracycline and taxane, were randomized 1:1 to intravenous eribulin mesylate 1.4 mg/m2 on days 1 and 8 or twice-daily oral capecitabine 1250 mg/m2 on days 1–14 (21-day cycles). Results In the intent-to-treat population (eribulin 554 and capecitabine 548), overall survival appeared longer with eribulin than capecitabine in various subgroups, including patients with human epidermal growth factor receptor 2-negative (15.9 versus 13.5 months, respectively), estrogen receptor-negative (14.4 versus 10.5 months, respectively), and triple-negative (14.4 versus 9.4 months, respectively) disease. Progression-free survival was similar between the treatment arms. Conclusions Patients with advanced/metastatic breast cancer and human epidermal growth factor receptor 2-, estrogen receptor-, or triple-negative disease may gain particular benefit from eribulin as first-, second-, and third-line chemotherapies. Trial Registration (Primary Study) This study reports the subgroup analyses of eribulin versus capecitabine from a phase 3, open-label, randomized study ( www.clinicaltrials.gov ; ClinicalTrials.gov identifier: NCT00337103).
Optimized Computerized Order Entry can Reduce Errors in Electronic Prescriptions and Associated Pharmacy Calls to Clarify (CTC)
Authors: Ogletree Richard , Sutterfield Allison , Pace John , Lahr Laurene , Patel Jaimin 
Published: June 2016

SummaryAfter implementation of a system-wide EMR within our university system, e-prescribing is now commonplace.The authors conducted a study to assess whether optimization of computerized provider order entry (CPOE) can reduce errors in these electronically transmitted prescriptions and would require less frequent interventions from pharmacists, in particular the need for them to “call to clarify” (CTC) details of particular prescriptions. Secondary analysis based on cost assumptions was preformed to presume cost differences before and after optimization changes.In order to generate complete, error-free prescriptions, optimization changes were implemented in the form of in line validation messages. These messages were generated if (1) an order did not specify a provider or pharmacy; (2) the DEA requirements were not met; (3) character limits were exceeded in patient sig or demographics or (4) administration instructions had breaks or had both discrete and free text elements. Retrospectively, prescriptions were randomly selected from a nine month period before and after implementing changes. These prescriptions were analyzed by a pharmacist and a nurse to identify types of errors that would require a CTC to a prescribing provider. Errors were compared statistically to determine effectiveness of changes pre and post optimization.A total of 602 prescriptions were analyzed; 301 before changes and 301 after changes. Of these prescriptions, 20.27% had errors before changes and 12.96% had errors after changes. The decline in the error rate was considered statistically significant for p<0.05. The cost savings were estimated at $76 per 100 prescriptions for pharmacist and physician time-cost estimates combined.Implementing optimization changes to the CPOE resulted in a reduction in error rate requiring pharmacist CTC. This study identifies effective optimization changes for electronic prescribing that can reduce prescribing errors and may result in cost saving.
Rethinking the global secondary organic aerosol (SOA) budget: stronger production, faster removal, shorter lifetime
Authors: Hodzic Alma , Kasibhatla Prasad S. , Jo Duseong S. , Cappa Christopher D. , Jimenez Jose L. , Madronich Sasha , Park Rokjin J. 
Published: June 2016

Abstract. Recent laboratory studies suggest that secondary organic aerosol (SOA) formation rates are higher than assumed in current models. There is also evidence that SOA removal by dry and wet deposition occurs more efficiently than some current models suggest and that photolysis and heterogeneous oxidation may be important (but currently ignored) SOA sinks. Here, we have updated the global GEOS-Chem model to include this new information on formation (i.e., wall-corrected yields and emissions of semi-volatile and intermediate volatility organic compounds) and on removal processes (photolysis and heterogeneous oxidation). We compare simulated SOA from various model configurations against ground, aircraft and satellite measurements to assess the extent to which these improved representations of SOA formation and removal processes are consistent with observed characteristics of the SOA distribution. The updated model presents a more dynamic picture of the life cycle of atmospheric SOA, with production rates 3.9 times higher and sinks a factor of 3.6 more efficient than in the base model. In particular, the updated model predicts larger SOA concentrations in the boundary layer and lower concentrations in the upper troposphere, leading to better agreement with surface and aircraft measurements of organic aerosol compared to the base model. Our analysis thus suggests that the long-standing discrepancy in model predictions of the vertical SOA distribution can now be resolved, at least in part, by a stronger source and stronger sinks leading to a shorter lifetime. The predicted global SOA burden in the updated model is 0.88 Tg and the corresponding direct radiative effect at top of the atmosphere is −0.33 W m−2, which is comparable to recent model estimates constrained by observations. The updated model predicts a population-weighed global mean surface SOA concentration that is a factor of 2 higher than in the base model, suggesting the need for a reanalysis of the contribution of SOA to PM pollution-related human health effects. The potential importance of our estimates highlights the need for more extensive field and laboratory studies focused on characterizing organic aerosol removal mechanisms and rates.
A miniDOAS instrument optimised for ammonia field measurements
Authors: Sintermann Jörg , Dietrich Klaus , Häni Christoph , Bell Michael , Jocher Markus , Neftel Albrecht 
Published: June 2016

Abstract. We present a differential optical absorption spectroscopy (DOAS) instrument, called "miniDOAS", optimised for optical open-path field-measurements of ambient ammonia (NH3) alongside nitrogen oxide (NO) and sulfur dioxide (SO2). The instrument is a further development of the miniDOAS presented by Volten et al. (2012). We use a temperature-controlled spectrometer, a deuterium light source and a modified optical arrangement. The system was set up in a robust, field-deployable, temperature-regulated housing. For the evaluation of light spectra we use a new high-pass filter routine based upon robust baseline extraction with local regression. Multiple linear regression including terms of an autoregressive–moving-average model is used to determine concentrations. For NH3 the random uncertainty is about 1.4 % of the concentration, and not better than 0.2 µg m−3. Potential biases for the slope of the calibration are given by the precision of the differential absorption cross sections (±3 %) and for the offset by the precision of the estimation of concentration offsets (cref) introduced by the reference spectrum Iref. Comparisons of miniDOAS measurements to those by NH3 acid trap devices showed good agreement. The miniDOAS can be flexibly used for a wide range of field trials, such as micrometeorological NH3 flux measurements with approaches based upon horizontal or vertical concentration differences. Results from such applications covering concentration dynamics of less than one up to several hundreds of µg m−3 are presented.
Basal buoyancy and fast-moving glaciers: in defense of analytic force balance
Authors: van der Veen C. J. 
Published: June 2016

Abstract. The geometric approach to force balance advocated by T. Hughes in a series of publications has challenged the analytic approach by implying that the latter does not adequately account for basal buoyancy on ice streams, thereby neglecting the contribution to the gravitational driving force associated with this basal buoyancy. Application of the geometric approach to Byrd Glacier, Antarctica, yields physically unrealistic results, and it is argued that this is because of a key limiting assumption in the geometric approach. A more traditional analytic treatment of force balance shows that basal buoyancy does not affect the balance of forces on ice streams, except locally perhaps, through bridging effects.
Are Improvements Maintained After In-home Pulmonary Telerehabilitation for Patients with Chronic Obstructive Pulmonary Disease?
Authors: Marquis Nicole , Larivée Pierre , Dubois Marie-France , Tousignant Michel 
Published: June 2016

This study investigated if improvements can be maintained over 24 weeks when in-home pulmonary telerehabilitation is combined with asynchronous self-management education for Chronic Obstructive Pulmonary Disease (COPD). Twenty-three community-living elders with moderate to very severe COPD participated in a pre/post-intervention study. Over 8 weeks, they had access to self-learning capsules on self-management, received 15 in-home teletreatment sessions and were encouraged to gradually engage in unsupervised sessions. Participants were assessed before the intervention (T1), immediately after the intervention (T2), and 6 months later (T3). Outcome measures were 1) exercise tolerance (6-minute walk test [6MWT]), Cycle Endurance Test [CET]), and 2) quality of life (Chronic Respiratory Questionnaire [CRQ]). Although there were significant improvements after 8 weeks of pulmonary telerehabilitation on the 6MWT, CET and three of four CRQ domains, none of these improvements were maintained after 6 months and scores returned to their baseline values (all p values > 0.05 when comparing T3 with T1). While pulmonary telerehabilitation is possible and has a positive impact on patients with moderate to very severe COPD, improvements were not maintained in the long-term even when physical therapy was accompanied by self-management education.
Combining Teletherapy and On-line Language Exercises in the Treatment of Chronic Aphasia: An Outcome Study
Authors: Steele Richard D. , Baird Allison , McCall Denise , Haynes Lisa 
Published: June 2016

We report a 12-week outcome study in which nine persons with long-term chronic aphasia received individual and group speech-language teletherapy services, and also used on-line language exercises to practice from home between therapy sessions. Participants were assessed at study initiation and completion using the Western Aphasia Battery, a portion of the Communicative Effectiveness Index, ASHA National Outcome Measurement System, and RIC Communication Confidence Rating Scale for Aphasia; additionally participants were polled regarding satisfaction at discharge. Pre-treatment and post-treatment means were calculated and compared, and matched t-tests were used to determine significance of improvements following treatment, with patterns of independent on-line activity analyzed. Analysis of scores shows that means improved on most measures following treatment, generally significantly: the WAB AQ improved +3.5 (p = .057); the CETI Overall (of items administered) — +17.8 (p = .01), and CCRSA Overall — + 10.4 (p = .0004). Independent work increased with time, and user satisfaction following participation was high.
CARGANO, Fabiane Baran. A comunidade de software livre e de código aberto nas redes sociotécnicas: controvérsias tecnocientíficas e reabertura da caixa preta. Curitiba: Mestrado em Sociologia da UFPR, 2011, 151p.
Authors: Heimoski Ricardo 
Published: June 2016

CARGANO, Fabiane Baran. A comunidade de software livre e de código aberto nas redes sociotécnicas: controvérsias tecnocientíficas e reabertura da caixa preta. Curitiba: Mestrado em Sociologia da UFPR, 2011, 151p.
Defining desirable natural product derived anticancer drug space: optimization of molecular physicochemical properties and ADMET attributes
Authors: Singh Deepika 
Published: June 2016

<p class="ADMETabstracttext">As part of our endeavor to enhance survival of natural product derived drug candidates and to guide the medicinal chemist to design higher probability space for success in the anti cancer drug development area, we embarked on a detailed study of the property space for a collection of natural product derived anti cancer molecules. We carried out a comprehensive analysis of properties for 24 natural products derived anti cancer drugs including clinical development candidates and a set of 27 natural products derived anti cancer lead compounds. In particular, we focused on understanding the interplay among eight physicochemical properties including like partition coefficient (log P), distribution coefficient at pH=7.4 (log D), topological polar surface area (TPSA), molecular weight (MW), aqueous solubility (log S), number of hydrogen bond acceptors (HBA), number of hydrogen bond donors (HBD) and number of rotatable bonds (n<sub>Rot</sub>) crucial for drug design and relationships between physicochemical properties, ADME (absorption, distribution, metabolism, and elimination) attributes, and in silico toxicity profile for these two sets of compounds. This analysis provides guidance for the chemist to modify the existing natural product scaffold or designing of new anti cancer molecules in a property space with increased probability of success and may lead to the identification of druglike candidates with favorable safety profiles that can successfully test hypotheses in the clinic.</p>
Erythropoietin Stimulates Endothelial Progenitor Cells to Induce Endothelialization in an Aneurysm Neck After Coil Embolization by Modulating Vascular Endothelial Growth Factor
Authors: Liu Peixi , Zhou Yingjie , An Qingzhu , Song Yaying , Chen Xi , Yang Guo-Yuan , Zhu Wei 
Published: June 2016

Abstract

This study explored a new approach to enhance aneurysm (AN) neck endothelialization via erythropoietin (EPO)-induced endothelial progenitor cell (EPC) stimulation. Results suggest that EPO enhanced the endothelialization of a coiled embolization AN neck by stimulating EPCs via vascular endothelial growth factor modulation. Thus, the promotion of endothelialization with EPO provides an additional therapeutic option for preventing the recurrence of ANs. Endovascular coil embolization is an attractive therapy for cerebral ANs, but recurrence is a main problem affecting long-term outcomes. In this study, we explored a new approach to enhance AN neck endothelialization via EPO-induced EPC stimulation. Ninety adult male Sprague-Dawley rats were selected for an in vivo assay, and 60 of them underwent microsurgery to create a coiled embolization AN model. The animals were treated with EPO, and endothelial repair was assessed via flow cytometry, immunofluorescence, electronic microscopy, cytokine detection, and routine blood work. EPO improved the viability, migration, cytokine modulation, and gene expression of bone marrow-derived EPCs and the results showed that EPO increased the number of circulating EPCs and improved endothelialization compared with untreated rats (p &lt; .05). EPO had no significant effect on the routine blood work parameters. In addition, the immunofluorescence analysis showed that the number of KDR+ cells in the AN neck was elevated in the EPO-treated group (p &lt; .05). Further study demonstrated that EPO promoted EPC viability and migration in vitro. The effects of EPO may be attributed to the modulation of vascular endothelial growth factor (VEGF). In particular, EPO enhanced the endothelialization of a coiled embolization AN neck by stimulating EPCs via VEGF modulation. Thus, the promotion of endothelialization with EPO provides an additional therapeutic option for preventing the recurrence of ANs.

Significance
Erythropoietin (EPO) is involved in erythropoiesis and related conditions and is reported to enhance stem-cell mobilization from bone marrow while elevating stem-cell viability and function. In this study, EPO was also found to stimulate endothelial progenitor cells to induce the endothelialization of a coiled embolic aneurysm neck via vascular endothelial growth factor modulation. Endothelialization induction provides an additional therapeutic opportunity during vascular inner layer repair and remodeling. The results provide important information on the unique role EPO plays during vascular repair and remodeling.