bluuebunny/crossref_metadata_2025_split huggingface dataset:
A CH4‐Driven Ion Cloud‐Stretched Approach Enables ICP‐qMS for Multiplex Single‐Cell Analysis
Authors: Lv Zhengxian , Yan Xinli , Liu Zhen , Chen Shi , Yan Xiaowen , Yang Limin , Wang Qiuquan 
Published: October 2024

AbstractIn the last 40 years, inductively coupled plasma quadrupole (q) mass spectrometry (ICP‐qMS) has been recognized as one of the best tools for the quantification of multiple elements/isotopes and even the biomolecules they labeled in a homogeneous solution sample. However, it meets a tough challenge when acquiring multi‐m/z signals from an intact single‐cell dispersed in a cell suspension, since the single‐cell ion cloud generated in ICP presents an intermittently transient event with a duration time of hundreds of microseconds while the dwell time plus settling time of the q is at the similar time scale when peak‐hopping between different m/z. Herein, we report CH4 is able to stretch the single‐cell ion cloud duration time to more than 7,000 μs in collision‐reaction‐cell (CRC), allowing multi‐m/z signals acquisition by ICP‐qMS. Quantification of single‐cell's multiple phenotype protein markers can thus be achieved on ICP‐(CH4‐CRC)‐qMS, not only revealing the heterogeneity between the single cells but also enabling an unambiguous cell‐classification of their subtypes. CH4‐driven ion cloud‐stretched approach breaks through the long‐standing bottleneck limited single‐cell multiplex analysis on ICP‐qMS, paving a path for more important applications of ICP‐qMS in the fields related to single‐cell analysis.
Buckybowl‐Based Fullerene Receptors
Authors: Song Wenru , Shao Xiangfeng 
Published: October 2024

AbstractBuckybowls, bowl‐shaped polyaromatic hydrocarbons, have received intensive interest owing to their multifaceted potentials in supramolecular chemistry and materials science. Buckybowls possess unique chemical and physical properties associated with their concave and convex faces. In view of the shape complementarity, which is one of the key factors for host‐guest assembly, buckybowls are ideal receptors for fullerenes. In fact, the host‐guest assembly between buckybowls and fullerenes is one of the most active topics in buckybowls chemistry, and the resulting supramolecular materials show promising applications in optoelectronics, biomaterials, and so forth. In this tutorial review, we present an overview for the progress on fullerene receptors based on buckybowls over the last decade.
Heterometallic [2]Catenane‐Crosslinked Supramolecular Networks with Improved Antibacterial Activity
Authors: Feng Qian , Ding Rui , Zhang Mingming 
Published: October 2024

AbstractThe construction of supramolecular networks with novel crosslinks is of great significance in expanding their chemical structures and exploring their advanced functions. Herein, we prepare a type of [2]catenane‐cored supramolecular networks based on the crosslinking of polyethylene glycol (PEG) using a heterometallic [2]catenane unit. By adjusting the molecular weight of PEG, the solubility of the networks can be tuned and gels are formed using low molecular weight PEG. The introduction of heterometallic [2]catenane offers the networks good antibacterial properties owing to the synergistic antimicrobial activity of Pt(II) and Cu(I) ions in the [2]catenane. This study provides a simple and efficient strategy for constructing supramolecular networks with topological crosslinks as antibacterial materials, which will promote the structural design and biological applications of supramolecular networks.
When do challenge‐hindrance stressors differentially effect employees' ability to meet work deadlines?
Authors: Azeem Muhammad Umer , Mehmood Iqbal , Haq Inam Ul , Nasho Ah‐Pine Elda 
Published: October 2024

AbstractThis study adds to the extant research by investigating the differential effects of challenge‐hindrance stressors on employees' ability to meet work‐related deadlines. We also examine the mediating role of emotional exhaustion and moderating role of core self‐evaluation (CSE) in this process. Using multi‐source, time‐lagged data (N = 203) collected from employee‐supervisor dyads, this study pinpoints an important reason why employees experience of challenge and hindrance stressor invoke differential effects on their ability to meet work‐related deadlines is that they feel emotionally exhaustion when faced with stressful work demands. However, employees with high CSE can control themselves in these uncertain situations such that the indirect effects of challenge‐hindrance stressors on timely completion of work tasks, via exhaustion, are less salient for them. The study implications suggest that HR managers and decision makers need to openly communicate the risks and challenges associated with the work demands so that employees can appraise these tasks as either challenging or hindrance. Moreover, involving employees with high levels of CSE would further increase the chances that employees will complete their work tasks on time.
A 170‐ to 260‐GHz Full‐Band Frequency Doubler Realized by Impedance Compression Matching Technique
Authors: Wu Chengkai , Zhang Yong , Wang Li , Yan Bo , Xu Ruimin 
Published: October 2024

ABSTRACTIn this paper, the bandwidth limitations of frequency multipliers are analyzed theoretically in terms of maximum power transmission. The analysis shows that due to conjugate with the impedance of the diode itself, the optimum embedded impedance of the diode possesses a counterclockwise impedance trajectory versus frequency on the Smith chart, whereas the matching circuit exhibits a clockwise impedance trajectory versus frequency on the Smith chart. Under this constraint, an impedance compression matching technique (ICMT) is proposed to realize broadband design for terahertz frequency multipliers. Based on the proposed design method, a 170‐ to 260‐GHz full‐band frequency doubler was designed, fabricated, and measured. The measured results show that the doubler achieves an output power of 4–7.5 mW in the entire frequency band under 140‐mW input power, corresponding to a conversion loss of 12.5–15.4 dB.
A High Gain Antipodal Vivaldi Antenna Enabled by a High Dielectric Superstrate for Wideband Applications
Authors: Reddy Mekala Harinath , Sheela D. , Premalatha J. , Jayasudha F. V. 
Published: October 2024

ABSTRACTA novel superstrate‐based Vivaldi antenna design characterized by high‐gain and wideband performance is presented. The proposed design configuration features a Vivaldi antenna positioned between high dielectric superstrate (Rogers 6010, εr = 10.2) with copper etched off on both sides and an FR4 substrate that has copper etched on one side only. The introduction of a high permittivity dielectric material above and a reflector below the Vivaldi antenna enables favorable resonance conditions for achieving high‐gain operation. The measured antenna exhibits a peak gain of 17 dBi at 10 GHz, covering an operating frequency range of 6–20 GHz. It also features a narrow half‐power beamwidth and low side lobe level radiation patterns. Unlike existing studies, which rely on metamaterials, electromagnetic bandgap structures, and frequency selective surfaces for gain enhancement, our design employs high‐dielectric constant superstrates. This approach increased the antenna's peak gain by 10 dB. Also, the proposed configuration act as a radome protecting the antenna from Environment.
Effects of atrial fibrillation ablation on arrhythmia burden and ventricular function in end‐stage heart failure: Lessons from CASTLE‐HTx
Authors: Sciacca Vanessa , Sohns Christian , Crijns Harry J.G.M. , Marrouche Nassir F. , Schramm Rene , Moersdorf Maximilian , Fink Thomas , Bergau Leonard , Hindricks Gerhard , Dagres Nikolaos , Sossalla Samuel , Costard‐Jaeckle Angelika , Fox Henrik , El Hamriti Mustapha , Konietschke Frank , Rudolph Volker , Gummert Jan , Tijssen Jan G.P. , Sommer Philipp ,   for the CASTLE HTx Investigators
Published: October 2024

AbstractAimsThe CASTLE‐HTx trial showed the benefit of atrial fibrillation (AF) ablation compared to medical therapy in decreasing mortality, need for left ventricular assist device implantation or heart transplantation (HTx) in patients with end‐stage heart failure (HF). Herein we describe the effects of catheter ablation on AF burden, arrhythmia recurrences, and ventricular function in end‐stage HF.Methods and resultsThe CASTLE‐HTx protocol randomized 194 patients in end‐stage HF with AF to catheter ablation and medical therapy or medical therapy alone. AF burden, left ventricular ejection fraction (LVEF), and type of AF were assessed at baseline and at each follow‐up visit. Overall, 97 patients received ablation; 66 patients (68%) underwent pulmonary vein isolation (PVI) and 31 patients (32%) were treated with PVI and additional ablation. Electroanatomic mapping showed the extent of left atrial low voltage (cardiomyopathy) >10% in 31 (31.9%) patients. At 12 months post‐ablation, persistent AF was present in 31/89 patients (34.8%), which was significantly less frequent compared to baseline (p = 0.0001). Median AF burden reduction was 36.3 (interquartile range 13.6–63.3) percentage points at 12 months and LVEF improved from 29.2 ± 6.2% to 39.1 ± 8.3% (p < 0.001) following ablation. AF burden reduction <50% was significantly associated with LVEF improvement ≥5% at 12 months after ablation (p = 0.017).ConclusionAtrial fibrillation ablation in end‐stage HF leads to a substantial decrease in AF burden, a regression from persistent to paroxysmal AF and notably improved LVEF. Favourable ablation outcomes were observed in patients regardless of the presence or absence of signs indicating left atrial cardiomyopathy.
Synthesis, Photophysical Properties and Optical Limiting Behavior of Organometallic Complexes: Influence of Metal Centers and Conjugated Diimine Ligands
Authors: Wu Chenglong , Bao Yongqi , Ren Guihong , Wang Chenyi , Zhu Senqiang , Liu Rui , Zhu Hongjun 
Published: October 2024

AbstractFour organometallic complexes featuring identical conjugated diimine ligands and varying transition metal centers (Rh(III), Ir(III), Ru(II), and Os(II)) were synthesized. A comprehensive investigation of the photophysical properties of these complexes and their corresponding diimine ligands was conducted by UV‐vis absorption, emission, and transient absorption (TA) spectroscopy, as well as optical power limiting (OPL) measurements. The incorporation of fluorene components with alkyl chains enhanced the π‐conjugation of the ligand, prevented intermolecular π‐π stacking, and improved complex solubility. The diimine ligands showed a slight solvation effect in their emission spectra, indicating that the main property of their emissive state was intramolecular charge transfer (CT). According to the valence states of the four complexes, they can be divided into two classes (Rh(III), Ir(III)) and (Ru(II), Os(II)). For TA spectrum, the former group exhibited positive ΔOD values across the 400~800 nm range, while the latter showed large inverted peaks at 420~500 nm due to significant ground‐state absorption in this wavelength range. Additionally, the optical limiting conduct of the complexes observed the order: 1 d>1 a>1 c>1 b. Complex 1 d exhibits powerful reverse saturable absorption (RSA) properties at 532 nm and could probably be used as an wonderful nonlinear absorbing material.
Model reference adaptive hierarchical control framework for shake table tests
Authors: Chen Zhongwei , Yang T. Y. , Xiao Yifei , Pan Xiao , Yang Wanyan 
Published: October 2024

AbstractThe structural response under earthquake excitation can be simulated by shake table tests. However, the performance of the shake table is affected by the Control‐Structure Interaction (CSI) effect. In recent years, nonlinear control algorithms were developed to compensate for the CSI effect. In this study, a model reference adaptive control algorithm, named model reference adaptive hierarchical control (MRAHC) framework, is presented. MRAHC consists of a high (adaptive) and low (loop‐shaping) level controller. The high‐level (adaptive) controller develops the control algorithm on the system level, which directedly considers the inherent nonlinearity of the test specimen and the CSI effect. While the low‐level (loop‐shaping) controller develops the control algorithm to regulate the hydraulic system and make sure it can follow the reference signal generated by the high‐level (adaptive) controller. MRAHC offers many advantages including direct compensation to the structural nonlinearity and the ability to handle the CSI effect. In addition, it allows users to quantify the mass of the test specimens without measurement. To evaluate the performance of the MRAHC method, shake table tests with different upper structure masses were carried out. The performance of the MRAHC was compared with the direct loop‐shaping control method (LC) and the Proportional‐Integral‐Differentiation control method (PID). The results show that the MRAHC can achieve better acceleration tracking compared to the LC and PID control methods. Hence, the MRAHC can be used as an effective nonlinear controller for shake table tests.
Sleep disturbances in anorexia nervosa
Authors: Burger Pia , Bos Rosita W. , Maas Joyce , Simeunovic‐Ostojic Mladena , Gemke Reinoud J. B. J. 
Published: October 2024

AbstractIntroductionSleep is crucial for physical and psychological health, and disturbances are closely linked to psychiatric disorders, making their management essential for improving treatment outcomes and preventing relapse. Although sleep disturbances are implicated in psychopathology of eating disorders, its role in anorexia nervosa (AN) remains unclear. This review aimed to characterise sleep in AN.MethodsA systematic search was conducted in four scientific databases, including papers from inception to 25 May 2024. A machine learning algorithm (ASReview) was utilised to screen titles and abstracts for eligibility. Sleep quantity, architecture, and quality were investigated. Meta‐analyses were conducted to investigate the difference between patients with AN and healthy controls (HC) in total sleep time (TST), wake after sleep onset (WASO), sleep onset latency (SOL), sleep efficiency, Sleep Stage 1, 2, slow wave sleep, rapid eye movement (REM) sleep and REM latency. Certainty of evidence was assessed using the GRADE approach.ResultsOut of 67 potentially eligible papers, 31 were included in this review, with 15 in the meta‐analyses. Statistically significant average mean differences were found for TST (−32.1 min [95% CI: −50.9, −13.4]), WASO (19.0 min [95% CI: −2.4, 40.3]), and sleep efficiency (−4.4% [95% CI: −7.9, −0.9]). Additionally, Sleep stage 1 was significantly increased (2.4% [95%‐CI: 0.05, 4.7]), while REM sleep was reduced (−2.1% [95%‐CI: −4.2, −0.02]). Subgroup analysis showed that TST and WASO did not improve significantly after weight restoration.ConclusionSleep in patients with AN is impaired, with lower TST and sleep efficiency, higher WASO, more time in stage 1 sleep, and less in REM. Weight restoration alone may not improve sleep. While more research is needed, substantial accompanying sleep disturbances in AN justifies addressing these in current treatment practice, also because of the chronic character of AN and importance of sleep for long term (mental) health.
The Impact of Different Manipulations of the Chorda Tympani Nerve on Taste in Endoscopic Ear Surgery
Authors: Li Rujie , Chen Shuainan , Yu Die , Chen Qiyue , Xia Yuxiang , Huang Yideng 
Published: October 2024

ABSTRACTThe chorda tympani nerve (CTN) plays a significant role in taste transmission and salivary secretion. Due to its course in the tympanic cavity and its relation to the ossicular chain, there is a high risk of iatrogenic damage to the CTN during otologic surgeries. This study aimed to assess the impact of different handling methods of the CTN during endoscopic ear surgery on patients' taste perception. A cohort study conducted from 2022 to 2023 in a tertiary hospital involved participants undergoing various types of endoscopic ear surgeries. Based on intraoperative handling of the CTN, participants were divided into three groups: intact, traction (subdivided into mild, moderate and severe traction subgroups) and transection (subdivided into transection without tension, with tension and tearing subgroups). Taste tests were administered from 1 day before surgery to 6 months postoperatively. Endoscopic ear surgery for treating ear pathologies. Taste test scores, other relevant symptoms. Significant differences were observed in the incidence and recovery time of taste dysfunction across groups. The rate of taste abnormalities and recovery time increased with the degree of traction; the severe traction and transection subgroups showed the highest rates of abnormalities and cases of incomplete recovery. In terms of disease type, patients with chronic suppurative otitis media and cholesteatoma showed significant differences in preoperative taste status, abnormality rates and recovery times compared to patients with non‐inflammatory ear diseases. General sensory abnormalities of the tongue were mainly found in moderate‐to‐severe traction subgroups and all transection groups, often accompanying taste reduction or loss. Some patients in the transection group experienced only numbness or both increased taste sensation and numbness. The study underscores the importance of delicate handling of the CTN in endoscopic ear surgery, especially in patients with inflammatory middle ear diseases. It suggests minimising severe traction injuries and considering early and accurate transection to reduce traction injuries when preservation is challenging; any manipulation of the CTN should be avoided in patients with non‐inflammatory conditions. This research provides valuable theoretical support for clinical practice.
Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
Authors: Herrera‐Martínez Aura D. , Prior‐Sánchez Inmaculada , Fernández‐Soto María Luisa , García‐Olivares María , Novo‐Rodríguez Cristina , González‐Pacheco María , Martínez‐Ramirez María José , Carmona‐Llanos Alba , Jiménez‐Sánchez Andrés , Muñoz‐Jiménez Concepción , Torres‐Flores Fátima , Fernández‐Jiménez Rocío , Boughanem Hatim , del Galindo‐Gallardo María Carmen , Luengo‐Pérez Luis Miguel , Molina‐Puerta María Josefa , García‐Almeida José Manuel 
Published: October 2024

AbstractBackgroundMalnutrition and sarcopenia are highly prevalent in patients with head neck cancer (HNC). An accurate early diagnosis is necessary for starting nutritional support, as both are clearly associated with clinical outcomes and mortality. We aimed to evaluate the applicability and accuracy of body composition analysis using electrical bioimpedance vectorial analysis (BIVA) for diagnosing malnutrition and sarcopenia in patients with HNC cancer undergoing systemic treatment with chemotherapy or radiotherapy.MethodsCross‐sectional, observational study that included 509 HNC patients. A comprehensive nutritional evaluation that included BIVA was performed.ResultsThe prevalence of malnutrition was higher in patients that received treatment with chemotherapy (59.2% vs. 40.8%, P < 0.001); increased mortality was observed in malnourished patients (33.3% vs. 20.1%; P < 0.001); ECOG status (1–4) was also worse in malnourished patients (59.2% vs. 22.8% P < 0.001). Body cell mass (BCM) and fat mass were the most significantly associated parameters with malnutrition [OR 0.88 (0.84–0.93) and 0.98 (0.95–1.01), respectively]; BCM and fat free mass index (FFMI) were associated with several aspects including (1) the patient‐generated subjective global assessment [OR 0.93 (0.84–0.98) and 0.86 (0.76–0.97), respectively], (2) the presence of sarcopenia [OR 0.81 (0.76–0.87) and 0.78 (0.66–0.92), respectively]. A BCM index (BCMI) < 7.8 in combination with other parameters including FFMI and BCM accurately predicted patients with malnutrition [accuracy 95% CI: 0.803 (0.763–0.839); kappa index: 0.486; AUC: 0.618 (P < 0.01)]. A BCMI cutoff of 7.6 was enough for identifying males with malnutrition (P < 0.001), while it should be combined with other parameters in females.ConclusionsBody composition parameters determined by BIVA accurately identify patients with HNC and malnutrition. Phase angle, but other parameters including BCMI, FFMI and BCM provide significant information about nutritional status in patients with HNC.
An evaluation by dental clinicians of cutting characteristics and haptic perceptions in 3D‐printed typodont teeth: A pilot study
Authors: Cresswell‐Boyes Alexander J. , Davis Graham R. , Barber Asa H. , Krishnamoorthy Mahentha , Nehete Swati R. 
Published: October 2024

AbstractObjectivesThis study aimed to compare the haptic perception of clinicians to the cutting response of 3D‐printed typodont teeth and commercial typodont teeth and human extracted teeth.MethodsTwenty clinicians were asked to perform a Class I cavity preparation on commercial typodont teeth, 3D‐printed typodont teeth, and human extracted teeth, while the forces were recorded via a three‐axis load cell. The haptic perception of clinicians was also evaluated through a response questionnaire comparing commercial and 3D‐printed typodont teeth.ResultsThe study found that clinicians used similar forces (p = 0.53) to cut both the 3D‐printed typodont teeth (1.37 N) and the human extracted teeth (1.44 N), but more force was needed to cut the commercial typodont teeth (3.71 N). The response questionnaire indicated that clinicians rated the 3D‐printed typodont teeth highly compared to the commercial teeth. The 3D‐printed dentine received favorable feedback from clinicians, and the 3D‐printed enamel was rated higher compared to the commercial equivalents.ConclusionsThe results of the study suggest that 3D‐printed typodont teeth offer a comparable haptic perception to human extracted teeth and can be used as an effective tool for preclinical dental learning. Moreover, the study highlights the advantages of 3D‐printed typodont teeth over commercial typodont teeth in terms of haptic perception.
Eosinophilic pustular folliculitis associated with IgA deficiency
Authors: Flowers L. E. , Subhadarshani S. , Quinter S. , Shaughnessy C. 
Published: October 2024

AbstractEosinophilic pustular folliculitis (EPF) is a noninfectious follicular based inflammatory dermatosis. We present a case of a 57‐year‐old female of Indian ethnicity who developed a pustular eruption, with certain lesions displaying Koebnerization. Given that the morphologic distribution most represented the immunosuppressant EPF subtype, additional testing led to the discovery of concurrent IgA deficiency. This case highlights a particularly unusual presentation of EPF associated with IgA deficiency and Koebner phenomenon.