bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Lung Cancer Risk Prediction Machine Learning Models for Equitable Learning Health System: Retrospective Study
Authors: Chen Anjun , Wu Erman , Huang Ran , Shen Bairong , Han Ruobing , Wen Jian , Zhang Zhiyong , Li Qinghua 
Published: September 2024

Background
A significant proportion of young at-risk patients and nonsmokers are excluded by the current guidelines for lung cancer (LC) screening, resulting in low-screening adoption. The vision of the US National Academy of Medicine to transform health systems into learning health systems (LHS) holds promise for bringing necessary structural changes to health care, thereby addressing the exclusivity and adoption issues of LC screening.

Objective
This study aims to realize the LHS vision by designing an equitable, machine learning (ML)–enabled LHS unit for LC screening. It focuses on developing an inclusive and practical LC risk prediction model, suitable for initializing the ML-enabled LHS (ML-LHS) unit. This model aims to empower primary physicians in a clinical research network, linking central hospitals and rural clinics, to routinely deliver risk-based screening for enhancing LC early detection in broader populations.

Methods
We created a standardized data set of health factors from 1397 patients with LC and 1448 control patients, all aged 30 years and older, including both smokers and nonsmokers, from a hospital’s electronic medical record system. Initially, a data-centric ML approach was used to create inclusive ML models for risk prediction from all available health factors. Subsequently, a quantitative distribution of LC health factors was used in feature engineering to refine the models into a more practical model with fewer variables.

Results
The initial inclusive 250-variable XGBoost model for LC risk prediction achieved performance metrics of 0.86 recall, 0.90 precision, and 0.89 accuracy. Post feature refinement, a practical 29-variable XGBoost model was developed, displaying performance metrics of 0.80 recall, 0.82 precision, and 0.82 accuracy. This model met the criteria for initializing the ML-LHS unit for risk-based, inclusive LC screening within clinical research networks.

Conclusions
This study designed an innovative ML-LHS unit for a clinical research network, aiming to sustainably provide inclusive LC screening to all at-risk populations. It developed an inclusive and practical XGBoost model from hospital electronic medical record data, capable of initializing such an ML-LHS unit for community and rural clinics. The anticipated deployment of this ML-LHS unit is expected to significantly improve LC-screening rates and early detection among broader populations, including those typically overlooked by existing screening guidelines.
Spatial analysis of tuberculosis cases diffusion based on population density in Bekasi Regency in 2017-2021
Authors: Inggarputri Yuanita Rizky , Trihandini Indang , Novitasari Prihatini Dini , Makful Martya Rahmaniati 
Published: September 2024

Purpose: This research aims to examine the spatial relationship between tuberculosis cases and population density and their spatial diffusion patterns in Bekasi Regency in 2017-2021.
Methods: Research using an ecological study design using spatial analysis to estimate and analyze the distribution of tuberculosis prevalence related to population density in 23 sub-districts in Bekasi Regency, compare data from 2017 to 2021 and evaluate the spatial correlation. The data is taken from secondary data from the Bekasi District Health Office for 2017-2021.
Results: This study shows a spatial autocorrelation between tuberculosis cases and population density from 2017 to 2021 (I>E; p-value <0,05). There is spatial diffusion of cases characterized by expanding clusters with high tuberculosis cases. High-high cluster in 2017, there was one sub-district. In 2018 there was also one sub-district. In 2019 there were two sub-districts. In 2020, there were three sub-districts. And in 2021, there were five districts.
Conclusion: This research shows a positive spatial autocorrelation in the incidence, which is influenced by population density in Bekasi Regency from year to year (2017-2021) with a clustering pattern.
Pengaruh Daya Tarik Wisata dan Seni Fotografi dalam Meningkatkan Keputusan Berwisata
Authors: Aling Florenza Angeli Nazaretha , Semara I Made Trisna , Amir Firlie Lanovia 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh daya tarik wisata dan seni fotografi secara parsial dan simultan terhadap keputusan berwisata di KDTWK Kintamani. Pengambilan sampel terhadap responden dalam penelitian ini yaitu sebanyak 100 responden. Teknik analisis data yang digunakan dalam penelitian ini adalah Uji Analisis Regresi Linear Berganda. Dari hasil penelitian dapat dilihat bahwa daya tarik wisata scecara simultan berpengaruh positif signifikan terhadap keputusan berwisata, kemudian seni fotografi juga berpengaruh positif signifikan terhadap keputusaan berwisata oleh wisatawan Besarnya pengaruh pemasaran daya tarik wisata dan seni fotografi terhadap keputusan berwisata adalah 59,2%. Kesimpulannya semakin baik daya tarik wisata dan aktivitas seni fotografi yang terdapat di KDTWK Kintamani, maka akan semakin meningkatkan keputusan wisatawan dalam berwisata di KDTWK Kintamani.

This research aims to determine the partial and simultaneous influence of tourist attractions and the art of photography on travel decisions at KDTWK Kintamani. The sampling of respondents in this research was 100 respondents. The data analysis technique used in this research is the Multiple Linear Regression Analysis Test. From the research results, it can be seen that tourist attractions simultaneously have a significant positive effect on travel decisions, then the art of photography also has a significant positive effect on tourists' travel decisions. The magnitude of the influence of tourist attraction marketing and photography art on travel decisions is 59.2%. In conclusion, the better the tourist attraction and photography art activities found at KDTWK Kintamani, the more it will improve tourists' decisions about traveling to KDTWK Kintamani.
The Relationship between Learning Readiness and Learning Outcomes of Package C Students at PKBM Titian Amanah Kayu Tanam
Authors: Elvira Salman Iza , Syur'aini Syur'aini 
Published: September 2024

The purpose of study is to ascertain how adult student learning outcomes in Indonesian language classes at PKBM Titian Amanah relate to their readiness for learning. Attention, drive, and the growth of personal preparedness are all components of learning readiness. This study employed a correlational research design and a quantitative methodology. The questionnaire measures the level of learning readiness in terms of attention, motivation and development of individual readiness. Findings of this research indicate the learning readiness of adult students Package C program at PKBM Titian Amanah is in the low category, especially in terms of attention and motivation. This is evident from respondents' propensity to select "disagree" option in the questionnaire. However, research also finds a significant relationship between learning readiness and learning outcomes. Students with a higher level of readiness tend to achieve better learning outcomes. Based on the results of this research, there are several recommendations that can be given. First, PKBM Titian Amanah must provide better facilities to increase adult students' learning readiness. Second, tutors must be more creative in using learning media to increase learning motivation. Additionally, future research could explore the relationship between learning readiness and learning outcomes.Keywords: Learning Readiness, Learning Outcomes
Formulation of Emulsion with a Combination of Microalgae Chlorella sp. with Gourami Fish Oil (Osphronemus gouramy L.)
Authors: Utari Widi Gustita , Alfayzah Faradillah , Junaida Alfini , Maharani Della Shinta , Pratama Muhammad Imran Ade , Pratiwi Eskarani Tri 
Published: September 2024

Introduction:. Chlorella sp. is a type of microalgae that has high nutritional value and is often cultivated for various purposes such as medicines or supplements. One of the efforts that can be made to optimize the benefits of Chlorella sp. microalgae with a combination of gourami fish oil formulated in an emulsion reparation. Aims: determine the best formula and physical stability of Chlorella sp. microalgae emulsion with gourami fish oil. Method: making emulsion with varying concentrations of Chlorella sp. microalgae with gourami fish oil (F1= 1:1, F2= 2:1, and F3=3:1). The physical preparation stability test will be carried out such as organoleptic test, homogeneity, pH, viscosity, emulsion type and stability. Results: all three formulas met the requirements for physical evaluation of emulsion preparations, only in the stability test there was separation at F3 (3:1). The type of emulsion produced is oil in water (O/W). Conclusion: the best formula according to the test results is F1 & F2.
Terapi Bekam dan Madu Pada Pasien Post Stroke Iskemik (Studi Literatur)
Authors: Suryaningsi  , Wahyuddin Munifah , Maddeppungeng Nurul Muhlisah , Naurah Nazifah Haery  
Published: September 2024

Terapi bekam dan madu adalah salah satu terapi non farmakologi yang merupakan metode pengobatan Rasulullah Muhammad saw (thibbun nabawi) yang bermanfaat terhadap pengobatan pasien post stroke iskemik. Penelitian ini bertujuan untuk mengetahui manfaat penggunaan terapi bekam dan madu pada pasien post stroke iskemik. Jenis penelitian ini adalah studi literatur, menggunakan pustaka primer berupa jurnal nasional dan internasional 5 tahun terakhir sebanyak 30 jurnal. Metode yang digunakan adalah PICO(T). Hasil penelitian menunjukkan bahwa: Cara/metode terapi bekam untuk pasien post stroke iskemik adalah metode bekam basah dengan menggunakan alat jarum bekam dengan cara ditusuk pada titik-titik terapi di bagian kepala, pundak, leher, atau punggung untuk mengeluarkan darah kotor akibat penyempitan pada pembuluh darah; Terapi bekam bermanfaat menimbulkan respon emosional yang dapat mempengaruhi fungsi kognitif dan motorik pasien post stroke iskemik, dapat meningkatkan kualitas hidup, dan melancarkan aliran darah daerah saraf ataupun jaringan yang tersumbat; Terapi madu memiliki manfaat dalam aspek pengobatan, terutama penyakit pada sistem saraf yang dapat memperbaiki kandungan oksidatif sistem saraf pusat dan dapat dianggap sebagai agen terapi alami untuk berbagai tujuan terapi pengobatan.
Studi Literatur Perbandingan Metode Uji Antioksidan pada Tanaman Kopi Robusta (Coffea robusta)
Authors: Wahyuddin Munifah , Faridha Yenny Nonci  , Nur Azizah Syahrana  , Nursasmita  
Published: September 2024

Abstrak
Antioksidan merupakan suatu senyawa yang dapat mencegah dan memperlambat kerusakan yang disebabkan oleh radikal bebas melalui penghambatan mekanisme oksidatif. Banyaknya metode uji aktivitas antioksidan dapat memberikan hasil uji yang beragam. Hal tersebut diakibatkan oleh adanya pengaruh dari struktur kimiawi antioksidan, sumber radikal bebas, dan sifat fisiko-kimia dari sampel. Penelitian ini bertujuan untuk mengetahui perbandingan metode antioksidan pada tanaman kopi robusta (Coffea robusta) berdasarkan kajian literatur. Dalam penelitian ini menggunakna metode kajian literatur, database dari Google Scholar, Science Direct dan Tylor & Francis. Hasil yang diperoleh adalah metode ABTS menunjukkan hasil aktivitas total antioksidan paling tinggi di mana nilai aktivitas antioksidannnya adalah 32.42±1.66 g trolox/100 g; 83,63%; 10.90±0.63 mg TE/g DW; 22.59±1.11 μ/ml; diikuti dengan metode Folin-Ciocalteu di mana nilai total aktivitas antioksidannya adalah 385±1 g GAE/ kg dan 1043 mg GAE/L dengan kandungan senyawa dalam tanaman kopi robusta (Coffea robusta) meliputi kafein, flavonoid, fenolik, dan asam klorogenat yang merupakan sumber antioksidan yang baik.

Kata kunci: Coffea robusta, Antioksidan, Metode uji antioksidan
Prevalence of Commorbid Lung Tuberculosis Diabetes Mellitus in Sultan Syarif Mohamad Alkadrie Pontianak Hospital in 2019
Authors: Ardhi Terence , Fitriangga Agus , Putri Eka Ardiani 
Published: September 2024

<p>Pulmonary tuberculosis (TB) can be made worse by a history of Diabetes Mellitus (DM), which can increase the risk of failure treatment, relapse, and longer duration of treatment. <span data-preserver-spaces="true"> <span data-preserver-spaces="true"><strong>Objective</strong></span><span data-preserver-spaces="true">: To find out the prevalence of Pulmonary TB comorbid DM at Sultan Syarif Mohamad Alkadrie General Hospital Pontianak. <strong><span data-preserver-spaces="true">Methods</span></strong><span data-preserver-spaces="true">: This research was a descriptive observational study with a cross-sectional design. The population in this study were all patients diagnosed with pulmonary tuberculosis at the Sultan Syarif Mohamad Alkadrie Hospital Pontianak from 1 January to </span><span data-preserver-spaces="true">December 31st, 2019</span><span data-preserver-spaces="true">. </span><span data-preserver-spaces="true">Data </span><span data-preserver-spaces="true">collection </span><span data-preserver-spaces="true">was carried out</span><span data-preserver-spaces="true"> by taking</span><span data-preserver-spaces="true"> secondary data on patients diagnosed with pulmonary TB with a history of DM in outpatient and inpatient installations at Sultan Syarif Mohamad Alkadrie General Hospital Pontianak.</span><strong><span data-preserver-spaces="true">Results</span></strong><span data-preserver-spaces="true">: There were 1311 pulmonary TB patients in Sultan Syarif Mohamad Alkadrie General Hospital Pontianak in 2019; pulmonary TB patients with a history of DM as many as 98 patients obtained from 73 outpatient installations and inpatients hospitalized as many as 25 patients. The results showed that the prevalence of pulmonary TB comorbid DM was 7.47%. </span><strong><span data-preserver-spaces="true">Conclusion</span></strong><span data-preserver-spaces="true">: The prevalence of pulmonary TB comorbid DM in RSUD Sultan Syarif Mohamad Alkadrie Pontianak is relatively low.</span></span></span></p><p><span data-preserver-spaces="true"><strong>Keywords</strong></span><span data-preserver-spaces="true">: ages, diabetes mellitus, pulmonary TB</span></p>
Adding Manual Therapy to an Exercise Program Improves Long-Term Patient Outcomes Over Exercise Alone in Patients With Subacromial Shoulder Pain: A Randomized Clinical Trial
Authors: Michener Lori A. , McClure Philip W. , Tate Angela R. , Bailey Lane B. , Seitz Amee L. , Straub Rachel K. , Thigpen Charles A. 
Published: September 2024

OBJECTIVE: Guidelines include manual therapy and exercise for subacromial shoulder pain, but there is low certainty for these recommendations. Here, we evaluated if adding manual therapy to a resistance exercise program improved patient outcomes. DESIGN: Randomized parallel controlled clinical trial. METHODS: Individuals with subacromial pain syndrome (N = 93) were randomized to exercise (EX; n = 41) or exercise plus spine and shoulder manual therapy (EX+MT; n = 52). Primary outcome of Disabilities of the Arm, Shoulder and Hand (DASH) and secondary outcome of satisfaction with shoulder use (Satisfaction-shoulder) at baseline, 2, 4, 6, 26, and 52 weeks were compared between groups. Secondary outcomes of additional health care use were compared at 26 and 52 weeks and GROC success (≥“moderately better”) at 2, 4, 6, 26, and 52 week prevalence were compared between groups. RESULTS: The EX+MT group had better DASH scores at 26 weeks (mean difference = 4.9 [95% CI: 9.8, 0.1], P = 0.047) and 52 weeks (mean difference = 6.7 [95% CI: 11.4, 2.1], P = 0.005) compared to the EX group. The EX+MT group had better Satisfaction-shoulder scores at 26 weeks (mean difference = 0.8 [95% CI: 0.2, 1.5], P = 0.012) and 52 weeks (mean difference = 1.2 [95% CI: 0.5, 1.8], P<0.001) compared to the EX group. Higher GROC success was found at 26 and 52 weeks in EX+MT ( P<0.05). There were no differences for additional health care use ( P>0.171). CONCLUSION: Manual therapy added to a resistance exercise program improved long-term shoulder disability, satisfaction, and perceived benefit in patients with subacromial pain. Both groups had improved outcomes over time, with greater effects for the EX+MT group at 26 and 52 weeks. JOSPT Open 2024;2(1):29-48. Epub 11 December 2023. doi:10.2519/josptopen.2023.1134
Treating Early Hip, Knee, and Ankle Joint Osteoarthritis in Professional and Elite Athletes – What Works? A Scoping Review
Authors: Pillay Lervasen , de Beer Sabine , Janse van Rensburg Dina Christa , Kerkhoffs Gino M. , Gouttebarge Vincent 
Published: September 2024

OBJECTIVE: To summarize the existing evidence regarding the effectiveness of interventions to manage early hip, knee, and ankle osteoarthritis in active elite or professional athletes. DESIGN: Scoping review. DATA SOURCES: Medline (PubMed), SPORTDiscus, ScienceDirect, and Epistomonikos. ELIGIBILITY CRITERIA: Peer-reviewed publications from 2012 to 2023 in English, Dutch, or French that included active elite/professional athletes with osteoarthritis and/or cartilage injury to the hip, knee, and/or ankle joints and outcomes measured using validated tools. OUTCOME MEASURES: Patient-reported outcome scores relating to function and return to sports. RESULTS: Twenty-seven studies were included from 414 identified: two on exercise and rehabilitation, four on joint injections, and twenty-one on surgery. For the “Exercise and rehabilitation” category, the evidence was insufficient to recommend conventional training or whole-body vibration training for patellofemoral pain. For the “Joint injections” category, hip and knee hyaluronic acid injections appear safe and effective for improving symptoms, delaying hip joint degeneration and return to sport in 50% to 100% of athletes. Platelet-rich plasma was not as effective as hyaluronic acid in the knee joint. Strong evidence supported corticosteroids and/or local anaesthetic in relieving knee joint symptoms allowing short-term return to sport but hastening the development of knee osteoarthritis. For the “Surgery” category, there was insufficient evidence to support surgical interventions as effective interventions in the hip, knee, and ankle joints of athletic populations for managing early osteoarthritis and precursor pathology. CONCLUSION: There was insufficient evidence to provide clear recommendations about which interventions are best for managing lower limb osteoarthritis in the elite or professional athlete. JOSPT Open 2024;2(2):71-81. Epub 24 January 2024. doi:10.2519/josptopen.2024.0806
Sway detection in hypertension as a novel tool to anticipate risk and morbidity due to postural instability
Authors: Taranikanti Madhuri , Mudunuru Aswin Kumar , Gaur Archana , John Nitin Ashok , Taranikanti Sai Shriya , Umesh Madhusudhan , Ganji Vidya , Medala Kalpana , Varatharajan Sakthivadivel 
Published: September 2024

Objectives:
Hypertension contributes substantially to poor physical function and autonomic imbalance. It may cause instability in posture that limits daily activities and can lead to devastating falls. Centre of pressure (CoP) is a commonly used index of postural stability while standing and is a measure of the activity of the motor system, which may be altered in hypertension. It is also observed that the fall incidence is higher in women than men, which may be due to postural instability. The pilot study was conducted to see whether the presence of essential hypertension further contributes to postural instability in women and compared with age-matched normotensive controls.

Materials and Methods:
Sixteen hypertensive women on regular treatment for hypertension and 16 age-matched normotensive women with a mean age of 51.9 ± 9.1 years were included in the study. The WII balance board was used to measure the CoP and displacement to sway. PowerLab 8/35 (AD instruments) with LabChart software was used to measure the parameters.

Results:
Displacement of CoP in the mediolateral direction was studied in the trials. The CoP was measured in eyes closed and eyes open conditions and was displaced in both groups, with significant displacement in hypertensive women. With voluntary sway to their right and left sides, hypertensive women have shown significantly less sway displacement compared to normotensive women. In hypertensives, during right sway, the error of correction was 13%. During left sway, overcorrection was high in both hypertensive and normotensive.

Conclusion:
Postural instability is observed in hypertension, and posturography can be used as a routine screening tool to predict postural instability in hypertensives. Balance training exercise biofeedback protocols and the use of sensory augmentation devices may prove to be useful in improving postural stability.
МАЛЫЙ БИЗНЕС: ИСТОРИЯ, ПРОБЛЕМЫ И ИХ РЕШЕНИЯ
Authors: Архипова И.И. 
Published: September 2024

Целью исследования является анализ сложившейся ситуации в малом бизнесе. Автор рассматривает этапы развития малого бизнеса в России. В статье указывается, что в настоящий период времени происходит снижение доли малого бизнеса в экономике за счёт маленькой покупательной способности населения, а также за счет ценовой конкуренции с крупными предприятиями. В статье выделяются положительные и отрицательные стороны для предпринимателя при организации малого бизнеса. Автор указывает в статье, что малый бизнес нужен государству, поскольку именно он поддерживает занятость, а это в свою очередь влияет на экономическое развитие государства. В заключении автор выделяет проблемы, с которыми сталкивается малый бизнес, а также предлагает пути их решения.
НАЦИОНАЛЬНЫЕ ПРОЕКТЫ РОССИИ ДЛЯ ДЕТЕЙ
Authors: Халтурина О.А. 
Published: September 2024

Данная обзорная статья оценивает реализацию национальных проектов России для детей. Каждый из национальных проектов, реализация которых предусмотрена указом Президента Российской Федерации от 7 мая 2018 г. № 204 «О национальных целях и стратегических задачах развития Российской Федерации на период до 2024 года», содержит федеральные проекты. Реализация большинства из них осуществляется в интересах всех граждан страны. Некоторые имеют узкую направленность, например, для определенного возраста, для детей, для пенсионеров. Начиная с 2020 года Россия находится в режиме жесткого ограничения деятельности, обусловленного пандемией COVID- 19 и антироссийскими санкциями. Автор оценивает реализацию федеральных проектов России для детей. Анализ официальной статистики показывает, что, по всем федеральных проектам наблюдается недофинансирование, начиная с момента их появления - с 2019 года. Наихудшие результаты финансирования из федерального бюджета отмечаются в 2021 году, сумма финансирования уменьшилась практически в два раза. Правительством России предпринимаются меры как финансового, так и организационного характера в рамках максимальной реализации всех национальных, и федеральных проектов в том числе, что обусловлено социальными целями каждого из проектов