bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic Interaction- and Phospho-Proteomics Reveal Lck as a Major Signaling Hub of CD147 in T Cells
Authors: Supper Verena , Hartl Ingrid , Boulègue Cyril , Ohradanova-Repic Anna , Stockinger Hannes 
Published: February 2017

Abstract
Numerous publications have addressed CD147 as a tumor marker and regulator of cytoskeleton, cell growth, stress response, or immune cell function; however, the molecular functionality of CD147 remains incompletely understood. Using affinity purification, mass spectrometry, and phosphopeptide enrichment of isotope-labeled peptides, we examined the dynamic of the CD147 microenvironment and the CD147-dependent phosphoproteome in the Jurkat T cell line upon treatment with T cell stimulating agents. We identified novel dynamic interaction partners of CD147 such as CD45, CD47, GNAI2, Lck, RAP1B, and VAT1 and, furthermore, found 76 CD147-dependent phosphorylation sites on 57 proteins. Using the STRING protein network database, a network between the CD147 microenvironment and the CD147-dependent phosphoproteins was generated and led to the identification of key signaling hubs around the G proteins RAP1B and GNB1, the kinases PKCβ, PAK2, Lck, and CDK1, and the chaperone HSPA5. Gene ontology biological process term analysis revealed that wound healing–, cytoskeleton-, immune system–, stress response–, phosphorylation- and protein modification–, defense response to virus–, and TNF production–associated terms are enriched within the microenvironment and the phosphoproteins of CD147. With the generated signaling network and gene ontology biological process term grouping, we identify potential signaling routes of CD147 affecting T cell growth and function.
Gliadin-Specific CD8+ T Cell Responses Restricted by HLA Class I A*0101 and B*0801 Molecules in Celiac Disease Patients
Authors: Picascia Stefania , Sidney John , Camarca Alessandra , Mazzarella Giuseppe , Giardullo Nicola , Greco Luigi , Auricchio Renata , Auricchio Salvatore , Troncone Riccardo , Sette Alessandro , Gianfrani Carmen 
Published: February 2017

Abstract
Initial studies associated the HLA class I A*01 and B*08 alleles with celiac disease (CD) susceptibility. Subsequent analyses showed a primary association with HLA class II alleles encoding for the HLA DQ2.5 molecule. Because of the strong linkage disequilibrium of A*01 and B*08 alleles with the DR3-DQ2.5 haplotype and a recent genome-wide association study indicating that B*08 and B*39 are predisposing genes, the etiologic role of HLA class I in CD pathogenesis needs to be addressed. We screened gliadin proteins (2α-, 2ω-, and 2γ-gliadin) using bioinformatic algorithms for the presence of peptides predicted to bind A*0101 and B*0801 molecules. The top 1% scoring 9- and 10-mer peptides (N = 97, total) were synthesized and tested in binding assays using purified A*0101 and B*0801 molecules. Twenty of ninety-seven peptides bound B*0801 and only 3 of 97 bound A*0101 with high affinity (IC50 &lt; 500 nM). These 23 gliadin peptides were next assayed by IFN-γ ELISPOT for recognition in peripheral blood cells of CD patients and healthy controls carrying the A*0101 and/or B*0801 genes and in A*0101/B*0801− CD patients. Ten of the twenty-three peptides assayed recalled IFN-γ responses mediated by CD8+ T cells in A*0101/B*0801+ patients with CD. Two peptides were restricted by A*0101, and eight were restricted by B*0801. Of note, 50% (5/10) of CD8+ T cell epitopes mapped within the γ-gliadins. Our results highlight the value of predicted binding to HLA molecules for identifying gliadin epitopes and demonstrate that HLA class I molecules restrict the anti-gluten T cell response in CD patients.
Diet and Women Fertility: A Descriptive Cross-sectional Study
Authors: Alabd Ruaa E , Abdulmajeed Kefah H , Oufi Hayder G 
Published: February 2017

ABSTRACT

Aims
This work was designed to assess the role of diet and dietary habits on women fertility.

Materials and methods
This study was carried out in seven different centers and hospitals in Baghdad in the period between January and September 2014. Participants were 400 adult women selected conveniently; their age ranged from 17 to 47 years and they were divided into two groups. Group I included 300 fertile women and group II included 100 infertile women. A specific questionnaire had been designed and used for data collection

Results
It was found that there was a significant difference in weight and body mass index (BMI) between the infertile group and control group. The mean of weights was 73.07 vs 69.06 kg for infertile and the control group respectively, while the mean BMI was 28.83 vs 26.70 for the infertile group and the control group respectively. Moreover, the infertile women consumed more of carbonated beverages, tea, chicken, and fish than the control group, while they consumed less milk and red meat than the control group. Also, the infertile group consumed less corn oil and olive oil than the control group (5 and 0% vs 21 and 2%) respectively, while they used to consume more solid fat and combined fat than the control group (2 and 6% vs 0 and 2.7%) respectively.

Conclusion
Although treatment options for infertility are available, their high cost and frequency of adverse events have motivated the identification of dietary factors related to infertility. The current study identified diet as one of the modifiable risk factors that potentially impacts fertility in the selected groups; hence, it is important to focus more on the role of diet in women fertility and increase the awareness of women to it, along with suggesting more educational programs at the primary health care level.

How to cite this article
Alabd RE, Abdulmajeed KH, Oufi HG. Diet and Women Fertility: A Descriptive Cross-sectional Study. Int J Infertil Fetal Med 2016;7(3):82-88.
Prevalence and Pattern of Mandibular Third Molar Impaction in Eritrean Population: A Retrospective Study
Authors: Kumar V Raj , Yadav Priya , Kahsu Efrem , Girkar Farhana , Chakraborty Rajnish 
Published: February 2017

ABSTRACTIntroductionThe most commonly impacted tooth in the oral cavity is the mandibular third molar. Various etiologic factors have been suggested for impacted mandibular third molars. The pattern and prevalence of impacted mandibular third molars vary with different population and region. This study throws light on the prevalence and pattern of impacted mandibular third molars in Eritrea, East Africa. This is the first reported study regarding the same from Eritrea.AimTo assess the prevalence and pattern of impacted mandibular third molars in the population of Eritrea, East Africa by conducting a retrospective study from January 2009 to January 2014.Materials and methodsThis study was conducted in the Department of Oral and Maxillofacial Surgery, Orotta School of Medicine and Dental Medicine and the Orotta Referral Medical and Surgical Hospital, Asmara, Eritrea. A total of 1,813 clinical and radiographic records [orthopantomograms] were assessed and 276 cases were selected for the study as per the inclusion criteria. They were evaluated for the frequency among the various age groups, gender and region along with the sides affected, angulation and level of impaction. The presence of systemic conditions and associated pathologies was also assessed according to the type of impaction.ResultsThe average age of these patients in the study was found to be 30 years, with the 20 to 30 years age group being the most affected (67.4%). Females (53.3%) were affected more than the males (46.7%). People from the Asmara region showed significantly more prevalence (79.7%) than the adjoining areas (20.3%). Mesioangular impaction was the most common angulation with a definite relationship to the age groups (p = 0.032). The level of impaction had no significant relationship to the age groups, gender, or region, although class I position A was found to be the most common type. Mesioangular class I position A impaction showed an apparent relationship with underlying systemic conditions, but it was statistically insignificant. Mesioangular impaction was found to be associated with the most number of pathologies (p = 0.001).ConclusionThe prevalence of mandibular impaction was less in Eritrea (15.2%) compared with other populations. This study provides useful baseline data for the prevalence and pattern of mandibular impaction in the Eritrean population.Clinical significanceThis study throws light on the pattern, type, and frequency of mandibular impacted teeth as per age, sex, and region among the population of Eritrea.How to cite this articleKumar VR, Yadav P, Kahsu E, Girkar F, Chakraborty R. Prevalence and Pattern of Mandibular Third Molar Impaction in Eritrean Population: A Retrospective Study. J Contemp Dent Pract 2017;18(2):100-106.
Rare Case of Intrahepatic Pancreatic Pseudocyst misdiagnosed as Hepatic Abscess
Authors: Tyagi Sagar , Hans Parveen , Singh Robin 
Published: February 2017

ABSTRACT

Introduction
Pseudocyst formation is a well known complication of pancreatitis. Intrahepatic pancreatic pseudocyst is very rare event and only about 30 cases have been reported in literature.
We report here a case of 32-year-old male who was previously diagnosed as a case of hepatic abscess. He was referred to our department for ultrasonography (USG) and contrast enhanced computed tomography (CECT) abdomen with complaint of recurrent pain in upper abdomen. On the basis of findings of CECT Abdomen, diagnosis of large intrahepatic pancreatic pseudocyst in left lobe of liver is made.

Conclusion
Intrahepatic pseudocyst should be considered a differential diagnosis of cystic hepatic lesions in the patients with chronic or recent episode of acute pancreatitis. Computed tomography and high level of amylase in the collection plays an important role for diagnosing this complication.

How to cite this article
Hans P, Tyagi S, Sinha P, Kumar L, Gupta D, Singh R. Rare Case of Intrahepatic Pancreatic Pseudocyst misdiagnosed as Hepatic Abscess. Int J Adv Integ Med Sci 2016;1(4):191-193.
Spontaneous Cholecystocutaneous Fistula
Authors: Abbey Rajesh 
Published: February 2017

ABSTRACT
Spontaneous biliary fistulae are encountered, not very rarely, in one's surgical practice. These fistulae are of three types: Internal, external, and combined. Internal spontaneous biliary fistulae are the commonest. External fistulae could be spontaneous or because of therapeutic, iatrogenic, or traumatic reasons are extremely rare. Spontaneous cholecystocutaneous fistula (SCCF), secondary to calculous cholecystitis, is an extremely rare presentation in the present-day scenario. It used to be quite common before the year 1900, but is very rare now because of better management of cholecystitis and cholelithiasis. Usually, SCCF is a complication of neglected chronic cholelithiasis. This is seldom seen today because of the early diagnosis and better management made feasible by ultrasound as first-line investigation, broad spectrum antibiotics, and effective surgical management of biliary tract diseases. It is a very rare case of 35-year-old female patient presenting in the outpatient department, with the multiple stones carefully preserved, which she had been extruding through the fistulous opening in the umbilicus, for the last 1 year. She was investigated and was operated for the same condition. Though the entity is very rare, clinicians should keep this condition in mind while examining any case of chronic discharging sinus or fistula on the abdominal wall, particularly the wound extruding stones in which case the diagnosis is selfrevealing. In the absence of positive history of expelling stones, the diagnosis can be confirmed by computerized tomogram fistulography. Though the early diagnosis and improvement in the management of gallbladder disease has improved tremendously, the possibility of this condition arising mostly from the neglected gallbladder disease should always be kept in mind as such cases are again being reported from all over the world.

How to cite this article
Abbey R. Spontaneous Cholecystocutaneous Fistula. Int J Adv Integ Med Sci 2016; 1(4):196-198.
Identification, Characterization, and Quantification of Impurities of Safinamide Mesilate: Process-Related Impurities and Degradation Products
Authors: Zou Liang , Sun Lili , Zhang Hui , Hui Wenkai , Zou Qiaogen , Zhu Zheying 
Published: February 2017

Abstract
The characterization of process-related impurities and degradation products of safinamide mesilate (SAFM) in bulk drug and a stability-indicating HPLC method for the separation and quantification of all the impurities were investigated. Four process-related impurities (Imp-B, Imp-C, Imp-D, and Imp-E) were found in the SAFM bulk drug. Five degradation products (Imp-A, Imp-C, Imp-D, Imp-E, and Imp-F) were observed in SAFM under oxidative conditions. Imp-C, Imp-D, and Imp-E were also degradation products and process-related impurities. Remarkably, one new compound, identified as (S)-2-[4-(3-fluoro-benzyloxy) benzamido] propanamide (i.e., Imp-D), is being reported here as an impurity for the first time. Furthermore, the structures of the aforementioned impurities were characterized and confirmed via IR, NMR, and MS techniques, and the most probable formation mechanisms of all impurities proposed according to the synthesis route. Optimum separation was achieved on an Inertsil ODS-3 column (250 × 4.6 mm, 5 μm), using 0.1% formic acid in water (pH adjusted to 5.0) and acetonitrile as the mobile phase in gradient mode. The proposed method was found to be stability-indicating, precise, linear, accurate, sensitive, and robust for the quantitation of SAFM and its process-related substances, including its degradation products.
Petite philosophie d’André Belleau
Authors: Rondeau Frédéric 
Published: February 2017

Il est souvent question de Roland Barthes dans les essais et les carnets d’André Belleau. C’est le sémiologue, le critique de Tel quel et le penseur du structuralisme que ce dernier évoque. Belleau s’inspire des écrits de Barthes (et de ceux de Jean Marcel) pour développer son « essayistique », mais aussi, sans doute, pour s’accorder une légitimité d’écrivain. Belleau considère que « l’écrivain est […] celui qui travaille le discours social » (« Approches et situation de l’essai québécois », Y a-t-il un intellectuel dans la salle ?), et ce sont d’abord les « signes du réel » qui retiennent son attention, comme celle de Barthes. Tous deux partagent en outre une passion pour les formes courtes (l’essai, la nouvelle, la chanson). Or, au-delà de ces rapprochements, c’est surtout leur rapport au politique qui nous intéressera, celui-ci paraissant indissociable de leur conception même de l’écriture. Pour André Belleau, l’écriture exige une forme de retrait, une mise en perspective et l’expression d’une singularité prenant forme autour de la question suivante : « Comment être manifestement solidaire du groupe dans la distance ? » (« Petite grammaire de la solidarité avec le peuple », Y a-t-il un intellectuel dans la salle ?) C’est une interrogation semblable que l’on retrouve chez Barthes lorsqu’il élabore les notions « d’impersonnel » et de « neutre ». Cet article visera à établir des parallèles entre la politique mise en oeuvre par ces auteurs et l’importance qu’ils accordent au style, à une certaine forme de « plaisir du texte » et de souplesse de la pensée.
Le théorique, la politique, Bakhtine et la sociocritique
Authors: Popovic Pierre 
Published: February 2017

Précoce introducteur des travaux de Mikhaïl Bakhtine dans le monde occidental des
études de lettres, André Belleau a entretenu avec la théorie littéraire une relation
curieuse, gourmande, passionnée, toujours orientée vers ce qui l’intéressait le plus :
transformer le texte de littérature en question de manière à le rendre susceptible
d’éclairer un peu le monde tel qu’il est connu au moment où il y fait son apparition. Mais
ce rapport au théorique est aussi un rapport complexe, où entrent parfois de
l’insatisfaction, des désirs irréalisés de dépassement, du malaise. L’étude en cherche
l’origine et la trouve à la fois du côté politique et du côté de l’émergence d’une
problématique que le destin ne lui a pas permis de développer, celle des relations entre la
culture populaire et la culture savante. Nul doute qu’elle l’aurait conduit à élaborer
lui-même des concepts propres à son traitement.
Papineau, « celui qui n’écrit pas »
Authors: Livernois Jonathan 
Published: February 2017

Cette étude s’attache à la présence de Louis-Joseph Papineau dans les manuels et essais d’histoire littéraire du Québec ainsi qu’aux incidences idéologiques de sa représentation en tant qu’écrivain. Elle s’attache, notamment, au Manuel d’histoire de la littérature canadienne-française (1918 et 1939) et à l’Histoire de la littérature canadienne (1930) de Mgr Camille Roy ; à l’Histoire de la littérature canadienne-française (1957) de Samuel Baillargeon ; au Manuel de littérature canadienne-française (1967) de Roger Duhamel ; à l’Histoire de la littérature française du Québec, en quatre volumes (Beauchemin, 1967-1969), dirigée par Pierre de Grandpré ; à La littérature québécoise depuis ses origines (1974-1997) de Laurent Mailhot ; à La vie littéraire au Québec (premier volume paru en 1991) ; et à l’Histoire de la littérature québécoise (2007) de Michel Biron, François Dumont et Élisabeth Nardout-Lafarge. Nous verrons s’y jouer les stratégies alternatives d’intégration et de refus de la charge symbolique et politique de « l’écrivain » Papineau. Cela permettra de mieux comprendre pourquoi ces stratégies sont étonnamment récurrentes au fil de l’histoire littéraire, malgré les tours et détours idéologiques et historiographiques du xxe siècle.
The Upturned Superior Mesenteric Artery Sign for First‐Trimester Detection of Congenital Diaphragmatic Hernia and Omphalocele
Authors: Lakshmy Ravi Selvaraj , Agnees Joy , Rose Nity 
Published: February 2017

ObjectivesThe aim of this study was to follow the course of the superior mesenteric artery (SMA) in first‐trimester fetuses to predict the location of the small bowel. Its abnormal course aids in early detection of congenital diaphragmatic hernia (CDH) and assessment of the contents of omphalocele.MethodsThe SMA can be easily identified in a sagittal section of the fetus by using color Doppler sonography at the 11‐ to 14‐week scan, and normally, it has a downward course caudally to supply the intestines. The course of the SMA points to the location of the bowel.ResultsWe report a series of 7 cases detected in first trimester with an abnormal course of the SMA, 3 of which had CDH and 4 of which had omphalocele. In CDH, the intestines herniate into the thoracic cavity; hence, the SMA tends to have an upward course toward the thorax. In 4 cases of omphalocele, the SMA follows the exteriorized bowel into the base of the umbilical cord.ConclusionsSecond‐trimester sonography for detection of congenital malformations is a standardized protocol, but a careful anatomic survey at the 11‐ to 14‐week scan is often rewarding. When there is a suspicion of an intrathoracic mass or a mediastinal shift, the upturned course of SMA serves as a valuable sign in confirmation of CDH. Chromosomal abnormalities are often reported in cases of omphalocele containing small bowel only, and the upward course of the SMA toward the base of the cord helps in its early prenatal diagnosis, which facilitates early genetic assessment in these fetuses.
Laboratory generation of broadband ELF waves by inhomogeneous plasma flow
Authors: Liu Yu , Lei Jiuhou , Yu Pengcheng , Zhang Zhongkai , Zhang Xiao , Cao Jinxiang 
Published: February 2017

AbstractTransversely accelerated ions and the associated heating of the high‐latitude ionosphere have been attributed to broadband extremely low frequency (BBELF) turbulence. Controlled laboratory tests of the hypotheses on the formation mechanism of BBELF waves have involved only a few examples, e.g., current‐driven and shear‐driven instabilities. In this work, electrostatic fluctuations in the ion cyclotron frequency range have been excited by inhomogeneous energy‐density‐driven instability (IEDDI). This was achieved using the interpenetrating plasma method with a much larger electric field scale size LE comparable to the ion gyroradius ρi, which was challenging earlier because of plasma conditions. The peak frequency of the IEDDI spectrum falls as low as ω≈0.3ωci, where ωci is ion cyclotron frequency. This is an interesting result because the previous attempts could not produce such low‐frequency IEDDI, although it was known theoretically to be possible. The observations made by FAST, Freja, and Time History of Events and Macroscale Interactions during Substorms (THEMIS) satellites might be explainable in terms of the reported experimental results.
Erosion of modern terrestrial organic matter as a major component of sediments in fjords
Authors: Cui Xingqian , Bianchi Thomas S. , Savage Candida 
Published: February 2017

AbstractFjords have recently been recognized as “hot spots” of carbon burial. In this study, we investigated organic carbon (OC) and biomarker radiocarbon values in fjord sediments from New Zealand. Our results showed that OC was mostly modern with the most aged OC in middle reaches of fjords, likely related to hydrodynamic sorting and inputs along adjacent slopes. Radiocarbon ages of sedimentary OC increased from north‐to‐south, consistent with the Fiordland regional gradients of lower fjord slopes and less rainfall. Our biomarker results suggested that lignin and long‐chain fatty acids were preferentially linked with fresh terrestrial debris and degraded soil, respectively, likely due to their chemical and physical properties. Finally, we propose that fjords are a significant sink of modern OC, in contrast to large lowland coastal systems as a major sink of preaged OC. Overall, this study indicated that radiocarbon techniques are critical in investigating carbon dynamics in coastal systems.
Characterizing the ionospheric current pattern response to southward and northward IMF turnings with dynamical SuperMAG correlation networks
Authors: Dods J. , Chapman S. C. , Gjerloev J. W. 
Published: February 2017

AbstractWe characterize the response of the quiet time (no substorms or storms) large‐scale ionospheric transient equivalent currents to north‐south and south‐north IMF turnings by using a dynamical network of ground‐based magnetometers. Canonical correlation between all pairs of SuperMAG magnetometer stations in the Northern Hemisphere (magnetic latitude (MLAT) 50–82°) is used to establish the extent of near‐simultaneous magnetic response between regions of magnetic local time‐MLAT. Parameters and maps that describe spatial‐temporal correlation are used to characterize the system and its response to the turnings aggregated over several hundred events. We find that regions that experience large increases in correlation post turning coincide with typical locations of a two‐cell convection system and are influenced by the interplanetary magnetic field By. The time between the turnings reaching the magnetopause and a network response is found to be ∼8–10 min and correlation in the dayside occurs 2–8 min before that in the nightside.