bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doctores en proyectos
Authors: Peñín Llobell Alberto 
Published: November 2017

PALIMPSESTO ha realizado un análisis de las tesis de tres
Departamentos de Proyectos (ETSAM, ETSAB-V, ETSAV) leídas durante el último curso académico 2015-2016, en el que se ha producido una oleada sin precedentes en la defensa de trabajos de doctorado
PALIMPSESTO has made an analysis of the wave of thesis that have been defended during the last academic year 2015-2016 in three Departments of Design (ESTAM,
ETSAB-V, ESTAV), due to the changes in regulations.
Manufactura digital: reconsideraciones teóricas y operativas en torno al ejercicio proyectual contemporáneo.
Authors: Corvalán Tapia Felipe Andrés 
Published: November 2017

La integración de las fases de diseño, representación y fabricación que la tecnología digital permite, abre nuevas posibilidades al proyecto, reemplazando un proceso secuencial por otro simultáneo. Una simultaneidad que se vincula con una concepción artesanal y pre-moderna de la arquitectura. Los sistemas CAD/CAM establecen un puente de conexión interactivo entre la mente y la mano, entre creación y producción, posibilitando un desarrollo colaborativo del proyecto, desafiando la tradicional noción de autoría. Los puntos de contacto entre el trabajo artesanal y estas innovadoras tecnologías, permiten pensar a estas últimas como una suerte de manufactura digital, capaz de re-significar el vínculo entre conocimiento (software) y materialización (hardware), entre teoría y práctica . En este contexto, la presente investigación plantea una reflexión sobre las implicancias –teóricas y operativas– que esta incorporación tecnológica tiene o puede tener sobre la arquitectura y su desarrollo disciplinar, considerando además los desafíos planteados por la realidad contemporánea.
The integration between design, representation and fabrication that digital technology allows, opens up new possibilities for the project. Thus simultaneous processes
replace the traditionally sequential processes. This simultaneity can be linked to a pre-modern architectural conception. The CAD/CAM systems connect mind and
hand, creation and production. This allows a collaborative working within the project, reshaping the author’s concept.
The connection between craftwork and these new technologies permits to think of these technologies as a kind of digital manufacturing; capable of re-signifying the link between knowledge (software) and materialization
(hardware), between theory and practice. In this context, the following research proposes a theoretical and operational discussion about the technological implications on architecture and its disciplinary development, considering
also the challenges of contemporary reality.
Concurso Internacional Museo del Prado
Authors: - Foster and Partners , - Rubio Arquitectura 
Published: November 2017

Foster + Partners y Rubio Arquitectura han ganado
el concurso internacional para la revitalización y
remodelación del histórico Salón de Reinos, que
se incorporará al Campus Prado en Madrid.
El diseño aspira a crear un nuevo foco urbano donde
todos los edificios que constituyen el Campus
Prado quedarán reunidos y enlazados mediante espacios
públicos y uniones subterráneas.
El Salón de Reinos es uno de los fragmentos
supervivientes del que fuera el Palacio del Buen Retiro,
del s. XVII, y ha sido objeto de numerosos cambios y
adiciones, acumulando varios estratos de historia
a lo largo de los siglos.
Las intervenciones que se plantean devolverán la vida a
los magníficos interiores del pasado y
añadirán novedosas salas de exposiciones y espacios
públicos. La propuesta se remonta cuatro siglos
F atrás para redescubrir la fachada original en tres niveles, y constituye la base sobre la cual alojar un
nuevo y espectacular espacio. Los muros exteriores han
sido delicadamente ampliados para introducir
la luz y establecer un vínculo con la nueva plaza cívica.
Foster + Partners and Rubio Arquitectura have won the international competition to revitalise and refurbish the historic Hall of Realms (Salón de Reinos) as a new addition to the Museo del Prado campus in Madrid.
The vision is to create a new public focus for the city by bringing together the various buildings that comprise the Prado with public spaces and underground links.
The Hall of Realms is a noble structure and one of the very few that have survived from the former Palacio del Buen Retiro of the seventeenth century. It has been the
subject of changes and expansion, gathering many layers of history over the centuries.
The interventions will bring fresh life to the magnificent interiors from the past as well as adding new state-of-the-art galleries and public spaces. The proposal goes back four centuries to re-discover the original three
storey southern façade. This becomes the backdrop for a spectacular new space within the building. The existing outer walls have been delicately opened up to bring light
and views in from the new civic plaza.
Worldwide Frequency of Commonly Detected EGFR Mutations
Authors: Graham Rondell P. , Treece Amanda L. , Lindeman Neal I. , Vasalos Patricia , Shan, Mu , Jennings Lawrence J. , Rimm David L. 
Published: November 2017

Context.—
Recurrent epidermal growth factor receptor (EGFR) mutations are seen in a subset of pulmonary adenocarcinomas. These mutations are targeted by EGFR inhibitors and are a biomarker for response to EGFR inhibitor therapies. Initial data have indicated an increased frequency of activating EGFR mutations in nonsmoking Asian females. However, there are very few studies of global scope that address the question of mutation distribution across the population of lung cancer.

Objective.—
To determine the frequency of EGFR mutations in exons 18 through 21 detected in clinical laboratories participating in the College of American Pathologists proficiency testing program for EGFR in calendar year 2013.

Design.—
We reviewed the surveys from 170 clinical laboratories from 20 countries that participated in the College of American Pathologists EGFR proficiency testing program. The proficiency testing includes questions regarding the total numbers of tests performed at each common mutation site, including both activating and resistance mutations, and their frequency. Countries were grouped into regional groups in order to assess frequency of mutation by type, and to indirectly assess ethnic differences in mutation frequencies.

Results.—
Among the treatment-sensitive activating mutations, the most common are exon 19 mutations (n = 10 802 of 136 533 cases; 7.9% of total cases tested) and the exon 21 L858R mutation (n = 10 351 of 136 533 cases; 7.6% of total cases tested) and the least common are exon 20 mutations (n = 466 of 136 533 cases; 0.3% of total cases tested). The T790M mutation in exon 20 is the more common resistance mutation (n = 1010 of 136 533 cases; 0.7% of all cases tested). The highest activating mutation frequency is seen in southern Asia (n = 4260 of 9337 cases; 46%) and the lowest activating mutation frequencies are in South and North America (n = 113 of 1439 cases and 7926 of 86 654 cases; 8% and 9%, respectively).

Conclusions.—
Our data confirm that activating EGFR mutations are more common in southern Asia and that the distribution of activating EGFR mutations varies significantly across the regions. Similarly, the frequency and distribution of resistance mutations also show significant variation when comparing southern Asia with other regions.
Reducing Bidirectional Pedestrian Conflict Based on Lane Formation Phenomenon in Subway Corridors
Authors: Qiao Jing , Sun Lishan , Qiu Shi , Rong Jian , Liu Xiaoming 
Published: November 2017

With the rapid increase of the subway passenger volume, the conflict among passengers emerges as a significant issue which affects subway serviceability, especially in the bidirectional flow. The aim of this study is to explore the characteristics of the bidirectional flow of pedestrians in a subway corridor. Pedestrian experiments were conducted to investigate microscopic characteristics of the pedestrian flow. It was found that the microscopic characteristics, including the walking speed and turning angle, were time-dependent and had a generalized trend with time. It was also found that different pedestrian volumes affected the microscopic characteristics. Based on the trend of the microscopic characteristics, the lane formation phenomenon was observed and quantitatively studied, identifying three phases: conflict phase, lane formation phase, and steady lane phase. To alleviate the bidirectional pedestrian conflict, additional pedestrian experiments for the countermeasure of adding separating strap in the corridor, which was based on the lane formation analysis, was conducted. The effectiveness of the countermeasure was demonstrated through a before-and-after comparison. The results showed that adding the separation between the adjacent lanes had the best performance in reducing the conflicts. The results would provide a rationale for subway managers in optimizing the corridor bidirectional pedestrian flow.
Investigating the Applicability of Upstream Detection Strategy at Pedestrian Signalised Crossings
Authors: Hassan Sitti A , Hounsell Nick B , Shrestha Birendra P 
Published: November 2017

In the UK, the Puffin crossing has provision to extend pedestrian green time for those who take longer to cross. However, even at such a pedestrian friendly facility, the traffic signal control is usually designed to minimise vehicle delay while providing the crossing facility. This situation is rather contrary to the current policies to encourage walking. It is this inequity that has prompted the need to re-examine the traffic control of signalised crossings to provide more benefit to both pedestrians and vehicles. In this context, this paper explores the possibility of implementing an Upstream Detection strategy at a Puffin crossing to provide a user friendly crossing. The study has been carried out by simulating a mid-block Puffin crossing for various detector distances and a number of combinations of pedestrian and traffic flows. This paper presents the simulation results and recommends the situations at which Upstream Detection would be suitable.
Container Throughput Forecasting Using Dynamic Factor Analysis and ARIMAX Model
Authors: Intihar Marko , Kramberger Tomaž , Dragan Dejan 
Published: November 2017

The paper examines the impact of integration of macroeconomic indicators on the accuracy of container throughput time series forecasting model. For this purpose, a Dynamic factor analysis and AutoRegressive Integrated Moving-Average model with eXogenous inputs (ARIMAX) are used. Both methodologies are integrated into a novel four-stage heuristic procedure. Firstly, dynamic factors are extracted from external macroeconomic indicators influencing the observed throughput. Secondly, the family of ARIMAX models of different orders is generated based on the derived factors. In the third stage, the diagnostic and goodness-of-fit testing is applied, which includes statistical criteria such as fit performance, information criteria, and parsimony. Finally, the best model is heuristically selected and tested on the real data of the Port of Koper. The results show that by applying macroeconomic indicators into the forecasting model, more accurate future throughput forecasts can be achieved. The model is also used to produce future forecasts for the next four years indicating a more oscillatory behaviour in (2018-2020). Hence, care must be taken concerning any bigger investment decisions initiated from the management side. It is believed that the proposed model might be a useful reinforcement of the existing forecasting module in the observed port.
Collision Avoidance via Adaptive Trajectory Control in Case of a Sudden Decrease in the Maximum Road Friction Coefficient
Authors: Şahin Hasan 
Published: November 2017

This study analyses an Adaptive Trajectory Control (ATC) system in case of a sudden change in μ-max (maximum tyreroad friction coefficient) during an emergency lane change manoeuvre in order to maintain the driving safety. Autonomous front wheel steering (FWS) systems have been developed for emergency steering situations. The trajectory design is also a part of these systems. Moreover, in this study ATC has been designed by sensing μ-max to complete the emergency steering manoeuvre successfully. Therefore, the originality of this paper arises from the necessity of a trajectory change in case of a sudden change in μ-max to minimize the distance between the desired and the actual path. Suitable cases were designed by using a two-track model in IPG/CarMaker (MATLAB/Simulink). Results show that ATC could be used during an emergency steering manoeuvre in case of a sudden decrease in μ-max as it can be advantageous in certain critical traffic situations. Therefore, ATC could beused as an alternative system instead of Electronic Stability Program.
Comment on “Radiative Transfer in CO2‐Rich Atmospheres: 1. Collisional Line Mixing Implies a Colder Early Mars”
Authors: Turbet M. , Tran H. 
Published: November 2017

AbstractOzak et al. (2016) claimed that explicitly including the effect of CO2 collisional line mixing in their radiative transfer calculations yield CO2 atmospheres that are more transparent to infrared radiation than when spectra calculations are made using sub‐Lorentzian line shapes. This would in particular imply significantly colder surface temperatures (up to 15 K) for early Mars than estimated in previous studies. Here we show that the relative cooling that Ozak et al. (2016) associated to the effect of collisional line mixing is in fact due to a wrong choice of broadening species (air instead of CO2). We then calculated line‐by‐line spectra of pure CO2 atmospheres using a line‐mixing model developed for self‐broadened CO2. Using the LMD Generic model (in 1‐D radiative‐convective mode), we find that calculations made with the proper collisional line mixing model and with sub‐Lorentzian line shapes lead to differences between early Mars surface temperatures smaller than 2 K only.
Assessment and Construction of Designed Experiments
Authors: Anderson‐Cook Christine M. , Lu Lu 
Published: November 2017

AbstractCollecting data as part of a designed experiment involves choices between different candidate designs. The criteria for choosing between these designs involve many competing objectives that frequently force us to make trade‐offs based on which of these ideal characteristics of the design we think are most important. Optimality criteria are single‐number summaries for the “goodness” of the design, which typically focus on the quality of estimation or prediction. In addition to these measures, the robustness of the design to model misspecification, problems with data collection during the experiment, or erroneous data are also important. A number of the characteristics of good designs are outlined and compared, and some graphical methods for better understanding the performance of a design are shown. Simultaneously, considering multiple criteria is helpful to maximize the gain of information from the experiment. Given the trade‐offs between different aspects of design performance including the size of the experiment, using a structured approach for guiding the evaluation and comparison can help facilitate discussion for making an informed and tailored decision that matches the goals of a particular experiment.
K
ullback–
L
eibler Information
Authors: Claeskens Gerda 
Published: November 2017

Abstract
The Kullback–Leibler information number, , determined for two probability measures defined on the same measurable space, often serves as a type of “distance” between the two measures. Projections (‐projections) defined in terms of minimizing the Kullback–Leibler information number over appropriate sets of probability measures are often useful for finding desirable estimators. Kullback–Leibler information numbers also play a useful role in hypothesis testing problems, and they are the basis for several information criteria used for model selection.
Targeted Minimum Loss‐Based Estimation
Authors: van der Laan Mark J. , Benkeser David , Sofrygin Oleg 
Published: November 2017

AbstractStatistical models that accurately reflect scientific knowledge are often, by necessity, infinite‐dimensional. Estimation of smooth parameters using standard estimation techniques in such models is problematic. For example, maximum likelihood estimators often behave poorly in large models due to the fact that such estimators trade off bias and variance with respect to estimation of the density of the observed data, while the target parameter is a low‐dimensional summary measure of this density. To obtain valid estimators in these situations, we must tailor the estimation procedure to the parameter of interest. Targeted minimum loss‐based estimation (TMLE) provides a template for constructing well‐behaved estimators of smooth parameters in infinite‐dimensional models. TMLE estimators are not only asymptotically consistent and normally distributed but also are designed to exhibit robust finite‐sample performance. The remainder of this article provides an introduction to the TMLE procedure and discusses recent advances in the field of targeted learning.
Proteomic Analysis of Post‐Translational Modifications by Mass Spectrometry
Authors: Gruhler Albrecht , Jensen Ole N. 
Published: November 2017

AbstractThe sections in this article areSummaryIntroductionConsiderations for the Experimental Design ofPTMAnalysis by ProteomicsAnalysis ofPTMsby Proteomic ApproachesConclusions and PerspectivesAcknowledgements
Proteomics of Disulphide and Cysteine Oxidoreduction
Authors: Maeda Kenji , Hägglund Per , Finnie Christine , Svensson Birte 
Published: November 2017

AbstractThe sections in this article areIntroductionControl of Cellular Redox StatusProteomics Techniques for Analysis of Cysteine ModificationsConclusions and PerspectivesAcknowledgements
Surveying the Plant Cell Wall Proteome, or Secretome
Authors: Isaacson Tal , Rose Jocelyn K.C. 
Published: November 2017

AbstractThe sections in this article areIntroductionThe Multifunctional Cell WallTechnical and Conceptual Challenges in Defining the Cell Wall Proteome, or SecretomeApproaches for Plant Cell Wall Protein Extraction and IdentificationComputational Prediction of the Plant SecretomeFunctional Screens for Extracellular ProteinsContamination and Validation of the Cell Wall ProteomeConclusions
General Transcription Factors and the Core Promoter: Ancient Roots
Authors: Gurley William B. , O'Grady Kevin , Czarnecka‐Verner Eva , Lawit Shai J. 
Published: November 2017

AbstractThe sections in this article areIntroductionOrigins of the Eukaryotic PromoterOrganization of the Eukaryotic PromoterTranscription FactorIIDRole ofTFIIDin DevelopmentMediatorTranscription FactorIIBSummary
Matrix Attachment Regions and Transcriptional Gene Silencing
Authors: Thompson William F. , Spiker Steven , Allen George C. 
Published: November 2017

AbstractThe sections in this article areIntroductionCosts and Consequences of Transgene Expression VariationPosition EffectsGene SilencingMatrix Attachment RegionsMARsand Transgene ExpressionMAREffects inArabidopsisConclusions
Combinatorial Control of Floral Organ Identity by
MADS
‐Domain Transcription Factors
Authors: Theißen Günter , Melzer Rainer 
Published: November 2017

Abstract
The sections in this article are

Introduction

ABC
: Early Genetic Models of Floral Organ Identity

From the
ABC
to the
ABCDE
Model

Elective Affinities of Homeotic Proteins: The Floral Quartet Model

Beyond the Floral Quartets
Sensu Stricto
: Multimeric Complexes of Other
MIKC
‐Type Proteins

Outlook: The Devil is Always in the Details – What We Still Don't Know about Floral Quartets

Summary

Acknowledgments
Outgrowing the laboratory diagnosis of type 1 von Willebrand disease: A two decade study
Authors: Abou‐Ismail Mouhamed Yazan , Ogunbayo Gbolahan O. , Secic Michelle , Kouides Peter A. 
Published: November 2017

AbstractVon Willebrand Factor (VWF) levels are known to increase with age in the general population, but that effect is unclear in von Willebrand disease (VWD) patients. Thus, it is important to assess the trends of VWF levels with age, and the extent and rate of their normalization in patients with VWD. In a retrospective cohort study, we reviewed the medical records of 126 patients between 1996 and 2016 who met the NHLBI diagnostic criteria for type 1 VWD or “Low VWF” (LVWF). We followed all their historically documented VWF antigen (VWF:Ag), VWF activity (VWF:RCo), and Factor VIII (FVIII) levels longitudinally over time, correlating data with clinical setting at time of testing. The average duration of follow‐up was 10.5 ± 3.7 years (SD). Out of the total study population, 27.8% achieved the primary outcome of complete normalization (CN) of both VWF:Ag and VWF:RCo levels, including 19.6% and 32.5% of those with VWD and LVWF, respectively. Linear regression demonstrated statistically significant positive trends of VWF:Ag, VWF:RCo, FVIII with time, calculated at 2.4, 1.4, and 1.4 U dL‐1/year, respectively (P < .001 each). In the largest study population of VWD patients to date whose levels were followed longitudinally, there is a statistically significant rise in VWF:Ag, VWF:RCo, and FVIII levels observed with time. CN of both VWF:Ag and VWF:RCo levels was observed in almost a third of patients with VWD or LVWF, over an average of 10 years. Whether the bleeding phenotype also improves is unclear and requires further study.
Solvent‐free, l‐Leucine‐Catalyzed Direct Dehydrative Esterification of Carboxylic Acids with Alcohols: Direct Synthesis of 3‐Alkoxy 1(3 H)‐isobenzofuranone
Authors: Kumar Manoranjan , Thakur Krishna , Sharma Sushila , Nayal Onkar S. , Kumar Neeraj , Singh Bikram , Sharma Upendra 
Published: November 2017

AbstractA l‐leucine‐catalyzed mild and efficient method has been developed for the synthesis of open‐chain as well as cyclic esters. A wide range of alcohols, including primary, secondary, and tertiary with aliphatic and aromatic side chains, were successfully tolerated. In the case of 2‐carboxybenzaldehydes with different alcohols, 3‐alkoxy‐1‐(3 H)‐isobenzofuranones were obtained in good yields. Alcohols from natural origin have also been reacted with various acids successfully to get the corresponding esters. The reaction proceeded under neat conditions and there is no need for any acid, base, or removal of water during the reaction.
Synthesis of Chiral Acyclic Pyrimidine Nucleosides with a Sulfur‐Containing Side Chain via Enantioselective Tandem Conjugate Addition/Protonation
Authors: Li Jian‐Ping , Tuo Hao‐Ran , Xie Ming‐Sheng , Kang Bo , Qu Gui‐Rong , Guo Hai‐Ming 
Published: November 2017

AbstractA direct route to chiral pyrimidine acyclic nucleoside analogues with a sulfur‐containing side chain is reported via enantioselective tandem conjugated addition‐protonation reactions of thioacetic acid to α‐pyrimidine substituted acrylates. In the presence of a quinine‐derived thiourea catalyst, diverse chiral sulfur‐containing pyrimidine acyclic nucleoside analogues could be obtained in excellent yields (95–99 %) and with moderate to excellent enantioselectivity values (up to 99 % ee).
Efficient Encapsulation of Fluorinated Drugs in the Confined Space of Water‐Dispersible Fluorous Supraparticles
Authors: Pigliacelli Claudia , Maiolo Daniele , Nonappa  , Haataja Johannes S. , Amenitsch Heinz , Michelet Claire , Sánchez Moreno Paola , Tirotta Ilaria , Metrangolo Pierangelo , Baldelli Bombelli Francesca 
Published: November 2017

AbstractFluorophobic‐driven assemblies of gold nanomaterials were stabilized into water‐dispersible fluorous supraparticles by the film‐forming protein hydrophobin II. The strategy makes use of fluorous nanomaterials of different dimensions to engineer size and inner functionalization of the resulting confined space. The inner fluorous compartments allow efficient encapsulation and transport of high loadings of partially fluorinated drug molecules in water.