bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of tourniquet number and exsanguination on amikacin concentrations in the radiocarpal and distal interphalangeal joints after low volume intravenous regional limb perfusion in horses
Authors: Schoonover Mike J. , Moser Darla K. , Young Jenna M. , Payton Mark E. , Holbrook Todd C. 
Published: May 2017

AbstractObjectiveTo determine the influence of a dual tourniquet technique and limb exsanguination on amikacin concentrations in the synovial fluid of the radiocarpal joint (RCJ) and distal interphalangeal joint (DIPJ) after low volume, cephalic intravenous regional limb perfusion (IVRLP).Study designRandomized cross‐over design.AnimalsSix healthy adult horses.MethodsOne gram of amikacin in 6 mL of 0.9% NaCl was infused via cephalic IVRLP in 6 standing, sedated horses using 4 techniques: proximal pneumatic tourniquet (P), proximal pneumatic tourniquet with exsanguination (PE), proximal pneumatic and distal Esmarch tourniquet (PD), and proximal pneumatic with distal Esmarch tourniquet and exsanguination (PDE). Amikacin concentrations were measured in RCJ and DIPJ synovial fluid samples, collected just before perfusion (time 0), and at 15 and 30 minutes (before tourniquet release) after perfusion.ResultsSynovial fluid amikacin concentrations achieved in the RCJ were higher with techniques PD and PDE than those achieved with techniques P and PE 15 and 30 minutes after perfusion (P < .0001). Synovial fluid amikacin concentrations in the DIPJ were higher with techniques P and PE than those achieved with techniques PD and PDE at 15 minutes (P = .0002) and were higher than technique PDE at 30 minutes after perfusion (P < .0001).ConclusionLow volume (10 mL) cephalic IVRLP should be combined with the placement of 2 tourniquets (proximal and distal to the carpus) to achieve therapeutic amikacin concentrations in the RCJ. Exsanguination prior to low volume IVRLP does not alter synovial fluid amikacin concentrations.
Laparoscopic evaluation of the small intestine in the standing horse: Technique and effects*
Authors: Jones Andrew R. E. , Ragle Claude A. , Anderson Dusty , Scott Coryelle 
Published: May 2017

AbstractObjectiveTo evaluate the feasibility and clinical outcomes after laparoscopic evaluation of the small intestines via laparoscopy.Study DesignProspective pilot study.AnimalsHealthy adult horses (n = 5).MethodsHorses were restrained in standing stocks and received an infusion of detomidine. One port was placed in the left last intercostal space and 3 ports were placed in the right paralumbar fossa. The small intestine was run with atraumatic laparoscopic grasping forceps, from the duodenocolic plica to the ileocecal plica. Postoperative pain was scored every 4 hours for the first 48 hours. Horses were monitored via physical examinations for 2 weeks. Second look laparoscopy was repeated at 2 weeks, to run the small intestine and assess iatrogenic changes. An exploratory celiotomy was performed in 2 horses, 2 months later and long‐term follow‐up was recorded in 3 horses.ResultsLaparoscopic evaluation of the entire small intestine was successfully completed twice in every horse. This evaluation lasted 39 ± 21.2 minutes (mean ± SD), while total surgery time was 73 ± 34.1 minutes. Postoperative physical examinations remained normal in all horses, and pain scores were scored as mild. The only abnormalities at second look laparoscopy consisted of multifocal petechiae and ecchymoses in all horses, resolved by 2 months in the 2 horses explored via celiotomy. Three horses with long‐term follow‐up were healthy 8 months after the study.ConclusionRunning the small intestine laparoscopically is a feasible procedure in standing normal horses, and does not cause significant discomfort nor complications.
Shaved margin histopathology and imprint cytology for assessment of excision in canine mast cell tumors and soft tissue sarcomas
Authors: Milovancev Milan , Townsend Kaitlin L. , Gorman Elena , Bracha Shay , Curran Katie , Russell Duncan S. 
Published: May 2017

AbstractObjectiveTo determine the feasibility and agreement of margin assessment by imprint cytology, shaved margin histopathology, and radial section histopathology in canine cutaneous and subcutaneous mast cell tumors (MCT) and soft tissue sarcomas (STS).Study designProspective clinical study.Sample populationThree hundred and forty margins from 72 excised tumors (52 MCT and 20 STS) in 54 client‐owned dogs.MethodsImprint cytology samples were acquired by pressing glass slides to the cut surgical margin of the freshly excised surgical specimen. Shaved margin samples were obtained from the patient wound bed using a scalpel immediately prior to closure. Radial section histopathology was performed as part of routine histopathologic processing. All margins were assessed as either positive or negative for presence of tumor cells at the surgical margin. Agreement among methods was calculated using Fleiss Kappa coefficients and an association of method, margin direction, and tumor type with positive margin status was evaluated using a general linear mixed model.ResultsPositive margin detection rates differed for MCT (imprint cytology 21%, radial section histopathology 9%, and shaved margin histopathology 3%;P < .0001) but not for STS. Intermethod agreement was poor (Fleiss Kappa = 0.051 and 0.176 for MCT and STS, respectively). Margin direction did not influence margin status for either tumor type.ConclusionImprint cytology and shaved margin histopathology are feasible, but their results are frequently disparate from routine radial section histopathology. Future studies are needed to evaluate the correlation of each method with local recurrence rates.
Is There an Optimal Speed for Economical Running?
Authors: Black Matthew I. , Handsaker Joseph C. , Allen Sam J. , Forrester Stephanie E. , Folland Jonathan P. 
Published: May 2017

The influence of running speed and sex on running economy is unclear and may have been confounded by measurements of oxygen cost that do not account for known differences in substrate metabolism, across a limited range of speeds, and differences in performance standard. Therefore, this study assessed the energy cost of running over a wide range of speeds in high-level and recreational runners to investigate the effect of speed (in absolute and relative terms) and sex (men vs women of equivalent performance standard) on running economy. To determine the energy cost (kcal · kg−1 · km−1) of submaximal running, speed at lactate turn point (sLTP), and maximal rate of oxygen uptake, 92 healthy runners (high-level men, n = 14; high-level women, n = 10; recreational men, n = 35; recreational women, n = 33) completed a discontinuous incremental treadmill test. There were no sex-specific differences in the energy cost of running for the recreational or high-level runners when compared at absolute or relative running speeds (P > .05). The absolute and relative speed–energy cost relationships for the high-level runners demonstrated a curvilinear U shape with a nadir reflecting the most economical speed at 13 km/h or 70% sLTP. The high-level runners were more economical than the recreational runners at all absolute and relative running speeds (P < .05). These findings demonstrate that there is an optimal speed for economical running, there is no sex-specific difference, and high-level endurance runners exhibit better running economy than recreational endurance runners.
Injury Patterns, Physiological Profile, and Performance in University Rugby Union
Authors: Ball Shane , Halaki Mark , Sharp Tristan , Orr Rhonda 
Published: May 2017

Context: Rugby union is a physically demanding collision sport with high injury rates. There is a common perception that higher training loads result in greater injury risk in field-based sports. Objectives: To determine injury, anthropometric, and physical-performance characteristics in junior rugby union players and investigate the interaction between training load and injury across a competitive season. Design: Prospective cohort study. Methods: Fifty-one players (age 19.2 ± 0.7 y) from an under-20 university rugby union team (forwards, n = 27; backs, n = 24) participated in a study conducted over a competition season. Training load, injury characteristics, anthropometry, physiological performance, and match time-loss injury incidence were observed. Results: Backs had significantly lower body mass (ES [95% CI] = 1.6 [0.9, 2.2]), skinfold thickness (ES = 1.1 [0.5, 1.7]), strength (squat ES = 0.6 [0.0, 1.2], deadlift ES = 0.6 [0.0, 1.1], bench press ES = 0.9 [0.4, 1.5]), lower-body power (ES = 0.4 [−0.2, 1.0]), and higher maximal aerobic capacity (ES = −0.3 [−0.8, 0.3]) than forwards. Match injury incidence was 107.3 injuries/1000 player hours (forwards 91.4/1000, backs 125.5/1000) during preseason and 110.7 injuries/1000 player hours (forwards 124.1/1000, backs 95.2/1000) during in-season. Forwards showed higher incidence of joint and ligament (P = .049) and upper-limb (P = .011) injuries than backs. No significant relationship between overall training load and match injury incidence was found. However, lower match injury incidence was associated with higher weekly training volume in backs (P = .007). Conclusions: Positional differences in body composition, performance, injury characteristics, and match injury patterns were identified in junior university rugby union players, indicating the need for position-specific training programs to reduce risk of injury.
Preservice Physical Education Teachers’ Service Learning Experiences Related to Comprehensive School Physical Activity Programming
Authors: Webster Collin A. , Nesbitt Danielle , Lee Heesu , Egan Cate 
Published: May 2017

Purpose:The purpose of this study was to examine preservice physical education teachers’ (PPET) service learning experiences planning and implementing course assignments aligned with comprehensive school physical activity program (CSPAP) recommendations.Methods:Based on service learning principles, PPETs (N = 18) enrolled in a physical education methods class planned, implemented, and reflected on physical activity promotion events before, during, and after school for youth, staff, and parents. Data sources included focus group interviews, written reflections, field notes, and artifacts. Constant comparison techniques and triangulation guided data analysis and interpretation to identify overarching themes describing the PPETs’ successes, challenges, and lessons learned.Results:Four themes were identified: (a) outcomes with youth, parents, and staff, (b) communication, (c) planning and preparation, and (d) priorities and possibilities.Discussion/Conclusion:This study provides insight into the feasibility and outcomes of CSPAP-related service learning for PPETs, and uncovers promising aspects as well as potential issues with CSPAP implementation.
Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response
Authors: Larimer Benjamin M. , Wehrenberg-Klee Eric , Dubois Frank , Mehta Anila , Kalomeris Taylor , Flaherty Keith , Boland Genevieve , Mahmood Umar 
Published: May 2017

Abstract
While cancer immunotherapy can produce dramatic responses, only a minority of patients respond to treatment. Reliable response biomarkers are needed to identify responders, and conventional imaging modalities have not proved adequate. Here, we provide a preclinical proof of concept for the use of granzyme B, a downstream effector of tumoral cytotoxic T cells, as an early biomarker for tumors responding to immunotherapy. We designed novel PET imaging probes for the murine and human granzyme B isoforms that specifically and quantitatively bind granzyme B. Immunotherapy-treated mice were imaged prior to therapy-induced tumor volume reduction. Imaging distinguished treated responders from nonresponders with excellent predictive ability. To assess the clinical value of a granzyme B imaging paradigm, biopsy specimens from melanoma patients on checkpoint inhibitor therapy were analyzed. A marked differential in granzyme B expression was observed between treated responders and nonresponders. Additionally, our human probe was able to specifically detect granzyme B expression in human samples, providing a clear candidate for clinical application. Overall, our results suggest granzyme B PET imaging can serve as a quantitatively useful predictive biomarker for efficacious responses to cancer immunotherapy. Cancer Res; 77(9); 2318–27. ©2017 AACR.
Favorable Cardiovascular Health, Compression of Morbidity, and Healthcare Costs
Authors: Allen Norrina B. , Zhao Lihui , Liu Lei , Daviglus Martha , Liu Kiang , Fries James , Shih Ya-Chen Tina , Garside Daniel , Vu Thanh-Huyen , Stamler Jeremiah , Lloyd-Jones Donald M. 
Published: May 2017

Background:
We examined the association of cardiovascular health at younger ages with the proportion of life lived free of morbidity, the cumulative burden of morbidity, and average healthcare costs at older ages.

Methods:

The CHA study (Chicago Heart Association Detection Project in Industry) is a longitudinal cohort of employed men and women 18 to 74 years of age at baseline examination in 1967 to 1973. Baseline measurements included blood pressure, cholesterol, diabetes mellitus, body mass index, and smoking. Individuals were classified into 1 of 4 strata of cardiovascular health: favorable levels of all factors, 0 factors high but ≥1 elevated risk factors, 1 high risk factor, and ≥2 high risk factors. Linked Medicare and National Death Index data from 1984 to 2010 were used to determine morbidity in older age. An individual’s all-cause morbidity score and cardiovascular morbidity score were calculated from
International Classification of Disease, Ninth Revision
codes for each year of follow-up.

Results:

We included 25 804 participants who became ≥65 years of age by 2010, representing 65% of all original CHA participants (43% female; 90% white; mean age, 44 years at baseline); 6% had favorable levels of all factors, 19% had ≥1 risk factors at elevated levels, 40% had 1 high risk factor, and 35% had ≥2 high risk factors. Favorable cardiovascular health at younger ages extended survival by almost 4 years and postponed the onset of all-cause and cardiovascular morbidity by 4.5 and 7 years, respectively, resulting in compression of morbidity in both absolute and relative terms. This translated to lower cumulative and annual healthcare costs for those in favorable cardiovascular health (
P
<0.001) during Medicare eligibility.

Conclusions:
Individuals in favorable cardiovascular health in early middle age live a longer, healthier life free of all types of morbidity. These findings provide strong support for prevention efforts earlier in life aimed at preserving cardiovascular health and reducing the burden of disease in older ages.
Sea Surface Scanner (S3): A Catamaran for High-Resolution Measurements of Biogeochemical Properties of the Sea Surface Microlayer
Authors: Ribas-Ribas Mariana , Hamizah Mustaffa Nur Ili , Rahlff Janina , Stolle Christian , Wurl Oliver 
Published: May 2017

AbstractThis paper describes a state-of-the-art research catamaran to investigate processes such as air–sea gas exchange, heat exchange, surface blooms, and photochemistry at the sea surface microlayer (SML) with high-resolution measurements of 0.1-Hz frequency. As the boundary layer between the ocean and the atmosphere, the SML covers 70% of Earth. The remote-controlled Sea Surface Scanner is based on a glass disk sampler to automate the sampling of the thin SML, overcoming the disadvantages of techniques such as low volume sampling and ex situ measurement of the SML. A suite of in situ sensors for seven biogeochemical parameters (temperature, pH, dissolved oxygen, salinity, chromophoric dissolved organic matter, chlorophyll-a, and photosynthetic efficiency) was implemented to characterize the SML in reference to the mixed bulk water. The Sea Surface Scanner has the capability to collect 24 discrete water samples with a volume of 1 L each for further laboratory analysis. Meteorological parameters such as wind speed influence SML properties and are continuously monitored. This paper reports the use of the Sea Surface Scanner to identify and study (i) upwelling regions and associated fronts, (ii) rain events, and (iii) the occurrence of surface blooms. The high patchiness of the SML was detected during the observed sea surface phenomena, and high-resolution mapping of the biogeochemical parameters of the oceanic boundary layer to the atmosphere are presented for the first time. The Sea Surface Scanner is a new technology to map and understand sea surface processes and, ultimately, to fill the gaps in knowledge about ocean–atmosphere interactions relevant to ocean and climate science.
Embedding an enriched environment in an acute stroke unit increases activity in people with stroke: a controlled before–after pilot study
Authors: Rosbergen Ingrid CM , Grimley Rohan S , Hayward Kathryn S , Walker Katrina C , Rowley Donna , Campbell Alana M , McGufficke Suzanne , Robertson Samantha T , Trinder Janelle , Janssen Heidi , Brauer Sandra G 
Published: May 2017

Objectives: To determine whether an enriched environment embedded in an acute stroke unit could increase activity levels in acute stroke patients and reduce adverse events. Design: Controlled before–after pilot study. Setting: An acute stroke unit in a regional Australian hospital. Participants: Acute stroke patients admitted during (a) initial usual care control period, (b) an enriched environment period and (c) a sustainability period. Intervention: Usual care participants received usual one-on-one allied health intervention and nursing care. The enriched environment participants were provided stimulating resources, communal areas for eating and socializing and daily group activities. Change management strategies were used to implement an enriched environment within existing staffing levels. Main Measures: Behavioural mapping was used to estimate patient activity levels across groups. Participants were observed every 10 minutes between 7.30 am and 7.30 pm within the first 10 days after stroke. Adverse and serious adverse events were recorded using a clinical registry. Results: The enriched environment group ( n = 30, mean age 76.7 ± 12.1) spent a significantly higher proportion of their day engaged in ‘any’ activity (71% vs. 58%, P = 0.005) compared to the usual care group ( n = 30, mean age 76.0 ± 12.8). They were more active in physical (33% vs. 22%, P < 0.001), social (40% vs. 29%, P = 0.007) and cognitive domains (59% vs. 45%, P = 0.002) and changes were sustained six months post implementation. The enriched group experienced significantly fewer adverse events (0.4 ± 0.7 vs.1.3 ± 1.6, P = 0.001), with no differences found in serious adverse events (0.5 ± 1.6 vs.1.0 ± 2.0, P = 0.309). Conclusions: Embedding an enriched environment in an acute stroke unit increased activity in stroke patients.
Manipulation of Foot Strike and Footwear Increases Achilles Tendon Loading During Running
Authors: Rice Hannah , Patel Mubarak 
Published: May 2017

Background: The Achilles tendon is the most common site of tendon overuse injury in humans. Running with a forefoot strike pattern and in minimal shoes is a topic of recent interest, yet evidence is currently limited regarding the combined influence of foot strike and footwear on Achilles tendon loading. Purpose: To investigate the influence of both foot strike and footwear on Achilles tendon loading in habitual rearfoot strike runners. Study Design: Controlled laboratory study. Methods: Synchronized kinematic and force data were collected from 22 habitual rearfoot strikers (11 male), who habitually ran in nonminimal running shoes, during overground running at 3.6 m·s-1. Participants ran in 3 different footwear conditions (standard running shoe, minimal running shoe, and barefoot) with both a rearfoot strike (RFS) and an imposed forefoot strike (FFS) in each footwear condition. Achilles tendon loading was estimated by use of inverse dynamics, where the Achilles tendon moment arm was determined with a regression equation. A 2-way, repeated-measures analysis of variance was used to compare conditions. Results: Achilles tendon impulse was greater when subjects ran with an FFS rather than an RFS in minimal shoes. Achilles tendon loading rates were higher when subjects ran either in minimal shoes or barefoot than in standard shoes, regardless of foot strike. Conclusion: In runners who habitually rearfoot strike in standard running shoes, running in minimal shoes or barefoot increased the rate of tendon loading, and running with a forefoot strike in minimal shoes increased the magnitude of tendon loading. Clinical Relevance: Transitioning to these running conditions may increase the risk of tendinopathy.
Two journeys: Forces that unite and disperse a community in the homeland
Authors: MacNeill Richard J 
Published: May 2017

This article uses ‘the journey’ – the act of traversing a physical landscape – as a means of understanding the role landscape can play in preserving and reinforcing societies and their activities. It is based on material recorded over the course of three field seasons between 2006 and 2014 in the landscape of the Karavas basin in the northern part of Kythera, an island off the southern tip of the Greek Peloponnese. This material consists of spatial records of the location and the character of gardens, water channels, mills and other features in addition to accounts and reminiscences of inhabitants that relate to the former and current use of the landscape and their social, cultural and spiritual relationships to it. In this article, the journey is used to reconstruct a cultural landscape, a dynamic and self-sustaining amalgam of cultural, social and physical mechanisms and features. In this reconstruction, observed relationships between the inhabitants and their infrastructure form the basis for two interpretive approaches. The first considers the landscape and community as a unity, within which the character of the one is dependent on and reflects the character of the other. The second approaches the community as an interlocking and self-sustaining collection of cognitive and behavioural mechanisms. In this exploratory reconstruction, these two approaches are regarded as complementary, each compensating for conceptual and logical shortcomings of the other. The essential link between these two approaches is the landscape and its multiple meanings, in one sense a world defined, moulded and mediated by the task; in another, a structure of culturally mediated mechanisms. The author argues that both post-structural and structural interpretations generate valid and complementary understandings.