bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modelling the spatial distribution of Fasciola hepatica in bovines using decision tree, logistic regression and GIS query approaches for Brazil
Authors: BENNEMA S. C. , MOLENTO M. B. , SCHOLTE R. G. , CARVALHO O. S. , PRITSCH I. 
Published: August 2017

SUMMARYFascioliasis is a condition caused by the trematode Fasciola hepatica. In this paper, the spatial distribution of F. hepatica in bovines in Brazil was modelled using a decision tree approach and a logistic regression, combined with a geographic information system (GIS) query. In the decision tree and the logistic model, isothermality had the strongest influence on disease prevalence. Also, the 50-year average precipitation in the warmest quarter of the year was included as a risk factor, having a negative influence on the parasite prevalence. The risk maps developed using both techniques, showed a predicted higher prevalence mainly in the South of Brazil. The prediction performance seemed to be high, but both techniques failed to reach a high accuracy in predicting the medium and high prevalence classes to the entire country. The GIS query map, based on the range of isothermality, minimum temperature of coldest month, precipitation of warmest quarter of the year, altitude and the average dailyland surface temperature, showed a possibility of presence of F. hepatica in a very large area. The risk maps produced using these methods can be used to focus activities of animal and public health programmes, even on non-evaluated F. hepatica areas.
Existence and properties of semi-bounded global solutions to the functional differential equation with Volterra-type operators on the real line
Authors: Aguerrea Maitere , Hakl Robert 
Published: August 2017

Consider the equationwhere are linear positive continuous operators and f : Cloc(ℝ;ℝ) → Lloc(ℝ;ℝ) is a continuous operator satisfying the local Carathéodory conditions. Efficient conditions guaranteeing the existence of a global solution, which is bounded and non-negative in the neighbourhood of –∞, to the equation considered are established provided that ℓ0, ℓ1 and f are Volterra-type operators. The existence of a solution that is positive on the whole real line is discussed as well. Furthermore, the asymptotic properties of such solutions are studied in the neighbourhood of –∞. The results are applied to certain models appearing in the natural sciences.
Erratum For ‘A Bound on the Number of Edges in Graphs Without an Even Cycle’
Authors: BUKH BORIS , JIANG ZILIN 
Published: August 2017

Due to a calculation error, the constant in the main theorem is not $80 \sqrt{k\log k}$ but $80\sqrt{k} \log k$. The error was discovered by Xizhi Liu.For a new discussion on the limit of the method used in this paper see the revised arXiv version of the paper.
SLAVES, GLADIATORS, AND DEATH: KANTIAN LIBERALISM AND THE MORAL LIMITS OF CONSENT
Authors: Ramsay Marc 
Published: August 2017

ABSTRACTIrving Kristol invoked the example of voluntary gladiatorial contests to show that liberalism's commitment to personal autonomy cannot override majoritarian standards of morality. Liberalism cannot explain why voluntary gladiatorial contests should be banned, but liberals know that such contests should be banned. Thus, honest liberals must concede that majoritarian morality trumps consent. Arthur Ripstein argues that the consent in gladiatorial agreements contains a formal defect. According to Ripstein, because both gladiators sanction their own deaths, both reduce themselves to the status of mere things or slaves. On the Kantian view, slavery contracts undermine the personal sovereignty that binding contracts must presuppose, so Kantian liberals can reject gladiatorial contracts and still avoid legal moralism. I argue that while Kantian liberals have cogent internal reasons for rejecting slavery contracts, not all gruesome and deadly contests are matters of slavery. Thus, Kristol's challenge remains intact.
Somali, Latino and Hmong parents’ perceptions and approaches about raising healthy-weight children: a community-based participatory research study
Authors: Arcan Chrisa , Culhane-Pera Kathleen A , Pergament Shannon , Rosas-Lee Maira , Xiong Mai Bao 
Published: August 2017

AbstractObjectiveImmigrants in the USA are confronted with health disparities, including childhood obesity and obesity-related chronic diseases. We aimed to identify perceptions of childhood body weight, approaches to raising healthy children and desires for supportive programmes of Somali, Latino and Hmong (SLM) parents in the Twin Cities, Minnesota, USA.DesignUsing community-based participatory research, ten focus groups (FG) were conducted with sixty-seven parents (n 28 Somali, three FG; n 19 Latino, four FG; n 20 Hmong, three FG) of 3–12-year-old children in their native language. Demographic information was collected.ResultsSLM parents perceived that health is not necessarily weight-based; childhood obesity is caused by overeating, eating unhealthy foods and sedentary activities; traditional foods are generally healthy while American foods are generally unhealthy; and healthy children are inherently physically active. Parents identified their goals as feeding children so they would be healthy and happy, helping them be active and safe, and teaching them to cook traditional foods to be self-sufficient and maintain their cultural identity. Parents were challenged by children’s unhealthy food and sedentary preferences, their own uncertainties about healthy foods and behaviours, and structural factors. Parents thought interventions could help them with these challenges, including information about healthy foods, age-appropriate portion sizes, safe places to be active and strategies tailored to their cultural norms.ConclusionsSLM parents are trying to raise healthy-weight children based on their understanding of children’s health, weight, diet and physical activity, while dealing with social, economic and environmental challenges and trying to maintain cultural identity and traditions.
Associations of Baltic Sea and Mediterranean dietary patterns with bone mineral density in elderly women
Authors: Erkkilä Arja T , Sadeghi Homa , Isanejad Masoud , Mursu Jaakko , Tuppurainen Marjo , Kröger Heikki 
Published: August 2017

AbstractObjectiveDietary quality in relation to bone health has been analysed in relatively few studies. The current study aimed to assess the association of the Baltic Sea diet (BSD) and the Mediterranean diet (MD) with bone mineral density (BMD) among elderly women.DesignLumbar, femoral and total body BMD were measured by dual-energy X-ray absorptiometry at baseline and year 3. Dietary intake was measured by 3 d food record at baseline. BSD and MD scores were calculated from food and alcohol consumption and nutrient intake. Information on lifestyle, diseases and medications was collected by questionnaires. Longitudinal associations of BSD and MD scores with BMD were analysed using linear mixed models.SettingInterventional prospective Kuopio Osteoporosis Risk Factor and Fracture Prevention study including women aged 65–71 years and residing in Kuopio province, Finland.SubjectsWomen (n554) with mean age of 67·9 (sd1·9) years and mean BMI of 28·8 (sd4·7) kg/m2.ResultsHigher BSD scores were associated with higher intakes of fruit and berries, vegetables, fish and low-fat dairy products, and lower intake of sausage. Higher MD scores were associated with higher consumption of fruit and berries and vegetables. BSD and MD scores were associated with higher PUFA:SFA and higher fibre intake. Femoral, lumbar or total body BMD was not significantly different among the quartiles of BSD or MD score.ConclusionThe lack of associations suggest that Baltic Sea and Mediterranean dietary patterns may not adequately reflect dietary factors relevant to bone health.
Adapting the standardised computer- and interview-based 24 h dietary recall method (GloboDiet) for dietary monitoring in Latin America
Authors: Bel-Serrat Silvia , Knaze Viktoria , Nicolas Genevieve , Marchioni Dirce M , Steluti Josiane , Mendes Aline , Crispim Sandra P , Fisberg Regina M , Pereira Rosangela A , Araujo Marina C , Sichieri Rosely , Yokoo Edna M , Sánchez-Pimienta Tania , Aburto Tania C , Pedraza Lilia S , Slimani Nadia 
Published: August 2017

AbstractObjectiveThe present study describes the procedure and approaches needed to adapt and harmonise the GloboDiet methodology, a computer- and interview-based 24 h dietary recall, for use in two Latin American pilot countries, Brazil and Mexico.DesignAbout seventy common and country-specific databases on foods, recipes, dietary supplements, quantification methods and coefficients were customised and translated following standardised guidelines, starting from existing Spanish and Portuguese versions.SettingBrazil and Mexico.SubjectsNot applicable.ResultsNew subgroups were added into the existing common food classification together with new descriptors required to better classify and describe specific Brazilian and Mexican foods. Quantification methods were critically evaluated and adapted considering types and quantities of food consumed in these two countries, using data available from previous surveys. Furthermore, the photos to be used for quantification purposes were identified for compilation in country-specific but standardised picture booklets.ConclusionsThe completion of the customisation of the GloboDiet Latin America versions in these two pilot countries provides new insights into the adaptability of this dietary international tool to the Latin American context. The ultimate purpose is to enable dietary intake comparisons within and between Latin American countries, support building capacities and foster regional and international collaborations. The development of the GloboDiet methodology could represent a major benefit for Latin America in terms of standardised dietary methodologies for multiple surveillance, research and prevention purposes.
Interspecies nutrient extraction and toxin delivery between bacteria
Authors: Stempler Ofer , Baidya Amit K. , Bhattacharya Saurabh , Malli Mohan Ganesh Babu , Tzipilevich Elhanan , Sinai Lior , Mamou Gideon , Ben-Yehuda Sigal 
Published: August 2017

AbstractBacteria have developed various mechanisms by which they sense, interact, and kill other bacteria, in an attempt to outcompete one another and survive. Here we show that Bacillus subtilis can kill and prey on Bacillus megaterium. We find that Bacillus subtilis rapidly inhibits Bacillus megaterium growth by delivering the tRNase toxin WapA. Furthermore, utilizing the methionine analogue L-azidohomoalanine as a nutrient reporter, we provide evidence of nutrient extraction from Bacillus megaterium by Bacillus subtilis. Toxin delivery and nutrient extraction occur in a contact-dependent manner, and both activities are abolished in the absence of the phosphodiestrase YmdB, shown previously to mediate intercellular nanotube formation. Furthermore, we detect the localization of WapA molecules to nanotubes. Thus, we propose that Bacillus subtilis utilizes the same nanotube apparatus in a bidirectional manner, delivering toxin and acquiring beneficial cargo, thereby maximally exploiting potential niche resources.
BRCA locus-specific loss of heterozygosity in germline BRCA1 and BRCA2 carriers
Authors: Maxwell Kara N. , Wubbenhorst Bradley , Wenz Brandon M. , De Sloover Daniel , Pluta John , Emery Lyndsey , Barrett Amanda , Kraya Adam A. , Anastopoulos Ioannis N. , Yu Shun , Jiang Yuchao , Chen Hao , Zhang Nancy R. , Hackman Nicole , D’Andrea Kurt , Daber Robert , Morrissette Jennifer J. D. , Mitra Nandita , Feldman Michael , Domchek Susan M. , Nathanson Katherine L. 
Published: August 2017

AbstractComplete loss of BRCA1 or BRCA2 function is associated with sensitivity to DNA damaging agents. However, not allBRCA1andBRCA2germline mutation-associated tumors respond. Herein we report analyses of 160BRCA1andBRCA2germline mutation-associated breast and ovarian tumors. Retention of the normalBRCA1orBRCA2allele (absence of locus-specific loss of heterozygosity (LOH)) is observed in 7% ofBRCA1ovarian, 16% ofBRCA2ovarian, 10% ofBRCA1breast, and 46% ofBRCA2breast tumors. These tumors have equivalent homologous recombination deficiency scores to sporadic tumors, significantly lower than scores in tumors with locus-specific LOH (ovarian,P = 0.0004; breastP < 0.0001, two-tailed Student’st-test). Absence of locus-specific LOH is associated with decreased overall survival in ovarian cancer patients treated with platinum chemotherapy (P = 0.01, log-rank test). Locus-specific LOH may be a clinically useful biomarker to predict primary resistance to DNA damaging agents in patients with germlineBRCA1andBRCA2mutations.
Androgen receptor as a mediator and biomarker of radioresistance in triple-negative breast cancer
Authors: Speers Corey , Zhao Shuang G. , Chandler Ben , Liu Meilan , Wilder-Romans Kari , Olsen Eric , Nyati Shyam , Ritter Cassandra , Alluri Prasanna G. , Kothari Vishal , Hayes Daniel F. , Lawrence Theodore S. , Spratt Daniel E. , Wahl Daniel R. , Pierce Lori J. , Feng Felix Y. 
Published: August 2017

AbstractIncreased rates of locoregional recurrence have been observed in triple-negative breast cancer despite chemotherapy and radiation therapy. Thus, approaches that combine therapies for radiosensitization in triple-negative breast cancer are critically needed. We characterized the radiation therapy response of 21 breast cancer cell lines and paired this radiation response data with high-throughput drug screen data to identify androgen receptor as a top target for radiosensitization. Our radiosensitizer screen nominated bicalutamide as the drug most effective in treating radiation therapy-resistant breast cancer cell lines. We subsequently evaluated the expression of androgen receptor in >2100 human breast tumor samples and 51 breast cancer cell lines and found significant heterogeneity in androgen receptor expression with enrichment at the protein and RNA level in triple-negative breast cancer. There was a strong correlation between androgen receptor RNA and protein expression across all breast cancer subtypes (R2 = 0.72, p < 0.01). In patients with triple-negative breast cancer, expression of androgen receptor above the median was associated with increased risk of locoregional recurrence after radiation therapy (hazard ratio for locoregional recurrence 2.9–3.2)) in two independent data sets, but there was no difference in locoregional recurrence in triple-negative breast cancer patients not treated with radiation therapy when stratified by androgen receptor expression. In multivariable analysis, androgen receptor expression was most significantly associated with worse local recurrence-free survival after radiation therapy (hazard ratio of 3.58) suggesting that androgen receptor expression may be a biomarker of radiation response in triple-negative breast cancer. Inhibition of androgen receptor with MDV3100 (enzalutamide) induced radiation sensitivity (enhancement ratios of 1.22–1.60) in androgen receptor-positive triple-negative breast cancer lines, but did not affect androgen receptor-negative triple-negative breast cancer or estrogen-receptor-positive, androgen receptor-negative breast cancer cell lines. androgen receptor inhibition with MDV3100 significantly radiosensitized triple-negative breast cancer xenografts in mouse models and markedly delayed tumor doubling/tripling time and tumor weight. Radiosensitization was at least partially dependent on impaired dsDNA break repair mediated by DNA protein kinase catalytic subunit. Our results implicate androgen receptor as a mediator of radioresistance in breast cancer and identify androgen receptor inhibition as a potentially effective strategy for the treatment of androgen receptor-positive radioresistant tumors.
Emergent magnetic anisotropy in the cubic heavy-fermion metal CeIn3
Authors: Moll Philip J. W. , Helm Toni , Zhang Shang-Shun , Batista Cristian D. , Harrison Neil , McDonald Ross D. , Winter Laurel E. , Ramshaw B. J. , Chan Mun K. , Balakirev Fedor F. , Batlogg Bertram , Bauer Eric D. , Ronning Filip 
Published: August 2017

AbstractMetals containing cerium exhibit a diverse range of fascinating phenomena including heavy fermion behavior, quantum criticality, and novel states of matter such as unconventional superconductivity. The cubic system CeIn3has attracted significant attention as a structurally isotropic Kondo lattice material possessing the minimum required complexity to still reveal this rich physics. By using magnetic fields with strengths comparable to the crystal field energy scale, we illustrate a strong field-induced anisotropy as a consequence of non-spherically symmetric spin interactions in the prototypical heavy fermion material CeIn3. This work demonstrates the importance of magnetic anisotropy in modelingf-electron materials when the orbital character of the 4fwavefunction changes (e.g., with pressure or composition). In addition, magnetic fields are shown to tune the effective hybridization and exchange interactions potentially leading to new exotic field tuned effects inf-based materials.
Habituation as an adaptive shift in response strategy mediated by neuropeptides
Authors: Ardiel Evan L. , Yu Alex J. , Giles Andrew C. , Rankin Catharine H. 
Published: August 2017

AbstractHabituation is a non-associative form of learning characterized by a decremented response to repeated stimulation. It is typically framed as a process of selective attention, allowing animals to ignore irrelevant stimuli in order to free up limited cognitive resources. However, habituation can also occur to threatening and toxic stimuli, suggesting that habituation may serve other functions. Here we took advantage of a high-throughput Caenorhabditis elegans learning assay to investigate habituation to noxious stimuli. Using real-time computer vision software for automated behavioral tracking and optogenetics for controlled activation of a polymodal nociceptor, ASH, we found that neuropeptides mediated habituation and performed an RNAi screen to identify candidate receptors. Through subsequent mutant analysis and cell-type-specific gene expression, we found that pigment-dispersing factor (PDF) neuropeptides function redundantly to promote habituation via PDFR-1-mediated cAMP signaling in both neurons and muscles. Behavioral analysis during learning acquisition suggests that response habituation and sensitization of locomotion are parts of a shifting behavioral strategy orchestrated by pigment dispersing factor signaling to promote dispersal away from repeated aversive stimuli.
Invasive trophoblast promote stromal fibroblast decidualization via Profilin 1 and ALOX5
Authors: Menkhorst E. M. , Van Sinderen M. L. , Rainczuk K. , Cuman C. , Winship A. , Dimitriadis E. 
Published: August 2017

AbstractDuring the establishment of pregnancy, extravillous trophoblast (EVT) must invade into the uterine decidua to facilitate decidual artery remodelling to create the placental blood supply. The local decidual environment is thought to regulate trophoblast invasion, however these interactions are poorly defined in humans. Recent evidence in women suggests impaired decidualization is associated with miscarriage and preeclampsia. Primary human endometrial stromal cells (HESC) and first trimester extravillous trophoblast (EVTs) were used to assess the effect of EVT-secreted factors on HESC decidualization, adhesion, proliferation and migration. We determined the role of profilin (PFN)1, an EVT-secreted factor, on HESC function and identified a downstream target of PFN1. EVT-secreted factors induced HESC decidualization and enhanced decidualized HESC adhesion, proliferation and migration. Recombinant PFN1 enhanced methoxyprogesterone acetate-induced HESC decidualization and proliferation. PFN1 down-regulated the expression of lipoxygenase arachidonate 5-lipoxygenase (ALOX5) in HESC and THP-1 macrophages. ALOX5 localised to decidual cells and CD68+macrophages in 1st trimester decidua. This study demonstrated that EVT secretions, including PFN1, enhanced HESC decidualization and motility. This study has identified a new pathway that facilitates appropriate decidualization during the establishment of pregnancy.
Nonlinear Bayesian filtering and learning: a neuronal dynamics for perception
Authors: Kutschireiter Anna , Surace Simone Carlo , Sprekeler Henning , Pfister Jean-Pascal 
Published: August 2017

AbstractThe robust estimation of dynamical hidden features, such as the position of prey, based on sensory inputs is one of the hallmarks of perception. This dynamical estimation can be rigorously formulated by nonlinear Bayesian filtering theory. Recent experimental and behavioral studies have shown that animals’ performance in many tasks is consistent with such a Bayesian statistical interpretation. However, it is presently unclear how a nonlinear Bayesian filter can be efficiently implemented in a network of neurons that satisfies some minimum constraints of biological plausibility. Here, we propose the Neural Particle Filter (NPF), a sampling-based nonlinear Bayesian filter, which does not rely on importance weights. We show that this filter can be interpreted as the neuronal dynamics of a recurrently connected rate-based neural network receiving feed-forward input from sensory neurons. Further, it captures properties of temporal and multi-sensory integration that are crucial for perception, and it allows for online parameter learning with a maximum likelihood approach. The NPF holds the promise to avoid the ‘curse of dimensionality’, and we demonstrate numerically its capability to outperform weighted particle filters in higher dimensions and when the number of particles is limited.
High energy storage density over a broad temperature range in sodium bismuth titanate-based lead-free ceramics
Authors: Yang Haibo , Yan Fei , Lin Ying , Wang Tong , Wang Fen 
Published: August 2017

AbstractA series of (1-x)Bi0.48La0.02Na0.48Li0.02Ti0.98Zr0.02O3-xNa0.73Bi0.09NbO3 ((1-x)LLBNTZ-xNBN) (x = 0-0.14) ceramics were designed and fabricated using the conventional solid-state sintering method. The phase structure, microstructure, dielectric, ferroelectric and energy storage properties of the ceramics were systematically investigated. The results indicate that the addition of Na0.73Bi0.09NbO3 (NBN) could decrease the remnant polarization (P
r
) and improve the temperature stability of dielectric constant obviously. The working temperature range satisfying TCC150 °C ≤±15% of this work spans over 400 °C with the compositions of x ≥ 0.06. The maximum energy storage density can be obtained for the sample with x = 0.10 at room temperature, with an energy storage density of 2.04 J/cm3 at 178 kV/cm. In addition, the (1-x)LLBNTZ-xNBN ceramics exhibit excellent energy storage properties over a wide temperature range from room temperature to 90 °C. The values of energy storage density and energy storage efficiency is 0.91 J/cm3 and 79.51%, respectively, for the 0.90LLBNTZ-0.10NBN ceramic at the condition of 100 kV/cm and 90 °C. It can be concluded that the (1-x)LLBNTZ-xNBN ceramics are promising lead-free candidate materials for energy storage devices over a broad temperature range.