bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drilling Fluid Optimization at M Fields: How to Deal with the Total Loss in Globigerina Limestone Reservoir
Authors: Fajarrenaningtyas Ursula , Xiaopo Liu , Zhi Yang , Athallah Fairuz , Zulkarnain Shubhan , Sinaga Samuel Zulkhifly 
Published: October 2024

Abstract
A vision to become the largest gas producer in East Java – Indonesia, has led Husky-CNOOC Madura Limited (HCML) to increase its gas production by developing high-gas wells at M Fields. In December 2021, HCML commenced the M Fields development drilling campaign. Ten (10) development wells in three (3) fields were drilled and completed by March 2023. During the campaign, HCML used water-based mud (WBM) to drill all sections, including the reservoir section. The reservoir section is thin-highly porous Globigerina (GL) Limestone. This reservoir was characterized by Globigerina foraminifera abundance with excellence which has an average net-to-gross (NTG) of 95%, average porosity of 33-49%, and average permeability of 5-225 mD. Critical challenges were encountered due to limited available data on offset exploration wells leading to uncertainties in the simulation model and drilling design.
Total loss circulation occurred while drilling the reservoir section of the first development well leading to the earlier setting of the well target depth (TD). Upon the total loss occurrence, critical actions were taken directly in a relatively short time, including the re-assessment of wellbore stability, reservoir properties, and fluid gradient and then followed up by optimization of the drilling fluid system and properties and application of optimized drilling parameters.
This paper presents successful strategic actions to drill reservoir section in M Fields wells after encountering massive total loss circulation in the first field. These actions resulted in a technically feasible, economically viable, and reservoir-friendly system with adjustable mud weight (MW) and an optimized drilling operations plan and procedure. Ultimately, this process helped to drill the subsequent development wells safely and economically to TD leading to a successful M Fields development drilling campaign.
Multiphase Characterization of Waxy Crude Oil and its Impact to Optimize Flow Assurance Mitigation for Operation and Field Development
Authors: Sariman Mior Zaiga , Saaid Ismail M , Jasamai Mazuin , Bhaskoro Petrus Tri 
Published: October 2024

Waxy crude oils are crude oils that contain high paraffins content. The paraffins can be of wide range of high molecular weight straight chain, normal paraffin and branched or cyclic paraffin [3]. Flow Assurance issues normally associated with waxy crude oil are wax deposition and wax gelation. Wax deposition is when solid wax crystals precipitate on the colder surfaces of the wall of pipeline, as the temperature drops below the wax appearance temperature. With respect to wax gelation, as the temperature drops lower than the wax appearance temperature, the paraffins will further crystallize [4]. The crystal-crystal interactions and interlocking effects will cause increase in viscosity, leading to ultimately the gelation and solidification of the crude oil [3].
Flows from production wells are in multiphase form. Produced water and associated gas are among the common phases that are produced in every production wells. The separation and stabilization to its individual phase normally conducted at the central production platform, or further downstream at onshore terminal for field with long tie back. The presence of water and gas in the production fluid has an influence on the severity of the waxy crude oil properties. Addition of gas lift, gas injection, water injection, EOR fluid in the field can also have an influence on the fluid properties and phases [4].
Management of waxy crude oil especially in the area of wax gelation had always been conservative. The practice in design and operation normally allocated high margin of uncertainties to totally avoid the wax related flow assurance issues. Based on industrial experience, it is common to develop a field with waxy crude oil flow assurance issues only by referring to its single phase stabilized crude oil properties. It is not common for the multiphase properties, and the influence of the different phases to be included in the design basis. This can lead to over conservatism in curating the flow assurance strategy affecting the economic of the venture. Additionally, new technologies like remote monitoring and machine learning, as well as concerns like impact to green house gas emissions are seldom considered.
Prediction of Waxy Crude Oil Properties Using Near- Infrared Spectroscopy for Upstream Applications
Authors: Wazir N. Ahmad , Saadon S. , Bashkoro P. Tri , Dolmat N. , Othman A. , Sariman M. 
Published: October 2024

Abstract
Monitoring the flowability of waxy crude oil in offshore pipelines is crucial due to its tendency to solidify when the ambient temperature drops below the crude oil's pour point. Preventing this condition is essential to avoid undesired clogging in the pipeline. Pour Point temperature (PPT) and density are among the critical flow assurance (FA) properties for waxy crude oil that directly indicate the flowability state and the quality of the waxy crude oil in the pipeline. Therefore, it is imperative to develop a rapid and precise technique for an in-situ determination of the waxy crude oil properties. This research describes the prediction of pour point and density of waxy crude oils by exploiting the absorbance spectrum obtained from near-infrared (NIR) region. In this study, the prediction of the PPT and density properties of waxy crude oils were investigated through a calibration models developed using Fourier transform near-infrared (FT-NIR) spectroscopy which capable of performing multicomponent analysis and can be used with multivariate analytic methods. The FT-NIR spectra for the waxy crude oil were captured and interpreted by using suitable spectra wavenumber regions through multivariate statistical techniques such as partial least square (PLS). A total of 110 samples of waxy crude oils were analyzed for their pour point and density using ASTM 64749-02 and ASTM D5002 methods, respectively. These properties were then utilized as reference data to establish the calibration models and validated using 40 unknown waxy crude oil samples to ensure the robustness of the models. The Calibration models developed for both properties had the coefficient of determination (R2) of 0.9895 with the RMSECV of 0.75% for the pour point and R2 of 0.9789 and RMSECV of 0.024% for the density property. The statistical evaluation of the validation samples also confirmed that the difference between the actual value and the predicted value from the calibration model was not significantly different and acceptable. Model validation exercise using unknown samples, successfully meeting model performance acceptance criteria of less than 20% outlier and less than 5%Relative standard deviation (RSD). Therefore, the both models have given a satisfactory result for the pour point and density properties determination using the FT-NIR technique. The results of this study indicated that FT-NIR spectroscopy with chemometrics and multivariate technique can be used for the pour point and density of the waxy crude oil monitoring to replace the time-consuming and labor-intensive conventional methods.
Evolution of Water-Gas Relative Permeability with Effective Stresses in Coal and Sandstone
Authors: Zhang Tiancheng , Li Jimmy Xuekai , Rudolph Victor , Chen Zhongwei 
Published: October 2024

Abstract
Relative permeability is an important parameter in reservoir engineering, playing a significant role in understanding and forecasting fluid flow behavior within rock formations. Relative permeability is affected by numerous factors, such as rock type, fluids wettability, pore size and fracture aperture, which was determined by effective stress and fracture stiffness that changes during the reservoir production. Nevertheless, when conducting reservoir simulation, it is a common practice to assume that relative permeability curves are fixed and do not vary with reservoir depletion, leading to substantial uncertainty in simulation outcomes. In this work, a suite of laboratory measurements was conducted to characterize the gas-water two-phase flow in coal and sandstone under varying confining stresses, and the results were then used to refine and update the existing relative permeability curves. Finally, this study conducted a comparative analysis of the two-phase flow curves in sandstone and coal, delving into the distinctions in the characteristics of two-phase flow within fractured porous media (coal) and non-fractured porous media (sandstone).
Our results show that as confining pressure increased, water mobility reduced, leading to its retention in the coal sample and resulting in a higher residual water saturation. These changes were reflected in a rightward shift in coal relative permeability curves. Additionally, the relative permeability of both water and gas increased with the increasing confining stress in the coal sample. In contrast, the sandstone sample showed only a slight increase in relative permeability with increasing confining stress, differing from the coal sample. Furthermore, the relative permeability of gas changed more obviously with water saturation when increasing confining stress for both coal and sandstone samples. The findings offer insights into the dynamic behaviour of permeability under varying effective stress conditions, enhancing our understanding of fluid flow in both coal and sandstone reservoir rocks.
Return to Work in Breast Cancer Patients With and Without Pre-Diagnosis Psychological Distress: A Prospective Cohort Study
Authors: Pai Tanmayi , Li Zhuo , McLaughlin Sarah , Pruthi Sandhya , Klassen Christine , Cornell Lauren 
Published: October 2024

Abstract

Purpose
Many women are employed at the time of breast cancer (BC) diagnosis. Pre-diagnosis psychological distress is prevalent among early-stage BC patients. We prospectively evaluated return to work (RTW) in BC patients with and without reported pre-diagnosis psychological distress over a 15-month period to determine if such distress affects workforce participation and mental health status after curative treatment.
Methods
188 patients with newly diagnosed stage 0-III BC and working 35-plus hours/week participated at Mayo Clinic in Minnesota and Florida. Patients received an email survey at diagnosis and 3 and 15 months later. Incidence of severe psychological distress (SPD) per the Kessler Psychological Distress Scale (K6, score ≥ 13) was assessed at each timepoint.
Results
77/188 survey respondents (41%) reported pre-diagnosis psychological distress, with 23.5% noting job-related stress. 59/188 patients (31%) had SPD at diagnosis, with similar incidence in the group that had pre-diagnosis distress (+ stress) and the non-stressed group (no-stress). The sample was highly educated and well salaried. The + stress group worked more hours on average at diagnosis (41.3 vs. 39.3 hours, p = 0.034). At 3 months, 83/141 respondents (60.1%) reported taking time off work after diagnosis, with 46.6% returning within 2 weeks and 42.5% requiring > 4 weeks’ break. More + stress patients reported RTW to maintain health insurance (13/56 vs. 6/85, p = 0.006), although this difference resolved by 15 months. SPD rates decreased over time but affected 17/104 respondents (16.3%) at 15 months.
Conclusion
Job-related stress is a primary driver of pre-diagnosis psychological distress. Three months after BC diagnosis, many women with pre-diagnosis psychological distress were motivated to RTW to keep employer-linked health insurance. SPD is prominent in BC patients; while SPD declined over time, it did not resolve completely.
Similarity of generalized trapezoidal fuzzy numbers with different left and right heights
Authors: Mengchuan Zhao , Deng Ke , Zhang Hua 
Published: October 2024

Abstract

Within the realm of fuzzy multicriteria decision-making, the measure of similarity in generalized trapezoidal fuzzy numbers (GTFNs) is vital for electing the most suitable option. Several studies focusing on similarity measures have been addressed in scholarly works. Nonetheless, the current methods lack adequate results for similarity calculations or fail to compute the differing left and right heights. The aim of this paper is to create a novel measure for assessing the similarity of GTFNs varying in their left and right heights. Initially, our analysis revealed that if both the left and right heights of a pair of GTFNs equal zero, their similarity is discernible solely through geometric distance. Conversely, if these heights differ from zero, we incorporated elements like center point distance, edge lengths, area, and both left and right heights into the similarity computation equation. The scope of this measure extends beyond GTFNs of varying left and right heights, encompassing the handling of random fuzzy numbers as well. Subsequently, certain properties of the suggested similarity measure are examined. Concentrates on ten properties, including translation, symmetry, folding, and the proportional increase and decrease in size. Furthermore, to confirm the new method's effectiveness, fifteen unique test sets are provided to evaluate the performance of three current techniques for determining similarity across various heights using the new approach.
The Impact of Paternity-Maternity Matching on Suicide Risk Among College Students: A Response Surface Analysis
Authors: zhan yuting 
Published: October 2024

Abstract

Purpose
The objective of this study is to investigate the impact of father-child and mother-child relationships on the suicide risk of college students.
Methods
A questionnaire survey was conducted on 1,215 college students using the Parent-Child Relationship Questionnaire, the Psychological Distress Questionnaire, and the Suicidal Behavior Questionnaire. Polynomial regression and response surface analyses were performed to analyze the data.
Results
The study found that college students had a lower suicide risk when there was consistent paternity and maternity, specifically in cases of “high paternity-high maternity” matching. However, when there was inconsistency, the effect of “low paternity-high maternal-children relationship” on the suicide risk of college students was not significant when matched with “high paternity-low maternal-children relationship”. The study found that psychological distress played a partial mediating role in the relationship between father-child relationship and college students’ suicide risk, and a full mediating role in the relationship between mother-child relationship and college students’ suicide risk.
Conclusion
The conclusion drawn was that similar levels of father-child and mother-child relationships significantly predicted the risk of suicide among college students.
Development and evaluation of RhizoQOL, a quality-of-life caregiver-reported survey for rhizomelic chondrodysplasia punctata, a rare peroxisomal disorder
Authors: Bose Mousumi , Anglade Tahra , Donlon Chelsea , Kerrihard Adrian , Berger Hila , Berkowitz Ariel , Ritchie Shawn , Smith Tara 
Published: October 2024

Abstract

Background
Rhizomelic chondrodysplasia punctata (RCDP) is a rare genetic disorder characterized by symptoms such as respiratory dysfunction, seizures, orthopedic issues, and neurodevelopmental delay. Potential therapeutics for RCDP warrant the development of clinical outcome assessments to assess the efficacy of treatment and the well-being of patients. Our study aimed to develop a valid quality-of-life (QOL) caregiver-reported survey instrument, RhizoQOL, to be used as an endpoint in RCDP clinical trials.
Methods
Development of the RhizoQOL survey tool included three RCDP caregiver focus groups to elicit concepts to serve as potential domains in a QOL survey instrument for RCDP, pilot survey development and initial testing, cognitive interviewing of revised survey drafts to determine content validity, as well as a three-month longitudinal study for reliability and internal consistency of the survey instrument.
Results
Twenty-eight caregivers participated in the focus groups, reporting that concepts that could be appropriate domains of QOL in RCDP include psychosocial behavior, feeding symptoms, mobility symptoms, respiratory symptoms, seizures and related activity, and impact of treatment. Following pilot survey testing (n = 22) and stakeholder feedback, a revised pilot survey instrument was administered to five caregivers for cognitive interviewing. This resulted in a revised survey instrument with 31 question items, six domains, and a 1–5 Likert scale item response assessing frequency or severity of event in the question item. Longitudinal testing (n = 18) of the revised survey instrument found the average response score was 1.98 ± 0.97 for all question items, and a Cronbach’s alpha value of 0.856, suggesting strong intra-survey question reliability. Using individual question item results from reliability testing, linear regression modeling, and testing for required magnitude of significant treatment effects, eight question items were removed from the survey instrument, resulting in a total of 23 question items within 6 discrete domains.
Conclusions
The final RhizoQOL survey instrument, consisting of 23 questions, assesses the symptoms and experiences of RCDP patients as observed by caregivers and serves as a novel clinical outcome assessment for RCDP therapeutic clinical trials to assess the impacts of RCDP and the effectiveness of treatments.
WITHDRAWN: Developing a Risk Model of Lipid Metabolism-associated Genes: Implications for Clinical Prognosis and Tumor Immune Microenvironment in Gastric Cancer
Authors: Xiao Yanan , Yu Qin , Zhu Zewen , Zhou Shan , Wu Zhe , Luo Xin , Peng Hui , Zhan Zhiqiang 
Published: October 2024

Abstract

The full text of this preprint has been withdrawn by the authors in order to comply with an institutional policy on preprints. Therefore, the authors do not wish this work to be cited as a reference.
Modified abdominal advancement flap with the Ochikomanai method: Oncoplastic surgery with a simple volume replacement technique
Authors: Hatakawa Erina , Kojima Rena , Yamaguchi Ayu , Nakamura Kaho , Yamakado Rena , Watanabe Sari , Yoshikawa Miyuko , Shibusawa Mai , Kimoto Mao , Imai Nao , Ishitobi Makoto , Kawaguchi Kousuke , Ogawa Tomoko 
Published: October 2024

Abstract

Background Breast-conserving surgery (BCS) of the lower portion of the breast results in poor cosmetic outcomes. Therefore, a simple and suitable technique for performing BCS for breast cancer in the lower region is needed. In 2010, we developed an abdominal advancement flap (AAF) as a simple technique. However, BCS with an AAF could have worse cosmetic results when used in older patients and those with larger breasts. Therefore, we developed the even simpler volume replacement technique based on the AAF in 2017, called the “modified AAF.”Methods We conducted a retrospective cohort study focusing on the usefulness of the modified AAF, including cosmetic results and patient satisfaction, in 88 patients (89 breasts) who underwent BCS using the modified AAF with or without the Ochikomanai method.Results Ten patients had complications (11%); however, no fat necrosis was observed, and all complications improved with conservative treatment. With regard to cosmetic results, 41 breasts (58%) were rated excellent, 26 breasts (37%) were rated good, and only 4 were unacceptable, all of which were rated fair. Patients with medium- or larger-sized breasts and older patients who underwent BCS using modified AAF with or without the Ochikomanai method had acceptable cosmetic results. More than 89% of patients indicated they were somewhat or very satisfied in all eight categories, except for physical limitations in the immediate postoperative period.Conclusion BCS using a modified AAF, with or without the Ochikomanai method, is a useful technique for many patients, including patients who are older or have larger breasts.
The lost chILD: a case report of delayed diagnosis of Surfactant Protein C Deficiency in a 15-year-old African male
Authors: Faelli Nadia , Chironi Federica , Andrenacci Beatrice , Patria Maria Francesca , Ferrero Stefano , Borzani Irene , Pucci Costanza , Civeriati Daniela , Lelii Mara , Madini Barbara , Rocchi Alessia , Daccò Valeria 
Published: October 2024

Abstract

Background: Childhood interstitial lung disease (chILD) encompasses a heterogeneous group of rare disorders characterized by respiratory distress, hypoxemia, exercise intolerance, and distinctive radiological findings. Despite the variable age of onset, these conditions often present with overlapping symptoms and variable progression, even with identical genetic mutations. Surfactant protein deficiencies fall under the category of child, with Surfactant Protein-C (SP-C) deficiency posing significant diagnostic challenges due to its rarity and nonspecific symptoms that may be overlooked.
Case presentation: We present the case of a 15-year-old male from Senegal who recently arrived in Italy, presenting with severe respiratory distress and hypoxemia. The patient, born full-term, had a long history of chronic cough, recurrent respiratory distress, and poor growth since early infancy.
Upon hospitalization, he tested positive for SARS-CoV-2 and exhibited signs of chronic respiratory failure and severe malnutrition. An extensive diagnostic work-up, including a chest CT scan, revealed small cystic-like air spaces and diffuse ground-glass opacities. Whole-exome sequencing confirmed the diagnosis of SP-C deficiency by identifying a heterozygous missense mutation (c.218t>C, Ile73Thr) in the third exon of the SFTPC gene. Treatment with steroids, azithromycin and hydroxychloroquine was initiated. Despite pharmacological treatments, the patient remained oxygen dependent due to the severity of this condition and required long-term bilevel non-invasive ventilatory support.
Conclusions: This case provides unique insight into the natural course of untreated child, specifically SP-C deficiency, enhancing our understanding of its manifestations and progression. The lack of standardized treatments underscores the critical need for increased awareness among physicians of this rare but potentially life-threatening condition, enabling early diagnosis and timely therapeutic interventions.
Impact of High-Protein Diets on Weight Loss Programs: Analyzing Loss of Muscle and Skeletal Mass
Authors: Ma Yahui , Sun Lina , Mu Zhijing 
Published: October 2024

Abstract

Objective
The objective of this probe is to determine the effects of High-Protein Diets (HPD) on weight loss programs.
Methodology
From January 2021 to May 2022, 133 patients, who were enrolled in a Chinese-based weight loss program, participated in a clinical trial aimed at investigating the impact of High-Protein Diets (HPD) on weight loss programs. The effects of the diet plan on the patients’ insulin, hemoglobin, and Vitamin D levels were assessed and the findings examined to evaluate the impact of HPD on muscle and skeletal mass.
Results and Findings
HPD was useful in catalyzing the effectiveness of weight loss programs. It led to reductions in skeletal and muscle mass during the trial period based on its impact on insulin, hemoglobin, and Vitamin D levels among the trial population.