bluuebunny/crossref_metadata_2025_split huggingface dataset:
With Love and Kisses: Nothing Lasts Forever: An Examination of the Social and Artistic Antiquation of Moral Rights
Authors: Lewis Jessica 
Published: October 2016

Abstract:This article examines the social and artistic antiquation of moral rights law. Moral rights law developed, and was implemented, under the heavy influence of the French preference to put the rights of the author at the center of intellectual property protection (with Victor Hugo leading this charge). However, as artistic practice evolves in a continually rapid fashion, it is becoming increasingly clear that moral rights are unable to properly accord with modern art forms. An examination of the social construction of authorship, the emergence of unique contemporary art forms, and the role of technology as a catalyst to intellectual property law, reveals that the Western world’s legal moral rights scheme cannot survive its current form. Moral rights’ endurance hinges on its ability to reconcile with a social and artistic climate alien to its origins. Artistic expression does not exist in a vacuum and is inextricably linked to, and reflective of, the social climate it is born out of. As society evolves and shifts, so too does its art and so must the law.
Goats with aspartic acid or serine at codon 146 of the PRNP gene remain scrapie-negative after lifetime exposure in affected herds in Cyprus
Authors: GEORGIADOU S. , ORTIZ-PELAEZ A. , SIMMONS M. M. , WINDL O. , DAWSON M. , NEOCLEOUS P. , PAPASAVVA-STYLIANOU P. 
Published: October 2016

SUMMARYThe results of the study reported here are part of an ongoing integrated research programme aimed at producing additional, robust, evidence on the genetic resistance to classical scrapie in goats, with particular reference to codon 146. The study targeted animals aged ⩾6 years, which were born and raised in infected herds and were being culled for management reasons. A total of 556 animals were tested, and all positive animals (n = 117) were of the susceptible NN genotype. A total of 246 goats heterozygous or homozygous for putatively resistant alleles (S146 and D146) were screened with no positive results. The outcome of this study supports the hypothesis that the D146 and S146 alleles could be used as the basis for a nationwide strategy for breeding for resistance in the Cypriot goat population.
Longitudinal Executive Function and Episodic Memory Profiles in Behavioral-Variant Frontotemporal Dementia and Alzheimer’s Disease
Authors: Ramanan Siddharth , Bertoux Maxime , Flanagan Emma , Irish Muireann , Piguet Olivier , Hodges John R. , Hornberger Michael 
Published: October 2016

AbstractObjectives:With comparable baseline performance on executive functions (EF) and memory between Alzheimer’s disease (AD) and behavioral-variant frontotemporal dementia (bvFTD), it is currently unclear if both diseases can be distinguished longitudinally on these measures reliably.Methods:A total of 111 participants (33 AD, 31 bvFTD, and 47 controls) were followed-up annually over a 4-year period and tested on measures of EF, memory, and orientation. Linear mixed-effect models were constructed using disease severity as a nuisance variable to examine profiles of neuropsychological performance decline.Results:At baseline, overlap in terms of cognitive impairment between bvFTD and AD on multiple EF, memory, and orientation measures was present. Longitudinally, only disinhibition (Hayling total errors) appeared sensitive to discriminating AD from bvFTD; however, only after the first annual follow-up. Subgroup analyses on smaller samples revealed comparable profiles on EF tasks at baseline and over time between bvFTD and AD who presented with impaired EF at presentation, and on memory and orientation tasks between AD and bvFTD who presented with severe amnesia.Conclusions:Our results replicate previous findings showing only moderate discriminability between AD and bvFTD at clinical presentation on EF and memory measures. More importantly, we also show that longitudinal trajectories strongly overlap for both dementias on these measures. Disinhibition emerged as the sole measure that in the long run was significantly more impaired in bvFTD. Future studies should use tests designed to target cortical regions that are specifically impaired in bvFTD, such as the ventromedial prefrontal cortex, to improve the accurate discrimination of these diseases. (JINS, 2017,23, 34–43)
The ICRC in the First World War: Unwavering belief in the power of law?
Authors: Cameron Lindsey 
Published: October 2016

AbstractThis article provides insight into how, during the First World War, the ICRC handled the oversight of the respect of the 1906 Convention on the Wounded and Sick and the 1907 Hague Convention on Maritime Warfare, steadfastly working to uphold the law. It examines the ICRC's view on the applicability of the Conventions, describes its handling of accusations of violations of international humanitarian law and, finally, shows how the ICRC engaged in a legal dialogue with States on the interpretation of various provisions in the 1906 Convention.
A pulse of mid-Pleistocene rift volcanism in Ethiopia at the dawn of modern humans
Authors: Hutchison William , Fusillo Raffaella , Pyle David M. , Mather Tamsin A. , Blundy Jon D. , Biggs Juliet , Yirgu Gezahegn , Cohen Benjamin E. , Brooker Richard A. , Barfod Dan N. , Calvert Andrew T. 
Published: October 2016

AbstractThe Ethiopian Rift Valley hosts the longest record of human co-existence with volcanoes on Earth, however, current understanding of the magnitude and timing of large explosive eruptions in this region is poor. Detailed records of volcanism are essential for interpreting the palaeoenvironments occupied by our hominin ancestors; and also for evaluating the volcanic hazards posed to the 10 million people currently living within this active rift zone. Here we use new geochronological evidence to suggest that a 200 km-long segment of rift experienced a major pulse of explosive volcanic activity between 320 and 170 ka. During this period, at least four distinct volcanic centres underwent large-volume (>10 km3) caldera-forming eruptions, and eruptive fluxes were elevated five times above the average eruption rate for the past 700 ka. We propose that such pulses of episodic silicic volcanism would have drastically remodelled landscapes and ecosystems occupied by early hominin populations.
Visible quantum plasmonics from metallic nanodimers
Authors: Alpeggiani F. , D’Agostino S. , Sanvitto D. , Gerace D. 
Published: October 2016

AbstractWe report theoretical evidence that bulk nonlinear materials weakly interacting with highly localized plasmonic modes in ultra-sub-wavelength metallic nanostructures can lead to nonlinear effects at the single plasmon level in the visible range. In particular, the two-plasmon interaction energy in such systems is numerically estimated to be comparable with the typical plasmon linewidths. Localized surface plasmons are thus predicted to exhibit a purely nonclassical behavior, which can be clearly identified by a sub-Poissonian second-order correlation in the signal scattered from the quantized plasmonic field under coherent electromagnetic excitation. We explicitly show that systems sensitive to single-plasmon scattering can be experimentally realized by combining electromagnetic confinement in the interstitial region of gold nanodimers with local infiltration or deposition of ordinary nonlinear materials. We also propose configurations that could allow to realistically detect such an effect with state-of-the-art technology, overcoming the limitations imposed by the short plasmonic lifetime.
Metallomic Biomarkers in Cerebrospinal fluid and Serum in patients with Parkinson’s disease in Indian population
Authors: Sanyal Jaya , Ahmed Shiek S. S. J. , Ng Hon Keung Tony , Naiya Tufan , Ghosh Epsita , Banerjee Tapas Kumar , Lakshmi Jaya , Guha Gautam , Rao Vadlamudi Raghavendra 
Published: October 2016

AbstractParkinson's disease (PD) is a neurodegenerative disease with the absence of markers for diagnosis. Several studies on PD reported the elements imbalance in biofluids as biomarkers. However, their results remained inconclusive. This study integrates metallomics, multivariate and artificial neural network (ANN) to understand element variations in CSF and serum of PD patients from the largest cohort of Indian population to solve the inconsistent results of previous studies. Also, this study is aimed to (1) ascertain a common element signature between CSF and serum. (2) Assess cross sectional element variation with clinical symptoms. (3) Develop ANN models for rapid diagnosis. A metallomic profile of 110 CSF and 530 serum samples showed significant variations in 10 elements of CSF and six in serum of patients compared to controls. Consistent variations in elements pattern were noticed for Calcium, Magnesium and Iron in both the fluids of PD, which provides feasible diagnosis from serum. Furthermore, implementing multivariate analyses showed clear classification between normal and PD in both the fluids. Also, ANN provides 99% accuracy in detection of disease from CSF and serum. Overall, our analyses demonstrate that elements profile in biofluids of PD will be useful in development of diagnostic markers for PD.
On the possibility of many-body localization in a doped Mott insulator
Authors: He Rong-Qiang , Weng Zheng-Yu 
Published: October 2016

AbstractMany-body localization (MBL) is currently a hot issue of interacting systems, in which quantum mechanics overcomes thermalization of statistical mechanics. Like Anderson localization of non-interacting electrons, disorders are usually crucial in engineering the quantum interference in MBL. For translation invariant systems, however, the breakdown of eigenstate thermalization hypothesis due to a pure many-body quantum effect is still unclear. Here we demonstrate a possible MBL phenomenon without disorder, which emerges in a lightly doped Hubbard model with very strong interaction. By means of density matrix renormalization group numerical calculation on a two-leg ladder, we show that whereas a single hole can induce a very heavy Nagaoka polaron, two or more holes will form bound pair/droplets which are all localized excitations with flat bands at low energy densities. Consequently, MBL eigenstates of finite energy density can be constructed as composed of these localized droplets spatially separated. We further identify the underlying mechanism for this MBL as due to a novel ‘Berry phase’ of the doped Mott insulator, and show that by turning off this Berry phase either by increasing the anisotropy of the model or by hand, an eigenstate transition from the MBL to a conventional quasiparticle phase can be realized.
Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes
Authors: Li Jing-Woei , Lee Heung-Man , Wang Ying , Tong Amy Hin-Yan , Yip Kevin Y. , Tsui Stephen Kwok-Wing , Lok Si , Ozaki Risa , Luk Andrea O , Kong Alice P. S. , So Wing-Yee , Ma Ronald C. W. , Chan Juliana C. N. , Chan Ting-Fung 
Published: October 2016

AbstractProtein interactions play significant roles in complex diseases. We analyzed peripheral blood mononuclear cells (PBMC) transcriptome using a multi-method strategy. We constructed a tissue-specific interactome (T2Di) and identified 420 molecular signatures associated with T2D-related comorbidity and symptoms, mainly implicated in inflammation, adipogenesis, protein phosphorylation and hormonal secretion. Apart from explaining the residual associations within the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) study, the T2Di signatures were enriched in pathogenic cell type-specific regulatory elements related to fetal development, immunity and expression quantitative trait loci (eQTL). The T2Di revealed a novel locus near a well-established GWAS loci AChE, in which SRRT interacts with JAZF1, a T2D-GWAS gene implicated in pancreatic function. The T2Di also included known anti-diabetic drug targets (e.g. PPARD, MAOB) and identified possible druggable targets (e.g. NCOR2, PDGFR). These T2Di signatures were validated by an independent computational method, and by expression data of pancreatic islet, muscle and liver with some of the signatures (CEBPB, SREBF1, MLST8, SRF, SRRT and SLC12A9) confirmed in PBMC from an independent cohort of 66 T2D and 66 control subjects. By combining prior knowledge and transcriptome analysis, we have constructed an interactome to explain the multi-layered regulatory pathways in T2D.
Protein tyrosine phosphatase 1B targets PITX1/p120RasGAP thus showing therapeutic potential in colorectal carcinoma
Authors: Teng Hao-Wei , Hung Man-Hsin , Chen Li-Ju , Chang Mao-Ju , Hsieh Feng-Shu , Tsai Ming-Hsien , Huang Jui-Wen , Lin Chih-Lung , Tseng Hsiang-Wen , Kuo Zong-Keng , Jiang Jeng-Kai , Yang Shung-Haur , Shiau Chung-Wai , Chen Kuen-Feng 
Published: October 2016

AbstractProtein tyrosine phosphatase 1B (PTP1B) is known to promote the pathogenesis of diabetes and obesity by negatively regulating insulin and leptin pathways, but its role associated with colon carcinogenesis is still under debate. In this study, we demonstrated the oncogenic role of PTP1B in promoting colon carcinogenesis and predicting worse clinical outcomes in CRC patients. By co-immunoprecipitation, we showed that PITX1 was a novel substrate of PTP1B. Through direct dephosphorylation at Y160, Y175 and Y179, PTP1B destabilized PITX1, which resulted in downregulation of the PITX1/p120RasGAP axis. Interestingly, we found that regorafenib, the approved target agent for advanced CRC patients, exerted a novel property against PTP1B. By inhibiting PTP1B activity, regorafenib treatment augmented the stability of PITX1 protein and upregulated the expression of p120RasGAP in CRC. Importantly, we found that this PTP1B-dependant PITX1/p120RasGAP axis determines the in vitro anti-CRC effects of regorafenib. The above-mentioned effects of regorafenib were confirmed by the HT-29 xenograft tumor model. In conclusion, we demonstrated a novel oncogenic mechanism of PTP1B on affecting PITX1/p120RasGAP in CRC. Regorafenib inhibited CRC survival through reserving PTP1B-dependant PITX1/p120RasGAP downregulation. PTP1B may be a potential biomarker predicting regorafenib effectiveness, and a potential solution for CRC.
Altered T cell phenotypes associated with clinical relapse of multiple sclerosis patients receiving fingolimod therapy
Authors: Fujii Chihiro , Kondo Takayuki , Ochi Hirofumi , Okada Yoichiro , Hashi Yuichiro , Adachi Tetsuya , Shin-Ya Masaharu , Matsumoto Sadayuki , Takahashi Ryosuke , Nakagawa Masanori , Mizuno Toshiki 
Published: October 2016

AbstractMultiple sclerosis (MS) is a T cell-mediated autoimmune disease. Fingolimod, a highly effective disease-modifying drug for MS, retains CCR7+ central memory T cells in which autoaggressive T cells putatively exist, in secondary lymphoid organs, although relapse may still occur in some patients. Here, we analyzed the T cell phenotypes of fingolimod-treated, fingolimod-untreated patients, and healthy subjects. The frequency of CD56+ T cells and granzyme B-, perforin-, and Fas ligand-positive T cells significantly increased during fingolimod treatment. Each T cell subpopulation further increased during relapse. Interestingly, T cells from fingolimod-treated patients exhibited interferon-γ biased production, and more myelin basic protein-reactive cells was noted in CD56+ than in CD56− T cells. It is likely that the altered T cell phenotypes play a role in MS relapse in fingolimod-treated patients. Further clinical studies are necessary to investigate whether altered T cell phenotypes are a biomarker for relapse under fingolimod therapy.
Myc overexpression enhances epicardial contribution to the developing heart and promotes extensive expansion of the cardiomyocyte population
Authors: Villa del Campo Cristina , Lioux Ghislaine , Carmona Rita , Sierra Rocío , Muñoz-Chápuli Ramón , Clavería Cristina , Torres Miguel 
Published: October 2016

AbstractMyc is an essential regulator of cell growth and proliferation. Myc overexpression promotes the homeostatic expansion of cardiomyocyte populations by cell competition, however whether this applies to other cardiac lineages remains unknown. The epicardium contributes signals and cells to the developing and adult injured heart and exploring strategies for modulating its activity is of great interest. Using inducible genetic mosaics, we overexpressed Myc in the epicardium and determined the differential expansion of Myc-overexpressing cells with respect to their wild type counterparts. Myc-overexpressing cells overcolonized all epicardial-derived lineages and showed increased ability to invade the myocardium and populate the vasculature. We also found massive colonization of the myocardium by Wt1Cre-derived Myc-overexpressing cells, with preservation of cardiac development. Detailed analyses showed that this contribution is unlikely to derive from Cre activity in early cardiomyocytes but does not either derive from established epicardial cells, suggesting that early precursors expressing Wt1Cre originate the recombined cardiomyocytes. Myc overexpression does not modify the initial distribution of Wt1Cre-recombined cardiomyocytes, indicating that it does not stimulate the incorporation of early expressing Wt1Cre lineages to the myocardium, but differentially expands this initial population. We propose that strategies using epicardial lineages for heart repair may benefit from promoting cell competitive ability.
DNA damage precedes apoptosis during the regression of the interdigital tissue in vertebrate embryos
Authors: Montero Juan A. , Sanchez-Fernandez Cristina , Lorda-Diez Carlos I. , Garcia-Porrero Juan A. , Hurle Juan M. 
Published: October 2016

AbstractDNA damage independent of caspase activation accompanies programmed cell death in different vertebrate embryonic organs. We analyzed the significance of DNA damage during the regression of the interdigital tissue, which sculpts the digits in the embryonic limb. Interdigit remodeling involves oxidative stress, massive apoptosis and cell senescence. Phosphorylation of H2AX mediated by ATM precedes caspase dependent apoptosis and cell senescence during interdigit regression. The association of γH2AX with other downstream DNA repair factors, including MDC1, Rad50 and 53BP1 suggests a defensive response of cells against DNA damage. The relative distribution of cells γH2AX-only positive, TUNEL-only positive, and cells double positive for both markers is consistent with a sequence of degenerative events starting by damage of the DNA. In support of this interpretation, the relative number of γH2AX-only cells increases after caspase inhibition while the relative number of TUNEL-only cells increases after inhibition of ATM. Furthermore, cultured interdigits survived and maintained intense chondrogenic potential, even at advanced stages of degeneration, discarding a previous commitment to die. Our findings support a new biological paradigm considering embryonic cell death secondary to genotoxic stimuli, challenging the idea that considers physiological cell death a cell suicide regulated by an internal death clock that pre-programmes degeneration.
Targeted Downregulation of s36 Protein Unearths its Cardinal Role in Chorion Biogenesis and Architecture during Drosophila melanogaster Oogenesis
Authors: Velentzas Athanassios D. , Velentzas Panagiotis D. , Sagioglou Niki E. , Konstantakou Eumorphia G. , Anagnostopoulos Athanasios K. , Tsioka Maria M. , Mpakou Vassiliki E. , Kollia Zoe , Consoulas Christos , Margaritis Lukas H. , Papassideri Issidora S. , Tsangaris George Th. , Sarantopoulou Evangelia , Cefalas Alkiviadis-Constantinos , Stravopodis Dimitrios J. 
Published: October 2016

AbstractDrosophila chorion represents a model biological system for the in vivo study of gene activity, epithelial development, extracellular-matrix assembly and morphogenetic-patterning control. It is produced during the late stages of oogenesis by epithelial follicle cells and develops into a highly organized multi-layered structure that exhibits regional specialization and radial complexity. Among the six major proteins involved in chorion’s formation, the s36 and s38 ones are synthesized first and regulated in a cell type-specific and developmental stage-dependent manner. In our study, an RNAi-mediated silencing of s36 chorionic-gene expression specifically in the follicle-cell compartment of Drosophila ovary unearths the essential, and far from redundant, role of s36 protein in patterning establishment of chorion’s regional specialization and radial complexity. Without perturbing the developmental courses of follicle- and nurse-cell clusters, the absence of s36 not only promotes chorion’s fragility but also induces severe structural irregularities on chorion’s surface and entirely impairs fly’s fertility. Moreover, we herein unveil a novel function of s36 chorionic protein in the regulation of number and morphogenetic integrity of dorsal appendages in follicles sporadically undergoing aged fly-dependent stress.
Lithium-Decorated Borospherene B40: A Promising Hydrogen Storage Medium
Authors: Bai Hui , Bai Bing , Zhang Lin , Huang Wei , Mu Yue-Wen , Zhai Hua-Jin , Li Si-Dian 
Published: October 2016

AbstractThe recent discovery of borospherene B40 marks the onset of a new kind of boron-based nanostructures akin to the C60 buckyball, offering opportunities to explore materials applications of nanoboron. Here we report on the feasibility of Li-decorated B40 for hydrogen storage using the DFT calculations. The B40 cluster has an overall shape of cube-like cage with six hexagonal and heptagonal holes and eight close-packing B6 triangles. Our computational data show that Lim&B40(1–3) complexes bound up to three H2 molecules per Li site with an adsorption energy (AE) of 0.11–0.25 eV/H2, ideal for reversible hydrogen storage and release. The bonding features charge transfer from Li to B40. The first 18 H2 in Li6&B40(3) possess an AE of 0.11–0.18 eV, corresponding to a gravimetric density of 7.1 wt%. The eight triangular B6 corners are shown as well to be good sites for Li-decoration and H2 adsorption. In a desirable case of Li14&B40-42 H2(8), a total of 42 H2 molecules are adsorbed with an AE of 0.32 eV/H2 for the first 14 H2 and 0.12 eV/H2 for the third 14 H2. A maximum gravimetric density of 13.8 wt% is achieved in 8. The Li-B40-nH2 system differs markedly from the previous Li-C60-nH2 and Ti-B40-nH2 complexes.