bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patients with metastatic castration-resistant prostate cancer (mCRPC) are primary resistant (PR) to the new agent (NA)-based second line: Clinical outcomes and prognostic factors of subsequent treatment with another NA.
Authors: Caffo Orazio , Bria Emilio , De Giorgi Ugo , Tucci Marcello , Biasco Elisa , Fratino Lucia , Rossetti Sabrina , Iacovelli Roberto , Morelli Franco , D'Angelo Alessandro , Campadelli Enrico , Verderame Francesco , Borsellino Nicolo , Sartori Donata , Guida Annalisa , Ricotta Riccardo , Barni Sandro , Maines Francesca , Sperduti Isabella , Zagonel Vittorina 
Published: March 2017

e585 Background: Several NA [abiraterone acetate (AA), cabazitaxel (CABA), or enzalutamide (ENZ)] changed the prognosis of mCRPC pts being able to significantly prolong their overall survival (OS) after docetaxel failure. Unfortunately, a quote of pts experiences an early progression (within 3 mos) during the second line treatment and it is unclear if a clinical benefit may result from a subsequent treatment with another NA. The present study is aimed to assess the clinical outcomes and prognostic factors of subsequent NA treatment in those pts PR to the second line NA. Methods: We collected data of pts who received sequentially two NAs after DOC in 38 Italian hospitals. For each pt we recorded the clinical outcome of all treatments received after DOC. For the purpose of the present analysis we consider as PR pts who progressed within 3 months from the start of the NA second line. Cox regression analysis was used to assess the independent prognostic value of a series of third-line baseline covariates, in terms of progression free survival (PFS) and OS. Results: A consecutive series of 476 mCRPC pts with bone (86%), nodal (56%) or visceral (15%) mets, was collected. The NA-based second line consisted of AA (261 pts), CABA (151), and ENZ (64): we identified 55 PR pts (AA 24 – CABA 24 – ENZ 7). All pts received a subsequent NA-based third line: 22 received AA, 25 CABA, and 8 ENZ. Compared to no-PR pts, PR pts showed a lower biochemical response rate (12.2% vs 31.6%; p = 0.005), but no significant differences in terms of objective response rate (17.1% vs 15.2%), PFS (median 3.5 vs 4.7 mos), and OS (median 9.4 vs 12.9 mos). Considering the PR population, at the multivariate analysis , lactate dehydrogenase and PSA were independent prognostic factors for PFS in third line, while hemoglobin, PSA, administration of one NA in fourth line and lactate dehydrogenase were independent prognostic factors for OS. Conclusions: In our experience, NA-based third line is active also in mCRPC PR population and some factors may help in selecting patients with higher probability of achieving a disease control.
Is there an additional benefit of Tc-99m-PSMA-guided gamma probe use for salvage lymph node dissection in recurrent prostate cancer.
Authors: Pfister David , Schmidt Matthias , Haidl Friederike , Porres-Knoblauch Daniel , Drzezga Alexander , Heidenreich Axel 
Published: March 2017

e591 Background: PSMA-PET/CT is the most sensitive diagnostic tool in biochemical recurrent prostate cancer to detect minimal metastatic disease. However, it may be difficult to localize small PSMA-positive lymph nodes intraoperatively. Therefore, it was the aim to investigate whether preoperative Tc-99m-PSMA targeting may improve intraoperative tumor localization by use of a gamma probe. Methods: In 13 Patients Ga-68-PSMA-PET/CT identified iliac lymph nodes in patients suitable for salvage lymph node dissection. On the day before operation a mean activity of 480 MBq Tc-99m-PSMA was injected and gamma camera scintigraphy + SPECT was performed 4-5 hours after tracer application. About 24 hours after tracer application a salvage lymph node dissection was performed on the side of initial suspicious lymph node metastases. Sensitivity, specifity, pos and neg. predictive values were calulated for PSMA-PET/CT and gamma probe use to analyse the additional use. Results: In 9 / 13 patients PSMA-positive metastatic lymph nodes were identified in Ga-68 PSMA-PET/CT. A total of 156 lymph nodes were removed with 14 lymph nodes in 9 patients being positive in histopathologic examination. Sensitivity, specifity, pos and neg. predictive values for PSMA PET/CT and gamma probe were 85% and 79%, 99% and 100%, 85% and 100% and 99% and 98% respectively. In one patient only gamma probe use identified a pathologic lymph node. Conclusions: Gamma probe guided salvage lymph node dissection in PSA recurrent prostate cancer is feasible and had a high concordance with PSMA-PET/CT. However, the additional diagnostic benefit is limited compared to PSMA-PET/CT because in only one patient (7%) a positive lymph node could be identified with the use of the gamma probe outside the standard operative area in salvage lymph node dissection.
Predictors for survival with cabazitaxel (CBZ) in metastatic, castration-resistant prostate cancer (mCRPC): Long term follow-up of the Spanish registry.
Authors: González-Maeso Iria , Lainez Nuria , Castellano Daniel , Garcia Carbonero Iciar , Borrega Pablo , Campos Balea Begona , Garcia Marrero Rosa , Esteban Emilio , Rodriguez Vida Alejo , Munarriz Javier , Garcia-Bueno Jose Maria , Villalobos Maria L. , Viciana Ruth , Rubio Gustavo , Perez-Valderrama Begoña , Garcia Sanchez Jose , Pelaez Lorenzo Beatriz , Cumplido Buron Jose David , Martin Almudena , Bellmunt Joaquim 
Published: March 2017

e602 Background: The clinical experience with CBZ in mCRPC patients (pts) has enriched notably since its approval for clinical use, but there is still a lack of well-defined prognostic/predictive factors to better characterize the profile of pts that could achieve the best therapeutic benefit. Analysis of the final expanded cohort and mature long-term follow-up are presented. Methods: Medical records from mCRPC pts progressing during or after docetaxel and treated with CBZ at 21 centres in Spain were reviewed retrospectively. Baseline characteristics, overall survival (OS), radiographic progression-free survival (rPFS), and toxicity were collected. Univariate and multivariate analysis of a variety of factors predicting OS were conducted. Results: 187 consecutive pts (median age 69) with intermediate-poor prognostic baseline characteristics (Table 1) received a median of 6 cycles (range 2-59) of CBZ. Median OS from first CBZ cycle was 15.3 [CI: 11.7; 18.0] months (mo) and median clinical and/or rPFS was 7.9 mo [CI: 6.8; 10.3]. Gleason score (GS) < 8 (vs ≥ 8), time under first-line androgen deprivation therapy (ADT) ( > 16.1 (median) vs < 16.1 mo) and the number of chemotherapy lines before CBZ did not significantly influence OS. Median follow-up was 9.5 mo. Febrile neutropenia occurred in 4 pts and 1 pt had neutropenic infection. Main nonhematologic grade ≥ 3 toxicities were asthenia (2.7%) and diarrhea (1.6%). Alopecia, nails disorders and peripheral neuropathy were uncommon. Conclusions: CBZ administered in the daily clinical practice is associated with consistent OS, similar to that observed in pivotal clinical trials. GS, median time under first-line ADT and number of chemotherapy lines before CBZ did not influence clinical benefit. CBZ has an acceptable safety profile. Funding: Sanofi [Table: see text]
INFLUENCE OF DENSITY AND LENGTH OF CUTTING OF BASALT FIBER ON PHYSICAL AND MECHANICAL INDICATORS OF COMPOSITE DISPERSION-REINFORCED ASPHALT-CONCRETE MIXTURE
Authors: Андронов Сергей , Andronov Sergey , Задирака Алексей , Zadiraka Aleksey 
Published: March 2017

Experiments on the introduction of basalt fiber with various density and length of cutting into the composition of the dispersed-reinforced asphalt mixture were carried out, laboratory tests of asphalt concrete samples were carried out, the optimal density and length of cutting basalt fiber for introduction into asphalt concrete mixtures
In transport construction, asphalt concrete is widely used, which is prone to cracking, peeling, chipping, formation of stakes, waves and depressions. The way to increase the resistance of asphalt concrete to external loads is the introduction of fibers and threads into its composition. Introduction to the asphalt-concrete mixture of small (discrete) elements allows to achieve their uniform distribution (dispersion) in the mixture, and to obtain a &#34;composite&#34; material with higher physical and mechanical properties in the finished structural element
Acquisitions, Node Collapse, and Network Revolution
Authors: Hernandez Exequiel , Menon Anoop 
Published: March 2017

We explore a novel mechanism of network change that occurs when a firm acquires another one and inherits its network ties. Such “node collapse” can radically restructure the network in one transaction, constituting a revolutionary change compared with the incremental effect of tie additions and deletions, which have been the focus of prior research. We explore several properties of node collapses: their efficacy in helping firms achieve superior network positions, the externalities they impose on other network actors, and how they provide exclusive control over both internal and network resources. Using a simulation in which actors compete to acquire one another, we model network dynamics driven by node collapses. We find that node collapses directly affect the performance of the acquirer and indirectly that of other actors, and that the direction of network evolution hinges on the degree to which firms pursue internal versus network synergies through node collapses. This paper was accepted by Olav Sorenson, organizations.
Salary Cap system in NBA and adaptability to Turkish basketball leagues<p>NBA’de uygulanan Salary Cap sistemi ve Türkiye basketbol liglerine uyarlanabilirliği
Authors: Ötkan Can Çavin , Çolakoğlu Tekin 
Published: March 2017

In this study; It is aimed to examine the structure of the NBA, which is at the top of world basketball's many different parameters such as prestige, brand value and rating, and to examine the Salary Cap system that shaped the NBA organization economically in terms of the data obtained with the literature review. In addition to this, the details of the Salary Cap system, its effects on the world basketball, the current developments related to the subject and adaptation to Turkish basketball have been examined with its positive and negative aspects. The current structure of Turkish basketball has been evaluated specifically for men's basketball leagues and financial implementation have been interpreted with positive and negative aspects. A detailed literature search method based on the literature was used in the study and the obtained data related to the subject were synthesized thematically.As a result, it was observed that the Salary Cap system, which is being implemented in the NBA organization, positively affected the brand value of the league, the sustainability of competition and the economic stability of the clubs and it would be beneficial for the Turkish sport if the similar application was adapted to the Turkish basketball within the country conditions and the work on the financial criteria was rearranged. ÖzetBu çalışmada; dünya basketbolunun prestij, marka değeri ve izlenilirlik gibi pek çok farklı parametresine bakıldığında zirvede yer aldığı görülen NBA organizasyonunun tarihsel gelişiminin ve söz konusu organizasyonu ekonomik anlamda şekillendiren Salary Cap sisteminin, literatür taraması ile birlikte elde edilen bilgi ve veriler ışığında incelenmesi amaçlanmıştır. Bunun yanı sıra, Salary Cap sisteminin detayları, olumlu ve olumsuz yönleri ile birlikte irdelenerek dünya basketboluna olan etkisi, konuya ilişkin yaşanan güncel gelişmeler ve söz konusu detaylar dahilinde Türk basketboluna adapte edilebilir özellikleri ortaya konulmak istenmiştir. Türk basketbolunun mevcut yapısı, erkek basketbol ligleri özelinde değerlendirilmiş ve mali uygulamalar yine pozitif ve negatif yanlarıyla birlikte yorumlanmıştır. Çalışmada literatüre dayalı detaylı kaynak taraması metodu kullanılmış ve konuya ilişkin elde edilen veriler sentezlenerek tematik olarak derlenmiştir. Sonuç olarak baktığımızda ise, NBA organizasyonunda uygulanmakta olan Salary Cap sisteminin, ligin marka değerine, rekabetin sürdürülebilirliğine ve kulüplerin ekonomik istikrarına olumlu yönde etki ettiği görülmüş, benzer uygulamanın ülke şartları dahilinde Türk basketboluna uyarlanması ve mali kriterler ekseninde yapının yeniden düzenlenmesi durumunda, Türk sporu adına olumlu bir adım atılacağı kanaatine ulaşılmıştır.
Concerted regulation of renal plasma flow and glomerular filtration rate by renal dopamine and NOS I in rats on high salt intake
Authors: Ibarra Mariano E. , Albertoni Borghese Maria F. , Majowicz Mónica P. , Ortiz María C. , Loidl Fabián , Rey‐Funes Manuel , Di Ciano Luis A. , Ibarra Fernando R. 
Published: March 2017

AbstractUnder high sodium intake renal dopamine (DA) increases while NOS I expression in macula densa cells (MD) decreases. To explore whether renal DA and NOS I, linked to natriuresis and to the stability of the tubuloglomerular feedback, respectively, act in concert to regulate renal plasma flow (RPF) and glomerular filtration rate (GFR). Male Wistar rats were studied under a normal sodium intake (NS, NaCl 0.24%) or a high sodium intake (HS, NaCl 1% in drinking water) during the 5 days of the study. For the last two days, the specific D1‐like receptor antagonist SCH 23390 (1 mg kg bwt−1 day−1, sc) or a vehicle was administered. HS intake increased natriuresis, diuresis, and urinary DA while it decreased cortical NOS I expression (P < 0.05 vs. NS), Nicotinamide adenine dinucleotide phosphate diaphorase (NADPH‐d) activity in MD (P < 0.001 vs. NS) and cortical nitrates+nitrites (NOx) production (NS 2.04 ± 0.22 vs. HS 1.28 ± 0.10 nmol mg protein−1, P < 0.01). Treatment with SCH 23390 to rats on HS sharply decreased hydroelectrolyte excretion (P < 0.001 vs. HS) while NOS I expression, NADPH‐d activity and NOx production increased (P < 0.05 vs. HS for NOS I and P < 0.001 vs. HS for NADPH‐d and NOx). SCH 23390 increased RPF and GFR in HS rats (P < 0.01 HS+SCH vs. HS). It did not cause variations in NS rats. Results indicate that when NS intake is shifted to a prolonged high sodium intake, renal DA through the D1R, and NOS I in MD cells act in concert to regulate RPF and GFR to stabilize the delivery of NaCl to the distal nephron.
On the generalized orthogonal stability of the pexiderized quadratic functional equations in modular spaces
Authors: EL-Fassi Iz-iddine , Kabbaj Samir 
Published: March 2017

Abstract
In this paper, we establish the Hyers-Ulam-Rassias stability of the quadratic functional equation of Pexiderized type f(x + y)+ f(x - y) = 2g(x)+ 2h(y), x⊥y in which ⊥ is the orthogonality in the sense of Rätz in modular spaces.
Least absolute deviations problem for the Michaelis-Menten function
Authors: Sabo Kristian 
Published: March 2017

Abstract
In this paper, we consider the problem of the existence of a least absolute deviations estimator for the Michaelis-Menten model function. We give necessary and sufficient conditions under which the least absolute deviations problem has a solution. In order to illustrate the usefulness of such conditions we give several numerical examples.
Crystal structure of 2-(4-fluorophenyl)-1,3-dimethyl-1H-perimidin-3-ium iodide, C19H16FIN2
Authors: Li Zhong-Yan , Zhang Min , Yuan Xian-You , Yuan Lin 
Published: March 2017

Abstract
C19H16FIN2, orthorhombic, Pbca (no. 61), a = 15.1714(3) Å, b = 14.0610(3) Å, c = 15.9365(3) Å, V = 3399.65(12) Å3, Z = 8, R
gt(F) = 0.0295, wR
ref(F
2) = 0.0787, T = 296(2) K.
Syntaxerwerb bei ein- und mehrsprachigen Grundschüler/innen: eine quantitative Untersuchung
Authors: Goschler Juliana 
Published: March 2017

Abstract
In the German education system, a relatively strong connection between immigration background and educational success has repeatedly been observed. It is often assumed that this is due at least partly to differences in linguistic competence in German between mono- and bilingual children. However, results from international studies on language acquisition do not suggest a correlation between bilingualism and linguistic deficits, or delays in the development of linguistic competence. It seems necessary, therefore, to take a closer look at the linguistic development of mono- and bilingual children in specific cultural and educational settings. In this paper, I am going to present two studies conducted on the basis of 264 written narratives by third-graders in a small German town. The results of the first study show no significant difference in syntactic complexity between the texts of mono- and bilingual children. The second study shows small but significant differences in the number of grammatical errors, but not in the domain of syntax. Thus, differences in educational success are not due to an incomplete or delayed acquisition of syntactic structures.
Ferruccio Busoni and the “Halfness” of Frédéric Chopin
Authors: Knyt Erinn E. 
Published: March 2017

Ferruccio Busoni (1866–1924) championed Frédéric Chopin’s music. Yet his performances often elicited responses of shock or amusement because they rebelled against the prevalent sentimental style of interpretation associated with an “effeminate” Chopin. Even some of his staunchest admirers had trouble appreciating his unprompted repeats of measures or structural wholes in the preludes or etudes, his registral alterations, and his overly intellectualized approach. Also unusual was his choice to program the preludes as a complete cycle.
Scholars have documented Busoni’s interpretive eccentricities, but the rationale behind them and their significance for the evolution of Chopin interpretation in the twentieth century remains largely unexplored. Through analyses of recordings, concert programs, recital reviews, and Busoni’s little-known and unpublished essay from 1908 titled “Chopin: Eine Ansicht über ihn,” I connect Busoni’s unconventional Chopin interpretations to an idiosyncratic perception of Chopin’s character. In the nineteenth century Chopin and his music were commonly viewed as effeminate, androgynous, childish, sickly, and “ethnically other.” Busoni’s essay indicates that he, too, considered Chopin’s music “poetic,” “feminine,” and “emotive.” But this was problematic for Busoni, who was obsessed with “manliness” in an age in which gender roles were gradually changing. He discovered “half-manly” and “half-dramatic” elements in the music and in Chopin’s character—that is, a heroic, monumental side. In striving to portray the “whole” of Chopin and his music while distancing himself from the gendered “halfness” of earlier writings, Busoni became a pioneer of bolder Chopin interpretation and of monumentalist programming. His portrait of Chopin reveals how cultural ideas inform the evolution of performers’ interpretations.
POLA PENDIDIKAN NABI YA’QUB A.S. DALAM MENDIDIK NABI YUSUF A.S. PERSPEKTIF AL-QUR’AN
Authors: Thobroni Ahmad Yusam 
Published: March 2017

<p>Metode pengajaran yang tergambar dalam kisah Nabi Ya’qub dan Nabi Yusuf berupa dialog interaktif yang memberikan panduan akan aksi pendidik dan reaksi anak didik. Sedangkan kompetensi pendidik dan etika anak didik dapat dijelaskan sebagai sikap-sikap yang mesti dimiliki oleh komunitas pendidikan; seperti kesabaran, menjaga rahasia, mengembangan bakat secara individual, melihat kondisi sosial terlebih dahulu jika akan menyampaikan sesuatu, mentakwilan mimpi, kasih sayang, mampu memanfaatkan situasi, mudah memaafkan, mendoakan pihak lain, serta bersikap pasrah dan tunduk. Sebagai pendidik dan anak didik, jika mampu menerapkan pola pendidikan seperti digambarkan di atas, maka insyaallah akan terlahirkan generasi yang baik, unggul dan kompetitif karena terlahir dari pola pendidikan Qur’ani.</p>
Labmagengeschwüre beim Rind
Authors: Wittek T. , Hund A. 
Published: March 2017

ZusammenfassungLabmagengeschwüre beim Rind sind in mehrerlei Hinsicht problematisch. Sie verursachen durch Schmerzen Leistungseinbußen und können gravierende Folgen bis hin zum Tod des Tieres haben. Meist lassen sie sich nur schwer diagnostizieren, weshalb die Angaben zur Prävalenz stark schwanken. Zudem gibt es nur limitierte Behandlungsmöglichkeiten. Die Ulzera werden in vier Typen eingeteilt: Labmagengeschwüre von Typ 1 sind oberflächliche, nicht perforierende Läsionen, bei Typ-2-Läsionen kommt es durch die Arrosion eines größeren Blutgefäßes in der Labmagenwand zu starkem Blutverlust und bei Typ 3 sowie 4 handelt es sich um perforierende Ulzera mit lokaler bzw. diffuser Peritonitis. Labmagengeschwüre haben eine multifaktorielle Genese. Sie entstehen unter anderem durch falsche Fütterung und damit einhergehende Verdauungsstörungen, als Nebenwirkung von Medikamenten wie nichtsteroidale Antiphlogistika und als Folge anderer Erkrankungen. Prinzipiell liegt pathophysiologisch eine stressbedingte Störung der protektiven Mechanismen im Labmagen vor. Die klinischen Symptome sind mannigfaltig und meist unspezifisch. Die Untersuchung auf okkultes Blut im Kot, Blutbild und blutchemische Para meter, eine Ultraschalluntersuchung oder Abdominozentese können Hinweise auf die Diagnose liefern. Die therapeutischen Optionen umfassen eine symptomatische, chirurgische und medikamentöse Behandlung. Zu den Präventionsmaßnahmen gehören eine adäquate Fütterung und Haltung der Tiere sowie die möglichst frühzeitige Diagnose und Behandlung von Erkrankungen, die die Bildung von Labmagengeschwüren zur Folge haben könnten. Belastungssituationen wie Transport und Gruppenwechsel sollten vermieden werden.
LiÃ§Ãµes da AmÃ©rica: o problema do americanismo em Tocqueville
Authors: Vianna Luiz Werneck 
Published: March 2017

Quem deve prestar liÃ§Ãµes a quem: a AmÃ©rica Ã Europa ou vice-versa? O autor interpreta o pensamento de Tocqueville Ã luz dessa questÃ£o, trabalhando com o conceito de americanismo - isto Ã©, a conciliaÃ§Ã£o que se tornou possÃvel nos Estados Unidos, sem que rupturas revolucionÃ¡rias ocorressem, entre estado social de igualdade e liberdade, entre interesse e virtude, entre privado e pÃºblico. Ã‰ essa conciliaÃ§Ã£o, argumenta o autor, que Tocqueville, atento para a irresistÃvel igualizaÃ§Ã£o das condiÃ§Ãµes de vida na Europa, viu na experiÃªncia norte-americana.
Orígenes del terrorismo global: una propuesta de análisis
Authors: Zarrouk Mourad 
Published: March 2017

El presente artículo pretende analizar las causas lejanas del terrorismo procedente de países islámicos. Los orígenes del terrorismo global de hoy en día están bien anclados en la guerra contra la ex Unión Soviética que se desarrolló en tierras afganas. La gestión de la posguerra por los diferentes actores políticos involucrados en el conflicto contribuyó en la consolidación del yihadismo que se propagó aprovechando el vacío político y el abandono de Afganistán después de la guerra. Por otra parte, la represión del islamismo moderado en los países árabes provocó un proceso de radicalización que se alimentaba directamente de un discurso violento que vino a sustituir el discurso tradicional del islam político. La gestión del campo religioso por los regímenes de los países árabes e islámicos no aportó ninguna solución al problema del radicalismo, pues los ulemas oficiales no estaban capacitados para contrarrestar el avance del extremismo ni para sustituir a un actor político importante como los islamistas, cuyo discurso necesita actualmente una reforma profunda.