bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naloxone Dispensing to Youth Ages 10–19: 2017–2022
Authors: Terranella Andrew , Guy Gery , Mikosz Christina 
Published: September 2024

BACKGROUND AND OBJECTIVES
Naloxone is lifesaving in the event of an opioid overdose but is underutilized in adolescents. Youth-serving clinicians can play a role in expanding naloxone access by offering it to all youth at risk for opioid-involved overdose, including by prescription. Understanding naloxone dispensing trends to youth can inform efforts to expand its use.

METHODS
We used IQVIA National Prescription Audit Patient Insights data, which contains prescriptions dispensed from ∽48 900 retail pharmacies, representing 93% of all prescriptions from all payers in the United States. Cross-sectional analyses were used to describe naloxone dispensing trends among youth ages 10 to 19 years over time and by patient sex, out-of-pocket cost, prescriber specialty, and payer.

RESULTS
From 2017 to 2022, 59 077 prescriptions for naloxone were dispensed to youth ages 10 to 19. Dispensing rates increased 669%, from 6.6 to 50.9 prescriptions per 100 000 adolescents, with increases each year. Dispensing varied by specialty and sex. Pediatricians accounted for an increasing proportion of prescriptions dispensed with a 6-year increase of 991%. Seventy-four percent of prescriptions were paid through commercial insurance. Although most prescriptions dispensed had low to 0 cost-sharing, 20% had out-of-pocket costs exceeding $25, and over 6% had out-of-pocket costs exceeding $75.

CONCLUSIONS
Pediatricians and other youth-serving clinicians can play an important role in expanding access to naloxone and harm reduction information by prescribing naloxone to all youth who are at risk for overdose. Clinician prescribing of naloxone can augment community distribution and over-the-counter access by making naloxone more widely available at all touchpoints with the health care system.
КОНЦЕПТ «ЖІНКА» У МОВНІЙ СВІДОМОСТІ СУЧАСНОЇ МОЛОДІ
Authors: Корольова В. 
Published: September 2024

Постановка проблеми. Концепт «жінка» є базовим концептом української культури, складником ядра мовної свідомості, який відбиває її специфіку. Серед особливостей, що характеризують концепт, лінгвісти виокремлюють такі: концепт завжди має мовну вербалізацію; концепт «належить» усім представникам тієї чи тієї лінгвокультури; структуру концепту складають інформаційний, оцінний та асоціативний компоненти. Актуальним аспектом гендерології є реструктуризація гендерно маркованих концептів через зміни в мовній свідомості.
Метою статті є аналіз характеристик концепту «жінка», зафіксованого через асоціативний експеримент. Поставлена мета передбачає виконання таких завдань: зробити статистичний аналіз асоціативних характеристик, виділити ядерні асоціативні ознаки досліджуваного концепту, порівняти ядра асоціативних полів у різногендерних групах респондентів, виявити стереотипізований асоціативний шлейф концепту «жінка».
Методи дослідження. До методів нашої статті залучаємо методи дефінітивного та компонентного аналізу, описовий метод з використанням прийомів інтерпретації, зіставлення й узагальнення, статистичний метод для наповнення концептосфери та побудови репрезентативної вибірки дослідження, асоціативний експеримент як засіб отримання інформації про мовну свідомість.
Основні результати дослідження. Гендерний концепт «жінка» вважаємо багатомірними культурно-значущими соціопсихологічними утвореннями в колективній свідомості, опредметненими в мовній формі. Реакції, отримані під час вільного асоціативного експерименту, структурують асоціативне поле концептів з ядром і периферією. За результатами опитування асоціативний портрет жінки для фемінної аудиторії можемо узагальнити так: «краса», «роль матері», «розум», «сила», «самостійність», «турботливість». Для маскулінної групи лексема «жінка» передусім асоційована з поняттями «краса», «мати» «кохання», «доброта». Відкриті питання запопонованого асоціативного експерименту засвідчили слабку наявність гендерних стереотипів у мисленні сучасної молоді. Отже, гендерні стереотипи, незважаючи на достатню стійкість і поступовість змін протягом значного періоду життя, зазнають трансформації в мовній свідомості сучасної молоді. Це засвідчує певна бінарність відповідей на пропоновані запитання, за якими протиставлено ядерні ознаки концепту «жінка», а саме врода і цілеспрямованість.
Висновки і перспективи. Реконструюючи досліджуваний асоціативний портрет, зазначимо, що для концепту «жінка» домінантною ознакою є «врода», що зумовлено впливом штампів, стереотипів, за якими складаються традиційні уявлення про типові жіночі риси. Перспективою подальших розвідок вважаємо аналіз особливостей мовного вираження гендерних концептів у різних типах сучасних дискурсів.
Evaluación técnica de la eficacia de productos curadores como opción al curado húmedo del concreto
Authors: Rojas Einer Rodríguez , Muñoz Umaña Flor de María , Sandoval González José David 
Published: September 2024

Esta investigación tiene como objetivo determinar los efectos del uso de productos curadores en el concreto hidráulico mediante condiciones de laboratorio. No obstante que investigaciones y especificaciones técnicas de los productos curadores indican mejoras en el curado del concreto, su utilización y posibles ventajas deben ser experimentalmente verificadas para las condiciones y tipos de concretos fabricados en Costa Rica. Se utilizan tres tipos de productos curadores, el primero corresponde a un producto curador transparente a base de silicatos que no produce membrada (C1), el segundo es un producto curador formador de membrana a base de resinas (C2) y el tercero es un producto curador formador de película a base de solución coloidal (C3). Por medio de ensayos de laboratorio se determina la resistencia a la compresión, módulo de ruptura y cambio de longitud (expansión o contracción) del concreto para diferentes condiciones de curado. En general, los resultados indican que los productos curadores, a cualquier edad de aplicación, no disminuyen la contracción o expansión del concreto. Para que los curadores logren una efectividad adecuada en el desarrollo de la resistencia a la contracción y a la flexión en el concreto, se debe curar con agua por un mínimo de tres días previo a la aplicación del producto. Los resultados sugieren mejores resultados al aplicar el producto curador a los 7 días luego de mantener los especímenes en el cuarto húmedo.
Estudio R&R de frecuencias naturales en madera de S. campanulata, F. americana y A. Plurijuga.
Authors: Sotomayor-Castellanos Javier-Ramón , Sosa Villanueva Héctor Manuel 
Published: September 2024

El objetivo de la investigación fue realizar un estudio de repetibilidad y reproducibilidad en muestras representativas de probetas de madera de pequeñas dimensiones de Spathodea campanulata, Fraxinus americana y Albizia Plurijuga. La estrategia experimental asume dos etapas. La primera consistió en el análisis de los resultados de las frecuencias medidas en las tres especies angiospermas. Su objetivo fue validar la homogeneidad y la representatividad de las maderas en estudio. La segunda etapa se orientó al estudio de las variaciones de los resultados de las frecuencias. Su objetivo fue construir tablas de repetibilidad y reproducibilidad y de su análisis de varianza. Se preparó un diseño completamente al azar y balanceado. La unidad experimental consistió en tres grupos homogéneos de 40 probetas de cada especie. Para cada especie estudiada se realizaron estudios cruzados de repetibilidad y reproducibilidad. Los resultados indican que para S. campanulata, el 97,7% de la varianza total se debe al instrumento en tanto que el 2,3% a diferencias entre operadores; para F. americana, el 99,2% de la varianza total se debe al instrumento y el 0,8% a diferencias entre operadores, mientras que para A. plurijuga, el 100% de la varianza total se debe al instrumento en tanto que no existe variabilidad debida a diferencias entre operadores.
Analysis of B cell proliferation in response to in vitro stimulation in patients with CVID
Authors: Velásquez-Ortiz Ma. Guadalupe Velásquez-Ortiz , Saldaña-Solano Abigail J. , O’Farrill-Romanillos Patricia , Herrera-Sánchez Diana Andrea , Scheffer-Mendoza Selma , Yamazaki-Nakashimada Marco A. , Zarate-Hernández Ma. Carmen , Espinosa-Padilla Sara E. , Berrón-Ruiz Laura 
Published: September 2024

Background: Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by defective antibody production and impaired differentiation of B cells. B cell proliferation is an essential step for antibody synthesis. Depending on the nature of the stimulus, their response may be either T-cell-dependent or T-cell-independent.
Methods: We studied 23 CVID patients and 14 healthy donors (HD). The patients were categorized based on their percentage of memory B cells. In addition to standard immunophenotyping of circulating human B and T cell subsets, an in vitro CFSE dilution assay was used to assess the proliferative capacity of B cells and to compare the activation of the T cell-dependent and T cell-independent response among the patients.
Results: Patients with a reduction in memory B cells exhibited an increase in follicular T cells (Tfh) and showed low proliferation in response to PKW, CpG, and SAC stimuli (Condition II) (p= 0.0073). In contrast, patients with a normal percentage of memory B cells showed a high expression of IL-21R and low proliferation in response to CPG (Condition III); IL-21, CD40L, and anti-IgM (Condition IV) stimuli (p= 0.0163 and p = 0.0475, respectively).
Conclusion: Defective proliferation in patients depends on the type of stimulus used and the phenotypic characteristics of the patients. Further studies are necessary to understand the disease mechanisms, which may guide us toward identifying genetic defects associated with CVID.
Comparative Analysis of the Effectiveness of Riskometer Scales in Predicting the Risk of in-Hospital Mortality in Patients With ST-Segment Elevation Myocardial Infarction After Percutaneous Coronary Intervention
Authors: Geltser B. I. , Shahgeldyan K. I. , Domzhalov I. G. , Kuksin N. S. , Kotelnikov V. N. , Kokarev E. A. 
Published: September 2024

Aim. Comparative evaluation of the effectiveness of riskometer scales in predicting in-hospital death (IHD) in patients with ST-segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI) and the development of new models based on machine learning methods.Material and methods. A single-center cohort retrospective study was conducted using data from 4,675 electronic medical records of patients with STEMI (3,202 men and 1,473 women) with a median age of 63 years who underwent emergency PCI. Two groups of patients were isolated: group 1 included 318 (6.8%) patients who died in hospital; group 2 consisted of 4,359 (93.2%) patients with a favorable outcome. The GRACE, CADILLAC, TIMI-STe, PAMI, and RECORD scales were used to assess the risk of IHD. Prognostic models of IHD predicted by the sums of these scale scores were developed using single- and multivariate logistic regression, stochastic gradient boosting, and artificial neural networks (ANN). Risk of adverse events was stratified based on the ANN model data by calculating the median values of predicted probabilities of IHD in the compared groups.Results. Comparative analysis of the prognostic value of individual scales for the STEMI patients showed differences in the quality of the risk stratification for IHD after PCI. The GRACE scale had the highest prognostic accuracy, while the PAMI scale had the lowest accuracy. The CADILLAC and TIMI-STe scales had acceptable and comparable prognostic abilities, while the RECORD scale showed a significant proportion of false-positive results. The integrative ANN model, the predictors of which were the scores of 5 scales, was superior in the prediction accuracy to the algorithms of single- and multivariate logistic regression and stochastic gradient boosting. Based on the ANN model data, the probability of IHD was stratified into low (<0.3%), medium (0.3-9%), high (9-17%), and very high (>17%) risk groups.Conclusion. The GRACE, CADILLAC and TIMI-STe scales have advantages in the stratification accuracy of IHD risk in patients with STEMI after PCI compared to the PAMI and RECORD scales. The integrated ANN model that combines the prognostic resource of the five analyzed scales, had better quality criteria, and the stratification algorithm based on the data of this model was characterized by accurate identification of STEMI patients with high and very high risk of IHD after PCI.
Clear cell adenocarcinoma with hepatoid differentiation of gallbladder: An unique histopathological type: Case with review of literature
Authors: Jagtap Sunil Vitthalrao , Borade Devika S , Jagtap Shubham S , Ghadge Neha , Hulwan Atul B 
Published: September 2024

The clear-cell variant of gallbladder is exceedingly rare tumor. A 56 year male patient presented with complaints of pain in the right upper quadrant of abdomen with vomiting, anorexia, weight loss. On radio imaging ultrasonography, computed tomography and magnetic resonance cholangiopancreatography abdomen- pelvis reveals a 2 x 2 cm gallbladder mass. Tumor was extending in adjacent segment 5 of liver and lymph nodes. Features were in favors of carcinoma of the gall bladder with liver extension and regional lymph nodal metastasis. Patient underwent an open cholecystectomy with lymph nodes resection. On histopathological findings we reported as clear cell adenocarcinoma with Hepatoid differentiation of gallbladder. We are presenting rare case of moderately differentiated clear cell adenocarcinoma with Hepatoid differentiation of gallbladder with aggressive biologic behavior for its clinical, radiological, histopathological findings and review.
Autoclítico na proposta de B. F. Skinner para o Comportamento Verbal
Authors: Spatafora Gabriel , Micheletto Nilza 
Published: September 2024

Skinner (1992) realizou uma classificação do comportamento verbal, propondo operantes primários (mando, tato, ecoico, intraverbal, textual, transcrição) e indicou o autoclítico como secundário. Segundo Skinner, o autoclítico teria a função de modificar o efeito dos operantes primários, tornando-os mais efetivos na alteração do comportamento do ouvinte, conforme especificidades da interação, ocorrendo obrigatoriamente em conjunto com a composição, que envolveria a emissão de respostas verbais novas. O presente trabalho teve como objetivo apresentar aspectos centrais da definição do autoclítico e as classificações em diferentes tipos, proposta no livro Comportamento Verbal. Apresentamos aspectos indicados por Skinner para definir o conceito e descrições e classificações dos autoclíticos em diferentes tipos: descritivo, qualificativo, quantitativo e relacional. Destacamos a distinção de parâmetros da classificação de Skinner; para os operantes primários a classificação é feita por meio da análise da estimulação antecedente e consequente, para cada tipo de autoclítico é classificado em relação à maneira pela qual modifica ou especifica o efeito do operante primário. A partir das análises, evidencia-se a necessidade de ampliação de investigações teóricas, básicas e aplicadas sobre o comportamento autoclítico tanto em relação ao esclarecimento do conceito, como sobre variáveis que favorecem a aquisição do autoclítico, como das formas de controle que permitem que ele altere os operantes primários. Palavras-chave: autoclítico, gramática, composição, análise do comportamento, comportamento verbal.
Enhancing Management Research through Qualitative Methods
Authors: Balbastre-Benavent Francisco , Duque-Oliva Edison Jair , Canet-Giner María Teresa 
Published: September 2024

Considering the changes and uncertainties of the current environment that affect management in organizations, the use of qualitative methods in business research facilitates the study of organizational phenomena from a different perspective while acknowledging their complexity. The objective of this special issue is to offer greater exposure to empirical studies that thoroughly employ qualitative methods to solving business and management problems. We have attempted to showcase how diverse Qualitative methodologies, from classic case-based strategies to more novel ones such as action research, provide new visions for approaching the study of organizational realities. Also, we have briefly reflected on the application of new tools as visual techniques or AI to business and management research. Therefore, this special issue offers five papers that, from different methodological perspectives and content, seek to contribute to this objective. We hope that this special issue represents a significant advancement in the visibility and appreciation of qualitative methods within the field of business and management research.
In-Home IBCLC Care and Duration of Breastfeeding: A Mixed Methods Study
Authors: Wessells Allyson , Gallagher Megan , Oberholzer Julie , Rice Heather 
Published: September 2024

Objective:IBCLC care is among the recommendations to improve breastfeeding duration. IBCLC care may occur in hospitals, pediatric clinics, obstetrics and gynecology clinics, and home settings. Insurance coverage for this care is intended to be protected per the Affordable Care Act in the United States. The aim of this study was to analyze the 12-month breastfeeding duration outcomes after receiving in-home IBCLC care within the first year of birth.Methods:Anonymous responses to surveys completed at least 1 year after care initiation with a private practice located in Columbus, Ohio, were collected for a 3-year period. The survey consisted of 20 items answered by 113 respondents and provided qualitative and quantitative data. A mixed-method design was used for analysis of data with descriptive statistics regarding number of visits, infant age at initiation of care, insurance coverage, breastfeeding goals, confidence before and after services, and duration of any breastfeeding. Qualitative comments were reviewed for consistent themes.Results:The majority (58%) of respondents had three or fewer visits, infants less than 4 weeks old (72%), and goals to breastfeed for at least 6 months (90%). Insurance coverage was provided for most respondents (81%). Confidence levels of less than 50% prior to services were reported by most respondents (73%) and increased to greater than 80% among the majority of respondents (78%) after services. Improved breastfeeding duration rates to 6 months (90%) and 12 months (73%) were achieved by most respondents compared to national rates of 55.8% and 35.9%. Consistent themes included continuity of IBCLC care, in-home setting, insurance coverage, care quality, and confidence.Conclusions:In-home IBCLC care can efficiently improve breastfeeding duration and confidence. Insurance coverage may facilitate outcomes that reduce the risks of not breastfeeding.
PENDAYAGUNAAN LIMBAH DIAPER SEBAGAI BAHAN BAKAR MENGGUNAKAN PROSES DENSIFIKASI
Authors: Muyasaroh Nurul , Ayuningtyas Endah 
Published: September 2024

Popok sekali pakai (diaper) menjadi pilihan mayoritas ibu karena kepraktisannya. Hal ini menimbulkan limbah diaper yang semakin hari semakin menumpuk. Pendayagunaan limbah diaper masih sangat jarang dilakukan. Selama ini limbah diaper ditimbun di tempat pembuangan sampah atau dibuang sembarangan di sungai. Kondisi ini menimbulkan dampak negatif terhadap lingkungan, baik berupa pencemaran udara, air, tanah serta berkurangnya estetika lingkungan. Terlebih jika terdapat feses pada limbah diaper sehingga menimbulkan pencemaran bakteri Escherichia coli. Penelitian ini bertujuan untuk mengolah limbah diaper menjadi biofuel pellet yang renewable dan sustainable menggunakan proses densifikasi. Tujuan selanjutnya dari penelitian ini adalah untuk mengetahui pengaruh kelembaban terhadap nilai kalor biofuel pellet, menganalisis proksimat serta membandingan angka Escherichia coli limbah diaper sebelum dan sesudah diolah menjadi biofuel pellet. Proses pembuatan biofuel pellet dilakukan dengan mengumpulkan limbah diaper; menghancurkannya menggunakan alat pencacah; mengeringkan dan mensterilkannya; kemudian mencetak menjadi biofuel pellet. Pengujian nilai kalor dilakukan berdasarkan pedoman ASTM D-2015 dan perhitungannya berdasarkan pedoman ASTM D-3175. Analisis proksimat dilakukan berdasarkan pedoman ASTM D-3174, ASTM D-1762-84, ASTM D-3172 dan ASTM D-2395. Limbah diaper dapat diolah menjadi biofuel pellet menggunakan proses densifikasi. Semakin rendah kelembaban, maka nilai kalor biofuel pellet semakin tinggi. Biofuel pellet dengan kelembaban 0% memiliki nilai kalor sebesar 6181,9 kal/g, kadar zat volatil 74,55%, kadar abu sebesar 15,25%, kadar karbon terikat sebesar 10,20% dan densitas sebesar 0,86 . Nilai kalor, kadar zat volatil dan densitas biofuel pellet ini memenuhi standar SNI 8021:2014. Sedangkan kadar abu dan kadar karbon terikat belum memenuhi standar. Angka Escherichia coli limbah diaper sebesar cfu/g, sedangkan setelah diolah menjadi biofuel pellet menurun drastis yaitu <10 cfu/g.
Thirty-five Years of Reporting of Sex and Race in Clinical Studies of U.S. FDA-Authorized Orthopaedic Devices
Authors: Jiang Hongying , Kavlock Katherine , Li Qin , Mistry Shruti , Hermes Valerie , Gibbs Alonza , Adegboyega-Panox Elizabeth , Peat Raquel 
Published: September 2024

Background:
At the U.S. Food and Drug Administration (FDA), the mission of the Center for Devices and Radiological Health (CDRH) is to ensure that all patients and providers have timely and continued access to safe, effective, and high-quality medical devices and safe radiation-emitting products. Although the CDRH has observed enrollment differences in some clinical trials, no systematic analysis has been conducted regarding enrollment differences in baseline demographics, to our knowledge.

Methods:
The CDRH has summarized information on study participants and their baseline demographics in public-facing documentation for all authorized medical devices that involved orthopaedic clinical studies from 1985 to 2020. Descriptive analyses and exploratory statistical testing have been conducted to investigate the reported percentages by sex and race compared with those reported in the U.S. National Census and the American Joint Replacement Registry (AJRR), respectively.

Results:
We identified 94 submissions and corresponding combined clinical trials from 261 original clinical study arms with 34,193 participants. Most of the submissions reported age and sex, while only 36 submissions (38.3%) reported racial demographics. Among the 88 trials providing enrollment by sex, the female enrollment percentage ranged from 22.2% to 88.7%, with a mean of 55.0%. In the submissions that reported racial data (38.3%), White and Black patients had a mean enrollment of 89.2% (range, 64.8% to 98.7%) and 6.2% (range, 0.4% to 20.7%), respectively. The enrollment for other minority groups ranged from 0% to 3.0%. These clinical trials have shown numerically lower female representation (55.0%) but higher White representation (89.2%) than what has been reported in the AJRR. The other racial groups have participated much less than their corresponding percentages in the U.S. population, but they are similarly represented in the AJRR.

Conclusions:
The clinical trials supporting the FDA’s authorization of orthopaedic devices had a wide range of sex and racial enrollments. It appears that female enrollment mirrors the percentage of women in the U.S. population. However, despite prior efforts, some racial groups are still underrepresented. The FDA has made a commitment to advancing health equity as part of the 2022-2025 Strategic Priorities of the CDRH. We hope that the results of this study will help health-care professionals make informed clinical decisions when using medical devices.