bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound-based grading of carpal tunnel syndrome: a comparative study of cross-sectional area and shear wave elastography at different wrist joint angles
Authors: Zou Qijiu , Guo Xiaoli , Ni Xuejun , Chen Xiaoyang , Xu Cheng , Yin Yifei , Huang Chen 
Published: September 2024

Abstract

Objectives
Carpal tunnel syndrome (CTS) is a prevalent neuropathy where accurate diagnosis is crucial for effective treatment planning. This study introduces a novel approach for CTS grading using ultrasound, specifically through the analysis of the cross-sectional area (CSA) and shear wave elastography (SWE) of the median nerve in various wrist positions.

Methods
Our research involved subjects from outpatient clinics, diagnosed with CTS through nerve conduction studies (NCS), and a control group of healthy individuals. High-frequency ultrasound and SWE measurements were conducted in 3 wrist positions: straight, 45° extension, and 45° flexion.

Results
The key findings revealed significant differences in median nerve CSA and SWE values between the CTS and control groups across all wrist positions, with notable variances in SWE values correlating with wrist positioning. SWE demonstrated enhanced sensitivity and specificity in distinguishing between mild, moderate, and severe CTS, especially at 45° wrist flexion. In contrast, CSA measurements were limited in differentiating between the varying severity stages of CTS.

Conclusions
The study concludes that SWE, particularly at 45° wrist flexion, provides a more precise diagnostic benchmark for CTS severity grading than CSA. This advancement in non-invasive diagnostic methodology not only aids in accurate CTS grading but also has significant implications in formulating tailored treatment strategies, potentially reducing the reliance on more invasive diagnostic methods like NCS.

Advances in knowledge
This study marks a significant advancement in the ultrasound diagnosis of CTS. It particularly highlights the importance of applying SWE technology across various wrist joint angles, offering a new diagnostic benchmark. This discovery provides data support and additional insights for achieving an early consensus on ultrasound-based grading diagnosis of CTS.
Risk factor-targeted abdominal aortic aneurysm screening: systematic review of risk prediction for abdominal aortic aneurysm
Authors: Musto Liam , Smith Aiden , Pepper Coral , Bujkiewicz Sylwia , Bown Matthew 
Published: September 2024

Abstract

Background
This systematic review aimed to investigate the current state of risk prediction for abdominal aortic aneurysm in the literature, identifying and comparing published models and describing their performance and applicability to a population-based targeted screening strategy.

Methods
Electronic databases MEDLINE (via Ovid), Embase (via Ovid), MedRxiv, Web of Science, and the Cochrane Library were searched for papers reporting or validating risk prediction models for abdominal aortic aneurysm. Studies were included only if they were developed on a cohort or study group derived from the general population and used multiple variables with at least one modifiable risk factor. Risk of bias was assessed using the Prediction model Risk Of Bias ASsessment Tool. A synthesis and comparison of the identified models was undertaken.

Results
The search identified 4813 articles. After full-text review, 37 prediction models were identified, of which 4 were unique predictive models that were reported in full. Applicability was poor when considering targeted screening strategies using electronic health record-based populations. Common risk factors used for the predictive models were explored across all 37 models; the most common risk factors in predictive models for abdominal aortic aneurysm were: age, sex, biometrics (such as height, weight, or BMI), smoking, hypertension, hypercholesterolaemia, and history of heart disease. Few models had undergone standardized model development, adequate external validation, or impact evaluation.

Conclusion
This study identified four risk models that can be replicated and used to predict abdominal aortic aneurysm with acceptable levels of discrimination. None of the models have been validated externally.
Efficient object detector via dynamic prior and dynamic feature fusion
Authors: Zhang Zihang , Liu Yuling , Zhou Zhili , Yang Gaobo , Wu Q M Jonathan 
Published: September 2024

Abstract
Sparse R-CNN is a new paradigm of object detection, which predicts objects in a sparse way. However, there are some limitations in Sparse R-CNN. One is the presence of weak prior information caused by fixed learnable proposal boxes and features across different images, necessitating excessive iterations for the model to refine its predictions; the other is the inadequate exploitation of multi-scale information, leading to the sub-optimal detection performance. Thus, building upon Sparse R-CNN, we propose an efficient detector that incorporates dynamic prior and dynamic feature fusion, called $D^{2}$-Det. In particular, for the dynamic prior part, a prior information generator module dynamically generates proposal features and boxes as the dynamic prior for different images to alleviate the inference-inefficient iterative refinement process of predictions, and we further propose the class scores decoupling method to reduce the computation overhead. Furthermore, for the dynamic feature fusion part, we develop a novel lightweight multi-scale feature fusion module, which dynamically aggregates features from all layers for each proposal box, enabling adaptive feature fusion and improving detection precision by nearly 2 AP. Experiments show that $D^{2}$-Det can achieve 46.6 AP on COCO 2017 with fewer computations for the backbone ResNet50, surpassing most of the state-of-the-art detectors.
Intrusion detection based on hybrid metaheuristic feature selection
Authors: Zhang Fengjun , Huang Lisheng , Shi Kai , Zhai Shengjie , Lan Yunhai , Li Qinghua 
Published: September 2024

Abstract
The multidimensional features of network flows are the main data source for intrusion detection, but excessively low-value features generate accuracy and efficiency challenges. Researchers have used redundant feature reduction to simplify intrusion detections, and feature selection algorithms are beginning to be widely used. This paper presents a novel hybrid feature selection algorithm, CSA-FPA, which combines both a crow search algorithm and a flower pollination algorithm. In this method, properties such as local pollination and the levy flight of FPA are used to balance the global search and local search efficiencies, and parameters such as group distance and probability thresholds are introduced to customize the model’s appearance. The simulation results on the UNSW-NB15 and CIC-IDS2017 datasets show that the proposed CSA-FPA method achieves better detection accuracies than previous algorithms. Using the proposed feature selection method, the AdaBoost classifier achieved a detection accuracy of 99.14% on the CIC-IDS2017 dataset and 97.98% on the UNSW-NB15 dataset.
Review: Risk Stratification of Patients With Ulcerative Colitis for Treatment With Tofacitinib
Authors: Danese Silvio , Panés Julian , Dubinsky Marla , Guo Xiang , Yndestad Arne , Schreiber Stefan , Chaparro María 
Published: September 2024

Lay Summary
Higher age (65 years or over), long-term smoking, or a previous cardiovascular event (such as heart attack) should be considered safety risks when considering treatment with tofacitinib versus tumor necrosis factor inhibitors for people with ulcerative colitis.
Activation of β3-adrenergic receptor by mirabegron prevents aortic dissection/aneurysm by promoting lymphangiogenesis in perivascular adipose tissue
Authors: Zhang Ze-Bei , Cheng Yu-Wen , Xu Lian , Li Jia-Qi , Pan Xin , Zhu Min , Chen Xiao-Hui , Sun Ai-Jun , Lin Jing-Rong , Gao Ping-Jin 
Published: September 2024

Abstract

Aims
β3-Adrenergic receptor (β3-AR) is essential for cardiovascular homoeostasis through regulating adipose tissue function. Perivascular adipose tissue (PVAT) has been implicated in the pathogenesis of aortic dissection and aneurysm (AD/AA). Here, we aim to investigate β3-AR activation-mediated PVAT function in AD/AA.

Methods and results
Aortas from patients with thoracic aortic dissection (TAD) were collected to detect β3-AR expression in PVAT. ApoE−/− and β-aminopropionitrile monofumarate (BAPN)-treated C57BL/6 mice were induced with Angiotensin II (AngII) to simulate AD/AA and subsequently received either placebo or mirabegron, a β3-AR agonist. The results demonstrated an up-regulation of β3-AR in PVAT of TAD patients and AD/AA mice. Moreover, activation of β3-AR by mirabegron significantly prevented AngII-induced AD/AA formation in mice. RNA-sequencing analysis of adipocytes from PVAT revealed a notable increase of the lymphangiogenic factor, vascular endothelial growth factor C (VEGF-C), in mirabegron-treated mice. Consistently, enhanced lymphangiogenesis was found in PVAT with mirabegron treatment. Mechanistically, the number of CD4+/CD8+ T cells and CD11c+ cells was reduced in PVAT but increased in adjacent draining lymph nodes of mirabegron-treated mice, indicating the improved draining and clearance of inflammatory cells in PVAT by lymphangiogenesis. Importantly, adipocyte-specific VEGF-C knockdown by the adeno-associated virus system restrained lymphangiogenesis and exacerbated inflammatory cell infiltration in PVAT, which ultimately abolished the protection of mirabegron on AD/AA. In addition, the conditional medium derived from mirabegron-treated adipocytes activated the proliferation and tube formation of LECs, which was abrogated by the silencing of VEGF-C in adipocytes.

Conclusion
Our findings illustrated the therapeutic potential of β3-AR activation by mirabegron on AD/AA, which promoted lymphangiogenesis by increasing adipocyte-derived VEGF-C and, therefore, ameliorated PVAT inflammation.
Dual-chamber leadless pacemaker in complex adult congenital heart disease: a case report
Authors: Ngan Ho Ting Abe , Fabbricatore Davide , Regan William , Rosenthal Eric , Wong Tom 
Published: September 2024

Abstract

Background
Atrioventricular block is common with adult congenital heart disease and pacemaker implantation is challenging. Atrioventricular synchronous pacing is important for better haemodynamics. This case reports the implantation of a dual-chamber leadless pacemaker in a patient with univentricular heart physiology and contributes to the literature regarding the management option in complex adult congenital heart disease patients with conduction abnormalities.

Case summary
A 25-year-old male with double inlet left ventricular, transposition of great arteries, hypoplastic aortic arch receive multiple surgeries including the Glenn shunt at the age of 1. He presented with 2:1 and 3:1 heart block at the age of 13 with a transvenous dual-chamber pacemaker implanted by pacing the superior vena cava stump and puncturing the Glenn shunt for the ventricular lead. A decade later, lead malfunctioned and the patient progressed to complete heart block. A subcutaneous implantable cardioverter defibrillator was implanted when he was 23 for monomorphic ventricular tachycardia. Given the anticipated challenges with transvenous lead extraction and epicardial pacemaker implantation, we implanted the novel dual-chamber leadless pacemakers which resulted in satisfactory atrioventricular synchronous pacing performance immediately post-op and 2 weeks after the procedure.

Discussion
We present a case of a novel dual-chamber leadless pacemaker implantation to maintain atrioventricular synchrony in the patient with complete heart block and univentricular physiology. This case illustrates an additional pacing option in complex adult congenital heart to maintain atrioventricular synchrony.
Diet and risk of atrial fibrillation: a systematic review
Authors: Gawałko Monika , Middeldorp Melissa E , Saljic Arnela , Penders John , Jespersen Thomas , Albert Christine M , Marcus Gregory M , Wong Christopher X , Sanders Prashanthan , Linz Dominik 
Published: September 2024

Abstract
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia. Comprehensive modification of established AF risk factors combined with dietary interventions and breaking deleterious habits has been shown to reduce AF burden and recurrence. Numerous AF risk factors, such as diabetes, obesity or hypertension can be partially related to dietary and lifestyle choices. Therefore, dietary interventions may have potential as a therapeutic approach in AF. Based on available data, current guidelines recommend alcohol abstinence or reduction to decrease AF symptoms, burden, and progression, and do not indicate the need for caffeine abstention to prevent AF episodes (unless it is a trigger for AF symptoms). Uncertainty persists regarding harms or benefits of other dietary factors including chocolate, fish, salt, polyunsaturated and monounsaturated fatty acids, vitamins, and micronutrients. This article provides a systematic review of the association between AF and both dietary patterns and components. Additionally, it discusses potentially related mechanisms and introduces different strategies to assess patients’ nutrition patterns, including mobile health solutions and diet indices. Finally, it highlights the gaps in knowledge requiring future investigation.
Untangling the colonization history of the Australo-Pacific reed warblers, one of the world’s great island radiations
Authors: Kearns Anna M , Campana Michael G , Slikas Beth , Berry Lainie , Saitoh Takema , Graves Gary R , Cibois Alice , Fleischer Robert C 
Published: September 2024

Abstract
Island radiations, such as those of the Australo-Pacific, offer unique insight into diversification, extinction, and early speciation processes. Yet, their speciation and colonization histories are often obscured by conflicting genomic signals from incomplete lineage sorting (ILS) or hybridization. Here, we integrated mitogenomes and genome-wide SNPs to unravel the evolutionary history of one of the world’s most geographically widespread island radiations. The Australo-Pacific reed warblers (Acrocephalus luscinius complex) are a speciose lineage including five species that have become extinct since the 19th century and ten additional species of conservation concern. The radiation spans over 10,000 km across Australo-Papua, Micronesia and Polynesia, including the Mariana, Hawaii and Pitcairn Island archipelagos. Earlier mtDNA studies suggested a stepping-stone colonization process, resulting in archipelago-level secondary sympatry of divergent mtDNA lineages in the Mariana Islands and Marquesas. These studies hypothesized that morphologically similar species on neighboring islands arose from ecological convergence. Using DNA from historical museum specimens and modern genetic samples, we show that ILS and/or gene flow have shaped the radiation of Australo-Pacific reed warblers rather than secondary sympatry. The nuclear genome reconstructs a simpler biogeographic history than mtDNA, showing close relationships between species in the Mariana Islands and Marquesas despite their paraphyletic mtDNA lineages. Gene flow likely involved early and late colonizing waves of the radiation before the loss of ancestral dispersive ability. Our results highlight how collection genomics can elucidate evolutionary history and inform conservation efforts for threatened species.
A haplotype-resolved, chromosome-scale genome for Malus domestica Borkh. ‘WA 38’
Authors: Zhang Huiting , Ko Itsuhiro , Eaker Abigail , Haney Sabrina , Khuu Ninh , Ryan Kara , Appleby Aaron B , Hoffmann Brendan , Landis Henry , Pierro Kenneth A , Willsea Noah , Hargarten Heidi , Yocca Alan E , Harkess Alex , Honaas Loren , Ficklin Stephen 
Published: September 2024

Abstract
Genome sequencing for agriculturally important Rosaceous crops has made rapid progress both in completeness and annotation quality. Whole genome sequence and annotation give breeders, researchers, and growers information about cultivar-specific traits such as fruit quality and disease resistance, and inform strategies to enhance postharvest storage. Here we present a haplotype-phased, chromosomal-level genome of Malus domestica, ‘WA 38’, a new apple cultivar released to market in 2017 as Cosmic Crisp®. Using both short and long-read sequencing data with a k-mer-based approach, chromosomes originating from each parent were assembled and segregated. This is the first pome fruit genome fully phased into parental haplotypes in which chromosomes from each parent are identified and separated into their unique, respective haplomes. The two haplome assemblies, ‘Honeycrisp’ originated HapA and ‘Enterprise’ originated HapB, are about 650 Megabases each, and both have a BUSCO score of 98.7% complete. A total of 53,028 and 54,235 genes were annotated from HapA and HapB, respectively. Additionally, we provide genome-scale comparisons to ‘Gala’, ‘Honeycrisp’, and other relevant cultivars highlighting major differences in genome structure and gene family circumscription. This assembly and annotation was done in collaboration with the American Campus Tree Genomes project that includes ‘WA 38’ (Washington State University), ‘d’Anjou’ pear (Auburn University), and many more. To ensure transparency, reproducibility, and applicability for any genome project, our genome assembly and annotation workflow is recorded in detail and shared under a public GitLab repository. All software is containerized, offering a simple implementation of the workflow.
The Raf/LIN-45 C-terminal distal tail segment negatively regulates signaling in Caenorhabditis elegans
Authors: Townley Robert A , Stacy Kennedy S , Cheraghi Fatemeh , de la Cova Claire C 
Published: September 2024

Abstract
Raf protein kinases act as Ras-GTP sensing components of the ERK signal transduction pathway in animal cells, influencing cell proliferation, differentiation, and survival. In humans, somatic and germline mutations in the genes BRAF and RAF1 are associated with malignancies and developmental disorders. Recent studies shed light on the structure of activated Raf, a heterotetramer consisting of Raf and 14-3-3 dimers, and raised the possibility that a Raf C-terminal distal tail segment (DTS) regulates activation. We investigated the role of the DTS using the Caenorhabditis elegans Raf ortholog lin-45. Truncations removing the DTS strongly enhanced lin-45(S312A), a weak gain-of-function allele equivalent to RAF1 mutations found in patients with Noonan Syndrome. We genetically defined three elements of the LIN-45 DTS, which we termed the active site binding sequence (ASBS), the KTP motif, and the aromatic cluster. In the context of lin-45(S312A), the mutation of each of these elements enhanced activity. We used AlphaFold to predict DTS protein interactions for LIN-45, fly Raf, and human BRAF within the activated heterotetramer complex. We propose the following distinct functions for the LIN-45 DTS elements: (1) the ASBS binds the kinase active site as an inhibitor; (2) phosphorylation of the KTP motif modulates the DTS–kinase domain interaction; and (3) the aromatic cluster anchors the DTS in an inhibitory conformation. Human RASopathy-associated variants in BRAF affect residues of the DTS, consistent with these predictions. This work establishes that the Raf/LIN-45 DTS negatively regulates signaling in C. elegans and provides a model for its function in other Raf proteins.
Seeking Dental Healthcare in the Context of COVID-19 Pandemic: A Study Examining the Health Belief Model
Authors: Goldstein Aviv , Matalon Shlomo , Fridenberg Na’ama , Slutzky Hagay 
Published: September 2024

Abstract

Background and Objectives
The main purpose of the study was to examine the factors influencing older adults’ seeking dental care, in the context of coronavirus disease 2019 (COVID-19) pandemic, based on the Health Belief Model (HBM).

Research Design and Methods
Phone interviews were conducted using a structured questionnaire, among 200 older adults aged 65 and above, who are members of the Israeli largest sick fund Clalit Health Services, that were sampled through a systematic random sample. The data were collected between January 2022 and March 2022 and during September 2022.

Results
Our findings indicate that since the outbreak of COVID-19 in Israel, 61.5% and 55% of the participants reported visiting a dentist and a dental hygienist, respectively, and about a fifth of the participants have foregone care at both. Seeking dental care was associated with an increase in perceived threat, benefits, willingness to seek care, and with a decrease in perceived barriers. The HBM was found to be a suitable framework for illuminating older adults’ dental behavior, which explains 43% of the variance.

Discussion and Implications
The results of the study provided first-hand findings regarding seeking dental care during the COVID-19 pandemic. These findings emphasize the importance of providing dental services with clear recommendations about dental care and appropriate protective equipment, even under conditions of health concern, to enhance oral health services utilization.
The financial burden of noncommunicable diseases from out-of-pocket expenditure in sub-Saharan Africa: a scoping review
Authors: Odunyemi Adelakun , Islam Md Tauhidul , Alam Khurshid 
Published: September 2024

Abstract
The growing financial burden of noncommunicable diseases (NCDs) in sub-Saharan Africa (SSA) hinders the attainment of the sustainable development goals. However, there has been no updated synthesis of evidence in this regard. Therefore, our study summarizes the current evidence in the literature and identifies the gaps. We systematically search relevant databases (PubMed, Scopus, ProQuest) between 2015 and 2023, focusing on empirical studies on NCDs and their financial burden indicators, namely, catastrophic health expenditure (CHE), impoverishment, coping strategies, crowding-out effects and unmet needs for financial reasons (UNFRs) in SSA. We examined the distribution of the indicators, their magnitudes, methodological approaches and the depth of analysis. The 71 included studies mostly came from single-country (n = 64), facility-based (n = 52) research in low-income (n = 22), lower-middle-income (n = 47) and upper-middle-income (n = 10) countries in SSA. Approximately 50% of the countries lacked studies (n = 25), with 46% coming from West Africa. Cancer, cardiovascular disease (CVD) and diabetes were the most commonly studied NCDs, with cancer and CVD causing the most financial burden. The review revealed methodological deficiencies related to lack of depth, equity analysis and robustness. CHE was high (up to 95.2%) in lower-middle-income countries but low in low-income and upper-middle-income countries. UNFR was almost 100% in both low-income and lower-middle-income countries. The use of extreme coping strategies was most common in low-income countries. There are no studies on crowding-out effect and pandemic-related UNFR. This study underscores the importance of expanded research that refines the methodological estimation of the financial burden of NCDs in SSA for equity implications and policy recommendations.