bluuebunny/crossref_metadata_2025_split huggingface dataset:
Where are the binaries in proto-planetary nebulae? Results of a long-term radial velocity study
Authors: Hrivnak Bruce J. , Van Winckel Hans , Van de Steene Griet , Bohlender David , Sperauskas Julius , Lu Wenxian 
Published: August 2017

AbstractWe present the results of a long-term search (25 yrs) for radial velocity variability in a sample of seven bright proto-planetary nebulae showing axial symmetry. They all vary in velocity due to periodic pulsations. However, only marginal evidence is found for multi-year variations that might be due to a binary companion.
Close binary central stars and the abundance discrepancy - new extreme objects
Authors: Wesson R. , Jones D. , García-Rojas J. , Corradi R. L. M. , Boffin H. M. J. 
Published: August 2017

AbstractRecent work (Corradi et al. 2015; Jones et al. 2016) has shown that the phenomenon of extreme abundance discrepancies, where recombination line abundances exceed collisionally excited line abundances by factors of 10 or more, seem to be strongly associated with planetary nebulae with close binary central stars. To further investigate, we have obtained spectra of a sample of nebulae with known close binary central stars, using FORS2 on the VLT, and we have discovered several new extreme abundance discrepancy objects. We did not find any non-extreme discrepancies, suggesting that a very high fraction of nebulae with close binary central stars also have an extreme abundance discrepancy.
Gaia and the Planetary Nebulae
Authors: Manteiga Minia , Dafonte Carlos , Álvarez Marco A. , Garabato Daniel , Ulla Ana , Jordi Carme 
Published: August 2017

AbstractAbout three years after Gaia was set into orbit, the first release of Gaia data, DR1, has been published by ESA and DPAC. Gaia’s first archive contains the results from the analysis of the initial 14 months of mission data. Outstandingly, it includes TGAS, Gaia-Tycho2 astrometric solution for about 2 million stars up to visible magnitude around 11.5.In addition to the five parameter astrometric solution for the sky (positions, parallaxes and proper motions), future Gaia data releases will provide the spectral energy distributions from 330-1050 nm, together with radial velocities, for sources brighter than visible magnitude 16. Within this context, the relevance of Gaia data for the study of PN is be briefly presented.
Post-common envelope PN, fundamental or irrelevant?
Authors: De Marco Orsola , Reichardt T. , Iaconi R. , Hillwig T. , Jacoby G. H. , Keller D. , Izzard R. G. , Nordhaus J. , Blackman E. G. 
Published: August 2017

AbstractOne in 5 PN are ejected from common envelope binary interactions butKeplerresults are already showing this proportion to be larger. Their properties, such as abundances can be starkly different from those of the general population, so they should be considered separately when using PN as chemical or population probes. Unfortunately post-common envelope PN cannot be discerned using only their morphologies, but this will change once we couple our new common envelope simulations with PN formation models.
Study of protoplanetary nebulae
Authors: Estrella D. , Hernández-Martínez L. , Velázquez P. F. , Esquivel A. , Raga C. A. 
Published: August 2017

AbstractWe have performed 3D hydrodynamic simulations of a symmetrical jet ejection following previous works (Raga et al. 2009, Riera et al. 2014, Velázquez et al. 2014). The jet is emitted from a binary system in elliptical orbit, and its direction changes describing a precession cone. We have considered that the jet has a time-dependence density ejection or a time-dependence velocity ejection, in order to propose an alternative model to explain the morphology of PPNe’s. Also in our description we have included the effect of the photoionization of the central source. From numerical results, synthetic Hα maps were obtained, and a proper motion study were carried out. We found that the photoionization has an important effect on the case with variation density resulting in a increse in the Hα emission.
Gaia: mapping the dynamics and morphologies of Galactic Planetary Nebulae: First results from Gaia Data Release 1
Authors: Walton Nicholas A. , Rejkuba Marina , Walsh Jeremy R. , Zijstra Albert A. 
Published: August 2017

AbstractThis paper comments on the use Gaia in studying the internal dynamics and morphologies of Planetary Nebulae (PN). It is noted that the second and subsequent releases of Gaia data, will have significant potential in unravelling PN morphologies.
Infrared studies of post-AGB stars and PNe
Authors: Suh Kyung-Won 
Published: August 2017

AbstractWe present infrared two color diagrams (2CDs) for a large sample of AGB stars, post-AGB stars, and planetary nebulae (PNe) to study their spectral evolution in infrared bands. We discuss possible evolutionary tracks from AGB stars to PNe on the 2CDs. We use catalogs from the available literature for the sample of AGB stars, post-AGB stars, and PNe in our Galaxy.
Challenges faced by current Galactic planetary nebula surveys
Authors: Frew David J. 
Published: August 2017

AbstractDetermining the demographics of the Galactic planetary nebula (PN) population is an important goal to further our understanding of this intriguing phase of stellar evolution. The Galactic population has more than doubled in number over the last 15 years, particularly from narrowband Hα surveys along the plane. In this review I will summarise these results, with emphasis on the time interval since the last IAU Symposium. These primarily optical surveys are not without their limitations and new surveys for PNe in the infrared similarly face a number of challenges. I will discuss the need for multi-wavelength approaches to discovery and analysis. The desire to have accurate volume-limited samples of Galactic PNe at our disposal is emphasised, which will be impacted with new data from the Gaia satellite mission. We need robust surveys of PNe and their central stars, especially volume-limited surveys, in order to clarify and quantify their evolutionary pathways.
Modeling time-series data from microbial communities
Authors: Ridenhour Benjamin J , Brooker Sarah L , Williams Janet E , Van Leuven James T , Miller Aaron W , Dearing M Denise , Remien Christopher H 
Published: August 2017

AbstractAs sequencing technologies have advanced, the amount of information regarding the composition of bacterial communities from various environments (for example, skin or soil) has grown exponentially. To date, most work has focused on cataloging taxa present in samples and determining whether the distribution of taxa shifts with exogenous covariates. However, important questions regarding how taxa interact with each other and their environment remain open thus preventing in-depth ecological understanding of microbiomes. Time-series data from 16S rDNA amplicon sequencing are becoming more common within microbial ecology, but methods to infer ecological interactions from these longitudinal data are limited. We address this gap by presenting a method of analysis using Poisson regression fit with an elastic-net penalty that (1) takes advantage of the fact that the data are time series; (2) constrains estimates to allow for the possibility of many more interactions than data; and (3) is scalable enough to handle data consisting of thousands of taxa. We test the method on gut microbiome data from white-throated woodrats (Neotoma albigula) that were fed varying amounts of the plant secondary compound oxalate over a period of 22 days to estimate interactions between OTUs and their environment.
Lithium enrichment in intracontinental rhyolite magmas leads to Li deposits in caldera basins
Authors: Benson Thomas R. , Coble Matthew A. , Rytuba James J. , Mahood Gail A. 
Published: August 2017

AbstractThe omnipresence of lithium-ion batteries in mobile electronics, and hybrid and electric vehicles necessitates discovery of new lithium resources to meet rising demand and to diversify the global lithium supply chain. Here we demonstrate that lake sediments preserved within intracontinental rhyolitic calderas formed on eruption and weathering of lithium-enriched magmas have the potential to host large lithium clay deposits. We compare lithium concentrations of magmas formed in a variety of tectonic settings using in situ trace-element measurements of quartz-hosted melt inclusions to demonstrate that moderate to extreme lithium enrichment occurs in magmas that incorporate felsic continental crust. Cenozoic calderas in western North America and in other intracontinental settings that generated such magmas are promising new targets for lithium exploration because lithium leached from the eruptive products by meteoric and hydrothermal fluids becomes concentrated in clays within caldera lake sediments to potentially economically extractable levels.
Adaptive and non-adaptive divergence in a common landscape
Authors: Raeymaekers Joost A. M. , Chaturvedi Anurag , Hablützel Pascal I. , Verdonck Io , Hellemans Bart , Maes Gregory E. , De Meester Luc , Volckaert Filip A. M. 
Published: August 2017

AbstractSpecies in a common landscape often face similar selective environments. The capacity of organisms to adapt to these environments may be largely species specific. Quantifying shared and unique adaptive responses across species within landscapes may thus improve our understanding of landscape-moderated biodiversity patterns. Here we test to what extent populations of two coexisting and phylogenetically related fishes—three-spined and nine-spined stickleback—differ in the strength and nature of neutral and adaptive divergence along a salinity gradient. Phenotypic differentiation, neutral genetic differentiation and genomic signatures of adaptation are stronger in the three-spined stickleback. Yet, both species show substantial phenotypic parallelism. In contrast, genomic signatures of adaptation involve different genomic regions, and are thus non-parallel. The relative contribution of spatial and environmental drivers of population divergence in each species reflects different strategies for persistence in the same landscape. These results provide insight in the mechanisms underlying variation in evolutionary versatility and ecological success among species within landscapes.
Micromotor-enabled active drug delivery for in vivo treatment of stomach infection
Authors: de Ávila Berta Esteban-Fernández , Angsantikul Pavimol , Li Jinxing , Angel Lopez-Ramirez Miguel , Ramírez-Herrera Doris E. , Thamphiwatana Soracha , Chen Chuanrui , Delezuk Jorge , Samakapiruk Richard , Ramez Valentin , Obonyo Marygorret , Zhang Liangfang , Wang Joseph 
Published: August 2017

AbstractAdvances in bioinspired design principles and nanomaterials have led to tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities in different environments. However, a significant gap remains in moving nano/micromotors from test tubes to living organisms for treating diseases with high efficacy. Here we present the first, to our knowledge, in vivo therapeutic micromotors application for active drug delivery to treat gastric bacterial infection in a mouse model using clarithromycin as a model antibiotic and Helicobacter pylori infection as a model disease. The propulsion of drug-loaded magnesium micromotors in gastric media enables effective antibiotic delivery, leading to significant bacteria burden reduction in the mouse stomach compared with passive drug carriers, with no apparent toxicity. Moreover, while the drug-loaded micromotors reach similar therapeutic efficacy as the positive control of free drug plus proton pump inhibitor, the micromotors can function without proton pump inhibitors because of their built-in proton depletion function associated with their locomotion.
Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations
Authors: Kim-Hellmuth Sarah , Bechheim Matthias , Pütz Benno , Mohammadi Pejman , Nédélec Yohann , Giangreco Nicholas , Becker Jessica , Kaiser Vera , Fricker Nadine , Beier Esther , Boor Peter , Castel Stephane E. , Nöthen Markus M. , Barreiro Luis B. , Pickrell Joseph K. , Müller-Myhsok Bertram , Lappalainen Tuuli , Schumacher Johannes , Hornung Veit 
Published: August 2017

AbstractThe immune system plays a major role in human health and disease, and understanding genetic causes of interindividual variability of immune responses is vital. Here, we isolate monocytes from 134 genotyped individuals, stimulate these cells with three defined microbe-associated molecular patterns (LPS, MDP, and 5′-ppp-dsRNA), and profile the transcriptomes at three time points. Mapping expression quantitative trait loci (eQTL), we identify 417 response eQTLs (reQTLs) with varying effects between conditions. We characterize the dynamics of genetic regulation on early and late immune response and observe an enrichment of reQTLs in distal cis-regulatory elements. In addition, reQTLs are enriched for recent positive selection with an evolutionary trend towards enhanced immune response. Finally, we uncover reQTL effects in multiple GWAS loci and show a stronger enrichment for response than constant eQTLs in GWAS signals of several autoimmune diseases. This demonstrates the importance of infectious stimuli in modifying genetic predisposition to disease.
Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors
Authors: Premarathne Susitha , Murtaza Mariyam , Matigian Nicholas , Jolly Lachlan A. , Wood Stephen A. 
Published: August 2017

AbstractDevelopment of neural progenitors depends upon the coordination of appropriate intrinsic responses to extrinsic signalling pathways. Here we show the deubiquitylating enzyme, Usp9x regulates components of both intrinsic and extrinsic fate determinants. Nestin-cre mediated ablation of Usp9x from embryonic neural progenitors in vivo resulted in a transient disruption of cell adhesion and apical-basal polarity and, an increased number and ectopic localisation of intermediate neural progenitors. In contrast to other adhesion and polarity proteins, levels of β-catenin protein, especially S33/S37/T41 phospho-β-catenin, were markedly increased in Usp9x−/Y
embryonic cortices. Loss of Usp9x altered composition of the β-catenin destruction complex possibly impeding degradation of S33/S37/T41 phospho-β-catenin. Pathway analysis of transcriptomic data identified Wnt signalling as significantly affected in Usp9x−/Y
embryonic brains. Depletion of Usp9x in cultured human neural progenitors resulted in Wnt-reporter activation. Usp9x also regulated components of the Notch signalling pathway. Usp9x co-localized and associated with both Itch and Numb in embryonic neocortices. Loss of Usp9x led to decreased Itch and Numb levels, and a concomitant increase in levels of the Notch intracellular domain as well as, increased expression of the Notch target gene Hes5. Therefore Usp9x modulates and potentially coordinates multiple fate determinants in neural progenitors.
GLP-1 Inhibits High-Glucose-Induced Oxidative Injury of Vascular Endothelial Cells
Authors: Li Quan , Lin Yajun , Wang Shu , Zhang Lina , Guo Lixin 
Published: August 2017

AbstractThe aim of this work was to evaluate the effects of glucagon-like peptide-1 (GLP-1) on high-glucose-induced oxidative stress and investigate the possible mechanisms underlying this process. We measured reactive oxygen species (ROS) production, cell apoptosis, the expression of NOX4 and its subunits, and p47phox translocation in human umbilical vein endothelial cells (HUVECs). An experimental type 2 diabetes model was induced using streptozotocin in male Sprague-Dawley rats. Fasting blood glucose (FBG), fasting insulin (FINS), total cholesterol (TC), triglycerides (TGs), and free fatty acid (FFA) were measured. Histomorphological analysis of the aorta was performed using hematoxylin-eosin staining. NOX4 and VCAM-1 expression in the aorta was measured. We found that high-glucose-induced ROS production and apoptosis were inhibited by GLP-1 treatment. High glucose caused upregulation of NOX4, p47phox, and Rac-1 and translocation of p47phox but had no effect on the cells pretreated with GLP-1. Furthermore, in the diabetic group, FBG, FINS, TG, TC, and FFA were increased, and NOX4 and VCAM-1 levels were also elevated. However, GLP-1 attenuated all these changes. GLP-1 ameliorated high-glucose-induced oxidative stress by inhibiting NOX4, p47phox, and Rac-1 expression and translocation of p47phox, suggesting its clinical usefulness in diabetic vascular complications.
Cardiorespiratory optimization during improvised singing and toning
Authors: Bernardi N. F. , Snow S. , Peretz I. , Orozco Perez H. D. , Sabet-Kassouf N. , Lehmann A. 
Published: August 2017

AbstractWe evaluated the effect of different forms of singing on cardiorespiratory physiology, and we aimed at disentangling the role of breathing from that of vocal production. Cardiorespiratory recordings were obtained from 20 healthy adults at rest and during: a) singing of familiar slow songs as in the standard form of Western culture; b) improvised vocalization of free vowel sounds, known as toning. To disentangle the role of breathing from that of vocal production, we compared the vocal conditions with matched breathing-only conditions. Toning significantly improved heart rate variability, ventilatory efficiency and slowed respiration to almost exactly six breaths per minute (p < 0.001), a pattern that is known to optimize cardiovascular function and that coincides with the period of endogenous circulatory rhythms. Singing songs also positively impacted cardiorespiratory function, although to a lesser extent. The breathing pattern imposed upon participants in the absence of vocal production was sufficient to generate the physiological benefits. The effects of toning are similar to what has been previously described as a result of engaging in formal breathing exercises. Toning and singing may offer an engaging and cost effective tool to trigger beneficial respiratory patterns and the related cardiovascular benefits.
Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression
Authors: Di Benedetto Anna , Ercolani Cristiana , Mottolese Marcella , Sperati Francesca , Pizzuti Laura , Vici Patrizia , Terrenato Irene , Shaaban Abeer M. , Humphries Matthew P. , Di Lauro Luigi , Barba Maddalena , Vitale Ilio , Ciliberto Gennaro , Speirs Valerie , De Maria Ruggero , Maugeri-Saccà Marcello 
Published: August 2017

AbstractThe ATR-Chk1 and ATM-Chk2 pathways are central in DNA damage repair (DDR) and their over-activation may confer aggressive molecular features, being an adaptive response to endogenous DNA damage and oncogene-induced replication stress. Herein we investigated the ATR-Chk1 and ATM-Chk2 signalings in male breast cancer (MBC). The expression of DDR kinases (pATR, pATM, pChk1, pChk2, and pWee1) and DNA damage markers (pRPA32 and γ-H2AX) was evaluated by immunohistochemistry in 289 MBC samples to assess their association. Survival analyses were carried out in 112 patients. Survival curves were estimated with the Kaplan-Meier method and compared by log-rank test. Cox proportional regression models were generated to identify variables impacting survival outcomes. The expression of pATR conferred poorer survival outcomes (log rank p = 0.013, p = 0.007 and p = 0.010 for overall, 15- and 10-year survival, respectively). Multivariate Cox models of 10-year survival and overall indicated that pATR expression, alone or combined with pChk2, was an independent predictor of adverse outcomes (10-year survival: pATR: HR 2.74, 95% CI: 1.23–6.10; pATR/pChk2: HR 2.92, 95% CI: 1.35–6.33; overall survival: pATR: HR 2.58, 95% CI: 1.20–5.53; pATR/pChk2: HR 2.89, 95% CI: 1.37–6.12). Overall, the ATR/ATM-initiated molecular cascade seems to be active in a fraction of MBC patients and may represent a negative prognostic factor.
Hypoxia-induced TET1 facilitates trophoblast cell migration and invasion through HIF1α signaling pathway
Authors: Zhu Jingping , Wang Kai , Li Ting , Chen Jiayu , Xie Dandan , Chang Xinwen , Yao Julei , Wu Jinting , Zhou Qian , Jia Yuanhui , Duan Tao 
Published: August 2017

AbstractLow oxygen is a typical extrinsic factor for the regulation of trophoblast biological function, including cell migration, invasion and proliferation. Ten-eleven translocation methylcytosine dioxygenase 1 (TET1), an enzyme converting 5-methylcytosine (5-mC) to 5-hydroxymethylcytosine (5-hmC), is transcriptionally activated by hypoxia in cancer cells. Therefore, we focus on the role of TET1 on trophoblast function in a physiologically hypoxic environment (3% oxygen), which is related to early placentation. Here, we found that TET1 was highly expressed in first trimester villi compared with normal term placentas. In vitro, both TET1 mRNA and protein expression levels in JEG3 cells were increased following exposure to 3% oxygen, and the migration and invasion capacities of JEG3 cells were up-regulated. Furthermore, TET1 knockdown decreased the migration, invasion and proliferation of JEG3 cells exposed to 3% oxygen, and the expression of HIF1α and its downstream target genes was also decreased, which was related to hyper-methylation of the HIF1α promoter. Finally, increased HIF1α protein expression reversed the inhibitory effect of TET1 knockdown on the migration and invasion of JEG3 cells exposed to 3% oxygen. These data show that hypoxia-induced TET1 expression facilitates trophoblast cell migration and invasion through the HIF1α signaling pathway, which plays an important role during placentation.
A synthetic analysis of greenhouse gas emissions from manure amended agricultural soils in China
Authors: Ren Fengling , Zhang Xubo , Liu Jian , Sun Nan , Wu Lianhai , Li Zhongfang , Xu Minggang 
Published: August 2017

AbstractApplication of manure has been recommended as an effective strategy to to mitigate climate change. However, the magnitude of greenhouse gases emission derived by application of manure to agricultural soils across environmental conditions still remains unclear. Here, we synthesized data from 379 observations in China and quantified the responses of soil nitrous oxide (N2O), carbon dioxide (CO2) and methane (CH4) emissions to manure (Org-M) in comparison to chemical fertilizers (Min-F) or non-fertilizers (Non-F). The results showed that N2O, CO2and CH4emissions were significantly affected by Org-M compared to Min-F (percentage change: −3, +15 and +60%,P < 0.05) and Non-F (percentage change: +289, +84 and +83%,P < 0.05), respectively. However, at the same amount of total N input, Org-M decreased soil N2O emission by 13% and CH4emission by 12%, and increased soil CO2emission by 26% relative to Min-F in upland soils. For paddy soils, N2O, CO2and CH4emissions differed by −3%, −36% and +84% between Org-M and Min-F (i.e., Org-M minus Min-F). Thus, practices such as application of manure instead of chemical fertilizer and decreasing nitrogen input rate need to be highly considered and optimized under different soils and climate conditions to mitigate GHGs emission in China.