bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term effect of intensive lifestyle intervention on cardiovascular risk factors in patients with diabetes in real-world clinical practice: a 5-year longitudinal study
Authors: Hamdy Osama , Mottalib Adham , Morsi Amr , El-Sayed Nuha , Goebel-Fabbri Ann , Arathuzik Gillian , Shahar Jacqueline , Kirpitch Amanda , Zrebiec John 
Published: January 2017

ObjectiveWe evaluated long-term impact of sustained weight loss versus weight regain on cardiovascular risk factors in real-world clinical practice.MethodsWe evaluated 129 obese patients with diabetes enrolled in Weight Achievement and Intensive Treatment (Why WAIT) program, a 12-week clinical model of intensive lifestyle intervention. After 1 year, we divided participants into group A, who maintained <7% weight loss (47.3%) and group B (52.7%), who maintained ≥7% weight loss. We continued to follow them for a total of 5 years.ResultsThe total cohort lost 23.8 lbs (−9.7%) at 12 weeks and maintained −16.2 lbs (−6.4%) at 5 years (p<0.001). Group A maintained −8.4 lbs (−3.5%) and group B maintained −23.1 lbs (−9.0%) at 5 years. In group A, A1C decreased from 7.5±1.3% to 6.7±0.9% at 12 weeks but increased to 7.7±1.4% at 1 year and 8.0±1.9% at 5 years. In group B, A1C decreased from 7.4±1.2% to 6.4±0.9% at 12 weeks and rose to 6.8±1.2% at 1 year and 7.3±1.5% at 5 years. Despite weight regain, group A maintained improvement in low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol with worsening of serum triglycerides and no change in blood pressure (BP). Group B maintained improvement in lipid profile for 5 years and had significantly lower BP for 18 months.ConclusionsWeight reduction in patients with diabetes can be maintained for 5 years and is predicted by patients’ ability to maintain ≥7% weight loss at 1 year. A1C and triglycerides deteriorate with weight regain, while other lipid improvements are maintained. Sustained weight loss is associated with significantly lower A1C for 5 years and lowers BP for 18 months.Trial registration numberNCT01937845.
Associations between altered movement patterns during single-leg squat and muscle activity at weight-transfer initiation in individuals with anterior cruciate ligament injury
Authors: Trulsson Anna , Miller Michael , Gummesson Christina , Garwicz Martin 
Published: January 2017

BackgroundLittle is known about factors contributing to the altered movement patterns observed in many individuals with anterior cruciate ligament (ACL) injury. We addressed whether altered muscular activity is such a factor.Methods16 participants with unilateral, non-reconstructed ACL rupture were scored for altered movement patterns according to Test for Substitution Patterns (TSP), which includes the single-leg squat (SLS). Surface electromyography (SEMG), was recorded in the lower extremities at initiation of weight-transfer from double-leg to single-leg stance (eyes closed), simulating the initiation of an SLS. Normalised SEMG amplitudes 200–300 ms after weight-transfer initiation were compared between injured and non-injured sides, and correlated to the TSP scores for the SLS. Peak absolute SEMG amplitudes during 5 TSP test movements were also compared between sides.ResultsAt weight-transfer initiation, muscle activity was lower in the tibialis anterior, gastrocnemius and peroneus longus muscles on the injured side. Low muscle activity correlated moderately to worse TSP scores for the SLS for the gluteus medius (rs=−0.56, p=0.03), and gastrocnemius muscles (rs=−0.56, p=0.02). Median peak absolute amplitude during TSP movements was lower in the quadriceps, gastrocnemius and peroneus longus muscles on the injured side.ConclusionsThe altered patterns of muscle activity at weight-transfer initiation, correlations between lower activity at movement initiation and altered movement patterns during SLS and the altered peak amplitudes during TSP movements together indicate alterations in sensorimotor control that may contribute to the observed altered movement patterns. Future studies will determine if exercises targeting muscle activity initiation should complement customary ACL injury rehabilitation.
Multireader assessment as an alternative to reference assessment to improve the detection of radiographic progression in a large longitudinal cohort of rheumatoid arthritis (ESPOIR)
Authors: Gandjbakhch Frederique , Granger Benjamin , Freund Romain , Foltz Violaine , Jousse-Joulin Sandrine , Devauchelle Valerie , Afshar Mona , Albert Jean David , Bailly Florian , Constant Elodie , Biale Lisa , Milin Morgane , Couderc Marion , Denarie Delphine , Fradin Anne , Martaille Virginie , Pierreisnard Audrey , Poursac Nicolas , Saraux Alain , Fautrel Bruno 
Published: January 2017

IntroductionStructural damage progression is a major outcome in rheumatoid arthritis (RA). Its evaluation and follow-up in trials should involve radiographic scoring by 1 or 2 readers (reference assessment), which is challenging in large longitudinal cohorts with multiple assessments.ObjectivesTo compare the reproducibility of multireader and reference assessment to improve the feasibility of detecting radiographic progression in a large cohort of patients with early arthritis (ESPOIR).MethodsWe used 3 sessions to train 12 rheumatologists in radiographic scoring by the van der Heijde-modified Sharp score (SHS). Multireader scoring was based on 10 trained-reader assessments, each reader scoring a random sample of 1/5 of all available radiographs (for double scoring for each X-ray set) for patients included in the ESPOIR cohort with complete radiographic data at M0 and M60. Reference scoring was performed by 2 experienced readers. Scoring was performed blindly to clinical data, with radiographs in chronological order. We compared multireader and reference assessments by intraclass correlation coefficients (ICCs) for SHS and significant radiographic progression (SRP).ResultsThe intrareader and inter-reader reproducibility for trained assessors increased during the training sessions (ICC 0.79 to 0.94 and 0.76 to 0.92), respectively. For the 524 patients included, agreement between multireader and reference assessment of SHS progression between M0 and M60 and SRP assessment were almost perfect, ICC (0.88 (95% CI 0.82 to 0.93)) and (0.99 (95% CI 0.99 to 0.99)), respectively.ConclusionsMultireader assessment of radiographic structural damage progression is comparable to reference assessment and could be used to improve the feasibility of radiographic scoring in large longitudinal cohort with numerous X-ray evaluations.
Chinese Atherosclerosis Risk Evaluation (CARE II) study: a novel cross-sectional, multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events—design and rationale
Authors: Zhao Xihai , Li Rui , Hippe Daniel S , Hatsukami Thomas S , Yuan Chun ,   CARE-II Investigators
Published: January 2017

BackgroundCarotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke. However, the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a large population.ObjectivesThe primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack (TIA). The relationship between carotid plaque features and cerebral infarcts, the differences of carotid plaque patterns among different regions of China and the gender specific characteristics of carotid plaque will be also determined.Study designThe CARE II study will enrol 1000 patients with recent ischaemic stroke or TIA and carotid plaque from 13 hospitals and medical centres across China. In this cross-sectional, non-randomised, observational, multicentre study, all patients will undergo carotid artery MRI of bilateral carotid arteries and routine brain MRI with standardised protocols. The MRI will be interpreted at core reading centres to evaluate the characteristics of morphology and compositions of carotid plaque.ConclusionsThis is a cross-sectional, multicentre study to investigate the prevalence and characteristics of high-risk atherosclerotic carotid plaque in Chinese patients with stroke and TIA by using high-resolution MRI of vessel wall. This trial is sufficiently powered to demonstrate the prevalence of carotid high-risk plaque and to explore regional differences in Chinese patients who suffered stroke.Trial registration numberNCT02017756.
DNA methylation assessment from human slow- and fast-twitch skeletal muscle fibers
Authors: Begue Gwénaëlle , Raue Ulrika , Jemiolo Bozena , Trappe Scott 
Published: January 2017

A new application of the reduced representation bisulfite sequencing method was developed using low-DNA input to investigate the epigenetic profile of human slow- and fast-twitch skeletal muscle fibers. Successful library construction was completed with as little as 15 ng of DNA, and high-quality sequencing data were obtained with 32 ng of DNA. Analysis identified 143,160 differentially methylated CpG sites across 14,046 genes. In both fiber types, selected genes predominantly expressed in slow or fast fibers were hypomethylated, which was supported by the RNA-sequencing analysis. These are the first fiber type-specific methylation data from human skeletal muscle and provide a unique platform for future research. NEW & NOTEWORTHY This study validates a low-DNA input reduced representation bisulfite sequencing method for human muscle biopsy samples to investigate the methylation patterns at a fiber type-specific level. These are the first fiber type-specific methylation data reported from human skeletal muscle and thus provide initial insight into basal state differences in myosin heavy chain I and IIa muscle fibers among young, healthy men.
Blood flow regulation and oxygen uptake during high-intensity forearm exercise
Authors: Nyberg S. K. , Berg O. K. , Helgerud J. , Wang E. 
Published: January 2017

The vascular strain is very high during heavy handgrip exercise, but the intensity and kinetics to reach peak blood flow, and peak oxygen uptake, are uncertain. We included 9 young (25 ± 2 yr) healthy males to evaluate blood flow and oxygen uptake responses during continuous dynamic handgrip exercise with increasing intensity. Blood flow was measured using Doppler-ultrasound, and venous blood was drawn from a deep forearm vein to determine arteriovenous oxygen difference (a-vO2diff) during 6-min bouts of 60, 80, and 100% of maximal work rate (WRmax), respectively. Blood flow and oxygen uptake increased ( P < 0.05) from 60%WRmax [557 ± 177(SD) ml/min; 56.0 ± 21.6 ml/min] to 80%WRmax (679 ± 190 ml/min; 70.6 ± 24.8 ml/min), but no change was seen from 80%WRmax to 100%WRmax. Blood velocity (49.5 ± 11.5 to 58.1 ± 11.6 cm/s) and brachial diameter (0.49 ± 0.05 to 0.50 ± 0.06 cm) showed concomitant increases ( P < 0.05) with blood flow from 60% to 80%WRmax, whereas no differences were observed in a-vO2diff. Shear rate also increased ( P < 0.05) from 60% (822 ± 196 s−1) to 80% (951 ± 234 s−1) of WRmax. The mean response time (MRT) was slower ( P < 0.05) for blood flow (60%WRmax 50 ± 22 s; 80%WRmax 51 ± 20 s; 100%WRmax 51 ± 23 s) than a-vO2diff (60%WRmax 29 ± 9 s; 80%WRmax 29 ± 5 s; 100%WRmax 20 ± 5 s), but not different from oxygen uptake (60%WRmax 44 ± 25 s; 80%WRmax 43 ± 14 s; 100%WRmax 41 ± 32 s). No differences were observed in MRT for blood flow or oxygen uptake with increased exercise intensity. In conclusion, when approaching maximal intensity, oxygen uptake appeared to reach a critical level at ~80% of WRmax and be regulated by blood flow. This implies that high, but not maximal, exercise intensity may be an optimal stimulus for shear stress-induced small muscle mass training adaptations. NEW & NOTEWORTHY This study evaluated blood flow regulation and oxygen uptake during small muscle mass forearm exercise with high to maximal intensity. Despite utilizing only a fraction of cardiac output, blood flow reached a plateau at 80% of maximal work rate and regulated peak oxygen uptake. Furthermore, the results revealed that muscle contractions dictated bulk oxygen delivery and yielded three times higher peak blood flow in the relaxation phase compared with mean values.
Orientation selectivity in the visual cortex of the nine-banded armadillo
Authors: Scholl Benjamin , Rylee Johnathan , Luci Jeffrey J. , Priebe Nicholas J. , Padberg Jeffrey 
Published: January 2017

Orientation selectivity in primary visual cortex (V1) has been proposed to reflect a canonical computation performed by the neocortical circuitry. Although orientation selectivity has been reported in all mammals examined to date, the degree of selectivity and the functional organization of selectivity vary across mammalian clades. The differences in degree of orientation selectivity are large, from reports in marsupials that only a small subset of neurons are selective to studies in carnivores, in which it is rare to find a neuron lacking selectivity. Furthermore, the functional organization in cortex varies in that the primate and carnivore V1 is characterized by an organization in which nearby neurons share orientation preference while other mammals such as rodents and lagomorphs either lack or have only extremely weak clustering. To gain insight into the evolutionary emergence of orientation selectivity, we examined the nine-banded armadillo, a species within the early placental clade Xenarthra. Here we use a combination of neuroimaging, histological, and electrophysiological methods to identify the retinofugal pathways, locate V1, and for the first time examine the functional properties of V1 neurons in the armadillo ( Dasypus novemcinctus) V1. Individual neurons were strongly sensitive to the orientation and often the direction of drifting gratings. We uncovered a wide range of orientation preferences but found a bias for horizontal gratings. The presence of strong orientation selectivity in armadillos suggests that the circuitry responsible for this computation is common to all placental mammals.NEW & NOTEWORTHY The current study shows that armadillo primary visual cortex (V1) neurons share the signature properties of V1 neurons of primates, carnivorans, and rodents. Furthermore, these neurons exhibit a degree of selectivity for stimulus orientation and motion direction similar to that found in primate V1. Our findings in armadillo visual cortex suggest that the functional properties of V1 neurons emerged early in the mammalian lineage, near the time of the divergence of marsupials.
Phase I Study of ONT-380, a HER2 Inhibitor, in Patients with HER2+-Advanced Solid Tumors, with an Expansion Cohort in HER2+ Metastatic Breast Cancer (MBC)
Authors: Moulder Stacy L. , Borges Virginia F. , Baetz Tara , Mcspadden Tessa , Fernetich Gina , Murthy Rashmi K. , Chavira Renae , Guthrie Kari , Barrett Emma , Chia Stephen K. 
Published: January 2017

Abstract
Purpose: ONT-380 (ARRY-380) is a potent and selective oral HER2 inhibitor. This Phase I study determined the MTD, pharmacokinetics (PK) and antitumor activity of ONT-380 in HER2-positive advanced solid tumors, with an expansion cohort of patients with HER2+ MBC.
Experimental Design: ONT-380 was administered twice daily (BID) in continuous 28-day cycles. After a modified 3+3 dose-escalation design determined the MTD, the expansion cohort was enrolled. PK properties of ONT-380 and a metabolite were determined. Response was evaluated by Response Evaluation Criteria in Solid Tumors (RECIST).
Results: Fifty patients received ONT-380 (escalation = 33; expansion = 17); 43 patients had HER2+ MBC. Median prior anticancer regimens = 5. Dose-limiting toxicities of increased transaminases occurred at 800 mg BID, thus 600 mg BID was the MTD. Common AEs were usually Grade 1/2 in severity and included nausea (56%), diarrhea (52%), fatigue (50%), vomiting (40%) constipation, pain in extremity and cough (20% each). 5 patients (19%) treated at MTD had grade 3 AEs (increased transaminases, rash, night sweats, anemia, and hypokalemia). The half-life of ONT-380 was 5.38 hours and increases in exposure were approximately dose proportional. In evaluable HER2+ MBC (n = 22) treated at doses ≥ MTD, the response rate was 14% [all partial response (PR)] and the clinical benefit rate (PR + stable disease ≥ 24 weeks) was 27%.
Conclusions: ONT-380 had a lower incidence and severity of diarrhea and rash than that typically associated with current dual HER2/EGFR inhibitors and showed notable antitumor activity in heavily pretreated HER2+ MBC patients, supporting its continued development. Clin Cancer Res; 23(14); 3529–36. ©2017 AACR.
Lugar de hija, lugar de madre. Autoficción y legados familiares en la narrativa de hijos de desaparecidos en Argentina
Authors: Peller Mariela 
Published: January 2017

En este artículo examino una serie de producciones de hijas de desaparecidos en Argentina. Los relatos ¿Quién te creés que sos? de Ángela Urondo Raboy (2012) y Aparecida de Marta Dillon (2015), y la instalación audiovisual Operación fracaso y el sonido recobrado de Albertina Carri (2015). Propongo que la experiencia de ser hija de desaparecidos y, luego, madre de nietos de desaparecidos, encuentra en la autoficción una forma de poder ser narrada y elaborada para sí y para otros. A partir de la experiencia de la propia maternidad, estas hijas despliegan un trabajo de narración y transmisión hacia las futuras generaciones, que supone una apertura hacia el futuro y una identificación con la propia madre. Ambas figuras de la madre, la madre-muerta y la hija-madre, se conforman como el motor de las obras. Escribir para saber, escribir como parte de un trabajo de duelo y también para transmitir y legar relatos a las futuras generaciones.
Geração 2,5: a shoá de Amir
Authors: Rozenchan Nancy 
Published: January 2017

O trauma da Shoá é sabidamente um dos componentes mais complexos da identidade israelense contemporânea. Ainda que tenham se passado décadas desde os trágicos eventos que afetaram criticamente o povo judeu, Israel, que absorveu a maioria dos sobreviventes da catástrofe, continua a tentar assimilar, geração após geração, as dores, perdas e tentativas de compreensão dos eventos da II Guerra relacionados à parte de sua população. À literatura hebraica cabe um papel primordial na exposição das diversas questões aí abrangidas, assim como de atualização dos sentimentos e forma de expressão que continuam a se alterar nos anos que se seguiram. Partindo dos primeiros registros literários relacionados à Shoá, o presente texto fixa-se, por fim, em um dos romances mais destacados dos últimos tempos, Shoá shelanu [Nossa Shoá], de Amir Gutfreund, Tel Aviv, Ed. Zamora-Beitan, 2000, que explora a temática pela visão da geração de descendentes de sobreviventes.
Imitação de Retóricas Latinas na Concepção de Gêneros e Estilos da Musica Poetica
Authors: Lucas Monica 
Published: January 2017

A vinculação entre a música e as artes do trivium remonta a uma tradição antiga. Contudo, foi na pena de escritores luteranos do início do século XVII que a música e a palavra se aproximaram de maneira sistemática, de modo que a primeira passou a ser entendida como arte persuasiva, sujeita a regras gramáticais e retóricas. A transferência destes preceitos verbais para a composição musical se deu de maneira cada vez mais intensa a partir do século XVI, perdurando até o fim do séc. XVIII. Essas transposições formaram a base da teoria de composição musical conhecida no mundo luterano como musica poetica. Neste artigo, concentrar-nos-emos na teoria retórica dos gêneros e estilos musicais, como compreendida em preceptivas seiscentistas e setecentistas. Mostraremos como a musica poetica foi se aproximando dos ideais retóricos humanistas e como esta aproximação colaborou para consolidar a ideia de música como linguagem, no final do séc. XVIII.
Fabritio Caroso’s Balletti: “The dancer’s own language?”
Authors: Collins Mary 
Published: January 2017

In the 16th Century, ladies and gentlemen of noble birth were taught from an early age the art of dancing, necessary to survive in the hierarchical world of the court. A Neo-Platonic perspective on dancing was at the core of Renaissance thinking (Humanism) and persisted throughout the 17th Century. In dance circles the principles of harmony and order in the cosmos, harking back to the classical world of Plato and Quintilian, were already well established in Italy by the end of the 15th Century. The balli were structures consisting of many different rhythmic sections throughout which a playful narrative of love, courtship and drama unfolded. By the second half of the 16th Century, two notable dancing masters, Fabritio Caroso and Cesare Negri, were beginning to record their teaching and advice in manuals, which serve as the first known comprehensive and detailed treatises on court dance. By the late 16th Century, the balletto still involved the theatricality of narrative and contrasting or varying emotions. It was still a performance or game for the spectators as well as for the dancers themselves, despite being performed in a social context. In this article, we take a closer look at two balli presented by Caroso: Ardente Sole and Laura Soave, showing that their structure was inspired by rhetorical principles.
Estaria Morto José Maurício?
Authors: Seincman Eduardo 
Published: January 2017

Após tantos anos, a despeito dos apelos de Mário de Andrade e de tantos outros, José Maurício continua a ser um "ilustre desconhecido". Ensaios biográficos proliferam, mas nós não sabemos quase nada a respeito de suas composições: não as conhecemos, não as contextualizamos, elas não atuam no presente de modo que possamos não apenas fruí-las, mas também re-significar nosso passado. Alguns mais afoitos arriscam-se, apressadamente, na empreitada de desvalorizar a qualidade das obras de José Maurício, comparando-o a Haydn e Mozart e mostrando a sua "insuficiência teórica" e a sua inferioridade técnica. A ótica puramente evolucionista e historicista anacroniza a obra de arte, principalmente quando ela está associada a uma "ideologia de submissão" que vê o artista da colônia como alguém que tenta, a qualquer custo, imitar a linguagem européia ocidental sem alcançar, no entanto, um padrão mínimo de qualidade e interesse, a não ser aquele puramente factual e datado. A audição da obra de José Maurício Nunes Garcia nos revela a presença não apenas de um "artesão", mas de um verdadeiro "inventor": por sob o texto propriamente dito, em que se mostra a sua grande habilidade técnica, navega uma estratégia composicional que o iguala a qualquer compositor, de qualquer época, digno deste nome. É necessário, portanto, reatualizar a obra de José Maurício, incorporando-o às nossas experiências musicais: estudos musicológicos e históricos associados a um trabalho permanente de edição, execução e interpretação, calcados em elementos de análise estética e composicional.
Análise de Transformações Temáticas no Op. 11 nº 1, de Arnold Schoenberg
Authors: Lima Paulo Costa 
Published: January 2017

Longe de ser uma área específica e relativamente isolada, a análise de relações motívicas e temáticas infiltra-se em vários contextos distintos, que incluem a análise tradicional, schenkeriana, análise de conjuntos, análise semiótica e, evidentemente, o núcleo especificamente voltado para este conceito. Após alguns comentários sobre este núcleo, passaremos a observar a op. 11 n° 1 sob este ponto de vista.
...La Bella e Agile sua Voce
Authors: Cagnin Antonio Luis 
Published: January 2017

O artigo resgata a figura de Raquel de Almeida. Ainda que não tenhamos quase nada sobre sua vida para lhe traçar o perfil e contar dos seus sucessos, e, sobretudo, responder à instigante pergunta sobre as recônditas razões que a tiraram do auge de sua glória para viver numa aldeia quase inacessível, encarapitada no planalto paulista, podemos afirmar que Raquel de Almeida foi a primeira cantora lírica de São Paulo.