bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Systematic Review of Mechanisms of Change in Body-Oriented Yoga in Major Depressive Disorders
Authors: Meister Klara , Juckel Georg 
Published: June 2017

Abstract
Introduction Despite empirical evidence for the efficacy of body-oriented yoga as add-on treatment for major depressive disorder (MDD), the specific mechanisms by which yoga leads to therapeutic changes remain unclear. By means of a systematic review, we evaluate how the field is progressing in its empirical investigation of mechanisms of change in yoga for MDD.
Methods To identify relevant studies, a systematic search was conducted.
Results The search produced 441 articles, of which 5 were included, that empirically examined 2 psychological mechanisms (mindfulness, rumination) and 3 biological mechanisms (vagal control, heart rate variability [HRV], brain-derived neurotrophic factor [BDNF], cortisol). 2 studies found that decreased rumination and 1 study that increased mindfulness was associated with the effect of yoga on treatment outcome. In addition, preliminary studies suggest that alterations in cortisol, BDNF, and HRV may play a role in how yoga exerts its clinical effect.
Discussion The results suggest that body-oriented yoga could work through some of the theoretically predicted mechanisms. However, there is a need for more rigorous designs that can assess greater levels of causal specificity.
Was there ever a “Female Gothic”?
Authors: Ledoux Ellen 
Published: June 2017

AbstractThis article examines the reception history of women-authored Gothic texts from the late eighteenth and early nineteenth century, arguing that the generic descriptor “Female Gothic” more accurately reflects the ideological goals of second-wave feminist literary criticism than the narratives of early women Gothic writers. While several critics have attempted to destabilize the term Female Gothic, its usage persists as a short-hand form to describe narratives in which distressed female heroines are imprisoned in the domestic sphere and threatened with extortion, rape and forced marriage. This essay asks why criticism clings to an understanding of this genre as one depicting female victimization despite overwhelming textual evidence that represents a much more complicated picture of women’s use and engagement with the Gothic mode. It is argued that the answer to this question rests in looking at how Gothic women’s writing was received in the early nineteenth century and how that reception history shaped the discursive strategies of second-wave feminist literary critics.
Longitudinal Form and the Human Conceptus
Authors: Fernandes Ashley K. 
Published: June 2017

Human rights are not a privilege conferred by the government They are every human being's entitlement by virtue of his humanity. The right to life does not depend, and must not be declared to be contingent, on the pleasure of anyone else, not even a parent or sovereign … I have no new teaching for America. I seek only to recall you to faithfulness to what you once taught the world Your nation was founded on the proposition — very old as a moral precept, but startling and innovative as political insight — that human life is a gift of immeasurable worth, and that it deserves, always and everywhere, to be treated with the utmost dignity and respect — Mother Theresa of Calcutta (1994) 1
Long-term Radiological and Clinical Outcomes After Using Bone Marrow Mesenchymal Stem Cells Concentrate Obtained With Selective Retention Cell Technology in Posterolateral Spinal Fusion
Authors: Yousef Mohamed Abdelhamid Ali , La Maida Giovanni Andrea , Misaggi Bernardo 
Published: June 2017

Study Design.
Retrospective study.

Objective.
The aim of this study was to evaluate the long-term clinical and radiological outcomes of the use of bone marrow mesenchymal stem cell concentrate obtained with selective cell retention technology using Cellect with a particular collagen scaffold, Healos for posterolateral spinal fusion.

Summary of Background Data.
With the increasing rate of spinal fusion, the problem of pseudarthrosis, which contributes to recurrent pain with patient disability, is considered to be the most common cause of revision lumbar spine surgery. Intensive research is being carried out to develop an alternative source of bone grafting and improve the spinal fusion rate.

Methods.
A retrospective review of hospital records was performed. Identified patients were contacted to have a clinical and radiological evaluation follow-up. Clinical outcome was evaluated using visual analog scales for the back pain (VAS), Oswestry Disability Index (ODI) scores, and quality of life (EQ-5D) questionnaire. Radiological outcome was evaluated by performing dynamic flexion/extension lateral views and calculation of segmental Cobb angle. Any implant-associated complication was reported. Computed tomography (CT) scans were also performed.

Results.
Twenty-one patients were included and all patients achieved successful fusion. The mean difference of the segmental Cobb angle was 0.48° (range 0.3°–0.7°). Computed tomography scans showed solid bilateral fusion with bridging bone (Grade I) in all patients, but solid unilateral fusion with bridging bone (Grade II) was detected for one patient at one level. Patients started to resume working activities within a mean period of 3.5 months. The VAS score for the residual back pain was 4.1 ± 2.1, whereas the ODI was 10.5 ± 5.6 points, and the mean disability index was 21.1%.

Conclusion.
The use of bone marrow mesenchymal stem cell concentrate obtained with selective cell retention technology could be considered as an effective means for augmenting spinal fusion.

Level of Evidence: 3
Research Use of Nurses Working in the Critical Care Units: Barriers and Facilitators
Authors: Hweidi Issa M. , Tawalbeh Loai Issa , Al-hassan Musa A. , Alayadeh Razan M. , Al-Smadi Ahmed Mohammad 
Published: June 2017

Background:
There is a distinct gap between theory and practice with respect to research use in clinical practice, particularly in critical care units, that could be related to the presence of a number of barriers that hinder the use of research findings.

Aims:
The aims of the study were to identify barriers and facilitators to research use as perceived by Jordanian nurses in critical care units and to examine the predictors of research use among those nurses.

Methods:
The study used a cross-sectional, correlational design. The self-administered “Barriers Scale” was introduced to 200 registered critical care nurses, using the drop-and-collect technique, between October and November 2015.

Results:
The results revealed that “nurse does not have time to read research at work” was the top ranked barrier that hinders research use (mean [SD], 3.45 [0.79]). The first 7 ranked barriers were related to the organizational subscale. Managerial support was the top perceived facilitator for research use. Only “attending special training courses in nursing research” was the significant predictor of research use and explained 59.1% of the variance in research use, t(190) = −3.93, P = .003. The most identified barriers toward research use revealed by the qualitative data include dominant routine nursing tasks, existence of gap between theory and practice, shortage of nursing staff, and public negative image about nursing profession. Participants suggested the importance of increasing organizational support and creating an organizational research culture to further promote research use in clinical nursing practice.

Conclusions:
Research use has not been widely implemented yet in Jordan because of various barriers. The organization-related barriers were the most influential. Factors hindering research use are multidimensional, and optimizing them should be a shared responsibility of nurse managers, researchers, clinicians, and academicians. Further initiatives are required to raise awareness of the importance of using evidence-based practice.
Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation
Authors: Grenald Shaness A. , Doyle Timothy M. , Zhang Hong , Slosky Lauren M. , Chen Zhoumou , Largent-Milnes Tally M. , Spiegel Sarah , Vanderah Todd W. , Salvemini Daniela 
Published: June 2017

Abstract
Metastatic bone pain is the single most common form of cancer pain and persists as a result of peripheral and central inflammatory, as well as neuropathic mechanisms. Here, we provide the first characterization of sphingolipid metabolism alterations in the spinal cord occurring during cancer-induced bone pain (CIBP). Following femoral arthrotomy and syngenic tumor implantation in mice, ceramides decreased with corresponding increases in sphingosine and the bioactive sphingolipid metabolite, sphingosine 1-phosphate (S1P). Intriguingly, de novo sphingolipid biosynthesis was increased as shown by the elevations of dihydro-ceramides and dihydro-S1P. We next identified the S1P receptor subtype 1 (S1PR1) as a novel target for therapeutic intervention. Intrathecal or systemic administration of the competitive and functional S1PR1 antagonists, TASP0277308 and FTY720/Fingolimod, respectively, attenuated cancer-induced spontaneous flinching and guarding. Inhibiting CIBP by systemic delivery of FTY720 did not result in antinociceptive tolerance over 7 days. FTY720 administration enhanced IL-10 in the lumbar ipsilateral spinal cord of CIBP animals and intrathecal injection of an IL-10 neutralizing antibody mitigated the ability of systemic FTY720 to reverse CIBP. FTY720 treatment was not associated with alterations in bone metabolism in vivo. Studies here identify a novel mechanism to inhibit bone cancer pain by blocking the actions of the bioactive metabolites S1P and dihydro-S1P in lumbar spinal cord induced by bone cancer and support potential fast-track clinical application of the FDA-approved drug, FTY720, as a therapeutic avenue for CIBP.
Post‐transplant Recurrent Bile Salt Export Pump Disease
Authors: Patel Kalyani R. , Harpavat Sanjiv , Finegold Milton , Eldin Karen , Hicks John , Firan Mihail , Keitel Verena , Kubitz Ralf , Wu Hao 
Published: June 2017

ABSTRACTRecurrent bile salt export pump (rBSEP) disease has been reported in progressive familial intrahepatic cholestasis type 2 (PFIC2) patients following liver transplantation (LT) and is often refractory to standard anti‐cellular rejection immunosuppressants. The mechanism of rBSEP disease is proposed to be a form of type II hypersensitivity reaction with de novo anti‐BSEP antibodies blocking the function of allograft BSEP. Utilization of C4d has not been evaluated in rBSEP. We describe a girl with 3 episodes of rBSEP with severe pruritus at 8.9, 10.3, and 11.0 years post‐LT, respectively. Patient's serum reacted with normal liver canaliculi by indirect immunofluorescence (IF), whereas patient's liver showed canalicular immunoglobulin G deposition. The histologic features of all 3 liver biopsies recapitulate PFIC2 with cholestatic giant cell hepatitis. Canalicular BSEP expression was not detected in areas of feathery degeneration by immunohistochemistry, but was retained in morphologically normal liver. By direct IF, C4d showed diffuse sinusoidal staining in the third biopsy. Patient responded well to rituximab with or without intravenous immunoglobulin with subsiding symptoms and normalization of serum bile acid levels. In conclusion, rBSEP disease should be considered in the differential diagnosis when evaluating for rejection in a PFIC2 patient post‐LT presenting with pruritus. A portion of liver core may be snap frozen in OCT medium for possible direct IF for C4d, that can serve as a surrogate marker for complement activation and antibody‐mediated graft dysfunction.
Intravenous Smart Pump Drug Library Compliance: A Descriptive Study of 44 Hospitals
Authors: Giuliano Karen K. , Su Wan-Ting , Degnan Daniel D. , Fitzgerald Kristy , Zink Richard J. , DeLaurentis Poching 
Published: June 2017

Background
Although intravenous (IV) smart pumps with built-in dose-error reduction systems (DERS) can reduce IV medication administration error, most serious adverse events still occur during IV medication administration. Sources of error include overriding DERS and manually bypassing drug libraries and the DERS.

Methods
Our purpose was to use the Regenstrief National Center for Medical Device Informatics data set to better understand IV smart pump drug library and DERS compliance. Our sample consisted of 12 months of data from 7 hospital systems, 44 individual hospitals, and descriptive data from the American Hospital Directory (AHD) for 2015. The aims of the study were (1) to determine whether there are differences in IV smart pump drug library compliance between hospital systems and (2) to provide a broad descriptive overview of relevant trends related to IV smart pump compliance.

Results
For aim 1, we found 3 significant relationships among the 7 hospital systems: systems 3 (P < 0.001), 6 (P = 0.003), and 7 (P = 0.002) had significantly higher IV smart compliance as compared with system 4. For aim 2, the number of drug library profiles was positively correlated (P = 0.029) with IV smart pump compliance and the IV smart pump type used was significantly correlated (P = 0.013) with IV smart pump compliance.

Conclusions
Our findings support that there are differences in IV smart pump compliance both within and between hospital systems and that IV smart pump type and the number of drug library profiles may be influencing factors. Further research is required to more accurately identify the impact of these factors in this very important area of patient safety.
Factors Associated With Global Variability in Electroconvulsive Therapy Utilization
Authors: Rakita Uros , Bingham Kathleen , Fung Kenneth , Giacobbe Peter 
Published: June 2017

Objectives
The aims of this study were to investigate the social and economic factors that contribute to global variability in electroconvulsive therapy (ECT) utilization and to contrast these to the factors associated with antidepressant medication rates.

Methods
Rates of ECT and antidepressant utilization across nations and data on health, social, and economic indices were obtained from multiple international organizations including the World Health Organization and the Organization for Economic Co-operation and Development, as well as from the published literature. To assess whether relationships exist between selected indices and each of the outcome measures, a correlational analysis was conducted using Pearson correlation coefficients. Those that were significant at a level of P < 0.05 in the correlation analysis were selected for entry into the multivariate analyses. Selected predictor variables were entered into a stepwise multiple regression models for ECT and antidepressant utilization rates separately.

Results
A stepwise multiple regression analysis indicated that government expenditure on mental health was the only significant contributor to the model, explaining 34.2% of global variation in ECT use worldwide. Human Development Index was the only variable found to be significantly correlated with global antidepressant utilization, accounting for 71% of the variation in global antidepressant utilization.

Conclusions
These findings suggest that across the globe ECT but not antidepressant medication utilization is associated with the degree to which a nation financially invests in mental health care for its citizens.
BioSharing: Harnessing Metadata Standards for the Data Commons
Authors: Sansone Susanna-Assunta , Gonzalez-Beltran Alejandra , Rocca-Serra Philippe , McQuilton Peter , Izzo Massimiliano , Lister Allyson , Thurston Milo 
Published: June 2017

ABSTRACTThe use of community-driven metadata standards, such as minimal information guidelines, terminologies, formats/models, is essential to ensure that data and other digital research outputs are Findable, Accessible, Interoperable, and Reusable, according to the FAIR principles. As with other types of digital assets, metadata standards also need be FAIR. Their discoverability and accessibility is ensured by BioSharing, the most comprehensive resource of metadata standards, interlinked to data repositories and policies, available in the life, environmental and biomedical sciences. With its growing content, endorsements, and collaborative network, BioSharing is part of a larger ecosystem of interoperable resources. Here we describe some of the activities under the USA National Institutes of Health (NIH)’s Big Data to Knowledge (BD2K) Initiative, illustrating how we track the evolution and use of metadata standards and work to connect them to indexes and annotation tools.
Foresight is required to enforce sustainability under time-delayed biodiversity loss
Authors: Lafuite A.-S. , de Mazancourt C. , Loreau M. 
Published: June 2017

AbstractNatural habitat loss and fragmentation generate a time-delayed loss of species and associated ecosystem services. Since social-ecological systems (SESs) depend on a range of ecosystem services, lagged ecological dynamics may affect their long-term sustainability. Here, we investigate the role of consumption changes in sustainability enforcement, under a time-delayed ecological feedback on agricultural production. We use a stylized model that couples the dynamics of biodiversity, technology, human demography and compliance to a social norm prescribing sustainable consumption. Compliance to the sustainable norm reduces both the consumption footprint and the vulnerability of SESs to transient overshoot-and-collapse population crises. We show that the timing and interaction between social, demographic and ecological feedbacks govern the transient and long-term dynamics of the system. A sufficient level of social pressure (e.g. disapproval) applied on the unsustainable consumers leads to the stable coexistence of unsustainable and sustainable or mixed equilibria, where both defectors and conformers coexist. Under bistability conditions, increasing time delays reduces the basin of attraction of the mixed equilibrium, thus resulting in abrupt regime shifts towards unsustainable pathways. Given recent evidence of large ecological relaxation rates, such results call for farsightedness and a better understanding of lag effects when studying the sustainability of coupled SESs.
Bacterial colonization stimulates a complex physiological response in the immature human intestinal epithelium
Authors: Hill David R. , Huang Sha , Nagy Melinda S. , Yadagiri Veda K. , Fields Courtney , Mukherjee Dishari , Bons Brooke , Dedhia Priya H. , Chin Alana M. , Tsai Yu-Hwai , Thodla Shrikar , Schmidt Thomas M. , Walk Seth , Young Vincent B. , Spence Jason R. 
Published: June 2017

AbstractThe human gastrointestinal tract is immature at birth, yet must adapt to dramatic changes such as oral nutrition and microbial colonization. The confluence of these factors can lead to severe inflammatory disease in premature infants; however, investigating complex environment-host interactions is diZcult due to limited access to immature human tissue. Here, we demonstrate that the epithelium of human pluripotent stem cell-derived human intestinal organoids is globally similar to the immature human epithelium and we utilize HIOs to investigate complex host-microbe interactions in this naïve epithelium. Our findings demonstrate that the immature epithelium is intrinsically capable of establishing a stable host-microbe symbiosis. Microbial colonization leads to complex contact and hypoxia driven responses resulting in increased antimicrobial peptide production, maturation of the mucus layer, and improved barrier function. These studies lay the groundwork for an improved mechanistic understanding of how colonization influences development of the immature human intestine.
Why human papillomavirus acute infections matter
Authors: Alizon Samuel , Murall Carmen Lía , Bravo Ignacio G. 
Published: June 2017

AbstractMost infections by human papillomaviruses (HPVs) are ‘acute’, that is non-persistent. Yet, for HPVs, as for many other oncoviruses, there is a striking gap between our detailed understanding of chronic infections and our limited data on the early stages of infection. Here we argue that studying HPV acute infections is necessary and timely. Focusing on early interactions will help explain why certain infections are cleared while others become chronic or latent. From a molecular perspective, descriptions of immune effectors and pro-inflammatory pathways during the initial stages of infections have the potential to lead to novel treatments or to improved handling algorithms. From a dynamical perspective, adopting concepts from spatial ecology, such as meta-populations or meta-communities, can help explain why HPV acute infections sometimes last for years. Furthermore, cervical cancer screening and vaccines impose novel iatrogenic pressures on HPVs, implying that anticipating any viral evolutionary response remain essential. Finally, hints at the associations between HPV acute infections and fertility deserve further investigation given their high worldwide prevalence. Overall, understanding asymptomatic and benign infections may be instrumental in reducing HPV virulence.
Biogeography & environmental conditions shape bacteriophage-bacteria networks across the human microbiome
Authors: Hannigan Geoffrey D , Duhaime Melissa B , Koutra Danai , Schloss Patrick D 
Published: June 2017

AbstractViruses and bacteria are critical components of the human microbiome and play important roles in health and disease. Most previous work has relied on studying bacteria and viruses independently, thereby reducing them to two separate communities. Such approaches are unable to capture how these microbial communities interact, such as through processes that maintain community robustness or allow phage-host populations to co-evolve. We implemented a network-based analytical approach to describe phage-bacteria network diversity throughout the human body. We built these community networks using a machine learning algorithm to predict which phages could infect which bacteria in a given microbiome. Our algorithm was applied to paired viral and bacterial metagenomic sequence sets from three previously published human cohorts. We organized the predicted interactions into networks that allowed us to evaluate phage-bacteria connectedness across the human body. We observed evidence that gut and skin network structures were person-specific and not conserved among cohabitating family members. High-fat diets appeared to be associated with less connected networks. Network structure differed between skin sites, with those exposed to the external environment being less connected and likely more susceptible to network degradation by microbial extinction events. This study quantified and contrasted the diversity of virome-microbiome networks across the human body and illustrated how environmental factors may influence phage-bacteria interactive dynamics. This work provides a baseline for future studies to better understand system perturbations, such as disease states, through ecological networks.Author SummaryThe human microbiome, the collection of microbial communities that colonize the human body, is a crucial component to health and disease. Two major components of the human microbiome are the bacterial and viral communities. These communities have primarily been studied separately using metrics of community composition and diversity. These approaches have failed to capture the complex dynamics of interacting bacteria and phage communities, which frequently share genetic information and work together to maintain ecosystem homestatsis (e.g. kill-the-winner dynamics). Removal of bacteria or phage can disrupt or even collapse those ecosystems. Relationship-based network approaches allow us to capture this interaction information. Using this network-based approach with three independent human cohorts, we were able to present an initial understanding of how phage-bacteria networks differ throughout the human body, so as to provide a baseline for future studies of how and why microbiome networks differ in disease states.