bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir: Drug Interactions With Antiretroviral Agents and Drugs for Substance Abuse
Authors: King Jennifer R. , Menon Rajeev M. 
Published: March 2017

AbstractAbbVie's 3 direct‐acting antiviral (3D) regimen containing ombitasvir, paritaprevir, ritonavir, and dasabuvir with and without ribavirin is approved for the treatment of chronic hepatitis C virus (HCV) genotype 1 infection. Safe and efficacious antiviral regimens resulting in minimal to no drug–drug interactions (DDIs) with antiretrovirals are needed to ensure that patients coinfected with HCV and the human immunodeficiency virus (HIV) achieve 12‐week sustained virologic response rates similar to HCV‐monoinfected patients. Also, the prevalence of injection drug use history is high in both monoinfected and HIV/HCV‐coinfected patients. This review summarizes results from phase 1 DDI studies of the 3D regimen and antiretrovirals or drugs to treat substance abuse. Data suggest the 3D regimen is a viable option for HIV/HCV‐coinfected patients on antiretroviral therapy containing tenofovir/emtricitabine, abacavir/lamivudine, dolutegravir, raltegravir, or atazanavir. HCV‐infected patients receiving medications for substance abuse, particularly methadone or buprenorphine/naloxone, can also be treated with the 3D regimen.
Mechanisms and Consequences of Drug‐Drug Interactions
Authors: Greenblatt David J. 
Published: March 2017

AbstractMedications used to treat human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections present a special challenge with respect to the management of potential and actual drug‐drug interactions (DDIs). The HIV and HCV treatments may interact with each other, and also interact with drugs of abuse and/or with medications used to treat substance abuse. Possible mechanisms of these DDIs generally include induction or inhibition of activity/expression of human cytochromes P450, glucuronosyl transferases, or energy‐dependent transport proteins. These DDIs can be complex and time‐dependent in nature. Because time and resources available for new drug development are necessarily limited, not all potential DDIs can be evaluated via clinical pharmacokinetic studies in the course of development of HIV, HCV, and substance abuse treatments. Strategies are needed to refine existing in vitro models and screening techniques to allow more efficient targeting of resources to those clinical studies having the highest impact in terms of enhancing medication effectiveness and patient safety.
Autotuning CUDA compiler parameters for heterogeneous applications using the OpenTuner framework
Authors: Bruel Pedro , Amarís Marcos , Goldman Alfredo 
Published: March 2017

SummaryA Graphics Processing Unit (GPU) is a parallel computing coprocessor specialized in accelerating vector operations. The enormous heterogeneity of parallel computing platforms justifies and motivates the development of automated optimization tools and techniques. The Algorithm Selection Problem consists in finding a combination of algorithms, or a configuration of an algorithm, that optimizes the solution of a set of problem instances. An autotuner solves the Algorithm Selection Problem using search and optimization techniques.In this paper, we implement an autotuner for the Compute Unified Device Architecture compiler's parameters using the OpenTuner framework. The autotuner searches for a set of compilation parameters that optimizes the time to solve a problem. We analyze the performance speedups, in comparison with high‐level compiler optimizations, achieved in three different GPU devices, for 17 heterogeneous GPU applications, 12 of which are from the Rodinia Benchmark Suite. The autotuner often beats the compiler's high‐level optimizations, but underperformed for some problems. We achieved over 2x speedup for Gaussian Elimination and almost 2x speedup for Heart Wall, both problems from the Rodinia Benchmark, and over 4x speedup for a matrix multiplication algorithm. Copyright © 2017 John Wiley & Sons, Ltd.
Zwitterionic Modification of Ultrasmall Iron Oxide Nanoparticles for Reduced Protein Corona Formation
Authors: Pombo‐García Karina , Rühl Carmen L. , Lam Raymond , Barreto José A. , Ang Ching‐Seng , Scammells Peter J. , Comba Peter , Spiccia† Leone , Graham Bim , Joshi Tanmaya , Stephan Holger 
Published: March 2017

AbstractPolyacrylic‐acid‐coated ultra‐small super‐paramagnetic iron oxide nanoparticles were surface‐modified with low‐molecular‐weight sulfobetaines or 3‐(diethylamino)propylamine in order to generate nanoparticles with zwitterionic character (ZW‐NPs). The ZW‐NPs proved highly resistant to serum protein corona formation in vitro, as revealed by atomic force microscopy, SDS‐PAGE and proteomics analysis, and exhibited low cytotoxicity towards A431 and HEK293 cells. The presence of unreacted carboxylic acid groups enabled additional functionalization with fluorescent (Cy5) and radioactive [64Cu–dmptacn; dmptacn=1,4‐bis(2‐pyridinylmethyl)‐1,4,7‐triazacyclononane] moieties. Overall, the ZW‐NPs represent promising platforms for the development of new multimodal diagnostic/therapeutic agents possessing “stealth” properties.
The Inverted U‐Shaped Relationship between Corporate Philanthropy and Spending on Research and Development: A Case of Complementarity and Competition Moderated by Firm Size and Visibility
Authors: Gao Yongqiang , Wu Jian , Hafsi Taïeb 
Published: March 2017

AbstractPrior studies on corporate social responsibility (CSR) and innovation suggest either a competing or a complementary relationship between CSR and spending on research and development (R&D) activities. In this study, we unravel this puzzle by theorizing an inverted U‐shaped relationship between CSR in general and corporate philanthropy (CP) in particular, and R&D spending. Drawing mainly on stakeholder theory, we suggest that CP, by securing stakeholders’ support differently at different levels of spending, would first increase and then reduce R&D spending. Evidence from Chinese publicly traded companies during 2006–2015 well supports our arguments. In addition, we find this inverse U‐shaped non‐linear relationship between CP and R&D spending to be strengthened by firm visibility and weakened by firm size. This study has important theoretical and practical implications. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment
ADMB: Application‐driven multihop broadcast for vehicular networks
Authors: Liu Fangqi , Liu Yanheng , Wang Jian , Deng Weiwen , Xu Shaoqing 
Published: March 2017

SummaryConsidering the strong correlation between packet's dissemination range and its originating application's benefit in vehicular networks, this paper introduces 2 new concepts of distance‐dependent application influence and time‐dependent application accuracy, both of which comprise the application profit. Then, we propose an application‐driven multihop broadcast (ADMB) method through hop‐by‐hop tradeoff between the application profit and network cost in deciding whether or not to relay the broadcast. The dynamic network states and elapsed broadcasting value are joined into the decision‐making process, by such way ADMB enables the cross‐layer joint optimization between application and network layers. Moreover, ADMB permits applications themselves to preferentially customize their desired dissemination distance and tolerant sensitivity to the time‐lag effect, which are characterized by influence coefficient and accuracy coefficient, respectively. Every relaying participant also could customize its priority consideration about application influence and accuracy as well as selfish extent in making decision. We perform extensive numerical calculations and simulations to investigate the applicability and use of ADMB against various combinations of application requirements and network parameters. The results show that ADMB can behave superiorly over the traditional fixed‐hop broadcast, fully use the restrictive network resources, and adaptively react to the time‐varying network context.
Birth order and recalled childhood gender nonconformity in Samoan men and fa'afafine
Authors: Semenyna Scott W. , VanderLaan Doug P. , Vasey Paul L. 
Published: March 2017

AbstractHaving a greater than average number of older biological brothers is a robust correlate of male androphilia (i.e., sexual attraction and arousal to adult males). Previous investigations have sought to understand whether this fraternal birth order (FBO) effect is also systematically related to recalled indicators of childhood gender nonconformity (CGN). However, these investigations have relied on data from low‐fertility Western populations in which expressions of femininity in male children are routinely stigmatized and consequently, suppressed. The present study examined the FBO effect (among other sibship characteristics) and recalled indicators of CGN in Samoa, a high‐fertility population, whose members are relatively tolerant of male femininity. Indeed, Samoans identify feminine androphilic males as belonging to an alternative gender category, known locally as fa'afafine. The present study compared the sibship characteristics of 231 fa'afafine and 231 opposite‐sex attracted men from Samoa, as well as how these characteristics related to recalled CGN. Results replicated the well‐established FBO effect for predicting male sexual orientation, with each older brother increasing the odds of being androphilic by 21%. However, no relationship was found between the number of older brothers (or other siblings) a participant had and their recalled CGN. Although fa'afafine reported significantly more CGN than Samoan men, CGN did not mediate the FBO effect, nor did the FBO effect and CGN interact to predict male sexual orientation. These findings are consistent with previous studies suggesting that the FBO effect is associated with male sexual orientation, but not childhood female‐typical gender expression among androphilic males.
Lipids in maternal diet influence yolk hormone levels and post‐hatch neophobia in the domestic chick
Authors: de Haas Elske N. , Calandreau Ludovic , Baéza Elisabeth , Chartrin Pascal , Palme Rupert , Darmaillacq Anne‐Sophie , Dickel Ludovic , Lumineau Sophie , Houdelier Cécilia , Denis Isabelle , Arnould Cécile , Meurisse Maryse , Bertin Aline 
Published: March 2017

AbstractWe assessed whether the ratio of dietary n‐6/n‐3 polyunsaturated fatty acids (PUFA) during egg formation engenders transgenerational maternal effects in domestic chicks. We analyzed yolk lipid and hormone concentrations, and HPA‐axis activity in hens fed a control diet (high n‐6/n‐3 ratio) or a diet enriched in n‐3 PUFAs (low n‐6/n‐3 ratio) for 6 consecutive weeks. Their chicks were tested for neophobia during the first week of life. We found higher corticosterone metabolites in droppings of hens fed the diet enriched in n‐3 and significantly higher concentrations of yolk progesterone, androstenedione, and estradiol in their eggs compared to controls. Chicks of hens fed the n‐3 enriched diet showed a lower body mass at hatch than controls and expressed higher neophobia when exposed to a novel object. These results add support to the hypothesis that the nutritional state of female birds produces variation in yolk hormone levels and engender maternal effects.
Parasympathetic reactivity and disruptive behavior problems in young children during interactions with their mothers and other adults: A preliminary investigation
Authors: Cooper‐Vince Christine E. , DeSerisy Mariah , Cornacchio Danielle , Sanchez Amanda , McLaughlin Katie A. , Comer Jonathan S. 
Published: March 2017

AbstractParasympathetic nervous system influences on cardiac functions—commonly indexed via respiratory sinus arrhythmia (RSA)—are central to self‐regulation. RSA suppression during challenging emotional and cognitive tasks is often associated with better emotional and behavioral functioning in preschoolers. However, the links between RSA suppression and child behavior across various challenging interpersonal contexts remains unclear. The present study experimentally evaluated the relationship between child RSA reactivity to adult (mother vs. study staff) direction and disruptive behavior problems in children ages 3–8 with varying levels of disruptive behavior problems (N = 43). Reduced RSA suppression in the context of mothers’ play‐based direction was associated with more severe child behavior problems. In contrast, RSA suppression in the context of staff play‐based direction was not associated with behavior problems. Findings suggest that the association between RSA suppression and child behavior problems may vary by social context (i.e., mother vs. other adult direction‐givers). Findings are discussed in regard to RSA as an indicator of autonomic self‐regulation that has relevance to child disruptive behavior problems.
Hydrological‐niche models predict water plant functional group distributions in diverse wetland types
Authors: Deane David C. , Nicol Jason M. , Gehrig Susan L. , Harding Claire , Aldridge Kane T. , Goodman Abigail M. , Brookes Justin D. 
Published: March 2017

AbstractHuman use of water resources threatens environmental water supplies. If resource managers are to develop policies that avoid unacceptable ecological impacts, some means to predict ecosystem response to changes in water availability is necessary. This is difficult to achieve at spatial scales relevant for water resource management because of the high natural variability in ecosystem hydrology and ecology. Water plant functional groups classify species with similar hydrological niche preferences together, allowing a qualitative means to generalize community responses to changes in hydrology. We tested the potential for functional groups in making quantitative prediction of water plant functional group distributions across diverse wetland types over a large geographical extent. We sampled wetlands covering a broad range of hydrogeomorphic and salinity conditions in South Australia, collecting both hydrological and floristic data from 687 quadrats across 28 wetland hydrological gradients. We built hydrological‐niche models for eight water plant functional groups using a range of candidate models combining different surface inundation metrics. We then tested the predictive performance of top‐ranked individual and averaged models for each functional group. Cross validation showed that models achieved acceptable predictive performance, with correct classification rates in the range 0.68–0.95. Model predictions can be made at any spatial scale that hydrological data are available and could be implemented in a geographical information system. We show the response of water plant functional groups to inundation is consistent enough across diverse wetland types to quantify the probability of hydrological impacts over regional spatial scales.
A global database of nitrogen and phosphorus excretion rates of aquatic animals
Authors: Vanni Michael J. , McIntyre Peter B. , Allen Dennis , Arnott Diane L. , Benstead Jonathan P. , Berg David J. , Brabrand Åge , Brosse Sébastien , Bukaveckas Paul A. , Caliman Adriano , Capps Krista A. , Carneiro Luciana S. , Chadwick Nanette E. , Christian Alan D. , Clarke Andrew , Conroy Joseph D. , Cross Wyatt F. , Culver David A. , Dalton Christopher M. , Devine Jennifer A. , Domine Leah M. , Evans‐White Michelle A. , Faafeng Bjørn A. , Flecker Alexander S. , Gido Keith B. , Godinot Claire , Guariento Rafael D. , Haertel‐Borer Susanne , Hall Robert O. , Henry Raoul , Herwig Brian R. , Hicks Brendan J. , Higgins Karen A. , Hood James M. , Hopton Matthew E. , Ikeda Tsutomu , James William F. , Jansen Henrice M. , Johnson Cody R. , Koch Benjamin J. , Lamberti Gary A. , Lessard‐Pilon Stephanie , Maerz John C. , Mather Martha E. , McManamay Ryan A. , Milanovich Joseph R. , Morgan Dai K. J. , Moslemi Jennifer M. , Naddafi Rahmat , Nilssen Jens Petter , Pagano Marc , Pilati Alberto , Post David M. , Roopin Modi , Rugenski Amanda T. , Schaus Maynard H. , Shostell Joseph , Small Gaston E. , Solomon Christopher T. , Sterrett Sean C. , Strand Øivind , Tarvainen Marjo , Taylor Jason M. , Torres‐Gerald Lisette E. , Turner Caroline B. , Urabe Jotaro , Uye Shin‐Ichi , Ventelä Anne‐Mari , Villeger Sébastien , Whiles Matt R. , Wilhelm Frank M. , Wilson Henry F. , Xenopoulos Marguerite A. , Zimmer Kyle D. 
Published: March 2017

AbstractAnimals can be important in modulating ecosystem‐level nutrient cycling, although their importance varies greatly among species and ecosystems. Nutrient cycling rates of individual animals represent valuable data for testing the predictions of important frameworks such as the Metabolic Theory of Ecology (MTE) and ecological stoichiometry (ES). They also represent an important set of functional traits that may reflect both environmental and phylogenetic influences. Over the past two decades, studies of animal‐mediated nutrient cycling have increased dramatically, especially in aquatic ecosystems. Here we present a global compilation of aquatic animal nutrient excretion rates. The dataset includes 10,534 observations from freshwater and marine animals of N and/or P excretion rates. These observations represent 491 species, including most aquatic phyla. Coverage varies greatly among phyla and other taxonomic levels. The dataset includes information on animal body size, ambient temperature, taxonomic affiliations, and animal body N:P. This data set was used to test predictions of MTE and ES, as described in Vanni and McIntyre (2016; Ecology DOI: 10.1002/ecy.1582).
Plasticity in nitrogen uptake among plant species with contrasting nutrient acquisition strategies in a tropical forest
Authors: Andersen Kelly M. , Mayor Jordan R. , Turner Benjamin L. 
Published: March 2017

AbstractNitrogen (N) availability influences the productivity and distribution of plants in tropical montane forests. Strategies to acquire soil N, such as direct uptake of organic compounds or associations with root symbionts to enhance N acquisition in exchange for carbon (C), may facilitate plant species coexistence and ecosystem N retention. Alternatively, rapid microbial turnover of soil N forms in tropical soils might promote flexible plant N‐uptake strategies and mediate species coexistence. We tested whether sympatric plant species with different root symbiont associations, and therefore potentially different nutrient acquisition strategies, partition chemical forms of N or show plasticity in N uptake in a tropical pre‐montane forest in Panama. We traced the movement of three15N forms into soil pools, microbes, and seedlings of eleven species differing in root traits. Seedlings were grown in a split‐plot field transplant experiment, with plots receiving equimolar mixtures of ammonium, nitrate, and glycine, with one form isotopically labeled in each block. After 48 h, more15N was recovered in microbes than in plants, while all pools (extractable organic and inorganic N, microbial biomass, and leaves) contained greater amounts of15N from nitrate than from ammonium or glycine. Furthermore,13C from dual‐labeled glycine was not recovered in the leaves of any seedling, suggesting the studied species do not directly take up organic N or transform organic N prior to translocation to leaves. Nitrogen uptake differed by root symbiont group only for nitrate, with greater15N recovery in plants with arbuscular mycorrhizal (AM) associations or proteoid roots compared to orchids. Some root trait groups differed in15N recovery among N forms, with greater nitrate uptake than ammonium or glycine by AM‐associated and N2‐fixing plants. However, only five of eleven species showed differences in uptake among N forms. These results indicate flexibility in uptake of N forms in tropical plants across root trait groups, with only a few species displaying weak preferences for a specific N form.
Bilateral analgesic effects of abobotulinumtoxinA (Dysport®) following unilateral administration in the rat
Authors: Favre‐Guilmard C. , Chabrier P.‐E. , Kalinichev M. 
Published: March 2017

AbstractBackgroundIn addition to inhibition of muscle and glandular hyperactivity, botulinum neurotoxin (BoNT) type A also interferes with pain processing. Previously, in a rat model of paclitaxel‐induced polyneuropathy, abobotulinumtoxinA (aboBoNT‐A) elicited analgesic effects not only in the injected paw, but also in the contralateral, non‐injected paw.MethodsHere, we assessed bilateral analgesic effects of unilateral aboBoNT‐A in several chronic pain models in Sprague‐Dawley rats. Effects of aboBoNT‐A on the paw withdrawal threshold in response to mechanical pressure was assessed in models of streptozotocin‐induced diabetic polyneuropathy, chronic constriction injury (CCI)‐associated mononeuropathy, and bilateral carrageenan‐induced inflammatory pain.ResultsIn diabetic polyneuropathy, aboBoNT‐A (15, 20 U/kg) reversed hyperalgesia in the toxin‐injected and non‐injected paws. In unilateral CCI‐exposed animals, 20 U/kg aboBoNT‐A given ipsilateral to the injury reversed mechanical hyperalgesia, while 30 U/kg aboBoNT‐A given contralateral to the injury had no effect. In carrageenan‐induced bilateral inflammatory pain, aboBoNT‐A (20, 30 U/kg) reversed hyperalgesia in both toxin‐injected and non‐injected paws.DiscussionThese results suggest that unilateral administration of aboBoNT‐A results in bilateral reduction in mechanical hyperalgesia across neuropathic and inflammatory pain conditions, bilateral activation of sensory neurons being prerequisite for its expression. Future studies involving effects on other sensory modalities as well as those evaluating diffusion and migration of the toxin away from the injection site can shed light on mechanisms of this phenomenon.SignificanceThe results expand evidence on bilateral analgesic effects of aboBoNT‐A following unilateral administration across pain modalities, as the phenomenon is seen in more than one model of polyneuropathy as well as in a model of chronic inflammatory pain when the latter is rendered bilateral. The mechanism of bilateral analgesic effects of aboBoNT‐A may require activation of the peripheral sensory neurons and involve retrograde axonal transport of the toxin into the spinal cord.
Experimental assessment of contact forces on a rigid base following footing uplift
Authors: Chen Yuanzhi , Larkin Tam , Chouw Nawawi 
Published: March 2017

SummaryA number of investigations in the recent decades have shown that footing uplift can reduce the seismic loading on a structure. Guidelines to design a structure with seismic uplift capability have been proposed. However, these studies mainly focus on the structural response and neglect the impact forces on the footing from re‐contact between the footing and the supporting medium. A small number of computational studies of the induced forces on the footing have been performed. This paper presents the results of free vibrations and shake table tests on a single degree‐of‐freedom model of a bridge pier with footing uplift on a rigid base. Two support conditions are considered, that is, footing fixed to the base and footing free to uplift on a rigid base. Load cells were placed at the interface of the footing and rigid base to measure the contact forces during structural vibration. The footing responses of both flexible and rigid structures due to free vibration are compared. The results show that the flexibility of the structure has significant effects on footing uplift duration and amplitude and reduces the contact force, in some cases very significantly. The flexible structure was also subjected to harmonic base excitations. It is found that varying the characteristics of the excitation changes the uplift amplitude but does not affect the contact force significantly. Copyright © 2017 John Wiley & Sons, Ltd.