bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Reservoir of rage swamps Wall St”
Authors: Gregoriou Christiana , Paterson Laura L. 
Published: September 2017

AbstractOriginating on New York’s Wall Street, the Occupy movement was “an international network of protests against social and economic inequality that began in [September] 2011 in response to the downturn of 2008” (Thorson et al. 2013, 427). Whilst there has been research on online activity in relation to Occupy, the scope of linguistic analysis to date has been somewhat narrow. Furthermore, the focus on new media has indirectly led to an absence of analysis of institutionally-endorsed traditional media texts. We adopt a mixed-method approach of corpus analysis and discourse analysis of national newspaper articles to answer questions such as ‘Is Occupy associated with a semantic field of violence and aggression?’ and ‘Who is represented as having agency?’ Our results indicate that, in our small corpus of media texts, Occupy and its supporters were predominantly portrayed negatively at the movement’s height; even though protesters are reported to have been peaceful in their majority, the English-speaking media we analysed still aligns them with language suggestive of aggression, conflict and even violence.
On the mechanisms of protein interactions: predicting their affinity from unbound tertiary structures
Authors: Marín-López Manuel Alejandro , Planas-Iglesias Joan , Aguirre-Plans Joaquim , Bonet Jaume , Garcia-Garcia Javier , Fernandez-Fuentes Narcis , Oliva Baldo 
Published: September 2017

Abstract

Motivation
The characterization of the protein–protein association mechanisms is crucial to understanding how biological processes occur. It has been previously shown that the early formation of non-specific encounters enhances the realization of the stereospecific (i.e. native) complex by reducing the dimensionality of the search process. The association rate for the formation of such complex plays a crucial role in the cell biology and depends on how the partners diffuse to be close to each other. Predicting the binding free energy of proteins provides new opportunities to modulate and control protein–protein interactions. However, existing methods require the 3D structure of the complex to predict its affinity, severely limiting their application to interactions with known structures.

Results
We present a new approach that relies on the unbound protein structures and protein docking to predict protein–protein binding affinities. Through the study of the docking space (i.e. decoys), the method predicts the binding affinity of the query proteins when the actual structure of the complex itself is unknown. We tested our approach on a set of globular and soluble proteins of the newest affinity benchmark, obtaining accuracy values comparable to other state-of-art methods: a 0.4 correlation coefficient between the experimental and predicted values of ΔG and an error &lt; 3 Kcal/mol.

Availability and implementation
The binding affinity predictor is implemented and available at http://sbi.upf.edu/BADock and https://github.com/badocksbi/BADock.

Supplementary information
Supplementary data are available at Bioinformatics online.
Integrating reflexes with physiological measures to evaluate coastal shark stress response to capture
Authors: Jerome J M , Gallagher A J , Cooke S J , Hammerschlag N 
Published: September 2017

AbstractIn both commercial and recreational fisheries, sharks are captured and released alive to comply with regulations or due to low economic value or voluntary conservation ethic. As a result, understanding the physiological and behavioural responses of sharks to capture stress is important for determining subsequent effects of fisheries interactions on a species-specific basis, as well as for identifying factors that influence mortality. Here, we employed a suite of conventional blood physiology endpoints (glucose, lactate, and haematocrit) integrated with assessments of reflex impairment on blacktip (Carcharhinus limbatus), great hammerhead (Sphyrna mokarran), nurse (Ginglymostoma cirratum) and sandbar sharks (Carcharhinus plumbeus) captured via experimental drumline gear. We documented a wide range of species-specific differences in all parameters assessed, with nurse sharks consistently having the lowest relative levels of physiological disturbance and reflex impairment; and with great hammerheads exhibiting the highest level of physiological disturbance and reflex impairment, suggesting higher vulnerability to fishing. In general, increases in lactate were positively associated with hook time and correlated with reflex impairment assessment. Moreover, reflex indices showed significant impairment with hook time, with the “jaw” reflex emerging as the most potential predictor of disturbance. Our study results connect previously reported species-specific at-vessel and post-release mortality rates to their physiological disturbance and reflex impairment.
Seasonal Influenza Forecasting in Real Time Using the Incidence Decay With Exponential Adjustment Model
Authors: Nasserie Tahmina , Tuite Ashleigh R , Whitmore Lindsay , Hatchette Todd , Drews Steven J , Peci Adriana , Kwong Jeffrey C , Friedman Dara , Garber Gary , Gubbay Jonathan , Fisman David N 
Published: September 2017

AbstractBackgroundSeasonal influenza epidemics occur frequently. Rapid characterization of seasonal dynamics and forecasting of epidemic peaks and final sizes could help support real-time decision-making related to vaccination and other control measures. Real-time forecasting remains challenging.MethodsWe used the previously described “incidence decay with exponential adjustment” (IDEA) model, a 2-parameter phenomenological model, to evaluate the characteristics of the 2015–2016 influenza season in 4 Canadian jurisdictions: the Provinces of Alberta, Nova Scotia and Ontario, and the City of Ottawa. Model fits were updated weekly with receipt of incident virologically confirmed case counts. Best-fit models were used to project seasonal influenza peaks and epidemic final sizes.ResultsThe 2015–2016 influenza season was mild and late-peaking. Parameter estimates generated through fitting were consistent in the 2 largest jurisdictions (Ontario and Alberta) and with pooled data including Nova Scotia counts (R0 approximately 1.4 for all fits). Lower R0 estimates were generated in Nova Scotia and Ottawa. Final size projections that made use of complete time series were accurate to within 6% of true final sizes, but final size was using pre-peak data. Projections of epidemic peaks stabilized before the true epidemic peak, but these were persistently early (~2 weeks) relative to the true peak.ConclusionsA simple, 2-parameter influenza model provided reasonably accurate real-time projections of influenza seasonal dynamics in an atypically late, mild influenza season. Challenges are similar to those seen with more complex forecasting methodologies. Future work includes identification of seasonal characteristics associated with variability in model performance.
Tuberculosis Patients Who Are A Potential Source for Unprotected Exposure in Health Care Systems: A Multicenter Case Control Study
Authors: Cadena Jose , Castro-Pena Norys A , Javeri Heta , Hernandez Brian , Michalek Joel , Arzola Ana Fuentes , Shroff Miloni , Jinadatha Chetan , Valero Gustavo , Bowling Jason , Przykucki Jean , Adams Michele , Jorgensen James , Patterson Jan E , Sreeramoju Pranavi 
Published: September 2017

Abstract

Setting
Five health care systems in Texas.

Objective
To describe the epidemiology of inadequate isolation for pulmonary tuberculosis leading to tuberculosis (TB) exposures from confirmed TB patients and the patient factors that led to the exposures.

Design
A retrospective cohort and case-control study of adult patients with TB resulting in exposures (cases) vs those TB patients who did not result in exposures (controls) during January 2005 to December 2012.

Results
There were 335 patients with pulmonary TB disease, 199 cases and 136 controls. There was no difference between groups in age (46 ± 14.6 vs 45 ± 17 years; P &gt; .05), race, or substance abuse. Cases were more likely to be transplant recipients (adjusted odds ratio [AOR], 18.90; 95% CI, 1.9–187.76), have typical TB chest radiograph (AOR, 2.23; 95% CI, 1.1–4.51), and have positive acid-fast bacilli stains (AOR, 2.36; 95% CI, 1.31–4.27). Cases were less likely to have extrapulmonary disease (AOR, 0.47; 95% CI, 0.24–0.95).

Conclusions
TB exposure resulting from inadequate isolation is frequent in health care settings. Extrapulmonary involvement resulted in earlier airborne isolation. Being a transplant recipient, having chest radiograph findings typical for TB, and sputum positivity acid-fast bacilli upon staining were associated with increased risk of inadequate isolation.
Two Cases of Severe Tick-Borne Encephalitis in Rituximab-Treated Patients in Germany: Implications for Diagnosis and Prevention
Authors: Steininger Philipp A , Bobinger Tobias , Dietrich Wenke , Lee De-Hyung , Knott Michael , Bogdan Christian , Korn Klaus , Lang Roland 
Published: September 2017

Abstract
Rituximab (RTX) has become a standard therapy for certain B cell malignancies and autoimmune diseases. We report 2 RTX-treated patients who developed severe tick-borne encephalitis virus (TBEV) infection. The inability to generate new antibody responses renders RTX-treated patients susceptible to TBEV, impedes laboratory diagnosis, and necessitates preventive vaccination in endemic areas.
A Review of Oxygen Physiology and Appropriate Management of Oxygen Levels in Premature Neonates
Authors: Kayton Allyson , Timoney Paula , Vargo Lyn , Perez Jose A. 
Published: September 2017

Background:
Although oxygen is the most widely used therapeutic agent in neonatal care, optimal oxygen management remains uncertain.

Purpose:
We reviewed oxygen physiology and balance, key studies evaluating oxygen saturation targets, and strategies for oxygen use in the neonatal intensive care unit.

Results:
Oxygen is a potent vasodilator involved in the transition at birth to breathing. Supplemental oxygen is administered to reverse/prevent hypoxia; however, excessive oxygen can be toxic owing to the formation of reactive oxygen species. Current neonatal resuscitation guidelines recommend using room air for term infants in need of support, with titration to achieve oxygen saturation levels similar to uncompromised term infants. In premature infants, targeting a higher oxygen saturation range (eg, 91%-95%) may be safer than targeting a lower range (eg, 85%-89%), but more evidence is needed. In combined analyses, lower oxygen saturation levels increased mortality, suggesting that the higher target may be safer, but higher targets are associated with an increased risk of developing disorders of oxidative stress.

Implications for Practice:
Need for supplemental oxygen should be assessed according to the American Heart Association guidelines. If appropriate, oxygen should be administered using room air, with the goal of preventing hypoxia and avoiding hyperoxia. Use of oximeter alarms may help achieve this goal. Pulmonary vasodilators may improve oxygenation and reduce supplemental oxygen requirements.

Implications for Research:
Implementation of wider target ranges for oxygen saturation may be more practical and lead to improved outcomes; however, controlled trials are necessary to determine the impact on mortality and disability.
Do Children Who Sustain Traumatic Brain Injury in Early Childhood Need and Receive Academic Services 7 Years After Injury?
Authors: Kingery Kathleen M. , Narad Megan E. , Taylor H. Gerry , Yeates Keith Owen , Stancin Terry , Wade Shari L. 
Published: September 2017

ABSTRACT:

Objective:
To examine the prevalence of academic need, academic service utilization, and unmet need as well as factors associated with academic service utilization 6.8 years after traumatic brain injury (TBI) in early childhood.

Methods:
Fifty-eight (16 severe, 14 moderate, 28 complicated mild) children with TBI and 72 children with orthopedic injury (OI) completed the long-term follow-up 6.8 years after injury in early childhood (ages 3–7 years). Injury group differences in rates of need for academic services, academic service utilization, and unmet need as well as factors associated with service utilization and unmet need were examined.

Results:
Students with moderate and severe TBI had significantly greater rates of need than those with OI. A greater proportion of the severe TBI sample was receiving academic services at long-term follow-up than the OI and complicated mild groups however, among those with an identified need, injury group did not affect academic service utilization. Below average IQ/achievement scores was the only area of need predictive of academic service utilization. Rates of unmet need were high and similar across injury groups (46.2%–63.6%).

Conclusion:
The need for academic services among patients who sustained a TBI during early childhood remains high 6.8 years post injury. Findings underscore the importance of continued monitoring of behaviors and academic performance in students with a history of early childhood TBI. This may be especially true among children with less severe injuries who are at risk for being underserved.
Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism
Authors: Mandrup Camilla M. , Egelund Jon , Nyberg Michael , Enevoldsen Lotte Hahn , Kjær Andreas , Clemmensen Andreas E. , Christensen Anders Nymark , Suetta Charlotte , Frikke-Schmidt Ruth , Steenberg Dorte Enggaard , Wojtaszewski Jørgen F.P. , Hellsten Ylva , Stallknecht Bente M. 
Published: September 2017

Abstract

Objective:
To investigate peripheral insulin sensitivity and skeletal muscle glucose metabolism in premenopausal and postmenopausal women, and evaluate whether exercise training benefits are maintained after menopause.

Methods:
Sedentary, healthy, normal-weight, late premenopausal (n = 21), and early postmenopausal (n = 20) women were included in a 3-month high-intensity exercise training intervention. Body composition was assessed by magnetic resonance imaging and dual-energy x-ray absorptiometry, whole body glucose disposal rate (GDR) by hyperinsulinemic euglycemic clamp (40 mU/m2/min), and femoral muscle glucose uptake by positron emission tomography/computed tomography, using the glucose analog fluorodeoxyglucose, expressed as estimated metabolic rate (eMR). Insulin signaling was investigated in muscle biopsies.

Results:
Age difference between groups was 4.5 years, and no difference was observed in body composition. Training increased lean body mass (estimate [95% confidence interval] 0.5 [0.2-0.9] kg, P < 0.01) and thigh muscle mass (0.2 [−0.1 to 0.6] kg, P < 0.01), and decreased fat percentage (1.0 [0.5-1.5]%, P < 0.01) similarly in the two groups. The postmenopausal women had lower eMR in vastus lateralis muscle than the premenopausal women (−14.0 [−26.0 to −2.0] μmol/min/kg, P = 0.02), and tended to have lower eMR in femoral muscles (−11.2 [−22.7 to 0.4] μmol/min/kg, P = 0.06), and also GDR (−59.3 [−124.8 to 6.3] mg/min, P = 0.08), but increased similarly in both groups with training (eMR vastus lateralis muscle: 27.8 [19.6-36.0] μmol/min/kg, P < 0.01; eMR femoral muscle: 20.0 [13.1-26.7] μmol/min/kg, P < 0.01, respectively; GDR: 43.6 [10.4-76.9] mg/min, P = 0.01). Potential mechanisms underlying the training-induced increases in insulin sensitivity included increased expression of hexokinase (19.2 [5.0-24.7] AU, P = 0.02) and glycogen synthase (32.4 [15.0-49.8] AU, P < 0.01), and also increased insulin activation of Akt2 (20.6 [3.4-29.0], P = 0.03) and dephosphorylation of glycogen synthase (−41.8 [−82.9 to −0.7], P = 0.05).

Conclusions:
Insulin sensitivity was reduced in early postmenopausal women. However, postmenopausal women increased peripheral insulin sensitivity, skeletal muscle insulin-stimulated glucose uptake, and skeletal muscle mass to the same extent as premenopausal women after 3 months of high-intensity exercise training.
Diversity and Inclusion in Plastic Surgery Education: A National Survey by the American Council of Academic Plastic Surgeons
Authors: Obeid Sara , Fanning Alex , Hultman C. Scott 
Published: September 2017

Introduction:
To date, there have been few studies in the field of plastic surgery examining the knowledge, attitudes, and behavior of educators and residents regarding diversity and inclusion, especially for the purposes of enhancing resident education, improving diversity efforts, and addressing health care disparities.

Methods:
An anonymous survey was provided electronically to a total of 462 American Council of Academic Plastic Surgeon members and 91 program coordinators (PCs), and 1,029 plastic surgery residents at 91 institutions across the United States. We analyzed the responses from PCs and program directors (PDs).

Results:
We collected responses from 34 institutions (37%), and 16.8% of American Council of Academic Plastic Surgeon members including 34 PCs and 44 PDs. We found that PDs were more likely to be male (86%) and above the age of 40 years (97%) compared with PCs (5% male and 61% above 40 years). Both groups were majority White. Fifty-nine percentage of PDs have a parent/guardian who attained a graduate degree versus 15% of PCs. Forty-eight percentage of PDs speak another language compared with 16% of PCs. More importantly, 95% of PDs had an opportunity to engage in diversity and inclusion-related activities in the last 6 months as compared with 43% of PCs; however, we did not find a statistical difference based on knowledge of increasing institutional capacity of diversity and inclusion between the 2 groups. PCs were more likely to witness discrimination (64%) than PDs (40%) in the health care setting, with body type/weight emerging as the most common type of discrimination. Very few respondents (10%) indicated they discriminated against others.

Conclusions:
Plastic surgery educators are committed to diversity and inclusion. Improvements can be made by incorporating PCs more frequently in activities related to the topic along with focused training on improving diversity on an institutional rather than individual level. Our study suggests body type/weight is the most common type of discrimination witnessed by the entire cohort and that diversity and inclusion remains a sensitive topic.
Autoimmune Syndrome Induced by Adjuvants (ASIA) after Silicone Breast Augmentation Surgery
Authors: Nunes e Silva Daniel , Gründler Cíntia , Spengler Maria das Graças de Melo Teixeira , Horimoto Alex Magno Coelho , Machado Mariana Albuquerque , Frazão Isadora Carvalho , Takita Luiz Carlos 
Published: September 2017

Summary:
Generally, the main complications of silicone implantation are local symptoms. However, some patients develop late-onset systemic symptoms often associated with a rare form of hyperactive immune response, as part of a syndrome known as autoimmune syndrome induced by adjuvants (ASIA). Reported cases of ASIA have shown resolution with explantation, but not with immunomodulatory therapy. In this report, we described a case of a previously healthy 23-year-old woman, who has undergone silicone breast implant augmentation, for aesthetic reasons, and developed localized cutaneous impairment 3 years postsurgery. She received a diagnosis of ASIA with a new presentation: Lupus-like manifestation through localized cutaneous impairment. This patient’s symptoms were managed without the need for surgical intervention, which has not been previously reported, because the patient did not want an explantation for aesthetic reasons. The patient was started on hydroxychloroquine, 400 mg per day, and remains asymptomatic after 2 years of treatment. The exact predisposition to ASIA is still unknown. Without implant explantation and with immunomodulatory treatment, this patient’s condition substantially improved. Based on our current understanding of this disease, it might not be prudent to indicate breast augmentation with silicone implants in patients with documented autoimmune reaction to an adjuvant, an established autoimmune condition, or genetic predisposition. However, if a patient does develop silicone-induced ASIA, explantation is no longer the only successfully reported option, as these symptoms can be managed with immune suppression.
Early Detection of Pancreatic Cancer
Authors: Kenner Barbara J. , Go Vay Liang W. , Chari Suresh T. , Goldberg Ann E. , Rothschild Laura J. 
Published: September 2017

Abstract
A diagnosis of pancreatic cancer is devastating owing to its poor prognosis, with a 5-year survival rate of only 9%. Currently, most individuals are diagnosed at a late stage when treatment options are limited. Early detection of pancreatic cancer provides the greatest hope for making substantial improvements in survival. The Kenner Family Research Fund in partnership with the American Pancreatic Association has sponsored a series of fora to stimulate discussion and collaboration on early detection of pancreatic cancer. At the first forum in 2014, “Early Detection of Sporadic Pancreatic Cancer Summit Conference,” a strategic plan was set forth by an international group of interdisciplinary scientific representatives and subsequently The Strategic Map for Innovation was generated. The current conference report is the third forum in the series, “Early Detection of Pancreatic Cancer: The Role of Industry in the Development of Biomarkers,” which was held in Boston, Massachusetts, on October 27, 2016. This report provides an overview of examples of innovative initiatives by industry and confirms the critical need for collaboration among industry, government, research institutions, and advocacy groups in order to make pancreatic cancer more easily detectable in its earlier stages, when it is more treatable.
Validity of the General Movement Optimality List in Infants Born Preterm
Authors: Ustad Tordis , Evensen Kari Anne I. , Bertoncelli Natascia , Frassoldati Rossella , Ferrari Fabrizio 
Published: September 2017

Purpose:
To examine concurrent and predictive validity of the optimality list “Detailed Assessment of General Movements (GMs) During Preterm and Term Age.”

Methods:
Video clips of general movements were analyzed for 20 infants born preterm without severe brain lesions. Concurrent validity of the optimality list compared with the General Movement Assessment (GMA) was examined. The General Movement Optimality Scores (GMOSs) between infants with normal and poor repertoire GMA were examined. Estimates of diagnostic accuracy were calculated.

Results:
The GMOS correlated with the GMA and differed between infants with normal and poor repertoire GMA. The area under the curve was below 0.53 with respect to normal or abnormal general movements at 3 months' corrected age.

Conclusions:
Concurrent validity of the optimality list was moderate to high compared with the GMA, but its predictive validity for general movements at 3 months' corrected age was low.