bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness and Safety of Acitretin in Children with Plaque Psoriasis: A Multicenter Retrospective Analysis
Authors: Di Lernia Vito , Bonamonte Domenico , Lasagni Claudia , Belloni Fortina Anna , Cambiaghi Stefano , Corazza Monica , Di Nuzzo Sergio , Gisondi Paolo , Panzone Michele , Guarneri Claudio , Neri Iria 
Published: July 2016

AbstractBackgroundAcitretin is licensed for and is most commonly used to treat psoriasis. Little information exists about its efficacy and safety in childhood and adolescent psoriasis.MethodsRetrospective analysis of a group of children and adolescents (<17 years of age) with moderate to severe plaque psoriasis treated with acitretin between 2010 and 2014 at Italian dermatology clinics. Patients were identified through databases or registries.ResultsThe study population consisted of 18 patients with a median age of 9.5 years at the start of therapy. The median maintenance dosage per day was 0.41 mg/kg. Eight patients (44.4%) achieved complete clearance or good improvement of their psoriasis, defined as improvement from baseline of 75% or more on the Psoriasis Area and Severity Index at week 16. Three had three or more courses of treatment with short disease‐free intervals. In three patients, acitretin treatment was ongoing at the time of data collection. The mean total duration of treatment in responders was 22.7 months. One patient discontinued treatment because of arthralgia. The remaining nine patients (50%) discontinued treatment because it was ineffective. Mucocutaneous adverse effects occurred in all patients, but did not affect therapy maintenance.ConclusionsIn this retrospective case series, acitretin was a moderately effective, well‐tolerated treatment in children with moderate to severe plaque psoriasis. Given the small number of patients, statements about long‐term safety are not possible.
Provider‐Identified Barriers to Cervical Cancer Screening and Perceptions Toward Self‐Collection of Human Papillomavirus in Southwest Virginia
Authors: Garcia Christine , Lothamer Heather , Mitchell Emma McKim 
Published: July 2016

AbstractObjectiveTo explore health care workers identified barriers to cervical cancer screening in rural Southwest Virginia.Design and SampleA descriptive study utilizing telephone‐based structured interviews and conventional content analysis. All free and federally funded health clinics within a 75 mile radius of Virginia's health Districts 1, 2, and 3 were contacted for participation in the study.MeasuresOrganizational information such as composition of clinical staff, services provided, cost of services, recorded compliance with current guidelines, and assessed individual barriers to accessing screening within the community.ResultsWith a 27% response rate, all but one clinic offered cervical cancer screening. The most common barriers to cervical cancer screening identified were lack of education and cost. The most important efforts to detect unscreened women and increase screening would involve clinic‐based tracking, education and advertisements. Seventy percent of respondents felt that self‐collection of HPV would be at least somewhat acceptable in their communities.ConclusionsPublic health nursing implications for the barriers of lack of education and high cost were found in this study. In Southwest Virginia, self‐collection of HPV was perceived as acceptable by health care workers in the community, and might represent an avenue for increased outreach and education.
An Overview of Mahābhārata Scholarship: A Perspective on the State of the Field
Authors: Sullivan Bruce M. 
Published: July 2016

AbstractMahābhārata (Mbh) studies are a vibrant field of academic study in which many scholars contribute to our understanding of one of the world's most fascinating literary achievements. Works here discussed include monographs and articles in English that represent the most significant efforts in our understanding of this text in recent years, as well as examples of fiction based on the h that demonstrate its ongoing appeal.
Pain and alcohol consumption among older adults: findings from the World Health Organization Study on global AGEing and adult health, Wave 1
Authors: Ahangari Alebtekin , Stewart Williams Jennifer , Myléus Anna 
Published: July 2016

AbstractObjectiveTo investigate cross‐sectional associations between self‐reported recent pain and alcohol use/abstinence, and previous‐day pain and previous‐week alcohol consumption in adults aged 50 + in six low‐ and middle‐income countries (LMICs).MethodsThe WHO Study on global AGEing and adult health (SAGE) Wave 1 (2007–2010) in China, Ghana, India, Mexico, Russia and South Africa is the data source. Prevalence of alcohol use/abstinence is reported by previous‐day and previous‐month pain. Multinomial logistic regressions (crude and adjusted for sex and country) tested associations between recent pain and alcohol use in the pooled multicountry sample.ResultsAcross the six SAGE countries, about one‐third of respondents reported alcohol use, being highest in Russia (74%) and lowest in India (16%). Holding the effects of sex and country constant, compared with abstainers, people with previous‐day pain were more likely to be previous‐day or other users. With regard to the quantity and frequency of alcohol use, people with previous‐day pain were more likely to be non‐heavy drinkers.ConclusionOverall, we found that, in this population of older adults in six LMICs, recent pain was associated with moderate use of alcohol, although there were differences between countries. The findings provide a platform for country‐specific research to better understand bi‐directional associations between pain and alcohol in older adults.
Antagonistic control of flowering time by functionally specialized poly(A) polymerases in Arabidopsis thaliana
Authors: Czesnick Hjördis , Lenhard Michael 
Published: July 2016

SummaryPolyadenylation is a critical 3′‐end processing step during maturation of pre‐mRNAs, and the length of the poly(A) tail affects mRNA stability, nuclear export and translation efficiency. The Arabidopsis thaliana genome encodes three canonical nuclear poly(A) polymerase (PAPS) isoforms fulfilling specialized functions, as reflected by their different mutant phenotypes. While PAPS1 affects several processes, such as the immune response, organ growth and male gametophyte development, the roles of PAPS2 and PAPS4 are largely unknown. Here we demonstrate that PAPS2 and PAPS4 promote flowering in a partially redundant manner. The enzymes act antagonistically to PAPS1, which delays the transition to flowering. The opposite flowering‐time phenotypes in paps1 and paps2 paps4 mutants are at least partly due to decreased or increased FLC activity, respectively. In contrast to paps2 paps4 mutants, plants with increased PAPS4 activity flower earlier than the wild‐type, concomitant with reduced FLC expression. Double mutant analyses suggest that PAPS2 and PAPS4 act independently of the autonomous pathway components FCA, FY and CstF64. The direct polyadenylation targets of the three PAPS isoforms that mediate their effects on flowering time do not include FLC sense mRNA and remain to be identified. Thus, our results uncover a role for canonical PAPS isoforms in flowering‐time control, raising the possibility that modulating the balance of the isoform activities could be used to fine tune the transition to flowering.
Brain train to combat brain drain; focus on exercise strategies that optimize neuroprotection
Authors: Burley Claire V. , Bailey Damian M. , Marley Christopher J. , Lucas Samuel J. E. 
Published: July 2016

New Findings

What is the topic of this review?
The topic of this review is to consider innovative exercise strategies that optimize neuroprotection in order to combat cognitive decline and neurodegenerative disease in older age.

What advances does it highlight?
The review summarizes current understanding around exercise mode, duration, frequency and intensity, and then highlights adaptive roles of select stressors that have equal if not indeed greater capacity than exercise per se to induce health‐related adaptation in the brain. These stressors include, but are not exclusively limited to, hydrostatic and thermal stress, hypoxia, nutritional supplementation and cognitive loading, and are effective by targeting specific pathways that collectively contribute towards improved brain structure and function.

The prevalence of cognitive decline and neurodegenerative diseases (e.g. stroke and dementia) is increasing. Numerous studies show that regular exercise has beneficial effects on brain health in clinical and non‐clinical populations, yet adherence to public health exercise guidelines is notoriously poor. Recently, novel exercise strategies have been investigated to allow for more individualized and prescriptive approaches that target the key mechanistic pathways that allow exercise to mediate adaptation. This work exploring alternative approaches to the traditional model of exercise training has demonstrated exciting potential for positive health‐related adaptations (especially for metabolic, muscle and cardiovascular function). However, few studies to date have focused on brain adaptations. The aim of this review is to summarize new and innovative interventions that have the potential to optimize exercise for improved brain health (i.e. brain structure and function). First, we briefly summarize current understanding of the nature whereby positive effects of exercise deliver their influence on the brain (i.e. underlying mechanisms and factors affecting its delivery). Second, we introduce the effects of exercise training on cognition and give examples of studies showing the beneficial effects of exercise in clinical populations. Finally, we explore the adaptive roles of individual stressors that may induce greater health‐related adaptations in the brain than exercise alone, including environmental stressors (hydrostatic stress, thermal stress and hypoxia), nutritional supplementation and cognitive loading. In summary, optimized interventions that target key mechanistic pathways linked to improved brain structure and function could ultimately protect against and/or ameliorate cognitive decline and neurodegenerative diseases.
Las conferencias episcopales: situación y perspectivas de un debate inconcluso
Authors: Schickendantz Carlos 
Published: July 2016

<p>La construcción de estructuras colegiales y sinodales después del Concilio se ha desarrollado de modo vacilante. El tema refleja discusiones fundamentales y en buena medida permite percibir las orientaciones de fondo en la eclesiología reciente. El artículo muestra los principales momentos en el desarrollo histórico, ensaya una descripción de la nueva situación en que nos encontramos, refiere a los argumentos en juego, individualiza las principales ideas por profundizar y, finalmente, sugiere algunas recomendaciones.</p>
La espiritualidad en Ignacio Ellacuría
Authors: Arango Alzate Oscar , Solano Pinzón Orlando 
Published: July 2016

<p>La espiritualidad no es una realidad estática y ajena a las problemáticas que viven las mujeres y los hombres en su historicidad; por el contrario, emerge en su acontecer histórico como fruto de la docilidad a la acción de Espíritu, que configura un modo particular de existencia. El presente escrito busca dar razón de esta forma histórica y encarnada de entender la espiritualidad, a partir del pensamiento teológico de Ignacio Ellacuría.</p>
El “lugar teológico” en Jon Sobrino
Authors: Costadoat Jorge 
Published: July 2016

<p>Este trabajo indaga en la relevancia del término “lugar teológico” en Jon Sobrino. Partimos de un supuesto fundamental de la teología de la liberación, a saber, que Dios se hace presente y continúa revelándose en la historia actual. Se abordan, en esta tarea, la controversia sobre el método teológico del autor y su recurso al círculo hermenéutico para comprender la revelación a partir de la praxis de seguimiento de Cristo.</p>
Silent God in a Wordy World. Silence in Ignatian Spirituality
Authors: García de Castro Valdés, S.J. José 
Published: July 2016

<p>The Society of Jesus is an apostolic religious order involved in many different activities and missions. Jesuits live far away from monasteries and strict contemplative life. Nevertheless, one of the most well-known peculiarities of the Ignatian Spiritual Exercises is that a complete and absolute silence is required during the time of the retreat. Where and how should we place “silence” in the life of an Ignatian spiritual and mystical experience?</p>
Design and Performance Evaluation of a Heat Exchanger Network for a Cogeneration DMS to Various Thermal Utilization Applications
Authors: Ge Gaoming , Simonson Carey J. 
Published: July 2016

Hitachi-GE developed a 300-MWe-class modular simplified and medium small reactor (DMS) between 2000 and 2004. It was designed to have merits over traditional nuclear power plants in areas of lower initial capital investment, flexibility, enhanced safety, and security. The balance of plant (BOP) system of the DMS was originally designed for supplying just electricity. In this study, the cogeneration DMS that supplies both electricity and heat is under investigation. The heat exchanger (HX) network, mainly consisting of the BOP heat exchanger, water pump, and the heat exchangers that deliver heat to the thermal utilization (TU) applications, must operate in an efficient way to keep the overall system costs low. In this paper, the configuration of a heat exchanger network that serves for various TU applications is investigated first. A numerical model for the heat exchanger network is built, and sensitivity studies are performed to estimate the energy efficiency and exergy efficiency of the whole heat exchanger network under different design and operating conditions (e.g., different water temperatures and flow rates). Important design and operating parameters, which significantly impact the performance of the network, are evaluated and presented.
Genome Sequence of the K139-Like Phage VcP032 Originating from the
Vibrio cholerae
O1 El Tor Ogawa Serotype
Authors: Jäckel Claudia , Strauch Eckhard , Hammerl Jens Andre 
Published: July 2016

ABSTRACT

Vibrio cholerae
is the cause of large cholera outbreaks, especially in endemic regions with high poverty and inadequate sanitation. Here, we announce the complete genome sequence of the virulence-associated broad host range
V. cholerae
phage VcP032, including a brief summary of its genotypic and phenotypic features.
Genome Sequence of
Fusarium
Isolate MYA-4552 from the Midgut of
Anoplophora glabripennis
, an Invasive, Wood-Boring Beetle
Authors: Herr Joshua R. , Scully Erin D. , Geib Scott M. , Hoover Kelli , Carlson John E. , Geiser David M. 
Published: July 2016

ABSTRACT

The
Fusarium solani
species complex (FSSC) is a clade of environmentally ubiquitous fungi that includes plant, animal, and insect associates. Here, we report the draft genome sequence of the undescribed species FSSC 6 (isolate MYA-4552), housed in the gut of the wood-boring cerambycid beetle
Anoplophora glabripennis
.
Complete Genome Sequence of Highly Virulent
Haemophilus parasuis
Serotype 11 Strain SC1401
Authors: Dai Ke , Jin Jin , Wen Yiping , Wen Xintian , He Lvqin , Cao Sanjie , Huang Xiaobo , Wu Rui , Zhao Qin 
Published: July 2016

ABSTRACT

Haemophilus parasuis
, a normal Gram-negative bacterium, may cause Glässer's disease and pneumonia in pigs. This study aims to identify the genes related to natural competence of the serotype 11 strain SC1401, which frequently shows competence and high pathogenicity. SC1401 shows many differences from strains without natural competence within the molecular basis. We performed complete genome sequencing together with restriction modification system analysis to lay the foundation for later study.
Genome Sequence of the Parainfluenza Virus 5 Strain That Persistently Infects AGS Cells
Authors: Wignall-Fleming Elizabeth , Young Dan F. , Goodbourn Steve , Davison Andrew J. , Randall Richard E. 
Published: July 2016

ABSTRACT
We have sequenced the parainfluenza virus 5 strain that persistently infects the commonly used AGS human cell line without causing cytopathology. This virus is most closely related to human strains, indicating that it may have originated from biopsy material or from laboratory contamination during generation of the cell line.
Draft Genome Sequence of
Corynebacterium variabile
Mu292, Isolated from Munster, a French Smear-Ripened Cheese
Authors: Dugat-Bony Eric , Sarthou Anne-Sophie , Loux Valentin , Vidal Marie , Bonnarme Pascal , Irlinger Françoise , Layec Séverine 
Published: July 2016

ABSTRACT

Here, we report the draft genome sequence of
Corynebacterium variabile
Mu292, which was originally isolated from the surface of Munster, a French smear-ripened cheese. This genome investigation will improve our knowledge on the molecular determinants potentially involved in the adaptation of this strain during the Munster-type cheese manufacturing process.
Draft Genome Sequence of
Klebsiella variicola
Strain KV321 Isolated from Rhizosphere Soil of
Pisolithus tinctorius-Eucalyptus
Mycorrhiza
Authors: Jiang Shao-feng , Liu Yi , Xiao Mi-yun , Ruan Chu-jin , Lu Zu-jun 
Published: July 2016

ABSTRACT

The draft genome sequences of
Klebsiella variicola
strain KV321, which was isolated from rhizosphere soil of
Pisolithus tinctorius-Eucalyptus
mycorrhiza, are reported here. The genome sequences contain genes involved in ABC transporter function in multiple-antibiotic drug resistance and colonization. This genomic analysis will help understand the genomic basis of
K. variicola
virulence genes and how the genes play a part in its interaction with other living organisms.
Draft Genome Sequence of a
Dyella
-Like Bacterium from the Planthopper
Hyalesthes obsoletus
Authors: Lahav Tamar , Zchori-Fein Einat , Naor Vered , Freilich Shiri , Iasur-Kruh Lilach 
Published: July 2016

ABSTRACT

We report here the draft genome sequence of a
Dyella
-like bacterium (DLB) isolated from
Hyalesthes obsoletus
, the insect vector of the uncultivable mollicute bacterium “
Candidatus
Phytoplasma.” This isolate inhibits
Spiroplasma melliferum
, a cultivable mollicute. The draft genome of DLB consists of 4,196,214 bp, with a 68.6% G+C content, and 3,757 genes were predicted.
Complete Genome Sequence of Hemolysin-Containing
Carnobacterium
sp. Strain CP1 Isolated from the Antarctic
Authors: Zhu Sidong , Wang Xing , Zhang Di , Jing Xiaohuan , Zhang Ning , Yang Jifang , Chen Jigang 
Published: July 2016

ABSTRACT

Carnobacterium
sp. strain CP1 was isolated from Antarctic sandy soil and predicted to be a novel species belonging to the genus
Carnobacterium
. Herein, we report the complete genome sequence, which consists of a circular 2,605,518-bp chromosome and an 8,883-bp plasmid with G+C contents of 38.13% and 31.63%, respectively.
Complete Genome Sequence Analysis of a Naturally Reassorted Infectious Bursal Disease Virus from India
Authors: Raja P. , Senthilkumar T. M. A. , Parthiban M. , Thangavelu A. , Gowri A. Mangala , Palanisammi A. , Kumanan K. 
Published: July 2016

ABSTRACT
The novel infectious bursal disease virus (IBDV) isolate BGE14/ABT1/MVC/India is a very virulent IBDV that was isolated from broiler flocks in southern parts of India during 2014. Here, we report, for the first time in India, the complete genome sequence of BGE14/ABT1/MVC/India, a reassortment strain with segments A and B derived from a very virulent IBDV strain and an attenuated IBDV, respectively. The findings from this study provide additional insight into the genetic exchange between attenuated and very virulent strains of IBDV circulating in the field.
Draft Genome Sequence of
Chloroflexus
sp. Strain isl-2, a Thermophilic Filamentous Anoxygenic Phototrophic Bacterium Isolated from the Strokkur Geyser, Iceland
Authors: Gaisin Vasil A. , Ivanov Timophey M. , Kuznetsov Boris B. , Gorlenko Vladimir M. , Grouzdev Denis S. 
Published: July 2016

ABSTRACT

We report here the draft genome sequence of the thermophilic filamentous anoxygenic phototrophic bacterium
Chloroflexus
sp. strain isl-2, which was isolated from the Strokkur geyser, Iceland, and contains 5,222,563 bp with a G+C content of 59.65%. The annotated genome sequence offers the genetic basis for understanding the strain's ecological role as a phototrophic bacterium within the bacterial community.
Provision of out-of-hours services for acute upper gastrointestinal bleeding in England: results of the 2014–2015 BSG/NHS England national survey
Authors: Nedjat-Shokouhi Bahman , Glynn Michael , Denton Erika R E , Greenfield Simon M 
Published: July 2016

BackgroundThere has been a drive to raise the standard of management of acute upper gastrointestinal bleeding (AUGIB) in the UK, including three previous audits, sponsored by the British Society of Gastroenterology (BSG).ObjectiveTo review the results of the latest BSG/National Health Service (NHS) England national survey of endoscopy services in England between 2014 and 2015.MethodAll NHS hospitals accepting acute admissions in England (168) were invited to respond to the survey.ResultsOverall, 142 hospitals (84%) returned data. 85% of hospitals used a validated risk assessment score at the time of patient's admission. While 80% of hospitals provided a 24/7 endoscopy service for unstable patients, and another 10% were in network to provide an acute service, only 60% performed an endoscopy within 24 hours for stable acute admissions or inpatients with AUGIB. 11% of hospitals operated an out-of-hours ad hoc rota. 43% felt that pressure from routine work affected their ability to offer a next-day oesophagogastroduodenoscopy service, while 20% of hospitals struggled to recruit endoscopists. 28% of units reported that the previous national audit performed in 2013 had a positive influence on service development.ConclusionsThis survey has revealed significant deficiencies in provision of services for patients with AUGIB in England, without a significant increase in number of hospitals providing an emergency AUGIB service since the last national audit in 2013.
RGS1 expression is associated with poor prognosis in multiple myeloma
Authors: Roh Jin , Shin Su-Jin , Lee A-Neum , Yoon Dok Hyun , Suh Cheolwon , Park Chan-Jeoung , Huh Jooryung , Park Chan-Sik 
Published: July 2016

AimsMultiple myeloma (MM) is an invariably fatal disease with highly heterogeneous outcome. Because of this heterogeneity of MM, risk stratification is crucial for therapeutic decision-making. However, no immunohistochemical prognostic or predictive markers have been established yet. The expression of regulator of G-protein signalling (RGS) proteins, which desensitise G-protein-coupled receptor signalling, has been reported to be associated with the prognosis of various malignancies. Recently, our group demonstrated the importance of RGS1 in chemokine signalling in a human MM cell line and normal plasmablasts. In the present study, we explored the prognostic value of RGS1 expression in patients with MM using immunohistochemistry.MethodsWe evaluated RGS1 protein expression in 79 bone marrow biopsies obtained from patients with MM between 2008 and 2010 at Asan Medical Center. Correlations between RGS1 expression and clinicopathological factors were analysed.ResultsHigh RGS1 protein expression was significantly associated with poor overall survival (p=0.005). After an adjusted multivariable analysis, high RGS1 protein expression (p=0.010), high International Myeloma Working Group risk (p=0.003) and high serum lactate dehydrogenase levels (p=0.040) were significantly associated with poor outcomes.ConclusionsRGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new MM therapy.