bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seasonality and Co‐Detection of Respiratory Viral Infections Among Hospitalised Patients Admitted With Acute Respiratory Illness—Valencia Region, Spain, 2010–2021
Authors: Shirreff George , Chaves Sandra S. , Coudeville Laurent , Mengual‐Chuliá Beatriz , Mira‐Iglesias Ainara , Puig‐Barberà Joan , Orrico‐Sanchez Alejandro , Díez‐Domingo Javier ,   Valencia Hospital Surveillance Network for the Study of Influenza and Other Respiratory Viruses (VAHNSI), Opatowski Lulla , Lopez‐Labrador F. Xavier 
Published: October 2024

ABSTRACTBackgroundRespiratory viruses are known to represent a high burden in winter, yet the seasonality of many viruses remains poorly understood. Better knowledge of co‐circulation and interaction between viruses is critical to prevention and management. We use > 10‐year active surveillance in the Valencia Region to assess seasonality and co‐circulation.MethodsOver 2010–2021, samples from patients hospitalised for acute respiratory illness were analysed using multiplex real‐time PCR to test for 9 viruses: influenza, respiratory syncytial virus (RSV), parainfluenza virus (PIV), rhino/enteroviruses (HRV/ENV), metapneumovirus (MPV), bocavirus, adenovirus, SARS‐CoV‐2 and non‐SARS coronaviruses (HCoV). Winter seasonal patterns of incidence were examined. Instances of co‐detection of multiple viruses in a sample were analysed and compared with expected values under a crude model of independent circulation.ResultsMost viruses exhibited consistent patterns between years. Specifically, RSV and influenza seasons were clearly defined, peaking in December–February, as did HCoV and SARS‐CoV‐2. MPV, PIV and HRV/ENV showed less clear seasonality, with circulation outside the observed period. All viruses circulated in January, suggesting any pair had opportunity for co‐infection. Multiple viruses were found in 4% of patients, with more common co‐detection in children under 5 (9%) than older ages. Influenza co‐detection was generally observed infrequently relative to expectation, while RSV co‐detections were more common, particularly among young children.ConclusionsWe identify characteristic patterns of viruses associated with acute respiratory hospitalisation during winter. Simultaneous circulation permits extensive co‐detection of viruses, particularly in young children. However, virus combinations appear to differ in their rates of co‐detection, meriting further study.
A Strategic Framework of SARS‐CoV‐2 Genomic Surveillance in Bangladesh
Authors: Jubair Mohammad , Hossain Md. Mobarok , Begum Mst. Noorjahan , Moon Shovan Basak , Islam Shahriar , Karim Md. Yeasir , Rahman Sezanur , Khan Manjur H. , Habib Mohammad Tanbir , Shirin Tahmina , Qadri Firdausi , Rahman Mustafizur 
Published: October 2024

ABSTRACTBackgroundThe global pandemic caused by SARS‐CoV‐2 has underlined the significance of strict genomic surveillance to track virus evolution and the possible emergence of new variants, particularly in densely populated countries like Bangladesh. This study outlines a strategic framework of genomic surveillance to track the evolution of the virus in Bangladesh between June 2021 and December 2022 through the National SARS‐CoV‐2 Variant Surveillance (NSVS) program involving collaboration across 4 major institutes and 13 hospitals nationwide.MethodsWe aimed to capture the variants of SARS‐CoV‐2 throughout the country utilizing standardized procedures, modern sequencing technology, and stringent quality control, promoting data accuracy and the timely detection of new variants of concern. We sequenced over 2200 genomes, documenting the prevalence of the Delta variant initially, followed by the emergence of Omicron variants BA.1, BA.2, BA.5, and XBB, each affecting transmission rates and vaccine efficacy differently.ResultsThe clinical manifestations of the variants differed, with some symptoms occurring more frequently in Delta cases and vice versa. Vaccinated individuals were more affected by Omicron cases compared to Delta cases. These variants were responsible for two major COVID‐19 waves in the country, each with significant clinical effects. Phylogenetic analyses placed the local SARS‐CoV‐2 variants within a global context, indicating the Delta variant likely entered from India and Omicron from Europe.ConclusionThis research highlights the significance of collaborative surveillance strategies for guiding public health choices and the critical role of genomic analysis in monitoring virus evolution, shaping targeted pandemic responses. Bangladesh's contributions significantly enhance global insight into COVID‐19's genomic evolution.
International Nurse Migration Experience of the First Two Years: A Mixed Methods Study
Authors: Pressley Charlene , Newton Dillon , Sanderson Linda , Simkhada Bibha , Stephenson John , Duodu Precious Adade , Gillibrand Warren , Pallam Manju , Garside Joanne 
Published: October 2024

ABSTRACTAimThe aim of this study was to explore experiences of internationally educated nurses' first 2 years working and living in England in an age of contemporary migration.DesignExploratory mixed method design.MethodsAn online survey collected responses from August 2022 to October 2022. A mixed‐methods approach was applied to gain a breadth of understanding through quantitative outcomes integrated with depth of qualitative analysis.ResultsData findings from 773 international nurses identified the recognition of prior professional skills and experiences, induction processes, career development systems and the role of line managers are integral to professional integration and could be improved. Communication barriers were frequently transient and time limited, and participants often had incomplete insight of human resource policies. Personal factors affecting life outside of work revealed compromise and sacrifice with accommodation choices, and participants were often not satisfied with their economic status, housing, cost of living in England, and social support. Mental well‐being scores varied by country of origin and participants happier with decision to migrate to England had significantly higher mental well‐being scores.ConclusionInternational nurses have divergent professional and personal motivations for migration unique to individual circumstances. Recognition for transferable skills and experience, receipt of a comprehensive and warm welcome from organisations, safe and well‐maintained suitable accommodation and living conveniently located to shops, work and transportation, improve experience. International nurses must have sufficient financial gains from salaries and opportunity to unite with children and families.Implications for the Profession and/or Patient CareProgressing migration experience of international nurses can improve retention and augment improving patient care and outcomes.Patient or Public ContributionNo patient or members of public contributed to this research.
The Association between Emotional Responses to Climate Change, Antenatal Anxiety and Maternal–Fetal Attachment in Primigravida Women
Authors: Amin Shaimaa Mohamed , El‐Monshed Ahmed Hashem , Khedr Mahmoud Abdelwahab , Awad Amal Gamal Elsayed , Atta Mohamed Hussein Ramadan 
Published: October 2024

ABSTRACTAimTo investigate the association between emotional responses to climate change, antenatal anxiety, and maternal–fetal attachment in primigravida women.DesignA multi‐site cross‐sectional research design study.MethodsThis study was conducted at four primary health care (PHC) facilities in Damanhur district, El‐Behera, from February 2024 to April 2024. Two hundred eighty‐five women completed a comprehensive questionnaire that included a Woman's Social and Reproductive Form, The inventory of climate emotions (ICE) scale, The Stirling Antenatal Anxiety Scale (SAAS) and the Maternal–Fetal Attachment Scale (MFAS‐HU‐20).ResultsThe study revealed that emotional responses to climate change show strong positive correlations with each other, ranging from 0.689 to 0.840, all significant at p < 0.001 level. Additionally, antenatal anxiety demonstrates substantial positive correlations with emotional responses to climate change, albeit with associations ranging from 0.239 to 0.287, all significant at p < 0.001 level. Moreover, maternal–fetal attachment displays substantial negative correlations with emotional responses to climate change, indicating that as emotional responses to climate change increase, maternal–fetal attachment tends to decrease. The correlations range from −0.263 to −0.426, all significant at p < 0.001.ConclusionsThe emotional impact of climate change can adversely affect the bonding process between mother and fetus.Implications for the ProfessionHealthcare professionals, including obstetricians, midwives, and mental health counsellors, should integrate climate‐related emotional distress into their assessments and interventions. Providing targeted psychological support for expectant mothers.ImpactThe study's findings highlight the need for nursing to integrate climate‐related emotional distress screening into prenatal care and for research to explore long‐term effects and intervention effectiveness. In practice, healthcare providers should adopt holistic approaches that combine environmental and psychological support, developing comprehensive guidelines and community‐based programs to support pregnant women.Reporting MethodThe research adhered to that is STROBE.Patient or Public ContributionPublic contributions by women in community health centers.
Identifying Trends in the Most Cited Nursing Articles: Research Topics, Author Gender Representation and Characteristics Correlated With Citation Counts
Authors: Holmberg Christopher 
Published: October 2024

ABSTRACTAimTo assess the top 1000 cited nursing articles in terms of their impact, conceptual and social characteristics.DesignBibliometric literature review design.MethodsA bibliometric analysis on the 1000 most cited nursing articles in English, focusing on assessing their impact and prevalent terms, keywords, co‐occurrence networks and topic trends. Non‐parametric statistical tests were used.Data SourcesWeb of Science Core Collection (accessed 14 February 2024).ResultsThe 1000 most cited articles were exported from 201,310 eligible articles.The most cited articles received a total of 319,643 citations. The Journal of Advanced Nursing and the International Journal of Nursing Studies were the most cited journals. Literature reviews accounted for 21% of the most cited articles, compared to only 7% of all eligible articles. Most first authors were female, 63%. The data showed an increase in female first authorship among the most cited articles over time. This may reflect a shift towards greater gender equity in nursing research. Shorter article titles and fewer article pages were associated with more citations.ConclusionMethodological and conceptual articles received the most citations, likely due to their broad applicability (e.g., across disciplines) and enduring relevance. There was a statistically significant correlation between article brevity and citation count, but the relationship should be viewed with caution given the small effect size.Implications for the ProfessionBibliometrics is important for evidence‐based practice because it helps nurses evaluate journals, articles and research topics. Since citation counts do not always indicate research quality, nurses and nursing students would benefit from training in bibliometrics to enhance their critical thinking in this area.ImpactTop‐cited nursing articles indicate influential research topics and methods. They also influence authors' academic career opportunities, allowing assessment of research equity in terms of dominant countries and author gender representation.Reporting MethodThe Preferred Reporting Items for Bibliometric Analysis (PRIBA) guidelines.Patient or Public ContributionNo Patient or Public Contribution.
Understanding Family Resilience in Young‐Onset Dementia: A Multiple Case Study
Authors: Yang Yoosun , Song Jun‐Ah 
Published: October 2024

ABSTRACTAimThrough the lens of family resilience, exploring the experiences of families in adapting to young‐onset dementia.DesignQualitative multiple case study.MethodsThis study examined the family as a single unit of analysis, focusing on a triad including a person with young‐onset dementia, their spouse and their adult child. Three family triads were included. Data collection took place between April 20 and July 4, 2023, in South Korea. Data analysis involved a two‐stage process, consisting of a directed content analysis based on the family resilience framework within cases, followed by a cross‐case analysis to identify themes and unique patterns across cases.ResultsThe study identified six key themes: (1) Stressors due to a young‐onset dementia diagnosis, (2) perception of the young‐onset dementia diagnosis, (3) degree of emotional connection, (4) coping approach to young‐onset dementia, (5) availability and utilisation of external resources and (6) patterns of adaptation. Furthermore, our research uncovered the interplay between themes, and how adaptations patterns of families formed either resilient or non‐resilient.ConclusionOur triadic approach uncovered hidden family dynamics, emphasising family‐centred care. This study provides insights into unique challenges and diverse adaptation processes, suggesting tailored interventions.Implications for the Profession and/or Patient CareThis study emphasises the importance of family‐centred care in young‐onset dementia, recognising all family members as crucial clients. Also, we suggest that healthcare professionals should develop tailored treatment plans that reflect the unique needs of each family.ImpactThis study presents the unique experiences of young‐onset dementia families, laying the foundation for developing effective support strategies that reflect these insights. Additionally, we emphasise the utilisation of external resources and their existence, providing a comprehensive research direction.Reporting MethodOur research follows the EQUATOR guidelines, specifically adhering to the COREQ guidelines.Patient or Public ContributionNo Patient or Public Contribution.
The roles of G protein‐coupled receptor kinase 2 in renal diseases
Authors: Du Jiayin , Wu Xiaoyan , Ni Lihua 
Published: October 2024

AbstractG protein‐coupled receptor (GPCR) kinase 2 (GRK2) is an integrative node in many signalling network cascades. An emerging study indicates that GRK2 can interact with GPCRs and non‐GPCR substrates in both kinase‐dependent and ‐independent modes. Alterations in the functional levels of GRK2 have been found in a variety of renal diseases, such as hypertension‐related kidney injury, sepsis‐associated acute kidney injury (S‐AKI), cardiorenal syndrome (CRS), acute kidney injury (AKI), age‐related kidney injury or hyperglycemia‐related kidney injury. Abnormal GRK2 expression contribute to the development of renal diseases, making them promising molecular targets for treating renal diseases. Blocking the prostaglandin E2 (PGE2)‐EP1‐Gaq‐Ca2+ signal pathway in glomerular mesangial cells (GMCs) by internalizing prostaglandin E2 receptor 1 (EP1) with GRK2 may be a potential treatment for diabetic nephropathy (DN). In addition, GRK2 inhibition may have therapeutic effects in a variety of renal diseases, such as SLE‐related kidney injury, DN, age‐related kidney injury, hypertension‐related kidney injury, and CRS. However, there is still a long way to go for the large‐scale application of GRK2 inhibition in the field of renal diseases. In this review, we discuss recent updates in understanding the role of GRK2 in kidney dysfunction. Furthermore, we explore the potential of GRK2 as a possible therapeutic target for renal pathologies. We believe it will shed light on the future development of small‐molecule inhibitors of GRK, as well as the clinical applications in renal diseases.
Evolution of the Guided Direct Composite Resin Technique in Restorative Dentistry: A Systematic Review
Authors: Tolotti Taina , Sesma Newton , Mukai Eduardo 
Published: October 2024

ABSTRACTObjectiveThis systematic review aims to understand the limitations and benefits of the guided direct restorative technique, to optimize the final outcomes, considering the evolution from analog to digital, including planning, the diversification of guides, and the different resins employed.MethodologyA search was conducted in the electronic databases PubMed, Cochrane, and through manual searches, initiated in May 2023 and updated in April 2024. The following search strategy was used: ((injectable composite resin) OR (direct pressed composite)) OR (3D‐guided), utilizing the PICO framework.ResultsInitially, 739 articles were retrieved. After applying inclusion and exclusion criteria, 33 studies were considered suitable for data extraction, including 12 in vitro studies and 21 case reports or technique descriptions. The articles focused on comparisons of techniques, flowable, heated, and conventional resins, as well as various technique reports with variations in guides, materials, and planning, potentially aiding clinicians in more effective and safer execution of this restorative technique.ConclusionThe utilization of digital workflows presents greater solutions to the challenges of the guided direct restorative technique. Understanding the properties of the resins used is crucial for the results and should be chosen according to the patient's needs.Clinical SignificanceA guided direct restorative procedure can deliver previously planned dental treatment based on individualized planning. This method ensures greater reproducibility in aesthetics and occlusion, resulting in superior quality work for the patient.
Tariffs and Foreign Direct Investment in a Dynamic North–South Model
Authors: IWAISAKO TATSURO , TANAKA HITOSHI 
Published: October 2024

AbstractThis paper examines how import tariffs by a developed country (the North) and a developing country (the South) affect innovation and foreign direct investment (FDI) using a quality ladder model. We show that a Northern import tariff raises the relative wage of Northern labor, but impedes innovation and FDI. This may worsen Northern welfare. By contrast, a Southern import tariff raises the relative wage of Southern labor and promotes innovation and FDI. This can improve Southern welfare. These imply that the South has a stronger incentive than the North to impose an import tariff, which is consistent with actual observation.
Lack of association between the length of anogenital distance and vaginal pH in women with endometriosis
Authors: Khan Khaleque N. , Fujishita Akira , Hiraki Koichi , Ogawa Kanae , Horiguchi Go , Teramukai Satoshi , Fujieda Mikiya , Mori Taisuke 
Published: October 2024

AbstractAimWe investigated the association between the length of anogenital distance (AGD) and intra‐vaginal pH, an indicator of vaginal eubiosis or dysbiosis, in women with endometriosis.MethodsA prospective cohort study was performed including patients with (n = 67) and without (n = 40) endometriosis undergoing surgery between July 2021 and June 2022. AGD was measured from the posterior fourchette to the center of the anus using digital caliper and vaginal pH was measured by inserting pH paper strip mostly into the posterior fornix.ResultsThere was no significant difference in the median AGD among control women (n = 40) (21.5 mm), women with revised‐American Society of Reproductive Medicine stage I–II endometriosis (n = 27) (22.0 mm) and stage III–IV endometriosis (n = 40) (20.0 mm). In contrast, a significant difference of vaginal pH was observed among groups (p = 0.012) and between groups: control versus stage I–II, p = 0.004; stage I–II, versus stage III–IV, p = 0.037. After adjusting different confounding variables, the univariate analysis showed that women with endometriosis are less likely to have an alkaline vaginal pH (≥4.5) (OR [95% CI] = 0.40 [0.17, 0.93], p = 0.034). Multivariate analysis revealed that AGD or any of the other variables did not serve as an independent risk factor to predict the presence of endometriosis.ConclusionsThis study with Japanese women suggests a lack of association between length of AGD, either shorter or longer, and the status of vaginal pH or the presence of endometriosis in pelvis.
The effect of concurrent clopidogrel and omeprazole administration on clopidogrel metabolism and platelet function in healthy cats
Authors: Plante Christina , Lee Pamela M. , Haines Jillian M. , Nelson O. Lynne , Martinez Stephanie E. , Court Michael H. 
Published: October 2024

AbstractBackgroundSome studies in humans show that the concurrent use of clopidogrel and omeprazole decreases plasma clopidogrel active metabolite (CAM) concentrations and clopidogrel antiplatelet effects. Whether this drug interaction occurs in cats is unknown.HypothesisWe hypothesized that administration of clopidogrel with omeprazole would decrease plasma CAM concentrations and decrease clopidogrel antiplatelet effects in healthy cats.AnimalsTen domestic cats.MethodsIn this 2‐sequence, 2‐period, 2‐treatment randomized crossover study, healthy cats were randomly assigned to receive clopidogrel only (18.75 mg PO q24h) or clopidogrel with omeprazole (1 mg/kg PO q12h) for 10 days, followed by a 2‐week washout period, and then the opposite treatment for another 10 days. Blood was collected by jugular venipuncture on days 0, 5, and 10. Plasma CAM concentrations were measured using high‐performance liquid chromatography‐tandem mass spectrometry. Platelet function was evaluated using Plateletworks, Multiplate Analyzer, and Platelet Function Analyzer‐100 (PFA‐100).ResultsMultiplate Analyzer and PFA‐100 detected no difference in platelet function between days or treatment groups. Plateletworks detected a significant difference (P < .001) in platelet function from day 0 to 5 and day 0 to 10 in both treatment groups but no difference between treatment groups. Plasma CAM concentrations were significantly lower on day 10 (P < .02) in cats receiving both medications versus clopidogrel only.Conclusions and Clinical ImportanceConcurrent omeprazole and clopidogrel administration was associated with altered pharmacokinetics on day 10, but no difference in pharmacodynamics between the 2 treatment groups. The short‐term use of clopidogrel and omeprazole does not seem to alter platelet function significantly.
Repeated shifts out of tropical climates preceded by whole genome duplication
Authors: Carruthers Tom , Gonçalves Deise J. P. , Li Pan , Chanderbali Andre S. , Dick Christopher W. , Fritsch Peter W. , Larson Drew A. , Soltis Douglas E. , Soltis Pamela S. , Weaver William N. , Smith Stephen A. 
Published: October 2024

Summary
While flowering plants have diversified in virtually every terrestrial clime, climate constrains the distribution of individual lineages. Overcoming climatic constraints may be associated with diverse evolutionary phenomena including whole genome duplication (WGD), gene‐tree conflict, and life‐history changes. Climatic shifts may also have facilitated increases in flowering plant diversification rates. We investigate climatic shifts in the flowering plant order Ericales, which consists of c. 14 000 species with diverse climatic tolerances.
We estimate phylogenetic trees from transcriptomic data, 64 chloroplast loci, and Angiosperms353 nuclear loci that, respectively, incorporate 147, 4508, and 2870 Ericales species. We use these phylogenetic trees to analyse how climatic shifts are associated with WGD, gene‐tree conflict, life‐history, and diversification rates.
Early branches in the phylogenetic trees are extremely short, and have high levels of gene‐tree conflict and at least one WGD. On lineages descended from these early branches, there is a significant association between climatic shifts (primarily out of tropical climates), further WGDs, and life‐history.
Extremely short early branches, and their associated gene‐tree conflict and WGDs, appear to underpin the explosive origin of numerous species rich Ericales clades. The evolution of diverse climatic tolerances in these species rich clades is tightly associated with WGD and life‐history.