bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential expression of alarmins—S100A9, IL-33, HMGB1 and HIF-1α in supraspinatus tendinopathy before and after treatment
Authors: Mosca Michael J , Carr Andrew J , Snelling Sarah J B , Wheway Kim , Watkins Bridget , Dakin Stephanie G 
Published: June 2017

BackgroundAlarmins, endogenous molecules released on tissue damage have been shown to play an important role in inflammatory musculoskeletal conditions including fracture repair andrheumatoid arthritis. However, the contribution of alarmins to the pathogenesis of tendon disease is not fully understood.MethodsWe investigated expression of alarmin proteins (S100A9, high-mobility group box 1 (HMGB1) and interleukin-33 (IL-33) and hypoxia-inducible factor 1α (HIF-1α), a subunit of an oxygen sensitive transcription factor, in three cohorts of human supraspinatus tissues: healthy (n=6), painful diseased (n=13) and post-treatment pain-free tendon samples (n=5). Tissue samples were collected during shoulder stabilisation surgery (healthy) or by biopsy needle (diseased/treated). Immunohistochemistry was used to investigate the protein expression of these factors in these healthy, diseased and treated tendons. Kruskal-Wallis with pairwise post hoc Mann-Whitney U tests were used to test for differences in immunopositive staining between these tissue cohorts. Additionally, costaining was performed to identify the cell types expressing HIF-1α, S100A9, IL-33 and HMGB1 in diseased tendons.ResultsImmunostaining showed HIF-1α and S100A9 were increased in diseased compared with healthy and post-treatment pain-free tendons (p<0.05). IL-33 was reduced in diseased compared with healthy tendons (p=0.0006). HMGB1 was increased in post-treatment pain-free compared with healthy and diseased tendons (p<0.01). Costaining of diseased tendon samples revealed that HIF-1α, S100A9 and IL-33 were expressed by CD68+ and CD68− cells, whereas HMGB1 was predominantly expressed by CD68− cells.ConclusionsThis study provides insight into the pathways contributing to the progressionand resolution of tendon disease. We found potential pro-inflammatory and pathogenic roles for HIF-1α and S100A9, a protective role fornuclear IL-33 and a potentially reparative function for HMGB1 in diseased supraspinatus tendons.
Green synthesis and characterization of ANbO3 (A = Na, K) nanopowders fabricated using a biopolymer
Authors: Khorrami Gh. H. , Mousavi M. , Khayatian S. A. , Kompany A. , Khorsand Zak A. 
Published: June 2017

Lead-free sodium niobate (NaNbO3, NN) and potassium niobate (KNbO3, KN) nanopowders were successfully synthesized by a simple and green synthesis process in gelatin media. Gelatin, which is a biopolymer, was used as stabilizer. In order to determine the lowest calcination temperature needed to obtain pure NN and KN nanopowders, the produced gels were analyzed by thermogravometric analyzer (TGA). The produced gels were calcined at 500[Formula: see text]C and 600[Formula: see text]C. The structural and optical properties of the prepared powders were examined using X-ray diffraction (XRD) technique, transmission electron microscopy (TEM), and UV–Vis spectroscopy. The XRD results revealed that pure phase NN and KN nanopowders were formed at low temperature calcination of 500[Formula: see text]C and 600[Formula: see text]C, respectively. The Scherrer formula and size-strain plot (SSP) method were employed to estimate crystallite size and lattice strain of the samples. The TEM images show that the NN and KN samples calcined at 600[Formula: see text]C have cubic shape with an average particle size of 60.95 and 39.29 nm, respectively. The optical bandgap energy of the samples was calculated using UV–Vis diffused reflectance spectra of the samples and Kubelka–Munck relation.
EET intervention on Wnt1, NOV, and HO-1 signaling prevents obesity-induced cardiomyopathy in obese mice
Authors: Cao Jian , Singh Shailendra P. , McClung John A. , Joseph Gregory , Vanella Luca , Barbagallo Ignazio , Jiang Houli , Falck John R. , Arad Michael , Shapiro Joseph I. , Abraham Nader G. 
Published: June 2017

We have previously reported that epoxyeicosatrienoic acid (EET) has multiple beneficial effects on vascular function; in addition to its antiapoptotic action, it increases insulin sensitivity and inhibits inflammation. To uncover the signaling mechanisms by which EET reduces cardiomyopathy, we hypothesized that EET infusion might ameliorate obesity-induced cardiomyopathy by improving heme oxygenase (HO)-1, Wnt1, thermogenic gene levels, and mitochondrial integrity in cardiac tissues and improved pericardial fat phenotype. EET reduced levels of fasting blood glucose and proinflammatory adipokines, including nephroblastoma overexpressed (NOV) signaling, while increasing echocardiographic fractional shortening and O2 consumption. Of interest, we also noted a marked improvement in mitochondrial integrity, thermogenic genes, and Wnt 1 and HO-1 signaling mechanisms. Knockout of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in EET-treated mice resulted in a reversal of these beneficial effects including a decrease in myocardial Wnt1 and HO-1 expression and an increase in NOV. To further elucidate the effects of EET on pericardial adipose tissues, we observed EET treatment increases in adiponectin, PGC-1α, phospho-AMP-activated protein kinase, insulin receptor phosphorylation, and thermogenic genes, resulting in a “browning” pericardial adipose phenotype under high-fat diets. Collectively, these experiments demonstrate that an EET agonist increased Wnt1 and HO-1 signaling while decreasing NOV pathways and the progression of cardiomyopathy. Furthermore, this report presents a portal into potential therapeutic approaches for the treatment of heart failure and metabolic syndrome. NEW & NOTEWORTHY The mechanism by which EET acts on obesity-induced cardiomyopathy is unknown. Here, we describe a previously unrecognized function of EET infusion that inhibits nephroblastoma overexpressed (NOV) levels and activates Wnt1, hence identifying NOV inhibition and enhanced Wnt1 expression as novel pharmacological targets for the prevention and treatment of cardiomyopathy and heart failure. Listen to this article's corresponding podcast at http://ajpheart.physiology.org/content/early/2017/05/31/ajpheart.00093.2017 .
Effect of calf-raise training on rapid force production and balance ability in elderly men
Authors: Ema Ryoichi , Ohki Shunsuke , Takayama Hirokazu , Kobayashi Yuji , Akagi Ryota 
Published: June 2017

This study examined whether home-based, high-speed calf-raise training changes the rate of torque development (RTD) during plantar flexion contractions and balance performance in elderly men. Thirty-four healthy elderly men (73 ± 5 yr) were randomly assigned to a training or control group ( n = 17 in each group). The subjects in the training group completed 8 wk (3 times/wk) of home-based bilateral calf-raise training using body mass. Before and after the intervention, RTD during plantar flexion contractions and center-of-pressure (COP) displacement during single-leg standing were measured. Surface electromyographic amplitude of the triceps surae and tibialis anterior during the strength and single-leg standing was measured. Clinical magnitude-based inferences were used to interpret the training effect, with the smallest worthwhile effect assumed to be 0.2 of the baseline SD. The peak RTD increased 21% (90% confidence limits, ±19%) relative to the control group, which was accompanied by corresponding changes of the medial gastrocnemius (MG) and soleus (SOL) activations. The effect on COP displacement was possibly trivial (0%, ±13%), whereas substantial reduction in the MG (−19%, ±15%) and SOL (−25%, ±13%) activations during standing was observed. Our findings indicate that calf-raise training at home, performed without special equipment or venue, induces a substantial increase in the plantar flexors’ rapid force-generating capability and triceps surae activations. Although the training effect on standing balance performance was not substantial, observed changes in the triceps surae activations during standing are expected to contribute to future balance performance improvement. NEW & NOTEWORTHY Calf-raise training with the intent to move rapidly, without special equipment or venue, induces an improvement of explosive plantar flexion force, which is attributable to neuromuscular rather than musculotendinous adaptations. Although the training effect on balance performance was trivial, we found a sign of improvement (i.e., neuromuscular adaptations during standing). In conclusion, functional neuromuscular capacity can be enhanced by home-based calf-raise exercise in elderly men, which may protect against mobility loss with aging.
Quantifying the Benefits of Genome-Driven Oncology
Authors: Schram Alison M. , Hyman David M. 
Published: June 2017

Abstract
Summary: The excitement surrounding genomically selected cancer therapy has led many to question whether this treatment paradigm is living up to its initial promise. The MOSCATO study suggests that a genome-driven strategy for cancer therapy improves outcomes in a significant minority of patients who undergo molecular screening. Cancer Discov; 7(6); 552–4. ©2017 AACR.
See related article by Massard et al., p. 586.
Novel “Elements” of Immune Suppression within the Tumor Microenvironment
Authors: Gurusamy Devikala , Clever David , Eil Robert , Restifo Nicholas P. 
Published: June 2017

AbstractAdaptive evolution has prompted immune cells to use a wide variety of inhibitory signals, many of which are usurped by tumor cells to evade immune surveillance. Although tumor immunologists often focus on genes and proteins as mediators of immune function, here we highlight two elements from the periodic table—oxygen and potassium—that suppress the immune system in previously unappreciated ways. While both are key to the maintenance of T-cell function and tissue homeostasis, they are exploited by tumors to suppress immuno-surveillance and promote metastatic spread. We discuss the temporal and spatial roles of these elements within the tumor microenvironment and explore possible therapeutic interventions for effective and promising anticancer therapies. Cancer Immunol Res; 5(6); 426–33. ©2017 AACR.
Efeito da prática de instrumentos musicais nas disfunções temporomandibulares e distúrbios do sono
Authors: Mariotto Lígia Gabrielle Sanches , Caetano Kátia Alessandra de Souza , Vidal Carla Larissa , Reis Andréa Cândido dos 
Published: June 2017

The aim of this study was to evaluate the relation among recreational practice of musical instruments, temporomandibular disorders (TMDs), and sleep disturbances in a sample of musicians that are members of orchestras in a southeast area of Brazil. The participants practice playing instruments as a leisure activity. Method: this was a cross-sectional study with two groups. The comparison group included members from the general population. Both group included 43 adults, being 14 women and 29 men. The mean age of comparison group is 28.35 (±4.867), and the mean age of musician group is 28.37 (±6.712). The participants completed self-rated questionnaires to assess TMDs symptoms and sleep disturbance. Results: tThe groups did not differ regarding the presence of TMDs symptoms, sleep disturbance, and demographic variables. A strong and negative correlation was observed between TMDs and time of playing a musical instrument. The participants with less practice in years in playing a musical instrument have 8.57 more chance of having TMDs than the musicians with a long history of playing an instrument. Conclusion: it seems that a long history of practicing a musical instrument as a leisure activity is associated with a lower chance of developing TMDs. This study reinforces the benefits of playing a musical instrument as a leisure activity to physical health, specifically, as a protective factor to developing TMDs.
Color stability evaluation of micro hybrid composite resins submitted to accelerated artificial aging
Authors: Ávila Gisseli Bertozzi , Dias Sérgio Candido , Valente Mariana Lima da Costa , Agnelli José Augusto Marcondes , Reis Andréa Cândido dos 
Published: June 2017

Objective: The aesthetics of dental materials is extremely important for the success of oral rehabilitation. Thus, in the present study we evaluated the color stability and the surface degradation of three micro hybrid composite resins after accelerated artificial aging process (AAA). Methods: Were prepared 24 specimens (n=8) for each material: Solidex, Artglass and Cesead, dimensions of Ø 15 mm by 2 mm in thickness. The samples were subjected to color analysis, before and after AAA, in a spectrophotometer according to the CIE L*a*b* parameters, and a sample of each material, was selected for morphological evaluation under scanning electron microscopy (SEM). The data were submitted to one-way ANOVA and Tukey test (α=0.05). Results: Artglass showed higher stability regarding the presence of red and yellow (p<0.05) when subjected to the AAA and fewer of these pigments (p<0.05) when compared to the Cesead and Solidex, which showed the highest luminance stability (p<0.05). ΔE Cesead was the most unstable (p<0.05). All resins analyzed by SEM showed superficial degradation when submitted to the AAA, mainly in resin Cesead. Conclusion: All materials analyzed demonstrate color change and surface degradation, Cesead resin showed the worse results.
Impact of Preeclampsia on Clinical and Functional Outcomes in Women With Peripartum Cardiomyopathy
Authors: Lindley Kathryn J. , Conner Shayna N. , Cahill Alison G. , Novak Eric , Mann Douglas L. 
Published: June 2017

Background—
Preeclampsia is a risk factor for the development of peripartum cardiomyopathy (PPCM), but it is unknown whether preeclampsia impacts clinical or left ventricular (LV) functional outcomes. This study sought to assess clinical and functional outcomes in women with PPCM complicated by preeclampsia.

Methods and Results—

This retrospective cohort study included women diagnosed with PPCM delivering at Barnes-Jewish Hospital between 2004 to 2014. The primary outcome was one-year event-free survival rate for the combined end point of death and hospital readmission. The secondary outcome was recovery of LV ejection fraction. Seventeen of 39 women (44%) with PPCM had preeclampsia. The groups had similar mean LV ejection fraction at diagnosis (29.6 with versus 27.3 without preeclampsia;
P
=0.5). Women with preeclampsia had smaller mean LV end-diastolic diameters (5.2 versus 6.0 cm;
P
=0.001), greater relative wall thickness (0.41 versus 0.35 mm Hg;
P
=0.009), and lower incidence of eccentric remodeling (12% versus 48%;
P
=0.03). Clinical follow-up was available for 32 women; 5 died of cardiovascular complications within 1 year of diagnosis (4/15 with versus 1/17 without preeclampsia;
P
=0.16). In time to event analysis, patients with preeclampsia had worse event-free survival during 1-year follow-up (
P
=0.047). Echocardiographic follow-up was available in 10 survivors with and 16 without preeclampsia. LV ejection fraction recovered in 80% of survivors with versus 25% without preeclampsia (
P
=0.014).

Conclusions—
PPCM with concomitant preeclampsia is associated with increased morbidity and mortality and different patterns of LV remodeling and recovery of LV function when compared with patients with PPCM that is not complicated by preeclampsia.
Impact of Mean Transaortic Pressure Gradient on Long‐Term Outcome in Patients With Severe Aortic Stenosis and Preserved Left Ventricular Ejection Fraction
Authors: Bohbot Yohann , Kowalski Cedric , Rusinaru Dan , Ringle Anne , Marechaux Sylvestre , Tribouilloy Christophe 
Published: June 2017

Background

Mean transaortic pressure gradient (
MTPG
) has never been validated as a predictor of mortality in patients with severe aortic stenosis. We sought to determine the value of
MTPG
to predict mortality in a large prospective cohort of severe aortic stenosis patients with preserved left ventricular ejection fraction and to investigate the cutoff of 60 mm Hg, proposed in American guidelines.

Methods and Results

A total of 1143 patients with severe aortic stenosis defined by aortic valve area ≤1 cm
2
and
MTPG
≥40 mm Hg were included. The population was divided into 3 groups according to
MTPG
: between 40 and 49 mm Hg, between 50 and 59 mm Hg, and ≥60 mm Hg. The end point was all‐cause mortality.
MTPG
was ≥60 mm Hg in 392 patients. Patients with
MTPG
≥60 mm Hg had a significantly increase risk of mortality compared with patients with
MTPG
<60 mm Hg (hazard ratio [
HR
]=1.62 [1.27–2.05]
P
<0.001), even for the subgroup of asymptomatic or minimally symptomatic patients (
HR
=1.56 [1.04–2.34]
P
=0.032). After adjustment for established outcome predictors, patients with
MTPG
≥60 mm Hg had a significantly higher risk of mortality than patients with
MTPG
<60 mm Hg (
HR
=1.71 [1.33–2.20]
P
<0.001), even after adjusting for surgery as a time‐dependent variable (
HR
=1.71 [1.43–2.11]
P
<0.001). Similar results were observed for the subgroup of asymptomatic or minimally symptomatic patients (
HR
=1.70 [1.10–2.32]
P
=0.018 and
HR
=1.68 [1.20–2.36]
P
=0.003, respectively).

Conclusions

This study shows the negative prognostic impact of high
MTPG
(≥60 mm Hg), on long‐term outcome of patients with severe aortic stenosis with preserved left ventricular ejection fraction, irrespective of symptoms.
Accessible Environments for Diurnal-Period Waves in Simulated Tropical Cyclones
Authors: O’Neill Morgan E , Perez-Betancourt Diamilet , Wing Allison A. 
Published: June 2017

Abstract
A recent observational analysis has reported significant repeating diurnal signals propagating outward at cloud-top height from tropical cyclone centers. Modeling studies suggest that the visible upper-level impacts reflect a diurnal cycle through the depth of the troposphere. In this study, the possibility of wavelike diurnal responses in tropical cyclones is characterized using 3D cloud-resolving numerical simulations with and without a diurnal cycle. Diurnal waves can only begin to propagate well beyond the storm core, and the outflow region is most receptive to near-core diurnal propagation because of its anticyclonic flow. The tropical cyclone structure appears particularly hostile to diurnal wave propagation during periods when the eyewall experiences a temporary breakdown similar to an eyewall replacement cycle.
Impact of Poleward Moisture Transport from the North Pacific on the Acceleration of Sea Ice Loss in the Arctic since 2002
Authors: Lee H. J. , Kwon M. O. , Yeh S.-W. , Kwon Y.-O. , Park W. , Park J.-H. , Kim Y. H. , Alexander M. A. 
Published: June 2017

Abstract
Arctic sea ice area (SIA) during late summer and early fall decreased substantially over the last four decades, and its decline accelerated beginning in the early 2000s. Statistical analyses of observations show that enhanced poleward moisture transport from the North Pacific to the Arctic Ocean contributed to the accelerated SIA decrease during the most recent period. As a consequence, specific humidity in the Arctic Pacific sector significantly increased along with an increase of downward longwave radiation beginning in 2002, which led to a significant acceleration in the decline of SIA in the Arctic Pacific sector. The resulting sea ice loss led to increased evaporation in the Arctic Ocean, resulting in a further increase of the specific humidity in mid-to-late fall, thus acting as a positive feedback to the sea ice loss. The overall set of processes is also found in a long control simulation of a coupled climate model.
Quantifying Spatiotemporal Variations of Soil Moisture Control on Surface Energy Balance and Near-Surface Air Temperature
Authors: Schwingshackl Clemens , Hirschi Martin , Seneviratne Sonia I. 
Published: June 2017

Abstract
Soil moisture plays a crucial role for the energy partitioning at Earth’s surface. Changing fractions of latent and sensible heat fluxes caused by soil moisture variations can affect both near-surface air temperature and precipitation. In this study, a simple framework for the dependence of evaporative fraction (the ratio of latent heat flux over net radiation) on soil moisture is used to analyze spatial and temporal variations of land–atmosphere coupling and its effect on near-surface air temperature. Using three different data sources (two reanalysis datasets and one combination of different datasets), three key parameters for the relation between soil moisture and evaporative fraction are estimated: 1) the frequency of occurrence of different soil moisture regimes, 2) the sensitivity of evaporative fraction to soil moisture in the transitional soil moisture regime, and 3) the critical soil moisture value that separates soil moisture- and energy-limited evapotranspiration regimes. The results show that about 30%–60% (depending on the dataset) of the global land area is in the transitional regime during at least half of the year. Based on the identification of transitional regimes, the effect of changes in soil moisture on near-surface air temperature is analyzed. Typical soil moisture variations (standard deviation) can impact air temperature by up to 1.1–1.3 K, while changing soil moisture over its full range in the transitional regime can alter air temperature by up to 6–7 K. The results emphasize the role of soil moisture for atmosphere and climate and constitute a useful benchmark for the evaluation of the respective relationships in Earth system models.
Incorporating Interpersonal Psychotherapy for Postpartum Depression Into Social Work Practice in Israel
Authors: Posmontier Bobbie , Bina Rena , Glasser Saralee , Cinamon Tali , Styr Benedict , Sammarco Therese 
Published: June 2017

Purpose: To determine feasibility and acceptability of incorporating IPT for postpartum depression (PPD) into Israeli social work practice. Method: Women who were 4–24 weeks postpartum with PPD, at least 18 years old, had telephone access, and had a score of 10–18 on the Edinburgh Postnatal Depression Scale (EPDS) were eligible to participate in this two-group, nonrandomized repeated measures pilot. The intervention group received eight 50-min IPT sessions and the comparison group received treatment-as-usual. Primary outcomes were measured with the EPDS, Postpartum Adjustment Questionnaire (PPAQ), and Client Satisfaction Scale-8. Results: There was a significant reduction in both groups in EPDS scores at the end of treatment ( t = −4.68, 95% CI [−6.49, −2.57], d = 1.07) and 4 weeks posttreatment ( t = −5.09, 95% CI [−7.14, −3.08], p < .001, d = 1.21), a significant reduction in PPAQ scores at the end of treatment ( t = −2.09, 95% CI [−0.29, 0.00], p < .05, d = 0.44), and high patient acceptability. Discussion: This study provided preliminary evidence supporting IPT use by social workers in Israel.
Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2
Authors: Jäckel Sven , Kiouptsi Klytaimnistra , Lillich Maren , Hendrikx Tim , Khandagale Avinash , Kollar Bettina , Hörmann Nives , Reiss Cora , Subramaniam Saravanan , Wilms Eivor , Ebner Katharina , Brühl Marie-Luise von , Rausch Philipp , Baines John F. , Haberichter Sandra , Lämmle Bernhard , Binder Christoph J. , Jurk Kerstin , Ruggeri Zaverio M. , Massberg Steffen , Walter Ulrich , Ruf Wolfram , Reinhardt Christoph 
Published: June 2017

Key PointsVWF synthesis in liver endothelial cells is regulated by gut microbiota through TLR2 signaling. Reduced plasma VWF levels in GF and Tlr2−/− mice cause reduced thrombus formation at the ligation-injured carotid artery.