bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of preoperative depression on 2-year clinical outcomes following adult spinal deformity surgery: the importance of risk stratification based on type of psychological distress
Authors: Theologis Alexander A. , Ailon Tamir , Scheer Justin K. , Smith Justin S. , Shaffrey Christopher I. , Bess Shay , Gupta Munish , Klineberg Eric O. , Kebaish Khaled , Schwab Frank , Lafage Virginie , Burton Douglas , Hart Robert , Ames Christopher P. , _ _ 
Published: May 2016

OBJECTIVE
The objective of this study was to isolate whether the effect of a baseline clinical history of depression on outcome is independent of associated physical disability and to evaluate which mental health screening tool has the most utility in determining 2-year clinical outcomes after adult spinal deformity (ASD) surgery.

METHODS
Consecutively enrolled patients with ASD in a prospective, multicenter ASD database who underwent surgical intervention with a minimum 2-year follow-up were retrospectively reviewed. A subset of patients who completed the Distress and Risk Assessment Method (DRAM) was also analyzed. The effects of categorical baseline depression and DRAM classification on the Oswestry Disability Index (ODI), SF-36, and Scoliosis Research Society questionnaire (SRS-22r) were assessed using univariate and multivariate linear regression analyses. The probability of achieving ≥ 1 minimal clinically important difference (MCID) on the ODI based on the DRAM’s Modified Somatic Perceptions Questionnaire (MSPQ) score was estimated.

RESULTS
Of 267 patients, 66 (24.7%) had self-reported preoperative depression. Patients with baseline depression had significantly more preoperative back pain, greater BMI and Charlson Comorbidity Indices, higher ODIs, and lower SRS-22r and SF-36 Physical/Mental Component Summary (PCS/MCS) scores compared with those without self-reported baseline depression. They also had more severe regional and global sagittal malalignment. After adjusting for these differences, preoperative depression did not impact 2-year ODI, PCS/MCS, or SRS-22r totals (p > 0.05). Compared with those in the “normal” DRAM category, “distressed somatics” (n = 11) had higher ODI (+23.5 points), lower PCS (−10.9), SRS-22r activity (−0.9), and SRS-22r total (−0.8) scores (p ≤ 0.01), while “distressed depressives” (n = 25) had lower PCS (−8.4) and SRS-22r total (−0.5) scores (p < 0.05). After adjusting for important covariates, each additional point on the baseline MSPQ was associated with a 0.8-point increase in 2-year ODI (p = 0.03). The probability of improving by at least 1 MCID in 2-year ODI ranged from 77% to 21% for MSPQ scores 0–20, respectively.

CONCLUSIONS
A baseline clinical history of depression does not correlate with worse 2-year outcomes after ASD surgery after adjusting for baseline differences in comorbidities, health-related quality of life, and spinal deformity severity. Conversely, DRAM improved risk stratification of patient subgroups predisposed to achieving suboptimal surgical outcomes. The DRAM’s MSPQ was more predictive than MCS and SRS mental domain for 2-year outcomes and may be a valuable tool for surgical screening.
Development of SSR markers for Psychotria homalosperma (Rubiaceae) and cross‐amplification in four other species
Authors: Sugai Kyoko , Watanabe Kenta , Kato Hidetoshi , Sugawara Takashi 
Published: May 2016

Premise of the study:Twenty‐six microsatellite (simple sequence repeat [SSR]) markers were characterized in Psychotria homalosperma (Rubiaceae), an endemic evergreen tree in the Bonin Islands, Japan, to investigate the genetic structure and gene flow of the species.Methods and Results:Using next‐generation sequencing, we developed 26 SSR markers for P. homalosperma with perfect motifs from di‐ to pentanucleotide repeats. Of these, the Chichijima and Hahajima island populations of P. homalosperma had mean allele numbers of 6.50 and 6.81, respectively. The mean expected heterozygosities were 0.578 and 0.606, respectively. In addition, 10 and eight of these markers were successfully amplified for P. boninensis and P. serpens, respectively, occurring in the same or adjacent areas.Conclusions:The SSR markers developed in this study will be useful for future studies concerning the population genetics of P. homalosperma and will facilitate the development of a conservation strategy.
DUAL STELLAR HALOS IN THE STANDARD ELLIPTICAL GALAXY M105 AND FORMATION OF MASSIVE EARLY-TYPE GALAXIES
Authors: Lee Myung Gyoon , Jang In Sung 
Published: May 2016

ABSTRACT
M105 is a standard elliptical galaxy, located in the Leo I Group. We present photometry of the resolved stars in its inner region at R ≈ 4′ ≈ 4R
eff, obtained from F606W and F814W images in the Hubble Space Telescope archive. We combine this with photometry of the outer region at R ≈ 12′ ≈ 12R
eff from archival imaging data. Color–magnitude diagrams of the resolved stars in the inner region show a prominent red giant branch (RGB) with a large color range, while those for the outer region show better a narrow blue RGB. The metallicity distribution function (MDF) of the RGB stars shows the existence of two distinct subpopulations: a dominant metal-rich population (with a peak at [M/H] ≈ 0.0) and a much weaker metal-poor population (with a peak at [M/H] ≈ −1.1). The radial number density profiles of the metal-rich and metal-poor RGB stars are fit well by a Sérsic law with n = 2.75 ± 0.10 and n = 6.89 ± 0.94, and by a single power law (σ ∝ R
−3.8 and σ ∝ R
−2.6), respectively. The MDFs of the inner and outer regions can be described well by accretion gas models of chemical evolution with two components. These provide strong evidence that there are two distinct stellar halos in this galaxy, blue metal-poor and red metal-rich halos, consistent with the results based on globular cluster systems in bright early-type galaxies (ETGs). We discuss the implications of these results with regard to the formation of massive ETGs in the dual halo mode formation scenario.
CONSTRAINTS ON THE ARCHITECTURE OF THE HD 95086 PLANETARY SYSTEM WITH THE GEMINI PLANET IMAGER
Authors: Rameau Julien , Nielsen Eric L. , Rosa Robert J. De , Blunt Sarah C. , Patience Jenny , Doyon René , Graham James R. , Lafrenière David , Macintosh Bruce , Marchis Franck , Bailey Vanessa , Chilcote Jeffrey K. , Duchene Gaspard , Esposito Thomas M. , Hung Li-Wei , Konopacky Quinn M. , Maire Jérôme , Marois Christian , Metchev Stanimir , Perrin Marshall D. , Pueyo Laurent , Rajan Abhijith , Savransky Dmitry , Wang Jason J. , Ward-Duong Kimberly , Wolff Schuyler G. , Ammons S. Mark , Hibon Pascale , Ingraham Patrick , Kalas Paul , Morzinski Katie M. , Oppenheimer Rebecca , Rantakyearö Fredrik T. , Thomas Sandrine 
Published: May 2016

ABSTRACT
We present astrometric monitoring of the young exoplanet HD 95086 b obtained with the Gemini Planet Imager between 2013 and 2016. A small but significant position angle change is detected at constant separation; the orbital motion is confirmed with literature measurements. Efficient Monte Carlo techniques place preliminary constraints on the orbital parameters of HD 95086 b. With 68% confidence, a semimajor axis of

au and an inclination of

are favored, with eccentricity less than 0.21. Under the assumption of a coplanar planet–disk system, the periastron of HD 95086 b is beyond 51 au with 68% confidence. Therefore, HD 95086 b cannot carve the entire gap inferred from the measured infrared excess in the SED of HD 95086. We use our sensitivity to additional planets to discuss specific scenarios presented in the literature to explain the geometry of the debris belts. We suggest that either two planets on moderately eccentric orbits or three to four planets with inhomogeneous masses and orbital properties are possible. The sensitivity to additional planetary companions within the observations presented in this study can be used to help further constrain future dynamical simulations of the planet–disk system.
SIGNIFICANT ENHANCEMENT OF H2 FORMATION IN DISK GALAXIES UNDER STRONG RAM PRESSURE
Authors: Henderson Benjamin , Bekki Kenji 
Published: May 2016

ABSTRACT
We show for the first time that H2 formation on dust grains can be enhanced in disk galaxies under strong ram pressure (RP). We numerically investigate how the time evolution of H i and H2 components in disk galaxies orbiting a group/cluster of galaxies can be influenced by the hydrodynamical interaction between the gaseous components of the galaxies and the hot intracluster medium. We find that compression of H i caused by RP increases H2 formation in disk galaxies before RP rapidly strips H i, cutting off the fuel supply and causing a drop in H2 density. We also find that the level of this H2 formation enhancement in a disk galaxy under RP depends on the mass of its host cluster dark matter halo, the initial positions and velocities of the disk galaxy, and the disk inclination angle with respect to the orbital plane. We demonstrate that dust growth is a key factor in the evolution of the H i and H2 mass in disk galaxies under strong RP. We discuss how the correlation between H2 fractions and surface gas densities of disk galaxies evolves with time in the galaxies under RP. We also discuss whether galaxy-wide star formation rates (SFRs) in cluster disk galaxies can be enhanced by RP if the SFRs depend on H2 densities.
Role of Prostaglandin E2 in the Modulation of Wnt Canonical Signaling in Cells on Microstructured Titanium Surfaces
Authors: Manfredi Edoardo , Lumetti Simone , Rivara Federico , Toffoli Andrea , Calciolari Elena , Cacchioli Antonio , Ravanetti Francesca , Ghiacci Giulia , Macaluso Guido , Galli Carlo 
Published: May 2016

Background Rough surface topography enhances the activation of Wnt canonical signaling, a pathway required for osteoblast differentiation. The present study investigated the effects of the modulation of prostaglandin E2 (PGE2) signaling on osteoblastic differentiation on titanium surfaces for endosseous implants with different topographies. Methods C2C12 cells were plated on polished or acid-etched/sand-blasted (SLA) titanium discs and stimulated with 1 μM PGE2 or 100 nM cyclooxygenase inhibitor indomethacin. Activation of Wnt canonical signaling was measured with a reporter system. Gene expression was measured in the same cell system by real-time polymerase chain reaction (RT-PCR). Osteoblastic MC3T3 cells were then plated on polished or SLA titanium discs with or without indomethacin, and their proliferation and the expression of osteoblast-specific genes was assessed by RT-PCR. Cell morphology was furthermore studied on SEM, and cell adhesion was assessed by fluorescent labeling of focal adhesion. Results PGE2 decreased Wnt signaling stimulation in cells growing on polished or SLA surfaces, while indomethacin increased the expression of Wnt target genes in C2C12 and MC3T3 cells, by reporter assay. Moreover, indomethacin increased the expression of early differentiation marker alkaline phosphatase in MC3T3 cells on polished discs and of late marker osteocalcin in cells on SLA titanium. Conclusions Prostaglandin signaling affects the activation of Wnt canonical pathway in osteoblastic and mesenchymal cells on microstructured surfaces.
Do Adhesive Systems Influence the Color Match of Resin Composites?
Authors: Ritter Débora D. , Rocha Rachel O. , Soares Fabio Z.M. , Lenzi Tathiane L. 
Published: May 2016

Background This in vitro study evaluated the influence of adhesive systems on the color match of a resin composite with different translucencies. Methods Sixty disk-shaped specimens were made with A2 and opaque A2 (OA2) shades of nanohybrid resin composite Z250 XT. Specimens of each shade (n = 30) were randomly reassigned to 3 subgroups according to adhesive system: a 2-step etch-and-rinse adhesive (Adper Single Bond Plus), a 2-step self-etch system (Clearfil SE Bond) and a universal adhesive (Scotchbond Universal Adhesive). The bonding agents were applied to resin composite specimens following the manufacturers’ recommendations. Additionally, 5 disk samples of each adhesive system were prepared. Colorimetric evaluation (CIE L*a*b* system) was performed immediately after polishing the sample and application of the adhesive systems. Color changes (ΔE and ΔE00) were calculated between 2 measurements. Color coordinates L*, a* and b* of the adhesive disks were also assessed. The data obtained were analyzed using ANOVA and Tukey's post hoc test (α = 0.05). Results The application of Scotchbond Universal Adhesive to the resin composite A2 shade resulted in the highest color change (p<0.01; ΔE = 3.1 ± 0.7 and ΔE00 = 1.8 ± 0.4). However, no significant difference was observed among adhesive systems when applied to the resin composite OA2 shade (p>0.05). Scotchbond Universal Adhesive revealed augmented yellowing and greening in comparison with other experimental groups. Conclusions The universal adhesive tested resulted in higher visually perceptible color changes when using a more translucent resin composite shade, but this was clinically acceptable.
Spiritual Support for Adolescent Cancer Patients: A Survey of Pediatric Oncology Centers in Italy and Spain
Authors: Proserpio Tullio , Veneroni Laura , Silva Matteo , Lassaletta Alvaro , Lorenzo Rosalia , Magni Chiara , Bertolotti Marina , Barisone Elena , Mascarin Maurizio , Jankovic Momcilo , D'Angelo Paolo , Clerici Carlo A. , Garrido-Colino Carmen , Gutierrez-Carrasco Ignacio , Echebarria Aizpea , Biondi Andrea , Massimino Maura , Casale Fiorina , Tamburini Angela , Ferrari Andrea 
Published: May 2016

Introduction Spirituality is a fundamental aspect of the psychological well-being of adolescents with cancer. This study reports on a survey conducted at pediatric oncology centers in Italy and Spain to examine the situation concerning the provision of spiritual support. Methods An ad hoc questionnaire was distributed including multiple-choice questions on whether or not spiritual support was available; the spiritual counselor's role; how often the spiritual counselor visited the unit; and the type of training this person had received. Results A spiritual support service was available at 24 of the 26 responding centers in Italy and 34/36 in Spain. The training received by the spiritual counselor was exclusively theological in most cases (with medical or psychological training in a few cases). In both countries the spiritual counselor was mainly involved in providing religious services and support at the terminal stage of the disease or in talking with patients and families. Cooperation with caregivers was reported by 27.3% and 46.7% of the Italian and Spanish centers, respectively, while the daily presence of the chaplain on the ward was reported by 18.2% and 26.7%. Conclusions The role of the spiritual counselor in pediatric oncology – in Italy and Spain at least – is still neither well-established nor based on standardized operating methods or training requirements. A model that implies the constant presence of a spiritual counselor in hospital wards may be proposed to provide appropriate spiritual support to adolescents with cancer.
Clark's Ferry and Tavern: Gateway to the Juniata Valley
Authors: Hart Victor A. , Wilson Jason L. 
Published: May 2016

ABSTRACT
The evolution of the transportation history of the Commonwealth can be viewed at the confluence of the Susquehanna and Juniata rivers where in 1790 John Clark built a tavern and a ferry to transport travelers across the rivers. While the ferry system has been replaced by the current Clark's Ferry Bridge, the 1790 wood and stone tavern structure remains as one of the oldest buildings in the town of Duncannon. Archaeological and historical information can be gleaned from this important structure, which retains a vast amount of its 1790–1800 integrity. It stands as a reminder of the days of the packhorse, stagecoach, Conestoga wagon, canal boats, railroads, and automobiles at the entrance to the Juniata Valley.
The Anabaptists of Juniata County: A Historical Profile
Authors: Landis Betty Ann 
Published: May 2016

ABSTRACT
The Anabaptist story in Juniata County begins with Johannes Kröebiel Jr., a young, ambitious Swiss Mennonite seeking a wider place in the New World. In the 1770s Johannes began to carve a future for his own family and succeeding generations on central Pennsylvania's frontier land. Within the next century, Mennonite, Amish, Brethren, and Brethren-in-Christ groups had growing settlements in the beautiful Juniata Valley. Today dozens of Anabaptist congregations of various affiliations have found their home in the rural county and the saga of faith continues. Their story is similar to Anabaptist settlement in other central and western Pennsylvania rural counties.
Evaluation of the 3M™ Petrifilm™ Rapid Aerobic Count Plate for the Enumeration of Aerobic Bacteria: Collaborative Study, First Action 2015.13
Authors: Bird Patrick , Flannery Jonathan , Crowley Erin , Agin James , Goins David , Jechorek Robert ,   Collaborators:, Angeles K , Beers K , Brahmanda B , Brandt A , Brooks R , Brown B , Cuthbert N , Fagundes C , Gonzales K , Hankins A , Hardrath L , Kupski B , Lopez C , Marchant-Tambone J , Mastalerz A , McMahon W , Meyer J , Miller K , Morris A , Payne-McDaniel K , Pickett J , Reynolds J , Rodgers R , Schoeni J , Thompson L , Wright H 
Published: May 2016

Abstract
The 3M™ Petrifilm™ Rapid Aerobic Count (RAC) Plate is a sample-ready culture medium system containing dual-sensor indicator technology for the rapid quantification of aerobic bacteria in food products. The 3M Petrifilm RAC Plate was compared to the U.S. Food and Drug Administration Bacteriological Analytical Manual (FDA BAM) Chapter 3 (Aerobic Plate Count) for the enumeration of aerobic bacteria in raw easy-peel shrimp and the Standard Methods for the Examination of Dairy Products (SMEDP) Chapter 6 (Standard Plate Count Method) for the enumeration of aerobic bacteria in pasteurized skim milk and instant nonfat dry milk (instant NFDM). The 3M Petrifilm RAC Plate was evaluated using a paired study design in a multilaboratory collaborative study following current AOAC validation guidelines. Three target contamination levels (low, 10–100 CFU/g; medium, 100–1000 CFU/g; and high 1000–10 000 CFU/g) were evaluated for naturally occurring aerobic microflora for each matrix. For raw easy-peel shrimp, duplicate 3M Petrifilm RAC Plates were enumerated after 24 ± 2 h incubation at both 32 and 35°C. Pasteurized skim milk 3M Petrifilm RAC Plates were enumerated after 24 ± 2 h incubation at 32°C, and instant NFDM 3M Petrifilm RAC Plates were enumerated after 48 ± 3 h incubation at 32°C. No statistical difference was observed between 3M Petrifilm RAC Plate and FDA BAM or SMEDP reference methods for each contamination level.
Avaliação da relação velocidade-precisão em função do nível de dificuldade no transtorno de Asperger
Authors: Silva Deise Mara Mota , Ribeiro Denise Cardoso , Rezende Gilda Pena de , Silva Talita Dias da , Monteiro Carlos Bandeira De Mello , Trevizan Isabela Lopes , Wajnsztejn Alessandra Bernardes Caturani , Massetti Thais 
Published: May 2016

Introdução: O Transtorno de Asperger (TA) é considerado um distúrbio do neurodesenvolvimento, caracterizado por deficiências sociais, dificuldade de comunicação, padrões restritos e repetitivos de comportamento. Objetivo: Comparar o desempenho motor na realização de tarefa computacional com base na relação velocidade e precisão, entre pessoas com desenvolvimento típico e com TA, por meio do tempo de movimento. Métodos: Participaram deste estudo oito meninos com diagnóstico de TA e oito meninos com desenvolvimento típico, pareados por idade e sexo, para compor o grupo controle. A tarefa que utilizamos avalia a relação velocidade e precisão de movimento, que consiste na realização de movimentos manuais direcionados a um alvo, em três índices de dificuldade (ID). O tempo de movimento foi obtido por meio da divisão entre segundos pré-estabelecidos para a tarefa (10) e o número de toques realizados no alvo. A ANOVA para medidas repetidas foi utilizada para a comparação entre os ID e entre os grupos. Resultados: Observamos que o tempo de movimento aumentou conforme o progresso dos ID. Conclusão: Os indivíduos com TA apresentaram um tempo de movimento significativamente maior quando comparados ao grupo controle, em todos os ID. Supõe-se que há dificuldades inerentes à doença, e condições motoras dos indivíduos com TA limitam o desempenho durante a tarefa.
Impacto do diabetes mellitus gestacional sobre a massa placentária humana
Authors: Reginatto Cleiton Jonei , Subtil Vinicius Mazzetti , Rodrigues Lisandra Vieira , Valenti Vitor Engrácia , Abreu Luiz Carlos de , Gomes Rayana Loch , Petenusso Marcio 
Published: May 2016

Introdução: O diabetes mellitus gestacional (DMG) é uma alteração patológica do metabolismo energético materno desencadeado pela incapacidade da gestante produzir quantidades suficientes de insulina para compensar a intolerância à glicose desencadeada pela ação do hormônio lactogênio placentário (HPL). Tendo em vista que os níveis plasmáticos do HPL são proporcionais à massa da placenta e que eles são máximos próximo ao período em que a placenta adquire seu maior tamanho e período que a hiperglicemia se manifesta na gestante com DMG, é possível inferir que talvez exista correlação entre a massa placentária e essa doença. Objetivo: Avaliar se existe correlação entre o DMG e a massa placentária. Métodos: Pesquisa descritiva, transversal e com abordagem quantitativa, que foi realizada em um hospital público de Santa Catarina, Brasil. A pesquisa incluiu 20 mulheres grávidas, 10 com e 10 sem DMG, que concordaram em participar do estudo. Resultados: A média das massas das placentas do Grupo Controle foi de 505,63±12,18 g, enquanto a do grupo com DMG foi de 561,00 ±14,25 g. Conclusão: Este estudo sugere que a massa placentária das gestantes com DMG é significativamente maior do que a massa das placentas das gestantes hígidas.
Aptidão física relacionada à saúde de escolares com idade de 7 a 10 anos
Authors: Montoro Ana Paula Pietro Nobre , Leite Carina Raffes , Espíndola Janine Aryadine , Alexandre Juliano Maestri , Reis Monalisa Da Silva , Capistrano Renata , Lisboa Tailine , Beltrame Thais Silva 
Published: May 2016

Introdução: A aptidão física relacionada à saúde refere-se às características físicas e fisiológicas que definem os perfis de morbimortalidade. Objetivo: Avaliar a aptidão física relacionada à saúde de escolares entre 7 e 10 anos. Métodos: Participaram do estudo 93 crianças de 7 a 10 anos de ambos os sexos. O instrumento utilizado foi a bateria de testes e medidas do Projeto Esporte Brasil (PROESP-BR) contendo teste de flexibilidade, resistência muscular, resistência cardiorrespiratória e índice de massa corporal (IMC), “peso/altura2”. Resultados: Percebe-se que os escolares apresentaram níveis desejados de aptidão física nos testes de flexibilidade e IMC; no entanto, nos testes de resistência muscular e cardiorrespiratória, os escolares obtiveram níveis indesejados, considerando risco à saúde. Conclusão: Os resultados observados não apresentam níveis satisfatórios de aptidão física relacionada à saúde em resistências muscular e cardiorrespiratória, revelando um risco de desenvolvimento de doenças crônicas não transmissíveis aos escolares.