bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naproxen adjunct to fluoxetine for moderate‐to‐severe obsessive‐compulsive disorder: A randomized, double‐blind, placebo‐controlled trial
Authors: Shamabadi Ahmad , Motavalian Zahra , Farahmand Yalda , Farahmand Kimia , Arabzadeh Bahri Razman , Askari Sanaz , Ansari Sahar , Fallahzadeh Mohammadali , Shalbafan Mohammdreza , Akhondzadeh Shahin 
Published: October 2024

AimCurrent treatments for obsessive‐compulsive disorder (OCD) encounter resistance and limiting adverse events, necessitating novel therapeutic strategies. This study aimed to investigate the benefits of naproxen, a medication with effects on inflammation and neuronal function, on OCD.MethodsOne hundred and four OCD outpatients with a Yale‐Brown Obsessive‐Compulsive Scale (Y‐BOCS) score of >21 were equally assigned to receive fluoxetine plus either naproxen 250 mg or matched placebo q12hr. Patients were assessed using the Y‐BOCS by recording the subscale scores at baseline and weeks 5 and 10 to evaluate efficacy. They were also assessed in terms of tolerability.ResultsData from 96 patients were analyzed. The baseline characteristics were comparable between the groups. There were significant time‐treatment interaction effects on the obsession subscale ( = 0.055) and total ( = 0.043) scores of Y‐BOCS. Reductions in the obsession subscale and total scores of Y‐BOCS were significantly greater in the fluoxetine plus naproxen group until the endpoint (Cohen's d = 0.560 and Cohen's d = 0.477, respectively). However, the difference in compulsion subscale score changes between the groups was not significant. Respondents with a reduction of ≥35% in Y‐BOCS total scores were significantly more in the fluoxetine plus naproxen group (80.0% versus 47.8%). The side effect frequencies were comparable between the groups.ConclusionNaproxen, adjunct to fluoxetine, outperformed adjunctive placebo in treating obsession and total symptoms of OCD patients in a safe and tolerable manner.Clinical trial registrationThe study protocol was registered and published in the Iranian Registry of Clinical Trials (http://www.irct.ir; registration number IRCT20090117001556N139).
Emerging Contaminants Related to Brazilian Aquaculture
Authors: da Mota Juliana Barros , Neves Thiago de Alencar , da Costa Daniel Pereira , Starling Maria Clara Vieira Martins , de Amorim Camila Costa , Miranda‐Filho Kleber Campos 
Published: October 2024

ABSTRACTResearch efforts around the world have focused on identifying the occurrence of emerging contaminants in aquaculture areas. In the Brazilian context, studies have aimed to identify emerging contaminants in water used for this activity. This systematic review covered studies published without a specific time frame with the following criteria: research conducted in aquaculture areas or with species and cultured water in Brazil and analysis of emerging contaminants. Out of the 42 studies identified, 132 emerging contaminants were observed. The Southeast and South regions accounted for most of these studies, with limited research conducted in the North and Northeast regions. Tilapia was the most studied species, followed by mollusks. In toxicity tests, animals showed several effects, such as decreased oxygen consumption and swimming patterns, histopathological changes, inhibition of sperm production, cardiac edema, spinal deformity, and antimicrobial resistance. In conclusion, advancements in research on emerging contaminants in Brazilian aquaculture are needed as the number of existing studies is lower compared to global numbers. Few studies have focused on analyzing cultivation sites to identify the contaminants present and their sources. Also noteworthy is the scarcity of work in the Northern region of Brazil and on native species. Characterizing these environments in terms of the types of contaminants and main sources of contamination is essential to finding ways to mitigate ecological and human health risks, as well as developing specific legislation for these contaminants because they are currently not part of routine monitoring programs and are therefore not regulated, especially in aquaculture environments.
Two draft genomes of fungal leaf endophytes from tropical gymnosperms
Authors: Villarreal Aguilar Juan Carlos , Meléndez Omayra , Bethancourt Rita , Bethancourt Ariadna , Rodríguez-Castro Lilisbeth , Mendieta Jorge , Durant Armando , Vargas Marta , Sedio Brian , Saltonstall Kristin 
Published: October 2024

ABSTRACT

Two ascomycetes,
Neofusicoccum
sp. and
Xylaria
sp.
,
were isolated from healthy leaves of the tropical gymnosperms
Zamia pseudoparasitica
(Z2) and
Zamia nana
(Z50) from Panama. The two draft genomes possess a broad predicted repertoire of carbohydrate-degrading CAZymes, peptidases, and secondary metabolites, with more secondary metabolite clusters in the
Xylaria
isolate.
Draft genome sequence of
Nocardia
sp. strain JMUB6875 isolated from a patient with disseminated nocardiosis
Authors: Suzuki Takayuki , Watanabe Shinya , Seto Nayuta , Honjo Momori , Cui Longzhu , Hatakeyama Shuji 
Published: October 2024

ABSTRACT

We report the draft genome sequence of the
Nocardia
sp. strain JMUB6875, isolated from a blood culture specimen of a patient with disseminated nocardiosis. This strain appears to be a potentially novel species closely related to
Nocardia concava
.
Subtyping stage 3 epiretinal membrane: a comprehensive study of ectopic inner foveal layers architecture and its clinical implications
Authors: Huang Yanqiao , Wang Qiong , Li Xiaofang , Zhao Xiujuan , Huang Xinhua , Ma Wei , Yu Shanshan , Lu Lin , Ding Xiaoyan , Sun Limei 
Published: October 2024

AimsTo evaluate the visual function and foveal architecture in patients with stage 3 idiopathic epiretinal membrane (iERM).MethodsA cross-sectional observational study included 56 eyes of 52 patients with stage 3 iERM. The patients were classified into type A ectopic inner foveal layers (EIFL) and type B EIFL based on the presence of a continuous hyporeflective band. Visual function and foveal microarchitecture were assessed in enrolled eyes. Best-corrected visual acuity (BCVA), metamorphopsia scores, retinal sensitivity and optical coherence tomography (OCT)/OCT angiography features were compared between two subtypes.ResultThe BCVA in type A EIFL and type B EIFL was 0.22 logarithm of minimal angle of resolution (logMAR) (0.15 logMAR, 0.40 logMAR) and 0.53±0.23 logMAR, respectively (p=0.002). Type B EIFL had higher average metamorphopsia scores, especially horizontal metamorphopsia scores, than type A (p=0.013, p=0.007, respectively). Type B EIFL had worse central 2° foveal sensitivity than type A (p=0.034). Type B EIFL had thicker central foveal thickness and EIFL thickness (514.08±73.80 µm vs 444.41±56.57 µm, p=0.001; 159.75±78.30 µm vs 48.44±18.37 µm, p<0.0001; respectively). The foveal avascular zone area of type B EIFL was smaller than that of type A (0.042±0.022 mm2vs 0.077±0.039 mm2, p<0.0001). The vessel density and flow area of the superficial vascular complex in type B EIFL were larger than those in type A (both p=0.001).ConclusionsType B EIFL demonstrated significantly worse visual function than type A EIFL, along with marked differences in foveal microstructure and microvasculature. Our study complements the current staging of iERM and helps determine the optimal timing of iERM surgery.
Evaluation of a new classification system for measuring the progression of ocular cystinosis: an analysis of 64 patients
Authors: Liang Hong , Baudouin Christophe , Giordano Vincenzo 
Published: October 2024

AimsTo analyse the correlation between the physician categories defined by the 3C classification (crystal-complication-compliance) and the ocular manifestations of nephropathic cystinosis.MethodsThe last visit data of 64 patients aged between 2 and 64 attending the centre for management of cystinosis were reviewed. Each patient had been placed into one of four categories by the clinician based on disease severity. The correlation between these categories and markers of the disease was assessed using Pearson’s correlation.ResultsPhotophobia (0.647, p<0.001), visual acuity (−0.695, p<0.001), Gahl’s score (0.603, p<0.001), optical coherence tomography (OCT)% (0.713, p<0.001) and in vivo confocal microscopy (IVCM)% (0.845, p<0.001), showed a strong, highly significant correlation between key signs and symptoms and the 3C classification. Corneal complications were strongly correlated with the 3C classification with scores of 0.802 (p<0.001), 0.634 (p<0.001), 0.726 (p<0.001) and 0.677 (p<0.001) for band keratopathy, keratitis, neovascularisation and corneal ulceration, respectively. 75% of those classified as most severe had all four complications. The use of artificial tears and ciclosporin strongly correlated with the categorisation, 0.574 (p<0.001) and 0.631 (p<0.001), respectively. With all cystinosis markers, the 3C classification showed a stronger correlation than age and crystal scores by Gahl’s and OCT. Category and age were strongly correlated (0.656, p<0.001). There was a moderate negative correlation with therapeutic compliance with cysteamine eye-drops and categorisation (−0.422, p<0.001). The compliance pattern observed may help to explain why the disease progresses in some patients.Conclusion3C classification is a reliable tool to categorise ocular cystinosis and can support clinical management decisions allowing more reliable comparison of datasets.
Sympathetic ophthalmia: epidemiology and cohort-based assessment of clinical outcomes
Authors: Patterson Tim J , Gu Weidong , Eliason David , Rojas-Carabali William , Lee Bernett , Mahendradas Padmamalini , Biswas Jyotrimay , Majumder Parthopratim Dutta , Agarwal Manisha , Pavesio Carlos , Gupta Vishali , Agrawal Rupesh , Blanch Richard James 
Published: October 2024

Background
The purpose of this study was to report the incidence, time after inciting event, aetiology and risk after specific intraocular procedures and the visual outcomes associated with sympathetic ophthalmia (SO) occurrence.

Methods
This study reports data from multiple retrospective cohorts: retrospective population-based data were extracted from the TRICARE service network (between 2017 and 2021) and retrospective case-based data from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database (cohorts from the UK, South India and North India).

Results
There were 159 patients with SO identified. The length of time from sensitising event to SO occurrence was a median of 151 days (range: 6–9100 days).
In the TRICARE database, 2 patients developed SO after open globe trauma and primary repair (of 615 eyes, rate 0.33%; 95% CI 1.26% to 1.30%). None developed SO after vitrectomy (total of 23 903 events; 95% CI 0% to 0.012%). The combined North Indian and UK cohorts reported 78.6% (81 patients) after trauma, 18.45% (19 patients) after elective surgery.
Visual outcomes were reported in the OASIS database for 98.01% of patients (155 of 157 patients). The median presenting and final best corrected visual acuity (BCVA) for the inciting eye were no perception of light, the median presenting and final BCVA for the sympathising eye were 0.65 and 0.3 logMAR, respectively.

Conclusion
This study identified 159 cases of SO. With poor visual outcomes in the inciting eye, early diagnosis and management are crucial for optimising visual outcomes in the sympathising eye.
Health literacy and cumulative social disadvantage are associated with survival and transplant in patients with hepatocellular carcinoma: a prospective study
Authors: Nephew Lauren D. , Rawl Susan M , Carter Allie , Garcia Nicole , Monahan Patrick O , Holden John , Ghabril Marwan , Montalvan-Sanchez Eleazar , Patidar Kavish , Desai Archita P , Orman Eric , Chalasani Naga 
Published: October 2024

ObjectiveTo investigate how individual social determinants of health (SDOH) and cumulative social disadvantage (CSD) affect survival and receipt of liver transplant (LT) in patients with hepatocellular carcinoma (HCC).MethodsWe enrolled 139 adult patients from two Indianapolis hospital systems between June 2019 and April 2022. Structured questionnaires collected SDOH and social risk factor data. We compared SDOH and CSD by race, gender and disease aetiology, assigning one point per adverse SDOH. Multivariable competing risk survival analysis assessed associations between SDOH, CSD, survival and LT receipt.ResultsBlack patients experienced higher CSD than white patients in the cohort (5.4±2.5 vs 3.2±2.1, p<0.001). Black patients were significantly more likely to have household incomes <US$15 000 per year (52.6% vs 18.3%, p=0.003), to be insured by Medicaid (57.9% vs 33.0%, p=0.04), and to live in high Social Deprivation Index areas (68.4% vs 17.5%, p<0.001) than white patients. Patients with hepatitis C virus and alcohol-related liver disease had more adverse SDOH than those with metabolic dysfunction-associated steatotic liver disease, while there were no significant differences by gender. On multivariable analysis, a higher health literacy score was a significant predictor of survival (HR 2.54, 95% CI 1.19 to 5.43 CI, p=0.02) and higher CSD was associated with a lower probability of receipt of LT (HR 0.80, 95% CI 0.68 to 0.95, p=0.01).ConclusionsThere are significant racial and aetiology-related differences in SDOH burden. Low health literacy and high CSD are linked to worse outcomes in HCC patients. Health literacy screening and targeted interventions for those with high CSD could improve LT access and survival rates.
Comparative outcomes of selective laser trabeculoplasty delivered by optometrists compared with ophthalmologists: a UK-based multicentre observational study
Authors: Lee Chan Ning , Delaney Alexander , Richardson Jay A L , Freeman Graham , Gunn Patrick J G , Harthan Stephen , Dubois Vincent , Yau Kenneth , Hemmerdinger Christopher , Harper Robert , Vallabh Neeru A 
Published: October 2024

BackgroundSelective laser trabeculoplasty (SLT), a National Institute for Care and Health Excellence recommended first-line treatment for open-angle glaucoma and ocular hypertension, is increasingly delivered by optometrists. This retrospective multicentre observational study evaluates real-world outcomes of SLT comparing optometrist-treated to ophthalmologist-treated eyes.MethodsAdults aged ≥40 years receiving first SLT treatment at three UK hospital eye units (Aintree, Manchester, Macclesfield) between 1 August 2018 and 1 August 2021 were analysed using anonymised local audit data. Outcomes included intraocular pressure (IOP), visual acuity (VA), drop burden, complications including post-SLT IOP spikes, and composite treatment failures including repeat laser or glaucoma surgery, evaluated at 6-monthly intervals up to 24 months. Groups were compared with parametric and non-parametric tests, accounting for intereye correlation, and Kaplan-Meier survival analysis using composite treatment failure endpoints was conducted.Results207 eyes (131 patients) were analysed, 84 (56 patients) optometrist-treated eyes compared with 123 ophthalmologist-treated eyes (75 patients). No statistically significant differences (p>0.05) were found in change in VA, IOP or glaucoma drops from pre-SLT baseline between optometrist and ophthalmologist-treated eyes, at all time points. More cataracts were detected in optometrist-treated eyes, however, this did not affect differences in VA or cataract surgery frequency. More optometrist-treated eyes underwent glaucoma surgery, however, ophthalmologist-treated eyes had higher drop burden and chance of composite treatment failure up to month 18.ConclusionOutcomes of SLT treatment by optometrists and ophthalmologists are comparable up to 24 months post-treatment. Ophthalmologist-treated eyes may have had more aggressive eye-drop treatment, preventing the need for surgery.
Quality improvement approach to reduce patient cycle time at a student-run free healthcare clinical network
Authors: Kronlage René Marcella , Stanley Amy S , Reid Miranda J , Shaw William Hudson , House Cara E , Lossius Michele N , Kulla Artenisa , Coxen Kendyll , Mackie Phillip M , Holland Carolyn K 
Published: October 2024

BackgroundThe University of Florida (UF) Equal Access Clinic Network (EACN) is the largest student-run free healthcare clinic network in Florida. The UF EACN serves those who are underinsured or uninsured in Alachua County and its surrounding area. Nationally, average total clinic time per medical visit has been established to be 84 min.ProblemBefore this project, average patient cycle time at the UF EACN was 125.3 min, and there was no established quality improvement (QI) team to implement changes to address inefficiencies.MethodsThis was a prospective QI study that recorded patient cycle times for patients who received healthcare at any of the four primary care free clinics across the UF EACN from 5 July 2022 to 6 April 2023.InterventionsEighteen Plan–Do–Study–Act cycles were tailored to each of the four primary care clinic’s needs with a focus on reducing patient cycle time by addressing the following identified problems: prolonged intake process, translation services, limited numbers of volunteers, and other inefficiencies and bottlenecks in workflow.ResultsThe median patient cycle time at the EACN shifted from 125.3 min to 112.7 min over a nine month period. This drop of 12.6 min meant patients saw a 10.1% reduction in patient cycle time across the EACN.ConclusionUnderserved patients at EACN are experiencing increased value by having shorter patient cycle times.
Mean platelet volume in preterm infants as a predictor of late-onset neonatal sepsis: a retrospective comparative study
Authors: Leibovitch Leah , Zohar Hagar , Gavri-Beker Ayelet , Goshen Abigail , Strauss Tzipora 
Published: October 2024

BackgroundNeonatal sepsis remains a primary cause of morbidity and mortality among newborns. Rapid and accurate diagnosis poses a significant challenge—the non-specific clinical presentation of neonatal sepsis relies heavily on various laboratory indices for early detection and subsequent management. One such indicator under investigation is the mean platelet volume (MPV), which may serve as a predictive marker. This study aims to evaluate the association between the MPV and late-onset sepsis in preterm infants.MethodsThis retrospective study included 63 newborns born at Sheba Medical Center from 2016 to 2020 with late-onset sepsis as evidenced by positive blood cultures, and 63 newborns in the control group. We analysed blood count data at three intervals: preinfection, intrainfection and postinfection. Electronic medical records provided supplemental data. Each septic neonate was paired with a non-septic control.ResultsOur results revealed a significant elevation of MPV in septic newborns compared with non-septic controls during the days prior to the infection (9.323 and 8.876, respectively, p=0.043) and persisted up to 2 weeks postinfection (9.39 vs 8.714, p=0.025).The MPV and the MPV-to-total platelet (PLT) count ratio exhibited significant predictive capabilities in receiver operating characteristics analysis (−0.60 and −0.57, respectively).ConclusionsHigh MPV in combination with PLT decrement might be predictive for the diagnosis of late-onset sepsis. Future studies should be conducted in order to better understand the underlying pathophysiology and the potential clinical applications of these findings.
Australian women’s experiences and perceptions of interconception care: a qualitative descriptive study
Authors: Kodavaluru Sarmitha , Appuhamy Mudiyanselage Isini , Mazza Danielle , James Sharon 
Published: October 2024

BackgroundInterconception, the time between pregnancies, is an opportunity to improve the health outcomes of women, infants and subsequent pregnancies. Interconception care involves the assessment of previous pregnancy outcomes, management of maternal risk factors, advice regarding optimal pregnancy spacing, and postpartum contraception provision. However, there is no consistent provision of interconception care, and limited understanding of consumer perspectives. This study aims to describe Australian women’s perceptions and experiences of interconception care.MethodsA qualitative descriptive semi-structured interview study was undertaken in July 2022 with women of reproductive age who had given birth to at least one child with intention to have another child. Reflexive thematic analysis was conducted and the standards for reporting qualitative research informed the writing of this study.ResultsFrom 15 participants, analysis identified two major themes: (1) women’s lack of engagement with interconception care services; and (2) difficulties accessing interconception care. All participants were unfamiliar with interconception terminology, but most perceived it as a distinct care need, largely accessed in primary healthcare settings. Participants wanted further support to be initiated by healthcare professionals about issues such as breastfeeding, postpartum care and lifestyle risk reduction. Interconception care availability and content was perceived as inconsistent, ineffective and provided opportunistically. Participants outlined the need for improved consumer and healthcare professional interconception care awareness, education, and woman-centred continuity of care.ConclusionsInterconception care awareness is needed by women and healthcare professionals to better meet the needs of women during this life stage.
Influences on ethnic minority women’s experiences and access to contraception in the UK: a systematic qualitative evidence synthesis
Authors: Cory Ryan James , Mawson Rebecca , Linton Emma , Al-Bazz Dalal Y , Fryer Kate , Ma Richard , Mitchell Caroline Anne 
Published: October 2024

BackgroundAccessible contraception is critical for promoting the health and well-being of women and their families. In the UK, contraception is free at the point of access, but only 55% of pregnancies are planned, with negative implications for maternal and infant outcomes. In general, women from ethnic minorities use contraceptives less than white women. Barriers to the uptake of contraceptives have been identified, including perceived poor information from healthcare professionals and concerns about side effects. However, most studies do not include representative proportions of women from ethnic minorities. Evidence suggests that ethnic minority (EM) women feel targeted and coerced by healthcare professionals regarding contraception.MethodsA systematic search of Medline, Embase, and PsycINFO via Ovid, CINAHL, and Web of Science was conducted to identify primary qualitative and mixed-methods studies exploring ethnic minority women’s experience of contraception in the UK. The data were charted using thematic analysis, using both summary and synthesis.Results and conclusions16 studies met the inclusion criteria, including the perspectives of 717 participants from an ethnic minority. Four overarching themes were developed: contraceptive knowledge, beliefs, family, and services. Similar to women in general, ethnic minority women have concerns about side effects, especially infertility, value the perspectives of their peers and male partners, and express a preference for female healthcare professionals. Novel perspectives included conflicting ideas about the influence of religion and stereotyping of ethnic minority women. Culturally competent consultations and a better understanding of hormonal hesitancy are essential.