bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the clinical effect of kangaroo-style intervention mode on neonatal cerebral palsy treated with mouse nerve growth factor
Authors: Yang Hui , Sun Dan , Gao Chunling 
Published: September 2024

Purpose: To investigate the effect of application of kangaroo-style intervention mode on neonatal cerebral palsy treated with mouse nerve growth factor.
Methods: In this retrospective study, 153 newborns with cerebral palsy on admission to Wuhan Maternal and Child Healthcare Hospital, China between January 2016 and January 2020 were assigned to control group (n = 81) and study group (n = 72), based on differences in intervention schemes used. The control and study groups received mouse nerve growth factor and routine intervention, while study group received additional treatment with kangaroo-style intervention mode. After treatment, neonatal neurological function, intellectual development, intelligence development quotient, and growth and development indices were compared between the two groups.
Results: Scores on neurological function, mental development index and psychomotor development index, as well as intelligence development quotient were significantly higher in the study group than in the control group (p < 0.05). There were no significant differences in growth and development indices between the two groups (p > 0.05).
Conclusion: Kangaroo-style intervention mode effectively improves neurological function, and promotes intellectual development in cerebral palsy newborns treated with mouse nerve growth factor. However, it had no significant effect on neonatal physical development.
A meta-analysis of the efficacy of combining diquafosol tetrasodium with conventional therapy for dry eye disease
Authors: Yang Fengjiao , Li Xiang 
Published: September 2024

Purpose: To evaluate the safety and effectiveness of combining 3 % diquafosol tetrasodium (DQS) with conventional treatment in addressing dry eye disease (DED).
Methods: A comprehensive search was conducted in databases, including CNKI, VIP, WANFANG, CBM, DUXIU, PubMed, Embase, Cochrane, Web of Science, Ovid MEDLINE, Scopus, and ProQuest up to June 5, 2023. Thirteen relevant randomized controlled trials (RCTs) were included in the analysis. Odds ratios (ORs) were used for binary categorical variables, and standardized mean difference (SMD) was employed for continuous variables and presented with 95 % confidence intervals (CI). Publication bias was assessed using funnel plot diagrams and the Egger test.
Results: Combined treatment with 3 % DQS had significantly better efficacy than control group (that received conventional treatment alone) in improving clinical efficacy, prolonging tear film break-up time, increasing tear secretion volume, and reducing corneal fluorescent staining (p < 0.05). Furthermore, the treatment demonstrated a favorable safety profile.
Conclusion: In the management of dry eye disease, the inclusion of 3 % DQS displays better therapeutic effects and safety when compared to other alternative approaches. This study underscores the potential of DQS as a promising intervention for addressing the complex pathogenesis of DED. However, its long-term effectiveness and safety still need to be further evaluated.
Profile and factors associated with quality of life among outpatients with type 2 diabetes mellitus in Bali, Indonesia
Authors: Jaya Made Krisna Adi , Rahmawati Fita , Yasin Nanang Munif , Ikawati Zullies 
Published: September 2024

Purpose: To map the quality of life (QoL) profile of type 2 diabetes mellitus (T2DM) patients and identify its influencing factors in Bali Province.
Method: This study was conducted in the Pharmacy Department of two Government Hospitals in Bali Province, Indonesia. The 89 participants were T2DM patients undergoing outpatient therapy from November 2023 to February 2024. A cross-sectional design was used to determine the QoL of T2DM patients using SF-36 questionnaire. The medical and demographic data investigated were gender, age, BMI, glycemic profile, duration of DM, comorbidities, type of diabetes medication and history of severe hypoglycemia.
Results: The quality-of-life profile of T2DM patients in Bali Province was generally poor while undergoing diabetes therapy (QoL score: 44.77 ± 24.71). The influential factors that could be modified included a history of severe hypoglycemia, BMI, glycemic control and comorbidities, while the nonmodifiable factor was age.
Conclusion: Patients with T2DM undergoing therapy at the hospital polyclinics outpatients unit in Bali Province, Indonesia during the period of study had a relatively low QoL. Factors contributing to these outcomes include patients' history of severe hypoglycemia, age, diabetes complications, glycemic control and BMI. It would be necessary to analyze the influence of patients' behavior and motivation in receiving health services, support system conditions, compliance, and other social conditions on QoL.
Effect of the combination of radioiodine therapy and euthyrox in BRAF-mutated thyroid cancer post-total thyroidectomy
Authors: Fu Qiang , Huang Xueyang , Yang Yu , Huang Yalan 
Published: September 2024

Purpose: To investigate the effect of combining radioiodine therapy with euthyrox in treating thyroid cancer with BRAF gene mutation following total thyroidectomy (TT).
Methods: This retrospective study analyzed records of 98 differentiated thyroid cancer (TC) patients with BRAF gene mutation who underwent TT between February 2018 and January 2020 at Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China. The patients were randomized into control (46 patients) and study groups (53 patients). Control group received euthyrox, while the study group received euthyrox in addition to radioiodine following total thyroidectomy. Efficacy, thyroid function before and after treatment, incidence of adverse reactions, and 3-year recurrence rates were evaluated.
Results: The study group showed significantly higher overall response rate (ORR) compared to control group (p < 0.05). There were no significant differences in thyrotropin (TSH), free thyroxine (FT4), and free triiodothyronine (FT3) levels between the groups before treatment (p > 0.05). After treatment, both groups exhibited significant changes in thyroid function, with decreased TSH, and increased FT4 and FT3 levels (p < 0.05). Post-treatment TSH levels were significantly lower while FT4 and FT3 levels were significantly higher in the study group compared to control group (p < 0.05).
Conclusion: Combining radioiodine therapy and Euthyrox following total thyroidectomy enhances therapeutic outcomes in patients with BRAF-mutated TC, improves thyroid function and reduces recurrent risk without increasing adverse reactions. Further studies will aim to expand the sample size and stratify patients by severity to comprehensively validate these findings
Effect of <i>Lonicerae japonicae<i> caulis extract on the growth and apoptosis of human osteosarcoma U2OS cells
Authors: Dong XiaoWei , Yan RuShan , Yao QiJun , Lei Yu , Liang Haidong 
Published: September 2024

Purpose: To determine the effect of Lonicerae japonicae Caulis extract (LJCE) on the proliferation, apoptosis, and cycle distribution of human osteosarcoma U2OS cells.
Methods: Human osteosarcoma U2OS cells were treated with LJCE at doses of 10, 20, 30 and 40 mg/mL, with untreated U2OS cells as the control group. Cell proliferation was measured using MTT method, while flow cytometric analysis was used for determination of apoptosis and cell cycle distribution.
Results: As LJCE concentration increased, the viability of U2OS cells gradually decreased, while the apoptosis rate gradually increased. The LJCE treatment had no marked effect on G1 phase cells (p > 0.05). However, the population of G2 cells in each group increased with increasing LJCE concentration, while the S phase cells in each group decreased with increasing concentration. The cells were significantly blocked in the G2 phase (p < 0.05).
Conclusion: Lonicerae japonicae Caulis extract inhibits the proliferation of U2OS cells and promotes apoptosis of U2OS cells. Therefore, LJCE possesses potentials as a novel therapeutic agent for osteosarcoma.
Diversity of curcuminoids, bioactive compounds and antioxidant activities in three species of Curcuma
Authors: Papayrata Chanakran , Chumroenphat Theeraphan , Saensouk Piyaporn , Saensouk Surapon 
Published: September 2024

Purpose: To investigate the physical characteristics, bioactive compounds and antioxidant activities of curcuminoids, phenolic acids, and flavonoid compounds in three Curcuma species (C. mangga, C. zedoria, and C. longa).
Methods: Rhizomes of three Curcuma species (C. mangga, C. zedoria, and C. longa) were collected, and then curcuminoids, phenolics and flavonoid acids were determined using high performance liquid chromatography (HPLC) and liquid chromatography-mass spectroscopy. Antioxidant activities were assessed by 2,2- diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays.
Results: Variations in colour metrics such as lightness (L*), red-green (a*), and yellow-blue (b*) indicated different bioactive compounds. C. longa exhibited significantly higher concentration of curcuminoids (333.2 µg/g DW), total phenolic content (TPC, 116.7 mg GAE/g DW) and total flavonoid content (TFC, 16.1 mg RE/g DW) compared to C. mangga, and C. zedoria (p < 0.05). Furthermore, C. longa exhibited significantly higher antioxidant activity than C. mangga, and C. zedoria (p < 0.05).
Conclusion: The results indicate significant variations in bioactive composition between the three species of the genus Curcuma. Curcuma longa shows significantly higher concentration of curcuminoids, TPC, and TFC as well as antioxidant activity compared to C. mangga and C. zedoria. Future studies are required to examine the impact of natural variables, growing conditions, and processing techniques on the prevalence of bioactive chemicals and correlation with biological activities.
Porosity estimation using RHG approach and well log data from southern Niger Delta, Nigeria
Authors: Umoren E. B. , Atat J. G. , Akankpo A. O. , Usen I. C. 
Published: September 2024

Raw well data from oil wells A11, A22 and A33 in the southern parts of the Niger Delta (AXXField) were used for porosity estimation using the Raymer Hunt Gardner (RHG) technique. Using Microsoft Excel for analysis and computation of results, gamma ray log, sonic log with respect to depth were generated. The results of these curves were used to estimate porosity. The major outcomes resulting from this porosity estimation revealed that porosity ranges from 22.0% to 41.0%, 25.0% to 37.0% and 16.0% to 38.0% for wells A11, A22 and A33 respectively, with average values of about 33.5% for well A11, 30.1% for well A22 and 27.1% for well A33. Therefore, the average porosity obtained gives 30.2% in the AXX field. The result of this estimation belongs to the excellent class of porosity estimation. It shows that the available pore spaces in the oil reservoir zone are adequate for migration, that is, it can store and transmit fluid. These results show that an increase in sonic gives rise to an increase in porosity irrespective of the lithology.
Determination of unsafe distance of sound levels from a 65 kVA non-sound proof electric power generator
Authors: Ekott E. E. , Udokang E. E. 
Published: September 2024

No matter the power rating of a non-sound-proof electric power generator, it can generate sound that adversely affects residents if proper control measures are not implemented. This work presents the determination of unsafe distance of sound levels from a 65 kVA non-sound proof electric power generator for a better environment. All sound levels were measured using a sound level meter while, a distance, x of 5m interval from the generator was maintained using a measuring tape. The background sound levels, LBs were taken when the generator was switched off while, the average sound levels, LAvs were measured when the generator was switched on. The generator sound levels, LGs were calculated from the average and background sound levels. Finally, the data obtained were compared with the World Health Organization, (WHO) safety standards. The results showed that LAv and LG were not strongly correlated with LB. Here, a linear regression model of a plot of LAv against LB had a coefficient of determination, R2 = 0.069 while that of a plot of LG against LB had a coefficient of determination, R2=0.068. The results revealed that the adverse effects of the generator were beyond a distance of 65 m from it. This is because at x = 65 m, the generator sound level LG = 56.9 dBA which was greater than 55 dBA (WHO standard). It is recommended that a 65 kVA power generator of this type be installed from a distance of 70 m in residential areas.
Wprowadzenie do tematyki ‘Kopernik a astrologia’. Komentarz do tez Roberta S. Westmana
Authors: Kokowski Michał 
Published: September 2024

Artykuł stanowi wprowadzenie do tematyki „Kopernik a astrologia”. Przedstawiono przegląd zbioru faktów i stanowisk badaczy myśli Kopernika, które łączą się z tą tematyką, a także stanowisko autora. Kluczową rolę pełni krytyka tez R.S. Westmana.
Was Copernicus an Astrologer?
Authors: Borski George , Kolkov Ivan 
Published: September 2024

The question ‘Was Copernicus an astrologer’ is prima facie very clear, while in fact being quite ambiguous. This question should rather be regarded as a vast topic covering lots of more concise questions such as ‘Was Copernicus thoroughly educated in astrology?’, ‘Did Copernicus believe in astrology?’ or ‘Did a mature Copernicus practice astrology?’
Unfortunately, thus far, consensus has not been achieved among historians on any of them. Accordingly, the topic has been for some time, and still is, a battlefield of the most acrimonious debates in Copernicology, nay, perhaps in the whole history of science.
Carefully made distinctions and subsequent analysis of the common pro et contra arguments enabled this paper to arbitrate the different perspectives. None of the arguments has been found to have a decisive force. In general, while the pro lines of reasoning are normally based upon insecure or even faulty inductive logic, their contra counterparts often suffer from ex silentio inferences or even ad ignorantiam fallacy.
Two new, subtle arguments have been introduced instead. They can be considered as genuine new evidence allowing for the resolution of some lingering doubts. First, the natal charts of Copernicus that were cast in the middle of the 16th century have been studied. The excessively exact birth hour of Copernicus at 4:48 PM has quite naturally been expected to be a result of a preliminary astrological rectification. However, apparently it was not rectified by the algorithms most popular at the time. The findings suggest the number-symbolic rather than astrological inclinations of Copernicus.
Further, a careful analysis of Copernicus’s annotations in the Alfonsine Tables revealed a link between the misprints corrected by him and the ancient observations he included in De Revolutionibus. Consequently, an extensive astrological use of the tables by him can be excluded with a high probability. Moreover, Copernicus likely never used Regiomontanus Tables on a regular basis either.
The conclusion integrates all the available arguments pertinent to the relationship of Copernicus with astrology.
Ukraińskie zapożyczenie kołtun w polskiej terminologii medycznej
Authors: Jankowiak Lucyna Agnieszka 
Published: September 2024

Kołtun jako zjawisko medyczne oraz języ­kowo-kulturowe był już przedmiotem wielu publikacji. Niniejszy artykuł dotyczy dotąd nieopisanego aspektu w rozwoju tego leksemu, tzn. jego obecności w polskiej terminologii medycznej, zwłaszcza w XIX i na początku XX wieku.
Kołtun, wyraz zapożyczony w XVI stuleciu z języka ukraińskiego w znaczeniu choroby, od razu uzyskał status terminu medycznego. Jest przykładem wyrazu, który z po­wo­dów pozajęzykowych (z oficjalnej medycyny zniknęła taka jednostka chorobowa) ostatecznie traci rangę nauko­­wego terminu. Dzięki analizie materiałów z różnych słowników (głównie medycznych) oraz z literatury medycznej, okazało się również, że rangę terminu naukowego kołtun traci zna­cz­nie później (1. połowa XX wieku) niż kołtun przestaje być przez naukowe środowisko trakto­­wany jako jednostka chorobowa lub objaw chorobowy (2. połowa XIX wieku).
The Kitchen and the Dacha: Productive Spaces of Soviet Mathematics
Authors: Gerovitch Slava 
Published: September 2024

In the late 1960s and 70s, due to the Soviet regime’s crackdown on dissident activities and rising anti-Semitic policies, many mathematicians from “undesirable” groups faced discrimination and serious administrative restrictions on work and study at top-ranking official institutions. To overcome such barriers, the mathematical community built extensive social networks around informal or semi-formal study groups and seminars, which formed a parallel social infrastructure for learning and research. As result, mathematical activity began shifting from public educational and research institutions into private or semi-private settings — family apartments, summer dachas, and countryside walks. For many Soviet mathematicians, instead of being a refuge from work, their home apartments and dachas became their primary working spaces — places where they did their research, met with students, and exchanged ideas with colleagues. At the intersection of work and private life, a tightly knit mathematical community emerged, whose commitment to scholarship went beyond formal duty or required curriculum, a community practicing mathematics as a “way of life.” The parallel social infrastructure functioned in tense interdependency with official institutions and borrowed some characteristics of the official system it opposed.
Parish Chronicle as a Source for Local History and Regional Church History of the Synodal Period (on the example of the chronicle of the fortress church of the apostles Peter and Paul in Petropavlovsk)
Authors: Березин М.А. 
Published: September 2024

Статья представляет собой расширенный текст доклада на III научно-практической конференции «Империя и Церковь», проходившей 14–15 апреля 2022 г. в Санкт-Петербургской духовной академии. Приходское летописание, введенное указом Святейшего Синода во второй половине XIX века, — один из важнейших документальных источников по региональной гражданской и церковной жизни конца XIX — начала XX вв. Анализируемая в статье летопись приходской крепостной церкви апостолов Петра и Павла г. Петропавловска — единственная из корпуса хронографических документов благочиния городских церквей Петропавловского округа, которая не была утеряна в послереволюционный период. На страницах документа отображаются исторические факты из жизни прихода периода 1848–1922 гг., перекликающиеся с событиями, имеющими общероссийское измерение: строительство железных дорог, стихийные бедствия, патриотическая деятельность жителей, учреждение викарной архиерейской кафедры, меценатство, начало советских антирелигиозных гонений, зарождение обновленческого раскола и проч. Статья написана на основании ранее не введенных в научный оборот документов, хранящихся в фондах Центрального государственного архива Республики Казахстан (г. Алматы).
The article is an extended text of the report at the III scientific-practical conference “Empire and the Church”, held on April 14–15, 2022 at the St. Petersburg Theological Academy. The parish chronicle, introduced by decree of the Holy Synod in the second half of the 19th century, is one of the most important documentary sources on regional civil and church life in the late 19th and early 20th centuries. The chronicle of the parish fortress church of the Apostles Peter and Paul in Petropavlovsk, analyzed in the article, is the only one from the corpus of chronographic documents of the deanery of the city churches of the Petropavlovsk District that was not lost in the post-revolutionary period. The pages of the document display historical facts from the life of the parish from 1848 to 1922, echoing events that have an all-Russian dimension: the construction of railways, natural disasters, the patriotic activity of residents, the establishment of a vicar bishop’s chair, patronage, the beginning of Soviet antireligious persecution, the emergence of a renovationist schism and other The article is based on documents not previously introduced into scientific circulation, stored in the funds of the Central State Archive of the Republic of Kazakhstan (Almaty).
“The Holy Fathers Forbid any Minister to Serve without the Command of his Bishop”: Outlines for Future Commentaries on the Canonical Answers of Metropolitan John II
Authors: Гайденко П.И. 
Published: September 2024

Среди множества канонических ответов, данных митрополитом Иоанном черноризцу Иакову, присутствует запрет клирикам служить без «повеления» своего (местного) епископа. При всей самоочевидной каноничности святительского требования вызывает вопрос о том, что послужило причиной для введения данной нормы. Скорее всего Канонические ответы отразили нестроения и проблемы, которые имели место в жизни Русской церкви, а точнее Киевской епископии (городского округа, непосредственно подчинённого митрополиту). Рассматриваемое требование митрополита, с одной стороны, очень точно соответствовало литургическим традициям Византии, с другой стороны, было призвано каким-то образом повлиять на бесконтрольное совершение служб. Среди причин, приводивших к такой специфической ситуации в области литургического служения, особого внимания заслуживает богослужебная практика этого времени, не предполагавшая использование антиминсов. Такая традиция существенно ограничивала влияние правящих архиереев на клириков своей области.
In the Canonical answers of Metropolitan John to monk Jacob there is a prohibition for clergy to serve without the “command” of their (local) bishop. While this requirement is completely canonically obvious, it is not entirely clear what the reason for including this norm in the Metropolitan’s answers was. The answers are most likely to have reflected the troubles and problems of the life of the Russian Church, or rather the Kyiv bishopric (an urban district directly subordinate to the metropolitan). The metropolitan’s demand in question, on the one hand, exactly corresponded to the liturgical traditions of Byzantium, while on the other hand, it was meant to somehow influence the uncontrolled performance of the services. Among the reasons leading to this, the liturgical practice of not using antimensions at that time deserves special attention. The absence of antimensions significantly limited the influence of the ruling bishops on the clergy of their regions.