bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of eye mask on sleep quality and pain in patients undergoing coronary artery bypass graft surgery: A double‐blind randomized controlled trial
Authors: Dagcan Sahin Necibe , Nal Burcu , Gurol Arslan Gulsah , Astarcioglu Mehmet Ali , Parlar Ali İhsan 
Published: September 2024

AbstractBackgroundPain is one of the common postoperative issues that impair recovery and quality of life in patients undergoing coronary artery bypass graft (CABG) surgery. It leads to prolonged recovery and sleep disturbances in patients.AimThis study was conducted to examine the effect of eye mask use on sleep quality and pain in patients undergoing CABG surgery.Study DesignA double‐blind randomized trial design was employed. The study included 60 patients undergoing CABG surgery. They were divided into intervention and control groups through block randomization. Data were collected using a ‘Demographic Characteristics Form’, the ‘Richards‐Campbell Sleep Questionnaire (RCSQ)’ and a ‘Visual Analogue Scale’ (VAS) through face‐to‐face interviews. While patients in the control group received standard care throughout the night, patients in the intervention group received standard care and used eye mask. All patients were followed up for three nights. The CONSORT was used to report the study.ResultsThe main outcome of the study, the RCSQ score, was higher in the intervention group at baseline. The intervention group had higher RCSQ scores than the control group at time 1 and time 2. There were no differences between the groups in the secondary outcome, pain levels. The control group had higher pain scores at time 1 and time 2 than the intervention group.ConclusionThe use of an eye mask after CABG surgery is an effective, safe and simple nursing intervention to improve sleep quality and control pain.Relevance to Clinical PracticeBecause the use of an eye mask is an independent and unique nursing intervention, nurses should be supported and allowed to practise it.
Oral squamous cell carcinoma identification by FTIR spectroscopy of oral biofluids
Authors: Lapa Teresa , Páscoa Ricardo N. M. J. , Coimbra Filipe , Medeiros Luís , Gomes Pedro S. 
Published: September 2024

AbstractObjectivesThis case study evaluated the efficacy of mid‐infrared spectroscopy on the identification of oral squamous cell carcinoma, following the assessment of unstimulated whole saliva.Study Design and MethodsThe trial follows a matched case–control design. Saliva samples were characterized through mid‐infrared spectroscopy, and chemometric tools were applied to distinguish between case and control participants, further identifying the spectral regions that played a pivotal role in the successful identification of oral squamous cell carcinoma.ResultsMid‐infrared spectroscopy was capable to discriminate between cancer patients and matched controls with 100% of correct predictions. Additionally, the spectral regions mostly contributing to the successful prediction were identified and found to be potentially associated with significant molecular changes crucial to the carcinogenic process.ConclusionThe application of mid‐infrared spectroscopy in saliva analysis may be regarded as an innovative, noninvasive, low cost, and sensitive technique contributing to the identification of oral squamous cell carcionma.
CAF‐secreted COL5A2 activates the PI3K/AKT pathway to mediate erlotinib resistance in head and neck squamous cell carcinoma
Authors: Guo Yibo , Chen Mingtao , Yang Jie , Zhou Wenkai , Feng Guanying , Wang Yang , Ji Tong , Zhang Yu , Liu Zheqi 
Published: September 2024

AbstractObjectiveTo investigate the mechanisms behind acquired resistance to erlotinib in head and neck squamous cell carcinoma (HNSCC) with a focus on the role of cancer‐associated fibroblasts (CAFs) and the PI3K/AKT signaling pathway.Materials and MethodsThis study analyzed gene expression profiles of erlotinib‐sensitive and ‐resistant HNSCC cell lines using datasets from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. It included microarray and RNA‐sequencing data, differentially expressed genes (DEGs) analysis, and pathway enrichment. In vitro experiments assessed the functional role of CAFs and the impact of the extracellular matrix component COL5A2 on erlotinib resistance.ResultsWe identified 124 DEGs associated with erlotinib resistance, with key genes like COL5A2 significantly upregulated. CAFs were found to highly express COL5A2, enhancing erlotinib resistance by activating the PI3K/AKT pathway. Higher erlotinib resistance scores correlated with increased infiltration of CAFs.ConclusionsErlotinib resistance in HNSCC is significantly influenced by the tumor microenvironment (TME), particularly through CAFs and the PI3K/AKT pathway. Targeting these mechanisms may offer new therapeutic strategies to overcome resistance in HNSCC patients.
Comparison of the effects of acupuncture methods on the temporomandibular disorder: A network meta‐analysis
Authors: Yan Qiuying , Bu He , Xu Guixing , Jia Min , Li Dehua 
Published: September 2024

AbstractObjectivesA network meta‐analysis (NMA) was applied to compare the therapeutic effect of different acupuncture methods on temporomandibular disorder (TMD).Materials and MethodsA computer retrieval was carried out in the English databases of Cochrane, PubMed, Embase and Web of Science, as well as the Chinese databases of CNKI, Wanfang and VIP for randomized controlled trials on the effect of acupuncture on TMD, with a retrieval deadline of January 21, 2024. Data analysis was conducted using R software and Bayesian method. The pain score served as the primary outcome measure, with the mouth opening as the secondary outcome measure.ResultsThirty‐five articles were included in the analysis, involving 1937 TMD patients. The NMA results suggested that DN‐PT had the best effect on relieving pain and improving mouth opening. (Description of all abbreviations in Supplementary Material S3).ConclusionsBased on the available evidence, the results of the NMA suggest that DN‐PT is most effective in relieving TMD pain and increasing mouth opening. However, due to the fact that some acupuncture therapies are only reported in a small number of research reports, this may lead to an increase in the randomness of the results and a decrease in the reliability.
OSR1 suppresses oral squamous cell carcinoma proliferation and migration via the AXIN2/β‐catenin pathway
Authors: Guo Xintong , Du Xinyi , Zhao Gaoye , Liu Chongshen , Gao Jing , Huang Zunzhi , Dong Wei 
Published: September 2024

AbstractObjectivesThe odd‐skipped related transcription factor 1 (OSR1) gene exerts distinct regulatory effects on tumorigenesis and development in various cancer types. However, the precise role of OSR1 in oral squamous cell carcinoma (OSCC) remains to be elucidated.MethodsGEPIA 2 and TCGA databases were utilized to analyze the OSR1 expression in head and neck squamous cell carcinoma (HNSC) patients and its impact on prognosis. Hematoxylin–eosin staining, immunohistochemistry, immunofluorescence, western blotting, and RT‐qPCR were employed to detect the OSR1 expression in OSCC tissues and cells. Lentivirus transfection was utilized for overexpression and downexpression of OSR1 in OSCC. CCK8 cell proliferation assay, colony formation and cell scratch assay were conducted to investigate the effects of OSR1 on biological behavior of OSCC cells. Western blotting and RT‐qPCR were applied to investigate the regulatory mechanism of OSR1 on AXIN2/β‐catenin signaling pathway.ResultsOSR1 expression was significantly decreased in HNSC patients, OSCC tissues and cells, leading to a decrease in 5‐year survival rate. OSR1 overexpression inhibited the proliferation and migration of OSCC cells, and the AXIN2/β‐catenin signaling pathway was inhibited. Silencing OSR1 had the opposite effect.ConclusionsOSR1 functioned as a tumor suppressor gene in OSCC proliferation and migration by regulating the AXIN2/β‐catenin signaling pathway.
Exploring the macroevolutionary impact of ecosystem engineers using an individual‐based eco‐evolutionary simulation
Authors: Smith Thomas J. , Parry Luke A. , Dunn Frances S. , Garwood Russell J. 
Published: September 2024

AbstractEcosystem engineers can radically reshape ecosystems by modulating the availability of resources to other organisms through modifying either physical or biological aspects of the environment. The introduction or removal of ecosystem engineers from otherwise stable ecosystems can impact the diversity of co‐occurring species, such as driving local extinctions of native taxa. While these impacts are well established over ecological timescales for a wealth of taxa, the macroevolutionary implications of the onset of ecosystem engineering behaviours are less clear. Despite this uncertainty, ecosystem engineering has been implicated in several major transitions in Earth history including the appearance of extensive bioturbation during the Cambrian substrate revolution and associated Ediacaran–Cambrian turnover, and the Great Oxygenation Event. Whether ecosystem engineers are frequently associated with turnover and extinction in deep time is not known. Here we investigate this with an eco‐evolutionary simulation framework in which we assign lineages the ability to impact the fitness of co‐occurring taxa through phenotype–environment feedback. We explore numerous conditions, including how frequently such feedback occurs, and whether ecosystem engineers modify or create niches. We show that there is no general expected outcome from the introduction of ecosystem engineers. In a minority of runs, ecosystem engineering lineages completely dominate, rendering all others extinct, but in others they persist (but do not dominate), or die out. We suggest that ecosystem engineers have complex impacts, but possess the capacity to profoundly shape diversity, and it is appropriate to consider them alongside other exogenous extinction drivers in deep time.
The Transcription Factor ZmMYB56 Regulates High CO2‐Induced Stomatal Closure in Maize Seedlings by Regulating ZmHLT1 Expression
Authors: Baozhu Li , Runan Liu , Hui Zhang , Jiong Liu , Yanan Tian , Pengtao Wang , Zuliang Li , Tingting Chen , Fuhang Jiao , Jiaxing Li , Tengfei Jia , Qingzeng Li , Yingxue Li , Xiangyu Zhang , Han Li , Zhao Xiang 
Published: September 2024

ABSTRACTStomata are channels through which plants exchange H2O and CO2 with the external environment. The regulation of stomatal movement has significant impacts on plant growth, development and stress adaptation. Here, we present a maize R2R3−MYB transcription factor, ZmMYB56, which regulates high CO2‐induced stomatal closure in maize seedlings. ZmMYB56 is highly expressed in stomatal guard cells and is negatively regulated by CO2 and HCO3−. Loss of ZmMYB56 function leads to insensitivity to high CO2. As a transcription factor, ZmMYB56 binds to a cis‐acting element in the ZmHLT1 promoter and regulates its expression. ZmHLT1 plays a key role in CO2‐ induced maize stomatal movement, and its absence causes a severe weakening of maize's response to ambient CO2. ZmHLT1 expression is negatively regulated by bicarbonate, which does not occur in Zmmyb56 mutants, highlighting the significance of this regulatory relationship in plant responses to CO2 and HCO3−. Taken together, these results show that ZmMYB56‐regulated ZmHLT1 expression is important for high CO2‐induced stomatal closure in maize. Our findings provide insight into genetic pathways that could be manipulated to improve maize growth and stress tolerance, especially under increasing atmospheric CO2 concentrations.
Development and psychometric properties of an instrument to evaluate missed nursing care in home care: A validation study
Authors: Di Nitto Marco , Zaghini Francesco , Caponnetto Valeria , Ferraiuolo Fabio , Napolitano Francesca , Alvaro Rosaria , Lancia Loreto , Manara Duilio Fiorenzo , Rasero Laura , Rocco Gennaro , Mazzoleni Beatrice , Sasso Loredana , Bagnasco Annamaria 
Published: September 2024

AbstractObjectiveTo develop and validate a questionnaire to evaluate missed nursing care (MNC) in a home care setting.DesignA new instrument was developed and tested performing a preliminary analysis of a multicenter cross‐sectional study in Italy. Reporting was performed according to COnsensus‐based Standards for the selection of health status Measurement INstruments (COSMIN) guidelines.SampleEight hundred out of a total of 2549 home care nurses enrolled in AIDOMUS‐IT were considered for the validation of the Missed Nursing Care in Home Care (MNC_HC).MeasurementsThe MNC_HC instrument was developed by a panel of experts and underwent content and face validation. Exploratory (EFA) and confirmatory factor analyses (CFA) were conducted.ResultsEFA revealed a one‐factor solution, explaining 56% of the total variance for MNC_HC. CFA confirmed excellent structural validity, with a one‐factor model showing an exceptional fit (χ2 (27) = 141.39, p < .001, RMSEA = 0.04, SRMR = 0.04, CFI = 0.99, TLI = 0.99, factor loadings > 0.5). MNC_HC also demonstrated high reliability (Cronbach's α = 0.92). The activity with the highest rate of missed care was the documentation of nursing care (77%), while activities related to nursing techniques (e.g., injections, dressings, etc.) were reported to be missed less (33.63%).ConclusionsMNC_HC is a quick‐filling, valid, reliable, and psychometrically sound instrument for measuring MNC in home care useful for future research.
Attention as selection for action defended
Authors: Wu Wayne 
Published: September 2024

AbstractAttention has become an important focal point of recent work in ethics and epistemology, yet philosophers continue to be noncommittal about what attention is. In this paper, I defend attention as selection for action in a weak form, namely that selection for action is sufficient for attention. I show that selection for action in this conception captures how we, the folk, experience it and how the cognitive scientist studies it. That is, selection for action pulls empirical and folk‐psychology together. Accordingly, philosophers who take seriously either source have reason to work with selection for action as their starting conception of attention. This conception provides a way to bridge empirical and philosophical concerns where attention is central. The theoretical advantages of selection for action have been obscured by the common opinion that it is easily refuted. I defend the position against many of the published objections and then deploy it to provide a foundation for the intuitive, but inchoate, idea of attention being gradable, something of which there can be more or less. An analysis of the gradability of attention is then applied to consider recent work on the harms due to a surplus of attention.
Justification, normalcy and randomness
Authors: Smith Martin 
Published: September 2024

AbstractSome random processes, like a series of coin flips, can produce outcomes that seem particularly remarkable or striking. This paper explores an epistemic puzzle that arises when thinking about these outcomes and asking what, if anything, we can justifiably believe about them. The puzzle has no obvious solution, and any theory of epistemic justification will need to contend with it sooner or later. The puzzle proves especially useful for bringing out the differences between three prominent theories; the probabilist theory, the normic theory and a theory recently defended by Goodman and Salow.
Understanding abortion legality and trimester of abortion care in Ohio, West Virginia and Kentucky, three abortion‐restrictive states
Authors: Beckmeyer Annamarie L. , Brenner‐Levoy Jeremy A. , Hill B. Jessie , Odum Tamika C. , Turner Abigail Norris , Norris Alison H. , Bessett Danielle , Rivlin Katherine L. 
Published: September 2024

AbstractIntroductionIn the era of Dobbs, legality of abortion care in the United States depends upon state law. Even before Dobbs, while abortion remained legal mounting restrictions and debate surrounding legal abortion could have led to confusion about abortion legality and discouraged patients from accessing legal abortion. We hypothesized an association between believing abortion is illegal or uncertainty about legality with later timing of abortion care.MethodsWe surveyed patients seeking abortion care in Ohio, West Virginia, and Kentucky from April 2020 to April 2021. We asked about their understanding of abortion legality at the time they were first deciding to have an abortion. Using unconditional logistic regression models, we examined associations between beliefs about abortion legality (measured as belief that abortion is legal or sometimes legal versus. illegal or unsure) and timing of abortion care (measured as trimester of abortion).ResultsOver half (57%) of the 1,479 patients who met eligibility criteria and completed the survey believed abortion was always legal, 21% thought abortion was sometimes legal, 12% believed abortion was illegal, and 10% did not know. Most (92%) had a first trimester abortion (<14 weeks gestation). Belief that abortion was illegal, or uncertainty about abortion legality, was not significantly associated with second trimester abortion care (unadjusted odds ratio [uOR]: 0.78, 95% confidence interval [CI]: 0.50–1.20). This association did not change meaningfully after adjusting for demographic and clinical variables (adjusted OR [aOR]: 0.83, 95% CI: 0.51–1.33).DiscussionMore than one in five patients presenting for abortion care in three abortion‐restrictive states prior to Dobbs erroneously believed that abortion was illegal or were unsure. Understanding of legality was not significantly associated with timing of abortion care. These misunderstandings could escalate under Dobbs.
Advancing Aquaculture Sustainability: A Comprehensive Review of Biofloc Technology Trends, Innovative Research Approaches, and Future Prospects
Authors: Liu Gang , Verdegem Marc , Ye Zhangying , Zhao Jian , Xiao Jinxing , Liu Xingguo , Liang Qinlang , Xiang Kun , Zhu Songming 
Published: September 2024

ABSTRACTBiofloc technology (BFT), initially adapted for shrimp farming in the 1970s, represents a sophisticated ecosystem of microorganisms designed to enhance aquaculture productivity and sustainability. Despite its established history, research into BFT is surprisingly still at an early stage globally. This review conducted a bibliometric analysis of 612 articles from major aquaculture journals spanning 2008–2023 to systematically explore the development, trends, and focal points of BFT research. The analysis revealed that the bulk of significant contributions originates from Brazil and China, and highlighting areas of interest can be categorized into four hotspots, such as (1) efficient nitrogen transformation, (2) biofloc microbiology, (3) biofloc's immunostimulant properties, and (4) the evaluation of research methodologies. At the end, the microecology concept was introduced, and the cross‐discipline methods were promoted in the aquaculture field. Notably, much of the BFT research is still at an exploratory phase, with numerous functional bacteria unidentified and optimization strategies for BFT underdeveloped. These gaps present opportunities for enhancing aquaculture through improvements in wastewater management, product quality, safety, and yield. Furthermore, the review notes a growing trend in applying microbiome research and microecological analysis in aquaculture, with high‐throughput sequencing data increasingly used to understand microbial interactions and nitrogen transformation within bioflocs. This direction promises to unlock further insights into the complex microbial ecosystems of bioflocs and their applications in sustainable aquaculture.
No signs of mast cell involvement in long‐COVID: A case–control study
Authors: Lenning Ole Bernt , Jonsson Grete , Grimstad Tore , Janssen Emiel A. M. , Braut Geir Sverre , Berven Frode , Omdal Roald 
Published: September 2024

AbstractLong‐COVID caused by SARS‐CoV‐2 infection has significant and increasing effects on human health worldwide. Although a unifying molecular or biological explanation is lacking, several pathophysiological mechanisms have been proposed. Involvement of mast cells—evolutionary old “multipurpose” innate immune cells—was reported recently in studies of acute infection and post‐acute‐COVID‐19 syndrome. Mast cell activity has been suggested in long‐COVID. In this case–control study, we compared data from 24 individuals with long‐COVID (according to the NICE criteria) and 24 age‐ and sex‐matched healthy individuals with a history of SARS‐CoV‐2 infection without developing sequelae. Serum levels of the proteases beta‐tryptase (TPSB2) and carboxypeptidase (CPA3), which are mast cell specific, were measured using immunoassays. The values were compared between the two groups and correlated to measures of physical exertional intolerance. TPSB2 and CPA3 levels were median (range) 26.9 (2.0–1000) and 5.8 (1.5–14.0) ng/mL, respectively, in the long‐COVID group. The corresponding values in the control group were 10.9 (2.0–1000) (p = 0.93) and 5.3 (3.5–12.9) ng/mL (p = 0.82). No significant correlations between TPSB2 or CPA3 levels and scores on the ten physical subscales of SF‐36, 3.1–3.10 were revealed. We found no significant differences in the levels of mast cell activation markers TPSB2 and CPA3 between the long‐COVID and control groups and no correlations with proxy markers of exercise intolerance. Mast cell activation does not appear to be part of long‐term pathogenesis of long‐COVID, at least in the majority of patients.
On the experience of goals: Differentiating goal‐generic value from goal‐specific value
Authors: Converse Benjamin A. , Roberts Annabelle R. , Hennecke Marie , Fishbach Ayelet 
Published: September 2024

AbstractWe distinguish between goal‐specific value, which refers to the intrinsic and extrinsic benefits associated with a particular goal (“value derived from the goal”), and goal‐generic value, which refers to the benefits associated with having, pursuing, or completing a goal in general (“value derived from a goal”). Motivation theory and research have traditionally, if tacitly, sought to explain decision‐making (e.g., What to prioritize? How much to invest?) based on goal‐specific value. But several goal‐related decision regularities are not easily explained by accounting for goal‐specific value alone, such as online workers choosing a lower‐paying assignment (over a higher‐paying assignment) if it allows them to complete the last step in a sequence and college students electing to do more work sooner (rather than less work later) if it provides them closure. Accounting for goal‐generic value—such as the positive experiences of purpose, progress, closure, and accomplishment—offers additional insight into people's decisions. More generally, auditing goals in a way that accounts for both goal‐specific value and goal‐generic value is crucial for understanding goal pursuits.