bluuebunny/crossref_metadata_2025_split huggingface dataset:
Concussion-Like Symptoms in Child and Youth Athletes at Baseline: What Is “Typical”?
Authors: Hunt Anne Williams , Paniccia Melissa , Reed Nick , Keightley Michelle 
Published: November 2016

Context: After a concussion, guidelines emphasize that an athlete should be asymptomatic before starting a return-to-play protocol. However, many concussion symptoms are nonspecific and may be present in individuals without concussion. Limited evidence exists regarding the presence of “typical” or preinjury (baseline) symptoms in child and youth athletes.
Objective: To describe the frequency of symptoms reported at baseline by child and youth athletes and identify how age, sex, history of concussion, and learning factors influence the presence of baseline symptoms.
Design: Cross-sectional cohort study.
Setting: Baseline testing was conducted at a hospital research laboratory or in a sport or school setting (eg, gym or arena).
Patients or Other Participants: A total of 888 child (9−12 years old, n = 333) and youth (13−17 years old, n = 555) athletes participated (46.4% boys and 53.6% girls, average age = 13.09 ± 1.83 years).
Main Outcome Measure(s): Demographic and symptom data were collected as part of a baseline protocol. Age-appropriate versions of the Post-Concussion Symptom Inventory (a self-report concussion-symptoms measure with strong psychometric properties for pediatric populations) were administered. Demographic data (age, sex, concussion history, learning factors) were also collected.
Results: Common baseline symptoms for children were feeling sleepier than usual (30% boys, 24% girls) and feeling nervous or worried (17% boys, 25% girls). Fatigue was reported by more than half of the youth group (50% boys, 67% girls). Nervousness was reported by 32% of youth girls. Headaches, drowsiness, and difficulty concentrating were each reported by 25% of youth boys and girls. For youths, a higher total symptom score was associated with increasing age and number of previous concussions, although these effects were small (age rs = 0.143, number of concussions rs = .084). No significant relationships were found in the child group.
Conclusions: Children and youths commonly experienced symptoms at baseline, including fatigue and nervousness. Whether clinicians should expect complete symptom resolution after concussion is not clear.
Support Received During the Transition to Practice for the Secondary School Graduate-Assistant Athletic Trainer
Authors: Mazerolle Stephanie M. , Walker Stacy E. , Kirby Jessica L. 
Published: November 2016

Context: Transitioning into clinical practice can be stressful for the newly credentialed athletic trainer (AT). The support provided by mentors, peers, and athletic training faculty can increase confidence and enhance the transition. To create specific initiatives for a smoother transition, the perspectives of those in the secondary school setting are needed.
Objective: To examine the transition to practice and mentorship of newly credentialed ATs providing medical care in the secondary school setting.
Design: Qualitative study.
Setting: Secondary school setting.
Patients or Other Participants: A total of 14 ATs (2 men, 12 women; age = 23.0 ± 2.0 years) participated in our study. They were employed in the secondary school setting through graduate assistantships, had been credentialed for less than 1 year, and had completed professional bachelor's degree programs.
Data Collection and Analysis: We completed 14 semistructured phone interviews. Interviews were recorded and transcribed verbatim. Two researchers independently following the stepwise progression of a general inductive approach completed the data analysis. Trustworthiness was established through multiple-analyst triangulation, peer review, and member checks.
Results: Two major themes emerged regarding the support received by our participants: past mentors and current networks of professionals. Past mentors provided autonomous learning opportunities during clinical education and then served as resources for guidance and advice. Current networks of professionals were defined by 2 subthemes: professional medical care providers and non–medical care providers within the secondary school setting (ie, athletic directors, coaches, parents).
Conclusions: Former preceptors and faculty provided resources and support to help develop the newly credentialed AT's confidence and facilitate the transition. Preceptors should allow increased independence to help their students develop as clinicians. The creation of networks within the community, that is, the secondary school itself, is also critical in the transition as it provides the AT with role legitimation.
Patient Experiences of Recovery After Autologous Chondrocyte Implantation: A Qualitative Study
Authors: Toonstra Jenny L. , Howell Dana , English Robert A. , Lattermann Christian , Mattacola Carl G. 
Published: November 2016

Context:
The recovery process after autologous chondrocyte implantation (ACI) can be challenging for patients and clinicians alike due to significant functional limitations and a lengthy healing time. Understanding patients' experiences during the recovery process may assist clinicians in providing more individualized care.

Objective:
To explore and describe patients' experiences during the recovery process after ACI.

Design:
Qualitative study.

Setting:
Orthopaedic clinic.

Patients or Other Participants:
Participants from a single orthopaedic practice who had undergone ACI within the previous 12 months were purposefully selected.

Data Collection and Analysis:
Volunteers participated in 1-on-1 semistructured interviews to describe their recovery experiences after ACI. Data were analyzed using the process of horizontalization.

Results:
Seven patients (2 men, 5 women; age = 40.7 ± 7.5 years, time from surgery = 8.7 ± 4.2 months) participated. Four themes and 6 subthemes emerged from the data and suggested that the recovery process is a lengthy and emotional experience. Therapy provides optimism for the future but requires a collaborative effort among the patient, surgeon, rehabilitation provider, and patient's caregiver(s). Furthermore, patients expressed frustration that their expectations for recovery did not match the reality of the process, including greater dependence on caregivers than expected.

Conclusions:
Patients' expectations should be elicited before surgery and managed throughout the recovery process. Providing preoperative patient and caregiver education and encouraging preoperative rehabilitation can assist in managing expectations. Establishing realistic goals and expectations may improve rehabilitation adherence, encourage optimism for recovery, and improve outcomes in the long term.
Cervical Injury Assessments for Concussion Evaluation: A Review
Authors: Cheever Kelly , Kawata Keisuke , Tierney Ryan , Galgon Anne 
Published: November 2016

Background:
A concussion is a complex pathophysiologic process that is induced by biomechanical forces and affects the brain. Cervical injuries and concussion can share similar mechanisms and nearly identical symptoms or causes. Therefore, symptoms or causes alone may be insufficient to differentiate between patients with a concussion and patients with cervical injuries.

Objective:
To demonstrate the homogeneous causes and symptoms observed in patients with a concussion and patients with cervical injury and to provide information on clinical tests that can differentiate cervical injury from pathologic conditions of vestibular or central origin.

Summary:
Given that concussion and cervical injury share similar causes and symptoms, this information alone may be insufficient to diagnose a concussion. Clinical assessments, such as the cervical joint-reposition error test, smooth-pursuit neck-torsion test, head-neck differentiation test, cervical flexion-rotation test, and physical examination of the cervical spine, can be performed after a head and neck pathomechanical event to identify the presence of cervical injury. Differentiating between a concussion and cervical injury is clinically vital for timely and appropriate evidence-based treatment.

Conclusions:
Specific clinical tests should be used after a head and neck pathomechanical event to differentiate between symptoms due to a concussion and cervical injury. Continued research on the clinical utility of the 5 identified cervicogenic tests is also recommended.
Assay for identification of heterozygous single-nucleotide polymorphism (Ala67Thr) in human poliovirus receptor gene
Authors: Nandi Shyam Sundar , Sharma Deepa Kailash , Deshpande Jagadish M. 
Published: November 2016

Background & objectives:
It is important to understand the role of cell surface receptors in susceptibility to infectious diseases. CD155 a member of the immunoglobulin super family, serves as the poliovirus receptor (PVR). Heterozygous (Ala67Thr) polymorphism in CD155 has been suggested as a risk factor for paralytic outcome of poliovirus infection. The present study pertains to the development of a screening test to detect the single nucleotide (SNP) polymorphism in the CD155 gene.

Methods:
New primers were designed for PCR, sequencing and SNP analysis of Exon2 of CD155 gene. DNAs extracted from either whole blood (n=75) or cells from oral cavity (n=75) were used for standardization and validation of the SNP assay. DNA sequencing was used as the gold standard method.

Results:
A new SNP assay for detection of heterozygous Ala67Thr genotype was developed and validated by testing 150 DNA samples. Heterozygous CD155 was detected in 27.33 per cent (41/150) of DNA samples tested by both SNP detection assay and sequencing.

Interpretation & conclusions:
The SNP detection assay was successfully developed for identification of Ala67Thr polymorphism in human PVR/CD155 gene. The SNP assay will be useful for large scale screening of DNA samples.
Distribution trends & antibiogram pattern of Salmonella enterica serovar Newport in India
Authors: Kumar Y. , Gupta N. , Vaish V.B. , Gupta S. 
Published: November 2016

Background & objectives:
Salmonellosis is a major public health concern worldwide. Besides typhoidal salmonellae, infections due to non-typhoidal serovars of Salmonella are also associated with high morbidity and mortality leading to huge economic losses. Among non-typhoidal serovars, Salmonella Newport has been reported as a major cause of foodborne infections resulting in outbreaks due to consumption of contaminated food items. Little data related to this serovar are available from India leading to the scarcity of information on the distribution trends of this important serovar in the country. Therefore, an effort was made in the present study to generate data on distribution trends and antibiogram of S. Newport in the country.

Methods:

S. Newport isolates received at the National Salmonella and Escherichia Centre at Kasauli, India, during January 2010 to December 2013 were analysed for their distribution trends and antibiogram data were also generated using standard methods.

Results:
In the present study, S. Newport isolates were received from eight States and one union territory of the country and highest proportion of S. Newport isolates were found to be from humans (53.61%) followed by animals (27.84%) and food (18.56%). S. Newport isolates exhibited resistance to all drugs used in the present study except chloramphenicol, ciprofloxacin and cefuroxime.

Interpretation & conclusions:
Considering distribution of this important serovar of Salmonalla and its wide range of reservoirs, steps towards formulation and execution of efficient surveillance programmes should be taken.
Observed microphysical changes in Arctic mixed-phase clouds when transitioning from sea ice to open ocean
Authors: Young Gillian , Jones Hazel M. , Choularton Thomas W. , Crosier Jonathan , Bower Keith N. , Gallagher Martin W. , Davies Rhiannon S. , Renfrew Ian A. , Elvidge Andrew D. , Darbyshire Eoghan , Marenco Franco , Brown Philip R. A. , Ricketts Hugo M. A. , Connolly Paul J. , Lloyd Gary , Williams Paul I. , Allan James D. , Taylor Jonathan W. , Liu Dantong , Flynn Michael J. 
Published: November 2016

Abstract. In situ airborne observations of cloud microphysics, aerosol properties, and thermodynamic structure over the transition from sea ice to ocean are presented from the Aerosol-Cloud Coupling And Climate Interactions in the Arctic (ACCACIA) campaign. A case study from 23 March 2013 provides a unique view of the cloud microphysical changes over this transition under cold-air outbreak conditions. Cloud base lifted and cloud depth increased over the transition from sea ice to ocean. Mean droplet number concentrations, Ndrop, also increased from 110 ± 36 cm−3 over the sea ice to 145 ± 54 cm−3 over the marginal ice zone (MIZ). Downstream over the ocean, Ndrop decreased to 63 ± 30 cm−3. This reduction was attributed to enhanced collision-coalescence of droplets within the deep ocean cloud layer. The liquid water content increased almost four fold over the transition and this, in conjunction with the deeper cloud layer, allowed rimed snowflakes to develop and precipitate out of cloud base downstream over the ocean. The ice properties of the cloud remained approximately constant over the transition. Observed ice crystal number concentrations averaged approximately 0.5–1.5 L−1, suggesting only primary ice nucleation was active; however, there was evidence of crystal fragmentation at cloud base over the ocean. Little variation in aerosol particle number concentrations was observed between the different surface conditions; however, some variability with altitude was observed, with notably greater concentrations measured at higher altitudes ( >  800 m) over the sea ice. Near-surface boundary layer temperatures increased by 13 °C from sea ice to ocean, with corresponding increases in surface heat fluxes and turbulent kinetic energy. These significant thermodynamic changes were concluded to be the primary driver of the microphysical evolution of the cloud. This study represents the first investigation, using in situ airborne observations, of cloud microphysical changes with changing sea ice cover and addresses the question of how the microphysics of Arctic stratiform clouds may change as the region warms and sea ice extent reduces.
El Niño, La Niña, and the global sea level budget
Authors: Piecuch Christopher G. , Quinn Katherine J. 
Published: November 2016

Abstract. Previous studies show that nonseasonal variations in global-mean sea level (GMSL) are significantly correlated with El Niño–Southern Oscillation (ENSO). However, it has remained unclear to what extent these ENSO-related GMSL fluctuations correspond to steric (i.e., density) or barystatic (mass) effects. Here we diagnose the GMSL budget for ENSO events observationally using data from profiling floats, satellite gravimetry, and radar altimetry during 2005–2015. Steric and barystatic effects make comparable contributions to the GMSL budget during ENSO, in contrast to previous interpretations based largely on hydrological models, which emphasize the barystatic component. The steric contributions reflect changes in global ocean heat content, centered on the Pacific. Distributions of ocean heat storage in the Pacific arise from a mix of diabatic and adiabatic effects. Results have implications for understanding the surface warming slowdown and demonstrate the usefulness of the Global Ocean Observing System for constraining Earth's hydrological cycle and radiation imbalance.
Temporal evolution of crack propagation propensity in snow in relation to slab and weak layer properties
Authors: Schweizer Jürg , Reuter Benjamin , van Herwijnen Alec , Richter Bettina , Gaume Johan 
Published: November 2016

Abstract. If a weak snow layer below a cohesive slab is present in the snow cover, unstable snow conditions can prevail for days or even weeks. We monitored the temporal evolution of a weak layer of faceted crystals as well as the overlaying slab layers at the location of an automatic weather station in the Steintälli field site above Davos (Eastern Swiss Alps). We focussed on the crack propagation propensity and performed propagation saw tests (PSTs) on 7 sampling days during a 2-month period from early January to early March 2015. Based on video images taken during the tests we determined the mechanical properties of the slab and the weak layer and compared them to the results derived from concurrently performed measurements of penetration resistance using the snow micro-penetrometer (SMP). The critical cut length, observed in PSTs, increased overall during the measurement period. The increase was not steady and the lowest values of critical cut length were observed around the middle of the measurement period. The relevant mechanical properties, the slab effective elastic modulus and the weak layer specific fracture, overall increased as well. However, the changes with time differed, suggesting that the critical cut length cannot be assessed by simply monitoring a single mechanical property such as slab load, slab modulus or weak layer specific fracture energy. Instead, crack propagation propensity is the result of a complex interplay between the mechanical properties of the slab and the weak layer. We then compared our field observations to newly developed metrics of snow instability related to either failure initiation or crack propagation propensity. The metrics were either derived from the SMP signal or calculated from simulated snow stratigraphy (SNOWPACK). They partially reproduced the observed temporal evolution of critical cut length and instability test scores. Whereas our unique dataset of quantitative measures of snow instability provides new insights into the complex slab-weak layer interaction, it also showed some deficiencies of the modelled metrics of instability – calling for an improved representation of the mechanical properties.
Relation of anthropometric measurements to ocular biometric changes and refractive error in children with thalassemia
Authors: Elkitkat Rania S. , El-Shazly Amany A. , Ebeid Weam M. , Deghedy Marwa R. 
Published: November 2016

Purpose: To evaluate and correlate anthropometric, biometric, and refractive error changes in thalassemia major (TM). Methods: One hundred children with TM and another hundred healthy controls were recruited. Height, weight, body mass index (BMI), and occipitofrontal circumference (OFC) were the anthropometric parameters recorded. Full ophthalmologic examination was performed, including best-corrected visual acuity, cycloplegic refraction, slit-lamp examination, Goldmann applanation tonometry, indirect ophthalmoscopy, keratometry (K readings), and ocular biometry. Results: Compared to controls, children with TM were shorter and lighter, with a smaller BMI (p<0.001); however, no significant difference existed in OFC. Regarding ocular biometric data, patients with thalassemia had steeper mean K readings (p = 0.03), shorter axial length (AXL) (p = 0.005), shorter vitreous chamber depth (p<0.001), and thicker crystalline lens (p<0.001) than controls. Patients with thalassemia had a significant myopic shift (p = 0.003). Multiple regression analyses only showed a significant correlation between corneal astigmatism and both weight and height (β = -0.05 and p = 0.03 and β = 0.06 and p = 0.04, respectively). Spherical equivalent was significantly correlated to K readings, lens thickness, and anterior chamber depth (p<0.0001 for all parameters). Conclusions: Compared to controls, children with TM have significant retardation in general and ocular growth (smaller BMI and shorter AXL). Ocular growth changes probably resulted in compensatory biometric changes (steeper corneas and thicker lenses) to reach emmetropization, with an exaggerated response and subsequent myopic shift. However, growth retardation is not directly related to ocular growth changes, myopic shift, or variations in biometric parameters.
Variables Affecting Evaluation and Publication of Oncology Case Reports: A Systematic Analysis
Authors: Florita Antonio , Morittu Elena , Galeone Carlotta , Leon Antonette E. , Ballarini Rossella , Zuanetti Giulio 
Published: November 2016

Background Studies on factors affecting editorial decisions of scientific journals are scarce. In this study, we focused on case reports submitted to oncology journals and analyzed whether their nature or other relevant variables affected the chances of their acceptance. Methods We analyzed case reports submitted to 2 oncology journals: Tumori Journal and The International Journal of Biological Markers, and split them into 3 predefined groups: those (a) describing rare or unusual presentation of diseases, (b) describing the side effects of an intervention or (c) describing the success of a novel intervention. Publication status was retrospectively retrieved from the submission system, and acceptance rates were calculated taking into account other variables including geographic location of corresponding author. Results A total of 326 case reports were suitable for analysis. The acceptance rate was 35.4% for group (a), 27.9% for group (b), 19.6% for group (c) (p = 0.01). After correcting for other variables, the odds ratio (OR) of being accepted for group (c) was 0.58 (95% CI, 0.33-1.00) compared with the other groups combined. There was a highly significant difference of acceptance rates between manuscripts with authors coming from developed vs. developing countries that remained significant (OR = 5.94; 95% CI, 3.05-10.09) after correcting for multiple variables. Conclusions The nature of a case report in oncology may affect acceptance rate, with case reports describing successful approaches or side effects of treatment being accepted with a higher frequency then case reports describing a rare clinical or diagnostic scenario. Also, works coming from developed countries are accepted significantly more frequently than case reports coming from developing countries.
The isolation and characterization of systemic sclerosis vascular smooth muscle cells: enhanced proliferation and apoptosis resistance
Authors: Altorok Nezam , Nada Shadia , Kahaleh Bashar 
Published: November 2016

Background Vascular dysfunction is a major pathologic component of systemic sclerosis (SSc). The role of vascular smooth muscle cells (vSMCs) in the development of vascular dysfunction is still unknown. In this study, we describe a method for isolation of dermal vSMCs from skin biopsies, and we outline their functional phenotype. Methods We obtained 4 mm punch-skin biopsies from three SSc patients and matched controls. After trypsin digestion, cells were cultured for 14 days. vSMCs were isolated by first depleting CD31+ cells (endothelial cells), followed by positive selection of CD146+ cells. The CD31- CD146+ cells were then cultured in media optimized for SMCs proliferation. We evaluated cell proliferation, viability and apoptosis in normal and in low serum culture conditions. Cytoplasmic and nuclear expression levels of β-catenin were also investigated. Results The CD31- CD146+ cell population expressed smooth muscle MYH11, Desmin and Vimentin but did not express NG2. Flow cytometry confirmed the high purity of CD31- CD146+ MYHC11+ cell population that was maintained for up to the eleventh passage. SSc-vSMCs exhibited increased cell proliferation and viability compared to control cells. Under serum starvation conditions, SSc-vSMCs exhibited more proliferative capacity, and resistance to apoptosis compared to control-vSMCs. Furthermore, a cytoplasmic to nuclear translocation of β-catenin was seen in SSc-vSMCs but not in control-vSMCs. Conclusions This is the first report of successful isolation and initial characterization of SSc-vSMCs. It is likely that increased proliferation of SSc-vSMCs in association with resistance to apoptosis can adversely impact the vascular lesion in SSc.