bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peptide‐Based Molecular Hydrogels as Supramolecular Protein Mimics
Authors: Singh Nishant , Kumar Mohit , Miravet Juan F. , Ulijn Rein V. , Escuder Beatriu 
Published: August 2016

AbstractThis Minireview concerns recent advances in the design, synthesis, and application of low molecular‐weight peptidic hydrogelators. The sequence‐specific combinations of amino acid side chain functionalities combined with hydrogen bonding of amide backbones and hydrophobic (aromatic) capping groups give these peptidic molecules the intrinsic tendency to self‐assemble. The most prevalent designs include N‐capped amino acid residues, bolamphiphilic peptides, and amphipathic peptides. Factors such as hydrophobic effects, the Hofmeister effect, and tunable ionization influence their aggregation properties. The self‐assembly of simple bio‐inspired building blocks into higher organized structures allows comparisons to be drawn with proteins and their complex functionalities, providing preliminary insights into complex biological functions and also enabling their application in a wide range of fields including catalysis, biomedical applications, and mimicry of natural dissipative systems. The Minireview is concluded by a short summary and outlook, highlighting the advances and steps required to bridge the gaps in the understanding of such systems.
Fluorescence‐Tuned Polyhedral Oligomeric Silsesquioxane‐Based Porous Polymers
Authors: Wang Dengxu , Feng Shengyu , Liu Hongzhi 
Published: August 2016

AbstractTwo series of new polyhedral oligomeric silsesquioxane (POSS)‐based fluorescent hybrid porous polymers, HPP‐1 and HPP‐2, have been prepared by the Heck reaction of octavinylsilsesquioxane with 2,2′,7,7′‐tetrabromo‐9,9′‐spirobifluorene and 1,3,6,8‐tetrabromopyrene, respectively. Three sets of reaction conditions were employed to assess their effect on fluorescence. These materials exhibit tunable fluorescence from nearly no fluorescence to bright fluorescence both in the solid state and dispersed in ethanol under UV light irradiation by simply altering the reaction conditions. We speculated that the difference may be attributable to the fluorescence quenching induced by Et3N, P(o‐CH3Ph)3, and their hydrogen bromide salts employed in the reactions. This finding could give valuable suggestions for the construction of porous polymers with tunable/controllable fluorescence, especially those prepared by Heck and Sonogashira reactions in which these quenchers are used as organic bases or co‐catalysts. In addition, the porosities can also be tuned, but different trends in porosity have been found in these two series of polymers, which suggests that various factors should be carefully considered in the preparation of porous polymers with tunable/controllable porosity. Furthermore, HPP‐1 c showed moderate CO2 uptake and fluorescence that was efficiently quenched by nitroaromatic explosives, thereby indicating that these materials could be utilized as solid absorbents for the capture and storage of CO2 and as sensing agents for the detection of explosives.
Chiral HPLC Separation and Modeling of Four Stereomers of DL‐Leucine‐DL‐Tryptophan Dipeptide on Amylose Chiral Column
Authors: Alajmi Mohammed F. , Hussain Afzal , Suhail Mohd. , Mukhtar Sofi Danish , Sahoo Dibya Ranjan , Asnin Leonid , Ali Imran 
Published: August 2016

AbstractChiral high‐performance liquid chromatography (HPLC) separation and modeling of four stereomers of DL‐leucine‐tryptophan DL‐dipeptide on AmyCoat‐RP column are described. The mobile phase applied was ammonium acetate (10 mM)‐methanol‐acetonitrile (50:5:45, v/v). The flow rate of the mobile phases was 0.8 mL/min with UV detection at 230 nm. The values of retention factors for LL‐, DD‐, DL‐, and LD‐ stereomers were 2.25, 3.60, 5.00, and 6.50, respectively. The values of separation and resolution factors were 1.60, 1.39, and 1.30 and 7.76, 8.05, and 7.19. The limits of detection and quantitation were ranging from 1.0–2.3 and 5.6–14.0 μg/mL. The simulation studies established the elution orders and the mechanism of chiral recognition. It was seen that π–π connections and hydrogen bondings were the main forces for enantiomeric resolution. The reported chiral HPLC method may be applied for the enantiomeric separation of DL‐leucine‐DL‐tryptophan in unknown matrices.Chirality 28:642–648, 2016. © 2016 Wiley Periodicals, Inc.
The influence of personal and social identity on the clothing consumption of adolescents
Authors: Badaoui Khafid , Lebrun Anne‐Marie , Su Che‐Jen , Bouchet Patrick 
Published: August 2016

AbstractWe consider the influence of personal and social identity among adolescents on the importance they attach to clothing products and brands. The conceptual framework includes more conventional variables such as socialization (family, peers, media, and celebrities) and individual characteristics (gender and grade level). Based on a sample of 1,596 French high school adolescents, our results highlight: (i) the influence of identity on the importance attached to product and brand; (ii) the mediating effects of personal and social identities; and (iii) the moderating effects of gender and grade level. We conclude with an analysis of theoretical contributions, practical implications, and future research directions. Copyright © 2016 ASAC. Published by John Wiley & Sons, Ltd.
Oxidative desulphurization of model fuel by in situ produced hydrogen peroxide on palladium/active carbon
Authors: Wang Qing , Wang Shengqiang , Yu Hongbing 
Published: August 2016

AbstractThiophenic compounds are considered one of the major obstacles in deep desulphurization of transportation gasoil. In this paper, a single‐stage reactor, in which the induction of hydrogen peroxide, oxidation of thiophenes, and adsorption of sulphones from model fuel was demonstrated in one single step at mild temperatures. In our proposed mechanism, the removal of thiophenes from model fuel undergoes three stages: 2‐propanol dehydrogenation and in situ generation of hydrogen peroxide, oxidative desulphurization, and the adsorption of sulphones on active carbon. Palladium/active carbon (Pd/C) was not only used to catalyze the production of hydrogen peroxide, but also guarantees efficiency in the adsorption of sulphones from the oil phase and aqueous phase owing to its large specific surface area and pore volume. Thus, the goal to get ultra‐low sulphur fuel was well achieved under optimal conditions after almost all the sulphones had entered into the pores of active carbon and stayed in the adsorbent. Accumulation of sulphur in active carbon inhibits further desulphurization operation. Washing with excessive anhydrous ethanol, the efficiency of Pd/C was almost fully recovered.
2‐Amino[1,2,4]triazolo[1,5‐c]quinazolines and Derived Novel Heterocycles: Syntheses and Structure–Activity Relationships of Potent Adenosine Receptor Antagonists
Authors: Burbiel Joachim C. , Ghattas Wadih , Küppers Petra , Köse Meryem , Lacher Svenja , Herzner Anna‐Maria , Kombu Rajan Subramanian , Akkinepally Raghuram Rao , Hockemeyer Jörg , Müller Christa E. 
Published: August 2016

Abstract2‐Amino[1,2,4]triazolo[1,5‐c]quinazolines were identified as potent adenosine receptor (AR) antagonists. Synthetic strategies were devised to gain access to a broad range of derivatives including novel polyheterocyclic compounds. Potent and selective A3AR antagonists were discovered, including 3,5‐diphenyl[1,2,4]triazolo[4,3‐c]quinazoline (17, Ki human A3AR 1.16 nm) and 5′‐phenyl‐1,2‐dihydro‐3′H‐spiro[indole‐3,2′‐[1,2,4]triazolo[1,5‐c]quinazolin]‐2‐one (20, Ki human A3AR 6.94 nm). In addition, multitarget antagonists were obtained, such as the dual A1/A3 antagonist 2,5‐diphenyl[1,2,4]triazolo[1,5‐c]quinazoline (13 b, Ki human A1AR 51.6 nm, human A3AR 11.1 nm), and the balanced pan‐AR antagonists 5‐(2‐thienyl)[1,2,4]triazolo[1,5‐c]quinazolin‐2‐amine (11 c, Ki human A1AR 131 nm, A2AAR 32.7 nm, A2BAR 150 nm, A3AR 47.5 nm) and 9‐bromo‐5‐phenyl[1,2,4]triazolo[1,5‐c]quinazolin‐2‐amine (11 q, Ki human A1AR 67.7 nm, A2AAR 13.6 nm, A2BAR 75.0 nm, A3AR 703 nm). In many cases, significantly different affinities for human and rat receptors were observed, which emphasizes the need for caution in extrapolating conclusions between different species.
Clinical outcomes in metastatic uveal melanoma treated with PD‐1 and PD‐L1 antibodies
Authors: Algazi Alain P. , Tsai Katy K. , Shoushtari Alexander N. , Munhoz Rodrigo R. , Eroglu Zeynep , Piulats Josep M. , Ott Patrick A. , Johnson Douglas B. , Hwang Jimmy , Daud Adil I. , Sosman Jeffrey A. , Carvajal Richard D. , Chmielowski Bartosz , Postow Michael A. , Weber Jeffrey S. , Sullivan Ryan J. 
Published: August 2016

BACKGROUNDAntibodies inhibiting the programmed death receptor 1 (PD‐1) have demonstrated significant activity in the treatment of advanced cutaneous melanoma. The efficacy and safety of PD‐1 blockade in patients with uveal melanoma has not been well characterized.METHODSFifty‐eight patients with stage IV uveal melanoma received PD‐1 or PD‐1 ligand (PD‐L1) antibodies between 2009 and 2015 at 9 academic centers. Patients who were evaluable for response were eligible for the analysis. Imaging was performed every 12 weeks and at the investigators' discretion. Safety and clinical efficacy outcomes, including the best overall response, progression‐free survival (PFS), and overall survival (OS), were retrospectively determined.RESULTSOf 56 eligible patients, 48 (86%) had received prior therapy, and 35 (63%) had received treatment with ipilimumab. Three patients had an objective response to ipilimumab, and 8 had stable disease as their best response. Thirty‐eight patients (68%) received pembrolizumab, 16 (29%) received nivolumab, and 2 (4%) received atezolizumab. Objective tumor responses were observed in 2 patients for an overall response rate of 3.6% (95% confidence interval [CI], 1.8%‐22.5%). Stable disease (≥6 months) was observed in 5 patients (9%). The median PFS was 2.6 months (95% CI, 2.4‐2.8 months), and the median OS was 7.6 months (95% CI, 0.7‐14.6 months). There was no association between prior treatment with ipilimumab or liver‐directed therapy and PFS or OS. Treatment was well tolerated, and only 1 patient discontinued treatment because of toxicity.CONCLUSIONSPD‐1 and PD‐L1 antibodies rarely confer durable remissions in patients with metastatic uveal melanoma. Clinical trial enrollment should be prioritized in this population. Cancer 2016;122:3344–3353. © 2016 American Cancer Society.
The efficacy of anti‐PD‐1 agents in acral and mucosal melanoma
Authors: Shoushtari Alexander N. , Munhoz Rodrigo R. , Kuk Deborah , Ott Patrick A. , Johnson Douglas B. , Tsai Katy K. , Rapisuwon Suthee , Eroglu Zeynep , Sullivan Ryan J. , Luke Jason J. , Gangadhar Tara C. , Salama April K. S. , Clark Varina , Burias Clare , Puzanov Igor , Atkins Michael B. , Algazi Alain P. , Ribas Antoni , Wolchok Jedd D. , Postow Michael A. 
Published: August 2016

BACKGROUNDTherapeutic antibodies against programmed cell death receptor 1 (PD‐1) are considered front‐line therapy in metastatic melanoma. The efficacy of PD‐1 blockade for patients with biologically distinct melanomas arising from acral and mucosal surfaces has not been well described.METHODSA multi‐institutional, retrospective cohort analysis identified adults with advanced acral and mucosal melanoma who received treatment with nivolumab or pembrolizumab as standard clinical practice through expanded access programs or published prospective trials. Objective responses were determined using investigator‐assessed Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1. Progression‐free survival and overall survival were assessed using the Kaplan‐Meier method.RESULTSSixty individuals were identified, including 25 (42%) with acral melanoma and 35 (58%) with mucosal melanoma. Fifty‐one patients (85%) had received previous therapy, including 77% who had previously received ipilimumab. Forty patients (67%) received pembrolizumab at a dose of 2 mg/kg or 10 mg/kg, and 20 (33%) received nivolumab at a doses ranging from 0.3 to 10 mg/kg every 2 to 3 weeks. The objective response rate was 32% (95% confidence interval, 15%‐54%) in patients with acral melanoma and 23% (95% confidence interval, 10%‐40%) in those with mucosal melanoma. After a median follow‐up of 20 months in the acral melanoma group and 10.6 months in the mucosal melanoma group, the median progression‐free survival was 4.1 months and 3.9 months, respectively. Only 2 patients (3%) discontinued treatment because of toxicity.CONCLUSIONSResponse rates to PD‐1 blockade in patients with acral and mucosal melanomas were comparable to the published rates in patients with cutaneous melanoma and support the routine use of PD‐1 blockade in clinical practice. Further investigation is needed to identify the mechanisms of response and resistance to therapy in these subtypes. Cancer 2016;122:3354–3362. © 2016 American Cancer Society.
Isolation and Assessment of Single Long‐Term Reconstituting Hematopoietic Stem Cells from Adult Mouse Bone Marrow
Authors: Kent David G. , Dykstra Brad J. , Eaves Connie J. 
Published: August 2016

AbstractHematopoietic stem cells with long‐term repopulating activity can now be routinely obtained at purities of 40% to 50% from suspensions of adult mouse bone marrow. Here we describe robust protocols for both their isolation as CD45+EPCR+CD150+CD48− (ESLAM) cells using multiparameter cell sorting and for tracking their clonal growth and differentiation activity in irradiated mice transplanted with single ESLAM cells. The simplicity of these procedures makes them attractive for characterizing the molecular and biological properties of individual hematopoietic stem cells with unprecedented power and precision. © 2016 by John Wiley & Sons, Inc.
Derivation of Transgene‐Free Induced Pluripotent Stem Cells from a Single Drop of Blood
Authors: Chen Hong Yu , Tan Hong‐Kee , Loh Yuin‐Han 
Published: August 2016

AbstractHuman‐induced pluripotent stem cells (hiPSCs) have great potential for future use in therapeutic regenerative medicine. Based on the current protocol for deriving hiPSCs, invasive procedures such as skin biopsies and venipuncture are required for obtaining donor samples. Herein, we present a detailed protocol for deriving hiPSCs from human finger‐prick (FP) blood. In this method, the transgene‐free hiPSCs can be easily generated from only 10 µl of FP blood. The finger‐pricked iPSCs (FPiPSCs) show all the pluripotency markers and can be easily differentiated into various cell lineages. The time required for deriving the FPiPSCs is relatively short—10 to 15 days for FP blood expansion and 20 to 30 days for reprogramming. This method can be easily adapted for setting up a large scale iPSC bank as it requires only 10 µl of the donor FP blood, which can be easily collected. © 2016 by John Wiley & Sons, Inc.
Small‐Molecule‐Directed Hepatocyte‐Like Cell Differentiation of Human Pluripotent Stem Cells
Authors: Mathapati Santosh , Siller Richard , Impellizzeri Agata A.R. , Lycke Max , Vegheim Karianne , Almaas Runar , Sullivan Gareth J. 
Published: August 2016

AbstractHepatocyte‐like cells (HLCs) generated in vitro from human pluripotent stem cells (hPSCs) provide an invaluable resource for basic research, regenerative medicine, drug screening, toxicology, and modeling of liver disease and development. This unit describes a small‐molecule‐driven protocol for in vitro differentiation of hPSCs into HLCs without the use of growth factors. hPSCs are coaxed through a developmentally relevant route via the primitive streak to definitive endoderm (DE) using the small molecule CHIR99021 (a Wnt agonist), replacing the conventional growth factors Wnt3A and activin A. The small‐molecule‐derived DE is then differentiated to hepatoblast‐like cells in the presence of dimethyl sulfoxide. The resulting hepatoblasts are then differentiated to HLCs with N‐hexanoic‐Tyr, Ile‐6 aminohexanoic amide (Dihexa, a hepatocyte growth factor agonist) and dexamethasone. The protocol provides an efficient and reproducible procedure for differentiation of hPSCs into HLCs utilizing small molecules. © 2016 by John Wiley & Sons, Inc.
Multifunctional Single‐Site Catalysts for Alkoxycarbonylation of Terminal Alkynes
Authors: Chen Xingkun , Zhu Hejun , Wang Wenlong , Du Hong , Wang Tao , Yan Li , Hu Xiangping , Ding Yunjie 
Published: August 2016

AbstractA multifunctional copolymer (PyPPh2–SO3H@porous organic polymers, POPs) was prepared by combining acidic groups and heterogeneous P,N ligands through the copolymerization of vinyl‐functionalized 2‐pyridyldiphenylphosphine (2‐PyPPh2) and p‐styrene sulfonic acid under solvothermal conditions. The morphology and chemical structure of the copolymer were evaluated using a series of characterization techniques. Compared with traditional homogeneous Pd(OAc)2/2‐PyPPh2/ p‐toluenesulfonic acid catalyst, the copolymer supported palladium catalyst (Pd–PyPPh2–SO3H@POPs) exhibited higher activity for alkoxycarbonylation of terminal alkynes under the same conditions. This phenomenon could be attributed to the synergistic effect between the single‐site Pd centers, 2‐PyPPh2 ligands, and SO3H groups, the outstanding swelling properties as well as the high enrichment of the reactant concentration by the porous catalyst. In addition, the catalyst could be reused at least 4 times without any apparent loss of activity. The excellent catalytic reactivity and good recycling properties make it an attractive catalyst for industrial applications. This work paves the way for advanced multifunctional porous organic polymers as a new type of platform for heterogeneous catalysis in the future.
Low‐Pressure Vapor‐Assisted Solution Process for Thiocyanate‐Based Pseudohalide Perovskite Solar Cells
Authors: Chiang Yu‐Hsien , Cheng Hsin‐Min , Li Ming‐Hsien , Guo Tzung‐Fang , Chen Peter 
Published: August 2016

AbstractIn this report, we fabricated thiocyanate‐based perovskite solar cells with low‐pressure vapor‐assisted solution process (LP‐VASP) method. Photovoltaic performances are evaluated with detailed materials characterizations. Scanning electron microscopy images show that SCN‐based perovskite films fabricated using LP‐VASP have long‐range uniform morphology and large grain sizes up to 1 μm. The XRD and Raman spectra were employed to observe the characteristic peaks for both SCN‐based and pure CH3NH3PbI3 perovskite. We observed that the Pb(SCN)2 film transformed to PbI2 before the formation of perovskite film. X‐ray photoemission spectra (XPS) show that only a small amount of S remained in the film. Using LP‐VASP method, we fabricated SCN‐based perovskite solar cells and achieved a power conversion efficiency of 12.72 %. It is worth noting that the price of Pb(SCN)2 is only 4 % of PbI2. These results demonstrate that pseudo‐halide perovskites are promising materials for fabricating low‐cost perovskite solar cells.
Development of an Iridium‐Based Catalyst for High‐Pressure Evolution of Hydrogen from Formic Acid
Authors: Iguchi Masayuki , Himeda Yuichiro , Manaka Yuichi , Kawanami Hajime 
Published: August 2016

AbstractA highly efficient and recyclable Ir catalyst bearing a 4,7‐dihydroxy‐1,10‐phenanthroline ligand was developed for the evolution of high‐pressure H2 gas (>100 MPa), and a large amount of atmospheric pressure H2 gas (>120 L), over a long term (3.5 months). The reaction proceeds through the dehydrogenation of highly concentrated aqueous formic acid (FA, 40 vol %, 10 mol L−1) at 80 °C using 1 μmol of catalyst, and a turnover number (TON) of 5 000 000 was calculated. The Ir catalyst precipitated after the reaction owing to its pH‐dependent solubility in water, and 94 mol % was recovered by filtration. Thus, it can be treated and recycled like a heterogeneous catalyst. The catalyst was successfully recycled over 10 times for highpressure FA dehydrogenation at 22 MPa without any treatment or purification.
Ni Nanoparticles Supported on Cage‐Type Mesoporous Silica for CO2 Hydrogenation with High CH4 Selectivity
Authors: Budi Canggih Setya , Wu Hung‐Chi , Chen Ching‐Shiun , Saikia Diganta , Kao Hsien‐Ming 
Published: August 2016

AbstractNi nanoparticles (around 4 nm diameter) were successfully supported on cage‐type mesoporous silica SBA‐16 (denoted as Ni@SBA‐16) via wet impregnation at pH 9, followed by the calcination‐reduction process. The Ni@SBA‐16 catalyst with a very high Ni loading amount (22.9 wt %) exhibited exceptionally high CH4 selectivity for CO2 hydrogenation. At a nearly identical loading amount, the Ni@SBA‐16 catalysts with smaller particle size of Ni NPs surprisingly exhibited a higher catalytic activity of CO2 hydrogenation and also led to a higher selectivity on CH4 formation than the Ni@SiO2 catalysts. This enhanced activity of the Ni@SBA‐16 catalyst is suggested to be an accumulative result of the advantageous structural properties of the support SBA‐16 and the well confined Ni NPs within the support; both induced a favorable reaction pathway for high selectivity of CH4 in CO2 hydrogenation.
ESIM‐OFDM‐based transceiver design of a visible light communication system
Authors: Ahsan M. , Asif H. M. 
Published: August 2016

SummaryVisible light communication (VLC) system has been becoming a potential technology for short‐range data communication over wireless optical channel. In this paper, a real‐time state‐of‐the‐art VLC system prototype is implemented mainly based on enhanced subcarrier index modulation orthogonal frequency division multiplexing (ESIM‐OFDM) modulation scheme. The prototype has been designed using NI cDAQ hardware equipment programmed in matlab/labview. In other words, the developed VLC transceiver labview model is loaded into cDAQ to perform real‐time transmission of text data. The design mainly comprises VLC transmitter, VLC receiver, interfacing NI cDAQ with labview, and implementation of ESIM‐OFDM. It should be noted that the direct output of ESIM‐OFDM is not suitable to drive VLC transmitter circuit; therefore, the key contribution lies in making use of sigma–delta modulator to modify ESIM‐OFDM output to produce constant current signal which in turn could drive VLC transmitter. The second main contribution of the work targets the luminous properties of the designed transmitter that have experimentally been characterized using a LUX meter. Finally, the last contribution of the work is the simulation carried out to analyze the performance of the proposed system with other existing VLC modulation schemes. Copyright © 2016 John Wiley & Sons, Ltd.
Pou4f2‐GFP knock‐in mouse line: A model for studying retinal ganglion cell development
Authors: Zheng Dongwang , Yang Xiaoyan , Sheng Donglai , Yu Dongliang , Liang Guoqing , Guo Luming , Xu Mei , Hu Xu , He Daqiang , Yang Yang , Wang Yuying 
Published: August 2016

SummaryPou4f2 acts as a key node in the comprehensive and step‐wise gene regulatory network (GRN) and regulates the development of retinal ganglion cells (RGCs). Accordingly, deletion of Pou4f2 results in RGC axon defects and apoptosis. To investigate the GRN involved in RGC regeneration, we generated a mouse line with a POU4F2‐green fluorescent protein (GFP) fusion protein expressed in RGCs. Co‐localization of POU4F2 and GFP in the retina and brain of Pou4f2‐GFP/+ heterozygote mice was confirmed using immunofluorescence analysis. Compared with those in wild‐type mice, the expression patterns of POU4F2 and POU4F1 and the co‐expression patterns of ISL1 and POU4F2 were unaffected in Pou4f2‐GFP/GFP homozygote mice. Moreover, the quantification of RGCs showed no significant difference between Pou4f2‐GFP/GFP homozygote and wild‐type mice. These results demonstrated that the development of RGCs in Pou4f2‐GFP/GFP homozygote mice was the same as in wild‐type mice. Thus, the present Pou4f2‐GFP knock‐in mouse line is a useful tool for further studies on the differentiation and regeneration of RGCs.