bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causal relationship between primary headache mediated by circulating cytokines and cerebral cortex structure: a mediation Mendelian randomization study
Authors: Zheng Tao , Zeng Na , Li Guanglu , Lin Shicheng , Yu Binyang , Yuan Jian , Duan Shaojie , Wang Gesheng , Liu Zunjing 
Published: September 2024

Abstract
Inflammation may be related to structural changes in the cerebral cortex. We aimed to explore whether cytokines mediate the link between these changes and primary headache. The summary statistics of genome-wide association study (GWAS) related to migraine and its subtypes, cluster headache were derived from the FinnGen Release 10 database, and tension-type headache data was from the GWAS Catalog. Ninety-one cytokines were obtained from genome-wide pQTL mapping data. GWAS data on cortical surface area (SA) and thickness (TH) came from the ENIGMA Consortium. The methods of Mendelian randomization (MR) analysis included the inverse-variance-weighted (IVW), MR-Egger, and weighted median. Migraine reduces the SA of paracentral[β = −1.3645, OR = 0.2555, 95%CI (0.0660, 0.9898)] by fibroblast growth factor-23(FGF-23), with an intermediate ratio (IR) of 38.13%. Migraine may reduce the TH of superior parietal[β = −0.0029, OR = 0.9971, 95%CI (0.9943, 0.9999)] by interleukin (IL)-15RA, with an absolute IR of 11.11%. Migraine without aura may reduce the TH of rostral anterior cingulate[β = −0.0005, OR = 0.9995, 95%CI (0.9991, 0.9999)] by IL-18R1, with an IR of 11.63%. FGF23 and IL-15RA are associated with reduced SA or TH in migraine, while IL-18R1 is associated with increased TH in migraine without aura.
Theoretical model for the elastic properties of cracked fluid-saturated rocks considering the crack connectivity
Authors: Wang Pu , Cui Yi-an , Li Jingye , Liu Jianxin 
Published: September 2024

SUMMARY
Cracks are a common rock microstructure and have a large effect on elastic properties during wave propagation. The fluid flow between a crack and its adjacent pore space can cause wave attenuation and dispersion. In this work, we introduce a crack connectivity parameter which is meant to improve the expression of local flow by weighting the contributions of fully connected and isolated cracks. We then update the analytical expression for frequency-dependent moduli by modifying the boundary conditions of the linearized Navier–Stokes equation and mass conservation equation. The proposed model contains the effect of cracks and stiff pores, in which the attenuation and dispersion are determined by squirt-flow and stiff-pore relaxations. The resulting model shows the squirt-flow relaxation frequency depends on not only the crack aspect ratio but also the crack connectivity. However, their contributions are different. The crack connectivity has little effect on the attenuation amplitude of shear modulus, but affects the attenuation amplitude of bulk modulus when multiple sets of cracks exist in the rock. The attenuation frequency band is also affected by the crack connectivity. As the crack connectivity deteriorates, the attenuation peak moves to low frequencies. In addition, by comparing the crack connectivity with the fluid viscosity coefficient, it is observed that the crack connectivity only affects the attenuation frequency band of cracks, whereas the fluid viscosity coefficient affects the attenuation frequency bands of cracks and stiff pores simultaneously. Thus, the introduction of crack connectivity is a supplement to the theoretical model of cracked fluid-saturated rocks. It helps understand the local fluid flow induced by seismic waves and provides a reasonable variation analysis of moduli and attenuation, especially for tight reservoirs.
Variational prior replacement in Bayesian inference and inversion
Authors: Zhao Xuebin , Curtis Andrew 
Published: September 2024

SUMMARYMany scientific investigations require that the values of a set of model parameters are estimated using recorded data. In Bayesian inference, information from both observed data and prior knowledge is combined to update model parameters probabilistically by calculating the posterior probability distribution function. Prior information is often described by a prior probability distribution. Situations arise in which we wish to change prior information during the course of a scientific project. However, estimating the solution to any single Bayesian inference problem is often computationally costly, as it typically requires many model samples to be drawn, and the data set that would have been recorded if each sample was true must be simulated. Recalculating the Bayesian inference solution every time prior information changes can therefore be extremely expensive. We develop a mathematical formulation that allows the prior information that is embedded within a solution, to be changed using variational methods, without recalculating the original Bayesian inference. In this method, existing prior information is removed from a previously obtained posterior distribution and is replaced by new prior information. We therefore call the methodology variational prior replacement (VPR). We demonstrate VPR using a 2-D seismic full waveform inversion example, in which VPR provides similar posterior solutions to those obtained by solving independent inference problems using different prior distributions. The former can be completed within minutes on a laptop computer, whereas the latter requires days of computations using high-performance computing resources. We demonstrate the value of the method by comparing the posterior solutions obtained using three different types of prior information: uniform, smoothing and geological prior distributions.
Efficacy and safety of co-trimoxazole in device-related bone and joint infections: a CRIOGO multicentre case–control study
Authors: Lecomte Raphaël , Deschanvres Colin , Le Bourgeois Amandine , Bart Géraldine , Mahieu Rafaël , Le Moal Gwénaël , Ansart Séverine , Asseray Nathalie , Ruffier d’Epenoux Louise , Corvec Stéphane , Boutoille David ,   CRIOGO network, Abgueguen Pierre , Caubrière Marin , Lemarie Carole , Chenouard Rachel , Pailhories Hélène , Vildy Amandine , Ansart Séverine , Quaesaet Luc , Stindel Eric , Tandé Didier , Lamoureux Claudie , Greves Anaïs , Boutoille David , Lecomte Raphaël , Deschanvres Colin , Asquier-Khati Antoine , Chauveau Marie , Gaborit Benjamin , Nich Christophe , Crenn Vincent , Bémer Pascale , Corvec Stéphane , d’Epenoux Louise Ruffier , Paquin Axelle , Grégoire Matthieu , Bourigault Céline , Plantard Barbara , Cazenave-Roblot France , Moal Gwenaël Le , Pries Pierre , Plouzeau-Jayle Chloé , Thomas Céline , Arvieux Cédric , Baldeyrou Marion , Common Harold , Cattoir Vincent , Reissier Sophie , Méheut Anne , Bernard Louis , Lemaignen Adrien , Lacasse Marion , Rosset Philippe , Nail Louis-Romée Le , Lartigue Marie-Frédérique , Laplaige Isabelle , Chaufour Laura 
Published: September 2024

Abstract

Objectives
Co-trimoxazole could be an alternative antibiotic to treat device-related bone and joint infection (BJI) but there are few published data about its efficacy and safety in this complex scenario to treat infection. The objective was to compare the outcome of patients with device-related BJI treated with an antibiotic regimen including co-trimoxazole versus a regimen without co-trimoxazole.

Methods
This multicentre case–control study included consecutive adult patients diagnosed with device-related BJI. Each patient receiving co-trimoxazole was included in the co-trimoxazole group and was matched with two control patients, with stratification on microbial aetiology and age. The primary outcome was composite and defined by death or treatment failure during the follow-up.

Results
In this study, 150 patients were included, 50 in the co-trimoxazole group and 100 in the control group. The rate of reaching the primary endpoint was 18% in the co-trimoxazole group (9/50 cases) versus 21% in the control group (21/100) (P = 0.66). Co-trimoxazole use was not associated with an unfavourable outcome in the multivariate analysis (adjusted OR 0.8, 95% CI 0.31–2.06, P = 0.64). Although no significant difference was observed in premature discontinuation of treatment due to an adverse event between both groups (14 versus 12%, P = 0.73), treatment-related adverse events were significantly more frequently reported in patients of the co-trimoxazole group than the control group [34% (17/50) versus 18% (18/100), P = 0.03].

Conclusions
Co-trimoxazole appears to be an effective alternative for the treatment of BJI, even when it occurs on a device, but the safety profile requires close monitoring of adverse effects.
Heterologous expression of sulfur: quinone oxidoreductase (Sqr) to improve Thioalkalivibrio versutus D301 desulfurization performance
Authors: Tian Zhuang , Yu Chenxi , Li He , Song Bin , Lv Jianwei , Liu Chuang , Sun Wanting , Hu Xiao , Xiong Yixi , Liu Jinlong , Cheng Xiyu , Yang Maohua , Xing Jianmin 
Published: September 2024

Abstract

Aims
Heterologous expression of sulfur: quinone oxidoreductase (Sqr) from Halomonas mongoliensis JS01, which is responsible for oxidizing sulfide to elemental sulfur, in Thioalkalivibrio versutus (T. versutus) D301 improves desulfurization.

Methods and results
We expressed sqr in T. versutus D301 by conjugative transfer and then assayed its desulfurization capacity in an airlift reactor and analyzed its transcriptome at −380 mV ORP. Our findings demonstrate that the D301-sqr+ strain, utilizing sodium sulfide as a sulfur source under optimal ORP conditions (−380 mV), achieved an elemental sulfur yield of 95%. This represents an 8% increase over the T. versutus D301. Moreover, the sodium sulfide utilization rate for D301-sqr+ showed a marked improvement [0.741 vs. 0.651 mmol∙(l·h)−1], with a concurrent increase in the rate of elemental sulfur production when compared to the T. versutus D301 (0.716 vs. 0.518 mmol ∙(l·h)−1). Transcriptome analysis revealed that the flavocytochrome c (fcc) and the sox system were differentially transcriptionally down-regulated in D301-sqr+ compared with the T. versutus D301.

Conclusions
Heterologous expression of the gene sqr altered the transcription of related genes in T. versutus D301 sulfur oxidation pathway, increasing the yield of elemental sulfur and the rate of sulfur oxidation, and making D301-sqr+ more potential for industrial applications.
Elucidating the bacterial inactivation mechanism by argon cold atmospheric pressure plasma jet through spectroscopic and imaging techniques
Authors: Das Sarthak , Mohapatra Sarita , Kar Satyananda 
Published: September 2024

Abstract

Aims
This study aims to assess the potential bacterial inactivation pathway triggered by argon (Ar) cold atmospheric pressure plasma jet (CAPJ) discharge using spectroscopic and imaging techniques.

Methods and results
Electrical and reactive species of the Ar CAPJ discharge was characterized. The chemical composition and morphology of bacteria pre- and post-CAPJ exposure were assessed using Fourier transform infrared (FTIR), Raman micro-spectroscopy, and transmission electron microscopy (TEM). A greater than 6 log reduction of Escherichia coli and Staphylococcus aureus was achieved within 60 and 120 s of CAPJ exposure, respectively. Extremely low D-values (&lt;20 s) were recorded for both the isolates. The alterations in the FTIR spectra and Raman micro-spectra signals of post-CAPJ exposed bacteria revealed the degree of destruction at the molecular level, such as lipid peroxidation, protein oxidation, bond breakages, etc. Further, TEM images of exposed bacteria indicated the incurred damages on cell morphology by CAPJ reactive species. Also, the inactivation process varied for both isolates, as evidenced by the correlation between the inactivation curve and FTIR spectra. It was observed that the identified gas-phase reactive species, such as Ar I, O I, OH•, NO+, OH+, NO2−, NO3−, etc. played a significant role in bacterial inactivation.

Conclusions
This study clearly demonstrated the effect of CAPJ exposure on bacterial cell morphology and molecular composition, illuminating potential bacterial inactivation mechanisms.
Features and prognostic significance of soluble TIM-3 and its ligands Gal-9 and CEACAM1 levels in the diagnostic bone marrow of adult acute myeloid leukemia patients
Authors: Shi Zong-Yan , Sun Kai , Xie Dai-Hong , Wang Ya-Zhe , Jiang Hao , Jiang Qian , Huang Xiao-Jun , Qin Ya-Zhen 
Published: September 2024

Abstract
The prognostic significance of soluble immune checkpoint molecule TIM-3 and its ligands in the plasma has been illustrated in various solid tumors, but such study in newly diagnosed acute myeloid leukemia (AML) remains absent. Soluble TIM-3, Gal-9, and CEACAM1 levels in bone marrow plasma samples collected from 90 adult AML patients at diagnosis and 12 healthy donors were measured by enzyme-linked immunosorbent assays, and 16 AML patients were simultaneously tested cell membrane TIM-3 expression by multicolor flow cytometry. AML patients had significantly elevated soluble TIM-3 levels and similar soluble Gal-9 and CEACAM1 levels compared with healthy donors (P = 0.0003, 0.26, and 0.96, respectively). In the whole cohort, a high soluble TIM-3 level was the sole independent adverse prognostic factor for relapse-free survival (RFS) (P = 0.0060), and together with adverse European LeukemiaNet genetic risk they were independent poor prognostic factors for event-free survival (P = 0.0030 and 0.0040, respectively). A high soluble CEACAM1 level was significantly related to lower RFS (P = 0.028). In addition, a high soluble Gal-9 level had a significant association with lower RFS in patients receiving allogeneic hematopoietic stem cell transplantation at the first complete remission (P = 0.037). Furthermore, soluble TIM-3 level tended to have positive correlation with the percentage of nonblast myeloid TIM-3+ cells in nucleated cells in AML (r = 0.48, P = 0.073). Therefore, the high soluble TIM-3 level in the diagnostic BM plasma predicted poor outcome in adult AML patients, and a high sGal-9 level was associated with relapse after allogeneic hematopoietic stem cell transplantation.
When Polanyi Met Competition Policy: Market Fundamentalism, Crisis, and Reform in The 21ST Century
Authors: Sadami Arthur , dos Santos Mateus Bernardes 
Published: September 2024

Abstract
Karl Polanyi and his analytical framework in economic sociology remain overlooked by competition policy scholarship. Notably, the concept of “embeddedness”, central to Polanyi’s contribution, offers a valuable perspective to trace the development of this regulatory mechanism over time. The social and political concerns of an emerging industrial society marked the birth of competition policy as a device for embedding the early 20th-century market economy. However, in the following decades, new market fundamentalist narratives disembedded markets, with competition policy contributing to this process by deviating from its non-market origins. Today, this governance tool faces the challenges of 21st-century civilization, with the celebrated consensus on its principles long lost. New social and political concerns arising from market power demand the re-embedment of markets through competition. This article explores this Polanyian dynamic of embeddedness-disembeddedness-re-embeddedness by reframing the history of competition policy in different institutional realities—the United States, the EU, and Brazil. It also discusses how diverse institutional conditions shaped alternative responses towards market fundamentalism throughout the past century. The revival of Polanyi’s ideas not only helps us understand how we arrived here but also provides important insights into the inevitable role that “non-market” dimensions play in the reform agenda currently surrounding competition policy.
Gastrointestinal bleeding caused by splenic artery pseudoaneurysm in chronic pancreatitis: a case report and literature review
Authors: Liu Chenyao , Zhu Qingliang , Zhang Hailong , Wang Zhongqiong 
Published: September 2024

Abstract
Pseudoaneurysm of the splenic artery is a rare vascular complication of chronic pancreatitis, with a high mortality rate. Haemorrhage and abdominal pain are the most common manifestations, and so far there are no literature reviews on the rare complication of splenic artery pseudoaneurysm due to chronic pancreatitis. Therefore, we describe a male patient with worsening haemochezia and upper abdominal pain, who had been hospitalized repeatedly for ‘pancreatitis’ 1 year ago, and relevant investigations confirmed a pseudoaneurysm of the splenic artery, which was successfully treated by transarterial embolization, and a literature review is also presented.
A rare case of superior mesenteric venous and portal vein thrombosis in complicated appendicitis
Authors: Bustamante John Paul , Caplan Claire , Sajdlowska Joanna , Hooda Zamaan , Warta Melissa 
Published: September 2024

Abstract
Superior mesenteric venous (SMV) thrombosis is a rare complication of severe appendicitis. Early recognition is due to improved imaging modalities, which ultimately lead to more prompt intervention. Despite being an uncommon phenomenon, SMV thrombosis can have complications stemming from venous hypertension, such as gastric and esophageal varices, bowel ischemia, sepsis, and death. As this is a rare phenomenon, specific treatment guidelines and algorithms are lacking in the current literature. This case report describes a 23-year-old male patient whose recovery from a laparoscopic appendectomy was complicated with both an SMV and portal vein thrombosis.
Does the response of Rubisco and photosynthesis to elevated [CO2] change with unfavourable environmental conditions?
Authors: Ancín María , Gámez Angie L , Jauregui Ivan , Galmes Jeroni , Sharwood Robert E , Erice Gorka , Ainsworth Elizabeth A , Tissue David T , Sanz-Sáez Alvaro , Aranjuelo Iker 
Published: September 2024

Abstract
Climate change due to anthropogenic CO2 emissions affects plant performance globally. To improve crop resilience, we need to understand the effects of elevated CO2 concentration (e[CO2]) on CO2 assimilation and Rubisco biochemistry. However, the interactive effects of e[CO2] and abiotic stress are especially unclear. This study examined the CO2 effect on photosynthetic capacity under different water availability and temperature conditions in 42 different crop species, varying in functional group, photosynthetic pathway, and phenological stage. We analysed close to 3000 data points extracted from 120 published papers. For C3 species, e[CO2] increased net photosynthesis and intercellular [CO2], while reducing stomatal conductance and transpiration. Maximum carboxylation rate and Rubisco in vitro extractable maximal activity and content also decreased with e[CO2] in C3 species, while C4 crops are less responsive to e[CO2]. The interaction with drought and/or heat stress did not significantly alter these photosynthetic responses, indicating that the photosynthetic capacity of stressed plants responded to e[CO2]. Moreover, e[CO2] had a strong effect on the photosynthetic capacity of grasses mainly in the final stages of development. This study provides insight into the intricate interactions within the plant photosynthetic apparatus under the influence of climate change, enhancing the understanding of mechanisms governing plant responses to environmental parameters.
Towards a universal analytical model for Population III star formation: interplay between feedback and fragmentation
Authors: Liu Boyuan , Gurian James , Inayoshi Kohei , Hirano Shingo , Hosokawa Takashi , Bromm Volker , Yoshida Naoki 
Published: September 2024

ABSTRACT
JWST has brought us new insights into Cosmic Dawn with tentative detection of the unique signatures of metal-free Population III (Pop III) stars, such as strong He II emission, extremely blue ultraviolet spectrum, and enhanced nitrogen abundance. Self-consistent theoretical predictions of the formation rates, sites, and masses of Pop III stars are crucial for interpreting the observations, but are challenging due to complex physical processes operating over the large range of length-scales involved. One solution is to combine analytical models for the small-scale star formation process with cosmological simulations that capture the large-scale physics such as structure formation, radiation backgrounds, and baryon-dark matter streaming motion that regulate the conditions of Pop III star formation. We build an analytical model to predict the final masses of Pop III stars/clusters from the properties of star-forming clouds, based on the key results of small-scale star formation simulations and stellar evolution models. Our model for the first time considers the interplay between feedback and fragmentation and covers different modes of Pop III star formation ranging from ordinary small ($\sim\!{10{-}2000}\ \rm M_\odot$) clusters in molecular-cooling clouds to massive ($\gtrsim\!{10^{4}}\ \rm M_\odot$) clusters containing supermassive ($\sim\!{10^{4}{-}3}\times 10^{5}\ \rm M_\odot$) stars under violent collapse of atomic-cooling clouds with large gas accretion rates of $\gtrsim\!{0.1}\ \rm M_\odot \ yr^{-1}$. As an example, the model is applied to the Pop III star-forming clouds in the progenitors of typical haloes hosting high-z luminous quasars ($M_{\rm h}\sim 10^{12}\ \rm M_\odot$ at $z\sim 6$), which shows that formation of Pop III massive clusters is common ($\sim\!{20{-}70}{{\ \rm per\ cent}}$) in such biased ($\sim\!{4}\sigma$) regions, and the resulting heavy black hole seeds from supermassive stars can account for a significant fraction of observed luminous ($\gtrsim\!{10^{46}}\ \rm erg\ s^{-1}$) quasars at $z\sim 6$.
Multimessenger signatures of delayed choked jets in tidal disruption events
Authors: Mukhopadhyay Mainak , Bhattacharya Mukul , Murase Kohta 
Published: September 2024

ABSTRACT
Recent radio observations and coincident neutrino detections suggest that some tidal disruption events (TDEs) exhibit late-time activities, relative to the optical emission peak, and these may be due to delayed outflows launched from the central supermassive black hole. We investigate the possibility that jets launched with a time delay of days to months, interact with a debris that may expand outwards. We discuss the effects of the time delay and expansion velocity on the outcomes of jet breakout and collimation. We find that a jet with an isotropic-equivalent luminosity of $\lesssim 5 \times 10^{45}\, {\rm erg\, s}^{-1}$ is likely to be choked for a delay time of $\sim 3$ months. We also study the observational signatures of such delayed choked jets. The jet–debris interaction preceding the breakout would lead to particle acceleration and the resulting synchrotron emission can be detected by current and near-future radio, optical and X-ray telescopes, and the expanding jet-driven debris could explain late-time radio emission. We discuss high-energy neutrino production in delayed choked jets, and the time delay can significantly alleviate the difficulty of the hidden jet scenario in explaining neutrino coincidences.