bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of Single-Layer g-C3N4/Ag Hybrids for Surface-Enhanced Raman Scattering (SERS)
Authors: Jiang Jizhou , Zou Jing , Wee Andrew Thye Shen , Zhang Wenjing 
Published: September 2016

AbstractSurface-enhanced Raman scattering (SERS) substrates with high activity and stability are desirable for SERS sensing. Here, we report a new single atomic layer graphitic-C3N4 (S-g-C3N4) and Ag nanoparticles (NPs) hybrid as high-performance SERS substrates. The SERS mechanism of the highly stable S-g-C3N4/Ag substrates was systematically investigated by a combination of experiments and theoretical calculations. From the results of XPS and Raman spectroscopies, it was found that there was a strong interaction between S-g-C3N4 and Ag NPs, which facilitates the uniform distribution of Ag NPs over the edges and surfaces of S-g-C3N4 nanosheets, and induces a charge transfer from S-g-C3N4 to the oxidizing agent through the silver surface, ultimately protecting Ag NPs from oxidation. Based on the theoretical calculations, we found that the net surface charge of the Ag atoms on the S-g-C3N4/Ag substrates was positive and the Ag NPs presented high dispersibility, suggesting that the Ag atoms on the S-g-C3N4/Ag substrates were not likely to be oxidized, thereby ensuring the high stability of the S-g-C3N4/Ag substrate. An understanding of the stability mechanism in this system can be helpful for developing other effective SERS substrates with long-term stability.
P3BSseq: parallel processing pipeline software for automatic analysis of bisulfite sequencing data
Authors: Luu Phuc-Loi , Gerovska Daniela , Arrospide-Elgarresta Mikel , Retegi-Carrión Sugoi , Schöler Hans R , Araúzo-Bravo Marcos J 
Published: September 2016

Abstract

Motivation
Bisulfite sequencing (BSseq) processing is among the most cumbersome next generation sequencing (NGS) applications. Though some BSseq processing tools are available, they are scattered, require puzzling parameters and are running-time and memory-usage demanding.

Results
We developed P3BSseq, a parallel processing pipeline for fast, accurate and automatic analysis of BSseq reads that trims, aligns, annotates, records the intermediate results, performs bisulfite conversion quality assessment, generates BED methylome and report files following the NIH standards. P3BSseq outperforms the known BSseq mappers regarding running time, computer hardware requirements (processing power and memory use) and is optimized to process the upcoming, extended BSseq reads. We optimized the P3BSseq parameters for directional and non-directional libraries, and for single-end and paired-end reads of Whole Genome and Reduced Representation BSseq. P3BSseq is a user-friendly streamlined solution for BSseq upstream analysis, requiring only basic computer and NGS knowledge.

Availability and Implementation
P3BSseq binaries and documentation are available at: http://sourceforge.net/p/p3bsseq/wiki/Home/

Supplementary information
Supplementary data are available at Bioinformatics online.
Le Site d’auteur: un nouvel espace d’investigation critique
Authors: Hoffmann Benjamin 
Published: September 2016

Abstract
Cet article cherche à délimiter un nouvel espace d’investigation critique: le site internet d’auteur. Sa thèse centrale consiste à démontrer que la fonction de ce dernier excède sa finalité commerciale. Un nombre grandissant de sites internet mis en ligne par des écrivains contemporains diffusent des paratextes produits spécifiquement pour y trouver place: le partage en ligne de réflexions sur le travail littéraire fait du journal de l’écrivain un livre ouvert aux internautes. Par ailleurs, la publication en ligne de textes inédits témoigne de la capacité de cet espace de médiation à devenir un lieu de création à part entière. Cette étude s’appuie sur les résultats d’un questionnaire auquel ont répondu Antoine Bello, François Bon, Joël Dicker, Michaël Ferrier, Fabrice Humbert, Marc Levy, Édouard Louis, Marc Pautrel, Pia Petersen, Jean Rouaud, Gilbert Sinoué et Audrée Wilhelmy. Après avoir analysé les réponses fournies à ce questionnaire, cette étude s’interroge sur la capacité du site internet à offrir une forme de musée virtuel pour l’écrivain, rassemblant à la fois ses œuvres et les interventions critiques à leur sujet et opposant à la destruction et l’éparpillement des textes un nouvel accès, par l’intermédiaire du numérique, à la postérité.
The inherited patient on opioids
Authors: Owston Christopher L. 
Published: September 2016

ABSTRACT
Chronic pain is a common problem, affecting more than 100 million people in the United States, and primary care providers are highly likely to encounter patients on chronic opioid therapy. Initial encounters with a new patient already on high-dose opioids can be difficult and lead to apprehension for both patient and provider. This article describes how to use current opioid prescribing guidelines, conduct a comprehensive pain assessment, and implement risk mitigation strategies to improve patient safety and effectively manage this patient population.
HINTS for differentiating peripheral from central causes of vertigo
Authors: Jaynstein Dayna 
Published: September 2016

ABSTRACT
Dizziness and vertigo are common and difficult complaints encountered by providers. The differential diagnosis is large and varies from benign to life-threatening disorders. The true challenge becomes differentiating benign peripheral vertigo from central vertigo. The HINTS examination can help differentiate peripheral from central causes of dizziness and vertigo.
Takayasu arteritis: an update
Authors: Seyahi Emire 
Published: September 2016

Purpose of review
Takayasu arteritis has long been considered as an uncommon disease, rather specific to the Far-East; however recent surveys show that the disease can be seen in all ethnicities around the world with increasing prevalence rates. Nowadays, it would not be fair to consider Takayasu arteritis as a rare disease.

Recent findings
Although involvement of the thoracic aorta and its branches was more common among females, males had a tendency toward limited involvement of the abdominal aorta and its branches. Pregnancy seems to cause serious risks for both maternal and fetal health. Takayasu arteritis frequently coexist with inflammatory bowel diseases and the two diseases may have common genetic background and molecular pathways. New imaging tools such as computerized tomography or magnetic resonance angiography, fludeoxyglucose positron emission tomography-computerized tomography and recently contrast-enhanced ultrasonography are frequently used in the diagnosis and to assess vascular inflammation. Accumulating evidence shows that biological agents such as anti-tumor necrosis factor agents, tocilizumab and rituximab could be used effectively in refractory cases. The restenosis or occlusion risks are still high with vascular interventions. The mortality seems to be decreasing in recent years.

Summary
The ethiopathogenesis of the disease should be clarified. Our feature goals should be to discriminate better active inflammation from quiescent disease enabling more effective treatment.
Healthcare Resource Use and Costs in Long-Term Survivors of Acute Respiratory Distress Syndrome: A 5-Year Longitudinal Cohort Study*
Authors: Ruhl A. Parker , Huang Minxuan , Colantuoni Elizabeth , Lord Robert K. , Dinglas Victor D. , Chong Alexandra , Sepulveda Kristin A. , Mendez-Tellez Pedro A. , Shanholtz Carl B. , Steinwachs Donald M. , Pronovost Peter J. , Needham Dale M. 
Published: September 2016

Objective:
To evaluate the time-varying relationship of annual physical, psychiatric, and quality of life status with subsequent inpatient healthcare resource use and estimated costs.

Design:
Five-year longitudinal cohort study.

Setting:
Thirteen ICUs at four teaching hospitals.

Patients:
One hundred thirty-eight patients surviving greater than or equal to 2 years after acute respiratory distress syndrome.

Interventions:
None.

Measurements and Main Results:
Postdischarge inpatient resource use data (e.g., hospitalizations, skilled nursing, and rehabilitation facility stays) were collected via a retrospective structured interview at 2 years, with prospective collection every 4 months thereafter, until 5 years postacute respiratory distress syndrome. Adjusted odds ratios for hospitalization and relative medians for estimated episode of care costs were calculated using marginal longitudinal two-part regression. The median (interquartile range) number of inpatient admission hospitalizations was 4 (2–8), with 114 patients (83%) reporting greater than or equal to one hospital readmission. The median (interquartile range) estimated total inpatient postdischarge costs over 5 years were $58,500 ($19,700–157,800; 90th percentile, $328,083). Better annual physical and quality of life status, but not psychiatric status, were associated with fewer subsequent hospitalizations and lower follow-up costs. For example, greater grip strength (per 6 kg) had an odds ratio (95% CI) of 0.85 (0.73–1.00) for inpatient admission, with 23% lower relative median costs, 0.77 (0.69–0.87).

Conclusions:
In a multisite cohort of long-term acute respiratory distress syndrome survivors, better annual physical and quality of life status, but not psychiatric status, were associated with fewer hospitalizations and lower healthcare costs.
Hand Allograft Saved by an Ultrathin Groin Flap
Authors: Château Joseph , Gazarian Aram , Boucher Fabien , Badet Lionel , Braye Fabienne , Saint-Cyr Michel , Mojallal Ali 
Published: September 2016

Summary:
We report a case of a young double-hand allotransplant patient who presented with a full-thickness skin necrosis of the dorsum of the left hand after vascular compromise of the allotransplantation. Considering the lack of viable dorsal tissue overlying the extensor tendons and the need for early hand rehabilitation, an ultrathin pedicled groin flap was used for the coverage. This procedure resulted in salvaging the allotransplantation, and the patient was able to successfully return to work after his surgery. To our knowledge, this is the only case of an upper extremity allotransplant salvaged by a pedicled flap.
Bilateral Maxillary Reconstruction Using Fibular Flap in Bisphosphonate-related Osteonecrosis
Authors: Sotsuka Yohei , Fujiwara Toshihiro , Kawai Kenichiro , Nishimoto Soh , Kakibuchi Masao 
Published: September 2016

Summary:
Recent reports have shown successful transfer of vascularized fibular flap in bisphosphonate-induced mandibular osteonecrosis. We present a case of a 50-year-old patient who presented with bisphosphonate-related osteonecrosis of bilateral maxilla, which is reconstructed using a fibular flap.
A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease
Authors: Park Beau Y. , Leslie Kevin O. , Chen Longwen , Vaszar Laszlo T. , Cornella Jeffrey L. 
Published: September 2016

Abstract
Extrauterine spread of leiomyomas is rare and most commonly occurs in the lungs. We present a case of simultaneous metastatic leiomyomatosis to the lungs and peritoneal cavity following laparoscopic myomectomy with power morcellation. The patient presented to our institution for further management where she underwent a robotically assisted hysterectomy with bilateral salpingo-oophorectomy. Leiomyomatous implants measuring up to 2.4 cm were resected from bowel mesentery and bladder peritoneum. Subsequent serial computed tomography imaging confirmed stable pulmonary nodules without new intraperitoneal lesions. Increasing number of cases involving extrauterine spread of leiomyomas has been reported with the introduction of power morcellation. The exact pathogenesis is unknown but is likely multifactorial. We emphasize that although the incidence of spread of benign disease is low, it is important to recognize this phenomenon as we will likely continue to encounter similar cases in the coming years.
Communicating an arts foundation’s values: sights, sounds and social media
Authors: Wilks Linda 
Published: September 2016

Purpose
The purpose of this paper is to test and refine the long-established signal transmission model of the communication process by examining the ways in which a newly formed nonprofit arts foundation communicated its professed values to its stakeholders.

Design/methodology/approach
The study uses a mixed method case study approach. Interviews with key informants and observations of the foundation’s webpages enabled the identification of the professed values of the arts foundation. Next, a questionnaire survey established whether these values had been successfully decoded by stakeholders and identified the channels via which the values-related signals had been received.

Findings
The transmission model was found to be relevant as a model. However, to improve its fit within a nonprofit arts context, a modification to the model is suggested which highlights the importance of multi-sensory channels, the importance of context and the increasingly important role of the stakeholder.

Research limitations/implications
This study is a small-scale case study, although its mixed methods help to ensure validity.

Practical implications
The findings will help nonprofit arts organisations to decide how to best communicate their values to their stakeholders.

Social implications
The improved communications model will contribute to the enabling of organisations to uphold and transmit their values and thus improve society’s overall quality of life.

Originality/value
Literature which provides in-depth examination of the communication of values within a nonprofit arts context via a range of channels, including traditional, online and multi-sensory, is sparse. The opportunity to study a newly formed nonprofit arts organisation is also rare. The results of this study provide valuable evidence that even in today’s social media-rich world, people, sounds, sights and material objects in physical space still have a vital role to play in the communication of values.
Cognitive micro-foundations at work: how organizations resist change in work practice
Authors: Malmstrom Malin 
Published: September 2016

Purpose
The purpose of this paper is to explore the essence that is, the nature of organizational responses to efficiently resist enforced change in institutionalized work practice destined to address poor organizational performance. The micro-foundations of the cognitive logic that are activated when organizations face change are hereby conceptualized.

Design/methodology/approach
Using a case study design, the study focusses on narratives of a failure to implement a regulatory enforced change in work practice at a military academy established in the 1600s. The interviews are complemented by secondary data.

Findings
The analysis reveals a cognitive framework by which the members of the organization shaped their responses. By building on micro-foundations for mobilizing resistance (i.e. the essential substance at a micro level), this study shows how the cognitive logic is activated to respond to change. To show how the cognitive logic is used to mitigate and compensate for incongruences with the regulatory logic, this study outlines a set of strategic resistance maneuvers and cognitive resistance forces that restrict regulatory influence on change in work practice. This study thus provides insights into maneuvers and resistance forces that members may activate to resist change efficiently.

Originality/value
To the author’s knowledge, this is the first study to attempt to conceptualize the essence of the cognitive logic activated to resist organizational change.
Preserving prerequisites for innovation
Authors: Olander Heidi , Vanhala Mika , Hurmelinna-Laukkanen Pia , Blomqvist Kirsimarja 
Published: September 2016

PurposeThe purpose of this paper is to study how the motivation in firms to safeguard the prerequisites of innovation relates to the strength of the employee-related protection mechanisms that deal with knowledge leaking and knowledge leaving, and the moderating effect of organizational trust in the relationship.Design/methodology/approachThe hypotheses were tested on a sample collected in Finland from 80 companies engaged in R&D. A partial least squares was used for the analyses.FindingsKnowledge leaking and leaving from a firm can be approached with both formalized and soft types of employee-related mechanisms; that the motivation to secure innovativeness positively relates to both forms; and that the presence of organizational trust is especially effective in reinforcing employee-related practices that can prevent knowledge leaving.Research limitations/implicationsThe data were gathered in a single western European country and that may have affected the results.Practical implicationsThe managers would do well to introduce both formalized and soft forms of protection so as to mitigate the effects of knowledge both leaving and leaking. Building on the findings of this study, managers could prioritize between the different categories and mechanisms depending on the market and industry they operate in.Originality/valueThis study adds to the literature by studying quantitatively the employee-related protection mechanisms and the effect of organizational trust in the usage of those mechanisms.
Examining the linkage between creative self-efficacy and work engagement
Authors: Chen I-Shuo 
Published: September 2016

PurposeThe purpose of this paper is to examine the relationship between creative self-efficacy and work engagement using openness to experience as a moderator. The theoretical background is rooted in the resource perspective of the job demands-resources model (JD-R model) of work engagement.Design/methodology/approachThe developed hypotheses were tested in a study of 101 faculty members from a science and technology institute in the USA. Hierarchical regression analysis was used to analyze the data.FindingsThe results supported a positive effect of creative self-efficacy on work engagement but did not support a moderating effect of openness to experience on the relationship between creative self-efficacy and work engagement.Originality/valueThis study introduces the context of creativity into the work engagement and JD-R model fields. Specifically, through the resource perspective of the JD-R model, it theoretically and empirically extends the contribution and explanatory ability of personal resources to the improvement of work engagement.
Biotech spin-off business models for the internationalization strategy
Authors: Bialek-Jaworska Anna , Gabryelczyk Renata 
Published: September 2016

PurposeThe purpose of this paper is to identify the business model components and related attributes of biotech spin-offs activity that are key to the implementation of the internationalization strategy.Design/methodology/approachThe paper is based on a multiple case study analysis including business models of seven biotechnology spin-offs traded on the Warsaw Stock Exchange. Based on the literature review the authors identify the key attributes of the business model for the commercialization of R&D outcomes. The authors conduct an analysis taking into consideration the determinants of biotech spin-off activity. The authors also measure the internationalization strategy implementation with the use of indicators identified in the empirical research literature review.FindingsAccording to the results, the authors identified that international cooperation in research projects and partnering, as well as international experience in the management board and tacit knowledge, play a facilitating role in the business model for the commercialization of biotech spin-off research findings. The cost advantage on the global market, tax advantages and support of venture capital are the key to the exploitation of profit potential on the global market. An important component of the business model specific to companies conducting R&D activities is to ensure firm survival activities by funding research grants to makes R&D possible prior to commercialization.Research limitations/implicationsThe main limitation of this study is the small magnitude of the sample, particularly as only two of the seven analyzed spin-offs realized their profit potential on the global market.Practical implicationsThe findings are important for the development of business models of new biotech ventures. Research results can be used as recommendations for universities on how to effectively build a business model for the commercialization of biotech spin-offs on the basis of R&D outcomes for the internationalization strategy.Originality/valueThe paper’s uniqueness results from the synergy of combining three research areas: components of business models for commercialization; attributes of biotech R&D activity; and indicators measuring the internationalization strategy implementation. The results can contribute to the existing body of knowledge on business models for the commercialization of R&D outcomes in the context of internationalization. The value of this paper is an extended knowledge of the internationalization of biotech ventures based on R&D outcomes.
Simulation on polytropic process of air springs
Authors: Li Xuebing , Wei Yintao , He Yuan 
Published: September 2016

Purpose
The purpose of this paper is to propose a method to simulate the polytropic process of air springs.

Design/methodology/approach
An iterative finite element method (FEM) is proposed.

Findings
The proposed method is reliable and effective in solving the polytropic process of air springs.

Originality/value
This work would be helpful for understanding the simulation of pneumatic structures, and the proposed modified FEM would be useful for improving the simulation of the mechanical behavior of an air spring.
The moderating role of information technology capability in the relationship between supply chain collaboration and organizational responsiveness
Authors: Cai Zhao , Huang Qian , Liu Hefu , Liang Liang 
Published: September 2016

PurposeThe purpose of this paper is to propose a model to test the relationship between supply chain collaboration (SCC) and organizational responsiveness. Three types of information technology (IT) capability are considered as moderators in this relationship.Design/methodology/approachThe study conducted a questionnaire survey of 208 firms from various industries in China. Hierarchical regression analysis was used to test the hypotheses.FindingsSCC positively affects organizational responsiveness. Both outside-in and spanning IT capability positively moderates this relationship, whereas inside-out IT capability has a negative moderating effect on this relationship.Originality/valueThis research extends the knowledge regarding the value creation process of SCC from an organizational learning perspective. The study explores the moderating roles of three types of IT capability in this process and further clarifies the relationship between SCC and organizational responsiveness.