bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analisis Pengaruh Perubahan Tutupan Lahan Terhadap Ancaman Bencana Longsor Dengan Menggunakan Sistem Informasi Geografis (Studi Kasus: Kabupaten Kebumen)
Authors: Hanifudin Faiz , Nugraha Arief Laila , Firdaus Hana Sugiastu 
Published: October 2024

Bencana longsor merupakan bencana yang paling sering terjadi di Kabupaten Kebumen. Berdasarkan data BNPB tercatat pada tahun 2014 hingga 2023 terdapat 400 bencana, 193 diantaranya merupakan bencana tanah longsor. Pada penelitian ini dilakukan pemetaan ancaman bencana tanah longsor pada tahun 2016 dan 2022 serta dilakukan analisis terkait perubahan tutupan lahan yang paling mempengaruhi terhadap bencana longsor. Pembuatan peta ancaman mengacu pada Permen PU No.22/PRT/M/2007 dengan enam parameter yaitu kemiringan lereng, curah hujan, kedekatan sesar, jenis tanah, jenis batuan, dan tutupan lahan. Pembobotan parameter menggunakan metode Analytical Hierarchy Process (AHP) serta analisis pengaruh perubahan tutupan lahan menggunakan metode Frequency ratio (FR). Berdasarkan hasil penelitian didapatkan bahwa bencana longsor di Kabupaten Kebumen tahun 2016 dan 2022 tidak memiliki perubahan signifikan, untuk ancaman longsor didominasi oleh kelas rendah berkisar 73%, kelas sedang 24%, kelas 3%, dan yang terakhir kelas sangat tinggi 0%. Untuk analisis pengaruh perubahan terhadap ancaman longsor, perubahan tutupan lahan menjadi lahan kosong merupakan perubahan tutupan lahan yang mempunyai pengaruh paling besar terhadap ancaman bencana longsor. Sedangkan perubahan tutupan lahan menjadi hutan merupakan perubahan tutupan lahan yang paling kecil pengaruhnya terhadap ancaman tanah longsor, hal ini dibuktikan dengan nilai FR lebih dari 1 dan cenderung lebih besar dari tutupan lahan lainnya.
Phylogenomic analysis of glutamine synthetase gene family in Helianthus annuus L.
Authors: Singh Vrinda , Kumar Vivek , Razaq Mohd , Jain Pooja , Teotia Deepti , Agrawal Aman , Bhardwaj Mukesh Kumar , Sharma Hemant , Malik Pranita , Kumar Sachin , Malik Vijai 
Published: October 2024

Glutamine synthetase is one of the predominant enzymes in nitrogen metabolism. In developing leaves, glutamine is mainly produced in chloroplasts by the activity of the GS2 isoenzyme. It catalyzes glutamine synthesis from glutamate and ammonia in an ATP-dependent reaction. The genes encoding glutamine synthetase play a crucial role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. The gene family responsible for producing glutamine synthetase has been previously documented in model plants like Arabidopsis. Nevertheless, there has been no exploration into its existence and attributes in oilseed crops like sunflower (Helianthus annuus L.). This study thoroughly analyzes, gene structure, conserved motifs, chromosomal location, phylogenetic relationships, and expression patterns to identify the glutamine synthetase genes in H. annuus. Our findings unveiled 19 genes encoding glutamine synthetase within the H. annuus genome. These genes were distributed across 11 chromosomes of H. annuus. Furthermore, we examined the expression patterns of all the HaGS genes using RNA-seq datasets, specifically focusing on their response to biotic and abiotic stress conditions. Under biotic stress, H. annuus expresses genes for mycorrhizal fungi named Rhizoglomus irregulare at four days post inflorescence (dpi) and 16 dpi. Under abiotic stress, the effect of drought and hormones was investigated. In drought, one gene, HaGS6D, showed the highest expression in the leaf. Meanwhile, in roots, gene HaGS7B showed the highest expression. Under hormonal stress, the effects of auxin, brassinosteroid, and cytokinin were studied on the leaf. For auxin, the gene HaGS7C showed the highest expression. For brassinosteroid, the gene HaGS7D showed the highest expression; for cytokinin, the gene HaGS6E showed the highest expression. Thus, these findings can significantly contribute to our understanding of the arrangement of glutamine synthetase genes in H. annuus and offer valuable insights for developing of drought-resistant cultivars of this species.
The protective effect of angiotensin II type I receptor blocker (valsartan) on behavioral impairment, NLRP3, BDNF, and oxidative stress in the brain tissue of ovariectomized female rats
Authors: Erdem Salih , Özaçmak Hale Sayan , Turan İnci , Ergenç Meryem 
Published: October 2024

AbstractDepression and anxiety are common mental health disorders affecting thoughts, behaviors, and emotions. This study aimed to investigate the effect of the angiotensin II type I receptor blocker (AT1RB), valsartan, on menopause‐induced depression and anxiety‐like behaviors, and to elucidate possible mechanisms of action by measuring levels of nod‐like receptor protein 3 (NLRP3), interleukin‐1beta (IL‐1β), brain‐derived neurotrophic factor (BDNF), and oxidative stress in brain tissue. Thirty‐two Wistar albino female rats were randomly divided into four groups (n = 8 per group): Control, AT1RB, OVX, and AT1RB + OVX. Following the bilateral ovariectomy (OVX) protocol, physiological saline was used as valsartan solvent, in a maximum volume of 0.4 mL, and valsartan was administered via intragastric gavage at a dose of 40 mg/kg/day. Depression and anxiety‐like behaviors were assessed using the forced swimming test and open field test. Levels of oxidative stress markers, NLRP3, IL‐1β, BDNF, and CREB were analyzed in the hippocampus and prefrontal cortex tissues. Behavioral tests indicated that depression and anxiety‐like behaviors significantly increased in OVX rats (p < 0.01), while AT1RB treatment significantly reduced these behaviors (p < 0.05). In the hippocampus of OVX rats, oxidative stress (p < 0.01), NLRP3 (p < 0.05), and IL‐1β (p < 0.01) levels were elevated, whereas BDNF levels were significantly decreased (p < 0.01). AT1RB treatment significantly improved oxidative stress parameters (p < 0.05) and BDNF levels (p < 0.01) but did not significantly affect the increased levels of NLRP3 and IL‐1β in OVX rats. In conclusion, AT1RB has a therapeutic effect on menopause‐induced depression and anxiety‐like behaviors, likely by reducing oxidative stress and increasing BDNF production in the hippocampus.
The Law of Finding Lost Movable Property in England, Germany and Scotland
Authors: Lusznat Leonard 
Published: October 2024

Abstract
The law of finding lost movable property is not only a practically significant but also doctrinally fascinating topic, which has, however, only rarely been treated comparatively. Therefore, the article analyses to what extent a common core exists between a civil law (Germany), mixed (Scotland) and common law (England) legal system and whether the three jurisdictions achieve the purposes of the law of finding. In light of the scarcity of legal literature, the article is the first detailed treatment of the subject in Scots law. It does not only demonstrate that the common core between all three jurisdictions is remarkably small but also that German and Scots law are notably similar, while English law generally takes the opposite legal approach, indicating that Scots law is more related to civil than common law in this field. Moreover, in contrast to both Germany and Scotland, England does, because of the disadvantageous legal position of the finder, not accomplish the purposes of the law of finding; that is, neither (primarily) restoring possession of lost property to its owner nor (secondarily) freeing the finder from the burden of safekeeping found property for the owner. Consequently, legislative reform of English law is indicated.
Performance evaluation of fly ash-lime-gypsum-quarry dust (FALGQ) bricks for sustainable construction
Authors: Sankar Pramod , Ravi Kumar Muthuswamy Saraswathi 
Published: October 2024

Abstract
The aim of this study is to optimize fly ash utilization by combining lime, gypsum, and quarry dust in various proportions to develop fly ash lime gypsum quarry dust (FLGQ) bricks with dimensions of 230 mm × 110 mm × 70 mm, as a potential alternative to traditional bricks. The investigation analysed the compressive strength, split tensile strength, water absorption, density, and initial rate of absorption of FLGQ bricks across different mixes. Mix 9 (M9), comprising of 35% fly ash, 10% lime, 25% gypsum, and 30% quarry dust, exhibited a 15% higher compressive strength (7.2 MPa) and 12% higher split tensile strength (0.85 MPa) compared to the superior conventional brick. Water absorption for M9 was reduced by 18%, enhancing the durability. Prediction models for compressive and split tensile strengths were developed using regression analysis, achieving over 92% accuracy when compared to experimental data at 28 and 56 days. Additionally, a positive correlation was observed between the 14th, 28th, and 56th days results, reinforcing the reliability of predictions in brick compressive strength. These research findings indicate that M9 is superior and more sustainable alternative to traditional bricks, with significant improvements in key performance metrics.
Trauerversorgung in Deutschland. Expert/-inneninterviews zu historischen und aktuellen Entwicklungen
Authors: Müller Heidi , Berthold Daniel , Kohlhaas Anna-Marie , Wleklinski Oliver , Zwingmann Christian 
Published: October 2024

Zusammenfassung
Es liegen kaum systematisierte Erkenntnisse über die Anfänge und die historische Entwicklung der Trauerversorgung in Deutschland vor. Ziel dieser Studie ist es, mehr über die historische Entwicklung der Trauerversorgung in Deutschland zu erfahren und Verbindungen zwischen Historie und aktueller Versorgungssituation aufzuzeigen, um so die Zukunft besser gestalten zu können.
An dieser explorativen Studie nahmen elf Expert/-innen aus dem Feld der Trauerversorgung teil. Die Befragung erfolgte anhand teilstrukturierter Interviews. Die Antworten wurden in einem deduktiv-induktiven Prozess inhaltsanalytisch ausgewertet.
Die Auswertung zeigt, dass der Aufbau der Trauerversorgung in Deutschland nicht systematisch, sondern getragen durch Einzelinitiativen aus dem kirchlichen und hospizlichen Bereich, der Palliativmedizin sowie der AIDS-Bewegung erfolgte. Bereits vorliegende wissenschaftliche Erkenntnisse vor allem aus dem angloamerikanischen Bereich fanden dabei wenig Beachtung. Heute besteht eine grundsätzliche Offenheit in der Gesellschaft, über das Thema Trauer zu sprechen. Die Versorgung befindet sich derzeit in einem Prozess der Professionalisierung.
Das Feld der Trauerversorgung in Deutschland weist große Heterogenität, fehlende Steuerungsstrukturen, Mängel im Qualitätsmanagement sowie offene Fragen hinsichtlich einer bedarfsgerechten Versorgung auf. Der aktuelle Zustand ist wenigstens teilweise durch die Anfänge und historische Entwicklung der Trauerversorgung erklärbar. Es werden Schlussfolgerungen und Vorschläge für die zukünftige Entwicklung skizziert.
Benefits of reducing duration of endoscopic duodenal-jejunal bypass liner implantation to nine months in treatment of diabesity
Authors: Ryder Robert E J , Yadagiri Mahi , Day Caroline , Burbridge Wyn , Irwin Susan P , Gandhi Hardeep , Bashir Tahira , Allden Rachael A , Wyres Melanie , Cull Melissa , Bleasdale John P , Fogden Edward N , Anderson Mark R , Sen Gupta Piya 
Published: October 2024

Aims: To assess the safety and efficacy of duodenal-jejunal bypass liner (DJBL) implantation for 9 months or 12 months in patients with obesity and sub-optomally controlled type 2 diabetes (T2DM).
Methods: Over 4.25 years DJBLs were implanted in 90 adult patients with obesity and sub-optimally controlled T2DM at a single centre in England. The liners remained in situ for up to 12 months and outcomes were monitored in a registry.
Results: Of the 90 patients (BMI 41.5±7.1kg/m2, HbA1c 79.3±20 mmol/mol), 53% were insulin-treated. During DJBL treatment, there was no difference between the mean±SD fall in HbA1c at 9 months (20.5±18.8mmol/mol) vs. 12 months (20.5±19.4mmol/mol) (p=0.95). The mean±SD weight loss at
9 months (13.8±7.7kg) was 1.6±3.6kg less than that at 12 months (15.4±8.4kg) (p<0.001). By 12 months, 15.6% of patients had had early DJBL removal due to serious adverse events (SAEs), from which they all recovered. Of these SAEs, 43% would have been avoided by DJBL removal at 9 months. Conclusion: DJBL is effective in people with intractable diabesity. To reduce the incidence of SAEs, our data support reducing the recommended/conventional implantation period for DJBL from 12 months to 9 months.
MCM9 compound heterozygosity in an adolescent with premature ovarian insufficiency
Authors: Nauwynck Elise , De Vos Michel , Gheldof Alexander , Dequeker Bart JH , Van Der Kelen Annelore , Hes Frederik , Verheyden Stephanie , Vanbesien Jesse , Gies Inge , De Schepper Jean , Staels Willem 
Published: October 2024

Summary
Delayed puberty in girls is often related to late maturation but is occasionally the first sign of premature ovarian insufficiency (POI). POI is a condition that affects ovarian function and fertility, and its etiology is unknown in most cases. Genetic factors have recently been identified in 20–25% of women with POI, involving genes that regulate various aspects of ovarian development and maintenance. We report a case of delayed puberty due to POI in an adolescent from a non-consanguineous family who carried two variants in the MCM9 gene. MCM9 is essential for DNA replication and repair, and its dysfunction can lead to chromosomal instability and ovarian failure. Our case highlights the importance of targeted gene panel analysis, particularly in POI patients with negative autoimmunity screening, and evidence of ovarian or uterine dysgenesis on pelvic imaging.

Learning points

Delayed puberty in girls is often self-limiting, but it can also indicate underlying conditions with lifelong implications, such as premature ovarian insufficiency (POI).

Patients with POI, negative autoimmune screening, a normal karyotype, and no FMR premutation should undergo further genetic testing, preferably through targeted gene panels.

Compound heterozygous variants in MCM9 can cause POI, presenting with delayed puberty and primary amenorrhea in girls without a consanguineous family.
Support-verb constructions with carere ‘to be free (from)’ in the LatinISE corpus: The caritive in Latin
Authors: Fendel Victoria Beatrix 
Published: October 2024

AbstractSupport-verb constructions are combinations of a verb and a noun that fill the predicate slot of a sentence, as to make a suggestion in he made the suggestion that she join us. The article investigates whether carere ‘to be free from’ (+ ablative), unlike egere and indigere, in support-verb constructions, such as dolore careo ‘to be free from pain’, moves from lexical-phraseological to grammatical-analytical between the classical and post-classical periods, based on (i) the contiguity of components, (ii) the degree of component compatibility, and (iii) the spread across authors. The article argues that the classical verb of realisation becomes a support verb in post-classical times. The classical verb of realisation qualifies as a Caritive functioning as a low-scope scalar focus negative; the post-classical support verb seems to be semantically broader. Carere ‘to be free from’ never becomes an auxiliary verb but hovers at the syntax-lexicon interface throughout.
ESTRATÉGIAS DE GESTÃO DE RESÍDUOS SÓLIDOS URBANOS: UMA REVISÃO SISTEMÁTICA
Authors: Azevedo Marcela Evelyn Paiva de , Lebre Alexandre Pilad , Júnior Fernando Richard Lima Perez , Ataíde Tatiane Pessoa de , Silva Cristiano da , Meira Dulce Mara , Nagalli André 
Published: October 2024

A preocupação global com a gestão sustentável de resíduos está crescendo devido aos impactos ambientais adversos e às regulamentações cada vez mais rigorosas. No entanto, muitas estratégias atuais de gestão de resíduos focam apenas em aspectos específicos como tratamento, conformidade legal ou eficiência operacional, deixando lacunas significativas no processo geral. O objetivo deste estudo foi realizar uma revisão sistemática da literatura para compreender as diferentes estratégias de gerenciamento de resíduos sólidos urbanos disponíveis em termos de impacto ambiental, econômico e social, e como a eficiência dessas estratégias pode ser avaliada e aprimorada para promover práticas mais sustentáveis nas áreas urbanas. A revisão incluiu estudos recentes e artigos relevantes publicados entre 2020 e 2024, com foco em pesquisas no Brasil e internacionalmente indexadas na Web of Science. Os resultados destacam a aplicação diversificada de metodologias e tecnologias, especialmente modelos de Rede Neural Artificial para previsão de resíduos, técnicas multicritério e análises estatísticas para a otimização de sistemas de gerenciamento, todos mostrando potencial. A literatura ressalta a importância de adaptar as estratégias de gerenciamento de resíduos às especificidades regionais. A implementação de estratégias sustentáveis é crucial para enfrentar os desafios ambientais e sociais decorrentes da geração e disposição de resíduos sólidos urbanos, fomentando um futuro mais sustentável e resistente.
An analysis of drug approvals in India over past 5 years
Authors: Shaikh Aarmin I. , Acharya Chetankumar R. , Shah Akash M. , Moradiya Manan G. , Patel Jay R. , Patel Aayushi H. , Bhanderi Mehul V. 
Published: October 2024

Background: Drug development is a tedious process and takes a long time for approval by regulatory authorities. With time, Indian authorities have revised rules and regulations for conducting clinical trials as well as for the marketing of drugs, impacting the number of drugs being approved.
Method: The information about drug approvals from 2019–2023 was obtained from the CDSCO website. The single drug products were classified into 14 main anatomical therapeutic chemical (ATC) groups, while Fixed Dose Combinations (FDCs) were classified based on the system they act upon. Descriptive statistical analysis was done. The findings of our observational study were expressed as absolute numbers and percentages.
Results: Total 362 drugs were approved. Out of these, 135 were single drug products, and the rest were FDCs. The highest & lowest number of drugs were approved in the year 2022 and 2019 respectively. Maximum single drug product approvals were seen in Category L-antineoplastic and immunomodulating agents, while maximum FDC approvals were for drugs acting on the endocrine system.
Conclusion: There is a rising trend of approval for FDCs. The pattern of single drug products approval flattened over the years, coinciding with the implementation of new rules and regulations.
Histopathological features of prostatic carcinoma in a Southwest tertiary institution in Nigeria
Authors: Ayo-Aderibigbe Olabisi , Sabageh Donatus , Odujoko Oluwole Olaniyi , Adekunle Adebayo Ayoade 
Published: October 2024

Background: The diagnosis of prostatic adenocarcinoma is often straightforward, in some cases there may be benign lesions that mimic prostatic cancer histologically. This study aimed to describe the morphological features of prostatic carcinoma from laboratory specimens.
Methods: This was a retrospective study using histologically diagnosed cases of prostatic carcinoma from prostatectomy and trucut biopsy specimens. The histological sub-typing of the tumors according to WHO classification scheme of 2003 was done. The tumors were graded and scored using Gleason’s scoring scheme revised and modified at the consensus conference of the international society of urological pathology (ISUP), in 2005.
Results: Prostate cancer constituted 18.7% of all malignant tumors and 4.4% of all neoplastic diseases. The majority of cases were small acinar adenocarcinoma 275 (73.7%). Others include pseudo-hyperplastic variant 47 (12.6%), atrophic variant 35 (9.3%), foamy gland carcinoma 16 (4.2%) and signet ring/colloid carcinoma 1(0.2%). More than half were classified as well-differentiated Gleason prognostic group A tumors. There was a statistically significant association between the age of the patient and the Gleason histologic grade and the histologic grade and histologic variant p<0.05.
Conclusions: Prostatic carcinoma was thought to be a malignancy associated with elderly men but people of younger age less than fifty years are now diagnosed with the malignancy. Accurate diagnosis with the right grade and scores will go a long way in the management of the malignancy.
Exploring the Application of ISSM and TTF Theories: A Literature Review
Authors: Jebril Hend Ali Musbah , Mohamad Ummul Hanan , Ahmad Mohammad Nazir 
Published: October 2024

The Information System Success Model (ISSM) and Task-Technology Fit (TTF) theories provide valuable frameworks for assessing how effectively technology supports tasks within a system. These models are widely recognized and have been applied separately in numerous studies. However, there has been limited effort in the existing literature to integrate ISSM and TTF into a cohesive framework. This study aims to (1) review the relevant literature applying ISSM and TTF in higher education settings, (2) determine which model is more frequently utilized, and (3) evaluate studies that have integrated both models, with a particular focus on digital libraries. The results indicate that most research has centered on theory development or practical real-world applications, especially in public universities. The integration of ISSM and TTF in digital library contexts remains relatively rare despite their potential to complement one another. ISSM assesses system success through dimensions like service quality, user satisfaction, and net benefits, while TTF focuses on how well the technology fits the tasks it is intended to support, making it highly relevant for evaluating digital services. This study contributes to a deeper understanding of how ISSM and TTF are applied, offering valuable insights for future research. It highlights the untapped potential of combining these models to enhance technology adoption, user satisfaction, and overall system performance in digital libraries and other educational settings. By identifying research gaps, this paper lays the groundwork for further exploration and refinement of these theoretical frameworks to improve technology implementation in education.
Prevalence, Correlates, and Impacts of Displacement Because of Natural Disasters in the United States From 2022 to 2023
Authors: Aung Ther W. , Sehgal Ashwini R. 
Published: October 2024

Objectives. To quantify the prevalence, correlates, and impacts of displacement because of natural disasters in the United States. Methods. We pooled data across 10 independent survey samples from the Census Bureau Household Pulse Survey from December 2022 to September 2023. Survey questions asked about displacement from home because of natural disasters, duration of displacement, and impacts of disasters. Results. In our weighted sample of 213 234 003 adults, 3 166 500 (1.5%) reported displacement in the past year because of a natural disaster. People of color, sexual and gender minority populations, and those with lower incomes, disabilities, or unfavorable social determinants of health (SDOH) such as food insecurity were more likely to report displacement. Long-term displacement was more common with fires compared with other disasters. Disaster impacts, including food and water shortage, electricity loss, unsanitary conditions, feeling isolated, and experiencing scams, were more common among people of color and individuals with lower education or income. Conclusions. Many people in the United States, particularly from health disparity populations, are displaced because of natural disasters. Addressing SDOH and other vulnerability factors may help improve disaster preparedness and mitigate postdisaster impacts. ( Am J Public Health. 2025;115(1):55–65. https://doi.org/10.2105/AJPH.2024.307854 )