bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anemia in Pregnancy and Its Maternal Perinatal Outcome
Authors: Indra Putra Iriawan , Joice Margaretha Mathilda Sondakh  , Juneke Joice Kaeng  
Published: September 2024

Objective: To investigate the relationship between anemia in pregnancy and maternal perinatal outcomes.
Methods: This was a retrospective cohort study. This research was held at Prof. Dr. R. D. Kandou General Hospital Manado. Data was taken from January 2021 to December 2022.
Results: There were 1953 deliveries which 1304 subjects (66.7%) with anemia 649 subjects with anemia (33.3%), 489 subjects with mild anemia, and 160 subjects with moderate-severe anemia. The median maternal age was 28 years for mild anemia. The majority of mothers have a high school education. A total of 326 study subjects were multigravidas with mild anemia. The results of severe preeclampsia with mild anemia were 30 subjects. Prolonged labor tends to be higher in the mild anemia group. The highest distribution was observed in the mild anemia group, with 12 cases of maternal mortality, 88 cases of premature birth, 78 cases of low birth weight (LBW), 75 cases of disorders leading to decreased scores, and 24 cases of fetal mortality. In research subjects, IUGR tends to be more common in groups with moderate-severe anemia with 14 subjects (8.8%). Hemoglobin levels showed a median of 11.6 g/dL with a distribution midway between 10.5 and 12.6 g/dL. The mean MCV value is 76.1 fL (SD 8 fL). The mean MCH value was 24.8 + 3.6 pg. The MCHC value is 32.5%. Conclusions: There are no significant relation in pregnant women with anemia with preeclampsia, prolonged labor, maternal mortality rate and IUGR, but there are significant relation between anemia in pregnancy with increase rate of caesarean section, premature delivery, low birth weight, low APGAR score and fetal death.
Keywords: anemia in pregnancy, maternal outcome, neonatal outcome
Retroalimentación y evaluación en el rendimiento académico en estudiantes de primaria: un estudio bibliométrico de Scopus
Authors: Salazar del Aguila Bernarda , Romero-Carazas Rafael 
Published: September 2024

El presente estudio tuvo como objetivo analizar la bibliometría en Scopus sobre la retroalimentación y evaluación en el rendimiento académico en estudiantes de primaria, entre los años 2003 y 2023. Se trató de un estudio bibliométrico que definió las métricas de la producción científica. Los indicadores se obtuvieron a partir de 370 documentos elegidos de la base de datos Scopus utilizando palabras clave en inglés (feedback, assessment, Academic achievement, elementary school students). Los resultados muestran que el periodo de mayor producción científica fue de 2017-2022 (n=192; 51.9%). Además, Estados Unidos (35.2%; n=147) es el país con más publicaciones, mientras que la revista Medical Teacher publicó 7 documentos y obtuvo más citas (226), siendo el autor Witt, J.C. el más citados (369 citas; n= 3 documentos). En conclusión, la retroalimentación y evaluación del rendimiento académico de los estudiantes de primaria ha aumentado la disponibilidad de recursos y la diversidad de temas y autores, debido a que la retroalimentación y la evaluación mejoran el rendimiento académico al ayudar a los estudiantes.
Pelatihan dan Pendampingan Kelompok Tani dalam Mengolah Limbah Pertanian Menjadi Ekoenzim di Kelurahan Bukit Tunggal
Authors: Saefulloh Ahmad , Agustiani Reni , Elsandika Gabriela , Telaumbanua Julius , Tabang Valentino , Khairi Khairi , Fitriani Fitriani 
Published: September 2024

Kegiatan pertanian di Kelurahan Bukit Tunggal menghasilkan sisa sayur dan buah yang belum dimanfaatkan secara optimal. Biasanya sisa-sisa tersebut hanya dibiarkan membusuk ditumpuk di suatu tempat. Tim memandang permasalahan ini harus diselesaikan, supaya tidak menambah dampak buruk pada lingkungan dengan adanya gas metana. Oleh sebab itu, tim memberikan pelatihan dan pendampingan kelompok tani dalam mengolah limbah pertanian menjadi ekoenzim. Metode yang tim gunakan dalam pelaksanaan kegiatan PkM mengacu pada 4 tahapan yaitu persiapan, sosialisasi program, pelatihan dan pendampingan, serta evaluasi. Hasil kegiatan pelatihan dan pendampingan menunjukkan antusiasme 35 peserta yang berasal dari seluruh kelompok tani di kelurahan Jekan Raya. Kegiatan ini dipandang berhasil dengan tolak ukur pre test dan post tes yang tim lakukan. Hanya terdapat 25% peserta pelatihan yang mengetahui ekoenzim pada saat prestes, namun setelah kegiatan pelatihan pemahaman peserta meningkat menjadi 90% terhadap pembuatan ekoenzim.
Peningkatan Efisiensi Dan Mutu Packaging Melalui Pemanfaatan Continuous Band Sealer Pada UMKM Rengginang
Authors: Ilhami Susanti Dwi , Puryono Daniel Alfa , Damayanti Damayanti 
Published: September 2024

Rengginang merupakan salah satu produk unggulan Kabupaten Rembang. Salah satu kecamatan yang memproduksi rengginang yakni kecamatan Banggi. Permasalahan yang dihadapi yakni kemasan regginang rentan mengalami kebocoran sehingga kualitas produk menurun. Selain itu, proses sealing yang telah dilakukan membutuhkan waktu yang lama sehingga kurang efisien pada saat terjadi lonjakan permintaan. Oleh karena itu dibutuhkan teknologi guna meningkatkan efisiensi dan mutu kemasan produk rengginang sehingga kepuasan konsumen meningkat. Kegiatan pengabdian bertujuan guna menghasilkan kemasan rengginang yang memiliki kualitas tinggi dan efisiensi waktu. Tahapan kegiatan pengabdian mencakup, perencanaan, pelaksanaan, dan evaluasi. Hasil dari pelaksanaan kegiatan pengabdian sealing pada kemasan lebih rapat sehingga mutu kemasan bisa lebih baik dan tidak rentan bocor. Selan itu, dalam proses sealing per kemasan hanya membutuhkan waktu 11 detik sehingga efisiensi waktu jauh lebih baik. Kemasan yang bocor hanya 1-2 kemasan per 100 kemasan yang dibuat. Hal ini mendorong peningkatan kepuasan konsumen berkaitan dengan kemasan rengginang.
Spatiotemporal variation of alpine gorge watershed landscape patterns via multi-scale metrics and optimal granularity analysis: a case study of Lushui City in Yunnan Province, China
Authors: Wang Yongshu , Yan Xiangdong , Fang Qingping , Wang Lan , Chen Dongbo , Yu Zhexiu 
Published: September 2024

IntroductionThe selection of an optimal scale or granularity in landscape analysis is pivotal for uncovering inherent patterns and changes driven by processes. Variations in spatial resolution can significantly alter the proportions and distributions of various landscape types, thereby impacting the assessment of landscape patterns. Despite its importance, the scale factor is frequently neglected in studies focusing on long-term landscape dynamics.MethodsBridging this gap, we utilized remote sensing imagery data from 1986 to 2020 for Lushui City, integrating remote sensing (RS) and geographic information system (GIS) technologies to generate land cover maps. Our focus centered on investigating the sensitivity of landscape pattern indices within the 30–1000m scale. Combining the first scale domain with an information loss assessment model, we identified the optimal granularity for the analysis, conducting a detailed spatiotemporal examination of landscape pattern from 1986 to 2020 using the index analysis method.Results and discussionThe results show that: (1) The dominance of forests in Lushui City, yet reveal a significant increase in construction land area over the study period, primarily driven by the conversion of forest and grassland. (2) Among the 10 examined indices, four (PD, ED, TE, and LSI) demonstrated predictable responses to changes in granularity, while three (PAFEAC, COHESION, AI) exhibited unpredictable stepwise reactions. Three indices (LPI, SHDI, PLAND) displayed minimal regularity to granularity changes. (3) The optimal long-term landscape analysis granularity for Lushui was identified as 100 m. (4) Before 1996, the city’s landscape exhibited characteristics of aggregation, good connectivity, and minimal anthropogenic disturbance. However, post-1996, the landscape experienced disruptions, leading to an overall increase in fragmentation. The expansion of cultivated land and construction land due to urbanization has intensified landscape fragmentation. However, policies such as converting cropland to forest and planned ecological civilization initiatives have restored forest coverage and improved landscape cohesion and connectivity in Lushui City. This research offers vital insights for ecological planning and resource management in alpine valley watershed cities, deepening our grasp of landscape pattern evolution.
A method for simultaneously measuring friction and gap at metal–lubricant interface by combined use of atomic force microscopy and line-and-space patterned metal films
Authors: Yamashita Naoki , Hirayama Tomoko 
Published: September 2024

In boundary lubrication, adsorbed molecular films formed by lubricant additives on the metal surfaces of sliding parts effectively reduce friction and wear. A method is presented for simultaneously measuring friction and the gap at a metal–lubricant interface under boundary lubrication conditions using atomic force microscopy. In this method, line-and-space patterns are microfabricated in Cu films on Si substrates, and the gap is evaluated from the step height change when scanning in base oil and in base oil with an additive. Neutron reflectometry showed that whereas both stearic acid and stearyl alcohol formed molecular film about 2 nm thick on Cu film in a static state, the gap increased only with stearic acid due to maintaining a molecular film on the Cu film. This demonstrates the feasibility of the proposed method as means for visualizing the gap and shows that there is a difference between the two additives in their film-forming ability in a static state and their durability against friction. The proposed method for simultaneously measuring friction and the gap at a metal–lubricant interface is thus an effective way to investigate the tribological performance of additives under boundary lubrication conditions.
Conditional survival and changing risk profile in patients with gliosarcoma
Authors: Xu Lei , Yang Zhihao , Chen Huawei , Sun Chengjun , Tu Chuanjian , Gu Zhiwei , Luo Ming 
Published: September 2024

BackgroundConditional survival (CS) considers the duration since the initial diagnosis and can provide supplementary informative insights. Our objective was to evaluate CS among gliosarcoma (GSM) patients and develop a CS-incorporated nomogram to predict the conditional probability of survival.MethodsThis retrospective study using the Surveillance, Epidemiology, and End Results (SEER) database included patients with GSM between 2000 and 2017. The CS was defined as the probability of surviving additional y years after already surviving for x years. The formula utilized for CS was: CS(y|x) = S(y + x)/S(x), where S(x) denotes the overall survival at x years. Univariate Cox regression, best subset regression (BSR) and the least absolute shrinkage and selection operator (LASSO) were used for significant prognostic factors screening. Following this, backward stepwise multivariable Cox regression was utilized to refine predictor selection. Finally, a novel CS-integrated nomogram model was developed and we also employed diverse evaluation methods to assess its performance.ResultsThis study included a total of 1,015 GSM patients, comprising 710 patients in training cohort and 305 patients in validation cohort. CS analysis indicated a gradual increase in the probability of achieving a 5-year survival, ascending from 5% at diagnosis to 13, 31, 56, and 74% with each subsequent year survived after 1, 2, 3, and 4 years post-diagnosis, respectively. Following variable screening through univariate Cox regression, BSR, and LASSO analysis, five factors-age, tumor stage, tumor size, radiotherapy, and chemotherapy-were ultimately identified for constructing the CS-nomogram model. The performance of the nomogram model was validated through discrimination and calibration assessments in both the training and validation cohorts. Furthermore, we confirmed that the effectiveness of the CS-nomogram in stratifying GSM patient risk status.ConclusionThis nationwide study delineated the CS of patients diagnosed with GSM. Utilizing national data, a CS-nomogram could provide valuable guidance for patient counseling during follow-up and risk stratification.
Dendrites contribute to the gradient of intrinsic timescales encompassing cortical and subcortical brain networks
Authors: Wu Kaichao , Gollo Leonardo L. 
Published: September 2024

IntroductionCytoarchitectonic studies have uncovered a correlation between higher levels of cortical hierarchy and reduced dendritic size. This hierarchical organization extends to the brain's timescales, revealing longer intrinsic timescales at higher hierarchical levels. However, estimating the contribution of single-neuron dendritic morphology to the hierarchy of timescales, which is typically characterized at a macroscopic level, remains challenging.MethodHere we mapped the intrinsic timescales of six functional networks using functional magnetic resonance imaging (fMRI) data, and characterized the influence of neuronal dendritic size on intrinsic timescales of brain regions, utilizing a multicompartmental neuronal modeling approach based on digitally reconstructed neurons.ResultsThe fMRI results revealed a hierarchy of intrinsic timescales encompassing both cortical and subcortical brain regions. The neuronal modeling indicated that neurons with larger dendritic structures exhibit shorter intrinsic timescales. Together these findings highlight the contribution of dendrites at the neuronal level to the hierarchy of intrinsic timescales at the whole-brain level.DiscussionThis study sheds light on the intricate relationship between neuronal structure, cytoarchitectonic maps, and the hierarchy of timescales in the brain.
Impact of the Promoting Physical Activity in Regional and Remote Cancer Survivors intervention on health-related quality of life in breast and colorectal cancer survivors
Authors: Hardcastle Sarah J. , Leyton-Román Marta , Maxwell-Smith Chloe , Hince Dana 
Published: September 2024

BackgroundThe PPARCS trial examined the efficacy of a distance-based wearable and health coaching intervention to increase physical activity (PA) in breast and colorectal cancer (CRC) survivors living in non-metropolitan areas. This paper examines the effects of the intervention on health-related quality of life (HRQoL) at 12 weeks (T2; end of intervention) and 24 weeks (T3; follow-up).MethodsParticipants that were insufficiently physically active and had successfully completed cancer treatment were randomised to an intervention or control group. PA was assessed using an ActiGraph (GT9X) at baseline, T2, and T3. Intervention effects on HRQoL were analysed using quantile regression comparing treatment groups across time.ResultsA total of 87 were randomised to intervention and control groups. There were generally no statistically significant differences between the groups on any HRQoL item except for pain. There was an arm (F(1, 219) = 5.0. p = 0.027) and time (F(2,221) = 4.8, p = 0.009) effect, reflecting the higher pain scores in the control group when collapsed across time points (median difference 16.7, CI 1.9 to 31.4, p = 0.027). For global HRQoL, the intervention group increased by 8.3 points between T1 and T2. The overall group median when collapsed across time was 16.7 points CI 8.2 to 25.2, p &lt;0.001) greater in the intervention group than controls.ConclusionsWhile the PPARCS intervention resulted in significant increases in PA, participants indicated a high HRQoL at baseline, leaving little room for improvement. Findings suggest that PA may improve global HRQoL and pain in breast and CRC survivors.
Case report: Staged tension-reducing excision of giant acquired vulvar lymphangioma secondary to cervical cancer surgery
Authors: Hu Ling-Juan , Fang Hao-Ming , Lin Huan-Mei , Kang Xu , Lin Ying , Xiao Jing 
Published: September 2024

IntroductionAcquired vulvar lymphangioma (AVL), a rare disease caused by the dilation of superficial lymphatic vessels secondary to deep lymphatic vessel injury, is characterized by a wide range of morphological diversity and massive exudate. This morphological heterogeneity has often led to misdiagnosis or non-diagnosis. The management of AVL presents a therapeutic challenge due to the absence of a standardized treatment protocol.Case presentationA 53-year-old female patient, previously received surgical treatments for stage IIb cervical squamous cell carcinoma, presented with vulvar enlargement and copious amount of yellow exudate seven years post-treatment. Clinically, the patient exhibited chronic vulvar swelling, with easily-exudated nodules. The vulvar biopsy revealed lymphatic vessel dilation with lymphocyte infiltration, consistent with AVL. Due to the extensive lesions and severe exudate, staged excisions of bilateral vulvar lesions were performed at one-month intervals. Follow-up examinations of this patient for one-year post-surgery showed no evidence of recurrence.ConclusionIn this instance, AVL manifest secondary to cervical cancer surgery, as a result of damage to the deep lymphatic vessels of the vulva, with characteristic symptoms of copious amounts of exudate and vulvar lesions with diverse morphologies, which provides a cautionary note for physicians. Besides, the staged resection strategy in this case may offer insights into surgical treatment protocol for extensive AVL.
Identification of a novel FERMT1 variant causing kindler syndrome and a review of the clinical and molecular genetic features in Chinese patients
Authors: Zhang Qiang , Yang Qi , Shen Fei , Wang Linlin , Luo Jingsi 
Published: September 2024

BackgroundKindler Syndrome (KS, OMIM #173650), a rare autosomal recessive genetic disorder, is characterized by a spectrum of symptoms such as cutaneous fragility, blistering, photosensitivity, and mucosal involvement. These symptoms result from variations in the FERMT1 gene (Fermitin family member 1, OMIM: 607900), encoding kindlin-1, an essential component of focal adhesions.ObjectiveThis study aims to ascertain the potential pathogenicity of a FERMT1 variant identified in a Chinese patient and to explore the phenotypic and molecular genetic characteristics of all reported cases of Kindler Syndrome in the Chinese population.MethodsWhole-exome sequencing (WES) was performed on the patient to identify candidate variants associated with KS, and Sanger sequencing was utilized to authenticate their presence and origin. To further assess the potential impact of these genetic variants, we employed a variety of in silico prediction tools. Concurrently, a review of various databases was undertaken to ascertain and consolidate information regarding cases of KS in Chinese families.ResultsWe identified a novel likely pathogenic frameshift variant in the FERMT1 gene, specifically c.567_579delTATATATGACCCC (p.Ile190Serfs*10). The clinical presentation of this patient aligns with the diagnostic criteria for KS. The literature review reveals that the core clinical features of KS reported in the Chinese population include skin abnormalities (100%), as well as hyperkeratosis of the palms and soles (91.70%). Other clinical phenotypes encompass nail abnormalities (77.78%), abnormalities of the fingers/toes (75.00%), oral damage (70.00%), eye abnormalities (57.14%), and constipation (50.00%).ConclusionOur study enriches the genetic landscape of KS in the Chinese population and augments the understanding of phenotypic variability resulting from FERMT1 gene variants. The findings hold considerable significance for refining variant-based screening, genetic diagnosis, and comprehending the molecular pathogenesis underlying FERMT1-related disorders.
Exploring the potent enhancement effects of plyometric training on vertical jumping and sprinting ability in sports individuals
Authors: Xie Lin , Chen Jiayong , Dai Jing , Zhang Wenfeng , Chen Lunxin , Sun Jian , Gao Xiang , Song Junyi , Shen Hailun 
Published: September 2024

ObjectiveThis meta-analysis examines the impact of different combinations of plyometric training (complexity, training volume, and rest intervals) on immediate vertical jump and sprint performance in athletes.MethodsA systematic search was conducted in four databases, and Cochrane guidelines were used to evaluate the quality of included studies. Review Manager 5.4 software was employed to analyze outcome measures. Nineteen randomized controlled trials involving 293 participants were included.ResultsSingle plyometric training-induced post-activation potentiation (PAP) had a slight positive effect on vertical jump performance [SMD = −0.24, 95% CI (−0.38, −0.1), P = 0.0009]. Optimal results were observed with rest intervals of 0.3–4 min (SMD = 0.30, P = 0.0008). Sprint performance showed slight improvement [SMD = 0.27, 95% CI (0.03, 0.52), P = 0.03]. Complex plyometric training had a moderate effect on vertical jump performance [SMD = 0.58, 95% CI (−0.86, −0.23), P = 0.002], with the best outcomes seen with rest intervals exceeding 8 min (SMD = 0.77). Sprint performance also improved significantly [SMD = 0.8, 95% CI (0.01, 1.59), P = 0.05]. Single-session plyometric training did not significantly enhance vertical jump performance [SMD = −0.19, 95% CI (−0.41, −0.02), P = 0.07], but had a notable effect on sprint performance [SMD = 0.8, 95% CI (0.01, 1.59), P = 0.05], particularly with rest intervals exceeding 8 min (SMD = 0.77). Multiple-session plyometric training improved vertical jump (SMD = 0.43, 95% CI [0.01, 1.59), P = 0.00001 &lt; 0.05], with optimal effects observed at rest intervals of 5–7 min (SMD = 0.64). Sprint performance also improved [SMD = 0.46, 95% CI (0.01, 0.81), P = 0.01 &lt; 0.05].ConclusionPlyometric training as an activation method has significant enhancing effects, depending on training complexity, volume, and rest intervals.
Regulatory effects of tea polysaccharides on hepatic inflammation, gut microbiota dysbiosis, and serum metabolomic signatures in beef cattle under heat stress
Authors: Li Fan , Xu Jun , Xie Min , Fei Dan , Zhou Yaomin , Li Xiong , Guang Yelan , Gong Lihui , Hu Lizhen , Feng Fan 
Published: September 2024

BackgroundLong-term heat stress (HS) severely restricts the growth performance of beef cattle and causes various health problems. The gut microbiota plays a crucial role in HS-associated inflammation and immune stress involving lymphocyte function. This study investigated the effects of dietary tea polysaccharide (TPS), a natural acidic glycoprotein, on HS-induced anorexia, inflammation, and gut microbiota dysbiosis in Simmental beef cattle.MethodsThe cattle were divided into two groups, receiving either normal chow or normal chow plus TPS (8 g/kg, 0.8%). Transcriptome sequencing analysis was used to analysis the differential signaling pathway of liver tissue. 16S rDNA sequencing was performed to analysis gut microbiota of beef cattle. Serum metabolite components were detected by untargeted metabolomics analysis.ResultsHepatic transcriptomics analysis revealed that differentially expressed genes in TPS-fed cattle were primarily enriched in immune processes and lymphocyte activation. TPS administration significantly reduced the expression of the TLR4/NF-κB inflammatory signaling pathway, alleviating HS-induced hepatic inflammation. Gut microbiota analysis revealed that TPS improved intestinal homeostasis in HS-affected cattle by increasing bacterial diversity and increasing the relative abundances of Akkermansia and Alistipes while decreasing the Firmicutes-to-Bacteroidetes ratio and the abundance of Agathobacter. Liquid chromatography-tandem mass spectrometry (LC‒MS/MS) analysis indicated that TPS significantly increased the levels of long-chain fatty acids, including stearic acid, linolenic acid, arachidonic acid, and adrenic acid, in the serum of cattle.ConclusionThese findings suggest that long-term consumption of tea polysaccharides can ameliorate heat stress-induced hepatic inflammation and gut microbiota dysbiosis in beef cattle, suggesting a possible liver-gut axis mechanism to mitigate heat stress.