bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insulin-mediated pseudoacromegaly: a report of two pediatric patients
Authors: Inman Mark , Nour Munier A. 
Published: December 2017

Abstract

Background:
Insulin-mediated pseudoacromegaly is a rarely described pediatric phenotype. We present two patients displaying excessive growth associated with marked acanthosis nigricans, hyperinsulinemia and metabolic dysregulation.

Case presentation:
Both patients, of First Nations descent, presented with excessive growth – patient one at 3.92 years (height z-score +3.75) and patient two at 9.0 years (height z-score 5.15). Insulin-like growth factor-1 (IGF-1) levels were normal with appropriate growth hormone suppression, yet marked hyperinsulinemia. Prepubescent growth velocities exceeded 9 cm/year, resulting in final adult height predictions exceeding 3 standard deviations (SDs) of predicted. Clinical courses were complicated by type 2 diabetes, marked acanthosis nigricans and long-standing psychosocial distress.

Conclusions:
Pediatric patients with insulin-mediated pseudoacromegaly are at risk of significant physical, metabolic and psychosocial comorbidities. Unlike adults, the implications in childhood prompt consideration for therapies to decelerate linear growth and avert progression to metabolic dysregulation. Increased recognition of this condition may improve pathophysiological understanding, diagnostic criteria and therapeutic options.
Constitutionalism, Cheap Indeterminism and the Grounding Problem
Authors: Campdelacreu Marta 
Published: December 2017

Abstract
Thomas Sattig has argued recently that constitutionalism renders determinism about the actual world false, just in virtue of ordinary facts about ordinary middle-sized material objects. However, it seems that, if determinism about the actual world is false, this should be so for reasons of physics rather than in virtue of ordinary facts about ordinary objects. This is the problem of cheap indeterminism. Sattig also claims, however, that constitutionalists can solve this problem if they abandon an attractive and promising solution to the classical grounding problem affecting their view. In this paper I argue that, against his claims, constitutionalists can solve the problem of cheap indeterminism and the grounding problem simultaneously.
Crystal structure of [N,N-bis((pyrrol-2-yl)ethylidene)butane-1,4-diamine-κ4
N,N′,N′′,N′′′]-nickel(II), C16H20N4Ni
Authors: Mao Pan-Dong , Zhao Xiao-Lei , Yang Qing-Wen , Yang Miao , Wang Yuan 
Published: December 2017

Abstract
C16H20N4Ni, monoclinic, P21/n (no. 14), a = 7.6578(10) Å, b = 17.184(2) Å, c = 11.6581(15) Å, β = 100.837(2)°, V = 1506.7(3) Å3, Z = 4, R
gt(F) = 0.0356, wR
ref(F
2) = 0.0945, T = 296(2) K.
The post-morphological analysis of electrospun vascular grafts following mechanical testing
Authors: Yalcin Enis Ipek , Gok Sadikoglu Telem , Horakova Jana , Lukas David 
Published: December 2017

Abstract
Vascular grafts provide promising scaffolds for patients recuperating from cardiovascular diseases. Since it is necessary to mimic the native vessel in order to overcome the limitations of currently employed synthetic prostheses, researchers are tending to focus on the design of electrospun biodegradable multi-layer scaffolds which involves varying either the polymer type or constructional properties in each layer which, in turn, reveals the importance of layer interactions and their composite effect on the final multi-layer graft. This study describes the fabrication of biodegradable single-layer tubular scaffolds from polycaprolactone and poly(L-lactide)caprolactone polymers composed of either randomly distributed or, preferably, radially oriented fibers. Subsequently, bi-layer scaffolds were fabricated with a randomly distributed inner layer and a radially oriented outer layer from various polymer couple variations. The study focuses on vascular graft production technology including its morphology and mechanical properties. The post-morphologies of single-layer and bi-layer tubular scaffolds designed for vascular grafts were investigated as a continuation of a previously performed analysis of their mechanical properties. The results indicate that the mechanical properties of the final bi-layer grafts were principally influenced by the radially oriented outer layers acting as the tunica media of the native vessels when the appropriate polymer couples were chosen for the sub-layers.
Loss of Intercalated Cells (ITCs) in the Mouse Amygdala ofTshz1Mutants Correlates with Fear, Depression, and Social Interaction Phenotypes
Authors: Kuerbitz Jeffrey , Arnett Melinda , Ehrman Sarah , Williams Michael T. , Vorhees Charles V. , Fisher Simon E. , Garratt Alistair N. , Muglia Louis J. , Waclaw Ronald R. , Campbell Kenneth 
Published: December 2017

The intercalated cells (ITCs) of the amygdala have been shown to be critical regulatory components of amygdalar circuits, which control appropriate fear responses. Despite this, the molecular processes guiding ITC development remain poorly understood. Here we establish the zinc finger transcription factor Tshz1 as a marker of ITCs during their migration from the dorsal lateral ganglionic eminence through maturity. Using germline and conditional knock-out (cKO) mouse models, we show thatTshz1is required for the proper migration and differentiation of ITCs. In the absence ofTshz1, migrating ITC precursors fail to settle in their stereotypical locations encapsulating the lateral amygdala and BLA. Furthermore, they display reductions in the ITC marker Foxp2 and ectopic persistence of the dorsal lateral ganglionic eminence marker Sp8.Tshz1mutant ITCs show increased cell death at postnatal time points, leading to a dramatic reduction by 3 weeks of age. In line with this,Foxp2-null mutants also show a loss of ITCs at postnatal time points, suggesting thatFoxp2may function downstream ofTshz1in the maintenance of ITCs. Behavioral analysis of maleTshz1cKOs revealed defects in fear extinction as well as an increase in floating during the forced swim test, indicative of a depression-like phenotype. Moreover,Tshz1cKOs display significantly impaired social interaction (i.e., increased passivity) regardless of partner genetics. Together, these results suggest thatTshz1plays a critical role in the development of ITCs and that fear, depression-like and social behavioral deficits arise in their absence.SIGNIFICANCE STATEMENTWe show here that the zinc finger transcription factor Tshz1 is expressed during development of the intercalated cells (ITCs) within the mouse amygdala. These neurons have previously been shown to play a crucial role in fear extinction.Tshz1mouse mutants exhibit severely reduced numbers of ITCs as a result of abnormal migration, differentiation, and survival of these neurons. Furthermore, the loss of ITCs in mouseTshz1mutants correlates well with defects in fear extinction as well as the appearance of depression-like and abnormal social interaction behaviors reminiscent of depressive disorders observed in human patients with distal 18q deletions, including theTshz1locus.
Development of a method for monitoring personal exposure to benzyl violet 4B and direct blue 15 in workplace air
Authors: Takeuchi Akito , Ogawa Yoshihiro , Nishinoiri Osamu , Kanno Seiichiro , Shimizu Hidesuke 
Published: December 2017

Abstract

Objectives
The purpose of this research was to develop a method for monitoring personal exposure to benzyl violet 4B (BV) and direct blue 15 (DB) in workplace air for risk assessment.

Methods
We evaluated the utility of the proposed method by examining the following: recovery; method limit of quantification; reproducibility; and storage stability of the samples.

Results
An air sampling cassette containing a glass fiber filter was chosen as the sampler. BV and DB were extracted from the sampler filters with a solution of water and methanol (7 : 3, v/v) and then analyzed by a highperformance liquid chromatograph equipped with a photo-diode array detector. The overall recoveries from spiked samplers were 94-102% and 94-99% for BV and DB, respectively. The recovery after seven days of storage at 4°C exceeded 95%. The method limits of quantification were 0.250 and 1.25 μg/sample for BV and DB, respectively. The relative standard deviations, which represent the overall reproducibility defined as precision, were 0.6-4.1% and 0.8-2.9% for BV and DB, respectively.

Conclusions
The proposed method enables 4 h personal exposure monitoring of BV and DB at concentrations of 1-2,000 μg/m3 for BV and 5-2,000 μg/m3 for DB, with a 240 l sampling. Thus, the proposed method is useful for estimating worker exposure to BV and DB.
Challenge or hindrance: Does job stress affect presenteeism among Chinese healthcare workers?
Authors: Yang Tianan , Ma Mingxu , Zhu Mingjing , Liu Yuanling , Chen Qian , Zhang Shiyang , Deng Jianwei 
Published: December 2017

Abstract

Background
We examined the effects of challenge stress and hindrance stress on general health and presenteeism among Chinese healthcare workers.

Methods
Structural equation modeling was used to evaluate data from a national hospital survey in China (n= 1392). Job stress, general health, and presenteeism were measured by the Perceived Ability to Work Scale, the 8-item Short-Form Health Survey, and the Challenge- and Hindrance-Related Self-reported Stress Scale.

Results
Challenge stress and hindrance stress were significantly positively correlated (β = 0.62, SE = 0.021; p &lt; 0.001). Challenge stress was directly negatively associated with presenteeism (β = -0.05, SE 0.037; p &lt; 0.001), while hindrance stress was positively associated with presenteeism (β = 0.25, SE = 0.040; p &lt; 0.001). These associations with presenteeism were partially mediated by health.

Conclusions
Hospital managers should provide healthcare workers with an appropriate level of challenge, but employee health is the most important consideration. Further efforts targeting job stress and health of junior healthcare workers are required.
Risco cardiovascular avaliado pelo índice de conicidade em mulheres no climatério: análise comparativa entre os períodos pré e pós-menopausa
Authors: Dallazen Fernanda , Winkelmann Eliane Roseli , Berlezi Evelise Moraes 
Published: December 2017

OBJETIVOS: Avaliar o risco cardiovascular pelo índice de conicidade em mulheres no período do climatério, comparando o período pré e pós-menopausa.MÉTODOS: Este estudo transversal com dados secundários, realizado a partir do banco de dados da pesquisa de coorte "Envelhecimento Feminino" avaliou mulheres entre 35 e 65 anos de idade, cadastradas nas Unidades da Estratégia Saúde da Família do município de Ijuí, Rio Grande do Sul, Brasil. Foram incluídas mulheres que tinham avaliação das condições gerais de saúde, do estado nutricional, clínica e bioquímica; e excluídas as com diagnóstico de doença cardiovascular e diabetes mellitus tipo I. O risco cardiovascular foi determinado obtendo-se o índice de conicidade, a partir das medidas de peso corporal, estatura e circunferência da cintura. As participantes foram divididas em dois grupos: pré-menopausa e pós-menopausa.RESULTADOS: A amostra foi composta por 102 mulheres, cuja média de idade era 51,5±7,9 anos. Destas, 41 (40,2%) estava na pré-menopausa e 61 (59,8%) na pós-menopausa. Todas as participantes possuíam alto risco cardiovascular pelo índice de conicidade, mas naquelas no período pós-menopausa, a média desse índice foi maior em comparação às que estavam na pré-menopausa (1,25±0,0 vs.1,19±0,9). Considerando apenas as mulheres com risco cardiovascular baixo, as do grupo pós-menopausa, em comparação ao pré-menopausa, apresentavam maiores valores de circunferência da cintura (84,8±5,5 vs. 78,0±7,5; p=0,005) e percentual gordura corporal (36,8±5,5 vs. 32,9±6,5; p=0,005). Considerando as participantes com risco cardiovascular elevado, o grupo na pós-menopausa apresentou valores maiores para o percentual de gordura corporal (39,8±4,0 vs. 35,7±6,9; p=0,010), colesterol total (204,9±42,7 vs.184,2±40,0; p=0,005) glicose (107,3±65,4 vs. 82,5±14,1; p=0,001) e colesterol ligado à lipoproteína de baixa densidade (132,4±41,8 vs. 109,3±38,8; p=0,002).CONCLUSÕES: A utilização do índice de conicidade pelas equipes da atenção primária indicou que nesta amostra de mulheres, independente da fase do climatério, havia condições subclínicas para o desenvolvimento de doença cardiovascular, mais acentuadas no período pós-menopausa.
Model for compressive strength development of OPC concrete and fly ash concrete with time
Authors: Vijaya Bhaskara Gollapalli S. , Balaji Rao Kanchi , Anoop Madambikkattil B. 
Published: December 2017

Towards promoting the use of higher percentage levels of fly ash in concrete in order to reduce its carbon dioxide footprint, rational models for estimating the mechanical properties of fly ash concrete (FAC) are required. A simple model for predicting the mean compressive strength development with age of both FAC and ordinary Portland cement concrete (OPCC) is proposed. The model is applicable to concrete containing 0–75% class F fly ash, type I cement and normal-weight aggregates and having a 28 d average compressive strength up to 65 MPa. The model was developed based on two-stage regression analyses of the experimental data of 512 concrete mixtures collected from the literature. The predictions made using the model were found to be in good agreement with the results of experimental investigations carried out at CSIR-Structural Engineering Research Centre and additional experimental data collected from the literature. From a comparison with a reaction-kinetics-based strength development model available in the literature, it was noted that the proposed model is able to reflect the reaction kinetic processes involved in strength development in both OPCC and FAC. The proposed model should help in developing specifications related to strength development for FAC similar to that given in fib Model Code 2010 for OPCC.
Comparación in vitro de la frecuencia de micronúcleos provocada por dos formas de administración del tratamiento preventivo de la anemia ferropénica
Authors: Gambaro Rocío Celeste , Seoane Analía , Padula Gisel 
Published: December 2017

La deficiencia de hierro es la carencia nutricional más prevalente y la principal causa de anemia a escala mundial. Los grupos poblacionales con mayor riesgo son los niños entre 6 y 24 meses de edad y las mujeres embarazadas. En los niños, la causa más común es el aumento del requerimiento ferroso, relacionado con la mayor velocidad de crecimiento. La Sociedad Argentina de Pediatría recomienda, como tratamiento preventivo de la anemia, la suplementación diaria con sulfato ferroso. Sin embargo, a partir de la década del 90, se ha planteado como tratamiento alternativo la suplementación con una dosis semanal única, la cual provocaría menos efectos adversos. En el presente trabajo se propone analizar el daño genómico inducido por ambos tipos de administración del hierro en linfocitos humanos cultivados in vitro. Los linfocitos fueron cultivados durante 7 días en 4 frascos: 1- Control negativo; 2- Tratamiento diario (0,13mg SO4Fe/día); 3- Tratamiento semanal (0,55mg SO4Fe/semanal); 4- Control positivo (Bleomicina). El daño cromosómico provocado por el exceso de hierro, se determinó a través del ensayo de micronúcleos por bloqueo de la citocinesis y se estableció el índice mitótico, indicador de crecimiento celular. Las diferencias fueron evaluadas estadísticamente por ANOVA Simple. La frecuencia de micronúcleos resultó significativamente aumentada para el tratamiento diario respecto del semanal y del control negativo. Los resultados se corresponden con los esperados, mostrando en los cultivos con tratamiento semanal, una disminución de la producción de radicales libres del oxígeno y, por lo tanto, un menor daño sobre el ADN.
Desafios e oportunidades da Educação para a Cidadania
Authors: Serrão Jacinto , Freitas Maria João 
Published: December 2017

A cidadania é uma meta do sistema educativo, cujo processo exige mais do que a sua prescrição normativa ou declarativa. Partindo da constatação empírica do fosso entre o currículo prescrito e a formação e prática dos docentes na área da cidadania importa compreender os fatores explicativos desse problema, além de fomentar o conhecimento para promover propostas políticas e medidas nos domínios curriculares e programáticos na área da cidadania, com vista à sua realização prática. A metodologia é quantitativa e insere-se num design de investigação inferencial. Este artigo realça resultados provados a partir do conhecimento dos principais atores educativos.
Los/as estudiantes de educación social y trabajo social ante la atención a personas mayores: Intereses profesionales
Authors: Dapia Conde Maria D. , Failde Garrido Jose Maria , Fernandez Gonzalez Maria Reyes 
Published: December 2017

La gerontología constituye uno de los ámbitos de intervención en auge para los titulados/as en Educación Social y Trabajo Social. Esta investigación tiene como objetivo identificar las preferencias vocacionales de estos estudiantes en relación a la intervención con personas mayores, a partir de un estudio cuasi-experimental, descriptivo y transversal, en base a la administración de un cuestionario. Globalmente, los resultados indican un escaso interés de los estudiantes por el colectivo de las personas mayores y un incremento de las preferencias por este grupo de edad en el último curso.
Indicadores tempranos de desarrollo pragmático y alteraciones del vínculo de apego
Authors: Botana Iria , Peralbo Manuel , García-Fernández Manuel 
Published: December 2017

El objeto de este trabajo es analizar el impacto de los hitos pragmáticos del desarrollo infantil en la detección precoz de los trastornos de la relación entre niños y cuidadores. La relevancia del trabajo reside en el valor predictivo de los marcadores de desarrollo pragmático temprano y su papel dentro de la díada madre-hijo. El estudio emplea los datos extraídos durante el proceso de baremación de la escala EDPRA. Los resultados sugieren que los Items de base interactiva que requieren de un adulto disponible se pueden asumir como indicadores tempranos de un apego seguro. La conclusión obtenida apunta al perfil de desarrollo pragmático del niño como signo de alerta del tipo de vínculo establecido con su cuidador principal
Impacto da implementação da estratégia Semantic Feature Analysis em turmas inclusivas
Authors: Verde Elisabete , Oliveira Sílvia , Cruz-Santos Anabela 
Published: December 2017

Este estudo quasi-experimental teve por finalidade analisar o impacto da estratégia de ensino-aprendizagem Semantic Feature Analysis (versão Português Europeu) na promoção do vocabulário, junto de 120 alunos, com e sem NEE, do 1.º e 2.º ciclos do Ensino Básico, distribuídos por três grupos de ensino. Concluiu-se que a SFA é uma estratégia motivadora, flexível e de fácil aprendizagem, tendo sido mais eficaz que os outros métodos de ensino implementados, contribuído para a promoção da aprendizagem do vocabulário, aquisição de conceitos teóricos e compreensão de textos. A dimensão do efeito foi .87 no 1.º ciclo, e .88 no 2.º ciclo.
Avaliação de projetos pedagógicos: estudo nos cursos de Bacharelado
Authors: Bittencourt Regina Lucia , Alves Maria Palmira Carlos 
Published: December 2017

Estudo de caso, com abordagem quanti-qualitativa. Os dados foram recolhidos através dos Projetos Pedagógicos dos Cursos (PPCs) dos Bacharelados Interdisciplinares em Saúde (BIS) da Universidade Federal do Recôncavo da Bahia, documentos normativos, inquéritos por entrevistas e questionários. Os resultados da investigação sugerem que os PPCs dos cursos apresentam propostas curriculares integradas, com enfoque na interdisciplinaridade, atividades e avaliação formativa; os docentes responsáveis pela reformulação e desenvolvimento do currículo não consideram o perfil do estudante; enfatiza-se a oralidade em detrimento da escrita académica, nas práticas pedagógicas.
Calidad de vida en adolescentes: Evaluación de necesidades basada en factores personales
Authors: Muñoz-Cantero Jesús Miguel , Losada-Puente Luisa 
Published: December 2017

Este trabajo explora la influencia de diversos factores personales (sexo, edad y presencia de NEAE) sobre la calidad de vida de la adolescencia. Mediante metodología cuantitativa, se aplica Cuestionario de Evaluación de la Calidad de Vida de Alumnos adolescentes (CCVA, Gómez-Vela y Verdugo, 2009) a 2220 estudiantes (12-19 años). Los resultados muestran mayor satisfacción con la vida en alumnado varón y más joven experimenta, y peor en alumnado con NEAE. Las tres variables estudiadas, de forma independiente, contribuyen a explicar las diferencias, pero no conjuntamente. Se propone continuar el estudio analizando la influencia de variables ambientales (familia, escuela).
Perspectiva de la orientación sobre los recursos en atención a la diversidad
Authors: Vázquez Varela Elia , Domínguez Rodríguez Víctor 
Published: December 2017

El objetivo de este estudio fue describir y constatar mediante la opinión de los responsables de los Departamentos de Orientación, la incidencia de los recursos en atención a la diversidad en los centros de educación secundaria obligatoria gallegos. En el estudio participaron 75 profesionales con edades entre los 25 y 65 años (M= 44.5; DT= 10.45). Se administró el cuestionario EVADIE y los resultados obtenidos muestran que los centros educativos cuentan con los recursos necesarios para la atención del alumnado diverso, fundamentalmente en personal especializado, formación que responde a las necesidades del profesorado y vinculación con centros externos de apoyo.
Importância do Acesso Aberto a Dados de Pesquisas na Formação de Cientistas
Authors: Marques da Silva Andréa Carla , Moura Rossana Coely de Oliveira 
Published: December 2017

Apresenta estudo sobre o mapeamento inédito de pesquisadores e especialistas que trabalham com o tema do Acesso Aberto a Dados de Pesquisa (AADP) no Brasil, a importância no fomento a pesquisas científicas. O estudo revelou que políticas voltadas ao AADP promovem, dentre outros benefícios, o estímulo à pesquisa colaborativa; a eficiência do gasto público; aumentos na qualidade dos resultados de pesquisa; maior participação dos cidadãos no processo científico e aceleração do processo de inovação a partir do acesso empresarial aos dados de pesquisa, fatores relevantes na capacitação dos cientistas atuais e formação de futuros pesquisadores.
Study on the use of mobile devices in schools: the case of Romania
Authors: Moraru Petronia , Marchitan Gabriela , Moraru Petrică , Hîrnea Carmen , Ungureanu Maria 
Published: December 2017

The current dynamics of society is relevant also for the educational systems. The integration of mobile devices in education, as a bridge between inside and outside educational activities, is not fully exploited. This paper will present a brief study regarding the mobile devices and ICT in Romanian educational system, and an analysis about teachers' skills and disponibility, to move to the next step of mobile-integrated educational system, the gap between the potential of the method BYOD/the schools' mobile devices, the practice of teaching using them, and the needs of students for their skills development, regarding of long life learning.