bluuebunny/crossref_metadata_2025_split huggingface dataset:
Determination of optimal dosage of extract of <i>Angelica gigas</i> Nakai against benign prostatic hyperplasia
Authors: Kang Jae Seon , Lee Jin Young 
Published: September 2024

Purpose: To investigate the effect of Angelica gigas Nakai ethanol extract (AGNEX) on benign prostatic hyperplasia (BPH) models induced by castration and testosterone propionate (TP) injection.
Methods: 30 rats were randomly divided into six groups of five rats each. One group was used as a normal control (CON) and the other groups were castrated and injected intraperitoneally with TP to induce BPH. Positive control group (PCON) was administered finasteride (5 mg/kg) for 4 weeks and BPH-induced group without treatment was used as negative control (NCON). Groups administered AGNEX (1.25 mg/kg (AG1.25), 5 mg/kg (AG5), or 10 mg/kg (AG10)) instead of finasteride were assigned as study groups. The complete blood cell and lipid profiles, liver and kidney function assays, serum 5α-reductase activity and DHT levels as well as the histological examination of prostate tissues were determined.
Results: The prostate volume of AG10 group decreased by approximately 35 % compared to BPH induced group (NCON). The prostate weight ratio decreased by 10 % in BPH + finasteride group compared to NCON group, and by 24 and 22 % in the AG5 and AG10 groups, respectively. AG10 group exhibited the lowest levels of 5α-reductase and dihydrotestosterone. Histopathological observations of prostate tissue showed normal cell shapes and reduced intraluminal polyp formation in the control and AGNEX-administered groups.
Conclusion: The administration of 10 mg/kg of AGNEX is optimal dose for protective effect against BPH. Therefore, AGNEX has potentials for further investigations as source of lead agents for BPH management.
<i>In vivo</i> acute toxicity, analgesic and anti-inflammatory activities of phenolic extract of <i>Matricaria pubescens</i>
Authors: Metrouh-Amir Hassiba , Amir Nadir 
Published: September 2024

Purpose: To evaluate the in vivo acute toxicity, analgesic and anti-inflammatory proprieties of the phenolic extract of Matricaria pubescens (Desf.) Schultz (Asteraceae).
Methods: Acute toxicity assessment was carried out on 18 mice that were divided equally into three groups and treated orally with saline, 2500 and 5000 mg/kg of M. pubescens extract, respectively. The evaluation of peripheral analgesic activity was done by applying acetic acid-induced contortion test on 40 mice. The mice were divided into 5 equal groups of 8 mice each. Negative and positive control groups were treated orally with saline (1 %) and acetylsalicylic acid (200 mg/kg), respectively. Other groups were treated with 50, 100 and 200 mg/kg of M. pubescens extract. Study groups were administered saline, diclofenac potassium (10 mg/kg) and M. pubescens extract orally at 50, 100, and 200 mg/kg. Central analgesic activity was carried out using the tail immersion test. The distribution and treatment of the mice was similar to the analgesic model. Anti-inflammatory effect was evaluated by carrageenan-induced mice paw edema.
Results: Acute toxicity results showed that the LD50 of M. pubescens phenolic extract is above 5000 mg/kg, which means that this extract is safe. Peripheral and central analgesic data revealed that different doses of extract significantly inhibited abdominal contractions and reduced pain caused by heat compared to control (p ˂ 0.05). Anti-inflammatory activity data indicate significant inhibition of inflammatory edema at various doses compared to diclofenac potassium (p ˂ 0.05).
Conclusion: The phenolic extract of M. pubescens exerts significant peripheral, central analgesic and anti-inflammatory activities in mice. However, further investigations are required to ascertain the potentials of the extract for its clinical development.
Oświeceniowa koncepcja nauki Andrzeja Trzcińskiego w Uwagach na Rozprawę o krytyce Stanisława Kostki Potockiego
Authors: Cygan Milena 
Published: September 2024

Artykuł dotyczy koncepcji nauki Andrzeja Trzcińskiego (1749–1823), krakowskiego profesora fizyki epoki oświecenia. W 1811 roku opublikował on Uwagi na Rozprawę o krytyce Stanisława Potockiego. Zazwyczaj tekst ten był postrzegany przez badaczy jako niewiele znaczące, złośliwe uwagi pod adresem Stanisława Potockiego (1755–1821) i jego dysertacji.
Celem artykułu jest wydobycie i ukazanie, że za argumentacją zawartą w Uwagach... stała odmienna względem Potockiego wizja nauki, a także kultury i sztuki.
W pierwszej kolejności zostało przedstawione kim był krakowski uczony oraz dlaczego jego postać i działalność pozostaje ciągle mało znana. Następnie na podstawie analiz tekstu Uwag... i porównań z Rozprawą o krytyce pokazano, że Trzciński był zwolennikiem empiryzmu, przeciwnikiem klasycyzmu (którego propagatorem był Potocki) oraz uczonym, który inspirował się sentymentalizmem i poglądami J.J. Rousseau. Wierny oświeceniowym ideałom Trzciński postulował badania nad Naturą. Uważał, że pierwszeństwo przed innymi dyscyplinami naukowymi mają nauki przyrodnicze, gdyż są użyteczne (ułatwiają życie, polepszają jego jakość oraz służą wszystkim, to znaczy dobru ogólnemu). Nauki piękne, sztuka zarezerwowane są dla nielicznych i nie przynoszą większych pożytków społeczności, poza przyjemnością i rozrywką.
W artykule poruszono również kwestię polskiego języka naukowego.
Aptekarstwo w polskich kalendarzach farmaceutycznych przełomu XIX i XX wieku. Prolegomena do badań
Authors: Żuk Anna 
Published: September 2024

Kalendarze na przełomie XIX i XX wieku były nieraz jedynym źródłem informacji o otaczającym ówczesnych ludzi świecie. Kalendarze farmaceutyczne w języku polskim wydawane były od roku 1878.
Obecnie piśmiennictwo dotyczące wydawnictw, jakimi były kalendarze, jest skromne. Kalendarze były publikacjami bardzo popularnymi, o szerokiej rozpiętości tematycznej i wysokim poziomie edytorskim, jednak nie doczekały się dotąd precyzyjnej definicji bibliologicznej.
Współcześnie niewiele miejsca poświęca się w pracach naukowych kalendarzom wydawanym w języku polskim dla farmaceutów, początkowo we Lwowie, a następnie w Warszawie, od roku 1878 do wybuchu I wojny światowej (ostatni kalendarz farmaceutyczny z tego okresu wydany był w roku 1914).
Celem pracy jest ukazanie aptekarstwa pod koniec XIX i na początku XX wieku na podstawie informacji zawartych w kalendarzach znajdujących się w zbiorach Muzeum Farmacji UJ CM w Krakowie, ponieważ kalendarze te stanowią cenne i bogate źródło wiedzy o tych czasach. Omawiane w niniejszej pracy kalendarze ukazywały się w latach 1878–1914 we Lwowie i w Warszawie. Zamieszczano w nich artykuły naukowe, manuały, wykazy aptek i aptekarzy prowadzących polskie apteki, reklamy, tablice i wykazy.
Analizowane kalendarze farmaceutyczne stanowiły ważne źródło wiedzy fachowej dla ówczesnych aptekarzy, ponieważ dostęp do podręczników farmaceutycznych był ograniczony. Kalendarze farmaceutyczne umożliwiały aptekarzom wykonywanie pracy zgodnie z przepisami prawa, reklamy ułatwiały zaopatrzenie aptek w niezbędne produkty, a spisy aptekarzy polskich i aptek działających pod różnymi zaborami nie tylko umożliwiały kontakt między aptekarzami, lecz także wzmacniały patriotyzm w aptekarzach oraz mobilizowały do wspólnej wytrwałej pracy na rzecz farmacji i odrodzenia Polski.
Academician V. H. Serheiev – Control System Designer, Founder of the Scientific and Design School, Honored Citizen of Kharkiv (on His 110th Birthday)
Authors: Tverytnykova Elena , Voitiuk Olena 
Published: September 2024

March 5, 2024 marks the 110th birthday of Volodymyr Hryhorovych Serheiev, an outstanding scientist, chief designer of control systems for strategic combat missiles, launch vehicles, spacecraft and transport modules of orbital complexes, Academician of the National Academy of Sciences of Ukraine and an Honored Citizen of Kharkiv. Despite his significant scientific achievements in the field of rocket and space engineering, the silhouette of V. H. Serheiev is hardly reflected in the modern history of science.
Based on representative sources, the article highlights the main achievements of the scientist in the field of dynamics of automatic control systems and the design of rocket and space engineering control systems. The summary of the most prominent space projects is based on the memories of witnesses and direct participants.
The personal qualities of V. H. Serheiev as the head of the Special Design Office No. 692 are noted. The historical retrospective describes technical developments and inventions meant to improve the control systems of intercontinental ballistic missiles R-16, R-16У, R-36, R-36П, R-36 orbital, R-36М, R-36М UTTH, UR-100N, UR-100HU, and R-36М2. At the initiative of V. H. Serheiev, complex stands were developed, which worked non-stop in all modes of operation of the necessary equipment and solved complex scientific and technical problems of creating an on-board digital computer. V. H. Serheiev was the chief control system designer of space launch vehicles Kosmos, Kosmos-2, Cyclone-2, and Cyclone-3 and Tselina series spacecraft. The article features innovative solutions implemented under Serheiev’s leadership during the creation of the Energia launch vehicle, supply vehicles of the Almaz space rocket system and target orbital modules of the Saliut and Myr space stations, and international launch vehicles Dnipro, Rokit and Strila.
The article considers the issues of V. H. Serheiev’s direct participation in the organization of the training system for scientific personnel in the relevant specialties at Ukraine’s higher education institutions, as well as the development of international cooperation. It is substantiated that the scientist created one of the leading science and construction schools for the development of control systems for rocket and space technology, which is internationally recognized.
The authors emphasize that V. H. Serheiev devoted a lot of attention to people. At his initiative and with his support, a district named after the founder of aerodynamics, M. Y. Zhukovskyi, was created in Kharkiv for the employees of “Hartron” enterprise. The district was not far from the enterprise and had a well-developed infrastructure, such as kindergartens, schools, shops, a swimming pool and a complex of residential buildings.
Investigating factors influencing PM2.5 threshold exceedance in Nigeria using multivariate logistic regression analysis
Authors: Igbawua Tertsea , Tyovenda Aondongu Alexander , Sombo Terver , Echi Idugba Mathias , Ujoh Fanan 
Published: September 2024

The understanding of the drivers of fine particulate matter of diameter less than or equal to 2.5 micrometers (PM2.5) in Nigeria will greatly assist policymakers and other stakeholders in developing appropriate air quality management strategies to protect the health of the public. This research analyzed the drivers of PM2.5 threshold exceedance (PTE) in Nigeria from 2000 to 2022, employing a multivariate logistic regression (MLR) model. The work assessed aerosol emission variables (AEVs) and meteorology variables (MEVs) to understand their impact on PM2.5 concentrations. Results showed a significant spatial heterogeneity in the trend of PM2.5 concentrations, with increasing values in all the study areas. The estimated coefficients of black carbon emission (BCEM) and sulfate emission (SUEM) showed a significant positive response, exacerbating the threshold exceedance in Abuja and Lagos, while dust emission (DUEM) had a significant positive response in Kano and Lagos. On the other hand, OCEM had a negative association in all the study locations. The MEV variables of sea level pressure (SLP), relative humidity (RH), planetary boundary layer height (PBLH), and wind speed (WS) had significant negative responses in Abuja, while RH and WS were significant in Kano, and RH, PBLH, and precipitation (P) were significant in Lagos, indicating that the PM2.5 concentrations decrease with increasing values of these factors; however, temperature (TMP) had a significant positive response in Lagos but was not significant in Abuja and Kano. The output of the study revealed complex relationships between aerosol emissions, climate, and other environmental variables driving the PTE in Nigeria.
Memoria 2024
Authors: Red Internacional de Investigación Galileo Ecuador  , Ediciones ACVENISPROH 
Published: September 2024

Indudablemente, el Congreso Internacional Multidisciplinario HUMANIDAD Ecuador, que llega a su cuarta edición en el año 2024, se consolida como un foro académico de primera línea, dedicado a fomentar un ambiente idóneo para la disertación, el intercambio y difusión del conocimiento científico.
Este evento, fiel a los principios de la ciencia abierta, busca integrar diversas perspectivas y áreas del saber, conforme a los estándares de la UNESCO.
El objetivo permanente de esta iniciativa subyace en el fortalecimiento de un entorno académico de excelencia que promueva una discusión rigurosa sobre temas científicamente relevantes. Esta convergencia de saberes ha logrado convocar a una comunidad internacional de docentes, estudiantes, profesionales, innovadores e investigadores procedentes de América Latina, el Caribe y África, quienes aportan a la construcción de una agenda académica global y diversificada.
El Comité Organizador se enorgullece de facilitar este encuentro en una modalidad virtual y completamente asincrónica, característica que ha permitido una participación flexible y un diálogo dinámico entre los participantes. La tecnología empleada ha sido fundamental para superar las barreras físicas y temporales, creando un ambiente didáctico que favorece la interacción en un contexto de creciente complejidad global.
La presente edición de la memoria del congreso sirve como testimonio del esfuerzo y dedicación de los participantes, que han superado desafíos significativos en el contexto de la investigación en América Latina y África, demostrando la resiliencia y el espíritu científico de nuestra comunidad.
Este encuentro evidencia la capacidad de adaptación y renovación constante de la academia, enfrentándose a desafíos y superándolos en su noble misión de contribuir al avance del conocimiento. Extendemos nuestra gratitud a todas las instituciones académicas colaboradoras y a nuestros patrocinadores, cuyo apoyo ha sido fundamental para la realización de este evento.
Así mismo, quiero destacar un reconocimiento especial a todos los participantes en calidad de asistentes, conferencistas y ponentes de América, África y Europa de países como Angola, Argentina, Brasil, Bolivia, Chile, Colombia, Cuba, Ecuador, España, México, Perú, República Dominicana y Venezuela.
Su enriquecedora participación ha sido no sólo un honor, sino también una piedra angular para el éxito de nuestro congreso. ¡Felicitaciones a todos!, y que el espíritu de la humanidad nos fortalezca siempre.
¡Enhorabuena! ¡Que viva la humanidad!
Dr. Franklin Salas Aular Coordinador Editorial
Pengaruh Perputaran Piutang dan Perputaran Modal Kerja Terhadap Likuiditas Pada PT.Kresna Reksa Finance
Authors: Dewi Asma Sari , Hidayat R Taufik , Hotang Keri Boru 
Published: September 2024

Penelitian ini adalah penelitian kuantitatif yang dilakukan pada PT.Kresna Reksa Finance Cabang Bekasi. Penelitian ini bertujuan untuk mengetahui perputaran piutang dan perputaran modal kerja berpengaruh terhadap likuiditas perusahaan, Metode penelitian yang digunakan adalah metode purposive sampling dengan menggunakan SPSS. Total sampel yang di gunakan 36 sampel yang diambil dari laporan keuangan PT.Kresna Reksa Finance. Hasil berdasarkan SPSS menunjukkan bahwa perputaran piutang dan perputaran modal kerja memiliki pengaruh terhadap likuiditas perusahaan, perputaran piutang memiliki pengaruh terhadap likuiditas perusahaan dan perputaran modal kerja memiliki pengaruh terhadap likuiditas perusahaan.
Analisis Peran Account Officer dalam Menekan Pinjaman Bermasalah di PT BPR NBP 9 Pangururan
Authors: Kenedy Olivia Agatha , Sitorus Jessy Safitri 
Published: September 2024

Pinjaman bermasalah merupakan salah satu resiko yang akan dihadapi lembaga keuangan termasuk di PT BPR nbp 9 Pangururan. Resiko ini timbul karena ketidakmampuan nasabah peminjam dalam membayar sebagian atau seluruh perjanjian pinjaman yang telah disepakati bersama, banyak cara yang dapat dilakukan dalam mengatasi pinjaman bermasalah, dalam hal ini peran Account Officer sangat dibutuhkan, karena dari awal proses pengajuan pinjaman sampai dengan strategi menyelesaikan jika terjadi pinjaman bermasalah diselesaikan oleh Account officer. Selain itu manajemen pinjaman yang baik serta Account officer yang terjun kelapangan dalam memonitor usaha yang dijalankan nasabah juga dapat mengurangi paling tidak resiko terjadinya pinjaman bermasalah. Peran Account Officer dibutuhkan dalam menyelesaikan pinjaman bermasalah dalam lembaga keuangan. Tujuan penelitian ini adalah untuk menganalisis peran accont officer dalam menekan pinjaman bermasalah pada PT BPR nbp 9 Pangururan. Jenis penelitian ini adalah kualitatif yaitu suatu penelitian yang bersifat menjelaskan analisis peran account officer dalam menekan pinjaman bermasalah pada PT BPR nbp 9 Pangururan.
Kata Kunci :Account Officer, Manajemen Pinjaman, Pinjaman Bermasalah, Stategi Mengatasi Pinjaman Bermasalah.
PENGARUH SIKAP MANDIRI, MOTIVASI, PENGETAHUAN KEWIRAUSAHAAN TERHADAP MINAT BERWIRAUSAHA (Studi kasus pada UMKM muda yang baru memulai usaha Di Kelurahan Kota Matsum II, Medan di bidang kuliner)
Authors: Dwiyanthi Sheilla , Hafizah  , Aulia Arief Nasution  
Published: September 2024

Penelitian ini bertujuan untuk mengetahui apakah sikap mandiri, motivasi, pengetahuan kewirausahaan berpengaruh terhadap minat berwirausaha, untuk mengetahui apakah sikap mandiri berpengaruh terhadap minat berwirausaha, untuk mengetahui apakah motivasi berpengaruh terhadap minat berwirausaha, untuk mengetahui apakah pengetahuan kewirausahaan berpengaruh terhadap minat berwirausaha. Dalam penelitian ini, populasi terdiri dari 1683 warga yang tinggal Di Kelurahan Kota Matsum II Medan. Sampel yang diambil sebanyak 115 orang yang merupakan pelaku UMKM muda yang berada Di Kelurahan Kota Matsum II. Metode analisis yang digunakan meliputi regresi linier berganda, dan selain itu juga dilakukan pengujian seperti uji kualitas data dan uji asumsi klasik.
Hasil penelitian menunjukkan bahwa variabel sikap mandiri berpengaruh positif dan signifikan terhadap minat berwirausaha. Motivasi berpengaruh positif dan signifikan terhadap minat berwirausaha. Pengetahuan kewirausahaan berpengaruh positif dan signifikan terhadap minat berwirausaha pada UMKM muda yang baru memulai usaha Di Kelurahan Kota Matsum II, Medan di bidang kuliner.
Trigger finger – Poor outcome of surgery associated with younger age, pain, psoriatic arthritis and atopic disease
Authors: Holm Björn , Rönnelid Johan , Baecklund Eva , Wiig Monica 
Published: September 2024

Background: Trigger finger, or stenosing tendovaginitis, is one of the most common causes of hand disability, where a finger or thumb painfully snaps and locks due to a tendon-sheath size mismatch at the A1 pulley. The exact aetiology of trigger finger is unknown, though it is associated with factors like diabetes, rheumatic disease and carpal tunnel syndrome. The main purpose of this prospective study was to explore clinical characteristics and comorbidities in a cohort of 139 patients who underwent surgery for trigger finger and find factors of importance for the outcome 1 year postoperatively.
Methods: Pain, range of motion, hand function evaluated by the Disabilities of the Arm Shoulder and Hand questionnaire as well as Quinnell grade of triggering were examined preoperatively. Symptom duration, working status, medical history and comorbidities at baseline were also noted. Further, range of motion was evaluated 3 months after surgery, pain and hand function were evaluated 3 and 12 months after surgery. An outcome scale with three levels was defined. The development of any new comorbidities was monitored during an extended postoperative observation period, with a mean duration of 70 months (range: 56–88 months).
Results: Poor outcome was strongly associated with younger age (P = 0.0009), a high level of preoperative pain in the operated hand (P = 0.0027), psoriatic arthritis (P = 0.021) and atopic disease (P = 0.028; odds ratio [OR]: 3.87, 95% confidence interval [CI]: 1.15–13.04). A low range of motion preoperatively did not affect the outcome. Carpal tunnel syndrome was the most common comorbidity but did not affect the outcome. A good preoperative range of motion, good hand function and less pain were associated with better outcomes.
Conclusion: Younger age, a high level of preoperative pain, psoriatic arthritis and atopic disease were factors associated with a worse outcome of trigger finger surgery. Pain and disability decreased 3 months postoperatively and continued to decrease between 3 and 12 months.
Assessment of Wet Wipes and their Environmental Significance – A Review Article
Authors: Dwivedi Bhaskar C , Chakraborty Ayan 
Published: September 2024

Nowadays, wet wipes are highly common in the cosmetics market. Also called moist tissues. Its primary function is cleaning. It is a fantastic substitute for traveling with water, soap, and a towel. Wipes are currently a non-woven material with a rapidly rising market. The wipes have a tendency to retain liquid and gather to hold debris, dust, and other cleared particles. Preservatives, water, surfactants, buffers, fragrances, and nutritious components are all combined to make wet wipes. The major disadvantage of wet wipes they are made of synthetic fiber are non biodegradables which lead to microplastic pollution and harsh impact on the human skin, so get ride off these situations wet wipes industry should have to use herbal finished and eco-friendly fibers to make wet wipes for day to-day use. The present paper aims to throw a light on the assessment of the environmental significance of wet wipes.
Cyperus kilelai (Cyperaceae), a new species from a thermal spring in Katanga (Democratic Republic of the Congo)
Authors: Mesterházy Attila , Reynders Marc , Ngoy Shutcha Mylor 
Published: September 2024

Background – During field work performed in 2018 by the University of Lubumbashi in the Katanga region of D.R. Congo, a peculiar Cyperus species was discovered at the edges of a thermal spring in the southwest corner of the Upemba graben, near the city of Luena.
Material and methods – Herbarium material from the collected plant was studied and used as a basis for illustrations and a SEM study of the nutlets. A preliminary IUCN Red List assessment was performed according to the IUCN Guidelines and Criteria.
Results – Cyperus kilelai, a new species from Katanga in D.R. Congo, is described and illustrated. This small tussocky species is characterised by weakly 3–4 angled dimerous nutlets with stigma branches in ad- and abaxial positions and glumes of 2.5–3.2 mm long. It is currently only known from its type location. Thermal springs in this region are of interest for the development of geothermal power plants in the near future. Based on the restricted area, a small population size, and a plausible future threat, the conservation status of this species is preliminarily assessed as Vulnerable.