bluuebunny/crossref_metadata_2025_split huggingface dataset:
LRP6 is identified as a potential prognostic marker for oral squamous cell carcinoma via MALDI-IMS
Authors: Yuan Yao , Xie Xiaoyan , Jiang Yuchen , Wei Zihao , Wang Peiqi , Chen Fangman , Li Xinyi , Sun Chongkui , Zhao Hang , Zeng Xin , Jiang Lu , Zhou Yu , Dan Hongxia , Feng Mingye , Liu Rui , Wang Zhiyong , Chen Qianming 
Published: September 2017

AbstractOral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths worldwide, with 500 000 new cases each year. However, the mechanisms underlying OSCC development are relatively unknown. In this study, matrix-assisted laser desorption ionization imaging mass spectrometry (MALDI-IMS)-based proteomic strategy was used to profile the differentially expressed peptides/proteins between OSCC tissues and their adjacent noncancerous tissues. Sixty-seven unique peptide peaks and five distinct proteins were identified with changed expression levels. Among them, LRP6 expression was found to be upregulated in OSCC tissues, and correlated with a cluster of clinicopathologic parameters, including smoking, drinking, tumor differentiation status, lymph node metastasis and survival time. Notably, knockdown of LRP6 inhibited the proliferation ability of OSCC cells. Furthermore, we demonstrated that the expression of LRP6 in OSCC cells is positively correlated with its downstream oncogene, FGF8. The present study suggests that LRP6 could be a potential biomarker for OSCC patients, and might further assist in the therapeutic decisions in OSCC treatment.
Tailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux disease
Authors: Ranaldo Nunzio , Losurdo Giuseppe , Iannone Andrea , Principi Mariabeatrice , Barone Michele , De Carne Massimo , Ierardi Enzo , Di Leo Alfredo 
Published: September 2017

AbstractA relevant percentage of non-erosive reflux disease (NERD) is refractory to proton pump inhibitors (PPIs) treatment. Multichannel intraluminal impedance pH (MII-pH) monitoring should give useful pathophysiological information about refractoriness. Therefore, our aim was to assess whether this technique could be useful to guide a 'tailored' therapy in refractory NERD. We retrospectively recruited NERD patients undergoing MII-pH monitoring for unsuccessful treatment. All patients had undergone upper endoscopy, and those with erosive esophagitis were excluded. No patient received PPI during MII-pH monitoring. Subjects were subgrouped into three categories: acid reflux, non-acid reflux and functional heartburn. MII-pH-guided therapy was performed for 4 weeks as follows: patients with acid reflux received PPI at double dose, patients with non-acid reflux PPI at full dose plus alginate four times a day and patients with functional heartburn levosulpiride 75 mg per day. A visual analog scale (VAS) ranging from 0 to 100 mm was administered before and after such tailored therapy to evaluate overall symptoms. Responders were defined by VAS improvement of at least 40%. Sixty-nine patients with refractory NERD were selected (female–male ratio 43 : 26, mean age 47.6±15.2 years). Overall effectiveness of tailored therapy was 84% without statistical difference among subgroups (88.5% acid reflux, 92% non-acid reflux, 66.6% functional heartburn; P=0.06). Univariate analysis showed that therapy failure directly correlated with functional heartburn diagnosis (OR=4.60) and suggested a trend toward a negative correlation with smoking and a positive one with nausea. However, at multivariate analysis, these parameters were not significant. Functional heartburn experienced a lower median percent VAS reduction than acid reflux (52.5% versus 66.6%, P<0.01) even if equal to non-acid reflux (66.6%). In conclusion, a tailored approach to refractory NERD, guided by MII-pH monitoring, demonstrated to be effective and should be promising to cure symptom persistence after conventional therapy failure. Nevertheless, standardized guidelines are advisable.
Enhanced Bandwidth of High Directive Emission Fabry-Perot Resonator Antenna with Tapered Near-Zero Effective Index Using Metasurface
Authors: Liu Zhen-Guo , Lu Wei-Bing , Yang Wu 
Published: September 2017

AbstractIn this paper, a novel explanation on high directive emission of Fabry-Perot resonator antenna with subwavelength metasurface is proposed. Based on image theory and effective constitutive parameter retrieval, the whole Fabry-Perot resonant cavity structure composed of a single-layer metasurface with square ring element and a PEC ground plate can be acted as an effective metamaterial media with very low refractive index (near zero index). According to Snell’s theory, this property can be used to enhance the directive emission. Based on this, with tapered size square ring unitcell, the overlapped bandwidth in which the effective refractive index is near to zero is obtained to widen the bandwidth of high directive emission. It is demonstrated that the maximum of directivity is nearly approaching to 19 dBi, and its 3-dB bandwidth can be improved to 19.5%. A final prototype has been fabricated and measured to validate the proposed design concept. The measured 3-dB gain bandwidth is approximately 20.3% with a peak gain of 17.9 dBi. These results indicate the feasibility of such kind of antenna for broadband and high directivity applications simultaneously.
Changing smoking-mortality association over time and across social groups: National census-mortality cohort studies from 1981 to 2011
Authors: Teng Andrea , Atkinson June , Disney George , Wilson Nick , Blakely Tony 
Published: September 2017

AbstractThe difference in mortality between current and never-smokers varies over time, affecting future projections of health gains from tobacco control. We examine this heterogeneity by sex, ethnicity and cause of death on absolute and relative scales using New Zealand census data. These data included smoking status, and were linked to subsequent mortality records in 1981–84, 1996–99 and 2006–11 for 25–74 year olds (16.1 million person-years of follow-up). Age-standardised mortality rates and rate differences (SRDs) were calculated comparing current to never-smokers, and Poisson regression was used to adjust for multiple socioeconomic factors and household smoking. We found that mortality declined over time in never-smokers; however, mortality trends in current-smokers varied by sex, ethnicity and cause of death. SRDs were stable over time in European/Other men, moderately widened in European/Other women and markedly increased in Māori men and women (Indigenous population). Poisson smoking-mortality rate ratios (RRs) increased from 1981–84 to 1996–99 with a moderate increase from 1996–99 to 2006–11 (RRs 1.48, 1.77, 1.79 in men and 1.51, 1.80, 1.90 in women). Socioeconomic confounding increased over time. In summary, this marked heterogeneity in smoking-mortality RRs over time has implications for estimating the future health and inequality impacts of tobacco control interventions.
Membership‐Function‐Dependent Stability Analysis of Interval Type‐2 Polynomial Fuzzy‐Model‐Base Control Systems
Authors: Song Ge , Lam Hak‐Keung , Yang Xiaozhan 
Published: September 2017

In this paper, the stability analysis for interval type‐2 (IT2) polynomial fuzzy‐model‐based (PFMB) control system using the information of membership functions is investigated. To tackle uncertainties, IT2 membership functions are used in the IT2 polynomial fuzzy model and IT2 polynomial fuzzy controller. The stability of IT2 PFMB control system is investigated based on the Lyapunov stability theory and both sets of membership function independent (MFI) and membership function dependent (MFD) stability conditions are derived on the basis of the sum‐of‐squares (SOS) approach. To make the stability conditions MFD, the boundary information of IT2 membership functions is used in the stability analysis. To extract richer information of IT2 membership functions, the operating domain is partitioned into sub‐domains. In each sub‐domain, the boundary information of IT2 membership functions and those of the upper and lower membership function are obtained. Furthermore, to further relax the conservativeness, a switching polynomial fuzzy controller, together with the informations obtained in each sub‐domain, is employed in investigating the stability analysis. Numerical examples and simulation results are given to demonstrate the validity of MFD and MFD switching methods.
Was gibt’s zu essen?
Authors: Schmidt Maximilian 
Published: September 2017

Zusammenfassung
Ernährung Immer mehr ältere und multimorbide Patienten werden auf unseren Intensivstationen versorgt. Die richtige Ernährung besonders
bei geriatrischen Intensivpatienten gewinnt zukünftig an Relevanz und zwingt Krankenhäuser dazu, sich intensiver mit dem Thema zu
beschäftigen. Besonders die häufig bereits bestehende Mangelernährung eines auf der Intensivstation eingelieferten Patienten sorgt für einen
schwereren Verlauf der Erkrankung. Damit verbunden sind längere Liegezeiten und höhere Sterberaten.
Liquid and Vapor-Phase Activity of Artemisia annua Essential Oil against Pathogenic Malassezia spp.
Authors: Santomauro Francesca , Donato Rosa , Pini Gabriella , Sacco Cristiana , Ascrizzi Roberta , Bilia Anna 
Published: September 2017

Abstract
Artemisia annua essential oil has given us many encouraging results for its numerous antimicrobial properties. In this study, the essential oil, both in liquid and in vapor phases, was tested against various Malassezia species closely related to many skin disorders in humans and animals. Malassezia treatment and eradication are mainly based on old azole drugs, which are characterized by poor compliance, unpredictable clinical efficacy, emerging resistance, and several side effects. Monoterpenes (ca. 88%) represent the most abundant group of compounds in the essential oil, mainly the oxygenated derivatives (ca. 74%) with camphor (25.2%), 1,8-cineole (20%), and artemisia ketone (12.5%). In vapor phase, monoterpenes represent more than 98% of the constituents, α-pinene being the main constituent (22.8%), followed by 1,8-cineole (22.1%) and camphene (12.9%). Essential oil of A. annua, both in vapor phase and liquid, showed strong antimicrobial activity towards almost the tested twenty strains of Malassezia analyzed. The minimum fungicidal concentrations from most of the strains tested were from 0.78 µL/mL to 1.56 µL/mL, and only three strains of Malassezia sympodialis required a higher concentration of 3.125 µL/mL. Overall, the minimal inhibitor concentrations obtained by vapor diffusion assay were lower than those obtained by the liquid method. The average values of minimal inhibitor concentrations obtained by the two methods at 72 h are 1.3 – 8.0 times higher in liquid compared to those in the vapor phase.
Multi-band photometry of trans-Neptunian objects in the Subaru Hyper Suprime-Cam survey
Authors: Terai Tsuyoshi , Yoshida Fumi , Ohtsuki Keiji , Lykawka Patryk Sofia , Takato Naruhisa , Higuchi Arika , Ito Takashi , Komiyama Yutaka , Miyazaki Satoshi , Wang Shiang-Yu 
Published: September 2017

Abstract
We present visible multi-band photometry of trans-Neptunian objects (TNOs) observed by the Subaru Telescope in the framework of the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) from 2014 March to 2016 September. We measured the five broad-band (g, r, i, z, and Y) colors over the wavelength range from 0.4 μm to 1.0 μm for 30 known TNOs using the HSC-SSP survey data covering ∼500 deg2 of sky within ±30° of ecliptic latitude. This dataset allows us to investigate the correlations between the dynamical classes and visible reflectance spectra of TNOs. Our results show that the hot classical and scattered populations with orbital inclination (I) of I ≳ 6° share similar color distributions, while the cold classical population with I ≲ 6° has a different color distribution from the others. The low-I population has reflectance increasing toward longer wavelengths up to ∼0.8 μm, with a steeper slope than the high-I population at ≲ 0.6 μm. We also find a significant anti-correlation between g − r/r − i colors and inclination in the high-I population, as well as a possible bimodality in the g − i color vs. eccentricity plot.
Safety of Medical Abortion Provided Through Telemedicine Compared With In Person
Authors: Grossman Daniel , Grindlay Kate 
Published: September 2017

OBJECTIVE:
To compare the proportion of medical abortions with a clinically significant adverse event among telemedicine and in-person patients at a clinic system in Iowa during the first 7 years of the service.

METHODS:
We conducted a retrospective cohort study. We analyzed data on clinically significant adverse events (hospital admission, surgery, blood transfusion, emergency department treatment, and death) for all medical abortions performed by telemedicine or in person at a clinic system in Iowa between July 1, 2008, and June 30, 2015. Data on adverse events came from required reporting forms submitted to the mifepristone distributor. We calculated the prevalence of adverse events and 95% CIs comparing telemedicine with in-person patients. The analysis was designed as a noninferiority study. Assuming the prevalence of adverse events to be 0.3%, telemedicine provision was considered to be inferior to in-person provision if the prevalence were 0.6% or higher. The required sample size was 6,984 in each group (one-sided α=0.025, power 90%). To explore whether patients with adverse events presented to emergency departments and were not reported, we conducted a survey of the 119 emergency departments in Iowa, asking whether they had treated a woman with an adverse event in the prior year.

RESULTS:
During the study period, 8,765 telemedicine and 10,405 in-person medical abortions were performed. Forty-nine clinically significant adverse events were reported (no deaths or surgery; 0.18% of telemedicine patients with any adverse event [95% CI 0.11–0.29%] and 0.32% of in-person patients [95% CI 0.23–0.45%]). The difference in adverse event prevalence was 0.13% (95% CI −0.01% to 0.28%, P=.07). Forty-two emergency departments responded to the survey (35% response rate); none reported treating a woman with an adverse event after medical abortion.

CONCLUSION:
Adverse events are rare with medical abortion, and telemedicine provision is noninferior to in-person provision with regard to clinically significant adverse events.
A Brief Prenatal Intervention of Behavioral Change to Reduce the Risk of Maternal Cytomegalovirus
Authors: Hughes Brenna L. , Gans Kim M. , Raker Christina , Hipolito Evelyn R. , Rouse Dwight J. 
Published: September 2017

OBJECTIVE:
To estimate the effects of a brief prenatal behavioral intervention on risk behaviors for maternal cytomegalovirus (CMV) infection.

METHODS:
Women were screened with CMV serology during prenatal care before 20 weeks of gestation and followed for at least 10 weeks. Women without serologic evidence of primary CMV infection were approached. Participants were apprised of serostatus and then randomized 2:1 to either a brief behavioral intervention during their prenatal care visit or to standard care (a brochure). The 7- to 10-minute in-office intervention included a video and hygiene education using motivational interviewing. Participants were then given a reminder calendar to take home and weekly text message reminders. The primary outcome was change in behavioral compliance score on a scale of 0–100. Secondary outcomes included process evaluation and domains of behavior change. A sample size of 180 participants was planned to compare the behavioral compliance score change of at least 15% between intervention and control groups with 80% power and 2.5% two-sided α.

RESULTS:
From April 2013 to October 2014, 197 women were randomized. One hundred eighty-seven (96%) had outcome data available. Mean gestational age at screening and randomization was 9 4/7 and 13 6/7 weeks of gestation, respectively. Primary outcome assessment occurred at a mean of 28 4/7 weeks of gestation. Baseline behavioral compliance scores increased modestly in the intervention group (mean: 7-point increase from 80.7 to 87.7, 95% CI 2.4–5.9) compared with the comparison group (mean: 4-point increase from 79.7 to 84.1, 95% CI 5.9–8.4; mean difference in change score: 3.0, 95% CI, 0.8–5.2; P=.007). Those in the intervention group reported change in risk perception related to perceived severity and susceptibility, self-efficacy, and perceived norms (P<.05 for all).

CONCLUSION:
A brief behavioral intervention delivered in the prenatal care setting was modestly effective at changing behaviors related to CMV infection risk.

CLINICAL TRIAL REGISTRATION:

ClinicalTrials.gov, NCT01819519.
Reducing False-Positive Pregnancy Test Results in Patients With Cancer
Authors: McCash Samuel I. , Goldfrank Deborah J. , Pessin Melissa S. , Ramanathan Lakshmi V. 
Published: September 2017

OBJECTIVE:
To assess whether the use of a laboratory test specific for intact human chorionic gonadotropin (hCG) would reduce the number of false-positive pregnancy test results.

METHODS:
From October 21, 2014, to January 20, 2015, and April 1, 2015, to June 2, 2015, all serum samples sent for pregnancy screening at a large cancer center with a value of 5 milli-international units/mL or greater total β-hCG were frozen and stored and then retested using intact hCG reagent. We compared the accuracy of total β-hCG and intact hCG results for the diagnosis of clinically confirmed pregnancy. A negative test was defined as 14 milli-international units/mL or less, our current institutional cutoff. We also assessed a cutoff of less than 5 milli-international units/mL, a historical cutoff to rule out pregnancy.

RESULTS:
We performed intact hCG testing on 64 patient samples, of which 34 had originally resulted positive when tested for total β-hCG. These included 21 cases of clinically confirmed pregnancy and 13 false-positive cases. No women were pregnant when their intact hCG concentration was 14 milli-international units/mL or less, and all pregnancies were detected at and above this concentration. Intact hCG reduced the number of false-positive pregnancy test results from 13 to 1, a 92% reduction (95% CI 64–99%), corresponding to a reduction in the false-positive rate from 38% (95% CI 22–56%) to 3% (95% CI 1–15%).

CONCLUSION:
The use of intact hCG reagent in patients with cancer reduces the rate of false-positive pregnancy test results without increasing the rate of false-negative test results.
Aggressive Angiomyxoma of the Vulva and Bladder
Authors: Song Mihae , Glasgow Michelle , Murugan Paari , Rivard Colleen 
Published: September 2017

BACKGROUND:
Aggressive angiomyxoma is a rare, locally infiltrative tumor, frequently occurring in female patients. Although wide local excision is considered standard therapy, radical surgery may be needed.

CASE:
A 49-year-old woman presented with an aggressive angiomyxoma involving the vulva and bladder. Given the hormone receptor status and size of the tumor, the patient was initially treated with fulvestrant and goserelin acetate in an attempt to reduce the size of the mass. She was followed up at 1- to 3-month intervals; after 6 months of treatment, owing to increasing size of the mass and worsening symptoms, the decision was made to proceed with radical surgery.

CONCLUSION:
Although a less radical surgical approach is preferred, radical surgery is possible for treatment of aggressive angiomyxoma when needed.
Geographic Comparison of Women in Academic Obstetrics and Gynecology Department-Based Leadership Roles
Authors: Ricciotti Hope A. , Dodge Laura E. , Aluko Ashley , Hofler Lisa G. , Hacker Michele R. 
Published: September 2017

OBJECTIVE:
To describe and compare geographic representation of women in obstetrics and gynecology department-based leadership roles across American Congress of Obstetricians and Gynecologists (ACOG) districts and U.S. Census Bureau regions while accounting for the proportion of women practicing in each area.

METHODS:
We conducted a cross-sectional observational study. To more meaningfully quantify representation of women as leaders in ACOG districts and U.S. Census Bureau regions, we calculated representation ratios—the proportion of department-based leaders who were women divided by the proportion of obstetrician–gynecologists who were women. A ratio of 1.0 indicates proportionate representation and less than 1.0 indicates underrepresentation. We calculated 95% CIs to compare representation of women in leadership roles across geographic areas. The gender of major department-based leaders (chair, vice chair, division director) and educational leaders (fellowship, residency, associate residency, medical student clerkship director) was determined from websites.

RESULTS:
The proportion of department chairs who were women was highest in the West and lowest in the South Census Bureau regions. Representation ratios for women in major department-based leadership roles demonstrated underrepresentation relative to the practicing base nationally and in all four regions. Although women were underrepresented in major department-based leadership throughout the country, there was significantly higher women's representation in major department-based leadership roles in the West (ratio 0.82, 95% CI 0.68–0.99) compared with the Northeast (ratio 0.50, 95% CI 0.42–0.59) and the South (ratio 0.45, 95% CI 0.36–0.57). Similarly, in the division director role, the West (ratio 0.85, 95% CI 0.68–1.1) had significantly higher representation of women compared with the Northeast (ratio 0.50, 95% CI 0.40–0.62). Nationally, women were underrepresented as fellowship directors, proportionately represented as residency program directors, and overrepresented as medical student clerkship directors.

CONCLUSION:
Representation ratios of women in major department-based leadership roles, which account for the proportion of women practicing in each geographic area, suggest that women were more likely to advance to the department-based leadership roles of chair, vice chair, or division director in the western United States.