bluuebunny/crossref_metadata_2025_split huggingface dataset:
Validation of an ‘endovascular-first’ approach to spinal dural arteriovenous fistulas: an intention-to-treat analysis
Authors: Gross Bradley A , Albuquerque Felipe C , Moon Karam , McDougall Cameron G 
Published: March 2016

Background/objectiveSpinal dural arteriovenous fistulas (SDAVFs) require pretreatment angiography; embolization can be performed in the same session. To validate this approach, obliteration and morbidity rates of ‘endovascular-first’ (embolization and microsurgery in the case of embolization failures) must be compared with rates for ‘microsurgery-first’ (microsurgical ligation without attempted embolization) approaches.MethodsWe reviewed our institutional database (January 1998–October 2015) for SDAVFs, performing an intention-to-treat analysis comparing endovascular-first and microsurgery-first approaches.ResultsA total of 71 patients underwent surgical and/or endovascular treatment for SDAVFs. All SDAVFs were ultimately occluded. Of 35 patients under consideration for an endovascular-first approach, radicular artery anatomy or anterior spinal artery embolization risk precluded attempting embolization in seven cases (20%). Among 28 patients undergoing embolization, angiographic non-opacification of the fistula was noted in 18 (64%). Fourteen patients had obliteration with excellent casting of the draining vein (50%) and did not undergo surgery. There were no significant differences in total complications (9% vs 11%; p=1.0) or permanent complications (3% vs 4%; p=1.0) after attempted endovascular and surgical treatment. Based on an intention-to-treat analysis, there were no significant differences in total complications (11% vs 14%; p=1.0), permanent complications (6% vs 3%; p=0.61), or the symptomatic resolution/improvement rate (80% vs 78%; p=1.0) between endovascular-first and microsurgery-first groups.ConclusionsOur results support attempted embolization of SDAVFs prior to consideration of microsurgery, allowing for a less invasive treatment option in the same session as diagnostic angiography.
Long-term survival after surgical aortic valve replacement among patients over 65 years of age
Authors: Sharabiani Mansour T A , Fiorentino Francesca , Angelini Gianni D , Patel Nishith N 
Published: March 2016

ObjectiveSurgical aortic valve replacement (AVR) remains the gold standard therapy for severe aortic stenosis. Long-term survival data following AVR is required. Our objective was to provide a detailed contemporary benchmark of long-term survival following AVR among elderly patients (≥65 years) in the UK.MethodsWe conducted a retrospective cohort study of 1815 adult patients undergoing surgical AVR± coronary artery bypass graft (CABG) surgery at a single UK centre between 1996 and 2011. Our main outcome was patient survival, which was assessed by linkage to census records at the Office for National Statistics.ResultsThe mean age of the cohort was 75 (±5.6) years. Patients in the AVR alone group had a slightly higher median survival of 10.9 (95% CI 10.5 to 11.8) years than the AVR+CABG group which had a median survival of 9.6 (95% CI 8.7 to 10.1) years (p=0.001 of log-rank test (LRT) for equality of survivor functions). The presence of chronic kidney disease, severely impaired left ventricular function or being a current smoker were each associated with a ≥50% increased risk of long-term mortality. Comparison of our study cohort patients and the reference (operation year, age and gender matched) UK population suggested no difference in survival probability up to 8 years (p=0.55). However, for longer periods of follow-up, the difference became increasingly significant (p<0.0001).ConclusionsLong-term survival following surgical AVR in patients over 65 years of age is excellent and up to 8 years is comparable to the matched general population.
Graphic warning labels and the demand for cigarettes
Authors: Starr Martha A , Drake Keith 
Published: March 2016

BackgroundIn 2010, the US Food and Drug Administration (FDA) proposed requiring tobacco companies to add graphic warning labels (GWLs) to cigarette packs. GWLs are large prominently placed warnings that use both text and photographic images to depict health risks of smoking. The companies challenged FDA's authority on First Amendment grounds; the courts accepted that FDA could compel companies to add GWLs, but argued that FDA had not established that GWLs would significantly reduce smoking.ObjectiveThis paper adds new evidence on the question of whether GWLs would have reduced cigarette demand, by examining whether tobacco companies’ share prices fell unusually after news indicating a higher likelihood of having GWLs, and rose on the opposite news. Such findings would be expected if investors viewed GWLs as likely to reduce cigarette demand.MethodsAn event-study approach is used to determine whether the stock prices of US tobacco companies rose or fell unusually after news events in the period when GWLs were proposed, finalised, challenged and withdrawn.FindingsTobacco companies’ stock prices indeed realised significant abnormal returns after GWL news, consistent with expected negative effects on cigarette demand. Our estimates suggest investors expected GWLs to reduce the number of smokers by an extra 2.4–6.9 million in the 10 years after the rule took effect.ConclusionsThese findings support the view that the GWLs proposed by FDA would have curbed cigarette consumption in the USA in an appreciable way.
The use of chemostratigraphy to refine ambiguous sequence stratigraphic correlations in marine mudrocks. An example from the Woodford Shale, Oklahoma, USA
Authors: Turner B. W. , Tréanton J. A. , Slatt R. M. 
Published: March 2016

Application of sequence stratigraphy to fine-grained lithologies has previously been hindered by the difficulty of identifying distinct facies shifts within mudrocks. Three cores from Lincoln, Pottawatomie and Pontotoc Counties in Oklahoma and two outcrops at the Hunton Anticline Quarry in Murray County, OK record both proximal and distal regions of the Arkoma Basin. Handheld X-ray fluorescence data and gamma-ray profiles together with lithological descriptions can be used to develop sequence-stratigraphic interpretations.
Stratigraphic successions that are challenging to correlate based on gamma-ray (GR) profiles alone can be correlated accurately by utilizing surfaces that are recognized within chemostratigraphic profiles. Within the Arkoma Basin, Oklahoma, the chemostratigraphic profile of the Woodford Shale is interpreted within a sequence-stratigraphic framework using the following general criteria. The Lowstand Systems Tract (LST) is defined by increasing concentrations of Ti, Zr, Al and K as well as high levels of Mo and V. The Transgressive Systems Tract (TST) is defined by declining concentrations of Ti and Zr, although Al and K may remain elevated; Mo and V also show general declines. The Highstand Systems Tract (HST) is defined by increasing concentrations of Ti, Zr, Al and K, but is distinguished from the LST by low levels of Mo and V.

Supplementary material:
Chemofacies profiles are available at
http://doi.org/10.6084/m9.figshare.c.2849599
.
APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma
Authors: Leonard Brandon , Starrett Gabriel J. , Maurer Matthew J. , Oberg Ann L. , Van Bockstal Mieke , Van Dorpe Jo , De Wever Olivier , Helleman Jozien , Sieuwerts Anieta M. , Berns Els M.J.J. , Martens John W.M. , Anderson Brett D. , Brown William L. , Kalli Kimberly R. , Kaufmann Scott H. , Harris Reuben S. 
Published: March 2016

Abstract
Purpose: APOBEC3 DNA cytosine deaminase family members normally defend against viruses and transposons. However, deregulated APOBEC3 activity causes mutations in cancer. Because of broad expression profiles and varying mixtures of normal and cancer cells in tumors, including immune cell infiltration, it is difficult to determine where different APOBEC3s are expressed. Here, we ask whether correlations exist between APOBEC3 expression and T-cell infiltration in high-grade serous ovarian cancer (HGSOC), and assess whether these correlations have prognostic value.
Experimental Design: Transcripts for APOBEC3G, APOBEC3B, and the T-cell markers, CD3D, CD4, CD8A, GZMB, PRF1, and RNF128 were quantified by RT-qPCR for a cohort of 354 HGSOC patients. Expression values were correlated with each other and clinical parameters. Two additional cohorts were used to extend HGSOC clinical results. Immunoimaging was used to colocalize APOBEC3G and the T-cell marker CD3. TCGA data extended expression analyses to additional cancer types.
Results: A surprising positive correlation was found for expression of APOBEC3G and several T cell genes in HGSOC. Immunohistochemistry and immunofluorescent imaging showed protein colocalization in tumor-infiltrating T lymphocytes. High APOBEC3G expression correlated with improved outcomes in multiple HGSOC cohorts. TCGA data analyses revealed that expression of APOBEC3D and APOBEC3H also correlates with CD3D across multiple cancer types.
Conclusions: Our results identify APOBEC3G as a new candidate biomarker for tumor-infiltrating T lymphocytes and favorable prognoses for HGSOC. Our data also highlight the complexity of the tumor environment with respect to differential APOBEC family gene expression in both tumor and surrounding normal cell types. Clin Cancer Res; 22(18); 4746–55. ©2016 AACR.
Dual Faces of IFNγ in Cancer Progression: A Role of PD-L1 Induction in the Determination of Pro- and Antitumor Immunity
Authors: Mandai Masaki , Hamanishi Junzo , Abiko Kaoru , Matsumura Noriomi , Baba Tsukasa , Konishi Ikuo 
Published: March 2016

AbstractIFNγ is a cytokine that plays a pivotal role in antitumor host immunity. IFNγ elicits potent antitumor immunity by inducing Th1 polarization, CTL activation, and dendritic cell tumoricidal activity. However, there are significant discrepancies in our understanding of the role of IFNγ as an antitumor cytokine. In certain circumstances, IFNγ obviously acts to induce tumor progression. IFNγ treatment has negatively affected patient outcomes in some clinical trials, while it has favorably affected outcomes in other trials. Several mechanisms, including IFNγ insensitivity and the downregulation of the MHC complex, have been regarded as the reasons for this discrepancy, but they do not fully explain it. We propose IFNγ-induced programmed cell death 1 ligand 1 (PD-L1) expression as a novel mechanism by which IFNγ impairs tumor immunity. When tumor cells encounter CTLs in the local environment, they detect them via the high concentration of IFNγ secreted from CTLs, which induces PD-L1 expression in preparation for an immune attack. Thus, tumor cells acquire the capability to counterattack immune cells. These findings indicate that although IFNγ is thought to be a representative antitumor cytokine, it actually has dual roles: one as a hallmark of antitumor immunity and the other as an inducer of the immune escape phenomenon through various mechanisms, such as PD-L1 expression. In this context, the optimization of immunotherapy according to the local immune environment is important. Anti–PD-1/PD-L1 treatment may be particularly promising when efficient tumor immunity is present, but it is disturbed by PD-L1 expression. Clin Cancer Res; 22(10); 2329–34. ©2016 AACR.
DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia
Authors: Meyer Sara E. , Qin Tingting , Muench David E. , Masuda Kohei , Venkatasubramanian Meenakshi , Orr Emily , Suarez Lauren , Gore Steven D. , Delwel Ruud , Paietta Elisabeth , Tallman Martin S. , Fernandez Hugo , Melnick Ari , Le Beau Michelle M. , Kogan Scott , Salomonis Nathan , Figueroa Maria E. , Grimes H. Leighton 
Published: March 2016

Abstract
Cytogenetically normal acute myeloid leukemia (CN-AML) represents nearly 50% of human AML. Co-occurring mutations in the de novo DNA methyltransferase DNMT3A and the FMS related tyrosine kinase 3 (FLT3) are common in CN-AML and confer a poorer prognosis. We demonstrate that mice with Flt3-internal tandem duplication (Flt3ITD) and inducible deletion of Dnmt3a spontaneously develop a rapidly lethal, completely penetrant, and transplantable AML of normal karyotype. AML cells retain a single Dnmt3a floxed allele, revealing the oncogenic potential of Dnmt3a haploinsufficiency. FLT3ITD/DNMT3A-mutant primary human and murine AML exhibit a similar pattern of global DNA methylation associated with changes in the expression of nearby genes. In the murine model, rescuing Dnmt3a expression was accompanied by DNA remethylation and loss of clonogenic potential, suggesting that Dnmt3a-mutant oncogenic effects are reversible. Dissection of the cellular architecture of the AML model using single-cell assays, including single-cell RNA sequencing, identified clonogenic subpopulations that express genes sensitive to the methylation of nearby genomic loci and responsive to DNMT3A levels. Thus, Dnmt3a haploinsufficiency transforms Flt3ITD myeloproliferative disease by modulating methylation-sensitive gene expression within a clonogenic AML subpopulation.
Significance: DNMT3A haploinsufficiency results in reversible epigenetic alterations that transform FLT3ITD-mutant myeloproliferative neoplasm into AML. Cancer Discov; 6(5); 501–15. ©2016 AACR.
This article is highlighted in the In This Issue feature, p. 461
Modeling and Simulation of MPPT-SEPIC Combined Bidirectional Control Inverse KY Converter Using ANFIS in Microgrid System
Authors: Soedibyo Soedibyo , Murdianto Farid Dwi , Suyanto Suyanto , Ashari Mochamad , Penangsang Ontoseno 
Published: March 2016

<em>Photovoltaic system (PV) is widely used in various renewable energy application. The main problem of PV system is how to get the maximum output power which is integrated in microgrid system. Furthermore, the redundancy output power generated by on a distribution system should also be considered. This study utilizes the excess power for energy storage using bidirectional of KY inverse</em> <em>converter. Since the DC voltage which generated by PV and the energy storage will be converted into AC voltage using inverter toward load. This paper proposes ANFIS as search optimization method using SEPIC converter with a maximum efficiency of 99.95%</em> to impact to power generation performance in microgrid system.
Noise Uncertainty Effect on a Modified Two-Stage Spectrum Sensing Technique
Authors: A.Tag El-Dien Heba , M. Zaki Rokaia , M. Tantawy Mohsen , M. Abdel-Kader Hala 
Published: March 2016

Detecting the presence or absence of primary user is the key task of cognitive radio networks. However, relying on single detector reduces the probability of detection and increases the probability of missed detection. Combining two conventional spectrum sensing techniques by integrating their individual features improves the probability of detection especially under noise uncertainty. This paper introduces a modified two-stage detection technique that depends on the energy detection as a first stage due to its ease and speed of detection, and the proposed Modified Combinational Maximum-Minimum Eigenvalue based detection as a second stage under noise uncertainty and comperes it with the case of using Maximum-Minimum Eigenvalue and Combinational Maximum-Minimum Eigenvalue as a second stage.
Designing Game-Based Service Desk towards User Engagement Improvement
Authors: Surendro Kridanto , Putri Raflesia Sarifah 
Published: March 2016

<p>Along the implementation of Information Technology (IT), there are incident, request, problem, and event. According to this, organizations need to implement a function which can be a single point to provide communication between IT service provider and IT users. Information Technology Infrastructure Library (ITIL) mentions service desk as a function to operate solution of this matter. But, recently organizations find new challenge which is related to service desk staffs’ motivation. The repeated activities which are run by service desk may cause saturation. This situation will affect workplace enviroment and productivity. In this research, we propose a design to help organization build game-like activities as solution to boost service desk’s motivation which can give good impact to service desk’s quality. Our proposed design uses game approach and ITIL practices to ensure that game-based service desk is well designed.</p>
An assessment of bryozoan (Phylactolaemata) fauna of Kagzipura Lake, Aurangabad, Maharashtra, India
Authors: Swami Pavan S. , Harkal Ananta D. , Mokashe Satish S. 
Published: March 2016

Freshwater Bryozoa is one of the less explored or ignored animal groups from India. Kagzipura Lake, a rainwater fed water body was surveyed for three years to understand the diversity and distribution of bryozoan fauna. The present study depicts four Phylactolaemata bryozoans species as Rumarcanella vorstmani, Plumatella casmiana, Lophopodella carteri and Swarupella divina. The manuscript provides brief descriptions of these species, photomicrographs of statoblasts using scanning electron microscopy and colony characteristics.
Rhizosphere and non-rhizosphere mycoflora of two ferns from Panhala Fort, Kolhapur, Maharashtra, India
Authors: Hande P. R. , Dongare M. M. 
Published: March 2016

Hypodematium crenatum (Forssk.) Kuhn and Anogramma leptophylla (L.) Link are threatened fern species from Western Ghats. The present paper endorses the preliminary study on mycoflora associated with these ferns. Eighteen fungal species have been isolated from rhizosphere and non-rhizosphere soils of selected ferns. More diversity of fungi was observed in non-rhizosphere as compared to rhizosphere soils of both the ferns. Aspergillus was found to be the most dominant genus among the population followed by Penicillium. Higher percentage of fungal species is shown by H. crenatum, i.e., 44.5% in non-rhizosphere and 27.77% in rhizosphere; while a lower percentage of fungal species was found in A. leptophylla, i.e., 38.88% in non-rhizosphere and 16.66% in rhizosphere. Number of colony forming units per gram soil was more in non-rhizosphere of A. leptophylla while it was less in non-rhizosphere of H. crenatum. Inhibitory rhizosphere effect was exerted by A. leptophylla while H. crenatum has stimulatory effect on soil fungi.
Stahlianthus involucratus (King ex Baker) Craib ex Loes.: a new record to the flora of Mizoram, India
Authors: Rathi Ranbir Singh , Pradheep Kanakasabhapathi , Roy Somnath , Singh Sanjeev Kumar , Misra Anup Kumar 
Published: March 2016

The botanical study of a germplasm, looking similar to Curcuma species and originally collected from the wild in Kolasib District of Mizoram, at the field genebank of ICAR-NBPGR Regional Station, Shillong, led to its confirmation and authentication as Stahlianthus involucratus (King ex Baker) Craib ex Loes. Earlier, this taxon had been reported from the states of Assam, Meghalaya, Nagaland and West Bengal (Darjeeling) in India; this report indicates its distribution in Mizoram also. Its description, phenology, habitat and other field notes, and usefulness have been highlighted here.
Description of a new species of the genus Litus Haliday (Hymenoptera: Chalcidoidea: Mymaridae) from India
Authors: Rehmat Tabassum , Anis Shoeba Binte 
Published: March 2016

A new species of the genus Litus Haliday (Chalcidoidea: Mymaridae), Litus assamensis sp. nov., is described from Assam, India. A key to the Indian species of the genus is also given.
Some new records of plants from the state of Rajasthan, India
Authors: Tiwari Umeshkumar L , Ravikumar Kaliamoorthy , Balachandran Natesan , Sharma Satish K. 
Published: March 2016

A brief note on the distribution of vascular plants new to Rajasthan is presented in this paper. A further distributional expansion and new record of Commicarpus boissieri, Geodorum recurvum, Maytenus senegalensis, Premna resinosa and Solanum elaeagnifolium for the state of Rajasthan is reported.
Distribution, habitat utilisation and conservation status of the freshwater crab, Somanniathelphusa zanklon Ng & Dudgeon, 1992 (Crustacea: Brachyura: Gecarcinucidae) endemic to Hong Kong
Authors: Stanton David J. , Leven Michael R. 
Published: March 2016

Somanniathelphusa zanklon Ng & Dudgeon, 1992 is a tropical freshwater crab currently considered endemic to Hong Kong. The present study shows that S. zanklon has been found in a variety of lotic and lentic habitats, mostly lowland, slow moving streams and marshes. The species is more widely distributed than previously known, and potentially occurs outside Hong Kong. However, its habitat is under threat from development and channelization of watercourses. The life cycle of the crab requires both slow moving streams and marshes for adults and adjacent terrestrial habitats for brooding females, highlighting the need for integrated conservation of lowland streams and their riparian corridors. It is hoped that understanding of the species habitat requirements will encourage others to further explore lowland watercourses in the Pearl River Delta and aid in habitat conservation.
Channa pardalis, a new species of snakehead (Teleostei: Channidae) from Meghalaya, northeastern India
Authors: Knight J.D. Marcus 
Published: March 2016

Channa pardalis, a new species of snakehead, is described from Khasi Hills, Meghalaya, northeastern India. This species can be distinguished from its congeners by a unique colour pattern consisting of numerous large black spots on the post-orbital region of the head, opercle and body; a broad white and black margin to the dorsal, anal and caudal fins; 36–37 dorsal fin rays; 24–25 anal fin rays; 44–45 pored scales on the body and two scales on the caudal fin base; 4½ scales above lateral line and 6½ scales below lateral line; 45 vertebrae and the palatine with two rows of teeth: outer row with numerous minute teeth and inner row with short, stout inward curved teeth.
Moist temperate forest butterflies of western Bhutan
Authors: Singh Arun P. 
Published: March 2016

Random surveys were carried out in moist temperate forests (1,860–3,116 m) around Bunakha Village and Dochula Pass, near Thimphu in western Bhutan, recording 65 species of butterflies. Of these, 11 species, viz., Straightwing Blue Orthomiella pontis pontis Elwes, Slate Royal Maneca bhotea bhotea Moore, Dull Green Hairstreak Esakiozephyrus icana Moore, Yellow Woodbrown Lethe nicetas Hewitson, Small Silverfork Zophoessa jalaurida elwesi Moore, Scarce Labyrinth, Neope pulahina (Evans), Chumbi Wall Chonala masoni Elwes, Pale Hockeystick Sailer Neptis manasa manasa Moore and White Commodore Parasarpa dudu dudu Westwood, are restricted to the eastern Himalaya, northeastern India and Myanmar. Two other species, Tawny Mime Chiasa agestor agestor (Gray) and Himalayan Spotted Flat Celaenorrhinus munda Moore have been only rarely recorded from Bhutan and a few individuals of the rare Bhutan Glory Bhutanitis lidderdalei Atkinson were also recorded near Bunakha.
Publishing trends for the Cycadales, the most threatened plant group
Authors: Cascasan April N. , Marler Thomas E. 
Published: March 2016

Trends in published cycad research within various fields of study were determined using proceedings from international conferences on cycad biology and Google Scholar to access the primary literature. Both search methods indicated that phylogeny, systematics and ecology are strongly represented in recent cycad literature, while there is a need for more research in horticulture and pathology, reviews and clarification of correspondence between current and discontinued species designations.