bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chlorine Dioxide Sterilization of Bulk Aseptic Storage Tanks
Authors: Morgan Mark , Burke Michael 
Published: January 2018

Chlorine dioxide (ClO2) is an antimicrobial pesticide recognized for its disinfectant properties since the early 1900’s. Antimicrobial pesticides are substances used to control harmful microorganisms including bacteria, viruses or fungi on inanimate objects and surfaces. In 1967, EPA first registered the liquid form of chlorine dioxide for use as a disinfectant and sanitizer. In 1988, EPA registered chlorine dioxide gas as a sterilant.
Enerfab and Purdue University began studying the efficacy of using chlorine dioxide gas to sterilize the surfaces of produce in 1996. During this process, Enerfab and Purdue determined that chlorine dioxide gas could potentially be used as an alternative to the traditional method of flood sterilizing bulk aseptic storage tanks with iodophor.
This paper outlines the research that has been performed to develop chlorine dioxide gas sterilization of bulk storage tanks with chlorine dioxide, the efficacy of this method of sterilization, the benefits of its use, and the current status.
Paper published with permission.
Benefits and Techniques for Machine Condition Monitoring in Industrial Environments
Authors: Denton Michael 
Published: January 2018

Condition monitoring of plant machinery is becoming more common place. With new advanced signal processing algorithms and better machine life models proactive maintenance of citrus processing machinery allows avoiding unplanned downtime and catastrophic failure. It also avoids relying only on predictions and assuming the machine will break. This paper will discuss the main steps that are necessary in developing a plant machinery maintenance system and make a business case for implementing machine monitoring on a wide range of plant equipment.
Paper published with permission.
Draft Genome Sequence and Annotation of the Obligate Bacterial Endosymbiont
Caedibacter taeniospiralis
, Causative Agent of the Killer Phenotype in
Paramecium tetraurelia
Authors: Zaburannyi Nestor , Grosser Katrin , Gasparoni Gilles , Müller Rolf , Schrallhammer Martina , Simon Martin 
Published: January 2018

ABSTRACT

Caedibacter taeniospiralis
is an obligate endosymbiont living in the cytoplasm of
Paramecium tetraurelia
.
C. taeniospiralis
causes the so-called killer trait, eliminating intraspecific competitors of its host when released into the medium by the concerted action of the unusual protein structure R-body (refractile body) in addition to an as-yet-unknown toxin.
Nine Whole-Genome Assemblies of
Yersinia pestis
subsp.
microtus
bv. Altaica Strains Isolated from the Altai Mountain Natural Plague Focus (No. 36) in Russia
Authors: Kislichkina Angelina A. , Bogun Alexandr G. , Kadnikova Lidiya A. , Maiskaya Nadezhda V. , Solomentsev Viktor I. , Dentovskaya Svetlana V. , Balakhonov Sergey V. , Anisimov Andrey P. 
Published: January 2018

ABSTRACT

We report here the draft genome sequences of nine
Yersinia pestis
subsp.
microtus
bv. Altaica strains isolated from the Altai Mountain plague focus (no. 36), which represent the 0.PE4 phylogroup circulating in populations of Mongolian pika (
Ochotona pallasi
).
Draft Genome Sequence of a Novel Bacterium,
Pseudomonas
sp. Strain MR 02, Capable of Pyomelanin Production, Isolated from the Mahananda River at Siliguri, West Bengal, India
Authors: Ranjan Vivek Kumar , Saha Tilak , Mukherjee Shriparna , Chakraborty Ranadhir 
Published: January 2018

ABSTRACT

The draft genome sequence of a novel strain,
Pseudomonas
sp. MR 02, a pyomelanin-producing bacterium isolated from the Mahananda River at Siliguri, West Bengal, India, is reported here. This strain has a genome size of 5.94 Mb, with an overall G+C content of 62.6%. The draft genome reports 5,799 genes (mean gene length, 923 bp), among which 5,503 are protein-coding genes, including the genes required for the catabolism of tyrosine or phenylalanine for the characteristic production of homogentisic acid (HGA). Excess HGA, on excretion, auto-oxidizes and polymerizes to form pyomelanin.
Draft Genome Sequence of
Vibrio parahaemolyticus
Strain M1-1, Which Causes Acute Hepatopancreatic Necrosis Disease in Shrimp in Vietnam
Authors: Kumar Ramya , Chang Che-Chih , Ng Tze Hann , Ding Jiun-Yan , Tseng Ta-Chien , Lo Chu-Fang , Wang Han-Ching 
Published: January 2018

ABSTRACT

We report here the genome sequence of
Vibrio parahaemolyticus
strain M1-1, which causes a mild form of shrimp acute hepatopancreatic necrosis disease (AHPND). Compared to other virulent strains, the M1-1 genome appeared to express several additional genes, while some genes were missing. These instabilities may be related to the reduced virulence of M1-1.
Complete Genome Sequence of
Kyrpidia
sp. Strain EA-1, a Thermophilic Knallgas Bacterium, Isolated from the Azores
Authors: Reiner Johannes Eberhard , Lapp Christian Jonas , Bunk Boyke , Spröer Cathrin , Overmann Jörg , Gescher Johannes 
Published: January 2018

ABSTRACT

Kyrpidia
sp. strain EA-1 is a thermophilic hydrogen-oxidizing bacterium isolated from hydrothermal systems at São Miguel Island, Portugal. Here, we present the complete genome sequence of the strain assembled to a single circular chromosome. The genome spans 3,352,175 bp, with a GC content of 58.7%.
Draft Genome Sequence of a Multistress-Tolerant Yeast,
Pichia kudriavzevii
NG7
Authors: Park Hyun Joo , Ko Hyeok-Jin , Jeong Haeyoung , Lee Sun Hee , Ko Hyun-Jun , Bae Jung-Hoon , Sung Bong Hyun , Han Jong-In , Sohn Jung-Hoon 
Published: January 2018

ABSTRACT

Pichia kudriavzevii
NG7 is a multistress-tolerant yeast, isolated from grape skins. Here, we report the draft genome sequence of
P. kudriavzevii
NG7, to understand its biochemical regulation and metabolic pathways.
Laurentian crust in northeast Australia: Implications for the assembly of the supercontinent Nuna
Authors: Nordsvan Adam R. , Collins William J. , Li Zheng-Xiang , Spencer Christopher J. , Pourteau Amaury , Withnall Ian W. , Betts Peter G. , Volante Silvia 
Published: January 2018

Abstract
The Georgetown Inlier of northeast Australia provides evidence of critical links between Australia and Laurentia during the late Paleoproterozoic and the early Mesoproterozoic. Detrital zircon age spectra from sedimentary strata within the inlier show two distinct changes in sedimentary provenance: (1) the lowermost units (depositional age ca. 1700–1650 Ma) have detrital zircon age spectra that strongly resemble Laurentian magmatic ages and detrital zircon age spectra of the similar-aged Wernecke Supergroup of northwest Laurentia; (2) sediments deposited from ca. 1650 to 1610 Ma show a unimodal proximal signature; and (3) postorogenic sediments deposited after 1550 Ma have detrital zircon age spectra like the Mount Isa Inlier of the North Australia craton. Along with new paleocurrent measurements, the detrital age data challenge current models that suggest that the Georgetown Inlier was part of Australia before ca. 1700 Ma. Rather, we argue it was a continental ribbon rifted from west Laurentia during slab rollback ca. 1680 Ma; by 1650 Ma, the Georgetown Inlier had completely separated from Laurentia, and ca. 1600 Ma collided with Australia during supercontinent Nuna amalgamation.
β-Adrenergic enhancement of neuronal excitability in the lateral amygdala is developmentally gated
Authors: Fink Ann E. , LeDoux Joseph E. 
Published: January 2018

Noradrenergic signaling in the amygdala is important for processing threats and other emotionally salient stimuli, and β-adrenergic receptor activation is known to enhance neuronal spiking in the lateral amygdala (LA) of juvenile animals. Nevertheless, intracellular recordings have not yet been conducted to determine the effect of β-adrenergic receptor activation on spike properties in the adult LA, despite the potential significance of developmental changes between adolescence and adulthood. Here we demonstrate that the β-adrenergic agonist isoproterenol (15 μM) enhances spike frequency in dorsal LA principal neurons of juvenile male C57BL/6 mice and fails to do so in strain- and sex-matched adults. Furthermore, we find that the age-dependent effect of isoproterenol on spike frequency is occluded by the GABAA receptor blocker picrotoxin (75 μM), suggesting that β-adrenergic receptors downregulate tonic inhibition specifically in juvenile animals. These findings indicate a significant shift during adolescence in the cellular mechanisms of β-adrenergic modulation in the amygdala. NEW & NOTEWORTHY β-Adrenergic receptors (β-ARs) in amygdala are important in processing emotionally salient stimuli. Most cellular recordings have examined juvenile animals, while behavioral data are often obtained from adults. We replicate findings showing that β-ARs enhance spiking of principal cells in the lateral amygdala of juveniles, but we fail to find this in adults. These findings have notable scientific and clinical implications regarding the noradrenergic modulation of threat processing, alterations of which underlie fear and anxiety disorders.
Cardiorespiratory Fitness, Coronary Artery Calcium, and Cardiovascular Disease Events in a Cohort of Generally Healthy Middle-Age Men
Authors: Radford Nina B. , DeFina Laura F. , Leonard David , Barlow Carolyn E. , Willis Benjamin L. , Gibbons Larry W. , Gilchrist Susan C. , Khera Amit , Levine Benjamin D. 
Published: January 2018

Background:
A robust literature demonstrates that coronary artery calcification (CAC) and cardiorespiratory fitness (CRF) are independent predictors of cardiovascular disease (CVD) events. Much less is known about the joint associations of CRF and CAC with CVD risk. In the setting of high CAC, high versus low CRF has been associated with decreased CVD events. The goal of this study was to assess the effect of continuous levels of CRF on CVD risk in the setting of increasing CAC burden.

Methods:
We studied 8425 men without clinical CVD who underwent preventive medicine examinations that included an objective measurement of CRF and CAC between 1998 and 2007. There were 383 CVD events during an average follow-up of 8.4 years. Parametric proportional hazards regression models based on a Gompertz mortality rule were used to estimate total CVD incidence rates at 70 years of age as well as hazard ratios for the included covariates.

Results:
CVD events increased with increasing CAC and decreased with increasing CRF. Adjusting for CAC level (scores of 0, 1–99, 100–399, and ≥400), for each additional MET of fitness, there was an 11% lower risk for CVD events (hazard ratio, 0.89; 95% confidence interval, 0.84-0.94). When CAC and CRF were considered together, there was a strong association between continuous CRF and CVD incidence rates in all CAC groups.

Conclusions:
In a large cohort of generally healthy men, there is an attenuation of CVD risk at all CAC levels with higher CRF.
Short-Term Solar Modulation of the Madden–Julian Climate Oscillation
Authors: Hood Lon L. 
Published: January 2018

Abstract
Normalized occurrence rates of daily Madden–Julian oscillation (MJO) events are calculated as a function of phase lag relative to peaks and minima in solar ultraviolet flux occurring on the solar rotational time scale (~27 days). All MJO phases and four solar maximum periods are considered (1979–83, 1989–93, 1999–2003, and 2011–15). Corresponding daily static stabilities in the tropical lower stratosphere (70–100 hPa) are calculated from ERA-Interim data and are averaged over the warm pool region. The statistical significance of occurrence-rate changes following UV peaks and minima is assessed using a Monte Carlo method. When MJO events with amplitudes greater than about 2 are considered during the December–May period (about 15% of those days), significant reductions of MJO occurrence rates and associated increases in static stability in the tropical lower stratosphere are obtained 1–7 days following solar UV peaks. Consistently, cross-correlation analyses of high-pass-filtered daily MJO amplitudes and solar UV flux during the same seasonal period produce significant negative correlations near and following solar UV peaks. Conversely, mean occurrence rates are increased and lower-stratospheric static stabilities are decreased following solar UV minima. The reductions (increases) in occurrence rate following solar UV peaks (minima) are largest when the stratospheric quasi-biennial oscillation is in its easterly phase. Little or no dependence of the solar modulation on the phase of El Niño–Southern Oscillation is obtained.
Associations of the lipid genetic variants Thr54 (FABP2) and -493T (MTTP) with total cholesterol and low-density lipoprotein cholesterol levels in Mexican subjects
Authors: Gonzalez-Becerra Karina , Ramos-Lopez Omar , Garcia-Cazarin Mary Lolis , Barron-Cabrera Elisa , Panduro Arturo , Martinez-Lopez Erika 
Published: January 2018

Objective Mexico has one of the world’s highest rates of obesity, which is influenced by lipid-genetic and lifestyle factors. This study aimed to determine whether FABP2 (Ala54Thr) and MTTP (-493 G/T) genetic polymorphisms are associated with metabolic disorders in Mexican subjects. Methods A total of 523 subjects participated in a cross-sectional study. Genotyping for FABP2 and MTTP was performed using real-time RT-PCR. Biochemical and anthropometric data were evaluated. Results The genetically at-risk group (Thr54/-493T) was associated with significantly higher total and low-density lipoprotein cholesterol levels (difference between genetically at-risk group and wild-type group: 10.6 mg/dL and 8.94 mg/dL, respectively). Carriers within the genetically at-risk group had a significantly higher prevalence rate of hypercholesterolaemia (42.5% vs. 32.0%) and higher LDL-C levels (37.6% vs. 26.4%) than did non-carriers. Conclusions Subjects who are genetically at risk (Thr54/-493T) have higher total cholesterol levels, low-density lipoprotein cholesterol levels, and prevalence rate of hypercholesterolaemia. These findings highlight the importance of basing nutritional intervention strategies for preventing and treating chronic diseases on individual genetic characteristics.
“Mer hjelp, mindre moralpreken”
Authors: Jørstad Marie Lindvik , Skogheim Thea Steen , Bergsund Hans Bugge 
Published: January 2018

Background: Anabolic-androgenic steroid (AAS) use can lead to increased muscle mass and strength as well as undesired side effects with varying severities. In Norway, the specialized health services responsible for treating substance use disorders are also responsible for help provision to AAS users with health problems. The aim of this study was to find out how health services can be made more accessible to AAS users in need of treatment. Methods: A questionnaire was posted on four online forums, and explored the following themes: use of AAS, side effects, need for health services, and interest in health services. Results: Seventy-four respondents answered the questionnaire, of which 57 were current AAS users and 17 were previous users. Only one of the previous users had received treatment after ceasing use of AAS; the majority ceased use without external assistance. To facilitate uptake of health services, respondents identified assurance of confidentiality, treatment provider expertise of AAS, and respect during treatment as important factors. Most respondents expressed interest in a no-obligation health assessment. Conclusion: Increased knowledge of AAS among health services providers may help counteract stigma, build up users’ trust in help provision, and reach those who want health services without disclosing their AAS use. AAS users should be made aware of providers’ confidentiality obligations and the fact that treatment will not lead to punishment. Treatment offers which include easy access to a no-obligation health assessment and information about treatment options may be key to reaching AAS users in need.
Proximal to Distal Exostectomy for the Treatment of Insertional Achilles Tendinopathy
Authors: McBeth Zachary L. , Galvin Joseph W. , Robbins Justin 
Published: January 2018

When insertional Achilles tendinopathy is addressed surgically via a central-Achilles splitting approach, the calcaneal osteotomy has classically been performed from distal to proximal. We describe a simple proximal to distal technique that allows optimal resection of both the calcaneal exostosis and Achilles enthesophyte, minimizes risk to the soft tissues and skin, provides a bony attachment surface parallel to the axis of the Achilles tendon, and avoids the risk of osteotomy extension into the subtalar joint. Levels of Evidence: Level V: Technique tip
Diagnosis and treatment of latent tuberculosis in patients with multiple sclerosis, expert consensus. On behalf of the Colombian Association of Neurology, Committee of Multiple Sclerosis
Authors: Navas Carlos , Torres-Duque Carlos A , Munoz-Ceron Joe , Álvarez Carlos , García Juan R , Zarco Luis , Vélez Lázaro A , Awad Carlos , Castro Carlos Alberto 
Published: January 2018

Background Multiple sclerosis is an inflammatory and neurodegenerative demyelinating disease. Current treatment of multiple sclerosis focuses on the use of immunomodulatory, immunosuppressant, and selective immunosuppressant agents. Some of these medications may result in high risk of opportunistic infections including tuberculosis. Objective The purpose of this study was to obtain consensus from a panel of neurologists, pulmonologists, infectious disease specialists, and epidemiology experts regarding the diagnosis, treatment, and monitoring of latent tuberculosis in patients with multiple sclerosis. Methods A panel of experts in multiple sclerosis and tuberculosis was established. The methodological process was performed in three phases: definition of questions, answer using Delphi methodology, and the discussion of questions not agreed. Results Tuberculosis screening is suggested when multiple sclerosis drugs are prescribed. The recommended tests for latent tuberculosis are tuberculin and interferon gamma release test. When an anti-tuberculosis treatment is indicated, monitoring should be performed to determine liver enzyme values with consideration of age as well as comorbid conditions such as a history of alcoholism, age, obesity, concomitant hepatotoxic drugs, and history of liver disease. Conclusion Latent tuberculosis should be considered in patients with multiple sclerosis who are going to be treated with immunomodulatory and immunosuppressant medications. Transaminase level monitoring is required on a periodic basis depending on clinical and laboratory characteristics. In addition to the liver impairment, other side effects should be considered when Isoniazid is prescribed.
NR4A1 and NR4A3 restrict HSC proliferation via reciprocal regulation of C/EBPα and inflammatory signaling
Authors: Freire Pablo R. , Conneely Orla M. 
Published: January 2018

Key Points
NR4A1/3 nuclear receptors suppress hyperproliferation and DNA damage of HSCs. NR4A1/3 act as transcriptional activators of C/EBPα while repressing a proliferative inflammatory response in HSCs.
Novel Pilot Curriculum for International Education of Lymphoma Management Using E-Contouring
Authors: Mailhot Vega Raymond B. , Ishaq Omar F. , Ahmed Inaya , Rene Luis , Amendola Beatriz E. , Hu Kenneth S. 
Published: January 2018

Purpose The International Lymphoma Radiation Oncology Group (ILROG) published consensus guidelines on the management of Hodgkin disease (HD) and nodal non-Hodgkin lymphoma (NHL), which became the most downloaded articles from International Journal of Radiation Oncology, Biology, and Physics. E-contouring workshops allow for interactive didactic sessions, allowing participants to see case-based contouring in real time. A pilot 1-hour curriculum was developed with the objective of reviewing ILROG guidelines for HD and NHL management with incorporation of e-contouring tools. This represents the first international education intervention in Spanish using e-contouring with a pre- and postintervention questionnaire. Methods A 1-hour presentation was prepared in Spanish reviewing the ILROG recommendations for HD and NHL. The review was followed by the author’s demonstration of contour creation using patients with HD and NHL prepared for the American Society for Radiation Oncology’s 2015 e-contouring lymphoma session. A five- question evaluation was prepared and administered before and after intervention. A two-tailed paired t test was performed to evaluate any significant change in test value before and after intervention. Results A total of nine quizzes were collected before and after the intervention. The average test score before the intervention was 75.6%, and the average test score after the intervention was 86.7% ( P = .051). Four students scored 100% on both the pre- and postintervention evaluations, and no student had a decrease in score from pre- to postintervention evaluation. The topic with the lowest score tested dose consideration. Conclusion A substantial but nonsignificant improvement in test evaluation was seen with this pilot curriculum. This pilot intervention identified obstacles for truly interactive didactic sessions that, when addressed, can lead to fully developed interactive didactic sessions.
Dimension-Controlled π-Electronic Ion-Pairing Assemblies
Authors: Haketa Yohei , Maeda Hiromitsu 
Published: January 2018

Abstract
Ion-pairing assemblies consisting of appropriately designed π-electronic ionic species afford various functional supramolecular assemblies including crystals and soft materials based on the anisotropic orientation of π-electronic ionic species through electrostatic and other weak noncovalent interactions. Organized assemblies comprising π-electronic ionic species as dimension-controlled assemblies provide unique and tunable mesophases and electronic properties. As components of dimension-controlled ion-pairing assemblies, π-electronic ion pairs are important and have been prepared through (i) synthesis of π-electronic units bearing ionic substituents, (ii) synthesis of genuine π-electronic ions, and (iii) complexation of π-electronic receptors and ions. In (ii) and (iii), appropriate ion-exchange processes are necessary. Based on these strategies, fascinating ion pairs and their assemblies have been constructed, resulting in an elucidation of the assembling behaviors of π-electronic ion pairs. In this article, ion-pairing assemblies consisting of precisely designed π-electronic ionic species are described, with a focus on the preparation methods, structures, and properties.
The Organizing of FIS Nordic Ski World Championships Lahti 2017 in the Context of ISO 20121:2012 Standard
Authors: Białkowski Cezary 
Published: January 2018

StreszczenieW dzisiejszych czasach zarządzanie wykracza poza klasyczne formy działalności gospodarczej. Standard ISO 20121:2012 koresponduje z tym motywem i stanowi normę zarządzania środowiskowego przeznaczoną dla organizacji imprez. Celem artykułu jest porównanie metod służących przeprowadzeniu Mistrzostw Świata w Narciarstwie Klasycznym Lahti 2017 z modelem proponowanym przez Międzynarodową Organizację Standaryzacji. W wyniku badań opartych na publikowanych przez komitet organizacyjny dokumentach (materiale źródłowym) można stwierdzić, że przeprowadzona na przełomie lutego i marca 2017 roku impreza, pomimo drobnych różnic w przedstawionym programie zrównoważonego rozwoju, wpisywała się swoimi działaniami w standardowe sposoby organizacji imprez wykorzystujących ISO 20121:2012. AbstractNowadays, management outreaches basic standards of an economics activity. In this context, the ISO 20121:2012 standard is a norm of environmental management. The main aim of this paper is comparison methods of FIS Nordic Ski World Championships Lahti 2017 preparing with the International Standardization Organization model. By the research, which was based on published documents (source material), it can say, that February – March 2017 event was organized by ISO 20121:2012 rules (also sustainable development policy), although it can see some minor differents.