bluuebunny/crossref_metadata_2025_split huggingface dataset:
GROWING UP IN PORTUGAL: CAPE VERDEAN ANCESTRY CHILDREN EXHIBIT LOW OVERWEIGHT AND OBESITY COMPARED WITH PORTUGUESE IN URBAN LISBON
Authors: André A. L. , Padez C. , Rosado-Marques V. , Griffiths P. L. , Varela-Silva M. I. 
Published: December 2016

SummaryPortugal has one of the highest rates of childhood overweight and obesity in Europe. However, little is known about the health of ethnic minorities living in its capital city, Lisbon. The Cape Verdean community in Lisbon tend to have low educational levels, material deprivation and struggle with discrimination and racism, factors that would probably be associated with a higher prevalence of overweight and obesity. Data for the Cape Verdean population were collected in three different time periods by three different research teams in 1993, 2009 and 2013 and included children aged 6–12 years living in the Cova da Moura neighbourhood of the Greater Lisbon Metro Area. The Portuguese national survey was conducted between 2009 and 2010 at public and private schools in mainland Portugal and included height, weight, skinfolds and arm and waist circumferences. From these survey data body mass index (BMI) and prevalence of stunting (chronic malnutrition – low height-for-age) and underweight (low weight-for-age) were calculated according to reference values proposed by Frisancho (2008). Overweight and obesity prevalence values were defined based on the references established by the International Obesity Task Force. The results show significant differences in height between Cape Verdean and Portuguese boys and girls. Generally, Cape Verdeans’ growth falls within the healthy range of international growth references across all of the survey data collected. Cape Verdean rates for combined overnutrition (overweight and obesity) in 2013 (9.8% for boys and 16.7% for girls) were lower than those of the Portuguese (33% for boys and 31.7% for girls). Logistic regression models showed that Cape Verdean children had a lower risk of being overweight or obese when accounting for breast-feeding, birth weight, maternal education and occupation. Despite living in a deprived neighbourhood these Cape Verdean children seemed to have grown more healthily than Portuguese ancestry children. The challenge for policymakers will be to support improvement of the poverty-related living conditions of this community without creating a risky environment for increasing prevalence of overweight and obesity.
Platelet-rich plasma in otolaryngology
Authors: Stavrakas M , Karkos P D , Markou K , Grigoriadis N 
Published: December 2016

AbstractBackground:Platelet-rich plasma is a novel material that is being used more frequently in many surgical specialties.Methods:A literature review on the current and potential uses of platelet-rich plasma in otolaryngology was performed.Results:There is limited evidence on the use of platelet-rich plasma in otolaryngology compared with other specialties: only 11 studies on various subspecialties (otology, rhinology and laryngology) were included in the final review.Conclusion:Based on the limited number of studies, we cannot draw safe conclusions about the value of platelet-rich plasma in otolaryngology. Nevertheless, the available literature suggests that platelet-rich plasma holds promise for future research and may have a number of clinical applications.
Genetic polymorphism and population structure ofEchinococcus ortleppi
Authors: ADDY F. , WASSERMANN M. , BANDA F. , MBAYA H. , ASCHENBORN J. , ASCHENBORN O. , KOSKEI P. , UMHANG G. , DE LA RUE M. , ELMAHDI I. E. , MACKENSTEDT U. , KERN P. , ROMIG T. 
Published: December 2016

SUMMARYThe zoonotic cestodeEchinococcus ortleppi(Lopez-Neyra and Soler Planas, 1943) is mainly transmitted between dogs and cattle. It occurs worldwide but is only found sporadically in most regions, with the notable exception of parts of southern Africa and South America. Its epidemiology is little understood and the extent of intraspecific variability is unknown. We have analysed in the present study the genetic diversity among 178E. ortleppiisolates from sub-Saharan Africa, Europe and South America using the complete mitochondrialcox1(1608 bp) andnad1(894 bp) DNA sequences. Genetic polymorphism within the loci revealed 15cox1and sixnad1haplotypes, respectively, and 20 haplotypes of the concatenated genes. Presence of most haplotypes was correlated to geographical regions, and only one haplotype had a wider spread in both eastern and southern Africa. Intraspecific microvariance was low in comparison withEchinococcus granulosussensu stricto, despite the wide geographic range of examined isolates. In addition, the various sub-populations showed only subtle deviation from neutrality and were mostly genetically differentiated. This is the first insight into the population genetics of the enigmatic cattle adaptedEchinococcus ortleppi. It, therefore, provides baseline data for biogeographical comparison amongE. ortleppiendemic regions and for tracing its translocation paths.
Plasmodium knowlesi: a relevant, versatile experimental malaria model
Authors: PASINI ERICA M. , ZEEMAN ANNE-MARIE , VOORBERG-VAN DER WEL ANNEMARIE , KOCKEN CLEMENS H. M. 
Published: December 2016

SUMMARYThe primate malariaPlasmodium knowlesihas a long-standing history as an experimental malaria model. Studies using this model parasite in combination with its various natural and experimental non-human primate hosts have led to important advances in vaccine development and in our understanding of malaria invasion, immunology and parasite–host interactions. The adaptation to long-termin vitrocontinuous blood stage culture in rhesus monkey,Macaca fascicularisand human red blood cells, as well as the development of various transfection methodologies has resulted in a highly versatile experimental malaria model, further increasing the potential of what was already a very powerful model. The growing evidence thatP. knowlesiis an important human zoonosis in South-East Asia has added relevance to former and future studies of this parasite species.
The antileishmanial activity of xanthohumol is mediated by mitochondrial inhibition
Authors: MONZOTE LIANET , LACKOVA ALEXANDRA , STANIEK KATRIN , STEINBAUER SILVIA , PICHLER GERALD , JÄGER WALTER , GILLE LARS 
Published: December 2016

SUMMARYXanthohumol (Xan) is a natural constituent of human nutrition. Little is known about its actions on leishmanial parasites and their mitochondria as putative target. Therefore, we determined the antileishmanial activity of Xan and resveratrol (Res, as alternative compound with antileishmanial activity) with respect to mitochondria inLeishmania amazonensispromastigotes/amastigotes (LaP/LaA) in comparison with their activity in peritoneal macrophages from mouse (PMM) and macrophage cell line J774A.1 (J774). Mechanistic studies were conducted inLeishmania tarentolaepromastigotes (LtP) and mitochondrial fractions isolated from LtP. Xan and Res demonstrated antileishmanial activity in LaA [half inhibitory concentration (IC50): Xan 7µm, Res 14µm]; while they had less influence on the viability of PMM (IC50: Xan 70µm, Res >438µm). In contrast to Res, Xan strongly inhibited oxygen consumption inLeishmania(LtP) but not in J774 cells. This was based on the inhibition of the mitochondrial electron transfer complex II/III by Xan, which was less pronounced with Res. Neither Xan nor Res increased mitochondrial superoxide release in LtP, while both decreased the mitochondrial membrane potential in LtP. Bioenergetic studies showed that LtP mitochondria have no spare respiratory capacity in contrast to mitochondria in J774 cells and can therefore much less adapt to stress by mitochondrial inhibitors, such as Xan. These data show that Xan may have antileishmanial activity, which is mediated by mitochondrial inhibition.
Hypogyrification in obsessive-compulsive disorder
Authors: Rus O. G. , Reess T. J. , Wagner G. , Zaudig M. , Zimmer C. , Koch K. 
Published: December 2016

BackgroundPrevious studies hypothesized that neurodevelopmental risk factors may play a role in the pathogenesis of obsessive-compulsive disorder (OCD). Cortical folding has been shown to be a reliable indicator for normal and altered neurodevelopment, but in OCD it has barely been investigated up to now. The present study investigates whether alterations in gyrification are detectable in OCD and, if so, how these are associated with clinical characteristics.MethodWe compared the local Gyrification Index (lGI) between 75 OCD patients and 75 matched healthy subjects across the whole brain. In addition, for those regions exhibiting an altered lGI in patients we explored a potential relationship to symptom severity, age of onset, and influence of medication.ResultsOCD patients had a significantly decreased lGI in right parietal, precentral but also insula, temporal, pars triangularis and rostral middle frontal regions compared to healthy subjects. A positive association with age of onset was found but no association with symptom severity. There was no effect of co-morbidity or medication.ConclusionsThe reduced gyrification found in OCD confirms previous findings in other psychiatric disorders and suggests that alterations may already occur during early stages of brain development. Our findings support the idea that altered cortical folding might represent a trait characteristic of the disorder although longitudinal studies are needed to clarify the trajectory of this morphological measure in OCD.
Aixone: insights into an Athenian deme
Authors: Papadopoulou Chryssanthi 
Published: December 2016

The ancient deme of Aixone coincides with the area of the modern Athenian suburb of Glyphada. An extensive, comprehensive study on this deme was published in 1990 by Eleni Konsolaki-Giannopoulou. Since then, new excavation data have come to light which support the conclusions of this study and provide us with even greater insights into the life of the deme. Another monograph on Aixone will be published by Delphine Ackermann in 2017, entitled Une microhistoire d’Athènes. Le dème d’Aixônè dans l’Antiquité.Aixone, along with neighbouring Halai Aixonidai, belonged to the Kekropis tribe. In Classical and Hellenistic times the settlement extended from the west of Pirnari to the east of modern Leoforos Dimarchou Aggelou Metaxa, thus coinciding for the large part with the area of modern Glyphada. The deme centre lay near the Church of Agios Nikolaos, west of modern Vouliagmenis Avenue (Eliot 1962: 21). To the east of the settlement lay the deme's agricultural lands and to the west the port, salt lake and the salt pits.
The campylobacteriosis conundrum – examining the incidence of infection withCampylobactersp. in Australia, 1998–2013
Authors: MOFFATT C. R. M. , GLASS K. , STAFFORD R. , D'ESTE C. , KIRK M. D. 
Published: December 2016

SUMMARYCampylobactersp. are a globally significant cause of gastroenteritis. Although rates of infection in Australia are among the highest in the industrialized world, studies describing campylobacteriosis incidence in Australia are lacking. Using national disease notification data between 1998 and 2013 we examinedCampylobacterinfections by gender, age group, season and state and territory. Negative binomial regression was used to estimate incidence rate ratios (IRRs), including trends by age group over time, with post-estimation commands used to obtain adjusted incidence rates. The incidence rate for males was significantly higher than for females [IRR 1·20, 95% confidence interval (CI) 1·18–1·21], while a distinct seasonality was demonstrated with higher rates in both spring (IRR 1·18, 95% CI 1·16–1·20) and summer (IRR 1·17, 95% CI 1·16–1·19). Examination of trends in age-specific incidence over time showed declines in incidence in those aged <40 years combined with contemporaneous increases in older age groups, notably those aged 70–79 years (IRR 1998–2013: 1·75, 95% CI 1·63–1·88). While crude rates continue to be highest in children, our findings suggest the age structure for campylobacteriosis in Australia is changing, carrying significant public health implications for older Australians.
Programming with ornaments
Authors: KO HSIANG-SHANG , GIBBONS JEREMY 
Published: December 2016

AbstractDependently typed programming advocates the use of various indexed versions of the same shape of data, but the formal relationship amongst these structurally similar datatypes usually needs to be established manually and tediously. Ornaments have been proposed as a formal mechanism to manage the relationships between such datatype variants. In this paper, we conduct a case study under an ornament framework; the case study concerns programming binomial heaps and their operations — including insertion and minimum extraction — by viewing them as lifted versions of binary numbers and numeric operations. We show how current dependently typed programming technology can lead to a clean treatment of the binomial heap constraints when implementing heap operations. We also identify some gaps between the current technology and an ideal dependently typed programming language that we would wish to have for our development.
Alcohol use, depression, and life satisfaction among older persons in Jamaica
Authors: Gibson Roger C. , Waldron Norman K. , Abel Wendel D. , Eldemire-Shearer Denise , James Kenneth , Mitchell-Fearon Kathryn 
Published: December 2016

ABSTRACTBackground:We aimed to determine the prevalence of alcohol use among older Jamaicans as well as to explore among this population the relationships between alcohol use and: age, sex, depressive symptoms, and life satisfaction. Although the nature of these relationships among the proposed study population were uncertain, in other settings alcohol use has tended to decline with increasing age, occur more commonly among men than women, and show non-linear relationships with depressive symptoms and life satisfaction.Methods:Data gathered by two-stage cluster sampling for a nationally representative health and lifestyle survey of 2,943 community-dwelling older Jamaicans, aged 60 to 103 years, were subjected to secondary analysis using the Student's t-test and χ2 test as appropriate.Results:Current alcohol use was reported by 21.4% of the participants. It steadily declined with age and was six times more prevalent among men (37.6%) than women (6.2%). These findings were statistically significant as were associations of current alcohol use with comparatively lower levels of depressive symptoms. Current alcohol use was also more prevalent among persons who were either highly satisfied or highly dissatisfied with their lives, compared to others who had levels of life satisfaction between these two extremes.Conclusions:Current alcohol use among older Jamaicans occurs primarily among men, declines with increasing age, and is associated with a relatively low likelihood of depression. It is also associated with very high and very low levels of life satisfaction.
Cardiac manifestations of congenital LMNA-related muscular dystrophy in children: three case reports and recommendations for care
Authors: Heller Felice , Dabaj Ivana , Mah Jean K. , Bergounioux Jean , Essid Aben , Bönnemann Carsten G. , Rutkowski Anne , Bonne Gisèle , Quijano-Roy Susana , Wahbi Karim 
Published: December 2016

AbstractSkeletal and cardiac muscle laminopathies, caused by mutations in the lamin A/C gene, have a clinical spectrum from congenital LMNA-related muscular dystrophy to later-onset Emery–Dreifuss muscular dystrophy, limb girdle muscular dystrophy, and dilated cardiomyopathy. Although cardiac involvement is observed at all ages, it has only been well described in adults. We present the evolution of cardiac disease in three children with congenital muscular dystrophy presentation of LMNA-related muscular dystrophy. In this series, atrial arrhythmia was the presenting cardiac finding in all three patients. Heart failure developed up to 5 years later. Symptoms of right heart failure, including diarrhoea and peripheral oedema, preceded a rapid decline in left ventricular ejection fraction. Recommendations for cardiac surveillance and management in these patients are made.
Role of low kilovoltage electrocardiographic-gated multidetector CT in electrophysiological procedures in the paediatric age group
Authors: Khalil Sameh N. K. , Ibrahim Ahmed S. 
Published: December 2016

AbstractTreatment of arrhythmias by catheter ablation targeting the anatomical foci of arrhythmias by radiofrequency has evolved dramatically in recent years. A road map for the relevant heart structures is an important asset for the success of the procedure and should be obtained before the intervention. This can be achieved by intra-cardiac echocardiography, conventional angiographic methods, multidetector CT, or MRI. The electrophysiological technique comprises a diagnostic procedure and an interventional – therapeutic – procedure. Electrocardiographic-gated multidetector CT is important in the diagnostic session to evaluate the anatomical details in combination with electric activity mapping. This combined protocol provides a unique view of the propagation of electrical activity, either normal or abnormal, over cardiac structures and allows a precise functional and anatomical evaluation to be obtained. In this review, we evaluate the role of electrocardiographic-gated multidetector CT in roadmapping arrhythmias in the paediatric age group, focussing on its strengths; we also evaluated some additional aspects that need further improvement in the future.
Health Service Impact from Mass Gatherings: A Systematic Literature Review
Authors: Ranse Jamie , Hutton Alison , Keene Toby , Lenson Shane , Luther Matt , Bost Nerolie , Johnston Amy N. B. , Crilly Julia , Cannon Matt , Jones Nicole , Hayes Courtney , Burke Brandon 
Published: December 2016

AbstractBackgroundDuring a mass gathering, some participants may receive health care for injuries or illnesses that occur during the event. In-event first responders provide initial assessment and management at the event. However, when further definitive care is required, municipal ambulance services provide additional assessment, treatment, and transport of participants to acute care settings, such as hospitals. The impact on both ambulance services and hospitals from mass-gathering events is the focus of this literature review.AimThis literature review aimed to develop an understanding of the impact of mass gatherings on local health services, specifically pertaining to in-event and external health services.MethodThis research used a systematic literature review methodology. Electronic databases were searched to find articles related to the aim of the review. Articles focused on mass-gathering health, provision of in-event health services, ambulance service transportation, and hospital utilization.ResultsTwenty-four studies were identified for inclusion in this review. These studies were all case-study-based and retrospective in design. The majority of studies (n=23) provided details of in-event first responder services. There was variation noted in reporting of the number and type of in-event health professional services at mass gatherings. All articles reported that patients were transported to hospital by the ambulance service. Only nine articles reported on patients presenting to hospital. However, details pertaining to the impact on ambulance and hospital services were not reported.ConclusionsThere is minimal research focusing on the impact of mass gatherings on in-event and external health services, such as ambulance services and hospitals. A recommendation for future mass-gathering research and evaluation is to link patient-level data from in-event mass gatherings to external health services. This type of study design would provide information regarding the impact on health services from a mass gathering to more accurately inform future health planning for mass gatherings across the health care continuum.RanseJ, HuttonA, KeeneT, LensonS, LutherM, BostN, JohnstonANB, CrillyJ, CannonM, JonesN, HayesC, BurkeB. Health service impact from mass gatherings: a systematic literature review. Prehosp Disaster Med. 2017;32(1):71–77.
Effect of fortified milk on growth and nutritional status in young children: a systematic review and meta-analysis
Authors: Matsuyama Misa , Harb Tracy , David Michael , Davies Peter SW , Hill Rebecca J 
Published: December 2016

AbstractObjectiveAdequate nutrition is critical for optimal growth and development. However, young children may be at risk of nutrient deficiencies when transitioning to weaning foods for a variety of reasons. Supplementation with fortified milk may provide potentially lacking essential nutrients, but effects on growth and nutritional status are yet to be established.DesignFive databases were searched for randomised controlled trials using fortified milk against control milk in young children. Outcomes were growth, body composition and/or biochemical markers. Pooled differences in means were calculated for continuous outcomes and odds ratios for binary outcomes.SettingRandomised controlled trials set in any country.SubjectsOtherwise healthy children aged 6–47 months.ResultsFifteen articles met the eligibility criteria. Fortification varied from Fe, Zn, vitamins, essential fatty acids, to pre- and/or probiotics. Frequently reported outcomes were weight, height and Fe status. Studies varied in geographical location, sample size and duration. Fortified milk had minimal effects on weight gain (mean difference=0·17 kg; 95 % CI 0·02, 0·31 kg) compared with control milk. The risk of anaemia was reduced in fortified milk groups (OR=0·32; 95 % CI 0·15, 0·66) compared with control groups. There were no significant effects on height gain, changes in body composition or Hb concentration.ConclusionsFortified milk is an effective source of complementary nutrition to supplement children in need when consumed in appropriate amounts in addition to a normal diet. Due to compositional differences, further research on fortified milk is warranted before making global recommendations on benefits for growth and nutritional outcomes in young children.
Imaging of Dental Hard Tissue Surfaces Prepared by an Ultrashort Pulsed Laser System (USPL)
Authors: Schäper Matthias , Reimann Susanne , Frentzen Matthias , Meister Jörg 
Published: December 2016

AbstractThe aim of this study was to compare surface structures of laser-irradiated dental hard tissues using confocal (CFM), atomic force (AFM), and scanning electron microscopy (SEM). The general potential of the AFM in analyzing laser-irradiated surfaces was determined in this context. Specimens of human enamel and dentin were irradiated using an 8.6 W Nd:YVO4laser with a pulse duration of 8 ps,λCenter=1,064 nm, and a pulse repetition rate of 500 kHz. Surface topology of irradiated areas (1 mm2) was investigated using AFM, CFM, and SEM. Surface roughnessRzwas measured only with the AFM and the CFM. For non-irradiated enamel and dentin surfaces, roughnesses for CFM and AFM are in the nanometer range. However, major differences in roughness were determined for laser-prepared surfaces. For enamel,Rz(CFM)=2.33μm is much higher compared withRz(AFM)=0.09μm; in the case of dentin,Rz(CFM)=5.35μm is also much higher compared withRz(AFM)=0.093μm. Information regarding structural properties of surfaces needs real dimensions, particularly for use in dentistry. In this respect, AFM technology provides no additional results that lead to a significant improvement.