bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of RNA Polymerase Inhibitors as Therapeutics for Tuberculous Meningitis
Authors: Vummidi Varalakshmi , Talluri Sekhar 
Published: September 2024

Background:
Tuberculosis is an infectious disease caused by Mycobacterium tuber-culosis. The current treatment protocols for pulmonary tuberculosis are quite effective, even though the treatment requires 3-6 months. The current treatment protocols for extrapulmonary tuberculosis are based on the same drugs that are used for pulmonary tuberculosis. However, the success rates are much lower for certain types of extrapulmonary tuberculosis, such as tubercu-lous meningitis. Tuberculous meningitis is one of the very few diseases attributable to bacteria that have a very high short-term mortality rate among diagnosed patients, even after treatment with antibiotics that are effective for pulmonary tuberculosis. For example, rifampicin is highly effective for the treatment of pulmonary tuberculosis, but its effectiveness for the treatment of tuberculous meningitis is much lower. The reason for the lower effectiveness of rifampicin against tuberculous meningitis is that it has low Blood-Brain Barrier (BBB) permeability, which results in lower concentrations of the drug at the required sites in the central nervous system.

Methods:
In this work, ligands having increased BBB permeability and pharmacokinetic and pharmacodynamic properties, either similar to or better than that of rifampicin, have been de-signed. The BBB permeability of the designed molecules was assessed by using pkCSM, a ma-chine-learning model. Pharmacokinetic properties, drug-likeness, and synthesizability were as-sessed by using SWISS-MODEL. The binding affinity of the designed drugs was assessed by using AutoDock Vina. A customized scoring function, StWN score, was used for a quantitative weighted assessment of all the properties of interest to rank the designed molecules.

Results:
In this study, drug-like ligands have been designed that have been predicted to have high BBB permeability as well as high affinity for RNA polymerase  ofMycobacterium tuberculosis.

Conclusion:
The best ligands generated by the tools employed were selected as potential drugs to address the current need for better options for the treatment of tuberculous meningitis.
An Analysis of the Radiosensitiser Applications in the Biomedical Field
Authors: Lim Teng Sheng , Abdul Rahman Irman , Umar Aminah , Mohd Hidzir Norsyahidah , Paul Arkill Kenton , Sharif Razinah , Jonet Mohd Anuar , Munawar Kabir Mohd Hur , Mohamed Faizal 
Published: September 2024

Background:
Various types of radiosensitisers have been introduced from the past until
the present day for applications in the biomedical field. However, there is a lack of understanding
and comparison between the various parameters introduced in addition to a lack of consensus
among researchers on the optimal radiosensitiser for applications in the biomedical field.

Objective:
This review aimed to investigate the usage of radiosensitisers in the biomedical field,
determine their important parameters, and suggest radiosensitisers with potential among the analysed
radiosensitisers.

Results and Conclusion:
This review has discussed several parameters for radiosensitisers, including
median lethal dose, cell survival, tumour size, cell viability, Dose Enhancement Factor
(DEF), Reactive Oxygen Species (ROS) concentration, radiosensitiser production complexity, radiosensitiser
administration technique, and radiosensitiser toxicity. General trends regarding the
development of radiosensitisers, including the types, effectiveness, and their production complexity,
have also been discussed within this review article.
Epidemiological Characteristics and Spatiotemporal Analysis of Occupational Noise–Induced Deafness From 2006 to 2022 in Guangdong, China: Surveillance Study
Authors: Zhou Shanyu , Huang Yongshun , Chen Lin , Wen Xianzhong , Wang Shu , Huang Lang , Li Xudong 
Published: September 2024

Abstract

Background
Occupational noise–induced deafness (ONID) has replaced occupational poisoning as the second most common occupational disease in China since 2015. However, there is a limited number of articles on epidemiological characteristics of legally diagnosed ONID.

Objective
We conducted a comprehensive analysis of the epidemiological and spatiotemporal characteristics of ONID in Guangdong Province from 2006 to 2022, with the aim of providing a scientific foundation for policy formulation and health resource allocation.

Methods
Surveillance data of ONID cases in Guangdong Province from 2006 to 2022 were obtained from the “Occupational Diseases and Health Hazard Factors Monitoring Information System.” Joinpoint regression analysis was applied to assess the long-term trends in cases of ONID from 2006 to 2022. Global spatial autocorrelation analysis was performed to measure the overall degree of similarity of the attribute values of spatially adjacent or neighboring regional units. The local indicators of spatial autocorrelation (LISA) plots were then used to identify the local clusters of ONID in Guangdong.

Results
There were 3761 ONID cases in Guangdong Province from 2006 to 2022, showing a significantly increased trend in cases across the entire study period (average annual percentage change 21.9, 95% CI 18.7-35.1). The Moran’s I values for the period of 2006 to 2022 ranged from 0.202 to 0.649 (all P<.001), indicating a positive spatial correlation of ONID across regions each year in Guangdong Province. A total of 15 high-high clusters were notably concentrated in specific counties within the Pearl River Delta.

Conclusions
Significant spatiotemporal patterns of ONID in Guangdong Province from 2006 to 2022 were identified, characterized by a dramatic increase followed by stabilization in case numbers. ONID predominantly occur in manufacturing industries, domestically funded enterprises, among males, individuals aged 40‐49 years, and those with 5+ years of occupational noise exposure. Spatial analysis demonstrated significant clustering in the Pearl River Delta region, with consistent positive spatial autocorrelation across years. These results could help prioritize the allocation of resources for targeted prevention and control measures for ONID.
Identification and Antimicrobial Susceptibility of Serovar Choleraesuis in a Salmonella Outbreak in Central-Western Albania
Authors: Lufo Liljana , Dura Gjena , Çuko Andon , Turmalaj Luigj 
Published: September 2024

Abstract
Swine paratyphoid infection is caused by the swine-adapted Salmonella enterica serovar Choleraesuis. Infected individuals remain healthy carriers, and if the infection occurs at the end of the fattening period, it could pose a threat to human health. The present work aimed to assess antimicrobial susceptibility of S. enterica serovar Choleraesuis serotypes isolated from domestic pigs in central-western Albania, and to assess the presence and circulation of antibiotic-resistant paratyphoid Salmonella in Albania. Increasing mortality was reported in 6 farrow-to-finish pig farms located in the western and central parts of the country from December 2022 to April 2023. Post-mortem examination revealed macroscopic lesions in different organs indicating Salmonella infection. Four serovars Choleraesuis were isolated out of 24 different Salmonella spp. Multi-drug resistance (MDR), extensively drug-resistant (XDR), and Pan Drug Resistance (PDR) was calculated. Three out of four isolates showed MDR, and one out of four showed XDR. All S. enterica serovar Choleraesuis isolates showed resistance to at least two antimicrobials. Three isolates were observed to display MAR index values >0.2 indicating high-risk contaminated sources with frequent use of antibiotics. The predominant antimicrobial resistance was observed for amoxicillin, oxytetracycline, sulfamethoxazole, trimethoprim, spiramycin, colistin sulpha, and doxycycline. The findings emphasize the importance of strict biosecurity measures in affected pig farms, and prevention and control of S. enterica serovar Choleraesuis in the farm sanitary programs in Albania.
AUTONOMOUS HEADING SENSORS NAVIGATION AND FLIGHT SYSTEMS AIRCRAFT
Authors: Скуднева О.В. 
Published: September 2024

Обоснована необходимость решения вопросов точной начальной выставки стояночного курса для решения задач навигации и пилотирования летательных аппаратов, в том числе в критических условиях эксплуатации. Охарактеризованы особенности начальной выставки курса в условиях средних широт и сложности определения стояночного курса в высоких широтах. Рассмотрены различные способы начальной выставки курса. Аргументировано применение транспортных беспилотных летательных аппаратов для различных целей. Предложено создание навигационно-пилотажных систем на основе курсовых и инерциальных систем с использованием бортовой цифровой вычислительной машины транспортных беспилотных и пилотируемых летательных аппаратов. Поскольку высокая точность начальной выставки курса и поддержание высокой точности текущего курса в полете – основные требования к навигационно-пилотажным системам, необходимо постоянно совершенствовать методы проведения начальной выставки, применительно к конкретным условиям эксплуатации летательных аппаратов.
The necessity of solving the problems of the exact initial exhibition of the parking course for solving the problems of navigation and piloting of aircraft, including in critical operating conditions, has been substantiated. The features of the initial exhibition of the course in conditions of middle latitudes and the complexity of determining the parking course in high latitudes are characterized. Various methods of initial course exhibition are considered. The use of transport unmanned aerial vehicles for various purposes is argued. The creation of navigation and flight systems based on course and inertial systems using an onboard digital computer for transport unmanned and manned aerial vehicles is proposed. Since the high accuracy of the initial course exhibition and maintaining the high accuracy of the current course in fl ight are the main requirements for navigation and aerobatic systems, it is necessary to constantly improve the methods of conducting the initial exhibition in relation to the specific operating conditions of aircraft.
Development of a Mathematical Model of an OLAP Cube for 1C: Enterprise
Authors: Захарова О.И. , Бедняк С.Г. , Головин А.В. 
Published: September 2024

В статье рассматривается математическая модель OLAP-куба. Для обеспечения скорости получения данных ОLАР-системы используют специальную структуру хранения данных, называемую кубом. Для более глубокого изучения описанной проблемы было рассмотрено устройство такого куба в системе «1С: Предприятие», проводится соотношение между кубом и регистром накопления в 1С. В рамках проводимого исследования была проведена связь между моделью и теорией решеток, представлена оптимальность представления OLAP-куба замкнутыми решетками. Были рассмотрены некоторые необходимые определения из теории решеток. Подробно описывается реализация связи куба в платформе 1С. На основании информации, описанной в статье, можно сделать некоторые выводы по данной теме. ОLАР-системы и 1С действительно можно совместить. В новых версиях конфигураций 1С реализована возможность добавления кубов, с помощью которых можно построить ОLАР-анализ данных. ОLАР-системы уже стремительно входят в современную жизнь компаний и предприятий, изменяя привычное представление о работе с информацией. Эти решения уже на сегодняшний день могут стать доступными пользователям 1С: Предприятие.
The article considers the mathematical model of an olap cube. To ensure the speed of data acquisition, OLAR systems use a special data storage structure called a cube. For a deeper study of the described problem, the device of such a cube in the 1C: Enterprise system was considered, the ratio between the cube and the accumulation register in 1C is carried out. In the framework of the study, a connection was made between the model and the theory of lattices, the optimality of the representation of the olap cube by closed lattices was presented. Some necessary definitions from lattice theory were considered. The implementation of the cube communication in the 1C platform is described in detail. Based on the information described in the article, some conclusions can be drawn on this topic. OLAR systems and 1C can really be combined. In new versions of 1C configurations, it is possible to add cubes with which you can build OLAR data analysis. OLAR systems are already rapidly entering the modern life of companies and enterprises, changing the usual idea of working with information. These solutions already today can become available to users of 1C: Enterprise.
THE IMPACT OF THE USE OF INFORMATION TECHNOLOGY ON THE ACCOUNTING PROFESSION IN THE ACCOUNTING LABOR MARKET IN THE KURDISTAN REGION, A FIELD STUDY OF PROFESSIONALS IN COMPANIES AND ACADEMICS IN ACCOUNTING DEPARTMENTS IN ERBIL GOVERNORATE
Authors: Ahmed Ramyar , Ibrahim Basm 
Published: September 2024

This study aims to explore the impact of the use of information technology on the accounting profession in the labor market in the Kurdistan Region, with a special focus on the opinions of professionals working in companies and academics in accounting departments in Erbil Governorate. The main problem addressed by the study is based on the challenge that accounting education faces in keeping pace with rapid developments in information technology and integrating them effectively within educational programs. In light of the significant expansion of the use of technology in various areas of life, including accounting, the urgent need for university accounting departments to provide the necessary scientific and practical skills to students is highlighted, to qualify them to work in an advanced technological accounting environment. Accordingly, the basic hypothesis of the study was formulated: “Using technology Information in accounting education raises the academic and professional competence of students in accounting departments, enabling them to keep pace with the requirements of the contemporary labor market in the Kurdistan region. To achieve the objectives of the study and examine the hypothesis, the descriptive analytical approach was adopted, which is suitable for studying the relationship between the use of information technology in accounting education and the competence of graduates. The descriptive aspect includes the use of relevant scientific literature and references, while in the analytical aspect, data is collected through questionnaires directed to a sample of the study, and analyzed using the Statistical Package for the Social Sciences (SPSS) program. The results highlight the importance of information technology in accounting and confirm the existence of a relationship There is a strong connection between the technological qualification of accountants and the actual reality of their profession in the region. Therefore, the study recommends the need to pay attention to continuously evaluating accounting educational programs and developing them to meet the changing needs of the labor market, including providing specialized training courses in information technology, modernizing the technological infrastructure, and enhancing cyber security for data. Accounting. These measures will contribute to improving the competence and skills of accounting graduates tobetter prepare them to face contemporary challenges in the accounting profession.
Profile of adult care classified as non-urgent in emergency care unit
Authors: Magalhães Danielle de Fátima , Nunes Mario Gilberto Jesus , Silva Junio Cesar da 
Published: September 2024

Objective: To identify the profile of care classified as non-urgent in the Emergency Care Unit (ECU). Methods: This is a descriptive, retrospective, documentary study with a quantitative approach, carried out in an ECU located in the city of Curitiba, PR, with users from 18 years of age and blue priority in the risk classification. Data were tabulated in Excel® and analyzed in SPSS® to obtain descriptive statistics, inferences and perform the chi-square test. Results: 213 medical records were analyzed, predominantly looking for young adults, with a mean age of 39 years, female. The main clinical complaints/demands reported (p<0.001) by users were: respiratory and flu problems (36%), followed by medication administration (14%) and unprotected sexual exposure (8%). Morning calls (39%) were more frequent (p<0.001), with Monday and Wednesday being the days with the highest demand (p=0.026). The most common outcome of the consultations was discharge from the unit (61%; p<0.001). Conclusion: The care of adults up to 39 years old predominated, with greater demand during the day. The clinical complaints and demands presented were not compatible with the profile and complexity intended for an urgent and emergency service.
Honour Killing in India and role of Khap Panchayats
Authors: Deepak Malik  , Prof. Harsh Purohit  
Published: September 2024

A horrific example of cultural customs and society standards that put family honour ahead of personal freedom and rights are honour murders. throughout spite of societal disapproval and legal restrictions, these heinous crimes—which are mostly committed against women—recur throughout India. Examining the issue of honour murders in India, this study focuses especially on the important role that traditional caste-based councils known as Khap Panchayats play in rural areas.
Honour murders are first contextualised in the study within the larger framework of patriarchal systems and deeply ingrained gender norms that characterise Indian culture. It also emphasises how political and law enforcement officials in the area have allowed honour killing offenders to operate with impunity, therefore highlighting the systemic character of the issue. The report also looks at community-based awareness programmes, grassroots activity, and legislative actions meant to stop honour murders and question Khap Panchayat power. It underlines the need of confronting underlying sociocultural beliefs and enabling underprivileged people—women in particular—to stand up for their rights and oppose repressive policies.
This study emphasises how urgently multidimensional approaches—including legislative changes, societal mobilisation, and educational programmes meant to question regressive norms and undermine caste-based oppressive systems—are needed to end honour murders in India. It urges coordinated measures to hold offenders and their supporters responsible and to promote gender equality and human dignity.
Study of Patients’ Satisfaction with different types of Telemedicine Services provided by the Ministry of Health in Saudi Arabia
Authors: Waleed Salem Alghamdi  , Abdulrahman Owaynan Alshaibani  , Turki Ghazi Alotaibi  
Published: September 2024

One way to gauge the quality of healthcare is to look at how satisfied patients are with the system overall. Finding out how happy patients are with various telemedicine services offered by Saudi Arabia's Ministry of Health is the main goal of this research. The satisfaction of Saudi Arabian customers using telemedicine services was assessed in a cross-sectional survey. Customers of the 940 medical contact centre and the Sehha app, two telemedicine services, were surveyed using a rigorous random selection technique. Two hundred and fifty users of the 940 medical contact centre and the Sehha app were selected at random to fill out a pre-designed survey about their level of satisfaction with various aspects of the two health services. Out of 250 people who used telemedicine services, 83.14 percent were happy with the care they received overall, while 8.03 percent were unhappy. These days, telemedicine apps are employed by a lot of wealthy nations and even some underdeveloped ones to help provide healthcare to people faster for all sorts of medical issues. In Saudi Arabia, telemedicine services generally had good satisfaction ratings, with no discernible variation in ratings between the 940 medical contact centre and the Sehha app. Customers who used telemedicine services were generally pleased and were even willing to recommend them to others.
A Study of the Saudi Arabian Emergency Medical Services' performance in both rural and urban locations is influenced by organisational factors
Authors: Rakan Hassan Alenazi  , Maha Abdulmohsen Alanazi  , Saeed Mohammed Alnasim  , Abdulelah Hulail Almalki  , Fahad Mohammed Almudara  
Published: September 2024

Background: This study explores into the investigation of the impact of organisational elements on the performance of Saudi Arabian EMS in various contexts, including rural & urban areas. The current research aims to learn more about the organisational variables that may explain why EMS performance differs in urban or rural areas from the perspectives of frontline personnel. Method: Researchers in Saudi Arabia's Riyadh region carried out the study. Participants were required to have worked for the Saudi Red Crescent EMS for at least 5 years and be currently engaged in one of the following roles: technician, paramedic, or EMS station manager. The first participants who responded to the call for participation were interviewed using semi-structured interviews from October 2021 to July 2022. The process proceeded until all data is acquire. We will analyse the data using analysis methodology. Results: Forty people from the Saudi Red Crescent EMS are a part of the final sample (20 from rural areas and 20 from urban centres). The data analysis is reveal important organisational characteristics that caused EMS staff to face obstacles & hurdles. There were also some similarities. Conclusion: Results showed that EMS performance is negatively affected in both urban & rural locations.
उच्च शिक्षा के छात्रों में डिजिटल मीडिया के उपयोग का मूल्यांकन: टेलीविजन एवं वेब मीडिया के बीच एक तुलनात्मक अध्ययन
Authors: अभिषेक यादव  , डॉ. आशुतोष वर्मा  
Published: September 2024

- व्यक्तियों में डिजिटल मीडिया के प्रति आकर्षण अत्यंत गहरा है विद्यार्थियों को विभिन्न स्थानों पर आते-जाते हुए डिजिटल मीडिया के विभिन्न माध्यमों को प्रयोग में लाया जा रहा विशेष तौर पर वीडियो गेम खेलने अथवा शो स्ट्रीम करते हुए देखा गया है। देश विदेश कि खबर पढ़ रहे है | डिजिटल मीडिया को सरल शब्दों में परिभाषित करना अत्यंत ही कठिन है क्योंकि यह प्रौद्योगिकी में नवाचारों के साथ-साथ तेजी से विकसित हो रहा है। जैसे-जैसे हम भविष्य में आगे बढ़ेंगे, डिजिटल मीडिया का हमारा दैनिक उपयोग बढ़ेगा, विशेष रूप से होलोग्राफिक और कृत्रिम बुद्धिमत्ता (एआई) प्रौद्योगिकियों के विकसित होने और हमारे दैनिक जीवन में शामिल होने के कारण। प्रस्तुत शोध कार्य हायर सेकेंडरी में अध्ययनरत विद्यार्थियों द्वारा डिजिटल मीडिया के बढ़ते उपयोग का उनके विभिन्न जनसांख्यिकीय के अनुसार मूल्यांकन करने के उद्देश्य से किया जा रहा है। जिसमे भोपाल शहर में शासकीय एवं गैर शासकीय विद्यालयों में अध्ययनरत विद्यार्थियों को सम्मिलित किया गया है।
Women Empowerment in India
Authors: Geeta  
Published: September 2024

Women's empowerment is a contentious issue. Women enjoyed equal status and power to men throughout the earlier Stone Age period. However, during the post-Vedic and epic times, they began to have certain challenges. History demonstrates that women were frequently treated like slaves. The standing of women has been progressively shifting from the early 20th century (national movement), and the British people are to thank for this. It is only after the Independence of India, under the able leadership of Dr. Ambedkhar , the constitutional makers and national leaders started strongly demanding and also reiterating the equal social position of women with men. it is good to learn that a few number of women have been able to establish their potentialities. Therefore, this paper suggests that each and every human being should be careful in taking steps to promote the statuses of women and respect their dignity