bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relevance of hydraulic modelling in planning and operating real-time pressure control: case of Oppegård municipality
Authors: Berardi Luigi , Simone Antonietta , Laucelli Daniele B. , Ugarelli Rita M. , Giustolisi Orazio 
Published: December 2017

Abstract
Technical best practices recommend pressure control as an effective countermeasure to reduce leakages in water distribution networks (WDNs). Information and communication technologies allow driving pressure reducing valves (PRVs) in real-time based on pressure observed at remote control nodes (remote real-time control – RRTC), going beyond the limitations of classic PRV control (i.e. with target pressure node just downstream of the device). Nowadays, advanced hydraulic models are able to simulate both RRTC-PRVs and classic PRVs accounting for unreported and background leakages as diffused pressure-dependent outflows along pipes. This paper studies how such models are relevant to support pressure control strategies at both planning and operation stages on the real WDN of Oppegård (Norway). The advanced hydraulic model permits demonstration that RRTC-PRVs in place of existing classic PRVs might reduce unreported and background leakages by up to 40%. The same analysis unveils that advanced models provide reliable evaluation of leakage reduction efforts, overcoming the inconsistencies of lumped indexes like the Infrastructure Leakage Index (ILI). Thereafter, the model allows comparison of three strategies for the real-time electric regulation of PRVs in some of the planned scenarios, thus supporting real-time operation of RRTC-PRVs.
Climatic and atmospheric indices teleconnection impact on the characteristics of frost season in western Iran
Authors: Maryanaji Zohreh , Tapak Leili , Hamidi Omid 
Published: December 2017

Abstract
The large-scale variability of atmospheric and ocean circulation patterns cause seasonal climate changes in the Earth. In other words, climate elements are affected by phenomena like El Niño Southern Oscillation (ENSO), El Niño (NINO), and Northern Atlantic Oscillation (NAO). In this study the characteristics of the frost season over a 20-year period (1996–2015) from seven synoptic stations in western Iran were evaluated using support vector machine and random forest regression. Comparing determination coefficients obtained by these models between atmospheric and ocean circulation indices and the characteristics of the frost season showed a positive effect. Thus, the onset and the end of the frost season in this region were highly correlated with the Southern Oscillation Index (SOI) and NAO, respectively. In regions with lower correlations (central areas and some regions of Alvand Mountain), the role of the geographical factors, altitude and topography becomes more pronounced and the impact of the global indices is reduced. Cluster analysis was also conducted to detect patterns and to identify regions according to the effect of the atmospheric and oceanic indices on frost season, and three regions were identified. The largest correlations with global indices (in both models) belonged to the first and third classes, respectively. The results of this study could be applied for planning environmental and agricultural activities.
Putative Mechanisms of Action and Clinical Use of Lithium in Children and Adolescents: A Critical Review
Authors: Pisano Simone , Pozzi Marco , Catone Gennaro , Scrinzi Giulia , Clementi Emilio , Coppola Giangennaro , Milone Annarita , Bravaccio Carmela , Santosh Paramala , Masi Gabriele 
Published: December 2017

Background:Lithium is a first-line treatment for bipolar disorder in adults, but its mechanism of action is still far from clear. Furthermore, evidences of its use in pediatric populations are sparse, not only for bipolar disorders, but also for other possible indications.Objectives:To provide a synthesis of published data on the possible mechanisms of action of lithium, as well as on its use in pediatric samples, including pharmacokinetics, efficacy, and safety data.Methods:Clinical trials in pediatric samples with at least one standardized measure of efficacy/ effectiveness were included in this review. We considered: i) randomized and open label trials, ii) combination studies iii) augmentation studies iv) case series including at least 5 patients.Results:Different and non-alternative mechanisms of action can explain the clinical efficacy of lithium. Clinical studies in pediatric samples suggest that lithium is effective in managing manic symptoms/episodes of bipolar disorder, both in the acute phase and as maintenance strategy. Efficacy on depressive symptoms/phases of bipolar disorder is much less clear, while studies do not support its use in unipolar depression and severe mood dysregulation. Conversely, it may be effective on aggression in the context of conduct disorder. Other possible indications, with limited published evidence, are the acute attacks in Kleine-Levin syndrome, behavioral symptoms of X-fragile syndrome, and the management of clozapine- or chemotherapy- induced neutropenia. Generally, lithium resulted relatively safe.Conclusions:Lithium seems an effective and well-tolerated medication in pediatric bipolar disorder and aggression, while further evidences are needed for other clinical indications.
Analytical QbD: Designing Space for HPLC Method Operable Region for Estimation of Preservatives in Herbal Formulation
Authors: Patel Kalpana , Patel Hinal Jitendrabhai , Christian Jenee , Hingorani Lal , Gandhi Tejal 
Published: December 2017

Background:
Quantification of preservatives in herbal formulation, simultaneously by high
performance liquid chromatography analysis is very complex and involves series of steps including
sample preparation, selection of suitable mobile phase and its validation for routine applications.
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Introduction: Application of Quality by Design (QbD) in the development of novel, simple, accurate
and precise RP-HPLC method for concurrent quantification of quaternary preservatives in herbal formulation,
focusses on development of robust method.

Methods:
Isocratic analysis was carried out using C18 column at 231 nm. Risk assessment studies were
executed to determine the critical method parameters which were defined as acetonitrile volume in the
mobile phase, volume of injection and orthophosphoric acid concentration in the mobile phase. The
effect of the critical method parameters on critical method attributes, i.e. retention time, resolution and
chromatographic optimization function was further evaluated by means of central composite design and
the optimal conditions were determined through derringer’s desirability approach of multi-criteria decision
making technique.

Results:
The method was statistically validated according to ICH guidelines having good resolution
using optimized mobile phase, acetonitrile: 0.11% orthophosphoric acid in water (12.30: 87.70 % v/v)
giving acceptable retention time i.e. 3.7128 ± 0.0138 of bronopol, 4.5106 ± 0.00542 of sodium propyl
paraben, 10.7228 ± 0.029 of sodium benzoate and 12.252 ± 0.027 of sodium methyl paraben.

Conclusion:
Hence, the QbD based method development assisted in generating a design space with
knowledge of all method performance characteristics leading to a better understanding of the method,
and achieving desirable method quality.
Anticancer Activity of Resorcinarene-PAMAM-Dendrimer Conjugates of Flutamide
Authors: Pedro-Hernández Luis D. , Martínez-Klimova Elena , Martínez-Klimov Mark E. , Cortez-Maya Sandra , Vargas-Medina Ana C. , Ramírez-Ápan Teresa , Hernández-Ortega Simón , Martínez-García Marcos 
Published: December 2017

Methods: The synthesis of conjugates of flutamide with resorcinarene-PAMAM-dendrimers as well
as alkyl and ethyl phenyl chains in the lower part of the macrocycle as a nucleus and diethylenetriamines in the
dendritic branches gives the opportunity to obtain conjugates in one step of synthesis with 16 and 64 flutamide
moieties in the structure.

Results:
The in vitro anticancer studies showed that the conjugates of flutamide are more active than the free
flutamide and the flutamide derivatives, thus diminishing the amount of flutamide used. The resorcinarenedendrimer-
flutamide conjugates with a high drug payload improve the activity of the drug.

Conclusion:
This is important in delivering a sufficient amount of flutamide and suggests that the dendrimer
facilitates more of the drug being introduced into cells. It was also observed that the new conjugates are less
toxic than the anti-androgens.
Relevansi Kompetensi Teknik Gambar Manufaktur di SMK Terhadap Kebutuhan Industri
Authors: Arifin Ahmad Nur , Ristadi Febrianto Amri 
Published: December 2017

This research aims to identify the relevance of competency of manufacture drawing subject at SMK Muhammadiyah 2 Jatinom compared to the industrial competency needs. The research is a descriptive research. The subjects of the study were students, a teacher of manufacture drawing subject, and drafters working in the manufacturing industry. Questionnaires were used as data collection method. Data were analyzed using statistical descriptive analysis by percentages. The result shows that the relevance of competency of manufacture drawing subject to the industrial competency needs is 74.3%, which is in the category of “medium” relevancy. The learning materials of manufacture drawing subject being taught to the students is 52.3% (highly relevant), while the learning materials itself is 47.7% (medium relevancy).Tujuan penelitian ini adalah untuk mengetahui relevansi kompetensi mata pelajaran Teknik Gambar Menufaktur di SMK Muhammadiyah 2 Jatinom dengan kebutuhan kompetensi di industri. Penelitian ini merupakan peneltian deskriptif. Subjek penelitian ini adalah siswa, guru Teknik Gambar Menufaktur dan drafter pada industri manufaktur. Metode pengumpulan data menggunakan angket. Analisa data yang digunakan adalah statistik analisis deskriptif dengan persentase. Hasil penelitian menunjukkan bahwa relevansi kompetensi mata pelajaran Teknik Gambar Menufaktur di SMK Muhammadiyah 2 Jatinom terhadap kompetensi kebutuhan industri adalah sebesar 72% dan termasuk dalam kategori cukup relevan. Materi yang sudah diperoleh oleh siswa tentang mata pelajaran TGM 52,3% yang termasuk kategori sangat relevan, sedangkan 47,7% materi yang diperoleh siswa termasuk kategori cukup relevan.
Analisis Faktor-Faktor Penghambat Produktivitas Publikasi Karya Ilmiah Mahasiswa PPs UNY pada Jurnal Internasional Terindeks
Authors: Pardjono Pardjono , Nuchron Nuchron , Surono Surono , Ramdani Sulaeman Deni 
Published: December 2017

This research aims to reveal the inhibiting factors affecting the productivity of scientific papers publication of UNY graduate school students on indexed international journals, and students’ expectation for the school administration to increase that productivity. This is a survey research carried out by the Graduate School of Universitas Negeri Yogyakarta (PPs UNY), involving 74 respondents. Data were obtained by means of questionnaire and were analyzed using descriptive statistical analysis. The results can be stated as follows. 1) The inhibiting factors came from external factors, namely busy workload, the high cost of international publishing, limited resource and access to printed journals subscription, and limited resource of online journals subscription. 2) Students’ expectation to increase the productivity of indexed international journals publication are improvement in the dissemination of the program, access to information and services, English writing course, free translation, establish cooperation and networking, and subscription of online and printed journals.Penelitian ini bertujuan untuk mengungkap: 1) faktor penghambat produktivitas mahasiswa dalam publikasi karya ilmiah pada jurnal internasional terindeks, 2) harapan mahasiswa kepada pengelola kampus untuk meningkatkan produktivitas publikasi karya ilmiah dalam jurnal internasional terindeks. Penelitian ini merupakan penelitian survei yang dilakukan di Program Pascasarjana Universitas Negeri Yogyakarta (PPs UNY) dengan responden berjumlah 74 orang. Teknik pengumpulan data menggunakan angket. Teknik analisis data menggunakan teknik analisis statistik deskriptif. Hasil penelitian dijelaskan sebagai berikut. 1) Faktor penghambat publikasi karya ilmiah pada jurnal internasional terindeks bersumber dari faktor eksternal yaitu kesibukan kerja, besarnya biaya, terbatasnya langganan jurnal cetak, terbatasnya langganan jurnal online, dan terbatasnya akses jurnal cetak. 2) Harapan Mahasiswa PPs UNY untuk meningkatkan produktivitas publikasi karya ilmiah dalam jurnal internasional terindeks yaitu perbaikan dan peningkatan dalam sosialisasi, akses informasi dan layanan, pelatihan penulisan dan bahasa Inggris, bantuan alih bahasa secara gratis, menjalin kerjasama dengan berbagai pihak, serta langganan jurnal online dan cetak
Democratic Pedagogy
Authors: Burgh Gilbert 
Published: December 2017

The ideas contained in this paper were first formulated as part of a chapter in my doctoral dissertation, which was completed in 1997. Some years later I added to my initial thoughts, scribbled some notes, and presented them at the 12th Annual Philosophy in Schools Conference, held in Brisbane in 2002. This presentation surfaced as a paper in Critical & Creative Thinking: the Australasian Journal of Philosophy in Schools (Burgh 2003a). Soon thereafter I revised the paper (Burgh 2003b) and it appeared in abridged form in the Asia-Pacific Philosophy Education Network for Democracy (APPEND) Philosophy Series, Volume 4: Philosophy, Democracy and Education, edited by Philip Cam. It was once again revised, but also expanded, and appeared in Chapter 5 of Ethics and the community of inquiry: Education for deliberative democracy, a collaborative authorship with Terri Field and Mark Freakley (2006). Some sections have been further revised and appear in other publications (Burgh 2009, 2010; Burgh & Yorshansky 2011). These revisions would suggest that my thoughts on these matters are constantly changing. To some degree this is true, but each time the changes have built on previous ideas rather than new ideas replacing old ones. I welcomed the invitation to revise the original paper, which includes sections not included in later versions. However, with almost 11 years passing since the original publication, I found myself deleting sections and replacing others. Subsequently, this paper is a culmination of all the revisions and incorporates ideas from each.
Book review - Philosophy in schools: An introduction for philosophers and teachers
Authors: D'Olimpio Laura 
Published: December 2017

Philosophy in Schools: An introduction for philosophers and teachers edited by Sara Goering, Nicholas J Shudak and Thomas E Wartenberg (2013). (Routledge Studies in Contemporary Philosophy) Taylor & Francis, New York, NY. ISBN: 9780415640633. The edited collection Philosophy in Schools: An introduction for philosophers and teachers is exactly that; an introduction to the central ideas of the Philosophy in Schools movement, with tips and strategies as to how to implement Philosophy for Children (P4C) in your classroom or educational space. With 25 chapters, this handy edition includes the writings of 31 academics and well known practitioners of P4C worldwide. While all the voices contributing to this volume are positive and optimistic as they exalt the benefits of P4C, the diversity comes in the form of the various ways in which the numerous authors have practiced philosophy with participants of different ages, cultural and socio-economic backgrounds. There is a mix of theory and pedagogy, with a focus on the pragmatic reality of doing philosophy with young people.
Peningkatan Pengetahuan Terkait Hipertensi Guna Perbaikan Tekanan Darah pada Pemuda di Dusun Japanan, Margodadi, Seyegan, Sleman, Yogyakarta
Authors: Sudarsono Erica Kusuma Rahayu , Sasmita Julius Fajar Aji , Handyasto Albertus Bayu , Kuswantiningsih Natalia , Arissaputra Stefanus Sofian 
Published: December 2017

Prevalence of hypertension in Indonesia has reached 25.8%; Yogyakarta is the third largest prevalence in Indonesia, and hypertension in Seyegan sub-district is ranked first most diagnosed. Hypertension can lead to an increased risk of cardiovascular diseases such as heart attacks and strokes. Knowledge related to hypertension of residents, especially youth is still quite low. Youth is provided with education and training on how to measure blood pressure and basic knowledge related to hypertension. The education was done by discussion using Focus Group Discussion (FGD) method, then youth made program to overcome hypertension problem. Conducted blood pressure screening and interviews about the lifestyle of residents to determine the cause of hypertension. Blood pressure screening and interviews were analyzed by chi square or fisher, increased youth knowledge from pre-test and post-test analyzed with kolmogorov-smirnov and analyzed by paired T test with 95% confidence level. There was no significant effect between BMI, education and exercise on blood pressure, but there was a significant influence between smoking and consumption of foods high in salt and fat to blood pressure. The results of pre-test and post-test showed an increase in youth knowledge from the beginning only 5.27 to 7.37 with p-value 0.000 (p <0.05). Provision of education to youth increases the level of knowledge related to hypertension.
Knowth passage-grave in Ireland: An instrument of precision astronomy?
Authors: Prendergast Kate 
Published: December 2017

Knowth is one of three large monuments at the Neolithic complex in the bend of the River Boyne in County Meath, Ireland. The others are Newgrange and Dowth. All three have obvious solar alignments but whereas the alignment to the winter solstice sunrise at Newgrange has been extensively researched and interpreted, little has been attempted regarding the way that astronomy functions at Knowth and Dowth. This paper treats the evidence for solar and lunar alignments at Knowth.
Knowth has two internal passages with entrances at the east and west. The paper draws on new surveys as well as interpretations of the evidence at Knowth that includes rock art engraved on kerbstones around the circumference. Particular engravings on kerbstone K52 are interpreted as depicting astronomical cycles. It is argued that, while Knowth’s passages function in relation to the equinoxes, they are not internally orientated to match exactly the equinoctial directions. Rather, it seems that they may have been constructed and used to facilitate the harmonisation of the solar and lunar cycles - much in the same way as does the equinoctial Judeo-Christian festival of Easter. The paper concludes by suggesting that like Newgrange, Knowth may be an astronomical instrument that enabled its builders and users to construct accurate calendars and counting systems, which in turn facilitated calculated planning and was a fundamental structuring principle for their ritual lives and cosmological beliefs.
Escola técnica, conhecimento integrado e politecnia
Authors: Rocha Ione Dos Santos , De Almeida José Rubens Mascarenhas 
Published: December 2017

O artigo aqui apresentado objetiva discutir a trajetória das escolas técnicas brasileiras diante da proposição de ensino integrado da legislação vigente e aprofunda a discussão acerca da politecnia como proposta de superação da dualidade entre trabalho intelectual e manual. A partir deste objetivo, são analisadas as contradições, desde o surgimento à distribuição, das instituições públicas de ensino técnico e a trajetória do estabelecimento desta rede de ensino até a atualidade, retratando a apropriação política da educação como mecanismo de promoção das demandas econômicas. Nesse sentido, o debate acerca do conceito de politecnia, que corresponde a uma concepção de educação mais profunda a partir da apropriação da tecnologia como conhecimento e produção social, é um desafio dos cursos técnicos integrados em vigor nas escolas atuais.
PENGARUH HAMBATAN DOWNSTREAM TERHADAP KARAKTERISTIK PEMISAHAN FASE KEROSENE-AIR PADA T-JUNCTION 90O
Authors: Dharma Untung Surya , Sari Dewi Puspita , Indarto Indarto , Purnomo Purnomo 
Published: December 2017

Research on T-Junction as a separator of liquid-liquid flow is still of interest and developing. Some works evaluated certain geometries to obtain the best separation efficiency. The work to examine the separation behavior/characteristic of kerosene-water flow in a T-Junction at ratio of elbow radius to inlet diameter horizontal pipe (r/Dh) = 0.69 carried out is completed. The orientation of side arm is vertically right upward whilst the ratio at diameter of the flex glass tube is set at 0.7 (horizontal tube and vertical tube at 36 mm and 26 mms respectively). To lead kerosene to the side arm, the downstream valve set at 75% and 50% respectively. Downstream pressure, pressures difference at inlet-run arm (∆P1-2) and inlet-side arm (∆P1-3) and debit of kerosene and water in side and run arm are the variable at the research. Based on visualization and measurement at maximum flow separation efficiency at 88%, is gained at downstream pressure 104326 Pa, watercut 46%, Jmix = 0,31 m/s (Jw = 0,14 m/s and Jk = 0,17 m/s). The best separation result with Fk = 0,96 and Fw = 0,22 is gained at downstream pressure 104287 Pa, watercut 70%, Jmix = 0,56 m/s (Jw = 0,39 m/s and Jk = 0,17 m/s) and flow pattern at Stratified Bubble Interface (ST-BI)
PENGARUH VARIASI BEBAN TERHADAP EFISIENSI SOLAR CELL DENGAN KAPASITAS 50 WP
Authors: Rusman Rusman 
Published: December 2017

Efek krisis energi di Indonesia masih sangat dirasakan oleh masyarakat Indonesia. Energi listrik menjadi kebutuhan yang sangat penting bagi masyarakat, sejalan dengan meningkatnya laju pertumbuhan penduduk dan pembangunan di segala bidang. Sebagai upaya untuk memenuhi kebutuhan tenaga listrik tersebut sekaligus penanggulangan kondisi krisis penyediaan tenaga listrik di beberapa daerah, maka dapat memanfaatkan Potensi alam untuk dijadikan energi listrik. Salah satu Potensi alam sebagai sumber energi listrik adalah energi tenaga matahari. Matahari merupakan sumber energi utama bagi sebagian besar proses-proses yang terjadi dipermukaan bumi. Tujuan penelitian ini akan menghasilkan efisiensi solar cell dengan metode penelitian yang menggunakan beberapa beban yaitu 3 watt, 6 watt dan 9 watt dalam mempengaruhi efisiensi solar cell. Efisiensi dengan menggunakan waktu pengambilan data dari jam 08.00 sampai dengan 17.00. Hasil yang didapatkan yaitu untuk beban 3 watt yaitu menghasilkan efisiensi 84 % dan untuk beban 6 watt yaitu menghasilkan efisiensi 90 % serta beban 9 watt menghasilkan menghasilkan efisiensi 86 % sehingga disimpulkan bahwa efisiensi solar cell dengan kapasitas 50 WP maksimum pada jam 12.00 siang.