bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microsurgical Resection of Tuberculum Sellae Meningioma through Left Cranio-orbital Approach
Authors: Pojskić Mirza , Arnautović Kenan 
Published: January 2018

AbstractIn this video clip, the authors present the resection of a tuberculum sellae meningioma with compression of the left optic nerve and a chiasm (Fig. 1) through a standard cranial orbital (CO) skull base approach.1
2
3 The key step in the tumor resection was microsurgical dissection of left and right A1 segments of the anterior cerebral artery and the anterior communicating artery and the separation of the tumor from these vascular structures. This was followed by careful separation of the meningioma from both optic nerves, the chiasm and the pituitary stalk. The final step was coagulation and resection of the tumor origin on the dura of the tuberculum sellae, devascularizing the tumor. Once this was achieved, the tumor was removed. Using this approach, an optimal surgical corridor to the sellar area was provided while minimizing the retraction of frontal and temporal lobes.The link to the video can be found at: https://youtu.be/O59Fj2dNXB0.
Endoscopic Transsphenoidal Resection of Craniopharyngioma
Authors: Liew Kong , Narayanan Prepageran , Waran Vicknes 
Published: January 2018

Objectives To demonstrate, step-by-step, the technique and efficacy of endoscopic transsphenoidal approach in resection of a suprasellar craniopharyngioma.
Design The video shows a step-by-step approach to the resection, covering the exposure, access, resection, and confirmation of resection and reconstruction.
Setting The surgery was performed in the University of Malaya Medical Centre, a tertiary referral center in the capital of Malaysia.
Participants Surgery was performed jointly by Professor Prepageran from the department of otorhinolaryngology and Professor Vicknes Waran from the division of neurosurgery. Both surgeons are from the University of Malaya. Video compilation, editing, and voice narration was done by Dr. Kong Yew Liew.
Main Outcome Measures Completeness of resection and avoidance of intra- and postoperative complications.
Results Based on intraoperative views and MRI findings, the tumor was completely resected with the patient suffering only transient diabetes insipidus.
Conclusion Central suprasellar tumors can be removed completely via an endoscopic transsphenoidal approach with minimal morbidity to the patient.The link to the video can be found at: https://youtu.be/ZNIHfk12cYg.
Resection of an Optic Canal Meningioma through a Contralateral Subfrontal Approach with Endoscopic Assistance: A 2D Operative Video
Authors: Labidi Moujahed , Watanabe Kentaro , Bernat Anne-Laure , Hanakita Shunya , Froelich Sébastien 
Published: January 2018

Objective To review the use of the contralateral subfrontal approach for the resection of an optic canal meningioma.
Design Operative video.
Results A meningioma, located in the inferomedial side of the optic canal (Fig. 1), was found to cause significant visual deterioration. The subfrontal route was preferred to expose the tumor without mobilization of the optic nerve. Drilling of the anterior limb of the chiasmatic sulcus (limbus sphenoidale) provided adequate exposure of the medial aspect of the optic canal. Gross total resection (Simpson II) of the tumor was accomplished, and endoscopic assistance allowed identification and coagulation of an infiltrated dura mater in the chiasmatic sulcus and tuberculum sellae.
Conclusion The subfrontal approach grants an optimal surgical trajectory to the contralateral chiasmatic sulcus and optic nerve. When the medial side of the optic canal is drilled, tumors extending into the optic canal can be safely resected, under direct visualization of the inferomedial side of the optic nerve. Breach into the sphenoid sinus can occur during drilling of the anterior limb of the chiasmatic sulcus. Endoscopic assistance can provide a better view on blind areas of the surgical field, including the depth of the optic canal (Fig. 2).The link to the video can be found at: https://youtu.be/fS2udUCPH1g.
Infrasellar Endoscopic Endonasal Approach for a Pituitary Adenoma Extending into the Third Ventricle, with Anterior Displacement of the Pituitary Gland
Authors: Zenonos Georgios , Wang Eric , Fernandez-Miranda Juan 
Published: January 2018

Objectives The current video presents the nuances of the infrasellar endoscopic endonasal approach for a pituitary adenoma extending into the third ventricle, with anterior displacement of the pituitary gland.
Design The video analyzes the presentation, preoperative workup and imaging, surgical steps and technical nuances of the surgery, the clinical outcome, and follow-up imaging.
Setting The patient was treated by a skull base team consisting of a neurosurgeon and an ENT surgeon at a teaching academic institution.
Participants The case refers to 73-year-old female patient who was found to have a sellar mass after failure of vision to improve with cataract surgery. She also reported a several-month history of progressive loss of vision along with daily retro-orbital headaches. The adenoma extended into the clivus as well as in the retrosellar and suprasellar regions, eroding into the floor of the third ventricle. The normal gland was displaced anteriorly.
Main Outcome Measures The main outcome measures consisted of reversal of patient symptoms (headaches and visual disturbance), recurrence-free survival based on imaging, as well as absence of any complications.
Results The patient's headaches and visual fields improved. There was no evidence of recurrence.
Conclusion The infrasellar endoscopic endonasal approach is safe and effective for pituitary adenomas extending into the third ventricle, with anterior displacement of the pituitary gland.The link to the video can be found at: https://youtu.be/zp_06mEyRvY.
Approach to Infants Born Through Meconium Stained Amniotic Fluid: Evolution Based on Evidence?
Authors: Nangia Sushma , Chandrasekharan Praveen , Lakshminrusimha Satyan , Rawat Munmun 
Published: January 2018

AbstractMeconium-stained amniotic fluid (MSAF) during delivery is a marker of fetal stress. Neonates born through MSAF often need resuscitation and are at risk of meconium aspiration syndrome (MAS), air leaks, hypoxic-ischemic encephalopathy, extracorporeal membrane oxygenation (ECMO), and death. The neonatal resuscitation approach to MSAF has evolved over the last three decades. Previously, nonvigorous neonates soon after delivery were suctioned under the vocal cords with direct visualization technique using a meconium aspirator. The recent neonatal resuscitation program (NRP) recommends against suctioning but favors resuscitation with positive pressure ventilation of nonvigorous neonates with MSAF. This recommendation is aimed to prevent delay in resuscitation and minimize hypoxia-ischemia often associated with MSAF. In this review, we discuss the pathophysiology, evolution and the evidence, randomized control trials, observational studies, and translational research to support these recommendations. The frequency of ECMO use for neonatal respiratory indication of MAS has declined over the years probably secondary to improvements in neonatal intensive care and reduction of postmaturity. Changes in resuscitation practices may have contributed to reduced incidence and severity of MAS. Larger randomized controlled studies are needed among nonvigorous infants with MSAF. However, ethical dilemmas and loss of equipoise pose a challenge to conduct such studies.
Volar Locking Plate Fixation of Distal Radius Fractures: Splint versus Immediate Mobilization
Authors: Duprat André , Diaz Juan , Vernet Paul , Gouzou Stéphanie , Facca Sybille , Igeta Yuka , Liverneaux Philippe 
Published: January 2018

Background The goal of this study was to demonstrate that the use of a splint after performing an osteosynthesis of the distal radius with a volar locking plate is unnecessary. The main hypothesis was that postoperative flexion of the wrist was greater without a splint. Secondary hypothesis was that patients who were allowed immediate mobilization got better results in terms of pain, Quick Disabilities of the Arm, Shoulder and Hand (DASH), Patient-Rated Wrist Evaluation (PRWE), strength, extension, pronation, and supination.
Case Description Our series included 72 patients, aged 59 years in average of which 59 were female patients. All patients had been operated for a volar locking plate fixation of a distal radius fracture. The first 36 patients (group I) were immobilized by a splint at 30° of extension of the wrist for 2 weeks. The following 36 patients (group II) were not immobilized.
Results At 3 months, all the average variables were better in the group without splint (group I: flexion 74.83%, extension 83.13%, pronation 92.07%, supination 88.11%, pain 1.72/10, Quick DASH 21.78/100, PRWE 22.97/100, strength 62.96%; group II: flexion 85.50%, extension 83.4%, pronation 92.96%, supination 92.96%, pain 1.28/10, Quick DASH 19.57/100, PRWE 20.56/100, strength 66.34%). No complication was reported.
Conclusion Overall, our results demonstrate that wearing a splint after volar locking plate fixation of a distal radius fracture is unnecessary.
Endoscopic ultrasound-guided choledochoduodenostomy using partially-covered self-expandable metal stent in patients with malignant distal biliary obstruction and unsuccessful ERCP
Authors: Rai Praveer , Lokesh CR , Goel Amit , Aggarwal Rakesh 
Published: January 2018

Abstract
Background and study aims Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) is an alternative to percutaneous transhepatic biliary drainage (PTBD) for patients with malignant distal biliary obstruction in whom ERCP has failed. We studied technical success, clinical success, stent patency rate and occurrence of adverse events in patients undergoing EUS-CDS with partially-covered self-expanding metal stent (PCSEMS).
Patients and methods Medical records of consecutive patients with unresectable malignant distal biliary obstruction requiring biliary drainage who underwent EUS-CDS because of failure of attempt at ERCP were reviewed. EUS-CDS was done using 6-cm, PCSEMS (Wallflex, Boston Scientific). Technical success, clinical success (more than 50 % reduction in total bilirubin at 2 weeks post-procedure), stent patency rate and adverse events (AEs) were assessed. Patients were followed up for 3 months post-procedure.
Results Between January 2015 and December 2016, 30 patients underwent EUS-CDS, including 20 (67 %) with failed biliary cannulation and 10 (33 %) with duodenal stenosis. Technical success was achieved in 28 patients, all of whom also had clinical success. Median total serum bilirubin decreased from 20 mg/dL to 5 mg/dL at 2 weeks post-procedure. Three patients (10 %) had adverse events (bile leak, hemobilia, stent block in one patient each; no stent migration); none of these adverse events was major and all were managed successfully. There were no procedure-related deaths. Five patients died of disease progression in the 3-month period post-procedure, and the 3-month dysfunction-free stent patency rate was 83 %.
Conclusion EUS-CDS with a PCSEMS has a high technical and clinical success. Adverse events were infrequent, minor and could be managed easily.
Endoscopic ultrasound guided needle-based confocal laser endomicroscopy in solid pancreatic masses – a prospective validation study
Authors: Karstensen John , Cârţână Tatiana , Constantinescu Codruţa , Dumitrașcu Silviu , Kovacevic Bojan , Klausen Pia , Hassan Hazem , Klausen Tobias , Bertani Helga , Bhutani Manoop , Săftoiu Adrian , Vilmann Peter 
Published: January 2018

Abstract
Background and study aims Endoscopic ultrasound fine-needle aspiration (EUS-FNA) is a keystone in diagnosing and staging of pancreatic masses. Recently, a microfiber that can pass through a 19-gauge needle has been introduced for confocal laser endomicroscopy (nCLE). The aims of this study were to evaluate the diagnostic value and the reproducibility of nCLE criteria for solid malignant lesions.
Patients and methods This prospective dual-center study included patients with pancreatic masses suspicious of malignancy referred for EUS-FNA. Endomicroscopic imaging was performed under EUS-guidance until organ-specific structures were obtained. Afterwards, standard cytology was obtained and patients were followed for up to 12 months. All nCLE parameters included in former studies were correlated with the final diagnosis (dark lobular structures/normal acinar cells, dark cell aggregates > 40 µm, dilated irregular vessels with fluorescein leakage, fine white fibrous bands, small black cell movements, pseudoglandular structures). Finally, three CLE novices and three CLE experts assessed the unedited movies from all patients.
Results Twenty-eight patients were enrolled in the study. A final diagnosis was obtained in 24 patients (86 %). One patient (3 %) died before a diagnosis was obtained, while 3 were lost to follow-up (11 %). In 18/24 patients (74 %) the diagnosis was malignant. The mean sensitivity, specificity, and accuracy for the nCLE parameters ranged from 19 – 93 %, 0 – 56 %, 26 – 69 %, respectively. The inter-observer values ranged from κ = 0.20 – 0.41 for novices and κ = –0.02 – 0.38 for experts.
Conclusions The diagnostic value of nCLE in solid pancreatic masses is questionable and the inter-observer agreement for both novices and CLE experts appears limited.
Ameliorative Effects of Zataria Multiflora Hydro-Alcoholic extract on Gentamicin Induced Nephrotoxicity in Rats
Authors: Hajihashemi Saeed , Jafarian Tahereh , Ahmadi Mahboubeh , Rahbari Ali , Ghanbari Fatemeh 
Published: January 2018

Abstract
Background Nephrotoxicity is the major side effects of aminoglycoside antibiotics such as gentamicin. The aim of this study was to investigate the therapeutic effects of Z.multiflora (ZM) hydroalcoholic extract on gentamicin-induced nephrotoxicity.
Methods Twenty-eight male Wistar rats categorized into four groups: 1) the control group without injection, 2) the gentamicin treated group (100 mg/kg, i.p) 3) the gentamicin and Z. Multiflora treated group; Z. Multiflora extract(0.8 mg/ml in the drinking water) administered after gentamicin (100 mg/kg, i.p) 4) the normal saline and Z. Multiflora treated group; Z. Multiflora extract (0.8 mg/ml in the drinking water) administered after normal saline injection (2 ml/kg,i.p ).
Results Post-treatment with ZM extract caused a significant reduction in the levels of plasma creatinine and blood urea nitrogen (BUN), absolute and fractional excretion of sodium, malondialdehyed (MDA) level in comparison to gentamicin group. In addition, ZM extract significantly increased creatinine clearance, urine osmolarity, and Renal blood flow (RBF) and the Ferric reducing ability of plasma (FRAP) level which had decreased compared to the control group as a result of treatment with gentamicin.
Conclusion The above result indicated that ZM extract improved renal toxicity of gentamicin via reducing oxidative stress, oxygen-free radicals, and lipid peroxidation.
Risk factors for allograft failure in liver transplant recipients
Authors: Huesing-Kabar Anna , Dohna Christina zu , Heinzow Hauke , Cicinnati Vito , Beckebaum Susanne , Schmidt Martina , Gerth Hans , Pohlen Michele , Wilms Christian , Palmes Daniel , Schmidt Hartmut , Kabar Iyad 
Published: January 2018

Abstract
Background With regard to quality of life and organ shortage, follow-up after liver transplantation (LT) should consider risk factors for allograft failure in order to avoid the need for re-LT and to improve the long-term outcome of recipients. Therefore, the aim of this study was to explore potential risk factors for allograft failure after LT.
Material and methods A total of 489 consecutive LT recipients who received follow-up care at the University Hospital of Muenster were included in this study. Database research was performed, and patient data were retrospectively reviewed. Risk factors related to donor and recipient characteristics potentially leading to allograft failure were statistically investigated using binary logistic regression analysis. Graft failure was determined as graft cirrhosis, need for re-LT because of graft dysfunction, and/or allograft-associated death.
Results The mean age of recipients at the time of LT was 50.3 ± 12.4 years, and 64.0 % were male. The mean age of donors was 48.7 ± 15.5 years. Multivariable statistical analysis revealed male recipient gender (p = 0.04), hepatitis C virus infection (HCV) (p = 0.014), hepatocellular carcinoma (HCC) (p = 0.03), biliary complications after LT (p < 0.001), pretransplant diabetes mellitus (p = 0.03), and/or marked fibrosis in the initial protocol biopsy during follow-up (p = 0.001) to be recipient-related significant and independent risk factors for allograft failure following LT.
Conclusion Male recipients, patients who received LT for HCV or HCC, those with pretransplant diabetes mellitus, and LT recipients with biliary complications are at high risk for allograft failure and thus should be monitored closely.
Rogue waves and large deviations in deep sea
Authors: Dematteis Giovanni , Grafke Tobias , Vanden-Eijnden Eric 
Published: January 2018

Significance
Quantifying the departure from Gaussianity of the wave-height distribution in the seas and thereby estimating the likelihood of appearance of rogue waves is a long-standing problem with important practical implications for boats and naval structures. Here, a procedure is introduced to identify ocean states that are precursors to rogue waves, which could permit their early detection. Our findings indicate that rogue waves obey a large deviation principle—i.e., they are dominated by single realizations—which our method calculates by solving an optimization problem. The method generalizes to estimate the probability of extreme events in other deterministic dynamical systems with random initial data and/or parameters, by using prior information about the nature of their statistics.
Biodegradable Piezoelectric Force Sensor
Authors: Curry Eli J. , Ke Kai , Chorsi Meysam T. , Wrobel Kinga S. , Miller Albert N. , Patel Avi , Kim Insoo , Feng Jianlin , Yue Lixia , Wu Qian , Kuo Chia-Ling , Lo Kevin W.-H. , Laurencin Cato T. , Ilies Horea , Purohit Prashant K. , Nguyen Thanh D. 
Published: January 2018

Significance
Measuring physiological pressures such as lung pressure, brain pressure, eye pressure, etc. is important for monitoring health status, preventing the buildup of dangerous internal forces in impaired organs, and enabling novel approaches of using mechanical stimulation for tissue regeneration. Pressure sensors are often implanted and directly integrated with soft biological systems. Therefore, the devices should be flexible and at the same time biodegradable to avoid invasive removal surgery. Here, we present the study and processing of a biodegradable polymer which can convert mechanical force to electricity, and employ the polymer to develop a biocompatible implanted force sensor. The sensor, relying solely on common medical materials, can monitor important biological forces and eventually self-vanish, causing no harm to the body.
Local policy proposals can bridge Latino and (most) white Americans’ response to immigration
Authors: Huo Yuen J. , Dovidio John F. , Jiménez Tomás R. , Schildkraut Deborah J. 
Published: January 2018

Significance
Subnational immigrant policies (i.e., those instituted at the state level in the United States) are not only key to successful integration, they send a message about who belongs. Our evidence suggests that welcoming state-level immigrant policies lead to greater belonging among foreign-born Latinos, US-born Latinos, and even US-born whites. Only self-identified politically conservative whites showed depressed feelings of belonging when state policies support immigrants. Patterns remained constant across states that vary in their historic reception of immigrants (Arizona and New Mexico). These findings suggest that debates about the polarizing effects of immigration policies by racial group are misplaced. With a majority of whites nationally identifying as either liberal or moderate, welcoming immigration policies have direct and spillover effects that can further national unity.
Kinase-independent function of E-type cyclins in liver cancer
Authors: Geng Yan , Michowski Wojciech , Chick Joel M. , Wang Yaoyu E. , Jecrois M. Emmanuelle , Sweeney Katharine E. , Liu Lijun , Han Richard C. , Ke Nan , Zagozdzon Agnieszka , Sicinska Ewa , Bronson Roderick T. , Gygi Steven P. , Sicinski Piotr 
Published: January 2018

Significance
Amplification of the cyclin E genes and overexpression of cyclin E proteins is very frequent in several human tumor types. In particular, overexpression of E cyclins was implicated in the pathogenesis of liver cancers. According to the current cell division models, E cyclins drive tumor cell proliferation by activating its kinase partner, the cyclin-dependent kinase 2 (CDK2). In this study, we demonstrate that E cyclins are dispensable for adult mouse physiology, but essential for liver cancer progression. Surprisingly, we found that the function of E cyclins in liver tumorigenesis is kinase independent. Our study suggests that agents targeting E cyclins would be efficacious in liver cancer treatment, as they would halt proliferation of tumor cells while sparing normal tissues.
Regulation of the stability of RGF1 receptor by the ubiquitin-specific proteases UBP12/UBP13 is critical for root meristem maintenance
Authors: An Zhichao , Liu Yuliang , Ou Yang , Li Jia , Zhang Baowen , Sun Daye , Sun Yu , Tang Wenqiang 
Published: January 2018

Significance
Reversible ubiquitination regulates cellular protein abundance. The receptor-like kinase (RLK) RGFR1 plays an important role in regulating root meristem development. Upon ligand binding, activated RGFR1 is ubiquitinated and eventually degraded by the 26S proteasome. In this study, we found that the ubiquitin-specific proteases UBP12 and UBP13 are components of the RGFR1 signaling pathway. UBP13 interacts directly with RGFR1 and can counteract the ligand-induced ubiquitination and degradation of RGFR1. Our discovery provides insight into the dynamic regulation of cell-surface RLKs, which may serve to fine-tune the sensitivity of plant cells to extracellular stimuli.
Uncovering the role of the East Asian jet stream and heterogeneities in atmospheric rivers affecting the western United States
Authors: Zhang Wei , Villarini Gabriele 
Published: January 2018

Significance
Atmospheric rivers (ARs) have major socioeconomic repercussions along the US West Coast due to heavy rainfall, flooding, strong winds, and storm surge. However, our understanding of the physical drivers responsible for their interannual variability is still limited, with different climate modes identified as possible mechanisms. Here we find that the Pacific-Japan teleconnections/patterns and the East Asian subtropical jet exhibit the strongest linkage with the total frequency of landfalling ARs affecting the western United States, much stronger than the other potential climate modes previously considered. We also uncover heterogeneities in AR tracks; specifically, not all ARs making landfall along the US West Coast come from a single population, but rather it is possible to stratify them into three main clusters.
Cytocapsular tubes conduct cell translocation
Authors: Yi Tingfang , Wagner Gerhard 
Published: January 2018

Significance
Cell migration in multicellular organisms is crucial for embryonic development, immune responses, organ homeostasis, tissue regeneration, and tumor metastasis. However, mechanisms of cell locomotion in tissues are elusive. Here we report that single mammalian cells generate extracellular and membranous cytocapsular tubes as highways for directed cell transportation. Cytocapsular tubes interconnect and form tubular networks for directed cell transportation in multiple directions. Increased eukaryotic translation initiation factor eIF4E-mediated cap-dependent translation initiation promotes cytocapsular tube development. This study reveals that cytocapsular tubes provide membranous tubes for directed cell translocation.