bluuebunny/crossref_metadata_2025_split huggingface dataset:
Local Communities and Schools Tackling Sustainability and Climate Change
Authors: Flowers Rick , Chodkiewicz Andrew 
Published: February 2017

AbstractLocal communities and their schools remain key sites for actions tackling issues of sustainability and climate change. A government-funded environmental education initiative, the Australian Sustainable Schools Initiative (AuSSI), working together with state based Sustainable Schools Programs (SSP), has the ability to support the development of more effective community and school relationships. We are interested in the possibilities of enabling more authentic and transformative learning experiences in community and school relationships, by developing a more analytical approach to communities and schools working together. Drawing on Uzzell's (1999) framework and a number of recent empirical studies we describe how communities and schools in one Australian State, New South Wales, have been working together for environmental sustainability. We point to how the links between local communities and schools continue to be under-utilised, and suggest ways that these important relationships can be strengthened and extended.
Call for Research – The Consuming Child-in-Context in Unhealthy and Unsustainable Times
Authors: Skouteris Helen , Do Michael , Rutherford Leonie , Cutter-Mackenzie Amy , Edwards Susan 
Published: February 2017

AbstractChildhood obesity is a highly complex issue with serious health and environmental implications. It has been postulated that young children (preschool-aged in particular) are able to internalise positive environmental beliefs. Applying a socioecological theoretical perspective, in this discussion paper we argue that although children may internalise such beliefs, they commonly behave in ways that contradict these beliefs as demonstrated by their consumer choices. The media directly influences these consumer choices and growing evidence suggests that media exposure (particularly commercial television viewing) may be a significant “player” in the prediction of childhood obesity. However, there is still debate as to whether childhood obesity is caused by digital media use per se or whether other factors mediate this relationship. Growing evidence suggests that researchers should examine whether different types of content have conflicting influences on a child's consumer choices and, by extension, obesity. The extent to which young children connect their consumer choices and the sustainability of the produces they consume with their overall health and wellbeing has not previously been researched. To these ends, we call for further research on this socioecological phenomenon among young children, particularly with respect to the influence of digital media use on a child's consumer behaviours.
Empowering Students to Act: Learning About, Through and From the Nature of Action
Authors: Birdsall Sally 
Published: February 2017

AbstractEmpowering students to act in an environmentally responsible manner is being increasingly touted as a central goal of formal environmental education. Acting in a responsible manner requires the development of environmental knowledge as well as positive attitudes and values towards the environment along with other attributes. While some guidance about how to plan and teach environmental education is available in curriculum and policy documents, teachers are often either unfamiliar with such documents and/or unaware of the theories and pedagogy of environmental education (Cutter-Mackenzie & Smith, 2003; Eames, Cowie, & Bolstad, 2008). This paper offers a definition of environmentally responsible behaviour and identifies the role that knowledge could play when environmentally responsible action is taken by students that could be useful for teachers.Three different lenses are used to examine the knowledge developed by 11-12 year old students and their subsequent actions during engagement in an environmental education programme (n=22). The lenses consist of a cluster of types of knowledge developed by Jensen (2002), a framework for analysing understandings of sustainability and the type of actions taken (Jensen & Schnack, 1997; Kollmuss & Agyeman, 2002).The results suggest that these students developed different types of knowledge that informed the actions taken and that their actions can be categorised as action competence. It is also suggested that these types of knowledge need to be taught explicitly. A three part model is then proposed that could assist students to learn about the nature of action, enabling them to work towards potential solutions for complex environmental issues.
Quantifying Desert Prior to the Rightful Condition: Towards a Theoretical Understanding of the Provocation Defence
Authors: Da Silva Michael 
Published: February 2017

The provocation defence, which militates against full legal responsibility for unjustified killings in several common law jurisdictions, has been the subject of considerable controversy during recent decades. Much of the criticism focused on substantive legal issues. This article examines the philosophical bases for the defence in hopes of establishing a theoretical groundwork for future debate on the legal defence. The defence originated on desert bases and continues to be understood on those grounds. This article thus examines it in light of two dominant desert-based theories of punishment originating with Aristotle and Immanuel Kant respectively.Ultimately, the best theory of punishment and the best theory of defence are provided by different approaches. The more plausible and robust Kantian theory of punishment can nonetheless be supplemented by the Aristotelean theory of defence as a continent sociological morality to create a more nuanced account of defence that better explains both excuses in general and the provocation defence in particular. From a substantive legal perspective, this position justifies continued use of the provocation defence in our imperfect legal order, but the partial excuse of provocation will not exist in the ideal legal order. An ideal political order will sufficiently control its citizens’ emotions such that the defence cannot be justified. A partial excuse of provocation is only necessary in the interim.
The Binding Force of Nascent Norms of International Law
Authors: Reeves Anthony R. 
Published: February 2017

Demonstrating that a developing norm is not yet well established in international law is frequently thought to show that states are not bound by the norm as law. More precisely, showing that a purported international legal norm has only limited support from well-established international legal sources is normally seen as sufficient to rebut an obligation on the part of subjects to comply with the norm in virtue of its legal status. I contend that this view is mistaken. Nascent norms of international law (e.g., crystallizing norms of customary law) can be binding in much the same way as better-established doctrine. This point becomes perspicuous, I argue, once we get a clear sense of the plausible options for grounding the moral authority of international law generally.This result is interesting in its own right, but it also reveals two other features of the character of state responsibility under international law. First, the distinction between legislation and compliance is less pronounced compared to domestic law. Consequently, the virtues of good governance will frequently be pertinent to determining the content of states’ obligations under international law. Second, normally more powerful and influential agents will be more strongly bound by international law than other subjects. This is an attractive result, addressing a concern that motivates many international lawyers to view international law as absolutely binding. An absolutist view international legal authority is unnecessary for showing that the most powerful and dangerous states are strongly bound by the terms of much existing law.
Remembering the West End: social science, mental health and the American urban environment, 1939–1968
Authors: RAMSDEN EDMUND , SMITH MATTHEW 
Published: February 2017

ABSTRACT:Analysing the urban renewal of Boston's West End during the 1950s, we examine how psychiatrists, social scientists and urban planners understood the relationship between the urban environment and mental health. For psychiatrist Erich Lindemann, the West End offered a unique opportunity to study how acute stress and loss affected populations, thus contributing to social psychiatry, which sought to prevent mental illness by addressing factors in the social and physical environment. While Lindemann's project provided a sophisticated response to the often simplistic arguments about the cities and mental health, it also highlighted the challenges of applying social psychiatric theory in practice.
Impaired hypothalamic-pituitary-testicular axis activity, spermatogenesis, and sperm function promote infertility in males with lead poisoning
Authors: Gandhi Jason , Hernandez Rafael J. , Chen Andrew , Smith Noel L. , Sheynkin Yefim R. , Joshi Gargi , Khan Sardar Ali 
Published: February 2017

SummaryLead poisoning is a stealthy threat to human physiological systems as chronic exposure can remain asymptomatic for long periods of time before symptoms manifest. We presently review the biophysical mechanisms of lead poisoning that contribute to male infertility. Environmental and occupational exposure of lead may adversely affect the hypothalamic−pituitary−testicular axis, impairing the induction of spermatogenesis. Dysfunction at the reproductive axis, namely testosterone suppression, is most susceptible and irreversible during pubertal development. Lead poisoning also appears to directly impair the process of spermatogenesis itself as well as sperm function. Spermatogenesis issues may manifest as low sperm count and stem from reproductive axis dysfunction or testicular degeneration. Generation of excessive reactive oxygen species due to lead-associated oxidative stress can potentially affect sperm viability, motility, DNA fragmentation, membrane lipid peroxidation, capacitation, hyperactivation, acrosome reaction, and chemotaxis for sperm-oocyte fusion, all of which can contribute to deter fertilization. Reproductive toxicity has been tested through cross-sectional analysis studies in humans as well asin vivoandin vitrostudies in animals.
Associations between Psychosocial Problems and Personality Disorders among Egyptian Adolescents
Authors: Elbheiry Abd-Elraqeep , Emam Mahmoud 
Published: February 2017

AbstractThe study investigated the relationship between psychosocial problems and personality disorders among a sample of 817 Egyptian adolescents (408 males and 409 females). Using 15 subscales from the Adolescent Psychopathology Scale (APS-long form) we assessed prevalence rates of a number of internalizing and externalizing psychosocial disorders. Additionally, we investigated whether there are gender differences in psychopathology among Egyptian adolescents and to what extent can psychosocial problems predict specific personality disorders. Stepwise multiple regression analyses showed that the participants experienced higher levels of PD, AV, and BD. Gender differences were found in certain personality disorders as well as in externalizing and internalizing psychosocial problems. A number of externalizing and internalizing psychosocial problems were highly predictive of specific personality disorders.
Zung Scale Factor Invariance in Male Coronary Patients and Healthy People
Authors: Pérez Antonio del Pino , Fernández Ignacio Ibáñez , Ojeda Francisco Bosa , González Ruth Dorta , Gaos Meizoso María Teresa 
Published: February 2017

AbstractThe objective of this study was, firstly, to determine the factor structure and factor invariance of the Zung Self-Rating Depression Scale (ZSDS) and, secondly, to justify its use in coronary patients (CPs) and healthy people (HP). Two comparable samples of males were studied: 217 CPs and 191 HP. Exploratory and confirmatory factor analyses (EFA and CFA) for ordinal data were carried out with Mplus. Two models obtained from all participants in this study and another two, the model of Shafer (2006) from a meta-analysis and that of Barefoot et al. (2000) with CPs, were analyzed in CFA. A two-factor structure was supported by EFA in both samples, but none of the models showed adequate goodness-of-fit for the CPs and the HP in CFA. Only the two and three-factor models obtained from the combined sample of CPs and HP showed adequate goodness-of-fit for HP. The ZSDS showed good reliability, replicated the prevalence of depressive symptoms found in other studies and was able to distinguish between CPs and HP. We conclude that the best fit is obtained from the two-factor solution in HP, that the factor structure of the ZSDS is not invariant and is linked to positively and negatively worded items.
Romantic Attachment in Chilean Adults: Development of a Short-form Version of the Experiences in Close Relationships
Authors: Spencer Rosario , Alonso-Arbiol Itziar , Fresno Andrés 
Published: February 2017

AbstractThough the study of romantic attachment has expanded into all areas of psychology, it remains the case that there is no valid, reliable test available to measure it in Latin America. The present research objective was to adapt a Chilean version of the Experiences in Close Relationships (ECR; Brennan, Clark, & Shaver 1998) questionnaire, developing a short-form version, and to determine its factor structure in two samples of Chilean adults of different ages. A pool of 25 items was chosen to capture the two dimensions (Anxiety and Avoidance), which were obtained through principal components analysis in a sample of 477 adults. Subsequently, the short-form ECR’s two-dimensional structure was confirmed using confirmatory factor analysis in a new sample (N = 296). All sub-dimensions’ internal consistencies were found to be satisfactory. Evidence for the test’s concurrent validity with the variables age, gender, and socioeconomic status was also obtained. The dimensions of romantic attachment showed no differences according to age or gender. However, participants of high socioeconomic status exhibited lower levels of anxious attachment than those with low socioeconomic status. It was concluded that the Chilean short-form version of the ECR has good psychometric properties and is a suitable assessment of adult attachment.
Adaptation of the Questionnaire of Hahn, Cella, Bode, and Hanrahan in Spanish Patients Affected by Asbestos Poisoning
Authors: Clemente Miguel , Reig-Botella Adela 
Published: February 2017

AbstractThe purpose of this study was to assess whether or not the questionnaire developed by Hahn, Cella, Bode, and Hanharan (2010) for use with cancer patients accurately measures the social well-being of individuals suffering from chronic illnesses associated with asbestos poisoning. One hundred ten male patients with asbestos poisoning were age-matched in blocks to a comparison group of 70 “healthy” controls, all of whom were current or retired employees of the largest naval company in Spain. The results indicate very high reliability of the Hahn et al. (2010) test to assess social well-being in these chronically ill patients, and a high concurrent validity of the measured outcomes with regard to results of the SCL-90 Derogatis questionnaire, especially on the social well-being dimensions of negative emotional support, negative social companionship, and satisfaction. Limitations of the study and possible future directions are discussed.
Gender Differences in Emotions, Forgiveness and Tolerance in Relation to Political Violence
Authors: Conejero Susana , Etxebarria Itziar , Montero Ignacio 
Published: February 2017

AbstractThis study, which forms part of a broader research project, analyzes gender differences in: the intensity of diverse emotions, the justification of violence, attitudes towards the terrorist group ETA, forgiveness and tolerance. Participants comprised 728 people (45.5% men and 54.5% women) resident in either Basque Country or Navarra (Spain), representative of all national identities and political ideologies existing in this context. An ad hoc questionnaire was designed and administered between November 2005 and February 2006, a short time before ETA declared a ceasefire. Women reported more intensity in fear for political reasons and scored higher in two of the six measures of empathy included in the study (empathy with prisoners and empathy with those who suffer and think like oneself). Men scored higher in positive emotionality, indifference and Schadenfreude. Women perceived apology and forgiveness as more necessary elements for achieving peace than men. These results suggest that it may be beneficial for women to play a more prominent role in relation to the resolution of intergroup conflicts such as the one existing in the Basque Country.
Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors
Authors: Schütte Moritz , Risch Thomas , Abdavi-Azar Nilofar , Boehnke Karsten , Schumacher Dirk , Keil Marlen , Yildiriman Reha , Jandrasits Christine , Borodina Tatiana , Amstislavskiy Vyacheslav , Worth Catherine L. , Schweiger Caroline , Liebs Sandra , Lange Martin , Warnatz Hans- Jörg , Butcher Lee M. , Barrett James E. , Sultan Marc , Wierling Christoph , Golob-Schwarzl Nicole , Lax Sigurd , Uranitsch Stefan , Becker Michael , Welte Yvonne , Regan Joseph Lewis , Silvestrov Maxine , Kehler Inge , Fusi Alberto , Kessler Thomas , Herwig Ralf , Landegren Ulf , Wienke Dirk , Nilsson Mats , Velasco Juan A. , Garin-Chesa Pilar , Reinhard Christoph , Beck Stephan , Schäfer Reinhold , Regenbrecht Christian R. A. , Henderson David , Lange Bodo , Haybaeck Johannes , Keilholz Ulrich , Hoffmann Jens , Lehrach Hans , Yaspo Marie-Laure 
Published: February 2017

AbstractColorectal carcinoma represents a heterogeneous entity, with only a fraction of the tumours responding to available therapies, requiring a better molecular understanding of the disease in precision oncology. To address this challenge, the OncoTrack consortium recruited 106 CRC patients (stages I–IV) and developed a pre-clinical platform generating a compendium of drug sensitivity data totalling >4,000 assays testing 16 clinical drugs on patient-derived in vivo and in vitro models. This large biobank of 106 tumours, 35 organoids and 59 xenografts, with extensive omics data comparing donor tumours and derived models provides a resource for advancing our understanding of CRC. Models recapitulate many of the genetic and transcriptomic features of the donors, but defined less complex molecular sub-groups because of the loss of human stroma. Linking molecular profiles with drug sensitivity patterns identifies novel biomarkers, including a signature outperforming RAS/RAF mutations in predicting sensitivity to the EGFR inhibitor cetuximab.
Optogenetic control of cellular forces and mechanotransduction
Authors: Valon Léo , Marín-Llauradó Ariadna , Wyatt Thomas , Charras Guillaume , Trepat Xavier 
Published: February 2017

AbstractContractile forces are the end effectors of cell migration, division, morphogenesis, wound healing and cancer invasion. Here we report optogenetic tools to upregulate and downregulate such forces with high spatiotemporal accuracy. The technology relies on controlling the subcellular activation of RhoA using the CRY2/CIBN light-gated dimerizer system. We fused the catalytic domain (DHPH domain) of the RhoA activator ARHGEF11 to CRY2-mCherry (optoGEF-RhoA) and engineered its binding partner CIBN to bind either to the plasma membrane or to the mitochondrial membrane. Translocation of optoGEF-RhoA to the plasma membrane causes a rapid and local increase in cellular traction, intercellular tension and tissue compaction. By contrast, translocation of optoGEF-RhoA to mitochondria results in opposite changes in these physical properties. Cellular changes in contractility are paralleled by modifications in the nuclear localization of the transcriptional regulator YAP, thus showing the ability of our approach to control mechanotransductory signalling pathways in time and space.
Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression
Authors: Xu Wen Wen , Li Bin , Guan Xin Yuan , Chung Sookja K. , Wang Yang , Yip Yim Ling , Law Simon Y. K. , Chan Kin Tak , Lee Nikki P. Y. , Chan Kwok Wah , Xu Li Yan , Li En Min , Tsao Sai Wah , He Qing-Yu , Cheung Annie L. M. 
Published: February 2017

AbstractLocal interactions between cancer cells and stroma can produce systemic effects on distant organs to govern cancer progression. Here we show that IGF2 secreted by inhibitor of differentiation (Id1)-overexpressing oesophageal cancer cells instigates VEGFR1-positive bone marrow cells in the tumour macroenvironment to form pre-metastatic niches at distant sites by increasing VEGF secretion from cancer-associated fibroblasts. Cancer cells are then attracted to the metastatic site via the CXCL5/CXCR2 axis. Bone marrow cells transplanted from nude mice bearing Id1-overexpressing oesophageal tumours enhance tumour growth and metastasis in recipient mice, whereas systemic administration of VEGFR1 antibody abrogates these effects. Mechanistically, IGF2 regulates VEGF in fibroblasts via miR-29c in a p53-dependent manner. Analysis of patient serum samples showed that concurrent elevation of IGF2 and VEGF levels may serve as a prognostic biomarker for oesophageal cancer. These findings suggest that the Id1/IGF2/VEGF/VEGFR1 cascade plays a critical role in tumour-driven pathophysiological processes underlying cancer progression.
Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy
Authors: Crawford Devon C. , Ramirez Denise M. O. , Trauterman Brent , Monteggia Lisa M. , Kavalali Ege T. 
Published: February 2017

AbstractRecent studies suggest that stimulus-evoked and spontaneous neurotransmitter release processes are mechanistically distinct. Here we targeted the non-canonical synaptic vesicle SNAREs Vps10p-tail-interactor-1a (vti1a) and vesicle-associated membrane protein 7 (VAMP7) to specifically inhibit spontaneous release events and probe whether these events signal independently of evoked release to the postsynaptic neuron. We found that loss of vti1a and VAMP7 impairs spontaneous high-frequency glutamate release and augments unitary event amplitudes by reducing postsynaptic eukaryotic elongation factor 2 kinase (eEF2K) activity subsequent to the reduction in N-methyl-D-aspartate receptor (NMDAR) activity. Presynaptic, but not postsynaptic, loss of vti1a and VAMP7 occludes NMDAR antagonist-induced synaptic potentiation in an intact circuit, confirming the role of these vesicular SNAREs in setting synaptic strength. Collectively, these results demonstrate that spontaneous neurotransmission signals independently of stimulus-evoked release and highlight its role as a key regulator of postsynaptic efficacy.
Genomic RNA folding mediates assembly of human parechovirus
Authors: Shakeel Shabih , Dykeman Eric C. , White Simon J. , Ora Ari , Cockburn Joseph J.B. , Butcher Sarah J. , Stockley Peter G. , Twarock Reidun 
Published: February 2017

AbstractAssembly of the major viral pathogens of the Picornaviridae family is poorly understood. Human parechovirus 1 is an example of such viruses that contains 60 short regions of ordered RNA density making identical contacts with the protein shell. We show here via a combination of RNA-based systematic evolution of ligands by exponential enrichment, bioinformatics analysis and reverse genetics that these RNA segments are bound to the coat proteins in a sequence-specific manner. Disruption of either the RNA coat protein recognition motif or its contact amino acid residues is deleterious for viral assembly. The data are consistent with RNA packaging signals playing essential roles in virion assembly. Their binding sites on the coat proteins are evolutionarily conserved across the Parechovirus genus, suggesting that they represent potential broad-spectrum anti-viral targets.