bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH HARGA, KUALITAS PELAYANAN, DAN PERSONAL SELLING TERHADAP KEPUASAN PELANGGAN TOKO BESI DAN KACA “SANTA” YOGYAKARTA
Authors: Ardiyanto Laurentius Dian , Pradiani Theresia , Fatthorrahman Fatthorrahman 
Published: September 2024

Kepuasan pelanggan merupakan elemen kunci keberhasilan bisnis, terutama pada bisnis yang persaingannya sangat ketat seperti ritel bahan bangunan. Pengusaha perlu mengupayakan strategi-strategi kreatif untuk mempertahankan kepuasan pelanggan, untuk itu perlu pemahaman faktor-faktor yang mempengaruhi kepuasan pelanggan. Penelitian ini bertujuan untuk mengetahui pengaruh harga, kualitas pelayanan dan personal selling terhadap kepuasan pelanggan Toko Besi dan Kaca “Santa” Yogyakarta. Penelitian ini merupakan penelitian kuantitatif dengan teknik pengambilan data menggunakan kuesioner. Responden sebanyak 63 orang adalah pelanggan yang pernah berbelanja lebih dari 3 kali selama 2 tahun terakhir. Teknik analisa menggunakan regresi linier berganda; pengujian hipotesis menggunakan uji t dan uji F. Berdasarkan hasil uji t diketahui bahwa (1) harga tidak berpengaruh pada kepuasan pelanggan, (2) kualitas pelayanan tidak berpengaruh terhadap kepuasan pelanggan, sedangkan (3) personal selling berpengaruh terhadap kepuasan pelanggan. Pengujian ketiga variabel secara simultan dengan uji F menunjukkan ketiga variabel berpengaruh terhadap kepuasan pelanggan.
PENGARUH LIKUIDITAS, PROFITABILITAS DAN SOLVABILITAS TERHADAP HARGA SAHAM PADA PERUSAHAAN PERBANKAN
Authors: Tindaon Aldy Yefta 
Published: September 2024

This research aims to analyze the influence of liquidity, profitability and solvency on share prices in banking companies. The sample for this research consists of 33 companies listed on the Indonesial Stock Exchange (BEI) to submit their financial reports for the 2021-2023 period. The data used in this research is secondary datal and the sample selection used the purposive sampling method. The analytical tool used is multiple linear regression analysis. The results of hypothesis testing show that liquidity and solvency have no effect on stock prices, while profitability has effect on stock prices.
SERTIFIKASI HALAL DAN PENGARUHNYA TERHADAP KINERJA UMKM
Authors: Fitri Raisa 
Published: September 2024

Tujuan dari penelitian ini adalah untuk menjelaskan peran mediasi kinerja inovasi dan kinerja pasar terhadap pengaruh sertifikasi halal produk makanan terhadap kinerja UMKM di Kabupaten Malang. Banyak pelaku UMKM belum paham akan pentingnya status kehalalan untuk produk yang dihasilkan, hal tersebut merupakan peluang yang harus dimanfaatkan oleh pelaku UMKM di Kabupaten Malang. Oleh karena itu, dukungan dari pemerintah diharapkan dapat meningkatkan kesadaran UMKM akan sertifikasi halal yang nantinya akan meningkatkan kinerja UMKM. Regulasi mengenai kewajiban halal telah diatur dalam Undang-undang Nomor 33 Tahun 2014 mengenai Jaminan Produk Halal, termasuk kategori makan dan minuman. Metode kuantitatif dan pengujian hipotesis digunakan dalam penelitian ini. Berdasarkan kriteria pengambilan sampel maka jumlah data yang terkumpul sebanyak 188 UMKM di Kabuaten Malang dengan kategori produk makanan yang sudah memiliki sertifikasi halal, penyebaran data menggunakan kuesioner online dengan pengukuran skala likert (1-5). Setalah data terkumpul, teknis analisisnya menggunakan SEM-PLS. Hasil penelitian menjelaskan bahwa sertifikasi halal berpengaruh secara signifikan terhadap kinerja keuangan dan kinerja inovasi. Selanjutnya, temuan lain menjelaskan adanya pengaruh sertifikasi halal terhadap kinerja pasar. Temuan lain menjelaskan bahwa ada pengaruh positif antara kinerja inovasi terhadap kinerja keuangan. Kemudian, kinerja inovasi dan kinerja pasar mampu memediasi pengaruh antara sertifikasi halal terhadap kinerja keuangan
Early Prevention Of DPN (Diabetic Peripheral Neuropathy) In Patients With Diabetes Mellitus Type 2 In Mangunjaya Village Subdistrict Tambun Selatan Bekasi
Authors: Sartika Mila 
Published: September 2024

..Diabetes Melitus (DM) merupakan sekelompok kelainan heterogen yang ditandai oleh kenaikan kadar glukosa dalam darah atau hiperglikemia. Hiperglikemia terjadi karena kemampuan tubuh untuk bereaksi terhadap insulin menurun atau pankreas menghentikan produksi insulin. Kondisi tersebut dapat menyebabkan penderita diabetes perlahan-lahan beresiko mengalami terjadinya neuropathy. Tujuan umum yang merupakan solusi dari pencegahan dini DPN adalah untuk meminimalisir terjadinya DPN pada Diabetisi sehingga dapat meningkatkan kualitas kesehatan yang lebih optimal bagi Diabetisi khususnya di wilayah RW. 12 Desa Mangunjaya Kecamatan Tambun Selatan Kabupaten Bekasi Tahun 2022. Hasil pelaksanaan PKM pada tahap pertama hasil observasi pelaksanaan exercise tangan dan kaki pada diabetisi di desa Mangunjaya Rw. 12 Kecamatan Tamun Selatan diperoleh hasil bahwa dari 89 diabetisi 100% aktif mengikuti latihan exercise tangan dan kaki. Pada tahap ke dua diperoleh hasil Creening Neuropati Michigan (MSI) dari 89 diabetisi terdapat 59 (66,3%) dibetisi terindikasi DPN. Pencegahan dini merupakan salah satu solusi yang paling tepat dalam penanganan resiko DPN pada kasus DM tipe II. Dalam pelaksanaan PKM ini yang akan dilakukan oleh penulis adalah dengan mengajarkan exercise (latihan) gerak tangan dan kaki pada Diabetisi sebagai upaya pencegahan dini, sehingga mampu meminimalisir terjadinya DPN dan Diabetisi mampu meningkatkan kualitas kesehatan yang optimal. Exercise tangan dan kaki ini dapat dilakukan seminggu 3 kali dengan durasi waktu kurang lebih 30 menit
ANALISIS MANAJEMEN RISIKO PADA PERCETAKAN CV. ARPRO178 DENGAN METODE ISO 31000
Authors: Jannah Nur Faisatul , Praningtyas Elisabeth Ria Viana 
Published: September 2024

Usaha percetakan terus tumbuh sejalan dengan perubahan dan variasi kebutuhan pasar. Namun, sebagaimana halnya dalam industri lain, perusahaan percetakan juga dihadapkan pada berbagai risiko yang kompleks dan bervariasi. Tujuan dari penelitian ini adalah untuk mengidentifikasi, menganalisis dan mengelola risiko, serta menilai tingkat risiko pada tahapan operasional pada Percetakan CV. ARPRO178 di Kota Probolinggo. Penelitian ini menggunakan metode kualitatif, yang menguraikan peran Enterprise Risk Management dalam mengelola risiko di Percetakan CV. ARPRO178 Kota Probolinggo dengan menerapkan metode ISO 31000:2018. Dari hasil penelitian terdapat 13 kemungkinan risiko yang terjadi, diantaranya adalah kualitas bahan baku buruk, keterlambatan pasokan bahan baku, gangguan teknologi yang mengakibatkan hilangnya data, kerusakan mesin dan alat cetak, pemadaman listrik konslet dan gangguan signal wifi, pencurian inventory oleh karyawan, risiko kecelakaan kerja, risiko kehilangan pelanggan akibat digitalisasi, keterlambatan pengiriman ke customer, kualitas warna (pudar) pada produk cetak, kesalahan dalam penulisan huruf, ukuran kurang pas pada produk cetak, bahan baku terbuang saat kesalahan proses cetak.
Determination of the internal loads experienced by proximal phalanx fracture fixations during rehabilitation exercises
Authors: Schwarzenberg Peter , Colding-Rasmussen Thomas , Hutchinson Daniel J. , San Jacinto Garcia Jorge , Granskog Viktor , Mørk Petersen Michael , Pastor Tatjana , Weis Tine , Malkoch Michael , Nai En Tierp-Wong Christian , Varga Peter 
Published: September 2024

Phalangeal fractures are common, particularly in younger patients, leading to a large economic burden due to higher incident rates among patients of working age. In traumatic cases where the fracture may be unstable, plate fixation has grown in popularity due to its greater construct rigidity. However, these metal plates have increased reoperation rates due to inflammation of the surrounding soft tissue. To overcome these challenges, a novel osteosynthesis platform, AdhFix, has been developed. This method uses a light-curable polymer that can be shaped in situ around traditional metal screws to create a plate-like structure that has been shown to not induce soft tissue adhesions. However, to effectively evaluate any novel osteosynthesis device, the biomechanical environment must first be understood. In this study, the internal loads in a phalangeal plate osteosynthesis were measured under simulated rehabilitation exercises. In a human hand cadaver study, a plastic plate with known biomechanical properties was used to fix a 3 mm osteotomy and each finger was fully flexed to mimic traditional rehabilitation exercises. The displacements of the bone fragments were tracked with a stereographic camera system and coupled with specimen specific finite element (FE) models to calculate the internal loads in the osteosynthesis. Following this, AdhFix patches were created and monotonically tested under similar conditions to determine survival of the novel technique. The internal bending moment in the osteosynthesis was 6.78 ± 1.62 Nmm and none of the AdhFix patches failed under the monotonic rehabilitation exercises. This study demonstrates a method to calculate the internal loads on an osteosynthesis device during non-load bearing exercises and that the novel AdhFix solution did not fail under traditional rehabilitation protocols in this controlled setting. Further studies are required prior to clinical application.
Changes in nonfunctional adrenal incidentaloma after COVID-19 infection and a model for predicting benign and malignant adrenal incidentaloma
Authors: Chen Danlei , Zeng Sheng , Liu Qian 
Published: September 2024

AimsTo compare nonfunctional adrenal incidentalomas (NFAI) in individuals with and without a history of COVID-19 infection, while also establishing predictive models for distinguishing between benign and malignant adrenal incidentalomas (AI).MethodsA retrospective collection of data from patients with AI who underwent surgery and were verified in our hospital between April 2022 and June 2023 was conducted. A total of 121 patients were included in the study. Demographic information, tumor characteristics, functional indicators, and complications were compared among the patients. Statistical analyses utilized the t-test for continuous variables and Pearson chi-square test or Fisher’s exact test for categorical variables.ResultsPatients with COVID-19 exhibited a higher prevalence of obesity (84.2% vs. 63.3%, P=0.048) and elevated direct bilirubin (DBIL) levels (44.1% vs. 19.2%, P=0.043) compared to those without COVID-19. Moreover, patients with Malignant AI, in contrast to Benign AI, showed higher normal total protein (TP) levels (28.8% vs. 57.1%, P=0.016) and larger tumor sizes (20 vs. 32.5mm, P=0.009). Univariate analysis identified low TP (OR=0.303, 95% CI=0.111-0.825, P=0.020) and tumor size (OR=1.045, 95% CI=1.011-1.080, P=0.009) as potential risk factors for multivariate analysis. A predictive model comprising clinical risk factors (tumor size and low TP) demonstrated an AUC of 0.754 (95% CI, 0.603-0.904) with a sensitivity of 0.75 and specificity of 0.775. The calibration curve revealed a bias-corrected AUC of 0.77.ConclusionNo discernible differences in the clinical manifestations of adrenal incidentalomas were observed between cases with and without a history of COVID-19 infection. However, AI with larger tumor diameters and lower than normal levels of total protein exhibited a more pronounced malignant potential.
Efficacy and safety of denosumab and teriparatide versus oral bisphosphonates to treat postmenopausal osteoporosis: a systematic review and meta-analysis
Authors: Yang Jia , Guo Xiaobo , Cui Zhongning , Guo Huikang , Dong Jia-Nan 
Published: September 2024

Study DesignA systematic review and Meta-analysisObjectiveTo compare the efficacy and safety of denosumab and teriparatide versus oral bisphosphonates to treat postmenopausal osteoporosis.Summary of Background DataWhile bisphosphonates have historically been the cornerstone of pharmacological management for bone protection in patients, emerging evidence suggests that teriparatide and denosumab warrant further investigation as potential first-line treatments. The optimal choice among denosumab, teriparatide, and oral bisphosphonates for the treatment of postmenopausal osteoporosis remains a subject of ongoing debate and controversy within the scientific community.MethodsThis systematic review adhered meticulously to the rigorous standards outlined by the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines as well as the Cochrane Collaboration recommendations. Additionally, it employed the AMSTAR (Assessing the methodological quality of systematic reviews) criteria to ensure methodological robustness and enhance the credibility of the findings. A systematic electronic search was conducted across Web of Science, PubMed, and the Cochrane Library databases from their inception dates up to February 2024.ResultsIn this meta-analysis of studies, our findings suggest that compared to bisphosphonates, both teriparatide and denosumab demonstrated notable increases in percentage changes in lumbar spine bone mineral density (BMD) among postmenopausal osteoporosis patients. Furthermore, denosumab exhibited superiority over teriparatide and oral bisphosphonates in enhancing percentage changes in both femoral neck and total hip BMD, indicating its potential as a more efficacious option. Regarding safety outcomes, no significant differences were observed in the incidence of serious adverse events among patients treated with teriparatide, denosumab, and bisphosphonates. However, teriparatide showed superiority over oral bisphosphonates in terms of a lower risk of general adverse events, suggesting a favorable safety profile.ConclusionIn conclusion, our study suggests that teriparatide and denosumab demonstrate comparable or potentially superior efficacy and safety profiles compared to oral bisphosphonates for the treatment of postmenopausal osteoporosis.Systematic Review RegistrationPROSPERO, identifier CRD42024508382.
Lipids, lipid-lowering drugs and lateral epicondylitis of the humerus: a drug-targeted Mendelian randomization study
Authors: Liu Meng-Meng , Chen Xiang , Bao Xiao-Hang , Huang Bao-Hua 
Published: September 2024

BackgroundClinical observations indicate that blood lipids may be risk factors for lateral epicondylitis (LE) of the humerus, and lipid-lowering drugs are also used for the prevention and treatment of tendon diseases, but these lack high-quality clinical trial evidence and remain inconclusive. Mendelian randomization (MR) analyses can overcome biases in traditional observational studies and offer more accurate inference of causal relationships. Therefore, we employed this approach to investigate whether blood lipids are risk factors for LE and if lipid-lowering drugs can prevent it.MethodsGenetic variations associated with lipid traits, including low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC), were obtained from the UK Biobank and the Global Lipids Genetics Consortium (GLGC). Data on genetic variation in LE were sourced from FinnGen, including 24,061 patients and 275,212 controls. Subsequently, MR analyses were conducted to assess the potential correlation between lipid traits and LE. Additionally, drug-target Mendelian randomization analyses were performed on 10 drug targets relevant to LE. For those drug targets that yielded significant results, further analysis was conducted using colocalization techniques.ResultsNo correlation was found between three blood lipid traits and LE. Lipoprotein lipase (LPL) enhancement is significantly associated with a decreased risk of LE (OR = 0.76, [95% CI, 0.65–0.90], p = 0.001). The expression of LPL in the blood is associated with LE and shares a single causal variant (12.07%), greatly exceeding the probability of different causal variations (1.93%), with a colocalization probability of 86.2%.ConclusionThe three lipid traits are not risk factors for lateral epicondylitis. LPL is a potential drug target for the prevention and treatment of LE.
Single molecule measurements of microRNAs in the serum of patients with pulmonary tuberculosis
Authors: Wu Zhuhua , Tan Qiuchan , Jia Xiaojuan , Wu Huizhong , Liang Jing , Wen Wenpei , Wang Xuezhi , Zhang Chenchen , Zhao Yuchuan , Chen Yuhui , Luo Tingrong , Liu Wenjun , Chen Xunxun 
Published: September 2024

BackgroundmicroRNAs (miRNAs) were recognized as a promising source of diagnostic biomarker. Herein, we aim to evaluate the performance of an ultrasensitive method for detecting serum miRNAs using single molecule arrays (Simoa).MethodsIn this study, candidate miRNAs were trained and tested by RT-qPCR in a cohort of PTB patients. Besides that, ultrasensitive serum miRNA detection were developed using the Single Molecule Array (Simoa) platform. In this ultra-sensitive sandwich assay, two target-specific LNA-modified oligonucleotide probes can be simply designed to be complementary to the half-sequence of the target miRNA respectively. We characterized its analytical performance and measured miRNAs in the serum of patients with pulmonary tuberculosis and healthy individuals.ResultsWe identified a five signature including three upregulated (miR-101, miR-196b, miR-29a) and two downregulated (miR-320b, miR-99b) miRNAs for distinguishing PTB patients from HCs, and validated in our 104 PTB patients. On the basis of Simoa technology, we developed a novel, fully automated digital analyser, which can be used to directly detect miRNAs in serum samples without pre-amplification. We successfully detected miRNAs at femtomolar concentrations (with limits of detection [LODs] ranging from 0.449 to 1.889 fM). Simoa-determined serum miR-29a and miR-99b concentrations in patients with PTB ((median 6.06 fM [range 0.00–75.22]), (median 2.53 fM [range 0.00–24.95]), respectively) were significantly higher than those in HCs ((median 2.42 fM [range 0.00–28.64]) (P &lt; 0.05), (median 0.54 fM [range 0.00–9.12] (P &lt; 0.0001), respectively). Serum levels of miR-320b were significantly reduced in patients with PTB (median 2.11 fM [range 0.00–39.30]) compared with those in the HCs (median 4.76 fM [range 0.00–25.10]) (P &lt; 0.001). A combination of three miRNAs (miR-29a, miR-99b, and miR-320b) exhibited a good capacity to distinguish PTB from HCs, with an area under the curve (AUC) of 0.818 (sensitivity: 83.9%; specificity: 79.7%).ConclusionsThis study benchmarks the role of Simoa as a promising tool for monitoring miRNAs in serum and offers considerable potential as a non-invasive platform for the early diagnosis of PTB.
The causal association between gut microbiota and postpartum depression: a two-sample Mendelian randomization study
Authors: Jin Wenjun , Li Bo , Wang Lijun , Zhu Lin , Chai Songhao , Hou Rui 
Published: September 2024

BackgroundAn escalating body of clinical trials and observational studies hints at a plausible link between gut flora and postpartum depression (PPD). The definitive causal dynamics between these two entities remain shrouded in ambiguity. Therefore, in this study, we employed the two-sample Mendelian randomization approach to ascertain the causal link between gut microbiota and PPD.MethodsSummary-level GWAS data related to the human gut microbiota were obtained from the international consortium MiBioGen and the Dutch Microbiome Project (species). For PPD, GWAS data were derived from the FinnGen biobank, consisting 57,604 cases and 596,601 controls. The inverse variance weighted method (IVW) as the cornerstone of our analytical approach. Subsequent to this, a comprehensive suite of tests for pleiotropy and heterogeneity were conducted to ensure the reliability and robustness of our findings.ResultsWe identified 12 bacterial taxa associated with the risk of PPD. Veillonellaceae, Ruminococcaceae UCG 011, Bifidobacterium adolescentis, Paraprevotella clara, Clostridium leptum, Eubacterium siraeum, Coprococcus catus exhibited an inversely associated with the risk of PPD. Alphaproteobacteria, Roseburia, FamilyXIIIAD3011group, Alistipes onderdonkii, Bilophila wadsworthia showed a positive correlation with the risk of PPD.LimitationsThe GWAS data derived from the MiBioGen consortium, DMP, and FinnGen consortium, may introduce selection bias. Moreover, the data primarily originates from European populations, hence extrapolating these results to diverse populations should be approached with caution. The etiological factors behind PPD remain enigmatic, alluding to the existence of potential undisclosed confounders.ConclusionBased on this MR analysis, we found a causal relationship between certain gut microbial communities and PPD. Future clinical studies can further explore the treatment of PPD through the combined use of microorganisms. This not only offers insights into the pathogenesis of PPD but also lays the foundation for utilizing gut microbiota as biotherapeutics in treating neurological disorders.
Molecular dynamics simulation of the brain-isolated single-domain antibody/nanobody from camels through in vivo phage display screening
Authors: Hasannejad-Asl Behnam , Hashemzadeh Hassan , Pooresmaeil Farkhondeh , Dabiri Mehran , Pooresmaeil Mohammad-Reza , Ahmadvand Davoud , Hosseini Arshad 
Published: September 2024

IntroductionDuring the last decade, there has been a significant rise in the use of therapeutic antibodies or passive immunotherapy for treating various conditions like inflammation and cancer. However, these proteins face challenges reaching the brain and often require specialized delivery methods such as single-domain antibodies (sdAbs). Traditional antibodies struggle to efficiently cross the blood-brain barrier (BBB), hindering their effectiveness. Receptor-mediated transcytosis (RMT) offers a promising pathway for transporting large molecules essential for brain function and treatment across the BBB.MethodsSdAbs and peptide ligands with an affinity for RMT receptors are commonly employed to enhance the transport of biotherapeutics compounds across the BBB. This research used a sdAbs phage-displayed library from 13 camelus dromedarius samples to identify sdABs that specifically bind to and are internalized by human BBB endothelial cells (ECs) through in vivo panning.Results and discussionOne sdAb, defined as FB24, was isolated, sequenced, translated into an open reading frame (ORF), and subjected to three-dimensional (3D) modeling. Molecular docking and molecular dynamics simulations were carried out by the HADDOCK web server and GROMACS, respectively, to evaluate the interaction between FB24 and EC receptors in silico. The docking results revealed that FB24 exhibited binding activity against potential EC receptors with −1.7 to −2.7 ranged z score and maintained a stable structure. The docked complex of FB24-RAGE (receptor for advanced glycation end products, also known as advanced glycation end product receptor [AGER]) showed 18 hydrogen bonds and 213 non-bonded contacts. It was chosen for further analysis by molecular dynamics simulations by GROMACS. This complex showed a stable condition, and its root mean square deviation (RMSD) was 0.218 nm. The results suggest that FB24 could serve as a suitable carrier vector for transporting therapeutic and diagnostic agents across the BBB to the brain through a non-invasive route.