bluuebunny/crossref_metadata_2025_split huggingface dataset:
EPCAL: ETS Platform for Collaborative Assessment and Learning
Authors: Hao Jiangang , Liu Lei , von Davier Alina A. , Lederer Nathan , Zapata‐Rivera Diego , Jakl Peter , Bakkenson Michael 
Published: October 2017

AbstractMost existing software tools for online collaboration are designed to support the collaboration itself instead of the study of collaboration with a systematic team and task management system. In this report, we identify six important features for a platform to facilitate the study of online collaboration. We then introduce the Educational Testing Service Platform for Collaborative Assessment and Learning (EPCAL), which was developed to encompass these features to enable both large‐scale online collaboration itself and the research on these collaborations. The collaboration management features of the EPCAL also make it an ideal tool for teachers to carry out computer‐supported collaborative learning and assessment activities in classroom settings.
Late Mesozoic transition from Andean‐type to Western Pacific‐type of the East China continental margin—Is the East China Sea basement an allochthonous terrain?
Authors: Ding Weiwei , Li Jiabiao , Wu Zhaocai , Li Sanzhong , Lin Xiubin 
Published: October 2017

Geophysical features and crustal structure of the East China Sea basement were revealed based on geophysical inversion analysis with recent gravity and magnetic data. Our results show great differences between the East China Sea continental shelf basins and the Zhemin Volcanic Belt in the coastal South China Block with respect to geophysical features and crustal structures. These areas are separated by distinct geophysical and crustal changes, approximately along a line 100 km from the coastline of China. We hypothesize that the East China Sea basement is a buoyant allochthon in the Palaeo‐Pacific Plate, and that the East China margin was an Andean‐type active continental margin until the collision of the East China Sea basement with the South China Block in the Late Cretaceous, which jammed the Late Cretaceous Trench, terminating the subduction and the related granitoid magmatism. The East China continental margin was dominated by dextral transtension with limited magmatism due to the NNW‐trend motion of the Palaeo‐Pacific Plate with a reduced convergence rate until the Middle Eocene. The renewed westward subduction of the present‐day Pacific Plate replaced the East China Andean‐type continental margin with a Western Pacific‐type one. The detailed reconstructed tectonic model for the East China Sea since the Mesozoic is presented in this paper.
Geochemistry, geochronology, and geological implications of the granitoids associated with the Dongfengshan gold deposit, Heilongjiang Province, NE China
Authors: Wutiepu Wukeyila , Yang Yanchen , Tan Yan , Han Shijiong , Guo Yufei , Wang Qingshuang , Wang Xueyang , Wang Fengbo 
Published: October 2017

The Dongfengshan gold deposit in Heilongjiang Province of China is located at the western margin of the Jiamusi Massif. The mineralization is closely related to the intrusion of the Permian granite porphyry. In this paper, we present new zircon U–Pb ages and whole‐rock geochemical analyses of the granitoids from the Dongfengshan deposit. They are classified as peraluminous high‐K calc‐alkaline to shoshonitic A‐type granites, with enrichment in the large ion lithophile elements (e.g., Rb, U, and Th) and depletion in the high field strength elements (e.g., Nb, P, Ti, and Zr) and clear negative Eu anomalies. The zircons from the granite porphyry are both magmatic and hydrothermal, with the former yielding ages of 281.7 ± 3.3 and 282.1 ± 3.5 Ma that represent the timing of crystallization of this Early Permian pluton. The hydrothermal zircons yield an age of 280.5 ± 0.3 Ma, representing the hydrothermal age, which coincide with the emplacement of the igneous rocks. These data suggest that the Early Permian magmatic and mineralization event led to the formation of the Dongfengshan gold deposit. In comparison, zircons from the monzogranite yield a weighted age of 523.0 ± 6.4 Ma, indicating that magmatism of the study area occurred in the Early Cambrian. On the basis of the regional geological history and the new geochemical and isotopic data from intrusions, we suggest that diagenesis and mineralization of the Dongfengshan gold deposit took place in a postcollisional extensional tectonic setting during the Early Permian.
Meta‐analysis of test accuracy studies using imputation for partial reporting of multiple thresholds
Authors: Ensor J. , Deeks J.J. , Martin E.C. , Riley R.D. 
Published: October 2017

IntroductionFor tests reporting continuous results, primary studies usually provide test performance at multiple but often different thresholds. This creates missing data when performing a meta‐analysis at each threshold. A standard meta‐analysis (no imputation [NI]) ignores such missing data. A single imputation (SI) approach was recently proposed to recover missing threshold results. Here, we propose a new method that performs multiple imputation of the missing threshold results using discrete combinations (MIDC).MethodsThe new MIDC method imputes missing threshold results by randomly selecting from the set of all possible discrete combinations which lie between the results for 2 known bounding thresholds. Imputed and observed results are then synthesised at each threshold. This is repeated multiple times, and the multiple pooled results at each threshold are combined using Rubin's rules to give final estimates. We compared the NI, SI, and MIDC approaches via simulation.ResultsBoth imputation methods outperform the NI method in simulations. There was generally little difference in the SI and MIDC methods, but the latter was noticeably better in terms of estimating the between‐study variances and generally gave better coverage, due to slightly larger standard errors of pooled estimates. Given selective reporting of thresholds, the imputation methods also reduced bias in the summary receiver operating characteristic curve. Simulations demonstrate the imputation methods rely on an equal threshold spacing assumption. A real example is presented.ConclusionsThe SI and, in particular, MIDC methods can be used to examine the impact of missing threshold results in meta‐analysis of test accuracy studies.
A historical perspective and evolution of the treatment of male urinary incontinence
Authors: Chong Julio T. , Simma‐Chiang Vannita 
Published: October 2017

AimsTo describe the historical changes from antiquity until present in the presentation and treatment of male urinary incontinence.MethodsA literature review of PubMed articles in English pertaining to male incontinence was performed.ResultsMale urinary incontinence was first mentioned in Egyptian manuscripts in 1500 B.C. In 1564, Ambroise Pare designed portable urinals for incontinent males. Wilhem Hildanus created the first condom catheter with pig bladder in the 1600s and was also credited with fashioning the first penile clamp. Lorenz Heister introduced a perineal bulbar urethral compression belt in 1747 which would provide the blueprint for air‐inflated bulbar urethral compression devices such as the one designed by S.A. Vincent in 1960. Robert Gersuny performed the first periurethral paraffin injection bulking therapy in the late 19th century. In 1929, Frederic Foley introduced the modern catheter, and also credited with conception of the first artificial sphincter. From 1970 to 1973, Joseph Kaufman surgically created bulbar compression for post‐prostatectomy incontinence, but not before designing the first male sling with John Berry in 1958. In 1973, F. Brantley Scott introduced the first multi‐component artificial inflatable sphincter. Improvements upon periurethral bulking therapy occurred rapidly in the late 20th century with Teflon, collagen, autologous adipose, tissue and cross‐linked silicone gels. Since 2007, stem cell injection therapy has emerged as a new therapeutic option for incontinence; however, results are mixed and remains experimental.ConclusionTreatment for male urinary incontinence has evolved from noninvasive devices to various surgical procedures. Artificial sphincters remain the gold‐standard therapy for male urinary incontinence.
Improving projection‐based eigensolvers via adaptive techniques
Authors: Galgon Martin , Krämer Lukas , Lang Bruno 
Published: October 2017

SummaryWe consider subspace iteration (or projection‐based) algorithms for computing those eigenvalues (and associated eigenvectors) of a Hermitian matrix that lie in a prescribed interval. For the case that the projector is approximated with polynomials, we present an adaptive strategy for selecting the degree of these polynomials such that convergence is achieved with near‐to‐optimum overall work without detailed a priori knowledge about the eigenvalue distribution. The idea is then transferred to the approximation of the projector by numerical integration, which corresponds to FEAST algorithm proposed by E. Polizzi in 2009. [E. Polizzi: Density‐matrix‐based algorithm for solving eigenvalue problems. Phys. Rev. B 2009; 79:115112]. Here, our adaptation controls the number of integration nodes. We also discuss the interaction of the method with search space reduction methods.
On two high‐order families of frozen Newton‐type methods
Authors: Amat S. , Argyros I. , Busquier S. , Hernández‐Verón M. A. 
Published: October 2017

SummaryThis paper is devoted to the study of two high‐order families of frozen Newton‐type methods. The methods are free of bilinear operators, which constitute the main limitation of the classical high‐order iterative schemes. Both families are natural generalizations of an efficient third‐order method. Although the methods are more demanding, a semilocal convergence analysis is presented using weaker conditions.
Methods for solving underdetermined systems
Authors: Qian Jiang , Andrew Alan L. , Chu Delin , Tan Roger C. E. 
Published: October 2017

SummaryWe compare some alternative methods for computing solutions of underdetermined linear systems, Ax=b. Each method involves solving an associated system with a different nonsingular coefficient matrix,
. We obtain bounds on the condition numbers of these nonsingular matrices and test the methods on numerical examples. We discuss implications for computing eigenvector derivatives and make some recommendations.
Styrene grafted ethylene chlorotrifluoroethylene (ECTFE‐g‐PSSA) protonic membranes: Preparation, characterization, and transport mechanism
Authors: Abdel‐Hamed M.O. 
Published: October 2017

The main goal of the present work is the development of partially fluorinated, low‐cost proton exchange membranes. The styrene grafted onto commercial ethylene chlorotrifluoroethylene (ECTFE) membranes using solution grafting technique, and after that the membranes were sulfonated. Diluting styrene on ECTFE with a solvent mixture of methanol plus methylene chloride (1:1) was highly effective in promoting the grafting reaction as indicated by the increase in the degree of grafting (DG) to 21.3% compared to other solvents. The DG in ECTFE membranes increased with an increase in the monomer concentration up to 60% and then declined. Fourier transform infrared spectroscopic analysis confirmed grafting and sulfonation onto ECTFE films. The maximum value of proton conductivity for ECTFE‐g‐PSSA film with DG = 21.3% was observed to be 141 mS cm−1, which is also higher than those of Nafion 212 membrane. Furthermore, the activation energy of ECTFE‐g‐PSSA membranes was obtained ranging from 8.27 to 9.726 kJ mol−1. So both proton transport mechanisms (hopping and vehicle) have been commonly accepted. The mobility of the charge carriers calculated from proton conductivity data has robust dependence on the grafting yield and temperature. Moreover, the tensile strength and elongation at break ratio decreases with the increase in DG. The water and methanol uptakes increase up to 0.97% and 30%, respectively, for the highest DG value. Finally, the ECTFE‐g‐PSSA has lower cost and higher conductivity they could be better used instead of Nafion in direct methanol fuel cells.
PAM, OLA, and LNA are Differentially Taken Up and Trafficked Via Different Metabolic Pathways in Porcine Adipocytes
Authors: Yu Caihua , Xi Lingling , Chen Jin , Jiang Qin , Yi Hongbo , Wang Yizhen , Wang Xinxia 
Published: October 2017

AbstractDietary fatty acids have different effects on fat deposition in pigs. To clarify the underlying mechanisms of this difference, we compared the metabolism of palmitic (PAM, saturated), oleic (OLA, monounsaturated) and linoleic acid (LNA, polyunsaturated) in porcine adipocytes treated with 100 μM PAM, OLA or LNA. We observed that the adipocytes incubated with LNA accumulated more lipids compared with those treated with PAM and OLA. We then probed the metabolism of these fatty acids in porcine adipocytes by using isotope‐labelled fatty acids. The results showed that 42% of the [1‐14C] LNA, 34% of the [1‐14C] PAM and 28% of the [1‐14C] OLA were recovered in the cellular lipids. The gene expression analyses showed that LNA significantly increased the expression of adipogenesis‐ and oxidation‐related genes including PPARγ, C/EBPα, ap2 and NRF1. In addition, the cells incubated with LNA showed a decreased Ser112 phosphorylation in PPARγ compared to those incubated with PAM and OLA. Furthermore, when PPARγ Ser112 phosphorylation was inhibited, no significant difference in the triacylglycerol contents in the adipocytes was observed. These results showed the dietary fatty acids had different metabolism pathways in porcine adipocytes, and LNA significantly promoted lipid accumulation, probably by regulating PPARγ phosphorylation in adipocytes.
Evaluation of turbulent mixing transition in a shock-driven variable-density flow
Authors: Mohaghar Mohammad , Carter John , Musci Benjamin , Reilly David , McFarland Jacob , Ranjan Devesh 
Published: October 2017

The effect of initial conditions on transition to turbulence is studied in a variable-density shock-driven flow. Richtmyer–Meshkov instability (RMI) evolution of fluid interfaces with two different imposed initial perturbations is observed before and after interaction with a second shock reflected from the end wall of a shock tube (reshock). The first perturbation is a predominantly single-mode long-wavelength interface which is formed by inclining the entire tube to 80$^{\circ }$ relative to the horizontal, yielding an amplitude-to-wavelength ratio, $\unicode[STIX]{x1D702}/\unicode[STIX]{x1D706}=0.088$, and thus can be considered as half the wavelength of a triangular wave. The second interface is multi-mode, and contains additional shorter-wavelength perturbations due to the imposition of shear and buoyancy on the inclined perturbation of the first case. In both cases, the interface consists of a nitrogen-acetone mixture as the light gas over carbon dioxide as the heavy gas (Atwood number, $A\sim 0.22$) and the shock Mach number is $M\approx 1.55$. The initial condition was characterized through Proper Orthogonal Decomposition and density energy spectra from a large set of initial condition images. The evolving density and velocity fields are measured simultaneously using planar laser-induced fluorescence (PLIF) and particle image velocimetry (PIV) techniques. Density, velocity, and density–velocity cross-statistics are calculated using ensemble averaging to investigate the effects of additional modes on the mixing and turbulence quantities. The density and velocity data show that a distinct memory of the initial conditions is maintained in the flow before interaction with reshock. After reshock, the influence of the long-wavelength inclined perturbation present in both initial conditions is still apparent, but the distinction between the two cases becomes less evident as smaller scales are present even in the single-mode case. Several methods are used to calculate the Reynolds number and turbulence length scales, which indicate a transition to a more turbulent state after reshock. Further evidence of transition to turbulence after reshock is observed in the velocity and density fluctuation spectra, where a scaling close to $k^{-5/3}$ is observed for almost one decade, and in the enstrophy fluctuation spectra, where a scaling close to $k^{1/3}$ is observed for a similar range. Also, based on normalized cross correlation spectra, local isotropy is reached at lower wave numbers in the multi-mode case compared with the single-mode case before reshock. By breakdown of large scales to small scales after reshock, rapid decay can be observed in cross-correlation spectra in both cases.
Does intranasal steroid spray technique affect side effects and compliance? Results of a patient survey
Authors: Ganesh V , Banigo A , McMurran A E L , Shakeel M , Ram B 
Published: October 2017

AbstractBackground:Intranasal steroid sprays are fundamental in the medical management of inflammatory rhinological conditions. Side effects are common, but these may be related to the method of application rather than the medication itself.Methods:A survey was distributed to patients using intranasal steroid sprays at the ENT out-patient clinic at Aberdeen Royal Infirmary over three months. This evaluated the spray technique used, side effects and compliance.Results:Of 103 patients, 22 patients (21.4 per cent) reported side effects, including nasal irritation and epistaxis. Of the 20 patients with epistaxis, 80 per cent used an ipsilateral hand technique (p= 0.01). Thirty patients demonstrated poor compliance because of lack of symptom improvement or side effects. Seventy-seven per cent of this group used the ipsilateral hand technique.Conclusion:Patients who used their ipsilateral hand to apply the intranasal steroid spray were more likely to develop epistaxis and have poor compliance than those who used other techniques. Patients who struggle with compliance because of side effects should avoid this method of intranasal steroid application.
“A Fountainhead of Pure Musical Americana”: Hobo Philosophy in Harry Partch'sBitter Music
Authors: RAULERSON GRAHAM 
Published: October 2017

AbstractLargely because of its troubled publication history,Bitter Music—Harry Partch's journal of a portion of his travels as a hobo—has attracted little scholarly or popular attention. This article aims to help elucidateBitter Musicby examining the influence of hobo philosophy on its creation and reception. Certain aspects of the historical and current hobo subculture's ideology—particularly bricolage, anarcho-syndicalism, radical egalitarianism, and non-hierarchical temporal perception—appear to motivate various factors in Partch's creation of the journal and his later attempts to destroy it. Additionally, I examine how hobo philosophy animates Partch's approach to speech, song, and instrumental music, culminating in a close reading of the journal's longest musical-textual entry. The article concludes with an examination of howBitter Music’s publication history further enhances the resonance of hobo philosophy with the ways in which the journal is apprehended by readers and, in the current century, listeners.
Resistance to checkpoint blockade therapy through inactivation of antigen presentation
Authors: Sade-Feldman Moshe , Jiao Yunxin J. , Chen Jonathan H. , Rooney Michael S. , Barzily-Rokni Michal , Eliane Jean-Pierre , Bjorgaard Stacey L. , Hammond Marc R. , Vitzthum Hans , Blackmon Shauna M. , Frederick Dennie T. , Hazar-Rethinam Mehlika , Nadres Brandon A. , Van Seventer Emily E. , Shukla Sachet A. , Yizhak Keren , Ray John P. , Rosebrock Daniel , Livitz Dimitri , Adalsteinsson Viktor , Getz Gad , Duncan Lyn M. , Li Bo , Corcoran Ryan B. , Lawrence Donald P. , Stemmer-Rachamimov Anat , Boland Genevieve M. , Landau Dan A. , Flaherty Keith T. , Sullivan Ryan J. , Hacohen Nir 
Published: October 2017

AbstractTreatment with immune checkpoint blockade (CPB) therapies often leads to prolonged responses in patients with metastatic melanoma, but the common mechanisms of primary and acquired resistance to these agents remain incompletely characterized and have yet to be validated in large cohorts. By analyzing longitudinal tumor biopsies from 17 metastatic melanoma patients treated with CPB therapies, we observed point mutations, deletions or loss of heterozygosity (LOH) in beta-2-microglobulin (B2M), an essential component of MHC class I antigen presentation, in 29.4% of patients with progressing disease. In two independent cohorts of melanoma patients treated with anti-CTLA4 and anti-PD1, respectively, we find that B2M LOH is enriched threefold in non-responders (~30%) compared to responders (~10%) and associated with poorer overall survival. Loss of both copies of B2M is found only in non-responders. B2M loss is likely a common mechanism of resistance to therapies targeting CTLA4 or PD1.
Limiting habenular hyperactivity ameliorates maternal separation-driven depressive-like symptoms
Authors: Tchenio Anna , Lecca Salvatore , Valentinova Kristina , Mameli Manuel 
Published: October 2017

AbstractEarly-life stress, including maternal separation (MS), increases the vulnerability to develop mood disorders later in life, but the underlying mechanisms remain elusive. We report that MS promotes depressive-like symptoms in mice at a mature stage of life. Along with this behavioral phenotype, MS drives reduction of GABAB-GIRK signaling and the subsequent lateral habenula (LHb) hyperexcitability—an anatomical substrate devoted to aversive encoding. Attenuating LHb hyperactivity using chemogenetic tools and deep-brain stimulation ameliorates MS depressive-like symptoms. This provides insights on mechanisms and strategies to alleviate stress-dependent affective behaviors.
Conversion of invisible metal-organic frameworks to luminescent perovskite nanocrystals for confidential information encryption and decryption
Authors: Zhang Congyang , Wang Bo , Li Wanbin , Huang Shouqiang , Kong Long , Li Zhichun , Li Liang 
Published: October 2017

AbstractTraditional smart fluorescent materials, which have been attracting increasing interest for security protection, are usually visible under either ambient or UV light, making them adverse to the potential application of confidential information protection. Herein, we report an approach to realize confidential information protection and storage based on the conversion of lead-based metal-organic frameworks (MOFs) to luminescent perovskite nanocrystals (NCs). Owing to the invisible and controlled printable characteristics of lead-based MOFs, confidential information can be recorded and encrypted by MOF patterns, which cannot be read through common decryption methods. Through our conversion strategy, highly luminescent perovskite NCs can be formed quickly and simply by using a halide salt trigger that reacts with the MOF, thus promoting effective information decryption. Finally, through polar solvents impregnation and halide salt conversion, the luminescence of the perovskite NCs can be quenched and recovered, leading to reversible on/off switching of the luminescence signal for multiple information encryption and decryption processes.