bluuebunny/crossref_metadata_2025_split huggingface dataset:
Implementation of EU Acts in the Czech Parliament: A Slow and Laborious Quest with an Uncertain Outcome
Authors: Říha Michal 
Published: October 2024

Abstract
The article focuses on the statutory implementation practice of EU legislation in the Czech Republic based on statistical evidence. The main focus is a comparison of the length of the legislative procedure in the Parliament from 2010–2021, i.e. three election periods of the Chamber of Deputies, which is the dominant body of law-making in the Czech Republic. In conclusion, the author describes an unusually lengthy implementation process and analyses possible reasons for one of the worst transposition-on-time results within the EU. However, he refutes the claim that the transposition deficit is mostly caused by the Parliament.
Satisfaction Instruments for Nursing Teleconsultations in Reproductive and Sexual Health: an Integrative Review
Authors: Lima Évelyn Cristina Morais Pessôa , Souza Claudinalle Farias Queiroz de , Costa Aurélio Molina da , César Raissa Catarina Vergueiro , Aquino Jael Maria de 
Published: October 2024

Objective: To identify validated instruments for assessing user satisfaction with nursing teleconsultations in reproductive and sexual health.

Theoretical Framework: Nursing teleconsultations in the field of reproductive and sexual health are already a reality. In this context, it is necessary to identify the satisfaction level of people assisted by such services to ensure the need for investments and implementations in healthcare services.

Method: This is an integrative literature review based on the PRISMA methodology. The article search was conducted in the PubMED and LILACs databases and the Web of Science library. Inclusion criteria were original articles published in the last five years, in Portuguese, English, and Spanish. Duplicate articles were excluded.

Results and Discussion: Two articles were identified that present satisfaction instruments for nursing teleconsultations in Reproductive and Sexual Health, both indexed in PUBMED. In addition to these, nine other articles present quantitative and qualitative processes for evaluating nursing teleconsultations. None of the instruments found were validated.

Research Implications: A lack of validated instruments for assessing user satisfaction in nursing teleconsultations in general, including in RSH (Reproductive and Sexual Health), was identified.

Originality/Value: This study contributes to the evidence of the need to develop validated instruments capable of diagnosing user satisfaction with nursing teleconsultations. Without such rigorous assessment, it is imprecise to collect satisfaction data that supports the use of technologies such as nursing teleconsultations.
ОСТАП МАКАРУШКА ПРО ПЕДАГОГІКУ ЯК НАУКУ ВИХОВАННЯ
Authors: Карпенко Ореста , Чепіль Марія 
Published: October 2024

У статті розкрито погляди українського педагога Остапа Макарушки на педагогіку як науку виховання, викладені у підручнику для шкіл і родин “Наука вихованя”. Педагогіка – це мистецтво вести молодь до досконалості, забезпечуючи як фізичне здоров’я, так і духовне збагачення. Педагогіка навчає дорослих мистецтва виховання, яке передбачає глибоке розуміння дитячої психології та фізіології. Педагог повинен не тільки знати, чого хоче досягти, але й уміти передбачити потреби майбутнього суспільства, формувати освічених, моральних та свідомих особистостей. Акцентовано увагу на ідеях правди, добра і краси, які спонукають до постійного розвитк уі самовдосконалення. Підручник є цінним внеском у розвиток теорії виховання.
РОЗВИТОК ІНШОМОВНОГО МОВЛЕННЯ У СТУДЕНТІВ ЗВО УКРАЇНИ
Authors: Подоляк Михайло 
Published: October 2024

Мовлення – одна з найважливіших здібностей розумної людини. Кожний вид мовленнєвої діяльності активізують відповідні фізіологічні та психічні механізми в людині. Мовленнєва діяльність значно залежить від фізіологічного стану організму, здатності слухати, бачити, говорити тощо. Мета дослідження – визначити поняття мовлення, його складові та окреслити особливості розвитку іншомовного мовлення у студентів ЗВО. Читання – це такий вид мовленнєвої діяльності, який передбачає письмову форму спілкування. Слухання або аудіювання – це вид мовленнєвої діяльності, який передбачає усну форму спілкування. Говоріння – це такий вид мовленнєвої діяльності, який передбачає кодування інформації засобами мови, з подальшою її усною передачею іншій людині. Письмо – це найскладніший вид мовленнєвої діяльності, оскільки він вимагає досить високого розумового та психічного розвитку людини. Процес навчання мовленнєвої діяльності повинен включати опанування певного, окремого виду, а усіх загалом. Мовлення – це вища форма психічної діяльності людини, яка реалізується через говоріння, слухання, письмо та читання. Мовлення характеризується певними складовими, до яких належать: мотив, мета, об’єкт, результат.
Outpatient Physiotherapy for Immune-Mediated Necrotizing Myositis With a Positive Outcome: Must Pathology Equal Dysfunction? A Case Report
Authors: Neufeld Alex , Johnson Michael , Wong Christopher K. 
Published: October 2024

BACKGROUND: Necrotizing myositis (NM) is a rare autoimmune systemic condition leading to skeletal muscle destruction visualized on magnetic resonance imaging (MRI). The prognosis is severe progressive muscle weakness leading to functional mobility decline. This case study described outpatient physiotherapy management of NM, not hitherto reported, and the unanticipated outcomes given the diagnosis and MRI findings. CASE PRESENTATION: A 77-year-old female was diagnosed with NM, confirmed on MRI significant for abnormal T2 signal in all muscular compartments of both lower extremities, after 4 months of progressive limb weakness had prevented her from walking independently. Outpatient physiotherapy began 10 months after diagnosis. Examination revealed spinal and peripheral joint hypomobility, lower limb weakness (1 repetition, 30s sit to stand-30STS), functional limitation (14/80, Lower Extremity Functional Scale [LEFS]), and slow gait with rollator. The physiotherapy diagnosis was that musculoskeletal impairments contributed to movement dysfunction, leading to 18 manual therapy and exercise treatments over 19 weeks. OUTCOMES AND FOLLOW-UP: Strength (8 repetition 30STS) and function (49/80 LEFS) improved beyond minimal clinical important differences and gait speed at discharge approximated age-sex-matched normal. DISCUSSION: For this NM case, strength and function improved despite confirmed muscle necrosis and prognosis of progressive muscle degradation after addressing modifiable musculoskeletal impairments. JOSPT Cases 2024;4(4):205-211. Epub 7 October 2024. doi:10.2519/josptcases.2024.0064
Characteristics of risk factors and molecular genetic parameters in children with chronic kidney disease
Authors: Sedashkina O. A. , Kolsanov A. V. , Karas S. I. 
Published: October 2024

Introduction. Information about the health status of children with nephrological pathology includes many manifestations of functional system disorders. However, early diagnosis of chronic kidney disease (CKD) is rarely carried out due to the lack of reliable predictors of this process.The aim: To analyze the association of anamnestic signs, laboratory and genetic research results with chronic kidney disease in children to identify potential predictors of the disease.Material and Methods. The data were obtained from a single-center retrospective catamnestic cohort study (2011–2022). The main group included 128 children with chronic kidney disease aged 1 to 17 years. The comparison group consisted of 30 children without diagnosed kidney pathology aged from 1 to 17 years. There were no statistically significant differences in sex and age between the two groups. The informative value of more than 150 features, including anamnestic ones, the state of the mother’s health during pregnancy, antenatal and perinatal factors, features of the child’s development and manifestation of the disease, the results of clinical, laboratory, and genetic research methods were evaluated. An integrated approach to the study included methods for hypotheses testing on statistical significance of indicators differences, regression analysis, and ROC analysis.Results. Hereditary burden of nephrological pathology in the family, unfavorable course of pregnancy (anemia, toxicosis of the first half), obstetric and somatic pathology in the mother, the serial number of childbirth are associated with the subsequent development of CKD. Erythrocytes in the urine and daily protein loss were detected only in the group of children with CKD. In this group, a decrease in the number of red blood cells, increased erythrocyte sedimentation rate (ESR), allergies at an early age, otitis media, persistent viral and bacterial infections, and a number of signs of connective tissue dysplasia were more common. The main group statistically significantly differed from the comparison group by a number of polymorphic genetic markers. It can be assumed that the polymorphisms AGT1 Thr174Thr, AGT2 Thr235Thr, NO3 C786T are associated with a predisposition to CKD, and the products of polymorphisms AGT1 Thr174Met, AGT2 Met235Met, R1 AGT2 C1166C, NO3 T786T may have a protective effect according to development of CKD.Conclusion. The risk factors for CKD identified in this study can be used to develop software to support medical decision making for early detection of children at high risk of disease progression.
The relationship between iron metabolism markers and parameters of carbohydrate and lipid metabolism in patients with overweight and obesity
Authors: Musina N. N. , Slavkina Ya. S. , Petrukhina D. A. , Zima A. P. , Prokhorenko T. S. , Zavadovskaya V. D. , Saprina T. V. 
Published: October 2024

Background: Hyperferritinemia associated with obesity and insulin resistance is a link between the components of the metabolic syndrome and a possible triggering factor in the pathogenesis of carbohydrate metabolism disorders and dyslipidemia.Aim: To establish possible relationships between ferrokinetic parameters, parameters of lipid and carbohydrate metabolism in overweight and obese patients, and to analyze the possibility of using iron metabolism parameters (ferritin and serum iron) as predictors of carbohydrate metabolism disorders in this cohort of patients.Material and Methods. The study included 52 overweight or obese patients. In the course of the study, patients were stratified into groups depending on the presence of carbohydrate metabolism disorders (CMD), and depending on the state of iron metabolism. Among all patients included in the study, an assessment of anthropometric data, a study of glycated hemoglobin, a standard glucose tolerance test with 75 g of glucose, a study of hematological parameters, as well as biochemical parameters of iron metabolism – the concentration of serum iron, transferrin and ferritin, was carried out.Results. Patients with CMD – impaired glucose tolerance or impaired fasting glycaemia – had significantly higher serum ferritin levels than obese patients without CMD (p = 0.019). In persons with a high level of ferritin, CMD developed significantly more often than in patients with a ferritin content in the range below the 75th percentile (χ2 = 5.278, p = 0.022). According to the ROC analysis, ferritin showed a rather high sensitivity – 75%, and specificity – 84.4% at a diagnostic threshold of 126.65 ng/ml (area under the curve = 0.738; p = 0.016) in the diagnosis of prediabetes (IGT/IFG) in overweight and obese individuals.Conclusion. High concentrations of iron and ferritin are positively associated with CMD, with ferritin being a promising predictor of prediabetes and type 2 diabetes mellitus.
Antifungal activity’s study of the of new derivatives of pyrrolo[3,4-c]pyrazol-3-ones and pyrazol-3- carboxamides in the biofilm model of Candida spp.
Authors: Novikova V. V. , Bobrovskaya O. V. , Gein V. L. 
Published: October 2024

The search for new antifungal drugs is current interest due to the wide spread of fungal infections. To simulate the antifungal effect of new promising compounds with high antifungal activity in planktonic culture in clinical practice, it is necessary to study their effect on the biofilm of micromycetes.Aim: To study the antifungal activity of new promising representatives of silver salts of pyrazoles and their condensed systems under conditions of biofilm formation.Material and Methods. To study the antifungal activity of silver salts I and II, the micromethod of two-fold serial dilutions was used. Activity against a typical and 14 clinical highly virulent isolates of C. albicans was studied. The study of the antimycotic activity of substances under biofilm conditions was carried out using resazurin to quantify the degree of biofilm formation. The minimum inhibitory concentrations for biofilms were calculated (sMIC50 - the concentration of the antifungal substance at which a 50% decrease in fluorescence is observed compared to the positive control).Results and Discussion. It was shown that the antifungal effect of the studied compounds in biofilm culture of clinical strains of Candida spp. is significantly lower than in planktonic culture. High antifungal activity of the silver salt of pyrazole-3- carboxamide in planktonic and biofilm cultures of resistant strains of Candida albicans, exceeding the effect of the reference drug fluconazole by 2.8–11.2 times, was revealed.Conclusion. A promising pyrazole-3-carboxamide derivative has been identified that effectively inhibits the growth of Candida albicans biofilms, which can be recommended for further study.
Changes in electrical parameters of the heart in an experimental model of malignant tumor growth during of hyperthyroidism
Authors: Frantsiyants E. M. , Kaplieva I. V. , Sheiko E. A. , Surikova E. I. , Vasileva E. O. , Neskubina I. V. , Gusareva M. A. , Bykadorova O. V. , Trepitaki L. K. , Cheryarina N. D. , Serdyukova E. V. , Vereskunova A. A. 
Published: October 2024

Experimental and clinical studies demonstrate the possibility of modulating the development of malignant tumors in thyroid imbalance, in particular hyperthyroidism, which negatively affects the electrophysiology of the heart. In an experimental model of tumor growth during of hyperthyroidism, activation of the tumor was shown.Aim: To study electrophysiological parameters of the mouse heart at the initial stages of transplantable tumor growth during of hyperthyroidism.Material and Methods. In female mice of the C57BL/6 line (n = 20) was created a model of melanoma B16/F10 growth during of hyperthyroidism, which was induced by daily intraperitoneal administration of liothyronine sodium (T3) for a long time and confirmed by determining the content of thyroid-stimulating hormone and triiodothyronine in the blood using the radioimmune method. On the 5th day of T3 administration, the melanoma was transplanted. ECG was recorded non-invasively (ecgTUN- NEL, ecgAVG software, emka TECHNOLOGIES, France) on the 1st and 3rd days of T3 administration, in groups with a tumor – on the 6th day after its transplantation.Results. Pathological changes were revealed: in the group with hyperthyroidism – rhythm irregularity, decrease the amplitude of P and T below the isoline, widening of the QRS, on the 3rd day – the death of 1 mouse was noted due to large-focal myocardial infarction; in the group with melanoma – only sinus arrhythmia and decreased heart rate; in the group with a combination of pathologies – an almost normal ECG, with the exception of an increase in P amplitude and a slight increase in QRS.Conclusion. Already in the early stages of hyperthyroidism or tumor growth, there was a violation of myocardial depolarization/ repolarization processes, capable of causing even death of the animal. In case of comorbidity, the majority of ECG parameters normalized, indicating the inclusion of compensatory mechanisms in the interaction of pathologies. The results demonstrate the need for a deeper study of the mechanisms of interaction of several simultaneously existing pathologies in the body.
Comparative analysis of the structure of the heart and blood vessels surgeries, taking into account the clinical and functional status of patients with coronary heart disease in 2015 and 2020
Authors: Efros L. A. , Lukin O. P. , Belogorokhov V. S. , Ushakov A. Yu. 
Published: October 2024

Relevance. In a very short period of time, surgical treatment methods have become widespread due to the expansion of indicators for performing heart surgery in patients with severe complicated forms of coronary heart disease and the use of combined surgical operations.Aim: To study changes in the clinical and functional status of patients depending on the type of surgical intervention for coronary artery disease in different time periods in the gender aspect.Material and Methods. The study was conducted retrospectively. For comparative analysis, patients with an established diagnosis of coronary heart disease who underwent surgical treatment at the Federal Center for Cardiovascular Surgery of the of the Ministry of Healthcare of the Russian Federation (Chelyabinsk) in 2015 (n = 1017) and 2020 (n = 967) were included. Of the total number of patients in 2015, there were 771 (75.8%) men and 246 (24.2%) women, in 2020 718 (74.3%) and 249(25.7%), respectively.Results. In the structure of interventions performed, there is a decrease in the number of almost all types of surgical interventions for complications of myocardial infarction, most pronounced in relation to resection of the left ventricular aneurysm, reconstruction of the left ventricle and operations in combination with mitral valve replacement. In a large percentage of cases, patients with a history of risk factors for cardiovascular diseases are referred for coronary artery bypass surgery, regardless of gender. The majority of patients had angina pectoris of the 3rd–4th functional class. However, there is a trend towards a decrease in the proportion of people with post-infarction cardiosclerosis when referred for surgery.Conclusion. Despite the significant volume and availability of practical information, the number of patients with major cardiovascular risk factors is not decreasing.
Numerical model of the aortic valve prosthetic frame
Authors: Klyshnikov K. Yu. , Ovcharenko E. A. , Onishchenko P. S. , Glushkova T. V. , Akentyeva T. N. , Kostyunin A. E. , Rezvova M. A. , Barbarash O. L. 
Published: October 2024

Aim: To perform a quantitative analysis of the effectiveness of three concepts of heart valve prosthesis support frames from the perspective of their safety under the most critical loads, conducted through numerical modeling.Materials and Methods. The study utilized three computer-generated concepts of stent-like support frames, created based on the analysis of similar balloon-expandable prostheses. The modeling was conducted using Abaqus/CAE software and included the analysis of two key loads characteristic for this element: compression and implantation phases. A linear description of cobalt-chromium was used as the material model. The feasibility of the concepts was quantitatively assessed using von Mises stress and its qualitative distribution on the surface of the models as stress contours.Results. The analysis revealed that two of the three proposed models experienced stresses exceeding the strength limit (933 MPa) – 999.6 and 954.0 MPa during the compression phase and reaching 1022.4 and 1044.7 MPa, respectively, during the implantation phase. Concept 3 had significantly lower stresses during loading; however, in the working state, the indicators approached the threshold, reaching 924.2 MPa.Conclusion. Numerical modeling identified the inefficacy of concepts 1 and 2 and directions for optimizing concept 3 – reducing amplitudes to form a “strength reserve” for stress. The analysis emphasized the importance of numerical modeling in the early assessment and optimization of medical devices.
Angiotensin 1-7 – a peptide that increases the resistance of the heart to ischemia and reperfusion: narrative review
Authors: Mukhomedzyanov A. V. , Popov S. V. , Maslov L. N. , Naryzhnaya N. V. , Sirotina M. A. , Kurbatov B. K. , Gorbunov A. S. , Kilin M. , Kan A. , Krylatov A. V. , Podoksenov Yu. K. , Stepanov I. V. 
Published: October 2024

Background. The high mortality rate among patients with acute myocardial infarction (AMI) is an important problem of modern cardiology. In recent years, there has not been a significant decrease in mortality in AMI. Drugs used to treat AMI are not effective enough, so there is a need to develop fundamentally new drugs that can significantly increase the heart’s tolerance to ischemia/reperfusion (I/R). Angiotensin 1-7 peptide, which can increase cardiac tolerance to I/R by activating Mas receptor in myocardial tissue, could become a prototype of such drugs. The following enzymes are involved in the formation of the cardioprotective effect of angiotensin 1-7: NO-synthase, soluble guanylyl cyclase, phosphoinositide 3-kinase, extracellular signal-regulated kinases-1/2, Akt kinase and, possibly, protein kinase G. Indirect data indicate that the hypothetical end effector in the cardioprotective impact of angiotensin 1-7 could be mitochondrial or sarcolemmal ATP-sensitive K+ channel.Aim: To review 1-7 role in increasing the heart resistance to ischemia and reperfusion. The literature search was carried out in the PubMed database with queries “angiotensin 1-7 receptors”, “stress”, “angiotensin 1-7”, “mas receptor”, “cardioprotective effects of angiotensin 1-7”.
Mechanical dyssynchrony in patients with chronic heart failure and left bundle branch block
Authors: Mamedova A. I. , Prihod’ko N. A. , Lubimceva T. A. , Kozlenok A. V. , Lebedev D. S. 
Published: October 2024

Background. The main problem in patient selection for cardiac resynchronization therapy (CRT) is the lack of unified approaches to the definition of mechanical dyssynchrony (MD) and selection criteria, particularly, in patients with left bundle branch block (LBBB).Aim: To study mechanical dyssynchrony indices and three-dimensional Echo (3DE) criteria of global and local contractility function in patients with chronic heart failure (CHF) and LBBB during different types of isolated left ventricle (LV) pacing.Methodology and Research Methods. The experimental intraoperative study involved 88 points obtained from 12 patients with CRT class IA indications and LBBB. During isolated LV pacing as part of CRT implantation procedure endocardial and epicardial pacing were obtained. Transesophageal Echo (TEE) cineloops recording and paced QRS complex morphology registrations by means of LabSystem Pro Electrophysiological Recording System (Bard Electrophysiology, USA) were performed during each stimulation episode. Philips Qlab 10 software was used for TEE data analysis.Results. The global (3D EF, 23.8 [22; 28.4], GLS, –5.33% [10.90%; –15.4%]) and local contractility (ExсAvg 3.5 [2.1; 5.6]) criteria and dyssyncrony indices (SDI-16, 14.9 [8.9; 23.1]) showed severe systolic dysfunction and intraventricular dyssynchrony – typical signs in this patient group, and differed significantly (3D EF, p = 0.003; GLS, p = 0.004; ExcAvg, p < 0.001; Tmsv-6 SD, р = 0.03) depending on the stimulation method and site. A moderate direct correlation between SDI-16 and the QRS duration (common electical dyssynchrony criterium) and inverse correlation with ExcAvg and 3D LVEF also describes LV response.