bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterisation of asthma subgroups associated with circulating YKL-40 levels
Authors: Gomez Jose L. , Yan Xiting , Holm Carole T. , Grant Nicole , Liu Qing , Cohn Lauren , Nezgovorova Vera , Meyers Deborah A. , Bleecker Eugene R. , Crisafi Gina M. , Jarjour Nizar N. , Rogers Linda , Reibman Joan , Chupp Geoffrey L. 
Published: October 2017

The chitinase-like protein YKL-40 mediates airway inflammation and serum levels are associated with asthma severity. However, asthma phenotypes associated with YKL-40 levels have not been precisely defined.We conducted an unsupervised cluster analysis of asthma patients treated at the Yale Center for Asthma and Airways Disease (n=156) to identify subgroups according to YKL-40 level. The resulting YKL-40 clusters were cross-validated in cohorts from the Severe Asthma Research Programme (n=167) and the New York University/Bellevue Asthma Repository (n=341). A sputum transcriptome analysis revealed molecular pathways associated with YKL-40 subgroups.Four YKL-40 clusters (C1–C4) were identified. C3 and C4 had high serum YKL-40 levels compared with C1 and C2. C3 was associated with earlier onset and longer duration of disease, severe airflow obstruction, and near-fatal asthma exacerbations. C4 had the highest serum YKL-40 levels, adult onset and less airflow obstruction, but frequent exacerbations. An airway transcriptome analysis in C3 and C4 showed activation of non-type 2 inflammatory pathways.Elevated serum YKL-40 levels were associated with two distinct clinical asthma phenotypes: one with irreversible airway obstruction and another with severe exacerbations. The YKL-40 clusters are potentially useful for identification of individuals with severe or exacerbation-prone asthma.
Coordinating Movements: The Politics of Cuban-Mexican Dance Exchanges, 1959–1983
Authors: Schwall Elizabeth 
Published: October 2017

AbstractThis article analyzes the politics of dance collaborations between Cubans and Mexicans from 1959 to 1983. During this period, Mexican modern dancers worked in Cuba, and Cuban ballet dancers in Mexico. Over years of close, visceral encounters, Mexican and Cuban dancers built cultural institutions and international relationships filled with emotional ups and downs. Focusing on the sentiments that guided dancing revolutionaries, this article examines the everyday process of international relations as creative diplomats from Cuba and Mexico coordinated movements in classes, rehearsals, and performances. This article contends that in contrast to the friendly but distant bilateral relations forged by elite politicians in a tense Cold War context, dancers made the Cuban-Mexican relationship an intimate, creative partnership among revolutionary citizens. This demonstrates how the personal and interpersonal, in dialogue with geopolitics and ideology, shaped the cultural Cold War in Latin America and how it changed over time.
Διερεύνηση των αντιλήψεων των παιδιών σχετικά με πρακτικές αφηγηματικής δραστηριότητας στο σπίτι: Μια δημογραφική έρευνα για την αφήγηση παραμυθιών στο νομό Φλώρινας
Authors: Mastrothanasis Konstantinos , Papakosta Alexia 
Published: October 2017

Η αφηγηματική δραστηριότητα αποτελεί μια καθιερωμένη πρακτική αλληλεπίδρασης ανάμεσα στους ενηλίκους και τα παιδιά. Ως φαινόμενο, συνδέεται άμεσα με την ανάγκη αναπαραγωγής της πολιτισμικής κληρονομιάς και συμβάλλει στην καλλιέργεια κοινωνικής κουλτούρας. Συνήθως αναπτύσσεται στα στενά πλαίσια της οικογένειας, λόγω των ισχυρών συναισθηματικών δεσμών που διαμορφώνονται μέσα σε αυτή και συγχρόνως, αποκτά παιδευτική αξία και εκπαιδευτικά χαρακτηριστικά. Σκοπός της παρούσας εργασίας είναι η διερεύνηση των αντιλήψεων και των απόψεων των παιδιών σχετικά με τις πρακτικές αφηγηματικής δραστηριότητας στο σπίτι, όπως επίσης και η ανίχνευση των παραγόντων που επιδρούν ή συσχετίζονται με αυτή. Η έρευνα, που έχει δημογραφικό χαρακτήρα, βασίστηκε στο σύνολο των μαθητών που φοιτούσε τη σχολική χρονιά 2005-2006 στα δημοτικά σχολεία του νομού Φλώρινας.Σύμφωνα με τα αποτελέσματα, σχεδόν το σύνολο των παιδιών αρέσκονται στην αφήγηση παραμυθιών από ενηλίκους στο σπίτι. Βέβαια, παρότι μέλη της οικογένειας αφηγούνταν με μεγαλύτερη συχνότητα παραμύθια στα παιδιά τους σε μικρότερη ηλικία, μόνο στα μισά περίπου από αυτά συνεχίζουν την αφηγηματική δραστηριότητα, ενώ εμφανίζονται διαφυλικές, ηλικιακές και άλλες διαφορές. Οι λόγοι απουσίας της αφηγηματικής δραστηριότητας σχετίζονται με νοησιαρχικές αντιλήψεις που έχουν εγκαθιδρυθεί από το άμεσο περιβάλλον του παιδιού στο ίδιο το παιδί, ενώ τέλος τον αφηγηματικό ρόλο μέσα στα πλαίσια της οικογένειας ασκούν κατά κύριο λόγο τα θήλεα μέλη της. Από τις αναφορές των παιδιών φαίνεται ότι οι αφηγήσεις εστιάζονται στην κλασική λογοτεχνία.
Σεξουαλική αγωγή ανά τον κόσμο, με έμφαση στις ευρωπαϊκές χώρες, για παιδιά προσχολικής και σχολικής ηλικίας: μία συστηματική ανασκόπηση
Authors: Μπρουσκέλη (Vassiliki Brouskeli) Βασιλική 
Published: October 2017

Η σεξουαλικότητα αποτελεί βασική πτυχή της ανθρώπινης ύπαρξης και η σεξουαλική αγωγή είναι ανθρώπινο δικαίωμα που οι περισσότερες χώρες του κόσμου έχουν αναγνωρίσει. Στόχος της παρούσας μελέτης είναι να διερευνήσει τα υπάρχοντα προγράμματα σεξουαλικής αγωγής ανά τον κόσμο με έμφαση στις ευρωπαϊκές χώρες. Όσον αφορά τη μεθοδολογία, η μελέτη πραγματοποιήθηκε μέσω ηλεκτρονικής αναζήτησης σε βάσεις δεδομένων των σύγχρονων προγραμμάτων σεξουαλικής αγωγής ανά τον κόσμο. Οι μελέτες που συμπεριλήφθηκαν στην ανασκόπηση όφειλαν, μεταξύ άλλων, να παρέχουν επαρκή δεδομένα προς παρουσίαση για δύο σημαντικούς παράγοντες, αυτούς της ηλικίας των παιδιών στα οποία παρέχεται η αγωγή και του περιεχομένου αυτής. Όσον αφορά την Ευρώπη, παρουσιάζονται τα προγράμματα στην Ελλάδα, την Κύπρο, την Ολλανδία, την Αγγλία, τη Γερμανία, την Ιταλία και την Φινλανδία. Όσον αφορά τον υπόλοιπο κόσμο, αναλύονται τα προγράμματα στις Ηνωμένες Πολιτείες της Αμερικής, στην περιοχή της Ασίας-Ειρηνικού, στην Αφρική, τη Λατινική Αμερική και την Αυστραλία. Σύμφωνα με τα αποτελέσματα της μελέτης, οι χώρες που εφαρμόζουν πολύπλευρα προγράμματα αγωγής, σταθερά στον χρόνο, με σύγχρονη μεθοδολογία και περιλαμβάνουν επίκαιρα ζητήματα προς ανάλυση επιδεικνύουν καλύτερα αποτελέσματα της προσπάθειάς τους να εκπαιδεύσουν τους νέους. Επιπλέον, η σεξουαλική αγωγή η οποία έχει στο επίκεντρό της την προσωπική ανάπτυξη και έχει ως αρχή την αντιμετώπιση της σεξουαλικότητας κατά την εφηβεία ως ευκαιρία για προσωπική εξέλιξη και όχι ως απειλή, είναι αποτελεσματικότερη. Τέλος, κρίνεται σκόπιμο τα μελλοντικά σχετικά προγράμματα να αξιολογούνται σε τακτά χρονικά διαστήματα, να λαμβάνουν υπόψη το αναπτυξιακό στάδιο των παιδιών και το εκάστοτε πολιτιστικό και κοινωνικό τους περιβάλλον.
Web literacy practices of teacher education students and in-service teachers in Greece : a descriptive study
Authors: Bougatzeli Evangelia , Douka Maria , Bekos Nikolaos , Papadimitriou Efi 
Published: October 2017

: In the expanding context of new literacies and multiliteracies, the abilities to know how to locate, to evaluate and to exploit Web information resources in order to construct knowledge, are acknowledged as extremely important worldwide. Current literacy curricula should encourage the development of such abilities, and their successful implementation requires teachers themselves to be properly prepared. The present study reports the web searching and evaluating practices for educational purposes employed by both pre-service and in-service teachers. Data was collected via an anonymous online questionnaire. The comparative study exhibis teachers' web practices with the purpose of identifying aspects of web literacy that require attention when designing and implementing relevant educational initiatives. According to the research findings, both pre-service and in-service teachers are based almost exclusively on popular search engines to locate web information resources, and they choose such resources without examining their wider context. In order to evaluate web information resources, they consider mainly morphological and design elements, rather than content features such as their origin and credibility. The findings raise the potential of applying critical literacy principles on the Web so that teachers can approach it critiquely.[1] when using its resources in educational settings. [1] learn to think “critiquely” (a word coined by James Paul Gee), that is, not merely consume information but also “understand and critique systems of power and injustice in a world that [people] will see as simply economically inevitable" (Gee, 2000: 62).
Patient predictors of poor drug sensitive tuberculosis treatment outcomes in Kyiv Oblast, Ukraine
Authors: Aibana Omowunmi , Slavuckij Andrej , Bachmaha Mariya , Krasiuk Viatcheslav , Rybak Natasha , Flanigan Timothy P. , Petrenko Vasyl , Murray Megan B. 
Published: October 2017

Background: Ukraine has high rates of poor treatment outcomes among drug sensitive tuberculosis (DSTB) patients, while global treatment success rates for DSTB remain high. We evaluated baseline patient factors as predictors of poor DSTB treatment outcomes. Methods: We conducted a retrospective analysis of new drug sensitive pulmonary TB patients treated in Kyiv Oblast, Ukraine between November 2012 and October 2014. We defined good treatment outcomes as cure or completion and poor outcomes as death, default or treatment failure. We performed logistic regression analyses, using routine program data, to identify baseline patient factors associated with poor outcomes. Results: Among 302 patients, 193 (63.9%) experienced good treatment outcomes while 39 (12.9%) failed treatment, 34 (11.3%) died, and 30 (9.9%) defaulted. In the multivariate analysis, HIV positive patients on anti-retroviral therapy (ART) [OR 3.50; 95% CI 1.46 – 8.42; p 0.005] or without ART (OR 4.12; 95% CI 1.36 – 12.43; p 0.01) were at increased risk of poor outcomes. Alcohol abuse (OR 1.81; 95% CI 0.93 - 3.55; p 0.08) and smear positivity (OR 1.75; 95% CI 1.03 - 2.97; p 0.04) were also associated with poor treatment outcomes. Conclusions: High rates of poor outcomes among patients with newly diagnosed drug sensitive TB in Kyiv Oblast, Ukraine highlight the urgent need for programmatic interventions, especially aimed at patients with the highest risk of poor outcomes.
Puzzle—Solving Smartphone Puzzle Apps by Mathematical Programming
Authors: Hartmann Sönke 
Published: October 2017

This paper considers six logic puzzles (i.e., single player games) that are available as smartphone apps. The six logic puzzles are: Thermometer Puzzles, Kakuro (Cross Sums), Match 22: Color Puzzle Game, ∞ Infinity Loop, Slider, and Flow Free. We provide mathematical models that can be applied to obtain solutions for these puzzles. In OR/MS lectures, the apps and models can be used as examples or exercises when teaching mathematical programming and for discussion of familiar model types such as shortest path and network flow models. Given the popularity of logic puzzle apps on smartphones, such exercises might be motivating for students. The level of difficulty of the models presented here varies from easy to more difficult. The MathProg files are available at https://www.informs.org/Publications/Subscribe/Access-Restricted-Materials .
Alteration in hypoplasia of the hindfoot structures during early growth in clubfeet treated using the Ponseti method
Authors: Beck J. J. , Sangiorgio S. N. , Jew M. H. , Marcum T. , Cooper S. D. , Ebramzadeh E. , Zionts L. E. 
Published: October 2017

Purpose Previous reports have demonstrated diminished size of the hindfoot bones in patients with idiopathic clubfoot deformity. However, no study has quantified the percentage of hypoplasia as a function of early growth, during the brace phase of Ponseti treatment. Methods We measured the dimensions of ossified structures on radiographs in patients with unilateral Ponseti-treated clubfeet to determine changes in the percentage of hypoplasia between two and four years of age. Results The degree of hypoplasia varied among the osseous structures in Ponseti-treated clubfeet at age two years, with greater hypoplasia being observed in the talus (7.3%), followed by calcaneus (4.9%) and the cuboid (4.8%). Overall, the degree of hypoplasia diminished by four years, such that the degree of hypoplasia was greatest in the talus (4.2%) and the calcaneus (4.2%) followed by the cuboid (0.6%). At four years of age, the greatest degree of hypoplasia persisted in the talus and calcaneus. Conclusions Changes occurred in the size of the ossification of hindfoot bones between two and four years of age, and the observed changes in the percentage of hypoplasia varied among the different structures. At four years of age, the greatest percentage of hypoplasia was observed in the talus and calcaneus at values similar to those previously reported in skeletally mature patients. The results suggested that the relative difference in size of the feet may be expected to remain constant in a child with a unilateral clubfoot after this age.
The influence of bone mineral density and cortical index on the complexity of fractures of the proximal humerus
Authors: den Teuling J.W.A.M. , Pauwels B.S. , Janssen L. , Wyers C.E. , Janzing H. M. J. , van den Bergh J.P.W. , Morrenhof J. W. 
Published: October 2017

Objectives The goal of this study is to investigate the relation between indicators of osteoporosis (i.e., bone mineral density (BMD), and Cortical Index (CI)) and the complexity of a fracture of the proximal humerus as a result of a low-energy trauma. Methods A retrospective chart review of 168 patients (mean age 67.2 years, range 51 to 88.7) with a fracture of the proximal humerus between 2007 and 2011, whose BMD was assessed at the Fracture Liaison Service with Dual Energy X-ray Absorptiometry (DXA) measurements of the hip, femoral neck (FN) and/or lumbar spine (LS), and whose CI and complexity of fracture were assessed on plain anteroposterior radiographs of the proximal humerus. Results No significant differences were found between simple and complex fractures of the proximal humerus in the BMD of the hip, FN or LS (all p > 0.3) or in the CI (p = 0.14). Only the body mass index was significantly higher in patients with a complex fracture compared with those with a simple fracture (26.9 vs 25.2; p = 0.05). Conclusion There was no difference in BMD of the hip, FN, LS or CI of the proximal humerus in simple compared with complex fractures of the proximal humerus after a low-energy trauma. Factors other than the BMD and CI, for example body mass index, may play a more important role in the complexity of this fracture. Cite this article: J.W.A.M. den Teuling, B.S. Pauwels, L. Janssen, C.E. Wyers, H. M. J. Janzing, J.P.W. van den Bergh, J. W. Morrenhof. The Influence of bone mineral density and cortical index on the complexity of fractures of the proximal humerus. Bone Joint Res 2017;6:584–589. DOI: 10.1302/2046-3758.610.BJR-2017-0080.
How 3D patient-specific instruments improve accuracy of pelvic bone tumour resection in a cadaveric study
Authors: Sallent A. , Vicente M. , Reverté M. M. , Lopez A. , Rodríguez-Baeza A. , Pérez-Domínguez M. , Velez R. 
Published: October 2017

Objectives To assess the accuracy of patient-specific instruments (PSIs) versus standard manual technique and the precision of computer-assisted planning and PSI-guided osteotomies in pelvic tumour resection. Methods CT scans were obtained from five female cadaveric pelvises. Five osteotomies were designed using Mimics software: sacroiliac, biplanar supra-acetabular, two parallel iliopubic and ischial. For cases of the left hemipelvis, PSIs were designed to guide standard oscillating saw osteotomies and later manufactured using 3D printing. Osteotomies were performed using the standard manual technique in cases of the right hemipelvis. Post-resection CT scans were quantitatively analysed. Student’s t-test and Mann–Whitney U test were used. Results Compared with the manual technique, PSI-guided osteotomies improved accuracy by a mean 9.6 mm (p < 0.008) in the sacroiliac osteotomies, 6.2 mm (p < 0.008) and 5.8 mm (p < 0.032) in the biplanar supra-acetabular, 3 mm (p < 0.016) in the ischial and 2.2 mm (p < 0.032) and 2.6 mm (p < 0.008) in the parallel iliopubic osteotomies, with a mean linear deviation of 4.9 mm (p < 0.001) for all osteotomies. Of the manual osteotomies, 53% (n = 16) had a linear deviation > 5 mm and 27% (n = 8) were > 10 mm. In the PSI cases, deviations were 10% (n = 3) and 0 % (n = 0), respectively. For angular deviation from pre-operative plans, we observed a mean improvement of 7.06° (p < 0.001) in pitch and 2.94° (p < 0.001) in roll, comparing PSI and the standard manual technique. Conclusion In an experimental study, computer-assisted planning and PSIs improved accuracy in pelvic tumour resections, bringing osteotomy results closer to the parameters set in pre-operative planning, as compared with standard manual techniques. Cite this article: A. Sallent, M. Vicente, M. M. Reverté, A. Lopez, A. Rodríguez-Baeza, M. Pérez-Domínguez, R. Velez. How 3D patient-specific instruments improve accuracy of pelvic bone tumour resection in a cadaveric study. Bone Joint Res 2017;6:577–583. DOI: 10.1302/2046-3758.610.BJR-2017-0094.R1.
Screening for nutritional risk in hospitalized children: comparison of two instruments
Authors: Novianti Dwi , Sembiring Tiangsa , Sofyani Sri , Faranita Tri , Pratita Winra 
Published: October 2017

Background Malnutrition in hospitalized children has negative impact on morbidity, mortality, length of stay, and health-care cost. A simple screening tool is needed to detect hospital malnutrition risk in children.Objective To compare the level of agreement of the Screening Tool for Malnutrition in Pediatrics (STAMP) and Pediatric Nutritional Risk Score (PNRS) with anthropometric measurements, as screening tools for hospital malnutrition in children.Methods A cross-sectional study was conducted from February to July 2014 in the Pediatric and Surgery Wards at H. Adam Malik Hospital, Medan, North Sumatera. Inclusion criteria were children aged 2 to 18 years who were hospitalized for more than 72 hours. Subjects were screened using STAMP and PNRS, and underwent anthropometric measurement on admission. The weight measurements were repeated on the 3rd and 7th days, and just before discharge. The STAMP and PNRS results were compared in terms of level of agreement with anthropometric measurements. Data were analyzed by Kappa value and Spearman’s correlation test.Results A total of 127 children were screened with both instruments. The PNRS had slight agreement with hospital malnutrition prevalence (κ=0.175; P=0.028), while STAMP had not (κ=0.080; P=0.193). Both screening tools had weak positive correlations with length of stay, but the correlation was stronger for PNRS than for STAMP (r=0.218; P=0.014 vs. r=0.188; P=0.034, respectively). The prevalence of hospital malnutrition was 40.9%. Conclusions The PNRS screening tool has slight agreement with anthropometric measurement for identifying hospital malnutrition risk in children.
Effectiveness of ferric sodium edentate supplementation in children with lead poisoning
Authors: Salendu Praevilia , Masloman Nurhayati , Warouw Sarah M. 
Published: October 2017

Background Lead is a harmful toxin that affects human health worldwide, especially in children. Lead poisoning remains a global problem both in developed and developing countries. The Centers for Disease Control and Prevention (CDC) recommends nutritional intervention with iron supplementation to efficiently control high lead levels. Iron supplementation in the form of sodium ferric ethylene-diaminetera-acetic acid/ ferric sodium edentate (NaFeEDTA) is highly bioavailable.Objective To determine the effectiveness of ferric sodium edentate (NaFeEDTA) on lead levels in children woaj ;ead [pospmomg.Methods This interventional, analytical study, had a one group pretest-posttest design, and was done on children in four elementary schools in the Talawaan District, North Minahasa Regency from August to November 2014. Inclusion criteria were elementary students aged 6-9 years with lead poisoning (lead levels ≥ 10 μg/dL) and good nutritional status. Subjects were given NaFeEDTA 115.4 mg (15 mg elemental iron) at a dosage of 3 mg/kgBW/day elemental iron given between meal times. Iron supplementation was given daily per oral route for 12 weeks. Descriptive analysis was used to analyze the characteristics of the study sample. Pre- and post-test analyses were done with paired T-tests. Significance level was P <0.05.Results In this study, 39 children met the inclusion criteria and consisted of 19 boys and 20 girls. Their mean age was 8.43 (SD 0.44) years. Pre-test and post-test blood lead levels was 36.18 μg/dL and 5.22 μg/dL, respectively.There was a significant reduction in mean blood lead levels after administration of NaFeEDTA (P <0.0001).Conclusion In children with lead poisoning, blood lead levels are significantly reduced after 12 weeks of NaFeEDTA supplementation.
Teletrabajadores: entre los discursos optimistas y los contextos precarizados. Una aproximación desde el caso argentino
Authors: Rodríguez Alejandro Damián , D´Errico Julieta 
Published: October 2017

Este artículo pretende aportar al conocimiento del teletrabajo para el caso argentino, prestando especial atención a la perspectiva de una multiplicidad de actores que tienen intereses distintos sobre él, incluso contrapuestos si se toma en consideración la dicotomía capital-trabajo. Con base en una metodología cualitativa se elaboró, por un lado, un análisis de fuentes para dar cuenta de lo que algunos actores específicos de la órbita estatal y de los medios masivos de comunicación sostienen sobre esta modalidad laboral. Por otro lado, se efectuaron once entrevistas en profundidad a teletrabajadores del Área Metropolitana de Buenos Aires (amba) entre el 2013 y el 2017. A partir del cruce de estas dos fuentes de información, se cotejaron discursos muy distintos que abren un serio interrogante sobre el optimismo con que la mayoría de las veces se considera a esta nueva modalidad laboral. Para aportar al conocimiento del teletrabajo, se muestra la manera como este es comprendido por el Ministerio de Trabajo, Empleo y Seguridad Social (mteyss) de Argentina a través del Programa de Promoción del Empleo en Teletrabajo (propet) y por algunos periódicos de circulación nacional como Clarín y La Nación. Este ejercicio evidencia que una mirada demasiado optimista aglutina sus puntos de vista. Flexibilidad, libertad, creatividad, horizontalidad son algunas de las características que, desde su perspectiva, constituye la realidad laboral de los teletrabajadores. Sin embargo, a partir de las entrevistas se encontró que existe una gran brecha entre lo que los actores mencionados afirman sobre el teletrabajo y lo que ocurre en el día a día laboral de los teletrabajadores. Pues estos reconocen algunos beneficios de esta modalidad laboral pero también muchos perjuicios: falta de referentes jerárquicos claros a quiénes dirigirse, objetivos de trabajo difusos, separaciones difíciles entre el ámbito laboral y el hogar son algunos de los más evidentes. Es necesario recalcar que este texto constituye una primera indagación exploratoria realizada con un grupo de entrevistas reducido, razón por la cual las conclusiones son de índole muy preliminar.