bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unplanned Start on Peritoneal Dialysis Right after Pd Catheter Implantation for Older People with End-Stage Renal Disease
Authors: Povlsen Johan V. , Sørensen Anette Bagger , Ivarsen Per 
Published: December 2015

Unplanned start on dialysis remains a major problem for the dialysis community worldwide. Late-referred patients with end-stage renal disease (ESRD) and urgent need for dialysis are overrepresented among older people. These patients are particularly likely to be started on in-center hemodialysis (HD), with a temporary vascular access known to be associated with excess mortality and increased risks of potentially lethal complications such as bacteremia and central venous thrombosis or stenosis. The present paper describes in detail our program for unplanned start on automated peritoneal dialysis (APD) right after PD catheter implantation and summarizes our experiences with the program so far. Compared with planned start on PD after at least 2 weeks of break-in between PD catheter implantation and initiation of dialysis, unplanned start may be associated with a slight increased risk of mechanical complications but apparently no detrimental effect on mortality, peritonitis-free survival, or PD technique survival. In our opinion and experience, the risk of serious complications associated with the implantation and immediate use of a PD catheter is less than the risk of complications associated with unplanned start on HD with a temporary central venous catheter (CVC). Unplanned start on APD is a gentle, safe, and feasible alternative to unplanned start on HD with a temporary CVC that is also valid for the late-referred older patient with ESRD and urgent need for dialysis.
Handicap, une encyclopédie des savoirs
Authors: Herbin Régis 
Published: December 2015

Quelles que soient les particularités des utilisateurs, il y a nécessité de penser autrement l’accessibilité du cadre bâti et l’usage des espaces de vie. Le « droit de cité » des personnes en situation de handicap ou des aînés en perte d’autonomie exige la remise en cause des méthodes de production de l’espace construit. Cela concerne à la fois l’évaluation des besoins, la programmation, la conception et la réalisation d’espaces de vie pour tous. La dimension purement technique mérite d’être questionnée dans l’optique d’une « humanisation » de l’urbanisme et de l’architecture. C’est pourquoi la qualité d’usage met l’homme et ses besoins au cœur de tout projet, afin de remédier aux insuffisances de stratégies d’aménagement davantage centrées sur les préoccupations des aménageurs que sur la vie des usagers. Mais quelles sont les ressources et les limites du cadre réglementaire ? Qu’est-ce qui entrave la prise en compte de l’accessibilité dans l’urbanisme ? Où résident les enjeux de l’accessibilité et de la conception universelle ? En quoi les besoins des personnes en situation de handicap conduisent-ils au développement de la qualité d’usage pour tous ?
Handicap, une encyclopédie des savoirs
Authors: Gardou Charles , Laplantine François 
Published: December 2015

L’anthropologie, qui se définit moins par son objet que par un mode de connaissance singulier, révèle combien le handicap constitue un « événement » à dimension à la fois individuelle et collective. Modelé par le contexte et les manières collectives, diverses selon les époques et les cultures, de le considérer et le prendre en compte, ce « phénomène social total » ne peut s’appréhender qu’en situation. Dans une démarche qui allie distanciation et implication, l’anthropologie conduit donc à le des-essentialiser et à le re-culturaliser. Elle met aussi en lumière la continuité entre sensible, intelligible, culturel et social, comme entre singulier et universel. Elle montre que la question du handicap, où nichent les problématiques de l’identité et de l’altérité, des croyances, de l’échange et des modes de socialisation, éclaire les angles morts de la pensée sociale.
Handicap, une encyclopédie des savoirs
Authors: Gardou Charles , Plaisance Éric 
Published: December 2015

Les savoirs et pratiques pédagogiques sont grandement redevables aux précurseurs de l’éducation des enfants sourds et aveugles qui, au xviii e siècle, ont conçu, à partir du postulat d’éducabilité, des méthodes originales. De même, la tentative d’éducation de Victor, l’enfant sauvage, a inauguré l’éducation des enfants « arriérés » au début du xix e siècle. Cette expérience marque tout le siècle, jusqu’aux projets conçus pour les enfants des asiles, puis pour ceux que l’école considère comme « débiles ». Cependant, ces actions pionnières se sont, pour la plupart, heurtées à la persistance de préjugés stigmatisants et à l’extension, sans limites, de l’ « enseignement spécial », par exemple, avec les classes de perfectionnement dans les années 1960 et 1970. Qu’en est-il aujourd’hui d’une éducation voulue « inclusive », de la prise en compte des besoins éducatifs particuliers et de l’accessibilité pédagogique ?
Handicap, une encyclopédie des savoirs
Authors: Parisot Anne-Sophie 
Published: December 2015

Le droit est le reflet du regard porté par la société sur le handicap : parfois il révèle les retards du corps social, parfois il bouscule ses archaïsmes. Depuis un siècle, l’œuvre du législateur témoigne ainsi de lents mais incontestables progrès de la société en matière de reconnaissance des droits de la personne en situation de handicap. Au cours des quatre dernières décennies, de grands pas ont été franchis, notamment grâce à l’influence du droit international, à l’œuvre des juridictions européennes et à la pénétration du droit communautaire dans notre droit interne. Le juge français – et singulièrement le juge administratif – contribue aussi, par sa jurisprudence, à faire évoluer l’application des droits. En outre, un droit du handicap, encore embryonnaire aujourd’hui, pourrait prochainement émerger si, d’une part, certains freins inhérents à des cloisonnements juridiques ancrés dans notre culture législative et réglementaire sont levés, et si, d’autre part, les praticiens du droit comme les justiciables eux-mêmes prennent conscience de la nécessité d’obtenir une pleine effectivité de ces droits, désormais reconnus et proclamés.
1914-1920 : Comment les Polonais retrouveront-ils leur indépendance ?
Authors: Szymczak Damian 
Published: December 2015

La Grande Guerre est perçue, dans la mémoire historique des Polonais à travers le prisme particulier que fut la reconstitution, dans son issue, de la Pologne comme un État indépendant. L’article présente le parcours qui y menait, tracé tant par les circonstances que la guerre déterminait, que par les activités multiples, en partie contradictoires, en partie liées entreprises par les Polonais décidés à servir la cause de leur patrie. Tout en reconnaissant l’importance capitale de la date du novembre 1918, qui signifiait à la fois la fin de la guerre et la proclamation de la Pologne indépendante, l’auteur poursuit son récit jusqu’à l’automne 1920. C’est seulement alors qu’avec la victoire sur les Soviets, l’existence de l’État nouveau-né était assurée au bout du chemin qui, pour les Polonais, durait plus de six années, constituant deux étapes différentes et complémentaires.
Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes
Authors: Li Hongzhao , Wu Xun , Hou Sen , Malek Mouhannad , Kielkowska Anna , Noh Edward , Makondo Kennedy J. , Du Qiujiang , Wilkins John A. , Johnston James B. , Gibson Spencer B. , Lin Francis , Marshall Aaron J. 
Published: December 2015

Abstract
Cell migration is controlled by PI3Ks, which generate lipid messengers phosphatidylinositol-3,4,5-trisphosphate and phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and consequently recruit pleckstrin homology (PH) domain–containing signaling proteins. PI3K inhibition impairs migration of normal and transformed B cells, an effect thought to partly underlie the therapeutic efficacy of PI3K inhibitors in treatment of B cell malignancies such as chronic lymphocytic leukemia. Although a number of studies have implicated phosphatidylinositol-3,4,5-trisphosphate in cell migration, it remains unknown whether PI(3,4)P2 plays a distinct role. Using the PI(3,4)P2-specific phosphatase inositol polyphosphate 4-phosphatase, we investigate the impact of depleting PI(3,4)P2 on migration behavior of malignant B cells. We find that cells expressing wild-type, but not phosphatase dead, inositol polyphosphate 4-phosphatase show impaired SDF-induced PI(3,4)P2 responses and reduced migration in Transwell chamber assays. Moreover, PI(3,4)P2 depletion in primary chronic lymphocytic leukemia cells significantly impaired their migration capacity. PI(3,4)P2 depletion reduced both overall motility and migration directionality in the presence of a stable chemokine gradient. Within chemotaxing B cells, the PI(3,4)P2-binding cytoskeletal regulator lamellipodin (Lpd) was found to colocalize with PI(3,4)P2 on the plasma membrane via its PH domain. Overexpression and knockdown studies indicated that Lpd levels significantly impact migration capacity. Moreover, the ability of Lpd to promote directional migration of B cells in an SDF-1 gradient was dependent on its PI(3,4)P2-binding PH domain. These results demonstrate that PI(3,4)P2 plays a significant role in cell migration via binding to specific cytoskeletal regulators such as Lpd, and they suggest that impairment of PI(3,4)P2-dependent processes may contribute to the therapeutic efficacy of PI3K inhibitors in B cell malignancies.
Anti-CD20 Antibody with Multimerized Fc Domains: A Novel Strategy To Deplete B Cells and Augment Treatment of Autoimmune Disease
Authors: Zhang Xiaoyu , Olsen Henrik S. , Chen Shaodong , So Edward , Zhou Hua , Burch Erin , Mérigeon Emmanuel Y. , Block David S. , Strome Scott E. 
Published: December 2015

Abstract
We developed a fully recombinant anti-CD20 protein derived from cDNA encoding one Fab domain, two IgG1 Fc regions, the IgG2 hinge, and an isoleucine zipper. This protein, called GB4542, contained both the homodimer and higher-order multimers. Binding studies revealed that GB4542 preferentially bound CD20+ cells yet also recognized CD20−FcγR+ PBMC. In contrast, a control mAb containing the identical Fab region, GB4500, failed to bind CD20−FcγR+ PBMC. Consistent with these findings, interactions between GB4542 and the canonical FcγRs had substantially lower KD values than correlate interfaces between GB4500 and these receptors. At low concentrations, GB4542 showed enhanced Ab-dependent cellular cytotoxicity, Ab-dependent cellular phagocytosis, and complement-dependent cytotoxicity compared with GB4500. However, at higher concentrations, an Fc analog of GB4542 inhibited anti-CD20 mAb–mediated B cell clearance through direct blocking of both Fc–FcγR interactions and C1q deposition on target cells. Furthermore, the higher-order multimer fraction of GB4542 demonstrated greater binding avidity with the canonical FcγRs and was associated with inhibitory effects observed in Ab-dependent cellular phagocytosis and complement-dependent cytotoxicity assays. These data suggest that GB4542 might have utility in the treatment of autoimmune diseases by combining both mAb-mediated B cell depletion and multimerized Fc-mediated tolerogenic effects.
A Note on Quaternionic Hyperbolic Ideal Triangle Groups
Authors: Cao Wensheng , Huang Xiaolin 
Published: December 2015

AbstractIn this paper, the quaternionic hyperbolic ideal triangle groups are parametrized by a real one-parameter family {ϕ: s ∊ ℝ}. The indexing parameter s is the tangent of the quaternionic angular invariant of a triple of points in forming this ideal triangle. We show that if , then ϕs is not a discrete embedding, and if s , then ϕs is a discrete embedding.
Etude expérimentale du traitement par évaporation forcée des lixiviats des déchets ménagers. Cas de la ville de Kasbah Tadla
Authors: Benyoucef F. , El Ghmari A. , Ouatmane A. 
Published: December 2015

The aim of our work is the development of an evaporation technique for the treatment of leachate from household waste in the city of Kasba Tadla to avoid rejection permanently in nature. taking into account the characteristics of the selected site which has a warm climate with temperatures that exceed 50 °C during the summer period we favored a forced evaporation processing mode. several models have been tested, the alternatives given on the position of the evaporation pans relative to the ground, coverage evaporation pans by glass plates and their angle of inclination and the presence or absence of systems agitation and ventilation. The tests were used to develop a final evaporation model forced with glass plates inclined with a stirring system of leachate. forced evaporation of leachate testing have helped reduce the time of evaporation of leachate by 50% approximately relative to natural evaporation and 30% compared to evaporation with plates of horizontal glass. the power evaporating of this technique from a value of 0,37 mm/day to reach a value of 1,5 mm/day during the winter period. the model developed shows evaporation performance and effectiveness for the treatment of leachate so it stands out as alterative techniques for the treatment of leachate.
L’objectif de ce travail est le développement d’une technique d’évaporation pour le traitement des lixiviats de la décharge de la ville de Kasba Tadla au Maroc. du fait des caractéristiques du site qui présente un climat chaud avec des températures qui dépassent 50 °c pendant la période d’été, un mode de traitement par évaporation forcée a été étudié. les paramètres étudies sont la position des bacs d’évaporation par rapport au sol, la couverture des bacs d’évaporation à l’aide de plaques vitrées, l’angle d’inclinaison des plaques et la présence ou non des systèmes d’agitation et de ventilation. les essais ont permis de sélectionner un modelé d’évaporation forcée avec des plaques inclinées et un système d’agitation du lixiviat. le système d’évaporation forcée développe a permis de réduire le temps d’évaporation des lixiviats d’environ 50 % par rapport à une évaporation naturelle et de 30 % par rapport à une évaporation avec des plaques horizontales. il a également permis d’augmenter la vitesse d’évaporation de 0,37 mm/j à 1,5 mm/j pendant la période hivernale. les performances d’évaporation obtenues permettent ainsi de valider le système comme technique altérative pour le traitement des lixiviats.
Clinical Decision Support and Palivizumab
Authors: Hogan A. , Michel J. , Localio A.R. , Karavite D. , Song L. , Ramos M.J. , Fiks A.G. , Lorch S. , Grundmeier R.W. , Utidjian L.H. 
Published: December 2015

SummaryBackground and Objectives: Palivizumab can reduce hospitalizations due to respiratory syncytial virus (RSV), but many eligible infants fail to receive the full 5-dose series. The efficacy of clinical decision support (CDS) in fostering palivizumab receipt has not been studied. We sought a comprehensive solution for identifying eligible patients and addressing barriers to palivizumab administration.Methods: We developed workflow and CDS tools targeting patient identification and palivizumab administration. We randomized 10 practices to receive palivizumab-focused CDS and 10 to receive comprehensive CDS for premature infants in a 3-year longitudinal cluster-randomized trial with 2 baseline and 1 intervention RSV seasons.Results: There were 356 children eligible to receive palivizumab, with 194 in the palivizumab-focused group and 162 in the comprehensive CDS group. The proportion of doses administered to children in the palivizumab-focused intervention group increased from 68.4% and 65.5% in the two baseline seasons to 84.7% in the intervention season. In the comprehensive intervention group, proportions of doses administered declined during the baseline seasons (from 71.9% to 62.4%) with partial recovery to 67.9% during the intervention season. The palivizumab-focused group improved by 19.2 percentage points in the intervention season compared to the prior baseline season (p < 0.001), while the comprehensive intervention group only improved 5.5 percentage points (p = 0.288). The difference in change between study groups was significant (p = 0.05).Conclusions: Workflow and CDS tools integrated in an EHR may increase the administration of palivizumab. The support focused on palivizumab, rather than comprehensive intervention, was more effective at improving palivizumab administration.
A Preliminary internet survey of pet rabbit owners’ characteristics
Authors: Oxley J.A. , Previti A. , Alibrandi A. , Briefer E.F. , Passantino A. 
Published: December 2015

<p>This study aimed to conduct a preliminary survey to investigate basic ownership factors, frequency of microchipping and insurance and views of pet rabbit owners n these areas and general rabbit management. More specifically, we aimed to investigate whether owners possess insurance, whether their rabbits are microchipped, and owners’ views on the recommendations relating to rabbits (e.g. recommended enclosure sizes) and the law. A questionnaire was designed and promulgated through social media sites and rabbit forums. A total of 1183 responses were received. Just over 29% of respondents sourced their rabbits through rescue centres. 73.9% (867/1174) of owners stated that they had no pet insurance for their rabbits. Concerning microchips, 78.3% (919/1173) of rabbits were not microchipped, while 21.7% (254/1173) were. This preliminary study found that the majority of individuals are of the opinion that the relevant law is insufficiently publicised. A more detailed study would be beneficial to investigate and provide further insight into rabbit owners and their views and concerns for rabbits. The results of such a study could help formulate rabbit-related information and guidelines which in turn could have a direct impact on pet rabbit welfare.</p>
Determination of enzyme activity in rabbit seminal plasma and its relationship with quality semen parameters
Authors: Viudes de Castro M.P. , Casares-Crespo L. , Monserrat-Martínez A. , Vicente J.S. 
Published: December 2015

<p>The objective of this study was to determine rabbit seminal plasma enzyme activity. Furthermore, correlations between semen parameters and enzyme activity and male age were examined. The study was performed using 17 New Zealand White males from 5 to 9 mo old. Overall, 252 semen samples were collected from bucks from May to September. Semen characteristics were analysed and the seminal plasma was obtained by centrifugation. The activities of alanyl aminopeptidase (APN), aspartate transaminase (AST), alanine aminotransferase (ALT), γ-glutamyl transpeptidase (GGT), lactate dehydrogenase (LDH) and alkaline phosphatase (ALKP) in the seminal plasma fluid were measured. Significant differences between males were found in APN, GGT, LDH, ALKP and ALT activities (P&lt;0.05). No significant differences between enzyme activity and male age were found. We also observed significant positive correlations between male age and sperm concentration (r=0.26), progressive motility (r=0.17) and amplitude of lateral head displacement (r=0.21), and negative ones between male age and average path velocity (r=–0.56), velocity of the sperm head along its actual curvilinear path (r=–0.61), straight line velocity (r=–0.50), linearity index (r=–0.13), and cytoplasmic droplet (r=–0.33). Furthermore, a significant negative correlation between APN activity and the status of the acrosome (r=–0.20) and significant positive correlations between APN activity and the sperm abnormalities (r=0.21), GGT activity and sperm concentration (r=0.34) and the status of the acrosome (r=0.31), and ALKP activity and sperm concentration were observed (r=0.41). In our study, APN and GGT seem to be the most predictive enzymes for rabbit semen quality.</p>
Reattachment of Fractured Mandibular Incisor using Fiber-reinforced Post in a 12-year-old Patient: A 3-year Follow-up
Authors: Karthikeyani Shanmugasundaram , Thirumurthy Velliangattur Ramasamy , Bindhoo Yuvaraja 
Published: December 2015

ABSTRACT
The incidence of coronal fractures from traumatic injuries is high in school children and causes serious functional, esthetic and psychological problems. Dentists are confronted on a regular basis with their management. Reattachment of a fractured fragment, though not a new technique, is gaining interest as a treatment option. This is due to its advantages over other techniques and advancements in adhesive dentistry. This manuscript presents a 3-year follow-up of a case of complicated permanent mandibular central incisor fracture (no cases reported in literature), that was successfully treated by fragment reattachment using a fiber-reinforced post and discusses the factors affecting the success of reattachment technique.

How to cite this article
Karthikeyani S, Thirumurthy VR, Bindhoo Y. Reattachment of Fractured Mandibular Incisor using Fiber-reinforced Post in a 12-year-old Patient: A 3-year Follow-up. Int J Prosthodont Restor Dent 2015;5(3):86-89.
Effect of Neem containing Toothpaste on Plaque and Gingivitis—A Randomized Double Blind Clinical Trial
Authors: Supreetha S , Abhishek KN , Khan S Nubesh , Chaithanya KH , Abdul Nishad 
Published: December 2015

ABSTRACT

Aim
The present study was designed to assess the effect of toothpaste containing neem on plaque and gingivitis.

Materials and methods
Randomized, double blind clinical trial was designed. Thirty first year dental students volunteered to participate in the study. Neem containing tooth paste was used as an intervention. Clinical examination was carried out using Silness and Loe plaque index (PI) and Loe and Silness gingival index (GI). Independent t-test and paired t-test was used for the intergroup and the intragroup comparison.

Results
Out of 30 participants, 22 (73.3%) were females and eight (26.7%) were males. A statistically significant difference was found between the test and control group after intervention with respect to the PI and GI.

Conclusion
Neem containing toothpaste can be used as an adjunct for maintenance of oral hygiene.

Clinical significance
Regular brushing with neem toothpaste might act as an adjunct to maintenance of good oral hygiene, and thus improve oral health.

How to cite this article
Abhishek KN, Supreetha S, Sam G, Khan SN, Chaithanya KH, Abdul N. Effect of Neem containing Toothpaste on Plaque and Gingivitis—A Randomized Double Blind Clinical Trial. J Contemp Dent Pract 2015;16(11):880-883.
Minderjarige slachtoffers in herstelbemiddeling: positie en ervaringen
Authors: Renders Eline , Vanfraechem Inge 
Published: December 2015

Young victims in victim-offender mediation: position and experiences
This article studies the position of young victims in restorative justice and mediation. First we study the literature, which shows that although young victims may have specific needs, their position within restorative justice remains underexposed. Therefore, we have set up a small explorative study in the beginning of 2015. Through nine interviews with young victims who have gone through a mediation process in Flanders, we sought to answer three central questions. The article discusses whether these victims were satisfied with the mediation process, whether they could have a say in the process and what the importance was of having support persons throughout the mediation process.We found that the participation of the parents does influence the mediation process, since the parents are the main support persons for the young victim. Other support people are seldom present in the process, although some victims wanted the school or a friend to participate. Most of the young victims found they had a say in the process, but the presence of the parents could be an impediment in that regard. Young victims interviewed were generally satisfied with the mediator and mediation process, but not always with the outcome of the mediation. Ensuring that these young victims really get a say in the process proved to be a point of attention for practice.