bluuebunny/crossref_metadata_2025_split huggingface dataset:
Olanzapine-Induced Weight Gain and Glycolipid Metabolism Aberrations
in First-Episode and Antipsychotic-Naïve Schizophrenia Patients: A
Longitudinal Study
Authors: Li Shen , Zheng Doudou , Wang Wanyao , Liu Nannan , Li Yanzhe , Lu Chenghao , Dong Yeqing , Wang Xinxu , Li Wei-Dong , Li Jie 
Published: September 2024

Objective:
Limited research has delved into the comprehensive impact of monotherapy on
weight and glycolipid metabolism in schizophrenia (SCZ) patients. Our study aims to longitudinally
investigate the multidimensional effects of olanzapine (OLA) monotherapy on weight and glycolipid
metabolism in first-episode and antipsychotic-naïve (FEAN) SCZ patients.

Methods:
A total of 74 FEAN-SCZ patients were recruited, as well as 58 sex- and age-matched
healthy controls. Eligible patients underwent a 4-week OLA treatment regimen, with weight assessments
conducted at baseline and week 4. Moreover, lipid profiles and fasting plasma glucose (FPG)
were measured at baseline and week 4. Insulin, leptin (LEP), and adiponectin (APN) levels were determined
using enzyme-linked immunosorbent assay (ELISA) kits.

Results:
At baseline, FEAN-SCZ patients showed elevated levels of insulin, low-density lipoprotein
(LDL), impaired insulin sensitivity, and reduced levels of APN compared to the healthy controls. Following
4-week OLA treatment, patients showed an increase in body mass index (BMI) of 0.96 kg/m2.
Additionally, FPG, quantitative insulin sensitivity check index (QUICKI), HOMA-insulin sensitivity
index (HOMA-ISI), and fasting plasma glucose to insulin ratio (G/I) displayed significant decreases,
while insulin, HOMA-IR, and LEP levels showed significant increases. Stepwise regression analysis
revealed that baseline FPG independently predicted the change in BMI after 4 weeks of OLA treatment.

Conclusion:
FEAN-SCZ patients exhibited pre-existing alterations in glucose homeostasis. After 4
weeks of OLA treatment, SCZ patients experienced significant weight gain, deteriorating insulin resistance,
and increased LEP levels. In addition, baseline FPG emerged as a predictor of BMI changes
after 4 weeks of OLA treatment.
Impact of Health Informatics Analyst Education on Job Role, Career Transition, and Skill Development: Survey Study
Authors: Lee Kye Hwa , Lee Jae Ho , Lee Yura , Lee Hyunna , Lee Ji Sung , Jang Hye Jeon , Lee Kun Hee , Han Jeong Hyun , Jang SuJung 
Published: September 2024

Abstract

Background
Professionals with expertise in health informatics play a crucial role in the digital health sector. Despite efforts to train experts in this field, the specific impact of such training, especially for individuals from diverse academic backgrounds, remains undetermined.

Objective
This study therefore aims to evaluate the effectiveness of an intensive health informatics training program on graduates with respect to their job roles, transitions, and competencies and to provide insights for curriculum design and future research.

Methods
A survey was conducted among 206 students who completed the Advanced Health Informatics Analyst program between 2018 and 2022. The questionnaire comprised four categories: (1) general information about the respondent, (2) changes before and after program completion, (3) the impact of the program on professional practice, and (4) continuing education requirements.

Results
The study received 161 (78.2%) responses from the 206 students. Graduates of the program had diverse academic backgrounds and consequently undertook various informatics tasks after their training. Most graduates (117/161, 72.7%) are now involved in tasks such as data preprocessing, visualizing results for better understanding, and report writing for data processing and analysis. Program participation significantly improved job performance (P=.03), especially for those with a master’s degree or higher (odds ratio 2.74, 95% CI 1.08‐6.95) and those from regions other than Seoul or Gyeonggi-do (odds ratio 10.95, 95% CI 1.08‐6.95). A substantial number of respondents indicated that the training had a substantial influence on their career transitions, primarily by providing a better understanding of job roles and generating intrinsic interest in the field.

Conclusions
The integrated practical education program was effective in addressing the diverse needs of trainees from various fields, enhancing their capabilities, and preparing them for the evolving industry demands. This study emphasizes the value of providing specialized training in health informatics for graduates regardless of their discipline.
Engagement and Acceptability of Acceptance and Commitment Therapy in Daily Life in Early Psychosis: Secondary Findings From a Multicenter Randomized Controlled Trial
Authors: van Aubel Evelyne , Vaessen Thomas , Uyttebroek Lotte , Steinhart Henrietta , Beijer-Klippel Annelie , Batink Tim , van Winkel Ruud , de Haan Lieuwe , van der Gaag Mark , van Amelsvoort Thérèse , Marcelis Machteld , Schirmbeck Frederike , Reininghaus Ulrich , Myin-Germeys Inez 
Published: September 2024

Background
Acceptance and commitment therapy (ACT) is promising in the treatment of early psychosis. Augmenting face-to-face ACT with mobile health ecological momentary interventions may increase its treatment effects and empower clients to take treatment into their own hands.

Objective
This study aimed to investigate and predict treatment engagement with and acceptability of acceptance and commitment therapy in daily life (ACT-DL), a novel ecological momentary intervention for people with an ultrahigh risk state and a first episode of psychosis.

Methods
In the multicenter randomized controlled trial, 148 individuals with ultrahigh risk or first-episode psychosis aged 15-65 years were randomized to treatment as usual only (control) or to ACT-DL combined with treatment as usual (experimental), consisting of 8 face-to-face sessions augmented with an ACT-based smartphone app, delivering ACT skills and techniques in daily life. For individuals in the intervention arm, we collected data on treatment engagement with and acceptability of ACT-DL during and after the intervention. Predictors of treatment engagement and acceptability included baseline demographic, clinical, and functional outcomes.

Results
Participants who received ACT-DL in addition to treatment as usual (n=71) completed a mean of 6 (SD 3) sessions, with 59% (n=42) of participants completing all sessions. App engagement data (n=58) shows that, on a weekly basis, participants used the app 13 times and were compliant with 6 of 24 (25%) notifications. Distribution plots of debriefing scores (n=46) show that 85%-96% of participants reported usefulness on all acceptability items to at least some extent (scores ≥2; 1=no usefulness) and that 91% (n=42) of participants reported perceived burden by number and length of notifications (scores ≥2; 1=no burden). Multiple linear regression models were fitted to predict treatment engagement and acceptability. Ethnic minority backgrounds predicted lower notification response compliance (B=–4.37; P=.01), yet higher app usefulness (B=1.25; P=.049). Negative (B=–0.26; P=.01) and affective (B=0.14; P=.04) symptom severity predicted lower and higher ACT training usefulness, respectively. Being female (B=–1.03; P=.005) predicted lower usefulness of the ACT metaphor images on the app.

Conclusions
Our results corroborate good treatment engagement with and acceptability of ACT-DL in early psychosis. We provide recommendations for future intervention optimization.

Trial Registration
OMON NL46439.068.13; https://onderzoekmetmensen.nl/en/trial/24803
Dropout in a Longitudinal Survey of Amazon Mechanical Turk Workers With Low Back Pain: Observational Study
Authors: Qureshi Nabeel , Hays Ron D , Herman Patricia M 
Published: September 2024

Background
Surveys of internet panels such as Amazon’s Mechanical Turk (MTurk) are common in health research. Nonresponse in longitudinal studies can limit inferences about change over time.

Objective
This study aimed to (1) describe the patterns of survey responses and nonresponse among MTurk members with back pain, (2) identify factors associated with survey response over time, (3) assess the impact of nonresponse on sample characteristics, and (4) assess how well inverse probability weighting can account for differences in sample composition.

Methods
We surveyed adult MTurk workers who identified as having back pain. We report participation trends over 3 survey waves and use stepwise logistic regression to identify factors related to survey participation in successive waves.

Results
A total of 1678 adults participated in wave 1. Of those, 983 (59%) participated in wave 2 and 703 (42%) in wave 3. Participants who did not drop out took less time to complete previous surveys (30 min vs 35 min in wave 1, P<.001; 24 min vs 26 min in wave 2, P=.02) and reported having fewer health conditions (5.88 vs 6.6, P<.001). In multivariate models predicting responding at wave 2, lower odds of participation were associated with more time to complete the baseline survey (odds ratio [OR] 0.98, 95% CI 0.97-0.99), being Hispanic (compared with non-Hispanic, OR 0.69, 95% CI 0.49-0.96), having a bachelor’s degree as their terminal degree (compared with all other levels of education, OR 0.58, 95% CI 0.46-0.73), having more pain interference and intensity (OR 0.75, 95% CI 0.64-0.89), and having more health conditions. In contrast, older respondents (older than 45 years age compared with 18-24 years age) were more likely to respond to the wave 2 survey (OR 2.63 and 3.79, respectively) and those whose marital status was divorced (OR 1.81) and separated (OR 1.77) were also more likely to respond to the wave 2 survey. Weighted analysis showed slight differences in sample demographics and conditions and larger differences in pain assessments, particularly for those who responded to wave 2.

Conclusions
Longitudinal studies on MTurk have large, differential dropouts between waves. This study provided information about the individuals more likely to drop out over time, which can help researchers prepare for future surveys.
Implementation of Regular Lifestyle Counseling During Long-Term Follow-Up Care of Childhood Cancer Survivors: Monocentric Prospective Study
Authors: Richter Franziska , Kronziel Lea Louisa , König Inke , Langer Thorsten , Gebauer Judith 
Published: September 2024

Abstract

Background
Many childhood cancer survivors (CCS) develop treatment-related late effects, including an increased risk of obesity and metabolic syndrome. A healthy lifestyle can reduce the risk of associated comorbidities. Therefore, at-risk CCS could benefit from lifestyle counseling during regular long-term follow-up (LTFU).

Objective
We implemented a new form of care to decrease the long-term morbidity among CCS and to gain new insights into the lifestyle of those patients.

Methods
Over a 1-year study period, lifestyle counseling was integrated into LTFU care. Metabolic disorders, including hypercholesterolemia, diabetes mellitus, overweight or underweight, and low activity levels, were assessed as screening parameters for various risk groups. The perspectives of CCS, physicians, and sports scientists were compared to identify those with the highest needs. Each lifestyle counseling included general recommendations for physical activity, as well as an assessment of individual preferences for and barriers to the implementation of a healthy lifestyle. A follow-up appointment after 1 month was performed.

Results
Of the 155 CCS aged 18 to 63 years (n=100, 65% female and n=55, 35% male), 112 (72%) had an indication for lifestyle counseling, identified by physicians, sports scientists, or the CCS themselves. Metabolic disorders affected 45% (n=70) of these CCS, and 46% (n=72) did not meet recommended activity levels. A total of 120 (77%) CCS received lifestyle counseling, including 8 initially uninterested individuals who became open to recommendations. Those with intensive cancer treatment history showed the greatest need. A total of 65 (54%) CCS were advised to change their lifestyle in both areas (diet and exercise) while 51 (43%) CCS received recommendations for only exercise (n=43 CCS, 36%) or diet (n=8 CCS, 7%). A total of 4 (3%) CCS, although interested in counseling, received no advice, as they already met the recommendations. Follow-up revealed high adherence to recommendations and successful integration into daily lives. In total, 97% (n=150) of survivors indicated that the provision of lifestyle counseling during LTFU would be generally beneficial.

Conclusions
Incorporating specialized health care professionals such as sports scientists into survivorship care enhances the multidisciplinary approach of LTFU care. Promoting a healthy lifestyle by offering guideline-based lifestyle counseling is broadly accepted among CCS and may reduce long-term morbidity.
Pola konsumsi, konsumsi gula, dan status gizi pada wanita usia 35-55 tahun di Desa Batur, Kecamatan Getasan
Authors: Karwur Ferry Fredy , Prameshwari Deshinta , Rayanti Rosiana Eva 
Published: September 2024

Consumption pattern, sugar intake, and nutritional status of women aged 35-55 years in Batur Village, Getasan DistrictBackground: According to the Individual Food Consumption Survey of Central Java Province, residents consume an average of 22.9 grams of food from sugar, syrup, and confectionary groups daily, with sugar alone accounting for 20.2 grams. Sweet foods and beverages like sweet tea, tofu, and tempeh are commonly consumed in Central Java. Objective: The study assesses consumption patterns, sugar intake, and nutritional status (including anthropometric measurements, blood sugar levels, fasting blood sugar levels, uric acid levels, and blood pressure) of native Javanese women aged 35-55 in Batur, Getasan. Method: This quantitative research uses a descriptive approach with a sample of 106 women: 48 from Krangkeng village (lower), 22 from Kalitengah village (middle), and 36 from Tekelan village (upper). Research tools include SQ-FFQ, 24-hour food recall, anthropometric measurements, and biochemical and clinical examinations. Results: Food consumption frequency and quantity are highest in Krangkeng village. The average daily sugar consumption per person across all villages is 21.46±10.19 grams, equivalent to an average household purchase of 3,359.43±1,509.13 grams per month (about 3 kg per month per family). Types of sugar consumed include glucose (106.98±30.64 g/day), fructose (5.64±7.99 g/day), sucrose (102.18±23.75 g/day), and lactose (1.98±8.38 g/day). Average measurements for BMI, blood sugar, fasting blood sugar, uric acid, and blood pressure fall within normal ranges for women of this age group. Conclusion: Krangkeng village shows higher food consumption rates, likely due to more access to food supplies. Average daily sugar consumption remains below recommended levels (25 g/day). Overall, the women surveyed's nutritional status, biochemical, and clinical profiles are generally within normal range.
Olfactory Response of Diaphorina citri to Guava Leaves Powder
Authors: Poerwanto Mofit Eko , Solichah Chimayatus , Wicaksono Danar , Ulilalbab Azizah Ridha , Ajri Miftahul 
Published: September 2024

Citrus Vein Phloem Degeneration (CVPD) is transmitted by the insect vector Diaphorina citri is still a major obstacle to world citrus production. Vector handling still relies on chemical insecticides which are not environmentally friendly and less effective. This study was conducted to identify the ability of dried guava leaf extract in reducing the olfactory response of D. citri. Y-tube olfactory test was conducted to identify the repellency effect of a mixture of citrus leaf extract and guava (Psidium guajava) leaf extract at various leaf ages and in various proportions to vector and its predator (Menochilus sexmaculatus). The results showed that guava leaves had a repellent effect on D. citri, but not on M. sexmaculatus. The repellant effect was higher on young guava leaves than on medium and old ones. Red guava leaves have a highest repellant effect than white guava and non-seed guava leaves. Guava leaf extract is an alternative means to control D. citri. However, the types of compounds that function as repellants need to be studied further.
Reliability assessment of craniofacial and airway measurements: a comparative study between multidetector computed tomography and cone-beam computed tomography
Authors: Sun Jui-Sheng , Hung Min-Chih , Hsieh Chi-Yeh , Lin Shih-Ying , Tai Han-Cheng , Chang Jenny Zwei-Chieng 
Published: September 2024

ABSTRACT

Objectives
To compare the intra- and inter-examiner reliability of multidetector computed tomography (MDCT) and cone-beam computed tomography (CBCT) using Amira and Dolphin software analyses for craniofacial/airway measurements by six examiners.

Materials and Methods
Five adults and one dry skull with CBCT and MDCT scan files were duplicated and randomly numbered. Six orthodontic residents imported these files into two software programs, oriented the images, set thresholds, and performed 26 measurements. Intra- and inter-examiner reliabilities were determined by using intraclass correlation coefficient (ICC) and presented with scatterplots.

Results
Variables including anterior nasal width, posterior nasal width, frontomaxillary suture right-to-left, inner nasal contour point right-to-left, and minimum cross-sectional area in the oropharynx showed “moderate” to “substantial” intra- or inter-examiner agreement. Amira provided relatively reliable airway assessment, while Dolphin showed standard deviations 10 to 30 times larger for volumetric airway measurements. MDCT scans significantly reduced airway volume/area measurements compared to CBCT, except for intraoral airway volume.

Conclusions
Unreliable skeletal measurements and low reliability of Dolphin for airway analysis discourage using CT to quantitatively correlate changes in craniofacial structures with airway dimensions.
Grade IV gastric ulceration, pyloric aplasia, and an ectopic duodenal papilla in a 13-year-old Quarter Horse gelding evaluated for recurrent colic
Authors: Barton Charlotte K. , True Alex , Fenn Melissa , Thampi Parvathy , Watson Allison , Smanik Lauren E. 
Published: September 2024

Abstract

OBJECTIVE
The objective of this Case Report was to describe the clinical manifestation and postmortem findings of a horse evaluated for recurrent colic diagnosed with pyloric aplasia and an ectopic duodenal papilla.

ANIMAL
13-year-old Quarter Horse gelding.

CLINICAL PRESENTATION, PROGRESSION, AND PROCEDURES
The horse was presented to a referral center for signs of colic that were unresponsive to management on the farm. No abnormalities were noted on rectal palpation; however, upon passage of a nasogastric tube, 31 L of net gastric reflux was obtained. Gastroscopy noted grade IV squamous ulceration and moderate glandular ulceration, severe gastric dilatation, an abnormally positioned gastric outflow tract, and an ectopic duodenal papilla leaking bile-like fluid directly into the stomach.

TREATMENT AND OUTCOME
The horse was initially treated with gastroprotectants, promotility agents, and dietary modifications. Following treatment failure and repeated episodes of colic with increasing severity, the horse was euthanized and a necropsy performed. At necropsy, it was confirmed that the aboral aspect of the stomach formed a dilated pouch and continued directly into the proximal duodenum with no discernible pyloric sphincter. The area of the pylorus was delineated by a faint indentation. The ectopic duodenal papilla was traced to the liver.

CLINICAL RELEVANCE
Congenital gastric abnormalities, even in adult horses, should be considered as differential diagnoses when investigating horses presenting with a history of chronic colic. Neither pyloric aplasia nor an ectopic duodenal papilla have been described in the equine literature, and this Case Report raises awareness of the presence of such malformations and their manifestations.
Subclinical bacteriuria is nonprogressive but persistent in dogs four years of age or older recruited from a small animal primary care setting
Authors: Frey Erin , Rhea Sarah , Jacob Megan , Vaden Shelly , Kendall Allison , Bennett Katelyn , Johnson Brianna 
Published: September 2024

Abstract

OBJECTIVE
To evaluate clinical and microbial outcomes in dogs with untreated subclinical bacteriuria (SB) through longitudinal follow-up.

METHODS
Between February 24, 2022, and July 7, 2023, healthy client-owned dogs ≥ 4 years old with no evidence of lower urinary tract signs (LUTS) were recruited for a longitudinal, prospective study. Phase 1 dogs with SB were followed for 28 days to document comorbidities and microbiological findings (ie, urinalysis, urine culture, and fimH gene in Escherichia coli isolates). Phase 1 participants enrolled in phase 2 were followed for at least an additional 120 days.

RESULTS
The prevalence of SB was 11% (11 of 99), and all were female spayed. Of those with SB, 6 (55%) were followed for a median of 238 days; 91% (10 of 11) of phase 1 dogs and 67% (4 of 6) of phase 2 dogs had persistent bacteriuria, and 1 developed pyelonephritis 299 days after enrollment. Most dogs had E coli (8 of 11 [73%]), all of which contained the fimH gene. No change in antimicrobial susceptibility was noted during follow-up.

CONCLUSIONS
SB is generally nonprogressive and can persist for months after diagnosis. Patients with SB were more likely to be female, but no difference related to age, weight, or life stage was found. The presence of fimH, previously associated with biofilm, was negatively correlated with antimicrobial resistance.

CLINICAL RELEVANCE
For dogs with SB that are otherwise healthy, avoidance of systemic antimicrobials is warranted. For dogs with additional comorbidities, which might not be accompanied by, for example, pyelonephritis, or preclude the demonstration of LUTS, veterinarians should review the medical history and consider additional diagnostic testing.
Characterisation of wild red raspberry ecotypes in Northern Anatolia: Insights into sensory, biochemical and antioxidant properties
Authors: Eyduran Sadiye Peral , Ercisli Sezai , Ilhan Gulce , Ersoy Nilda , Ozkan Gursel , Bozhuyuk Mehmet Ramazan , Gecer Mustafa Kenan , Hasanbegovic Jasna , Assouguem Amine , Lahlali Rachid , Farah Abdellah , Ullah Riaz , Iqbal Zafar 
Published: September 2024

ABSTRACT
Red raspberries are among the most significant wild edible fruits (WEFs) in Türkiye, thriving in cold to warm temperate regions across the country. This study focuses on 11 wild red raspberry ecotypes sampled from the Northern Anatolia region, examining their sensory, biochemical and antioxidant properties. Sensory analysis was used to compare ecotypes based on aroma, taste and juiciness. Biochemical assessments included soluble solid content (SSC), vitamin C amount, organic acids, total anthocyanins (TA), total phenolic content (TPC), total flavonoid content and total antioxidant capacity. The Ferric Reducing Antioxidant Power (FRAP) assay measured antioxidant capacity. Despite similar growing conditions, significant variations were observed among ecotypes and across years. In the first year, fruit weights ranged from 1.04 g to 1.33 g, and in the second year, they ranged from 0.97 g to 1.27 g. Fruit chroma values ranged between 26.11 and 33.70 in 2021, and 23.17 and 30.19 in 2022. Vitamin C exhibited considerable variability, ranging from 29.3 mg · 100 g−1 to 44.4 mg · 100 g−1 across ecotypes and years. TPC, total anthocyanin content (TAC) and total flavonoid content ranged from 164 mg to 390 mg gallic acid equivalent (GAE) · 100 g−1, 17.3 mg to 33.2 mg cyanidin-3-glucoside equivalent · 100 g−1 and 10.3 mg to 17.6 mg quercetin equivalent (QE) · 100 g−1, respectively, in both years. Citric acid emerged as the dominant organic acid across all ecotypes. Notably, the ecotypes V-4, V-8, V-3 and V-10 showcased larger, more appealing fruits suitable for fresh consumption, whereas V-3 and V-5 presented sweeter fruits ideal for processing. Additionally, the ecotypes V-6, V-7 and V-11 displayed higher levels of health-promoting compounds, such as TPC and antioxidant capacity, suggesting their potential as functional foods and valuable sources of natural antioxidants in the future.