bluuebunny/crossref_metadata_2025_split huggingface dataset:
Structure II gas hydrates found below the bottom‐simulating reflector
Authors: Paganoni M. , Cartwright J. A. , Foschi M. , Shipp R. C. , Van Rensbergen P. 
Published: May 2016

AbstractGas hydrates are a major component in the organic carbon cycle. Their stability is controlled by temperature, pressure, water chemistry, and gas composition. The bottom‐simulating reflector (BSR) is the primary seismic indicator of the base of hydrate stability in continental margins. Here we use seismic, well log, and core data from the convergent margin offshore NW Borneo to demonstrate that the BSR does not always represent the base of hydrate stability and can instead approximate the boundary between structure I hydrates above and structure II hydrates below. At this location, gas hydrate saturation below the BSR is higher than above and a process of chemical fractionation of the migrating free gas is responsible for the structure I‐II transition. This research shows that in geological settings dominated by thermogenic gas migration, the hydrate stability zone may extend much deeper than suggested by the BSR.
Fast initial continuous current pulses versus return stroke pulses in tower‐initiated lightning
Authors: Azadifar Mohammad , Rachidi Farhad , Rubinstein Marcos , Rakov Vladimir A. , Paolone Mario , Pavanello Davide , Metz Stefan 
Published: May 2016

AbstractWe present a study focused on pulses superimposed on the initial continuous current of upward negative discharges. The study is based on experimental data consisting of correlated lightning current waveforms recorded at the instrumented Säntis Tower in Switzerland and electric fields recorded at a distance of 14.7 km from the tower. Two different types of pulses superimposed on the initial continuous current were identified: (1) M‐component‐type pulses, for which the microsecond‐scale electric field pulse occurs significantly earlier than the onset of the current pulse, and (2) fast pulses, for which the onset of the field matches that of the current pulse. We analyze the currents and fields associated with these fast pulses (return‐stroke type (RS‐type) initial continuous current (ICC) pulses) and compare their characteristics with those of return strokes. A total of nine flashes containing 44 RS‐type ICC pulses and 24 return strokes were analyzed. The median current peaks associated with RS‐type ICC pulses and return strokes are, respectively, 3.4 kA and 8 kA. The associated median E‐field peaks normalized to 100 km are 1.5 V/m and 4.4 V/m, respectively. On the other hand, the electric field peaks versus current peaks for the two data sets (RS‐type ICC pulses and return strokes) are characterized by very similar linear regression slopes, namely, 3.67 V/(m kA) for the ICC pulses and 3.77 V/(m kA) for the return strokes. Assuming the field‐current relation based on the transmission line model, we estimated the apparent speed of both the RS‐type ICC pulses and return strokes to be about 1.4 × 108 m/s. A strong linear correlation is observed between the E‐field risetime and the current risetime for the ICC pulses, similar to the relation observed between the E‐field risetime and current risetime for return strokes. The similarity of the RS‐type ICC pulses with return strokes suggests that these pulses are associated with the mixed mode of charge transfer to ground.
Disease Outcomes in Glucocorticosteroid‐Naive Patients With Systemic Lupus Erythematosus
Authors: Sheane Barry J. , Gladman Dafna D. , Su Jiandong , Urowitz Murray B. 
Published: May 2016

ObjectiveThe phenotype of patients who remain naive of glucocorticosteroids has not been described, and the type and rate of their damage accrual remains largely unknown. The objective of this study was to compare the type, amount, rate, and nature of organ damage accrual, mortality, and atherosclerotic comorbidities in glucocorticosteroid‐naive and glucocorticosteroid‐exposed patients with systemic lupus erythematosus (SLE).MethodsInception patients from the University of Toronto Lupus Clinic who had never taken glucocorticosteroids and had a minimum of 3 years of followup were compared to patients who received glucocorticosteroids within the first 6 months of SLE diagnosis and for at least 3 years. All patients had no damage at inception.ResultsA total of 86 glucocorticosteroid‐naive and 173 glucocorticosteroid‐exposed patients were included. There were more females and whites among the glucocorticosteroid‐naive patients, whereas the glucocorticosteroid‐exposed patients had higher Systemic Lupus Erythematosus Disease Activity Index 2000 scores on first examination. Overall mortality was higher in the glucocorticosteroid‐exposed group, but the deaths occurred late. There was no difference in the frequency of coronary artery disease overall or at each of the time points. Damage accrual was higher in glucocorticosteroid‐exposed patients overall and at 5 and 8 years. Individual damage items that were higher in glucocorticosteroid‐exposed patients included ocular (cataracts) and musculoskeletal (osteoporosis with fragility fractures, and osteonecrosis) components.ConclusionMortality is more frequent in patients taking glucocorticosteroids for at least the first 3 years of their lupus compared to patients who are glucocorticosteroid‐naive. In addition, patients taking glucocorticosteroids accumulate more damage by 5 years of disease, and damage tends to be glucocorticosteroid related, including cataracts and musculoskeletal components.
Changes in Ultrasonographic Vascularity Upon Initiation of Adalimumab Combination Therapy in Rheumatoid Arthritis Patients With an Inadequate Response to Methotrexate
Authors: Kaeley Gurjit S. , Nishio Midori J. , Goyal Janak R. , MacCarter Daryl K. , Wells Alvin F. , Chen Su , Kupper Hartmut , Kalabic Jasmina 
Published: May 2016

ObjectiveTo assess joint disease activity by ultrasound (US) in patients with rheumatoid arthritis (RA) initiating treatment with adalimumab (ADA) plus methotrexate (MTX).MethodsData for this post hoc analysis originated from the MUSICA trial (ClinicalTrials.gov identifier: NCT01185288), which evaluated the efficacy of initiating ADA (40 mg every other week) plus 7.5 or 20 mg/week MTX in 309 patients with RA with an inadequate response to MTX. Synovial vascularization over 24 weeks was assessed bilaterally at metacarpophalangeal joint 2 (MCP2), MCP3, MCP5, metatarsophalangeal joint 5, and the wrists by power Doppler US (PDUS). A semiquantitative 4‐grade scale was used. Disease activity was assessed using the Disease Activity Score in 28 joints using the C‐reactive protein level (DAS28‐CRP) and Simplified Disease Activity Index (SDAI). The correlation between continuous variables was assessed using Pearson's correlation coefficient.ResultsAfter 24 weeks of treatment with ADA plus MTX, rapid improvements in the mean synovial vascularity score were observed; the greatest improvements were in MCP2 (−0.5), MCP3 (−0.4), and the wrist (−0.4). At week 24, patients with the lowest DAS28‐CRP (<2.6) had the lowest mean 5‐joint and 3‐joint composite synovial vascularity scores. The 5‐joint and 3‐joint scores were strongly correlated (ρ > 0.9). Synovial vascularity scores correlated poorly with DAS28, swollen joint count in 66 joints (SJC66), SJC28, tender joint count in 68 joints (TJC68), TJC28, Clinical Disease Activity Index (CDAI), SDAI, physician's global assessment, patient's global assessment of pain, and disease duration (ρ < 0.2). Thirty‐two (70%) of 46 patients with a DAS28‐CRP of <2.6, and 11 (58%) of 19 patients with an SDAI indicating remission had at least 1 joint with a synovial vascularity score of ≥1.ConclusionPDUS detects changes in synovial vascularity in RA patients treated with ADA plus MTX, and residual synovial vascularity in patients in whom clinical disease control has been achieved.
A dual enzyme system composed of a polyester hydrolase and a carboxylesterase enhances the biocatalytic degradation of polyethylene terephthalate films
Authors: Barth Markus , Honak Annett , Oeser Thorsten , Wei Ren , Belisário‐Ferrari Matheus R. , Then Johannes , Schmidt Juliane , Zimmermann Wolfgang 
Published: May 2016

AbstractTfCut2 from Thermobifida fusca KW3 and the metagenome‐derived LC‐cutinase are bacterial polyester hydrolases capable of efficiently degrading polyethylene terephthalate (PET) films. Since the enzymatic PET hydrolysis is inhibited by the degradation intermediate mono‐(2‐hydroxyethyl) terephthalate (MHET), a dual enzyme system consisting of a polyester hydrolase and the immobilized carboxylesterase TfCa from Thermobifida fusca KW3 was employed for the hydrolysis of PET films at 60°C. HPLC analysis of the reaction products obtained after 24 h of hydrolysis showed an increased amount of soluble products with a lower proportion of MHET in the presence of the immobilized TfCa. The results indicated a continuous hydrolysis of the inhibitory MHET by the immobilized TfCa and demonstrated its advantage as a second biocatalyst in combination with a polyester hydrolase for an efficient degradation oft PET films. The dual enzyme system with LC‐cutinase produced a 2.4‐fold higher amount of degradation products compared to TfCut2 after a reaction time of 24 h confirming the superior activity of his polyester hydrolase against PET films.
Improved production of N‐acetylglucosamine in Saccharomyces cerevisiae by reducing glycolytic flux
Authors: Lee Sang‐Woo , Oh Min‐Kyu 
Published: May 2016

ABSTRACTGlucosamine and its derivatives are utilized in the food and biomedical industries. However, current production relies on hydrolysis of natural sources, making it difficult to maintain quality and eliminate allergenic risk. Therefore, microbial production with aid of metabolic engineering is required. We previously demonstrated production of N‐acetylglucosamine (GlcNAc) in Saccharomyces cerevisiae by overexpressing an allosteric regulation‐free Gfa1p mutant and the haloacid dehalogenase‐like phosphatase YqaB. In this study, we further improved GlcNAc production by reducing glycolytic flux. Eukaryotic phosphofructokinase 1 (PFK‐1) is allosterically activated by fructose 2,6‐bisphosphate (F26BP). Disruption of PFK‐2, which synthesizes F26BP, resulted in a slight decrease of GlcNAc production and no significant change of glucose consumption and ethanol production. However, when galactose was used as a sole carbon source to the strain without PFK‐2, GlcNAc production was significantly increased and ethanol production was reduced, suggesting that further reduction of glycolytic flux can be used to further improve GlcNAc production. The methodology used in this study can be applied to improve production of carbohydrate derivatives in S. cerevisiae. Biotechnol. Bioeng. Biotechnol. Bioeng. 2016;113: 2524–2528. © 2016 Wiley Periodicals, Inc.
Metabolic engineering of Escherichia coli to produce 2′‐fucosyllactose via salvage pathway of guanosine 5′‐diphosphate (GDP)‐l‐fucose
Authors: Chin Young‐Wook , Seo Nari , Kim Jae‐Han , Seo Jin‐Ho 
Published: May 2016

ABSTRACT2′‐Fucosyllactose (2‐FL) is one of the key oligosaccharides in human milk. In the present study, the salvage guanosine 5′‐diphosphate (GDP)‐l‐fucose biosynthetic pathway from fucose was employed in engineered Escherichia coli BL21star(DE3) for efficient production of 2‐FL. Introduction of the fkp gene coding for fucokinase/GDP‐l‐fucose pyrophosphorylase (Fkp) from Bacteroides fragilis and the fucT2 gene encoding α‐1,2‐fucosyltransferase from Helicobacter pylori allows the engineered E. coli to produce 2‐FL from fucose, lactose and glycerol. To enhance the lactose flux to 2‐FL production, the attenuated, and deleted mutants of β‐galactosidase were employed. Moreover, the 2‐FL yield and productivity were further improved by deletion of the fucI‐fucK gene cluster coding for fucose isomerase (FucI) and fuculose kinase (FucK). Finally, fed‐batch fermentation of engineered E. coli BL21star(DE3) deleting lacZ and fucI‐fucK, and expressing fkp and fucT2 resulted in 23.1 g/L of extracellular concentration of 2‐FL and 0.39 g/L/h productivity. Biotechnol. Bioeng. 2016;113: 2443–2452. © 2016 Wiley Periodicals, Inc.
Bioreduction of [Co(III)‐EDTA]− by Denitrifying Granular Sludge Biofilms
Authors: Reddy Gangidi Kiran Kumar , Nancharaiah Yarlagadda V. , Mohan Tulasi V. Krishna 
Published: May 2016

AbstractCobalt‐60 is a by‐product formed in the nuclear and defense‐related industries. Bioreduction of stable [Co(III)‐EDTA]− to the less stable [Co(II)‐EDTA]2− constitutes a bioremediation approach. Bioreduction of [Co(III)‐EDTA]− by a denitrifying microbial community was studied. Denitrifying granular sludge cultivated in a bioreactor exhibited efficient [Co(III)‐EDTA]− reduction. Fed‐batch experiments showed repeated reduction of [Co(III)‐EDTA]− without loss of microbial activity. Bioreduction of [Co(III)‐EDTA]− was accelerated in the presence of anthraquinone‐2,6‐disulfonate. Simultaneous reduction of both nitrate and [Co(III)‐EDTA]− was observed, but denitrification was delayed in the presence of [Co(III)‐EDTA]−. Microbial reduction in the presence of excess nitrate and acceleration by an electron shuttle has practical implications in cobalt bioremediation.
Phosphono Bisbenzguanidines as Irreversible Dipeptidomimetic Inhibitors and Activity‐Based Probes of Matriptase‐2
Authors: Häußler Daniela , Mangold Martin , Furtmann Norbert , Braune Annett , Blaut Michael , Bajorath Jürgen , Stirnberg Marit , Gütschow Michael 
Published: May 2016

AbstractMatriptase‐2, a type II transmembrane serine protease, plays a key role in human iron homeostasis. Inhibition of matriptase‐2 is considered as an attractive strategy for the treatment of iron‐overload diseases, such as hemochromatosis and β‐thalassemia. In the present study, synthetic routes to nine dipeptidomimetic inactivators were developed. Five active compounds (41–45) were identified and characterized kinetically as irreversible inhibitors of matriptase‐2. In addition to a phosphonate warhead, these dipeptides possess two benzguanidine moieties as arginine mimetics to provide affinity for matriptase‐2 by binding to the S1 and S3/S4 subpockets, respectively. This binding mode was strongly supported by covalent docking analysis. Compounds 41–45 were obtained as mixtures of two diastereomers and were therefore separated into the single epimers. Compound 45 A, with S configuration at the N‐terminal amino acid and R configuration at the phosphonate carbon atom, was the most potent matriptase‐2 inactivator with a rate constant of inactivation of 2790 m−1 s−1 and abolished the activity of membrane‐bound matriptase‐2 on the surface of intact cells. Based on the chemotyp of phosphono bisbenzguanidines, the design and synthesis of a fluorescent probe (51 A) by insertion of a coumarin label is described. The in‐gel fluorescence detection of matriptase‐2 was demonstrated by applying 51 A as the first activity‐based probe for this enzyme.
ChemInform Abstract: Chemistry of Sulfur Halides. Part 18. Crystal Structure of Tribromosulfonium(IV)‐hexafluoroantimonate(V), SBr+ 3SbF‐ 6.
Authors: MINKWITZ R. , LEKIES R. , PREUT H. 
Published: May 2016

AbstractThe title compound, prepared as shown in the scheme, crystallizes in space group P212121 with Z=4, The structure shows short contacts between S and F atoms forming a distorted ψ‐octahedral coordination around the S atom.
ChemInform Abstract: 17O and 27Al NMR Spectroscopic Investigations of Aluminum(III) Hydrolysis Products.
Authors: THOMPSON A. R. , KUNWAR A. C. , GUTOWSKY H. S. , OLDFIELD E. 
Published: May 2016

AbstractThe results of 17O and 27Al NMR spectra of the products of Al(III) hydrolysis by base show the combined use of solution and solid‐state NMR techniques to permit determination of nuclear quadrupolar coupling constants (e2qQ/h, in solution and solid state) for both the nuclei, and in suitable cases, measurements of rotational correlation times in solution.
ChemInform Abstract: Hydrogen Atom Abstraction from C‐H, P‐H, Si‐H, and Sn‐H Bonds by the Triplet Excited State of the Tetrakis(μ‐pyrophosphito)diplatinum(II) Tetraanion. Spectroscopic Observation of the Mixed‐Valence Hydride Complex Pt2(μ‐P2O5H2)4H4‐.
Authors: ROUNDHILL D. M. , ATHERTON S. J. , SHEN Z.‐P. 
Published: May 2016

AbstractThe Pt(II)Pt(III) hydride complex Pt2(μ‐P2O5H2)4H4‐ (I) can be generated by either pulse radiolysis of aqueous Pt2(μ‐P2O5H2)44‐ (II) at pH 4 in the presence of t‐BuOH or by pulsed‐laser photolysis (Nd‐YAG at 355 nm) or aqueous (II) with added i‐PrOH, H3PO3, or H3PO2.
ChemInform Abstract: Metal(II) Hexafluoroantimonates: Preparation and Characterization of MF2·2 SbF5 (M: Mg, Ni, Zn, Fe, Co, Cu, Cr, Ag, Cd, or Pb) and the X‐Ray Structure Determination of AgF2·2 SbF5.
Authors: GANTAR D. , LEBAN I. , FRLEC B. , HOLLOWAY J. H. 
Published: May 2016

AbstractThe title adducts are prepared according to the scheme (no yields given).
ChemInform Abstract: A New Low‐Temperature Route to Metal Polychalcogenides: Solid‐State Synthesis of K4Ti3S14, a Novel One‐Dimensional Compound.
Authors: SUNSHINE S. A. , KANG D. , IBERS J. A. 
Published: May 2016

AbstractThe title compound has been obtained from the reaction of Ti with K2S and S powder in a sealed silica tube at 375 °C (50 h).
ChemInform Abstract: Preparation, Structure, and Magnetic Properties of New Form of Chromium Orthoarsenate: β‐CrAsO4.
Authors: ATTFIELD J. P. , CHEETHAM A. K. , JOHNSON D. C. , TORARDI C. C. 
Published: May 2016

AbstractLight green needle‐shaped crystals of β‐CrAsO4 have been obtained at 700 °C under 3‐kbar hydrothermal pressure starting from Cr2O3 and a H3PO4 solution.
ChemInform Abstract: Pairwise Additivity in Exciton‐Coupled CD Curves of Multichromophoric Systems.
Authors: WIESLER W. T. , VAZQUEZ J. T. , NAKANISHI K. 
Published: May 2016

AbstractAll 24 permutational isomers of methyl α‐D‐glucopyranoside containing two acetates and two exciton chromophores (p‐bromobenzoate(s) and/or p‐methoxycinnamate(s)) such as (I) (six dicinnamates, six dibenzoates, and 12 monocinnamate monobenzoates) and 20 tri‐ and tetrachromophoric derivatives (all the six dibenzoate dicinnamates, the four monobenzoate tricinnamates and the four monocinnamate tribenzoates as well as the 6 trichromophoric monoacetates (II) and (III)) are prepared.
ChemInform Abstract: Long‐Distance Magnetic Exchange Between Chromium(III) Atoms Bridged by H3O‐ 2 Ligands.
Authors: ARDON M. , BINO A. , MICHELSEN K. , PEDERSEN E. 
Published: May 2016

AbstractThe magnetic susceptibilities of the known compound (I) and the complex (II), whose structure is established (space group P2/n, Z=2), are measured by the Faraday method at a field strength of 12000 Oe in the temp. range 1.7‐300 K. The data exhibit a decreasing magnetic moment at low temp., which is interpreted in terms of magnetic saturation at 13kG combined with antiferromagnetic coupling.
ChemInform Abstract: Electrochemical Formation of an Organic Thin Film by Disruption of Micelles.
Authors: HOSHINO K. , SAJI T. 
Published: May 2016

AbstractWhen aqueous solutions of 2.0 mmol of (11‐ferrocenylundecyl)trimethylammonium bromide as surfactant, 39 μmol of 1‐phenylazo‐2‐naphthol (PAN) to be deposited, and 0.2 mol Li2SO4 are electrolyzed with controlled potential using indium tin oxide (ITO) electrodes, thin films of PAN are deposited on the ITO electrodes because of an electrooxidative breakdown of the micelles of the surfactant which solubilized the PAN, which now is supersaturated.
ChemInform Abstract: Rate Enhancement of Biomimetic Polyene Cyclizations by a Cation‐Stabilizing Auxiliary.
Authors: JOHNSON W. S. , LINDELL S. D. , STEELE J. 
Published: May 2016

AbstractAn enormous rate acceleration is disclosed in the cyclization of the polyene (VIIb) (→ (VIIIb)) with an isobutenyl group at pro‐C‐8 as a cation‐stabilizing auxiliary group vs.
ChemInform Abstract: Catalytic Asymmetric Epoxidation and Kinetic Resolution: Modified Procedures Including in situ Derivatization.
Authors: GAO Y. , HANSON R. M. , KLUNDER J. M. , KO S. Y. , MASAMUNE H. , SHARPLESS K. B. 
Published: May 2016

AbstractThe use of 3 Å or 4 Å molecular sieves (ms) substantially increases the scope of the Ti(IV)‐catalyzed asym.
ChemInform Abstract: Convenient Preparation of 1,3‐Bis(2,3,4,5‐tetramethylcyclopentadienyl)propane: Use of 2,3,4,5‐Tetramethylcyclopent‐2‐enone Enolate as a Synthetic Equivalent for the Tetramethylcyclopentadienyl Anion.
Authors: MINTZ E. A. , PANDO J. C. , ZERVOS I. 
Published: May 2016

AbstractTreatment of the tetramethylcyclopentenone (I) with lithium diisopropylamide produces the enolate (II) which serves as a synthetic equivalent for the tetramethylcyclopentadienyl anion.
ChemInform Abstract: Regiospecific Oxidation of Methyl Groups in Dimethylanisoles.
Authors: HAUSER F. M. , ELLENBERGER S. R. 
Published: May 2016

AbstractThe dimethylanisoles (I) are regiospecifically oxidized at one methyl group using copper(II) sulfate and peroxodisulfate to yield the aldehydes (II).
ChemInform Abstract: (3.3)Orthocyclophanes with Facing Benzene and Naphthalene Rings.
Authors: MATAKA S. , TAKAHASHI K. , MIMURA T. , HIROTA T. , TAKUMA K. , KOBAYASHI H. , TASHIRO M. , IMADA K. , KUNIYOSHI M. 
Published: May 2016

AbstractThe unsymmetrically substituted bicyclic ketone (Vc) is synthesized as outlined in the reaction scheme.
ChemInform Abstract: Synthesis and X‐Ray Structural Analysis of a Five‐Membered Building Block.
Authors: KUNSTMANN R. , PAULUS E. F. 
Published: May 2016

AbstractIn connection with studies on the synthesis of prostaglandin analogues the 3a‐RS‐4‐RS‐5‐RS‐6a‐RS bicyclic acid (V) is prepared.
ChemInform Abstract: β‐Stannyl Enones as Radical Traps: A Very Direct Route to PGF2α.
Authors: KECK G. E. , BURNETT D. A. 
Published: May 2016

AbstractRadical‐induced reaction of the β‐stannyl enone (III) with the iodo acetals (VI) and (VIII) gives the enones (VII) and (IX) via a so‐called cyclization‐trapping sequence.
ChemInform Abstract: Palladium‐Catalyzed Coupling of Oxazol‐2‐yl‐ and 2‐Oxazolin‐2‐yltrimethylstannes with Aromatic Halides. A New Entry to 2‐Aryl‐ and 2‐Heteroaryloxazoles and ‐oxazolines.
Authors: DONDONI A. , FANTIN G. , FOGAGNOLO M. , MEDICI A. , PEDRINI P. 
Published: May 2016

Abstract4‐Methyloxazole (I) and 4,4‐dimethyl‐2‐oxazoline (VI) are converted to the 2‐trimethylstannyl derivatives (III) and (VII) by sequential treatment with butyllithium and trimethyltin chloride (II).
ChemInform Abstract: 2‐Substituted‐5‐Chloro/Nitrobenzophenones as Possible Anticonvulsants.
Authors: KULKARNI Y. D. , SHARMA R. , SHARMA V. L. , DUA P. R. 
Published: May 2016

AbstractThe 2‐amino or 2‐hydroxybenzophenones (I) are coupled with the arylthiocyanates (II) to produce the thiocarbamates or thioureas (III).
ChemInform Abstract: Reaction of an Iodonium Ylide with Methanesulfonyl Chloride.
Authors: HANEFELD W. , SPANGENBERG B. 
Published: May 2016

AbstractThe reaction of iodosylbenzene diacetate (II) with the 1,3‐dicarbonyl compounds (I) is investigated: the 1,3‐propanedione (Ia) and (II) produce the phenyliodonium ylide (III) which is converted to the 1,2,3‐ trione (IV) by means of ozonolysis.
ChemInform Abstract: Polyfunctionally Substituted Pyridines from Cyanoacetamide and Cyanoacetanilide.
Authors: MOHAREB R. M. , HABASHI A. , SHAMS H. Z. , FAHMY S. M. 
Published: May 2016

AbstractThe (diaminodicyanopyridyl)acetamides (III) are prepared by three different methods as outlined in the reaction scheme.
ChemInform Abstract: Studies on Quinoline and Phenothiazine. Preparation and Antimicrobial Activity of 2‐Morpholino‐4‐(8′‐oxyquinolino)‐6‐phenylurea‐s‐triazine and 1,3,7,9‐Tetrachloro‐10‐(acetylphenylurea)phenothiazine.
Authors: DESAI K. R. , KAPADIA S. K. 
Published: May 2016

AbstractThe quinoline derivatives (VII) mentioned in the title are prepared from cyanuric chloride (I) by consecutive substitution of the chlorine atoms for morpholine (II), 8‐hydroxyquinoline (IV) and the phenylureas (VI).