bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ethanol from Bagasse Obtained During Non-centrifuged Sugar Production. A Comprehensive Sustainability Analysis in the Colombian Context
Authors: Piedrahita-Rodríguez S. , Ortiz-Sánchez M. , Higuita Vásquez J. C. , Cardona Alzate C. A. 
Published: September 2024

AbstractThe production of biofuels is an alternative to reduce the impacts of the transformation of fossil fuel sources. In this work, the evaluation of ethanol production from the bagasse obtained during non-centrifuged sugar production (BNCS) to determine its sustainability in the Colombian context is proposed. Two pretreatments (i.e., dilute acid and alkaline) are proposed, followed by enzymatic saccharification to release glucose from cellulose. Both liquors rich in C6 sugars were followed by a fermentation stage with Saccharomyces cerevisiae, and the obtained ethanol concentration was measured. The process was simulated and evaluated to obtain metrics in technical, economic, environmental, and social terms. Also, an evaluation of the sustainability index of the process in the Colombian context was proposed. Diluted acid was the best processing pretreatment, reaching glucose and xylose concentrations of 15.13 g/L, and 12.15 g/L respectively, and a final ethanol concentration of 3.45 g/L. The technical analysis yielded results for Process Mass Intensity (PMI) of 38.14 and Renewable Material Index (RMI) of 5.09. The minimum process scale for economic feasibility (MPSEF) was 19.6 Ton/h. In this sense, the payback period and turnover ratio were 12 years and 35.01%, respectively. Values of 1.85 kg CO2 eq/kg ethanol for carbon footprint and 1.02 m3/kg ethanol for water depletion were also obtained. For the social analysis, the minimum-to-living wage ratio (M/L) was 1.03. Finally, the sustainability index was 75.19%, and the social and environmental values were the most influential aspects affecting the sustainability index. The results of this work allows a novelty vision related to the integral analysis of sustainability for one of Colombia’s native raw materials, and to propose viable solutions for its use, without threatening food security.
Graphical Abstract
Manganese Oxide Applications in Sulfonamides Electrochemical, Thermal and Optical Sensors: A Short Review
Authors: Mokaba Pheladi L. , Gazu Nolwazi T. , Makinita Marang L. , Mthombeni Nomcebo H. , Ntola Pinkie , Feleni Usisipho 
Published: September 2024

AbstractIn recent years, the development of highly sensitive and selective electrochemical sensors has been a pivotal area of research, driven by the growing demand for environmental monitoring and industrial process control. Among various materials investigated for sensor applications, manganese oxide (MnO2) nanoparticles have garnered significant attention due to their excellent electrochemical properties, environmental friendliness, and natural abundance. Critical analyses of the synthesis of MnO2 using different techniques such as hydrothermal method, chemical precipitation, and sol–gel process which allows for the fine-tuning of particle size and morphology while enhancing the electrochemical sensing capabilities have been reviewed. The review also provides a comprehensive overview of the recent advancement evaluation of manganese oxide-based electrodes for detecting sulfonamides and other analytes in water across diverse matrices. This paper sets the stage for a comprehensive exploration of the synthesis methods and application areas of MnO2 nanoparticles in electrochemical sensors, highlighting their role in advancing sensor technology and their impact on various sectors.
Graphical Abstract
Medical Toxicology vs. Emergency Medicine and Internal Medicine — Are We Really Full of Case Reports?
Authors: Hack Jason B. , O’Brien Kevin F. 
Published: September 2024

Abstract
Introduction
Case reports are perceived as having diminished value relative to other study designs. It has been said that medical toxicology (MT) is based largely upon case report literature and thought to be unique in this regard. We sought to quantify recent MT publication of case reports compared with top periodicals from emergency medicine (EM) and internal medicine (IM) journals.

Methods
A retrospective review examined 5 years of articles in 6 U.S.-based medical journals–MT (Journal of Medical Toxicology, Clinical Toxicology), EM (Annals of Emergency Medicine, Journal of Emergency Medicine), and IM (JAMA Internal Medicine, New England Journal of Medicine) was performed using on-line resources. Every article in each issue was categorized into Case report vs. Research and Analysis articles vs. Excluded. “Case report” was defined as one (or ≤ 5) individual patients, one patient’s data, etc. Total articles per issue were reported after removing Excluded items.

Results
Between 2018 and 2022, these 6 periodicals published 522 issues; with 2644 case reports; and 8246 total included articles. Comparison of MT case reports vs. EM revealed a significant difference and odds (Odds Ratio = 1.7, (95% CI: [1.49, 2.03], p < 0.001); MT compared with IM was not significantly different (Odds Ratio = 1.1, (95% CI: [0.96, 1.30], p = 0.150). The percent of case reports increased in the IM and EM journals compared with a relative decrease in the MT journals. Cumulative case report precents were consistently greater in EM and IM than in MT.

Conclusion
In the past 5 years, MT journals published fewer and had a declining trend of case reports compared with leading EM and IM journals. Future research is needed to determine the effect on MT practice resulting from the diminished body of case report literature.
Diallyl disulfide attenuates hydrogen peroxide-induced oxidative damage of ovine rumen epithelial cells through the nuclear factor erythroid-2 related factor 2 signaling pathway
Authors: Pang Rui , Zhang Qingyue , Wang Yuxin , Dong Xiaona , Huang Li , Tang Yingying , Ren Chunhuan , Xue Yanfeng , Zhang Zijun , Zhu Wen 
Published: September 2024

Abstract
This study investigated the impact of diallyl disulfide (DADS) on oxidative stress induced by hydrogen peroxide (H2O2) in ovine rumen epithelial cells (RECs). Initially, the effects of DADS were evaluated on cellular reactive oxygen species (ROS) levels, antioxidant capacity in RECs were estimated. Then, RNA-seq analysis was conducted in DADS-treated and untreated cells to analyze the differential gene expression, as well as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Finally, the effects of DADS on Kelch-like ECH associated protein 1/the nuclear factor erythroid 2-related factor 2 (Keap1/Nrf2) signaling pathway in RECs were evaluated. Results showed that DADS remarkably enhanced superoxide dismutase (SOD) activity and total antioxidant capacity (T-AOC) (P < 0.05) while reducing ROS and malonaldehyde production (P < 0.05) in H2O2-treated RECs. Transcriptomic analysis revealed that DADS might influence glutathione synthesis through cysteine and methionine metabolism, thereby affecting the transcription of genes involved in immunity and oxidative stress. The DADS treatment resulted in increased nuclear translocation of Nrf2 and upregulation of mRNA and protein levels of quinone oxidoreductase 1, heme oxygenase 1, and Nrf2. The Nrf2-specific inhibitor nullified the protective effects of DADS on malonaldehyde formation induced by H2O2 and decreased T-AOC and SOD activities. In conclusion, DADS demonstrated the ability to alleviate oxidative stress in RECs by promoting antioxidative capacity through the Keap1/Nrf2 signaling pathway.
Assessing the impact of discontinuation of formulary prior authorization on antibiotic prescribing
Authors: Zeggil Teagan , Nickonchuk Tony , Rennert-May Elissa , Rajakumar Irina 
Published: September 2024

Abstract

Objective:
To compare prescribing patterns of restricted antimicrobials before and after the removal of prior authorization and to develop a prospective audit and feedback program to mitigate the potential inappropriate prescribing of these antimicrobials.

Methods:
An interrupted time-series analysis assessing the trends in antibiotic use was conducted between May 2020 and February 2023 in large urban hospitals, where all ASP activities were discontinued in May 2022 and a pilot prospective audit and feedback (PAF) program was initiated in January 2023.

Results:
The collective change in restricted antibiotic utilization after the removal of prior authorization was trending towards increased utilization but was not statistically significant. With the PAF program, 9.8% of patients were identified by the antimicrobial stewardship pharmacists as requiring intervention. Within these patients, 19 different recommendations were made, with the most common being to narrow the therapeutic spectrum (47.4%). Stewardship interventions suggestions were accepted (full and partial) 69.2% of the time.

Conclusions:
Although there were some small statistically significant changes detected for a few antibiotics, there were no situations where those changes remained significant after appropriate controls were added to the analyses. As such, the intervention may not have had any statistically significant impact on DDDs of the studied antibiotics.
ATXN3: a multifunctional protein involved in the polyglutamine disease spinocerebellar ataxia type 3
Authors: Hernández-Carralero Esperanza , Quinet Grégoire , Freire Raimundo 
Published: September 2024

Abstract
ATXN3 is a ubiquitin hydrolase (or deubiquitinase, DUB), product of the ATXN3 gene, ubiquitously expressed in various cell types including peripheral and neuronal tissues and involved in several cellular pathways. Importantly, the expansion of the CAG trinucleotides within the ATXN3 gene leads to an expanded polyglutamine domain in the encoded protein, which has been associated with the onset of the spinocerebellar ataxia type 3, also known as Machado–Joseph disease, the most common dominantly inherited ataxia worldwide. ATXN3 has therefore been under intensive investigation for decades. In this review, we summarize the main functions of ATXN3 in proteostasis, DNA repair and transcriptional regulation, as well as the emerging role in regulating chromatin structure. The mentioned molecular functions of ATXN3 are also reviewed in the context of the pathological expanded form of ATXN3.
Regulating ESG Rating and Data Product Providers: Critically Examining EU Regulation through the Lens of Functional Regulatory Consistency
Authors: Chiu Iris H.-Y. 
Published: September 2024

Abstract
The expansion of EU regulatory governance in the financial sector since the end of the global financial crisis 2008 has given rise to the need to examine regulatory consistency in the volumes of financial regulation that may have cross-cutting implications. In this light, this article examines the effectiveness of the Regulation of ESG infomediaries through the lens of “functional regulatory consistency” with other infomediary regulations, for credit rating agencies and stock market benchmarks. It argues that this lens most aptly reveals the three key weaknesses of the regulatory regime for ESG infomediaries. These relate to sub-optimal coverage of scope, over-inclusiveness in the application of regulatory standards and under-inclusiveness where appropriate governance is not provided. the sub-optimal coverage of scope raises the question of whether ESG stock market index providers should indeed be regulated as ESG infomediaries or as stock market benchmarks more generally falling within the Benchmarks Regulation 2016. Over-inclusiveness and under-inclusiveness in the regulatory provision reflects blind spots in applying functional regulatory consistency, where it is inappropriate due to distinguishing features in business models, market structures or market relations.
The Journal of Law and Religion—Second Life
Authors: Failinger Marie A. 
Published: September 2024

Abstract
After its initial founding by the Council on Religion and Law at Harvard, the Journal of Law and Religion had its first life at Hamline University School of Law beginning in 1983. This essay is a history of its second life—from 1987/1988 to 2013—describing the vision and the people who pursued that vision through the journal in those years and some of the roundtables and symposia it published.
Using co-design to identify intervention components to address unhealthy dietary and activity behaviours in New Zealand South Asians
Authors: Parackal Sherly , Akhtar Sumera Saeed , Yadav Sivamanoj , Brown Rachel 
Published: September 2024

Abstract
There is an urgent need to develop sustainable and impactful interventions to mitigate the high risk of diet-related non-communicable diseases (diet-NCDs) in South Asians living in high-income countries. The current study using a co-design methodology aimed to identify community-led intervention components (solutions) to address barriers and enablers of disease-promoting dietary and physical activity behaviours in New Zealand South Asians. Data were collected from South Asian immigrants aged 25–59 years via three focus group discussions (n = 21) and 10 telephone or face-to-face interviews between 2018 and 2019. The thematic analysis resulted in identifying 22 barrier and enabler codes and 12 solution codes which were summarised under five themes. The key solutions (intervention components) to mitigate the identified target behaviours were providing recipes for using local vegetables in South Asian cuisine, information on the nutritional quality of frozen vegetables and canned lentils, simple home gardening techniques, the saturated fat content of dairy foods, interpreting nutrition labels, optimal portion sizes of foods, and framing low-fat messages positively. Similarly, group-based activities with peer support such as walking, cultural dancing and community sports like cricket, football, and tennis were the identified solutions to increase physical activity levels. The identified solutions for health promoting dietary habits and physical activity levels could be part of any targeted multicomponent health promoting programme to reduce the risk of diet-NCDs in South Asian immigrants.
Surface energy balance closure over melting snow and ice from in situ measurements on the Greenland ice sheet
Authors: van Tiggelen Maurice , Smeets Paul C. J. P. , Reijmer Carleen H. , van As Dirk , Box Jason E. , Fausto Robert S. , Khan Shfaqat Abbas , Rignot Eric , van den Broeke Michiel R. 
Published: September 2024

Abstract
Accurately quantifying all the components of the surface energy balance (SEB) is a prerequisite for the reliable estimation of surface melt and the surface mass balance over ice and snow. This study quantifies the SEB closure by comparing the energy available for surface melt, determined from continuous measurements of radiative fluxes and turbulent heat fluxes, to the surface ablation measured on the Greenland ice sheet between 2003 and 2023. We find that the measured daily energy available for surface melt exceeds the observed surface melt by on average 18 ± 30 W m−2 for snow and 12 ± 54 W m−2 for ice conditions (mean ± SD), which corresponds to 46 and 10% of the average energy available for surface melt, respectively. When the surface is not melting, the daily SEB is on average closed within 5 W m−2. Based on the inter-comparison of different ablation sensors and radiometers installed on different stations, and on the evaluation of modelled turbulent heat fluxes, we conclude that measurement uncertainties prevent a better daily to sub-daily SEB closure. These results highlight the need and challenges in obtaining accurate long-term in situ SEB observations for the proper evaluation of climate models and for the validation of remote sensing products.
The Brussels effect in Ankara: the case of climate policy
Authors: Korkmaz Tümer Elif , van Zeben Josephine 
Published: September 2024

Abstract
Turkey’s Europeanization process provides a particularly interesting case study of the extra-jurisdictional impact of European Union (EU) law, both through policy convergence and through the so-called Brussels effect. Formally, Turkey must adopt certain EU rules due to its status as an EU candidate country, but its candidacy process has been lengthy and uncertain, resulting in partial and uneven adoption of EU rules. Nevertheless, EU-style policymaking has persisted in various policy areas, including environmental and climate policy. This paper aims to analyze the convergence of climate change policies between the EU and Turkey by employing multidimensional scaling, a method that enables the visualization and examination of the connectivity and intensity of cooperation between states. For the period from 2007 to 2023, our comparative analysis demonstrates that policy divergence occurs when the EU’s share of Turkey’s total trade decreases and when political challenges are experienced. On the other hand, periods of policy convergence coincide with periods of increased trade volume and expanded trade opportunities. The results suggest that through its market size and regulatory capacity, the EU exerts soft power which forces Turkey to align its climate policies with the EU to protect and maintain its competitiveness in the European marketplace.
Successful diagnosis and treatment of Borrelia miyamotoi in a patient with joint and muscle pains, ME/CFS and cognitive dysfunction following tick bites: a case report
Authors: Teulières Louis , Jia Ying , Clokie Martha , Shan Jinyu 
Published: September 2024

Abstract

Introduction
Diagnosing Borrelia miyamotoi disease (BMD) presents challenges due to its overlap with Lyme disease (LD) symptoms and the lack of reliable laboratory diagnostics. This case study demonstrates the successful use of phage-based PCR (phb-PCR) in identifying B. miyamotoi in a patient with multiple tick bites. A 46-year-old female presented with joint and muscle pain, chronic fatigue, and cognitive impairment after being bitten by ticks in Europe. Standard diagnostic tests, including Enzyme-linked immunosorbent assay (ELISA), immunoblot for LD, and antibody tests for Bartonella, Anaplasma, and autoimmune conditions, all returned negative results. However, phb-PCR identified the presence of B. miyamotoi. The patient was treated with intravenous ceftriaxone, oral azithromycin, and intravenous vitamin and mineral therapy, resulting in significant improvement in symptoms, including reduced pain, improved cognitive function, and decreased fatigue. This case emphasises the importance of direct diagnostic methods like phb-PCR for accurately identifying BMD, especially when conventional serological tests fail. Clinicians should consider testing for B. miyamotoi in cases of complex tick-borne diseases for timely and effective management.
Beyond delinquency and drug use: Links of peer pressure to long-term adolescent psychosocial development
Authors: Allen Joseph P. , Costello Meghan A. , Stern Jessica A. , Bailey Natasha 
Published: September 2024

Abstract
This study examined the predictors and sequelae of exposure to peer pressure from close friends in adolescence. Adolescents (99 female; 85 male) were followed from age 13 to 24 utilizing peer, parent, and romantic partner reports and observational data. Participants who were exposed to high levels of peer pressure as teens were more likely to experience higher levels of coercive behavior from romantic partners (as reported by those partners), as well as lower levels of parent-reported functional independence. All findings held even after accounting for baseline levels of teen assertiveness. Adolescents at risk for increasing exposure to peer pressure were characterized by poor-quality parent and peer relationships, as well as baseline deficits in ability to assert autonomy. Results suggest that exposure to peer pressure, aside from its potential effects on deviant or risky behavior, may reflect a powerful threat to the autonomy development process as adolescents transition from parents to peers as primary sources of support and interaction.
Conservation and ‘the poor unfortunate foresters’: the regulation of the Ashdown Forest, Sussex 1870–1890
Authors: Short Brian 
Published: September 2024

Abstract
The twenty years surrounding the regulation of Ashdown Forest in 1885 reveal locally complex tensions and interactions. Designed to ensure the environmental protection of the Forest and to end internal dissent among those connected to it, regulation failed. Instead, protracted in-place conflict continued, as working families rejected new legislation which threatened their livelihoods. So the new body of conservators was faced with balancing such protection with the customary uses by commoners, with the working practices of ‘foresters’, with resurgent calls for small-scale farming, and with the ever-increasing residential numbers by the 1880s, many seeking ‘nature’ and ‘the primitive’, but also social tone. And increasingly, from beyond the locality, came the calls for environmental protection, especially from the newly formed Commons Preservation Society, urged on by newspaper articles recommending the fresh air and ‘natural’ beauty of Ashdown to townsfolk as a rural idyll or for moral improvement.
Experiences of mental health issues amongst dialectical behaviour therapists: an exploratory study
Authors: Essletzbichler Amy Gaglia , Sharp Rebecca , Swales Michaela 
Published: September 2024

Abstract
Little is known about dialectical behaviour therapists’ (DBT) own experiences of mental health issues or being experts by experience. Quantitative exploratory methodology surveyed DBT therapists about their own experiences of mental health issues. Questionnaires were varied and far-reaching including collection of data on demographics as well as mental health experiences and disclosures of difficulties, Adverse childhood experiences, quality of life, attitudes towards people with borderline personality disorder (BPD), and a measure of internalised stigma and stigma resistance for people who endorsed a formal mental health diagnosis. Ninety-four people responded, 92 of whom identified as a practising DBT; 80 endorsed a history of or current mental health difficulties. This exploratory research, based on responses from 94 DBT therapists, expands knowledge on the relevance of ‘wounded healer/impaired practitioner’ concepts for practitioners of DBT and raises issues related to consultation team and a duty of care towards DBT therapists. Low response rate makes it difficult to generalise these findings. Respondents were predominantly white, female, heterosexual therapists earning well above the median and mean incomes in the UK. Additionally, respondents were not asked to define the functions and modes of their DBT practice.

Key learning aims

(1)
Readers will learn about the treatment relationship within a DBT context.

(2)
Readers will learn about the concepts of wounded healer and impaired practitioner as well as the related issue of stigma.

(3)
Readers will learn about the experiences of mental health issues of 94 DBT therapists.