bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of retinal vein occlusion in the Australian National Eye Health Survey
Authors: Keel Stuart , Xie Jing , Foreman Joshua , van Wijngaarden Peter , Taylor Hugh R , Dirani Mohamed 
Published: July 2017

AbstractImportanceIn Australia, knowledge of the epidemiology of retinal vein occlusion remains scarce because of a paucity of recent population‐based data. The National Eye Health Survey (2015–2016) provides an up‐to‐date estimate of the prevalence of retinal vein occlusion in non‐Indigenous and Indigenous Australian adults.BackgroundTo determine the prevalence and associations of retinal vein occlusion in a national sample of Indigenous and non‐Indigenous Australian adults.DesignPopulation‐based cross‐sectional study.ParticipantsA total of 3098 non‐Indigenous Australians (aged 50–98 years) and 1738 Indigenous Australians (aged 40–92 years) living in 30 randomly selected sites, stratified by remoteness.MethodsRetinal vein occlusions were graded from retinal photographs using standardized protocols and recorded as central retinal vein occlusion or branch retinal vein occlusion.Main Outcome MeasurePrevalence of retinal vein occlusion.ResultsIn the non‐Indigenous population, the sampling weight adjusted prevalence of any retinal vein occlusion was 0.96% (95% confidence interval: 0.59, 1.6), with branch retinal vein occlusion observed in 0.72% (95% confidence interval: 0.41, 1.2) and central retinal vein occlusion in 0.24% (95% confidence interval: 0.13, 0.47). Any retinal vein occlusion was found in 0.91% (95% confidence interval: 0.47, 1.7) of Indigenous Australians aged 40 years and over, with branch retinal vein occlusion observed in 0.83% (95% confidence interval: 0.40, 1.7) and central retinal vein occlusion in 0.07% (95% confidence interval: 0.02, 0.32). Older age (odds ratio = 1.64 per 10 years, P = 0.006) and the presence of self‐reported diabetes (odds ratio = 3.24, P = 0.006) were associated with any retinal vein occlusion after multivariable adjustments. Retinal vein occlusion was attributed as the cause of monocular vision loss (<6/12) in seven (0.25%) non‐Indigenous and six (0.36%) Indigenous participants.Conclusions and relevanceThese data suggest that retinal vein occlusion is relatively uncommon in the non‐Indigenous Australians aged 50 years and over and Indigenous Australians aged 40 years and over. Similar to previous Australian and international reports, the prevalence of retinal vein occlusion rose sharply with age.
Accelerator‐free gloves as alternatives in cases of glove allergy in healthcare workers
Authors: Crepy Marie‐Noëlle , Lecuen Jérome , Ratour‐Bigot Carole , Stocks Jill , Bensefa‐Colas Lynda 
Published: July 2017

SummaryBackgroundAccelerators in rubber gloves constitute an important group of contact allergens, particularly in healthcare workers.ObjectivesTo assess the efficacy of accelerator‐free medical gloves in the secondary prevention of allergic contact dermatitis caused by rubber accelerators in healthcare workers.MethodsNine healthcare workers with hand eczema were advised to use accelerator‐free rubber gloves after a diagnosis of allergic contact dermatitis caused by rubber accelerators.ResultsSwitching from conventional medical single‐use gloves containing accelerators to accelerator‐free medical gloves led to improvement in all cases, and more than two‐thirds of the patients were completely free of symptoms.ConclusionThe use of accelerator‐free medical gloves can be an effective alternative in healthcare workers who are allergic to rubber accelerators.
Progesterone‐mediated angiogenic activity of endothelial progenitor cell and angiogenesis in traumatic brain injury rats were antagonized by progesterone receptor antagonist
Authors: Yu Peng , Li Shengjie , Zhang Zhifei , Wen Xiaolong , Quan Wei , Tian Qilong , Gao Chuang , Su Wanqiang , Zhang Jianning , Jiang Rongcai 
Published: July 2017

AbstractObjectivesProgesterone (P4) has the potential therapeutic effects for traumatic brain injury (TBI) whose recovery depended on the enhanced angiogenesis. Endothelial progenitor cell (EPC) plays an essential role in vascular biology. We previously demonstrated that P4 administration improved circulatingEPClevel and neurological recovery of rat withTBI. Here, we hypothesized that P4 augmented angiogenic potential ofEPCand the angiogenesis‐related neurorestoration afterTBIthrough classical progesterone receptor (PR).Materials and methodsEPCderived from rats were stimulated with graded concentrations (0, 10−10, 10−9, 5 × 10−9, 10−8, 10−7 mol/L) of P4 or 10−6 mol/L ulipristal acetate (UPA, aPRantagonist). Male rats were subjected to cortical impact injury and treated with (i)DMSO(dimethyl sulfoxide), (ii) P4 and (iii) P4 andUPA.ResultsIt showed that P4 improved the angiogenic potential ofEPC, including tube formation, adhesion, migration and vascular endothelial growth factor secretion, in a dose‐dependent fashion with the maximal effect achieved at 10−9 mol/L P4. High concentration (10−7 mol/L) of P4 impaired the angiogenic potential ofEPC. Notably, 10−6 mol/LUPAantagonized the stimulatory effects of 10−9 mol/L P4. After administrating P4, a significant improvement of neurological function and the restoration of the leaked blood‐brain barrier were observed as well as a reduction of the brain water content. Both vessel density and expression of occludin of vessels were increased. WhenUPAwas administered with P4, the neural restoration and angiogenesis were all reversed. Western blot showed that 10−9 mol/L P4 increased the content ofPRAandPRBofEPC, while 10−7 mol/L P4 reduced the content of bothPRisoforms, but there was no change found in theTBIrats.ConclusionsIt may suggest that P4‐mediated angiogenic activity ofEPCand angiogenesis inTBIrats were antagonized byPRantagonist.
Metabolic reprogramming by HIF‐1 activation enhances survivability of human adipose‐derived stem cells in ischaemic microenvironments
Authors: Chen Chang , Tang Qi , Zhang Yan , Dai Minjia , Jiang Yichen , Wang Hang , Yu Mei , Jing Wei , Tian Weidong 
Published: July 2017

AbstractObjectivesPoor cell survival severely limits the beneficial effect of adipose‐derived stem cell (ADSC)‐based therapy for disease treatment and tissue regeneration, which might be caused by the attenuated level of hypoxia‐inducible factor‐1 (HIF‐1) in these cells after having been cultured in 21% ambient oxygen in vitro for weeks. In this study, we explored the role of pre‐incubation in dimethyloxalylglycine (DMOG, HIF‐1 activator) in the survivability of human ADSCs in a simulated ischaemic microenvironment in vitro and in vivo. The underlying mechanism and angiogenesis were also studied.Materials and methodsSurvivability of ADSCs was determined in a simulated ischaemic model in vitro and a nude mouse model in vivo. Cell metabolism and angiogenesis were investigated by tube formation assay, flow cytometry, fluorescence staining and real‐time polymerase chain reaction (RT‐PCR) after DMOG treatment.ResultsThe results of the experimental groups showed significant enhancement of ADSC survivability in a simulated ischaemic microenvironment in vitro and transplanted model in vivo. Study of the underlying mechanisms suggested that the improved cell survival was regulated by HIF‐1‐induced metabolic reprogramming including decreased reactive oxygen species, increased intracellular pH, enhanced glucose uptake and increased glycogen synthesis. Tube formation assay revealed higher angiogenic ability in the DMOG‐treated group than that in control group.ConclusionsThe promotion of HIF‐1 level in ADSCs induced by DMOG preconditioning suggests a potential strategy for improving the outcome of cell therapy due to increased survival and angiogenic ability.
Down regulation of protective genes is associated with cellular and antibody‐mediated rejection
Authors: Lin‐Wang Hui Tzu , Cipullo Reginaldo , Dinkhuysen Jarbas J. , Finger Marco A. , Rossi João M. , Correia Edileide B. , Hirata Mário H. 
Published: July 2017

AbstractDespite advances in immunosuppressive therapy, rejection still remains the main obstacle to a successful transplant. This study aims to explore the gene expression profile of the rejection process in order to decrease the number of unnecessary endomyocardial biopsies in stable patients.MethodsA total of 300 formalin‐fixed and paraffin‐embedded (FFPE) endomyocardial biopsies sampled from 63 heart allograft recipients were included in this study. Acute cellular rejection (ACR) and antibody‐mediated rejection (AMR) were diagnosed by histological analysis and immunohistochemical C4d staining, respectively. Analysis of gene expression was performed by quantitative real‐time polymerase chain reaction. The samples were grouped according to the ISHLT rejection classification, aiming the statistical analysis.ResultsThere was a significant decrease in the HMOX1, AIF1, and CCL2 transcript over the post‐transplantation period in non‐rejection group (P<.001). Furthermore, the ADIPOR1, ADIPOR2, BCL2L1, and VEGFA protective genes were significantly downregulated in the ACR group (P<.05). ADIPOR2, BCL2L1, IL6, and NOS2 genes were also significantly downregulated in the AMR group than in the non‐rejection group (P<.05).ConclusionThe downregulations of the protective genes contribute to the allograft rejection, and the archived FFPE samples are useful for the gene expression analysis aiming the allograft rejection surveillance.
Below‐ground nematode herbivory of resistant soybean cultivars impairs the performances of an above‐ground caterpillar and its parasitoid
Authors: LI XIAOHONG , LI BAOPING , MENG LING 
Published: July 2017

1. Interactions between below‐ and above‐ground organisms have attracted interest in recent years, but less is known about the effect of root‐feeding nematodes on above‐ground trophic interactions between herbivores and their natural enemies.2. This study examined whether the presence of the soybean cyst root nematode Heterodera glycines influences the performance of the above‐ground leaf‐chewing tobacco cutworm Spodoptera litura on soybeans, Glycine max, and whether this in turn affects the success of its parasitoid, Meteorus pulchricornis. Using three soybean cultivars that varied in the level of constitutive resistance to the tobacco cutworm, the study determined whether feeding by the nematode altered the developmental and reproductive performances of the caterpillar and its parasitoid.3. Root feeding by the nematode slowed tobacco cutworm larval development time and reduced adult body weight. Root feeding by the nematode also had a negative effect on the caterpillar's parasitoid, by prolonging development time, decreasing adult body size and reducing fecundity. These effects increased in a linear trend and varied in magnitude depending on levels of soybean constitutive resistance.4. These findings demonstrate that root feeding by the nematode can prime soybean plants with negative impacts on their herbivore and its parasitoid, and that the impact may vary in magnitude depending on levels of soybean constitutive defence. The results emphasise the need to integrate soybean constitutive and root nematode‐induced defences for a better understanding of below‐ and above‐ground organism interactions, and to allow insights to be gained into the improvement of soybean integrated pest management programmes.
Determinants of influenza vaccination in older adults: A nationwide community‐based study in Taiwan
Authors: Chen Chang‐Hua , Wu Ming‐Shiang , Hsu Wen‐Yu , Chen Yu‐Min , Hsu Chih‐Cheng , Hsiung Chao A. , Wu I‐Chien 
Published: July 2017

AimsInfluenza vaccination (InVa) is an effective measure for preventing influenza infection, which is a major cause of morbidity and mortality in older adults. However, the determinants of InVa remain unclear.MethodsThe present study included 4756 adults aged 55 years and older who completed the baseline examination of the Healthy Aging Longitudinal Study in Taiwan. During the examination, each participant received assessments of InVa status. Comprehensive assessments of sociodemographic (age, sex, education level, marital status, living alone and occupation) and health‐related factors (chronic diseases, smoking status, alcohol intake, physical activities, cognitive status and physical performance) were also carried out. The InVa rate was defined as the number of participants who reported receiving free InVa divided by the total number of candidates for free InVa. Multinomial logistic regression analysis was applied to investigate the sociodemographic and health‐related determinants of InVa status.ResultsThe coverage rate of InVa was 44.8% (2130/4756). Older age (adjusted odds ratio [OR; >75 years vs <65 years] 7.72, 95% CI 6.26–9.52), multiple chronic diseases (OR [≥2 vs 0)] 1.31, 95% CI 1.10–1.65) and physical activity (OR [yes vs no] 1.43, 95% CI 1.23–1.64) were positively associated with receiving InVa. A current smoking status (OR 0.67, 95% CI 0.55–0.82) was negatively associated with receiving InVa.ConclusionsOlder adults who received InVa differed from non‐receivers in multiple sociodemographic and health‐related characteristics. These findings support continual efforts to improve the InVa coverage rate in vulnerable populations. Geriatr Gerontol Int 2017; 17: 2396–2402.
Debunking the myth of general consumer rejection of green genetic engineering: Empirical evidence from Germany
Authors: Butkowski Olivier K. , Pakseresht Ashkan , Lagerkvist Carl Johan , Bröring Stefanie 
Published: July 2017

AbstractThe emergence of a more sustainable economy in Europe was accompanied by a range of bio‐based products and technologies. As a prominent example, green genetic engineering opens up multiple options to increase agricultural production, but its public acceptance seems to vary by application area. Risk perception explains consumer acceptance of green genetic engineering, which is a necessary precondition for wider technology adoption. This study investigates risk perceptions for four major sources of risk: health related, environmental, socioeconomic and ethical. Data were collected in a laboratory experiment in Germany, with a total of 439 participants. A between‐subject design was employed. The four experimental treatment groups comprised two policy scenarios, namely one only permitting research and development and the other allowing full commercialization of genetically modified products, and two product end‐uses, bioenergy and food. The study shows significant end‐use differences in both the type of policy scenario and the risk dimension in question. In particular, health risks were generally perceived to be lower for bioenergy than food whenever full commercialization was pursued. Furthermore, full commercialization of genetically modified food prompted higher concerns about personal health, whereas use of crops for bioenergy production was broadly related to higher levels of socioeconomic risk. Finally, although the majority of consumers identified health risks as being most relevant, the consequences for the environment evoked the greatest degree of risk perception. In general, our findings lend support for the notion that the policy regime is the most important determinant for risk perception, followed by the type of risk dimension and level of trust in industry.
The relationship between professional communication competences and nursing performance of critical care nurses in South Korea
Authors: Song Hyo‐Suk , Choi JiYeon , Son Youn‐Jung 
Published: July 2017

AbstractBackgroundIneffective communication of critical care nurses can lead to higher levels of burnout and negatively affect quality of patient care and patient outcomes such as higher mortality.AimThe purpose of this study is to describe the relationship between professional communication competences and nursing performance of critical care nurses in South Korea.MethodThis cross‐sectional study collected data on 197 intensive care unit staff nurses in 3 tertiary academic medical centres in South Korea from July to November 2014.ResultsIn the hierarchical regression analysis, the professional communication competences were the only significant predictors of nursing performance after adjusting for sociodemographic characteristics. In addition, the greater professional communication competences of nurses were associated with being older and having a higher education level, more years of overall clinical and intensive care unit experience, and a higher monthly salary.ConclusionOur findings indicate that communication skills–related training should be included in the practical education to improve nursing performance for the quality of intensive care. Further research is needed to identify the comprehensive factors on professional communication competences of nurses in intensive care units.
Nurses' use of mobile instant messaging applications: A uses and gratifications perspective
Authors: Bautista John Robert , Lin Trisha T.C. 
Published: July 2017

AbstractAimTo explore how and why mobile instant messaging applications are used by Filipino nurses as part of their work.MethodsGuided by the uses and gratifications theory, in‐depth interviews with 20 staff nurses working in 9 hospitals (ie, 4 private and 5 public hospitals) in the Philippines were conducted in July 2015. Interview data were analysed through a phenomenological perspective to thematic analysis.ResultsResults show that mobile instant messaging applications such asFacebook MessengerandViberwere mostly used by staff nurses and these were accessed using their own smartphones. Thematic analysis indicates that they were used to meet staff nurses' need for information exchange, socialization, and catharsis. Moreover, user interactions vary depending on members within a chat group. For instance, communication via mobile instant messaging applications are much formal when superiors are included in a chat group.ConclusionIn general, the results show that mobile instant messaging applications are routinely used by Filipino staff nurses not only for clinical purposes (ie, information exchange) but also for non‐clinical purposes (ie, socialization and catharsis). This paper ends with several practical and theoretical implications including future research directions.
Clinical guidelines for male lower urinary tract symptoms and benign prostatic hyperplasia
Authors: Homma Yukio , Gotoh Momokazu , Kawauchi Akihiro , Kojima Yoshiyuki , Masumori Naoya , Nagai Atsushi , Saitoh Tadanori , Sakai Hideki , Takahashi Satoru , Ukimura Osamu , Yamanishi Tomonori , Yokoyama Osamu , Yoshida Masaki , Maeda Kenji 
Published: July 2017

AbstractThe present article is the abbreviated English translation of the Japanese guidelines for male lower urinary tract symptoms and benign prostatic hyperplasia updated as of the end of 2016. The target patients are men aged >50 years complaining of lower urinary tract symptoms, with or without benign prostatic hyperplasia, and the target readers are non‐urological general physicians and urologists. Mandatory assessment for general physicians is medical history, physical examination, urinalysis and measurement of serum prostate‐specific antigen. Additional mandatory assessment for urologists is symptoms and quality of life assessment by questionnaires, uroflowmetry, residual urine measurement, and prostate ultrasonography. Nocturia requires special attention, as it can result from nocturnal polyuria and/or sleep disturbance rather than lower urinary tract disorders. Functional lower urinary tract disorders with or without benign prostatic hyperplasia are primarily managed by conservative therapy and medications, such as α1‐blockers and phosphodiesterase‐type 5 inhibitors. Use of other medications or combination pharmacotherapy is to be reserved for urologists. 5α‐Reductase inhibitors and anticholinergics or β3 agonists are indicated for men with enlarged prostates and overactive bladder symptoms, respectively. Surgical intervention for bladder outlet obstruction is considered for persistent symptoms or benign prostatic hyperplasia‐related comorbidities. Surgical modalities should be optimized by the patient's characteristics, performance of equipment and the surgeon's experience.
Aspects of control and substance use among middle‐aged and older adults with bipolar disorder
Authors: Stalman Marissa N. , Canham Sarah L. , Mahmood Atiya , King David , O'Rourke Norm 
Published: July 2017

AbstractHigh prevalence rates of alcohol and substance use disorders have been reported among persons with bipolar disorder (BD). In the present study, we explored the daily experiences of middle‐aged and older adults living with BD who reported regular substance use and the ways in which participants expressed ‘control’ in relation to their use of alcohol and other substances. Semistructured, in‐depth interviews were conducted with 12 participants (nine women and three men), aged 36–57 years of age (mean = 49 years). Thematic analyses identified emergent themes and patterns in participants’ life histories. The theme of ‘control’ emerged as central to participants’ reports, and was organized into four categories: (i) substance use to control BD symptoms; (ii) substance use provides a sense of being in control; (iii) methods of controlled substance use; and (iv) not having control: overreliance on substances. Implications of the present study include the need for nurses to openly discuss the use of alcohol and other drugs with persons with BD, provide health information and screening, and determine whether persons with BD feel they have control over their substance use. Several lines of research with persons who have BD and use substances are suggested.
Safety and efficacy of dual‐wavelength laser (1064 + 595 nm) for treatment of non‐treated port‐wine stains
Authors: Wang T. , Chen D. , Yang J. , Ma G. , Yu W. , Lin X. 
Published: July 2017

AbstractBackgroundPatients with port‐wine stain (PWS) suffer physically and psychologically because of the high incidence (0.3%–0.5%) of the disease. Pulsed‐dye laser (PDL) at 595 nm is the gold standard of the treatment for PWS. Nevertheless, clinicians intend to determine whether the dual‐wavelength laser (DWL; 595‐nm PDL + 1064‐nm Nd:YAG) is an adequate choice in the treatment of non‐treated PWS. This study is the first prospective within‐patient controlled research seeking to investigate the safety and efficacy of DWL for the treatment of non‐treated PWS.MethodsA total of 61 patients with non‐treated flat facial PWS, who were treated using the Cynergy laser system in our clinic, were included in this study. Each PWS lesion was divided into two adjacent test treatment sites of similar size and colour. The two sites were randomly assigned to PDL or DWL treatment in a blinded manner of participants. In each case, two sets of treatment parameters were used: (i) 595‐nm PDL and (ii) 595‐nm PDL + 1064‐nm Nd:YAG. Both had a 10 mm spot size, an epidermal cooling system and 1‐s interpulse interval between two pulses. Clinical efficacy and safety outcomes were evaluated by visual assessment 2 months after treatment.ResultsComparison by visual evaluation suggests that the responses of non‐treated PWS to treatment by PDL and DWL were not significantly different. Moreover, three patients developed scarring after DWL treatment.ConclusionCompared with PDL, DWL exhibits a higher risk of potential scarring and has no advantage in efficacy of treating non‐treated PWS.