bluuebunny/crossref_metadata_2025_split huggingface dataset:
What factors are associated with reporting lacking interest in sex and how do these vary by gender? Findings from the third British national survey of sexual attitudes and lifestyles
Authors: Graham Cynthia A , Mercer Catherine H , Tanton Clare , Jones Kyle G , Johnson Anne M , Wellings Kaye , Mitchell Kirstin R 
Published: September 2017

ObjectivesTo investigate factors associated with reporting lacking interest in sex and how these vary by gender.SettingBritish general population.DesignComplex survey analyses of data collected for a cross-sectional probability sample survey, undertaken 2010–2012, specifically logistic regression to calculate age-adjusted OR (AOR) to identify associated factors.Participants4839 men and 6669 women aged 16–74 years who reported ≥1 sexual partner (opposite-sex or same-sex) in the past year for the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3).Main outcome measureLacking interest in sex for ≥3 months in the past year.ResultsOverall, 15.0% (13.9–16.2) of men and 34.2% (32.8–35.5) of women reported lacking interest in sex. This was associated with age and physical and mental health for both men and women, including self-reported general health and current depression. Lacking interest in sex was more prevalent among men and women reporting sexually transmitted infection diagnoses (ever), non-volitional sex (ever) and holding sexual attitudes related to normative expectations about sex. Some gender similarities in associated relationship and family-related factors were evident, including partner having had sexual difficulties in the last year (men: AOR 1.41 (1.07–1.86); women: AOR 1.60 (1.32–1.94)), not feeling emotionally close to partner during sex (men: 3.74 (1.76–7.93); women: 4.80 (2.99–7.69) and ease of talking about sex (men: 1.53 (1.23–1.90);women: 2.06 (1.77–2.39)). Among women only, lack of interest in sex was higher among those in a relationship of >1 year in duration and those not sharing the same level of interest (4.57 (3.87–5.38)) or preferences (2.91 (2.22–3.83)) with a partner.ConclusionsBoth gender similarities and differences were found in factors associated with lacking interest in sex, with the most marked differences in relation to some relationship variables. Findings highlight the need to assess, and if appropriate, treat lacking interest in sex in a holistic and relationship-specific way.
Fradkin–Shenker continuity and “instead-of-confinement” phase
Authors: Shifman M. , Yung A. 
Published: September 2017

In 1979, Fradkin and Shenker observed [Phys. Rev. D 19, 3682 (1979)] that if one considers a Yang–Mills theory fully Higgsed by virtue of scalar fields in the fundamental representation of the SU(N) gauge group there is no phase transition in passing from the Higgs regime (weak coupling) to the “QCD confinement” regime at strong coupling. The above two regimes are continuously connected. We combine this observations with lessons from supersymmetric gauge theories which show that the Higgs phase is continuously connected to what is called “instead-of-confinement” phase rather than the phase with quark confinement. In the “instead-of-confinement” phase monopoles are confined and play a role of “constituent” quarks inside hadrons. In contrast, the Seiberg–Witten phase of quark confinement is not analytically connected to the Higgs phase. We propose dedicated lattice studies of Yang–Mills theories with scalar quarks.
Comparison study of the pT distributions of the charged particles in p–Pb interactions at LHC energies
Authors: Ali Y. , Tabassam U. , Suleymanov M. , Bhatti A. S. 
Published: September 2017

Transverse momentum [Formula: see text] distributions of primary charged particles were compared to simulations using the Ultra Relativistic Quantum Molecular Dynamics (UrQMD) transport model and the HIJING 1.0 model in minimum bias p–Pb collisions at [Formula: see text] in the pseudorapidity [Formula: see text] regions: [Formula: see text], [Formula: see text] and [Formula: see text] and in the transverse momentum range [Formula: see text]. The simulated distributions were then compared with the ALICE data and it was observed that UrQMD predicts systematically higher yields than HIJING 1.0. Both codes cannot describe the experimental data in the range of [Formula: see text], though in the region of [Formula: see text] the model predictions are very close to the experimental results for particles with [Formula: see text], [Formula: see text]. The ratio of the yield at forward pseudorapidity to that at [Formula: see text] was also studied. It was observed that the predictions of the models depend on [Formula: see text]. In the experiment there is no essential difference of yields for particles from the intervals of [Formula: see text], [Formula: see text] and [Formula: see text]. The differences are significant for the models where the ratios are systematically less than 1. This means that the results are not connected to a medium effect but reflect the Cronin effect. We are led to conclude that the codes cannot take into account satisfactorily the leading effect due to the asymmetric p–Pb fragmentation.
Influence of biases in numerical magnitude allocation on human prosocial decision making
Authors: Arshad Qadeer , Nigmatullina Yuliya , Siddiqui Shuaib , Franka Mustafa , Mediratta Saniya , Ramachandaran Sanjeev , Lobo Rhannon , Malhotra Paresh A. , Roberts R. E. , Bronstein Adolfo M. 
Published: September 2017

Over the past decade neuroscientific research has attempted to probe the neurobiological underpinnings of human prosocial decision making. Such research has almost ubiquitously employed tasks such as the dictator game or similar variations (i.e., ultimatum game). Considering the explicit numerical nature of such tasks, it is surprising that the influence of numerical cognition on decision making during task performance remains unknown. While performing these tasks, participants typically tend to anchor on a 50:50 split that necessitates an explicit numerical judgement (i.e., number-pair bisection). Accordingly, we hypothesize that the decision-making process during the dictator game recruits overlapping cognitive processes to those known to be engaged during number-pair bisection. We observed that biases in numerical magnitude allocation correlated with the formulation of decisions during the dictator game. That is, intrinsic biases toward smaller numerical magnitudes were associated with the formulation of less favorable decisions, whereas biases toward larger magnitudes were associated with more favorable choices. We proceeded to corroborate this relationship by subliminally and systematically inducing biases in numerical magnitude toward either higher or lower numbers using a visuo-vestibular stimulation paradigm. Such subliminal alterations in numerical magnitude allocation led to proportional and corresponding changes to an individual’s decision making during the dictator game. Critically, no relationship was observed between neither intrinsic nor induced biases in numerical magnitude on decision making when assessed using a nonnumerical-based prosocial questionnaire. Our findings demonstrate numerical influences on decisions formulated during the dictator game and highlight the necessity to control for confounds associated with numerical cognition in human decision-making paradigms. NEW & NOTEWORTHY We demonstrate that intrinsic biases in numerical magnitude can directly predict the amount of money donated by an individual to an anonymous stranger during the dictator game. Furthermore, subliminally inducing perceptual biases in numerical-magnitude allocation can actively drive prosocial choices in the corresponding direction. Our findings provide evidence for numerical influences on decision making during performance of the dictator game. Accordingly, without the implementation of an adequate control for numerical influences, the dictator game and other tasks with an inherent numerical component (i.e., ultimatum game) should be employed with caution in the assessment of human behavior.
ANGPTL1 Interacts with Integrin α1β1 to Suppress HCC Angiogenesis and Metastasis by Inhibiting JAK2/STAT3 Signaling
Authors: Yan Qian , Jiang Lingxi , Liu Ming , Yu Dandan , Zhang Yu , Li Yan , Fang Shuo , Li Yan , Zhu Ying-Hui , Yuan Yun-Fei , Guan Xin-Yuan 
Published: September 2017

Abstract
Downregulation of tumor suppressor signaling plays an important role in the pathogenesis of hepatocellular carcinoma (HCC). Here, we report that downregulation of the angiopoietin-like protein ANGPTL1 is associated with vascular invasion, tumor thrombus, metastasis, and poor prognosis in HCC. Ectopic expression of ANGPTL1 in HCC cells effectively decreased their in vitro and in vivo tumorigenicity, cell motility, and angiogenesis. shRNA-mediated depletion of ANGPTL1 exerted opposing effects. ANGPTL1 promoted apoptosis via inhibition of the STAT3/Bcl-2–mediated antiapoptotic pathway and decreased cell migration and invasion via downregulation of transcription factors SNAIL and SLUG. Furthermore, ANGPTL1 inhibited angiogenesis by attenuating ERK and AKT signaling and interacted with integrin α1β1 receptor to suppress the downstream FAK/Src–JAK–STAT3 signaling pathway. Taken together, these results suggest ANGPTL1 as a prognostic biomarker and novel therapeutic agent in HCC. Cancer Res; 77(21); 5831–45. ©2017 AACR.
Biology and Etiology of Young-Onset Breast Cancers among Premenopausal African American Women: Results from the AMBER Consortium
Authors: Chollet-Hinton Lynn , Olshan Andrew F. , Nichols Hazel B. , Anders Carey K. , Lund Jennifer L. , Allott Emma H. , Bethea Traci N. , Hong Chi-Chen , Cohen Stephanie M. , Khoury Thaer , Zirpoli Gary R. , Borges Virginia F. , Rosenberg Lynn A. , Bandera Elisa V. , Ambrosone Christine B. , Palmer Julie R. , Troester Melissa A. 
Published: September 2017

AbstractBackground: African American (AA) women have higher incidence of aggressive, young-onset (&lt;40 years) breast cancers. Young- and older-onset disease may have distinct tumor biologies and etiologies; however, studies investigating age differences among AA women have been rare and generally underpowered.Methods: We examined tumor characteristics and breast cancer risk factors associated with premenopausal young (&lt;40) vs. older (≥40) AA women's breast cancer in the African American Breast Cancer Epidemiology and Risk Consortium (2,008 cases and 5,144 controls). Unconditional logistic regression models assessed heterogeneity of tumor biology and risk factor associations by age, overall, and by estrogen receptor status.Results: Premenopausal AA women &lt;40 years had higher frequency of poorer-prognosis tumor characteristics compared with older women, including negative estrogen and progesterone receptor status, triple-negative subtype, higher grade, higher stage, and larger tumors. Adiposity (i.e., waist-to-hip ratio) and family history of breast cancer were more strongly associated with young-onset disease [case–control OR = 1.46, 95% confidence interval (CI) = 1.04–2.05; OR = 3.10, 95% CI = 2.08–4.63, respectively] compared with older-onset disease (OR = 1.11, 95% CI = 0.91–1.35; OR = 1.57, 95% CI = 1.26–1.94). Breastfeeding showed a slight inverse risk association among young women (OR = 0.70, 95% CI = 0.43–1.16). Oral contraceptive use was associated with increased risk regardless of age. Considering various cutoff points for young age (&lt;40, &lt;45, &lt;50), age-related heterogeneity was greatest when &lt;40 was used.Conclusions: Among premenopausal AA women, diagnosis before age 40 is associated with more aggressive breast tumor biology and some etiologic differences.Impact: Modifiable risk factors including breastfeeding, adiposity, and oral contraceptive use may be important targets for mitigating harms of young-onset breast cancer. Cancer Epidemiol Biomarkers Prev; 26(12); 1722–9. ©2017 AACR.
Taxonomic revision of the tigrina Leopardus tigrinus (Schreber, 1775) species group (Carnivora, Felidae)
Authors: Nascimento Fabio Oliveira do , Feijó Anderson 
Published: September 2017

The tigrina Leopardus tigrinus (Schreber, 1775) is a small-sized Neotropical spotted cat found from northern Argentina and southern Brazil to Costa Rica. Four subspecies are traditionally recognized: L. t. tigrinus (Schreber, 1775) from northern Brazil, the Guianas and eastern Venezuela; L. t. pardinoides (Gray, 1867) from western Venezuela, Colombia, Ecuador and Peru; L. t. guttulus (Hensel, 1872) from southern Brazil, Paraguay and northern Argentina; and L. t. oncillus (Thomas, 1903) from Costa Rica. We studied external and craniodental morphology in quantitative and qualitative terms from 250 specimens in order to clarify the taxonomic status of tigrina. Based on the characters analyzed in this study, we recognize three diagnosable morphogroups, each with a distinct geographic distribution: northern/northwestern/west (samples from northern Brazil, the Guianas, Venezuela, Colombia, Ecuador, Peru, northwestern Argentina and Costa Rica), eastern (samples from northeastern and central Brazil), and southern (samples from southern Brazil, Paraguay and northeastern Argentina). Taking into account the morphologic evidence presented here, supported by biogeographic data and molecular studies available, we recognize three full species for tigrinas: L. tigrinus (including the putative subspecies L. t. pardinoides and L. t. oncillus as junior synonyms) for northern/northwestern/west group; L. emiliae (Thomas, 1914) for eastern group; and L. guttulus for southern group.
Percutaneous Coronary Intervention Versus Optimal Medical Therapy for Chronic Total Coronary Occlusion With Well‐Developed Collaterals
Authors: Choi Se Yeon , Choi Byoung Geol , Rha Seung‐Woon , Baek Man Jong , Ryu Yang Gi , Park Yoonjee , Byun Jae Kyeong , Shim Minsuk , Li Hu , Mashaly Ahmed , Jang Won Young , Kim Woohyeun , Choi Jah Yeon , Park Eun Jin , Na Jin Oh , Choi Cheol Ung , Lim Hong Euy , Kim Eung Ju , Park Chang Gyu , Seo Hong Seog , Oh Dong Joo 
Published: September 2017

Background

The impact of percutaneous coronary intervention (
PCI
) on chronic total occlusion in patients with well‐developed collaterals is not clear.

Methods and Results

A total of 640 chronic total occlusion patients with collateral flow grade ≥2 were divided into 2 groups; chronic total occlusion patients either treated with
PCI
(the
PCI
group; n=305) or optimal medical therapy (the optimal medical therapy group; n=335). To adjust for potential confounders, a propensity score matching analysis was performed. Major clinical outcomes were compared between the 2 groups up to 5 years. In the entire population, the
PCI
group had a lower hazard of myocardial infarction (hazard ratio [
HR
], 0.177;
P
=0.039; 95% confidence interval [
CI
], 0.03–0.91) and the composite of total death or myocardial infarction (
HR
, 0.298;
P
=0.017; 95%
CI
, 0.11–0.80); however, it showed higher hazard of target lesion revascularization (
HR
, 3.942;
P
=0.003; 95%
CI
, 1.58–9.81) and target vessel revascularization (
HR
, 4.218;
P
=0.001; 95%
CI
, 1.85–9.60). After propensity score matching, a total of 158 matched pairs were generated. Although the
PCI
group showed a higher hazard of target lesion revascularization (
HR
, 2.868;
P
=0.027; 95%
CI
, 1.13–7.31) and target vessel revascularization (
HR
=2.62;
P
=0.022; 95%
CI
, 1.15–5.97), it still exhibited a lower incidence of the composite of total death or myocardial infarction (
HR
, 0.263;
P
=0.017; 95%
CI
, 0.087–0.790). The mean ejection fraction was improved from 47.8% to 51.6% (
P
<0.001) after
PCI
.

Conclusions

In our study, successful revascularization by
PCI
for chronic total occlusion lesions with well‐developed collaterals was associated with lower incidence of death and myocardial infarction, improved left ventricular function, but increased repeat revascularization rate.
Fifty top-cited spine articles from mainland China: A citation analysis
Authors: Wu Yaohong , Zhao Yachao , Lin Linghan , Lu Zhijun , Guo Zhaoyang , Li Xiaoming , Chen Rongchun , Ma Huasong 
Published: September 2017

Objective To identify the 50 top-cited spine articles from mainland China and to analyze their main characteristics. Methods Web of Science was used to identify the 50 top-cited spine articles from mainland China in 27 spine-related journals. The title, year of publication, number of citations, journal, anatomic focus, subspecialty, evidence level, city, institution and author were recorded. Results The top 50 articles had 29–122 citations and were published in 11 English-language journals; most (32) were published in the 2000s. The journal Spine had the largest number of articles and The Lancet had the highest impact factor. The lumber spine was the most discussed anatomic area (18). Degenerative spine disease was the most common subspecialty topic (22). Most articles were clinical studies (29); the others were basic research (21). Level IV was the most common evidence level (17). Conclusions This list indicates the most influential articles from mainland China in the global spine research community. Identification of these articles provides insights into the trends in spine care in mainland China and the historical contributions of researchers from mainland China to the international spine research field.
The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke
Authors: Loos Caroline MJ , McHutchison Caroline , Cvoro Vera , Makin Stephen DJ , Staals Julie , Chappell Francesca , Dennis Martin S , van Oostenbrugge Robert J , Wardlaw Joanna M 
Published: September 2017

Background and aims Individual MRI markers of cerebral small vessel disease are associated with gait impairment. The impact of total cerebral small vessel disease-related brain damage, expressed by a cerebral small vessel disease MRI burden score, on mobility after stroke, has not been considered, although this score gives a better representation of the overall effect of cerebral small vessel disease on the brain. We determined if the total cerebral small vessel disease burden is associated with gait impairment three years after minor stroke. Methods In total, 200 patients with minor lacunar or non-lacunar stroke (NIHSS ≤ 7) underwent a brain MRI at presentation. Presence of lacunes, white matter hyperintensities, cerebral microbleeds, and perivascular spaces were summed in a total cerebral small vessel disease MRI burden score (range 0–4). Gait disturbances, measured by timed-up-and-go test and self-reported stroke impact scale mobility domain were assessed three years after stroke. We tested associations adjusted for key variables by linear regression analysis. Results Total cerebral small vessel disease burden was not associated with gait impairment after minor stroke in all patients, nor in lacunar stroke patients ( n = 87). In non-lacunar stroke patients ( n = 113), total cerebral small vessel disease burden was associated with lower stroke impact scale mobility domain scores, independent of age, vascular risk factors, and stroke severity (unstandardized B −4.61; 95% CI −8.42; −0.79, p < 0.05). Conclusion Patients with non-lacunar stroke and a higher total cerebral small vessel disease burden have more subjective mobility impairment three years after stroke. The total cerebral small vessel disease MRI burden score is a possible marker to identify patients at risk for subjective gait impairment. These findings should be confirmed in larger studies.
Emergency Medicine Pharmacist Impact on Door-to-Needle Time in Patients With Acute Ischemic Stroke
Authors: Jacoby Joshua S. , Draper Heather M. , Dumkow Lisa E. , Farooq Muhammad U. , DeYoung G. Robert , Brandt Kasey L. 
Published: September 2017

Background and Purpose: Decreased door-to-needle (DTN) time with tissue plasminogen activator (tPA) for acute ischemic stroke is associated with improved patient outcomes. Emergency medicine pharmacists (EMPs) can expedite the administration of tPA by assessing patients for contraindications, preparing, and administering tPA. The purpose of this study was to determine the impact of EMPs on DTN times and clinical outcomes in patients with acute ischemic stroke who receive tPA in the emergency department. Methods: A retrospective, single-center, cohort study of patients who received tPA between August 1, 2012, and August 30, 2014, was conducted to compare DTN times with or without EMP involvement in stroke care. Secondary outcomes included changes in neurological status as measured by the National Institutes of Health Stroke Scale (NIHSS), length of hospital stay, discharge disposition, symptomatic intracranial hemorrhage, and in-hospital all-cause mortality. Results: A total of 100 patients were included. The EMPs were involved in the care of 49 patients. The EMP involvement was associated with a significant improvement in DTN time (median 46 [interquartile range IQR: 34.5-67] vs 58 [IQR: 45-79] minutes; P = .019) and with receiving tPA within 45 minutes of arrival (49% vs 25%, odds ratio [OR]: 2.81 [95% confidence interval [CI]: 1.21-6.52]). National Institutes of Health Stroke Scale scores were significantly improved at 24 hours post-tPA in favor of the EMP group (median NIHSS 1 [IQR: 0-4] vs 2 [IQR: 1-9.25]; P = .047). Conclusions: The EMP involvement in initial stroke care was associated with a significant improvement in DTN time.
The effect of off-hours hospital admission on mortality and clinical outcomes for patients with upper gastrointestinal hemorrhage: A systematic review and meta-analysis of 20 cohorts
Authors: Xia Xian Feng , Chiu Philip Wai Yan , Tsoi Kelvin Kam Fai , Chan Francis Ka Leung , Sung Joseph Jao Yiu , Lau James Yun Wong 
Published: September 2017

ObjectiveThe objective of this article is to evaluate the relationship between off-hours hospital admission (weekends, public holidays or nighttime) and mortality for upper gastrointestinal hemorrhage (UGIH).MethodsMedline, Embase, Scopus, and the Chinese Biomedical Literature were searched through December 2016 to identify eligible records for inclusion in this meta-analysis. A random-effects model was applied.ResultsTwenty cohort studies were included for analysis. Patients with UGIH who were admitted during off-hours had a significantly higher mortality and were less likely to receive endoscopy within 24 hours of admission. In comparison to variceal cases, patients with nonvariceal bleeding showed a higher mortality when admitted during off-hours. However, for studies conducted in hospitals that provided endoscopy outside normal hours, off-hours admission was not associated with an increased risk of mortality.ConclusionOur study showed a higher mortality for patients with nonvariceal UGIH who were admitted during off-hours, while this effect might be offset in hospitals with a formal out-of-hours endoscopy on-call rotation.