bluuebunny/crossref_metadata_2025_split huggingface dataset:
Milestones in the History of the Establishment of the Oncological Service of the Russian Federation: Analysis of the Prerequisites, Significance and Results of the Implementation of the Historic Decree of 1945. Review of archival materials on the eve of the 80th anniversary of the Decree of the Council of People's Commissars of the USSR of 30.04.1945 No. 935 «On Measures to Improve the Cancer Care of the Population»
Authors: Аксенова Ирина Алексеевна , Попова Надежда Владимировна , Старинский Валерий Владимирович , Ходакова Ольга Владимировна 
Published: September 2024

В рамках изучения истоков организации доступности квалифицированной медицинской помощи пациентам с онкологическими заболеваниями было изучено постановление Совета Народных Комиссаров СССР от 30.04.1945 № 935 «О мероприятиях по улучшению онкологической помощи населению» (далее — Постановление СНК), которое было нацелено на выстраивание в СССР цельной многоуровневой системы оказания медицинской помощи и вместе с этим на организацию отдельных звеньев онкологической службы. В силу сложившейся к концу Великой Отечественной войны (далее — ВОВ) необходимости организации полноценной системы оказания специализированной медицинской помощи пациентам с онкологическими заболеваниями, с одной стороны, и, с другой стороны, наличия неблагоприятных условий послевоенного периода, разрушенной на большой территории инфраструктуры, дефицита медицинских кадров, реализация поставленных целей сопровождалась большим количеством сложностей. Усилия, вложенные в реализацию Постановления СНК, вовлеченность в работу различных ведомств воистину представляют собой подвиг советского народа. Структурные преобразования онкологической службы, утвержденные Постановлением СНК, сформировали основу системы оказания медицинской помощи пациентам с онкологическими заболеваниями, которая по сей день успешно функционирует и непрерывно совершенствуется.
Development of Palliative Care in St. Petersburg. Dedicated to A.V. Gnezdilov
Authors: Вагайцева Маргарита Валерьевна , Рязанкина Алла Алексеевна , Джалилова Анастасия Андреевна , Волков Николай Олегович , Сенчук Руслана Богдановна , Семиглазова Татьяна Юрьевна , Беляев Алексей Михайлович 
Published: September 2024

Сегодня во всем мире наблюдается рост показателя распространённости злокачественных новообразований, который обусловлен не только увеличением заболеваемости, но и такими факторами, как выявляемость заболевания и повышение длительности жизни пациентов на этапе ремиссии. При этом также выявляется рост показателей инкурабельности онкологических пациентов. Зарубежные исследования указывают на то, что в XXI в. онкологические заболевания оказались основной причиной смертности. Смерть от злокачественных образований в России занимает второе место после болезней системы кровообращения. В случае выявления инкурабельности заболевания пациентам показана паллиативная медицинская помощь. Ежегодно около 40 % госпитализаций в хоспис приходятся на онкологическую патологию. В России оказание паллиативной помощи имеет давние истоки, и её характер трансформировался на протяжении всего прошлого века. Целью данной статьи является исторический очерк и обзор актуального состояния хосписного движения в Санкт-Петербурге.
Reading habits of student teachers studying at a distance-learning institution in South Africa
Authors: Le Roux Sarlina G. 
Published: September 2024

Background: South Africans are widely perceived as not being a reading nation. For many South African children, their first encounter with books and stories occurs when they formally enter the schooling system. This raises the question of how teachers understand their role as reading role models.Objectives: This article aims to investigate how pre-service teachers who are registered at an open distance learning institution evaluate their reading habits.Method: The study employed phenomenography as a research design. All students registered for the Children’s Literature module in 2023 were invited to participate in the study. The submissions of a formal forum discussion assessment of students who agreed to participate in the study were analysed and arranged in themes and codes using Atlas.ti.Results: The article shows that most students perceive themselves as readers, though for varied reasons. The findings suggest the rejection of a monolithic definition of a reader identity. Instead, the notion of categories of readers provides more valuable information for understanding reading behaviour and reader identities.Conclusion: This study confirmed that pre-service teachers are aware of the benefits of reading, though their actions to improve their reading ability, are inadequate.Contribution: Since pre-service teacher training is arguably an important opportunity for addressing the literacy crisis, the findings of this study emphasise the important role of teachers as reading role models.
‘What are they thinking of?’
Authors: Grenfell Michael 
Published: September 2024

This article explains the thinking underlying recent activism in digital markets by competition regulators – with reference to cases undertaken by the CMA, the European Commission and the US authorities, and to the new UK and EU regulatory regimes for competition in digital markets. It addresses some common misconceptions about competition authorities’ thinking on digital markets, and identifies strategies most likely to be effective for tech companies in dealing with competition authorities.
It argues that: (i) the consumer and competition benefits brought by the tech industry are real and substantial; (ii) contrary to common belief, these benefits are recognized by competition authorities; (iii) recent competition regulatory activism should be understood in the context of a belief that it is necessary to preserve those benefits, by allowing new generations of tech disruptors to emerge; (iv) when tech companies face competition investigations or interventions, they should resist the temptation to kneejerk dismissal of all possible concerns, which is unlikely to be effective in advancing their business interests, because it misunderstands the authorities’ thinking; and (v) smarter strategies involve engaging with the specific facts of a particular case (economic, legal and technical) to challenge whether proposed interventions or remedies are, in reality, both effective and proportionate.
DESIGN AND IMPLEMENTATION OF WEB-BASED REGISTRATION SYSTEM IN KLINIK MEDIKA ANTAPANI BANDUNG USING BLACK BOX TESTING
Authors: Purnama Eris Dwi , Putra Fierzha Anugrah 
Published: September 2024

Klinik Medika Antapani is a business entity that serves the community in providing public health services for the community. Currently the patient registration process at Klinik Medika Antapani still uses a stand-alone desktop based application with Microsoft access which still causes queues in the registration section and through conventional registration via Whatsapp. An information system is needed to implement a more effective and efficient service concept at Klinik Medika Antapani. Web-based patient registration applications is one of the best suitable sollution for implemented in Klinik Medika Antapani. Web-based Patient registration application are way more easier to access because they only require a LAN or WAN internet connection and can be accessed directly without having to install the application to the computer. This Web Based Registration System will be very effective if implemented in Klinik Medika Antapani which is still based on onsite registration and manual registration through Whatsapp.
Faktor Penyebab Menurunya Wisatawan Berkunjung Ke Objek Wisata Kadelang Fatang
Authors: Mani imelda blegur  , Melki  imamastri Puling Tang  , Nehemia Fanpada  , Jeni Soekarni Haan  , Padamani Mathias , Markus Guntur Ridho Famai  , Julminggu Selly  
Published: September 2024

This study aims to examine the factors causing the decline in the number of touristsvisiting the Object KADELANG FATANG Beach District of Teluk Mutiara This study aims to examine the factors causing the decline in the number of touristsvisiting the Object Tourism Tirtayasa Beach District of Teluk Betung .Data collection with observation, interview and document ationt echniques. The results showed:The decrease of tourists visiting the beach Tirtayasa caused by the attractiveness ofthe beach kadelang Fatang is less attractive because of the beauty of the environment is lessbeautiful, cleanliness of the dirty environment and diversity of water games are notinteresting. Infrastructure is less good because it is difficult to get clean water and garbagedis system isnot good. The facilities are poorly maintained and incomplete. Unsafe security situation and lack of promotion and information.
This research uses a descriptive method. Data collection with observation, interview anddocument ationt echni ques. Data analysis using scoring with Strutuges model. The results showed:The decrease of tourists visiting the beach kadelang Fatang caused by the attractiveness ofthe beach kadelang Fatang is less attractive because of the beauty of the environment is lessbeautiful, cleanliness of the dirty environment and diversity of water games are notinteresting. Infrastructure is less good because it is difficult to get clean water and garbagedi sposal system is not good. The facilities are poorly maintain edandin complete. Unsafe security situation and lack of promotion and information.
Peningkatan Rasa Persatuan Dan Kesatuan Dalam Membangun Filsafat Pancasila Di SDN Gili Barat
Authors: Hikmah Labibah  , Dya A'yun  
Published: September 2024

The study discussed the implementation of the 3rd pancasila of the west bank to increase unity and unity among students. The implementation of pancasila values is done through activities that teach cultural diversity, build teamwork, and foster tolerance and appreciation for differences among students. The essential role of teachers and parents in instilling the values of unity and unity in students is also taught in this study. The research method used is qualitative descriptive using data collection techniques by observation and interview. Observations indicate that the application of the pancasila values is done through division of students into groups to find solutions to the given problem. Additionally, the study also highlights the problem of integrating the values of unity and unity among students, particularly in class v, and suggests that teachers focus more on organizing classes and maximizing learning to increase the sense of unity and unity among students.
Mining Potential Molecular Markers and Therapeutic Targets of COPD Based on Transcriptome-Sequencing and Gene-Expression Chip
Authors: Zhang Lihai , Jia Xiaodong , Zhang Zhipeng , Yu Tong , Geng Zhangyan , Yuan Lindong 
Published: September 2024

IntroductionChronic obstructive pulmonary disease (COPD) is a progressive lung disorder marked by persistent respiratory symptoms and escalating airflow obstruction. The global rise in COPD incidence and mortality poses a significant societal burden. Despite its prevalence, the intricate pathogenesis of COPD remains incompletely understood. This study aims to elucidate molecular markers and potential therapeutic targets by integrating known COPD-related genes and analyzing RNA-Seq and expression microarray data.Material and methodsWe conducted a comprehensive analysis by combining RNA-Seq and expression microarray data for COPD, focusing on known COPD-associated genes. Differential expression analysis revealed insights into the cellular biological processes and signaling pathways underlying COPD pathogenesis. Functional modules closely linked to COPD were identified through protein interaction network analysis.ResultsThe analysis of differentially expressed genes (DEGs) highlighted the significance of cellular processes such as chemotaxis, cell migration, cellular stress, and apoptosis in COPD pathogenesis. Key signaling pathways, including NF-kappa B, JAK-STAT, T cell receptor, and NOD-like receptor pathways, were identified as crucial contributors to COPD development. Protein interaction network analysis unveiled functional modules associated with COPD. Validation through qRT-PCR and immunoblotting confirmed PTX3 and CYP1B1 as core genes, suggesting their potential as biomarkers and therapeutic targets for COPD.ConclusionsOur findings provide valuable insights into the molecular landscape of COPD, identifying PTX3 and CYP1B1 as promising candidates for further investigation as potential biomarkers and therapeutic targets. This research contributes to a better understanding of COPD pathogenesis, offering avenues for the development of targeted interventions to address this escalating global health concern.
A simplified cardiac amyloidosis score is associated with all-cause and cardiovascular disease mortality and morbidity, in the general population: the Ikaria Study.
Authors: Chrysohoou Christina , Panagiotakos Demosthenes , Tsiachris Dimitrios , Dimitriadis Kyriakos , Lazaros George , Tsioufis Kostas , Stefanadis Christodoulos 
Published: September 2024

IntroductionTransthyretin amyloid cardiomyopathy (ATTR-CM) is an under-appreciated disease. The aim of this study was to evaluate the T-Amylo score, i.e., ATTR-CM related, in relation to all-cause and cardiovascular disease (CVD) morbidity and mortality, in the general population.Material and methodsThe T-Amylo score (range 0-11) is based on clinical and echocardiographic features (age and gender, IVSd thickness >=16 mm, low QRS interval voltage, and carpal tunnel syndrome) that have been previously introduced in clinical practice.ResultsDuring 2009, 1,420 middle aged and older inhabitants agreed to enroll into the Ikaria study (678 males aged 67(14) years, and 742 females aged 66(14) years); in 2013, the participants were re-evaluated. Survival analysis revealed that the T-Amylo prediction score was associated with all-cause mortality (Hazard Ratio 1.59, 95%CI 1.40 to 1.81), and the risk of combined CVD events (1.32, 95%CI 1.11 to 1.56), after various adjustments made. ROC analysis revealed that the AUC of T-Amylo score was 0.70, the accuracy was 81.52%, and the net-reclassification indices suggested better reclassification performance than its components. Stratifying by age group, the score predicts all-cause and CVD mortality and morbidity only among >65 years old individuals.ConclusionsThe prognostic value for CVDs of the T-Amylo score observed here seems promising for its use in the general population, too.
sαKlotho protein is a useuful biomarker and a promising cardioprotective agent in acute heart failure
Authors: Płonka Joanna , Olejnik Agnieszka , Klus Anna , Gawrylak-Dryja Ewa , Wężyk Natalia , Rzepiela Lidia , Dąbrowska Klaudia , Bil-Lula Iwona , Gierlotka Marek 
Published: September 2024

IntroductionAcute heart failure (AHF) is a heterogeneous and etiologically complex syndrome with bad prognosis. sαKlotho (sαKL) is an antiaging protein with pleiotropic actions. The aim of the study was to assess the level and kinetics of sαKl during an episode of AHF and its long-term prognostic utility in population of AHF patients.Material and methodsIt was a prospective multicenter study, which enrolled 133 participants. 112 consecutive patients were admitted to the intensive cardiac care unit with diagnosis of AHF (age 68[IQR,60-75] years, ejection fraction 30%[IQR,20-38], new-onset AHF 46% of the population). 21 individuals consisted the control group. sαKl, N-terminal pro-B-type natriuretic peptide (NT-proBNP) were determined in serum at admission and at discharge. The main clinical outcomes assessed in the study were 3 year all-cause mortality or HF rehospitalization.ResultssαKl concentration significantly increased during episode of AHF. A weak negative correlation was observed between sαKl and NT-proBNP at admission and discharge. Only patients with ischemic etiology of AHF did not have considerably elevated sαKl values at admission. Both, women and men had similar values of biomarker. Smoking did not affect sαKl in our study. Patients who developed the combined endpoint during 3 year follow-up presented poor increase in sαKl values on admission compared to control group (p=0.169) and weak biomarker kinetics during hospitalization as compared with group free of outcomes (p=0.01).ConclusionssαKl level is upregulated during an acute episode of HF and may acts as a useful biomarker. Weak reduction in sαKl levels during treatment indicate patients with poor long-term prognosis.
PERANCANGAN IMPLEMENTASI ENERGI TERBARUKAN DAN PENGATURAN IOT PADA KELISTIKAN DESA TERPENCIL
Authors: Agus Wibowo  
Published: September 2024

Listrik merupakan kebutuhan pokok manusia saat ini. namun tidak ada listrik on-grid yang tersambung ke desa terpencil. Warga desa mencoba mengatasi sendiri berdasarkan pengetahuan dan kemampuan yang terbatas. Peneliti terpanggil untuk memberikan solusi, bagaimana warga desa mendapatkan listrik off-grid secara berkelanjutan. Peneliti harus datang untuk meneliti ketersediaan sumber energi lokal terbarukan, seperti tenaga surya, mikrohidro, dan tenaga angin yang dapat diubah menjadi tenaga listrik. Solusi ini akan menjadi solusi yang lebih baik bagi desa terpencil. Juga dapat menjadi contoh bagi desa-desa lainnya. Energi terbarukan yang berbasis pada sumber daya alam sekitar merupakan sebuah pemikiran yang baik. Layanan berkelanjutan dapat diperoleh dengan menggabungkan sumber daya. Pengontrol IoT diimplementasikan untuk mengatur berbagai energi listrik, yang akan menghasilkan tenaga listrik yang berkualitas dan stabil, namun tetap irit dan efisien. Penggunaan energi terbarukan secara off-grid adalah solusi tercepat. biayanya lebih rendah dibandingkan dengan genset diesel karena pengoperasiannya lebih lama. Hal itu juga sebagai enegi ramah lingkungan yang terbebas dari polusi)
The Effect of Family Planning Counseling for Pregnant Women in the Third Trimester of Participation in Post-Department Family Planning in the Work Area of UPT Puskesmas Kalampangan, Palangka Raya City
Authors: Niyatie Neiba , Herlinadiyaningsih  , Oktaviani  
Published: September 2024

Latar Belakang: Keluarga Berencana adalah usaha mengatur jumlah dan jarak anak yang diinginkan. Berdasarkan proporsi waktu pelayanan KB pasca persalinan di Indonesia 67,5 % ibu nifas baru menggunakan alat kontrasepsi diatas 42 hari setelah persalinan, 20% setelah pulang dari fasilitas kesehatan sampai dengan 42 hari setelah persalinan, 7,3% bersamaan dengan proses persalinan dan sebanyak 5,2% setelah persalinan selesai tetapi belum pulang dari fasilitas kesehatan
Metodologi Penelitian: Penelitian ini menggunakan rancangan pre eksperimen. Sampel penelitian ibu hamil trimester III (usia kehamilan 28-42 minggu) di Wilayah Kerja Puskesmas Kalampangan dan memenuhi kriteria inklusi, sebanyak 33 orang
Hasil : Jumlah responden 33 orang, Karakteristik responden mayoritas tingkat pengetahuan kurang (57,5%), sikap baik (54,5%), umur 20-35 tahun (78,8%), berpendidikan menengah (42,4%) dan tinggi (42,4%), tidak bekerja (72,7%), paritas multigravida (66,7%) dan melahirkan di fasilitas Kesehatan (78,8%). Rerata tingkat pengetahuan sebelum konseling adalah 56,3 dan sesudah konseling adalah 79,7. Hasil analisis disimpulkan ada pengaruh konseling KB terhadap tingkat pengetahuan ibu (p-value 0,000), tidak ada pengaruh konseling KB dengan sikap ibu (p-value 0,354) dan ada pengaruh konseling KB dengan keikutsertaan KB pasca persalinan (p-value 0.004). Perlu adanya kesiapan petugas Kesehatan khususnya bidan dalam pemberian konseling KB pada ibu hamil dan adanya peningkatan kemampuan/ kompetensi petugas dalam melakukan konseling
<span><strong>Một số biện ph&aacute;p ph&aacute;t triển năng lực tư duy v&agrave; lập luận to&aacute;n học cho học sinh th&ocirc;ng qua dạy học giải b&agrave;i tập chủ đề đại số tổ hợp &ndash; To&aacute;n 10</strong></span>
Authors: Nguyễn Văn Khang , Lê Hoàng Mai 
Published: September 2024

Phát triển năng lực toán học nói chung, năng lực tư duy và lập luận trong dạy học môn Toán trung học phổ thông nói riêng đóng vai trò quan trọng trong việc đáp ứng mục tiêu của chương trình giáo dục phổ thông môn Toán năm 2018. Trong chương trình giáo dục phổ thông môn Toán năm 2018, nội dung chủ đề Đại số tổ hợp - Toán 10 có những khái niệm có thể vận dụng để giải các bài toán thực tiễn. Ngoài việc cung cấp những khái niệm và công cụ cần thiết để giải quyết những bài toán đếm thường gặp trong thực tế cuộc sống, một trong những ứng dụng trực tiếp là phục vụ cho việc học tập nội dung xác suất trong chương trình Toán. Nhìn chung, nội dung của chủ đề này là tương đối khó và khá trừu tượng đối với học sinh lớp 10. Thông qua các dạng bài tập chủ đề Đại số Tổ hợp học sinh có nhiều cơ hội phát triển năng lực toán học nói chung, năng lực tư duy và lập luận toán học cho học sinh nói riêng. Trong bài viết này, chúng tôi đưa ra các định hướng và đề xuất một số biện pháp nhằm phát triển năng lực tư duy và lập luận toán học cho học sinh lớp 10 thông qua dạy học giải bài tập chủ đề Đại số tổ hợp – Toán 10, nhằm góp phần nâng cao chất lượng dạy học môn toán ở trường trung học phổ thông, đáp ứng mục tiêu chương trình giáo dục phổ thông 2018.
place of uterine artery and umbilical artery doppler in prediction of hypertensive disorders (pre-eclampsia) among pregnant women at a resource poor setting
Authors: Nwali Matthew Igwe , Chikezie Raphael Ugochukwu , Ikeotuonye Arinze , Ugo-chikezie Nwamaka , Anidiobi Fidelis Nwamkwo , Dimejesi Ikechukwu B O , Uchendu Emmanuel , Onuchukwu Victor 
Published: September 2024

Background: Uterine and umbilical artery Doppler velocimetry have shown promise but the results of previous studies have not been conclusive/poor methodologies. Aim: To determine the predictive value of uterine and umbilical artery Doppler velocimetry for pre-eclampsia and pregnancy outcomes. Methods: A comparative study among 100 women who attended ante natal clinic in the hospital within the study period who has high risk for development of pre-eclampsia. The peak systolic velocity, end-diastolic velocity, Resistivity index, Pulsatility index and S/D ratio of the uterine and umbilical arteries were studied at 18-20 weeks and 36-37 weeks. sociodemographic data were recorded. Data were analysed using SPSS (version 26, Chicago11, USA). P value of ≤ 0.05 was significant. Results: Resistivity/Pulsatility indices at 18-20 weeks are better predictors of preeclampsia as against EDV at 36-37 weeks. Pregnant women at 18-20 weeks gestational showed that only mean RI (≈ 0.53 0.02) of the umbilical artery was associated with adverse outcome (p = 0.009). However, at 36-37 weeks, the mean uterine artery EDV of 14.69 2.04 was associated with adverse outcome (p = 0.001). Conclusion Adverse pregnancy outcome at n18-20 weeks was associated with resistivity index while EDV is more associated with adverse outcomes at 36-37 weeks.
ANALIS MAKNA CERPEN DENGAN PENDEKATAN OBJEKTIF
Authors: Suzetta Feby  , Tazkya Kuntadi Nayla  
Published: September 2024

Dalam cerpen terdapat unsur-unsur yang membangun cerpen yaitu tema, penokohan, alur dan bahasa yang digunakan. Unsur tersebut memiliki hubungan fungsional dalam membangun cerita sehingga menghasilkan pemaknaan yang utuh terhadap karya. Pendekatan Objektif ialah Pendekatan yang memandang dan menelaah sastra dari segi intrinsik yang membangun sebuah karya sastra. yaitu tema, alur, latar, Penokohan dan gaya Bahasa. Langkah- Langkah dalam penerapan objektif antara lain yaitu Langkah pertama seorang yang menganalisis harus mengetahui tema apa yang akan di analisinya. Langkah kedua melakukan analisis terhadap usur- unsur yang terdaat dalam unsur intrinsik, seperti tema, alur, latar, Penokohan dan gaya Bahasa. langkah ketiga mengaitkan hasil analisisnya berdasarkan unsur – unsur yang di analisis.