bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategic innovation ambidexterity and the internationalization performance of small and medium enterprises: an insight into herbal-based small and medium enterprises (HbSMES)
Authors: Mashahadi Faizah , Ahmad Noor Hazlina , Mohamad Osman 
Published: April 2016

Purpose
This paper aims to explain the relationship between strategic technological and non-technological innovation ambidexterity and the internationalization performance of HbSMEs.

Design/methodology/approach
The theory of dynamic capability is highlighted as the main approach to enhance the internationalization performance of HbSMEs. It spells on the importance of continuous improvement, which can be realized by renewing and reconfiguring businesses competencies in response to the changing nature of business environment. The respondents composed of 310 HbSMEs that involve actively in international business activity. The data is analyzed using partial least squares.

Findings
The results indicate that only strategic non-technological innovation ambidexterity plays critical role in determining the internationalization performance of HbSMEs, while strategic technological innovation ambidexterity creates non-significant impact.

Originality/value
As resource-constrained enterprises, innovation activity imposed undue burden to Small and Medium Enterprises (SMEs). However, since people are started to shift their preferences on herbal-based products, strategic innovation ambidexterity is critical for HbSMEs to respond to the global herbal market. This research may provide information in which area of innovation should be emphasized by HbSMEs. Here, strategic non-technological innovation ambidexterity has been observed to create positive and significant impact on the internationalization performance of HbSMEs. Therefore, exploiting the existing marketing capability and concurrently exploring new marketing capability are critical for HbSMEs so that businesses could improve its performance in the turbulent nature of international business environment.
Clinical and dermoscopic changes of vulvar lichen sclerosus after topical corticosteroid treatment
Authors: Borghi Alessandro , Corazza Monica , Minghetti Sara , Toni Giulia , Virgili Annarosa 
Published: April 2016

AbstractWith the aim to assess changes in both clinical and dermoscopic features of vulvar lichen sclerosus (VLS) after a treatment with topical corticosteroid, 29 VLS patients treated with mometasone furoate 0.1% ointment for 12 weeks were evaluated for symptoms, objective signs and dermoscopic variables at baseline and treatment completion. Numeric scores were assigned to each parameter. Mean itching and burning values had decreased significantly at the 12‐week control visit compared with baseline, as well as values referring to pallor, hyperkeratosis and purpuric lesions. Among the dermoscopic variables, the vessel score increased while the scores of patchy, structureless, whitish areas, whitish background, purpuric globules and scales decreased significantly after treatment. Scores referring to gray‐blue dots, comedo‐like openings and structures like ice slivers did not change significantly throughout the treatment. Based on these findings, dermoscopic features may change, even significantly, with topical corticosteroids and may be useful for monitoring the response to treatment.
Histopathological diagnosis of epithelial crateriform tumors: Keratoacanthoma and other epithelial crateriform tumors
Authors: Ogita Azusa , Ansai Shin‐ichi , Misago Noriyuki , Anan Takashi , Fukumoto Takaya , Saeki Hidehisa 
Published: April 2016

AbstractKeratoacanthoma (KA) is a unique and distinct clinicopathological entity, although there is often confusion regarding its differentiation from other types of crateriform tumors. In this study, the clinicopathological features of 380 epidermal crateriform tumors with a central keratin plug were re‐examined and the tumors were histologically classified into seven types: (i) crateriform verruca; (ii) crateriform seborrheic keratosis; (iii) KA; (iv) KA with a conventional squamous cell carcinoma (SCC) component (KA‐like SCC and KA with malignant transformation); (v) crateriform Bowen's disease; (vi) crateriform SCC arising from solar keratosis; and (vii) crater form of infundibular SCC. Our study proved that incidence of SCC developing in KA lesions was 17.4%. The incidence rate differed depending on a patient's ages: 8.3% in patients less than 70 years of age and 24.3% in those aged 70 years and older. Nearly all of the malignant crateriform neoplasms (94.7%) occurred on sun‐exposed areas. Lesions on the face included 138 KA (59.5%), 65 malignant crateriform neoplasms (28%) and 29 benign crateriform neoplasms (12.5%). We conclude that KA is not a variant of SCC, but a benign and frequently regressing proliferative lesion or borderline neoplasm, although there is the potential for SCC to arise within KA. Because the incidence of SCC developed in KA lesions and the incidence of other malignant crateriform neoplasms are higher in patients aged 70 years and older, KA‐like lesions on sun‐exposed areas over 70 should be assessed carefully in consideration of the potential risk of malignancy.
CD34‐positive infantile myofibromatosis: Case report and review of hemangiopericytoma‐like pattern tumors
Authors: Kiyohara Takahiro , Maruta Naoki , Iino Shiro , Ido Hideki , Tokuriki Atsushi , Hasegawa Minoru 
Published: April 2016

AbstractWe describe a case of CD34‐positive infantile myofibromatosis with hemangiopericytoma‐like pattern. A 2‐day‐old Japanese boy presented with multiple hemispherical nodules on the extremities and back. There was a biphasic histological growth in the dermis, accompanied by a hemangiopericytoma‐like pattern with antler‐like branching vessels. Tumor cells were oval to spindle‐shaped myoid cells with bland appearance. Immunohistochemically, vimentin, calponin and CD34 were positive, while α‐smooth muscle actin, h‐caldesmon, HHF35 and desmin were negative. Although CD34 was positive, the present case could be diagnosed as infantile myofibromatosis. Myopericytoma, myofibroma/myofibromatosis, glomus tumor, glomangiopericytoma and angioleiomyoma share a continuous spectrum of benign hemangiopericytoma‐like pattern tumors. Myofibroma/myofibromatosis is nearly included in myopericytoma among pericytic (perivascular) tumors, and could be positive for CD34. Several immunohistochemical panels of smooth muscle markers are needed for the diagnosis of pericytic (perivascular) tumors.
The Monosyllable Imitation Test for Toddlers: influence of stimulus characteristics on imitation, compliance and diagnostic accuracy
Authors: Hodges Rosemary , Munro Natalie , Baker Elise , McGregor Karla , Heard Rob 
Published: April 2016

AbstractBackgroundAlthough verbal imitation can provide a valuable window into the developing language abilities of toddlers, some toddlers find verbal imitation challenging and will not comply with tests that involve elicited verbal imitation. The characteristics of stimuli that are offered to toddlers for imitation may influence how easy or hard it is for them to imitate. This study presents a new test of elicited imitation—the Monosyllable Imitation Test for Toddlers (MITT)—comprising stimuli of varying characteristics and test features designed to optimize compliance.AimsTo investigate whether the stimulus characteristics of neighbourhood density and consonant complexity have independent and/or convergent influences on imitation accuracy; and to examine non‐compliance rates and diagnostic accuracy of the MITT and an existing test, the Test of Early Nonword Repetition (TENR) (Stokes and Klee 2009a).Methods & ProceduresFifty‐two toddlers (25–35 months) participated. Twenty‐six had typically developing language (TDs) and 26 were defined as late talkers (LTs) based on parent‐reported vocabulary. The MITT stimuli were created by manipulating both neighbourhood density (dense or sparse) and consonant complexity (early‐ or late‐developing initial consonant). The MITT was designed to maximize compliance by: (1) using eight monosyllabic stimuli, (2) providing three exposures to stimuli and (3) embedding imitation in a motivating context: a computer animation with reasons for imitation.Outcomes & ResultsStimulus characteristics influenced imitation accuracy in TDs and LTs. For TDs, neighbourhood density had an independent influence, whereas for LTs consonant complexity had an independent influence. These characteristics also had convergent influences. For TDs, stimuli were all equally easy to imitate, except those that were both sparse and contained a late‐developing consonant which were harder to imitate. For LTs, stimuli that were both dense and contained an early‐developing consonant were easier to imitate than any other stimuli. Two LTs and no TDs were non‐compliant with the MITT. With the TENR, five LTs and two TDs were non‐compliant. The MITT and TENR yielded similar levels of diagnostic sensitivity, but the TENR offered higher specificity rates. Subsets of stimuli from the MITT and the TENR also showed diagnostic promise when explored post‐hoc.Conclusions & ImplicationsStimulus characteristics converge to influence imitation accuracy in both TD and LT toddlers and therefore should be considered when designing stimuli. The MITT resulted in better compliance than the TENR, but the TENR offered higher specificity. Insights about late talking, elicited imitation and speech production capabilities are discussed.
Claiming futures
Authors: Ferry Elizabeth 
Published: April 2016

The papers in this special issue on ‘environmental futures’ draw liberally on cross‐disciplinary conversations, yet their strength comes from their ethnographic depth and their characteristically anthropological willingness to consider diverse types of entities and phenomena in the same holistic frame. The range of places (Oman, Alaska, Egypt, Colombia, Antarctica, etc.) and entities (ice, oil, gold, governmental officials, glaciologists, salmon, models and scenarios, PowerPoint presentations, rainfall, etc.) engaged in these instances of ‘prognostic politics’ provide the kind of material that distinguishes the anthropological project of building theory through ethnography and comparison. In writing this response, I group the papers in pairs under four topics that bring out some of the especially interesting and novel contributions of the issue as a whole. The themes are: temporality and uncertainty; anticipatory knowledges; resource affect; and material signs. These themes refract the visions presented in the papers, showing details of the process of claiming multiple uncertain, agonistically engaged futures, and the consequences of these claimed futures. I briefly conclude by considering these papers as part of the current pragmatist (sometimes called ‘ontological’) bent of some anthropological work, and the heuristic possibilities provided by this orientation.
Latent Fingermark Aging Patterns (Part II): Color Contrast Between Ridges and Furrows as One Indicator of Degradation
Authors: De Alcaraz‐Fossoul Josep , Barrot Feixat Carme , Tasker Jack , McGarr Luke , Stow Karen , Carreras‐Marin Clara , Turbany Oset Jaume , Gené Badia Manel 
Published: April 2016

AbstractCurrently, no established methodology exists to determine degradation patterns of latent fingermarks by visual means. This article is the second in a series of reports exploring quantifiable degradation‐related parameters, which focuses on color contrast changes between fingermark ridges and furrows over time. Experiment variables included type of secretion (eccrine and sebaceous), substrate (glass and plastic), and exposure to natural light (dark, shade, and direct light). Fingermarks were sequentially visualized with titanium dioxide powder and photographed. Image histogram profiles were evaluated and combined with statistical analysis of color data values. Results indicate that sebaceous depositions on glass were generally less degraded by the effect of environmental conditions compared with those on plastic. In addition, aging in darkness was not always the best condition for preservation, and direct exposure to light seemed to inhibit visual degradation under certain conditions. Overall, the technique provided sufficient sensitivity to discern degradation patterns of fingermarks.
Human factors in the emergency department: Is physician perception of time to intubation and desaturation rate accurate?
Authors: Cemalovic Nail , Scoccimarro Anthony , Arslan Albert , Fraser Robert , Kanter Marc , Caputo Nicholas 
Published: April 2016

AbstractObjectiveThe main objective of the present study was to examine the perceived versus actual time to intubation (TTI) as an indication to help determine the situational awareness of Emergency Physicians during rapid sequence intubation and, additionally, to determine the physician's perception of desaturation events.MethodsA timed, observation prospective cohort study was conducted. A post‐intubation survey was administered to the intubating physician. Each step of the procedure was timed by an observer in order to determine actual TTI. The number of desaturation events was also recorded.ResultsOne hundred individual intubations were included. The provider perceived TTI was significantly different and underestimated when compared with the actual TTI (23 s, 95% confidence interval (CI) 20.4–25.49 vs 45.5 s, 95% CI 40.2–50.7, P < 0.001, respectively). Pearson correlation coefficient of perceived TTI to actual TTI was r2 = 0.39 (95% CI 0.21–0.54, P < 0.001). The provider perceived desaturation rate was also significantly different from actual desaturation rate (13, 95% CI 3–12 vs 23, 95% CI 13–29, P = 0.05, respectively). The overall time to desaturation was 65.1 s.ConclusionsOur findings have shown that provider's perception of TTI occurs sooner than actually observed. Also, the providers were less aware of desaturation during the procedure.
Estimation of the potential eye and tissue donor pool in an Australian emergency department
Authors: Johnson Damian , Dutch Martin , Knott Jonathan 
Published: April 2016

AbstractObjectiveEDs have long been considered a potential source of eye and tissue donors, but no specific evidence to support this was identified in the Australian setting. The present study aims to bridge that knowledge gap, by analysing medical and social histories of those who have died over a 5 year period so as to determine donation eligibility in this population.MethodsA retrospective audit was undertaken of all patients who died within the Royal Melbourne Hospital ED between 2010 and 2014. ED records, pharmacy records and electronic medical histories were audited for the presence of eye and tissue donation exclusion criteria and the distribution of these criteria within the target population.ResultsOver the 5 year period, of 326 deaths that occurred in the ED, one third was suitable for eye donation (n = 106) and one in seven (n = 45) for tissue donation. Of the age appropriate patients, five criteria were identified that excluded up to 85% of the population not eligible to donate. These were: haematological malignancies, neurodegenerative conditions, non‐haematological malignancies, chronic renal failure and eye disease.ConclusionThe present study has identified a large pool of potential eye and tissue donors; a pool mostly unrecognised by emergency clinicians.An extensive list of exclusion criteria restricts donor potential. However, the present study has identified that only five fundamentally limit donation in the ED population. Utilisation of this knowledge will allow for the development of clinical triggers that will improve identification, and increase realisation, of potential donors.
Pacific ethnic groups and frequent hospital presentation: A fair target?
Authors: Irvine Zoe 
Published: April 2016

AbstractIn New Zealand, Pacific health figures are traditionally presented for all Pacific ethnic groups combined. Use of EDs and urgent care clinics is high compared with Maori and non‐Maori, non‐Pacific (nMnP) use. By controlling for proximity to the hospital and socioeconomic status, we demonstrate greater variation between Pacific ethnic groups than between Pacific and nMnP, or between Maori and nMnP groups. We discuss the significance of subpopulation variation in use of urgent care services.
Development of a Drinkable, Peanut‐Based Dietary Supplement and Comparison of Its Nutritional and Microbiological Qualities with Commercial Products
Authors: Klu Yaa Asantewaa Kafui , Phillips Robert D. , Chen Jinru 
Published: April 2016

AbstractThis study was undertaken to formulate, using peanuts as a major ingredient, a beverage which will benefit older adults who are at a high risk of protein‐energy malnutrition and other health complications, and to compare its nutritional and microbiological qualities to commercial products. Peanuts, rice flour, and flaxseed meal in a ratio of 48.0:49.8:2.2 were mixed with water (20% solids) and cooked into gruel which was sequentially treated with BAN®, (480 KNU‐B/g, 75 °C 1 h), Alcalase® (2.4 AU‐A/g, 60 °C 1 h), and Flavourzyme® (1000 LAPU/g, 55 °C 1 h) to predigest starch and protein, respectively. The degree of hydrolysis and product viscosity during hydrolysis was measured. The nutritional and microbiological qualities of the product were compared to 10 commercial products. Results indicate that 60% of starch was hydrolyzed while a total of 1.62% protein hydrolysis was observed. Product viscosity reduced from 228.55 to 3.60 cP at the end of hydrolysis. The formulation had no cholesterol and low sodium which was a functional property that was absent in the commercial products. Results of this study suggest that the formulation can be further optimized into a unique product that could cater for the protein needs and other nutritional requirements of older adults.
Surgery for the palliation of intestinal perforation from secondary metastases in advanced malignancies
Authors: Ng Deanna Wan Jie , Teo Melissa Ching Ching , Yee Alethea Chung Pheng , Ng Kheng Hong , Wong Ting Hway 
Published: April 2016

AbstractAimThis study aims to review patient and disease factors that predict survival after palliative surgery for intestinal perforation from metastases in advanced malignancies, with a goal to help decision‐making in this clinical scenario. Secondary aims include validation of the UC Davis Cancer Centre nomogram to predict risk of 30‐day morbidity and mortality for patients with disseminated malignancy undergoing surgical intervention.MethodsThe following factors were examined: age, preoperative albumin, total white blood cell count, creatinine, site of metastases, presence of ascites, presence of sepsis, steroid use, presence of dyspnea, presence of significant weight loss, preoperative chemotherapy, preoperative radiotherapy, type of operative procedure performed, Eastern Cooperative Oncology Group (ECOG) status, length of surgery, duration of inhospitalization and mortality. For univariate analysis, independent t‐test and Fisher's exact test were used to analyze the association of continuous and categorical variables, respectively. For multivariate analysis, logistic regression using likelihood ratios was used. The nomogram was validated by assessing its extent of discrimination (c‐index).ResultsTwenty palliative operations for intestinal perforation were performed during this period. On univariate analysis, presence of dyspnea, decreased preoperative levels of albumin and high ECOG status were significant predictors of increased mortality. On multivariate analysis, high ECOG status and decreased preoperative albumin were statistically significant. The concordance index in our data set was 0.64.ConclusionPreoperative levels of albumin (>20 g/L) and low ECOG status (≤1) were independently associated with favorable postoperative outcomes. In patients with favorable prognostic factors such as absence of dyspnea, high preoperative levels of albumin and low ECOG status, surgical management should be considered. Conversely, in patients with unfavorable prognostic factors, medical management should be considered to avoid unnecessary surgery.
Genetic fusion of human FGF21 to a synthetic polypeptide improves pharmacokinetics and pharmacodynamics in a mouse model of obesity
Authors: Yin Jun , Bao Lichen , Tian Hong , Wang Qun , Gao Xiangdong , Yao Wenbing 
Published: April 2016

Background and PurposeChemical conjugation of therapeutic proteins with polyethylene glycol (PEG) is an established strategy to extend their biological half‐life (t1/2) to a clinically useful range. We developed a novel uncharged and unstructured recombinant polypeptide composed of five amino acids (P, S, T, A and G), named PsTag, as another approach to extend the t1/2 of human FGF21, with increased hydrodynamic radius.Experimental ApproachHuman FGF21 was fused with PsTag polymers of differing lengths (200 ‐ 600 residues). Three fusion proteins and native FGF21 were produced in Escherichia coli. The biophysical characteristics, metabolic stability, immunogenicity and pharmacokinetics in were assessed in first. In lean and diet‐induced obese (DIO) mice, effects on body weight, oral glucose tolerance tests and levels of relevant hormones and metabolites were studied.Key ResultsFusion proteins were solubly expressed in E. coli and prolonged the t1/2 from 0.34h up to 12.9 h in mice. Fusion proteins were also biodegradable, thus avoiding vacuole formation, while lacking immunogenicity in mice. In DIO mice, administration of PsTag fused to FGF21 reduced body weight, blood glucose and lipids levels and reversed hepatic steatosis.Conclusions and ImplicationsThe novel recombinant polypeptide, PsTag, should be useful in the development of biological drugs with properties comparable to those achievable by PEGylation, but with potentially less side effects. In mice, fusion of FGF21 to PsTag prolonged and potentiated pharmacological effects of native FGF21, and may offer greater therapeutic effects in treatment of obesity.
A Descriptive Framework for Temporal Data Visualizations Based on Generalized Space‐Time Cubes
Authors: Bach B. , Dragicevic P. , Archambault D. , Hurter C. , Carpendale S. 
Published: April 2016

AbstractWe present the generalized space‐time cube, a descriptive model for visualizations of temporal data. Visualizations are described as operations on the cube, which transform the cube's 3D shape into readable 2D visualizations. Operations include extracting subparts of the cube, flattening it across space or time or transforming the cubes geometry and content. We introduce a taxonomy of elementary space‐time cube operations and explain how these operations can be combined and parameterized. The generalized space‐time cube has two properties: (1) it is purely conceptual without the need to be implemented, and (2) it applies to all datasets that can be represented in two dimensions plus time (e.g. geo‐spatial, videos, networks, multivariate data). The proper choice of space‐time cube operations depends on many factors, for example, density or sparsity of a cube. Hence, we propose a characterization of structures within space‐time cubes, which allows us to discuss strengths and limitations of operations. We finally review interactive systems that support multiple operations, allowing a user to customize his view on the data. With this framework, we hope to facilitate the description, criticism and comparison of temporal data visualizations, as well as encourage the exploration of new techniques and systems. This paper is an extension of Bach et al.'s (2014) work.