bluuebunny/crossref_metadata_2025_split huggingface dataset:
Penggunaan Buku Aktivitas Anak berbasis Augmented Reality (AR) pada Buku Digital Cerdas Indonesia 2
Authors: Fajriati Ruliana 
Published: September 2024

Tidak dapat dipungkiri bahwa perkembangan teknologi saat ini begitu pesat. Teknologi telah mermbah berbagai bidang, termasuk bidang pendidikan. Guru dan orang tua harus melek terhadap perkembangan teknologi agar dapat mendampingi anak-anak belajar. Salah satu teknologi yang dikembangkan dalam bidang pendidikan yaitu buku berbasis Augmented Reality (AR). Saat ini KB Nasyithatun Nisa mencoba memanfaatkan buku aktivitas Digital Cerdas Indonesia 2 berbasis AR. Namun karena keterbatasan informasi, guru merasa kesulitan dalam penggunaanya. Untuk itu penulis melakukan pelatihan dan pendampingan agar dapat memanfaatkan teknologi AR pada buku aktivitas Digital Cerdas Indonesia di sekolah dan orang tua dapat mendampingi anak mengulang pelajaran di rumah. Pelatihan ini diikuti oleh kepala KB Nasyithatun Nisa, 5 guru dan 15 orang tua/wali. Teknologi AR yang menggabungkan dunia maya dengan dunia nyata secara langsung diharapkan dapat meningkatkan imajinasi anak dan meningkatkan minat dalam belajar.
Mapeo narrativo
Authors: Mamber Stephen , Aguilar Alcalá Sergio J. 
Published: September 2024

En el presente artículo, Stephen Mamber expone propósitos, categorías y ejemplos del mapeo narrativo, herramienta que ayuda a comprender narrativas complejas en tiempo y espacio, sean películas, hechos periodísticos, novelas u horarios de una estación de trenes. Los mapas narrativos pueden ser tan complejos y centrados en un tema, como un mapa territorial, que se convierten en la interfaz con la que uno realmente accede al texto. Ya que la narrativa se encuentra en todos lados, Mamber se pregunta si habrá realmente un límite a las posibilidades de mapear nuestro entorno.
legislación del Segundo Imperio. México: Instituto Nacional de Estudios Históricos de las Revoluciones de México
Authors: Torres Alonso Eduardo 
Published: September 2024

La construcción del Estado mexicano resultó ser un proceso intricado, convulso y sangriento. Desde el encuentro entre los españoles comandados por Hernán Cortés y las poblaciones originarias, hace más de cinco siglos, en México se han presentado debates sobre la forma de gobierno y la organización del poder que debía existir, los cuales muchas veces han terminado en guerras intestinas e invasione de potencias extranjeras. Los años del siglo XIX fueron definidores para estructurar un país federal y republicano como existe hasta la fecha. La lucha de los conservadores contra los liberales y la de los centralistas contra los federalistas dan cuenta de ello. Más aún, los intentos monárquicos fallidos: el primero, encabezado por Agustín de Iturbide apenas lograda la independencia nacional y, después, el efímero imperio de Maximiliano de Habsburgo. Ambos son muestra clara de la ausencia de consensos en torno a la idea fracturada de país, a la que hay que agregar las invasiones estadounidense y francesa.
Dos calamitosos en el inicio de la revolución de independencia en Zacatecas
Authors: Burciaga Campos José Arturo 
Published: September 2024

En este texto se da cuenta las vicisitudes de dos personajes con influencia en el inicio de la revolución de independencia en la región de San Luis Potosí y Zacatecas de la Nueva España. Sus correrías los hicieron famosos pero denostados y calificados, Rafael Iriarte como traidor a la causa insurgente y Francisco Álvarez, realista, como cruel y sanguinario. El destino de los dos fue muy diferente. Iriarte fue fusilado tempranamente en el proceso de revolución y Álvarez sobrevivió más allá de la consumación de independencia. En esta investigación son analizadas las actuaciones de ambos personajes y su influencia en los inicios de la guerra en el centro norte novohispano.
Derramas y conflictos en las cofradías de indios en la Provincia de Tlaxcala, Siglos XVII y XVIII
Authors: Rodríguez López Emmanuel 
Published: September 2024

Las cofradías de naturales en la provincia de Tlaxcala, durante la colonia, fueron un espacio de maniobra colectiva de la población indígena frente al sistema español, cuyo análisis permite apreciar conflictos y tensiones así como la capacidad negociadora de los indios frente a ese sistema. Su relevancia fue acorde a su solvencia económica, y la administración de sus recursos estuvo marcada por los embates de intereses españoles, la intervención de la autoridad eclesiástica y los conflictos en su interior. No obstante, la capacidad negociadora de esta corporación indígena fue lo suficientemente fuerte para mantener cierto grado de autonomía frente a la secularización de las parroquias y el reformismo borbónico-episcopal.
Misiones jesuitas de frontera: el caso de Maynas
Authors: Jiménez Gómez Ismael 
Published: September 2024

La presente ponencia tiene el objetivo de revisar algunas estrategias que los padres de la Compañía de Jesús tuvieron que desarrollar en el proceso evangelizador al interior del conjunto misional de Maynas, que estaba ubicado en los actuales territorios de la Amazonía peruana, así como también algunas de las dificultades por las cuales tuvieron que pasar, en su búsqueda por mantener la estabilidad de los pueblos. Para lograr el fin de la investigación, nos valemos de una parte de los estudios historiográficos que se han dedicado a analizar el tema de las misiones jesuitas en la región amazónica. La ponencia se encuentra dividida en cuatro apartados: antecedentes del establecimiento misional, las etapas de desarrollo de los pueblos jesuitas, las estrategias y dificultades para el mantenimiento de los pueblos y las repercusiones que tuvo la expulsión jesuita de 1767 en los pueblos evangelizados. Como resultado de esta investigación, se da cuenta de las estrategias que los religiosos de la Compañía realizaron para llevar a buen puerto la estabilidad y la duración de las misiones amazónicas, así como también se realiza un aporte al estudio del sistema misional jesuítico de la América Colonial.
The Untapped Potential of Narrative as a Tool in Aviation Mental Health and Certification
Authors: Hoffman William R. , McNeil Matthew , Tvaryanas Anthony 
Published: September 2024

INTRODUCTION: Work-related stress is common in pilots, with broad implications, including the potential development of mental health symptoms and sometimes even psychiatric disease. This commentary argues for the use of narrative as a tool to promote preventive health behaviors in pilots and combat misinformation about aeromedical certification related to mental health.
Hoffman WR, McNeil M, Tvaryanas A. The untapped potential of narrative as a tool in aviation mental health and certification. Aerosp Med Hum Perform. 2024; 95(3):165–166.
Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer
Authors: Fu Wenxuan , Chang Xiaomeng , Ye Kun , Zheng Zige , Lai Qianyi , Ge Minyang , Shi Yan 
Published: September 2024

IntroductionProgrammed death-ligand 1 (PD-L1) plays essential roles in the negative regulation of anti-tumor immunity. However, the regulatory mechanisms of PD-L1 expression need further exploration. MORC family CW-type zinc finger 3 (MORC3) is a transcriptional factor that regulates innate immune responses, but the expression and roles of MORC3 in cancers remain largely unknown. The present study explored the expression of MORC3 in cancers at both transcriptional and translational levels.MethodsThe target genes and pathways were analyzed using RNA interference (RNAi), RNA sequencing (RNA-seq), and quantitative real-time polymerase chain reaction (qRT-PCR) technology in head and neck cancer cells. The expression of MORC3 and its target genes were also analyzed in single cancer cells.ResultsMORC3 was significantly downregulated in multiple cancers, including head and neck cancer, and low expression of MORC3 was associated with poor overall survival. MORC3 knockdown significantly increased the expression of many immune-related genes, including interferon (IFN)-associated genes [MX dynamin like GTPase 2 (MX2), interferon induced protein with tetratricopeptide repeats 1 (IFIT1), interferon induced protein with tetratricopeptide repeats 2 (IFIT2), interferon regulatory factor 7 (IRF7), interferon regulatory factor 9 (IRF9), interferon induced protein 44 like (IFI44L), interferon induced transmembrane protein 1 (IFITM1), interferon induced transmembrane protein 3 (IFITM3), interferon induced protein 44 (IFI44), and interferon induced with helicase C domain 1 (IFIH1)]. MORC3 knockdown significantly upregulated PD-L1 and signal transducer and activator of transcription 1 (STAT1) expression. Moreover, the LINC00880 immune-related long non-coding RNA (lnc-RNA) was upregulated by MORC3 knockdown. Silencing LINC00880 attenuated PD-L1 expression. MORC3 knockdown also increased the expression of cellular proliferation-related genes and promoted cancer cell proliferation.ConclusionThe present study demonstrated that MORC3 regulates IFN-associated pathways and is a novel repressor of PD-L1 expression and cancer cell proliferation.
Specific cell subclusters of dental pulp stem cells respond to distinct pathogens through the ROS pathway
Authors: Xu Tiansong , Liu Yangjia , Zhang Wen , Li Murong , Zhang Liqi , Li Xueying , Zhang Yifei , Yue Lin , Li Sha , Lin Ye , Zou Xiaoying , Chen Feng 
Published: September 2024

IntroductionMicrobial pathogens invade various human organs, including the oral cavity. Candida albicans (C.a) and Streptococcus mutans (S.m) served respectively as representative oral pathogenic fungi and bacteria to stimulate dental pulp stem cells (DPSCs) and to screen the DPSC subcluster that specifically responded to fungal infection.MethodsDPSCs were obtained from the impacted third molars of six healthy subjects. Then, cells were mixed and divided into three samples, two of which were stimulated with C.a and S.m, respectively; the third sample was exposed to cell medium only (Ctrl). Single-cell mRNA sequencing analysis of treated DPSCs was performed.ResultsDPSCs were composed of four major clusters of which one, DPSC.7, exhibited unique changes compared to those of other subclusters. The DPSC.7 cell percentage of the C.a sample was twice those of the Ctrl and S.m samples. DPSC.7 cells expressed genes associated with the response to reactive oxygen species (ROS) response. DPSC.7 subgroup cells established characteristic aggregation under the stimulation of different pathogens in UMAP. The MAPK/ERK1/2 and NF-κB pathways were up-regulated, DUSP1/5/6 expressions were suppressed, FOS synthesis was activated, the immune-related pathway was induced, and the levels of cytokines, including IL-6 and CCL2, were up-regulated in DPSC.7 cells when stimulated with C.a.ConclusionsOur study analyzed the cellular and molecular properties of DPSCs infected by oral fungi and bacteria with single-cell RNA sequencing. A subcluster of DPSCs responded specifically to infections with different pathogens, activating the MAPK and NF-κB pathways to induce immune responses via the ROS pathway. This suggests novel treatment strategies for fungal infections.
Weekend screen use of parents and children associates with child language skills
Authors: Tulviste Tiia , Tulviste Jaan 
Published: September 2024

IntroductionThe study examined the relationship between screen time and types of screen activities engaged in by children, mothers, and fathers on weekends, and its association with mother-reported vocabulary and grammatical skills of children aged 2;5 to 4;0.MethodsMothers reported the language skills of 421 children (M age = 38.18 months; SD = 5.73) by the Estonian CDI-III, and the screen use of children, mothers, and fathers by the Screen Time Inventory. We applied Latent Class Analysis (LCA) to analyze the screen time of children, mothers, and fathers, aiming to identify common family screen use profiles.ResultsThe results showed that higher total screen time of children was linked to poorer vocabulary and grammatical skills. None of the screen-based activities that children, mothers, and fathers engaged in, including co-viewing of screens and socializing time, were found to positively relate to language skills. Playing video games was negatively associated with children's language skills, regardless of whether it was the child, mother, or father gaming. LCA identified 3 distinct family screen use profiles (low, moderate, and high users) which differed by parental education, screen-based activities, and children's language skills.DiscussionThe findings underscore the significance of family-based interventions when addressing screen time within the context of child language development.
Maternal immunity shapes biomarkers of germinal center development in HIV‐exposed uninfected infants
Authors: Yin Li , Venturi Guglielmo M. , Barfield Richard , Fischer Bernard M. , Kim-Chang Julie J. , Chan Cliburn , De Paris Kristina , Goodenow Maureen M. , Sleasman John W. 
Published: September 2024

IntroductionHIV-exposed uninfected (HEU) infants exhibit elevated pro-inflammatory biomarkers that persist after birth. However, comprehensive assessments of bioprofiles associated with immune regulation and development in pregnant women with HIV (PWH) and HEU infants has not been performed. Maternal immunity in PWH may be imprinted on their HEU newborns, altering immune bioprofiles during early immune development.MethodsCryopreserved paired plasma samples from 46 HEU infants and their mothers enrolled in PACTG 316, a clinical trial to prevent perinatal HIV-1 transmission were analyzed. PWH received antiretrovirals (ARV) and had either fully suppressed or unsuppressed viral replication. Maternal blood samples obtained during labor and infant samples at birth and 6 months were measured for 21 biomarkers associated with germinal centers (GC), macrophage activation, T-cell activation, interferon gamma (IFN-γ)-inducible chemokines, and immune regulatory cytokines using Mesoscale assays. Pregnant women without HIV (PWOH) and their HIV unexposed uninfected (HUU) newborns and non-pregnant women without HIV (NPWOH) served as reference groups. Linear regression analysis fitted for comparison among groups and adjusted for covariant(s) along with principal component analysis performed to assess differences among groups.ResultsCompared with NPWOH, PWOH displayed higher levels of GC, macrophage, and regulatory biomarkers. PWH compared to PWOH displayed elevated GC, T cell activation, and IFN-γ-inducible chemokines biomarkers at delivery. Similar to their mothers, HEU infants had elevated GC, macrophage, and IFN-γ-inducible chemokines, as well as elevated anti-inflammatory cytokines, IL-10 and IL-1RA. Across all mother/newborn dyads, multiple biomarkers positively correlated, providing further evidence that maternal inflammation imprints on newborn bioprofiles. By 6 months, many HEU biomarkers normalized to levels similar to HUU infants, but some GC and inflammatory biomarkers remained perturbed. Bioprofiles in PWH and HEU infants were similar regardless of the extent of maternal viral suppression by ARV.ConclusionsGC immune pathways are perturbed in HEU newborns, but immune regulatory responses down regulate inflammation during early infancy, indicating a transient inflammatory effect. However, several GC biomarkers that may alter immune development remain perturbed.
Whole transcriptome landscape in HAPE under the stress of environment at high altitudes: new insights into the mechanisms of hypobaric hypoxia tolerance
Authors: Li Qiong , Fang Fujin , Yang Chuanli , Yu Dong , Gong Qianhui , Shen Xiaobing 
Published: September 2024

BackgroundHigh altitude pulmonary edema (HAPE) is an idiopathic, noncardiogenic form of pulmonary edema that occurs at high altitudes. It is characterized by a severe clinical course and carries a significant mortality risk. Despite its clinical relevance, the molecular mechanisms underlying HAPE are not well understood.MethodsWe conducted whole-transcriptome RNA sequencing on blood samples from 6 pairs of HAPE patients and healthy controls to identify differentially expressed (DE) mRNAs, miRNAs, circRNAs, lncRNAs, along with alternative splicing (AS) events, gene fusions, and novel transcripts. To explore the regulatory dynamics, we constructed ceRNA networks and analyzed immune cell infiltration patterns, further annotating the biological functions of these transcripts. For empirical validation, we selected five circRNAs from the ceRNA network and conducted RT-qPCR on 50 paired samples. Additionally, we assessed the correlations between circRNA expression levels and clinical data to evaluate their diagnostic potential.ResultsWe observed 2,023 differentially expressed mRNAs (DEmRNAs), 84 DEmiRNAs, 200 DEcircRNAs, and 3,573 DElncRNAs. A total of 139 ‘A3SS’ events, 103 ‘A5SS’ events, 545 ‘MXE’ events, 14 ‘RI’ events, and 1,482 ‘SE’ events were identified in the AS events analysis between the two groups. Two ceRNA networks were constructed. T cells, follicular helper, and Macrophages M1 cells exhibited the strongest positive correlation (R=0.82), while naive B cells and memory B cells demonstrated the strongest negative correlation (R=-0.62). In total, the expression of three circRNAs was significantly different in a larger cohort. Hsa_circ_0058497, hsa_circ_0081006, and hsa_circ_0083220 demonstrated consistent with the RNA sequencing results. These three circRNAs strongly correlate with clinical indicators and exhibit potential as diagnostic biomarkers. Finally, we verified five genes (CXCR4, HSD17B2, ANGPTL4, TIMP3, N4BP3) that were differentially expressed in endothelial cells under normoxia and hypoxia through bioinformatics and RT-qPCR analyses.ConclusionThis study elucidates the differential expression of coding and non-coding RNAs (ncRNAs) in HAPE, identifies new transcripts and genes, and enhances our understanding of the transcriptional characteristics of HAPE. Moreover, it highlights the potential role of circRNAs in advancing the diagnosis and treatment of HAPE.
Co-creation in healthcare and research to improve service delivery for young people with chronic pain
Authors: Berryman Carolyn , Starr Tegan , Ferencz Nicki , Coakley Rachael 
Published: September 2024

IntroductionThe process of co-creation can enable more effective, agile and integrated healthcare solutions achieving outcomes that effectively translate to healthcare delivery. Collaborative knowledge generation is particularly important in fields such as pediatric chronic pain where there is a complex interplay between biological, social, environmental, emotional, familial and school factors. The co-creation initiative described here was designed to amplify the voices of youth with chronic pain and their families and a variety of key stakeholders and generate novel approaches to the management of chronic pediatric pain in the setting of the South Australian Pediatric Chronic Pain Service.MethodsStakeholders who were identified as influential in this ecosystem were allocated to 6 groups. A skilled facilitator co-prepared and delivered the workshop, engaging participants in three structured activities. Firstly, the challenges to service delivery were outlined, followed by the groups discussing what is currently working. The second activity involved lateral thinking without restrictions on time, resources or system to generate solutions to the key challenges presented. Finally, stakeholders were asked to agree on a generated solution from Activity 2 and build a case for actionable implementation of this solution. Data were summarised by the workshop facilitator and reflexive thematic analysis was used for coding and generating themes.ResultsFrom Activity 1, six themes collectively demonstrated that stakeholders valued many of the existing strengths of the service delivery, but some areas such as pain education was undervalued. Activity 2 generated solutions from high-level ideas to more day-to- day management strategies. Each of six groups generated unique solutions to an identified challenge for Activity 3.DiscussionEngaging a wide variety of stakeholders in collaborative knowledge generation successfully provided the South Australian Pediatric Chronic Pain Service with a variety of novel, scalable solution across the healthcare continuum. Equally important is that this initiative helped to raise awareness about the complex issues faced in pediatric chronic pain care and helped to establish new partnerships that have led to enhanced service delivery.
Association of white matter hyperintensities with cognitive decline and neurodegeneration
Authors: Li Tao-Ran , Li Bai-Le , Xu Xin-Ran , Zhong Jin , Wang Tai-Shan , Liu Feng-Qi ,   the Alzheimer’s Disease Neuroimaging Initiative
Published: September 2024

BackgroundThe relationship between white matter hyperintensities (WMH) and the core features of Alzheimer’s disease (AD) remains controversial. Further, due to the prevalence of co-pathologies, the precise role of WMH in cognition and neurodegeneration also remains uncertain.MethodsHerein, we analyzed 1803 participants with available WMH volume data, extracted from the ADNI database, including 756 cognitively normal controls, 783 patients with mild cognitive impairment (MCI), and 264 patients with dementia. Participants were grouped according to cerebrospinal fluid (CSF) pathology (A/T profile) severity. Linear regression analysis was applied to evaluate the factors associated with WMH volume. Modeled by linear mixed-effects, the increase rates (Δ) of the WMH volume, cognition, and typical neurodegenerative markers were assessed. The predictive effectiveness of WMH volume was subsequently tested using Cox regression analysis, and the relationship between WMH/ΔWMH and other indicators such as cognition was explored through linear regression analyses. Furthermore, we explored the interrelationship among amyloid-β deposition, cognition, and WMH using mediation analysis.ResultsHigher WMH volume was associated with older age, lower CSF amyloid-β levels, hypertension, and smoking history (all p ≤ 0.001), as well as cognitive status (MCI, p &lt; 0.001; dementia, p = 0.008), but not with CSF tau levels. These results were further verified in any clinical stage, except hypertension and smoking history in the dementia stage. Although WMH could not predict dementia conversion, its increased levels at baseline were associated with a worse cognitive performance and a more rapid memory decline. Longitudinal analyses showed that baseline dementia and positive amyloid-β status were associated with a greater accrual of WMH volume, and a higher ΔWMH was also correlated with a faster cognitive decline. In contrast, except entorhinal cortex thickness, the WMH volume was not found to be associated with any other neurodegenerative markers. To a lesser extent, WMH mediates the relationship between amyloid-β and cognition.ConclusionWMH are non-specific lesions that are associated with amyloid-β deposition, cognitive status, and a variety of vascular risk factors. Despite evidence indicating only a weak relationship with neurodegeneration, early intervention to reduce WMH lesions remains a high priority for preserving cognitive function in the elderly.