bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between underestimation of tumour size by imaging and incomplete excision in breast-conserving surgery for breast cancer
Authors: Dixon J M , Newlands C , Dodds C , Thomas J , Williams L J , Kunkler I H , Bing A , Macaskill E J 
Published: May 2016

Abstract

Background
Completeness of excision is the most important factor influencing local recurrence after breast-conserving surgery (BCS). The aim of this case–control study was to determine factors influencing incomplete excision in patients undergoing BCS.

Methods
Women with invasive breast cancer treated by BCS between 1 June 2008 and 31 December 2009 were identified from a prospectively collected database in the Edinburgh Breast Unit. The maximum size of the tumour, measured microscopically, was compared with the size estimated before operation by mammography and ultrasound imaging. A multivariable analysis was performed to investigate factors associated with incomplete excision.

Results
The cohort comprised 311 women, of whom 193 (62·1 per cent) had a complete (CE group) and 118 (40·7 per cent) an incomplete (IE group) excision. Mammography underestimated tumour size in 75·0 per cent of the IE group compared with 40·7 per cent of the CE group (P &lt; 0·001). Ultrasound imaging underestimated tumour size in 82·5 per cent of the IE group compared with 56·5 per cent of the CE group (P &lt; 0·001). The risk of an incomplete excision was greater when mammography or ultrasonography underestimated pathological size: odds ratio (OR) 4·38 (95 per cent c.i. 2·59 to 7·41; P &lt; 0·001) for mammography, and OR 3·64 (2·03 to 6·54; P &lt; 0·001) for ultrasound imaging. For every 1-mm underestimation of size by mammography and ultrasonography, the relative odds of incomplete excision rose by 10 and 14 per cent respectively.

Conclusion
Underestimation of tumour size by current imaging techniques is a major factor associated with incomplete excision in women undergoing BCS.
Lipotransfer for radiation-induced skin fibrosis
Authors: Kumar R , Griffin M , Adigbli G , Kalavrezos N , Butler P E M 
Published: May 2016

AbstractBackgroundRadiation-induced fibrosis (RIF) is a late complication of radiotherapy that results in progressive functional and cosmetic impairment. Autologous fat has emerged as an option for soft tissue reconstruction. There are also sporadic reports suggesting regression of fibrosis following regional lipotransfer. This systematic review aimed to identify cellular mechanisms driving RIF, and the potential role of lipotransfer in attenuating these processes.MethodsPubMed, OVID and Google Scholar databases were searched to identify all original articles regarding lipotransfer for RIF. All articles describing irradiated fibroblast or myofibroblast behaviour were included. Data elucidating the mechanisms of RIF, role of lipotransfer in RIF and methods to quantify fibrosis were extracted.ResultsNinety-eight studies met the inclusion criteria. A single, definitive model of RIF is yet to be established, but four cellular mechanisms were identified through in vitro studies. Twenty-one studies identified connective tissue growth factor and transforming growth factor β1 cytokines as drivers of fibrotic cascades. Hypoxia was demonstrated to propagate fibrogenesis in three studies. Oxidative stress from the release of reactive oxygen species and free radicals was also linked to RIF in 11 studies. Purified autologous fat grafts contain cellular and non-cellular properties that potentially interact with these processes. Six methods for quantifying fibrotic changes were evaluated including durometry, ultrasound shear wave elastography, thermography, dark field imaging, and laser Doppler and laser speckle flowmetry.ConclusionUnderstanding how lipotransfer causes regression of RIF remains unclear; there are a number of new hypotheses for future research.
Comparative evaluation of four multi‐label classification algorithms in classifying learning objects
Authors: Aldrees Asma , Chikh Azeddine 
Published: May 2016

ABSTRACTWith the increasing number of learning objects (LOs), the possibility of their fast and effective retrieving and storing has become a more critical issue. The classification of LOs enables users to search for, access, and reuse them in an effective and efficient way. In this article, the multi‐label learning approach is represented for classifying and ranking multi‐labeled LOs, whereas each LO might be associated with multiple labels as opposed to a single‐label approach. A comprehensive overview of the common fundamental multi‐label classification algorithms and metrics will be discussed. In this article, a new multi‐labeled LOs dataset will be created and extracted from ARIADNE Learning Object Repository. We experimentally train four effective multi‐label classifiers on the created LOs dataset and then, assess their performance based on the results of 16 evaluation metrics. The result of this article will answer the question of; what is the best multi‐label classification algorithm for classifying multi‐labeled LOs? © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:651–660, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21743
BET and BRAF inhibitors act synergistically against BRAF‐mutant melanoma
Authors: Paoluzzi Luca , Hanniford Douglas , Sokolova Elena , Osman Iman , Darvishian Farbod , Wang Jinhua , Bradner James E. , Hernando Eva 
Published: May 2016

AbstractDespite major advances in the treatment of metastatic melanoma, treatment failure is still inevitable in most cases. Manipulation of key epigenetic regulators, including inhibition of Bromodomain and extra‐terminal domain (BET) family members impairs cell proliferation in vitro and tumor growth in vivo in different cancers, including melanoma. Here, we investigated the effect of combining the BET inhibitor JQ1 with the BRAF inhibitor Vemurafenib in in vitro and in vivo models of BRAF‐mutant melanoma. We performed cytotoxicity and apoptosis assays, and a xenograft mouse model to determine the in vitro and in vivo efficacy of JQ1 in combination with Vemurafenib against BRAF‐mutant melanoma cell lines. Further, to investigate the molecular mechanisms underlying the effects of combined treatment, we conducted antibody arrays of in vitro drug‐treated cell lines and RNA sequencing of drug‐treated xenograft tumors. The combination of JQ1 and Vemurafenib acted synergistically in BRAF‐mutant cell lines, resulting in marked apoptosis in vitro, with upregulation of proapoptotic proteins. In vivo, combination treatment suppressed tumor growth and significantly improved survival compared to either drug alone. RNA sequencing of tumor tissues revealed almost four thousand genes that were uniquely modulated by the combination, with several anti‐apoptotic genes significantly down‐regulated. Collectively, our data provide a rationale for combined BET and BRAF inhibition as a novel strategy for the treatment of melanoma.
ACCLMesh: curvature‐based navigation mesh generation
Authors: Berseth Glen , Kapadia Mubbasir , Faloutsos Petros 
Published: May 2016

AbstractThe proposed method computes a navigation mesh for arbitrary and dynamic 3D environments based on curvature and is robust and efficient. This method addresses a number of known limitations in state‐of‐the‐art techniques to produce navigation meshes that are tightly coupled to the original geometry, incorporate geometric details that are crucial for movement decisions, can robustly handle complex surfaces and can efficiently repair the navigation mesh to accommodate dynamically changing environments. The method is integrated into a standard navigation and collision avoidance system to simulate thousands of agents on complex 3D surfaces in real time. Copyright © 2016 John Wiley & Sons, Ltd.
Support Functionalization with a Phosphine‐Containing Hyperbranched Polymer: A Strategy to Enhance Phosphine Grafting and Metal Loading in a Hydroformylation Catalyst
Authors: Garcia Marco A. S. , Heyder Rodrigo S. , Oliveira Kelley C. B. , Costa Jean C. S. , Corio Paola , Gusevskaya Elena V. , dos Santos Eduardo N. , Bazito Reinaldo C. , Rossi Liane M. 
Published: May 2016

AbstractWe present the design of a hydroformylation catalyst through the immobilization of air‐stable Rh nanoparticles (NPs) on a magnetic support functionalized with a hyperbranched polymer that bears terminal phosphine groups. The catalyst modification with the hyperbranched polymer improved the metal–support interaction, the metal loading, and the catalytic activity. The catalyst was active for the hydroformylation of natural products, such as estragole, and could be used in successive reactions with negligible metal leaching. The phosphine grafting played a key role in the recyclability of Rh NPs under hydroformylation conditions. The catalytic activity was maintained in successive reactions, even if the catalyst was exposed to air during each recovery procedure. The modification of the support with hyperbranched polyester allowed us either to increase the number of Rh active species or to obtain more active Rh species on the catalyst surface.
ChemInform Abstract: Multinuclear NMR Characterization of Anionic Clusters of the Main‐Group Elements Ge, Sn, Sb, Tl, Pb, and Bi in Nonaqueous Solution.
Authors: WILSON W. L. , RUDOLPH R. W. , LOHR L. L. , TAYLOR R. C. , PYYKKOE P. + 
Published: May 2016

AbstractClusters, generated by dissolving their alloys with alkali metals in liquid ethylenediamine (e.g.
ChemInform Abstract: Structure and Magnetic Properties of PrLiGe, TbLiGe, DyLiGe, YbLiGe, and YbLi‐ Bi.
Authors: GRUND I. , ZWIENER G. , SCHUSTER H.‐U. 
Published: May 2016

AbstractThe title compounds ALiGe (A: Pr, Tb, Dy, Yb) are prepared starting from the elements (Ta crucibles; Li excess; 850 K (5‐12 h), then 1070‐ l 120 K (3‐15 h)).
ChemInform Abstract: Temperature Dependence of the Rate Constant for the Reaction OH + H2S in He, N2, and O2.
Authors: LIN Y.‐L. , WANG N.‐S. , LEE Y.‐P. 
Published: May 2016

AbstractThe rate constants of the title reaction have been measured in the temp. range 245‐450 K using the discharge‐flow‐resonance fluorescence technique.
ChemInform Abstract: Preparation of Solid Catalysts for Vapor‐Phase Decomposition of Carbonyl Sulfide.
Authors: AKIMOTO M. , SUTO H. , NIIYAMA H. 
Published: May 2016

AbstractComparison of the catalytic activity and selectivity of a series of Al2O3 Catalysts in COS decomposition (reactions Aand B) demonstrate that electron‐donating sites catalyze reaction Awhereas Lewis acid sites catalyze reaction B. CaO Catalysts are prepared by thermal decomposition of CaCO3 and their catalytic activity is related to their amount of electron‐donating sites.
ChemInform Abstract: Trigonal Planar Coordinated Platinum: Preparation and Crystal Structure of SrPtAs (Sb), BaPtP (As, Sb), SrPtxP2‐x, SrPtxAs0.90, and BaPtxAs0.90.
Authors: WENSKI G. , MEWIS A. 
Published: May 2016

AbstractThe compounds (I)‐(VII) are prepared by reaction of the elements in corundum crucibles at 950‐1050°C (l ‐2 weeks).
ChemInform Abstract: Condensed Ring Systems. Part 17. Propellanes with Benzene‐Dewar‐Benzene Structure
Authors: WEINGES K. , KLEIN J. , SIPOS W. , GUENTHER P. + , HUBER‐PATZ U. , RODEWALD H. , DEUTER J. , IRNGARTINGER H. 
Published: May 2016

AbstractCrystal and Molecular Structure of l′,8′:3,5‐Naphtho15.2.2lpropella‐ 3,8,l0‐triene.
ChemInform Abstract: Complexation of Gold(I) Thiomalate (′Myocrisin′) with 1,3‐Diazinane‐2‐thione in Aqueous Solution Followed by 13C Nuclear Magnetic Resonance Spectroscopy.
Authors: ISAB A. A. 
Published: May 2016

AbstractIt is shown that the anti‐arthritic drug gold(I) thiomalate forms a l :l complex with 1,3‐diazinane‐2‐thione (L) at pH 7.2.
ChemInform Abstract: Ionization and Electroreduction of Some Benzthiazin‐4‐one Azodyes.
Authors: ABED N. M. , NASHED B. , FAHMY H. M. , ABDEL AZZEM M. 
Published: May 2016

AbstractThe pKa‐values of (I) are highly dependent on the nature of the substituent on the arylazo moiety.
ChemInform Abstract: SRN1 Reactions of Halocyclopropanes with Benzenethiolate Ion.
Authors: MEIJS G. F. 
Published: May 2016

AbstractDie Umsetzungen zahlreicher gem‐Dibromcyclopropane (I) mit Thiophenolat (II) zu den Verbindungen (III)‐(V) werden untersucht.
ChemInform Abstract: Intramolecular Diels‐Alder Additions of Benzynes to Furans.
Authors: BEST W. M. , WEGE D. 
Published: May 2016

AbstractThe synthetic strategy of constfucting heterocycles of type (II) by intramolecular Diels‐Alder reac‐ tion of benzynes (I) is explored.
ChemInform Abstract: Phenyl Isothiocyanate‐Mediated Cyclocondensation of Hippuric Acid in the Presence of Salicylaldehyde/o‐Hydroxyacetophenone.
Authors: ASHARE R. , MUKERJEE A. K. 
Published: May 2016

AbstractPhenyl Isothiocyanate‐Mediated Cyclocondensation of Hippuric Acid in the Presence of Salicylaldehyde/o‐Hydroxyacetophenone.
ChemInform Abstract: Pummerer‐Type Reaction of α‐Acylsulfides Using Phenyl Iodosyl Bis(trifluoroacetate).
Authors: TAMURA Y. , YAKURA T. , SHIROUCHI Y. , HARUTA J. 
Published: May 2016

AbstractBei der Behandlung des Methylthioacetanilids (I) mit Phenyliodosyl‐bis‐(trifluoracetat) (PIFA) entsteht direkt das Pummerer‐Umlagerungsprodukt (II) des (I) entsprechenden Sulfoxids (III).
ChemInform Abstract: Rearrangement of Polybromoalkyl Radicals with 1,5‐ and 1,6‐Hydrogen Migration in the Reduction of 1,1,1,3‐Tetrabromoheptane.
Authors: VASIL'EVA T. T. , GERMANOVA L. F. , NELYUBIN B. V. , FREIDLINA R. KH. 
Published: May 2016

AbstractAus der im Titel genannten Verbindung (I) entsteht unter dem katalytischen Einfluß von Eisenpentacarbonyl (II) mit Triethylsilan (III) das Tribromid (IV).
ChemInform Abstract: Asymmetric Induction in Intramolecular Ene Reactions of 1,7‐Dienes.
Authors: TIETZE L. F. , BEIFUSS U. 
Published: May 2016

AbstractDas Dien (I) reagiert mit Zinkbromid zum Isomeren (III) und Cyclisierungsprodukt (II).
ChemInform Abstract: A Novel Methyl Migration in the Claisen Rearrangement of 3‐(1,1‐Dimethylprop‐ 2‐ynyloxy)‐4‐methylxanthone and 7‐(1,1‐Dimethylprop‐2‐ynyl‐ oxy)‐8‐methylisoflavone.
Authors: JOSHI S. C. , PATEL G. N. , TRIVEDI K. N. 
Published: May 2016

AbstractDie Claisen‐Umlagerung des Xanthons (I) in siedendem Dimethylanilin führt unter Methylgruppenwanderung zum Furanoxanthon (II).
ChemInform Abstract: Catalytic Isomerization of Water‐Soluble Quadricyclane to Norbornadiene Derivatives Induced by Cobalt‐Porphyrin Complexes.
Authors: MARUYAMA K. , TAMIAKI H. 
Published: May 2016

AbstractWasserlösliche Quadricyclan‐carbonsäuren (I), deren Herstellung nach bekannten Verfahren beschrieben ist, isomerisieren bei Zusatz des Co‐ Katalysators (II) unter starker Wärmeentwicklung zu den Norbornadienen (III); in gleicher Weise reagieren die Dicarbonsäurederivate (IV) zu den Norbornadienen (V).
ChemInform Abstract: Photochemical Reaction of N‐Methylnaphthalene‐1,8‐dicarboximide with Alkenes, Dienes, and Furans.
Authors: KUBO Y. , SUTO M. , TOJO S. , ARAKI T. 
Published: May 2016

AbstractThe irradiation of the title compound (II) in the presence of the alkenes (Ia)‐(Ig) [(Ih) gives no reaction], the dienes (VII) and (IX) and the furans (XII) is examined.
ChemInform Abstract: The Photochemical 1,5‐Benzoyl Migration in 2,2‐Diaryl‐1,4,4‐triphenyl‐3‐azabut‐ 3‐en‐1‐ones.
Authors: ARMESTO D. , GALLEGO M. G. , HORSPOOL W. M. , PEREZ‐OSSORIO R. 
Published: May 2016

AbstractThe imines (I) which are obtained by condensation of the corresponding ketones with diphenylmethylamine under reducing conditions, react with NaH to form the corresponding anions, which are quenched by benzoyl chloride to yield (II).
ChemInform Abstract: Photoinduced Reactions. Part 84. Photochemistry of the Phthalimide System.
Authors: TAKECHI H. , MACHIDA M. , KANAOKA Y. 
Published: May 2016

AbstractThe photoreaction of the phtha limides (I) causes C ‐ Cbond formation between one of the carbon atoms of the two carbonyl groups of the imide moiety and the carbon atom neighbouring the amide nitrogen atom to yield the cyclized products ( II).
ChemInform Abstract: Ultrasound in Organic Synthesis. Part 9. Further Results for the Bouveault Reaction.
Authors: EINHORN J. , LUCHE J. L. 
Published: May 2016

AbstractBei der Bouveault‐Reaktion von Brombenzol (I) mit Lithium und N‐Formyl‐ Verbindungen (III) erhält man unter Ultraschall‐Behandlung in verschiedenen Lösungsmitteln (IV) unterschiedliche Anteile der Addukte (V), die zu Benzaldehyd (VI) hydrolysiert werden.
ChemInform Abstract: Synthesis of 2,2,6,6‐Tetramethyl‐4‐amino‐N‐(alkylmaleimide)‐1‐oxylpiperidines.
Authors: BONDAREV G. N. , BURZINA T. S. , KRASOTSKAYA G. I. , ISAEVA‐IVANOVA L. S. , KATSHURIN A. M. , KEINER A. R. 
Published: May 2016

AbstractDie zur Spinmarkierung von Biopolymeren verwendeten Nitroxyle (IV) werden auf dem angegebenen Weg aus den Nitroxylen (I) dargestellt und an Serumalbumin auf ′ ihre Verwendbarkeit getestet.
ChemInform Abstract: Oxidative Decomposition of Tertiary Alcohols in Basic Medium.
Authors: ARTAMKINA G. A. , GRINFEL'D A. A. , BELETSKAYA I. P. 
Published: May 2016

AbstractDie Zersetzung des tertiären Alkohols (I) mit KOH in Dimethoxyethan liefert im Sauerstoff‐freien Milieu neben Aceton (III) Dichlorcarben, das mit Cyclohexen (II) zu Dichlornorcaran (IV) abgefangen wird.
ChemInform Abstract: Chemical Reduction of the Radiosensitizer Misonidazole by Zinc or Glucose.
Authors: GATTAVECCHIA E. , TONELLI D. 
Published: May 2016

AbstractIn order to examine the formation of secondary products in the reduction of the title compound (II), the reaction is carried out with Zn dust in aqueous NH4Cl or under more alkaline conditions and leads to the main products (I) or (III), respectively.
ChemInform Abstract: Chromium(II) Reduction of Trichloromethyl Carbinols and Their Corresponding Ethers: One‐Step Synthesis of Z‐Vinyl Chlorides.
Authors: WOLF R. , STECKHAN E. 
Published: May 2016

AbstractThe title reaction A) of (I), (V) and (VIII) readily yields the products ähown in the scheme.
ChemInform Abstract: Alkylation of Schiff Bases by Halides of the Propargyl Type.
Authors: REMIZOVA L. A. , SHUSTROVA T. A. , FAVORSKAYA I. A. 
Published: May 2016

AbstractThe reaction between diphenylmethylenebenzylamine (I) and the p‐ropargyl bromides (II) under phase transfer conditions affords the prim. alkynylphenylamines (III) as the sole products.
ChemInform Abstract: Addition of Aldehydes to Activated Double Bonds. Part 38. Some Consecutive Reactions of α,β‐Unsaturated 1,4‐Diketones.
Authors: STETTER H. , HILLBOLL G. , SKOBEL S. 
Published: May 2016

AbstractAcid‐catalyzed cyclization of the (E,Z) dione (I) yields the bicyclic enol ether (II).
ChemInform Abstract: Synthesis of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals.
Authors: NIITSU M. , SAMEJIMA K. 
Published: May 2016

AbstractDie symmetrischen (VI) und unsymmetrischen linearen Pentaamine (X) werden auf bekannten Wegen, wie im Formelschema skizziert, hergestellt.
ChemInform Abstract: Ozonolysis of Alkenes and a Study of the Reactions of Polyfunctional Compounds.
Authors: ODINOKOV V. N. , IGNATYUK V. K. , KRIVONOGOV V. P. , TOLSTIKOV G. A. 
Published: May 2016

AbstractThe ozonolysis of the caoutchouc SKI‐3 (I) yields a mixture of the w‐acetylpolyenic aldehydes (II), with Z‐configuration.
ChemInform Abstract: A Facile Allylic 1,3‐Rearrangement of a Sulfonyl Group and Its Application to a Synthesis of α,β‐Unsaturated Ketones.
Authors: OGURA K. , IIHAMA T. , KIUCHI S. , KAJIKI T. , KOSHIKAWA O. , TAKAHASHI K. , IIDA H. 
Published: May 2016

AbstractVerbindung (I) wird stufenweise zu (IV) substituiert und dann über SiOz zu (V) umgelagert.
ChemInform Abstract: Reaction of Polyfluoroalkylfluorosulfates with N‐Nucleophiles.
Authors: FOKIN A. V. , RAPKIN A. I. , TATARINOV A. S. , TITOV V. A. , STYDNEV YU. N. 
Published: May 2016

AbstractDie Polyfluoralr kylfluorsulfonsäureester (I) setzen sich mit den Stickstoffbasen (II) zu den entsprechenden Amiden und Hydraziden (III) um.
ChemInform Abstract: Conjugated ω‐Dimethylaminothioaldehydes as a Result of the Reaction between Aminals and Thioacetoacetic Ester.
Authors: KRASNAYA ZH. A. 
Published: May 2016

AbstractDie w‐Dimethylaminoaminale (I) bzw. (V) reagieren mit dem Thioacetylessigsäureester (II) zu den konjugierten Dimethylaminothioaldehyden (III) und (VI) neben dem Aminobutensäureester (IV).
ChemInform Abstract: Stereochemistry of Oxidative Deiodination Leading to Formation of Covalent Perchlorates.
Authors: ZEFIROV N. S. , ZHDANKIN V. V. , KOZ'MIN A. S. 
Published: May 2016

AbstractAus den polycyclischen Iodverbindungen (I) erhält man bei der Oxidation in Gegenwart von Lithium‐perchlorat unter Konfigurationsumkehr die Perchlorate (II), wobei gleichzeitig eine Oxidation der Thioether‐Gruppierung in (Ia) zum Sulfoxid und zum Sulfon erfolgt.
ChemInform Abstract: Reactions with Betaines. Part 21. On the Formation of Formazyl Compounds by Coupling of S‐Betaines with 4‐Nitrophenyldiazonium Tetrafluoroborate.
Authors: ZIEGLER E. , WITTMANN H. 
Published: May 2016

AbstractThe diazonium tetrafluoroborate (I) reacts with the betaines (II) or (IV) in acetic acid to yield the formazyl Compounds (III) or (V).
ChemInform Abstract: Reaction of N,N‐Dimethyl‐N′‐thiobenzoylformamidine and N,N‐Dimethyl‐N′‐phenylthiocarbamoylformamidine with N‐Arylbenzimidoyl Chlorides.
Authors: BARUAH P. D. , ROY G. , SATSANGI R. , MAHAJAN M. P. 
Published: May 2016

AbstractWhile the reaction of the chlorides (I) with the formamidine (II) yields the sulfides (III), the reaction with the formamidine (IV) furnishes the products (V) and/or (VI) depending on the (I) used.
ChemInform Abstract: Thioketone‐S‐oxides by [2 + 2] Cycloaddition of Ynamines with N‐Sulfinyl‐tosylamide.
Authors: KOSACK S. , HIMBERT G. , MAAS G. 
Published: May 2016

AbstractThe title reaction yields the heterocyclic intermediates (III), which isomerize to give either E or Zproducts (IV) [E‐(IVc) converts to Z‐(IVc) in solution].
ChemInform Abstract: Reductive Transformations. Part 7. Poly(anthrylenetrimethylenes) and 9,10‐Bridged Anthracenes by Reductive Alkylation.
Authors: BENDER D. , UNTERBERG H. , MUELLEN K. + 
Published: May 2016

AbstractThe monoanion (III) obtained by deprotonation of (II) reacts with (I) to provide either (IV) or (V) (experimental details and yields in some cases not given).
ChemInform Abstract: Cycloaddition Reactions of Citral Dienamines with 1,4‐Quinones.
Authors: EKKUNDI V. S. , TRIVEDI G. K. 
Published: May 2016

AbstractThe cycloaddition reactions of the dienamines (I) with the quinones (II), (VI) and (IX) yield the anthraquinones shown in the scheme [yields given in g for the mixture (V)/(X′)].
ChemInform Abstract: Reaction of Aldonitrones with Copper Acetylide: Synthesis of Some Novel β‐Lactams.
Authors: DUTTA D. K. , BORUAH R. C. , SANDHU J. S. 
Published: May 2016

AbstractReaction of the nitrones (Ia) with copper acetylide, prepared in situ from phen ylacetylene (IV) and cuprous Chloride, yields mixtures of the trans‐β‐lactams (II) and the cis‐lactams (IIIa).
ChemInform Abstract: Studies in Ranitidine Chemistry: An Unusual O→N Methyl Migration.
Authors: HERZIG J. , ANTEBI A. , NUDELMAN A. , GOTTLIEB H. E. 
Published: May 2016

AbstractRanitidin (IV), ein H2‐Rezeptor‐Antagonist, wird aus (I) und (II) über die Zwischenstufe (III) hergestellt.
ChemInform Abstract: Selective Demethylative Cyclisation of 2‐Methoxy‐allylbenzenes.
Authors: DEVAKUMAR C. , MUKERJEE S. K. 
Published: May 2016

AbstractWhen the me‐thoxy‐allylbenzenes (I), (III), (VI) and (IX) are treated according to method A), selective demethylative cyclisation takes place yielding dihydrobenzofurans.
ChemInform Abstract: Studies on Pyrazolines: Synthesis, Pyrolysis and Reactivity of Some 3‐Aroyl‐4‐aryl‐Δ2‐pyrazolines.
Authors: RAO C. B. , RAJU G. V. S. , RAJU P. V. N. 
Published: May 2016

AbstractCycloadditon of the chalcones (I) with diazomethane (II) yields the title compounds (III).
ChemInform Abstract: Possible Anthelminthic Agents: Syntheses of Methyl 5(6)‐Substituted‐benzimidazole‐ 2‐carbamates.
Authors: AKHTAR M. S. , SETH M. , BHADURI A. P. 
Published: May 2016

AbstractThe compounds (III), (IV), (VII), (IX), (XII) and (XV) are synthesized as indicated in the scheme and evaluated for their anthelminthic activity.