bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design and manufacture of equine hand prosthesis by additive manufacturing
Authors: Benegra Denadai Bruno , Foggiatto José Aguiomar , Triches Dornbusch Peterson , Pioli Torres Maria Fernanda , Luersen Marco Antônio 
Published: September 2024

Purpose
This paper aims to design and manufacture an equine hand prosthesis using additive manufacturing, with an estimated useful life of one year. This approach offers a fast and affordable manufacturing alternative while ensuring the horse's safety, comfort and functionality.

Design/methodology/approach
The ground reaction force and the frequency of a horse’s walking were obtained from the literature. Mechanical tests were conducted on specimens with different manufacturing directions to determine the mechanical properties of the printed material. Finite element simulations, along with fatigue equations were used to design a geometry that respected the stress constraints. Subsequently, a prototype was manufactured in thermoplastic polyurethane using additive manufacturing technique.

Findings
With the aid of the proposed methodology, a new low-cost equine hand prosthesis is developed, and a prototype is manufactured. And in accordance with the design requirements, this prosthesis is intended to exhibit proper durability.

Social implications
This work presents an alternative way for horses facing amputation, offering a solution where euthanasia can be avoided through the use of a prosthesis to replace a part of the amputated limb. This approach could not only extend the reproductive life of matrices with high commercial value but also preserve the lives of animals with sentimental value to the owner.

Originality/value
To the best of the authors' knowledge, this is the first study of an equine hand prosthesis model designed for and manufactured by additive manufacturing.
Killing two birds with one stone: gender diversity, information disclosures and financial distress
Authors: Singh Kuldeep , Arora Akshita 
Published: September 2024

Purpose
The escalating instances of financial distress (FD) in corporate houses across the globe, call for immediate attention from policymakers, practitioners and academics equally. This study aims to examine how board gender diversity (GD) and information disclosures (ID) interact with each other to drive FD.

Design/methodology/approach
The authors apply dynamic panel data analysis on a sample of 255 Indian-listed firms from 2016 to 2023 to arrive at the econometric results.

Findings
The main findings indicate that while ID exacerbates distress, GD reduces it. In addition, GD also interacts with ID to curtail the adverse effects of disclosures on FD. Therefore, GD acts like a stone that kills two birds simultaneously, first by reducing the distress directly and second by limiting the negative effects of disclosures on distress.

Originality/value
This study extends the understanding of the implications of GD and complements existing research by investigating its direct and indirect impact on FD. It builds on the analysis to propose that GD can foster resilience against adverse FD situations. The findings should apply to other emerging nations after careful consideration of country-specific factors.
“Do you practice what you preach?” The effects of celebrities’ pro-environmental messages on social media on young adults’ pro-environmental behavior
Authors: Quesada Baena Luis , Binder Alice , Neureiter Ariadne , Saumer Melanie , Matthes Jörg 
Published: September 2024

Purpose
Celebrities communicating about environmental sustainability on social media have the power to inspire young adults to engage in pro-environmental behavior, such as reducing their consumption behavior or only buying local and organic food. However, at the same time, celebrities’ carbon-rich and luxurious lifestyles might generate skepticism when they preach about environmental action. Thus, this study aims to shed light on the effects of celebrity pro-environmental messages on young adults’ perceived authenticity and greenwashing and, subsequently, on young adults’ pro-environmental behavior. Moreover, this study examined the moderation effect of congruent (vs incongruent) messages in the celebrity’s social media profile depicting an environmentally friendly (vs unfriendly) lifestyle.

Design/methodology/approach
The authors conducted a 3 (celebrity pro-environmental messages: with concrete action claim vs without vs control group) x 2 (celebrity message-lifestyle congruence: congruent vs incongruent) between-subjects experimental study (N = 400) with young adults (16–26 years old).

Findings
Results showed a significant positive effect of celebrity pro-environmental messages with concrete green action claims on authenticity perceptions only when the social media profile depicted a congruent environmentally friendly lifestyle. Moreover, higher perceived authenticity of the celebrity by social media audiences led to a higher likelihood of young adults’ engagement in pro-environmental behavior.

Originality/value
To the best of the authors’ knowledge, this study is the first to consider celebrity message characteristics and young adults’ perceptions of authenticity and greenwashing when investigating the effects of celebrity pro-environmental messages on young adults’ pro-environmental behavior.
Perspectives of Japanese patients on psoriatic disease burden: Results from “Psoriasis and Beyond,” the Global Psoriatic Disease Survey
Authors: Okuse Masanori , Soekawa Masayuki , Itakura Asako , Kawamura Taisuke , Mburu Sicily , Frade Susan , Okubo Yukari 
Published: September 2024

AbstractPsoriatic disease (PsD) is a chronic disease affecting skin (psoriasis) and joints (psoriatic arthritis, PsA) that has a significant impact on patients' quality of life (QOL). We report findings from the Japanese subgroup of patients included in Psoriasis and Beyond: The Global Psoriatic Disease Survey, a cross‐sectional, quantitative online survey of patients with self‐reported, healthcare professional (HCP)‐diagnosed, moderate‐to‐severe plaque psoriasis, with or without PsA. Eligible patients who were recruited online completed a 25‐min internet‐based survey in Japanese. We assessed patients' understanding of the systemic nature of PsD, disease burden, perception towards their HCPs, treatment expectations, and satisfaction with care. Of the 148 patients, 74% were females. In total, 65% of patients were aware of the systemic nature of their disease. A minority of patients (27%) were aware that PsA was related to their psoriasis, and 30% and 42% of patients were unaware of any manifestations and comorbidities, respectively, related to PsD. Overall, 21% of patients reported that their disease has a “very large” to “extremely large” impact on their QOL (assessed by Dermatology Life Quality Index score), while the majority (61%) reported a “small” effect or “no effect” at all on QOL. Patients experienced stigma and discrimination and had a negative impact on relationships due to PsD. More patients with psoriasis and concomitant PsA (66%) were satisfied with their current treatment than those with psoriasis alone (46%). Overall, 41% of patients were not involved in deciding their treatment goals. These results suggest that Japanese patients may not be fully aware of the systemic nature of PsD, its manifestations and comorbidities. While these patients were somewhat satisfied with their current treatment, they were only occasionally consulted in deciding treatment goals. Policy measures are required to address the stigma and discrimination experienced by patients. Increased patient participation in their care supports shared decision‐making and enhanced treatment outcomes.
The Work of Whiteness1
Authors: Morgan Helen 
Published: September 2024

AbstractThe division of the races, created for the economic and political purposes of justifying slavery and colonialism, is a deep, entrenched, social structure which creates and promotes white privilege and is one within which we all live. No one can be free from it. This presentation is rooted in the assumption that the problem of racism today is a problem of whiteness and that it is an examination of this construct, therefore, which needs to be central to seeking a solution to this destructive dynamic. The work required of whiteness and the letting go of privilege is essential if we are to dismantle the system of racism that is so embedded within our society. I argue this is no altruistic endeavour but that, whilst clearly doing untold harm to people of colour, such a system also limits and distorts the development and individuation of white individuals and the society in which we are citizens.
Factors affecting UK anaesthetic trainees' wellbeing and stress: a scoping review
Authors: Winter Sophie , Brennan Nicola , Gale Thomas 
Published: September 2024

SummaryBackgroundPoor wellbeing and stress in UK anaesthetic trainees impacts significantly on clinical performance, workforce retention and patient care. This study aimed to provide an overview of the evidence in this field and to explore the factors affecting wellbeing and stress in UK anaesthetic trainees.MethodsMEDLINE, Embase, PsycINFO, and ERIC were searched, in addition to organisational websites. Literature reporting factors affecting wellbeing and stress in UK anaesthetic trainees from 2009 to present were included.ResultsFollowing exclusions, 45 studies were identified. Only five papers included qualitative analyses. Within these studies, 28 different phenomena related to wellbeing and stress were investigated. Thirty‐one different factors affecting anaesthetic trainees' wellbeing and stress were identified in this review. These have been summarised as individual; training; clinical role; progression; work patterns; resources; rest; support; and cultural factors. External factors were described as affecting wellbeing and stress more frequently than internal factors. The most frequently cited individual factors were fatigue and pre‐existing health status.ConclusionsThe wide scope of phenomena of interest and measurement tools emphasises the challenge of defining and researching the concept of wellbeing. Despite these limitations, we have created a novel conceptual model of individual and external factors affecting UK anaesthetic trainees' wellbeing and stress. This supports an increased awareness and understanding of these factors, so that improvements can be made to practice and policy.
Aloperine protects the testis against testicular ischemia/reperfusion injury in rats
Authors: Wei Shichao , Xiao Junshen , Ju Feng , Hu Zhaoyang 
Published: September 2024

AbstractBackgroundTesticular torsion/detorsion can cause testis loss and infertility. Aloperine is a major active alkaloid extracted from Sophora alopecuroides Linn. It has been shown to have organ‐protective effects. However, the effects of aloperine on the testis and its underlying mechanisms remain unclear.ObjectivesThis study investigated the effect of aloperine on testicular torsion/detorsion injury in rats.Materials and MethodsMale Sprague‐Dawley rats were randomized to the sham‐operated (sham), testicular I/R (TI/R), or aloperine preconditioning (ALOPre) or postconditioning (ALOPost) groups. All rats except for the sham‐operated rats were subjected to 3 h of right spermatic cord torsion (720°, clockwise), followed by 3 h of detorsion. Aloperine (10 mg/kg) was intravenously administered before testicular torsion (ALOPre) or at the onset of testicular detorsion (ALOPost). The therapeutic efficacy of aloperine was evaluated by histological analysis, oxidative stress evaluation, inflammatory response examination, apoptosis analysis, protein analysis, and immunohistological assessment.ResultsCompared with TI/R, aloperine protected both the ipsilateral and contralateral testes against unilateral testicular I/R, as evidenced by a reduced testicular weight to body weight (TW/BW) ratio (ALOPre: p = 0.0037; ALOPost: p = 0.0021) and volume (ALOPre: p = 0.0020; ALOPost: p = 0.0009), less structural damage with better Johnsen (ALOPre: p = 0.0013; ALOPost: p = 0.0021), and Cosentino scores (ALOPre: p < 0.0001; ALOPost: p < 0.0001), increased mean seminiferous tubule diameter and mean seminiferous tubule epithelial height, decreased testicular apoptosis, and less oxidative stress and inflammatory response. In addition, aloperine significantly stimulated the phosphorylation of signal transducer and activator of transcription (STAT)‐3 in the ipsilateral testes following detorsion. Administration of Ag490 suppressed STAT‐3 phosphorylation, thereby abrogating the protective effects exerted by aloperine on the ipsilateral testis.Discussion and ConclusionAloperine has a strong testicular protective effect on the ipsilateral and contralateral testes after testicular torsion/detorsion. This aloperine‐induced ipsilateral testicular protection is mediated via the STAT‐3 signaling pathway.
Outcomes following extended resection of radiation‐induced angiosarcoma of the breast: a sarcoma unit experience and systematic review
Authors: Mor Eyal , Baker Benjamin , Henderson Michael A. , Lazarakis Smaro , Mitchell Catherine , Speakman David , Zinn Richard , Webb Angela , Snow Hayden , Gyorki David E 
Published: September 2024

AbstractPurposeRadiation‐induced angiosarcoma (RIAS) of the breast is a rare tumour with high rate of local recurrence. The aim of this study is to evaluate the outcome of radical resections.MethodsA retrospective analysis of all patients who underwent extended surgical resection for RIAS of the breast between 2013 and 2022. Included were patients who underwent radical resection, including complete resection of previously irradiated skin and underlying fascia of pectoralis major. Post‐operative and long‐term oncological outcomes were than analysed. A systematic review was performed using the MEDLINE database in the last 20 years.ResultsTwenty‐two (n = 22) patients met the inclusion criteria. The median length of the specimen was 220 mm (range, 120–377 mm). At a median follow‐up of 33.5 months (range, 7.9–102.4), 3 (13.6%) patients had both local and metastatic lung disease and 1 (4%) patient with only lung metastasis. The estimated 3‐ and 5‐year OS was 81.1% and 57.9%, respectively. The estimated 3‐ and 5‐year DSS was 91.7% and 65.5%, respectively. The estimated 3‐ and 5‐year DFS rate were both 75.2%. The systematic review identified 17 studies with a recurrence rate ranging from 33% to 100%.ConclusionsTreatment of RIAS of the breast with an up‐front locally extended approach is associated with a low rate of local recurrence compared with the reported literature.
Letter: Enhancing cirrhosis management—The critical role of social workers in supporting NAFLD surveillance
Authors: Ye Senlin , Liu Jinli , Zhou Ruyi 
Published: September 2024

LINKED CONTENTThis article is linked to Tran et al papers. To view these articles, visit https://doi.org/10.1111/apt.18024 and https://doi.org/10.1111/apt.18265
Glycaemic control is a modifiable risk factor for hepatocellular carcinoma and liver‐related mortality in patients with diabetes
Authors: Mao Xianhua , Cheung Ka‐Shing , Tan Jing‐Tong , Mak Lung‐Yi , Lee Chi‐Ho , Chiang Chi‐Leung , Cheng Ho‐Ming , Hui Rex Wan‐Hin , Leung Wai K. , Yuen Man‐Fung , Seto Wai‐Kay 
Published: September 2024

SummaryBackgroundOptimal glycaemic control has well‐established health benefits in patients with diabetes mellitus (DM). It is uncertain whether optimal glycaemic control can benefit liver‐related outcomes.AimsTo examine the association of optimal glycaemic control with hepatocellular carcinoma (HCC) and liver‐related mortality.MethodsIn a population‐based cohort, we identified patients with newly diagnosed DM between 2001 and 2016 in Hong Kong. Optimal glycaemic control was defined as mean haemoglobin A1c (HbA1c) <7% during the 3‐year lead‐in period after DM diagnosis. By applying propensity score matching to balance covariates, we analysed glycaemic control via competing risk models with outcomes of interest being HCC and liver‐related mortality.ResultsWe identified 146,430 patients (52.2% males, mean age 61.4 ± 11.8 years). During a median follow‐up duration of 7.0 years, 1099 (0.8%) and 978 (0.7%) patients developed HCC and liver‐related deaths. Optimal glycaemic control, when compared to suboptimal glycaemic control, was associated with reduced risk of HCC (subdistribution hazard ratio [SHR] 0.70, 95% CI 0.61–0.79). The risk of HCC increased with incremental HbA1c increases beyond >7% (SHR 1.29–1.71). Significant associations with HCC were also found irrespective of age (SHR 0.54–0.80), sex (SHR 0.68–0.69), BMI <25 or ≥25 kg/m2 (SHR 0.63–0.75), smoking (SHR 0.61–0.72), hepatic steatosis (SHR 0.67–0.68) and aspirin/statin/metformin use (SHR 0.67–0.75). A lower risk of liver‐related mortality in relation to optimal glycaemic control was also observed (SHR 0.70, 95% CI 0.61–0.80).ConclusionsGlycaemic control is an independent risk factor for HCC and liver‐related mortality, and should be incorporated into oncoprotective strategies in the general DM population.
Letter: Enhancing cirrhosis management—The critical role of social workers in supportingNAFLDsurveillance: Authors' reply
Authors: Tran Sally , Henry Linda , Nguyen Mindie H. 
Published: September 2024

LINKED CONTENTThis article is linked to Tran et al papers. To view these articles, visithttps://doi.org/10.1111/apt.18024andhttps://doi.org/10.1111/apt.18245.
Integrating chemokines and machine learning algorithms for diagnosis and bleeding assessment in primary immune thrombocytopenia: A prospective cohort study
Authors: Wen Qing , Sun Ting , Chen Jia , Li Yang , Liu Xiaofan , Li Huiyuan , Fu Rongfeng , Liu Wei , Xue Feng , Ju Mankai , Dong Huan , Dai Xinyue , Wang Wentian , Chi Ying , Yang Renchi , Chen Yunfei , Zhang Lei 
Published: September 2024

SummaryPrimary immune thrombocytopenia (ITP) is an autoimmune bleeding disorder, and chemokines have been shown to be dysregulated in autoimmune disorders. We conducted a prospective analysis to identify potential chemokines that could enhance the diagnostic accuracy and bleeding evaluation in ITP patients. In the discovery cohort, a Luminex‐based assay was employed to quantify concentrations of plasma multiple chemokines. These levels were subjected to comparative analysis using a cohort of 60 ITP patients and 17 patients with thrombocytopenia other than ITP (non‐ITP). Additionally, comparative evaluation was conducted between a subgroup of 12 ITP patients characterised by bleeding episodes (ITP‐B, as defined by an ITP‐2016 bleeding grade ≥2) and 33 ITP patients without bleeding episodes (ITP‐NB, as defined by an ITP‐2016 bleeding grade ≤1). Machine learning algorithms further identified CCL20, interleukin‐2, CCL26, CCL25, and CXCL1 as promising indicators for accurate diagnosis of ITP and CCL21, CXCL8, CXCL10, CCL8, CCL3, and CCL15 as biomarkers for assessing bleeding risk in ITP patients. The results were confirmed using enzyme‐linked immunosorbent assays in a validation cohort (43 ITP patients and 19 non‐ITP patients). Overall, the findings suggest that specific chemokines show promise as potential biomarkers for diagnosis and bleeding evaluation in ITP patients.
Understanding splenic B‐cell lymphoma/leukaemia with prominent nucleoli: Diagnosis, underpinnings for disease classification and future directions
Authors: Naresh Kikkeri N. 
Published: September 2024

SummaryThe 5th edition of the WHO classification of haematolymphoid tumours (WHO‐HAEM5) introduced a new category, splenic B‐cell lymphoma/leukaemia with prominent nucleoli (SBLPN). The diagnostic entity B‐cell prolymphocytic leukaemia (B‐PLL) has been discontinued and the category of hairy cell leukaemia variant (HCLv) has been conceptually reframed. B‐PLL and HCLv diagnoses were uncommon. Overlap existed between B‐PLL and other indolent lymphomas like chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL). HCLv lacked consistent cytomorphological, immunophenotypic and genetic features. To address these issues, the WHO‐HAEM5 classification has introduced SBLPN to serve as a temporary holding ground for entities that do not neatly fit into the existing classification. Cases previously classified as CD5‐negative B‐PLL and HCLv fall under the SBLPN category. Some splenic marginal zone lymphoma and splenic diffuse red pulp small B‐cell lymphoma cases with higher number of medium or large nucleolated B cells would also be classified as SBLPN under the WHO‐HAEM5. This review explores the rationale for discontinuing B‐PLL and HCLv diagnoses. It then examines the concept of SBLPN, offers practical guidance for diagnosis and discusses future directions in classifying splenic B‐cell lymphomas.
Green dreams are made of this: Futures consciousness and proenvironmental engagement
Authors: Lalot Fanny , Ahvenharju Sanna , Uusitalo Outi 
Published: September 2024

AbstractFutures consciousness (FC) refers to the capacity to understand, anticipate and prepare for the future. As a form of future orientation, it encompasses five interrelated dimensions of time perspective, agency beliefs, openness to alternatives, systems perception and concern for others. We present here cross‐sectional evidence that FC is related to greater environmental engagement, above and beyond other future orientation constructs. In two pre‐registered studies (one convenience student sample and one representative sample; N = 1041), we found that respondents with higher futures consciousness reported greater proenvironmental behaviour (consumption behaviour, land stewardship, social environmentalism and environmental citizenship). FC proved a better predictor of proenvironmental behaviour than the Zimbardo Inventory's Future Time Perspective and the Consideration for Future Consequences Scale (Study 1). FC was also related to stronger biospheric values (Study 2). However, it was not significantly related to personal environmental footprint (derived from a 16‐item calculator). Strikingly, the environmental footprint was also unrelated to the Proenvironmental Behaviour Scale, which could point to a lack of correspondence between measures of proenvironmental propensity and impact. We discuss implications for future‐thinking research and interventions aiming to improve futures consciousness.