bluuebunny/crossref_metadata_2025_split huggingface dataset:
Remote Health Consultations Supported by a Diabetes Management Web Application With a New Glucose Meter Demonstrates Improved Glycemic Control
Authors: Grady Mike , Cameron Hilary , Levy Brian L. , Katz Laurence B. 
Published: December 2015

Background: Cloud-connected diabetes applications enable health care professionals (HCPs) to monitor patient progress and offer the potential for remote consultations. OneTouch Reveal (OTR) is a cloud-based web application that aggregates data from blood glucose (BG) meters or insulin pumps and provides analytics to help patients and HCPs make more informed treatment and lifestyle decisions. This study assessed the experience of patients using OTR and the OneTouch Verio (OTV) BG meter and determined the extent of changes in glycemic control. Methods: Subjects with T1DM (23) or T2DM (17) uploaded BG meter results to OTR for 12 weeks. HCPs remotely reviewed progress using OTR and delivered telephone consultations at 4 and 8 weeks based on OTR insights. Results: After 12 weeks, mean HbA1c decreased by 0.4% ( P < .001) and 25% of subjects had a reduction of ≥1.0%. Reduction in HbA1c was similar in subjects with T1DM and T2DM, although subjects with T1DM started with higher baselines. In subjects with T2DM, mean BG decreased significantly from 175 to 161 mg/dl ( P < .001) with the percentage of above-range BG results decreasing from 33% to 24%. 80% of subjects confirmed OTR detected out-of-range glucose patterns and 84% of these subjects were able to correct the underlying pattern to get BG back in-range. Conclusions: OTR web application in combination with the OTV meter helped subjects with T1DM and T2DM effectively manage their diabetes and was associated with improved BG control over 12 weeks. Real-time visibility to subject data may help HCPs deliver focused and effective remote consultations.
Managing Educational Reforms during Times of Transition
Authors: Moccia Salvatore 
Published: December 2015

Being the leader of a university is a unique and diverse challenge ever since universities have been described by Cohen and Marchin (1974) as ‘organized anarchies’ with high inertia, unclear technologies and problematic goals. This could be in part due to the fact of the temporary status of their roles amplifying a sort of conflict of identity in that they seek to maintain an academic identity, whilst being under pressure to take a long–term strategy. Another challenging element in today’s world is the high competitive and changing environment that requires sometimes dramatic and long-term decisions in order to guarantee the survival of the academic institution. The current period presents a unique set of challenges and opportunities to universities and there is no doubt that the quality of leadership in the sector is crucial to developing the necessary entrepreneurialism and resilience required (Wooldridge, 2011). Drawing from the author’s own experience of working more than 20 years in developing leaders and adding the experience as professor of strategic management and manager in the higher education sector, the purpose of this article is to present a focused strategy summarized in six practical points that can help leaders of colleges and universities reinvent their industry and survive in the long term. Purpose: The purpose of this article is to analyze the challenges and opportunities to universities and thus to propose some practical solutions. Design/methodology/approach: The article is based on concepts and on the own experience of the author as manager in the higher education sector. Findings: A list of practical solution to modern challenges is proposed. Research limitations: The lack of empirical data that can validate the model. Practical Implications: Considering the emphasis placed on challenges and opportunities, the model can have some practical implications in the management of universities. Originality/value: The article attempts to present a complete list of challenges and opportunities universities are facing. The list can provide a basis for further analysis from universities’ managers.
Comparative morphology of the postpharyngeal gland in the Philanthinae (Hymenoptera, Crabronidae) and the evolution of an antimicrobial brood protection mechanism
Authors: Weiss Katharina , Strohm Erhard , Kaltenpoth Martin , Herzner Gudrun 
Published: December 2015

AbstractBackgroundHymenoptera that mass-provision their offspring have evolved elaborate antimicrobial strategies to ward off fungal infestation of the highly nutritive larval food. Females of the Afro-EuropeanPhilanthus triangulumand the South AmericanTrachypus elongatus(Crabronidae, Philanthinae) embalm their prey, paralyzed bees, with a secretion from a complex postpharyngeal gland (PPG). This coating consists of mainly unsaturated hydrocarbons and reduces water accumulation on the prey’s surface, thus rendering it unfavorable for fungal growth. Here we (1) investigated whether a North AmericanPhilanthusspecies also employs prey embalming and (2) assessed the occurrence and morphology of a PPG among females of the subfamily Philanthinae in order to elucidate the evolution of prey embalming as an antimicrobial strategy.ResultsWe provide clear evidence that females of the North AmericanPhilanthus gibbosuspossess large PPGs and embalm their prey. The comparative analyses of 26 species from six genera of the Philanthinae, using histological methods and 3D-reconstructions, revealed pronounced differences in gland morphology within the subfamily. A formal statistical analysis based on defined characters of the glands confirmed that while all members of the derived tribe Philanthini have large and complex PPGs, species of the two more basal tribes, Cercerini and Aphilanthopsini, possess simple and comparatively small glands. According to an ancestral state reconstruction, the complex PPG most likely evolved in the last common ancestor of the Philanthini, thus representing an autapomorphy of this tribe.ConclusionPrey embalming, as described forP. triangulumandT. elongatus, and now also forP. gibbosus, most probably requires a complex PPG. Hence, the morphology and size of the PPG may allow for inferences about the origin and distribution of the prey embalming behavior within the Philanthinae. Based on our results, we suggest that prey embalming has evolved as an antimicrobial strategy in and is restricted to the tribe Philanthini, which seems to face exceptional threats with regard to fungal infestations of their larval provisions.
Noise Measurement in a Mechanized Opencast Bauxite Mine: A Case Study
Authors: Tripathy D.P. , Rao D.S. 
Published: December 2015

Occupational noise is one of the most common pollutants in the mining sector. Prolonged exposure of miners to high levels of noise can cause noise induced hearing loss besides several non-auditory health effects. As these effects have a significant impact on people's health, it is essential to assess the noise exposure and to adopt ameliorative solutions. This work has been carried out to study the noise levels of different machines in a highly mechanized opencast bauxite mine of Odisha, India. A number of measurements have been carried out using an Extech 1/3 Octave band analyser and sound level meter to collect data where the miners are exposed to different tasks during the occupational process. Noise measurements were carried out at work places of 10 different machinery sources in the bauxite mine. The average noise levels generated from the different machines were compared with permissible exposure levels of workers as per OSHA guidelines. Further contour mapping was plotted to show the noise levels at each work place.
Pilot experience with opebacan/rBPI21 in myeloablative hematopoietic cell transplantation
Authors: Guinan Eva , Avigan David E , Soiffer Robert J , Bunin Nancy J , Brennan Lisa L , Bergelson Ilana , Brightman Spencer , Ozonoff Al , Scannon Patrick J , Levy Ofer 
Published: December 2015

Bacterial infection and inflammation contribute significantly to the morbidity and mortality of myeloablative allogeneic hematopoietic cell transplantation (HCT). Endotoxin, a component of the outer membrane of Gram-negative bacteria, is a potent inflammatory stimulus in humans. Bactericidal/permeability increasing protein (BPI), a constituent of human neutrophil granules, binds endotoxin thereby precluding endotoxin-induced inflammation and also has direct anti-infective properties against bacteria. As a consequence of myeloablative therapy used in preparation for hematopoietic cell infusion, patients experience gastrointestinal leak of bacteria and bacterial toxins into the systemic circulation and a period of inflammatory cytokine elevation associated with subsequent regimen-related toxicities. Patients frequently become endotoxemic and febrile as well as BPI-deficient due to sustained neutropenia. To examine whether enhancing endotoxin-neutralizing and anti-infective activity by exogenous administration of a recombinant N-terminal fragment of BPI (rBPI21, generic name opebacan) might ameliorate regimen-related toxicities including infection, we recruited patients scheduled to undergo myeloablative HCT to participate in a proof-of-concept prospective phase I/II trial. After the HCT preparative regimen was completed, opebacan was initiated 18-36 hours prior to administration of allogeneic hematopoietic stem cells (defined as Day 0) and continued for 72 hours. The trial was to have included escalation of rBPI21dose and duration but was stopped prematurely due to lack of further drug availability. Therefore, to better understand the clinical course of opebacan-treated patients (n=6), we compared their outcomes with a comparable cohort meeting the same eligibility criteria and enrolled in a non-interventional myeloablative HCT observational study (n = 35). Opebacan-treated participants had earlier platelet engraftment (p=0.005), mirroring beneficial effects of rBPI21previously observed in irradiated mice, fewer documented infections (p=0.03) and appeared less likely to experience significant regimen-related toxicities (p=0.05). This small pilot experience supports the potential utility of rBPI21in ameliorating HCT-related morbidity and merits further exploration.
Case Report: Postpartum hemorrhage associated with Dengue with warning signs in a term pregnancy and delivery
Authors: Phi Hung Le , Diem Nghi Tran , Hoang Anh Nguyen , Van Hieu Mai , Thien Luan Nguyen , Phuoc Long Nguyen , Trong Thach Than 
Published: December 2015

Background: Dengue infection during peripartum period, although rare in endemic regions, has challenged clinicians regarding its management, especially if a parturient woman experiences postpartum hemorrhage due to a classical risk factor of maternal bleeding.Case: A full-term pregnant Vietnamese woman was diagnosed with polyhydramnios and Dengue with warning signs (DWS). She was administered platelet transfusion prior to delivery and then gave birth to a healthy newborn. After active management of the third stage of labor, the patient suffered a postpartum hemorrhage which was caused by uterine atony and accompanied with thrombocytopenia. Therefore, we decided to administer uterotonic drugs and additionally transfuse platelets.Conclusion: We describe a case of postpartum hemorrhage caused by uterine atony and coinciding with Dengue infection during delivery period, which is a rare clinical entity. With timely detection and management, the patient was finally discharged without complications.
Supply Chain Contract Design Under Financial Constraints and Bankruptcy Costs
Authors: Kouvelis Panos , Zhao Wenhui 
Published: December 2015

We study contract design and coordination of a supply chain with one supplier and one retailer, both of which are capital constrained and in need of short-term financing for their operations. Competitively priced bank loans are available, and the failure of loan repayment leads to bankruptcy, where default costs may include variable (proportional to the firm’s sales) and fixed costs. Without default costs, it is known that simple contracts (e.g., revenue-sharing, buyback, and quantity discount) can coordinate and allocate profits arbitrarily in the chain. With only variable default costs, buyback contracts remain coordinating and equivalent to revenue-sharing contracts but are Pareto dominated by revenue-sharing contracts when fixed default costs are present. Thus, for general bankruptcy costs, contracts without buyback terms are of most interest. Quantity discount contracts fail to coordinate the supply chain, since a necessary condition for coordination is to proportionally reallocate debt obligations within the channel. With only variable default costs and with high fixed default costs exhibiting substantial economies-of-scale, revenue-sharing contracts with working capital coordination continue to coordinate the chain. Unexpectedly, for fixed default costs with small economies-of-scale effects, the two-firm system under a revenue-sharing contract with working capital coordination might have higher expected profit than the one-firm system. Our results provide support for the use of revenue-sharing contracts with working capital coordination for decentralized management of supply chains when there are bankruptcy risks and default costs. This paper was accepted by Serguei Netessine, operations management.
A phenomenological study of living with a partner affected with dementia
Authors: Meyer Jennie , Cullough Joanne Mc , Berggren Ingela 
Published: December 2015

Introduction: Caring for people affected by dementia is a collective effort that involves public health, primary care, and informal care. The third mainly comprises the efforts of spouses. Aim: This study aimed to describe spouses' experiences of living with a partner affected with dementia. Method: The study has a descriptive phenomenological approach based on a reflective life-world perspective. Seven in-depth interviews were conducted with spouses of persons affected with dementia. The interviews were audiotaped and analysed using the procedures described by Giorgi (2009) . Findings: The essence of living with a partner affected by dementia formed a comprehensive theme: from togetherness to loneliness, which along with three descriptive categories—changes in their partner's behaviour, changes in everyday life, and a changed future—describes the phenomenon. Conclusion: The theme ‘From togetherness to loneliness’ reflects the spouses' descriptions of their life-world. Daily life changed gradually in line with their partners' personality, and their role became that of a care provider rather than a spouse. Information and knowledge about dementia should be provided at an early stage. Health care has a major responsibility to meet their needs, thus ensuring that all parties are satisfied.
Prevalence of self-neglect in the caseloads of public health nurses
Authors: Day Mary Rose , Mulcahy Helen , Leahy-Warren Patricia 
Published: December 2015

Background: The extent of self-neglect on public health nurses' (PHNs) caseloads in Ireland is unknown. People who self-neglect may be vulnerable or hidden and, as a consequence, difficult to profile. PHNs in Ireland profile their areas to identify the nursing needs of their population. Aim: This paper aims to: collate caseloads on self-neglect on the basis of a review of community profile and health need assessments (CPHNA) and identify the geographical and demographic factors within which self-neglect cases were found. Method: A retrospective review of the CPHNA of student PHNs (n=88) was undertaken from 2010 to 2014 in a university in Ireland. In all, 88 community profiles were manually reviewed. Results: A total of 374 self-neglect cases were identified—79 cases were aged between 18–64 years and 295 were over 65 years. The range of self-neglect cases per profiled area was between 0 to 25. The geographic and demographic factors linked to self-neglect across profiles were higher rates of older people, deprivation, disadvantage, and cultural factors. Conclusion: This retrospective review illustrates that self-neglect is a prominent feature in PHN caseloads, which has not been identified previously. Early identification is important to promote the mental health and wellbeing of self-neglecting clients.
‘This is our city’: Realism and the sentimentality of place in David Simon’s The Wire
Authors: Valdez Jessica R. 
Published: December 2015

Abstract
Drawing upon theories of aesthetic realism, this article argues that The Wire develops a tension between the kind of representative typicality characteristic of realism and the exchangeability of labourers and goods in a capitalist system. By developing this tension, The Wire offers a nuanced critique of the ways in which capitalism renders individuals and geographical places as interchangeable placeholders, like pawns in a game of chess. The Wire’s use of realism retains the individualism of person and place, even as these figures represent something more than themselves in the fictional space of the show. I conclude by arguing that The Wire’s realism is mingled with an affective sentimentality associated with the idea of Baltimore.
Gaming for Affect: Museum Online Games and the Embrace of Empathy
Authors: Kidd Jenny 
Published: December 2015

Abstract
This article explores how museum online games encourage affective encounters in players. Video game theory has much to say about affect and empathy as ways into narrative worlds, and this literature is revisited to apply to museums’ games. Through two case studies – Ngā Mōrehu (The Survivors) (2010) from Te Papa Museum in Wellington, New Zealand, and Over the Top (2000) from the Canadian War Museum in Ottawa, Canada – appeals to empathy are scrutinized. Both games encourage players to adopt a first-person perspective within environments characterized by challenge and despair. These examples represent two approaches to game design and raise questions about the technical, educational and curatorial parameters of gaming for affect.
Into Darkness: Affect and Dark Space in Holocaust Exhibitions
Authors: Messham-Muir Kit 
Published: December 2015

Abstract
Since 1990, many Holocaust exhibitions have featured dark spaces. This article considers the development of these dark spaces and their display function at two institutions: the Holocaust Exhibition at the Imperial War Museum, London and the United States Holocaust Memorial Museum, Washington DC. By examining shifts in exhibition lighting, a correlation can be found between brighter displays addressing the broad sociopolitical context of Nazism and darker displays focusing more on individual experiences of the death camps. Drawing from phenomenology and museology, this article argues that museums utilize darkness to lead visitors to particular affective experiences and to provoke inquiry into the meanings of the Holocaust.
The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3
Authors: Roux Pierre-François , Frésard Laure , Boutin Morgane , Leroux Sophie , Klopp Christophe , Djari Anis , Esquerré Diane , Martin Pascal G P , Zerjal Tatiana , Gourichon David , Pitel Frédérique , Lagarrigue Sandrine 
Published: December 2015

Abstract
RNA editing is a posttranscriptional process leading to differences between genomic DNA and transcript sequences, potentially enhancing transcriptome diversity. With recent advances in high-throughput sequencing, many efforts have been made to describe mRNA editing at the transcriptome scale, especially in mammals, yielding contradictory conclusions regarding the extent of this phenomenon. We show, by detailed description of the 25 studies focusing so far on mRNA editing at the whole-transcriptome scale, that systematic sequencing artifacts are considered in most studies whereas biological replication is often neglected and multi-alignment not properly evaluated, which ultimately impairs the legitimacy of results. We recently developed a rigorous strategy to identify mRNA editing using mRNA and genomic DNA sequencing, taking into account sequencing and mapping artifacts, and biological replicates. We applied this method to screen for mRNA editing in liver and white adipose tissue from eight chickens and confirm the small extent of mRNA recoding in this species. Among the 25 unique edited sites identified, three events were previously described in mammals, attesting that this phenomenon is conserved throughout evolution. Deeper investigations on five sites revealed the impact of tissular context, genotype, age, feeding conditions, and sex on mRNA editing levels. More specifically, this analysis highlighted that the editing level at the site located on COG3 was strongly regulated by four of these factors. By comprehensively characterizing the mRNA editing landscape in chickens, our results highlight how this phenomenon is limited and suggest regulation of editing levels by various genetic and environmental factors.
Genetic Mapping of Resistance toMeloidogyne arenariainArachis stenosperma: A New Source of Nematode Resistance for Peanut
Authors: Leal-Bertioli Soraya C M , Moretzsohn Márcio C , Roberts Philip A , Ballén-Taborda Carolina , Borba Tereza C O , Valdisser Paula A , Vianello Rosana P , Araújo Ana Cláudia G , Guimarães Patricia M , Bertioli David J 
Published: December 2015

AbstractRoot-knot nematodes (RKN; Meloidogyne sp.) are a major threat to crops in tropical and subtropical regions worldwide. The use of resistant crop varieties is the preferred method of control because nematicides are expensive, and hazardous to humans and the environment. Peanut (Arachis hypogaea) is infected by four species of RKN, the most damaging being M. arenaria, and commercial cultivars rely on a single source of resistance. In this study, we genetically characterize RKN resistance of the wild Arachis species A. stenosperma using a population of 93 recombinant inbred lines developed from a cross between A. duranensis and A. stenosperma. Four quantitative trait loci (QTL) located on linkage groups 02, 04, and 09 strongly influenced nematode root galling and egg production. Drought-related, domestication and agronomically relevant traits were also evaluated, revealing several QTL. Using the newly available Arachis genome sequence, easy-to-use KASP (kompetitive allele specific PCR) markers linked to the newly identified RKN resistance loci were developed and validated in a tetraploid context. Therefore, we consider that A. stenosperma has high potential as a new source of RKN resistance in peanut breeding programs.