bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Duodenal SDH-Deficient Gastrointestinal Stromal Tumor in a Patient With a Germline SDHB Mutation
Authors: Elston Marianne S. , Sehgal Shekhar , Dray Michael , Phillips Elizabeth , Conaglen John V. , Clifton-Bligh Roderick J. , Gill Anthony J. 
Published: April 2017

Abstract

Context:
Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the gastrointestinal tract arising from the interstitial cells of Cajal. Succinate dehydrogenase (SDH)–deficient GISTs are a unique class of GIST defined by loss of immunohistochemical expression of SDHB, indicating dysfunction of the mitochondrial complex 2; lack of driver mutations in KIT and PDGFRA; and distinctive morphologic features and natural history. To date, all reported SDH-deficient GISTs have arisen in the stomach. We report an SDH-deficient GIST arising in the gastrointestinal tract outside the stomach.

Case description:
A 29-year-old man with a germline SDHB mutation (p.Arg90*) presented with acute upper gastrointestinal hemorrhage. Endoscopy identified a lesion in the second part of the duodenum, close to the distal common bile duct, consistent with a GIST. Endoscopic ultrasonography and magnetic resonance imaging did not demonstrate metastatic or nodal disease. Open transduodenal excision was performed to remove the tumor. Histologic evaluation confirmed the clinical diagnosis of a GIST, with positive staining for DOG1 and KIT. The mitotic count was low (1 per 50 high-power fields). Immunohistochemistry for SDHB was negative in the presence of an internal control. SDHA expression was retained. No somatic mutations were identified in KIT (exons 9, 11, 13, and 17) or PDGFRA (exons 12, 14, and 18). The germline SDHB mutation and loss of heterozygosity were confirmed on molecular testing of the tumor.

Conclusion:
We describe an SDH-deficient GIST occurring outside of the stomach. This case indicates that SDH-deficient GISTs may also arise in the small intestine.
Effects of Mixed Carotenoids on Adipokines and Abdominal Adiposity in Children: A Pilot Study
Authors: Canas J. Atilio , Lochrie Amanda , McGowan Amy Galena , Hossain Jobayer , Schettino Christopher , Balagopal P. Babu 
Published: April 2017

Abstract

Context:
Carotenoids have been implicated in the regulation of adipocyte metabolism.

Objective:
To compare the effects of mixed-carotenoid supplementation (MCS) versus placebo on adipokines and the accrual of abdominal adiposity in children with obesity.

Design and Setting:
Randomized (1:1), double-blind, placebo-controlled intervention trial to evaluate the effects of MCS over 6 months in a subspecialty clinic.

Participants:
Twenty (6 male and 14 female) children with simple obesity [body mass index (BMI) &gt; 90%], a mean age (± standard deviation) of 10.5 ± 0.4 years, and Tanner stage I to V were enrolled; 17 participants completed the trial.

Intervention:
MCS (which contains β-carotene, α-carotene, lutein, zeaxanthin, lycopene, astaxanthin, and γ-tocopherol) or placebo was administered daily.

Main Outcome Measures:
Primary outcomes were change in β-carotene, abdominal fat accrual (according to magnetic resonance imaging), and BMI z-score; secondary outcomes were adipokines and markers of insulin resistance.

Results:
Cross-sectional analysis of β-carotene showed inverse correlation with BMI z-score, waist-to-height ratio, visceral adipose tissue, and subcutaneous adipose tissue (SAT) at baseline. MCS increased β-carotene, total adiponectin, and high-molecular-weight adiponectin compared with placebo. MCS led to a greater reduction in BMI z-score, waist-to-height ratio, and SAT compared with placebo. The percentage change in β-carotene directly correlated with the percentage change in SAT.

Conclusions:
The decrease in BMI z-score, waist-to-height ratio, and SAT and the concomitant increase in the concentration of β-carotene and high-molecular-weight adiponectin by MCS suggest the putative beneficial role of MCS in children with obesity.
Hydrated Micellar Structure of Ethoxylated Nonyl Phenols from PGSE NMR
Authors: Bányai István , Lakatos István , Meier Gerhard , Nagy Zoltán , Vass Szabolcs 
Published: April 2017

Abstract
Solvent self-diffusion coefficients $D_{w}^{*}$ and Dw are respectively determined by PGSE NMR in the bulk solvent and in suitably prepared aqueous micellar solutions of a series of commercial ethoxylated nonyl phenols (ENPs) at 298 and 317 K. The capability of ENP micelles for obstructing the free diffusion of solvent molecules is characterized by the obstruction ratio $K = D_{w}/D_{w}^{*}$, which turns out to depend merely on the volume fraction of EO units present—regardless of significant changes in solute concentration, distribution of EO chain length, micellar aggregation number and temperature. The experiments are interpreted in terms of a renewed analytical model of ENP micellar structure, based on Tanford’s concept of hydrodynamic particle. The results from model fitting return the characteristic sizes of ENP monomers, support the ellipsoid shape of the micelles, indicate a stable EO shell, follow the trend in the variation of hydration number vs. the chain length predicted by thermal analysis in PEO solutions.
Foreigners vs. Natives: Bank Lending Technologies and Loan Pricing
Authors: Beck Thorsten , Ioannidou Vasso , Schäfer Larissa 
Published: April 2017

Can distance-related information asymmetries in credit markets be overcome with contract design and credit scoring models? To answer this question, we explore differences in foreign and domestic banks' credit contract terms and pricing models. Using a sample of firms that borrow from both domestic and foreign banks in the same month, we show that foreign banks are more likely to demand collateral and grant shorter maturity loans than domestic banks. Foreign banks also base their pricing on internal credit ratings and collateral pledges, while domestic banks price according to the length, depth, and breadth of their relationship with a firm. These findings confirm that foreign banks can overcome informational disadvantages using contract design and credit scoring models. However, we also show that there are limitations, with foreign banks facing higher default rates and lower returns on lending if not using collateral and short maturity as disciplining tools. This paper was accepted by Amit Seru, finance.
Are Immigrants Complements or Substitutes? Evidence from the Audit Industry
Authors: Aobdia Daniel , Srivastava Anup , Wang Erqiu 
Published: April 2017

Extensive debate exists among policy makers and economists about the employment of highly skilled immigrants in the United States. It remains unclear whether these immigrants perform complementary tasks in addition to their substitutive role relative to native graduates. Empirical studies examining these questions in a focused setting are scarce, principally because of the nonavailability of data. We examine these questions using the audit industry as a setting because of the availability of client, city, and office characteristic data at each audit office. This setting also allows us to answer whether immigration can address the growing human capital constraint in the audit industry. We find evidence of a complementary role of highly skilled immigrants. In addition, our results indicate a reputational spillover of client restatements at the audit office level to the labor markets. Our findings have immigration and education policy implications. This paper was accepted by Shivaram Rajgopal, accounting.
Assessment of Direct Oral Anticoagulant Prescribing and Monitoring Pre- and Post-Implementation of a Pharmacy Protocol at a Community Teaching Hospital
Authors: Miele Christina , Taylor Mary , Shah Aditi 
Published: April 2017

Background Direct oral anticoagulants (DOACs) have become popular alternatives to vitamin K antagonists for the treatment and prevention of thromboembolic diseases; however, there are limited data regarding the appropriate use of DOACs in clinical practice. To ensure safety and efficacy of these medications, it is important that decisions regarding their use in patients rely on the available evidence. Objective The purpose of this study was to evaluate the appropriateness of DOAC prescribing in adult patients before and after the implementation of a pharmacist-driven DOAC protocol. Methods Data were collected on adult patients admitted to a community teaching hospital who received DOAC therapy for at least 2 days between January and March 2015 (pre-intervention group) and between January and March 2016 (post-intervention group). These data were analyzed to measure inappropriately prescribed DOACs, defined based on DOAC indication, renal function, drug interactions, and other pertinent patient-specific factors. Prior to the start of data collection for the post-intervention group, a pharmacist-driven protocol was developed and implemented. DOAC education was provided to pharmacists, including an evidence-based prescribing table to guide appropriate DOAC therapy. Comparisons were made between the pre-intervention and post-intervention groups to determine the impact of the pharmacist-driven service on appropriate DOAC prescribing. Results Fifty patients were analyzed in the pre-intervention group compared with 85 patients in the post-intervention group, with a total of 333 and 816 doses administered, respectively. Of the total doses administered, 32.4% were considered inappropriate in the pre-intervention group compared with 13.8% in the post-intervention group (adjusted odds ratio [OR], 0.42, 95% CI, 0.19-0.96; p = 0.039). Conclusions Implementing a pharmacist-driven DOAC service significantly improved appropriate prescribing of these agents. Provider education regarding DOAC use is essential to further increase appropriate prescribing of DOACs, optimize patients' therapy, and prevent adverse drug events.
Small chests and jointed boxes: Material texts and the play of resemblance in early modern print
Authors: Razzall Lucy 
Published: April 2017

Abstract
This article explores the material and metaphorical interactions between books and boxes in early modern English print culture. Building on ideas articulated by book historians Walter Ong, Jeffrey Todd Knight and Tessa Watt about the book as a material and metaphorical container, this article uses two case studies to explore some of the ways in which early modern print culture playfully engaged with the resemblances between book and box, as objects that both have the potential to contain and condense. Focusing on a version of scripture for children and a collection of Elizabethan epigrams, two printed texts that aspire to the neatness and the convenience that a box offers, the article considers how the book’s identity as a ‘container’ for ‘content’ was not merely functional but a symptom of the imaginative connections between the textual and material realms embodied in the book.
Ligatures of the early modern book
Authors: Scott-Warren Jason 
Published: April 2017

Abstract
This article proposes that the early modern book was constituted of numerous forms of stringing, tying and binding. Exploring ligatures at the level of the printed or handwritten letter-form, the stitching, the binding and the clasps or ties that served to open and close the book, I argue that books were not merely bound in to their containing volumes but were also bound outwards to material environments and social networks. The interlaced designs on decorative bookbindings are read as meditations on a connectedness that was actualized in shared ownership or giftgiving. Clasps turned the book into a box, and an apt metaphor for the human heart, while silk ties connected the book into the worlds of clothing and textiles. While our experience of connective communication is now dominated by the Internet, there are some signs that the material book is fighting back.
Boundaries to protocols: Conceptions of the ‘book’ in a networked environment
Authors: Drucker Johanna 
Published: April 2017

Abstract
The concept of the codex book is deeply imprinted on scholarly and literary traditions. It bears within it assumptions about bounded-ness and stability as defining features of the form. Works conceived in a networked environment are referred to as books, but may not exist within the same structural conditions. This article reviews some of the ways the conceptions of the physical codex are linked to production and poses questions about the identity of artefacts produced by processes and protocols in a networked environment. It argues that these unbounded and contingently configured documents do not merely extend the traditional codex, with its apparatus of footnotes, bibliographical citations, and other paratexts, but that these are substantively different types of textual productions because of their fluid instability.
Writing as Praxis: Catherine Ryan Interviews Nina Power
Authors: Power Nina , Ryan Catherine 
Published: April 2017

Abstract
A discussion between British philosopher, writer and activist, Nina Power, and Australian artist and writer, Catherine Ryan, about topics including: writing as a praxis; the political capacity of the polemical form; the politics of debate; the need to return to grand, structural terms for socio-political analysis; the role of the public intellectual; the effects of the Internet on the role of the public intellectual; and the relation between art and politics.
Democracy, Class, and White Settler Colonialism
Authors: Baker W. Oliver 
Published: April 2017

Abstract
This essay offers a critique of a set of responses to neoliberalism that emphasize liberal democracy and class solidary (worker identity) as the paramount sites today for productive collective struggle and creation of democratic life. Drawing on the insights of Indigenous critical theory and Afro-pessimist theory, I argue that theories of liberal democracy and worker-centered struggle fail to consider how the colonial antagonisms Indigeneity and Blackness continue not only to underpin neoliberal forms of exploitation and dispossession but to overdetermine how we conceptualize and organize our struggles for genuine forms of democratic life. To create genuine forms of democratic life we must conceptualize and build struggles not around points of convergence among differentially positioned groups in capitalism, but around the antagonisms that make democratic social belonging impossible in the first place. This requires that we confront the colonial antagonisms that remain with us today in the structures of settler colonialism and racial capitalism.
Manifesto for the New, Political Pop Song
Authors: Ryan Catherine 
Published: April 2017

Abstract
In order to address the political melancholia and negativity that beset the left, a new type of political pop song must be devised. This manifesto proposes a form of dance-pop that is conceived as a new sort of therapy, designed to combat the atomized, individualized way in which suffering is encountered under neoliberal capitalism. The description of political melancholy and neoliberal subjectivity is drawn from the work of Wendy Brown, Lauren Berlant, Nina Power and Alenka Zupančič. The new, political pop song will have five key characteristics: it will be tragic; it will be affirmative, rather than a song of protest; it will be anthemic and upbeat; it will be in a lyric mode but it will be about collective experiences; and it will spread online virally, via new media.
Digitalisierung industrieller Einfacharbeit
Authors: Hirsch-Kreinsen Hartmut 
Published: April 2017

Zusammenfassung
Gegenstand des vorliegenden Beitrags ist ein Beschäftigungssegment, das als „industrielle Einfacharbeit“ bezeichnet wird. Es wird gefragt, inwieweit einfache und gering qualifizierte Arbeit von dem zunehmenden Einsatz digitaler Technologien betroffen ist. Die im gegenwärtigen Digitalisierungsdiskurs oftmals formulierte These ist, dass einfache Tätigkeiten durch die neuen Technologien weitgehend substituiert werden. Demgegenüber wird im vorliegenden Beitrag gezeigt, dass keineswegs von einem eindeutigen Prozess der fortschreitenden Substitution von industrieller Einfacharbeit durch den Einsatz digitaler Technologien ausgegangen werden darf. Vielmehr lassen sich verschiedene Entwicklungspfade von Einfacharbeit erkennen, die jeweils sehr unterschiedliche Zukunftsperspektiven für diesen Arbeitstypus bezeichnen. Methodisch handelt es sich bei den Entwicklungspfaden industrieller Einfacharbeit um Szenarien, d.h. eine allgemeinverständliche Beschreibung möglicher Zukunftstrends. Damit werden die vorliegenden Befunde über die bisherige Entwicklung industrieller Einfacharbeit unter den Bedingungen einer fortschreitenden Nutzung digitaler Technologien in die Zukunft projiziert. Diese Szenarien bzw. Entwicklungspfade haben hypothetischen Charakter und sie bedürfen einer systematischen empirischen Validierung.
Unternehmen und die Cloud
Authors: Boes Andreas , Kämpf Tobias , Langes Barbara , Ziegler Alexander 
Published: April 2017

Zusammenfassung
Nicht mehr nur in den Unternehmen der IT-Industrie wird der digitale Umbruch immer stärker mit dem Thema Cloud verbunden. Wo aktuell über disruptive Innovationen von Geschäftsmodellen, Produktionsmodellen und der Organisation von Arbeit nachgedacht wird, scheinen Cloud-Konzepte eine wichtige Basis zu bilden. In diesem Beitrag wird danach gefragt, was sich hinter dieser Diskussion um Cloud verbirgt. Ausgehend von der Theorie der Informatisierung wird dazu ein genuin soziologisches Begriffsverständnis von Cloud entwickelt. Darauf aufbauend wird der Blick in die Praxis gerichtet. Im Rahmen von drei Fallstudien werden die Strategie eines Cloud-Anbieters der ersten Stunde aus dem Silicon Valley, die Transformation eines etablierten globalen Softwarekonzerns sowie die neue Geschäftsstrategie eines mittelständischen Industrieunternehmens untersucht. Im Zentrum stehen zwei Fragen: Welche Rolle spielen Cloud-Konzepte in den neuen Geschäftsstrategien der Unternehmen? Und welche Konsequenzen ergeben sich aus der Umsetzung der neuen Strategien für die Organisation von Arbeit in den Unternehmen?
Digitalisierung als eigensinnige soziale Praxis
Authors: Carstensen Tanja 
Published: April 2017

Zusammenfassung
Mit der Digitalisierung verändert sich gegenwärtig auch der Arbeitsalltag der Beschäftigten. Allerdings erfolgt die Aneignung der neuen Technologien nicht immer reibungslos. Auf der Grundlage von theoretischen Ansätzen der Science and Technology Studies, der Information System Research, der Praxistheorie, der Cultural Studies und der Soziologie des Digitalen fragt der Beitrag nach dem Eigensinn und der Handlungsmacht von Beschäftigten. Am Beispiel einer empirischen Studie über die Social-Media-Nutzung in Unternehmen wird gezeigt, wie Arbeitsorganisation, spezifische Haltungen der Subjekte sowie bestimmte Charakteristika der eingesetzten Technik deren Nutzung sowie die Emergenz neuer Praktiken verhindern.
Differential hemoglobin A sequestration between hemodialysis modalities
Authors: Naseeb Uzma , Zarina Shamshad , Jägerbrink Theres , Shafqat Jawed , Jörnvall Hans , Axelsson Jonas 
Published: April 2017

AbstractThis report evaluates plasma protein patterns, dialysates and protein analysis of used dialysis membranes from the same patient under hemodialysis in three separate modalities, using high-flux membranes in concentration-driven transport (HD), convection-driven hemofiltration (HF) and combined hemodialfiltration (HDF). The plasma protein changes induced by each of the three dialysis modalities showed small differences in proteins identified towards our previous plasma analyses of chronic kidney disease (CKD) patients. The used dialysate peptide concentrations likewise exhibited small differences among the modalities and varied in the same relative order as the plasma changes, with protein losses in the order HD>HDF>HF. The membrane protein deposits allowed quantification of the relative Hb removal ratios as ~1.7 for HD and ~1.2 for HDF vs. ~1.0 for HF. Hence, plasma protein alterations, dialysate peptide contents and membrane Hb deposits all identify HD as the modality with the most extensive filtration results and exemplifies the accessibility of protein analysis of used membrane filters for evaluation of dialysis efficiencies.
Capital Funded Models of Pension Insurance on Selected Examples Part 1
Authors: Sowiński Tomasz 
Published: April 2017

Abstract
This study on the capital funded models of pension insurance will present the economic concept [in theory] and the Chilean and Argentinian concepts of pension insurance implemented in those countries. On the one hand, extremely similar to each other, and on the other differing with so many detailed solutions that it might as well be said they are completely dissimilar. If we chronologically consider the Chilean system as the primary one, than the Argentinian system is its mirror image, however, reflected in the funhouse mirror.
Both solutions have aroused and continue to arouse many emotions. They have become the basis for formulating very general, almost axiological conclusions, as well as detailed legal, economic, sociological and other analyses. These are model examples of the so-called capital funded models in pension insurance, which were in their heyday not so long ago, and at present raise more and more skepticism.
However, they cannot be omitted when looking into the future functioning of the public pension systems, particularly due to the fact that they are constantly changing in pursuit of the target model, which will perhaps become the future universal model of the retirement security for the citizens of the globalized world.
Compact Quad-Band Bandpass Filter Using Double-Diplexing Structure
Authors: Xu Jin , Zhu Yan , Du Yong-Qian 
Published: April 2017

AbstractThis paper presents a compact quad-band bandpass filter (QB-BPF) using double-diplexing structure, which consists of two channel filters and a pair of modified manifold-coupled lines. Each channel filter is realized by the asymmetrical coupling shorted stub loaded stepped-impedance resonator (SSLSIR) dual-band bandpass filter (DB-BPF), and the modified manifold line constructed by lumped elements is proposed to connect two channel filters to constitute the QB-BPF. The fabricated QB-BPF occupies a compact circuit size of 0.178λ
The DLR Spaceborne SAR Calibration Center
Authors: Reimann Jens , Schwerdt Marco , Schmidt Kersten , Ramon Nuria Tous , Döring Björn 
Published: April 2017

AbstractA necessary activity for any SAR system is its calibration to establish the relation between radar measurements and geophysical parameters. During this process, all essential parameters of a SAR image are linked to their geophysical quantities. This includes the geolocation of the SAR image, its backscattering characteristics (in amplitude and in phase) and polarimetric information. The Microwaves and Radar Institute of the DLR has gained extensive experience in these calibration procedures during the last decades and has developed special methods and dedicated reference targets for spaceborne SAR system calibration. Through examples of calibration results obtained for different spaceborne SAR mission, the capabilities of the DLR SAR Calibration Center are presented.
The isomorphism problem for torsion free nilpotent groups of Hirsch length at most 5
Authors: Eick Bettina , Engel Ann-Kristin 
Published: April 2017

AbstractWe consider the isomorphism problem for the finitely generated torsion free nilpotent groups of Hirsch length at most five. We show how this problem translates to solving an explicitly given set of polynomial equations. Based on this, we introduce a canonical form for each isomorphism type of finitely generated torsion free nilpotent group of Hirsch length at most 5 and, using a variation of our methods, we give an explicit description of its automorphisms.