bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of a child with a prolactin secreting macroadenoma with temozolomide
Authors: Felker James , Patterson Brianna , Wrubel David , Janss Anna 
Published: November 2016

Abstract
Prolactinomas are a rare subset of brain tumors in pediatrics. We report a child with a prolactin secreting macroadenoma which was refractory to initial treatment with a dopamine antagonist. Given the location of her tumor she was ineligible for surgical resection. Temozolomide (200 mg/m
The effects of type 1 diabetes mellitus on cardiac functions in children: evaluation by conventional and tissue Doppler echocardiography
Authors: Ozdemir Osman , Koksoy Adem Yasin , Bulus Ayse Derya , Andiran Nesibe , Yagli Elif 
Published: November 2016

Abstract

Background:
Several studies have pointed out the existence of cardiac dysfunction in patients with type 1 diabetes mellitus (DM) even in the absence of ischemic, valvular, or hypertensive heart disease. The present study evaluated cardiac dysfunction and the relationship between severity of disease and degree of cardiac dysfunction in children with type 1 DM.

Methods:
In this prospective study, 31 patients with type 1 DM and 33 sex- and age-matched healthy children were evaluated with conventional echocardiography and tissue Doppler echocardiography (TDE). A correlation between cardiac functions and glycated hemoglobin (HbA

Results:
TDE results indicated that mitral valve early diastolic annular peak flow rate (E′), mitral valve systolic flow rate (S′), ratio of mitral valve early diastolic peak flow rate to mitral valve early diastolic annular peak flow rate (E/E′), and left ventricular (LV) myocardial performance index (MPI) were higher, and LV ejection time (ET) was shorter in patients with type 1 DM (p<0.05). In addition, tricuspid valve E′ and right ventricular (RV) MPI were higher, while RV ET and tricuspid E/E′ were lower in patients with type 1 DM compared to healthy children (p<0.05).

Conclusions:
Although conventional echocardiography revealed no difference between patients with type 1 DM and healthy children, TDE showed dysfunctions of both ventricles. This state is closely related to degree of blood glucose level control. These findings signify diagnostic value of TDE in the early detection of cardiac effects among patients with type 1 DM.
Crystal structure of (E)-2-({4-hydroxy-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]phenyl} methylidene)-1-indanone, C23H26N2O3
Authors: Tugrak Mehtap , Aydin Abdullah , Gul Halise Inci , Sahin Ertan , Akkurt Mehmet 
Published: November 2016

Abstract
C23H26N2O3, triclinic, P1̅ (No. 2), a = 10.6646(19) Å, b = 10.7784(17) Å, c = 11.150(2) Å, α = 67.787(7)°, β = 64.309(7)°, γ = 64.271(7)°, V = 1011.6(3) Å3, Z = 2, R
gt(F) = 0.0502, wR
ref(F
2) = 0.1481, T = 293 K.
The importance of staff to the efficiency of the tax agency
Authors: Höglund Mats 
Published: November 2016

Abstract
The Swedish Tax Agency is responsible for controlling as well as informing and assisting the taxpayers. Even if these tasks are not necessarily contradictory, they can be difficult to perform all at once. In their performance of duties, tax agency employees have to meet the expectations of the management as well as of the taxpayers. The goal fulfilment of the Tax Agency is contingent on the organisation’s ability to provide a stress-free working environment. Stress may cause physical and psychological problems.
Middle Dorset Communal Structures on Victoria Island
Authors: Friesen T. Max 
Published: November 2016

AbstractThis paper describes a cluster of large communal structures in the Oxford Bay region of
southeastern Victoria Island in Nunavut, Arctic Canada. The structures consist of linear stone outlines of
up to 24 meters in length, and resemble the relatively well-documented Late Dorset longhouses which have
been found across much of the Eastern Arctic. However, radiocarbon dates indicate that the Oxford Bay
structures were built and used from roughly 200 to 600-700 cal AD, placing them in the Middle Dorset
period. Elsewhere, Middle Dorset communal structures are rare, making the Oxford Bay phenomenon
unique. The sites are interpreted as resulting from population aggregations associated with the fall caribou
hunt, and may represent direct predecessors of the more widespread Late Dorset longhouses.
Phosphorus in Sintered Steels: Effect of Phosphorus Content and P Carrier in Sintered Steel Fe-C-P
Authors: Üregen B. , Gierl-Mayer C. , Danninger H. 
Published: November 2016

Abstract
Phosphorus as an alloy element is quite common in powder metallurgy, the contents industrially used being markedly higher than those present in wrought steels. In this study, the influence of phosphorus addition through different P carriers was investigated. PM steels of the type Fe-0.7%C-x%P (x = 0.0 … 0.8%) were manufactured by pressing and sintering in H2. It showed that Fe3P is the best phosphorus carrier, resulting in fine and regular microstructure and in high impact energy data at 0.3 … 0.45%P while red P and also Fe2P showed a tendency to agglomeration, with resulting secondary porosity. At high P levels the mechanical properties tend to drop, for the tensile strength at P > 0.60%P while for the impact energy the threshold is 0.45%P. The dimensional behaviour of Fe-C-P can be related to PM aluminium alloys, expansion by transient liquid phase being followed by shrinkage by persistent liquid phase, at least at higher temperatures. In contrast to the dimensional behaviour, degassing and reduction is hardly affected by the phosphorus content.
Neutron capture cross section measurements and theoretical calculation for the186W(n,γ)187W reaction
Authors: Al-abyad Mogahed , Mohamed Gehan Y. 
Published: November 2016

AbstractNeutron capture cross section (σ0) and resonance integral (I0) of the reaction186W(n,γ)187W were measured experimentally using the research reactor (ETRR-2) and an Am–Be neutron source, also calculated using TALYS-1.6 code. The present results ofσ0are (39.08±2.6, 38.75±0.98 and 38.33 barn) andI0are (418.5±74, 439.3±36 and 445.5 barn) by using the reactor, neutron source and TALYS-1.6, respectively. The present results are in acceptable agreement with most of the previous experimental and evaluated data as well as the theoretical calculations.
Large Custom Mount for a Drawing on Tracing Paper
Authors: Smith Theresa J. , Brückle Irene , Meyer Fabienne 
Published: November 2016

Abstract
As a mount support for a large drawing on tracing paper, six honeycomb panels were adhered with Primal AC 33 acrylic adhesive to a wooden latticed strainer. The 13 mm-thick honeycomb panels were lap joined and the overlapping edges tacked down with Beva® 371 heat seal film (0.025 mm thickness) to conceal the joins. Japanese paper hinges were adhered at strategic and unobtrusive locations along the top and right verso edges of the drawing and threaded through the honeycomb panel for attachment on its verso. After the top hinges had been secured to the mount, the drawing was allowed to settle in a vertical position and then the remaining hinges were secured to the mount. The spaces between the lattice bars on the verso were filled with honeycomb panel pieces for added mechanical protection and moisture migration control. Mount and drawing are in good condition after 10 years.
Primary histiocytic sarcoma of the uterine cervix: an extremely rare entity
Authors: Binesh Fariba , Karimi-Zarchi Mojgan , Vahidfar Mohammad Reza , Hadgiabadi Zahra Kargar 
Published: November 2016

Abstract

Objective. Histiocytic sarcoma (HS) is an extraordinary rare tumor and it has an offensive clinical course. HS of the uterine cervix is a far uncommon tumor with just a few cases described so far. Here we presented a case of primary HS of the uterine cervix in a 62-year-old female initially misdiagnosed as large cell non-keratinizing squamous cell carcinoma. To the best of our knowledge, this is the first reported case of HS of the uterine cervix from Iran.

Case report. The patient presented with post-menopausal vaginal bleeding. Further evaluations revealed the presence of a relatively large cervical mass that was sampled. Under the preliminary diagnosis of large cell non-keratinizing squamous cell carcinoma, the patient underwent radical surgery. Postoperative pathological examination confirmed the diagnosis of HS of the uterine cervix. The patient received chemotherapy.

Conclusion. Clinical presentations of HS of the uterine cervix are very similar to more common cervical tumors; as a result its diagnosis relies on immunohistochemical methods. A correct diagnose could lead to the proper and timely treatment.
The effect of an educational intervention in family phisicians on self-rated quality of life in patients with medically unexplained symptoms
Authors: Ivetić Vojislav , Pašić Klemen , Selič Polona 
Published: November 2016

Abstract

Introduction
Medically unexplained symptoms (MUS) are very common in family medicine, despite being a poorly-defined clinical entity. This study aimed to evaluate the effect of an educational intervention (EI) on self-rated quality of life, treatment satisfaction, and the family physician-patient relationship in patients with MUS.

Methods
In a multi-centre longitudinal intervention study, which was performed between 2012 and 2014, patients were asked to rate their quality of life, assess their depression, anxiety, stress and somatisation, complete the Hypochondriasis Index, the Medical Interview Satisfaction Scale and the Patient Enablement Instrument for assessing the physician-patient relationship, before and after the EI.

Results
The mean values before and after the intervention showed that after the EI, patients with MUS gave a lower (total) mean rating of their health issues and a higher rating of their quality of life, and they also had a more positive opinion of their relationship with the physician (p<0.05). However, there were no differences in the (total) rating of treatment satisfaction before and after the EI (p=0.423). Significant differences in the symptoms in patients with MUS before and after the intervention were confirmed for stress, somatisation and hypochondriasis (p<0.05).

Conclusions
It could be beneficial to equip family physicians with the knowledge, skills and tools to reduce hypochondriasis and somatisation in MUS patients, which would improve patients’ self-rated health status.
Helminths of Wild Predatory Mammals (Mammalia, Carnivora) of Ukraine. Trematodes
Authors: Korol E. N. , Varodi E. I. , Kornyushin V. V. , Malega A. M. 
Published: November 2016

Abstract
The paper summarises information on 11 species of trematodes parasitic in 9 species of wild carnivorans of Ukraine. The largest number of trematode species (9) was found in the red fox (Vulpes vulpes). Alaria alata (Diplostomidae) appeared to be the most common trematode parasite in the studied group; it was found in 4 host species from 9 administrative regions and Crimea.
The Battles between Ramesses III and the “Sea-Peoples”
Authors: Ben-Dor Evian Shirly 
Published: November 2016

Summary:
While building on previous works by such scholars as Heinz and Spalinger, the article presents a new methodology specifically devised for the analysis of Egyptian war reliefs. The article contends that many historical reconstructions regarding the “Sea-Peoples” have ignored the basic principles of ancient Egyptian iconic art and preferred intuitive interpretations of the reliefs. This has led to historical misconceptions about the battles and aggressors. The new analysis provides a holistic reading of the reliefs within their context and is thereby able to present new insights as to the location of the battles and the nature of the “Sea-Peoples”.
A Stelophorous Statue in the Collection of National Museums Scotland
Authors: Scrivens Edward 
Published: November 2016

Summary:
A.1885.137 is a previously unpublished stelophorous statue in the collections of National Museums Scotland in Edinburgh. The following article provides a brief history and description of the object, translations of its inscriptions, discussions of its context within the wider object category (including the role of stelophorous statues in mediating solar and Osirian associations in New Kingdom tomb spaces, and the utility of material anthropology in developing a more dynamic understanding of these objects), and an evaluation of A.1885.137 and similar examples as members of a possible sub-group of stelophorous statues.
A Green Approach to the Synthesis of Reduced Graphene Oxide using Sodium Humate
Authors: Xiang Ning , Huang Jiguo , Zhao Honggang , Liu Chengjia , Liu Xingjuan 
Published: November 2016

Abstract
A green and simple chemistry approach was demonstrated to prepare reduced graphene oxide (rGO) using sodium humate (SH) as the reducing agent. Without using toxic and harmful chemicals, this method is environmentally friendly and suitable for the large-scale production of graphene. At first, the improved Hummers method to oxidize graphite for the synthesis of graphene oxide (GO) was applied, and then the as-prepared GO was reduced by SH to form rGO. Characterization was performed using Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscope (SEM), energy dispersive X-ray spectroscopy (EDX), X-ray photoelectron spectrometry (XPS) and Raman spectra. The intensity ratio of the D and G band (ID/IG) of GO after reduction with SH increases from 0.96 (GO) to 1.11 (rGO), the results obtained from the Raman spectra proved high purity of the final products.
Inactivation of the type I interferon pathway reveals long double‐stranded RNA‐mediated RNA interference in mammalian cells
Authors: Maillard Pierre V , Van der Veen Annemarthe G , Deddouche‐Grass Safia , Rogers Neil C , Merits Andres , Reis e Sousa Caetano 
Published: November 2016

AbstractRNA interference (RNAi) elicited by long double‐stranded (ds) or base‐paired viral RNA constitutes the major mechanism of antiviral defence in plants and invertebrates. In contrast, it is controversial whether it acts in chordates. Rather, in vertebrates, viral RNAs induce a distinct defence system known as the interferon (IFN) response. Here, we tested the possibility that the IFN response masks or inhibits antiviral RNAi in mammalian cells. Consistent with that notion, we find that sequence‐specific gene silencing can be triggered by long dsRNAs in differentiated mouse cells rendered deficient in components of the IFN pathway. This unveiled response is dependent on the canonical RNAi machinery and is lost upon treatment of IFN‐responsive cells with type I IFN. Notably, transfection with long dsRNA specifically vaccinates IFN‐deficient cells against infection with viruses bearing a homologous sequence. Thus, our data reveal that RNAi constitutes an ancient antiviral strategy conserved from plants to mammals that precedes but has not been superseded by vertebrate evolution of the IFN system.
Spatial Gene Frequency Waves Under Genotype-Dependent Dispersal
Authors: Novak Sebastian , Kollár Richard 
Published: November 2016

Abstract
Dispersal is a crucial factor in natural evolution, since it determines the habitat experienced by any population and defines the spatial scale of interactions between individuals. There is compelling evidence for systematic differences in dispersal characteristics within the same population, i.e., genotype-dependent dispersal. The consequences of genotype-dependent dispersal on other evolutionary phenomena, however, are poorly understood. In this article we investigate the effect of genotype-dependent dispersal on spatial gene frequency patterns, using a generalization of the classical diffusion model of selection and dispersal. Dispersal is characterized by the variance of dispersal (diffusion coefficient) and the mean displacement (directional advection term). We demonstrate that genotype-dependent dispersal may change the qualitative behavior of Fisher waves, which change from being “pulled” to being “pushed” wave fronts as the discrepancy in dispersal between genotypes increases. The speed of any wave is partitioned into components due to selection, genotype-dependent variance of dispersal, and genotype-dependent mean displacement. We apply our findings to wave fronts maintained by selection against heterozygotes. Furthermore, we identify a benefit of increased variance of dispersal, quantify its effect on the speed of the wave, and discuss the implications for the evolution of dispersal strategies.
Survey of Global Genetic Diversity Within theDrosophilaImmune System
Authors: Early Angela M , Arguello J Roman , Cardoso-Moreira Margarida , Gottipati Srikanth , Grenier Jennifer K , Clark Andrew G 
Published: November 2016

AbstractNumerous studies across a wide range of taxa have demonstrated that immune genes are routinely among the most rapidly evolving genes in the genome. This observation, however, does not address what proportion of immune genes undergo strong selection during adaptation to novel environments. Here, we determine the extent of very recent divergence in genes with immune function across five populations of Drosophila melanogaster and find that immune genes do not show an overall trend of recent rapid adaptation. Our population-based approach uses a set of carefully matched control genes to account for the effects of demography and local recombination rate, allowing us to identify whether specific immune functions are putative targets of strong selection. We find evidence that viral-defense genes are rapidly evolving in Drosophila at multiple timescales. Local adaptation to bacteria and fungi is less extreme and primarily occurs through changes in recognition and effector genes rather than large-scale changes to the regulation of the immune response. Surprisingly, genes in the Toll pathway, which show a high rate of adaptive substitution between the D. melanogaster and D. simulans lineages, show little population differentiation. Quantifying the flies for resistance to a generalist Gram-positive bacterial pathogen, we found that this genetic pattern of low population differentiation was recapitulated at the phenotypic level. In sum, our results highlight the complexity of immune evolution and suggest that Drosophila immune genes do not follow a uniform trajectory of strong directional selection as flies encounter new environments.
Stage-Specific Timing of the microRNA Regulation oflin-28by the Heterochronic Genelin-14inCaenorhabditis elegans
Authors: Tsialikas Jennifer , Romens Mitchell A , Abbott Allison , Moss Eric G 
Published: November 2016

AbstractIn normal development, the order and synchrony of diverse developmental events must be explicitly controlled. In the nematode Caenorhabditis elegans, the timing of larval events is regulated by hierarchy of proteins and microRNAs (miRNAs) known as the heterochronic pathway. These regulators are organized in feedforward and feedback interactions to form a robust mechanism for specifying the timing and execution of cell fates at successive stages. One member of this pathway is the RNA binding protein LIN-28, which promotes pluripotency and cell fate decisions in successive stages. Two genetic circuits control LIN-28 abundance: it is negatively regulated by the miRNA lin-4, and positively regulated by the transcription factor LIN-14 through a mechanism that was previously unknown. In this report, we used animals that lack lin-4 to elucidate LIN-14’s activity in this circuit. We demonstrate that three let-7 family miRNAs—miR-48, miR-84, and miR-241—inhibit lin-28 expression. Furthermore, we show genetically that these miRNAs act between lin-14 and lin-28, and that they comprise the pathway by which lin-14 positively regulates lin-28. We also show that the lin-4 family member mir-237, also regulates early cell fates. Finally, we show that the expression of these miRNAs is directly inhibited by lin-14 activity, making them the first known targets of lin-14 that act in the heterochronic pathway.
SCREENING OF THERMOSTABLE PROTEASE PRODUCING MICROORGANISMS ISOLATED FROM INDONESIAN HOTSPRING
Authors: Zilda Dewi Seswita , Harmayani Eni , Widada Jaka , Asmara Widya , Irianto Hari Eko , Patantis Gintung , Fawzya Yusro Nuri 
Published: November 2016

Although many proteases had been studied and characterized, only a few of them are commercially available. Protease thermostability is one of the crucial properties for industrialapplication. This research aimed to isolate and to screen the potential isolate which produce thermostable protease. There were 6 isolates (BII-1, BII-2, BII-3, BII-4, BII-6 and LII), isolated using solid Minimal Synthetic Medium (MSM) supplemented with 1.5% skim milk, that have, protease activity. Based on the 16S-rRNA gene sequencing analysis, isolates BII-1, BII-2 and BII- 6 were identified as Bacillus licheniformis, isolates BII-3 and BII-4 were identified as Bacillus subtilis, while isolate LII was identified as Brevibacillus thermoruber. Three isolates (BII-6, BII-4 and LII) were then further investigated for the second screening step using liquid MSM supplemented with 1% skim milk. The isolates (BII-6, BII-4 and LII) optimally produced protease when they were cultivated at 35, 30 and 50o C respectively after 22 h of incubation. Protease produced by BII-6, BII-4 and LII had optimum temperature of 65, 60 and 85o C, optimum pH at 7-8, 8 and 9 and stable up to 100 min at 55, 60 and 75o C respectively.
ANTIBIOTIKA, RESISTENSI, DAN RASIONALITAS TERAPI
Authors: Utami Eka Rahayu 
Published: November 2016

<p>Masalah resistensi bakteri terhadap antibiotika telah menjadi masalah internasional. Saat ini sedang digalakkan kampanye dan sosialisasi pengobatan secara rasional yang meliputi pengobatan tepat, dosis tepat, lama penggunaan yang tepat serta biaya yang tepat. Bakteri menjadi resisten untuk dapat bertahan hidup setelah melalui beberapa proses tertentu. Banyak hal yang bisa mendukung terjadinya resistensi.Pada akhirnya konsekuensi yang ditimbulkan sangat merugikan baik dari segi kesehatan, ekonomi maupun kesehatan masyarakat.Terapi rasional, regulasi pemerintah, juga edukasi masyarakat menjadi beberapa poin penting dalam stategi penanganan masalah resistensi ini.</p><p>Kata Kunci : antibiotika, resistensi, terapi, rasional.<br /><br /></p>