bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization and multiphysics analysis of high-performance lithium niobate modulators
Authors: Wang Huangfan , Chen Hao , Yang Shaohua , Dong Huafeng , Wu Fugen , Liao Wenyuan 
Published: October 2024

Thin-film lithium niobate electro-optic modulators (TFLN EOMs) are
widely utilized across various fields due to their exceptional
performance. In this theoretical study, we optimized a TFLN EOM
featuring a multimode interference coupler, cosine-curved waveguides,
and a modulating arm straight waveguide structure. By tuning the
etching depth, waveguide width, and geometric parameters of the
traveling wave electrodes, we achieved a half-wave voltage-length
product of 1.6V⋅cm and a 3 dB bandwidth of approximately
140 GHz. Additionally, we performed a multiphysics analysis to
investigate the temperature characteristics of the modulator. The
results indicate that increased temperature induces thermal-optic
effects in the material, leading to changes in the waveguide’s
refractive index and the optical beam phase, which results in
increased insertion loss. Moreover, the stress generated by thermal
expansion is concentrated in the modulator’s waveguide, representing a
weak point that is prone to failure.
Action observation intervention using three-dimensional movies improves the usability of hands with distal radius fractures in daily life-A nonrandomized controlled trial in women
Authors: Usuki Kengo , Ueda Hiroaki , Yamaguchi Toshiya , Suzuki Takako , Hamaguchi Toyohiro 
Published: October 2024

Objective
Prolonged immobilization of joints after distal radius fracture (DRF) causes cerebral disuse-dependent plasticity (DDP) and deterioration of upper extremity function. Action observation therapy (AOT) can improve DDP.

Trial design
This nonrandomized controlled trial (UMIN 000039973) tested the hypothesis that AOT improves hand-use difficulties during activities of daily living in patients with DRF.

Method
Right-handed women with volar locking plate fixation for DRF were divided into AOT and Non-AOT groups for a 12-week intervention. The primary outcome was difficulty in using the fractured hand, assessed with the Japanese version of the Patient-related Wrist Evaluation (PRWE). The secondary outcomes were range of motion (ROM) of the injured side and gap between measured ROM and patient-estimated ROM. The survey was administered immediately post operation and at postoperative weeks 4, 8, and 12. The AOT group used a head-mounted display and three-dimensional video during ROM exercises. The Non-AOT group used active ROM exercises alone. A generalized linear model (GLM) was used to confirm interactions and main effects by group and time period, and multiple comparisons were performed.

Results
Thirty-five patients were assigned to the AOT group (n = 18, median age, 74 years) or the Non-AOT group (n = 17, median age, 70 years). In the GLM, PRWE Total, PRWE Specific, and PRWE Usual scores revealed interactions between groups and periods. The post-hoc test revealed that the PRWE Specific scores (z = 3.43, p = 0.02) and PRWE Usual scores (z = 7.53, p<0.01) were significantly lower in the AOT group than in the Non-AOT group at 4 weeks postoperatively, whereas PRWE Total scores (z = 3.29, p = 0.04) were lower at 8 weeks postoperatively.

Conclusions
These results suggested that AOT can improve hand-use difficulties in right-handed women after DRF surgery. AOT positively affects the motor imagery of patients with DRF and can reverse the patient’s perceived difficulty in using the fractured hand during rehabilitation.
Aging-induced dysbiosis worsens sepsis severity but is attenuated by probiotics in D-galactose-administered mice with cecal ligation and puncture model
Authors: Pinitchun Chalisa , Panpetch Wimonrat , Bhunyakarnjanarat Thansita , Udompornpitak Kanyarat , Do Huy Thanh , Visitchanakun Peerapat , Wannigama Dhammika Leshan , Udomkarnjananun Suwasin , Sukprasansap Monruedee , Tencomnao Tewin , Tangtanatakul Pattarin , Leelahavanichkul Asada 
Published: October 2024

Introduction
Despite the well-established effects of aging on brain function and gut dysbiosis (an imbalance in gut microbiota), the influence of aging on sepsis-associated encephalopathy (SAE) and the role of probiotics in this context remain less understood.

Methods
C57BL/6J mice (8-week-old) were subcutaneously administered with 8 weeks of D-galactose (D-gal) or phosphate buffer solution (PBS) for aging and non-aging models, respectively, with or without 8 weeks of oral Lacticaseibacillus rhamnosus GG (LGG). Additionally, the impact of the condition media from LGG (LCM) was tested in macrophages (RAW 264.7 cells), microglia (BV-2 cells), and hippocampal cells (HT-22 cells).

Result
Fecal microbiome analysis demonstrated D-gal-induced dysbiosis (reduced Firmicutes and Desulfobacterota with increased Bacteroidota and Verrucomicrobiota), which LGG partially neutralized the dysbiosis. D-gal also worsens cecal ligation and puncture (CLP) sepsis severity when compared with PBS-CLP mice, as indicated by serum creatinine (Scr) and alanine transaminase (ALT), but not mortality, neurological characteristics (SHIRPA score), and serum cytokines (TNF-α and IL-6). Additionally, D-gal-induced aging was supported by fibrosis in the liver, kidney, and lung; however, CLP sepsis did not worsen fibrosis. Interestingly, LGG attenuated all parameters (mortality, Scr, ALT, SHIRPA, and cytokines) in non-aging sepsis (PBS-CLP) while improving all these parameters, except for mortality and serum IL-6, in aging sepsis (D-gal CLP). For the in vitro test using lipopolysaccharide (LPS) stimulation, LCM attenuated inflammation in some parameters on RAW264.7 cells but not BV-2 and HT-22 cells, implying a direct anti-inflammatory effect of LGG on macrophages, but not in cells from the brain.

Conclusion
D-gal induced fecal dysbiosis and worsened sepsis severity as determined by Scr and ALT, and LGG could alleviate most of the selected parameters of sepsis, including SAE. However, the impact of LGG on SAE was not a direct delivery of beneficial molecules from the gut to the brain but partly due to the attenuation of systemic inflammation through the modulation of macrophages.
The potential to prevent unnecessary emergency department visits by timely diagnosis of migraine–A prospective observational study
Authors: Drangova Hristina , Kofmel Nicole , Branca Mattia , Gloor David , Lehmann Beat , Exadaktylos Aristomenis , Jung Simon , Fischer Urs , Schankin Christoph J. 
Published: October 2024

Aim
Successful acute migraine treatment potentially prevents emergency room (ER) consultations but requires that the diagnosis of migraine was given earlier. The aim of this study is to quantify the problem of missed migraine diagnosis prior to ER visits.

Methods
Inclusion criterion for this single-center prospective study was the presentation at the ER for acute headache. Patients with acute migraine attacks were assessed for previous migraine attacks, and whether they were given a diagnosis of migraine in the past.

Results
Of 137 patients with migraine diagnosis at discharge, 108 (79%) had previous headache attacks fulfilling the criteria for migraine according to The International Classification of Headache Disorders 3rd edition (ICHD-3). Of those, 54 (50%) received the diagnosis for the first time.

Conclusion
Half of the migraine patients (50%) presenting in the ER for headache could have been diagnosed earlier. This highlights the need for better detection and treatment of migraine by pre-hospital healthcare providers, as earlier diagnosis and specific acute treatment could have prevented the ER visit.
Sintilimab plus chemotherapy with or without bevacizumab biosimilar IBI305 in EGFR-mutated non-squamous NSCLC patients who progressed on EGFR TKI therapy: A China-based cost-effectiveness analysis
Authors: Peng Juan , Xu Huiling , Liu Qiao 
Published: October 2024

Background
This study aims to compare the cost-effectiveness of sintilimab in combination with chemotherapy, with or without bevacizumab biosimilar IBI305, versus chemotherapy alone for patients with epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) who have progressed on tyrosine-kinase inhibitor (TKI) treatment from the perspective of the Chinese healthcare system.

Methods
10-year Markov model was developed using a 21-day cycle length. Transition probabilities were derived from the ORIENT-31 trial, while cost and health state utilities were obtained from publicly databases, local hospitals, and published literature. Incremental cost-effectiveness ratios (ICERs) were calculated as the primary model output and compared to a willingness-to-pay (WTP) threshold range of $15,289.34 to $38,223.34 per quality-adjusted life-years (QALY). Sensitivity analyses were performed to assess the robustness of the model.

Results
In the base-case analysis, sintilimab plus IBI305 and chemotherapy had an ICER of $53,266.32/QALYs, exceeding the upper WTP threshold. Sintilimab plus chemotherapy had an ICER of $15,329.11/QALY, slightly above the lower WTP threshold. Subgroup analysis yielded consistent results. Deterministic sensitivity analyses found no ICER for sintilimab plus chemotherapy beyond the upper WTP threshold. Most model input changes did not decrease the ICER of sintilimab plus IBI305 and chemotherapy below the upper WTP threshold. Probabilistic sensitivity analyses further demonstrated the cost-effectiveness superiority of sintilimab plus chemotherapy over sintilimab plus IBI305 and chemotherapy.

Conclusion
This study supports the cost-effectiveness of using sintilimab in combination with chemotherapy. Nevertheless, the cost-effectiveness of combining sintilimab with IBI305 and chemotherapy in this particular patient group may be lacking.
Treatment Preference Archetypes in Eosinophilic Esophagitis and Their Implications for Therapy
Authors: Chang Joy W. , Brophy Kelcie , Ryan Kerry A. , Rubenstein Joel H. , Dellon Evan S. , Wallner Lauren P. , Kim Hyungjin Myra , De Vries and Raymond 
Published: October 2024

INTRODUCTION:
Little is known about how patients make decisions about and prioritize therapies and disease management in eosinophilic esophagitis (EoE). We aimed to systematically identify and characterize patient perspectives and attitudes that influence decision making for EoE management.

METHODS:
To understand the diverse attitudes and values of patients with EoE, we designed a study using the Q-method. We iteratively developed 31 statements related to EoE disease management. Participants sorted statements by ranking from +4 (most agree) to −4 (most disagree). By-person factor analysis, using 2-factor and 3-factor rotation, revealed distinct preference archetypes.

RESULTS:
Thirty-four adults with EoE (mean age 40.9 years, 51.4% male, 82.9% White) were recruited from gastroenterology and allergy clinics from a single center. We identified 2 treatment-centered archetypes: Medication preference, driven by symptoms and the desire to minimize risk of complications and Natural treatment preference, focusing on identifying trigger foods and diet adherence. Three-factor analysis revealed an additional archetype: Treatment ambivalent, a view of EoE as a mild and episodic (not chronic) disease with low priority to treat. Comparison by factor revealed 54% of those in the natural preference archetype were recategorized as treatment ambivalent, suggesting that they see natural treatment as a less complicated or milder strategy and may be at risk of nonadherence and reduced treatment uptake.

DISCUSSION:
We identified 3 distinct treatment preference archetypes among individuals with EoE, underscoring the need for personalized treatment strategies, especially for those favoring natural approaches but masking ambivalence, and may be at risk of nonadherence or loss to follow-up.
Assessment of a new higher-order shear and normal deformation theory for the static response of functionally graded shallow shells
Authors: Shinde Bharti M. , Sayyad Atteshamuddin S. , Naik Nitin S. 
Published: October 2024

Abstract
Static response of simply supported functionally graded (FG) shallow shells using a new higher-order shear and normal deformation theory is focused in this article. The effects of transverse strains and stresses on the bending response of FG shell are considered by the present theory. The current theory considers the impacts of transverse normal and shear deformations that meet the requirements for traction-free boundary conditions. The virtual work principle is applied to the mathematical formulation of the present theory. The simply supported doubly curved shallow shell problems under the static transverse load are analyzed using Navier’s solution technique. To verify the existing theory, the current results are, whenever possible, compared with those that have already been published. Additionally, a few benchmark results are presented in this article that will be helpful to researchers in the future.
The unusual location of primary hydatid cyst: A case series study
Authors: Qaradaghy Seerwan Hama Shareef , Ismael Diyaree Nihad , Ameen Shorsh Hama Hussein , Mahmood Kawa Abdula , Aghaways Ismael Hama Amin , Shakor Fadhluddin Nasruddin , Abdullah Zana Othman , Ibrahim Kawa M. , Omer Mohammed Amin Ali , Mohammed Sangar Abdullah , Mohammed Aram Ahmed , Rasheed Safeen Hama 
Published: October 2024

Abstract

Background
Cystic echinococcosis mainly affects the liver and lungs, in which the larvae from the microvascular wall in the liver pass to the lungs and then to the blood circulation and settle in any tissue or organ.

Objectives
The objective of this study was to report the unusual location of hydatid cysts in infected patients in Sulaimaniyah City, Iraq.

Patients and methods
This retrospective case series study enrolled 13 patients. They underwent a surgical operation to excise their cyst after confirmed diagnosis with blood investigations, electrocardiogram, chest X-ray, computed tomography scan, and magnetic resonance imaging (when needed). After the operation, the cyst was confirmed with histopathological examination, and patients were advised to take an Albendazole tablet.

Results
Most patients were females from rural areas, with a mean age of 38.93 ± 14.4 years. Patients presented with cysts on the skin of the anterior abdominal wall, gluteal region, mesenteric area, pericardium, tibia bone meta diaphysis, right inguinal region, right thigh, skin of the anterior neck, spleen, left suprarenal gland, right breast, and the iliopsoas muscle.

Conclusions
The hydatid cyst can affect any body part with no site immune and often produces nonspecific symptoms.
Exploring Ethical Potentials of Christian Narrative Testimonies
Authors: Peetz Katharina 
Published: October 2024

Abstract
Over the last decades, the role of narratives in Christian theology and ethics has been debated controversially. In light of this, this article explores the ethical potential of Christian narrative testimonies. First, it shows that the mode of Christian testimony to God’s incarnation in Jesus Christ is narratively structured. Second, it unfolds a threefold hermeneutic of these narratives: a hermeneutic of the simultaneous presence and absence of God in these testimonies, a hermeneutic of commentary and criticism, and a hermeneutic of attentive humility in the face of other narratives. Last but not least, ethical potentials of Christian narrative testimonies come into view: These narratives can bear witness to God’s absent presence, especially when they reveal themselves as radical contingent, when they are open to transformation by narratives of the other and when they motivate people to question the status quo of any given society in order to act for a more just future.
A review of electrical and piezoelectric properties of nanocellulose biocomposites
Authors: Habib Abdul , Sapuan Salit Mohd , Zainudin Edi Syams , Atiqah Afdzaluddin 
Published: October 2024

Abstract
The increasing request for lightweight, environmentally sustainable materials with versatile functionality and strong mechanical properties is driving renewed interest in nanocellulose for electrical applications. Nanocellulose, a biologically derived polymeric nanomaterial, has seen significant growth in the global market due to advancements in nanotechnology and the increasing need for sustainable materials. This has accelerated research into the development of cellulose-based nanomaterials. However, nanocellulose on its own does not inherently possess the ability to function as a conductive material. To address this limitation, researchers have explored various modifications, such as combining nanocellulose with conductive materials or applying specific chemical treatments. These approaches have been shown to enhance the electrical conductivity of nanocellulose, making it suitable for use in electrically conductive composites. Over the past few decades, nanocellulose composites have been extensively studied for their applications in energy, electronics, biomedicine, health, and environmental sectors. Nanocellulose possesses a unique combination of exceptional properties, including biodegradability, renewability, and a distinctive fibrous structure, proving that it is the best choice for these uses. The superior electrical properties of nanocellulose-based composites, coupled with their flexibility, ease of production, and biocompatibility, make them highly desirable for various advanced technological applications. Significant advancements have been achieved by researchers in fabricating various types of nanocellulose materials and exploring their potential in nanogenerators, humidity sensors, gas sensors, and supercapacitors. The ability to modify the surface of nanocellulose and its robust properties offer numerous opportunities for creating hybrid materials within the electrical domain.
Efficacy of sustainable cementitious materials on concrete porosity for enhancing the durability of building materials
Authors: Huang HaoYang , Amin Muhammad Nasir , Khan Suleman Ayub , Khan Kaffayatullah , Qadir Muhammad Tahir 
Published: October 2024

Abstract
The degradation of concrete structures is significantly influenced by water penetration since water serves as the primary vehicle for the movement of harmful compounds. The process of capillary water absorption is widely recognized as a crucial indicator of durability for unsaturated concrete, as it allows dangerous substances to enter the composite material. The water absorption capacity of concrete is intricately linked to its pore structure, as concrete is inherently porous. The main goal of this work is to create an innovative predictive tool that assesses the porosity of concrete by analyzing its components using a machine-learning (ML) framework. Seven distinct batch design variables were included in the generated database: fly ash, superplasticizer, water-to-binder ratio, curing time, ground granulated blast furnace slag, binder, and coarse-to-fine aggregate ratio. Four distant ML algorithms, including AdaBoost, linear regression (LR), decision tree (DT), and support vector machine (SVM), are utilized to infer the generalization capabilities of ML algorithms to estimate concrete porosity accurately. The RReliefF algorithm was implemented to calculate the significant features influencing porosity. This study concludes that in comparison to the alternative techniques, the AdaBoost method demonstrated superior performance with an R
2 score of 0.914, followed by SVM (0.870), DT (0.838), and LR (0.763). The results of the evaluation of RReliefF indicated that the binder possesses a remarkable influence on the porosity of concrete.
Theoretical research on load distribution of composite pre-tightened teeth connections embedded with soft layers
Authors: Li Fei , Zhou Zhaopeng , Ye Shuting , Zhao Qilin , Chen Mingzhao , Gao Yifeng , Shi Lin 
Published: October 2024

Abstract
It has been proved by experiments that the soft layers can effectively adjust the load distribution ratio of composite pre-tightened tooth connection, but theoretical research on the composite pre-tightened tooth connection embedded with soft layers has not been carried out. Therefore, in this work, the load distribution theory of composite pre-tightened tooth connection embedded with soft layers is studied by spring stiffness method. First, based on deformation compatibility condition, the theoretical calculation formula of load distribution ratio of each tooth is derived by spring stiffness method. Then, load distribution ratio is obtained by experiments, and the theoretical calculation results are verified. Finally, through the derived formula, the load distribution ratio of the composite pre-tightened tooth connection embedded with soft layers is parameterized. Research shows that (1) The theoretical value is in good agreement with the experimental value, and the maximum error of calculation result of the load distribution of the joint is 8%; (2) Under the action of soft layers, each tooth of two-teeth and three-teeth joints are damaged at the same time, the ultimate bearing capacity is increased by 29.0 and 21.6%, respectively, compared with the traditional two-teeth and three-teeth joints; (3) The elastic modulus and thickness of soft layers have a significant impact on the load distribution ratio of each tooth.
Optimization of cholecystectomy timing during staged treatment of acute cholecystitis in elderly and senile patients with cholecystostomy
Authors: Vaganova P. S. , Melkonyan G. G. , Buriev I. M. , Kachurin S. A. , Pchelin V. V. 
Published: October 2024

Aim. To determine optimal timing for laparoscopic cholecystectomy in elderly and senile patients with cholecystostomy.Materials and methods. Treatment results of 37 patients aged 60 years and over at different terms after cholecystostomy formation were analyzed. The degree of senile asthenia, concomitant diseases, technical features of surgical aid, dynamics of the postoperative period, as well as morphological features of inflammatory changes in the gallbladder wall were assessed.Results. Pre-asthenia was detected in 12 (32%) patients, mild senile asthenia – in 14 (38%) patients, and moderate senile asthenia – in 11 (30%) patients. Polymorbidity was determined in all patients, with 23 patients having four or more diseases. In 3 (8%), 15 (40.5%), 15 (40.5%), and 4 (11%) cases, laparoscopic cholecystectomy was performed 3–9 days, 10–30 days, 2–6 months, and 6 months or more (1 conversion) after cholecystostomy.Conclusion. In elderly and senile patients, laparoscopic cholecystectomy performed 10–30 days after cholecystostomy is optimal, safe, and affordable. Radical intervention in this period is not associated with technical difficulties. Reduced terms of external drainage of the gallbladder contribute to improving the elderly patient’s quality of life and their social adaptation, while shortening the period of postoperative recovery. When planning surgical interventions in a patient over 60 years old, account should be taken of comorbidities, polypragmasy, and senile asthenia.