bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trigeminal neuralgia and risk of cancer: A population-based cohort study
Authors: Risager Lykke Malene , Elser Holly C. , Fuglsang Cecilia Hvitfeldt , Farkas Dóra Körmendiné , Sørensen Henrik Toft 
Published: October 2024

Background Evidence of an association between trigeminal neuralgia (TN) and subsequent cancer risk remains sparse. The present study aimed to examine the association between TN and cancer risk in the Danish population. Methods A nationwide population-based cohort study using hospital diagnoses collected routinely and prospectively from Danish population-based registries in 1994–2022. Results We identified 7846 individuals with a first-time diagnosis of TN. Within one year of diagnosis, we observed 193 cancer cases (standardized incidence rate (SIR) = 2.45, 95% confidence interval (CI) = 2.11–2.82). Absolute risk (AR) for all cancers within one year of TN diagnosis was 2.5% (95% CI = 2.2–2.9). Cancers of the head, neck and nervous system were most strongly associated with TN (AR 0.9% (95% CI = 0.7–1.1); SIR = 13.5 (95% CI = 10.5–17.0)) and the risk was persistently elevated one year after TN diagnosis. We observed 827 cancer diagnoses beyond one year after TN diagnosis, where smoking related cancers were associated with elevated cancer risk (SIR 1.13 = (95% CI = 0.98–1.29)). Conclusions TN was associated with an elevated risk of cancers of the head, neck and nervous system including site-specific cancers in the area. Our results suggest the potential importance of smoking related tumors in TN, either as a symptom, cause or shared risk factor.
Axiological reflection for nursing ethics education: The missing link in understanding value conflicts
Authors: Groothuizen Johanna Elise 
Published: October 2024

Texts from various areas of the world highlight the importance of moral values like compassion and integrity in healthcare. Such values are held in high esteem by healthcare organisations and are actively ‘taught’ within nursing ethics education to ensure their presence within the future workforce. With such an emphasis, it is easy to overlook that moral values are not the only values that people, including nurses, hold. Other personal values – which may or may not conflict with moral values – are simultaneously present within individuals. Therefore, moral behaviour cannot be predicted solely by the presence/absence of certain moral values. Instead, it depends on how these integrate into an individual’s broader values system. Using Schwartz’s axiological Theory of Basic Human Values as a framework, I argue that moral values are but one part of an individual’s greater personal values spectrum, which also includes, for instance, hedonism, achievement, and power. Within this spectrum, values are ordered hierarchically, influencing behaviour based on relative priority. When a conflict arises between moral and other personal values, the prioritisation of moral values is a requirement for moral behaviour. I discuss how socialisation in suboptimal clinical practice environments can cause moral values to be deprioritised and argue that the development of practical reasoning skills is paramount to learning to balance one’s values and guide decision-making. I advocate for the integration of (meta-)axiological reflection – characterised by introspection and aimed at developing a deeper understanding of one’s personal values spectrum – within nursing ethics education. This involves exploring the origin, meaning, and perceived relative importance of one’s different personal values. By incorporating specific reflective exercises, students can increase self-awareness/insight and enhance their ability to recognise situations where conflicts between their moral values and other personal values may occur, which is likely to benefit moral decision-making in clinical practice.
Comparison of Cradle Breastfeeding Position with Cross-Cradle Breastfeeding Position in Term Newborn on Their Weight Pattern—Randomized Controlled Trial
Authors: Patel Shaily , Gaur Ajay 
Published: October 2024

Introduction Breastfeeding is not a choice it is a shared responsibility of the mother. Breastfeeding is a right of every baby. Common breastfeeding positions are side-lying, cradle hold, cross-cradle hold, football, laid-back. There is a little data available to compare different breastfeeding positions in terms of maternal comfort. This study was conducted with the objective to see the effect of breastfeeding positions on weight pattern and urine frequency along with maternal comfort and Latching on, Audible swallowing, Type of nipples, Comfort, and Help (LATCH) score. Objectives The aim of this study was to compare effect of two breastfeeding techniques (cradle and cross-cradle) of mother delivered by normal vaginal delivery on weight pattern of term newborn and to compare maternal comfort, LATCH score, and urinary frequency between the two groups. Methods This randomized controlled trial is performed in 200 mother newborn dyad of gestational age between 37 and 42 weeks. The weight loss pattern, maternal comfort, and LATCH score was compared between the two groups. Results Among 200 newborns, 55.5% were males and 44.5% were females. Study observed that there is no significant difference in mean weight loss between two positions; however, urine frequency between cradle group and cross-cradle group was statistically highly significant ( p-value <0.001). Cross-cradle breastfeeding position showed higher maternal comfort score and LATCH score than cradle breastfeeding position. Conclusion This study explores that cross-cradle breastfeeding position is better in terms of maternal comfort and baby’ latchment than cradle breastfeeding position.
Comparative Assessment of Fetal Malnutrition Using the Clinical Assessment of Nutritional Score and Anthropometry Among Newborns Delivered at Debre Markos Comprehensive Specialized  Hospital, Ethiopia
Authors: Sume Bickes Wube , Afework Mekbeb 
Published: October 2024

Background Fetal malnutrition (FM) is inability to gain a sufficient amount of muscle mass and stoutness during prenatal growth. It has both immediate and long-term effects in early neonatal and late adulthood. Objectives The aim of this study was to assess FM incidence using clinical nutritional assessment (CAN) score and evaluate CAN score with anthropometry to develop simple and reliable screening algorithm. Methods Institution-based study was carried out at Debre Markos Comprehensive Specialized Hospital (DMCSH). Only term singleton newborns were measured for weight, head circumference (HC), crown-heel length, and midarm circumference (MAC). Ponderal index (PI), body mass index (BMI), and MAC to HC ratio were computed. Nutritional status of newborns was evaluated using CAN score within 24 hours of delivery. Stata version 14 software was used for data analysis. Results In this study, 422 term newborns were participated. FM incidence was 13.74% by CAN score. About 15.40, 13.03, and 7.58% of malnourished newborns were identified through MAC/HC, BMI, and PI, respectively. Sensitivities of PI, MAC to HC, and BMI were 48.28, 81.03, and 86.21%, respectively. Specificities of PI, BMI, and MAC to HC were 98.90, 98.63, and 95.05%, respectively. Conclusions Almost one in every seven newborns had FM by the CAN score. The BMI had greatest sensitivity, while the PI exhibited highest specificity in detecting FM. Therefore, birth attendants lacking training in CAN score can rapidly assess FM using a combination of BMI and PI.
Distal Triceps Tendon Injury
Authors: Kholinne Erica 
Published: October 2024

Injuries to the distal triceps brachii tendon are rare, but they can be challenging to diagnose accurately. While imaging radiographs are commonly used to confirm physical examination findings and guide treatment, magnetic resonance imaging (MRI) is considered the gold standard for diagnostic imaging. However, the accuracy of MRI in distinguishing between partial and full-thickness tears of the distal triceps tendon is not very reliable. A recent study conducted from 2011 to 2015 involving eight patients with nine triceps tendon tears aimed to assess MRI's accuracy in this differentiation. The study revealed that MRI correctly identified all three surgically confirmed complete tears, but its accuracy in detecting partial tears was less reliable, correctly identifying only four out of six cases. Notably, two cases were mistakenly identified as complete tears by MRI but were found to be partial tears during surgery. The characteristics of the distal triceps brachii insertion on the olecranon are fascinating and provide valuable insights into the diagnostic challenges faced by clinicians. Therefore, a recent study included fourteen fresh-frozen elbows were dissected, and a histologic examination was conducted on the distal triceps brachii insertion. Concurrently, T1-weighted elbow MR images of 102 patients without triceps pathology were analyzed. The study found that there are three distinct insertional areas of the distal triceps brachii tendon on the olecranon: capsular, deep muscular, and superficial tendinous. The superficial tendinous insertion exhibited a thickened portion known as the "central cord." MR analysis revealed a cleft between the superficial tendinous and deep muscular insertions, designated as the "lacuna," in some cases. Understanding this anatomy can help surgeons identify partial triceps injuries and avoid iatrogenic injury during surgery. While MRI is valuable in diagnosis, it is not always accurate, and false-positive results are not uncommon. Therefore, it is crucial to combine clinical examination with imaging for accurate diagnosis and treatment planning. These findings highlight the importance of a comprehensive approach that includes clinical assessment, with MRI serving as a valuable adjunctive tool in the diagnostic process and treatment planning for distal triceps tendon injuries.
Functional Outcome in Primary Anterior Cruciate Ligament Repair versus Anterior Cruciate Ligament Reconstruction: A Meta-Analysis
Authors: Surya Pranata Ketut Gede Arya , Wien Aryana Gusti Ngurah 
Published: October 2024

Background: In recent years, interest in modern anterior cruciate ligament (ACL) suture repair procedures has increased. Although some clinical studies have produced positive short-term outcomes, there is a lack of high-quality information about the efficacy of this treatment in comparison to ACL reconstruction. We aim to compare the therapeutic effect of primary repair ACL injury with reconstruction and provide the reliable evidence for its clinical application. Methods: PubMed, EMBASE, Scopus, Web of Science and Google Scholar were searched for relevant studies from January 2019 to August 2023. This research will include English-language, randomized, controlled studies that compare functional outcome (IKDC subjective score, Lysholm Score, and Tegner score) in primary ACL repair versus ACL reconstruction. Result: Five studies were used ranging from 2019 to 2023 which discussed the comparison of the treatment of ACL rupture with primary ACL repair and ACL Reconstruction. Both group of Primary ACL Repair and ACL Reconstruction have a similar in outcome in Lysholme score and Tegner score. Meanwhile they have a significant differences in IKDC score which higher in ACL Reconstruction group compare to primary ACL repair group (9,63 points, 95% CI=7.54-11,72, p<0.00001) and a higher rate of complication on primary ACL repair than the ACL Reconstruction group. Conclusion: Primary ACL Repair and ACL Reconstruction have a difference functional outcome for IKDC score. While the choice for treatment is still depend to individual patient for some factors including severity of injury, patient age, activity level, graft choice, and long-term goals.
Functional Assessment with Blood Flow Restricted Therapy Following Anterior Cruciate Ligament Reconstruction at 8 Weeks Follow-Up: a Meta-Analysis
Authors: Dharmayuda Putu Angga , Wien Aryana I Gusti Ngurah 
Published: October 2024

Background: Quadriceps muscle atrophy with diminished muscle strength has been observed in patients underwent ACL reconstruction, despite following the regular physical rehabilitation. Blood flow restricted therapy has shown beneficial outcomes in attempts to prevent muscle atrophy and improve muscle strength in this population. Objective: The aim of study is to evaluate the functional outcome with blood flow restricted therapy following ACL reconstruction according to recent publications. Methods: This study conducted a thorough systematic search for relevant scientific reports on multiple medical databases, including PubMed, Embase, and Google Scholar, using a combination of keywords such as "blood flow restricted therapy," "ACL reconstruction," “IKDC,” "KOOS," and “Lysholm”. The search was performed in April 2013-2023, resulted in 557 studies. Two reviewers (WA, PA) independently screened the abstracts and reference lists, with any discrepancies resolved through consensus, concluding 4 included studies. Results: Four studies included studies are included with a total 80 patients consisting of 41 patients treated with blood flow restricted therapy (BFRT) and 39 patients treated with regular physical rehabilitation following an ACL reconstruction. At 8 weeks follow-up, there are overall satisfactorily functional outcomes, including IKDC, KOOS, and Lysholm score favoring BFRT. Conclusion: Blood flow restriction therapy is applicable for physical rehabilitation technique following ACL reconstruction. It provides beneficial adjunct to surgical ACL reconstruction with satisfactory results.
How the marketing of real estate properties explains mortgage applicants by race and income
Authors: Nilsson Isabelle , Delmelle Elizabeth C 
Published: October 2024

In this article, we study how the marketing of single-family homes explains the racial and income makeup of mortgage applicants in a neighborhood. We use a case study of the robust housing market of Charlotte, North Carolina, and annual, longitudinal real estate listing advertisements alongside mortgage lending data, to demonstrate how the share of properties advertised a certain way in a neighborhood in 1 year explains shares of mortgage applicants by race and income the following year. We classify property advertisement text using a semi-supervised learning algorithm into five categories following a housing investment and disinvestment to renewal continuum. We find stark racial disparities in mortgage applicants by housing type, even after controlling for income. We find that Black applicants nearly exclusively apply for mortgages in neighborhoods with a high share of properties advertised as disinvested with little profit-making promise. High-income White applicants rise as the share of advertised properties becomes more homogenous.
Measuring Superficial Pelvic Floor Muscle Properties Using Transperineal Grayscale and Sonographic Elastography: A Feasibility Study
Authors: Kadah Shaza , Lever Frauke , Soh Sze-Ee , Lin Kuan-Yin , Frawley Helena 
Published: October 2024

Objective: The objective was to test the feasibility and acceptability of a novel protocol to measure the properties of the superficial pelvic floor muscles (sPFMs) using grayscale ultrasonography (US), point shear-wave elastography (pSWE), and strain elastography (SE). Materials and Methods: This was an observational feasibility study. Feasibility was determined by assessing the number of US images acquired to measure sPFM properties using these tools. Thickness of the sPFMs was assessed using grayscale US, while stiffness and elasticity were measured using pSWE and SE. Results: Twenty-six women participated in this study. The US image acquisitions and analyses of sPFM properties were completed in 96% (25 of 26) of women. Several challenges related to the morphological characteristics of sPFM or the US assessment tools were encountered. When measuring the bulbospongiosus muscle, both the muscle and bulb of the clitoris were captured (they moved and contracted similarly and simultaneously). The small size of the ischiocavernosus and superficial transverse perineal muscles also made measuring stiffness challenging. Conclusion: Challenges were encountered when measuring the sPFMs using grayscale US, pSWE, and SE. Further studies are required to optimize the protocol to evaluate individual sPFM properties using these tools, with Duplex Doppler potentially valuable to distinguish between vascular and sPFM structures.
Cryo-EM structure of the human native plasma coagulation factor XIII complex
Authors: Singh Sneha , Hagelueken Gregor , Ugurlar Deniz , Ramaraje Urs Samhitha Urs , Sharma Amit , Mahapatra Manoranjan , Drepper Friedel , Imhof Diana , Huesgen Pitter F. , Oldenburg Johannes , Geyer Matthias , Biswas Arijit 
Published: October 2024

Abstract
The structure of human coagulation factor XIII (FXIII), a heterotetrameric plasma protransglutaminase that covalently cross-links preformed fibrin polymers, remains elusive until today. The heterotetrameric complex is composed of 2 catalytic FXIII-A and 2 protective FXIII-B subunits. Structural etiology underlying FXIII deficiency has so far been derived from crystallographic structures, all of which are currently available for the FXIII-A2 homodimer only. Here, we present the cryogenic electron microscopy (cryo-EM) structure of a native, human plasma–derived FXIII-A2B2 complex at 2.4 Å resolution. The structure provides detailed information on FXIII subunit interacting interfaces as the 2 subunits interact strongly in plasma. The native FXIII-A2B2 complex reveals a pseudosymmetric heterotetramer of 2 FXIII-B monomers intercalating with a symmetric FXIII-A2 dimer forming a “crown”-like assembly. The symmetry axes of the A2 and B2 homodimers are twisted relative to each other such that Sushi domain 1 interacts with the catalytic core of the A subunit, and Sushi domain 2 with the symmetry related A′ subunit, and vice versa. We also report 4 novel mutations in the F13A1 gene encoding the FXIII-A subunit from a cohort of patients with severe FXIII deficiency. Our structure reveals the etiological basis of homozygous and heterozygous pathogenic mutations and explains the conditional dominant negative effects of heterozygous mutations. This atomistic description of complex interfaces is consistent with previous biochemical data and shows a congruence between the structural biochemistry of the FXIII complex and the clinical features of FXIII deficiency.
Differences in the effectiveness of leukocyte-rich platelet-rich plasma compared with leukocyte-poor platelet-rich plasma in the treatment of rotator cuff surgery: an umbrella review of meta-analyses
Authors: Tang Peiyuan , Rahmati Masoud , Xiao Wenfeng , Wen Ting , Yon Dong Keon , Smith Lee , Su Jingyue , Yang Shengwu , Li Yusheng , Deng Zhenhan 
Published: October 2024

Abstract
Background
An umbrella review of meta-analyses was conducted to evaluate the use of platelet-rich plasma (PRP) in arthroscopic surgeries of rotator cuff injury. The effectiveness of leukocyte-poor PRP and leukocyte-rich PRP in the treatment of rotator cuff surgery was also compared.

Methods
Web of Science, Embase, PubMed/MEDLINE, and the Cochrane Library were searched from inception to May 2024. Literature screening, quality evaluation, and data extraction were performed according to the inclusion and exclusion criteria. The Jadad decision algorithm was used to ascertain which meta-analysis represented the best evidence.

Results
A total of 11 meta-analyses with evidence level ranging from level 1 to 2 were included in this umbrella review. Leukocyte-poor PRP was effective in reducing rotator cuff retear rates, alleviating pain, and increasing Constant scores compared with non-PRP treatments. However, it did not show improvement on the University of California Los Angeles (UCLA) score, the American Shoulder and Elbow Surgeons (ASES) score, and the Simple Shoulder Test (SST) compared with the non-PRP treatment group. Meanwhile, the leukocyte-rich PRP group improved the SST but showed no different results when compared with the non-PRP treatment group.

Conclusion
Compared with no use of PRP, leukocyte-poor PRP was able to alleviate postoperative pain, reduce the retear rate, and improve the postoperative Constant score. Leukocyte-rich PRP could effectively enhance postoperative SST outcomes, leading to improvement of patient satisfaction and quality of life. Future researches should prioritize long-term follow-up studies and evaluate the durability of these results.
Patients´ experiences of an exercise intervention in primary care following robot-assisted radical cystectomy due to bladder cancer: a qualitative study
Authors: Karlsson Patrik , Nygren-Bonnier Malin , Torikka Simon , Porserud Andrea , Henningsohn Lars , Olsson Christina B. , Rydwik Elisabeth , Hagströmer Maria 
Published: October 2024

Abstract
Background
Physical activity is thought to be a key component in reducing postoperative complications following major abdominal surgery. The available literature on exercise interventions following radical cystectomy in patients with bladder cancer is scarce but suggests that physical activity and exercise might improve physical function and health-related quality of life, thus calling for further investigation. The CanMoRe-trial is a single-blinded randomised controlled trial (Clinicals Trials NCT03998579 25/06/2019), aimed at evaluating the impact of an exercise intervention in primary care following robot-assisted radical cystectomy. This study seeks to explore patients’ experiences of the exercise intervention in the CanMoRe-trial to gain a better understanding of facilitating aspects and potential barriers.

Methods
A qualitative study was conducted involving 20 patients from the intervention group of the CanMoRe-trial who were interviewed individually between October 2020 and March 2023 using a semi-structured interview guide. The interviews were recorded and transcribed verbatim and reflexive thematic analysis was used to analyse the data.

Results
Four main themes were identified: Having to adapt to new circumstances, describing the challenges regarding physical activity patients face after discharge. Optimising conditions for rehabilitation, describing how practical conditions affect patients’ ability to exercise. Motivated to get back to normal, describing patients´ desire to get back to normal life and factors influencing motivation. Importance of a supportive environment, describing the impact of social support, support from physiotherapists, and how the environment where exercise takes place impacts patients’ ability to exercise.

Conclusion
This study found that patients participating in the CanMoRe-trial are positive towards physical exercise in PC following radical RARC. They are motivated to get back to normal life but face major challenges when arriving home following surgery, which affect their ability to perform physical activity and engage in exercise. Conditions need to be optimised to support patients’ ability to engage in exercise by providing an accessible PC location to perform exercise in. A supportive environment is also needed, including guidance from healthcare professionals regarding which type of exercise, intensity and amount of exercise that should be performed, enabling patients gradually to develop self-efficacy regarding exercise and focusing on goals related to patients’ normal lives before surgery.