bluuebunny/crossref_metadata_2025_split huggingface dataset:
Masses of transuranium nuclides measured with the PI-ICR technique at TRIGA-Trap
Authors: Chenmarev S. , Blaum K. , Block M. , Cakirli R. B. , Düllmann Ch. E. , Gutiérrez M. J. , Nagy Sz. , Renisch D. 
Published: October 2024

AbstractWe have revisited the region of the actinides in the vicinity of the neutron number N=152 and conducted high-precision mass measurements using the newly implemented Phase-Imaging Ion-Cyclotron-Resonance (PI-ICR) technique. The masses of $$^{244}$$

244

Pu and $$^{249}$$

249

Cf were found to deviate by 5.4 and 2.9 combined sigmas, respectively, from our previous results published in 2014. This indicates the presence of systematic errors in the earlier measurements. Consequently, we decided to remeasure all the nuclides from our 2014 study, along with $$^{248}$$

248

Cm, to ensure accuracy and reliability. With our greatly improved apparatus, we have measured the masses of $$^{244}$$

244

Pu, $$^{241}$$

241

Am, $$^{243}$$

243

Am, $$^{248}$$

248

Cm, and $$^{249}$$

249

Cf, using $$^{208}$$

208

Pb and $$^{238}$$

238

U as mass references. The masses of these reference ions were recently determined with ultra-high precision at Pentatrap. Our results were implemented in the latest Atomic Mass Evaluation (AME), showing good consistency. The region related to the masses measured in this study, especially for isotopes near the N=152 deformed shell gap, is discussed in terms of two-neutron separation energies, first excited 2$$^+$$

+

energy levels and their differentials, as well as $$\delta V_{pn}$$

δ

V

pn

values, the average proton-neutron interaction of the most loosely bound two nucleons.
Effects of gravity rainbow on scalar bosonic and oscillator fields in Bonnor–Melvin space-time with a cosmological constant
Authors: Ahmed Faizuddin , Bouzenada Abdelmalek 
Published: October 2024

AbstractIn this paper, we explore the relativistic quantum motion of spin-zero scalar charge-free particles influenced by rainbow gravity’s (RG’s) in Bonnor–Melvin magnetic space-time, a four-dimensional solution featuring a positive cosmological constant. We solve the Klein–Gordon equation in this scenario by using two sets of rainbow function: (i) $$f(\chi )=\frac{1}{(1-\beta \,\chi )}$$

f

(
χ
)

=

1

(
1
-
β

χ
)

, $$h(\chi )=1$$

h
(
χ
)
=
1

and (ii) $$f(\chi )=\frac{1}{(1-\beta \,\chi )}=h(\chi )$$

f

(
χ
)

=

1

(
1
-
β

χ
)

=
h

(
χ
)

, where $$0 < \chi \left( =\frac{|E|}{E_p}\right) \le 1$$

0
<
χ

=

|
E
|

E
p

≤
1

with $$E_p$$

E
p

being the Planck’s energy, E is the particle’s energy, and $$\beta $$
β
is the rainbow parameter. Furthermore, we study the relativistic quantum oscillator through the Klein–Gordon oscillator equation in the same Bonnor–Melvin magnetic space-time under RG effects. Employing the first pair of rainbow function, we obtain an approximate eigenvalue solution of the quantum oscillator fields. Notably, we demonstrate that the relativistic energy profile of scalar and oscillator particles are influenced by the topology of the geometry and the cosmological constant which is related with the magnetic field strength lies along the symmetry axis. Additionally, we see the impact of rainbow parameter on these approximate relativistic energy profiles in both quantum systems.
A simple model of magnetic universe without singularity associated with a quadratic equation of state
Authors: Chavanis Pierre-Henri 
Published: October 2024

AbstractA model of magnetic universe based on nonlinear electrodynamics has been introduced by Kruglov (Phys Rev D 92:123523, 2015). This model describes an early inflation era followed by a radiation era. We show that this model is related to the model of universe based on a quadratic equation of state introduced in our previous paper (Chavanis in Universe 1:357, 2015). This correspondence may provide a more fundamental justification of our equation of state. It may arise from quantum corrections to linear electrodynamics when the electromagnetic field becomes very high. We discuss two quantitatively different models of early universe. In Model I, the primordial density of the universe is identified with the Planck density. At $$t=0$$

t
=
0

, the universe had the characteristics of a Planck black hole (“planckion” particle). During the inflation, which takes place on a Planck timescale, the size of the universe evolves from the Planck length to a size comparable to the Compton wavelength of the neutrino. If we interpret the radius of the universe at the end of the inflation (neutrino’s Compton wavelength) as a minimum length related to quantum gravity and use Zeldovich’s first formula of the vacuum energy, we obtain the correct value of the cosmological constant. In Model II, the primordial density of the universe is identified with the electron density as a consequence of nonlinear electrodynamics. At $$t=0$$

t
=
0

, the universe had the characteristics of an electron. This can be viewed as a refinement of the “primeval atom” of Lemaître. During the inflation, which takes place on a gravitoelectronic timescale, the size of the universe evolves from the electron’s classical radius to a size comparable to the size of a dark energy star of the stellar mass. If we interpret the radius of the universe at the beginning of the inflation (electron’s classical radius) as a minimum length related to quantum gravity and use Zeldovich’s second formula of the vacuum energy, we obtain the correct value of the cosmological constant. This provides an accurate form of Eddington’s relation between the cosmological constant and the mass of the electron. We use these arguments to show that the present universe contains about $$10^{80}$$

10
80

protons (Eddington’s number). We also introduce a nonlinear electromagnetic Lagrangian that describes simultaneously the early inflation, the radiation era, and the dark energy era. It may account for a form of “generalized radiation” that is present from the beginning to the end of the cosmic evolution. Baryonic and dark matter are treated as independent noninteracting species. The dark energy era is due to the electromagnetic vacuum energy (zero-point radiation). In this approach, both the early inflation and the late acceleration of the universe (dark energy) arise as a consequence of nonlinear electrodynamics. This leads to a simple model of magnetic universe without singularity (aioniotic universe).
Exact solutions of the (3+1)-dimensional DKP oscillator in doubly special relativity
Authors: Seffai D. , Hamil B. , Merad M. 
Published: October 2024

Doubly Special Relativity (DSR) is a promising candidate for understanding quantum gravity, by introducing two fundamental invariant scales — the speed of light and the Planck energy. Recently, another such theory has been proposed by Magueijo and Smolin (MS), and it can be extended to the whole class of DSRs. These models have structural similarity with different realizations of [Formula: see text]-Poincaré algebras. Given the significant implications of this theory, we explore the three-dimensional Duffin–Kemmer–Petiau (DKP) oscillator within this framework. By using the vector spherical harmonics technique in the momentum space, the three-dimensional DKP oscillator equation for spins 1 and 0 is reformulated from the viewpoint of the generalized algebra of the MS model. In order to recognize the influence of this reformulation, the energy eigenvalues contain an additional correction which depends on the deformation parameter, and eigenfunctions are determined in terms of the associated Laguerre polynomials.
A Small-Molecule BCL6 Inhibitor as an Anti-Proliferative Agent for Diffuse Large B-Cell Lymphoma
Authors: Xing Yajing , Guo Weikai , Wu Min , Xie Jiuqing , Huang Dongxia , Hu Pan , Zhou Miaoran , Zhang Lin , Zhong Yadong , Liu Mingyao , Chen Yihua , Yi Zhengfang 
Published: October 2024

Abstract
The B-cell lymphoma 6 (BCL6) transcription factor plays a key role in the establishment of germinal center (GC) formation. Diffuse large B-cell lymphoma (DLBCL) originates from the GC reaction due to dysregulation of BCL6. Disrupting BCL6 and its corepressors’ interaction has become the foundation for rationally designing lymphoma therapies. However, BCL6 inhibitors with good activities in vitro and in vivo are rare, and there are no clinically approved BCL6 inhibitors. In this study, we discovered and developed a novel range of [1,2,4] triazolo[1,5-a] pyrimidine derivatives targeting BCL6/SMRT interaction. The lead compound WK692 directly bound BCL6BTB, disrupted BCL6BTB/SMRT interaction and activated the expression of BCL6 downstream genes inside cells, inhibited DLBCL growth and induced apoptosis in vitro, inhibited GC formation, decreased the proportion of follicular helper T cells, and impaired Ig affinity maturation. Further studies showed that WK692 inhibits DLBCL growth without toxic effects in vivo and synergizes with the EZH2 and PRMT5 inhibitors. Our results demonstrated that WK692 as a BCL6 inhibitor may be developed as a novel potential anticancer agent against DLBCL.
ASGR1 Deficiency Inhibits Atherosclerosis in Western Diet–Fed

ApoE
−/−

Mice by Regulating Lipoprotein Metabolism and Promoting Cholesterol Efflux
Authors: Zhang Yuyan , Jiang Xinhai , Wang Weizhi , Lei Lijuan , Sheng Ren , Li Shunwang , Luo Jinque , Liu Huan , Zhang Jing , Han Xiaowan , Li Yining , Zhang Yuhao , Wang Chenyin , Si Shuyi , Jin Zheng-Gen , Xu Yanni 
Published: October 2024

BACKGROUND:
Atherosclerosis is the most common cause of cardiovascular diseases. Clinical studies indicate that loss-of-function ASGR1 (asialoglycoprotein receptor 1) is significantly associated with lower plasma cholesterol levels and reduces cardiovascular disease risk. However, the effect of ASGR1 on atherosclerosis remains incompletely understood; whether inhibition of ASGR1 causes liver injury remains controversial. Here, we comprehensively investigated the effects and the underlying molecular mechanisms of ASGR1 deficiency and overexpression on atherosclerosis and liver injury in mice.

METHODS:

We engineered
Asgr1
knockout mice (
Asgr1

−/−

),
Asgr1
and
ApoE
double-knockout mice (
Asgr1

−/−

ApoE

−/−

), and ASGR1-overexpressing mice on an
ApoE

−/−

background and then fed them different diets to assess the role of ASGR1 in atherosclerosis and liver injury.

RESULTS:

After being fed a Western diet for 12 weeks,
Asgr1

−/−

ApoE

−/−

mice exhibited significantly decreased atherosclerotic lesion areas in the aorta and aortic root sections, reduced plasma VLDL (very-low-density lipoprotein) cholesterol and LDL (low-density lipoprotein) cholesterol levels, decreased VLDL production, and increased fecal cholesterol contents. Conversely, ASGR1 overexpression in
ApoE

−/−

mice increased atherosclerotic lesions in the aorta and aortic root sections, augmented plasma VLDL cholesterol and LDL cholesterol levels and VLDL production, and decreased fecal cholesterol contents. Mechanistically, ASGR1 deficiency reduced VLDL production by inhibiting the expression of MTTP (microsomal triglyceride transfer protein) and ANGPTL3 (angiopoietin-like protein 3)/ANGPTL8 (angiopoietin-like protein 8) but increasing LPL (lipoprotein lipase) activity, increased LDL uptake by increasing LDLR (LDL receptor) expression, and promoted cholesterol efflux through increasing expression of LXRα (liver X receptor-α), ABCA1 (ATP-binding cassette subfamily A member 1), ABCG5 (ATP-binding cassette subfamily G member 5), and CYP7A1 (cytochrome P450 family 7 subfamily A member 1). These underlying alterations were confirmed in ASGR1-overexpressing
ApoE

−/−

mice. In addition, ASGR1 deficiency exacerbates liver injury in Western diet–induced
Asgr1

−/−

ApoE

−/−

mice and high-fat diet–induced but not normal laboratory diet–induced and high-fat and high-cholesterol diet–induced
Asgr1

−/−

mice, while its overexpression mitigates liver injury in Western diet–induced ASGR1-overexpressing
ApoE

−/−

mice.

CONCLUSIONS:

Inhibition of ASGR1 inhibits atherosclerosis in Western diet–fed
ApoE

−/−

mice, suggesting that inhibiting ASGR1 may serve as a novel therapeutic strategy to treat atherosclerosis and cardiovascular diseases.
Immunoregulatory Macrophages Modify Local Pulmonary Immunity and Ameliorate Hypoxic Pulmonary Hypertension
Authors: Fernandez-Gonzalez Angeles , Mukhia Amit , Nadkarni Janhavi , Willis Gareth R. , Reis Monica , Zhumka Kristjan , Vitali Sally , Liu Xianlan , Galls Alexandra , Mitsialis S. Alex , Kourembanas Stella 
Published: October 2024

BACKGROUND:
Macrophages play a significant role in the onset and progression of vascular disease in pulmonary hypertension, and cell-based immunotherapies aimed at treating vascular remodeling are lacking. We aimed to evaluate the effect of pulmonary administration of macrophages modified to have an anti-inflammatory/proresolving phenotype in attenuating early pulmonary inflammation and progression of experimentally induced pulmonary hypertension.

METHODS:

Mouse bone marrow–derived macrophages were polarized in vitro to a regulatory (M2
reg
) phenotype. M2
reg
profile and anti-inflammatory capacity were assessed in vitro upon lipopolysaccharide/IFNγ (interferon-γ) restimulation, before their administration to 8- to 12-week-old mice. M2
reg
protective effect was evaluated at early (2–4 days) and late (4 weeks) time points during hypoxia (8.5% O
2
) exposure. Levels of inflammatory markers were quantified in alveolar macrophages and whole lung, while pulmonary hypertension development was ascertained by right ventricular systolic pressure (RVSP) and right ventricular hypertrophy measurements. Bronchoalveolar lavage from M2
reg
-transplanted hypoxic mice was collected and its inflammatory potential evaluated on naive bone marrow–derived macrophages.

RESULTS:

M2
reg
macrophages expressing
Tgf
β,
Il10
, and
Cd206
demonstrated a stable anti-inflammatory phenotype in vitro, by downregulating the induction of proinflammatory cytokines and surface molecules (
Cd86
,
Il6
, and
Tnf
α) upon a subsequent proinflammatory stimulus. A single dose of M2
regs
attenuated hypoxic monocytic recruitment and perivascular inflammation. Early hypoxic lung and alveolar macrophage inflammation leading to pulmonary hypertension development was significantly reduced, and, importantly, M2
regs
attenuated right ventricular hypertrophy, right ventricular systolic pressure, and vascular remodeling at 4 weeks post-treatment.

CONCLUSIONS:

Adoptive transfer of M2
regs
halts the recruitment of monocytes and modifies the hypoxic lung microenvironment, potentially changing the immunoreactivity of recruited macrophages and restoring normal immune functionality of the lung. These findings provide new mechanistic insights into the diverse role of macrophage phenotype on lung vascular homeostasis that can be explored as novel therapeutic targets.
Dual Antiplatelet Versus Alteplase for Early Neurologic Deterioration in Minor Stroke With Versus Without Large Vessel Occlusion: Prespecified Post Hoc Analysis of the ARAMIS Trial
Authors: Cui Yu , He Chao , Li Zi-Ang , Wang Yue , Chen Hui-Sheng 
Published: October 2024

BACKGROUND:
Dual antiplatelet therapy (DAPT) was noninferior to alteplase in minor nondisabling strokes in the ARAMIS trial (Antiplatelet Versus R-tPA for Acute Mild Ischemic Stroke); however, early neurological deterioration (END) associated with vessel stenosis may benefit from DAPT. We investigated whether the efficacy of DAPT was greater than alteplase in minor strokes with no large vessel occlusion (LVO).

METHODS:
This study was a prespecified post hoc analysis of the ARAMIS trial and included patients with responsible vessel examination in the as-treated analysis set of the ARAMIS trial who were divided into LVO group and non-LVO group. In each group, patients were further classified into DAPT and intravenous alteplase treatments. Primary outcome was END at 24 hours defined as more than or equal to 4-point National Institutes of Health Stroke Scale score increase compared with baseline, and safety outcomes were symptomatic intracerebral hemorrhage and bleeding events during study. The primary analysis was estimated with a risk difference calculated by a generalized linear model including adjusted different baseline characteristics between treatments.

RESULTS:

Of 723 patients from the ARAMIS trial, 480 patients were included: 36 were categorized into LVO group and 444 into non-LVO group, of whom 20 patients had END. Compared with intravenous alteplase, a lower proportion of END was found after DAPT treatment in the non-LVO group (adjusted risk difference, −4.8% [95% CI, −6.9% to −2.6%];
P
<0.001), but not in the LVO group (adjusted risk difference, 2.3% [95% CI, −17.6% to 22.3%];
P
=0.82). The interaction was marginally significant between groups (
P
=0.06). In the non-LVO group, a lower proportion of bleeding events was found after DAPT treatment than intravenous alteplase (adjusted risk difference, −6.4% [95% CI, −8.9% to −3.9%];
P
<0.001). Other safety outcomes were similar between the 2 treatments.

CONCLUSIONS:
Among minor nondisabling acute ischemic stroke without LVO, DAPT may be superior to intravenous alteplase regarding preventing END with a better safety profile.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03661411.
Not Eliminate but Aggregate: Post-Hoc Control over Mixture-of-Experts to Address Shortcut Shifts in Natural Language Understanding
Authors: Honda Ukyo , Oka Tatsushi , Zhang Peinan , Mita Masato 
Published: October 2024

Abstract
Recent models for natural language understanding are inclined to exploit simple patterns in datasets, commonly known as shortcuts. These shortcuts hinge on spurious correlations between labels and latent features existing in the training data. At inference time, shortcut-dependent models are likely to generate erroneous predictions under distribution shifts, particularly when some latent features are no longer correlated with the labels. To avoid this, previous studies have trained models to eliminate the reliance on shortcuts. In this study, we explore a different direction: pessimistically aggregating the predictions of a mixture-of-experts, assuming each expert captures relatively different latent features. The experimental results demonstrate that our post-hoc control over the experts significantly enhances the model’s robustness to the distribution shift in shortcuts. Additionally, we show that our approach has some practical advantages. We also analyze our model and provide results to support the assumption.1
Southernmost record and diet of Leptobrachella eos (Ohler, Woollen, Grosjean, Hendrix, Vences, Ziegler & Dubois, 2011) in Vietnam
Authors: Pham Anh Van , Le Minh Duc , Ho Anh Ngoc Thi , Nguyen Truong Quang , Nguyen Tham Thi , Ziegler Thomas , Tran Cuong Thien , Pham Cuong The 
Published: October 2024

Abstract
The Rosy Litter Frog (Leptobrachella eos) is known from Thailand, Laos, and Vietnam. Knowledge about the natural history of this species is virtually lacking. As a result of our field work in Son La, Nghe An, and Ha Tinh provinces of Vietnam, we provide data on the food composition of L. eos for the first time. Using the stomach-flushing method, we analyzed stomach contents of 34 individuals (23 males and 11 females) from a total of 42 frogs, with stomachs of five males and three females (19%) being empty. A total of 13 prey categories were observed in the stomachs of L. eos, with 232 items, comprising 230 items of invertebrates and two unidentified items. The most important (IRI) groups among the prey of L. eos were Blattodea (26.31%), Araneae (17.26%), Orthoptera (13.21%), Coleoptera (12.39%), and Opiliones (10.09%). There was an overlap of 51.11 % in the diet between males and females, The trophic spectrum of males comprising 11 prey categories revealed to be wider than that of females comprising nine prey categories. Despite differences in diets between the sexes, Blattodea, Orthoptera, Araneae, Coleoptera, and Opiliones represented the most important prey category for all of them. In addition, we also report a new find of Leptobrachella eos, with a new subpopulation from Ha Tinh Province, Vietnam.
Challenges of Private International Law in Asia
Authors: Nishitani Yuko 
Published: October 2024

Abstract
The presence of Asia in the global arena has become notable due to its thriving economy. Arguably, it is time to consider how private international law (or conflict of laws) should develop in Asia and what kind of opportunity it can engender, considering that private international law has the potential to promote economic and legal cooperation without unifying substantive law. First, this paper considers the role of the Hague Conference on Private International Law (HCCH) and the varying significance of its conventions on judicial assistance, litigation, and child protection in the pursuit of private international law unification in Asia. Second, this study elaborates and supports the use of non-binding instruments (or soft law) – model laws, principles, legislative guides, etc. – as a fallback method of harmonizing private international law. Third, this paper examines the increasing extraterritoriality of regulatory norms of the US, the EU, China, and other countries in the global market. This will clarify the problems of conflicting, overlapping regulations and allow scrutiny of potential pathways to restrict the exercise of the states’ prescriptive jurisdiction. Some future perspectives will conclude this study.
Admissibility of ILA Principles on Intellectual Property and Private International Law in Vietnam
Authors: Trang Bui Thi Quynh , Nguyen Phan Dinh , Trinh Nguyen Thi Hong 
Published: October 2024

Abstract
Private law on intellectual property (IP) has achieved significant international harmonization, but international jurisdiction is subject to national regulations. As a result, enforcement of IP rights is carried out on a country-by-country basis. This approach leads to multiple concurrent legal proceedings, increasing the risk of conflicting judgments and escalating litigation costs. These costs create a disparity between multinational corporations and small and medium-sized enterprises. As a potential model for future international agreements on intellectual property and private international law, the International Law Association (ILA) Committee on ‘Intellectual Property and Private International Law’ seeks to address cross-border IP disputes. This paper will explore whether the ILA principles can be utilized as models for legislators, judges, arbitrators and other competent authorities in Vietnam, a legal system characterized by a lack of case law on the topic.