bluuebunny/crossref_metadata_2025_split huggingface dataset:
Homeopathy, Mythology and Poetry: Towards an Understanding of How Art, Myth and Homeopathy Are Inextricably Connected, with Special Reference to the Work of TS Eliot
Authors: Hamilton Ian 
Published: December 2017

AbstractThis is another article of what we hope will be a series of interesting contributions about the relationship between art and homeopathy and the art and science of homeopathy. Many have noted this connection between art and homeopathy, and there is something about the nature of the creative force and the way in which we perceive the vital force as creative, which puts homeopathy in the same dynamic place as that which drives artistic inspiration. We would like readers to reflect on these connections and how they may have experienced, used or made art a focus of their homeopathic practice and understanding. I know from starting my group ‘Art and Homeopathy’ that the direction of our own work is diverse, but all is founded on the principle of using art in some way to clarify and enhance practice. We invite you to send us your experience or take on this, be you artist, homeopath or both. This article tries to explain how art, homeopathy and myth are totally interconnected.
Management of Cerebral Edema in Acute Liver Failure
Authors: Kok Beverley , Karvellas Constantine 
Published: December 2017

AbstractAdvances in medical care of the acute liver failure patient have led to a significant reduction in mortality related to the condition. Nevertheless, cerebral edema and ensuing brain herniation remains one of the top causes of demise in acute liver failure. Controversy remains regarding the utility of invasive intracranial pressure monitoring as well as usage of novel treatment modalities including therapeutic hypothermia. This review provides a brief summary into the pathophysiology and risk factors for developing cerebral edema in the context of acute liver failure; this review particularly provides a practical focus on general management of the patient with established cerebral edema as well as specific intracranial pressure-lowering strategies.
Wie wirken Balintgruppen?*
Authors: Tschuschke Volker , Flatten Guido 
Published: December 2017

ZusammenfassungAls positive Effekte der Balintgruppenarbeit finden sich in Studien patientenbezogene Aspekte wie Empathie und verbessertes Zuhören, aber auch arztbezogene Verbesserungen des Selbstvertrauens und der Arbeitszufriedenheit. Mit der Entwicklung des Balintgruppen-Fragebogens BG-F konnten in einer aktuellen Studie 1460 ärztliche Teilnehmer in 352 unterschiedlichen Balintgruppen untersucht werden und eine differenzielle Wirksamkeit der Balintgruppenarbeit auf den 3 Skalen des BG-F nachgewiesen werden. Insbesondere somatisch tätige Ärzte und fallvorstellende Ärzte zeigen signifikante Effekte für eine verbesserte Reflexion der Übertragungsdynamiken sowie emotionales und kognitives Lernen. Teilnehmer mit längerer Balintgruppenerfahrung zeigen sich mehr geübt im Erkennen von Beziehungsdynamiken und Spiegelungseffekten in der Balintgruppenarbeit. Die Ergebnisse der Studie bestätigen wichtige Zielsetzungen der Balintgruppenarbeit zur Verbesserung der kommunikativen ärztlichen Kompetenz.
Interaktionelle Fallarbeit zwischen verhaltenstherapeutischer Supervision und Selbsterfahrung
Authors: Ehrig Christian 
Published: December 2017

ZusammenfassungDie IFA-Gruppe wurde in den letzten beiden Jahrzehnten als verhaltenstherapeutische Alternative zur Balint-Gruppenarbeit entwickelt. Sie bezieht sich dabei allerdings eindeutig auf die Herkunft aus der Balint-Gruppenarbeit. Grund für diese Entwicklung war der damalige Mangel an Supervisionsansätzen in der Verhaltenstherapie, die auf die interaktionellen Aspekte der Therapeut-Patienten-Beziehung fokussierten. Die IFA-Gruppe versteht sich als eine verhaltenstherapeutische Gruppensupervision, die neben der Supervision auch Selbsterfahrung ermöglicht und anregt. Dementsprechend vielfältig sind die notwendigen Qualifikationen und Kompetenzen des IFA-Gruppenleiters als erfahrener Gruppenleiter, Supervisor und Selbsterfahrungsleiter.
Ernährung und Mangelernährung im Alter
Authors: Franz Kristina , Müller-Werdan Ursula , Norman Kristina 
Published: December 2017

ZusammenfassungSenioren haben häufig aufgrund altersphysiologischer Veränderungen, sozioökonomischer, kognitiver oder psychischer Faktoren ein erhöhtes
Risiko für einen schlechten Ernährungszustand. Dadurch sind sie anfälliger für Infektionen und Komplikationen im Verlauf von Erkrankungen,
die zu verlängerten Genesungszeiten und reduzierter Lebensqualität führen. Da eine Mangelernährung im Alter multifaktorielle Ursachen hat,
sind für die optimale Ernährungsversorgung in der Geriatrie interdisziplinäre Maßnahmen von Bedeutung.
Quantitative Determination of Δ9-THC, CBG, CBD, Their Acid Precursors and Five Other Neutral Cannabinoids by UHPLC-UV-MS
Authors: Wang Yan-Hong , Avula Bharathi , ElSohly Mahmoud , Radwan Mohamed , Wang Mei , Wanas Amira , Mehmedic Zlatko , Khan Ikhlas 
Published: December 2017

AbstractCannabinoids are a group of terpenophenolic compounds in the medicinal plant Cannabis sativa (Cannabaceae family). Cannabigerolic acid, Δ9-tetrahydrocannabinolic acid A, cannabidiolic acid, Δ9-tetrahydrocannabinol, cannabigerol, cannabidiol, cannabichromene, and tetrahydrocannabivarin are major metabolites in the classification of different strains of C. sativa. Degradation or artifact cannabinoids cannabinol, cannabicyclol, and Δ8-tetrahydrocannabinol are formed under the influence of heat and light during processing and storage of the plant sample. An ultrahigh-performance liquid chromatographic method coupled with photodiode array and single quadruple mass spectrometry detectors was developed and validated for quantitative determination of 11 cannabinoids in different C. sativa samples. Compounds 1 – 11 were baseline separated with an acetonitrile (with 0.05% formic acid) and water (with 0.05% formic acid) gradient at a flow rate of 0.25 mL/min on a Waters Cortec UPLC C18 column (100 mm × 2.1 mm I. D., 1.6 µm). The limits of detection and limits of quantitation of the 11 cannabinoids were below 0.2 and 0.5 µg/mL, respectively. The relative standard deviation for the precision test was below 2.4%. A mixture of acetonitrile and methanol (80 : 20, v/v) was proven to be the best solvent system for the sample preparation. The recovery of all analytes was in the range of 97 – 105%. A total of 32 Cannabis samples including hashish, leaves, and flower buds were analyzed.
Lumpy species coexistence arises robustly in fluctuating resource environments
Authors: Sakavara Athanasia , Tsirtsis George , Roelke Daniel L. , Mancy Rebecca , Spatharis Sofie 
Published: December 2017

Significance
Explaining why there are more species than limiting resources in natural systems constitutes a long-standing challenge among ecologists. Recently, this apparent paradox was resolved theoretically by showing that species can coexist in clumps along niche gradients. However, models demonstrating this effect have failed to account for a ubiquitous feature of nature, namely variability in environmental conditions. This leaves open the question of whether the proposed mechanisms underpinning “lumpy coexistence” apply in nature or arise as a coincidence of modeling frameworks. Here, we demonstrate the emergence of lumpy coexistence in assemblages self-organizing under fluctuating resource supplies. We show that clumps form predictably as the result of the dynamic pattern in ambient resources driven by the most competitive species in the assemblage.
The struggles of precarious youth in Tunisia: the case of the Kerkennah movement
Authors: Feltrin Lorenzo 
Published: December 2017

ABSTRACT
This article analyses the origins and the dynamics of the social movement against the energy corporation Petrofac that took place in the Tunisian archipelago of Kerkennah between 2011 and 2016. The Kerkennah movement is seen as part of a broader cycle of mobilisations for social justice that started in 2008 and continues to the present day. The main subjects of these mobilisations are young people lacking sources of regular income and their core demands are secure employment and local development. It is argued that communal solidarities were key in compensating for the lack of occupational cohesion among the protesters.
Evaluating indicators of human well-being for ecosystem-based management
Authors: Breslow Sara Jo , Allen Margaret , Holstein Danielle , Sojka Brit , Barnea Raz , Basurto Xavier , Carothers Courtney , Charnley Susan , Coulthard Sarah , Dolšak Nives , Donatuto Jamie , García-Quijano Carlos , Hicks Christina C. , Levine Arielle , Mascia Michael B. , Norman Karma , Poe Melissa , Satterfield Terre , St. Martin Kevin , Levin Phillip S. 
Published: December 2017

ABSTRACT

Introduction:
Interrelated social and ecological challenges demand an understanding of how environmental change and management decisions affect human well-being. This paper outlines a framework for measuring human well-being for ecosystem-based management (EBM). We present a prototype that can be adapted and developed for various scales and contexts. Scientists and managers use indicators to assess status and trends in integrated ecosystem assessments (IEAs). To improve the social science rigor and success of EBM, we developed a systematic and transparent approach for evaluating indicators of human well-being for an IEA.

Methods:
Our process is based on a comprehensive conceptualization of human well-being, a scalable analysis of management priorities, and a set of indicator screening criteria tailored to the needs of EBM. We tested our approach by evaluating more than 2000 existing social indicators related to ocean and coastal management of the US West Coast. We focused on two foundational attributes of human well-being: resource access and self-determination.

Outcomes and Discussion:
Our results suggest that existing indicators and data are limited in their ability to reflect linkages between environmental change and human well-being, and extremely limited in their ability to assess social equity and justice. We reveal a critical need for new social indicators tailored to answer environmental questions and new data that are disaggregated by social variables to measure equity. In both, we stress the importance of collaborating with the people whose well-being is to be assessed.

Conclusion:
Our framework is designed to encourage governments and communities to carefully assess the complex tradeoffs inherent in environmental decision-making.
Final report, on-going key comparison BIPM.QM-K1, ozone at ambient level, comparison with NMISA, June 2017
Authors: Viallon Joële , Idrees Faraz , Moussay Philippe , Wielgosz Robert , Ntsasa Napo G , Tshilongo James , Mphaphuli Gumani E , Norris James E , Hodges Joseph T 
Published: December 2017

As part of the on-going key comparison BIPM.QM-K1, a comparison has been performed between the ozone national standard of South Africa maintained by the National Metrology Institute of South Africa (NMISA) and the common reference standard of the key comparison, maintained by the Bureau International des Poids et Mesures (BIPM), via a transfer standard maintained by the National Institute of Standards and Technology (NIST). The instruments have been compared over a nominal ozone amount-of-substance fraction range of 0 nmol/mol to 500 nmol/mol.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCQM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
PRAPI: post-transcriptional regulation analysis pipeline for Iso-Seq
Authors: Gao Yubang , Wang Huiyuan , Zhang Hangxiao , Wang Yongsheng , Chen Jinfeng , Gu Lianfeng 
Published: December 2017

Abstract

Summary
The single-molecule real-time (SMRT) isoform sequencing (Iso-Seq) based on Pacific Bioscience (PacBio) platform has received increasing attention for its ability to explore full-length isoforms. Thus, comprehensive tools for Iso-Seq bioinformatics analysis are extremely useful. Here, we present a one-stop solution for Iso-Seq analysis, called PRAPI to analyze alternative transcription initiation (ATI), alternative splicing (AS), alternative cleavage and polyadenylation (APA), natural antisense transcripts (NAT), and circular RNAs (circRNAs) comprehensively. PRAPI is capable of combining Iso-Seq full-length isoforms with short read data, such as RNA-Seq or polyadenylation site sequencing (PAS-seq) for differential expression analysis of NAT, AS, APA and circRNAs. Furthermore, PRAPI can annotate new genes and correct mis-annotated genes when gene annotation is available. Finally, PRAPI generates high-quality vector graphics to visualize and highlight the Iso-Seq results.

Availability and implementation
The Dockerfile of PRAPI is available at http://www.bioinfor.org/tool/PRAPI.
A functional CNVR_3425.1 damping lincRNA FENDRR increases lifetime risk of lung cancer and COPD in Chinese
Authors: Yang Lei , Wu Di , Chen Jinbin , Chen Jiansong , Qiu Fuman , Li Yinyan , Liu Li , Cao Yi , Yang Binyao , Zhou Yifeng , Lu Jiachun 
Published: December 2017

AbstractGenomic imbalance referring to somatic variation in chromosome copies represents the most frequent event in tumorigenesis. Germline copy number variations (gCNVs) overlapping regions of genomic imbalance harbor similar structural characteristics and thus influence tumor susceptibility. We aimed to test effects of such gCNVs on the risk of lung cancer and chronic obstructive pulmonary disease (COPD). Genomic imbalance of lung cancer was determined by the array comparative genomic hybridization (aCGH), and common gCNVs at these imbalance regions were genotyped in lung cancer-based and COPD-based retrospective studies. Functional assays were conducted to assess function of promising CNVs. A total of 115 genomic imbalances were discovered occurring at a frequency of more than 25%. The CNVR_3425.1, overlapping the chr16q24.1 with genomic imbalance, was significantly associated with increased risks of lung cancer (OR = 1.76; 95% CI = 1.46–2.11) and COPD (OR = 1.98; 95% CI = 1.57–2.51). The increase copy of CNVR_3425.1 forms a new additional truncated FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) sequences comparing the gene promoter and perturbs the transcriptional factors (TFs) binding to the original FENDRR promoter and further downregulates FENDRR, a long intergenic non-coding RNA (lincRNA) that functions to inhibit lung cancer by affecting expressions of an abundant number of genes, including the tumor suppressor FOXF1. FENDRR can upregulate FOXF1 by competitively binding to miR-424. The TFs early growth response 1 (EGR1) and transcription factor AP-2 alpha (TFAP2A) were further found to involve the CNVR_3425.1-mediated FENDRR dysregulation. These findings suggested the CNVR_3425.1 to be a possibly predictive biomarker for the risk of lung cancer and COPD, and targeted molecular therapy pertaining to FENDRR upregulation may be a valuable pathway to fight two diseases.
On the Neural and Mechanistic Bases of Self-Control
Authors: Turner Brandon M , Rodriguez Christian A , Liu Qingfang , Molloy M Fiona , Hoogendijk Marjolein , McClure Samuel M 
Published: December 2017

Abstract
Intertemporal choice requires a dynamic interaction between valuation and deliberation processes. While evidence identifying candidate brain areas for each of these processes is well established, the precise mechanistic role carried out by each brain region is still debated. In this article, we present a computational model that clarifies the unique contribution of frontoparietal cortex regions to intertemporal decision making. The model we develop samples reward and delay information stochastically on a moment-by-moment basis. As preference for the choice alternatives evolves, dynamic inhibitory processes are executed by way of asymmetric lateral inhibition. We find that it is these lateral inhibition processes that best explain the contribution of frontoparietal regions to intertemporal decision making exhibited in our data.
Dualized trust: risk, social trust and the welfare state
Authors: Kevins Anthony 
Published: December 2017

Abstract
This article examines how labour market vulnerability and social policy interact to shape generalized trust. Drawing insights from the literature on dualization, I suggest that: (1) labour market outsiders will have lower levels of generalized trust due to their increased risk exposure; and (2) active labour market policies, by conditioning labour market vulnerability, can reduce the impact of outsiderness on trust. Leveraging within-country cleavages between insiders and outsiders therefore allows us to assess one possible mechanism behind the welfare state’s generation of trust, while at the same time holding cultural context and broader trust levels constant. Analysis of data from the 2008–2014 waves of the European Social Survey then provides evidence of the impact of outsiderness on trust and the ability of social policy to moderate that effect. The investigation thus sheds light on both an additional consequence of dualization and a mechanism linking the welfare state to generalized trust.
Between Shell Shock and PTSD? ‘Accident Neurosis’ and Its Sequelae in Post-War Britain
Authors: Ross Ryan 
Published: December 2017

Summary
This article focuses on the concept of ‘accident neurosis’, popularised by neurologist Henry Miller in studies published in 1961. It aims to realise two goals. First, it introduces Miller’s concept of accident neurosis to the broader history of trauma—to a field, that is, more preoccupied with military traumata and clear-cut psychiatric aetiologies. Secondly, I use Miller’s studies, and the considerable legacy they created, to reflect on how historians of trauma construct historical narratives, asking whether there is sufficient appreciation of the ways in which events seem to leak into or retroactively animate one another.
Association Between Partial Pressure of Arterial Carbon Dioxide and Survival to Hospital Discharge Among Patients Diagnosed With Sepsis in the Emergency Department
Authors: Roberts Brian W. , Mohr Nicholas M. , Ablordeppey Enyo , Drewry Anne M. , Ferguson Ian T. , Trzeciak Stephen , Kollef Marin H. , Fuller Brian M. 
Published: December 2017

Objective:
The objective of this study was to test the association between the partial pressure of arterial carbon dioxide and survival to hospital discharge among mechanically ventilated patients diagnosed with sepsis in the emergency department.

Design:
Retrospective cohort study of a single center trial registry.

Setting:
Academic medical center.

Patients:
Mechanically ventilated emergency department patients. Inclusion criteria: age 18 years and older, diagnosed with sepsis in the emergency department, and mechanical ventilation initiated in the emergency department.

Interventions:
Arterial blood gases obtained after initiation of mechanical ventilation were analyzed. The primary outcome was survival to hospital discharge. We tested the association between partial pressure of arterial carbon dioxide and survival using multivariable logistic regression adjusting for potential confounders. Sensitivity analyses, including propensity score matching were also performed.

Measurements and Main Results:
Six hundred subjects were included, and 429 (72%) survived to hospital discharge. The median (interquartile range) partial pressure of arterial carbon dioxide was 42 (34–53) mm Hg for the entire cohort and 44 (35–57) and 39 (31–45) mm Hg among survivors and nonsurvivors, respectively (p < 0.0001 Wilcox rank-sum test). On multivariable analysis, a 1 mm Hg rise in partial pressure of arterial carbon dioxide was associated with a 3% increase in odds of survival (adjusted odds ratio, 1.03; 95% CI, 1.01–1.04) after adjusting for tidal volume and other potential confounders. These results remained significant on all sensitivity analyses.

Conclusion:
In this sample of mechanically ventilated sepsis patients, we found an association between increasing levels of partial pressure of arterial carbon dioxide and survival to hospital discharge. These findings justify future studies to determine the optimal target partial pressure of arterial carbon dioxide range for mechanically ventilated sepsis patients.
Cardiac Arrest and Mortality Related to Intubation Procedure in Critically Ill Adult Patients: A Multicenter Cohort Study
Authors: De Jong Audrey , Rolle Amélie , Molinari Nicolas , Paugam-Burtz Catherine , Constantin Jean-Michel , Lefrant Jean-Yves , Asehnoune Karim , Jung Boris , Futier Emmanuel , Chanques Gérald , Azoulay Elie , Jaber Samir 
Published: December 2017

Objectives:
To determine the prevalence of and risk factors for cardiac arrest during intubation in ICU, as well as the association of ICU intubation–related cardiac arrest with 28-day mortality.

Design:
Retrospective analysis of prospectively collected data.

Setting:
Sixty-four French ICUs.

Patients:
Critically ill patients requiring intubation in the ICU.

Interventions:
None.

Measurements and Main Results:
During the 1,847 intubation procedures included, 49 cardiac arrests (2.7%) occurred, including 14 without return of spontaneous circulation (28.6%) and 35 with return of spontaneous circulation (71.4%). In multivariate analysis, the main predictors of intubation-related cardiac arrest were arterial hypotension (systolic blood pressure < 90 mm Hg) prior to intubation (odds ratio = 3.406 [1.797–6.454]; p = 0.0002), hypoxemia prior to intubation (odds ratio = 3.991 [2.101–7.583]; p < 0.0001), absence of preoxygenation (odds ratio = 3.584 [1.287–9.985]; p = 0.0146), overweight/obesity (body mass index > 25 kg/m2; odds ratio = 2.005 [1.017–3.951]; p = 0.0445), and age more than 75 years old (odds ratio = 2.251 [1.080–4.678]; p = 0.0297). Overall 28-day mortality rate was 31.2% (577/1,847) and was significantly higher in patients who experienced intubation-related cardiac arrest than in noncardiac arrest patients (73.5% vs 30.1%; p < 0.001). After multivariate analysis, intubation-related cardiac arrest was an independent risk factor for 28-day mortality (hazard ratio = 3.9 [2.4–6.3]; p < 0.0001).

Conclusions:
ICU intubation–related cardiac arrest occurs in one of 40 procedures with high immediate and 28-day mortality. We identified five independent risk factors for cardiac arrest, three of which are modifiable, possibly to decrease intubation-related cardiac arrest prevalence and 28-day ICU mortality.