bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfiltered red‐purple pitaya concentrate: A promising multifunctional food‐derived colorant
Authors: de Sousa Silva Fernanda Tayla , da Rocha Viana José Diogo , Gomes da Silva Maria de Fátima , Silvestre da Silva Gisele , Florindo Guedes Maria Izabel , de Lima Rebouças Emanuela , Apolinário da Silva Ana Paula , Coutinho Marnielle Rodrigues , Wlisses da Silva Antônio , Rodrigues de Souza Arthur Claudio , Zocolo Guilherme Juliao , Herbster Moura Carlos Farley , Dionísio Ana Paula 
Published: September 2024

AbstractRed pitaya fruit has become a source of natural colorant, because it is rich in betalains, a pigment that imparts a red‐purple color that interests the food and cosmetics industries. This fruit also possesses high nutritional value, with a range of bioactive compounds known to confer potential health benefits and prevent chronic diseases, such as diabetes, which makes it useful for use as pharmaceutical agents and dietary supplements. In order to improve its technological and biological effects, a concentration will be required. Thus, the microfiltration, followed by vacuum concentration, can be an interesting strategy for this purpose. This study aimed to explore tangential microfiltration to produce microfiltered material, which is an important step to obtain the microfiltered red‐purple pitaya concentrate. Therefore, physicochemical and chemical characterization (including 1H NMR analysis) and biological properties (toxicity and diabetes) of this concentrate were assessed, using adult zebrafish as a model. The results show that microfiltration was carried out efficiently, with an average consumption of 95.75 ± 3.13 and 74.12 ± 3.58 kW h m−3, varying according to the material used (“unpeeled pitaya pulp” or “pitaya pulp with peel,” respectively). The in vivo tests indicated non‐toxicity and hypoglycemic effect of the concentrate, since the blood glucose levels were significantly lower in the zebrafish groups treated with this concentrate in comparison with that of control group. Thus, this study suggests the potential of microfiltered red‐purple pitaya concentrate as a promising multifunctional food‐derived colorant, exhibiting beneficial biological effects far beyond its attractive color.Practical ApplicationHylocereus polyrhizus (F.A.C. Weber) Britton & Rose has attracted attention as a potential source of natural colorants because of its red‐purple skin and flesh color. In addition, this fruit has a range of bioactive compounds, which make it a valuable resource for providing potential health benefits and preventing chronic diseases such as diabetes. In this paper, the microfiltered red‐purple pitaya concentrate showed beneficial biological effects far beyond its attractive color. Thus, this product can be considered a promising multifunctional food‐derived colorant to use in the food, pharmaceutical, or cosmetics industries.
North American considerations, strategies, and practices in reducing the sodium content in processed foods
Authors: Trumbo Paula R. , Glass Kathleen A. , Lee Soo‐Yeun , Moshfegh Alanna , Welling Paul A. , Zecca Patricia 
Published: September 2024

AbstractMost Americans exceed the recommended limit for sodium in their diet, a risk factor for hypertension and cardiovascular disease. Efforts have been made by the food industry and government agencies to reduce the sodium content in foods and encourage the consumption of lower sodium diets. Such efforts, however, are not successful in improving public health when consumers do not accept and consume lower sodium foods. This review article provides an overview of the strategies that have been used by the US food industry to reduce and replace sodium in consumer packaged goods, as well as future sodium reduction strategies and approaches for replacing sodium with potassium salts. Challenges in consumer acceptance regarding the reduction of sodium in foods are also discussed. Because of the widespread consumption of numerous sodium‐containing consumer packaged goods, implementing future strategies in various aspects of salt reduction and potassium replacement in foods should have a profound impact on the health of Americans.Practical ApplicationNew information is provided herein as it discusses the most current and collective perspectives of major food industry successes and challenges, as well as government strategies to decrease sodium intake. The information provided also addresses future strategies for reducing sodium content in foods, increasing potassium intake, and consumer acceptance of lower sodium foods.
Antifungal effect of cinnamon essential oil against Penicillium oxalicum on rice noodles
Authors: Liu Qun , Xiong Xiaodi , Lin Hua , Zhang Lixiang , Chen Naizhong , Liu Xing , Liu Tao 
Published: September 2024

AbstractPlant essential oils have been extensively investigated for their application in food industry due to their broad antimicrobial spectrum and safety. However, rare studies investigated their application in decontaminating rice noodles from fungal contamination. In this study, the cinnamon essential oil was screened out among 12 species of plant essential oils, and its antifungal activity against Penicillium oxalicum isolated from rice noodles was investigated. Our study revealed that cinnamon essential oil inhibited the spore germination in a concentration‐dependent manner, and a dosage of 0.025% (v/v) could entirely disable the spore germination. The disruption of the fungal plasma membrane was evidenced by the change of plasma membrane permeability and the leakage of cellular components. The cinnamon essential oil in vapor phase (0.00625% [v/v]) could totally inhibit the growth of fungi inoculated on rice noodles. In addition to the potential application in inactivating fungi germination on rice noodles, this study also demonstrated the feasibility of cinnamon essential as an environmental disinfectant. This study is the first report that cinnamon essential oil has been studied for decontaminating rice noodles from fungal contamination with P. oxalicum, which not only broadens the application field of plant essential oil but also provides an alternative approach for rice noodle preservation.
Financial constraints and sustainability in bioeconomy firms
Authors: Miranda‐García Marta , Segovia‐Vargas María‐Jesús 
Published: September 2024

AbstractIn the current scenario, sustainability has become vitally important. This paper focuses on bioeconomy as it links the economic systems and sustainable development, promoting innovative and environmentally friendly solutions. The bioeconomy firms need financial resources that play a critical role in their ordinary activities and in the activities that contribute to sustainability. The relationship between firms' ESG (environmental, social and governance) factors and their financing decisions has received little attention. Therefore, the objective of this article was to analyse the relationship between financial constraints and ESG performance focusing on bioeconomy firms. To carry out the analyses we have used 227 European bioeconomy firms developing three machine learning models. The main findings highlight the importance of the profitability (return on equity—ROE and return on assets—ROA) and the indebtedness in characterising firms' constraints, and the impact of non‐disclosure of ESG results. The study emphasises the economic importance of ESG practices in enhancing companies' financial conditions and access to capital, by using their corporate strategy and management: non‐disclosure of ESG information is related to an increase in funding constraints for listed bio companies. Thus, improving both economic and ESG performance can enhance access to capital, guiding business decisions.
miR‐30c‐5p inhibits esophageal squamous cell carcinoma progression by repressing the PI3K/AKT signaling pathway
Authors: Shi Haochun , Pan Binyang , Liang Jiaqi , Cai Benjie , Wu Gujie , Bian Yunyi , Shan Guangyao , Ren Shencheng , Huang Yiwei , Guo Weigang 
Published: September 2024

AbstractBackgroundEsophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors, with high incidence and poor prognosis. Revealing mechanisms of ESCC progression and developing new therapeutic targets remains crucial. The aim of this study was to elucidate the molecular mechanism of miR‐30c‐5p in regulating the malignant progression of ESCC.MethodsTCGA, GEO, and other datasets were used to analyze the differential expression of miR‐30c‐5p in ESCC and adjacent tissues, and its impact on prognosis. Then the effects of miR‐30c‐5p on the proliferation, migration, and invasion of TE‐1 and Eca9706 cells were investigated through proliferation experiments, transwell and wounding healing assays. The regulatory mechanism of miR‐30c‐5p on the PI3K/AKT signaling pathway and its interaction in cancer progression were investigated through Western blots, dual‐luciferase reporter assay, and rescue experiments.ResultsmiR‐30c‐5p was significantly downregulated in ESCC tissue and represented a poor prognosis. miR‐30c‐5p mimic significantly inhibited the proliferation, migration, and invasion ability of ESCC, while miR‐30c‐5p inhibitor significantly promoted tumor cell progression. Through bioinformatic analysis and experimental results, miR‐30c‐5p interacted directly with PIK3CA mRNA and inhibited subsequent signaling pathway activation. PIK3CA activator could eliminate the inhibitory effects of miR‐30c‐5p mimic on the progression of ESCC, while PIK3CA inhibitors could rescue the promoting effect of miR‐30c‐5p inhibitor group cells.ConclusionsIn summary, we found that miR‐30c‐5p inhibited the proliferation, invasion and migration of ESCC by inhibiting PI3K/AKT signaling pathway for the first time, and this study is expected to provide a novel insight and potential therapeutic target for managing ESCC.
Bank audit committee financial expertise and timely loan loss recognition
Authors: Choi Diana 
Published: September 2024

AbstractThis study investigates the effects of audit committee financial expertise on the timeliness of banks' loan loss provisions. I employ two regulatory shocks that mandated audit committee expertise—the Federal Deposit Insurance Corporation Improvement Act in 1991 (FDICIA) and a modified listing standard for NYSE and NASDAQ firms in 1999—as quasi‐exogenous settings to investigate the effects of audit committee financial expertise on the timeliness of loan loss provisioning. Using a difference‐in‐differences research design, I find that the timeliness of loan loss provisions increases with audit committee financial expertise both for the FDICIA treatment group, which had larger banks than the control group, and for the NYSE and NASDAQ exchange treatment group, which had smaller banks than the control group. Further, I find that the results are stronger for banks that have lower regulatory scrutiny, are audited by Big 4 auditors, and do not have staggered boards. Finally, I find that audit committee financial expertise decreases discretionary loan loss provisions and financial restatements. Overall, these findings suggest the importance of audit committee financial expertise in loan‐related matters, which is particularly relevant in the context of the recent Current Expected Credit Losses implementation.
A new materialist (re)configuring of sexuality, age and the discourse of ‘childhood innocence’
Authors: Ingram Toni , Allen Louisa 
Published: September 2024

AbstractThis article explores the potential of feminist new materialisms for rethinking enduring debates that cohere around children, sexuality, age and ‘childhood innocence’. A new materialist ontology of sexuality and Karen Barad's concept of spacetimemattering are employed to conceptualise sexuality as an emergent becoming of relational material‐discursive forces. Within this paradigm, mobilisation of arguments about ‘sexual innocence and readiness’ become a matter of entanglement of contingent ‘things’, ‘spaces’ and ‘ideas’, that includes young people's own sexual knowledge. We consider how this reorientation shifts the contours, debates and possibilities of sexuality education beyond restrictive ‘age‐appropriate’ narratives.
You Shall Not Pass: The Pacific Oxygen Minimum Zone Creates a Boundary to Shortfin Mako Shark Distribution in the Eastern North Pacific Ocean
Authors: Byrne Michael E. , Dewar Heidi , Vaudo Jeremy J. , Wetherbee Bradley M. , Shivji Mahmood S. 
Published: September 2024

ABSTRACTAimShoaling of large oxygen minimum zones (OMZs) that form along eastern margins of the world's oceans can reduce habitat availability for some pelagic fishes. Our aim was to test the hypothesis that habitat compression caused by shoaling of the Pacific OMZ in tropical regions creates a boundary to the southern distribution of shortfin mako sharks (Isurus oxyrinchus) in the Eastern North Pacific Ocean.LocationEastern North Pacific and Western North Atlantic oceans.MethodsWe compared environmental conditions between areas used by satellite‐tagged mako sharks in the Eastern North Pacific, encompassing the world's largest OMZ, to those used in the Western North Atlantic where no OMZ is present. In the Pacific we quantified the effects of temperature and dissolved oxygen (DO) on depth use and tested if sharks spent less time in areas with strong habitat compression over the OMZ than expected by chance.ResultsThe southern distribution of sharks in the Pacific corresponded with the apex of OMZ shoaling in the North Equatorial Current. Sharks in the Atlantic occupied areas with warm surface temperatures (≥ 26°C) more often than the Pacific, and waters with these temperatures in the Atlantic had greater DO at depth. Sharks in the Pacific reduced time near the surface in warm temperatures and consistently avoided depths with low DO and spent less time in areas with strong habitat compression than expected by chance.Main ConclusionsThe combination of warm surface temperatures and shoaling of the OMZ creates a soft boundary to mako shark movements in the Eastern North Pacific Ocean. The expected expansion of OMZs due to climate change could have considerable impact on future distribution of mako sharks and other pelagic fish. As such, development of species distribution models to predict the effects of climate change on pelagic fish distributions should incorporate oxygen availability.
Automating insulin delivery through pump and continuous glucose monitoring connectivity: Maximizing opportunities to improve outcomes
Authors: Anandhakrishnan Ananthi , Hussain Sufyan 
Published: September 2024

AbstractThe development of automated insulin delivery (AID) systems, which connect continuous glucose monitoring (CGM) systems with algorithmic insulin delivery from an insulin pump (continuous subcutaneous insulin infusion, [CSII]), has led to improved glycaemia and quality of life benefits in those with insulin‐treated diabetes. This review summarizes the benefits gained by the connectivity between insulin pumps and CGM devices. It details the technical requirements and advances that have enabled this, and highlights the clinical and user benefits of such systems. Clinical trials and real‐world outcomes from the use of AID systems in people with type 1 diabetes (T1D) will be the focus of this article; outcomes in people with type 2 diabetes (T2D) and other diabetes subtypes will also be discussed. We also detail the limitations of current technological approaches for connectivity between insulin pumps and CGM devices. While recognizing the barriers, we discuss opportunities for the future.
Technical Quality of Root Fillings Performed by Undergraduate Dental Students in Single‐Canal Teeth: A 10‐Year Retrospective Study
Authors: Bezerra Vinicius Grangeiro Leite , Ferreira André de Lima , Fernandes Viton Dyrk Guimarães , Teixeira‐da‐Silva Douglas , Paranhos Luiz Renato , Matos Felipe de Souza 
Published: September 2024

ABSTRACTObjectiveThis study assessed the radiographic technical quality of root fillings in single‐canal teeth performed over a decade (June 2013 to June 2023) by undergraduate dental students of the Federal University of Campina Grande.MethodsAll teeth underwent chemomechanical preparation using Gates‐Glidden drills and hand instrumentation with stainless steel files up to 1 mm short of the root apex. Apical expansion was performed with up to two or three instruments above the initial anatomical apical diameter. The canal was filled in the absence of signs and symptoms of infection using gutta‐percha cones and Sealer 26 or MTA Fillapex. A post‐filling radiograph was routinely taken to assess the quality of root filling and coronal restoration. An experienced researcher trained and calibrated an examiner to evaluate post‐operative periapical radiographs considering root‐filling length, lateral adaptation and taper using ImageJ 1.52q software. Root filling was satisfactory when reaching acceptable classifications for the three parameters. The chi‐squared test compared tooth type, dental arch and pulpal diagnosis at a 5% significance level.ResultsThe study assessed 124 canals, showing 90 (72.6%) satisfactory root fillings. The sub‐analysis of individual parameters demonstrated that 105 (84.7%) root fillings had acceptable length, 113 (91.1%) adapted well to lateral canal walls, and 109 (87.9%) had proper taper. Most cases occurred in maxillary teeth (n = 99), pulp necrosis was the most frequent pulpal diagnosis (n = 89), and root‐filling quality showed no association with tooth type, dental arch or pulpal diagnosis.ConclusionThe technical quality of root fillings in single‐canal teeth treated by dental students was predominantly satisfactory.
Population Genomics of the Blue Shark, Prionace glauca, Reveals Different Populations in the Mediterranean Sea and the Northeast Atlantic
Authors: Leone Agostino , Arnaud‐Haond Sophie , Babbucci Massimiliano , Bargelloni Luca , Coscia Ilaria , Damalas Dimitrios , Delord Chrystelle , Franch Rafaella , Garibaldi Fulvio , Macias David , Mariani Stefano , Martinsohn Jann , Megalofonou Persefoni , Micarelli Primo , Nikolic Natacha , Prodöhl Paulo A. , Sperone Emilio , Stagioni Marco , Zanzi Antonella , Cariani Alessia , Tinti Fausto 
Published: September 2024

ABSTRACTPopulations of marine top predators have been sharply declining during the past decades, and one‐third of chondrichthyans are currently threatened with extinction. Sustainable management measures and conservation plans of large pelagic sharks require knowledge on population genetic differentiation and demographic connectivity. Here, we present the case of the Mediterranean blue shark (Prionace glauca, L. 1758), commonly found as bycatch in longline fisheries and classified by the IUCN as critically endangered. The management of this species suffers from a scarcity of data about population structure and connectivity within the Mediterranean Sea and between this basin and the adjacent Northeast Atlantic. Here, we assessed the genetic diversity and spatial structure of blue shark from different areas of the Mediterranean Sea and the Northeast Atlantic through genome scan analyses. Pairwise genetic differentiation estimates (FST) on 203 specimens genotyped at 14,713 ddRAD‐derived SNPs revealed subtle, yet significant, genetic differences within the Mediterranean sampling locations, and between the Mediterranean Sea and the Northeast Atlantic Ocean. Genetic differentiation suggests some degree of demographic independence between the Western and Eastern Mediterranean blue shark populations. Furthermore, results show limited genetic connectivity between the Mediterranean and the Atlantic basins, supporting the hypothesis of two distinct populations of blue shark separated by the Strait of Gibraltar. Although reproductive interactions may be limited, the faint genetic signal of differentiation suggests a recent common history between these units. Therefore, Mediterranean blue sharks may function akin to a metapopulation relying upon local demographic processes and connectivity dynamics, whereby the limited contemporary gene flow replenishment from the Atlantic may interplay with currently poorly regulated commercial catches and large‐scale ecosystem changes. Altogether, these results emphasise the need for revising management delineations applied to these critically endangered sharks.
An efficient branch‐and‐bound algorithm to optimize a function over a nondominated set
Authors: Zerfa Lamia , Chergui Mohamed El‐Amine 
Published: September 2024

AbstractThis study introduces an algorithm based on the branch‐and‐bound approach for optimizing a main function over the nondominated set of a multiobjective integer programming (MOIP) problem. Initially, is optimized within the feasible solution set of the MOIP. A new efficiency test combining Benson's test with is then developed using an auxiliary optimization program. This program provides both an efficient solution and a lower bound for . Moreover, this solution is the best one for when compared to its alternative solutions for MOIP. Subsequently, efficient cuts are incorporated into the criteria space to eliminate dominated points. Furthermore, the algorithm is tailored to handle scenarios where the objective involves optimizing a linear combination of multiobjective programming criteria over the nondominated set. The study concludes by showcasing the superior performance of the proposed two algorithms through comparison with existing approaches on well‐known problem instances from the literature.
Problems in screening for gestational diabetes mellitus by measurement of casual blood glucose levels at 24–28 gestational weeks
Authors: Tomimoto Masako , Tanimura Kenji , Masuko Naohisa , Uchida Akiko , Imafuku Hitomi , Deguchi Masashi , Yamamoto Akane , Hirota Yushi , Ogawa Wataru , Terai Yoshito 
Published: September 2024

ABSTRACTAims/IntroductionThis study aimed to evaluate the problems in screening for gestational diabetes mellitus (GDM) by casual blood glucose (CBG) measurements at 24–28 gestational weeks.Materials and MethodsOverall, 763 pregnant women who underwent the 50‐g glucose challenge test (GCT) at 24–28 gestational weeks were enrolled. The preload blood glucose (0‐h BG) level of 50‐g GCT was considered as CBG.ResultsA total of 240 women with BG levels at 1‐h after loading (1‐h BG) on 50‐g GCT ≥140 mg/dL underwent the 75‐g oral glucose tolerance test, and 98 (40.8%) were diagnosed with GDM. Of the 99 women with GDM, 71 (71.7%) had 0‐h BG on 50‐g GCT <100 mg/dL.ConclusionsThis study, where pregnant women underwent both CBG and 50‐g GCT simultaneously, showed that when CBG at 24–28 gestational weeks ≥100 mg/dL alone was used for screening GDM, many pregnant women with GDM were overlooked.