bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology Investigation of stroke among Mongolian and Han population aged over 45 in Inner Mongolia
Authors: Zhang Chunyu , Lan Tian , Zhe Yan , Hu Baolige , Zhang Guohua , He Juan , Wang Zhiguang , Jiang Mingfang , Hu Riletemuer 
Published: April 2017

AbstractTo discuss the status of epidemiology of stroke in the Mongolian and Han population aged over 45 years and to understand the treatment and prevention of stroke. Data collected on stroke populations aged over 45 years in the six areas in Inner Mongolia were analyzed by using stratified multi-stage cluster sampling. The prevalence rate of stroke in patients aged over 45 years in Inner Mongolia was 4.62%. The stroke prevalence rate increased with age in both males and females, the Han and Mongolian populations, and was higher in males than in females in Inner Mongolia. The prevalence rate of stroke in the Mongolian population was higher than in the Han population. The incidence rate of stroke in patients aged over 45 years in Inner Mongolia was 0.28%, of which the rate of relapsed ischemic stroke was 23.29%. The proportion of ischemic stroke in the stroke patients was higher than hemorrhagic stroke. The prevalence and incidence rates of stroke in patients aged over 45 years in Inner Mongolia were high. The prevalence rate of stroke in both the Han population and the Mongolian population increased with age. Ischemic stroke was the major form of stroke.
Genome-wide identification of membrane-bound fatty acid desaturase genes in Gossypium hirsutum and their expressions during abiotic stress
Authors: Feng Jiyu , Dong Yating , Liu Wei , He Qiuling , Daud M. K. , Chen Jinhong , Zhu Shuijin 
Published: April 2017

AbstractMembrane-bound fatty acid desaturases (FADs) are of great importance and play multiple roles in plant growth and development. In the present study, 39 full-length FAD genes, based on database searches, were identified in tetraploid upland cotton (Gossypium hirsutumL.) and were phylogenetically clustered into four subfamilies. Genomic localization revealed that 34 genes were mapped on 22 chromosomes, and five genes were positioned on the scaffold sequences. The FAD genes ofG. hirsutumin the same subfamily had similar gene structures. The structures of paralogous genes were considerably conserved in exons number and introns length. It was suggested that the FAD gene families inG. hirsutummight be duplicated mainly by segmental duplication. Moreover, the FAD genes were differentially expressed in differentG. hirsutumtissues in response to different levels of salt and cold stresses, as determined by qRT-PCR analysis. The identification and functional analysis of FAD genes inG. hirsutummay provide more candidate genes for genetic modification.
Indium gallium nitride-based ultraviolet, blue, and green light-emitting diodes functionalized with shallow periodic hole patterns
Authors: Jeong Hyun , Salas-Montiel Rafael , Lerondel Gilles , Jeong Mun Seok 
Published: April 2017

AbstractIn this study, we investigated the improvement in the light output power of indium gallium nitride (InGaN)-based ultraviolet (UV), blue, and green light-emitting diodes (LEDs) by fabricating shallow periodic hole patterns (PHPs) on the LED surface through laser interference lithography and inductively coupled plasma etching. Noticeably, different enhancements were observed in the light output powers of the UV, blue, and green LEDs with negligible changes in the electrical properties in the light output power versus current and current versus voltage curves. In addition, confocal scanning electroluminescence microscopy is employed to verify the correlation between the enhancement in the light output power of the LEDs with PHPs and carrier localization of InGaN/GaN multiple quantum wells. Light propagation through the PHPs on the UV, blue, and green LEDs is simulated using a three-dimensional finite-difference time-domain method to confirm the experimental results. Finally, we suggest optimal conditions of PHPs for improving the light output power of InGaN LEDs based on the experimental and theoretical results.
Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy
Authors: Liu Zhigang , Ren Bo , Wang Yihui , Zou Chen , Qiao Qinglian , Diao Zhijun , Mi Yashi , Zhu Di , Liu Xuebo 
Published: April 2017

AbstractSesamol, a nutritional phenolic antioxidant compound enriched in sesame seeds, has been shown to have potential anticancer activities. This study aims at characterizing the antitumor efficacy of sesamol and unveiling the importance of mitochondria in sesamol-induced effects using a human hepatocellular carcinoma cell line, HepG2 cells. Results of this study showed that sesamol treatment suppressed colony formation, elicited S phase arrest during cell cycle progression, and induced both intrinsic and extrinsic apoptotic pathway in vitro with a dose-dependent manner. Furthermore, sesamol treatment elicited mitochondrial dysfunction by inducing a loss of mitochondrial membrane potential. Impaired mitochondria and accumulated H2O2 production resulted in disturbance of redox-sensitive signaling including Akt and MAPKs pathways. Mitochondrial biogenesis was inhibited as suggested by the decline in expression of mitochondrial complex I subunit ND1, and the upstream AMPK/PGC1α signals. Importantly, sesamol inhibited mitophagy and autophagy through impeding the PI3K Class III/Belin-1 pathway. Autophagy stimulator rapamycin reversed sesamol-induced apoptosis and mitochondrial respiration disorders. Moreover, it was also shown that sesamol has potent anti-hepatoma activity in a xenograft nude mice model. These data suggest that mitochondria play an essential role in sesamol-induced HepG2 cells death, and further research targeting mitochondria will provide more chemotherapeutic opportunities.
Quantification of bioluminescence from the surface to the deep sea demonstrates its predominance as an ecological trait
Authors: Martini Séverine , Haddock Steven H. D. 
Published: April 2017

AbstractThe capability of animals to emit light, called bioluminescence, is considered to be a major factor in ecological interactions. Because it occurs across diverse taxa, measurements of bioluminescence can be powerful to detect and quantify organisms in the ocean. In this study, 17 years of video observations were recorded by remotely operated vehicles during surveys off the California Coast, from the surface down to 3,900 m depth. More than 350,000 observations are classified for their bioluminescence capability based on literature descriptions. The organisms represented 553 phylogenetic concepts (species, genera or families, at the most precise taxonomic level defined from the images), distributed within 13 broader taxonomic categories. The importance of bioluminescent marine taxa is highlighted in the water column, as we showed that 76% of the observed individuals have bioluminescence capability. More than 97% of Cnidarians were bioluminescent, and 9 of the 13 taxonomic categories were found to be bioluminescent dominant. The percentage of bioluminescent animals is remarkably uniform over depth. Moreover, the proportion of bioluminescent and non-bioluminescent animals within taxonomic groups changes with depth for Ctenophora, Scyphozoa, Chaetognatha, and Crustacea. Given these results, bioluminescence has to be considered an important ecological trait from the surface to the deep-sea.
Efficacy of alirocumab according to background statin type and dose: pooled analysis of 8 ODYSSEY Phase 3 clinical trials
Authors: Catapano Alberico L. , Lee L. Veronica , Louie Michael J. , Thompson Desmond , Bergeron Jean , Krempf Michel 
Published: April 2017

AbstractLow-density lipoprotein cholesterol (LDL-C) reductions with the PCSK9 monoclonal antibody alirocumab may be affected by background statin dose due to increased PCSK9 levels with higher statin doses. Data from 8 Phase 3 trials conducted with background statin (n = 4629) were pooled by alirocumab dose (75 or 150 mg every 2 weeks) and control (placebo/ezetimibe), and analyzed by background statin type/dose. Overall, 58.4% received high-dose statins (atorvastatin 40–80 mg, rosuvastatin 20–40 mg, simvastatin 80 mg), 28.6% moderate-dose statins (atorvastatin 20–<40 mg, rosuvastatin 10–<20 mg, simvastatin 40–<80 mg), and 12.9% low-dose statins (atorvastatin <20 mg, rosuvastatin <10 mg, simvastatin <40 mg). Mean baseline PCSK9 levels were higher with high versus moderate and low statin doses (318.5 vs 280.6 ng/mL). Baseline LDL-C levels were similar across pools, regardless of statin intensity. No associations were observed between statin type/dose and LDL-C % change from baseline or % of patients achieving LDL-C goals at Week 24 for alirocumab versus control (interaction P-values non-significant). Incidence of adverse events was similar for alirocumab versus control, except for a higher rate of injection-site reactions with alirocumab. In summary, alirocumab provided consistent LDL-C reductions and was generally well tolerated independent of background statin type/dose.
Fibroblast growth factor 21, assisted by elevated glucose, activates paraventricular nucleus NUCB2/Nesfatin-1 neurons to produce satiety under fed states
Authors: Santoso Putra , Nakata Masanori , Shiizaki Kazuhiro , Boyang Zhang , Parmila Kumari , Otgon-Uul Zesemdorj , Hashimoto Koshi , Satoh Tetsurou , Mori Masatomo , Kuro-o Makoto , Yada Toshihiko 
Published: April 2017

AbstractFibroblast growth factor 21 (FGF21), liver-derived hormone, exerts diverse metabolic effects, being considered for clinical application to treat obesity and diabetes. However, its anorexigenic effect is debatable and whether it involves the central mechanism remains unclarified. Moreover, the neuron mediating FGF21’s anorexigenic effect and the systemic energy state supporting it are unclear. We explored the target neuron and fed/fasted state dependence of FGF21’s anorexigenic action. Intracerebroventricular (ICV) injection of FGF21 markedly suppressed food intake in fed mice with elevated blood glucose. FGF21 induced c-Fos expression preferentially in hypothalamic paraventricular nucleus (PVN), and increased mRNA expression selectively for nucleobindin 2/nesfatin-1 (NUCB2/Nesf-1). FGF21 at elevated glucose increased [Ca2+]i in PVN NUCB2/Nesf-1 neurons. FGF21 failed to suppress food intake in PVN-preferential Sim1-Nucb2-KO mice. These findings reveal that FGF21, assisted by elevated glucose, activates PVN NUCB2/Nesf-1 neurons to suppress feeding under fed states, serving as the glycemia-monitoring messenger of liver-hypothalamic network for integrative regulation of energy and glucose metabolism.
Light absorption engineering of a hybrid (Sn3S72−)n based semiconductor – from violet to red light absorption
Authors: Hvid Mathias Salomon , Lamagni Paolo , Lock Nina 
Published: April 2017

AbstractThe crystalline two-dimensional thiostannate Sn3S7(trenH)2 [tren = tris(2-aminoethyl)amine] consists of negatively charged (Sn3S72−)n polymeric sheets with trenH+ molecular species embedded in-between. The semiconducting compound is a violet light absorber with a band gap of 3.0 eV. In this study the compound was synthesized and functionalized by introducing the cationic dyes Methylene Blue (MB) or Safranin T (ST) into the crystal structure by ion exchange. Dye capacities up to approximately 45 mg/g were obtained, leading to major changes of the light absorption properties of the dye stained material. Light absorption was observed in the entire visible light region from red to violet, the red light absorption becoming more substantial with increasing dye content. The ion exchange reaction was followed in detail by variation of solvent, temperature and dye concentration. Time-resolved studies show that the ion exchange follows pseudo-second order kinetics and a Langmuir adsorption mechanism. The pristine and dye stained compounds were characterized by powder X-ray diffraction and scanning electron microscopy revealing that the honeycomb hexagonal pore structure of the host material was maintained by performing the ion exchange in the polar organic solvent acetonitrile, while reactions in water caused a break-down of the long-range ordered structure.
Localised residency and inter-annual fidelity to coastal foraging areas may place sea bass at risk to local depletion
Authors: Doyle Thomas K. , Haberlin Damien , Clohessy Jim , Bennison Ashley , Jessopp Mark 
Published: April 2017

AbstractFor many marine migratory fish, comparatively little is known about the movement of individuals rather than the population. Yet, such individual-based movement data is vitally important to understand variability in migratory strategies and fidelity to foraging locations. A case in point is the economically important European sea bass (Dicentrarchus labraxL.) that inhabits coastal waters during the summer months before migrating offshore to spawn and overwinter. Beyond this broad generalisation we have very limited information on the movements of individuals at coastal foraging grounds. We used acoustic telemetry to track the summer movements and seasonal migrations of individual sea bass in a large tidally and estuarine influenced coastal environment. We found that the vast majority of tagged sea bass displayed long-term residency (mean, 167 days) and inter-annual fidelity (93% return rate) to specific areas. We describe individual fish home ranges of 3 km or less, and while fish clearly had core resident areas, there was movement of fish between closely located receivers. The combination of inter-annual fidelity to localised foraging areas makes sea bass very susceptible to local depletion; however, the designation of protected areas for sea bass may go a long way to ensuring the sustainability of this species.
Homogenizing cellular tension by hepatocyte growth factor in expanding epithelial monolayer
Authors: Jang Hwanseok , Notbohm Jacob , Gweon Bomi , Cho Youngbin , Park Chan Young , Kee Sun-Ho , Fredberg Jeffrey J. , Shin Jennifer H. , Park Yongdoo 
Published: April 2017

AbstractHepatocyte growth factor (HGF) induces cell migration and scattering by mechanisms that are thought to tip a local balance of competing physical forces; cell-to-cell and cell-to-substrate forces. In this local process, HGF is known to attenuate local cadherin-dependent adhesion forces for cell-cell junction development and enhance local integrin-dependent contractile forces for pulling neighboring cells apart. Here we use an expanding island of confluent Madin-Darby canine kidney (MDCK) cells as a model system to quantify the collective cell migration. In the absence of HGF, cell trajectories are highly tortuous whereas in the presence of HGF, they become far less so, resembling free expansion of a gas. At the level of cell-to-cell junctions, HGF attenuates the linkage of stress fibers to cell-to-cell junctions with concomitant decrease in intercellular stress. At the level of cell-to-substrate junctions, HGF augments the linkage of stress fibers to cell-to-substrate junctions with no apparent effect on traction. Together, HGF induces both structural changes in the actin-bound junctional protein complex and physical forces spanning multicellular clusters, which further promotes the expansion of confluent cellular layer.
Comparison for Efficacy and Tolerability among Ten Drugs for Treatment of Parkinson’s Disease: A Network Meta-Analysis
Authors: Zhuo Chuanjun , Zhu Xiaodong , Jiang Ronghuan , Ji Feng , Su Zhonghua , Xue Rong , Zhou Yuying 
Published: April 2017

AbstractParkinson’s disease (PD) is a long term disorder affects the central nervous system and we aim to determine the relative efficacy of the current available drugs used in PD. Firstly, we performed a systematic review in current literature and eligible studies were retrieved from online databases, relevant data were extracted. Efficacy of these medications was assessed by different Unified Parkinson’s Disease Rating Scales (UPDRS). Mean difference (MD) and odds ratio (OR) were produced by pairwise or network meta-analysis (NMA). Finally, we performed a cluster analysis for the included medications with respect to their surface under the cumulative ranking curve (SUCRA). Pairwise meta-analysis suggests that selegiline had a higher ranking in UPDRS II, UPDRS III and UPDRS total than bromocriptine and levodopa. Selegiline was more tolerable than bromocriptine (OR = 0.62, CI: 0.39 to 0.98) and pramipexole was less tolerable than levodopa (OR = 1.43, CI = 1.00 to 2.04). Results of NMA indicate that patients with levodopa, pramipexole, ropinirole and selegiline exhibited a significantly improved UPDRS III than those with lazabemide. To sum up, levodopa, selegiline, ropinirole and rotigotine were recommended for PD patients as they appeared relatively high efficacy and tolerability.
Brillouin scattering-induced rogue waves in self-pulsing fiber lasers
Authors: Hanzard Pierre-Henry , Talbi Mohamed , Mallek Djouher , Kellou Abdelhamid , Leblond Hervé , Sanchez François , Godin Thomas , Hideur Ammar 
Published: April 2017

AbstractWe report the experimental observation of extreme instabilities in a self-pulsing fiber laser under the influence of stimulated Brillouin scattering (SBS). Specifically, we observe temporally localized structures with high intensities that can be referred to as rogue events through their statistical behaviour with highly-skewed intensity distributions. The emergence of these SBS-induced rogue waves is attributed to the interplay between laser operation and resonant Stokes orders. As this behaviour is not accounted for by existing models, we also present numerical simulations showing that such instabilities can be observed in chaotic laser operation. This study opens up new possibilities towards harnessing extreme events in highly-dissipative systems through adapted laser cavity configurations.
Effect of agomelatine on memory deficits and hippocampal gene expression induced by chronic social defeat stress in mice
Authors: Martin Vincent , Allaïli Najib , Euvrard Marine , Marday Tevrasamy , Riffaud Armance , Franc Bernard , Mocaër Elisabeth , Gabriel Cecilia , Fossati Philippe , Lehericy Stéphane , Lanfumey Laurence 
Published: April 2017

AbstractChronic stress is known to induce not only anxiety and depressive-like phenotypes in mice but also cognitive impairments, for which the action of classical antidepressant compounds remains unsatisfactory. In this context, we investigated the effects of chronic social defeat stress (CSDS) on anxiety-, social- and cognitive-related behaviors, as well as hippocampal Bdnf, synaptic plasticity markers (PSD-95, Synaptophysin, Spinophilin, Synapsin I and MAP-2), and epigenetic modifying enzymes (MYST2, HDAC2, HDAC6, MLL3, KDM5B, DNMT3B, GADD45B) gene expression in C57BL/6J mice. CSDS for 10 days provoked long-lasting anxious-like phenotype in the open field and episodic memory deficits in the novel object recognition test. While total Bdnf mRNA level was unchanged, Bdnf exon IV, MAP-2, HDAC2, HDAC6 and MLL3 gene expression was significantly decreased in the CSDS mouse hippocampus. In CSDS mice treated 3 weeks with 50 mg/kg/d agomelatine, an antidepressant with melatonergic receptor agonist and 5-HT2C receptor antagonist properties, the anxious-like phenotype was not reversed, but the treatment successfully prevented the cognitive impairments and hippocampal gene expression modifications. Altogether, these data evidenced that, in mice, agomelatine was effective in alleviating stress-induced altered cognitive functions, possibly through a mechanism involving BDNF signaling, synaptic plasticity and epigenetic remodeling.
Meissner effect measurement of single indium particle using a customized on-chip nano-scale superconducting quantum interference device system
Authors: Wu Long , Chen Lei , Wang Hao , Liu Xiaoyu , Wang Zhen 
Published: April 2017

AbstractAs many emergent phenomena of superconductivity appear on a smaller scale and at lower dimension, commercial magnetic property measurement systems (MPMSs) no longer provide the sensitivity necessary to study the Meissner effect of small superconductors. The nano-scale superconducting quantum interference device (nano-SQUID) is considered one of the most sensitive magnetic sensors for the magnetic characterization of mesoscopic or microscopic samples. Here, we develop a customized on-chip nano-SQUID measurement system based on a pulsed current biasing method. The noise performance of our system is approximately 4.6 × 10−17 emu/Hz1/2, representing an improvement of 9 orders of magnitude compared with that of a commercial MPMS (~10−8 emu/Hz1/2). Furthermore, we demonstrate the measurement of the Meissner effect of a single indium (In) particle (of 47 μm in diameter) using our on-chip nano-SQUID system. The system enables the observation of the prompt superconducting transition of the Meissner effect of a single In particle, thereby providing more accurate characterization of the critical field Hc and temperature Tc. In addition, the retrapping field Hre as a function of temperature T of single In particle shows disparate behavior from that of a large ensemble.
Lattice thermal conductivity of borophene from first principle calculation
Authors: Xiao Huaping , Cao Wei , Ouyang Tao , Guo Sumei , He Chaoyu , Zhong Jianxin 
Published: April 2017

AbstractThe phonon transport property is a foundation of understanding a material and predicting the potential application in mirco/nano devices. In this paper, the thermal transport property of borophene is investigated by combining first-principle calculations and phonon Boltzmann transport equation. At room temperature, the lattice thermal conductivity of borophene is found to be about 14.34 W/mK (error is about 3%), which is much smaller than that of graphene (about 3500 W/mK). The contributions from different phonon modes are qualified, and some phonon modes with high frequency abnormally play critical role on the thermal transport of borophene. This is quite different from the traditional understanding that thermal transport is usually largely contributed by the low frequency acoustic phonon modes for most of suspended 2D materials. Detailed analysis further reveals that the scattering between the out-of-plane flexural acoustic mode (FA) and other modes likes FA + FA/TA/LA/OP ↔ TA/LA/OP is the predominant phonon process channel. Finally the vibrational characteristic of some typical phonon modes and mean free path distribution of different phonon modes are also presented in this work. Our results shed light on the fundamental phonon transport properties of borophene, and foreshow the potential application for thermal management community.
Delineation of molecular pathway activities of the chronic antidepressant treatment response suggests important roles for glutamatergic and ubiquitin–proteasome systems
Authors: Park D I , Dournes C , Sillaber I , Ising M , Asara J M , Webhofer C , Filiou M D , Müller M B , Turck C W 
Published: April 2017

AbstractThe aim of this study was to identify molecular pathways related to antidepressant response. We administered paroxetine to the DBA/2J mice for 28 days. Following the treatment, the mice were grouped into responders or non-responders depending on the time they spent immobile in the forced swim test. Hippocampal metabolomics and proteomics analyses revealed that chronic paroxetine treatment affects glutamate-related metabolite and protein levels differentially in the two groups. We found significant differences in the expression of N-methyl-d-aspartate receptor and neuronal nitric oxide synthase proteins between the two groups, without any significant alterations in the respective transcript levels. In addition, we found that chronic paroxetine treatment altered the levels of proteins associated with the ubiquitin–proteasome system (UPS). The soluble guanylate cyclase-β1, proteasome subunit α type-2 and ubiquitination levels were also affected in peripheral blood mononuclear cells from antidepressant responder and non-responder patients suffering from major depressive disorder. We submit that the glutamatergic system and UPS have a crucial role in the antidepressant treatment response in both mice and humans.