bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Simple Method for Attenuation Correction in Local X-Band Radar Measurements Using C-Band Radar Data
Authors: Lengfeld Katharina , Clemens Marco , Merker Claire , Münster Hans , Ament Felix 
Published: September 2016

AbstractThis paper presents a novel, simple method to correct reflectivity measurements of weather radars that operate in attenuation-influenced frequency bands using observations from less attenuated radar systems. In recent years radar systems operating in the X-band frequency range have been developed to provide precipitation fields for areas of special interest in high temporal (≤1 min) and spatial (≤250 m) resolution in complement to nationwide radar networks. However, X-band radars are highly influenced by attenuation. C- and S-band radars typically have coarser resolution (250 m–1 km and 5 min) but are less affected by attenuation.Correcting for attenuation effects in simple (non-Doppler) single-polarized X-band radars remains challenging and is often dependent on restriction parameters, for example, those derived from mountain returns. Therefore, these algorithms are applicable only in limited areas. The method proposed here uses measurements from C-band radars and hence can be applied in all regions covered by nationwide C- (or S-) band radar networks. First, a single scan of X-band radar measurements is used exemplary to identify advantages and disadvantages of the novel algorithm compared to a standard single radar algorithm. The performance of the correction algorithms in different types of precipitation is examined in nine case studies. The proposed method provides very promising results for each type of precipitation. Additionally, it is evaluated in a 5-month comparison with Micro Rain Radar (MRR) observations. The bias between uncorrected X-band radar and MRR data is nearly eliminated by the attenuation correction algorithm, and the RMSE is reduced by 20% while the correlation of ~0.9 between both systems remains nearly constant.
Effectiveness of Depression–Suicidal Behaviour Gatekeeper Training among police officers in three European regions: Outcomes of the Optimising Suicide Prevention Programmes and Their Implementation in Europe (OSPI-Europe) study
Authors: Arensman Ella , Coffey Claire , Griffin Eve , Van Audenhove Chantal , Scheerder Gert , Gusmao Ricardo , Costa Susana , Larkin Celine , Koburger Nicole , Maxwell Margaret , Harris Fiona , Postuvan Vita , Hegerl Ulrich 
Published: September 2016

Background: Gatekeeper training for community facilitators, to identify and respond to those at risk of suicide, forms an important part of multi-level community-based suicide prevention programmes. Aims: This study examined the effects of gatekeeper training on attitudes, knowledge and confidence of police officers in dealing with persons at risk of suicide. Methods: A total of 828 police officers across three European regions participated in a 4-hour training programme which addressed the epidemiology of depression and suicidal behaviour, symptoms of depression, warning signs and risk factors associated with suicidal behaviour, motivating help-seeking behaviour, dealing with acute suicidal crisis and informing bereaved relatives. Participants completed internationally validated questionnaires assessing stigmatising attitudes, knowledge about depression and confidence in dealing with suicidal persons pre- and post-training. Results: There were significant differences among countries in terms of previous exposure to suicidal persons and extent of previous training. Post-training evaluation demonstrated significant improvements in stigmatising attitudes, knowledge and confidence in all three countries. Conclusion: The consistently positive effects of gatekeeper training of police officers across different regions support inclusion of this type of training as a fundamental part of multi-level community-based suicide prevention programmes and roll-out, nationally and internationally.
Convergent Validity, Concurrent Validity, and Diagnostic Accuracy of the interRAI Depression Rating Scale
Authors: Penny Katherine , Barron Alex , Higgins Ann-Marie , Gee Susan , Croucher Matthew , Cheung Gary 
Published: September 2016

Aims: Depression Rating Scale (DRS) is one of the clinical outcome measures of the International Resident Assessment Instrument (interRAI) assessment. The primary aim of this study is to investigate the diagnostic accuracy and concurrent validity of the 3-day assessment window version of the DRS. Methods: The performance of DRS was compared with a gold standard clinical diagnosis of depression in 92 patients (age ≥65) who had interRAI version 9.1 Home Care assessment completed within 30 days of discharge from psychogeriatric inpatient care or memory clinic assessment. Results: The DRS had poor diagnostic accuracy for depression diagnosis with an area under the curve of 0.68 (95% confidence interval [CI] = 0.57-0.77). The DRS score had a poor to moderate correlation with the Health of the Nation Outcome Scale 65+ depression item score ( rs = 0.30, 95% CI = 0.09-0.48, P = .006). Conclusion: This study and the existing literature raise concerns that the DRS is not an adequate measure of depression.
Person-Based Versus Generalized Impulsivity Disinhibition in Frontotemporal Dementia and Alzheimer Disease
Authors: Paholpak Pongsatorn , Carr Andrew R. , Barsuglia Joseph P. , Barrows Robin J. , Jimenez Elvira , Lee Grace J. , Mendez Mario F. 
Published: September 2016

Background: While much disinhibition in dementia results from generalized impulsivity, in behavioral variant frontotemporal dementia (bvFTD) disinhibition may also result from impaired social cognition. Objective: To deconstruct disinhibition and its neural correlates in bvFTD vs. early-onset Alzheimer’s disease (eAD). Methods: Caregivers of 16 bvFTD and 21 matched-eAD patients completed the Frontal Systems Behavior Scale disinhibition items. The disinhibition items were further categorized into (1) “person-based” subscale which predominantly associated with violating social propriety and personal boundary and (2) “generalized-impulsivity” subscale which included nonspecific impulsive acts. Subscale scores were correlated with grey matter volumes from tensor-based morphometry on magnetic resonance images. Results: In comparison to the eAD patients, the bvFTD patients developed greater person-based disinhibition ( P < 0.001) but comparable generalized impulsivity. Severity of person-based disinhibition significantly correlated with the left anterior superior temporal sulcus (STS), and generalized-impulsivity correlated with the right orbitofrontal cortex (OFC) and the left anterior temporal lobe (aTL). Conclusions: Person-based disinhibition was predominant in bvFTD and correlated with the left STS. In both dementia, violations of social propriety and personal boundaries involved fronto-parieto-temporal network of Theory of Mind, whereas nonspecific disinhibition involved the OFC and aTL.
An improved parallelism scheme for deterministic discrete ordinates transport
Authors: Deakin Tom , McIntosh-Smith Simon , Martineau Matt , Gaudin Wayne 
Published: September 2016

In this paper we demonstrate techniques for increasing the node-level parallelism of a deterministic discrete ordinates neutral particle transport algorithm on a structured mesh to exploit many-core technologies. Transport calculations form a large part of the computational workload of physical simulations and so good performance is vital for the simulations to complete in reasonable time. We will demonstrate our approach utilizing the SNAP mini-app, which gives a simplified implementation of the full transport algorithm but remains similar enough to the real algorithm to act as a useful proxy for research purposes. We present an OpenCL implementation of our improved algorithm which achieves a speedup of up to 2.5 × on a many-core GPGPU device compared to a state-of-the-art multi-core node for the transport sweep, and up to 4 × compared to the multi-core CPUs in the largest GPU enabled supercomputer; the first time this scale of speedup has been achieved for algorithms of this class. We then discuss ways to express our scheme in OpenMP 4.0 and demonstrate the performance on an Intel Knights Corner Xeon Phi compared to the original scheme.
High-resolution computed tomography evaluation of the bronchial lumen to vertebral body diameter and pulmonary artery to vertebral body diameter ratios in anesthetized ventilated normal cats
Authors: Lee-Fowler Tekla M , Cole Robert C , Dillon A Ray , Tillson D Michael , Garbarino Rachel , Barney Sharron 
Published: September 2016

Objectives Bronchial lumen to pulmonary artery diameter (BA) ratio has been utilized to investigate pulmonary pathology on high-resolution CT images. Diseases affecting both the bronchi and pulmonary arteries render the BA ratio less useful. The purpose of the study was to establish bronchial lumen diameter to vertebral body diameter (BV) and pulmonary artery diameter to vertebral body diameter (AV) ratios in normal cats. Methods Using high-resolution CT images, 16 sets of measurements (sixth thoracic vertebral body [mid-body], each lobar bronchi and companion pulmonary artery diameter) were acquired from young adult female cats and 41 sets from pubertal female cats. Results Young adult and pubertal cat BV ratios were not statistically different from each other in any lung lobe. Significant differences between individual lung lobe BV ratios were noted on combined age group analysis. Caudal lung lobe AV ratios were significantly different between young adult and pubertal cats. All other lung lobe AV ratios were not significantly different. Caudal lung lobe AV ratios were significantly different from all other lung lobes but not from each other in both the young adult and pubertal cats. Conclusions and relevance BV ratio reference intervals determined for individual lung lobes could be applied to both young adult and pubertal cats. Separate AV ratios for individual lung lobes would be required for young adult and pubertal cats. These ratios should allow more accurate evaluation of cats with concurrent bronchial and pulmonary arterial disease.
A Systematic Review of DNA Methylation and Preterm Birth in African American Women
Authors: Barcelona de Mendoza Veronica , Wright Michelle L. , Agaba Comfort , Prescott Laura , Desir Alexandra , Crusto Cindy A. , Sun Yan V. , Taylor Jacquelyn Y. 
Published: September 2016

Background: The causes of many cases of preterm birth (PTB) remain enigmatic. Increased understanding of how epigenetic factors are associated with health outcomes has resulted in studies examining DNA methylation (DNAm) as a contributing factor to PTB. However, few studies on PTB and DNAm have included African American women, the group with the highest rate of PTB. Methods: The objective of this review was to systematically analyze the existing studies on DNAm and PTB among African American women. Results: Studies ( N = 10) were limited by small sample size, cross-sectional study designs, inconsistent methodologies for epigenomic analysis, and evaluation of different tissue types across studies. African Americans comprised less than half of the sample in 50% of the studies reviewed. Despite these limitations, there is evidence for an association between DNAm patterns and PTB. Conclusions: Future research on DNAm patterns and PTB should use longitudinal study designs, repeated DNAm testing, and a clinically relevant definition of PTB and should include large samples of high-risk African American women to better understand the mechanisms for PTB in this population.
The design and conduct of Keep It Off: An online randomized trial of financial incentives for weight-loss maintenance
Authors: Shaw Pamela A , Yancy William S , Wesby Lisa , Ulrich Victoria , Troxel Andrea B , Huffman David , Foster Gary D , Volpp Kevin 
Published: September 2016

Background Obesity continues to be a serious public health challenge. Rates are increasing worldwide, with nearly 70% of the US adults overweight or obese, leading to increased clinical and economic burden. While successful approaches for achieving weight loss have been identified, techniques for long-term maintenance of initial weight loss have largely been unsuccessful. Financial incentive interventions have been shown in several settings to be successful in motivating participants to adopt healthy behaviors. Purpose Keep It Off is a three-arm randomized controlled trial that compares the efficacy of a lottery-based incentive, traditional direct payment incentive, and control of daily feedback without any incentive for weight-loss maintenance. This design allows comparison of a traditional direct payment incentive with one based on behavioral economic principles that consider the underlying psychology of decision-making. Methods Participants were randomized in a 2:1 ratio for each active arm relative to control, with a targeted 188 participants in total. Eligible participants were those aged 30–80 who lost at least 11 lb (5 kg) during the first 4 months of participation in Weight Watchers, a national weight-loss program, with whom we partnered. The interventions lasted 6 months (Phase I); participants were followed for an additional 6 months without intervention (Phase II). The primary outcome is weight change from baseline to the end of Phase I, with the change at the end of Phase II a key secondary endpoint. Keep It Off is a pragmatic trial that recruited, consented, enrolled, and followed patients electronically. Participants were provided a wireless weight scale that electronically transmitted daily self-monitored weights. Weights were verified every 3 months at a Weight Watchers center local to the participant and electronically transmitted. Results Using the study web-based platform, we integrated recruitment, enrollment, and follow-up procedures into a digital platform that required little staff effort to implement and manage. We randomized 191 participants in less than 1 year. We describe the design of Keep It Off and implementation of enrollment. Lessons Learned We demonstrated that our pragmatic design was successful in rapid accrual of participants in a trial of interventions to maintain weight loss. Limitations Despite the nationwide reach of Weight Watchers, the generalizability of study findings may be limited by the characteristics of its members. The interventions under study are appropriate for settings where an entity, such as an employer or health insurance company, could offer them as a benefit. Conclusions Keep It Off was implemented and conducted with minimal staff effort. This study has the potential to identify a practical and effective weight-loss maintenance strategy.
A retrospective case-control study evaluating thiazide-induced hyponatraemia-related hospitalisation among older Singaporeans
Authors: Abdul Naseer Jishana Farhad , Chen Li Li , Gui Huey Sywu , Ong Kheng Yong , Cheen Mcvin Hua Heng , Mamun Kaysar 
Published: September 2016

Introduction: Thiazide diuretics are recommended as first-line therapy for hypertension in older adults. However, thiazides are also associated with hyponatraemia-related hospitalisations in older patients. This study aims to determine the predictors of hospitalisation due to thiazides usage in older adults. Methods: This is a retrospective matched case-control study. Patients aged ⩾65 admitted due to adverse drug reactions based on International Classification of Diseases, Ninth Revision (ICD9) codes from the period of 1 June to 31 December 2011 in Singapore General Hospital were extracted. Patients with the ICD9 code E944.3 Saluretics causing adverse effects in therapeutic use and who experienced thiazide-induced hyponatraemia were identified. Controls were identified from a pool of patients from outpatient clinics who were prescribed thiazide during the study period. Each case was matched to four controls based on gender and race. Patients’ demographics, length of stay, and cost of hospital admission were obtained. Results: In total, 19 cases with thiazide-induced hyponatraemia were matched with 76 controls. Cases were older than control (78.8±6.1 vs. 75.6±7.0, p=0.052), with the majority being females (84.2%) and Chinese (94.7%). The mean length of stay was 4 (±3) days; the mean cost of stay was SGD 1118 (±898). Serum potassium levels and concurrent use of beta-blockers were identified as unadjusted possible predictors for hospitalisation due to thiazide-induced hyponatraemia. Conclusion: Potential predictors of hospitalisation due to thiazide-induced hyponatraemia include low potassium levels and concurrent use of beta-blockers. Identification of predictors is crucial to guide safe and effective prescribing of thiazides in older patients.
Discussion of several contractions by Jachymski’s approach
Authors: Suzuki Tomonari 
Published: September 2016

AbstractWe discuss several contractions of integral type by using Jachymski’s approach. We give alternative proofs of recent generalizations of the Banach contraction principle due to Ri (Indag. Math. 27:85-93, 2016) and Wardowski (Fixed Point Theory Appl. 2012:94, 2012).
The effect of adenoid hypertrophy on maxillofacial development: An objective photographic analysis
Authors: Koca Cigdem Fırat , Erdem Tamer , Bayındır Tuba 
Published: September 2016

Background Deformity in the dental arc and facial skeleton by adenoid hypertrophy due to chronic mouth breathing is a well-known process. Most of the related studies have been based on cephalometric analyses. The aim of this study is to detect the presence of skeletal deformities on the soft tissue by analyzing distances and angles on photographs. Methods Ninety-seven children having between 25 and 100 % of adenoids, ages 4–12 years (48 boys, 49 girls), and 90 cases having 0–25 % adenoid tissue, ages 4–12 years (54 boys, 36 girls), were studied by clinical history, physical examination (including endoscopy), and standardized clinical photographs. The children and parents were asked if any of the following were present in the children: snoring, sleep apnea, daytime sleepiness, poor school performance, mouth breathing during sleep, smoking parents, and restlessness during sleep. Results The assessment of linear and angular measurements on the clinical photographs showed, in the group having thicker adenoids compared with controls, a statistically significant increase in the distance between nasion and tip and nasion and subnasale and in the angle between Frankfort horizontal plane-gnathion-angulus mandible; there was also a statistically significant decrease in the distance between endocanthion and exocanthion and the angles between tragion-angulus mandible and gnathion and between nasion-angulus mandible and gnathion. Conclusions The analyses showed a significant increase in the anterior face height and increase in the angle between Frankfort horizontal plane-gnathion-angulus mandible and a retropositioned and posterior-rotated mandible due to thicker adenoids. Trial registration 2010/140 Date: 04 January 2010.
Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012
Authors: Pang Herbert H. , Wang Xiaofei , Stinchcombe Thomas E. , Wong Melisa L. , Cheng Perry , Ganti Apar Kishor , Sargent Daniel J. , Zhang Ying , Hu Chen , Mandrekar Sumithra J. , Redman Mary W. , Manola Judith B. , Schilsky Richard L. , Cohen Harvey J. , Bradley Jeffrey D. , Adjei Alex A. , Gandara David , Ramalingam Suresh S. , Vokes Everett E. 
Published: September 2016

Purpose Under-representation of elderly, women, and racial/ethnic minority patients with cancer in clinical trials is of national concern. The goal of this study was to characterize enrollment trends and disparities by age, sex, and race/ethnicity in lung cancer trials. Methods We analyzed data for 23,006 National Cancer Institute cooperative group lung cancer trial participants and 578,476 patients with lung cancer from the SEER registry from 1990 to 2012. The enrollment disparity difference (EDD) and enrollment disparity ratio (EDR) were calculated on the basis of the proportion of each subgroup in the trial population and the US lung cancer population. Annual percentage changes (APCs) in the subgroup proportions in each population were compared over time. Results Enrollment disparity for patients ≥ 70 years of age with non–small-cell lung cancer improved from 1990 to 2012 (test of parallelism, P = .020), with a remaining EDD of 0.22 (95% CI, 0.19 to 0.25) and EDR of 1.65 (95% CI, 1.51 to 1.82) in 2010 to 2012. No improvement was seen for elderly patients with small-cell lung cancer (SCLC), with an APC of 0.20 ( P = .714) among trial participants, despite a rising proportion of elderly patients with SCLC in the US population (APC, 0.32; P = .020). Enrollment disparity for women with lung cancer improved overall, with the gap closing by 2012 (EDD, 0.03 [95% CI, 0.00 to 0.06]; EDR, 1.07 [95% CI, 1.00 to 1.16]). Enrollment disparities persisted without significant improvement for elderly women, blacks, Asians/Pacific Islanders, and Hispanics. Conclusion Under-representation in lung cancer trials improved significantly from 1990 to 2012 for elderly patients with non–small-cell lung cancer and for women, but ongoing efforts to improve the enrollment of elderly patients with SCLC and minorities are needed. Our study highlights the importance of addressing enrollment disparities by demographic and disease subgroups to better target under-represented groups of patients with lung cancer.
Modified Staging Classification for Pancreatic Neuroendocrine Tumors on the Basis of the American Joint Committee on Cancer and European Neuroendocrine Tumor Society Systems
Authors: Luo Guopei , Javed Ammar , Strosberg Jonathan R. , Jin Kaizhou , Zhang Yu , Liu Chen , Xu Jin , Soares Kevin , Weiss Matthew J. , Zheng Lei , Wolfgang Christopher L. , Cives Mauro , Wong Joyce , Wang Wei , Sun Jian , Shao Chenghao , Wang Wei , Tan Huangying , Li Jie , Ni Quanxing , Shen Lin , Chen Minhu , He Jin , Chen Jie , Yu Xianjun 
Published: September 2016

Purpose The European Neuroendocrine Tumor Society (ENETS) and the American Joint Committee on Cancer (AJCC) staging classifications are two widely used systems in managing pancreatic neuroendocrine tumors. However, there is no universally accepted system. Methods An analysis was performed to evaluate the application of the ENETS and AJCC staging classifications using the SEER registry (N = 2,529 patients) and a multicentric series (N = 1,143 patients). A modified system was proposed based on analysis of the two existing classifications. The modified system was then validated. Results The proportion of patients with AJCC stage III disease was extremely low for both the SEER series (2.2%) and the multicentric series (2.1%). For the ENETS staging system, patients with stage I disease had a similar prognosis to patients with stage IIA disease, and patients with stage IIIB disease had a lower hazard ratio for death than did patients with stage IIIA disease. We modified the ENETS staging classification by maintaining the ENETS T, N, and M definitions and adopting the AJCC staging definitions. The proportion of patients with stage III disease using the modified ENETS (mENETS) system was higher than that of the AJCC system in both the SEER series (8.9% v 2.2%) and the multicentric series (11.6% v 2.1%). In addition, the hazard ratio of death for patients with stage III disease was higher than that for patients with stage IIB disease. Moreover, statistical significance and proportional distribution were observed in the mENETS staging classification. Conclusion An mENETS staging classification is more suitable for pancreatic neuroendocrine tumors than either the AJCC or ENETS systems and can be adopted in clinical practice.