bluuebunny/crossref_metadata_2025_split huggingface dataset:
Congeneric and Robust Adhesive Epidermal Patch for Anti‐Interference Physiological Signal Recognition
Authors: Gan Dingli , Wang Qian , Zhang Xinyi , Qu Xinyu , Sun Hanjun , Cui Ying , Wang Wenjun , Qu Lulu , Dong Xiaochen 
Published: September 2024

AbstractEpidermal patches utilized for the transduction of biopotentials and biomechanical signals are pivotal in wearable health monitoring. However, the shortcomings, such as inferior conformal ability, deficient adhesion, and motion artifacts, severely impede the bioelectrodes from perceiving stable and superior‐quality physiological signals. Herein, a polymer epidermal patch possessing a spontaneous Janus structure is facilely prepared through itaconic acylhydrazine (IAH) induced gradient polymerization. The solubility discrepancy of the monomers in IAH authorized the Janus structure with distinct adhesion properties on each side. Moreover, the hydrogen bond network constructed by IAH confers the polymer with a high degree of skin compliance, enabling dynamic and stable mechanical properties to withstand complex monitoring environments. By integrating skin‐like softness (Young's modulus ≈0.16 MPa), robust adhesion (35 kPa), and high signal‐to‐noise ratio (32 dB), this epidermal patch displays exceptional elasticity within the physiological activity spectrum, provides swift electrical and mechanical self‐recovery capabilities, and resists interference in dynamic signal monitoring (deformation, compression, humidity, etc.). By demonstrating multifaceted applications for Electrocardiogram recording under diverse disturbances, the epidermal patch profiles a promising noninvasive, enduring wearable bioelectronic interface with immunity to interference.
Boosting Zinc‐Ion Storage Capability in Longitudinally Aligned MXene Arrays with Microchannel Architecture
Authors: Lin Congjian , Zhang Yingmeng , Lieu Wei Ying , Xu Yongtai , Li Dong‐Sheng , Sliva Arlindo , Yang Hui Ying 
Published: September 2024

AbstractFlexible Zn2+ ion hybrid capacitors (ZHCs) will play a crucial role in developing next‐generation wearable products, which demand portability, durability, and environmental adaptability. To further meet these requirements, Ti3C2Tx MXene with exceptional conductivity and robust mechanical properties can be utilized as cathodes, except for challenges such as the dense stacking of Ti3C2Tx nanosheets. In this study, a novel MXene cathode architecture has been developed with the facilitation of an ice template, which creates longitudinally aligned Ti3C2Tx arrays with microchannels. The introduction of hydrochloric acid to the Ti3C2Tx slurry induces a crumpled morphology, increasing active sites and enhancing ion transport with expanded interlayer spacing. Interestingly, experimental results and COMSOL simulations verify that the cathode structure also has effective impacts on the Zn anode with a weakened ion concentration gradient and suppressed dendrite formation. Consequently, the ZHCs exhibit enhanced electrochemical performance with excellent rate performance and long‐term cycling stability (enduring over 50 000 cycles at 5 A g−1) and further deliver a reliable low‐temperature operation by applying an anti‐freezing electrolyte. Moreover, flexible ZHCs assembled with gel electrolytes demonstrate excellent flexibility, improved rate performance, and mechanical stability, making them well‐suited for flexible electronics that power flexible LED panels.
Development of Neural Cells and Spontaneous Neural Activities in Engineered Brain‐Like Constructs for Transplantation
Authors: Gai Ke , Yang Mengliu , Chen Wei , Hu Chenyujun , Luo Xiao , Smith Austin , Xu Caizhe , Zhang Hefeng , Li Xiang , Shi Wei , Sun Wei , Lin Feng , Song Yu 
Published: September 2024

AbstractStem cell transplantation has demonstrated efficacy in treating neurological disorders by generating functional cells and secreting beneficial factors. However, challenges remain for current cell suspension injection therapy, including uncontrollable cell distribution, the potential for tumor formation, and limited ability to treat spatial defects. Therefore, implants with programmable cell development, tailored 3D structure, and functionalized biomaterials have the potential to both control cell distribution and reduce or heal spatial defects. Here, a biomimetic material system comprising gelatin, alginate, and fibrinogen has been developed for neural progenitor cell constructs using 3D printing. The resulting constructs exhibit excellent formability, stability, and developmental functions in vitro, as well as biocompatibility and integration into the hippocampus in vivo. The controllability, reproducibility, and material composition of the constructs show potential for use in personalized stem cell‐based therapies for defective neurological disorders, neural development research, disease modeling, and organoid‐derived intelligent systems.
Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS‐induced Depressive‐Like Behaviors
Authors: Ju Minzi , Zhang Zhongkun , Gao Feng , Chen Gang , Zhao Sibo , Wang Dan , Wang Huijuan , Jia Yanpeng , Shen Ling , Yuan Yonggui , Yao Honghong 
Published: September 2024

AbstractMajor depressive disorder (MDD) is a prevalent mental disorder that significantly impacts social and psychological function, but no effective medication is currently available. Circular RNAs (circRNAs) have been reported to participate in the pathogenesis of MDD which are envisioned as promising therapeutic targets. However, nonviral‐based delivery strategies targeting circRNA against MDD are not thoroughly investigated. Here, it is identified that circATF7IP is significantly upregulated in plasma samples and positively correlated with 24‐Hamilton Depression Scale (HAMD‐24) scores of MDD patients. Synergistic amine lipid nanoparticles (SALNPs) are designed to deliver siRNA targeting circATF7IP (si‐circATF7IP) into the hippocampus brain region by intranasal administration. Intranasal delivery of SALNP‐si‐circATF7IP successfully alleviated the depressive‐like behaviors in the LPS‐induced mouse depression model via decreasing CD11b+CD45dim microglia population and pro‐inflammatory cytokine productions (TNF‐α and IL‐6). These results indicate that the level of circATF7IP positively correlates with MDD pathogenesis, and SALNP delivery of si‐circATF7IP via intranasal administration is an effective strategy to ameliorate LPS‐induced depressive‐like behaviors.
Immuno‐Rolling Circle Amplification (Immuno‐RCA): Biosensing Strategies, Practical Applications, and Future Perspectives
Authors: Zhang Limei , Bai Hao , Zou Jie , Zhang Chuyan , Zhuang Weihua , Hu Jie , Yao Yongchao , Hu Wenchuang (Walter) 
Published: September 2024

AbstractIn the rapidly evolving field of life sciences and biomedicine, detecting low‐abundance biomolecules, and ultraweak biosignals presents significant challenges. This has spurred a rapid development of analytical techniques aiming for increased sensitivity and specificity. These advancements, including signal amplification strategies and the integration of biorecognition events, mark a transformative era in bioanalytical precision and accuracy. A prominent method among these innovations is immuno‐rolling circle amplification (immuno‐RCA) technology, which effectively combines immunoassays with signal amplification via RCA. This process starts when a targeted biomolecule, such as a protein or cell, binds to an immobilized antibody or probe on a substrate. The introduction of a circular DNA template triggers RCA, leading to exponential amplification and significantly enhanced signal intensity, thus the target molecule is detectable and quantifiable even at the single‐molecule level. This review provides an overview of the biosensing strategy and extensive practical applications of immuno‐RCA in detecting biomarkers. Furthermore, it scrutinizes the limitations inherent to these sensors and sets forth expectations for their future trajectory. This review serves as a valuable reference for advancing immuno‐RCA in various domains, such as diagnostics, biomarker discovery, and molecular imaging.
Enhanced Colorimetric Detection of Volatile Organic Compounds Using a Dye‐Incorporated Photonic Crystal‐Based Sensor Array
Authors: Nah So Hee , Kim Jong Bin , Chui Hiu Ning Tiffany , Suh Yeonjoon , Yang Shu 
Published: September 2024

AbstractChemoresponsive dyes offer the potential to selectively detect volatile organic compounds (VOCs) unique to certain disease states. Among different VOC sensing techniques, colorimetric sensing offers the advantage of facile recognition. However, it is often challenging to discern the color changes by the naked eye. Here, highly sensitive colorimetric VOC sensor arrays from dye‐incorporated colloidal photonic crystals (dye‐cPhCs) are reported. cPhCs are scalably fabricated on a 4‐inch wafer by spin‐coating of silica nanoparticles (NPs) dispersed in a photo‐cross‐linkable monomer, where the gradient shear flow along the film thickness creates densely‐packed square arrays of NPs in the top layers, whereas the bulk is quasi‐amorphous with larger periodicities. The broadened reflection peak allows for augmented dye absorption originating from the overlap between the photonic bandgap edge of the cPhC and the dye absorption peak, leading to a more noticeable color change upon exposure to VOCs. The sensor array generates distinct color difference maps for acetaldehyde, acetone, and acetic acid, respectively, without any data amplification. The limit of detection for acetaldehyde, acetone, and acetic acid is 1, 0.1, and 0.02 ppm, respectively. Moreover, VOC can be diagonalized by visually intuitive pattern recognition, and principal component analysis at reduced dimensionality is demonstrated.
Photorheologic Silicone Composites with Adaptive Properties by Utilizing Light‐Degradable Organosilica Nanoparticles as Fillers
Authors: Klodwig Florian , Finck Laura , Ehlert Nina , Behrens Peter , Menzel Henning , Polarz Sebastian 
Published: September 2024

AbstractImplementing inorganic filler particles is a powerful method for improving the mechanical properties of polymer composites. The physical properties are determined by the interaction of the filler with the polymer. Thus, factors like the surface‐to‐volume ratio and surface modification are important. Besides the strategies of influencing these physical properties by a prior modification of the filler, this approach applies a post‐treatment of the composite. The present publication focuses on bringing stimuli‐responsive properties to a composite material by changing the chemical composition and structure of the filler particles. Instead of creating a responsive polymer, the concept is to use photo‐degradable organosilica nanoparticles that can change the mechanical properties of a polymer/filler composite after it has been prepared. After the synthesis of nitrobenzyl ether containing organosilica nanoparticles and the investigation of the photochemical processes, the preparation of the composites with silicones is described. Vinyl groups are attached to the surfaces to secure a homogeneous distribution of the filler particles inside the polymer matrix. After light‐induced decomposition, the mechanical properties are investigated. Other than expected, the material becomes stiffer, which is explained by an increase in the surface area of the silica particles, accompanied by the emergence of hydroxy groups that interact with the polysiloxane.
Ruthenium (II)‐Catalysed Regioselective C6 Alkylation of Indoles with Maleimides
Authors: Jadhav Pankaj , Dawande Sudam 
Published: September 2024

AbstractRuthenium (II)‐catalysed regioselective C6 alkylation of indole‐7‐carboxamides with maleimide has been described. Electronically diverse maleimides reacted with various indoles to furnish corresponding C6 substituted succinimide derivatives of indoles with 46–89% yields. The reaction shows functional group tolerance. The synthetic utility of the reaction has been demonstrated through the conversion of the obtained product to the corresponding hexahydropyridazinyl derivative. We also studied the kinetics of the reaction through intermolecular competitive experiments with electronically distinct indole‐7‐carboxamides.
Tri‐Layer Heterostructure Channel of a‐IGZO/a‐ITZO/a‐IGZO Toward Enhancement of Transport and Reliability in Amorphous Oxide Semiconductor Thin Film Transistors
Authors: Hu Ke , Guo Zean , Wang Jiawei , Lu Congyan , Wang Mingliang , Wang Tianyuan , Liao Fuxi , Yang Guanhua , Lu Nianduan , Li Ling 
Published: September 2024

AbstractThin film transistors (TFTs) based on amorphous oxide semiconductors (AOS) are promising candidates for panel displays. However, the trade‐off between mobility and reliability in AOS‐TFTs hinders their further applications in next‐generation display techniques and newly developed logic and memory circuits. Here, a structural strategy is proposed for the mobility‐reliability trade‐off, via a triple‐layer channel containing a Ga‐free high‐mobility layer (amorphous InSnZnO, a‐ITZO) sandwiched by two Ga‐rich layers (amorphous InGaZnO, a‐IGZO) with higher reliability. Gate‐induced carrier accumulation is verified mainly being energetically confined within the high mobility a‐ITZO layer, at the newly defined a‐ITZO/a‐IGZO interface. Compared to single layer a‐ITZO‐TFTs, triple‐channel a‐IGZO/a‐ITZO/a‐IGZO TFTs (GTG‐TFTs) exhibit outstanding stability and electrical transport performances, with suppressed positive/negative‐bias‐stress voltage shifts from 1/0.3 to 0.1/0.004 V, enhanced field effect mobility from ≈40 to 56 cm2V−1s−1, and optimized sub‐threshold swing down to 80 mV dec−1. Further numerical simulations and charge transport characterizations, including magnetotransport and gate‐induced Hall effect, indicate that charge transport in tri‐layer structure is less affected by energetic disorders present at gate insulator interfaces.
Achieving High‐Voltage Stability in Li‐Rich Ni‐Rich Oxides with Local W/Ni(Li) Superstructure
Authors: Gao Xu , Li Biao , Rousse Gwenaëlle , Morozov Anatolii V. , Deschamps Michaël , Elkaïm Erik , Zhang Leiting , Kummer Kurt , Abakumov Artem M. , Tarascon Jean‐Marie 
Published: September 2024

AbstractCreating high‐energy‐density cathodes is crucial for building next‐generation lithium‐ion batteries. However, materials exploration along two main directions, namely Li‐rich or Ni‐rich oxides, has encountered bottlenecks. To get rid of the impasse, here a “Li‐rich Ni‐rich” route is consolidated by designing a new family of Li1+yNi(3‐5y)/3W2y/3O2 oxides with high‐voltage cycling stability up to 4.5 V and high capacities over 230 mAh g−1. It is discovered that W6+ is largely incorporated into the LiNiO2 lattice, forming W/Ni(Li) inverse honeycomb‐ordered nano‐domains. These Li‐rich domains enable reversible anionic redox, clearly demonstrated by X‐ray absorption spectroscopy, resonant inelastic X‐ray scattering, transmission electron microscopy, and nuclear magnetic resonance, which is linked to improved electrochemical performance. Furthermore, the incorporation of W6+ into the lattice proves to be the key to generating electrochemically active Li‐rich domains irrespective of Li stoichiometry given that a similar local structure is found in W‐substituted non‐Li‐rich oxides. This therefore implies the underestimated role of high‐valence cations in tuning the structure and electrochemistry of Ni‐rich oxides. These results underline the necessity of a Li‐rich composition in the request for reversible high capacity, reinforcing the promise of a “Li‐rich Ni‐rich” avenue for developing advanced cathodes.
Agronomic responses and economic returns from wheat–canola rotation under Humalite and urea applications
Authors: Nallanthighal Sumedha Vaishnavi , Enesi Rebecca Oiza , Thilakarathna Malinda S. , Gorim Linda Yuya 
Published: September 2024

AbstractHumalite is a humic acid‐rich biostimulant known for its ability to improve plant agronomic parameters and increase crop nitrogen use. Limited field research exists on Humalite effect, its application rate, and its interaction with urea, especially at reduced rates on grain agronomic parameters. Therefore, a field study was conducted from 2021 to 2023 at three Alberta sites—Battle River Research Group (BRRG), Gateway Research Organization (GRO), and St. Albert Research Station (St. Albert), in a split‐plot design with four replications, three urea levels (i.e., recommended, half‐recommend, and zero urea) combined with five Humalite rates (0, 56 (or 112), 224, 448, and 896 kg ha−1). In 2021, the highest wheat yields were observed at half urea rates plus 224 kg ha−1 at BRRG (35% yield increase), GRO (8.4% yield increase), and St. Albert (33.5% yield increase). In 2022, canola yields were unaffected by Humalite application rates. In 2023, wheat yields from half‐recommended and recommended urea rates plots outperformed zero urea plots across all sites, regardless of Humalite rates. The highest wheat grain protein content values were observed at 224–448 kg ha−1 of Humalite plus half‐recommended or recommended urea rate. Depending on the site, the highest net revenue resulted from half urea rates plus Humalite at application rates between 112 and 448 kg ha−1 in wheat, that is, optimal Humalite rate for increased profitability. Therefore, the incorporation of biostimulants such as Humalite can reduce urea use and contribute to the sustainability of wheat cropping systems.
Precision management influences productivity and nutrients availability in dryland cropping system
Authors: Mikha Maysoon M. , Mankin Kyle R. , Khan Shahbaz B. , Barnard David M. 
Published: September 2024

AbstractPrecision management (PM) aims to reduce inputs while increasing land productivity and economical return and enhancing cropping system resiliency to climate change. This study evaluated how climate (precipitation) and management influenced yields and soil nutrients in a dryland agricultural system. We compared an “aspirational” (ASP) system (no‐till, 4‐year rotation of winter wheat [Triticum aestivum L.], corn [Zea mays L.], proso millet [Panicum miliaceum L.], and fallow/flex) to a traditional “business‐as‐usual” (BAU) system (reduced tillage, 2‐year rotation of winter wheat and fallow: W–F). Phases of each rotation were included yearly throughout the study period (2018–2022) with three replications. The ASP system incorporated PM by dividing each ASP field into three zones (high‐, medium‐, and low‐PM) according to prior yield and topography. Nitrogen was applied at high, medium, or low application rates within those zones. Under favorable precipitation, wheat, corn, and millet yields responded to PM treatments, with yields increasing proportional to N addition. Years with low in‐season precipitation had a significant reduction in wheat and corn yields (2020 and 2022) and complete millet yield failures (2020 and 2021). Low soil organic matter accumulation (0.1%–0.5%) and a reduction in soil macro‐ and micronutrient status suggested that soil nutrient additions are needed to prevent soil‐nutrient degradation. The ASP treatment added a third crop every 4 years and did so without significantly decreasing wheat yield following fallow. The ASP management shows promise as an alternative to BAU in the Great Plains dryland production region.
Tracking anthropometric dimensions and grip strength among children, adolescents and adults in an indigenous community of southern Mexico: 1968–1978–2000
Authors: Little Bertis B. , Peña Reyes Maria Eugenia , Malina Robert M. 
Published: September 2024

AbstractPurposeTo track body size and proportions, arm dimensions and grip strength in children, adolescents, and adults resident in an indigenous community in Oaxaca who were measured on two or three occasions across surveys in 1968, 1978, and 2000.MethodsThe three cross‐sectional surveys included measures of height, weight, sitting height, arm circumference, triceps skinfold, and grip strength in surveys of schoolchildren in 1968 and of schoolchildren, adolescents and adults in 1978 and 2000. Cross‐checks of surnames, forenames and ages/dates of birth of participants in the three surveys identified three samples of individuals measured on two occasions (1968–1978, two age groups in 1978–2000) and a subsample of individuals measured in the three surveys. Partial correlations controlling for age at each observation were calculated for each variable in the three sex‐specific samples measured on two occasions, and for the subsamples of males and females measured on three occasions.ResultsAllowing for variation in age among subsamples, inter‐age correlations were moderate to high for stature, moderate for sitting height and estimated leg length, and low to moderate for weight, BMI, arm and estimated arm muscle circumference, triceps skinfold, and grip strength.ConclusionAllowing for the relatively broad chronological age intervals, the inter‐age correlations for height, weight and BMI were at the low end, while those for grip strength and for strength per unit body weight for males (though not females) were generally in the range of correlations noted in studies of European samples. Likely associated with improved health, nutritional, and sanitation conditions, obesity and overweight were emerging among adults by 2000. Obesity and overweight in adults paralleled the introduction of mechanized agriculture that reduced routine physical work. Among children, the association of obesity and overweight is likely with increased nutritional availability, but poor choices in diet.
Hypertension and cerebral blood flow in the development of Alzheimer's disease
Authors: Bachmann Dario , Saake Antje , Studer Sandro , Buchmann Andreas , Rauen Katrin , Gruber Esmeralda , Michels Lars , Nitsch Roger M. , Hock Christoph , Gietl Anton , Treyer Valerie ,   for the Alzheimer's Disease Neuroimaging Initiative
Published: September 2024

AbstractINTRODUCTIONWe investigated the interactive associations between amyloid and hypertension on the entorhinal cortex (EC) tau and atrophy and the role of cerebral blood flow (CBF) as a shared mechanism by which amyloid and hypertension contribute to EC tau and regional white matter hyperintensities (WMHs).METHODSWe analyzed data from older adults without dementia participating in the Add‐Tau study (NCT02958670, n = 138) or Alzheimer's Disease Neuroimaging Initiative (ADNI) (n = 523) who had available amyloid‐positron emission tomography (PET), tau‐PET, fluid‐attenuated inversion recovery (FLAIR), and T1‐weighted magnetic resonance imaging (MRI). A subsample in both cohorts had available arterial spin labeling (ASL) MRI (Add‐Tau: n = 78; ADNI: n = 89).RESULTSThe detrimental effects of hypertension on AD pathology and EC thickness were more pronounced in the Add‐Tau cohort. Increased amyloid burden was associated with decreased occipital gray matter CBF in the ADNI cohort. In both cohorts, lower regional gray matter CBF was associated with higher EC tau and posterior WMH burden.DISCUSSIONReduced cerebral perfusion may be one common mechanism through which hypertension and amyloid are related to increased EC tau and WMH volume.Highlights
Hypertension is associated with increased entorhinal cortex (EC) tau, particularly in the presence of amyloid.
Decreased cortical cerebral blood flow (CBF) is associated with higher regional white matter hyperintensity volume.
Increasing amyloid burden is associated with decreasing CBF in the occipital lobe.
MTL CBF and amyloid are synergistically associated with EC tau.