bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Experiment in Field Archaeology
Authors: Ashbee Paul , Cornwall Ian W. 
Published: August 2016

Ideas about the prehistoric past have for long been based upon pieces dug from the mounds and hollows which are the remains of man’s activities. Only recently has it been clearly realized that monuments are continually being modified by nature and that evidence of weathering, denudation and silting can be as informative as the artifacts sometimes found in them. A recent conference showed that there was relatively little exact knowledge of how such processes take place and, in particular, of their quantitative aspects. As has been recently emphasized archaeological excavation is a means of investigating the truth of an hypothesis by destructive analysis. It thus emerges that any study of the action and interaction of natural processes affecting a prehistoric monument must clearly involve the converse, i.e. a monument must be built and studied, in all its component parts, under controlled conditions. Today an impressive and substantial ditch and bank, cut into and heaped upon the chalk of Overton Down in Wiltshire, stands a shining witness to the execution of this principle.The work of construction was undertaken with hand tools, but not all of these were modern picks and shovels. A part of the bank was dug and heaped with primitive tools and appliances—antler picks, shoulder-blade shovels and wicker carrying-baskets. It has long been known (from the not infrequent discovery of examples apparently discarded) that antler picks were the primary digging tools of those who dug the ditches and heaped the long and round barrows, the causewayed camps, the henges and the cursuses, but precise appreciation of the real potentialities of antler picks was slight. Greenwell and Pitt Rivers commented upon the use of such implements, while the subject was pursued in some detail by Horace Sandars in his paper On the Deer Horn Pick in the Mining Operations of the Ancients, among others. Curwen’s accounts of the Sussex flint mines further stimulated such studies as did Clark and Piggott’s classic paper. From Sandars’s, Curwen’s initial and subsequent study and from summaries of the past two decades the view emerged that the antler picks were almost invariably used as punches and levers to break up chalk. Thus, such thought as has been given to prehistoric mining and digging has been to some extent inhibited by acceptance of that notion.
Sir John Marshall and Gandhāra Art
Authors: Schlumberger Daniel 
Published: August 2016

As the Director of the Archaeological Survey of India for more than thirty years, at a time when new finds of Gandhāra art were constantly pouring in, as the excavator of Taxila, as an excavator in Gandhāra itself, Sir John Marshall has had a unique opportunity of building up first-hand knowledge of Gandhāra art. That his views on this great subject should be made known was most desirable, and the Department of Archaeology in Pakistan is to be thanked for having undertaken to publish this volume.The illustration is abundant and, nearly all of it, excellent. It consists of 152 photographs, of sufficient size (in happy contrast with most of the pictures in Foucher’s Art grécobouddhique, and in some of Sir John Marshall’s own publications, Taxila included), carefully selected and arranged in order to exemplify the development of .‘the Early School’, as seen by Sir John. Many a piece is here properly reproduced for the first time. As a compendium of good pictures the volume will be most useful.But the book is far more than just an album of well-chosen photographs, with commentary. As the subtitle says, it is a story. This story is told in twelve chapters. An introduction (Chapter 1) deals with the beginnings of Buddhism in India, and with the problem of how Buddhism fared under the Greek princes of the North-West during the second century B.C.… Among the myriads of Buddhist monuments that are preserved there is not one that can be referred with certainty to Greek authorship in that period (p. 4). Chapter 2 is about the Early Indian school of Art. Then come three chapters on the origins: Chapter 3, The Beginning of Gandhāra art: the Šaka period; Chapter 4, The Renaissance of Hellenistic art under the Parthians and its eflect on Gandhāra art; Chapter 5, Childhood of Gandhāra art. To Adolescence two chapters are devoted (Chapters 6 and 7), to Maturity four: Chapter 8 deals with the Period of Maturity in general; Chapter 9 with the Early Maturity period; the two following ones deal with the Later Maturity period, Chapter 10 with the reliefs, and Chapter 11 is about images and decorative carvings. Chapter 12 gives the conclusions.
The Progress of English Place-Name Studies since 1901
Authors: Dickins Bruce 
Published: August 2016

In this article, Professor Bruce Dickins, Emeritus Professor of Anglo-Saxon in the University of Cambridge and sometime Director of the Survey, takes the opportunity of the publication of two general surveys of English Place-Names and of three volumes of the West Riding Survey, to discuss the development of English Place-Name Studies in the last sixty years. The books he here discusses are:–THE ORIGIN OF ENGLISH PLACE-NAMES by P. H. Reaney. London, Routledge and Kegan Paul, 1960 (second impression 1961). pp. x + 278. 32s. net.ENGLISH PLACE-NAMES. By Kenneth Cameron. London, Batsford. 1961. pp. 256 and 8 plates. 30$. net.THE PLACE-NAMES OF THE WEST RIDING OF YORKSHIRE. By A. H. Smith. Parts I-III (English Place-Name Society, Vols. XXX-XXXII). Cambridge, University Press, 1961. pp. xii + 346 + map, pp. xii + 322 + map, pp. xiv + 278 + map. 35s. net per volume.
The Neolithic Site of Bylany
Authors: Soudský Bohumil 
Published: August 2016

Since 1950, the attention of the Czechoslovak Archaeological Institute has been focused on the study of the Early Neolithic in Czechoslovakia, and since 1960 the investigation of Neolithic society in all its aspects has been one of the principal assignments of the Academy of Sciences in the field of social sciences.In the years 1950-1952 a survey of a Neolithic site of the Danubian I or Bandkeramik, and Late Lengyel cultures, at Postoloprq in NW Bohemia, was undertaken and its results are now in the press. This investigation has shown, however, that NW Bohemia belongs to a peripheral region and that thus any findings made there have a local validity only. Unless they are taken in conjunction with evidence from a less peripheral region, they present a very distorted picture. For this reason a suitable site was looked for in eastern Bohemia, where it could be assumed (on the basis of an analysis of earlier finds in local museums) that particularly suitable localities could be found in the region.
Photonic Weyl degeneracies in magnetized plasma
Authors: Gao Wenlong , Yang Biao , Lawrence Mark , Fang Fengzhou , Béri Benjamin , Zhang Shuang 
Published: August 2016

AbstractWeyl particles are elusive relativistic fermionic particles with vanishing mass. While not having been found as an elementary particle, they are found to emerge in solid-state materials where three-dimensional bands develop a topologically protected point-like crossing, a so-called Weyl point. Photonic Weyl points have been recently realised in three-dimensional photonic crystals with complex structures. Here we report the presence of a novel type of plasmonic Weyl points in a naturally existing medium—magnetized plasma, in which Weyl points arise as crossings between purely longitudinal plasma modes and transverse helical propagating modes. These photonic Weyl points are right at the critical transition between a Weyl point with the traditional closed finite equifrequency surfaces and the newly proposed ‘type II’ Weyl points with open equifrequency surfaces. Striking observable features of plasmon Weyl points include a half k-plane chirality manifested in electromagnetic reflection. Our study introduces Weyl physics into homogeneous photonic media, which could pave way for realizing new topological photonic devices.
miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF
Authors: Wu Qiuyun , Han Lei , Yan Weiwen , Ji Xiaoming , Han Ruhui , Yang Jingjin , Yuan Jiali , Ni Chunhui 
Published: August 2016

AbstractSilicosis is an incurable occupational disease associated with inflammation, fibroblast proliferation and the accumulation of extracellular matrix in lung tissues. The dysregulation of lncRNAs and miRNAs has been implicated in many complex diseases; however, the current understanding of their roles in fibrotic lung diseases, especially silicosis, remains limited. Our previous microRNA (miRNA, miR) microarray data have indicated decreased expression levels of miR-489 in lung tissues of silica-induced pulmonary fibrosis. Here, we further explored the role of miR-489 in a mouse model of silicosis. Interestingly, miR-489 levels were reduced in both macrophages that were exposed to silica and fibroblasts that were exposed to TGF-β1. Additionally, the overexpressed miR-489 carried out its anti-fibrotic role by attenuating inflammation and fibrotic progression in vivo. Our molecular study further demonstrated that miR-489 inhibited silica-induced pulmonary fibrosis primarily by repressing its target genes MyD88 and Smad3. Moreover, the up-regulated lncRNA cardiac hypertrophy-related factor (CHRF) reversed the inhibitory effect of miR-489 on MyD88 and Smad3 and then triggered the inflammation and fibrotic signaling pathways. Overall, our data indicate that the CHRF-miR-489-MyD88 Smad3 signaling axis exerts key functions in silica-induced pulmonary fibrosis and may represent a therapeutic target for silicosis.
Intercellular ultrafast Ca2+ wave in vascular smooth muscle cells: numerical and experimental study
Authors: Quijano J. C. , Raynaud F. , Nguyen D. , Piacentini N. , Meister J. J. 
Published: August 2016

AbstractVascular smooth muscle cells exhibit intercellular Ca2+ waves in response to local mechanical or KCl stimulation. Recently, a new type of intercellular Ca2+ wave was observed in vitro in a linear arrangement of smooth muscle cells. The intercellular wave was denominated ultrafast Ca2+ wave and it was suggested to be the result of the interplay between membrane potential and Ca2+ dynamics which depended on influx of extracellular Ca2+, cell membrane depolarization and its intercel- lular propagation. In the present study we measured experimentally the conduction velocity of the membrane depolarization and performed simulations of the ultrafast Ca2+ wave along coupled smooth muscle cells. Numerical results reproduced a wide spectrum of experimental observations, including Ca2+ wave velocity, electrotonic membrane depolarization along the network, effects of inhibitors and independence of the Ca2+ wave speed on the intracellular stores. The numerical data also provided new physiological insights suggesting ranges of crucial model parameters that may be altered experimentally and that could significantly affect wave kinetics allowing the modulation of the wave characteristics experimentally. Numerical and experimental results supported the hypothesis that the propagation of membrane depolarization acts as an intercellular messenger mediating intercellular ultrafast Ca2+ waves in smooth muscle cells.
Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria
Authors: Tran Tuan M. , Jones Marcus B. , Ongoiba Aissata , Bijker Else M. , Schats Remko , Venepally Pratap , Skinner Jeff , Doumbo Safiatou , Quinten Edwin , Visser Leo G. , Whalen Elizabeth , Presnell Scott , O’Connell Elise M. , Kayentao Kassoum , Doumbo Ogobara K. , Chaussabel Damien , Lorenzi Hernan , Nutman Thomas B. , Ottenhoff Tom H. M. , Haks Mariëlle C. , Traore Boubacar , Kirkness Ewen F. , Sauerwein Robert W. , Crompton Peter D. 
Published: August 2016

AbstractIdentifying molecular predictors and mechanisms of malaria disease is important for understanding how Plasmodium falciparum malaria is controlled. Transcriptomic studies in humans have so far been limited to retrospective analysis of blood samples from clinical cases. In this prospective, proof-of-principle study, we compared whole-blood RNA-seq profiles at pre-and post-infection time points from Malian adults who were either asymptomatic (n = 5) or febrile (n = 3) during their first seasonal PCR-positive P. falciparum infection with those from malaria-naïve Dutch adults after a single controlled human malaria infection (n = 5). Our data show a graded activation of pathways downstream of pro-inflammatory cytokines, with the highest activation in malaria-naïve Dutch individuals and significantly reduced activation in malaria-experienced Malians. Newly febrile and asymptomatic infections in Malians were statistically indistinguishable except for genes activated by pro-inflammatory cytokines. The combined data provide a molecular basis for the development of a pyrogenic threshold as individuals acquire immunity to clinical malaria.
In vitro Characterization of Phenylacetate Decarboxylase, a Novel Enzyme Catalyzing Toluene Biosynthesis in an Anaerobic Microbial Community
Authors: Zargar K. , Saville R. , Phelan R. M. , Tringe S. G. , Petzold C. J. , Keasling J. D. , Beller H. R. 
Published: August 2016

AbstractAnaerobic bacterial biosynthesis of toluene from phenylacetate was reported more than two decades ago, but the biochemistry underlying this novel metabolism has never been elucidated. Here we report results of in vitro characterization studies of a novel phenylacetate decarboxylase from an anaerobic, sewage-derived enrichment culture that quantitatively produces toluene from phenylacetate; complementary metagenomic and metaproteomic analyses are also presented. Among the noteworthy findings is that this enzyme is not the well-characterized clostridial p-hydroxyphenylacetate decarboxylase (CsdBC). However, the toluene synthase under study appears to be able to catalyze both phenylacetate and p-hydroxyphenylacetate decarboxylation. Observations suggesting that phenylacetate and p-hydroxyphenylacetate decarboxylation in complex cell-free extracts were catalyzed by the same enzyme include the following: (i) the specific activity for both substrates was comparable in cell-free extracts, (ii) the two activities displayed identical behavior during chromatographic separation of cell-free extracts, (iii) both activities were irreversibly inactivated upon exposure to O2 and (iv) both activities were similarly inhibited by an amide analog of p-hydroxyphenylacetate. Based upon these and other data, we hypothesize that the toluene synthase reaction involves a glycyl radical decarboxylase. This first-time study of the phenylacetate decarboxylase reaction constitutes an important step in understanding and ultimately harnessing it for making bio-based toluene.
Enemies with benefits: parasitic endoliths protect mussels against heat stress
Authors: Zardi G. I. , Nicastro K. R. , McQuaid C. D. , Ng T. P. T. , Lathlean J. , Seuront L. 
Published: August 2016

AbstractPositive and negative aspects of species interactions can be context dependant and strongly affected by environmental conditions. We tested the hypothesis that, during periods of intense heat stress, parasitic phototrophic endoliths that fatally degrade mollusc shells can benefit their mussel hosts. Endolithic infestation significantly reduced body temperatures of sun-exposed mussels and, during unusually extreme heat stress, parasitised individuals suffered lower mortality rates than non-parasitised hosts. This beneficial effect was related to the white discolouration caused by the excavation activity of endoliths. Under climate warming, species relationships may be drastically realigned and conditional benefits of phototrophic endolithic parasites may become more important than the costs of infestation.
Lyme disease and relapsing feverBorreliaelongate through zones of peptidoglycan synthesis that mark division sites of daughter cells
Authors: Jutras Brandon Lyon , Scott Molly , Parry Bradley , Biboy Jacob , Gray Joe , Vollmer Waldemar , Jacobs-Wagner Christine 
Published: August 2016

SignificanceSpirochetes pose a significant threat to human and animal health, yet little is understood about how these bacteria grow and divide. We discovered that Lyme disease and relapsing fever spirochetes elongate by synthesizing peptidoglycan, a major component of the cell wall, in discrete zones that are spatially regulated over the cell cycle. Zones of cell growth are established in the previous generation and mark future sites of cell division in the next cell cycle. In contrast, other genera display nearly uniform cell wall synthesis, which is commonly reported in bacteria. The distinctive mode of growth exhibited by the Lyme disease and relapsing fever spirochetes may provide an avenue for the strategic design of targeted antimicrobial therapies.
Using visual guidance to retrain an experienced golfer's gaze: A case study
Authors: Bishop Daniel T. , Addington Neil , D'Innocenzo Giorgia 
Published: August 2016

AbstractEye movements are essential for both predictive and reactive control of complex motor skills such as the golf swing. We examined the use of a visually guided learning protocol to retrain an experienced golfer's point‐of‐gaze immediately prior to execution of the full golf swing; his swing, and his gaze behaviour, had become established over more than a decade of practice and competition. Performance and eye movement data were obtained, from baseline, through intervention, to retention, for a total of 159 shots struck at a target 200 yards away. Results show that, at baseline, not only was the golfer's point‐of‐gaze not at the intended/predicted location, at the top‐rear of the ball, but there was also high trial‐to‐trial variability. A bespoke visual guidance protocol improved his gaze behaviour considerably, in terms of accuracy and consistency – and this was reflected in accuracy and consistency of his shots. Implications of oculomotor interventions for the relearning of established motor skills are discussed.
Self-Monitoring of Intraocular Pressure Outside of Normal Office Hours Using Rebound Tonometry: Initial Clinical Experience in Patients With Normal Tension Glaucoma
Authors: Sood Vaneeta , Ramanathan Uthaya S. 
Published: August 2016

Purpose:
To determine the value and accuracy of 24-hour intraocular pressure (IOP) phasing using Icare ONE rebound tonometry (RTONE), in subjects with normal tension glaucoma (NTG).

Methods:
Eighteen consecutive patients with treated NTG were studied, all subjects had undergone 24-hour IOP phasing during a 1-year period. Each patient had daytime (08:00 to 16:00) IOP phasing with Goldmann applanation tonometer at 2-hourly intervals; at these same time points an IOP reading was also obtained by the patient using RTONE. Self-measured IOPs were then recorded at home using RTONE between 18:00 and 06:00 (at 2-hourly intervals). The frequency with which the phasing results altered clinical management was evaluated.

Results:
The mean peak IOP was significantly higher during nighttime phasing (15.78±4.8 mm Hg) compared with daytime phasing (12.83±2.7 mm Hg, P=0.0018) and clinic IOP measurements (11.8±1.6 mm Hg, P<0.0001). Following IOP phasing a change in management occurred in 10 of 18 patients (56%). In the majority of these patients, a peak IOP was identified during nighttime phasing compared with daytime phasing, this difference was significant (P=0.0090). There were strong correlations between the IOP measurements obtained with Goldmann applanation tonometer and RTONE (Spearman r values >0.60, P<0.001).

Conclusions:
This study suggests that in patients with NTG with progression that is disproportionate to their clinic IOP measurements, 24-hour phasing can reveal higher IOP spikes than those identified during typical office hours. RTONE is a safe, easy to use, and accurate device for self-monitoring of IOP.
Increased Partner Risk Characteristic Among Adolescents Using Alcohol In the Moment
Authors: Staras Stephanie AS. , Livingston Melvin D. , Komro Kelli A. 
Published: August 2016

Background
Alcohol is a recognized risk factor for sexually transmitted diseases acquisition, but the mechanism is unclear. Potentially, adolescents using alcohol in the 2 hours before sex (in-the-moment use) have riskier sexual partners.

Methods
We used multivariable logistic regression to examine the association between in-the-moment alcohol use and partner risk characteristics reported for the most recent sex among primarily 17- to 18-year-old adolescents originally recruited from a representative sample of Chicago public elementary schools. We created 3 composite partner risk profiles: partner familiarity risk (casual and unexpected), partner context risk (age discordance and met in public), and overall risk using all measures except partner alcohol use.

Results
Teens who reported any in-the-moment alcohol use were more likely than nondrinking teens to report casual (adjusted odds ratio [AOR], 3.2; 95% confidence interval [95% CI], 2.1–4.9), unexpected (AOR, 1.6; 95% CI, 1.0–2.5), age discordant (AOR, 3.0; 95% CI, 2.0–4.6), or met in public partners (AOR, 1.4; 95% CI, 1.0 to 2.1). For each composite measure, the number of partner risk characteristics reported increased linearly with the percent of teens drinking in the moment (Cochran-Armitage trend, P < 0.0001). Compared with zero characteristics, in-the-moment alcohol use was associated with increased odds of reporting 1 (AOR, 2.8; 95% CI, 1.7–4.5), 2 (AOR, 4.6; 95% CI, 2.7, 7.6), or 3 to 4 characteristics (AOR, 7.1; 95% CI, 3.3–15.3).

Conclusions
Our findings expand the link between in-the-moment alcohol use and partner risk reported in prior studies to encompass adolescents' general sexual experiences and additional partner characteristics including the highly associated composite characteristics.
A Daily Diary Analysis of Condom Breakage and Slippage During Vaginal Sex or Anal Sex Among Adolescent Women
Authors: Hensel Devon J. , Selby Sarah , Tanner Amanda E. , Fortenberry J. Dennis 
Published: August 2016

Background
Adolescent women are disproportionately impacted by the adverse outcomes associated with sexual activity, including sexually transmitted infections (STI). Condoms as a means of prevention relies on use that is free of usage failure, including breakage and/or slippage. This study examined the daily prevalence of and predictors of condom breakage and/or slippage during vaginal sex and during anal sex among adolescent women.

Methods
Adolescent women (N = 387; 14 to 17 years) were recruited from primary care clinics for a longitudinal cohort study of STIs and sexual behavior. Data were daily partner-specific sexual diaries. Random intercept mixed-effects logistic regression was used to estimate the fixed effect of each predictor on condom breakage/slippage during vaginal or during anal sex (Stata, 13.0), adjusting model coefficients for the correlation between repeated within-participant diary entries.

Results
Condom slippage and/or breakage varied across sexual behaviors and was associated with individual-specific (eg, age and sexual interest) and partner-specific factors (eg, negativity). Recent behavioral factors (eg, experiencing slippage and/or breakage in the past week) were the strongest predictors of current condom slippage and/or breakage during vaginal or anal sex.

Conclusions
Factors associated with young women's condom breakage/slippage during vaginal or during anal sex should be integrated as part of STI prevention efforts and should be assessed as part of ongoing routine clinical care.