bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Contribution of Malodour in Quality of Life of Patients With Hidradenitis Suppurativa
Authors: Alavi Afsaneh , Farzanfar Delaram , Lee Rosa Kyuwon , Almutairi Dalal 
Published: December 2017

Background: Malodourous discharge in patients with hidradenitis suppurativa (HS) has a strong psychosocial impact and is often reported as a source of embarrassment, low self-esteem, social stigma, and barriers to interpersonal relationships. Malodour is a maker of bacterial colonization, and its role in HS is understudied. Objectives: The aim of this study is to assess the relationship between severity of malodourous discharge and quality-of-life impairment in patients with HS. Methods: This is a cross-sectional study of 51 patients recruited from the Women’s College Hospital and the York Dermatology Centre. Quality of life was assessed using both the Dermatology Life Quality Index (DLQI) and the Skindex-29 instruments. Results: Severity of odour significantly predicts the total Skindex score after controlling for disease severity as measured by the Hurley stage and Sartorius score ( R2 = 0.39, F = 8.11, P < .0001). However, odour severity is not a predictor of DLQI ( R2 = 0.17, F = 2.63, P = .064). There was no difference in mean DLQI scores for the low- vs high-odour groups, but patients with high odour had a greater quality of life impairment as measured by the Skindex tool ( t = −4.19, df = 43, P < .0001, mean difference = −18.87). Conclusion: Malodour is a common symptom that significantly impairs quality of life in patients with HS. The fact that this effect is captured in Skindex and not the DLQI may be attributed to the nonspecificity of the DLQI in terms of unique disease characteristics. It is important to address odour in the management of patients with HS.
Effects of telephone call intervention on cardiovascular risk factors in T2DM: A meta-analysis
Authors: Wei Junping , Zheng Huijuan , Wang Liansheng , Wang Qiuhong , Wei Fan , Bai Litao 
Published: December 2017

Background Mobile health interventions utilising telephone calls are promising tools for diabetes management. However, there is still a lack of convincing evidence demonstrating their beneficial effects on cardiovascular risk factors. The aim of this meta-analysis of randomised controlled trials was to assess the effect of telephone calls on glycaemic control and other cardiovascular risk factors in type 2 diabetes mellitus patients. Methods Two independent reviewers searched three online databases (PubMed, the Cochrane Library and EMBASE) to identify relevant English-language randomised controlled trials up to September 2017. Randomised controlled trials that assessed the effects of telephone calls on glycaemic control and other cardiovascular risk factors in type 2 diabetes mellitus patients were included. Effect size was calculated for changes in glycosylated haemoglobin A1c, weight, blood pressure and lipid levels using fixed- or random-effects models. Results Eighteen studies involving 3954 patients were included in the meta-analysis. Compared with usual care, telephone calls significantly decreased glycosylated haemoglobin A1c, by 0.12% (95% confidence interval: −0.22% to −0.02%). Univariate regression analysis showed that none of the covariates (number of participants, baseline age, baseline glycosylated haemoglobin A1c, duration of diabetes, call maker, number of calls and duration of study) had an impact on glycosylated haemoglobin A1c. For other cardiovascular risk factors, telephone calls significantly reduced systolic blood pressure by 0.19 mm Hg (95% confidence interval: −0.34% to −0.03%) but non-significantly changed diastolic blood pressure, body mass index, low-density lipoprotein cholesterol, total cholesterol, triglyceride or high-density cholesterol levels. Conclusions This meta-analysis supports the hypothesis that telephone calls offer moderate benefits for glycosylated haemoglobin A1c and systolic blood pressure reduction among type 2 diabetes mellitus patients. However, the data remain insufficient regarding the association of telephone calls with lowered diastolic blood pressure, body mass index or improved lipoprotein profiles.
Urinary protein biomarkers of kidney injury in patients receiving cisplatin chemotherapy
Authors: George Blessy , Joy Melanie S , Aleksunes Lauren M 
Published: December 2017

Despite recent progress in the development of novel approaches to treat cancer, traditional antineoplastic drugs, such as cisplatin, remain a mainstay of regimens targeting solid tumors. Use of cisplatin is limited by acute kidney injury, which occurs in approximately 30% of patients. Current clinical measures, such as serum creatinine and estimated glomerular filtration rate, are inadequate in their ability to detect acute kidney injury, particularly when there is only a moderate degree of injury. Thus, there is an urgent need for improved diagnostic biomarkers to predict nephrotoxicity. There is also interest by the U.S. Food and Drug Administration to validate and implement new biomarkers to identify clinical and subclinical acute kidney injury in patients during the drug approval process. This minireview provides an overview of the current literature regarding the utility of urinary proteins (albumin, beta-2-microglobulin, N-acetyl-D-glucosaminidase, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and cystatin C) as biomarkers for cisplatin-induced AKI. Many of the well-studied urinary proteins (KIM-1, NGAL, B2M, albumin) as well as emerging biomarkers (calbindin, monocyte chemotactic protein-1, and trefoil factor 3) display distinct patterns of time-dependent excretion after cisplatin administration. Implementation of these biomarker proteins in the oncology clinic has been hampered by a lack of validation studies. To address these issues, large head-to-head studies are needed to fully characterize time-dependent responses and establish accurate cutoff values and ranges, particularly in cancer patients.Impact statementThere is growing interest in using urinary protein biomarkers to detect acute kidney injury in oncology patients prescribed the nephrotoxic anticancer drug cisplatin. We aim to synthesize and organize the existing literature on biomarkers examined clinically in patients receiving cisplatin-containing chemotherapy regimens. This minireview highlights several proteins (kidney injury molecule-1, beta-2-microglobulin, neutrophil gelatinase-associated lipocalin, calbindin, monocyte chemotactic protein-1, trefoil factor 3) with the greatest promise for detecting cisplatin-induced acute kidney injury in humans. A comprehensive review of the existing literature may aid in the design of larger studies needed to implement the clinical use of these urinary proteins as biomarkers of kidney injury.
Intracranial contrast transit times on digital subtraction angiography decrease more in patients with delayed intraparenchymal hemorrhage after Pipeline
Authors: Brunozzi Denise , Shakur Sophia F , Charbel Fady T , Alaraj Ali 
Published: December 2017

Background Pipeline embolization devices (PEDs) are used for endovascular treatment of cerebral aneurysms but can be associated with delayed ipsilateral intraparenchymal hemorrhage (DIPH). Changes in intracranial hemodynamics after PED are poorly understood. Objective Here, we assess hemodynamic changes after PED in patients and compare these changes in patients with and without DIPH (DIPH+ and DIPH–). Methods Records of patients with distal internal carotid artery (ICA) aneurysms treated with PED at our institution between 2012 and 2017 were retrospectively reviewed. Regions of interest were selected proximally to PED over the cavernous ICA and distally over the middle cerebral artery (MCA), and then transit times were determined using syngo iFlow software (Siemens). Ratio of MCA to ICA transit time was compared before, after treatment, and at follow-up. Ratios were also compared between DIPH+ and DIPH– subgroups. Correlations between aneurysm size, age, and ratios were investigated. Results Fifty-three patients were included. The ratio of MCA to ICA transit time decreased significantly after PED deployment (1.13 vs. 1.22, p < 0.01). The ratio in the DIPH + subgroup ( n = 4) was significantly lower (1.00 vs. 1.14, p = 0.01) and decreased significantly more (21% vs. 4.4%, p = 0.02) compared to the DIPH– subgroup ( n = 49). The ratio tended to be higher in larger aneurysms at baseline ( r = 0.25, p = 0.07) but not after PED treatment ( r = 0.11, p = 0.15). Age did not correlate with ratio. Conclusion The ratio of MCA to ICA transit time decreases following PED treatment and decreases more in patients with DIPH. These contrast transit time changes can be detected in real time immediately after PED deployment.
Preventing DVT: A Perioperative Perspective
Authors: Ryan Karena , Johnson Sue 
Published: December 2017

In the absence of thromboprophylaxis, deep vein thrombosis (DVT) is a significant risk for surgical patients especially those undergoing orthopaedic surgery and lengthy procedures (ICS 2002, SIGN 2002, Geerts et al 2004, ICS 2006, NICE 2007). Venous thromboembolism (VTE) is preventable; however it kills 25,000 patients each year in the UK. This article reviews relevant literature regarding thromboprophylaxis, and focuses particularly on the use of intermittent pneumatic devices (IPC) within the perioperative environment.
Commissioning the Ideal Perioperative Suite: Is Going it Alone Your Best Option?
Authors: Bielby Ray 
Published: December 2017

Commissioning the ideal perioperative suite, what does it really mean to the perioperative manager? Negotiating through the maze of design, furniture and equipment needs in healthcare building projects requires a great deal of time and input and there will be many questions the perioperative manager will need to ask if they are to undertake this role effectively. What do they need to know and how do they ensure that their department is represented fairly in the building and procurement selection process? What do they really know about project management and how to be a successful and valuable member of a project team? What are the fundamentals that every perioperative manager who is seconded onto a project team needs to be aware of when asked to assist with the fit out and design of a new perioperative suite? If going it alone isn't the best option where can they go to find the right professional help? Is engaging a medical equipment planner the answer?
A Student Perspective: Navigating through the Complexities of Perioperative Practice (Part 1)
Authors: Crowley Aidan J 
Published: December 2017

This article is one of many written by a student operating department practitioner (ODP) telling their story from the day they entered the operating theatre. Their intention is to share reflections and tips on how they coped with the overwhelming, complex and diverse aspects of perioperative practice. Qui non est hodie cras minus aptus erit …He who is not prepared today will be less so tomorrow - Ovid
Reducing the Risk of Surgical Site Infection: A Case Controlled Study of Contamination of Theatre Clothing
Authors: Sivanandan Indu , Bowker Karen E , Bannister Gordon C , Soar Jasmeet 
Published: December 2017

Surgical site infections are one of the most important causes of healthcare associated infections (HCAI), accounting for 20% of all HCAIs. Surgical site infections affect 1% of joint replacement operations. This study was designed to assess whether theatre clothing is contaminated more inside or outside the theatre suite. Petri dishes filled with horse blood agar were pressed on theatre clothes at 0, 2, 4, 6 and 8 hours to sample bacterial contamination in 20 doctors whilst working in and outside the theatre suite. The results showed that there was greater bacterial contamination when outside the theatre suite at 2 hours. There were no differences in the amount of contamination at 4, 6 and 8 hours. This study suggests that the level of contamination of theatre clothes is similar both inside and outside the theatre setting.
Epidemiology of Injuries Sustained as a Result of Intentional Player Contact in High School Football, Ice Hockey, and Lacrosse: 2005-2006 Through 2015-2016
Authors: Bartley Justin H. , Murray Monica F. , Kraeutler Matthew J. , Pierpoint Lauren A. , Welton K. Linnea , McCarty Eric C. , Comstock R. Dawn 
Published: December 2017

Background: Lacrosse and ice hockey are quickly growing in popularity, while football remains the most popular sport among high school student-athletes. Injuries remain a concern, given the physical nature of these contact sports. Purpose: To describe the rates and patterns of injuries sustained as a result of intentional player contact in United States high school boys’ football, ice hockey, and lacrosse. Study Design: Descriptive epidemiology study. Methods: We conducted a secondary analysis of High School RIO (Reporting Information Online) data, including exposure and injury data collected from a large sample of high schools in the United States from 2005-2006 through 2015-2016. Data were analyzed to calculate rates, assess patterns, and evaluate potential risk factors for player-to-player contact injuries. Results: A total of 34,532 injuries in boys’ football, ice hockey, and lacrosse occurred during 9,078,902 athlete-exposures (AEs), for a rate of 3.80 injuries per 1000 AEs in the 3 contact sports of interest. The risk of injuries was found to be greater in competition compared with practice for all 3 sports, with the largest difference in ice hockey (rate ratio, 8.28) and the smallest difference in lacrosse (rate ratio, 3.72). In all 3 contact sports, the most commonly injured body site in competition and practice caused by both tackling/checking and being tackled/checked was the head/face. However, a significantly greater proportion of concussions sustained in football were the result of tackling compared with being tackled (28.2% vs 24.1%, respectively). In addition, a significantly greater proportion of concussions were sustained in competition compared with practice for all 3 sports. Conclusion: This study is the first to collectively compare injury rates and injury patterns sustained from intentional player-to-player contact in boys’ high school football, ice hockey, and lacrosse. Notably, there was a relatively high risk of injuries and concussions during football practices.
Posttraumatic Stress Disorder and Depression Symptom Severities Are Differentially Associated With Hippocampal Subfield Volume Loss in Combat Veterans
Authors: Averill Christopher L. , Satodiya Ritvij M. , Scott J. Cobb , Wrocklage Kristen M. , Schweinsburg Brian , Averill Lynnette A. , Akiki Teddy J. , Amoroso Timothy , Southwick Steven M. , Krystal John H. , Abdallah Chadi G. 
Published: December 2017

Background Two decades of human neuroimaging research have associated volume reductions in the hippocampus with posttraumatic stress disorder. However, little is known about the distribution of volume loss across hippocampal subfields. Recent advances in neuroimaging methods have made it possible to accurately delineate 10 gray matter hippocampal subfields. Here, we apply a volumetric analysis of hippocampal subfields to data from a group of combat-exposed Veterans. Method Veterans (total, n = 68, posttraumatic stress disorder, n = 36; combat control, n = 32) completed high-resolution structural magnetic resonance imaging. Based on previously validated methods, hippocampal subfield volume measurements were conducted using FreeSurfer 6.0. The Clinician-Administered PTSD Scale assessed posttraumatic stress disorder symptom severity; Beck Depression Inventory assessed depressive symptom severity. Controlling for age and intracranial volume, partial correlation analysis examined the relationship between hippocampal subfields and symptom severity. Correction for multiple comparisons was performed using false discovery rate. Gender, intelligence, combat severity, comorbid anxiety, alcohol/substance use disorder, and medication status were investigated as potential confounds. Results In the whole sample, total hippocampal volume negatively correlated with Clinician-Administered PTSD Scale and Beck Depression Inventory scores. Of the 10 hippocampal subfields, Clinician-Administered PTSD Scale symptom severity negatively correlated with the hippocampus–amygdala transition area (HATA). Beck Depression Inventory scores negatively correlated with dentate gyrus, cornu ammonis 4 (CA4), HATA, CA2/3, molecular layer, and CA1. Follow-up analysis limited to the posttraumatic stress disorder group showed a negative correlation between Clinician-Administered PTSD Scale symptom severity and each of HATA, CA2/3, molecular layer, and CA4. Conclusion This study provides the first evidence relating posttraumatic stress disorder and depression symptoms to abnormalities in the HATA, an anterior hippocampal region highly connected to prefrontal-amygdala circuitry. Notably, dentate gyrus abnormalities were associated with depression severity but not posttraumatic stress disorder symptoms. Future confirmatory studies should determine the extent to which dentate gyrus volume can differentiate between posttraumatic stress disorder- and depression-related pathophysiology.
汉字的性质
Authors: 苏培成  
Published: December 2017

摘要 汉字的性质指的是汉字区别于其他文字的本质特征。汉字研究首先要认清汉字的性质。自索绪尔到布龙菲尔德到赵元任、吕叔湘认为汉字是语素文字，这种看法是正确的。本文还批评了两个层次符号的理论。周有光提出的文字三相分类法，充实了文字性质研究的内容。
Proteomic Profiling of Human Uterine Fibroids Reveals Upregulation of the Extracellular Matrix Protein Periostin
Authors: Jamaluddin M Fairuz B , Ko Yi-An , Kumar Manish , Brown Yazmin , Bajwa Preety , Nagendra Prathima B , Skerrett-Byrne David A , Hondermarck Hubert , Baker Mark A , Dun Matt D , Scott Rodney J , Nahar Pravin , Tanwar Pradeep S 
Published: December 2017

AbstractThe central characteristic of uterine fibroids is excessive deposition of extracellular matrix (ECM), which contributes to fibroid growth and bulk-type symptoms. Despite this, very little is known about patterns of ECM protein expression in fibroids and whether these are influenced by the most common genetic anomalies, which relate to MED12. We performed extensive genetic and proteomic analyses of clinically annotated fibroids and adjacent normal myometrium to identify the composition and expression patterns of ECM proteins in MED12 mutation–positive and mutation–negative uterine fibroids. Genetic sequencing of tissue samples revealed MED12 alterations in 39 of 65 fibroids (60%) from 14 patients. Using isobaric tagged–based quantitative mass spectrometry on three selected patients (n = 9 fibroids), we observed a common set of upregulated (&gt;1.5-fold) and downregulated (&lt;0.66-fold) proteins in small, medium, and large fibroid samples of annotated MED12 status. These two sets of upregulated and downregulated proteins were the same in all patients, regardless of variations in fibroid size and MED12 status. We then focused on one of the significant upregulated ECM proteins and confirmed the differential expression of periostin using western blotting and immunohistochemical analysis. Our study defined the proteome of uterine fibroids and identified that increased ECM protein expression, in particular periostin, is a hallmark of uterine fibroids regardless of MED12 mutation status. This study sets the foundation for further investigations to analyze the mechanisms regulating ECM overexpression and the functional role of upregulated ECM proteins in leiomyogenesis.
El productor silencioso: destino del gran actor de la modernización de los años 1960-70 en la actual copresencia de agriculturas de la región pampeana argentina // The silent farmer: destiny of the great actor of the modernization of the years 1960–70 in the current copresence of agricultures in the Argentina Pampa
Authors: Albaladejo Christophe , Cittadini Roberto 
Published: December 2017

En la región pampeana argentina, pese a las declaraciones de muchos actores y afirmaciones en la literatura, estimamos que el modelo de agricultura del agribusiness representado por los “nuevos productores” de la soja no puede ser considerado como una profundización del modelo de modernización anterior, de los años 1960-70, sino que debe ser entendido como un proceso nuevo en ruptura con dicha modernización. ¿Cuál es entonces el destino de los actores que eran la base del modelo de modernización anterior y en particular del productor moderno convencional? Surgió paralelamente al agribusiness, y desde los años 2000, un nuevo sujeto social en lo rural argentino: el “productor familiar”. Pero ninguno de los dos sujetos, agricultor familiar y agribusiness, representa lo esencial del productor “moderno” autónomo que estuvo en el centro de la modernización “clásica” de los años 1960-70. En este trabajo mostramos el carácter heurístico de centrar el foco de la atención sobre el destino de la base social de la modernización anterior, y la importancia oculta de su rol actual en los territorios y el agro, pese a su repentina desaparición de los discursos y de las representaciones sociales, así como de las políticas públicas.
Heat generation by eddy currents in a shell of superconducting bus-bars for SIS100 particle accelerator at FAIR
Authors: Tomków Łukasz , Trojanowski Stanisław , Ciszek Marian , Chorowski Maciej 
Published: December 2017

Abstract
Superconducting magnets in the SIS100 particle accelerator require the supply of liquid helium and electric current. Both are transported with by-pass lines designed at Wrocław University of Technology. Bus-bars used to transfer an electric current between the sections of the accelerator will be encased in a steel shell. Eddy currents are expected to appear in the shell during fast-ramp operation of magnets. Heat generation, which should be limited in any cryogenic system, will appear in the shell. In this work the amount of heat generated is assessed depending on the geometry of an assembly of the bus-bars and the shell. Numerical and analytical calculations are described. It was found that heat generation in the shell is relatively small when compared to other sources present in the accelerator and its value strongly depends on the geometry of the shell. The distribution of eddy currents and generated heat for different geometrical options are presented. Based on the results of the calculations the optimal design is proposed.
Concentration-Compactness Principle of Singular Trudinger--Moser Inequalities in ℝ
n
and n-Laplace Equations
Authors: Zhang Caifeng , Chen Lu 
Published: December 2017

Abstract
In this paper, we use the rearrangement-free argument, in the spirit of the work by Li, Lu and Zhu [25], on the concentration-compactness principle on the Heisenberg group to establish a sharpened version of the singular Lions concentration-compactness principle for the Trudinger–Moser inequality in

ℝ
n

{\mathbb{R}^{n}}

. Then we prove a compact embedding theorem, which states that

W

1
,
n

⁢

(

ℝ
n

)

{W^{1,n}(\mathbb{R}^{n})}

is compactly embedded into

L
p

⁢

(

ℝ
n

,

|
x
|

-
β

⁢
d
⁢
x

)

{L^{p}(\mathbb{R}^{n},|x|^{-\beta}\,dx)}

for

p
≥
n

{p\geq n}

and

0
<
β
<
n

{0<\beta<n}

. As an application of the above results, we establish sufficient conditions for the existence of ground state solutions to the following n-Laplace equation with critical nonlinearity:

($*$)

{

-

div
⁡

(

|

∇
⁡
u

|

n
-
2

⁢

∇
⁡
u

)

+

V
⁢

(
x
)

⁢

|
u
|

n
-
2

⁢
u

=

f
⁢

(
x
,
u
)

|
x
|

β

,

u
∈

W

1
,
n

⁢

(

ℝ
n

)

,

u
≥
0

,

{}\left\{\begin{aligned} &\displaystyle{-}\operatorname{div}(|\nabla u|^{n-2}% \nabla u)+V(x)|u|^{n-2}u=\frac{f(x,u)}{|x|^{\beta}},\\ &\displaystyle u\in W^{1,n}(\mathbb{R}^{n}),\quad u\geq 0,\end{aligned}\right.

where

V
⁢

(
x
)

≥

c
0

{V(x)\geq c_{0}}

for some positive constant

c
0

{c_{0}}

and

f
⁢

(
x
,
t
)

{f(x,t)}

behaves like

exp
⁡

(

α
⁢

|
t
|

n

n
-
1

)

{\exp(\alpha|t|^{\frac{n}{n-1}})}

as

t
→

+
∞

{t\rightarrow+\infty}

. This work improves substantially related results found in the literature.