bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressant use and work-related injuries
Authors: Kouvonen A. , Vahtera J. , Pentti J. , Korhonen M. J. , Oksanen T. , Salo P. , Virtanen M. , Kivimäki M. 
Published: January 2016

BackgroundAdverse effects of antidepressants are most common at the beginning of the treatment, but possible also later. We examined the association between antidepressant use and work-related injuries taking into account the duration of antidepressant use.MethodAntidepressant use and work-related injuries between 2000 and 2011 were measured among 66 238 employees (mean age 43.8 years, 80% female) using linkage to national records (the Finnish Public Sector study). We analysed data using time-dependent modelling with individuals as their own controls (self-controlled case-series design).ResultsIn 2238 individuals who had used antidepressants and had a work-related injury during a mean follow-up of 7.8 years, no increase in the risk of injury was observed in the beginning of antidepressant treatment. However, an increased injury risk was seen after 3 months of treatment (rate ratio, compared with no recent antidepressant use, 1.27, 95% confidence interval 1.10–1.48). This was also the case among those who had used only selective serotonin reuptake inhibitors (n = 714; rate ratio 1.41, 95% confidence interval 1.08–1.83).ConclusionsAntidepressant use was not associated with an increased risk of work-related injury at the beginning of treatment. Post-hoc analyses of antidepressant trials are needed to determine whether long-term use of antidepressants increases the risk of work-related injury.
Bullying victimization in adolescence and psychotic symptomatology in adulthood: evidence from a 35-year study
Authors: Boden J. M. , van Stockum S. , Horwood L. J. , Fergusson D. M. 
Published: January 2016

BackgroundThere has been considerable recent interest in possible causal linkages between exposure to bullying victimization and later psychotic symptomatology. Prior research in this area has had several limitations which make it difficult to ascertain causality, and to determine the extent to which these effects extend beyond adolescence.MethodData were obtained from the Christchurch Health and Development Study, a 35-year study of a longitudinal birth cohort. This investigation used generalized estimating equation modelling to estimate the associations between bullying victimization (ages 13–16 years) and psychotic symptoms (ages 18–35 years), before and after controlling for possible confounding factors, including: gender; childhood socio-economic status; child intelligence quotient; exposure to sexual abuse in childhood; anxious/withdrawn behaviour and attention problems (ages 7–9 years); and adolescent psychotic symptoms and paranoid ideation (ages 15–16 years).ResultsThere was a significant (p < 0.0001) bivariate association between bullying victimization in adolescence and psychotic symptomatology in adulthood. Successive models controlling for covariation reduced this association to statistical non-significance. After controlling for covariates, those with the highest level of bullying victimization had rates of psychotic symptoms that were 1.21 (95% confidence interval 0.73–1.99) times higher than those who were not victimized.ConclusionsThe association between bullying victimization in adolescence and psychotic symptomatology in adulthood could be largely explained by childhood behavioural problems, and exposure to sexual abuse in childhood. The results suggest that bullying victimization was unlikely to have been a cause of adult psychotic symptoms, but bullying victimization remained a risk marker for these symptoms.
Another look at πίστις Χριστοῦ
Authors: Hooker Morna D. 
Published: January 2016

AbstractThe debate regarding the meaning of πίστις Χριστοῦ in the Pauline epistles continues and is important because of its implications for theology. In the phrase there is a double ambiguity, which touches not only the significance of the genitive, but also the meaning of πίστις. A brief look at some key texts in Romans suggests that the phrase refers primarily to the faith/faithfulness of Christ, but that this is also something shared by those who are ‘in Christ’. Through Christ God has done what the law could not do, enabling men and women to become his children, and so share not only in Christ's faith but in what he is. The phrase thus represents the ‘delicate balance between human behaviour and divine grace’ that characterises Paul's soteriology.
It's Baaaack: Zeroing, the US Department of Commerce, andUS‒Shrimp II (Viet Nam)
Authors: HARTIGAN JAMES C. 
Published: January 2016

AbstractIn itsFinal Modification for Reviewsthe US DOC announced on 14 February 2012 that it would cease the use of zeroing in the calculation of anti-dumping (AD) margins in all reviews as of 16 April 2012. However, it did not pertain to targeted dumping. In itsFinal Ruleof 22 April 2014, it codified substantial discretion in calculating AD duties, including the use of zeroing, in targeted dumping. Thus the panel inUS‒Shrimp II (Viet Nam)erred in not finding ‘as such’ inconsistency by the US with the AD Agreement, despite this not being a targeted dumping complaint. Given the record of the US in complying with zeroing petitions, it should have incurred the burden of proof, which is not satisfied by these pronouncements. Market structure should be used by panels in ‘as applied’ inconsistency determinations. Viet Nam should have included an Article 3 violation in its complaint.
Editor's Introduction to Volume 40, Issue 1
Authors: McCants Anne EC 
Published: January 2016

With this issue, Social Science History begins its fortieth year of publication. The journal is also in its second year of publication with Cambridge University Press. So this seems an especially propitious moment to take stock of who we are and how we conceive of our mission, to both our parent organization and to the wider world of interdisciplinary scholarly inquiry. Since our founding in 1976, the journal remains firmly rooted in the organizational and intellectual apparatus of the Social Science History Association (SSHA). We embrace the cross-disciplinary and grassroots “network” structure of the annual meetings in forming our Editorial Board, with its rotating membership and diverse representation from across the historical and social science disciplines. We actively seek out new scholarship, as well as encourage SSHA members to propose special issues that address a common theme or scholarly question from multiple disciplinary points of view and address different places and time periods. But we also remain fundamentally historical in our purview, dedicated to “improv[ing] the quality of historical explanation in every manner possible, but particularly by encouraging the selective use and adaptation in historical . . . research of relevant theories and methods from related disciplines, particularly the social sciences.”
Shugoshin forms a specialized chromatin domain at subtelomeres that regulates transcription and replication timing
Authors: Tashiro Sanki , Handa Tetsuya , Matsuda Atsushi , Ban Takuto , Takigawa Toru , Miyasato Kazumi , Ishii Kojiro , Kugou Kazuto , Ohta Kunihiro , Hiraoka Yasushi , Masukata Hisao , Kanoh Junko 
Published: January 2016

AbstractA chromosome is composed of structurally and functionally distinct domains. However, the molecular mechanisms underlying the formation of chromatin structure and the function of subtelomeres, the telomere-adjacent regions, remain obscure. Here we report the roles of the conserved centromeric protein Shugoshin 2 (Sgo2) in defining chromatin structure and functions of the subtelomeres in the fission yeast Schizosaccharomyces pombe. We show that Sgo2 localizes at the subtelomeres preferentially during G2 phase and is essential for the formation of a highly condensed subtelomeric chromatin body ‘knob’. Furthermore, the absence of Sgo2 leads to the derepression of the subtelomeric genes and premature DNA replication at the subtelomeric late origins. Thus, the subtelomeric specialized chromatin domain organized by Sgo2 represses both transcription and replication to ensure proper gene expression and replication timing.
Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane
Authors: Richardson Ben D. , Saha Kaustuv , Krout Danielle , Cabrera Elizabeth , Felts Bruce , Henry L. Keith , Swant Jarod , Zou Mu-Fa , Newman Amy Hauck , Khoshbouei Habibeh 
Published: January 2016

AbstractThe dopaminergic system is essential for cognitive processes, including reward, attention and motor control. In addition to DA release and availability of synaptic DA receptors, timing and magnitude of DA neurotransmission depend on extracellular DA-level regulation by the dopamine transporter (DAT), the membrane expression and trafficking of which are highly dynamic. Data presented here from real-time TIRF (TIRFM) and confocal microscopy coupled with surface biotinylation and electrophysiology suggest that changes in the membrane potential alone, a universal yet dynamic cellular property, rapidly alter trafficking of DAT to and from the surface membrane. Broadly, these findings suggest that cell-surface DAT levels are sensitive to membrane potential changes, which can rapidly drive DAT internalization from and insertion into the cell membrane, thus having an impact on the capacity for DAT to regulate extracellular DA levels.
The architecture of the Schizosaccharomyces pombe CCR4-NOT complex
Authors: Ukleja Marta , Cuellar Jorge , Siwaszek Aleksandra , Kasprzak Joanna M. , Czarnocki-Cieciura Mariusz , Bujnicki Janusz M. , Dziembowski Andrzej , M. Valpuesta Jose 
Published: January 2016

AbstractCCR4-NOT is a large protein complex present both in cytoplasm and the nucleus of eukaryotic cells. Although it is involved in a variety of distinct processes related to expression of genetic information such as poly(A) tail shortening, transcription regulation, nuclear export and protein degradation, there is only fragmentary information available on some of its nine subunits. Here we show a comprehensive structural characterization of the native CCR4-NOT complex from Schizosaccharomyces pombe. Our cryo-EM 3D reconstruction of the complex, combined with techniques such as immunomicroscopy, RNA-nanogold labelling, docking of the available high-resolution structures and models of different subunits and domains, allow us to propose its full molecular architecture. We locate all functionally defined domains endowed with deadenylating and ubiquitinating activities, the nucleus-specific RNA-interacting subunit Mmi1, as well as surfaces responsible for protein–protein interactions. This information provides insight into cooperation of the different CCR4-NOT complex functions.
Evolutionary signals of selection on cognition from the great tit genome and methylome
Authors: Laine Veronika N. , Gossmann Toni I. , Schachtschneider Kyle M. , Garroway Colin J. , Madsen Ole , Verhoeven Koen J. F. , de Jager Victor , Megens Hendrik-Jan , Warren Wesley C. , Minx Patrick , Crooijmans Richard P. M. A. , Corcoran Pádraic ,   The Great Tit HapMap Consortium, Adriaensen Frank , Belda Eduardo , Bushuev Andrey , Cichon Mariusz , Charmantier Anne , Dingemanse Niels , Doligez Blandine , Eeva Tapio , Erikstad Kjell Einar , Fedorov Slava , Hau Michaela , Hille Sabine , Hinde Camilla , Kempenaers Bart , Kerimov Anvar , Krist Milos , Mand Raivo , Matthysen Erik , Nager Reudi , Norte Claudia , Orell Markku , Richner Heinz , Slagsvold Tore , Tilgar Vallo , Tinbergen Joost , Torok Janos , Tschirren Barbara , Yuta Tera , Sheldon Ben C. , Slate Jon , Zeng Kai , van Oers Kees , Visser Marcel E. , Groenen Martien A. M. 
Published: January 2016

AbstractFor over 50 years, the great tit (Parus major) has been a model species for research in evolutionary, ecological and behavioural research; in particular, learning and cognition have been intensively studied. Here, to provide further insight into the molecular mechanisms behind these important traits, we de novo assemble a great tit reference genome and whole-genome re-sequence another 29 individuals from across Europe. We show an overrepresentation of genes related to neuronal functions, learning and cognition in regions under positive selection, as well as increased CpG methylation in these regions. In addition, great tit neuronal non-CpG methylation patterns are very similar to those observed in mammals, suggesting a universal role in neuronal epigenetic regulation which can affect learning-, memory- and experience-induced plasticity. The high-quality great tit genome assembly will play an instrumental role in furthering the integration of ecological, evolutionary, behavioural and genomic approaches in this model species.
Functional annotation of rare gene aberration drivers of pancreatic cancer
Authors: Tsang Yiu Huen , Dogruluk Turgut , Tedeschi Philip M. , Wardwell-Ozgo Joanna , Lu Hengyu , Espitia Maribel , Nair Nikitha , Minelli Rosalba , Chong Zechen , Chen Fengju , Chang Qing Edward , Dennison Jennifer B. , Dogruluk Armel , Li Min , Ying Haoqiang , Bertino Joseph R. , Gingras Marie-Claude , Ittmann Michael , Kerrigan John , Chen Ken , Creighton Chad J. , Eterovic Karina , Mills Gordon B. , Scott Kenneth L. 
Published: January 2016

AbstractAs we enter the era of precision medicine, characterization of cancer genomes will directly influence therapeutic decisions in the clinic. Here we describe a platform enabling functionalization of rare gene mutations through their high-throughput construction, molecular barcoding and delivery to cancer models for in vivo tumour driver screens. We apply these technologies to identify oncogenic drivers of pancreatic ductal adenocarcinoma (PDAC). This approach reveals oncogenic activity for rare gene aberrations in genes including NAD Kinase (NADK), which regulates NADP(H) homeostasis and cellular redox state. We further validate mutant NADK, whose expression provides gain-of-function enzymatic activity leading to a reduction in cellular reactive oxygen species and tumorigenesis, and show that depletion of wild-type NADK in PDAC cell lines attenuates cancer cell growth in vitro and in vivo. These data indicate that annotating rare aberrations can reveal important cancer signalling pathways representing additional therapeutic targets.
Controllable high-fidelity quantum state transfer and entanglement generation in circuit QED
Authors: Xu Peng , Yang Xu-Chen , Mei Feng , Xue Zheng-Yuan 
Published: January 2016

AbstractWe propose a scheme to realize controllable quantum state transfer and entanglement generation among transmon qubits in the typical circuit QED setup based on adiabatic passage. Through designing the time-dependent driven pulses applied on the transmon qubits, we find that fast quantum sate transfer can be achieved between arbitrary two qubits and quantum entanglement among the qubits also can also be engineered. Furthermore, we numerically analyzed the influence of the decoherence on our scheme with the current experimental accessible systematical parameters. The result shows that our scheme is very robust against both the cavity decay and qubit relaxation, the fidelities of the state transfer and entanglement preparation process could be very high. In addition, our scheme is also shown to be insensitive to the inhomogeneous of qubit-resonator coupling strengths.
Boosting spin-caloritronic effects by attractive correlations in molecular junctions
Authors: Weymann Ireneusz 
Published: January 2016

AbstractIn nanoscopic systems quantum confinement and interference can lead to an enhancement of thermoelectric properties as compared to conventional bulk materials. For nanostructures, such as molecules or quantum dots coupled to external leads, the thermoelectric figure of merit can reach or even exceed unity. Moreover, in the presence of external magnetic field or when the leads are ferromagnetic, an applied temperature gradient can generate a spin voltage and an associated spin current flow in the system, which makes such nanostructures particularly interesting for future thermoelectric applications. In this study, by using the numerical renormalization group method, we examine the spin-dependent thermoelectric transport properties of a molecular junction involving an orbital level with attractive Coulomb correlations coupled to ferromagnetic leads. We analyze how attractive correlations affect the spin-resolved transport properties of the system and find a nontrivial dependence of the conductance and tunnel magnetoresistance on the strength and sign of those correlations. We also demonstrate that attractive correlations can lead to an enhancement of the spin thermopower and the figure of merit, which can be controlled by a gate voltage.
Association between Carotid Intima-Media Thickness and Cognitive Impairment in a Chinese Stroke Population: A Cross-sectional Study
Authors: Yue Wei , Wang Anxin , Liang Hui , Hu Fengyun , Zhang Yunshu , Deng Meiying , Li Tong , Hu Xiao , Ye Zhenxuan , Shen Ying , Ji Yong 
Published: January 2016

AbstractThis study aimed to investigate the potential associations between carotid intima-media thickness and cognitive impairment among patients with acute ischemic stroke and to identify the clinical implications. We measured carotid intima-media thickness (IMT) and performed the Mini-Mental State Examination (MMSE) upon the admission of 1,826 acute ischemic stroke patients. The association between IMT and cognitive impairment evaluated by the MMSE was assessed with a multivariate regression analysis. Other clinical variables of interest were also assessed. After adjusting for potential confounders, participants in the highest IMT quartile had a higher likelihood of having cognitive impairments compared with the lowest IMT quartile (odds ratio: 3.01, 95% confidence interval: 2.07–4.37, p < 0.001). Stratified analyses indicated that this positive correlation was similar for the maxIMT and meanIMT of carotid artery measurements. A positive correlation was found between IMT and cognitive impairment in participants with acute ischemic stroke.
Phylogeographic analysis of severe fever with thrombocytopenia syndrome virus from Zhoushan Islands, China: implication for transmission across the ocean
Authors: Fu Yongfeng , Li Shibo , Zhang Zhao , Man Suqin , Li Xueping , Zhang Wenhong , Zhang Chiyu , Cheng Xunjia 
Published: January 2016

AbstractFrom June 2011 to August 2014, 21 cases of infection by severe fever with thrombocytopenia syndrome bunyavirus (SFTSV) were confirmed in Zhoushan Islands in the Eastern coast of China. To identify the source of SFTSV in Zhoushan Islands, the whole SFTSV genomes were amplified and sequenced from 17 of 21 patients. The L, M and S genomic segments of these SFTSV strains were phylogenetically analyzed together with those of 188 SFTSV strains available from GenBank. Phylogenetic analysis demonstrated SFTSV could be classified into six genotypes. The genotypes F, A and D were dominant in mainland China. Additionally, seven types of SFTSV genetic reassortants (abbreviated as AFA, CCD, DDF, DFD, DFF, FAF and FFA for the L, M and S segments) were identified from 10 strains in mainland China. Genotype B was dominant in Zhoushan Islands, Japan and South Korea, but not found in mainland China. Phylogeographic analysis also revealed South Korea possible be the origin area for genotype B and transmitted into Japan and Zhoushan islands in the later part of 20th century. Therefore, we propose that genotype B isolates were probable transmitted from South Korea to Japan and Zhoushan Islands.
Orbital Delocalization and Enhancement of Magnetic Interactions in Perovskite Oxyhydrides
Authors: Liu Kai , Hou Yusheng , Gong Xingao , Xiang Hongjun 
Published: January 2016

AbstractRecent experiments showed that some perovskite oxyhydrides have surprisingly high magnetic-transition temperature. In order to unveil the origin of this interesting phenomenon, we investigate the magnetism in SrCrO2H and SrVO2H on the basis of first-principles calculations and Monte Carlo simulations. Our work indicates that the Cr-O-Cr superexchange interaction in SrCrO2H is unexpectedly strong. Different from the previous explanation in terms of the H− ion substitution induced increase of the Cr-O-Cr bond angle, we reveal instead that this is mainly because the 3d orbitals in perovskite oxyhydrides becomes more delocalized since H− ions have weaker electronegativity and less electrons than O2− ions. The delocalized 3d orbitals result in stronger Cr-O interactions and enhance the magnetic-transition temperature. This novel mechanism is also applicable to the case of SrVO2H. Furthermore, we predict that SrFeO2H will have unprecedented high Neel temperature because of the extraordinarily strong Fe-H-Fe σ-type interactions. Our work suggests the anion substitution can be used to effectively manipulate the magnetic properties of perovskite compounds.
Evaluation of children with ADHD on the Ball-Search Field Task
Authors: Rosetti Marcos F. , Ulloa Rosa E. , Vargas-Vargas Ilse L. , Reyes-Zamorano Ernesto , Palacios-Cruz Lino , de la Peña Francisco , Larralde Hernán , Hudson Robyn 
Published: January 2016

AbstractSearching, defined for the purpose of the present study as the displacement of an individual to locate resources, is a fundamental behavior of all mobile organisms. In humans this behavior underlies many aspects of everyday life, involving cognitive processes such as sustained attention, memory and inhibition. We explored the performance of 36 treatment-free children diagnosed with attention-deficit hyperactivity disorder (ADHD) and 132 children from a control school sample on the ecologically based ball-search field task (BSFT), which required them to locate and collect golf balls in a large outdoor area. Children of both groups enjoyed the task and were motivated to participate in it. However, performance showed that ADHD-diagnosed subjects were significantly less efficient in their searching. We suggest that the BSFT provides a promising basis for developing more complex ecologically-derived tests that might help to better identify particular cognitive processes and impairments associated with ADHD.
Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis
Authors: Youn Hyung-Seop , Kim Tae Gyun , Kim Mun-Kyoung , Kang Gil Bu , Kang Jung Youn , Lee Jung-Gyu , An Jun Yop , Park Kyoung Ryoung , Lee Young jin , Im Young Jun , Lee Jun Hyuck , Eom Soo Hyun 
Published: January 2016

AbstractQuinolinate phosphoribosyltransferase (QPRT) catalyses the production of nicotinic acid mononucleotide, a precursor of de novo biosynthesis of the ubiquitous coenzyme nicotinamide adenine dinucleotide. QPRT is also essential for maintaining the homeostasis of quinolinic acid in the brain, a possible neurotoxin causing various neurodegenerative diseases. Although QPRT has been extensively analysed, the molecular basis of the reaction catalysed by human QPRT remains unclear. Here, we present the crystal structures of hexameric human QPRT in the apo form and its complexes with reactant or product. We found that the interaction between dimeric subunits was dramatically altered during the reaction process by conformational changes of two flexible loops in the active site at the dimer-dimer interface. In addition, the N-terminal short helix α1 was identified as a critical hexamer stabilizer. The structural features, size distribution, heat aggregation and ITC studies of the full-length enzyme and the enzyme lacking helix α1 strongly suggest that human QPRT acts as a hexamer for cooperative reactant binding via three dimeric subunits and maintaining stability. Based on our comparison of human QPRT structures in the apo and complex forms, we propose a drug design strategy targeting malignant glioma.