bluuebunny/crossref_metadata_2025_split huggingface dataset:
Human Viral Oncoproteins and Ubiquitin–Proteasome System
Authors: Atani Zahra Rafiei , Hosseini Sareh Sadat , Goudarzi Hossein , Faghihloo Ebrahim 
Published: September 2024

AbstractSome human cancers worldwide may be related to human tumor viruses. Knowing, controlling, and managing the viruses that cause cancers remain a problem. Also, tumor viruses use ubiquitin–proteasome system (UPS) that can alter host cellular processes through UPS. Human tumor viruses cause persistent infections, due to their ability to infect their host cells without killing them. Tumor viruses such as Epstein–Barr virus, hepatitis C virus, hepatitis B virus, human papillomaviruses, human T cell leukemia virus, Kaposi's sarcoma-associated herpesvirus, and Merkel cell polyomavirus are associated with human malignancies. They interfere with the regulation of cell cycle and control of apoptosis, which are important for cellular functions. These viral oncoproteins bind directly or indirectly to the components of UPS, modifying cellular pathways and suppressor proteins like p53 and pRb. They can also cause progression of malignancy. In this review, we focused on how viral oncoproteins bind to the components of the UPS and how these interactions induce the degradation of cellular proteins for their survival.
Potential Mechanism and Perspectives of Mesenchymal Stem Cell Therapy for Ischemic Stroke: A Review
Authors: Zhu Pengcheng , Tan Hongtu , Gao Haobo , Wang Jiabin , Liu Yangyang , Yang Dongyi , Wu Tao 
Published: September 2024

AbstractMesenchymal stem cells (MSCs), as a stem cell type with multiple differentiation potentials and immune regulatory abilities, have shown broad prospects in the treatment of ischemic stroke in recent years. The main characteristics of MSCs include their self-renewal ability, differentiation potential for different types of cells, and the ability to secrete various bioactive factors such as cytokines, chemokines, and growth factors, which play a key role in tissue repair and regeneration. In the treatment of ischemic stroke, MSCs exert therapeutic effects through various mechanisms, including promoting vascular regeneration of damaged brain tissue, reducing inflammatory responses, and protecting neurons from damage caused by apoptosis. Research have shown that MSCs can promote the repair of ischemic areas by releasing neurotrophic factors and angiogenic factors, while inhibiting immune responses triggered by ischemia, thereby improving neurological function. With the in-depth study of its biological mechanism, MSCs have gradually shown good safety and effectiveness in clinical applications. Therefore, fully exploring and utilizing the potential of MSCs in the treatment of ischemic stroke may provide new ideas and solutions for future neural repair and regenerative medicine.
Higher memory effects and the post-Newtonian calculation of their gravitational-wave signals
Authors: Siddhant S , Grant Alexander M , Nichols David A 
Published: September 2024

Abstract
A new hierarchy of lasting gravitational-wave effects (the higher memory effects) was recently identified in asymptotically flat spacetimes, with the better-known displacement, spin, and center-of-mass memory effects included as the lowest two orders in the set of these effects. These gravitational-wave observables are determined by a set of temporal moments of the news tensor, which describes gravitational radiation from an isolated source. The moments of the news can be expressed in terms of changes in charge-like expressions and integrals over retarded time of flux-like terms, some of which vanish in the absence of radiation. In this paper, we compute expressions for the flux-like contributions to the moments of the news in terms of a set of multipoles that characterize the gravitational-wave strain. We also identify a part of the strain that gives rise to these moments of the news. In the context of post-Newtonian theory, we show that the strain related to the moments of the news is responsible for the many nonlinear, instantaneous terms and ‘memory’ terms that appear in the post-Newtonian expressions for the radiative multipole moments of the strain. We also apply our results to compute the leading post-Newtonian expressions for the moments of the news and the corresponding strains that are generated during the inspiral of compact binary sources. These results provide a new viewpoint on the waveforms computed from the multipolar post-Minkowski formalism, and they could be used to assess the detection prospects of this new class of higher memory effects.
3D reconstruction and volume measurement of irregular objects based on RGB-D camera
Authors: Zhu Yu , Cao Songxiao , Song Tao , Xu Zhipeng , Jiang Qing 
Published: September 2024

Abstract
To address the challenge of measuring volumes of irregular objects, this paper proposes a volume measurement method based on 3D point cloud reconstruction. The point clouds of the object with multiple angles are obtained from an RGB-D camera mounted on a robotic arm, and then are reconstructed to form a whole complete point cloud to calculate the volume of the object. Firstly, the robotic arm is controlled to move to four angles for capturing the original point clouds of the target. Then, by using the rotation and translation matrices obtained from the calibration block pre-registration, the point clouds data from the four angles are fused and reconstructed. Subsequently, the issue of missing bottom point cloud data is addressed using a bottom-filling algorithm. Following this, the efficiency of the point cloud volume calculation algorithm is enhanced through the application of axis-aligned bounding box filtering. Finally, the reconstructed point cloud volume is calculated using a slicing algorithm that integrates 2D point cloud segmentation and point cloud sorting. Experimental results show that this method achieves a volume measurement accuracy of over 95% for irregular objects and exhibits good robustness.
Effect of current probe location on response law of shielded multi-core wire
Authors: Sun Jiangning , Lu Xinfu , Li Xiaopeng , Lyu Xuxu , Wan Haojiang , Wei Guanghui , Pan Xiaodong 
Published: September 2024

Abstract
Bulk current injection (BCI) is a commonly used method in electromagnetic compatibility testing. In order to enhance the injection efficiency of the current probe, the interference process into the internal core wire is analyzed. Theoretical calculations indicate that the shielded multi-core wire exhibits a frequency-selective response under BCI conditions. The peak of the terminal load response voltage occurs at frequencies corresponding to the integral multiples of half the relative length of the cable. The position of the current probe along the cable only affects the amplitude of the distributed current on the shielding layer, but not its distribution pattern. The response of the internal core wire at the resonant frequencies is positively correlated with the distribution pattern of the distributed current on the shielding layer. The probe position has a significant effect on the magnitude of the wire-to-terminal response. Placing the current probe at both ends of the cable results in high injection efficiency and significant power savings.
A new approach for GNSS spoofing detection using power and signal quality monitoring
Authors: Zhang Linjie , Wang Lu , Wu Renbiao , Zhuang Xuebin 
Published: September 2024

Abstract
Global navigation satellite system signals are highly susceptible to spoofing attacks. Signal quality monitoring (SQM) methods are simple and easy to detect spoofing. However, traditional SQM methods are only effective for matched-power cases and exhibit high detection probability only for a short time. This study introduces a new approach, exploiting anomalies in receiver correlation outputs during spoofing. It efficiently detects signal amplitude fluctuations and correlation peak distortions. The Texas Spoofing Test Battery dataset and the real BeiDou spoofing data are used to evaluate the detection performance of the proposed approach. The results show that the proposed approach has excellent detection performance in various spoofing cases, including matched-power, overpowered, static, and dynamic cases. This approach surpasses traditional SQM metrics in detection probability and sensitivity to spoofing stages. Importantly, the proposed approach detects spoofing early.
Study of a novel capacitive pressure sensor using spiral comb electrodes
Authors: Chen Wenjie , Yang Qi , Liu Qi , Zhang Yiqun , He Liang , Xia Yuanlin , Wang Zhuqing , Xia Cao , Huang Yubo 
Published: September 2024

Abstract
For traditional capacitive pressure sensors, high nonlinearity and poor sensitivity greatly limited their sensing applications. Hence, an innovative design of capacitors based on spiral comb electrodes is proposed for high-sensitivity pressure detection in this work. Compared to traditional capacitive pressure sensors with straight plate comb electrodes, the proposed sensor with the spiral comb electrodes increases the overlap areas of electrodes sufficiently, the pressure sensitivity can thus be greatly improved. Moreover, the capacitance variation of the proposed sensor is dominated by the change of the overlap area of the electrodes rather than the electrode’s distance, the linearity can also thus be improved to higher than 0.99. Theoretical analysis and COMSOL-based finite element simulation have been implemented for principle verification and performance optimization. Simulation results show that the proposed design has a mechanical sensitivity of 1.5 × 10−4 m Pa−1, capacitive sensitivity of 1.10 aF Pa−1, and nonlinear error of 3.63%, respectively, at the pressure range from 0 to 30 kPa. An equivalent experiment has been further carried out for verification. Experimental results also show that both the sensitivity and linearity of capacitive pressure sensors with spiral comb electrodes are higher than those with straight comb electrodes. This work not only provides a new avenue for capacitor design, but also can be applied to high-sensitivity pressure detection.
Building aluminium-air battery on waste paper for DIY learning
Authors: Srivastava Vinit , Dubey Shivam , Thakur Abhay Singh , Vaish Rahul 
Published: September 2024

Abstract
Environmental sustainability and the effective use of renewable resources are critical subjects that need to be integrated into our educational systems through practical, hands-on learning. This paper focuses on the fabrication of aluminium-air batteries using waste materials, providing an innovative and cost-effective DIY approach to energy storage education. Utilizing aluminium from food packaging and graphite from pencils, this study demonstrates the construction and functionality of an aluminium-air battery to run an LED, highlighting its potential applications in educational settings and low-cost energy solutions. The paper aims to inspire the adoption of environmentally friendly practices and enhance students’ understanding of electrochemical energy conversion through accessible and engaging DIY projects.
Consecutive diagnosis of nanosecond pulsed discharge in a coaxial electrode configuration using a quadruple emICCD camera system
Authors: Liu Zhengyan , Hirakawa Yoichi , Yamamoto Kazuto , Ryu Terumasa , Li Jie , Jiang Nan , Namihira Takao , Wang Douyan 
Published: September 2024

Abstract
Understanding the rapid dynamics of the primary streamer is crucial for comprehending the nanosecond pulsed discharge process. To reveal the fast primary streamer process, this study introduces a newly developed quadruple emICCD camera system capable of capturing a sequence of four discharge images in single pulse, coupled with self-customized software for data analysis. A nanosecond pulse power with its FWHM of 10.5 ns was applied to a coaxial reactor, focusing on the dynamics of the primary streamer. Our research clarifies the spatiotemporal variations of the primary streamer’s properties and examines their relation with inner electrode diameter (i.d. 0.2–2.0 mm). Results showed that in a pulse-powered coaxial electrode, there are three stages in the primary streamer process and that i.d. serves as an important factor influencing the formation and propagation of streamers. Interestingly, we found that streamer head velocity, streamer width, and streamer area for individual streamers remain constant prior to streamer channels reaching the outer electrode. Furthermore, we also observed an initial increase followed by a decrease in both streamer head velocity and streamer width with increasing i.d values. This study sheds light on the fundamental properties of the primary streamer during nanosecond pulsed discharge, contributing valuable insights for future plasma applications.
Kagome materials AV3Sb5 (A = K,Rb,Cs): pairing symmetry and pressure-tuning studies
Authors: Zhou Yuwei , Ye Ge , Luo Shuaishuai , Song Yu , Lu Xin , Yuan Huiqiu 
Published: September 2024

Abstract
The vanadium-based kagome metals AV3Sb5 (A = K, Rb, and Cs) host a superconducting ground state that coexists with an unconventional charge density wave (CDW). The CDW state exhibits experimental signatures of chirality, electronic nematicity, and time-reversal-symmetry-breaking, raising the questions whether the superconductivity (SC) in AV3Sb5 may also be unconventional, how SC interplays with CDW, and how the two orders evolve upon tuning. This article reviews studies of the superconducting pairing symmetry, and the tuning of SC and CDW in the AV3Sb5 compounds. Various experimental techniques consistently find that CsV3Sb5 exhibits nodeless SC, which remains robust regardless whether the CDW is present. Under hydrostatic pressure, SC in AV3Sb5 becomes enhanced as the CDW is gradually suppressed, revealing a competition between the two orders. In CsV3Sb5, a new CDW state emerges under pressure that competes more strongly with SC relative to the CDW at ambient pressure, and results in two superconducting domes that coexist with CDW. After the CDW in AV3Sb5 is fully suppressed with hydrostatic pressure, a further increase in pressure leads to a nonmonotonic evolution of the superconducting transition temperature driven by lattice modulations. Thickness is shown to be a powerful tuning parameter in AV3Sb5 thin flakes, revealing the evolution of CDW and SC upon dimensional reduction, and can be combined with hydrostatic pressure to shed light on the interplay between SC and CDW. Based on results reviewed in this article, we discuss outstanding issues to be addressed in the AV3Sb5 systems.
Coherent electron phase-space manipulation by combined elastic and inelastic light-electron scattering
Authors: Kempers S T , van Elk I J M , van Leeuwen K A H , Luiten O J 
Published: September 2024

Abstract
Photon-Induced Near-field Electron Microscopy (PINEM), Kapitza–Dirac (KD) gratings, and ponderomotive phase plates are examples of techniques in which the wave function of an electron in free space is manipulated using light fields: free electron quantum optics (FEQO). These effects are usually treated in separate theoretical frameworks. In this paper we present a unified, two-pronged framework that can be used to describe and numerically evaluate the performance of a number of FEQO-based electron-optical elements. The first part is a combination of existing analytical treatments of light-electron scattering, based on solving a relativistically corrected Schrödinger equation. The theoretical overview covers both second-order contributions to PINEM and the Kapitza–Dirac effect. The second, novel element of the approach is based on electron wavefront reconstruction by evaluating the quantum mechanical phase along a bundle of classical electron trajectories. The quasi-classical (but fully relativistic) approach lends itself to simulating a wide variety of FEQO devices, including the examples mentioned. We apply both approaches to a few specific experimental configurations: mirror-based first-order PINEM, second-order PINEM in very high laser intensity, and Kapitza–Dirac diffraction. The results show excellent agreement between the analytical results and the quasi-classical simulations. Finally, we propose a setup that combines KD and PINEM to allow for simultaneous coherent energy and transverse momentum shaping of an electron beam, and present simulation results thereof.
Relation between photoionisation cross sections and attosecond time delays
Authors: Ji Jia-Bao , Kheifets Anatoli S , Han Meng , Ueda Kiyoshi , Jakob Wörner Hans 
Published: September 2024

Abstract
Determination and interpretation of Wigner-like photoionisation delays is one of the most active fields of attosecond science. Previous results have suggested that large photoionisation delays are associated with structured continua, but a quantitative relation between photoionisation cross sections and time delays has been missing. Here, we derive a Kramers–Kronig-like relation between these quantities and demonstrate its validity for (anti)resonances. This new concept defines a topological analysis, which rationalises the sign of photoionisation delays and thereby sheds new light on a long-standing controversy regarding the sign of the photoionisation delay near the Ar 3s Cooper minimum. Our work bridges traditional photoionisation spectroscopy with attosecond chronoscopy and offers new methods for analysing and interpreting photoionisation delays.
Inferring galaxy cluster masses from cosmic microwave background lensing with neural simulation based inference
Authors: Baxter Eric J. , Pandey Shivam 
Published: September 2024

Abstract
Gravitational lensing by massive galaxy clusters distorts the observed cosmic microwave background (CMB) on arcminute scales, and these distortions carry information about cluster masses. Standard approaches to extracting cluster mass constraints from the CMB cluster lensing signal are either sub-optimal, ignore important physical or observational effects, are computationally intractable, or require additional work to turn the lensing measurements into constraints on cluster masses. We apply simulation based inference (SBI) using neural likelihood models to the problem. We show that in circumstances where the exact likelihood can be computed, the SBI constraints on cluster masses are in agreement with the exact likelihood, demonstrating that the SBI constraints are close to optimal. In scenarios where the exact likelihood cannot be feasibly computed, SBI still recovers unbiased estimates of individual cluster masses and combined constraints from multiple clusters. SBI will be a powerful tool for constraining the masses of galaxy clusters detected by future cosmic surveys. Code to run the analyses presented here will be made publicly available.
Inflating in perturbative LVS: global embedding and robustness
Authors: Bera Swagata , Chakraborty Dibya , Leontaris George K. , Shukla Pramod 
Published: September 2024

Abstract
The perturbative LARGE volume scenario (LVS) is a promising moduli stabilisation scheme in which the overall volume modulus of the compactifying Calabi-Yau (CY) threefold is dynamically stabilised to exponentially large values via using only perturbative corrections. In this article, using an orientifold of a K3-fibred CY threefold, we present the global embedding of an inflationary model proposed in the framework of perturbative LVS, in which the overall volume modulus acts as the inflaton field rolling on a nearly flat potential induced by a combination of the α
'3-corrections and the so-called log-loop effects. Given that having a concrete global construction facilitates explicit expressions for a set of sub-leading corrections, as a next step, we present a detailed analysis investigating the robustness of the single-field inflationary model against such corrections, in particular those arising from the winding-type string loop corrections and the higher derivative F4-corrections.
In-silico study on cumulative effects of degeneration and anterior circumferential annular tear on the L5-S1 spinal unit
Authors: Vinyas  , Bhat Subraya Krishna , Yamada Hiroshi , Shyamasunder Bhat N 
Published: September 2024

Abstract
Low back pain is a serious health concern prevalent in majority of the people around the world, especially in case of the elderly. The root cause for this is mostly observed to be the development of lesions/ tears complemented by degenerative effects in the intervertebral disc of L4-L5 and L5-S1 segments. This study aims to analyse the effects of disc degeneration and tears on the mechanical responses of the L5-S1 spinal unit, which has not been investigated. The annulus is represented by an anisotropic hyperelastic Gasser-Ogden-Holzapfel (GOH) model wherein the effect of degeneration is defined by varying the constants responsible for the behaviour of the material in different strain-ranges. A systematic approach is proposed for modelling the effects of disc degeneration in the annulus. Further, the commonly found anterior circumferential tear is modelled to understand its combined effects with degeneration of the annulus. The damaging effect of the tear was limited only to extension movement, causing critical stress variations in its vicinity. However, degeneration had a significant influence on both stress and range of motion of the spinal unit across all types of movements. This study highlights the complex relationship of the physiological movements with pathogenesis of tear and degeneration leading to discogenic pain thus enabling clinicians to develop conservative treatment strategies for specific age groups.
Comparative Effectiveness of the Revised American Joint Committee on Cancer Staging System
Authors: Kao Chia-Wen , Chiang Chun-Ju , Lee Wen-Chung 
Published: September 2024

Abstract
The American Joint Committee on Cancer (AJCC) staging manual is periodically updated. This study aims to examine the staging performances in delineating stage-specific survival curves and to evaluate the reclassification of cases based on the 7th and 8th AJCC editions in Taiwan. Data were sourced from the Taiwan Cancer Registry for cases diagnosed in 2017 (7th edition) and 2018 (8th edition), each with a 2-year follow-up period. Performance was assessed using the area under the receiver operating characteristic curve and the Lorenz curve-derived Gini index, along with 2-year survival rates for evaluating patient prognoses. The 8th edition showed superior staging in four specific cancer types. Oropharyngeal cancer exhibited more variable 2-year survival rates across stages, and liver cancer showed a clearer decline in survival rates with advancing stages. The 8th edition also improved prognostic staging for non-small cell lung cancer and reclassified 26.4% of stage 4 prostate cancer patients under the 7th edition into stages 3 or 4A, showing 2-year survival rates above 90%. Our study highlights the 8th edition’s refined capacity for stage-specific survival distinctions and reclassification of cases to enhance prognostication in certain cancers within Taiwan. We recommend a comprehensive evaluation when adopting a new edition or version.
A normal paradox
Authors: Rosenblatt Lucas 
Published: September 2024

Abstract:
For the past 40 years, Neil Tennant has defended a proof-theoretic criterion of self-referential paradoxicality. According to this criterion, the defining characteristic of paradoxes is that, when formulated within a natural deduction system, they produce derivations that cannot be normalized. This paper raises doubts about Tennant’s approach. Recently, Tennant has suggested that Russell’s paradox might not truly fit his criterion. I will argue that the reasoning that rules out Russell’s paradox can similarly be applied to some semantic paradoxes. Therefore, if Tennant’s assessment of Russell’s paradox holds, few cases may genuinely qualify as paradoxes by his standards.