bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modulation of transforming growth factor-β/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders
Authors: Pervin Shehla , Singh Vineeta , Tucker Alexandria , Collazo Javier , Singh Rajan 
Published: September 2017

AbstractObesity is a major risk factor for the development of diabetes, insulin resistance, dyslipidemia, cardiovascular disease and other related metabolic conditions. Obesity develops from perturbations in overall cellular bioenergetics when energy intake chronically exceeds total energy expenditure. Lifestyle interventions based on reducing total energy uptake and increasing activities including exercise have proved ineffective in the prevention and treatment of obesity because of poor adherence to such interventions for an extended period of time. Brown adipose tissue (BAT) has an extraordinary metabolic capacity to burn excess stored energy and holds great promise in combating obesity and related diseases. This unique ability to nullify the effects of extra energy intake of these specialized tissues has provided attractive perspectives for the therapeutic potential of BAT in humans. Browning of white adipose tissue by promoting the expression and activity of key mitochondrial uncoupling protein 1 (UCP1) represents an exciting new strategy to combat obesity via enhanced energy dissipation. Members of the transforming growth factor-beta (TGF-β) superfamily including myostatin and follistatin have recently been demonstrated to play a key role in regulating white adipose browning both in
A pragmatic analysis of L2 Spanish requests: Acquisition in three situational contexts during short-term study abroad
Authors: Czerwionka Lori , Cuza Alejandro 
Published: September 2017

AbstractThis study examines pragmatic acquisition of requests for English-speaking learners of Spanish. This research expands upon previous work by investigating the acquisition of second language requests during a short-term immersion program (6 weeks) in Madrid, Spain and in three situational contexts: food and drink, general merchandise, and familial. Data were collected using an experimental computerized oral discourse completion task. Requests made by learners (501 requests) and native speakers (224 requests) were compared considering personal deictic orientation and directness of the requests. For learners, shifts from speaker-oriented to hearer-oriented requests indicated greater pragmatic development in food and drink and familial contexts. Results are discussed considering pragmatic developmental stages and differential results in the three contexts.
A socio-cognitive approach to pragmatic inference
Authors: Jiang Wangqi 
Published: September 2017

AbstractThe dominant trend in contemporary pragmatics has been information-biased, focusing on how information is transmitted from speaker to hearer, while the social and cultural side of communication has not been given the attention it deserves for effective communication. To redress the balance, this paper will expose the problems caused by the bias in information-based principles of Horn and Levinson, first taking the interpretation of
Covariation between temporal interlanguage features and nonverbal event categorisation
Authors: Vanek Norbert , Selinker Larry 
Published: September 2017

AbstractThis study tests how patterns of temporal reference in the linguistic expression of advanced Chinese learners of English co-vary with their nonverbal event categorisation. 42 learners were asked to retell videos with achievement-type events and activities in English. Results from expression showed pronounced crosslinguistic influence in learners’ infrequent combination of ongoingness with achievements, when compared with the English controls. Categorisation data signals that L1-modulated preferences also underlie learners’ nonverbal judgements. Crucially, the main new finding is covariation between the frequency of combined forms in learners’ retellings and how close their overall categorisation choices are to the target control group’s.
Paradigm shift: cognitive surgery
Authors: Kenngott Hannes G. , Apitz Martin , Wagner Martin , Preukschas Anas A. , Speidel Stefanie , Müller-Stich Beat Peter 
Published: September 2017

AbstractIn the last hundred years surgery has experienced a dramatic increase of scientific knowledge and innovation. The need to consider best available evidence and to apply technical innovations, such as minimally invasive approaches, challenges the surgeon both intellectually and manually. In order to overcome this challenge, computer scientists and surgeons within the interdisciplinary field of “cognitive surgery” explore and innovate new ways of data processing and management. This article gives a general overview of the topic and outlines selected pre-, intra- and postoperative applications. It explores the possibilities of new intelligent devices and software across the entire treatment process of patients ending in the consideration of an “Intelligent Hospital” or “Hospital 4.0”, in which the borders between IT infrastructures, medical devices, medical personnel and patients are bridged by technology. Thereby, the “Hospital 4.0” is an intelligent system, which gives the right information, at the right time, at the right place to the individual stakeholder and thereby helps to decrease complications and improve clinical processes as well as patient outcome.
Surgical data processing for smart intraoperative assistance systems
Authors: Stauder Ralf , Ostler Daniel , Vogel Thomas , Wilhelm Dirk , Koller Sebastian , Kranzfelder Michael , Navab Nassir 
Published: September 2017

AbstractDifferent components of the newly defined field of surgical data science have been under research at our groups for more than a decade now. In this paper, we describe our sensor-driven approaches to workflow recognition without the need for explicit models, and our current aim is to apply this knowledge to enable context-aware surgical assistance systems, such as a unified surgical display and robotic assistance systems. The methods we evaluated over time include dynamic time warping, hidden Markov models, random forests, and recently deep neural networks, specifically convolutional neural networks.
Possible modulation of PPAR-γ cascade against depression caused by neuropathic pain in rats
Authors: Garg Shanky , Deshmukh Vishwajit Ravindra , Prasoon Pranav 
Published: September 2017

Abstract

Background:
Sciatic nerve ligation causes neuropathic pain with chronic constriction injury (CCI). However, there is no published report on the effect of pioglitazone as an antidepressant in the treatment of depression induced by neuropathic pain with CCI in rats. The aim of this study was to evaluate the effect of pioglitazone as an antidepressant by targeting oxidative stress by the peripheral neuropathic pain model using the CCI of the sciatic nerve.

Methods:
Behavioral studies were carried out to measure thermal hyperalgesia and cold allodynia as markers of neuropathic pain and force swim test for depression. These were followed by estimation of biochemical parameters which include lipid peroxidation (LPO), reduced glutathione, catalase, nitrite and superoxide dismutase (SOD) in the rat brains as a measure of oxidative stress. We administered two intraperitoneal doses of pioglitazone (4.5 and 9.0 mg/kg, i.p.) to the treated group for 28 consecutive days from the day of injury and behavioral as well as biochemical evaluations were performed.

Results:
The results suggested that the administration of pioglitazone significantly countered the neuropathic pain induced depression as interpreted through elevated pain threshold of tactile allodynia and thermal hyperalgesia followed by decreased immobility time in the 9.0 mg/kg dose group.

Conclusions:
It may be concluded that the oxidative stress plays a critical role in the pathogenesis of neuropathic pain and depression as evidenced by the behavioral studies and the changes in the levels of lipid peroxidase, nitrite, catalase, and glutathione and SOD.
Antidiabetic potential of polyphenolic-rich fraction of Tamarindus indica seed coat in alloxan-induced diabetic rats
Authors: Bhadoriya Santosh Singh , Ganeshpurkar Aditya , Bhadoriya Ravi Pratap Singh , Sahu Sanjeev Kumar , Patel Jay Ram 
Published: September 2017

Abstract

Background:

Tamarindus is a monotypic genus and belongs to the subfamily Caesalpinioideae of the family Leguminosae (Fabaceae), Tamarindus indica L., commonly known as Tamarind tree is one of the most important multipurpose tropical fruit tree species in the India, Sudan, Nigeria, Bangladesh and entire subcontinent.

Methods:
Hydroethanolic seed coat extract of Tamarindus indica (HETI) was assessed for presence of phytoconstituents and selection of optimum dose through acute and sub acute toxicity study. The single and multidose (14 days) study were conducted to evaluate antidiabetic potential of HETI in alloxan induced rats via determine of blood glucose level, body weight, hematological profile, extra-pancreatic glucose utilization of isolated rat hemi-diaphragm as well as histopathology of rat pancreas.

Results:
Phytochemical analysis of HETI showed the presence of polyphenol like flavonoids. Single and multidose of HETI significantly (p<0.05; p<0.001) reduced blood glucose level in normoglycaemic, glucose loaded and alloxan induced hyperglycaemic animals. HETI exerts the protective effect on pancreatic β-cells as per results obtained from histopathology of animals. Moreover, HETI increased glucose uptake in isolated rat hemi-diaphragm and prevents decrease in body weight along with recovery of altered hematological parameters.

Conclusions:
The study revealed that HETI have potent hypoglycaemic action by virtue of its phytoconstituents and it can be used as a herbal medicine for diabetes.
The National Capabilities for Animal Response in Emergencies (NCARE) Study: An Assessment of US States and Counties
Authors: Spain C. Victor , Green R.C. , Davis Lacie , Miller Gregory S. , Britt Susan 
Published: September 2017

AbstractCommunities with well-developed animal response plans, along with trained and equipped animal response teams, are typically better able to protect resident livestock and companion animals during a disaster, with fewer animals lost, higher human evacuation compliance rates, and a greater percentage of pets staying with their families. The NCARE Study is a cross-sectional descriptive survey designed to assess, among US states and counties, the level of preparedness for managing animals in an emergency. Overall, 65% of participating states (31/48) reported having a State Animal Response Team (SART), while 48% (16/33) of counties with >1 million population (large counties) and 23% (131/565) of a random sample of counties with <1 million population (small counties) reported having a County Animal Response Team (CART). Only 50% of small counties reported having plans for collocated or cohabitational emergency shelters, compared to 73% of states and 80% of large counties. In stratified analyses, the proportion of counties with a CART ranged from 2% in FEMA Region X to 69% in Region II. Our results demonstrate that many regions of the US have taken some important initial steps towards establishing the capabilities necessary for managing animals in a disaster, while other regions have areas for improvement.
Global Research Trends of Intuitionistic Fuzzy Set: A Bibliometric Analysis
Authors: He Xiaorong , Wu Yingyu 
Published: September 2017

Abstract
Despite the fast growth of intuitionistic fuzzy publications, only a small part of these groundbreaking researches have significantly impacted the field. The main purpose of this paper was to identify and investigate the 100 most cited publications in the intuitionistic fuzzy field. Topic search based on the keyword “intuitionistic fuzzy” in the Science Citation Index and Social Sciences Citation Index databases was conducted to identify the 100 most cited articles. Bibliometric analysis methods were employed to describe these articles from different angles, such as the citation amount and rate, distribution among journals, institutions and countries/regions, author frequency, and citation distribution over time. This paper provides an insight on the characteristics of the highly cited intuitionistic fuzzy publications. The achievements of this study may provide useful information for researchers in the fields related to intuitionistic fuzzy.
Fieldwork Monitoring for the European Social Survey: An illustration with Belgium and the Czech Republic in Round 7
Authors: Vandenplas Caroline , Loosveldt Geert , Beullens Koen 
Published: September 2017

Abstract
Adaptive and responsive survey designs rely on monitoring indicators based on paradata. This process can better inform fieldwork management if the indicators are paired with a benchmark, which relies on empirical information collected in the first phase of the fieldwork or, for repeated or longitudinal surveys, in previous rounds or waves. We propose the “fieldwork power” (fieldwork production per time unit) as an indicator for monitoring, and we simulate this for the European Social Survey (ESS) Round 7 in Belgium and in the Czech Republic. We operationalize the fieldwork power as the weekly number of completed interviews and of contacts, the ratio of the number of completed interviews to the number of contact attempts and to the number of refusals. We use a repeated measurement multilevel model, with surveys in the previous rounds of the European Social Survey as the macro level and the weekly fieldwork power as repeated measurements to create benchmarks. We also monitor effort and data quality metrics. The results show how problems in the fieldwork evolution can be detected by monitoring the fieldwork power and by comparing it with the benchmarks. The analysis also proves helpful regarding post-survey fieldwork evaluation, and links effort, productivity, and data quality.
Responsive Survey Designs for Reducing Nonresponse Bias
Authors: Brick J. Michael , Tourangeau Roger 
Published: September 2017

Abstract
Survey researchers have been investigating alternative approaches to reduce data collection costs while mitigating the risk of nonresponse bias or to produce more accurate estimates within the same budget. Responsive or adaptive design has been suggested as one means for doing this. Falling survey response rates and the need to find effective ways of implementing responsive design has focused attention on the relationship between response rates and nonresponse bias. In our article, we re-examine the data compiled by Groves and Peytcheva (2008) in their influential article and show there is an important between-study component of variance in addition to the within-study variance highlighted in the original analysis. We also show that theory implies that raising response rates can help reduce the nonresponse bias on average across the estimates within a study. We then propose a typology of response propensity models that help explain the empirical findings, including the relative weak relationship between nonresponse rates and nonresponse bias. Using these results, we explore when responsive design tools such as switching modes, giving monetary incentives, and increasing the level of effort are likely to be effective. We conclude with some comments on the use of responsive design and weighting to control nonresponse bias.
Using Response Propensity Models to Improve the Quality of Response Data in Longitudinal Studies
Authors: Plewis Ian , Shlomo Natalie 
Published: September 2017

Abstract
We review two approaches for improving the response in longitudinal (birth cohort) studies based on response propensity models: strategies for sample maintenance in longitudinal studies and improving the representativeness of the respondents over time through interventions. Based on estimated response propensities, we examine the effectiveness of different re-issuing strategies using Representativity Indicators (R-indicators). We also combine information from the Receiver Operating Characteristic (ROC) curve with a cost function to determine an optimal cut point for the propensity not to respond in order to target interventions efficiently at cases least likely to respond. We use the first four waves of the UK Millennium Cohort Study to illustrate these methods. Our results suggest that it is worth re-issuing to the field nonresponding cases from previous waves although re-issuing refusals might not be the best use of resources. Adapting the sample to target subgroups for re-issuing from wave to wave will improve the representativeness of response. However, in situations where discrimination between respondents and nonrespondents is not strong, it is doubtful whether specific interventions to reduce nonresponse will be cost effective.
The Implications of Alternative Allocation Criteria in Adaptive Design for Panel Surveys
Authors: Kaminska Olena , Lynn Peter 
Published: September 2017

Abstract
Adaptive survey designs can be used to allocate sample elements to alternative data collection protocols in order to achieve a desired balance between some quality measure and survey costs. We compare four alternative methods for allocating sample elements to one of two data collection protocols. The methods differ in terms of the quality measure that they aim to optimize: response rate, R-indicator, coefficient of variation of the participation propensities, or effective sample size. Costs are also compared for a range of sample sizes. The data collection protocols considered are CAPI single-mode and web-CAPI sequential mixed-mode. We use data from a large experiment with random allocation to one of these two protocols. For each allocation method we predict outcomes in terms of several quality measures and costs. Although allocating the whole sample to single-mode CAPI produces a higher response rate than allocating the whole sample to the mixed-mode protocol, we find that two of the targeted allocations achieve a better response rate than single-mode CAPI at a lower cost. We also find that all four of the targeted designs out-perform both single-protocol designs in terms of representativity and effective sample size. For all but the smallest sample sizes, the adaptive designs bring cost savings relative to CAPI-only, though these are fairly modest in magnitude.
Investigating Adaptive Nonresponse Follow-up Strategies for Small Businesses through Embedded Experiments
Authors: Thompson Katherine Jenny , Kaputa Stephen J. 
Published: September 2017

Abstract
The U.S. Census Bureau is investigating adaptive Nonresponse Follow-Up (NRFU) strategies for single unit businesses in the 2017 Economic Census. These collection protocols require a suite of viable alternative procedures that can be implemented. With business surveys, the majority of cognitive research and nonresponse follow-up procedures focus on collection methods that obtain valid response data from the larger businesses, and there is relatively little quantitative or qualitative research for small businesses. Moreover, the contact methods for small businesses are often constrained by budget limitations. Business programs at the U.S. Census Bureau rely on mailed reminder letters and supplemental promotional materials, with options for certified and bulk mailings. To explore the benefits and disadvantages of the proposed alternative nonresponse follow-up procedures for small businesses, we conducted a field experiment embedded in the 2014 Annual Survey of Manufactures, an annual program that has similar data collection procedures and sampling units as the Economic Census. This article describes the study and presents the results, then discusses how the recommended nonresponse follow-up procedures are implemented in an adaptive collection design test presently being conducted in the 2015 Annual Survey of Manufactures.
Type 3 renal tubular acidosis associated with growth hormone deficiency
Authors: Liew Yin Ping , Rogers Timothy A. , Garb Jane L. , Allen Holley F. , Reiter Edward O. , Campfield Thomas J. , Dharnidharka Vikas R. , Braden Gregory L. 
Published: September 2017

AbstractBackground:We identified two boys with type 3 renal tubular acidosis (RTA) and growth hormone deficiency and we sought to differentiate them from children with classic type 1 distal RTA.Methods:We reviewed all children <6 years of age with RTA referred over a 13-year period and compared the growth response to alkali therapy in these two boys and in 28 children with only type 1 distal RTA.Results:All children with type 1 RTA reached the 5th percentile or higher on CDC growth charts within 2 years of alkali therapy. Their mean height standard deviation score (SDS) improved from −1.4 to −0.6 SDS and their mean mid-parental height (MPH) SDS improved from −0.6 to 0 SDS after 2 years. In contrast, the boys with growth hormone deficiency had a height SDS of −1.4 and −2.4 SDS after 2 years of alkali and the MPH SDS were both −2.6 SDS after 2 years of alkali therapy. Growth hormone therapy accelerated their growth to normal levels and led to long-term correction of RTA.Conclusions:A child with type 1 RTA whose height response after 2 years of alkali therapy is inadequate should undergo provocative growth hormone testing.
Body weight misperception and health-related factors among Iranian children and adolescents: the CASPIAN-V study
Authors: Angoorani Pooneh , Heshmat Ramin , Ejtahed Hanieh-Sadat , Qorbani Mostafa , Motlagh Mohammad Esmaeil , Ziaodini Hasan , Taheri Majzoubeh , Shafiee Gita , Ahadi Zeinab , Aminaee Tahereh , Kelishadi Roya 
Published: September 2017

AbstractBackground:Along with increased prevalence of obesity, body weight misperception has also increased among adolescents. This study aims to evaluate the proportion of weight misperception among Iranian children and adolescents and its association with some health-related factors.Methods:Data were collected from 14,440 Iranian students, aged 7–18 years, who participated in the national school-based surveillance program (CASPIAN-V). The students’ anthropometric indices and blood pressure were measured using standardized methods, and valid questionnaires were used to assess their weight perception, eating patterns, physical activity and sedentary behaviors. According to agreements between the real weight and self-perceived weight status, participants were classified as underestimated, accurate and overestimated weight.Results:The rates of underestimated, accurate and overestimated weight were 30.8%, 40.8% and 28.4%, respectively. In comparison with the accurate-weight group, both the underestimated- and overestimated-weight groups were less likely to have daily consumption of sugar-sweetened beverages (OR: 0.83, 95% CI: 0.74–0.93 and OR: 0.39, 95% CI: 0.34–0.44, respectively), sweets (OR: 0.81, 95% CI: 0.73–0.90 and OR: 0.68, 95% CI: 0.61–0.76, respectively) and salty snacks (OR: 0.78, 95% CI: 0.66–0.92 and OR: 0.30, 95% CI: 0.24–0.38, respectively). In the overestimated-weight group, the odds of daily intake of fast food decreased by 67% and the odds of low physical activity declined by 38% in comparison with the accurate-weight group.Conclusions:Weight misperception had a high prevalence among Iranian children and adolescents and is associated with their dietary patterns and physical activity behaviors. Suitable education programs need to be developed to correct the children and adolescents’ insight about their weight status.