bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcriptomic Analysis Identifies Candidate Genes and Gene Sets Controlling the Response of Porcine Peripheral Blood Mononuclear Cells to Poly I:C Stimulation
Authors: Wang Jiying , Wang Yanping , Wang Huaizhong , Wang Haifei , Liu Jian-Feng , Wu Ying , Guo Jianfeng 
Published: March 2016

Abstract
Polyinosinic-polycytidylic acid (poly I:C), a synthetic dsRNA analog, has been demonstrated to have stimulatory effects similar to viral dsRNA. To gain deep knowledge of the host transcriptional response of pigs to poly I:C stimulation, in the present study, we cultured and stimulated peripheral blood mononuclear cells (PBMC) of piglets of one Chinese indigenous breed (Dapulian) and one modern commercial breed (Landrace) with poly I:C, and compared their transcriptional profiling using RNA-sequencing (RNA-seq). Our results indicated that poly I:C stimulation can elicit significantly differentially expressed (DE) genes in Dapulian (g = 290) as well as Landrace (g = 85). We also performed gene set analysis using the Gene Set Enrichment Analysis (GSEA) package, and identified some significantly enriched gene sets in Dapulian (g = 18) and Landrace (g = 21). Most of the shared DE genes and gene sets were immune-related, and may play crucial rules in the immune response of poly I:C stimulation. In addition, we detected large sets of significantly DE genes and enriched gene sets when comparing the gene expression profile between the two breeds, including control and poly I:C stimulation groups. Besides immune-related functions, some of the DE genes and gene sets between the two breeds were involved in development and growth of various tissues, which may be correlated with the different characteristics of the two breeds. The DE genes and gene sets detected herein provide crucial information towards understanding the immune regulation of antiviral responses, and the molecular mechanisms of different genetic resistance to viral infection, in modern and indigenous pigs.
Chicken gga-miR-103-3p Targets CCNE1 and TFDP2 and Inhibits MDCC-MSB1 Cell Migration
Authors: Han Bo , Lian Ling , Li Xin , Zhao Chunfang , Qu Lujiang , Liu Changjun , Song Jiuzhou , Yang Ning 
Published: March 2016

Abstract
Marek’s disease (MD) is a highly contagious viral neoplastic disease caused by Marek’s disease virus (MDV), which can lead to huge economic losses in the poultry industry. Recently, microRNAs (miRNAs) have been found in various cancers and tumors. In recent years, 994 mature miRNAs have been identified through deep sequencing in chickens, but only a few miRNAs have been investigated further in terms of their function. Previously, gga-miR-103-3p was found downregulated in MDV-infected samples by using Solexa deep sequencing. In this study, we further verified the expression of gga-miR-103-3p among MDV-infected spleen, MD lymphoma from liver, noninfected spleen, and noninfected liver, by qPCR. The results showed that the expression of gga-miR-103-3p was decreased in MDV-infected tissues, which was consistent with our previous study. Furthermore, two target genes of gga-miR-103-3p, cyclin E1 (CCNE1) and transcription factor Dp-2 (E2F dimerization partner 2) (TFDP2), were predicted and validated by luciferase reporter assay, qPCR, and western blot analysis. The results suggested that CCNE1 and TFDP2 are direct targets of gga-miR-103-3p in chickens. Subsequent cell proliferation and migration assay showed that gga-miR-103-3p suppressed MDCC-MSB1 migration, but did not obviously modulate MDCC-MSB1 cell proliferation. In conclusion, gga-miR-103-3p targets the CCNE1 and TFDP2 genes, and suppresses cell migration, which indicates that it might play an important role in MD tumor transformation.
Rebound Growth of Infantile Hemangiomas After Propranolol Therapy
Authors: Shah Sonal D. , Baselga Eulalia , McCuaig Catherine , Pope Elena , Coulie Julien , Boon Laurence M. , Garzon Maria C. , Haggstrom Anita N. , Adams Denise , Drolet Beth A. , Newell Brandon D. , Powell Julie , García-Romero Maria Teresa , Chute Carol , Roe Esther , Siegel Dawn H. , Grimes Barbara , Frieden Ilona J. 
Published: March 2016

BACKGROUND AND OBJECTIVES:
Propranolol is first-line therapy for problematic infantile hemangiomas (IHs). Rebound growth after propranolol discontinuation is noted in 19% to 25% of patients. Predictive factors for rebound are not completely understood and may alter the management approach. The goal of the study was to describe a cohort of patients with IHs treated with propranolol and to identify predictors for rebound growth.

METHODS:
A multicenter retrospective cohort study was conducted in patients with IHs treated with propranolol. Patient demographic characteristics, IH characteristics, and specifics of propranolol therapy were obtained. Episodes of rebound growth were recorded. Patients’ responses to propranolol were evaluated through a visual analog scale.

RESULTS:
A total of 997 patients were enrolled. The incidence of rebound growth was 231 of 912 patients (25.3%). Mean age at initial rebound was 17.1 months. The odds of rebound among those who discontinued therapy at &lt;9 months was 2.4 (odds ratio [OR]: 2.4; 95% confidence interval [CI]: 1.3 to 4.5; P = .004) compared with those who discontinued therapy between 12 to 15 months of life. Female gender, location on head and neck, segmental pattern, and deep or mixed skin involvement were associated with rebound on univariate analysis. With multivariate analysis, only deep IHs (OR: 3.3; 95% CI: 1.9 to 6.0; P &lt; .001) and female gender (OR: 1.7; 95% CI: 1.1 to 2.6; P = .03) were associated. Of those with rebound growth, 83% required therapeutic modification including 62% of patients with modifications in their propranolol therapy.

CONCLUSIONS:
Rebound growth occurred in 25% of patients, requiring modification of systemic therapy in 15%. Predictive factors for rebound growth included age of discontinuation, deep IH component, and female gender. Patients with these predictive factors may require a prolonged course of therapy.
Influence of intrinsic and extrinsic conditions on the tribological characteristics of diamond-like carbon coatings: A review
Authors: Zahid Rehan , Masjuki Haji Hassan , Varman Mahendra , Kalam Muhammad Abul , Mufti Riaz Ahmad , Mohd Zulkifli Nurin Wahidah Binti , Gulzar Mubashir , Nor Azman Siti Safiyah Binti 
Published: March 2016

Abstract
NEUTRONIC PERFORMANCE OF (U, Pu)C FUEL IN A LATTICE OF GFR USING SCALE 6.0
Authors: Macedo A. A. P. , Velasquez Carlos E. , da Silva C. A. M. , Pereira C. 
Published: March 2016

ABSTRACTThis paper studies the performance of (U, Pu)C fuel in a hexagonal assembly of a GFR (Gas Fast Reactor). The SCALE 6.0 (Standardized Computer Analysis for Licensing Evaluation version 6.0) code was used in the calculation. The goal is to evaluate the behavior of the infinite multiplication factor (kinf) for a heterogeneous assembly model using four nuclear data libraries: V6-238, V7-238, ENDF/B-VI.8 and ENDF/B-VII.0. The burnup of (U, Pu)C was performed by the TRITON-6 module, and the isotopic concentrations were evaluated during the cycle. The present work comprises calculations at Zero Power and Full Power condition. This study intends to achieve more information about different Fast Reactors.
Application of Laser Capture Microdissection to Craniofacial Biology: Characterization of Anatomically Relevant Gene Expression in Normal and Craniosynostotic Rabbit Sutures
Authors: Rottgers S. Alex , Gallo Phillip , Gilbert James , Macisaac Zoe , Cray James , Smith Darren M. , Mooney Mark P. , Losee Joseph , Kathju Sandeep , Cooper Gregory 
Published: March 2016

Objective Fusion of the cranial sutures is thought to depend on signaling among perisutural tissues. Mapping regional variations in gene expression would improve current models of craniosynostosis. Laser capture microdissection (LCM) isolates discrete cell populations for gene expression analysis. LCM has rarely been used in the study of mineralized tissue. This study sought to evaluate the potential use of LCM for mapping of regional gene expression within the cranial suture. Design Coronal sutures were isolated from 10-day-old wild-type and craniosynostotic (CS) New Zealand White rabbits, and LCM was used to isolate RNA from the sutural ligament (SL), osteogenic fronts (OF), dura mater, and periosteum. Relative expression levels for Fibroblast Growth Factor 2 (FGF2), Fibroblast Growth Factor Receptor 2 (FGFR2), Transforming Growth Factor Beta 2 (TGFβ-2), Transforming Growth Factor Beta 3 (TGFβ-3), Bone Morphogenetic Protein 2 (BMP-2), Bone Morphogenetic Protein 4 (BMP-4), and Noggin were determined using quantitative real-time PCR. Results A fivefold increase in TGFβ2 expression was detected in the CS SL relative to wild type, whereas 152-fold less TGFβ-3 was detected within the OF of CS animals. Noggin expression was increased by 10-fold within the CS SL, but reduced by 13-fold within the CS dura. Reduced expression of FGF2 was observed within the CS SL and dura, whereas increased expression of FGFR2 was observed within the CS SL. Reduced expression of BMP-2 was observed in the CS periosteum, and elevated expression of BMP-4 was observed in the CS SL and dura. Conclusions LCM provides an effective tool for measuring regional variations in cranial suture gene expression. More precise measurements of regional gene expression with LCM may facilitate efforts to correlate gene expression with suture morphogenesis and pathophysiology.
CUIDADOS DE ENFERMAGEM NA RESSONÂNCIA MAGNÉTICA CARDÍACA
Authors: Vieira Dias Washington Luiz , Pitangueira Barros Thomas 
Published: March 2016

A ressonância magnética cardíaca é um método diagnóstico que fornece informação morfofuncional em uma vasta gama de patologias do sistema cardiovascular. Por ser um exame complexo, de várias fases, torna-se relevante o papel da enfermagem na ressonância magnética cardíaca. O presente estudo tem como objetivo demonstrar as atribuições da equipe de enfermagem nos exames de ressonância magnética cardíaca como forma de garantir uma assistência específica e segura ao paciente. A metodologia utilizada foi uma revisão integrativa de caráter exploratório e do tipo descritivo utilizando as bases de dados científicos LILACS, SCIELO, MEDLINE, BDENF e PUBMED, extraindo periódicos publicados recentemente disponíveis na íntegra em português e inglês. Como conclusão o enfermeiro desempenha um papel fundamental em garantir a qualidade da assistência e a segurança do paciente em todos os aspectos relacionados ao exame de ressonância magnética cardiovascular.
SISTEMATIZAÇÃO DA ASSISTÊNCIA DE ENFERMAGEM: DESAFIOS PARA A IMPLANTAÇÃO
Authors: Marinelli Natália Pereira , Silva Allynne Rosane Almeida , Silva Déborah Nayane Oliveira 
Published: March 2016

O objetivo desse trabalho é analisar as dificuldades encontradas para a sua execução, a fim de modificar e conscientizar a equipe de enfermagem envolvida no processo de cuidar sobre a necessidade de implantar a SAE em todos os serviços de saúde. Foram acionadas as bases de dados Lilacs, Medline, BDENF e encontrados 26 artigos e 16 livros sobre o tema, tendo como critérios para a busca as palavras obstáculos, ou desafios à implantação da sistematização da assistência de enfermagem. Na análise desses artigos, percebeu-se que a finalidade de implantar a sistematização da assistência de enfermagem visa a organização do cuidado a partir de um método sistemático. Dessa forma, a SAE apresenta-se como um desafio, o que indica a necessidade de novas investigações para que ocorra o aprimoramento contínuo da prática de enfermagem.
The United Nations Convention on the Rights of Persons with Disabilities: From the Perspective of Young People
Authors: Quigley (Editor) Nolan , Kamara Mohamed Saidu , Gangadhar Yellamma , Paybeyee Daintowon D , Chandralal Ranjana 
Published: March 2016

This article presents the views of four young disabled people from Sierra Leone, India, Liberia and Sri Lanka regarding what the UN Convention on the Rights of Persons with Disabilities means to them and the experiences that they had in promoting the Convention. All of the four contributors are involved in Leonard Cheshire Disability's Young Voices project. This project was initiated by Leonard Cheshire Disability during the negotiation of the UN Convention, which enabled disabled people from developing countries to make a direct contribution to the negotiation process, including attending the Ad Hoc Committee meeting in New York. The long-term objective of the Young Voices project is to nurture and develop the skill of young disabled people in developing countries to become the future leaders of the disability movement. The project is now embarking on its second stage, with disabled people receiving training on how to effectively lobby their Governments to sign and ratify the UN Convention as well as working with the media (including film making) in their own countries to raise the political profile of disability issues. Eighteen (18) young disabled people, one from each of the participating countries involved in Young Voices project, attended the conference jointly hosted by Leonard Cheshire Disability and the United Nations Economic Commission for Africa, that took place in Addis Ababa, Ethiopia, 19th - 22nd May 2008. Further information regarding the conference can be found at http://www.lcint.org/?lid=4048
Visually Experiencing a Phone Call: The Calculated Consumer Labor Deaf People Perform to Gain Access through Video Relay Service
Authors: Brunson Jeremy 
Published: March 2016

Feminist scholars have suggested a broader conceptualization of work to include paid and unpaid, visible and invisible labor. Employing this broader conceptualization, this paper examines a new form of service delivery for deaf people, video relay service, as an example of the growing trend in the United States that shifts labor from the service provider to service recipient. The data discussed in this paper were collected from two focus groups with deaf people who shared their experiences with and feelings about video relay service. The findings suggest that although video relay service is preferred to text relay service by deaf people, there are still misunderstandings that occur. And, in responding to those misunderstandings, deaf people must determine whether it is worth their time and energy to confront less than adequate sign language interpreters, hang up and call back in order to get another interpreter, or do nothing.
We Exist: Intersectional In/Visibility in Bisexuality & Disability
Authors: Caldwell Kate 
Published: March 2016

The intersection of theories of disability and bisexuality is unexplored, yet both are identities rendered in/visible by paternalistic environments where individual and political identities are defined by oppositional binaries and vulnerable to compulsory citizenship. The development of such identities can be better understood by using a bisexual approach to inform theories of disability and a disability approach to inform theories of sexuality inclusive of bisexuality. Common themes that emerge center around issues of choice, fluidity of identity, the phenomena of “coming out” and “passing,” and limitations to citizenship attendant to in/visible identities. Disability studies can provide a non-normative discursive space within which such identity issues may be addressed critically. Further, this article hopes to interject a bisexual perspective in discussions concerning applications of queer theory in disability studies.
Wrestling with Group Identity: Disability Activism and Direct Funding
Authors: Kelly Christine 
Published: March 2016

With disability representing a diverse array of experiences and identities, it seems unlikely that advocacy groups would be able to agree on concrete policy issues. And yet, there does appear to be consensus in the global North on a number of topics. This paper explores one such example, advocacy around direct funding models of care in order to ask the question: What are the implications for the collective identity of a social movement when groups coalesce around very particular issues? I uncover the implicit identity underlying direct funding advocacy, and how mobilizing around this identity has lead to substantial success in terms of instituting direct funding programs. However, the identity does not ‘disappear’ when the programs are actualized, leading to the exclusion and marginalization of many individuals from both specific programs and social movements. This collective identity has significant consequences for disability movements in the global North, how disability is defined and at times it results in conservative political demands. This paper suggests that a ‘collective of individuals’ approach to conceptualizing and enacting social movements represented by Titchkosky (2003) and Do-It-Yourself feminism may hold potential for future disability activism.
(Re)Creating a World in Seven Days: Place, Disability and Salvation in Extreme Makeover: Home Edition
Authors: Askew Emily 
Published: March 2016

At its most superficial rhetorical level, ABC’s hit television show, Extreme Makeover: Home Edition, equates the condition of the family home with the condition of the bodies inside the home. If the home is ‘fixed’, then the people who live in that home will be 'fixed', as well. In this essay, I consider the ways that Extreme Makover: Home Edition constructs the human body as disabled through the medium of architecture, helped along by reality television’s version of Christian sacrificial atonement.
Citizenship in Name Only: Constructing Meaningful Citizenship through a Recalibration of the Values Attached to Waged Labor
Authors: MacGregor Marion 
Published: March 2016

In November 2010 the Toronto Star reported that the newly revamped Canadian citizenship test had led to an unusually high failure rate. Using the generally, although not universally, accepted understanding of citizenship as a set of civil, political and social rights and responsibilities the more meaningful test is how, or whether, we can exercise our citizenship. Closer examination reveals a deeply rooted connection between the ability to exercise social citizenship and participation in waged labor. Denied access to waged labor, as people with disabilities systematically are, undermines a person’s identity as an active citizen and his or her ability to exercise social citizenship. A recalibration of the values associated with waged labor namely, independence, self-reliance and productivity would extend worth and identity to those systemically deprived of both, produce allies amongst historically disadvantaged groups, and benefit broader segments of society many of who grow disenchanted with the current distribution of wealth and power. Key Words: waged labor, productivity, independence, social citizenship, meaningful citizenship
'No Rights without Responsibilities': Disability Rights and Neoliberal Reform under New Labour
Authors: Owen Randall , Harris Sarah Parker 
Published: March 2016

The New Labour government in the United Kingdom led a series of welfare reforms for people with disabilities from 1997 to 2010. These reforms were heavily influenced by neoliberalism, and emphasized that there were 'no rights without responsibilities, 'making labor market participation essential. Simultaneously, the recognition of disability rights was growing in the United Kingdom, culminating in the ratification of the United Nations Convention on the Rights of Persons with Disabilities in 2009. This article explores the tension between neoliberalism and the human rights approach to disability in the context of New Labour’s welfare reforms for people with disabilities. The analysis includes the perspectives of people with disabilities and disability stakeholders who participated in focus groups or interviews in an English metropolitan region, and is framed by the principles that underpin the Convention. The article offers policy insights to ensure that the rights of people with disabilities are included in future welfare reforms.Key Words: conditionality, employment, welfare-to-work, workfare, United Kingdom
Coming to Claim Crip: Disidentification with/in Disability Studies
Authors: Schalk Sami 
Published: March 2016

This creative-critical paper combines creative non-fiction and theory to trace one non-disabled scholar’s personal experience with disability studies as a field and a community. Using disidentification and crip theory, this paper theorizes the personal, political, and academic utility of identifying with crip as a nondisabled, fat, black, queer, female academic. This crip identification then undergirds and informs the researcher’s scholarship in and relationship to disability studies as a field. Specifically referencing the Society for Disability Studies dance as a potential space of cross-identification, this paper suggests that disidentification among/across/between minoritarian subjects allows for coalitional theory and politics between disability studies and other fields, particularly race/ethnic and queer/sexuality studies. Keywords: crip, identity, queer theory, race
"This is the anthropologist, and she is sighted": Ethnographic Research with Blind Women
Authors: Hammer Gili 
Published: March 2016

Power relations and the researcher's gaze are extremely relevant to the research of blind people, yet rarely documented. Based on three years of anthropological research with blind women in Israel, this paper discusses the methodological considerations raised by the ethnography of blindness and the position of a sighted-woman-researcher in the field. Employing a "reflexive interpretation," the analysis explores the ways in which research with blind participants raises specific questions regarding researcher-researched power relations and social interactions, offering a fresh approach to the discussion of the researcher's "gaze" and knowledge gathered in the field. Focusing on sight and blindness within the research process, the article addresses "sensory knowledge" raised in the field, offering a nuanced account of the ethnographic inquiry as a sensory endeavor, promoting a dialogue among disability studies, anthropology of the senses, feminist disability studies, and qualitative methodology. Key words: blindness; ethnographic research; anthropology; senses; Israel; visual culture; disability; power relations.
Emphasizing Observation in a Gallery Program for Blind and Low-Vision Visitors: Art Beyond Sight at the Museum of Fine Arts, Houston
Authors: Hoyt Bridget O'Brien 
Published: March 2016

The article recreates a gallery conversation with blind and low-vision visitors focused on The Judgment of Solomon, (c. 1640) by Matthias Stomer. Rather than passively receiving the interpretations of the facilitator, participants work together to build an understanding of the painting as a whole from the details described. The article goes on to give a history of the program's development including a nuanced evaluation of the merits of handling objects as an aid to comprehension.Key words: Museum access for the blind and visually impaired, Museum of Fine Arts, Houston, art education for the blind, verbal descriptions of visual art. Audio description of visual art, guided description.
An Art History & Art Making Course for Blind Adults
Authors: Thoma Street 
Published: March 2016

The manager of the Philadelphia Museum of Arts accessible programs gives a history of the institution’s services for people with disabilities, with particular attention to services for the blind and visually impaired. These include descriptive tours, touch tours, three-dimensional tactile interpretations of two-dimensional works, and a long standing art history and art making class for blind and visually impaired students, Form in Art. Key words:Philadelphia Museum of Art, museum accessibility, touch tours, descriptive tours, audio description, blind artists, art education for the blind and visually impaired.