bluuebunny/crossref_metadata_2025_split huggingface dataset:
Standard language ideology and multilingualism: Results from a survey among European students
Authors: Vogl Ulrike 
Published: September 2017

Abstract
This article draws upon data from 1880 students across Europe, gathered through an online survey. It aims at identifying general trends regarding their beliefs about multilingualism: Are these still shaped by the dominant standard language ideology (SLI)? In the article, results from factor analysis that examined underlying dimensions of beliefs about multilingualism and language learning are presented. These dimensions are evaluated differently by subsamples of students. On the one hand, students are divided by national backgrounds; for instance, Central European students differ from Belgian students. On the other hand, variables such as geographical mobility play an equal role: Students who consider moving to another country differ in their beliefs from their peers who prefer to stay in their home countries.
Influence of rare-earth metal on the zinc oxide nanostructures: application in the photocatalytic degradation of methylene blue and p-nitro phenol
Authors: Labhane Prakash K. , Sonawane Gunvant H. , Sonawane Shirish H. 
Published: September 2017

Abstract
Rare-earth cerium (Ce)-doped zinc oxide (ZnO) spherical nanoparticles were synthesized by using the co-precipitation method. The doped materials were characterized by means of the X-ray diffraction, Williamson-Hall Plot, and field emission scanning electron microscopy analyses. The prepared nanoparticles exhibit a hexagonal wurtzite structure as observed from the XRD measurements. Energy dispersive X-ray spectroscopy data confirmed the purity of the prepared samples. The photocatalytic activity of the rare-earth Ce-doped ZnO spherical nanoparticles was investigated through the degradation of methylene blue (MB) and p-nitrophenol (PNP) solution under UV light radiation. Among the different amounts of dopant, 5 mole% Ce-doped ZnO nanoparticles showed the highest degradation with UV light radiation for both MB dye and PNP solution. The particle size, morphology, and separation of the photo-induced electron–hole pair are the main factors that influence photocatalytic activity. The probable mechanisms of photocatalytic degradation and mineralization of MB and PNP are also explained by liquid chromatography–mass spectrometry analysis.
One-pot, three-component, selective synthesis of the polyfunctionalized 4H-pyran and 4H-benzo[b]pyran derivatives in the presence of a highly efficient molecular sieve-supported zinc catalyst
Authors: Magyar Ágnes , Hell Zoltán 
Published: September 2017

Abstract
A series of pentasubstituted 4H-pyrans and tetrahydrobenzo[b]pyrans are synthesized with excellent yields via a one-pot condensation of aromatic aldehydes, malononitrile, and a dicarbonyl compound, ethyl acetoacetate, acetyl-acetone or dimedone, in the presence of 4 Å molecular sieve modified with zinc(II) as heterogeneous catalyst, in ethanol. The process offers numerous advantages, such as better yield, short reaction time, and mild reaction conditions. The catalyst’s preparation is simple and it could be reused while still maintaining its activity.
Spectrophotometric and quantum-chemical study of acid-base and complexing properties of (±)-taxifolin in aqueous solution
Authors: Lutoshkin Maxim A. , Kuznetsov Boris N. , Levdansky Vladimir A. 
Published: September 2017

Abstract
This study reports the acid-base properties of taxifolin (Tf) in HCl media and aqueous complexation with Ni(II). The equilibrium processes was investigated using a spectrophotometric technique and ab initio calculations. Equilibrium constant of protonation was determined using a non-linear Cox-Yates method. Analysis of Ni(II)-Tf complex species under metal dominance conditions was performed in tris-buffer solution. For interpretation and verification of experimental results the Def2-SVP/DFT/PBE0/SMD level was used.
Implementation in nursing and midwifery. A scoping review / Implementationsprojekte in der Pflege und Hebammenarbeit. Scoping review
Authors: Loytved Christine Anna Lieselotte , Hasenberg Gabriele , Brendel Karin , Bothe-Moser Cornelia , Eggenschwiler Ruth , Eigenmann Denise , Graf Petra , Hammer Kristin , Hauser Regula , Oberndörfer Katrin , Pfister-Stoppa Anja , Spiegel-Hefel Elisabeth , Stiefel Andrea 
Published: September 2017

Abstract

Background
Evidence-based expertise in nursing and midwifery is growing but is not automatically turned into practice. The importance of implementation research is therefore increasing. International research results on factors facilitating implementation have not yet been sufficiently presented.

Objective
This scoping review will explore the findings on successful preparation, realisation and maintenance of interventions in nursing and midwifery.

Method
Based on an existing systematic approach, relevant data bases were accessed to identify original studies relating to implementation research in nursing and midwifery. The process of study selection and the characteristics of the included studies were charted.

Findings
In the four reviews and 38 studies which met the inclusion criteria, various factors leading to successful implementation are identified. Based on the included studies, four facilitating factors can be pinpointed: (1) workplace culture (16 entries), (2) leadership culture (28 entries), (3) resources (4 entries), and (4) training (22 entries). Depending on the specific phase of the implementation process (preparation, realisation, or maintenance), these factors will vary in importance.

Conclusion
This scoping review provides an orientation for the field of implementation research and it maps the design, themes and results of the studies included. It should be noted that few studies take into consideration the relevant theories, as well as the influence that the researchers and the target group may have on the implementation process, or provide an exact description of the setting in which the implementation takes place.
Japanese university students’ attitudes towards their English and the possibility of ELF awareness
Authors: Ishikawa Tomokazu 
Published: September 2017

AbstractPrevious studies have identified Japanese negative attitudes towards their English and ambivalent attitudes towards the language (e.g. Jenkins 2007,English as a Lingua Franca: Attitude and identity. Oxford: Oxford University Press; Matsuda 2003, The ownership of English in Japanese secondary schools.World Englishes22(4). 483–496; McKenzie 2010,The social psychology of English as a global language: Attitudes, awareness and identity in the Japanese context. Dordrecht: Springer). The current research targets Japanese university students and adds several insights into the nature of these attitudes through the analysis of 95 open-ended questionnaires and 18 conversational interviews. First of all, the participants’ negative language attitudes embraced notable contradictions. Also, their ambivalence was scarcely evident, and more to the point, a matter of degree. Moreover, it is thedoxicexperience (Bourdieu 1977,Outline of a theory of practice. Trans. Richard Nice. Cambridge: Cambridge University Press) within Japanese society that was likely to hinder grounding those attitudes on their own critical thinking and valuing their English communication ability with non-Japanese. And most importantly, it was easy for them to appreciate English as a Lingua Franca (ELF) perspectives, so long as they would like to use English for international communication. More precisely, while they were unlikely to have any previous attitudes towards the unfamiliar representation of their English (i.e. from ELF perspectives), they were highly likely to develop positive attitudes towards it. This article calls for more future research and effort devoted to raising ELF awareness in Japanese and other similar contexts.
Molecular genetic and clinical delineation of 22 patients with congenital hypogonadotropic hypogonadism
Authors: Aoyama Kohei , Mizuno Haruo , Tanaka Tatsushi , Togawa Takao , Negishi Yutaka , Ohashi Kei , Hori Ikumi , Izawa Masako , Hamajima Takashi , Saitoh Shinji 
Published: September 2017

AbstractBackground:Congenital hypogonadotropic hypogonadism (CHH) is classified as Kallmann syndrome (KS) with anosmia/hyposmia or normosmic (n)CHH. Here, we investigated the genetic causes and phenotype-genotype correlations in Japanese patients with CHH.Methods:We enrolled 22 Japanese patients with CHH from 21 families (18 patients with KS and 4 with nCHH) and analyzed 27 genes implicated in CHH by next-generation and Sanger sequencing.Results:We detected 12 potentially pathogenic mutations in 11 families, with three having a mutation inConclusions:The frequency of CHH genes in the Japanese was compatible with previous reports, except that
PD-L1 expression in squamous-cell carcinoma and adenocarcinoma of the lung
Authors: Janzic Urska , Kern Izidor , Janzic Andrej , Cavka Luka , Cufer Tanja 
Published: September 2017

AbstractBackgroundWith introduction of immunotherapy (IT) into the treatment of advanced non-small-cell lung cancer (NSCLC), a need for predictive biomarker became apparent. Programmed death ligand 1 (PD-L1) protein expression is most widely explored predictive marker for response to IT. We assessed PD-L1 expression in tumor cells (TC) and immune cells (IC) of squamous-cell carcinoma (SCC) and adenocarcinoma (AC) patients.Patients and methodsWe obtained 54 surgically resected tumor specimens and assessed PD-L1 expression by immunohistochemistry after staining them with antibody SP142 (Ventana, USA). Clinicopathological characteristics were acquired from the hospital registry database. Results were analyzed according to cut-off values of ≥ 5% and ≥ 10% of PD-L1 expression on either TC or IC.Results29 (54%) samples were AC and 25 (46%) were SCC. PD-L1 expression was significantly higher in TC of SCC compared to AC at both cut-off values (52% vs. 17%, p = 0.016 and 52% vs. 14%, p = 0.007, respectively) no difference in PD-L1 expression in IC of SCC and AC was found. In AC alone, PD-L1 expression was significantly higher in IC compared to TC at both cut-off values (72% vs. 17%, p < 0.001 and 41% vs. 14%, p = 0.008, respectively), while no significant difference between IC and TC PD-L1 expression was revealed in SCC.ConclusionsOur results suggest a significantly higher PD-L1 expression in TC of SCC compared to AC, regardless of the cut-off value. PD-L1 expression in IC is high in both histological subtypes of NSCLC, and adds significantly to the overall positivity of AC but not SCC.
Toxicological profile of organochlorines aldrin and dieldrin: an Indian perspective
Authors: Sharma Noopur , Garg Deepali , Deb Roumi , Samtani Ratika 
Published: September 2017

AbstractSeveral epidemiological studies have suggested various environmental factors as a possible cause for increased incidence of various abnormalities. Of the various environmental contaminants, the most prevalent and the most discussed are the endocrine disrupting chemicals. Contact of such disruptors with humans has become inevitable today. They are cosmopolitan and present from agriculture to industrial sectors, even in day-to-day consumer products. Aldrin and dieldrin belong to one such class of substances which are known to have a toxic effect on various physiological systems of the human body. Despite an imposed ban on their manufacture and commercial use, these pesticides could still be detected in probable areas of consumption like agriculture. The present review discusses the known possible toxic effects of aldrin and dieldrin and their current existence in the ecosystem across India.
Elevated semaphorin 5A in patients with Hashimoto’s thyroiditis: a case–control study
Authors: Liu Yongping , Wang Shuo , Guo Qingling , Li Yongze , Qin Jing , Zhao Na , Li Yushu , Shan Zhongyan , Teng Weiping 
Published: September 2017

Objective
Hashimoto’s thyroiditis (HT) is characterized by elevated specific auto-antibodies, including TgAb and TPOAb. Increasing evidence has demonstrated the essential role of Th17 cells in HT. However, the underlying mechanism is still unclear. Semaphorin 5A (Sema 5A) is involved in several autoimmune diseases through the regulation of immune cells. The aim of the present study was to explore the role of Sema 5A in HT.

Methods
We measured serum Sema 5A levels in HT (n = 92) and healthy controls (n = 111) by enzyme-linked immunosorbent assay (ELISA). RNA levels of Sema 5A and their receptors (plexin-A1 and plexin-B3), as well as several cytokines (IFN-γ, IL-4 and IL-17), were detected by real-time polymerase chain reaction in peripheral blood mononuclear cells from 23 patients with HT and 31 controls. In addition, we investigated the relationship between serum Sema 5A and HT.

Results
Serum Sema 5A in HT increased significantly compared with healthy controls (P < 0.001). Moreover, serum Sema 5A levels were positively correlated with TgAb (r = 0.511, P < 0.001), TPOAb (r = 0.423, P < 0.001), TSH (r = 0.349, P < 0.001) and IL-17 mRNA expression (r = 0.442, P < 0.001). Increased Sema 5A RNA expression was observed (P = 0.041) in HT compared with controls. In receiver-operating characteristic (ROC) analysis, serum Sema 5A predicted HT with a sensitivity of 79.35% and specificity of 96.40%, and the area under the curve of the ROC curve was 0.836 (95% CI: 0.778–0.884, P < 0.001).

Conclusions
These data demonstrated elevated serum Sema 5A in HT patients for the first time. Serum Sema 5A levels were correlated with thyroid auto-antibodies and IL-17 mRNA expression. Sema 5A may be involved in immune response of HT patients.
Continuous Glucose Monitoring in Very Preterm Infants: A Randomized Controlled Trial
Authors: Galderisi Alfonso , Facchinetti Andrea , Steil Garry M. , Ortiz-Rubio Paulina , Cavallin Francesco , Tamborlane William V. , Baraldi Eugenio , Cobelli Claudio , Trevisanuto Daniele 
Published: September 2017

BACKGROUND AND OBJECTIVES:Impaired glucose control in very preterm infants is associated with increased morbidity, mortality, and poor neurologic outcome. Strategies based on insulin titration have been unsuccessful in achieving euglycemia in absence of an increase in hypoglycemia and mortality. We sought to assess whether glucose administration guided by continuous glucose monitoring (CGM) is more effective than standard of care blood glucose monitoring in maintaining euglycemia in very preterm infants.METHODS:Fifty newborns ≤32 weeks’ gestation or with birth weight ≤1500 g were randomly assigned (1:1) within 48-hours from birth to receive computer-guided glucose infusion rate (GIR) with or without CGM. In the unblinded CGM group, the GIR adjustments were driven by CGM and rate of glucose change, whereas in the blinded CGM group the GIR was adjusted by using standard of care glucometer on the basis of blood glucose determinations. Primary outcome was percentage of time spent in euglycemic range (72–144 mg/dL). Secondary outcomes were percentage of time spent in mild (47–71 mg/dL) and severe (&lt;47 mg/dL) hypoglycemia; percentage of time in mild (145–180 mg/dL) and severe (&gt;180 mg/dL) hyperglycemia; and glucose variability.RESULTS:Neonates in the unblinded CGM group had a greater percentage of time spent in euglycemic range (median, 84% vs 68%, P &lt; .001) and decreased time spent in mild (P = .04) and severe (P = .007) hypoglycemia and in severe hyperglycemia (P = .04) compared with the blinded CGM group. Use of CGM also decreased glycemic variability (SD: 21.6 ± 5.4 mg/dL vs 27 ± 7.2 mg/dL, P = .01; coefficient of variation: 22.8% ± 4.2% vs 27.9% ± 5.0%; P &lt; .001).CONCLUSIONS:CGM-guided glucose titration can successfully increase the time spent in euglycemic range, reduce hypoglycemia, and minimize glycemic variability in preterm infants during the first week of life.
Effect of topically applied hyaluronic acid on pain and palatal epithelial wound healing: An examiner‐masked, randomized, controlled clinical trial
Authors: Yıldırım Selin , Özener Hafize Öztürk , Doğan Başak , Kuru Bahar 
Published: September 2017

AbstractBackgroundThis study aims to evaluate the effects of two different concentrations of topical hyaluronic acid (HA) on postoperative patient discomfort and wound healing of palatal donor sites after free gingival graft (FGG) surgery.
MethodsThirty‐six patients requiring FGG were randomly assigned into three groups in an examiner‐masked, randomized, controlled clinical trial. After harvesting palatal grafts, 0.2% and 0.8% HA gels were used in test groups 1 and 2, respectively. Gels were applied on donor sites and protected with periodontal dressing in the test groups, whereas the wound was covered only with periodontal dressing in the control group. On days 3, 7, 14, and 21, pain and burning sensation were recorded using a visual analog scale (VAS) as well as other parameters such as complete epithelization (CE) and color match on days 3, 7, 14, 21, and 42.ResultsTest groups experienced less pain than the control group on days 3 and 7 (P <0.001 and P <0.001, respectively). Mean VAS score for burning sensation was higher in the control group on day 3 compared with test groups 1 and 2 (P = 0.03 and P = 0.02, respectively). CE in all patients was achieved on day 21 in both test groups, whereas it was achieved on day 42 in the control group. The test groups showed higher color match scores than the control group on days 21 (P <0.001 and P <0.001, respectively) and 42 (P = 0.004 and P = 0.002, respectively).ConclusionTopical application of HA exhibits positive impact on postoperative pain and burning sensation, and accelerates palatal wound healing in terms of epithelization and color match.
Effects of local administration of tiludronic acid on experimental periodontitis in diabetic rats
Authors: Nunes Nara L.T. , Messora Michel R. , Oliveira Luiz Fernando , Lisboa Mario , Garcia Marina Costa Barcellos , Rêgo R.O. , Novaes Arthur Belém , de Souza Sérgio Luís Scombatti , Ervolino Edilson , Furlaneto Flávia A.C. 
Published: September 2017

AbstractBackgroundTiludronic acid (TIL) presents antiresorptive and anti‐inflammatory properties and has not been evaluated in the periodontitis–diabetes mellitus (DM) association to date, to the best knowledge of the authors. This study evaluates effects of local administration of TIL on experimental periodontitis (EP) in rats with streptozotocin‐induced DM.MethodsThirty‐two animals (Rattus norvegicus albinus, Wistar) were divided into groups DM/C (Control), DM/EP, DM/EP/TIL1, and DM/EP/TIL3. In EP groups, a ligature was placed around mandibular first molars. In groups DM/EP/TIL1 and DM/EP/TIL3, TIL solutions (1 and 3 mg/kg, respectively) were injected into the gingival tissue of mandibular molars every other day for 10 days, until euthanasia. Periodontal tissues were analyzed by microcomputed tomography (micro‐CT), histomorphometry, immunohistochemistry (tartrate‐resistant acid phosphatase [TRAP], receptor activator of nuclear factor‐κB ligand [RANKL], osteoprotegerin, cleaved caspase 3), and quantitative reverse transcription‐polymerase chain reaction (interleukin [IL]‐1β, vascular endothelial growth factor [VEGF]).ResultsIn micro‐CT analyses, groups DM/EP/TIL1 and DM/EP/TIL3 presented reduced alveolar bone resorption (P < 0.05). Group DM/EP/TIL3 presented decreased attachment loss (P < 0.05). The amount of TRAP‐positive multinucleated cells was decreased in TIL groups (P < 0.05). Group DM/EP/TIL3 presented a lower immunolabeling pattern for RANKL (P < 0.05). TIL treatment decreased genic expression of IL‐1β, and in group DM/EP/TIL3, expression of VEGF was increased (P < 0.05).ConclusionLocal administration of TIL promoted a protective effect against tissue destruction in EP in diabetic rats, and the dosage of 3 mg/kg of TIL promoted the best results regarding its antiresorptive and anti‐inflammatory effects.
Salivary neuropeptides, stress, and periodontitis
Authors: Haririan Hady , Andrukhov Oleh , Böttcher Michael , Pablik Eleonore , Wimmer Gernot , Moritz Andreas , Rausch‐Fan Xiaohui 
Published: September 2017

AbstractBackgroundScientific evidence for psychologic stress as a risk factor for periodontitis is fragmentary and relies mostly on either questionnaire‐based or biomarker studies. The aim of this study is to investigate brain‐derived neurotrophic factor, substance P, vasoactive intestinal peptide (VIP), neuropeptide Y (NPY), calcitonin gene‐related peptide, and adrenomedullin as well as cortisol in saliva and serum in periodontal health and disease combined with different aspects of stress and possible associations with clinical parameters.MethodsIn total, 56 patients with aggressive and chronic periodontitis and 44 healthy controls were screened by enzyme‐linked immunosorbent assay and mass spectrometry for presence of neuropeptides and cortisol in saliva and serum. Psychologic stress was evaluated by validated questionnaires. All substances were explored for a possible relationship to periodontitis, clinical parameters, and stress.ResultsVIP and NPY showed significantly higher levels in saliva but not in serum of patients with periodontitis. These neuropeptides correlated with the extent, severity, and bleeding on probing scores in patients with periodontitis. Females had significantly lower salivary VIP levels. There were no differences among participants regarding psychologic stress.ConclusionVIP and NPY in saliva could be potential sex‐specific salivary biomarkers for periodontitis regardless of psychologic stress.
Combination of ultrasonic decontamination, soft tissue curettage, and submucosal air polishing with povidone‐iodine application for non‐surgical therapy of peri‐implantitis: 12‐month clinical outcomes
Authors: Stein Jamal M. , Hammächer Christian , Michael Sareh Said‐Yekta 
Published: September 2017

AbstractBackgroundThe aim of this study is to evaluate clinical outcomes of a concept for non‐surgical peri‐implantitis combining stepwise mechanical debridement measures with adjuvant povidone‐iodine application with and without systemic antibiotics.MethodsForty‐five patients with chronic periodontitis and a total of 164 screw‐typed implants with peri‐implantitis were included. Peri‐implantitis was defined as radiographic bone loss of > 2 mm, probing depth (PD) ≥5 mm with bleeding on probing (BOP). Stepwise treatment of implants was performed with ultrasonic debridement, soft tissue curettage (STC), glycine powder air polishing (GPAP), and a repeated submucosal application of povidone‐iodine. Teeth with PD > 4 mm were treated simultaneously according to the same concept except STC. In cases with severe periodontitis (n = 24), amoxicillin and metronidazole (AM) were prescribed for 7 days.ResultsAfter 12 months, implants treated without AM showed significant reductions (P < 0.05) of mean PD (1.4 ± 0.7 mm), clinical attachment level (CAL) (1.3 ± 0.8 mm), and BOP (33.4% ± 17.2%). In deep pockets (PD > 6 mm) changes of mean PD (2.3 ± 1.3 mm), CAL (2.0 ± 1.6 mm), and BOP (44.0% ± 41.7%) were more pronounced. Intake of AM did not significantly influence the changes in these parameters. However, the reduction of implant sites with PD > 4 mm and BOP was significantly higher in patients with AM than in those without AM (31.8% ± 12.6% versus 20.8% ± 14.7%; P < 0.05).ConclusionsThe combination of ultrasonic debridement, STC, and GPAP with adjuvant povidone‐iodine led to significant clinical improvements at implants. Systemic antibiotics had limited effects on the reduction of persisting implant sites with treatment need.