bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endovascular Treatment of Traumatic Carotid Cavernous Fistula with Balloon-Assisted Sinus Coiling
Authors: Andrade Gustavo , De Souza Moysés L. Ponte , Marques Romero , Silva José Laércio , Abath Carlos , Azevedo-Filho Hildo R.C. 
Published: January 2017

This study aimed to propose an alternative treatment for carotid cavernous fistula (CCF) using the balloon-assisted sinus coiling (BASC) technique and to describe this procedure in detail. Under general anesthesia, we performed the BASC procedure to treat five patients with traumatic CCF. Percutaneous access was obtained via the right femoral artery, and a 7F sheath was inserted, or alternatively, a bifemoral 6F approach was accomplished. A microcatheter was inserted into the cavernous sinus over a 0.014-inch microwire through the fistulous point; the microcatheter was placed distal from the fistula point, and a “U-turn” maneuver was performed. Through the same carotid access, a compliant balloon was advanced to cross the point of the fistula and cover the whole carotid tear. Large coils were inserted using the microcatheter in the cavernous sinus. Coils filled the adjacent cavernous sinus, respecting the balloon. Immediate complete angiographic resolution was achieved, and an early angiographic control (mean = 2.6 months) indicated complete stability without recanalization. The clinical follow-up has been uneventful without any recurrence (mean = 15.2 months). An endovascular approach is optimal for direct CCF. Because the detachable balloon has been withdrawn from the market, covered stenting requires antiplatelet therapy and its patency is unconfirmed, but cavernous sinus coiling remains an excellent treatment option. Currently, there is no detailed description of the BASC procedure. We provide detailed angiograms with suitable descriptions of the exact fistula point, and venous drainage pathways. Familiarity with these devices makes this technique effective, easy and safe.
Stent Placement to Treat Ruptured Vertebral Dissecting Aneurysms
Authors: Chen Yong-An , Qu Rong-Bo , Bian Yu-Song , Zhu Wei , Zhang Kun-Peng , Pang Qi 
Published: January 2017

Conventional endovascular treatment may have limitations for vertebral dissecting aneurysm involving the origin of the posterior inferior cerebellar artery (PICA). We report our experiences of treating vertebral dissecting aneurysm with PICA origin involvement by placing a stent from the distal vertebral artery (VA) to the PICA to save the patency of the PICA. Stenting from the distal VA to the PICA was attempted to treat ruptured VA dissecting aneurysm involving the PICA origin with sufficient contralateral VA in eight patients. The procedure was successfully performed in seven patients with one failure because of PICA origin stenosis, which was treated with two overlapping stents. In the seven patients, PICAs had good patency on postoperative angiography and transient lateral brainstem ischemia represents a procedure-related complication. Follow-up angiographies were performed in seven patients and showed recanalization of the distal VA in three patients without evidence of aneurysmal filling. There was no evidence of aneurysm rupture during the follow-up period, and eight patients had favorable outcomes (mRS, 0–1). Placing a stent from the distal VA to the PICA with VA occlusion may present an alternative to conventional endovascular treatment for vertebral dissecting aneurysm with PICA origin involvement with sufficient contralateral VA.
Variability in Evolution and Course of Gunshot Injuries to the Neck and Impact on Management
Authors: Lee Stephen R. , Metwalli Zeyad A. , Yevich Steven M. , Whigham Cliff J. , Benndorf Goetz 
Published: January 2017

This study reports the differences in evolution and course of multiple pseudoaneurysms (PAs) and an axillary arteriovenous fistula (AVF) after penetrating vascular trauma due to shotgun injury to the head and neck. We describe the unusual case of a young man who, following penetrating shotgun injuries to the head and neck, developed multiple PAs of the common carotid, vertebral and superficial temporal arteries as well as an axillary AVF. Serial angiographic follow-up studies documented differences in time of occurrence, evolution and course of these lesions. This allowed for tailored management using endovascular (AVF, superficial temporal artery PAs) and conservative (carotid and vertebral PAs) treatment. No complication occurred and complete cure of all lesions was achieved and documented after seven months. Time of occurrence, evolution and regression of penetrating vascular injuries can differ significantly even in the same patient. Close angiographic follow-up helps not only detect a lesion with delayed occurrence, but also provides a practical basis for decision-making for optimal therapeutic management.
Therapeutic Infiltration of the Facet Joint in Minor Intervertebral Disease
Authors: Longo M. , Blandino A. , Granata F. , Rizzo D. , Vinci S. , Vermiglio M. 
Published: January 2017

A CT-guided infiltration technique of the facet joints was employed on a group of 20 patients suffering from sciatica without any signs of morphostructural alteration of the facet joints, secondary to Minor Intervertebral Disease (MID). The typical flouroscopically guided intra-articular facet arthrography has been substituted by a CT-guided technique that privileges therapy rather than diagnosis. The study involved 20 patients between 29 and 57 years of age (average 44.5), of both sexes (16 females and four males). The average time which elapsed from onset of symptomatology was 9.5 months. At seven days after the first treatment subjective results were considered excellent by 11 patients (55%), good by one (5%) and satisfactory by one (5%). Six out of 20 patients (30%) failed to gain any relief of symptoms. Only one patient (5%) had a worsening of pain. Clinical evaluation by the physician at the same time showed a good result in 11 patients (55%), satisfactory in two (10%). In six patients (30%) the symptomatology was unchanged. At 4 months the subjective results were excellent in three (15%), good in six (30%) and satisfactory in two (10%). Nine (45%) had no positive results. The clinical examination was excellent in two (10%), good in seven (35%), satisfactory in two (10%) and without any relief of symptomatology in nine (45%). These results encourage the use of CT-guided infiltration that, together with the small amount of contrast medium injected into the joint space, make it a safe technique for patients, avoiding or reducing complications.
Dural Arteriovenous Shunts Involving the Sphenoparietal Sinus
Authors: Ezura M. , Takahashi A. , Mizoi K. 
Published: January 2017

A 40-year-old male suffered transient global amnesia and was diagnosed as having a very rare location of dural arteriovenous shunt (dAVS) involving the right sphenoparietal sinus. The feeding pedicles of dAVS were not only arising from the right external carotid system, including the middle meningeal artery, but also the right internal carotid system including the ophthalmic artery. The dAVS drained into the right sphenoparietal sinus, right vein of Labbe, and right basal vein of Rosenthal through numerous dilated temporal cortical veins. The arteriovenous shunt itself was located at the dura around the right superior ophthalmic fissure and a large varix received direct shunting blood flow from the right sphenoparietal sinus. The dAVS was cured by drainer clipping following transarterial embolisations. A dAVS with cortical venous drainage is considered to have a higher risk of haemorrhage and venous infarction than the others and thus warrants treatment even if the clinical symptom is minimal. If the dAVS has a single drainer, it will be easily cured by way of drainer clipping. Preoperative embolisation makes clipping easier and safer. Intraoperative angiography is useful because preoperative angiography may not necessarily show the complete angioarchitecture around the lesion.
Spontaneous Polymerisation of Cyanoacrylate/Lipiodol Mixtures Causing Failed Embolisation
Authors: ApSimon H.T. , Bartlett A. , Phadke R. , Khangure M.S. 
Published: January 2017

In vitro experiments to investigate spontaneous polymerisation of n-butyl-2-cyanoacrylate when mixed with non ionic oily contrast medium are reported. The results suggest an interaction between the mixture components which is unique to one particular batch of Lipiodol Ultrafluid and Histoacryl n butyl cyanoacrylate. The interaction cannot be reproduced with other batches of Lipiodol Ultrafluid nor with an alternative preparation of n-butyl-2-cyanoacrylate. Implications for the use of the materials in neuro-interventional practice are discussed.
Selective Intra-Arterial Thrombolysis for Embolic Complications of Cerebral Endovascular Therapy
Authors: Picard L. , Bracard S. , Maffei L. , Anxionnat R. , Prada E. , Burdin D. , Per A. 
Published: January 2017

Cerebral thrombo-embolic complications seldom occur during intracranial endovascular therapeutic procedures. Yet, despite a systemic preventive regimen of pre-operative intravenous acetylsalicylic acid and effective systemic heparinisation, we encountered seven complications of this type over a period of five years, a 3.7‰ incidence (7/1858). Local intra-arterial thrombolysis performed immediately after the thrombo-embolic complication resulted in complete recanalization in five cases and partial recanalization in two. CT scans performed 24 hours after thrombolysis were normal in six of the seven patients. Only one female patient with partial recanalization showed a limited cortical infarct in the parietal distribution of the middle cerebral artery territory. In all seven cases recanalization of the occluded vessel resulted in a return to the baseline initial neurological status. This short series demonstrates the usefulness of emergent thrombolysis dealing with the thrombo-embolic complications of angiography or endovascular therapy. These results are in agreement with these experimental data showing that early recanalization can prevent macroscopically visible infarcts.
Endovascular Treatment of a Ruptured Intracranial Arterial Aneurysm in a 12-Year-Old Child with Recessive Polycystic Kidney Disease
Authors: De Blasi R. , Lasjaunias P. , Rodesch G. , Alvarez H. 
Published: January 2017

A 12-year-old boy with recessive polycystic kidney disease and congenital hepatic failure, presented intracranial subarachnoid haemorrhage, due to the rupture of a laterobasilar tip aneurysm. In addition, he presented a left-sided middle cerebral unruptured aneurysm demonstrated during the screening procedure. Our patient is a boy, like most children with intracranial aneurysms, but differs from children with intracranial aneurysms in polycystic kidney disease. The age of bleeding was low (actually the second youngest case reported), with a good Hunt and Hess grade at admission. The localization of the aneurysm is exceptionally posterior (laterobasilar tip); in our case as intracranial aneurysms can be multifocal at that age. Renal function and blood pressure were normal. The endovascular GDC approach achieved a good result and excellent clinical outcome. Although most of what is known in this disease belongs to the autosomal dominant form, it is unclear whether the risk of a demonstrated unruptured intracranial aneurysm is the same as the risk of SAH from a non demonstrated one. It even seems that bleeding during follow-up in patients with polycystic kidney disease mostly occurs from non previously demonstrated intracranial aneurysms9.
Hand hygiene among healthcare workers: A qualitative meta summary using the GRADE-CERQual process
Authors: Chatfield Sheryl L. , DeBois Kristen , Nolan Rachael , Crawford Hannah , Hallam Jeffrey S. 
Published: January 2017

Background: Hand hygiene is considered an effective and potentially modifiable infection control behaviour among healthcare workers (HCW). Several meta-studies have been published that compare quantitatively expressed findings, but limited efforts have been made to synthesise qualitative research. Objectives: This paper provides the first report of integrated findings from qualitative research reports on hand hygiene compliance among HCW worldwide that employs the GRADE-CERQual process of quality assessment. Methods: We conducted database searches and identified 36 reports in which authors conducted qualitative or mixed methods research on hand hygiene compliance among HCW. We used Dedoose analysis software to facilitate extraction of relevant excerpts. We applied the GRADE-CERQual process to describe relative confidence as high, moderate or low for nine aggregate findings. Findings: Highest confidence findings included that HCW believe they have access to adequate training, and that management and resource support are sometimes lacking. Individual, subjective criteria also influence hand hygiene. Discussion: These results suggest the need for further investigation into healthcare cultures that are perceived as supportive for infection control. Surveillance processes have potential, especially if information is perceived by HCW as timely and relevant.
A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells
Authors: Zahn Malena , Marienfeld Ralf , Melzner Ingo , Heinrich Janine , Renner Benjamin , Wegener Silke , Mießner Anna , Barth Thomas F. E. , Dorsch Karola , Brüderlein Silke , Möller Peter 
Published: January 2017

Key PointsA novel PTP1B variant, PTP1BΔ6, is expressed in cHL cell lines and tumor samples. PTP1BΔ6 augments JAK/STAT activity, cell proliferation, and survival in cHL cell lines.
Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin
Authors: Hayashi Toshiyuki , Fukui Tomoyasu , Nakanishi Noriko , Yamamoto Saki , Tomoyasu Masako , Osamura Anna , Ohara Makoto , Yamamoto Takeshi , Ito Yasuki , Hirano Tsutomu 
Published: January 2017

Abstract
Background
The sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been reported to increase both low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol (C). This study aimed to determine how SGLT-2 inhibitors affect LDL and HDL-C subspecies.

Methods
This single center, open-label, randomized, prospective study included 80 patients with type 2 diabetes taking prescribed oral hypoglycemic agents. Patients were allocated to receive dapagliflozin (n = 40) or sitagliptin (n = 40) as add-on treatment. Fasting blood samples were collected before and 12 weeks after this intervention. Small dense (sd) LDL-C, large buoyant (lb) LDL-C, HDL2-C, and HDL3-C levels were determined using our established homogeneous assays. Statistical comparison of blood parameters before and after treatment was performed using the paired t test.

Results
Dapagliflozin and sitagliptin comparably decreased HbA1c (0.75 and 0.63%, respectively). Dapagliflozin significantly decreased body weight, systolic blood pressure, plasma triglycerides and liver transaminases, and increased adiponectin; sitagliptin did not alter these measurements. LDL-C and apolipoprotein (apo) B were not significantly changed by dapagliflozin, whereas HDL-C and apo AI were increased. Dapagliflozin did not alter concentrations of LDL-C, but sd LDL-C decreased by 20% and lb LDL-C increased by 18%. Marked elevation in lb LDL-C (53%) was observed in individuals (n = 20) whose LDL-C was elevated by dapagliflozin. However, sd LDL-C remained suppressed (20%). Dapagliflozin increased HDL2-C by 18% without affecting HDL3-C. Sitagliptin did not alter plasma lipids or lipoprotein subspecies.

Conclusions
A SGLT-2 inhibitor, dapagliflozin suppresses potent atherogenic sd LDL-C and increased HDL2-C, a favorable cardiometabolic marker. Although LDL-C levels are elevated by treatment with dapagliflozin, this was due to increased concentrations of the less atherogenic lb LDL-C. However, these findings were not observed after treatment with dipeptidyl peptidase-4 inhibitor, sitagliptin.
Trial registration UMIN Clinical Trials Registry (UMIN000020984)
Metabolic plasticity for subcutaneous fat accumulation in a long distance migratory bird traced by 2H2O
Authors: Viegas Ivan , Araújo Pedro M. , Rocha Afonso D. , Villegas Auxiliadora , Jones John G. , Ramos Jaime A. , Masero José A. , Alves José A. 
Published: January 2017

The migrant black-tailed godwit (Limosa limosa) traditionally used natural wetlands in the Iberian Peninsula preparing for migratory flights by feeding mainly in estuaries. In recent decades this species has become increasingly dependent on rice fields, thereby relying on a plant-based diet for fueling. Dietary fatty acids (FA) seem to be determinant to the composition of accumulated subcutaneous fat in migratory birds. It is still unclear whether metabolic plasticity allows for modification and/or synthesis of FA, contributing for a lipid profile that enables a successful migratory performance.
Deuterated water was administered to captive black-tailed godwits submitted to two diets (fly larvae vs. rice) and the incorporation of deuterium (2H) into subcutaneous triglycerides was analysed by NMR. A recently developed localized biopsy method for sampling subcutaneous fat was employed with ulterior successful release of all birds into the wild. The average chemical structure reflected mostly a mixture of saturated and monounsaturated 16- and 18-carbon FA, a profile frequently found in migrant birds. Significantly higher levels of polyunsaturated FA, as well as detectable levels of n-3 FA were observed in fly larvae-fed birds. Excess 2H-enrichments in FA revealed significantly higher rates of fractional de novo lipogenesis and FA desaturation capacity in rice-fed birds.
This novel and non-lethal tracer method revealed the capacity of this species to alter its lipid metabolism to compensate for a poorer dietary lipid contribution. Due to its versatility, adapting this method to other scenarios and/or other migratory species is considered feasible and cost-effective.
A inserção de tópicos de astronomia no ensino médio utilizando o processo da descoberta através de observações astronômicas
Authors: Gurgel Walldiney Pedra , Gester Rodrigo Do Monte 
Published: January 2017

Neste trabalho apresentamos uma metodologia pedagógica baseada na teoria de ensino de Bruner, que permite ao professor inserir tópicos de astronomia no ensino médio baseado em observações astronômicas efetuadas pelos próprios alunos, com a utilização de softwares astronômicos, binóculos e telescópios. A temática do trabalho justifica se pelo fato dos PCN+ abordarem o tema estruturador Universo, Terra e Vida, que é composto pelas unidades temáticas: Terra e sistema solar, O universo e sua origem e Compreensão humana do Universo. Essas três unidades temáticas nada mais são do que tópicos elementares de astronomia no ensino médio, que são temas pouco explorados em livros didáticos de física disponíveis em nossas escolas. A metodologia consistiu em apresentar aos alunos o prazer da observação do céu noturno com o auxílio de softwares astronômicos que permitem aos discentes identificar constelações e astros no céu. Essas observações foram feitas primeiramente a olho nu, e depois utilizando binóculos e telescópios, indo das observações mais simples às mais complexas, como sugere a teoria de ensino de Bruner, utilizando a aprendizagem por descobertas. Após as observações é montado um plano de ensino baseado nas constelações, estrelas e planetas que mais chamaram a atenção dos alunos.
Semilinear fractional order integro-differential inclusions with infinite delay
Authors: Aissani Khalida , Benchohra Mouffak , Darwish Mohamed Abdalla 
Published: January 2017

Abstract
In this paper, we study the existence of mild solutions for a class of semilinear fractional order integro-differential inclusions with infinite delay in Banach spaces. Sufficient conditions for
the existence of solutions are derived by using a nonlinear alternative of
Leray–Schauder type for multivalued maps due to Martelli. An example is given to illustrate the theory.
Exercise-induced effects on UCP1 expression in classical brown adipose tissue: a systematic review
Authors: Flouris Andreas D. , Dinas Petros C. , Valente Angelica , Andrade Cláudia Marlise Balbinotti , Kawashita Nair Honda , Sakellariou Paraskevi 
Published: January 2017

AbstractUnderstanding the impact of regular exercise training on uncoupling protein 1 (UCP1) activity in classical brown adipose tissue (
An Approach to Detect Vehicles in Multiple Climatic Conditions Using the Corner Point Approach
Authors: Anandhalli Mallikarjun , Baligar Vishwanath P. 
Published: January 2017

Abstract
This paper presents a new method of detecting vehicles by using a simple and effective algorithm. The features of a vehicle are the most important aspects in detection of vehicles. The corner points are considered for the proposed algorithm. A large number of points are densely packed within the area of a vehicle, and the points are calculated by using the Harris corner detector. Making use of the fact that they are densely packed, grouping of these points is carried out. This grouping indicates that the group of corners belongs to each vehicle, and such groupings play a vital role in the algorithm. Once grouping is done, the next step is to eliminate the background noise. The Lucas-Kande algorithm is used to track the extracted corner points. Each corner point of the vehicle is tracked to make the output stable and reliable. The proposed algorithm is new, detect vehicles in multiple conditions, and also works for complex environments.
Utilization of Co-occurrence Pattern Mining with Optimal Fuzzy Classifier for Web Page Personalization
Authors: Srinivasa Rao Pappu , Vasumathi Devara 
Published: January 2017

AbstractSeveral users use metasearch engines directly or indirectly to access and gather data from more than one data source. The effectiveness of a metasearch engine is majorly determined by the quality of the results it returns in response to user queries. The rank aggregation methods that have been proposed until now exploit a very limited set of parameters, such as total number of used resources and the rankings they achieved from each individual resource. In this paper, we use the fuzzy-bat to merge the score computation module effectively. Initially, we give a query to different search engines we use and the topnlist from each search engine is chosen for further processing our technique. We then merge the topnlist based on unique links, and we do some parameter calculations such as title-based calculation, snippet-based calculation, content-based calculation, address-based calculation, link-based calculation, uniform resource locator-based calculation, and co-occurrence-based calculation. We give the solutions of the calculations with the user given the ranking of links to the fuzzy-bat to train the system. The system then ranks and merges the links we obtain from different search engines for the query we give.