bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Stereodivergent Carbamate Synthesis by Selective in situ Trapping of Organic Carbonate Intermediates.
Authors: Guo Wusheng , Laserna Victor , Martin Eddy , Escudero‐Adan Eduardo C. , Kleij Arjan W. 
Published: May 2016

AbstractTrans carbamates are prepared in a diastereoselective approach by a judicious one‐pot combination of organic carbonates, prepared in situ, and suitable amine reagents under appropriate reaction conditions.
ChemInform Abstract: Palladium‐Catalyzed Decarboxylative Alkoxycarbonylation of Potassium Aryltrifluoroborates with Potassium Oxalate Monoesters.
Authors: Miao Jinmin , Fang Ping , Jagdeep Sahota , Ge Haibo 
Published: May 2016

AbstractA radical‐mediated Pd(II)/Pd(IV) catalytic cycle is proposed.
ChemInform Abstract: Direct Use of Benzylic Alcohols for Gold(III)‐Catalyzed S‐Benzylation of Mercaptobenzoic Acids in Water.
Authors: Hikawa Hidemasa , Tada Ayaka , Kikkawa Shoko , Azumaya Isao 
Published: May 2016

AbstractA gold(III)‐catalyzed direct substitution of benzylic alcohols in water is presented.
ChemInform Abstract: Palladium Supported on Modified Magnetic Nanoparticles: A Phosphine‐Free and Heterogeneous Catalyst for Suzuki and Stille Reactions.
Authors: Ghorbani‐Choghamarani Arash , Norouzi Masoomeh 
Published: May 2016

AbstractThe catalyst can be easily recovered from the reaction mixture and is reused with no loss of its activity.
ChemInform Abstract: Copper‐Mediated Arylation with Arylboronic Acids: Facile and Modular Synthesis of Triarylmethanes
Authors: Rao H. Surya Prakash , Rao A. Veera Bhadra 
Published: May 2016

AbstractDifferent triarylmethanes are obtained by a copper(II)‐catalyzed reaction of diarylmethanols with arylboronic acids.
ChemInform Abstract: Catalytic Asymmetric Hetero‐Diels—Alder Reactions of Enones with Isatins to Access Functionalized Spirooxindole Tetrahydropyrans: Scope, Derivatization, and Discovery of Bioactives.
Authors: Cui Hai‐Lei , Chouthaiwale Pandurang V. , Yin Feng , Tanaka Fujie 
Published: May 2016

AbstractA series of spirooxindole tetrahydropyrans (III) and (VIII) is prepared by an organocatalytic asymmetric hetero‐Diels—Alder reaction of isatins with enones.
ChemInform Abstract: Organocatalytic Strategy for the Enantioselective Cycloaddition to Trisubstituted Nitroolefins to Create Spirocyclohexene‐Oxetane Scaffolds.
Authors: Monleon Alicia , Glaus Florian , Vergura Stefania , Joergensen Karl Anker 
Published: May 2016

AbstractAn efficient catalytic system is found for the unprecedented enantioselective cycloaddition of dienals such as (I), (IX), and (XI) to α,β,β‐trisubstituted nitroolefins (II).
ChemInform Abstract: Design, Synthesis and Antitrypanosomal Activities of 2,6‐Disubstituted‐4,5,7‐trifluorobenzothiophenes.
Authors: Bhambra Avninder S. , Edgar Mark , Elsegood Mark R.J. , Li Yuqi , Weaver George W. , Arroo Randolph R.J. , Yardley Vanessa , Burrell‐Saward Hollie , Krystof Vladimir 
Published: May 2016

AbstractNew trifluorobenzothiophene derivatives (IIIb) and (Vb) show significant antitrypanosomal activities against Trypanosoma brucei rhodesiense and no toxicity towards mammalian (MCF7) cells.
ChemInform Abstract: A Selective C—H Insertion/Olefination Protocol for the Synthesis of α‐Methylene‐γ‐butyrolactone Natural Products.
Authors: Lloyd Matthew G. , D'Acunto Mariantonietta , Taylor Richard J. K. , Unsworth William P. 
Published: May 2016

AbstractAn efficient one‐pot procedure is elaborated for the synthesis of a series of α‐methylene‐γ‐butyrolactones, including some natural products such as α‐cyclocostunolide (XIV).
ChemInform Abstract: A Facile One‐Pot Synthesis of 2,3‐Diarylated Benzo[b]furans via Relay NHC and Palladium Catalysis.
Authors: Jia Yanyan , Li Tuanjie , Yu Chenxia , Jiang Bo , Yao Changsheng 
Published: May 2016

AbstractAn alternative approach to 2,3‐diarylated benzofurans (III) by virtue of the sequential catalysis of NHC and Pd from substituted 2′‐bromodiphenylbromomethanes (I) and aryl aldehydes (II) is developed.
ChemInform Abstract: Stereoselective One‐Pot Synthesis of (1Z)‐ and (1E)‐1‐Arylmethylidene‐2,3‐dihydro‐1H‐pyrrolo[1,2‐a]benzimidazoles by Cyclization of Alk‐4‐ynals with O‐Diaminobenzene.
Authors: Gvozdev Valentin D. , Shavrin Konstantin N. , Egorov Mikhail P. , Nefedov Oleg M. 
Published: May 2016

AbstractDepending on the reaction conditions, the cyclization of various alkynals with o‐diaminobenzene (I) yields (E)‐ or (Z)‐compounds (III) or (IV), (VI).
ChemInform Abstract: A Metal‐Free Tandem Ring‐Opening/Ring‐Closing Strategy for the Heterocyclic Conversion of Benzoxazin‐4‐ones to Oxazolines.
Authors: Rajesh Nomula , Manisha Banala , Ranjith Jala , Krishna Palakodety Radha 
Published: May 2016

AbstractThe title strategy features good to excellent reaction yields and mild reaction conditions.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative Synthesis of 2,3‐Disubstituted Chromones.
Authors: Shen Chaoren , Li Wanfang , Yin Hongfei , Spannenberg Anke , Skrydstrup Troels , Wu Xiao‐Feng 
Published: May 2016

AbstractThe reaction sequence starts with a Pd‐catalyzed carbonylation of the ketone with o‐bromofluorobenzene to give vinyl benzoates, which subsequently transform into 1,3‐diketones via a Claisen—Hasse rearrangement.
ChemInform Abstract: Acid Catalyzed Synthesis of 2‐(2‐Aminophenyl)quinazoline‐4‐amine and Reaction with Aromatic Aldehydes.
Authors: Marinho Elina , Proenca M. Fernanda 
Published: May 2016

AbstractTetracyclic dihydroquinazolines are synthesized in high yields from the title amine and aldehydes under both conventional heating and microwave conditions.
ChemInform Abstract: Site Selective Synthesis of Cytotoxic 1,3,6‐Trisubstituted 3,6‐Diunsaturated (3Z,6Z)‐2,5‐Diketopiperazines via a One‐Pot Multicomponent Method.
Authors: Liao Sheng‐Rong , Du Li‐Juan , Qin Xiao‐Chu , Xu Liang , Wang Jun‐Feng , Zhou Xue‐Feng , Tu Zheng‐Chao , Li Juan , Liu Yong‐Hong 
Published: May 2016

AbstractA one‐pot protocol is presented for the reaction of 1,4‐diacetyl‐2,5‐diketopiperazine with a halohydrocarbon and one or two different aldehydes.
ChemInform Abstract: Stereoselective Synthesis of β‐Rhamnopyranosides via Gold(I)‐Catalyzed Glycosylation with 2‐Alkynyl‐4‐nitro‐benzoate Donors
Authors: Zhu Yugen , Shen Zhengnan , Li Wei , Yu Biao 
Published: May 2016

Abstract11 examples
ChemInform Abstract: Schoberine B, an Alkaloid with an Unprecedented Straight C5 Side Chain, and Myriberine B from Myrioneuron faberi.
Authors: Cao Ming‐Ming , Zhang Yu , Peng Zong‐Gen , Jiang Jian‐Dong , Gao Yue‐Jiao , Hao Xiao‐Jiang 
Published: May 2016

AbstractSchoberine B (I) and myriberine B (II) show moderate inhibitory activity against hepatitis C virus in vitro.
ChemInform Abstract: Collective Synthesis and Biological Evaluation of Tryptophan‐Based Dimeric Diketopiperazine Alkaloids.
Authors: Tadano Shinji , Sugimachi Yukihiro , Sumimoto Michinori , Tsukamoto Sachiko , Ishikawa Hayato 
Published: May 2016

AbstractNovel concise syntheses of a series of tryptophan‐based dimeric diketopiperazine alkaloids, such as eurocristatine (IV), WIN 64745, asperdimin, and naseseazine A and B are disclosed.
ChemInform Abstract: Tandem Allylboration‐Prins Reaction for the Rapid Construction of Substituted Tetrahydropyrans: Application to the Total Synthesis of (‐)‐Clavosolide A.
Authors: Millan Alba , Smith James R. , Chen Jack L.‐Y. , Aggarwal Varinder K. 
Published: May 2016

AbstractThe total synthesis of (‐)‐clavosolide A (VIII) is carried out via a three‐component allylboration—Prins reaction of boronic ester (I) with aldehydes (II) and (III) and a lithiation—borylation reaction of intermediate (V) as key steps.
Event space model in virtual and real society based on special field
Authors: Xue Yunlan , Xu Lingyu , Yu Jie , Wang Lei , Zhang Gaowei 
Published: May 2016

SummaryWith the development and popularization of Internet big data, the cyber world nearly parallels to the real world to reflect social hot event. However, the multi‐source and heterogeneity features of reality data lead to incompleteness and unreality based on Internet data. To solve the above issues, we propose Event Space Model (ESM) for event analysis by multi‐viewer. In the model, each event is mapped into Network Public Opinion Data Space (OS) and Actual Behavior Data Space (BS). In addition, we propose an Event Starting Point Discovery Algorithm (ESPDA) to effectively detect starting point of event and to identify the representation of event trajectory in OS and BS. The experimental results prove that the ESM represent event from multi‐viewer, while the ESPDA intensively identify events and improve recall and precision of starting point of event. Copyright © 2016 John Wiley & Sons, Ltd.
The potential of identification of a malignancy‐associated biomarker in breast cancer diagnosis and research: hTERT gene DNA methylation
Authors: Masood Shahla , El‐Gabry Ehab , Zhang Chuhua , Wang Zhiqianq 
Published: May 2016

BackgroundDNA hypermethylation has been documented to be prominent at a CpG island rich region about 600 bp upstream the transcription start site of the hTERT gene using qualitative methylation specific PCR on DNA isolated from tumor cell lines. In order to assess the potential significance of this biomarker in breast cancer research and diagnosis, we explored if such findings are reproducible on surgically resected fresh breast tumor cells.MethodsUsing quantitative pyrosequencing technology, we investigated and present methylation status of four CpG islands of this region in a cohort of 77 invasive breast carcinomas using normal breast tissue as controls.ResultsGlobally, a significant hypermethylation in tumor cells was observed in the four CpG islands as a sum, in comparison to methylation of the normal breast tissue. Individually, certain CpG islands displayed methylation greater than 50% in about 3/4 of the 77 breast cancers, but in none of the normal breast tissue. Our results highlight the value of DNA hypermethylation in the −600 bp region of the hTERT gene as a potential marker for breast cancer diagnosis.ConclusionsWe believe that integration of this novel, malignancy‐associated molecular testing with morphology is of significant value in the accurate interpretation of small tumor sample size obtained via fine needle aspiration biopsy, ductal lavage, and nipple fluid aspirates both in clinical practice and in breast cancer research. Diagn. Cytopathol. 2016;44:670–675. © 2016 Wiley Periodicals, Inc.
Genetic differentiation of the pine processionary moth at the southern edge of its range: contrasting patterns between mitochondrial and nuclear markers
Authors: El Mokhefi M'hamed , Kerdelhué Carole , Burban Christian , Battisti Andrea , Chakali Gahdab , Simonato Mauro 
Published: May 2016

AbstractThe pine processionary moth (Thaumetopoea pityocampa) is an important pest of coniferous forests at the southern edge of its range in Maghreb. Based on mitochondrial markers, a strong genetic differentiation was previously found in this species between western (pityocampaclade) and eastern Maghreb populations (ENAclade), with the contact zone between the clades located in Algeria. We focused on the moth range in Algeria, using both mitochondrial (a 648 bp fragment of thetRNA‐cox2) and nuclear (11 microsatellite loci) markers. A further analysis using a shorter mtDNAfragment and the same microsatellite loci was carried out on a transect in the contact zone between the mitochondrial clades. Mitochondrial diversity showed a strong geographical structure and a well‐defined contact zone between the two clades. In particular, in thepityocampaclade, two inner subclades were found whereasENAdid not show any further structure. Microsatellite analysis outlined a different pattern of differentiation, with two main groups not overlapping with the mitochondrial clades. The inconsistency between mitochondrial and nuclear markers is probably explained by sex‐biased dispersal and recent afforestation efforts that have bridged isolated populations.
Seasonal spatial dynamics of floodplain macrophyte and periphyton abundance in the Alligator Rivers region (Kakadu) of northern Australia
Authors: Ward D. P. , Pettit N. E. , Adame M. , Douglas M. M. , Setterfield S. A. , Bunn S. E. 
Published: May 2016

AbstractIsotope studies of freshwater aquatic habitats have shown that epiphytic algae in the form of periphyton provides much of the source material for the biomass of secondary aquatic producers. Consequently, methods that can quantify the seasonal abundance of periphyton are important spatial inputs for wetland management and conservation planning processes for tropical floodplains. In this study, estimation of the seasonal spatial variability in floodplain macrophyte and periphyton abundance was made for the floodplains of the Kakadu region in northern Australia. Statistical modelling, using remotely sensed information, was applied to predict the seasonal distributions of macrophyte structural types, which were then combined with the field measurements of periphyton biomass to produce seasonal distributions of floodplain periphyton biomass per unit area. The seasonal spatial distribution of periphyton was strongly influenced by the seasonal variation in macrophyte abundance. Vertical emergent macrophytes (mainly aquatic grasses), covering 70% of the floodplain in May, had the lowest periphyton abundance. Submerged macrophytes, covering 10–15% of the floodplains, had the greatest periphyton abundance. The submerged macrophytes occupied open water areas, mainly in the deeper backswamp areas on the edges of the floodplains, and these areas maintained high periphyton abundance into the dry season. This study provides explicit spatial representation of the seasonal dynamics of tropical floodplain macrophyte and periphyton abundance and presents an approach that can be applied to map ‘hotspots’ of floodplain periphyton abundance. Copyright © 2016 John Wiley & Sons, Ltd.
Differences in movements of northern pike inhabiting rivers with contrasting flow regimes
Authors: Harvey‐Lavoie Simonne , Cooke Steven J. , Guénard Guillaume , Boisclair Daniel 
Published: May 2016

AbstractLittle is known about the effect of short‐term flow changes on the movement of northern pike (Esox lucius L.). We conducted a comparative study in two rivers with different flow regimes (i.e. one regulated and one unregulated) to evaluate the extent to which adult northern pike movement is influenced by short‐term river flow conditions. Data on northern pike hourly movement were collected in northeastern Ontario on 40 individuals in the Mississagi River, a river subjected to extreme daily flow variations associated with hydro‐electric operations (i.e. hydropeaking), and the Aubinadong River, an unregulated river. Using manual tracking by radio‐telemetry, we found that northern pike moved at a higher rate in the river subjected to short‐term changes in river flow than in the unregulated river. Results also show that the relationship between movement of northern pike and flow can vary among rivers. In the Mississagi River, flow had a significant positive effect on northern pike activity, while the effect of flow in the Aubinadong River depended on water temperature. Moreover, fish in the Mississagi River utilized a restricted river section and travelled more laterally in comparison to fish inhabiting the Aubinadong River, where longer upstream‐downstream movements were more common. The present study contributes to our understanding of the effects of short‐term changes in flow on fish movement. This constitutes the first step towards assessing the effect of flow on fish habitat use, and eventually developing flow management strategies to mitigate impacts on fish. Copyright © 2016 John Wiley & Sons, Ltd.
Streptavidin‐polypyrrole Film as Platform for Biotinylated Redox Probe Immobilization for Electrochemical Immunosensor Application
Authors: Miodek Anna , Lê Huu Quynh Anh , Sauriat‐Dorizon Helene , Korri‐Youssoufi Hafsa 
Published: May 2016

AbstractA platform for construction of multi‐array electrochemical immunosensors was developed in which the measurement could be performed by various targets depending on the potential ranges of electrochemical detection. This was demonstrated by the immobilization of biotinylated redox molecules such as viologen and ferrocene, on modified polypyrrole‐streptavidin film. The polypyrrole film was modified by streptavidin layer, which serves for both the attachment of biotinylated redox marker and biotinylated antibody. Such biologically modified surface exhibits variation of electrochemical response of redox molecule at various potential ranges after antibody/antigen interaction. The measurement of redox signal of viologen and ferrocene was analyzed by differential pulse voltammetry (DPV) method and underlines a variation of redox properties upon the antigen interaction. Viologen immobilized on polypyrrole /streptavidin surface shows a redox signal at −1.2 V versus Ag/AgCl corresponding to the reduction of dicationic viologen to neutral viologen within 2 electrons process. Immobilized biotinylated ferrocene exhibits redox signal at 0.4 V versus Ag/AgCl. We demonstrate that when the biolayer bearing antibody is in contact with antigen, the redox signal of ferrocene or viologen was modified. The variation of current signal is directly related to the concentration of antigen in solution. A detection limit of pg.mL−1 was obtained demonstrating the sensitivity of such electrochemical immunosensor. The modified streptavidin polypyrrole surface bearing various biotinylated redox markers is a proof of concept for multi‐array electrochemical detection system of complex sample.
Sr–Nd–Pb isotopic geochemistry of phenocrysts in pumice from the central Okinawa Trough
Authors: Guo Kun , Zhai Shikui , Yu Zenghui , Cai Zongwei , Zhang Xia 
Published: May 2016

AbstractPumice is the most widely distributed magmatic rock in the Okinawa Trough. Numerous scholars have conducted extensive research on the mineralogy, petrochemistry and whole‐rock isotopic characteristics of pumice. However, even with extensive research, some information about pumice is still unknown, including the initial provenance of magma, influences from subducting plates and the possibility of crustal material (including sediments) mixing in during pumice formation. As pumice is loose and porous, seawater re‐modification and injection of sediments may occur during the condensation and rock‐forming process after magma erupts from the seafloor, or in the seawater immersion process after pumice formation. In order to get a better understanding of the isotopic characteristics of magmatism phase, phenocrysts were first separated from the pumice and divided into both light and heavy minerals to analyse their Sr–Nd–Pb isotopic composition. This information was combined with existing isotopic data of volcanic rocks from the Okinawa Trough and its adjacent areas to assess the magma source composition, influence from subduction components and mantle properties in the magmatic source. The research results indicated light minerals had an average 87Sr/86Sr ratio of 0.70454, while heavy minerals averaged 0.70546. The magma, formed pumice, was a product of the crystal fractionation evolution of basic magma, with the additional injection of crustal material. The magma source in the central trough is a mixture of depleted MORB mantle (DMM) and enriched mantle (EMI‐like and EMII‐like) end members, where the EMI‐like end member is the residual subcontinental lithosphere or lower crustal material and the EMII‐like end member is subducted oceanic sediments. The Pb isotopic composition indicated that the magma source was affected by subduction components (sediments) and that pumice magma was mixed with more sediment than basalt magma material in the same area. The mantle of the magma source in the Okinawa Trough showed signatures of the Indian Ocean‐type mantle. Copyright © 2016 John Wiley & Sons, Ltd.
Hemolysis Affects C‐Peptide Immunoassay
Authors: Wu Zhi‐Qi , Lu Ju , Xu Hua‐Guo 
Published: May 2016

BackgroundC‐peptide is used widely as a marker of insulin secretion, and it participates in the inflammatory response and contributes to the development of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). Previous studies have reported that C‐peptide measurement was unaffected by hemolysis. However, we found that hemolysis negatively affected C‐peptide assay in routine laboratory practice. We further established and validated an individualized hemolysis correction equation to correct and report accurate serum C‐peptide results for hemolyzed samples.MethodsWe studied the effects of hemolysis on C‐peptide assay by adding lysed self red blood cells (self‐RBCs) to serum. An individualized correction equation was derived. Further, we evaluated the performance of this individualized correction equation by artificially hemolyzed samples.ResultsC‐peptide concentration decreased with increasing degree and exposure time of hemolysis. The individualized hemolysis correction equation derived: C‐Pcorr = C‐Pmeas/(0.969−1.5Hbserum/plasma−5.394 ×10−5 Time), which can correct bias in C‐peptide measurement caused by hemolysis.ConclusionsHemolysis negatively affects C‐peptide measurement. We can correct and report accurate serum C‐peptide results for a wide range of degrees of sample hemolysis by individualized hemolysis correction equation for C‐peptide assay. This correction would improve diagnostic accuracy and reduce inappropriate therapeutic decisions.
Use of the retrograde limb of the internal mammary vein to avoid venous congestion in DIEP flap breast reconstruction: Further evidences of a reliable and time‐sparing procedure
Authors: La Padula Simone , Hersant Barbara , Noel Warren , Niddam Jeremy , Hermeziu Oana , Bouhassira Jonathan , Bosc Romain , Meningaud Jean Paul 
Published: May 2016

AimVenous congestion is a common cause of DIEP flap failure. When identified intraoperatively, an additional venous anastomosis can improve the venous outflow and prevent flap failure. The aim of this study was to assess if the retrograde limb of the internal mammary vein (IMV) could be considered a good recipient vessel to be used when persistent flap congestion is present, and a second venous anastomosis is required.Patients and methodsA retrospective study was conducted in 74 patients who had undergone DIEP flap breast reconstruction. Patients were classified into two groups: SVA (single venous anastomosis) and DVA (dual venous anastomosis). In the SVA group (n = 38), the IMV antegrade limb was used for venous drainage. A single DIEV (Deep Inferior Epigastric Vein) was anastomosed to the superior arm of the IMV. In the DVA group (n = 36), both the antegrade (superior) and retrograde (inferior) stumps of the IMV were used, connecting the larger DIEV to the antegrade IMV and the other DIEV or the SIEV (Superficial Inferior Epigastric Vein) to the IMV retrograde limb.ResultsNo venous congestion or flap loss was observed when two venous anastomoses were performed using both the IMV antegrade and retrograde limbs (P = 0.3271). In the DVA group, no major complication occurred (P = 0.0453). Operative explorations were significantly reduced in the DVA group (P = 0.0242).ConclusionThese findings suggest that when an additional venous outflow is required, the use of the IMV retrograde limb may help to avoid flap venous congestion. © 2016 Wiley Periodicals, Inc. Microsurgery 36:447–452, 2016.