bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functionalized nanostructures and targeted delivery systems with a focus on plant-derived natural agents for COVID-19 therapy: A review and outlook
Authors: AbouAitah Khaled , Kim Beom Soo , Lojkowski Witold 
Published: October 2024

Abstract
The COVID-19 pandemic strongly stimulated research on anti-SARS-CoV-2 virus treatments. The present study reviews a nanotechnology approach to this task, i.e., in other terms, a nanomedicine approach. Nanotechnology aims to create nanostructures or nanoparticles, also called nanoformulations, for targeted delivery of drugs, as well as improved drug release control. This approach is particularly promising to enhance the antiviral effect of natural pro-drugs. Here, we review several nanoformulations developed for the targeted delivery of medications against SARS-CoV-2. We draw special attention to repurposing strategies for known antiviral and natural therapies. Also, functionalized nanoparticles with specific targeting moieties and functional groups were discussed. The summary could motivate researchers to pursue more studies in this exciting area by seeking nanotechnology-based, cutting-edge, tailored delivery strategies for the SARS-CoV-2 virus.
Utilizing Ziziphus spina-christi for eco-friendly synthesis of silver nanoparticles: Antimicrobial activity and promising application in wound healing
Authors: Abdellatif Ahmed A. H. , Mostafa Mahmoud A. H. , Khojah Hani M. J. , Al Haidari Rwaida A. , Tawfeek Hesham M. , Soliman Ghareb M. , Al Thagfan Sultan S. , Faris Tarek M. , Tolba Nahla Sameh 
Published: October 2024

Abstract
Wound healing is a critical process essential for the body’s recovery from injuries, often complicated by bacterial infections. Silver nanoparticles (AgNPs) have gained attention due to their antibacterial and tissue-regenerative properties. However, conventional chemical synthesis methods for AgNPs pose environmental risks. This study utilizes Ziziphus spina-christi (ZSC) extract for the eco-friendly synthesis of AgNPs, evaluating their antibacterial and wound-healing capabilities. The AgNPs-ZSC showed an absorption maximum at λ
max of 460 nm, a particle size of 111.2 ± 1.09 nm, a polydispersity index of 0.38 ± 0.006, and a zeta potential of −27.0 ± 0.231 mV. The synthesized AgNPs-ZSC were spherical, non-aggregated, and exhibited potent antibacterial activity superior to chloramphenicol. Furthermore, the AgNPs-ZSC cream significantly promoted wound closure, epithelial tissue proliferation, and granulation tissue formation in rats, showing no signs of toxicity or adverse reactions. In conclusion, AgNPs-ZSC cream demonstrates excellent antibacterial and wound-healing properties, presenting a sustainable alternative to conventional chemical methods for AgNP synthesis.
Lupus erythematosus panniculitis presenting with initial periorbital swelling and positive antiphospholipid antibodies: A rare association
Authors: Oak Jyotsna , Rais Sama , Sawant Shankar 
Published: October 2024

Lupus erythematosus panniculitis (LEP), an unusual form of chronic cutaneous lupus erythematosus, is characterized by chronic inflammation and fibrosis of subcutaneous tissue. Clinically, it presents as subcutaneous nodules on common locations such as forehead, cheeks, proximal limbs and buttocks. Ulceration of the nodules may occur in certain cases. Very few case studies have reported the occurrence of early solitary periorbital involvement, highlighting the need for a high index of suspicion in such cases. We report here a case having generalized extensive LEP with initial manifestation of a solitary periorbital swelling, autoimmune hemolytic anemia, and associated antiphospholipid antibodies positivity.
A complex remodeling of cellular homeostasis distinguishes RSV/SARS-CoV-2 co-infected A549-hACE2 expressing cell lines
Authors: Vanetti Claudia , Saulle Irma , Artusa Valentina , Moscheni Claudia , Cappelletti Gioia , Zecchini Silvia , Strizzi Sergio , Garziano Micaela , Fenizia Claudio , Tosoni Antonella , Broggiato Martina , Ogno Pasquale , Nebuloni Manuela , Clerici Mario , Trabattoni Daria , Limanaqi Fiona , Biasin Mara 
Published: October 2024

Abstract
Concurrent infections with two or more pathogens with analogous tropism, such as RSV and SARS-CoV-2, may antagonize or facilitate each other, modulating disease outcome. Clinically, discrepancies in the severity of symptoms have been reported in children with RSV/SARS-CoV-2 co-infection. Herein, we propose an in vitro co-infection model to assess how RSV/SARS-CoV-2 co-infection alters cellular homeostasis. To this end, A549-hACE2 expressing cells were either infected with RSV or SARS-CoV-2 alone or co-infected with both viruses. Viral replication was assessed at 72 hours post infection by droplet digital PCR, immunofluorescence, and transmission electron microscopy. Anti-viral/receptor/autophagy gene expression was evaluated by RT-qPCR and confirmed by secretome analyses and intracellular protein production. RSV/SARS-CoV-2 co-infection in A549-hACE2 cells was characterized by: 1) an increase in the replication rate of RSV compared to single infection; 2) an increase in one of the RSV host receptors, ICAM1; 3) an upregulation in the expression/secretion of pro-inflammatory genes; 4) a rise in the number and length of cellular conduits; and 5) augmented autophagosomes formation and/or alteration of the autophagy pathway. These findings suggest that RSV/SARS-CoV-2 co-infection model displays a unique and specific viral and molecular fingerprint and shed light on the viral dynamics during viral infection pathogenesis. This in vitro co-infection model may represent a potential attractive cost-effective approach to mimic both viral dynamics and host cellular responses, providing in future readily measurable targets predictive of co-infection progression.
Economic policy and public health: Insights from the history of the Canadian Journal of Public Health
Authors: McLaren Lindsay , Mykhalovskiy Eric 
Published: October 2024

AbstractThe nearly 115-year history of the Canadian Journal of Public Health (CJPH) provides an important opportunity to reflect on and learn from our past. In response to an invitation to members of the CJPH Editorial Board to curate historical articles around a theme, we undertook a historical examination of our field’s engagement, as gleaned through the pages of CJPH, with economic policy. This was inspired by the now well-established connections among political economic policy, population well-being, and health equity. Our analysis of six historical volumes (1917, 1933, 1941, 1961, 1995, and 2013) led to three key findings. First, we found only a slim historical foundation for public health engagement with the economy overall. Second, we observed a strong and seemingly subconscious allegiance to dominant economic paradigms, despite their incompatibility with root causes of health inequities. Third, even though socio-economic inequalities in health are a long-standing preoccupation of CJPH authors, those inequalities are consistently and curiously divorced from their roots in political economic systems. Our findings provide a historical foundation for thinking about how our public health community could be encouraged to engage constructively towards an economic system that supports, rather than obstructs, population well-being and health equity.
Adubação Nitrogenada em Híbridos de Milho em Semeadura Tardia na Amazônia Paraense
Authors: Magalhães de Souza Ronan , Vieira dos Santos Jarlyr , Sérgio Bastos de Matos Gilson , Bicioni Pacheco Adriano , Sobral Sampaio Leila , Gomes Viana Rafael , Marie Ohashi Alessandra 
Published: October 2024

Em parte do território brasileiro os fatores climáticos podem limitar o plantio de milho tardio, porém, no Pará, esta estratégia apresenta condições de contribuir para a redução da pressão sobre a floresta, principalmente quando a adubação nitrogenada é empregada, possibilitando rendimentos acima da média nacional. Neste sentido, com o objetivo de avaliar a influência de doses de nitrogênio aplicadas em híbridos de milho semeados de forma tardia, este ensaio foi conduzido em um esquema fatorial 2 x 4 com dois milhos (K9606 e 30F35) e quatro doses de nitrogênio (0, 50, 100 e 200 kg ha-1). O número de folhas verdes e total, apresentou diferença para os milhos, sendo maiores no híbrido 30F35. A altura de plantas, diâmetro do colmo e comprimento de folhas responderam com um ajuste quadrático ao nitrogênio com doses próximas de 150 kg ha-1. A produção de grãos, o comprimento e o diâmetro da espiga ajustaram-se de forma linear crescente à fertilização com ureia, sem diferença entre os híbridos, demonstrando potencial de resposta para doses superiores a 200 kg ha-1 de nitrogênio. A adubação nitrogenada diminuiu a eficiência agronômica e a produtividade parcial do fator N.
Palavras-chave: Floresta. Grãos. Silagem. Ureia.

Abstract
In part of the Brazilian territory, climatic factors can limit the planting of late corn, however, in Pará, this strategy is able to contribute to reducing pressure on the forest, especially when nitrogen fertilization is used, enabling yields above the national average. In this sense, with the objective of evaluating the influence of nitrogen doses applied to corn hybrids sown late, this trial was conducted in a 2 x 4 factorial scheme with two corns (K9606 and 30F35) and four nitrogen doses (0, 50, 100 and 200 kg ha-1). The number of green and total leaves showed a difference for corn, being higher in the 30F35 hybrid. Plant height, stem diameter and leaf length responded with a quadratic adjustment to nitrogen with doses close to 150 kg ha-1. Grain production, ear length and diameter adjusted in a linearly increasing manner to urea fertilization, with no difference between hybrids, demonstrating potential response to doses greater than 200 kg ha-1 of nitrogen. Nitrogen fertilization decreased agronomic efficiency and partial productivity of the N factor.
Keywords: Forest. Grains. Silage. Urea.
Fear of Missing Out (FOMO): Exploring Its Relationship with Self-Control and Self-Regulation in College Students
Authors: Amelisastri Windy , Yandri Hengki , Kholidin Farid Imam 
Published: October 2024

This study investigates the potential influence of self-control and self-regulation on Fear of Missing Out (FoMO) among students. FoMO is characterized by an apprehension of being excluded from significant experiences or opportunities. Individuals with low self-control may struggle to prioritize positive behaviors, potentially leading to heightened FoMO. Similarly, a lack of self-regulation, the ability to manage thoughts and guide actions towards goals, might exacerbate FoMO. The current research employs a quantitative, descriptive correlational design. The study population comprised 2,245 students from the Faculty of Tarbiyah and Teacher Training at Institut Agama Islam Negeri Kerinci. A sample of 304 participants, representing 10 departments, was selected. Data collection utilized three validated scales: the Self-Control Scale, the Self-Regulation Questionnaire, and the Fear of Missing Out Scale. The hypothesis proposing a significant negative association between self-control/self-regulation and FoMO was supported (p < 0.05). This suggests that both self-control and self-regulation have a combined effect on FoMO. In simpler terms, individuals with greater self-control and self-regulation may experience lower levels of FoMO. Future research could explore specific factors contributing to FoMO development. Additionally, expanding the sample size might enhance the generalizability of findings.
Operative First Web Contracture Management: Current Strategies
Authors: Wallace Doyle R. , Floyd Waldo E. 
Published: October 2024

Abstract

» First web contractures can be due to nonthermal trauma, burns, congenital differences, and Dupuytren contracture.» Mild cases are managed with contracture release and full-thickness skin graft or when surrounding skin is pliable, Z-plasty.» Release of severe contractures creates a tetrahedral void that may require local or distant flap coverage. Reconstructive options include dorsal transposition flaps, regional rotation flaps, free tissue transfer, first metacarpal distraction osteogenesis with web deepening, or pollicization.
Musculoskeletal Learning and Knowledge Retention Among Postgraduate Physicians: Evaluating the Long-Term Impact of a New Preclerkship Curriculum at a Nationally Accredited Medical Program
Authors: Orchard Taylor , Hryniuk Alexa , Peeler Jason 
Published: October 2024

Introduction:
Musculoskeletal (MSK) injuries and disorders are exceptionally prevalent in the clinical setting. Despite this, physician training in MSK medicine has been historically inadequate contributing to a lack of MSK knowledge, confidence, and clinical skills among postgraduate physicians. The goal of this investigation was to examine the long-term impact of a new preclerkship MSK curriculum implemented by a nationally accredited medical program on postgraduate physician's learning and knowledge retention in the area of MSK medicine.

Methods:
Five hundred sixty-eight postgraduate physicians (years 1–6) who had previously completed the new curriculum over a 6-year period were recruited to complete a standardized and validated MSK examination that consisted of 30 multiple-choice questions on core or must-know topics in MSK medicine that could be directly mapped to learning objectives within the new preclerkship MSK curriculum.

Results:
Ninety postgraduate physicians completed the examination, obtaining an average score of 75.0% (±10.2; range 57.0-100.0). Physicians who completed MSK-related electives during clerkship training or specialized in fields related to MSK medicine (i.e., orthopaedics, PM&R, sports medicine, and rheumatology) performed significantly better on the MSK examination (p ≤ 0.01).

Conclusion:
Data indicated that the program's new preclerkship curriculum supports high levels of MSK learning and knowledge retention among postgraduate physicians. These findings are expected to assist with the establishment of minimum curriculum standards and can be used to guide MSK curricular reform at other medical programs.
Utilizing Instagram Accounts for Business as a Tourism Marketing Communication Strategy in the New Normal Period
Authors: Aspriyaningsih Yenny , Aesthetika Nur Maghfirah 
Published: October 2024

This study examines how to use Instagram as a tourism strategy marketing communication in new normal period at the Hawai Waterpark Malang. In this study, used an analytical in the form of a tourism marketing communication strategy theory (elements marketing mix) utilizing the features that exist on Instagram for business. The purpose of this study was to determine whether the use of Instagram accounts can help tourism marketing communication. This research uses descriptive qualitative methods. The datas are collected by documentation, observation and interviews with the managers of Hawai Waterpark Malang. The results of the study show that the use of Instagram accounts as a tourism marketing communication strategy during the New Normal is very helpful for marketing communication activities. The features offered by Instagram business make the marketing communication process more efficient. Instagram carries of information between Hawai Waterpark Malang and consumers who will visit Hawai Waterpark Malang.
Reviving Ancient Splendor: Graphic Restoration of the Mosque of Odina in Uzbekistan
Authors: Jurayeva Elvira , Dilshod Luqmonov , Olimova Odina 
Published: October 2024

This study delves into the graphic restoration of the historic mosque of Odina in Karshi, Uzbekistan, as part of broader efforts to preserve and repair architectural treasures in post-independence Uzbekistan. Utilizing archival data, historical sources, and scientific research, the study aims to recreate the original appearance and architectural elements of this significant monument. Through meticulous analysis and reconstruction, the project yields detailed insights into the early aesthetics; and construction techniques of the mosque, contributing valuable knowledge to the global discourse on heritage conservation and historical architecture.
Higlights:

Graphic restoration techniques employed archival data, historical sources, and scientific research for authenticity.
The study focuses on recreating the original appearance and architectural elements of the historic mosque of Odina in Karshi, Uzbekistan.
Insights gained contribute to global discussions on heritage conservation and historical architecture.

Keywords: Mosque Restoration, Historical Preservation, Architectural Heritage
Optimizing Village Wealth Through the Transition to BUMDes in Indonesia
Authors: Tamaputra Moch Rifqi , Phahlevy Rifqi Ridlo 
Published: October 2024

This research examines the regulation of transitioning village assets to Village-Owned Enterprises (BUMDes) based on Village Law, highlighting shifts in dispute resolution methods. Using a normative method with statutory and historical approaches, the study identifies challenges in optimizing village head authority and effective supervision by regional heads. Key findings show the transition process involves initiation and agreements between BUMDes and village government, with tailored dispute resolution methods including mediation and litigation. Effective regulations and collaboration between officials and asset managers can enhance BUMDes' self-sufficiency, benefiting local economies and village welfare while ensuring transparency and community participation.Highlight:

Transition Process: Village assets to BUMDes via initiation and agreements.
Dispute Resolution: Methods include mediation, village discussions, and litigation.
Regulatory Challenges: Enhance village head authority and regional supervision.

Keywoard: Village assets, BUMDes, Village Law, Dispute resolution, Normative method
Transformational Leadership Boosts Employee Performance in Indonesia
Authors: Putri Reni Eka , Sumartik  
Published: October 2024

This study examines the impact of Transformational Leadership Style, Organizational Culture, and Work Climate on Employee Performance at the Community and Village Empowerment Offices in Sidoarjo District. Using a quantitative approach, data were collected from 100 employees through surveys and analyzed with multiple linear regression using SPSS version 25. Results show that all three factors positively influence employee performance, with Organizational Culture being the most significant. This research underscores the importance of enhancing organizational culture to boost employee performance, providing valuable insights for policymakers and practitioners in village empowerment.
Highlight:

Transformational Leadership: Positively impacts employee performance.
Organizational Culture: Most significant factor affecting performance.
Quantitative Analysis: Utilized surveys and regression analysis.

Keywoard: Transformational Leadership, Organizational Culture, Work Climate, Employee Performance, Village Empowerment
Empowering Rural Economies through BUMDes Initiatives in Indonesia
Authors: Munfaati Indah , Choiriyah Ilmi Usrotin 
Published: October 2024

This qualitative study investigates the economic empowerment efforts through the "BUMDes Makmur Sejahtera" program in Pagerwojo Village, Buduran District, Indonesia, aligning with governmental regulations on village-owned enterprises. Using purposive sampling, data was collected via observation, interviews, and documentation. The analysis, guided by Miles & Huberman's model, highlights successful planning and policy adherence, community engagement through social and political actions, and the impact of awareness and education in enhancing local economic resilience. Key findings emphasize the need for improved marketing strategies and service quality to sustain and expand the program's benefits, positioning BUMDes as a pivotal tool for inclusive economic growth in rural communities, contingent on ongoing management and development efforts.
Highlights:

Strategic planning vital for BUMDes success in rural economic empowerment.
Community engagement fosters effective governance and program sustainability.
Education and awareness crucial for enhancing local economic resilience and growth.

Keywords: BUMDes, economic empowerment, rural development, community engagement, qualitative research
Indonesia's Digital Push to Combat Literacy Crisis
Authors: Yonanda Deny Firmansyah , Choiriyah Ilmi Usrotin 
Published: October 2024

This study investigates the government's role in improving literacy rates in Sidoarjo, Indonesia, where reading interest is the lowest in ASEAN. Using a descriptive qualitative method, interviews with library officials revealed that innovative programs and digital media are key to enhancing public engagement. The research highlights the Sidoarjo government's implementation of smart city applications and digital resources to support education and public services. Results indicate that practical information and effective use of digital tools are essential for increasing literacy. This study underscores the importance of government initiatives in addressing literacy challenges and improving educational outcomes.
Highlights:

Government Initiatives: Smart city applications and digital tools boost literacy in Sidoarjo.
Low Literacy Rates: Indonesia's lowest reading interest in ASEAN needs urgent intervention.
Innovative Programs: Digital media and practical information enhance public engagement and literacy.

Keywords: Literacy, Government Role, Digital Media, Education, Sidoarjo
Digitizing Traditional Health in Indonesia Unlocks Community Potential
Authors: Martati Badruli , Firmannandya Ade , Cahya Kartika Pheni , Mukarrohmah Nur 
Published: October 2024

This study addresses the digital gap in administration and marketing within traditional health practices, focusing on the asman as-shihah group in Jumputrejo Village. Traditional health practices like Family Medicine Gardens (TOGA) and acupressure are vital for community health but often lack digital integration.Employing a participatory approach with stages of preparation, implementation, and evaluation, we explored the adaptation of digital tools for administration and ICT for marketing. The program showed that digital skills significantly enhance the efficiency and reach of traditional health practices, suggesting that digital integration can promote sustainable community health initiatives. Future research should further investigate the long-term impacts of digitalization across other regions.
Highlights:

Digital Tools Boost Efficiency: Enhances administration and outreach.
Community-Based Approach: Tailored, practical solutions.
Sustainability: Digital adoption promotes long-term community health.

Keywords: Digitalization, Traditional Health Practices, Community Health, ICT, Sustainable Development