bluuebunny/crossref_metadata_2025_split huggingface dataset:
Initiation of ERAD by the bifunctional complex of Mnl1 mannosidase and protein disulfide isomerase
Authors: Zhao Dan , Wu Xudong , Rapoport Tom A. 
Published: October 2024

AbstractMisfolded glycoproteins in the endoplasmic reticulum (ER) lumen are translocated into the cytosol and degraded by the proteasome, a conserved process called ER-associated protein degradation (ERAD). InS. cerevisiae, the glycan of these proteins is trimmed by the luminal mannosidase Mnl1 (Htm1) to generate a signal that triggers degradation. Curiously, Mnl1 is permanently associated with protein disulfide isomerase (Pdi1). Here, we have used cryo- electron microscopy, biochemical, andin vivoexperiments to clarify how this complex initiates ERAD. The Mnl1-Pdi1 complex first de-mannosylates misfolded, globular proteins that are recognized through a C-terminal domain (CTD) of Mnl1; Pdi1 causes the CTD to ignore completely unfolded polypeptides. The disulfides of these globular proteins are then reduced by the Pdi1 component of the complex, generating unfolded polypeptides that can be translocated across the membrane. Mnl1 blocks the canonical oxidative function of Pdi1, but allows it to function as the elusive disulfide reductase in ERAD.
A limbal stem cell deficiency murine model with residual limbal stem cells
Authors: Someya Hideaki , Shirahama Shintaro , Karg Margarete M. , Gregory-Ksander Meredith S. , Dana Reza , Ksander Bruce R. 
Published: October 2024

AbstractBilateral limbal stem cell deficiency (LSCD) is a significant cause of corneal blindness and is more difficult to treat, as compared with unilateral LSCD because no source of autologous limbal stem cells (LSCs) remains in these patients. Thus, bilateral patients could be candidates for treatment with allogeneic LSC transplants that require long-term systemic immunosuppression therapy. Thus, if possible, for the correct candidates, using autologous LSCs could be a preferred treatment. Recentin vivolaser confocal microscopic examination of the ocular surfacein situ, combined with impression cytology, has indicated that some patients diagnosed with a complete bilateral LSCD possess residual LSCs. However, it remains unknown whether these residual LSCs still have stem cell potential due to the lack of animal models that mimic this pathology. The goal of the current study is to make a complete LSCD model that possesses evidence of residual LSCs. We induced complete LSCD in mice using two methods: (1) removed the corneal epithelium and the epithelial basement membrane using a rotating burr, and (2) removed the corneal epithelium using 20% ethanol but retained an intact epithelial basement membrane. A complete LSCD was defined by a lack of CK12-positive corneal epithelial cells and the presence of infiltrating CK19-positive conjunctival epithelial cells. Corneas were examined for wound closure, corneal opacity, LSC exhaustion, and inflammation. We observed that complete LSCD mice without an intact epithelial basement membrane resulted in few residual LSCs. By contrast, complete LSCD mice that retained the epithelial basement membrane were accompanied by a reduced inflammatory response plus a significant number of residual LSCs. This model will allow future studies to determine the function of residual LSCs in complete LSCD.
A ZO-2 scaffolding mechanism regulates the Hippo signalling pathway
Authors: Liu Olivia Xuan , Lin Lester Bocheng , Bunk Soumya , Chew Tiweng , Wu Selwin K. , Motegi Fumio , Low Boon Chuan 
Published: October 2024

AbstractInhibition of proliferation upon contact is a critical cell density control mechanism governed by the Hippo signalling pathway. The biochemical signalling underlying cell density-dependent cues regulating Hippo signalling and its downstream effectors, YAP, remains poorly understood. Here, we reveal that the tight junction protein ZO-2 is required for the contact-mediated inhibition of proliferation. We additionally determined that the well-established molecular players of contact inhibition of proliferation, namely Hippo kinase LATS1 and YAP, are regulated by ZO-2, and that the scaffolding function of ZO-2 promotes the interaction with and phosphorylation of YAP by LATS1. Mechanistically, YAP is phosphorylated when ZO-2 brings LATS1 and YAP together via its SH3 and PDZ domains, respectively, subsequently leading to the cytoplasmic retention and inactivation of YAP. In conclusion, we demonstrate that ZO-2 maintains Hippo signalling pathway activation by promoting the stability of LATS1 to inactivate YAP.
Characterizing the diffuse continuum excitations in the classical spin liquid
h−YMnO3
Authors: Lass Jakob , Lenander Emma Y. , Krighaar Kristine M. L. , Tošić Tara N. , Prabhakaran Dharmalingam , Deen Pascale P. , Holm-Janas Sofie , Lefmann Kim 
Published: October 2024

We extend previous inelastic neutron scattering results on the geometrically frustrated antiferromagnet hexagonal-YMnO3, which has been suggested to belong to the class of classical spin liquids. We expand the energy transfer range of the diffuse signal up to 6.9 meV within a wide temperature range around the ordering temperature, TN. The two distinct diffuse signals in the a−b plane, the signal localized at Γ′ and the scattering intensity connecting Γ′ points over the M′, are shown to be only weakly energy dependent. In addition, an external magnetic field of up to 10.5 T applied along c is shown to have no effect on the diffuse signal. In the orthogonal scattering plane, the signals are shown to be dependent on l only through the magnetic form factor, showing that the correlations are purely two-dimensional, and supporting the origin of this to be the frustrated Mn3+ triangles. This result is corroborated by atomistic spin dynamics simulations showing similar scattering vector and temperature behaviors. Lastly, data for the spin wave scattering in the (h,0,l) plane allow for a discussion of the magnetic ground state where better agreement is found between the data and an ordered structure of the Γ1 or Γ3 symmetry, albeit crystal electric field arguments dismiss the Γ1 as a possibility.

Published by the American Physical Society
2024
Influence of scalar field in massive particle motion in JNW spacetime
Authors: Turimov Bobur , Davlataliev Akbar , Abdujabbarov Ahmadjon , Ahmedov Bobomurat 
Published: October 2024

In this paper, we investigated the motion of massive particles in the presence of scalar and gravitational fields, particularly focusing on the Janis-Newman-Winicour (JNW) naked singularity solution. It is shown that the innermost stable circular orbit radius strongly depends on scalar coupling parameter. Additionally, we explored the radiation reaction effects on particle dynamics, incorporating a reaction term into the motion equations. Numerical simulations indicated minimal impact on particle trajectories from radiation reaction. We also examined the oscillatory motion of particles around compact objects in the JNW spacetime, focusing on radial and vertical oscillations. Our analysis indicated that the scalar field’s coupling parameter and the spacetime deformation parameter n significantly alter the fundamental frequencies of these oscillations. Furthermore, we studied quasiperiodic oscillations (QPOs) in x-ray binaries, using the relativistic precession model to analyze upper- and lower-frequency relationships. Our results indicated that increasing parameters (n and gs) shifts the frequency ratio of 3∶2 QPOs closer to the naked singularity, with n decreasing and gs increasing both frequencies. Finally, we analyzed QPO data from four selected x-ray binary systems using Markov chain Monte Carlo analysis to constrain JNW parameters. Our findings provided insights into the mass, coupling, and deformation parameter for each system, enhancing our understanding of compact object dynamics in strong gravitational fields.

Published by the American Physical Society
2024
Dynamics behaviours of N-kink solitons in conformable Fisher–Kolmogorov–Petrovskii–Piskunov equation
Authors: Ullah Ikram 
Published: October 2024

PurposeThis manuscript is related to compute $N$-kink soliton solutions for conformable Fisher–Kolmogorov equation (CFKE) by using the generalized extended direct algebraic method (EDAM). The considered problem has important applications in mathematical biology and reaction diffusion processes. Also, the mentioned problem has significant applications in population dynamics. The fractional order conformable derivative has many features as compared to the other fractional order differential operators. For instance, the chain, product and quotient procedures do not satisfy by other fractional differential operators, but conformable operators obey the mentioned rules. Hence, we compute the soliton solutions for the mentioned problem and present its various dynamical behaviours graphically.Design/methodology/approachThe generalized EDAM is used in this article to examine the calculation of N-kink soliton solutions for the CFKE. In mathematical biology and reaction-diffusion processes, the topic under consideration holds great significance, especially when considering population dynamics.FindingsThe results highlight the benefits of utilising conformable derivatives in mathematical modelling and further our understanding of fractional differential equations and their applications.Research limitations/implicationsThe work focuses primarily on N-kink soliton solutions, which may limit the examination of alternative types of solutions (e.g., multi-soliton or periodic solutions) that might give new insights into the dynamics of the CFKE.Practical implicationsThe generated N N-kink soliton solutions can enhance mathematical models in biological contexts, notably in modelling population dynamics, disease propagation and ecological interactions, leading to better forecasts and interventions.Social implicationsPublic health initiatives can benefit from the understanding of disease transmission and intervention efficacy that comes from modelling population dynamics and reaction-diffusion processes.Originality/valueThe use of the generalized EDAM to obtain solutions for N-kink soliton problems is an innovative method for solving the conformable Fisher–Kolmogorov equation, demonstrating the power of this mathematical tool.
A new lens into workplace equity: the equity of employment systems
Authors: Lai Patrick Ho Lam , Hogan Deborah , McNamara Tay , Pitt-Catsouphes Marcie , Christensen Kathleen , Bradley Samuel L. 
Published: October 2024

PurposeThe unprecedented exigencies of COVID-19 and the subsequent spotlight on systemic racial, social and economic disparities have brought workplace equity to the forefront of organizational dialogue. These discontinuities set the stage for discussions about possible limitations of traditional diversity, equity and inclusion (DEI) approaches that may have overlooked disparities in specific organizational systems. In response, we conducted an exploratory study to examine a new framework that focuses attention on the equity of employment systems that contextualize employees’ experiences of equity at the workplace.Design/methodology/approachThis paper introduces a framework that focuses on the equity of ten key employment systems (job structures, compensation and benefits, recruitment and hiring, orientation and onboarding, supervision and mentoring, training and career development, employee performance assessment and feedback, employee resources and supports, promotion and separation). Combining the indices that measured the equity of these ten employment systems, we created an Overall Equity of Employment Systems Index and examined antecedent variables and outcomes related to the index. Data were gathered from HR leaders of 1,062 workplaces in the US.FindingsUtilizing multivariate analyses, this research found that lower scores on the Organizational Pressures Index were consistently linked to higher levels of equity across all of the employment systems. Furthermore, higher percentages of women and employees of color were positively associated with increased equity in most of the employment systems and in the Overall Equity of Employment System Index. There was a significant positive relationship between the Overall Equity of Employment Systems Index and organizational resilience, while a negative relationship was observed with employee stress.Practical implicationsThis study extends the existing DEI literature by offering a new framework that employers can use to: (1) assess the equity of specific employment systems and (2) strengthen the equity components of the employment systems.Originality/valueThe framework used for this exploratory study offers an alternative approach to the study of systemic equity in the workplace.
Coordination mechanisms applied to logistical systems for local disaster preparedness: a Latin American case
Authors: López-Vargas Juan Camilo , Meisel José D. , Cárdenas-Aguirre Diana María , Medina Pablo 
Published: October 2024

Purpose
The study aims to present an agent-based simulation model (ABM) for exploring interorganizational coordination scenarios in local disaster preparedness. This approach includes local actors and logistical processes as agents to compare various strategic coordination mechanisms.

Design/methodology/approach
The ABM model, developed in the Latin American context, specifically focuses on a case study of Colombia. Three coordination mechanisms (centralized, decentralized and cluster-type) have been evaluated using three performance indicators: effectiveness, efficiency and flexibility.

Findings
Simulation results show that the decentralized scenario outperforms in terms of efficiency and flexibility. On the contrary, the centralized and cluster-type scenarios demonstrate higher effectiveness, achieving a greater percentage of requirements coverage during the disaster preparedness stage. The ABM approach effectively evaluates strategical coordination mechanisms based on the analyzed performance indicators.

Research limitations/implications
This study has limitations due to the application of results to a single real case. In addition, the focus of the study is primarily on a specific type of disaster, specifically hydrometeorological events such as flash floods, torrential rains and landslides. Moreover, the scope of decision-making is restricted to key actors involved in local-level disaster management within a municipality.

Originality/value
The proposed ABM model has the potential as a decision-making tool for policies and local coordination schemes for future disasters. The simulation tool could also explore diverse geographical scenarios and disaster types, demonstrating its versatility and broader applicability for further insights and recommendations.
How broadband internet shapes household tourism decisions: a double/debiased machine learning-based difference-in-difference approach
Authors: Jia Haowen 
Published: October 2024

Purpose
This study aims to examine the influence of broadband internet on Chinese households’ tourism decisions and spending patterns. It reveals the transformative potential of digital connectivity in enhancing tourism activity.

Design/methodology/approach
Using a rigorous double/debiased machine learning-based difference-in-difference (DMLDiD) method and extensive panel data, this research quantitatively analyzes the impact of broadband on household tourism engagement and financial allocations. It incorporates comprehensive robustness checks, including placebo tests and algorithm variations, to ensure the validity of the findings.

Findings
Within households with broadband access, the results indicate a significant increase of 3.54% and 31.24% in tourism participation and tourism-related expenditures, respectively. This study attributes these outcomes to enhanced household incomes, facilitated online transactions and alleviated credit constraints, highlighting notable disparities in impact across urban versus rural settings and among distinct demographic categories. Additionally, the moderating effects of marital status and household size reveal that married households and a greater number of members tend to leverage broadband access more effectively for making tourism-related decisions and expenditures.

Originality/value
By pioneering the application of the DMLDiD approach to examine household financial behaviors toward tourism, this study contributes novel insights to the economic discourse on the role of digital infrastructure in tourism development. It offers empirical evidence and strategic implications for policymakers and industry professionals who seek to leverage digital connectivity to enhance tourism.
Navigating hospitality innovation (1995–2023): a bibliometric review and forward outlook
Authors: Peng Xuerong , Zhang Lian , Lee Seoki , Song Wenhao , Shou Keyan 
Published: October 2024

Purpose
This study aims to identify key contributors, research themes, research gaps, and future directions in hospitality innovation by conducting bibliometric and content analyses of peer-reviewed articles in this field.

Design/methodology/approach
A bibliometric analysis was conducted using VOSviewer software on 2,698 peer-reviewed English-language articles retrieved from the Web of Science database, published between 1995 and 2023. Key contributors were identified based on publication volume, citation, and co-citation analysis. Co-occurrence analysis of index keywords and content analysis of influential articles were used to identify research themes.

Findings
The study identified four distinct research themes in hospitality innovation: (1) digital technology adoption primarily among customers, (2) innovation management within hospitality firms, focusing on knowledge management and eco-innovation, (3) service innovation primarily among employees, and (4) business model innovation involving multiple stakeholders. Additionally, the study determined key contributors, highlighted research gaps, and provided suggestions for future research directions.

Originality/value
This study contributes to the existing literature by providing a systematic and in-depth review of hospitality innovation research. It identifies key contributors, research themes, and potential gaps for future research, offering valuable insights for both industry practitioners and scholars.
Islamic locus of control concept and its implications on individual behavior in organizations
Authors: Zakiy Muhammad , Santoso Claudius Budi , Rosari Reni , Tjahjono Heru Kurnianto 
Published: October 2024

Purpose
This paper aims to introduce the concept of Islamic locus of control (ILoC) and explores its influence on individual behavior within organizational contexts. It aims to integrate Islamic values into the traditional understanding of LoC and investigate how ILoC affects motivation, responsibility and resilience among Muslim individuals in the workplace.

Design/methodology/approach
Using a conceptual approach, this paper draws from Islamic sources such as the Qur’an and Hadith, as well as literature on psychology, human resource management and Islamic theology. It synthesizes relevant theories and concepts to develop a comprehensive understanding of ILoC and its significance in organizational settings.

Findings
ILoC encompasses key dimensions including ikhtiyar (effort), tawakkul (reliance on Allah) and qadr (Divine Decree), which shape individuals’ perceptions of control and action within organizations. Individuals with a high ILoC are expected to exhibit greater motivation, responsibility and resilience, while also maintaining acceptance of Allah’s decree.

Research limitations/implications
Future research should focus on developing valid measurement instruments for assessing ILoC and conducting empirical studies to test its impact on organizational outcomes.

Practical implications
Understanding and fostering a supportive environment for individuals with a high ILoC can enhance motivation, responsibility and overall productivity within Islamic organizations.

Social implications
Promoting an environment that respects and integrates religious beliefs can contribute to social cohesion and harmony within diverse organizational settings.

Originality/value
This paper contributes to the existing literature by introducing the novel concept of ILoC and offering insights into its implications for organizational behavior within Islamic contexts. It bridges the gap between psychology, human resource management and Islamic theology, providing a unique perspective on how religious beliefs influence individual behavior in the workplace.
When library cares: mining insights from LibQUAL+ to determine university students’ priorities
Authors: Zulfiqar Ayisha , Khalid Ayesha 
Published: October 2024

PurposeThis study aims to evaluate students' satisfaction with university library services in southern Punjab, Pakistan, emphasizing their perspective on service quality (SQ).Design/methodology/approachA LibQUAL+® survey with 22 core items was conducted within university settings using convenience sampling. In total, 345 usable responses were returned through Google Forms. Data analysis involved descriptive statistics, ordinal logistic regression test, Pearson and Deviance statistics and chi-square test to assess the satisfaction status of library users.FindingsThe study found that libraries generally meet SQ standards. However, there were minor gaps in information control (IC) and library as place (LP).Practical implicationsThe study provides library administrators with actionable insights to enhance services, encouraging stakeholders to adopt optimal library practices for heightened efficiency and user satisfaction.Social implicationsIt highlights the crucial role of libraries in shaping future societal progress by emphasizing the need for elevated user services. Librarians can use this knowledge to modify their planning and take impactful initiatives that align with the evolving needs of their users.Originality/valueWhile many studies have utilized LibQUAL, this research is unique for its focus on addressing university library services in underdeveloped regions facing economic challenges. It attempts to fill the information gap by offering a transferable approach for strategic priorities in similar settings.
Economics and financial sustainability in microfinancing: do investment flows toward developing countries, rural areas, microenterprises and female borrowers foster institutionalization?
Authors: Singh Kuldeep 
Published: October 2024

Purpose
The long-term sustainability of microfinancing institutions (MFIs) is essential for poverty reduction. This study aims to empirically evaluate whether contemporary microfinance economics supports the institutionalization of MFIs, which are crucial for the socioeconomic development of marginalized communities.

Design/methodology/approach
This research examines the flow of funds from wealthy economic areas (high-income countries, richer urban areas and capital-rich corporations) to poorer regions (low-income countries, poorer rural areas, female borrowers and financially constrained microenterprises) as a proxy for microfinance economics. Financial sustainability and institutionalization are assessed through return on assets and operational self-sufficiency. The study also considers credit risk as a key independent variable. Using panel data analysis of 333 MFIs from the USA and India, covering 2008–2018, sourced from the Microfinance Information Exchange data set on the World Bank website, this paper analyzes these dynamics.

Findings
Results show that credit risks negatively affect the financial sustainability of MFIs in both developed and developing countries. Contrary to expectations, the development status of a nation positively moderates the impact of credit risks on financial sustainability. In developing countries, intra-nation investments do not yield additional returns for MFIs or interact with credit risks. However, the economics of microfinance support the institutionalization of MFIs in these regions.

Originality/value
This study provides valuable empirical evidence on the relationship between microfinance economics and institutionalization, addressing a critical need in the microfinancing sector.