bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebellar Roles in Self-Timing for Sub- and Supra-Second Intervals
Authors: Ohmae Shogo , Kunimatsu Jun , Tanaka Masaki 
Published: February 2017

Previous studies suggest that the cerebellum and basal ganglia are involved in sub-second and supra-second timing, respectively. To test this hypothesis at the cellular level, we examined the activity of single neurons in the cerebellar dentate nucleus in monkeys performing the oculomotor version of the self-timing task. Animals were trained to report the passage of time of 400, 600, 1200, or 2400 ms following a visual cue by making self-initiated memory-guided saccades. We found a sizeable preparatory neuronal activity before self-timed saccades across delay intervals, while the time course of activity correlated with the trial-by-trial variation of saccade latency in different ways depending on the length of the delay intervals. For the shorter delay intervals, the ramping up of neuronal firing rate started just after the visual cue and the rate of rise of neuronal activity correlated with saccade timing. In contrast, for the longest delay (2400 ms), the preparatory activity started late during the delay period, and its onset time correlated with self-timed saccade latency. Because electrical microstimulation applied to the recording sites during saccade preparation advanced self-timed but not reactive saccades, regardless of their directions, the signals in the cerebellum may have a causal role in self-timing. We suggest that the cerebellum may regulate timing in both sub-second and supra-second ranges, although its relative contribution might be greater for sub-second than for supra-second time intervals.SIGNIFICANCE STATEMENTHow we decide the timing of self-initiated movement is a fundamental question. According to the prevailing hypothesis, the cerebellum plays a role in monitoring sub-second timing, whereas the basal ganglia are important for supra-second timing. To verify this, we explored neuronal signals in the monkey cerebellum while animals reported the passage of time in the range 400–2400 ms by making eye movements. Contrary to our expectations, we found that neurons in the cerebellar dentate nucleus exhibited a similar preparatory activity for both sub-second and supra-second intervals, and that electrical simulation advanced self-timed saccades in both conditions. We suggest that the cerebellum plays a causal role in the fine adjustment of self-timing in a larger time range than previously thought.
Spatial Tuning Shifts Increase the Discriminability and Fidelity of Population Codes in Visual Cortex
Authors: Vo Vy A. , Sprague Thomas C. , Serences John T. 
Published: February 2017

Selective visual attention enables organisms to enhance the representation of behaviorally relevant stimuli by altering the encoding properties of single receptive fields (RFs). Yet we know little about how the attentional modulations of single RFs contribute to the encoding of an entire visual scene. Addressing this issue requires (1) measuring a group of RFs that tile a continuous portion of visual space, (2) constructing a population-level measurement of spatial representations based on these RFs, and (3) linking how different types of RF attentional modulations change the population-level representation. To accomplish these aims, we used fMRI to characterize the responses of thousands of voxels in retinotopically organized human cortex. First, we found that the response modulations of voxel RFs (vRFs) depend on the spatial relationship between the RF center and the visual location of the attended target. Second, we used two analyses to assess the spatial encoding quality of a population of voxels. We found that attention increased fine spatial discriminability and representational fidelity near the attended target. Third, we linked these findings by manipulating the observed vRF attentional modulations and recomputing our measures of the fidelity of population codes. Surprisingly, we discovered that attentional enhancements of population-level representations largely depend on position shifts of vRFs, rather than changes in size or gain. Our data suggest that position shifts of single RFs are a principal mechanism by which attention enhances population-level representations in visual cortex.SIGNIFICANCE STATEMENTAlthough changes in the gain and size of RFs have dominated our view of how attention modulates visual information codes, such hypotheses have largely relied on the extrapolation of single-cell responses to population responses. Here we use fMRI to relate changes in single voxel receptive fields (vRFs) to changes in population-level representations. We find that vRF position shifts contribute more to population-level enhancements of visual information than changes in vRF size or gain. This finding suggests that position shifts are a principal mechanism by which spatial attention enhances population codes for relevant visual information. This poses challenges for labeled line theories of information processing, suggesting that downstream regions likely rely on distributed inputs rather than single neuron-to-neuron mappings.
Cep78 controls centrosome homeostasis by inhibiting EDD‐DYRK2‐DDB1VprBP
Authors: Hossain Delowar , Javadi Esfehani Yalda , Das Arindam , Tsang William Y 
Published: February 2017

AbstractThe centrosome plays a critical role in various cellular processes including cell division and cilia formation, and deregulation of centrosome homeostasis is a hallmark feature of many human diseases. Here, we show that centrosomal protein of 78 kDa (Cep78) localizes to mature centrioles and directly interacts with viral protein R binding protein (VprBP). Although VprBP is a component of two distinct E3 ubiquitin ligases, EDD‐DYRK2‐DDB1VprBP and CRL4VprBP, Cep78 binds specifically to EDD‐DYRK2‐DDB1VprBP and inhibits its activity. A pool of EDD‐DYRK2‐DDB1VprBP is active at the centrosome and mediates ubiquitination of CP110, a novel centrosomal substrate. Deregulation of Cep78 or EDD‐DYRK2‐DDB1VprBP perturbs CP110 ubiquitination and protein stability, thereby affecting centriole length and cilia assembly. Mechanistically, ubiquitination of CP110 entails its phosphorylation by DYRK2 and binding to VprBP. Cep78 specifically impedes the transfer of ubiquitin from EDD to CP110 without affecting CP110 phosphorylation and binding to VprBP. Thus, we identify Cep78 as a new player that regulates centrosome homeostasis by inhibiting the final step of the enzymatic reaction catalyzed by EDD‐DYRK2‐DDB1VprBP.
Propionibacterium acnes phylogenetic type III is associated with progressive macular hypomelanosis
Authors: Petersen Rolf L. W. , Scholz Christian F. P. , Jensen Anders , Brüggemann Holger , Lomholt Hans B. 
Published: February 2017

Progressive macular hypomelanosis (PMH) is a skin disorder that is characterized by hypopigmented macules and usually seen in young adults. The skin microbiota, in particular the bacterium Propionibacterium acnes, is suggested to play a role.
Here, we compared the P. acnes population of 24 PMH lesions from eight patients with corresponding nonlesional skin of the patients and matching control samples from eight healthy individuals using an unbiased, culture-independent next-generation sequencing approach. We also compared the P. acnes population before and after treatment with a combination of lymecycline and benzoylperoxide.
We found an association of one subtype of P. acnes, type III, with PMH. This type was predominant in all PMH lesions (73.9% of reads in average) but only detected as a minor proportion in matching control samples of healthy individuals (14.2% of reads in average). Strikingly, successful PMH treatment is able to alter the composition of the P. acnes population by substantially diminishing the proportion of P. acnes type III.
Our study suggests that P. acnes type III may play a role in the formation of PMH. Furthermore, it sheds light on substantial differences in the P. acnes phylotype distribution between the upper and lower back and abdomen in healthy individuals.
Primary single stage repair of newborn babies with pouch colon (anorectal malformation) in a tertiary setup
Authors: Aggarwal Sumeet , Aggarwal Amika , Ded K. S. 
Published: February 2017

Background: The standard procedure in the management of pouch colon is the staged procedure (SP), which has well-known disadvantages. We believe that staged procedure is unnecessary and single-stage procedure (SSP) can be done in the congenital pouch colon cases.Methods: Patients with pouch colon who underwent SSP (90 cases from 2008 to 2013) and SP (100 cases from 2003 to 2008), 65 and 55 of whom, respectively, were in regular follow-up for more than 3 years, were evaluated.Results: In SSP, male/female ratio was 87:3; in SP-94:6. Mean age of patient in SSP was 3.7 days and in SP 15 months. The distribution of cases into types I, II, III, and IV was 7, 16, 18, and 24 in SSP, and 6, 14, 15, and 20 in SP, respectively. The ratio of PSSP/SP for partial pouch colon (I and II) was 23:20 and for complete pouch colon (III and IV) was 42:35. The ratio of SSP/SP in terms of continence, mortality, and cost was 81:60, 17:53, and 1:6, respectively.Conclusions: Primary single-stage procedure gives better continence and cosmesis, with low morbidity and mortality at a low cost, and hence is recommended.
135th birth anniversary of Alexander Fleming (The beginning of the era of antibiotics is dedicated)
Authors: Andreev Alexandr Alexeevich , Ostroushko Anton Petrovich 
Published: February 2017

В 1999 году журнал «Time» включил Александра Флеминга в список 100 героев и кумиров XX века, заявив, что «открытие Флеминга породило огромную фармацевтическую промышленность, производящую синтетические пенициллины, направленные на борьбу с некоторыми самыми древними заболеваниями человечества, в числе которых сифилис, гангрена и туберкулез». По некоторым оценкам антибиотики спасли свыше 200 миллионов человек, а их открытие прибавило примерно 20 лет к средней продолжительности жизни человека в развитых странах.Александр Флеминг родился 6 августа 1881 года. В 1906 году получил степень Бакалавра Медицины и Бакалавра Хирургии с отличием и стал членом Королевского колледжа хирургов. В 1908 году он получает степень магистра и бакалавра наук в Лондонском университете. В 1922 году Александр Флеминг открывает лизоцим. В1928 г. он становится профессором бактериологии. 7 марта 1929 года, А. Флеминг выделил и описал свойства пенициллина. 12 февраля 1941 года пенициллин был впервые применен для лечения человека. В 1943 году началось промышленное производство антибиотика.В 1944 году Флеминг был возведен в рыцарское достоинство. В 1945 году Нобелевская премия по физиологии и медицине была присуждена А.Флемингу, Х.У.Флори и Э.Б.Чейну «за открытие пенициллина и его целебного воздействия при различных инфекционных болезнях». В 1928–1946 годах А. Флеминг работал профессором микробиологии Лондонского университета, в 1947 возглавил Институт Райта–Флеминга, в 1951–1954 был ректором Эдинбургского университета.А. Флеминг был удостоен 25 почетных степеней, 26 медалей, 18 премий, 30 наград и почетного членства в 89 академиях наук и научных обществах, в том числе, Лондонского королевского общества (1943), Парижской академии наук (1946), Первый президент общества общей микробиологии.Александр Флеминг скончался от инфаркта миокарда 11 марта 1955 года. В 2009 году изображение Флеминга размещено на новой купюре в 5 фунтов стерлингов.
Hypocholesterolemic effect of aqueous extract of the rhizomes of Sansevieria liberica on salt-loaded rats
Authors: Ikewuchi Jude C. , Ikewuchi Catherine C. , Ifeanacho Mercy O. , Igboh Ngozi M. , Ijeh Ifeoma I. , Ihunwo Stella A. 
Published: February 2017

In this study, the ability of an aqueous extract of the rhizomes of Sansevieria liberica to moderate plasma lipid profile and atherogenic indices was investigated in normal and sub-chronic salt-loaded rats. The normal and treatment control groups received a diet consisting 100% of the commercial feed, while the test control, reference and test treatment groups received an 8% salt-loaded diet. The extract was orally administered daily at 100 and 200 mg/kg body weight; while the moduretics was administered at 1 mg/kg body weight. The test control, reference and control groups received appropriate volumes of water by the same route. Compared to test control, the extract dose dependently significantly lowered (P<0.05) the plasma triglyceride, total-, very low density lipoprotein (VLDL)-, low density lipoprotein (LDL)- and non-high density lipoprotein (non-HDL) cholesterol levels, cardiac risk ratio, atherogenic coefficient and atherogenic index of plasma, while significantly (P<0.05) increasing the plasma high density lipoprotein (HDL) cholesterol concentration of the test animals. The present result highlighted the cardio-protective potential of the plant, and suggests its use in the management of dyslipidemia whether primary or secondary to obesity, diabetes mellitus and hypertension, and by extension, the reduction of the risk of cardiovascular diseases.
An overview of swine artificial insemination: Retrospective, current and prospective aspects
Authors: C. Soriano-Úbeda , C. Matás , FA García-Vázquez 
Published: February 2017

Assistant reproduction technologies are in constant evolution, among them the artificial insemination (AI). AI has been successfully used in pigs for decades, especially to improve boar efficienc and productivity. Lately, swine AI has taken on a new lease of life since efficient AI is essential for solving future challenges in the porcine industry and to enhance productivity. The present paper summarizes several factors concerning AI, starting with an overview of some physiological aspects including the female reproductive tract and sperm transport, as well as sperm losses during insemination and uterus sperm selection. Strategies developed to reduce the number of sperm during the AI process, are also reviewed, along with their combination with new reproductive technologies for application in pig production in the near future.
Efek Perbedaan Komposisi Konsentrat terhadap Perbaikan Nilai Nutrisi Jerami Padi
Authors: Widyawati Susi Dwi 
Published: February 2017

<p><em>Since rice straw is seasonal and low quality roughage, </em><em>thus, </em><em>a supplementation for it is needed. Lamtoro lea</em><em>f</em><em> meal (LLM) and soybean meal (SBM), hav</em><em>e</em><em> both soluble and bypass protein</em><em>, </em><em>so it enough potential to supply nutrients </em><em>to</em><em> optimize of rumen microbes and improv</em><em>e </em><em>animal performance. Supplementation with LLM or SBM significantly increase</em><em>d</em><em> dry matter, organic matter, crude protein and crude fiber intake (</em><em>P</em><em>&lt;0.05). This fact showed that LLM or SBM supplementation made an </em><em>improvement</em><em> of rumen fermentation by microbes. Comparison between LLM and SBM to basal diet clearly showed that basal diet </em><em>wa</em><em>s the lowest (</em><em>P</em><em>&lt;0.0</em><em>5</em><em>) nutrien</em><em>t</em><em> intake and nutrien</em><em>t</em><em> digestibility, however, the animal fed basal diet degraded crude fiber was not </em><em>affected</em><em>. It </em><em>has been shown that</em><em> sup</em><em>p</em><em>lementation with lamtoro lea</em><em>f</em><em> meal or soybean meal </em><em>we</em><em>re palatable, fermentable and reasonably digestible. </em><em>Therefore, the</em><em> use</em><em> of these feedstuffs</em><em> as supplement to rice straw </em><em>are</em><em> strongly recommended. </em></p><p><em> </em></p><p><strong><em>Key words</em></strong><em> : </em><em>concentrate</em><em>, PO beef cattle, </em><em>performance, </em><em>digestibility</em></p>
Pensamiento visible y currículo oculto
Authors: Santamaría Mondragón Billy 
Published: February 2017

Al recordar mi paso por el jardín infantil o la escuela primaria, no puedo dejar de decir que fue la época donde más momentos felices he acumulado, aunque también es la época donde más preguntas se han generado y solo hasta hoy ha sido posible responder. Nunca pude comprender, porque tenia que memorizar: las tablas de multiplicar, los distintos elementos químicos, el año en que Colombia logro su independencia, los colores primarios y secundarios, el año en que Cristóbal Colon “descubrió” o “invadió” a America y cuántos planetas conforman el sistema solar, entre otras cuestiones. Al despertar todos los días a las 5:50 a.m. para ir a la escuela, se suscitaban varias sensaciones y pensamientos, porque tenia que enfrentarme otra vez, a las mismas cuestiones (que para mi, le permitían al docente justificar su presencia en la escuela) y por otro lado, me generaba la mayor satisfacción, porque en dicho lugar me iba a encontrar de nuevo con mis amigos, para compartir juegos y risas.
A reflection on environmental awareness and the media in Fiji
Authors: Marsen Sky 
Published: February 2017

Issues of ‘failed’ nation-states, political meltdowns, coups and increasing militarisation have dogged the recent postcolonial history and environment of the Pacific. This, aside from the political and economic effects generally ascribed as the main societal impacts from such crises, has important social and cultural effects that are largely undocumented by academia as well as the media. The effects of political crisis on creativity through censorship, for example, are not adequately covered in current research and scholarship. The ‘Oceans and Nations: “Failed” States and the Environment in the Pacific’ symposium was organised concurrently with the Pacific Science Inter-Congress at the University of the South Pacific on 8-12 July 2013. This commentary and several other papers presented at this symposium are being published as part of this themed edition of Pacific Journalism Review. This article reflects on the role of the media in Fijians’ awareness, of environmental issues. It considers the question of whether local cultural and linguistic factors make the media a suitable source of information on the environment for Fijians, and proposes a method for future research that would help to answer this question.
‘Carbon colonialism’: Pacific environmental risk, media credibility and a deliberative perspective
Authors: Robie David 
Published: February 2017

The effects of climate change are already occurring in all continents and across the oceans, and the situation has deteriorated since the last account in 2007, warned the United Nations scientific agency charged with monitoring and assessing the risks earlier this year. According to the Intergovernmental Panel on Climate Change Fifth Assessment Report (IPCC, 2014), the world is ill-prepared to manage warming and an increase in magnitude is likely to lead to ‘severe and pervasive impacts that may be surprising or irreversible’. Seriously at risk are Small Island Developing States (SIDS), including several in the Pacific, such as Kiribati, Marshall Islands and Tuvalu. The UN has declared 2014 as the International Year of SIDS and a summit was hosted in Samoa during September. Living in one of the world’s most vulnerable regions to the impact of climate change and the challenges of aid effectiveness and adaptation funding, journalists are at a critical crossroads. This article examines environmental risk, media creativity and a contradiction between normative and traditional Western journalism values and the Pacific profession’s own challenges of ‘adaptation’ in telling the story of global warming with a deliberative perspective.Caption: Figure 2: Climate Change Warriors from Fiji: ‘We are not drowning. We are fighting.’ world.350.org/pacificwarriors/
Cybercrime, criminal libel and the media: From ‘e-martial law’ to the Magna Carta in the Philippines
Authors: Abcede Del , Robie David 
Published: February 2017

President Ferdinand E. Marcos declared martial law in the Philippines on 21 September 1972. Issuing the declaration under Proclamation 1081 which suspended civil rights, gagged the news media and imposed military authority in the country, Marcos defended this draconian move under the Philippines Constitution in response to a series of bombings allegedly caused by communist rebels. The emergency rule at the height of the Cold War was also planned to quell rebellion and drive national development. Four decades later, on 12 September 2012, President Benigno Aquino III signed Republic Act No. (RA) 10175, or the Cybercrime Prevention Act, into law. This legislation was immediately widely condemned as a threat to freedom of expression on the internet, the media and online privacy and has been likened by human rights groups, media freedom advocates, ‘netizens’ and opposition Congress members as comparable to the Marcos Martial Law era. Kabataan Representative Raymond Palatino branded the legislation ‘e-Martial Law’, comparing it to repressive Marcos-era decrees censoring and harassing the media. Fifteen Supreme Court appeal petitions were lodged against the Cybercrime Law but the subsequent ruling found the law constitutional in February 2014. This article examines the law, challenges since the constitutional ruling, and demands for repealing the law and replacing it with a so-called ‘Magna Carta’ of internet media freedom.Pictured: Figure 1: Protests against the Cybercrime Law have been widespread in the Philippines. Image: Interaksyon
Assessing the Coverage of E-Health Services in Sub-Saharan Africa
Authors: Adigun Taiwo , Misra Sanjay , Omoregbe Nicholas , Adeloye Davies 
Published: February 2017

SummaryBackground: E-Health has attracted growing interests globally. The relative lack of facilities, skills, funds and information on existing e-Health initiatives has affected progress on e-Health in Africa.Objectives: To review publicly available literature on e-Health in sub-Saharan Africa (sSA) towards providing information on existing and ongoing e-Health initiatives in the region.Methods: Searches of relevant literature were conducted on Medline, EMBASE and Global Health, with search dates set from 1990 to 2016. We included studies on e-Health initiatives (prototypes, designs, or completed projects) targeting population groups in sSA.Results: Our search returned 2322 hits, with 26 studies retained. Included studies were conducted in 14 countries across the four sub-regions in sSA (Central, East, South and West) and spreading over a 12-year period, 2002-2014. Six types of e-Health interventions were reported, with 17 studies (65%) based on telemedicine, followed by mHealth with 5 studies (19%). Other e-Health types include expert system, electronic medical records, e-mails, and online health module. Specific medical specialties covered include dermatology (19%), pathology (12%) and radiology (8%). Successes were ‘widely reported’ (representing 50% overall acceptance or positive feedbacks in a study) in 10 studies (38%). The prominent challenges reported were technical problems, poor internet and connectivity, participants’ selection biases, contextual issues, and lack of funds.Conclusion: E-Health is evolving in sSA, but with poorly published evidence. While we call for more quality research in the region, it is also important that population-wide policies and on-going e-Health initiatives are contex- tually feasible, acceptable, and sustainable.