bluuebunny/crossref_metadata_2025_split huggingface dataset:
A scoping review of online repositories of quality improvement projects, interventions and initiatives in healthcare
Authors: Bytautas Jessica P , Gheihman Galina , Dobrow Mark J 
Published: April 2016

BackgroundQuality improvement (QI) is becoming an important focal point for health systems. There is increasing interest among health system stakeholders to learn from and share experiences on the use of QI methods and approaches in their work. Yet there are few easily accessible, online repositories dedicated to documenting QI activity.MethodsWe conducted a scoping review of publicly available, web-based QI repositories to (i) identify current approaches to sharing information on QI practices; (ii) categorise these approaches based on hosting, scope and size, content acquisition and eligibility, content format and search, and evaluation and engagement characteristics; and (iii) review evaluations of the design, usefulness and impact of their online QI practice repositories. The search strategy consisted of traditional database and grey literature searches, as well as expert consultation, with the ultimate aim of identifying and describing QI repositories of practices undertaken in a healthcare context.ResultsWe identified 13 QI repositories and found substantial variation across the five categories. The QI repositories used different terminology (eg, practices vs case studies) and approaches to content acquisition, and varied in terms of primary areas of focus. All provided some means for organising content according to categories or themes and most provided at least rudimentary keyword search functionality. Notably, none of the QI repositories included evaluations of their impact.DiscussionWith growing interest in sharing and spreading best practices and increasing reliance on QI as a key contributor to health system performance, the role of QI repositories is likely to expand. Designing future QI repositories based on knowledge of the range and type of features available is an important starting point for improving their usefulness and impact.
Progesterone therapy for the treatment of non-cancer cachexia: a systematic review
Authors: Taylor Joanne K , Pendleton Neil 
Published: April 2016

BackgroundCachexia describes a complex pathological syndrome of muscle wasting, anorexia and weight loss. Progesterone therapies have been shown to improve appetite and promote weight gain in patients with cachexia; however, research has focused heavily on patients with cancer, and its effectiveness in other diseases remains unclear.AimsThis systematic review aimed to present the evidence available for progesterone therapy as a treatment for non-cancer cachexia.MethodSurrogate outcome measures used were weight change, lean body mass (LBM), muscle strength, appetite, health-related quality of life (HRQOL) and serum albumin. Both randomised and non-randomised trials were included. A literature search of clinical trials using the medical subject heading (MeSH) terms ‘cachexia’ OR ‘anorexia’ OR ‘weight’ OR ‘frail (truncated)’ OR ‘appetite’ OR ‘wasting syndrome’ PLUS ‘megestrol acetate’ OR ‘medroxyprogesterone acetate’ was performed.ResultsEighteen studies were included in this review; 12 randomised control trials and 6 non-randomised trials. This collated results from 916 patients with HIV/AIDS, end-stage renal failure, chronic obstructive pulmonary disease (COPD) and geriatric cachexia. Meta-analysis comparing progesterone therapy with placebo concluded mean change in weight was not significant (mean difference (MD) 1.56, 95% CI −0.36 to 3.52, p=0.12). There was little evidence to show significant impact on LBM, and no trials looked at muscle strength. There was a paucity of evidence looking at appetite and HRQOL; however, results were generally positive.ConclusionsCurrent evidence does not support the use of progesterone therapies for non-cancer cachexia. There may however be a limited role for its use as an appetite stimulant in a palliative context on a case-by-case basis.
Performance analysis of junctionless carbon nanotube field effect transistors using NEGF formalism
Authors: Barbastegan Saber , Shahhoseini Ali 
Published: April 2016

This paper presents the simulation study of a junctionless carbon nanotube field effect transistor (JL-CNTFET) and a comparison is made with the conventional CNTFET using the atomistic scale simulation, within the non-equilibrium Green’s function (NEGF) formalism. In order to have a comprehensive analysis, both analog and digital parameters of the device are studied. Results have shown that JL-CNTFET with respect to C-CNTFET shows slightly higher [Formula: see text] ratio about two times larger than that of C-CNTFET, smaller electric field along channel more than three order of magnitude and reduced tunneling current about 100 times. In addition, the investigation of analog properties of both devices has exhibited that junctionless structure has a transconductance about two times and an intrinsic gain of 15 dB larger than C-CNTFET in same bias condition which makes JL-CNTFET a promising candidate for low voltage analog applications.
Distinct Effects of Adipose-Derived Stem Cells and Adipocytes on Normal and Cancer Cell Hierarchy
Authors: Anjanappa Manjushree , Burnett Riesa , Zieger Michael A. , Merfeld-Clauss Stephanie , Wooden William , March Keith , Tholpady Sunil , Nakshatri Harikrishna 
Published: April 2016

Abstract
Adipose-derived stem cells (ASC) have received considerable attention in oncology because of the known direct link between obesity and cancer as well as the use of ASCs in reconstructive surgery after tumor ablation. Previous studies have documented how cancer cells commandeer ASCs to support their survival by altering extracellular matrix composition and stiffness, migration, and metastasis. This study focused on delineating the effects of ASCs and adipocytes on the self-renewal of stem/progenitor cells and hierarchy of breast epithelial cells. The immortalized breast epithelial cell line MCF10A, ductal carcinoma in situ (DCIS) cell lines MCF10DCIS.com and SUM225, and MCF10A-overexpressing SRC oncogene were examined using a mammosphere assay and flow cytometry for the effects of ASCs on their self-renewal and stem-luminal progenitor-differentiated cell surface marker profiles. Interestingly, ASCs promoted the self-renewal of all cell types except SUM225. ASC coculture or treatment with ASC conditioned media altered the number of CD49fhigh/EpCAMlow basal/stem-like and CD49fmedium/EpCAMmedium luminal progenitor cells. Among multiple factors secreted by ASCs, IFNγ and hepatocyte growth factor (HGF) displayed unique actions on epithelial cell hierarchy. IFNγ increased stem/progenitor-like cells while simultaneously reducing the size of mammospheres, whereas HGF increased the size of mammospheres with an accompanying increase in luminal progenitor cells. ASCs expressed higher levels of HGF, whereas adipocytes expressed higher levels of IFNγ. As luminal progenitor cells are believed to be prone for transformation, IFNγ and HGF expression status of ASCs may influence susceptibility for developing breast cancer as well as on outcomes of autologous fat transplantation on residual/dormant tumor cells.
Implications: This study suggests that the ratio of ASCs to adipocytes influences cancer cell hierarchy, which may impact incidence and progression. Mol Cancer Res; 14(7); 660–71. ©2016 AACR.
Dual anti-platelet therapy after coronary drug-eluting stent implantation and surgery-associated major adverse events
Authors: Egholm Gro , Thim Troels , Olesen Kevin , Madsen Morten , Sorensen Henrik , Jensen Svend , Jensen Lisette , Botker Hans , Kristensen Steen , Maeng Michael 
Published: April 2016

SummarySurgery may necessitate interruption of dual antiplatelet therapy (DAPT) within the first year after coronary drug-eluting stent (DES) implantation. We conducted a population-based cohort study to assess the rate of surgery within the first year after DES implantation, surgery-associated major adverse cardiac events (MACE), reoperation for bleeding within 30 days after surgery, and two nested case-control analyses to explore any association between preoperative antiplatelet therapy, MACE, and reoperation for bleeding. In the cohort of 22,654 patients treated with DES, 1,944 patients (8.6 %) underwent moderate- to high-risk surgery within 12 months. Of these, 62 (3.2 %) experienced MACE and 54 (2.8 %) needed reoperation for bleeding within 30 days. In the nested case-control analyses of 458 cases and controls, where 70 % (n=324) had a first generation DES, absence of preoperative antiplatelet therapy was associated with an increased MACE rate (OR 2.36, 95 % CI 1.02–5.48) compared to single antiplatelet therapy (SAPT) or DAPT. Preoperative SAPT versus DAPT showed no difference in MACE rates (OR 0.85, 95 % CI 0.30–2.40). Surgery within the first month was associated with increased MACE rate (OR 4.67, 95 % CI 2.22–9.83) compared to surgery 2–12 months after DES implantation. Absence of preoperative antiplatelet therapy did not reduce reoperation for bleeding as compared to patients on SAPT or DAPT (OR 1.32, 95 % CI 0.56–3.12). In conclusion, absence of preoperative antiplatelet therapy and surgery within the first month after DES implantation were associated with increased MACE rates.
Akcentuacja zapożyczonych leksemów czasownikowych w gwarze staroobrzędowców mieszkających w regionie suwalsko-augustowskim
Authors: Paśko-Koneczniak Dorota Angelika 
Published: April 2016

Stress patterns in loan verb lexemes in the dialect used by the Old Believers living in the Suwałki-Augustów region The aim of the article is to present the stress pattern phenomenon in loan verb lexemes which function in the Russian dialect of the Old Believers from the Suwałki-Augustów Region. In the last decades, the insular dialect, separated from the general Russian language, has been influenced by the Polish language. Such influence is visible, in particular, in the vocabulary, in the form of loan translations and idiomatic expressions. Stress patterns, along with the root vocabulary and the morphological system, still remains one of the indicators of the Russian essence of the dialect. The native vocabulary of the Old Believers’ dialect maintains Russian accentuation patterns. A similar situation is observed in the case of stress patterns in lexemes borrowed from Polish, which undergo a stress accentuation adaptation; that is, they feature a shift in the place of the stress in relation to the source language. In loan verb morphemes, one can notice the pattern of stress which is not fixed and depends upon the morphological form or, sometimes, the paroxitonic stress, which results from the influence of the Polish language. Akcentuacja zapożyczonych leksemów czasownikowych w gwarze staroobrzędowców mieszkających w regionie suwalsko-augustowskim Celem artykułu jest zaprezentowanie zjawiska akcentuacji w zapożyczonych leksemach czasownikowych, funkcjonujących w rosyjskiej gwarze staroobrzędowców z regionu suwalsko-augustowskiego. W ciągu ostatnich kilkudziesięciu lat badana gwara wyspowa, odseparowana od rosyjskiego języka ogólnego, podlega znacznemu wpływowi języka polskiego. Wpływ polszczyzny widoczny jest szczególnie w zasobie leksykalnym w postaci zapożyczeń, kalk i w idiomatyce. Akcentuacja obok rdzennego zasobu leksykalnego i systemu morfologicznego nadal pozostaje jednym z wyznaczników rosyjskości gwary. Rodzimy zasób leksykalny badanej gwary staroobrzędowców zachowuje rosyjski system akcentuacyjny. Podobnie rzecz się ma z systemem akcentuacyjnym w leksemach zapożyczonych z języka polskiego, które podlegają adaptacji akcentuacyjnej, czyli następuje w nich przesunięcie miejsca akcentu w stosunku do języka dawcy. W zapożyczonych leksemach czasownikowych mamy do czynienia ze zmiennością akcentu uzależnioną od formy morfologicznej, niekiedy również z akcentem paroksytonicznym, wynikającym z wpływu języka polskiego.
Regional Changes in the Interannual Variability of U.S. Warm Season Precipitation
Authors: Weaver Scott J. , Baxter Stephen , Harnos Kirstin 
Published: April 2016

Abstract
Intensification of regional springtime precipitation variability over the United States and the role of North American low-level jets (NALLJs) are investigated for the 1950–2010 period. The analysis reveals that the primary modes of NALLJ fluctuations are related to the strengthening of AMJ precipitation variability over the northern Great Plains and southeastern United States during the last 60 years. Examination of the epochal change in NALLJ variations shows a stronger connectivity to SST variability during 1980–2010 than in the 1950–79 period. In the context of the first three NALLJ variability modes it appears that the role of decadal SST variations (NALLJ mode 1) and the recent emergence of tropical Pacific connectivity (NALLJ modes 1 and 2) via SST-induced atmospheric heating and large-scale circulation changes may act to strengthen and spatially shift the NALLJ variability modes southward and/or eastward, intensifying regional precipitation variability in the recent epoch. Although notable NALLJ variability also exists in the earlier epoch, the upper-level height field is significantly lacking in meridional gradients, leading to weak upper-level zonal wind anomalies over the United States and diminished NALLJ variability. Conversely, the intensified and spatially shifted upper-level height anomaly in the recent epoch produces enhanced meridional height gradients in all three modes, strengthening NALLJ variability—highlighting that seemingly subtle shifts in hemispheric-scale atmospheric circulation changes can have important impacts on regional climate variability and change.
Eustachian Tube Bypass: Experimental Evidence for Total Eustachian Tube Substitution
Authors: Lapidot Abraham , Terrefe Dessaglegn , Rezvani Firooz , Hough Aubrey J. 
Published: April 2016

Several preliminary reports have appeared in the medical literature in respect to eustachian tube substitution1–6 since Zollner7 first described his inability to open the obstructed eustachian tube. These procedures3,5,6 have the disadvantage that the distal end of the eustachian tube substitute is inaccessible by other than another operation.This paper is a follow‐up report to our clinical experience.2 The purpose of the experiment was to determine whether the middle ear was ventilated by the tympano‐oropharyngeal substitute eustachian tube and whether ascending infection occurred.Fourteen ears underwent eustachian tube substitution. The natural eustachian tubes of these ears were obliterated three to five months after eustachian tube substitution had been performed. The animals were killed three to four months after obliteration of the natural eustachian tubes. Studies of the decalcified sections showed an absence of infection in six of the ears, with mild to severe inflammation in the rest of the specimens.
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
Authors: Uras Iris Z. , Walter Gina J. , Scheicher Ruth , Bellutti Florian , Prchal-Murphy Michaela , Tigan Anca S. , Valent Peter , Heidel Florian H. , Kubicek Stefan , Scholl Claudia , Fröhling Stefan , Sexl Veronika 
Published: April 2016

Key Points
CDK6 directly regulates transcription of FLT3 and PIM1 in a kinase-dependent manner. CDK6 kinase inhibition impairs not only FLT3-dependent cell growth in vitro but also FLT3-driven leukemogenesis in vivo.
Expression and specific activities of carbamoyl phosphate synthetase 1 in chronic hypoxic rats
Authors: Nikmah Uly A. , Prijanti Ani R. , Jusman Sri W.A. , Sadikin Mohamad 
Published: April 2016

Background: Urea biosynthesis is a very important process in the liver which needs ATP, CO2 and functional mitochondria or aerobic condition. Liver can adapt to hypoxic condition, generally and locally. This study aimed to analyze the effect of chronic hypoxia on liver urea biosynthesis as indicated by the level and specific activity of mRNA of carbamoyl phosphate synthetase 1 (CPS1), a key enzyme in urea biosynthesis in hypoxic rats.Methods: 20 male Sprague-Dawley rats were placed in hypoxic chamber supplied by a mixture of 10% O2 and 90% N2. Five rats were sacrificed at 1, 3, 5, and 7 days after exposure. Liver homogenates were analyzed for HIF-1 (hypoxia inducible factor-1) by ELISA, CPS1 mRNA by real time RT-PCR and CPS1 enzymatic specific activities by Pierson method. Data were analyzed by ANOVA test and Pearson correlation.Results: The HIF-1 in liver increased significantly, as well as CPS1 mRNA and CPS1 enzymatic activities (p<0.05). There was a strong correlation (r=0.618; p<0.01) between the level of CPS1 mRNA and CPS1 enzymatic activities, moderate correlation between HIF-1 and CPS1 mRNA (r=0.419; p<0.05) but no correlation between HIF-1 and CPS1 enzymatic activities. The study indicated that urea biosynthesis in liver was affected by hypoxia and partially under HIF-1 regulation. The study also found increase of urea and NH3 biosynthesis related to proteolysis as indicated by the decrease of total body weight and liver weight.Conclusion: There was an increase in the expression and specific activities of CPS1 in urea biosynthesis as a result of increasing proteolysis in chronic hypoxic condition.
X-ray radiation effect of C-arm on adipose tissue-mesenchymal stem cell viability and population doubling time
Authors: Rahyussalim Ahmad J. , Pawitan Jeanne A. , Kusnadi Alam R. , Kurniawati Tri 
Published: April 2016

Background: Adipose tissue derived mesenchymal stem cells (AT-MSCs) are relatively easy in isolation procedure compared to bone marrow-derived. Minimally invasive MSC injections need C-arm as guidance that potentially influence the cell viability and doubling time. This study aimsed to determine the effect of C-arm X-ray exposure on AT-MSC viability and population doubling time (PDT).Methods: This experimental study used cryopreserved adipose tissue derived MSCs stored in Stem Cell Medical Technology Integrated Service Unit Cipto Mangunkusumo Hospital. Cells were thawed, propagated, and exposed to varying doses of C-arm X-ray radiation. Stem cell viability was measured, and then the cells were cultured to assess their PDT. Generalized linear models test was used to compare cell viability between post-thaw, post-propagation, post-radiation, post-culture post-radiation, and control and between radiation dose groups. Kruskal-Wallis test assessed PDT between various radiation doses in post-radiation groups. Wilcoxon test was used to assess PDT between pre-radiation and post-radiation groups.Results: Mean confluence period of adipose MSCs post- irradiation was 4.33 days. There was no statistically significant difference in MSC viability after X-ray exposure between pre- and post-irradiation groups (p=0.831). There was no correlation between post-irradiation viability and radiation dose (p=0.138, r=0.503). There were no significant differences in PDT between pre- and post-culture post-irradiation groups and between various radiation doses in post-irradiation groups (p=0.792). Conclusion: MSC viability and PDT were not influenced by radiation exposure up to 32.34 mgray.
Representações da Violência por Professores
Authors: Carvalho Maria Das Graças de , Oliveira Gislene Farias de , Carita Ana 
Published: April 2016

A violência no espaço escolar tem sido motivo de preocupação em todo o mundo. O objetivo foi analisar a violência no espaço escolar, à partir da percepção dos professores no município de Simões-PI. Fizeram parte da amostra, 49 docentes, sendo 77,6% mulheres e 22,4% homens. Desses, 98,0% observaram episódios de violência na escola, sendo o tipo mais comum, a patrimonial 28,5%, seguida da física 27,2%; da negligência 22,8% e da psicológica em 21,0% dos casos. Dentre as modalidades mais citadas estiveram presentes nas respostas, a Intimidação (40,8%); a Difamação (16,3%); o Assédio moral (12,2%); a Injúria (4,1%) e, outras (26,5%). Com relação ao local onde foram observadas as violências, Foram citados: Dentro da Escola 40 (81,6%); Na rua 3 (6,1%); Outro lugar 2 (4,1%); Não responderam a esta questão 4 (8,2%). Quanto às Representações sociais de Violência, sobressaiu-se uma única categoria: Ação maléfica. O estudo concluiu que a violência no ambiente escolar ainda necessita ser mais discutida, para que se possa conhecer aspectos associados às diversas variáveis implicadas, não demonstradas no presente estudo. Nesse sentido evidencia-se a importância que se deva dar para a identificação dos possíveis casos de problemas acadêmicos, visando prevenir-se a tempo, as situações de risco.
Poesia e letramento Literário no Ensino Fundamental
Authors: Nunes Ginete Cavalcante 
Published: April 2016

O presente trabalho tem como objetivo apresentar algumas considerações a respeito do trabalho em sala de aula com a poesia e quão significativo pode ser o trabalho com esse gênero, pois, na maioria das vezes o poema acaba sendo trabalhado , como pretexto para análise gramatical ou questionamentos sobre seu aspecto formal .Para discorremos sobre o tema temos como base teórica os trabalhos de Bosi (1977 e 1996), Bakhtin (1997), Barthes(1988),Cosson(2006 e 2014) Cunha (2012), Eagleton (2006), Jouve (2012), Lajolo (1982 e 2000), Pinheiro(2002), Sorrenti (2007), Todorov(2009), Zilberman (1988 e 2003), Zumthor (2007), entre outros,na perspectiva de promover estratégias que aprimorem o ensino da Literatura e de propor livros que despertem o interesse dos alunos pela leitura, este texto justifica-se por tornar possíveis percepções sobre questões do ensino do poema e práticas docentes em literatura mais precisamente com o trabalho com o texto literário, pois este transgride normas, desconstrói a própria linguagem e inaugura mundos possíveis, por meio da transfiguração do real e que desta maneira nos inagamos:Como o uso dos poemas pode influenciar e promover a leitura literária dos alunos do 9º ano do ensino fundamental? Nosso interesse em investigar o referido assunto também justifica-se pela tentativa de contribuir com os debates a respeito do uso de textos literários e dos livros didáticos de Português no ensino de literatura, promovendo assim o letramento literário, práticas estas norteadas por relações muito complexas, que carecem de estudos, reflexões e discussões.
Análise dos Conceitos de poder Disciplinar e Biopoder em Foucault
Authors: Sobral Maria do Socorro Cecílio , Oliveira Sidney Medeiros de 
Published: April 2016

O presente trabalho é uma resenha da obra “Foucault, para além do poder disciplinar e do biopoder” de Thamy Pogrebinschi. Escreve sobre um dos maiores filósofos contemporâneos, sobre as categorias do poder disciplinar e do biopoder, cujo argumento versa sobre a diferenciação do poder da idéia de repressão , de lei, aproximando-o de algo mais produtivo, positivo e emancipatório.
Reflexão da Prática Pedagógica na perspectiva de uma Formação Docente Contextualizada
Authors: Alves Maria Aparecida Oliveira , Oliveira Gislene Farias de 
Published: April 2016

A formação docente constitui-se um processo contínuo e inacabado, portanto, o professor deve está inserido no processo permanente de desenvolvimento profissional no qual a reflexão seja uma exigência para o fazer docente, uma vez que, uma prática reflexiva é profícua na construção de novos conhecimentos e, influencia positivamente na qualidade da ação pedagógica de um professor. O presente artigo é resultado de uma pesquisa bibliográfica integrativa da literatura. Enfatiza a formação docente como um fator-chave para a realização de um ensino com qualidade. Tem como objetivo refletir sobre a importância do professor se adequar e atender às novas exigências da sociedade contemporânea que requer profissionais críticos, reflexivos e investigadores capazes de realizar ações criativas e contextualizadas. Nessa perspectiva, é preciso a implementação de políticas educacionais que valorizem o magistério, que incidam em melhores investimentos de modo que os discursos nesse sentido sejam transformados em ações mais efetivas.