bluuebunny/crossref_metadata_2025_split huggingface dataset:
An ultra thin polarization insensitive and angularly stable miniaturized frequency selective surface
Authors: Varuna A.B. , Ghosh Saptarshi , Srivastava Kumar Vaibhav 
Published: August 2016

ABSTRACTIn this article, a novel polarization‐insensitive and angularly stable miniaturized frequency selective surface (FSS) has been presented. The proposed structure has a single bandpass operation centred at 1.42 GHz, which is printed on an ultra‐thin (0.00127λ0) dielectric substrate. Compared with earlier reported structures, the designed FSS demonstrates a better miniaturization performance having unit cell dimension of 0.0378λ0 × 0.0378λ0, where λ0 refers to free space wavelength corresponding to resonant frequency. Furthermore, an equivalent circuit model has been derived whose circuit simulation matches well with the full‐wave analysis. Finally, a prototype of proposed FSS is fabricated and the measured responses are in good agreement with the simulated results under normal as well as oblique incidence. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2713–2717, 2016
Corrugated conical horn antenna with wide beamwidth at 60 GHz band
Authors: OrihuelaVargas Carlos E. , Coelho Fabiano V.S. , Siqueira Glaucio L. , Magri Vanessa P.R. , Matos Leni J. 
Published: August 2016

ABSTRACTTwo 90‐degree conical horn antennas prototypes were designed and characterized to achieve wide beamwidth at 60 GHz in order to receive multipath signals in a mobile environment. The antennas consist of a circular waveguide and a flange with one and three annular slots. A simulated half‐power beamwidth of 112 degrees was reached for the antenna with one annular slot and 115 degrees for the antenna with three annular slots. Some tests were realized and the results compared with the simulated ones showing good agreement.© 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2731–2738, 2016
Design of a 75–110‐GHz millimeter‐wave 90‐nm CMOS highly isolated transmitter/receiver switch by leakage‐cancellation technique
Authors: Chou Chien‐Chang , Huang Shih‐Chiao , Lai Wen‐Chian , Kuo H.‐C. , Chuang Huey‐Ru 
Published: August 2016

ABSTRACTThis article presents 75‐110‐GHz highly isolated T/R switch in 90nm CMOS. The proposed T/R switch circuit design is focused on highly isolation performance which is achieved by using both parallel inductors and leakage‐cancellation techniques. To also reduce insertion loss which is also an important design key point, series‐shunt single‐pole double throw (SPDT) switch with optimizing transistors size and body‐floating technique are adopted. From the experiment results, the designed switch has good performance of the return loss, insertion loss and isolation in W‐band. Compared with some previously reported works, the designed switch has the best isolation performance of 48 dB at 94‐GHz, and IP1dB is > 9dBm, respectively.© 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2725–2731, 2016
A laguerre‐based time‐domain discontinuous Galerkin finite element‐boundary integral method
Authors: Tian Cheng‐Yi , Shi Yan , Liu Zhi‐Qi , Liang Chang‐Hong 
Published: August 2016

ABSTRACTThis article develops a Laguerre‐based discontinuous Galerkin finite element‐boundary integral method for solving Maxwell's equations in the time domain. A set of hierarchical vector functions and weighted Laguerre polynomials as spatial and temporal basis functions are used to expand transient electromagnetic fields, respectively. The electromagnetic fields at truncated boundary are solved by the time‐domain boundary integral method and used in the partial penalized numerical flux in the discontinuous Galerkin time‐domain method, thus avoiding the use of absorbing boundary condition. With the use of the Galerkin temporal testing procedure, the Laguerre‐based algorithm eliminates the time variable, and hence the explicit time integration solution procedure is replaced by a recursive solution procedure in terms of the orders of temporal testing functions. The use of the partial penalized numerical flux with an optimized penalty factor can improve the accuracy of the proposed algorithm compared with the widely used central flux and upwind flux. Numerical results demonstrate that the proposed method becomes increasingly accurate with increase of the order of the spatial basis functions.© 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2774–2780, 2016
Implantable ferrite antenna for biomedical applications
Authors: Fazeli Maxwell , Hong Yang‐Ki , Lee Woncheol , Park Jihoon 
Published: August 2016

ABSTRACTWe have developed a miniaturized implantable ferrite antenna, operating in the industrial, scientific, and medical band (2.4–2.5 GHz). The dip‐coated NiCo ferrite films effectively reduces the antenna resonance by 110 MHz, with a 4.2 dB reflection coefficient improvement as compared with an antenna without ferrite. The ferrite antenna also reveals a 6 dBi and 35 MHz improvement in realized gain and −10 dB bandwidth, respectively, at resonance. The effects of ferrite film loading on antenna performance are further investigated with parametric simulations and experimental comparisons.© 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2745–2749, 2016
Cigarette Smoking Is Associated With Cubital Tunnel Syndrome
Authors: Suzuki Taku , Iwamoto Takuji , Ochi Kensuke , Mito Kazuaki , Nakamura Toshiyasu , Suzuki Katsuji , Yamada Harumoto , Sato Kazuki 
Published: August 2016

ABSTRACTIntroductionThe aim of this study was to validate the potential association between cigarette smoking and cubital tunnel syndrome (CubTS).MethodsOne hundred patients with CubTS were compared with 100 controls with ulnar abutment syndrome matched for age, gender, and body mass index. The smoking status was compared between patients and controls using the sign test and the Wilcoxon signed rank test. Conditional logistic regression was used to calculate the association between CubTS and pack‐years smoked.ResultsA significant association was found between increased pack‐years smoked and CubTS. A significant difference in the number of never smokers and ever smokers was observed between the patients with CubTS and controls. The difference in mean pack‐years in the patients and controls was highly significant. A dose‐dependent association with pack‐years was found between patients and controls.ConclusionsHigh cumulative cigarette smoking is associated with CubTS. Muscle Nerve 54: 1136–1138, 2016
Comparative study of peripheral nerve Mri and ultrasound in multifocal motor neuropathy and amyotrophic lateral sclerosis
Authors: Jongbloed Bas A. , Haakma Wieke , Goedee H. Stephan , Bos Jeroen W. , Bos Clemens , Hendrikse Jeroen , Van Den Berg Leonard H. , Van Der Pol W. Ludo 
Published: August 2016

ABSTRACTIntroduction: Differentiating multifocal motor neuropathy (MMN) from amyotrophic lateral sclerosis (ALS) is important, as MMN is a difficult, but treatable disorder. Methods: We studied peripheral nerve imaging techniques in differentiating MMN from ALS by measuring the cross‐sectional area (CSA) of the median and ulnar nerves in the forearms using high resolution ultrasound (HRUS) and MRI. Results: HRUS CSA values of the median nerve in the forearm (P = 0.002) and the ulnar nerve distal to the sulcus (P = 0.009) were significantly enlarged in patients with MMN. There was a positive correlation between CSA as measured with HRUS and MRI (Spearman rho 0.60; P < 0.001). Conclusions: Peripheral nerve imaging is a potentially powerful technique to distinguish MMN from ALS. Muscle Nerve, 2016 Muscle Nerve 54: 1133–1135, 2016
A local RBF collocation method for band structure computations of 2D solid/fluid and fluid/solid phononic crystals
Authors: Zheng Hui , Zhang Chuanzeng , Wang Yuesheng , Chen Wen , Sladek Jan , Sladek Vladimir 
Published: August 2016

SummaryIn this paper, an efficient local radial basis function collocation method (LRBFCM) is presented for computing the band structures of the two‐dimensional (2D) solid/fluid and fluid/solid phononic crystals. Both systems of solid scatterers embedded in a fluid matrix (solid/fluid phononic crystals) and fluid scatterers embedded in a solid matrix (fluid/solid phononic crystals) are investigated. The solid–fluid interactions are taken into account by properly formulating and treating the continuity/equilibrium conditions on the solid–fluid interfaces, which require an accurate computation of the normal derivatives of the displacements and the pressure on the fluid–solid interfaces and the unit‐cell boundaries. The developed LRBFCM for the mixed wave propagation problems in 2D solid/fluid and fluid/solid phononic crystals is validated by the corresponding results obtained by the finite element method (FEM). To the best knowledge of the authors, the present LRBFCM has yet not been applied to the band structure computations of 2D solid/fluid and fluid/solid phononic crystals. For different lattice forms, scatterers' shapes, acoustic impedance ratios, and material combinations (solid scatterers in fluid matrix or fluid scatterers in solid matrix), numerical results are presented and discussed to reveal the efficiency and the accuracy of the developed LRBFCM for calculating the band structures of 2D solid/fluid and fluid/solid phononic crystals. A comparison of the present numerical results with that of the FEM shows that the present LRBFCM is much more efficient than the FEM for the band structure computations of the considered 2D solid/fluid and fluid/solid phononic crystals. Copyright © 2016 John Wiley & Sons, Ltd.
The genetic architecture of body mass index from infancy to adulthood modified by parental education
Authors: Silventoinen Karri , Huppertz Charlotte , van Beijsterveldt Catharina E.M. , Bartels Meike , Willemsen Gonneke , Boomsma Dorret I. 
Published: August 2016

ObjectiveA higher prevalence of obesity in lower socioeconomic classes is common in Western societies. This study examined the role of gene–environment interactions in the association between parental education and body mass index (BMI) from infancy to the onset of adulthood.MethodsParentally reported BMI from 1 to 13 and self‐reported BMI from 14 to 20 years of age were collected in 16,646 complete Dutch twin pairs and analyzed by genetic twin modeling.ResultsAt 7 to 8 years of age, children whose parents had middle or low educational levels had more excess weight than the children of more highly educated parents, and the difference increased until 18 to 20 years of age. The major part of the BMI variation was explained by additive genetic factors (a2 = 0.55–0.85), but environmental factors common for co‐twins also played a significant role, especially from 3 to 7–8 years of age (c2 = 0.15–0.29). The genetic variation in BMI was higher in children whose parents had middle or low educational levels compared with children whose parents had a high educational level.ConclusionsThe interaction between genetic factors and the childhood social environment may contribute to the formation of socioeconomic differences in obesity.
Body mass index and all‐cause mortality among older adults
Authors: Cheng Feon W. , Gao Xiang , Mitchell Diane C. , Wood Craig , Still Christopher D. , Rolston David , Jensen Gordon L. 
Published: August 2016

ObjectiveTo examine the association between baseline body mass index (BMI, kg/m2) and all‐cause mortality in a well‐characterized cohort of older persons.MethodsThe association between BMI (both as a categorical and continuous variable) and all‐cause mortality was investigated using 4,565 Geisinger Rural Aging Study participants with baseline age 74.0 ± 4.7 years (mean ± SD) and BMI 29.5 ± 5.3 kg/m2 over a mean of 10.9 ± 3.8 years of follow‐up.ResultsThe relationship between BMI (as a continuous variable) and all‐cause mortality was found to be U‐shaped (P nonlinearity <0.001). Controlling for age, sex, smoking, alcohol, laboratory values, medications, and comorbidity status, underweight (BMI <18.5 kg/m2) individuals had significantly greater adjusted risk of all‐cause mortality than persons of BMI 18.5 to 24.9 kg/m2 (reference range). Participants with overweight (BMI 25.0–29.9 kg/m2) and class I obesity (BMI 30.0–34.9 kg/m2) had significantly lower adjusted‐risk of all‐cause mortality. Those with classes II/III obesity (BMI ≥ 35.0 kg/m2) did not have significantly greater adjusted‐risk of all‐cause mortality. Findings were consistent using propensity score weights and among never‐smokers with 2‐ and 5‐year lag analysis and among those with no identified chronic disease.ConclusionsA U‐shaped association was observed between BMI and all‐cause mortality with lower risk among older persons with overweight and class I obesity in comparison with those with BMI 18.5 to 24.9 kg/m2.
Connexin 43 is overexpressed in human fetal membrane defects after fetoscopic surgery
Authors: Barrett David W. , David Anna L. , Thrasivoulou Christopher , Mata Alvaro , Becker David L. , Engels Alex C. , Deprest Jan A. , Chowdhury Tina T. 
Published: August 2016

AbstractObjectiveWe examined whether surgically induced membrane defects elevate connexin 43 (Cx43) expression in the wound edge of the amniotic membrane (AM) and drives structural changes in collagen that affects healing after fetoscopic surgery.MethodCell morphology and collagen microstructure was investigated by scanning electron microscopy and second harmonic generation in fetal membranes taken from women who underwent fetal surgery. Immunofluoresence and real‐time quantitative polymerase chain reaction was used to examine Cx43 expression in control and wound edge AM.ResultsScanning electron microscopy showed dense, helical patterns of collagen fibrils in the wound edge of the fetal membrane. This arrangement changed in the fibroblast layer with evidence of collagen fibrils that were highly polarised along the wound edge but not in control membranes. Cx43 was increased by 112.9% in wound edge AM compared with controls (p < 0.001), with preferential distribution in the fibroblast layer compared with the epithelial layer (p < 0.01). In wound edge AM, mesenchymal cells had a flattened morphology, and there was evidence of poor epithelial migration across the defect. Cx43 and COX‐2 expression was significantly increased in wound edge AM compared with controls (p < 0.001).ConclusionOverexpression of Cx43 in the AM after fetal surgery induces morphological and structural changes in the collagenous matrix that may interfere with normal healing mechanisms. © 2016 The Authors. Prenatal Diagnosis published by John Wiley & Sons, Ltd.
Technical feasibility and safety of an intraoperative head‐up display device during spine instrumentation
Authors: Yoon Jang W. , Chen Robert E. , Han Phillip K. , Si Phong , Freeman William D. , Pirris Stephen M. 
Published: August 2016

AbstractBackgroundThe primary aim of this study was to determine the safety and feasibility of capturing and streaming neuronavigation images onto a head‐up display during spine instrumentation.MethodsUsing a novel device, neuronavigation images were captured and transferred wirelessly via a password‐encrypted network to the head‐up display. At the end of the procedure, the surgeons completed a survey to gather their opinions of the system.ResultsForty pedicle screws were placed using the head‐up display. The average screw placement time was slightly shorter when the head‐up display was used (4.13 min with vs. 4.86 min without). The post‐procedure survey demonstrated that 79% of surgeon's responses were positive.ConclusionA wearable head‐up display can benefit current neuronavigation systems, but larger, outcomes‐based trials are needed. Higher processing speed would allow streaming of higher resolution images. Along with an enlarged display, these may significantly improve utilization of this technology. Copyright © 2016 John Wiley & Sons, Ltd.
Polycomb Repressive Complex 2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or Neoplasia
Authors: Oittinen Mikko , Popp Alina , Kurppa Kalle , Lindfors Katri , Mäki Markku , Kaikkonen Minna U. , Viiri Keijo 
Published: August 2016

Abstract
Canonical Wnt/β-catenin signaling regulates the homeostasis of intestinal epithelium by controlling the balance between intestinal stem cell self-renewal and differentiation but epigenetic mechanisms enacting the process are not known. We hypothesized that epigenetic regulator, Polycomb Repressive Complex-2 (PRC2), is involved in Wnt-mediated epithelial homeostasis on the crypt-villus axis and aberrancies therein are implicated both in celiac disease and in intestinal malignancies. We found that PRC2 establishes repressive crypt and villus specific trimethylation of histone H3 lysine 27 (H3K27me3) signature on genes responsible for, for example, nutrient transport and cell killing in crypts and, for example, proliferation and differentiation in mature villi, suggesting that PRC2 facilitates the Wnt-governed intestinal homeostasis. When celiac patients are on gluten-containing diet PRC2 is out-of-bounds active and consequently its target genes were found affected in intestinal epithelium. Significant set of effective intestinal PRC2 targets are also differentially expressed in colorectal adenoma and carcinomas. Our results suggest that PRC2 gives rise and maintains polar crypt and villus specific H3K27me3 signatures. As H3K27me3 is a mark enriched in developmentally important genes, identified intestinal PRC2 targets are possibly imperative drivers for enterocyte differentiation and intestinal stem cell maintenance downstream to Wnt-signaling. Our work also elucidates the mechanism sustaining the crypt hyperplasia in celiac disease and suggest that PRC2-dependent fostering of epithelial stemness is a common attribute in intestinal diseases in which epithelial hyperplasia or neoplasia prevails. Finally, this work demonstrates that in intestine PRC2 represses genes having both pro-stemness and pro-differentiation functions, fact need to be considered when designing epigenetic therapies including PRC2 as a drug target.
Yes-Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage
Authors: Wang Lunchang , Qiu Ping , Jiao Jiao , Hirai Hiroyuki , Xiong Wei , Zhang Jifeng , Zhu Tianqing , Ma Peter X. , Chen Y. Eugene , Yang Bo 
Published: August 2016

Abstract
Vascular smooth muscle cells (VSMCs) derived from cardiovascular progenitor cell (CVPC) lineage populate the tunica media of the aortic root. Understanding differentiation of VSMCs from CVPC will further our understanding of the molecular mechanisms contributing to aortic root aneurysms, and thus, facilitate the development of novel therapeutic agents to prevent this devastating complication. It is established that the yes-associated protein (YAP) and Hippo pathway is important for VSMC proliferation and phenotype switch. To determine the role of YAP in differentiation of VSMCs from CVPCs, we utilized the in vitro monolayer lineage specific differentiation method by differentiating human embryonic stem cells into CVPCs, and then, into VSMCs. We found that expression of YAP decreased during differentiation of VSMC from CVPCs. Overexpression of YAP attenuated expression of VSMC contractile markers and impaired VSMC function. Knockdown of YAP increased expression of contractile proteins during CVPC-VSMCs differentiation. Importantly, expression of YAP decreased transcription of myocardin during this process. Overexpression of YAP in PAC1 SMC cell line inhibited luciferase activity of myocardin proximal promoter in a dose dependent and NKX2.5 dependent manners. YAP protein interacted with NKX2.5 protein and inhibited binding of NKX2.5 to the 5′-proximal promoter region of myocardin in CVPC-derived VSMCs. In conclusion, YAP negatively regulates differentiation of VSMCs from CVPCs by decreasing transcription of myocardin in a NKX2.5-dependent manner.
Irx4 Marks a Multipotent, Ventricular-Specific Progenitor Cell
Authors: Nelson Daryl O. , Lalit Pratik A. , Biermann Mitch , Markandeya Yogananda S. , Capes Deborah L. , Addesso Luke , Patel Gina , Han Tianxiao , John Manorama C. , Powers Patricia A. , Downs Karen M. , Kamp Timothy J. , Lyons Gary E. 
Published: August 2016

Abstract
While much progress has been made in the resolution of the cellular hierarchy underlying cardiogenesis, our understanding of chamber-specific myocardium differentiation remains incomplete. To better understand ventricular myocardium differentiation, we targeted the ventricle-specific gene, Irx4, in mouse embryonic stem cells to generate a reporter cell line. Using an antibiotic-selection approach, we purified Irx4+ cells in vitro from differentiating embryoid bodies. The isolated Irx4+ cells proved to be highly proliferative and presented Cxcr4, Pdgfr-alpha, Flk1, and Flt1 on the cell surface. Single Irx4+ ventricular progenitor cells (VPCs) exhibited cardiovascular potency, generating endothelial cells, smooth muscle cells, and ventricular myocytes in vitro. The ventricular specificity of the Irx4+ population was further demonstrated in vivo as VPCs injected into the cardiac crescent subsequently produced Mlc2v+ myocytes that exclusively contributed to the nascent ventricle at E9.5. These findings support the existence of a newly identified ventricular myocardial progenitor. This is the first report of a multipotent cardiac progenitor that contributes progeny specific to the ventricular myocardium. Stem Cells 2016;34:2875–2888
Accuracy of preoperative tumor localization in large bowel using 3D magnetic endoscopic imaging: randomized clinical trial
Authors: Szura Miroslaw , Pasternak Artur , Solecki Rafal , Matyja Maciej , Szczepanik Antoni , Matyja Andrzej 
Published: August 2016

Abstract
Background
Laparoscopic surgery has become the standard treatment for colorectal cancer. A tumor that does not involve serosa is invisible intraoperatively, and manual palpation of the tumor during laparoscopy is not possible. Therefore, accurate localization of the neoplastic infiltrate remains one of the most important tasks prior to elective laparoscopic surgery. The aim of this study was to evaluate the utility of a magnetic endoscopic imaging (MEI) for precise preoperative endoscopic localization of neoplastic infiltrate within the large bowel.

Materials and methods
The study enrolled 246 patients who underwent elective surgery for colorectal cancer in 2012–2015 with accurate preoperative colonoscopic localization of the tumor. The analysis concerned patients with neoplastic infiltrate localized more than 30 cm from the anal verge. For evaluative purposes and accuracy of localization, the intestine was divided anatomically into 13 parts. Colonoscopic examinations were conducted with two types of endoscopes: group I—with MEI and group II—without MEI. Patients were assigned to the groups by random allocation. Ultimate confirmation of the tumor localization was accomplished by intraoperative evaluation.

Results
Group I involved 127 patients and group II 129. The two groups were compared in terms of age, sex, BMI and frequency of previous abdominal procedures. Proper localization of the lesion was confirmed in 95.23 % of group I patients and in 83.19 % of group II patients (p < 0.05). The greatest discrepancy in localization occurred in 8.9 % of patients from group I and 20 % of patients from group II in which the lesion was assessed primarily in the distal sigmoid.

Conclusions
A magnetic endoscopic imaging allows more accurate localization of neoplastic infiltrate within the large intestine compared to standard colonoscopy alone, especially within the sigmoid colon. This method can be particularly useful in planning and performing laparoscopic procedures to diminish the likelihood of improper bowel segment resection.

ClinicalTrials.gov number
NCT01688557