bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daytime sleepiness and BMI exhibit gender and age differences in patients with central disorders of hypersomnolence
Authors: Ferrazzini Laura , Schmidt Markus , Zhang Zhongxing , Khatami Ramin , Dauvilliers Yves , Barateau Lucie , Mayer Geert , Pizza Fabio , Plazzi Giuseppe , Gool Jari K. , Fronczek Rolf , Lammers Gert Jan , del Rio‐Villegas Rafael , Peraita‐Adrados Rosa , Partinen Markku , Overeem Sebastiaan , Sonka Karel , Santamaria Joan , Heinzer Raphael , Canellas Francesca , da Silva Antonio Martins , Högl Birgit , Veauthier Christian , Wierzbicka Aleksandra , Feketeova Eva , Buskova Jitka , Lecendreux Michel , Miano Silvia , Kallweit Ulf , Heidbreder Anna , Bassetti Claudio L. A. , van der Meer Julia 
Published: October 2024

SummaryThe aim of the present study was to examine gender and age‐specific effects on subjective daytime sleepiness (as measured by the Epworth Sleepiness Scale), body weight and eating behaviour in patients with central disorders of hypersomnolence. Based on the European Narcolepsy Network database, we compared 1035 patients with narcolepsy type I and 505 patients with other central disorders of hypersomnolence (“narcoleptic borderland”), including narcolepsy type II (N = 308) and idiopathic hypersomnia (N = 174), using logistic regression and general linear models. In the entire study population, the Epworth Sleepiness Scale was higher in women (N = 735, mean age = 30 years, mean Epworth Sleepiness Scale = 16.6 ± SD 3.9) than in men (N = 805, mean age = 32 years, mean Epworth Sleepiness Scale = 15.8 ± SD 4.4). In women with narcolepsy type I (N = 475), both Epworth Sleepiness Scale and body mass index increased in parallel with age. In women of the narcoleptic borderland (N = 260), the Epworth Sleepiness Scale markedly peaked in their early 30s, while body mass index only started to rise at that age. This rise in body mass index following the Epworth Sleepiness Scale peak cannot be explained by sleepiness‐induced uncontrolled eating, as self‐reported uncontrolled eating was negatively associated with the Epworth Sleepiness Scale in this group. We propose that the narcoleptic borderland harbours a unique cluster of women in their fertile years with an unexplored aetiology requiring further investigation towards tailored interventions.
How many drugs are repositioned each year in Europe?
Authors: Liddicoat Johnathon , Hamidzadeh Ashleigh , Liddell Kathleen , Aboy Mateo 
Published: October 2024

AbstractFor two decades, commentators have argued for law and policy reform to incentivise organisations to develop new indications for (already) authorised drugs, an area of drug development known as ‘repositioning’. In short, they argue that hurdles in patent and pharmaceutical law hinder repositioning and, therefore, reform is required to increase its use. Yet, these arguments are made primarily on anecdotes; the empirical evidence is scant. One foundational question is how many drugs are repositioned each year in Europe. This study develops a method to examine the number authorised each year. The results show a marked increase in repositioning over the last 3 years, and that the number per year is comparable, though slightly fewer than, the number of new compounds, indicating modest to higher‐than‐expected activity. This study considers what the results mean for four suggested reform options, including the EU Commission's recent proposal. We conclude that the reforms may not achieve their goals or that further evidence is required before we can know whether they will be effective. Lastly, this paper explains how the method and data in this study could serve as a benchmark for evaluating the success of future reforms.
Long‐term outcome of tacrolimus‐based immunosuppressive treatment for patients with paediatric‐onset lupus nephritis
Authors: Tanaka Hiroshi , Aizawa Tomomi , Endo Morito 
Published: October 2024

AbstractAimWe have previously reported the mid‐term efficacy and safety of tacrolimus (Tac)‐based immunosuppressive therapy in such patients, and herein, we aimed to determine their long‐term outcomes (over 10 years).MethodsWe retrospectively evaluate the data of 13 consecutive patients with biopsy‐proven long‐standing LN who underwent a long‐term Tac‐based treatment regimen. Tac was administered once daily at a dose of 3 mg as reinduction or maintenance treatment. Treatment outcomes were defined using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), urinary protein/creatinine ratio (Up/cr), serum creatinine, estimated glomerular filtration rate (eGFR) and serological lupus markers (complement C3, complement hemolytic activity [CH 50], and anti‐dsDNA antibody titre), and the concomitantly administered prednisolone (PDN) dose. Data on clinical parameters and serological lupus activity were collected annually from each patient throughout the study period.ResultsThe patients' baseline characteristics at the treatment initiation were as follows: mean age, 18 years; Up/cr, 0.63 ± 0.69; serum C3 level, 57.2 ± 22.4 mg/dL (normal range, 79–152 mg/dL); CH50, 27.9 ± 15.7 U/mL (normal range, 23.0–46.0 U/mL); serum anti‐dsDNA antibody titre, 111.7 ± 123.4 IU/mL (normal range, <12.0 IU/mL); serum creatinine, 0.60 ± 0.19 mg/dL; eGFR, 115.6 ± 21.3 mL/min and SLEDAI, 13 ± 8.1. Despite the gradual tapering of the concomitantly administered PDN dose from 18.7 ± 13.5 mg/day at baseline to 3.5 ± 2.8 mg/day at 10 years (p = .002), a marked improvement in the outcomes, compared with the baseline values, was observed within a year. Additionally, these favourable changes persisted throughout study period in most patients. Compared with the baseline values, the following measures confirmed sustained outcome improvements after a 10‐year treatment: SLEDAI, 1.7 ± 2.0; serum C3 level, 83.8 ± 16.1 mg/dL; CH50, 45.6 ± 10.9 U/mL (all p < .01) and Up/cr, 0.16 ± 0.18 and serum anti‐dsDNA antibody titre, 25.8 ± 28.8 IU/mL (both p < .05). Serum creatinine level and eGFR remained within the normal range in all study participants except for one patient who experienced several flare‐ups. No serious adverse effects were observed.ConclusionOur results suggest that long‐term Tac‐based immunosuppressive treatment as maintenance therapy is beneficial and has low cytotoxicity. Therefore, it represents an attractive option for the treatment of selected patients with paediatric‐onset LN in a real‐world setting.image
Disorders of puberty and neurodevelopment: A shared etiology?
Authors: Read Jordan E. , Vasile‐Tudorache Alexandru , Newsome Angel , Lorente María José , Agustín‐Pavón Carmen , Howard Sasha R. 
Published: October 2024

AbstractThe neuroendocrine control of puberty and reproduction is fascinatingly complex, with up‐ and down‐regulation of key reproductive hormones during fetal, infantile, and later childhood periods that determine the correct function of the hypothalamic–pituitary–gonadal axis and the timing of puberty. Neuronal development is a vital element of these processes, and multiple conditions of disordered puberty and reproduction have their etiology in abnormal neuronal migration or function. Although there are numerous documented cases across multiple conditions wherein patients have both neurodevelopmental disorders and pubertal abnormalities, this has mostly been described ad hoc and the associations are not clearly documented. In this review, we aim to describe the overlap between these two groups of conditions and to increase awareness to ensure that puberty and reproductive function are carefully monitored in patients with neurodevelopmental conditions, and vice versa. Moreover, this commonality can be explored for clues about the disease mechanisms in these patient groups and provide new avenues for therapeutic interventions for affected individuals.
Randomized Controlled Trial Comparing Training of Transseptal Puncture With or Without Intracardiac Echocardiography
Authors: Guo Qi , Sang Caihua , Lai Yiwei , Gao Mingyang , Guo Xueyuan , Dai Wenli , Li Songnan , Liu Nian , Zuo Song , Long Deyong , Dong Jianzeng , Ma Changsheng 
Published: October 2024

ABSTRACTBackgroundIntracardiac echocardiography (ICE) has been widely used in the catheter ablation of atrial fibrillation (AF). However, the value of ICE in the training of transseptal puncture (TSP) is unclear.MethodsICE‐Training Study was a single‐center, parallel‐group, unmasked, randomized controlled trial registered in ChineseClinicalTrials.gov. Participants were randomly assigned (1:1) to different groups (1) the ICE simulator training group (ICE‐ST), in which TSP was trained and performed under the guidance of both ICE and x‐ray; and (2) the conventional simulator training group (Con‐ST), in which TSP was trained and performed only under the guidance of x‐ray. The trainees need to undergo the training stage and the evaluation stage.ResultsFrom October 2022 to December 2022, 18 consecutive fellows (age 32.4 ± 4.4 years, 12 males) without experience of TSP were included. The training period (16.9 ± 6.6 vs. 29.6 ± 8.7 times, p = 0.003) and the fluoroscopy time (120.3 ± 25.3 vs. 189.3 ± 40.2 s, p < 0.001) of the ICE‐ST group was significantly shorter than that of the Con‐ST group. No significant difference was found in the comprehensive performance of TSP in the ICE‐ST group (composite score 96.7 ± 5.7) and the Con‐ST group (composite score 95.9 ± 6.3, p = 0.62), but the selection of TSP sites in the ICE‐ST group was commonly better than that in the Con‐ST group.ConclusionsICE could improve the efficiency of TSP training and optimize the site of TSP to facilitate catheter manipulation in the ablation.Trial RegistrationChineseClinicalTrials.gov identifier: ChiCTR2200058377
Catheter Ablation of Tachycardia Involving Twin/Single Atrioventricular Node in Patients With Right Isomerism
Authors: Terashi Eiko , Suzuki Tsugutoshi , Yoshida Yoko , Fukudome Keisuke , Nakamura Yoshihide 
Published: October 2024

ABSTRACTAimsIn addition to well‐documented tachycardias involving twin atrioventricular (AV) nodes, tachycardias involving a single node have been clinically experienced in right atrial isomerism (RAI). This study aimed to characterize the AV node involvement patterns and evaluate the outcome of ablation therapy in RAI patients with tachycardias.MethodsWe retrospectively analyzed the medical records of 16 RAI patients who underwent catheter ablation of tachycardias involving twin or single AV nodes at our center between April 2006 and March 2020.ResultsA total of 22 ablation procedures were performed in 16 patients. The median age and body weight were 2 years (range 20 months–31 years) and 11.2 kg (range 7.4–42 kg), respectively. Two QRS complexes were confirmed in 11/16 patients, and a single QRS complex in 5/16. The dominant AV node was anterior in 7/16. Four patterns of tachycardias were identified: tachycardias reciprocating between two AV nodes with retrograde conduction through the anterior AV node (3/16) or through the posterior AV node (4/16); and reentrant tachycardias involving the anterior AV node only (3/16) or posterior AV node only (6/16). Ablation successfully eliminated the tachycardias in 15/16 patients (93.8%). Recurrence was reported in 7/16 (44%) during a median follow‐up period of 96.5 months. Five of those 7 patients underwent additional ablation, and the tachycardias were eliminated in 3/5 patients. None of the patients developed ventricular asynchrony after ablation.ConclusionTranscatheter ablation was effective in RAI patients with tachycardias involving twin or single AV nodes, and deterioration of the cardiac function was rare.
Precision Phenotyping in Crop Science: From Plant Traits to Gene Discovery for Climate‐Smart Agriculture
Authors: Visakh Ravindran Lalithambika , Anand Sreekumar , Reddy Sathanur Bhaskar , Jha Uday Chand , Sah Rameswar Prasad , Beena Radha 
Published: October 2024

ABSTRACTThe global population is placing unprecedented demand on food systems, which can be met only through a complex interplay of technology, sustainable food production intensification methods and climate resilience. To address such compounded requirements, developing high‐yielding crop varieties using precise plant breeding methods bolstered with efficient and nondestructive plant trait documentation approaches is vital. High‐throughput crop phenotyping (HTCP) platforms have prominently emerged as a mainstream approach for reducing the phenotyping bottleneck in breeding programmes. HTCP has the potential to provide detailed quantitative information of large plant populations under different growth stages across diverse environmental regimes, facilitating accelerated plant breeding strategies. New imaging platforms also enable nondestructive characterization of a wide range of above and below‐ground crop parameters. The specificity in use of sensors, automation of data collection, large‐scale data handling systems and accurate analytical tools have a substantial role in dynamic crop monitoring and big data interpretation. HTCP platforms are capable of making precise measurements of a wide range of physiological, morphological, biochemical and stress responses in plants. Developments of sensors with improved precision, intervention of unmanned aerial vehicles, robotics, computed tomography and machine learning have given a dramatic developmental leap to precise and large‐scale crop phenotyping. This review provides an avenue for understanding various high‐throughput phenotyping platforms, working principles, current developments and contributions to high‐throughput phenotyping of various crops under laboratory and field conditions. A detailed comparative idea on the advantages and pitfalls of these available platforms can help researchers in choosing the right technology suiting specific practical requirements. Furthermore, the review aims to provide novel future prospects and developmental requirements that can potentially widen the application and utilization of these HTCP technologies in agriculture.
“Weak characters” easily shaped, or strong‐minded conscientious objectors impervious to change?
Authors: Perkins Gary 
Published: October 2024

AbstractCommentaries on the World War I history of the International Bible Students Association in their USA homeland usually feature decisions made by the movement's leadership and their subsequent arrest and prosecution, supposedly for conspiring to violate the Espionage Act and attempting to cause refusal of duty in the armed forces of the United States. In so doing, these neglect to consider the enthusiastic support and voices of their adherents. In contrast, and in response to Zoe Knox's April 2019 Peace & Change article, this study unmutes the voices of their conscientious objectors and proposes that their experiences were profoundly significant in shaping the movement over the following century.
Virulence characterization of wheat stripe rust population in China in 2023
Authors: Zhang Xingzong , Huang Liang , Tang Wanqiang , Qiu Age , Li Xin , Zhou Xinli , Yang Suizhuang , Wang Meinan , Chen Xianming , Chen Wanquan , Liu Tai‐guo , Xia Chongjing 
Published: October 2024

AbstractWheat stripe rust, caused by Puccinia striiformis f. sp. tritici (Pst), significantly impacts global wheat production, including China. Monitoring Pst virulence is crucial for disease management. This study used 18 Yr single‐gene isogenic lines of wheat to characterize the virulence of 2023 Pst collections in China. A total of 103 isolates were collected from 11 provinces, and 61 races were identified. Frequencies of virulence to the 18 Yr genes varied from 0% to 95.1%, with low frequencies (defined as less than 10%) to Yr85 (7.8%) and Yr10 (8.7%); moderate frequencies (10%–40%) to Yr24 (15.5%), Yr32 (16.5%), YrSP (37.9%) and Yr76 (37.9%); and high frequencies (>40%) to Yr7 (47.6%), Yr1 (68.0%), Yr9 (69.9%), Yr27 (69.9%), Yr17 (79.6%), Yr6 (89.3%), YrExp2 (92.2%), Yr43 (93.2%), Yr8 (95.1%) and Yr44 (95.1%). Yr6, Yr8, Yr17, Yr27, Yr43, Yr44 and YrExp2 have almost lost their effectiveness in all provinces, while Yr10, Yr24, Yr32 and Yr85 are effective in Hebei, Shandong, Shaanxi, Gansu and Anhui. No isolate was virulent to Yr5 or Yr15, indicating their effectiveness against Pst populations in China. The Pst isolates had a wide virulence spectrum ranging from 3 to 16 virulence factors, with an average of 9.5. Comparing 2023 to 2021, the PstCN‐040 and races sharing virulence to Yr1, Yr6, Yr7, Yr8, Yr9, Yr17, Yr43, Yr44 and YrExp2 predominated, with frequencies 16.4% and 25.2%. This study provides valuable information on the virulence composition of Pst populations in China, helping to guide the development of genetic resistance for wheat in China.
Singular loci of algebras over ramified discrete valuation rings
Authors: KC Nawaj 
Published: October 2024

AbstractWhen is a field, the classical Jacobian criterion computes the singular locus of an equidimensional, finitely generated ‐algebra as the closed subset of an ideal generated by appropriate minors of the so‐called Jacobian matrix. Recently, Hochster‐Jeffries and Saito have extended this result for algebras over any unramified discrete valuation ring of mixed characteristic via the use of ‐derivations. Motivated by these results, in this paper, we state and prove an analogous Jacobian criterion for algebras over ramified discrete valuation rings of mixed characteristic.
The Lubin–Tate theory of configuration spaces: I
Authors: Brantner D. Lukas B. , Hahn Jeremy , Knudsen Ben 
Published: October 2024

AbstractWe construct a spectral sequence converging to the Lubin–Tate theory, that is, Morava ‐theory, of unordered configuration spaces and identify its ‐page as the homology of a Chevalley–Eilenberg‐like complex for Hecke Lie algebras. Based on this, we compute the ‐theory of the weight summands of iterated loop spaces of spheres (parametrising the weight operations on ‐algebras), as well as the ‐theory of the configuration spaces of points on a punctured surface. We read off the corresponding Morava ‐theory groups, which appear in a conjecture by Ravenel. Finally, we compute the ‐homology of the space of unordered configurations of particles on a punctured surface.
Supporting professional practice transition in undergraduate nursing education: a scoping review protocol
Authors: Orr Elizabeth , Kuipers Meredith , Yates Elizabeth , Halverson Kathryn 
Published: October 2024

Objective:
This scoping review will describe educational programming that supports undergraduate student nurses’ transition-to-practice and/or enhances practice readiness.

Introduction:
The period of transition from nursing student to professional nurse is fraught with challenges stemming from the evolving role and the increasing demands of independent practice. While transition-to-practice programming exists for the new graduate nurse, there is less focus on preparing the student in their final year of education. A scoping review will identify educational programming delivered to nursing students approaching graduation that facilitate transition-to-practice success and/or improve practice readiness.

Inclusion criteria:
This review will consider literature describing educational programming that supports transition-to-practice success and/or practice readiness and that demonstrates evidence of evaluation. Studies that involve primarily pre-licensure, undergraduate, or baccalaureate nursing students will be included. Reports of primary studies, reviews, dissertations and theses, conference proceedings, and nursing trade publications that describe quantitative, qualitative, or mixed methods will be included.

Methods:
The proposed review will adhere to the JBI methodology for scoping reviews. A comprehensive search will be conducted in CINAHL (EBSCOhost), MEDLINE (Ovid), Healthstar (Ovid), and Nursing and Allied Health (ProQuest) using a search strategy developed in consultation with an expert university librarian. Two independent reviewers will screen articles by title and abstract and assess the full text of each selected citation against inclusion criteria. Quantitative methods (descriptive statistics) and basic qualitative content analysis will be used to analyze the data, and results will be reported in narrative and graphic formats.

Review registration:
Open Science Framework osf.io/2vsbq
Stability of Thermal Convection in Two Superimposed Miscible Viscous Fluids Under Gravitational Modulation
Authors: Echchadli Mourad , Aniss Saïd 
Published: October 2024

Abstract
The thermal stability of a system of two superimposed miscible viscous fluid layers, under gravitational modulation, is investigated using linear stability analysis. It is well known in the literature that in the absence of gravitational modulation, there exist two convection regimes depending on the buoyancy number: the single-cell regime, where convection is oscillating and occupies the entire volume of the two fluid layers, and the stratified regime where stationary convection occurs in each fluid layer. Using Chebyshev's spectral collocation method and Floquet's theory, the numerical results show that under gravitational modulation, single-cell convection oscillates at half the frequency of the external oscillation (subharmonic threshold), while the stratified regime oscillates at a frequency equal to that of the forcing (harmonic threshold). The critical buoyancy number corresponding to the transition between the two convection regimes depends, in addition to the viscosity ratio and the depth of the two layers, on certain dimensionless frequencies permeating this transition and also on the amplitude of oscillation via the Froude number. In the plane of the critical Rayleigh number versus dimensionless modulation frequency, the branch associated with stratified convection does not depend on the buoyancy number for equal viscosities whereas this is the case for the whole-convection regime. For different viscosities, both convection regimes depend on the buoyancy number. At last, in the stratified regime (harmonic threshold), the critical value of the viscosity contrast, corresponding to the passage from an active layer to a passive layer and vice versa, increases with the modulation frequency.
An Actuator-Disk Model Augmentation for Low-Pressure Axial Fan Simulation
Authors: Venter Adam J. , Owen Michael T. F. , Muiyser Jacques 
Published: October 2024

Abstract
Actuator-disk rotor models are important simulation tools for cost-effective industrial axial fan system analysis. Actuator-disk fan model performance, however, is constrained by the conventional use of two-dimensional airfoil coefficient input data, which limits the accuracy of the models to a narrow operating range free from significant radial blade flow. Radial blade flow is characteristic of off-design fan operation, which is often unavoidable within typical industrial fan system environments, so the enhancement of actuator-disk model performance for these conditions is desired. This paper accordingly presents a new means of robustly determining actuator-disk model coefficient inputs that are suitable for a wide range of fan operating conditions. The proposed augmented actuator-disk method (AADM) capitalizes on new insights into the unique aerodynamic behavior of low-pressure axial fan rotors. The performance of the AADM is evaluated for two different industrial cooling fans and is shown to outperform existing actuator-disk coefficient formulations through computational fluid dynamics simulations. The AADM is shown to better predict key fan performance metrics, spanwise blade force distributions, and to produce flow fields that are more physically representative (an important feature for industrial heat exchanger studies where the AADM is anticipated to be commonly applied). The AADM has been developed to be easily adopted in generic industrial fan analyses and is expected to serve as a valuable springboard for future actuator-disk fan model developments.