bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Juvenile Psoriatic Arthritis Cohort in the CARRA Registry: Clinical Characteristics, Classification, and Outcomes
Authors: Zisman Devy , Gladman Dafna D. , Stoll Matthew L. , Strand Vibeke , Lavi Idit , Hsu Joyce J. , Mellins Elizabeth D. ,   The CARRA Legacy Registry Investigators
Published: February 2017

Objective.Children with clinically diagnosed juvenile psoriatic arthritis (JPsA) who were enrolled in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) registry (CARRA-JPsA) were classified according to pediatric International League of Associations for Rheumatology (ILAR) and adult criteria [Classification criteria for Psoriatic Arthritis (CASPAR)]. Data on demographic and clinical features at baseline and 1-year followup were analyzed and compared.Methods.Cross-sectional analysis was performed of CARRA-JPsA patients enrolled between May 2010 and December 2013 and stratified according to age at disease onset (≤ or > 4 yrs). Features of patients fulfilling ILAR and CASPAR criteria were compared at baseline and followup using chi square, Fisher’s exact, Mann-Whitney-McNemar, Wilcoxon signed rank, and t tests, as appropriate.Results.Among 361 children enrolled as CARRA-JPsA, 72.02% had symptom onset at > 4 years of age, with a male predominance and high prevalence of enthesitis. At followup, statistically significant improvements were reported in arthritis, dactylitis, enthesitis, psoriasis, sacroiliitis, and nail pitting, but not in health questionnaire (HQ) scores. Of the patients, 80.5% fulfilled ILAR criteria for JPsA. Fifty-two patients, whose disease fulfilled CASPAR criteria but had not been included in the JPsA cohort, manifested more enthesitis, sacroiliitis, inflammatory bowel disease and uveitis and less psoriasis.Conclusion.The data support division of patients with JPsA into 2 clinical subgroups, according to age at disease onset. Improvement in objective findings did not correlate with changes in HQ scores. Pediatric rheumatologists currently do not diagnose JPsA in all children whose disease manifestations meet CASPAR criteria. Unification of adult and pediatric PsA classification criteria warrants consideration.
Antenatal Suppression of IL-1 Protects against Inflammation-Induced Fetal Injury and Improves Neonatal and Developmental Outcomes in Mice
Authors: Nadeau-Vallée Mathieu , Chin Peck-Yin , Belarbi Lydia , Brien Marie-Ève , Pundir Sheetal , Berryer Martin H. , Beaudry-Richard Alexandra , Madaan Ankush , Sharkey David J. , Lupien-Meilleur Alexis , Hou Xin , Quiniou Christiane , Beaulac Alexandre , Boufaied Ines , Boudreault Amarilys , Carbonaro Adriana , Doan Ngoc-Duc , Joyal Jean-Sebastien , Lubell William D. , Olson David M. , Robertson Sarah A. , Girard Sylvie , Chemtob Sylvain 
Published: February 2017

Abstract
Preterm birth (PTB) is commonly accompanied by in utero fetal inflammation, and existing tocolytic drugs do not target fetal inflammatory injury. Of the candidate proinflammatory mediators, IL-1 appears central and is sufficient to trigger fetal loss. Therefore, we elucidated the effects of antenatal IL-1 exposure on postnatal development and investigated two IL-1 receptor antagonists, the competitive inhibitor anakinra (Kineret) and a potent noncompetitive inhibitor 101.10, for efficacy in blocking IL-1 actions. Antenatal exposure to IL-1β induced Tnfa, Il6, Ccl2, Pghs2, and Mpges1 expression in placenta and fetal membranes, and it elevated amniotic fluid IL-1β, IL-6, IL-8, and PGF2α, resulting in PTB and marked neonatal mortality. Surviving neonates had increased Il1b, Il6, Il8, Il10, Pghs2, Tnfa, and Crp expression in WBCs, elevated plasma levels of IL-1β, IL-6, and IL-8, increased IL-1β, IL-6, and IL-8 in fetal lung, intestine, and brain, and morphological abnormalities: e.g., disrupted lung alveolarization, atrophy of intestinal villus and colon-resident lymphoid follicle, and degeneration and atrophy of brain microvasculature with visual evoked potential anomalies. Late gestation treatment with 101.10 abolished these adverse outcomes, whereas Kineret exerted only modest effects and no benefit for gestation length, neonatal mortality, or placental inflammation. In a LPS-induced model of infection-associated PTB, 101.10 prevented PTB, neonatal mortality, and fetal brain inflammation. There was no substantive deviation in postnatal growth trajectory or adult body morphometry after antenatal 101.10 treatment. The results implicate IL-1 as an important driver of neonatal morbidity in PTB and identify 101.10 as a safe and effective candidate therapeutic.
Utilidad de los modelos de viscoelasticidad en el aprendizaje de la ingeniería de materiales poliméricos
Authors: Fombuena V. , Boronat T. , Sánchez-Nácher L. , García-Sanoguera D. , Balart R. 
Published: February 2017

<p>El presente artículo realiza una breve descripción sobre los modelos matemáticos de viscoelasticidad más simples: Modelo de Maxwell y Modelo de Kelvin-Voigt. No obstante, estos modelos básicos poseen una serie de limitaciones ya que se desvían de forma considerable de la realidad. Así pues, un modelo más apropiado en el estudio de la viscoelasticidad en polímeros es el modelo de Burgers. Mediante la resolución de un caso práctico se pone de manifiesto la utilidad de los modelos matemáticos en la comprensión y predicción por parte del alumnado del comportamiento mecánico de un polímero en un proceso como la fluencia y/o relajación donde interviene la variable tiempo.</p>
Hacer ciencia para comunicar ciencia desde 1º de ESO: aprender a pensar, leer, realizar, hablar y escribir ciencia
Authors: Menoyo Díaz María del Pilar 
Published: February 2017

<p>En este artículo, presentamos el proyecto “Fer cièencia per comunicar cièencia des de 1r d'ESO: Aprendre a pensar, llegir, fer, parlar i escriure ciència", ganador del segundo premio</p><p>Etica y Ciència para centros de enseñanza 2015, promovido por la fundación Víctor Grifols i Lucas. Con el proyecto pretendemos que el alumnado adquiera a lo largo de la ESO, de una manera gradual y desde todas las áreas, una alfabetización científica de calidad y por lo tanto que adquiera competencias científicas y lingüísticas que le capaciten para plantearse preguntas cuya respuesta necesite una investigación. También pretendemos fomentar en el alumnado el tratamiento ético de las fuentes de consulta, así como de la obtención de datos y del uso sostenible de los recursos que tienen a su alcance. Pretendemos fomentar la comunicación y divulgación externa del proceso y resultado de las investigaciones, a través del punto de encuentro de enseñanza-aprendizaje que representa la web del instituto Juan Manuel Zafra, sin acceso a visitantes de los diferentes cursos Moodle, o con acceso a visitantes a través de la revista, las diferentes noticias, los tweets o los blogs. Y participando en encuentros de jóvenes investigadores, como Exporecerca Jove, Jóvenes Investigadores, Galiciencia o Jornadas de ciencias En este artículo mostramos una propuesta de graduación de la aplicación de las competencias científicas y lingüísticas a lo largo de la ESO y marcos donde iniciar al alumnado en la realización de trabajos de investigación.</p>
Proyecto Quick Natura. Técnologías móviles aplicadas a rutas botánicas urbanas
Authors: Ripoll Sergio , Mayoral Olga , Azkárraga Jose Maria 
Published: February 2017

<p>El proyecto Quick Natura pretende acercar a las personas que habitan o visitan espacios urbanos de la ciudad de Valencia al entorno vegetal que les rodea, de una manera rápida y amena. La iniciativa se basa en el uso de las nuevas tecnologías para conectar el mundo físico con el virtual mediante la colocación de códigos QR (<em>Quick Response code</em>, “código de respuesta rápida”) en diferentes especies vegetales de jardines, parques y espacios urbanos y periurbanos. Cualquier usuario podrá escanear con un Smartphone u otro dispositivo móvil el código QR ubicado en las plantas etiquetadas, permitiendo el acceso inmediato a una capa de información amena y de fácil comprensión sobre ese ejemplar. El método permite asociar los códigos QR a la página web www.uv.es/quicknatura en el cual cada planta está alojada en un espacio virtual donde los usuarios podrán ver: información sobre la especie a través de preguntas y curiosidades, su ubicación actual, la ubicación de otros códigos QR cercanos y una serie de rutas diseñadas para diferentes jardines de la ciudad de Valencia. El proyecto permite un uso tanto particular como tutelado, con un guía acompañante que pueda complementar la información obtenida a través de Quick Natura. </p>
Lasers in Apicoectomy: A Brief Review
Authors: Mohammadi Zahed , Shalavi Sousan , Kinoshita Jun-Ichiro , Jafarzadeh Hamid , Giardino Luciano 
Published: February 2017

ABSTRACTSince the invention of laser, various applications for lasers in endodontics have been proposed, such as disinfection of the root canal system, canal shaping, pulp diagnosis, and apicoectomy. One of the major applications of laser in endodontics is apicoectomy. The aim of this article is to review the benefits and drawbacks of laser applications in apicoectomy, including effect on apical seal, effect on dentin permeability, effect on postsurgery pain, effect on crack formation, effect on root-end morphology, effect on treatment outcome, and connective tissue response to laser-treated dentin.How to cite this articleMohammadi Z, Jafarzadeh H, Shalavi S, Kinoshita J-I, Giardino L. Lasers in Apicoectomy: A Brief Review. J Contemp Dent Pract 2017;18(2):170-173.
An Evaluation of The Effectiveness of Teachers’ Professional Development (TPD) in Iran using Akker Spider Web Model
Authors: Sabzian Fouzieh , Ismail Zurida , Ismail Shaik Abdul Malik Mohamed , Vajargah Kourosh Fathi 
Published: February 2017

Teaching is a complex job, involving classroom management, lesson’s preparation and organization of teaching and learning process, creating and keeping a certain climate, evaluation and feedback. there is consensus on what composes good teaching while teachers have a vital role to any endeavor to grow education. Of course it is very important that not all teachers are effective .The role of the teacher as the exclusive holder of expert knowledge is being worn away by communication technologies. As the social framework of society is changing, the educative role of teachers becomes more complex. Teachers are one of the important foundations of all educational systems. In many countries, extensive programs like maintaining and building good teachers have turned into a fundamental strategy. In fact, teachers' roles and functions are relatively similar in most countries. Usually, teachers are expected to possess all the scientific and technical merits, to dominate course contents and apply appropriate methods and techniques for training, in order to be an appropriate model to educate the youngsters. This paper shows how stakeholders identify the strengths and deficiencies of teachers’ professional development (TPD) with respect to in-service training and according to ten components of Akker Spider Web Model. The aims of this paper are to define evaluation, elaborate educational system in Iran, clarify teacher education, describe effectiveness teachers’ professional development, explain teaching, state the necessity of evaluation, discuss the necessity of teachers’ training and describe of ten components of Akker Model.
Understanding of Women in Indonesia: Motivation to Lead, Work-Family Conflict, and Ambition
Authors: . Sumarto , Permanasari Resi 
Published: February 2017

There is a positive relationship between the high woman representation in public and the success of corruption and poverty eradication. This means that the role of women becomes very strategic along with the increase of woman representation in public region. In Indonesia, the problem is that woman represen­tation is very low in public region, and from time to time it tends to decline. The low woman representation indicates that the motivation of women to lead is lower than men. It is estimated that work-family conflicts and ambition of women are the significant factors which is cause the low motivation of women to lead in Indonesia. The population consists of the civil servants of local governement in “Gerbangkertasusila” East Java. The data were collected by distributing questionares to respondents. Four relationship hypotheses were signifincantly proven. These are : 1) the motivation of women to lead is lower than man; 2) the higher of women’s work family conflict, the weaker the motivation of women to lead ; 3) the stronger motivation of women to lead, the stronger of women’s work family conflicts; 4) the stronger the interaction between women’s ambition and work-family conflict, the weaker the motivation of women to lead.
Assessing the Performance-based Logistics Service Model for Taiwan's Heavy Vehicle Supply Chains
Authors: Ivan Su Shong-Iee , Cui Lianguang , Hertz Susanne 
Published: February 2017

ABSTRACT
This article investigates the performance-based logistics (PBL) theory and explores the potential of introducing the PBL service model to Taiwan's heavy vehicle supply chains. A multiple case study approach is used to explore this research question. Four case firms are selected for this study. The analyses have identified several major risks and influencing factors that hinder the application of the PBL model to Taiwan's heavy vehicle supply chains. However, with PBL's strength to bring sustainability benefits, an extended assessment analysis of the risks and influencing factors is conducted, and the counter-risk strategies are explored. This study has shown there is a high opportunity for PBL development in Taiwan if the obstacles can be dealt collaboratively in the heavy vehicle supply chains. The research findings provide valuable insights into Taiwan's heavy vehicle supply chains and similar emerging Asian economies relying mainly on international heavy vehicle suppliers.
Determination of Diquat Residues in Potato Using Reversed-Phase Liquid Chromatography with Tandem Mass Spectrometry
Authors: Attallah Emad R , Soliman Mostafa , Abo-Aly Mohamed M 
Published: February 2017

Abstract
A simple, modified quick, easy, cheap, effective, rugged, and safe procedure was developed for the determination of diquat in potato using reversed-phase LC coupled with tandem MS(MS/MS) in a total run time of 10 min. Different sample preparation parameters (pH modifier type, sample size, and elevatedtemperature) were tested and optimized. Potato sample was extracted with acetonitrile in the presence of ammonium hydroxide at 80°C. Phase separation was obtained by shaking the extract with magnesium sulfate and sodium chloride, and analysis was done using LC-MS/MS. Matrix-matched standard calculations were used to compensate for matrix-induced suppressionin LC-MS/MS determination. The precision and trueness of the method were determined from recovery experiments on five replicates of spiked blank potato samples at 0.01, 0.05, and 0.1 mg/kg. The range of the obtained recoveries was 74–110%, with RSD values &lt;5% for all the concentrations.
Ionospheric‐thermospheric UV tomography: 2. Comparison with incoherent scatter radar measurements
Authors: Dymond K. F. , Nicholas A. C. , Budzien S. A. , Stephan A. W. , Coker C. , Hei M. A. , Groves K. M. 
Published: February 2017

AbstractThe Special Sensor Ultraviolet Limb Imager (SSULI) instruments are ultraviolet limb scanning sensors that fly on the Defense Meteorological Satellite Program F16‐F19 satellites. The SSULIs cover the 80–170 nm wavelength range which contains emissions at 91 and 136 nm, which are produced by radiative recombination of the ionosphere. We invert the 91.1 nm emission tomographically using a newly developed algorithm that includes optical depth effects due to pure absorption and resonant scattering. We present the details of our approach including how the optimal altitude and along‐track sampling were determined and the newly developed approach we are using for regularizing the SSULI tomographic inversions. Finally, we conclude with validations of the SSULI inversions against Advanced Research Project Agency Long‐range Tracking and Identification Radar (ALTAIR) incoherent scatter radar measurements and demonstrate excellent agreement between the measurements. As part of this study, we include the effects of pure absorption by O2, N2, and O in the inversions and find that best agreement between the ALTAIR and SSULI measurements is obtained when only O2 and O are included, but the agreement degrades when N2 absorption is included. This suggests that the absorption cross section of N2 needs to be reinvestigated near 91.1 nm wavelengths.
Using spectral shape and predictor fluence to evaluate temporal dependence of exposures from solar particle events
Authors: Kim Myung‐Hee Y. , Blattnig Steve R. , Clowdsley Martha C. , Norman Ryan B. 
Published: February 2017

AbstractReal‐time estimation of exposure levels has been considered in NASA's operational strategies and structural capability for the protection of astronauts from exposure to large solar particle events (SPEs). The temporal profile of organ dose rates is also important for the analysis of dose‐rate‐dependent biological responses and the optimization of radiation shielding and future mission planning. A realistic temporal estimation of exposure profiles relies on (1) the complete energy spectrum of SPE that defines the boundary condition for radiation transport simulation, (2) the radiation transport simulation with detailed shielding and body geometry models that determines particle transmission at each critical body organ, and (3) the assessment of organ dosimetric quantities and biological risks by applying the corresponding response models. This paper introduces a process of rapidly estimating temporal exposures to SPEs by implementing the distributions of the organ doses and the spectral‐shape characterization of the major SPEs. Simultaneously, the unconditional probability exceeding the NASA 30 day limit of a blood‐forming organ dose is estimated by taking into account the variability of detailed spectra of SPEs for a given predictor fluence. These temporal evaluations of SPEs can be applied to the development of real‐time guidance and protection system on improving mitigation of adverse effects during space missions.
An exospheric temperature model from CHAMP thermospheric density
Authors: Weng Libin , Lei Jiuhou , Sutton Eric , Dou Xiankang , Fang Hanxian 
Published: February 2017

AbstractIn this study, the effective exospheric temperature, named as T∞, derived from thermospheric densities measured by the CHAMP satellite during 2002–2010 was utilized to develop an exospheric temperature model (ETM) with the aid of the NRLMSISE‐00 model. In the ETM, the temperature variations are characterized as a function of latitude, local time, season, and solar and geomagnetic activities. The ETM is validated by the independent GRACE measurements, and it is found that T∞ and thermospheric densities from the ETM are in better agreement with the GRACE data than those from the NRLMSISE‐00 model. In addition, the ETM captures well the thermospheric equatorial anomaly feature, seasonal variation, and the hemispheric asymmetry in the thermosphere.
Rationally Developed Organic Salts of Tolfenamic Acid and Its β‐Alanine Derivatives for Dual Purposes as an Anti‐Inflammatory Topical Gel and Anticancer Agent
Authors: Parveen Rumana , Sravanthi Bommagani , Dastidar Parthasarathi 
Published: February 2017

AbstractA new series of primary ammonium monocarboxylate (PAM) salts of a nonsteroidal anti‐inflammatory drug (NSAID), namely, tolfenamic acid (TA), and its β‐alanine derivatives were generated. Nearly 67 % of the salts in the series showed gelling abilities with various solvents, including water (biogenic solvent) and methyl salicylate (typically used for topical gel formulations). Gels were characterized by rheology, electron microscopy, and so forth. Structure–property correlations based on single‐crystal and powder XRD data of several gelator and nongelator salts revealed intriguing insights. Studies (in vitro) on an aggressive human breast cancer cell line (MDA‐MB‐231) with the l‐tyrosine methyl ester salt of TA (S7) revealed that the hydrogelator salt was more effective at killing cancer cells than the mother drug TA (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assay); displayed better anti‐inflammatory activity compared with that of TA (prostaglandin E2 assay); could be internalized within the cancer cells, as revealed by fluorescence microscopy; and inhibited effectively migration of the cancer cells. Thus, the easily accessible ambidextrous gelator salt S7 can be used for two purposes: as an anti‐inflammatory topical gel and as an anticancer agent.
Synthesis of Sebacic Acid Using a De Novo Designed Retro‐Aldolase as a Key Catalyst
Authors: Otte Konrad B. , Maurer Elena , Kirtz Marko , Grabs Daniela , Althoff Eric , Bartsch Sebastian , Vogel Andreas , Nestl Bettina M. , Hauer Bernhard 
Published: February 2017

AbstractThe production of new organic compounds from natural feedstocks drives the construction of new biosynthetic cascades. To develop and generate valuable complex chemicals, it is necessary to go beyond natural enzymes towards de novo designed and engineered variants for both natural and non‐natural compounds. Herein, we exploit the applicability of a de novo retro‐aldolase for the synthesis of sebacic acid, a valuable precursor for bio‐based polymers. From ricinoleic acid, a route composed of four individual enzyme‐catalyzed steps was developed. As a result of the narrow substrate scope of natural aldolases, this enzymatic route could only be realized by the design and engineering of a de novo retro‐aldolase. We further highlight the outstanding potential of this technology for the realization of non‐natural reactions and pathways.
Mikroben oxidieren Methan und reduzieren zugleich Metallkationen
Authors: Feil Sylvia 
Published: February 2017

AbstractErstmals konnte die anaerobe Oxidation von Methan durch Mikroorganismen in einer Süßwasserkultur verknüpft mit der Reduktion von Metallkationen durchgeführt werden. Dieser neu entdeckte Weg könnte ein Hinweis auf die frühesten Anpassungen des Lebens auf der Erde sein.
A simple authentication encryption scheme
Authors: Mazumder Rashed , Miyaji Atsuko , Su Chunhua 
Published: February 2017

SummaryAn authentication encryption (AE) scheme satisfies to transfer an authenticated data between 2 parties or more. There are vast applications of the AE such as access control, encryption, enhancing trust between multiple parties, and assure the originality of a message. However, the main challenge of the AE is to maintain low‐cost features for its construction. Furthermore, there is another emerging issue of Internet of Things (IoT) in the field of data and network communication. The numbers of application of the IoT are increasing expeditiously, where various kinds of device have been used such as IoT‐end device, constrained device, and RfID. Moreover, the main challenge of the IoT‐end devices and resource constrained devices is to keep a certain level of security bound including minimum cost. However, the IoT‐end devices, resource constrained devices, and RfID have lack of resources such as memory, power, and processors. Interestingly, the AE can play a vital role between data acquisition (sensors, actuators) and data aggregation of usual platform of the IoT. Thus, the construction of the AE should satisfy the properties of low‐cost, least resources, and less operating‐time. Though, there are many familiar constructions of AE such as OTR, McOE, POE, OAE, APE, COPE, CLOC, and SILK but most of the schemes depend on the features of nonce and associate data. In the aspect of security, the usage of nonce and associated data are adequate. However, these 2 features increase the overhead cost. Therefore, we propose a simple construction of IV‐based AE where blockcipher compression function is used as encryption function. Our proposed scheme's efficiency‐rate is 1 with reasonable privacy‐security bound. In addition, it can encrypt arbitrary length of message in each iteration without padding.