bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of Microstructural Evolution and Strain Analysis in SiOx/C Negative Electrodes Using In‐situ X‐ray Tomography and Digital Volume Correlation
Authors: Valisammagari Abhilash , Lachambre Joel , Adrien Jerome , Broche Ludovic , Petit Martin , Esnault Vivien , Maire Eric 
Published: September 2024

AbstractIncreasing the silicon content in batteries is expected to enhance their capacity. However, its implementation comes with challenges, as silicon exhibits a large volumetric expansion. This expansion is a significant factor contributing to the decreased lifespan of these batteries. One of the critical degradation mechanisms from a mechanical perspective is the delamination of electrode structure. The cyclability of these negative electrodes is noted to be influenced by the interaction between the binder and particles during battery cycling. The heavy local strain experienced by particles in these electrodes often leads to binder failure, resulting in particle isolation, detachment, or delamination over multiple cycles. A good understanding of the local evolution of the strain is essential in advancing the mechanical modelling of the degradation mechanism and in realizing the complete potential of silicon‐based electrodes. In this work, in situ global and local strain measurements were performed by combining synchrotron tomography with Digital Volume Correlation (DVC). The measurements showed that there is significant local strain in these electrodes which can lead to delamination. In addition to this, the spatial variability of the composite electrodes was characterized by estimating the characteristic length to strain, which can be used to replicate the strain field and model the delamination.
Can stable introns and noncoding RNAs be harnessed to improve health through activation of mitohormesis?
Authors: Chan Seow Neng , Pek Jun Wei 
Published: September 2024

AbstractEver since their introduction a decade ago, stable introns, a type of noncoding (nc)RNAs, are found to be key players in different important cellular processes acting through regulation of gene expression and feedback loops to maintain cellular homeostasis. Despite being commonly regarded as useless byproducts, recent studies in yeast suggested that stable introns are essential for cell survivability under starvation. In Drosophila, we found that a stable intron, sisR‐1, has a direct effect in regulating mitochondrial dynamics during short‐term fasting and subsequently improved overall oocyte quality. We speculated that the beneficial effects implicated by sisR‐1 is through the activation of mitohormesis, an interesting phenomenon in mitochondrial biology. Mitohormesis is suggested to improve health span and lifespan of cells and organisms, but the involvement of ncRNAs is not well‐documented. Here, we discuss the potential role of sisR‐1 and other ncRNAs in activating mitohormesis and the possible applications in improving cellular and organismal health.
Thiamine disulfide derivatives in thiol redox regulation: Role of thioredoxin and glutathione systems
Authors: Folda Alessandra , Scalcon Valeria , Tonolo Federica , Rigobello Maria Pia , Bindoli Alberto 
Published: September 2024

AbstractThiamine (vitamin B1), under the proper conditions, is able to reversibly open the thiazole ring, forming a thiol‐bearing molecule that can be further oxidized to the corresponding disulfide. To improve the bioavailability of the vitamin, several derivatives of thiamine in the thioester or disulfide form were developed and extensively studied over time, as apparent from the literature. We have examined three thiamine‐derived disulfides: thiamine disulfide, sulbutiamine, and fursultiamine with reference to their intervention in modulating the thiol redox state. First, we observed that both glutathione and thioredoxin (Trx) systems were able to reduce the three disulfides. In particular, thioredoxin reductase (TrxR) reduced these disulfides either directly or in the presence of Trx. In Caco‐2 cells, the thiamine disulfide derivatives did not modify the total thiol content, which, however, was significantly decreased by the concomitant inhibition of TrxR. When oxidative stress was induced by tert‐butyl hydroperoxide, the thiamine disulfides exerted a protective effect, indicating that the thiol form deriving from the reduction of the disulfides might be the active species. Further, the thiamine disulfides examined were shown to increase the nuclear levels of the transcription factor nuclear factor erythroid 2 related factor 2 and to stimulate both expression and activity of NAD(P)H quinone dehydrogenase 1 and TrxR. However, other enzymes of the glutathione and Trx systems were scarcely affected. As the thiol redox balance plays a critical role in oxidative stress and inflammation, the information presented can be of interest for further research, considering the potential favorable effect exerted in the cell by many sulfur compounds, including the thiamine‐derived disulfides.
Advances in early detection of non‐small cell lung cancer: A comprehensive review
Authors: Kenaan Nour , Hanna George , Sardini Moustafa , Iyoun Mhd Omar , Layka Khedr , Hannouneh Zein Alabdin , Alshehabi Zuheir 
Published: September 2024

AbstractBackgroundLung cancer has the highest mortality rate among malignancies globally. In addition, due to the growing number of smokers there is considerable concern over its growth. Early detection is an essential step towards reducing complications in this regard and helps to ensure the most effective treatment, reduce health care costs, and increase survival rates.AimsTo define the most efficient and cost‐effective method of early detection in clinical practice.Materials and MethodsWe collected the Information used to write this review by searching papers through PUBMED that were published from 2021 to 2024, mainly systematic reviews, meta‐analyses and clinical‐trials. We also included other older but notable papers that we found essential and valuable for understanding.ResultsEB‐OCT has a varied sensitivity and specificity—an average of 94.3% and 89.9 for each. On the other hand, detecting biomarkers via liquid biopsy carries an average sensitivity of 91.4% for RNA molecules detection, and 97% for combined methylated DNA panels. Moreover, CTCs detection did not prove to have a significant role as a screening method due to the rarity of CTCs in the bloodstream thus the need for more blood samples and for enrichment techniques.DiscussionAlthough low‐dose CT scan (LDCT) is the current golden standard screening procedure, it is accompanied by a highly false positive rate. In comparison to other radiological screening methods, Endobronchial optical coherence tomography (EB‐OCT) has shown a noticeable advantage with a significant degree of accuracy in distinguishing between subtypes of non‐small cell lung cancer. Moreover, numerous biomarkers, including RNA molecules, circulating tumor cells, CTCs, and methylated DNA, have been studied in the literature. Many of these biomarkers have a specific high sensitivity and specificity, making them potential candidates for future early detection approaches.ConclusionLDCT is still the golden standard and the only recommended screening procedure for its high sensitivity and specificity and proven cost‐effectiveness. Nevertheless, the notable false positive results acquired during the LDCT examination caused a presumed concern, which drives researchers to investigate better screening procedures and approaches, particularly with the rise of the AI era or by combining two methods in a well‐studied screening program like LDCT and liquid biopsy. we suggest conducting more clinical studies on larger populations with a clear demographical target and adopting approaches for combining one of these new methods with LDCT to decrease false‐positive cases in early detection.
Role of emotional control on anxiety and stress among cancer patients
Authors: Łuczyk Robert Jan , Sikora Kamil , Bodio Agnieszka , Łuczyk Marta , Baryła‐Matejczuk Monika , Wawryniuk Agnieszka , Sawicka Katarzyna , Zwolak Agnieszka 
Published: September 2024

AbstractObjectiveThe article aims to assess the role of stress and anxiety in relation to the level of emotional control among cancer patients. Currently cancer ranks second, after cardiovascular disease, as the most common cause of death. Moreover, it is predicted that in the coming years, cancer will become the leading cause of death worldwide. This is due to the extended lifespan of the population and also to the presence of carcinogenic factors in the surrounding environment. The emergence of cancer is a significant stressor that affects individuals in diverse ways, leading to cognitive, behavioral, and emotional consequences. In line with the adopted aim, emotional issues are the chosen area of exploration in this article.MethodsThe study included 102 patients. The differences between the patients' results according to various scales and the results produced by the validation group data were examined using one‐sample t‐tests. The relationships between the quantitative variables were determined using Spearman's rho coefficients, and the relationships between the quantitative and qualitative variables were verified using Kruskal‐Wallis tests.ResultsThe participants exhibited higher anxiety suppression levels than individuals in the normalization group. They sought emotional support more frequently than the average person in the population, turned to religion, engaged in other such activities, lived in denial more often, discontinued activities, and displayed a sense of humor less frequently. The more frequently they controlled their anger, the less they sought emotional and instrumental support, catharsis, and attempted to accept the situation and cease being active. Additionally, controlling anxiety, sadness, and depression coexisted with self‐blame, denial, and compensatory actions.ConclusionsCancer patients face intense anxiety. Emotional and instrumental support, along with the ability to express and manage emotions, are crucial for these patients, especially within the context of facing the challenge of cancer. Finding constructive ways to express strong and difficult emotions prevents their accumulation and reduces the need for emotional suppression. Preventive actions should be oriented toward supporting the emotional competencies of patients.
Aging‐related biomarkers in testicular cancer survivors after different oncologic treatments
Authors: Carballo‐Muñoz A. , Lima G. , Llorente L. , Remolina‐Bonilla Y. A. , Jaime‐Casas S. , Otamendi‐Lopez A. , Ortiz‐Guerra R. A. , Velazquez Hugo E. , Atisha‐Fregoso Y. , Bourlon M. T. 
Published: September 2024

AbstractPurposeTesticular cancer survivors (TCS) exposed to chemotherapy have an increased expression of CDKN2A/p16INK4a and a lymphocyte phenotype associated with immunosenescence. We seek to define whether the immunosenescent phenotype is associated with chemotherapy.MethodsCase–control study of TCS, disease‐free ≥3 months and stratified by primary treatment modality into orchiectomy only, chemotherapy, or bone marrow transplant (BMT). Each group was compared with age‐matched healthy controls (HC). We measured the relative proportions of lymphocyte subpopulations using flow cytometry, levels of C‐reactive protein, and relative expression of CDKN2A/p16INK4a quantified by qPCR.ResultsWe included 65 patients; 19 were treated with orchiectomy only, 35 received different doses of chemotherapy, and 11 underwent BMT. The chemotherapy and BMT groups had decreased naïve CD4 cells compared to HC. The chemotherapy group showed increased central and effector memory CD4 cells, as well as effector and terminally differentiated CD8 cells, compared to HC. Chemotherapy (chemotherapy 1.84 vs. HC 0.92; p < 0.01) and BMT (BMT 6.96 vs. HC 1.25; p < 0.005) groups had higher expression of CDKN2A/p16INK4a compared to HC. The orchiectomy group showed no significant difference with HC (orchiectomy 1.73 vs. HC 1.01; p = 0.17). CRP levels were higher in all groups when compared with HC; in the orchiectomy group, they were only marginally increased (chemotherapy 0.22 vs. HC 0.06; p < 0.01; BMT 0.26 vs. HC 0.06; p < 0.01; orchiectomy 0.09 vs. HC 0.07; p < 0.01).ConclusionsAmong TCS, only patients exposed to cytotoxic agents developed an immunosenescent phenotype. This finding supports the attribution of this alteration to the cytotoxic treatment.
Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma
Authors: Luo Zhuoyan , Lv Shiping , Lou Fangzhi , Yan Li , Xu Jingyi , Kang Ning , Dong Yunmei , Jin Xin 
Published: September 2024

AbstractBackgroundOral squamous cell carcinoma (OSCC) is the predominant form of head and neck cancer, often diagnosed at late stages, resulting in a poor prognosis. Recent studies indicate a potential association between OSCC and microbial presence. Microorganisms have been identified in various tumors and lesions, including OSCC and oral potentially malignant disorders (OPMDs). Intralesional microbiota are considered important components of the tumor microenvironment (TME) and may contribute to carcinogenesis.MethodsSources were collected through thorough searches of databases PubMed and Embase. The review focused on microbial characteristics, potential origins, and their impact on cancer progression.ResultsBacteria display varying abundance and diversity throughout the stages of OSCC and OPMDs. Intraleisional bacteria may have diverse sources, including not only oral plaque and saliva but also potentially the gut. Intralesional bacteria have both pro‐carcinogenic and anti‐carcinogenic effects, affecting processes like cell proliferation, invasion, and immune response.ConclusionsIntralesional microbiota are crucial in OSCC and OPMDs, influencing both disease progression and treatments. Despite their significance, challenges like inconsistent sampling and microbial identification remain. Future research is required to fully understand their role and improve clinical applications.
Consumer fantasies, feelings, fun …, and death? How mortality salience invokes consumers' fantastical thoughts about luxury products
Authors: Geiger‐Oneto Stephanie , Shehryar Omar 
Published: September 2024

AbstractPrevious research has demonstrated that the salience of one's mortality can influence the consumption of luxury goods because the higher monetary value of luxury goods pads one's self‐esteem which in turn assuages fear aroused by death thought accessibility. The present research presents an alternative explanation for this relationship by exploring the role of fantasy in the relationship between mortality salience and the preference for luxury goods. In four studies, we consistently find that consumers demonstrate a greater preference for luxury goods when their mortality is made salient (vs. control condition). In study 2, we extend previous research by utilizing fantasy engagement to demonstrate that increased preference for luxury goods following mortality salience is constructed through engagement in fantastical thinking. In study 3, we use fantasy proneness as an individual difference variable to show that together, a heightened awareness of mortality and a greater capacity for fantastical thinking lead to a greater preference for luxury goods. Finally, in study 4 we rule out alternative explanatory variables such as materialism and status‐based consumption to demonstrate that fantastical thinking mediates the relationship between death anxiety and evaluation of luxury goods whereas materialism and status‐based consumption do not elicit the same effect. Based on our findings we conclude that when existential concerns are activated, luxury goods allow for greater fantasy engagement than non‐luxury goods and that greater fantasy engagement increases preference for luxury goods. The theoretical and practical implications of our findings are discussed.
Phytochemical Study of Stachys iva Griseb. and In Vitro Evaluation of AhR Transcriptional Activity
Authors: Anagnostou Maria , Tomou Ekaterina‐Michaela , Goya‐Jorge Elizabeth , Chatzopoulou Paschalina , Giner Rosa María , Skaltsa Helen 
Published: September 2024

AbstractGenus Stachys L. consists of approximately 365 species, distributed mainly in temperate regions. Several members of this genus are widely used in the traditional medicine of different countries worldwide. In Greece, 54 Stachys taxa are found in parts of the mainland and/or insular country. The present study focused on the phytochemical investigation of Stachys iva Griseb. and the in vitro anti‐inflammatory evaluation of the isolated compounds. In total, eighteen compounds were isolated and identified from the dichloromethane‐methanol extract, belonging to iridoids, flavonoids, phenylethanoid glycosides, and phenolic acids. An in vitro approach assessed the aryl hydrocarbon receptor (AhR) modulatory effects of these compounds, revealing an AhR agonistic activity of the flavonoid aglycones apigenin and cirsimaritin in HepG2 and HT29 cell lines. The present study contributes to the evidence of the traditional uses of Stachys spp. and its bioactive constituents, justifying the ethnopharmacological use as an anti‐inflammatory plant genus.
New Antifungal and Antifeedant Metabolites from Daldinia Eschscholtzii Cocultured with Colletotrichum Pseudomajus
Authors: Chen Jing‐Xin , Yang Xue‐Qiong , Sun Jing , Li Yu‐He , Yang Ya‐Bin , Ding Zhong‐Tao 
Published: September 2024

AbstractThe synchronous co‐culture of Daldinia eschscholtzii and Colletotrichum pseudomajus produced one new linear polyketide, eschscholin C (1), along with three known compounds (2–4). One new acorane sesquiterpene, coldaldrin A (5), and one new amide derivative, coldaldamide A (6) as the probe for polyketide intermediate capture, and three known compounds (7–9) were isolated from the sequential co‐culture of D. eschscholtzii with C. pseudomajus. The structures and absolute configurations of 1, 5 and 6 were established by spectroscopic analysis including 1D, 2D NMR, the calculations of the NMR, and ECD data. Most compounds showed significant antifungal activities against the tea pathogens C. pseudomajus, and Fusarium asiaticum with MICs of 2–8 μg/mL. Compound 4 also showed antifeedant activity against silkworms with feeding deterrence indices of 79 % at the concentration of 50 μg/cm2.
Synthesis and In Vitro Antileishmanial Efficacy of Novel Ethylene Glycol Analogues of Benzothiadiazine‐1,1‐dioxide
Authors: Henning Nadine , Kannigadu Christina , Aucamp Janine , Janse van Rensburg Helena D. , van der Kooy Frank , N'Da David D. 
Published: September 2024

AbstractLeishmaniasis is a vector‐borne, parasitic disease affecting millions of people and animals worldwide. Current therapeutic options have proven to be ineffective in both treating the disease and preventing its spread. As a result, new drugs must be developed to effectively combat this disease. In this study, a series of 14 ethylene glycol analogues of benzothiadiazine‐1,1‐dioxide were synthesised to investigate their antileishmanial potential and cytotoxicity. Analogue 9, 2‐(2‐phenoxyethyl)‐2H‐benzo[e][1,2,4]thiadiazine‐1,1‐dioxide, was identified as the most inhibitory compound as it was observed to moderately inhibit the growth of L. major (IC50 103 μM) and L. donovani (IC50 153 μM) promastigotes. However, in general, the series presented with low biological activity, which may be attributed to reduced target affinity and/or undesired cell culture protein binding.
Synthesis and Antiproliferative Activity of Cisplatin‐3–Chloropiperidine Conjugates
Authors: Georg Mats , Legin Anton A. , Hejl Michaela , Jakupec Michael A. , Becker Jonathan , Göttlich Richard 
Published: September 2024

AbstractWe report the synthesis and characterization of two novel cisplatin‐ alkylating agents conjugates. Combining a platinum based cytostatic agent with a sterically demanding alkylating agent could potentially induce further DNA damage, block cell repair mechanisms and keep the substrate active against resistant tumor cell lines. The 3‐chloropiperidines utilized as ligands in this work are cyclic representatives of the N‐mustard family and were not able to coordinate platinum on their own. The introduction of a second coordination site, in form of a pyridine moiety, led to the isolation of the desired conjugates. They were characterized with HRMS, CHN‐analyses and XRD. We concluded this work by examining the cytotoxicity of the ligands and the obtained complexes with MTT assays in human cancer cell lines. While the ligands showed hardly any activity, the novel conjugates both displayed a high antiproliferative and cytotoxic potency in a panel of three cell lines. Moreover, both complexes were able to largely circumvent the acquired cisplatin resistance of A2780cisR ovarian cancer cells, both in the MTT assay and a flow‐cytometric apoptosis assay.
The significance of therapeutic drug monitoring in detecting low medication adherence in patients with cancer: A case study of cabozantinib
Authors: Maruyama Shinichi , Momo Kenji , Anno Tadatsugu , Ishida Masaru , Kanno Hiroshi , Kato Masaru 
Published: September 2024

Key Clinical MessageMaintaining good medication adherence is important for providing desirable outcomes from medication therapy. We showed that therapeutic drug monitoring (TDM) contributed to the identification of low medication adherence to cabozantinib in a patient with cancer. We present an educational case to assist with understanding TDM in a patient with cancer.
Low Temperature Sabatier CO2 Methanation
Authors: Molinet‐Chinaglia Clément , Shafiq Seema , Serp Philippe 
Published: September 2024

AbstractThe CO2 methanation reaction, or Sabatier reaction, is experiencing renewed interest in the context of large‐scale recycling of point CO2 emissions, leading to the power‐to‐gas technology. The reaction represents a flexible route to transform CO2 into methane by hydrogenation with (green) dihydrogen. This exothermic transformation takes place at a reasonable rate at temperatures above 200 °C and is directed to the targeted product at low temperatures. The CO2 methanation nevertheless remains kinetically limited due to the chemical stability of CO2 and the high bond dissociation energy for C═O in CO2. Therefore, the current urgent demand is for the development of catalysts and associated processes with superior activity for CO2 activation at low temperatures. This critical review aims to overview the state of the art of this low‐temperature technology using thermal, plasma and photo‐assisted catalysis. We summarize research advances around low‐temperature CO2 methanation, focusing on catalyst formulations (metal, supports and promoters), reaction mechanisms and suitable activation processes. We discuss each of these critical aspects of the technology and identify the main challenges and opportunities for low temperature (≤200 °C) CO2 methanation.