bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional vision and cognition in infants with congenital disorders of the peripheral visual system
Authors: Dale Naomi , Sakkalou Elena , O'Reilly Michelle , Springall Clare , De Haan Michelle , Salt Alison 
Published: April 2017

AimTo investigate how vision relates to early development by studying vision and cognition in a national cohort of 1‐year‐old infants with congenital disorders of the peripheral visual system and visual impairment.MethodThis was a cross‐sectional observational investigation of a nationally recruited cohort of infants with ‘simple’ and ‘complex’ congenital disorders of the peripheral visual system. Entry age was 8 to 16 months. Vision level (Near Detection Scale) and non‐verbal cognition (sensorimotor understanding, Reynell Zinkin Scales) were assessed. Parents completed demographic questionnaires.ResultsOf 90 infants (49 males, 41 females; mean 13mo, standard deviation [SD] 2.5mo; range 7–17mo); 25 (28%) had profound visual impairment (light perception at best) and 65 (72%) had severe visual impairment (basic ‘form’ vision). The Near Detection Scale correlated significantly with sensorimotor understanding developmental quotients in the ‘total’, ‘simple’, and ‘complex’ groups (all p<0.001). Age and vision accounted for 48% of sensorimotor understanding variance. Infants with profound visual impairment, especially in the ‘complex’ group with congenital disorders of the peripheral visual system with known brain involvement, showed the greatest cognitive delay.InterpretationLack of vision is associated with delayed early‐object manipulative abilities and concepts; ‘form’ vision appeared to support early developmental advance. This paper provides baseline characteristics for cross‐sectional and longitudinal follow‐up investigations in progress. A methodological strength of the study was the representativeness of the cohort according to national epidemiological and population census data.
Retail Investor Attention and IPO Valuation
Authors: Colaco Hugh M. J. , De Cesari Amedeo , Hegde Shantaram P. 
Published: April 2017

AbstractGiven restrictions placed on communication with prospective investors, retail investor attention can help firms/underwriters with the task of initially valuing an IPO. Using Google search volume to proxy for retail investor attention, we find that the presence of and an increase in retail attention following initial filing but prior to initial pricing are positively related to initial valuations. Our results are robust to alternative matching methods to identify our matched sample of non‐IPO firms and to including several controls for institutional demand. We conclude that retail investor attention plays a critical role in the early stages of IPO valuation.
Intelligent heart disease prediction in cloud environment through ensembling
Authors: Gupta Nishant , Ahuja Naman , Malhotra Shikhar , Bala Anju , Kaur Gurleen 
Published: April 2017

AbstractCloud computing is the delivery of on‐demand computing resources. Cloud computing has numerous applications in fields of education, social networking, and medicine. But the benefit of cloud for medical purposes is seamless, particularly because of the enormous data generated by the health care industry. This colossal data can be managed through big data analytics, and hidden patterns can be extracted using machine learning procedures. In particular, the latest issue in the medical domain is the prediction of heart diseases, which can be resolved through culmination of machine learning and cloud computing. Hence, an attempt has been made to propose an intelligent decision support model that can aid medical experts in predicting heart disease based on the historical data of patients. Various machine learning algorithms have been implemented on the heart disease dataset to predict accuracy for heart disease. Naïve Bayes has been selected as an effective model because it provides the highest accuracy of 86.42% followed by AdaBoost and boosted tree. Further, these 3 models are being ensembled, which has increased the overall accuracy to 87.91%. The experimental results have also been evaluated using 10,082 instances that clearly validate the maximum accuracy through ensembling and minimum execution time in cloud environment.
An assessment of spatio‐temporal variability of land surface temperature using MODIS data: A study of Gujarat state, India
Authors: Patel Shashikant , Joshi Janak P. , Bhatt Bindu 
Published: April 2017

AbstractLand surface temperature (LST) is temperature of the skin surface of land, which can be derived from satellite information or direct measurements. Satellite data provide consistent, continuous, and spatially distributed information on the Earth's surface conditions. The moderate resolution imaging spectro‐radiometer instruments installed on the Aqua and Terra Earth observation satellites from NASA, have provided MOD11A2 Product, which contains daytime and nighttime LST in 1 km spatial resolution. Short‐term mean (STM) has been calculated using the daytime LST (2002–2011). LST for year 2012, 2013, and 2014 has been analyzed with reference to STM. The study has been carried out for summer season (March to June) that is also called as premonsoon season. Results show that the district of Saurashtra and Ahmadabad experience high LST during summer as compared to districts of South Gujarat. LST analysis is carried out at district and taluka level for entire Gujrat state. Twenty‐five districts in Gujarat state contains 179 talukas. Study aims to assess inter and intra‐annual and seasonal variability in LST time series data and explores the variation in STM LST and trends in the Gujarat state. The results showed that in 2012 was normal in terms of LST for the summer season, but in the year 2013 experienced above normal or higher LST as compare to STM in almost entire Gujarat during summer season. The analysis showed that the year 2014 summer season also experienced very high LST as compare to the STM. In the year 2013, months of March, April, May, and June, LST is higher than STM in 81, 38, 139, and 43 talukas, respectively.
Is humidified better than non‐humidified low‐flow oxygen therapy? A systematic review and meta‐analysis
Authors: Wen Zunjia , Wang Wenting , Zhang Haiying , Wu Chao , Ding Jianping , Shen Meifen 
Published: April 2017

AbstractAimsTo determine the effects of low‐flow oxygen therapy with humidified or non‐humidified oxygen in adult patients.BackgroundAlthough non‐humidified oxygen in low‐flow oxygen therapy is recommended by many guidelines, humidifying oxygen regardless of oxygen flow has been routinely performed in China and Japan and further studies are needed to evaluate the evidence.DesignA systematic review and meta‐analysis that comply with the recommendations of the Cochrane Collaboration were conducted.Data sourcesStudies (1980–2016) were identified by searching PUBMED, EMBASE, Science Direct, Cochrane library, CNKI and Wanfang Database.MethodsWe performed a comprehensive, systematic meta‐analysis of randomized controlled trials on the efficacy of humidified and non‐humidified low‐flow oxygen therapy. Summary risk ratios or weighted mean differences with 95% confidence intervals were calculated using a fixed‐ or random‐effects model.ResultsTwenty‐seven randomized controlled trials with a total number of 8,876 patients were included. Non‐humidified oxygen offers more benefits in reducing the bacterial contamination of humidifier bottles, as shown by the mean operating time for oxygen administration and the respiratory infections compared with humidified oxygen therapy. No significant differences were found in dry nose, dry nose and throat, nosebleed, chest discomfort, the smell of oxygen and SpO2 changes.ConclusionsThe routine humidification of oxygen in low‐flow oxygen therapy is not justifiable and non‐humidified oxygen tends to be more beneficial. However, considering that the quality of most included studies is poor, rigorously designed, large‐scale randomized controlled trials are still needed to identify the role of non‐humidified oxygen therapy.
Qualitative research in teen experiences living with food‐induced anaphylaxis: A meta‐aggregation
Authors: Johnson Sara F. , Woodgate Roberta L. 
Published: April 2017

AbstractAimTo describe the central experiences of teens living with food‐induced anaphylaxis as a first step in responding to healthcare needs in this population.BackgroundAs prevalence of allergy increases and commonly outgrown allergies persist longer, chronic management for teens becomes increasingly important. Synthesizing existing research helps to recognize management needs specific to teens with food allergy.DesignMeta‐aggregation for qualitative systematic review, to create synthesis for clinical improvement; guided by Joanna Briggs Institute methods and their Qualitative Assessment and Review Instrument.Data sourcesSeven relevant databases were searched for original qualitative research July 2015; 10 studies (published 2007–2015) met inclusion criteria.Review methodsBoth authors undertook critical appraisal, with consensus by discussion. Findings from line‐by‐line extraction were grouped into categories and syntheses. In studies with mixed populations, we included only teens (age 12–19) with food‐induced anaphylaxis.ResultsWe developed three syntheses from nine categories and 64 subcategories to reflect central experiences of teens with food‐induced anaphylaxis, including: (1) defining the allergic self; (2) finding a balance and (3) controlling the uncontrollable. The syntheses encompass importance of allergic identity/understanding, difficulties in coping with burdens of food allergy and reflect the complex risk interactions teens must negotiate in social contexts.ConclusionThere is a need to respect teens as active participants in managing food‐induced anaphylaxis, while recognizing that social expectations and a lack of public awareness/safety can dangerously affect one's needs and decisions. This helps broaden how we conceptualize the needs of teens living with food‐induced anaphylaxis, informing ongoing care and management.
Impaired endothelial function in patients with cryptogenic stroke and patent foramen ovale is not affected by closure
Authors: Lantz Maria , Kostulas Konstantinos , Settergren Magnus , Sjöstrand Christina 
Published: April 2017

IntroductionPatent foramen ovale (PFO) is associated with cryptogenic stroke (CS) and migraine with aura (MA). Endothelial dysfunction (ED) is a risk factor for development of cardiovascular disease, but might also be involved in migraine pathophysiology. Short‐term worsening of migraine has been described after closure of PFO. We evaluated endothelial function in patients with CS and PFO, before and after closure of PFO, and in patients with migraine, whether changes in endothelial function was related to a change in migraine frequency.Material and MethodsPatients with CS and PFO were included; 20 with planned closure of PFO and seven controls on medical treatment only. Endothelial function was assessed by peripheral arterial tonometry (EndoPatR) and biomarkers of endothelial activation. Patients were followed longitudinally at baseline, day 1, 1 month, and 6 months. A headache diary was used to assess migraine frequency.ResultMean age of the cohort was 45.4 years, and migraine prevalence was 50% whereof 84.6% had MA. Median EndoPatR index (RHI) at baseline was 1.60 (IQR 1.41‐2.00). There was no change in RHI over time, either in closure patients (P = 0.66), nor in controls (P = 0.31), and there was no change in biomarkers of endothelial activation. Three migraine patients experienced worsening of migraine frequency directly after closure.DiscussionEndothelial function did not change after closure of PFO. Although patients were lacking cardiovascular risk factors, a high proportion had impaired endothelial function. Whether ED can have predictive value, identifying PFO at higher risk for recurrent stroke warrants further investigations.
Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways
Authors: Majidinia Maryam , Sadeghpour Alireza , Mehrzadi Saeed , Reiter Russel J. , Khatami Nasrin , Yousefi Bahman 
Published: April 2017

AbstractDNA repair is responsible for maintaining the integrity of the genome. Perturbations in the DNA repair pathways have been identified in several human cancers. Thus, compounds targeting DNA damage response (DDR) hold great promise in cancer therapy. A great deal of effort, in pursuit of new anticancer drugs, has been devoted to understanding the basic mechanisms and functions of the cellular DNA repair machinery. Melatonin, a widely produced indoleamine in all organisms, is associated with a reduced risk of cancer and has multiple regulatory roles on the different aspects of the DDR and DNA repair. Herein, we have mainly discussed how defective components in different DNA repair machineries, including homologous recombination (HR), nonhomologous end‐joining (NHEJ), base excision repair (BER), nucleotide excision repair (NER), and finally DNA mismatch repair (MMR), can contribute to the risk of cancer. Melatonin biosynthesis, mode of action, and antioxidant effects are reviewed along with the means by which the indoleamine regulates DDR at the transduction, mediation, and functional levels. Finally, we summarize recent studies that illustrate how melatonin can be combined with DNA‐damaging agents to improve their efficacy in cancer therapy.
Second Language Users’ Restriction of Linguistic Generalization Errors: The Case of English Un– Prefixation Development
Authors: Zhang Xiaopeng 
Published: April 2017

AbstractThis study adopted Ambridge's research paradigm to examine the effects of entrenchment, preemption, and verb semantics in second language (L2) acquisition of English un– prefixation. Three groups of Chinese learners of English (second‐ and fourth‐year English majors and teachers of English) rated the acceptability of 48 un– prefixed verbs and their bare forms. Frequency of bare forms (e.g., close) was a factor associated with the preference of the fourth‐year learners and the teachers to reject ungrammatical un– verbs (e.g., unclose). However, competing forms (e.g., open) did not appear to be linked to participants’ judgments of the acceptability of ungrammatical un– verbs, lending support to the entrenchment rather than the preemption hypothesis. Ratings of the extent to which verbs incorporate the semantics of un– verbs emerged as significant predictors for the fourth‐year learners’ and the teachers’ judgements of the acceptability of grammatical un– verbs, supporting the semantic verb class hypothesis.Open PracticesThis article has been awarded an Open Materials badge. All materials are publicly accessible in the IRIS digital repository at http://www.iris-database.org. Learn more about the Open Practices badges from the Center for Open Science: https://osf.io/tvyxz/wiki.
Navigating Stigma and Group Conflict: Group Identification as a Cause and Consequence of Self‐Labeling
Authors: Whitson Jennifer , Anicich Eric M. , Wang Cynthia S. , Galinsky Adam D. 
Published: April 2017

AbstractA crucial element of navigating group conflict is how group members manage stigma imposed on them by other groups. Across three experiments, we propose that group identification is a cause and consequence of self‐labeling with stigmatizing group labels, a practice known to reduce stigma. Experiment 1 found that group identification increased self‐labeling with a stigmatizing group label. In Experiment 2, individuals who self‐labeled with a stigmatizing group label felt more identified with their group, which reduced the label's perceived negativity; they also persisted longer on an in‐group helping task, an effect that was partially mediated by group identification. In Experiment 3, observers perceived self‐labelers as more identified with their group and as viewing the label less negatively; perceived group identification mediated the relationship. Group identification is a critical component in reappropriating stigmatizing labels and provides insight into how highly identified members can navigate group conflict by negotiating their group's identity.
Impulsivity, communication, and marital satisfaction in newlywed couples
Authors: TAN KENNETH , JARNECKE AMBER M. , SOUTH SUSAN C. 
Published: April 2017

AbstractThe authors used a vulnerability–stress–adaptation framework to examine how and why impulsivity affects communication and marital satisfaction in a sample of 100 newlywed couples. We specifically examined the links between impulsivity and perceptions of conflict communication patterns and their associations with marital satisfaction. Using an actor–partner interdependence framework, the results demonstrated that impulsivity was negatively associated with one's own and partner's marital satisfaction. Impulsivity was also negatively associated with constructive communication and positively associated with destructive communication. Furthermore, mediation analyses showed that communication patterns mediated the impulsivity–satisfaction link. Taken together, these findings suggest that impulsivity is likely to lead to lower marital satisfaction, partly through its effect on communication between partners.
Photophysical Characterization of the Naturally Occurring Dioxobacteriochlorin Tolyporphin A and Synthetic Oxobacteriochlorin Analogues
Authors: Hood Don , Niedzwiedzki Dariusz M. , Zhang Ran , Zhang Yunlong , Dai Jingqiu , Miller Eric S. , Bocian David F. , Williams Philip G. , Lindsey Jonathan S. , Holten Dewey 
Published: April 2017

AbstractTolyporphins are tetrapyrrole macrocycles produced by a cyanobacterium‐containing culture known as HT‐58‐2. Tolyporphins A–J are free base dioxobacteriochlorins, whereas tolyporphin K is an oxochlorin. Here, the photophysical characterization is reported of tolyporphin A and two synthetic analogues, an oxobacteriochlorin and a dioxobacteriochlorin. The characterization (in toluene, diethyl ether, ethyl acetate, dichloromethane, 1‐pentanol, 2‐butanone, ethanol, methanol, N,N‐dimethylformamide and dimethylsulfoxide) includes static absorption and fluorescence spectra, fluorescence quantum yields and time‐resolved data. The data afford the lifetime of the lowest singlet excited state and the yields of the nonradiative decay pathways (intersystem crossing and internal conversion). The three macrocycles exhibit only modest variation in spectroscopic and excited‐state photophysical parameters across the solvents. The long‐wavelength (Qy) absorption band of tolyporphin A appears at ~680 nm and is remarkably narrow (full‐width‐at‐half‐maximum ~7 nm). The position of the long‐wavelength (Qy) absorption band of tolyporphin A (~680 nm) more closely resembles that of chlorophyll a (662 nm) than bacteriochlorophyll a (772 nm). The absorption spectra of tolyporphins B–I, K (which were available in minute quantities) are also reported in methanol; the spectra of B–I closely resemble that of tolyporphin A. Taken together, tolyporphin A generally exhibits spectral and photophysical features resembling those of chlorophyll a.
Balancing task focus and relationship building: asking sleepy patients about traffic risk in treatment initiation consultations
Authors: Iversen Clara , Broström Anders , Ulander Martin 
Published: April 2017

BackgroundThe use of traffic risk assessment questions is an understudied area in nursing research. Obstructive sleep apnoea is associated with an increased risk of traffic accidents. Therefore, traffic safety authorities demand adherent continuous positive airway pressure use. Nurses act as coaches to achieve treatment adherence, but they are also obliged to act as state agents by prohibiting obstructive sleep apnoea patients from drowsy driving.ObjectiveTo examine how nurses and obstructive sleep apnoea patients manage traffic risk assessment questions in the relation‐building context of treatment initiation consultations.MethodsTo study, in detail, the actual practice of risk assessment, we used conversation analysis of 19 video‐recorded initial treatment consultations with nurses and recently diagnosed obstructive sleep apnoea patients.EthicsThe study received ethical approval from the Central Ethical Review Board in Linköping (registration number 214/231‐32) and follows the ethical guidelines for qualitative research.ResultsPatients influence how nurses phrase questions about traffic risk by taking a stance to daytime sleepiness prior to the risk question. Nurses ask traffic risk questions in a way that assumes that driving is unproblematic if patients have not previously indicated problems. It may pose a significant problem when nurses, by accepting patients’ prior stance when asking about traffic risk, orient to relationship building rather than task focus.ConclusionTo clarify the difference between their two potentially conflicting roles, nurses need to refer to existing laws and official guidelines when they raise the issue of risk in treatment initiation consultations. Nurses should also ask risk assessment questions in a problem‐oriented communicative environment. Traffic risk assessment is sensitive yet important, as obstructive sleep apnoea is a highly prevalent problem causing excessive sleepiness. It is essential to acknowledge nurses’ double roles with regard to coaching continuous positive airway pressure treatment and assessing traffic risk.
Impact of obstructive sleep apnoea and intermittent hypoxia on cardiovascular and cerebrovascular regulation
Authors: Beaudin Andrew E. , Waltz Xavier , Hanly Patrick J. , Poulin Marc J. 
Published: April 2017

New Findings
What is the topic of this review?
This review examines the notion that obstructive sleep apnoea (OSA) and intermittent hypoxia (IH) have hormetic effects on vascular health.

What advances does it highlight?
Clinical (OSA patient) and experimental animal and human models report that IH is detrimental to vascular regulation. However, mild IH and, by extension, mild OSA also have physiological and clinical benefits. This review highlights clinical and experimental animal and human data linking OSA and IH to vascular disease and discusses how hormetic effects of OSA and IH relate to OSA severity, IH intensity and duration, and patient/subject age.

Obstructive sleep apnoea (OSA) is associated with increased risk of cardiovascular and cerebrovascular disease, a consequence attributed in part to chronic intermittent hypoxia (IH) resulting from repetitive apnoeas during sleep. Although findings from experimental animal, and human, models have shown that IH is detrimental to vascular regulation, the severity of IH used in many of these animal studies [e.g. inspired fraction of oxygen () = 2–3%; oxygen desaturation index = 120 events h−1] is considerably greater than that observed in the majority of patients with OSA. This may also explain disparities between animal and recently developed human models of IH, where IH severity is, by necessity, less severe (e.g. = 10–12%; oxygen desaturation index = 15–30 events h−1). In this review, we highlight the current knowledge regarding the impact of OSA and IH on cardiovascular and cerebrovascular regulation. In addition, we critically discuss the recent notion that OSA and IH may have hormetic effects on vascular health depending on conditions such as OSA severity, IH intensity and duration, and age. In general, data support an independent causal link between OSA and vascular disease, particularly for patients with severe OSA. However, the data are equivocal for older OSA patients and patients with mild OSA, because advanced age and short‐duration, low‐intensity IH have been reported to provide a degree of protection against IH and ischaemic events such as myocardial infarction and stroke, respectively. Overall, additional studies are needed to investigate the beneficial/detrimental effects of mild OSA on the various vascular beds.