bluuebunny/crossref_metadata_2025_split huggingface dataset:
Utilizing Game Online to Enhance University Student’s Speaking Skill
Authors: Zumam Wildona , Alfarozi Rikzen 
Published: October 2024

Abstract: Speaking is complex skill that express the ideas, opinions, desires, our feelings freely, structured and spontaneously that aim give or get information and knowledge from other people. The speaking process base on experiences that can be obtained through discussion, reading, observation, and listening. All the students want to speak English fluently; therefore students must learn to boost their speaking skills. Talking about speaking boosting, the boosting is divided into several aspects ranging from boosting pronunciation, comprehension, grammar, and vocabulary. It can be used as a measurement our speaking is good or not. Almost all students have method to boosting English speaking skill namely online game. The students was familiar with gadgets rarely have online games, not only one but more online games on one gadget. This researcher have research the student of English department in academic year 2017-2020 with using interview method. The result of the study is can boost speaking skill but not effective to be Media learning in English program students Madura University. Abstrak: Berbicara adalah keterampilan kompleks yang mengungkapkan gagasan, pendapat, keinginan, perasaan kita secara bebas, terstruktur dan spontan yang bertujuan memberi atau mendapatkan informasi dan pengetahuan dari orang lain. Proses berbicara didasarkan pada pengalaman yang dapat diperoleh melalui diskusi, membaca, observasi, dan mendengarkan. Semua siswa ingin berbicara bahasa Inggris dengan lancar; oleh karena itu siswa harus belajar untuk meningkatkan keterampilan berbicara mereka. Berbicara tentang peningkatan berbicara, peningkatan dibagi menjadi beberapa aspek mulai dari peningkatan pengucapan, pemahaman, tata bahasa, dan kosa kata. Hal ini dapat digunakan sebagai ukuran baik atau tidaknya berbicara kita. Hampir semua siswa memiliki metode untuk meningkatkan keterampilan berbicara bahasa Inggris yaitu game online. Siswa yang akrab dengan gadget jarang memiliki game online, tidak hanya satu game online tetapi lebih pada satu gadget. Peneliti ini melakukan penelitian terhadap mahasiswa jurusan Bahasa Inggris tahun ajaran 2017-2020 dengan menggunakan metode wawancara. Hasil penelitian dapat meningkatkan keterampilan berbicara tetapi tidak efektif menjadi media pembelajaran pada mahasiswa program studi Bahasa Inggris Universitas Madura.
Factors Affecting The Bajo Tribe Construction of Children’s Education In Sapeken Islands
Authors: Supianto Supianto 
Published: October 2024

Abstract: Equitable access for education can be a measure of a country's justice. Although almost all countries, including Indonesia, have echoed campaigns on education for all, this has not always been successful. Various obstacles were faced, such as socio-cultural constraints, especially for isolated tribes. This study aims to determine the factors that influence parents' construction in the Bajo Tribe towards children's education in the Sapeken Islands. This research is qualitative research with a phenomenological method. The study was conducted for one year with ten subjects. Data was obtained through participatory observation, then analyzed using the NVivo program. The results show that at least five factors influence the construct of Bajo parents on their children's education. The five factors include religious and moral values, relations with the outside world, availability of transportation facilities, educational facilities, and access to information. Abstrak: Pemerataan akses pendidikan dapat menjadi ukuran keadilan suatu negara. Meskipun hampir semua negara, termasuk Indonesia, telah menggemakan kampanye pendidikan untuk semua, namun hal ini tidak selalu berhasil. Berbagai kendala dihadapi, seperti kendala sosial budaya, terutama bagi suku terasing. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang mempengaruhi pembinaan orang tua Suku Bajo terhadap pendidikan anak di Kepulauan Sapeken. Penelitian ini merupakan penelitian kualitatif dengan metode fenomenologis. Penelitian dilakukan selama satu tahun dengan sepuluh subjek. Data diperoleh melalui observasi partisipatif, kemudian dianalisis menggunakan program NVivo. Hasil penelitian menunjukkan bahwa setidaknya ada lima faktor yang mempengaruhi konstruk orang tua Bajo terhadap pendidikan anaknya. Kelima faktor tersebut antara lain nilai agama dan moral, hubungan dengan dunia luar, ketersediaan sarana transportasi, sarana pendidikan, dan akses informasi.
Penerapan Kombinasi Model Pembelajaran Discovery Learning dan Problem Solving Pada Pembelajaran Ekonomi
Authors: Rahmawati Santi Dwi , Hidayat Taufiq 
Published: October 2024

Abstrack: This study aims to describe the application of a combination of Discovery Learning and Problem Solving learnig models in economics class VIII MTs Thoriqotul Falah. This research is a qualitative research using a descriptive method . Population in this study amounted to 28 students. Data collection using observation, interviews, and documentation. The results of this study indicate that process of learning activities by applying a combination of Discovery Learning and Problem Solving runs well and smoothly. Learning by applying this learning models is effective and fun. This is evidenced from the evaluation method through student learning outcomes tests and student perceptions which state that 89.3% strongly agree and 10,7 % agree that learning by applying a combination of learning models is effectively used in the teaching and learning process. Abstrak: Penelitian ini bertujuan untuk mendeskripsikan penerapan kombinasi model pembelajaran Discovery Learning dan Problem Solving pada pembelajaran ekonomi kelas VIII MTs Thoriqotul Falah. Penelitian ini merupakan penelitian kualitatif dengan menggunakan metode deskriptif. Populasi pada penelitian ini berjumlah 28 siswa. Pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa proses kegiatan pembelajaran dengan menerapkan kombinasi model pembelajaran Discovery Learning dan Problem Solving berjalan dengan baik dan lancar. Pembelajaran dengan menerapkan model pembelajaran ini efektif digunakan dan menyenangkan. Hal ini dibuktikan dari cara evaluasi dengan melalui tes hasil belajar siswa dan persepsi siswa yang menyatakan bahwa 89,3 % sangat setuju dan 10,7 % setuju bahwa pembelajaran dengan menerapkan kombinasi model pembelajaran ini efektif digunakan dalam proses belajar mengajar.
Forecasting Traffic and Toll Revenue for Kathmandu-Terai/Madhesh Fast Track Expressway
Authors: Lamsal Sandesh , Khatiwada Purushartha , Pradananga Rojee , Shrestha Pradeep Kumar , Marsani Anil 
Published: October 2024

Analysis of traffic forecasting and toll revenue projections for the Kathmandu-Terai/Madhesh Fast Track (KTFT) Expressway, which is Nepal's first Expressway connecting Kathmandu to Nijgadh. The analysis involves an Origin-Destination survey, traffic assignments and projections, and an evaluation of toll earnings. Traffic assignment of the existing traffic between Kathmandu various regional zones in Nepal shows an estimated 40% diversion of traffic to the KTFT Expressway. Utilising daily volume records of Department of Roads (DoR) for Nagdhunga and Banepa Bardibas highway sections, a projected daily traffic volume of 11957 passenger car unit (PCU) was determined for the base year 2024. Traffic forecasts for 2035, 2045 and 2055 were made by projecting the base year traffic and considering a generated traffic of 30% of the diverted traffic for each subsequent year. Growth rates for different vehicle types were projected using elasticity method with GDP as an indicator. The total daily traffic projected for 2035, 2045 and 2055 is 30922 PCU, 48789 PCU and 70724 PCU, respectively representing approximately 2.59, 4.08, 5.91 times the base year volume. A toll pricing structure, in accordance with the guidelines in the National Highway Fee Rules (NHFR-2008) has been proposed. Under this toll structure, projected daily total revenue for years 2035, 2045, and 2055 are estimated to be NRs 60.53 lakhs, NRs 160.62 lakhs, and NRS 251.40 lakhs, respectively. Comparison of this revenue with the construction and maintenance costs of the project indicates an estimated payback period of 35 years to break even on the construction cost.
Derechos humanos, educación y género: Reflexiones universitarias desde la metodología del aprendizaje basado en investigación
Authors: Salgado Guifarro Onix Alejandra 
Published: October 2024

La educación superior en Honduras enfrenta múltiples desafíos debido al contexto social que afecta a su entorno y, por ende, a sus estudiantes. Esto exige que dichas instituciones asuman un papel protagónico en la identificación y el abordaje de las realidades territoriales, a través de prácticas de enseñanza-aprendizaje que promuevan la investigación y participación del universitario en la construcción de conocimiento, para su sensibilización y la acción de mejora en su medio. El objetivo de la presente investigación es reflejar el análisis de los estudiantes de Relaciones Internacionales de la Universidad Tecnológica Centroamericana sobre la perspectiva de derechos humanos, educación y género contemplada en el Plan de Gobierno para Refundar Honduras 2022-2026, usando herramientas de metodología del aprendizaje basado en investigación. El estudio se desarrolló en la asignatura Gestión de la Cooperación y Ayuda Humanitaria, en la que dieciséis estudiantes participaron en revisiones documentales, diagramas de árbol, grupos focales, análisis FODA y la elaboración de un artículo de opinión como proyecto final. Esta experiencia educativa subrayó la importancia de cooperar y crear espacios de investigación vinculados a la realidad hondureña para promover la libertad académica dentro del aula con dinámicas activas, incluyendo la evaluación de contenidos temáticos y la comprensión de la normativa vigente y su impacto real en la sociedad. Además, la propuesta fomenta la práctica autodidacta, al permitir a los estudiantes asumir la responsabilidad y autonomía en su aprendizaje. El docente, por su parte, tiene un rol crucial en la guía y el apoyo para el desarrollo de estas habilidades.
FRANKIANA BY YURII MEZHENKO
Authors: Holiak Tetiana 
Published: October 2024

The name of the prominent scholar Yurii Mezhenko is not commonly associated with the achievements of Franko studies. However, the figure of Ivan Franko was within the scope of Mezhenko’s professional interests, as evidenced by the bibliography of his research, diary entries, and letters. Mezhenko’s most significant contribution to Franko studies is an index to the literary, artistic, social, and political journal “Life and Word” (“Zhytie i Slovo”), which was published from 1894 to 1897 under the editorship of Ivan Franko. This index, co-authored with Yaroslav Dashkevych, has remained unpublished. Halyna Svarnyk and Nadiya Strishenets mentioned Mezhenko’s work on it, but the detailed history of its preparation has never been the subject of a scholarly research. This study is based on Yu. Mezhenko’s published correspondence and archival materials from the collections of Shevchenko Institute of Literature of the National Academy of Sciences of Ukraine and the Central State Archive-Museum of Literature and Art of Ukraine. The research employs various methods, including source analysis, textual analysis, historical and literary analysis. By examining the published correspondence and archival materials, the study reconstructs the sequence of events and uncovers the reasons behind the project’s failure.
The idea for this work originated with Yu. Mezhenko in 1958. After being invited to collaborate, Ya. Dashkevych helped in uncovering pseudonyms and cryptonyms and wrote an introductory article. Thus, as Yu. Mezhenko emphasized, it was a joint project. The index was intended for publication in the journal “Soviet Literary Studies” (“Radianske literaturoznavstvo”), but the plan was not realized. Efforts to publish it in the Lviv yearbook “Ivan Franko” were also unsuccessful. The manuscript of the work is now preserved in the archival collection of Yurii Mezhenko. A systematic index to the contents of “Zhytie i Slovo,” compiled by Petro Babiak and edited by Mykhailo Humeniuk, was eventually published in 1968.
The impact of anesthesia clerkship training on procedural timing: a focus on medical students in anesthesiology
Authors: Chatmongkolchart Sunisa , Saetang Mantana , Kunapaisal Thitikan , Yongsata Dararat , Saelim Kantaros 
Published: October 2024

IntroductionThe impact of medical student involvement in anesthetic procedures on operating room (OR) efficiency and patient outcomes remains understudied, despite its importance in medical education. This study aimed to quantify the effects of fifth-year medical students’ participation in anesthetic procedures on key time metrics, perceived difficulty, procedural success, and postoperative complications and to compare these effects with those of anesthetic residents and student nurse anesthetists.MethodsThis prospective observational study was conducted between April and July 2022 in the OR of a tertiary university hospital in southern Thailand. We analyzed 111 elective obstetric-gynecologic and general surgery procedures under subarachnoid block or general anesthesia, equally distributed among three groups: fifth-year medical students, anesthetic residents, and student nurse anesthetists. Key time intervals, perceived difficulty, number of attempts, success rates, and postoperative complications were recorded and compared across groups.ResultsFifth-year medical students exhibited significantly prolonged anesthesia release time, anesthesia-controlled time, anesthetic preparation time, and anesthetic procedure time compared to anesthetic residents and student nurse anesthetists (p &lt; 0.05). Medical students perceived case inductions as more challenging than the other groups did (p &lt; 0.001), but procedural success rates were comparable across groups. Immediate postoperative airway complications were more frequent among medical students than anesthetic residents, but no significant differences were found in intraoperative or 24-h postoperative complications.DiscussionWhile the involvement of medical students in anesthetic procedures extends specific time metrics, it does not significantly impact overall case duration or major patient outcomes. These findings support the continued integration of medical student training in the OR, with appropriate supervision to manage the slightly increased risk of immediate postoperative complications. Further research is needed to optimize the balance between educational opportunities and OR efficiency.Clinical trial registrationhttps://www.thaiclinicaltrials.org/show/TCTR20220418006, identifier TCTR20220418006.
Use of connected injection device has a positive effect on catch-up growth in patients with growth disorders treated with growth hormone therapy
Authors: de Arriba Antonio , van Dommelen Paula , Savage Martin O. 
Published: October 2024

IntroductionHuman growth hormone (hGH) therapy in children can be administered by subcutaneous injection using either a manual non-connected device, which is a portable injection pen loaded with a pre-filled cartridge, or an electronic connected device. The electronic device is connected to a platform where adherence data is recorded and available for health care professionals (HCPs) and patient support programs. Real-world data used in the clinic, includes regular monitoring of adherence data which are shared with families during patients’ visits and aim to determine the root causes of poor adherence. This study aimed to identify whether there are differences in growth during the first four years of treatment depending on the device, i.e. non-connected versus connected devices.MethodsThis retrospective study reports treatment of either GH deficiency or short stature secondary to birth size small for gestational age (SGA) in 174 pediatric patients attending Miguel Servet Hospital, Zaragoza, Spain. hGH treatment was administered with manual non-connected devices in 87 patients and 87 patients used connected devices. Height was followed for 4 years after start of hGH therapy.ResultsIn total, 57% of subjects had GHD and 43% were SGA. Height standard deviation score (HSDS) at treatment start was higher (p&lt;0.001) in the non-connected device group compared to the connected device group. Change of HSDS in the connected device group was significantly higher in the second (+0.13), third (+0.20) and fourth (+0.23) year of treatment compared to the non-connected group after adjustment for age and HSDS at treatment start, sex, indication, dose and Tanner stages during treatment, and timing of measurements.DiscussionThese results support the use of the connected device for hGH treatment of pediatric growth disorders.
Dynamic roles of neutrophil extracellular traps in cancer cell adhesion and activation of Notch 1-mediated epithelial-to-mesenchymal transition in EGFR-driven lung cancer cells
Authors: Dimitrov Jelena , Maddalena Maurizio , Terlizzi Cristina , Altobelli Giovanna G. , Pellegrino Sara , Mehmood Tayyaba , De Rosa Viviana , Iommelli Francesca , Del Vecchio Silvana 
Published: October 2024

IntroductionNeutrophil extracellular traps (NETs) are complex structures released by activated neutrophils that may modulate different steps of the metastatic cascade. The aim of our study was to investigate how NETs can modulate the adhesion properties of cancer cells and whether cell exposure to NETs can activate the epithelial-to-mesenchymal transition (EMT) program thus enhancing the migratory and invasive properties of tumor cells.Materials and methodsDifferent cancer cell lines were subjected to a solid-phase adhesion assay using NET-coated plates with or without the addition of antibodies against α5β1 or CCDC25 receptor. After 1-4 h of incubation, adherent cells were expressed as the percentage of total cell number. To test EMT occurrence, cells were treated with NETs for up to 48 h and then the levels of E-cadherin, vimentin, Snail, Slug, Zeb 1 and Twist 1 along with levels of Notch 1 and cleaved Notch 1 were determined by western blotting. Untreated and NET-treated cells were subjected to migration assays using 24-multiwell plates with transwell and FBS as chemoattractant.ResultsCancer cell adhesion to NET-coated plates varied between 30% and 92.7% and was significantly higher than that obtained in uncoated plates. The addition of antibodies against α5β1 or CCDC25 caused a strong reduction of cell adhesion to NETs. The prolonged exposure of EGFR-driven cancer cell lines to NETs caused the activation of the EMT program through the upregulation and cleavage of Notch 1 and was confirmed by the enhanced expression of EMT markers. The consequent loss of the epithelial phenotype induced a strong reduction of the expression of the oncogene driver. Cell migration was significantly enhanced in NET-treated cells as compared to untreated cells.DiscussionOur findings reveal the dynamic role of NETs that may provide a DNA and fibronectin rich environment for binding of many cancer cells at distant sites where the prolonged exposure to NETs triggers the EMT through the activation of Notch 1 signaling pathway with the subsequent enhancement of migratory and invasive properties of cancer cells. Furthermore, our findings provide an example of how an immune/inflammatory microenvironment may directly modulate the sensitivity of cancer cells to oncogene targeted agents.
A hybrid machine learning model combining association rule mining and classification algorithms to predict differentiated thyroid cancer recurrence
Authors: Firat Atay Feyza , Yagin Fatma Hilal , Colak Cemil , Elkiran Emin Tamer , Mansuri Nasrin , Ahmad Fuzail , Ardigò Luca Paolo 
Published: October 2024

BackgroundDifferentiated thyroid cancer (DTC) is the most prevalent endocrine malignancy with a recurrence rate of about 20%, necessitating better predictive methods for patient management. This study aims to create a relational classification model to predict DTC recurrence by integrating clinical, pathological, and follow-up data.MethodsThe balanced dataset comprises 550 DTC samples collected over 15 years, featuring 13 clinicopathological variables. To address the class imbalance in recurrence status, the Synthetic Minority Over-sampling Technique for Nominal and Continuous (SMOTE-NC) was utilized. A hybrid model combining classification algorithms with association rule mining was developed. Two relational classification approaches, regularized class association rules (RCAR) and classification based on association rules (CBAR), were implemented. Binomial logistic regression analyzed independent predictors of recurrence. Model performance was assessed through accuracy, sensitivity, specificity, positive predictive value, negative predictive value, and F1 score.ResultsThe RCAR model demonstrated superior performance over the CBAR model, achieving accuracy, sensitivity, and F1 score of 96.7%, 93.1%, and 96.7%, respectively. Association rules highlighted that papillary pathology with an incomplete response strongly predicted recurrence. The combination of incomplete response and lymphadenopathy was also a significant predictor. Conversely, the absence of adenopathy and complete response to treatment were linked to freedom from recurrence. Incomplete structural response was identified as a critical predictor of recurrence risk, even with other low-recurrence conditions.ConclusionThis study introduces a robust and interpretable predictive model that enhances personalized medicine in thyroid cancer care. The model effectively identifies high-risk individuals, allowing for tailored follow-up strategies that could improve patient outcomes and optimize resource allocation in DTC management.
Exploring genetic determinants of antimicrobial resistance in Brucella melitensis strains of human and animal origin from India
Authors: Ayoub Haris , Kumar M. Suman , Mehta Rishabh , Thomas Prasad , Dubey Muskan , Dhanze Himani , Ajantha Ganavalli S. , Bhilegaonkar K. N. , Salih Harith M. , Cull Charley A. , Veeranna Ravindra P. , Amachawadi Raghavendra G. 
Published: October 2024

IntroductionAntimicrobial resistance (AMR) in Brucella melitensis, the causative agent of brucellosis, is of growing concern, particularly in low and middle-income countries. This study aimed to explore the genetic basis of AMR in B. melitensis strains from India.MethodsTwenty-four isolates from humans and animals were subjected to antimicrobial susceptibility testing and whole-genome sequencing.ResultsResistance to doxycycline (20.80%), ciprofloxacin (16.67%), cotrimoxazole (4.17%), and rifampicin (16.67%) was observed. Genome analysis revealed efflux-related genes like mprF, bepG, bepF, bepC, bepE, and bepD across all isolates, however, classical AMR genes were not detected. Mutations in key AMR-associated genes such as rpoB, gyrA, and folP were identified, intriguingly present in both resistant and susceptible isolates, suggesting a complex genotype–phenotype relationship in AMR among Brucella spp. Additionally, mutations in efflux genes were noted in resistant and some susceptible isolates, indicating their potential role in resistance mechanisms. However, mutations in AMR-associated genes did not consistently align with phenotypic resistance, suggesting a multifactorial basis for resistance.DiscussionThe study underscores the complexity of AMR in B. melitensis and advocates for a holistic multi-omics approach to fully understand resistance mechanisms. These findings offer valuable insights into genetic markers associated with AMR, guiding future research and treatment strategies.