bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultural Variations in Reasons for Advice Seeking
Authors: Ji Li‐Jun , Zhang Ning , Li Ye , Zhang Zhiyong , Harper Gillian , Khei Mark , Li Jie 
Published: October 2016

AbstractFive studies examined cultural differences in reasons for advice‐seeking behaviors. Content analyses in Study 1A and self‐ratings in Study 1B consistently revealed that Euro‐Canadians were more likely than East Asians (mainly Chinese) to seek advice for informational reasons, whereas East Asians were more likely than Euro‐Canadians to seek advice for relational reasons. Study 2A showed that Chinese displayed a higher level of relationship concern than Euro‐Canadians in deciding from whom to seek advice in a decision dilemma. Study 2B found that, although Chinese and Euro‐Canadians did not differ from each other on willingness to pay for informational advice, Chinese were willing to pay more for building a relationship with the advisor through advice seeking than Euro‐Canadians were. Study 3 explored how the advice giver might perceive an advice seeker in terms of their competence and the closeness of their relationship after advice was sought for various reasons. We found that relationally oriented advice seeking increased the perceived competence of the advice seeker among Chinese more than among Euro‐Canadians. Information‐oriented advice seeking increased the perceived closeness between the advice seeker and advice giver among Chinese more than among Euro‐Canadians. Implications for other aspects of advice exchange are discussed. Copyright © 2016 John Wiley & Sons, Ltd.
Scientific Writing Made Easy: A Step‐by‐Step Guide to Undergraduate Writing in the Biological Sciences
Authors: Turbek Sheela P. , Chock Taylor M. , Donahue Kyle , Havrilla Caroline A. , Oliverio Angela M. , Polutchko Stephanie K. , Shoemaker Lauren G. , Vimercati Lara 
Published: October 2016

AbstractScientific writing, while an indispensable step of the scientific process, is often overlooked in undergraduate courses in favor of maximizing class time devoted to scientific concepts. However, the ability to effectively communicate research findings is crucial for success in the biological sciences. Graduate students are encouraged to publish early and often, and professional scientists are generally evaluated by the quantity of articles published and the number of citations those articles receive. It is therefore important that undergraduate students receive a solid foundation in scientific writing early in their academic careers. In order to increase the emphasis on effective writing in the classroom, we assembled a succinct step‐by‐Step guide to scientific writing that can be directly disseminated to undergraduates enrolled in biological science courses. The guide breaks down the scientific writing process into easily digestible pieces, providing concrete examples that students can refer to when preparing a scientific manuscript or laboratory report. By increasing undergraduate exposure to the scientific writing process, we hope to better prepare undergraduates for graduate school and productive careers in the biological sciences.
Online optimal experimental re‐design in robotic parallel fed‐batch cultivation facilities
Authors: Cruz Bournazou M.N. , Barz T. , Nickel D.B. , Lopez Cárdenas D.C. , Glauche F. , Knepper A. , Neubauer P. 
Published: October 2016

ABSTRACTWe present an integrated framework for the online optimal experimental re‐design applied to parallel nonlinear dynamic processes that aims to precisely estimate the parameter set of macro kinetic growth models with minimal experimental effort. This provides a systematic solution for rapid validation of a specific model to new strains, mutants, or products. In biosciences, this is especially important as model identification is a long and laborious process which is continuing to limit the use of mathematical modeling in this field. The strength of this approach is demonstrated by fitting a macro‐kinetic differential equation model for Escherichia coli fed‐batch processes after 6 h of cultivation. The system includes two fully‐automated liquid handling robots; one containing eight mini‐bioreactors and another used for automated at‐line analyses, which allows for the immediate use of the available data in the modeling environment. As a result, the experiment can be continually re‐designed while the cultivations are running using the information generated by periodical parameter estimations. The advantages of an online re‐computation of the optimal experiment are proven by a 50‐fold lower average coefficient of variation on the parameter estimates compared to the sequential method (4.83% instead of 235.86%). The success obtained in such a complex system is a further step towards a more efficient computer aided bioprocess development. Biotechnol. Bioeng. 2017;114: 610–619. © 2016 Wiley Periodicals, Inc.
Anatomical versus non-anatomical liver resection for hepatocellular carcinoma exceeding Milan criteria
Authors: Li S-Q , Huang T , Shen S-L , Hua Y-P , Hu W-J , Kuang M , Peng B-G , Liang L-J 
Published: October 2016

Abstract

Background
Liver resection is effective for hepatocellular carcinoma (HCC) exceeding the Milan criteria in selected patients. However, the benefit of anatomical resection (AR) versus non-anatomical resection (NAR) has not been clarified in this patient subgroup. This study aimed to compare outcomes between AR and NAR for HCC exceeding the Milan criteria.

Methods
Data on consecutive patients with HCC exceeding the Milan criteria who underwent liver resection with curative intent over a recent 6-year interval were extracted from a prospective single-centre HCC database and examined retrospectively. The postoperative outcomes of patients were compared before and after propensity score matching.

Results
Some 546 patients were included: 264 in the AR and 282 in the NAR group. In the original cohort, the AR group contained more patients with larger tumours, multiple tumours, macroscopic portal vein tumour thrombi, incomplete tumour capsules and microscopic vascular invasion. After propensity score matching, 177 pairs of patients were selected. The baseline data, including liver function and tumour burden, were similar in the matched groups. The 3-year recurrence-free survival rate was comparable between the matched NAR and AR groups (36·5 versus 28·5 per cent; P = 0·448). Similar results were observed for 3-year overall survival (57·5 versus 50·3 per cent; P = 0·385), recurrence patterns and early recurrence rates (57·6 per cent versus 59·9 per cent; P = 0·712).

Conclusion
AR and NAR achieved favourable and similar outcomes for HCC exceeding the Milan criteria in selected patients.
The disappearance rate and risk assessment of thiacloprid residues in Asian pear using liquid chromatography confirmed with tandem mass spectrometry
Authors: Kabir Md. Humayun , Abd El‐Aty A.M. , Rahman Md. Musfiqur , Kim Sung‐Woo , Choi Jeong‐Heui , Lee Young‐Jun , Truong Lieu T.B. , Lee Kang‐Bong , Kim Mi‐Ra , Shin Ho‐Chul , Shim Jae‐Han 
Published: October 2016

AbstractThis study was undertaken to quantify the residue levels and propose the dissipation kinetics of thiacloprid formulated as suspension concentrate in field‐incurred Asian pears grown under two different open‐field conditions. Samples were extracted with 20% distilled water in acetonitrile; partitioned with brine water and dichloromethane; and purified with a Florisil solid phase extraction cartridge. The analyte was identified with an LC ultraviolet detector, and field‐incurred samples were confirmed using LC–MS/MS. The calibration curve was linear over the range 0.05–5.0 mg/L with a satisfactory coefficient of determination (R2 = 0.9994). The limits of detection and limits of quantification (LOQ) were 0.003 and 0.01 mg/kg, respectively. The recovery rate fortified to blank samples at LOQ, 10× LOQ, and the maximum residue limit (MRL) were between 73.7 and 86.2% with relative standard deviation ≤9.0%. The residual concentrations at both sites were considerably lower than the MRL (0.7 mg/kg) set by the Korean Ministry of Food Drug Safety, with biological half‐lives of 5.0 and 7.4 days, for sites 1 and 2, respectively. From the pre‐harvest residue limit curve, it was predicted that if the residues were <1.13 or 1.40 mg/kg 10 days before harvest, the residue level would be lower than the MRL during harvest. Risk assessment on day 0 showed an acceptable daily intake (%) of 13.0% and 11.0% for sites 1 and site 2, respectively, which indicates that the residual amounts are not hazardous to the Korean population.
German Electricity Balancing Market for Small Manure Plants
Authors: Jung Rolf , Weger Andreas , Stenzel Fabian , Gasson James Richard 
Published: October 2016

AbstractIn order to exploit the theoretical potential of small manure anaerobic digestion (AD) plants for flexible power generation, the technical retrofitting and the prospective additional revenue generated by direct marketing is assessed for two different manure AD plants by means of a profitability analysis. Due to the variation in the economic profitability by the individual direct marketing models, the economy of three plants was simulated in four different scenarios: basic feed‐in tariff, direct marketing, electricity balancing market, and flexible operation. Economical operations were calculated and the additional revenue for small manure AD plants taking part in the direct marketing system was calculated.
Comprehensive Understanding of Structure‐Controlling Factors of a Zinc Tetraphenylporphyrin Thin Film Using pMAIRS and GIXD Techniques
Authors: Hada Miyako , Shioya Nobutaka , Shimoaka Takafumi , Eda Kazuo , Hada Masahiko , Hasegawa Takeshi 
Published: October 2016

AbstractThe performance of an organic electronic device is significantly influenced by the anisotropic molecular structure in the film, which has long been difficult to predict especially for a solution process. In the present study, a zinc tetraphenylporphyrin (ZnTPP) thin film prepared by a solution process was chosen to comprehensively explore the molecular‐arrangement mechanism as a function of representative film‐preparation parameters: solvent, film‐preparation technique, and thermal annealing. The anisotropic structure was first analyzed by using a combination of infrared p‐polarized multiple‐angle incidence resolution spectrometry (pMAIRS) and grazing incidence X‐ray diffraction (GIXD), which readily revealed the molecular orientation and crystal structure, respectively. As a result, the real dominant factor was found to be the evaporation time of the solvent that determines the initial two different molecular arrangements, types‐I and ‐II, while the thermal annealing was found to play an additional role of improving the molecular order. The correlation between the molecular orientation and the crystal structure was also revealed through the individual orientation analysis of the porphyrin and phenyl rings.
Ligand and Metal Effects on the Stability and Adsorption Properties of an Isoreticular Series of MOFs Based on T‐Shaped Ligands and Paddle‐Wheel Secondary Building Units
Authors: Xiong Ying , Fan Yan‐Zhong , Damasceno Borges Daiane , Chen Cheng‐Xia , Wei Zhang‐Wen , Wang Hai‐Ping , Pan Mei , Jiang Ji‐Jun , Maurin Guillaume , Su Cheng‐Yong 
Published: October 2016

AbstractThe synthesis of stable porous materials with appropriate pore size and shape for desired applications remains challenging. In this work a combined experimental/computational approach has been undertaken to tune the stability under various conditions and the adsorption behavior of a series of MOFs by subtle control of both the nature of the metal center (Co2+, Cu2+, and Zn2+) and the pore surface by the functionalization of the organic linkers with amido and N‐oxide groups. In this context, six isoreticular MOFs based on T‐shaped ligands and paddle‐wheel units with ScD0.33 topology have been synthesized. Their stabilities have been systematically investigated along with their ability to adsorb a wide range of gases (N2, CO2, CH4, CO, H2, light hydrocarbons (C1–C4)) and vapors (alcohols and water). This study has revealed that the MOF frameworks based on Cu2+ are more stable than their Co2+ and Zn2+ analogues, and that the N‐oxide ligand endows the MOFs with a higher affinity for CO2 leading to excellent selectivity for this gas over other species.
Modelling and experimental validation of a CO2 methanation annular cooled fixed‐bed reactor exchanger
Authors: Ducamp Julien , Bengaouer Alain , Baurens Pierre 
Published: October 2016

AbstractA simulation model of a fixed‐bed reactor‐exchanger dedicated to CO2 methanation on an industrial Ni/γ‐Al2O3 catalyst has been built on the basis of experimental characterization of heat transfer and kinetic parameters. An effective thermal conductivity of the bed and a wall heat transfer coefficient are determined from cooling experiments of different Ar‐H2 mixtures (thermal conductivity 0.02–0.25 W · m−1 · K−1) at different Reynolds numbers (particle Reynolds number 1–50). The flow dependent component of the Nusselt number correlates to the gas Prandtl number as Pr0.72. These heat transfer parameters and a kinetic model adapted to the Ni/γ‐Al2O3 catalyst are integrated in mass, heat, and momentum balance equations in the bed and at the particle scale to build a 2D heterogeneous model of the fixed‐bed reactor. CO2 methanation experiments in an annular fixed‐bed reactor‐exchanger filled with 400 g of Ni/γ‐Al2O3 catalyst at pressures from 0.4 to 0.8 MPa and coolant temperatures from 473 to 548 K (200 to 275 °C) are described in this paper and simulated by the model.CO2 conversion rate and CH4 selectivity at the reactor outlet and temperature elevations in the reactor are simulated by the model with a discrepancy lower than 10 %. For pressures above 0.4 MPa, a strong mass diffusion limitation inside the catalyst particles is shown and the efficiency decrease of the three reactions is explained.
A phase 2 study of nanoparticle albumin‐bound paclitaxel plus nedaplatin for patients with advanced, recurrent, or metastatic cervical carcinoma
Authors: Li Yifan , Zeng Jing , Huang Manni , An Jusheng , Bai Ping , Wu Lingying , Zhang Rong 
Published: October 2016

BACKGROUNDNanoparticle albumin‐bound paclitaxel (nab‐paclitaxel) and nedaplatin (NDP) are used for the treatment of patients with cervical cancer. However, to the authors’ knowledge, the use of this combination regimen among patients with advanced, recurrent, or metastatic cervical cancer has rarely been reported.METHODSPatients with pathologically confirmed, stage IVB (FIGO staging 2009), recurrent or metastatic cervical cancer were eligible. Nab‐paclitaxel at a dose of 175 mg/m2 plus NDP at a dose of 80 mg/m2 was administered intravenously every 3 weeks. The primary endpoint of the current study was the objective response rate (ORR). The secondary endpoints were progression‐free survival, overall survival, and safety.RESULTSA total of 27 patients were included (5 with late‐stage and 22 with recurrent or metastatic disease). The mean age of the patients was 48.26 ± 9.21 years. Of these 27 patients, 25 had squamous cell carcinoma (92.6%). A total of 26 patients completed 92 cycles of chemotherapy, with an average of 3.4 cycles per patient. The ORR was 50.0% (13 of 26 patients). The overall survival was 16.6 months (95% confidence interval, 12.6‐20.6 months) and the progression‐free survival was 9.1 months (95% confidence interval, 2.4‐15.8 months).The ORR of patients with an interval of >12 months from receipt of prior chemotherapy was significantly higher than that of those with a shorter interval (71.4% vs 25.0%; P = .034). The most common adverse effects reported were myelosuppression, gastrointestinal reactions, fatigue, and peripheral neuropathy. The incidence of grade 3 neutropenia was 33.3% (adverse effects were graded on a scale from 0 to 4 according to the National Cancer Institute's Common Terminology Criteria for Adverse Events [version 3.0]). The incidence of grade 3 thrombocytopenia and anemia was 7.4% and 18.5%, respectively. The incidence of grade 1 to 2 peripheral neuropathy was reported to be as high as 51.9%. No case of hypersensitivity was observed.CONCLUSIONSThe combination of nab‐paclitaxel plus NDP for the treatment of patients with late‐stage, recurrent, or metastatic cervical cancer appears to be active and tolerable. Cancer 2017;123:420–425. © 2016 American Cancer Society.
Phase 2 study of dasatinib in patients with alveolar soft part sarcoma, chondrosarcoma, chordoma, epithelioid sarcoma, or solitary fibrous tumor
Authors: Schuetze Scott M. , Bolejack Vanessa , Choy Edwin , Ganjoo Kristen N. , Staddon Arthur P. , Chow Warren A. , Tawbi Hussein A. , Samuels Brian L. , Patel Shreyaskumar R. , von Mehren Margaret , D'Amato Gina , Leu Kirsten M. , Loeb David M. , Forscher Charles A. , Milhem Mohammed M. , Rushing Daniel A. , Lucas David R. , Chugh Rashmi , Reinke Denise K. , Baker Laurence H. 
Published: October 2016

BACKGROUNDAlveolar soft part sarcoma (ASPS), chondrosarcoma (CS), chordoma, epithelioid sarcoma, and solitary fibrous tumor (SFT) are malignant tumors that are relatively resistant to chemotherapy and for which more effective drug therapy is needed.METHODSThe 5 listed subtypes were enrolled into a single indolent sarcoma cohort in a phase 2 study of dasatinib using a Bayesian continuous monitoring rule for enrollment. The primary objective was to estimate the 6‐month progression‐free survival (PFS) rate according to the Choi criteria with a target of ≥50%. Cross‐sectional imaging was performed before the start of treatment, every 2 months for 6 months, and then every 3 months during treatment. The 2‐ and 5‐year survival rates were determined.RESULTSOne hundred sixteen patients were enrolled within 45 months, and 109 began treatment with dasatinib. The 6‐month PFS rate and the median PFS were 48% and 5.8 months, respectively. The PFS rate at 6 months was highest with ASPS (62%) and lowest with SFT (30%). More than 10% of the patients with ASPS, CS, or chordoma had stable disease for more than 1 year. Collectively, for all 5 subtypes, the 2‐ and 5‐year overall survival rates were 44% and 13%, respectively. An objective response was observed in 18% of the patients with CS or chordoma.CONCLUSIONSDasatinib failed to achieve control of sarcoma growth for at least 6 months in more than 50% of the patients in this trial according to the Choi tumor response criteria. An objective tumor response and prolonged stable disease was observed in >10% of patients with CS or chordoma. Cancer 2017;90–97. © 2016 American Cancer Society.
Surface topography during neural stem cell differentiation regulates cell migration and cell morphology
Authors: Czeisler Catherine , Short Aaron , Nelson Tyler , Gygli Patrick , Ortiz Cristina , Catacutan Fay Patsy , Stocker Ben , Cronin James , Lannutti John , Winter Jessica , Otero José Javier 
Published: October 2016

ABSTRACTWe sought to determine the contribution of scaffold topography to the migration and morphology of neural stem cells by mimicking anatomical features of scaffolds found in vivo. We mimicked two types of central nervous system scaffolds encountered by neural stem cells during development in vitro by constructing different diameter electrospun polycaprolactone (PCL) fiber mats, a substrate that we have shown to be topographically similar to brain scaffolds. We compared the effects of large fibers (made to mimic blood vessel topography) with those of small‐diameter fibers (made to mimic radial glial process topography) on the migration and differentiation of neural stem cells. Neural stem cells showed differential migratory and morphological reactions with laminin in different topographical contexts. We demonstrate, for the first time, that neural stem cell biological responses to laminin are dependent on topographical context. Large‐fiber topography without laminin prevented cell migration, which was partially reversed by treatment with rock inhibitor. Cell morphology complexity assayed by fractal dimension was inhibited in nocodazole‐ and cytochalasin‐D–treated neural precursor cells in large‐fiber topography, but was not changed in small‐fiber topography with these inhibitors. These data indicate that cell morphology has different requirements on cytoskeletal proteins dependent on the topographical environment encountered by the cell. We propose that the physical structure of distinct scaffolds induces unique signaling cascades that regulate migration and morphology in embryonic neural precursor cells. J. Comp. Neurol. 524:3485–3502, 2016. © 2016 Wiley Periodicals, Inc.
Polyelectrolyte‐Brush‐Derived Nitrogen‐Doped Porous Carbon
Authors: Li Xiaofeng , Zhang Fangfang , Yuan Jiao , Zhang Haining , Pan Mu , Huang Chi , Tang Haolin 
Published: October 2016

AbstractNitrogen‐doped porous carbons have been well‐recognized as promising materials for a wide range of applications. Therefore, the rational design and synthesis of nitrogen‐doped porous carbons are essential both for practical applications as well as for understanding of their fundamental properties. In this Communication, we report a silica‐template‐assisted fabrication of nitrogen‐doped porous carbons through pyrolysis of polyelectrolyte brushes. The resulting material has a surface area of 799 m2 g−1 and exhibits improved electrochemical catalytic ability towards the oxygen reduction reaction in basic medium and an increased carbon dioxide adsorption capability compared with samples derived from a physical mixture of polyelectrolyte and silica, although the latter sample has higher overall nitrogen content. The findings in this work provide a new strategy to fabricate nitrogen‐doped porous carbon not only for practical applications, but also as a model system for fundamental understanding of the correlation between heteroatom distribution and properties.
The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms
Authors: Mouchiroud Laurent , Sorrentino Vincenzo , Williams Evan G. , Cornaglia Matteo , Frochaux Michael V. , Lin Tao , Nicolet‐dit‐Félix Amandine A. , Krishnamani Gopal , Ouhmad Tarik , Gijs Martin A.M. , Deplancke Bart , Auwerx Johan 
Published: October 2016

AbstractPhenotyping strategies in simple model organisms such as D. melanogaster and C. elegans are often broadly limited to growth, aging, and fitness. Recently, a number of physical setups and video tracking software suites have been developed to allow for accurate, quantitative, and high‐throughput analysis of movement in flies and worms. However, many of these systems require precise experimental setups and/or fixed recording formats. We report here an update to the Parallel Worm Tracker software, which we termed the Movement Tracker. The Movement Tracker allows variable experimental setups to provide cross‐platform automated processing of a variety of movement characteristics in both worms and flies and permits the use of simple physical setups that can be readily implemented in any laboratory. This software allows high‐throughput processing capabilities and high levels of flexibility in video analysis, providing quantitative movement data on C. elegans and D. melanogaster in a variety of different conditions. © 2016 by John Wiley & Sons, Inc.