bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Carbide Precipitation in Low-Carbon Martensitic Steels Using an Ultrawide Field-of-View 3D Atom Probe
Authors: Minami Hidekazu , Tegg Levi , Sato Takanori , Cairney Julie M 
Published: September 2024

Abstract
It is important to understand the carbide distribution around high-energy sites such as dislocations and grain boundaries in martensitic steels as they have a major influence on the alloy performance. The aim of this study is to characterize fine ε carbides precipitated in low-carbon lath martensitic steel using the ultrawide field-of-view (FoV) CAMECA Invizo 6000 atom probe. We demonstrate the advantages of the wide FoV and determine the optimum conditions for analysis, by comparing the results such as the background noise and the C++/C+ charge state ratio (CSR) between voltage-pulsed and laser-pulsed modes. Increasing the laser pulse energy decreased the background noise and the CSR, where 70 pJ laser pulse energy produced a comparable mass-to-charge ratio spectrum to that recorded in voltage-pulsed mode, with the bulk compositions of C, Si, and Mn closest to that measured using voltage-pulsed mode. Increasing laser pulse energies to above 300 pJ decreased the bulk carbon content, with a more diffuse distribution of carbon around the carbides. This paper outlines some of the important experimental considerations when performing quantitative study of carbide precipitation in low-carbon martensitic steels using the Invizo 6000, considerations that can also be applied to other ferrous and non-ferrous alloy systems.
Horseshoes and spiral waves: capturing the 3D flow induced by a low-mass planet analytically
Authors: Brown Joshua J , Ogilvie Gordon I 
Published: September 2024

ABSTRACT
The key difficulty faced by 2D models for planet–disc interaction is in appropriately accounting for the impact of the disc’s vertical structure on the dynamics. 3D effects are often mimicked via softening of the planet’s potential; however, the planet-induced flow and torques often depend strongly on the choice of softening length. We show that for a linear adiabatic flow perturbing a vertically isothermal disc, there is a particular vertical average of the 3D equations of motion that exactly reproduces 2D fluid equations for arbitrary adiabatic index. There is a strong connection here with the Lubow–Pringle 2D mode of the disc. Correspondingly, we find a simple, general prescription for the consistent treatment of planetary potentials embedded within ‘2D’ discs. The flow induced by a low-mass planet involves large-scale excited spiral density waves that transport angular momentum radially away from the planet and ‘horseshoe streamlines’ within the coorbital region. We derive simple linear equations governing the flow that locally capture both effects faithfully simultaneously. We present an accurate coorbital flow solution allowing for inexpensive future study of corotation torques, and predict the vertical structure of the coorbital flow and horseshoe region width for different values of adiabatic index, as well as the vertical dependence of the initial shock location. We find strong agreement with the flow computed in 3D numerical simulations, and with 3D one-sided Lindblad torque estimates, which are a factor of 2–3 lower than values from previous 2D simulations.
Mechanism of activation of contact-dependent growth inhibition tRNase toxin by the amino acid biogenesis factor CysK in the bacterial competition system
Authors: Feng Zhaohang , Yashiro Yuka , Tomita Kozo 
Published: September 2024

Abstract
Contact-dependent growth inhibition (CDI) is a bacterial competition mechanism, wherein the C-terminal toxin domain of CdiA protein (CdiA-CT) is transferred from one bacterium to another, impeding the growth of the toxin recipient. In uropathogenic Escherichia coli 536, CdiA-CT (CdiA-CTEC536) is a tRNA anticodon endonuclease that requires a cysteine biogenesis factor, CysK, for its activity. However, the mechanism underlying tRNA recognition and cleavage by CdiA-CTEC536 remains unresolved. Here, we present the cryo-EM structure of the CysK:CdiA-CTEC536:tRNA ternary complex. The interaction between CdiA-CTEC536 and CysK stabilizes the CdiA-CTEC536 structure and facilitates tRNA binding and the formation of the CdiA-CTEC536 catalytic core structure. The bottom-half of the tRNA interacts exclusively with CdiA-CTEC536 and the α-helices of CdiA-CTEC536 engage with the minor and major grooves of the bottom-half of tRNA, positioning the tRNA anticodon loop at the CdiA-CTEC536 catalytic site for tRNA cleavage. Thus, CysK serves as a platform facilitating the recognition and cleavage of substrate tRNAs by CdiA-CTEC536.
Is Kenya’s gender wealth gap narrowing? New insights from probate records
Authors: Simson Rebecca 
Published: September 2024

Abstract
This article introduces a new dataset on individuals leaving inheritances in Kenya, which sheds light on the country’s marked gender disparities in the ownership of wealth. An estimated 9% of decedents in Kenya leave estates that undergo probate or administration. Since the 1980s, men have been four times more likely than women to leave such estates at death. But this gender estate gap has been narrowing. The share of women leaving wealth at death has risen from below 10% in the 1970s to 25% today. The geographic variation in this gender estate gap shows that women are more likely to leave wealth in regions with active land and property markets, suggesting that women are sharing in the ownership of assets purchased in the course of their lifetimes. In contrast, in regions where much of the wealth stock is comprised of ancestral land, women remain a smaller share of inheritance-leavers.
Divine Purpose? Religion, Race, and Attitudes Toward Life Extension Technology
Authors: Frost Jacqui , Schneider Rachel C , Henderson Andrea K , Ecklund Elaine Howard 
Published: September 2024

Abstract
There is a growing sociological literature examining how religion shapes attitudes toward science and technology. However, sociologists have done little to explore how attitudes toward religion and science shape support for end-of-life and life extension technologies. Past research suggests that those most likely to be interested in life extension technologies are nonreligious and White. However, we draw on theories in sociology of religion to examine how race and religion might intersect to shape attitudes about life extension. We find that Black Americans are significantly more interested in life extension than White Americans, and while religiosity decreases interest in life extension among White Americans, religiosity increases interest for Black Americans. And we find that Black and Hispanic Americans are more likely than White Americans to cite other-oriented and religious reasons over self-oriented reasons for wanting to extend their lives, such as “divine purpose” and a desire to contribute more to society.
Efficacy and Safety of Low-Fluence 730-nm Picosecond Laser in the Treatment of Melasma in Chinese Patients
Authors: Han Rui , Sun Yifang , Su Mingshan 
Published: September 2024

BACKGROUND
The 730-nm picosecond laser has shown promise in treating various benign pigmentary conditions, and it is yet to be determined whether it is effective and safe for melasma.

OBJECTIVE
The aim of this study was to investigate the potential benefits and risks of using the 730-nm picosecond laser to remove melasma.

MATERIALS AND METHODS
This is a retrospective review of all patients who presented to the clinic between April 2021 and April 2022 for the treatment of melasma with 730-nm picosecond laser alone. The efficacy of the laser was assessed based on the Melasma Area and Severity Index (MASI) score using high-resolution photographs evaluated by blinded dermatologists.

RESULTS
A total of 25 Chinese with Fitzpatrick skin Type II to IV were included. Patients were treated for an average of 3.56 ± 0.77 treatment sessions. The mean MASI scores decreased by 33.7% from 11.38 ± 6.60 to 7.55 ± 6.08 at an average of 8.48 ± 2.16 weeks of follow-up (p < .001). Among the patients, 1 experienced a 79% decrease, 6 had a decrease ranging from 51% to 75%, 10 had a decrease ranging from 26% to 50%, 5 had a decrease of less than 25%, and 3 experienced no changes in MASI scores. No hyper/hypopigmentation was observed.

CONCLUSION
Low-fluence 730-nm picosecond laser is an effective and safe modality for the treatment of melasma in Chinese patients.
Implant-based Breast Reconstruction Salvage with Negative Pressure Wound Therapy with Instillation: An Evaluation of Outcomes
Authors: Ahmed Shahnur , Hulsman Luci , Imeokparia Folasade , Ludwig Kandice , Fisher Carla , Bamba Ravinder , Danforth Rachel , VonDerHaar R. Jason , Lester Mary E. , Hassanein Aladdin H. 
Published: September 2024

Background:
Implant infection is problematic in breast reconstruction. Traditionally, infected tissue expanders (TE)/implants are removed for several months before replacement, resulting in breast reconstruction delay. Salvage involving device removal, negative pressure wound therapy with instillation and dwell (NPWTi-d) placement, and early staged TE/implant replacement within a few days has been described. The purpose of this study was to compare outcomes of the NPWTi-d salvage pathway with traditional implant removal.

Methods:
A retrospective review was performed on patients who underwent implant-based reconstruction and developed TE/implant infection/exposure requiring removal. Patients were divided into two groups. Group 1 had TE/implant removal, NPWTi-d placement, and TE/implant replacement 1–4 days later. Group 2 (control) underwent standard TE/implant removal and no NPWTi-d. Reinfection after TE/implant salvage, TE/implant-free days, and time to final reconstruction were assessed.

Results:
The study included 47 patients (76 TE/implants) in group 1 (13 patients, 16 TE/implants) and group 2 (34 patients, 60 TE/implants). The success rate (no surgical-site infection within 90 days) of implant salvage was 81.3% in group 1. No group 1 patients abandoned completing reconstruction after TE/implant loss versus 38.2% (13 of 34) in group 2 (P = 0.0094). Mean implant-free days was 2.5 ± 1.2 in group 1 versus 134.6 ± 78.5 in group 2 (P = 0.0001). The interval to final implant-based reconstruction was 69.0 ± 69.7 days in group 1 versus 225.6 ± 93.6 days in group 2 (P = 0.0001).

Conclusions:
A breast implant salvage pathway with infected device removal, NPWTi-d placement, and early TE/implant replacement was successful in 81.3%. Patients experienced 132 less implant-free days and faster time to final reconstruction.
The Influence of Treatment With Sofosbuvir/Velpatasvir on Children’s Growth—Results of the PANDAA-PED Study
Authors: Pokorska-Śpiewak Maria , Talarek Ewa , Aniszewska Małgorzata , Pluta Magdalena , Dobrzeniecka Anna , Marczyńska Magdalena , Indolfi Giuseppe 
Published: September 2024

Background:
The aim of this study was to evaluate the influence of treatment of hepatitis C with sofosbuvir and velpatasvir (SOF/VEL) on children’s growth.

Methods:
Fifty children 6-18 years of age were successfully treated for hepatitis C with a 12-week course of SOF/VEL fixed dose adjusted to the body weight in the PANDAA-PED (Treatment of chronic hepatitis C in children 6–18 years of age using a pangenotypic direct-acting antiviral sofosbuvir/velpatasvir) project. Growth parameters were compared at 1 year after treatment with baseline (at the start of treatment) and 12-week-posttreatment values. Body mass index (BMI), weight and height Z scores adjusted to sex and age were calculated according to the World Health Organization reference data.

Results:
Forty-nine participants (23 boys and 26 girls) completed all the visits. The mean age at 1 year after treatment was 10.9 ± 2.5 years, and all children had undetectable hepatitis C virus RNA at this point. Significant weight and height gains were observed after treatment irrespective of the patients’ age and sex. Height Z scores did not vary significantly both at 12 weeks and 1 year after treatment, confirming a normal increase in participants’ height. Weight Z scores for 16 children below 10 years of age decreased at 1 year after treatment. BMI Z score values decreased at 12 weeks after treatment compared to the baseline in boys, but no difference was found between 1-year posttreatment and baseline BMI Z scores in both girls and boys.

Conclusions:
Results of the PANDAA-PED study showed normal growth up to 1 year after successful treatment with SOF/VEL in children 6-18 years of age. Despite the decrease in BMI Z score in boys observed at 12 weeks after treatment, no differences were found between baseline and 1-year posttreatment values. Our observations confirm the long-term safety of the SOF/VEL treatment in children 6-18 years of age.
Stenotrophomonas maltophilia Associated Factors and Outcomes in a Neonatal Intensive Care Unit: A Retrospective Matched Case-control Study
Authors: Franco Susannah , Abdelhemid Ashraf , Fordjour Lawrence , Kohlhoff Stephan , Hammerschlag Margaret R. 
Published: September 2024

Background:

Stenotrophomonas maltophilia is a multi-drug-resistant, hospital-acquired Gram-negative bacillus associated with significant morbidity and mortality. The objective of this study is to identify risk factors and outcomes associated with S. maltophilia isolation in a high-risk neonatal population.

Methods:
This was a retrospective matched case-control study. Cases were matched 1:2 for years of neonatal intensive care unit admission, completed weeks’ gestational age and birth weight in 250-gram incremental categories.

Results:
A total of 15 cases and 35 controls were included in the analyses. Risk factors for S. maltophilia isolation included days of antibiotics (24 vs. 18, P = 0.036), days of broad-spectrum antibiotics (19 vs. 12 days, P = 0.027), days of meropenem (9 vs. 6 days, P = 0.018) and any meropenem exposure (100% vs. 22%, P = 0.005). Other risk factors were any corticosteroid exposure (66.7% vs. 20%, P = 0.001), days of total parenteral nutrition (55 vs. 31 days, P = 0.017) and days of invasive mechanical ventilation (28 vs. 7, P = 0.015). S. maltophilia isolation was associated with increased length of neonatal intensive care unit stay (134 vs. 69 days, P < 0.001) and mortality (33.3% vs. 0%, P = 0.001).

Conclusions:
Antibiotic stewardship efforts should be made to decrease the risk of S. maltophilia isolation and associated mortality. Carbapenem over-use should be specifically addressed with institutional policies and unit-based guidelines. Additional neonatal studies are needed to confirm these findings and explore other possible risk factors.
Pediatric Clinical Outcomes of Nasal Methicillin-resistant Staphylococcus aureus Polymerase Chain Reaction Utilization
Authors: Demirhan Salih , Burgos Kevin , Escobar Lee Kiriam , Lee Philip , Sy Sharlene , Herold Betsy C. , Anosike Brenda I. 
Published: September 2024

Background:
Methicillin-resistant Staphylococcus aureus (MRSA) is a clinical challenge in selecting empiric antimicrobials for pediatric infections. We implemented nasal MRSA polymerase chain reaction (nMRSA PCR) screening as a diagnostic tool and evaluated its impact on empiric antibiotic use and clinical outcomes.

Methods:
A retrospective single-center study of patients hospitalized with infections who were empirically prescribed anti-MRSA antibiotics was conducted prior to and following the initiation of nMRSA PCR screening. Electronic medical records, pharmacy data and bacterial cultures results were reviewed. Predictive values of nMRSA PCR testing were calculated and the duration of anti-MRSA empiric therapy and clinical outcomes preimplementation and postimplementation were compared.

Results:
During the preimplementation period, there were 382 distinct episodes (294 unique patients) that met the inclusion criteria and during post-nMRSA PCR implementation, 394 episodes (360 unique patients) were identified. The median time to discontinuation of anti-MRSA antibiotics and proportion of patients prescribed anti-MRSA antibiotics at discharge were significantly lower in postimplementation compared with preimplementation period; 48 versus 56 hours, P < 0.001 and 20.1% versus 40.3%, P < 0.001, respectively. The negative and positive predictive values of nMRSA PCR compared to clinical culture results were 95.6% and 51.2%, respectively. Predefined adverse outcomes were documented in 11 patients who had early anti-MRSA discontinuation with negative nMRSA PCR results but only 3 were restarted on anti-MRSA treatment and none grew MRSA in clinical cultures.

Conclusions:
Shortened anti-MRSA antibiotic duration, high negative predictive value and low adverse events provide promising evidence that nMRSA PCR is an effective, rapid antimicrobial stewardship tool for hospitalized children.
Kiteboarding Injuries: Epidemiology, Common Treatment Strategies, and Time to Return to Kiteboarding Following Injury
Authors: Beer Yiftah , Yona Tzadok , Arama Yuval , Lindner Dror , Garrigues Grant , Feletti Francesco , Blond Lars , Gilat Ron 
Published: September 2024

Objective:
To evaluate the prevalence and types of injuries incurred during kiteboarding (1), along with treatment approaches (2). In addition, the time to return to kiteboarding following injury (3) and factors associated with the rate and type of injury were analyzed (4).

Setting:
Recreational kiteboarding.

Design:
Retrospective cohort.

Participants:
Three hundred twelve kiteboarders (280 men, 32 women, mean age 42.91 ± 13) were included in the study.

Independent Variables:
Age, sex, experience, and the use of protective gear.

Main Outcome Measures:
Kiteboarding experience, injury location, type, incidence, nonsurgical and surgical treatment modalities, and return-to-kiteboarding data.

Results:
The number of injuries calculated per 1000 sessions was a mean of 7.82 (4.83-10.81). Patients with less than 2 years of kiteboarding experience were at a greater risk of injury than more experienced kiters (P < 0.001). The knee (24.1%), ankle and foot (18.9%), ribs (12.7%), and shoulder (10.2%) were the body parts most frequently injured. Overall, 14.4% of kiters underwent surgical intervention, with knee surgery being the most common site of operation (41.9%) and the most frequently performed procedure being anterior cruciate ligament reconstruction.

Conclusions:
The pattern of reported injury was found to be different from that previously reported in the scientific literature among freeriding kiters, with knees, ribs, and shoulders being most frequently involved. Participants with <2 years of experience had a significantly greater risk of injury; therefore, proper technical and physical training is advisable.
TASER 7 and TASER 10 Probe Penetration Into Human Skull Simulants
Authors: Khmara Natalia , Gort Silvan , Kaelin Beat , Thali Michael J. , Bolliger Stephan A. 
Published: September 2024

Abstract
The older generation TASER probes X26 and X2 have been shown to be capable of piercing the skull with their tips. With the introduction of the new TASER 7 and the far more powerful TASER 10, concerns have arisen as to whether these weapons might penetrate the skull more deeply and thus prove to be potentially lethal. For this reason, we tested the penetration capacity of these weapons on polyurethane-gelatine-buckskin head simulants at different firing distances. The striking speeds and striking angles were documented with a high-speed camera, and the piercing depths were recorded by computed tomography. None of the probes penetrated the skull, but their tips did; TASER 7 probe tips pierced up to 5.6 mm, whereas TASER 10 probe tips pierced up to 10.4 mm. The TASER 7 probes fared better with regard to penetration depth at shorter firing distances; on the other hand, the TASER 10 probes pierced more deeply at distances of 3 to 4 m, with their flight stability improving after the first 2 m. Our results imply that TASER 7 and TASER 10 probes are not to be expected to cause great harm or even death when striking the head.
Reconstructing Failure: Assessing Surgical and Patient Reported Outcomes Following Loss of Initial Breast Reconstruction
Authors: Kim Minji , Khavanin Nima , Jiang Charles Z. , Barnett Joshua M. , Boe Lillian A. , Allen Robert J. , Stern Carrie S. , Mehrara Babak J. , Nelson Jonas A. 
Published: September 2024

Background:
Breast reconstruction failure, defined as the removal of a prosthetic device or flap without immediate replacement, can be traumatic for patients. We aim to describe the progression of patients who experience tissue expander (TE), implant, or autologous breast reconstructive failure and assess the patient reported outcomes (PROs) among patients who undergo additional reconstruction.

Method:
Patients undergoing TE, implant, or autologous breast reconstruction between 2017 and 2022 were included, and patients with reconstructive failures were identified. Outcomes of interests included (1) receipt of additional reconstruction and (2) BREAST-Q scores 1-year after reconstructive failure. We also performed a propensity-matched analysis between patients who undergo secondary reconstruction and patients who had an uncomplicated reconstruction.

Results:
4,258 TE, 4,420 implant, and 1,545 autologous breast reconstruction patients were included. Of patients who experienced reconstructive failures, 49.5% of TE, 4.8% of implant, and 53.8% of autologous patients underwent secondary reconstruction. Age, psychiatric diagnosis, chemotherapy, radiation, and mastectomy type were associated with increased likelihood of secondary reconstruction. Between patients with and without additional reconstruction, higher Psychosocial Well-being trended towards the former cohort (61 [Interquartile Range: 56, 80] vs 50 [46, 65], p=0.085). Propensity-matched analysis demonstrated comparable PROs at 1-year after definite reconstruction.

Conclusion:
Less than half of reconstructive failure patients undergo an additional reconstruction. Patients with secondary reconstruction may have improved Psychosocial Well-being than those who do not and comparable PROs to those who had uncomplicated initial reconstruction. Surgeons should counsel patients with reconstructive failures that although traumatizing, secondary reconstruction may be beneficial.