bluuebunny/crossref_metadata_2025_split huggingface dataset:
PSICOPATAS NO MUNDO CORPORATIVO: UM ESTUDO SOBRE AS CARACTERÍSTICAS E CONSEQUÊNCIAS DE SUA PRESENÇA NO AMBIENTE DE TRABALHO
Authors: Cesar Ingrid Ramos de Morais , Lopes Rubens Fernando de Souza 
Published: October 2024

Objetivo: O objetivo deste estudo é investigar o impacto da psicopatia corporativa no clima organizacional, a partir da perspectiva psicanalítica, buscando identificar as dinâmicas relacionais e os mecanismos de defesa utilizados por esses indivíduos.

Referencial Teórico: O referencial teórico baseia-se em conceitos psicanalíticos sobre a personalidade, como o modelo estrutural de Freud e os mecanismos de defesa, além de teorias sobre liderança e comportamento organizacional. Essas teorias permitem compreender as raízes da psicopatia e suas manifestações no ambiente de trabalho.

Método: Para coletar os dados necessários, foram utilizadas as técnicas de pesquisa documental e bibliográfica. Essa combinação permitiu uma análise detalhada de documentos e textos relevantes, proporcionando uma base sólida para a compreensão do fenômeno estudado.

Resultados e Discussão: A presença de líderes com traços psicopáticos tem um impacto devastador no clima organizacional, afetando tanto os funcionários quanto a performance da empresa.

Implicações da Pesquisa: As implicações desta pesquisa podem auxiliar na elaboração de programas de treinamento para gestores, visando à identificação e o manejo de comportamentos psicopáticos. Além disso, os resultados podem contribuir para o desenvolvimento de ferramentas de avaliação de clima organizacional que detectem sinais de disfunções relacionais.

Originalidade/Valor: Este estudo contribui para a literatura ao aprofundar a compreensão das dinâmicas psicológicas envolvidas na psicopatia corporativa, especialmente no contexto brasileiro. Ao utilizar uma abordagem qualitativa e focar nas experiências dos funcionários, a pesquisa oferece uma perspectiva única sobre as consequências desse fenômeno para o bem-estar individual e organizacional.
EVALUATION OF INTERNET ACCESS BY STUDENTS AT A FEDERAL EDUCATIONAL INSTITUTION IN NORTHERN BRAZIL
Authors: Kristian Adris , Nascimento-e-Silva Daniel 
Published: October 2024

Objective: This study presents the results of assessing Internet access by students at a federal educational institution in northern Brazil.

Theoretical Framework: The study's theoretical framework relates information technologies through Internet access to learning. It shows that the more adequate Internet access is in educational institutions' daily routines, the better the students' performance in learning and its developments in technical, scientific, and technological production.

Method: The method used was a survey, the population of which consisted of students who attended classes during the three shifts during which the institution operated. The students were consulted through a questionnaire with multiple-choice questions, the results of which were generated using descriptive statistics and presented in frequency tables.

Results and Discussion: The findings showed deficiencies in a) the connection attributes, b) insufficient connection about the types of use by students, c) the connection provided is of low quality, and d) there is excess demand about the low institutional supply, especially in the evening shift.

Research Implications: This study shows that internet services must be the object of multidisciplinary treatment and cannot represent the exclusive view of ICT professionals or education specialists. Unidisciplinary views prevent several fundamental nuances of institutional core activities from being overlooked.

Originality/Value: The research's originality lies in the empirical observation that educational institutions must strategically plan long-term internet provision jointly by ICT professionals, education specialists, teachers, and students.
Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019
Authors: Guerrero-Vadillo María , Peñuelas Marina , Carmona Rocío , León-Gómez Inmaculada , Varela Carmen 
Published: October 2024

Background
Hepatitis E, a viral hepatitis caused mainly by the ingestion of raw or undercooked food, is not a notifiable disease in Spain.

Aim
To analyse the temporal trends, epidemiological characteristics and factors associated with severe disease from hepatitis E hospitalisations in Spain from 1997 to 2019.

Methods
Hospitalisation records were obtained from the Spanish National Hospital Discharge Database. Temporal trends and seasonality were analysed by Poisson regression in years 1997–2015 and 2016–19, given changes in hospital discharge databases. Multivariate logistic regression was used to identify factors associated with severe disease.

Results
Hepatitis E hospitalisation incidence increased from 0.22 cases per 1,000,000 inhabitants in 1997 to a maximum of 2.95 in 2018. Seasonality was observed during 2016–19 period, with more cases in the second and third quarters of the year. The incidence was higher in men vs women, and in the population aged over 40 years. Factors independently associated with death were age ≥ 50 years (adjusted odds ratio (aOR): 2.43), chronic liver disease (aOR: 4.29), HIV infection (aOR: 3.00) and hepatitis B/C (aOR: 2.11).

Conclusions
Hepatitis E hospitalisations have increased in Spain in recent years, being more severe in cases with older age, chronic hepatic diseases and HIV infection. A greater incidence in men over 40 years and a possible seasonality were observed. Further studies are needed to assess the seasonality, geographical distribution and impact of the disease to guide public health actions for prevention and control.
Pelatihan Pengembangan LKPD Berbasis Discovery Learning Berbantuan Virtual Reality
Authors: Rahmawati Laifa , Widodo Setiyo Wibowo  , Sabar Nurohman  , Feby Permata Sari  
Published: October 2024

Perkembangan ilmu pengetahuan dan teknologi memberikan kontribusi dalam meningkatkan kemajuan di berbagai bidang khususnya pendidikan. Kegiatan ini merupakan pelatihan pengembangan LKPD IPA berbasis Discovery learning berbatuan Virtual Reality untuk mendukung revolusi industri 5.0 yang berguna dalam perkembangan IPTEK berbentuk media pembelajaran di sekolah. Kegiatan ini mendukung capaian pemahaman dan skenario HOTS. Kegiatan pelatihan ini dilakukan dengan 29 guru IPA SMP di Kabupaten Sleman dan Kota Yogyakarta Propinsi Daerah Istimewa Yogyakarta. Kegiatan dilaksanakan meliputi pemetaan kebutuhan guru, pengenalan MileaLab, perancangan dan pemilihan topik pembelajaran IPA pada MileaLab yang dikembangkan menjadi LKPD IPA berbasis Discovery learning berbantuan Virtual Reality beserta evaluasinya. Kegiatan ini dilaksanakan di Ruang sidang III lantai 1 FMIPA UNY. Tahapan kegiatan ini meliputi persiapan, pelaksanaan, dan evaluasi. Pada tahap pelaksanaan dilakukan dengan berbagai metode seperti workshop serta demontrasi dan praktik terbimbing. Teknik pengumpulan data melalui angket Skala Guttman terkait pengetahuan awal dan persepsi guru terhadap virtual reality. Berdasarkan kegiatan yang telah dilakukan, diperoleh hasil bahwa guru-guru yang mengikuti pelatihan mampu membuat perancangan dan pemilihan topik pada Millealab yang akan dikembangkan menjadi LKPD berbasis Discovery learning berbantuan virtual reality
Exploring the Role of Public and Private Partnerships in Educational Development of Nepal
Authors: Singh Renu 
Published: October 2024

The education system of Nepal has undergone significant transformation in the last few decades. The transition is observed from a primarily government-driven model to one that increasingly incorporates public-private partnerships (PPPs). This paper aims to explore the role of these partnerships in enhancing educational quality, access, and equity in Nepal. By examining case studies, policy frameworks, and outcomes of various initiatives, it is assessed the efficacy of PPPs in addressing the systemic challenges faced by the Nepali education sector. The research also provides critical insights into how these partnerships can be leveraged to achieve Sustainable Development Goal (SDG) 4: Quality Education. Additionally, this paper also explores the role of PPPs in enhancing Nepal's educational development by improving infrastructure, access to education, teacher training, and overall quality of education. Through a review of existing literature and case studies, this study assesses the effectiveness, challenges, and potential of PPPs in transforming educational landscape of Nepal.
Int. J. Soc. Sc. Manage. Vol. 11, Issue-4: 136-140.
Profile of Medico-legal Age Estimation Cases in a Tertiary Hospital in Kathmandu
Authors: Chaudhary Gopal Kumar , Shrestha Sabnam , Dahal Samarika , Maharjan Mani Raj , Walung Eugen Dolma , Kadel Tulsi , N Srikant 
Published: October 2024

Introduction: Medico-legal age estimation is the estimation of chronological age of an individual which is based upon analysis of physical development of the body, development of secondary sexual traits, tooth eruption, appearance of ossification centers of bones, and the degree of epiphyseal union. Chronological age of the subject whether a minor (less than 18 years) or an adult determines the fate of the case in the court of law.
Objective: The present study revealed varied profiles of the perpetrator and the victim who came for medico-legal age estimation.
Methods: This is a retrospective, descriptive cross-sectional study conducted in the Department of Forensic Medicine, Maharajgunj Medical Campus, Institute of Medicine (IoM). The data of medico-legal age estimation of 5 years period was analyzed using the statistical software SPSS 20.
Results: Total of 313 individuals were studied. Majority of the individuals were within the age group of 16-17 years. Males (70.3 %) outnumbered females (29.7 %). Theft (31.9 %) was common among subjects, followed by sexual assault (18.2 %) and majority of subjects (59.7%) came from Province 3. Sixty percent of the subject’s alleged age, matched the estimated ages.
Conclusion: This study shows the status of children in crime which demands attention of concerned authority. Males were significantly involved in theft and females were victims of sexual assault. Forty percent of the alleged age given by the subject differed from the estimated age, to change the fate of the case. These results could greatly benefit the judiciary system of Nepal.
Comparison of Intrathecal Hyperbaric Bupivacaine Alone and Hyperbaric Bupivacaine with Fentanyl in Lower Limb Surgery
Authors: Ghimire Basanta , Khanal Kishor , Ghimire Kundan Kishor , Bajracharya Anurag 
Published: October 2024

Introduction: Subarachnoid block is the preferred anaesthetic technique used for lower limb surgeries because of its rapid and profound sensory and motor blockade. Opioids are widely used in conjunction with local anaesthetics in neuraxial blocks for their property of improving the quality and prolonging the duration of local anaesthetics for surgical anaesthesia, as well as post-operative analgesia.
Objectives: Objective of this study was to compare the duration of two segment regression, motor blockade and sensory analgesia, with intrathecal hyperbaric Bupivacaine alone and with Fentanyl added.
Method: In this study, 80 patients above 15 years with ASA (American Society of Anaesthesiologist) physical status I and II, undergoing subarachnoid block for various lower limb surgeries were studied in a double-blinded, randomized prospective manner. Patients were divided into two equal groups - Group B (n= 40) received hyperbaric bupivacaine 15 mcg, and Group BF received hyperbaric bupivacaine 12.5 mg with fentanyl 25 mcg, making a total volume of 3 ml in both the groups. Patients were compared intraoperatively and postoperatively for the duration of motor blockade, time for two segment regression and duration of sensory analgesia and complications.
Results: The time for two segment regressions, time for sensory analgesia, duration of motor blockade, was significantly higher in group BF i.e., 119 ±19 mins, 310 ±20 mins and 236±17 mins respectively, as compared to group B i.e., 83 ±20, 223 ± 22, 186 ±19 minutes respectively. Both the groups were comparable with demographic profile and hemodynamic parameters.
Conclusion: The addition of fentanyl 25 mcg prolongs the time for two segment regression and duration of sensory analgesia for lower limb surgeries.
Assessment of CD40L and TSAB serum level in Graves disease patients
Authors: Jawad Alkhansaa Tariq , Fahad Hayfaa Mahmood , Salih Ayat Ali 
Published: October 2024

BACKGROUND: The autoimmune disorder known as Graves’ disease. The condition is due to the binding of thyroid-stimulating immunoglobulins to the thyrotropin receptor located on the thyroid gland. The result is an excess of thyroidal hormones. symptoms of hyperthyroidism, and the formation of diffuse goiter. OBJECTIVES: This research intends to quantify the levels of CD40L, TSAB in people who suffer from Graves’ disease. It also aims to determine the relationship between TSAB and the duration of the disease, as well as analyze the role of CD40L as a predictive marker for Graves’ disease using medcalc Statistical Software version 16.4.3 and SAS (2018). METHODS: In a case-control study, randomly selected 90 graves disease patients were included, the randomly selected patients were divided equally and matched into a case group who have graves disease and graves disease-free patients as a control group. For both groups whole blood sample was examined to compare for (TSAB), and (CD40L) levels determination by ELISA technique. RESULTS: The average serum levels of CD40L showed a highly significant correlation (P value < 0.01) among the groups examined for Graves’ disease. The patient group consisted of 13 males (28.89%) and 32 females (71.11%). No significant correlation was identified between TSAB and the duration of the condition. CONCLUSION: Thyroid stimulating antibody (TSAb) test and ultrasonography of the thyroid gland are valuable diagnostic techniques for autoimmune Graves’ disease (GD). CD40L could potentially serve as a predictive diagnostic marker for Graves’ disease. However, there is no observed link between the duration of the disease and the concentration of TSAB.
Coping Self-Efficacy and Stress Mindset as Predictors of Student Success Outcomes
Authors: Kapil Meg , Rostampour Ramin , Hadwin Allyson 
Published: October 2024

University students experience stress from academic demands. Stress is in fact expected in academic settings and important for achieving goals. How students experience the inevitable stress in the academic context, and whether stress is a support or hindrance for them, is related to their beliefs about stress. This study examined two types of beliefs regarding academic stress: (a) perceptions of being capable of coping with academic stress and demands, named coping self-efficacy, and (b) general beliefs regarding stress itself, named stress mindset, and the impact of those two stress beliefs on two types of outcomes related to student success: academic performance (GPA) and student experiences (mental health, perceived motivation challenges). Findings indicate coping self-efficacy positively predicts higher mental health and lower motivation challenges; neither stress mindset nor coping self-efficacy predicted GPA. Coping self-efficacy in the university context, which denotes feeling capable of managing stress and academic demands, emerged as a useful predictor of student success outcomes. As eliminating stress altogether is not practical or possible, this research focuses on beliefs about stress as important for student success.
Predicting the microalgae lipid profile obtained by supercritical fluid extraction using a machine learning model
Authors: Rangel Pinto Juan David , Guerrero Jose L. , Rivera Lorena , Parada-Pinilla María Paula , Cala Mónica P. , López Gina , González Barrios Andrés Fernando 
Published: October 2024

In this study a Machine Learning model was employed to predict the lipid profile from supercritical fluid extraction (SFE) of microalgae Galdieria sp. USBA-GBX-832 under different temperature (40, 50, 60°C), pressure (150, 250 bar), and ethanol flow (0.6, 0.9 mL min-1) conditions. Six machine learning regression models were trained using 33 independent variables: 29 from RD-Kit molecular descriptors, three from the extraction conditions, and the infinite dilution activity coefficient (IDAC). The lipidomic characterization analysis identified 139 features, annotating 89 lipids used as the entries of the model, primarily glycerophospholipids and glycerolipids. It was proposed a methodology for selecting the representative lipids from the lipidomic analysis using an unsupervised learning method, these results were compared with Tanimoto scores and IDAC calculations using COSMO-SAC-HB2 model. The models based on decision trees, particularly XGBoost, outperformed others (RMSE: 0.035, 0.095, 0.065 and coefficient of determination (R2): 0.971, 0.933, 0.946 for train, test and experimental validation, respectively), accurately predicting lipid profiles for unseen conditions. Machine Learning methods provide a cost-effective way to optimize SFE conditions and are applicable to other biological samples.
Systematic identification of therapeutic targets for coronary artery calcification: an integrated transcriptomic and proteomic Mendelian randomization
Authors: Chen Lihong , Ye Xiaoqi , Li Yan , Ran Xingwu 
Published: October 2024

BackgroundCoronary artery calcification (CAC) is associated with an increased risk of mortality and cardiovascular events. However, none therapeutic drugs have been proven effective for CAC treatment. The objective of this study was to identify potential therapeutic targets for CAC through the utilization of Mendelian randomization (MR) and colocalization analysis.MethodsThe expression quantitative trait loci (eQTLs) of 16,943 genes from the eQTLGen consortium and protein quantitative trait loci (pQTLs) of 4,412 proteins from a plasma proteome were utilized as genetic instruments. Genetic associations with CAC were derived from a GWAS meta-analysis of 26,909 individuals. The MR and colocalization analysis were utilized to identify potential target genes.ResultsA total of 671 genes were found to be significantly associated with the risk of CAC based on transcriptomic MR analysis at a false discovery rate &lt;0.05, while proteomic MR analysis identified 15 genes with significant associations with CAC at the same threshold. With robust evidence from colocalization analysis, we observed positive associations between CWF19L2, JARID2, and MANBA and the risk of CAC, while KLB exhibited an inverse association. In summary, our study identified 23 potential therapeutic targets for CAC. Further downstream analysis revealed IGFBP3, ABCC6, ULK3, DOT1L, KLB and AMH as promising candidates for repurposing in the treatment of CAC.ConclusionThe integrated MR analysis of transcriptomic and proteomic data identified multiple potential drug targets for the treatment of CAC. ULK3, DOT1L, and AMH were recognized as novel targets for drug repurposing for CAC and deserve further investigation.
A qualitative study illustrating factors that enable and constrain academic advising practices in a Global South context
Authors: Versfeld Jessica , Mapaling Curwyn 
Published: October 2024

IntroductionAcademic advising plays a crucial role in South African higher education, especially considering the country’s diverse student population, historical injustices, and socio-economic inequalities. However, there is a lack of research supporting academic advising practices in this context.MethodsThis study employs a qualitative methodology, using semi-structured in-depth interviews with four academic advisors from the Engineering, Built Environment, and Information Technology (EBIT) department at a South African university. A socio-ecological lens is applied to explore the factors enabling and constraining best practices in academic advising.ResultsKey findings reveal that academic advisors face challenges such as limited resources and institutional support. However, opportunities exist for fostering student resilience and academic success. The study identifies enablers and constraints across microsystemic (e.g., advisor passion and resilience), mesosystemic (e.g., interdepartmental collaboration), and macrosystemic (e.g., institutional policies, socio-economic factors) levels.DiscussionAs part of the Global South, South Africa shares many socio-economic and educational challenges with other countries in the region. The study’s findings offer insights that may be relevant to similar contexts. By illuminating the mechanisms that empower the academic advising community, this research seeks to inform the development of more effective student support interventions. The socio-ecological framework provides a comprehensive understanding of the interconnected influences contributing to the efficacy and challenges faced by academic advisors in engineering departments.
Association between hypothyroidism and metabolic syndrome in Qinghai, China
Authors: Fan Xiaoxia , Yao Yongli , Chai Shengjun , Wang Beibei , Xie Yanling , Jiang Yanping , Lin Lijun , Li Yanan , Fan Peiyun , Luo Wei , Wang Shuqiong , Song Kang , Zhao Lingling , Cai Chunmei 
Published: October 2024

ObjectiveTo investigate the epidemiological characteristics of hypothyroidism in Qinghai Province, analyze its related influencing factors, establish the normal reference range of thyroid function, and explore the relationship between thyroid hormone (THs), thyroid stimulating hormone (TSH) and metabolic syndrome (MS) in Qinghai population within the normal range, so as to provide some scientific basis for the prevention and treatment of hypothyroidism in Qinghai Province.MethodsA total of 2790 residents aged 18 and over from Qinghai were selected through stratified cluster random sampling. Data were collected via questionnaires, physical examinations, and laboratory tests.Results1. A total of 2628 eligible residents in Qinghai were included in this study, and the total prevalence of hypothyroidism was 30.25%, among which the prevalence of subclinical hypothyroidism was 29.22%, and the prevalence of clinical hypothyroidism was 1.03%. 2. The prevalence of hypothyroidism in women was significantly higher than that in men (36.69% vs 24.30%); smoking and drinking were risk factors for hypothyroidism. 3. In the excluded subjects, 1544 were abnormal thyroid ultrasound, abnormal thyroid function and/or positive thyroid autoantibodies, and the remaining 1084 were reference populations. According to the reference population data, the 95% reference ranges of TSH, FT4, FT3 were 0.43-5.51 mIU/L, 11.0-20.4 pmol/L, 3.63-5.73 pmol/L, respectively. 4. In the normal thyroid function population in Qinghai, MS and its related components were positively correlated with FT3 and FT4 levels, but not significantly correlated with TSH levels.Conclusion1. The prevalence of hypothyroidism in adults in Qinghai is relatively high, accounting for about one-thirtieth of the total population. Smoking and drinking have a certain impact on the incidence of hypothyroidism. 2. It provides a reference range for the diagnosis of thyroid diseases in Qinghai province, which is different from that of reagent suppliers, and has certain promotion significance in the western region. 3. MS and its related components are positively correlated with FT3 and FT4 levels, but not with TSH levels in people with normal thyroid function in Qinghai. Early thyroid function screening is of great significance for the prevention of MS.