bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningkatkan Pemahaman Konsep Pernikahan dalam Pandangan "Fiqih Munakahat" pada Pemuda Pemudi di Desa Sidomulyo
Authors: Aisa Aufia , Hidayah Nurul , Putra Wahyu Hanafi , Irfan M. Ali , Husniah Ludfiah Novi Cahyanii , Fajariyah Linda 
Published: September 2024

Masyarakat desa Sidomulyo memiliki kegiatan keagamaan secara rutin. Oleh karena itu, para warga sekitar melaksanakan kegiatan keagamaan seperti pembacaan yasin dan tahlil, pembacaan dibaâ€™, istighotsah, dan lainnya untuk memperkuat keimanan mereka terhadap Allah SWT. Berdasarkan hasil observasi yang dilakukan melalui kegiatan keagamaan di desa Sidomulyo di temukan permasalahan yang menjadikan ketertarikan untuk mengadakan suatu kajian bagi para pemuda-pemudi di desa tersebut, ternyata mayoritas pemuda/pemudi di desa tersebut masih belum menikah. Menurut data yang di peroleh terdapat 200 pemuda/pemudi Sidomulyo yang belum menikah dengan jenjang usia 25-40 tahun. Salah satu alasan yang diperoleh adalah kebanyakan pemuda pemudi di desa Sidomulyo lebih mengedepankan karir daripada menikah dan juga kurangnya pemahaman tentang fiqih munakahat pada masyarakat Sidomulyo terutama pada rukun dan syarat menikah. Tujuan dari pengabdian ini untuk memberikan pembinaan dan pembekalan tentang meningkatkan pemahaman pemuda/pemudi tentang konsep nikah. Sasaran utama kegiatan ini yaitu14 orang remaja masjid yang ada di dsn Dempok dan IPNU IPPNU dusun Dempok desa Sidomulyo. Adapun metode atau pendekatan yang dapat digunakan diantaranya adalah metodologi pengabdian masyarakat yang dianggap relevan seperti Service Learning (SL). Evaluasi dilakukan sebelum dan sesudah kajian pernikahan. Kriteria mulai jumlah peserta yang mengikuti kajian, pemahaman peserta terhadap materi yang dikaji dan indikator pencapaian dari kajian pernikahan adalah peserta memahami konsep pernikahan perspektif fiqih dan tolak ukur yang digunakan untuk menyatakan keberhasilan dari kegiatan pengabdian yang dilakukan peserta dibagikan angket. Hasil dari angket respon peserta kajian ini diperoleh dari 14 peserta kajian. Hasil presentase rata-rata angket respon peserta kajian sebesar 77.71% dengan kategori baik.
Trabajo de campo en un contexto transnacional: Entre Seúl y la Ciudad de México
Authors: Contreras Aragón Dinorah Lizeth 
Published: September 2024

El texto que a continuación se presenta busca mostrar las implicaciones del trabajo de campo en un contexto transnacional para los estudiantes de antropología neófitos en la aplicación del método etnográfico. Haciendo uso del concepto de viaje, la autora relata desde su propia experiencia las dificultades que surgen de aquello que los antropólogos definen como observación participante.
cultura festiva de la política: La jura real de Fernando VI en tres ciudades coloniales (Durango, Puebla y Mérida)
Authors: Flores Sosa Emmanuel Mitchel 
Published: September 2024

El presente artículo ofrece un estudio comparativo de las fiestas públicas celebradas en tres ciudades de la Nueva España, entre los años de 1747 y 1748, con el objeto de celebrar el ascenso de Fernando VI como nuevo rey de la monarquía hispánica. En esta comparación, se toma en consideración el papel de los grupos indios que participaron en las conmemoraciones reales, las particularidades sociopolíticas que imperaban en cada uno de los asentamientos urbanos y cómo éstas influyeron en las estructuras protocolarias de dichas celebraciones.
Xantolo en la huasteca hidalguense: reflejos de los nahuas en Yahualica
Authors: Morales Garcia Jonatan Job , Morales Garcia Angel Daen 
Published: September 2024

El presente trabajo tiene como objetivo mostrar el tradicional Xantolo (festividad de todos los santos), también llamado de manera popular como fiesta de los muertos, a través de registros fotográficos realizados en el municipio de Yahualica, estado de Hidalgo del 26 de octubre al 2 de noviembre del año 2016. La celebración del Xantolo es un fenómeno social cargado de significados y elementos culturales asociados a la herencia cultural huasteca y nahua, esta festividadactualmente tiene una especial relación con los pueblos y comunidades indígenas asentados en esta región y tiene una importante función que propicia la cohesión social y fortalece la identidad cultural huasteca.
Archivos y Bibliotecas en México, un devenir de siglos y azares
Authors: Canto Alcocer Jorge Alberto 
Published: September 2024

El presente dossier, titulado “Archivos y Bibliotecas en México, un devenir de siglos y azares”, examina la praxis y desarrollo de estas instituciones, fundamentales para la realización de investigaciones científicas y depositarias de bienes patrimoniales de gran significado cultural y social, pero que hasta el momento han recibido escasa atención en los estudios académicos. Se integra por tres artículos que analizan, desde diversas perspectivas, como se han construido estos espacios, considerando tanto las acciones individuales como los procesos institucionales para brindarnos una visión múltiple e integral sobre este tema poco conocido fuera del ámbito de los especialistas.
Masculinidades disidentes
Authors: Hernández Galván Francisco , Vargas Silva Alethia Dánae 
Published: September 2024

El objetivo principal de esta investigación es mostrar la complejidad que existe en la construcción de masculinidades disidentes con varones no-heterosexuales de las localidades de Guadalajara, Jalisco y Ciudad Hidalgo, Michoacán, cuyo trabajo etnográfico tuvo lugar en un periodo entre 2014 y 2016. Se trata de una metodología mixta que utiliza las redes semánticas a la vez que recupera entrevistas en profundidad. El enfoque que se utilizó fue una perspectiva feminista-queer que pone en tensión las categorías analíticas performatividad de género y masculinidades disidentes, por lo que enfatizamos la necesidad de entender esta yuxtaposición como un proceso complejo y dinámico. Como resultado de investigación encontramos que coexisten y proliferan diversas prácticas discursivas que subjetivan y se enraízan en la constitución y reconocimiento de la «masculinidad» de los sujetos que la practican.
Así empezó todo. Orígenes del neoliberalismo
Authors: Díaz Itzel Rubi 
Published: September 2024

La presente reseña tiene como objetivo destacar la interesante labor del Dr. Escalante Gonzalbo, quién, atendiendo a la urgente necesidad de vislumbrar de manera histórica y concisa, el origen de la corriente teórica e ideológica neoliberal, se dio a la tarea de traducir las actas del Coloquio Lippmann al Español. Lo que renueva la pertinencia de los estudios sobre historia del pensamiento económico. De manera que el presente trabajo, señala algunos de los temas tratados y discusiones que lograron transformarse en el modelo económico actual, característico en gran parte del mundo.
La feria de semillas regresa, Chacsinkín 2002-2022
Authors: Rosales González Margarita , Benavides Rosales Gabriel 
Published: September 2024

Se expone con fotografías y un texto breve la feria de semillas realizada este año en Chacsinkín, Yucatán, comunidad donde hace 20 años inició este proceso de intercambio y festejo de las semillas de la milpa. Refiere los antecedentes y organización de la feria, los actores involucrados, la ceremonia de agradecimiento y la secuencia del evento. El material proviene de la observación participante de los autores en dicha feria.
مستوى اداء المهارات المركبة بكرة القدم بدلالة الحرج الموقفي للطلاب
Authors: Aqeel Abbas Kadhem  , Prof. Dr. Haider Abdel Redha Trad  
Published: September 2024

هدفت الدراسة الحالية الى أعداد مقياس الحرج الموقفي لدى طلاب المرحلة الاولى بكلية التربية البدنية وعلوم الرياضة في جامعه بابل , تقنين المهارات المركبة بكرة القدم و مقياس الحرج الموقفي لدى طلاب المرحلة الاولى بكلية التربية البدنية وعلوم الرياضة في جامعة بابل والتعرف على مستوى اداء المهارات المركبة بكرة القدم والحرج الموقفي لدى الطلاب، معرفة العلاقة بين الحرج الموقفي من جهة و مستوى أداء المهارات المركبة بكرة القدم من جهة اخرى للطلاب, التنبؤ بمستوى اداء المهارات المركبة بداله الحرج الموقفي للطلاب واستخدم الباحثان المنهج الوصفي بأسلوب المسح والعلاقات الارتباطية لملائمة لطبيعة ومشكلة للبحث.
وتضمن مجتمع البحث طلاب المرحلة الاولى في كلية التربية البدنية وعلوم الرياضة في جامعة بابل للموسم الدراسي (2023-2024) والبالغ عددهم (274) طالبا، وبما أن عملية اختيار العينة ترتبط ارتباطاً وثيقاً بطبيعة ومجتمع البحث، لذا اختار الباحثان عينة البحث بالطريقة العشوائية البسيطة إذ بلغ عدد افراد العينة (110) طالبا, من مجتمع البحث مقسمة الى (10) طلاب عينة التجربة الاستطلاعية ، و(100) طالبا عينة للأعداد والتقنين والتطبيق، ولقد قام الباحثان بأعداد مقياس الحرج الموقفي وتقنين المهارات المركبة لطلاب المرحلة الاولى في كلية التربية البدنية وعلوم الرياضة في جامعة بابل على وفق السياقات العلمية المتبعة في اعداد وتقنين المهارات المركبة والمقياس النفسي، طبقت التجربة الرئيسية على العينة الرئيسية البالغ عددها(100) طالبا للأعداد والتقنين والتطبيق، للمتغيرات المهارات المركبة وللمقياس الحرج الموقفي ، ولاستخراج النتائج تم تفريغ البيانات ومعالجتها احصائياَ باستعمال الحقيبة الاحصائية (SPSS) .
A hybrid deep image prior and compressed sensing reconstruction method for highly accelerated 3D coronary magnetic resonance angiography
Authors: Xue Zhihao , Zhu Sicheng , Yang Fan , Gao Juan , Peng Hao , Zou Chao , Jin Hang , Hu Chenxi 
Published: September 2024

IntroductionHigh-resolution whole-heart coronary magnetic resonance angiography (CMRA) often suffers from unreasonably long scan times, rendering imaging acceleration highly desirable. Traditional reconstruction methods used in CMRA rely on either hand-crafted priors or supervised learning models. Although the latter often yield superior reconstruction quality, they require a large amount of training data and memory resources, and may encounter generalization issues when dealing with out-of-distribution datasets.MethodsTo address these challenges, we introduce an unsupervised reconstruction method that combines deep image prior (DIP) with compressed sensing (CS) to accelerate 3D CMRA. This method incorporates a slice-by-slice DIP reconstruction and 3D total variation (TV) regularization, enabling high-quality reconstruction under a significant acceleration while enforcing continuity in the slice direction. We evaluated our method by comparing it to iterative SENSE, CS-TV, CS-wavelet, and other DIP-based variants, using both retrospectively and prospectively undersampled datasets.ResultsThe results demonstrate the superiority of our 3D DIP-CS approach, which improved the reconstruction accuracy relative to the other approaches across both datasets. Ablation studies further reveal the benefits of combining DIP with 3D TV regularization, which leads to significant improvements of image quality over pure DIP-based methods. Evaluation of vessel sharpness and image quality scores shows that DIP-CS improves the quality of reformatted coronary arteries.DiscussionThe proposed method enables scan-specific reconstruction of high-quality 3D CMRA from a five-minute acquisition, without relying on fully-sampled training data or placing a heavy burden on memory resources.
CXCR1 and CXCR2 are potential neutrophil extracellular trap-related treatment targets in ulcerative colitis: insights from Mendelian randomization, colocalization and transcriptomic analysis
Authors: Xv Yichuan , Feng Yiyi , Lin Jiang 
Published: September 2024

ObjectivesThere is already substantial evidence indicating that neutrophil extracellular trap (NET) formation contributes to the inflammatory cascade in ulcerative colitis (UC). However, the precise regulatory mechanisms governing this process remain elusive. This study aimed to determine the role of NET-related genes in UC and reveal possible mechanisms.MethodsEmploying a two-sample MR methodology, we investigated the correlations between NET-associated genes (NRGs) and UC with summary data derived from a genome-wide association study (12,366 cases vs. 33,609 controls) and FinnGen (8,279 cases vs. 261,098 controls). The main analysis employed the inverse variance weighted method, supplemented by the MR-Egger method and weighted median method. Sensitivity analysis was conducted to rule out the interference of heterogeneity and pleiotropy among utilized instrument variables. The colocalization analysis was used to determine whether the identified NRGs and UC shared casual variants. Cross-tissue expression analysis was performed to characterize the expression patterns of target NRGs, while multi-gene correlation analysis and GSEA analysis were conducted to explore the mechanisms by which target NRGs promote UC and NET formation. Immunohistochemistry was used to validate the protein expression of target NRGs in the colon tissue of UC patients.ResultsAfter the validation of two datasets, seven NRGs were associated with the risk of UC. The higher expression of ITGB2 was associated with increased UC risk, while the expression of CXCR1, CXCR2, IRAK4, MAPK3, SIGLEC14, and SLC22A4 were inversely associated with UC risk. Colocalization analysis supported the correlation between CXCR1/2 and UC risk. Expression analysis indicated that CXCR1/2 were down-regulated in peripheral blood, but up-regulated in colon tissue. GSEA analysis and correlation analysis indicated that CXCR1/2 promoted UC and NET formation through neutrophil chemotaxis and PAD4-mediated pathways, separately. Immunohistochemical results confirmed the high expression of CXCR1/2 in colon tissues of UC patients.ConclusionsOur study identified CXCR1/2 as candidate targets in UC among all NRGs through multi-method argumentation, providing new insights of the regulation mechanisms of NET formation in the pathogenesis of UC.
Peripheral NK cell phenotypic alteration and dysfunctional state post hepatitis B subviral particles stimulation in CHB patients: evading immune surveillance
Authors: Selim Mohamed A , Suef Reda A. , Saied Ebrahim , Abdel-Maksoud Mostafa A. , Almutairi Saeedah Musaed , Aufy Mohammed , Mousa Adel A. , Mansour Mohamed T. M. , Farag Mohamed M. S. 
Published: September 2024

BackgroundThe relationship between chronic hepatitis B (CHB) infection and natural killer (NK) cell dysfunction is well-established, but the specific role of HBV viral antigens in driving NK cell impairment in patients with CHB remains unclear. This study investigates the modulatory effects of hepatitis B virus subviral particles (HBVsvp, a representative model for HBsAg) on the phenotypic regulation (activating and inhibitory receptors), cytokine production and cytotoxic potential of peripheral blood mononuclear cell-derived natural killer cells (PBMCs-derived NK cell), which contributes to NK cell dysfunction in CHB infection, potentially serving as an effective HBV immune evasion strategy by the virus.MethodsNK cells were isolated from peripheral blood of patients with CHB (n=5) and healthy individuals (n=5), stimulated with HBVsvp. Subsequent flow cytometric characterization involved assessing changes in activating (NKp46 and NKG2D) and inhibitory (CD94) receptors expression, quantifying TNF-α and IFN- γ cytokine secretion, and evaluating the cytotoxic response against HepG2.2.15 cells with subsequent HBVsvp quantification.ResultsIn CHB patients, in vitro exposure of PBMCs-derived NK cell with HBVsvp (represent HBsAg model) significantly reduced NK cell-activating receptors expression (P = 0.022), increased expression of CD94 + NK cells (p = 0.029), accompanied with a reduced TNF-α - IFN-γ cytokine levels, and impaired cytotoxic capacity (evidenced by increased cell proliferation and elevated HBVsvp levels in co-cultures with HepG2.2.15 cells in a time-dependent), relative to healthy donors.ConclusionThese findings suggest that HBVsvp may induce dysfunctional NK cell responses characterized by phenotypic imbalance with subsequent reduction in cytokine and cytotoxic levels, indicating HBVsvp immunosuppressive effect that compromises antiviral defense in CHB patients. These data enhance our understanding of NK cell interactions with HBsAg and highlight the potential for targeting CD94 inhibitory receptors to restore NK cell function as an immunotherapeutic approach. Further clinical research is needed to validate these observations and establish their utility as reliable biomarkers.
Immune responses and transcription landscape of adults with the third dose of homologous and heterologous booster vaccines of COVID-19
Authors: Zheng Hui , Li Cuidan , Zheng Xiuyu , Jiang Hu-Dachuan , Li Yuqing , Yao Aihua , Li Xiaolong , Wang Feiyu , Liu Wenqing , Cao Xiang , Qi Runjie , Chen Li , Jin Lairun , Zhu Fengcai , Li Jingxin , Chen Fei 
Published: September 2024

BackgroundHeterologous booster vaccines are more effective than homologous booster vaccines in combating the coronavirus disease 2019 (COVID-19) outbreak. However, our understanding of homologous and heterologous booster vaccines for COVID-19 remains limited.MethodsWe recruited 34 healthy participants from two cohorts who were primed with two-dose inactivated COVID-19 vaccine before, vaccinated with COVID-19 inactivated vaccine and adenovirus-vectored vaccine (intramuscular and aerosol inhalation of Ad5-nCoV) as a third booster dose. We assessed the immune responses of participants before and 14 days after vaccination, including levels of neutralizing antibodies, IgG, and cytokines, and quantified the transcriptional profile of peripheral blood mononuclear cells (PBMCs).ResultsThe Ad5-nCoV group showed a significantly higher neutralizing antibody geometric mean titer (GMT) compared to the ICV group after 14 days of heterologous boosting. The intramuscular Ad5-nCoV group had a GMT of 191.8 (95% CI 129.0, 285.1) compared to 38.1 (95% CI 23.1, 62.8) in the ICV1 group (p&lt;0.0001). The aerosolized Ad5-nCoV group had a GMT of 738.4 (95% CI 250.9-2173.0) compared to 244.0 (95% CI 135.0, 441.2) in the ICV2 group (p=0.0434). Participants in the aerosolized Ad5-nCoV group had median IFN-γ+ spot counts of 36.5 (IQR 15.3-58.8) per 106 PBMCs, whereas, both intramuscular Ad5-nCoV and CoronaVac immunization as the third dose showed lower responses. This suggests that a third dose of booster Ad5-nCoV vaccine (especially aerosolized inhalation) as a heterologous vaccine booster induces stronger humoral and cellular immune responses, which may be more potent against VOCs than the use of inactivated vaccine homologs. In transcriptomic analyses, both aerosolized inhalation/intramuscular injection of the Ad5-nCoV vaccine and inactivated vaccine induced a large number of differentially expressed genes that were significantly associated with several important innate immune pathways including inflammatory responses, regulation of the defense response, and regulation of cytokine production. In addition, we identified crucial molecular modules of protective immunity that are significantly correlated with vaccine type and neutralizing antibodies level.ConclusionThis study demonstrated that inhalation/intramuscular injection of the Ad5-nCoV vaccine-mediated stronger humoral and cellular immune responses compared with the inactivated vaccine, and correlated significantly with innate immune function modules, supporting a heterologous booster immunization strategy.
The hidden burden of female genital schistosomiasis: a cross-sectional study of knowledge, attitudes, and practices in Ghanaian communities
Authors: Manyeh Alfred Kwesi , Ekey Rosemond Akpene , Kamaldeen Rukaya Dongu , Fosu Dorothy , Vidzro Saviour Edem , Dalaba Maxwell 
Published: September 2024

BackgroundFemale genital schistosomiasis (FGS) is among the most neglected of tropical diseases. FGS remains underreported, under and misdiagnosed and mostly untreated. This neglected epidemic disproportionately affects communities already burdened by HIV and cervical cancer. The study aims to assess FGS knowledge, attitude, and practices and associated factors in communities in the Shai-Osudoku District of Ghana.MethodThe study employed an analytical cross-sectional design, utilizing quantitative methods for data collection from 161 community members. Analysis was conducted using STATA 18, included both descriptive statistics and simple logistic regression.ResultsAbout half (50.31%) of the respondents demonstrated poor knowledge of FGS. Furthermore, 65.84% of the respondents exhibited a poor attitude towards FGS, Poor practice related to FGS were also observed in 60.25% of the respondents. Regression analysis showed significant associations between various factors and knowledge, attitudes, and practices regarding FGS. Specifically, married women were found to have 54% lower odds of possessing good knowledge about FGS compared single women. (AOR=0.46, 95%CI= 0.22-0.94). Respondents with poor socioeconomic status displayed 76% higher odds of engaging in good practices compared to respondents those in the poorest socioeconomic status. (AOR=0.24, 95%CI=0.06-0.96).ConclusionComprehensive, context-specific interventions are necessary to address the multifaceted challenges associated with FGS. Targeted education and awareness campaigns are crucial to improve understanding of FGS, and addressing socio-economic factors that influence attitudes and practices related to the disease is essential.
Comparative efficacy and safety of belimumab and hydroxychloroquine in the maintenance phase in patients with systemic lupus erythematosus: a retrospective cohort study
Authors: Kimura Koichi , Ayano Masahiro , Ota Shun-Ichiro , Kushimoto Kazuo , Kimoto Yasutaka , Mitoma Hiroki , Ono Nobuyuki , Arinobu Yojiro , Akashi Koichi , Horiuchi Takahiko , Niiro Hiroaki 
Published: September 2024

ObjectivesHydroxychloroquine (HCQ), a cornerstone drug, is recommended for long-term use in treating systemic lupus erythematosus (SLE). However, in cases where HCQ is unavailable, it is unclear which drugs should be prioritised for continuation. We aimed to clarify whether belimumab (BLM), which has recently been reported to have long-term safety and efficacy, could be a viable alternative to HCQ.MethodsWe retrospectively compared the efficacy, drug continuation rate and safety of HCQ and BLM in the maintenance phase in patients with SLE. The efficacy endpoints were the cumulative incidence of flares over 2 years, the increase in the damage index and the changes in the SLE Disease Activity Index 2000 (SLEDAI) score and prednisolone dose. The safety endpoint was the adverse event rates.ResultsAmong 96 patients analysed, 15 out of 84 patients (17.9%) in the HCQ group and 1 out of 12 patients (8.3%) in the BLM group experienced a flare, with no significant difference in the cumulative incidence of flares between the two groups (p = 0.47). No differences were observed in the cumulative incidence of the increase in the damage index, changes in the SLEDAI score and prednisolone dose, drug continuation rates and adverse events.ConclusionsThe efficacy and safety of BLM were similar to those of HCQ. BLM could be a valuable treatment option for patients with SLE as an alternative for those who cannot tolerate HCQ.