bluuebunny/crossref_metadata_2025_split huggingface dataset:
Registry of Youth Onset Diabetes in India (YDR)
Authors: Praveen Pradeep A. , Madhu Sri Venkata , Mohan Viswanathan , Das Siddhartha , Kakati Sanjeeb , Shah Nalini , Chaddha Manoj , Bhadada Sanjay Kumar , Das Ashok Kumar , Shukla Deepak Kumar , Kaur Tanvir , Tandon Nikhil 
Published: May 2016

Background: With the aim of addressing the relative scarcity of information on youth-onset diabetes in India, the Indian Council of Medical Research (ICMR) decided to establish the Registry of People with Diabetes with Young Age at Onset (YDR) in 2006. The major objectives of YDR are to generate information on disease pattern or types of youth-onset diabetes including their geographical variations within India and to estimate the burden of diabetes complications. Methods: YDR is an observational multicenter clinic based registry enlisting physician diagnosed diabetes in individuals below 25 years of age. Diabetes was classified using symptom based clinical criteria. YDR data collection is coordinated through regional collaborating centers and their interacting reporting centers across India. A baseline and an annual follow-up proformas are used to obtain information on sociodemographic details, clinical profile, and anthropometric and laboratory measurements of the patients. Results: In phase 1, the registry has enrolled 5546 patients, in which type 1 diabetes mellitus (T1DM) was the most prevalent (63.9%), followed by youth-onset type 2 diabetes mellitus (T2DM) (25.3%). Conclusion: This registry provides a unique opportunity to study the natural history of youth-onset diabetes in India.
Demographic change and its social and political implications in the Middle East
Authors: Hamanaka Shingo 
Published: May 2016

This study examines the effect of the demographic trend on the breakdown of authoritarian regimes in the Middle East. Several scholars have pointed out that the combination of youth’s disproportionate share of the total population, the “youth bulge,” and high unemployment throws a society into turmoil. The demographic change determines not only how human activities are conducted but also how a society embarks on a political transition, such as a revolution, a state breakdown, or a regime change. I conduct two levels of empirical analysis of the political implications of the demographic dynamics in the Middle East. First, the macro-level analysis is based on cross-sectional data over two decades. This analysis will clarify whether the youth population had a significant effect on the Arab uprisings. Second, the micro-level analysis uses survey data from the Arab Democracy Barometer wave III to examine whether there is a significant correlation between youth and participation in protest. This analytical approach integrates the macro level with the micro level in order to avoid an ecological inference. My empirical analysis finds evidence to support Jack Goldstone’s revolution theory: it is built on demographic changes accompanied by rising food prices. The hypothesis is tested by examining the interactive effect of youth bulge and the deteriorating economic situation in the two decades following the end of the Cold War. The empirical tests at both the macro and micro levels identify a statistically significant effect.
Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP
Authors: Pillai Vikram G. , Bao Jialing , Zander Catherine B. , McDaniel Jenny K. , Chetty Palaniappan S. , Seeholzer Steven H. , Bdeir Khalil , Cines Douglas B. , Zheng X. Long 
Published: May 2016

Key PointsHNPs inhibit proteolytic cleavage of VWF by ADAMTS13 by physically blocking VWF-ADAMTS13 interactions. Plasma levels of HNP1, HNP2, and HNP3 are markedly increased in patients with acquired autoimmune TTP.
Can preoperative thyroglobulin antibody levels be used as a marker for well differentiated thyroid cancer?
Authors: Hosseini S. , Payne R. J. , Zawawi F. , Mlynarek A. , Hier M. P. , Tamilia M. , Forest V. I. 
Published: May 2016

Background It has been reported that thyroglobulin antibody are more frequently elevated in patients with thyroid cancercompared to general population. This study aims at evaluating whether preoperative thyroglobulin antibody (TgAb) levels increase the likelihood that a thyroid nodule is malignant. Methods A retrospective review of 586 patients who underwent thyroidectomy was conducted. Demographic data, TgAb levels, and final histopathology were recorded. Patients were divided into two groups: TgAb positive (defined as TgAb ≥ 30 IU/ml) and TgAb low/negative (defined as TgAb < 30). Results Preoperative TgAb levels were available in 405 patients. There were 353 (87 %) patients in the TgAblow/negative group (malignancy rate: 50.42 %) and 52 (13 %) patients in the TgAb positive group (malignancy rate: 65.38 %). The sensitivity, specificity, positive predictive value and negative predictive value of TgAb ≥ 30 IU/ml for thyroid malignancy were 16.04 %, 90.67 %, 65.38 % and 49.58 %, respectively. The relative risk of having a malignant thyroid nodule when the TgAb titers were≥30 IU/ml was 1.30 (CI1.04-1.62) and the odds ratio was 1.86 (CI 1.01-3.41). Both the Pearson chi-square test (p = 0.024) and Fisher's exact test (p = 0.017) yielded statistical significance between the two groups. Conclusions In this study, patients with preoperative TgAb ≥ 30 IU/ml had a higher rate of malignancy when compared topatients with TgAb < 30 IU/ml. This suggests that an elevated TgAb level may indicate that a thyroid nodule is at an increased risk for malignancy.
Perioperative Outcomes in Intracranial Pleomorphic Xanthoastrocytoma
Authors: Gaba Prakriti , Puffer Ross C. , Hoover Jason M. , Wharen Robert E. , Parney Ian F. 
Published: May 2016

Abstract

BACKGROUND: Patients with pleomorphic xanthoastrocytoma (PXA) routinely undergo multiple procedures to ensure recurrence-free survival and are resultantly at increased risk of experiencing perioperative complications (regional, medical, and/or neurological), a combination of which has not been recorded in previous studies.

OBJECTIVE: To determine perioperative outcomes in a cohort of patients (adult and pediatric) with intracranial PXA.

METHODS: We retrospectively identified 39 patients who underwent surgery at our institution for intracranial PXA between 1994 and 2011. Demographic factors were recorded along with Karnofsky Performance Status (KPS), complications, and mortality.

RESULTS: Mean patient age was 31 years at the most recent surgery. A majority of patients (24; 62%) had multiple surgeries with a mean of 2 operations per patient. Eleven PXAs (28%) were malignant (grade III or IV). Perioperative complications included permanent neurological worsening in 4 patients (10%), regional complications in 4 (10%), and medical complications in 3 (8%). Preoperative KPS was ≥70 in 34 of 38 patients (89%). Long-term postoperative KPS was ≥70 in 36 of 37 patients (97%), suggesting good functional outcomes. There was no perioperative mortality, but 7 patients (18%) died of tumor progression. Patients with malignant PXAs trended toward higher risk of regional complications (3 of 11 patients [27%]; P = .06), received adjuvant therapy more often (10 of 11 patients [91%]; P < .001), had higher mortality from tumor progression (7 of 11 patients [64%]; P < .001), and were significantly larger (mean, 6.05 ± 0.73 cm standard error of the mean; n = 7; P < .01).

CONCLUSION: Both pediatric and adult PXAs may be resected with good functional outcomes. Perioperative neurological complications are relatively common, but do not affect long-term functional outcome or mortality. Malignant PXAs are higher risk for perioperative complications and, ultimately, death from tumor progression, despite increased use of adjuvant radiation and chemotherapy.
Nuclear migration events throughout development
Authors: Bone Courtney R. , Starr Daniel A. 
Published: May 2016

ABSTRACT
Moving the nucleus to a specific position within the cell is an important event during many cell and developmental processes. Several different molecular mechanisms exist to position nuclei in various cell types. In this Commentary, we review the recent progress made in elucidating mechanisms of nuclear migration in a variety of important developmental models. Genetic approaches to identify mutations that disrupt nuclear migration in yeast, filamentous fungi, Caenorhabditis elegans, Drosophila melanogaster and plants led to the identification of microtubule motors, as well as Sad1p, UNC-84 (SUN) domain and Klarsicht, ANC-1, Syne homology (KASH) domain proteins (LINC complex) that function to connect nuclei to the cytoskeleton. We focus on how these proteins and various mechanisms move nuclei during vertebrate development, including processes related to wound healing of fibroblasts, fertilization, developing myotubes and the developing central nervous system. We also describe how nuclear migration is involved in cells that migrate through constricted spaces. On the basis of these findings, it is becoming increasingly clear that defects in nuclear positioning are associated with human diseases, syndromes and disorders.
Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland
Authors: Baker Leena , BeGora Michael , Au Yeung Faith , Feigin Michael E. , Rosenberg Avi Z. , Lowe Scott W. , Kislinger Thomas , Muthuswamy Senthil K. 
Published: May 2016

ABSTRACT
The cell polarity protein scribble (SCRIB) is a crucial regulator of polarization, cell migration and tumorigenesis. Whereas SCRIB is known to regulate early stages of mouse mammary gland development, its function in the adult gland is not known. Using an inducible RNA interference (RNAi) mouse model for downregulating SCRIB expression, we report an unexpected role for SCRIB as a positive regulator of cell proliferation during pregnancy-associated mammary alveologenesis. SCRIB was required in the epithelial cell compartment of the mammary gland. Lack of SCRIB attenuated prolactin-induced activation of the JAK2–STAT5 signaling pathway. In addition, loss of SCRIB resulted in the downregulation of prolactin receptor (PRLR) at cell surface and its accumulation in intracellular structures that express markers of the Golgi complex and the recycling endosome. Unlike its role in virgin gland as a negative regulator cell proliferation, SCRIB is a positive regulator of mammary epithelial cell proliferation during pregnancy.
Fan pleasure and profit: Use-value, exchange-value, and one-sixth scale action figure customization
Authors: Godwin Victoria L. 
Published: May 2016

Abstract
One-sixth scale action figure fans complicate existing fan studies models, which emphasize cultural or social capital over economic capital, and which minimize or erase fan activities involving potential profit to focus instead upon gift economies. One-sixth scale action figure customization and other material fan practices offer productive examples of how multiple fandoms incorporate both pleasure and profit, use-value and exchange-value, into their fan practices, and how they explain or justify such practices to those within and outside their fan communities. Customizers emphasize their creations’ use-value over exchange-value in three specific ways. First, customizers create items not offered by any company. Second, they create affordable alternatives to expensive official merchandise. Third, their projects remedy inferior aspects of officially licensed merchandise. Customizers modify existing products or create their own if they cannot find or afford desired items of appropriate quality. These justifications offer insights into how multiple other fandoms likewise frame any commercial efforts as emphasizing use-value over exchange-value. Such constructions of fan practices ward against legal and ethical complications of using licensed texts, characters, and/or merchandise as a base or inspiration for one’s own creative efforts.
Candy coloured ponies and pastel uniforms: Military Bronies and masculine innocence
Authors: Amon Maria Patrice 
Published: May 2016

Abstract
The Hasbro Company’s My Little Pony franchise began as a toy line marketed specifically to young girls; however, with the 2010 franchise reboot under the new title My Little Pony: Friendship Is Magic, an unanticipated and vocal following of adult men terming themselves ‘Bronies’ emerged as fans. As a focused subset of the brony community, ‘Military Bronies’ are challenging traditional expectations of masculinity and radically moving towards accessing formerly proscribed designations of innocence. The Military Brony phenomenon generates a sense of masculine innocence through the refutation of traditional cultural limitations on heteronormative masculinity.
From voice-body to sound-body: A phenomenological approach to the voice
Authors: Wilkins Caroline 
Published: May 2016

Abstract
This article concerns some phenomenological aspects of the voice with regard to an emergent form of performance embraced by the term Sound Theatre. Beginning from the context of a practical perspective, I discuss the impact of phenomenology on my own experience as a composer/performer. Within this framework my purpose is to define a method of analysis based on elements such as spacetime, memory and identity through an examination of the relationship between performer, voice, technology and audience. I draw on Merleau-Ponty’s phenomenology of gesture, a departure point for understanding the voice-body as medium in performance. Elaborating on this to include its interaction with technology in performance, I recall Hayles’s theory of post-humanism that proposes the existence of a three-way communication between humans, machines and audiences. Placed within a performance context, I argue that the voice itself can assume another presence, one that sheds former conventions and allows for it to speak differently, showing us other aspects of its being in its metamorphosis as a sound-body. Thus acknowledged, it assumes another thinking role within the creative process.
Extended vocal technique and Joan La Barbara: The relational ethics of voice on the edge of intelligibility
Authors: Bell Gelsey 
Published: May 2016

Abstract
This article explores vocalist and composer Joan La Barbara’s use of extended vocal technique, and its implications for imagining new kinds of ethical and political relationality with the voice. Focusing on her earliest composition, ‘Voice Piece: One-note internal resonance investigation’ (first premiered in 1974), the article examines her compositional process, tracking its development in the American experimental music tradition, and its relationship to improvisation and embodiment. Working outside of language and celebrating unconventional vocalizations, La Barbara’s music thrives on the dynamics of vocal discovery and mystery, realigning the voice away from customary modes of subjecthood based on speech and paralinguistic primary attributes, and towards a posthumanist vocality that does not seek to resolve all elements of foreignness. Drawing on theories from philosophers like Jacques Rancière and Judith Butler, the political and ethical concerns of the voice are re-examined within the locus of extended vocal technique as seen through La Barbara’s example.
Uluzuzulalia and the ‘Your Vivacious Voice’ project: A first report on collaborating with scientists to elicit children’s extra-normal voices
Authors: Bonenfant Yvon 
Published: May 2016

Abstract
Uluzuzulalia was a performance for children. It was developed as part of the larger ‘Your Vivacious Voice’ project, undertaken by practice-immersed researcher Yvon Bonenfant. This project aimed to elicit unusual vocalization from children aged 6–11 and their adults, and then celebrate the aesthetic sophistication and unruliness of the resultant sounds, as well as of the temporarily de-disciplined, or perhaps we might say re-disciplined, vocal bodies of the audience. Uluzuzulalia was a performancestyle experience that toured to theatre and music venues. This report article describes some of the key drivers that underpinned the project, articulates some of its results and makes a short, initial assessment of some of the challenges faced by the creative team and the respective solutions that were explored. The article sets the stage for further analytical writing on the project.
Reviews
Authors: Bonenfant Yvon , Soper Kate , Thomaidis Konstantinos , Bulut Zeynep 
Published: May 2016

Abstract
FOUNDATIONS OF VOICE STUDIES: AN INTERDISCIPLINARY APPROACH TO VOICE PRODUCTION AND PERCEPTION, JODY KREIMAN AND DIANA SIDTIS ([2011] 2013) Chichester: Wiley-Blackwell, 504 pp., ISBN: 9780631222972, h/bk, £89.95; ISBN: 9781118546703, p/bk, £29.95
CATHY BERBERIAN: PIONEER OF CONTEMPORARY VOCALITY, PAMELA KARANTONIS, FRANCESCA PLACANICA, ANNE SIVUOJAKAUPPALA AND PIETER VERSTRAETE (EDS) (2014) Surrey: Ashgate, 249 pp., ISBN: 9781409469834, h/bk, $119.95
SINGING THE BODY ELECTRIC: THE HUMAN VOICE AND SOUND TECHNOLOGY, MIRIAMA YOUNG (2015) 1st ed., Farnham, UK and Burlington, VT, USA: Ashgate, 223 pp., ISBN: 9780754669869, h/bk, $104.95
ON VOICE, WALTER BENHART AND LAWRENCE KRAMER (EDS) (2014) Amsterdam and New York: Rodopi, 252 pp., ISBN: 9789042038219, h/bk, $55.80
Considerations on conceptual frameworks for writing liminality into popular film
Authors: Theo LJ (Nic) 
Published: May 2016

Abstract
This article addresses the widely accepted, yet fictive dichotomy between the categories of ‘genre’ and ‘art’ film. These paradigms are perpetuated throughout the global film-making system by Hollywood norms that encourage screenwriters for popular films to write for genre category, rather than to reflect complex human experience in stories of liminality and interstitiality. An alternative conceptual framework for filmic narrative architecture that addresses these concerns can be developed out of the epistemological paradigm of ‘realism’ put forward by Birger Langkjaer. This construct is both-and-neither ‘genre’ and ‘art’, and enables a more grounded view of film narrative as composed of complex plots, characters and subject-matter/themes. However, in order to conceive of alternatives in ways that are pragmatically sound, account must be taken of how the profit-motives of Hollywood perpetuate dominant discourses. Such scholarship should also acknowledge the complexity of anthropological constructions of liminality, as well as the nature of film narrative as semiotic communication rendered to active (rather than passive) audiences. Taking account of these considerations, effective paradigmatic re-phrasing of film screenwriting can be engaged to encourage a philosophy of embodied experience in film practices, thereby reclaiming the power of subjectivity and voice in filmic narrative.
A professional history of screenwriters in Germany (1910–1945)
Authors: Scholz Juliane 
Published: May 2016

Abstract
This article outlines the emergence of screenwriters in Germany from 1910 until 1945. It focuses on the technological, cultural, social and political contexts and changing occupational environments that shaped screenwriting craft into an accepted media profession. German screenwriters were subsequently influenced by the ‘author film movement’ in the 1910s, and soon established a professional association to obtain professional status in 1919. Following the national socialist takeover in 1933, the political influence on German screenwriting became the main concern of their professional and creative practice. The article outlines the key events and patterns and how the occupation was shaped towards a creative profession, and describes the ways in which its professional history was influenced by institutional, political, cultural and industrial configurations.
Gabriel García Márquez’s Scriptwriting Workshop: Screenwriting pedagogy and collective screenwriting in Latin America
Authors: Arellano Jerónimo 
Published: May 2016

Abstract
This article explores three volumes published in Latin America in the 1990s under the banner ‘Gabriel García Márquez’s Scriptwriting Workshop’. These volumes compile transcripts of the workshops for Latin American screenwriters that the Nobel Laureate taught at the International Cinema and Television School in Santo Domingo de los Baños, Cuba, in the 1980s and 1990s. García Márquez’s scriptwriting workshops were practice-based and production-oriented, generating film and television scripts that were subsequently brought to the screen. Therefore, while these workshop texts were disseminated throughout Latin America as manuals for aspiring screenwriters, these collected transcripts also disclose processes of creative collaboration taking shape within localized industrial contexts. Drawing on contemporary research on screenwriting manuals, critical industrial practices and forms of corporate and situational authorship, this article explores García Márquez’s workshop as a window into the craft training of screenwriters and the development of forms of collective screenwriting emerging at the intersection of literary and cinema movements in Latin America.
Writing characters with intersex variations for television
Authors: Hart Phoebe 
Published: May 2016

Abstract
Throughout history, people with intersex variations have been positioned somewhere between ‘prodigy literature and pornography, mythology and medical discourse’. Contemporary representations have changed in step with societal values, yet it could be argued there is still slippage towards sensationalism. This article explores the writing of fictional characters with intersex variations for television. It is posited that screenwriters must go beyond limiting, stereotypical representations, and write characters with intersex variations ‘as an everyday social type’. Scripts that develop characters and narrative arcs in league with the intersex community rupture stigma and pre-inscription, defy current medical interference and promote ethical debates.
Reviews
Authors: Wells Paul , Rossholm Anna Sofia , Gorton Kristyn , Wells-Lassagne Shannon , Moore Cath , Peirse Alison 
Published: May 2016

Abstract
Screenwriting in the Digital Era, Kathryn Millard (2014) Basingstoke: Palgrave Macmillan: 256 pp., ISBN: 9781137319104, e-Book, $69.99; ISBN: 9780230343283, h/bk, $95.00; ISBN: 9781349344659, p/bk, $90.00
Teaching Adaptations, Deborah Cartmell and Imelda Whelehan (eds) (2014) Basingstoke: Palgrave Macmillian, 208 pp., ISBN: 9781137311122, h/bk, £55.00; ISBN: 9781137311153, p/bk, £18.90
Inside the Writers’ Room: Conversations with American TV Writers, Christina Kallas (2014) Basingstoke: Palgrave Macmillan, 184 pp., ISBN: 9781137338105, p/bk, £16.99
Time in Television Narrative: Exploring Temporality in Twenty-First-Century Programming, Melissa Ames (ed.) (2012) Jackson, MS: University Press of Mississippi, 337 pp., ISBN: 9781617032936, h/bk, $60.00; ISBN: 9781628461732, p/bk, $30.00
The Psychology of Screenwriting, Jason Lee (2013) New York, London: Bloomsbury Academic, 208 pp., ISBN: 9781441104984, h/bk, £40.50; ISBN: 9781441128478, p/bk, £16.99
Writing the Horror Movie, Marc Blake and Sara Bailey (2013) London: Bloomsbury Academic, 272 pp., ISBN: 9781441196187, p/bk, £16.99
Event Reviews
Authors: Osmond Dr Suzanne , Fajt Mateja , Pecorari Giulia , Choat Alyssa 
Published: May 2016

Abstract
CRITICAL COSTUME 2015 CONFERENCE AND EXHIBITION, AALTO UNIVERSITY, HELSINKI, 25–27 MARCH 2015
PATTERNS OF INEQUALITY: A REVIEW OF THE CRITICAL COSTUME 2015 CONFERENCE FROM A STUDENT PERSPECTIVE ON POWER STRUCTURES
CRITICAL COSTUME: A CONFERENCE AND EXHIBITION WHERE THEORY AND PRACTICE COME TOGETHER
NEW SPACES
Book Reviews
Authors: Matheson Linda , Pantouvaki Sofia 
Published: May 2016

Abstract
COSTUME: READINGS IN THEATRE PRACTICE, ALI MACLAURIN AND AOIFE MONKS (2015) London and New York: Palgrave Macmillan, 173 pp., 978-1-137-02948-5, Paperback
BEHIND THE SEAMS, JAMES BELLINI AND SALLY ANGEL (2015) London: Morris Angel & Son Ltd., 176 pp., 978-0-9932983-0-1, Hardback