bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Cytomegalovirus in Congenital and Early Postnatal Infections in Northeastern Bulgaria
Authors: Stoykova Zhivka D. , Ivanova Lilia I. , Todorova Tatina T. 
Published: October 2017

AbstractBackground:Human cytomegalovirus is a ubiquitous, large enveloped DNA β-herpesvirus that, like other herpesviruses, establishes lifelong latency following primary infection. It is the most frequent cause of congenital, neonatal and early postnatal infections with long lasting sequelae.Aim:The aim of the present study was to assess the prevalence of cytomegalovirus among a cohort of newborns and 1-3-month-old children with neurological symptoms, physical retardation, prolonged jaundice, thrombocytopenic purpura and other disabilities.Materials and methods:The study was a retrospective cross-sectional analysis of serological screening data for detection of specific anti-cytomegalovirus IgM and IgG in children from Northeastern Bulgaria.Results:Between 2003 and 2015, average prevalences of 18.8% (95% CI: 15.4 to 22.2) for anti-CMV IgM antibodies (suggesting acute infection) and 84.7% (95% CI: 81.6 to 87.8) for anti-CMV IgG antibodies were measured in a total number of 517 samples. The prevalence rate of anti-CMV IgM in 1-3-month-old children was 4-fold higher than that in newborns [25.8% (95% CI: 21.1 to 30.5) and 6.4% (95% CI: 2.9 to 9.9, respectively]. In contrast, no significant difference was found for anti- CMV IgG positivity between newborns and 1-3-month-old infants (84% and 85%, respectively).Conclusions:The data obtained strongly encourage screening of pregnant women for anti-CMV IgG and IgM to avoid transmission of the infection and severe complications of congenital infection.
Implementation of Instrument Based on Eight Health Related Quality of Life Domains for Measuring of Willingness to Pay for Psoriasis Treatment
Authors: Dobrev Hristo P. , Atanasov Nikolay G. , Dimitrova Donka D. 
Published: October 2017

AbstractBackground:Psoriasis vulgaris (PsV) is a chronic skin condition that has a major impact on health-related quality of life (HRQOL).Aim:To determine the individual burden of PsV on HRQOL using willingness to pay (WTP) instrument.Materials and methods:Fifty-one consecutive PsV patients were asked to evaluate their overall health and psoriasis affected health by visual analogue scale (VAS), and interviewed on 8 domains (physical, emotional, sleep, work, social, self-care, intimacy, and concentration) of HRQOL and WTP for a hypothetical cure in each domain. Two additional questions proposing 6 alternatives for therapy were also asked. The analysis is performed with descriptive and frequency statistics, Mann-Whitney and Kruskal-Wallis tests.Results:The domains ranked highly were: physical comfort (90%), social comfort (77%), emotional health (75%) and work (53%). The following tendencies concerning WTP for top four impacted domains were found: the median WTP were the highest in the top impacted domains; the younger patients were willing to pay more than the older ones; the highest median WTP amounts appear in the lowest income group; the highest median WTP is associated with smaller psoriasis affected health VAS scores. The largest proportion and number of patients (37.3%, n=19) stated preferences for the systemic therapy. The second preferred choice was the thalassotherapy (29.4%, n=15).Conclusions:The utility and reliability of the instrument based on the assessment of WTP stated preferences for 8 domains of HRQOL for evaluation the individual burden of psoriasis were strongly supported.
Application of Platelet-Rich Fibrin and Injectable Platelet-Rich Fibrin in Combination of Bone Substitute Material for Alveolar Ridge Augmentation - a Case Report
Authors: Chenchev Ivan L. , Ivanova Vasilena V. , Neychev Deyan Z. , Cholakova Radka B. 
Published: October 2017

AbstractBackground:Different barrier membranes and augmentation techniques are used in oral surgery to recover lost bone structures with varied success. Recently, a combination between bone graft materials and Platelet-Rich-Fibrin (PRF) is implemented in the periodontology and implantology.Aim: The aim of this case report was to assess the possibility for augmentation of the alveolar ridge in the frontal region of the upper jaw, utilizing a combination of bone graft material, injectable platelet-rich-fibrin (i-PRF) and advanced platelet-rich fibrin (A-PRF).Materials and methods:An 18 year-old male with expulsion of tooth 11 and partial fracture of the alveolar ridge was treated with augmentation of the alveolar ridge using bone graft material, injectable platelet–rich-fibrin(i-PRF) and advanced platelet-rich-fibrin (A-PRF). Clinical results were reviewed 4 months after the augmentation and a dental implant was placed.Results:The postoperative period was uneventful. The control CBCT scan showed good organization of new bone allowing placement of a dental implant.Conclusion:The successful clinical and radiographic results of the case suggest that using A-PRF and i-PRF can be beneficial for bone augmentation of the alveolar ridge before implant placement.
Community Noise Exposure and its Effect on Blood Pressure and Renal Function in Patients with Hypertension and Cardiovascular Disease
Authors: Dzhambov Angel M. , Tokmakova Mariya P. , Gatseva Penka D. , Zdravkov Nikolai G. , Gencheva Dolina G. , Ivanova Nevena G. , Karastanev Krasimir I. , Vladeva Stefka V. , Donchev Aleksandar T. , Dermendzhiev Svetlan M. 
Published: October 2017

AbstractBackground:Road traffic noise (RTN) is a risk factor for cardiovascular disease (CVD) and hypertension; however, few studies have looked into its association with blood pressure (BP) and renal function in patients with prior CVD.Aim:This study aimed to explore the effect of residential RTN exposure on BP and renal function in patients with CVD from Plovdiv Province.Materials and methods:We included 217 patients with ischemic heart disease and/or hypertension from three tertiary hospitals in the city of Plovdiv (March – May 2016). Patients’ medical history, medical documentation, and medication regimen were reviewed, and blood pressure and anthropometric measurements were taken. Blood samples were analyzed for creatinine, total cholesterol, and blood glucose. Participants also filled a questionnaire. Glomerular filtration rate was estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. All participants were asked about their annoyance by different noise sources at home, and those living in the city of Plovdiv (n = 132) were assigned noise map Ldenand Lnightexposure. The effects of noise exposure on systolic blood pressure (SBP), diastolic blood pressure (DBP), and estimated glomerular filtration rate (eGFR) were explored using mixed linear models.Results:Traffic noise annoyance was associated with higher SBP in the total sample. The other noise indicators were associated with non-significant elevation in SBP and reduction in eGFR. The effect of Ldenwas more pronounced in patients with prior ischemic heart disease/stroke, diabetes, obesity, not taking Ca-channel blockers, and using solid fuel/gas at home. Lnighthad stronger effect among those not taking statins, sleeping in a bedroom with noisy façade, having a living room with quiet façade, and spending more time at home. The increase in Ldenwas associated with a significant decrease in eGFR among men, patients with ischemic heart disease/stroke, and those exposed to lower air pollution. Regarding Lnight, there was significant effect modification by gender, diabetes, obesity, and time spent at home. In some subgroups, the effect of RTN was statistically significant.Conclusions:Given that generic risk factors for poor progression of cardiovascular diseases cannot be controlled sufficiently at individual level, environmental interventions to reduce residential noise exposure might result in some improvement in the management of blood pressure and kidney function in patients with CVD.
The development of the glass industry in central Vietnam
Authors: Mikoláš Milan , Drenda Jan , Pechar Tomáš , Tvrdý Jaromír , Mikoláš Martin , Mikušinec Jozef , Abrahámovský Ján , Néč Bohumil 
Published: October 2017

Abstract
A modern society is characterized by functional infrastructure and sufficient number and variety of materials in the form of various technical goods. All these civilization achievements are not only the result of human skills, but their material principles are based on industrial minerals. This group of materials includes a wide range of the natural raw materials which are used in many industries. This includes the raw materials for the manufacture of glass, ceramics or fillers. In 2014 was complete three-year international development aid project under the title “The Development of the Glass Industry in Central Vietnam”. The aim of the project was to find suitable sources of raw materials in formulations for glass production based on previously proven Phong Dien deposit of glass sand. Works carried out for the Czech Development Agency the GET Company from Czech Republic, Prague. In addition to the optimisation of the glass batch, detailed technological research was also implemented with the goal of achieving the full utilisation of Vietnamese raw materials for the manufacture of high quality glass. The production programme may be varied - focusing not only on the purest crystal type glass, but also on flat glass and container glass and even coloured glass.
Hard (bituminous) coal resources in Poland – expectations and reality
Authors: Sermet Edyta , Nieć Marek , Chećko Jarosław 
Published: October 2017

AbstractThere are numerous enthusiastic opinions on UCG possibilities. UCG is presented often as suitable for the utilization of coal resources which are inaccessible or difficult for conventional mining. Application of UCG coal basins in Poland is limited by their specific geological features. The most important are: hydrogeological and tectonic restraints, the occurrence of numerous coal seams with which gasification will interact, and the predominance of thin coal seams, less than 1.5 m thick. The detailed evaluation of hard (bituminous) coal resources in Poland explored up to 1.000 m depth, and careful selection of possible UCG sites has demonstrated that only about 10% of it may be gasified underground. Reasonable resource utilization is a serious problem in the multi-seam coal deposits. Coal resources are a nonrenewable part of the environment. Therefore, reasonable resources utilization is defined as their best possible recovery (considering acceptable costs). At the recent state of knowledge on UCG, its application in Poland, contrary to the former expectations, is seriously restrained.
Discount rate selection for long-term sequential mineral projects
Authors: Saługa Piotr W. 
Published: October 2017

AbstractMineral projects depict various specific features that differentiate them from alternative investments in other industries. Among these features, one can specify unique characteristics of mineral deposits such as scarcity, geological setting and structure, resource/reserve uncertainty and depletability. Resource uncertainty results in the sequential nature of operations (exploration, development and production stages). Other specific features of mineral projects include long investment - and production periods, high capital intensity, varying production conditions, unpredictability and high volatility of mineral prices, etc. Specific features of mineral projects are sources of exceptionally high risks. To ensure the payback of high capital costs these significant risks must be addressed in the economic evaluation of a mineral project. In the discounted cash flow analysis, DCF, which is the most commonly used in evaluations of such ventures, all project uncertainties are reflected in a level of the discount rate used for the actualization of future cash flow values. The riskier project has a higher discount rate. Apart from being extremely high risk, mineral projects are both sequential and long-term - the first feature means that the extent of a project risk decreases dramatically over time, and second - that care should be taken when evaluating these projects because cash flows arising in later years of the project lifetime have little value. The paper delivers a proposal to apply the time-varying discount rate to the economic evaluation of a mineral project. The first part introduces a commonly accepted approach to evaluating discount rates along with conceptions of adjusting them to risks of individual projects. In the following sections, the article presents the current practice in the setting of discount rates for mineral projects and then a proposed modification of this approach by introducing the time-varying discount rate. In the end, a verification of the proposed suggestion based on a copper project example has been delivered.
Methods of improvement chalcedonite processing effectiveness with the use of density separation
Authors: Naziemiec Zdzisław , Pichniarczyk Paweł , Saramak Daniel 
Published: October 2017

Abstract
The article regards the issues related to chalcedonite processing by means of particle size classification as well as densimetric separation. Chalcedonite is an unique rock and material with wide industrial applications in various industries. The investigative program included laboratory tests of chalcedonite classification in the classifier and the jig, as well as separation of the material in the dense liquid. The obtained results indicate that the products of particle size classification of chalcedonite in the classifier are characterized by a different chemical and mineralogical composition. The 0-0.3 mm particle size fraction contains over 96% of quartz, while the fine size fraction below 0.063 mm contain about 80% of quartz and 20% of clayish minerals. In the next stage of the investigative program, the densimetric separation of chalcedonite material in the jig and in dense liquid, was carried out. The results of the density classification in the jig indicate the different absorbability of the obtained chalcedonite density fractions. Fractions with a higher density were characterized by lower water absorption. The results of separation in the dense media liquid also showed that the obtained aggregate products are of significant differences in absorbability as well as high variability of the strength parameters. The results of the investigations show that the obtained products of the classification can be more efficiently utilized in industry, due to their diverse chemical and physical characteristics.
How to get rid of mitochondria: crosstalk and regulation of multiple mitophagy pathways
Authors: Zimmermann Marcel , Reichert Andreas S. 
Published: October 2017

AbstractMitochondria are indispensable cellular organelles providing ATP and numerous other essential metabolites to ensure cell survival. Reactive oxygen species (ROS), which are formed as side reactions during oxidative phosphorylation or by external agents, induce molecular damage in mitochondrial proteins, lipids/membranes and DNA. To cope with this and other sorts of organellar stress, a multi-level quality control system exists to maintain cellular homeostasis. One critical level of mitochondrial quality control is the removal of damaged mitochondria by mitophagy. This process utilizes parts of the general autophagy machinery, e.g. for the formation of autophagosomes but also employs mitophagy-specific factors. Depending on the proteins utilized mitophagy is divided into receptor-mediated and ubiquitin-mediated mitophagy. So far, at least seven receptor proteins are known to be required for mitophagy under different experimental conditions. In contrast to receptor-mediated pathways, the Pink-Parkin-dependent pathway is currently the best characterized ubiquitin-mediated pathway. Recently two additional ubiquitin-mediated pathways with distinctive similarities and differences were unraveled. We will summarize the current state of knowledge about these multiple pathways, explain their mechanism, and describe the regulation and crosstalk between these pathways. Finally, we will review recent evidence for the evolutionary conservation of ubiquitin-mediated mitophagy pathways.
The inhibition of the mitochondrial F1FO-ATPase activity when activated by Ca2+ opens new regulatory roles for NAD+
Authors: Nesci Salvatore , Trombetti Fabiana , Ventrella Vittoria , Pirini Maurizio , Pagliarani Alessandra 
Published: October 2017

Abstract
The mitochondrial F1FO-ATPase is uncompetitively inhibited by NAD+ only when the natural cofactor Mg2+ is replaced by Ca2+, a mode putatively involved in cell death. The Ca2+-dependent F1FO-ATPase is also inhibited when NAD+ concentration in mitochondria is raised by acetoacetate. The enzyme inhibition by NAD+ cannot be ascribed to any de-ac(et)ylation or ADP-ribosylation by sirtuines, as it is not reversed by nicotinamide. Moreover, the addition of acetyl-CoA or palmitate, which would favor the enzyme ac(et)ylation, does not affect the F1FO-ATPase activity. Consistently, NAD+ may play a new role, not associated with redox and non-redox enzymatic reactions, in the Ca2+-dependent regulation of the F1FO-ATPase activity.
Crop residue recycling for economic and environmental sustainability: The case of India
Authors: Devi Saroj , Gupta Charu , Jat Shankar Lal , Parmar M.S. 
Published: October 2017

Abstract
India is one of the key producers of food grain, oilseed, sugarcane and other agricultural products. Agricultural crops generate considerable amounts of leftover residues, with increases in food production crop residues also increasing. These leftover residues exhibit not only resource loss but also a missed opportunity to improve a farmer’s income. The use of crop residues in various fields are being explored by researchers across the world in areas such as textile composite non-woven making processes, power generation, biogas production, animal feed, compost and manures, etc. The increasing trend in addition of bio-energy cogeneration plants, increasing demand for animal feedstock and increasing trend for organic agriculture indicates a competitive opportunity forcrop residue in Agriculture. It is to be noted that the use of this left over residue isoften not mutually exclusive which makes measurement of its economic value more difficult.For example, straw can be used as animal bedding and thereafter as a crop fertilizer. In view of this, the main aim of this paper envisaged to know about how much crop residue is left unutilized and how best they can be utilized for alternative purposes for environmental stewardship and sustainability. In this context, an attempt has been made to estimate the total crop residue across the states and its economic value though data available from various government sources and a SWOT analysis performed for possible alternative uses of residue in India. This paper also discusses the successful case studies of India and global level of use of crop residues in economic activities. Over all 516 Mtonnes of crop residue was produced in 2014-15 in India among which cereals were the largest producer of crop residue followed by sugarcane. The energy potential from paddy rice straw crop residue was estimated as 486,955 megawatt for 2014-15 and similarly for coarse cereals it was 226,200megawatt.
The effect of environmental conditions on the content of selected micronutrients in spelt grain
Authors: Knapowski Tomasz , Kozera Wojciech , Wszelaczyńska Elżbieta , Pobereżny Jarosław , Cieślewicz Joanna , Chmielewski Jarosław 
Published: October 2017

Abstract
The aim of the study was to determine the effect of application of small amounts of nitrogen to the soil together with foliar application of micronutrients on the content of copper, manganese and zinc in the grain of spelt (Triticum aestivum ssp. spelta L.). The study was based on a two-factor field experiment conducted in 2009–2011 on very good rye complex soil. Nitrogen was applied in the form of ammonium nitrate (34% N), and manganese and copper were applied to the leaves in the form of the fertilisers Adob Mn (1.5 l∙ha−1) and Adob Cu (1.0 l∙ha−1), respectively. The results indicated that the nitrogen fertilisation, the foliar application of micronutrients and the interaction of these factors significantly determined the contents of copper, manganese and zinc in the grain. The highest content of Cu and Mn in the material was obtained following the application of 50 kg N·ha−1, and an increase in nitrogen application (to 50 kg·ha−1) caused a decrease in the content of zinc in the grain. Foliar application of Cu, Mn and both elements together resulted in significant changes in the concentrations of Cu, Mn and Zn in the plant material as compared to treatment without the application of micronutrients. The mineral fertilisers at the rates applied had a beneficial effect on the chemical composition of the grain, and thus on its quality, and this was achieved with substantially lower consumption of agrochemicals than that in the case of agrotechnical procedures for traditional cereals. It can, therefore, be concluded that this practice is environment friendly and can significantly reduce the negative impact of agricultural activity.
Reducing Flood Risk using Computer System for Monitoring River Embankments
Authors: Chuchro Monika , Franczyk Anna , Bukowska-Belniak Barbara , Leśniak Andrzej 
Published: October 2017

Abstract
In order to learn about the phenomena occurring in flood embankment under the influence of external factors, including the increasing water level in the river during floods, a Computer System for Monitoring River Embankment (ISMOP) was developed using an experimental flood embankment. The project was carried out by a consortium consisting of AGH University of Science and Technology departments (Computer Science, Hydrogeology and Engineering Geology, Geoinformatics and Applied Computer Science and two companies (NEOSENTIO and SWECO Hydroprojekt Kraków) in co-operation with the Czernichów Community Council.
An experimental flood embankment was built with two parallel sections with a length of 150 m and a height of 4.5 m, connected by a meandering, creating a reservoir that can be filled with water. For the construction of the embankment, different types of soils were used in all the five sections. Inside the flood embankment 1300 sensors are placed, including sensors for temperature, pore pressure, vertical displacements, as well as inclinometers. Also fiber optic strands, capable of measuring the temperature of the flood embankment on the upstream side, are located inside the experimental embankment [ismop.pl].
Together with the real experiments, numerical modelling using the Itasca Flac 2D 7.0 was performed in order to describe the impact of water pressing on the flood embankment and the impact of increasing and decreasing reservoir water level on the phenomena that occur within the embankment.
The results of modelling compared with the real sensor data allowed the evaluation of the current and future state of the embankment. Based on the data measured by the sensors and data received during the numerical modelling, a group of algorithms that allowed detection of anomaly phenomena was developed.