bluuebunny/crossref_metadata_2025_split huggingface dataset:
Patient-reported outcomes in cancer survivorship: insights from two decades of population-based PROFILES registry research
Authors: Mols Floortje , Schoormans Dounya , Oerlemans Simone , Horevoorts Nicole , Ezendam Nicole , Raijmakers Natasja , van de Poll-Franse Lonneke 
Published: October 2024

Abstract
Purpose
When the field of cancer survivorship research was in its infancy, the PROFILES registry was set up in 2004 to monitor patient-reported outcomes (PROs) in survivors and a normative population. This scoping review aims to summarize lessons learned from developing a population-based PRO registry, focusing on study methodologies, data collection shifts, data utilization, multidisciplinary collaboration, societal impact, and data sharing.

Methods
A systematic computerized literature search through PubMed was performed to collect all publications using data from the PROFILES registry between January 1, 2004, and December 31, 2023.

Results
The PROFILES registry’s research today encompassed 249 papers from 35 studies. Key insights include the importance of multi-hospital collaboration, which enhances participant inclusion and result generalizability. Optimizing response rates and patient inclusion is achieved through proactive data collection methods such as inclusion by health care professionals, and using both web-based and paper questionnaires. Longitudinal studies, despite their intensive data collection efforts, provide critical insights into the consequences of cancer and its treatment on patient-reported outcomes (PROs) from diagnosis through survivorship. Combining PRO data with comprehensive clinical registry data ensures reliable datasets, crucial for drawing meaningful conclusions. The shift towards multidisciplinary collaboration, open-access publishing, and data sharing all contribute to accessible and impactful research.

Conclusions
This review highlights key insights from the PROFILES registry, emphasizing multi-hospital collaboration, proactive data collection, and the integration of PROs with clinical data.

Implications for Cancer Survivors
These lessons can guide future research on cancer survivorship, improving methodologies to enhance survivorship care and quality of life through multidisciplinary collaboration and data sharing.
Towards the cost of health in Africa: examining the synergistic effect of climate change and renewable energy on health expenditure
Authors: Horvey Sylvester Senyo 
Published: October 2024

AbstractClimate change has become the centre of discussion among scholars and practitioners globally. This is believed to have severe consequences for the environment and human health, leading to significant implications for health financing. However, empirical investigations examining the climate change-health nexus remain scarce and underexplored. Hence, this study contributes to knowledge by exploring the direct and synergistic influence of renewable energy and climate change on health expenditure (i.e., national, public, private and external) in Africa. The study employs annual data from a panel of 47 African countries between 2006 and 2019, which are estimated using the generalised method of moments. Robustness checks are performed using alternative proxies for climate change and the Driscoll-Kraay estimation technique. The empirical outcomes reveal that high CO2 emissions increase the various indices of health expenditure, implying environmental degradation triggers higher costs in health spending. The empirical results further show that renewable energy presents a negative and significant influence on health expenditure, showing that health expenditure decreases due to the adoption of renewable energy. Additionally, the study finds that renewable energy weakens the effect of carbon emissions on health spending, including public, private and external health expenditures. This implies that the severe impact of climate change on health expenditure is reduced through the intervening role of renewable energy sources. The study recommends that policymakers implement targeted policies towards reducing carbon emissions and increasing renewable energy consumption to improve health outcomes. Governments must also promote universal health coverage to ensure inclusive coverage as climate change becomes increasingly apparent.
Clinical Implications of the Molecular and Genomic Landscape of Upper Tract Urothelial Carcinoma
Authors: Jaime-Casas Salvador , Tripathi Abhishek , Pal Sumanta K. , Yip Wesley 
Published: October 2024

Abstract
Purpose of Review
Upper tract urothelial carcinoma (UTUC) is an aggressive entity with treatment strategies mirroring bladder cancer. Genomic and molecular profiling allows for a better characterization of this disease and allows for patient-tailored approaches. We aim to describe the genomic and molecular implications of this disease.

Recent Findings
Technological advances have the potential for early diagnosis and precise molecular analysis in patients with UTUC. Genomic profile clustering, specific mRNA signatures, and pathway-specific protein abundance tools have oncologic and clinical implications. We describe their utility in the context of this disease.

Summary
In the era of precision medicine, designing clinical trials that explore the diagnostic and prognostic implications of biomolecular signatures in the context of UTUC is of utmost importance. Promising advances in this arena provide tools for physicians to avoid overtreatment in this patient population.
Prosecuting human traffickers in Nigeria: victim-witnessing and community-oriented challenges
Authors: Okorie Mitterand M. , Okeja Uchenna 
Published: October 2024

AbstractThe paper reflects on the limitations of Nigeria’s antitrafficking efforts, as they relate, particularly, to the complexities of victim-witnessing in the prosecution of sex trafficking cases. While much has been written about the institutional and cultural impediments to victim-witnessing in Nigeria or Nigerian-related sex trafficking cases, our work seeks to ask an often underplayed, if not ignored question: Can individuals existing under unjust structures find the impetus to assist the state advance the course of justice? We respond to this question by exploring the interrelationships between political failure, community-oriented trafficking and the moral quandary faced by intercepted victims who see trafficking as a conduit for economic mobility. Utilising Robert Merton’s strain theory, we highlight how the relational dynamics between traffickers and their victims within a community-oriented trafficking context underscore an innovation adjustment to the Mertonian strain. Against this background, we conclude that victim-witnessing is and will remain a challenge for Nigeria’s criminal justice response to trafficking because victims perceive their criminal exploiters as inextricably linked to their material wellbeing.
Personality traits as predictors of forgiveness and gratitude/awe: a two-wave longitudinal study
Authors: Skalski-Bednarz Sebastian Binyamin , Toussaint Loren L. , Konaszewski Karol , Surzykiewicz Janusz 
Published: October 2024

AbstractCross-sectional studies have shown that individual differences can be associated with pro-social emotions. However, little is known about how personality may predict subsequent forgiveness and gratitude/awe. This study investigates the longitudinal influence of the Big Five traits (assessed by the Ten-Item Personality Inventory), supplemented by narcissism (assessed by the Single Item Narcissism Scale), on decisional and emotional forgiveness (assessed by the Decisional and Emotional Forgiveness Scales), as well as gratitude/awe (assessed by the Gratitude/Awe Questionnaire). Data were gathered from 292 respondents (64% women) from Poland who completed questionnaires at Time 1 (T1) and 6 months later at Time 2 (T2). Structural equation modelling showed that agreeableness at T1 positively predicted decisional forgiveness at T2; extraversion at T1 and emotional stability at T1 positively predicted emotional forgiveness at T2; and openness at T1 positively predicted gratitude/awe at T2, albeit all effects were weak. Our findings suggested that personality traits play a more minor role than one might think based on cross-sectional studies in determining individuals’ capacity for forgiveness and gratitude/awe. However, it is essential to note that these results are specific to the Polish population, underscoring the necessity for future research incorporating a more diverse demographic representation.
Aerosol loading in the guinea coast climate region of Nigeria: comparison of MODIS and AERONET data sources
Authors: Ibe Onyinyechi Caroline , Nwofor Okechukwu Kelechi , Okoro Ugochukwu Kingsley 
Published: October 2024

AbstractThis study compares aerosol optical depth (AOD) measurements from satellite data with that from a ground-based station. It aims at validating monthly AOD data from the Moderate Resolution Imaging Spectroradiometer (MODIS) Deep Blue (DB) collection 6.1 (Aqua and Terra) at 550 nm against AOD data from the Aerosol Robotic Network (AERONET) station at 500 nm in Ilorin over the period 2003–2022. The analysis focuses on eight selected cities/locations within the Guinea Coast region of Nigeria. Descriptive and inferential statistical methods, including correlation, regression, standard deviation, coefficient of variation, the Mann–Kendall trend test, root mean square error (RMSE), mean absolute error (MAE), and relative mean bias (RMB), were employed. The results indicate a positive correlation in most locations, with correlation values ranging from 0.3 to 0.7. The correlation between the datasets in Ilorin showed a positive and significant relationship while the other seven locations presented a weak and insignificant relationship. Additionally, the period from 2013–2022 showed better correlation compared to 2003–2012. AOD levels were highest during the harmattan season (DJF), exceeding 0.8, and lowest during the monsoon (JJA) and post-monsoon (SON) seasons, with values below 0.5, reflecting the effects of wet scavenging. The highest agreement between MODIS Aqua and AERONET data was observed during the harmattan season. The study also found that MODIS tends to overestimate AOD compared to AERONET and that MODIS-AOD exhibits greater spread and variability than AERONET-AOD.
Cloud detection for HY-1C/COCTS over the ocean based on spectral-and-textural-information-guided deep neural network
Authors: Liu Fanli , Liu Mingkun , Sheng Zhicheng , Guan Lei 
Published: October 2024

AbstractGiven that clouds can absorb and scatter radiation signals in the visible and infrared bands, cloud detection is a key preprocessing step for ocean color and sea surface temperature retrievals. In this research, a Spectral-and-Textural-Information-Guided deep neural Network (STIGNet) is designed for cloud detection in global ocean data from the Haiyang-1C (HY-1C)/Chinese Ocean Color and Temperature Scanner (COCTS). Considering the spectral and textural properties of clouds, the model incorporates HY-1C/COCTS spectral data, differences in brightness temperature (BT), local statistical characteristics of BT, and geographical location information–all of which are closely related to cloud features. Notably, an edge learning module is implemented to emphasize edge features during the training process. We construct a HY-1C/COCTS cloud detection dataset to train and test the cloud detection model. In the dataset, labels are generated by combining the Bayesian cloud detection method with a manual mask. Analysis of the resulting cloud detection images indicates that STIGNet exhibits accurate performance across various types of clouds while showing minimal overestimated errors in areas such as ocean fronts or sun glints, where they tend to occur frequently. The ablation experiments performed on physical-based input features and edge learning modules show enhancements in cloud detection accuracy. Evaluation results demonstrate an overall accuracy of 96.64%, with a cloud overestimated error of 1.61% and a cloud missed error of 1.76%. These findings highlight the effectiveness of STIGNet in generating precise cloud masks for HY-1C/COCTS data.
Informing estimates of probability of Clostridioides difficile infection for testing and treatment: expert consensus from a modified-Delphi procedure
Authors: Baghdadi Jonathan D. , Wessel Mia , Dubberke Erik R. , Lydecker Alison , Claeys Kimberly C. , Alonso Carolyn , Coffey K.C. , Durkin Michael , Gonzales-Luna Anne J. , Guh Alice Y. , Kwon Jennie H. , Martin Elise , Mehrotra Preeti , Polage Christopher R. , Pulia Michael S. , Rock Clare , Skinner Andrew M. , Vaughn Valerie M. , Vijayan Tara , Yarrington Michael E. , Morgan Daniel J. ,   for the CDC Prevention Epicenters Program
Published: October 2024

Abstract

Background:
Clostridioides difficile infection (CDI) may be misdiagnosed if testing is performed in the absence of signs or symptoms of disease. This study sought to support appropriate testing by estimating the impact of signs, symptoms, and healthcare exposures on pre-test likelihood of CDI.

Methods:
A panel of fifteen experts in infectious diseases participated in a modified UCLA/RAND Delphi study to estimate likelihood of CDI. Consensus, defined as agreement by >70% of panelists, was assessed via a REDCap survey. Items without consensus were discussed in a virtual meeting followed by a second survey.

Results:
All fifteen panelists completed both surveys (100% response rate). In the initial survey, consensus was present on 6 of 15 (40%) items related to risk of CDI. After panel discussion and clarification of questions, consensus (>70% agreement) was reached on all remaining items in the second survey. Antibiotics were identified as the primary risk factor for CDI and grouped into three categories: high-risk (likelihood ratio [LR] 7, 93% agreement among panelists in first survey), low-risk (LR 3, 87% agreement in first survey), and minimal-risk (LR 1, 71% agreement in first survey). Other major factors included new or unexplained severe diarrhea (e.g., ≥ 10 liquid bowel movements per day; LR 5, 100% agreement in second survey) and severe immunosuppression (LR 5, 87% agreement in second survey).

Conclusion:
Infectious disease experts concurred on the importance of signs, symptoms, and healthcare exposures for diagnosing CDI. The resulting risk estimates can be used by clinicians to optimize CDI testing and treatment.
Documented penicillin allergy and beta-lactam antibiotic use in Massachusetts long-term care facilities: opportunities for penicillin allergy delabeling
Authors: Foong Kap Sum , Doron Shira , Fowle Leslie , Cumming Melissa , Leaf Jessica , Bolstorff Barbara , Brandeburg Christina , Chen Ye , Wurcel Alysse 
Published: October 2024

Abstract
In a cross-sectional study of 20 Massachusetts long-term care (LTC) facilities, 19% (n = 449) of residents received antibiotics, with approximately one-third having a documented penicillin allergy. This documented allergy decreased the likelihood of prescribing beta-lactam antibiotics for infections. Improved penicillin allergy assessments and delabeling could optimize antibiotic prescribing in LTC settings.
How utility-scale solar energy generation on rehabilitated mine lands can contribute to decarbonising the resources sector
Authors: Purtill James 
Published: October 2024

Abstract
Many governments globally have climate change targets requiring rapid decarbonisation, calling for significant renewable energy generation. Utility-scale solar arrays will consume large swathes of land. Rehabilitated mine lands present a unique opportunity to host renewable utility-scale solar and reduce land use conflicts. There is however, to date, insufficient in-depth discussion of this opportunity and barriers to implementation in the academic literature. This paper describes challenges facing the resources industry, using Queensland’s coal sector as a case study, then outlines some of the opportunities that accompany those challenges. Five reasons for reassessing the role of rehabilitated lands for utility-scale solar energy generation are presented – increasing demand for renewable energy, the global decarbonisation agenda, transformation in regional mining economies, as a progressive rehabilitation and post-mining land use, and a solution to reduce land use conflict. The barriers, perceived and actual, must be addressed and broken down to facilitate greater uptake of utility-scale solar onto rehabilitated mine lands. This can allow for a more orderly energy transition, and growth in renewable energy production that matches decarbonising and energy demand pathways, in the right locations and at the right time – with good planning and industry support.
Dejustifying Scientific Progress
Authors: Dellsén Finnur , Norton James 
Published: October 2024

Abstract
Stegenga (forthcoming) formulates and defends a novel account of scientific progress, according to which science makes progress just in case there is a change in scientific justification. Here, we present several problems for Stegenga’s account, concerning, respectively, (i) obtaining misleading evidence, (ii) losses or destruction of evidence, (iii) oscillations in scientific justification, and (iv) the possibility of scientific regress. We conclude by sketching a substantially different justification-based account of scientific progress that avoids these problems.
A PROOF OF HIRSCHHORN’S CONJECTURE ON
$2^n$
-DISSECTION OF EULER’S PRODUCT
Authors: SARMAH BIPUL KUMAR , GAYAN SATYAJIT 
Published: October 2024

Abstract
Using properties of Ramanujan’s theta functions, we give an elementary proof of Hirschhorn’s conjecture on

$2^n$

-dissection of Euler’s product

$E(q):=(q;q)_\infty $

.
Identifying humpback whale calving grounds: ensemble modelling and spatial analysis of critical habitat in Bahía de Banderas, Mexico
Authors: Noriega Fernando , Lecours Vincent , Frisch-Jordán Astrid , Medrano-González Luis 
Published: October 2024

Abstract
Understanding the relationships between cetaceans and their environment is crucial for conservation. This study examined humpback whales in Bahía de Banderas, Mexico, identifying key calving habitats. From 2018 to 2023, 1066 sightings were recorded, including 242 mother–calf groups, 109 mating groups, and 715 other groups. Spatial analysis revealed a non-random distribution; both the Kruskal–Wallis and Wilcoxon–Mann–Whitney tests detected significant differences (P < 0.05) in site preferences. Calving mothers favoured habitats with a mean depth of 59 m and a distance of 2 km from the coast, while mating groups preferred locations at 126 m and 4 km, and other groups chose areas at 149 m and 4 km. All groups were found in relatively flat areas around 2° seafloor slope. A dispersion test indicated a significant relationship between the location of calving mothers and environmental factors. K-means clustering showed 83.6% of calving mothers' sightings at depths less than 40 m and 2 km from the coast. Ensemble species distribution models identified three critical calving areas: one large area (261.8 km2) along the north coast and two smaller areas (9.5 and 5.4 km2) at the southern end of the bay. This study highlights Bahía de Banderas as a vital breeding habitat for humpback whales, providing insights for conservation strategies to protect calving grounds during the breeding season.
The side effects of a big push growth strategy: export incentives and primary education under military rule in Brazil, 1967–1985
Authors: Kang Thomas H. , Menetrier Isabela , Comim Flavio 
Published: October 2024

Abstract
During the military regime in Brazil (1964–1985), enrollment ratios in primary education grew substantially in the first decade under dictatorship, but stagnated in the mid-1970s. This paper shows that education spending might depend on the levels of centralisation in tax matters. Using panel data regressions and qualitative evidence, we argue that a massive big push industrialisation programme increased the pressure on external accounts, leading the government to intensify an export incentive policy based on tax subsidies that decreased the income of subnational governments. As a result, the capacity of funding mass education was compromised in the second half of the 1970s.
Drivers of human Leptospira infection in the Pacific Islands: A systematic review
Authors: Kharwadkar Sahil , Weinstein Philip , Stanhope Jessica 
Published: October 2024

Abstract
Leptospirosis is a bacterial zoonosis that poses an increasing global public health risk. Pacific Island communities are highly vulnerable to leptospirosis outbreaks, yet the local drivers of infection remain poorly understood. We conducted a systematic review to identify the drivers of human Leptospira infection in the Pacific Islands. There were 42 included studies from which findings were synthesized descriptively. In tropical Pacific Islands, infections were a product of sociodemographic factors such as male gender/sex, age 20 to 60 years, Indigenous ethnicity, and poverty; lifestyle factors such as swimming, gardening, and open skin wounds; and environmental factors, including seasonality, heavy rainfall, and exposure to rodents, cattle, and pigs. Possible mitigation strategies in these islands include strengthening disease reporting standards at a regional level; improving water security, rodent control, and piggery management at a community level; and information campaigns to target individual-level drivers of infection. By contrast, in New Zealand, exposures were predominantly occupational, with infections occurring in meat and farm workers. Accordingly, interventions could include adjustments to occupational practices and promoting the uptake of animal vaccinations. Given the complexity of disease transmission and future challenges posed by climate change, further action is required for leptospirosis control in the Pacific Islands.
Biological properties of vitamin B12
Authors: Moravcová Monika , Siatka Tomáš , Krčmová Lenka Kujovská , Matoušová Kateřina , Mladěnka Přemysl 
Published: October 2024

Abstract
Vitamin B12, cobalamin, is indispensable for humans owing to its participation in two biochemical reactions: the conversion of l-methylmalonyl coenzyme A to succinyl coenzyme A, and the formation of methionine by methylation of homocysteine. Eukaryotes, encompassing plants, fungi, animals and humans, do not synthesise vitamin B12, in contrast to prokaryotes. Humans must consume it in their diet. The most important sources include meat, milk and dairy products, fish, shellfish and eggs. Due to this, vegetarians are at risk to develop a vitamin B12 deficiency and it is recommended that they consume fortified food. Vitamin B12 behaves differently to most vitamins of the B complex in several aspects, e.g. it is more stable, has a very specific mechanism of absorption and is stored in large amounts in the organism. This review summarises all its biological aspects (including its structure and natural sources as well as its stability in food, pharmacokinetics and physiological function) as well as causes, symptoms, diagnosis (with a summary of analytical methods for its measurement), prevention and treatment of its deficiency, and its pharmacological use and potential toxicity.