bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cultivating emotional resilience in adolescent girls: Effects of a growth emotion mindset lesson
Authors: Rudolph Karen D. , Troop‐Gordon Wendy , Skymba Haley V. , Modi Haina H. , Ye Zihua , Clapham Rebekah B. , Dodson Jillian , Finnegan Megan , Heller Wendy 
Published: October 2024

AbstractTo address the widespread mental health crisis facing adolescent girls, this study examined whether a growth emotion mindset lesson can enhance emotional competence. During 2018–2022, adolescent girls (Mage = 15.68 years; 66.3% White) were randomized to a growth mindset (E‐MIND; N = 81) or brain education (control; N = 82) lesson, completed the Trier Social Stressor Test, and reported on various aspects of emotional competence. Compared with the control group, the E‐MIND group reported more adaptive emotion mindsets, higher emotion regulation self‐efficacy, and more proactive in vivo and daily efforts to regulate emotions (effect sizes = small‐to‐medium to medium), with several differences remaining 4‐month later. Findings provide novel insight into one promising approach for cultivating emotional resilience among adolescent girls.
Comparison of patch testing Brazilian (Green) propolis and Chinese (poplar‐type) propolis: Clinical epidemiological study using data from the Information Network of Departments of Dermatology (IVDK)
Authors: Piontek K. , Radonjic‐Hoesli S. , Grabbe J. , Drewitz K. P. , Apfelbacher C. , Wöhrl S. , Simon D. , Lang C. , Schubert S. 
Published: October 2024

AbstractBackgroundPropolis types differ regarding their chemical composition.ObjectivesTo compare patch test results based on Brazilian (Green) propolis with data based on Chinese (poplar‐type) propolis, and to evaluate the specifications of raw materials used for the PT preparations.MethodsIn the Information Network of Departments of Dermatology (IVDK), 1290 consecutive patients were patch tested with Brazilian (Green) propolis (NH400, SmartPractice Europe). Patch test reactivity was compared with results obtained with Chinese (poplar‐type) propolis (NA71, SmartPractice Europe) by calculating frequencies and corresponding 95% confidence intervals. Data on the specifications of raw materials used for NH400 and NA71 were obtained from the manufacturer.ResultsPositive reactions to NH400 were found in 303 (23.5%) patients with unclear clinical relevance in most cases. Patients reacting to NH400 were less often sensitised to fragrances and colophony, but more often to nickel sulphate and cobalt chloride than patients reacting to NA71. The NH400 batch used contained high levels of aerobic bacteria, and was not purified by ethanolic extraction.ConclusionsPattern of concomitant reactivity along with raw material properties suggests that the high frequency of positive reactions to NH400 may primarily result from bacterial contamination or impurities in the PT preparation rather than from propolis constituents.
Physico‐chemical characterisation and light stability of dyes and pigments found in cultural heritage objects: Insights from microfading testing for assessing light fastness
Authors: del Hoyo‐Meléndez Julio M. 
Published: October 2024

AbstractUnderstanding the chemistry of dyes and pigments found in cultural heritage objects and their permanence is central for their preservation. Heritage science research has generally focused on either identification of materials present on actual objects or accelerated and natural ageing of mock‐up samples prepared using historically accurate methods to simulate the materiality of cultural heritage objects. A more recent strategy is the integration of these two research areas, which provides a holistic approach to assess both the chemical composition and stability of materials. Over the last 30 years, microfading testing (MFT) has notably contributed to understanding materials' responsiveness to light, minimising damage to objects from museum lighting and revealing insights into molecular structures of dyes and pigments, when employed in conjunction with other techniques. By combining MFT with diverse analytical methods, including imaging, spectroscopy, microscopy and chromatography, a more comprehensive approach is achieved. This joined‐up strategy contributes to improved decision‐making processes in the conservation and preservation of cultural heritage objects.
Epidemiological Characteristics of Upper Respiratory Tract Pathogens in Children in Guangdong, China
Authors: Zhao Qianwen , Ke Peifeng , Hu Liangshan , Jiang Changhong , Su Rong , Lv Weifeng , Li Qixin , Jiang Lingxiao , Cao Donglin 
Published: October 2024

ABSTRACTObjectiveResearches on the epidemiology of various respiratory pathogens at multiple testing points in the pediatric population are limited, and these are crucial for the prevention of respiratory tract infections in children.MethodsWe obtained 1788 upper respiratory tract swabs from children exhibiting symptoms of respiratory infection (notably fever with a body temperature exceeding 38.5°C) across five hospitals in Guangdong between November 2020 and June 2022. We used the multiplex probe amplification (MPA) PCR testing to identify 11 respiratory viruses and subsequently analyzed the prevalence characteristics of these pathogens among febrile children in hospitals.ResultsThe overall detection rate of the pathogens was 58.1% (1039/1788). Human rhinovirus (HRV) exhibited the highest detection rate at 19.0% (339/1788), succeeded by human parainfluenza virus (HPIV), human adenovirus (HAdV), and respiratory syncytial virus (RSV). The positivity and coinfection rates were higher in children aged 5 years and below compared to those above 5 years. Moreover, a distinct pathogen spectrum was observed across different age groups. Hospitalized patients demonstrated a significantly higher positivity and coinfection rate compared to outpatients. During COVID‐2019, RSV appeared a counter‐seasonal trend.ConclusionRespiratory viral infections in children display distinct characteristics concerning age, hospitalization status, and seasonality. Children under the age of 5 and minor patients admitted to hospitals at least be tested for RSV, HRV, HPIV, and HAdV. The epidemiological patterns of RSV in the post‐epidemic period require ongoing surveillance.
Reexamining Transplant Outcomes in Acute Kidney Injury Kidneys Through Machine Learning
Authors: Jadlowiec Caroline C. , Thongprayoon Charat , Suppadungsuk Supawadee , Tangpanithandee Supawit , Leeaphorn Napat , Heilman Raymond , Cooper Matthew , Cheungpasitporn Wisit 
Published: October 2024

ABSTRACTBackgroundDespite many people awaiting kidney transplant, kidney allografts from acute kidney injury (AKI) donors continue to be underutilized. We aimed to cluster kidney transplant recipients of AKI kidney allografts using an unsupervised machine learning (ML) approach.MethodsUsing Organ Procurement and Transplantation Network–United Network for Organ Sharing (OPTN/UNOS) data, a consensus clustering cohort analysis was performed in 12 356 deceased donor kidney transplant recipients between 2015 and 2019 in whom donors had a terminal serum creatinine ≥1.5 mg/dL. Significant cluster characteristics were determined, and outcomes were compared.ResultsThe median donor terminal creatinine was 2.2 (interquartile range [IQR] 1.7–3.3) mg/dL. Cluster analysis was performed on 12 356 AKI kidney recipients, and three clinically distinct clusters were identified. Young, sensitized kidney re‐transplant patients characterized Cluster 1. Cluster 2 was characterized by first‐time kidney transplant patients with hypertensive and diabetic kidney diseases. Older diabetic recipients characterized Cluster 3. Clusters 1 and 2 donors were young and met standard kidney donor profile index (KDPI) criteria; Cluster 3 donors were older, more likely to have hypertension or diabetes, and meet high KDPI criteria. Cluster 1 had a higher risk of acute rejection, 3‐year patient death, and graft failure. Cluster 3 had a higher risk of death‐censored graft failure, patient death, and graft failure at 1 and 3 years. Cluster 2 had the best patient‐, graft‐, and death‐censored graft survival at 1 and 3 years. Compared to non‐AKI kidney recipients, the AKI clusters showed a higher incidence of delayed graft function (DGF, AKI: 43.2%, 41.7%, 45.3% vs. non‐AKI: 25.5%); however, there were comparable long‐term outcomes specific to death‐censored graft survival (AKI: 93.6%, 93.4%, 90.4% vs. non‐AKI: 92.3%), patient survival (AKI: 89.1%, 93.2%, 84.2% vs. non‐AKI: 91.2%), and overall graft survival (AKI: 84.7%, 88.2%, 79.0% vs. non‐AKI: 86.0%).ConclusionsIn this unsupervised ML approach study, AKI recipient clusters demonstrated differing, but good clinical outcomes, suggesting opportunities for transplant centers to incrementally increase kidney utilization from AKI donors.
Transient Elastography for Noninvasive Evaluation of Posttransplant Liver Graft Fibrosis in Turkish Children, Ege University Children Hospital Experience
Authors: Dogan Barut , Kunay Bora , Umman Veysel , Kıran Taşçı Ezgi , Kumcuoğlu Ziya , Gulbahar Fatih , Nart Deniz , Karakoyun Miray , Cetin Funda , Aydogdu Sema 
Published: October 2024

ABSTRACTObjectivesThe influence of advancing fibrosis on graft survival in the context of pediatric liver transplantation accentuates the critical role of protocol‐driven liver biopsies, a practice adopted by numerous medical centers. Consequently, the exigency for noninvasive methodologies to assess graft fibrosis assumes heightened importance when conventional clinical and laboratory parameters fail to reveal signs of liver damage.MethodsThis study aimed to assess the reliability of transient elastography (TE) in pediatric liver transplant recipients to detect graft fibrosis and compare the results of TE in patients who underwent biopsy.ResultsThis prospective cohort study included liver transplanted children who underwent biopsy at Ege University Children's Hospital between October 1, 2021, and October 31, 2022, and a healthy control group. According to TE, fibrosis was detected in 40 patients, and no fibrosis was detected in 50. The median time to develop fibrosis was 100 months (95% CI [83.1–116.8]). A statistically significant positive correlation existed between LSM and METAVIR fibrosis score (r = 0.562, p = 0.001). There was a statistically significant difference in LSM between patients with F2 fibrosis (7.8–8.8 kPa ± 3.2) compared to patients with F0 fibrosis (5.2 kPa ± 0.7) (p = 0.005) and F1 fibrosis (6.1 kPa ± 1.5) (p = 0.041), on ANOVA.ConclusionLiver allograft fibrosis is common in long‐term follow‐up in children who have undergone liver transplantation. Abnormal TE may guide physicians to consider liver biopsy to detect late allograft fibrosis in these children.
Detecting Cholangiocarcinoma in the Setting of Primary Sclerosing Cholangitis: Is Biliary Tract Fluorescence In Situ Hybridization Helpful?
Authors: Miller Lauren J. , Holmes Isabella M. , Chen‐Yost Heather I. , Smola Brian , Lew Madelyn , Pang Judy 
Published: October 2024

ABSTRACTIntroduction/ObjectiveBiliary brushing cytology (BB) to detect cholangiocarcinoma (CCA) is integral in the surveillance of patients with primary sclerosing cholangitis (PSC). Since reactive changes can mimic carcinoma, indeterminant results are frequent. Fluorescence in situ hybridization (FISH) using the UroVysion probe set has been advocated to enhance the detection of CCA. This study evaluates the performance of FISH for detecting CCA in patients with and without PSC.Materials and MethodsA query of our pathology database for atypical and suspicious BB with concurrent FISH results was performed from 2014 to 2021. FISH (using UroVysion probe set containing centromere enumeration probes to chromosomes 3, 7, and 17) was positive if at least 5 cells demonstrated polysomy. Electronic medical records were reviewed to identify patients with PSC and CCA. CCA was confirmed by pathology or clinical impression.ResultsOf the 65 patients (103 BB) in the PSC cohort, 59 patients (94 BB) without CCA and 6 patients (9 BB) with CCA were identified. 33 non‐PSC patients (41 BB) with CCA were included for comparison. Positive FISH was highest in non‐PSC patients with CCA (10/41 BB, 24%). Positive FISH was seen in both PSC with (1/9 BB, 11%) and without (2/94 BB, 2%) CCA.ConclusionsFISH positivity was lower than expected and was positive in PSC patients without CCA. These results question the clinical utility of FISH for CCA surveillance in PSC patients.
Artificial Intelligence Echocardiography in Resource‐Limited Regions: Applications and Challenges
Authors: Hamza Izhan , Pellikka Patricia A. , Abdulla Amer , Ahmad Masood 
Published: October 2024

ABSTRACTArtificial intelligence (AI) is revolutionizing cardiac imaging, including echocardiography. However, AI has scarce penetration in resource‐limited regions. The implementation of AI‐aided echocardiography (AIE) poses unique challenges and opportunities in resource‐limited areas. Some obvious advantages of AIE include aiding image acquisition, interpretation, and triaging patients based on severity. The challenges AIE faces in resource‐limited regions include a lack of data accessibility for model development, physician apprehension, and an outdated regulatory framework. Based on our early experience with AI, we believe AIE in resource‐limited regions will enhance health equity, improve access to the technology, and lead to cost savings. However, significant efforts are needed to realize these objectives.
Noninvasive Left Ventricular Pressure‐Strain Loop for Quantitative Assessment of Early Left Ventricular Systolic Dysfunction in Patients With Chronic Kidney Disease
Authors: Wang Qin , Wang Jin‐Ping , Li Yan , Zhang Jie , Wang Rui , Xu Hai‐Yun 
Published: October 2024

ABSTRACTBackgroundPatients with chronic kidney disease (CKD) possess a pronounced risk for cardiovascular events. A noninvasive left ventricular pressure‐strain loop (LV‐PSL) has recently been introduced to detect subtler changes in cardiac function. This study aims to investigate the value of LV‐PSL for quantitative assessment of myocardial work (MW) in patients with CKD.MethodsSeventy‐five patients with CKD were enrolled retrospectively (37 patients with CKD Stages 2–3, and 38 patients with CKD Stages 4–5), and 35 healthy volunteers were included as controls. All subjects underwent transthoracic echocardiography. LV‐PSL analysis was performed to estimate LV MW and efficiency. Global work index (GWI), global constructive work (GCW), global wasted work (GWW), and global work efficiency (GWE) were obtained by echocardiography, and the differences among the groups were compared.ResultsThere was a significant increase in GWW and reduction in GWE in patients with CKD compared to normal controls (p < 0.05). No significant difference in GWI and GCW was observed among the three groups. Multiple linear regression revealed that increased GWW was significantly associated with age, serum creatinine, and systolic pressure, and decreased GWE was associated with age, serum creatinine, and GLS.ConclusionLV‐PSL can be used for noninvasive quantitative assessment of MW in patients with CKD, providing a new sensitive approach for the clinical assessment of myocardial function.
Cardiovascular Magnetic Resonance Imaging of Takotsubo Syndrome: Evolving Diagnostic and Prognostic Perspectives
Authors: Cau Riccardo , Masala Salvatore , Manelli Lorenzo , Porcu Michele , Scaglione Mariano , D'Angelo Tommaso , Salgado Rodrigo , Saba Luca 
Published: October 2024

ABSTRACTTakotsubo syndrome (TS) is a temporary form of left ventricular (LV) dysfunction characterized by a distinct pattern of LV impairment, often triggered by a physical or emotional stressful event. Historically, TS was considered a benign condition due to its prompt restoration of myocardial function and generally excellent outcomes. However, recent studies have shown that complications similar to those seen after myocardial infarction can occur, necessitating careful monitoring of these patients. Among noninvasive imaging techniques, cardiovascular magnetic resonance (CMR) is becoming increasingly important in evaluating patients with TS. CMR offers a unique ability to noninvasively assess myocardial tissue characteristics, allowing for detecting the typical features of TS, such as specific wall motion abnormalities and myocardial edema. Beyond its well‐established diagnostic utility in the clinical management of TS, CMR has also proven valuable in prognosis and risk stratification for these patients. Advances in CMR, including myocardial strain and parametric mapping have expanded its role in the diagnosis, prognosis, and follow‐up of these patients. This review aims to provide a comprehensive overview of the potential applications of CMR in the diagnostic and prognostic evaluation of TS patients. It explores the emerging use of novel CMR imaging biomarkers that may enhance diagnosis, improve prognostic accuracy, and contribute to the overall management of these patients.
Cerebral venous thrombosis in elderly patients
Authors: Garcia Victor , Bicart‐Sée Louise , Crassard Isabelle , Legris Nicolas , Zuber Mathieu , Pico Fernando , Guidoux Céline , Obadia Michael , Boulenoir Naouel , Smadja Didier , Mazighi Mikael , Lavenu‐Bombled Cecile , Baudry Elodie , Lapergue Bertrand , Turc Guillaume , Tuppin Philippe , Denier Christian 
Published: October 2024

AbstractBackground and purposeWe aimed to report the characteristics of cerebral venous thrombosis (CVT) in elderly people (aged ≥65 years).MethodsThis multicenter retrospective cohort included elderly patients hospitalized for a first CVT in nine Paris–Ile‐de‐France hospitals between 2011 and 2021. The estimated incidence was compared to CVT recorded by the French health insurance data system. Lariboisière Hospital's CVT registry allowed comparisons of our elderly cohort with individuals younger than 65 years.ResultsOne hundred fourteen patients were included in this study (mean age = 74.2 years, range = 65–93, 61% female). The CVT annual incidence in Ile‐de‐France was 5.9–7.1 per million elderly individuals versus 8.5 per million nationwide. Headaches and focal deficits were the most common initial clinical features (50% and 51%, respectively), followed by seizures and confusion (40% and 27%). Treatment included anticoagulation (93%) and, rarely, endovascular procedure (2%) or craniectomy (1%). Compared with adult patients aged <65 years (younger adults), elderly patients presented fewer headaches (50% vs. 96%, p < 0.01) and intracranial hypertension (7% vs. 22%, p < 0.01) but more seizures and focal deficits (40% vs. 27% and 51% vs. 38%, respectively, p < 0.01). Underlying cancer, hemopathy, and locoregional infections were more frequent in elderly patients than among younger adults (p < 0.01). The prognosis of patients from our elderly cohort was poorer than that of younger adults; 8% died in the acute phase, and 73% had a favorable outcome at 1 year (vs. 1.7% and 87%, respectively, p < 0.01).ConclusionsCVT in elderly patients has a specific clinical presentation, epidemiology, and risk factors such as cancer or hemopathy, justifying specialized management.
Inhibition of Ubiquitin C‐Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF‐β/Smad Signalling Pathway in Fibroblasts
Authors: Pan Huihui , Song Jinru , An Qing , Chen Junyi , Zheng Wenyue , Zhang Litian , Gu Jingjing , Deng Chengcheng , Yang Bin 
Published: October 2024

ABSTRACTUbiquitin C‐terminal hydrolase L1 (UCHL1) plays vital roles in cell proliferation, angiogenesis, inflammation and oxidative stress. Nevertheless, it is unclear whether UCHL1 could regulate the biologic behaviour of cells and ultimately influences wound healing. We aim to illustrate the roles and the underlying mechanism of UCHL1 in cutaneous wound healing. Murine full‐thickness excisional wound model was utilised to study the effects of UCHL1 on wound healing through topical administration of the UCHL1 inhibitor LDN57444, followed by assessment of wound areas and histological alterations. Subsequently, ethynyldeoxyuridine, scratch and transwell assays were performed to examine fibroblast migration and proliferation. The extracellular matrix (ECM)‐related genes expression and transforming growth factor‐β (TGF‐β)/Smad signalling pathways activation were investigated by immuno‐fluorescent staining, Western blots and quantitative reverse transcription polymerase chain reaction. We identified elevated UCHL1 expression in non‐healing wound tissues. The UCHL1 expression displayed a dynamic change and reached a peak on Day‐7 post‐wounding during the healing process in mice. Cutaneous administration of LDN57444 promoted wound healing by facilitating collagen deposition, myofibroblast activation and angiogenesis. In vitro experiments demonstrated that UCHL1 concentration dependently inhibited migration, ECM synthesis and activation of human dermal fibroblasts, which was mechanistically related to downregulation of TGF‐β/Smad signalling. Furthermore, these effects could be reversed by TGF‐β inhibitor SB431542. Our findings reveal that UCHL1 is a negative regulator of cutaneous wound healing and considered as a novel prospective therapeutic target for effective wound healing.
Sliding window based adaptative fuzzy measure for edge detection
Authors: Marco‐Detchart Cedric , Lucca Giancarlo , Santos Silva Miquéias Amorim , Rincon Jaime A. , Julian Vicente , Dimuro Graçaliz 
Published: October 2024

AbstractIn this work, we explore the impact of adaptive fuzzy measures on edge detection, aiming to enhance how computers interpret images by identifying edges more accurately. Traditional methods rely on analysing changes in image brightness to locate edges, but they often use fixed rules that do not account for the unique characteristics of each image. Our approach differs by adjusting fuzzy measures based on the information within specific areas of an image under a sliding window approach, utilizing a variety of fusion functions and generalizations of the Choquet integral to analyse and combine pixel data. The proposed method is flexible, allowing for the adaptation of measures in response to the image's local features. We put our method to the test against the well‐established Canny edge detector to evaluate its effectiveness. Our experimental results suggest that by adapting fuzzy measures for each image section, we can improve edge detection results.
An agent‐based model to simulate the public acceptability of social innovations
Authors: Rodríguez‐Arias Alejandro , Sánchez‐Maroño Noelia , Guijarro‐Berdiñas Bertha , Alonso‐Betanzos Amparo , Lema‐Blanco Isabel , Dumitru Adina 
Published: October 2024

AbstractThe successful adoption of social innovations, such as renewable energy systems or pollution reduction plans in cities, depends, to a large extent, on the willingness and participation of the population in their development and implementation. We present an agent‐based model (ABM) to analyze the process of citizen acceptability of a social innovation that uses a variety of agents to represent individual citizens and relevant groups of citizens. Citizen agents make use of the HUMAT cognitive decision‐making model, based on psychosocial theories, to decide on their support for the social innovation considering how their needs will be satisfied if they decide to support (or not) the innovation project, and the influence exerted by the agents in their environment. The ABM was initially developed to represent the urban and transport planning superblock project in the city of Vitoria‐Gasteiz (Spain). The ABM simulations make it possible to study the evolution of public acceptance of social innovation, with the results providing insights to the social dynamics and individual factors that affect the acceptance of the project, enabling an evaluation of how to devise new policies that increase public acceptance. Sufficiently generic to be easily adaptable to different types of social innovations, the ABM is a powerful tool to explore different scenarios and design strategies that foster the acceptance and sustainable adoption of social innovations.