bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oligogalacturonic Acid Inhibits Vascular Calcification by Two Mechanisms
Authors: Hodroge Ahmed , Trécherel Eric , Cornu Marjorie , Darwiche Walaa , Mansour Ali , Ait-Mohand Katia , Verissimo Thomas , Gomila Cathy , Schembri Carole , Da Nascimento Sophie , Elboutachfaiti Redouan , Boullier Agnès , Lorne Emmanuel , Courtois Josiane , Petit Emmanuel , Toumieux Sylvestre , Kovensky José , Sonnet Pascal , Massy Ziad A. , Kamel Saïd , Rossi Claire , Ausseil Jérôme 
Published: May 2017

Objective—
Cardiovascular diseases constitute the leading cause of mortality worldwide. Calcification of the vessel wall is associated with cardiovascular morbidity and mortality in patients having many diseases, including diabetes mellitus, atherosclerosis, and chronic kidney disease. Vascular calcification is actively regulated by inductive and inhibitory mechanisms (including vascular smooth muscle cell adaptation) and results from an active osteogenic process. During the calcification process, extracellular vesicles (also known as matrix vesicles) released by vascular smooth muscle cells interact with type I collagen and then act as nucleating foci for calcium crystallization. Our primary objective was to identify new, natural molecules that inhibit the vascular calcification process.

Approach and Results—
We have found that oligogalacturonic acids (obtained by the acid hydrolysis of polygalacturonic acid) reduce in vitro inorganic phosphate–induced calcification of vascular smooth muscle cells by 80% and inorganic phosphate–induced calcification of isolated rat aortic rings by 50%. A specific oligogalacturonic acid with a degree of polymerization of 8 (DP8) was found to inhibit the expression of osteogenic markers and, thus, prevent the conversion of vascular smooth muscle cells into osteoblast-like cells. We also evidenced in biochemical and immunofluorescence assays a direct interaction between matrix vesicles and type I collagen via the GFOGER sequence (where single letter amino acid nomenclature is used, O=hydroxyproline) thought to be involved in interactions with several pairs of integrins.

Conclusions—
DP8 inhibits vascular calcification development mainly by inhibition of osteogenic marker expression but also partly by masking the GFOGER sequence—thereby, preventing matrix vesicles from binding to type I collagen.
Deconstruction of Interhospital Transfer Workflow in Large Vessel Occlusion
Authors: Ng Felix C. , Low Essie , Andrew Emily , Smith Karen , Campbell Bruce C.V. , Hand Peter J. , Crompton Douglas E. , Wijeratne Tissa , Dewey Helen M. , Choi Philip M. 
Published: May 2017

Background and Purpose—
Interhospital transfer is a critical component in the treatment of acute anterior circulation large vessel occlusive stroke transferred for mechanical thrombectomy. Real-world data for benchmarking and theoretical modeling are limited. We sought to characterize transfer workflow from primary stroke center (PSC) to comprehensive stroke center after the publication of positive thrombectomy trials.

Methods—
Consecutive patients transferred from 3 high-volume PSCs to a single comprehensive stroke center between January 2015 and August 2016 were included in a retrospective study. Factors associated with key time metrics were analyzed with emphasis on PSC intrahospital workflow.

Results—

Sixty-seven patients were identified. Median age was 74 years (interquartile range [IQR], 63.5–78) and National Institutes of Health Stroke Scale 17 (IQR, 12–21). Median transfer time measured by PSC-door-to-comprehensive stroke center-door was 128 minutes (IQR, 107–164), of which 82.8% was spent at PSCs (door-in-door-out [DIDO]; 106 minutes; IQR, 86–143). The lengthiest component of DIDO was computed-tomography-to-retrieval-request (median 59.5 minutes; IQR, 44–83). The 37.3% had DIDO exceeding 120 minutes. DIDO times differed significantly between PSCs (
P
=0.01). In multivariate analyses, rerecruiting the initial ambulance crew for transfer (
P
<0.01) and presentation during working hours (
P
=0.04) were associated with shorter DIDO times.

Conclusions—
In a metropolitan hub-and-spoke network, PSC-door-to-comprehensive stroke center-door and DIDO times are long even in high-volume PSCs. Improving PSC workflow represents a major opportunity to expedite mechanical thrombectomy and improve patient outcomes.
Turbulence Measurements from Compliant Moorings. Part II: Motion Correction
Authors: Kilcher Levi F. , Thomson Jim , Harding Samuel , Nylund Sven 
Published: May 2017

AbstractAcoustic Doppler velocimeters (ADVs) are a valuable tool for making high-precision measurements of turbulence, and moorings are a convenient and ubiquitous platform for making many kinds of measurements in the ocean. However, because of concerns that mooring motion can contaminate turbulence measurements and that acoustic Doppler profilers make middepth velocity measurements relatively easy, ADVs are not frequently deployed from moorings. This work demonstrates that inertial motion measurements can be used to reduce motion contamination from moored ADV velocity measurements. Three distinct mooring platforms were deployed in a tidal channel with inertial-motion-sensor-equipped ADVs. In each case, motion correction based on the inertial measurements reduces mooring motion contamination of velocity measurements. The spectra from these measurements are consistent with other measurements in tidal channels and have an slope at high frequencies—consistent with Kolmogorov’s theory of isotropic turbulence. Motion correction also improves estimates of cross spectra and Reynolds stresses. A comparison of turbulence dissipation with flow speed and turbulence production indicates a bottom boundary layer production–dissipation balance during ebb and flood that is consistent with the strong tidal forcing at the site. These results indicate that inertial-motion-sensor-equipped ADVs are a valuable new tool for making high-precision turbulence measurements from moorings.
A Machine Learning Approach to Modeling Tropical Cyclone Wind Field Uncertainty
Authors: Loridan Thomas , Crompton Ryan P. , Dubossarsky Eugene 
Published: May 2017

AbstractTropical cyclone (TC) risk assessment models and probabilistic forecasting systems rely on large ensembles to simulate the track trajectories, intensities, and spatial distributions of damaging winds from severe events. Given computational constraints associated with the generation of such ensembles, the representation of TC winds is typically based on very simple parametric formulations. Such models strongly underestimate the full range of TC wind field variability and thus do not allow for accurate representation of the risk profile. With this in mind, this study explores the potential of machine learning algorithms as an alternative to current parametric methods. First, a catalog of high-resolution TC wind simulations is assembled for the western North Pacific using the Weather Research and Forecasting (WRF) Model. The simulated wind fields are then decomposed via principal component analysis (PCA) and a quantile regression forest model is trained to predict the conditional distributions of the first three principal component (PC) weights. With this model, predictions can be made for any quantiles in the distributions of the PC weights thereby providing a way to account for uncertainty in the modeled wind fields. By repeatedly sampling the quantile values, probabilistic maps for the likelihood of attaining given wind speed thresholds can be easily generated. Similarly the inclusion of such a model as part of a TC risk assessment framework can greatly increase the range of wind field patterns sampled, providing a broader view of the threat posed by TC winds.
WMO Assessment of Weather and Climate Mortality Extremes: Lightning, Tropical Cyclones, Tornadoes, and Hail
Authors: Cerveny Randall S. , Bessemoulin Pierre , Burt Christopher C. , Cooper Mary Ann , Cunjie Zhang , Dewan Ashraf , Finch Jonathan , Holle Ronald L. , Kalkstein Laurence , Kruger Andries , Lee Tsz-cheung , Martínez Rodney , Mohapatra M. , Pattanaik D. R. , Peterson Thomas C. , Sheridan Scott , Trewin Blair , Tait Andrew , Wahab M. M. Abdel 
Published: May 2017

AbstractA World Meteorological Organization (WMO) Commission for Climatology international panel was convened to examine and assess the available evidence associated with five weather-related mortality extremes: 1) lightning (indirect), 2) lightning (direct), 3) tropical cyclones, 4) tornadoes, and 5) hail. After recommending for acceptance of only events after 1873 (the formation of the predecessor of the WMO), the committee evaluated and accepted the following mortality extremes: 1) “highest mortality (indirect strike) associated with lightning” as the 469 people killed in a lightning-caused oil tank fire in Dronka, Egypt, on 2 November 1994; 2) “highest mortality directly associated with a single lightning flash” as the lightning flash that killed 21 people in a hut in Manica Tribal Trust Lands, Zimbabwe (at time of incident, eastern Rhodesia), on 23 December 1975; 3) “highest mortality associated with a tropical cyclone” as the Bangladesh (at time of incident, East Pakistan) cyclone of 12–13 November 1970 with an estimated death toll of 300 000 people; 4) “highest mortality associated with a tornado” as the 26 April 1989 tornado that destroyed the Manikganj district, Bangladesh, with an estimated death toll of 1300 individuals; and 5) “highest mortality associated with a hailstorm” as the storm occurring near Moradabad, India, on 30 April 1888 that killed 246 people. These mortality extremes serve to further atmospheric science by giving baseline mortality values for comparison to future weather-related catastrophes and also allow for adjudication of new meteorological information as it becomes available.
Experience of exclusion: A framework analysis of socioeconomic factors affecting cardiac rehabilitation participation among patients with acute coronary syndrome
Authors: Pedersen Maria , Overgaard Dorthe , Andersen Ingelise , Baastrup Marie , Egerod Ingrid 
Published: May 2017

Background: The Danish public healthcare system provides comprehensive care based on the principle of equal access. However, it is well documented that patients with low socioeconomic position are less likely to participate in cardiac rehabilitation. More knowledge is needed to understand this phenomenon. The aim of the study was to explore the patient experience of barriers to completion of phase II cardiac rehabilitation, and to investigate the impact of socioeconomic factors on completion of cardiac rehabilitation. Methods: The study had a qualitative explorative design using semi-structured individual or dyadic interviews with patients ( n = 24) and close relatives ( n = 12). Informants were sampled from a quantitative prospective study of 302 patients with acute coronary syndrome and data were analyzed using the framework method. Results: Patients in different socioeconomic groups were challenged by a rigid and non-individualized rehabilitation program. A total of five themes were identified that might explain non-participation in cardiac rehabilitation: exclusion by time and place, exclusion by health beliefs, exclusion from counseling, exclusion by alienation, and exclusion of relatives. The themes were described in a matrix of socioeconomic factors of age, sex, education and employment. Conclusions: Patients in various socioeconomic subgroups felt excluded from cardiac rehabilitation for different reasons. This study supports earlier findings and provides examples of real-life issues that need to be addressed to prevent attrition and encourage participation. Equal access to cardiac rehabilitation can only be reached if the physical and psychological needs of patient and family are met by tailoring therapy to consider age, sex, education and employment groups.
Can Non-HLA Single Nucleotide Polymorphisms Help Stratify Risk in TrialNet Relatives at Risk for Type 1 Diabetes?
Authors: Steck Andrea K , Xu Ping , Geyer Susan , Redondo Maria J , Antinozzi Peter , Wentworth John M , Sosenko Jay , Onengut-Gumuscu Suna , Chen Wei-Min , Rich Stephen S , Pugliese Alberto ,   the Type 1 Diabetes TrialNet Study Group
Published: May 2017

Abstract

Context
Genome-wide association studies identified &gt;50 type 1 diabetes (T1D) associated non-human leukocyte antigens (non-HLA) loci.

Objective
The purpose of this study was to assess the contribution of non-HLA single nucleotide polymorphisms (SNPs) to risk of disease progression.

Design and Setting
The TrialNet Pathway to Prevention Study follows relatives of T1D patients for development of autoantibodies (Abs) and T1D.

Participants
Using the Immunochip, we analyzed 53 diabetes-associated, non-HLA SNPs in 1016 Ab-positive, at-risk non-Hispanic white relatives.

Main Outcome Measure
Effect of SNPs on the development of multiple Abs and T1D.

Results
Cox proportional analyses included all substantial non-HLA SNPs, HLA genotypes, relationship to proband, sex, age at initial screening, initial Ab type, and number. Factors involved in progression from single to multiple Abs included age at screening, relationship to proband, HLA genotypes, and rs3087243 (cytotoxic T lymphocyte antigen-4). Significant factors for diabetes progression included age at screening, Ab number, HLA genotypes, rs6476839 [GLIS family zinc finger 3 (GLIS3)], and rs3184504 [SH2B adaptor protein 3 (SH2B3)]. When glucose area under the curve (AUC) was included, factors involved in disease progression included glucose AUC, age at screening, Ab number, relationship to proband, HLA genotypes, rs6476839 (GLIS3), and rs7221109 (CCR7). In stratified analyses by age, glucose AUC, age at screening, sibling, HLA genotypes, rs6476839 (GLIS3), and rs4900384 (C14orf64) were significantly associated with progression to diabetes in participants &lt;12 years old, whereas glucose AUC, sibling, rs3184504 (SH2B3), and rs4900384 (C14orf64) were significant in those ≥12.

Conclusions
In conclusion, we identified five non-HLA SNPs associated with increased risk of progression from Ab positivity to disease that may improve risk stratification for prevention trials.
Respiratory function and mechanics in pinnipeds and cetaceans
Authors: Fahlman Andreas , Moore Michael J. , Garcia-Parraga Daniel 
Published: May 2017

ABSTRACTIn this Review, we focus on the functional properties of the respiratory system of pinnipeds and cetaceans, and briefly summarize the underlying anatomy; in doing so, we provide an overview of what is currently known about their respiratory physiology and mechanics. While exposure to high pressure is a common challenge among breath-hold divers, there is a large variation in respiratory anatomy, function and capacity between species – how are these traits adapted to allow the animals to withstand the physiological challenges faced during dives? The ultra-deep diving feats of some marine mammals defy our current understanding of respiratory physiology and lung mechanics. These animals cope daily with lung compression, alveolar collapse, transient hyperoxia and extreme hypoxia. By improving our understanding of respiratory physiology under these conditions, we will be better able to define the physiological constraints imposed on these animals, and how these limitations may affect the survival of marine mammals in a changing environment. Many of the respiratory traits to survive exposure to an extreme environment may inspire novel treatments for a variety of respiratory problems in humans.
El acceso a las TIC en el hogar y en la escuela: su impacto sobre los logros educativos
Authors: Alderete Maria Veronica , Formichella Maria Marta 
Published: May 2017

El objetivo de este trabajo consiste en analizar la incidencia del acceso a las Tecnologías de la Información y de la Comunicación, tanto en el hogar como en la escuela, sobre el rendimiento educativo de los estudiantes de nivel medio. Para ello, se emplean datos del PISA 2012 para la Argentina. De esta manera, mediante el desarrollo de un modelo multinivel, donde la variable dependiente es el rendimiento educativo en la prueba de matemáticas, se encuentra que el acceso a Computadoras e Internet en el hogar y un mayor número de computadoras por estudiante en la escuela influyen positiva y significativamente en el desempeño educativo.
The Identification, Structure, Care, and Conservation of Sawfish Rostra (Rhinopristiformes: Pristidae)
Authors: Byler Jessica 
Published: May 2017

Abstract
Sawfish rostra are commonly found in historic natural science collections, yet there is a scarcity of guidance on their preservation. Rostra are cartilaginous with teeth-like scales. The function and structure of sawfish rostra as well as key mechanical and chemical issues need to be considered for their appropriate care in museum collections. Possible routes of decay are discussed, and methods for the care and conservation of rostra in museum collections are suggested. The species of sawfish can be determined by the morphology of the rostral structure. Physical damage, due to the nature of the material and from handling, often causes deterioration of rostra.
Cutaneous Paraneoplastic Manifestation (Morphea, Lichen Sclerosus) – Two Case Reports
Authors: Pappova T. , Pec J. , Kozarova A. , Adamicova K. 
Published: May 2017

AbstractInternal malignancy may be presented in the form of paraneoplastic syndromes, which may indicate either formation or recurrence of a previously treated malignancy. Furthermore cutaneous paraneoplastic disorders often precede a diagnosis of cancer. We present 2 unique case reports with cutaneous paraneoplastic manifestations. The first one describes a patient with sudden progression of long-term stabilized morphea in connection with newly diagnosed hepatocellular carcinoma (HCC). The second one describes female patient with breast cancer preceded by the development of extragenital lichen sclerosus (LS) with typical sclerotic lesions and hemorrhagic bullae.
Pseudomonas Infection of the Temporomandibular Joint (TMJ) Health and Public Health Issues
Authors: Malachovsky I. , Janickova M. , Stasko J. , Kasaj M. , Sadlonova V. , Novakova E. , Gengelova P. , Smatanová M. , Statelová D. 
Published: May 2017

Abstract
The authors describe a case of a rare infectious disease of intra-articular tissues of the temporomandibular joint caused mainly by Pseudomonas aeruginosa. In scientific literature, under the heading invasive (malignant) external otitis, we can find cases of an infectious disease of the external acoustic meatus caused by a microbial agent of Pseudomonas aeruginosa which can subsequently penetrate into structures. However, a primary affliction of the abovementioned structures has not been described. Localisation and severity of the infection requires long-term and massive treatment with antibiotics.
How to Choose Your Next Top Salesperson: Multiple-Criteria Approach
Authors: Cvetkoska Violeta , Iliev Filip 
Published: May 2017

Abstract
Background: Choosing the most suitable candidate for the position of salesperson is indeed a complex task for managers because several criteria important for the position should be taken into consideration. Such a choice should be considered as a multiple-criteria problem, which can be solved by using the AHP method. Objectives: The main goal is to investigate which criteria are the most important for the managers in the process of selecting a candidate for the position of salesperson, and on that basis to develop an AHP model for ranking of applicant candidates for this position. Methods/Approach: A questionnaire was created, which was sent to 100 sales managers in companies of different industries in Macedonia, in order to grade the importance of the given criteria. Out of the criteria graded, nine that have the highest average grade of importance comprise one of the levels of the AHP model. Results: An average grade of importance for the criteria for choosing a candidate for the position of salesperson is gained, and an AHP model is developed. Conclusions: The developed AHP model is illustrated through a hypothetical example, and its solution serves as a recommendation for who is the best candidate.
Potential, Cultivation and Quality of Some Crambe Sp. in Southern Turkey
Authors: Tansi S. , Karaman Ş. , Tonҫer O. , Ҫömlekҫioğlu N. 
Published: May 2017

Abstract
Crambe sp. is an oilseed crop from the Brassicae family and native to the Mediterranean region. It can be converted into a number of industrial and energy uses. Crambe oil is used in introducing in stain, primers, plastic and solid wax, cosmetic and engine portions in the form of nylon-13.13 exclude carburetor as eco-friendly. All these properties make it interesting. This study is the first report on yield, cultivation procedure, and quality characteristics of Crambe sp. cultivated in Turkey. Native Crambe seeds, collected from eight different locations in Turkey, were cultivated under Çukurova conditions in Mediterranean region. Two Crambe species, Crambe orientalis and Crambe tataria, determined at the locations were studied, and some morphological characteristics and oil compositions were sown from cultivars and native forms. Fatty acid composition of seeds was examined with GC and GC/MS. In native populations, high seed oil contents were obtained from C. tataria (Ankara - Faculty of Science and Letters) and C. tataria (Kahramanmaraş-Elbistan), as 45.62 and 45.50%, respectively. The highest erucic acid content (49.0 %) was found in C. tataria (Ankara-Bilkent). In Çukurova conditions, despite cultivated all collected species, just C. orientalis was bloom among this species, and so that seed yield (472.77 kg/ha) oil rate (% 27.43) and erucic acid (41.0 %) could determine just this species.
Differences in the motor coordination abilities among adolescent gymnasts, swimmers, and ice hockey players
Authors: Jaakkola Timo , Watt Anthony , Kalaja Sami 
Published: May 2017

PurposeMotor coordination is proposed to be a relatively stable age-related construct, unlikely to be influenced by aligned experiential factors such as intensive sport-specific training. The purpose of the study is to investigate if there are differences in motor coordination abilities among young artistic gymnasts, swimmers, and ice hockey players.MethodsThe participants of the study were 508 female and 258 male adolescents (age, <i>M</i> = 12.80, <i>SD</i> = 1.10) comprising artistic gymnasts (<i>n</i> = 463), swimmers (<i>n</i> = 70), and ice hockey players (<i>n</i> = 233). The KTK-test protocol was used to analyse their gross motor coordination abilities.ResultsThe results of the study demonstrated that gymnasts scored better than ice hockey players and swimmers in the test of walking backwards along a beam, and better than ice hockey players in total motor coordination, hopping over an obstacle, and the test of moving sideways on wooden boards. However, ice hockey players scored higher than swimmers and gymnasts in the test of jumping from side to side. Subsequently, swimmers obtained better results in the test of moving sideways on wooden boards as compared with ice hockey players.ConclusionsThe study results indicate that intensive sport-specific training may extend young athletes’ motor coordination characteristics in the ability areas representative of the sport in which they engage.