bluuebunny/crossref_metadata_2025_split huggingface dataset:
Coupled flight dynamics and CFD – demonstration for helicopters in shipborne environment
Authors: Crozon C. , Steijl R. , Barakos G.N. 
Published: November 2017

ABSTRACTThe development of high-performance computing and computational fluid dynamics methods have evolved to the point where it is possible to simulate complete helicopter configurations with good accuracy. Computational fluid dynamics methods have also been applied to problems such as rotor/fuselage and main/tail rotor interactions, performance studies in hover and forward flight, rotor design, and so on. The GOAHEAD project is a good example of a coordinated effort to validate computational fluid dynamics for complex helicopter configurations. Nevertheless, current efforts are limited to steady flight and focus mainly on expanding the edges of the flight envelope. The present work tackles the problem of simulating manoeuvring flight in a computational fluid dynamics environment by integrating a moving grid method and the helicopter flight mechanics solver with computational fluid dynamics. After a discussion of previous works carried out on the subject and a description of the methods used, validation of the computational fluid dynamics for ship airwake flow and rotorcraft flight at low advance ratio are presented. Finally, the results obtained for manoeuvring flight cases are presented and discussed.
Estimating perimeter using graph cuts
Authors: García Trillos Nicolás , Slepčev Dejan , von Brecht James 
Published: November 2017

AbstractWe investigate the estimation of the perimeter of a set by a graph cut of a random geometric graph. For Ω ⊆D= (0, 1)dwithd≥ 2, we are givennrandom independent and identically distributed points onDwhose membership in Ω is known. We consider the sample as a random geometric graph with connection distance ε > 0. We estimate the perimeter of Ω (relative toD) by the, appropriately rescaled, graph cut between the vertices in Ω and the vertices inD∖ Ω. We obtain bias and variance estimates on the error, which are optimal in scaling with respect tonand ε. We consider two scaling regimes: the dense (when the average degree of the vertices goes to ∞) and the sparse one (when the degree goes to 0). In the dense regime, there is a crossover in the nature of the approximation at dimensiond= 5: we show that in low dimensionsd= 2, 3, 4 one can obtain confidence intervals for the approximation error, while in higher dimensions one can obtain only error estimates for testing the hypothesis that the perimeter is less than a given number.
Uniform convergence over time of a nested particle filtering scheme for recursive parameter estimation in state-space Markov models
Authors: Crisan Dan , Míguez Joaquín 
Published: November 2017

AbstractWe analyse the performance of a recursive Monte Carlo method for the Bayesian estimation of the static parameters of a discrete-time state-space Markov model. The algorithm employs two layers of particle filters to approximate the posterior probability distribution of the model parameters. In particular, the first layer yields an empirical distribution of samples on the parameter space, while the filters in the second layer are auxiliary devices to approximate the (analytically intractable) likelihood of the parameters. This approach relates the novel algorithm to the recent sequential Monte Carlo square method, which provides anonrecursivesolution to the same problem. In this paper we investigate the approximation of integrals of real bounded functions with respect to the posterior distribution of the system parameters. Under assumptions related to the compactness of the parameter support and the stability and continuity of the sequence of posterior distributions for the state-space model, we prove that theLpnorms of the approximation errors vanish asymptotically (as the number of Monte Carlo samples generated by the algorithm increases) and uniformly over time. We also prove that, under the same assumptions, the proposed scheme can asymptotically identify the parameter values for a class of models. We conclude the paper with a numerical example that illustrates the uniform convergence results by exploring the accuracy and stability of the proposed algorithm operating with long sequences of observations.
Fluid limit for the Poisson encounter-mating model
Authors: Gün Onur , Yilmaz Atilla 
Published: November 2017

Abstract
Stochastic encounter-mating (SEM) models describe monogamous permanent pair formation in finite zoological populations of multitype females and males. In this paper we study SEM models with Poisson firing times. First, we prove that the model enjoys a fluid limit as the population size diverges, that is, the stochastic dynamics converges to a deterministic system governed by coupled ordinary differential equations (ODEs). Then we convert these ODEs to the well-known Lotka–Volterra and replicator equations from population dynamics. Next, under the so-called fine balance condition which characterizes panmixia, we solve the corresponding replicator equations and give an exact expression for the fluid limit. Finally, we consider the case with two types of female and male. Without the fine balance assumption, but under certain symmetry conditions, we give an explicit formula for the limiting mating pattern, and then use it to characterize assortative mating.
Asymptotic failure rates for a general class of frailty models
Authors: Gupta Ramesh C. , Bradley David M. 
Published: November 2017

Abstract
We elucidate the long-term behavior of failure rates for a broad class of frailty models in survival analysis. The class properly includes the proportional hazard frailty model, the additive frailty model, and the accelerated failure time frailty model. A complete asymptotic expansion is derived and compared with the corresponding result for the limiting behavior obtained by Finkelstein and Esaulova (2006a). Several examples are provided to facilitate the comparison and to illustrate both the applicability and the limitations of our approach.
COST OF CURE DAMAGES AND THE RELEVANCE OF THE INJURED PROMISEE'S INTENTION TO CURE
Authors: Rowan Solène 
Published: November 2017

AbstractThe article focuses on whether, when considering whether to award cost of cure damages, the courts take account of what the injured promisee to a breach of contract does, or intends to do, with his damages award, and whether or not they should take account of it. This issue has given rise to divergent approaches and some confusion in the cases. The article seeks to shed new light on the issue and considers possible ways of resolving the confusion.
THE “UNITARY EXERCISE” OF CONTRACTUAL INTERPRETATION
Authors: Havelock Rohan 
Published: November 2017

LORD Hoffmann's famous “restatement” of the principles of contractual interpretation in Investors Compensation Scheme v West Bromwich Building Society [1998] 1 W.L.R. 896, 912–13, was heralded as a “quiet revolution” (McLauchlan (2000) 19 N.Z.U.L.R. 147, at 148) in that it appeared to overthrow the legalistic approach of the past. That approach, often associated with the “plain meaning rule” (Bank of New Zealand v Simpson [1990] A.C. 182 (PC), 189) involved giving effect to the expressed meaning of the text, which (limited exceptions aside) could not be contradicted by the relevant background (or matrix of fact). By contrast, the approach in ICS mandated the Court to search for the apparently intended meaning by consulting the relevant and admissible background in all cases. The ICS approach rapidly became dominant, and indeed orthodox, across multiple jurisdictions. However, in a series of judgments commencing with Re Sigma Finance Corporation [2009] UKSC 2; [2010] 1 All E.R. 571, the Supreme Court of the United Kingdom has gradually moved away from the approach in ICS (albeit without expressly overruling it) and emphasised the importance of giving effect to the natural and ordinary meaning of the words used, in combination with other factors (see especially Marley v Rawlings [2014] UKSC 2; [2014] 2 W.L.R. 213, at [18]–[19]; Arnold v Britton [2015] UKSC 36; [2015] A.C. 1619, at [14]–[23]). This return to a more traditional approach to interpretation vindicates sustained criticism of the validity of the ICS approach in principle and practice (see e.g. Staughton [1999] C.L.J. 303; Berg (2006) 122 L.Q.R. 354; Buxton [2010] C.L.J. 253).
AGRO-ECOSYSTEM SERVICES ASSESSMENT OF SILVOPASTORAL EXPERIENCES IN CHIAPAS, MEXICO: TOWARDS A METHODOLOGICAL PROPOSAL
Authors: MARINIDOU ELENI , JIMÉNEZ-FERRER GUILLERMO , SOTO-PINTO LORENA , FERGUSON BRUCE G. , SALDÍVAR-MORENO ANTONIO 
Published: November 2017

SUMMARYIn response to the current needs of humanity with regard to food production, environmental disasters and climate change, it is important to define (livestock) production systems and management practices that are both productive and ecologically sustainable. We qualitatively assessed advanced silvopastoral experiences in five ecologically and culturally distinct regions in Chiapas, Mexico, given their ability to provide key services: internal (productivity and productive resiliency) and external (climate change mitigation and biodiversity conservation). We propose 20 indicators that reflect management, resources, use of external inputs, availability of food, commercial products and animal feed and trees in grazing and forest areas. Sets of some indicators form criteria for dependence on external inputs, productive diversification with emphasis on food security, soil conservation, tree cover and landscape connectivity, among others. Indicators and thresholds were adjusted to critical (traffic light) levels, based on field data. Comparing the levels reached by the studied experiences, we found that most of the resulting services go hand in hand; so ‘win–win’ situations are possible to be achieved. The elements and practices that affect both internal and external services were explored. The red light critical points in each production unit were identified so that they could be attended. Experiences that presented higher levels in assessment criteria could serve as examples to enable the improvement of livestock systems under similar conditions. We propose this assessment as a tool for rapid intervention that can be widely applied to livestock systems, from conventional to organic or diversified, because of the criteria used. However, it can be more flexible, as new criteria can be added and thresholds can be adjusted for other types of production systems, always reflecting local and desired conditions. The proposed indicators can be also used as a basis for a quantitative agroecosystem assessment.
Monorchis lewisi n. sp. (Trematoda: Monorchiidae) from the surf bream, Acanthopagrus australis (Sparidae), in Moreton Bay, Australia
Authors: Cribb T.H. , Wee N.Q.-X. , Bray R.A. , Cutmore S.C. 
Published: November 2017

AbstractWe describe Monorchis lewisi n. sp. (Monorchiidae) from the surf bream, Acanthopagrus australis (Günther, 1859) (Sparidae), in Moreton Bay, eastern Australia. The new species differs from most existing species of Monorchis Monticelli, 1893 in its possession of an elongate I-shaped excretory vesicle, and from other congeners in the relative configuration of the gut and suckers. Ovipusillus mayu Dove & Cribb, 1998 is re-reported from Gnathanodon speciosus (Forsskål, 1775) (Carangidae) from Moreton Bay. We report new second internal transcribed spacer (ITS2) and 28S rDNA sequence data for both species. Bayesian inference and Maximum Likelihood analyses of the 28S rDNA dataset suggest that existing subfamily and genus concepts within the family require substantial revision.
Keeping it simple: the grammatical properties of shared book reading
Authors: NOBLE Claire H. , CAMERON-FAULKNER Thea , LIEVEN Elena 
Published: November 2017

AbstractThe positive effects of shared book reading on vocabulary and reading development are well attested (e.g., Bus, van Ijzendoorn, & Pellegrini, 1995). However, the role of shared book reading in grammatical development remains unclear. In this study, we conducted a construction-based analysis of caregivers’ child-directed speech during shared book reading and toy play and compared the grammatical profile of the child-directed speech generated during the two activities. The findings indicate that (a) the child-directed speech generated by shared book reading contains significantly more grammatically rich constructions than child-directed speech generated by toy play, and (b) the grammatical profile of the book itself affects the grammatical profile of the child-directed speech generated by shared book reading.
High-temperature stress during drying improves subsequent rice (Oryza sativa L.) seed longevity
Authors: Whitehouse Katherine J. , Hay Fiona R. , Ellis Richard H. 
Published: November 2017

AbstractPost-harvest drying prolongs seed survival in air-dry storage; previous research has shown a benefit of drying moist rice seeds at temperatures greater than recommended for genebanks (5–20°C). The aim of this study was to determine whether there is a temperature limit for safely drying rice seeds, and to explore whether the benefit to longevity is caused by high-temperature stress or continued seed development. Seeds of two rice varieties were harvested at different stages of development and dried initially either over silica gel, or intermittently (8 h day–1) or continuously (24 h day–1) over MgCl2 at temperatures between 15 and 60°C for up to 3 days. Seeds dried more rapidly the warmer the temperature. Subsequent seed longevity in hermetic storage (45°C and 10.9% moisture content) was substantially improved by increase in drying temperature up to 45°C in both cultivars, and also with further increase from 45 to 60°C in cv. ‘Macassane’. The benefit of high-temperature drying to subsequent longevity tended to diminish the later the stage of development at seed harvest. Intermittent or continuous drying at high temperatures provided broadly similar improvements to longevity, but with the greatest improvements detected in a few treatment combinations with continuous drying. Heated-air drying of rice seeds harvested before maturity improved their subsequent storage longevity by more than that which occurred during subsequent development in planta, which may have resulted from the triggering of protection mechanisms in response to high-temperature stress.
RACE, CRIMINAL INJUSTICE FRAMES, AND THE LEGITIMATION OF CARCERAL INEQUALITY AS A SOCIAL PROBLEM
Authors: Pickett Justin T. , Ryon Stephanie Bontrager 
Published: November 2017

AbstractMichelle Alexander argues that carceral inequality and mass incarceration together have created a “new racial caste system” in America (2010, p. 11). She contends that only a race-conscioussocial movement that engages both legal actors and the public can dismantle this system of racial control. Unfortunately, very little research has examined views about carceral inequality. Little is known about the attitudes of juvenile and criminal justice workers. We build on and integrate three literatures—scholarship on the framing perspective, comparative conflict theory, and group position theory and racial ideology—to develop a theoretical model of attitudes toward carceral inequality. We hypothesize that race influences the resonance of attributional frames, especially criminal injustice frames, but endorsement of these frames represents the primary factor shaping judgments about whether carceral inequality is a social problem (propriety, urgency, severity and policy frames). For several decades, framing efforts have been underway aimed at mobilizing JCJW to reduce racial disparities in the juvenile justice system. And most offenders first have contact with the state as juveniles. Accordingly, to test our theory, we analyze data on views about carceral inequality in the juvenile justice system—or disproportionate minority contact—among a nationwide sample of justice workers (N = 543). The findings show that race is strongly associated with attributional frames about carceral inequality, and is indirectly related, through attributional frames, to endorsement of propriety, urgency, severity, and policy frames about carceral inequality.
Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma
Authors: Lauss Martin , Donia Marco , Harbst Katja , Andersen Rikke , Mitra Shamik , Rosengren Frida , Salim Maryem , Vallon-Christersson Johan , Törngren Therese , Kvist Anders , Ringnér Markus , Svane Inge Marie , Jönsson Göran 
Published: November 2017

AbstractAdoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical trials in melanoma; however, 50–60% of the patients have no clinical benefit. Here, we searched for predictive biomarkers to ACT in melanoma. Whole exome- and transcriptome sequencing and neoantigen prediction were applied to pre-treatment samples from 27 patients recruited to a clinical phase I/II trial of ACT in stage IV melanoma. All patients had previously progressed on other immunotherapies. We report that clinical benefit is associated with significantly higher predicted neoantigen load. High mutation and predicted neoantigen load are significantly associated with improved progression-free and overall survival. Further, clinical benefit is associated with the expression of immune activation signatures including a high MHC-I antigen processing and presentation score. These results improve our understanding of mechanisms behind clinical benefit of ACT in melanoma.
Fusion guide RNAs for orthogonal gene manipulation with Cas9 and Cpf1
Authors: Kweon Jiyeon , Jang An-Hee , Kim Da-eun , Yang Jin Wook , Yoon Mijung , Rim Shin Ha , Kim Jin-Soo , Kim Yongsub 
Published: November 2017

AbstractThe bacteria-derived clustered regularly interspaced short palindromic repeat (CRISPR)–Cas systems are powerful tools for genome engineering. Recently, in addition to Cas protein engineering, the improvement of guide RNAs are also performed, contributing to broadening the research area of CRISPR–Cas9 systems. Here we develop a fusion guide RNA (fgRNA) that functions with both Cas9 and Cpf1 proteins to induce mutations in human cells. Furthermore, we demonstrate that fgRNAs can be used in multiplex genome editing and orthogonal genome manipulation with two types of Cas proteins. Our results show that fgRNAs can be used as a tool for performing multiple gene manipulations.
Heme enables proper positioning of Drosha and DGCR8 on primary microRNAs
Authors: Partin Alexander C. , Ngo Tri D. , Herrell Emily , Jeong Byung-Cheon , Hon Gary , Nam Yunsun 
Published: November 2017

AbstractMicroRNAs regulate the expression of many proteins and require specific maturation steps. Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing the RNase Drosha and its partner protein, DGCR8. Although DGCR8 is known to bind heme, the molecular role of heme in pri-miR processing is unknown. Here we show that heme is critical for Microprocessor to process pri-miRs with high fidelity. Furthermore, the degree of inherent heme dependence varies for different pri-miRs. Heme-dependent pri-miRs fail to properly recruit Drosha, but heme-bound DGCR8 can correct erroneous binding events. Rather than changing the oligomerization state, heme induces a conformational change in DGCR8. Finally, we demonstrate that heme activates DGCR8 to recognize pri-miRs by specifically binding the terminal loop near the 3′ single-stranded segment.
Generation of interspecies limited chimeric nephrons using a conditional nephron progenitor cell replacement system
Authors: Yamanaka S. , Tajiri S. , Fujimoto T. , Matsumoto K. , Fukunaga S. , Kim B. S. , Okano H. J. , Yokoo T. 
Published: November 2017

AbstractAnimal fetuses and embryos may have applications in the generation of human organs. Progenitor cells may be an appropriate cell source for regenerative organs because of their safety and availability. However, regenerative organs derived from exogenous lineage progenitors in developing animal fetuses have not yet been obtained. Here, we established a combination system through which donor cells could be precisely injected into the nephrogenic zone and native nephron progenitor cells (NPCs) could be eliminated in a time- and tissue-specific manner. We successfully achieved removal of Six2+ NPCs within the nephrogenic niche and complete replacement of transplanted NPCs with donor cells. These NPCs developed into mature glomeruli and renal tubules, and blood flow was observed following transplantation in vivo. Furthermore, this artificial nephron could be obtained using NPCs from different species. Thus, this technique enables in vivo differentiation from progenitor cells into nephrons, providing insights into nephrogenesis and organ regeneration.
Daily Time-Use Patterns and Obesity and Mental Health among Primary School Students in Shanghai: A Population-Based Cross-Sectional Study
Authors: Zhang Yunting , Zhang Donglan , Li Xinyue , Ip Patrick , Ho Frederick , Jiang Yanrui , Sun Wanqi , Zhu Qi , Zhu Weiming , Zhang Jun , Zhao Hongyu , Wang Guanghai , Shen Xiaoming , Jiang Fan 
Published: November 2017

AbstractPhysical activity, screen viewing, sleep, and homework among children have been independently linked to health outcomes. However, few studies have assessed the independent associations between time spent in daily activities and children’s physical and mental health. This study describes time spent in four activities among primary school students in Shanghai, and examines the relationship between daily time-use patterns and obesity and mental health. The representative sample consists of 17,318 children aged 6–11 years in Shanghai. Time spent in moderate to vigorous physical activities (MVPA), screen viewing, sleep, and homework was measured by validated questionnaires. Logistic regressions were performed. We also fitted generalized additive models (GAM) and performed two-objective optimization to minimize the probability of poor mental health and obesity. In 2014, 33.7% of children spent ˂1 hour/day on MVPA, 15.6% spent ≥ 2 hours/day on screen viewing, 12.4% spent ˂ 9 hours/day on sleep, and 27.2% spent ≥ 2 hours/day on homework. The optimization results suggest that considering the 24-hour time limit, children face trade-offs when allocating time. A priority should be given to the duration of sleep and MVPA. Screen exposure should be minimized to save more time for sleep and other beneficial activities.