bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengembangan Kawasan Pariwisata dalam Upaya Meningkatkan Kesejahteraan Masyarakat di Provinsi Nusa Tenggara Barat
Authors: Kuswandi Aos , Purwatih Adlin Resa , Nuraini Siti 
Published: September 2024

Provinsi Nusa Tenggara Barat merupakan provinsi yang dianggap berhasil dalam meningkatkan kesejahteraan masyarakatnya melalui destinasi pariwisata. Pada Penelitian ini bertujuan untuk menganalisis pengembangan kawasan pariwisata sebagai destinasi wisata unggulan dalam upaya meningkatkan kesejahteraan masyarakat di Provinsi Nusa Tenggara Barat. Analisis kesejahteraan sosial, pengembangan pariwisata, dan konsep destinasi wisata, merupakan konsep teeori yang dipergunakan. Penelitian dilakukan dengan pendekatan deskriptif analisis dengan metode studi literatur dengan melakukan pengumpulan data yang diperoleh dari data sekunder. Penelitian ini mengambil lokasi di Nusa Tenggara Barat yang merupakan salah satu provinsi di Indonesia yang mampu mencapai keberhasilan dalam meningkatkan kesejahteraan masyarakatnya melalui pengembangan pariwisata. Hasil analisis menunjukkan bahwa Provinsi Nusa Tenggara Barat mampu mencapai tujuan pemerintahan meningkatkan kesejahteraan masyaraka. Faktor utama keberhasilan tersebut didukung oleh peran pemerintah daerah Provinsi Nusa Tenggara Barat. Kesejahteraan masyarakat di Provinsi Nusa Tenggara Barat sudah mencapai taraf hidup yang baik dengan tersedianya lapangan kerja, dan terciptanya kemitraan antara pemerintah daerah, swasta dan masyarakat (good governance). Provinsi Nusa Tenggara Barat melalui pengembangan destinasi pariwisata unggulan mampu meningkatkan penerimaan pendapatan daerah yang tinggi.
The influence of Helicobacter pylori infection on acute coronary syndrome and lipid metabolism in the Chinese ethnicity
Authors: Fang Yizhen , Fan Chunming , Li Yun , Xie Huabin 
Published: September 2024

BackgroundAcute coronary syndrome (ACS) patients frequently present a relatively high prevalence of Helicobacter pylori (H. pylori) infection. H. pylori was previously hypothesized to induce ACS through the regulation of lipid levels. However, the risk of H. pylori-induced ACS varies significantly among different ethnic groups, and the associations between H. pylori and lipid parameters remain unclear. This study aimed to systematically assess the risk of ACS in Chinese populations with H. pylori infection while also evaluating the effects of H. pylori on lipid parameters.Materials and methodsA hospital-based case−control study involving 280 participants was conducted. Immunoblotting was used for the detection and genotyping of H. pylori. The associations between H. pylori and ACS, as well as lipid parameters, were analyzed via the chi-square test and a multiple logistic regression model.ResultsH. pylori infection significantly increased the risk of ACS among all participants (adjusted odds ratio (OR) = 4.04, 95% confidence interval (CI): 1.76−9.25, P &lt; 0.05), with no associations with virulence factors (cytotoxin-associated gene A (CagA) or vacuole toxin geneA (VacA)). Subgroup analysis revealed a significant increase in the risk of ACS among the elderly population aged 56−64 years with H. pylori infection. Additionally, a substantial association was observed between H. pylori and acute myocardial infarction (AMI). No significant differences were found in lipid parameters, including low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and the LDL/HDL ratio, between individuals positive and negative for H. pylori infection. Similar results were observed between the ACS group and the control group.ConclusionsOur study has demonstrated for the first time that H. pylori does not significantly impact lipid metabolism but increases the risk of ACS fourfold in the Chinese population (OR = 4.04, 95% CI: 1.76−9.25). Furthermore, the virulence factors of H. pylori (CagA and VacA) may not be involved in the mechanisms by which they promote the development of ACS. This finding provides additional evidence for the association between H. pylori and ACS among different ethnic groups and refutes the biological mechanism by which H. pylori affects ACS through lipid metabolism regulation. Regular screening for H. pylori and eradication treatment in elderly individuals and those at high risk for ACS may be effective measures for reducing the incidence of ACS. Future research should include multicenter randomized controlled trials and explore host genetics and the effects of H. pylori on the gut microbiota as potential biological pathways linking H. pylori and ACS.
Women of reproductive age's use of maternal healthcare services and associated factors in Liben district, East Borena zone, Oromia Regional State, Ethiopia
Authors: Desta Mekonnen , Mengistu Serawit , Arero Godana 
Published: September 2024

BackgroundOne of the most important health interventions for reducing maternal morbidity and death is the use of maternal healthcare services. In Ethiopia, maternal healthcare services are not well utilized, particularly in rural pastoralist communities, despite their significance. Therefore, the purpose of this study was to evaluate the use of maternal healthcare services and the characteristics that are related to it in the East Borena zone. Techniques: In September 2020, a community-based cross-sectional survey was carried out in Liben with 416 randomly selected mothers. Mothers who had given birth within the 12 months before the study comprised the respondents. Questionnaires given by interviewers were used to gather the data. The data were transferred to SPSS version 20 for analysis after being entered into Epi-Info version 4.1 for coding. The Kolmogorov-Smirnov, Hosmer, and Lemeshow goodness of fit tests were employed, along with descriptive statistics. Additionally, multivariate and binary logistic regression analyses were carried out. 95% CI and the odd ratio were used to examine the relationship between the outcome and predictive variables.ResultsAt least one prenatal visit was received by 60% of moms. Only 21.2% and 17.5% of women had given birth in a medical facility and made use of early postnatal care services. The use of antenatal care was strongly correlated with maternal education [AOR = 2.43 (95% CI: 1.22–4.89)], decision-making capability [AOR = 2.40 (95% CI: 1.3–23.3)], felt compassionate and respectful treatment [AOR = 0.30 (95% CI: 0.18–0.50)], and intended current pregnancy [AOR = 0.22 (95% CI: 0.12–0.37)]. Moms b/n ages 15–19 had a 3.7-fold higher probability of giving birth in a hospitals than moms b/n ages 35 and 49 [AOR = 1.74 (95% CI: 1.02–3.08)]. Mothers who lived far away were 1.02 times less likely to give birth at a hospital than those who could reach one within an hour (AOR = 1.74;95% CI: 1.02, 3.08). While recent use of antenatal care [AOR = 5.34 (95% CI: 1.96–8.65)], planned current pregnancy, and knowledge of using postnatal care were shown to be strongly correlated with danger indicators [AOR = 2.93 (95% CI: 1.59–5.41)], knowledge of danger signs [AOR = 3.77 (95% CI: 2.16–6.57)] and perceived compassionate and respectful care were significantly associated with institutional delivery.ConclusionOverall the prevalence of maternal healthcare services utilization was far below the national and regional targets in the study area. Thus, promoting institutional services, raising community knowledge, empowering women to make decisions, and enhancing the infrastructure of the health sector.
Evaluating the implementation fidelity of basic emergency obstetrics and neonatal care services in Beyeda District, Northwest Ethiopia: a case study evaluation
Authors: Ejigu Hawltu Abeyu , Yazachew Lake , Amare Getasew , Tsehay Chalie Tadie , Hagos Asebe , Tafere Tesfahun Zemene 
Published: September 2024

BackgroundWorldwide, nearly 830 women die from complications of pregnancy and childbirth daily. Ninety-nine per cent of these maternal deaths take place in low and middle-income countries. Basic Emergency Obstetric Care (BEmONC) is one method of reducing maternal mortality related to pregnancy and childbirth complications. However, the status of its implementation fidelity has not been investigated. Therefore, this study sought to evaluate the implementation fidelity of BEmONC services in Beyeda District, Northwest Ethiopia.Evaluation methodsA single case study design with mixed method was employed from June 01 to July 30, 2022. 415 client exit interviews, 14 key informants’ interviews and 423 retrospective document reviews were conducted. Adherence, participant responsiveness and quality of delivery dimensions from Carroll's conceptual framework, with a total of 21 indicators were used in this evaluation. The overall implementation fidelity status of BEmONC service was judged based on the pre-seated judgmental criteria as; low, medium, and high fidelity.ResultsThe overall degree of implementation fidelity of the BEmONC services was 74.5%. Moreover, the implementation fidelity status of adherence, quality of delivery, and participant responsiveness dimensions were 74.7%, 77.2%, and 71.5% respectively. Uterotonic drugs were not administered as per the recommended protocol. Participants’ engagement towards the neonatal resuscitation service delivery was inadequate. Likewise, healthcare providers’ respect for the clients was not sufficient. Furthermore, women aged &gt;30 years, being government employed and ANC visits four and above were variables positively associated with the quality of delivery of BEmONC services.ConclusionThe overall implementation fidelity of the BEmONC services was judged as implemented in medium fidelity. Moreover, the adherence, participant responsiveness and quality of delivery dimensions were found to be implemented in medium fidelity. Therefore, public health sectors at all levels should strive to enhance the implementation fidelity of BEmONC services. Moreover, healthcare providers should adhere to the BEmONC implementation protocol guideline during service delivery. Healthcare managers should facilitate a continuous awareness creation for mothers regarding the merit of neonatal resuscitation for neonatal complications. Furthermore, healthcare providers should give due respect to mothers while delivering the services.
Deciphering colorectal cancer radioresistance and immune microrenvironment: unraveling the role of EIF5A through single-cell RNA sequencing and machine learning
Authors: Zhong Yaqi , Chen Xingte , Wu Shiji , Fang Huipeng , Hong Liang , Shao Lingdong , Wang Lei , Wu Junxin 
Published: September 2024

BackgroundRadiotherapy (RT) is a critical component of treatment for locally advanced rectal cancer (LARC), though patient response varies significantly. The variability in treatment outcomes is partly due to the resistance conferred by cancer stem cells (CSCs) and tumor immune microenvironment (TiME). This study investigates the role of EIF5A in radiotherapy response and its impact on the CSCs and TiME.MethodsPredictive models for preoperative radiotherapy (preRT) response were developed using machine learning, identifying EIF5A as a key gene associated with radioresistance. EIF5A expression was analyzed via bulk RNA-seq and single-cell RNA-seq (scRNA-seq). Functional assays and in vivo experiments validated EIF5A’s role in radioresistance and TiME modulation.ResultsEIF5A was significantly upregulated in radioresistant colorectal cancer (CRC) tissues. EIF5A knockdown in CRC cell lines reduced cell viability, migration, and invasion after radiation, and increased radiation-induced apoptosis. Mechanistically, EIF5A promoted cancer stem cell (CSC) characteristics through the Hedgehog signaling pathway. Analysis of the TiME revealed that the radiation-resistant group had an immune-desert phenotype, characterized by low immune cell infiltration. In vivo experiments showed that EIF5A knockdown led to increased infiltration of CD8+ T cells and M1 macrophages, and decreased M2 macrophages and Tregs following radiation therapy, thereby enhancing the radiotherapy response.ConclusionEIF5A contributes to CRC radioresistance by promoting CSC traits via the Hedgehog pathway and modulating the TiME to an immune-suppressive state. Targeting EIF5A could enhance radiation sensitivity and improve immune responses, offering a potential therapeutic strategy to optimize radiotherapy outcomes in CRC patients.
Seasonal biophysical interactions in tidal marsh evolution: insights from a synchronized dataset in Jiangsu, China
Authors: Chen Lei , Moeller Iris , Zhou Zeng , Hu Zhan , Zhang Yanan , Chu Mengwei , Jia Yifei , Townend Ian , Zhang Changkuan 
Published: September 2024

IntroductionTidal marsh wetlands provide essential and valuable services to the wider interconnected marine and coastal environment, although the complex intertwined processes in morphological evolution remain insufficiently understood owing to synchronized data scarcity, limiting the development of numerical models and management strategies.MethodsThis study investigated the hydrodynamic, biological, sediment and morphological processes on the Doulong tidal wetlands, Jiangsu, China, using a one-year field dataset that captured spatial and seasonal variations.Results and discussionOur results indicate that biophysical interactions among multiple processes could result in some overlooked sedimentary behaviours and bio-morphological patterns in tidal marsh wetlands. Firstly, the dominance of alongshore currents caused a rapid alongshore expansion of saltmarsh patches, by which the marsh edge achieved seaward advancing, markedly different from the widely reported cross-shore expansion. Secondly, results showed that the particle size of sediment near the marsh edge coarsened when plants withered and then fined when plants grew, indicating that the seasonal variation trend of sediment grain size in saltmarshes was opposite to the trend of vegetation biomass. Thirdly, the interaction between vegetation and stranded marine debris formed banded debris zones within the saltmarsh, where debris bands could cause a biomass reduction of up to 58%, disrupting the commonly-observed parabolic biomass-elevation relationship. Meanwhile, the seasonal variation of vegetation and hydrodynamics could alter the debris positions and hence result in the formation of multiple parallel debris bands. Overall, this study provides a synchronized dataset and elucidates specific bio-morphological relationships and processes that have thus far not been systematically documented, enhancing the comprehensive understanding of tidal marsh wetland evolution.
To explore the postoperative nutritional status and factors influencing prognosis in patients with chronic constipation complicated by malnutrition
Authors: Wang Le , Tian Hongliang , Li Long , Ye Chen , Cui Jiaqu , Lin Zhiliang , Yang Bo , Zhao Di , Li Ning , Feng Xiaobo , Chen Qiyi 
Published: September 2024

BackgroundMany patients with constipation also suffer from varying degrees of malnutrition, and the relationship between the two conditions is a vicious cycle. Surgery is the final step in the treatment of constipation, with a success rate of up to 95%. This study aims to investigate the effects of surgical treatment on the nutritional status of patients with chronic constipation and malnutrition.MethodsA total of 60 patients with chronic constipation and various degrees of malnutrition who underwent surgery in our department from January 2020 to March 2023 were included in this study. Biochemical tests including BMI, albumin, total protein, hemoglobin, cholesterol and lymphocyte count were conducted, as well as measurements of inflammatory markers such as Interleukin-6 (IL-6), Interleukin-8 (IL-8), and C-reactive protein (CRP). Additionally, multiple nutritional risk screening scales (NRS2002, MUST, NRI, and MNA) and the prognostic nutritional index (PNI) were used to assess the nutritional status of patients before surgery, as well as at 1 month, 3 months, and 6 months post-surgery. Finally, we analyzed the factors influencing postoperative recovery outcomes in patients.ResultsCompared to pre-operation, the BMI of patients significantly increased at 1 month, 3 months, and 6 months after the operation, with statistically significant differences (p &lt; 0.001). Multiple nutritional risk assessment tools (NRS2002, MUST, NRI, and MNA), as well as the prognostic nutritional index (NPI), indicated a reduction in nutritional risk and improvement in nutritional status at 1, 3, and 6 months post-surgery, compared to pre-surgery levels (p &lt; 0.001). The levels of albumin, total protein, and hemoglobin in patients at 1, 3, and 6 months after the surgery were significantly higher than those before the surgery (p &lt; 0.001). However, there was no significant change in the number of lymphocytes. Inflammatory markers such as IL-6, IL-8, and CRP exhibited a significant decrease after the surgery, reaching normal levels at 6 months post-surgery (p &lt; 0.001). Low BMI, low PNI, and low cholesterol levels are independent risk factors for patient prognosis (p &lt; 0.05).ConclusionSurgical treatment can enhance the nutritional status of constipation patients with malnutrition, which in turn promotes the restoration of intestinal motility. The patient’s nutritional status will impact the postoperative recovery outcomes.
A bibliometric analysis of the application of physical therapy in knee osteoarthritis from 2013 to 2022
Authors: Huang Chenglan , Hou Yutong , Yang Yunxiao , Liu Jiaqi , Li Ya , Lu Dezhi , Chen Sha , Wang Jinwu 
Published: September 2024

BackgroundKnee osteoarthritis (KOA) is one of the most common chronic joint diseases. Physical therapy, a non-invasive approach, is extensively used in its treatment. Although bibliometrics is a reliable method to evaluate the significance and impact of research fields, systematic bibliometric analyses in this area are lacking. This study aims to perform a bibliometric analysis covering 2013 to 2022, to highlight the current state, key focuses, and trends in physical therapy for KOA.MethodsThis study utilizes the Web of Science Core Collection to gather relevant literature on physical therapy and KOA from 2013 to 2022. CiteSpace and VOSviewer software facilitated the visual analysis of the annual publications, geographic and institutional distributions, journals, authors, references, and keywords in this field.ResultsThe study analyzed 1,357 articles, showing an overall increase in publications over time from 71 countries and 2,302 institutions. The United States and Australia emerged as leaders in this field. The analysis identified 6,046 authors, with Kim L. Bennell as the most prolific and Bellamy N. receiving the most citations. BMC Musculoskeletal Disorders published the most articles, while Osteoarthritis and Cartilage received the most citations. High-impact articles were authored notably by McAlindon TE, Bannuru RR, Fernandes L, and Bennell KL. Keyword analysis highlighted a strong focus on patient self-management, exercise therapy, physical factor therapy, and remote rehabilitation.ConclusionThe bibliometric analysis confirms significant interest and ongoing research in physical therapy for KOA treatment from 2013 to 2022, indicating a growing field. Journals and authors in this area show influential and collaborative dynamics. Future research should focus on enhancing international and institutional collaboration and explore emerging trends like internet-guided treatments.
The role of ALDH2 rs671 polymorphism and C-reactive protein in the phenotypes of male ALS patients
Authors: Huang Lifang , Liu Mao , Tang Jiahui , Gong Zhenxiang , Li Zehui , Yang Yuan , Zhang Min 
Published: September 2024

BackgroundThe aldehyde dehydrogenase 2 (ALDH2) rs671 (A) allele has been implicated in neurodegeneration, potentially through oxidative and inflammatory pathways. The study aims to investigate the effects of the ALDH2 rs671 (A) allele and high sensitivity C-reactive protein (hs-CRP) on the clinical phenotypes of amyotrophic lateral sclerosis (ALS) in male and female patients.MethodsClinical data and ALDH2 rs671 genotype of 143 ALS patients, including 85 males and 58 females, were collected from January 2018 to December 2022. All patients underwent assessment using the Chinese version of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS). Complete blood count and metabolic profiles were measured. Clinical and laboratory parameters were compared between carriers and non-carriers of the rs671 (A) allele in males and females, respectively. The significant parameters and rs671 (A) Allele were included in multivariate linear regression models to identify potential contributors to motor and cognitive impairment. Mediation analysis was employed to evaluate any mediation effects.ResultsMale patients carrying rs671 (A) allele exhibited higher levels of hs-CRP than non-carriers (1.70 mg/L vs. 0.50 mg/L, p = 0.006). The rs671 (A) allele was identified as an independent risk factor for faster disease progression only in male patients (β = 0.274, 95% CI = 0.048−0.499, p = 0.018). The effect of the rs671 (A) allele on the executive function in male patients was fully mediated by hs-CRP (Indirect effect = −1.790, 95% CI = −4.555−−0.225). No effects of the rs671 (A) allele or hs-CRP were observed in female ALS patients. The effects of the ALDH2 rs671 (A) allele and the mediating role of hs-CRP in male patients remained significant in the sensitivity analyses.ConclusionThe ALDH2 rs671 (A) allele contributed to faster disease progression and hs-CRP mediated cognitive impairment in male ALS patients.
Diagnostic accuracy of cytology and urine methylation test in patients with non-muscle invasive bladder cancer: a systematic review and meta-analysis
Authors: Yao Zhuoyue , Wang Tao , Liu Jingpeng , Zhou Zhongbao , Zhang Yong 
Published: September 2024

BackgroundMultiple clinical studies have demonstrated the numerous advantages of urine methylation test over cytology for monitoring patients with non-muscle invasive bladder cancer (NMIBC) following surgery. This research aims to provide a systematic review and meta-analysis to evaluate the efficacy and limits of urine methylation test in the clinical management of NMIBC.MethodsThis research was carried out by conducting a comprehensive search of clinical trials comparing cytology and urine methylation test for NMIBC follow-up using databases such as PubMed, Embase, Web of Science, and the Cochrane Library up until May 2023, including references from relevant articles. The study is registered on PROSPERO with ID CRD42023398969.ResultThis study comprised six studies with a total of 1676 patients. The analysis revealed that the AUC of urine methylation test had a greater AUC than that of the cytology examination (0.89 vs 0.71). In post-operative follow-up of patients with NMIBC, the urine methylation test demonstrated a significant sensitivity (0.69 vs 0.52), but with lower specificity (0.87 vs 0.93) than cytology examination.ConclusionThe urine methylation test and cytology examination have both shown strong diagnostic performance in screening for NMIBC patients. However, urine methylation test outperforms cytology examination in terms of accuracy and sensitivity.Systematic review registrationPROSPERO, identifier CRD42023398969.