bluuebunny/crossref_metadata_2025_split huggingface dataset:
A qualitative, theory-based exploration of facilitators and barriers for implementation of pharmacist prescribing in chronic kidney disease
Authors: Al Raiisi Fatma , Cunningham Scott , Stewart Derek 
Published: September 2024

Abstract
Background
While there is an accumulation of evidence that pharmacist prescribing is safe and effective, there is a lack of research on processes of implementation into practice, particularly for patients with complex clinical conditions such as chronic kidney disease (CKD).

Aim
The aim was to explore the facilitators and barriers to the implementation of pharmacist prescribing for patients with CKD in the United Kingdom (UK).

Method
Semi-structured interviews were conducted with UK Renal Pharmacy Group members who were independent prescribers. The Consolidated Framework for Implementation Research (CFIR) underpinned the interview schedule. Interviews were recorded, transcribed, and independently coded by two researchers. A thematic approach was used for analysis, with data generation continuing until saturation of themes. Ethical approval was granted.

Results
Data saturation was achieved following 14 interviews. Most interviewees were female (n = 11), all had secondary care as their main practice setting, and were highly experienced prescribers with 8 having 11 or more years of prescribing practice. Interviewees were positive regarding the development of their prescribing practice. Facilitators and barriers emerged across all 5 of the CFIR domains. Key facilitators were aspects of inner setting (e.g., organisational support and communication) while key barriers were also related to inner setting, specifically the need for adequate structural and financial resources.

Conclusion
This theory-based study has illuminated the facilitators and barriers for the implementation of pharmacist prescribing in CKD. There is a need to consider the resources required for implementation of prescribing practice at an early stage of planning and development.
Intentional summer flooding of an Avicennia germinans mangrove forest has a more direct effect on ammonia-oxidizing Betaproteobacteria than on Thaumarchaea
Authors: Laanbroek H. J. , Hefting M. M. , Costa O. Y. A. , Kuramae E. E. 
Published: September 2024

Abstract
Aims
Rotational Impoundment Management (RIM) involves summer inundation of impounded mangrove forests for mosquito management. The goal of this study was to investigate the impact of RIM on communities of aerobic ammonia-oxidizing microorganisms in Avicennia germinans dominated mangrove forest soils.

Methods
Soil samples were collected annually in a managed and an adjacent, non-managed impoundment before and after the start of RIM at three elevation levels with their characteristic mangrove habitats, i.e., dwarf (highest elevation), sparse and dense (lowest elevation). The ammonia-oxidizing communities were studied by qPCR and amplicon analyses based on thaumarchaeal and betaproteobacterial amoA genes.

Results
Temporal variations in copy numbers and assemblies of amoA gene amplicons were limited. Thaumarchaeal amoA genes increased in the dwarf and sparse habitat in the non-managed impoundment, and betaproteobacterial amoA genes increased in the dwarf habitat in the RIM impoundment. No copies of the amoA gene of Nitrospirota (comammox bacteria) were detected in either impoundment. Whereas there were no significant effects of RIM on the composition of thaumarchaeal communities, RIM affected the composition of betaproteobacterial amoA assemblies in all habitats in the RIM impoundment.

Conclusions
Direct consequences of RIM were reflected in changes in the composition of assemblies of amplicon sequence variants (ASVs) of ammonia-oxidizing Betaproteobacteria in all mangrove habitats of the RIM impoundment. Significant temporal changes at higher elevations in the non-managed impoundment were likely due to groundwater exchange between the impoundments.
Engaging Refugee Volunteers in Co-creation: The Role of Non-profit Leadership
Authors: Krasniqi Egzon 
Published: September 2024

AbstractEngagement of vulnerable groups in co-creation has attracted growing scholarly and policy interest. Most research, however, focuses on the public sector, and less is known about the factors that support co-creation with these groups in the third sector. This study explores the role of non-profit leadership in engaging refugees in co-creation through volunteering. It draws on evidence from Veiviser—an NGO-initiated project in Bergen (Norway)—where refugees co-create their integration services by volunteering alongside established immigrants and Norwegian-born volunteers. The findings suggest that engaging vulnerable groups in co-creation in the third sector may be easier because of its voluntary nature and the gatekeeping role of non-profit leaders in a selection process that favors people who are more motivated to participate and capable of doing so. The findings also reveal that creating an environment conducive to participation is critical, requiring leadership commitment to building trust, creating a safe space for participation, fostering equality, and empowering refugee participation. Several leadership tactics for achieving these goals are identified, and implications for practice and theory are discussed.
Neural Tube Organoids: A Novel System to Study Developmental Timing
Authors: Rabeling Alexa , van der Hoven Amy , Andersen Nathalie , Goolam Mubeen 
Published: September 2024

AbstractThe neural tube (NT) is a transient structure formed during embryogenesis which develops into the brain and spinal cord. While mouse models have been commonly used in place of human embryos to study NT development, species-specific differences limit their applicability. One major difference is developmental timing, with NT formation from the neural plate in 16 days in humans compared to 4 days in mice, as well as differences in the time taken to form neuronal subtypes and complete neurogenesis. Neural tube organoids (NTOs) represent a new way to study NT development in vitro. While mouse and human NTOs have been shown to recapitulate the major developmental events of NT formation; it is unknown whether species-specific developmental timing, also termed allochrony, is also recapitulated. This review summarises current research using both mouse and human NTOs and compares developmental timing events in order to assess if allochrony is maintained in organoids.
Graphical Abstract
Microscale analysis of the fish Knightia eocaena taphonomy: Implication of a preserved microbial community
Authors: Rogers Garrett A. , Pittinger Dakota R. , Simpson Edward L. , Friehauf Kurt 
Published: September 2024

AbstractMicrobial communities are important components controlling the fidelity of fossil fish preservation. The Eocene Green River Formation lagerstätten, exceptionally preserved fossil deposits, provides an opportunity to examine the role of microbial communities and their metabolic byproducts, such as chemical precipitated in this spectacularly preserved fish deposit, famous throughout the world. Field emission scanning electron microscope (FESEM) and energy dispersive spectroscopy system (EDS) examination of a well-preserved Knightia eocaena from the Eocene Green River Formation documents the presence of bacteriomorphs. Bacteriomorphs in a sample from the Fossil Butte Member of the Green River Formation consists of spherical structures, coccoid-type bacteria, fibres from two-sized populations of filamentous bacteria, probable filamentous cyanobacteria, capsule-shaped, and bacilliform bacteria, all associated with framboidal iron hydroxide.Bacteriomorphs consist of external molds composed of nanometer-scale calcium carbonate spheres. Fe-oxide framboids have an amorphous exterior and a sieve-like internal structure. The sieve-like structure consists of nanometer-scale pores, probable sites of bacterial cells with walls composed of 100-nanometer-scale spheres. Fe-oxides are consistent with bacterially mediated precipitation of pyrite followed by an oxidation event. Preserved bacteriomorphs are consistent with degradation of soft tissue, limiting the preservation of soft tissue and leaving bone and scales with no appreciable soft tissue. The microfossils are restricted to the skeleton and are not found in the surrounding rock matrix, suggesting larger microbial mats may not have been present and possibly did not have a significant impact on the preservation of this specimen.
Comparative study of free amino acids at metabolite and gene expression levels in Triticeae during cold acclimation
Authors: Singh Kalpita , Gulyás Zsolt , Athmer Benedikt , Kovács Bettina , Mednyánszky Zsuzsanna , Galiba Gábor , Stein Nils , Simon-Sarkadi Lívia , Kocsy Gábor 
Published: September 2024

AbstractThis study investigates the freezing tolerance and cold-induced changes in amino acid metabolism in three Triticeae species (rye, wheat, and barley) with varying levels of freezing tolerance. Freezing tests confirmed that rye exhibited the highest tolerance, while barley showed the highest sensitivity. Cold acclimation significantly increased total free amino acid levels, with wheat and barley showing nearly twice the accumulation compared to rye. The glutamate family of amino acids, particularly proline (Pro), γ-aminobutyric acid (GABA), and glutamine (Gln), displayed substantial increase during cold treatment. Pro levels were notably higher in freezing-tolerant wheat and barley genotypes, suggesting its role in osmotic stress mitigation. However, this correlation was absent in rye. Gene expression analysis revealed that cold-induced proline accumulation is likely regulated at the post-transcriptional level, particularly involving the P5CS gene. These findings highlight the species-specific metabolic adjustments and regulatory mechanisms underlying freezing tolerance in Triticeae species, emphasizing the central role of proline and glutamate family amino acids in cold acclimation.
Enhancing trustworthiness in ML-based network intrusion detection with uncertainty quantification
Authors: Talpini Jacopo , Sartori Fabio , Savi Marco 
Published: September 2024

AbstractA crucial role in the security of modern networks is played by Intrusion Detection Systems (IDSs), security devices designed to identify and mitigate attacks to networks structure. Data-driven approaches based on Machine Learning (ML) have gained more and more popularity for executing the classification tasks required by signature-based IDSs. However, typical ML models adopted for this purpose do not properly take into account the uncertainty associated with their prediction. This poses significant challenges, as they tend to produce misleadingly high classification scores for both misclassified inputs and inputs belonging to unknown classes (e.g. novel attacks), limiting the trustworthiness of existing ML-based solutions. In this paper, we argue that ML-based IDSs should always provide accurate uncertainty quantification to avoid overconfident predictions. In fact, an uncertainty-aware classification would be beneficial to enhance closed-set classification performance, would make it possible to carry out Active Learning, and would help recognize inputs of unknown classes as truly unknowns, unlocking open-set classification capabilities and Out-of-Distribution (OoD) detection. To verify it, we compare various ML-based methods for uncertainty quantification and open-set classification, either specifically designed for or tailored to the domain of network intrusion detection. Moreover, we develop a custom model based on Bayesian Neural Networks that stands out for its OoD detection capabilities and robustness, with a lower variance in the results over different scenarios, compared to other baselines, thus showing how proper uncertainty quantification can be exploited to significantly enhance the trustworthiness of ML-based IDSs.
Promoting University Students’ Well-being and Resilience by Means of a Game-Approach Basic Psychological Need Intervention: a Case Study
Authors: Kiltz Lisa , Fokkens-Bruinsma Marjon , Jansen Ellen P. W. A. 
Published: September 2024

AbstractCompromised university students’ well-being remains a pressing issue that may be addressed with interventions. This case study evaluates a positive psychology intervention aimed to raise awareness regarding how students’ basic psychological needs can promote their well-being (a), provide a shared responsibility for students and teachers to co-create their course (b), and satisfy their needs throughout this process (c). We hypothesised that students in an intervention condition would demonstrate greater need satisfaction than a control condition over time and that greater need satisfaction relates to improved well-being and resilience. In addition, we aimed to understand how the participants perceived the intervention. We compared an intervention course (n = 56) with a control course (n = 25). We tested the intervention with a mixed-method pre-post design and used quantitative survey as well as qualitative observational and interview data. We found mixed findings regarding the intervention’s impact on students, with qualitative data providing a more nuanced picture. Although their needs remain unaffected by the intervention, they qualitatively reported that it satisfied their autonomy, competence, and relatedness. Of the three needs, only competence related to students’ well-being and resilience, but qualitatively, they stressed autonomy and relatedness as essential as well. When asked how they experienced the intervention, participants noted issues, such as social hesitance when playing with strangers, though they also reported various benefits regarding the content and social aspects. Therefore, we see potential in such game-based systemic interventions to create a healthy academic learning environment.
Topography of textured surfaces using an abrasive-water jet technology
Authors: Szada-Borzyszkowska Monika , Kacalak Wojciech , Szada-Borzyszkowski Wiesław , Borkowski Przemysław J. , Laskowska Dorota , Szafraniec Filip 
Published: September 2024

AbstractSurface texturing is a technique that allows for the shaping of surface topography to meet various mechanical and tribological requirements. Abrasive-water jet (AWJ) technology is a promising approach to surface texturing, offering minimal heat impact, flexibility, and compatibility with complex surface geometries. High-pressure abrasive-water jet (AWJ) technology, as an innovative and versatile approach, significantly expands the possibilities of surface texturing for materials. Its advantages, such as precision, minimal thermal impact, sustainability, and a wide range of industrial applications, make it an attractive solution across various sectors. With continuous development and integration with modern digital technologies, AWJ is becoming an increasingly practical and cutting-edge tool in surface processing. The abrasive-water jet texturing process also affects surface geometry during the mating of components, which may be significant in reducing wear. The aim of the research was to determine the feasibility of obtaining specific structures on the surface of 304/1.4301 steel using abrasive-water jet technology. Results show that the highest load-bearing ratio of Smrk1 peaks, approximately 25%, was achieved at a texturing speed of 0.803 m/min. Conversely, the lowest load-bearing ratio of Smrk1 peaks, below 10%, was achieved at a texturing speed of 1.948 m/min. Grinding the surface after texturing increases its load-bearing capacity, leading to a twofold increase in the ability to maintain an oil layer. The obtained results may find application in various fields where controlling surface geometry is essential for improving material functionality and efficiency.
Epidemiology of Q Fever in Southeast Europe for a 20-Year Period (2002–2021)
Authors: Pustahija Tatjana , Medić Snežana , Vuković Vladimir , Lozanov-Crvenković Zagorka , Patić Aleksandra , Štrbac Mirjana , Jovanović Verica , Dimitrijević Dragana , Milinković Milunka , Kosanović Mirjana Lana , Maltezou Helena C. , Mellou Kassiani , Musa Sanjin , Bakić Marijan , Medenica Sanja , Sokolovska Nikolina , Rodić Nina Vukmir , Devrnja Milica , Ristić Mioljub , Petrović Vladimir 
Published: September 2024

AbstractThis study aimed to assess epidemiological trends of Q fever in six countries of Southeast Europe by analysing surveillance data for 2002–2021 period. In this descriptive analysis, we collected and analysed data on confirmed human Q fever cases, obtained from the national Public Health Institutes of Bosnia and Herzegovina, Croatia, Greece, Montenegro, North Macedonia and Serbia. Overall, 2714 Q fever cases were registered during the 20-year period. The crude average annual notification rate was 0.82 (± 2.06) (95% CI: 0.47–1.16) per 100,000 inhabitants, ranged from 0.06 (± 0.04) (95% CI: 0.04–0.08) /100,000 in Greece to 2.78 (± 4.80) (95% CI: 0.53–5.02) /100,000 in the Republic of Srpska (entity of Bosnia and Herzegovina). Significant declining trends of Q fever age standardized rates were registered in Croatia, the Federation of Bosnia and Herzegovina, North Macedonia and Serbia, with an average annual change of -30.15%; -17.13%; -28.33% and − 24.77%, respectively. An unequal spatial distribution was observed. The highest average age-specific notification rate was reported in the 20–59 age group (0.84 (± 0.40) (95% CI: 0.65–1.02) /100,000). Most cases (53.69%) were reported during the spring. Q fever remains a significant public health threat in this part of Europe. The findings of this study revealed the endemic maintenance of this disease in the including countries, with large regional and subnational disparities in notification rates. A downward trend was found in Q fever notification rates across the study countries with the average notification rate higher than in the EU/EEA, during the same period.
Cerebral perfusion software: comparative evaluation
Authors: Fagotti Cristina , Colarieti Filippo , Cella Marco , Catalucci Alessia , Anselmi Monica , Arrigoni Francesco , Palumbo Pierpaolo , Bruno Federico , Barile Antonio , Di Cesare Ernesto , Splendiani Alessandra 
Published: September 2024

Abstract
Introduction
Perfusion CT (CTP) is crucial in defining the best treatment strategy for patients with acute ischemic stroke. Several software is available for assessing cerebral perfusion maps, which may show some variability in results. We aim to investigate the agreement between CT perfusion values in acute ischemic stroke of 2 different software (Syngo.via and Icobrain) in estimating ischemic core, ischemic penumbra, and mismatch ratio.

Methods
17 patients (10 women, mean age = 79.5 years) with acute stroke with large vessel occlusion (LVO) were enrolled in our study between August 2022 and March 2023. All patients underwent a CTP scan to determine the best treatment approach: endovascular treatment or systemic fibrinolysis according to DAWN/DEFUSE-3 criteria. All CTP examinations were analyzed using 2 different dedicated software (Syngo.via, Icobrain) and the perfusion values obtained (core, penumbra, mismatch ratio) were compared with each other. A basal CT scan 24 h after treatment was acquired to assess the final infarct volume (FIV) and possible hemorrhagic infarction. Then we compared the true FIV, manually assessed, with the predicted FIV calculated by the two software.

Results
The values obtained showed that the mean core volumes calculated by Syngo.via and Icobrain did not exhibit any statistically significant differences with a p-value of 0.09. There is no statistically significant difference between the mean penumbra volumes calculated by the two software (p-value = 0.29). There is no statistically significant difference between the mean values of core and penumbra calculated by both software. Furthermore, both Icobrain and Syngo.via gave the same therapeutic indication. Correlation analysis indicated a slightly stronger correlation between the core volume calculated by Icobrain and the FIV (r = 0.98 vs r = 0.94). Both correlations were statistically significant (p =  < 0.001).

Conclusion
The evaluation of perfusion indices by automated systems may present a certain degree of variability between different software, although they agree on the final therapeutic stratification.
Exploring Concurrent Approach for Respiratory Epidemiological Surveillance and Symptom Screening (CARES): a new strategy for preventing respiratory infection outbreaks in long-term care facilities
Authors: Takayama Naoki , Sakaki Haruyo , Nishioka Midori , Aminaka Mayumi , Shirai Masahiro , Toyoda Atsushi , Endo Eiko 
Published: September 2024

AbstractObjective:The Concurrent Approach for Respiratory Epidemiological Surveillance and Symptom Screening (CARES) combines symptom screening to prevent external respiratory infections by managing staff and visitor health and surveillance to monitor the infection rates within the facility and take timely decisions on activity programs based on outbreak prevalence. This study examines the efficacy of the CARES strategy in preventing respiratory infection outbreaks in long-term care facilities.Design:Prospective cohort study utilizing historical controls including an intervention and control group.Setting:This study was conducted in two long-term care facility wards (total: 110 beds) in Japan.Patients:We enrolled patients aged 1–72 years from the target ward with severe intellectual and physical disabilities from October 1, 2018, to March 31, 2019, and from October 1, 2017, to March 31, 2018, for the intervention (n = 104) and control (n = 98) groups, respectively. The study included all admitted patients and excluded those hospitalized or discharged during the study period.Intervention:The total number of days that activity programs, new admissions, and visitations were cancelled in the two groups was compared before and after the introduction of CARES.Results:CARES reduced the duration of new admission cancellations and visitation cancellations by 16 and 23 days, respectively (α = 0.1, P value < 0.001). Additionally, the maximum duration of activity program cancellations was reduced by 2 days. Furthermore, five cases of presenteeism were prevented.Conclusions:CARES improves patients’ quality of life by continuation of activity programs, new patient admission, and ongoing visitations.