bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Risk Score for Prediction of Extended-Spectrum β-Lactamase–Producing Enterobacteriaceae in Bloodstream Isolates
Authors: Augustine Matthew R. , Testerman Traci L. , Justo Julie Ann , Bookstaver P. Brandon , Kohn Joseph , Albrecht Helmut , Al-Hasan Majdi N. 
Published: December 2016

OBJECTIVETo develop a risk score to predict probability of bloodstream infections (BSIs) due to extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBLE).DESIGNRetrospective case-control study.SETTINGTwo large community hospitals.PATIENTSHospitalized adults with Enterobacteriaceae BSI between January 1, 2010, and June 30, 2015.METHODSMultivariate logistic regression was used to identify independent risk factors for ESBLE BSI. Point allocation in extended-spectrum β-lactamase prediction score (ESBL-PS) was based on regression coefficients.RESULTSAmong 910 patients with Enterobacteriaceae BSI, 42 (4.6%) had ESBLE bloodstream isolates. Most ESBLE BSIs were community onset (33 of 42; 79%), and 25 (60%) were due to Escherichia coli. Independent risk factors for ESBLE BSI and point allocation in ESBL-PS included outpatient procedures within 1 month (adjusted odds ratio [aOR], 8.7; 95% confidence interval [CI], 3.1–22.9; 1 point), prior infections or colonization with ESBLE within 12 months (aOR, 26.8; 95% CI, 7.0–108.2; 4 points), and number of prior courses of β-lactams and/or fluoroquinolones used within 3 months of BSI: 1 course (aOR, 6.3; 95% CI, 2.7–14.7; 1 point), ≥2 courses (aOR, 22.0; 95% CI, 8.6–57.1; 3 points). The area under the receiver operating characteristic curve for the ESBL-PS model was 0.86. Patients with ESBL-PSs of 0, 1, 3, and 4 had estimated probabilities of ESBLE BSI of 0.7%, 5%, 24%, and 44%, respectively. Using ESBL-PS ≥3 to indicate high risk provided a negative predictive value of 97%.CONCLUSIONSESBL-PS estimated patient-specific risk of ESBLE BSI with high discrimination. Incorporation of ESBL-PS with acute severity of illness may improve adequacy of empirical antimicrobial therapy and reduce carbapenem utilization.Infect Control Hosp Epidemiol 2017;38:266–272
Why the Reformation failed in Ireland
Authors: Jefferies Henry A. 
Published: December 2016

AbstractThe Reformation failed comprehensively and absolutely in Ireland before the end of Elizabeth’s reign: contemporaries estimated the number of Irish Protestants at between forty and 120 individuals. The debate about that failure has been long running, yet inconclusive. After a short historiographical review, this paper considers a range of factors which may have been pertinent in shaping Irish responses to the Reformation policies of Henry VIII and his Protestant children. It shows that Elizabeth’s Reformation in Ireland was stymied by the absence of indigenous support, which meant that religious change was neither propagated by local clergymen nor enforced by the local elites in Irish parishes. It points to the strength and persistence of Catholic resistance to the Reformation in different forms from the very start of Elizabeth’s reign in Ireland, contradicting the unsubstantiated notion that passive ‘church papistry’ was general. Nonetheless, it argues that it was only from the 1580s, when the Catholic church in Ireland was reorganised as a disestablished ‘people’s church’, and infused with the confidence inspired by the Counter-Reformation, can it be stated that the Reformation had failed in Ireland definitively.
Select Document: Lord Carnarvon’s memoirs relating to his lord lieutenancy, c. 29 March to 7 April 1886
Authors: Gordon Peter 
Published: December 2016

AbstractThis article examines the memoirs written by Henry Howard Molyneux Herbert, fourth earl of Carnarvon, concerning his period as lord lieutenant of Ireland between June 1885 and January 1886, in the brief Salisbury administration. Carnarvon inherited many of the problems of his Liberal predecessor, fifth Earl Spencer, telling Salisbury ‘the day of reckoning in this case will come very rapidly if any unwise promises are made or implied’. Nevertheless he was sympathetic to reform in many different fields, notably home rule, land reform, education and religion. A sensitive politician, Carnarvon penned this memorandum shortly after leaving office in an attempt to uphold his reputation. The memorandum gives a number of insights into Carnarvon’s manoeuvrings in cabinet, and demonstrates the workings of high politics in the late-nineteenth century. It was never published.
Chameleons at large: Entrepreneurs, employees and firms – the changing context of employment relationships
Authors: Wynn Michael T 
Published: December 2016

AbstractCurrent labour markets are witnessing a proliferation of hybrid or quasi-employment status whereby company directors and limited liability partners are gaining access to employment rights. At the same time, legislation is creating new forms of employee shareholder status, where employees trade employment rights for shares in the company. New corporate structures are being developed to promote one-man companies, small and medium sized enterprises and hybrid company/partnerships. This paper examines some of these developments in the light of the theory of the firm and the jurisprudence of company and employment law and considers the implications for workers, employers and the self-employed.
Five decades of strong temporal variability in the flow of Brunt Ice Shelf, Antarctica
Authors: GUDMUNDSSON G. HILMAR , DE RYDT JAN , NAGLER THOMAS 
Published: December 2016

ABSTRACTData showing velocity changes on the Brunt Ice Shelf (BIS), Antarctica, over the last 55 years are presented and analysed. During this period no large-scale calving events took place and the ice shelf gradually grew in size. Ice flow velocities, however, fluctuated greatly, increasing twofold between 1970 and 2000, then decreasing again to previous levels by 2012 after which velocities started to increase yet again. In the observational period, velocity changes in the order of 10% a−1 have commonly been observed, and currently velocities are increasing at this rate. By modelling the ice flow numerically, we explore potential causes for the observed changes in velocity. We find that a loss of mechanical contact between the BIS and the McDonald Ice Rumples following a local calving event in 1971 would explain both the increase and the subsequent decrease in ice velocities. Other explanations involving enlargement of observed rift structures are discounted as the effects on ice flow are found to be too small and the spatial pattern of velocity change inconsistent with data. The most recent phase of acceleration remains unexplained but may potentially be related to a recent re-activation of a known rift structure within the BIS.
Determinants of Wineries’ Decisions to Seek VQA Certification in the Canadian Wine Industry
Authors: Ugochukwu Albert I. , Hobbs Jill E. , Bruneau Joel F. 
Published: December 2016

AbstractThe establishment of quality assurance systems is an important development in the wine sector, particularly so for new and emerging wine regions. Focusing on the Canadian wine industry, this article examines the determinants of a winery's decision to adopt Vintners Quality Alliance (VQA) certification for wines. The analysis also examines whether wineries seek VQA certification for higher-priced wines or whether VQA certification leads to higher wine prices. To examine the certification decision, a probit model is applied to a detailed data set of Canadian wines sold in Ontario over the period 2007–2012. Wines from wineries that supply large volumes of wines (more than 1,000 cases) are more likely to have VQA certification, as well as ice wines and wines from specific regions. A Hausman specification test for endogeneity suggests that VQA certification leads to higher wine prices and not the other way around. (JEL Classifications: D22, L15, L66, Q13)
Influences on recovery of seabirds on islands where invasive predators have been eradicated, with a focus on Procellariiformes
Authors: Borrelle Stephanie B. , Boersch-Supan Philipp H. , Gaskin Chris P. , Towns David R. 
Published: December 2016

AbstractProtecting seabirds is a global conservation priority given that 29% of seabird species are threatened with extinction. One of the most acute threats to seabirds is the presence of introduced predators, which depredate seabirds at all life stages, from eggs to adults. Consequently, eradication of invasive predators has been identified as an effective and commonly used approach to seabird conservation. Seabird recovery following the eradication of predators is influenced by complex and interacting environmental and demographic factors, and there are gaps in our understanding of species-specific responses. We reflect on the recovery of seabirds on islands cleared of predators, drawing on the equilibrium theory of island biogeography, and synthesize key influences on recovery reported in the literature. We present a regionally specific case study on the recovery of seabird colonies (n = 98) in the Hauraki Gulf, New Zealand, which is a hotspot of seabird diversity (27 species), with a long history of eradications of invasive predators. We found that on islands cleared of predators seabirds recover over time, and such islands have more diverse seabird assemblages than islands that never had predators. Recovery appears to be influenced by a suite of site- and species-specific factors. Managers may assume that given enough time following eradication of predators, seabirds will recolonize an island. Although time is a factor, proximity to source populations and human activities has a significant effect on recolonization by seabirds, as do demographic traits, colonizing ability and habitat suitability. Therefore, integrating expected site and species-specific recovery responses in the planning of eradications should help guide post-eradication management actions.
THE PRIORITY VIEW
Authors: McCarthy David 
Published: December 2016

Abstract:According to the priority view, or prioritarianism, it matters more to benefit people the worse off they are. But how exactly should the priority view be defined? This article argues for a highly general characterization which essentially involves risk, but makes no use of evaluative measurements or the expected utility axioms. A representation theorem is provided, and when further assumptions are added, common accounts of the priority view are recovered. A defence of the key idea behind the priority view, the priority principle, is provided. But it is argued that the priority view fails on both ethical and conceptual grounds.
Habitat suitability and impacts of climate change on the distribution of wintering population of Asian Houbara BustardChlamydotis macqueeniiin Iran
Authors: YOUSEFI MASOUD , AHMADI MOHSEN , NOURANI ELHAM , REZAEI ALI , KAFASH ANOOSHE , KHANI ALI , SEHHATISABET MOHAMMAD EBRAHIM , ADIBI MOHAMAD ALI , GOUDARZI FAHIMEH , KABOLI MOHAMMAD 
Published: December 2016

SummaryWe developed a habitat suitability model for wintering populations of the Asian Houbara BustardChlamydotis macqueeniiin Iran and determined environmental variables affecting its occurrence. Our results indicate that various patches in central, western and eastern Iran provide the most suitable habitats for the Houbara. Annual precipitation, slope and distance to croplands were the most important variables for predicting Houbara occurrence. We also determined the effects future climate changes on the distribution of the Houbara in Iran. Results showed that suitable habitats for the wintering Houbara will increase in Iran, but will also considerably shift under future climatic conditions. The distribution maps that we present for the present and future climatic conditions can have important implications for the conservation and management of Houbara populations in Iran.
Analyzing lexical emergence in Modern American English online – CORRIGENDUM
Authors: GRIEVE JACK , NINI ANDREA , GUO DIANSHENG 
Published: December 2016

In the above mentioned article by Grieve, Nini & Guo, an error has occurred in the section numbering.Section 4 is missing and has been mistakenly labelled with section 5. All sections and subsections labelled section 5, should be section 4. Which means section 6 should be renamed section 5.
Sun exposure, UV irradiance and serum 25-hydroxycholecalciferol in pregnant women in rural north India
Authors: Sudhanshu Siddhnath , Upadhyay Pramod , Sahu Monashish , Rawat Vinita , Bhatia Vijayalakshmi 
Published: December 2016

AbstractObjectiveTo document the effect of season and environmental pollution on UVB irradiance; and to estimate cutaneous vitamin D synthesis in village women in different seasons.DesignRadiant UVB energy was measured by a spectroradiometer in different seasons and, in April and May, on successive days in open areas at the city outskirts, at a crowded inner-city area and the villages of our participants. Clothing, outdoor activity pattern and serum 25-hydroxycholecalciferol (25(OH)D) levels were documented.SettingRural north India, latitude 26·8°N.SubjectsPregnant women (n 139, aged 20–40 years).ResultsUVB irradiance ranged from 56 µW/cm2 in January to 470 µW/cm2 in June. Proportion of skin exposed was 18·5 % in summer and 9·5 % in winter. Mean (sd) daily duration of sun exposure was 3·2 (0·2) h during winter and 2·1 (0·4) h during summer. Cutaneous vitamin D synthesis was estimated to be 19·25 µg (770 IU) during winter and 37·25 µg (1490 IU) during summer. Mean (sd) serum 25(OH)D was 28 (15) nmol/l during winter (92 % of participants with <50 nmol/l) and reached 56 (20) nmol/l during late summer (60 % with >50 nmol/l). Mean (sd) UVB irradiance at peak summer was significantly higher at the open areas and in the villages than at the inner-city location (340 (45) and 310 (60) v. 250 (50) µW/cm2, P=0·03).ConclusionsIn our population, at latitude 26·8°N, poor skin exposure is a limiting factor in all seasons. During winter, low UVB radiation energy also contributes. Particulate pollution limits UVB irradiance. Vitamin D supplementation during winter may be necessary.
A randomised controlled trial of repeated filmed social contact on reducing mental illness-related stigma in young adults
Authors: Koike S. , Yamaguchi S. , Ojio Y. , Ohta K. , Shimada T. , Watanabe K. , Thornicroft G. , Ando S. 
Published: December 2016

Aims.Public stigma alters attitudes towards people with mental illness, and is a particular concern for young people since most mental health problems occur in adolescence and young adulthood. However, little is known about the long-term effects of repeated filmed social contact (FSC) on reducing mental health-related stigma among young adults in the general population, compared with self-instructional Internet search (INS) and control interventions.Methods.This study is a parallel-group randomised controlled trial over 12 months conducted in Tokyo, Japan. A total of 259 university students (malen= 150, mean age = 20.0 years,s.d.= 1.2) were recruited from 20 colleges and universities between November 2013 and July 2014, without being provided information about the mental health-related survey or trial. Participants were assigned to one of three groups before completion of the baseline survey (FSC/INS/control = 89/83/87). The FSC group received a computer-based 30-min social contact film with general mental health education and five follow-up web-based FSCs at 2-month intervals. The INS group undertook a 30-min search for mental health-related information with five follow-up web-based reminders for self-instructional searches at 2-month intervals. The control group played PC games and had no follow-up intervention. The main outcome measures were the future (intended behaviour) domain of the Reported and Intended Behaviour Scale at 12 months after the intervention. Analysis was conducted in September 2015.Results.At the 12-month follow-up, 218 participants completed the survey (84.1%, 75:70:73). The FSC group showed the greatest change at the 12-month follow-up (FSC: mean change 2.11 [95% CI 1.49, 2.73], INS: 1.04 [0.29, 1.80], control: 0.71 [0.09, 1.33]; FSCv.INSp= 0.037, FSCv.controlsp= 0.004). No adverse events were reported during the follow-up period.Conclusions.FSC was more successful in reducing stigma at 12 months after intervention than INS or control interventions. FSC could be used to reduce stigma in educational lectures and anti-stigma campaigns targeted at young people.Study registration.This study is registered at UMIN-CTR (No. UMIN000012239).
PDMS/MWCNT-based tactile sensor array with coplanar electrodes for crosstalk suppression
Authors: Wang Luxian , Peng Huiling , Wang Xiaolin , Chen Xiang , Yang Chunsheng , Yang Bin , Liu Jingquan 
Published: December 2016

AbstractThe severe crosstalk effect is widely present in tactile sensor arrays with a sandwich structure. Here we present a novel design for a resistive tactile sensor array with a coplanar electrode layer and isolated sensing elements, which were made from polydimethylsiloxane (PDMS) doped with multiwalled carbon nanotubes (MWCNTs) for crosstalk suppression. To optimize its properties, both mechanical and electrical properties of PDMS/MWCNT-sensing materials with different PDMS/MWCNT ratios were investigated. The experimental results demonstrate that a 4 wt% of MWCNTs to PDMS is optimal for the sensing materials. In addition, the pressure-sensitive layer consists of three microstructured layers (two aspectant PDMS/MWCNT-based films and one top PDMS-based film) that are bonded together. Because of this three-layer microstructure design, our proposed tactile sensor array shows sensitivity up to −1.10 kPa−1, a response time of 29 ms and reliability in detecting tiny pressures.
Observation of spontaneous spin-splitting in the band structure of an n-type zinc-blende ferromagnetic semiconductor
Authors: Anh Le Duc , Hai Pham Nam , Tanaka Masaaki 
Published: December 2016

AbstractLarge spin-splitting in the conduction band and valence band of ferromagnetic semiconductors, predicted by the influential mean-field Zener model and assumed in many spintronic device proposals, has never been observed in the mainstream p-type Mn-doped ferromagnetic semiconductors. Here, using tunnelling spectroscopy in Esaki-diode structures, we report the observation of such a large spontaneous spin-splitting energy (31.7–50 meV) in the conduction band bottom of n-type ferromagnetic semiconductor (In,Fe)As, which is surprising considering the very weak s-d exchange interaction reported in several zinc-blende type semiconductors. The mean-field Zener model also fails to explain consistently the ferromagnetism and the spin-splitting energy of (In,Fe)As, because we found that the Curie temperature values calculated using the observed spin-splitting energies are much lower than the experimental ones by a factor of 400. These results urge the need for a more sophisticated theory of ferromagnetic semiconductors.
Brain structural plasticity with spaceflight
Authors: Koppelmans Vincent , Bloomberg Jacob J , Mulavara Ajitkumar P , Seidler Rachael D 
Published: December 2016

AbstractHumans undergo extensive sensorimotor adaptation during spaceflight due to altered vestibular inputs and body unloading. No studies have yet evaluated the effects of spaceflight on human brain structure despite the fact that recently reported optic nerve structural changes are hypothesized to occur due to increased intracranial pressure occurring with microgravity. This is the first report on human brain structural changes with spaceflight. We evaluated retrospective longitudinal T2-weighted MRI scans and balance data from 27 astronauts (thirteen ~2-week shuttle crew members and fourteen ~6-month International Space Station crew members) to determine spaceflight effects on brain structure, and whether any pre to postflight brain changes are associated with balance changes. Data were obtained from the NASA Lifetime Surveillance of Astronaut Health. Brain scans were segmented into gray matter maps and normalized into MNI space using a stepwise approach through subject specific templates. Non-parametric permutation testing was used to analyze pre to postflight volumetric gray matter changes. We found extensive volumetric gray matter decreases, including large areas covering the temporal and frontal poles and around the orbits. This effect was larger in International Space Station versus shuttle crew members in some regions. There were bilateral focal gray matter increases within the medial primary somatosensory and motor cortex; i.e., the cerebral areas where the lower limbs are represented. These intriguing findings are observed in a retrospective data set; future prospective studies should probe the underlying mechanisms and behavioral consequences.
An atlas of transcriptional, chromatin accessibility, and surface marker changes in human mesoderm development
Authors: Koh Pang Wei , Sinha Rahul , Barkal Amira A. , Morganti Rachel M. , Chen Angela , Weissman Irving L. , Ang Lay Teng , Kundaje Anshul , Loh Kyle M. 
Published: December 2016

AbstractMesoderm is the developmental precursor to myriad human tissues including bone, heart, and skeletal muscle. Unravelling the molecular events through which these lineages become diversified from one another is integral to developmental biology and understanding changes in cellular fate. To this end, we developed an in vitro system to differentiate human pluripotent stem cells through primitive streak intermediates into paraxial mesoderm and its derivatives (somites, sclerotome, dermomyotome) and separately, into lateral mesoderm and its derivatives (cardiac mesoderm). Whole-population and single-cell analyses of these purified populations of human mesoderm lineages through RNA-seq, ATAC-seq, and high-throughput surface marker screens illustrated how transcriptional changes co-occur with changes in open chromatin and surface marker landscapes throughout human mesoderm development. This molecular atlas will facilitate study of human mesoderm development (which cannot be interrogated in vivo due to restrictions on human embryo studies) and provides a broad resource for the study of gene regulation in development at the single-cell level, knowledge that might one day be exploited for regenerative medicine.
Transcriptome characterisation and simple sequence repeat marker discovery in the seagrass Posidonia oceanica
Authors: D’Esposito D. , Orrù L. , Dattolo E. , Bernardo L. , Lamontanara A. , Orsini L. , Serra I.A , Mazzuca S. , Procaccini G. 
Published: December 2016

AbstractPosidonia oceanica is an endemic seagrass in the Mediterranean Sea, where it provides important ecosystem services and sustains a rich and diverse ecosystem. P. oceanica meadows extend from the surface to 40 meters depth. With the aim of boosting research in this iconic species, we generated a comprehensive RNA-Seq data set for P. oceanica by sequencing specimens collected at two depths and two times during the day. With this approach we attempted to capture the transcriptional diversity associated with change in light and other depth-related environmental factors. Using this extensive data set we generated gene predictions and identified an extensive catalogue of potential Simple Sequence Repeats (SSR) markers. The data generated here will open new avenues for the analysis of population genetic features and functional variation in P. oceanica. In total, 79,235 contigs were obtained by the assembly of 70,453,120 paired end reads. 43,711 contigs were successfully annotated. A total of 17,436 SSR were identified within 13,912 contigs.