bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proteomic Profiling of Serial Prediagnostic Serum Samples for Early Detection of Colon Cancer in the U.S. Military
Authors: Shao Stephanie , Neely Benjamin A. , Kao Tzu-Cheg , Eckhaus Janet , Bourgeois Jolie , Brooks Jasmin , Jones Elizabeth E. , Drake Richard R. , Zhu Kangmin 
Published: December 2016

Abstract
Background: Serum proteomic biomarkers offer a promising approach for early detection of cancer. In this study, we aimed to identify proteomic profiles that could distinguish colon cancer cases from controls using serial prediagnostic serum samples.
Methods: This was a nested case–control study of active duty military members. Cases consisted of 264 patients diagnosed with colon cancer between 2001 and 2009. Controls were matched to cases on age, gender, race, serum sample count, and collection date. We identified peaks that discriminated cases from controls using random forest data analysis with a 2/3 training and 1/3 validation dataset. We then included epidemiologic data to see whether further improvement of model performance was obtainable. Proteins that corresponded to discriminatory peaks were identified.
Results: Peaks with m/z values of 3,119.32, 2,886.67, 2,939.23, and 5,078.81 were found to discriminate cases from controls with a sensitivity of 69% and a specificity of 67% in the year before diagnosis. When smoking status was included, sensitivity increased to 76% while histories of other cancer and tonsillectomy raised specificity to 76%. Peaks at 2,886.67 and 3,119.32 m/z were identified as histone acetyltransferases while 2,939.24 m/z was a transporting ATPase subunit.
Conclusions: Proteomic profiles in the year before cancer diagnosis have the potential to discriminate colon cancer patients from controls, and the addition of epidemiologic information may increase the sensitivity and specificity of discrimination.
Impact: Our findings indicate the potential value of using serum prediagnostic proteomic biomarkers in combination with epidemiologic data for early detection of colon cancer. Cancer Epidemiol Biomarkers Prev; 26(5); 711–8. ©2016 AACR.
PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses
Authors: Sai Jiqing , Owens Philip , Novitskiy Sergey V. , Hawkins Oriana E. , Vilgelm Anna E. , Yang Jinming , Sobolik Tammy , Lavender Nicole , Johnson Andrew C. , McClain Colt , Ayers Gregory D. , Kelley Mark C. , Sanders Melinda , Mayer Ingrid A. , Moses Harold L. , Boothby Mark , Richmond Ann 
Published: December 2016

AbstractPurpose: Metastatic breast cancers continue to elude current therapeutic strategies, including those utilizing PI3K inhibitors. Given the prominent role of PI3Kα,β in tumor growth and PI3Kγ,δ in immune cell function, we sought to determine whether PI3K inhibition altered antitumor immunity.Experimental Design: The effect of PI3K inhibition on tumor growth, metastasis, and antitumor immune response was characterized in mouse models utilizing orthotopic implants of 4T1 or PyMT mammary tumors into syngeneic or PI3Kγ-null mice, and patient-derived breast cancer xenografts in humanized mice. Tumor-infiltrating leukocytes were characterized by IHC and FACS analysis in BKM120 (30 mg/kg, every day) or vehicle-treated mice and PI3Kγnull versus PI3KγWT mice. On the basis of the finding that PI3K inhibition resulted in a more inflammatory tumor leukocyte infiltrate, the therapeutic efficacy of BKM120 (30 mg/kg, every day) and anti-PD1 (100 μg, twice weekly) was evaluated in PyMT tumor–bearing mice.Results: Our findings show that PI3K activity facilitates tumor growth and surprisingly restrains tumor immune surveillance. These activities could be partially suppressed by BKM120 or by genetic deletion of PI3Kγ in the host. The antitumor effect of PI3Kγ loss in host, but not tumor, was partially reversed by CD8+ T-cell depletion. Treatment with therapeutic doses of both BKM120 and antibody to PD-1 resulted in consistent inhibition of tumor growth compared with either agent alone.Conclusions: PI3K inhibition slows tumor growth, enhances antitumor immunity, and heightens susceptibility to immune checkpoint inhibitors. We propose that combining PI3K inhibition with anti-PD1 may be a viable therapeutic approach for triple-negative breast cancer. Clin Cancer Res; 23(13); 3371–84. ©2016 AACR.
Targeting DNA Repair in Cancer: Beyond PARP Inhibitors
Authors: Brown Jessica S. , O'Carrigan Brent , Jackson Stephen P. , Yap Timothy A. 
Published: December 2016

AbstractGermline aberrations in critical DNA-repair and DNA damage–response (DDR) genes cause cancer predisposition, whereas various tumors harbor somatic mutations causing defective DDR/DNA repair. The concept of synthetic lethality can be exploited in such malignancies, as exemplified by approval of poly(ADP-ribose) polymerase inhibitors for treating BRCA1/2-mutated ovarian cancers. Herein, we detail how cellular DDR processes engage various proteins that sense DNA damage, initiate signaling pathways to promote cell-cycle checkpoint activation, trigger apoptosis, and coordinate DNA repair. We focus on novel therapeutic strategies targeting promising DDR targets and discuss challenges of patient selection and the development of rational drug combinations.Significance: Various inhibitors of DDR components are in preclinical and clinical development. A thorough understanding of DDR pathway complexities must now be combined with strategies and lessons learned from the successful registration of PARP inhibitors in order to fully exploit the potential of DDR inhibitors and to ensure their long-term clinical success. Cancer Discov; 7(1); 20–37. ©2016 AACR.
Impaired thrombolytic status predicts adverse cardiac events in patients undergoing primary percutaneous coronary intervention
Authors: Sullivan Keith , Wellsted David , Christopoulos Christos , Farag Mohamed , Gorog Diana A. 
Published: December 2016

SummaryAntithrombotic medications reduce thrombosis but increase bleeding. Identification of ST-elevation myocardial infarction (STEMI) patients at risk of recurrent thrombosis could allow targeted treatment with potent antithrombotic medications, with less potent agents in others, to reduce bleeding. Conventional platelet function tests assess platelet reactivity only, yet there is increasing evidence that endogenous thrombolytic potential determines outcome following thrombus initiation. We investigated whether assessing both platelet reactivity and endogenous thrombolysis, could identify STEMI patients at high-risk of recurrent thrombotic events. Thrombotic status was assessed in STEMI patients, before and after primary percutaneous coronary intervention (PPCI), at discharge and at 30 days; with 12 months’ followup. The time to form an occlusive thrombus under high shear (occlusion time, OT), and time to restore flow by endogenous thrombolysis (lysis time, LT) was measured using the point-of-care Global Thrombosis Test (GTT) in the cardiac catheterisation laboratory. Impaired endogenous thrombolysis (prolonged LT ≥ 3000 s), seen in 13 % patients pre-PPCI, was related to major adverse cardiac events, MACE (HR: 3.31, 95 %CI: 1.02–10.78, p = 0.045), driven by cardiovascular death (HR: 4.17, 95 %CI: 0.99–17.51, p = 0.05). Enhanced (rapid) endogenous thrombolysis (LT < 1000 s) was associated with spontaneous reperfusion, ST-segment resolution and Thrombolysis In Myocardial Infarction 3 flow pre-PPCI. Baseline OT was shorter in those with MACE (especially recurrent myocardial infarction and stroke) than those without (253 ± 150 s vs 354 ± 134 s, p=0.017). Endogenous thrombolysis, when impaired, is associated with increased cardiovascular risk, and when enhanced, with spontaneous reperfusion. Endogenous thrombolysis may be a novel target for pharmacological intervention, and allow targeting of potent antithrombotic medications to high-risk patients.
Comparison of the biocompatibility of grey mineral trioxide aggregate and sealapex plus zinc oxide in rat subcutaneous tissue
Authors: Vita Waldécio , Reis Mitermayer Galvão , Santos Theo Araujo , Carvalho Ana Maria , Mota Cristina , Ramos Eduardo Antonio Gonçalves 
Published: December 2016

ABSTRACT Objectives:The aim of this study was to compare the subcutaneous tissue response to grey mineral trioxide aggregate white Sealapex plus zinc oxide. Methods: Polyethylene tubes filled with tested material were implanted in the connective tissue of rats. Control animals received empty tubes. Tissue samples were collected after 7, 60, and 90 days and stained with hematoxylin-eosin, picrosirius-fast green, and von Kossa stain for morphological analysis. The connective tissue response to the implanted materials was evaluated descriptively and semi-quantitatively by scoring the degree of inflammation, granulation tissue formation, fibrosis, and calcification. Results: Examinations of the grey mineral trioxide aggregate group over time revealed more intense inflammation at 7 days than at 60 days (p <0.05). In the Sealapex plus zinc oxide group, granulation tissue was more abundant at 7 days than at 60 days (p <0.05). Regarding calcification, von Kossa-positive granules were observed in the grey mineral trioxide aggregate and Sealapex plus zinc oxide groups at all time points studied. In the Sealapex/ZnO group, calcification was more apparent at 60 days than at 7 days (p <0.05). Relevance: This study demonstrates that all tested materials promote similar tissue reactions. Descriptors: Biocompatibility Testing, Endodontics, Dental Materials, Retrograde Obturation.
Regional Longitudinal Deformation Improves Prediction of Ventricular Tachyarrhythmias in Patients With Heart Failure With Reduced Ejection Fraction
Authors: Biering-Sørensen Tor , Knappe Dorit , Pouleur Anne-Catherine , Claggett Brian , Wang Paul J. , Moss Arthur J. , Solomon Scott D. , Kutyifa Valentina 
Published: December 2016

Background—
Left ventricular dysfunction is a known predictor of ventricular arrhythmias. We hypothesized that measures of regional longitudinal deformation by speckle-tracking echocardiography predict ventricular tachyarrhythmias and provide incremental prognostic information over clinical and conventional echocardiographic characteristics.

Methods and Results—

We studied 1064 patients enrolled in the MADIT-CRT trial (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy) with speckle-tracking data available. Peak longitudinal strain was obtained for the septal, lateral, anterior, and inferior myocardial walls at baseline. The end point was the first event of ventricular tachycardia (VT) or fibrillation (VF). During the median follow-up of 2.9 years, 254 (24%) patients developed VT/VF. Patients with VT/VF had significantly lower left ventricular ejection fraction (28.3% versus 29.5%;
P
<0.001) and longitudinal strain in all myocardial walls compared with patients without VT/VF (anterior-strain, −7.7% versus −8.8%;
P
<0.001; lateral-strain, −7.3% versus −7.9%;
P
=0.022; inferior-strain, −8.3% versus −9.9%;
P
<0.001; septal-strain, −9.1% versus −10.0%;
P
<0.001). After multivariate adjustment, only anterior and inferior longitudinal strain remained independent predictors of VT/VF (anterior: hazard ratio, 1.08 [1.03–1.13];
P
=0.001; inferior: hazard ratio, 1.08 [1.04–1.12];
P
<0.001; per 1% absolute decrease for both). When including B-type natriuretic peptide in the model, only a decreasing myocardial function in the inferior myocardial wall predicted VT/VF (hazard ratio, 1.05 [1.00–1.11];
P
=0.039). Only strain obtained from the inferior myocardial wall provided incremental prognostic information for VT/VF over clinical and echocardiographic parameters (C statistic 0.71 versus 0.69;
P
=0.005).

Conclusions—
Assessment of regional longitudinal myocardial deformation in the inferior region provided incremental prognostic information over clinical and echocardiographic risk factors in predicting ventricular tachyarrhythmias.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00180271.
A revision of the Neogene Conidae and Conorbidae (Gastropoda) of the Paratethys Sea
Authors: HARZHAUSER MATHIAS , LANDAU BERNARD 
Published: December 2016

The Miocene Conidae and Conorbidae of the central- and south-eastern European Paratethys Sea are revised. In total, 74 species are described of which 10 are new species and 5 are documented for the first time from Paratethyan localities. Species descriptions and delimitations are partly based on morphometric data. In addition, colour patterns are described for the first time for the majority of species. In respect to the ongoing discussion on the supraspecific treatment of extant Conidae, we strongly focus on generic allocations and provide a key for the genera as understood herein. Biogeographically, the larger part of the assemblage indicates affiliation with modern western African faunas as indicated by the occurrence of genera such as Lautoconus, Kalloconus, Monteiroconus and Pseudonoduloconus. The relationship with Indo-West Pacific faunas is comparatively low. The high alpha-diversities observed for localities in the Pannonian, Transylvanian and Vienna basins, with up to 44 species, is a marker of tropical conditions in the Paratethys Sea during middle Miocene times. Conasprella minutissima nov. sp., Kalloconus hendricksi nov. sp., Kalloconus letkesensis nov. sp., Kalloconus pseudohungaricus nov. sp., Lautoconus kovacsi nov. sp., Lautoconus pestensis nov. sp., Lautoconus quaggaoides nov. sp., Leporiconus paratethyianus nov. sp., Plagioconus breitenbergeri nov. sp. and Plagioconus bellissimus nov. sp. are described as new species; Conilithes eichwaldi nov. nom. is proposed as new name for Conus exiguus Eichwald, 1830 [non Lamarck, 1810].
A Comparison of Methods Used to Populate Neighborhood-Based Contingency Tables for High-Resolution Forecast Verification
Authors: Schwartz Craig S. 
Published: December 2016

Abstract
As high-resolution numerical weather prediction models are now commonplace, “neighborhood” verification metrics are regularly employed to evaluate forecast quality. These neighborhood approaches relax the requirement that perfect forecasts must match observations at the grid scale, contrasting traditional point-by-point verification methods. One recently proposed metric, the neighborhood equitable threat score, is calculated from 2 × 2 contingency tables that are populated within a neighborhood framework. However, the literature suggests three subtly different methods of populating neighborhood-based contingency tables. Thus, this work compares and contrasts these three variants and shows they yield statistically significantly different conclusions regarding forecast performance, illustrating that neighborhood-based contingency tables should be constructed carefully and transparently. Furthermore, this paper shows how two of the methods use inconsistent event definitions and suggests a “neighborhood maximum” approach be used to fill neighborhood-based contingency tables.
Plans and Prospects for Coastal Flooding in Four Communities Affected by Sandy
Authors: Wong-Parodi Gabrielle , Fischhoff Baruch , Strauss Ben 
Published: December 2016

Abstract
The risk of coastal flooding is increasing due to more frequent intense storm events, rising sea levels, and more people living in flood-prone areas. Although private adaptation measures can reduce damage and risk, most people living in risk-prone areas take only a fraction of those measures voluntarily. The present study examines relationships among individuals’ beliefs and actions regarding flood-related risks based on in-depth interviews and structured surveys in communities deeply affected by Superstorm Sandy. The authors find that residents recognize the risk of coastal flooding and expect it to increase, although they appear to underestimate by how much. Although interview participants typically cited climate change as affecting the risks that they face, survey respondents’ acceptance of climate change was unrelated to their willingness to tolerate coastal flooding risks, their beliefs about the effectiveness of community-level mitigation measures, or their willingness to take individual actions. Respondents who reported greater social support also reported both greater tolerance for flood risks and greater confidence in community adaptation measures, suggesting an important, but complex role of personal connections in collective resilience—both keeping people in place and helping them to survive there. Thus, residents were aware of the risks and willing to undertake both personal and community actions, if convinced of their effectiveness, regardless of their acceptance of climate change.
Impacts of Typhoons on Local Labor Markets based on GMM: An Empirical Study of Guangdong Province, China
Authors: Wu Xianhua , Zhou Lei , Guo Ji , Liu Hui 
Published: December 2016

Abstract
What impacts do typhoons have on local labor markets? Few empirical researches have been conducted in China. By collecting the data of 23 quarters (3-month intervals) of Guangdong province from 2009 to 2014 and using the generalized method of moments (GMM), this paper analyzes the impacts of typhoons on labor markets from the perspectives of general effect, regional effect, intensity effect, and time effect. In addition, a comparative analysis is carried out between this study and similar studies of developed countries. The results show that 1) massive typhoons resulted in a 12.5% increase in employment but did not have a significant impact on Guangdong’s per capita employee remuneration, and 2) there are periodic features to typhoons’ impacts on employment. Typhoons influence employment in a four-quarter cycle. In the quarter affected by a typhoon, the first quarter, the number of employees increased by 17.4%. The quantity of labor employed in the subsequent two quarters shows no significant change. In the last quarter, the number of employed people decreases by 17.0%, which returns to predisaster levels. Additionally, 3) the results of this study are different from those of studies involving developed countries, which may be caused by the distinctiveness of China’s labor market. Finally, conclusions and corresponding suggestions are presented.
Impact of obesity and epicardial fat on early left atrial dysfunction assessed by cardiac MRI strain analysis
Authors: Evin Morgane , Broadhouse Kathryn M. , Callaghan Fraser M. , McGrath Rachel T. , Glastras Sarah , Kozor Rebecca , Hocking Samantha L. , Lamy Jérôme , Redheuil Alban , Kachenoura Nadjia , Fulcher Greg R. , Figtree Gemma A. , Grieve Stuart M. 
Published: December 2016

Abstract
Background
Diastolic dysfunction is a major cause of morbidity in obese individuals. We aimed to assess the ability of magnetic resonance imaging (MRI) derived left atrial (LA) strain to detect early diastolic dysfunction in individuals with obesity and type 2 diabetes, and to explore the association between cardiac adipose tissue and LA function.

Methods
Twenty patients with obesity and T2D (55 ± 8 years) and nineteen healthy controls (48 ± 13 years) were imaged using cine steady state free precession and 2-point Dixon cardiovascular magnetic resonance. LA function was quantified using a feature tracking technique with definition of phasic longitudinal strain and strain rates, as well as radial motion fraction and radial velocities.

Results
Systolic left ventricular size and function were similar between the obesity and type 2 diabetes and control groups by MRI. All patients except four had normal diastolic assessment by echocardiography. In contrast, measures of LA function using magnetic resonance feature tracking were uniformly altered in the obesity and type 2 diabetes group only. Although there was no significant difference in intra-myocardial fat fraction, Dixon 3D epicardial fat volume(EFV) was significantly elevated in the obesity and type 2 diabetes versus control group (135 ± 31 vs. 90 ± 30 mL/m2, p < 0.001). There were significant correlations between LA functional indices and both BMI and EFV (p ≤ 0.007).

Conclusions
LA MRI-strain may be a sensitive tool for the detection of early diastolic dysfunction in individuals with obesity and type 2 diabetes and correlated with BMI and epicardial fat supporting a possible association between adiposity and LA strain.
Trials Registration Australian New Zealand Clinical Trials Registry No. ACTRN12613001069741
Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice
Authors: Liu Chao , Song Zhenhua , Wang Lina , Yu Haiyan , Liu Weixiao , Shang Yongliang , Xu Zhiliang , Zhao Haichao , Gao Fengyi , Wen Jiamin , Zhao Linan , Gui Yaoting , Jiao Jianwei , Gao Fei , Li Wei 
Published: December 2016

ABSTRACT
Sirt1 is a member of the sirtuin family of proteins and has important roles in numerous biological processes. Sirt1−/− mice display an increased frequency of abnormal spermatozoa, but the mechanism of Sirt1 in spermiogenesis remains largely unknown. Here, we report that Sirt1 might be directly involved in spermiogenesis in germ cells but not in steroidogenic cells. Germ cell-specific Sirt1 knockout mice were almost completely infertile; the early mitotic and meiotic progression of germ cells in spermatogenesis were not obviously affected after Sirt1 depletion, but subsequent spermiogenesis was disrupted by a defect in acrosome biogenesis, which resulted in a phenotype similar to that observed in human globozoospermia. In addition, LC3 and Atg7 deacetylation was disrupted in spermatids after knocking out Sirt1, which affected the redistribution of LC3 from the nucleus to the cytoplasm and the activation of autophagy. Furthermore, Sirt1 depletion resulted in the failure of LC3 to be recruited to Golgi apparatus-derived vesicles and in the failure of GOPC and PICK1 to be recruited to nucleus-associated acrosomal vesicles. Taken together, these findings reveal that Sirt1 has a novel physiological function in acrosome biogenesis.
Case Report: A giant myopericytoma involving the occipital region of the scalp - a rare entity
Authors: Munakomi Sunil , Chaudhary Pramod 
Published: December 2016

Herein we report a rare case of a giant myopericytoma presenting in a 16-year-old girl as a slowly progressive swelling involving the scalp in the occipital region. It was managed by complete excision. Histological examination of the lesion revealed spindle-shaped cells forming characteristic rosettes around the blood vessels, and positive staining with smooth muscle actin.
UNA VISIÓN LATINOAMERICANA DE LA ETNOMATEMÁTICA: TENSIONES Y DESAFÍOS
Authors: Peña-Rincón Pilar , Tamayo Osorio Carolina , Parra Aldo 
Published: December 2016

Esta editorial presenta una visión latinoamericana de la Etnomatemática desde la experiencia de tres investigadoresque for ma mos parte de la Red Latinoamericana de la Etnomatemática, RELAET. El planteamiento central es que la Etnomatemática permite comprender otras formas de ser, conocer y relacionarse con el mundo desde una perspectiva descolonizadora, y desde allí es posible problematizar lo que entendemos por conocimiento matemático. Posteriormente planteamos algunas concepciones, tensiones y desafíos que hacen parte de este campo de investigación.
Chronic Type A Aortic Dissection and Giant Aortic Root Aneurysm After Aortic Valve Replacement
Authors: Puga Andrés Enríquez , Rodríguez Sara Castaño , Pañero Blanca Mateos , Moreira Beatriz Castaño , López Almodóvar Luis Fernando 
Published: December 2016

AbstractWe describe the case of a 61-year-old male with a giant aortic root aneurysm associated with chronic aortic Type A dissection. The patient had been operated on 16 years before due to aortic annuloectasia with mechanical valve replacement. The patient underwent revision aortic surgery with a Bentall-De Bono operation with Svensson modification, using a #21 On-X Valsalva mechanical valve conduit. The postoperative course was uneventful.