bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self-reported Preparedness to Respond to Mass Fatality Incidents in 38 State Health Departments
Authors: Merrill Jacqueline , Zhi Qi , Gershon Robyn R. 
Published: November 2016

Context:
Public health departments play an important role in the preparation and response to mass fatality incidents (MFIs).

Objective:
To describe MFI response capabilities of US state health departments.

Design:
The data are part of a multisector cross-sectional study aimed at 5 sectors that comprise the US mass fatality infrastructure. Data were collected over a 6-week period via a self-administered, anonymous Web-based survey.

Setting:
In 2014, a link to the survey was distributed via e-mail to health departments in 50 states and the District of Columbia.

Participants:
State health department representatives responsible for their state's MFI plans.

Measures:
Preparedness was assessed using 3 newly developed metrics: organizational capabilities (n = 19 items); operational capabilities (n = 19 items); and resource-sharing capabilities (n = 13 items).

Results:
Response rate was 75% (n = 38). Among 38 responses, 37 rated their workplace moderately or well prepared; 45% reported MFI training, but only 30% reported training on MFI with hazardous contaminants; 58% estimated high levels of staff willingness to respond, but that dropped to 40% if MFIs involved hazardous contaminants; and 84% reported a need for more training. On average, 76% of operational capabilities were present. Resource sharing was most prevalent with state Office of Emergency Management but less evident with faith-based organizations and agencies within the medical examiner sector.

Conclusion:
Overall response capability was adequate, with gaps found in capabilities where public health shares responsibility with other sectors. Collaborative training with other sectors is critical to ensure optimal response to future MFIs, but recent funding cuts in public health preparedness may adversely impact this critical preparedness element. In order for the sector to effectively meet its public health MFI responsibilities as delineated in the National Response Framework, resources to support training and other elements of preparedness must be maintained.
Fat Suppressed Contrast-Enhanced T1-Weighted Dynamic Magnetic Resonance Imaging at 3T: Comparison of Image Quality Between Spectrally Adiabatic Iversion Recovery and the Multiecho Dixon Technique in Imaging of the Prostate
Authors: Iyama Yuji , Nakaura Takeshi , Kidoh Masafumi , Katahira Kazuhiro , Namimoto Tomohiro , Morishita Shoji , Yamashita Yasuyuki 
Published: November 2016

Objective
To compare the quality of fat suppression and image quality between multiecho Dixon technique (mDixon) and spectrally adiabatic iversion recovery (SPAIR) in dynamic contrast-enhanced magnetic resonance imaging of the prostate.

Methods
This prospective study assigned thirty consecutive patients to scanning with SPAIR technique (SPAIR protocol) and another consecutive 30 patients to scanning with mDixon technique (mDixon protocol). We calculated the contrast, signal to noise ratio (SNR), contrast to noise ratio (CNR) and the coefficient of variation between the 2 protocols. Two readers compared homogeneity of fat suppression, image noise, image contrast, and image sharpness between the two protocols.

Results
The SNR, CNR, and contrast of mDixon protocol were significantly higher than those of the SPAIR protocol (SNR: 14.7 ± 4.1 vs 11.0 ± 2.6; P < 0.05; CNR: 6.3 ± 1.6 vs 0.5 ± 1.5; P < 0.01; contrast: 4.4 ± 1.4 vs 1.3 ± 0.5; P < 0.01), whereas the coefficient of variation of mDixon protocol was significantly lower than that of SPAIR protocol (34.7 ± 15.5 vs 43.7 ± 23.1, P < 0.01). In qualitative image analysis, the image scores for the homogeneity of fat suppression, image noise, and image sharpness were significantly higher with mDixon protocol than those with SPAIR protocol (P < 0.01). There was no significant difference in image contrast between 2 fat suppression protocols (P > 0.05).

Conclusions
In dynamic contrast-enhanced magnetic resonance imaging of the prostate, mDixon technique improved the homogeneity of fat suppression without degrade of image quality compared with SPAIR technique.
Susceptibility Weighted With Quantitative Phase Magnetic Resonance Imaging in Differentiation of Various Stages of Hemorrhage and Calcification in Female Pelvic Pathologies: A Preliminary Study
Authors: Khurana Sakshi , Sahoo Prativa , Kapila Mukta , Mittal Swati , Mahajan Manavita , Saha Indrajit , Gupta Rakesh Kumar 
Published: November 2016

Background
The purposes of this study were to assess the value of phase for characterization of female pelvic lesions with hemorrhage in various stages and to differentiate them from calcified lesions at 3.0-T magnetic resonance imaging (MRI).

Methods
Forty-four female patients with hemorrhagic (n = 37) or calcified (n = 7) pelvic pathology underwent conventional MRI including susceptibility-weighted imaging with phase information. Hemorrhagic lesions were grouped into acute, subacute, and chronic, and calcified lesions were detected on the basis of conventional imaging findings. Phase quantification of these hemorrhagic and calcified lesions was performed.

Results
The phase values significantly differed (P < 0.001) among various stages of hemorrhage, as well as calcification (chronic hemorrhage, −65.09 ± 9.09 degrees; subacute hemorrhage, −11.41 ± 4.4 degrees; acute hemorrhage, −42.30 ± 5.20 degrees; and calcified lesions, 117.55 ± 12.93 degrees).

Conclusions
Quantitative phase imaging has the potential to differentiate various stages of hemorrhagic and calcified pathologies. This may add value to the conventional MRI in improved characterization of these entities in female pelvic pathologies.
Bifid Mandibular Canals Incidence and Anatomical Variations in the Population of Shanghai Area by Cone Beam Computed Tomography
Authors: Yang Xiaoli , Lyu Chengqi , Zou Derong 
Published: November 2016

Objective
The aim of this study was to analyze the rate, location, and characteristics of bifid mandibular canals (BMCs) in the population of the Shanghai area using cone beam computed tomography to avoid complications during surgical procedures.

Methods
Two hundred eighty patients were recruited for this study, and the presence and morphology of BMCs were evaluated.

Results
The occurrence rate of BMCs in the Shanghai area was relatively high compared with that in other populations, reaching 31.1%. In addition, the study also found some far less-common trifid mandibular canals, as well as a peculiarly shaped special type, which we called v-type canal that has yet to be described.

Conclusions
Our study underlined the different characteristics and occurrence rates of BMCs in the population of the Shanghai area and the importance of using cone beam computed tomography for a reliable detection, providing useful information to help prevent presurgery and postsurgery complications.
Disease Activity Score on 28 Joints and Polypharmacy Are Independent Predictors for Health-Related Quality of Life Evaluated by INCAVISA in Patients With Rheumatoid Arthritis
Authors: González-Gamboa Linda Mariana , Barocio-Ramírez Ana Karen , Rocha-Muñoz Alberto Daniel , de Santos-Ávila Fabiola , Meda-Lara Rosa M. , González-López Laura , Gámez-Nava Jorge Iván , Gómez-Bañuelos Eduardo , Chavarria-Avila Efrain , Durán-Barragán Sergio , Navarro-Hernández Rosa Elena , Pizano-Martínez Oscar Enrique , Nuñez-Atahualpa Lourdes , Vázquez-del Mercado Mónica 
Published: November 2016

Objective
The aim of this study was to investigate the main factors associated to a diminished health-related quality of life (HRQoL) evaluated by INCAVISA (Health-Related Quality of Life Inventory for Latin American Patients) in patients with rheumatoid arthritis (RA).

Methods
Female, 18 years or older, RA (American College of Rheumatology 1987 criteria and American College of Rheumatology/European League against Rheumatism 2010 criteria) patients who attended the outpatient rheumatology department of the Hospital Civil “Dr. Juan I. Menchaca,” Guadalajara, Mexico, matched with healthy controls were included. Patients with any known comorbidities or treatment with antidepressive drugs were excluded. Trained physicians performed the RA clinical evaluation and INCAVISA. All data were analyzed using SPSS 21.0 software (SPSS Inc, Chicago, IL); P < 0.05 was considered statistically significant.

Results
Patients with polypharmacy (≥3 drugs) had a lower HRQoL by INCAVISA. The number of drugs, total comorbidities, and DAS-28 (Disease Activity Score on 28 Joints) were negatively correlated with total INCAVISA. In multivariate analysis, DAS-28 and polypharmacy were independent predictors for a negative perception of HRQoL evaluated by INCAVISA in RA patients.

Conclusions
Disease activity and disability secondary to RA have a negative impact in the HRQoL. Other factors such as the number of drugs prescribed to these patients have been shown to be important for the negative perception of their HRQoL evaluated by INCAVISA.
Diagnostic Yield for Cancer and Diagnostic Accuracy of Computed Tomography–guided Core Needle Biopsy of Subsolid Pulmonary Lesions
Authors: Munir Sohaib , Koppikar Sahil , Hopman Wilma M. , Boag Alexander H. , Dhillon Gurmohan , Salahudeen Shafeequr Rahman , Nolan Robert L. , Flood Justin 
Published: November 2016

Purpose:
We aimed to determine the diagnostic yield for cancer and diagnostic accuracy of computed tomography–guided core needle biopsy (CTNB) in subsolid pulmonary lesions.

Materials and Methods:
Fifty-two biopsies of 52 subsolid lesions in 51 patients were identified from a database of 912 lung biopsies and analyzed for the diagnostic yield for cancer and diagnostic accuracy of core CTNB diagnosis as well as complication rates.

Results:
When indeterminate biopsy results were included in the analysis, the diagnostic yield for cancer was 80.8% and the diagnostic accuracy of core needle biopsy was 84.6% (n=52). It was 85.7% and 91.7%, respectively, when indeterminate results were excluded (n=48) and 82.4% and 82.4%, respectively, for biopsies with surgical confirmation (n=17). Attenuation was statistically significant for diagnostic yield for cancer (P=0.028) and diagnostic accuracy of core needle biopsy (P=0.001) when the indeterminate results were excluded (n=48). Attenuation and size were not statistically significant for diagnostic yield for cancer and diagnostic accuracy of needle biopsy (n=52), and size was not statistically significant for either when the indeterminate results were excluded. These results were achieved without any major complications as per the Society of Interventional Radiology Standards of Practice.

Conclusions:
CTNB offers a high yield in establishing a histopathologic diagnosis of subsolid pulmonary lesions, with both ground-glass and solid-predominance. The pure ground-glass category of lesions requires further research to determine the true diagnostic yield and diagnostic accuracy of core needle biopsies.
Identification of Novel and Noninvasive Biomarkers of Acute Cellular Rejection After Liver Transplantation by Protein Microarray
Authors: Okubo Keita , Wada Hiroshi , Tanaka Atsushi , Eguchi Hidetoshi , Hamaguchi Masahide , Tomokuni Akira , Tomimaru Yoshito , Asaoka Tadafumi , Hama Naoki , Kawamoto Koichi , Kobayashi Shogo , Marubashi Shigeru , Nagano Hiroaki , Sakaguchi Noriko , Nishikawa Hiroyoshi , Doki Yuichiro , Mori Masaki , Sakaguchi Shimon 
Published: November 2016

Background
Acute cellular rejection (ACR) is one of the main factors in transplanted organ failure in liver transplantation. A precise marker for diagnosing or predicting rejection is not currently available; therefore, invasive liver biopsy is standard procedure. To develop a noninvasive method for precise diagnosis of ACR, we evaluated autoantibodies from patient sera as potential biomarkers using protein microarrays (seromics).

Methods
Sera from hepatitis C virus–positive ACR patients were compared to three hepatitis C virus cirrhosis control groups and healthy volunteers. The control groups consisted of 2 no-ACR groups obtained on postoperative day 28 and 1 year after transplantation and a preoperative group obtained 1 day before transplantation. For validation, we evaluated whether the candidate antibodies can distinguish ACR from other types of liver dysfunction after liver transplantation using enzyme-linked immunosorbent assay.

Results
Seromic analysis by weighted average difference (WAD) ranking and Mann-Whitney U test revealed a significant increase of 57 autoantibodies in the sera of ACR patients with liver dysfunction. Among the 57 candidates, autoantibodies to charged multivesicular body protein 2B, potassium channel tetramerization domain containing 14, voltage gated subfamily A regulatory beta subunit 3, and triosephosphate isomerase 1 were regarded as potential biomarkers of ACR after liver transplantation. Using 20 ACR patients with variable backgrounds for validation, the autoantibodies to charged multivesicular body protein 2B and triosephosphate isomerase 1 were significantly increased in ACR patients compared to other control groups.

Conclusions
A panel of autoantibodies identified by seromics as potential noninvasive biomarkers was clinically useful for diagnosing ACR after liver transplantation.
Engineered reciprocal chromosome translocations drive high threshold, reversible population replacement in Drosophila
Authors: Buchman Anna B. , Ivy Tobin , Marshall John M. , Akbari Omar S. , Hay Bruce A. 
Published: November 2016

AbstractReplacement of wild insect populations with transgene-bearing individuals unable to transmit disease or survive under specific environmental conditions provides self-perpetuating methods of disease prevention and population suppression, respectively. Gene drive mechanisms that require the gene drive element and linked cargo exceed a high threshold frequency to spread are attractive because they offer several points of control: they bring about local, but not global population replacement; and transgenes can be eliminated by reintroducing wildtypes into the population so as to drive the frequency of transgenes below the threshold required for drive. It has long been recognized that reciprocal chromosome translocations could, in principal, be used to bring about high threshold gene drive through a form of underdominance. However, translocations able to drive population replacement have not been reported, leaving it unclear if translocation-bearing strains fit enough to mediate gene drive can easily be generated. Here we use modeling to identify a range of conditions under which translocations should spread, and the equilibrium frequencies achieved, given specific introduction frequencies, fitness costs and migration rates. We also report the creation of engineered translocation-bearing strains ofDrosophila melanogaster, generated through targeted chromosomal breakage and homologous recombination. By several measures translocation-bearing strains are fit, and drive high threshold, reversible population replacement in laboratory populations. These observations, together with the generality of the tools used to generate translocations, suggest that engineered translocations may be useful for controlled population replacement in many species.
Construction of a high-density American cranberry (Vaccinium macrocarponAit.) composite map using genotyping-by-sequencing for multi-pedigree linkage mapping
Authors: Schlautman Brandon , Covarrubias-Pazaran Giovanny , Diaz-Garcia Luis , Iorizzo Massmo , Polashock James , Grygleski Edward , Vorsa Nicholi , Zalapa Juan 
Published: November 2016

ABSTRACTThe American cranberry (Vaccinium macrocarponAit.) is a recently domesticated, economically important, fruit crop with limited molecular resources. New genetic resources could accelerate genetic gain in cranberry through characterization of its genomic structure and by enabling molecular-assisted breeding strategies. To increase the availability of cranberry genomic resources, genotyping-by-sequencing (GBS) was used to discover and genotype thousands of single nucleotide polymorphisms (SNPs) within three inter-related cranberry full-sib populations. Additional simple sequence repeat (SSR) loci were added to the SNP datasets and used to construct bin maps for the parents of the populations, which were then merged to create the first high-density cranberry composite map containing 6073 markers (5437 SNPs and 636 SSRs) on 12 linkage groups (LGs) spanning 1124 cM. Interestingly, higher rates of recombination were observed in maternal than paternal gametes. The large number of markers in common (mean of 57.3) and the high degree of observed collinearity (mean Pair-wise Spearman Rank Correlations > 0.99) between the LGs of the parental maps demonstrates the utility of GBS in cranberry for identifying polymorphic SNP loci that are transferable between pedigrees and populations in future trait-association studies. Furthermore, the high-density of markers anchored within the component maps allowed identification of segregation distortion regions, placement of centromeres on each of the 12 LGs, and anchoring of genomic scaffolds. Collectively, the results represent an important contribution to the current understanding of cranberry genomic structure and to the availability of molecular tools for future genetic research and breeding efforts in cranberry.
Changes in information environment and merger announcements
Authors: Balasubramnian Bhanu , Fuller Kathleen , Steigner Tanja 
Published: November 2016

Purpose
The purpose of this paper is to examine the impact of regulatory changes by the US Securities and Exchange Commission in 2000 on private information leakage prior to merger announcements.

Design/methodology/approach
Using a sample of 5,045 merger announcements between 1990 and 2008, the authors examine differences in information leakage between the pre- and post-regulation period merger announcements for acquirers using regression analysis.

Findings
The results suggest that regulatory changes have been effective in preventing private information leakage in merger announcements for large- and medium-sized firms, for high-tech firms, and for stock deals. The authors find that abnormal trading volume due to differences in information quality is reduced post-regulation for stock deals, high-tech firms, large- and medium-sized bidders, indicating less leakage of information after the new regulations. The authors find higher announcement returns post-regulation for the entire sample and for all subsamples except stock deals, small firms, and public targets. Higher announcement returns indicate that merger announcements are a greater surprise to the market due to a reduction in leaked private information after the regulatory changes.

Practical implications
The results have implications on future rule changes, on refinements of insider trading rules, regulation fair disclosure, and regulation M-A. The authors leave for future research why certain types of firms or deals are not impacted by regulatory changes.

Originality/value
Examine the effect of changes in information environment on merger announcements for acquirers because the impact likely has greater significance on acquirers than that on targets. Past studies have examined only targets.
The Janus Conference a decade later
Authors: Stoller Michael Edward 
Published: November 2016

Purpose
This paper aims to analyze and understand the changes in the academic library collection landscape since the Janus Conference in 2005.

Design/methodology/approach
This paper is reflective, reviewing the outcomes of the Janus Conference and providing a careful analysis of the library collection landscape that has evolved since.

Findings
Dramatic changes in both library funding and the organization of the scholarly environment have required significant changes to the way one thinks of the library collections and their relation with one another.

Originality/value
This paper provides a new perspective on the nature of the research librarian and his/her relationship to the building of library collections and the provision of access to them.
Factors affecting perceived level of virtuality in hybrid construction project teams (HCPTs)
Authors: Hosseini M. Reza , Chileshe Nicholas , Baroudi Bassam , Zuo Jian , Mills Anthony 
Published: November 2016

Purpose
Deploying hybrid construction project teams (HCPTs) in which the common pattern of interactions is a blend of face-to-face and virtual communications has been increasingly gaining momentum in the construction context. Evidence has demonstrated that effectiveness of HCPTs is affected by a perceived level of virtuality, i.e. the perception of distance and boundaries between members where teams shift towards working virtually as opposed to purely collocated teams. This study aims to provide an integrated model of the factors affecting perceived virtuality in HCPTs, to address the conspicuous absence of studies on virtuality in the construction context.

Design/methodology/approach
An a priori list of factors extracted from existing literature on virtuality was subjected to the scrutiny of 17 experts with experiences of working in HCPTs through semi-structured interviews. Nvivo 10 was deployed for analysing the interview transcripts.

Findings
The findings outline the factors affecting virtuality in HCPTs and map the patterns of their associations as an integrated model. This leads to discovering a number of novel factors, which exert moderating impacts upon perceived virtuality in HCPTs.

Practical implications
The findings assist managers and practitioners dealing with any form of HCPTs (including building information modelling-based networks and distributed design teams) in identifying the variables manipulating the effectiveness of their teams. This enables them of designing more effective team arrangements.

Originality/value
As the first empirical study on virtuality in the construction context, this paper contributes to the sphere by conceptualising and contextualising the concept of virtuality in the construction industry. The study presents a new typology for the factors affecting perceived virtuality by categorising them into predictors and moderators.