bluuebunny/crossref_metadata_2025_split huggingface dataset:
Selective attention gates the interactive crossmodal coupling between perceptual systems
Authors: Convento Silvia , Rahman Md. Shoaibur , Yau Jeffrey M. 
Published: October 2017

SummaryCortical sensory systems often activate in parallel, even when stimulation is experienced through a single sensory modality [1–3]. Critically, the functional relationship between co-activated cortical systems is unclear: Co-activations may reflect the interactive coupling between information-linked cortical systems or merely parallel but independent sensory processing. Here, we report causal evidence consistent with the hypothesis that human somatosensory cortex (S1), which co-activates with auditory cortex during the processing of vibrations and textures [4–9], interactively couples to cortical systems that support auditory perception. In a series of behavioural experiments, we used transcranial magnetic stimulation (TMS) to probe interactions between the somatosensory and auditory perceptual systems as we manipulated attention state. Acute manipulation of S1 activity using TMS impairs auditory frequency perception when subjects simultaneously attend to auditory and tactile frequency, but not when attention is directed to audition alone. Auditory frequency perception is unaffected by TMS over visual cortex thus confirming the privileged interactions between the somatosensory and auditory systems in temporal frequency processing [10–13]. Our results provide a key demonstration that selective attention can modulate the functional properties of cortical systems thought to support specific sensory modalities. The gating of crossmodal coupling by selective attention may critically support multisensory interactions and feature-specific perception.
Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer
Authors: Dunne Philip D. , Coleman Helen G. , Bankhead Peter , Alderdice Matthew , Gray Ronan T. , McQuaid Stephen , Bingham Victoria , Loughrey Maurice B. , James Jacqueline A. , McCorry Amy M. B. , Gilmore Alan , Holohan Caitriona , Klingbiel Dirk , Tejpar Sabine , Johnston Patrick G. , McArt Darragh G. , Di Nicolantonio Federica , Longley Daniel B. , Lawler Mark 
Published: October 2017

AbstractBackgroundBRAF mutation occurs in 8-15% of colon cancers (CC), and is associated with poor prognosis in metastatic disease. Compared to wild-type BRAF (BRAFWT) disease, stage II/III CC patients with BRAF mutant (BRAFMT) tumors have shorter overall survival after relapse; however, time-to-relapse is not significantly different. The aim of this investigation was to identify, and validate, novel predictors of relapse of stage II/III BRAFMT CC.Patients and methodsWe used gene expression data from a cohort of 460 patients (GSE39582) to perform a supervised classification analysis based on risk-of-relapse within BRAFMT stage II/III CC, to identify transcriptomic biomarkers associated with prognosis within this genotype. These findings were validated using immunohistochemistry in an independent population-based cohort of Stage II/III CC (n=691), applying Cox proportional hazards analysis to determine associations with survival.ResultsHigh gene expression levels of Bcl-xL, a key regulator of apoptosis, were associated with increased risk of relapse, specifically in BRAFMT tumors (HR=8.3, 95% CI 1.7-41.7), but not KRASMT/BRAFWT or KRASWT/BRAFWT tumors. High Bcl-xL protein expression in BRAFMT, untreated, stage II/III CC was confirmed to be associated with an increased risk of death in an independent cohort (HR=12.13, 95% CI 2.49-59.13). Additionally, BRAFMT tumors with high levels of Bcl-xL protein expression appeared to benefit from adjuvant chemotherapy (P for interaction =0.006), indicating the potential predictive value of Bcl-xL expression in this setting.ConclusionsThese findings provide evidence that Bcl-xL gene and/or protein expression identifies a poor prognostic subgroup of BRAFMT stage II/III CC patients, who may benefit from adjuvant chemotherapy.Key MessageUsing a combination of computational biology discovery and immunohistochemistry validation in independent patient cohorts, we show that high expression of the apoptosis regulator Bcl-xL is associated with disease relapse specifically within BRAF mutant stage II/III colon cancer.This data could enable tailored disease management to reduce relapse rates in the most aggressive subtype.
Learning to perform auditory discriminations from observation is efficient but less robust than learning from experience
Authors: Narula Gagan , Herbst Joshua , Hahnloser Richard H.R. 
Published: October 2017

AbstractSocial learning enables complex societies. However, it is largely unknown how insights obtained from observation compare with insights gained from trial-and-error, in particular in terms of their robustness. We use aversive reinforcement to train “experimenter” zebra finches to discriminate between auditory stimuli in the presence of an “observer” finch. We find that experimenters are slow to successfully discriminate the stimuli but immediately generalize their ability to a new set of similar stimuli. By contrast, observers subjected to the same task instantly discriminate the initial stimulus set, but require more time for successful generalization. Drawing upon machine learning insights, we suggest that observer learning has evolved to rapidly absorb sensory statistics without pressure to minimize neural resources, whereas learning from experience is endowed with a form of regularization that enables robust inference.
How Cognitive and Reactive Fear Circuits Optimize Escape Decisions in Humans
Authors: Qi Song. , Hassabis Demis. , Sun Jiayin , Guo Fangjian. , Daw Nathaniel , Mobbs Dean 
Published: October 2017

Flight initiation distance (FID), the distance at which an organism flees from an approaching threat, is an ecological metric of cost-benefit functions of escape decisions. We adapted the FID paradigm to investigate how fast or slow attacking ‘virtual predators’ constrain escape decisions. We show that rapid escape decisions rely on ‘reactive fear’ circuits in the periaqueductal gray and midcingulate cortex (MCC), while protracted escape decisions, defined by larger buffer zones, were associated with ‘cognitive fear’ circuits which include posterior cingulate cortex, hippocampus and the ventromedial prefrontal cortex, circuits implicated in strategic avoidance and behavioral flexibility. Using a Bayesian Decision Model, we further show that optimization of escape decisions under rapid flight were localized to the MCC, a region involved in adaptive motor control, while the hippocampus is implicated in optimizing decisions that update and control slower escape initiation. These results demonstrate an unexplored link between defensive survival circuits and their role in adaptive escape decisions.SignificanceHumans, like other animals, have evolved a set of circuits whose primary function is survival. In the case of predation, these circuits include ‘reactive fear’ circuits involved in fast and immediate escape decisions and ‘cognitive fear’ circuits that are involved in the conscious feeling of threat as well as slow strategic escape. Using neuroimaging combined with computational modeling, we support this differentiation of fear circuits by showing that fast escape decisions are elicited by the periaqueductal gray and MCC, regions involved in reactive flight. Conversely, slower escape decisions rely on the hippocampus, posterior cingulate cortex and prefrontal cortex, a circuit implicated in behavioral flexibility. These results support the role of the defensive survival circuitry in escape decisions and a separation of fear into reactive and cognitive circuits.
A most wanted list of conserved protein families with no known domains
Authors: Wyman Stacia K. , Avila-Herrera Aram , Nayfach Stephen , Pollard Katherine S. 
Published: October 2017

AbstractThe number and proportion of genes with no known function are growing rapidly. To quantify this phenomenon and provide criteria for prioritizing genes for functional characterization, we developed a bioinformatics pipeline that identifies robustly defined protein families with no annotated domains, ranks these with respect to phylogenetic breadth, and identifies them in metagenomics data. We applied this approach to 271 965 protein families from the SFams database and discovered many with no functional annotation, including >118 000 families lacking any known protein domain. From these, we prioritized 6 668 conserved protein families with at least three sequences from organisms in at least two distinct classes. These Function Unknown Families (FUnkFams) are present in Tara Oceans Expedition and Human Microbiome Project metagenomes, with distributions associated with sampling environment. Our findings highlight the extent of functional novelty in sequence databases and establish an approach for creating a “most wanted” list of genes to characterize.
Assembly and translocation of a CRISPR-Cas primed acquisition complex
Authors: Brown Maxwell W. , Dillard Kaylee E. , Xiao Yibei , Dolan Adam , Hernandez Erik , Dahlhauser Samuel , Kim Yoori , Myler Logan R. , Anslyn Eric , Ke Ailong , Finkelstein Ilya J. 
Published: October 2017

AbstractBacteria and archaea destroy foreign nucleic acids by mounting an RNA-based CRISPR-Cas adaptive immune response1–3. In type I CRISPR-Cas systems, the most frequently found type of CRISPR in bacteria and archaea3,4, foreign DNAs that trigger efficient immunity can also provoke primed acquisition of protospacers into the CRISPR locus5–12. Both interference and primed acquisition require Cascade (CRISPR-associated complex for antiviral defense) and the Cas3 helicase/nuclease. Primed acquisition also requires the Cas1-Cas2 integrase; however, the biophysical mechanisms of how interference and primed acquisition are coordinated have remained elusive. Here, we present single-molecule characterization of the type I-E Thermobifida fusca (Tfu) primed acquisition complex (PAC). TfuCascade rapidly samples non-specific DNA for its target via facilitated one-dimensional (1D) diffusion. An evolutionary-conserved positive patch on the Cse1 subunit increases the target recognition efficiency by promoting this 1D diffusion. Cas3 loads at target-bound Cascade and the Cascade/Cas3 complex initiates processive translocation via a looped DNA intermediate. Moving Cascade/Cas3 complexes stall and release the DNA loop at protein roadblocks. Cas1-Cas2 samples DNA transiently via 3D collisions, but stably associates with target-bound Cascade. Cas1-Cas2 also remains associated with translocating Cascade/Cas3, forming the PAC. By directly imaging all key subcomplexes involved in target recognition, interference, and primed acquisition, this work provides a molecular basis for the coordinated steps in CRISPR-based adaptive immunity.
Patanjali’s marketing mix: the monk’s new Ferrari
Authors: Agarwal Varun , Agrawalla Sweta 
Published: October 2017

Subject area
Marketing Management, Product & Brand Management, Entrepreneurship.

Study level/applicability
This case can be taught effectively to MBA/BBA students as part of Marketing Management, Product & Brand Management, Entrepreneurship.

Case overview
The case talks about the marketing mix strategy of India’s fastest growing fast moving consumer goods (FMCGs) brand Patanjali, with a tremendous revenue growth rate of 100 per cent for the past five years, leaving major FMCG companies insomniac. Patanjali Ayurved Limited riding on Baba Ramdev’s brand equity positioned itself as an authentic Ayurved brand with ancient Indian roots. Patanjali’s product line ranges from healthcare, personal care, home care, to food and more. Patanjali’s products were priced 10-40 per cent lower than that of its competitors. Run by franchisees, Patanjali had a three-tier distribution system. These included Patanjali Chikitsalayas which were franchise dispensaries and clinics along with doctors, Patanjali Arogya Kendra which were health and wellness centres and Swadeshi Kendra, non-medicine outlets. The company has 15,000 exclusive outlets across India and plans to grow to 1,00,000 exclusive outlets by 2020. Patanjali amazed the world by achieving phenomenal success without spending much on advertising in its nascent stage. Recently Patanjali adopted the multinational corporation (MNC) style of advertising by hiring two top advertising agencies McCann and DDB Mudra to prepare the company for the next phase of growth. Patanjali diversified into various segments of the market, ranging from FMCG products, Ayurvedic medicines, Ayurvedic hospitals and a medical college. Patanjali plans to enter various categories of products including the beauty products segment to compete with major MNCs, the baby care segment to compete with Johnson & Johnson, and the sports segment to compete with Nike and Adidas. Patanjali as a brand has a strong positioning in the minds of consumers as a natural and Ayurvedic brand. Will Patanjali’s foray into so many diversified segments lead to a brand extension trap and confused positioning? Because Patanjali as a brand, solely rides on Baba Ramdev’s image, if Baba Ramdev ever finds himself at the centre of a controversy, will Patanjali’s brand equity take a hit? Will it affect the brand Patanjali? Even if Baba Ramdev does not get into any controversy, what will happen to the brand Patanjali when Baba Ramdev is no more? Who should be the next face of Patanjali? Can the brand survive without a face?

Expected learning outcomes
The case is designed to enable students to understand the following key learning points: The concept of marketing mix. Product mix, Promotion mix branding (especially “Person as a Brand”), customer-based brand equity (CBBE) model or brand resonance pyramid.

Supplementary materials
Teaching Notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 8: Marketing.
Factors influencing the adoption of digital reference services among the university librarians in Pakistan
Authors: Khan Asad , Masrek Mohamad Noorman , Mahmood Khalid , Qutab Saima 
Published: October 2017

Purpose
This study aims to explore the factors affecting the adoption of digital reference services (DRS) among the university librarians in Pakistan.

Design/methodology/approach
Based on the adapted unified theory of acceptance and use of technology (UTAUT) model, the proposed study tested 12 hypothetical relationships through structural equation modelling (SEM) techniques. The study approach was quantitative based on a questionnaire distributed online to a sample of Pakistani university librarians and completed by 289 respondents. The questionnaire used in this study was developed from other validated instruments used in past empirical studies. Descriptive and inferential data analyses were performed through SPSS and AMOS for SEM.

Findings
The results revealed usefulness, ease of use and information and communication technology (ICT) skills as the significant predictors of the adoption of DRS. However, moderating influence of the demographic factors (age, gender and type of library) on the relationship of predictors with outcome variable was found insignificant. The findings of this study imply that individuals’ readiness for the adoption of DRS is present in the university libraries of Pakistan.

Originality/value
In the context of Pakistan, this study was the first attempt that investigated factors of the adoption of DRS at individual level. In addition, two new factors – namely, ICT skills and library type – were incorporated into the UTAUT model and were then evaluated in the Pakistani context. However, these two factors were found insignificant in influencing librarians towards the adoption of DRS. The intended study is equally useful for librarians in other countries in terms of understanding the factors that impact the effective adoption of DRS.
Factors affecting LIS Israeli students’ mobile phone use: an exploratory study
Authors: Aharony Noa 
Published: October 2017

Purpose
Although the mobile phone is a popular gadget, only a few studies have examined the relationships between personality characteristics and mobile phone use. This study aims to integrate and extend the literature by focusing on various personality characteristics and motivations to fully understand the influence of these variables on mobile phone use.

Design/methodology/approach
The research was conducted in Israel during the first semester of the 2015 academic year and encompassed 181 library and information science students. Participants were asked to complete the following questionnaires: personal details, mobile usage, motivation, self-disclosure and personality characteristics (openness to experience and extroversion and loneliness).

Findings
The most common use of students’ mobile phones is for mobile voice communication. Further, results show that the major factors that influence individual mobile phone use are motivation and the time spent using the phone. In addition, results indicate that personality characteristics have a large impact on mobile phone use as well, and that the dominant ones are openness to experience and self-disclosure.

Originality/value
The current study expands the scope of research about mobile phone use by examining the different functions provided by mobile phones within the context of personality characteristics as well as motivation. Further, mobile phones now not only serve as a means of communication but also have become a central means in students’ lives to access their social network system of choice, search for information and enjoy online leisure activities.
Information security behaviors of smartphone users in China: an empirical analysis
Authors: Zhang Xiao Juan , Li Zhenzhen , Deng Hepu 
Published: October 2017

Purpose
Understanding user behavior is increasingly critical for information security in the use of smartphones. There is, however, lack of empirical studies about the behavior of smartphone users for information security in China. The purpose of this paper is to present an empirical analysis of the behavior of smartphone users in China in relation to information security.

Design/methodology/approach
A review of the related literature is conducted, leading to the development of a questionnaire for investigating the behavior of smartphone users. An online survey of the smartphone users in China is conducted. The collected data are analyzed with the use of descriptive analysis and Pearson’s chi-square test to better understand the behavior of smartphone users on information security.

Findings
The paper shows that there are serious concerns about information security in the use of smartphones in China including the ignorance of security information in downloading and using applications, inadequate phone settings, inappropriate enabling of add-on utilities and lack of proper disaster recovery plans. The study also reveals that there is a significant difference between different groups of users on information security in smartphone use.

Research limitations/implications
This paper is based on a purposeful sample of smartphone users in China. It is exploratory in nature.

Practical implications
The paper can lead to a better understanding of the behavior of smartphone users and information security in China and provide relevant government departments and institutions with useful information for developing appropriate strategies and policies and designing specific training programs to improve information security in the smartphone use.

Originality/value
This paper is the first of this kind to collect quantitative data from users in China for better understanding the behavior of smartphone users on information security. It provides insight towards the adoption of various measures for information security from the perspective of smartphone users in China.
Ecosystem services in adaptation projects in West Africa
Authors: Muthee Kennedy Wahome , Mbow Cheikh , Macharia Geoffrey Mugo , Leal-Filho Walter 
Published: October 2017

Purpose
The purpose of this paper is to assess the extent to which adaptation projects have incorporated ecosystem services, as well as their redesigning options. The projects selected are listed under National Adaptation Programme of Action in West African region.

Design/methodology/approach
A desktop survey approach was used to review 168 projects from 13 countries across West Africa. The projects were categorized and analyzed according to their adaptation goal, thematic focus, their implementation duration and level of investment.

Findings
The adaptation initiatives are dominated by actions in the agricultural sector accounting for 32 per cent of the total. Further, they were characterized by small grants consideration with 63 per cent falling under US$1m budget, short-term implementation duration with 46 per cent having three years’ execution period. A large portion of projects (55 per cent) mentioned directly one or more ecosystem services, with provisioning services being referred to in 50 per cent of the cases.

Originality/value
Adaptation projects with ecosystem services components are more sustainable and beneficial to the community. Hence, more consideration of nature benefits during project design, more financial consideration and localizing of the projects to realize the global adaptation goal should be considered.
Design optimization of sustainable affordable housing model in hot-arid climate-case of Jordan
Authors: Ali Hikmat H. , Alzu’bi Shorouq N. 
Published: October 2017

Purpose
The aim of this paper is to study and evaluate the situation of different affordable housing projects with an eye toward developing a new affordable and sustainable housing model in the hot-arid climate of Jordan. There is a clear interest in providing affordable housing, yet sustainable and environmental issues are highly marginalized. To bridge this gap, and to meet Jordanian housing needs while tackling environmental problems, this research has analyzed the environmental issues of selected housing projects in Jordan, aiming to determine the existing problems. In addition, it proposes a solution through a sustainable and affordable housing model that was analyzed and compared to the previously studied housing projects.

Design/methodology/approach
A cross-sectional design strategy was adopted and a mixed design method was used. Information related to the physical and operation characteristics of buildings was collected through the review of “as built” drawings and other relevant documents. Further information was obtained from field surveys and personal interviews with architects and decision-makers in the housing sector. Energy consumption patterns of these housing projects were analyzed using the DesignBuilder simulation program. Water efficiency was assessed using the BRE Code Water Calculator. Based on the previous analysis, a new housing model was developed that was evaluated in terms of energy and water consumption.

Findings
The analysis shows a significant difference among different housing projects in terms of energy cooling and heating loads in different climatic regions in Jordan. Energy analysis proved that the proposed model is energy efficient in different locations and it can save up to 50.4 per cent of annual energy usage in comparison with existing projects. In addition, it can save around 43 per cent of water consumption by using a number of modifications for saving water.

Originality/value
Most of the housing initiatives focus on providing affordable housing, yet sustainable and environmental issues are highly marginalized. This research will bridge the gap by reducing the operation cost of affordable housing through adapting and implementing sustainable measures of design and construction.