bluuebunny/crossref_metadata_2025_split huggingface dataset:
HIF1α Counteracts TGFβ1-Driven TSP1 Expression in Endothelial Cells to Stimulate Angiogenesis in the Hypoxic Tumor Microenvironment
Authors: Luo Yu-Wei , Fang Yang , Zeng Hui-Xian , Ji Yu-Chen , Wu Meng-Zhi , Li Hui , Chen Jie-Ying , Zheng Li-Min , Fang Jian-Hong , Zhuang Shi-Mei 
Published: October 2024

Abstract
Emerging evidence suggests that TGFβ1 can inhibit angiogenesis, contradicting the coexistence of active angiogenesis and high abundance of TGFβ1 in the tumor microenvironment. Here, we investigated how tumors overcome the antiangiogenic effect of TGFβ1. TGFβ1 treatment suppressed physiologic angiogenesis in chick chorioallantoic membrane and zebrafish models but did not affect angiogenesis in mouse hepatoma xenografts. The suppressive effect of TGFβ1 on angiogenesis was recovered in mouse xenografts by a hypoxia-inducible factor 1α (HIF1α) inhibitor. In contrast, a HIF1α stabilizer abrogated angiogenesis in zebrafish, indicating that hypoxia may attenuate the antiangiogenic role of TGFβ1. Under normoxic conditions, TGFβ1 inhibited angiogenesis by upregulating antiangiogenic factor thrombospondin 1 (TSP1) in endothelial cells (EC) via TGFβ type I receptor (TGFβR1)–SMAD2/3 signaling. In a hypoxic microenvironment, HIF1α induced miR145 expression; miR145 abolished the inhibitory effect of TGFβ1 on angiogenesis by binding and repressing SMAD2/3 expression and subsequently reducing TSP1 levels in ECs. Primary ECs isolated from human hepatocellular carcinoma displayed increased miR145 and decreased SMAD3 and TSP1 compared with ECs from adjacent nontumor livers. The reduced SMAD3 or TSP1 in ECs was associated with increased angiogenesis in hepatocellular carcinoma tissues. Collectively, this study identified that TGFβ1–TGFβR1–SMAD2/3–TSP1 signaling in ECs inhibits angiogenesis. This inhibition can be circumvented by a hypoxia–HIF1α–miR145 axis, elucidating a mechanism by which hypoxia promotes angiogenesis.
Significance: Suppression of angiogenesis by TGFβ1 is mediated by TSP1 upregulation in endothelial cells and abrogated by HIF1α–miR145 activity in the hypoxic tumor microenvironment, providing potential targets to remodel the tumor vasculature.
Targeting the Epidermal Growth Factor Receptor Pathway in Chemotherapy-Resistant Triple-Negative Breast Cancer: A Phase II Study
Authors: Yam Clinton , Patel Miral , Hill Holly A. , Sun Ryan , Bassett Roland L. , Kong Elisabeth , Damodaran Senthil , Koenig Kimberly B. , Abouharb Sausan , Saleem Sadia , Bisen Ajit K. , Murthy Rashmi K. , Ramirez David L. , Rauch Gaiane M. , Adrada Beatriz E. , Candelaria Rosalind P. , Wang Xiaoping , Mittendorf Elizabeth A. , Thompson Alastair M. , White Jason B. , Ravenberg Elizabeth E. , Clayborn Alyson R. , Ding Qing-Qing , Booser Daniel J. , Oke Oluchi , Brewster Abenaa M. , Hortobagyi Gabriel N. , Ibrahim Nuhad K. , Litton Jennifer K. , Valero Vicente , Arun Banu K. , Tripathy Debu , Chang Jeffrey T. , Chen Ken , Korkut Anil , Moulder Stacy L. , Huo Lei , Lim Bora , Ueno Naoto T. 
Published: October 2024

Abstract

Purpose:
Epidermal growth factor receptor (EGFR) pathway activation causes chemotherapy resistance, and inhibition of the EGFR pathway sensitizes triple-negative breast cancer (TNBC) cells to chemotherapy in preclinical models. Given the high prevalence of EGFR overexpression in TNBC, we conducted a single-arm phase II study of panitumumab (anti-EGFR monoclonal antibody), carboplatin, and paclitaxel as the second phase of neoadjuvant therapy (NAT) in patients with doxorubicin and cyclophosphamide (AC)–resistant TNBC (NCT02593175).

Patients and Methods:
Patients with early-stage, AC-resistant TNBC, defined as disease progression or ≤80% reduction in tumor volume after four cycles of AC, were eligible for this study and received panitumumab (2.5 mg/kg i.v., every week × 13), paclitaxel (80 mg/m2 i.v. every week × 12), and carboplatin (AUC = 4 i.v., every 3 weeks × 4) as the second phase of NAT. A two-stage Gehan-type design was used to detect an improvement in the pathological complete response (pCR)/residual cancer burden class I (RCB-I) rate from 5% to 20%. Whole-exome sequencing was performed on diagnostic tumor biospecimens, where available.

Results:
From November 3, 2016, through August 23, 2021, 43 patients with AC-resistant TNBC were enrolled. The combined pCR/RCB-I rate was 30.2%. The most common treatment-related adverse events were neutropenia (72%) and anemia (61%), with 7 (16%), 16 (37%), and 8 (19%) patients experiencing grade 4 neutropenia, grade 3 neutropenia, and grade 3 anemia, respectively. No new safety signals were observed.

Conclusions:
This study met its primary endpoint (pCR/RCB-I = 30.2% vs. 5% in historical controls), suggesting that panitumumab should be evaluated as a component of NAT in patients with chemotherapy-resistant TNBC in a larger, randomized clinical trial.

Significance:
The epidermal growth factor receptor (EGFR) pathway has been implicated as a driver of chemotherapy resistance in triple-negative breast cancer (TNBC). Here, we evaluate the combination of panitumumab, carboplatin, and paclitaxel as the second phase of neoadjuvant therapy (NAT) in patients with AC-resistant TNBC. This study met its primary efficacy endpoint, and molecular alterations in EGFR pathway genes did not seem to influence response to the study regimen.
USP36 SUMOylates Las1L and Promotes Its Function in Pre–Ribosomal RNA ITS2 Processing
Authors: Li Yanping , Yang Yunhan , Sears Rosalie C. , Dai Mu-Shui , Sun Xiao-Xin 
Published: October 2024

Abstract

Ribosome biogenesis is a highly regulated cellular process requiring a large cohort of accessory factors to ensure the accurate production of ribosomes. Dysregulation of ribosome biogenesis is associated with the development of various human diseases, including cancer. The Las1L–Nol9 endonuclease–kinase complex is essential for the cleavage of the rRNA internal transcribed spacer 2 (ITS2), the phosphorylation of the 5′-hydroxyl end of the resulting precursor, and, thus, the maturation of the 60S ribosome. However, how the Las1L–Nol9 complex is regulated in cells is unclear. In this study, we report that the nucleolar ubiquitin-specific protease USP36 is a novel regulator of the Las1L–Nol9 complex. USP36 interacts with both Las1L and Nol9 and regulates their stability via deubiquitination. Intriguingly, USP36 also mediates the SUMOylation of Las1L, mainly at lysine (K) 565. Mutating K565 to arginine (R) does not affect the levels of Las1L and the formation of the Las1L–Nol9 complex, but abolishes its function in ITS2 processing, as unlike wild-type Las1L, the K565R mutant failed to rescue the defects in the ITS2 processing induced by the knockdown of endogenous Las1L. These results suggest that USP36-mediated Las1L SUMOylation is critical for ITS2 processing and that USP36 plays a critical role in ribosome biogenesis by regulating the Las1L–Nol9 complex.

Significance:
This study identifies USP36 as a deubiquitinating and small ubiquitin-like modifier ligase dual-function enzyme to mediate Las1L deubiquitination and SUMOylation. Las1L SUMOylation at K565 plays a critical role in pre-rRNA ITS2 processing. Thus, our study reveals a novel downstream pathway for USP36-regulated ribosome biogenesis.
Perfil epidemiológico, sobrevida e prognóstico materno em unidade de terapia intensiva no nordeste do Brasil
Authors: Santos Júnior José Arimatéa dos , Francisco Rossana Pulcineli Vieira , Armstrong Bruna Benigna Sales , Vale Vinícius Araújo do 
Published: October 2024

Objective. To study the epidemiologic profile and determine maternal survival and prognosis in an Intensive Care Unit (ICU) in the Northeast of the country. Methods. Analytical cross-sectional design study that evaluated pregnant women, puerperae, and women in postabortion or ectopic pregnancy admitted to an obstetric ICU in Teresina between May/2016 and May/2017. Results. Of the 11,466 occurrences in the period, 456 women were admitted to the ICU. Among the causes of hospitalization, 80.3% patients were direct obstetric causes, 16.2% indirect and 3.5% non-obstetric. A total of 159 patients met the Near Miss criteria, with statistical significance between presentation of the criteria and mortality (p<0.001; x²=30.974). The mortality rate was 3.5%, all of them being Near Miss cases. There was a statistically significant and direct correlation between survival and number of clinical (p<0.001; rp=0.270), laboratory (p<0.001; rp=0.358) and management (p<0.001; rp=0.465) criteria. It was identified that the higher the number of criteria, the longer the length of hospitalization and worse the prognosis (p<0.001). Conclusion. Women admitted to the ICU for indirect obstetric causes who met maternal Near Miss criteria had longer hospitalization and worse prognosis.
Effects of Catheter-Based Renal Denervation in Hypertension: A Systematic Review and Meta-Analysis
Authors: Vukadinović Davor , Lauder Lucas , Kandzari David E. , Bhatt Deepak L. , Kirtane Ajay J. , Edelman Elazer R. , Schmieder Roland E. , Azizi Michel , Böhm Michael , Mahfoud Felix 
Published: October 2024

BACKGROUND:
Several sham-controlled trials have investigated the efficacy and safety of catheter-based renal denervation (RDN) with mixed outcomes. We aimed to perform a comprehensive meta-analysis of all randomized, sham-controlled trials investigating RDN with first- and second-generation devices in hypertension.

METHODS:
We searched MEDLINE and the Cochrane Library for eligible trials. Outcomes included both efficacy (24-hour and office systolic [SBP] and diastolic blood pressure [DBP]) and safety (all-cause death, vascular complication, renal artery stenosis >70%, hypertensive crisis) of RDN. We performed a study-level, pairwise, random-effects meta-analysis of the summary data.

RESULTS:

Ten trials comprising 2478 patients with hypertension while being either off or on treatment were included. Compared with sham, RDN reduced 24-hour and office systolic blood pressure by 4.4 mm Hg (95% CI, 2.7 to 6.1;
P
<0.00001) and 6.6 mm Hg (95% CI, 3.6 to 9.7;
P
<0.0001), respectively. The 24-hour and office diastolic blood pressure paralleled these findings (–2.6 mm Hg [95% CI, –3.6 to –1.5];
P
<0.00001; –3.5 mm Hg [95% CI, –5.4 to –1.6];
P
=0.0003). There was no difference in 24-hour and office systolic blood pressure reduction between trials with and without concomitant antihypertensive medication (
P
for interaction, 0.62 and 0.73, respectively). There was no relevant difference in vascular complications (odds ratio, 1.69 [95% CI, 0.57 to 5.0];
P
=0.34), renal artery stenosis (odds ratio, 1.50 [95% CI, 0.06 to 36.97];
P
=0.80), hypertensive crisis (odds ratio, 0.65 [95% CI, 0.30 to 1.38];
P
=0.26), and all-cause death (odds ratio, 1.76 [95% CI, 0.34 to 9.20];
P
=0.50) between RDN and sham groups. Change of renal function based on estimated glomerular filtration rate was comparable between groups (
P
for interaction, 0.84). There was significant heterogeneity between trials.

CONCLUSIONS:
RDN safely reduces ambulatory and office systolic blood pressure/diastolic blood pressure versus a sham procedure in the presence and absence of antihypertensive medications.
Morphological and molecular characterisation of Bursaphelenchus parasaudi n. sp. (Tylenchina: Aphelenchoididae) found in loblolly pine logs from the USA
Authors: Gu Jianfeng , Fang Yiwu , Ma Xinxin 
Published: October 2024

Summary
Bursaphelenchus parasaudi n. sp., isolated in Ningbo, P.R. China, from loblolly pine logs imported from the USA is described. It is characterised by a slim body (a = 32-43), lateral field with four lines, excretory pore located at the level of metacorpus, vulva at 76% of total body length, a distinct vulval flap in lateral view, post-uterine branch ca half to two-thirds of the vulva to anus distance long, female tail conical, slightly ventrally curved, with a finely rounded terminus, male spicules with weakly developed rostrum and condylus and cross-striped in their central part, a single precloacal papilla and three pairs of ventro-sublateral papillae. It belongs to the africanus group of the genus Bursaphelenchus and is most similar to B. saudi. Detailed phylogenetic analysis based on the partial 18S region, ITS and 28S D2-D3 region confirmed the status of this nematode as a new species.
Stellarium corone benedicte Marie Virginis by Pelbart of Temesvar as a Source for Baltazar Opec’s Life of Lord Jesus Christ
Authors: Stelmach Wojciech 
Published: October 2024

Abstract
Baltazar Opec’s Life of Lord Jesus Christ (Żywot Pana Jezu Krysta) is one of the New Testament apocrypha written in Old Polish. Among the works identified as its sources are Meditationes vitae Christi, Speculum passionis, and Vita rhythmica. It has recently been established, however, that the basis for the translation of the final chapters of Opec’s work was a part of the compilation of sermons Stellarium corone benedicte Marie Virginis by Pelbart of Temesvar. In this article I verify and develop the initial theses of Roman Mazurkiewicz concerning the translator’s work with the source text. I indicate ways in which the Old Polish author worked with the Latin sermons, and discuss rhetorical elements present in ŻPJK that may be traced back to Pelbart’s text.
Characterisation of potential anti-inflammatory next-generation probiotics resistant to bisphenol A
Authors: López-Moreno A. , Carbonne C. , Kropp C. , Rios-Covian D. , Pepke F. , Langella P. , Aguilera M. , Martin R. 
Published: October 2024

Abstract
The world is witnessing an increasing incidence of chronic non-communicable diseases (NCDs), such as inflammatory bowel disease (IBD), a group of complex gastrointestinal disorders characterised by inflammation. It is believed that environmental factors, such as exposure to pollutants and endocrine-disrupting chemicals (i.e. bisphenol A [BPA]), are playing a role in IBD pathophysiology. New research suggests a potential treatment solution: next-generation probiotic (NGP) strains isolated from human gut microbiota that can biodegrade xenobiotics and thus possibly modulate IBD triggered by these xenobiotics. In this study, we hypothesised that specific BPA-tolerant bacteria would exhibit beneficial, anti-inflammatory properties that could counter the effects of BPA exposure and concomitantly reduce colitis severity. We observed that two such strains, Bacillus sp. AM1 and Paeniclostridium sp., exhibited potential anti-inflammatory properties in vitro and in vivo. First, these bacteria were able to decrease the secretion of interleukin (IL)-8 cytokines by HT-29 cells that had been exposed to the proinflammatory cytokine tumour necrosis factor (TNF)-α. Second, when treated with Bacillus sp. AM1 and Paeniclostridium sp. (this latter had a stronger reducing effect on inflammatory markers), mice with chemically induced colitis displayed lower levels of colon damage, monocyte chemotactic protein 1 (MCP-1), lipocalin-2 (LCN-2), and proinflammatory cytokines (IL-1β and IL-6). Future research should clarify the underlying mechanisms at play and identify potential strategies for counteracting the systemic effects of IBD, including those exacerbated by BPA exposure. Our results suggest that one such strategy could be treatment with BPA-tolerant bacteria that possess anti-inflammatory properties.
Maternity and the Armed Struggle in the Global South
Authors: Asunción-Criado Ana , Díaz Sánchez Pilar 
Published: October 2024

Abstract
Studies on the participation of women in guerrilla conflicts suffer from an in-depth study of the key aspects of women’s lives, such as motherhood and relations between the sexes. The analysis focuses on the Central and South American guerrilla movements, although open to a comparative study with organizations from other geographical spaces. In these pages these issues are analyzed to consider to what extent the revolutionary objectives that in economic and political aspects are maximalist, forget to question the issue of motherhood and the co-responsibility for the maintenance of offspring that continues to fall exclusively on women. Using the testimonies of the guerrilla women, the helplessness of women in the guerrilla environment, the abuses and the situation of subjugation and inequality in relations between the sexes is observed.
Bulgarian Poetry about the Past and the Post-Socialist Present
Authors: Jóźwiak Wojciech 
Published: October 2024

Bulgarian Poetry about the Past and the Post-Socialist Present
This article is a review of the study entitled Pamięć kulturowa a symptomy traumy. Idea ojczyzny w liryce bułgarskiej po 1989 roku [Cultural Memory and Symptoms of Trauma: The Idea of Homeland in Bulgarian Poetry after 1989], authored by Dorota Gołek-Sepetliewa (Katowice: Wydawnictwo Uniwersytetu Śląskiego, 2023, pp. 389).

Liryka bułgarska o przeszłości i postsocjalistycznej współczesności
Recenzja monografii naukowej Pamięć kulturowa a symptomy traumy. Idea ojczyzny w liryce bułgarskiej po 1989 roku, autorstwa Doroty Gołek-Sepetliewej (Katowice: Wydawnictwo Uniwersytetu Śląskiego, 2023, 389 ss.).
Aggregation–Disaggregation Cycles in ERA5 Reanalysis
Authors: Maithel Vijit , Back Larissa 
Published: October 2024

Abstract
Understanding convective aggregation is very important for understanding tropical climate and climate sensitivity. However, we still lack a full understanding of how aggregation evolves in the real world or what phenomena and scales are analogous to the self-aggregation observed in idealized models. In this study, we apply the moist static energy (MSE) variance budget framework to ERA5 reanalysis data to study the evolution of large-scale aggregation over tropical oceans at basinwide scales. Our novel phase space diagnostics focus on the variability of observed aggregation compared to most previous self-aggregation studies, which focus more on the aggregated mean state. We visualize observed aggregation to evolve anomalously around a mean state in a cyclical fashion forming aggregation–disaggregation cycles. We find horizontal advection of MSE to play the primary role in determining when the domain aggregates or disaggregates. In contrast, all advective, radiative, and surface flux feedbacks are found important for determining the magnitude of the aggregation anomalies. Surface fluxes and horizontal advection tend to dampen aggregation anomalies, while radiative fluxes and vertical advection tend to amplify aggregation anomalies. Looking deeper into the advection terms, we find that changes in vertical advection are dominated by enhanced low-level subsidence over the dry regions during the more aggregated states. This creates an anomalous drying tendency over the dry regions, which maintains aggregation anomalies. In contrast, horizontal advection changes are found to be dominated by increased moisture advection out of the moist columns with stronger aggregation.

Significance Statement
The purpose of this study is to characterize and understand the evolution of large-scale convective aggregation in the real world through reanalysis data. While most previous observational studies have focused on the evolution of clouds and cloud populations with aggregation, we focus on the energetics and the impact of aggregation on redistributing moisture throughout the domain. Our framework highlights that aggregation can be visualized as a continuously occurring cyclic feature at large scales in the tropics. Further, our work provides a deeper insight into the changes in large-scale circulation that accompany aggregation and characterizes the similarities and differences between the different regions in the tropics.
Quality of Life After Pediatric Tympanomastoidectomy
Authors: Lovin Benjamin D. , Nguyen Aaron C. , Lindquist Nathan R. , Nguyen Duc , Silva Rodrigo , Sweeney Alex D. 
Published: October 2024

Objectives: To assess quality of life (QOL) outcomes after canal wall up (CWU) and canal wall down (CWD) tympanomastoidectomy in the pediatric population. Methods: A retrospective review tabulated pediatric patients undergoing CWU and CWD tympanomastoidectomy for cholesteatoma by 2 senior surgeons at a single tertiary academic referral center between March 2017 and March 2023. Chronic Ear Survey (CES) and cosmetic survey outcomes were collected post-operatively. Results: A total of 77 ears in 75 patients were identified, with 35 undergoing CWU and 42 undergoing CWD as the most recent (index) otologic surgery. Seventeen patients (23%) participated in the survey. Of this cohort, the mean age was 14.6 years, 12 (71%) were male, and 10 (59%) had CWD as the most recent otologic surgery. The mean time from index surgery to survey completion was 3.4 years (range, 0.1-6.7 years). Regarding QOL outcomes, there were no statistically significant differences in total CES score, CES subscores, and cosmetic survey scores between groups when categorizing by gender or index surgery. Total CES, symptom subscale, medical resource subscale, and cosmetic survey scores showed a tendency to decrease with an increasing number of surgeries ( R = −.18, −.28, −.53, and −.56, respectively). Pediatric total CES scores appeared comparable to those reported in the published adult literature. Conclusions: It does not appear that there are worse QOL outcomes for pediatric patients who undergo CWD tympanomastoidectomy compared to those who undergo CWU tympanomastoidectomy. There appears to be no difference in QOL outcomes between pediatric and adult patients undergoing tympanomastoidectomy.
A Narrative Review on the Impact of Teachers’ Support in the Prevention of Death by Suicide Among Young People
Authors: Borah Kallabi , Jose Tessy Treesa , Nagaraj Anil Kumar Mysore , George Linu Sara 
Published: October 2024

Background: Death by suicide among young people is a growing issue worldwide. Every year, 46000 children (10–19 years old) take their lives. Lack of social support is one of the causes of suicide in young people. This narrative review aims to highlight the impact of teachers’ support in the prevention of death by suicide among young people. Methods: A literature search was conducted in Scopus, PubMed, Embase, and Web of Science to find out the relevant studies using the keywords and synonyms of “social support,” “young,” “suicide,” and “teacher.” The original articles published in indexed and peer-reviewed English language journals in the last 10 years (2014–2023) were included in this review. The included articles were focused on teachers’ support in terms of the prevention of suicide among young people. Results: After screening the title-abstract and full-text articles, the review findings revealed that support from teachers has a positive impact on the prevention of suicide among young people. Young people who have higher teachers’ support show lower suicidal behaviors. Hence, teachers’ support acts as a protective factor against suicide in young people. Conclusion: The review concludes that teachers’ support has shown a positive impact on reducing suicidal behaviors among young people. Teachers are important sources of support in understanding suicidal behaviors in young people. Holistic support from each one of us is the enormous need to reduce the number of suicides. Studies have recommended that teachers’ support should be the focus of intervention, for example, school-based psychoeducation on young people’s suicide.