bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tunable Multifunctional Thermal Metamaterials: Manipulation of Local Heat Flux via Assembly of Unit-Cell Thermal Shifters
Authors: Park Gwanwoo , Kang Sunggu , Lee Howon , Choi Wonjoon 
Published: January 2017

AbstractThermal metamaterials, designed by transformation thermodynamics are artificial structures that can actively control heat flux at a continuum scale. However, fabrication of them is very challenging because it requires a continuous change of thermal properties in materials, for one specific function. Herein, we introduce tunable thermal metamaterials that use the assembly of unit-cell thermal shifters for a remarkable enhancement in multifunctionality as well as manufacturability. Similar to the digitization of a two-dimensional image, designed thermal metamaterials by transformation thermodynamics are disassembled as unit-cells thermal shifters in tiny areas, representing discretized heat flux lines in local spots. The programmed-reassembly of thermal shifters inspired by LEGO enable the four significant functions of thermal metamaterials—shield, concentrator, diffuser, and rotator—in both simulation and experimental verification using finite element method and fabricated structures made from copper and PDMS. This work paves the way for overcoming the structural and functional limitations of thermal metamaterials.
The systematic analysis of coding and long non-coding RNAs in the sub-chronic and chronic stages of spinal cord injury
Authors: Duran Raquel Cuevas-Diaz , Yan Han , Zheng Yiyan , Huang Xingfan , Grill Raymond , Kim Dong H. , Cao Qilin , Wu Jia Qian 
Published: January 2017

AbstractSpinal cord injury (SCI) remains one of the most debilitating neurological disorders and the majority of SCI patients are in the chronic phase. Previous studies of SCI have usually focused on few genes and pathways at a time. In particular, the biological roles of long non-coding RNAs (lncRNAs) have never been characterized in SCI. Our study is the first to comprehensively investigate alterations in the expression of both coding and long non-coding genes in the sub-chronic and chronic stages of SCI using RNA-Sequencing. Through pathway analysis and network construction, the functions of differentially expressed genes were analyzed systematically. Furthermore, we predicted the potential regulatory function of non-coding transcripts, revealed enriched motifs of transcription factors in the upstream regulatory regions of differentially expressed lncRNAs, and identified differentially expressed lncRNAs homologous to human genomic regions which contain single-nucleotide polymorphisms associated with diseases. Overall, these results revealed critical pathways and networks that exhibit sustained alterations at the sub-chronic and chronic stages of SCI, highlighting the temporal regulation of pathological processes including astrogliosis. This study also provided an unprecedented resource and a new catalogue of lncRNAs potentially involved in the regulation and progression of SCI.
Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses
Authors: Bazhanov Nikolay , Escaffre Olivier , Freiberg Alexander N. , Garofalo Roberto P. , Casola Antonella 
Published: January 2017

AbstractHydrogen sulfide is an important endogenous mediator that has been the focus of intense investigation in the past few years, leading to the discovery of its role in vasoactive, cytoprotective and anti-inflammatory responses. Recently, we made a critical observation that H2S also has a protective role in paramyxovirus infection by modulating inflammatory responses and viral replication. In this study we tested the antiviral and anti-inflammatory activity of the H2S slow-releasing donor GYY4137 on enveloped RNA viruses from Ortho-, Filo-, Flavi- and Bunyavirus families, for which there is no FDA-approved vaccine or therapeutic available, with the exception of influenza. We found that GYY4137 significantly reduced replication of all tested viruses. In a model of influenza infection, GYY4137 treatment was associated with decreased expression of viral proteins and mRNA, suggesting inhibition of an early step of replication. The antiviral activity coincided with the decrease of viral-induced pro-inflammatory mediators and viral-induced nuclear translocation of transcription factors from Nuclear Factor (NF)-kB and Interferon Regulatory Factor families. In conclusion, increasing cellular H2S is associated with significant antiviral activity against a broad range of emerging enveloped RNA viruses, and should be further explored as potential therapeutic approach in relevant preclinical models of viral infections.
Anisotropic hydrogen diffusion in α-Zr and Zircaloy predicted by accelerated kinetic Monte Carlo simulations
Authors: Zhang Yongfeng , Jiang Chao , Bai Xianming 
Published: January 2017

AbstractThis report presents an accelerated kinetic Monte Carlo (KMC) method to compute the diffusivity of hydrogen in hcp metals and alloys, considering both thermally activated hopping and quantum tunneling. The acceleration is achieved by replacing regular KMC jumps in trapping energy basins formed by neighboring tetrahedral interstitial sites, with analytical solutions for basin exiting time and probability. Parameterized by density functional theory (DFT) calculations, the accelerated KMC method is shown to be capable of efficiently calculating hydrogen diffusivity in α-Zr and Zircaloy, without altering the kinetics of long-range diffusion. Above room temperature, hydrogen diffusion in α-Zr and Zircaloy is dominated by thermal hopping, with negligible contribution from quantum tunneling. The diffusivity predicted by this DFT + KMC approach agrees well with that from previous independent experiments and theories, without using any data fitting. The diffusivity along <c> is found to be slightly higher than that along <a>, with the anisotropy saturated at about 1.20 at high temperatures, resolving contradictory results in previous experiments. Demonstrated using hydrogen diffusion in α-Zr, the same method can be extended for on-lattice diffusion in hcp metals, or systems with similar trapping basins.
Norovirus P particle-based active Aβ immunotherapy elicits sufficient immunogenicity and improves cognitive capacity in a mouse model of Alzheimer’s disease
Authors: Fu Lu , Li Yingnan , Hu Yue , Zheng Yayuan , Yu Bin , Zhang Haihong , Wu Jiaxin , Wu Hui , Yu Xianghui , Kong Wei 
Published: January 2017

AbstractDisease-modifying immunotherapies focusing on reducing amyloid-beta (Aβ) deposition are the main treatment for Alzheimer’s disease (AD). However, none of the Aβ immunotherapies has produced clinically meaningful results to date. The main reason for this lack of efficacy is that the vaccine induces insufficiently high antibody titers, as it contains small B-cell epitope of Aβ to avoid Aβ42-specific T-cell activation. With the aim of generating a potent AD vaccine, we designed the protein PP-3copy-Aβ1-6-loop123, comprising three copies of Aβ1-6 inserted into three loops of a novel vaccine platform, the norovirus P particle, which could present Aβ at its surface and remarkably enhance the immunogenicity of the vaccine. We demonstrated that PP-3copy-Aβ1-6-loop123 was able to elicit high antibody titers against Aβ42, without causing T-cell activation, in AD mice regardless of their age. Importantly, PP-3copy-Aβ1-6-loop123 treatment successfully reduced amyloid deposition, rescued memory loss, and repaired hippocampus damage in AD mice. The Aβ antibodies induced by this active immunotherapy reacted with and disrupted aggregated Aβ, reducing its cellular toxicity. In addition, our results suggested PP-3copy-Aβ1-6-loop123 immunization could restore Aβ42 homeostasis in both the serum and brain. Thus, the P particle-based Aβ epitope vaccine is a sufficiently immunogenic and safe immunotherapeutic intervention for Alzheimer’s disease.
Spatio-Temporal Tolerance of Visuo-Tactile Illusions in Artificial Skin by Recurrent Neural Network with Spike-Timing-Dependent Plasticity
Authors: Pitti Alexandre , Pugach Ganna , Gaussier Philippe , Shimada Sotaro 
Published: January 2017

AbstractPerceptual illusions across multiple modalities, such as the rubber-hand illusion, show how dynamic the brain is at adapting its body image and at determining what is part of it (the self) and what is not (others). Several research studies showed that redundancy and contingency among sensory signals are essential for perception of the illusion and that a lag of 200–300 ms is the critical limit of the brain to represent one’s own body. In an experimental setup with an artificial skin, we replicate the visuo-tactile illusion within artificial neural networks. Our model is composed of an associative map and a recurrent map of spiking neurons that learn to predict the contingent activity across the visuo-tactile signals. Depending on the temporal delay incidentally added between the visuo-tactile signals or the spatial distance of two distinct stimuli, the two maps detect contingency differently. Spiking neurons organized into complex networks and synchrony detection at different temporal interval can well explain multisensory integration regarding self-body.
Cold spells and ischaemic sudden cardiac death: effect modification by prior diagnosis of ischaemic heart disease and cardioprotective medication
Authors: Ryti Niilo R. I. , Mäkikyrö Elina M. S. , Antikainen Harri , Junttila M. Juhani , Hookana Eeva , Ikäheimo Tiina M. , Kortelainen Marja-Leena , Huikuri Heikki V. , Jaakkola Jouni J. K. 
Published: January 2017

AbstractSudden cardiac death (SCD) is the leading cause of death. The current paradigm in SCD requires the presence of an abnormal myocardial substrate and an internal or external transient factor that triggers cardiac arrest. Based on prior mechanistic evidence, we hypothesized that an unusually cold weather event (a cold spell) could act as an external factor triggering SCD. We tested potential effect modification of prior diagnoses and select pharmacological agents disrupting pathological pathways between cold exposure and death. The home coordinates of 2572 autopsy-verified cases of ischaemic SCD aged ≥35 in the Province of Oulu, Finland, were linked to 51 years of home-specific weather data. Based on conditional logistic regression, an increased risk of ischaemic SCD associated with a cold spell preceding death (OR 1.49; 95% CI: 1.06–2.09). Cases without a prior diagnosis of ischaemic heart disease seemed more susceptible to the effects of cold spells (OR 1.70; 95% CI: 1.13–2.56) than cases who had been diagnosed during lifetime (OR 1.14; 95% CI: 0.61–2.10). The use of aspirin, β-blockers, and/or nitrates, independently and in combinations decreased the risk of ischaemic SCD during cold spells. The findings open up new lines of research in mitigating the adverse health effects of weather.
Effects of Sr-HT-Gahnite on osteogenesis and angiogenesis by adipose derived stem cells for critical-sized calvarial defect repair
Authors: Wang Guifang , Roohani-Esfahani Seyed-Iman , Zhang Wenjie , Lv Kaige , Yang Guangzheng , Ding Xun , Zou Derong , Cui Daxiang , zreiqat Hala , Jiang Xinquan 
Published: January 2017

AbstractTissue engineering strategies to construct vascularized bone grafts are now attracting much attention. Strontium-hardystonite-Gahnite (Sr-HT-Gahnite) is a strong, highly porous, and biocompatible calcium silicate based bio-ceramic that contains strontium and zinc ions. Adipose derived stem cells (ASCs) have been demonstrated to have the ability in promoting osteogenesis and angiogenesis. In this study, the effects of Sr-HT-Gahnite on cell morphology, cell proliferation, and osteogenic differentiation of ASCs were systematically investigated. The cell proliferation, migration and angiogenic differentiation of human umbilical vein endothelial cell (HUVECs) were studied. Beta-tricalcium phosphate/hydroxyapatite (TCP/HA) bioceramic scaffolds were set as the control biomaterial. Both bio-ceramics exhibited no adverse influence on cell viability. The Sr-HT-Gahnite scaffolds promoted cell attachment and alkaline phosphatase (ALP) activity of ASCs. The Sr-HT-Gahnite dissolution products enhanced ALP activity, matrix mineralization, and angiogenic differentiation of ASCs. They could also improve cell proliferation, migration, and angiogenic differentiation of HUVECs. Levels of in vivo bone formation with Sr-HT Gahnite were significantly higher than that for TCP/HA. The combination of Sr-HT-Gahnite and ASCs promoted both osteogenesis and angiogenesis in vivo study, compared to Sr-HT-Gahnite and TCP/HA bio-ceramics when administered alone, suggesting Sr-HT-Gahnite can act as a carrier for ASCs for construction of vascularized tissue-engineered bone.
Bi-axial grown amorphous MoSx bridged with oxygen on r-GO as a superior stable and efficient nonprecious catalyst for hydrogen evolution
Authors: Lee Cheol-Ho , Yun Jin-Mun , Lee Sungho , Jo Seong Mu , Eom KwangSup , Lee Doh C. , Joh Han-Ik , Fuller Thomas F. 
Published: January 2017

AbstractAmorphous molybdenum sulfide (MoSx) is covalently anchored to reduced graphene oxide (r-GO) via a simple one-pot reaction, thereby inducing the reduction of GO and simultaneous doping of heteroatoms on the GO. The oxygen atoms form a bridged between MoSx and GO and play a crucial role in the fine dispersion of the MoSx particles, control of planar MoSx growth, and increase of exposed active sulfur sites. This bridging leads to highly efficient (−157 mV overpotential and 41 mV/decade Tafel slope) and stable (95% versus initial activity after 1000 cycles) electrocatalyst for hydrogen evolution.
Specific
characteristics of hemorrhagic Meckel’s diverticulum at double-balloon
endoscopy
Authors: Mizutani Yasuyuki , Nakamura Masanao , Watanabe Osamu , Yamamura Takeshi , Funasaka Kohei , Ohno Eizaburo , Kawashima Hiroki , Miyahara Ryoji , Murino Alberto , Goto Hidemi , Hirooka Yoshiki 
Published: January 2017

Abstract
Background and study aims Diagnosis of Meckel’s diverticulum (MD) before
surgery may be challenging; double-balloon endoscopy (DBE) facilitates
identification of MD in the setting of a gastrointestinal bleeding; however, MD
can be found incidentally without this condition. The purpose of this research
was to determine specific characteristic of hemorrhagic MD and incidental MD at
DBE.
Patients and methods Ectopic gastric mucosa enclosed in the MD and/or
ulceration were defined as “major findings”; ring-like scar surrounding the MD
was defined as “minor finding”. We retrospectively reviewed the medical records
of patients affected by MD and analyzed the findings that significantly affected
the characterization of MD.
Results MD was diagnosed in 33 patients. The axis of the diverticulum was
longer in hemorrhagic MD compared to incidental MD (P = 0.031). The
amount of transfusion was significantly higher (P = 0.018) in the
hemorrhagic MD group. Hemorrhagic MD was significantly more correlated with
major findings (P = 0.01) and minor findings (P < 0.01). The
specificity of major finding was 100 % while the sensitivity of major and/or
minor findings was 96 %.
Conclusions The combination of major and minor findings appears to improve
the diagnostic ability of hemorrhagic MD avoiding unnecessary
diverticulectomy.
Intra-channel stent release technique for fluoroless endoscopic ultrasound-guided lumen-apposing metal stent placement: changing the paradigm
Authors: Anderloni Andrea , Attili Fabia , Carrara Silvia , Galasso Domenico , Di Leo Milena , Costamagna Guido , Repici Alessandro , Kunda Rastislav , Larghi Alberto 
Published: January 2017

Abstract
Background Recently, a novel lumen-apposing fully covered self-expanding metal stent (LA-FCSEMS) mounted on an electrocautery-enhanced delivery system has been developed to perform endoscopic ultrasound (EUS)-guided transluminal drainage. From early experience, however, release of the proximal flange of the stent has mostly been done using endoscopic view guidance to ensure proper positioning.
Aim We describe a new technique that we have named the Intra-Channel Stent Release Technique (ICSRT) to perform stent placement under complete EUS control, without the use of either fluoroscopic or endoscopic views.
Material and methods Data on all consecutive patients who underwent EUS-guided drainage using the new ICSRT between June 2014 and April 2016 were retrospectively retrieved from two institution databases. All EUS procedures were performed by experienced endoscopists with the patient under conscious or deep sedation. The total procedure and stent deployment time, and adverse events related to stent positioning with the ICSRT were evaluated.
Results One hundred consecutive patients (51 women; mean age ± SD, 66 ± 15.2 years, range 34 – 95) underwent EUS-guided transluminal drainage with the Hot AXIOS™ device using the new ICSRT. The procedure was technically successful in all but one patient (1 %). The mean total procedural time was 21.9 minutes (range 7 – 50), while the mean time for stent placement was 3.2 minutes (range 1 – 15). No major adverse events occurred.
Discussion The ICSRT has been used to deploy the newly developed lumen-apposing FCSEMS under complete EUS guidance without fluoroscopic and/or endoscopic assistance. The technique appears to be safe and highly effective and should be learned by all interventional endosonographers in order to be able to perform drainage in all clinical scenarios.
Application of metabolomics to postharvest science of fresh crops.
Authors: Benkeblia N. 
Published: January 2017

Abstract
With more than 400 000 plant and 1 000 000 estimated metabolites, metabolomics is a promising tool that revealed its efficiency to study the complete set of small naturally present or stresses-elicited metabolites. In its recent progress, metabolomics led to a comprehensive and global analysis of metabolites and metabolic pathways in living tissues. Therefore, this approach is being further used to study the different postharvest stages of fresh crops, and building novel sets of data on the metabolic transition from immature, ripe and senescent fruit, as well as the effects of the different stresses affecting the fresh crop tissues during the handling, minimal processing and storage. Changes in primary and secondary pathways of sugars, organic acids, and, phenolic compounds, ethylene synthesis and fruit texture associated with physiological diseases, disorders and postharvest treatments for preservation and shelf-life extension are helping to track the specific related metabolites. In addition, broader use of metabolomics will speed the discovery of novel gene functions in primary and secondary metabolism and will provide comprehensive data sets necessary to model metabolic networks related to postharvest physiology and biochemistry of fresh crops. The data collected are crucial in setting the appropriate postharvest conditions by diverting the metabolism towards the desired pathways, or slowing down the undesired pathways, leading to efficient and affordable methods to reduce losses and extend the shelf-life of fresh crops. In this review, we aim to give a comprehensive view on the recent advances and applications of metabolomics to postharvest science in order to understand crop deterioration, and therefore, developing or improving existing techniques to extend shelf-life and shelf-life.
Analysis of water sorption isotherms of amorphous food materials by solution thermodynamics with relevance to glass transition: evaluation of plasticizing effect of water by the thermodynamic parameters
Authors: Shimazaki Eriko , Tashiro Akiko , Kumagai Hitomi , Kumagai Hitoshi 
Published: January 2017

Abstract
Relation between the thermodynamic parameters obtained from water sorption isotherms and the degree of reduction in the glass transition temperature (Tg), accompanied by water sorption, was quantitatively studied. Two well-known glassy food materials namely, wheat gluten and maltodextrin were used as samples. The difference between the chemical potential of water in a solution and that of pure water (), the difference between the chemical potential of solid in a solution and that of a pure solid (), and the change in the integral Gibbs free energy () were obtained by analyzing the water sorption isotherms using solution thermodynamics. The parameter correlated well with ΔTg (≡Tg − Tg0; where Tg0 is the glass transition temperature of dry material), which had been taken to be an index of plasticizing effect. This indicates that plasticizing effect of water on foods can be evaluated through the parameter .
Final report on the key comparison, CCM.M.P-K15.1 in the pressure range from 1.0 × 10-4 Pa to 1.0 Pa
Authors: Wuethrich Christian , Hongyan Yu 
Published: January 2017

At the CCM WG-LP meeting in Berlin in April 2011 the National Institute of Metrology of the people's republic of China asked for an opportunity to be linked to the CCM.M.P-K15 comparison which just ended. METAS, which had been active as pilot for the CCM.M.P-K15, agreed to make a link with NIM. The NIM introduced a new static expansion system in his laboratory.
Two spinning rotor gauges and a control electronic are used as transfer standard. The circulation of the transfer standard was made in spring 2012. The drift of the accommodation coefficient of the two SRG was measured by the pilot before and after the comparison. The stability of the transfer standards was excellent and the equivalence between METAS and NIM has been demonstrated.
A link to the CCM.M.P­K15 has been established using the results from METAS. It has been possible to achieve a link with a small uncertainty due to the strong correlation of the measurements of METAS in the two comparisons.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
MAPPI-DAT: data management and analysis for protein–protein interaction data from the high-throughput MAPPIT cell microarray platform
Authors: Gupta Surya , De Puysseleyr Veronic , Van der Heyden José , Maddelein Davy , Lemmens Irma , Lievens Sam , Degroeve Sven , Tavernier Jan , Martens Lennart 
Published: January 2017

Abstract

Summary
Protein-protein interaction (PPI) studies have dramatically expanded our knowledge about cellular behaviour and development in different conditions. A multitude of high-throughput PPI techniques have been developed to achieve proteome-scale coverage for PPI studies, including the microarray based Mammalian Protein-Protein Interaction Trap (MAPPIT) system. Because such high-throughput techniques typically report thousands of interactions, managing and analysing the large amounts of acquired data is a challenge. We have therefore built the MAPPIT cell microArray Protein Protein Interaction-Data management & Analysis Tool (MAPPI-DAT) as an automated data management and analysis tool for MAPPIT cell microarray experiments. MAPPI-DAT stores the experimental data and metadata in a systematic and structured way, automates data analysis and interpretation, and enables the meta-analysis of MAPPIT cell microarray data across all stored experiments.

Availability and Implementation
MAPPI-DAT is developed in Python, using R for data analysis and MySQL as data management system. MAPPI-DAT is cross-platform and can be ran on Microsoft Windows, Linux and OS X/macOS. The source code and a Microsoft Windows executable are freely available under the permissive Apache2 open source license at https://github.com/compomics/MAPPI-DAT.

Supplementary information
Supplementary data are available at Bioinformatics online.