bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cultural integration path for cross-border mergers and acquisitions from the perspective of acculturation
Authors: Cui Miao , Dong Crystal , Liu Yuekun , Wang Shujuan 
Published: August 2016

PurposeAn increasing number of Chinese enterprises are involved in cross-border mergers and acquisitions (M&As). However, few Chinese enterprises have achieved successful integration, which plays a critical role in enhancing performance. The important field of cultural integration is currently facing major challenges. To identify the reasons for these challenges, studies have analyzed why cultural integration succeeds or fails and have suggested that cultural differences between acquiring and acquired enterprises are the primary obstacles to cultural integration. However, it is unclear how success can be achieved. The paper aims to focus on cultural integration from the perspective of acculturation to describe the penetration of cultural elements in M&As.Design/methodology/approachIn adopting acculturation as our theoretical lens, the authors use the case study method to answer the following research question: “how can the cultural integration of Chinese enterprises be successfully achieved?” Two typical cases are examined: Lenovo’s cultural integration with IBM’s personal computer (PC) division and Haier’s cultural integration with Sanyo home appliance. First, using the exploratory case study method, the Lenovo–IBM PC division case is analyzed. The characteristics and relationships between cultural environments, employee adoption methods and acculturation patterns are summarized to reveal a cultural integration path. Second, the Haier–Sanyo home appliance case is analyzed using the confirmative case study method to test the findings of the Lenovo–IBM PC division case.FindingsThe results indicate that it is critical to achieve a dynamic fit between cultural environments, employee adoption methods and acculturation patterns during each stage of cultural integration (exploration, experimentation, reinforcement and fixing). The three constructs of these stages reflect the following evolutionary paths: “isolate-introduce-learning-chance taking”, “detecting-icebreaking-interacting-remodeling” and “specialized sections-senior managers-managers-employees”.Originality/valueThese findings contribute to the development of cultural integration and acculturation theories and serve as a reference for Chinese enterprises wishing to implement cultural integration strategies.
Vonoprazanversusconventional proton pump inhibitor‐based triple therapy as first‐line treatment againstHelicobacter pylori: A multicenter retrospective study in clinical practice
Authors: Shichijo Satoki , Hirata Yoshihiro , Niikura Ryota , Hayakawa Yoku , Yamada Atsuo , Mochizuki Satoshi , Matsuo Keigo , Isomura Yoshihiro , Seto Motoko , Suzuki Nobumi , Suzuki Hirobumi , Yamamoto Shinzo , Sugimoto Takafumi , Omae Tomoya , Okamoto Makoto , Watabe Hirotsugu , Togo Goichi , Takano Noriyuki , Fukui Keisuke , Ito Yuri , Koike Kazuhiko 
Published: August 2016

AbstractObjectiveVonoprazan is a potassium‐competitive acid blocker, a new type of acid‐suppressing drug, and has recently become available for peptic ulcers, gastroesophageal reflux disease, andHelicobacter pylori(H. pylori) eradication. Its efficacy forH.pylorieradication has been reported. However, the evidence for its efficacy and feasibility remains limited. We aimed to compare the feasibility, effectiveness and safety of vonoprazan‐based triple therapy with conventional proton pump inhibitor (PPI)‐based triple therapy in multicenter clinical practice.MethodsWe performed a multicenter retrospective study on patients receiving first‐lineH.pylorieradication therapy between March 2013 and November 2015 with either vonoprazan‐based triple therapy or conventional PPI‐based triple therapy.ResultsA total of 2715 patients aged 63.0 ± 12.1 years (1412 [52.0%] males) were analyzed. Eradication rates were 87.2% (368/422) for vonoprazan‐based therapy and 72.4% (1661/2293) for conventional PPI‐based therapy (P < 0.01). Among the former group, there were 10 cases of diarrhea, six of nausea/vomiting, and five of rash, but the rates of these adverse events were similar to those in the conventional PPI group.ConclusionVonoprazan‐based triple therapy is feasible, and has a higher rate forH. pylorieradication than conventional PPI as a first‐line regimen.
Multicenter Trial of Rivaroxaban for Early Discharge of Pulmonary Embolism From the Emergency Department (MERCURY PE): Rationale and Design
Authors: Singer Adam J. , Xiang Jim , Kabrhel Christopher , Merli Gino J. , Pollack Charles , Tapson Victor F. , Wildgoose Peter , Peacock W. Frank 
Published: August 2016

AbstractObjectivesTraditionally, patients with pulmonary embolism (PE) are admitted from the emergency department and treated with low‐molecular‐weight heparin followed by warfarin. Several studies now demonstrate that it is possible to identify low‐risk PE patients that can safely be treated as outpatients. The advent of the direct‐acting oral anticoagulants such as rivaroxaban has made it easier than ever to manage patients outside of the hospital. This article describes the design of a randomized controlled trial aimed at testing the hypothesis that low‐risk PE patients can be safely and effectively managed at home using rivaroxaban, resulting in fewer days of hospitalization than standard‐of‐care treatment.MethodsWe have initiated a multicenter, open‐label, randomized clinical trial in which low‐risk adult PE patients (identified by the Hestia criteria) are randomized to outpatient management with oral rivaroxaban 15 mg twice daily for 21 days followed by 20 mg once daily for 90 days versus standard care, determined by the treating physician and based on local practices. The primary clinical endpoint will be the total number of inpatient hospital days (including the index admission) for venous thromboembolic or bleeding‐related events during the first 30 days after randomization. A total of 150 subjects per group will provide 82% power to detect a difference of 1 day or greater in the primary outcome.ResultsPatient enrollment is ongoing at present in 45 of 60 planned sites. No interim analysis is planned and the study is being monitored by a data safety management board.ConclusionsThe MERCURY PE study is designed to test the hypothesis that outpatient management of low‐risk PE patients with rivaroxaban reduces the number of hospitalization days from venous thromboembolism and bleeding compared with standard care. This article describes the rationale and methodology for this study.
Hospital Admissions Before an Alcohol‐Related Death Among Middle‐Aged Employed Men and Women: A Cohort Study Using Routine Data
Authors: Paljärvi Tapio , Martikainen Pekka , Vahtera Jussi , Leinonen Taina , Mäkelä Pia 
Published: August 2016

BackgroundDue to lack of appropriate longitudinal data, relatively little is known about how and when persons who ultimately die due to alcohol‐related causes interact with hospitals during the years before death. Using routinely collected nationwide data, we aimed to establish the timing and causes of all hospitalizations during a 10‐year period before an alcohol‐related death.MethodsWe traced back the timing and causes of all hospitalizations occurring during a 10‐year period before death among men and women (n = 2,981) who were aged 35 and in employment at study entry, and who died from alcohol‐related causes at ages 45 to 54 in 1997 to 2007. The study data consisted of 80% of all persons living in Finland who died during the study period. Those who died at ages 45 to 54 without alcohol involvement were used as a reference group.ResultsPersons who ultimately died from alcohol‐related causes had on average 7 (mean 7.4, SD 9.9) hospital admissions, and they spent on average 56 days (mean 56.2, SD 105.1) in hospital during the study period. By the fifth year before death (from the year −10 to year −5), about three‐fifths of these persons had been hospitalized due to any cause at least once, but less than one‐third had a hospital admission with an alcohol‐related diagnosis. Those who died without alcohol involvement had an average 9 hospital admissions (mean 9.3, SD 11.2), and they spent on average 81 days (mean 81.2, SD 163.9) in hospital during the study period.ConclusionsThe majority of employed middle‐aged persons who ultimately died due to alcohol‐related causes interacted with hospitals frequently and already several years before death. Additional research is warranted to evaluate whether enhanced patient management at hospitals targeted to this population could potentially reduce alcohol‐related harms.
Making the hard work of recovery more attractive for those with substance use disorders
Authors: McKay James R. 
Published: August 2016

AbstractBackgroundResearch has led to improvements in the effectiveness of interventions for substance use disorders (SUD), but for the most part progress has been modest, particularly with regard to longer‐term outcomes. Moreover, most individuals with SUD do not seek out treatment.Argument/analysisThis paper presents two recommendations on how to improve treatment engagement and long‐term outcomes for those with SUD. First, treatments should go beyond a focus on reducing or eliminating substance use to target greater access to and more time spent in experiences that will be enjoyable or otherwise rewarding to clients. Secondly, there must be sufficient incentives in the environment to justify the effort needed to sustain long‐term abstinence for individuals who often have limited access to such incentives.ConclusionsTo increase rates of long‐term recovery from substance misuse, treatments should link clients to reinforcers that will make continued abstinence more appealing. This work needs to extend beyond interventions focused on the individual or family to include the local community and national policy in an effort to incentivize longer‐term recoveries more strongly.
Anterior iris‐claw intraocular lens implantation for the management of nontraumatic ectopia lentis: long‐term outcomes in a paediatric cohort
Authors: Català‐Mora Jaume , Cuadras Daniel , Díaz‐Cascajosa Jesús , Castany‐Aregall Marta , Prat‐Bartomeu Joan , García‐Arumí José 
Published: August 2016

AbstractPurposeTo report the feasibility and long‐term safety of lensectomy and iris‐claw intraocular lens (IOL) implantation to treat children with severe ectopia lentis in a paediatric tertiary hospital.MethodsProspective cohort study of 21 eyes from 12 patients with severe ectopia lentis and visual acuity <20/63. All eyes underwent 23‐gauge pars plana vitrectomy, lensectomy, iridectomy and Artisan IOL implantation in the anterior chamber with iris‐claw enclavation via pars plana. Mean age at surgery was 8.0 ± 5.3 yo (range 3–17 years). A full ophthalmologic examination including best‐corrected visual acuity (BCVA), biomicroscopy, intraocular pressure (IOP) measurement, fundus evaluation and central endothelial cell count (cECC) was performed pretreatment, at 3 months' postsurgery, and every 6 months thereafter. Ultrasound biomicroscopy (UBM) was performed 12 months after surgery.ResultsMean follow‐up was 39.3 ± 13.0 months. Best‐corrected visual acuity (BCVA) (mean ± SD) improved from 0.91 ± 0.29 logMar preoperatively to 0.18 ± 0.23 logMar at final follow‐up (p < 0.0001). Mean distance from the endothelium to the anterior IOL surface after surgery was 3.11 ± 0.61 mm. Postsurgically, cECC loss was 5.04% ± 9.58% with an annual cECC loss rate of 3.16% ± 4.46%. One patient developed IOL dislocation and retinal detachment after severe ocular contusion requiring vitrectomy, IOL refixation and gas tamponade. Another patient developed cystoid macular oedema, managed with intravitreal dexamethasone.ConclusionThis technique is both feasible and effective to manage severe ectopia lentis in children. Lifetime ophthalmic follow‐up including cECC measurement, IOL position monitoring and fundus examination is mandatory in these patients.
Changes in biomarkers during a six‐month oral immunotherapy intervention for cow's milk allergy
Authors: Salmivesi Susanna , Paassilta Marita , Huhtala Heini , Nieminen Riina , Moilanen Eeva , Korppi Matti 
Published: August 2016

AbstractAimOral immunotherapy (OIT) is a promising but still experimental method to treat children with cow's milk (CM) allergy (CMA). We evaluated changes in allergic, immunological and inflammatory parameters, which happened during the six‐month OIT for CMA.MethodsWe treated 28 school‐aged children with CMA using OIT with a double‐blind placebo‐controlled design. After the controlled study finished, the placebo group was treated with the same but open‐label OIT protocol. Sixteen immune variables were tested before and after the six‐month OIT.ResultsBefore OIT, the median serum CM‐specific immunoglobulin (Ig) E was 18.0kIU/L in the intervention group and 9.4kIU/L in the placebo group (p = 0.46). At six months, interleukin (IL)‐6 and IL‐10 were significantly higher in the intervention group. When the changes during the blinded and open OIT were analysed together for both groups, blood eosinophils and serum total IgE decreased and milk‐specific IgG and IgG4, serum IL‐4 and IL‐6, and serum leptin and resistin increased significantly.ConclusionPreliminary evidence was found that markers of allergy such as blood eosinophils and serum IgE decreased and milk‐specific IgG and IgG4 increased during OIT. Adipokines, leptin and resistin, which functionally are cytokines linked to Th1‐type response, increased during OIT.
Down's syndrome is a risk factor for severe lower respiratory tract infection due to respiratory syncytial virus
Authors: Galleguillos Constanza , Galleguillos Bárbara , Larios Guillermo , Menchaca Gonzalo , Bont Louis , Castro‐Rodriguez Jose A. 
Published: August 2016

AbstractAimPrevious studies have suggested that Down's syndrome is an independent risk factor for severe respiratory infection due to respiratory syncytial virus (RSV). We compared the clinical characteristics of children with and without Down's syndrome hospitalised due to RSV.MethodsThis retrospective cohort study compared data from hospitalisations due to RSV lower respiratory tract infections (LRTI) in children under 14 years of age with (n = 58) and without (n = 58) Down's syndrome.ResultsThe Down's group had longer hospital stays than the controls of six versus four days (p < 0.0001), even after adjusting for age, weeks of gestation at birth, presence of asthma, bronchopulmonary dysplasia, haemodynamically significant and nonsignificant congenital heart disease. This difference increased when only children under one year of age were analysed to 11 versus five days (p < 0.0001). Children with Down's syndrome were more likely to be admitted to intensive care unit (43.1% versus 22.4%, p = 0.017), need noninvasive mechanical ventilation (36.2% versus 13.7%, p = 0.005) and be prescribed antibiotics and steroids.ConclusionChildren with Down's syndrome hospitalised due to RSV LRTI had longer hospital stays and worse clinical courses than controls, highlighting the need for RSV prophylaxis for children with Down's syndrome, especially under one year of age.
Upregulations of CRH and CRHR1 in the Epileptogenic Tissues of Patients with Intractable Infantile Spasms
Authors: Yang Xiao‐Lin , Chen Bing , Zhang Xiao‐Qing , Chen Xin , Yang Mei‐Hua , Zhang Wei , Chen Huan‐Ran , Zang Zhen‐Le , Li Wei , Yang Hui , Liu Shi‐Yong 
Published: August 2016

SummaryAimInfantile spasms (IS) are an age‐specific epileptic syndrome with specific clinical symptom and electroencephalogram (EEG) features, lacking treatment options, and a poor prognosis. Excessive endogenous corticotropin‐releasing hormone (CRH) in infant brain might result in IS. However, the data from human IS are limited. In our study, we investigated the expressions of CRH and its receptor type 1 (CRHR1) in surgical tissues from patients with IS and autopsy controls.MethodsSpecimens surgically removed from 17 patients with IS, and six autopsy controls were included in the study. Real‐time PCR, Western blotting, and immunostaining were used to detect the expressions of mRNA, protein expression, and distribution. The correlation between variates was analyzed by Spearman rank correlation.ResultsThe expressions of CRH and CRHR1 were significantly upregulated in the epileptogenic tissues of IS patients compared with the control group. CRH was distributed mainly in neurons, while CRHR1 was distributed in neurons, astrocytes, and microglia. The expression levels of CRH and CRHR1 were positively correlated with the frequency of epileptic spasms. Moreover, the expression of protein kinase C (PKC), which was an important downstream factor of CRHR1, was significantly upregulated in the epileptogenic tissues of patients with IS and was positively correlated with the CRHR1 expression levels and the frequency of epileptic spasms.ConclusionThese results suggest that the CRH signal transduction pathway might participate in the epileptogenesis of IS, supporting the hypothesis that CRH is related to the pathogenesis of IS.
Cognitive and outcome measures seem suboptimal in children with cochlear implants – a cross‐sectional study
Authors: Udholm N. , Aaberg K. , Bloch C. , Sandahl M. , Ovesen T. 
Published: August 2016

ObjectiveThis study investigates whether cognition as a single variable significantly influences the hearing and speech outcomes of children with cochlear implants (CIs). More specifically, it identifies various types of cognitive disorders among children with CI, comparing these children's cognitive abilities to the outcomes of CI in terms of hearing and speech performance.Study designCross‐sectional cognitive testing of children with CIs.SettingWest Danish CI Centre, Aarhus University Hospital, Denmark.Materials and methodsFifty‐eight CI children underwent postoperative cognitive evaluation. Cognitive tests included Bayley Scales of Infant Development (Bayley‐III), Snijders‐Oomen Nonverbal Intelligence Test Revised (SON‐R) and Wechsler Intelligence Scale for Children, Fourth Edition (WISC‐IV), depending on the age of the child. Outcome measures of hearing and speech capacity after CI consisted of Categories of Auditory Performance (CAP), Speech Intelligibility Rating (SIR) and Peabody Picture Vocabulary Test‐4 (PPVT‐4).ResultsOnly PPVT‐4 correlated significantly with cognition scores. Over time, the value of CAP and SIR seems limited by a pronounced ceiling effect.ConclusionThe most widely used outcome tests after CI, that is CAP and SIR, may not reflect cognitive disabilities sufficiently due to pronounced ceiling effects. International guidelines suggesting a panel of robust age‐matched tests are warranted to optimise rehabilitation programmes as well as the counselling of parents.
Quality indicators of integrated care for patients with head and neck cancer
Authors: van Overveld L.F.J. , Braspenning J.C.C. , Hermens R.P.M.G. 
Published: August 2016

ObjectivesOncological care is very complex, and delivery of integrated care with optimal alignment and collaboration of several disciplines is crucial. To monitor and effectively improve high‐quality integrated oncological care, a dashboard of valid and reliable quality indicators (QIs) is indispensable. The aim was to develop multidisciplinary QIs to measure quality of integrated oncological care, specifically for head and neck cancer (HNC) patients.DesignThe RAND‐modified Delphi method was used to decide on the outcome, process and structure QIs form three different perspectives. In addition, case‐mix factors were determined.SettingIntegrated HNC in the Netherlands.ParticipantsHead and neck cancer patients, chairmen of both patient organisations and medical specialists and allied health professionals involved in HNC care in the Netherlands.Main outcome measuresOutcome, process and structure indicators.ResultsOutcome indicators were assigned to healthcare status, tumour recurrence, complications, quality of life and patient experiences. The process indicators focused on the (allied health) care aspects during the diagnostic, treatment and follow‐up phases, for example regarding waiting times, multidisciplinary team meetings and screening for the need of allied health care.ConclusionsThis is the first set of multidisciplinary QIs for HNC care, to assess quality of integrated care agreed by patients and professionals. This set can be used to build other oncological quality dashboards for integrated care.
Reducing falls in Parkinson's disease: interactions between donepezil and the 5‐HT6 receptor antagonist idalopirdine on falls in a rat model of impaired cognitive control of complex movements
Authors: Kucinski Aaron , de Jong Inge E. M. , Sarter Martin 
Published: August 2016

AbstractFalls are a leading cause of death in the elderly and, in a majority of patients with Parkinson's disease (PD), the leading levodopa‐insensitive cause of hospitalization and long‐term care. Falling in PD has been attributed to degeneration of forebrain cholinergic neurons that, in interaction with striatal dopamine losses, impairs the cognitive control of balance, gait, and movement. We previously established an animal model of these dual cholinergic–dopaminergic losses (“DL rats”) and a behavioral test system (Michigan Complex Motor Control Task, MCMCT) to measure falls associated with traversing dynamic surfaces and distractors. Because the combined treatment of the acetylcholinesterase inhibitor donepezil and the 5‐HT6 receptor antagonist idalopirdine (Lu AE58054) was reported to exhibit synergistic pro‐cholinergic activity in rats and improved cognition in patients with moderate Alzheimer's disease, here we assessed the effects of this treatment on MCMCT performance and attention in DL rats. Compared with the vehicle‐treated group, the combined treatment greatly reduced (Cohen's d = 0.96) falls in DL rats when traversing dynamic surfaces and when exposed to a passive distractor. However, falls associated with a dual task distractor and sustained attentional performance did not benefit from this treatment. Analyses of the behavior in fall‐prone moments suggested that this treatment improved the efficacy and speed of re‐instating forward movement after relatively short stoppages. This treatment may reduce fall propensity in PD patients via maintaining planned movement sequences in working memory and improving the vigor of executing such movements following brief periods of freezing of gait.