bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semaphorin 7A Promotes Chemokine-Driven Dendritic Cell Migration
Authors: van Rijn Anoek , Paulis Leonie , te Riet Joost , Vasaturo Angela , Reinieren-Beeren Inge , van der Schaaf Alie , Kuipers Arthur J. , Schulte Luuk P. , Jongbloets Bart C. , Pasterkamp R. Jeroen , Figdor Carl G. , van Spriel Annemiek B. , Buschow Sonja I. 
Published: November 2015

Abstract
Dendritic cell (DC) migration is essential for efficient host defense against pathogens and cancer, as well as for the efficacy of DC-based immunotherapies. However, the molecules that induce the migratory phenotype of DCs are poorly defined. Based on a large-scale proteome analysis of maturing DCs, we identified the GPI-anchored protein semaphorin 7A (Sema7A) as being highly expressed on activated primary myeloid and plasmacytoid DCs in human and mouse. We demonstrate that Sema7A deficiency results in impaired chemokine CCL21-driven DC migration in vivo. Impaired formation of actin-based protrusions, resulting in slower three-dimensional migration, was identified as the mechanism underlying the DC migration defect. Furthermore, we show, by atomic force microscopy, that Sema7A decreases adhesion strength to extracellular matrix while increasing the connectivity of adhesion receptors to the actin cytoskeleton. This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive DC migration in response to CCL21.
Selective CD28 Antagonist Blunts Memory Immune Responses and Promotes Long-Term Control of Skin Inflammation in Nonhuman Primates
Authors: Poirier Nicolas , Chevalier Melanie , Mary Caroline , Hervouet Jeremy , Minault David , Baker Paul , Ville Simon , Le Bas-Bernardet Stephanie , Dilek Nahzli , Belarif Lyssia , Cassagnau Elisabeth , Scobie Linda , Blancho Gilles , Vanhove Bernard 
Published: November 2015

Abstract
Novel therapies that specifically target activation and expansion of pathogenic immune cell subsets responsible for autoimmune attacks are needed to confer long-term remission. Pathogenic cells in autoimmunity include memory T lymphocytes that are long-lived and present rapid recall effector functions with reduced activation requirements. Whereas the CD28 costimulation pathway predominantly controls priming of naive T cells and hence generation of adaptive memory cells, the roles of CD28 costimulation on established memory T lymphocytes and the recall of memory responses remain controversial. In contrast to CD80/86 antagonists (CTLA4-Ig), selective CD28 antagonists blunt T cell costimulation while sparing CTLA-4 and PD-L1–dependent coinhibitory signals. Using a new selective CD28 antagonist, we showed that Ag-specific reactivation of human memory T lymphocytes was prevented. Selective CD28 blockade controlled both cellular and humoral memory recall in nonhuman primates and induced long-term Ag-specific unresponsiveness in a memory T cell–mediated inflammatory skin model. No modification of memory T lymphocytes subsets or numbers was observed in the periphery, and importantly no significant reactivation of quiescent viruses was noticed. These findings indicate that pathogenic memory T cell responses are controlled by both CD28 and CTLA-4/PD-L1 cosignals in vivo and that selectively targeting CD28 would help to promote remission of autoimmune diseases and control chronic inflammation.
Eigenvarieties for Cuspforms Over PEL
Type Shimura Varieties With Dense Ordinary Locus
Authors: Brasca Riccardo 
Published: November 2015

AbstractLet p > 2 be a prime and let X be a compactified PEL Shimura variety of type (A) or (C) such that p is an unramified prime for the PEL datum and such that the ordinary locus is dense in the reduction of X. Using the geometric approach of Andreatta, Iovita, Pilloni, and Stevens, we define the notion of families of overconvergent locally analytic p-adic modular forms of Iwahoric level for X. We show that the systemof eigenvalues of any finite slope cuspidal eigenformof Iwahoric level can be deformed to a family of systems of eigenvalues living over an open subset of the weight
space. To prove these results, we actually construct eigenvarieties of the expected dimension that parameterize finite slope systems of eigenvalues appearing in the space of families of cuspidal forms.
CHLOROHYDRINATION OF NR LATEX BY USING SODIUM HYPOCHLORITE FOR FUEL-RESISTANT MATERIALS
Authors: Chanroj T. , Paoprasert P. 
Published: November 2015

ABSTRACT
NR is hydrophobic and cannot be used to store, transfer, or make contact with hydrocarbon compounds. We report a simple method to increase the hydrophilicity of NR: a chlorohydrination reaction of NR latex by using sodium hypochlorite is described. It was found that only chlorohydrinated NR was obtained and side products were unnoticeable. The effects of sodium hypochlorite concentration, hydrochloric acid concentration, surfactant concentration, and reaction time on chlorohydrin content in NR were investigated. The swelling resistance of chlorohydrinated NR with 11% chlorohydrin content in diesel and gasohol fuels was improved nearly 3-fold and 4-fold, respectively, compared to that of the unmodified NR. The thermal and mechanical properties of the chlorohydrinated NR were characterized and found to be similar to those of pristine NR, indicating that the chlorohydrinated NR can be an excellent substitute for NR. This method has merits such as low cost of raw materials, easier and greener production processes than traditional methods, and scaling-up possibilities for the fabrication of chlorohydrinated NR for a variety of applications.
Strong insertion of a $\gamma-$ continuous function
Authors: Mirmiran Majid , Naderi Binesh 
Published: November 2015

Necessary and sufficient conditions in terms of lower cut sets are given for the strong insertion of a $\gamma-$continuous function between two comparable real-valued functions.In this paper, is given a sufficient condition for the weak $\gamma-$insertion property. Also for a space with the weak $\gamma-$insertion property, we give necessary and sufficient conditions for the space to have the strong $\gamma-$insertion property. Several insertion theorems are obtained as corollaries of these results.
Factors Influencing Energy Intensity in Four Chinese Industries
Authors: Fisher-Vanden Karen , Hu Yong , Jefferson Gary , Rock Michael , Toman Michael 
Published: November 2015

In this paper, we investigate the determinants of decline in energy intensity in four Chinese industries—pulp and paper, cement, iron and steel, and aluminum. This paper attempts to answer the following key question: For the purpose of promoting energy efficiency, do prices, technology, enterprise restructuring and other policy-related instruments affect various sectors uniformly so as to justify uniform industrial energy conservation policies, or do different industries respond significantly differently so as to require policies that are tailored to each sector separately? In this paper, we examine this question using data for China’s most energy-intensive large and medium-size enterprises over the period 1999-2004. Our results suggest that in all four industries rising energy costs are a significant contributor to the decline in energy intensity over our period of study. China’s industrial policies encouraging consolidations and scale economies also seem to have contributed to reductions in energy intensity in these four industries.
Het renvoi-artikel van de Erfrechtverordening
Authors: Lokin P.A.M. 
Published: November 2015

Het renvoi-artikel van de erfrechtverordening
Ten einde beslissingsharmonie te bereiken tussen lidstaten en derde staten die betrokken zijn bij eenzelfde erfopvolging, wordt het Europese verwijzingsresultaat in bepaalde situaties afgestemd op het verwijzingsresultaat van deze derde staten. Deze afstemming wordt ook wel aangeduid als renvoi. In deze bijdrage wordt ingegaan op de toepassing van het renvoi-artikel van de Erfrechtverordening.
De Europese erfrechtverklaring en het huwelijksvermogensrecht
Authors: Maasland J.L.D.J. 
Published: November 2015

De Europese erfrechtverklaring en het huwelijksvermogensrecht
De Europese Erfrechtverordening is niet van toepassing op kwesties die verband houden met huwelijksvermogensrecht. De omvang en samenstelling van de nalatenschap van een gehuwde erflater wordt mede bepaald door het huwelijksvermogensregime. Tegen deze achtergrond dient in Bijlage III van de Europese erfrechtverklaring informatie over het huwelijksvermogensstelsel van de erflater te worden ingevuld. In deze bijdrage behandelt de auteur de vraag op basis van welk recht Bijlage III dient te worden ingevuld. Ook gaat hij in op de bewijskracht van Bijlage III van de erfrechtverklaring.
Ruimtelijk plannen met buisleidingen: verleden, heden en toekomst
Authors: Wind-Middel I.J. (Ingeborg) 
Published: November 2015

Ruimtelijk plannen met buisleidingen: verleden, heden en toekomst
In deze bijdrage wordt ingegaan op buisleidingen in het omgevingsrecht met een focus op ruimtelijke planning. Het betreft een overzichtsartikel en daarmee een handreiking voor degenen die zich willen oriënteren op de toepasselijke ruimtelijke kaders. Om het huidige beleid in perspectief te plaatsen, zal allereerst het belangrijkste ‘oude’ beleid voor buisleidingen in relatie tot ruimtelijke ordening worden besproken (‘verleden’). Vervolgens zal worden ingegaan op de thans geldende belangrijkste ruimtelijke wet- en regelgeving (‘heden’). Tot slot wordt het wetsvoorstel Omgevingswet kort besproken (‘toekomst’). Andere interessante aanpalende onderwerpen zoals gedogen (Belemmeringenwet Privaatrecht, BP), nadeelcompensatie, eigendom of de Telecommunicatiewet Publiekrecht komen in deze bijdrage niet of slechts zijdelings aan bod.
Op naar een algemene boetebevoegdheid in de Omgevingswet
Authors: Jansen O.J.D.M.L. (Oswald) 
Published: November 2015

Op naar een algemene boetebevoegdheid in de Omgevingswet
In deze bijdrage wordt het sanctiestelsel in het voorstel voor een Omgevingswet (zoals aangenomen door de Tweede Kamer) besproken aan de hand van een vergelijking met boetesystemen in andere wetten en het advies van de Afdeling advisering van de Raad van State.
De provinciale ladders voor duurzame verstedelijking
Authors: Gierveld H.A.J. (Henk) 
Published: November 2015

De provinciale ladders voor duurzame verstedelijking
In deze bijdrage worden de aanvullende eisen die in provinciale verordeningen worden gesteld aan stedelijke ontwikkeling besproken. Vervolgens worden de verschillen tussen de provinciale verordeningen geanalyseerd en getoetst aan de provinciale bevoegdheid om nadere regels te stellen.
Natura 2000 en Bouwen met de Natuur: een blik op de praktijkervaring in een zoektocht naar synergie tussen economie en ecologie
Authors: Vikolainen V. (Vera) , Heldeweg M. (Michiel) , Lulofs K. (Kris) , Bressers H. (Hans) 
Published: November 2015

Natura 2000 en Bouwen met de Natuur: een blik op de praktijkervaring in een zoektocht naar synergie tussen economie en ecologie
De toepassing van Europese natuurbeschermingsregels wordt bij veel infrastructurele projecten als juridische belemmering ervaren. In deze bijdrage geven de auteurs een positieve blik op de ervaringen in of nabij Natura 2000-gebieden in Noordwest-Europese estuaria en kustgebieden en stellen dat Natura 2000 niet per se een struikelblok hoeft te vormen, en dat het toepassen van innovatieve ontwerpmethoden als Bouwen met de Natuur het verschil kan maken voor de implementatie van Natura 2000 op projectniveau. Empirisch bewijs hiervoor is in veertien cases gezocht, waarbij drie verschillende onderzoeksontwerpen zijn gebruikt. Afgesloten wordt met een vooruitblik naar wat dit betekent voor de private partijen en overheden, voor de evaluatie van Natura 2000 in 2015 en voor Bouwen met de Natuur als innovatieve ontwerpmethode.
The Digital Dilemma
Authors: Clarke Mary 
Published: November 2015

AbstractThe long-term care of collected and created data is an ethical obligation in the fields of archaeology and cultural heritage management. With the growing application of digital methodologies in these fields and the complexity of the resulting data, this task has become complicated. Digital data preservation firms have emerged since this methodological shift, but their policies—championing the democratization of academic data—may conflict with the legal obligations dictated by the countries where data originate. Scholars thus face an inevitable choice between two obligations, one ethical and one legal. While the amount of digital data grows and the options for preservation remain fundamentally misaligned with research norms and project workflows, the digital dilemma places the integrity of data at risk of loss. This article addresses this dilemma by evaluating the existing data publication, archiving, and preservation repositories and considering how, as solutions to the digital dilemma, they can be integrated into multiple workflows. I also propose new directions for archaeological associations, suggesting that they should establish a means of evaluation and approval for third-party preservation firms managing the future of academic research prior to their inevitable ubiquity.
Integrating Older Survey Data into Modern Research Paradigms
Authors: Ullah Isaac I. T. 
Published: November 2015

AbstractThe data from older archaeological surveys are incredibly important resources, often containing our only information about sites that have been destroyed or that are now inaccessible. These surveys occurred before the advent of GPS technology, however, so their spatial accuracy is often uncertain. Many types of locational errors accumulate in such “legacy” datasets, so using them in modern GIS-based spatial analyses is frequently problematic. Many of the sources of error can be identified and quantified, however, and systematic and random errors (derived mainly from Cartesian, rounding, and human error) can largely be mitigated by scanning the original field maps, georectifying the maps to trusted imagery, and then digitizing sites directly. The remaining “mislocation” errors derive from difficulty identifying locations in the field. The original survey notes may contain clues about mislocation error, but it is impossible to mitigate these errors without re-recording site locations with more accurate survey instruments. Instead, I advocate the use of GIS-based models to estimate the influence of specific surveying practices on site location accuracy. These models can provide a standardized, quantifiable measure of mislocation error in a legacy dataset, which can help guide its use in modern GIS analyses that require accurate site locations.
Research Data Management at 9 Universities in Baden-Wuerttemberg, Germany. The Results from the Final Report of the bwFDM Communities Project
Authors: Pappenberger Karlheinz 
Published: November 2015

See video of the presentation.On 17th July 2015 the Ministry of Science, Research and the Arts for Baden-Wuerttemberg, Germany, invited national experts to the presentation of the final report of the ‘bwFDM communities’ project. This 18 month project was launched at the beginning of 2014 to evaluate the needs of services and the support that libraries and IT service centres should offer researchers in the area of research data management. Full-time key project staff had been established at all 9 universities in the state of Baden-Wuerttemberg to conduct semi-structured personal interviews of all research groups working with research data (in a broad sense including all areas of science, social science and humanities) and to document them in the form of user stories. 627 interviews have been conducted and more than 2,500 user stories could be extracted, showing the wide range of needs and wishes articulated by researchers. On this basis issues of importance and requirements had be identified, categorised in 18 different groups and finalised into an analysis of the status quo and recommendations for concrete action plans. The results cover the areas ‘general requirements and policy framework’, ‘data collection and data sharing’, ‘technical framework and virtual research environments’, ‘preservation’, ‘IT infrastructure and IT support’, ‘licencing’ and ‘Open Science’.The presentation will give an overview of the project results and will highlight the roles libraries and IT service centres are expected to play from the researcher´s point of view.As the final report to the Ministry contributes to a comprehensive research data management strategy for the State of Baden-Wuerttemberg, the presentation will also point out the status of the federal strategy in RDM.
User-driven scholarly communications - The Stockholm University Library example
Authors: Wennström Sofie 
Published: November 2015

See video of the presentation.Stockholm University Press (SUP) has implemented a working model for the development of their services where exchange of ideas and best practices between the press staff and the researchers is driving development. This is done through strategic partnerships nationally and internationally, as well as with the active researchers at the university. SUP aim to build a sustainable model for publication of peer-reviewed books and journals by optimising our involvement in these networks and by sharing knowledge and information openly. The success of scholarly communication relies on indexing and dissemination. The dissemination channels created need to be in place from the very beginning of the development of a new press. However, most indexes require that you already have content to show in order to add their quality stamp to the press. How do we deal with this catch 22?Stockholm University Press was founded in 2014, and published its first Open Access books in early 2015 with one academic journal is already up and running. Three more journals will be added to the list in 2016. SUP have implemented editorial practices for transparency and quality assessment, which are necessary in order to create the level of credibility needed to gain trust among dissemination channels. Building the press also include an intrinsic function to evaluate the work with the help of publication data in combination with so-called ‘allmetrics’. The data will then be reused to empower the author by providing tools for analysis of these numbers for the individual as well as the entire university. So, how do we create these incentives, and how do we make them count? How do we make the press and library activities worthwhile for the entire University?The last quarter of the development loop includes learning tools for researchers at the institution where we can share knowledge about scholarly communication in general, based on the publication metrics we can provide and the lessons learned with the press. This is a work in progress, and something we would like to share with the delegates. The new learning environment is intended to become intrinsic in the publishing process and can drive development of knowledge and technology based on user involvement and input.This presentation aim to further describe the case of Stockholm University Press, how we plan to move forward in the immediate future, and last but not least show plans for further developments of learning tools and services for researchers. The iterative development processes used are supported by the practices of open access, both to knowledge, data and research results.
Preceptor doctors' assessment of the clinical skills of chiropractic externs
Authors: Hynes Roger J.R. , Callender Alana K. , Hynes Rachelle A. , Gran Donald F. 
Published: November 2015

Objective: This study surveyed preceptor doctors' opinions of student competence before and after a chiropractic preceptorship.Methods: The qualitative and quantitative survey asked doctors about the competence of externs in various skills and asked opened-ended questions about the strengths and weaknesses of the externs. The survey was conducted using a common Web-based platform called SurveyMonkey.Results: A total of 125 doctors responded to the survey. The doctors tended to agree that they saw a positive change in the skills of the externs over time. Externs presented to the preceptors lacking in confidence and office management skills. The preceptors reported an increase from 2.7 to 3.9 on a 5.0 Likert scale in the students' confidence in adjusting skills during the preceptorship. The preceptor doctors were split on students' preparedness in chiropractic adjusting technique, reporting it as both the strongest and the weakest presenting skill.Conclusion: Preceptor doctors perceived that their student externs were academically qualified but were weaker in the clinical application of procedures. Results from this survey suggest that the preceptor program can improve the confidence levels and practice management knowledge of chiropractic externs.
Establishing force and speed training targets for lumbar spine high-velocity, low-amplitude chiropractic adjustments*
Authors: Owens Edward F. , Hosek Ronald S. , Sullivan Stephanie G.B. , Russell Brent S. , Mullin Linda E. , Dever Lydia L. 
Published: November 2015

Objective: We developed an adjusting bench with a force plate supporting the lumbar portion to measure loads transmitted during lumbar manual adjustment. It will be used to provide force-feedback to enhance student learning in technique labs. The study goal is to define the learning target loads and speeds, with instructors as expert models.
Methods: A total of 11 faculty members experienced in teaching Gonstead technique methods performed 81 simulated adjustments on a mannequin on the force plate. Adjustments were along 9 lumbopelvic “listings” at 3 load levels: light, normal, and heavy. We analyzed the thrusts to find preload, peak load, duration, and thrust rate.
Results: Analysis of 891 thrusts showed wide variations between doctors. Peak loads ranged from 100 to 1400 N. All doctors showed clear distinctions between peak load levels, but there was overlap between high and low loads. Thrust rates were more uniform across doctors, averaging 3 N/ms.
Conclusion: These faculty members delivered a range of thrusts, not unlike those seen in the literature for high velocity, low amplitude manipulation. We have established at least minimum force and speed targets for student performance, but more work must be done to create a normative adjustment to guide refinement of student learning.
Neural Operator Approximations for Boundary Stabilization of Cascaded Parabolic PDEs
Authors: Lv Kaijing , Wang Junmin , Cao Yuandong 
Published: September 2024

ABSTRACTThis article proposes a novel method to accelerate the boundary feedback control design of cascaded parabolic difference equations (PDEs) through DeepONet. The backstepping method has been widely used in boundary control problems of PDE systems, but solving the backstepping kernel function can be time‐consuming. To address this, a neural operator (NO) learning scheme is leveraged for accelerating the control design of cascaded parabolic PDEs. DeepONet, a class of deep neural networks designed for approximating nonlinear operators, has shown potential for approximating PDE backstepping designs in recent studies. Specifically, we focus on approximating gain kernel PDEs for two cascaded parabolic PDEs. We utilize neural operators to map only two kernel functions, while the other two are computed using the analytical solution, thus simplifying the training process. We establish the continuity and boundedness of the kernels, and demonstrate the existence of arbitrarily close DeepONet approximations to the kernel PDEs. Furthermore, we demonstrate that the DeepONet approximation gain kernels ensure stability when replacing the exact backstepping gain kernels. Notably, DeepONet operator exhibits computation speeds two orders of magnitude faster than PDE solvers for such gain functions, and their theoretically proven stabilizing capability is validated through simulations.