bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association among sickle cell trait, fitness, and cardiovascular risk factors in CARDIA
Authors: Liem Robert I. , Chan Cheeling , Vu Thanh-Huyen T. , Fornage Myriam , Thompson Alexis A. , Liu Kiang , Carnethon Mercedes R. 
Published: November 2016

Key Points
SCT status is not significantly associated with longitudinal changes in fitness among African Americans. SCT status is not an independent risk factor for hypertension, diabetes, or metabolic syndrome among African Americans.
Protein ligand-specific binding residue predictions by an ensemble classifier
Authors: Hu Xiuzhen , Wang Kai , Dong Qiwen 
Published: November 2016

Abstract
Background
Prediction of ligand binding sites is important to elucidate protein functions and is helpful for drug design. Although much progress has been made, many challenges still need to be addressed. Prediction methods need to be carefully developed to account for chemical and structural differences between ligands.

Results
In this study, we present ligand-specific methods to predict the binding sites of protein-ligand interactions. First, a sequence-based method is proposed that only extracts features from protein sequence information, including evolutionary conservation scores and predicted structure properties. An improved AdaBoost algorithm is applied to address the serious imbalance problem between the binding and non-binding residues. Then, a combined method is proposed that combines the current template-free method and four other well-established template-based methods. The above two methods predict the ligand binding sites along the sequences using a ligand-specific strategy that contains metal ions, acid radical ions, nucleotides and ferroheme. Testing on a well-established dataset showed that the proposed sequence-based method outperformed the profile-based method by 4–19% in terms of the Matthews correlation coefficient on different ligands. The combined method outperformed each of the individual methods, with an improvement in the average Matthews correlation coefficients of 5.55% over all ligands. The results also show that the ligand-specific methods significantly outperform the general-purpose methods, which confirms the necessity of developing elaborate ligand-specific methods for ligand binding site prediction.

Conclusions
Two efficient ligand-specific binding site predictors are presented. The standalone package is freely available for academic usage at http://dase.ecnu.edu.cn/qwdong/TargetCom/TargetCom_standalone.tar.gz or request upon the corresponding author.
Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response
Authors: Silva Richard C. , Sattlegger Evelyn , Castilho Beatriz A. 
Published: November 2016

ABSTRACT
Genetic and pharmacological interventions in yeast and mammalian cells have suggested a cross-talk between the actin cytoskeleton and protein synthesis. Regulation of the activity of the translation initiation factor 2 (eIF2) is a paramount mechanism for cells to rapidly adjust the rate of protein synthesis and to trigger reprogramming of gene expression in response to internal and external cues. Here, we show that disruption of F-actin in mammalian cells inhibits translation in a GCN2-dependent manner, correlating with increased levels of uncharged tRNA. GCN2 activation increased phosphorylation of its substrate eIF2α and the induction of the integrated stress response master regulator, ATF4. GCN2 activation by latrunculin-B is dependent on GCN1 and inhibited by IMPACT. Our data suggest that GCN2 occurs in two different complexes, GCN2–eEF1A and GCN2–GCN1. Depolymerization of F-actin shifts GCN2 to favor the complex with GCN1, concomitant with GCN1 being released from its binding to IMPACT, which is sequestered by G-actin. These events might further contribute to GCN2 activation. Our findings indicate that GCN2 is an important sensor of the state of the actin cytoskeleton.
MZT1 regulates microtubule nucleation by linking γTuRC assembly to adapter-mediated targeting and activation
Authors: Cota Rosa Ramírez , Teixidó-Travesa Neus , Ezquerra Artur , Eibes Susana , Lacasa Cristina , Roig Joan , Lüders Jens 
Published: November 2016

ABSTRACT
Regulation of the γ-tubulin ring complex (γTuRC) through targeting and activation restricts nucleation of microtubules to microtubule-organizing centers (MTOCs), aiding in the assembly of ordered microtubule arrays. However, the mechanistic basis of this important regulation remains poorly understood. Here, we show that, in human cells, γTuRC integrity, determined by the presence of γ-tubulin complex proteins (GCPs; also known as TUBGCPs) 2–6, is a prerequisite for interaction with the targeting factor NEDD1, impacting on essentially all γ-tubulin-dependent functions. Recognition of γTuRC integrity is mediated by MZT1, which binds not only to the GCP3 subunit as previously shown, but cooperatively also to other GCPs through a conserved hydrophobic motif present in the N-termini of GCP2, GCP3, GCP5 and GCP6. MZT1 knockdown causes severe cellular defects under conditions that leave γTuRC intact, suggesting that the essential function of MZT1 is not in γTuRC assembly. Instead, MZT1 specifically binds fully assembled γTuRC to enable interaction with NEDD1 for targeting, and with the CM1 domain of CDK5RAP2 for stimulating nucleation activity. Thus, MZT1 is a ‘priming factor’ for γTuRC that allows spatial regulation of nucleation.
The defensive response of the honeybee Apis mellifera
Authors: Nouvian Morgane , Reinhard Judith , Giurfa Martin 
Published: November 2016

ABSTRACT
Honeybees (Apis mellifera) are insects living in colonies with a complex social organization. Their nest contains food stores in the form of honey and pollen, as well as the brood, the queen and the bees themselves. These resources have to be defended against a wide range of predators and parasites, a task that is performed by specialized workers, called guard bees. Guards tune their response to both the nature of the threat and the environmental conditions, in order to achieve an efficient trade-off between defence and loss of foraging workforce. By releasing alarm pheromones, they are able to recruit other bees to help them handle large predators. These chemicals trigger both rapid and longer-term changes in the behaviour of nearby bees, thus priming them for defence. Here, we review our current understanding on how this sequence of events is performed and regulated depending on a variety of factors that are both extrinsic and intrinsic to the colony. We present our current knowledge on the neural bases of honeybee aggression and highlight research avenues for future studies in this area. We present a brief overview of the techniques used to study honeybee aggression, and discuss how these could be used to gain further insights into the mechanisms of this behaviour.
Assessing Fair Lending Risks Using Race/Ethnicity Proxies
Authors: Zhang Yan 
Published: November 2016

Fair lending analysis of nonmortgage credit products often involves proxying for race/ethnicity since such information is not required to be reported. Using mortgage data, this paper evaluates a series of proxy approaches (geo, surname, geo-surname, and Bayesian Improved Surname Geocoding (BISG)) as compared with the race/ethnicity reported under the Home Mortgage Disclosure Act (HMDA). The BISG proxy predicts the reported race/ethnicity the best as judged by prediction bias, correlation coefficient, and discriminatory power. In assessing fair lending risks where classification of race/ethnicity is called for, we propose the BISG maximum classification, which produces a more accurate estimation of mortgage pricing disparities than the current practices. The above conclusions withhold various robustness tests. Additional analysis is performed to assess the proxies on nonmortgage credits by leveraging consumer credit bureau data.This paper was accepted by Amit Seru, finance.
Development and cost–benefit analysis of a nurse-led paracentesis and infusion service
Authors: Menon Shyam , Thompson La-Sandra , Tan Maria , Chahal Sundeep , Black Doreen , Hill Keely Anne , Gritton Dean , Hathaway Charlotte , Perry Ian 
Published: November 2016

The rising incidence of chronic liver disease has resulted in many patients needing recurrent paracentesis for abdominal ascites, which requires hospital admission. A novel nurse-led and delivered day-case paracentesis and intravenous infusion service was developed, and a cost-benefit analysis was undertaken to examine the impact of this service. Data for patients admitted for ascitic paracentesis and intravenous infusions between April and January 2016 were collected, and procedure-related costs and income were calculated. Savings delivered by the service were calculated by determining the cost of bed-days saved by the day-case service. A qualitative analysis of the efficacy of the service was conducted by a patient feedback survey. Over the 10-month period, 559 patients were treated by the day-case service—144 ascitic paracenteses (26%), 87 iron infusions (16%), 307 infliximab infusions (55%) and 21 magnesium infusions (3%). Net income over 10-months was £256 876, with an expenditure of £128 570, yielding a profit of £128 306. Cost-modelling exercises indicated that this would yield an additional cost saving of £153 216 due to inpatient bed-days saved, yielding a total financial benefit of £281 522 (over 10-months). A day-case, nurse-led gastroenterology service provides an innovative, profitable and cost-efficient model of service delivery.
Title: Development and Refinement of a Learning Health Systems Training
Program
Authors: Wysham Nicholas G. , Howie Lynn , Patel Krish , Cameron C. Blake , Samsa Gregory P. , Roe Laura , Abernethy Amy P. , Zaas Aimee 
Published: November 2016

Context: In the emerging Learning Health System (LHS), the application and
generation of medical knowledge are a natural outgrowth of patient care. Achieving this
ideal requires a physician workforce adept in information systems, quality improvement
methods, and systems-based practice to be able to use existing data to inform future
care. These skills are not currently taught in medical school or graduate medical
education.Case Description: We initiated a first-ever Learning Health Systems Training
Program (LHSTP) for resident physicians. The curriculum builds analytical, informatics
and systems engineering skills through an active-learning project utilizing health
system data that culminates in a final presentation to health system
leadership.Findings: LHSTP has been in place for two years, with 14 participants from
multiple medical disciplines. Challenges included scheduling, mentoring, data
standardization, and iterative optimization of the curriculum for real-time instruction.
Satisfaction surveys and feedback were solicited mid-year in year 2. Most respondents
were satisfied with the program, and several participants wished to continue in the
program in various capacities after their official completion.Major themes: We adapted
our curriculum to successes and challenges encountered in the first two years.
Modifications include a revised approach to teaching statistics, smaller cohorts, and
more intensive mentorship. We continue to explore ways for our graduates to remain
involved in the LHSTP and to disseminate this program to other
institutions.Conclusion: The LHSTP is a novel curriculum that trains physicians to lead
towards the LHS. Successful methods have included diverse multidisciplinary educators,
just in time instruction, tailored content, and mentored projects with local health
system impact.
Climate Change in Hungarian Rural Society: Assessment of Adaptive Capacity
Authors: Vancsó Judit Pappné , Hoschek Mónika , Jankó Ferenc 
Published: November 2016

Abstract
Beside sustainable development, vulnerability might be the most frequently used expression in environmental studies. Vulnerability depends on the intensity of the impacts on a natural or social system as well as on its adaptive capacity. Appropriate adaptation warrants successful survival of the system even under high impact, when its vulnerability is significantly reduced; therefore, measuring adaptive capacity should have an established place in the methodology of impact – adaptation – vulnerability research. The main problem is to find relevant data that are required to establish indicators. In our study, the focus was laid on measuring adaptive capacity within vulnerability research, and on identifying possibilities for accurate calculation of adaptation. An attempt was made to determine the adaptive capacity to droughts in the micro-regions of Zala County. It could be established that the adaptive capacity of the population in the rural areas of Zala County to the expected increase in drought frequency is very low, which can be primarily explained by the lack of knowledge about adaptive agriculture.
On local rigidity of partially hyperbolic affine ℤ
k
actions
Authors: Damjanović Danijela , Fayad Bassam 
Published: November 2016

Abstract
The following dichotomy for affine

ℤ
k

\mathbb{Z}^{k}

actions on the torus

𝕋
d

{\mathbb{T}}^{d}

,

k
,
d

∈
ℕ

k,d\in{\mathbb{N}}

, is shown to hold: (i) The linear part of the action has no rank-one factors, and then the affine action is locally rigid. (ii) The linear part of the action has a rank-one factor, and then the affine action is locally rigid in a probabilistic sense if and only if the rank-one factors are trivial. Local rigidity in a probabilistic sense means that rigidity holds for a set of full measure of translation vectors in the rank-one factors.
Environmental Factors’ Consideration at Industrial
Transportation Organization in the «Seaport – Dry
port» System
Authors: Muravev Dmitri , Rakhmangulov Aleksandr 
Published: November 2016

Abstract
Currently, container shipping development is directly
associated with an increase of warehouse areas for
containers’ storage. One of the most successful types of
container terminal is an intermodal terminal called a dry
port. Main pollution sources during the organization of intermodal
transport are considered. A system of dry port
parameters, which are recommended for the evaluation
of different scenarios for a seaport infrastructure development
at the stage of its strategic planning, is proposed in
this paper. The authors have developed a method for determining
the optimal values of the main dry port parameters
by simulation modeling in the programming software Any-
Logic. Dependencies thatwere obtained as a result of modeling
experiments prove the adequacy of main selected dry
port parameters for the effective scenarios’ evaluation of
throughput and handling capacity at existing seaports at
the stage of strategic planning and a rational dry port location,
allowed ensuring the improvement of the ecological
situation in a port city.
Entropy as a measure of mixedupness of realizations in child speech
Authors: Babatsouli Elena , Ingram David , Sotiropoulos Dimitrios A. 
Published: November 2016

AbstractTypical morpho-phonological measures of children’s speech realizations used in the literature depend linearly on their components. Examples are the proportion of consonants correct, the mean length of utterance and the phonological mean length of utterance. Because of their linear dependence on their components, these measures change in proportion to their component changes between speech realizations. However, there are instances in which variable speech realizations need to be differentiated better. Therefore, a measure which is more sensitive to its components than linear measures is needed. Here, entropy is proposed as such a measure. The sensitivity of entropy is compared analytically to that of linear measures, deriving ranges in component values inside which entropy is guaranteed to be more sensitive than the linear measures. The analysis is complemented by computing the entropy in two children’s English speech for different categories of word complexity and comparing its sensitivity to that of linear measures. One of the children is a bilingual typically developing child at age 3;0 and the other child is a monolingual child with speech sound disorders at age 5;11. The analysis and applications demonstrate the usefulness of the measure for evaluating speech realizations and its relative advantages over linear measures.
About the Benefits of Pleasure-in-Others’-Misfortune. Aaron Ben-Ze’ev’s Depiction of Emotions as Adaptive Mechanisms
Authors: Michalik-Jeżowska Magdalena 
Published: November 2016

Abstract
This paper was inspired by two ideas: (1) the concept of emotions as adaptive mechanisms, which was suggested by Aaron Ben-Ze’ev, and (2) Robert Solomon’s criticism of the distinction between “positive” and “negative” emotions which functions in social sciences. In the context of the above mentioned theoretical perspectives I consider the infamous emotion of pleasure-in-others’-misfortune in terms of possible benefits for the experiencing subject. I focus especially on supposed adaptive quality of pleasure-in-others’-aging.
Searching for Neurobiological Foundations of Faith and Religion
Authors: Weker Maria 
Published: November 2016

AbstractConsidering that the brain is involved in human thinking, feeling and behaviour, we must also ask the question of whether finding neural correlates of religious experience is not just a matter of time. The questions ‘if’ and ‘how’ human brain responds to or generates religious experience capture the interest of researchers from various fields of science. Their joint efforts and scientific discourse lead to implementation of bold interdisciplinary research projects, with a far-reaching goal of explaining the mystery of faith and religion. Studies conducted at the meeting point of empirical and theological sciences raise controversies and criticism. Examples include the discussions on natural and theological experiments, collectively called neurotheology.
Hyperinsulinemic hypoglycemia associated with insulin antibodies caused by exogenous insulin analog
Authors: Su Chih-Ting , Lin Yi-Chun 
Published: November 2016

Summary
Insulin antibodies (IA) associated with exogenous insulin administration seldom caused hypoglycemia and had different characteristics from insulin autoantibodies (IAA) found in insulin autoimmune syndrome (IAS), which was first described by Dr Hirata in 1970. The characteristic of IAS is the presence of insulin-binding autoantibodies and related fasting or late postprandial hypoglycemia. Here, we report a patient with type 1 diabetes mellitus under insulin glargine and insulin aspart treatment who developed recurrent spontaneous post-absorptive hyperinsulinemic hypoglycemia with the cause probably being insulin antibodies induced by exogenous injected insulin. Examinations of serial sera disclosed a high titre of insulin antibodies (33%, normal <5%), high insulin concentration (111.9 IU/mL) and undetectable C-peptide when hypoglycemia occurred. An oral glucose tolerance test revealed persistent high serum levels of total insulin and undetectable C-peptide. Image studies of the pancreas were unremarkable, which excluded the diagnosis of insulinoma. The patient does not take any of the medications containing sulfhydryl compounds, which had been reported to cause IAS. After administering oral prednisolone for 3 weeks, hypoglycemic episodes markedly improved, and he was discharged smoothly.

Learning points:

Insulin autoimmune syndrome (IAS) or IAS-like situation should be one of the differential diagnosis in patients with hyperinsulinemic hypoglycemia.

Although less reported, insulin antibodies (IA) caused by exogenous insulin analog should be considered as the cause of hypoglycemia.

Patients with suspected insulin autoimmune syndrome (IAS) should be screened for drugs related to autoimmunity to endogenous insulin.
Aktualioji literatūra manifestų atspindyje (V. Rasputino „Mano manifestas“, V. Jarofejevo „JPS mokymas“ ir S. Šargunovo „Gedulo neigimas“)
Authors: Ковтун Наталья 
Published: November 2016

Straipsnyje, pasitelkus lyginamąją charakteristiką, nagrinėjami pagrindinių šiuolaikinės rusų literatūros krypčių – tradicionalizmo, postmodernizmo ir „naujojo realizmo“ – manifestai. Nors šiuolaikinėje literatūroje postmodernizmo įtaka akivaizdi, tačiau jau pirmo XX a. dešimtmečio viduryje prasideda aktyvios kitokios meninės kalbos paieškos. Todėl literatūros manifestų tarpusavio lyginimas tampa ypatingai aktualus. Taip aiškiai atsiskleidžia literatūros krypčių specifika, padedanti suvokti prieštaringą šiuolaikinės literatūros paveikslą. Jei teigsime, kad „meninės mokyklos ir stiliai vieni nuo kitų skiriasi pagal tai, kaip jie supranta Dievą, pasaulį ir žmogų“, tai, kalbėdami apie manifestus, iš esmės kalbame apie požiūrį į pagrindines būties vertybes, jų transformaciją skirtingais kultūros periodais. Manifestų palyginimas atskleidžia, kad „naujajame realizme“, vienoje iš dažniausiai šiandien aptarinėjamų rusų prozos krypčių, postmodernizmo poetikos elementai dera su pagrindinėmis tradicionalizmo temomis ir idėjomis. O asmeniniai autorių mitai kuriami, atsižvelgus į masinės kultūros funkcionavimo principus.
Restoring the natural smile with minimal intervention
Authors: Fialho Fernando Pinheiro , Firoozmand Leily Macedo 
Published: November 2016

Objective: Depending on the degree of saturation and time that pigments have been in the dental tissue, teeth with severe color change may have a poor prognosis for bleaching treatment.Case Report: In the reported case, after a careful clinical history and evaluation of clinical case a conservative treatment with composite resin restoration was carried out on superior central incisor with severe darkening. Direct composite resins with different opacity and translucency in association with resin pigments and a conservative technique were used guaranteeing a minimal intervention and giving a natural aspect to the tooth. The use of pigments made possible less wear of dental structure for insertion of the composite resin, mimetizing the restored tooth with the corresponding teeth.Conclusion: It was concluded that in some cases where indirect restorations would be indicated, when different kinds of dental materials and techniques are applied, direct restorative treatment would be a great option for esthetic restorations.
Oral manifestations in chronic kidney failure patients
Authors: Reis Renata Cristina Canuto , Brancher João Armando , Deliberador Tatiana Miranda , Guimarães Ana Tereza Bittencourt , Giovanini Allan Fernando , Zielak João Cézar 
Published: November 2016

Objective: Chronic kidney failure (CKF) is a progressive deterioration of the kidneys. The goal of this study was to analyze the oral manifestation of CKF in a sample of hemodialysis and transplanted patients.Methods: Eighty-three records of patients treated in the Pro-Renal Foundation in Curitiba, Brazil were used. The records were separated in four groups: Transplanted Men (TM = 14), Transplanted Women (TW = 18), Men in Hemodialysis (MHD = 28) and Women in Hemodialysis (WHD = 23). Information about oral and systemic health condition were collected. Data from each group were submitted to correspondence analysis and quantitative variables were compared by Kruskal-Wallisand Dunn’s test. Significance level was 0.05.Results: Gingival inflammation, loss of periodontal support tissue, dental calculus and increase in periodontal probing depth were common findings in all patients, but significant association was found in following groups: TM presented dental calculus; TW presented a high prevalence of cardiovascular problems and saburral tongue; MHD presented poor oral hygiene, gingivitis associated with smoking; WHD presented a high prevalence of temporomandibular dysfunction.Conclusions: The most prevalent findings were increase in the periodontal probing depth and gingival recession. Unexpectedly, WHD group presented a high prevalence of temporomandibular dysfunction.