bluuebunny/crossref_metadata_2025_split huggingface dataset:
C-reactive protein levels are related to suicidality in euthymic patients with bipolar disorder
Authors: Pantovic Stefanovic M. , Dunjic-Kostic B. , Lackovic M. , Damjanovic A. , Jovanovic A. , Totic-Poznanovic S. , Ivkovic M. 
Published: May 2016

IntroductionImmune alterations are believed to be an important part in etiopathogenesis of affective disorders. However, it is not clear if the altered immune mediators are related to distinct disorders or particular psychopathology.AimsThe aim of our study was to explore the differences in C-reactive protein levels (CRP) between euthymic BD patients and healthy controls, as well as to explore the relationship between CRP and lifetime presented psychopathology within BD.MethodsThe study group consisted of 83 patients diagnosed with BD, compared to the healthy control group (n = 73) and matched according to age, gender, and body mass index (BMI). Lifetime psychopathology has been assessed according to predominant polarity as well as previous history of suicide attempts and psychotic episodes.ResultsThe CRP levels were significantly higher in BD patients when compared to healthy controls. After covarying for confounders, we observed that CRP levels, in euthymic BD patients, were related to number of previous suicide attempts, but not other indicators of lifetime psychopathology.ConclusionsBD patients per se, and particularly those with more suicide attempts, are more likely to present with proinflammatory state, even when in remission. Previous history of suicide attempts could bear specifically vulnerable endophenotype within BD. Systemic, longitudinal monitoring of the course of illness, and potential inflammatory mediators that underlie its systemic nature is warranted.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Psychotic mixed state in bipolar I disorder due to neurosyphilis: Case report and literature review
Authors: Preve M. , Godio M. , Suardi N.E. , Traber R. , Colombo R.A. 
Published: May 2016

IntroductionThe presence of mixed features in bipolar disorder (BD) has been associated with a worse clinical course and high rates of comorbidities including anxiety, personality, alcohol and substance use disorders and head trauma or other neurological problems [1]. A recent study reports the connection of neurosyphilis and mania [2]. The aim of our study is to evaluate an inpatient with a psychotic mixed state due to a medical condition (neurosyphilis).MethodAn inpatient with psychotic mixed state in BD was assessed with: SCID-P, HRSD, YMRS, and a complete internistical examination, blood test exams, urinanalysis, electrocardiogram and ecocardiogram, as well as a first level brain imagin (CT and/or MRI). We conducted a systematic review of the literature (PubMed, Embase, PsychInfo), using the terms “bipolar disorder”, “neurosyphilis” AND “mixed state”.ResultsA comprehensive diagnostic and laboratory screening was unremarkable except for a positive venereal disease research laboratory (VDRL). Treatment for syphilis was started and we used olanzapine to control the psychiatric symptoms.Discussion and conclusionThe estimated annual incidence of non-HIV STIs (sexually transmitted infections) has increased by nearly 50% during the period 1995–2008 [3]. Our case report underly, like Barbosa et al., the need to evaluate neurosyphilis as a potential cause of behavioural and psychiatric symptoms that simulate a psychotic mixed state of bipolar disorder. Olanzapine control and improve the psychiatric symptomatology in neurosyphilis. Methodological limitations, clinical implications and suggestions for future research directions are considered.Disclosure of interestThe authors have not supplied their declaration of competing interest.
First episode of bipolar depression after systemic lupus erythematosus in a 51-year-old woman
Authors: Tardelli V. , von Nielander L. , Sarin L. , Del Porto J.A. 
Published: May 2016

IntroductionSystemic lupus erythematosus (SLE) is a multisystem disease with a broad spectrum of clinical features and neuropsychiatric manifestations that occur in up to 60% of patients. Disease activity and treatment with corticosteroids may contribute to this higher risk. It is also known that 36% of patients with SLE and comorbid Bipolar Disorder (BD) have had their psychiatric onset after they had been diagnosed with SLE.MethodSingle case report.ResultsA 51-year-old woman received a diagnosis of SLE 24 months before the beginning of depressive symptoms. After her diagnosis of SLE, seven years ago, she had three suicide attempts, being diagnosed with major depressive disorder. From them on, she had crises characterized by well-defined periods of 7 to 10 days with sadness, reduced need for sleep, social isolation, irritability, anger outbursts, impulsivity, racing thoughts and suicidal ideation. After treatment with mood stabilizers (quetiapine 300 mg/day and lithium 600 mg/day), she had a substantial reduction of symptoms intensity and frequency.ConclusionThe link between immune dysregulation, autoimmunity and bipolar disorder may be closer than previously thought. Even if the autoimmune disease is not directly etiologically related to the psychiatric presentation, its detection is important due to the high morbidity and mortality, considering the current understanding that Bipolar Disease is strongly related with inflammation in central nervous system.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Psychological experiences reported by offsprings of mothers with bipolar disorder: A clinical-qualitative study in a Brazilian university outpatient service
Authors: Campos L.K.S. , Santos A. , Garcia C. , Turato E.R. 
Published: May 2016

IntroductionChildren of patients with bipolar disorder are at increased risk of developing psychopathology and psychosocial difficulties.ObjectivesTo understand the emotional experiences of adult children of mothers with bipolar disorder.MethodQualitative study, using in-depth semi-directed interviews with open-ended questions, sample closed by saturation information criteria, content analysis, discussion under psychodynamic concepts.ResultsFrom interviewees’ reports, it can be seen that offspring's experiences emotional vulnerability, such as directions given by early exposure to self injurious behaviour, psychiatric hospitalizations, routine absences from home and consequent perception of helplessness, especially in periods of the mother's crisis. The findings suggest that for the children the insecurity to assume the precociously inverted responsibility regarding the need of care to mother seems to experience by them as an entrapment to the care of the mother, for the effort they make to keep them alive, with an emotional burden due to both impaired childhood and adolescent.ConclusionIt was analyzed the assumption that the evolution of reactive psychological stages regarding the mother affected by a mental illness marked by bipolarity manifestations, alternating with phases of the normality of psychic manifestations, would follow the evolution of the oscillating psychological stages of his/her own mother, which minimizes often both the disease and the treatment during the phases of remission of manifestations.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Fecundity and bipolar spectrum disorder
Authors: Vieira J. , Salta M. , Barata B. , Nogueira J. , Sousa R. , Costa R. , Madruga L. , Mendes R. , Mendes S. , Ribeiro B. , Ribeiro R. , Gamito A. 
Published: May 2016

IntroductionFertility and fecundity are usually considered signs of social and emotional well-being. Bipolar disorder (BD) is a prevalent psychiatric disease that influences the individual's life style and behaviours. Some studies have addressed the issue of fecundity among women with bipolar disorder but few have focused on determining the differences between disease subtypes, which is expected, taking into account the studied differences in demographic measures.ObjectivesTo examine the fecundity of a population of women with bipolar disorder.AimThe aim of this study is to compare the fecundity among women diagnosed with subtypes I to IV of BD, according to Akiskal's bipolar spectrum disorder classification.MethodsA total of 108 female outpatients were divided into four groups. We analyzed number of offspring and demographic features between patients with different subtypes of BD using multivariate analyses.ResultsOur results showed a significantly higher average number of children for BD IV patients when compared with BD I patients. Although not reaching statistical significance, BD I patients had less offspring than BD II and BD III patients. BD I patients had lower marriage rates compared to the other groups.ConclusionsOur results suggest that the subtype of bipolar disorder influences fecundity and behaviours, as is expressed by the lower number of marriages seen in BD I patients. We found that fecundity is significantly impaired among BD I patients, which may imply that female with more severe disorders are less likely to become parents. Fecundity is higher among BD IV patients, which makes a way to speculate about the adaptive role of hyperthimic temperamental traits.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Mental health care to children and adolescents
Authors: Alonso Díaz R. , Cortázar Alonso E. , Guillén Rodrigo H. , Remesal Cobreros R. , Fuentes Márquez S. 
Published: May 2016

Unit Mental Health Day Hospital Child and youthful, is a device of tertiary health care, integrated into the UGC Mental Health, led to intensive treatment of children and young people in the province of Huelva, with severe mental illness and who need specialized medical care.To first access to this unit, the person should be referred for specialized Pediatrics; by your psychiatrist or psychologist benchmark for mental health teams; or from the Hospitalization Unit, as it is a third-level device.When a patient was diagnosed with eating behavior disorder (TCA) is derived, an initial consultation with the child and parents, a first psychiatric evaluation, also by nutritional and Endocrinology Nursing is performed. After evaluation of these professionals, you can take the decision to begin an intensive outpatient treatment in which the patient would have frequent consultations with the psychiatrist, the nurse and endocrine.They may also decide inpatient hospitalization and this could be partial, to be held in the Day Hospital; or all, if the patient is under 14 years and hospitalization for psychiatric criteria indicated; the patient would enter Pediatrics. If he is over 14 years old, would join Hospitalization Unit.In Child and Adolescent Hospitalization Unit of Huelva patient it is included in a specific program for TCA where a psychiatric, endocrine, educational approach in the classroom is done. Coordination meetings with education, social services and early care centers that are also in contact with that child are also conducted.Disclosure of interestThe authors have not supplied their declaration of competing interest.
The RDoC roadmap to explore neurocognitive difficulties of youths with severely dysregulated mood: Current findings and prospects
Authors: Benarous X. 
Published: May 2016

The Research Domain Criteria (RDoC) has been developed as a multilevel approach to study neurocognitive impairments in psychiatry. Considering the high prevalence and the functional impairment associated with disruptive mood dysregulation disorders (DMMD) in youths, a better understanding of the neurobiological mechanisms underlying such emotional difficulties could help guide therapeutics.So far, three key difficulties in the socio-emotional neurocognitive process have been documented in youths with DMDD:– a deficit in the recognition of facial emotions has been found (systems for social process/social communication construct). Functional imagery has shown that such impairment is associated with a hypoactivity of limbic neural structures, especially the amygdala. Such findings are in line with those found in adults with depressive episodes;– poor flexibility during cognitive tasks (cognitive systems/cognitive effortful control construct). In particular, these youths score poorly in neuropsychological tasks associated with response reversal paradigm measuring the capacity to change cognitive strategy when the rules of the game change implicitly. These results partly explain the difficulties facing DMDD youths in a frustrating context;– higher level of emotional arousal. Such youths would present specific impairments in the initial stages of attention; reflected by lower N1 event-related potential amplitude during Posner affective tasks.Ongoing studies are being conducted to explore other RDoC domains such as abnormalities in circadian rhythms; in metacognition and perspective-taking tasks; and in the non-facial communication process (such as prosody or postural expressions). A computational model of interactive behaviors is a promising field to study difficulties of DMDD youths in regulating moods during social interaction.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Childhood adversities and emergency room visits
Authors: Samsó B. , Alba L. , Chavarria V. , Sanchez B. , Pardo M. 
Published: May 2016

IntroductionInstitutionalized children and adolescents who reside in foster centres are a subgroup of population that use mental health resources. This group of population has an increased risk of physical and psychopathology health problems. That translates into a greater number of emergency visits. This is the same perception presented by different professionals.ObjectivesThe aim of the study is to analyse visits to emergency child and adolescent psychiatry service from a pediatric hospital. Also ask for a point of view of the professionals about it.MethodsWe select all the patients attended the emergency psychiatry child and adolescent care that were institutionalized. The sample was collected for 4 months in a pediatric hospital.Resultsn = 66 (51.5% male; mean age 14.09 ± 1.95 years old), 31.8% was the first time at the emergency room, 31.8% had consulted between 2–4 times and 36.4% over 4 times. The main reason for consultation was aggressiveness (66.7%). The three main discharge diagnoses were conduct disorder (50%), adjustment disorder (25.7%) and TDAH (7.5%) The 45.5% had a history of drug use and the 24.2% of self-harm. Asking professionals 80% responded perception of increased emergency consultations and the 90% think inadequate value between 50–70% of queries.ConclusionsThe boys institutionalized perform a high use of paediatric and psychiatric emergencies. There are a significant number of re-consultations. Professionals have the perception that their emergency visits are increasing. Since patients are at high risk of suffering mental disorders and high use of emergency would be interesting to develop specific protocols for emergency care for these groups.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Relationship between coping and anxiety in young university population
Authors: Cabas-Hoyos K. , German-Ayala N. , Nadia E.D.L. , Loreina M.B. , Alicia U.U. 
Published: May 2016

In Latin American countries the University Entrance occurs before 17 years of age, in adolescence. The literature proposes some tasks of this stage as the search for identity and definition of the plan of life (Casullo et Fernández-Liporace, 2001). This stage is characterized by changes that may lead to stress (Frydenberg et Lewis, 1991) and strategies and styles should be deployed to deal with situations surpluses. The aim of this paper is to explore the relationship between coping styles and anxiety in young university students.The total sample consisted of n = 216 university students (53.2% female, n = 115, 46.8% male, n = 101; between 16 and 18 years of age: m = 17.32, SD = 0.70). The subjects answered the ACS (Frydenberg, 1997) which assesses coping styles in young people and the AMAS-E (Reynolds, 2007) assessing anxiety. The design was corelational, the data were analyzed using SPSS 21.0 statistical program.Results and discussionAs used style Troubleshooting reduces test anxiety, the tendency of these two variables is negative (P = 0.01). Implement the style Relating to others it will decrease test anxiety, the tendency of both variables is negative and statistically significant (P > 0.05). Stress in young people increases as gets underway unproductive type (P = 0.00). The results are consistent with the literature that suggests that late adolescents in academic challenges cause such hardship (Marote et Martínez, 2001).Disclosure of interestThe authors have not supplied their declaration of competing interest.
Hoarding disorder and obsessive-compulsive disorder
Authors: De la Torre Brasas F. , Duque Domínguez A. , Echeverría Hernández N. , Lázaro Redondo M.D.M. , García Montero C. , Otalora Navarro M. , Martín Díaz L. , Más Villaseñor A. 
Published: May 2016

IntroductionHoarding disorder is described in the DSM-5 as a new clinical entity whose essential characteristic is the persistent difficulty discarding or parting with possessions, regardless of their actual value, arguing reasons of utility, aesthetics, attachment or strong fear of losing Information.ObjectivesWe present the case of an 11-year-old male patient brought to the Health Mental office when his mother found in the school bag debris that he had collected from the garbage, and useless objects in a bedroom drawer. The patient recognizes the nonsense of his behaviour but is unable to get rid of these objects but he allows his mother to do it. He had lowered school performance and showed irritable, shy and solitary, difficulties to sleep and cried often without apparent reason. They also noted since six months before, strange movements with the neck and eyes.MethodsAfter ruling out, underlying organic pathology, we started treatment with sertraline 50 mg, aripiprazole 2.5 mg and cognitive behavioural therapy, with complete disappearance of symptoms including the movement disorder.ResultsObsessive compulsive disorder 300.3 (F42); Hoarding disorder 300.3 (F42); Provisional Tic disorder 307.21 (F95.0).ConclusionsHoarding behaviour of strange objects is very unusual in Hoarding Disorder but more common in the Obsessive-Compulsive Disorder. In this case report, we consider the possibility of both disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.
From ADHD to psychosis… executive functions and time
Authors: Isabel C.D.M. 
Published: May 2016

IntroductionCognitive impairment is present from the early stages of psychotic disorders. Alterations are found mainly in areas of attention, memory work and executive functions. During adolescence, ADHD patients often suffer from secondary disorders to lack of efficient procurement processes information by the poor development of executive functions.ObjectiveEvaluation of a patient whose diagnosis of ADD evolve to acute psychotic episode.MethodReview by clinical and psychometric tests developments in executive functions disorders.ResultsTwelve years old patient who comes to the hospital since 2012, was initially diagnosed with literacy difficulties and low academic performance, after MFF-20 speaks of Learning Disabilities. It presents lack of motivation, apathy, difficulty in scheduling and organization and adherence to schedules, so they diagnosed ADD. It is given treatment with methylphenidate and atomoxetine, presenting erratic path.After a year without treatment and the presence of a major stressful life event, at 17, has a first episode, consisting in mutiste attitude, phenomena of self-referenciality, experiences of control, enforcement and dissemination of ideas and auditory hallucination imperative type.ConclusionsThe presence of emocional dysregulation and alterations in the executive functions atribuyen to ADD, in this case, were premorbid symtomatology of a first psychotic episode. The presence of positive symptoms allows to clarify the diagnosis.Disclosure of interestThe authors have not supplied their declaration of competing interest.
Delayed memory in ADHD children
Authors: Lvova O. 
Published: May 2016

IntroductionIt is known that children with ADHD have deficit in cognitive abilities. However there are different opinions about the nature of this deficit. It is necessary to conduct researchers for revealing specific profile of impairments in different cognitive domains in ADHD children to better understanding the nature of this disorder.AimsThe aim of this research was to examine the hypothesis that children with ADHD have a specific deficit in memory – weakness in delayed memory.MethodsThe experimental group included 15 Russian-speaking children with ADHD at age 7–8 years. The control group included 15 typically developing children. The children from experimental and control group were matched for IQ, gender and age. Children from both groups were assessed with NEPSY using memory for names subtest. This subtest is designed to assess the ability to learn the names of children in immediate and delayed conditions. Two-way ANOVA was used to reveal group differences in reproducing the names in two conditions.ResultsWe have not revealed significant differences between children from experimental and control group in the reproducing the names in immediate condition.However, the interaction of condition type and group was significant (P ≤ 0.05). ADHD children were less successful in reproducing the names in delayed condition.ConclusionsIn view of the obtained results, it can be assumed that children with ADHD have specific deficit in memory domain – weakness in delayed memory. It is necessary to confirm this result using different memory tasks.Disclosure of interestThe authors have not supplied their declaration of competing interest.
A bizarre love
Authors: Noval Canga C. , Hernández Antón R. , Cepedello Pérez S. , Gómez Sánchez S. , Rodríguez Andrés L. , Gallardo Borge L. , Medina Ojeda G. , Alonso Sánchez A. , Álvarez Astorga A. , Portilla Fernández A. 
Published: May 2016

IntroductionAdoption constitutes a discontinuity in child care trajectory, that falls into a separation and a lost of reference figures, and therefore, the need to set up new attachment figures into a suitable familiar atmosphere.ObjectivesThis case is a review of how a child adoption process, that can be something positive at first, can also produce many problems in the future, added to dificulties in order to regulate stressing situations and also solving problems.MethodsThe clinical case consists in a 25-year-old woman, who suffers from anxiety and self-injure behaviour. She has a diagnosis of non-specified personality disorder with limit characteristics. The patient was adopted a few months after her birth. At the moment she's living with her adoptive father, her adoptive mother passed away when she was 4. At the age of 21, the patient meets her biological mother and since that moment she spends most of the weekends with her. After a few medical appointments, she admits that she has allowed sexual relationships with her biological mother since six months ago.ResultsIt's important to appreciate the value of familiar atmosphere, and in addition, the attachment between child and his parental figures. The quality of the attachment is going to have influence in emotional regulation.ConclusionsChildren who have suffered neglect from their biological parents and have been adopted develop attachment behaviours characterized by negative experiences. In spite of being in a good familiar environment, they feel vulnerable and insecure. Early and appropriate attachment experiences can improve relationships between children and their new family.Disclosure of interestThe authors have not supplied their declaration of competing interest.