bluuebunny/crossref_metadata_2025_split huggingface dataset:
PITFALLS IN USING INTRAVASCULAR IMAGING DURING PCI: SIZING THE STENT ACCORDING TO MEAN ARTERIAL LUMEN DIAMETER MAY RESULT IN STENT UNDEREXPANSION
Authors: Suslov Ivan V. , Pekarskiy Stanislav E. , Baev Andrey E. , Tarasov Mikhail G. , Gergert Egor S. , Gromovoy Roman M. , Bogdanov Yuri I. , Sultanov Syrgak M. , Gorokhovsky Alexey A. , Ivashkin Denis O. 
Published: October 2024

HighlightsContemporary algorithms for optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) are easy to learn and understand, however, these algorithms are mostly declarative, and not substantiated in practice. In particular, using the mean reference lumen diameter may result in underestimation of the optimal stent size in relation to the degree of stenosis, i.e., the difference between the minimum and maximum diameters (lumen asymmetry), whereas choosing a stent based on the mean lumen diameter leads to stent underexpansion. Aim. To assess whether choosing a stent size based on the mean lumen diameter of the reference segment of the artery may result in its underexpansion.Methods. The prospective cohort study included patients with chronic coronary artery disease and complex lesion anatomy who underwent high-risk OCT-guided PCI. Based on the OCT results, the distal and proximal reference segments were determined, in which the minimum and maximum diameters were measured, followed by calculating the mean lumen diameter, which was further used for stent selection. Based on the results of repeated OCT after stent implantation, the degree of stent expansion was assessed. The expected relationship between the degree of stent expansion and the baseline lumen asymmetry was assessed by correlation analysis. Linear regression was used to determine the asymmetry threshold corresponding to clinically relevant stent expansion of 80%.Results. Overall, 24 patients were enrolled, 3 of them were excluded because of inability to perform OCT without lesion predilatation. On average, the maximum and minimum diameters of the reference lumen according to OCT were 2.87 ± 0.66 mm and 1.85 ± 0.44 mm, respectively. The ratio between minimum and maximum diameter was 0.35 ± 0.09. The mean diameter was 2.30 ± 0.51 mm, the difference between the maximum and mean diameters was 0.61 ± 0.28 mm. The criterion of stent expansion ≥ 80% was achieved in 6 cases (28.6%). The correlation analysis has shown a statistically significant inversely proportional dependence of the relative stent expansion on the baseline lumen asymmetry (the difference between the maximum and minimum diameters (r = –0.41, p = 0.032), while clinically relevant stent expansion ≥ 80% was observed with a relative difference in diameters of less than 30%Conclusion. In case of significant lumen asymmetry choosing a stent diameter based on the mean lumen diameter is associated with stent uderexpansion.
NON-DESTRUCTIVE METHOD FOR ASSESSING THE DEGREE OF CALCIFICATION IN BIOPROSTHETIC HEART VALVES
Authors: Klyshnikov Kirill Yu. , Glushkova Tatyana V. , Kostyunin Alexander E. , Rezvova Maria A. , Onishchenko Pavel S. , Akentyeva Tatyana N. , Batranin Andrey V. , Ovcharenko Evgeny A. 
Published: October 2024

HighlightsMicro-computed tomography allows specialists to qualitatively and quantitatively assess the structure of calcified areas of explanted bioprosthetic heart valves.This method enables the evaluation of changes in the structure of the bioprosthesis that have occurred during its prolonged operation. Aim of the study. To evaluate the potential of high-resolution tomography for the study of mitral valve bioprostheses of different designs explanted due to dysfunction and various calcification patterns (microcalcification and macrocalcification).Methods. Single samples of the «UniLine» and «PeriCor» bioprostheses were the objects of study, they were explanted due to dysfunction developed after 76 and 87 months of operation in recipients. The peculiarities of calcification localization in the structure of bioprostheses were studied using high-resolution tomography followed by reconstruction of volumetric images and quantitative analysis of radiodense areas. Moreover, we used light microscopy with Alizarin Red S staining to detect calcifications.Results. The study results showed that the nature of the distribution and volume of calcinates significantly differ between the studied samples: for the «UniLine» bioprosthesis, the affected areas were located in the leaflet material and constituted 21.1% of the total biological tissue volume; for the «PeriCor» bioprosthesis, calcifications were diffusely distributed in small structural formations, accounting for a total of 5.1% of the biological material, primary localized on the «auxiliary» structures of the prosthesis – the covering made of porcine or calf xenopericardium. In addition, high-resolution tomography allowed us to determine the degree of deformation of the «UniLine» bioprosthesis frame, with the posts deviating inward by 1.1–1.4 mm.Conclusion. The possibility of using computed microtomography for qualitative and quantitative assessment of calcified xeno-pericardial and xeno-aortal bioprostheses has been demonstrated. However, this method is limited in its ability to detect macrocalcification within the leaflet thickness.
THE EFFECT OF VARIOUS COMPOSITE COATINGS OF TITANIUM MATRIX ON OSTEOGENIC DIFFERENTIATION OF INTERSTITIAL CELLS OF THE HUMAN AORTIC VALVE
Authors: Boyarskaya Nadezhda V. , Kachanova Olga S. , Shishkova Anastasia A. , Uspenskij Vladimir E. , Filippov Alexey A. , Tolpygin Dmitry S. , Lobov Arseniy A. , Malashicheva Anna B. 
Published: October 2024

HighlightsThe study involves experiments with titanium substrates with various composite coatings. The aim of the study was to assess different methods of diagnostics of artificial implant materials and evaluate the effect of coatings on osteogenic differentiation in interstitial cells of the human aortic valve. Background. Currently, the only medical treatment for aortic stenosis is aortic valve replacement. At the same time, calcific aortic stenosis is the third most prevalent cardiovascular disease that affects up to 10% of the population by the age of 80. In this regard, it is important to develop materials for aortic valve prostheses that would be highly biocompatible, chemically stable, non-thrombogenic, non-immunogenic and non-osteogenic.Aim. To assess the impact of composite coatings of titanium bases on osteogenic differentiation of valve`s interstitial cells and to analyze the methods of express diagnostics of artificial implant materials.Methods. The study examined titanium samples with three different coatings. The interstitial cells of the aortic valve were cultured on the studied materials. Using the PCR-RT method, the level of changes in the expression of osteogenic markers RUNX2, COL1a1, ALP under the influence of osteogenic stimuli was analyzed. To determine the level of calcification in cells, we stained the samples with alizarin red and conducted spectrophotometric analysis. Several RNA isolation methods were evaluated.Results. The most optimal RNA isolation method involves the use of a poly(A) tails. Moreover, we developed a protocol for the absorption of calcium from composite materials. We noted multidirectional changes in the expression of RUNX2, ALP, and COL1A1 genes in cells cultured on coated titanium samples compared to controls. The intensity of expression differed depending on the type of coatings; these data correlated with the intensity of staining with alizarin. Thus, different types of coatings affect the processes of osteogenic differentiation in cells in different ways.Conclusion. The duration of express diagnostics was 21 days and included the study of gene expression of osteodifferentiation markers at a time point of 96 hours and staining with alizarin red on day 21 from the start of osteodifferentiation. It has been established that polymer coatings affect osteogenic differentiation, however, all the studied coatings cannot be recommended for valve prostheses, it is advisable to use them to enhance osteogenic processes.
CHANGES IN THE NUMBER OF CORONARY BYPASS SURGERY IN SOME REGIONS OF THE RUSSIAN FEDERATION IN 2019–2021
Authors: Semenov Vladimir Yu. , Kovalenko Oleg A. 
Published: October 2024

HighlightsThe number of coronary bypass surgeries in the Russian Federation in 2021 has remained below the 2019 indicator.The highest territorial accessibility of open-heart surgery is noted in the Volga Federal District.There number of open-heart surgeries performed does not depend on the capacity of the medical organization. Aim. To study the changes in the number and outcomes of coronary artery bypass surgeries in the Russian Federation during 2019–2021 on the example of the Central, Volga and North Caucasus Federal Districts.Methods. We used data from the following sources: official statistics published by the Ministry of Health of the Russian Federation (Statistics Form No. 14); data published by Federal State Statistics Service; data on patients from “A.N. Bakulev National Research Center for Cardiovascular Surgery”; official statistics published by the Organization for Economic Co-operation and Development; and the available literature data. Taking into account the demographic characteristics of the regions, we calculated the number of surgeries per 100.000 citizens.Results. The total number of CABG decreased by 18.7% in 2020 (from 9 739 in 2019 tо 7918 in 2020) in the studied subjects of the Russian Federation. There was an increase in the number of direct myocardial revascularization in 2021 by 8,6% compared to 2020. However, this index was still 11.7% lower as compared to 2019. The number of CABG per 100,000 population in the regions was 24,6 ± 18,6; 21,0 ± 16,2 and 22,9 ± 17,8 in these years, respectively. At the same time, it should be noted that the decrease in the number of open-heart surgeries did not depend on the capacity of medical organization. The analysis also showed that in 2020, the average mortality rate during CABG increased by 5.6% compared to 2019 (from 1.8 ± 1.5 to 1.9 ± 1.6).Conclusions. In 2020, the number of planned coronary artery bypass surgeries in the Central, Volga and North Caucasus Federal Districts of the Russian Federation decreased by 18,7% on average compared to 2019 with a slight positive trend in subsequent years. One of the most likely reasons is coronavirus disease pandemic.
Improvements and Heterogeneities of the Global Centroid Moment Tensor Catalog
Authors: González Álvaro 
Published: October 2024

Abstract
Earthquake catalogs are heterogeneous, especially those developed over long time spans. Changes in seismological monitoring, which provides the records on which these catalogs are based, are common. Typically, instruments and networks become more sensitive over time, allowing for the detection and characterization of smaller earthquakes. In pursuit of improvement, new methods for routine data analysis are occasionally introduced, modifying the procedures for catalog compilation. The resulting heterogeneities may not be evident to users, but they should be unveiled and considered in any application of the catalog, especially in statistical seismology, which analyzes large earthquake data sets. The Global Centroid Moment Tensor catalog is considered the most homogeneous database of global seismicity. However, a detailed analysis of its heterogeneities has been lacking. This work reviews changes in the catalog’s development from 1976 to 2023 and reveals how these have caused improvements and heterogeneities in the resulting data. Several periods are distinguished, separated by milestones in the methods employed for moment tensor inversion and catalog compilation, as well as by the advent of global broadband monitoring in 2004. These changes are shown to have caused variations in the catalog’s completeness and in the determinations of centroid depths, scalar seismic moments, and moment tensors. The magnitude of completeness is measured here in detail, both temporally and spatially. It has decreased over the years and shows spatial variations within each period, correlated to regional differences in network monitoring and compilation biases. Moment tensor determinations have been significantly different since 2004, resulting in a different frequency distribution of rake angles and a different dependence of the double-couple component as a function of rake. This work is expected to benefit all future uses of the catalog, enabling better characterization of seismicity properties and improved building and testing of models for earthquake occurrence.
Patient Adherence and Duration of Continuous Treatment With Various Arbs in Patients With Uncomplicated Arterial Hypertension in the USA Based on The Analysis of the Truven Health Analytics MarketScan Database
Authors: Belenkov Yu. N. , Glezer M. G. , Kozhevnikova M. V. , Chernichka K. S. , Matveev N. V. 
Published: October 2024

Aim. To discuss two aspects that can be used to improve the adherence to therapy in patients with arterial hypertension (AH): 1) which of the angiotensin II receptor blockers (ARBs) provides the highest adherence rates; 2) how various factors influence adherence rates.Material and methods. An analysis of one of the world's largest clinical practice databases, Truven Health Analytics MarketScan (currently Merative MarketScan), was performed. The analysis included data on patients of both sexes aged 30 to 65 years who had been diagnosed with uncomplicated AH (at least once between March 1, 2012 and January 1, 2018) and prescribed monotherapy with one of ARBs. The exclusion criteria were heart failure and the treatment with two or more ARBs (simultaneously or sequentially) during the treatment period. Ultimately, the study included 717,099 patients with uncomplicated AH, who were divided into four groups based on the prescribed drug: azilsartan (n=4276), candesartan (n=6023), losartan (n=586,857), and valsartan (n=119,943). Adherence to treatment was evaluated by two parameters: duration of continuous therapy and medication possession ratio (MPR). The individual effect of each factor (specific ARB used for therapy, patient gender, age, initial ARB dose, patient co-payment per day of treatment) on the adherence to treatment was assessed using a regression analysis.Results. The adherence to the ARB therapy was generally high. The MPR was the lowest in the azilsartan group and the highest in the candesartan group. However, the parameters that potentially influenced both the MPR and the duration of continuous therapy (patient’s gender and age, initial ARB dose, co-payment size) differed significantly between the groups receiving different ARBs. The regression analysis showed that both adherence parameters and the duration of continuous therapy were higher in patients receiving candesartan than in patients receiving azilsartan, losartan or valsartan, when the effect on the adherence of other factors available for study (age, gender, initial dose of the drug, and the absolute size of co-payment for a day of therapy) was excluded. The lowest adherence to therapy was observed in the azilsartan treatment group (p<0.01).Conclusion. The study provided data for comparing the adherence of patients with uncomplicated AH to the therapy with different ARBs. Further study of adherence to treatment will provide additional data that will allow an optimal selection of drugs for the treatment of AH in patients with potentially poor adherence.
Educação a Distância e o Curso de Educação Física: Desafios dos Discentes para com a Prática
Authors: Baumgärtner Lucas Vitor 
Published: October 2024

Com o passar do tempo, a internet tem ganhado cada vez mais espaço no mundo, não sendo diferente para o meio educacional. Atualmente, os cursos de EAD combinam várias TIC para o discente poder estudar. No currículo do curso de Educação Física licenciatura e bacharelado, existe uma proporção altíssima de demanda prática (derivado de estágios obrigatórios, disciplinas específicas como: natação, futebol, voleibol, anatomia humana, jogos e brincadeiras, danças, lutas etc.), sendo dificultosa e menos exitosa aplicando-se em uma modalidade EAD ou híbrida (semi-presencial). Sendo assim, este artigo teve como objetivo analisar as possíveis implicações que a falta de prática pedagógica traz para os discentes do curso de Educação Física licenciatura e bacharelado na modalidade EAD. A pesquisa classifica-se em sua abordagem como qualitativa, de natureza aplicada, com objetivo exploratório por meio de uma pesquisa de campo. Utilizou-se um questionário aberto e fechado como instrumento para geração dos dados. Como resultados, podemos ressaltar que a falta de prática pedagógica e a falta de carga horária presencial afeta diretamente o rendimento futuro no campo de atuação profissional destes sujeitos. E, o que faz um aluno optar pelo EAD ao invés do presencial é diretamente a relação entre tempo e dinheiro, ou melhor, valor acessível e tempo variável.

Palavras-chave: Ensino a distância. Educação física. Implicações.
Reflexões sobre a Sala de Aula Ampliada e o Comodale: Polígono Fedathi em Ação
Authors: Xavier Daniele de Oliveira , Carmo Fernanda Maria Almeida do , Borges Neto Herminio , Barbosa Jessica de Castro 
Published: October 2024

A evolução das tecnologias redefiniu as abordagens educacionais, proporcionando oportunidades inovadoras que visam aprimorar o ensino-aprendizagem. Destacam-se, com efeito, as webconferências, ferramentas-chave na Educação a Distância, que relativiza as relações, o tempo e o espaço da realidade educacional. O Ensino Comodale propõe o uso de webconferências para a realização de aulas simultâneas, ou seja, que ocorrem paralelamente na modalidade presencial e a distância. Mencionado procedimento oferece aos estudantes a flexibilidade para participar, sem qualquer prejuízo, das atividades acadêmicas presencial ou virtualmente. Com suporte nesses comentários, objetivou-se mostrar o Comodale MultiMeios, que se utiliza do Polígono Fedathi e dos preceitos do Ensino Comodale para promover flexibilidade, interação e participação ativa dos estudantes. O estudo é classificado como pesquisa-ação, em que a observação participante foi utilizada como coleta de dados. Desse modo, uma disciplina de pós-graduação foi ofertada na modalidade presencial, realizando, conjuntamente, transmissões simultâneas por meio de uma plataforma de webconferência inserida no Moodle MultiMeios. Comprovou-se o comprometimento do docente em valorizar e incentivar a participação de todos os estudantes, estejam esses sob situação virtual ou estado presencial. Ademais, o Comodale MultiMeios promoveu a continuidade das discussões após a finalização da aula síncrona, por intermédio de meios assíncronos, como o fórum, possibilitando uma avaliação contínua e paralela. Concluiu-se que este estudo contribui com novas abordagens no âmbito educacional, ampliando as possibilidades e promovendo uma educação compatível com o estado de coisas contemporâneo.

Palavras-chave: Ensino. Tecnologias. Comodale. Sequência Fedathi.
Contribuições e Limitadores no Uso de Metodologias Ativas no Ensino Semipresencial
Authors: Fietz Edina , Pereira Liandra , Kroenke Adriana , Hein Nelson 
Published: October 2024

O objetivo do presente estudo foi avaliar contribuições, limitadores e fatores geradores de interesse e engajamento dos acadêmicos e docentes nas metodologias ativas. Considerou-se a percepção dos acadêmicos dos cursos de graduação de uma universidade comunitária catarinense e para atendimento ao objetivo, utilizou-se a teoria do consenso e o fator de importância. A pesquisa foi conduzida mediante protocolo quantitativo, expressando a percepção de 155 acadêmicos, acerca do ensino semipresencial. No que tange aos resultados, ficou evidenciado que há equilíbrio e consenso moderado na maioria das variáveis estudadas, com destaque aos fatores de interesse e engajamento dos acadêmicos por aulas que envolvem metodologias ativas na modalidade semipresencial em que o consenso superou 60% nas alternativas avaliadas. Verifica-se também que a utilização dessas metodologias nas aulas promove o espírito investigativo e contribui para apropriação de conhecimentos, mas aponta a necessidade de maior participação por parte dos acadêmicos, o que requer uma mudança de postura. Ressalta-se também que a dificuldade dos acadêmicos perceberem a articulação entre a teoria e prática é um aspecto que precisa ser avaliado visto que é uma das propostas da adoção dessas metodologias, evidenciando que os acadêmicos têm suas expectativas centradas na relevância do papel do professor como gestor nesse processo.

Palavras-chave: Metodologias ativas. Teoria do consenso. Ensino semipresencial.
Philosophical Meaning in Dhawuhan Tradition in Warujanggan Village Magetan Regency
Authors: Mayastuti Ajeng Sekar , Saddhono Kundharu , Sulaksono Djoko 
Published: October 2024

Culture and tradition has become an inherent matter of society. Society acts as a subject that carries, shapes, changes, develops, and maintains the existence of culture and traditions. Strong ideology and meanings are important factors in the preservation of traditions from time to time. Philosophical meaning is one of the elements in a tradition so that society is able to maintain its existence. One of the traditions that still exists and develops especially in Javanese society and contains a very strong philosophical meaning is the village clean tradition. Javanese people, especially in Warujanggan Village, Magetan Regency, call this tradition a Dhawuhan tradition. This study used qualitative data that was analyzed descriptively. Some important things that will be conveyed in this study are certainly closely related to the Dhawuhan tradition itself and the philosophical meaning that contained in a series of Dhawuhan traditions. The Dhawuhan tradition carried out in Warujanggan village as a whole has 20 philosophical meanings which are divided into philosophical meanings in the procession or series of activities and offerings. Overall, the procession or series of Dhawuhan tradition activities carried out in Warujanggan village, Panekan District, Magetan Regency has a function as a form of honoring the ancestors and the procession of these traditional activities also shows modernization. In addition to the procession or series of activities, there are also offerings or offerings used during the Dhawuhan tradition held in Warujanggan village. There are so many kinds of offerings used. The offerings include: coffee, tea or water, market snacks, bananas or fruit, cigarettes, ambeng, tumpeng, sayur lodeh, serondeng, tempeh, coconut, fried noodles, cakes, peyek, and also crackers.
Effects of sediment on mechanical behavior of polypropylene fiber concrete before and after exposure to high temperature
Authors: Boulakoud Bilel 
Published: October 2024

The phenomenon of siltation of dams causes in Algeria a vital problem which annually loses a considerable volume of water storage.The objective of this study the valorization of calcined sediment from the Fergoug dam (western Algeria) in normal concrete exposed at 800 °C. Moreover, the sediments were calcination-treated at 750°C for 5 hours tomakeitactive. The different mixtures were prepared with 0%, 8%, 12% and 16% of sediment by partial substitution of cement , as well as of polypropylene fiber volume of 0.05% and 0.1%. All mixes were investigated on compressive strength and flexural strength at 90 days with different heating cooling cycles from the room temperature to 800 °C in electric muffle furnace. The experimental result indicates that the inclusion 8 and 12% of calcined sediment with fiber significantly enhances properties of normal concrete before and after heating, respectively.