bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weldability of 5754 aluminum alloy using a pulsed Nd:YAG micro scale laser
Authors: Köse Ceyhun 
Published: November 2016

Abstract
Use of laser welding is constantly increasing as it allows attainment of a high welding efficiency and weld quality. In this study, 5754 grade aluminum plates were joined on both sides by means of pulsed Nd:YAG power intensified micro scale laser welding method at three different laser powers in flat position by using supplemental welding wire. Mechanical properties of joints were examined by means of tensile and bending tests and by micro hardness measurements, and their structural changes were examined by means of optical microscope, SEM and EDS. As a result, it was determined that the welded joints could display an adequate tensile strength when exposed to tensile strain under action of static loads, but their bending strength remained relatively weaker. Mechanical properties of welded samples were observed to improve with increasing penetration depending on the increase in the laser power. It is believed that use of siliceous supplemental welding wire was also effective in strength improvement.
Enthalpies of mixing in binary liquid alloys of lutetium with 3d metals
Authors: Ivanov Michael , Berezutski Vadim , Usenko Natalia , Kotova Natalia 
Published: November 2016

AbstractThe enthalpies of mixing in binary liquid alloys of lutetium with chromium, cobalt, nickel and copper were determined at 1 773 – 1 947 K by isoperibolic calorimetry. The enthalpies of mixing in the Lu–Cr melts (measured up to 40 at.% Cr) demonstrate endothermic effects (ΔH = 6.88 ± 0.66 kJ · mol−1 at xLu = 0.60), whereas significant exothermic enthalpies of mixing have been established within a wide composition region for the Co–Lu, Ni–Lu and Cu–Lu liquid alloys. Minimum values of the integral enthalpy of mixing are as follows: ΔHmin = −23.57 ± 1.41 kJ · mol−1 at xLu = 0.38 for the Co–Lu system; ΔHmin = −48.65 ± 2.83 kJ · mol−1 at xLu = 0.40 for the Ni–Lu system; ΔHmin = −24.63 ± 1.52 kJ · mol−1 at xLu = 0.37 for the Cu–Lu system.
Sur une anomalie pigmentaire de la grenouille verte (Rana esculenta) et de quelques autres amphibiens Anoures et Urodèlespar
Authors: Dubois Alain , Vachard Daniel 
Published: November 2016

Résumé
L'anomalie N de la Grenouille verte (Rana esculenta ) est une anomalie pigmentaire qui se caractérise comme suit :
— chez l'imago à peine métamorphosé, l'iris de l'un ou des deux yeux est brun foncé, le dos noir-olivâtre, le ventre translucide ;
— par la suite, il peut y avoir soit retour rapide à une pigmentation totalement normale, sauf pour l'iris, soit conservation de la pigmentation anormale, avec apparition de diverses taches : taches blanchâtres, grisâtres ou noirâtres sur le ventre, taches dorées ou jaunes sur le dos.
L'étude de plusieurs de ces Grenouilles aux yeux noirs, ainsi que différents textes, plus ou moins récents, faisant mention de cette anomalie, permettent de formuler l'hypothèse selon laquelle celle-ci serait déterminée par des gènes multiples.
Des anomalies comparables ont déjà été décrites, ou sont décrites par nous, chez d'autres espèces d'Amphibiens Anoures et Urodèles. Les animaux atteints ont l'iris de l'un ou des deux yeux partiellement ou totalement noir ; la coloration du corps est normale dans certains cas, anormale dans d'autres.
Tant qu'elles ne sont pas mieux connues, nous proposons de regrouper ces anomalies pigmentaires sous le nom général d' «anomalie N ».
MIXING THE SOLAR WIND PROTON AND ELECTRON SCALES: EFFECTS OF ELECTRON TEMPERATURE ANISOTROPY ON THE OBLIQUE PROTON FIREHOSE INSTABILITY
Authors: Maneva Y. , Lazar M. , Viñas A. , Poedts S. 
Published: November 2016

ABSTRACT
The double adiabatic expansion of the nearly collisionless solar wind plasma creates conditions for the firehose instability to develop and efficiently prevent the further increase of the plasma temperature in the direction parallel to the interplanetary magnetic field. The conditions imposed by the firehose instability have been extensively studied using idealized approaches that ignore the mutual effects of electrons and protons. Recently, more realistic approaches have been proposed that take into account the interplay between electrons and protons, unveiling new regimes of the parallel oscillatory modes. However, for oblique wave propagation the instability develops distinct branches that grow much faster and may therefore be more efficient than the parallel firehose instability in constraining the temperature anisotropy of the plasma particles. This paper reports for the first time on the effects of electron plasma properties on the oblique proton firehose (PFH) instability and provides a comprehensive vision of the entire unstable wave-vector spectrum, unifying the proton and the smaller electron scales. The plasma β and temperature anisotropy regimes considered here are specific for the solar wind and magnetospheric conditions, and enable the electrons and protons to interact via the excited electromagnetic fluctuations. For the selected parameters, simultaneous electron and PFH instabilities can be observed with a dispersion spectrum of the electron firehose (EFH) extending toward the proton scales. Growth rates of the PFH instability are markedly boosted by the anisotropic electrons, especially in the oblique direction where the EFH growth rates are orders of magnitude higher.
THE ORIGIN OF DOUBLE-PEAKED NARROW LINES IN ACTIVE GALACTIC NUCLEI. II. KINEMATIC CLASSIFICATIONS FOR THE POPULATION AT z < 0.1
Authors: Nevin R. , Comerford J. , Müller-Sánchez F. , Barrows R. , Cooper M. 
Published: November 2016

ABSTRACT
We present optical long-slit observations of the complete sample of 71 Type 2 active galactic nuclei (AGNs) with double-peaked narrow emission lines at z < 0.1 in the Sloan Digital Sky Survey. Double-peaked emission lines are produced by a variety of mechanisms including disk rotation, kiloparsec-scale dual AGNs, and narrow-line region (NLR) kinematics (outflows or inflows). We develop a novel kinematic classification technique to determine the nature of these objects using long-slit spectroscopy alone. We determine that 86% of the double-peaked profiles are produced by moderate-luminosity AGN outflows, 6% are produced by rotation, and 8% are ambiguous. While we are unable to directly identify dual AGNs with long-slit data alone, we explore their potential kinematic classifications with this method. We also find a positive correlation between the NLR size and luminosity of the AGN NLRs (R

NLR

∝

L

[
O

III
]

0.21
±
0.05

), indicating a clumpy two-zone ionization model for the NLR.
DISTANCE-DEPENDENT OFFSETS BETWEEN PARALLAXES FOR NEARBY STARS AND GAIA DR1 PARALLAXES
Authors: Jao (饒惟君) Wei-Chun , Henry Todd J. , Riedel Adric R. , Winters Jennifer G. , Slatten Kenneth J. , Gies Douglas R. 
Published: November 2016

ABSTRACT
We use 612 single stars with previously published trigonometric parallaxes placing them within 25 pc to evaluate parallaxes released in Gaia’s first data release (DR1). We find that the Gaia parallaxes are, on average, 0.24 ± 0.02 mas smaller than the weighted mean trigonometric parallax values for these stars in the solar neighborhood. We also find that the offset changes with distance out to 100 pc, in the sense that the closer the star, the larger the offset. We find no systematic trends in the parallax offsets with stellar V magnitude, V − K color, or proper motion. We do find that the offset is roughly twice as large for stars south of the ecliptic compared to those that are north.
Two new records of palm species for Gabon: Sclerosperma profizianum Valk. &amp; Sunder. and Eremospatha quiquecostulata Becc.
Authors: Bourobou Bourobou Paul Henri , Niangadouma Raoul , Issembe Yves , Couvreur Thomas 
Published: November 2016

Gabon is an important center of biodiversity in Central Africa. The country contains to date 27 species of palms. However, palms are generally poorly collected as these massive plants are hard to press and curate. Thus, our understanding remains incomplete, especially in Central Africa.
We report three new records of two palm species for Gabon: Sclerosperma profizianum Valk. & Sunder. and Eremospatha quiquecostulata Becc.. The former species was collected in southeast Gabon, near Ndindi, while the later was collected in the Massif du Chaillu and Monts de Cristal National Park (Crystal Mountains National Park). The total number of palm species for Gabon is now 29, making it an important centre of palm diversity in Central Africa.
Le dévoilement du corps et le monde antérieur chez Jung et Pauli
Authors: Traversi Bruno 
Published: November 2016

La question du corps chez Carl Gustav Jung s’enracine dans sa théorie d’un « monde antérieur », dans lequel la sphère physique et la sphère psychique ne sont pas encore distinctes, et qui est au soubassement de la réalité telle qu’elle se donne à nous ordinairement – théorie qu’il façonne avec Wolfgang Pauli, l’un des pères de la mécanique quantique. Questionner le corps dans une perspective jungienne exige alors de comprendre le développement de ce plan fondamental en notre plan d’existence ordinaire où les sphères physique et psychique sont distinctes et s’opposent. L’accès à ce monde antérieur exige un enfouissement qui permet de mettre au jour des faits d’un nouveau genre pour lesquels les césures entre intériorité et extériorité, entre sujet et objet, ne sont plus valables. En alchimie et dans le yoga, cet enfouissement en soi se double de phénomènes d’extériorisations qui modifient le corps et son environnement. À l’occasion de ces extériorisations se révèle un corps originel capable de refléter et d’explorer les objets de la psyché.
Le mécanisme organique : À propos de la réception de Leibniz par Bourguet
Authors: Duchesneau François 
Published: November 2016

Correspondant de Leibniz, philosophe professant à Neuchâtel, Louis Bourguet (1678-1742) se fit l’interprète des vues de Leibniz sur le rapport entre monade et corps organique. Dans ses Lettres philosophiques (1729), il ne se contente pas d’analyser et de critiquer les diverses hypothèses relatives à la génération telles qu’on les soutenait à l’époque, mais il repense à nouveaux frais les arguments en faveur de la préformation et il réinsère la doctrine de l’« organisme » dans un cadre théorique inspiré de la monadologie. Il définit ainsi, sous le vocable de « mécanisme organique », des principes aptes à régir les recherches de philo­sophie expérimentale sur le vivant. Il adapte de diverses façons les thèses leibniziennes et ouvre ainsi la voie à des évolutions marquantes du concept de corps organique au xviii	e	siècle.
Dynamica abstracta et dynamica concreta
Authors: Costa Andrea 
Published: November 2016

La bipartition entre une dynamica abstracta et une dynamica concreta est récurrente dans la production scientifique leibnizienne en dépit des acquisitions conceptuelles qui – dès la rédaction de la Dynamica de Potentia de 1690 – permettraient de la dépasser. S’appuyant sur l’étude des manuscrits inédits réalisée en vue de la publication de la première édition critique du traité, l’article se propose : 1. d’explorer les raisons de la permanence d’une telle structure à la lumière des travaux logiques et grammaticaux leibniziens sur l’abstrait et le concret – 2. d’offrir au lecteur une contextualisation et une présentation générale de l’œuvre, ainsi qu’un aperçu du nouveau matériau éditorial disponible.
Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3
Authors: Takacs Erika , Boto Pal , Simo Emilia , Csuth Tamas I. , Toth Bianka M. , Raveh-Amit Hadas , Pap Attila , Kovács Elek G. , Kobolak Julianna , Benkö Szilvia , Dinnyes Andras , Szatmari Istvan 
Published: November 2016

Abstract
Application of dendritic cells (DCs) to prime responses to tumor Ags provides a promising approach to immunotherapy. However, only a limited number of DCs can be manufactured from adult precursors. In contrast, pluripotent embryonic stem (ES) cells represent an inexhaustible source for DC production, although it remains a major challenge to steer directional differentiation because ES cell–derived cells are typically immature with impaired functional capacity. Consistent with this notion, we found that mouse ES cell–derived DCs (ES-DCs) represented less mature cells compared with bone marrow–derived DCs. This finding prompted us to compare the gene expression profile of the ES cell– and adult progenitor-derived, GM-CSF–instructed, nonconventional DC subsets. We quantified the mRNA level of 17 DC-specific transcription factors and observed that 3 transcriptional regulators (Irf4, Spi-B, and Runx3) showed lower expression in ES-DCs than in bone marrow–derived DCs. In light of this altered gene expression, we probed the effects of these transcription factors in developing mouse ES-DCs with an isogenic expression screen. Our analysis revealed that forced expression of Irf4 repressed ES-DC development, whereas, in contrast, Runx3 improved the ES-DC maturation capacity. Moreover, LPS-treated and Runx3-activated ES-DCs exhibited enhanced T cell activation and migratory potential. In summary, we found that ex vivo–generated ES-DCs had a compromised maturation ability and immunogenicity. However, ectopic expression of Runx3 enhances cytokine-driven ES-DC development and acts as an instructive tool for the generation of mature DCs with enhanced immunogenicity from pluripotent stem cells.
Soluble TNF Regulates TACE via AP-2α Transcription Factor in Mouse Dendritic Cells
Authors: Ge Lisheng , Vujanovic Nikola L. 
Published: November 2016

Abstract
Dendritic cells (DCs), the essential immunoregulatory and APCs, are major producers of the central mediator of inflammation, soluble TNF-α (sTNF). sTNF is generated by TNF-α converting enzyme (TACE) proteolytic release of the transmembrane TNF (tmTNF) ectodomain. The mechanisms of TACE and sTNF regulation in DCs remain elusive. This study newly defines that sTNF regulates TACE in mouse DCs by engaging the AP-2α transcription factor. We found that the expression of AP-2α was higher, whereas the expression and activity of TACE were lower, in wild-type DCs (wtDCs) than in TNF knockout (TNFko) DCs. Exogenous sTNF rapidly and simultaneously induced increases of AP-2α expression and decreases of TACE expression and activity in wtDCs and TNFko DCs, indicating that AP-2α and TACE are inversely dependent on sTNF and are functionally associated. To define this functional association, we identified an AP-2α binding site in TACE promoter and demonstrated, using EMSAs and chromatin immunoprecipitation assays, that AP-2α could bind to TACE promoter in a TNF-dependent manner. Additionally, sTNF simultaneously enhanced AP-2α expression and decreased TACE promoter luciferase activity in DCs. Similarly, transfection of AP-2α cDNA decreased TACE promoter luciferase activity, TACE expression, and TACE enzymatic activity in wtDCs or TNFko DCs. In contrast, transfection of AP-2α small interfering RNA increased TACE promoter luciferase activity, TACE expression, and TACE enzymatic activity in wtDCs. These results show that TACE is a target of, and is downregulated by, sTNF-induced AP-2α transcription factor in DCs.
Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire
Authors: Li Kun-Po , Fähnrich Anke , Roy Eron , Cuda Carla M. , Grimes H. Leighton , Perlman Harris R. , Kalies Kathrin , Hildeman David A. 
Published: November 2016

Abstract
CD8αα TCRαβ+ intestinal intraepithelial lymphocytes play a critical role in promoting intestinal homeostasis, although mechanisms controlling their development and peripheral homeostasis remain unclear. In this study, we examined the spatiotemporal role of Bim in the thymic selection of CD8αα precursors and the fate of these cells in the periphery. We found that T cell–specific expression of Bim during early/cortical, but not late/medullary, thymic development controls the agonist selection of CD8αα precursors and limits their private TCRβ repertoire. During this process, agonist-selected double-positive cells lose CD4/8 coreceptor expression and masquerade as double-negative (DN) TCRαβhi thymocytes. Although these DN thymocytes fail to re-express coreceptors after OP9-DL1 culture, they eventually mature and accumulate in the spleen where TCR and IL-15/STAT5 signaling promotes their conversion to CD8αα cells and their expression of gut-homing receptors. Adoptive transfer of splenic DN cells gives rise to CD8αα cells in the gut, establishing their precursor relationship in vivo. Interestingly, Bim does not restrict the IL-15–driven maturation of CD8αα cells that is critical for intestinal homeostasis. Thus, we found a temporal and tissue-specific role for Bim in limiting thymic agonist selection of CD8αα precursors and their TCRβ repertoire, but not in the maintenance of CD8αα intraepithelial lymphocytes in the intestine.
Sensitivity to Restimulation-Induced Cell Death Is Linked to Glycolytic Metabolism in Human T Cells
Authors: Larsen Sasha E. , Bilenkin Abegail , Tarasenko Tatiana N. , Arjunaraja Swadhinya , Stinson Jeffrey R. , McGuire Peter J. , Snow Andrew L. 
Published: November 2016

Abstract
Restimulation-induced cell death (RICD) regulates immune responses by restraining effector T cell expansion and limiting nonspecific damage to the host. RICD is triggered by re-engagement of the TCR on a cycling effector T cell, resulting in apoptosis. It remains unclear how RICD sensitivity is calibrated in T cells derived from different individuals or subsets. In this study we show that aerobic glycolysis strongly correlates with RICD sensitivity in human CD8+ effector T cells. Reducing glycolytic activity or glucose availability rendered effector T cells significantly less sensitive to RICD. We found that active glycolysis specifically facilitates the induction of proapoptotic Fas ligand upon TCR restimulation, accounting for enhanced RICD sensitivity in highly glycolytic T cells. Collectively, these data indicate that RICD susceptibility is linked to metabolic reprogramming, and that switching back to metabolic quiescence may help shield T cells from RICD as they transition into the memory pool.
An Ulm-like Cayley Transform Method for Inverse Eigenvalue Problems with Multiple Eigenvalues
Authors: Shen Weiping , Li Chong , Jin Xiaoqing 
Published: November 2016

AbstractWe study the convergence of an Ulm-like Cayley transform method for solving inverse eigenvalue problems which avoids solving approximate Jacobian equations. Under the nonsingularity assumption of the relative generalized Jacobian matrices at the solution, a convergence analysis covering both the distinct and multiple eigenvalues cases is provided and the quadratical convergence is proved. Moreover, numerical experiments are given in the last section to illustrate our results.
Immunotherapeutic efficacy of a Lactobacillus casei lysate as an adjuvant combined with a heated-4T1 mammary carcinoma cell lysate in a murine model of breast cancer
Authors: Dorostkar Ruhollah , Hashemzadeh Mohammad Sadegh , Jafari Sajjad , Tat Mahdi , Ghalavand Majdedin , Asghari Mohammad Hossein , Moloudizargari Milad 
Published: November 2016

Abstract

Background
Immunotherapy, during which the immune system of the patient is manipulated to act against tumors has been among the most successful methods in the treatment of breast cancer, a leading cause of mortality among women worldwide.

Objectives
To investigate the immunotherapeutic efficacy of Lactobacillus casei lysate as an adjuvant in combination with a heated-4T1 mammary carcinoma cell lysate in a model of breast cancer.

Methods
After ethics committee approval of all animal procedures, a murine model of breast cancer was induced in BALB/c mice using 4T1 cells. These mice were immunized with a combination of lysates of heated 4T1 cells and L. casei. Subsequent changes in tumor size and weight, and the production of TNF-α, IL-2, IL-12, IL-17, and IL13 were measured. Lung weights were measured as an indicator of metastasis to other organs.

Results
The tumor size and weight in mice immunized with the combined vaccine were significantly reduced compared with controls. The combined immunotherapy altered the pattern of cytokine production to the advantage of antitumor immunity, and was significantly more potent than immunization with heated-4T1-cell lysate or L. casei lysate alone.

Conclusions
Coadministration of L. casei lysate enhanced the immunotherapeutic efficacy of the heated-4T1-cell lysate as a source of tumor-associated antigens. L. casei can potentially be used as an adjuvant combined with sources of tumor antigens in the treatment of cancers, and as a safe alternative to the current adjuvants that cause greater irritation to hosts. Further studies are required to clarify the mechanisms underlying these effects.
Correlation of computed tomography characteristics of cystic renal cell carcinoma with histopathology
Authors: Burapasomboon Pattarin , Boonsirikamchai Piyaporn , Sasiwimonphan Kewalee 
Published: November 2016

Abstract

Background
Renal cysts are common incidental findings in computed tomography (CT) of the abdomen and range from benign to cystic renal cell carcinoma (RCC). Cystic RCC has various pathology, clinical prognosis, and treatment options.

Objectives
To compare preoperative CT of cystic RCC with histopathology.

Methods
Preoperative CT of histopathologically proven cystic RCCs were retrospectively reviewed in this single-center cross-sectional observational study. Two investigators recorded consensus CT features for each cystic RCC. The means of descriptive continuous data were calculated. A chi-square test, Fisher’s exact test, or an ANOVA were used for compare the frequency of findings for each histopathological subtype.

Results
Of 38 cystic RCCs, 25 were clear cell RCC, 5 were papillary RCC, 4 were multilocular cystic RCC, 1 was chromophobe RCC, and 3 were mixed type/other type (papillary/chromophobe, clear cell/chromophobe, and sarcomatoid type). We classified 36 lesions as Bosniak category IV and 2 lesions as Bosniak category III. There was no significant difference in cyst attenuation in any phase. Solid attenuation of the tumors was significantly different for each type in corticomedullary and nephrogenic phases (P = 0.001 and 0.042, respectively). Clear cell RCC was enhanced the most on corticomedullary and nephrogenic phases (means 135.5 and 112.1 Hounsfield Units, respectively). Septal thickening, enhancement, and multilocularity were significantly different between subtypes, particularly in multilocular cystic RCCs (P = 0.018, 0.018, and 0.02, respectively).

Conclusion
Preoperative CT findings may help clinicians and radiologists to predict tumor subtypes and aid treatment planning.