bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: REDUCTION‐OXIDATION PROPERTIES OF ORGANOTRANSITION METAL COMPLEXES. PART 16. NITROSYL‐BRIDGED DICOBALT COMPLEXES ((CO(μ‐NO)(η‐C5R5))2)Z (R = H OR ME, Z = 0 TO +2) AND (CO2(μ‐CO)(μ‐NO)(η‐C5ME5)2)Z (Z = 0 OR +1): SYNTHESIS, ELECTROCHEMISTRY, AND RELATIVE REACTIVITY
Authors: CONNELLY N. G. , PAYNE J. D. , GEIGER W. E. 
Published: May 2016

AbstractWährend die Reaktion von (I) mit NO[PF6] in CH,Cl, bei Raumtemp. zu verschiedenen kationischen Carbonylnitrosylkomplexen führt, reagieren äquimolare Mengen der Verbindungen in CH2Cl, bei Rückflußtemp.
ChemInform Abstract: PREPARATION, STRUCTURE, AND REACTIONS OF ALKENYL COMPLEXES OF RUTHENIUM(II)
Authors: HOLLAND P. R. , HOWARD B. , MAWBY R. J. 
Published: May 2016

AbstractDie trans‐Komplexe (I) reagieren mit den Alkinen (II) unter Bildung der Titelkomplexe (III).
ChemInform Abstract: THE SYNTHESIS OF (RU5C(CO)15) BY THE CARBONYLATION OF (RU6C(CO)17) AND THE REACTIONS OF THE PENTANUCLEAR CLUSTER WITH A VARIETY OF SMALL MOLECULES: THE X‐RAY CRYSTAL ANALYSES OF (RU5C(CO)15), (RU5C(CO)15(MECN)), (RU5C(CO)14(PPH3)), (RU5C(CO)13(PPH3)2), AND (RU5(μ‐H)2C(CO)12(PH2P(CH2)2PPH2))
Authors: JOHNSON B. F. G. , LEWIS J. , NICHOLLS J. N. , PUGA J. , RAITHBY P. R. , ROSALES M. J. , MCPARTLIN M. , CLEGG W. 
Published: May 2016

AbstractDer Hexarutheniumcluster (I) liefert durch Carbonylierung den fünfkernigen Cluster (II), der in der RG P21/c mit Z=8 kristallisiert.
ChemInform Abstract: PHOTOCHEMISTRY OF RUTHENIUM CLUSTER CARBONYLS SUPPORTED ON SILICA SURFACE. ISOLATION OF COORDINATIVELY UNSATURATED SPECIES
Authors: DOI Y. , YANO K. 
Published: May 2016

AbstractDie Photolyse der an SiO2 angelager ten Cluster Ru3(CO)" und H4Ru4(CO)" bei Raumtemp. unter N2 oder H2 wird mittels IR‐ und UV/VIS‐Spektroskopie untersucht.
ChemInform Abstract: NEW CARBIDE CLUSTERS IN THE COBALT SUB‐GROUP. PART 10. PREPARATION AND CRYSTALLOGRAPHIC CHARACTERIZATION OF DICARBIDOOCTA‐μ‐CARBONYLHEXADECARBONYL‐POLYHEDRO‐DODECARHODATE(2‐) AS ITS BIS(TRIPHENYLPHOSPHINE)IMINIUM SALT, (N(PPH3)2)2(RH12C2(CO)24)
Authors: ALBANO V. G. , BRAGA D. , CHINI P. , STRUMOLO D. , MARTINENGO S. 
Published: May 2016

AbstractNew Carbide Clusters in the Cobalt Sub‐group.
ChemInform Abstract: 2,2′‐BIBENZIMIDAZOLATE ANIONS AS BRIDGING LIGANDS IN CATIONIC HETERONUCLEAR GOLD(I)‐RHODIUM(I) COMPLEXES. CRYSTAL STRUCTURE OF (1,1′‐BIS(TRIPHENYLPHOSPHINEAURIO)‐2,2′‐DIBENZIMIDAZOLE‐N3,N3′)(η‐CYCLOOCTA# ‐1,5‐DIENE)RHODIUM PERCHLORATE‐CHLOROFORM (1/1)
Authors: USON R. , ORO L. A. , GIMENO J. , CIRIANO M. A. , CABEZA J. A. , TIRIPICCHIO A. , TIRIPICCHIO CAMELLINI M. 
Published: May 2016

AbstractDie 2,2′‐Bibenzimidazolato‐diolefin‐Rh(I)‐Komplexe (II), Produkte aus entsprechenden Acetylacetonat‐Analogen und 2,2′‐Bibenzimidazol, in denen die Diolefine substituierbar unter Bildung der Derivate (I) sind, bilden bei Umsetzung mit AgClO4/ AuClL3 die kationischen Heterometall‐Komplexe (IIIa).
ChemInform Abstract: PALLADIUM CATALYZED CLEAVAGE OF PHENYL‐ANTIMONY GROUPS OF TRIPHENYLSTIBINE
Authors: GOEL A. B. , RICHARDS H. J. , KYUNG J. H. 
Published: May 2016

AbstractUntersuchungen zeigen, daß eine Sb‐C‐Bindung in Triphenylstibin beim Erhitzen in Toluol in Gegenwart von Pd(II)‐acetat oder ‐chlorid ‐ selbst in katalytischen Men‐ gen ‐ vermutlich über Komplexierung am Pd‐lon gespalten wird.
ChemInform Abstract: ELECTROPHILIC SUBSTITUTION REACTIONS OF DERIVATIVES OF DEUTEROPORPHYRIN‐IX: DEUTERIATION AND VILSMEIER FORMYLATION
Authors: SMITH K. M. , LANGRY K. C. 
Published: May 2016

AbstractDie Methylester von Deuteroporphyrin‐IX (Ia), Protoporphyrin‐IX (Ib), 2,4‐Diacetyl‐deuteroporphyrin‐IX (Ic) und Mesoporphyrin‐ IX (Id) werden beim Behandeln mit [2H]‐p‐Toluolsulfonsäure/D2O ( in o‐Dichlorbenzol, 95°C) an allen vier meso‐Positionen deuteriert (Produkt‐Ausb. 68‐94%).
ChemInform Abstract: ARYLAZOGLYCENOSIDES. PART 8. SYNTHESIS AND REACTIONS OF SOME 2‐ AND 3‐ARYLAZO O DERIVATIVES OF METHYL 4,6‐O‐BENZYLIDENE‐2,3‐DIDEOXY‐D‐THREO‐HEX‐2‐ENOPYRANOSIDES
Authors: DANG N. , MUNASINGHE V. R. N. , OVEREND W. G. 
Published: May 2016

AbstractBei der Benzoylierung des Galactosederivats (Ia) werden die Produkte (Ib) + (Ic) gebildet; (Ib) wird über das Oxidationsprodukt (IIa) und dessen Phenylhydrazon (IIb) zum Phenylazo‐hexenopyranosid (IIIa) umgesetzt; das Isomere (IIIb) wird ähnlich ausgehend von (Ic) erhalten.
ChemInform Abstract: A STEREOSELECTIVE TOTAL SYNTHESIS OF EPI‐LUPININE
Authors: BREMMER M. L. , WEINREB S. M. 
Published: May 2016

AbstractMethylsorbat (I) wird über das Anion mit dem Brompropionaldehydacetal (II) zu (III) substituiert und über eine Umlagerung in das Dien (IV) übergeführt.
ChemInform Abstract: A NEW TYPE OF PROTECTION MODE FOR THE GUANINE RESIDUE USING THE 1,2‐DIISOBUTYRYLOXYETHYLENE GROUP
Authors: SEKINE M. , MATSUZAKI J. , HATA T. 
Published: May 2016

AbstractEs wird die Verwendung der 1,2‐Diisobutyryloxyethylen‐ Gruppe als Schutzgruppe für den Guaninrest bei der Synthese entsprechender Oligonucleotide beschrieben.
ChemInform Abstract: NUCLEOTIDE CHEMISTRY. X. AN INVESTIGATION OF SEVERAL DEOXYNUCLEOSIDE PHOSPHORAMIDITES USEFUL FOR SYNTHESIZING DEOXYOLIGONUCLEOTIDES
Authors: MCBRIDE L. J. , CARUTHERS M. H. 
Published: May 2016

AbstractDichlormethoxy‐phosphor (I) liefert die Monoamide (II), die mit Verbindungen wie (III) zu Nucleosidphosphoramiditen (IV) kondensiert werden können.
ChemInform Abstract: NATURALLY OCCURRING DIBENZOFURANS. PART 3. ON THE STRUCTURES OF THE RHODOMYRTOXINS
Authors: SARGENT M. V. , STRANSKY P. O. , PATRICK V. A. , WHITE A. H. 
Published: May 2016

AbstractDie Synthese aus dem Biphenylderivat (I) bzw. dem Diol (IV) und anschließende Untersuchungen beweisen, daß es sich bei dem Abbauprodukt von Rhodomyrtoxin und w‐Rhodomyrtoxin (Metaboliten der Frucht von Rhodomyrtus macrocarpa Benth.) um die Verbindung mit der Struktur (III) handelt [RG: P1 (Cf , No.
ChemInform Abstract: SCENSIDIN, A NEW DEPSIDONE FROM THE LICHEN BUELLIA CANESCENS (DICKS.) DE NOT
Authors: MAHANDRU M. M. , TAJBAKHSH A. 
Published: May 2016

AbstractDie biogenetisch favorisierte Struktur (VI) der Titelverbindung wird durch ihre Synthese aus der Säure (I) und dem Toluolderivat (II) über das Keton (III) und die Stufen (IV), (V) oder (IV) , (VII) bestätigt.
ChemInform Abstract: NATURAL BENZOFURANS. SYNTHESIS OF EUPOMATENOIDS‐1, ‐3, ‐4, ‐5, ‐6, ‐7, AND ‐13
Authors: MCKITTRICK B. A. , STEVENSON R. 
Published: May 2016

AbstractDie Darstellungen der Titelverbindungen, Eupomatenoid‐3 (VIIIa) und ‐4 (VIIIb), Eupomatenoid‐5 (XIIIb) und ‐6 (XIIIa), Eupomatenoid‐1 (XVIIIa) und Eupomatenoid‐7 (XIXa) und ‐13 (XIXb) werden beschrieben.
ChemInform Abstract: PROSTAGLANDINS. PART 7. SYNTHESIS OF (.+‐.)‐11‐DEOXY‐10‐HYDROXY‐ AND (.+‐.)‐11‐DEOXY‐10‐OXOPROSTAGLANDINS
Authors: CATON M. P. L. , DARNBROUGH G. , PARKER T. , PEART B. J. , PODMORE M. L. , THRELFALL T. L. 
Published: May 2016

AbstractDas aus der Säure (I) zugängliche Derivat (IId) läßt sich mit den Iodiden (III) bzw. (VI) zu den Titelverbindungen (IV) [‐ Autoxidation von (IVa) zu der entsprechenden Oxoverbindung (V)] bzw. (VII) umsetzen.
ChemInform Abstract: SYNTHESIS OF A NOVEL C‐6 NITROGEN‐SUBSTITUTED CARBAPENEM FROM 6‐AMINOPENICILLANIC ACID
Authors: YAMAMOTO K. , NISHINO M. , KATO Y. , YOSHIOKA T. , SHIMAUCHI Y. , ISHIKURA T. 
Published: May 2016

Abstract′"2, Synthesis of a Novel C‐6 Nitrogen‐substituted Carbapenem from 6‐Aminopenicillanic Acid.
ChemInform Abstract: CONTAMINATION‐FREE HIGH TEMPERATURE TREATMENT OF SILICON OR OTHER MATERIALS
Authors: SCHMIDT P. F. 
Published: May 2016

AbstractBei der Hochtemp.‐Behandlung in Quarz‐Röhren erfolgt Diffusion von Verunreinigungselementen in die Röhren entlang Korngrenzen im glasigen Quarz.
Isoxazole‐Based‐Scaffold Inhibitors Targeting Cyclooxygenases (COXs)
Authors: Perrone Maria Grazia , Vitale Paola , Panella Andrea , Ferorelli Savina , Contino Marialessandra , Lavecchia Antonio , Scilimati Antonio 
Published: May 2016

AbstractA new set of cyclooxygenase (COX) inhibitors endowed with an additional functionality was explored. These new compounds also contained either rhodamine 6G or 6,7‐dimethoxy‐1,2,3,4‐tetrahydroisoquinoline, two moieties typical of efflux pump substrates and inhibitors, respectively. Among all the synthesized compounds, two new COX inhibitors with opposite selectivity were discovered: compound 8 [N‐(9‐{2‐[(4‐{2‐[3‐(5‐chlorofuran‐2‐yl)‐4‐phenylisoxazol‐5‐yl]acetamido}butyl)carbamoyl]phenyl‐6‐(ethylamino)‐2,7‐dimethyl‐3H‐xanthen‐3‐ylidene}ethanaminium chloride] was found to be a selective COX‐1 inhibitor, whereas 17 (2‐[3,4‐bis(4‐methoxyphenyl)isoxazol‐5‐yl]‐1‐[6,7‐dimethoxy‐3,4‐dihydroisoquinolin‐2‐(1H)‐yl]ethanone) was found to be a sub‐micromolar selective COX‐2 inhibitor. However, both were shown to interact with P‐glycoprotein. Docking experiments helped to clarify the molecular aspects of the observed COX selectivity.
Molecular Basis of the Receptor Interactions of Polysialic Acid (polySia), polySia Mimetics, and Sulfated Polysaccharides
Authors: Zhang Ruiyan , Loers Gabriele , Schachner Melitta , Boelens Rolf , Wienk Hans , Siebert Simone , Eckert Thomas , Kraan Stefan , Rojas‐Macias Miguel A. , Lütteke Thomas , Galuska Sebastian P. , Scheidig Axel , Petridis Athanasios K. , Liang Songping , Billeter Martin , Schauer Roland , Steinmeyer Jürgen , Schröder Jens‐Michael , Siebert Hans‐Christian 
Published: May 2016

AbstractPolysialic acid (polySia) and polySia glycomimetic molecules support nerve cell regeneration, differentiation, and neuronal plasticity. With a combination of biophysical and biochemical methods, as well as data mining and molecular modeling techniques, it is possible to correlate specific ligand–receptor interactions with biochemical processes and in vivo studies that focus on the potential therapeutic impact of polySia, polySia glycomimetics, and sulfated polysaccharides in neuronal diseases. With this strategy, the receptor interactions of polySia and polySia mimetics can be understood on a submolecular level. As the HNK‐1 glycan also enhances neuronal functions, we tested whether similar sulfated oligo‐ and polysaccharides from seaweed could be suitable, in addition to polySia, for finding potential new routes into patient care focusing on an improved cure for various neuronal diseases. The knowledge obtained here on the structural interplay between polySia or sulfated polysaccharides and their receptors can be exploited to develop new drugs and application routes for the treatment of neurological diseases and dysfunctions.
Copula‐based joint probability function for PGA and CAV: a case study from Taiwan
Authors: Xu Yun , Tang Xiao‐Song , Wang J. P. , Kuo‐Chen H. 
Published: May 2016

SummaryThis study aims to develop a joint probability function of peak ground acceleration (PGA) and cumulative absolute velocity (CAV) for the strong ground motion data from Taiwan. First, a total of 40,385 earthquake time histories are collected from the Taiwan Strong Motion Instrumentation Program. Then, the copula approach is introduced and applied to model the joint probability distribution of PGA and CAV. Finally, the correlation results using the PGA‐CAV empirical data and the normalized residuals are compared. The results indicate that there exists a strong positive correlation between PGA and CAV. For both the PGA and CAV empirical data and the normalized residuals, the multivariate lognormal distribution composed of two lognormal marginal distributions and the Gaussian copula provides adequate characterization of the PGA‐CAV joint distribution observed in Taiwan. This finding demonstrates the validity of the conventional two‐step approach for developing empirical ground motion prediction equations (GMPEs) of multiple ground motion parameters from the copula viewpoint. Copyright © 2016 John Wiley & Sons, Ltd.
A comparison of biohydrodynamic interaction within mangrove and saltmarsh boundaries
Authors: Chen Yining , Li Yan , Cai Tinglu , Thompson Charlotte , Li Yi 
Published: May 2016

AbstractMangrove forests and saltmarshes are recognized for their roles in wave and current attenuation, although a comparison of in situ observations between woody and herbaceous plants is needed in order to understand the different mechanisms of bio‐physical interaction within coastal wetlands. The aim of our study was to compare the mechanisms of flow reduction and energy dissipation by mangrove trees and saltmarsh grass in a subtropical area where tidal currents dominate. Fieldwork was conducted to measure the hydrodynamic processes occurring at the boundaries between a bare mudflat and vegetated tidal flat, as the flow transitions from a bare mudflat to either mangrove or saltmarsh. Synchronous acoustic Doppler velocimetry (ADV) measurements at three sites revealed that the mangrove was more effective than the saltmarsh grass at flow reduction. In addition, a considerable rotation in flow direction was observed as the flow entered the mangrove trees, while rotation was considerably less pronounced within the saltmarsh edge. The mechanism for this difference was explained through a combination of changes in drag force and eddy viscosity over the two vegetation types. Although overall the mangrove was observed to dissipate energy more effectively than the saltmarsh, the relative efficiency of the vegetation at dissipating turbulent energy was found to vary with the maximum water level of tidal cycle. When the maximum water level remained below the mangrove canopy bottom (‘bio‐line’), the energy dissipation ability of the mangrove was relatively low, as a result of the presence of rigid, sparse trunks rather than denser saltmarsh grass found near the bed; when the maximum water level was sufficiently high to reach the mangrove canopy, the ability of the mangrove to dissipate energy was significantly increased, becoming more effective than the saltmarsh grass. Copyright © 2016 John Wiley & Sons, Ltd.
On the morphological characteristics of overdeepenings in high‐mountain glacier beds
Authors: Haeberli Wilfried , Linsbauer Andreas , Cochachin Alejo , Salazar Cesar , Fischer Urs H. 
Published: May 2016

AbstractOverdeepenings, i.e. closed topographic depressions with adverse slopes in the direction of flow, are characteristic for glacier beds and glacially sculpted landscapes. Quantitative information about their morphological characteristics, however, has so far hardly been available. The present study provides such information by combining the analysis of (a) numerous bed overdeepenings below still existing glaciers of the Swiss Alps and the Himalaya‐Karakoram region modelled with a robust shear stress approximation and (b) detailed bathymetries from recently exposed lakes in the Peruvian Andes. The investigated overdeepenings exist where glacier surface slopes are low (< 5°–10°), occur in bedrock or morainic material and are most commonly a fraction of a kilometre squared in surface area, hundreds of metres long, about half the length in width and tens of metres deep. They form under conditions of low to high basal shear stresses, at cirque, confluence, trunk valley and terminus positions. The most striking phenomenon, however, is the high variability of their geometries: Depths, surface areas, lengths and widths of the overdeepenings vary over orders of magnitude and are only weakly – if at all – interrelated. Inclinations of adverse slopes do not differ significantly from those of forward slopes and are in many cases higher than so far assumed theoretical limits for supercooling of ascending water and corresponding closure of sub‐glacial channels. Such steep adverse slopes are a robust observation and in support of recently developed new concepts concerning the question about where supercooling of sub‐glacial water and closure of ice channels can or must occur. However, the question of when and under what climatic, topographic and ice conditions the overdeepenings had formed remains unanswered. This open question constitutes a key problem concerning the interpretation of observed overdeepenings, the understanding of the involved glacio‐hydraulic processes and the possibility of realistic predictive modelling of overdeepening formation. Copyright © 2016 John Wiley & Sons, Ltd.
Functional organization of the fusiform gyrus revealed with connectivity profiles
Authors: Zhang Wen , Wang Jiaojian , Fan Lingzhong , Zhang Yuanchao , Fox Peter T. , Eickhoff Simon B. , Yu Chunshui , Jiang Tianzi 
Published: May 2016

AbstractWithin the object recognition‐related ventral visual stream, the human fusiform gyrus (FG), which topographically connects the striate cortex to the inferior temporal lobe, plays a pivotal role in high‐level visual/cognitive functions. However, though there are many previous investigations of distinct functional modules within the FG, the functional organization of the whole FG in its full functional heterogeneity has not yet been established. In the current study, a replicable functional organization of the FG based on distinct anatomical connectivity patterns was identified. The FG was parcellated into medial (FGm), lateral (FGl), and anterior (FGa) regions using diffusion tensor imaging. We validated the reasonability of such an organizational scheme from the perspective of resting‐state whole brain functional connectivity patterns and the involvement of functional subnetworks. We found corroborating support for these three distinct modules, and suggest that the FGm serves as a transition region that combines multiple stimuli, the FGl is responsible for categorical recognition, and the FGa is involved in semantic understanding. These findings support two organizational functional transitions of the ventral temporal gyrus, a posterior/anterior direction of visual/semantic processing, and a media/lateral direction of high‐level visual processing. Our results may facilitate a more detailed study of the human FG in the future. Hum Brain Mapp 37:3003–3016, 2016. © 2016 Wiley Periodicals, Inc.
Feasibility of photoacoustic evaluations on dual‐thermal treatment of ex vivo bladder tumors
Authors: Nguyen Van Phuc , Oh Junghwan , Park Suhyun , Wook Kang Hyun 
Published: May 2016

A variety of thermal therapeutic methods have been investigated to treat bladder tumors but often cause bowel injury and bladder wall perforation due to high treatment dosage and limited clinical margins. The objective of the current study is to develop a dual‐thermal modality to deeply coagulate the bladder tumors at low thermal dosage and to evaluate therapeutic outcomes with high contrast photoacoustic imaging (PAI). High intensity focused ultrasound (HIFU) is combined with 532 nm laser light to enhance therapeutic depth during thermal treatments on artificial tumor‐injected bladder tissue ex vivo. PAI is employed to identify the margins of the tumors pre‐ and post‐treatments. The dual‐thermal modality achieves 3‐ and 1.8‐fold higher transient temperature changes and 2.2‐ and 1.5‐fold deeper tissue denaturation than laser and HIFU, respectively. PAI vividly identifies the position of the injected tumor and entails approximately 7.9 times higher image contrast from the coagulated tumor as that from the untreated tumor. Spectroscopic analysis exhibits that both 740 nm and 760 nm attains the maximum photoacoustic amplitudes from the treated areas. The proposed PAI‐guided dual‐thermal treatments (laser and HIFU) treatments can be a feasible therapeutic modality to treat bladder tumors in a controlled and efficient manner.
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High‐resolution scanning XRF investigation of Chinese loess and its implications for millennial‐scale monsoon variability
Authors: Sun Youbin , Liang Lianji , Bloemendal Jan , Li Ying , Wu Feng , Yao Zhengquan , Liu Yanguang 
Published: May 2016

ABSTRACTMillennial‐scale monsoon variability has been investigated intensively using loess‐based proxies; however, the amplitude and rhythms of millennial‐scale signals have seldom been disentangled from the background glacial–interglacial changes. Here we present the results of high‐resolution scanning X‐ray fluorescence analysis of a 75‐m‐thick loess sequence from the north‐western Chinese Loess Plateau to address glacial–interglacial to millennial monsoon variability over the last two climatic cycles. Variations of the Si/K, Fe/K and Ca/K ratios are separated spectrally into low‐ and high‐frequency components corresponding to glacial–interglacial and millennial‐scale monsoon variability, respectively. The results indicate that the three elemental ratios exhibit similar glacial–interglacial variability but with varying spectral densities at the 100‐, 41‐ and 23‐kyr periodicities. Millennial‐scale variability is quite similar between the three elemental ratios, and comparable to those inferred from records of Chinese speleothem δ18O, Greenland palaeotemperature and North Atlantic cooling events. Comparison of various proxies indicates the broad similar magnitudes of abrupt climate changes, at least during the last two glacial–interglacial cycles, whereas the timing and amplitude of abrupt climatic events are not well correlated. We suggest that refinement of loess chronology and intensive data‐model integration in the future are critical to decipher the characteristics and dynamics of rapid monsoon changes.
Phenotypic characterization and clinical outcome in ampullary adenocarcinoma
Authors: Asano Eisuke , Okano Keiichi , Oshima Minoru , Kagawa Seiko , Kushida Yoshio , Munekage Masaya , Hanazaki Kazuhiro , Watanabe Jota , Takada Yasutsugu , Ikemoto Tetsuya , Shimada Mitsuo , Suzuki Yasuyuki ,   On behalf of the Shikoku Consortium of Surgical Research (SCSR)
Published: May 2016

BackgroundAlthough various features of ampullary adenocarcinoma have been reported, the impact of genetic alterations and rare subtypes on clinical outcome remains unclear.MethodsWe determined the expression of proteins, including MUC1, MUC2, p53, p16, Smad/Dpc4, and β‐catenin, and genetic mutations such as KRAS, BRAF, and GNAS mutations in 69 patients with ampullary adenocarcinoma to clarify their relationships with clinicopathological findings and subtypes.ResultsKaplan–Meier survival analysis indicated that abnormal p53 labeling was significantly associated with a shorter overall survival. MUC1‐positive and MUC2‐negative expressions were significantly associated with lymphatic invasion, pancreatic invasion, lymph node metastasis, and advanced UICC stage. The KRAS mutation was significantly associated with large tumor size and pancreatic invasion. There were 35 intestinal (50%), 15 pancreatobiliary (22%), and 11 mixed subtype (16%) tumors. Patients with the mixed subtype showed significantly poor outcome. The invasiveness of the mixed subtype was similar to that of the pancreatobiliary subtype; moreover, the mixed subtype showed a high incidence of abnormal β‐catenin immunolabeling (73%).ConclusionsProtein expression and genetic mutation are clinically associated with the characteristics of ampullary adenocarcinoma. The mixed subtype may have a distinct tumor nature as compared to other two major subtypes. J. Surg. Oncol. 2016;114:119–127. © 2016 Wiley Periodicals, Inc.