bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic review of antibiotic treatment for acute calculous cholecystitis
Authors: van Dijk A H , de Reuver P R , Tasma T N , van Dieren S , Hugh T J , Boermeester M A 
Published: April 2016

AbstractBackgroundIntravenous antibiotics are frequently used in the initial management of acute calculous cholecystitis (ACC), although supportive care alone preceding delayed elective cholecystectomy may be sufficient. This systematic review assessed the success rate of antibiotics in the treatment of ACC.MethodsA systematic search of MEDLINE, Embase and Cochrane Library databases was performed. Primary outcomes were the need for emergency intervention and recurrence of ACC after initial non-operative management of ACC. Risk of bias was assessed. Pooled event rates were calculated using a random-effects model.ResultsTwelve randomized trials, four prospective and ten retrospective studies were included. Only one trial including 84 patients compared treatment with antibiotics to that with no antibiotics; there was no significant difference between the two groups in terms of length of hospital stay and morbidity. Some 5830 patients with ACC were included, of whom 2997 had early cholecystectomy, 2791 received initial antibiotic treatment, and 42 were treated conservatively. Risk of bias was high in most studies, and all but three studies had a low level of evidence. For randomized studies, pooled event rates were 15 (95 per cent c.i. 10 to 22) per cent for the need for emergency intervention and 10 (5 to 20) per cent for recurrence of ACC. The pooled event rate for both outcomes combined was 20 (13 to 30) per cent.ConclusionAntibiotics are not indicated for the conservative management of ACC or in patients scheduled for cholecystectomy.
ChemInform Abstract: New Environment for a Two‐Dimensional Topological Insulator with Hexagonal Channels Hosting Diiodido‐Bismuthate(I) Anions in a Singlet State.
Authors: Rasche Bertold , Van den Broek Wouter , Ruck Michael 
Published: April 2016

AbstractBi38Pt9I14 (I) is obtained as the major product aside of minor amounts of Bi2Pt by annealing mixtures of Bi, Pt, and BiI3 (290 °C, 1 week).
ChemInform Abstract: Synthesis and Characterization of Three New Layered Vanadium Tellurites, MVTe2O8 (M: Al, Ga, and Mn): Three‐Dimensional (3‐D) Antiferromagnetic Behavior of MnVTe2O8 with a Zigzag S = 2 Spin Chain.
Authors: Bae Su‐whan , Yoo Jisun , Lee Suheon , Choi Kwang Yong , Ok Kang Min 
Published: April 2016

AbstractThe isostructural compounds (IVa, b) and (VII) crystallize in the space group P21/n with Z = 4 (single crystal and powder XRD).
ChemInform Abstract: Indium versus Gold Catalysis in Dehydrative Reactions with Allylic Alcohols.
Authors: Webster Stacey , Schaefer Louise , Barker Graeme , Lee Ai‐Lan 
Published: April 2016

AbstractIndium(III) chloride is a more efficient catalyst than gold catalysts in dehydrative reactions of allylic alcohols with alcohols, thioacid, and thiophenols.
ChemInform Abstract: A Chemoselective α‐Aminoxylation of Aryl Ketones: A Cross Dehydrogenative Coupling Reaction Catalyzed by Bu4NI.
Authors: Siddaraju Yogesh , Prabhu Kandikere Ramaiah 
Published: April 2016

AbstractDiethyl ketone, acetophenone as well as benzoylacetone do not yield the corresponding products.
ChemInform Abstract: Catalytic Intramolecular Ketone Alkylation with Olefins by Dual Activation.
Authors: Lim Hee Nam , Dong Guangbin 
Published: April 2016

AbstractThe ruthenium‐catalyzed Conia‐ene‐type intramolecular cyclization of keto olefins (I) and (V) gives rise to cyclohexane (II) and decalinone (VI), whilst rhodium catalysts are used for the formation of five‐membered ring in compounds (IV), (VIII), (X), and (XII).
ChemInform Abstract: Reinvestigation of a Catalytic, Enantioselective Alkene Dibromination and Chlorohydroxylation.
Authors: Denmark Scott E. , Carson Nessa 
Published: April 2016

AbstractThorough reinvestigation of the title reactions reveals that in contrast to previously published results the reactions do not deliver the products in very high yields and with high to very high enantiomeric excesses, but in often significantly lower yields and with no enantioselectivity at all.
ChemInform Abstract: Lewis Acid Catalyzed Synthesis of α‐Trifluoromethyl Esters and Lactones by Electrophilic Trifluoromethylation.
Authors: Katayev Dmitry , Matousek Vaclav , Koller Raffael , Togni Antonio 
Published: April 2016

AbstractThe utility of the scalable protocol is demonstrated by further transformation of one lactone product via ring opening reactions.
ChemInform Abstract: Synthesis of α‐Hydroxycarboxylic Acid Anilides via Copper‐Catalyzed C—N Coupling of α‐Hydroxyamides with Aryl Halides.
Authors: Li Zhijie , Wen Quan , Zhou Lihong , Deng Xingmei , Zeng Qingle 
Published: April 2016

AbstractVarious aryl and alkyl substituted α‐hydroxyamides are successfully coupled with aryl bromides and iodides.
ChemInform Abstract: Copper(I)‐Catalyzed Amidation Reaction of Organoboronic Esters and Isocyanates.
Authors: Lew Tedrick Thomas Salim , Lim Diane Shu Wen , Zhang Yugen 
Published: April 2016

AbstractVarious amides are simply and efficiently synthesized from organoboronic esters (II) and isocyanates using a ligand‐free copper(I) catalyst.
ChemInform Abstract: Structurally Diverse π‐Extended Conjugated Polycarbo‐ and Heterocycles Through Pd‐Catalyzed Autotandem Cascades.
Authors: Barroso Raquel , Cabal Maria‐Paz , Badia‐Laino Rosana , Valdes Carlos 
Published: April 2016

AbstractThe Pd‐catalyzed reaction between 2,2′‐dibromobiphenyls and related systems with tosylhydrazones gives rise to novel π‐extended conjugated polycarbo‐ and heterocycles through an auto‐tandem process involving a cross‐coupling followed by an intramolecular Heck cyclization.
ChemInform Abstract: Asymmetric Synthesis of β‐Trifluoromethyl‐β‐amino Acids, Including Highly Sterically Constrained α,α‐Dialkyl Derivatives.
Authors: Dai Yanling , Xie Chen , Mei Haibo , Han Jianlin , Soloshonok Vadim A. , Pan Yi 
Published: April 2016

AbstractTitle compounds are synthesized via Mannich addition reaction of chiral trifluoroacetaldimine and lithium enolates of alkyl acetates.
ChemInform Abstract: Hydrogen‐Bond Directed Regioselective Pd‐Catalyzed Asymmetric Allylic Alkylation: The Construction of Chiral α‐Amino Acids with Vicinal Tertiary and Quaternary Stereocenters.
Authors: Wei Xuan , Liu Delong , An Qianjin , Zhang Wanbin 
Published: April 2016

AbstractThe scalable title reaction of azlactones with 4‐aryl, 4‐alkenyl or 4‐alkyl‐substituted vinyl‐1,3‐dioxolan‐2‐ones provides the amino acid products with excellent regio‐ and diastereoselectivities and often very high enantioselectivities.
ChemInform Abstract: DBU‐Mediated Metal‐Free Oxidative Cyanation of α‐Amino Carbonyl Compounds: Using Molecular Oxygen as the Oxidant.
Authors: Li Lei , Wang Qian , Liu Pei , Meng Hua , Kan Xing‐Lan , Liu Qun , Zhao Yu‐Long 
Published: April 2016

AbstractThis DBU‐mediated oxidative cyanation of α‐amino carbonyl compounds using air as the sole oxidant involves a tandem oxidation/Strecker reaction/oxidation process and provides an efficient method for the construction of α‐iminonitriles.
ChemInform Abstract: Lewis Base Activation of Silyl Acetals: Iridium‐Catalyzed Reductive Horner—Wadsworth—Emmons Olefination.
Authors: Dakarapu Udaya Sree , Bokka Apparao , Asgari Parham , Trog Gabriela , Hua Yuanda , Nguyen Hiep H. , Rahman Nawal , Jeon Junha 
Published: April 2016

AbstractA convenient scalable transformation of multiple challenging aryl, hetaryl, alkyl, and alkinyl esters as well as diesters into silyl acetals and the in‐situ transformation of the latter into enoates is elaborated.
ChemInform Abstract: Visible‐Light‐Driven Photocatalytic Initiation of Radical Thiol—Ene Reactions Using Bismuth Oxide.
Authors: Fadeyi Olugbeminiyi O. , Mousseau James J. , Feng Yiqing , Allais Christophe , Nuhant Philippe , Chen Ming Z. , Pierce Betsy , Robinson Ralph 
Published: April 2016

AbstractThe reaction has a vast substrate scope and tolerates multiple functional groups, thus allowing for the diversification of complex biomolecules and active pharmaceutical agents.
ChemInform Abstract: Chiral Terpene Auxiliaries III: Spiroborate Esters from (1R,2S,3R,5R)‐3‐Amino‐apopinan‐2‐ol as Highly Effective Catalysts for Asymmetric Reduction of Ketones with Borane.
Authors: Cwiklinska Marta , Krzeminski Marek P. , Tafelska‐Kaczmarek Agnieszka 
Published: April 2016

AbstractSpiroborate esters derived from terpene amino alcohols, (S)‐prolinol, and 2‐aminoethanol are employed as catalysts in the borane reduction of acetophenone and other aryl alkyl as well as halogenated ketones.
ChemInform Abstract: Synthesis of Nitriles from Aldoximes and Primary Amides Using XtalFluor‐E.
Authors: Keita Massaba , Vandamme Mathilde , Paquin Jean‐Francois 
Published: April 2016

AbstractA broad range of aryl, hetaryl, alkenyl, benzyl, and alkyl substituted aldoximes as well as primary amides is successfully transformed into the corresponding nitriles, with the aldoximes often providing higher product yields than the amides.
ChemInform Abstract: Dehydration of Aldoximes Using PhSe(O)OH as the Pre‐Catalyst in Air.
Authors: Zhang Xu , Sun Jingjing , Ding Yuanhua , Yu Lei 
Published: April 2016

AbstractThe reaction tolerates aryl, hetaryl, and alkyl substituted aldoxime substrates while delivering equally high or significantly higher product yields than previously developed methods.
ChemInform Abstract: Rhodium‐Catalyzed Oxidative Decarbonylative Heck‐Type Coupling of Aromatic Aldehydes with Terminal Alkenes.
Authors: Kang Lei , Zhang Feng , Ding Lin‐Ting , Yang Luo 
Published: April 2016

AbstractThe coupling of various readily available aromatic aldehydes with terminal alkenes leads to 1,2‐disubstituted alkenes with good regioselectivity and in most cases a E:Z ratio of <20:1.
ChemInform Abstract: An Efficient Green Synthesis of 2‐Arylbenzothiazole Analogues as Potent Antibacterial and Anticancer Agents.
Authors: Chhabra Mohit , Sinha Sohini , Banerjee Swagata , Paira Priyankar 
Published: April 2016

AbstractA novel and green approach for the synthesis of the title benzothiazole derivatives (III) is given.
ChemInform Abstract: Multicomponent Reactions of Acetoacetanilide Derivatives with Aromatic Aldehydes and Cyanomethylene Reagents to Produce 4H‐Pyran and 1,4‐Dihydropyridine Derivatives with Antitumor Activities.
Authors: Azzam Rasha Abdallah , Mohareb Rafat Milad 
Published: April 2016

AbstractA convenient multicomponent reaction approach for the synthesis of a variety of novel pyran and dihydropyridine derivatives is developed.
ChemInform Abstract: Pd(OAc)2/S=PPh3 Accelerated Activation of gem‐Dichloroalkenes for the Construction of 3‐Arylchromones.
Authors: Liu Jianming , Song Weiwei , Yue Yuanyuan , Liu Ren , Yi Hong , Zhuo Kelei , Lei Aiwen 
Published: April 2016

AbstractThe title compounds are prepared in modest to good yields from salicylaldehydes (I) and dichlorobenzylidenemethanes (II), (IV), and (VI).
ChemInform Abstract: Bipyridine Carbaldehydes as Electrophiles in the Morita—Baylis—Hillman Reaction: Synthesis of Highly Functionalized Bipyridyl Ligands and a Macrocycle.
Authors: Gouthaman Siddan , Periyaraja Somasundharam , Shanmugam Ponnusamy 
Published: April 2016

AbstractA simple and efficient Morita—Baylis—Hillman (MBH) reaction of bipyridine carbaldehydes and unexplored activated alkenes affords highly functionalized bipyridyl ligands.
ChemInform Abstract: Convenient Synthesis of Functionalized 6‐Styryl‐1,4,5,6‐tetrahydropyridines Through a Domino [2 + 2 + 2] Cycloaddition Reaction.
Authors: Zhang Jing , Yang Wen‐Juan , Sun Jing , Yan Chao‐Guo 
Published: April 2016

AbstractThe domino cycloaddition of α,β‐unsaturated N‐aryl aldimines, acetylenedicarboxylates, and arylidenemalononitriles in dry MeCN at room temperature affords 6‐styryl‐l,4,5,6‐tetrahydropyridines in good yields with various cis/trans ratios.
ChemInform Abstract: Cationic Cobalt(III)‐Catalyzed Aryl and Alkenyl C—H Amidation: A Mild Protocol for the Modification of Purine Derivatives.
Authors: Liang Yujie , Liang Yu‐Feng , Tang Conghui , Yuan Yizhi , Jiao Ning 
Published: April 2016

AbstractA Co‐catalyzed direct C—H amidation of unactivated (hetero)arenes and alkenes by l,4,2‐dioxazol‐5‐ones is presented.
ChemInform Abstract: Racemization‐Free Synthesis of Morpholinone Derivatives from α‐Amino Acids.
Authors: Samanta Sauvik , Mal Abhijit , Halder Sandipan , Ghorai Manas K. 
Published: April 2016

AbstractA simple strategy for the preparation of enantiomerically pure N‐tosyl or N‐benzyl protected morpholine, morpholinone, and morpholinecarboxylate derivatives is described.
ChemInform Abstract: Involudispirones A and B: Sesterterpenes Containing a Dispiro Ring from Stahlianthus involucratus.
Authors: Kong Ling‐Yi , et al.  
Published: April 2016

AbstractInvoludispirones A (I), and B (II), a pair of cytotoxic sesterpene stereoisomers, containing an unusual dioxadispiro[5.2.5.2]hexadecane ring system as their most intriguing structures, are isolated from the rhizomes of S.
ChemInform Abstract: Purine and Guanine Thioglycoside Analogues: Novel Synthesis of a New Class of Pyrazolo[1,5‐a][1,3,5]triazine‐4‐thioglycoside Derivatives under Microwave Activation.
Authors: Elgemeie Galal , Abu‐Zaied Mamdouh 
Published: April 2016

AbstractTitle compounds (VI) are simply synthesized under mild conditions by microwave‐assisted condensation of pyrazoles (I) with cyanocarbonimidodithioic acid (II) (or its sodium salt) leading to pyrazolotriazinethiol derivatives (III) as the key step, followed by coupling with bromo sugars (IV) and subsequent deprotection.
ChemInform Abstract: Epicochalasines A and B: Two Bioactive Merocytochalasans Bearing Caged Epicoccine Dimer Units from Aspergillus flavipes.
Authors: Zhu Hucheng , Chen Chunmei , Tong Qingyi , Li Xiao‐Nian , Yang Jing , Xue Yongbo , Luo Zengwei , Wang Jianping , Yao Guangmin , Zhang Yonghui 
Published: April 2016

Abstractisolation, structure elucidation, biogenetic pathway, and bioactivity of the new title cytochalasans possessing a hendecacyclic ring system containing an adamantyl cage
Scientific Argumentation for All? Comparing Teacher Beliefs About Argumentation in High, Mid, and Low Socioeconomic Status Schools
Authors: KATSH‐SINGER REBECCA , McNEILL KATHERINE L. , LOPER SUZANNA 
Published: April 2016

ABSTRACTEnsuring all students have opportunities to engage in scientific argumentation is a key goal for K–12 students. While research has shown that teachers’ beliefs about argumentation can impact their classroom instruction and that students in low socioeconomic status (SES) schools are less likely to experience challenging science learning, there is little research focused on the relationship between teachers’ argumentation beliefs and student SES. As such, in this study we explored the scientific argumentation beliefs of teachers in low, mid, and high SES schools. Participants were 34 teachers piloting a curriculum with a focus on scientific argumentation. Our data sources included a survey and interviews. While our analyses suggest that teachers in all types of schools believe argumentation is important, we observed some differences between the teachers of high, mid, and low SES students related to their beliefs about the goals of argumentation discourse and student capability to engage in argumentation. These findings suggest that accountability pressures may impact the beliefs of teachers of low SES students in ways not experienced by teachers of high SES students and offer implications for professional development for such teachers.
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency
Authors: Huemer Martina , Carvalho Daniel R. , Brum Jaime M. , Ünal Özlem , Coskun Turgay , Weisfeld‐Adams James D. , Schrager Nina L. , Scholl‐Bürgi Sabine , Schlune Andrea , Donner Markus G. , Hersberger Martin , Gemperle Claudio , Riesner Brunhilde , Ulmer Hanno , Häberle Johannes , Karall Daniela 
Published: April 2016

AbstractBackgroundArginase 1 (ARG1) deficiency is a rare urea cycle disorder (UCD). This hypothesis‐generating study explored clinical phenotypes, metabolic profiles, molecular genetics, and treatment approaches in a cohort of children and adults with ARG1 deficiency to add to our understanding of the underlying pathophysiology.MethodsClinical data were retrieved retrospectively from physicians using a questionnaire survey. Plasma aminoacids, guanidinoacetate (GAA), parameters indicating oxidative stress and nitric oxide (NO) synthesis as well as asymmetric dimethylarginine (ADMA) were measured at a single study site.ResultsNineteen individuals with ARG1 deficiency and 19 matched controls were included in the study. In patients, paraparesis, cognitive impairment, and seizures were significantly associated suggesting a shared underlying pathophysiology. In patients plasma GAA exceeded normal ranges and plasma ADMA was significantly elevated. Compared to controls, nitrate was significantly higher, and the nitrite:nitrate ratio significantly lower in subjects with ARG1 deficiency suggesting an advantage for NO synthesis by inducible NO synthase (iNOS) over endothelial NOS (eNOS). Logistic regression revealed no significant impact of any of the biochemical parameters (including arginine, nitrates, ADMA, GAA, oxidative stress) or protein restriction on long‐term outcome.ConclusionThree main hypotheses which must be evaluated in a hypothesis driven confirmatory study are delineated from this study: 1) clinical manifestations in ARG1 deficiency are not correlated with arginine, protein intake, ADMA, nitrates or oxidative stress. 2) GAA is elevated and may be a marker or an active part of the pathophysiology of ARG1 deficiency. 3) Perturbations of NO metabolism merit future attention in ARG1 deficiency.
Quarantine for Zika Virus? Where is the Science?
Authors: Koenig Kristi L. 
Published: April 2016

AbstractIn January 2016, the World Health Organization warned that Zika virus is “spreading explosively” in the Americas and that up to 4 million infections could be present worldwide within a year. Soon thereafter, some politicians and authors publicly advocated for quarantine of travelers returning from regions where mosquitoes carrying Zika virus are prevalent. The public health tool of quarantine can be used to prevent the spread of infection by restricting the movement of persons who have been exposed to a deadly disease that can be transmitted from person to person before symptom onset. With 80% of Zika virus infections being asymptomatic, no rapid test being available to detect the virus, and primary transmission being via the bites of certain mosquitoes, application of quarantine in this setting is not scientifically sound or practically feasible. Rather, public health interventions should focus on preventing bites from infected mosquitoes, counseling pregnant women on the risks of fetal microcephaly and other birth defects, and identifying patients with signs and symptoms of Guillain-Barré syndrome. As was seen in the Ebola virus disease outbreak of 2014, non-evidence-based factors can influence policy decisions. Public health experts must ensure that policy makers are informed that quarantine is not a scientifically sound approach for the control of Zika virus. (Disaster Med Public Health Preparedness. 2016;0:1–3)
Limiting the Number of Lumens in Peripherally Inserted Central Catheters to Improve Outcomes and Reduce Cost: A Simulation Study
Authors: Ratz David , Hofer Timothy , Flanders Scott A. , Saint Sanjay , Chopra Vineet 
Published: April 2016

BACKGROUNDThe number of peripherally inserted central catheter (PICC) lumens is associated with thrombotic and infectious complications. Because multilumen PICCs are not necessary in all patients, policies that limit their use may improve safety and cost.OBJECTIVETo design a simulation-based analysis to estimate outcomes and cost associated with a policy that encourages single-lumen PICC use.METHODSModel inputs, including risk of complications and costs associated with single- and multilumen PICCs, were obtained from available literature and a multihospital collaborative quality improvement project. Cost savings and reduction in central line–associated bloodstream infection and deep vein thrombosis events from institution of a single-lumen PICC default policy were reported.RESULTSAccording to our model, a hospital that places 1,000 PICCs per year (25% of which are single-lumen and 75% multilumen) experiences annual PICC-related maintenance and complication costs of $1,228,598 (95% CI, $1,053,175–$1,430,958). In such facilities, every 5% increase in single-lumen PICC use would prevent 0.5 PICC-related central line-associated bloodstream infections and 0.5 PICC-related deep vein thrombosis events, while saving $23,500. Moving from 25% to 50% single-lumen PICC utilization would result in total savings of $119,283 (95% CI, $74,030–$184,170) per year. Regardless of baseline prevalence, a single-lumen default PICC policy would be associated with approximately 10% cost savings. Findings remained robust in multiway sensitivity analyses.CONCLUSIONHospital policies that limit the number of PICC lumens may enhance patient safety and reduce healthcare costs. Studies measuring intended and unintended consequences of this approach, followed by rapid adoption, appear necessary.Infect Control Hosp Epidemiol 2016;37:811–817
Risk Factors for Surgical Site Infections Following Anterior Cruciate Ligament Reconstruction
Authors: Murphy Michael V. , Du Dongyi (Tony) , Hua Wei , Cortez Karoll J. , Butler Melissa G. , Davis Robert L. , DeCoster Thomas A. , Johnson Laura , Li Lingling , Nakasato Cynthia , Nordin James D. , Ramesh Mayur , Schum Michael , Von Worley Ann , Zinderman Craig , Platt Richard , Klompas Michael 
Published: April 2016

OBJECTIVETo determine the effect of graft choice (allograft, bone-patellar tendon-bone autograft, or hamstring autograft) on deep tissue infections following anterior cruciate ligament (ACL) reconstructions.DESIGNRetrospective cohort study.SETTING AND POPULATIONPatients from 6 US health plans who underwent ACL reconstruction from January 1, 2000, through December 31, 2008.METHODSWe identified ACL reconstructions and potential postoperative infections using claims data. A hierarchical stratified sampling strategy was used to identify patients for medical record review to confirm ACL reconstructions and to determine allograft vs autograft tissue implanted, clinical characteristics, and infection status. We estimated infection rates overall and by graft type. We used logistic regression to assess the association between infections and patients’ demographic characteristics, comorbidities, and choice of graft.RESULTSOn review of 1,452 medical records, we found 55 deep wound infections. With correction for sampling weights, infection rates varied by graft type: 0.5% (95% CI, 0.3%-0.8%) with allografts, 0.6% (0.1%–1.5%) with bone-patellar tendon-bone autografts, and 2.5% (1.9%–3.1%) with hamstring autograft. After adjusting for potential confounders, we found an increased infection risk with hamstring autografts compared with allografts (odds ratio, 5.9; 95% CI, 2.8–12.8). However, there was no difference in infection risk among bone-patellar tendon-bone autografts vs allografts (odds ratio, 1.2; 95% CI, 0.3–4.8).CONCLUSIONSThe overall risk for deep wound infections following ACL reconstruction is low but it does vary by graft type. Infection risk was highest in hamstring autograft recipients compared with allograft recipients and bone-patellar tendon-bone autograft recipients.Infect Control Hosp Epidemiol2016;37:827–833