bluuebunny/crossref_metadata_2025_split huggingface dataset:
Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate
Authors: Basso Maria Alexandra , Marques Cátia , Santos Marcos , Duarte Ana , Pissarra Hugo , Carreira L Miguel , Gomes Lídia , Valério-Bolas Ana , Tavares Luís , Santos-Gomes Gabriela , Pereira da Fonseca Isabel 
Published: February 2016

Case summary This work describes the diagnosis and successful treatment of a 2-year-old domestic cat infected with Leishmania species and presenting fever, and ulcerative and nodular skin lesions after being treated for pyodermatitis for 1 year without clinical improvement. After anamnesis the cat was submitted to a complete clinical examination. Blood was collected for determination of haematological and biochemical parameters, detection of feline leukaemia virus (FeLV), feline immunodeficiency virus (FIV), feline coronavirus (FCoV) and Leishmania amastigotes. Fine-needle aspiration puncture from the skin nodules was also performed. After definitive diagnosis the animal was treated and followed up over a 2 year period. The animal tested negative for FIV-specific antibodies, FeLV antigen and feline coronavirus RNA. Leishmania amastigotes in the skin nodules were confirmed by cytology and molecular diagnosis. Treatment was initiated with allopurinol, resulting in a slight clinical improvement. Thus, N-methyl-glucamine antimoniate was added and administered for 30 days, with complete closure of the ulcerative lesions in the hindlimbs requiring a surgical approach. Close monitoring of the patient in the following 24 months indicated that combined therapy was safe and clinical cure was achieved without further relapses or side effects. Relevance and novel information Considering the increasing number of feline leishmaniosis cases and the inconsistent results of most therapeutic protocols described in the literature, the use of new approaches, especially in refractory cases, is essential. Although the use of allopurinol and N-methyl-glucamine antimoniate is off-label in cats, in this case the combination treatment was followed by an extensive analytical monitoring, supporting their safety and effectiveness.
Distal polyneuropathy in an adult Birman cat with toxoplasmosis
Authors: Mari Lorenzo , Shelton G Diane , De Risio Luisa 
Published: February 2016

Case summary A 6-year-old female spayed Birman cat presented with a history of weight loss, stiff and short-strided gait in the pelvic limbs and reluctance to jump, progressing to non-ambulatory tetraparesis over 6 weeks. Poor body condition, dehydration and generalised muscle wastage were evident on general examination. Neurological examination revealed mildly depressed mental status, non-ambulatory flaccid tetraparesis and severely decreased proprioception and spinal reflexes in all four limbs. The neuroanatomical localisation was to the peripheral nervous system. Haematology, feline immunodeficiency virus/feline leukaemia virus serology, serum biochemistry, including creatine kinase and thyroxine, thoracic radiographs and abdominal ultrasound did not reveal significant abnormalities. Electromyography revealed fibrillation potentials and positive sharp waves in axial and appendicular muscles. Decreased motor conduction velocities and compound muscle action potential amplitudes were detected in ulnar and sciatic–tibial nerves. Residual latency was increased in the sciatic–tibial nerve. Histologically, several intramuscular nerve branches were depleted of myelinated fibres and a few showed mononuclear infiltrations. Toxoplasma gondii serology titres were compatible with active toxoplasmosis. Four days after treatment initiation with oral clindamycin the cat recovered the ability to walk. T gondii serology titres and neurological examination were normal after 11 and 16 weeks, respectively. Clindamycin was discontinued after 16 weeks. One year after presentation the cat showed mild relapse of clinical signs and seroconversion, which again resolved following treatment with clindamycin. Relevance and novel information To our knowledge, this is the first report of distal polyneuropathy associated with toxoplasmosis in a cat. This case suggests the inclusion of toxoplasmosis as a possible differential diagnosis for acquired polyneuropathies in cats.
Integration of Behavioral Health and Medical Services
Authors: Deavers Frances , DePesa Natasha , Mitchell Jonathan , Mazza Angela , Cassisi Jeffrey 
Published: February 2016

Objectives: This study aimed to assess patient satisfaction with behavioral health consultation in a primary and specialty care setting and to gauge patient interest in other behavioral health services. Methods: We surveyed patients with type 2 diabetes mellitus (N = 65), following a brief behavioral health consultation about their satisfaction with the experience and their interest in various behavioral health services. Doctoral students with master’s degrees in clinical psychology provided the consultations. Results: Patients were highly satisfied with behavioral health consultations and expressed moderate to high interest in various potential behavioral health services. Patients with more diabetes-related concerns were less satisfied with brief behavioral health consultations but reported greater interest in other behavioral health services. Conclusions: Results were used to build stakeholder support and guide expansion of integrated behavioral health services. Examining patient experience can help identify patients who need more extensive services and ensure that services are patient centered.
Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation
Authors: Mascarenhas Maria I. , Bacon Wendi A. , Kapeni Chrysa , Fitch Simon R. , Kimber Gillian , Cheng S. W. Priscilla , Li Juan , Green Anthony R. , Ottersbach Katrin 
Published: February 2016

Key Points
Emerging HSCs require Jak2 and Pi3k signaling for proliferation and survival. Embryonic HSCs are unaffected by the JAK2V617F mutation.
The ability to cross the blood–cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts
Authors: Williams Mark T. S. , Yousafzai Yasar M. , Elder Alex , Rehe Klaus , Bomken Simon , Frishman-Levy Liron , Tavor Sigal , Sinclair Paul , Dormon Katie , Masic Dino , Perry Tracey , Weston Victoria J. , Kearns Pamela , Blair Helen , Russell Lisa J. , Heidenreich Olaf , Irving Julie A. E. , Izraeli Shai , Vormoor Josef , Graham Gerard J. , Halsey Christina 
Published: February 2016

Key Points
More than 75% of primary diagnostic BCP-ALL samples engraft in the CNS in xenograft models. We find no evidence for selective trafficking to the CNS but show that CNS entry is a generic property of BCP-ALL cells.
Normal ABL1 is a tumor suppressor and therapeutic target in human and mouse leukemias expressing oncogenic ABL1 kinases
Authors: Dasgupta Yashodhara , Koptyra Mateusz , Hoser Grazyna , Kantekure Kanchan , Roy Darshan , Gornicka Barbara , Nieborowska-Skorska Margaret , Bolton-Gillespie Elisabeth , Cerny-Reiterer Sabine , Müschen Markus , Valent Peter , Wasik Mariusz A. , Richardson Christine , Hantschel Oliver , van der Kuip Heiko , Stoklosa Tomasz , Skorski Tomasz 
Published: February 2016

Key Points
Normal ABL1 is a tumor suppressor in BCR-ABL1–induced leukemia. Allosteric stimulation of the normal ABL1 kinase activity enhanced the antileukemia effect of ABL1 tyrosine kinase inhibitors.
Conditioned umbilical cord tissue provides a natural three-dimensional storage compartment as in vitro stem cell niche for human mesenchymal stroma/stem cells
Authors: Yang Yuanyuan , Melzer Catharina , Bucan Vesna , von der Ohe Juliane , Otte Anna , Hass Ralf 
Published: February 2016

Abstract
Background
The use of large amounts of human multipotent mesenchymal stroma/stem cells (MSC) for cell therapies represents a desirable property in tissue engineering and banking in the field of regenerative medicine.

Methods and results
Whereas cryo-storage of umbilical cord (UC) tissue pieces in liquid nitrogen without ingredients was associated with predominant appearance of apoptotic cells after thawing and re-culture, progressive growth of MSC was observed following use of cryo-medium. Moreover, conditioning of UC tissue pieces by initial explant culture and subsequent cryo-storage with cryo-medium accelerated a further MSC culture after thawing. These findings suggested that conditioning of UC tissue pieces provides an in vitro stem cell niche by maintenance of a 3-dimensional natural microenvironment for continuous MSC outgrowth and expansion. Indeed, culture of GFP-labeled UC tissue pieces was accompanied by increased outgrowth of GFP-labeled cells which was accelerated in conditioned UC tissue after cryo-storage. Moreover, cryopreserved conditioned UC tissue pieces in cryo-medium after thawing and explant culture could be cryopreserved again demonstrating renewed MSC outgrowth after repeated thawing with similar population doublings compared to the initial explant culture. Flow cytometry analysis of outgrowing cells revealed expression of the typical MSC markers CD73, CD90, and CD105. Furthermore, these cells demonstrated little if any senescence and cultures revealed stem cell-like characteristics by differentiation along the adipogenic, chondrogenic and osteogenic lineages.

Conclusions
Expression of MSC markers was maintained for at least 10 freeze/thaw/explant culture cycles demonstrating that repeated cryopreservation of conditioned UC tissue pieces provided a reproducible and enriched stem cell source.
(Why) are immigrants unhappy?
Authors: Kóczán Zsóka 
Published: February 2016

AbstractRecent studies suggest that migrants may be less satisfied with their ‘new’ lives than members of the host population and worry that this may be driven by cultural factors, such as feelings of not belonging. Motivated by this concern, this paper analyses the life satisfaction of immigrants once settled in the host country. We rely on the German Socio-Economic Panel’s immigrant sample for the years 1984–2010 and find that while immigrants are less satisfied than natives, this difference can be explained by factors related to economic integration, such as the details of their employment conditions, rather than cultural factors such as feelings of not belonging, which often loom large in the public mind.JEL codes:J15, K37, O15
High-mobility group box protein 1 promotes the survival of myeloid-derived suppressor cells by inducing autophagy
Authors: Parker Katherine H , Horn Lucas A , Ostrand-Rosenberg Suzanne 
Published: February 2016

Abstract
Myeloid-derived suppressor cells are immune-suppressive cells that are elevated in most individuals with cancer, where their accumulation and suppressive activity are driven by inflammation. As myeloid-derived suppressor cells inhibit anti-tumor immunity and promote tumor progression, we are determining how their viability is regulated. Previous studies have established that the damage-associated molecular pattern molecule high-mobility group box protein 1 drives myeloid-derived suppressor cell accumulation and suppressive potency and is ubiquitously present in the tumor microenvironment. As high-mobility group box protein 1 also facilitates tumor cell survival by inducing autophagy, we sought to determine if high-mobility group box protein 1 regulates myeloid-derived suppressor cell survival through induction of autophagy. Inhibition of autophagy increased the quantity of apoptotic myeloid-derived suppressor cells, demonstrating that autophagy extends the survival and increases the viability of myeloid-derived suppressor cells. Inhibition of high-mobility group box protein 1 similarly increased the level of apoptotic myeloid-derived suppressor cells and reduced myeloid-derived suppressor cell autophagy, demonstrating that in addition to inducing the accumulation of myeloid-derived suppressor cells, high-mobility group box protein 1 sustains myeloid-derived suppressor cell viability. Circulating myeloid-derived suppressor cells have a default autophagic phenotype, and tumor-infiltrating myeloid-derived suppressor cells are more autophagic, consistent with the concept that inflammatory and hypoxic conditions within the microenvironment of solid tumors contribute to tumor progression by enhancing immune-suppressive myeloid-derived suppressor cells. Overall, these results demonstrate that in addition to previously recognized protumor effects, high-mobility group box protein 1 contributes to tumor progression by increasing myeloid-derived suppressor cell viability by driving them into a proautophagic state.
HLA Genetic Discrepancy Between Latent Autoimmune Diabetes in Adults and Type 1 Diabetes: LADA China Study No. 6
Authors: Luo Shuoming , Lin Jian , Xie Zhiguo , Xiang Yufei , Zheng Peilin , Huang Gan , Li Xia , Liao Yu , Hagopian William A. , Wang Cong-Yi , Zhou Zhiguang 
Published: February 2016

Abstract

Context:
The discrepancies in terms of human leukocyte antigen (HLA)-DRB1-DQA1-DQB1 conferred risks between latent autoimmune diabetes in adults (LADA) and type 1 diabetes (T1D) patients remained almost completely unknown. The goal of the current study is to determine and compare HLA-conferred risks between LADA and T1D.

Design:
A case-control study was conducted in a representative Chinese data set containing 520 T1D patients, 562 LADA patients, and 1065 controls. The frequencies and odds ratios for HLA susceptible haplotypes and genotypes and for arginine at residue 52 in the DQ-α chain or aspartic acid at residue 57 in the DQ-β chain were analyzed.

Results:
DRB1*0405-DQA1*03-DQB1*0401 and DRB1*0901-DQA1*03-DQB1*0303 are the major LADA susceptible haplotypes, which also confer comparable risks for T1D (odds ratio 2.02 vs 2.20 and 1.61 vs 2.30, respectively). The strongly associated T1D haplotype DRB1*0301-DQA1*05-DQB1*0201 is also associated with LADA but confers only half of the T1D risk (odds ratio 2.65 vs 4.84). Interestingly, the most susceptible T1D haplotypes, DRB1*0901-DQA1*05-DQB1*0201, DRB1*0301-DQA1*03-DQB1*0201, and DRB1*0301-DQA1*03-DQB1*0303, are not associated with LADA. Genotypes for DR3/DR3, DR3/DR9, and DR9/DR9 are highly associated with T1D susceptibility, whereas only DR9/DR9 confers risk for LADA. DR3/DR3 is the high-risk genotype in Chinese T1D patients, which manifests similar risk as the DR3/DR4 genotype in Caucasians but with a lower frequency. DR9/DR9 is the high risk LADA genotype in Chinese. Alleles with DQ-α arginine at residue 52-positive, DQ-β aspartic acid at residue 57-negative, and their combination formed in cis or trans confer susceptibility to T1D but not to LADA.

Conclusion:
Our results suggest that LADA risk conferred by HLA-DRB1-DQA1-DQB1 loci in Chinese differs significantly from that of T1D risk. This information would be useful for classifying Asian LADA patients, which should provides novel insight into the understanding of its pathoetiology as well.
Prickle isoforms control the direction of tissue polarity by microtubule independent and dependent mechanisms
Authors: Sharp Katherine A. , Axelrod Jeffrey D. 
Published: February 2016

ABSTRACTPlanar cell polarity signaling directs the polarization of cells within the plane of many epithelia. While these tissues exhibit asymmetric localization of a set of core module proteins, in Drosophila, more than one mechanism links the direction of core module polarization to the tissue axes. One signaling system establishes a polarity bias in the parallel, apical microtubules upon which vesicles containing core proteins traffic. Swapping expression of the differentially expressed Prickle isoforms, Prickle and Spiny-legs, reverses the direction of core module polarization. Studies in the proximal wing and the anterior abdomen indicated that this results from their differential control of microtubule polarity. Prickle and Spiny-legs also control the direction of polarization in the distal wing (D-wing) and the posterior abdomen (P-abd). We report here that this occurs without affecting microtubule polarity in these tissues. The direction of polarity in the D-wing is therefore likely determined by a novel mechanism independent of microtubule polarity. In the P-abd, Prickle and Spiny-legs interpret at least two directional cues through a microtubule-polarity-independent mechanism.
Bank Lending under Conditions of Turbulence: Theory and Practice
Authors: Костерина  , Kosterina T. 
Published: February 2016

The article investigates the development problem within the bank lending
under current conditions in terms of the scientific and methodological support
of the credit process management. The main goal of the study is the analysis
of the credit theory evolution regarding implementation of the scientific
achievements’ results into the practice of crediting. The author focuses on
the opportunities for the realization of credit functions and on the factors
affecting this process.
The Value of E-commerce for the Country Economy
Authors: Сигарев  , Sigarev Aleksandr 
Published: February 2016

This article is devoted to research the benefits offered by e-commerce for
business and consumers. Internet significantly increases the company’s
marketing opportunities, helps to reduce company’s costs, simplifies and
reduces the cost of interaction with contractors. As for consumers, Internet
provides opportunities to find the most optimal price offers, helps to reduce
asymmetry of information, and simplifies the process of purchase. The benefits
at the micro-level impact on the economy as a whole, resulting in an increase
in output and effective demand.
Minority Right to Attend Religious Education in Indonesia
Authors: Raihani Raihani 
Published: February 2016

<p class="abstrak">In 2003, Indonesian government issued a new education law in which one of the articles (Article 12) states that student has the right to access religion class in school in accordance with his or her religion by teachers who share the faith. This particular article has a legal ramification that school --state and private-- by law must provide corresponding Religion Classes (RC) for each religious group of students in order to fulfil their very human basic right to access to and observe their religious and cultural teaching and practices. This paper presents findings of four different school case studies on the problem of access to RC by religious minority in schools in Indonesia. Minority in this paper refers to religious groups that are either numeric minority or subordinate majority at the micro school level, not in the macro national population. This paper argues that numeric minority in any context (micro or macro) is vulnerable to discrimination by the dominating majority when the law of social relations is not fairly implemented. The findings suggest that the right of religious minority groups in three of the four schools to access proper RC is stifled, particularly to access equal learning facilities. Numeric religious minority groups in these schools suffer from powerlessness. One case, however, demonstrates that the positional power of minority group reverses this logic of minority-powerlessness and puts the religious majority students in a subordinate position.</p><p class="abstrak">[Tahun 2003, pemerintah Indonesia mengeluarkan Undang-Undang Pendidikan yang pada pasal 12 menyatakan bahwa siswa mempunyai hak terhadap pelajaran agama di sekolah dengan guru yang mengajar sesuai dengan agamanya. Pasal ini mempunyai konsekuensi bahwa sekolah, baik swasta atau pun negeri, harus menyediakan kelas agama untuk setiap kelompok siswa untuk mendapatkan hak dasarnya guna melaksanakan agama dan ajarannya. Artikel ini menampilkan hasil penelitian dari empat sekolah dengan studi kasus pada persoalan kelas agama bagi kelompok minoritas. Istilah minoritas di sini merujuk pada kelompok agama yang sedikit jumlahnya atau kelompok kecil pada sekolah, bukan pada level nasional. Tulisan ini menegaskan bahwa minoritas pada konteks mikro atau makro sangat rentan terhadap perlakuan diskriminasi oleh kelompok mayoritas ketika hukum social tidak sepenuhnya dijalankan. Penemuan ini menegaskan bahwa hak keagamaan minoritas dalam tiga dari empat sekolah terganggu, terutama yang terkait dengan hak fasilitas belajar. Beberapa kelompok minoritas pada sekolah tersebut tak berdaya. Namun, satu kasus menunjukkan bahwa kondisi minoritas berbalik, justru kelompok mayoritas yang menjadi subordinasi.]</p>
Gruppenarbeit in Deutschland - Instrument zur Requalifizierung der Industriearbeit oder leere Worthülse?
Authors: Lay Gunter 
Published: February 2016

Abstract
Nachdem die Diskussionen um das Konzept der Gruppenarbeit in den zurückliegenden 30 Jahren in Deutschland mehrfach zwischen großen Hoffnungen und anschließender Desillusionierung oszillierten, scheint es mittlerweile an der Zeit, auf der Basis einer breiten quantitativen Empirie eine Zwischenbilanz zu den qualifikatorischen Effekten dieser Form der Arbeitsorganisation zu ziehen. Da die Zukunft der Industriearbeit in ihren Qualifikationsanforderungen Gegenstand vielfältiger Überlegungen ist, versucht der vorliegende Beitrag darzustellen, in welcher Beziehung unterschiedliche Formen der Gruppenarbeit mit industrieller Facharbeit stehen. Dabei wird deutlich, dass viele euphorische Erwartungen hinsichtlich einer Renaissance der Facharbeit in Folge der Verbreitung von Gruppenarbeit in der Empirie keine Entsprechung finden
Projekt „Glückliches Leben“. Zum Zusammenhang von Zeitnutzung und Glück bei berufstätigen Eltern
Authors: Schilling Elisabeth 
Published: February 2016

Abstract
Eine Befragung berufstätiger Eltern geht der Frage nach, welche Art von Zeitnutzung das Wohlbefinden dieser Gruppe fördert. Die Ergebnisse belegen, dass eine strategische Zeitnutzung sowie die Möglichkeit, Zeit zu planen, die Lebensqualität erhöht. Die Notwendigkeit dagegen, auf Erwerbsarbeit oder Familie zu verzichten, beeinflusst das Wohlbefinden negativ. Auch flexible Anpassung eigener Zeit an die äußeren Bedingungen übt einen negativen Einfluß aus.
Bestimmungsgründe und Auswirkungen familienfreundlicher Maßnahmen
Authors: Stumpf Christian 
Published: February 2016

Abstract
In einer schriftlichen Befragung von knapp 500 Unternehmen der Metropolregion Rhein-Neckar wurde das Angebot familienfreundlicher Maßnahmen und die Sicht der Unternehmen auf das Thema Vereinbarkeit von Familie und Beruf erhoben. Durch eine differenzierte Analyse familienfreundlicher Maßnahmen lassen sich spezifische Einflussfaktoren für die Bereiche Arbeitszeitmodelle, Elternförderung sowie einfacher und aufwendiger Kinderbetreuung herausarbeiten. Neben betrieblichen Merkmalen erweisen sich insbesondere Einstellungen der Personalverantwortlichen bzw. Geschäftsführer/-innen zur Vereinbarkeit und deren Informationsstand als relevante Einflussgrößen auf das Angebot familienfreundlicher Maßnahmen.
Schlagwörter Alternde Belegschaften, Arbeitsgestaltung, Arbeitsorganisation, Personal/Personalführung, Zukunft der Arbeit
Authors: Schütz Holger , Schütz Holger 
Published: February 2016

Abstract
Der Aufsatz widmet sich dem wenig erforschten Thema von Politikstrategien der Arbeitsvermittlung. Auf Basis einer Bestandsaufnahme der wichtigsten Vermittlungsstrategien wird zunächst eine Typologie von Vermittlungsansätzen entwickelt. Anschließend wird mit dem Ansatz der Fuzzy-Set-Idealtypen-Analyse für zwei Zeitpunkte vor und nach der jüngsten Reform der Arbeitsverwaltung überprüft, welche Vermittlungsstrategien empirisch auftreten und in welchem Maße diese den Modelltypen entsprechen. Die empirische Analyse demonstriert, dass sich die Vielfalt der Vermittlungsstrategien der deutschen Arbeitsagenturen im Zeitverlauf reduziert hat. Die Vermittlungsstrategien der sanktionierenden Aktivierung und der Arbeitgeberorientierung haben dabei an Gewicht zugenommen gegenüber dem Ansatz der fördernden Aktivierung.