bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electrochemical Biosensors in Diagnostic Medicine: Detecting Lung Cancer Biomarkers – A Comprehensive Review
Authors: Sales da Rocha Guilherme , Nicolini João Victor , Conceição Ferraz Helen 
Published: October 2024

AbstractElectrochemical biosensors use biomolecules, such as proteins, enzymes, and antibodies, to translate the analytical signals detected in a sample. They have diverse applications including pesticide detection in agriculture, water analysis in various sectors, and biomedical and forensic diagnostics. With the estimated number of cancer cases in the US in 2024 being over two million, particularly lung cancer, which is notoriously difficult to diagnose early, the integration of biosensors into the Point‐of‐care Testing (PoCT) strategy can significantly improve the detection of cancer biomarkers, contributing to early diagnosis and successful treatment. Three‐dimensional (3D) printing is a promising alternative for reducing production costs and customizing devices in various ways. This review highlights recent trends and research on the development of electrochemical biosensors for early detection of lung cancer. These biosensors are expected to be more sensitive and selective for a variety of real samples and are precise, accurate, and stable during their commercialization. Significant progress has been made in the development of electrochemical devices for the early diagnosis of lung cancer, with various biomarker anchoring and detection strategies addressed throughout the study. Overcoming these challenges is key to advancing the use of these biosensors, thus improving diagnostic accuracy and enabling the successful treatment of lung cancer patients.
Enhancement of kefir functionality by adding black elderberry and evaluation of its quality during storage
Authors: Barazi Ümran , Arslan Seher 
Published: October 2024

AbstractThe research explored the influences of 2% and 4% heat‐treated fresh elderberry fruit mash supplement and 0.5% and 1% dried elderberry powder supplement before and after fermentation in kefir production on certain features of kefir beverage. Antioxidant activity, total monomeric anthocyanin, and total phenolic content were 16.69–75.67 (μmol TE/kg), 14.64–88.20 (mg cyn‐3‐gly/kg), and 167.94–531.33 mg GAE/kg in the samples during storage, respectively. Total phenolic content and antioxidant activity were higher in kefir samples produced with elderberry powder when compared to the other samples. It was determined that L* and b* increased with the decrease in the fruit supplement in kefir production, and L* and b* values were mostly higher in kefirs with fruit supplement before fermentation. The highest ACE inhibitor activity was observed in the kefir sample (1‐DEPre sample) with 1% dried elderberry supplement before fermentation on the first day of storage. It was determined that the general appreciation scores were above 3, and the samples produced mostly with dried elderberry powder were appreciated more when compared to the samples produced with fresh elderberry.
Effect of Boiling and Roasting Treatments on the Nutrients, Lipid Quality, and Flavor of Peanuts
Authors: Zhang Ying , Zhu Weichao , Jin Yuanbao , Xu Jiyuan , Zhou Wenlong , Shen Tingting , Yang Anshu , Wu Zhihua , Chen Hongbing 
Published: October 2024

ABSTRACTRoasted peanuts (OPs) are more often used in daily life than boiled peanuts (BPs); the main reason may be related to the pleasurable flavor in OPs. This study comparatively investigated the effects of boiling and roasting on nutritional components contents, taste, and aroma to reveal the advantages of roasting in terms of the nutrition and flavor of peanuts. Results showed that boiling increased fat content to 54.47% of peanuts, diluted or reduced sugar content to an undetectable level, noticeably changed the contents of poly/monounsaturated fatty acids, and significantly decreased the content of free amino acid (FAA, 1.05 mg/g peanuts) in peanuts. Roasting simply decreased the contents of sugar and FAA to 2.78 and 1.82 mg/g peanuts, respectively. Compared with roasting, boiling had more discernible effects on fatty acids and FAAs. Both BPs and OPs have good dietary lipid quality. In terms of flavor, OPs had more FAAs (2 types) that contributed remarkably to the taste of peanuts than BPs (0 types), more volatile substances (40 types) than BPs (12 types), and a higher number of key volatile aroma components (8 types) than BPs (3 types). That is, roasting induced a relatively small effect on nutritional components and gave peanuts a richer taste and stronger aroma than boiling; therefore, roasting is an ideal peanut processing method. This study proved the different changes in peanuts caused by boiling and roasting on a material basis and corroborated the irreplaceability of roasting in peanut processing.
A Multispectral Blood Smear Background Images Reconstruction for Malaria Unstained Images Normalization
Authors: Doumun OULAI Solange , Dabo‐Niang Sophie , Zoueu Jérémie 
Published: October 2024

ABSTRACTMultispectral and multimodal unstained blood smear images are obtained and evaluated to offer computer‐assisted automated diagnostic evidence for malaria. However, these images suffer from uneven lighting, contrast variability, and local luminosity due to the acquisition system. This limitation significantly impacts the diagnostic process and its overall outcomes. To overcome this limitation, it is crucial to perform normalization on the acquired multispectral images as a preprocessing step for malaria parasite detection. In this study, we propose a novel method for achieving this normalization, aiming to improve the accuracy and reliability of the diagnostic process. This method is based on estimating the Bright reference image, which captures the luminosity, and the contrast variability function from the background region of the image. This is achieved through two distinct resampling methodologies, namely Gaussian random field simulation by variogram analysis and Bootstrap resampling. A method for handling the intensity saturation issue of certain pixels is also proposed, which involves outlier imputation. Both of these proposed approaches for image normalization are demonstrated to outperform existing methods for multispectral and multimodal unstained blood smear images, as measured by the Structural Similarity Index Measure (SSIM), Mean Squared Error (MSE), Zero mean Sum of Absolute Differences (ZSAD), Peak Signal to Noise Ratio (PSNR), and Absolute Mean Brightness Error (AMBE). These methods not only improve the image contrast but also preserve its spectral footprint and natural appearance more accurately. The normalization technique employing Bootstrap resampling significantly reduces the acquisition time for multimodal and multispectral images by 66%. Moreover, the processing time for Bootstrap resampling is less than 4% of the processing time required for Gaussian random field simulation.
Global meta‐analysis reveals the drivers of gut microbiome variation across vertebrates
Authors: Xie Yong , Xu Songsong , Xi Yufei , Li Zixin , Zuo Erwei , Xing Kai , Bai Lijing , Li Kui 
Published: October 2024

AbstractShifts in gut microbial diversity and structure are one route by which vertebrate hosts adapt to local environmental conditions. However, recent studies have mostly been limited to a single species, small sample sizes, or restricted geographic ranges. Therefore, drawing a global picture of vertebrate gut microbiome diversity, community structure, and determinants for their adaptive shifts remains to be elucidated. We here collected 6508 samples from 113 vertebrate species covering diverse classes, feeding behaviors, and host habitats based on 16S rRNA gene sequencing. The results showed that host diet pattern had a significant impact on gut microbiome variation, which might drive taxonomic and functional contents of gut microbiome across vertebrates. Of note, the phylum Fusobacteria were enriched in carnivorous vertebrate gut while herbivorous vertebrate gut selectively increased the abundance of Verrucomicrobia. Also, climate factors were strongly associated with gut microbiome variation across vertebrates. Interestingly, we found that the abundance of microbiota belonging to Bacteroidetes increased gradually while the members from Proteobacteria showed a decreasing trend from high‐ to low‐latitude zones, potentially contributing to vertebrate adaptation to local climate condition. Additionally, we comprehensively deciphered the common antibiotic resistomes and their potential mobility between terrestrial vertebrate gut microbiome (n = 487) and their sympatric soil biological environment samples (n = 203) by integrating metagenomic sequencing datasets. Particularly, potential horizontal antibiotic resistance genes (e.g., bacA) transfers were detected between vertebrates gut microbiome and their sympatric soil biological environment. Together, our findings provide new evidence of how external environmental factors affect vertebrate gut microbiome variation.
Child marriage and well‐being in Central and Western Africa: A scoping review of costs and potential benefits for girls
Authors: Yendork Joana S. , Kliewer Wendy , Cyrus John W. 
Published: October 2024

AbstractIntroductionChild marriage is practiced widely in West and Central Africa with established links to several negative outcomes, particularly for girls. Although some reviews on predictors of the practice of child marriage exist, to date no review has focused on the costs and potential benefits to girls who have experienced child marriage.MethodWe conducted a scoping review of PubMed, African Index Medicus, Embase, PsycINFO, Web of Science, and Global Health and in the grey literature for studies on child marriage and adjustment up to October 2023. Studies were included if they assessed marriages where the female was younger than 18 at the time of marriage, were conducted in Central and Western African countries, explored positive and/or negative indicators of well‐being and mental health in the context of child marriage, were written in English, were published in a peer‐reviewed journal, or was a published thesis or dissertation, grey literature, or technical report, were conducted between 2014 and 2023, and presented qualitative, quantitative, or mixed‐method data.ResultsBased on the inclusion criteria, we included nine qualitative and four quantitative studies. Using the lens of Self‐Determination Theory, we found that overall child marriage compromised needs for autonomy, competence, and relatedness. Further, child marriage was linked to negative mental health outcomes. However, for some girls, child marriage was associated with some benefits including social recognition and elevated status in society.ConclusionFuture research on adjustment within the context of child marriage should focus on all aspects of well‐being as well as the processes associated with adjustment for girls.
Metastatic Small‐Cell Lung Carcinoma Infiltrating the Heart: A Rare Case Diagnosed Using Imaging Data
Authors: Zhang Tao , Han Zhengyang , Hou Suyun , Song Yi , Zhang Yongxiang , Wang Menghe 
Published: October 2024

ABSTRACTSmall‐cell lung carcinoma is a high‐grade aggressive disease that occurs most commonly in bronchial lung cancer, and metastasis to the heart is extremely rare. The diagnosis of metastatic small‐cell lung carcinoma infiltrating the heart remains challenging because of the variability of its clinical presentation. Hereinafter, we reported a case of a 41‐year‐old man who suffered from small‐cell lung cancer that invaded the pulmonary artery. The patient presented with chest tightness, dry cough, and deterioration in exercise tolerance and diagnosed at his imaging data, who had an uneventful recovery after surgical resection of the masses.
Passive UHF RFID tag achieving read ranges comparable to Battery‐Assisted Passive tags for containers, vessels, vehicles, and aircraft applications
Authors: Buenrostro‐Rocha Sergio , Medina‐Monroy José Luis , Herrera‐Charles Roberto 
Published: October 2024

AbstractA new, high‐gain, high‐efficiency, long‐range passive metamaterial UHF‐RFID tag is proposed. Measuring 16.1 × 8.1 × 1.6 cm, it integrates a modified taper‐shaped dipole antenna with the NXP UCODE 8 chip and an artificial magnetic conductor (AMC) structure shaped like a double open‐end wrench. This cost‐effective tag achieves read ranges comparable to those of battery‐assisted passive (BAP) tags, up to 64.7 m in a shipping container at 918 MHz and 56.7 m in free space at 928 MHz. Theoretical analysis shows moderate agreement with experimental validation in an anechoic chamber and outdoors. The proposed tag addresses challenging scenarios, enabling previously unattainable passive RFID applications. It supports vessel detection in maritime environments, with potential uses in automated access control at bridges, gates, and locks in smart waterways and premier marinas. It also supports multivehicle detection, allowing applications, such as streamlining emergency services and smart city traffic management. Furthermore, its capability extends to smart hangar applications, such as automatic updates to pilots' electronic logbooks and aircraft supervision.
Biological Control of Microbial Pectinolytic Plant Pathogens Causing Soft Rot of Fruits and Vegetables
Authors: Asmaa Benaissa , Merdia Bestami , Kheira Fellan , Rokaia Ben Malek , Chahrazade Djellout Nadine 
Published: October 2024

ABSTRACTIt is crucial to implement appropriate measures to prevent the spread of plant pathogens that lead to the decay of fruits and vegetables. From this perspective, we evaluated the biocontrol potential of five Bacillus‐plant growth promoting rhizobacteria (PGPR) strains against twenty‐one pectinolytic phytopathogens causing soft rot in fruits and vegetables. These phytopathogens had been previously studied. Three in vitro methods were utilized to accomplish this objective: competition, extraction of bioactive substances, and direct confrontation. The inhibitory effect of the direct confrontation method resulted in a slower growth of 11 microbial plant pathogens. In addition, it was noted that 11 strains of plant pathogens generated inhibitory constituents, while 15 plant pathogens produced inducible inhibitory substances. Furthermore, volatile inhibitory compounds were detected in the six tested strains. Overall, strains of PGPR‐Bacillus demonstrated strong antifungal and antibacterial properties against phytopathogens. These PGPR can be regarded as potential biocontrol agents for soft microbial rot in fruits and vegetables as well as producers of substances that effectively suppress plant diseases.
Carbon Sequestration and Soil Fertility Management in Sandy and Clayey Soils Revealed by Over Four Decades of Long‐Term Field Experiments in Thailand
Authors: Tancharoen Somrutai , Iwasaki Shinya , Watanabe Takeshi , Luanmanee Suphakarn , Nobuntou Wanida , Amonpon Wanlee , Chumsuwan Netirat , Paisancharoen Kobkiet , Bumrung Saowaree , Matsumoto Naruo 
Published: October 2024

ABSTRACTWe investigated the impact of organic matter (OM) application on soil organic carbon (SOC) sequestration and cassava yield in sandy (sand content > 72% and > 62%) and clayey (sand content > 47%) soils through three long‐term experiments conducted from 1975 to 1976 in Thailand. Eight treatments—nitrogen (N), phosphorus (P), and potassium (K) fertilization, cassava residue (CR), and compost application (COM)—were assigned to the control (CT), N, NP, NK, NPK, CR, NPK + CR, and NPK + COM groups. Changes in SOC, cassava yield, and soil chemical properties, were recorded. Interactions of these parameters were visualized using structural equation modeling (SEM). SOC concentrations were determined at five different depths in 2021. A significant treatment effect was observed in the initial stage of the experiment in sandy soils. Conversely, in clayey soil, a significant effect was observed only in the later stage. SOC sequestration rates (mean ± SD of the three sites, Mg C ha−1 0.2 m−1) were in the order of NPK + COM (10.1 ± 6.5), NPK + CR (5.6 ± 3.1), CR (2.8 ± 2.0), NPK (2.0 ± 2.1), NK (1.9 ± 1.3), NP (1.8 ± 2.0), and N (1.2 ± 1.1). SEM highlighted the effect of OM application on SOC sequestration across the three sites. Furthermore, SOC increases positively influenced cassava yield in sandy but not in clayey soils. Vertical distribution of SOC showed consistent treatment effects in deeper soil layers, especially in sandy soils, underscoring the importance of considering deep soil layers for carbon sequestration.
Harvesting sustainability: how social capital fosters cohesive relationships between green social media influencers and consumers to drive electronic word‐of‐mouth behaviours
Authors: Cheung Man Lai , Leung Wilson K. S. , Chang Man Kit , Shi Si , Tse Sin Yan 
Published: October 2024

AbstractThis research explores how green social media influencers affect consumers’ electronic word‐of‐mouth behaviour regarding green products by developing cohesive relationships. Grounded in social capital theory and relational cohesion theory, this study aims to understand how green social media influencers can build cohesive relationships with their followers and the subsequent effects of these relationships using a mixed‐method research design. The quantitative study (Study 1) uses a sample of 471 social media users who follow and interact with at least one green social media influencer and employs partial least squares structural equation modelling to analyse the data. The results show that green social media influencers’ cognitive capital and relational capital significantly trigger social interaction frequency, which, in turn, evokes positive mood and reduces uncertainty. This process fosters cohesive relationships and drives electronic word‐of‐mouth behaviour about green products. The study also examines how gender moderates the impact of cognitive and relational capital on social interaction frequency and its subsequent effects on relational cohesion and electronic word‐of‐mouth behaviours. The subsequent qualitative study (Study 2) corroborates the quantitative results and provides complementary findings, enhancing the understanding of how green social media influencers can use their social capital to develop cohesive relationships with consumers and drive electronic word‐of‐mouth behaviours. This research provides significant insights into how green social media influencers can build cohesive relationships with consumers and improve their effectiveness in promoting green products through social capital.
Lymphatic‐specific methyltransferase‐like 3‐mediated m6A modification drives vascular patterning through prostaglandin metabolism reprogramming
Authors: Shi Lianjun , Lu Shuting , Han Xue , Ye Fan , Li Xiumiao , Zhang Ziran , Jiang Qin , Yan Biao 
Published: October 2024

AbstractLymphangiogenesis plays a pivotal role in the pathogenesis of various vascular disorders, including ocular vascular diseases and cancers. Deregulation of N6‐methyladenosine (m6A) modification has been identified as a key contributor to human diseases. However, the specific involvement of m6A modification in lymphatic remodeling remains poorly understood. In this study, we demonstrate that inflammatory stimulation and corneal sutures induce elevated levels of methyltransferase‐like 3 (METTL3)‐mediated m6A modification. METTL3 knockdown inhibits lymphatic endothelial viability, proliferation, migration, and tube formation in vitro. METTL3 knockdown attenuates corneal sutures‐induced lymphangiogenesis and intratumoral lymphangiogenesis initiated by subcutaneous grafts, consequently restraining corneal neovascularization, tumor growth, and tumor neovascularization in vivo. Mechanistically, METTL3 knockdown upregulates prostaglandin–endoperoxide synthase 2 expression through an m6A–YTHDF2‐dependent pathway, enhancing the synthesis of cyclopentenone prostaglandins (CyPGs). Aberrant CyPG production in lymphatic endothelial cells impairs mitochondrial oxidative phosphorylation, contributing to pathological lymphangiogenesis. Moreover, selective inhibition of METTL3 with STM2457 reduces m6A levels in lymphatic endothelial cells, effectively suppressing pathological lymphangiogenesis. This study provides compelling evidence that lymphatic‐specific METTL3 plays a critical role in vascular patterning through prostaglandin metabolism reprogramming. Thus, METTL3 emerges as a promising target for treating lymphangiogenesis‐related diseases.
Excess control of family board seats and corporate financing constraints
Authors: Yang Yuqi , Meng Tianle 
Published: October 2024

AbstractWe examine the relationship between excess control of family board seats (ECFBS) and financing constraints (FCs) using 2008–2021 data for listed family firms in China. We find that ECFBS intensifies Type II agency problems, thereby worsens corporate FCs. We also investigate the impact of family firm founder characteristics, family owner characteristics, and external shareholder equity structure on the ECFBS and FCs. Our findings provide evidence of the encroachment effect of family control.
Behavior in long‐run projects and elicited time preferences
Authors: Akin Zafer , Yavaş Abdullah 
Published: October 2024

AbstractWe investigate behavior in long‐run projects and its relationship with experimentally elicited time preferences. Participants engage in a longitudinal project requiring sustained real effort, with their time preferences estimated through monetary outcomes. We observe a tendency to front‐load real effort, with choices reflecting both present and future bias, the former being more prevalent and severe. We also find evidence of naive choice reversals. However, there is no support for the quasi‐hyperbolic discounting model in monetary choices, and its predictions do not align with real effort allocation patterns. Nevertheless, discount rate and present bias parameters derived from monetary outcomes demonstrate predictive power over real effort allocation.
An asymmetric tropical cyclone rainfall model in the Northern Vietnam coast
Authors: Angkanasirikul Warinthorn , Jian Wei , Lo Edmond Yat‐Man 
Published: October 2024

AbstractRainfall associated with landfalling tropical cyclones (TCs) along the Northern Vietnam coast is examined to develop an asymmetric parametric TC‐induced rainfall model starting from the axisymmetric Rain‐Climatology and Persistence (R‐CLIPER) model. We recalibrated the R‐CLIPER model (original R‐CLIPER denoted as NHC) against observed rainfall patterns of 14 landfalling TCs from 2001 to 2021 in the Northern Vietnam coast, while relaxing the model's underlying linear relationships. The recalibrated R‐CLIPER (denoted as Fit‐Ax), still axisymmetric, suggests that some parameters are better correlated with the normalized maximum wind speed using logarithmic and exponential relationships. Fit‐Ax reduces the 12‐hr total rainfall overall root‐mean‐square errors (RMSEs) and Bias magnitudes in the before‐ and after‐landfall periods from NHC for the entire 500‐km TC domain. We further redistribute the Fit‐Ax rainfall intensity across the four quadrants with respect to the TC forward motion to account for the observed large asymmetry in quadrant rainfall (version denoted as Fit‐As). The vertical wind shear (VWS) and landfall (before or after) are considered in this redistribution. Fit‐As generally outperforms Fit‐Ax and NHC in reproducing the observed rainfall distribution for the 14 TCs. At the quadrant level, both Fit‐Ax and Fit‐As show significant improvement in Bias over NHC. Fit‐As is further better overall in RMSE and Skill when weighted by quadrant rainfall volume. In pattern matching, Fit‐As produces the best grid‐averaged Pearson correlation coefficients for 11 TCs. In addition, its equitable threat scores (ETSs) are best beyond the 20‐mm rainfall threshold, with the maximum of 0.299 at the 90‐mm rainfall threshold. Thus, our locally fitted asymmetric rainfall model demonstrates improved capability in reproducing the historical TC‐induced rainfall along the Northern Vietnam coast.