bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protocol for the CONVERT trial—Concurrent ONce-daily VErsus twice-daily RadioTherapy: an international 2-arm randomised controlled trial of concurrent chemoradiotherapy comparing twice-daily and once-daily radiotherapy schedules in patients with limited stage small cell lung cancer (LS-SCLC) and good performance status
Authors: Faivre-Finn Corinne , Falk Sally , Ashcroft Linda , Bewley Michelle , Lorigan Paul , Wilson Elena , Groom Nicki , Snee Michael , Fournel Pierre , Cardenal Felipe , Bezjak Andrea , Blackhall Fiona 
Published: January 2016

IntroductionConcurrent ONce-daily VErsus twice-daily RadioTherapy (CONVERT) is the only multicentre, international, randomised, phase III trial open in Europe and Canada looking at optimisation of chemoradiotherapy (RT) in limited stage small cell lung cancer (LS-SCLC). Following on from the Turrisi trial of once-daily versus twice-daily (BD) concurrent chemoradiotherapy, there is a real need for a new phase III trial using modern conformal RT techniques and investigating higher once-daily radiation dose. This trial has the potential to define a new standard chemo-RT regimen for patients with LS-SCLC and good performance status.Methods and analysis447 patients with histologically or cytologically proven diagnosis of SCLC were recruited from 74 centres in eight countries between 2008 and 2013. Patients were randomised to receive either concurrent twice-daily RT(45 Gy in 30 twice-daily fractions over 3 weeks) or concurrent once-daily RT(66 Gy in 33 once-daily fractions over 6.5 weeks) both starting on day 22 of cycle 1. Patients are followed up until death. The primary end point of the study is overall survival and secondary end points include local progression-free survival, metastasis-free survival, acute and late toxicity based on the Common Terminology Criteria for Adverse Events V.3.0, chemotherapy and RTdose intensity.Ethics and disseminationThe trial received ethical approval from NRES Committee North West—Greater Manchester Central (07/H1008/229). There is a trial steering committee, including independent members and an independent data monitoring committee. Results will be published in a peer-reviewed journal and presented at international conferences.Trial registration numberISRCTN91927162; Pre-results.
Diagnostic accuracy of haemoglobin colour strip (HCS-HLL), a digital haemoglobinometer (TrueHb) and a non-invasive device (TouchHb) for screening patients with anaemia
Authors: Neogi Sutapa Bandyopadhyay , Negandhi Himanshu , Kar Rakhee , Bhattacharya Maitrayee , Sen Rajeev , Varma Neelam , Bharti Priyanka , Sharma Jyoti , Bhushan Himanshu , Zodpey Sanjay , Saxena Renu 
Published: January 2016

AimEstimation of haemoglobin (Hb) remains a challenge, particularly in outreach settings. There is a need to have a simple and cost-effective device to detect anaemia. Three devices (haemoglobin colour scale (HCS)-HLL (Hindustan Lifecare Limited), TrueHb V.1.1, TouchHb Alpha 1.1- non-invasive) have been developed in India recently. This study aimed to determine the diagnostic accuracy of these tests (index) for the screening of anaemia against haematological autoanalyzer (reference).MethodsThe study was conducted in four medical colleges of India. All consenting adult patients (>18 years of age) undergoing routine investigations were included. Each patient underwent the reference test and at least one index test. Outcome assessors for the index tests were blinded to the results of the reference test. Diagnostic accuracy was calculated using cut-offs proposed by WHO.ResultsA total of 5244 patients underwent the reference test while HCS-HLL, TrueHb and TouchHb tests were conducted on 2745, 2331 and 2874 patients respectively. The positive likelihood ratio of HCS-HLL using capillary blood (1.2), venous blood (1.7) and TouchHb (1.5) was lower than TrueHb capillary (3.7; 95% CI 3.3 to 4.2) and venous blood (5.7; 95% CI 4.9 to 6.6). TrueHb had a sensitivity of 74.4% (95% CI 71.9% to 76.8%) for venous and 82.0% (95% CI 79.8% to 89.2%) for capillary samples. The specificity was high (>75.0%). The area under receiver operating characteristic was close to 80.0%. Consistent results were seen for detection of severe anaemia.ConclusionsThe digital method (TrueHb) emerged as a better diagnostic method for screening anaemia. Its effectiveness should be established in outreach settings before further recommendation.
Novel model of direct and indirect cost–benefit analysis of mechanical embolectomy over IV tPA for large vessel occlusions: a real-world dollar analysis based on improvements in mRS
Authors: Mangla Sundeep , O'Connell Keara , Kumari Divya , Shahrzad Maryam 
Published: January 2016

BackgroundIschemic strokes result in significant healthcare expenditures (direct costs) and loss of quality-adjusted life years (QALYs) (indirect costs). Interventional therapy has demonstrated improved functional outcomes in patients with large vessel occlusions (LVOs), which are likely to reduce the economic burden of strokes.ObjectiveTo develop a novel real-world dollar model to assess the direct and indirect cost–benefit of mechanical embolectomy compared with medical treatment with intravenous tissue plasminogen activator (IV tPA) based on shifts in modified Rankin scores (mRS).MethodA cost model was developed including multiple parameters to account for both direct and indirect stroke costs. These were adjusted based upon functional outcome (mRS). The model compared IV tPA with mechanical embolectomy to assess the costs and benefits of both therapies. Direct stroke-related costs included hospitalization, inpatient and outpatient rehabilitation, home care, skilled nursing facilities, and long-term care facility costs. Indirect costs included years of life expectancy lost and lost QALYs. Values for the model cost parameters were derived from numerous resources and functional outcomes were derived from the MR CLEAN study as a reflective sample of LVOs. Direct and indirect costs and benefits for the two treatments were assessed using Microsoft Excel 2013.ResultsThis cost–benefit model found a cost–benefit of mechanical embolectomy over IV tPA of $163 624.27 per patient and the cost benefit for 50 000 patients on an annual basis is $8 181 213 653.77.ConclusionsIf applied widely within the USA, mechanical embolectomy will significantly reduce the direct and indirect financial burden of stroke ($8 billion/50 000 patients).
Inter-rater reliability of published flow diversion occlusion scales
Authors: Mazur Marcus D , Taussky Philipp , Shah Lubdha M , Winegar Blair , Park Min S 
Published: January 2016

BackgroundWith increasing use of flow-diverting stents for the treatment of intracranial aneurysms, standardized methods and a common language to evaluate angiographic outcomes are needed. Multiple grading scales have been developed for this purpose but none has been widely adopted.ObjectiveTo analyze these scales to determine interobserver reliability.MethodsFour independent assessors scored the intraprocedural angiograms of patients who underwent flow-diverting stent deployment for an intracranial saccular or fusiform aneurysm at our institution between October 2012 and June 2015. Angiographic outcome immediately after flow-diverting stent deployment was scored using three grading scales (Kamran–Byrne (KB), Simple Measurement of Aneurysm Residual after Treatment (SMART), and O'Kelley, Krings, Marotta (OKM)). Statistical analysis was performed using Light's κ for multiple raters (κ), Kendall's coefficient of concordance (W), and intraclass correlation (ICC).ResultsWe included the angiograms of 50 consecutive patients (mean age 58 years, range 30–79) who underwent flow-diverting stent deployment for an intracranial aneurysm (40 saccular, 10 fusiform). Six aneurysms were located in the posterior circulation. The inter-rater reliability was typically poor or fair: SMART aneurysm filling (κ=0.30, W=0.36, ICC=0.12), SMART parent vessel stenosis (κ=0.07, W=0.33, ICC=0.12), KB axis I (κ=0.24, W=0.50, ICC=0.25), KB axis II (κ=0.07, W=0.30, ICC=0.06), OKM aneurysm filling (κ=0.23, W=0.45, ICC=0.13), OKM contrast stasis (κ=0.36,W=0.71, ICC=0.54).ConclusionsExisting flow-diverting stent grading scales have low inter-rater reliability for most categories.
Predicting fracture risk in osteoporosis: the use of fracture prediction tools in an osteoporosis clinic population
Authors: Aw Darren , Thain Jennifer , Ali Aamer , Aung Thanda , Chua Wei Mei , Sahota Opinder , Weerasuriya Namal , Marshall Lindsey , Kearney Fiona , Masud Tahir 
Published: January 2016

AbstractBackgroundIn the UK, the National Institute for Health and Care Excellence recommends either fracture risk assessment tool (FRAX) or QFracture to estimate the 10 year fracture risk of individuals. However, it is not known how these tools compare in determining risk and subsequent treatment using set intervention thresholds or guidelines.MethodsThe 10 year major osteoporotic (MO) and hip (HI) fracture risks were calculated for 100 women attending osteoporosis clinic in 2010 using FRAX and QFracture, and subsequent agreement to treatment between the tools was looked at using National Osteoporosis Foundation and National Bone Health Alliance thresholds (FRAX-20/3 and QFracture 20/3). We also looked at using these thresholds for QFracture and comparing them with the National Osteoporosis Guideline Group (NOGG) guidelines for FRAX (FRAX-NOGG).ResultsThe 10 year risk for MO fracture for FRAX was 17.0% (IQR 10.8–24.0) and that of QFracture was 15.8% (IQR 9.5–27.7) (p=0.732). The 10 year risk for HI fracture for FRAX was 5.0% (IQR 2.1–8.9) and that of QFracture was 8.1% (IQR 2.5–21.6) (p&lt;0.001). The agreement between FRAX-20/3 and QFracture-20/3 was greater than the agreement between FRAX-20/3 and FRAX-NOGG or QFracture-20/3 and FRAX-NOGG.ConclusionsThe calculated 10 year risk for MO fracture between FRAX and QFracture was similar, whereas that of HI fracture was significantly different. The agreement to treatment between QFracture-20/3 and FRAX-NOGG was only 45%. Treatment decisions can differ depending on the fracture calculation tool used when coupled with certain intervention thresholds or guidelines.
New results in searching for axions by astronomical methods
Authors: Gnedin Yu. N. , Piotrovich M. Yu. 
Published: January 2016

We discuss the astronomical methods of searching for light Goldstone bosons (axions and arions). The basic idea is to use processes of coupling between axions and photons: a) the axion decay into two photons; b) the transformation process of photons into axions (arions) in the magnetic fields of stars and also of interstellar and intergalactic media; c) the inverse process of transformations of axions (arions) which are generated into cores of stars into X-ray photons. The decaying axions affect upon the diffuse extragalactic background radiation, the brightness of the night sky and especially on the intergalactic light of clusters of galaxies due to generation of the axion radiative decay emission line. The processes (b) and (c) are strongly dependent on polarization state of photon and may produce a noticeable amount of linear polarization.
Effectiveness and safety of rivaroxaban therapy in daily-care patients with atrial fibrillation
Authors: Hecker Judith , Marten Sandra , Keller Loretta , Helmert Sindy , Michalski Franziska , Werth Sebastian , Sahin Kurtulus , Tittl Luise , Beyer-Westendorf Jan 
Published: January 2016

SummaryThe effectiveness and safety of rivaroxaban for stroke prevention in atrial fibrillation (SPAF) demonstrated in ROCKET AF needs to be confirmed in daily care. To evaluate effectiveness and safety of rivaroxaban therapy in SPAF patients in daily care, we used data from an ongoing, prospective, non-interventional registry of more than 2700 patients on novel oral anticoagulants in daily care. Between October 1, 2011 and February 28, 2013, a total of 1204 SPAF patients receiving rivaroxaban were enrolled. During a mean follow-up of 796.2 ± 207.3 days, the combined endpoint of stroke/transient ischaemic attack/systemic embolism occurred at a rate of 2.03/100 patient-years in the intention-totreat analysis (95 % confidence interval [CI] 1.5–2.7) and at 1.7/100 patient-years in the on-treatment analysis (events within 3 days after last intake). On-treatment rates were higher in patients selected for 15 mg rivaroxaban (n=384) once daily [OD] compared with the 820 patients selected for 20 mg OD (2.7 [95 % CI 1.6–4.2] vs 1.25/100 patient-years [95 % CI 0.8–1.9]). On treatment, major bleeding occurred at a rate of 3.0/100 patient-years and significantly more often in patients receiving the 15 mg OD dose compared with the 20 mg OD dose (4.5 vs 2.4/100 patient-years). Rivaroxaban treatment discontinuation occurred in a total of 277 patients during follow-up (12.0/100 patientyears in Kaplan-Meier analysis). Our data contribute to the confirmation of effectiveness and relative safety of rivaroxaban in daily-care patients. Furthermore, rivaroxaban discontinuation rates were considerably lower than those reported for vitamin K antagonists.Supplementary Material to this article is available online at www.thrombosis-online.com.
Evaluation of Monthly Satellite-Derived Precipitation Products over East Africa
Authors: Cattani E. , Merino A. , Levizzani V. 
Published: January 2016

Abstract
East Africa experienced in the 2001–11 time period some of the worst drought events to date, culminating in the high-impact drought of 2010/11. Long-term monitoring of precipitation is thus essential, and satellite-based precipitation products can help in coping with the relatively sparse rain gauge ground networks of this area of the world. However, the complex topography and the marked geographic variability of precipitation in the region make precipitation retrieval from satellites problematic and product validation and intercomparison necessary. Six state-of-the-art monthly satellite precipitation products over East Africa during the 2001–09 time frame are evaluated. Eight areas (clusters) are identified by investigating the precipitation seasonality through the Global Precipitation Climatology Centre (GPCC) climatological gauge data. Seasonality was fully reproduced by satellite data in each of the GPCC-identified clusters. Not surprisingly, complex terrain (mountain regions in particular) represents a challenge for satellite precipitation estimates, as demonstrated by the standard deviations of the six-product ensemble. A further confirmation comes from the comparison between satellite estimates and rain gauge measurements as a function of terrain elevation. The 3B42 product performs best, although the satellite–gauge comparative analysis was not completely independent since a few of the products include a rain gauge bias correction.
Development and Evaluation of High-Resolution Climate Simulations over the Mountainous Northeastern United States
Authors: Winter Jonathan M. , Beckage Brian , Bucini Gabriela , Horton Radley M. , Clemins Patrick J. 
Published: January 2016

Abstract
The mountain regions of the northeastern United States are a critical socioeconomic resource for Vermont, New York State, New Hampshire, Maine, and southern Quebec. While global climate models (GCMs) are important tools for climate change risk assessment at regional scales, even the increased spatial resolution of statistically downscaled GCMs (commonly ~⅛°) is not sufficient for hydrologic, ecologic, and land-use modeling of small watersheds within the mountainous Northeast. To address this limitation, an ensemble of topographically downscaled, high-resolution (30″), daily 2-m maximum air temperature; 2-m minimum air temperature; and precipitation simulations are developed for the mountainous Northeast by applying an additional level of downscaling to intermediately downscaled (⅛°) data using high-resolution topography and station observations. First, observed relationships between 2-m air temperature and elevation and between precipitation and elevation are derived. Then, these relationships are combined with spatial interpolation to enhance the resolution of intermediately downscaled GCM simulations. The resulting topographically downscaled dataset is analyzed for its ability to reproduce station observations. Topographic downscaling adds value to intermediately downscaled maximum and minimum 2-m air temperature at high-elevation stations, as well as moderately improves domain-averaged maximum and minimum 2-m air temperature. Topographic downscaling also improves mean precipitation but not daily probability distributions of precipitation. Overall, the utility of topographic downscaling is dependent on the initial bias of the intermediately downscaled product and the magnitude of the elevation adjustment. As the initial bias or elevation adjustment increases, more value is added to the topographically downscaled product.
Being Wheeled or Walking
Authors: Annemans Margo , Audenhove Chantal Van , Vermolen Hilde , Heylighen Ann 
Published: January 2016

Objective: In this article, we explore what a different way of moving—being wheeled versus walking—means for the spatial experience of day surgery patients. Background: Day surgery centers can be conceived in very different manners. Some are organized similar to traditional hospital admittance; others are located in a specifically designed part of the hospital and receive patients as guests who walk through the entire procedure. Methods: We conducted semistructured interviews with 37 patients at two distinct day surgery centers. Results: Despite the different managerial concepts and corresponding spatial designs, in both centers, patients’ spatial experience is shaped by the interrelation of material, social, and time-related aspects. However, the chosen concept results in a different experience throughout patients’ journey. Conclusions: Based on an analysis of the different journeys, we conclude that patients’ interpretation of a hospital’s care vision is influenced not only by what the hospital communicates explicitly or how it educates its staff but also by what is implicitly told by the built environment.
Evaluation of ethnic disparities in detection of depression and anxiety in primary care during the maternal period: Combined analysis of routine and cohort data
Authors: Prady Stephanie L. , Pickett Kate E. , Petherick Emily S. , Gilbody Simon , Croudace Tim , Mason Dan , Sheldon Trevor A. , Wright John 
Published: January 2016

BackgroundThere are limited data on detection disparities of common mental disorders in minority ethnic women.AimsDescribe the natural history of common mental disorders in primary care in the maternal period, characterise women with, and explore ethnic disparities in, detected and potentially missed common mental disorders.MethodSecondary analyses of linked birth cohort and primary care data involving 8991 (39.4% White British) women in Bradford. Common mental disorders were characterised through indications in the electronic medical record. Potentially missed common mental disorders were defined as an elevated General Health Questionnaire (GHQ-28) score during pregnancy with no corresponding common mental disorder markers in the medical record.ResultsEstimated prevalence of pre-birth common mental disorders was 9.5%, rising to 14.0% 3 years postnatally. Up to half of cases were potentially missed. Compared with White British women, minority ethnic women were twice as likely to have potentially missed common mental disorders and half as likely to have a marker of screening for common mental disorders.ConclusionsCommon mental disorder detection disparities exist for minority ethnic women in the maternal period.
Lung Cancer Survival Among Chinese Americans, 2000 to 2010
Authors: Gomez Scarlett Lin , Yang Juan , Lin Shih-Wen , McCusker Margaret , Sandler Alan , Patel Manali , Cheng Iona , Wakelee Heather A. , Clarke Christina A. 
Published: January 2016

Purpose Despite being the leading cause of cancer death, no prior studies have characterized survival patterns among Chinese Americans diagnosed with lung cancer. This study was conducted to identify factors associated with survival after lung cancer in a contemporary cohort of Chinese patients with lung cancer. Methods The study design is a prospective descriptive analysis of population-based California Cancer Registry data. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HRs) for overall mortality. Participants were Chinese American residents diagnosed with first primary invasive lung cancer from 2000 to 2010 (2,216 men and 1,616 women). Results Among Chinese men, decreased mortality was associated with care at a National Cancer Institute cancer center (HR, 0.85; 95% CI, 0.73 to 0.99) and adenocarcinoma versus small-cell carcinoma (HR, 0.78; 95% CI, 0.65 to 0.92). Women had better survival compared with men (HR, 0.82; 95% CI, 0.75 to 0.89), with mortality associated with never married versus currently married status (HR, 1.36; 95% CI, 1.11 to 1.66), lower versus higher neighborhood socioeconomic status (HR, 1.38; 95% CI, 1.10 to 1.72 comparing lowest to highest quintile), care at a cancer center (HR, 0.80; 95% CI, 0.67 to 0.96), and squamous cell relative to small-cell carcinoma (HR, 1.60; 95% CI, 1.04 to 2.48). Conclusion Focusing on factors associated with marital status, community socioeconomic status, and characteristics unique to National Cancer Institute–designated cancer centers may help to identify potential strategies for improving the length of survival for Chinese Americans.
Les enjeux de la traduction sous la Révolution française. La transmission des textes du républicanisme anglais
Authors: Monnier Raymonde 
Published: January 2016

<p>L’étude des traductions est essentielle pour éclairer la généalogie de la transmission des idées et des théories politiques. L’article tente de comprendre les enjeux politiques et stratégiques de la traduction sous la Révolution française, notamment celle des textes républicains de la première révolution anglaise. Quand et pourquoi les concepts développés en leur temps par les théoriciens du Commonwealth prennent-ils une nouvelle actualité en 1789? Comment et dans quelles circonstances les traducteurs se réapproprientils ces textes pour agir sur le cours des choses? Le but est de dépasser l’analyse en termes de transfert et d’influence d’une tradition pour s’intéresser au contexte de réception, à l’agenda politique des traducteurs et à l’épreuve de la traduction dans un état donné de la langue. Comment ces textes s’insèrent-t-ils dans le contexte intellectuel et les conventions argumentatives du moment? Dans quelle mesure ces traductions ont-elles été des outils de l’innovation politique?</p>