bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potential Mechanisms of Interstitial Lung Disease Induced by Antibody–Drug Conjugates Based on Quantitative Analysis of Drug Distribution
Authors: Koganemaru Shigehiro , Fuchigami Hirobumi , Morizono Chihiro , Shinohara Hiroko , Kuboki Yasutoshi , Furuuchi Keiji , Uenaka Toshimitsu , Doi Toshihiko , Yasunaga Masahiro 
Published: October 2024

Abstract
Antibody–drug conjugates (ADC) are a rapidly advancing category of therapeutic agents with notable anticancer efficacy. However, the emergence of interstitial lung disease as a severe ADC-associated adverse event highlights the need to better understand the underlying mechanisms. In this study, xenograft model mice with tumors expressing different levels of the trophoblast antigen 2 (TROP2) were generated by subcutaneously transplanting the various TROP2-expressing cancer lines. The mice received different doses of TROP2–eribulin, a novel TROP2-targeting ADC, composed of an anti-TROP2 antibody and the eribulin payload, joined by a cleavable linker. The concentration and distribution of TROP2–eribulin, as well as the pharmacokinetics of eribulin release, were assessed in tumor and lung tissues. Analysis of tumor tissue showed that the concentration of released eribulin was approximately 10-fold higher in NCI-H2110 (high TROP2 expression) than in A549 (low TROP2 expression), whereas analysis of lung tissue showed that TROP2–eribulin was distributed in lung tissue in a dose-dependent manner, regardless of TROP2 expression, with significantly more eribulin released in the high-dose group than in the other dose groups (P &lt; 0.05). Immunofluorescence assay analysis showed that TROP2–eribulin localized to alveolar macrophages. In the analysis using human leukemia monocytic cell, the concentration of eribulin released from TROP2–eribulin was significantly reduced by the use of an Fc receptor inhibitor (P &lt; 0.05). These results revealed that Fcγ receptor–mediated uptake by alveolar macrophages releases the cytotoxic payload into lung tissue, helping to clarify the pathogenesis of ADC-induced interstitial lung disease.
Automated Breast Density Assessment for Full-Field Digital Mammography and Digital Breast Tomosynthesis
Authors: Jiang Shu , Bennett Debbie L. , Chen Simin , Toriola Adetunji T. , Colditz Graham A. 
Published: October 2024

Abstract
Mammographic density is a strong risk factor for breast cancer and is reported clinically as part of Breast Imaging Reporting and Data System (BI-RADS) results issued by radiologists. Automated assessment of density is needed that can be used for both full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) as both types of exams are acquired in standard clinical practice. We trained a deep learning model to automate the estimation of BI-RADS density from a prospective Washington University clinic-based cohort of 9,714 women, entering into the cohort in 2013 with follow-up through October 31, 2020. The cohort included 27% non-Hispanic Black women. The trained algorithm was assessed in an external validation cohort that included 18,360 women screened at Emory from January 1, 2013, and followed up through December 31, 2020, that included 42% non-Hispanic Black women. Our model-estimated BI-RADS density demonstrated substantial agreement with the density as assessed by radiologists. In the external validation, the agreement with radiologists for category B 81% and C 77% for FFDM and B 83% and C 74% for DBT shows important distinction for separation of women with dense breast. We obtained a Cohen’s κ of 0.72 (95% confidence interval, 0.71–0.73) in FFDM and 0.71 (95% confidence interval, 0.69–0.73) in DBT. We provided a consistent and fully automated BI-RADS estimation for both FFDM and DBT using a deep learning model. The software can be easily implemented anywhere for clinical use and risk prediction.
Prevention Relevance: The proposed model can reduce interobserver variability in BI-RADS density assessment, thereby providing more standard and consistent density assessment for use in decisions about supplemental screening and risk assessment.
Self-Guided Blood Pressure Screening in the Community: Opportunities, and Challenges
Authors: O’Hagan Edel T. , Marschner Simone L. , Mishra Shiva , Min Haeri , Schutte Aletta E. , Schlaich Markus P. , Hannebery Patrick , Duncan Noel , Shaw Tim , Chow Clara K. 
Published: October 2024

BACKGROUND:
Community-based health check kiosks provide opportunities to improve the detection and long-term monitoring of hypertension. We describe the sociodemographic and cardiovascular characteristics of first-time and repeat users of these kiosks.

METHOD:
This was an observational study. Deidentified data collected from 430 SiSU Health consumer-facing health check stations in pharmacies across Australia between January 2018 and November 2020 were analyzed. Using a logistic regression, we identified factors associated with repeat checks in the overall cohort and in those with possible hypertension presented as adjusted odds ratios (aOR) and 95% CIs.

RESULTS:
A total of 982 122 unique checks were conducted; 54% (n=530 139) of the health check users were female, and the average age of all users was 38.2 (SD 16.0) years. Of those that used the kiosks, 13% used them more than once. Overall, 22% met the definition of possible hypertension, 16% (n=136 345) had blood pressure (BP) ≥140/90 mm Hg, 4% (n=34 349) had BP >160/100 mm Hg, and 13% (121 282) reported taking BP medicines. In the adjusted analysis, first-time users who were aged 50 to 69 years (aOR 0.91 [95% CI 0.87–0.96]) or ≥70 years (aOR 0.68 [95% CI 0.62–0.74]) were less likely than young users (18–29 years) to return for a second health check. Those in very remote areas were 61% (aOR 0.39 [95% CI 0.19–0.72]), and smokers were 13% less likely to return (aOR 0.87 [95% CI 0.83–0.91]). People taking BP medications were more likely to return (aOR 1.16 [95% CI 1.09–1.22]).

CONCLUSIONS:
Community-based health checks may identify people with high BP and could provide an option for self-monitoring. Broader implementation is needed to increase the reach in rural areas and among the elderly population.
Piezo1‐Mediated Mechanotransduction Contributes to Disturbed Flow‐Induced Atherosclerotic Endothelial Inflammation
Authors: Lan Yining , Lu Jing , Zhang Shaohan , Jie Chunxiao , Chen Chunyong , Xiao Chao , Qin Chao , Cheng Daobin 
Published: October 2024

Background
Disturbed flow generates oscillatory shear stress (OSS), which in turn leads to endothelial inflammation and atherosclerosis. Piezo1, a biomechanical force sensor, plays a crucial role in the cardiovascular system. However, the specific role of Piezo1 in atherosclerosis remains to be fully elucidated.

Methods and Results

We detected the expression of Piezo1 in atherosclerotic mice and endothelial cells from regions with disturbed blood flow. The pharmacological inhibitor Piezo1 inhibitor (GsMTx4) was used to evaluate the impact of Piezo1 on plaque progression and endothelial inflammation. We examined Piezo1's direct response to OSS in vitro and its effects on endothelial inflammation. Furthermore, mechanistic studies were conducted to explore the potential molecular cascade through which Piezo1 mediates endothelial inflammation in response to OSS. Our findings revealed the upregulation of Piezo1 in apoE−/− (apolipoprotein E) atherosclerotic mice, which is associated with disturbed flow. Treatment with GsMTx4 not only delayed plaque progression but also mitigated endothelial inflammation in both chronic and disturbed flow‐induced atherosclerosis. Piezo1 was shown to facilitate calcium ions (Ca
2
+
) influx in response to OSS, thereby activating endothelial inflammation. This inflammatory response was attenuated in the absence of Piezo1. Additionally, we identified that under OSS, Piezo1 activates the Ca
2
+
/CaM/CaMKII (calmodulin/calmodulin‐dependent protein kinases Ⅱ) pathways, which subsequently stimulate downstream kinases FAK (focal adhesion kinase) and Src. This leads to the activation of the OSS‐sensitive YAP (yes‐associated protein), ultimately triggering endothelial inflammation.

Conclusions

Our study highlights the key role of Piezo1 in atherosclerotic endothelial inflammation, proposing the Piezo1–Ca
2+
/CaM/CaMKII‐FAK/Src‐YAP axis as a previously unknown endothelial mechanotransduction pathway. Piezo1 is expected to become a potential therapeutic target for atherosclerosis and cardiovascular diseases.
Impact of Daily Lower‐Body Negative Pressure or Cycling Followed by Venous Constrictive Thigh Cuffs on Bedrest‐Induced Orthostatic Intolerance
Authors: Hönemann Jan‐Niklas , Hoffmann Fabian , de Boni Laura , Gauger Peter , Mulder Edwin , Möstl Stefan , Heusser Karsten , Schmitz Marie‐Therese , Halbach Marcel , Laurie Steven S. , Lee Stuart M. C. , Macias Brandon R. , Jordan Jens , Tank Jens 
Published: October 2024

Background
Orthostatic intolerance occurs following immobilization in patients on Earth and in astronauts after spaceflight. Head‐down tilt bedrest is a terrestrial model for weightlessness and induces orthostatic intolerance. We hypothesized that lower‐body negative pressure (LBNP) or cycling followed by wearing venous constrictive thigh cuffs mitigates orthostatic intolerance after head‐down tilt bedrest.

Methods and Results

We enrolled 47 healthy individuals (20 women, 35±9 years) to a 30‐day strict head‐down tilt bedrest study. During bedrest, they were assigned to 6 hours of 25 mm Hg LBNP (n=12) per day and 1 hour of supine cycling followed by 6 hours of venous constriction through thigh cuffs 6 days per week (n=12), 6 hours of daily upright sitting (positive control, n=11), or no countermeasure (negative control, n=12). We measured orthostatic tolerance as the time to presyncope during 80° head‐up tilt testing with incremental LBNP before and immediately after bedrest. We determined plasma volume with carbon monoxide rebreathing before and at the end of bedrest. After bedrest, orthostatic tolerance decreased 540±457 seconds in the control group, 539±68 seconds in the cycling group, 217±379 seconds in the LBNP group, and 289±89 seconds in the seated group (
P
<0.0001 time point,
P
=0.009 for group differences). Supine and upright heart rate increased in all groups following bedrest. Plasma volume was only maintained in the cycling group but decreased in all others (interaction countermeasure×time point
P
<0.0001).

Conclusions
Six hours of moderate LBNP training was as effective as sitting in attenuating orthostatic intolerance after 30 days of head‐down tilt bedrest. Daily cycling exercise followed by 6 hours of wearing venous constrictive thigh cuffs, while maintaining plasma volume, did not improve orthostatic tolerance.

Registration

URL:
https://www.bfarm.de/EN
; Identifiers: DRKS00027643 and DRKS00030848.
Peripartum Cardiomyopathy and Social Vulnerability: An Epidemiological Analysis of Mortality Outcomes
Authors: Shahid Mahek , Ibrahim Ramzi , Ulhaque Tazeen , Nhat Hoang , Sainbayar Enkhtsogt , Lee Kwan , Mamas Mamas A. 
Published: October 2024

Background
Peripartum cardiomyopathy (PPCM) outcomes have been previously linked to demographic and social factors. The social vulnerability index (SVI) is a measure of social vulnerability in the United States. We explored PPCM disparities and the impact of SVI on PPCM mortality.

Methods and Results
Mortality from 1999 to 2020, SVI, and demographic data were obtained from CDC databases. County‐specific SVI rankings were linked to PPCM age‐adjusted mortality rates (AAMRs), allowing for a comparative analysis of AAMRs across both cumulative populations and subpopulations to identify disparities. All US counties were then stratified into low‐ and high‐SVI groups, facilitating comparison of SVI rankings by estimation of excess‐deaths per 1 000 000 person‐years attributable to greater social vulnerability and rate ratios (RR) through univariable Poisson regression. We identified a total of 1026 deaths related to PPCM between 1999 and 2020. Overall AAMR increased from 0.180 in 1999 to 0.326 in 2020. Black populations (AAMR: 1.081) and Southern US counties (AAMR: 0.444) had the highest AAMRs compared with other racial and US census groups, respectively. Higher SVI accounted for 0.172 excess deaths per 1 000 000 person‐years (RR=1.800). Among Black and White populations, higher SVI also accounted for 0.248 and 0.071 excess deaths per 1 000 000 person‐years, respectively. Similar impacts of greater social vulnerability were observed when comparing the US census regions (Northeast RR=1.609, Midwest RR=1.819, South RR=1.934, West RR=1.776).

Conclusions
PPCM mortality disparities exist across racial and geographic populations in the United States. A greater burden of social vulnerability is associated with higher PPCM mortality on a national level.
Is Oration Literature?
Authors: Qutbuddin Tahera 
Published: October 2024

Abstract
Is oration literature? More specifically, can we read the multi-functional Arabic oration (khuṭbah) of the 1st/7th and 2nd/8th centuries as part of the classical prose canon? In this article, I argue that if our definition of literature includes beautiful language, admiration expressed by literary theorists, and masterful articulation of themes to evoke audience response, early Arabic oration is most certainly literature. I demonstrate this claim by analyzing the rhythmic and graphic oral aesthetics of early Arabic oration, the views of medieval theorists regarding its distinguished place and literary nature, and its crucial influence on the development of the chancery epistle (risālah), the first written genre of Arabic literary prose. I contend that khuṭbah is the foundational prose genre of Arabic and it has materially influenced the major genres of risālah and maqāmāt that followed. The history of Arabic literature cannot be written without oration.
Usage of al-shayb wa-l-shabāb in Ibn Ḥamdīs’s ḥāʾiyyah ‘Ṭaraqat wa-l-laylu’
Authors: Carpentieri Nicola 
Published: October 2024

Abstract
This article examines Ibn Ḥamdīs’s ḥāʾiyyah ‘Ṭaraqat wa-l-laylu’, a multi-partite ode of thirty-four lines. I argue that the poet’s deployment of the motif of old age vs. youth (al-shayb wa-l-shabāb) within this qaṣīdah responds to a codified “poetics of old age” that sought to enhance the poem’s semantic layering. Ibn Ḥamdīs adheres to a normative aesthetics of Arabic old-age poetry, obtaining an effect that I refer to as “thematic displacement.” In support of my argument, I quote an excerpt of al-Sharīf al-Murtaḍā’s introduction to his anthology al-Shihāb fī-l-shayb wa-l-shabāb, which reveals how the critic prized Arabic verse on old age precisely because of its capacity to interact dialogically with the traditional maʿānī al-shiʿr. The article includes a revised biography of Ibn Ḥamdīs and a new English translation of the poem.
The Writer Sweating at His Desk: Labor and Literature in Fatḥī Ghānim’s al-Jabal
Authors: Alon Shir 
Published: October 2024

Abstract
Debates about the role of literature in postcolonial Egypt took place within a broader discourse on the mobilization of labor and the creation of a national productive economy. Reading the archive of early issues of the pioneering journal Al-Ghad, this article shows that Egyptian progressive writers in the early 1950s strove to define themselves as workers and literature as a productive endeavor. The article then turns to Fatḥī Ghānim’s 1957 novel al-Jabal, arguing that its depiction of a failed peasant reform project is a means of reflecting on the work of the writer and its productive ends. While nominally committed to a progressive ethos of productivity, the novel remains haunted by the specter of labor with no product, exertion that produces nothing, which endures as an alternative model for literary writing.
Mapping Muslim Chaplaincy
Authors: Gilliat-Ray Sophie , Schmid Hansjörg , Ali Mansur 
Published: October 2024

Abstract
This article analyses the emergent field of Muslim chaplaincy research by reviewing English-language publications in this growing area of professional religious work, especially in Europe and the United States. After presenting the method of our enquiry, we provide a quantitative and qualitative analysis of the literature reviewed. We then focus on three key topics in Muslim Chaplaincy Studies that derive from our quantitative and qualitative research. These are: the training of Muslim chaplains, which is strongly linked to professionalisation, the vocabulary and sources that underpin Muslim chaplaincy and, finally, the significance of the increasing involvement of Muslim women in this area of professional religious work and leadership. Having identified exactly 100 publications related to the development of Muslim chaplaincy, many of them arising from empirical research, serious practitioner reflections located in peer-review publications, and a small number of articles that are explicitly devoted to methodological considerations, we are suggesting in this article that a distinctive sub-field of Muslim Chaplaincy Studies can now be identified.
Impacts of black soldier fly, Hermetia illucens, larval frass on the emergence and seedling vigor of three vegetable crop species
Authors: Chavez M.Y. , Uchanski M. , Tomberlin J.K. 
Published: October 2024

Abstract
The waste material from rearing black soldier fly, Hermetia illucens (L.), (Diptera: Stratiomyidae), larvae (BSFL), frass, could serve as a partial replacement for fertilizer or growing media, such as peat. Studies have shown that depending on the crop life cycle, long or short, the incorporation of frass can have positive impacts on vegetable growth. Investigating the earlier stages of growth, such as emergence, can provide more information on the acute impacts of insect frass on plant production. Two greenhouse studies were designed to investigate the use of frass in vegetable production at the seedling stage: BSFL frass as a partial replacement for peat in a growth germination medium and BSFL frass as a fertility replacement in a growth germination medium. Tomato, lettuce, and arugula seeds were grown in a standard control growing media, a growing media amended with frass to partially replace peat, and a growing media with frass applications to substitute the fertility source. In all treatments and varieties, the control growing media produced better or comparable results to the treatments. As a peat replacement, the two tomato varieties, lettuce, and arugula seedlings grown in frass had comparable seedling vigour and days to emergence to those grown in the control. As a fertility replacement, seedlings grown in frass had significantly lower percent emergence in all four cultivars when compared to the control. The tomato varieties also had significantly lower seedling vigour in the BSFL fertility treatments than the control. Depending on crop and growing media composition, the impacts of frass on early plant development vary. The adoption of frass into growing practices should include preliminary tests for nutrient composition and microbial contamination.
Psychometric Properties of the Hungarian Passion Scale-8 (PS-8-HU) in Physically Active and Inactive Adults
Authors: Árok Pálma , Morvay-Sey Kata , Vujić Aleksandar , Szabo Attila 
Published: October 2024

The 8-item Passion Scale (PS-8) is a unidimensional instrument used in dual versus single passion research. The PS-8 was validated in Icelandic, Persian, and Turkish student samples. In this study, we translated the PS-8 and validated it with physically active and inactive adults from Hungary. We also evaluated measurement invariance (across gender, physical activity, exercise frequency, and age groups) of the Hungarian version of the Passion scale (PS-8-HU). Data were collected online between fall 2023 and winter 2024, including a test and retest phase. The sample comprised 729 Hungarian physically active and inactive adults (68% females, 32% males; ages 18–78 years), of whom 196 participated in the retest. We used confirmatory factor analysis (CFA), item analysis, correlations, t-test and ANOVA in checking the scale’s validity and reliability, and we used a multigroup CFA to test the measurement invariance. The results supperted a univariate structure of the PS-8-HU. The instrument was invariant for gender (at the strict level), exercise frequency (metric), physical activity (metric), and age (scalar). The internal reliability of the PS-8-HU was .93 and test-retest reliability was .77. The PS-8-HU also exhibited good concurrent and construct validities, high homogeneity, and adequate discriminant validity.
Steps Toward Decreasing Maternal Alcohol Consumption in Israel: Nationwide Trends During a Decade
Authors: Senecky Yehuda , Zrubavel Yaaron Noam , Chodick Gabriel , Berger Andrea , Hen-Herbst Liat , Fund Ilana Barta , Massalha Manal , Matot Ran , Ganelin-Cohen Esther 
Published: October 2024

Objectives: Prenatal alcohol exposure poses a substantial risk to fetal development. Efforts were made in 2011-2020 to increase public awareness of and prevent alcohol consumption during pregnancy. We conducted a cross-sectional survey in Israel of pregnant women’s alcohol consumption from January 2021 through June 2023 and compared our results with the results of a survey conducted during 2009-2010 to assess changes over time. Methods: We conducted cross-sectional surveys at 3 public hospitals in central and northern Israel. Surveyors visited hospitals twice weekly and used a questionnaire consistent with one used in 2009-2010 that focused on alcohol consumption 3 months before pregnancy and during pregnancy. We conducted a stratified analysis of the prevalence of alcohol consumption during pregnancy by demographic characteristics. We also used a multivariable logistic regression model to examine variables associated with receiving guidance on alcohol consumption during pregnancy. Results: Of 1915 women in the 2021-2023 survey (mean [SD] age, 30.8 [5.6] y), 1204 (62.9%) reported never consuming alcohol before pregnancy and 1708 (89.2%) reported no alcohol consumption during pregnancy. During pregnancy, 157 (8.2%) women reported consuming alcohol weekly or less, 12 (0.6%) more frequently, and 52 (2.7%) binge drinking. We found a significant decrease in alcohol consumption during pregnancy in 2021-2023 as compared with 2009-2010 (odds ratio, 0.68; 95% CI, 0.52-0.88; P = .03). Predictors of alcohol consumption during pregnancy included alcohol consumption before pregnancy, parity, and smoking. Significantly more women in the 2021-2023 sample (n = 569; 29.7%) than in the 2009-2010 sample received guidance on alcohol consumption during pregnancy ( P < .001). Conclusions: Educational efforts should continue to increase awareness of the risks of prenatal alcohol exposure in the general population and among health professionals.