bluuebunny/crossref_metadata_2025_split huggingface dataset:
Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus
Authors: Park Pojeong , Sanderson Thomas M. , Amici Mascia , Choi Sun-Lim , Bortolotto Zuner A. , Zhuo Min , Kaang Bong-Kiun , Collingridge Graham L. 
Published: January 2016

Two forms of NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) at hippocampal CA1 synapses can be distinguished based on their sensitivity to inhibitors of protein kinase A (PKA). The PKA-dependent form requires multiple episodes of high-frequency stimulation (HFS) or theta burst stimuli (TBS) with a spacing between episodes in the order of minutes. To investigate the mechanism by which spaced episodes induce the PKA-dependent form of LTP, we have compared, in interleaved experiments, spaced (s) and compressed (c) TBS protocols in the rat CA1 synapses. We find that LTP induced by sTBS, but not that induced by cTBS, involves the insertion of calcium-permeable (CP) AMPARs, as assessed using pharmacological and electrophysiological criteria. Furthermore, a single TBS when paired with rolipram [4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one], to activate PKA, generates an LTP that also involves the insertion of CP-AMPARs. These data demonstrate that the involvement of CP-AMPARs in LTP is critically determined by the timing of the induction trigger and is associated specifically with the PKA-dependent form of LTP.SIGNIFICANCE STATEMENTLong-term potentiation is a family of synaptic mechanisms that are believed to be important for learning and memory. Two of the most extensively studied forms are triggered by the synaptic activation of NMDA receptors and expressed by changes in AMPA receptor function. They can be distinguished on the basis of their requirement for activation of a protein kinase, PKA. We show that the PKA-dependent form also involves the transient insertion of calcium-permeable AMPA receptors. These results have implications for relating synaptic plasticity to learning and memory and suggest a specific linkage between PKA activation and the rapid synaptic insertion of calcium-permeable AMPA receptors during long-term potentiation.
Transitions between Multiband Oscillatory Patterns Characterize Memory-Guided Perceptual Decisions in Prefrontal Circuits
Authors: Wimmer Klaus , Ramon Marc , Pasternak Tatiana , Compte Albert 
Published: January 2016

Neuronal activity in the lateral prefrontal cortex (LPFC) reflects the structure and cognitive demands of memory-guided sensory discrimination tasks. However, we still do not know how neuronal activity articulates in network states involved in perceiving, remembering, and comparing sensory information during such tasks. Oscillations in local field potentials (LFPs) provide fingerprints of such network dynamics. Here, we examined LFPs recorded from LPFC of macaques while they compared the directions or the speeds of two moving random-dot patterns, S1 and S2, separated by a delay. LFP activity in the theta, beta, and gamma bands tracked consecutive components of the task. In response to motion stimuli, LFP theta and gamma power increased, and beta power decreased, but showed only weak motion selectivity. In the delay, LFP beta power modulation anticipated the onset of S2 and encoded the task-relevant S1 feature, suggesting network dynamics associated with memory maintenance. After S2 onset the difference between the current stimulus S2 and the remembered S1 was strongly reflected in broadband LFP activity, with an early sensory-related component proportional to stimulus difference and a later choice-related component reflecting the behavioral decision buildup. Our results demonstrate that individual LFP bands reflect both sensory and cognitive processes engaged independently during different stages of the task. This activation pattern suggests that during elementary cognitive tasks, the prefrontal network transitions dynamically between states and that these transitions are characterized by the conjunction of LFP rhythms rather than by single LFP bands.SIGNIFICANCE STATEMENTNeurons in the brain communicate through electrical impulses and coordinate this activity in ensembles that pulsate rhythmically, very much like musical instruments in an orchestra. These rhythms change with “brain state,” from sleep to waking, but also signal with different oscillation frequencies rapid changes between sensory and cognitive processing. Here, we studied rhythmic electrical activity in the monkey prefrontal cortex, an area implicated in working memory, decision making, and executive control. Monkeys had to identify and remember a visual motion pattern and compare it to a second pattern. We found orderly transitions between rhythmic activity where the same frequency channels were active in all ongoing prefrontal computations. This supports prefrontal circuit dynamics that transitions rapidly between complex rhythmic patterns during structured cognitive tasks.
Natural course of congenital hypothyroidism by dual oxidase 2 mutations from the neonatal period through puberty
Authors: Maruo Yoshihiro , Nagasaki Keisuke , Matsui Katsuyuki , Mimura Yu , Mori Asami , Fukami Maki , Takeuchi Yoshihiro 
Published: January 2016

AimWe previously reported that biallelic mutations in dual oxidase 2 (DUOX2) cause transient hypothyroidism. Since then, many cases with DUOX2 mutations have been reported. However, the clinical features and prognosis of individuals with DUOX2 defects have not been clarified.ObjectiveWe investigated the prognosis of patients with congenital hypothyroidism (CH) due to DUOX2 mutations.PatientsTwenty-five patients were identified by a neonatal screening program and included seven familial cases. Their serum TSH values ranged from 18.9 to 734.6 mU/l. Twenty-two of the patients had low serum free thyroxine (fT4) levels (0.17–1.1 ng/dl). Twenty-four of the patients were treated with L-thyroxine.MethodsWe analyzed the DUOX2, thyroid peroxidase, Na+/I− symporter, and dual oxidase maturation factor 2 genes of these 25 patients by PCR-amplified direct sequencing. An additional 11 genes were analyzed in 11 of the 25 patients using next-generation sequencing.ResultsAll patients had biallelic DUOX2 mutations, and seven novel alleles were detected. Fourteen of the patients were able to discontinue replacement therapy, and seven were receiving reduced L-thyroxine doses. Normalization of thyroglobulin lagged several years behind the completion of treatment. Two patients showed permanent hypothyroidism. Except for one case of a learning disability, growth and psychomotor development were normal.ConclusionThe prognosis of Japanese patients with DUOX2 defects was usually transient CH. Delayed improvement of thyroglobulin indicates that these patients have subclinical hypothyroidism. Hypothyroidism did not recur in patients during the study period (up to 18 years old).
Polycystic ovary syndrome is associated with increased osteopontin levels
Authors: Saklamaz Ali , Calan Mehmet , Yilmaz Ozgur , Kume Tuncay , Temur Muzaffer , Yildiz Nurdan , Kasap Esin , Genc Mine , Sarer Yurekli Banu , Unal Kocabas Gokcen 
Published: January 2016

ObjectiveOsteopontin (OPN) is a multi-functional secreted glycoprotein that plays a crucial role in glucose metabolism and inflammatory process. Growing evidence suggests that there is a link between OPN and ovarian function. However, no such link has yet been found for OPN in polycystic ovary syndrome (PCOS). Our aim was to ascertain whether circulating OPN levels are altered in women with PCOS and to determine whether OPN levels differ between the follicular phase and mid-cycle of the menstrual cycle in eumenorrheic women.Design and methodsIn total, 150 women with PCOS and 150 age- and BMI-matched controls without PCOS were recruited for this prospective observational study. OPN levels were measured using ELISA. Metabolic parameters were also determined.ResultsCirculating OPN levels were significantly elevated in PCOS women compared with controls (69.12±31.59 ng/ml vs 42.66±21.28 ng/ml; P<0.001). OPN levels were significantly higher at mid-cycle than in the follicular phase in eumenorrheic women. OPN was positively correlated with BMI, homeostasis model assessment of insulin resistance (HOMA-IR), free testosterone, and high sensitivity C-reactive protein (hs-CRP). Multivariate logistic regression analyses revealed that the odds ratio (OR) for PCOS was 3.64 for patients in the highest quartile of OPN compared with those in the lowest quartile (OR=3.64; 95% CI=2.42–5.57; P=0.011). Our findings indicate that BMI, HOMA-IR, hs-CRP, and free testosterone are independent factors influencing serum OPN levels and that OPN is an independent predictor for HOMA-IR.ConclusionPCOS is associated with increased OPN levels.
Association of antiepileptic drug usage, trace elements and thyroid hormone status
Authors: Zevenbergen Chantal , Korevaar Tim I M , Schuette Andrea , Peeters Robin P , Medici Marco , Visser Theo J , Schomburg Lutz , Visser W Edward 
Published: January 2016

BackgroundLevels of thyroid hormone (TH) and trace elements (copper (Cu) and selenium (Se)) are important for development and function of the brain. Anti-epileptic drugs (AEDs) can influence serum TH and trace element levels. As the relationship between AEDs, THs, and trace elements has not yet been studied directly, we explored these interactions.MethodIn total 898 participants, from the Thyroid Origin of Psychomotor Retardation study designed to investigate thyroid parameters in subjects with intellectual disability (ID), had data available on serum Se, Cu, thyroid stimulating hormone (TSH), free thyroxine (FT4), tri-iodothyronine (T3), reverse T3, T4, and thyroxine-binding globulin (TBG); 401 subjects were on AED treatment. Differences in trace elements according to medication usage was investigated using ANOVA, and associations between trace elements and thyroid parameters were analysed using (non-) linear regression models.ResultsStudy participants were not deficient in any of the trace elements analyzed. AED (carbamazepine, valproate and phenytoin) usage was negatively associated with serum Se and showed compound-specific associations with Cu levels. After correction for drug usage, Se was positively associated with TSH levels, negatively associated with FT4levels, and positively with T3levels. Cu was positively associated with T4, T3, and rT3, which was largely dependent on TBG levels.ConclusionThe subjects with ID did not display profound deficiencies in trace element levels. AEDs were associated with serum Se and Cu levels, while serum Se and Cu were also associated with thyroid parameters. Further studies on the underlying mechanisms and potential clinical importance are warranted.
A Multidisciplinary Children’s Airway Center: Impact on the Care of Patients With Tracheostomy
Authors: Abode Kathleen A. , Drake Amelia F. , Zdanski Carlton J. , Retsch-Bogart George Z. , Gee Amanda B. , Noah Terry L. 
Published: January 2016

BACKGROUND:Children with complex airway problems see multiple specialists. To improve outcomes and coordinate care, we developed a multidisciplinary Children’s Airway Center. For children with tracheostomies, aspects of care targeted for improvement included optimizing initial hospital discharge, promoting effective communication between providers and caregivers, and avoiding tracheostomy complications.METHODS:The population includes children up to 21 years old with tracheostomies. The airway center team includes providers from pediatric pulmonology, pediatric otolaryngology/head and neck surgery, and pediatric gastroenterology. Improvement initiatives included enhanced educational strategies, weekly care conferences, institutional consensus guidelines and care plans, personalized clinic schedules, and standardized intervals between airway examinations. A patient database allowed for tracking outcomes over time.RESULTS:We initially identified 173 airway center patients including 123 with tracheostomies. The median number of new patients evaluated by the center team each year was 172. Median hospitalization after tracheostomy decreased from 37 days to 26 days for new tracheostomy patients &lt;1 year old discharged from the hospital. A median of 24 care plans was evaluated at weekly conferences. Consensus protocol adherence increased likelihood of successful decannulation from 68% to 86% of attempts. The median interval of 8 months between airway examinations aligned with published recommendations.CONCLUSIONS:For children with tracheostomies, our Children’s Airway Center met and sustained goals of optimizing hospitalization, promoting communication, and avoiding tracheostomy complications by initiating targeted improvements in a multidisciplinary team setting. A multidisciplinary approach to management of these patients can yield measurable improvements in important outcomes.
A Study on Knowledge Management Capabilities towards New Product Innovation Type and Development Performance of Chinese Businesses
Authors: Xu Sheng 
Published: January 2016

A business needs to constantly innovate and reinforce the competitiveness for the survival development and sustainable management. Focus on new product development has become the key factor in modern manufacturers maintaining the competitiveness. The process and the results depend on the effective application and management of organizational knowledge that it is necessary to reinforce the capabilities in order to promote the new product development performance.
With random sampling, the employees and the managers in top ten businesses of 1,000 Chinese industrial businesses are distributed 1,000 copies of questionnaire. Total 568 effective copies are retrieved, with the retrieval rate 57%. The results show 1. the significantly positive correlation between knowledge acquisition capabilities in knowledge management capabilities and new product development performance, 2. the remarkably positive correlation between knowledge transformation and application capabilities in knowledge management capabilities and new product development performance, 3. the notably positive correlation between knowledge protection capabilities in knowledge management capabilities and new product development performance, and 4. the signifi- cant moderating effects of product innovation type on the correlation between knowledge management capabilities and new product development performance. The research results are expected to provide essential contributions and suggestions for the knowledge management capabilities and the new product development of Chinese businesses.
Effects of Curriculum Design on Students’ Creative Potential Developing — A Case Study on Students in the Department of Business Management
Authors: Lin Pao-Cheng , Lin Pei-Kuan 
Published: January 2016

The rapid advance of science technology and civilization has resulted in people’s activities being more complicated as various new problems are likely to occur at any time. Problem-solving abilities therefore become a basic competence to survive in modern societies. In the problem-solving process, the development of creativity is required to break through dilemmas. School education aims to cultivate students’ decision-making and problem-solving competence. Nonetheless, the educational approaches and contents in Taiwan stress too much on mastery learning, and ignore the development of curiosity and creative potential.
Aiming at the students in the department of business management in national universities in Taiwan, total 300 copies of questionnaires are distributed, and 187 valid copies are retrieved, with the retrieval rate 62%, in which each retrieved copy is regarded as a valid sample. The research findings show that Curriculum Design presents partially positive effects on Fluency, Flexibility, Originality, and Elaboration in Creative Potential Developing and Background Variables reveal significant moderating effects on the correlations between Curriculum Design and Creative Potential Developing.
A Study on the Correlations among Organizational Support, Professional Commitment, and Employee Engagement in Catering Industry
Authors: Lo Chun-Hsien , Nieh Fang-Pei 
Published: January 2016

The gross product of catering industry in developed countries often exceeds most other industries because of changing styles of societies, economic development, increasing national income, frequent international trade, and convenient and rapid transportation. The economic development in Taiwan has stepped in service-oriented phase from industrial economy and is approaching the mature economy of advanced countries. The marketing and management strategies for catering industry have become important as it is a business related to “people”, with more personnel than other industries, mainly providing delicate food, which is regarded as the key in tourism industry, and offering better products and services for customers.
Aiming at the staffin Landis Hotels & Resorts as the research subject, total 280 copies of questionnaires are distributed, and 176 valid copies are retrieved, with the retrieval rate 63%. The research findings show the significant correlations between 1. Organizational Support and Professional Commitment, 2. Professional Commitment and Employee Engagement, and 3. Organizational Support and Employee Engagement.
Effects of Crisis Communication Strategies and Media Report on Corporate Image in Catering Industry
Authors: Gunawan Sri , Shieh Chich-Jen , Pei Yu 
Published: January 2016

The enhancement of economic development and living standard in last years has the people stress more on recreational life that tourism becomes prevalent in Taiwan. County and city governments positively promote tourism and hold cultural festivals to enhance the boom of accommodation and catering industries and further fire national tourism market and catering industry.
Through online questionnaire survey, the customers of Wang Steak, TASTy, Tokiya, and ikki, which are the subsidiaries of Wowprime and burst out the oil scandal recently, are distributed 800 copies of questionnaires. Total 388 effective copies are retrieved with the effective rate 49%. The research results are concluded as follows. 1. Crisis Communication Strategies would affect Media Report. 2. Crisis Communication Strategies would influence Corporate Image. 3. Media Report has significantly positive effects on Managerial Capacity in Corporate Image. 4. Media Report presents remarkably positive effects on Corporate Reputation in Corporate Image. 5. Media Report shows notably positive effects on Communication News in Corporate Image. It is expected that catering businesses could enhance the countermeasures of Crisis Communication Strategies to cope with crises.
A Study Based on the Effect of Strategic Orientation on Management Innovation and Human Resource Management of a Business
Authors: Lei Ruan , Yan Zhang , Lei Peng 
Published: January 2016

Investigation on human resource role is progressing, and the influence of fits between human resources and business strategies have been confirmed in various studies. Such influence has also been proven as a good way to acquire organizational competitive advantages and achieve the optimal operating performance. Under such a context, a new variable, Management Innovation, is included in this study to observe the effects of such a practical and changeable variable on strategic orientation and human resource management role.
Top ten businesses in Fujian Province are selected for the questionnaire survey. Total 500 copies of questionnaire are distributed and 376 valid copies are retrieved, with the retrieval rate 75%. The research results show the positive effects of 1. strategic orientation on management innovation, 2. strategic orientation on human resource management role, and 3. management innovation on human resource management role. It expects to verify richer and multiple effects in this study for the reference of successive research and the practice.
Cultural Mapping and Urban Regeneration: Analyzing Emergent Narratives about Bilbao
Authors: Ortega Nuere Cristina , Bayón Fernando 
Published: January 2016

The role of culture in urban regeneration should be studied at different levels. Cultural mapping gives us a new understanding of the historical processes that have transformed public spaces in cities whose productive models and social relationships have undergone critical changes, affecting how they project their identity inside and outside their boundaries. Our research focuses on the case study of Bilbao (Basque Country, Spain). The first part of the analysis centres on a critical interpretation of the importance granted to cultural infrastructures in areas that were most intensely exposed to the changes which are known as the ‘Guggenheim effect’ on the international scene. This study especially examines the tension between today’s transformations and managing memories from the past. The second part analyses cultural mapping practices developed in emerging areas of the city such as the Zorrotzaurre peninsula, which is the new focus of the metropolitan development scheme. The proposals chosen for this study foster democratic responsibility in city management by using new technologies. They enable us take a closer look at some of the city’s most innovative collaborative cultural mapping practices, methodology and processes, as well as the theoretical frameworks that inspired them. Lastly, a proposal is put forth to implement participatory cultural mapping to identify the spillover effects of the cultural and creative industries located in renewed urban spaces.Keywords: cultural mapping, Bilbao, urban regeneration, social memory, creative citiesRésumé: Le rôle de la culture dans les stratégies de régénération urbaine devrait être étudié à plusieurs niveaux. La pratique de la cartographie culturelle révèle l’importance des processus historiques et des transformations identitaires à l’oeuvre dans les villes où les modèles productifs ont subi d’importantes mutations. Cet article met en évidence le cas de la ville de Bilbao dans le Pays basque espagnol. La première partie de cet article discute des incidences de « l’effet Guggenheim » sur l’ensemble des infrastructures culturelles de la ville. Cette partie met en relief la transformation et les enjeux mémoriels qui en découlent. La seconde partie de cet article discute de la cartographie culturelle de la péninsule de Zorrotzaurre, une partie de la vielle en pleine effervescence. Cet article adopte une attitude de responsabilisation démocratique dans son utilisation des nouvelles technologies pour la gestion municipale. Cet aspect est développé dans une réflexion sur l’usage des technologies, sur la participation publique l’impact des industries culturelles et creatives sur les éspaces urbaines rénouvelées.Mots clé: cartographie culturelle, Bilbao, régénération urbaine, mémoire sociale, villes créatives
Los cuentos del animal-novio: Los paradigmas de “Eros y Psique” y “La Bella y La Bestia”
Authors: Janer Maria de la Pau 
Published: January 2016

El artículo analiza la influencia de los cuentos populares en la historia de “Eros y Psique” contada por L. Apuleyo y profundiza en el estudio de este relato del siglo II d.C. al mismo tiempo que resalta los elementos que el autor extrae de las religiones egipcia y griega para, finalmente, establecer el modelo de amor que ha influido durante siglos en el imaginario de las sociedades occidentales. Analiza también el cuento de “La Bella y la Bestia” a partir de la versión de Madame Leprince de Beaumont. Indaga en la fascinación humana por el horror y se detiene en los posibles significados que pueden aplicarse al descubrimiento que, tras el rostro del monstruo, se esconde un ser humano que sufre las consecuencias de un sortilegio. Revisa los temas que tienen en común ambos relatos y señala sus diferencias, así como la diversidad de elementos mágicos que aparecen en ellos y que varían en las múltiples versiones recogidas de la tradición oral.