bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cost-efficiency of specialist inpatient rehabilitation for working-aged adults with complex neurological disabilities: a multicentre cohort analysis of a national clinical data set
Authors: Turner-Stokes Lynne , Williams Heather , Bill Alan , Bassett Paul , Sephton Keith 
Published: February 2016

ObjectivesTo evaluate functional outcomes, care needs and cost-efficiency of specialist rehabilitation for a multicentre cohort of inpatients with complex neurological disability, comparing different diagnostic groups across 3 levels of dependency.DesignA multicentre cohort analysis of prospectively collected clinical data from the UK Rehabilitation Outcomes Collaborative (UKROC) national clinical database, 2010–2015.SettingAll 62 specialist (levels 1 and 2) rehabilitation services in England.ParticipantsWorking-aged adults (16–65 years) with complex neurological disability. Inclusion criteria: all episodes with length of stay (LOS) 8–400 days and complete outcome measures recorded on admission and discharge. Total N=5739: acquired brain injury n=4182 (73%); spinal cord injury n=506 (9%); peripheral neurological conditions n=282 (5%); progressive conditions n=769 (13%).InterventionSpecialist inpatient multidisciplinary rehabilitation.Outcome measuresDependency and care costs: Northwick Park Dependency Scale/Care Needs Assessment (NPDS/NPCNA). Functional independence: UK Functional Assessment Measure (UK Functional Independence Measure (FIM)+FAM). Cost-efficiency: (1) time taken to offset rehabilitation costs by savings in NPCNA-estimated costs of ongoing care, (2) FIM efficiency (FIM gain/LOS days), (3) FIM+FAM efficiency (FIM+FAM gain/LOS days). Patients were analysed in 3 groups of dependency.ResultsMean LOS 90.1 (SD 66) days. All groups showed significant reduction in dependency between admission and discharge on all measures (paired t tests: p<0.001). Mean reduction in ‘weekly care costs’ was greatest in the high-dependency group at £760/week (95% CI 726 to 794)), compared with the medium-dependency (£408/week (95% CI 370 to 445)), and low-dependency (£130/week (95% CI 82 to 178)), groups. Despite longer LOS, time taken to offset the cost of rehabilitation was 14.2 (95% CI 9.9 to 18.8) months in the high-dependency group, compared with 22.3 (95% CI 16.9 to 29.2) months (medium dependency), and 27.7 (95% CI 15.9 to 39.7) months (low dependency). FIM efficiency appeared greatest in medium-dependency patients (0.54), compared with the low-dependency (0.37) and high-dependency (0.38) groups. Broadly similar patterns were seen across all 4 diagnostic groups.ConclusionsSpecialist rehabilitation can be highly cost-efficient for all neurological conditions, producing substantial savings in ongoing care costs, especially in high-dependency patients.
Development of the Chinese version of the Hospital Autonomy Questionnaire: a cross-sectional study in Guangdong Province
Authors: Liu Zifeng , Yuan Lianxiong , Huang Yixiang , Zhang Lingling , Luo Futian 
Published: February 2016

ObjectiveWe aimed to develop a questionnaire for quantitative evaluation of the autonomy of public hospitals in China.MethodAn extensive literature review was conducted to select possible items for inclusion in the questionnaire, which was then reviewed by 5 experts. After a two-round Delphi method, we distributed the questionnaire to 404 secondary and tertiary hospitals in Guangdong Province, China, and 379 completed questionnaires were collected. The final questionnaire was then developed on the basis of the results of exploratory and confirmatory factor analysis.ResultsAnalysis suggested that all internal consistency reliabilities exceeded the minimum reliability standard of 0.70 for the α coefficient. The overall scale coefficient was 0.87, and 6 subscale coefficients were 0.92 (strategic management), 0.81 (budget and expenditure), 0.85 (financing), 0.75 (financing, medical management), 0.86 (human resources) and 0.86 (accountability). Correlation coefficients between and among items and their hypothesised subscales were higher than those with other subscales. The value of average variance extracted (AVE) was higher than 0.5, the value of construct reliability (CR) was higher than 0.7, and the square roots of the AVE of each subscale were larger than the correlation of the specific subscale with the other subscales, supporting the convergent and discriminant validity of the Chinese version of the Hospital Autonomy Questionnaire (CVHAQ). The model fit indices were all acceptable: χ2/df=1.73, Goodness of Fit Index (GFI) = 0.93, Adjusted Goodness of Fit Index (AGFI) = 0.91, Non-Normed Fit Index (NNFI) = 0.96, Comparative Fit Index (CFI) = 0.97, Root Mean Square Error of Approximation (RMSEA) = 0.04, Standardised Root Mean Square Residual (SRMR) = 0.07.ConclusionsThis study demonstrated the reliability and validity of a CVHAQ and provides a quantitative method for the assessment of hospital autonomy.
Prehospital and in-hospital use of healthcare resources in patients surviving acute coronary syndromes: an analysis of the EPICOR registry
Authors: Annemans Lieven , Danchin Nicolas , Van de Werf Frans , Pocock Stuart , Licour Muriel , Medina Jesús , Bueno Héctor 
Published: February 2016

ObjectiveThe aim of this report is to provide insight into real-world healthcare resource use (HCRU) during the critical management of patients surviving acute coronary syndromes (ACS), using data from EPICOR (long-tErm follow-up of antithrombotic management Patterns In acute CORonary syndrome patients) (NCT01171404).MethodsEPICOR was a prospective, multinational, observational study that enrolled 10 568 ACS survivors from 555 hospitals in 20 countries in Europe and Latin America, between September 2010 and March 2011. HCRU was evaluated in patients with ST-segment elevation myocardial infarction (STEMI) or non-ST-segment elevation ACS (NSTE-ACS), with or without a history of cardiovascular disease (CVD). Multivariable analysis was performed to determine factors that affected resource use.ResultsBefore hospitalisation, more patients with STEMI than with NSTE-ACS had their first ECG (44.1% vs 36.4%, p<0.0001) and received antithrombotic medication (26.6% vs 15.2%, p<0.0001). Patients with NSTE-ACS with prior CVD were less likely than those without to be catheterised (73.1% vs 82.8%, p<0.0001). More patients with STEMI than with NSTE-ACS had percutaneous coronary intervention (77.1% vs 54.9%, p<0.0001), but fewer underwent coronary artery bypass grafting (1.2% vs 3.7%, p<0.0001). Multivariable analysis showed that resource use, including length of hospital stay and coronary revascularisation, was significantly influenced by multiple factors, including ACS type, site characteristics and region (all p≤0.05).ConclusionsIn this large-scale, real-life study, findings were generally in line with clinical logic, although site characteristics and region still significantly affected resource use. Moreover, and unexpectedly, resource use tended to be slightly higher in patients without a history of CVD.Trial registration numberNCT01171404 (ClinicalTrials.gov).
The Double Peak in Upwelling and Heating in the Tropical Lower Stratosphere
Authors: Ming Alison , Hitchcock Peter , Haynes Peter 
Published: February 2016

Abstract
The processes responsible for double-peak latitudinal structures in the time-averaged tropical lower-stratospheric upwelling, centered near 70 hPa and 20°N/S, previously noted in ERA-Interim and other reanalysis and model datasets, are considered. It is demonstrated that the structure of the wave force resolved by ERA-Interim consistently balances the angular momentum transport associated with the double peak. Analysis of the corresponding structures in diabatic heating rates from ERA-Interim indicates that the peaks arise predominantly from the meridional structure in ozone concentrations and the associated absorption of both shortwave and longwave radiation. Additional smaller contributions arise from local absorption of longwave radiation emitted from the relatively warm layers above and below, as well as from cloud-related radiative effects and nonradiative diabatic heating. The temperature at 70 hPa is slightly higher near 20°N/S than at the equator, opposite of what would be expected if the latitudinal structure in radiative heating were associated with local relaxation. It is proposed on the basis of this analysis that the primary cause of the peaks in upwelling is the externally imposed (i.e., nonrelaxational) part of the radiative heating field. The dynamical plausibility of this hypothesis is investigated in a companion paper.
Highlights from the 11th ISCB Student Council Symposium 2015
Authors: Wilkins Katie , Hassan Mehedi , Francescatto Margherita , Jespersen Jakob , Parra R. Gonzalo , Cuypers Bart , DeBlasio Dan , Junge Alexander , Jigisha Anupama , Rahman Farzana , Laenen Griet , Willems Sander , Thorrez Lieven , Moreau Yves , Raju Nagarajan , Chothani Sonia Pankaj , Ramakrishnan C. , Sekijima Masakazu , Gromiha M. Michael , Slator Paddy J , Burroughs Nigel J , Szałaj Przemysław , Tang Zhonghui , Michalski Paul , Luo Oskar , Li Xingwang , Ruan Yijun , Plewczynski Dariusz , Fiscon Giulia , Weitschek Emanuel , Ciccozzi Massimo , Bertolazzi Paola , Felici Giovanni , Cuypers Bart , Meysman Pieter , Vanaerschot Manu , Berg Maya , Imamura Hideo , Dujardin Jean-Claude , Laukens Kris , Domanova Westa , Krycer James R. , Chaudhuri Rima , Yang Pengyi , Vafaee Fatemeh , Fazakerley Daniel J. , Humphrey Sean J. , James David E. , Kuncic Zdenka 
Published: February 2016

Table of contentsA1 Highlights from the eleventh ISCB Student Council Symposium 2015Katie Wilkins, Mehedi Hassan, Margherita Francescatto, Jakob Jespersen, R. Gonzalo Parra, Bart Cuypers, Dan DeBlasio, Alexander Junge, Anupama Jigisha, Farzana RahmanO1 Prioritizing a drug’s targets using both gene expression and structural similarityGriet Laenen, Sander Willems, Lieven Thorrez, Yves MoreauO2 Organism specific protein-RNA recognition: A computational analysis of protein-RNA complex structures from different organismsNagarajan Raju, Sonia Pankaj Chothani, C. Ramakrishnan, Masakazu Sekijima; M. Michael GromihaO3 Detection of Heterogeneity in Single Particle Tracking TrajectoriesPaddy J Slator, Nigel J BurroughsO4 3D-NOME: 3D NucleOme Multiscale Engine for data-driven modeling of three-dimensional genome architecturePrzemysław Szałaj, Zhonghui Tang, Paul Michalski, Oskar Luo, Xingwang Li, Yijun Ruan, Dariusz PlewczynskiO5 A novel feature selection method to extract multiple adjacent solutions for viral genomic sequences classificationGiulia Fiscon, Emanuel Weitschek, Massimo Ciccozzi, Paola Bertolazzi, Giovanni FeliciO6 A Systems Biology Compendium for Leishmania donovaniBart Cuypers, Pieter Meysman, Manu Vanaerschot, Maya Berg, Hideo Imamura, Jean-Claude Dujardin, Kris LaukensO7 Unravelling signal coordination from large scale phosphorylation kinetic dataWesta Domanova, James R. Krycer, Rima Chaudhuri, Pengyi Yang, Fatemeh Vafaee, Daniel J. Fazakerley, Sean J. Humphrey, David E. James, Zdenka Kuncic
A multiple testing procedure for multi-dimensional pairwise comparisons with application to gene expression studies
Authors: Grandhi Anjana , Guo Wenge , Peddada Shyamal D. 
Published: February 2016

AbstractBackgroundOften researchers are interested in comparing multiple experimental groups (e.g. tumor size) with a reference group (e.g. normal tissue) on the basis of thousands of features (e.g. genes) and determine if a differentially expressed feature is up or down regulated in a pairwise comparison. There are two sources of false discoveries, one due to multiple testing involving several pairwise comparisons and the second due to falsely declaring a feature to be up (or down) regulated when it is not (known as directional error). Together, the total error rate is called the mixed directional false discovery rate (mdFDR).ResultsWe develop a general powerful mdFDR controlling testing procedure and illustrate the methodology by analyzing uterine fibroid gene expression data (PLoS ONE 8:63909, 2013). We identify several differentially expressed genes (DEGs) and pathways that are specifically enriched according to the size of a uterine fibroid.ConclusionsThe proposed general procedure strongly controls mdFDR. Several specific methodologies can be derived from this general methodology by using appropriate testing procedures at different steps of the general procedure. Thus we are providing a general framework for making multiple pairwise comparisons. Our analysis of the uterine fibroid growth gene expression data suggests that molecular characteristics of a fibroid changes with size. Our powerful methodology allowed us to draw several interesting conclusions regarding the molecular characteristics of uterine fibroids. For example, IL-1 signaling pathway (Sci STKE 2003:3, 2003), associated with inflammation and known to activate prostaglandins that are implicated in the progression of fibroids, is significantly enriched only in small tumors (volume < 5.7cm3). It appears that the molecular apparatus necessary for fibroid growth and development is established during tumor development. A complete list of all DEGs and the corresponding enriched pathways according to tumor size is provided for researchers to mine these data. Identification of these DEGs and the pathways may potentially have clinical implications.
First-In-Human safety and long-term exposure data for AAB-003 (PF-05236812) and biomarkers after intravenous infusions of escalating doses in patients with mild to moderate Alzheimer’s disease
Authors: Delnomdedieu Marielle , Duvvuri Sridhar , Li David Jianjun , Atassi Nazem , Lu Ming , Brashear H. Robert , Liu Enchi , Ness Seth , Kupiec James W. 
Published: February 2016

Abstract
Background
In the First-In-Human (FIH), 39-week, randomized, adaptive design study, safety, tolerability, pharmacokinetics and biomarkers were measured in patients with mild-to-moderate Alzheimer’s disease (AD) after infusion of a humanized monoclonal antibody to amyloid β, AAB-003 (NCT01193608; registered 19 August 2010). AAB-003 was developed by modifying bapineuzumab to reduce Fc-receptor-mediated effector function as a strategy to reduce the removal of amyloid from vessel walls associated with amyloid-related imaging abnormalities with edema/effusions (ARIA-E) without diminishing overall amyloid clearance.

Methods
Eighty-eight patients with AD received up to three infusions of AAB-003 (or placebo) 13 weeks apart at doses of 0.5, 1, 2, 4 or 8 mg/kg in the FIH trial. Dose escalation was based on safety data reviews using a Bayesian escalation algorithm. Subjects who completed the FIH study were permitted to enter a 1-year open-label extension trial with four additional intravenous infusions of AAB-003 (NCT01369225; registered 10 May 2011).

Results
Dose-dependent increases in plasma amyloid β and AAB-003 were observed. No significant changes in cerebral spinal fluid biomarkers were observed. Pharmacokinetics elimination half-life (21–28 days) clearance and volume of distribution values were consistent across dose groups indicating linearity. ARIA-E was the most notable safety finding detected by magnetic resonance imaging (MRI) at 8 mg/kg in two patients. Three cases of microhemorrhage were observed. No new safety findings or MRI abnormalities were observed for the 52 subjects who received AAB-003 in the extension trial.

Conclusion
Based on integrated review of laboratory, electrocardiogram, adverse events, and MRI, AAB-003 was safe and well tolerated up to 8 mg/kg for up to 91 weeks (FIH and extension trials) in patients with mild to moderate AD. Asymptomatic and resolvable ARIA-E was observed after the first or second infusion of AAB-003, similar to bapineuzumab. The AAB-003 dose at which ARIA-E was observed was higher compared to bapineuzumab, supporting the hypothesis that reducing Fc-receptor effector function may reduce the ARIA associated with monoclonal antibodies targeting cerebral amyloid.
Migration patterns of San Francisco Bay Area Hermit Thrushes differ across a fine spatial scale
Authors: Nelson Allison R. , Cormier Renée L. , Humple Diana L. , Scullen Josh C. , Sehgal Ravinder , Seavy Nathaniel E. 
Published: February 2016

AbstractEffective conservation of short-distance migrants requires an understanding of intraspecific variation in migratory patterns across small spatial scales. Until the advent of ultra-light geolocation devices, our knowledge of the migratory connectivity of songbirds was limited. For the Hermit Thrush (Catharus guttatus), subspecies delineations and connectivity patterns have been unclear in the portion of their breeding range in western North America from southeastern Alaska to northwestern Washington, where individuals wintering in the San Francisco Bay Area of California purportedly breed. To determine breeding locations and migratory timing of the Bay Area’s wintering Hermit Thrushes, we deployed geolocators at sites to the north and south of the San Francisco Bay. We compared results from these two regions to one another and to connectivity patterns suggested by subspecies definitions. We collected morphometrics to identify regional differences. Hermit Thrushes that wintered in the North Bay had a wider and more southerly breeding distribution from the British Columbia coast to northwestern Washington, whereas South Bay thrushes migrated to southeastern Alaska and the British Columbia coast. In general, North Bay thrushes departed wintering grounds and arrived on breeding grounds earlier than South Bay thrushes, but we cannot eliminate sex as a factor in these differences. Regional morphology differed only in bill length. Intraspecific isolation in glacial refugia during the Late Pleistocene may explain these fine-scale geographic variations in migration patterns and morphology.
Magnetic resonance brain classification by a novel binary particle swarm optimization with mutation and time-varying acceleration coefficients
Authors: Wang Shuihua , Phillips Preetha , Yang Jianfei , Sun Ping , Zhang Yudong 
Published: February 2016

AbstractAim:To develop an automatic magnetic resonance (MR) brain classification that can assist physicians to make a diagnosis and reduce wrong decisions.Method:This article investigated the binary particle swarm optimization (BPSO) approach and proposed its three new variants: BPSO with mutation and time-varying acceleration coefficients (BPSO-MT), BPSO with mutation (BPSO-M), and BPSO with time-varying acceleration coefficients (BPSO-T). We first extracted wavelet entropy (WE) features from both approximation and detail sub-bands of eight-level decomposition. Afterwards, we used the proposed BPSO-M, BPSO-T, and BPSO-MT to select features. Finally, the selected features were fed into a probabilistic neural network (PNN).Results:The proposed BPSO-MT performed better than BPSO-T and BPSO-M. It finally selected two features of entropies of the following two sub-bands (V1, D1). The proposed system “WE + BPSO-MT + PNN” yielded perfect classification on Data160 and Data66. In addition, it yielded 99.53% average accuracy for the Data255, over 10 repetitions of k-fold stratified cross validation (SCV), higher than state-of-the-art approaches.Conclusions:The proposed method is effective for MR brain classification.
Kalbančios sienos Wolfgango Hilbigo romane Laikinumas ir Sigito Parulskio romane Murmanti siena
Authors: Katinienė Violeta 
Published: February 2016

Seit der Wende 1989 wird das Problem der Grenze in der neuesten deutschen Literatur viel diskutiert. Die­ses allgemeinmenschliche Thema ist auch in Litau­en, als einem postsowjetischen Staat, aktuell. Nach dem Zerfall der äußeren Grenzen sind jedoch im Bewusstsein der Menschen die innerlichen Grenzen geblieben. In diesem Artikel wird anhand von zwei Romanen (Murmanti siena/Die murmelnde Mauer,2008 von Sigitas Parulskis und Das Provisorium/Laikinumas, 2000 von Wolfgang Hilbig) das Phäno­men der Existenz an der Grenze näher betrachtet. In beiden Romanen erscheint die Grenze als real exi­stierend und als innerlicher Zustand. In der Metapher der Grenze sind Überschreitung, Überwindung, das Treffen mit dem Anderen, ein Schwellenzustand ver­borgen. Die Protagonisten beider Romane befinden sich an der Schwelle, in der Grenzzone, die sie be­ängstigt, aber auch die Schwelle (oder sich selbst) zu überwinden – die Grenze zu überschreiten – zwingt. Das Ziel dieser Arbeit ist es Fragen aufzuwerfen, die in Verbindung mit dem Phänomen der Grenze, den Versuchen sie zu überwinden in Verbindung stehen. Die Erfahrungen, die sich in den Texten offenbaren, werden anhand phänomenologischer Begriffe unter­sucht. Die aufgeworfenen Fragen könnten später zu tieferen Erkenntnissen führen.
Body composition and maximal oxygen consumption in adult soccer players in the Republic of Macedonia
Authors: Pluncevikj Gligoroska Jasmina , Manchevska Sanja , Efremova Ljudmila , Todorovska Lidija , Nikolic Slobodan 
Published: February 2016

Introduction: The purpose of this study was to investigate the relationship between active and passive body mass components and maximal aerobic consumption (VO2max) in adult male soccer players.Methods: The study involved seven hundred (700) male soccer players, mean age 25.06 ± 4.41 years (range 18 to 35), divided in six age groups. Body composition was assessed according the anthropometric protocol by Matiegka, and relative muscle mass (MM%), bone (BM%) and fat (BF%) and absolute muscle mass (MMkg), bone (BMkg) and fat (BFkg) components were calculated. The Bruce protocol (incremental multistage treadmill test) was used for the estimation of maximal oxygen consumption.Results: Mean values of body mass components for total sample were as follows: muscle mass (MM%)= 52.75 ± 2.63%, bone mass (BM%)=16.63 ± 1.29% and body fat (BF%)=14.12 ± 1.54%. Mean VO2max was 48.89±5.17 ml/kg/minute. Relative muscle mass (MM%) showed similar values across age different groups (ANOVA: F=2.174; p=0.06) while absolute muscle mass (MMkg) showed tendency of increment with age (ANOVA: F=2.136; p=0.01). Body fat (BFkg and BF%) was statistically higher in the older groups (ANOVA F=3.737; p<0.01; ANOVA F=4.117; p<0.01). Weak positive correlation between VO2 max and muscle component (r=0.243; p<0.001) and a weak negative correlation between VO2max and body fat (r=-0.08;p<0.05) were found.Conclusions: Our results confirm the assumption that subjects with larger muscle mass have greater endurance and higher maximal oxygen consumption compared to subjects with larger body fat component.
Study Fails to Link ILL Usage Patterns to Liaison Activities
Authors: Marsalis Scott 
Published: February 2016

A Review of:
Leykam, Andrew. “Exploring Interlibrary Loan Usage Patterns and Liaison Activities: The Experience at a U.S. University.” Interlending & Document Supply 36.4 (2008): 218-24.

Objective - To investigate Interlibrary Loan (ILL) usage patterns, and connect them to liaison activities beyond collection development.

Design – Pattern analysis of ILL requests.

Setting – Library of The College of Staten Island, a mid-size, public university with predominantly undergraduate enrolment.

Subjects – 4,875 identifiable requests over a three-year period.

Methods – A data set of requests for ILLs of monographs over a period of three years was acquired from OCLC resource sharing statistics. This data was manually reviewed to remove duplicate records of the same request, but not multiple requests for the same item. The data included requestor status, department, publication date and subject classification of requested items.

Main Results – Differences in use across user statuses and departments were identified.

Conclusion – Usage Patterns can accurately illustrate trends in the borrowing behaviour of patrons, and be used to inform liaison librarians about user needs.