bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activating the regenerative potential of Müller glia cells in a regeneration-deficient retina
Authors: Lust Katharina , Wittbrodt Joachim 
Published: August 2017

SummaryRegeneration responses in animals are widespread across phyla. To identify molecular players that confer regenerative capacities to non-regenerative species is of key relevance for basic research and translational approaches. Here we report a differential response in retinal regeneration between medaka (Oryzias latipes) and zebrafish (Danio rerio). In contrast to zebrafish, medaka Müller glia (olMG) cells behave like progenitors and exhibit a restricted capacity to regenerate the retina. After injury, olMG cells proliferate but fail to self-renew and ultimately only restore photoreceptors.In our injury paradigm, we observed that in contrast to zebrafish, proliferating olMG cells do not maintainsox2expression. Sustainedsox2expression in olMG cells confers regenerative responses similar to those of zebrafish MG (drMG) cells. We show that a single, cell-autonomous factor reprograms olMG cells and establishes a regeneration-like mode. Our results position medaka as an attractive model to delineate key regeneration factors with translational potential.
Metabolic Model-Based Analysis of the Emergence of Bacterial Cross-Feeding through Extensive Gene Loss
Authors: McNally Colin P , Borenstein Elhanan 
Published: August 2017

AbstractMetabolic dependencies between microbial species are common and have a significant impact on the assembly and resilience of microbial communities. However, the origins of such metabolic dependencies, the evolutionary forces that drive metabolic cross-feeding, and the impact of metabolic and genomic architecture on their emergence are not clear. To address these questions, we developed a novel simulation-based framework coupling a model of reductive evolution with a multi-species genome-scale model of microbial metabolism. We used this framework to model the evolution of a two-species microbial community, simulating thousands of independent evolutionary trajectories and investigating the link between genome reductive evolution and the emergence of metabolic interactions. Surprisingly, even though our model does not impose explicit selection for cooperation, metabolic dependencies emerged in nearly half of all evolutionary runs. Evolved dependencies involved cross-feeding of a diverse set of metabolites at varying frequencies, reflecting various constraints imposed by the metabolic network architecture. We additionally found metabolic ‘missed opportunities’, wherein species failed to capitalize on metabolites made available by their partners. When cross-feeding did evolve, it generally emerged immediately after a metabolite became available, but a complete dependence on such cross-fed metabolites often evolved relatively slowly. Examining the genes deleted and retained in each evolutionary trajectory and the timing of gene deletion events along these trajectories, we were further able to identify both genome-wide properties and specific gene retentions that were associated with metabolic phenotypes. Our findings provide insight into the evolution of cooperative metabolic interaction among microbial species, offering a unique view into the way such relationships could emerge in natural settings.
Schooling health: the critical contribution of curriculum in the 1980s
Authors: Leahy Deana , Penney Dawn , Welch Rosie 
Published: August 2017

Purpose
Public health authorities have long regarded schools as important sites for improving children and young people’s health. In Australia, and elsewhere, lessons on health have been an integral component of public health’s strategy mix. Historical accounts of schools’ involvement in public health lack discussion of the role of health education curriculum. The purpose of this paper is to redress this silence and illustrate the ways health education functioned as a key governmental apparatus in Victoria in the 1980s.

Design/methodology/approach
The paper draws on governmentality studies to consider the explicit governmental role of official health education curriculum in the 1980s in Victoria, Australia. The authors conduct a discourse analysis of the three official curriculum texts that were released during this period to consider the main governmental rationalities and techniques that were assembled together by curriculum writers.

Findings
School health education functions as a key governmental apparatus of governmentality. One of its major functions is to provide opportunities to responsibilise young people with an aim to ensure that that they can perform their duty to be well. The authors demonstrate the central role of policy events in the 1970s and how they contributed to conditions of possibility that shaped versions of health education throughout the 1980s and beyond. Despite challenges posed by the critical turn in health education in the late 1980s, the governmental forces that shape health education are strong and have remained difficult to displace.

Originality/value
Many public health and schooling histories fail to take into account insights from the history of education and curriculum studies. The authors argue that in order to grasp the complexities of school health education, we need to consider insights afforded by curriculum histories. Historical insights can provide us with an understanding of the changing approaches to governing health in schools.
School medical inspection and the “healthy” child in the Netherlands, 1904-1970
Authors: Bakker Nelleke 
Published: August 2017

Purpose
The purpose of this paper is to explore the meaning of child health as applied by school doctors in the Netherlands and the way it was adapted to the rapidly improving standard of living and the increasing importance of mental health after the Second World War. The extension of the concept beyond physical health into emotional and social well-being is particularly interesting as the school medical inspection was the only public child-hygienic service in a country where religious groups opposed the extension of public hygienic care into parenting and the family.

Design/methodology/approach
On the basis of secondary literature, the paper discusses the early development of Dutch school medical inspection from a comparative perspective. Changes in the national authority’s and the school doctors’ concepts of what a “healthy” child was between the 1930s and 1970 are examined using a variety of primary sources. These concern both the national discourse and sources that shed light on the daily practice of school medical inspection from the single province for which these are available.

Findings
Although they adopted a new and more inclusive concept of health in theory, school doctors in the Netherlands were reluctant to actually take up issues of mental health in their daily practice. This reluctance was inspired by the fear of losing their pivotal role in child hygiene and their status as public servants.

Originality/value
Studies in the history of school medical services have focussed mainly on their establishment and development as an institution. They seldom extend into the post-war era and do not discuss the extension of the inspection into mental health.
Competitive advantage through Six Sigma at plastic injection molded parts manufacturing unit
Authors: Desai Darshak , Prajapati Bhavikkumar Nileshbhai 
Published: August 2017

Purpose
The purpose of this paper is to illustrate the successful application of Six Sigma at a small and medium scale plastic parts manufacturing unit. Overall operational excellence is one of the foundations of global competiveness. Indian industries are also keeping up with achieving and maintaining operational excellence through different improvement tools and methodologies. Plastic parts manufacturing industries in India are also on the move to increase their overall quality, productivity and profitability. However, it appears from the available literature that application of Six Sigma, one of the most effective breakthrough improvement strategies having direct impact on bottom line of the organization, is not being explored to its full potential, especially at plastic parts manufacturing industries in India. This study was thus undertaken at plastic products manufacturing plant to introduce Six Sigma to them by applying the same to their chronic problems and drawing improvements in quality, productivity and profitability.

Design/methodology/approach
This paper illustrates the real-life case study of improving quality and productivity of injection molding process by phase wiz application of define, measure, analyze, improve and control, the process improvement methodology of Six Sigma.

Findings
The critical defects, such as short molding, contamination, injection point and flash are reduced from the process leading to annual savings of INR 10.80 lacs. This is a considerable amount for a small concern in question.

Research limitations/implications
Because this was the pilot project and the firm was of small and medium size, data collection was the major issue, which consequently took considerable time and efforts at define and measure phases. Injection molding is a very salient process for plastic products manufacturing. Almost one-third of plastic products are made by this process. Thus, improving quality of products made out of injection molding process is of paramount importance. The paper is an attempt to exhibit how a small-scale plastic injection molded parts manufacturing unit can put fruitful efforts to achieve competitive advantage through Six Sigma.

Originality/value
From the review of literature, it appears that application of Six Sigma among plastic parts manufacturing units, especially small and medium, is very rare, not in India but across the globe. This case study has opened up the direction to small- and medium-scale plastic parts manufacturing units to implement Six Sigma and to move a step forward toward achieving competitive advantage.
Lean thinking: planning and implementation in the public sector
Authors: de Almeida Juliana Pascualote Lemos , Galina Simone Vasconcelos Ribeiro , Grande Marcia Mazzeo , Brum Daiane Gressler 
Published: August 2017

Purpose
The purpose of this paper is to analyse how Lean office planning and implementation take place in a Brazilian regulatory agency and to investigate the adjustments needed for its implementation.

Design/methodology/approach
A longitudinal case study was conducted. Interview was the main source of evidence. Between September and October 2012, data about the planning phase were collected; between April and May 2015, Lean office implementation was investigated. Altogether, five employees of the agency were interviewed.

Findings
The agency assumed its mission as value for the user, establishing control process, evaluating and improving processes to achieve perfection and recognising its weakness in a continuous improvement culture. Planning and implementation of Lean office in the regulatory agency followed the main recommendations in the literature. However, adjustments were necessary in accordance with the particularities of the public institution.

Research limitations/implications
Owing to the nature of this study, no generalisation was possible. Moreover, interviews with managers were about both Lean planning, which has taken place in the past, and Lean implementing, which is still running; thus, some information may be abstruse.

Practical implications
It was possible to list the main adjustments needed for planning and implementing the Lean office in the public agency and some are applicable for other public administration bodies.

Originality/value
Lean office studies are mainly related to private organizations, but this paper demonstrates that their fundamentals are preserved in public service, and thus it proved that Lean thinking may be applied to the public administration. It also raised a series of questions for future studies.
Investing in work: exclusionary inclusion in Austria, Belgium and Norway
Authors: Gubrium Erika K. , Leibetseder Bettina , Dierckx Danielle , Raeymaeckers Peter 
Published: August 2017

PurposeThe purpose of this paper is to compare the impact of two social investment strategies (labour activation and governance coordination) targeted to social assistance clients within three different welfare-system coordination cases, with focus on social and economic inclusion.Design/methodology/approachThe authors focus on the impact of reform at micro (individually experienced impact), meso (impact across settings) and macro (socio-structural impact) levels.FindingsWhile social investment reform has given some clients new opportunities, in no study case were clients fully able to use the incentive-driven strategies. Reforms have led to a “Matthew effect”: the better resourced reap the largest benefit from new services on offer while the less resourced have their marginal socioeconomic position reinforced. Clients may internalise their relative activation success. Intimate connections between macro- and micro-impacts may have heightened the sense of social and economic exclusion, stigma and shame experienced by those who are most vulnerable.Social implicationsSocial investment reform (labour activation) may not be a model that reduces social and economic exclusion and it may, instead, reify socioeconomic marginalisation, enhancing sense of stigma and shame and reducing self-efficacy.Originality/valueScholars have assessed social investment according to its economic performance, but there has been a lack of research considering impact of reform on socioeconomic inclusion.
Making sense of contemporary disasters: a liquid development perspective
Authors: Perkiss Stephanie , Handley Karen 
Published: August 2017

Purpose
The purpose of this paper is to explore economic conditions of contemporary society to provide insight into the ways in which the consequences of disaster, including environmental migration, are accentuated.

Design/methodology/approach
This research draws on Zygmunt Bauman’s theory of liquid modernity and notions of development to analyse disaster. From the analysis, a new concept, liquid development, is proposed and critiqued as a contributing factor leading to severe contemporary disaster.

Findings
Liquid development provides a new way of making sense of the conditions and consequences of economic growth and a business as usual attitude. It further provides a framework to explore the potential disaster of environmental migration in the Pacific Islands arising from liquid development driven climate change-induced sea level rise.

Research limitations/implications
Analysing these conditions provides greater understanding of the resulting impact of disaster, creating awareness and informing the need for accountability and social policy. This study aims to contribute to further practical and research enquiry that will challenge liquid developers to reconsider their impact and to accept responsibility for vulnerable members of society as part of their business as usual structure.

Originality/value
This paper adds to Bauman’s understanding of the consequences of globalisation through the construct of liquid development. It also continues his debate by giving awareness to the global issue of environmental migration.
Female knowledge workers and the illusion of working-time autonomy
Authors: Tammelin Mia , Koivunen Tuija , Saari Tiina 
Published: August 2017

PurposeThe purpose of this paper is to ask: what are the temporal realities of female knowledge workers? It especially focusses on women’s possibilities of using working-time autonomy, and the work and non-work practices that shape their possibility to use work-hour autonomy. In knowledge work, working-time autonomy is usually high, but exercising autonomy is not always possible. The study was carried out in Finland, where full-time work is common also among women, even if they have small children.Design/methodology/approachThe data include 19 semi-structured interviews of women who have knowledge-intensive work. The method of analysis is problem-driven content analysis.FindingsFemale knowledge workers intertwine several temporal realities. The utilisation of working-time autonomy is restricted by unpredictability, continuous interruptions, hurriedness and ineffective work practices. The temporal realities of family life, such as taking children to the daycare or school, other everyday routines and a spouse’s working-time autonomy have an effect on women’s possibilities to use working-time autonomy. The line between work and non-work blurs.Originality/valueThis study sheds light on working-time autonomy among female knowledge workers. It adds an understanding to the temporal realities of work and outside work that influence the use of work-hour autonomy. This information is needed to understand time demands arising from work, which play a role in work-family research in particular.
Changing concerns of beginning Dutch university teachers
Authors: van den Bos Paul 
Published: August 2017

Purpose
The purpose of this paper is to address the concerns of beginning university teachers about learning to teach in the context of an induction programme.

Design/methodology/approach
The author asked 162 beginning teachers at Dutch universities of applied sciences to express their concerns about teaching. Of those, the author first asked 44 teachers to write down their concerns freely. These open statements were categorised and translated to a 20-item questionnaire, which was completed by the remaining 118 teachers before and after the induction programme.

Findings
Statistical analysis identified three main concerns: activating students, being an effective teacher in general, and being sufficiently facilitated and supported in the teaching context. While concerns about activating students and being an effective teacher were reduced after the programme, concerns about the supportiveness of the teaching context remained unchanged.

Research limitations/implications
The study was conducted in the context of a specific induction programme with a specific pedagogical design; thus, generalisation of the results should be done carefully. Additionally, while the instrument that was developed in this study must be improved, this study indicates a relevant problem: the results of induction programmes might be less sustainable without a proper supportive organisational context.

Originality/value
The study adds insight into the concerns of beginning university teachers and highlights some consequences at the organisational level.
Doctoral student support programs in diverse national contexts
Authors: Caliskan Omer , Holley Karri 
Published: August 2017

Purpose
The growing demand for doctoral education and the role of the doctoral degree to advance nations socially, economically, and culturally forces countries and individual institutions to respond to concerns stemming from the doctoral process. Numerous initiatives to support doctoral students have been adopted with varying features across countries. The purpose of this paper is to examine doctoral student support programs in two countries: the USA and Turkey. These countries offer higher education systems at different stages of maturity and stability.

Design/methodology/approach
The data for this study came from a comparative case study analysis of doctoral student experiences in support programs at two research universities, one in the USA and one in Turkey. Ten American doctoral students and eight Turkish doctoral students were interviewed, for a total of 18 interviews. The study utilized the conceptual framework specified by the PhD Completion Project initiated by the US Council of Graduate Schools.

Findings
The two national systems featured in this study are at different points of their development. These developmental starting points influence the rationale and construction of a student support program, particularly one focused on advanced degrees, research activity, and knowledge production. The Turkish higher education system faces the challenge of building its infrastructure to be responsive to national needs in future decades, including producing qualified faculty as teachers and researchers. The American model of doctoral student support concentrates on increasing diversity within the academy. By focusing on first-generation students, students of color, and women in STEM disciplines, efforts are directed toward not just improving the quantity of graduates, but also the diversity of those graduates.

Originality/value
While doctoral student support programs are increasingly common in multiple national contexts, analyses of these programs are rare, and comparative analyses even more so. The emergence of new academic disciplines, the trend toward interdisciplinary research, and the prevalence of neo-liberal policies has made the doctoral experience increasingly complex. The data presented here reveal that while doctoral education is influenced by country-specific contexts, doctoral students from multiple countries share many of the same experiences.
Social skills as a moderator between R&D personnel’s knowledge sharing and job performance
Authors: Yun Yang-Joong , Lee Kyoung-Joo 
Published: August 2017

PurposeResearch and development (R&D) personnel are an organization’s ultimate source of creative knowledge. Thus, their job performance ensures an organization’s innovative capability. Focusing on the process nature of creativity and innovation in organizations, the purpose of this paper is to analyze the influence of R&D personnel’s active knowledge sharing on their job performance and highlight the significance of social skills by examining their moderation effect.Design/methodology/approachThis study conducted a survey of 252 R&D personnel in 60 R&D organizations in large South Korean firms. Data reliability and validity were confirmed, and regression analysis was performed to test the hypotheses.FindingsThe authors found that R&D personnel’s knowledge sharing has a significant effect on their job performance. Furthermore, social skills significantly moderate the relationship between knowledge sharing and job performance.Originality/valueThis study addresses the existing literature’s limited understanding of the process nature of creativity and innovation by examining knowledge sharing as a personal engagement in the innovation process, which has a positive effect on job performance. The study also casts new light on the importance of social skills in fortifying personal engagement in the innovation process. The overall results will prove valuable in the selection of effective R&D personnel and the design of competency development programs for R&D organizations.
Firms’ money demand and monetary policy
Authors: Bafile Romina , Piergallini Alessandro 
Published: August 2017

AbstractStandard New Keynesian models for monetary policy analysis are ‘cashless’. When the nominal interest rate is the central bank's operating instrument, the LM equation is endogenous and, it is argued, can be ignored. The modern theoretical and quantitative debate on the importance of money for monetary policy conduct, however, overlooks firms’ money demand. Working in an otherwise canonical New Keynesian setup, we show that macroeconomic dynamics are critically affected by the firms’ money demand choice. Under the conventional Taylor‐rule framework, we prove that equilibrium determinacy may require either an active interest rate policy, overreacting to inflation, or a passive interest rate policy, underreacting to inflation, depending on the elasticity of production with respect to cash balances. We then develop a numerical analysis to evaluate our theoretical results. We find that macroeconomic stability is more likely to occur under an active, but not overly aggressive, monetary policy stance. We also examine the dynamic effects of forward‐looking feedback rules. We show that, in this policy regime, indeterminacy is likely to be induced by both active and passive rules, even for relatively low productivity effects of money.