bluuebunny/crossref_metadata_2025_split huggingface dataset:
Large-scale transport of PM2.5 in the lower troposphere during winter cold surges in China
Authors: Wang Jianjun , Zhang Meigen , Bai Xiaolin , Tan Hongjian , Li Sabrina , Liu Jiping , Zhang Rui , Wolters Mark A. , Qin Xiuyuan , Zhang Miming , Lin Hongmei , Li Yuenan , Li Jonathan , Chen Liqi 
Published: October 2017

AbstractA comprehensive investigation using the air quality network and meteorological data of China in 2015 showed that PM2.5 driven by cold surges from the ground level could travel up to 2000 km from northern to southern China within two days. Air pollution is more severe and prominent during the winter in north China due to seasonal variations in energy usage, trade wind movements, and industrial emissions. In February 2015, two cold surges traveling from north China caused a temporary increase in the concentration of PM2.5 in Shanghai. Subsequently, the concentration of PM2.5 in Xiamen increased to a high of 80 µg/m3, which is double the average PM2.5 concentration in Xiamen during the winter. This finding is a new long-range transport mechanism comparing to the well-established mechanism, with long-range transport more likely to occur in the upper troposphere than at lower levels. These observations were validated by results from the back trajectory analysis and the RAMS- CMAQ model. While wind speed was found to be a major facilitator in transporting PM2.5 from Beijing to Xiamen, more investigation is required to understand the complex relationship between wind speed and PM2.5 and how it moderates air quality in Beijing, Shanghai, and Xiamen.
Optimal $${\mathscr{P}}{\mathscr{T}}$$ -symmetric switch features exceptional point
Authors: Lupu Anatole , Konotop Vladimir V. , Benisty Henri 
Published: October 2017

AbstractWe consider the optimization problem of least energy-cost path in open systems that are described by non-Hermitian Hamiltonians. We apply it to find the optimal gain-loss profile for a non-uniform PT-symmetric coupler performing a binary transfer function. We bring evidence that the gain-loss profile fulfilling this requirement corresponds to a non-conventional situation where light intensity is conserved at every point along the PT-symmetric system. Besides, we find that the optimal profile corresponds to a practically important case of optical switching operation achieved with minimal amount of aggregate amplification level. We show that switching architectures using such type of gain-loss profiles are much more advantageous than conventional uniform PT-symmetric couplers in terms of gain and energy. Furthermore, this type of optimal profile turns out to be robust against fabrication imperfections. This opens new prospects for functional applications of PT-symmetric devices in photonics.
Gender-and lesion number-dependent difference in “atherogenic index of plasma” in Chinese people with coronary heart disease
Authors: Ni Wei , Zhou Zhenyu , Liu Tao , Wang Haoyu , Deng Jianping , Liu Xiaoyan , Xing Guoqiang 
Published: October 2017

AbstractFew studies has investigated the interrelationship between Atherogenic index of plasma (AIP) and coronary heart disease (CHD) especially in Asians. AIP is the logarithmically transformed ratio of triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C), and is thought to be associated with arteriosclerosis, hypertension, diabetes and cardiovascular diseases. Of the 463 patients from Central Hospital of Nanchong in 2011–2014 diagnosed with angiograms, 229 CHD (>50% stenosis in one or more arteries) and the rest 234 were the controls (maximum stenosis < 10% in any artery) according to the world health organization (who) diagnostic criteria. The multiple regression analysis showed that AIP was independently associated with CHD in men (odds ratio (OR) = 4.44, 95%CI 1.62–12.21, P = 0.004) after adjusting for age, body mass index (BMI), fasting blood glucose(FBG), homocysteine (Hcy), and smoking, but not in women (OR = 0.47, 95%CI 0.11–2.08, P = 0.318). Subgroup analysis showed that the significant difference in AIP between the CHD and the controls only exists in patients with multi-vessel lesions but not in those with single-vessel lesion. Further large-scale studies with balanced sex ratio and vessel lesion numbers should verify the present findings.
Broadband dual-anisotropic solid metamaterials
Authors: Cheng Yong , Zhou Xiaoming , Hu Gengkai 
Published: October 2017

AbstractWe have proposed solid elastic metamaterials with anisotropic stiffness and inertial mass simultaneously, denoted as the dual anisotropy, for the potential use of elastic wave controlling. The dual anisotropy has been designed weakly dispersive in a broad frequency range, wherein broadband anisotropic mass is achieved by employing the sliding-interface concept in fluid-solid composites. Results have been validated through the band-structure, effective-medium, and modal-field analyses. We have further found that the proposed solid metamaterial, when its shear stiffness is diminished until neglected, would reduce to the pentamode-inertial material model. This reduced model is the general form of mediums following transformation acoustic theory, which has been proved vital for acoustic wave controlling. Our studies are expected to pave a new route toward broadband acoustic and elastic wave controlling using dual-anisotropic solid metamaterials.
Specificity of surface EMG recordings for gastrocnemius during upright standing
Authors: Vieira Taian Martins , Botter Alberto , Muceli Silvia , Farina Dario 
Published: October 2017

AbstractThe relatively large pick-up volume of surface electrodes has for long motivated the concern that muscles other than that of interest may contribute to surface electromyograms (EMGs). Recent findings suggest however the pick-up volume of surface electrodes may be smaller than previously appreciated, possibly leading to the detection of surface EMGs insensitive to muscle activity. Here we combined surface and intramuscular recordings to investigate how comparably action potentials from gastrocnemius and soleus are represented in surface EMGs detected with different inter-electrode distances. We computed the firing instants of motor units identified from intramuscular EMGs detected from gastrocnemius and soleus while five participants stood upright. We used these instants to trigger and average surface EMGs detected from multiple skin regions along gastrocnemius. Results from 66 motor units (whereof 31 from gastrocnemius) revealed the surface-recorded amplitude of soleus action potentials was 6% of that of gastrocnemius and did not decrease for inter-electrode distances smaller than 4 cm. Gastrocnemius action potentials were more likely detected for greater inter-electrode distances and their amplitude increased steeply up to 5 cm inter-electrode distance. These results suggest that reducing inter-electrode distance excessively may result in the detection of surface EMGs insensitive to gastrocnemius activity without substantial attenuation of soleus crosstalk.
Structural variability and complexity of the giant Pithovirus sibericum particle revealed by high-voltage electron cryo-tomography and energy-filtered electron cryo-microscopy
Authors: Okamoto Kenta , Miyazaki Naoyuki , Song Chihong , Maia Filipe R. N. C. , Reddy Hemanth K. N. , Abergel Chantal , Claverie Jean-Michel , Hajdu Janos , Svenda Martin , Murata Kazuyoshi 
Published: October 2017

AbstractThe Pithoviridae giant virus family exhibits the largest viral particle known so far, a prolate spheroid up to 2.5 μm in length and 0.9 μm in diameter. These particles show significant variations in size. Little is known about the structure of the intact virion due to technical limitations with conventional electron cryo-microscopy (cryo-EM) when imaging thick specimens. Here we present the intact structure of the giant Pithovirus sibericum particle at near native conditions using high-voltage electron cryo-tomography (cryo-ET) and energy-filtered cryo-EM. We detected a previously undescribed low-density outer layer covering the tegument and a periodical structuring of the fibres in the striated apical cork. Energy-filtered Zernike phase-contrast cryo-EM images show distinct substructures inside the particles, implicating an internal compartmentalisation. The density of the interior volume of Pithovirus particles is three quarters lower than that of the Mimivirus. However, it is remarkably high given that the 600 kbp Pithovirus genome is only half the size of the Mimivirus genome and is packaged in a volume up to 100 times larger. These observations suggest that the interior is densely packed with macromolecules in addition to the genomic nucleic acid.
Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8
Authors: Kim Hyun-Taek , Lee Mi-Sun , Jeong Yun-Mi , Ro Hyunju , Kim Dong-Il , Shin Yong-Hwan , Kim Ji-Eun , Hwang Kyu-Seok , Choi Jung-Hwa , Bahn Minjin , Lee Jeong-Ju , Lee Sang H. , Bae Young-Ki , Lee Jin-Soo , Choi Joong-Kook , Kim Nam-Soon , Yeo Chang-Yeol , Kim Cheol-Hee 
Published: October 2017

AbstractWnt signaling controls critical developmental processes including tissue/body patterning. Here we report the identification of a novel regulator of Wnt signaling, OTTOGI (OTG), isolated from a large-scale expression screening of human cDNAs in zebrafish embryos. Overexpression of OTG in zebrafish embryos caused dorso-anteriorized phenotype, inhibited the expression of Wnt target genes, and prevented nuclear accumulation of β-catenin. Conversely, knockdown of zebrafish otg using specific antisense morpholino promoted nuclear accumulation of β-catenin and caused ventralization. However, OTG failed to rescue headless-like phenotype induced by inhibition of GSK-3β activity, suggesting that OTG acts upstream of GSK-3β. OTG bound specifically to Frizzled8 (Fz8) receptor and caused retention of Fz8 in the endoplasmic reticulum possibly by preventing N-linked glycosylation of Fz8. Taken together, our data indicate that OTG functions as a novel negative regulator of Wnt signaling during development by the modulation of cell surface expression of Fz receptor.
MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach
Authors: Cheung Chantal Hoi Yin , Hsu Chia-Lang , Chen Kai-Pu , Chong Siao-Ting , Wu Chang-Hsun , Huang Hsuan-Cheng , Juan Hsueh-Fen 
Published: October 2017

AbstractDNA replication control is vital for maintaining genome stability and the cell cycle, perhaps most notably during cell division. Malignancies often exhibit defective minichromosome maintenance protein 2 (MCM2), a cancer proliferation biomarker that serves as a licensing factor in the initiation of DNA replication. MCM2 is also known to be one of the ATPase active sites that facilitates conformational changes and drives DNA unwinding at the origin of DNA replication. However, the biological networks of MCM2 in lung cancer cells via protein phosphorylation remain unmapped. The RNA-seq datasets from The Cancer Genome Atlas (TCGA) revealed that MCM2 overexpression is correlated with poor survival rate in lung cancer patients. To uncover MCM2-regulated functional networks in lung cancer, we performed multi-dimensional proteomic approach by integrating analysis of the phosphoproteome and proteome, and identified a total of 2361 phosphorylation sites on 753 phosphoproteins, and 4672 proteins. We found that the deregulation of MCM2 is involved in lung cancer cell proliferation, the cell cycle, and migration. Furthermore, HMGA1S99 phosphorylation was found to be differentially expressed under MCM2 perturbation in opposite directions, and plays an important role in regulating lung cancer cell proliferation. This study therefore enhances our capacity to therapeutically target cancer-specific phosphoproteins.
Spin-polarised electrons in a one-magnet-only Mott spin junction
Authors: De Pietro L. , Bertolini G. , Peter Q. , Cabrera H. , Vindigni A. , Gürlü O. , Pescia D. , Ramsperger U. 
Published: October 2017

AbstractThe current flowing through a Mott spin junction depends on the relative spin orientation of the two ferromagnetic layers comprising the “source” and “drain” sides of the junction. The resulting current asymmetry is detected as giant or tunnelling magnetoresistance depending on whether the two ferromagnets are separated by a metal or an insulator. Based on the fundamental principles of reciprocity for spin-dependent electron scattering, one can envisage a one-magnet-only spin junction in which the source is non-magnetic, and the spin information is encoded by the spin polarisation of the electrons that have crossed or are backscattered from the drain magnetic layer. The practical significance of using an unpolarised source is that the state of the magnetic layer can be modified without affecting the process of probing it. Whether this reciprocity is realised in the actual junctions is not yet known. Here, we demonstrate a nano-sized, one-magnet-only Mott spin junction by measuring the finite spin polarisation of the backscattered electrons. Based on this finding, we conclude that since the junction acts as a spin filter, the magnetic layer must experience a spin transfer that could become detectable in view of the high current densities achievable in this technology.
Oyster reproduction is compromised by acidification experienced seasonally in coastal regions
Authors: Boulais Myrina , Chenevert Kyle John , Demey Ashley Taylor , Darrow Elizabeth S. , Robison Madison Raine , Roberts John Park , Volety Aswani 
Published: October 2017

AbstractAtmospheric carbon dioxide concentrations have been rising during the past century, leading to ocean acidification (OA). Coastal and estuarine habitats experience annual pH variability that vastly exceeds the magnitude of long-term projections in open ocean regions. Eastern oyster (Crassostrea virginica) reproduction season coincides with periods of low pH occurrence in estuaries, thus we investigated effects of moderate (pH 7.5, pCO2 2260 µatm) and severe OA (pH 7.1, pCO2 5584 µatm; and 6.7, pCO2 18480 µatm) on oyster gametogenesis, fertilization, and early larval development successes. Exposure at severe OA during gametogenesis caused disruption in oyster reproduction. Oogenesis appeared to be more sensitive compared to spermatogenesis. However, Eastern oyster reproduction was resilient to moderate OA projected for the near-future. In the context of projected climate change exacerbating seasonal acidification, OA of coastal habitats could represent a significant bottleneck for oyster reproduction which may have profound negative implications for coastal ecosystems reliant on this keystone species.
Synthetic nanocomposite MgH2/5 wt. % TiMn2 powders for solid-hydrogen storage tank integrated with PEM fuel cell
Authors: El-Eskandarany M. Sherif , Shaban Ehab , Aldakheel Fahad , Alkandary Abdullah , Behbehani Montaha , Al-Saidi M. 
Published: October 2017

AbstractStoring hydrogen gas into cylinders under high pressure of 350 bar is not safe and still needs many intensive studies dedic ated for tank’s manufacturing. Liquid hydrogen faces also severe practical difficulties due to its very low density, leading to larger fuel tanks three times larger than traditional gasoline tank. Moreover, converting hydrogen gas into liquid phase is not an economic process since it consumes high energy needed to cool down the gas temperature to −252.8 °C. One practical solution is storing hydrogen gas in metal lattice such as Mg powder and its nanocomposites in the form of MgH2. There are two major issues should be solved first. One related to MgH2 in which its inherent poor hydrogenation/dehydrogenation kinetics and high thermal stability must be improved. Secondly, related to providing a safe tank. Here we have succeeded to prepare a new binary system of MgH2/5 wt. % TiMn2 nanocomposite powder that show excellent hydrogenation/dehydrogenation behavior at relatively low temperature (250 °C) with long cycle-life-time (1400 h). Moreover, a simple hydrogen storage tank filled with our synthetic nanocomposite powders was designed and tested in electrical charging a battery of a cell phone device at 180 °C through a commercial fuel cell.
Environmental and behavioral changes may influence the exposure of an Arctic apex predator to pathogens and contaminants
Authors: Atwood Todd C. , Duncan Colleen , Patyk Kelly A. , Nol Pauline , Rhyan Jack , McCollum Matthew , McKinney Melissa A. , Ramey Andrew M. , Cerqueira-Cézar Camila K. , Kwok Oliver C. H. , Dubey Jitender P. , Hennager Steven 
Published: October 2017

AbstractRecent decline of sea ice habitat has coincided with increased use of land by polar bears (Ursus maritimus) from the southern Beaufort Sea (SB), which may alter the risks of exposure to pathogens and contaminants. We assayed blood samples from SB polar bears to assess prior exposure to the pathogensBrucellaspp.,Toxoplasma gondii, Coxiella burnetii,Francisella tularensis, andNeospora caninum, estimate concentrations of persistent organic pollutants (POPs), and evaluate risk factors associated with exposure to pathogens and POPs. We found that seroprevalence ofBrucellaspp. andT. gondiiantibodies likely increased through time, and provide the first evidence of exposure of polar bears toC. burnetii,N. caninum, andF. tularensis. Additionally, the odds of exposure toT. gondiiwere greater for bears that used land than for bears that remained on the sea ice during summer and fall, while mean concentrations of the POP chlordane (ΣCHL) were lower for land-based bears. Changes in polar bear behavior brought about by climate-induced modifications to the Arctic marine ecosystem may increase exposure risk to certain pathogens and alter contaminant exposure pathways.
Precise measurement of hyperfine structure in the 3S1/2 state of 7Li
Authors: Kumar Pushpander , Natarajan Vasant 
Published: October 2017

AbstractWe report a precise measurement of hyperfine structure in the 3S1/2 state of the odd isotope of Li, namely 7Li. The state is excited from the ground 2S1/2 state (which has the same parity) using two single-photon transitions via the intermediate 2P3/2 state. The value of the hyperfine constant we measure is A = 93.095(52) MHz, which resolves two discrepant values reported in the literature measured using other techniques. Our value is also consistent with theoretical calculations.
Gene delivery of hypoxia-inducible VEGF targeting collagen effectively improves cardiac function after myocardial infarction
Authors: Xia Jing-Bo , Wu Hai-Yan , Lai Bing-Lin , Zheng Li , Zhou Deng-Cheng , Chang Zao-Shang , Mao Cheng-Zhou , Liu Guang-Hui , Park Kyu-Sang , Zhao Hui , Kim Soo-Ki , Song Guo-Hua , Cai Dong-Qing , Qi Xu-Feng 
Published: October 2017

AbstractVascular endothelial growth factor (VEGF) plays important roles in improvement of cardiac function following myocardial infarction (MI). However, the lack of a steerable delivery system of VEGF targeting the infarcted myocardium reduces the therapeutic efficacy and safety. Here, we constructed a series of lentiviral vector systems which could express a fusion protein consisted of a collagen-binding domain (CBD) and hVEGF (CBDhVEGF), under the control of 5HRE-hCMVmp (5HRE), the hypoxia-inducible promoter consists of five copies of the hypoxia-responsive element (HRE) and a human cytomegalovirus minimal promoter (hCMVmp). We demonstrated that 5HRE has the comparable ability to strongly drive CBDhVEGF under hypoxic condition as the ubiquitous CMV promoter, but it can hardly drive target gene under normoxic condition. 5HRE-drived CBDhVEGF specifically bound to type I collagen and significantly promoted the viability of HUVEC cells. Moreover, after injection of lentivirus into heart of mouse with MI, CBDhVEGF was mainly retained in infarcted myocardium where containing rich collagen and significantly improved angiogenesis and cardiac function when compared with hVEGF. Moreover, CBDhVEGF mediated by lentivirus has little leakage from infarcted zone into blood than hVEGF. Taken together, our results indicate that 5HRE-CBDhVEGF lentiviral vector system could improve cardiac function in the collagen-targeting and hypoxia-inducible manners.
Synthesis of single-phase L10-FeNi magnet powder by nitrogen insertion and topotactic extraction
Authors: Goto Sho , Kura Hiroaki , Watanabe Eiji , Hayashi Yasushi , Yanagihara Hideto , Shimada Yusuke , Mizuguchi Masaki , Takanashi Koki , Kita Eiji 
Published: October 2017

AbstractTetrataenite (L10-FeNi) is a promising candidate for use as a permanent magnet free of rare-earth elements because of its favorable properties. In this study, single-phase L10-FeNi powder with a high degree of order was synthesized through a new method, nitrogen insertion and topotactic extraction (NITE). In the method, FeNiN, which has the same ordered arrangement as L10-FeNi, is formed by nitriding A1-FeNi powder with ammonia gas. Subsequently, FeNiN is denitrided by topotactic reaction to derive single-phase L10-FeNi with an order parameter of 0.71. The transformation of disordered-phase FeNi into the L10 phase increased the coercive force from 14.5 kA/m to 142 kA/m. The proposed method not only significantly accelerates the development of magnets using L10-FeNi but also offers a new synthesis route to obtain ordered alloys in non-equilibrium states.
miR-29b regulates expression of collagens I and III in chondrogenically differentiating BMSC in an osteoarthritic environment
Authors: Mayer Ute , Benditz Achim , Grässel Susanne 
Published: October 2017

AbstractOsteoarthritis (OA) is characterized by a slowly progressing, irreversible loss of articular cartilage. Tissue engineering approaches for cartilage regeneration include stem cell-based strategies but not much is known about their repair capacity in an OA microenvironment. The aim of the present study was to identify factors regulating collagen expression during chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSC) in an OA microenvironment. Coculture with OA cartilage induced miR-29b expression in BMSC which inhibited collagen I and III expression. Elevated miR-29b expression resulted in higher caspase 3/7 activity and promoted apoptosis of BMSC in part by directly inhibiting the anti-apoptotic proteins Bcl-2 and Mcl-1. Stimulation with IFN-γ induced miR-29b expression in BMSC. Our results suggest that miR-29b affects BMSC-based OA cartilage regeneration because expression of collagen III, mainly produced by undifferentiated BMSC, and collagen I, a marker for dedifferentiated chondrocytes, are inhibited by miR-29b thus influencing composition of the newly formed ECM. This might be critical to avoid formation of inferior fibrocartilage instead of hyaline cartilage. Furthermore, higher miR-29b expression promotes apoptosis either preventing excessive cell growth or reducing the number of BMSC undergoing chondrogenesis. Thus, miR-29b has both supportive but possibly also unfavourable effects on BMSC-based OA cartilage regeneration.