bluuebunny/crossref_metadata_2025_split huggingface dataset:
Delivering Intensive Rehabilitation in Stroke: Factors Influencing Implementation
Authors: Connell Louise A , Klassen Tara K , Janssen Jessie , Thetford Clare , Eng Janice J 
Published: January 2018

Abstract

Background
The evidence base for stroke rehabilitation recommends intensive and repetitive task-specific practice, as well as aerobic exercise. However, translating these -evidence-based interventions from research into clinical practice remains a major -challenge.

Objective
The objective of this study was to investigate factors influencing implementation of higher-intensity activity in stroke rehabilitation settings.

Design
This qualitative study used a cross-sectional design.

Methods
Semi-structured interviews were conducted with rehabilitation therapists from 4 sites across 2 Canadian provinces who had experience in delivering a higher-intensity intervention as part of a clinical trial (Determining Optimal post-Stroke Exercise [DOSE]). An interview guide was developed, and data were analyzed using implementation frameworks.

Results
Fifteen therapists were interviewed before data saturation was reached. Therapists and patients generally had positive experiences regarding high-intensity interventions. However, therapists felt they would adapt the protocol to accommodate their beliefs about ensuring movement quality. The requirement for all patients to have a graded exercise test and the use of sensors (eg, heart rate monitors) gave therapists confidence to push patients harder than they normally would. Paradoxically, a system that enables routine graded exercise testing and the availability of staff and equipment contribute challenges for implementation in everyday practice.

Conclusions
Even therapists involved in delivering a high-intensity intervention as part of a trial wanted to adapt it for clinical practice; therefore, it is imperative that researchers are explicit regarding key intervention components and what can be adapted to help ensure implementation fidelity. Changes in therapists’ beliefs and system-level changes (staffing and resources) are likely necessary to facilitate higher-intensity rehabilitation in practice.
First Safety and Performance Evaluation of T45K, a Self-Assembling Peptide Barrier Hemostatic Device, After Skin Lesion Excision
Authors: Rahmani George , Prats Jayne , Norchi Terrence , Kates Steven , McInerney Veronica , Woods Jack , Kelly Jack 
Published: January 2018

BACKGROUND
The self-assembling peptide barrier T45K (SAPB-T45K) is an oligopeptide that rapidly forms a biocompatible hemostatic barrier when applied to wounds.

OBJECTIVE
Evaluate safety and performance of SAPB-T45K in cutaneous surgery.

MATERIALS AND METHODS
In this single-blind study, after sequential shave excision of 2 lesions, wounds were randomized (intrapatient) to SAPB-T45K or control treatment. Safety was assessed at treatment, Day 7, and Day 30. Performance was evaluated using time to hemostasis (TTH) and ASEPSIS wound scores, with a subgroup analysis for patients with or without antiplatelet therapy.

RESULTS
Each of 46 patients (10 [22%] with antiplatelet therapy) received randomized SAPB-T45K or control treatment for 2 wounds. Safety assessments were similar, and ASEPSIS scores reflected normal healing in both wound groups. SAPB-T45K demonstrated significantly faster median TTH (24.5 [range, 7–165] seconds) compared with control (44 [10–387] seconds), for a 41% median TTH reduction (18 [95% confidence interval, 7–35] seconds, p < .001). SAPB-T45K provided an identical median TTH of 24 seconds, regardless of antiplatelet therapy. Control median TTH was 90 and 40 seconds for patients taking or not taking antiplatelet therapy, respectively.

CONCLUSIONS
SAPB-T45K provided significantly faster median TTH versus control, especially with antiplatelet therapy, and safety profiles were similar.
From 1D sequence to 3D chromatin dynamics and cellular functions: a phase separation perspective
Authors: Liu Sirui , Zhang Ling , Quan Hui , Tian Hao , Meng Luming , Yang Lijiang , Feng Huajie , Gao Yi Qin 
Published: January 2018

AbstractThe high-order chromatin structure plays a non-negligible role in gene regulation. However, the mechanism for the formation of different chromatin structures in different cells and the sequence dependence of this process remain to be elucidated. As the nucleotide distributions in human and mouse genomes are highly uneven, we identified CGI forest and prairie genomic domains based on CGI density, which better segregates genomic elements along the genome than GC content. The genome is then divided into two sequentially, epigenetically, and transcriptionally distinct regions. These two types of megabase-sized domains spatially segregate, but to a different extent in different cell types. Overall, the forests and prairies gradually segregate from each other in development, differentiation, and senescence. The multi-scale forest-prairie spatial intermingling is cell-type specific and increases in differentiation, thus helps define the cell identity. We propose that the phase separation of the 1D mosaic sequence in space, serving as a potential driving force, together with cell type specific epigenetic marks and transcription factors, shapes the chromatin structure in different cell types and renders them distinct genomic properties. The mosaicity of the genome manifested in terms of alternative forests and prairies of a species could be related to its biological processes such as differentiation, aging and body temperature control.
The biogenesis of extracellular vesicles fromStaphylococcus aureusand their application as a novel vaccine platform
Authors: Wang Xiaogang , Weidenmaier Christopher , Lee Jean C. 
Published: January 2018

AbstractGram-positive bacteria secrete extracellular vesicles (EVs) that package diverse bacterial antigens and play key roles in bacterial pathogenesis. However, the mechanisms underlying EV production in Gram-positive bacteria are poorly understood. We purified and characterized EVs from a community-associated methicillin-resistantStaphylococcus aureusisolate (USA300) and investigated mechanisms underlying EV production. Native EVs contained 165 proteins, including cytosolic, surface, and secreted proteins, autolysins, and numerous cytolysins. Staphylococcal alpha-type phenol-soluble modulins (surfactant-like peptides) promoted EV biogenesis, presumably by acting at the cytoplasmic membrane, whereas peptidoglycan crosslinking and autolysin activity were found to increase EV production by altering the permeability of the staphylococcal cell wall. To address the immunogenicity of EVs, we created engineered EVs (eng-EVs) by expressing detoxified proteins HlaH35Land LukE in EVs generated from a nontoxicS. aureus ΔagrΔspamutant. Eng-EVs exhibited no cytotoxicity in vitro, and mice immunized with the eng-EVs produced toxin-neutralizing antibodies and showed reduced lethality in a mouse sepsis model. Our study reveals novel mechanisms underlyingS. aureusEV production and highlights the usefulness of EVs as a novelS. aureusvaccine platform.
Parp3 promotes long-range end-joining in murine cells
Authors: Layer Jacob V. , Patrick Cleary J. , Brown Alexander J. , Stevenson Kristen E. , Morrow Sara N. , Van Scoyk Alexandria , Blasco Rafael B. , Karaca Elif , Meng Fei-Long , Frock Richard L. , Tivey Trevor , Kim Sunhee , Fuchs Hailey , Chiarle Roberto , Alt Frederick W. , Roberts Steven A. , Weinstock David M. , Day Tovah A. 
Published: January 2018

AbstractChromosomal rearrangements, including translocations, are early and essential events in the formation of many tumors. Previous studies that defined the genetic requirements for rearrangement formation have identified differences between murine and human cells, most notably in the role of classical‐ and alternative-nonhomologous end joining factors (NHEJ). We reported that poly(ADP)ribose polymerase 3 (PARP3) promotes chromosomal rearrangements induced by endonucleases in multiple human cell types. In contrast to c-NHEJ factors, we show here that Parp3 also promotes rearrangements in murine cells, including translocations in murine embryonic stem cells (mESCs), class switch recombination in primary B cells and inversions in tail fibroblasts that generate Eml4-Alk fusions. In mESCs, Parp3-deficient cells had shorter deletion lengths at translocation junctions. This was corroborated using next-generation sequencing of Eml4-Alk junctions in tail fibroblasts and is consistent with a role for Parp3 in promoting the processing of DNA double-strand breaks. We confirmed a previous report that Parp1 also promotes rearrangement formation. In contrast with Parp3, rearrangement junctions in the absence of Parp1 had longer deletion lengths, suggesting Parp1 may suppress DSB processing. Together, these data indicate that Parp3 and Parp1 promote rearrangements with distinct phenotypes.
A series-parallel inventory-redundancy green allocation system using a max-min approach via the interior point method
Authors: Niknamfar Amir Hossein , Niaki Seyed Armin Akhavan , karimi Marziyeh 
Published: January 2018

Purpose
The purpose of this study is to develop a novel and practical series-parallel inventory-redundancy allocation system in a green supply chain including a single manufacturer and multiple retailers operating in several positions without any conflict of interests. The manufacturer first produces multi-product and then dispatches them to the retailers at different wholesale prices based on a common replenishment cycle policy. In contrast, the retailers sell the purchased products to customers at different retail prices. In this way, the manufacturer encounters a redundancy allocation problem (RAP), in which the solution subsequently enhances system production reliability. Furthermore, to emphasize on global warming and human health concerns, this paper pays attention both the tax cost of industrial greenhouse gas (GHG) emissions of all produced products and the limitation for total GHG emissions.

Design/methodology/approach
The manufacturer intends not only to maximize the total net profit but also to minimize the mean time to failure of his production system using a RAP. To achieve these objectives, the max-min approach associated with the solution method known as the interior point method is utilized to maximize the minimum (the worst) value of the objective functions. Finally, numerical experiments are presented to further demonstrate the applicability of the proposed methodology. Sensitivity analysis on the green supply chain approach is also performed to obtain more insight.

Findings
The computational results showed that increasing the number of products and retailers might lead into a substantial increase in the total net profit. This indicated that the manufacturer would feel adding a new retailer to the green supply chain strongly. Moreover, an increase in the number of machines provides significant improvement in the reliability of the production system. Furthermore, the results of the performed sensitivity analysis on the green approach indicated that increasing the number of machines has a substantial impact on both the total net profit and the total tax cost. In addition, not only the proposed green supply chain was more efficient than the supply chain without green but also the proposed green supply chain was very sensitive to the tax cost of GHG emission rather than the number of machines.

Originality/value
In summary, the motivations are as follows: the development of a bi-objective series-parallel inventory-RAP in a green supply chain; proposing a hybrid inventory-RAP; and considering the interior point solution method. The novel method comes from both theoretical and experimental techniques. The paper also has industrial applications. The advantage of using the proposed approach is to generate additional opportunities and cost effectiveness for businesses and companies that operate utilizing the green supply chain under an inventory model.
Applying EEG in consumer neuroscience
Authors: Lin Meng-Hsien (Jenny) , Cross Samantha N.N. , Jones William J. , Childers Terry L. 
Published: January 2018

PurposeThis paper aims to review past papers focused on understanding consumer-related topics in marketing and related interdisciplinary fields to demonstrate the applications of electroencephalogram (EEG) in consumer neuroscience.Design/methodology/approachIn addition to the review of papers using EEG to study consumer cognitive processes, the authors also discuss relevant decisions and considerations in conducting event-related potential (ERP) studies. Further, a framework proposed by Plassmann et al. (2015) was used to discuss the applications of EEG in marketing research from papers reviewed.FindingsThis paper successfully used Plassmann et al.’s (2015) framework to discuss five applications of neuroscience to marketing research. A review of growing EEG studies in the field of marketing and other interdisciplinary fields reveals the advantages and potential of using EEG in combination with other methods. This calls for more research using such methods.Research limitations/implicationsA technical overview of ERP-related terminology provides researchers with a background for understanding and reviewing ERP studies. A discussion of method-related considerations and decisions provides marketing researchers with an introduction to the method and refers readers to relevant literature.Practical implicationsThe marketing industry has been quick to adopt cutting edge technology, including EEG, to understand and predict consumer behavior for the purpose of improving marketing practices. This paper connects the academic and practitioner spheres by presenting past and potential EEG research that can be translatable to the marketing industry.Originality/valueThe authors review past literature on the use of EEG to study consumer-related topics in marketing and interdisciplinary fields, to demonstrate its advantages over-traditional methods in studying consumer-relevant behaviors. To foster increasing use of EEG in consumer neuroscience research, the authors further provide technical and marketing-specific considerations for both academic and market researchers. This paper is one of the first to review past EEG papers and provide methodological background insights for marketing researchers.
Manager-employee psychological contracts: enter the smartphone
Authors: Obushenkova Elena , Plester Barbara , Haworth Nigel 
Published: January 2018

PurposeThe purpose of this paper is to investigate how company-provided smartphones and user-device attachment influence the psychological contract between employees and managers in terms of connectivity expectations and outcomes.Design/methodology/approachData were collected using qualitative semi-structured interviews with 28 participants from four organizations.FindingsThe study showed that when organizations provide smartphones to their employees, the smartphones become a part of the manager-employee relationship through user-device attachment and this can change connectivity expectations for both employees and managers.Research limitations/implicationsDue to participant numbers, these findings may not be generalizable to all employees and managers who receive company smartphones. However, the authors have important implications for theory. The smartphone influence on the psychological climate and its role as a signal for workplace expectations suggest that mobile information and communication technology devices must be considered in psychological contract formation, development, change and breach.Practical implicationsThe perceived expectations can lead to hyper-connectivity which can have a number of negative performance and health outcomes such as technostress, burnout, absenteeism and work-life conflict.Social implicationsSmartphone usage and user-device attachment have the potential to redefine human relations by encouraging and normalizing hyper-connected relationships.Originality/valueThis study makes an original contribution to psychological contract theory by showing that smartphones and attachment to these devices create perceived expectations to stay connected to work and create negative outcomes, especially for managers.
Exploring the organizational drivers of sexual harassment
Authors: Ollo-López Andrea , Nuñez Imanol 
Published: January 2018

PurposeThe purpose of this paper is to investigate and identify the organizational drivers of sexual harassment (SH).Design/methodology/approachDrawing on data from a representative sample of workers in Spain, this paper sheds light on the likelihood of SH influenced by: organizational environment and climate, organizational forms and structure, and job design parameters.FindingsThe analysis reveals that organizational climates where negative behaviors are tolerated are particularly advantageous for harassers. Furthermore, the profile of the victims of SH is that they work in isolation, are contracted through employment agencies, are not given training opportunities, and have low status in the firm. Analysis also reveals, however, that firms can reduce the risk of SH by empowering jobs and improving time flexibility.Research limitations/implicationsThe use of secondary data implies some constrains: the type of measure and the failure to control for the role of SH perpetrators.Practical implicationsManagers should adopt some organizational policies, such as empower job or improve time flexibility, since they reduce the risk of SH.Originality/valueThis paper identifies some objective organizational settings where SH is more likely and provides some easy to apply solutions to prevent it.
Creating a longitudinal, data-driven 3D model of change over time in a postindustrial landscape using GIS and CityEngine
Authors: Arnold John David McEwen , Lafreniere Don 
Published: January 2018

Purpose
The purpose of this paper is to create a longitudinal data-driven model of change over time in a postindustrial landscape, using the “Copper Country” of Michigan’s Upper Peninsula as a case study. The models resulting from this project will support the heritage management and public education goals of the contemporary communities and Keweenaw National Historical Park that administer this nationally significant mining region through accessible, engaging, and interpretable digital heritage.

Design/methodology/approach
The paper applies Esri’s CityEngine procedural modeling software to an existing historical big data set. The Copper Country Historical Spatial Data Infrastructure, previously created by the HESA lab, contains over 120,000 spatiotemporally specific building footprints and other built environment variables. This project constructed a pair of 3D digital landscapes comparing the built environments of 1917 and 1949, reflecting the formal and functional evolution of several of the most important copper mining, milling, and smelting districts of Michigan’s Keweenaw Peninsula.

Findings
This research discovered that CityEngine, while intended for rapid 3D modeling of the contemporary urban landscape, was sufficiently robust and flexible to be applied to modeling serial historic industrial landscapes. While this novel application required some additional coding and finish work, by harnessing this software to existing big data sets, 48,000 individual buildings were rapidly visualized using several key variables.

Originality/value
This paper presents a new and useful application of an existing 3D modeling software, helping to further illuminate and inform the management and conservation of the rich heritage of this still-evolving postindustrial landscape.
Perfect bodies
Authors: Strubel Jessica , Petrie Trent A. 
Published: January 2018

Purpose
The purpose of this paper is to investigate how dimensions of body image relate to product involvement among gay men.

Design/methodology/approach
A survey consisting of body image and product involvement measures was administered to 147 self-identified gay men. Multiple regression was used to examine the relations of the significant body image variables to each of the consumer behavior outcomes in separate analyses.

Findings
The more the men were behaviorally invested in their appearance predicted a higher frequency of shopping each month for apparel and grooming-related products. The stronger the men’s psychological drive to have a lean body and the more they focused on their appearance and invested in their looks, the more likely they were to view apparel as important to them. The more psychologically and behaviorally involved the gay men reported being with their appearance, the more importance they gave to grooming-related products.

Research limitations/implications
The sample was drawn primarily from a college population, limiting findings to this age cohort.

Practical implications
The findings of the current research demonstrate the importance of appearance management products to the gay market, where commodities are often used to enhance or maintain a perceived self-image. Retailers can use this information to establish appropriate service options and effective marketing initiatives.

Originality/value
This study replicated others that have investigated gay men’s involvement in consumer products. However, the current study looked at the relationship between involvement and body image.
Fashion and women’s self-concept: a typology for self-fashioning using clothing
Authors: McNeill Lisa S. 
Published: January 2018

Purpose
An individual’s identity is defined in the role that they devise for themselves, based on social positions. Examining identity motives can help in understanding what influences one to take on a particular role. Self-esteem is one of the major motivational drivers in determining the role that an individual takes on. Individuals, through self-presentation, are said to be motivated to control the impressions others form of them. In this way, self-concept and fashion innovativeness are linked – with prior research suggesting that those with high levels of fashion innovativeness are also those with a strong sense of self. Where a gap remains, however, in exploring the direction of the relationship between self-concept and being more innovative and fashionable in clothing choices, as well as how individuals reflexively judge their own fashion choices against their perception of others – e.g. can you force yourself to be a fashion leader? The paper aims to discuss these issues.

Design/methodology/approach
This study takes a lived experience approach to examine fashion as a tool in establishing social hierarchies amongst women. The study uses depth interviews with ten women to explore the developed self-concept of women actively engaged with fashion consumption.

Findings
The research presents a typology of fashion identities, exploring notions of security, dominance and innovativeness in self-fashioning using clothing.

Research limitations/implications
The research is exploratory, and limited to a sample of ten women. However, the study offers a number of key findings to drive future research in this area.

Practical implications
The research finds that both security of self-concept, in relation to fashion and general self-esteem, as well as insecurity, can motivate women towards fashion independence. This suggests that identity-based marketing is likely to be more successful than lifestyle-based marketing, when selling women’s fashion clothing.

Social implications
In prior research, self-concept and fashion innovativeness are linked – with prior research suggesting that those with high levels of fashion innovativeness are also those with a strong sense of self. This study finds that those with an insecure sense of self may also exhibit fashion independence, using fashion to acquire social capital.

Originality/value
This paper illustrates the concept that, unlike previous notions of fashion independence and engagement with fashion, these fashion-involved categorisations of behaviour are not always driven by sophistication, confidence, creativity and low fear of risk. Instead, this study has shown that fashion innovativeness can be motivated by an overarching fear of the outcomes of being judged unfashionable.