bluuebunny/crossref_metadata_2025_split huggingface dataset:
Going Modern: The tourist experience at the seaside and hill resorts in late Qing and Republican China
Authors: BARRENTO ANTÓNIO EDUARDO HAWTHORNE 
Published: November 2017

AbstractA network of seaside and hill resorts created by foreigners gradually took shape in China during the late Qing and Republican periods. Such places were both a touristic novelty in China and the focal point of a type of tourist experience that was modern in a variety of ways. This article examines tourist accounts, tourist guidance material, and other sources, in an attempt to understand the major habits, norms, perceptions, and meanings of tourism to the seaside and hill resorts as a new type of tourism in China, from its inception to the downfall of the Nationalist government in 1949. For this purpose, it explores three aspects that were central to resort tourism: its strong association with an idea of refuge, its identification as an ideal experience, and its important physical component. While the article aims at an overall analysis of this new element of tourist culture in China, it also seeks to locate it within the wider contexts of tourist culture and of the broad motivations and anxieties of this period.
Cattle and rainfall affect tick abundance in central Kenya
Authors: KEESING FELICIA , OSTFELD RICHARD S. , YOUNG TRUMAN P. , ALLAN BRIAN F. 
Published: November 2017

SUMMARYEast Africa is a global hot spot for the diversity of ixodid ticks. As ectoparasites and as vectors of pathogens, ticks negatively affect the well-being of humans, livestock and wildlife. To prevent tick infestations, livestock owners and managers typically treat livestock with acaricides that kill ticks when they attempt to feed on livestock hosts. Because of the costs of preventing and mitigating tick parasitism, predicting where and when ticks will be abundant is an important challenge in this region. We used a 7-year monthly record of tick abundance on large experimental plots to assess the effects of rainfall, wildlife and cattle on larvae, nymphs and adults of two common tick species, Rhipicephalus pulchellus and Rhipicephalus praetextatus. Nymphal and adult ticks were more abundant when there had been high cumulative rainfall in the prior months. They were less abundant when cattle were present than when only large wild mammals were. Larval abundance was not affected by the presence of cattle, and larvae did not appear to be sensitive to rainfall in prior months, though they were less abundant in our surveys when rainfall was high in the sampling month. The challenges of managing ticks in this region are being exacerbated rapidly by changes in rainfall patterns wrought by climate change, and by overall increases in livestock, making efforts to predict the impacts of these drivers all the more pressing.
DNA barcoding ofCryptosporidium
Authors: ŠLAPETA JAN 
Published: November 2017

SUMMARYCryptosporidiumspp. (Apicomplexa) causing cryptosporidiosis are of medical and veterinary significance. The genusCryptosporidiumhas benefited from the application of what is considered a DNA-barcoding approach, even before the term ‘DNA barcoding’ was formally coined. Here, the objective to define the DNA barcode diversity ofCryptosporidiuminfecting mammals is reviewed and considered to be accomplished. Within theCryptosporidiumliterature, the distinction between DNA barcoding and DNA taxonomy is indistinct. DNA barcoding and DNA taxonomy are examined using the latest additions to the growing spectrum of namedCryptosporidiumspecies and within-species and between-species identity is revisited. Ease and availability of whole-genome DNA sequencing of the relatively smallCryptosporidiumgenome offer an initial perspective on the intra-host diversity. The opportunity emerges to apply a metagenomic approach to purified field/clinicalCryptosporidumisolates. The outstanding question remains a reliable definition ofCryptosporidiumphenotype. The complementary experimental infections and metagenome approach will need to be applied simultaneously to addressCryptosporidiumphenotype with carefully chosen clinical evaluations enabling identification of virulence factors.
The Arabic of the Islamic conquests: notes on phonology and morphology based on the Greek transcriptions from the first Islamic century
Authors: Al-Jallad Ahmad 
Published: November 2017

AbstractThis paper attempts to reconstruct aspects of the phonology and morphology of the Arabic of the Islamic conquests on the basis of Greek transcriptions in papyri of the first Islamic century. The discussion includes phonemic and allophonic variation in consonants and vowels, and nominal morphology. The essay concludes with a discussion on possible Aramaic and South Arabian influences in the material, followed by a short appendix with remarks on select Arabic terms from the pre-Islamic papyri.
Two Iranian loanwords in Syriac
Authors: Sims-Williams Nicholas 
Published: November 2017

AbstractThis article discusses two Syriac words which have been understood in many different ways by both ancient and modern scholars. The translations and etymologies previously proposed are evaluated and new explanations are offered, according to which both words,sāsgaunā“red” andsyānqā“hemi-drachm”, are loanwords from Middle Persian, though unattested in that language.
Capturing The Ancient Animal: Human/Animal Studies and the Classics
Authors: Kindt Julia 
Published: November 2017

AbstractThis article reviews several books published since the turn of the millennium that explore the role and representation of animals in different areas of ancient Greek and Roman culture. Despite differences in focus and outlook, these books herald the arrival within classical studies of the questions, concepts and methods of human/animal studies as an emerging field of enquiry. This article takes their publication as an opportunity to take stock and to outline the relationship between these disciplines. I explore how current research on ancient animals resonates both in existing debates in classical scholarship and within the context of the larger interdisciplinary debate. I also suggest how this debate can point to productive avenues for further enquiry in classical studies. More specifically, I argue that the interdisciplinary debate sets an important agenda, which should be embraced more fully by classical studies. Classical scholarship on the role, function and perception of animals in different areas of ancient Greek and Roman life can provide important insights into one aspect of the heritage – Western conceptions of humanity and the place of the animal within it – which has not yet received the attention it deserves. I conclude that classical scholarship can make a significant contribution to the interdisciplinary debate, helping it deliver on its stated goal of examining and challenging Western concepts of self, as well as the ideologies of ‘the other’ underpinning them.
Milk products in the dietary management of childhood undernutrition – a historical review
Authors: Scherbaum Veronika , Srour M. Leila 
Published: November 2017

AbstractThe present narrative review outlines the use of milk products in infant and young child feeding from early history until today and illustrates how research findings and technical innovations contributed to the evolution of milk-based strategies to combat undernutrition in children below the age of 5 years. From the onset of social welfare initiatives, dairy products were provided by maternal and child health services to improve nutrition. During the last century, a number of aetiological theories on oedematous forms of undernutrition were developed and until the 1970s the dogma of protein deficiency was dominant. Thereafter, a multifactorial concept gained acceptance and protein quality was emphasised. During the last decades, research findings demonstrated that the inclusion of dairy products in the management of severe acute malnutrition is most effective. For children suffering from moderate acute malnutrition the evidence for the superiority of milk-based diets is less clear. There is an unmet need for evaluating locally produced milk-free alternatives at lower cost, especially in countries that rely on imported dairy products. New strategies for the dietary management of childhood undernutrition need to be developed on the basis of research findings, current child feeding practices, socio-cultural conditions and local resources. Exclusive and continued breast-feeding supported by community-based nutrition programmes using optimal combinations of locally available complementary foods should be compared with milk product-based interventions.
Service user and caregiver involvement in mental health system strengthening in low- and middle-income countries: a cross-country qualitative study
Authors: Lempp H. , Abayneh S. , Gurung D. , Kola L. , Abdulmalik J. , Evans-Lacko S. , Semrau M. , Alem A. , Thornicroft G. , Hanlon C. 
Published: November 2017

Aims.The aims of this paper are to: (i) explore the experiences of involvement of mental health service users, their caregivers, mental health centre heads and policy makers in mental health system strengthening in three low- and middle-income countries (LMICs) (Ethiopia, Nepal and Nigeria); (ii) analyse the potential benefits and barriers of such involvement; and (iii) identify strategies required to achieve greater service user and caregiver participation.Methods.A cross-country qualitative study was conducted, interviewing 83 stakeholders of mental health services.Results.Our analysis showed that service user and caregiver involvement in the health system strengthening process was an alien concept for most participants. They reported very limited access to direct participation. Stigma and poverty were described as the main barriers for involvement. Several strategies were identified by participants to overcome existing hurdles to facilitate service user and caregiver involvement in the mental health system strengthening process, such as support to access treatment, mental health promotion and empowerment of service users. This study suggests that capacity building for service users, and strengthening of user groups would equip them to contribute meaningfully to policy development from informed perspectives.Conclusion.Involvement of service users and their caregivers in mental health decision-making is still in its infancy in LMICs. Effective strategies are required to overcome existing barriers, for example making funding more widely available for Ph.D. studies in participatory research with service users and caregivers to develop, implement and evaluate approaches to involvement that are locally and culturally acceptable in LMICs.
NOG1 increases grain production in rice
Authors: Huo Xing , Wu Shuang , Zhu Zuofeng , Liu Fengxia , Fu Yongcai , Cai Hongwei , Sun Xianyou , Gu Ping , Xie Daoxin , Tan Lubin , Sun Chuanqing 
Published: November 2017

AbstractDuring rice domestication and improvement, increasing grain yield to meet human needs was the primary objective. Rice grain yield is a quantitative trait determined by multiple genes, but the molecular basis for increased grain yield is still unclear. Here, we show that NUMBER OF GRAINS 1 (NOG1), which encodes an enoyl-CoA hydratase/isomerase, increases the grain yield of rice by enhancing grain number per panicle without a negative effect on the number of panicles per plant or grain weight. NOG1 can significantly increase the grain yield of commercial high-yield varieties: introduction of NOG1 increases the grain yield by 25.8% in the NOG1-deficient rice cultivar Zhonghua 17, and overexpression of NOG1 can further increase the grain yield by 19.5% in the NOG1-containing variety Teqing. Interestingly, NOG1 plays a prominent role in increasing grain number, but does not change heading date or seed-setting rate. Our findings suggest that NOG1 could be used to increase rice production.
Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway
Authors: Benedetti Elisa , Pučić-Baković Maja , Keser Toma , Wahl Annika , Hassinen Antti , Yang Jeong-Yeh , Liu Lin , Trbojević-Akmačić Irena , Razdorov Genadij , Štambuk Jerko , Klarić Lucija , Ugrina Ivo , Selman Maurice H. J. , Wuhrer Manfred , Rudan Igor , Polasek Ozren , Hayward Caroline , Grallert Harald , Strauch Konstantin , Peters Annette , Meitinger Thomas , Gieger Christian , Vilaj Marija , Boons Geert-Jan , Moremen Kelley W. , Ovchinnikova Tatiana , Bovin Nicolai , Kellokumpu Sakari , Theis Fabian J. , Lauc Gordan , Krumsiek Jan 
Published: November 2017

AbstractImmunoglobulin G (IgG) is a major effector molecule of the human immune response, and aberrations in IgG glycosylation are linked to various diseases. However, the molecular mechanisms underlying protein glycosylation are still poorly understood. We present a data-driven approach to infer reactions in the IgG glycosylation pathway using large-scale mass-spectrometry measurements. Gaussian graphical models are used to construct association networks from four cohorts. We find that glycan pairs with high partial correlations represent enzymatic reactions in the known glycosylation pathway, and then predict new biochemical reactions using a rule-based approach. Validation is performed using data from a GWAS and results from three in vitro experiments. We show that one predicted reaction is enzymatically feasible and that one rejected reaction does not occur in vitro. Moreover, in contrast to previous knowledge, enzymes involved in our predictions colocalize in the Golgi of two cell lines, further confirming the in silico predictions.
Characterization of macrophages from schizophrenia patients
Authors: Ormel Paul R. , van Mierlo Hans C. , Litjens Manja , Strien Miriam E. van , Hol Elly M. , Kahn René S. , de Witte Lot D. 
Published: November 2017

AbstractGenetic, epidemiological and post mortem studies have described an association between schizophrenia (SCZ) and the immune system. Microglia, the tissue-resident macrophages of the brain, not only play an essential role in inflammatory processes, but also in neurodevelopment and synapse refinement. It has therefore been hypothesized that aberrant functioning of these myeloid immune cells is involved in SCZ pathogenesis. Until now cellular research into the role of myeloid cells in SCZ has been limited to monocytes and functional assays are lacking. In this study we used monocyte-derived macrophages (mo-MΦs) as a model for macrophages and microglia in the CNS and examined two main functions: Inflammatory responses and expression and regulation of synapse refinement molecules. The expression of 24 genes involved in these key functions was assessed. Mo-MΦs were generated from 15 SCZ patients and 15 healthy controls. The cells were exposed to pro-inflammatory and anti-inflammatory stimuli (LPS, R848, IL-4 and dexamethasone), and the response was measured by qPCR and ELISA analyses. One of the genes of interest, P2RX7 that is associated with psychiatric diseases, was significantly reduced in expression after LPS stimulation in SCZ patients. None of the other assessed characteristics were different in this functional screen between mo-MΦs from SCZ patients compared to controls. Although these data suggest that overall the function of macrophages in SCZ is not impaired, further studies with larger groups that enable the possibility to study clinical subgroups and perform additional screenings to asses the full phenotype of the mo-MΦs are needed to strengthen this conclusion.
Evaluating the impact of domestication and captivity on the horse gut microbiome
Authors: Metcalf Jessica L. , Song Se Jin , Morton James T. , Weiss Sophie , Seguin-Orlando Andaine , Joly Frédéric , Feh Claudia , Taberlet Pierre , Coissac Eric , Amir Amnon , Willerslev Eske , Knight Rob , McKenzie Valerie , Orlando Ludovic 
Published: November 2017

AbstractThe mammal gut microbiome, which includes host microbes and their respective genes, is now recognized as an essential second genome that provides critical functions to the host. In humans, studies have revealed that lifestyle strongly influences the composition and diversity of the gastrointestinal microbiome. We hypothesized that these trends in humans may be paralleled in mammals subjected to anthropogenic forces such as domestication and captivity, in which diets and natural life histories are often greatly modified. We investigated fecal microbiomes of Przewalski’s horse (PH; Equus ferus przewalskii), the only horses alive today not successfully domesticated by humans, and herded, domestic horse (E. f. caballus) living in adjacent natural grasslands. We discovered PH fecal microbiomes hosted a distinct and more diverse community of bacteria compared to domestic horses, which is likely partly explained by different plant diets as revealed by trnL maker data. Within the PH population, four individuals were born in captivity in European zoos and hosted a strikingly low diversity of fecal microbiota compared to individuals born in natural reserves in France and Mongolia. These results suggest that anthropogenic forces can dramatically reshape equid gastrointestinal microbiomes, which has broader implications for the conservation management of endangered mammals.
Spiral Modes and the Observation of Quantized Conductance in the Surface Bands of Bismuth Nanowires
Authors: Huber Tito E. , Johnson Scott , Konopko Leonid , Nikolaeva Albina , Kobylianskaya Anna , Graf Michael J. 
Published: November 2017

AbstractWhen electrons are confined in two-dimensional materials, quantum-mechanical transport phenomena and high mobility can be observed. Few demonstrations of these behaviours in surface spin-orbit bands exist. Here, we report the observation of quantized conductance in the surface bands of 50-nm Bi nanowires. With increasing magnetic fields oriented along the wire axis, the wires exhibit a stepwise increase in conductance and oscillatory thermopower, possibly due to an increased number of high-mobility spiral surface modes based on spin-split bands. Surface high mobility is unexpected since bismuth is not a topological insulator and the surface is not suspended but in contact with the bulk. The oscillations enable us to probe the surface structure. We observe that mobility increases dramatically with magnetic fields because, owing to Lorentz forces, spiral modes orbit decreases in diameter pulling the charge carriers away from the surface. Our mobility estimates at high magnetic fields are comparable, within order of magnitude, to the mobility values reported for suspended graphene. Our findings represent a key step in understanding surface spin-orbit band electronic transport.
Plant-to-plant communication triggered by systemin primes anti-herbivore resistance in tomato
Authors: Coppola Mariangela , Cascone Pasquale , Madonna Valentina , Di Lelio Ilaria , Esposito Francesco , Avitabile Concetta , Romanelli Alessandra , Guerrieri Emilio , Vitiello Alessia , Pennacchio Francesco , Rao Rosa , Corrado Giandomenico 
Published: November 2017

AbstractPlants actively respond to herbivory by inducing various defense mechanisms in both damaged (locally) and non-damaged tissues (systemically). In addition, it is currently widely accepted that plant-to-plant communication allows specific neighbors to be warned of likely incoming stress (defense priming). Systemin is a plant peptide hormone promoting the systemic response to herbivory in tomato. This 18-aa peptide is also able to induce the release of bioactive Volatile Organic Compounds, thus also promoting the interaction between the tomato and the third trophic level (e.g. predators and parasitoids of insect pests). In this work, using a combination of gene expression (RNA-Seq and qRT-PCR), behavioral and chemical approaches, we demonstrate that systemin triggers metabolic changes of the plant that are capable of inducing a primed state in neighboring unchallenged plants. At the molecular level, the primed state is mainly associated with an elevated transcription of pattern -recognition receptors, signaling enzymes and transcription factors. Compared to naïve plants, systemin-primed plants were significantly more resistant to herbivorous pests, more attractive to parasitoids and showed an increased response to wounding. Small peptides are nowadays considered fundamental signaling molecules in many plant processes and this work extends the range of downstream effects of this class of molecules to intraspecific plant-to-plant communication.
The Antibacterial and Anti-inflammatory Activity of Chicken Cathelicidin-2 combined with Exogenous Surfactant for the Treatment of Cystic Fibrosis-Associated Pathogens
Authors: Banaschewski Brandon J. H. , Baer Brandon , Arsenault Christina , Jazey Teah , Veldhuizen Edwin J. A. , Delport Johan , Gooyers Tracey , Lewis James F. , Haagsman Henk P. , Veldhuizen Ruud A. W. , Yamashita Cory 
Published: November 2017

AbstractCystic fibrosis (CF) is characterized by recurrent airway infections with antibiotic-resistant bacteria and chronic inflammation. Chicken cathelicin-2 (CATH-2) has been shown to exhibit antimicrobial activity against antibiotic-resistant bacteria and to reduce inflammation. In addition, exogenous pulmonary surfactant has been suggested to enhance pulmonary drug delivery. It was hypothesized that CATH-2 when combined with an exogenous surfactant delivery vehicle, bovine lipid extract surfactant (BLES), would exhibit antimicrobial activity against CF-derived bacteria and downregulate inflammation. Twelve strains of CF-pathogens were exposed to BLES+CATH-2 in vitro and killing curves were obtained to determine bactericidal activity. Secondly, heat-killed bacteria were administered in vivo to elicit a pro-inflammatory response with either a co-administration or delayed administration of BLES+CATH-2 to assess the antimicrobial-independent, anti-inflammatory properties of BLES+CATH-2. CATH-2 alone exhibited potent antimicrobial activity against all clinical strains of antibiotic-resistant bacteria, while BLES+CATH-2 demonstrated a reduction, but significant antimicrobial activity against bacterial isolates. Furthermore, BLES+CATH-2 reduced inflammation in vivo when either co-administered with killed bacteria or after delayed administration. The use of a host-defense peptide combined with an exogenous surfactant compound, BLES+CATH-2, is shown to exhibit antimicrobial activity against antibiotic-resistant CF bacterial isolates and reduce inflammation.
Timescale Separation of Positive and Negative Signaling Creates History-Dependent Responses to IgE Receptor Stimulation
Authors: Harmon Brooke , Chylek Lily A. , Liu Yanli , Mitra Eshan D. , Mahajan Avanika , Saada Edwin A. , Schudel Benjamin R. , Holowka David A. , Baird Barbara A. , Wilson Bridget S. , Hlavacek William S. , Singh Anup K. 
Published: November 2017

AbstractThe high-affinity receptor for IgE expressed on the surface of mast cells and basophils interacts with antigens, via bound IgE antibody, and triggers secretion of inflammatory mediators that contribute to allergic reactions. To understand how past inputs (memory) influence future inflammatory responses in mast cells, a microfluidic device was used to precisely control exposure of cells to alternating stimulatory and non-stimulatory inputs. We determined that the response to subsequent stimulation depends on the interval of signaling quiescence. For shorter intervals of signaling quiescence, the second response is blunted relative to the first response, whereas longer intervals of quiescence induce an enhanced second response. Through an iterative process of computational modeling and experimental tests, we found that these memory-like phenomena arise from a confluence of rapid, short-lived positive signals driven by the protein tyrosine kinase Syk; slow, long-lived negative signals driven by the lipid phosphatase Ship1; and slower degradation of Ship1 co-factors. This work advances our understanding of mast cell signaling and represents a generalizable approach for investigating the dynamics of signaling systems.