bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution trajectories of snake genes and genomes revealed by comparative analyses of five-pacer viper
Authors: Yin Wei , Wang Zong-ji , Li Qi-ye , Lian Jin-ming , Zhou Yang , Lu Bing-zheng , Jin Li-jun , Qiu Peng-xin , Zhang Pei , Zhu Wen-bo , Wen Bo , Huang Yi-jun , Lin Zhi-long , Qiu Bi-tao , Su Xing-wen , Yang Huan-ming , Zhang Guo-jie , Yan Guang-mei , Zhou Qi 
Published: August 2016

AbstractSnake’s numerous fascinating features distinctive from other tetrapods necessitate a rich history of genome evolution that is still obscure. To address this, we report the first high-quality genome of a viper,Deinagkistrodon acutusand comparative analyses using other species from major snake and lizard lineages. We map the evolution trajectories of transposable elements (TEs), developmental genes and sex chromosomes onto the snake phylogeny. TEs exhibit dynamic lineage-specific expansion. And in the viper many TEs may have been rewired into the regulatory network of brain genes, as shown by their associated expression with nearby genes in the brain but not in other tissues. We detect signatures of adaptive evolution in olfactory, venom and thermal-sensing genes, and also functional degeneration of genes associated with vision and hearing. ManyHoxandTbxlimb-patterning genes show evidence of relaxed selective constraints, and such genes’ phylogenetic distribution supports fossil evidence for a successive loss of forelimbs then hindlimbs during the snake evolution. Finally, we infer that the Z and W sex chromosomes had undergone at least three recombination suppression events at the ancestor of advanced snakes, with the W chromosomes showing a gradient of degeneration from basal to advanced snakes. These results, together with all the genes identified as undergoing adaptive or degenerative evolution episodes at respective snake lineages forge a framework for our deep understanding into snakes’ molecular evolution history.
Genetic Diversity, Population Structure and Species Delimitation ofTrialeurodes vaporariorum(greenhouse whitefly)
Authors: Wainaina J. M. , De Barro P. , Kubatko L. , Kehoe M. A. , Harvey J. , Karanja D. , Boykin L. M. 
Published: August 2016

AbstractGenetic diversity withinTrialeurodes vaporariorum(Westwood, 1856) remains largely unexplored, particularly within regions of Sub-Saharan Africa. In this study,T. vaporariorumsamples were obtained from three locations in Kenya: Katumani, Kiambu and Kajiado counties. DNA extraction, PCR and Sanger sequencing were carried out on ~750 bp fragment of the mitochondria cytochrome c oxidase I (COI) gene from individual whiteflies. In addition, global populations were assessed and 19 haplotypes were identified, with three main haplotypes (Hp_19, Hp_10, Hp_011) circulating within Kenya. Measures of genetic diversity amongT. vaporariorumpopulations resulted in haplotype diversity of 0.411, nucleotide diversity 0.00096, and Tajima’s D -0. 30315, (P>0.10). Analysis of population structure across global sequences using Structurama indicated one population globally, with posterior probability of 0.72. Bayesian and maximum likelihood phylogenetic analysis gave support for two clades (Clade I = an admixed global population and Clade II = subset of Kenyan and 1 Greek sequence). Species delimitation between the two clades was assessed by four parameters; posterior probability, Kimura’s two parameter (K2P), Rodrigo’s P (Randomly distinct) and Rosenberg’s reciprocal monophyly (P(AB). The two clades within the phylogenetic tree showed evidence of distinctness based on; Kimura two parameters (K2P) (p = -1.21E-01), Rodrigo’s P (RD) (p =0.05) and Rosenberg’s P(AB) (p = 2.3E -13). Overall, low genetic diversity within the Kenyan samples is a likely indicator of recent population expansion and colonization with this region and plausible signs of species complex formation in Sub-Saharan Africa.
Accelerated cell divisions drive the outgrowth of the regenerating spinal cord in axolotls
Authors: Rost Fabian , Albors Aida Rodrigo , Mazurov Vladimir , Brusch Lutz , Deutsch Andreas , Tanaka Elly M. , Chara Osvaldo 
Published: August 2016

AbstractAxolotls are unique in their ability to regenerate the spinal cord. However, the mechanisms that underlie this phenomenon remain poorly understood. Previously, we showed that resting stem cells in the axolotl spinal cord revert to a molecular state resembling embryonic neuroepithelial cells and functionally acquire rapid proliferative divisions during regeneration. Here we refine in space and time this increase in cell proliferation during regeneration, and identify a dynamic high-proliferation zone in the regenerating spinal cord. By tracking sparsely-labeled cells, we quantify cell influx into the regenerate. Taking a mathematical modelling approach, we integrate these quantitative biological datasets across cellular and tissue level to provide a mechanistic and quantitative understanding of regenerative spinal cord outgrowth. We find that the acceleration of the cell cycle is necessary and sufficient to drive the outgrowth of the regenerating spinal cord in axolotls.
BayesFM: a software program to fine-map multiple causative variants in GWAS identified risk loci
Authors: Fang Ming , Georges Michel 
Published: August 2016

AbsractWe herein describe a new method to fine-map GWAS-identified risk loci based on the Bayesian Least Absolute Shrinkage Selection Operator (LASSO) combined with a Monte Carlo Markov Chain (MCMC) approach, and corresponding software package (BayesFM). We characterize the performances of BayesFM using simulated data, showing that it outperforms standard forward selection both in terms of sensitivity and specificity. We apply the method to theNOD2locus, a well-established risk locus for Crohn’s disease, in which we identify 13 putative independent signals.
An RNA-binding tropomyosin recruits kinesin-1 dynamically tooskarmRNPs
Authors: Gáspár Imre , Sysoev Vasily , Komissarov Artem , Ephrussi Anne 
Published: August 2016

AbstractLocalization and local translation ofoskarmRNA at the posterior pole of theDrosophilaoocyte directs abdominal patterning and germline formation in the embryo. The process requires recruitment and precise regulation of motor proteins to form transport-competent mRNPs. We show that the posterior-targeting kinesin-1 is loaded upon nuclear export ofoskarmRNPs, prior to their dynein-dependent transport from the nurse cells into the oocyte. We demonstrate that kinesin-1 recruitment requires theDmTropomyosin1-I/C isoform, an atypical RNA-binding tropomyosin that binds directly to dimerizingoskar3’UTRs. Finally, we show that a small but dynamically changing subset ofoskarmRNPs gets loaded with inactive kinesin-1 and that the motor is activated during mid-oogenesis by the functionalized splicedoskarRNA localization element. This inefficient, dynamic recruitment of Khc decoupled from cargo-dependent motor activation constitutes an optmized, coordinated mechanism of mRNP transport, by minimizing interference with other cargo-transport processes and between the cargo associated dynein and kinesin-1.
Strong structuration theory and accounting information: an empirical study
Authors: Feeney Orla , Pierce Bernard 
Published: August 2016

PurposeThe purpose of this paper is to explore the role of accounting information in new product development (NPD) using Strong Structuration Theory. NPD is a complex social action involving a wide range of different actors and clusters of actors. Strong Structuration Theory allows the authors to take a broad view of this social system in order to develop a complete picture of the clusters of actors involved, to comprehensively examine the relevant structures, both internal and external, and to understand how these are formed, reformed or modified through the actions of agents.Design/methodology/approachA field study of the manufacturing division of a large group was conducted which explored how managers use accounting information during NPD. Examining how these managers draw upon their conjuncturally specific structures of signification, legitimation and domination, and how these are affected by their external structural conditions and their general dispositional frames of meaning, allowed the authors to develop an in-depth understanding of the managers’ behaviour during NPD.FindingsThese findings suggest that the managers’ use of accounting information is determined as much by the subjective nature of the managers themselves as it is by the objective characteristics of the structures with which they interact. By using Stones’ composite research strategy, which encourages the authors to conceive of internal structures as always looking outwards and external structures as always looking inwards, the findings help the authors to understand the “connecting tissue” between the different elements of the quadripartite of structuration which has been lacking in previous research in the area. This understanding of the connecting tissue between structures was facilitated by the micro-analysis of six managers within a given conjuncture. Using the concept of the agent-in-focus as a tool with which to switch lenses from manager to manager acknowledged the web-like interdependencies between different processes of structuration. This allowed an exploration of the relationships between the various agents and structures.Originality/valueThis study contributes to the understanding of Stones’ Strong Structuration Theory at both an ontological and methodological level by operationalising Stones’ model in a case study setting.
Antecedents and consequences of trust: an e-tail branding perspective
Authors: Das Gopal 
Published: August 2016

Purpose
– The purpose of this paper is to examine the antecedents and consequences of trust in online shopping from an e-tail branding perspective.

Design/methodology/approach
– A structured questionnaire was used to collect data online from Indian e-tail shoppers (n=309). A structural equation modelling (CB-SEM approach) was used to analyse the data.

Findings
– The results found e-tailer awareness, e-tailer associations, and e-tailer perceived quality as antecedents of trust in online shopping. The results also showed online trust positively influences the behavioural intentions, namely, purchase intention, repurchase, and recommendation.

Originality/value
– This study examines the applicability and branding and brand management principles in an e-tail branding context. Theoretical and managerial implications of these results are further discussed.
Estimation of non-catastrophic weather impacts for retail industry
Authors: Arunraj Nari Sivanandam , Ahrens Diane 
Published: August 2016

Purpose
– Weather is often referred as an uncontrollable factor, which influences customer’s buying decisions and causes the demand to move in any direction. Such a risk usually leads to loss to industries. However, only few research studies about weather and retail shopping are available in literature. The purpose of this paper is to develop a model and to analyze the relationship between weather and retail shopping behavior (i.e. store traffic and sales).

Design/methodology/approach
– The data set for this research study is obtained from two food retail stores and a fashion retail store located in Lower Bavaria, Germany. All these three retail stores are in same geographical location. The weather data set was provided by a German weather service agency and is from a weather station nearer to the retail stores under study. The analysis for the study was drawn using multiple linear regression with autoregressive elements (MLR-AR). The estimated coefficients of weather variables using MLR-AR model represent corresponding weather impacts on the store traffic and the sales.

Findings
– The snowfall has a significant effect on the store traffic and the sales in both food and fashion retail stores. In food retail store, the risk due to snowfall varies depending on the location of stores. There are also significant lagging effects of snowfall in the fashion retail store. However, the rainfall has a significant effect only on the store traffic in the food retail stores. In addition to these effects, the sales in the fashion retail store are highly affected by the temperature deviation.

Research limitations/implications
– Limitations in availability of data for the weather variables and other demand influencing factors (e.g. promotion, tourism, online shopping, demography of customers, etc.) may reduce efficiency of the proposed MLR-AR model. In spite of these limitations, this study can be able to quantify the effects of weather variables on the store traffic and the sales.

Originality/value
– This study contributes to the field of retail distribution by providing significant evidence of relationship between weather and retail business. Unlike previous studies, the proposed model tries to consider autocorrelation property, main and interaction effects between weather variables, temperature deviation and lagging effects of snowfall on the store traffic or the sales. The estimated weather impacts from this model can act as a reliable tool for retailers to explain the importance of different non-catastrophic weather events.
Crisis management as a critical perspective
Authors: Fischbacher-Smith Denis , Fischbacher-Smith Moira 
Published: August 2016

Purpose
– The purpose of this paper is to draw the authors experience of teaching a crisis management module within a range of MBA programmes in the UK, EU and USA. A key characteristic of the module was its development as a means of critiquing conventional approaches to management education. The paper details that experience.

Design/methodology/approach
– It reviews the literature on management education that has been critical of prescriptive and “toolkit-based” approaches to MBA education.

Findings
– An approach to a crisis management course is shown to provide a means of challenging dominant theoretical and practical approaches to management.

Practical implications
– The paper identifies challenges and personal and academic benefits for educators and students when engaging with critical perspectives and critical pedagogies.

Originality/value
– Through introducing the notion of crisis management, the paper discusses the importance of challenging theory and practice and creating within students, an appetite to challenge the dominant paradigms of conventional teaching and business practice.
What happens if a business school disappears? The intellectual foundations of BSIS
Authors: Kalika Michel , Shenton Gordon , Dubois Pierre-Louis 
Published: August 2016

Purpose
– The FNEGE and then EFMD have been interested in defining a methodology that would make it possible to highlight the impact of a business school on its home territory. This has led to the development of the “Business School Impact System” (BSIS), which is introduced in this paper. The paper aims to discuss these issues.

Design/methodology/approach
– The paper is structured as follows. The authors first present the methodological issues of the work that led us to develop the “BSIS” (EFMD, 2014). In a second section, the authors present BSIS in more detail.

Findings
– Based on the exploratory interviews and the literature review, the authors could first identify three main categories of impact: the financial impact; the impact on the regional community; and the impact on attractiveness and image.

Originality/value
– The first benefit of BSIS is linked to the creation of an information system on impact. Second, the BSIS process increases the awareness inside the business school regarding the significance of this issue. Third, the authors observe that for numerous members of the business school the question of the impact of their activity gives them a better image of their job, of what they are doing and why they are doing it. Fourth, the BSIS report constitutes a powerful tool for communication with the stakeholders. The final benefit lies in the reviewers’ recommendations on how to improve the impact of the business school.
Competencies of women entrepreneurs utilizing information marketing businesses
Authors: Revell-Love Carrie , Revell-Love Tara 
Published: August 2016

Purpose
– The purpose of this paper is to report the entrepreneurial competencies of women entrepreneurs who used information marketing businesses for their business-related education.

Design/methodology/approach
– A questionnaire-based survey of female entrepreneurs who engaged with one information marketing business was conducted. This study utilized Mitchelmore and Rowley’s (2013) survey instrument, Female Entrepreneurial Competencies (FEC), to analyse the four main entrepreneurial competency clusters: personal and relationship, business and management, entrepreneurial, and human relations competencies. Numeric data were collected via survey from women who engaged with a single information marketing company through e-mail and social media. Using descriptive analysis, the participants’ responses were assessed for the purpose of analysing the self-perceptions of their entrepreneurial competency abilities.

Findings
– The research found women ranked their competencies in the following order, from highest to lowest: personal and relationship, entrepreneurial, business and management, and human relations. The majority of women who engaged in this research’s information marketing business were middle-aged or slightly younger (between ages 26 and 44), highly educated, and owned a relatively new business.

Originality/value
– This study is the first to offer analysis of the entrepreneurial competencies of women entrepreneurs who utilize information marketing businesses for their business-related education. By identifying the entrepreneurial competencies of this subset of women, information marketing businesses could better focus their educational tools to meet the women’s competency needs.
Driving technology innovation through social entrepreneurship at Prezi
Authors: Mulloth Bala , Kickul Jill R. , Gundry Lisa K 
Published: August 2016

Purpose– There has been a profound neglect in most of the literature dealing with social entrepreneurship on the relationship between social entrepreneurship and technological innovation. The purpose of this paper is to provide new insights into that relationship by using the case of Prezi, a Budapest, Hungary-based mission-driven software company.Design/methodology/approach– The research approach used for this paper is qualitative in nature and uses the case study methodology. Evidence was based on interpretative/qualitative interviews and direct observations.Findings– Using the example of Prezi, the authors show that social entrepreneurial activities and projects could act as an important innovation source for technology-based industries.Originality/value– The authors use the case of Prezi and describe several of Prezi’s socially driven projects and show how they influence those involved with the company to continuously innovate and solve problems that have positive impact in the community as well as their core product offering.
Firms’ experience of SME-friendly policy and their participation and success in public procurement
Authors: Flynn Anthony , Davis Paul 
Published: August 2016

Purpose
– The purpose of this paper is to test the relationship between firms’ experience of small- and medium-size enterprise (SME)-friendly policy and their participation and success in public procurement.

Design/methodology/approach
– Hypothesised relationships between SME-friendly policy and three outcome variables – frequency of tendering, success rate in public contract competitions, and commercial orientation towards the public sector – are tested using survey data from 2,755 SME respondents.

Findings
– SME-friendly policy is found to be significant in explaining success rates and commercial orientation towards the public sector marketplace. It is not significant in explaining frequency of tendering.

Research limitations/implications
– The context for the study is Ireland. However, given institutional similarities in national public procurement regimes, particularly among EU Member States, the findings have relevance beyond the Irish context. The research design is cross-sectional and so does not allow for any causal claims to be made.

Originality/value
– This study puts forward and tests an original model of SME-friendly procurement policy and its associated outcomes for firms. It develops a comprehensive 16-item instrument to measure SME-friendly procurement policy. It uses SMEs as research informants instead of public buyers.
Does university play significant role in shaping entrepreneurial intention? A cross-country comparative analysis
Authors: Trivedi Rohit 
Published: August 2016

Purpose
– The purpose of this paper is to foster entrepreneurship among students and incubate more start-ups for economic prosperity, universities around the globe are required to play key role in developing overall conducive eco-system for student fraternity. Some previous studies have analysed student entrepreneurship and impact of entrepreneurship courses. However, role of universities as provider and enabler of entrepreneurial environment and its impact on entrepreneurial intent among students has not been studied in a cross-cultural context. Considering this, present study seeks to examine role played by universities in fostering entrepreneurial intention among post-graduate students.

Design/methodology/approach
– Researcher has taken the framework suggested by Kraaijenbrink et al. (2010) to understand university environment and theory of planned behaviour (Ajzen, 1985) to measure entrepreneurial intention and its antecedents among final year post-graduate management students of India, Malaysia and Singapore. Total sample size is 1,097. Data are analysed with help of exploratory factor analysis, multivariate analysis of variance (MANOVA) and structural equation modelling (SEM).

Findings
– Two factors emerge out of analysis in relation to university environment and support: first, targeted cognitive and non-cognitive support and second, general educational support. With help of SEM, attempt is made to find relationship between these two factors and entrepreneurial intention. It is found that university environment and support has significantly positive relationship with perceived behavioural control. With help of MANOVA, it is found that there is statistically significant difference between perceived university environment and support factors among students of India, Singapore and Malaysia. With this, for both factors highest mean score is found among students of Malaysia, followed by students of Singapore and India.

Originality/value
– Study has closely examined role played by university environment and support to foster entrepreneurship among young students. Findings of the study can be used by post-graduate educational institutes to design pedagogy, create enabling entrepreneurship support system and work towards becoming an entrepreneurial university.