bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is side branch lesion length an independent predictor of acute side branch occlusion in provisional strategy? Analysis of 524 consecutive bifurcation lesions
Authors: Zhao Zhiyong , Zhang Dong , Xu Bo , Wang Hao , Gao Guofeng , Yin Dong , Zhu Chenggang , Feng Lei , Zhao Yanyan , Dou Kefei 
Published: January 2018

AbstractObjectivesTo detect the impact of side branch (SB) lesion length on acute SB occlusion after main vessel (MV) stenting.MethodsFive hundred sixteen consecutive patients with 524 bifurcation lesions undergoing one‐stent techniques were studied. Multivariate logistic regression analysis was performed to identify independent predictors of acute SB occlusion. The lesions were also further divided into two groups according to the median SB lesion length. The incidences of SB occlusion and lesion characteristics in the two subgroups were compared.ResultsThe SB lesion length was not significantly different between lesions with and without SB occlusion. In the SB occlusion group, the distance between the position of the minimal lumen diameter and SB ostium was significantly shorter than that in the non‐SB occlusion group (1.76 ± 1.04 mm vs. 2.72 ± 2.65 mm; P = 0.0003). Multivariate logistic regression analysis showed that high BA before stenting, plaque accumulation located on the same side as the SB, the Thrombolysis In Myocardial Infarction (TIMI) flow grade of the SB before stenting, and the DS of the SB before MV stenting were independently predictive of SB occlusion.ConclusionsSB lesion length cannot be regarded as an independent predictor of acute SB occlusion after MV stenting.
Supra‐annular valve strategy for an early degenerated transcatheter balloon‐expandable heart valve
Authors: Kamioka Norihiko , Caughron Hope , Corrigan Frank , Block Peter , Babaliaros Vasilis 
Published: January 2018

AbstractCurrently, there are no recommendations regarding the selection of valve type for a transcatheter heart valve (THV)‐in‐THV procedure. A supra‐annular valve design may be superior in that it results in a larger effective orifice area and may have a lower chance of valve thrombosis after THV‐in‐THV. In this report, we describe the use of a supra‐annular valve strategy for an early degenerated THV.
Poplar‐Catkin‐Derived N, P Co‐doped Carbon Microtubes as Efficient Oxygen Electrocatalysts for Zn‐Air Batteries
Authors: Li Huaiyu , Wan Wenjun , Liu Xijun , Liu Haoxuan , Shen Sibo , Iv Fang , Luo Jun 
Published: January 2018

AbstractIn this study, poplar‐catkin‐derived N, P co‐doped carbon microtube catalysts with highly active sites and a large accessible surface area exhibit desirable oxygen reduction reaction (ORR) activity in an alkaline solution and excellent applications in Zn‐air batteries (ZABs). In particular, the catalytic activity of the N, P co‐doped carbon microtubes toward the ORR is as good as that of benchmark Pt/C, albeit better in terms of tolerance and stability. Furthermore, a ZAB fabricated using the as‐developed catalyst exhibits a specific capacity of 649 mAh gZn−1 and a peak power density of 125 mW cm−2; these values are comparable to those of Pt/C catalysts (644 mAh gZn−1 and 130 mW cm−2, respectively), indicative of the promising applications for sustainable energy storage. In addition, an alkaline water‐splitting cell powered by this assembled ZAB can generate H2 gas in a stable manner under ambient conditions. The successful conversion of considerable catkin sources to high‐value carbon materials will provide insights into the future development of other high‐performance electrocatalysts from abundant “green” bio‐waste.
Switch‐ON Near IR Fluorescent Dye Upon Protonation: Helically Twisted Bis(Boron Difluoride) Complex of π‐Extended Corrorin
Authors: Hisamune Yutaka , Kim Taeyeon , Nishimura Keiichi , Ishida Masatoshi , Toganoh Motoki , Mori Shigeki , Kim Dongho , Furuta Hiroyuki 
Published: January 2018

AbstractA novel helically twisted π‐extended corrorin derivative having two boron dipyrrin (BODIPY) moieties at the periphery, a BODIPY DYEmer (6‐BF2) cross‐bridged with π‐conjugated dipyrrinylidene unit, was synthesized and characterized. The neutral 6‐BF2 is nonfluorescent due to the internal photoinduced charge transfer (CT) character in the excited state as inferred from the femtosecond transient absorption spectroscopy. However, upon protonation, the CT process is suppressed and the species H6‐BF2+ becomes near infrared (IR) emissive. With the aid of rigid helical conformations in 6‐BF2, the helical isomers (P‐ and M‐forms) were resolved and their chiroptical property was investigated. The distinct circular dichroism (CD) spectral changes of the enantiomers were observed in the presence of acids, which demonstrates that 6‐BF2 can be utilized for potential acid‐responsive chiroptical materials.
An improved economic‐based nonlinear model predictive control strategy for the crude oil distillation process
Authors: Jin Qibin , Feng Zhenxiang , Liu Qie , Du Xinghan , Zhang Yuming , Cai Wu 
Published: January 2018

AbstractImproving performance and increasing process profitability represent a priority for the long‐term operation of the crude oil distillation process. To increase process profitability and maintain control performance, in this paper, an improved economic‐based nonlinear model predictive control (NMPC) strategy is used to optimize the crude oil distillation (CDU) process. Considering the strong coupling and nonlinear dynamics of the CDU process, we make some modifications for the existing NMPC strategy. To reduce the complexity of the nonlinear prediction model, a support vector regression (SVR) based model is employed to describe the dynamical behaviour of the CDU process. Considering the coupling of the CDU process, we propose the concept of the coupling weighting factor to modify the objective function of the NMPC optimization problem. The simulation results demonstrate the effectiveness of the proposed improved NMPC algorithm for the CDU process.
New dimensions of asymmetric division in vertebrates
Authors: Vertii Anastassiia , Kaufman Paul D. , Hehnly Heidi , Doxsey Stephen 
Published: January 2018

AbstractTraditionally, we imagine that cell division gives rise to two identical daughter cells. Nevertheless, all cell divisions, to some degree, display asymmetry. Asymmetric cell division is defined as the generation of two daughter cells with different physical content and/or developmental potential. Several organelles and cellular components including the centrosome, non‐coding RNA, chromatin, and recycling endosomes are involved in the process of asymmetric cell division. Disruption of this important process is known to induce profound defects in development, the immune response, regeneration of tissues, aging, and cancer. Here, we discuss recent advances that expand our understanding of the mechanisms and consequences of asymmetric cell division in vertebrate organisms.
Boundary Layers in Periodic Homogenization of Neumann Problems
Authors: Shen Zhongwei , Zhuge Jinping 
Published: January 2018

AbstractThis paper is concerned with a family of second‐order elliptic systems in divergence form with rapidly oscillating periodic coefficients. We initiate the study of homogenization and boundary layers for Neumann problems with first‐order oscillating boundary data. We identify the homogenized system and establish the sharp rate of convergence in L2 in dimension three or higher. Regularity estimates are also obtained for the homogenized boundary data in both Dirichlet and Neumann problems. The results are used to establish a higher‐order convergence rate for Neumann problems with nonoscillating data. © 2018 Wiley Periodicals, Inc.
Electronic Rearrangement in Molecular Plasmons: An Electron Density and Electrostatic Potential‐Based Study
Authors: Paul Mishu , Balanarayan P. 
Published: January 2018

AbstractPlasmonic modes in single‐molecule systems have been previously identified by scaling two‐electron interactions in calculating excitation energies. Analysis of transition dipole moments for states of polyacenes based on configuration interaction is another method for characterising molecular plasmons. The principal features in the electronic absorption spectra of polyacenes are a low‐intensity, lower‐in‐energy peak and a high‐intensity, higher‐in‐energy peak. From calculations using time‐dependent density functional theory with the B3LYP/cc‐pVTZ basis set, both these peaks are found to result from the same set of electronic transitions, that is, HOMO−n to LUMO and HOMO to LUMO+n, where n varies as the number of fused rings increases. In this work, the excited states of polyacenes, naphthalene through pentacene, are analysed using electron densities and molecular electrostatic potential (MESP) topography. Compared to other excited states the bright and dark plasmonic states involve the least electron rearrangement. Quantitatively, the MESP topography indicates that the variance in MESP values and the displacement in MESP minima positions, calculated with respect to the ground state, are lowest for plasmonic states. The excited‐state electronic density profiles and electrostatic potential topographies suggest the least electron rearrangement for the plasmonic states. Conversely, high electron rearrangement characterises a single‐particle excitation. The molecular plasmon can be called an excited state most similar to the ground state in terms of one‐electron properties. This is found to be true for silver (Ag6) and sodium (Na8) linear chains as well.
Development of Electromagnetic Transient Simulation Models for Power Quality Analysis of Distribution Systems
Authors: NAGASHIMA TOMOHIRO , FUKUSHIMA KENTARO , NODA TAKU 
Published: January 2018

SUMMARYDue to the rapid spread of renewable energy power sources in recent years, voltage rise problems in distribution systems caused by reverse power flow from these renewable energy power sources especially from photovoltaic (PV) power generation systems are of great concern. To cope with this kind of problems, conventional voltage regulation devices such as load‐ratio transformers in the substation and step voltage regulators (SVRs) on the distribution line are basically used. If their voltage regulation capability is not sufficient, the power conditioning systems of PV power generation systems may be modified so as to supply reactive power and a static synchronous compensator (STATCOM) may be applied to the distribution system. Therefore, the coordination of these conventional and new voltage regulation devices is necessary for the design of smarter distribution systems, and electromagnetic transient (EMT) simulations of distribution systems with these devices have to be carried out to assess power quality. To this end, the authors have developed EMT simulation models of distribution substations, SVRs and distribution STATCOMs, and they are routinely used for power quality assessment studies. This paper presents these simulation models and a simulation example.
Terahertz Active Metamaterials Based on Stacked Closed‐Ring Resonator Arrays
Authors: MATSUI TATSUNOSUKE , ASANO SHUN , MORI HIROKI 
Published: January 2018

SUMMARYMetamaterials, which can show novel optical functionalities beyond conventional optics, have been actively studied in recent years. As one of approaches to add tunability on resonant characteristics of metamaterials, slightly shifting relative position of stacked metamaterials or metasurfaces has been reported. In this study, based on numerical simulation we have designed stacked closed‐ring resonator (CRR) arrays that show relatively large spectral shift with a small lateral shift of the stacked layers in terahertz (THz) range. We also show that changing dielectric constant of the dielectric media between CRR arrays is also effective to obtain large spectral shift of the resonant responses. Our findings may be utilized to develop novel type of THz active devices and also sensing devices.
Pain in severe dementia: A comparison of a fine‐grained assessment approach to an observational checklist designed for clinical settings
Authors: Hadjistavropoulos T. , Browne M.E. , Prkachin K.M. , Taati B. , Ashraf A. , Mihailidis A. 
Published: January 2018

AbstractBackgroundFine‐grained observational approaches to pain assessment (e.g. the Facial Action Coding System; FACS) are used to evaluate pain in individuals with and without dementia. These approaches are difficult to utilize in clinical settings as they require specialized training and equipment. Easy‐to‐use observational approaches (e.g. the Pain Assessment Checklist for Limited Ability to Communicate‐II; PACSLAC‐II) have been developed for clinical settings. Our goal was to compare a FACS‐based fine‐grained system to the PACSLAC‐II in differentiating painful from non‐painful states in older adults with and without dementia.MethodWe video‐recorded older long‐term care residents with dementia and older adult outpatients without dementia, during a quiet baseline condition and while they took part in a physiotherapy examination designed to identify painful areas. Videos were coded using pain‐related behaviours from the FACS and the PACSLAC‐II.ResultsBoth tools differentiated between painful and non‐painful states, but the PACSLAC‐II accounted for more variance than the FACS‐based approach. Participants with dementia scored higher on the PACSLAC‐II than participants without dementia.ConclusionThe results suggest that easy‐to‐use observational approaches for clinical settings are valid and that there may not be any clinically important advantages to using more resource‐intensive coding approaches based on FACS. We acknowledge, as a limitation of our study, that we used as baseline a quiet condition that did not involve significant patient movement. In contrast, our pain condition involved systematic patient movement. Future research should be aimed at replicating our results using a baseline condition that involves non‐painful movements.SignificanceExamining older adults with and without dementia, a brief observational clinical approach was found to be valid and accounted for more variance in differentiating pain‐related and non‐pain‐related states than did a detailed time‐consuming fine‐grained approach.
Enhancing Effect of Residual Lignins from D. Sinicus Pretreated with Fenton Chemistry on Enzymatic Digestibility of Cellulose
Authors: Wu Kai , Ying Wenjun , Shi Zhengjun , Yang Haiyan , Zheng ZhiFeng , Zhang JiaYan , Yang Jing 
Published: January 2018

AbstractTo screen and evaluate possible functional factors in the bamboo lignin moiety that could block non‐productive adsorption of enzyme proteins on lignin, milled wood lignin (MWL) and Fenton oxidized lignin (FOLs) were prepared and incorporated in the enzymatic hydrolysis of Avicel. The addition of MWL decreased the 72 h glucose yields of cellulose from 57.1 % to 45.3 %, while FOLs effectively improved the enzymatic digestibility up to 69.5 %, which was 22 % higher than the system without the use of FOLs. The adsorption affinity and binding strength of cellulase with FOLs were lower than that with MWL. After Fenton pretreatment, hydrophilicity of lignins increased due to formation of C−O− and O−C=O bonds. Furthermore, high surface negative charges on FOLs resulted in strong electrostatic repulsion against the negatively charged cellulases. Finally, analysis of FOLs with 13C and 2D‐HSQC NMR indicated that the cleavage of β‐O‐4 linkages and demethoxylation occurred, and that less condensed structures at the Cβ and Cγ positions were observed. These oxidation reactions of the bamboo lignin lead to the formation of functional factors to alleviate irreversible adsorption of cellulase onto FOLs, and thus were responsible for promoting enzymatic digestibility efficiency.
Neural correlates of lower limbs proprioception: An fMRI study of foot position matching
Authors: Iandolo Riccardo , Bellini Alessandro , Saiote Catarina , Marre Ilaria , Bommarito Giulia , Oesingmann Niels , Fleysher Lazar , Mancardi Giovanni Luigi , Casadio Maura , Inglese Matilde 
Published: January 2018

AbstractLittle is known about the neural correlates of lower limbs position sense, despite the impact that proprioceptive deficits have on everyday life activities, such as posture and gait control. We used fMRI to investigate in 30 healthy right‐handed and right‐footed subjects the regional distribution of brain activity during position matching tasks performed with the right dominant and the left nondominant foot. Along with the brain activation, we assessed the performance during both ipsilateral and contralateral matching tasks. Subjects had lower errors when matching was performed by the left nondominant foot. The fMRI analysis suggested that the significant regions responsible for position sense are in the right parietal and frontal cortex, providing a first characterization of the neural correlates of foot position matching.
Lymph node ratio as a prognostic factor in metastatic cutaneous head and neck squamous cell carcinoma
Authors: Vasan Kartik , Low Tsu‐Hui (Hubert) , Gupta Ruta , Ashford Bruce , Asher Rebecca , Gao Kan , Ch'ng Sydney , Palme Carsten E. , Clark Jonathan R. 
Published: January 2018

AbstractBackgroundThe prognostic impact of the size and number of nodal metastases in head and neck cutaneous squamous cell carcinoma (SCC) is well established. The purpose of this study was to validate the prognostic significance of the lymph node ratio in metastatic head and neck cutaneous SCC.MethodsA retrospective review of 326 patients with head and neck cutaneous SCC with parotid and/or cervical nodal metastases was performed. The primary endpoints were overall survival (OS) and disease‐free survival (DFS). The minimal‐P approach was used to investigate the optimal lymph node ratio threshold.ResultsOur data included 77 recurrences and 101 deaths. A lymph node ratio of 6% was a significant predictor of shorter DFS (hazard ratio [HR] 1.62; 95% confidence interval [CI] 1.11‐2.38; P = .01) and OS (HR 1.63; 95% CI 1.03‐2.58; P = 0.04) on multivariable analysis.ConclusionThe lymph node ratio is an independent prognosticator of survival outcomes in patients presenting with metastatic head and neck cutaneous SCC. A lymph node ratio >6% is a significant threshold to categorize patients into low and high risk.
Fabrication of functionalized citrus pectin/silk fibroin scaffolds for skin tissue engineering
Authors: Türkkan Sibel , Atila Deniz , Akdağ Akın , Tezcaner Ayşen 
Published: January 2018

AbstractIn this study, novel porous three‐dimensional (3D) scaffolds from silk fibroin (SF) and functionalized (amidated and oxidized) citrus pectin (PEC) were developed for skin tissue engineering applications. Crosslinking was achieved by Schiff's reaction in borax presence as crosslinking coordinating agent and CaCl2 addition. After freeze‐drying and methanol treatment, plasma treatment (10 W, 3 min) was applied to remove surface skin layer formed on scaffolds. 3D matrices had high porosity (83%) and interconnectivity with pore size about 120 µm that providing suitable microenvironment for cells. Modifications on PEC chain and crosslinking of scaffolds were verified by fourier‐transform infrared spectroscopy (FTIR) analysis and spectrophotometric assay. Scaffolds showed low weight loss (21.3% in 40 days) and high water uptake ability in phosphate‐buffered saline (800% in 24 h). Mechanical properties of 3D matrices satisfied the stability of scaffolds under compressive stress and supported adhesion, proliferation and penetration of fibroblast cells. Our results suggested that modified PEC‐SF scaffolds would be proposed for use in tissue engineered skin dermal substitutes. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2625–2635, 2018.
Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1‐mediated deacetylation of FXR and PGC‐1α
Authors: Zhu Lili , Wang Lei , Cao Fei , Liu Peng , Bao Haidong , Yan Yumei , Dong Xin , Wang Dong , Wang Zhongyu , Gong Peng 
Published: January 2018

AbstractBackgroundThe purpose of the present study was to investigate the effect and potential mechanism of chlorogenic acid (CA) on liver injury induced by cholestasis in a rat model of bile duct ligation (BDL).MethodsRats received vehicle or CA (20, 50, or 100 mg/kg per day) orally for 3 days. On the 4th day, the rats underwent sham or BDL surgery, and were orally administrated vehicle or CA for 3 or 7 days. mRNA and protein expression levels were evaluated by qRT‐PCR and western blot.ResultsAfter BDL, plasma levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), and total bile acids (TBA) were increased and typical pathological changes were observed in liver morphology. Hepatic uptake transporters (Ntcp, Oatp 1a4, and Oatp 1b2) were downregulated, while efflux transporters (Bsep and Mrp 2/3/4) were upregulated. BDL inhibited the expressions of Cyp7a1, Cyp8b1, and Cyp27a1 and induced Ugt1a1. CA treatment decreased ALT, AST, TBIL, and TBA (P < 0.05) and alleviated the liver pathological changes. The degree of expression changes in the transporters and enzymes was extended by CA (P < 0.05). SIRT1 protein was induced after CA treatment in BDL rats.ConclusionsChlorogenic acid attenuated hepatotoxicity and cholestasis by decreasing the uptake and synthesis of bilirubin and bile acids and accelerating the metabolism and efflux of bilirubin and bile acids.
Impact of column and stationary phase properties on the productivity in chiral preparative LC
Authors: Forssén Patrik , Fornstedt Torgny 
Published: January 2018

AbstractBy generating 1500 random chiral separation systems, assuming two‐site Langmuir interactions, we investigated numerically how the maximal productivity (PR,max) was affected by changes in stationary phase adsorption properties. The relative change inPR,max, when one adsorption property changed 10%, was determined for each system and for each studied parameter the corresponding productivity change distribution of the systems was analyzed. We could conclude that there is no reason to have columns with more than 500 theoretical plates and larger selectivity than 3. More specifically, we found that changes in selectivity have a major impact onPR,maxif it is below ∼2 and, interestingly, increasing selectivity when it is above ∼3 decreasesPR,max. Increase in relative saturation capacity will have a major impact onPR,maxif it is below ∼40%, but only modest above this percent. Increasing total monolayer saturation capacity, or decreasing the first eluting enantiomer's retention factor, will have a modest effect onPR,maxand increased efficiency will have almost no effect at all onPR,maxunless it is below ∼500 theoretical plates. Finally, we showed that chiral columns with superior analytic performance might have inferior preparative performance, or vice versa. It is, therefore, not possible to assess columns based on their analytical performance alone.
Orientation preserving mesh optimisation and preconditioning
Authors: Paul Jordi 
Published: January 2018

SummaryA robust mesh optimisation method is presented that directly enforces the resulting deformation to be orientation preserving. Motivated by aspects from mathematical elasticity, the energy functional of the mesh deformation can be related to a stored‐energy functional of a hyperelastic material. Formulating the functional in the principal invariants of the deformation gradient allows fine‐grained control over the resulting deformation. Solution techniques for the arising nonconvex and highly nonlinear system are presented. As existing preconditioners are not sufficient, a partial differential equation–based preconditioner is developed.