bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of a Healing, Antimicrobial, and Anti‐Inflammatory Gel Containing Cellulose and Curcumin for Wound Treatment
Authors: Neves Danielle Dias , da Silva Wagner Eduardo , de Castro Souza Neto Júnior José , da Silva Junior Valdemiro Amaro , Belian Mônica Freire 
Published: September 2024

AbstractThis work presents the production of a gel containing bacterial cellulose and curcumin and the anti‐inflammatory and healing activity assayed according to an animal model (BC‐curcumin). The methodology consisted of the production of bacterial cellulose (BC) using a glycerol‐based culture medium, subsequentially purified and transformed into a powder and added to an ethanolic curcumin solution, acting as a carrier matrix of a bioactive compound, as well as this component present in the gel proposal, promotes the prolonged liberation of curcumin. The BC and BC‐curcumin were characterized by infrared spectroscopy, thermogravimetric analysis, and scanning electron microscopy. The antimicrobial activity of the developed gel was confirmed through halo inhibition zone assay and minimum inhibitory concentration against strains of Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli, whose presenting halos with diameters of 21, 26, and 14 mm, and concentrations of 63.78, 6.16 and 136.65 μg mL−1 for the three microorganisms, respectively. The healing and anti‐inflammatory activities were observed according to in vivo assays using Wistar rats, which demonstrated a high healing potential, also confirmed by histopathological study of the tissue samples extracted from the healing area.
Synthesis of Novel Benzimidazole Analogs for Neurodegenerative Diseases by Targeting Prolyl Oligopeptidase
Authors: Shakoor Abdul , Alam Aftab , Ali Mumtaz , Ullah Saeed , Halim Sobia Ahsan , Rehman Munir Ur , AlAsmari Abdullah F. , Alasmari Fawaz , Khan Ajmal , Khan Momin , Al‐Harrasi Ahmed 
Published: September 2024

AbstractA novel series of benzimidazole hydrazone‐Schiff bases have been prepared through multi‐step reaction process and structurally confirmed by13C‐,1H‐NMR and HR‐MS (ESI) spectroscopic techniques and evaluated against prolyl oligopeptidase (POP) inhibitory activity. In the series, eleven derivatives 20, 14 15, 19, 10, 9, 11, 4, 5, 18, and 21 revealed excellent inhibition potential having IC50 values from (IC50=1.44±0.08 μM) to (IC50=5.66±0.48 μM). However, six out of twenty compounds 12, 16, 13, 17, 22, and 3 attributed significant activity while, three compounds were found good active in the range of IC50 values 10.43±0.57 to 11.45±0.63 μM. The docking studies indicates that the hydrazone moiety show an imperative part in binding with one of the catalytic residues (Arg643) in the substrate binding region of POP enzyme. The excellent inhibitions of these compounds for POP enzyme may lead them to be a good candidates for drug against neurodegenerative diseases.
Green Silver Nanoparticles and Their Activity as Antifungal Agents Against Penicillium digitatum Causing Green Mould of Citrus
Authors: Sharma Kishor , Raj Harender , Sharma Adikshita , Sharma Monica , Sharma Amit , Thakur Atul 
Published: September 2024

AbstractThe green synthesis of silver nanoparticles (SNPs) using aqueous extracts of five plants viz., Ocimum americanum, Azadirachta indica, Allium sativum, Eucalyptus hybrida, Zingiber officinale were evaluated for their antifungal property against Penicillium digitatum, a green mould pathogen of citrus fruits. The five plant species were selected from a screening of aqueous extracts from 16 plant species. The efficacy of aqueous extracts, at 50 % concentration, ranged from 14.44–68.52 % inhibition in mycelia growth of P. digitatum. Among SNPs, O. americanum was found most efficacious, at 1000 ppm concentration, with 80.7 % mycelial inhibition followed by A. indica with 77.4 % mycelial growth inhibition of fungal pathogen. Further, physical and structural characterization of SNPs of O. americanum and A. indica was carried out. The characterization analysis executed via transmission and scanning electron microscope revealed size distribution and nanoparticles were spherical to irregularly shaped ranging from 22.8–250 nm in O. americanum and 26.5–500 nm in A. indica. In UV‐visible spectrophotometer, the absolute absorption peak was recorded at 448 nm and 442 nm for O. americanum and A. indica, respectively. FTIR analysis of SNPs of A. indica and O. americanum confirmed the presence of carboxyl, amide group and secondary amines which were the main constituent of proteins. The novelty of the present study is in the green synthesis of silver nanoparticles with potential in the management of postharvest pathogens of fruit crops. The synthesis of SNPs used in this study is simple, environmentally benign and cost‐effective using aqueous extract of native plants.
Synthesis, Cytotoxicity, and Quantitative Structure–Activity Relationship Studies of Alkyl Triphenylphosphonium Pinostrobin Derivatives
Authors: Tran Tu Hoai , Le Tho Huu , Truong Hai Nhung , Dang Thanh Minh , Nguyen Mai Thanh Thi , Nguyen Nhan Trung , Dang Phu Hoang 
Published: September 2024

AbstractPinostrobin, an isolated compound from Boesenbergia rotunda, has been shown to have potent anti‐proliferation and apoptosis effects in cancer stem‐like cells. However, its hydrophobic properties reduce its bioavailability. Eight new alkyl‐TPP+ pinostrobin derivatives were synthesized and assessed for their cytotoxicity against the human HepG2 liver cancer cell line using the alamarBlue assay. All derivatives exhibited moderate cytotoxicity, with the IC50 values ranging from 38.55–101.95 μM, and were more potent than pinostrobin and pinostrobin hydrazone (IC50>100 μM). Four alkyl‐TPP+ pinostrobin hydrazone amide derivatives showed more potent cytotoxicity than four alkyl‐TPP+ pinostrobin ester derivatives. QSAR analysis showed key 3D structural descriptors of TPP+‐based compounds responsible for cytotoxicity against HepG2 cells for the first time. The resultant 3D‐QSAR models using PLS and PCR methods were evaluated and found reliable in predicting the cytotoxicity of other TPP+‐based compounds.
Synthesis, Characterization, and Optical Properties of Novel Heterocyclic Azo Dyes and Evaluation of Their Antioxidant Activity as an Active Sunscreen Agent
Authors: Surendranaik Y. , Venkatesh Talavara , Ereshanaik  , Chethan  
Published: September 2024

AbstractWe synthesized some novel isoxazole azo derivatives using conventional methods and studied their linear, non‐linear optical properties and antioxidant activity. UV‐Vis spectroscopy revealed absorption bands ranging from 310–470 nm for the obtained compounds. Compounds 3 c and 3 b, for example, showed a large redshift and solvatochromic behavior. NLO analysis results show that compounds exhibit a greater NLO response than the magnitude of urea done by the DFT method. The electrochemical properties of compounds are studied using cyclic voltammetry and results are used for calculation of HOMO and LUMO experimentally. The antioxidant activity of the synthesized azo dyes displayed that 3 c has excellent antioxidant activity with the highest percentage (71.54605 %) of radical inhibition as compared to reference standard Vit‐C. Molecular docking analysis shows that compounds have a strong binding affinity in the range of −7.0 to −4.6 kcal/mol compared to Vit‐C, which has a binding affinity of −3.6 kcal/mol. The sun protection factor performance was determined by UV‐Vis spectroscopy, and results show that compounds are most effective, exhibit a remarkable SPF value, and offer superior sun protection by absorbing UV rays.
An Ultramicroporous Zinc‐Based Zeolitic Imidazolate Framework‐8 for the Adsorption of CO2, CH4, CO, N2 and H2: A Combined Experimental and Theoretical Study
Authors: Ahmed Khalil Sana , Missaoui Nadhem , Alatawi Raedah A. S. , Keshk Ali A. , Alatawi Obaidallah , Albalawi Tahani A. , Gross Andrew J 
Published: September 2024

AbstractAn alternative synthesis route to obtain ultramicroporous zeolitic imidazolate framework‐8 (ZIF‐8) is reported that is rapid and does not require organic solvent or heating. The polyethylene glycol‐templated ZIF‐8 nanoparticles (<50 nm size) exhibited a high BET (Brunauer, Emmett and Teller) surface area of 1853 m2/g, a total pore volume of 0.73 cm3/g, and 0.54 nm ultramicropores. A new approach is introduced here to better understand gas adsorption in porous metal organic frameworks (MOFs) that combines theoretical and experimental isotherm data obtained for five gases with statistical physics modelling. The multiscale analytical model reveals that the gas molecules, irrespective of their structure, adsorb in a mixed orientation at low temperature, and a parallel multi‐molecular orientation at higher temperature. The number of gas molecules adsorbed per site ranged from 0.83–2.2 while the number of adsorbent layers ranged between 1.4–5.6, depending on the gas and the temperature. The multilayer adsorption processes involved adsorption energies from 2.85 kJ/mol–9.77 kJ/mol for all gases, consistent with physisorption via van der Waals and London dispersion forces. The initial adsorption energies were higher and therefore stronger. A particularly high capacity for CO2 of 1088 mg(CO2)/g at 298 K was observed while H2 adsorption was only 9 mg(H2)/g. The other gases adsorbed at 145 mg/g–245 mg/g at 298 K. Thermodynamic functions that governed the adsorption process such as the internal energy, the enthalpy, and Gibbs free energy, are also reported, as well as the adsorption entropies, for the 5 gases.
Production Sericin/Poly(Vinyl Alcohol) Blend Membranes Containing One‐Step Synthesized Silver Nanoparticles by UV Radiation for Obtaining Versatile Antibacterial Materials
Authors: Temel Aleyna , Nuran Doğan Hatice , Yıldız Emine , Yanık Gizem , Gün Gök Zehra 
Published: September 2024

AbstractIn this study, silver nanoparticles (AgNPs) were in‐situ synthesized in silk sericin/poly(vinyl alcohol) (SS/PVA) mixtures by an easy one‐step synthesis method with the presence of ultraviolet (UV) radiation. Then, the SS/PVA composite membranes containing AgNPs were obtained by solvent casting method. The chemical structures of the membranes were investigated by fourier‐transform infrared spectroscopy (FTIR) and results showed that the membranes were a mixture of silk sericin and PVA. The morphological features of the membranes were investigated by field emission scanning electron microscopy (FE‐SEM) and it was seen that AgNPs containing membranes have heterogeneous structures. Energy dispersive spectroscopy (EDS) analysis revealed that the membranes contain carbon, oxygen, nitrogen, sulfur and silver. X‐ray diffractometer (XRD) and thermogravimetric (TGA) analyses also proved the presence of AgNPs in the structure of membranes. The antibacterial activities of membranes containing AgNPs were investigated on Staphylococcus aureus and Escherichia coli bacteria with disk diffusion test and liquid culture medium incubation. It was found that SS/PVA membranes containing 5 and 10 mM AgNPs have quite high antibacterial activity on both types of bacteria. The functional SS/PVA membranes have capacity to be used in biomedical applications such as wound care materials.
Synthesis of Accessible Triphenylamine End‐Capped Oligothiophene Emitters for Solution Processed and Printed OLEDs
Authors: Ghanem Tatiana , Gasonoo Akpeko , Yassin Ali , Puchán Sánchez Darío , Blanchard Philippe , Welch Gregory C. , Cabanetos Clément 
Published: September 2024

AbstractDisplays have become ubiquitous in our modern and highly interconnected lives. Complex vacuum processed multi‐stacks are widely integrated into high tech, high value products such as smart phones, while solution processed large area single‐layer OLEDs appear more adequate for basic applications focusing on recyclability such as packaging, road signage, advertising, and single‐use health care products. In this context, we report herein the design, synthesis, and characterization of an accessible series of oligothiophenes end‐capped triphenylamines that were preprepared by atom‐economical direct (hetero)arylation reactions and successfully used as emitter in solution processed devices, from lab scale to large area printed and flexible demonstrator.
Giant Optical Anisotropy Induced by Magnetic Order in FePS3/WSe2 Heterostructures
Authors: Chen Junying , Xie Xing , Oyang Xinyu , Li Shaofei , He Jun , Liu Zongwen , Wang Jian‐Tao , Liu Yanping 
Published: September 2024

AbstractMagnetic 2D materials offer a promising platform for manipulating quantum states at the nanoscale. Recent studies have underscored the significant influence of 2D magnetic materials on the optical behaviors of transition‐metal dichalcogenides (TMDs), revealing phenomena such as interlayer exciton‐magnon interactions, magnetization‐dependent valley polarization, and an enhanced Zeeman effect. However, the controlled manipulation of anisotropic optical properties in TMDs via magnetism remains challenging. Here, the magnetic ordering in FePS3 profoundly impacts the optical characteristics of WSe2, achieving a giant linear polarization degree of 5.1 in exciton emission is demonstrated. This is supported by a detailed analysis of low‐temperature photoluminescence (PL) and Raman spectra from nL‐FePS3/WSe2 heterostructures. These findings indicate that a phase transition in FePS3 from paramagnetic to antiferromagnetic enhances interlayer Coulomb interactions, inducing a transition from non‐polar to polar behavior in the heterostructures. Additionally, valley‐polarized PL spectra under magnetic fields from −9 to 9 T reveal the influence of FePS3 on valley polarization and Zeeman splitting of excitons in monolayer WSe2. These results present a novel strategy for tailoring the optoelectronic properties of 2D magnetic van der Waals heterostructures, paving the way for advancements in nanoscale device design.
Gene‐Engineered Cerium‐Exosomes Mediate Atherosclerosis Therapy Through Remodeling of the Inflammatory Microenvironment and DNA Damage Repair
Authors: Wei Peng , Wang Yifan , Feng Haiyan , Zhang Fan , Ji Zhenyan , Zhang Kai , Zhang Qiang , Jiang Lixian , Qian Yuxuan , Fu Yimu 
Published: September 2024

AbstractThe pro‐inflammatory immune microenvironment in the localized lesion areas and the absence of DNA damage repair mechanisms in endothelial cells serve as essential accelerating factors in the development of atherosclerosis. The lack of targeted therapeutic strategies represents a significant limitation in the efficacy of therapeutic agents for atherosclerosis. In this study, Genetically engineered SNHG12‐loaded cerium‐macrophage exosomes (Ce‐Exo) are designed as atherosclerosis‐targeting agents. In vivo studies demonstrated that Ce‐Exo exhibited multivalent targeting properties for macrophages, with a 4.1‐fold higher atherosclerotic plaque‐aggregation ability than that of the control drugs. This suggests that Ce‐Exo has a higher homing capacity and deeper penetration into the atherosclerotic plaque. In apolipoprotein E‐deficient mice, Ce‐Exo found to effectively remodel the immune microenvironment in the lesion area, repair endothelial cell damage, and inhibit the development of atherosclerosis. This study provides a novel approach to the treatment of atherosclerosis and demonstrates the potential of cell‐derived drug carriers in biomedicine.
Covalent Triazine‐Based Frameworks with Ru‐tda Based Catalyst Anchored via Coordination Bond for Photoinduced Water Oxidation
Authors: Salati Martina , Dorchies Florian , Wang Jia‐Wei , Ventosa Marta , González‐Carrero Soranyel , Bozal‐Ginesta Carlota , Holub Jan , Rüdiger Olaf , DeBeer Serena , Gimbert‐Suriñach Carolina , Durrant James R. , Ertem Mehmed Z. , Gil‐Sepulcre Marcos , Llobet Antoni 
Published: September 2024

AbstractLight‐induced water splitting (hν‐WS) for the production of hydrogen as a solar fuel is considered a promising sustainable strategy for the replacement of fossil fuels. An efficient system for hν‐WS involves a photoactive material that, upon shining light, is capable of separating and transferring charges to catalysts for the hydrogen and oxygen evolution processes. Covalent triazine‐based frameworks (CTFs) represent an interesting class of 2D organic light‐absorbing materials that have recently emerged thanks to their tunable structural, optical and morphological properties. Typically, catalysts (Cat) are metallic nanoparticles generated in situ after photoelectroreduction of metal precursors or directly drop‐casted on top of the CTF material to generate Cat‐CTF assemblies. In this work, the synthesis, characterization and photocatalytic performance of a novel hybrid material, Ru‐CTF, is reported, based on a CTF structure featuring dangling pyridyl groups that allow the Ru‐tda (tda is [2,2′:6′,2′“‐terpyridine]‐6,6′”‐dicarboxylic acid) water oxidation catalyst (WOC) unit to coordinate via covalent bond. The Ru‐CTF molecular hybrid material can carry out the light‐induced water oxidation reaction efficiently at neutral pH, reaching values of maximum TOF of 17 h−1 and TONs in the range of 220 using sodium persulfate as a sacrificial electron acceptor.
Dual Oxygen‐Supply Immunosuppression‐Inhibiting Nanomedicine to Avoid the Intratumoral Recruitment of Myeloid‐Derived Suppressor Cells
Authors: Yang Zhengyang , Zuo Huaqin , Hou Yuchen , Zhou Shuqin , Zhang Ying , Yang Wanren , He Jian , Shen Xiaofei , Peng Qing 
Published: September 2024

AbstractMyeloid‐derived suppressor cells (MDSCs) are reported to be responsible for the negative prognosis of colorectal cancer (CRC) patients due to the mediated immunosuppressive tumor microenvironment (TME). The selective and chronic circumvention of tumor‐infiltrated MDSCs has potential clinical significance for CRC treatment, which unluckily remains a technical challenge. Because tumor hypoxia makes a significant contribution to the recruitment of MDSCs in tumor sites, a dual oxygen‐supplied immunosuppression‐inhibiting nanomedicine (DOIN) is demonstrated for overcoming tumor hypoxia, which achieves selective and long‐term inhibition of intratumoral recruitment of MDSCs. The DOIN is constructed by the encasement of perfluorooctyl bromide (PFOB) and 4‐methylumbelliferone (4‐MU) into a TME‐responsive amphiphilic polymer. This nanoplatform directly carries oxygen to the tumor region and simultaneously loosens the condensed tumor extracellular matrix for the normalization of tumor vasculature, which selectively remodels the TME toward one adverse to the intratumoral recruitment of MDSCs. Importantly, this nanoplatform offers a long‐acting alleviation of the hypoxic TME, chronically avoiding the comeback of tumor‐infiltrated MDSCs. Consequently, the immunosuppressive TME is relieved, and T cells are successfully proliferated and activated into cytotoxic T lymphocytes, which boosts a systemic immune response and contributes to lasting inhibition of tumor growth with a prolonged survival span of xenograft.
The decree of inclusive education and its potential for irritation for the educational system—A system‐theoretical conceptualization of the relationship between education and politics
Authors: Lindacher Tanja 
Published: September 2024

AbstractThe starting point of the argument is the assumption that the decree of inclusive education in Germany has received considerable impetus from national and international political developments, especially through the adoption of the Salamanca Statement and Framework for Action on Special Needs Education in 1994 and the ratification of the United Nations' Convention on the Rights of Persons with Disabilities in 2009. The immense pressure for reform, which is triggered by education policy's expectations, essentially means that the decree of inclusive education can be interpreted as an irritation for the specific constitution of the educational system. Against the background of the potential for irritation in the decree of inclusive education, it is shown to what extent the educational system recognizes differences in the sense of irritation and to what extent these are relevant when it observes its relationship to politics. The theoretical work of the article provides important information on how the relationship between education and politics can be conceptualized based on a concrete semantic context such as the decree of inclusive education.
Physicochemical, Structural, and Functional Properties of Cacahuacintle Maize Starch
Authors: López‐Vázquez Diana Edith , Lobato‐Calleros Consuelo , Hernández‐Rodríguez Landy , Aguirre‐Mandujano Eleazar , Alvarez‐Ramirez José , Vernon‐Carter Eduardo Jaime 
Published: September 2024

AbstractMaize is a valuable source of starch, but many genotypes still have not yet been studied. Thus, an ongoing research topic is to evaluate the physicochemical, structural, and functional properties of these understudied genotypes, such as is the case of the cacahuacintle maize genotype. Two cacahuacintle maize varieties MA1 and MA2, endogenous to the State of Mexico but from different locations, are used for obtaining maize starch (MS1 and MS2) and compared to a commercial normal maize starch (CS). Scanning electron microscopy (SEM) reveals that CS granules have polyhedral shape, while those for MS1 and MS2 are semi‐spherical. Fourier‐transform infrared (FTIR) spectra shows that the three starches exhibit the characteristic peaks of polysaccharides but display differences in the hydrated and ordered structures. X‐ray analysis reveals that all the starches have Type A pattern, but have different crystallinities, ranging from 21.07% to 25.37%. MS1 and MS2 exhibit higher values of solubility, swelling power, and water retention capacity compared to CS, but the latter has superior oil‐holding capacity. MS1 and MS2 have higher resistant starch fraction content than CS. The results show that cacahuacintle maize starch has a good application potential as an additive in food products.
Seismic performance of reinforced concrete stairs with new sliding support
Authors: Zhang Zheng , Cong Shuping , Zhang Yangang , Chen Yongtao 
Published: September 2024

AbstractCast‐in‐suit stairs and precast stairs were damaged seriously during many earthquakes in recent years. Stairs with new sliding support were put forward in order to avoid the failure of stairs, landing slab in the half floor was divided into two parts and sliding support was placed between stair beam and landing slab. Down‐scaled model of stairs with new sliding support was produced, and reversed cyclic loading test was conducted to investigate the failure mode, hysteretic behavior, ductility, stiffness degradation and energy dissipation. The failure mode was crushing damage of frame column and stair components remained intact. The new sliding support had good working properties and landing slab separated from stair beam under the pull condition. In addition, seven finite element models of staircase were developed to investigate the seismic performance of staircase, and seven finite element models of frame structure were developed to investigate the effect of stairs on the seismic performance of main structure. Lateral stiffness of the staircase was asymmetrical affected by common stairs, so torsional deformation of staircase was large, and stairs with new sliding support had no effect to the lateral stiffness of staircase. Compared with frame structure, the natural period of vibration decreased approximately by 5% and the first vibration mode also changed direction when common stairs was considered, the natural period of vibration and the first vibration mode were not change when sliding support was adopted. Stairs were not damaged and did not affect the seismic performance of main structure when new sliding support was used.