bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Nonhomogeneous Fractional p-Kirchhoff Type Problem Involving Critical Exponent in ℝ
N
Authors: Xiang Mingqi , Zhang Binlin , Zhang Xia 
Published: November 2016

Abstract
This paper concerns itself with the nonexistence and multiplicity of solutions for the following fractional Kirchhoff-type problem involving the critical Sobolev exponent:

[

a
+

b
⁢

(

∬

ℝ

2
⁢
N

|

u
⁢

(
x
)

-

u
⁢

(
y
)

|

p

|

x
-
y

|

N
+

p
⁢
s

⁢

𝑑

x

⁢

𝑑
y

)

θ
-
1

]

⁢

(

-
Δ

)

p
s

⁢
u

=

|
u
|

p
s
*

-
2

⁢
u

+

λ
⁢
f
⁢

(
x
)

in
⁢

ℝ
N

,

\Biggl{[}a+b\biggl{(}\iint_{\mathbb{R}^{2N}}\frac{\lvert u(x)-u(y)\rvert^{p}}{% \lvert x-y\rvert^{N+ps}}\,dx\,dy\biggr{)}^{\theta-1}\Biggr{]}(-\Delta)_{p}^{s}% u=\lvert u\rvert^{p_{s}^{*}-2}u+\lambda f(x)\quad\text{in }\mathbb{R}^{N},

where

a
≥
0

{a\kern-1.0pt\geq\kern-1.0pt0}

,

b
>
0

,

θ
>
1

{b\kern-1.0pt>\kern-1.0pt0,\theta\kern-1.0pt>\kern-1.0pt1}

,

(

-
Δ

)

p
s

{(-\Delta)_{p}^{s}}

is the fractional p-Laplacian with

0
<
s
<
1

{0\kern-1.0pt<\kern-1.0pts\kern-1.0pt<\kern-1.0pt1}

and

1
<
p
<

N
/
s

{1\kern-1.0pt<\kern-1.0ptp\kern-1.0pt<\kern-1.0ptN/s}

,

p
s
*

=

N
⁢
p

/

(

N
-

p
⁢
s

)

{p_{s}^{*}\kern-1.0pt=\kern-1.0ptNp/(N-ps)}

is the critical Sobolev exponent,

λ
≥
0

{\lambda\geq 0}

is a parameter, and

f
∈

L

p
s
*

/

(

p
s
*

-
1

)

⁢

(

ℝ
N

)

∖

{
0
}

{f\in L^{p_{s}^{*}/(p_{s}^{*}-1)}(\mathbb{R}^{N})\setminus\{0\}}

is a nonnegative function. When

λ
=
0

{\lambda=0}

, we show that the multiplicity and nonexistence of solutions for the above problem are related with N, θ, s, p, a, and b. When

λ
>
0

{\lambda>0}

, by using Ekeland’s variational principle and the mountain pass theorem, we show that there exists

λ

*
*

>
0

{\lambda^{**}>0}

such that the above problem admits at least two nonnegative solutions for all

λ
∈

(
0
,

λ

*
*

)

{\lambda\in(0,\lambda^{**})}

. In the latter case, in order to overcome the loss of compactness, we derive a fractional version of the principle of concentration compactness in the setting of the fractional p-Laplacian.
Vancomycin-induced thrombocytopenia in a newborn
Authors: Kalra Kunal , Mittal Hema Gupta , Maria Arti 
Published: November 2016

Abstract
Neonatal thrombocytopenia is common and is frequently seen in neonatal sepsis. Drug-induced thrombocytopenia is likely to be missed unless a high index of suspicion is present. Changing of antibiotics for assumed nonresolution of sepsis may lead to persistent thrombocytopenia in a neonate if drug-induced thrombocytopenia is missed. Vancomycin-induced neonatal thrombocytopenia is rarely described in scientific literature. We describe a newborn who was diagnosed with early onset sepsis and vancomycin-induced thrombocytopenia. Other causes of thrombocytopenia such as sepsis, alloimmune thrombocytopenia, thrombosis etc. were excluded. The platelet counts normalized within 72 h of stopping vancomycin. Vancomycin-induced IgM platelet antibodies could not be done in our case (due to financial constraints), but their absence does not exclude the diagnosis of vancomycin-induced thrombocytopenia.
Sorption/desorption hysteresis revisited. Sorption properties of Pinus pinea L. analysed by the parallel exponential kinetics and Kelvin-Voigt models
Authors: Simón Cristina , Esteban Luis García , Palacios Paloma de , Fernández Francisco García , García-Iruela Alberto 
Published: November 2016

Abstract
The hygroscopic properties of Pinus pinea L. wood at 35 and 50°C were investigated by the dynamic vapour sorption (DVS) technique. The sorption kinetic behaviour was studied through the parallel exponential kinetics (PEK) model, which is subdivided into a fast and a slow process. The parameters obtained by PEK were interpreted based on the Kelvin-Voigt (KV) model to determine elasticity and viscosity values of the wood cell wall. The PEK data perfectly fit the experimental data. The temperature-dependent transition between the fast and slow processes is fluent. The slow process contributes more to the total hysteresis of sorption. The kinetic properties varied in relation to the type of cycle and the temperature. The moduli of elasticity and viscosity were higher in the slow process than in the fast one. In both processes, the moduli showed a decreasing tendency in relation to relative humidity.
Novel mutations of the SRD5A2 and AR genes in Thai patients with 46, XY disorders of sex development
Authors: Ittiwut Chupong , Pratuangdejkul Jaturong , Supornsilchai Vichit , Muensri Sasipa , Hiranras Yodporn , Sahakitrungruang Taninee , Watcharasindhu Suttipong , Suphapeetiporn Kanya , Shotelersuk Vorasuk 
Published: November 2016

AbstractBackground:Abnormalities of dihydrotestosterone conversion [5α-reductase deficiency: online Mendelian inheritance in man (OMIM) 607306] or actions of androgens [partial androgen insensitivity syndrome (PAIS): OMIM 312300] during the 8th–12th weeks of gestation cause varying degrees of undervirilized external genitalia in 46, XY disorders of sex development (DSD) with increased testosterone production. The objective of the study was to determine clinical and genetic characteristics of Thai patients with 46, XY DSD.Methods:A cross-sectional study was conducted in 46, XY DSD with increased testosterone production (n=43) evaluated by a human chorionic gonadotropin (hCG) stimulation test or clinical features consistent with 5α-reductase deficiency or PAIS. PCR sequencing of the entire coding regions of theResults:Mutations were found in seven patients (16.3%): five (11.6%) and two (4.7%) patients had mutations inConclusions:Around 16.3% of our patients with 46, XY DSD had 5α-reductase deficiency or PAIS. Two novel mutations of
Growth curves for congenital adrenal hyperplasia from a national retrospective cohort
Authors: Bretones Patricia , Riche Benjamin , Pichot Emmanuel , David Michel , Roy Pascal , Tardy Véronique , Kassai Behrouz , Gaillard Ségolène , Bernoux Delphine , Morel Yves , Chatelain Pierre , Nicolino Marc , Cornu Catherine , for the French Collaborative CAH Gr  
Published: November 2016

Abstract

Background:
In congenital adrenal hyperplasia (CAH), adjusting hydrocortisone dose during childhood avoids reduced adult height. However, there are currently no CAH-specific charts to monitor growth during treatment. Our objective was to elaborate growth reference charts and bone maturation data for CAH patients.

Methods:
We conducted a retrospective observational cohort study, in 34 French CAH centers. Patients were 496 children born 1970–1991 with genetically proven 21-hydroxylase deficiency. Their growth and bone maturation data were collected until age 18 together with adult height, puberty onset, parental height, and treatment. The mean (SD) heights were modeled from birth to adulthood. The median±1 SD and ±2 SDs model-generated curves were compared with the French references. A linear model for bone maturation and a logistic regression model for the probability of short adult height were built.

Results:
Growth charts were built by sex for salt wasting (SW) and simple virilizing (SV) children treated before 1 year of age. In girls and boys, growth was close to that of the general French population up to puberty onset. There was almost no pubertal spurt and the mean adult height was shorter than that of the general population in girls (−1.2 SD, 156.7 cm) and boys (−1.0 SD, 168.8 cm). Advanced bone age at 8 years had a strong impact on the risk of short adult height (OR: 4.5 per year advance).

Conclusions:
The 8-year bone age is a strong predictor of adult height. It will help monitoring the growth of CAH-affected children.
Efficacy of micellized vs. fat-soluble vitamin D3 supplementation in healthy school children from Northern India
Authors: Marwaha Raman K. , Yenamandra Vamsi K. , Ganie Mohammed Asraf , Sethuraman Gomathy , Sreenivas Vishnubhatla , Ramakrishnan Lakshmy , Mathur Sathish K. , Sharma Vinod K. , Mithal Ambrish 
Published: November 2016

Abstract

Background:
Vitamin D deficiency is a widely recognized public health problem. Efficacy of a recently developed micellized form of vitamin D3 has not been studied. Hence, we undertook this study to compare its efficacy with the conventionally used fat-soluble vitamin D3.

Methods:
In this open-labeled nonrandomized pilot study, we recruited 180 healthy children, aged 13–14 years in two groups and supplemented Group A (60 children) with 60,000 IU of fat-soluble vitamin D3/month with milk and Group B (120 children) with 60,000 IU/month of water miscible vitamin D3 under supervision for 6 months. Serum 25(OD)D, parathyroid hormone (PTH), calcium, phosphate, and alkaline phosphatase (ALP) levels were evaluated before and after supplementation in 156 children (54 in Group A and 102 in Group B) who completed the study.

Results:
We observed a significantly greater increase in the serum 25(OH)D levels in group B as compared to group A (31.8±9.1 ng/mL vs. 23.7±10.4 ng/mL; p<0.001). All children in group B achieved adequate levels of serum 25(OH)D (>20 ng/mL) as against 83.3% children in group A. Serum PTH and ALP levels declined considerably in both the groups following supplementation.

Conclusions:
Vitamin D supplementation significantly increased the serum 25(OH)D levels in both groups. Miscible form of vitamin D3 appears to be better in achieving higher levels of serum 25(OH)D than that observed with a similar dose of fat-soluble vitamin D3. Further studies with different dose regimens are required to establish its efficacy over the conventionally used fat-soluble vitamin D3.
Cortisol response to adrenocorticotropin testing in non-classical congenital adrenal hyperplasia (NCCAH)
Authors: Karachaliou Fotini-Heleni , Kafetzi Maria , Dracopoulou Maria , Vlachopapadopoulou Elpis , Leka Sofia , Fotinou Aspasia , Michalacos Stefanos 
Published: November 2016

AbstractBackground:The adequacy of cortisol response in non-classical congenital adrenal hyperplasia (NCCAH) has not been fully elucidated. The aim was to evaluate cortisol response to adrenocorticotropin (ACTH) stimulation test in children and adolescents with NCCAH and heterozygotes forMethods:One hundred and forty-six children and adolescents, mean age 7.9 (0.7–17.5) years with clinical hyperandrogenism, were evaluated retrospectively. Thirty-one subjects had NCCAH, 30 were heterozygotes forResults:Baseline cortisol levels did not differ among NCCAH, heterozygotes, and normal responders: 15.75 (5.83–59.6) μg/dL vs. 14.67 (5.43–40.89) μg/dL vs. 14.04 (2.97–34.8) μg/dL, p=0.721. However, NCCAH patients had lower peak cortisol compared to heterozygotes and control group: 28.34 (12.25–84.40) vs. 35.22 (17.47–52.37) μg/dL vs. 34.92 (19.91–46.68) μg/dL, respectively, p=0.000. Peak cortisol was <18 μg/dL in 7/31 NCCAH patients and in one heterozygote.Conclusions:A percentage of 21.2% NCCAH patients showed inadequate cortisol response to ACTH stimulation. In these subjects, the discontinuation of treatment on completion of growth deserves consideration.
Crystal structure of (1,4,8,11-tetraazacyclotetradecane)palladium(II) tetracyanopalladate(II), C14H24N8Pd2
Authors: Ha Kwang 
Published: November 2016

Abstract
C14H24N8Pd2, monoclinic, P21/n (no. 14), a = 9.075(2) Å, b = 8.3534(19) Å, c = 12.106(3) Å, β = 94.895(4)°, V = 914.3(4) Å3, Z = 2, R
gt(F) = 0.0220, wR
ref(F
2) = 0.0654, T = 223(2) K.
Implementation of the Population Policy of Ethiopia: Achievements and Challenges
Authors: Hailemariam Assefa 
Published: November 2016

AbstractBackground: The Ethiopian government promulgated its first ever explicit, comprehensive and multisectoral population policy in 1993. The policy aimed at harmonizing population growth rate with that of the economy and the capacity of the country for sustainable socio-economic development. As with any population policy, there are important lessons to be learnt from the problems and challenges encountered during its implementation.Objective: The paper assesses the extent to which the population policy objectives have been realized; highlights the successes registered and identifies challenges encountered in its implementation and proposes the way forward.Methodology: Trend analysis using secondary data from censuses, surveys and UN sources were used and policy documents, research findings, development plan and program reports reviewed.Results: Fertility, infant, under-five and maternal mortality have declined significantly. Female participation in education and labour force increased. A range of legal, policy and institutional frameworks have been developed and implemented on environmental security and on gender equity, equality and the empowerment of women. Legislative measures were also taken to remove harmful traditional practices. However, the pace of implementation has been slow and there are areas where not much progress was made.Conclusion: Despite the progress made, there are critical challenges. Failure to establish the National Population Council; weak coordination and institutional arrangement due to absence of legally defined structure for implementation, lack of monitoring and evaluation system, absence of a comprehensive population program and financial constraints, among others are the major barriers. There is need to revise the policy and address these impediments and continuing and evolving challenges.
25 Years of Reports on Geodesy and Geoinformatics
Authors: Siemiątkowska Jadwiga 
Published: November 2016

Abstract
The article presents an outline of the 25-year history of the journal “Reports on Geodesy and Geoinformatics”. The source of information was mainly the journal issues themselves. Attention was drawn to changes that the journal underwent over a quarter of a century and its relationship with the Institute of Geodesy and Geodetic Astronomy and later the Department of Geodesy and Geodetic Astronomy. Many issues were dedicated to materials from Polish conferences - those organised by the Institute and the international ones attended by the employees of the Institute, which was indicated in the section on the history of the journal.
The second part of the article concerns the current activity and importance of the journal. Attention was paid to visibility of “Reports on Geodesy and Geoinformatics” in the domestic and foreign databases. Polish databases where the journal is indexed have been identified and briefly described. A separate issue is the evaluation of the journal, which forms a measure of its popularity among consumers. For this purpose, various parameters and biometrics indicators are used. The article used the Web of Science, Google Scholar and the Ministerial List databases for the assessment of the journal.
Laser Scanning in Engineering Surveying: Methods of Measurement and Modeling of Structures
Authors: Lenda Grzegorz , Uznański Andrzej , Strach Michał , Lewińska Paulina 
Published: November 2016

Abstract
The study is devoted to the uses of laser scanning in the field of engineering surveying. It is currently one of the main trends of research which is developed at the Department of Engineering Surveying and Civil Engineering at the Faculty of Mining Surveying and Environmental Engineering of AGH University of Science and Technology in Krakow. They mainly relate to the issues associated with tower and shell structures, infrastructure of rail routes, or development of digital elevation models for a wide range of applications. These issues often require the use of a variety of scanning techniques (stationary, mobile), but the differences also regard the planning of measurement stations and methods of merging point clouds. Significant differences appear during the analysis of point clouds, especially when modeling objects. Analysis of the selected parameters is already possible basing on ad hoc measurements carried out on a point cloud. However, only the construction of three-dimensional models provides complete information about the shape of structures, allows to perform the analysis in any place and reduces the amount of the stored data. Some structures can be modeled in the form of simple axes, sections, or solids, for others it becomes necessary to create sophisticated models of surfaces, depicting local deformations. The examples selected for the study allow to assess the scope of measurement and office work for a variety of uses related to the issue set forth in the title of this study. Additionally, the latest, forward-looking technology was presented - laser scanning performed from Unmanned Aerial Vehicles (drones). Currently, it is basically in the prototype phase, but it might be expected to make a significant progress in numerous applications in the field of engineering surveying.
Research and Development Work Carried out by the Chair of Engineering Geodesy and Measurement and Control Systems, Faculty of Geodesy and Cartography WUT – Thematic Scope and Achievements
Authors: Nowak Edward , Malarski Ryszard , Prószyński Witold , Sadowska Alicja , Woźniak Marek , Zaczek-Peplinska Janina 
Published: November 2016

Abstract
Geodetic engineering surveys are an important part of the works carried out by the Faculty of Geodesy and Cartography, Warsaw University of Technology. These works concern measurement techniques as well as advanced result analysis methods applied in precise industrial surveys and in processes controlling object’s behaviour over time.
The thematic scope of research realised by Chair of Engineering Geodesy and Control-Measuring Systems shows that article related to geodetic engineering measurements and geodetic monitoring is carried out with high intensity, resulting in technological advancement and implementation of new or improved measurement solutions and methods of measurement result development.
Novel tetrazole derivatives: synthesis, anticholinesterase activity and cytotoxicity evaluation
Authors: Yurttaş Leyla , Kaplancıklı Zafer Asım , Temel Halide Edip , Çiftçi Gülşen Akalın 
Published: November 2016

Abstract

Objective(s)
The synthesis of new N′-arylidene-4-[(1-phenyl-1H-tetrazole-5-yl)thio]butanoylhydrazide derivatives (1–26) and investigation of their potential anticholinesterase (AChE), butyrylcholinesterase (BuChE) enzyme inhibition activities and also cytotoxic properties on mouse embryonic fibroblast cells (NIH/3T3) were aimed in this work.

Materials and methods
The target compounds were prepared by a three step synthetic procedure using 1-phenyl-1H-tetrazole-5-thiol and ethyl 4-chlorobutanoate as starting materials. The structures of the obtained compounds were elucidated by IR, 1H-NMR, 13C-NMR spectra and elemental analysis data. The enzyme inhibition and cytotoxic activities were determined according to Ellman and MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] methods, respectively.

Results
Compounds 14, 15 and compound 18 exhibited the highest inhibitory activity on AChE and BuChE enzymes. Additionally, compounds 4, 5, 8 and 16 exhibited the lowest cytotoxicity against NIH/3T3 cells.

Conclusion
Compounds 14, 15 and 18 bearing 2-nitro, 3-nitro and 3-hydroxy substituents have showed selective enzyme inhibitory activities.
Neurophysiological Organization of the Middle Face Patch in Macaque Inferior Temporal Cortex
Authors: Aparicio Paul L. , Issa Elias B. , DiCarlo James J. 
Published: November 2016

While early cortical visual areas contain fine scale spatial organization of neuronal properties, such as orientation preference, the spatial organization of higher-level visual areas is less well understood. The fMRI demonstration of face-preferring regions in human ventral cortex and monkey inferior temporal cortex (“face patches”) raises the question of how neural selectivity for faces is organized. Here, we targeted hundreds of spatially registered neural recordings to the largest fMRI-identified face-preferring region in monkeys, the middle face patch (MFP), and show that the MFP contains a graded enrichment of face-preferring neurons. At its center, as much as 93% of the sites we sampled responded twice as strongly to faces than to nonface objects. We estimate the maximum neurophysiological size of the MFP to be ∼6 mm in diameter, consistent with its previously reported size under fMRI. Importantly, face selectivity in the MFP varied strongly even between neighboring sites. Additionally, extremely face-selective sites were ∼40 times more likely to be present inside the MFP than outside. These results provide the first direct quantification of the size and neural composition of the MFP by showing that the cortical tissue localized to the fMRI defined region consists of a very high fraction of face-preferring sites near its center, and a monotonic decrease in that fraction along any radial spatial axis.SIGNIFICANCE STATEMENTThe underlying organization of neurons that give rise to the large spatial regions of activity observed with fMRI is not well understood. Neurophysiological studies that have targeted the fMRI identified face patches in monkeys have provided evidence for both large-scale clustering and a heterogeneous spatial organization. Here we used a novel x-ray imaging system to spatially map the responses of hundreds of sites in and around the middle face patch. We observed that face-selective signal localized to the middle face patch was characterized by a gradual spatial enrichment. Furthermore, strongly face-selective sites were ∼40 times more likely to be found inside the patch than outside of the patch.
Deficiency of CPEB2-Confined Choline Acetyltransferase Expression in the Dorsal Motor Nucleus of Vagus Causes Hyperactivated Parasympathetic Signaling-Associated Bronchoconstriction
Authors: Lai Yen-Ting , Su Chun-Kuei , Jiang Si-Tse , Chang Ya-Jen , Lai Alan Chuan-Ying , Huang Yi-Shuian 
Published: November 2016

Cytoplasmic polyadenylation element binding protein 2 (CPEB2) is an RNA-binding protein and translational regulator. To understand the physiological function of CPEB2, we generated CPEB2 knock-out (KO) mice and found that most died within 3 d after birth. CPEB2 is highly expressed in the brainstem, which controls vital functions, such as breathing. Whole-body plethysmography revealed that KO neonates had aberrant respiration with frequent apnea. Nevertheless, the morphology and function of the respiratory rhythm generator and diaphragm neuromuscular junctions appeared normal. We found that upregulated translation of choline acetyltransferase in the CPEB2 KO dorsal motor nucleus of vagus resulted in hyperactivation of parasympathetic signaling-induced bronchoconstriction, as evidenced by increased pulmonary acetylcholine and phosphorylated myosin light chain 2 in bronchial smooth muscles. Specific deletion of CPEB2 in cholinergic neurons sufficiently caused increased apnea in neonatal pups and airway hyper-reactivity in adult mice. Moreover, inhalation of an anticholinergic bronchodilator reduced apnea episodes in global and cholinergic CPEB2-KO mice. Together, the elevated airway constriction induced by cholinergic transmission in KO neonates may account for the respiratory defect and mortality.SIGNIFICANCE STATEMENTThis study first generated and characterizedcpeb2gene-deficient mice. CPEB2-knock-out (KO) mice are born alive but most die within 3 d after birth showing no overt defects in anatomy. We found that the KO neonates showed severe apnea and altered respiratory pattern. Such respiratory defects could be recapitulated in mice with pan-neuron-specific or cholinergic neuron-specific ablation of thecpeb2gene. Further investigation revealed that cholinergic transmission in the KO dorsal motor nucleus of vagus was overactivated because KO mice lack CPEB2-suppressed translation of the rate-limiting enzyme in the production of acetylcholine (i.e., choline acetyltransferase). Consequently, increased parasympathetic signaling leads to hyperactivated bronchoconstriction and abnormal respiration in the KO neonates.