bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer survivorship care in rural community: Patient perspective.
Authors: Noyes Katia , Holub David , Rizvi Irfan , Swanger Alex , Reisdorf Coty , Tomaszewski Kenneth , Constine Louis S. 
Published: March 2017

25 Background: Advances in oncologic sciences have resulted in successful treatments for many cancers with improved event-free and overall survival for millions of patients. Efficient delivery of state of the art cancer care requires well-orchestrated performances of multiple oncology, primary care and social services providers. However, many rural oncology providers do not offer such multidisciplinary cancer services and rely on patients to coordinate their own care. This study assessed perspectives of rural cancer patients and caregivers on their confidence to make decisions and address their care needs. Methods: We conducted focus groups with the attendees of 3 rural Congregate Meals. The county-sponsored programs bring together seniors for nutritional meals, social connectedness and educational programs. We also developed and piloted a 5-question survey, asking respondents to rate their confidence in interacting with their clinicians about care needs, care coordination and barriers to care. Results: Overall, 85 individuals participated in the focus groups and 76 persons returned the survey (90% response rate). The vast majority of the participants were cancer survivors or caregivers to patients with cancer. Transportation to and from oncology appointments presents a major concern for the rural communities, as most patients had to travel long distance to see a doctor. Patients also reported having difficulty making decisions regarding their care due to a lack of knowledge about specific cancer services and limited availability of providers. Cancer support groups, behavioral health providers, exercise and nutrition therapies were reported to be particularly scarce in rural areas. We found that patients who had trusted relationships with their physicians tended to be more confident in their ability to obtain necessary help from their providers compared to patients who reported poor communication and lack of trust. Conclusions: There are numerous reasons that may lead to rural-urban disparities in cancer survivorship outcomes including limited availability of supportive services, limited patient resources, burden of patient decision making and care coordination, and lack of adequate patient-provider communication.
The evolving role of the primary care provider in the comprehensive cancer care paradigm: Knowledge, attitudes, beliefs, and practices of primary care clinicians.
Authors: Van Londen G J. , Brufsky Jill Weiskopf , Parker Ira Russell 
Published: March 2017

28 Background: Due to increasing numbers of individuals diagnosed with cancer, a burgeoning cohort of cancer survivors with significant medical co-morbidities, and oncology workforce challenges, the optimal integration of Primary Care Providers (PCPs) into the comprehensive cancer care paradigm is of timely importance. The goal of this investigation is to determine the knowledge, attitudes, beliefs, and practices of primary care clinicians -- pertaining to their existing and potential roles in cancer care. Methods: 1,069 clinical affiliates of the University of Pittsburgh Medical Center, who provide primary care services (e.g. Cardiology, Family Medicine, Geriatric Medicine, Gynecology, and Internal Medicine), were invited to participate in a 77-question, IRB-approved, online survey questionnaire [Qualtrics (Provo, Utah)]. Three “reminder emails” were generated. Results: Note: These results reflect the analysis of an initial, preliminary subset of survey responders (N=90). The full data set will be utilized for the final poster presentation. Eighty percent of the responders are physicians. Seventy-one percent reported that 50%+ of their time is spent providing primary care services and 66% have been in-practice for 15+ years. 73%, 63% and 59% respectively have participated in “cancer surveillance”, “cancer treatment/disease-related adverse event (AE) monitoring”, and “AE management” activities. Cardiotoxicity (42%), lymphedema (61%), and vasomotor flushing (63%) represented those AEs that the responders felt least comfortable monitoring independently. Twelve percent were aware of the PCP-targeted December/2015 “ACS-ASCO Breast Cancer Guideline” and 24% of the term “Survivorship Care Plan”. Twenty-two percent were “very confident” with regard to conducting a “low dose CT” lung cancer screening decision-making patient conversation. Twenty-one percent felt that their formal training did not adequately prepare them and that their present educational opportunities are inadequate pertaining to PCP-Cancer Survivorship issues. “Communication between the Oncology Team and PCP” was noted as the most stated “major issue”. Conclusions: To fully optimize the interface between Oncologists and PCPs with regard to best practices cancer care, strategies targeting competency training, enhanced information/guideline dissemination, and the development of collaborative-based delivery models will likely be necessary.
Methylprednisolone Therapy in Acute Traumatic Spinal Cord Injury: Analysis of a Regional Spinal Cord Model Systems Database
Authors: Sunshine Jacob E. , Dagal Armagan , Burns Stephen P. , Bransford Richard J. , Zhang Fangyi , Newman Shu-Fang , Nair Bala G. , Sharar Sam R. 
Published: March 2017

BACKGROUND:
The objective of this study was to assess the relationship between exposure to methylprednisolone (MP) and improvements in motor function among patients with acute traumatic spinal cord injury (TSCI). MP therapy for patients with TSCI is controversial because of the current conflicting evidence documenting its benefits and risks.

METHODS:
We conducted a retrospective cohort study from September 2007 to November 2014 of 311 patients with acute TSCI who were enrolled into a model systems database of a regional, level I trauma center. We linked outcomes and covariate data from the model systems database with MP exposure data from the electronic medical record. The primary outcomes were rehabilitation discharge in American Spinal Injury Association (ASIA) motor scores (sum of 10 key muscles bilaterally as per International Standards for Neurological Classification of Spinal Cord Injury, range, 0–100) and Functional Independence Measure (FIM) motor scores (range, 13–91). Secondary outcomes measured infection risk and gastrointestinal (GI) complications among MP recipients. For the primary outcomes, multivariable linear regression was used.

RESULTS:
There were 160 MP recipients and 151 nonrecipients. Adjusting for age, sex, weight, race, respective baseline motor score, surgical intervention, injury level, ASIA Impairment Scale (AIS) grade, education, and insurance status, there was no association with improvement in discharge ASIA motor function or FIM motor score among MP recipients: −0.34 (95% CI, −2.8, 2.1) and 0.75 (95% CI, −2.8, 4.3), respectively. Adjusting for age, sex, race, weight, injury level, and receipt of surgery, no association with increased risk of infection or GI complications was observed.

CONCLUSIONS:
This retrospective cohort study involving patients with acute TSCI observed no short-term improvements in motor function among MP recipients compared with nonrecipients. Our findings support current recommendations that MP use in this population should be limited.
Refilins are short-lived Actin-bundling proteins that regulate lamellipodium protrusion dynamics
Authors: Gay Olivia , Gilquin Benoît , Assard Nicole , Stuelsatz Pascal , Delphin Christian , Lachuer Joël , Gidrol Xavier , Baudier Jacques 
Published: March 2017

ABSTRACT
Refilins (RefilinA and RefilinB) are members of a novel family of Filamin binding proteins that function as molecular switches to conformationally alter the Actin filament network into bundles. We show here that Refilins are extremely labile proteins. An N-terminal PEST/DSG(X)2-4S motif mediates ubiquitin-independent rapid degradation. A second degradation signal is localized within the C-terminus. Only RefilinB is protected from rapid degradation by an auto-inhibitory domain that masks the PEST/DSG(X)2-4S motif. Dual regulation of RefilinA and RefilinB stability was confirmed in rat brain NG2 precursor cells (polydendrocyte). Using loss- and gain-of-function approaches we show that in these cells, and in U373MG cells, Refilins contribute to the dynamics of lamellipodium protrusion by catalysing Actin bundle formation within the lamella Actin network. These studies extend the Actin bundling function of the Refilin-Filamin complex to dynamic regulation of cell membrane remodelling.
Script as a hypothesis: Scriptwriting for documentary film
Authors: Aaltonen Jouko 
Published: March 2017

Abstract
Writing the script for a documentary film can be problematic. According to some documentary filmmakers, it is not possible at all, because one cannot know beforehand what is going to happen. Nonetheless, a written script is often required to obtain financing for a documentary project. This article deals with different work practices and forms of documentary script. It analyses two case studies: the writer’s own films A Man from the Congo River (2010) and Kusum (2000). The first is the story of an engineer who worked in colonial Congo at the beginning of the twentieth century. It is based on diaries and other historical material, and therefore it was possible to construct a very precise script for the film. Kusum is an observational documentary film following the healing of a young Indian girl. The script was produced prior to production, but during the shooting process many core elements changed, including the main character and storyline. The form and dramaturgy of documentary films are created in the filmmaking process and in dialogue between the filmmaker and real people. A documentary script can be considered a hypothesis about the reality that the filmmaker will encounter via the process of filmmaking. Instead of ‘a screen idea’ we could speak about ‘a documentary idea’.
Differences in the stratum corneum of Indonesian infants and adults
Authors: Fujimura Tsutomu , Shima Kyoko , Miyauchi Yuki , Hotta Mitsuyuki , Hashimoto Hiroshi , Yunaidi Danang Agung , Putri Ratih Sofia Ika , Ningrum Puspita , Takema Yoshinori 
Published: March 2017

Background Although understanding the stratum corneum (SC) of infant skin is important to avoid skin diseases such as atopic dermatitis, there has been no such investigation in Indonesian infants to date.Objective To obtain a basic knowledge of SC characteristics in Indonesian infants in order to develop methods for infant-specific skin care and to prevent dermatitis and infection.Methods Seventy-two healthy, full term infants aged 1 to 24 months who were native Indonesians residing in Jakarta were enrolled in this study. Some of the mothers were also enrolled in the study as adults (n=30). Transepidermal water loss (TEWL) and hydration of the SC (capacitance) on the thigh, buttock, and upper arm were measured after sufficient acclimation in an air-conditioned room, in both infants and mothers. Results The SC hydration was significantly higher in infants than adults at all sites measured, including the buttocks, which is a diaper area. Infant TEWL values were also significantly higher than in adults at all sites. Hydration of the SC and TEWL values showed no significant correlation with age of infant for any site. The SC hydration and TEWL values of Indonesian infants did not decrease to adult values within 24 months, which indicates that the SC characteristics in infants continue to develop after 24 months of age.Conclusion Indonesian infants aged 0-24 months have significantly higher SC hydration and TEWL values than Indonesian mothers. However, infant age has no correlation to SC hydration or to TEWL values.
Estrogen maintains mitochondrial content and function in the right ventricle of rats with pulmonary hypertension
Authors: Liu Aiping , Philip Jennifer , Vinnakota Kalyan C. , Van den Bergh Francoise , Tabima Diana M. , Hacker Timothy , Beard Daniel A. , Chesler Naomi C. 
Published: March 2017

AbstractThe typical cause of death in pulmonary hypertension (PH) is right ventricular (RV) failure, with females showing better survival rates than males. Recently, metabolic shift and mitochondrial dysfunction have been demonstrated in RV failure secondary to PH. In light of evidence showing that estrogen protects mitochondrial function and biogenesis in noncardiovascular systems, we hypothesized that the mechanism by which estrogen preserves RV function is via protection of mitochondrial content and oxidative capacity in PH. We used a well‐established model of PH (Sugen+Hypoxia) in ovariectomized female rats with/without estrogen treatment. RV functional measures were derived from pressure–volume relationships measured via RV catheterization in live rats. Citrate synthase activity, a marker of mitochondrial density, was measured in both RV and LV tissues. Respiratory capacity of mitochondria isolated from RV was measured using oxygraphy. We found that RV ventricular‐vascular coupling efficiency decreased in the placebo‐treated SuHx rats (0.78 ± 0.10 vs. 1.50 ± 0.13 in control, P < 0.05), whereas estrogen restored it. Mitochondrial density decreased in placebo‐treated SuHx rats (0.12 ± 0.01 vs. 0.15 ± 0.01 U citrate synthase/mg in control, P < 0.05), and estrogen attenuated the decrease. Mitochondrial quality and oxidative capacity tended to be lower in placebo‐treated SuHx rats only. The changes in mitochondrial biogenesis and function paralleled the expression levels of PGC‐1α in RV. Our results suggest that estrogen protects RV function by preserving mitochondrial content and oxidative capacity. This provides a mechanism by which estrogen provides protection in female PH patients and paves the way to develop estrogen and its targets as a novel RV‐specific therapy for PH.
Trunk muscle activation during movement with a new exercise device for lumbo‐pelvic reconditioning
Authors: Weber Tobias , Debuse Dorothée , Salomoni Sauro E. , Elgueta Cancino Edith L. , De Martino Enrico , Caplan Nick , Damann Volker , Scott Jonathan , Hodges Paul W 
Published: March 2017

AbstractGravitational unloading leads to adaptations of the human body, including the spine and its adjacent structures, making it more vulnerable to injury and pain. The Functional Re‐adaptive Exercise Device (FRED) has been developed to activate the deep spinal muscles, lumbar multifidus (LM) and transversus abdominis (TrA), that provide inter‐segmental control and spinal protection. The FRED provides an unstable base of support and combines weight bearing in up‐right posture with side alternating, elliptical leg movements, without any resistance to movement. The present study investigated the activation of LM, TrA, obliquus externus (OE), obliquus internus (OI), abdominis, and erector spinae (ES) during FRED exercise using intramuscular fine‐wire and surface EMG. Nine healthy male volunteers (27 ± 5 years) have been recruited for the study. FRED exercise was compared with treadmill walking. It was confirmed that LM and TrA were continually active during FRED exercise. Compared with walking, FRED exercise resulted in similar mean activation of LM and TrA, less activation of OE, OI, ES, and greater variability of lumbo‐pelvic muscle activation patterns between individual FRED/gait cycles. These data suggest that FRED continuously engages LM and TrA, and therefore, has the potential as a stationary exercise device to train these muscles.
Wintering sites of Wallcreeper Tichodroma muraria on the east Adriatic coast
Authors: Lukač Gordan , Vujčić-Karlo Snježana , Ružanović Zlatko , Adžić Ivana , Milovac Marijan , Stelko Roberto 
Published: March 2017

Abstract
Wallcreeper Tichodroma muraria was observed during cold winters in different parts of Croatia, along the Adriatic coast, on islands as well as inland. Their origin remains unknown, but they may belong to the population nesting in the Alps or in Dinaric parts of Bosnia and Herzegovina and Montenegro. The overwintering along the Adriatic coast was explored during field observations, but also from the literature and museum data. The field investigations were carried out in Istria, North Dalmatia, Paklenica NP, Kornati NP and central Dalmatia, Krka NP. In total, 96 observations were made: 35 specimens from museum collections and literature and 61 during field research. The Wallcreeper was observed in Velika and Mala Paklenica canyons in Paklenica NP during cold winters, but not during milder winters. In the Paklenica NP, the earliest individuals were observed on 10 Oct and the latest on 28 Apr. On the complete east Adriatic coast and in Croatian inland, the earliest record was made on 6 Sep and the latest on 2 May. There are 5-10 individuals overwintering in Paklenica National Park.
Application of Interval Arithmetic to Production Planning in a Foundry
Authors: Duda J. , Stawowy A. 
Published: March 2017

Abstract
A novel approach for treating the uncertainty about the real levels of finished products during production planning and scheduling process is presented in the paper. Interval arithmetic is used to describe uncertainty concerning the production that was planned to cover potential defective products, but meets customer’s quality requirement and can be delivered as fully valuable products. Interval lot sizing and scheduling model to solve this problem is proposed, then a dedicated version of genetic algorithm that is able to deal with interval arithmetic is used to solve the test problems taken from a real-world example described in the literature. The achieved results are compared with a standard approach in which no uncertainty about real production of valuable castings is considered. It has been shown that interval arithmetic can be a valuable method for modeling uncertainty, and proposed approach can provide more accurate information to the planners allowing them to take more tailored decisions.
Preliminary Tests of Cellular SiC/Iron Alloy Composite Produced by a Pressureless Infiltration Technique
Authors: Lipowska B. , Psiuk B. , Cholewa M. , Kozakiewicz Ł. 
Published: March 2017

Abstract
Preliminary tests aimed at obtaining a cellular SiC/iron alloy composite with a spatial structure of mutually intersecting skeletons, using a porous ceramic preform have been conducted. The possibility of obtaining such a composite joint using a SiC material with an oxynitride bonding and grey cast iron with flake graphite has been confirmed. Porous ceramic preforms were made by pouring the gelling ceramic suspension over a foamed polymer base which was next fired. The obtained samples of materials were subjected to macroscopic and microscopic observations as well as investigations into the chemical composition in microareas. It was found that the minimum width of a channel in the preform, which in the case of pressureless infiltration enables molten cast iron penetration, ranges from 0.10 to 0.17 mm. It was also found that the ceramic material applied was characterized by good metal wettability. The ceramics/metal contact area always has a transition zone (when the channel width is big enough), where mixing of the components of both composite elements takes place.
The Evaluation of Mechanical Properties of High-tin Bronzes
Authors: Nadolski M. 
Published: March 2017

Abstract
High-tin bronzes are used for church bells and concert bells (carillons). Therefore, beside their decorative value, they should also offer other functional properties, including their permanence and good quality of sound. The latter is highly influenced by the structure of bell material, i.e. mostly by the presence of internal porosity which interferes with vibration of the bell waist and rim, and therefore should be eliminated. The presented investigations concerning the influence of tin content ranging from 20 to 24 wt% on mechanical properties of high-tin bronzes allowed to prove the increase in hardness of these alloys with simultaneous decrease in the tensile and the impact strengths (Rm and KV, respectively) for the increased tin content. Fractures of examined specimens, their porosity and microstructures were also assessed to explain the observed regularities. A reason of the change in the values of mechanical properties was revealed to be the change in the shape of α-phase crystals from dendritic to acicular one, and generation of grain structure related to the increased Sn content in the alloy.
Assessment of Mechanism of Pore Formation in Directionally Solidified A356 Alloy
Authors: Uludağ M. , Dişpinar D. 
Published: March 2017

Abstract
It is well-known that the better the control of the liquid aluminium allows obtaining of better properties. One of the most important defects that is held responsible for lower properties has been the presence of porosity. Porosity has always been associated with the amount of dissolved hydrogen in the liquid. However, it was shown that hydrogen was not the major source but only a contributor the porosity. The most important defect that causes porosity is the presence of bifilms. These defects are surface entrained mainly due to turbulence and uncontrolled melt transfer. In this work, a cylindrical mould was designed (Ø30 x 300 mm) both from sand and die. Moulds were produced both from sand and die. Water cooled copper chill was placed at the bottom of the mould in order to generate a directional solidification. After the melt was prepared, prior to casting of the DC cast samples, reduced pressure test sample was taken to measure the melt quality (i.e. bifilm index). The cast parts were then sectioned into regions and longitudinal and transverse areas were investigated metallographically. Pore size, shape and distribution was measured by image analysis. The formation of porosity was evaluated by means of bifilm content, size and distribution in A356 alloy.
Application of FEM Analysis for Evaluation of the Stress and Deformation Distributions in the Top Layer of A390.0 Alloy During Friction
Authors: Wieszała R. , Piątkowski J. , Bąkowski H. 
Published: March 2017

Abstract
The paper presents an analysis of the effect of shape of primary silicon crystals on the sizes of stresses and deformations in a surface layer of A390.0 alloy by Finite Elements Method (FEM). Analysis of stereological characteristics of the studied alloy, performed based on a quantitative metallographic analysis in combination with a statistical analysis, was used for this purpose. The presented simulation tests showed not only the deposition depth of maximum stresses and strains, but also allowed for determining the aforementioned values depending on the shape of the silicon crystals. The studied material is intended for pistons of internal combustion engines, therefore the analysis of the surface layer corresponded to conditions during friction in a piston-cylinder system of an internal combustion engine having power of up to 100 kW. The obtained results showed important differences in the values of stresses and strains up to 15% between various shape of the silicon crystals. Crystals with sharp edges caused higher stresses and deformation locally than those with rounded shapes.