bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formulation Variables Influencing the Development of Ketoconazole Gastroretentive Drug Delivery System
Authors: Al Hablawi Moamin Fattah , Jaffar Iman Sabah 
Published: September 2024

Background: Ketoconazole (KZ) is categorized as class II according to the Biopharmaceutics Classification System (BSC) classification, which shows a strong pH-dependent solubility where its solubility is enhanced under an acidic medium (pH below 3). This strong pH dependence results in unpredictable absorption and a wide range of bioavailabilities. Objective: To prolong the gastric residence time of KZ’s tablet to enhance KZ’s solubility and hence its bioavailability for better therapeutic activity. Methods: To prepare mucoadhesive tablets, we use both direct and wet granulation methods. We employed various evaluation tests to assess the prepared tablets. These tests encompass a range of assessments, including weight variation, hardness, thickness, friability, disintegration test, swelling study, mucoadhesive strength study, and in vitro drug release studies. Results: The study found that polymer viscosity, as well as polymer concentration, have a significant effect on mucoadhesive strength and drug release, whereas diluent type has a non-significant influence on drug release. We selected Formula 7, which employs xanthan gum as a mucoadhesive polymer in a 1:1 drug polymer ratio, as the optimum formula because it provides an accepted physico-mechanical property and releases 87% of the drug over 8 hours. Conclusions: Gastric mucoadhesive tablets may be an effective method of delivering active ingredients, as they provide a favorable environment that enhances their dissolution by extending their duration in the stomach, thereby increasing their bioavailability.
Neutrophil/Lymphocyte and Platelet/lymphocyte Ratios as Predictors of Patient Response to Bevacizumab in Iraqi Patients with Metastatic Colorectal Cancer
Authors: Faris Rasha Mahroos , Mohammed Mohammed Mahmood , Delan Ayman Adnan 
Published: September 2024

Background: Global clinical trials have shown that bevacizumab, along with chemotherapy, is beneficial for people with metastatic colorectal cancer (mCRC). Nevertheless, there isn't a useful biomarker to predict its effectiveness. Objectives: The study's goal was to analyze and evaluate the practical pretreatment biomarker in people with metastatic colorectal cancer (mCRC) to predict bevacizumab efficacy. Methods: This study, which is retrospective, includes 157 patients diagnosed with mCRC who received bevacizumab in association with chemotherapy from three centers in Iraq. The study looked at how clinical data and biomarkers relate to disease control (DC), overall survival (OS), and progression-free survival (PFS). It also looked at how well they could predict these outcomes. The cutoff values of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were examined with ROC analysis. Results: For all patients, the median follow-up duration was 12 months. The PLR, NLR and median alkaline phosphatase (ALP) values were considerably lower in disease-control (DC) patients than in non-DC patients. The carcinoembryonic antigen (CEA) baseline level significantly correlated with shorter OS, while the ALP baseline level did not significantly correlate with shorter PFS. Among the clinical data, only multiple organ metastases showed a strong correlation with a shorter PFS and OS. Conclusions: A low pretreatment N/L ratio and P/L ratio might be good predictors of bevacizumab efficacy for metastatic colorectal cancer patients, and it could be clinically useful for choosing responders.
Perkembangan Psikologi Siswa: Studi terhadap Harapan Orang Tua Tunggal
Authors: Affa Rima Faiqotul , Hidayat Rian Rokhmad 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui bagaimana perkembangan pendidikan siswa bagi harapan orang tua tunggal. Penelitian ini menggunakan pendekatan kualitatif dengan desain studi kasus, subjek penelitian ini dengan kriteria laki-laki usia 16 tahun yang memiliki orang tua tunggal akibat perceraian. Pola Asuh orang tua memengaruhi perkembangan Pendidikan siswa, khususnya dalam hal kemampuan mengendalikan diri, prilaku dan motivasi belajar. Pengumpulan data menggunakan menggunakan metode observasi, wawancara dan dokumentasi. Hasil penelitian pada subjek menunjukkan bahwa pengasuhan orang tua tunggal menggunakan pola asuh dan berdampak pada ketidak mampuan untuk mengendalikan diri dan perilaku yang kurang baik. Subjek sangat sulit untuk menahan rasa malas, melanggar aturan sekolah dengan membolos pelajaran sekolah, mengganggu teman, tidak mengerjakan tugas, tidak memperhatikan pelajaran, dan mudah menyerah pada saat menghadapi kesulitan serta kurang mau berusaha dan kurang memiliki daya juang.
Rainfall modeling with CMIP6-DCPP outputs and local characteristic information using eigenvector spatial filtering varying coefficient (ESF-VC)
Authors: MAHKYA DANI AL , DJURAIDAH ANIK , WIGENA AJI HAMIM , SARTONO BAGUS 
Published: September 2024

Estimating rainfall at a point or region is difficult because complex factors affect rainfall. A helpful strategy is to utilize the GCM output information from CMIP6-DCPP by forming a functional relationship between GCM output data and rainfall data at a certain point or region, called statistical downscaling. However, because the resolution of the GCM output is relatively low, the model could not explain the local effects since the heterogeneity is enormous. Based on this fact, the current research proposes to add some local characteristics in the downscaling model to improve the performance to predict the rainfall levels. Further, the rainfall levels have spatial dependencies among points. Therefore, this research employed the Eigenvector Spatial Filtering-Varying Coefficient (ESF-VC) as the methodology of the modeling. The objective of this research is to perform rainfall predictive modeling with CMIP6-DCPP output and some local characteristic information as predictors using ESF-VC methodology. The approach was implemented to predict the rainfall level in the Province of Riau in Indonesia. Based on the results, the ESF-VC model provides good performance in estimating rainfall in Riau. The variables that provide local effects are altitude, equator (location), equator (distance), and wet month dummy. While the variables ENSO and vegetation (NDVI) have a significant global effect on the model.
Analisa Ratio lancar Dan Perputaran Piutang Terhadap Tingkat Pengembalian Asset Bisnis Makanan Dan Minuman Yang Tercatat Di Pasar Modal Indonesia
Authors: Nasution Yuslinda , Sawitry Ina , Noviarti  
Published: September 2024

ABSTRAK

Penelitian bertujuan mengevalusi dampak rasio lancar dan perputaran piutang kepada tahap pengembalian asset bisnis Food and beverage yang ada di Pasar Modal Indonesia (BEI) periode 2019 – 2022 secara terpisah dan bersama – sama. Populasi penelitian terdiri dari 84 perusahaan dan 24 perusahaan di jadikan sample menggunakan metode pertimbangan (kriteria ) tertentu.Hasil pengujian menjelaskan bahwa asset lancar memiliki dampak berbanding lurus kepada tingkat pengenbalian asset ,dimana t tabel (3,272 ≥ 1,98552 ) pada tingkat signifikansi 0,002.Sementara itu,perputaran piutang juga secara individu berpengaruh terhadap ROA,dengan hasil t tabel ( 2,142 ≥ 1,98552 ) dengan level signifikansi 0,035. Secara keseluruhan, ratio lancar dan perputaran piutang memilki pengaruh terhadap ROA sebesar 6,957 pada tingkat signifikansi 0,002.Hasil koefisien determinasi (R2 ) bahwa menunjukkan pengaruh current ratio dan perputaran piutang terhadap ROA sebesar 0,111menandakan bahwa 11% variasi dalam ROA dapat dijelaskan oleh kedua variabel tersebut. Dan 89% diluar dari variabel yang diteliti.

Kata kunci : Ratio Lancar ,Perputaran Piutang,ROA
Socialisation, social change and ideology in adult education
Authors: O'Sullivan Denis 
Published: September 2024

In this article I hope to outline some concepts from adult sociali sation theory and demonstrate their utility for the way we think about adult education, particularly in relation to social change and ideology. The article has been occasioned by the author's attempt to grapple with the probl em of valueimposition in relation to a social studies course he has been teaching for a number of years.
The Impact of a Natural Disaster on Classroom Curricula
Authors: Zevenbergen Andrea A. , Sigler Ellen A. , Duerre Lori J. , Howse Eva 
Published: September 2024

This study examines classroom curricula and activities in the academic year sub sequent to a flooding disaster that led to school being canceled five week s before the usual end of the academic year. Fifty- seven elementary school teachers from five schools provided information regarding alterations they ma de in their curriculum in the academic year subsequent to the flood. Curricular adjustments took the form of additional review of information from the previous academic year and integration of flood related information into classroom curricula. Curricular adjustments made by teachers were found to vary as a function of the grade taught. Teachers in the earlies t grades made more alterations in their reading, writing, and expressive language instruction as compared to teachers in the more advanced grades. Teachers in the more advanced grades made more alterations in mathematics instruction than teachers in the earliest grades. Specific ways in which teachers included information regarding the flood into their curriculum included discussion, reading stories, drawing pictures, and writing essays and books on topics which related to floods . It is important to note that these post disaster interventions were unplanned; individual classroom teachers made decisions about if and how they would make alterations in their curriculum in the wake of the disaster the previous year. School districts may find it advantage to us to develop contingency plans in the event that a disaster or another significantly disruptive event does occur. We also recommend that school districts more ca r e fully document post-disaster educational experiences of their students within and outside of the school district, in order to learn more about what types of academic interventions are helpful to students after the occurrence of disaster.
Peptide-Based Drugs: Development and Therapeutic Applications
Authors: Kanojia Akanksha , Singh Shekhar , Rai Vishal , Yadav Ajay 
Published: September 2024

Current advances in knowledge about peptides as drugs are of great significance; They have planning potentialities in different sections of medicinal practice. This review will summarize the progress in the synthesis and the biological activities of the peptide-based drug, along with some of the uses. We start with the historical aspect and key points in the development of the corresponding field. In general, the development part describes the approaches of peptides synthesis, design strategies, screening methods, and optimization for stability and bioavailability. We then describe the action of such mechanisms as with respect to receptors, enzymes, and peptides that can penetrate cells. It has also expanded the assessment of the description of peptide drugs in the treatment of cancer, cardiovascular diseases, metabolic diseases, neurological diseases, infectious diseases, and immunotherapy. We cover both the problems in the formation of peptide drugs like stability, delivery, and regulatory issues and the opportunities like nanotechnology, bioprinting, and CRISPR. Last, we discuss the outlook of the peptide-based therapeutics and review features, which are promising for the development of new trends and perspectives of application. The present review is intended to give an up-to-date and easy to grasp information regarding the status and perspectives of peptide-associated medicines in contemporary pharmacology.
Hair treatment products containing pigeon pea oil as chemical properties and anti-oxidant activity
Authors: Rattanabun Warongporn , Keawbankrud Wannisa , Pimpila Supranee , Roekudomsak Kulaporn , Phocharoen Chokchai , Suthiporn Petch , Nantakarat Surawit 
Published: September 2024

The comparing small type (T9) and big type (ICP 7035), which were extracted by hexane maceration, this study looks at the properties of pigeon pea oil in hair treatment products. It finds that the percentage yield of big seed (ICP 7035) oil is higher than that of small seed (T9) oil, at 9.64 ± 0.10 and 9.32 ± 0.08, respectively. A study on the chemical properties of the oil revealed values for saponification, acidity, iodine, and peroxide. In all trials, T9 outperformed ICP 7035 in terms of test results, demonstrating the presence of fatty acids in the molecular components of triglycerides. Compared to ICP 7035, T9 had a lower molecule weight and a lower saturation level, making it less susceptible to oxidative lipid disorder and the tendency to deplete oil. The flavonoid content of T9 is higher than that of ICP 7035, equal to 27.76 ± 0.65 mg GAE g-1 extract and 25.90 ± 0.69 mg GAE g-1 extract, respectively. The flavonoid content of T9 is higher than that of ICP 7035, equal to 20.67 ± 0.58 mg QE g-1 extract and 18.76 ± 0.65 mg QE g-1 extract, respectively. The DPPH test showed that T9 was a stronger antioxidant than ICP 7035, with amounts of 0.26 ± 0.04 mg g-1 of extract and 0.35 ± 0.05 mg g-1, respectively. The development of hair care products revealed that a mixture containing the optimal dosage of T9 effectively ensured smooth hair lines and prevented microorganism contamination in all recipes.
GRAPHICAL ABSTRACT

HIGHLIGHTS

Pigeon Pea Oil in Hair Care Products

Comparison of T9 and ICP 7035 oil properties.
ICP 7035 yield was higher than T9 yield.
Chemical properties of oil included saponification, acidity, iodine, and peroxide.
T9 oil had better phenolics, flavonoids, and DPPH values than ICP 7035.
T9-rich mixtures in hair care products ensure smooth hair lines and prevent microorganism contamination.
Kajian Matematika Skema Tanda Tangan Rainbow Berbasis Multivariat
Authors: Arbi Nur'aini Labibah  , Sa’aadah Sajjana Carita  
Published: September 2024

Skema tanda tangan Rainbow merupakan skema tanda tangan berbasis multivariat yang pertama kali diperkenalkan oleh Jintai Ding dan Dieter Schmidt pada tahun 2005, serta berhasil mencapai ronde 3 pada proyek standardisasi kriptografi post quantum NIST. Skema ini menerapkan penggunaan multilayer untuk meningkatkan efisiensi dari skema tanda tangan Unbalanced Oil and Vinegar (UOV). Skema tanda tangan Rainbow yang diikutsertakan merupakan hasil modifikasi dengan penambahan vektor biner salt r yang bertujuan untuk memenuhi klaim keamanan EUF-CMA. Pada penelitian ini, penulis melakukan pengkajian terhadap dasar dan karakteristik, serta analisis dari klaim keamanan EUF-CMA yang dimiliki oleh skema modifikasi tanda tangan rainbow. Skema tanda tangan Rainbow terbukti memenuhi keamanan EUF-CMA dan karakteristik authentic, not reusable, unalterable, serta cannot be repudiated. Namun, skema ini tidak terjamin memenuhi karakteristik unforgeable dikarenakan key recovery attack yang dilakukan Ward Beullens pada tahun 2022.
POLA KONSUMSI MASYARAKAT BELARUS TERHADAP PERTUMBUHAN EKONOMI NEGARA KAWASAN EROPA TIMUR
Authors: Dewi Anita Puspa , Sari Yesi Avita 
Published: September 2024

AbstractThis research discusses the consumption patterns of the people of Belarus regarding the economic growth of countries in the Eastern European region. The aim of this research is to determine the level of consumption in Belarus regarding the economic growth of countries in the Eastern European region. This research method uses qualitative research with a literature review and search study approach through country micro-macro data, namely ciecdata. The research results show that Belarus is a country that has a strong plantation sector and was named by UNISCO as the lungs of the European continent because the forest area in Belarus is 40%. The superior plantation is potatoes and is able to be exported to two regional countries, namely Poland and Lithuania, with total exports of 6.3% in February 2023. The level of personal consumption in Belarus was reported in 2023 at 53.7%, an increase compared to the previous year. Meanwhile, public consumption was 14.5% in September 2022, down from the previous 19.8% in July 2022. Public consumption patterns are related to the staple food potato because it involves government spending which can affect the production, accessibility and consumption of certain staple foods in the country. Keywords: Belarus, Consumption Patterns, Economic Growth, Eastern Europe AbstrakPenelitian ini membahas tentang pola konsumsi masyarakat Belarus terhadap pertumbuhan ekonomi negara kawasan Eropa Timur. Tujuan dari penelitian ini adalah untuk mengetahui tingkat konsumsi negara Belarush terhadap pertumbuhan ekonomi negara kawasan Eropa Timur. Metode penelitian ini menggunakan penelitian kualitatif dengan pendekatan studi literatur review dan penelusuran melalui data mikro makro negara yaitu ciecdata. Hasil penelitian menunjukan bahwa Belarus merupakan negara yang memiliki sektor perkebunan yang kuat dan dinobatkan oleh UNISCO sebagai paru-paru benua Eropa dikarenakan luas wilayah hutan di Belarus sebesar 40%. Perkebunan yang unggul adalah kentang dan mampu di ekspor ke dua negara kawasan yaitu Polandia dan Lithuania dengan total ekspor sebesar 6.3 % pada Februari 2023. Untuk tingkat konsumsi pribadi Belarus dilaporkan pada tahun 2023 sebesar 53.7 % mengalami kenaikan di bandingkan tahun sebelumnya. Sedangkan konsumsi publik sebesar 14.5 % pada bulan September 2022 turun dibanding sebelumnya yaitu sebesar 19.8 % pada Juli 2022. Pola konsumsi publik memiliki hubungan dengan makanan pokok kentang karena melibatkan pengeluaran pemerintah dapat mempengaruhi produksi, aksesibilitas, dan konsumsi makanan pokok tertentu di negara Kata Kunci : Belarus, Pola Konsumsi, Pertumbuhan Eonomi, Eropa Timur
PERBANDINGAN WAKTU PEKERJAAN BEKISTING KONVENSIONAL DENGAN BEKISTING SISTEM PADA PEKERJAAN KOLOM PROYEK PEMBANGUNAN GEDUNG RUMAH SAKIT GRESIK SEHATI
Authors: Mohammad Rizky Fadillah Bagus Pratama Putra  , Safitri Fikca Ayuk , Rifqi Mirza Ghulam 
Published: September 2024

Pembangunan gedung merupakan indikator penting dalam mengukur kemajuan suatu daerah. Dalam proyek Pembangunan Gedung Rumah Sakit Gresik Sehati digunakan bekisting konvensional untuk memaksimalkan pemanfaatan sumber daya yang ada. Namun terjadi penundaan akibat kerusakan alat pancang yang mengakibatkan keterlambatan keseluruhan proyek. Untuk mengatasi masalah tersebut penulis melakukan perbandingan waktu bekisting konvensional dengan bekisting sistem pada pekerjaan kolom. Penelitian ini bertujuan untuk mengetahui hasil dari perbandingan waktu pekerjaan bekisting konvensional dengan bekisting sistem pada pekerjaan kolom proyek Pembangunan Gedung Rumah Sakit Gresik Sehati. Metode penelitian menggunakan pendekatan waktu. Dimulai dengan identifikasi masalah keterlambatan progres pekerjaan, diikuti studi literatur dan pengumpulan data seperti gambar kerja, rancangan anggaran biaya, jadwal tenaga kerja, koefisien tenaga kerja bekisting, serta kurva S. Analisis data meliputi perhitungan volume pekerjaan, waktu pekerjaan, dan produktivitas tenaga kerja serta perbandingan waktu pekerjaan kedua bekisting. Kemudian dilanjutkan pembahasan hasil, serta penarikan kesimpulan dan saran. Hasil penelitian menunjukkan bahwa waktu pekerjaan kolom pada lantai 1 (pembesian, pemasangan bekisting, pengecoran, dan pembongkaran) menggunakan bekisting konvensional adalah 13 hari, sedangkan waktu pekerjaan kolom pada lantai 1 (pembesian, pemasangan bekisting, pengecoran, dan pembongkaran) menggunakan bekisting sistem adalah 8 hari. Perbandingan waktu pekerjaan pada kolom lantai 1 menggunakan bekisting konvensional dengan bekisting sistem adalah sebesar 1,625, menunjukkan bahwa bekisting sistem memiliki waktu yang lebih cepat dan produktivitas yang lebih besar daripada bekisting konvensional.
Analisis Strategi Pemasaran dan Komunikasi Dalam Meningkatkan Daya Beli (Studi Kasus Pada Kedai Kopi Sanawa)
Authors: Ilham Ilham , Muhajirin Muhajirin , Purnama Ita 
Published: September 2024

Penelitian ini bertujuan untuk menganalisis strategi pemasaran dan komunikasi yang diterapkan oleh Kedai Kopi Sanawa dalam upaya meningkatkan daya beli konsumen. Metode yang digunakan dalam penelitian ini adalah pendekatan kuantitatif dengan teknik pengumpulan data melalui kuesioner, wawancara mendalam, observasi, dan studi dokumentasi. Data dianalisis dengan statistik inferensial. Hasil penelitian menunjukkan bahwa Kedai Kopi Sanawa menerapkan berbagai strategi pemasaran, termasuk penggunaan media sosial, promosi diskon, dan kolaborasi dengan influencer lokal untuk menarik perhatian konsumen. Selain itu, komunikasi yang efektif dengan pelanggan melalui interaksi langsung dan feedback juga berperan penting dalam membangun loyalitas pelanggan. Penelitian ini menemukan bahwa kombinasi antara strategi pemasaran yang inovatif dan komunikasi yang baik dapat meningkatkan daya beli konsumen, yang tercermin dari peningkatan jumlah pengunjung dan penjualan. Rekomendasi untuk Kedai Kopi Sanawa adalah untuk terus mengembangkan strategi pemasaran yang adaptif dan memperkuat komunikasi dengan pelanggan guna mempertahankan dan meningkatkan daya beli di masa mendatang.
Meningkatkan Kemampuan Mengenal Kosa Kata Bahasa Arab Anggota Tubuh melalui Metode Bernyanyi Lagu Gubahan di Kelompok A1 di PPIT Lukmanul Hakim Gorontalo
Authors: Pakaya Widya wati 
Published: September 2024

PPIT Lukmanul Hakim merupakan salah satu PAUD berbasis ke Islaman. Aktivitas pembelajarannya mencakup hafalan Al-Quran, dengan demikian peserta didik perlu memahami kajian dalam surat-surat Al-Quran yang dihafal. Namun observasi awal menunjukkan rendahnya pengenalan kosa kata arab yaitu 52,17% terutama pada pengenalan kosa kata anggota tubuh. Tujuan penelitian ini untuk meningkatkan kemampuan mengenal kosa kata bahasa Arab anggota tubuh, dengan menggunakan metode bernyanyi lagu gubahan pada anak usia dini kelompok A1 di sekolah PPAUD IT Lukmanul Hakim Gorontalo. Metode penelitian yang digunakan adalah model Penelitian Tindakan Kelas (PTK) Kemmis Mc Taggart. Penelitian dilaksanakan dalam dua siklus, tiap siklus terdiri atas perencanaan, pelaksanaan, observasi dan refleksi. Subjek penelitian ini dilakukan pada anak kelompok A1 berusia 4 sampai 5 tahun di sekolah PPAUD IT Lukmanul Hakim Gorontalo yang berjumlah 23 siswa yang terdiri dari 10 laki-laki dan 13 perempuan. Pengumpulan data dalam penelitian ini dilakukan dengan mix method yaitu dengan pendekatan kualitatif dan kuantitatif. Hasil yang diperoleh dari penelitian ini terjadi peningkatan kemampuan mengenal kosa kata bahasa Arab anggota tubuh yaitu dari jumlah presentase obsevasi awal 52,17%, meningkat pada pelaksanaan siklus I menjadi 65%. Setelah dilakukan refleksi, dilanjutkan pada siklus II dengan presentase 90,86%. Maka dengan ini kemampuan mengenal kosa kata bahasa Arab anggota tubuh dapat meningkat dan dikatakan mampu melalui metode bernyanyi lagu gubahan di kelompok A1 PPAUD IT Lukmanul Hakim Gorontalo.