bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Final 30 Days of Life
Authors: Merchant Shaila J. , Lajkosz Katherine , Brogly Susan B. , Booth Christopher M. , Nanji Sulaiman , Patel Sunil V. , Baxter Nancy N. 
Published: November 2017

Background: Studies have reported overly aggressive end-of-life care (EOLC) in many cancers. We investigate trends in, and factors associated with, aggressive EOLC among patients who died of gastrointestinal (GI) cancers in Ontario, Canada. Methods: All patients with primary cause of death from esophageal, gastric, colon, and anorectal cancer from January 2003 to December 2013 were identified through the Ontario Cancer Registry, and information was collected from linked databases. Outcomes representing aggressive EOLC were assessed: administration of chemotherapy, any emergency department (ED) visits, hospital admissions, intensive care unit (ICU) admissions (all within 30 days of death), death in hospital and in ICU, and a composite outcome representing any aggressive EOLC. Temporal trends were analyzed using the Cochran-Armitage test. Results: There were 34 630 patients in the cohort: 43% colon, 26% anorectal, 19% gastric, and 12% esophageal cancers. Aggressive EOLC was delivered to 65%, with a significantly decreasing trend from 64.8% in 2003 to 62.5% in 2013 ( P = .001). Utilization of specific elements of aggressive EOLC included 8% chemotherapy, 46% ED visits, 49% hospital admissions, 6% ICU admissions, 45% death in hospital, and 5% death in ICU. Trends over the study period showed that ED visits (from 43% to 46.9%; P = .0001) and death in ICU (from 3.7% to 4.9%; P = .04) significantly increased; hospital admissions (from 48.9% to 47.8%; P = .02) and death in hospital (from 46.6% to 38.9%; P < .0001) significantly decreased. Conclusions: Two-thirds of patients with GI cancer had aggressive EOLC in the last 30 days of life.
Ubiquitin Fusion Degradation Protein 1 as a Blood Marker for the Early Diagnosis of Ischemic Stroke
Authors: Allard Laure , Turck Natacha , Burkhard Pierre R. , Walter Nadia , Rosell Anna , Gex-Fabry Marianne , Hochstrasser Denis F. , Montaner Joan , Sanchez Jean-Charles 
Published: November 2017

Background Efficacy of thrombolysis in acute ischemic stroke is strongly related to physician's ability to make an accurate diagnosis and to intervene within 3–6 h after event onset. In this context, the discovery and validation of very early blood markers have recently become an urgent, yet unmet, goal of stroke research. Ubiquitin fusion degradation protein 1 is increased in human postmortem CSF, a model of global brain insult, suggesting that its measurement in blood may prove useful as a biomarker of stroke. Methods Enzyme-linked immunosorbent assay (ELISA) was used to measure UFD1 in plasma and sera in three independent cohorts, European (Swiss and Spanish) and North-American retrospective analysis encompassing a total of 123 consecutive stroke and 90 control subjects. Results Highly significant increase of ubiquitin fusion degradation protein 1 (UFD1) was found in Swiss stroke patients with 71% sensitivity (95% CI, 52–85.8%), and 90% specificity (95% CI, 74.2–98%) ( N = 31, p < 0.0001). Significantly elevated concentration of this marker was then validated in Spanish ( N = 39, p < 0.0001, 95% sensitivity (95% CI, 82.7– 99.4%)), 76% specificity (95% CI, 56.5–89.7%)) and North-American stroke patients ( N = 53, 62% sensitivity (95% CI, 47.9–75.2%), 90% specificity (95% CI, 73.5–97.9%), p < 0.0001). Its concentration was increased within 3 h of stroke onset, on both the Swiss ( p < 0.0001) and Spanish ( p = 0.0004) cohorts. Conclusions UFD1 emerges as a reliable plasma biomarker for the early diagnosis of stroke, and in the future, might be used in conjunction with clinical assessments, neuroimaging and other blood markers.
The aspirin in reducing events in the elderly trial: Statistical analysis plan
Authors: Wolfe Rory , Murray Anne M , Woods Robyn L , Kirpach Brenda , Gilbertson David , Shah Raj C , Nelson Mark R , Reid Christopher M , Ernst Michael E , Lockery Jessica , Donnan Geoffrey A , Williamson Jeff , McNeil John J 
Published: November 2017

Rationale Aspirin has positive and negative effects on a number of age-related chronic conditions and there is uncertainty regarding its role in primary prevention in people aged 70 years and over. Aims To assess whether daily active treatment of 100 mg enteric-coated aspirin will extend the duration of disability-free life in healthy older participants. Design A double-blind, randomized, placebo-controlled primary prevention trial undertaken in Australia and the United States with careful adjudication of endpoints including stroke. Study outcome In Australia 16,703 individuals were recruited through general practices across five states and territories, and in the United States, 2411 participants were recruited through 34 clinical sites across the country. Follow-up of participants will finish at the end of 2017 with average follow-up exceeding 4.25 years per person. Discussion The statistical analysis plan for ASPREE, finalized after closure of recruitment but before the end of patient follow-up, outlines the primary analyses and a range of subgroup and sensitivity analyses. (International Standard Randomized Controlled Trial Number Register ISRCTN83772183 and clinicaltrials.gov Number NCT01038583)
Incidence, Etiology, and Outcomes of Altered Mental Status in the Perioperative Setting of Liver Transplantation
Authors: Lening Christopher , Agopian Vatche G. , Busuttil Ronald W. , Liebeskind David S. 
Published: November 2017

Background: We examined neurologic consultations for altered mental status in perioperative liver transplant patients to determine the overall incidence, to assess the presumed etiology and the data reviewed to determine that etiology, and to assess outcomes. Methods: Retrospective chart review conducted for all 728 adult patients receiving orthotopic liver transplantation (OLT) between January 01, 2010, to June 30, 2014, with identification of 218 receiving neurology consults between 30 days pre-OLT and 90 days post-OLT, with review of all records necessary to determine initial findings and follow-up examination. Results: Seventy-three consults for 69 patients were identified, with 27 felt to be altered since a procedure, 20 with sudden-onset altered mentation, and 26 with gradual or waxing–waning course. A single underlying etiology was identified in only 19 cases, with multiple factors involved in all others, with metabolic, toxic, infectious, and structural etiologies most often implicated. There was no statistically significant difference in outcome for those with altered mental status consults versus the total OLT population, though the sudden-onset presentation group did show significantly increased mortality rates. Conclusions: This systematic study illustrates the variety of potential causes of altered mentation within the perioperative setting of liver transplantation. Workup including neuroimaging (preferably magnetic resonance imaging), infectious cultures, and expanded metabolic laboratory tests should be undertaken.
Redirecting T cells to hematological malignancies with bispecific antibodies
Authors: Velasquez Mireya Paulina , Bonifant Challice L. , Gottschalk Stephen 
Published: November 2017

Abstract
There is a need to improve outcomes for patients with recurrent and/or refractory hematological malignancies. Immunotherapy holds the promise to meet this need, because it does not rely on the cytotoxic mechanism of conventional therapies. Among different forms of immunotherapy, redirecting T cells to hematological malignancies with bispecific antibodies (BsAbs) is an attractive strategy. BsAbs are an “off-the-shelf” product that is easily scalable in contrast to adoptive T-cell therapies. Among these, the bispecific T-cell engager blinatumomab has emerged as the most successful BsAb to date. It consists of 2 single-chain variable fragments specific for CD19 present on B-cell malignancies and CD3 expressed on almost all T cells. Blinatumomab has shown potent antitumor activity as a single agent, particularly for acute lymphoblastic leukemia, resulting in its US Food and Drug Administration approval. However, although successful in inducing remissions, these are normally short-lived, with median response durations of <1 year. Nevertheless, the success of blinatumomab has reinvigorated the BsAb field, which is bustling with preclinical and clinical studies for not only B-cell–derived lymphoblastic leukemia and lymphoma but also acute myeloid leukemia and multiple myeloma. Here, we will review the successes and challenges of T-cell–targeted BsAbs for the immunotherapy of hematological malignancies with special focus on conducted clinical studies and strategies to improve their efficacy.
Circulating fibrocytes as biomarkers of impaired lung function in adults with sickle cell disease
Authors: Mehrad Borna , Burdick Marie D. , Wandersee Nancy J. , Shahir Kaushik S. , Zhang Liyun , Simpson Pippa M. , Strieter Robert M. , Field Joshua J. 
Published: November 2017

Key Points
Fibrocytes are progenitor cells that home to injured organs and contribute to fibrosis. Levels of circulating fibrocytes are associated with pulmonary dysfunction in adults with SCD.
Proangiogenic alginate-g-pyrrole hydrogel with decoupled control of mechanical rigidity and electrically conductivity
Authors: DeVolder Ross J. , Seo Yongbeom , Kong Hyunjoon 
Published: November 2017

Abstract

Background
An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing elastic modulus of the hydrogels because of decreased transport of ions through a polymeric cross-linked mesh.

Method
This study hypothesized that the inverse dependency between electrical conductivity and elastic modulus would be made through the cross-linking of conductive monomer-units conjugated to a hydrophilic polymeric backbone. This hypothesis was examined through the cross-linking of pyrrole groups that were conjugated to an alginate backbone, termed alginate-g-pyrrole.

Results
Hydrogels with increased degrees of pyrrole substitution exhibited a simultaneous increase in the gels mechanical rigidity and electrical conductivity. The resulting hydrogel could control the adhesion and vascular endothelial growth factor secretion of cells via applied electrical stimulation.

Conclusions
This material design principle will be broadly useful to fabricating materials used for various actuation, cell culture, and biomedical applications.
Movement away from feeding site of the aphid Sitobion αvenαe (F.) (Hemiptera: Aphididae) when parasitized by Aphelinus αbdominαlis (Dalman) (Hymenoptera: Aphelinidae)
Authors: Lykouressis D.Ρ. , Emden Η.F. Υan 
Published: November 2017

The aphid Sitobion avenae (F.), parasitized by Aphelinus abdominalis (Dalman), tends to leave either the feeding sites gathering in particular parts of its host-plant or even the host-plant. This behavior partially explains the phenomenon of reduced parasitism contribution to the overall mortality in several aphid population studies as interpreted by Hughes’ method.
Υellow sticky rectangle with ammonium acetate slow-release dispenser: an efficient long-lasting trap for Dacus oleae
Authors: Economopoulos Α.Ρ. , Stavropoulou-Delivoria A. 
Published: November 2017

The combination of a yellow color sticky rectangle with an ammonium acetate slow-release dispenser (YAA) was compared to a yellow sticky rectangle (Y) and to a McPhail glass trap with BuminalTM(MB), EntomozylTM(ME), or ammonium sulfate (MAS) odor lure in a 2% water solution, from the beginning of August till December in an olive grove. When total olive fruit fly, Dacus oleae (Gmelin) (Diptera: Tephritidae), captures were compared, no large differences were detected among YAA, MB and ME traps, while Y and MAS ones were found much inferior. When expressed as a ratio to YAA, total captures were: 1 (YAA), 0.95 (MB), 0.70 (ME), 0.33 (Y) and 0.08 (MAS). In the fall (high population density), both yellow traps showed very high catches, while McPhail odor traps had comparatively reduced effectiveness, apparently due to cool humid weather. The opposite was true in August-September (hot dry weather, low population density). McPhail traps were serviced every 5 days (summer) or 7 days (fall), while YAA and Y traps were replaced by new ones only once, at the beginning of October. The am­monium acetate dispenser could last much longer but traps had been covered by insects and debris.
Effects of a juνenoid on lipid metabolism and fatty acid composition during growth of Heliothis armigera
Authors: Mazomenos Β.Ε. 
Published: November 2017

The effect of the juvenoid ZR-619 (Zoecon Corp.) on lipid metabolism and fatty acid composition of last instar larvae, pupae and pharate adults of Heliothis armigera Hbn. (Lepidoptera, Noctuidae) were studied. Treatments at low doses with the juvenoid resulted in an increase of the body weight of larvae and affected the composition of lipids accumulated. In non-treated larvae neutral lipids represent 88.9% of the total lipids, while in treated larvae, the neutral lipids are present at a lower level (80.2%). Fatty acid composition in untreated larvae, pupae and pharate adults is characterized by large proportions of palmitic and oleic acids and higher proportions of linoleic acid than of linolenic acid. Alteration in fatty acid composition is observed in phospholipids of pupae and pharate adults, the proportions of palmitic and oleic acid being lower than in larvae. The juvenoid ZR-619 slightly affected the fatty acid composition of neutral lipids in treated larvae, while fatty acid composition of phospholipids was affected.
Tenuipalpid mites (Acari: Tenuipalpidae) of Olea europaea with a key to Brevipalpus from the genus Olea
Authors: Hatzinikolis Ε.Ν. 
Published: November 2017

This paper deals with the tenuipalpid mites which are associated with olive trees and an account is given of their distribution, hosts, and bio-ecology. A key is provided to the species of Brevipalpus occurring on the genus Olea.
Α revision of the genus Cenopalpus in Greece (Acari: Tenuipalpidae)
Authors: Hatzinikolis Ε.Ν. , Emmanouel N.G. 
Published: November 2017

The genus Cenopalpus from Greece is revised and a key to 17 species is provided, with illustrations of the nymphs. Of these species, C. bakeri Diizgiines, C. carpini (Livshitz and Mitrofanov) and C. pseudospinosus (Livshitz and Mitrofanov) are recorded for the first time from this country. A new species C. arbuti is described and illustrated. Information on the hosts, distribution data and economic importance is presented for each species. Some of the hosts and damage symptoms are recorded for the first time.
Flight of San Jose scale, Quadraspidiotus perniciosus males and time of crawler appearance in orchards of northern Greece
Authors: Kyparissoudas D.S. 
Published: November 2017

The seasonal flight of San Jose scale (SJS), Quadraspidiotus perniciosus Comstock, males was studied during 1984-1987 in peach and nectarine orchards, under two different climatic conditions in Central Macedonia (Northern Greece), using sex pheromone traps. In late-season regions there were three periods of male flight activity (May, July-August, September – October), while in early-season regions there was also a partial fourth one (mid April-May, mid June-July. August – mid September and late September – early November). In the latter regions these flights can be correlated with the appearance of the scale crawlers during three periods (late May – early July, mid July – August, September – October) and a partial fourth one (November) in milder years, as determined using the sticky-tape trap technique. Pheromone traps and sticky-tape traps can be used for the study of phenology of San Jose scale, under conditions prevailing in Northern Greece.
Physokermes hemicryphus (Dalman) a fir scale insect useful to apiculture in Greece
Authors: Santas L.A. 
Published: November 2017

Physokermes hemicryphus (Dalman) is an important honeydew producing scale insect useful to apiculture. It lives mainly on Abies cephalonica Loud. and to a lesser degree on Abies borisii regis Mattf. These fir trees exist in most fir forests of Greece. It has one generation per year. Overwintering takes place in the second instar nymph. The female overwinters under the bud scales of the forks of the fir host and the male on the needles. Adults appear in spring and crawlers in July. In August the population consists mainly of first instar nymphs. The second instar nymphs start to appear in August and by late October the whole population is at the second nymphal instar, which is the overwintering one. The insect occurs in the fir forests of Greece every year but its population level fluctuates, due to weather conditions and biological factors (parasites, predators). The coexistence on the same host plant of P. hemicryphus with the scale Eulecanium sericeum (Lindiger) and the aphid Milldams abietinus (Koch) prevents the visit of honeybees to fir trees. On the other hand it favours the augmentation of the P. hemicryphus population. Four parasites were found, from which the Encyrtidae Pseudorhopus testaceus (Razz.) and Microterus lunatus (Dalman), are recorded for the first time in Greek fauna.
Summerfruit tοrtriχ, Adoxophyes orana: life cycle, warning system and control
Authors: Charmillot P.-J. , Brunner J. F. 
Published: November 2017

The summerfruit tortrix, Adoxophyes orana F.v.R., is a pest which has recently adapted to the intensive culture of apple and pear. The larvae develop primarily on the young leaves and shoots and occasionally feed on the surface of the fruit. Under Swiss conditions there are two flights per year though there are three in Greece with the second and third overlapping. The diapausing larvae hibernate in the third stage (L3) and begin development again in the spring. There are three periods in which the larvae are active. The methods used to sample populations for making management decisions are: visual examination of flower clusters in spring, sex pheromone traps, and visual examination of shoots and fruit in summer. A model describing the life cycle as a function of temperature allows for the determination of the best time to sample damage and to apply treatments with regard to their particular mode of action. Some classical insecticides provide control curatively but efficiency is always reduced against older larvae. The best results are obtained at egg eclosion following the first flight. The insect growth regulator (IGR), fenoxycarb, is very effective when applied in the spring against the last stage larvae (Ls) of the overwintering generation. A specific virus also gives good control in the spring against overwintering larvae. The mating disruption technique and insect growth inhibitors (ICI), which prevent the formation of chitin, are currently being studied. For all the products used to control A. orana, the timing of the application is extremely important in order to obtain the best
Control of insect pests on fruit and field crops with hexaflumuron in North Greece
Authors: Komblas Κ. Ν. , Tsakonas P. , Lysandrou M. , Elia Τ. Κ 
Published: November 2017

Experiments with hexaflumuron have been made against pests on apples, pears, peaches, potatoes and maize. On apples a predefined spray program was used for the combined control of Cydia pomonella (L) (Lepidoptera: Tortricidae), Phyllonorycter blancardella. (Fabr.) (Lepidoptera: Gracillariidae), P. corylifoliella (Hbn) (Lepidoptera: Gracillariidae), Leucoptera scitella (Zell.) (Lepidoptera: Lyonetiidae) and Adoxophyes orana (F.v. Roslerstamm) (Lepidoptera: Tortricidae). Sprays started when C. pomonella adults appeared and were continued every 2, 3 and 4 weeks. Against Cacopsylla pyri L. (Homoptera: Psyllidae), Anarsia lineatella Zell. (Lepidoptera: Gelechiidae) and Grapholitha molesta (Busck) (Lepidoptera: Tortricidae), trials were made to define efficacy and timing, while trials on Leptinotarsa decendineata (Say) (Coleoptera: Chrysomelidae) and Sesamia nonagrioides Lef. (Lepidoptera: Noctuidae) were only for efficacy. Hexaflumuron promised to be an excellent insecticide since it was at least as good as organophosphate standards, amitraz and the benzoylphenyl ureas (BPU) tested. With fewer sprays it gave seasonal and combined control on apple pests. It is a new BPU insecticide with low mammalian toxicity and fits IPM programs, since its toxicity to predators and parasites is low. Hexaflumuron had no effect on adults of the predator Coccinella septempunctata L. (Coleoptera: Coccinelidae) in the potato trial. Sprays must start at the beginning of the oviposition of fruit damaging pests and at the egg or early larva-nymph stage of the foliage damaging pests. The spray must fully cover fruit and foliage.
Two new species of the genus Typhlodromus Scheuten (Acari: Phytoseiidae) from Greece
Authors: Papadoulis G.TH , Emmanouel N.G. 
Published: November 2017

Adult females and males of two new Phytoseiid species, Typhlodromus pentelicus and Typhlodromus phylaktioticus, are described and illustrated. The former species was found on the bark of various trees while the latter was collected from Clematis sp. and Eragaria sp. in Greece.
Α new species, Bryobia attica (Acari: Tetranychidae) from Greece
Authors: Hatzinikolis Ε.Ν. , Emmanouel N.G. 
Published: November 2017

The adult female and larva of Bryobia attics n. sp. are described and illustrated. It was collected from Olea europaea bark in Kessariani and Koropi regions of Attiki, Greece.
Flight of White Peach Scale, Pseudαulαcαspis pentαgonα, Males and Time of Crawler Appearance in Northern Greece
Authors: Kyparissoudas D.S. 
Published: November 2017

The seasonal Wight of white peach scale (WPS), Pseudaulacaspis pentagona Targioni-Tozzetti, males was studied during 1989, 1990 and 1991 in a peach orchard of Central Macedonia in Northern Greece by sex pheromone trapping. Three periods of male flight activity (mid-May to late June, mid-July to late August and early September to early November) were recorded annually. These flights correlated with three periods of crawler emergence (late June to early August, second ten days of August to third ten days of September, and mid-April to early May late May to early June of the next year). The first two periods of crawler activity came approximately 33 and 27 days after the beginning of the two first periods of male flight, respectively, while the crawlers corresponding to the third male flight emerged approximately 15 days after the deposition of the first spring eggs.
The Spatial Pattern of Aphis gossypii οn Cotton
Authors: Kapatos E. T. , Stratopoulou E.T. , Tsitsipis J.A. , Lycouresis D.P. , Alexandri M.P. 
Published: November 2017

The spatial distribution of Aphis gossypii (Glover) on cotton was studied by using Taylor’s power law, the negative binomial parameter k and the iδ-index of aggregation. Both k and iδ were related to density with curvilinear relationships and indicated that aggregation decreases as density increases up to densities of, approximately, two individuals per leaf. At the very high densities (more than three individuals per leaf) the calculated values of the two indices recognized a tendency for an increased aggregation again. A strong linear relationship between the log mean and the log variance of the population density was obtained confirming the wide applicability of Taylor’s power law. However, the established relationship (b=1.433) assumes, for the range of the observed densities, a continuous decrease in the degree of aggregation as density increases. It is suggested that the changes in the degree of aggregation throughout the season and in relation to density are related to natural mortality.