bluuebunny/crossref_metadata_2025_split huggingface dataset:
Search for new materials based on chitosan for the protection of cultural heritage
Authors: Ermolyuk Anna , Avdanina Darya , Khayrova Adelya , Lopatin Sergey , Shumikhin Kirill , Kolganova Tat’yana , Simonenko Nikolay , Lunkov Alexey , Varlamov Valery , Shitov Mikhail , Zhgun Alexander 
Published: September 2024

Abstract
Microorganisms are a significant cause of damage to cultural heritage, including paintings. Currently, the palette of antiseptics that are used in painting has narrowed considerably. This is due to the increased demands placed on such substances. It was shown that low molecular weight chitosan (LMWC) obtained from the king crab (Paralithodes camtschaticus) exhibits high activity against dominant fungi-destructors of paintings in the State Tretyakov Gallery. Nevertheless, the increasing market demand for chitosan has prompted the exploration of alternative sources. Insects, notably the bioconverter black soldier fly (Hermetia illucens), stand out as one of the most cultivated options. This study investigates the effectiveness of chitosan, isolated from H. illucens by a novel method developed by authors, in inhibiting fungi that damage tempera paintings. The activity of 33 and 39 kDa chitosans from H. illucens is comparable to the most active chitosans previously studied from P. camtschaticus. However, there are characteristic differences between these compounds, as shown by the results of FTIR spectroscopy, which may affect their consumer properties when used in paint materials. Our studies suggest that LMWC from H. illucens is a promising material that can expand the range of antiseptics used in painting.

Graphical Abstract
Fit models’ roles in identifying fit issues in the apparel technical design process and implications for improving 3D virtual fitting
Authors: Yang Yoon , Baytar Fatma 
Published: September 2024

AbstractFit sessions are essential in making well-fitted clothing. During these sessions, apparel fit is determined iteratively by a team of designers, technical designers, fit models, and merchandisers. With the advent of the digitalization of new product development processes in the fashion industry, fit sessions have been seen as a bottleneck for they are still held in person. However, the process is currently still irreplaceable, and what makes the feedback provided by fit models important is an area that has never been tapped. Therefore, the present study aimed to understand fit models’ role in fit sessions as well as how they assess the fit of garments and deliver their feedback. On-site observation during fit sessions and individual interviews with fit models were conducted. It was found that fit models gave comfort, fit, and tactile comments by testing garments while standing and moving between several postures. They had knowledge that overlapped with those of technical designers and designers and this empowerment enabled them to take part in the decision-making process in fit sessions. It also was found that fit models’ feedback on garments was essential as they were the first people to try on the garments and present the customers’ points of view.
Ultrasound-guided radial vein cannulation for general anesthesia in cases with difficult peripheral venous access: a report of two cases
Authors: Motoyama Hironori , Tokumine Joho , Saito Yukiko , Moriyama Kiyoshi , Yorozu Tomoko 
Published: September 2024

Abstract
Background
Despite advancements in ultrasonography, locating peripheral veins for catheter placement remains a challenge in patients with altered anatomy owing to multiple surgeries. Herein, we highlight the potential of using the radial vein as an alternative site for ultrasound-guided peripheral venous catheterization.

Case presentation
We present two cases of patients with extensive surgical histories, including multiple abdominal surgeries, leading to difficult peripheral venous access. Traditional sites for peripheral venous catheterization were unsuitable due to vein narrowing or lack of visibility. In both cases, ultrasonography helped identify the radial vein as the only viable site for catheter placement. The patients underwent successful ultrasonography-guided catheterization of the radial vein without complications, facilitating medical management, including anesthesia induction and intraoperative monitoring.

Conclusions
The radial vein is a feasible and safe alternative for ultrasound-guided peripheral venous access in patients where traditional venous access sites are compromised.
Addiction to ultra-processed foods as a mediator between psychological stress and emotional eating during the COVID-19 pandemic
Authors: Stariolo Jasmin B. , Lemos Thayane C. , Khandpur Neha , Pereira Mirtes G. , de Oliveira Leticia , Mocaiber Izabela , Ramos Taiane C. , David Isabel A. 
Published: September 2024

Abstract
Background
The coronavirus disease 2019 (COVID-19) pandemic induced psychological distress, which is linked to emotional eating and symptoms of addiction to ultra-processed foods (UPFs).

Objective
This study aimed to investigate whether symptoms of addiction to UPFs mediate the relationship between psychological stress due to the COVID-19 pandemic and emotional eating behaviour.

Methods
A cross-sectional online study was conducted from May to November 2021 among 368 undergraduate Brazilian students. The participants answered demographic questions and completed validated scales, including the Coronavirus Stress Measure, Modified Yale Food Addiction Scale 2.0 and Emotional Eating Questionnaire. Mediation analysis was employed to examine the hypothesised relationships.

Results
The results revealed a significant indirect effect, indicating that symptoms of food addiction mediated the association between perceived stress during the COVID-19 pandemic and emotional eating behaviour. Specifically, 61% of the influence of perceived stress on emotional eating during the pandemic was explained by symptoms of UPF addiction.

Conclusion
These findings suggest that addressing symptoms of UPF addiction could be pivotal in public health strategies aimed at promoting healthy eating habits among distressed undergraduate students in the post-COVID-19 era.
Immunohistochemical evaluation of CD34, CD117, and calretinin for diagnosis of hirschsprung’s disease
Authors: Ladan Amirhossein , Aslanabadi Saeed , Badebarin Davoud , Jamshidi Masoud , Farhadi Ebrahim , Hasanzadeh Nazila , Naghavi Malihe , Moharrami Yeganeh Pegah 
Published: September 2024

Abstract
Introduction
Hirschsprung’s disease (HD) is a neurogenic intestinal disorder attributed to incomplete neural crest cell migration during fetal intestinal development, leading to an aganglionic segment of the colon and functional obstruction. Associated malformations like intestinal atresia, hydronephrosis, and imperforate anus can accompany Hirschsprung’s disease. this study aims to evaluate the efficacy of Calretinin and Cajal cells (CD34 and CD117) immunohistochemical staining in improving HD diagnosis.

Methods
The study involved 70 pediatric patients suspected of Hirschsprung’s disease. Clinical, histopathological, and immunohistochemical analyses were conducted, focusing on calretinin, CD34, and CD117 markers to identify ganglion cells and Cajal cells. Data were statistically analyzed using SPSS software.

Results
In the examination of the samples, the calretinin marker exhibited a consistent accuracy of 100% in diagnosing Hirschsprung’s disease (with sensitivity and specificity both at 100%). Regarding the markers for Cajal cells in cases of Hirschsprung’s disease, an irregularity in the arrangement of Cajal cells was observed, which was absent in normal cases. These markers also demonstrated a specificity and sensitivity of 100% in diagnosing the disease.

Conclusion
Hirschsprung’s disease remains a complex condition with multifaceted pathophysiological mechanisms. Calretinin immunohistochemical staining offers enhanced diagnostic accuracy, while the debate surrounding ICC distribution underscores the need for advanced diagnostic techniques. Further research is warranted to unravel the intricacies of Hirschsprung’s disease and its associated complications.
The influence of fire mosaics on mammal occurrence in north-western Australia
Authors: Moore Harry A. , Gibson Lesley A. , Nimmo Dale G. 
Published: September 2024

Abstract
Background
Understanding the relationship between fire and species habitat preferences is critical in an era of rapid environmental change. In northern Australia, large, intense, and frequent fires are thought to be a primary cause of mammal population declines, particularly through their influence on habitat suitability. Here, we used a large species presence database in combination with satellite-derived fire history data to assess the influence of fire attributes, including burn extent, frequency, and pyrodiversity, on the likelihood of occurrence of eight mammal species in north-west Western Australia.

Results
The likelihood of occurrence declined for some species with an increasing proportion of recently burnt habitat and increased for most species with an increasing proportion of long unburnt habitat. The occurrence of six species was negatively correlated with increasing fire frequency, while the occurrence of four species was positively correlated with increasing pyrodiversity.

Conclusions
Our results indicate that fire likely plays an important role in influencing mammal occurrence in the Pilbara and support previous research indicating that frequent large-scale burns have a mostly negative impact on small to medium-sized mammals in northern Australia. To improve mammal habitat suitability, land managers should aim to reduce the extent of large late dry season burns and increase the availability of mature spinifex grasslands.
Platelet indices as a predictor in patients with aplastic anemia and immune thrombocytopenic purpura: a retrospective case–control study
Authors: Abdel Hi Mahynour Z. , Khaled Safaa A. A. , Mahran Dalia G , Aly Mai M. 
Published: September 2024

Abstract
Background and objectives
Platelet indices are widely available and relatively cheap platelet parameters. The critical objective of this study is to assess the reliability of platelet indices as biomarkers for diagnosis and prognosis in adult thrombocytopenic patients.

Methods
A retrospective case–control study, including 81 immune thrombocytopenia (ITP) cases, 50 aplastic anemia (AA) cases, and 150 participants as a control group. This study included patients admitted from 2016 to 2021 to the Clinical Hematology Unit, Department of Internal Medicine, University Hospital. The collected data included sociodemographic information, clinical data, laboratory data, and an assessment of the therapeutic response in the studied groups.

Results
For the diagnosis of adult thrombocytopenic patients, platelet distribution width (PDW) showed the best diagnostic accuracy (85% for ITP and 91.9% for AA) at cutoff points of 14.9% and 17.2%, respectively. This was followed by mean platelet volume (MPV) with diagnostic accuracies of 77% for ITP and 89.3% for AA at a cutoff point of 9.4 fl. Platelet large cell ratio (PLCR) demonstrated insignificant accuracy in diagnosing either ITP or AA.

Conclusion
Platelet indices can play a crucial influence in the diagnosis, not the prognosis, of adult thrombocytopenia.

Trial registration
NCT05116033. https://classic.clinicaltrials.gov/ct2/show/NCT05116033
Accuracy of convex probe EBUS-TBNA versus FDG-PET/CT imaging in diagnosis and mediastinal staging of lung cancer patients; an Egyptian Experience
Authors: Embaby Dalia Abd El Sattar El , Abdullah Fatema AlZahraa Abdellatif , Korraa Emad , Shalaby Heba , Ibrahim Eman Abdel-Salam , Emam Wael , Mohammad Rehab M. 
Published: September 2024

Abstract
Background
Appropriate staging of lung cancer is of paramount importance, as it customizes treatment and predicts prognosis. Both Fludeoxyglucose-18 (FDG) positron emission tomography (PET) combined with contrast computed tomography (CT) and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) are two widely used diagnostic modalities in the field of staging & diagnosis of lung malignancies, the former depends on image analysis while the later enables real-time sampling of lymph nodes under sonographic guidance.

Objective
To compare the diagnostic and staging accuracy of convex probe EBUS-TBNA versus FDG – PET/CT as two modalities in diagnosis & mediastinal staging of lung cancer patients.

Methods
This prospective, observational (daignostic accuracy) research was performed on 40 cases with lung malignancies. All cases were examined via FDG-PET/CT followed by convex probe EBUS-TBNA for diagnosis & staging of concurrent mediastinal lymphadenopathy (MLN).

Results
The diagnostic yield of EBUS-TBNA reached 92.5% (37/40) compared to 70% (28/40) for FDG-PET/CT. There was poor agreement between EBUS-TBNA & FDG-PET/CT regarding (MLN) staging (k = 0.043), in 16/40 patients (40%), EBUS MLN staging matched that of FDG-PET/CT, while in 24/40(60%) there were discrepancies between the two diagnostic modalities; 18/40(45%) were up-staged after EBUS while 6/40(15%) were down staged after EBUS. In addition, EBUS-TBNA confirmed occult mediastinal nodal involvement in 9/10 FDG-PET/CT negative scans (N0). The overall diagnostic accuracy of EBUS-TBNA was significantly greater than FDG-PET/CT in staging of lung cancer (97.37% & 70% respectively, p < 0.001).

Conclusion
EBUS-TBNA is a minimally invasive procedure that we currently recommend as a first choice for MLN staging.

Trial registration
ClinicalTrials.gov, NCT06479798. Registered 26 June 2024—Retrospectively registered, https://clinicaltrials.gov/study/NCT06479798.
Influence of the use of a tablet-based clinical decision support algorithm by general practitioners on the consultation process: the example of FeverTravelApp
Authors: Vibert Jonas , Bourquin Céline , De Santis Olga , Cobuccio Ludovico , D’Acremont Valérie 
Published: September 2024

Abstract
Background
Despite the proven positive effects of clinical decision support systems (CDSSs) on general practitioners’ (GPs’) performance and patient management, their adoption remains slow. Several factors have been proposed to explain GPs' reluctance to adopt these tools. This study hypothesizes that the influence of CDSSs on patient-physician interactions could be a determining factor. To explore this hypothesis, we utilized the FeverTravelApp, designed to assist GPs in managing patients presenting with fever after returning from the tropics. A case–control study was conducted, observing and analyzing fourteen consultations between seven physicians and three simulated patients. Each physician conducted consultations both with and without the FeverTravelApp. The consultations were video-recorded and analyzed using a custom analysis grid based on three existing tools. Simulated patients completed the Communication Assessment Tool (CAT) after each consultation, and each physician participated in a semistructured interview following the use of the app.

Results
The use of the FeverTravelApp influenced multiple aspects of the consultation, particularly communication. Both patient and GP speaking times decreased, while active silence (no one talking while the GP actively performed a task) increased. GPs focused more on the app, which reduced direct patient interaction. However, this influence seemed to bother GPs more than simulated patients, who rated their GPs equally whether the app was used or not. This could be because patients felt better understood when GPs asked fewer but more specific questions related to travel medicine, thus effectively addressing their concerns.

Conclusions
This study supports the hypothesis that CDSSs influence consultation dynamics, which may contribute to their slow adoption. It is essential to involve clinicians early in the development of CDSSs to adapt them to clinical workflows and ensure system interoperability. Additionally, tools that allow clinicians to follow the entire clinical reasoning process, such as decision trees, are needed. Further research is necessary to confirm these findings in real patient settings and to develop CDSSs that meet both patients’ and GPs’ expectations.
Air quality and mental illness: role of bioaerosols, causal mechanisms and research priorities
Authors: Bhui Kamaldeep , Ucci Marcella , Kumar Prashant , Jackson Simon K. , Whitby Corinne , Colbeck Ian , Pfrang Christian , Nasir Zaheer A. , Coulon Frederic 
Published: September 2024

Background
Poor air quality can both trigger and aggravate lung and heart conditions, as well as affecting child development. It can even lead to neurological and mental health problems. However, the precise mechanisms by which air pollution affect human health are not well understood.

Aims
To promote interdisciplinary dialogue and better research based on a critical summary of evidence on air quality and health, with an emphasis on mental health, and to do so with a special focus on bioaerosols as a common but neglected air constituent.

Method
A rapid narrative review and interdisciplinary expert consultation, as is recommended for a complex and rapidly changing field of research.

Results
The research methods used to assess exposures and outcomes vary across different fields of study, resulting in a disconnect in bioaerosol and health research. We make recommendations to enhance the evidence base by standardising measures of exposure to both particulate matter in general and bioaerosols specifically. We present methods for assessing mental health and ideal designs. There is less research on bioaerosols, and we provide specific ways of measuring exposure to these. We suggest research designs for investigating causal mechanisms as important intermediate steps before undertaking larger-scale and definitive studies.

Conclusions
We propose methods for exposure and outcome measurement, as well as optimal research designs to inform the development of standards for undertaking and reporting research and for future policy.
Efficacy and Safety of Targeted Therapy for Radioiodine-Refractory Differentiated Thyroid Cancer
Authors: Zhang Yuqing , Zhang Xiaoxin , Lin Lifan , Xing Mingzhao 
Published: September 2024

Abstract

Context
There has been considerable success in the development of drugs for targeted therapy of radioiodine-refractory differentiated thyroid cancer (RR-DTC) and to know the safety and efficacy of these drugs will help their appropriate application.

Objective
To evaluate the efficacy and safety of current targeted drug therapies for radioiodine-refractory differentiated thyroid cancer.

Methods
This was a meta-analysis of relevant randomized controlled trials (RCTs) and single-arm studies searched across PubMed, Embase, Cochranes, and Web of Sciences up to September 12, 2023. Stata15.0 software was used to assess overall survival (OS), progression-free survival (PFS), disease control rate (DCR), objective response rate (ORR), and adverse events. The Cochrane Bias Risk tool was used to assess literature quality and trial bias and RevMan 5.4 was used to generate a quality assessment map.

Results
A total of 8 RCTs and 17 single-arm studies with 3270 patients on 7 drugs—vandetanib, sorafenib, lenvatinib, cabozantinib, apatinib, donafenib, and anlotinib—were included. Targeted therapy with these drugs effectively prolonged PFS and OS in patients with RR-DTC with overall hazard ratios of 0.35 (95% CI 0.23-0.53, P &lt; .00001) and 0.53 (95% CI 0.32-0.86, P &lt; .00001), respectively. ORR and DCR were also prolonged, with overall risk ratios of 27.63 (95% CI 12.39-61.61, P &lt; .00001) and 1.66 (95% CI 1.48-1.86, P &lt; .00001), respectively. The subgroup analysis using effect size (ES) showed that apatinib had the best effect on ORR with an ES of 0.66 (95% CI 0.49-0.83, P &lt; .00001) and DCR with a ES of 0.95 (95% CI 0.91-1.00, P &lt; .00001). Common drug adverse events included hypertension, diarrhea, proteinuria, and fatigue.

Conclusion
The currently used targeted drug therapies for RR-DTC can significantly improve clinical outcomes, and the new drug apatinib demonstrates promise for potentially superior performance.
Low-Rank Robust Subspace Tensor Clustering for Metro Passenger Flow Modeling
Authors: Sergin Nurretin Dorukhan , Hu Jiuyun , Li Ziyue , Zhang Chen , Tsung Fugee , Yan Hao 
Published: September 2024

Tensor clustering has become an important topic, specifically in spatiotemporal modeling, because of its ability to cluster spatial modes (e.g., stations or road segments) and temporal modes (e.g., time of day or day of the week). Our motivating example is from subway passenger flow modeling, where similarities between stations are commonly found. However, the challenges lie in the innate high-dimensionality of tensors and also the potential existence of anomalies. This is because the three tasks, that is, dimension reduction, clustering, and anomaly decomposition, are intercorrelated with each other, and treating them in a separate manner will render a suboptimal performance. Thus, in this work, we design a tensor-based subspace clustering and anomaly decomposition technique for simultaneous outlier-robust dimension reduction and clustering for high-dimensional tensors. To achieve this, a novel low-rank robust subspace clustering decomposition model is proposed by combining Tucker decomposition, sparse anomaly decomposition, and subspace clustering. An effective algorithm based on Block Coordinate Descent is proposed to update the parameters. Prudent experiments prove the effectiveness of the proposed framework via the simulation study, with a gain of +25% clustering accuracy over benchmark methods in a hard case. The interrelations of the three tasks are also analyzed via ablation studies, validating the interrelation assumption. Moreover, a case study in station clustering based on real passenger flow data is conducted, with quite valuable insights discovered. History: Bianca Maria Colosimo served as the senior editor for this article. Funding: H. Yan is partially funded by DOE [DE-EE0009354] and NSF [CMMI 2316654]. F. Tsung is partially funded with the RGC [GRF 16201718 and 16216119]. The authors appreciate the help from the Hong Kong MTR Co. research, marketing, and customer service teams. Data Ethics & Reproducibility Note: The code capsule is available on Code Ocean at https://codeocean.com/capsule/6536164/tree and in the e-Companion to this article (available at https://doi.org/10.1287/ijds.2022.0028 ).