bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic correlations among psychiatric and immune-related phenotypes based on genome-wide association data
Authors: Tylee Daniel S. , Sun Jiayin , Hess Jonathan L. , Tahir Muhammad A. , Sharma Esha , Malik Rainer , Worrall Bradford B. , Levine Andrew J. , Martinson Jeremy J. , Nejentsev Sergey , Speed Doug , Fischer Annegret , Mick Eric , Walker Brian R. , Crawford Andrew , Grant Struan F.A. , Polychronakos Constantin , Bradfield Jonathan P. , Sleiman Patrick M. A. , Hakonarson Hakon , Ellinghaus Eva , Elder James T. , Tsoi Lam C. , Trembath Richard C. , Barker Jonathan N. , Franke Andre , Dehghan Abbas ,   The 23andMe Research Team,   The Inflammation Working Group of the CHARGE Consortium, The METASTROKE Consortium of the International Stroke Genetics Consortium, The Netherlands Twin Registry, The neuroCHARGE Working Group, The Eating Disorders Working Groups of the Psychiatric Genomics Consortium, The Obsessive Compulsive Disorder and Tourette Syndrome Working Group, Faraone Stephen V. , Glatt Stephen J. 
Published: August 2016

AbstractIndividuals with psychiatric disorders have elevated rates of autoimmune comorbidity and altered immune signaling. It is unclear whether these altered immunological states have a shared genetic basis with those psychiatric disorders. The present study sought to use existing summary-level data from previous genome-wide association studies (GWASs) to determine if commonly varying single nucleotide polymorphisms (SNPs) are shared between psychiatric and immune-related phenotypes. We estimated heritability and examined pair-wise genetic correlations using the linkage disequilibrium score regression (LDSC) and heritability estimation from summary statistics (HESS) methods. Using LDSC, we observed significant genetic correlations between immune-related disorders and several psychiatric disorders, including anorexia nervosa, attention deficit-hyperactivity disorder, bipolar disorder, major depression, obsessive compulsive disorder, schizophrenia, smoking behavior, and Tourette syndrome. Loci significantly mediating genetic correlations were identified for schizophrenia when analytically paired with Crohn’s disease, primary biliary cirrhosis, systemic lupus erythematosus, and ulcerative colitis. We report significantly correlated loci and highlight those containing genome-wide associations and candidate genes for respective disorders. We also used the LDSC method to characterize genetic correlations amongst the immune-related phenotypes. We discuss our findings in the context of relevant genetic and epidemiological literature, as well as the limitations and caveats of the study.
Differential leadership, team conflict and new product development performance
Authors: Zhou Jianming , Liu Shuo , Zhang Xinsheng , Chen Ming 
Published: August 2016

PurposeThe purpose of this paper is to investigate the impact of native Chinese R&D team directors’ differential leadership on team performance, so as to understand whether and how the directors’ differential leadership impacts team conflict, whether and how team conflict impacts new product development performance of the R&D team and whether team conflict plays full mediation on the relationship between directors’ differential leadership and new product development performance.Design/methodology/approachA literature review on differential leadership and team conflict provided the model and hypothesis. Two-wave data collected from 103 directors and 344 subordinates from 103 R&D teams of high-tech enterprises from China’s Pearl River Delta Area were used as empirical study samples. Hierarchical multiple regression analysis was conducted to test the model and hypothesis.FindingsFirst, the team director’s differential leadership would cause significant team relationship conflict and team task conflict in the R&D team. Second, team relationship conflict and team task conflict would produce significantly bad new product development performance in the R&D team. Third, team relationship conflict would significantly mediate the relationship between the team director’s differential leadership and the team’s new product development performance.Research limitations/implicationsTo yield broader conclusions and to show to that the results can be replicated in other areas or in other types of organizations, further empirical research should expand the sampling by choosing high-tech enterprises from Beijing and Shanghai that have strong innovative abilities. Moreover, to extend the differential leadership theory, few more related variables of consequences, such as team communication, team cooperation and team knowledge share, should be included in future studies.Practical implicationsIn general, the native Chinese R&D department director needs to try their best to avoid the use of differential leadership style. In addition, reasonable incentive measures, promotion mechanisms and fair team work culture are needed so as to reduce the negative impact from the director’s differential leadership.Originality/valueThe paper is original in its investigation on how Chinese indigenous organizational factor – differential leadership – influences the R&D team’s conflict and new product development performance, and provides theoretical contribution and managerial implications for the R&D team management.
Interactive gaps and cause-effect-outcomes in processes and interfaces of teleological service encounters
Authors: Svensson Göran , Padin Carmen 
Published: August 2016

Purpose
The study aims to describe the interactive gaps between service receiver learning curves and service provider adaptive curves, as well as the cause-effect-outcome in processes and interfaces of service encounters, through the perspective of teleological actions.

Design/methodology/approach
This paper includes a qualitative study based on non-probability sampling of informants (air passengers).

Findings
The empirical findings indicate interactive gaps in teleological service encounters and a cause-effect-outcome sequence in the associated processes and interfaces.

Research limitations/implications
The study provides knowledge on how to manage the interactive interface between a service provider and a service receiver and a foundation for enhancing complaint handling in service encounters after critical incidents have occurred.

Practical implications
Service providers need to balance their teleological actions in relation to the service receivers’ teleological actions when critical incidents occur.

Originality/value
The paper takes into account service receiver teleological learning curves in relation to service provider teleological adaptive curves in an interactive transformative service encounter (TSE)-model that provides multiple opportunities for further research.
Pedagogical reforms within a centralised-decentralised system
Authors: Toh Yancy , Hung Wei Loong David , Chua Paul Meng-Huat , He Sujin , Jamaludin Azilawati 
Published: August 2016

Purpose
The purpose of this paper is to illustrate the dialectical interplay between centralisation and decentralisation forces so as to understand how schools leverage on its autonomous pedagogical space, influence the diffusion of innovations in the educational landscape of Singapore and how a centralised-decentralised system supports (or impedes) pedagogical reform for twenty-first century learning.

Design/methodology/approach
The paper first outlines the evolutionary stance of Singapore’s decentralisation from its past to present trajectories, thus providing a broader social-historical interpretation to its tight-loose-tight coupling of the education system; followed by situating the context of reform within the national narrative of Ministry of Education’s (MOE) twenty-first century competencies framework. The authors examine how school autonomy should be accompanied by systemic enabling mechanisms, through two case illustrations of whole-school reforms.

Findings
There are four carryover effects that the authors have observed: structural, socio-cultural, economic and epistemic. Middle managers from the two schools act as a pedagogical, socio-technological and financial broker outside the formal collaborative structures organised by the MOE. Such a “middle-out” approach, complemented by centralised mechanisms for “coeval sensing mechanism”, has resulted in boundary-spanning linkages and multiplier effects in terms of knowledge spillovers.

Research limitations/implications
Socio-cultural context matters; and what constitutes as co-learning between policymakers and practitioners in Singapore may be construed as policing that stifles innovations in other contexts.

Originality/value
In addition to the conceptualisation of how school autonomy may lead to school-based innovations, the paper provided some preliminary empirical evidence of how the co-production of knowledge has been engendered within, across and beyond individual Singapore schools through the mechanism of innovation diffusion. The unit of analysis is innovation ecosystem.
Climbing down the steps from the ivory tower: how UK academics and criminal justice practitioners need to work together on alcohol studies
Authors: Newbury-Birch Dorothy , McGeechan Grant J. , Holloway Aisha 
Published: August 2016

Purpose
Evidence in the UK tells us that risky drinking is high amongst those in contact with the criminal justice system. The purpose of this paper is to explore the reasons why carrying out research around risky drinking in this setting is so difficult.

Design/methodology/approach
A commentary on the issues of carrying out research in the criminal justice setting.

Findings
There are issues of carrying out research in the criminal justice setting. The authors argue, that as academics we can be more proactive in working with practitioners in the design and carrying out of studies. By examining what the primary outcome of interest is to those that work in the field rather than what funding agencies tell us academics must use, academics may engage in a more co-productive way that enables everyone to achieve what they need. Moreover more work is needed to show how this approach can be achieved both in the UK and internationally.

Originality/value
This editorial explores some of the difficulties of carrying out alcohol research in the criminal justice system and postulates ways that this could be made easier.
Corporate social responsibility: the case of the telecommunications sector
Authors: Sutherland Ewan 
Published: August 2016

PurposeThe paper aims to examine the reporting of corporate social responsibility (CSR) in the telecommunications sector and to consider how the obligations and regulations imposed on operators affect what is considered as CSR compared to other sectors.Design/methodology/approachThe paper provides a review of the academic literature on CSR, relating this to developments in the regulatory state and the adoption by governments and intergovernmental bodies of CSR instruments. Also, the paper conducts an analysis of coltan, greenhouse gas emissions and privacy as short case studies where CSR issues and regulations meet.FindingsMany activities that in other sectors would be considered CSR are required by licence or legislation, together with much more detailed scrutiny and reporting.Originality/valueThe paper provides a review of existing literature on CSR in telecommunications, related to theories about CSR and the regulatory state.
Use of AHP in decision-making for machine tool configurations
Authors: Farhan Uday Hameed , Tolouei-Rad Majid , Osseiran Adam 
Published: August 2016

Purpose
The purpose of this paper is to develop a model of analytic hierarchy process (AHP), a multiple criteria decision-making method, to assist selecting suitable machine configurations for special purpose machines (SPMs) from available alternatives.

Design/methodology/approach
The necessary criteria and sub-criteria were identified and used in the developed model. The assessment process was carried out by constructing the hierarchy of four levels. Then, pairwise comparison matrices were created for each level to compute the weights for the alternatives. The model was programmed and implemented by software for practical use.

Findings
Different scenarios were obtained from the assessment process of the developed AHP model showing the influence of changing the relevant importance of the elements in the hierarchy on the selection of SPMs configurations. Selection of the suitable scenario was also affected by some factors of manufacturing preferences and industry recommendations such as cost and production rate.

Originality/value
This is a new application of AHP method which assists decision makers to select suitable configurations for SPMs, and reduce the time required for designing SPMs.
Examining the link between service modularity and firm performance
Authors: Cheng Colin C.J. , Shiu Eric 
Published: August 2016

PurposeWhile service scholars have generally supported the idea that service modularity enhances firm performance, the literature offers very little evidence of the actual process through which service modularity continuously contributes to firm performance. The purpose of this paper is to examine the link from a capability perspective: service modularity capabilities-service modularity-new service advantage-firm performance, as well as the moderating role of radical innovation capability in the effect of service modularity on new service advantage.Design/methodology/approachTo examine this link, data were collected from a cross-industry survey of 231 leading service firms. Structural equation modeling and hierarchical moderated regression analyses were employed to test the model.FindingsAnalyses reveal that new service advantage mediates the service modularity-firm performance relationship. Moreover, service modularity capabilities act in an important antecedent role to configure service modularity. Among the findings, it is worth emphasizing that radical innovation capability not only strengthens the positive effect of, but also alleviates the negative effect of, service modularity on new service advantage.Originality/valueThis study provides a more complete understanding of how service modularity enhances firm performance by discovering the hidden role of new service advantage that bridges service modularity and firm performance, clarifying the role of service modularity capabilities in configuring service modularity, and confirming the important role of radical innovation capability in sustaining the effectiveness of service modularity.
Prompting additional purchases while providing service: does it offend the customer?
Authors: Ku Hsuan-Hsuan , Huang Chih-Yun 
Published: August 2016

Purpose
The purpose of this paper is to investigate consumers’ responses to unsolicited cross-selling of supplementary paid-for services made during delivery of a core service, and the contextual and personal variables moderating those responses.

Design/methodology/approach
Three formal experiments test the effect on participants’ responses of the perceived relevance of the supplementary service to the core service, personal psychological reactance, in the case of a high-relevance supplementary service, and self-monitoring, in scenarios in which a low-relevance supplementary service is proposed either in public or privately.

Findings
The experiments found that participants’ satisfaction ratings were reduced in response to cross-selling of a supplementary service that was of low relevance to the core service, and that satisfaction ratings if it was perceived to be of high relevance compared were not reduced despite the unsolicited attempt at cross-selling. However, the non-negative response to a high-relevance offer was limited to participants with a lower tendency to reactance. Furthermore, a high predisposition to self-monitoring evoked more positive judgments if a low-relevance supplementary service was proposed in public rather than privately. That of low self-monitors was no different in either case.

Originality/value
This paper examines the trade-off faced by a service provider between customer satisfaction and extra revenue from supplementary services, and explores conditions under which a provider can propose unsolicited supplementary services without offending customers.
Methadone maintenance dose/weight ratio, long QTc, and EKG screening
Authors: Westermeyer Joseph , Adabag Selcuk , Anand Vidhu , Thuras Paul , Yoon Gihyun , Batres‐y‐Carr Tegan 
Published: August 2016

Background and ObjectivesElectrocardiogram (EKG) monitoring during methadone maintenance treatment (MMT) has been recommended to prevent potentially fatal prolonged computed QT intervals (QTc). However, risk indicators for obtaining EKGs do not exist. This study assessed 23 variables that might help identify prolonged QTc during MMT.MethodsEKGs concurrent with methadone serum levels were obtained from 69 veterans during a 5‐year study, encompassing 302.8 person‐years. Two cardiologists hand‐measured QT intervals, selecting each patient's longest QTc. QTc categories included: normal duration <440 ms; borderline duration of 440–469 ms; and abnormal duration ≥470 ms. QTc's were compared with seven methadone parameters and 16 bio‐psycho‐social variables using two QTc cut‐offs (440 and 470 ms).ResultsAmong the 69 patients, 19 had normal QTc's, 28 had borderline QTc's, and 22 had abnormal QTc's. Methadone dose/weight was moderately correlated with QTc, and independently associated with longer QTc at both 440 and 470 cut‐offs.Discussion and ConclusionDose/weight ≥.49 is useful for screening EKGs for QTc's ≥440 cut‐off. Dose/weight ≥.65 produces high‐yield abnormal QTc's ≥470 cut‐off.Scientific SignificanceMethadone dose/weight provides moderately reliable thresholds for making routine screening decisions and urgent clinical decisions to obtain an EKG for prolonged QTc. (Am J Addict 2016;25:499–507).
Direct Inhibitory Effects of Carbon Monoxide on Six Venoms Containing Fibrinogenolytic Metalloproteinases
Authors: Nielsen Vance G. , Losada Philip A. 
Published: August 2016

AbstractSince the introduction of antivenom administration over a century ago to treat venomous snake bite, it has been the most effective therapy for saving life and limb. However, this treatment is not always effective and not without potential life‐threatening side effects. We tested a new paradigm to abrogate the plasmatic anticoagulant effects of fibrinogenolytic snake venom metalloproteinases (SVMP) by inhibiting these Zn+2‐dependent enzymes directly with carbon monoxide (CO) exposure. Assessment of the fibrinogenolytic effects of venoms collected from the Arizona black rattlesnake, Northern Pacific rattlesnake, Western cottonmouth, Eastern cottonmouth, Broad‐banded copperhead and Southern copperhead on human plasmatic coagulation kinetics was performed with thrombelastography in vitro. Isolated exposure of all but one venom (Southern copperhead) to CO significantly decreased the ability of the venoms to compromise coagulation. These results demonstrated that direct inhibition of transition metal‐containing venom enzymes by yet to be elucidated mechanisms (e.g. CO, binding to Zn+2 or displacing Zn+2 from the catalytic site, CO binding to histidine residues) can in many instances significantly decrease fibrinogenolytic activity. This new paradigm of CO‐based inhibition of the anticoagulant effects of SVMP could potentially diminish haemostatic compromise in envenomed patients until antivenom can be administered.
Three‐dimensional cell culture model utilization in cancer stem cell research
Authors: Bielecka Zofia F. , Maliszewska‐Olejniczak Kamila , Safir Ilan J. , Szczylik Cezary , Czarnecka Anna M. 
Published: August 2016

ABSTRACTThree‐dimensional (3D) cell culture models are becoming increasingly popular in contemporary cancer research and drug resistance studies. Recently, scientists have begun incorporating cancer stem cells (CSCs) into 3D models and modifying culture components in order to mimic in vivo conditions better. Currently, the global cell culture market is primarily focused on either 3D cancer cell cultures or stem cell cultures, with less focus on CSCs. This is evident in the low product availability officially indicated for 3D CSC model research. This review discusses the currently available commercial products for CSC 3D culture model research. Additionally, we discuss different culture media and components that result in higher levels of stem cell subpopulations while better recreating the tumor microenvironment. In summary, although progress has been made applying 3D technology to CSC research, this technology could be further utilized and a greater number of 3D kits dedicated specifically to CSCs should be implemented.
Association between glycaemic control and common infections in people with Type 2 diabetes: a cohort study
Authors: Hine J. L. , de Lusignan S. , Burleigh D. , Pathirannehelage S. , McGovern A. , Gatenby P. , Jones S. , Jiang D. , Williams J. , Elliot A. J. , Smith G. E. , Brownrigg J. , Hinchliffe R. , Munro N. 
Published: August 2016

AbstractAimTo investigate the impact of glycaemic control on infection incidence in people with Type 2 diabetes.MethodsWe compared infection rates during 2014 in people with Type 2 diabetes and people without diabetes in a large primary care cohort in the UK (the Royal College of General Practitioners Research and Surveillance Centre database). We performed multilevel logistic regression to investigate the impact of Type 2 diabetes on presentation with infection, and the effect of glycaemic control on presentation with upper respiratory tract infections, bronchitis, influenza‐like illness, pneumonia, intestinal infectious diseases, herpes simplex, skin and soft tissue infections, urinary tract infections, and genital and perineal infections. People with Type 2 diabetes were stratified by good [HbA1c < 53 mmol/mol (< 7%)], moderate [HbA1c 53–69 mmol/mol (7–8.5%)] and poor [HbA1c > 69 mmol/mol (> 8.5%)] glycaemic control using their most recent HbA1c concentration. Infection incidence was adjusted for important sociodemographic factors and patient comorbidities.ResultsWe identified 34 278 people with Type 2 diabetes and 613 052 people without diabetes for comparison. The incidence of infections was higher in people with Type 2 diabetes for all infections except herpes simplex. Worsening glycaemic control was associated with increased incidence of bronchitis, pneumonia, skin and soft tissue infections, urinary tract infections, and genital and perineal infections, but not with upper respiratory tract infections, influenza‐like illness, intestinal infectious diseases or herpes simplex.ConclusionsAlmost all infections analysed were more common in people with Type 2 diabetes. Infections that are most commonly of bacterial, fungal or yeast origin were more frequent in people with worse glycaemic control.