bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Guide to Inpatient Cancer Rehabilitation: Focusing on Patient Selection and Evidence‐Based Outcomes
Authors: Fu Jack B. , Raj Vishwa S. , Guo Ying 
Published: September 2017

AbstractCancer inpatients commonly suffer from impairments that can prohibit safe discharge home from the acute care inpatient medical service and thus require transfer to a postacute inpatient rehabilitation facility. It has been demonstrated in multiple studies that cancer rehabilitation inpatients are able to make statistically significant functional improvements and at a similar pace as their noncancer counterparts. Medical fragility and reimbursement regulations are concerns that affect acceptance and triage of cancer rehabilitation inpatients. Strategies to rehabilitate these challenging patients include considering risk factors for medical complications, consult‐based inpatient rehabilitation, and improved communication and coordination with oncology teams.
The Underutilization of Rehabilitation to Treat Physical Impairments in Breast Cancer Survivors
Authors: Stubblefield Michael D. 
Published: September 2017

AbstractBreast cancer survivors can experience multiple neuromuscular, musculoskeletal, pain, and functional disorders as a result of their cancer and its treatment. Common disorders include shoulder dysfunction, postmastectomy syndrome, chemotherapy‐induced peripheral neuropathy, axillary cording, lymphedema, and a host of others. Cancer rehabilitation is a process that helps breast cancer and other survivors to obtain and maintain the highest possible physical, social, psychological, and vocational functioning within the limits created by cancer and its treatments. There are good data supporting the safety and efficacy of cancer rehabilitation in the treatment of many breast cancer−related impairments, including shoulder dysfunction and lymphedema, among others. Despite the goals and efficacy of cancer rehabilitation, there is a marked underuse of services. The reasons for this phenomenon are many, but broadly result from a lack of knowledge about cancer rehabilitation on the part of patients and referring clinicians, limited access to services, and suboptimal adherence. This article explores underutilization of cancer rehabilitation in breast cancer survivors and provides an opportunity to consider ways to improve this gap in care.
A Focused Review of Safety Considerations in Cancer Rehabilitation
Authors: Maltser Susan , Cristian Adrian , Silver Julie K. , Morris G. Stephen , Stout Nicole L. 
Published: September 2017

AbstractCancer and its treatments introduce various adverse effects that may affect survivors' physical, cognitive and psychological functioning. Frequently both tolerance to activity and exercise are affected as well. Rehabilitation providers should have substantive knowledge about the effect of cancer progression and common side effects associated with antineoplastic treatment to safely integrate rehabilitation interventions. Rehabilitation may mitigate loss of function and disability; however, these patients are among the most medically complex that providers treat. This report provides a focused review that synthesizes the current evidence regarding disease progression and oncology‐directed treatment side effects within the context of safety considerations for rehabilitation interventions throughout the continuum of cancer care. Descriptive information regarding the evidence for precautions and contraindications is provided so that rehabilitation providers can promote a safe plan of rehabilitation care. It is incumbent upon but also challenging for rehabilitation providers to stay up to date on the many advances in cancer treatment, and there are many gaps in the literature regarding safety issues. Although further research is needed to inform care, this review provides clinicians with a framework to assess patients with the goal of safely initiating rehabilitation interventions.
Quality improvement primer part 2: executing a quality improvement project in the emergency department
Authors: Chartier Lucas B. , Stang Antonia S. , Vaillancourt Samuel , Cheng Amy H. Y. 
Published: September 2017

ABSTRACTThe topics of quality improvement (QI) and patient safety have become important themes in health care in recent years, particularly in the emergency department setting, which is a frequent point of contact with the health care system for patients. In the first of three articles in this series meant as a QI primer for emergency medicine clinicians, we introduced the strategic planning required to develop an effective QI project using a fictional case study as an example. In this second article we continue with our example of improving time to antibiotics for patients with sepsis, and introduce the Model for Improvement. We will review what makes a good aim statement, the various categories of measures that can be tracked during a QI project, and the relative merits and challenges of potential change concepts and ideas. We will also present the Model for Improvement’s rapid-cycle change methodology, the Plan-Do-Study-Act (PDSA) cycle. The final article in this series will focus on the evaluation and sustainability of QI projects.
Elastohydrodynamic wake and wave resistance
Authors: Arutkin Maxence , Ledesma-Alonso René , Salez Thomas , Raphaël Élie 
Published: September 2017

The dynamics of a thin elastic sheet lubricated by a narrow layer of liquid is relevant to various situations and length scales. As a continuation of our previous work on viscous wakes (Ledesma-Alonsoet al.,J. Fluid Mech., vol. 792, 2016, pp. 829–849), we study theoretically the effects of an external pressure disturbance moving at constant speed along the surface of a thin lubricated elastic sheet. In the comoving frame, the imposed pressure field creates a stationary deformation of the free interface that spatially vanishes in the far-field region. The shape of the wake and the way it decays depend on the speed and size of the external disturbance, as well as the rheological properties of both the elastic and liquid layers. The wave resistance, namely the force that has to be externally furnished in order to maintain the wake, is analysed in detail.
Ethical and Legal Implications of the Methodological Crisis in Neuroimaging
Authors: KELLMEYER PHILIPP 
Published: September 2017

Abstract:Currently, many scientific fields such as psychology or biomedicine face a methodological crisis concerning the reproducibility, replicability, and validity of their research. In neuroimaging, similar methodological concerns have taken hold of the field, and researchers are working frantically toward finding solutions for the methodological problems specific to neuroimaging. This article examines some ethical and legal implications of this methodological crisis in neuroimaging. With respect to ethical challenges, the article discusses the impact of flawed methods in neuroimaging research in cognitive and clinical neuroscience, particularly with respect to faulty brain-based models of human cognition, behavior, and personality. Specifically examined is whether such faulty models, when they are applied to neurological or psychiatric diseases, could put patients at risk, and whether this places special obligations on researchers using neuroimaging. In the legal domain, the actual use of neuroimaging as evidence in United States courtrooms is surveyed, followed by an examination of ways that the methodological problems may create challenges for the criminal justice system. Finally, the article reviews and promotes some promising ideas and initiatives from within the neuroimaging community for addressing the methodological problems.
The Measurement of Variability and Change in Life	Satisfaction
Authors: Gnambs Timo , Buntins Katja 
Published: September 2017

Abstract. In many large-scale surveys, life satisfaction is measured with a single item. Little is known about how sensitive single-item instruments react to changes across time or in the face of critical life events. The present study draws on a Dutch sample of N = 4,034 participants who were administered three different single items and an established multi-item instrument at four annual surveys within 6 years. An indicator-specific latent state-trait growth model was employed to estimate the agreement in change coefficients for the different instruments. The results indicated that single items estimated a similar developmental decline in life satisfaction across the life course as multi-item scales, but they were less sensitive to the loss of paid work. Interindividual differences in intraindividual change were better captured with multiple items. Moreover, single items reflected occasion-specific variance to a larger degree than longer scales. In addition, occasion-specific effects were larger among younger respondents as compared to older age groups. Therefore, single items appear to represent valid measures for the estimation of the average change in life satisfaction within a sample. However, they might exhibit a low power to detect moderating influences on the estimated change trajectories and capture less trait variance than multi-item scales.
A Continuous-Time Mixture Latent-State-Trait Markov Model for	Experience Sampling Data
Authors: Crayen Claudia , Eid Michael , Lischetzke Tanja , Vermunt Jeroen K. 
Published: September 2017

Abstract. In psychological research, statistical models of latent state-trait (LST) theory are popular for the analysis of longitudinal data. We identify several limitations of available models when applied to intensive longitudinal data with categorical observed and latent variables and inter- and intraindividually varying time intervals. As an extension of available LST models for categorical data, we describe a general mixed continuous-time LST model that is suitable for intensive longitudinal data with unobserved heterogeneity and individually varying time intervals. This model is illustrated by an application to momentary mood data that were collected in an experience sampling study (N = 164). In addition, the results of a simulation study are reported that was conducted to find out (a) the minimal data requirements with respect to sample size and number of occasions, and (b) how strong the bias is if the continuous-time structure is ignored. The empirical application revealed two classes for which the transition pattern and effects of time-varying covariates differ. In the simulation study, only small differences between the continuous-time model and its discrete-time counterpart emerged. Sample sizes N = 100 and larger in combination with six or more occasions of measurement tended to produce reliable estimation results. Implications of the models for future research are discussed.
Cascading effects of thermally-induced anemone bleaching on associated anemonefish hormonal stress response and reproduction
Authors: Beldade Ricardo , Blandin Agathe , O’Donnell Rory , Mills Suzanne C. 
Published: September 2017

AbstractOrganisms can behaviorally, physiologically, and morphologically adjust to environmental variation via integrative hormonal mechanisms, ultimately allowing animals to cope with environmental change. The stress response to environmental and social changes commonly promotes survival at the expense of reproduction. However, despite climate change impacts on population declines and diversity loss, few studies have attributed hormonal stress responses, or their regulatory effects, to climate change in the wild. Here, we report hormonal and fitness responses of individual wild fish to a recent large-scale sea warming event that caused widespread bleaching on coral reefs. This 14-month monitoring study shows a strong correlation between anemone bleaching (zooxanthellae loss), anemonefish stress response, and reproductive hormones that decreased fecundity by 73%. These findings suggest that hormone stress responses play a crucial role in changes to population demography following climate change and plasticity in hormonal responsiveness may be a key mechanism enabling individual acclimation to climate change.
The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry
Authors: Vilhais-Neto Gonçalo C. , Fournier Marjorie , Plassat Jean-Luc , Sardiu Mihaela E. , Saraf Anita , Garnier Jean-Marie , Maruhashi Mitsuji , Florens Laurence , Washburn Michael P. , Pourquié Olivier 
Published: September 2017

AbstractBilateral symmetry is a striking feature of the vertebrate body plan organization. Vertebral precursors, called somites, provide one of the best illustrations of embryonic symmetry. Maintenance of somitogenesis symmetry requires retinoic acid (RA) and its coactivator Rere/Atrophin2. Here, using a proteomic approach we identify a protein complex, containing Wdr5, Hdac1, Hdac2 and Rere (named WHHERE), which regulates RA signaling and controls embryonic symmetry. We demonstrate that Wdr5, Hdac1, and Hdac2 are required for RA signaling in vitro and in vivo. Mouse mutants for Wdr5 and Hdac1 exhibit asymmetrical somite formation characteristic of RA-deficiency. We also identify the Rere-binding histone methyltransferase Ehmt2/G9a, as a RA coactivator controlling somite symmetry. Upon RA treatment, WHHERE and Ehmt2 become enriched at RA target genes to promote RNA polymerase II recruitment. Our work identifies a protein complex linking key epigenetic regulators acting in the molecular control of embryonic bilateral symmetry.
A general mechanism of ribosome dimerization revealed by single-particle cryo-electron microscopy
Authors: Franken Linda E. , Oostergetel Gert T. , Pijning Tjaard , Puri Pranav , Arkhipova Valentina , Boekema Egbert J. , Poolman Bert , Guskov Albert 
Published: September 2017

AbstractBacteria downregulate their ribosomal activity through dimerization of 70S ribosomes, yielding inactive 100S complexes. In Escherichia coli, dimerization is mediated by the hibernation promotion factor (HPF) and ribosome modulation factor. Here we report the cryo-electron microscopy study on 100S ribosomes from Lactococcus lactis and a dimerization mechanism involving a single protein: HPFlong. The N-terminal domain of HPFlong binds at the same site as HPF in Escherichia coli 100S ribosomes. Contrary to ribosome modulation factor, the C-terminal domain of HPFlong binds exactly at the dimer interface. Furthermore, ribosomes from Lactococcus lactis do not undergo conformational changes in the 30S head domains upon binding of HPFlong, and the Shine–Dalgarno sequence and mRNA entrance tunnel remain accessible. Ribosome activity is blocked by HPFlong due to the inhibition of mRNA recognition by the platform binding center. Phylogenetic analysis of HPF proteins suggests that HPFlong-mediated dimerization is a widespread mechanism of ribosome hibernation in bacteria.
MRAP2 regulates ghrelin receptor signaling and hunger sensing
Authors: Srisai Dollada , Yin Terry C. , Lee Abigail A. , Rouault Alix A. J. , Pearson Nicole A. , Grobe Justin L. , Sebag Julien A. 
Published: September 2017

AbstractGhrelin is the only known circulating orexigenic hormone. It is primarily secreted by the stomach and acts at its receptor, the growth hormone secretagogue receptor 1a (GHSR1a), in the hypothalamus to signal hunger and promote food intake. The melanocortin receptor accessory protein 2 (MRAP2) was previously shown to regulate energy homeostasis through the modulation of the activity of the melanocortin-4 receptor and prokineticin receptors. In this study we identify MRAP2 as a partner of ghrelin-GHSR1a signaling. We show that MRAP2 interacts with GHSR1a and potentiates ghrelin-stimulated signaling both in vitro and in vivo. We demonstrate that in the absence of MRAP2, fasting fails to activate agouti-related protein neurons. In addition, we show that the orexigenic effect of ghrelin is lost in mice lacking MRAP2. Our results suggest that MRAP2 is an important modulator of the energy homeostasis machinery that operates through the regulation of multiple GPCRs throughout the hypothalamus.
The cryo-EM structure of hibernating 100S ribosome dimer from pathogenic Staphylococcus aureus
Authors: Matzov Donna , Aibara Shintaro , Basu Arnab , Zimmerman Ella , Bashan Anat , Yap Mee-Ngan F. , Amunts Alexey , Yonath Ada E. 
Published: September 2017

AbstractFormation of 100S ribosome dimer is generally associated with translation suppression in bacteria. Trans-acting factors ribosome modulation factor (RMF) and hibernating promoting factor (HPF) were shown to directly mediate this process in E. coli. Gram-positive S. aureus lacks an RMF homolog and the structural basis for its 100S formation was not known. Here we report the cryo-electron microscopy structure of the native 100S ribosome from S. aureus, revealing the molecular mechanism of its formation. The structure is distinct from previously reported analogs and relies on the HPF C-terminal extension forming the binding platform for the interactions between both of the small ribosomal subunits. The 100S dimer is formed through interactions between rRNA h26, h40, and protein uS2, involving conformational changes of the head as well as surface regions that could potentially prevent RNA polymerase from docking to the ribosome.
Organic flash memory on various flexible substrates for foldable and disposable electronics
Authors: Lee Seungwon , Seong Hyejeong , Im Sung Gap , Moon Hanul , Yoo Seunghyup 
Published: September 2017

AbstractWith the emergence of wearable or disposable electronics, there grows a demand for a flash memory realizable on various flexible substrates. Nevertheless, it has been challenging to develop a flash memory that simultaneously exhibits a significant level of flexibility and performance. This is mainly due to the scarcity of flexible dielectric materials with insulating properties sufficient for a flash memory, which involves dual dielectric layers, respectively, responsible for tunneling and blocking of charges. Here we report ultra-flexible organic flash memories based on polymer dielectrics prepared by initiated chemical vapor deposition. Using their near-ideal dielectric characteristics, we demonstrate flash memories bendable down to a radius of 300 μm that exhibits a relatively long-projected retention with a programming voltage on par with the present industrial standards. The proposed memory technology is then applied to non-conventional substrates, such as papers, to demonstrate its feasibility in a wide range of applications.
Atypical autism in a boy with double duplication of 22q11.2: implications of increasing dosage
Authors: Dale Breanne , Modi Bonnie MacKinnon , Jilderda Sanne , McConnell Beth , Hoang Ny , Swaroop Pooja , Falcon Jhoan , Thiruvahindrapuram Bhooma , Walker Susan , Scherer Stephen W. , Stavropoulos D. James , Drmic Irene E. , Carter Melissa T. 
Published: September 2017

AbstractDuplication of chromosome 22q11.2 (LCR A-D) has been reported at higher frequencies in clinical samples than the general population, but phenotypes vary widely. Triplication (4 copies) is rare, but studying the associated phenotype may provide insight into dosage-sensitivity of the genes in this chromosomal interval. We describe a proband with a triplication, specifically a “double duplication” (two copies per chromosome) of the 22q11.2 region, while his parents and two siblings each have a single duplication (3 copies). The proband had a heart malformation, dysmorphic features, and learning and socialization deficits, whereas the other family members did not. This family illustrates that while duplication of the 22q11.2 may not be sufficient to cause clinically significant neurodevelopmental or health-related phenotypes, triplication of the same region may result in a phenotype characterized by a mild neurodevelopmental disorder, facial dysmorphism, and possibly cardiac anomalies.
Ectopic expression of Triticum aestivum SERK genes (TaSERKs) control plant growth and development in Arabidopsis
Authors: Singh Akanksha , Khurana Paramjit 
Published: September 2017

AbstractSomatic embryogenesis receptor kinases (SERKs) belong to a small gene family of receptor-like kinases involved in signal transduction. A total of 54 genes were shortlisted from the wheat genome survey sequence of which 5 were classified as SERKs and 49 were identified as SERK-like (SERLs). Tissue- specific expression of TaSERKs at major developmental stages of wheat corroborates their indispensable role during somatic and zygotic embryogenesis. TaSERK transcripts show inherent differences in their hormonal sensitivities, i.e. TaSERK2 and TaSERK3 elicits auxin- specific responses while TaSERK1, 4 and 5 were more specific towards BR-mediated regulation. The ectopic expression of TaSERK1, 2, 3, 4 and 5 in Arabidopsis led to enhanced plant height, larger silique size and increased seed yield. Zygotic embryogenesis specific genes showed a differential pattern in TaSERK Arabidopsis transgenics specifically in the silique tissues. Elongated hypocotyls and enhanced root growth were observed in the overexpression transgenic lines of all five TaSERKs. The inhibitory action of auxin and brassinosteroid in all the TaSERK transgenic lines indicates their role in regulating root development. The results obtained imply redundant functions of TaSERKs in maintaining plant growth and development.
General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity
Authors: Ren Gongyi , Zhou Yachun , Liang Ge , Yang Bin , Yang Meirong , King Alexander , Wei Huafeng 
Published: September 2017

AbstractGeneral anesthetics are both neuroprotective and neurotoxic with unclear mechanisms. General anesthetics may control cell survival via their effects on autophagy by activation of type 1 inositol triphosphate receptor (InsP3R-1). DT40 or SH-SY5Y cells with only or over 99% expression of InsP3R-1 were treated with isoflurane or propofol. Cell viability was determined by MTT reduction or LDH release assays. Apoptosis was determined by measuring Caspase-3 or by TUNEL assay. Autophagy activity was determined by measuring LC3 II and P62. We evaluated mitochondrial integrity using MitoTracker Green and cytosolic ATP levels. Fura2-AM was used to measure the concentrations of cytosolic calcium ([Ca2+]c). Propofol significantly increased peak and integrated calcium response (P < 0.001) in cells with InsP3R-1 but not in cells with triple knockout of InsP3R. Both propofol and isoflurane increased autophagy induction (P < 0.05) in an mTOR- and InsP3R- activity dependent manner. Short exposure to propofol adequately activated InsP3-1 to provide sufficient autophagy for cytoprotection, while prolonged exposure to propofol induced cell apoptosis via impairment of autophagy flux through over activation of InsP3-1. Propofol damaged mitochondria and decreased cytosolic ATP. The effects of general anesthetics on apoptosis and autophagy are closely integrated; both are caused by differential activation of the type 1 InsP3R.