bluuebunny/crossref_metadata_2025_split huggingface dataset:
Advanced USC Technology Development in Japan
Authors: Fukuda Masafumi , Saito Eiji , Tanaka Yoshinori , Takahashi Takeo , Nakamura Shinji , Iwasaki Jun , Takano Shinichi , Izumi Sakae 
Published: October 2024

Abstract
The “Cool Earth-Innovative Energy Technology Program,” launched by the Japanese government in March 2008, aims to significantly reduce global greenhouse gas emissions. Among the 21 selected technologies is the Advanced Ultra Super Critical (A-USC) pressure power generation, which targets the commercialization of a 700°C class pulverized coal power system with a power generation efficiency of 46% by around 2015. As of 2004, Japan's pulverized coal power plant capacity reached 35 GW, with the latest plants achieving a steam temperature of 600°C and a net thermal efficiency of approximately 42% (HHV). Older plants from the 1970s and early 1980s, with steam temperatures of 538°C or 566°C, are nearing the need for refurbishment or rebuilding. A case study on retrofitting these older plants with A-USC technology, which uses a 700°C class steam temperature, demonstrated that this technology is suitable for such upgrades and can reduce CO2 emissions by about 15%. Following this study, a large-scale development of A-USC technology began in August 2008, focusing on developing 700°C class boiler, turbine, and valve technologies, including high-temperature material technology. Candidate materials for boilers and turbine rotor and casing materials are being developed and tested. Two years into the project, useful test results regarding these candidate materials have been obtained, contributing to the advancement of A-USC technology.
Mechanical Properties and Microstructure of a Wrought Austenitic Stainless Steel for Advanced Fossil Power Plant Applications
Authors: Gandy D. , Shindledecker J.P , Maziasz P.J. , Maurer G. , Magee J. 
Published: October 2024

Abstract
Advanced Ultra-supercritical (A-USC) steam power-plant technology is being developed for better efficiency and lower emissions at 700°C and above, but is based mainly on Ni-based alloys. The ability to include lower-cost alloys with appropriate high-temperature performance should have substantial technological and economic benefits. CF8C-Plus is a cast austenitic stainless steel recently developed for other applications at 600-900°C, which has creep-strength comparable to many solid-solution Ni-based alloys. EPRI and Carpenter Technology produced a 400 lb heat of CF8C-Plus steel and hot-forged it at 5:1 and 12:1 reductions, to assess feasibility of the alloy as a wrought advanced stainless steel for potential use as steam headers and piping for A-USC power plant applications. The hot-forged alloy has a recrystallized grain structure 6-9 times finer than the as-cast dendritic structure, resulting in better strength and impact resistance at room-temperature, and about 20% higher yield-strength (YS) at 760°C, and similar or better ductility compared to the as-cast material. The initial creep-rupture testing at 700-800°C for up to 2000h also indicates similar or better rupture resistance and better creep-ductility for wrought compared to cast material. The next steps needed to test performance of the wrought austenitic stainless steel for extruded headers and piping are discussed.
Creep Rupture Properties of HR6W for Advanced-USC Boilers
Authors: Saito Nobuhiko , Komai Nobuyoshi 
Published: October 2024

Abstract
HR6W (23Cr-44Ni-7W) is a candidate material for application in the maximum temperature locations of A-USC boilers. In this study the creep rupture properties of plastic deformed, notched, and weldment materials were investigated in comparison with those of solution treated material, in order to clarify the capability of HR6W as a material for A-USC plant application. The deterioration of long term creep rupture strength has been reported with respect to metastable authentic stainless steel due to cold working. However the creep strength of the 20% pre-strained HR6W increased. HR6W creep strength showed notch strengthening behavior. The creep ruptured strength of the GTAW joints was nearly the same as that of the solution treated material, and all specimens fractured within the base metal. The creep ductility of the solution treated materials decreased under low stress conditions. The intergranular fracture is considered to be caused of ductility drop. This tendency is the same as for austenitic stainless steel. The potential of HR6W as a material for A-USC was revealed from the standpoint of creep rupture properties.
Elaboración de artículos científicos en Ciencias de la Educación
Authors: Valverde Batista Reyes Arturo 
Published: October 2024

Introducción: La necesidad que tienen las universidades panameñas de producir artículos científicos, bajo el contexto de las mediciones internacionales de diferentes rankings, conlleva a instruirse en procesos de capacitación intensos que mejoren la calidad. Metodología: Implica la prueba T de muestras emparejadas con el uso del software SPSS, considerando la información obtenida con un cuestionario con preguntas dicotómicas y politómicas como parte del diagnóstico previo al desarrollo del seminario. Durante el seminario se procedió a recopilar a través de una hoja de cálculo de Excel, las estadísticas de la generación y mejora de cada parte de un artículo (introducción, marco teórico, métodos y materiales, etc.) y con ello contrastar los resultados con el requerimiento inicial solicitado, como un antes y un después. Resultados: la capacitación se hace efectiva en 4 de 5 partes de la elaboración de un artículo científico. Discusión: Se rechaza la hipótesis nula al evidenciar las diferencias de las medias al medir las partes de un artículo como la introducción, el marco teórico, la metodología y materiales, los resultados y la discusión; pero no así al momento de someter en los dos momentos al resumen. Conclusión: Se puede afirmar que la debida capacitación en materia de artículos científicos consigue una producción publicable de alta calidad que beneficia a las universidades.
Contributions of Tax Revenue and Government Expenditure to Sustainable Development Goals in Nigeria
Authors: Ubali Chinatu , Okezie Stella Ogechukwu , Alpheaus Ogechi Eberechi , Ihendinihu John Uzoma 
Published: October 2024

This study empirically examined the effect of tax revenue and government expenditure on sustainable development goals in Nigeria. The ex-post facto research design was adopted using time series data sourced from the Central Bank of Nigeria's statistical bulletin and World Bank database. The study covered 22 years from 2001 to 2021. Descriptive and inferential statistical tools were used in analyzing the data after carrying out unit root tests on the stationarity of the series to avoid obtaining invalid and unauthentic regression estimates. The Vector Error Correction Model (VECM) was applied in analyzing the relationship. The study found that Tax Revenue (TR) exhibited a negative and significant effect on sustainable development goals, while Government expenditure (GEXP) indicated a positive and significant effect on Sustainable Development Goals (SDGIS) in the long run. Furthermore, the study revealed that in the short-run Tax Revenue (TR) and Government expenditure (GEXP) both had a negative effect on the SDGIS in Nigeria. There is need for government to develop strategies to broaden the tax base and bring more entities into the tax net while ensuring equitable contribution. They should also align budget allocations with SDG priorities to ensure tax revenue is directed sustainable development projects. Hence the study recommended that government should channel its resources towards closing up infrastructural deficits while increasing productive units that would enhance the economy and ensure optimal utilization of tax revenue towards sustainable developments in Nigeria especially in the achievement of the Sustainable development goals.
Photothermally enhanced antibacterial wound healing using albumin-loaded tanshinone IIA and IR780 nanoparticles
Authors: Chen Haidong , Li Yimei , Chen Dexuan , Fang Yong , Gong Xuchu , Wang Kaikai , Ma Chaoqun 
Published: October 2024

Chronic and infected wounds, particularly those caused by bacterial infections, present significant challenges in medical treatment. This study aimed to develop a novel nanoparticle formulation to enhance wound healing by combining antimicrobial and photothermal therapy using albumin as a carrier for Tanshinone IIA and the near-infrared photothermal agent IR780. The nanoparticles were synthesized to exploit the antimicrobial effects of Tanshinone IIA and the photothermal properties of IR780 when exposed to near-infrared laser irradiation. Characterization of the nanoparticles was performed using Transmission Electron Microscopy (TEM) and spectroscopic analysis to confirm their successful synthesis. In vitro antibacterial activity was evaluated using cultures of methicillin-resistant Staphylococcus aureus (MRSA), and in vivo efficacy was tested in a mouse model of MRSA-infected wounds. Wound healing progression was assessed over 16 days, with statistical analysis performed using two-way ANOVA followed by Tukey’s post-hoc test. The nanoparticles demonstrated significant photothermal properties, enhancing bacterial eradication and promoting the controlled release of Tanshinone IIA. In vitro studies showed superior antibacterial activity, especially under photothermal activation, leading to a substantial reduction in bacterial viability in MRSA cultures. In vivo, nanoparticle treatment combined with near-infrared laser irradiation significantly improved wound closure rates compared to controls and treatments without photothermal activation. By the 16th day post-treatment, significant improvements in wound healing were observed, highlighting the potential of the combined photothermal and pharmacological approach. These findings suggest that albumin-loaded nanoparticles containing Tanshinone IIA and IR780, activated by near-infrared light, could offer an effective therapeutic strategy for managing chronic and infected wounds, promoting both infection control and tissue repair.
First photon-counting detector computed tomography in the living crocodile: a 3D-Imaging study with special reference to amphibious hearing
Authors: Melkersson Karl-Gunnar , Li Hao , Rask-Andersen Helge 
Published: October 2024

BackgroundCrocodiles are semi-aquatic animals well adapted to hear both on land and under water. Currently, there is limited information on how their amphibious hearing is accomplished. Here, we describe, for the first time, the ear anatomy in the living crocodile using photon-counting detector computed tomography (PCD-CT) and 3D rendering. We speculate on how crocodiles, despite their closed ear canals, can use tympanic hearing in water that also provides directional hearing.Material and MethodsA Cuban crocodile (Crocodylus rhombifer) underwent photon-counting detector computed tomography (PCD-CT), under anesthesia and spontaneous respiration. In addition two seven-month-old C. rhombifer and a juvenile Morelet´s crocodile (Crocodylus moreletii) underwent micro-computed tomography (µCT) and endoscopy. One adult Cuviérs dwarf caiman (Paleosuchus palpebrosus) was micro-dissected and video-recorded. Aeration, earflap, and middle ear morphology were evaluated and compared after 3D modeling.Results and DiscussionPCD-CT and µCT with 3D rendering and segmentation demonstrated the anatomy of the external and middle ears with high resolution in both living and expired crocodiles. Based on the findings and comparative examinations, we suggest that the superior earflap, by modulating the meatal recess together with local bone conduction, may implement tympanic hearing in submerged crocodiles, including directional hearing.
Optimization of manufacturing process for serotype 14 pneumococcal capsular polysaccharide
Authors: Li Yuelong , Xu Yongxue , Cao Xin , Wang Yanyan , Wang Jianlong , Zhao Yi , Wang Hui , Yao Hantian , Liu Jiankai 
Published: October 2024

Streptococcus pneumoniae is a pathogenic bacterium that causes infections such as pneumonia, meningitis, otitis media, and bacteremia. The prevention of pneumococcal disease by vaccination has become more urgent due to increased antibiotic resistance. Pneumococcal capsular polysaccharides (CPS) are effective vaccine antigens that stimulate the host to produce protective antibodies. S. pneumoniae serotype 14 is one of most prevalent types in Latin America and across the world. However, the yield of S. pneumoniae serotype 14 CPS from existing fermentation processes remains low and requires improvement. In this study, various aspects of the fermentation process were optimized to improve pneumococcal growth and polysaccharide productivity, including feed medium, cultivation gas environment, fermentation pH, and temperature. A simplified purification method was also developed to obtain pure CPS, including ultrafiltration, acid and ethanol precipitation, diafiltration, and lyophilization. These fermentation optimizations significantly enhanced the optical density of pneumococcal bacterial cultures and increased fermentation yields to 2.4–2.6 g/L—significantly higher than previously achieved. Furthermore, the test results of pure CPS could meet the requirements in the European Pharmacopoeia (11th edition). These optimizations provide valuable insights into the nutritional requirements and impact of varying fermentation process parameters on pneumococcal growth and CPS productivity, thus contributing to the development of a more efficient and cost-effective method for the production of pneumococcal CPS—essential for manufacturing vaccines against pneumococcal infections.
Risk factors for identifying pneumocystis pneumonia in pediatric patients
Authors: Zhang Chunyan , Li Zheng , Chen Xiao , Wang Mengyuan , Yang Enhui , Xu Huan , Wang Shifu 
Published: October 2024

ObjectivesThis study aimed to identify the risk factors and construct the diagnostic model associated with pneumocystis pneumonia (PCP) in pediatric patients.MethodsThis retrospective observational study analyzed 34 cases of PCP and 51 cases of other types of pneumonia treated at Children’s Hospital Affiliated to Shandong University between January 2021 and August 2023. Multivariate binary logistic regression was used to identify the risk factors associated with PCP. Receiver operating characteristic curves and calibration plots were constructed to evaluate the diagnostic model.ResultsTwenty clinical variables significantly differed between the PCP and non-PCP groups. Multivariate binary logistic regression analysis revealed that dyspnea, body temperature&gt;36.5°C, and age&lt;1.46 years old were risk factors for PCP. The area under the curve of the diagnostic model was 0.958, the P-value of Hosmer‐Lemeshow calibration test was 0.346, the R2 of the calibration plot for the actual and predicted probability of PCP was 0.9555 (P&lt;0.001), and the mean Brier score was 0.069. In addition, metagenomic next-generation sequencing revealed 79.41% (27/34) and 52.93% (28/53) mixed infections in the PCP and non-PCP groups, respectively. There was significantly more co-infection with cytomegalovirus and Streptococcus pneumoniae in the PCP group than that in the non-PCP group (p&lt;0.05).ConclusionsDyspnea, body temperature&gt;36.5°C, and age&lt;1.46 years old were found to be independent risk factors for PCP in pediatric patients. The probability of co-infection with cytomegalovirus and S. pneumoniae in the PCP group was significantly higher than that in the non-PCP group.
The impact of pilot policies for low carbon city construction on the development of urban circular economy multiple time-point difference-in-differences model
Authors: Xiao Shumei , Liu Yulan , Rong Jing , Wang Wei 
Published: October 2024

IntroductionAs a means of environmental regulation, the low-carbon city pilot policy aims to address climate change and alleviate environmental resource pressures in economic development. The development of low-carbon cities often requires changes to the existing industrial and energy structures, which will have a significant impact on the regional economy.MethodsThe study is based on panel data from 273 prefecture level cities in China from 2012 to 2022, and uses the Analytic Hierarchy Process and Entropy Comprehensive Evaluation Method to construct an evaluation index system for urban circular benefits. Finally, the multiple time point differences model and mediation effect model were used to evaluate the impact and influencing factors of policies on urban economy.ResultsThe results indicate that at the 1% level, the explanatory variable coefficient significantly improves the level of urban circular economy development after adding control variables. The construction of low-carbon pilot cities has improved the performance of circular economy development by about 6.42%. The mediating effect of industrial structure rationalization is significantly positive at the 1% significance level, indicating that the construction of low-carbon pilot cities has greatly promoted the coordinated development of industrial relations within China’s low-carbon development regions.DiscussionIt can be seen that the low-carbon city pilot policy has a significant promoting effect on China’s economic development and the development of urban circular economy. Therefore, it is recommended to further expand the pilot scope of low-carbon cities and fully leverage their promoting role.
From Sangbo to urban landscape: morphological and hydrological transformations of Xuanwu Lake through integrating historical interpretation and geographic analysis
Authors: Wang Xueyuan , Cheng Yuning 
Published: October 2024

IntroductionXuanwu Lake in Nanjing has undergone a rich history, evolving from native Sangbo to a naval training ground, from an imperial garden to farmland, and finally to a vibrant urban landscape. The lake's legacy can be attributed to its unique geographical and hydrological conditions. Exploring historical transformations of the lake and surrounding landscape patterns provides insights for optimizing urban water space in contemporary China.MethodsTraditional analyses of lake changes based solely on historical records may lack precision due to deviations and artistic interpretations found in ancient maps. However, considering the reciprocal compatibility between local geomorphology, undulating terrains, and water bodies allows for accurate reduction of the lake's morphology by inferring and validating its geographical features. This research combines historical interpretation and geographical analysis to reconstruct the historical shape of Xuanwu Lake, uncover the intrinsic mechanisms driving spatial changes over time, and analyze the morphological changes and connectivity patterns of its hydrological system.ResultsThe morphology and hydrological dynamics of Xuanwu Lake are deeply intertwined with the policies prevailing in different eras. In antiquity, Xuanwu Lake, as a natural body of water, sustained the surrounding ecosystem and the livelihoods of local inhabitants. During the imperial period, it was integrated into the royal gardens, with its utilization and configuration modified by political directives, including the establishment of a naval training facility and its conversion into a royal recreational venue. Subsequently, in response to economic imperatives, Xuanwu Lake was transformed into agricultural land, which led to challenges such as flooding and drought. Ultimately, due to ecological security and recreational needs under urbanization, it was restored to lake form.DiscussionBy interpreting the bidirectional adaptation between the lake's ecosystem functions and city development activities, this research provides insights for water space management and ecological restoration in contemporary Xuanwu Lake. The findings provide guidance for the sustainable development of city-lake relationships to enhance the resilience of urban ecological spaces.
The mechanism underlying B-cell developmental dysfunction in Kawasaki disease based on single-cell transcriptomic sequencing
Authors: Lin Qiuping , Wang Zhen , Ding Guohui , Li Guang , Chen Liqin , Qiu Qingzhu , Song Sirui , Liu Wei , Jiang Xunwei , Huang Min , Shen Libing , Xiao Tingting , Xie Lijian 
Published: October 2024

BackgroundKawasaki disease (KD) is an acute systemic vasculitis that can lead to acquired heart disease in children mostly from in developed countries. The previous research showed that B cells in KD patients underwent a profound change in both the cell numbers and types after intravenous immunoglobulin (IVIG) therapy.MethodsWe performed the single-cell RNA-sequencing for the peripheral blood mononuclear cells (PBMCs) from three febrile patients and three KD patients to investigate the possible mechanism underlying B cell developmental dysfunction in KD. The pseudo-time analysis was employed to study the developmental trajectories of the PBMCs in febrile control and KD patients.ResultsOverall single-cell expression profiles show that the biological processes of immunity, B cell activation pathway and their related biological entities are repressed in KD patients before IVIG treatment compared to febrile patient and KD patients after IVIG treatment. The differentially expressed gene analyses further demonstrate that B cell signaling pathway is downregulated in B cells and plasma blast cells of KD patients before treatment while cell cycle genes and MYC gene are upregulated in dendritic cells (DCs) and hematopoietic stem and progenitor cells (HSPCs) of KD patients before treatment. The biological process of immune response is upregulated in the HSPCs of KD patients before treatment in our dataset while the biological process of inflammatory response is upregulated in the HSPCs of KD patients before treatment in GSE168732 dataset. Single-cell trajectory analyses demonstrate that KD patients before treatment have a shortened developmental path in which B cells and T cells are failed to differentiate into separate lineages. HSPD1 and HSPE1 genes show an elevated expression level in the early cell development stage of KD patients before treatment accompanied with the repression of MYC, SPI1, MT2A and UBE2C genes. Our analyses of all B cells from KD patients before treatment show most of B cells are arrested in a transitional state with an ill developmental path compared with febrile patients and KD patients after treatment.ConclusionOur results indicate that the immune premature HSPCs accompanied with the abnormal expression dynamics of cell cycle and SPI1 genes are the mechanism underlying B cell developmental dysfunction in KD patients.