bluuebunny/crossref_metadata_2025_split huggingface dataset:
A bone graft from the tibial resection or patella that rectified a tibial over‐resection reliably healed and improved clinical outcome scores: A retrospective study of kinematically aligned TKA
Authors: Nedopil Alexander J. , Razick Daniel , Howell Stephen M. , Hull Maury L. 
Published: September 2024

AbstractPurposeDuring kinematically aligned (KA) total knee arthroplasty (TKA), the surgeon may need to rectify an over‐resection of the medial, lateral or posterior tibia. This study tested the hypothesis that a bone graft taken from the tibial resection or patella and impacted beneath a tibial baseplate would heal, regardless of whether the tibial component and knee were in outlier ranges according to mechanical alignment (MA) criteria. The study also tested the hypothesis that the Oxford Knee Score (OKS) and Knee Injury and Osteoarthritis Outcome Score for Joint Replacement (KOOS JR) would improve beyond the substantial clinical benefit and that the source and thickness of the bone graft would not influence their improvement.MethodsThis retrospective study radiographically assessed the healing of a bone graft from the tibial resection (n = 19) or patella (n = 10) in 29 KA TKAs (18 females, mean age 65 years). The tibial component and knee alignment were categorized as in‐range or outliers based on reported MA criteria for bone graft healing and implant survival. The one‐samplettest identified differences in the improvement of the OKS and KOOS JR from their reported substantial clinical benefit of 16 and 20 points, respectively.ResultsAt an average follow‐up of 37 months, all bone grafts healed even though ≥55% of tibial components and 34% of knees were varus outliers according to MA criteria for bone healing and implant survival. Amongst the 29 patients, the mean OKS and KOOS JR improvements of 25 ± 11 and 47 ± 21 points, respectively, surpassed the threshold of their respective substantial clinical benefit (p < 0.01) and were not influenced by the bone graft's source and thickness (p ≥ 0.51).ConclusionsDuring cemented KA TKA, the surgeon can use a bone graft from the tibial resection or patella to rectify a tibial over‐resection. This technique led to consistent bone healing and improved outcome scores.Level of EvidenceLevel IV.
Preventive Effect of Royal Jelly and 10‐HDA on Skin Damage in Diabetic Mice through Regulating Keratinocyte Wnt/β‐Catenin and Pyroptosis Pathway
Authors: Huang Xinqi , Xiu Lu , An Yumei , Gong Yuan , Li Sunao , Chen Xueshi , Liu Chao , Lu Jianghuiwen , Shan Haiyan , Chang Jie , Zhang Mingyang 
Published: September 2024

The objective of this study is to elucidate how Royal jelly (RJ) and 10‐hydroxy‐2‐decanoic acid (10‐HDA) prevents diabetic skin dysfunction by modulating the pyroptosis pathway. Type 2 diabetes models are induced by fat diet consumption and low dose of streptozotocin (STZ) in C57BL/6J mice and treated with RJ (100 mg kg–1 day–1) and 10‐HDA, the major lipid component of royal jelly (100 mg kg−1 day−1) for 28 weeks. The results show that serum concentrations of glucose and triglyceride are significantly lower in the RJ group or 10‐HDA than diabetes mellitus (DM) group. Compared to the control group, pyroptosis proteins, GSDMD, ASC, Caspase‐1, and IL‐1β are increased in the skin of the diabetic model, accompanied by the activation of the Wnt/β‐catenin signal pathway. Further evaluations by RJ exhibit superior improvement of skin damage, repress activation of the Wnt/β‐catenin pathway, and attenuate keratinocyte pyroptosis, but 10‐HDA cannot completely suppress the activation of Wnt/β‐catenin pathway and pyroptosis, which shows a relatively weak protective effect on skin damage which shows that RJ is a better effect on skin injury after DM.
Characterizing the Rise in Dupilumab Prescriptions and Costs: A Medicare Part D Study
Authors: Torabi Sina J. , Patel Rahul A. , Bitner Benjamin F. , Manes R. Peter , Kuan Edward C. 
Published: September 2024

AbstractDupilumab indications have expanded since 2017 Food and Drug Administration (FDA) approval, though evolving prescribing patterns remains to be explored. Annual 2017 to 2021 Medicare Part D claims data was queried. The number of prescribers rose from 142 in 2017 to 6244 in 2021 (r = 0.971; P = .006). Accordingly, the number of Medicare claims and costs both rose, from 2444 to 157,401 (r = 0.986; P = .002) and from $7.59 million to $540.5 million (r = 0.982; P = .003), respectively. While dermatologists made up the bulk of providers in 2017 (78.9%), they only made up 38.1% of providers in 2021. Otolaryngologists were the least represented specialty. In 2021, most providers (98.0%) had only 10 or fewer Medicare patients for whom they prescribed dupilumab. Dupilumab is becoming an increasingly prevalent treatment modality for a variety of indications in the Medicare population. This comes with an incredibly large financial burden on patients and Medicare. The profile of prescribers has changed, mirroring the FDA‐approved indications.
Cobalt‐Doped ZnO Nanocomposits for Efficient Dye Degradation: Charge Transfer
Authors: Abebe Buzuayehu , Kefale Bontu , Amenu Guta , Guta Leta , Ravikumar C. R. , Hamdalla Taymour A. , Giridhar Reddy S. , Tsegaye Dereje , Murthy H. C. Ananda 
Published: September 2024

AbstractDoping enhances the optical properties of high‐band gap zinc oxide nanoparticles (ZnO NPs), essential for their photocatalytic activity. We used the combustion approach to synthesize cobalt‐doped ZnO heterostructure (CDZO). By creating a mid‐edge level, it was possible to tune the indirect band gap of the ZnO NPs from 3.1 eV to 1.8 eV. The red shift and reduction in the intensity of the photoluminescence (PL) spectra resulted from hindrances in electron‐hole recombination and sp‐d exchange interactions. These improved optical properties expanded the absorption of solar light and enhanced charge transfer. The field emission scanning electron microscopy (FESEM) image and elemental mapping analysis confirmed the CDZO′s porous nature and the dopant‘s uniform distribution. The porosity, nanoscale size (25–55 nm), and crystallinity of the CDZO were further verified by high‐resolution transmission electron microscopy (HRTEM) and selected area electron image analysis. The photocatalytic activity of the CDZO exhibited much greater efficiency (k=0.131 min−1) than that of ZnO NPs (k=0.017 min−1). Therefore, doped heterostructures show great promise for industrial‐scale environmental remediation applications.
High‐Pressure Synthesis and Crystal Structure of the Inoborate Ni[B2O2(OH)4]
Authors: Pasqualini Leonard Conrad , Huppertz Hubert 
Published: September 2024

AbstractThe novel inoborate Ni[B2O2(OH)4] was synthesized under high‐pressure/high‐temperature conditions of 9 GPa and 800 °C. Its structure was determined via single‐crystal X‐ray diffraction analysis. The single‐grain IR‐spectrum of Ni[B2O2(OH)4] supports the existence of O−H bonds. The structural similarities and differences with the mineral vimsite, possessing the sum formula Ca[B2O2(OH)4], as well as with the phylloborate HP−Ni(B2O4) is discussed. The title compound can be described as the structural hydrolysis product of the latter.
Ergebnisse
Authors: Tanner Iris 
Published: September 2024

Zusammenfassung Der Ergebnisteil ist so gegliedert, dass zuerst die Tabellen, welche aus der dokumentierten Sichtung hervorgegangen sind, aufgezeigt und beschrieben werden (vgl. Kapitel 7.1), bevor im nächsten Unterkapitel auf die detaillierten deskriptiven und quantitativen Resultate zum Ablauf des Problemlösevorganges (vgl. Kapitel 7.2) und zur Interaktionsstruktur (vgl. Kapitel 7.3) eingegangen wird. Alle diese deskriptiven und quantitativen Ergebnisse ermöglichen eine Situierung der ausgewählten Fälle für die Fallbeschreibungen (vgl. Kapitel 7.4) und Portraits (vgl. Kapitel 7.5) und stellen zugleich die Spannweite der unterschiedlichen Problemlösevorgänge dar sowohl in Bezug auf den fachlichen Aufbau als auch in Bezug auf die sprachlich-interaktiven Aspekte der untersuchten Lehr-Lerngespräche. Um diese Spannweite auf der Mikroebene der verbalen Interaktion deutlicher zu veranschaulichen, sind zudem Steckbriefe von weiteren elf Fällen gemacht worden (vgl. Kapitel 7.6). Am Ende dieses Ergebniskapitels wird eine Gruppierung der im Detail untersuchte Fällen in drei Interaktionsmuster vorgeschlagen (vgl. Kapitel 7.7).
Quality over quantity - rethinking social participation in dementia prevention: results from the AgeWell.de trial
Authors: Kosilek Robert P. , Wendel Flora , Zöllinger Isabel , Knecht Hanna Lea , Blotenberg Iris , Weise Solveig , Fankhänel Thomas , Döhring Juliane , Williamson Martin , Luppa Melanie , Zülke Andrea E. , Brettschneider Christian , Wiese Birgitt , Hoffmann Wolfgang , Frese Thomas , König Hans-Helmut , Kaduszkiewicz Hanna , Thyrian Jochen René , Riedel-Heller Steffi G. , Gensichen Jochen 
Published: September 2024

Abstract
Background
Social participation as a protective factor against cognitive decline was one of the targets in the AgeWell.de study, a multi-domain interventional trial in a sample of older adults at increased risk for dementia. This study aimed to examine differential effects of the intervention and other influencing factors on social participation throughout the trial.

Methods
A longitudinal analysis of study data at the primary follow-up after 24 months (n = 819) was conducted. The Lubben Social Network Scale (LSNS-6) was used to assess quantitative aspects of social networks, and self-reported social activities were classified using a three-tiered categorical framework to capture qualitative aspects.

Results
A positive effect of the intervention was observed at the qualitative framework level, with an OR of 1.38 [95% CI: 1.05–1.82] for achieving or maintaining higher social participation at follow-up, while no effect could be detected on quantitative social network characteristics. Later phases of the Covid-19 pandemic showed a negative impact on the level of social participation at follow-up with an OR of 0.84 [95% CI: 0.75–0.95].

Conclusions
These findings suggest that by focusing on qualitative aspects of social participation as a component of dementia prevention, future interventions can promote enriched social interactions within established social networks.

Trial Registration
German Clinical Trials Register (DRKS) ID DRKS00013555.
Some effects of limited wall-sensor availability on flow estimation with 3D-GANs
Authors: Cuéllar Antonio , Ianiro Andrea , Discetti Stefano 
Published: September 2024

AbstractIn this work we assess the impact of the limited availability of wall-embedded sensors on the full 3D estimation of the flow field in a turbulent channel with $$Re_{\tau }=200$$

R

e
τ

=
200

. The estimation technique is based on a 3D generative adversarial network (3D-GAN). We recently demonstrated that 3D-GANs are capable of estimating fields with good accuracy by employing fully-resolved wall quantities (pressure and streamwise/spanwise wall shear stress on a grid with DNS resolution). However, the practical implementation in an experimental setting is challenging due to the large number of sensors required. In this work, we aim to estimate the flow fields with substantially fewer sensors. The impact of the reduction of the number of sensors on the quality of the flow reconstruction is assessed in terms of accuracy degradation and spectral length-scales involved. It is found that the accuracy degradation is mainly due to the spatial undersampling of scales, rather than the reduction of the number of sensors per se. We explore the performance of the estimator in case only one wall quantity is available. When a large number of sensors is available, pressure measurements provide more accurate flow field estimations. Conversely, the elongated patterns of the streamwise wall shear stress make this quantity the most suitable when only few sensors are available. As a further step towards a real application, the effect of sensor noise is also quantified. It is shown that configurations with fewer sensors are less sensitive to measurement noise.
Morphology and arterial supply of the pyramidalis muscle in an Australian female population using computed tomography angiography
Authors: Short Craig L. , Crotti Tania N. , Algate Kent , Gladman Marc A. , Barras Christen D. 
Published: September 2024

Abstract
Introduction
The structure and function of the human anterolateral abdominal wall have been thoroughly described. However, there has been limited anatomical study of the pyramidalis muscle and its arterial supply. The aim of this study was to analyse the patterns of arterial supply to the pyramidalis in a female population.

Methods
A retrospective study of 32 computed tomography angiography scans of the abdominal wall of adult women was performed to assess the prevalence (bilateral or unilateral presence, or absence), morphology (medial border height, base width and thickness) of pyramidalis and patterns of arterial supply.

Results
Pyramidalis prevalence was bilateral in 75% of computed tomography angiography studies (24/32), unilateral in 6.3% (2/32) and absent in 18.8% (6/32). Of the five patterns of pyramidalis arterial supply observed and described in detail, the most frequent (68%, 34/50 of cases) originated from an exclusive muscular branch of the inferior epigastric artery. Origin from the pubic branch of the inferior epigastric artery was seen in 4% (2/50). There was a single case (2%, 1/50) of artery origin from a variant obturator artery, a common trunk with the pubic branch from the inferior epigastric artery, and from the muscular branch to rectus abdominis. The artery could not be defined in 22% (11/50).

Conclusion
In this computed tomography angiography study of women, five patterns of Pyramidalis arterial supply were identified. In the majority of cases, the pyramidalis derived its arterial supply from an exclusive, isolated muscular branch of the inferior epigastric artery.
Artificial intelligence-based quantification of pulmonary HRCT (AIqpHRCT) for the evaluation of interstitial lung disease in patients with inflammatory rheumatic diseases
Authors: Hoffmann Tobias , Teichgräber Ulf , Lassen-Schmidt Bianca , Renz Diane , Brüheim Luis Benedict , Krämer Martin , Oelzner Peter , Böttcher Joachim , Güttler Felix , Wolf Gunter , Pfeil Alexander 
Published: September 2024

AbstractHigh-resolution computed tomography (HRCT) is important for diagnosing interstitial lung disease (ILD) in inflammatory rheumatic disease (IRD) patients. However, visual ILD assessment via HRCT often has high inter-reader variability. Artificial intelligence (AI)-based techniques for quantitative image analysis promise more accurate diagnostic and prognostic information. This study evaluated the reliability of artificial intelligence-based quantification of pulmonary HRCT (AIqpHRCT) in IRD-ILD patients and verified IRD-ILD quantification using AIqpHRCT in the clinical setting. Reproducibility of AIqpHRCT was verified for each typical HRCT pattern (ground-glass opacity [GGO], non-specific interstitial pneumonia [NSIP], usual interstitial pneumonia [UIP], granuloma). Additional, 50 HRCT datasets from 50 IRD-ILD patients using AIqpHRCT were analysed and correlated with clinical data and pulmonary lung function parameters. AIqpHRCT presented 100% agreement (coefficient of variation = 0.00%, intraclass correlation coefficient = 1.000) regarding the detection of the different HRCT pattern. Furthermore, AIqpHRCT data showed an increase of ILD from 10.7 ± 28.3% (median = 1.3%) in GGO to 18.9 ± 12.4% (median = 18.0%) in UIP pattern. The extent of fibrosis negatively correlated with FVC (ρ=-0.501), TLC (ρ=-0.622), and DLCO (ρ=-0.693) (p < 0.001). GGO measured by AIqpHRCT also significant negatively correlated with DLCO (ρ=-0.699), TLC (ρ=-0.580) and FVC (ρ=-0.423). For the first time, the study demonstrates that AIpqHRCT provides a highly reliable method for quantifying lung parenchymal changes in HRCT images of IRD-ILD patients. Further, the AIqpHRCT method revealed significant correlations between the extent of ILD and lung function parameters. This highlights the potential of AIpqHRCT in enhancing the accuracy of ILD diagnosis and prognosis in clinical settings, ultimately improving patient management and outcomes.
DMD-based spatiotemporal superresolution measurement of a supersonic jet using dual planar PIV and acoustic data
Authors: Kaneko Sayumi , del Pozo Alvaro , Nishikori Hiroki , Ozawa Yuta , Nonomura Taku 
Published: September 2024

AbstractThe present study applies a framework of the spatiotemporal superresolution measurement based on the total-least-squares dynamic mode decomposition, the Kalman filter and the Rauch-Tung-Striebel smoother to an axisymmetric underexpanded supersonic jet of a jet Mach number of 1.35. Dual planar particle image velocimetry was utilized, and paired velocity fields of the flow with a short time interval were obtained at a temporal resolution of 5000 Hz. High-frequency acoustic data of 200,000 Hz were simultaneously obtained. Then, the time-resolved velocity fields of the supersonic jet were reconstructed at a temporal resolution of 200,000 Hz. Also, time coefficients of dynamic modes in high temporal resolution were calculated. The correlation between time coefficients implies that the mixing promotion by screech tone causes the lift-up of the high-velocity fluid from the jet center and accelerates at the downstream side.
Learning curve comparison between switching approach and switching implant in cementless short stem total hip arthroplasty
Authors: Stadler Christian , Bolm Jonas Sebastian , Schopper Clemens , Schauer Bernhard , Holzbauer Matthias , Gotterbarm Tobias , Luger Matthias 
Published: September 2024

Abstract
Introduction
Implementing new approaches or new implants is always related with a certain learning curve in total hip arthroplasty (THA). Currently, many surgeons are switching to minimally invasive approaches combined with short stems for performing THA. Therefore, we aimed to asses and compare the learning curve of switching from an anterolateral Watson Jones approach (ALA) to a direct anterior approach (DAA) with the learning curve of switching from a neck-resecting to a partially neck-sparing short stem in cementless THA.

Materials and methods
The first 150 consecutive THA performed through a DAA (Group A) and the first 150 consecutive THA using a partially neck-sparing short stem (Group B) performed by a single surgeon were evaluated within this retrospective cohort study. All cases were screened for surgery related adverse events (AE). Furthermore, the operative time of each surgery was evaluated and the learning curve assessed performing a cumulative sum (CUSUM) analysis.

Results
Overall, significantly more AE occurred in Group A compared to Group B (18.0% vs. 10.0%; p = 0.046). The sub-analysis of the AE revealed higher rates of periprosthetic joint infections (2.7% vs. 0.7%; p = 0.176), periprosthetic fractures (4.0% vs. 2.0%; p = 0.310) and overall revisions (4.7% vs. 1.3% p = 0.091) within Group A without statistical significance. The CUSUM analysis revealed a consistent reduction of operative time after 97 cases in Group A and 79 cases in Group B.

Conclusion
A significantly higher overall rate of AE was detected while switching approach compared to switching implant for performing THA. However, according to the results of this study, surgeons should be aware of the learning curve of the adoption to a new implant with different fixation philosophy as well.
Patient-reported outcome measures in studies on hallux valgus surgery: what should be assessed
Authors: Spindler F. T. , Ettinger S. , Arbab D. ,   D. A. F. Scientific Committee, Stukenborg-Colsman Christina , Ochman Sabine , Rammelt Stefan , Polzer Hans , Gutteck Natalia , Harrasser Norbert , Plaaß Christian , Baumbach S. F. 
Published: September 2024

Abstract
Introduction
In recent years, there has been an increasing demand for patient-reported outcome measures (PROMs) to assess the outcome following orthopedic surgery. But, we are lacking a standard set of PROMs to assess the outcome of hallux valgus surgery. The aim of this study was to analyze the chosen patient rated outcome scores used in studies reporting on hallux valgus surgery.

Materials and methods
The study was based on a previously published living systematic review. Included were prospective, comparative studies of different surgical procedures or the same procedure for different degrees of deformity. Four common databases were searched for the last decade. Study selection, data extraction, and risk of bias assessment were made by two independent reviewers. Data assessed were the individual PROMs used to assess the outcome of hallux valgus surgery.

Results
46 studies (30 RCTs and 16 non-randomized prospective studies) met the inclusion criteria. The most commonly used clinical outcome measures were the AOFAS (55%) and the VAS (30%). No differences were found between frequency of the individual scores per the level of evidence or the type of osteotomy.

Conclusion
Based on a systematic literature review, the AOFAS and VAS are the most frequently used outcome tools in studies assessing the outcome following hallux valgus surgery. Based on the literature available, the MOXFQ is a more valid alternative.

Level of evidence
Level I; systematic review of prospective comparative (level II) and randomized controlled trials (level I).
Plasma NfL, GFAP, amyloid, and p-tau species as Prognostic biomarkers in Parkinson’s disease
Authors: Pilotto Andrea , Ashton Nicholas J. , Lupini Alessandro , Battaglio Beatrice , Zatti Cinzia , Trasciatti Chiara , Gipponi Stefano , Cottini Elisabetta , Grossi Ilaria , Salvi Alessandro , de Petro Giuseppina , Pizzi Marina , Canale Antonio , Blennow Kaj , Zetterberg Henrik , Padovani Alessandro 
Published: September 2024

Abstract
Introduction
The prognostic role of plasma neurofilament light chain (NfL), phospho-tau, beta-amyloid, and GFAP is still debated in Parkinson’s disease (PD).

Methods
Plasma p-tau181, p-tau231, Aβ1-40, Aβ1-42, GFAP, and NfL were measured by SIMOA in 136 PD with 2.9 + 1.7 years of follow-up and 76 controls. Differences in plasma levels between controls and PD and their correlation with clinical severity and progression rates were evaluated using linear regression analyses.

Results
Patients exhibited similar distribution of plasma biomarkers but higher P-tau181, P-tau231 and lower Aβ1-42 compared with controls. NfL and GFAP correlated with baseline motor and non-motor severity measures. At follow-up, NfL emerged as the best predictor of progression with marginal effect of GFAP and p-tau181 adjusting for age, sex, disease duration, and baseline motor severity.

Conclusion
The present findings confirmed plasma NfL as best predictor of progression in PD, with a marginal role of p-tau181 and GFAP.