bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synopsis of the ASPLOS '16 Wild and Crazy Ideas (WACI) Invited-Speakers Session
Authors: Tsafrir Dan 
Published: June 2016

The Wild and Crazy Ideas (WACI) session is a longstanding tradition at ASPLOS, soliciting talks that consist of forward-looking, visionary, inspiring, creative, far out or just plain amazing ideas presented in an exciting way. (Amusing elements in the presentations are tolerated ;-) but are in fact optional.)
The first WACI session took place in 1998. Back then, the call for talks included a problem statement, which contended that "papers usually do not get admitted to [such conferences as] ISCA or ASPLOS unless the systems that they describe are mature enough to run [some standard benchmark suites, which] has a chilling effect on the idea generation process---encouraging incremental research" [1]. The 1998 WACI session turned out to be a great success. Its webpage states that "there were 42 submissions [competing over] only eight time slots, [which resulted in] this session [having] a lower acceptance rate than the conference itself" [2].
But the times they are a-changin' [3], and the WACI session no longer enjoys that many submissions (Figure 1), perhaps because nowadays there exist many forums for researchers to describe/discuss their preliminary ideas, including: the ``hot topics in'' workshops [4--7]; a journal like CAL, dedicated to early results [8]; main conferences soliciting short submissions describing ``original or unconventional ideas at a preliminary stage'' in addition to regular papers [9]; and the many workshops co-located with main conferences, like ISCA '15, which hosted thirteen such workshops [10].
Regardless of the reason for the declining number of submissions, this time we've decided to organize the WACI session differently to ensure its continued high quality. Instead of soliciting talks via an open call and hoping for the best, we proactively invited speakers whom we believe are capable of delivering excellent WACI presentations. That is, this year's WACI session consists exclusively of invited speakers. Filling up the available slots turned out to be fairly easy, as most of the researchers we invited promptly accepted our invitation. The duration of each talk was set to be eight minutes (exactly as in the first WACI session from 1998) plus two minutes for questions.
The talks are outlined below. We believe they are interesting and exciting, and we hope the attendees of the session will find them stimulating and insightful.
CD44 SNPrs187115: A Novel Biomarker Signature that Predicts Survival in Resectable Pancreatic Ductal Adenocarcinoma
Authors: Stracquadanio Giovanni , Vrugt Bart , Flury Renata , Schraml Peter , Würl Peter , Müller Thomas H. , Knippschild Uwe , Henne-Bruns Doris , Breitenstein Stefan , Clavien Pierre-Alain , Graf Rolf , Bond Gareth L. , Grochola Lukasz F. 
Published: June 2016

Abstract
Purpose: Although pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor, like other common cancers, it displays a wide range of biology. However, at present, there are no reliable tests to predict patients' cancer-specific outcomes and guide personalized treatment decisions. In this study, we aim to identify such biomarkers in resectable PDAC by studying SNPs in the CD44 gene, which drives the progression of pancreatic cancer.
Experimental Design: A total of 348 PDAC patients from three independent cohorts [Switzerland, Germany, The Cancer Genome Atlas (TCGA)] who underwent pancreatic resection are included in the study. Information on the haplotype structure of the CD44 gene is obtained using 1000 Genomes Project data, and the genotypes of the respective tagging SNPs are determined. Cox proportional hazards models are utilized to analyze the impact of SNP genotype on patients' survival.
Results: We identify an SNP in the CD44 gene (SNPrs187115) that independently associates with allelic differences in prognosis in all study cohorts. Specifically, in 121 Swiss patients, we observe an up to 2.38-fold (P = 0.020) difference in tumor-related death between the genotypes of SNPrs187115. We validate those results in both the German (HR = 2.32, P = 0.044, 101 patients) and the TCGA cohort (HR = 2.36, P = 0.044, 126 patients).
Conclusions: CD44 SNPrs187115 can serve as a novel biomarker readily available at the time of PDAC diagnosis that identifies patients at risk for faster tumor progression and guide personalized treatment decisions. It has the potential to significantly expand the pool of patients that would benefit from tumor resection. Clin Cancer Res; 22(24); 6069–77. ©2016 AACR.
O PROCESSO DE ESTRUTURAÇÃO DE RECURSOS NO CONTEXTO DE UMA EMPRESA DE BASE TECNOLÓGICA DE ORIGEM ACADÊMICA (EBTA)
Authors: Silva Sergio Evangelista , Reis Luciana Paula 
Published: June 2016

O sucesso de uma empresa é resultado da configuração de seus recursos e da forma com que ela os emprega de modo a produzir bens e serviços de modo eficiente, sendo estas duas dimensões denominadas estrutural e dinâmica respectivamente. Embora a literatura sobre estas duas dimensões no contexto de empresas convencionais seja vasta, este tema ainda é pouco explorado no contexto do surgimento das Empresas de Base Tecnológica de Origem Acadêmica (EBTAs). Diante desta lacuna teórica, este artigo tem como propósito analisar o processo de estruturação de recursos em uma EBTA, nas diferentes fases de desenvolvimento do negócio. Como estratégia metodológica, foi utilizado o estudo de caso em uma empresa bem sucedida, atuante no ramo de biotecnologia, em que a coleta de dados ocorreu por meio de entrevistas individuais, o que possibilitou obter e analisar os dados concernentes ao tema, sob a ótica da Visão Baseadas nos Recursos (VBR). Para o caso estudado verificou-se que o sucesso foi resultado principalmente da reunião de conhecimentos complementares, nas áreas técnica, gerencial e mercadológica, do capital social dos fundadores, e do estabelecimento de procedimentos sistemáticos de monitoramento do ambiente. A principal contribuição deste estudo está em reconhecer elementos fundamentais para o processo de desenvolvimento dessa empresa.
Neutrophil Proteases Promote Experimental Abdominal Aortic Aneurysm via Extracellular Trap Release and Plasmacytoid Dendritic Cell Activation
Authors: Yan Huimin , Zhou Hui-Fang , Akk Antonina , Hu Ying , Springer Luke E. , Ennis Terri L. , Pham Christine T.N. 
Published: June 2016

Objective—
We previously established that neutrophil-derived dipeptidyl peptidase I (DPPI) is essential for experimental abdominal aortic aneurysm (AAA) development. Because DPPI activates several neutrophil serine proteases, it remains to be determined whether the AAA-promoting effect of DPPI is mediated by neutrophil serine proteases.

Approach and Results—
Using an elastase-induced AAA model, we demonstrate that the absence of 2 neutrophil serine proteases, neutrophil elastase and proteinase-3, recapitulates the AAA-resistant phenotype of DPPI-deficient mice. DPPI and neutrophil serine proteases direct the in vitro and in vivo release of extracellular structures termed neutrophil extracellular traps (NETs). Administration of DNase1, which dismantles NETs, suppresses elastase-induced AAA in wild-type animals and in DPPI-deficient mice reconstituted with wild-type neutrophils. NETs also contain the cathelicidin-related antimicrobial peptide that complexes with self-DNA in recruiting plasmacytoid dendritic cells (pDCs), inducing type I interferons (IFNs) and promoting AAA in DPPI-deficient mice. Conversely, depletion of pDCs or blockade of type I IFNs suppresses experimental AAA. Moreover, we find an abundance of human cathelicidin peptide, a 37 amino acid sequence starting with 2 leucines and the human orthologue of cathelicidin-related antimicrobial peptide, in the vicinity of pDCs in human AAA tissues. Increased type I IFN mRNA expression is observed in human AAA tissues and circulating IFN-α is detected in ≈50% of the AAA sera examined.

Conclusions—
These results suggest that neutrophil protease–mediated NET release contributes to elastase-induced AAA through pDC activation and type I IFN production. These findings increase our understanding of the pathways underlying AAA inflammatory responses and suggest that limiting NET, pDC, and type I IFN activities may suppress aneurysm progression.
Resveratrol Inhibits Aortic Root Dilatation in the Fbn1
C1039G/+
Marfan Mouse Model
Authors: Hibender Stijntje , Franken Romy , van Roomen Cindy , ter Braake Anique , van der Made Ingeborg , Schermer Edith E. , Gunst Quinn , van den Hoff Maurice J. , Lutgens Esther , Pinto Yigal M. , Groenink Maarten , Zwinderman Aeilko H. , Mulder Barbara J.M. , de Vries Carlie J.M. , de Waard Vivian 
Published: June 2016

Objective—

Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the fibrillin-1 gene. Patients with MFS are at risk of aortic aneurysm formation and dissection. Usually, blood pressure–lowering drugs are used to reduce aortic events; however, this is not sufficient for most patients. In the aorta of smooth muscle cell–specific sirtuin-1–deficient mice, spontaneous aneurysm formation and senescence are observed. Resveratrol is known to enhance sirtuin-1 activity and to reduce senescence, which prompted us to investigate the effectiveness of resveratrol in inhibition of aortic dilatation in the
Fbn1
C1039G/+
MFS mouse model.

Approach and Results—
Aortic senescence strongly correlates with aortic root dilatation rate in MFS mice. However, although resveratrol inhibits aortic dilatation, it only shows a trend toward reduced aortic senescence. Resveratrol enhances nuclear localization of sirtuin-1 in the vessel wall and, in contrast to losartan, does not affect leukocyte infiltration nor activation of SMAD2 and extracellular signal–regulated kinases 1/2 (ERK1/2). Interestingly, specific sirtuin-1 activation (SRT1720) or inhibition (sirtinol) in MFS mice does not affect aortic root dilatation rate, although senescence is changed. Resveratrol reduces aortic elastin breaks and decreases micro-RNA-29b expression coinciding with enhanced antiapoptotic Bcl-2 expression and decreased number of terminal apoptotic cells. In cultured smooth muscle cells, the resveratrol effect on micro-RNA-29b downregulation is endothelial cell and nuclear factor κB-dependent.

Conclusions—
Resveratrol inhibits aortic root dilatation in MFS mice by promoting elastin integrity and smooth muscle cell survival, involving downregulation of the aneurysm-related micro-RNA-29b in the aorta. On the basis of these data, resveratrol holds promise as a novel intervention strategy for patients with MFS.
Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy
Authors: Oe Yuji , Hayashi Sakiko , Fushima Tomofumi , Sato Emiko , Kisu Kiyomi , Sato Hiroshi , Ito Sadayoshi , Takahashi Nobuyuki 
Published: June 2016

Objective—
The role of hypercoagulability in the pathogenesis of diabetic nephropathy (DN) remains elusive. We recently reported the increased infiltration of macrophages expressing tissue factor in diabetic kidney glomeruli; tissue factor activates coagulation factor X (FX) to FXa, which in turn stimulates protease-activated receptor 2 (PAR2) and causes inflammation.

Approach and Results—

Here, we demonstrated that diabetes mellitus increased renal
FX
mRNA, urinary FXa activity, and FX expression in glomerular macrophages. Administration of an oral FXa inhibitor, edoxaban, ameliorated DN with concomitant reductions in the expression of PARs (
Par1
and
Par2
) and of proinflammatory and profibrotic genes. Diabetes mellitus induced PAR2, and lack of
Par2
ameliorated DN. FXa or PAR2 agonist increased inflammatory cytokines in endothelial cells and podocytes in vitro.

Conclusions—
We conclude that enhanced FXa and PAR2 exacerbate DN and that both are promising targets for preventing DN. Alleviating inflammation is probably more important than inhibiting coagulation per se when treating kidney diseases using anticoagulants.
Transformation of Legitimacy Concept As Part of Liberal Social Ideal Development
Authors: Кальней  , Kalney Marina 
Published: June 2016

The article considers the transformation of legitimacy
concept. Primary the liberal ideology considered expression of will
of majority as the basis for legitimacy of accepted decisions. However,
dogmatic conception of liberal ideology, growth of elite and mass
opposition caused the danger of growth of authoritarian tendencies
in liberal worldview.
Spectral analysis using Haar wavelet (original signal, denoised signal, residual signal) and source level (SL) for whistle sound of dolphin (Tursiops aduncus) in captivity
Authors: Lubis Muhammad Z. , Wulandari Pratiwi Dwi , Pujiyati Sri , Hestirianoto Totok , Sultan Keni , Mahdi Dwi P. I. , Mujahid Muhammad 
Published: June 2016

This study discussed about Haar wavelet with a view original signal, denoised signal, and residual signal with using fourth whistle sounds of dolphin (Tursiops aduncus). The study was conducted in Safari Park, Cisarua, Bogor Indonesia with 2 dolphins. The results showed differences in results Haar wavelet, this study proves that the Haar wavelet is suitable for the analysis of dolphin sounds, and its have frequency ranged 8-22 kHz. The highest value of the noised signal was smaller than residual signal. The highest of residual signal contained in the second whistle, while the lowest was whistle 1, it showed that the larger the signal denoised result residual signal generated using Haar wavelet. The frequency of source level value ranged 8500 Hz to 11800 Hz, with the highest SL value was 43.9 dB (brown cyrcle). The lowest of the frequency of Source Level (SL) value ranged between 15700 Hz to 17990 Hz, with the lowest SL value was 38.5 dB (brown cyrcle). Whistle 1, 2, 3, and 4 have a different value SL and every SL values obtained in 1,2,3, and 4 have differences noise, it shows the same target but SL value and the sound patterns remain distinct by looking at time duration of whistle sound. Beam pattern from an omni directional sound source (DI= 0 dB, cyan trace) and a directional source following the piston model (DI= 18 dB, black trace) and beam pattern with 4 types signal have ranged value 70 º-180°, with highest intensity value was 60º.
Quantum plasmonics: from jellium models to ab initio calculations
Authors: Varas Alejandro , García-González Pablo , Feist Johannes , García-Vidal F.J. , Rubio Angel 
Published: June 2016

AbstractLight-matter interaction in plasmonic nanostructures is often treated within the realm of classical optics. However, recent experimental findings show the need to go beyond the classical models to explain and predict the plasmonic response at the nanoscale. A prototypical system is a nanoparticle dimer, extensively studied using both classical and quantum prescriptions. However, only very recently, fully ab initio time-dependent density functional theory (TDDFT) calculations of the optical response of these dimers have been carried out. Here, we review the recent work on the impact of the atomic structure on the optical properties of such systems. We show that TDDFT can be an invaluable tool to simulate the time evolution of plasmonic modes, providing fundamental understanding into the underlying microscopical mechanisms.
Crystal structure of N′-(4-nitrobenzylidene)-5-phenyl-1H-pyrazole-3-carbohydrazide, C17H13N5O3
Authors: Karrouchi Khalid , Radi Smaail , Ansar M’hammed , Taoufik Jamal , Ghabbour Hazem A. , Mabkhot Yahia N. 
Published: June 2016

Abstract
C17H13N5O3, monoclinic, P21/c (no. 14), a = 20.1049(8) Å, b = 11.1534(4) Å, c = 6.8890(3) Å, β = 97.224(2)°, V = 1532.51(11) Å3, Z = 4, R
gt
(F) = = 0.0451, wR
ref
(F
2
) = 0.1153, T = 100 K.
Effect of Adding Dexamethasone as a Ropivacaine Adjuvant in Ultrasound-Guided Transversus Abdominis Plane Block for Inguinal Hernia Repair
Authors: Kartalov Andrijan , Jankulovski Nikola , Kuzmanovska Biljana , Zdravkovska Milka , Shosholcheva Mirjana , Spirovska Tatjana , Petrusheva Aleksandra Panovska , Tolevska Marija , Srceva Marija , Durnev Vesna , Jota Gjorgji , Selmani Redzep , Sivevski Atanas 
Published: June 2016

Abstract
Background: The transverses abdominals plane block (TAP) is a regional anesthesia technique that provided analgesia to the parietal peritoneum, skin and muscles of the anterior abdominal wall. The aim of this randomized double-blind study was to evaluate postoperative analgesia on patients undergoing open inguinal hernia repair under general anesthesia (GA), (GA + TAP) block preformed with ropivacaine and (GA + TAP-D) block preformed with ropivacaine and 4 mg dexamethasone.
Methods: 90 (ASA I-II) adult patients for unilateral open inguinal hernia repair were included in this study. In group I (n = 30) patents received only general anesthesia (GA). Patients in group II (n = 30) received GA and unilateral TAP block with 25 ml of 0.5% ropivacaine and the patients in group III (n = 30) received GA and unilateral TAP-D block with 25 ml of 0.5% ropivacaine + 4 mg Dexamethadsone. In this study we assessed the pain score - VAS at rest at 2, 4, 6, 12 and 24 hours after the operation and the total analgesic consumption of morphine over 24 hours.
Results: There were statistically significant differences in the VAS scores between group I, group II and group III at all postoperative time points - 2hr, 4hr, 6hr, 12hr and 24hr. (p < 0.00001). The cumulative 24 hours morphine consumption after the operation was significantly lower in group III (5.53 1.21 mg) than in group II (6.16 2.41 mg) and group I (9.26 2.41 mg). This difference is statistically significant (p < 0.00001).
Conclusion: Concerning the inguinal hernia repair we found better postoperative pain scores and 24 hours reduction of the morphine consumption in group III (GA and TAP-D block) compared with group I (GA) and group II (GA + TAP block).
The Effects of Vasospasm and Re-Bleeding on the Outcome of Patients with Subarachnoid Hemorrhage from Ruptured Intracranial Aneurysm
Authors: Filipce Venko , Caparoski Aleksandar 
Published: June 2016

Abstract
Vasospasm and re-bleeding after subarachnoid hemorrhage from ruptured intracranial aneurysm are devastating complication that can severely affect the outcome of the patients. We are presenting a series of total number of 224 patients treated and operated at our Department due to subarachnoid hemorrhage, out of which certain number developed vasospasm and re-bleeding. We are evaluating the effect of these complications on the outcome of the patients according to the Glasgow Outcome Scale at the day of discharge. In our experience both vasospasm and ReSAH can significantly influence the outcome of patients with subarachnoid hemorrhage from ruptured intracranial aneurysm.
Influence of Climate Changes on Health (Review)
Authors: Pop-Jordanova Nada , Grigorova Evgenija 
Published: June 2016

Abstract
Although climate changes are one of the most serious public health risks for all nations, it appears that the medical society in the East European countries is not too much concerned.
The aim of this paper is to point out the main treats on health provoked by climate changes.
The literature review was the source of information. Based on the PubMed where in 2015 more than 65,000 papers were dedicated to different aspects of the influence of the climate changes on the human health, as well as 3,500 articles for the pediatric population, we present a review of the main health risks. Especially, the impact of the climate changes on the children′s health is overviewed.
In separate parts, the thermal stress, extreme weather events, changes of infection′s pattern, how to measure health risks as well as some mitigation measures are discussed.
Patientenpräferenzen: Methoden und internationale Entwicklungen
Authors: Mühlbacher Axel , Juhnke Christin 
Published: June 2016

Zusammenfassung:
Grundlage von klinischen und ökonomischen Entscheidungen im Gesundheitswesen ist der Nutzen für den Patienten. Patientenpräferenzen, als Ausdruck des Patientennutzens, können und sollten auf allen Ebenen in die Entscheidungsprozesse einbezogen werden.
Frühkindliche Karies – Verhaltens- und verhältnispräventive Ansätze
Authors: Wolfram Nicole , Schütte Ursula 
Published: June 2016

Zusammenfassung:
Trotz guter Erfolge bei der Kariesprophylaxe sind steigende Prävalenzen im frühen Kindesalter beobachtbar. Grund hierfür ist eine unzureichend konsequente Durchführung der Mundhygiene bei einer stark zuckerhaltigen Ernährung. Im Sinne des Gesundheitszieles „Gesund aufwachsen“ sind neben effektiven verhaltenspräventiven Maßnahmen auch wirkungsvolle strukturelle verhältnispräventive Ansätze nötig. Exemplarisch wird die Maßnahme: „Kariesfrei – Wir sind dabei. Die Putzbande deckt auf!“ dargestellt.
Individualisierte Medizin bei ausgewählten Krebserkrankungen
Authors: Plöthner Marika , Zeidler Jan , Graf von der Schulenburg Johann-Matthias 
Published: June 2016

Zusammenfassung:
Durch zielgerichtete Therapien (TT) wurden bereits in einigen onkologischen Indikationen Verbesserungen in der Behandlung erzielt. Für Lungenkrebs sind bisher 5 und für Brustkrebs 11 Substanzen zur TT zugelassen. Somit konnten beispielsweise Erhöhungen der Überlebenszeit und ein verbessertes Therapieansprechen bei EGFR-positiven Lungenkrebs-Patienten oder auch Verbesserungen der Lebensqualität bei Brustkrebspatienten nachgewiesen werden. Einem breiten Einsatz von TT stehen jedoch aktuell einige medizinische und ökonomische Herausforderungen entgegen.
Die Verbreitung von Risikofaktoren für Herz-Kreislauf-Erkrankungen in der Bevölkerung
Authors: Oertelt-Prigione Sabine 
Published: June 2016

Zusammenfassung:
Herzkreislauferkrankungen stellen die häufigste Todesursache weltweit dar. Die Mehrzahl dieser Erkrankungen kann auf eine begrenzte Anzahl modifizierbarer Risikofaktoren zurückgeführt werden. Geschlechtsspezifische, kulturbedingte und sozioökonomische Faktoren beeinflussen die Risikofaktorprävalenz. Diese Aspekte sollten bereits bei der Erhebung berücksichtigt werden, um die Entwicklung von nutzerzentrierten Präventionsmaßnahmen zu unterstützen.
Psychische Störungen bei Patienten mit chronischen körperlichen Erkrankungen
Authors: Serbanescu Ilinca , Baumeister Harald 
Published: June 2016

Zusammenfassung:
Klinische und epidemiologische Studien belegen, dass psychische Störungen häufige Begleiterscheinungen chronischer körperlicher Erkrankungen darstellen. Obwohl die rechtzeitige und korrekte Erkennung der somatopsychischen Komorbidität bedeutsame Implikationen für die Therapie und den Verlauf der assoziierten Erkrankungen hat, findet sie nur in einem begrenzten Teil der Fälle statt. Dabei kann eine frühzeitige Diagnostik und Behandlung der komorbiden psychischen Störung das Ausmaß ihrer Symptomatik verringern und die Lebensqualität der doppeltbelasteten Patienten entscheidend verbessern.