bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tenosynovitis caused by Mycobacterium malmoense in two kidney transplant recipients and review of the literature
Authors: van Grootveld Rebecca , Scherer Hans U. , Peters Elke E. M. , Gaasbeek André , Arend Sandra M. , Wunderink Herman F. 
Published: November 2017

AbstractWe report two unrelated cases of tenosynovitis caused by Mycobacterium malmoense in kidney transplant recipients. Both patients received immunosuppression and were referred to our tertiary hospital because of persisting complaints lasting >6 months not responding to corticosteroids or surgery. The mycobacterial cultures were positive for the slow‐growing M. malmoense after several weeks of incubation. The patient in Case 1 was treated with a combination of surgical debridement and antibiotics, whereas the patient in Case 2 was only treated surgically. Both cases illustrate the doctor's delay in diagnosing mycobacterial infections, and remind us that nontuberculous mycobacterial infections should be part of the differential diagnosis of tenosynovitis, especially in immunocompromised patients.
Proteomic analysis of lysine acetylation provides strong evidence for involvement of acetylated proteins in plant meiosis and tapetum function
Authors: Li Xiaojing , Ye Juanying , Ma Hong , Lu Pingli 
Published: November 2017

SummaryProtein lysine acetylation (KAC) is a dynamic and reversible post‐translational modification that has important biological roles in many organisms. Although KAC has been shown to affect reproductive development and meiosis in yeast and animals, similar studies are largely lacking in flowering plants, especially proteome‐scale investigations for particular reproductive stages. Here, we report results from a proteomic investigation to detect the KAC status of the developing rice anthers near the time of meiosis (RAM), providing strong biochemical evidence for roles of many KAC‐affected proteins during anther development and meiosis in rice. We identified a total of 1354 KAC sites in 676 proteins. Among these, 421 acetylated proteins with 629 KAC sites are novel, greatly enriching our knowledge on KAC in flowering plants. Gene Ontology enrichment analysis showed chromatin silencing, protein folding, fatty acid biosynthetic process and response to stress to be over‐represented. In addition, certain potentially specific KAC motifs in RAM were detected. Importantly, 357 rice meiocyte proteins were acetylated; and four proteins genetically identified to be important for rice tapetum and pollen development were acetylated on 14 KAC sites in total. Furthermore, 47 putative secretory proteins were detected to exhibit acetylated status in RAM. Moreover, by comparing our lysine acetylome with the RAM phosphoproteome we obtained previously, we proposed a correlation between KAC and phosphorylation as a potential modulatory mechanism in rice RAM. This study provides the first global survey of KAC in plant reproductive development, making a promising starting point for further functional analysis of KAC during rice anther development and meiosis.
Recovery from temporary endoplasmic reticulum stress in plants relies on the tissue‐specific and largely independent roles of bZIP28 and bZIP60, as well as an antagonizing function of BAX‐Inhibitor 1 upon the pro‐adaptive signaling mediated by bZIP28
Authors: Ruberti Cristina , Lai YaShiuan , Brandizzi Federica 
Published: November 2017

SummaryThe unfolded protein response (UPR) is an ancient signaling pathway that commits to life‐or‐death outcomes in response to proteotoxic stress in the endoplasmic reticulum (ER). In plants, the membrane‐tethered transcription factor bZIP28 and the ribonuclease‐kinase IRE1 along with its splicing target, bZIP60, govern the two cytoprotective UPR signaling pathways known to date. The conserved ER membrane‐associated BAX inhibitor 1 (BI1) modulates ER stress‐induced programmed cell death through yet‐unknown mechanisms. Despite the significance of the UPR for cell homeostasis, in plants the regulatory circuitry underlying ER stress resolution is still largely unmapped. To gain insights into the coordination of plant UPR strategies, we analyzed the functional relationship of the UPR modulators through the analysis of single and higher order mutants of IRE1, bZIP60, bZIP28 and BI1 in experimental conditions causing either temporary or chronic ER stress. We established a functional duality of bZIP28 and bZIP60, as they exert partially independent tissue‐specific roles in recovery from ER stress, but redundantly actuate survival strategies in chronic ER stress. We also discovered that BI1 attenuates the pro‐survival function of bZIP28 in ER stress resolution and, differently to animal cells, it does not temper the ribonuclease activity of inositol‐requiring enzyme 1 (IRE1) under temporary ER stress. Together these findings reveal a functional independence of bZIP28 and bZIP60 in plant UPR, and identify an antagonizing role of BI1 in the pro‐adaptive signaling mediated by bZIP28, bringing to light the distinctive complexity of the unfolded protein response (UPR) in plants.
Median sternotomy versus intercostal thoracotomy for lung lobectomy: A comparison of short‐term outcome in 134 dogs
Authors: Bleakley Seth , Phipps Kevin , Petrovsky Brian , Monnet Eric 
Published: November 2017

AbstractObjectiveTo compare short‐term outcomes between dogs undergoing lung lobectomy via median sternotomy (MS) or intercostal thoracotomy (ICT).Study designRetrospective case control study.MethodsMedical records of dogs that underwent lung lobectomy via MS or ICT at a single institution were reviewed for demographics, intraoperative findings, and postoperative management and outcomes. Dogs with pleural effusion, pneumonia, migrating foreign body, lung abscess, spontaneous pneumothorax, or lung lobe torsion were excluded. Short‐term outcome factors up were compared up to the time of death, euthanasia, or discharge from the hospital.ResultsOne hundred and thirty‐four dogs met the inclusion criteria. Forty‐one (31%) dogs underwent MS and 93 dogs (69%) underwent ICT. Fluid production from the chest tube (P = .0061), alveolar arterial pressure gradient (P = .0001), and complications requiring intervention (P = .0245) were more common in the MS group than the ICT group. Pain management and all other short‐term outcome factors did not differ between procedures. Five dogs from the MS group and 4 from the ICT group were euthanized in the postoperative period (P = .0925).ConclusionIn a surgical procedure that does not preclude either approach, ICT may be more desirable than MS in terms of postoperative pain, oxygenation, and complications. However, since no other short‐term measure of outcome differed, we can state that both MS and ICT are well tolerated by dogs.
Evaluating social work supervision
Authors: Davys Allyson Mary , May Janet , Burns Beverly , O’Connell Michael 
Published: November 2017

INTRODUCTION: The question of whether the practice of professional supervision is effective, and how its effectiveness can be measured, has been debated by both social work and other professions. This study explored how practitioners, supervisors and managers in Aotearoa New Zealand currently evaluate the supervision they receive, provide and/or resource. The study was interprofessional involving counsellors, mental health nurses, psychologists and social workers. This article focuses on the findings from the social work cohort.METHODS: Through an on-line Qualtrics survey participants were asked: 1) how they currently evaluated professional/clinical supervision; and 2) how they thought professional/clinical supervision could be evaluated. Data were extracted through the Qualtrics reporting functions and thematic analysis was used to identify themes. A total of 329 participants completed the survey of which 145 (44%) were social workers. FINDINGS: A majority of the social work participants reported that they evaluated supervision in some form. No culture or policy emerged regarding supervision evaluation, but social workers expressed interest in training and resources to assist evaluation and some saw a supportive and endorsement role for the professional or regulatory bodies. An unexpected finding was reports of unsatisfactory and harmful supervision.CONCLUSION: Evaluation of supervision is an activity with which social workers engage, but further research is needed to explore how evaluation can be embedded in supervision practice. More critically, a broader audit is required to reconsider the definition and model of social work supervision in Aotearoa New Zealand and the environments within which supervision occurs.
Genome Sequences of Chancellor, Mitti, and Wintermute, Three Subcluster K4 Phages Isolated Using Mycobacterium smegmatis mc
2
155
Authors: Edgington Nicholas P. , Voshell Stephanie M. , Ware Vassie C. , Akoto Francis F. , Alhout Alexa A. , Atwal Gurvina J. , Balyozian John B. , Cadieux Zachary A. , Chop Brianna M. , Cresawn Steven G. , Cudkevich Netta , Faltine-Gonzalez Dylan Z. , Garlena Rebecca A. , Gilmer Blair J. , Graham Lee H. , Grapel Matthew S. , Haleem Maaz M. , Jacobs-Sera Deborah , Kenna Margaret A. , Khan Maryam A. , Klein Taylor N. , Korenberg Jamie B. , Lichak Brooke P. , Mageeney Catherine M. , McKinley Lauren N. , Mendello Kourtney R. , Myers Cameron M. , Nguyen Alexander T. , Pasqualucci Bryan A. , Pope Welkin H. , Pyfer Lauren M. , Ramirez Wascar A. , Reisner Julia R. , Russell Daniel A. , Sapao Paulene A. , Saux Virginia C. , Singh Inderjeet , Stoner Ty H. , Swope Rachel H. , Thoonkuzhy Matthew J. , Walters Madeleine L. , Vargas Lauren A. , Veliz Croldy A. , Zhang Kevin D. , Zuilkoski Caitlin M. , Hatfull Graham F. 
Published: November 2017

ABSTRACT

Mycobacteriophages Chancellor, Mitti, and Wintermute infect
Mycobacterium smegmatis
mc
2
155 and are closely related to phages Cheetobro and Fionnbharth in subcluster K4. Genome sizes range from 57,697 bp to 58,046 bp. Phages are predicted to be temperate and to infect the pathogen
Mycobacterium tuberculosis
.
Genome Sequences of Subcluster K5 Mycobacteriophages AlleyCat, Edugator, and Guillsminger
Authors: King Rodney A. , Slowan-Pomeroy Tina M. , Thomas Jodi E. , Ahmed Tithe , Alexander Katie L. , Biddle James M. , Daniels Makenzie K. , Rowlett Jenna R. , Senay Taylor E. , Rinehart Claire A. , Staples Amanda K. , Rowland Naomi S. , Gaffney Bobby L. , Emmons Christine B. , Hauk Maya D. , Nguyen Rebecca L. , Naegele Leonard , Strickland Summer S. , Briggs Laura A. , Rush Alexander N. , Saha Sanghamitra , Sadana Rachna , Cresawn Steven G. , Russell Daniel A. , Garlena Rebecca A. , Pope Welkin H. , Jacobs-Sera Deborah , Hatfull Graham F. 
Published: November 2017

ABSTRACT

Bacteriophages AlleyCat, Edugator, and Guillsminger were isolated on
Mycobacterium smegmatis
mc
2
155 from enriched soil samples. All are members of mycobacteriophage subcluster K5, with genomes of 62,112 to 63,344 bp. Each genome contains 92 to 99 predicted protein-coding genes and one tRNA. Guillsminger is the first mycobacteriophage to carry an IS
1380
family transposon.
Genome Sequence of a Porcine Bocavirus Detected in Feces of Domestic Minks in China
Authors: Wang Yan , Zhao Jing , Zheng Min , Liu Zhijian , Yuan Jiaqi , Zhao Jieji , Shen Quan , Fan Zhaobin , Jiang Lili , Yang Shixing 
Published: November 2017

ABSTRACT
We report here the genome sequence of porcine bocavirus strain PBov-JZ08, which was isolated from mink feces in China. Sequence analysis implied that PBov-JZ08 clustered with three porcine bocaviruses.
Draft Genome Sequence of a Methicillin-Resistant Sequence Type 39 Staphylococcal Isolate Obtained from Seafood
Authors: Sivaraman G. K. , Vanik Deesha , Visnuvinayagam S. , Prasad Mothadaka Mukteswar , Murugadas V. , Nadella Ranjit Kumar , Ravishankar C. N. 
Published: November 2017

ABSTRACT

The draft genome sequence of a methicillin-resistant
Staphylococcus aureus
(MRSA) sequence type 39 (ST 39) isolate obtained from the dried ribbonfish of Gujarat, India, is reported here.
Staphylococcus
-specific genes were present in this MRSA isolate. The whole-genome sequence of this strain contains 2,693 protein-coding genes and 70 RNAs within the 2.82-Mb genome.
Genome Sequence of Fusarium graminearum ITEM 124 (ATCC 56091), a Mycotoxigenic Plant Pathogen
Authors: Zapparata Antonio , Da Lio Daniele , Somma Stefania , Vicente Muñoz Isabel , Malfatti Luca , Vannacci Giovanni , Moretti Antonio , Baroncelli Riccardo , Sarrocco Sabrina 
Published: November 2017

ABSTRACT

Fusarium graminearum
is among the main causal agents of
Fusarium
head blight (FHB), or scab, of wheat and other cereals, caused by a complex of
Fusarium
species, worldwide. Besides causing economic losses in terms of crop yield and quality,
F. graminearum
poses a severe threat to animal and human health. Here, we present the first draft whole-genome sequence of the mycotoxigenic
Fusarium graminearum
strain ITEM 124, also providing useful information for comparative genomics studies.
Draft Genome Sequences of Nonclinical and Clinical Enterobacter cloacae Isolates Exhibiting Multiple Antibiotic Resistance and Virulence Factors
Authors: Mishra Mitali , Patole Shashank , Mohapatra Harapriya 
Published: November 2017

ABSTRACT

Enterobacter
spp. have been implicated as opportunistic pathogens which over the years have gained resistance toward most of the available therapeutic drugs. We sequenced two multidrug-resistant
Enterobacter cloacae
isolates harboring multiple efflux pump genes. These isolates exhibited strain-specific modulation of efflux pump protein expression.
Whole-Genome Sequencing of
Lactobacillus
Species from Two Commercial Probiotic Products
Authors: Colavecchio Anna , Leo Victoria , Zaccheo Sophia , Jeukens Julie , Emond-Rheault Jean-Guillaume , Hamel Jérémie , Kukavica-Ibrulj Irena , Levesque Roger C. , Goodridge Lawrence 
Published: November 2017

ABSTRACT

Eight
Lactobacillus
strains, each intrinsically resistant to an antibiotic, were isolated from two commercial probiotic products. Whole-genome sequencing identified two efflux transporters, a multidrug and extrusion protein (MATE) efflux transporter, and LmrCD, which may contribute to their intrinsic antibiotic resistance and may therefore facilitate their survival in the intestinal microbiota following antibiotic therapy.
Complete Genome Sequence of a Novel Human Papillomavirus Isolated from Oral Rinse
Authors: Chen Zigui , Wong Martin C. S. , Wong Po Yee , Ho Wendy C. S. , Liang Miaoyin , Yeung Apple C. M. , Chan Paul K. S. 
Published: November 2017

ABSTRACT

A novel human papillomavirus (HPV TG550) isolated from the oral rinse of a Chinese male resident was fully characterized. The L1 open reading frame of HPV TG550 shares 82.5% nucleotide sequence similarity with its closest relative, HPV166, and clusters within the species group
Gammapapillomavirus 19
.
Enterococci and Their Interactions with the Intestinal Microbiome
Authors: Dubin Krista , Pamer Eric G. 
Published: November 2017

ABSTRACT

The
Enterococcus
genus comprises over 50 species that live as commensal bacteria in the gastrointestinal (GI) tracts of insects, birds, reptiles, and mammals. Named “entero” to emphasize their intestinal habitat,
Enterococcus faecalis
and
Enterococcus faecium
were first isolated in the early 1900s and are the most abundant species of this genus found in the human fecal microbiota. In the past 3 decades, enterococci have developed increased resistance to several classes of antibiotics and emerged as a prevalent causative agent of health care-related infections. In U.S. hospitals, antibiotic use has increased the transmission of multidrug-resistant enterococci. Antibiotic treatment depletes broad communities of commensal microbes from the GI tract, allowing resistant enterococci to densely colonize the gut. The reestablishment of a diverse intestinal microbiota is an emerging approach to combat infections caused by antibiotic-resistant bacteria in the GI tract. Because enterococci exist as commensals, modifying the intestinal microbiome to eliminate enterococcal clinical pathogens poses a challenge. To better understand how enterococci exist as both commensals and pathogens, in this article we discuss their clinical importance, antibiotic resistance, diversity in genomic composition and habitats, and interaction with the intestinal microbiome that may be used to prevent clinical infection.
Individualised advance care planning in children with life-limiting conditions
Authors: Loeffen Erik A H , Tissing Wim J E , Schuiling-Otten Meggi A , de Kruiff Chris C , Kremer Leontien C M , Verhagen A A Eduard 
Published: November 2017

IntroductionIn 2013, the Pediatric Association of the Netherlands launched an evidence-based guideline ‘Palliative care for children’. To promote implementation in daily practice and hereby improve quality of paediatric palliative care, we aimed to develop a functional individualised paediatric palliative care plan (IPPCP) that covers physical, psychological, spiritual and social functioning, with great emphasis on the guideline’s recommendations, advance care planning and patients’ and parents’ preferences and desires.MethodsA Dutch working group (28 individuals) with a strong multidisciplinary character developed a draft IPPCP, which was piloted retrospectively and prospectively. In the pilots we completed, the IPPCPs for patients who were recently diagnosed with a life-threatening or life-limiting condition and evaluated completeness, usability and user-friendliness.ResultsThe final IPPCP comprised five domains: (1) IPPCP data, (2) basics, (3) social, (4) psychosocial and spiritual and (5) physical care. Each domain covered various components. In both pilots, the IPPCP was considered a comprehensive document that covered all areas of paediatric palliative care and was experienced as an improvement to the present situation. However, the current form was regarded to lack user-friendliness.ConclusionWe propose a set of essential components of a comprehensive IPPCP for paediatric palliative care with extra attention for advance care planning and anticipatory action. Patients’ and parents’ preferences and desires are included next to the recommendations of the evidence-based guideline ‘Palliative care for children’.
Effect of regular exercise training on changes in HbA1c, BMI and VO2max among patients with type 2 diabetes mellitus: an 8-year trial
Authors: Najafipour Farzad , Mobasseri Majid , Yavari Abbas , Nadrian Haidar , Aliasgarzadeh Akbar , Mashinchi Abbasi Naimeh , Niafar Mitra , Houshyar Gharamaleki Jalil , Sadra Vahideh 
Published: November 2017

ObjectiveThe effects of regular exercise on the health promotion of patients with type 2 diabetes mellitus (T2DM) have been well documented. The present study investigated the long-term effects of regular exercise training on biological indicators among these patients.MethodsIn this quasi-experimental trial with pretest-post-test design, 65 patients with T2DM aged 33–69 years (experiment (35), control (30)) participated. After 8 years of conducting the program, the data on 30 patients (experiment (15), control (15)) were entered into analysis. The training program included aerobic exercise three sessions per week, 90 min, 50%–80% VO2max. Before and after the intervention, the biological indicators (hemoglobin A1c (HbA1c), body mass index (BMI) and VO2max) were measured. Data were analyzed using multivariate analysis of covariance.ResultsOur long-term exercise training program had a significant effect on HbA1C, BMI and Vo2max (P<0.05). Compared with patients in the control group, HbA1c was significantly reduced and BMI and VO2max were significantly improved among the experiment group.ConclusionsLong-term regular physical activity training was found to be helpful in improving glycemic control, body composition and cardiovascular fitness among patients with T2DM. Long-term continuous physical activity offsets the deteriorations of biological indicators found in the control group. Further research, with a particular focus on practical and real-world programming, is needed to determine the responsive health outcomes of such long-term programs on the patients.
Exploring the characteristics of the high-cost population from the family perspective: a cross-sectional study in Jiangsu Province, China
Authors: Miao Yudong , Qian Dongfu , Sandeep Sandeep , Ye Ting , Niu Yadong , Hu Dan , Zhang Liang 
Published: November 2017

BackgroundAcross a range of healthcare settings, 5% of the population accounts for half of healthcare spending: these patients are identified as a ‘high-cost population’. Characterising high-cost users is essential for predicting potential high-cost patients and the development of appropriate interventions to improve the management and financing of these patients.ObjectiveThis cross-sectional study aimed to explore the characteristics of this high-cost population from a family perspective in China and provide suggestions for social health insurance policy development.MethodsThis study used data from the Fifth Health Service Investigation of Jiangsu Province (2013), and 12 600 families were enrolled for analysis. Households whose medical expenditures were among the top 5% were identified to be high-cost families. A t-test, a Χ2test, and a binary logistic regression were used.ResultsHigh-cost families (n=631, 5%) accounted for 44.9% of the total medical expenditure of sampled families. High-cost families had 3.2 members and 1.2 chronic disease patients per household, which is significantly more than the 2.9 members and 0.7 people in the remaining families, respectively (p<0.05). Bi-weekly emergency department visits and annual hospitalisations preceding the household investigation of high-cost families were 1.19 and 0.98 per household, which is significantly more than the 0.68 and 0.17 of the remaining families, respectively (p<0.05). A binary logistic regression indicated that the number of family members (OR 1.152), the number of chronic disease patients (OR 1.508), bi-weekly emergency department visits (OR 1.218), and annual hospitalisations (OR 4.577) were associated with high costs.ConclusionThe 5% high-cost families in Jiangsu Province accounted for approximately half of medical expenditures. The effectiveness of Chinese Social Health Insurance in lowering high-cost families’ risk of catastrophic health expenditure was modest. Policymakers need to ascertain the priority of lowering the burden of high-cost families’ out-of-pocket expenses through improving the reimbursement proportion and reducing avoidable medical services.