bluuebunny/crossref_metadata_2025_split huggingface dataset:
BIỂU HIỆN DẤU ẤN TẾ BÀO GỐC UNG THƯ CD44 TRONG UNG THƯ BIỂU MÔ TUYẾN ĐẠI TRỰC TRÀNG
Authors: Tiền Thanh Liêm 
Published: September 2024

Đặt vấn đề: Ung thư đại trực tràng là bệnh thường gặp đứng hàng thứ ba và tỷ lệ tử vong cao ở cả hai giới. Ở Việt Nam, ung thư đại trực tràng là loại ung thư phổ biến thứ năm tỷ lệ mắc bệnh ung thư. Nghiên cứu ứng dụng tế bào gốc ung thư làm dấu ấn để chẩn đoán và tiên lượng trong ung thư đại trực tràng đang là xu hướng nghiên cứu của bệnh lý này, trong đó có CD44, là dấu ấn tế bào gốc ung thư có liên quan đến sự phát triển, biệt hóa, khả năng sống còn của tế bào cũng như di căn của tế bào ung thư. Mục tiêu nghiên cứu: Nghiên cứu này nhằm mục đích khảo sát kiểu biểu hiện của CD44 trong biểu mô của bệnh ung thư đại trực tràng và xác định mối liên quan với các đặc điểm giải phẫu bệnh, giai đoạn bệnh Đối tượng và phương pháp nghiên cứu: Nghiên cứu cắt ngang bao gồm 102 mẫu ung thư đại trực tràng đủ tiêu chuẩn nghiên cứu và đủ tiêu chuẩn nhuộm hóa mô miễn dịch tại Bệnh viện 30-4 từ 2021 đến 2022. Tất cả các mẫu được nhuộm bằng kháng thể kháng CD44. Kiểu biểu hiện được đánh giá bằng 3 thang điểm của 03 tác giả khác nhau (Ribeiro, Tunugungtla và Gaber). Kết quả: biểu hiện CD44 dương tính chiếm tỷ lệ 70,6% theo thang điểm Ribeiro, và theo thang điểm Tunuguntla và Gaber, biểu hiện cao của CD44 lần lượt là 23,5% và 15,7%. Có mối liên quan có ý nghĩa thống kê giữa biểu hiện CD44 với với nhóm tuổi (p=0,021), hạch di căn (p=0,005), giai đoạn u (p=0,037), thời gian khởi bệnh (p= 0,036), thâm nhiễm chu vi đại tràng (p=0,034). Kết luận: Sự khác biệt của biểu hiện CD44 theo 3 thang điểm khác nhau có ý nghĩa thống kê. Có mối liên quan có ý nghĩa thống kê giữa biểu hiện CD44 với nhóm tuổi, hạch di căn, giai đoạn u (theo thang điểm Ribeiro); với thời gian khởi bệnh và thâm nhiễm chu vi đại tràng (theo thang điểm Tunuguntla)
American History Done Right
Authors: Moreau John Adam 
Published: September 2024

John Adam Moreau insists that in Wight Martindale Jr.’s American History from the Beginning to 1876: A Home School Guide, we finally have the appropriate rigor, balance, passion, and accessibility in an American history text for high school students: a sure antidote to the “boredom” and “indifference” resulting from standard textbook American “history by committee.”
HESS Opinions: Never train a Long Short-Term Memory (LSTM) network on a single basin
Authors: Kratzert Frederik , Gauch Martin , Klotz Daniel , Nearing Grey 
Published: September 2024

Abstract. Machine learning (ML) has played an increasing role in the hydrological sciences. In particular, Long Short-Term Memory (LSTM) networks are popular for rainfall–runoff modeling. A large majority of studies that use this type of model do not follow best practices, and there is one mistake in particular that is common: training deep learning models on small, homogeneous data sets, typically data from only a single hydrological basin. In this position paper, we show that LSTM rainfall–runoff models are best when trained with data from a large number of basins.
An Exploration of the Changing Reputation of Spring In A Small Town at Different Times
Authors: Bi Kaihui 
Published: September 2024

This article argues that while the power of political factors should not be underestimated, the change in the reputation of Fei Mu's Spring in a Small Town was a complex process that involved a combination of factors, such as the cultural construction of a symbolic system of the nation-state and the awakening of ontological consciousness brought about by economic development. More importantly, the study of audience reception of Spring in a Small Town has not been introduced in previous studies, and the lack of this perspective makes it impossible to grasp the complete journey of Chinese film conceptions and film viewing contexts. As Adorno argues, art is a product of social forces - economic, political, technological, etc. - and the proper study of art is the study of these forces. The fame of Spring in a Small Town has evolved from a controversial release in '48 to a classic of Chinese cinema today, providing a path to grasp the political, economic and cultural roles behind the film's critique and to understand the deep psychology of the audience at the time.
Unravelling Mortality in Enslavement. Patterns and Determinants of Mortality Among the Enslaved Population of Curaçao, 1839–1863
Authors: Metzlar Wieke Elien , Diepgrond Nadeche 
Published: September 2024

Examining demographic patterns of enslaved populations can shed light on living conditions of people living in slavery. During the 19th century, enslaved populations in Latin America and the Caribbean were characterized by an excess of deaths, indicating the harsh living conditions they were forced to live in. The island of Curaçao — at that time a Dutch colony — however, has formed an exception to this trend, as the enslaved population was characterized by natural increase. Today, newly crowdsourced data of the slave registers of Curaçao enables the examination of the entire enslaved population, which facilitates the study of (changes in) the demographic development on the island. This paper aims to gain insight into patterns of mortality between 1839 and 1863 in order to shed light on the determinants of the exceptional demographic development of the enslaved population of Curaçao. This research examines the mortality rates of the population and explores possible determinants — seasonality, sex and age — of this unique mortality pattern (n = 12,793). Previous research stressed the importance of the fertility pattern of Curaçao as the determinant in the natural increase of the population, however, the results showed that mortality might have played a more decisive role. The relatively low mortality rates allowed fertility rates to exceed, and so, this positive difference between birth and death resulted in a unique pattern of natural increase of an enslaved population in the Caribbean.
Effect of a smartphone self-management digital support system for low-back pain (selfBACK) among workers with high physical work demands – secondary analysis of a randomized controlled trial
Authors: Rasmussen Charlotte Diana Nørregaard , Sandal Louise Fleng , Holtermann Andreas , Stochkendahl Mette Jensen , Mork Paul Jarle , Søgaard Karen 
Published: September 2024

OBJECTIVE: This study aimed to investigate whether physical work demands modify the effect of the selfBACK app, which is designed to support self-management of low-back pain.
METHODS: In a secondary analysis of the selfBACK trial with 346 employed participants, we stratified into low (N=165) and high physical work demands (N=181). Outcomes included the Roland-Morris Disability Questionnaire (0–24), a numeric rating scale for low-back pain intensity (0–10), the Pain Self-Efficacy Questionnaire (0–60), and work ability (0–10). Intervention effects were assessed at three- and nine-month follow-ups using a linear mixed model.
RESULTS: At three months, high physical demand workers with selfBACK showed a significant reduction in pain intensity [-0.8, 95% confidence interval (CI) -1.3– -0.2] compared to usual care. By nine months, the high physical demands workers with selfBACK reported reduced pain-related disability (-1.4, 95% CI -2.7– -0.1), improved pain self-efficacy (3.5, 95% CI 0.9–6.0), and lower pain intensity (-1.0, 95% CI -1.6– -0.4) compared to usual care. Low physical demands workers with selfBACK also improved pain self-efficacy [2.8 (95% CI 0.3–5.3)] compared to usual care. The impact of selfBACK was more noticeable among workers with high physical demands compared to their low physical demand counterparts, but no statistically significant differences were found in any outcome.
CONCLUSIONS: The selfBACK intervention had consistent effects across workers with high and low physical work demands, indicating that these demands did not modify its impact. Both groups experienced similar positive effects, highlighting the intervention’s effectiveness across varying levels of physical work demands.
Lateral femoral neck stress fractures: A case report
Authors: Oudmaijer Christiaan AJ , Paulino Pereira Nuno R , Visser David , Wakker Alexander M , Veltman Wout S , van Linschoten Robbart 
Published: September 2024

BACKGROUND
Sport-induced injuries particularly affect young, healthy, and active individuals. Running, a popular and accessible sport, can cause a wide range of injuries, including stress fractures. Stress fractures can occur during high-intensity training or competitions, especially among well-trained amateurs and professional athletes. Adequate diagnosis can be complicated by the typically young age, unremarkable medical history, and vital condition of the patient. Stress fractures present insidiously, and this is specifically the case with stress fractures of the femoral neck. Timely intervention is crucial to prevent progressive displacement, as this can damage the blood supply to the femoral head.
CASE SUMMARY
A 30-year-old male runner presented to our outpatient clinic with persistent pain 3 weeks after running a marathon. X-ray showed a complete lateral fracture of the left femoral neck, which was treated surgically with a dynamic hip screw.
CONCLUSION
It is essential for healthcare providers to be vigilant for the subtle symptoms of stress fractures to ensure timely treatment. Early recognition prevents complication and leads to a better prognosis.
Pelatihan Uji Kuesioner Pada Mahasiswa Prodi Manajemen Fakultas Hukum Dan Bisnis Universitas Duta Bangsa Surakarta
Authors: Saryadi Saryadi  , Erma Nurhayati Firdaus  , Nisaa ‘Awalia  , Septiyanitha  Dwi Maharani Putri  
Published: September 2024

Program SPSS telah banyak digunakan dalam analisis data dalam suatu penelitian. Mitra kegiatan merupakan mahasiswa prodi Manajemen FHB–UDB Surakarta. Walaupun mahasiswa, bisa belajar teknik dalam penelitian, namun secara realita, banyak yang memahaminya. Materi pelatihan diberikan online. Oleh sebab itu perlu adanya pelatihan sebagai upaya memberi penguatan untuk pembelajaran. Kegiatan ini dengan sasaran para mahasiswa kelas 20A1 dan 20A2 dalam topik kegiatan pelatihan uji kualitas data dengan memanfaatkan IBM SPSS. Melalui kegiatan pelatihan ini lebih ditekankan untuk pemahaman dalam memperoleh nilai validitas dan reliabilitas, sehingga mitra lebih memahami untuk melakukan pengujian data dengan program IBM SPSS. Pemahaman ini diakui mitra pasca membandingkan pre test dengan post test melalui tanya jawab. Pelatihan ini dilakukan pasca dilakukannya penyuluhan dalam rangka memeperoleh nilai validitas dan reliabilitas dan mitra ikut aktif dalam kegiatan. Kegiatan pengabdian ini menjadi penguatan materi yang pernah dipelajari mitra.
O acesso à população trans na atenção primária em saúde para garantia dos direitos sexuais: revisão integrativa
Authors: Almeida Luciane Pereira de , Mouta Ricardo José Oliveira , Costa Cristiane Maria Amorim , Araujo Luciane Marques de , Peres Patrícia Lima Pereira , Santos Roberta Georgia Sousa dos , Chao William Santos 
Published: September 2024

Introdução: O texto aborda a importância da saúde sexual na atenção básica, especialmente para a população trans, tendo como objetivo analisar a produção científica dos desafios/dificuldades, demandas/necessidades da população trans na atenção básica para a garantia da equidade no acesso à saúde sexual. Metodologia: O estudo utilizou como proposta uma Revisão Integrativa (RI) com delimitação de recorte temporal de publicações referentes aos últimos cinco anos, assim como inclusão dos filtros: texto completo disponível em inglês, português e espanhol, nas bases MEDLINE / PUBMED, LILACS e BDENF, no CVSP, IBECS e na ColecionaSUS, utilizando os Descritores em Ciências da Saúde: “Saúde Sexual” AND “Serviços de Saúde para Pessoas Transgênero” AND “Atenção Primária à Saúde”. Resultados: Os artigos referentes à seleção dos estudos foram agrupados e apresentados através do PRISMA, onde 41 artigos encontrados, 14 foram excluídos e dos 27 elegíveis para leitura, apenas 7 atenderam aos critérios de inclusão para a revisão. Esses artigos destacam os desafios no acesso aos serviços de saúde, as demandas e necessidades específicas da população trans e propõem considerações para melhorar o atendimento e a assistência, visando um sistema de saúde mais inclusivo e equitativo. Discussão: Foram identificadas três categorias principais de obstáculos: (1) conduta/comportamento dos profissionais, que mostram não estarem preparados para lidar com questões de orientação sexual e identidade de gênero, resultando em falhas no acolhimento, discriminação e uso inadequado do nome social. Além disso, atitudes preconceituosas e falta de empatia comprometem a relação entre profissional e usuário, afastando a população LGBT dos serviços de saúde. No que tange às (2) políticas e gestão de saúde, a população trans enfrenta problemas na efetivação das políticas de saúde que aumentam as desigualdades no acesso. Essa (3) dificuldade na acessibilidade/equidade aos serviços, pode ser representado pelos entraves aos acessos a locais especializados, seja por uma falta de comunicação eficaz entre especialidades seja pelas barreiras geográficas e, o que leva muitas vezes a população trans a buscar tratamentos alternativos. Conclusão: as contribuições para melhorar o atendimento à população trans incluem a criação de ambientes clínicos acolhedores, a atualização dos protocolos e diretrizes clínicas, e a capacitação das equipes de saúde. Além disso, a revisão dos currículos educacionais dos profissionais de saúde para incluir as necessidades da comunidade LGBT é fundamental.
O Conselho Municipal dos Direitos da Criança e do Adolescente – CMDCA de Rio Claro - SP na perspectiva de uma política pública
Authors: Magri Vanessa Carneiro Bonina Lima 
Published: September 2024

No Brasil, com o advento da Constituição Federal de 1988, as crianças e adolescentes passaram a ser visualizados como sujeitos de direitos. Como consequência desta máxima, o Estatuto da Criança e do Adolescente, passou a viger a doutrina da proteção integral. O artigo em tela tem por objetivo evidenciar o Conselho Municipal dos Direitos da Criança e do Adolescente - CMDCA do município de Rio Claro - SP, na perspectiva de uma política pública de forma a questionar: As ações desenvolvidas pelo conselho em questão têm oportunizado a proteção integral às crianças moradoras do município de Rio Claro - SP? Temos como hipótese que tal política pública não consegue operacionalizar todos os contextos que fazem parte do ciclo de políticas expressas por Ball (2006), a saber: contexto de influência, contexto da produção de texto, contexto da prática, contexto dos resultados/efeitos e contexto de estratégia política. Metodologicamente trata-se de uma pesquisa qualitativa descritiva realizada mediante levantamento bibliográfico e documental. Como resultado, constata-se que o município de Rio Claro - SP cumpre com a prerrogativa legal de criação do CMDCA na perspectiva de uma política pública, contudo, não consegue ir além dos contextos de influência, contexto da produção de texto, contexto da prática ficando uma lacuna a ser preenchida que diz respeito aos contextos dos resultados/efeitos e contexto de estratégia política.
Effects of intraoperative fluid management on hemodynamics and tissue oxygenation according to the Pleth Variability Index in thoracic surgery
Authors: Savaser Semanur , Akdogan Ali , Erturk Engin , Kutanis Dilek , Gul Rauf , Sami Karapolat Bekir , Nur Kılıç Kubra 
Published: September 2024

Background: The aim of this study was to compare the total fluid volume performed by noninvasive Pleth Variability Index in thoracic surgery patients in comparison to conventional fluid management
Methods: In this prospective randomized controlled study conducted between May 2019 and May 2020, 80 patients (68 males, 12 females; mean age: 58.5±6.7 years; range, 18 to 65 years) were divided into two groups: control (Group C) and the Pleth Variability Index (Group P). After performing routine anesthesia and Pleth Variability Index monitoring for all patients, fluids were given at a rate of 2 mL/kg/h with the standard anesthesia technique. Additional fluid supplementation was provided based on hemodynamic data in Group C. In Group P, 250 mL bolus crystalloid fluid was provided when Pleth Variability Index was >14%. Mean arterial pressure, heart rate, oxygen saturation, arterial blood gas, and blood biochemistry were recorded. Total fluid volumes and urinary output were also recorded.
Results: There was no significant difference between the groups in terms of total fluid volumes or urinary output. In the postoperative period, the oxygen saturation and mean arterial pressure of Group P were found to be higher than those of Group C. The postoperative creatinine and lactate values of Group P were lower than those of Group C.
Conclusion: Although there was no significant difference in the total fluid given to the patients, fluid management by Pleth Variability Index monitoring had a positive effect on mean arterial pressure, oxygen saturation, lactate, and creatinine levels.
Sternal wound types after median sternotomy and reconstruction using dead space-based approach
Authors: Can Bilgen , Furkan Kırış Yusuf , Dağ Hatip , Çağrı Güzel Yunus , Dolapoğlu Ahmet 
Published: September 2024

Background: This study aims to classify wound complications after median sternotomy and provide an up-to-date reconstructive algorithm for multidisciplinary use.
Methods: A total of 15 patients (9 males, 6 females; mean age: 68±5 years; range, 60 to 75 years) who underwent sternal reconstruction for wound complications following median sternotomy between August 2020 and October 2023 were retrospectively analyzed. Wound complications requiring reconstruction were classified into three categories based on the extent of the dead space caused by sternal debridement. Type 1, 2, and 3 wounds presented with only skin defects and an intact sternum, with partial and total sternectomy, respectively. The time to consultation for plastic surgery and the duration of hospitalization were compared.
Results: Among the wounds, type 2 wounds were the most common type seen in 11 patients. Two patients each had type 1 and type 3 wounds. A superior epigastric artery perforator skin flap was used for type 1 wounds. Bilateral pectoral and split pectoral turnover muscle flaps from the side where the internal mammary artery was intact were used for type 2 wounds. A rectus abdominis muscle flap was used for type 3 wounds. Early consultation from plastic surgery reduced the length of hospital stay.
Conclusion: For type 1 wounds, skin flaps ensured sufficient coverage as they involved skin and subcutaneous fat, matching the defect. However, sternal excision required muscle flaps to fill the dead space, in which the vital organs were exposed.
Efforts to Treatment and Utilize Domestic Wastewater in the AMDK and Beverages Industry in East Java
Authors: Zevhianan Acbellita Ayu 
Published: September 2024

Industrial wastewater consists of produced wastewater and domestic wastewater. Industrial domestic wastewater comes from the sanitation activities of workers and supporting facilities such as canteens, mosques, and prayer rooms that must be treated so as not to pollute the environment. The industry in the case study engaged in the Bottled Drinking Water (AMDK) and Beverages Industry has tried to treat and even utilize 100% of its domestic wastewater. Processing is carried out through the Sewage Treatment Plant (STP) facility with a biological process capable of removing BOD; COD; TSS; Oils & Fats; Ammonia; Total Coliform; Fecal Coliform; and Residual Chlorine parameters by 95%; 98%; 36%; 95%; 99%; 97,8%; 97,8; and 99% and has been below the quality standard. The percentage of pH and TSS removal is quite low because the influent measurement is still below the quality standard, so processing is focused on lowering organic parameters which are quite high. After treatment, wastewater is reused 100% for watering and washing. Domestic wastewater utilization of AMDK and Beverages Industry can reduce the use of clean water for RTH watering by up to 74%, and the rest is used for hydrants and sprinkler reservoirs.
Studi Penggunaan Limbah Kardus Sebagai Subtitusi Agregat Halus Dengan Menggunakan Zat Additive Superplasticizer Pada Material Lightweight Concrete
Authors: Rini Nanda Puspita , Santoso Toni Budi , Zainuddin  
Published: September 2024

Sistem Informasi Pengelolaan Sampah Nasional (SIPSN) menginformasikan bahwa banyaknya limbah kardus pada tahun 2023 mencapai 11,06% dari total sampah 18.414.659 ton. Dikarenakan hal tersebut, pemanfaatan limbah kardus dalam campuran penyusun beton menjadi salah satu pilihan untuk mengatasi masalah pembuangan limbah kardus. Metode dalam penelitian ini yaitu eksperimental dengan berpedoman pada SNI 03-3449-2002 tentang Pedoman Perancangan Campuran Beton Ringan Menggunakan Agregat Ringan. Berdasarkan hasil dari penelitian yang telah dilaksanakan diperoleh hasil rata-rata kekuatan tekan pada umur 21 hari pada variasi normal 12,18 Mpa, variasi normal +sp 11,41 Mpa, variasi 2,5% 6,15 Mpa, dan variasi 5% 7,18 Mpa. Sedangkan pada umur 28 hari diperoleh pada variasi normal 12,50 Mpa, variasi normal +sp 12,30 Mpa, variasi 2,5% 6,98 Mpa, dan variasi 5% 7,24 Mpa. Berdasarkan hasil perhitungan kuat tekan dalam setiap variasi mengalami peningkatan nilai kuat tekan yaitu pada variasi normal terjadi peningkatan sebesar 2,62% dari umur 21 ke 28 hari, untuk variasi normal + SP mengalami peningkatan sebesar 7,8% dari umur 21 ke 28 hari, pada variasi campuran limbah kardus 2,5% terjadi peningkatan sebesar 11,89% dari umur 21 ke 28 hari, dan pada variasi campuran limbah kardus 5% terjadi peningkatan sebesar 0,83% dari umur 21 ke 28 hari. Dari perolehan hasil uji kekuatan tekan beton dapat disimpulkan bahwa benda uji menggunakan subtitusi limbah kardus terhadap agregat halus pada beton ringan mempengaruhi kekuatan tekan beton, akan tetapi tidak menambah perkuatan pada beton ringan.
Kata kunci: bubur kardus, batu apung, superplasticizer, beton ringan, kuat tekan beton
Principles of Veterinary Community Engagement
Authors: Watson Brittany , Berliner Elizabeth , DeTar Lena , McCobb Emily , Frahm-Gilles William , Henry Erin , King Erin , Powell Lauren , Reinhard Chelsea , Stavisky Jenny 
Published: September 2024

These Principles of Veterinary Community Engagement are closely adapted from the 2nd Edition of the Principles of Community Engagement, published by a coalition of human health agencies to guide human healthcare programs. This publication echoes their original nine principles but has been reorganized and refined to focus on programs providing healthcare services to animals.
When engaging with the animals and families in marginalized, underserved, or underrepresented communities, the veterinary medical field has opportunities and responsibilities. Project volunteers are often excited and passionate, and if guided well, their efforts can have significant impacts for people and their animals. Unfortunately, good intentions do not guarantee positive outcomes. The goal of the document is to enhance understanding of the challenges in designing, implementing, and sustaining VCE programs, and to ensure the dignity, health, and welfare of animals and the communities caring for them.
Our field has an obligation to identify and follow evidence-based ethical engagement practices refined through decades of research from human health engagement programs. As VCE continues to gain momentum in academic and research settings, the public sector, philanthropic organizations, and veterinary student training programs, formal guidelines for such engagement have become necessary.