bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gorham-Stout Disease Management during Pregnancy
Authors: Bargagli Elena , Piccioli Caterina , Cavigli Edoardo , Scola Marianna , Rosi Elisabetta , Lavorini Federico , Novelli Luca , Ugolini Dario , Notaristefano Tommaso , Filippo Pieralli , Miele Vittorio , Comin Camilla , Pistolesi Massimo , Voltolini Luca 
Published: December 2017

AbstractGorham-Stout Disease (GSD) is a rare lymphatic disorder affecting children or young adults with no predilection of sex. It is generally associated with vanishing bone osteolytic lesions, thoracic and abdominal involvement, and diffuse pulmonary lymphangiomatosis. Chylous effusions and chylothorax, consequent to the abnormal proliferation of lymphatic vessels, may induce respiratory failure with a high mortality risk. Extrapulmonary alterations may include chylous ascites, lymphopenia, and destructing bone disease for overgrowth of lymphatic vessels. Here, we report the case of a young woman who developed a severe and recalcitrant GSD with persistent unilateral chylothorax during pregnancy. The complex management of this patient during and after pregnancy was discussed and compared with literature data to contribute to the definition of a correct diagnostic and therapeutic approach to this rare lymphatic disease.
Postoperative Bildgebung nach Gelenkersatz – Knie, Hüfte, Schulter
Authors: Saupe Nadja , Romero Jose , Hersche Otmar , Zanetti Marco 
Published: December 2017

ZusammenfassungDie Gelenke an Knie, Hüfte und Schulter werden häufig und mit gutem Erfolg ersetzt. Mit der weiteren Zunahme dieser Operationen wächst auch die Bedeutung der postoperativen Bildgebung. Besonders Röntgen und CT werden für Routinekontrollen und zum Nachweis von Komplikationen eingesetzt. Die MRT kann – fortgeschrittene Techniken zur Reduktion von Metallartefakten vorausgesetzt – die um die Prothese liegenden Weichteile am besten darstellen.
Neurohormonelle Stressregulation
Authors: Schmidt Karlheiz , Bayer Wolfgang 
Published: December 2017

ZusammenfassungNervensystem und Hormonsystem sind neben dem Immunsystem die wichtigsten Kommunikationsnetzwerke im
menschlichen Organismus. Alle 3 Systeme stehen in ständiger Wechselwirkung, wobei das Hormonsystem in
aller Regel auch die Mitwirkung des Gefäßsystems erfordert.
Der emotionsgeplagte Magen
Authors: Hertling Bernd 
Published: December 2017

SummaryPsychosomatische Symptome zeigen sich besonders häufig im Bereich des Magens, wo sie gerne als Gastritis fehlgedeutet werden. Neben einer Lebensstiländerung und Rhythmisierung des Alltags bieten sich traditionelle Heilpflanzen wie Kamille, Melisse, Löffelkraut, Brunnenkresse und Braunwurz an. Sowohl spagyrische als auch phytotherapeutische Zubereitungen haben sich in der Praxis bewährt.
Effects of mutation and selection on plasticity of a promoter activity in
Saccharomyces cerevisiae
Authors: Duveau Fabien , Yuan David C. , Metzger Brian P. H. , Hodgins-Davis Andrea , Wittkopp Patricia J. 
Published: December 2017

Significance
From seasonal variation in the color of butterfly wings to trees bending toward the light, organisms often change in response to their environment. These changes, known as phenotypic plasticity, can result from differences in how genes are expressed among environments. Mutations causing environment-specific changes in gene expression provide raw material for phenotypic plasticity, but their frequency, effect size, and direction of effects among environments are not well understood. This study shows that mutations in the promoter of a yeast metabolic gene often display environment-dependent effects on gene expression and that these environment-dependent effects have been shaped by selection in natural populations.
Managing the transition to open access publishing: a psychological perspective
Authors: Weckowska Dagmara M. , Levin Nadine , Leonelli Sabina , Dupré John , Castle David 
Published: December 2017

Abstract
To manage the transition to the open access (OA) model of scholarly publishing, we need to understand better what enables, encourages and inhibits the adoption of OA publishing among scientists, and to appreciate individual differences within disciplines. The study adopts a psychological perspective to elucidate motivations, capabilities and opportunities for OA publishing among bioscientists in the UK. To identify differences within the discipline, bioscientists with starkly different past practices for disclosing research data and technologies were interviewed. The sampled bioscientists face similar obstacles and enablers in their physical environment, but that their motivations and experience of their social environments differ. One group is strongly motivated by their moral convictions and beliefs in benefits of OA and feels peer pressure related to OA. The other group expresses fewer pro-OA beliefs, holds beliefs demotivating OA publishing, but feels pressure from research funders to adopt it. The former group makes more frequent use of OA publishing, which suggests that only those with strong motivations will work to overcome the social and physical obstacles. The individual differences within the discipline suggest that bioscientists are unlikely to respond to OA policies in the same way and, thus, the appropriateness of one-size-fits-all OA policies is questioned.
Interactions of toroidally coupled tearing modes in the KSTAR tokamak
Authors: Kim Gnan , Yun Gunsu S , Woo Minho , Park Hyeon K 
Published: December 2017

Abstract
The evolutions of toroidally coupled radially-distant and radially-adjacent tearing modes are visualized in 2D in detail on the Korea superconducting tokamak for advanced research. The coupled tearing modes are in-phase on the out-board mid-plane and become destabilized or compete with each other depending on their spatial separation. When two coupled tearing modes are far apart, both are increasingly destabilized. On the other hand, when they become close to each other, one becomes stabilized while the other becomes destabilized. In such cases, an additional tearing mode is often formed on outer rational flux surface and the three tearing modes compete. The competitions suggest that spatial overlap (merging) of coupled magnetic islands is difficult.
RETRACTED: Analysis on the University’s Network Security Level System in the Big Data Era
Authors: Li Tianli 
Published: December 2017

Abstract
The rapid development of science and technology, the continuous expansion of the scope of computer network applications, has gradually improved the social productive forces, has had a positive impact on the increase production efficiency and industrial scale of China's different industries. Combined with the actual application of computer network in the era of large data, we can see the existence of influencing factors such as network virus, hacker and other attack modes, threatening network security and posing a potential threat to the safe use of computer network in colleges and universities. In view of this unfavorable development situation, universities need to pay attention to the analysis of the situation of large data age, combined with the requirements of network security use, to build a reliable network space security system from the equipment, systems, data and other different levels. To avoid the security risks exist in the network. Based on this, this paper will analyze the hierarchical security system of cyberspace security in the era of large data.
A β-Glucan-Based Dietary Fiber Reduces Mast Cell-Induced Hyperpermeability in Ileum From Patients With Crohn’s Disease and Control Subjects
Authors: Ganda Mall John-Peter , Casado-Bedmar Maite , Winberg Martin E , Brummer Robert J , Schoultz Ida , Keita Åsa V 
Published: December 2017

Abstract

Background
Administration of β-glucan has shown immune-enhancing effects. Our aim was to investigate whether β-glucan could attenuate mast cell (MC)-induced hyperpermeability in follicle-associated epithelium (FAE) and villus epithelium (VE) of patients with Crohn’s disease (CD) and in noninflammatory bowel disease (IBD)-controls. Further, we studied mechanisms of β-glucan uptake and effects on MCs in vitro.

Methods
Segments of FAE and VE from 8 CD patients and 9 controls were mounted in Ussing chambers. Effects of the MC-degranulator compound 48/80 (C48/80) and yeast-derived β-1,3/1,6 glucan on hyperpermeability were investigated. Translocation of β-glucan and colocalization with immune cells were studied by immunofluorescence. Caco-2-cl1- and FAE-cultures were used to investigate β-glucan-uptake using endocytosis inhibitors and HMC-1.1 to study effects on MCs.

Results
β-glucan significantly attenuated MC-induced paracellular hyperpermeability in CD and controls. Transcellular hyperpermeability was only significantly attenuated in VE. Baseline paracellular permeability was higher in FAE than VE in both groups, P&lt;0.05, and exhibited a more pronounced effect by C48/80 and β-glucan P&lt;0.05. No difference was observed between CD and controls. In vitro studies showed increased passage, P&lt;0.05, of β-glucan through FAE-culture compared to Caco-2-cl1. Passage was mildly attenuated by the inhibitor methyl-β-cyclodextrin. HMC-1.1 experiments showed a trend to decreasing MC-degranulation and levels of TNF-α but not IL-6 by β-glucan. Immunofluorescence revealed more β-glucan-uptake and higher percentage of macrophages and dendritic cells close to β-glucan in VE of CD compared to controls.

Conclusions
We demonstrated beneficial effects of β-glucan on intestinal barrier function and increased β-glucan-passage through FAE model. Our results provide important and novel knowledge on possible applications of β-glucan in health disorders and diseases characterized by intestinal barrier dysfunction.
Dietary Patterns in women with Inflammatory Bowel Disease and Risk of Adverse Pregnancy Outcomes: Results from The Norwegian Mother and Child Cohort Study (MoBa)
Authors: Myklebust-Hansen Thea , Aamodt Geir , Haugen Margaretha , Brantsæter Anne Lise , Vatn Morten H , Bengtson May-Bente 
Published: December 2017

Abstract

Background
The aim of the study was to examine dietary patterns and risk of adverse pregnancy outcomes among mothers with inflammatory bowel disease (IBD) in the Norwegian Mother and Child Cohort Study (MoBa).

Method
MoBa enrolled participants from all over Norway between 1999 and 2008, and the study comprised 83,988 mothers, of whom there were 183 mothers with Crohn’s disease (CD) and 240 with ulcerative colitis (UC). An additional questionnaire was submitted to mothers with IBD in 2013. We extracted three exploratory dietary patterns: a “Prudent,” a “Western,” and a “Traditional” pattern. We explored the relationship between dietary patterns and IBD and dietary patterns and adverse pregnancy outcomes: small for gestational age (SGA) and preterm delivery (PTD).

Results
IBD mothers had a significantly lower adherence to the Traditional dietary pattern [mean score -0.10 (95% CI: - 0.2 - - 0.01)] than non-IBD mothers. In IBD mothers, middle and high adherence to the Traditional dietary pattern was associated with lower risk of SGA [OR tertile 2 vs. tertile 1: 0.44 (95% CI: 0.20 - 0.97) and OR tertile 3 vs. tertile 1: 0.23 (95% CI: 0.08–0.61)] than in IBD and non-IBD mothers with low adherence. In the IBD-subset analyses, similar results were demonstrated for UC mothers [OR tertile 2 vs. tertile 1: 0.21 (95% CI: 0.05 – 0.80) and OR tertile 3 vs. tertile 1: 0.16 (95% CI: 0.04 – 0.60)].

Conclusion
In IBD mothers, higher adherence to a Traditional dietary pattern, characterized by high consumption of lean fish, fish products, potatoes, rice porridge, cooked vegetables, and gravy, was associated with lower risk of SGA.
Separation of Dual Oxidase 2 and Lactoperoxidase Expression in Intestinal Crypts and Species Differences May Limit Hydrogen Peroxide Scavenging During Mucosal Healing in Mice and Humans
Authors: Rigoni Alice , Poulsom Richard , Jeffery Rosemary , Mehta Shameer , Lewis Amy , Yau Christopher , Giannoulatou Eleni , Feakins Roger , Lindsay James O , Colombo Mario P , Silver Andrew 
Published: December 2017

Abstract

Background
DUOX2 and DUOXA2 form the predominant H2O2-producing system in human colorectal mucosa. Inflammation, hypoxia, and 5-aminosalicylic acid increase H2O2 production, supporting innate defense and mucosal healing. Thiocyanate reacts with H2O2 in the presence of lactoperoxidase (LPO) to form hypothiocyanate (OSCN-), which acts as a biocide and H2O2 scavenging system to reduce damage during inflammation. We aimed to discover the organization of Duox2, Duoxa2, and Lpo expression in colonic crypts of Lieberkühn (intestinal glands) of mice and how distributions respond to dextran sodium sulfate (DSS)-induced colitis and subsequent mucosal regeneration.

Methods
We studied tissue from DSS-exposed mice and human biopsies using in situ hybridization, reverse transcription quantitative polymerase chain reaction, and cDNA microarray analysis.

Results
Duox2 mRNA expression was mostly in the upper crypt quintile while Duoxa2 was more apically focused. Most Lpo mRNA was in the basal quintile, where stem cells reside. Duox2 and Duoxa2 mRNA were increased during the induction and resolution of DSS colitis, while Lpo expression did not increase during the acute phase. Patterns of Lpo expression differed from Duox2 in normal, inflamed, and regenerative mouse crypts (P &lt; 0.001). We found no evidence of LPO expression in the human gut.

Conclusions
The spatial and temporal separation of H2O2-consuming and -producing enzymes enables a thiocyanate- H2O2 “scavenging” system in murine intestinal crypts to protect the stem/proliferative zones from DNA damage, while still supporting higher H2O2 concentrations apically to aid mucosal healing. The absence of LPO expression in the human gut suggests an alternative mechanism or less protection from DNA damage during H2O2-driven mucosal healing.
The Multiple-Patient Simulation Toolkit: Purpose, Process, and Pilot
Authors: Beroz Sabrina , Sullivan Nancy , Kramasz Vanessa , Morgan Patricia 
Published: December 2017

Abstract
Educating nursing students to safely care for multiple patients has become an important but challenging focus for nurse educators. New graduate nurses are expected to manage care for multiple patients in a complex and multifaceted health care system. With patient safety as a priority, multiple-patient assignments are necessary in order for nursing students to learn how to effectively prioritize and delegate care. The purpose of this project was the construction of an adaptable and flexible template for the development of multiple-patient simulations. Through utilization, the template moved to a toolkit adding an operational guide, sample-populated template, and bibliography.
Exploring Truth, Justice, Compassion, Community, and Partnership While Learning to Care for Veterans Through Study, Reflection, and Action
Authors: Crary Pamela 
Published: December 2017

Abstract
This article describes an innovative elective nursing course developed and implemented in a private, liberal arts school of nursing grounded in Dominican values of study, reflection, and action. Course development, course content, and highlights and lowlights of the first cohort experience and implications for the community are discussed, along with background about veteran-centered care.
Critical Care Organizations: Building and Integrating Academic Programs
Authors: Moore Jason E. , Oropello John M. , Stoltzfus Daniel , Masur Henry , Coopersmith Craig M. , Nates Joseph , Doig Christopher , Christman John , Hite R. Duncan , Angus Derek C. , Pastores Stephen M. , Kvetan Vladimir 
Published: December 2017

Objective:
Academic medical centers in North America are expanding their missions from the traditional triad of patient care, research, and education to include the broader issue of healthcare delivery improvement. In recent years, integrated Critical Care Organizations have developed within academic centers to better meet the challenges of this broadening mission. The goal of this article was to provide interested administrators and intensivists with the proper resources, lines of communication, and organizational approach to accomplish integration and Critical Care Organization formation effectively.

Design:
The Academic Critical Care Organization Building section workgroup of the taskforce established regular monthly conference calls to reach consensus on the development of a toolkit utilizing methods proven to advance the development of their own academic Critical Care Organizations. Relevant medical literature was reviewed by literature search. Materials from federal agencies and other national organizations were accessed through the Internet.

Setting:
The Society of Critical Care Medicine convened a taskforce entitled “Academic Leaders in Critical Care Medicine” on February 22, 2016 at the 45th Critical Care Congress using the expertise of successful leaders of advanced governance Critical Care Organizations in North America to develop a toolkit for advancing Critical Care Organizations.

Measurements and Main Results:
Key elements of an academic Critical Care Organization are outlined. The vital missions of multidisciplinary patient care, safety, and quality are linked to the research, education, and professional development missions that enhance the value of such organizations. Core features, benefits, barriers, and recommendations for integration of academic programs within Critical Care Organizations are described. Selected readings and resources to successfully implement the recommendations are provided. Communication with medical school and hospital leadership is discussed.

Conclusions:
We present the rationale for critical care programs to transition to integrated Critical Care Organizations within academic medical centers and provide recommendations and resources to facilitate this transition and foster Critical Care Organization effectiveness and future success.
APPLICATION OF OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY TO ASSESS ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR THERAPY IN MYOPIC CHOROIDAL NEOVASCULARIZATION
Authors: Cheng Ying , Li Ying , Huang Xin , Qu Yi 
Published: December 2017

Purpose:
Using optical coherence tomography (OCT) angiography to assess the therapeutic effect of intravitreal anti–vascular endothelial growth factor on myopic choroidal neovascularization (CNV) by detecting the changes of shape, size, and flow area.

Methods:
Our prospective case series recruited consecutive patients with myopic CNV from January 2016 to August 2016. Intravitreal injections of ranibizumab were conducted on all patients. Patients received OCT angiography on 3 different follow-ups, including before treatment, 1 week after treatment, and 1 month after treatment. At each visit, we measured the best-corrected visual acuity, central macular thickness , greatest linear dimension of CNV, selected CNV area and flow area using OCT angiography.

Results:
This study involved 13 eyes of 12 patients, in which 9 eyes were of 9 women and 4 eyes were of 3 men, with mean age of 49.92 ± 14.79 years. Best-corrected visual acuity was significantly improved with decreased central macular thickness, greatest linear dimension, intraretinal fluid, or subretinal fluid 7 days or 30 days after treatment (All P < 0.05). Myopic CNV was presented as irregular or nearly round closed mass at the level of the outer retinal layer in all eyes at the initial visit. Thirty days after treatment, the size of selected CNV area and flow area were further decreased (t = 4.012, P = 0.003).

Conclusion:
Combined with OCT B-scan, OCT angiography, a new technique, could provide sensitive and intuitive images and quantitative analysis for monitoring and evaluating the therapeutic effect of intravitreal anti–vascular endothelial growth factor for myopic CNV.
Novel Image-Based Analysis for Reduction of Clinician-Dependent Variability in Measurement of the Corneal Ulcer Size
Authors: Patel Tapan P. , Prajna N Venkatesh , Farsiu Sina , Valikodath Nita G. , Niziol Leslie M. , Dudeja Lakshey , Kim Kyeong Hwan , Woodward Maria A. 
Published: December 2017

Purpose:
To assess variability in corneal ulcer measurements between ophthalmologists and reduce clinician-dependent variability using semiautomated segmentation of the ulcer from photographs.

Methods:
Three ophthalmologists measured 50 patients' eyes for epithelial defects (EDs) and the stromal infiltrate (SI) size using slit-lamp (SL) calipers. SL photographs were obtained. An algorithm was developed for semiautomatic segmenting of the ED and SI in the photographs. Semiautomatic segmentation was repeated 3 times by different users (2 ophthalmologists and 1 trainee). Clinically significant variability was assessed with intraclass correlation coefficients (ICCs) and the percentage of pairwise measurements differing by ≥0.5 mm. Semiautomatic segmentation measurements were compared with manual delineation of the image by a corneal specialist (gold standard) using Dice similarity coefficients.

Results:
Ophthalmologists' reliability in measurements by SL calipers had an ICC from 0.84 to 0.88 between examiners. Measurements by semiautomatic segmentation had an ICC from 0.96 to 0.98. SL measures of ulcers by clinical versus semiautomatic segmentation measures differed by ≥0.5 mm in 24% to 38% versus 8% to 28% (ED height); 30% to 52% versus 12% to 34% (ED width); 26% to 38% versus 10% to 32% (SI height); and 38% to 58% versus 14% to 34% (SI width), respectively. Average Dice similarity coefficients between manual and repeated semiautomatic segmentation ranged from 0.83 to 0.86 for the ED and 0.78 to 0.83 for the SI.

Conclusions:
Variability exists when measuring corneal ulcers, even among ophthalmologists. Photography and computerized methods for quantifying the ulcer size could reduce variability while remaining accurate and impact quantitative measurement endpoints.
Unilateral Posterior Interstitial Keratitis as a Clinical Presentation of Herpes Simplex Virus Disease
Authors: Farooq Asim V. , Paley Grace L. , Lubniewski Anthony J. , Gonzales John A. , Margolis Todd P. 
Published: December 2017

Purpose:
To describe a case series of patients with unilateral, posterior interstitial keratitis presumed to be caused by herpes simplex virus.

Methods:
Retrospective case series.

Results:
Five patients were found to have unilateral, posterior interstitial keratitis. Three of the involved eyes had decreased corneal sensation, and 2 eyes had corneal stromal neovascularization. All patients were treated with topical steroids and an oral antiviral, and among those with long-term follow-up, clinical improvement required treatment over an extended duration. A review of the literature revealed 1 reported case with a similar clinical appearance, although that case was attributed to Lyme disease.

Conclusions:
The clinical presentation of unilateral, posterior interstitial keratitis may be a rare manifestation of herpes simplex virus keratitis.