bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adverse Event Reporting: Harnessing Residents to Improve Patient Safety
Authors: Tevis Sarah E. , Schmocker Ryan K. , Wetterneck Tosha B. 
Published: October 2017

Objectives
Reporting of adverse and near miss events are essential to identify system level targets to improve patient safety. Resident physicians historically report few events despite their role as front-line patient care providers. We sought to evaluate barriers to adverse event reporting in an effort to improve reporting. Our main outcomes were as follows: resident attitudes about event reporting and the frequency of event reporting before and after interventions to address reporting barriers.

Methods
We surveyed first year residents regarding barriers to adverse event reporting and used this input to construct a fishbone diagram listing barriers to reporting. Barriers were addressed, and resident event reporting was compared before and after efforts were made to reduce obstacles to reporting.

Results
First year residents (97%) recognized the importance of submitting event reports; however, the majority (85%) had not submitted an event report in the first 6 months of residency. Only 7% of residents specified that they had not witnessed an adverse event in 6 months, whereas one third had witnessed 10 or more events. The main barriers were as follows: lack of knowledge about how to submit events (38%) and lack of time to submit reports (35%). After improving resident education around event reporting and simplifying the reporting process, resident event reporting increased 230% (68 to 154 annual reports, P = 0.025).

Conclusions
We were able to significantly increase resident event reporting by educating residents about adverse events and near misses and addressing the primary barriers to event reporting. Moving forward, we will continue annual resident education about patient safety, focus on improving feedback to residents who submit reports, and empower senior residents to act as role models to junior residents in patient safety initiatives.
Efficient genome editing in primary cells andin vivousing viral-derived “Nanoblades” loaded with Cas9/sgRNA ribonucleoproteins
Authors: Mangeot Philippe E. , Risson Valérie , Fusil Floriane , Marnef Aline , Laurent Emilie , Blin Juliana , Mournetas Virginie , Massouridès Emmanuelle , Sohier Thibault J. M. , Corbin Antoine , Aube Fabien , Pinset Christian , Schaeffer Laurent , Legube Gaëlle , Cosset François-Loïc , Verhoeyen Els , Ohlmann Théophile , Ricci Emiliano P. 
Published: October 2017

AbstractProgrammable nucleases have enabled rapid and accessible genome engineering in eukaryotic cells and living organisms. However, their delivery into target cells can be technically challenging when working with primary cells orin vivo. Using engineered murine leukemia virus-like particles loaded with Cas9/sgRNA ribonucleoproteins (“Nanoblades”), we were able to induce efficient genome-editing in cell lines and primary cells including human induced pluripotent stem cells, human hematopoietic stem cells and mouse bone-marrow cells. Transgene-free Nanoblades were also capable ofin vivogenome-editing in mouse embryos and in the liver of injected mice. Nanoblades can be complexed with donor DNA for “all-in-one” homology-directed repair or programmed with modified Cas9 variants to mediate transcriptional up-regulation of target genes. Nanoblades preparation process is simple, relatively inexpensive and can be easily implemented in any laboratory equipped for cellular biology.
LIN28 selectively modulates a subclass of let-7 microRNAs
Authors: Ustianenko Dmytro , Chiu Hua-Sheng , Weyn-Vanhentenryck Sebastien M. , Sumazin Pavel , Zhang Chaolin 
Published: October 2017

AbstractLIN28 is a bipartite RNA-binding protein that post-transcriptionally inhibits let-7 microRNAs to regulate development and influence disease states. However, the mechanisms of let-7 suppression remains poorly understood, because LIN28 recognition depends on coordinated targeting by both the zinc knuckle domain (ZKD)—which binds a GGAG-like element in the precursor—and the cold shock domain (CSD), whose binding sites have not been systematically characterized. By leveraging single-nucleotide-resolution mapping of LIN28 binding sitesin vivo, we determined that the CSD recognizes a (U)GAU motif. This motif partitions the let-7 family into Class I precursors with both CSD and ZKD binding sites and Class II precursors with ZKD but no CSD binding sites. LIN28in vivorecognition—and subsequent 3′ uridylation and degradation—of Class I precursors is more efficient, leading to their stronger suppression in LIN28-activated cells and cancers. Thus, CSD binding sites amplify the effects of the LIN28 activation with potential implication in development and cancer.
Anxiety-like but not despair-like behaviors are further aggravated by chronic mild stress in the early stages of APPswe/PS1dE9 transgenic mice
Authors: Gao Jun-Ying , Chen Ying , Su Dong-Yuan , Marshall Charles , Xiao Ming 
Published: October 2017

ABSTRACTEarly Alzheimer’s disease (AD) and depression share many symptoms, thus it is very difficult to initially distinguish one from the other. Therefore, characterizing the shared and different biological changes between the two disorders will be helpful in making an early diagnosis and planning treatment. In the present study, 8-week-old APPswe/PS1dE9 transgenic mice received chronic mild stress (CMS) for 8 weeks followed by a series of behavioral, biochemical and pathological analyses. APPswe/PS1dE9 mice demonstrated despair- and anxiety-like behaviors, and reduced sociability, accompanied by high levels of soluble beta-amyloid, glial activation, neuroinflammation and brain derived neurotrophic factor signaling disturbance in the hippocampus. Notably, APPswe/PS1dE9 mice exposure to CMS further aggravated anxiety-like behaviors rather than hopelessness and sociability deficits, accompanied with more severe neuroinflammation, and low serum corticosterone increased to the normal level. These results may help to understand the pathogenic mechanism of psychiatric symptoms associated with early AD.
A cell-free synthetic biochemistry platform for raspberry ketone production
Authors: Moore Simon J , Tosi Tomasso , Bell David , Hleba Yonek B , Polizzi Karen M , Freemont Paul S 
Published: October 2017

AbstractCell-free synthetic biochemistry provides a green solution to replace traditional petroleum or agricultural based methods for production of fine chemicals. 4-(4-hydroxyphenyl)-butan-2-one, also known as raspberry ketone, is the major fragrance component of raspberry fruit and is utilised as a natural additive in the food and sports industry. Current industrial processing standards involve chemical extraction with a yield of 1-4 mg per kilo of fruit. As such its market price can fluctuate up to $20,000 per kg. Metabolic engineering approaches to synthesise this molecule by microbial fermentation have only resulted in low yields of up to 5 mg L−1. In contrast, cell-free synthetic biochemistry offers an intriguing compromise to the engineering constraints provided by the living cell. Using purified enzymes or a two-step semisynthetic route, an optimised pathway was formed for raspberry ketone synthesis leading up to 100% yield conversion. The semi-synthetic route is potentially scalable and cost-efficient for industrial synthesis of raspberry ketone.
Across-subjects classification of stimulus modality from human MEG high frequency activity
Authors: Westner Britta U. , Dalal Sarang S. , Hanslmayr Simon , Staudigl Tobias 
Published: October 2017

AbstractSingle-trial analyses have the potential to uncover meaningful brain dynamics that are obscured when averaging across trials. However, low signal-to-noise ratio (SNR) can impede the use of single-trial analyses and decoding methods. In this study, we investigate the applicability of a single-trial approach to decode stimulus modality from magnetoencephalography (MEG) high frequency activity. In order to classify the auditory versus visual presentation of words, we combine beamformer source reconstruction with the random forest classification method. To enable group level inference, the classification is embedded in an across-subjects framework.We show that single-trial gamma SNR allows for good classification performance (accuracy across subjects: 66.44 %). This implies that the characteristics of high frequency activity have a high consistency across trials and subjects. The random forest classifier assigned informational value to activity in both auditory and visual cortex with high spatial specificity. Across time, gamma power was most informative during stimulus presentation. Among all frequency bands, the 75-95 Hz band was the most informative frequency band in visual as well as in auditory areas. Especially in visual areas, a broad range of gamma frequencies (55-125 Hz) contributed to the successful classification.Thus, we demonstrate the feasibility of single-trial approaches for decoding the stimulus modality across subjects from high frequency activity and describe the discriminative gamma activity in time, frequency, and space.Author SummaryAveraging brain activity across trials is a powerful way to increase signal-to-noise ratio in MEG data. This approach, however, potentially obscures meaningful brain dynamics that unfold on the single-trial level. Single-trial analyses have been successfully applied to time domain or low frequency oscillatory activity; its application to MEG high frequency activity is hindered by the low amplitude of these signals. In the present study, we show that stimulus modality (visual versus auditory presentation of words) can successfully be decoded from single-trial MEG high frequency activity by combining source reconstruction with a random forest classification algorithm. This approach reveals patterns of activity above 75 Hz in both visual and auditory cortex, highlighting the importance of high frequency activity for the processing of domain-specific stimuli. Thereby, our results extend prior findings by revealing high-frequency activity in auditory cortex related to auditory word stimuli in MEG data. The adopted across-subjects framework furthermore suggests a high inter-individual consistency in the high frequency activity patterns.
A grey-based decision-making approach to the supplier selection problem in a steelmaking company
Authors: Abdulshahed Ali M. , Badi Ibrahim A. , Blaow Mohamed Mehemed 
Published: October 2017

Purpose
The purpose of this paper is to propose a supplier selection method using grey system theory for a steelmaking company in Libya.

Design/methodology/approach
In order to tackle incompleteness and imprecision of human’s judgments, grey numbers were used. This work uses a grey-based approach to represent decision makers’ comparison judgments and extent analysis method to select the best supplier. Therefore, an example of a selection problem of a steelmaking company in Libya was used to illustrate the proposed approach.

Findings
Supplier selection in a supply chain is a critical strategic decision for company’s success and has attracted much attention of both academic scholars and decision makers. The authors have found that the Grey model can play an important role in improving supplier selection strategy, especially when it is in a situation where complex sustainability environments (i.e. Libya) exist.

Originality/value
No literature has been found till date for selection of supplier using grey system theory in a steelmaking company in Libya. An attempt in this regard could enhance a decision-making technique for selecting the best suppliers for the selected case company.
Improved GM(1, 1) model based on concave sequences and its applications
Authors: Kong Xinhai , Zhang Peng , Ma Xin 
Published: October 2017

Purpose
The purpose of this paper is to improve the GM(1, 1) model based on concave sequences.

Design/methodology/approach
First, the restored sequence of the GM(1, 1) model is proved to be convex, and the residual characters of the GM(1, 1) model for concave sequences are analyzed. Second, two symmetry transformations are introduced to transform an original concave sequence into a convex sequence, and then the GM(1, 1) model is established based on the convex sequence.

Findings
Compared with the traditional modeling method, the new method has high accuracy and is applicable for all concave sequence modeling.

Practical implications
Two cases are used to illustrate the superiority of this modeling method. Case A is to predict China’s per capita natural gas consumption, and case B is to predict the annual output of an oilfield.

Originality/value
The application scope of GM (1, 1) model is greatly extended.
The academic and personal experiences of Mainland Chinese students enrolled in a Canadian Master of Education Program
Authors: Preston Jane P. , Wang Anhui 
Published: October 2017

PurposeThe purpose of this paper is to communicate the positive and challenging aspects of a Master of Education program, as perceived by Chinese students at an Atlantic Canadian university.Design/methodology/approachAssuming a qualitative methodology, 21 Mainland Chinese students participated in individual, paired, and focus group semi-structured interviews. Interviews were member checked. Data were analyzed through content analysis. The findings are discussed using Deardorff’s (2006, 2009) concept of intercultural competence.FindingsStudents perceived the best features of their educational experience to be personable instructors, their enhanced English skills, and practical course-based experiences embedded in the program. The main challenges were social isolation, English language requirements and related assignments, and theoretical expectations of the program.Research limitations/implicationsThis study contains a somewhat small qualitative small sample size (i.e. 21 participants), therein, disabling any generalization of results. In other words, the data findings are unique and non-generalizable beyond the particular research case. However, transferability, which refers to the extent in which the results of an original study can be applied to similar people, contexts, or settings (Lincoln and Guba, 1985), may be applied to the findings if the reader deems the context of this study in alignment with his/her situation.Practical implicationsApproximately, 82 percent of Canadian universities rate internationalization as a top priority, supporting the need for research in this area. An implication of the study is that internationalization of higher education must be more than just the recruitment of international students. Universities have direct and fiduciaries responsibilities to support the academic needs, personal needs of their international students, as well as the intercultural competence of all students, instructors and staff.Originality/valueThere is a plethora of research documenting experiences of international students, in general, but such research is not directly transferrable to the Chinese student. The issues and problems encountered by Chinese international students are unique and should be addressed independently from international students. Moreover, a lot of the research that focuses on Chinese students enrolled in North American universities, predominantly, is conducted within the USA, and such research tends to spotlight the challenges only. In turn, the authors’ research addresses a specialized focus of the international Chinese student in Canada.
Friction and wear behavior of pin-bushing with magnetorheological fluids
Authors: Zhang Peng , Lee Gwanghee , Lee Chulhee , Yoon Hyung 
Published: October 2017

Purpose
The purpose of this paper is to carry out research on friction and wear behavior of pin-bushing with magnetorheological fluids (MRFs).

Design/methodology/approach
The oscillation friction characteristics of MRFs with a magnetic field are evaluated by a pin-bushing friction wear tester. The housing is adjusted to apply the magnetic field to MRFs. Experiments are carried out with and without a magnetic field, and the coefficient of friction and temperature on the contact interface are measured. The surfaces of the pin and bushing are also examined by a surface profilometer and an optical microscope before and after tests. The experiment results show a lower coefficient of friction is observed when a magnetic field is applied.

Findings
The temperature is lowest when grease is used. The case when a magnetic field is present shows the higher temperature. The coefficient of friction is higher than grease lubrication when an MRF is applied. The coefficient of friction of the pin-bushing is lowest with grease and highest when a magnetic field is present. The friction coefficient of grease and MRFs decreases as the load increases and remains stable after 3 kN is added. The roughness, surface profile and morphology of the pin show the best results when grease is used as compared with MRFs.

Originality/value
The tribology characteristic of pin-bushing with MRFs shows more deficiency than that with grease. Nevertheless, it is necessary to carry out the research on the friction and wear characteristics of a pin-bushing with MRFs, as it is expected to increase the load-carrying capacity when an MRF is applied to the pin-bush system. Better friction and wear characteristics could be achieved by enhancing the property of MRFs.
Experimental study of wear for implant materials under dry sliding conditions
Authors: Mojumder Soumyajit , Sikdar Soumya , Ghosh Subrata Kumar 
Published: October 2017

Purpose
Artificial biomaterials are implanted to the human body to support the structure depending upon the extent of deformity or damage. This paper aims to formulate an experimental approach to assess the suitability of materials that can be used in the manufacture of human implants.

Design/methodology/approach
Five different pin materials such as SS304, Alumina, HDPE, UHMWPE and Brass have been chosen to be suitable for implants. The tribological properties of the aforementioned materials have been tested on a simple pin-on-disc apparatus. EN31 was chosen as the disc material because its hardness value is much higher than that of the pin materials used. The test materials were constructed in the form of spherical end pins to have point contacts and to reduce the depth of wear.

Findings
It has been observed that the polymeric (HDPE and UHMWPE) and ceramic materials (Alumina) are much better than the traditional metallic materials. The wear rate is very low for these materials owing to their self-lubricating properties.

Practical implications
The experimental studies will help predict the performance and life of implant materials in the human body.

Originality/value
In most cases, SS316L that possesses nickel compositions is used as the disc material; SS316L is toxic to the human body. In the present study, a high carbon alloy steel with high degrees of hardness EN31 is used as a disc counter-face material.
Synthesis and properties of thiadiazole lubricant additives
Authors: Xue Weiguo , Ma Wenquan , Xu Xiaohong , Li Tao , Zhou Xuguang , Wang Peng 
Published: October 2017

Purpose
Thiadiazole compounds and their derivatives have carrying capacity and good lubricating properties. However, their poor oil-solubility limited their wide usage in lubricating oil. The study aims to develop thiadiazole lubricant additives with better oil-solubility. When the hindered phenol antioxidation functional group and alkyl-chain are introduced to thiadiazole, the resulting product could have better oil-solubility and excellent antioxidation resistance, anti-wear and corrosion resistance in the lubricating oil.

Design/methodology/approach
One kind of thiadiazole lubricant additive, for the first time, has been synthesized from 2,5-dimercapto-1,3,4-thiadiazole. Its tribological performance has also been evaluated by four-ball test. And, its oxidation resistance has been estimated by rotating pressure vessel oxidation test and pressurized differential scanning calorimetry. The anticorrosion performance of such an additive has been studied by GB/T 5096 standard method test.

Findings
The synthesized thiadiazole additive has excellent anti-oxidation capability, good anti-wear and extreme pressure properties and good anticorrosion performance, in comparison with zinc dialkyl dithiophosphate (ZDDP). In base oils, the comprehensive performance of thiadiazole additive is comparable to ZDDP. Mechanistic studies indicate that the S and N active elements were involved in the formation of a boundary film. This may account for the formation of a composite membrane on the metal surface and thus for the tribological performance of such thiadiazole additives.

Originality/value
The thiadiazole derivatives, which are ashless and have environmentally friendly features, are a potential alternative to ZDDP. Because of the film formed on the friction surface, thiadiazole compounds may serve as an excellent anti-wear additive and are expected to reduce friction and wear between metals.
Life of cutlery cutting tools: effects of surface finish
Authors: Labiapari Wilian da Silva , Costa Henara Lillian , De Mello José Daniel Biasoli 
Published: October 2017

Purpose
The progressive wear of cutting tools used in industrial cutlery production results in excessive burr formation and reduces tool service life. This paper aims to investigate the effects of the sheet surface finish on tool wear and service life during blanking.

Design/methodology/approach
Two alternative surface finish techniques were proposed and initially implemented under laboratorial conditions and compared with conventional acid pickling. Those surface finish techniques were then implemented on an industrial scale to improve the service life of cutting tools. Industrial blanking tests characterized the effect of sheet surface finish on tool life.

Findings
In the first technique, called skin pass, an additional mechanical pass under controlled conditions reduced the height of the surface peaks and resulted in partial embedding of the carbides into the surface. The second technique, called electrochemical pickling, removed solely the surface carbides, leaving behind a smoother surface without carbides. Real industrial blanking tests identified that the use of skin pass reduced burr formation and increased tool life by around 300 per cent when compared with conventional acid pickling. With electrochemical pickling, burr formation was further reduced and tool life increased further by 300 per cent when compared with skin pass.

Research limitations/implications
First, this work proposes an alternative surface finishing technique (electrochemical pickling) to be used after annealing of stainless steel. Second, the work clearly shows the presence of protruding surface carbides when conventional surface finishing techniques are used, which do not exist after acid pickling.

Practical implications
When electrochemical pickling is implemented on an industrial scale, the life of blanking tools is substantially improved.

Originality/value
Although the sheet surface finish is widely recognized to affect metalforming processes, the literature lacks studies on the effect of sheet surface finish on tool wear during blanking. First, this work proposes an alternative surface finishing technique (electrochemical pickling) to be used after annealing of stainless steel. Second, the work clearly shows the presence of protruding surface carbides when conventional surface finishing techniques are used, which do not exist after acid pickling. Third, when electrochemical pickling is implemented on an industrial scale, the life of blanking tools is substantially improved.