bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fluid displacement from intraluminal thrombus of abdominal aortic aneurysm as a result of uniform compression
Authors: van Noort Kim , Schuurmann Richte CL , Wermelink Bryan , Slump Cornelis H , Kuijpers Karel C , de Vries Jean-Paul PM 
Published: April 2017

Objectives The results after aneurysm repair with an endovascular aneurysm sealing (EVAS) system are dependent on the stability of the aneurysm sac and particularly the intraluminal abdominal aortic thrombus (ILT). The postprocedural ILT volume is decreased compared with preprocedural ILT volume in aortic aneurysm patients treated with EVAS. We hypothesize that ILT is not stable in all patients and pressurization of the ILT may result in displacement of fluids from the ILT, no differently than serum is displaced from whole blood when it settles. To date, the mechanism and quantification of fluid displacement from ILT are unknown. Methods The study included 21 patients who underwent elective open abdominal aortic aneurysm repair. The ILT was harvested as a routine procedure during the operation. After excision of a histologic sample of the ILT specimen in four patients, ILT volume was measured and the ILT was compressed in a dedicated compression setup designed to apply uniform compression of 200 mmHg for 5 min. After compression, the volumes of the remaining thrombus and the displaced fluid were measured. Results The median (interquartile-range) of ILT volume before compression was 60 (66) mL, and a median of 5.7 (8.4) mL of fluid was displaced from the ILT after compression, resulting in a median thrombus volume decrease of 11% (10%). Fluid components can be up to 31% of the entire ILT volume. Histologic examination of four ILT specimens showed a reduction of the medial layer of the ILT after compression, which was the result of compression of fluid-containing canaliculi. Conclusions Applying pressure of 200 mmHg to abdominal aortic aneurysm ILT resulted in the displacement of fluid, with a large variation among patients. Fluid displacement may result in decrease of ILT volume during and after EVAS, which might have implications on pre-EVAS volume planning and on stability of the endobags during follow-up which may lead to migration, endoleak or both.
KLF1 directly activates expression of the novel fetal globin repressor ZBTB7A/LRF in erythroid cells
Authors: Norton Laura J. , Funnell Alister P. W. , Burdach Jon , Wienert Beeke , Kurita Ryo , Nakamura Yukio , Philipsen Sjaak , Pearson Richard C. M. , Quinlan Kate G. R. , Crossley Merlin 
Published: April 2017

Key PointsKLF1 directly drives expression of ZBTB7A, a key repressor of fetal γ-globin gene expression, in erythroid cells. An erythroid-specific regulation mechanism allows upregulation of a novel ZBTB7A transcript in erythroid cells.
Can a search model predict the effects of an increase in the benefit duration? Evidence from the Portuguese unemployment insurance reform
Authors: Novo Álvaro A. , Silva André C. 
Published: April 2017

Abstract
We test the predictions of an equilibrium search model about the effects of an increase in the maximum duration of unemployment benefits. We use the 1999 unemployment insurance reform of Portugal, a quasi-natural experiment. The reform increased the maximum duration of benefits for three groups of agents and maintained all features of the unemployment insurance for two other groups. We isolate the effects of the increase in the maximum duration of benefits and test the model. The model successfully predicts the effects on the unemployment rate, the labor force participation, and the levels of unemployment and employment.
Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients With Cancer
Authors: Katakami Nobuyuki , Oda Koji , Tauchi Katsunori , Nakata Ken , Shinozaki Katsunori , Yokota Takaaki , Suzuki Yura , Narabayashi Masaru , Boku Narikazu 
Published: April 2017

Purpose This randomized, double-blind, multicenter study aimed to determine the dose of naldemedine, a peripherally-acting μ-opioid receptor antagonist, for future trials by comparing the efficacy and safety of three doses of naldemedine versus placebo in patients with cancer and opioid-induced constipation. Methods Patients ≥ 18 years old with cancer, an Eastern Cooperative Oncology Group performance status ≤ 2, who had been receiving a stable regimen of opioid analgesics for ≥ 2 weeks, had at least one constipation symptom despite laxative use, and no more than five spontaneous bowel movements (SBMs) during the past 14 days, were randomly assigned (1:1:1:1) to oral, once-daily naldemedine 0.1, 0.2, or 0.4 mg, or placebo, for 14 days. The primary end point was change in SBM frequency per week from baseline during the treatment period. Secondary end points included SBM responder rates, change from baseline in the frequency of SBM without straining, and complete SBM. Safety was also assessed. Results Of 227 patients who were randomly assigned, 225 were assessed for efficacy (naldemedine 0.1 mg, n = 55; 0.2 mg, n = 58; 0.4 mg, n = 56; placebo, n = 56) and 226 for safety. Change in SBM frequency (primary end point) was higher with all naldemedine doses versus placebo ( P < .05 for all comparisons), as were SBM responder rates and change in complete SBM frequency. Change in SBM frequency without straining was significantly improved with naldemedine 0.2 and 0.4 (but not 0.1) mg versus placebo (at least P < .05). Treatment-emergent adverse events were more common with naldemedine (0.1 mg: 66.1%; 0.2 mg: 67.2%; 0.4 mg: 78.6%) than placebo (51.8%); the most common treatment-emergent adverse event was diarrhea. Conclusion Fourteen-day treatment with naldemedine significantly improved opioid-induced constipation in patients with cancer and was generally well tolerated. Naldemedine 0.2 mg was selected for phase III studies.
Mineral waters, spas and therapeutics in seventeenth and eighteenth century Portugal
Authors: Dias José Pedro Sousa 
Published: April 2017

Abstract
This article presents a general outline of the growing interest in medicinal waters and spas in Portugal during the eighteenth century, with special emphasis on the theoretical attitude and practice of the medical community and the ruling classes regarding mineral waters and on the development of the main institutions dedicated to hydrotherapy, trying to interpret the obstacles that prevented a more general social acceptance of spas and a greater adherence of physicians to therapeutic use of mineral waters in Portugal in this period.
Assessment of quantitative relationship between blood and PRF for periodontal surgeries
Authors: Indurkar Maya S , Bhailume Pallavi Sunil 
Published: April 2017

Aim: The aim of study is to measure the amount of PRF obtained from different quantity of blood withdrawn from patients & the amount of PRF and its use in different periodontal surgical procedures.Materials and method: 15 subjects undergoing regenerative periodontal surgical therapy in whom use of PRF was indicated were included in the study. 15 subjects were divided into 3 three groups. In group A: 5ml of blood was withdrawn from 5 subjects. In group B: 10ml of blood was withdrawn from 5 subjects. In group C: 12ml of blood was withdrawn from 5 subjects. The steps involved were as follows:1)Â Â Â Â Â Blood specimen was withdrawn from the patient,2)Â Â Â Â Â The blood specimen was immediately placed in the centrifuge and was allowed to spin for 10mintes at 3000RPM,Weight of obtained PRF was measured by using weighing scale and also length, depth & width was measured by using UNC 15 probe.Result and Conclusion: The amount of PRF obtained depends upon the quantity of blood withdrawn. Thus, result of the present study is helpful to the operator to decide the quantity of blood to be withdrawn for particular patient to obtain desired amount of PRF.
Pentraxin 3 and atherosclerosis among type 2 diabetic patients
Authors: Nabrdalik Katarzyna , Chodkowski Artur , Bartman Wojciech , Tomasik Andrzej , Kwiendacz Hanna , Sawczyn Tomasz , Kukla Michał , Grzeszczak Władysław , Gumprecht Janusz 
Published: April 2017

AbstractType 2 diabetes is contemporarily a major social and epidemiological problem and among others is a strong risk factor for cardiovascular diseases. Pentraxin 3, a potential early biomarker of atherosclerosis, is an acute-phase reactant produced by the peripheral tissues where the inflammation takes place. In this study we examined a group of patients with type 2 diabetes with and without cardiovascular complications compared to persons with normal glucose tolerance (patients with cardiovascular complications and healthy volunteers). Plasma pentraxin 3 concentration as well as some basic biochemical blood analysis were performed. Moreover, transcranial and carotid Doppler ultrasound examination as well as transthoracic echocardiography were performed. It turned out that there was an association of plasma pentraxin 3 concentration and carotid atherosclerosis found in the control group of patients with cardiovascular complications but with normal glucose tolerance. In the group of patients with type 2 diabetes and cardiovascular complications we have found an association of plasma pentraxin 3 concentration with diastolic left ventricular dysfunction. Additionally, in the group of patients with type 2 diabetes without cardiovascular disease plasma pentraxin 3 concentration was associated with elevated urinary albumin creatinine ratio. Further studies, on a larger group of patients, are required to confirm these observations.
Do you know what you eat? Students of the Medical University of Lublin and food consumption awareness
Authors: Chylinska-Wrzos Patrycja , Lis-Sochocka Marta , Wawryk-Gawda Ewelina , Bulak Kamila , Jodlowska-Jedrych Barbara 
Published: April 2017

Abstract
At the present time, consumers are paying more attention to the food items they purchase, and, hence, organic products, more and more, are a popular choice. Furthermore, there is an increased awareness of the ingredients added as fixatives and taste modifiers. Medical students are assumed to have greater health awareness, and to recognize that proper nutrition has a significant impact on the overall physical well-being. Moreover, they are thought to be aware of the chemical composition of consumed foods. The aim of our study was to truly assess the degree of consumer awareness amongst students of the Medical University of Lublin.
The research study consisted of 301 students of the I and II years, the work being performed at the turn of the year 2014/2015. The research tool was an anonymous questionnaire. This contained questions regarding their degree of healthy food awareness of retailed food products.
The results of this study revealed that about 44% of the respondents always or often pay attention to the composition of the food products which they buy. Indeed, the highest percentage of all respondents declared that their purchase of food products is guided by the declared (labeled) composition (48.84% of the students coming from urban settings, and 55.81% coming from rural districts). Of note, regarding products labeled organic, from both urban and rural origin, such items were chosen by approximately 50% of the respondents. Finally, only a small percentage of students (about 9% overall) stated that they avoid foods stated to contain preservatives.
In summary, despite the increasing availability of healthy foods, such items are not too often chosen by UM students - Indeed, despite the large biomedical knowledge purportedly held, medical students, in particular, do not avoid foods containing preservatives.
The international normalized ratio (INR) as seen in a population of patients with atrial fibrillation and cerebral infarction undergoing long-term treatment with vitamin K antagonists
Authors: Szczepańska-Szerej Anna , Wojtan Magdalena , Szajnoga Beata 
Published: April 2017

Abstract
It is estimated that nearly 20% of all cerebral infarctions in the total population are the result of a complication of atrial fibrillation (AF). While oral anticoagulation with vitamin K antagonists (AVKs) substantially reduces this risk, this requires regular monitoring of the international normalized ratio (INR) in order to achieve therapeutic levels (2,0-3,0). The aim of this study was to evaluate a group at high risk of cerebral infarction, among patients with AF undergoing long-term treatment with VKAs, taking into account the significance of therapeutic INR values. The analysed group consisted of 90 acute ischaemic stroke patients with paroxysmal or chronic “non-valvular” AF, receiving treatment with VKAs. As a result of the study, therapeutic INR values (≥ 2) were seen in thirty-five of these individuals (38,8%), while 55 (61,2%) showed non-therapeutic INR values. Moreover, there were no differences in demographics, vascular risk factors, biochemical and morphological blood parameters, mean CHA2DS2-VASc score and TOAST classification between either of the two groups. Furthermore, no additional factor that would increase their risk of cerebral infarction during the adequate treatment with VKAs was found. However, patients with non-therapeutic INR values had a statistically significantly higher frequency of concomitant moderate pathology of the bicuspid valve, p<0.05. Hence, a lack of proper control of INR can proved to be particularly dangerous for this subgroup of patients. Hence, this is a group with an elevated risk of cerebral infarction and therefore requires special oversight of VKA treatment or NOA treatment.
Brightness stability of eucalyptus-dissolving pulps: effect of the bleaching sequence
Authors: Perrin Jordan , Lachenal Dominique , Chirat Christine 
Published: April 2017

AbstractThe factors governing the brightness reversion (BR) of dissolving pulps under heat exposure are investigated. Carbonyl (CO) groups were artificially introduced on fully bleached pulp by sodium hypochlorite (NaClO) oxidation. It was demonstrated that the CO groups are responsible for loss of brightness stability (BS). These groups were partly eliminated by an alkaline extraction stage (E), which improved BS. However, an alkaline peroxide stage (P) was more efficient than E to improve BS, but without any additional CO loss. Moreover, an unbleached dissolving pulp was bleached in the laboratory by elemental chlorine free (ECF) and totally chlorine free (TCF) [ozone-based] sequences to the same brightness. The very low CO content was about the same in both cases. The ECF-bleached pulp showed substantially lower BS than the TCF pulp. These results are interpreted such that the chemistry of chromophores in the unbleached pulp also governs BS.In situdetection of phenolic and quinone chromophores in bleached dissolving pulp was performed by electron paramagnetic resonance (EPR) spectroscopy and ultraviolet resonance Raman (UVRR) spectroscopy. The content of these groups was bleaching-sequence-dependent, which may be related to the BS differences.
Testing for Nonlinearity in Conditional Covariances
Authors: Sanhaji Bilel 
Published: April 2017

AbstractWe propose two Lagrange multiplier tests for nonlinearity in conditional covariances in multivariate GARCH models. The null hypothesis is the scalar BEKK model in which covolatilities of time series are driven by a linear function of their own lags and lagged squared innovations. The alternative hypothesis is an extension of the model in which covolatilities are modeled by a nonlinear function of the lagged squared innovations, represented by an exponential or a logistic transition function. Moreover, on the same basis we develop two other tests that are robust to leverage effects. We investigate the size and power of these tests through Monte Carlo experiments, and we provide empirical illustrations in many of which cases these tests encourage the use of nonlinearity in conditional covariances.
Hopf bifurcations in a three-species food chain system with multiple delays
Authors: Xie Xiaoliang , Zhang Wen 
Published: April 2017

Abstract
This paper is concerned with a three-species Lotka-Volterra food chain system with multiple delays. By linearizing the system at the positive equilibrium and analyzing the associated characteristic equation, the stability of the positive equilibrium and existence of Hopf bifurcations are investigated. Furthermore, the direction of bifurcations and the stability of bifurcating periodic solutions are determined by the normal form theory and the center manifold theorem for functional differential equations. Finally, some numerical simulations are carried out for illustrating the theoretical results.
Growth functions for some uniformly amenable groups
Authors: Dronka Janusz , Wajnryb Bronislaw , Witowicz Paweł , Orzechowski Kamil 
Published: April 2017

Abstract
We present a simple constructive proof of the fact that every abelian discrete group is uniformly amenable. We improve the growth function obtained earlier and find the optimal growth function in a particular case. We also compute a growth function for some non-abelian uniformly amenable group.
Structural and morphological analysis of barium cerate electrolyte for SOFC application
Authors: Senthil Kumar A. , Balaji R. , Puviarasu P. , Jayakumar S. 
Published: April 2017

AbstractGadolinium doped barium cerate (BCG) electrolytes Ce0.8Gd0.2O1.9+ xBaO (x = 0.1 and 0.4) were prepared by wet chemical method for the use in solid oxide fuel cells operating at intermediate temperatures (600 °C to 800 °C). The as-prepared powder sample was calcined at 900 °C. The calcination temperature was identified using differential scanning calorimetry (DSC) analysis. The orthorhombic perovskite phase formation was confirmed by XRD analysis. From TEM results, the particle size was found to be about 32 nm which is in a good agreement with XRD results. BCG nanoparticles were formed at lower sintering temperature due to using microwave furnace. By reducing the sintering temperature of solid electrolyte through microwave technique, the percentage of barium loss was successfully reduced and the prepared electrolyte can be a good choice for solid oxide fuel cells operating at intermediate temperatures.
Synthesis and characterization of γ-glycine – a nonlinear optical single crystal for optoelectronic and photonic applications
Authors: Latha A. Arputha , Anbuchezhiyan M. , Kanakam C. Charles , Selvarani K. 
Published: April 2017

Abstract
A single crystal of gamma-glycine (GG), a polymorph of glycine, was synthesized by crystallization. The single crystal of GG was grown from an aqueous solution. The morphology of GG was studied in order to assess its growth facets. The good quality single crystals were subjected to X-ray diffraction studies to reveal their structure. The FT-IR spectral analysis was carried out to confirm the presence of expected functional groups. The UV-Vis analysis was done for GG single crystals to determine the optical transparency and band gap. Simultaneous TG-DTA analysis was employed to understand the thermal and physicochemical stability of the title compound. The mechanical stability and laser stability of GG single crystal were studied using Vickers microhardness test and laser induced damage threshold on different planes of the crystal to reveal its anisotropic nature. The dielectric measurement was carried out as a function of frequency and the results were discussed. The existence of second harmonic generation (SHG) of the title compound was confirmed by Kurtz-Perry powder technique. The SHG effective nonlinearity and particle size dependence of GG powder sample were compared with a standard reference material: potassium dihydrogen phosphate (KDP).
Random walk-based similarity measure method for patterns in complex object
Authors: Liu Shihu , Chen Xiaozhou 
Published: April 2017

Abstract
This paper discusses the similarity of the patterns in complex objects. The complex object is composed both of the attribute information of patterns and the relational information between patterns. Bearing in mind the specificity of complex object, a random walk-based similarity measurement method for patterns is constructed. In this method, the reachability of any two patterns with respect to the relational information is fully studied, and in the case of similarity of patterns with respect to the relational information can be calculated. On this bases, an integrated similarity measurement method is proposed, and algorithms 1 and 2 show the performed calculation procedure. One can find that this method makes full use of the attribute information and relational information. Finally, a synthetic example shows that our proposed similarity measurement method is validated.
A Mathematical Study of Accessibility and Cohesion Degree in a High-Speed Rail Station Connected to an Urban Bus Transport Network
Authors: Mota Carmen , López Miguel A. , Martínez-Rodrigo Arturo 
Published: April 2017

Abstract
In the last twenty years, the implementation of High-Speed Rail (HSR) has been one of the major strategies for territorial structuring used by various countries. This model has enhanced the development of countries such as France, Spain, Germany and Japan. At present, the United States and China are also starting to implement this model. Nevertheless, the lack of social and economic profitability of several networks is being increasingly analysed. Many networks located in particular regions serve populations that are not large enough to recover the initial investment. For this reason, it is necessary to evaluate the population served by this transport mode, beyond the number of users. In this sense, it is essential to identify the deficiencies and potentials of implementing a network linked to other secondary networks in a specific territory which can compensate for the so-called tunnel effect. This article proposes to apply a mathematical approach based on graph theory to measure the Degree Accessibility Node (DAN) in a constrained Geographic Information System (GIS) model. Hence, it would be possible to compare regions, especially medium-sized cities, where the implementation of HSR could represent a qualitative leap due to incorporation into large transport networks. The DAN function uses static and dynamic studies to evaluate the level of connection of stations to secondary transport networks—local public transport in this case. Thus, the impact of high-speed trains could be spread to greater territorial and population ranges. Four cases have been studied, two in Germany (one of them, Fulda, is analysed in depth throughout this article) and two in Spain. These two countries were selected since HSR was implemented in the same relative period of time, in comparison with other European countries. Results show relevant differences, suggesting a review of inappropriate policies of transport integration in a city that could weaken the expansion of the positive effects of HSR integration.
Design and Simulation of the Integrated Navigation System based on Extended Kalman Filter
Authors: Zhou Weidong , Hou Jiaxin , Liu Lu , Sun Tian , Liu Jing 
Published: April 2017

AbstractThe integrated navigation system is used to estimate the position, velocity, and attitude of a vehicle with the output of inertial sensors. This paper concentrates on the problem of the INS/GPS integrated navigation system design and simulation. The structure of the INS/GPS integrated navigation system is made up of four parts: 1) GPS receiver, 2) Inertial Navigation System, 3) Extended Kalman filter, and 4) Integrated navigation scheme. Afterwards, we illustrate how to simulate the integrated navigation system with the extended Kalman filter by measuring position, velocity and attitude. Particularly, the extended Kalman filter can estimate states of the nonlinear system in the noisy environment. In extended Kalman filter, the estimation of the state vector and the error covariance matrix are computed by steps: 1) time update and 2) measurement update. Finally, the simulation process is implemented by Matlab, and simulation results prove that the error rate of statement measuring is lower when applying the extended Kalman filter in the INS/GPS integrated navigation system.