bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efek Kompres Hangat dan Pemberian Air Kelapa terhadap Dismenore Primer pada Remaja Putri Pondok Pesantren Modern Al Ikhlash Putri Kuningan
Authors: Rukoyah Oya Siti , Triwahyuningsih Ria Yulianti , Kumalasary Diyanah , Nurfita Nisa Rizki 
Published: September 2024

Latar Belakang: Kalangan remaja putri yang tengah menstruasi menunjukkan masih tingginya angka kejadian dismenore primer yang sangat mengganggu berupa kram perut atau gangguan nyeri yang diikuti dengan penyebaran rasa sakit menuju punggung, sakit kepala, mual dan muntah, sampai diare, sehingga harus beristirahat serta dalam kurun waktu tertentu meninggalkan aktivitas serta pekerjaannya.
Tujuan: Penelitian ini dimaksudkan untuk mengidentifikasi pengaruh kompres hangat dan pemberian air kelapa terhadap dismenore primer pada remaja putri Pondok Pesantren Modern Al-Ikhlash Putri Kabupaten Kuningan.
Metode: Penelitian ini adalah penelitian pra eksperimental dengan desain penelitian one group pre-test post-test design. Sejumlah 83 remaja putri kelas 1-3 SMA berusia 14-18 tahun dipilih sebagai populasi. Instrumen yang digunakan adalah Standard Operating Procedure (SOP) dan lembar ceklis (observasi dan wawancara). Pengolahan data dilakukan dengan menggunakan program SPSS. Teknik purposive dipilih dalam mengambil sampel, sehingga diperoleh 26 remaja yang relevan dengan kriteria inklusi maupun eksklusi. Data yang dihimpun adalah data primer. Analisis univariat serta bivariat digunakan dengan paired t-test dalam menguji pengaruh serta chi-square test dalam menguji korelasi tiap variabel.
Hasil: Terdapat uji beda dengan hasil p-value 0,000, ditemukan pengaruh signifikan antara nyeri haid sebelum maupun sesudah kompres hangat dan pemberian air kelapa pada remaja putri.
Kesimpulan: Pemberian kompres hangat dan mengonsumsi air kelapa secara rutin dapat meminimalisir nyeri haid remaja putri.
Tiered Training Model to Improve the Skills of Posyandu Cadres in Measuring Child Anthropometry in Demak Regency, Indonesia
Authors: Suyatno Suyatno , Kartasurya Martha Irene , Susanto Henry Setyawan 
Published: September 2024

Background: Posyandu cadres still lack the skills to measure anthropometry. Not all cadres received regular training.
Objectives: This study aims to develop a training model to improve the skills of Posyandu cadres in conducting anthropometric measurements.
Methods: This study used a research and development approach with two main stages. The first stage was the development of the training model. The second stage was field testing of the new training model, using a pretest-posttest control group design. The training model in the form of Training of trainers (ToT) was tested to 49 cadres in the treatment and control groups with expert resource persons, followed by grassroots training with 142 cadres in the treatment group and 146 cadres in the control group with resource persons from the ToT participants. The intervention lasted three months. The effect of applying the training model on changes in the ability of cadres in anthropometric measurements was analyzed using the General Linear Model with a significant p-value <0.05.
Results: The developed anthropometry training model is tiered training, including ToT followed by grassroots training. Through the implementation of this training model, the number of trained cadre participants increased threefold. The results of the tiered anthropometry training model trial proved to improve knowledge, attitude, practice, self-efficacy, as well as the precision and accuracy of measuring the length, height, and weight of children by Posyandu cadres (p<0.05).
Conclusions: The implementation of a tiered anthropometry training model can increase cadre participants and improve the capacity of cadres in measuring child anthropometry.
Strategi Implementasi Program Smart Indonesia
Authors: Rachmahnia Lia , Choiriyah Ilmi Usrotin 
Published: September 2024

This study investigates the implementation of the Smart Indonesia Program (PIP) at Buduran 1 State Vocational School in Sidoarjo Regency using a qualitative descriptive research method. Through interviews, observation, and documentation, data was collected from key informants, including the school principal, administrative staff, and program beneficiaries. The study reveals that PIP is effectively communicated through special events and verbal interactions with students. The school has provided sufficient facilities, such as computers and wifi, and benefits from supportive factors like parental involvement and collaboration between Guidance and Counseling teachers. However, challenges arise from communication gaps between funding agencies and schools, impacting data accuracy. The findings underscore the need for streamlined communication channels to optimize PIP implementation.
Highlight :

Effective Communication: The study emphasizes the importance of special events and verbal communication in disseminating information about the Smart Indonesia Program, ensuring awareness among students and stakeholders.
Facility Provision: Buduran 1 State Vocational School's proactive approach in providing adequate facilities, including computers and wifi, contributes to the successful implementation of the Smart Indonesia Program.
Communication Challenges: The research highlights the inhibiting factor of communication gaps between channeling agencies and schools, impacting fund collection and data accuracy, underscoring the need for improved communication channels.

Keywords: Smart Indonesia Program, Vocational Education, Implementation Analysis, Communication, Facilities
Implementation of the Integrated Waste Management Site (TPST) Program
Authors: Ali Mochammad Fachrizal , Umar Ahmad Riyadh 
Published: September 2024

The study analyzed the implementation of waste management at BUMDes Bhirawa in the Mekarsari Integrated Waste Treatment Site (TPST) in Kureksari Village using a qualitative descriptive method. Data was gathered from interviews, observation, documentation, and literature studies, and the informants included the Bhirawa BUMDes Secretary, the Kureksari Village Government, and the TPST users. The research revealed four variables: communication, data source, dispositions, and bureaucratic structure. The results emphasized the importance of effective communication, data management, employee attitudes, and bureaucratic structure for successful waste management programs Highlight : Communication: The study emphasizes the importance of effective communication in waste management programs. Communication was carried out through electronic media, socialization, and training. Data Management: The study highlights the significance of data management in waste management programs. The data source was sufficient, with a special budget for employee salaries and TPST maintenance. Employee Attitudes and Bureaucratic Structure: The study suggests that employee attitudes and bureaucratic structure play a crucial role in successful waste management programs. The results revealed that employees were responsible for their duties, and the bureaucratic structure had clear standard operating procedures and a well-executed division of responsibilities. Keywords: Waste Management, BUMDes Bhirawa, Mekarsari Integrated Waste Treatment Site (TPST), Kureksari Village, Qualitative Descriptive Method
Consumptive hypothyroidism complicating infantile hepatic hemangioma successfully treated with propranolol: a case report and literature review
Authors: Bettini Irene , Poletti Giulia , Rocca Alessandro , Natale Valeria di , Gennari Monia , Lanari Marcello , Pession Andrea , Cassio Alessandra 
Published: September 2024

Abstract

Background
consumptive hypothyroidism (CH) is a rare paraneoplastic syndrome, caused by the overexpression in vascular tumors of type 3 deiodinase (D3), converting thyroid hormones into inactive metabolites.
Case presentation
We report the case of a 2-months-old male infant with diffuse infantile hepatic hemangioma (IHH). Thyroid function screening detected a CH. The patient was promptly treated with propranolol: after 2 weeks, a marked reduction in tumour size was observed and thyroid function was restored. No hormone replacement therapy was required. We then performed a literature review on PubMed/Medline: based on the title and abstract, we extracted 64 cases of CH secondary to IHH published between 2000 and 2023. 59.37% patients received propranolol, either alone (52.63%) or in combination with other treatments. 18.75% patients required surgical treatment or liver transplant. LT4 was administered in 92.85% of the patients. Patients who received propranolol required a lower dosage of LT4 than patients who received other treatments.
Conclusions
thyroid function should be evaluated in all children with IHH to rule out CH. Early recognition of IHH and CH and prompt therapy with propranolol can effectively treat IHH and the subsequent hypothyroidism, sometimes even without the need of hormone replacement therapy.
Linear Body Measurements as indicators for Body Weight in Three Genotypes of Chickens in Zimbabwe
Authors: Assan Never 
Published: September 2024

Abstract

A study of 397 mature hens (155 Astrolope; 154 Boschveld; 88 Sasso) was conducted to assess body weight and linear body measures, including neck length (NL), Body Circumference (BC), Body Length (BL), Shank Length (SL), and Shank Circumference.The results showed significant differences in BWT, BC, BL, SC, and SL for all chicken breeds, with p-values less than 0.05. However, there was a slight difference in neck length and shank circumference, with p values less than alpha value 0.05. Astrolope had the highest weight and largest size, followed by Boshveld and Sasso. The study found that Boshveld chickens had the strongest association coefficient with body weight, with a 0.50 correlation between shank circumference and neck length. Sasson chickens showed a positive association with body weight and body dimensions, but the overall relationship was weaker. Astrolope chickens can predict body weight by direct selection of the neck length. Astrolope chickens had the highest body circumference, body length, shank circumference, and neck length. Linear body measurements as sole predictors of body weight were ineffective, with values ranging from 0.02–0.34, 0.03–0.15, and 0.05–0.27 for SC, AC, and BC, respectively. However, fitting multiple regressions improves this prediction. Boshveld et al. provided the best multiple linear regression model that connected body weight and linear body measures. The study concluded that linear body measurements may not be effective predictors of body weight in the Astrolope, Boschveld, and Sasso chicken populations of Zimbabwe, and that other predictive models that fit quadratic or cubic growth may need to be explored. In addition, chicken breeds vary in size and body weight, with Astrolope being larger and heavier.
FOLR1 enhances the radioresistance of gastric cancer via the rescue of damaged DNA
Authors: Liu Lei , yang Tian , Yu Siting , Xiang Zhongzheng , Zeng Yuanyuan , Wang Jun , Bai Liping , Dai Zelei , Xu Ningyue , Wu Qinjie , Gong Changyang 
Published: September 2024

Abstract

Gastric cancer (GC) is a multifactorial malignancy with high incidence and mortality rates worldwide. Radiotherapy plays a crucial role in the comprehensive treatment of GC patients; however, its clinical benefits are still limited due to radioresistance. FOLR1 is known to predict poor prognosis in tumor patients and is involved in various biological processes, such as cell proliferation and apoptosis. However, its role in GC radioresistance has not been previously described. In this study, we investigated the role of FOLR1 in GC radioresistance through cell proliferation, apoptosis, migration and invasion assays using three GC cell lines (MKN-45, AGS, and MGC-803) and radiation-induced radioresistant GC cell line SGC-R. The results showed that FOLR1 was highly expressed in the radioresistant cell line SGC-R. Furthermore, we found that FOLR1/TPM4 activated the JAK1/STAT1 pathway, developed abnormal DNA damage response (DDR), and promoted GC radioresistance. Moreover, silencing FOLR1 increased sensitivity to ionizing radiation both in vitro and in vivo. Overall, FOLR1 is a novel biomarker for GC radioresistance and provides a potential therapeutic target for overcoming radioresistance in GC patients.
Exopolysaccharides extracted from submerged cultures of Ganoderma lucidumactivate the NLRP3 inflammasome
Authors: Burguel Pedro Henrique , Castro Raffael Junio de Almeida , Basso Angelina M. Moreschi , Coutinho Luisa Coelho , Marina Clara Luna Freitas , Siqueira Isaque Medeiros , Gonzales Alysia Gonzales , Kucheryavy Pavel , Pomin Vitor H , Carbonero Elaine Rosecher , Tavares Aldo Henrique , Bocca Anamelia Lorenzetti 
Published: September 2024

Abstract

Interleucin-1β (IL-1β) is a pivotal cytokine in pro-inflammatory response induction, and it is regarded as protective in various diseases. IL-1β secretion is mainly associated with activation of the inflammasome complex, which generally is tightly regulated, depending on two signals for significant activity. The water-insoluble fraction of the mushroom Ganoderma lucidum was extracted and co-cultivated with murine bone marrow macrophages. We demonstrated that G. lucidum exopolysaccharides (EPS) could induce IL-1β production and release in murine macrophages. The mechanisms underlying EPS-induced priming encompass recognition through dectin-1 and activation of the spleen tyrosine kinase (Syk) / nuclear factor kappa-light-chain-enhancer of the activated B (NF-kB) axis. In addition, EPS stimulates IL-1β secretion in a phagocytosis-dependent manner via the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in response to reactive oxygen species production, potassium efflux, phagolysosomal acidification, and cathepsin B release. Both caspase-1 and, to a lesser extent, caspase-8 were activated upon EPS stimulus and required for IL-1β cleavage and release. The treatment with EPS by gavage of Cryptococcus neoformans-infected mice showed increased survival. Our study highlighted significant stimulation by G. lucidum EPS to innate immune cells, suggesting a potential adjuvant in antimicrobial treatment schemes.
Community Scientists Fill Gaps in Knowledge Generation, Education, and Enforcement in Social-Ecological Systems
Authors: O'Connor Ryan , De Leo Giulio , Ardoin Nicole 
Published: September 2024

Abstract

Community scientists play a critical role in developing, interpreting, and sharing the science needed to understand complex human and ecological systems. In this paper, we present a novel framework for analyzing the complex interactions of community scientists, highlighting their vital role in filliing capacity gaps throughout social-ecological systems. Our framework identifies three key boundaries spanned by community scientists: knowledge generation, education, and enforcement. We further show that these boundary spanning roles emerge in response to limitations in the capacity of institutions. Community scientists provide valuable support to institutions by acting as “eyes and ears,” augmenting and supporting the activities of government agencies throughout social-ecological systems. We empirically support this framework through a case study of a coastal community in California, USA. By emphasizing the diverse ways community scientists' engage with their communities, our framework provides a foundation for more effective integration of their efforts in environmental research and policy. We also highlight the need for careful consideration of the ethical and practical implications of relying on community scientists to accommodate gaps in institutional capacity. This study advances our understanding of community science and offers broadly applicable insights for improving collaborative approaches to social-ecological challenges across scales and systems.
The clinical evaluation of the effect of traditional attachment and optimized attachment on maxillary teeth movement in patients with extracted first premolar teeth
Authors: Shen Tao , Xie Piao , Guo Mengying , Shi Qun , Hong Xinyu , Hu Xin , Liu Jian 
Published: September 2024

Abstract

Background: The purpose of this study was to compare the effects of G6 optimized attachment and traditional attachment on maxillary teeth movement in patients with first premolar extraction.
Methods: In this study, 29 patients who received 4 first premolar extraction treatment with Invisalign (Align Technology) and completed the first series of aligners were included. Superimposition of pretreatment and predicted posttreatment dental models was acquired from ClinCheck software. By superimposing skull models and dental models, the final superimposition of the pretreatment and posttreatment dental models were obtained. Posttreatment and predicted posttreatment three-dimensional teeth movements of the maxillary central incisors, canines, second premolars and first molars were compared between the two groups using paired t-tests, respectively, and the differences between two groups were compared using independent samples t-tests.
Results: Compared to the predicted changes, the maxillary central incisors achieved greater distal rotation and palatal inclination and extrusion. The maxillary canines achieved greater distal rotation, distal tipping and extrusion. The maxillary second premolars achieved less distal tipping and intrusion. The maxillary first molars achieved greater buccal inclination and less distal tipping and intrusion. For the comparison of teeth movement achieved between the two groups, there was a significant difference in changes in torque and buccolingual displacement of the maxillary central incisors and angulation of the maxillary canines between the traditional attachment group and the G6 optimized attachment group.
Conclusions: There are differences between traditional attachments and G6 optimized attachments in controlling the torque and buccolingual displacement of the maxillary central incisors, as well as the axial angulation of the canines.
Feasibility and reproducibility of speckle tracking echocardiography in routine assessment of the fetal heart in a low-risk population
Authors: Sacco Adalina , Kazi Ayisha , Nzelu Diane , Jowett Victoria , Pandya Pranav 
Published: September 2024

Abstract

Background Assessment of fetal cardiac function can now be undertaken with speckle tracking echocardiography (STE) in a variety of settings. The objective of this study was to evaluate the feasibility and reproducibility of STE in routine fetal cardiac assessments by non-experts in an NHS clinical setting.Methods A prospective longitudinal cohort study was performed from April 2022 to June 2023. For all women attending for ultrasound scan between 18 and 40 weeks’ gestation a three second cineloop of the fetal four chamber view stored if technically possible. Parameters of global cardiac function (ejection fraction [EF], cardiac output [CO], cardiac output per kg [CO/kg], stroke volume [SV] and stroke volume/kg [SV/kg], and fractional area change of the ventricles [FAC]) were analysed off-line using STE software by two researchers independently.Results Of 393 ultrasound scans performed in fetuses fulfilling criteria, 50.9% were able to be analysed using STE. Intraobserver variability was poor to moderate for both operators (Operator 1 correlation coefficient for FAC 0.28, EF 0.17, SV 0.01, SV/Kg 0.00, CO 0.74, CO/Kg 0.39; Operator 2 correlation coefficient for FAC 0.58, EF 0.65, SV 0.67, SV/Kg 0.02, CO 0.66, CO/Kg 0.31). Interobserver variability was also poor to moderate (Operator 1 vs Operator 2 correlation coefficient for FAC 0.01, EF 0.00, SV 0.00, SV/Kg 0.00, CO 0.64, CO/Kg 0.25; Operator 2 vs Operator 1 correlation coefficient for FAC 0.16, EF 0.06, SV 0.72, SV/Kg 0.008, CO 0.70, CO/Kg 0.34).Conclusion Routine speckle tracking echocardiography of global cardiac function in low-risk fetuses has low to moderate feasibility and reproducibility in a real-world NHS setting. A high grade of expertise is likely necessary to use STE in order to achieve high reproducibility. Future research should investigate factors contributing to variability in STE measurements and standardisation of protocols.
Impact of food behavior and nutritional intake on the health status of hemodialysis patients
Authors: N Syedali Fathima , K Merina Elizabeth  Joseph , KN Preethi , Abraham Georgi , D Anandhi 
Published: September 2024

Abstract

This study was done to compare the food behavior and nutritional intake between well-nourished and malnourished Hemodialysis (HD) patients. The study included 94 samples, on hemodialysis for at least 2 months. The study is done using proforma and questionnaire. Out of 94 selected HD patients, there were 46.8% well nourished, 50% mild to moderately malnourished and 3.2% severely malnourished. There was a positive impact on health status of the HD patients based on the number of meals taken in a day and inclusion of food groups such as pulses, egg, meat, other vegetables and fruits. Vintage of Dialysis had a significant difference on the nutritional status. The mean ± SD of energy, protein, fat and carbohydrate intake by the HD patients were 1386.72 ± 353.13 kcal/day, 43.67 ± 11.53 g/day, 32.85 ± 9.11 g/day and 213.81 ± 49.45 g/day. There is a statistically significant difference in the health status of HD patients based on the intake of calories, fat and carbohydrate. The study shows no statistically significant difference among the three different health groups based on the consumption of protein. The present study shows that there is a positive influence of food behavior and nutritional intake on hemodialysis patient’s health status.
Prognostic impact of expression of CD2, CD25, and/or CD30 in/on mast cells in
systemic mastocytosis: a registry study of the ECNM
Authors: Rüfer Axel , Nilius Henning , Hermine Oliver , Niedoszytko Marek , Elberink Hanneke Oude , Bonadonna Patrizia , Shoumariyeh Khalid , Gulen Theo , Hartmann Karin , Sabato Vito , Angelova-Fischer Irena , Baffoe Daniel , Fortina Anna Belloni , Breynaert Christine , Brockow Knut , von Bubnoff Nikolas , Bumbea Horia , Daele Paul van , Doubek Michael , Dybedal Ingunn , ELENA CHIARA , Fokoloros Christos , Górska Aleksandra , Heizmann Marc , Jentzsch Madlen , Luebcke Johannes , Mattsson Mattias , Panse Jens , Shug Tanja , Sciumè Mariarita , Stefan Alex , Sztormowska Marlena , Várkonyi Judit , Wortmanns Friederike , Yavuz Akif , Sperr Martina , Gotlib Jason , Reiter Andreas , Triggiani Massimo , Sperr Wolfgang , Valent Peter 
Published: September 2024

Abstract

Expression of CD2, CD25 and/or CD30 in extracutaneous mast cells (MC) is a minor diagnostic criterion for systemic mastocytosis (SM) in the classification of the World Health Organization and International Consensus Classification. So far, it remains unknown whether expression of these antigens on MC is of prognostic significance in SM. We performed a retrospective multi-center study of patients with SM using the data set of the registry of the European Competence Network on Mastocytosis, including 5034 patients with various MC disorders. The percentage of CD2-, CD25+ and/or CD30+ MC was considerably lower in patients with indolent SM compared to patients with advanced SM, including aggressive SM and MC leukemia. Whereas CD25 and CD30 expres-sion in MC could not be associated with prognosis, we found that lack of CD2 expression in MC is associated with a significantly reduced overall survival (OS) in patients with SM (p<0.0001). Lack of CD2 was also associated with the presence of extramedullary involvement affecting the spleen, liver, and/or lymph nodes (odds ratio 2.63 compared to SM with CD2+ MC). Together, lack of CD2 expression in MC is an important prognostic marker and indicator of reduced OS and extramedul-lary disease expansion in patients with SM.