bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dexamethasone and High-Dose Methotrexate Improve Outcome for Children and Young Adults With High-Risk B-Acute Lymphoblastic Leukemia: A Report From Children’s Oncology Group Study AALL0232
Authors: Larsen Eric C. , Devidas Meenakshi , Chen Si , Salzer Wanda L. , Raetz Elizabeth A. , Loh Mignon L. , Mattano Leonard A. , Cole Catherine , Eicher Alisa , Haugan Maureen , Sorenson Mark , Heerema Nyla A. , Carroll Andrew A. , Gastier-Foster Julie M. , Borowitz Michael J. , Wood Brent L. , Willman Cheryl L. , Winick Naomi J. , Hunger Stephen P. , Carroll William L. 
Published: April 2016

Purpose Survival for children and young adults with high-risk B-acute lymphoblastic leukemia has improved significantly, but 20% to 25% of patients are not cured. Children’s Oncology Group study AALL0232 tested two interventions to improve survival. Patients and Methods Between January 2004 and January 2011, AALL0232 enrolled 3,154 participants 1 to 30 years old with newly diagnosed high-risk B-acute lymphoblastic leukemia. By using a 2 × 2 factorial design, 2,914 participants were randomly assigned to receive dexamethasone (14 days) versus prednisone (28 days) during induction and high-dose methotrexate versus Capizzi escalating-dose methotrexate plus pegaspargase during interim maintenance 1. Results Planned interim monitoring showed the superiority of the high-dose methotrexate regimens, which exceeded the predefined boundary and led to cessation of enrollment in January 2011. At that time, participants randomly assigned to high-dose methotrexate during interim maintenance 1 versus those randomly assigned to Capizzi methotrexate had a 5-year event-free survival (EFS) of 82% versus 75.4% (P = .006). Mature final data showed 5-year EFS rates of 79.6% for high-dose methotrexate and 75.2% for Capizzi methotrexate (P = .008). High-dose methotrexate decreased both marrow and CNS recurrences. Patients 1 to 9 years old who received dexamethasone and high-dose methotrexate had a superior outcome compared with those who received the other three regimens (5-year EFS, 91.2% v 83.2%, 80.8%, and 82.1%; P = .015). Older participants derived no benefit from dexamethasone during induction and experienced excess rates of osteonecrosis. Conclusion High-dose methotrexate is superior to Capizzi methotrexate for the treatment of high-risk B-acute lymphoblastic leukemia, with no increase in acute toxicity. Dexamethasone given during induction benefited younger children but provided no benefit and was associated with a higher risk of osteonecrosis among participants 10 years and older.
Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia
Authors: Liu Chengcheng , Yang Wenjian , Devidas Meenakshi , Cheng Cheng , Pei Deqing , Smith Colton , Carroll William L. , Raetz Elizabeth A. , Bowman W. Paul , Larsen Eric C. , Maloney Kelly W. , Martin Paul L. , Mattano Leonard A. , Winick Naomi J. , Mardis Elaine R. , Fulton Robert S. , Bhojwani Deepa , Howard Scott C. , Jeha Sima , Pui Ching-Hon , Hunger Stephen P. , Evans William E. , Loh Mignon L. , Relling Mary V. 
Published: April 2016

Purpose Acute pancreatitis is one of the common causes of asparaginase intolerance. The mechanism is unknown, and genetic predisposition to asparaginase-induced pancreatitis has not been previously identified. Methods To determine clinical risk factors for asparaginase-induced pancreatitis, we studied a cohort of 5,185 children and young adults with acute lymphoblastic leukemia, including 117 (2.3%) who were diagnosed with at least one episode of acute pancreatitis during therapy. A genome-wide association study was performed in the cohort and in an independent case-control group of 213 patients to identify genetic risk factors. Results Risk factors associated with pancreatitis included genetically defined Native American ancestry (P < .001), older age (P < .001), and higher cumulative dose of asparaginase (P < .001). No common variants reached genome-wide significance in the genome-wide association study, but a rare nonsense variant rs199695765 in CPA2, encoding carboxypeptidase A2, was highly associated with pancreatitis (hazard ratio, 587; 95% CI, 66.8 to 5166; P = 9.0 × 10−9). A gene-level analysis showed an excess of additional CPA2 variants in patients who did versus those who did not develop pancreatitis (P = .001). Sixteen CPA2 single-nucleotide polymorphisms were associated (P < .05) with pancreatitis, and 13 of 24 patients who carried at least one of these variants developed pancreatitis. Biologic functions that were overrepresented by common variants modestly associated with pancreatitis included purine metabolism and cytoskeleton regulation. Conclusion Older age, higher exposure to asparaginase, and higher Native American ancestry were independent risk factors for pancreatitis in patients with acute lymphoblastic leukemia. Those who inherit a nonsense rare variant in the CPA2 gene had a markedly increased risk of asparaginase-induced pancreatitis.
Secular Changes in Postfracture Outcomes Over 2 Decades in Australia: A Time-Trend Comparison of Excess Postfracture Mortality in Two Birth Controls Over Two Decades
Authors: Bliuc Dana , Tran Thach , Alarkawi Dunia , Nguyen Tuan V. , Eisman John A. , Center Jacqueline R. 
Published: April 2016

Abstract

Context:
Hip fracture incidence has been declining and life expectancy improving. However, trends of postfracture outcomes are unknown.

Objectives:
The objective of the study was to compare the refracture risk and excess mortality after osteoporotic fracture between two birth cohorts, over 2 decades.

Design:
Prospective birth cohorts were followed up over 2 decades (1989–2004 and 2000–2014).

Setting:
The study was conducted in community-dwelling participants in Dubbo, Australia.

Participants:
Women and men aged 60–80 years, participating in Dubbo Osteoporosis Epidemiology Study 1 (DOES 1; born before 1930) and Dubbo Osteoporosis Epidemiology Study 2 (DOES 2; born after 1930) participated in the study.

Main Outcome Measure:
Age-standardized fracture and mortality over two time intervals: (1989–2004 [DOES 1] and 2000–2014 [DOES 2]) were measured.

Results:
The DOES 2 cohort had higher body mass index and bone mineral density and lower initial fracture rate than DOES 1, but similar refracture rates [age-standardized refracture rates per 1000 person-years: women: 53 (95% confidence interval [CI] 42–63) and 51 (95% CI 41–60) and men: 53 (95% CI 38–69) and 55 (95% CI 40–71) for DOES 2 and DOES 1, respectively). Absolute postfracture mortality rates declined in DOES 2 compared with DOES 1, mirroring the improvement in general-population life expectancy. However, when compared with period-specific general-population mortality, there was a similar 2.1- to 2.6-fold increased mortality risk after a fracture in both cohorts (age-adjusted standardized mortality ratio, women: 2.05 [95% CI 1.43–2.83] and 2.43 [95% CI 1.95–2.99] and men: 2.56 [95% CI 1.78–3.58] and 2.48 [95% CI 1.87–3.22] for DOES 2 and DOES 1, respectively).

Conclusion:
Over the 2 decades, despite the decline in the prevalence of fracture risk factors, general-population mortality, and initial fracture incidence, there was no improvement in postfracture outcomes. Refracture rates were similar and fracture-associated mortality was 2-fold higher than expected. These data indicate that the low postfracture treatment rates are still a major problem.
The Revolution on Trial: Assassination, Christianity, and the Rule of Law in 1920s Mexico
Authors: Weis Robert 
Published: April 2016

AbstractThe 1928 trial of José de León Toral, assassin of Mexican caudillo Álvaro Obregón, afforded President Plutarco Elías Calles the opportunity to show domestic and international audiences that the revolution had yielded a nation of laws predicated on spiritual principles. Summary executions of Catholics had allowed detractors and even sympathetic observers to question the depth of civic values in Mexico. The article shows how authorities deliberately presented the hearing as the concrete realization of Calles's claim that his administration had established institutions that embodied the principles of the revolution. Although the Christian idioms presented by the prosecution support recent scholarly arguments regarding deist tendencies within revolutionary ideologies, this article points out that the government's emphasis on its spiritual conviction sought to bolster the claim that anticlericalism was not antireligious but rather necessary for the rule of law.
A Division of Listening: Insurgent Sympathy and the Sonic Broadcasts of the Thai Military
Authors: Tausig Benjamin 
Published: April 2016

During ten weeks of antigovernment protest in spring 2010, the Thai military used physical and psychological tactics, including coercive broadcasting of music and sound, to combat demonstrations in Bangkok. Before a violent crackdown in May, protesters and soldiers spent ten weeks in a standoff in which such broadcasting figured crucially. An analysis of sound and its reception during those weeks reveals the precarious status of nationalism in a country where other political loyalties, including regionalism and class, have come increasingly (and in this case study, audibly) to the fore.
The army's sonic broadcasting unit was successfully attuned to the regional ear of the largely rural protesters; however, the army may have been winning the battle even as the state was losing the war. The broadcasting unit had its greatest success playing rural-inflected genres like mor lam and luk thung, even as protesters failed to respond to broadly patriotic songs and gestures. The primary locus of sympathetic listening had become local or regional rather than national. I refer to this mode of listening as one of “insurgent sympathy,” an indirect entry point for class-based alliances otherwise impossible in Thai political life.
The expanding regulatory universe of p53 in gastrointestinal cancer
Authors: Fesler Andrew , Zhang Ning , Ju Jingfang 
Published: April 2016

Tumor suppresser geneTP53is one of the most frequently deleted or mutated genes in gastrointestinal cancers. As a transcription factor, p53 regulates a number of important protein coding genes to control cell cycle, cell death, DNA damage/repair, stemness, differentiation and other key cellular functions. In addition, p53 is also able to activate the expression of a number of small non-coding microRNAs (miRNAs) through direct binding to the promoter region of these miRNAs. Many miRNAs have been identified to be potential tumor suppressors by regulating key effecter target mRNAs. Our understanding of the regulatory network of p53 has recently expanded to include long non-coding RNAs (lncRNAs). Like miRNA, lncRNAs have been found to play important roles in cancer biology. With our increased understanding of the important functions of these non-coding RNAs and their relationship with p53, we are gaining exciting new insights into the biology and function of cells in response to various growth environment changes. In this review we summarize the current understanding of the ever expanding involvement of non-coding RNAs in the p53 regulatory network and its implications for our understanding of gastrointestinal cancer.
Particular Models of Options Planning of Promotional Campaigns
Authors: Поляков  , Polyakov V. , Фомичева  , Fomicheva Irina 
Published: April 2016

The concept of advertising stream as a kinematic characteristic in media planning
is given. The classification of advertising streams from the standpoint of deciduous
interval. The analysis of stream models of advertising campaign is presented.
Particular qualities of streams depending on the types of structural compositions
of advertising campaigns are showed. Conflicting situations in optimizing the
process of media planning of an advertising campaign is considered.
Temporal Profiles of Instant Utility During Anticipation, Event, and Recall
Authors: Baucells Manel , Bellezza Silvia 
Published: April 2016

We propose the anticipation-event-recall (AER) model. Set in a continuous time frame, the AER model formally links the three components of total utility (i.e., utility from anticipation, event utility, and utility from recall). The AER model predicts the temporal profiles of instant utility experienced before, during, and after a given event. Total utility is calculated as the integral of instant utility. The model builds on the psychological elements of conceptual consumption, adaptation, and time distance. By virtue of its rich formulation, the AER model produces a wide set of insights and testable predictions, including the U shape of instant utility during anticipation and the optimal duration of anticipation for a given event. Using both real and hypothetical events, we provide empirical evidence in support of the main implications of the AER model. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2362 . This paper was accepted by James Smith, decision analysis.
Intimal Flap Vegetation Following Aortic Root Re-dissection
Authors: Osada Hiroaki , Nakajima Hiroyuki , Meshii Katsuaki , Ohnaka Motoaki 
Published: April 2016

AbstractA 75-year-old man who had undergone ascending aorta replacement for acute Type A aortic dissection presented with a recurring high fever. Transesophageal echocardiography revealed that a vegetation had formed on the re-dissected intimal flap of the noncoronary sinus of Valsalva. This didactic case suggests that antibiotic prophylactic measures be considered for aortic dissection flaps as for irregular valves susceptible to infective endocarditis.
Anomalous Origin of the Left Vertebral Artery from the Aortic Arch
Authors: Einstein Evan , Song Linda , Villela Natalia , Fasani-Feldberg Gregory , Jacobs Jonathan , Kim Dolly , Nathawat Akshay , Patel Devika , Bender Roger , Peters Daniel 
Published: April 2016

AbstractAnatomic anomalies of the aortic arch have implications for clinical practice if their significance is understood. Our case study involves a cadaveric finding of the left vertebral artery originating directly from the aortic arch. Although this anatomical variation has been documented, the prevalence of this anomaly may be generally underestimated. After noting this anomaly, we analyzed 27 cases and found that four female cadavers had the left vertebral artery originating from the aortic arch rather than the left subclavian artery. With a prevalence rate of 14.8%, it would seem that this anomaly is more significant than previously thought, which could have implications for surgical practice.
Impact of High-Sensitivity Troponin I Testing with Sex-Specific Cutoffs on the Diagnosis of Acute Myocardial Infarction
Authors: Trambas Christina , Pickering John W , Than Martin , Bain Chris , Nie Lucy , Paul Eldho , Dart Anthony , Broughton Arch , Schneider Hans Gerhard 
Published: April 2016

Abstract

BACKGROUND
High-sensitivity cardiac troponin I (hs-cTnI) assays show sex-dependent differences in the 99th percentile of healthy populations, with concentrations in women approximately 50% lower. The adoption of sex-specific cutoffs seems appropriate, although it is not yet clear what effect these will have on acute myocardial infarction (AMI) diagnosis and management.

METHODS
We conducted a retrospective pre- and postchangeover analysis of troponin I testing in the 6 months before and after moving from the contemporary Abbott Architect TnI assay (cTnI) to hs-cTnI at 2 tertiary centers in Australia and New Zealand. The cTnI cutoff was 30 ng/L for both sexes, whereas a female-specific cutoff of 16 ng/L was adopted upon changeover to hsTnI.

RESULTS
Changeover from the cTnI assay to the hs-cTnI assay increased the number of female patients with increased troponin I concentrations at both sites (from 29.7% to 34.9% and from 22.4% to 30.8%; P &lt; 0.001). There was no statistically significant change in the number of men with increased concentrations in the same time period (P = 0.09). The increased percentage of women with increased troponin I was not associated with an increase in the number of women with AMI diagnoses at either center. Angiographic data available from 1 center showed no change in the percentage of angiograms performed in women.

CONCLUSIONS
Although increasing the proportion of women with increased troponin I, adopting sex-specific cutoffs with the hs-cTnI assay did not lead to an increase in AMI diagnoses in females, or in the number of women undergoing angiography.
Knowledge licensing in a model of R&D-driven endogenous growth
Authors: Jerbashian Vahagn 
Published: April 2016

AbstractI model knowledge (patent) licensing and evaluate intellectual property regulation in an endogenous growth framework where the engine of growth is in-house R&D performed by high-tech firms. I show that high-tech firms innovate more and economic growth is higher when there is knowledge licensing, and when intellectual property regulation facilitates excludability of knowledge, than when knowledge is not excludable and there are knowledge spillovers among high-tech firms. However, the number of high-tech firms is lower, and welfare is not necessarily higher when there is knowledge licensing than when there are knowledge spillovers.
On Asymptotic Theory of Beams, Plates and Shells
Authors: Aghalovyan L.A. , Aghalovyan M.L. 
Published: April 2016

AbstractBases of asymptotic theory of beams, plates and shells are stated. The comparison with classic theory is conducted. New classes of thin bodies problems, for which hypotheses of classic theory are not applicable, are considered. By the asymptotic method effective solutions of these problems are obtained. The effectiveness of the asymptotic method for finding solutions of as static, as well as dynamic problems of beams, plates and shells is shown.
Influence of locational states of submicron fibers added into matrix on mechanical properties of plain-woven Carbon Fiber Composite
Authors: Kumamoto Soichiro , Okubo Kazuya , Fujii Toru 
Published: April 2016

AbstractThe aim of this study was to show the influence of locational states of submicron fibers added into epoxy matrix on mechanical properties of modified plane-woven carbon fiber reinforced plastic (CFRP). To change the locational states of submicron fibers, two kinds of fabrication processes were applied in preparing specimen by hand lay-up method. Submicron fibers were simply added into epoxy resin with ethanol after they were stirred by a dispersion process using homogenizer to be located far from the interface between reinforcement and matrix. In contrast, submicron fibers were attached onto the carbon fibers by injecting from a spray nozzle accompanying with ethanol to be located near the interface, after they were tentatively contained in ethanol. The plain-woven CFRP plates were fabricated by hand lay-up method and cured at 80 degree-C for 1 hour and then at 150 degree-C for 3 hours. After curing, the plain-woven CFRP plates were cut into the dimension of specimen. Tensile shear strength and Mode-II fracture toughness of CFRP were determined by tensile lap-shear test and End-notched flexure(ENF) test, respectively. When submicron fibers were located far from the interface between carbon fibers and epoxy resin, tensile shear strength and Mode-II fracture toughness of CFRP were improved 30% and 18% compared with those of unmodified case. The improvement ratio in modified case was rather low (about few percentages) in the case where submicron fibers were located near the interface. The result suggested that crack propagation should be prevented when submicron fibers were existed far from the interface due to the effective stress state around the crack tip.
Influence of phthalocyanine pigments on the properties of flame-retardant elastomeric composites based on styrene-butadiene or acrylonitrile-butadiene rubbers
Authors: Żaczek Szymon , Pająk Agnieszka , Anyszka Rafał , Janowska Grażyna 
Published: April 2016

Abstract
A study about the influence of the impartment of phthalocyanine pigments into elastomeric composites was conducted. Acrylonitrile-butadiene (NBR) and styrene-butadiene (SBR) rubbers crosslinked by either sulfur or dicumyl peroxide were filled with non-toxic flame retardants (Mg(OH)2 or Al(OH)3) and thermally stable pigments (zinc or chloroaluminum phthalocyanines). Determination of cross-linking degree, mechanical properties, aging coefficient, thermal analysis (TG, DTG, DTA) and flammability tests (oxygen index, combustion in air) were carried out. The addition of the pigments, apart from the impartment of blue or blue-green color to elastomeric composites, in numerous cases improved their mechanical properties, thermal stability, limited flammability and allowed obtaining self-extinguishing materials in atmospheric air.
Using standoff properties for marking-up historical documents in the humanities
Authors: Schmidt Desmond Allan 
Published: April 2016

Abstract
Markup in the form of tags is often embedded into documents to describe formatting structures and other features, as in HTML on the
Web. But in the humanities, the use of embedded markup for the transcription of historical documents leads to problems in the
representation of overlapping features, and subjective variation in the use of different markup tags for the same features compromises
interoperability of the transcriptions. “Standoff” techniques, in which the markup and the text it describes are stored separately, can
help alleviate these problems. “Standoff properties” is a technique for recording textual properties that do not conform to
a context-free grammar, and can freely overlap. This allows a divide-and-conquer approach to markup, whereby sets of markup properties
can record different aspects of a text, which can then be recombined as needed. Despite these advantages, standoff techniques are
usually considered impractical when both the underlying text and its markup are subject to change. To circumvent this problem, this
paper describes a practical algorithm for updating a set of standoff markup properties separately from the text.
Wikidition: Automatic lexiconization and linkification of text corpora
Authors: Mehler Alexander , Gleim Rüdiger , vor der Brück Tim , Hemati Wahed , Uslu Tolga , Eger Steffen 
Published: April 2016

Abstract
We introduce a new text technology, called Wikidition, which automatically generates large
scale editions of corpora of natural language texts. Wikidition combines a wide range of
text mining tools for automatically linking lexical, sentential and textual units. This
includes the extraction of corpus-specific lexica down to the level of syntactic words and
their grammatical categories. To this end, we introduce a novel measure of text reuse and
exemplify Wikidition by means of the capitularies, that is, a corpus of Medieval Latin
texts.