bluuebunny/crossref_metadata_2025_split huggingface dataset:
Financial Toxicity of Long‐Term Survivors Who Underwent Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma
Authors: Muaddi Hala , Zironda Andrea , Zhang Chi , Day Courtney , Starlinger Patrick P. , Warner Susanne G. , Smoot Rory L. , Kendrick Michael L. , Cleary Sean P. , Truty Mark J. , Thiels Cornelius A. 
Published: September 2024

ABSTRACTBackgroundPancreatoduodenectomy (PD) for pancreatic cancer has a profound impact on patients' lives. However, the long‐term financial implications are poorly understood.ObjectiveAssess the financial burden of long‐term survivors who underwent PD.MethodsPatients who underwent PD between January 2011 and June 2019 were identified. To evaluate the long‐term financial burden, patients surviving ≥ 3 years post‐resection were prospectively surveyed using the Comprehensive Score for financial Toxicity (COST‐FACIT) and a customized institutionally developed questionnaire. A logistic regression model predicting high financial toxicity was used to identify predictive factors.ResultsAmong 238 eligible patients, 137 (57.6%) responded. Responders had a median age of 66 (59–73) years, with 86.7% identifying as financial prosperous or comfortable. However, 33.3% experienced financial distress due to treatment costs, 27.3% demonstrated high financial toxicity on the COST‐FACIT survey, and 37.2% made sacrifices to afford treatment. Only 8.9% stated that the treatment costs influenced their decisions, and the majority (85.9%) did not discuss financial implications with healthcare providers. Multivariable analysis identified younger age as a risk factor for high financial toxicity.ConclusionOne in three long‐term survivors experienced high financial toxicity, with younger age being a predictor. This emphasizes the need for efforts to provide comprehensive support and guidance to patients to navigate their oncological journey.
The changes of vegetation community characteristics led to the reconstruction of soil microbial communities and functions during the cultivation of degraded alpine meadows
Authors: Yin Yali , Zhao Wen , Su Shifeng , Dong Yiling , Li Shixiong 
Published: September 2024

AbstractUnreasonable grassland use has degraded the alpine meadow on the Qinghai‐Tibetan Plateau in the past half a century, and approximately 32.1% of the degraded meadows degenerated to bare grassland. Artificial grassland reconstruction is a widespread measure for rebuilding the grassland ecosystems of these bare grasslands. However, does the soil microbe community structure improve with the aboveground vegetation restoration? Which microflora are more sensitive to environmental changes are not unclear. Thus, we analyzed four artificial grasslands established for different years on extreme‐degraded (ED) grasslands of the alpine meadows. These artificial grasslands were rationally utilized by grazing Tibetan sheep and Yak from December to April and were completely grazing‐prohibited in other seasons. In 2017, four plots of approximately 2400 m2 for each artificial restoration grassland (3, 6, 9, and 12 years) were selected as treatments with non‐degraded (ND) and ED meadows as controls. The potential predictors and regulators for soil microbial community structures and functions in the alpine meadows were evaluated. The results showed that artificial restoration did not affect soil microbe community compositions but dramatically changed the community constructions. The bacterial community structure was more sensitive to artificial interference than fungal. Actinobacteria, Acidobacteria, and Mortierellomycota could be used as indicators of environmental changes. Compared with ED grassland, the soil microbial biomass carbon increased significantly by 29.5% and 33.7% in 6 and 9 years grasslands, respectively. The species richness and below‐ground biomass of grassland vegetation play a decisive role in soil microbial community and functional structures, while the soil water content and organic carbon, and soil elemental balance play a regulating role. Moreover, the abundance of soil bacteria with ureolysis and nitrogen fixation functions decreased significantly in grassland degradation, and soil pH played a major regulatory role. In conclusion, the vegetation and soil of artificial grasslands were in good condition after 6 years of artificial restoration. However, all the indexes declined to different degrees after 12 years of establishment, and the grassland ecosystem faced the risk of secondary degradation. The mixed sowing of many plant species with developed root systems should be adopted when artificially restoring degenerated alpine grasslands. Simultaneously, soil organic material supplementation and the balanced application of nitrogen and phosphorus fertilizers are recommended.
Assessment of a pH optode for oceanographic moored and profiling applications
Authors: Wirth Taylor , Takeshita Yuichiro , Davis Benjamin , Park Ellen , Hu Irene , Huffard Christine L. , Johnson Kenneth S. , Nicholson David , Staudinger Christoph , Warren Joseph K. , Martz Todd 
Published: September 2024

AbstractAs global ocean monitoring programs and marine carbon dioxide removal methods expand, so does the need for scalable biogeochemical sensors. Currently, pH sensors are widely used to measure the ocean carbonate system on a variety of autonomous platforms. This paper assesses a commercially available optical pH sensor (optode) distributed by PyroScience GmbH for oceanographic applications. Results from this study show that the small, solid‐state pH optode demonstrates a precision of 0.001 pH and relative accuracy of 0.01 pH using an improved calibration routine outlined in the manuscript. A consistent pressure coefficient of 0.029 pH/1000 dbar is observed across multiple pH optodes tested in this study. The response time is investigated for standard and fast‐response versions over a range of temperatures and flow rates. Field deployments include direct comparison to ISFET‐based pH sensor packages for both moored and profiling platforms where the pH optodes experience sensor‐specific drift rates up to 0.006 pH d−1. In its current state, the pH optode potentially offers a viable and scalable option for short‐term field deployments and laboratory mesocosm studies, but not for long term deployments with no possibility for recalibration like on profiling floats.
Bone‐Mimetic Osteon Microtopographies on Poly‐ε‐Caprolactone Enhance the Osteogenic Potential of Human Mesenchymal Stem Cells
Authors: Vostatek Matthias , Verin Elettra , Tamm Marvin , Rothbauer Mario , Toegel Stefan , Moscato Francesco 
Published: September 2024

AbstractThe attributes of implant surfaces are pivotal for successful osseointegration. Among surface engineering strategies, microtopography stands out as a promising approach to promote early cellular interactions. This study aims to design and craft a novel biomimetic osteon‐like surface modification and to compare its impact on human mesenchymal stem cells (hMSCs) with four established topographies: blank, inverted pyramids, protrusions, and grooves. Poly‐ε‐caprolactone samples are fabricated using 2‐photon‐polymerization and soft lithography, prior to analysis via scanning electron microscopy (SEM), water contact angle (WCA), and protein adsorption assays. Additionally, cellular responses including cell attachment, proliferation, morphology, cytoskeletal organization, and osteogenic differentiation potential are evaluated. SEM confirms the successful fabrication of microtopographies, with minimal effect on WCA and protein adsorption. Cell attachment experiments demonstrate a significant increase on the osteon‐like structure, being three times higher than on the blank. Proliferation assays indicate a fourfold increase with osteon‐like microtopography compared to the blank, while ALP activity is notably elevated with osteon‐like microtopography at days 7 (threefold increase over blank) and 14 (fivefold increase over blank). In conclusion, the novel biomimetic osteon‐like structure demonstrates favorable responses from hMSCs, suggesting potential for promoting successful implant integration in vivo.
Enhancing the Flow‐Accelerated Corrosion Resistance of X70 API Steel Through Laser Surface Melting in Synthetic Oilfield Water
Authors: T. S. Ajmal , Singh Rahul Kumar , Arya Shashi Bhushan , Kumar D. Satish 
Published: September 2024

ABSTRACTHydrodynamic flow conditions play a critical role in piping failure due to sharp variations of the Reynolds number in process and petrochemical industries. The current study aims to enhance flow‐accelerated corrosion (FAC) resistance using metallurgy of the surface by utilizing the laser surface melting (LSM) technique. The FAC behavior of API X70 steel in simulated Indian synthetic oilfield water was studied by utilizing a closed‐loop corrosion apparatus to simulate the pipeline flow. Electrochemical corrosion experiments (AC and DC methods) were conducted at a constant fluid velocity of 3 m/s in untreated and LSM‐treated samples (at 2.5 and 3.0 kW) placed at a 90° pipe elbow. Experimental results showed that LSM‐treated samples displayed enhanced resistance to FAC, attributed to changes in surface metallurgy. Additionally, it was observed that the corrosion rate varied within the pipe elbow for the different samples at different locations.
Paying less as a signal of competence
Authors: Wang TzuShuo Ryan , Stoner Jennifer L. , Min Sophia D. , Loken Barbara 
Published: September 2024

AbstractPast research suggests that cost‐saving behaviors such as couponing can trigger negative trait perceptions (e.g. that the consumer is being miserly), and consumers purchasing gifts may avoid use of coupons so as not to appear ungenerous. In contrast, we contend that cost‐saving can also send a positive signal. In five studies we show that cost‐saving enhances perceptions of consumer competence and financial management skills, which, in turn, can lead to more favorable brand perceptions. Using costly signaling theory, we further identify two boundary conditions for these signals to be perceived as genuine: (a) absence of ulterior motives (e.g., sponsored social media posts that diminish the authenticity of the signal) and (b) the presence of the quality being signaled (as higher‐class consumers are typically seen as competent). Our findings extend the scope of signaling theory to consumer behavior contexts, showing that costly signals must honestly convey positive qualities.
Modifying Polyvinylidene Chloride Resin with Fluorine Monomer and Cross‐Linking Monomers
Authors: Gao Fengjun , Zhang Zhifeng , Song Qianqian , Abo‐Dief Hala M. , Alzahrani Eman , Wang Shouyang , Liu Yan , Shao Qian , Yang Jing , Guo Zhanhu , El‐Bahy Zeinhom M. , Ge Ruixiang 
Published: September 2024

AbstractModified polyvinylidene chloride (PVDC) resin was prepared using octafluoropentyl methacrylate and trimethylolpropane trimethacrylate as modifying monomers through seeded emulsion polymerization. The successful incorporation of octafluoropentyl methacrylate into the PVDC resin was confirmed by Fourier transform infrared spectroscopy (FTIR) and X‐ray photoelectron spectroscopy (XPS) analyses. Scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and XPS were utilized to investigate the element distribution in the modified monomer emulsion and the mechanism of monomer modification. The results demonstrated that the fluorine monomer was reacted in the resin, and mainly concentrated on the surface of the resin. The addition of octafluoropentyl methacrylate and trimethylolpropane trimethacrylate improved the water resistance of the resin. Compared to unmodified PVDC resin, the contact angle of the modified PVDC resin increased from 89.46° to 109.51°, and the water resistance at room temperature increased from 120 to 500 h. Furthermore, the modified resin exhibited excellent mechanical properties, thermal stability, and storage stability.
Case report & review: Bilateral NIFTP harboring concomitant HRAS and KRAS mutation: Report of an unusual case and literature review
Authors: Brogna Marianna Rita , Collina Francesca , Chiofalo Maria Grazia , De Bartolo Debora , Montone Angela , Schiano Maria Rosaria , Del Sesto Michele , Pizza Nubia , Ferrara Gerardo 
Published: September 2024

AbstractDiagnosis and treatment of thyroid disease are affected by the wide range of thyroid cancer subtypes and their varying degrees of aggressiveness. To better describe the indolent nature of thyroid neoplasms previously classified as noninvasive follicular variant of papillary thyroid carcinoma (NI‐FVPTC), the Endocrine Pathology Society working group has recently coined the term “noninvasive follicular thyroid neoplasm with papillary‐like nuclear features” (NIFTP). The purpose of this nomenclature change is to avoid patients the distress of cancer diagnosis and to decrease the overtreatment of thyroid nodules with a RAS‐LIKE molecular profile similar to follicular adenoma. Consequently, the reclassification has a significant impact on thyroid nodule clinical care as well as histopathologic and cytopathologic diagnosis. This paper will focus on a unique case of Bilateral NIFTP harboring concomitant HRAS and KRAS mutation; we will also review the background, molecular features, and clinical implications of NIFTP as well as the factors behind the nomenclature update. It also seemed helpful to emphasize the impact of NIFTP on clinical practice to avoid overtreating nodules that could be safely managed with lobectomy alone. Actually, despite the diagnosis is postsurgery, a comprehensive preoperative evaluation may raise a suspicion of NIFTP and suggest a more careful plan for treatment. Here, we present a unique case of bilateral NIFTP after total thyroidectomy; subsequent molecular analysis revealed that the patient's right nodule harbored an isolated p.(Q61K) HRAS mutation, while the left a p.(Q61K) KRAS mutation. To the best of our knowledge, this is the first case report of this nature. The existence of simultaneous mutations highlights the occurrence of intratumoral heterogeneity (ITH) also in the context of FVPTC, which requires comprehensive investigation. The available information shows that NIFTP, identified in accordance with stringent inclusion and exclusion criteria, exhibits a very latent clinical behavior even in the face of conservative lobectomy, lacking of radioactive iodine therapy. However, it cannot be regarded as a benign lesion because there is a small but significant incidence of adverse events, such as lymph nodes and distant metastases. Currently, NIFTP can only be suspected before surgery: several efforts could be explored to identify key molecular, cytological, and ultrasonographic traits that may be helpful in raising the possibility of NIFTP in the preoperative context. Additionally, our discovery of simultaneous mutations within the same lesion strengthens the evidence of ITH even in FVPTC. Although the extent and biological impact of this phenomenon in NIFTP are still debated, a deeper understanding is essential to ensure appropriate clinical management.
Unusual Age‐Dependent Behavior of Leukocytes Telomere Length in Friedreich's Ataxia
Authors: Scarabino Daniela , Veneziano Liana , Nethisinghe Suran , Mantuano Elide , Fiore Alessia , Granata Giulia , Solanky Nita , Zanni Ginevra , Cavalcanti Francesca , Corbo Rosa Maria , Giunti Paola 
Published: September 2024

AbstractBackgroundFriedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by an expanded GAA repeat in the first intron of the FXN gene.ObjectiveThe aim of this study was to analyze leukocyte telomeres length (LTL) in FRDA to verify the possible relationships between LTL and disease progression. We investigated LTL in a cohort of FRDA biallelic patients (n = 61), heterozygous (n = 29), and age‐matched healthy subjects (n = 87).MethodsLTL was measured by real‐time polymerase chain reaction quantitative analysis (qPCR).ResultsThe results showed that before 35 years of age, leukocyte telomeres were longer in patients than in controls, whereas the reverse applies in patients above 36 years of age. Interestingly, LTL was greater than controls at any age in heterozygous subjects. This picture mirrors what has been previously observed in vitro in FRDA cultured fibroblasts, showing significantly longer telomeres at early passages because of activation of an alternative lengthening of telomeres (ALT)‐like mechanism, but showing accelerated telomere shortening as population doubling increases. GAA1 repeat length is positively correlated with the LTL and negatively correlated with the age at blood sampling. The relationship of LTL with clinical parameters (cardiomyopathy, diabetes, dependence on a wheelchair) was also analyzed. Significantly shorter leukocyte telomeres were associated with the presence of cardiomyopathy, but not with diabetes and the dependence on a wheelchair.ConclusionsOverall, the present study indicates that telomere length analysis in FRDA may be a relevant biomarker for following the stages of the disease. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Estrogen deficiency‐mediated osteoimmunity in postmenopausal osteoporosis
Authors: Yao Yao , Cai Xiaoyu , Chen Yue , Zhang Meng , Zheng Caihong 
Published: September 2024

AbstractPostmenopausal osteoporosis (PMO) is a common disease associated with aging, and estrogen deficiency is considered to be the main cause of PMO. Recently, however, osteoimmunology has been revealed to be closely related to PMO. On the one hand, estrogen deficiency directly affects the activity of bone cells (osteoblasts, osteoclasts, osteocytes). On the other hand, estrogen deficiency‐mediated osteoimmunity also plays a crucial role in bone loss in PMO. In this review, we systematically describe the progress of the mechanisms of bone loss in PMO, estrogen deficiency‐mediated osteoimmunity, the differences between PMO patients and postmenopausal populations without osteoporosis, and estrogen deficiency‐mediated immune cells (T cells, B cells, macrophages, neutrophils, dendritic cells, and mast cells) activity. The comprehensive summary of this paper provides a clear knowledge context for future research on the mechanism of PMO bone loss.
Functional Amino Acids in the Regulation of Bone and Its Diseases
Authors: Li Siying , Tian Qinglu , Zheng Liwei , Zhou Yachuan 
Published: September 2024

AbstractBone as a vigorous tissue is constantly undergoing bone remodeling. The homeostasis of bone remodeling requires combined efforts of multifarious bone cells. Amino acids (AA), known as essential components of life support, are closely related to the regulation of bone homeostasis. In recent years, the concept of functional amino acids (FAAs) has been proposed, which is defined as AA that regulate key metabolic pathways to improve health, survival, growth, development, lactation, and reproduction of organisms, to highlight their outstanding contributions in the body. In the hope of exploring new therapeutic strategies, this review focus on summarizing recent progress in the vital role of FAAs in bone homeostasis maintaining and potential implications of FAAs in bone‐related diseases, and discussing related mechanisms. The results showed that FAAs are closely related to bone metabolism and therapeutic strategy targeting FAAs metabolism is one of the future trends for bone disorders, while the explorations about possible impact of FAAs‐based diets are still limited.
Supporting the Choice for Conservative and Surgical Treatment in Female Stress Urinary Incontinence: Development and Evaluation of a Patient Decision Aid
Authors: Gerritse Maria B. E. , de Vries Marieke , The Regina , Heesakkers John P. F. A. , Lagro‐Janssen Antoine L. M. , Huub van der Vaart C. , Kluivers Kirsten B. 
Published: September 2024

ABSTRACTIntroductionMaking a treatment decision for female stress urinary incontinence (SUI) can be challenging for patients and healthcare providers. Dutch guidelines advise to counsel both pelvic floor muscle therapy and midurethral sling surgery as primary treatment options in uncomplicated moderate to severe cases. The use of a patient decision aid (PDA) can support decision‐making, reduce decisional conflict and decisional regret, and increase knowledge. The aim of this study was to develop and evaluate an online PDA for females (SUI).MethodsThis mixed‐methods study was performed in consecutive stages by a multidisciplinary working group. PDA design was based on the International Patient Decision Aids Standards (IPDAS) and on outcomes of needs assessments amongst patients and healthcare providers. Content was based on Dutch guidelines, targeted literature searches and patient information from the Dutch scientific society for gynecology. The concept version was evaluated by patients, patients' advocates, and healthcare providers.ResultsUsing the nominal group technique, the working group established the design and format of the PDA. Fifty‐six out of 58 applicable items of the IPDAS were met. The PDA contains information on the condition, advice on lifestyle adaptations, and describes surgical and nonsurgical treatment options. The option grid contains comparisons of the primary treatment options. Furthermore, value clarification exercises and narratives were included. Acceptability and usability evaluation of the concept version was performed by 15 healthcare providers, three patients, and two patients' advocates. Comments were processed in the working group, resulting in the final version of the PDA, which was supported by all assessors.ConclusionOur multidisciplinary working group developed an online PDA for women with moderate to severe SUI including conservative and surgical treatment options, based on IPDAS criteria, guidelines, scientific evidence, and needs assessments from patients and healthcare providers. This PDA is supported by patients, healthcare providers, scientific societies, and the Dutch patients' association. The next step is to evaluate and implement this PDA in daily practice.Trial RegistrationID 2014‐308.
A motion assessment method for reference stack selection in fetal brain MRI reconstruction based on tensor rank approximation
Authors: Xu Haoan , Shi Wen , Sun Jiwei , Zheng Tianshu , Xu Xinyi , Sun Cong , Yi Sun , Wang Guangbin , Wu Dan 
Published: September 2024

AbstractSlice‐to‐volume registration and super‐resolution reconstruction are commonly used to generate 3D volumes of the fetal brain from 2D stacks of slices acquired in multiple orientations. A critical initial step in this pipeline is to select one stack with the minimum motion among all input stacks as a reference for registration. An accurate and unbiased motion assessment (MA) is thus crucial for successful selection. Here, we presented an MA method that determines the minimum motion stack based on 3D low‐rank approximation using CANDECOMP/PARAFAC (CP) decomposition. Compared to the current 2D singular value decomposition (SVD) based method that requires flattening stacks into matrices to obtain ranks, in which the spatial information is lost, the CP‐based method can factorize 3D stack into low‐rank and sparse components in a computationally efficient manner. The difference between the original stack and its low‐rank approximation was proposed as the motion indicator. Experiments on linearly and randomly simulated motion illustrated that CP demonstrated higher sensitivity in detecting small motion with a lower baseline bias, and achieved a higher assessment accuracy of 95.45% in identifying the minimum motion stack, compared to the SVD‐based method with 58.18%. CP also showed superior motion assessment capabilities in real‐data evaluations. Additionally, combining CP with the existing SRR‐SVR pipeline significantly improved 3D volume reconstruction. The results indicated that our proposed CP showed superior performance compared to SVD‐based methods with higher sensitivity to motion, assessment accuracy, and lower baseline bias, and can be used as a prior step to improve fetal brain reconstruction.