bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of health recommender systems: a scoping review protocol
Authors: Ananthakrishnan Ananya , Milne-Ives Madison , Shankar Rohit , Meinert Edward 
Published: October 2024

BackgroundPeople increasingly rely on online health information for their health-related decision-making. Given the overwhelming amount of information available, the risk of misinformation is high. Health recommender systems, which recommend personalised health-related information or interventions using intelligent algorithms, have the potential to address this issue. Many such systems have been developed and evaluated individually, but there is a need to synthesise the evaluation findings to identify gaps and ensure that future recommender systems are designed to have a positive impact on health or target behaviours.ObjectiveThe purpose of this review is to provide an overview of the state of the literature evaluating health recommender systems and highlight lessons learnt, methodological considerations and gaps in current research.Methods and analysisThe review will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews and the Population, Concept, and Context frameworks. Five databases (PubMED, ACM Digital Library Full-Text Collection, IEEE Xplore, Web of Science and ScienceDirect) will be searched for studies published in English that evaluate at least one health recommender system using search terms following the themes reflecting digital health, recommendation systems and evaluations of efficacy and impact. After using EndNote 21 for initial screening, two independent reviewers will screen the titles, abstracts and full texts of the references, and then extract data from included studies related to the recommender system characteristics, evaluation design and evaluation findings into a predetermined form. A descriptive analysis will be conducted to provide an overview of the literature; key themes and gaps in the literature will be discussed.Ethics and disseminationEthical approval is not required as data will be obtained from already published sources. Findings from this study will be disseminated via publication in a peer-reviewed journal.
Multimodal prehabilitation improves functional capacity in patients with advanced ovarian cancer undergoing cytoreductive surgery
Authors: Sebio-Garcia Raquel , Celada-Castro Cristina , Arguis Maria J , Sisó Marina , Torné Aureli , Tena Beatriz , Díaz-Feijoo Berta , Martinez-Palli Graciela 
Published: October 2024

ObjectivePrehabilitation, defined as the preparatory intervention to increase patient preparedness in the lead-up to surgery, has shown a decrease in post-operative complications in various types of surgery. However, there is limited evidence in advanced ovarian cancer surgery. This study aimed to evaluate the benefits of multimodal prehabilitation in advanced ovarian cancer patients in terms of improving physical functioning, body composition, and psychological well-being during the pre-operative period.MethodsThis single-center, ambispective study included patients with advanced ovarian cancer eligible for primary or interval cytoreductive surgery. Participants attended a multimodal prehabilitation program comprising medical optimization, supervised exercise training, nutritional counseling and supplementation, and psychological support. Functional capacity, nutritional status, and psychological well-being were assessed before the start of the program and before surgery.Results62 patients were referred for the multimodal prehabilitation program from July 2019 to May 2023. Median adherence to the training program reached 75% (IQR 58–87%). 35 patients (59%) were evaluated pre-operatively. Patients attended a median of 8 (IQR 6–12) supervised exercise training sessions with no differences between those who underwent primary or interval cytoreductive surgery (p=0.80). A significant improvement was observed in functional capacity according to the 6 min walk test (mean 33.1 m, 95% CI 10.5 to 55.5) as well as in the 30 s sit-to-stand test (+3.3 repetitions, 95% CI 1.8 to 4.8), with both being above the minimal clinically important difference of 14 m and two repetitions, respectively. Patients also reported a significant decrease in depression, anxiety, and total scores of the Hospital Anxiety and Depression Scale.ConclusionsMultimodal prehabilitation in patients with advanced ovarian cancer undergoing cytoreductive surgery improves pre-operative physical functioning and decreases emotional distress. Further controlled studies with a larger sample size are warranted to corroborate improvement in functional capacity, body composition, and psychological well-being through prehabilitation programs.
Sound and Partially-Complete Static Analysis of Data-Races in GPU Programs
Authors: Liew Dennis , Cogumbreiro Tiago , Lange Julien 
Published: October 2024

GPUs are progressively being integrated into modern society, playing a pivotal role in Artificial Intelligence

and High-Performance Computing. Programmers need a deep understanding of the GPU programming model

to avoid subtle data-races in their codes. Static verification that is sound and incomplete can guarantee

data-race freedom, but the alarms it raises may be spurious and need to be validated.
In this paper, we establish a True Positive Theorem for a static data-race detector for GPU programs, i.e., a

result that identifies a class of programs for which our technique only raises true alarms. Our work builds on

the formalism of memory access protocols, that models the concurrency operations of CUDA programs. The

crux of our approach is an approximation analysis that can correctly identify true alarms, and pinpoint the

conditions that make an alarm imprecise. Our approximation analysis detects when the reported locations are

reachable (control independence, or CI), and when the reported locations are precise (data independence, or

DI), as well identify inexact values in an alarm. In addition to a True Positive result for programs that are CI

and DI, we establish the root causes of spurious alarms depending on whether CI or DI are present.
We apply our theory to introduce FaialAA, the first sound and partially complete data-race detector. We

evaluate FaialAA in three experiments. First, in a comparative study with the state-of-the-art tools, we show that

FaialAA confirms more DRF programs than others while emitting 1.9× fewer potential alarms. Importantly, the

approximation analysis of FaialAA detects 10 undocumented data-races. Second, in an experiment studying 6

commits of data-race fixes in open source projects OpenMM and Nvidia’s MegaTron, FaialAA confirmed the

buggy and fixed versions of 5 commits, while others were only able to confirm 2. Third, we show that 59.5% of

2,770 programs are CI and DI, quantifying when the approximation analysis of FaialAA is complete.
This paper is accompanied by the mechanized proofs of the theoretical results presented therein and a tool

(FaialAA) implementing of our theory.
The Evolutionary Forest of Pancreatic Cancer
Authors: Mullen Katelyn M. , Hong Jungeui , Attiyeh Marc A. , Hayashi Akimasa , Sakamoto Hitomi , Kohutek Zachary A. , McIntyre Caitlin A. , Zhang Haochen , Makohon-Moore Alvin P. , Zucker Amanda , Wood Laura D. , Myers Matthew A. , Arnold Brian J. , Zaccaria Simone , Chou Joanne F. , Capanu Marinela , Socci Nicholas D. , Raphael Benjamin J. , Iacobuzio-Donahue Christine A. 
Published: October 2024

Abstract
The genomic features of pancreatic ductal adenocarcinoma (PDAC) have been well described, yet the evolutionary contexts within which these features occur remain unexplored. We studied genome landscapes, phylogenies, and clonal compositions of 91 PDACs in relation to clinicopathologic features. There was no difference in the number of driver mutations or evolutionary timing when each mutation occurred. High truncal density, a metric of the accumulation of somatic mutations in the lineage that gave rise to each PDAC, was significantly associated with worse overall survival. Polyclonal, monoclonal, or mixed polyclonal/monoclonal metastases were identified across the cohort, highlighting multiple forms of intertumoral heterogeneity. Advanced stage and treated PDACs had higher odds of being polyclonal, whereas oligometastatic PDACs had fewer driver alterations, a lower fractional allelic loss, and increased likelihood of being monoclonal. In sum, our findings reveal novel insights into the dynamic nature of the PDAC genome beyond established genetic paradigms.

Significance:
Although the pancreatic cancer genome has been described, it has not been explored with respect to stages of diagnosis or treatment bottlenecks. We now describe and quantify the genomic features of PDAC in the context of evolutionary metrics and in doing so have identified a novel prognostic biomarker.
O desafio da agitação psicomotora na prática clínica
Authors: Mantovani Célia 
Published: October 2024

Neste artigo discutiremos aspectos clínicos no manejo da agitação psicomotora, uma condição clínica que ocorre com frequência em setores de atendimento de saúde de urgência. O manejo da agitação psicomotora pode ser desafiador para o profissional de saúde, especialmente devido aos riscos que podem estar associados, quer seja para o paciente ou para a equipe de saúde. Por esta razão, a utilização de uma tomada de decisão baseada em um protocolo passo-a-passo é de fundamental importância para o sucesso. Deve-se iniciar tendo em conta os três passos fundamentais no manejo de agitação, a saber: ambiental, atitudinal, e farmacológico. Estes passos podem ser resumidos em: resolver ou mitigar qualquer causa médica geral de base, garantir a segurança do paciente e equipe (ambiental), manejo atitudinal através de técnicas de desescalada do comportamento, e, como último recurso, intervenções farmacológicas. A segurança do profissional na aplicação destes princípios é de fundamental importância na prevenção de consequências sombrias da agitação psicomotora, como ferimentos graves e trauma emocional para pacientes e equipe de saúde, e no tratamento adequado da condição médica geral e/ou psiquiátrica que esteja precipitando a agitação.
Assessing the consistency and sensitivity of the neural correlates of narrative stimuli using functional near-infrared spectroscopy
Authors: Kolisnyk Matthew , Novi Sergio , Abdalmalak Androu , Ardakani Reza Moulavi , Kazazian Karnig , Laforge Geoffrey , Debicki Derek B. , Owen Adrian M. 
Published: October 2024

Abstract
Investigating how the brain responds to rich and complex narratives, such as engaging movies, has helped researchers study higher-order cognition in “real-world” scenarios. These neural correlates are particularly useful in populations where behavioral evidence of cognition alone is inadequate, such as children and certain patient populations. While this research has been primarily conducted in fMRI and EEG, whether functional near-infrared spectroscopy (fNIRS) can reliably detect these neural correlates at an individual level, which is required for effective use in these populations, has yet to be established. This study replicated widespread inter-subject correlations (ISCs) in the frontal, parietal, and temporal cortices in fNIRS in healthy participants when they watched part of the TV episode Bang! You're Dead and listened to an audio clip from the movie Taken. Conversely, these ISCs were primarily restricted to temporal cortices when participants viewed scrambled versions of those clips. To assess whether these results were reliable at the single-participant level, two follow-up analyses were conducted. First, the consistency analysis compared each participant’s ISCs against group results that excluded that individual. This approach found that 24 out of 26 participants in Bang! You’re Dead and 20/26 participants in Taken were statistically similar to the group. Second, the sensitivity analysis measured whether machine-learning algorithms could decode between intact conditions and their scrambled counterparts. This approach yielded balanced accuracy scores of 81% in Bang! You’re Dead and 79% in Taken. Overall, the neural correlates of narrative stimuli, as assessed by fNIRS, are reproducible across participants, supporting its broad application to clinical and developmental populations.
Distinct effects of slow and fast theta tACS in enhancing temporal memory
Authors: Wang Yuejuan , De Weerd Peter , Sack Alexander T. , van de Ven Vincent 
Published: October 2024

Abstract
Temporal memory plays a crucial role in organizing real-life events into meaningful segments. Previous research suggests that the clustering of temporally related information builds on the neural correlates of associative memory, including theta oscillations. Transcranial alternating current stimulation (tACS) provides a means of modulating theta oscillations within associative memory networks, possibly including hippocampal modulation when targeting the parietal cortex. Theta oscillations are not limited to a single frequency range, but instead, exhibit functional specialization, with slow theta (3 Hz) implicated in short-term episodic memory formation and fast theta (8 Hz) involved in spatial navigation. Our study aimed to investigate the distinct effects of slow and fast theta stimulation on temporal memory. Participants encoded visual objects paired with frame color while receiving tACS stimulation at 3 Hz, 8 Hz, or sham targeting the left parietal cortex. The frame color would change after every eight objects, establishing a context boundary with each color change. Subsequently, participants performed a timeline task to assess temporal memory performance. Results showed that slow, but not fast, theta stimulation led to an enhancement in temporal accuracy (absolute temporal error) compared to sham tACS, in support of our main hypothesis. Under sham stimulation, participants consistently underestimated the temporal position of items presented further away from boundary, compared to those presented at boundary. This finding resembled temporal compression observed during event segmentation. Interestingly, fast, but not slow, theta stimulation reduced this temporal bias (rated position–actual position). This study represents the first tACS evidence for differential contributions of slow versus fast theta to temporal memory formation in humans. We speculate that parietal theta tACS may modulate the hippocampus and facilitate temporal memory formation.
Semantic Context Effects in Picture and Sound Naming: Evidence from Event-related Potentials and Pupillometric Data
Authors: Gruner Magdalena , Widmann Andreas , Wöhner Stefan , Schröger Erich , Jescheniak Jörg D. 
Published: October 2024

Abstract
When a picture is repeatedly named in the context of semantically related pictures (homogeneous context), responses are slower than when the picture is repeatedly named in the context of unrelated pictures (heterogeneous context). This semantic interference effect in blocked-cyclic naming plays an important role in devising theories of word production. Wöhner, Mädebach, and Jescheniak [Wöhner, S., Mädebach, A., & Jescheniak, J. D. Naming pictures and sounds: Stimulus type affects semantic context effects. Journal of Experimental Psychology: Human Perception and Performance, 47, 716–730, 2021] have shown that the effect is substantially larger when participants name environmental sounds than when they name pictures. We investigated possible reasons for this difference, using EEG and pupillometry. The behavioral data replicated Wöhner and colleagues. ERPs were more positive in the homogeneous compared with the heterogeneous context over central electrode locations between 140–180 msec and 250–350 msec for picture naming and between 250 and 350 msec for sound naming, presumably reflecting semantic interference during semantic and lexical processing. The later component was of similar size for pictures and sounds. ERPs were more negative in the homogeneous compared with the heterogeneous context over frontal electrode locations between 400 and 600 msec only for sounds. The pupillometric data showed a stronger pupil dilation in the homogeneous compared with the heterogeneous context only for sounds. The amplitudes of the late ERP negativity and pupil dilation predicted naming latencies for sounds in the homogeneous context. The latency of the effects indicates that the difference in semantic interference between picture and sound naming arises at later, presumably postlexical processing stages closer to articulation. We suggest that the processing of the auditory stimuli interferes with phonological response preparation and self-monitoring, leading to enhanced semantic interference.
The Safavid Buffer: Co-Sectarian Rivalry in Early Modern Ottoman Diplomacy with Sunni Asia
Authors: Saçmalı Habib 
Published: October 2024

Abstract
This paper offers a new perspective on Ottoman-Safavid-Mughal relations in the early modern period by exploring the broader historical context of Swedish envoy Claes Rålamb’s report of the advice offered by the Ottoman chief mufti (the highest-ranking legal authority) to the court in 1657. Rålamb reported that the chief mufti had advised that the Ottoman court reject a Mughal offer to form a Sunni alliance against Iran and instead urged the court to protect the Shiʿi Safavids. By examining early modern inter-imperial Sunni relations in general and diplomatic exchange among these Muslim states between 1648 and 1656 in particular, this article challenges the prevailing narrative of sectarian differences driving political conflicts. I show that in the period following the Ottoman-Safavid peace treaty of 1639, the Ottomans regarded the Safavid state as a buffer polity that helped to secure their legitimacy against potential Sunni rivals in Central Asia and India. The article explores how a shared religious identity fueled rather than discouraged competition for legitimacy and supremacy among Sunni rulers in an increasingly interconnected early modern world, leading the Ottomans to align with their sectarian rivals.
Multisensory Integration of Native and Nonnative Speech in Bilingual and Monolingual Adults
Authors: Mohamed Riham Hafez , Ansari Niloufar , Abdeljawad Bahaa , Valdivia Celina , Edwards Abigail , Parks Kaitlyn M.A. , Rafat Yassaman , Stevenson Ryan A. 
Published: October 2024

Abstract
Face-to-face speech communication is an audiovisual process during which the interlocuters use both the auditory speech signals as well as visual, oral articulations to understand the other. These sensory inputs are merged into a single, unified process known as multisensory integration. Audiovisual speech integration is known to be influenced by many factors, including listener experience. In this study, we investigated the roles of bilingualism and language experience on integration. We used a McGurk paradigm in which participants were presented with incongruent auditory and visual speech. This included an auditory utterance of ‘ba’ paired with visual articulations of ‘ga’ that often induce the perception of ‘da’ or ‘tha’, a fusion effect that is strong evidence of integration, as well as an auditory utterance of ‘ga’ paired with visual articulations of ‘ba’ that often induce the perception of ‘bga’, a combination effect that is weaker evidence of integration. We compared fusion and combination effects on three groups ( each), English monolinguals, Spanish–English bilinguals, and Arabic–English bilinguals, with stimuli presented in all three languages. Monolinguals exhibited significantly stronger multisensory integration than bilinguals in fusion effects, regardless of the stimulus language. Bilinguals exhibited a nonsignificant trend by which greater experience led to increased integration as measured by fusion. These results held regardless of whether McGurk presentations were presented as stand-alone syllables or in the context of real words.
2. La scène de l’Hôtel de Bourgogne en 1630. L’iconographie relue au prisme de l’infographie
Authors: Rémond François 
Published: October 2024

Plus ancien théâtre fixe de la capitale, l’Hôtel de Bourgogne demeure encore mal connu en termes d’architecture. Le manque de documents chiffrés sur cette salle dans la première moitié du XVIIe siècle a conduit à un certain nombre d’interprétations divergentes quant à l’aspect et aux dimensions de ce théâtre dans son premier état. Cet article se propose d’exposer l’état actuel de la question, et de présenter un chantier en cours consacré à la reconstitution de l’espace scénique de l’Hôtel à l’époque baroque, croisant un examen minutieux de l’iconographie disponible avec les ressources de la modélisation 3D.
The Hôtel de Bourgogne, the first Parisian public playhouse, is still little known in terms of its architectural features. The lack of quantified documents for this venue in the first half of the seventeenth century has led to a number of divergent interpretations regarding the original appearance and dimensions of this theater. This article aims to expose the current state of research on this question, and to present an ongoing project devoted to the reconstitution of the stage space of the Hôtel in the Baroque period, by combining a meticulous examination of the available iconography with 3D modeling resources.
11. Les salles de spectacle nantaises jamais construites de Vigné de Vigny et Ceineray (1755–1765)
Authors: Le Goff Julien 
Published: October 2024

Avant l’inauguration du théâtre Graslin, deux architectes se chargent de dessiner des plans généraux pour la ville de Nantes : Pierre Vigné de Vigny (1690-1772) en 1755 et Jean-Baptiste Ceineray (1722-1811) en 1761. Cet article reconstitue l’histoire contrefactuelle des lieux de spectacle de Nantes en s’appuyant sur les plans conservés. Il retrace l’évolution de différents projets architecturaux depuis leurs motivations jusqu’aux raisons de leur abandon. L’étude de cas des théâtres nantais qui auraient pu exister permet de réfléchir aux moyens de conserver, valoriser et transmettre la mémoire de ces lieux de spectacle aux générations futures.
Before the inauguration of the Graslin theater, two architects took on the task of drawing general plans for the city of Nantes: Pierre Vigné de Vigny (1690-1772) in 1755 and Jean-Baptiste Ceineray (1722-1811) in 1761. This article reconstructs the counterfactual history of Nantes’ venues for the performance arts, based on plans that have been preserved. It traces the evolution of various architectural projects, from their motivations to the reasons why they were abandoned. This case study of the theaters of Nantes that could have existed allows us to reflect on how best to preserve, enhance and transmit the memory of these venues to future generations.