bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intersphincteric Resection Pushing the Envelope for Sphincter Preservation
Authors: Denost Quentin , Rullier Eric 
Published: November 2017

AbstractDuring the last 15 years, a significant evolution has emerged in the surgical treatment of rectal cancer and restoration of bowel continuity has been one of the main goals. For many years the treatment of distal rectal cancer would necessarily require an abdominoperineal resection and end colostomy. The surgical procedure of intersphincteric resection has been proposed to offer sphincter preservation in patients with low rectal cancer and has been legitimized if executed according to adequate oncologic criteria. This article will discuss the best indications, technical aspects, functional, and oncological outcomes of intersphicteric resection in the management of rectal cancer.
Differentially Regulated Cell-Free MicroRNAs in the Plasma of Friedreich's Ataxia Patients and Their Association with Disease Pathology
Authors: Dantham Subrahamanyam , Srivastava Achal , Gulati Sheffali , Rajeswari Moganty 
Published: November 2017

AbstractFriedreich's ataxia (FRDA) is a multisystem disease affecting the predominately nervous system, followed by muscle, heart, and pancreas. Current research focused on therapeutic interventions aimed at molecular amelioration, but there are no reliable noninvasive signatures available to understand disease pathogenesis. The present study investigates the alterations of plasma cell-free microRNAs (miRNAs) in FRDA patients and attempts to find the significance in relevance with the pathogenesis. Total RNA from the plasma of patients and healthy controls were subjected to miRNA microarray analysis using Agilent Technologies microarray platform. Differentially regulated miRNAs were validated by SYBR-green real-time polymerase chain reaction (Thermo Fisher Scientific). The study identified 20 deregulated miRNAs (false discovery rate < 0.01, fold change ≥ 2.0 ≤) in comparison with healthy controls; out of which 17 miRNAs were upregulated, and 3 miRNAs were downregulated. Target and pathway analysis of these miRNAs have shown association with neurodegenerative and other clinical features in FRDA. Further validation (n = 21) identified a set of significant (p < 0.05) deregulated miRNAs; hsa-miR-15a-5p, hsa-miR-26a-5p, hsa-miR-29a-3p, hsa-miR-223–3p, hsa-24–3p, and hsa-miR-21–5p in comparison with healthy controls. These miRNAs were reported to influence various pathological features associated with FRDA. The present study is expected to aid in the understanding of disease pathogenesis.
Mild Encephalitis/Encephalopathy with Reversible Splenial Lesion (MERS) due to Cytomegalovirus: Case Report and Review of the Literature
Authors: Porretti Giulia , Marchiò Giuliana , Bellizzi Maria , Recla Mauro , Feraco Paola 
Published: November 2017

AbstractMild encephalopathy with a reversible splenial lesion (MERS) is a clinico-radiological syndrome characterized by a transient mild encephalopathy and MRI findings of a reversible lesion in the splenium of corpus callosum (SCC). It is classified in MERS type I and MERS type II, depending on the involvement of SCC alone or also other white matter areas. The syndrome mainly affects children and young adults; the prognosis is favorable with complete or nearly complete neurological and radiological resolution within days or weeks. The vast majority of the cases described in the literature involve Asian and Australian children. The exact pathophysiology is unknown; however, infectious-related MERS (in particular virus associated MERS) remains the most common cause of reversible splenial lesions in childhood. To the best of our knowledge, there is only one published case of MERS associated with cytomegalovirus (CMV) infection involving an Australian child. We present here the first case of a CMV-related MERS in a European Caucasian child.
Die Arthropathie bei hereditärer Hämochromatose
Authors: Keyßer Gernot 
Published: November 2017

ZusammenfassungDie Arthropathie bei hereditärer Hämochromatose (HH) ist eine wichtige metabolische und die häufigste genetisch bedingte Gelenkerkrankung in der Rheumatologie. Ihre Manifestation ist variabel. Unbehandelt ist die Erkrankung regelhaft progredient und gibt Anlass zu Verwechslungen mit Arthrosen, rheumatoider Arthritis oder einer Chondrokalzinose aus anderer Ursache. Dank der Identifikation der wesentlichen Risikogene hat sich die Diagnostik der HH in den letzten Jahren so verbessert, dass das Vollbild mit ausgeprägter Schädigung von Leber, Pankreas und Herz seltener geworden ist. Als Therapie hat die Aderlassbehandlung nichts von ihrer Bedeutung verloren. Das Screening von Familienangehörigen Betroffener kann subklinische Fälle erkennen, bevor eine massive Eisenüberladung einsetzt.
Die Rolle des Metabolismus und metabolisch relevanter Faktoren in der Pathophysiologie rheumatischer Erkrankungen
Authors: Hülser Marie-Lisa , Frommer Klaus , Müller-Ladner Ulf 
Published: November 2017

ZusammenfassungBei der Entstehung und dem Verlauf rheumatischer Erkrankungen spielen Adipositas, Metabolisches Syndrom (MetS) und Stoffwechselerkrankungen wie Diabetes eine wichtige Rolle. Wichtige Faktoren sind hierbei Fettgewebshormone wie z. B. Adiponektin und Leptin, aber auch andere biologisch aktive Faktoren des Metabolismus, wie die freien und gebundenen Fettsäuren im Blut und die Cholesterinwerte, welche den Krankheitsverlauf von Patienten mit rheumatischen Erkrankungen beeinflussen. Sowohl für Patienten mit rheumatoider Arthritis (RA) und Psoriasis-Arthritis (PsA) als auch für die nicht autoimmun beeinflusste Arthrose stellt Adipositas einen anerkannten Risikofaktor dar und ist somit von pathophysiologischer Bedeutung. Ein Einfluss auf das Ansprechen auf Medikamente wurde ebenso beobachtet. So erreichen übergewichtige PsA-Patienten, v. a. bei vermehrtem abdominalem Fett, unter TNFα-Blocker-Therapie mit geringerer Wahrscheinlichkeit eine minimale Krankheitsaktivität. In der Pathophysiologie rheumatischer Erkrankungen ist Fettgewebe außerdem wichtig als IL-6-Produzent, da IL-6 zu etwa einem Drittel im Fettgewebe produziert wird und eine Reduktion des Körpergewichts auch zur Reduktion des Serum-IL-6-Spiegels führt. Die Interaktion zwischen Immunsystem und biologisch aktiven Faktoren aus dem Metabolismus bei entzündlichen Erkrankungen funktioniert in beide Richtungen, wodurch die Wirknetzwerke sehr komplex werden. Der Entzündungsmarker C-reaktives Protein (CRP) bspw. bindet im Serum an Leptin und verhindert dadurch dessen Wirkung bzw. die Signalweiterleitung an die Zielzellen. Gleichzeitig fördert Leptin in der Leber die Bildung von CRP. Über diese gegenseitigen Einflüsse kann vermutlich CRP die Adipositas und deren Komorbiditäten beeinflussen. Der CRP-Spiegel korreliert aber auch negativ mit den HDL-Werten, und die Lipidwerte im Blut werden durch akute oder chronische Entzündung signifikant verändert. Auch die neuen Therapieansätze mit „Small Molecules“ wie z. B. Tofacitinib wirken sich nicht nur auf die Entzündung, sondern auch auf den Metabolismus aus. So wurde gezeigt, dass Patienten mit RA signifikant niedrigere Werte an Gesamtcholesterin, HDL-C, LDL-C und Apo-A1 im Vergleich zu gesunden Kontrollen aufweisen. Diese werden aber unter Behandlung mit Tofacitinib signifikant erhöht und nähern sich somit den Werten der gesunden Kontrollgruppe an.
Can We Rely on AGNP Therapeutic Targets Also For LAI Antipsychotics?
Authors: Baldelli Sara , Clementi Emilio , Cattaneo Dario 
Published: November 2017

AbstractThe updated AGNP Consensus Guidelines for Therapeutic Drug Monitoring (TDM) in Neuropsychopharmacology recently published in the journal have reinforced the key role of TDM to individualize psychoparmacological therapies in clinical practice. However, we believe, that these guidelines have missed the important opportunity to face with, and to provide useful information on, the emerging issue of long-acting injectable formulations of atypical antipsychotics. Specific therapeutic ranges also for these formulations should be included in the next AGNP guidelines.
Prenatal stress accelerates offspring growth to compensate for reduced maternal investment across mammals
Authors: Berghänel Andreas , Heistermann Michael , Schülke Oliver , Ostner Julia 
Published: November 2017

Significance
Maternal stress during gestation causes numerous effects on infant physiology that extend well into adulthood. We contribute to the ongoing debate on whether these effects are adaptive outcomes or merely the product of energetic constraints by presenting an integrated hypothesis that predicts the diversity of observed maternal effects on offspring growth, incorporating both theoretical explanations into one coherent framework. Empirical tests of this hypothesis across mammals suggest that the timing of the stressor during gestation and a simultaneous consideration of maternal investment and adaptive growth plasticity effects are crucial for a full comprehension of prenatal stress effects on offspring growth. The results support an adaptive life history perspective on maternal effects that is relevant for evolutionary biology, medicine, and psychology.
Predicting phenological shifts in a changing climate
Authors: Scranton Katherine , Amarasekare Priyanga 
Published: November 2017

SignificanceChanges in species’ phenology, the seasonal timing of life history events, constitute one of the most unambiguous consequences of climate warming and one of the least understood. As our climate continues to warm and become more variable, we need theory that can explain the current phenological patterns and predict future changes. We present a mathematical framework that translates temperature effects on the phenotypic traits of individual organisms to the population-level phenological patterns observed in ectotherms. It is sufficiently mechanistic to yield accurate predictions and sufficiently broad to apply across ectothermic taxa. Its power lies in generating predictions based solely on life history trait responses to temperature and hence completely independent of the population-level observations of phenological changes.
In situ modeling of multimodal floral cues attracting wild pollinators across environments
Authors: Nordström Karin , Dahlbom Josefin , Pragadheesh V. S. , Ghosh Suhrid , Olsson Amadeus , Dyakova Olga , Suresh Shravanti Krishna , Olsson Shannon B. 
Published: November 2017

Significance
The coeveolution of flowers and pollinators is well known, but how generalist pollinators identify suitable flowers across environments and flower species is not well understood. Hoverflies, which are found across the globe, are one of the most important alternative pollinators after bees and bumblebees. Here we measured, predicted, and finally recreated multimodal cues from individual flowers visited by hoverflies in three different environments (hemiboreal, alpine, and tropical). We found that although “flower signatures” were unique for each environment, some cues were ubiquitously attractive, despite not resembling cue combinations from real flowers. Our results provide unique insights into how a cosmopolitan pollinator identifies flower objects across environments, which has important implications for our understanding of pollination as a global ecological service.
Politeness at the extremes
Authors: Moghaddam Mostafa Morady 
Published: November 2017

Abstract
This study addresses the issue of politeness in compliment responses (CRs) among Iranian female university students. Using naturally occurring talk, 235 compliment-response exchanges were recorded during focus group interviews. The findings revealed that to mitigate impoliteness the interviewees displayed five extreme culture-specific politeness strategies as (1) tarof, (2) shekasteh-nafsi, (3) hyperreciprocation, (4) sha’n, and (5) double positive response. In female-female CR exchanges, interviewees attempted to foster a good impression by resorting to politeness strategies of tarof, hyperreciprocation, and double positive response whereas in male-female CR exchanges, interviewees tried to undermine the appraised impression imposed by the opposite-sex compliments through politeness strategies that are anchored in sha’n and shekasteh-nafsi. This article concludes that Iranian women respond diversely to compliments by virtue of interaction among integrated components: the compliment topic, the complimenter’s sex, and cultural burdens.
Ovulation, A Sign of Health
Authors: Vigil Pilar , Lyon Carolina , Flores Betsi , Rioseco Hernán , Serrano Felipe 
Published: November 2017

The concept of the ovarian continuum can be understood as a process that occurs during a woman's lifetime and begins during intrauterine life with fertilization. Women start their reproductive years with approximately five hundred thousand follicles containing oocytes, of which only around five hundred will be released during ovulation. Ovulation has been recognized as an event linked with reproduction; however, recent evidence supports the role of ovulation as a sign of health. The use of biomarkers that help women recognize ovulation enables them to identify their health status. This knowledge helps medical healthcare providers in the prevention, diagnosis, and treatment of different pathologies related with endocrine disorders, gynecological abnormalities, autoimmune, genetic, and neoplastic diseases, as well as pregnancy-related issues. The knowledge of the ovarian continuum and the use of biomarkers to recognize ovulation should be considered a powerful tool for women and medical professionals. Summary The ovarian continuum is a process that occurs during a woman's lifetime. It begins during intrauterine life with fertilization and ends with menopause. This process can be greatly affected by different conditions such as changes in hormonal levels and illnesses. Therefore, understanding and promoting the knowledge and use of biomarkers of ovulation in women is a key aspect to consider when evaluating their health status. The knowledge and education about the ovarian continuum should be taken into account as a powerful tool for women and medical professionals.
Intergroup contact and prejudice in Moroccan and Spanish users of Spanish public libraries: mediating variables and directionality of the process / Contacto intergrupal y prejuicio en usuarios marroquíes y españoles de bibliotecas públicas españolas: variables mediadoras y direccionalidad del proceso
Authors: Cervantes Luisa , Cuadrado Isabel , Navas Marisol 
Published: November 2017

This study tests two serial models of intergroup contact in intergroup relations between users of Spanish public libraries and the directionality of the contact-prejudice relationship. Participants were selected in libraries that meet IFLA Guidelines in Barcelona ( N Spaniards = 138 and N Moroccans = 89) and libraries that do not meet these guidelines in Almería ( N Spaniards = 116 and N Moroccans = 100). They responded to a survey about the quantity of intergroup contact, anxiety, ethnocultural empathy, outgroup knowledge and prejudice. Several serial mediation analyses reveal a model where the indirect effect of quantity of contact in the library on prejudice was mediated by intergroup anxiety and ethnocultural empathy in Moroccans in Almería and Spaniards and Moroccans in Barcelona, and it found that the direction of this relationship is from contact to attitudes, but not attitudes to contact. These results show that the mediating power of affective variables is stronger than that of cognitive variables. Explanations about the absence of significant results in Spaniards in the Almería group are provided.
Methyl phenlactonoates are efficient strigolactone analogs with simple structure
Authors: Jamil Muhammad , Kountche Boubacar A , Haider Imran , Guo Xiujie , Ntui Valentine O , Jia Kun-Peng , Ali Shawkat , Hameed Umar S , Nakamura Hidemitsu , Lyu Ying , Jiang Kai , Hirabayashi Kei , Tanokura Masaru , Arold Stefan T , Asami Tadao , Al-Babili Salim 
Published: November 2017

abstract
Strigolactones (SLs) are a new class of phytohormones that also act as germination stimulants for root parasitic plants, such as Striga spp., and as branching factors for symbiotic arbuscular mycorrhizal fungi. Sources for natural SLs are very limited. Hence, efficient and simple SL analogs are needed for elucidating SL-related biological processes as well as for agricultural applications. Based on the structure of the non-canonical SL methyl carlactonoate, we developed a new, easy to synthesize series of analogs, termed methyl phenlactonoates (MPs), evaluated their efficacy in exerting different SL functions, and determined their affinity for SL receptors from rice and Striga hermonthica. Most of the MPs showed considerable activity in regulating plant architecture, triggering leaf senescence, and inducing parasitic seed germination. Moreover, some MPs outperformed GR24, a widely used SL analog with a complex structure, in exerting particular SL functions, such as modulating Arabidopsis roots architecture and inhibiting rice tillering. Thus, MPs will help in elucidating the functions of SLs and are promising candidates for agricultural applications. Moreover, MPs demonstrate that slight structural modifications clearly impact the efficiency in exerting particular SL functions, indicating that structural diversity of natural SLs may mirror a functional specificity.
A possible binary AGN in Mrk 622?
Authors: Benítez E , Rodríguez-Espinosa J M , Cruz-González I , González-Martín O , Negrete C A , Ruschel-Dutra D , Gutiérrez L , Jiménez-Bailón E 
Published: November 2017

Abstract
Mrk 622 is a Compton thick active galactic nuclei (AGN) and a double-peaked narrow emission line galaxy, thus a dual AGN candidate. In this work, new optical long-slit spectroscopic observations clearly show that this object is rather a triple peaked narrow emission line galaxy, with both blue and red shifted narrow emission lines, as well as a much narrower emission line centred at the host galaxy systemic velocity. The average velocity offset between the blue and red shifted components is ∼500 km s−1, which is producing the apparent double-peaked emission lines. These two components are in the loci of AGN in the Baldwin, Phillips & Terlevich diagrams and are found to be spatially separated by ∼76 pc. Analysis of the optical spatially resolved spectroscopic observations presented in this work favours that Mrk 622 is a system consisting of a composite AGN amidst a binary AGN candidate, likely the result of a recent merger. This notwithstanding, outflows from a starburst, or single AGN could also explain the triple nature of the emission lines.
The stellar mass, star formation rate and dark matter halo properties of LAEs at z ∼ 2
Authors: Kusakabe Haruka , Shimasaku Kazuhiro , Ouchi Masami , Nakajima Kimihiko , Goto Ryosuke , Hashimoto Takuya , Konno Akira , Harikane Yuichi , Silverman John D , Capak Peter L 
Published: November 2017

Abstract
We present average stellar population properties and dark matter halo masses of z ∼ 2 Lyα emitters (LAEs) from spectral energy distribution fitting and clustering analysis, respectively, using ≃ 1250 objects ($\mathit {NB387}\le 25.5$) in four separate fields of ≃ 1 deg2 in total. With an average stellar mass of 10.2 ± 1.8 × 108 M⊙ and star formation rate of 3.4 ± 0.4 M⊙ yr−1, the LAEs lie on an extrapolation of the star-formation main sequence (MS) to low stellar mass. Their effective dark matter halo mass is estimated to be $4.0_{-2.9}^{+5.1} \times 10^{10}{\,\,}M_{\odot }$ with an effective bias of $1.22^{+0.16}_{-0.18}$, which is lower than that of z ∼ 2 LAEs (1.8 ± 0.3) obtained by a previous study based on a three times smaller survey area, with a probability of 96%. However, the difference in the bias values can be explained if cosmic variance is taken into account. If such a low halo mass implies a low H i gas mass, this result appears to be consistent with the observations of a high Lyα escape fraction. With the low halo masses and ongoing star formation, our LAEs have a relatively high stellar-to-halo mass ratio (SHMR) and a high efficiency of converting baryons into stars. The extended Press–Schechter formalism predicts that at z = 0 our LAEs are typically embedded in halos with masses similar to that of the Large Magellanic Cloud (LMC); they will also have similar SHMRs to the LMC, if their star formation rates are largely suppressed after z ∼ 2 as some previous studies have reported for the LMC itself.
The winning personality
Authors: Zhao Li , Jung Ha-Brookshire 
Published: November 2017

PurposeGrounded in Barney’s (1991) resource-based view of the firm and social network theory, and utilizing the Big Five factors as outlined by McCrae and Costa (1997), the purpose of this paper is to investigate how founders’ personality traits impact the quality of a firm’s network relationships, its competitive advantages, and the performance of Chinese apparel new ventures.Design/methodology/approachAn online survey was conducted, employing a purposive sampling technique. Founders or members of a founding team currently operating a business in the apparel industry in China who have been in business for five years or less were chosen for this study. The survey yielded 210 usable responses, which were used for further data analysis. Confirmatory factor analysis was first conducted to find a better model for the measurement of each latent variable. Structural equation modeling in AMOS 24 was then used to test the study’s hypothesized model.FindingsThe most notable finding was that three of the personality traits studied – openness to experience, agreeableness, and emotional stability – had statistically significant influences on the quality of firms’ relationships with supply-chain partners, but for the traits of extraversion and conscientiousness no influence was found. Further, perceived quality of firms’ network relationships helped enhance competitive advantages and firm performance. The findings identified unique personality traits that founders must possess for successful network relationships and are critical for the performance of Chinese apparel new ventures.Originality/valueThis is one of a few studies that simultaneously evaluate the impact of the personality traits of founders and the network resources of firms on the performance of new ventures in China. Its findings may help those who are interested in starting new ventures in the Chinese apparel industry to manage the external network relationships that are critical for new venture success. Supply-chain partners could also utilize these findings to create appropriate strategies for improving relationships with Chinese apparel new ventures to cope with the critical business challenges of globalization and collaboration.