bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Social Movements and the Governance of the Firm: Past, Present, and Future
Authors: Clark Cynthia E. , Arora Punit , Gabaldón Patricia , Jain Tanusree 
Published: October 2024

ABSTRACTResearch Question/IssueThe objective of this special issue (SI) is to galvanize research that examines the impact of different kinds of global social movements (GSMs) on the practice of international corporate governance.Research Findings/InsightsThe articles included in this SI provide unique insights into how various GSMs, including the feminist, #blacklivesmatter, and climate movements, influence and are influenced by corporate governance actors and practices across different institutional contexts.Theoretical/Academic ImplicationsExecutives and boards face increasing pressures to make corporate decisions that consider the demands emerging from different GSMs. This SI uncovers how and why some social movements weigh heavier in corporate decision‐making. This SI uncovers the implications of GSMs for corporate governance actors and processes in different institutional contexts.Practitioner/Policy ImplicationsEquipped with the power of the internet, recent social movements have become more global in character. The rising power, reach, and prominence of large corporations have made them a common target of GSMs that aim to influence not only societal values but also corporate values. The articles in this SI provide useful insights into how GSMs engage with corporations and corporate actors and assess their impact on the governance of the firm in different countries.
Sodium‐glucose co‐transporter 2 inhibitors for all‐cause and cardiovascular death in people with different stages of CKD: A systematic review and meta‐analysis
Authors: Karagiannidis Artemios G. , Theodorakopoulou Marieta P. , Alexandrou Maria‐Eleni , Iatridi Fotini , Karkamani Eleni , Anastasiou Vasileios , Mykoniatis Ioannis , Kamperidis Vasileios , Strippoli Giovanni , Sarafidis Pantelis 
Published: October 2024

AbstractBackgroundSodium‐glucose co‐transporter‐2 inhibitors (SGLT2is) reduce cardiovascular risk in people with diabetes and established cardiovascular disease, but emerging studies in chronic kidney disease (CKD) have inconsistent results. In this systematic review, we evaluate the effects of SGLT2is on cardiovascular mortality in people with CKD as a whole and across subgroups stratified by baseline kidney function and among people at low, moderate, high and very high risk according to KDIGO‐ CKD classification system.MethodsLiterature search was conducted in PubMed/MEDLINE, Cochrane/CENTRAL, Scopus and Web of Science up to 30 November 2023. We included randomized controlled trials assessing the effect of SGLT2is on cardiovascular mortality in people with CKD. Secondary outcomes included all‐cause mortality and major adverse cardiac events (MACE).ResultsEleven studies (n = 83,203 participants) were included. In people with CKD, treatment with SGLT2is compared to placebo reduced the risk of cardiovascular death by 14% (hazard ratio [HR] .86; 95%CI .79–.94), all‐cause death by 15% (HR .85; 95%CI .79–.91) and MACEs by 13% (HR .87; 95%CI .81–.93). A consistent treatment effect was observed across eGFR‐subgroups (≥60 mL/min/1.73 m2: HR .82, 95%CI .65–1.02; <60 mL/min/1.73 m2: HR .86, 95%CI .77–.96, p‐subgroup difference = .68) and KDIGO risk‐categories (low, moderate, high and very high) (p‐subgroup difference = .69) for cardiovascular death; reduction in the risk of all‐cause death tended to be greater in the highest KDIGO risk categories. A consistent treatment effect on cardiovascular mortality was observed for different SGLT2is agents studied. Sensitivity analysis for cardiovascular mortality endpoint including studies in diabetic people yielded similar results (HR .86; 95%CI .77–.97).ConclusionsTreatment with SGLT2is led to a significant reduction in the risk of cardiovascular and all‐cause mortality in people with different CKD stages. These findings support the use of SGLT2is as an adjunct cardiovascular protective therapy in CKD.PROSPERO Registration NumberPROSPERO registration number: CRD42022382863.
Impact of TP53 Mutation Status in Elderly AML Patients When Adding All‐Trans Retinoic Acid or Valproic Acid to Decitabine
Authors: Bresser Helena , Schmoor Claudia , Grishina Olga , Pfeifer Dietmar , Thomas Johanna , Rehman Usama‐Ur , Crysandt Martina , Jost Edgar , Thol Felicitas , Heuser Michael , Götze Katharina S. , Schlenk Richard F. , Salih Helmut R. , Schittenhelm Marcus M. , Heil Gerhard , Schwaenen Carsten , Müller‐Tidow Carsten , Brugger Wolfram , Kündgen Andrea , de Wit Maike , Giagounidis Aristoteles , Scholl Sebastian , Neubauer Andreas , Krauter Jürgen , Bug Gesine , May Annette M. , Wäsch Ralph , Duyster Justus , Döhner Konstanze , Ganser Arnold , Döhner Hartmut , Hackanson Björn , Becker Heiko , Lübbert Michael 
Published: October 2024

ABSTRACTIn a randomized phase II trial (AMLSG 14‐09, NCT00867672) of elderly, newly diagnosed AML patients, ATRA combined with decitabine (DEC) significantly improved the overall response rate (ORR) and survival also in patients with adverse‐risk genetics, without adding toxicity. We performed a post hoc analysis to determine the predictive impact of TP53 status. Despite a nominally higher ORR, the clinically meaningful survival benefit when adding ATRA to DEC was diminished, but not completely negated, in TP53‐mutated patients. Indeed, 2 out of 14 TP53‐mutated patients (14%) randomized to a DEC + ATRA‐containing regimen lived for > 36 months. Further studies of ATRA combined with hypomethylating agents appear warranted in non‐M3 AML patients ineligible for HMA/venetoclax therapy.
Trial Registration: ClinicalTrials.gov identifier: NCT00867672
Strengthening the Skin Barrier by Using a Late Cornified Envelope 6A‐Derived Biomimetic Peptide
Authors: Pancarte Mikaël , Leignadier Julie , Courrech Séverine , Serre Guy , Attia Joan , Jonca Nathalie 
Published: October 2024

ABSTRACTChanges in the expression of cornified envelope (CE) components are a hallmark of numerous pathological skin conditions and aging, underlying the importance of this stratum corneum structure in the homeostasis of the epidermal barrier. We performed a detailed characterisation of LCE6A, a member of the Late Cornified Envelope protein family. Immunohistochemical and immunoblot experiments confirmed that LCE6A is expressed late during epidermal differentiation. Crosslinking assays of recombinant LCE6A performed either in situ on human skin sections or in vitro demonstrated that LCE6A is indeed a substrate of transglutaminases and crosslinked to CEs. LCE6A‐derived peptides containing a glutamine‐lysine sequence retained these properties of the full‐length protein and reinforced the mechanical resistance of CE submitted to sonication. We designed P26, a LCE6A‐derived biomimetic peptide that similarly reinforced CE in vitro, and evaluated its protective properties ex vivo, on human skin explants, and in two double blind and vehicle‐controlled clinical trials. P26 was able to protect the skin from barrier disruption, to limit the damage resulting from a defective barrier, and could improve the signs of aging such as loss of skin firmness and increased skin roughness. Hence, our detailed characterisation of LCE6A as a component of the CE enabled us to develop a LCE6A‐derived peptide, biologically active with a new and original mode of action that could be of great interest as a cosmetic ingredient and a pharmacologic agent.
Projects with no cost of capital
Authors: Levy Moshe 
Published: October 2024

AbstractIt is generally accepted that any project has an appropriate cost of capital reflecting its riskiness and that this cost of capital can be employed to calculate the project's net present value (NPV). Consequently, any future cashflow with a positive expected value has some positive present value. We show that this is not generally true. A risky cashflow with a positive expected value may have a negative present value if the cashflow is correlated with market returns. Thus, there are many realistic projects for which no cost of capital exists. We suggest a simple test to screen out such projects.
Comparing the effectiveness of a blended video plus face‐to‐face educational program with a face‐to‐face educational program on quality of life among adolescents undergoing hemodialysis in Palestine
Authors: Fashafsheh Nawras , Chui Ping Lei , Danaee Mahmoud , Ayed Ahmad , Lai Lee Lee 
Published: October 2024

AbstractIntroductionHemodialysis is frequently used as a primary treatment for individuals with end‐stage kidney disease (ESKD), and it significantly impacts the quality of life in adolescents undergoing this procedure. Providing a hemodialysis education to these patients is a valuable strategy for enhancing their well‐being. The aim of the study is to assess the effect of the video‐assisted educational program on the quality of life among adolescents undergoing hemodialysis in Palestine.MethodsThis study employed a quasi‐experimental design, a pre‐test–post‐test interventional study, involving a sample of 68 adolescent patients between the ages of 13 and 18 diagnosed with ESKD. The quality of life level was assessed in both groups using an Arabic version of the Pediatric Quality of Life Inventory™ version 3.0 ESKD Module survey. The study was conducted at the dialysis units in four hospitals associated with Augusta Victoria Hospital, An‐Najah University Hospital, Palestine Medical Complex/Ramallah, and Beit Jala (Al Housain) Hospital. The study involved providing tailored face‐to‐face educational sessions with video assistance to the experimental group, while the control group received regular face‐to‐face education.FindingsThe Generalized Estimating Equation analysis revealed no significant differences in quality of life between the experimental and control groups over time, across pre‐test, post‐test, and follow‐up periods (p ≥ 0.05). However, within the experimental group, there was a significant improvement in total quality of life scores between the pre‐test, post‐test, and post‐test follow‐up (p ≤ 0.001), although the difference between the pre‐test and follow‐up approached significance but was not statistically significant (p = 0.056). In contrast, the control group showed significant differences in quality of life across the pre‐test, post‐test, and follow‐up time points (p ≤ 0.05).DiscussionImplementing suitable interventions can potentially enhance the quality of life for individuals undergoing hemodialysis. Consequently, we suggest using video‐based education as a cost‐effective, uncomplicated, and engaging approach for educating hemodialysis patients.
Preserved working memory performance along with subcortical modulation during peri‐ictal phases in spontaneous migraine attacks
Authors: Ruiz‐Tagle Amparo , Caetano Gina , Fouto Ana , Esteves Inês , Cabaço Inês , Da Silva Nuno , Vilela Pedro , Alves Pedro Nascimento , Martins Isabel Pavão , Gouveia Raquel Gil , Figueiredo Patrícia 
Published: October 2024

AbstractObjectiveTo analyze cognitive performance and brain activation during a working memory task in patients with migraine during various phases of the migraine cycle and compare to healthy participants.BackgroundCognitive difficulties reported during migraine attacks remain poorly understood, despite evidence that the lateral frontoparietal network undergoes reversible disturbances and decreased activation during attacks. Recent findings in resting state functional magnetic resonance imaging suggest that brain areas involved in this network interact with subcortical regions during spontaneous migraine attacks.MethodsIn this prospective, within‐subject study, 10 patients with diagnosed menstrual‐related episodic migraine without aura underwent 3T functional magnetic resonance imaging assessments while performing a working memory task across four phases of the natural migraine cycle: peri‐ictal (preictal, ictal, postictal) phases and interictally (between attacks). Migraine prophylaxis was an exclusion criterion. Fourteen healthy controls were assessed during the corresponding phases of their menstrual cycles.ResultsThe protocol was completed by 24 female participants aged 21 to 47 years: 10 with migraine (four sessions each) and 14 healthy controls (two sessions each) yielding a total of 68 analyzed datasets. Patients and controls showed similar performance on the working memory task and displayed increased brain activity in regions linked to this function, namely the middle frontal gyrus, inferior parietal lobe, and anterior cingulate cortex, during all phases of the migraine/menstrual cycle. Patients with migraine (N = 10) exhibited a significant decrease in hypothalamic activity (p = 0.007) as measured by the percent signal change (PSC) during the postictal phase compared to perimenstrual controls (N = 14), with −2 (16) and 31 (35) PSC, respectively. Comparing across the migraine cycle, the change in hypothalamic activity relative to controls in the postictal phase −0.33 (0.2) ΔPSC was significantly different from the ones in the interictal (0.006 [0.5] ΔPSC; p = 0.002) and preictal (−0.08 [0.4] ΔPSC; p = 0.034) phases.ConclusionDuring a working memory task, cognition‐related brain activation was present across all phases of the migraine cycle similarly to healthy control participants. Patients with migraine, however, displayed lower neural activity at the subcortical level in the postictal phase. Nonetheless, the sample size is a limitation for the generalization of our results. More research is needed to fully understand how the brain copes with cognitive demands during spontaneous migraine attacks.
“Doing reviews is an unpaid service”: Why female Chinese novice applied linguistics researchers choose to participate in the peer review process
Authors: Zeng Ting 
Published: October 2024

AbstractThis article reports on an exploratory inquiry conducted with female Chinese novice researchers in the field of applied linguistics in relation to their experiences of serving as peer reviewers. Drawing on self‐determination theory, I analyzed and interpreted the accounts of reviewing that the participants shared through semi‐structured interviews. The analysis revealed that these female Chinese novice researchers were extrinsically motivated to review peers’ work for journals. They associated doing peer reviews with beneficial outcomes, such as career advancement, public recognition, and the approval of supervisors. Their accounts are also indicative of intrinsic motivation to review peers’ work, mediated by their interactions with colleagues and supervisors. In response to these findings, the study concludes that further research should be done to identify how novice researchers can be motivated to become more involved in the peer review process and knowledge construction.
Choosing the optimal therapy for metastatic renal cell carcinoma: Insights from a real‐world comparative study
Authors: Hara Takuto , Teishima Jun , Okamura Yasuyoshi , Suzuki Kotaro , Bando Yukari , Terakawa Tomoaki , Chiba Koji , Hyodo Yoji , Miyake Hideaki 
Published: October 2024

BackgroundThe evolution of combination therapies integrating immune checkpoint inhibitors has revolutionized the first‐line treatment of metastatic renal cell carcinoma (mRCC). Although these therapies are clinically approved, direct comparisons between dual immune checkpoint inhibitors (IOIO) and immune checkpoint inhibitors combined with tyrosine kinase inhibitors (IOTKI) in clinical trials are lacking. This gap creates uncertainties in selecting the most appropriate treatment based on patient‐specific factors.MethodsThis study employed the inverse probability of treatment weighting (IPTW) method to analyze progression‐free survival (PFS) and overall survival (OS) for patients with mRCC receiving IOIO or IOTKI treatment regimens.ResultsA total of 171 patients were analyzed after applying inclusion criteria and propensity scoring. The study found no significant differences in PFS and OS between the two treatment modalities in the IPTW cohort. However, subgroup analyses revealed that IOTKI therapy was associated with better PFS and OS for patients without bone metastases and better OS for patients with a body mass index (BMI) over 25. IOIO therapy showed better OS for patients with a BMI below 18.5.ConclusionBoth IOIO and IOTKI therapies were effective. Therapy selection could be better tailored to patient characteristics by including factors such as the presence of bone metastases and BMI. This study enhances understanding of how patient‐specific factors interact with different treatment modalities, potentially guiding more personalized treatment decisions in clinical practice for mRCC.
Muscular dystrophy as a cause of unilateral scapular winging
Authors: Lycett Mitchell J. , Dalton Seamus E. , Kumar Kishore R. , Ng Karl 
Published: October 2024

AbstractShoulder weakness with unilateral scapular winging is a common issue that initially presents to the general physician, sports physician or rheumatologist. Although most of these cases are neurogenic in nature, it is important to consider alternative causes for unilateral scapular winging. Muscular dystrophies can present with marked asymmetry, the most typical being facioscapulohumeral dystrophy (FSHD). We describe a case of FSHD with a summary of the key clinical features to increase the awareness of this condition among physicians.
A comparison of procedure‐related adverse events between two right ventricular leadless pacemakers
Authors: Bahbah Ali , Sengupta Jay , Kapphahn‐Bergs Melanie , Witt Dawn , Zishiri Edwin , Sharkey Scott , Strepkos Dimitrios , Alexandrou Michaella , Abdelhadi Raed , Hauser Robert 
Published: October 2024

AbstractIntroductionThe Medtronic Micra VR and Abbott AVEIR VR are the leadless pacemakers (LPM) currently available in the United States (US). Micra VR employs fixation tines and the AVEIR VR uses an active fixation helix. Micra VR requires fixation before electrical measurements are obtained, while R‐waves may be mapped by AVEIR VR without fixation. Little comparative data is available for these LPMs. Accordingly, we compared the incidences of procedure‐related major adverse clinical events (MACE) and device problems in the US for Micra VR and AVEIR VR during 2022–2024.MethodsWe searched the FDA's Manufacturer and User Facility Device Experience (MAUDE) database for US reports of MACE and device problems that were filed from April 2022 to December 2023 for AVEIR VR, and from June 2022 to April 2024 for Micra VR. Totals for US‐registered LPM implants were obtained from the manufacturers' product performance reports.ResultsDuring the study period, 5990 AVEIR VR and 10 940 Micra VR implants were registered in the US. We found 305 MAUDE reports for AVEIR VR (5.1%), versus 541 MAUDE reports for Micra VR (4.9%) (p = .702). The incidence of MACE was 0.72% (43/5990) for AVEIR VR versus 0.59% (65/10 940) for Micra VR, (p = .387). The incidences of procedure‐related death, cardiac perforation. cardiac arrest, emergency pericardial drainage or reparative surgery were similar for both LPMs (p > .05). Micra VR had more unacceptable thresholds requiring LPM replacement compared to AVEIR VR (95;0.9% vs. 24;0.4%; p = .001). AVEIR VR had a statistically higher incidence of device dislodgement during (32) and after (21) implant compared to Micra VR (53 (0.9%) vs. 46 (0.4%), p < .001).ConclusionsMicra VR and AVEIR VR have similar procedural safety profiles, including the incidences of death and perforation. However, device problems differed significantly, possibly related to their design differences. Compared to Micra VR, AVEIR VR appears to have an advantageous threshold measurement capability but is more prone to device dislodgement.
Classification and functional analysis of disulfidptosis‐associated genes in sepsis
Authors: He Simeng , Zhang Xiangxin , Wang Zichen , Zhang Qingju , Yao Yu , Pang Jiaojiao , Chen Yuguo 
Published: October 2024

AbstractSepsis represents a critical condition characterized by multiple‐organ dysfunction resulting from inflammatory response to infection. Disulfidptosis is a newly identified type of programmed cell death that is intimately associated with the actin cytoskeleton collapse caused by glucose starvation and disulfide stress, but its role in sepsis is largely unknown. The study was to adopt a diagnostic and prognostic signature for sepsis with disulfidptosis based on the differentially expressed genes (DEGs) between sepsis and healthy people from GEO database. The disulfidptosis hub genes associated with sepsis were identified, and then developed consensus clustering and immune infiltration characteristics. Next, we evaluated disulfidptosis‐related risk genes by using LASSO and Random Forest algorithms, and constructed the diagnostic sepsis model by nomogram. Finally, immune infiltration, GSVA analysis and mRNA‐miRNA networks based on disulfidptosis‐related DEGs were screened. There are five upregulated disulfidptosis‐related genes and seven downregulated genes were filtered out. The six intersection disulfidptosis‐related genes including LRPPRC, SLC7A11, GLUT, MYH9, NUBPL and GYS1 exhibited higher predictive ability for sepsis with an accuracy of 99.7%. In addition, the expression patterns of the critical genes were validated. The study provided a comprehensive view of disulfidptosis‐based signatures to predict the prognosis, biological features and potential treatment directions for sepsis.
FANCD2 as a ferroptosis‐related target for recurrent implantation failure by integrated bioinformatics and Mendelian randomization analysis
Authors: Zhou Yuanyuan , Luo Yujia , Zeng Wenshan , Mao Luna , Le Fang , Lou Hangying , Wang Liya , Mao Yuchan , Jiang Zhou , Jin Fan 
Published: October 2024

AbstractDespite advancements in assisted reproductive technology, recurrent implantation failure (RIF) remains a challenge. Endometrial factors, including ferroptosis and immunity, may contribute to this issue. This study integrated bioinformatics analysis and Mendelian randomization (MR) to investigate the expression and significance of DEFRGs in RIF. We intersected 484 ferroptosis‐associated genes with 515 differentially expressed genes (DEGs) to identify key DEFRGs. Subsequent analyses included enrichment analysis, molecular subtype identification, machine learning model development for biomarker discovery, immune cell infiltration assessment, single‐cell RNA sequencing, and MR to explore the causal relationships of selected genes with RIF. In this study, we identified 11 differentially expressed ferroptosis‐related genes (DEFRGs) between RIF and healthy individuals. Cluster analysis revealed two distinct molecular subtypes with different immune profiles and DEFRG expressions. Machine learning models highlighted MUC1, GJA1 and FANCD2 as potential diagnostic biomarkers, with high accuracy in RIF prediction. Single‐cell analysis further revealed the cellular localization and interactions of DEFRGs. MR suggested a protective effect of FANCD2 against RIF. Validation in RIF patients confirmed the differential expression of key DEFRGs, consistent with bioinformatics findings. This comprehensive study emphasize the significant role of DEFRGs in the pathogenesis of RIF, suggesting that modulating these genes could offer new avenues for treatment. The FANCD2 is a potential gene contributing to RIF pathogenesis through a non‐classical ferroptosis‐dependent pathway, providing a foundation for personalized therapeutic strategies in RIF management.