bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of Healthy Products Using Spider Conch (Gastropoda stromboidea)
Authors: Garces, Jr. Sulpicio D. , Pepito Mario Ramil , Minoza Kevin L. , Diaz Welou Dil B. , Tejas Edison C. 
Published: November 2016

For years now, most doctors have insisted that an average diet that consists of healthy seafood at least twice a week can improve the quality of life (No, Meyers, Prinyawiwatkul, & Xu, 2007). The study utilized an experimental method in developing healthy products out of spider conch (Gastropoda stromboidea) shellfish. Spider conch extract was used in the formulation of sauce as an alternative product while the spider conch meat after the extraction was used for the development of the spread and patty. Panel responses were analyzed using 7 and 9-point hedonic scales. One Way Analysis of Variance was also used to determine whether a significant difference existed between and among the experimental lots. Findings showed that spider conch extract is good for sauce formulation, and the spider conch meat are good in preparing spread. Also, the study reveals that there is no significant difference between the variants of spider conch sauce and spread for taste; patty for aroma attributes, therefore, the null hypothesis was accepted. It was concluded that the developed spider conch sauce is a better alternative product that the commercial sauces available in the market regarding vitamins, protein, and iodine content.Â The researchers recommend the use of Cooking Manual and Procedures for HRM students.
Catchments' hedging strategy on evapotranspiration for climatic variability
Authors: Zhang Chi , Ding Wei , Li Yu , Tang Yin , Wang Dingbao 
Published: November 2016

AbstractIn this paper, we test the hypothesis that natural catchments utilize hedging strategy for evapotranspiration and water storage carryover with uncertain future precipitation. The hedging strategy for evapotranspiration in catchments under different levels of water availability is analytically derived with marginal utility principle. It is found that there exists hedging between evapotranspiration for present and future only with a portion of water availability. Observation data sets of 160 catchments in the United States covering the period from 1983 to 2003 demonstrate the existence of hedging in catchment hydrology and validate the proposed hedging strategy. We also find that more water is allocated to carryover storage for hedging against the future evapotranspiration deficit in the catchments with larger aridity indexes or with larger variability in future precipitation, i.e., long‐term climate and precipitation variability control the degree of hedging.
Adaptive kernels in approximate filtering of state‐space models
Authors: Dedecius Kamil 
Published: November 2016

SummaryStandard Bayesian algorithms used for online filtering of states of hidden Markov models from noisy measurements assume an accurate knowledge of the measurement model in the form of a conditional probability density function. However, this knowledge is often unreachable in practice, and the used models are more or less misspecified, or it is too complex, making the resulting models intractable. This paper focuses on these issues from the particle filtering perspective. It adopts the principles of the approximate Bayesian filtering, where the particle weights are based on the (dis)similarity of the true measurements and the pseudo‐measurements obtained by plugging the state particles directly into the measurement equation. Specifically, a new robust method for online tuning of the weighting kernel is proposed. Copyright © 2016 John Wiley & Sons, Ltd.
Schwefel in der modernen Materialwissenschaft
Authors: Boyd Darryl A. 
Published: November 2016

AbstractSchwefel ist eines der häufigsten Elemente im Universum, fällt als Hauptnebenprodukt bei der Erdölraffination an und stellt ein häufiges Reaktionszentrum in biologischen Systemen dar. Die Forschung über Schwefel ist daher breit gefächert und hat große Relevanz und Auswirkungen auf unser tägliches Leben. So hat das Interesse an schwefelbasierten Reaktionen in den letzten zehn Jahren eine deutliche Wiederbelebung erfahren. Weitere relevante Themengebiete sind Forschungen zur Verbesserung von Energieeffizienzen, umweltfreundliche Anwendungen für Abfallprodukte der Erdölraffination, Polymere mit besonderen optischen und mechanischen Eigenschaften sowie Materialien für biologische Anwendungen. Dieser Aufsatz stellt einige der neuesten Anwendungen von Schwefel und schwefelbasierten Reaktionen für die Herstellung von Materialien für den Energiebereich, Umweltschutz und andere praktische Anwendungen vor.
The Development of Psoriatic Arthritis in Patients With Psoriasis Is Preceded by a Period of Nonspecific Musculoskeletal Symptoms: A Prospective Cohort Study
Authors: Eder Lihi , Polachek Ari , Rosen Cheryl F. , Chandran Vinod , Cook Richard , Gladman Dafna D. 
Published: November 2016

ObjectiveTo assess whether the presence of nonspecific musculoskeletal symptoms, their degree, and change over time predict the development of psoriatic arthritis (PsA) in a prospective cohort of psoriasis patients without arthritis at baseline.MethodsThis prospective cohort study involved patients with psoriasis who were assessed at baseline to exclude the presence of clinical PsA. The study participants were reassessed annually to determine if they had developed PsA. The presence of musculoskeletal symptoms and the patients’ assessments of pain, fatigue, stiffness, physical function, and psychological distress were recorded at each visit. Cox proportional hazards models were used to assess what symptoms predicted the development of PsA.ResultsA total of 57 of 410 psoriasis patients developed PsA. At baseline, the presence of arthralgia in women (hazard ratio [HR] 2.59, P = 0.02), heel pain (HR 4.18, P = 0.02), high fatigue score (HR 2.36, P = 0.007), and high stiffness score (HR 2.03, P = 0.045) predicted subsequent development of PsA. In addition, an increase from baseline in fatigue score (HR 1.27, P = 0.001), pain score (HR 1.34, P < 0.001), and stiffness score (HR 1.21, P = 0.03), and a worsening in physical function score (HR 0.96, P = 0.04) predicted the development of PsA.ConclusionA preclinical phase exists in patients with PsA prior to the diagnosis of the disease. This phase is characterized by nonspecific musculoskeletal symptoms, including joint pain, fatigue, and stiffness.
Conjugated Oligothiophene Derivatives Based on Bithiophene with Unsaturated Bonds as Building Blocks for Solution‐Processed Bulk Heterojunction Organic Solar Cells
Authors: Cui Chaohua , Wu Yue , Cheung Man‐Sing , Ho Cheuk‐Lam , Dong Qingchen , Lin Zhenyang , Li Yongfang , Wong Wai‐Yeung 
Published: November 2016

AbstractA new building block ATVTA that uses stiff carbon–carbon triple bonds (A) on 1,2‐di(2‐thienyl)‐ethene (TVT) has been developed. Oligothiophene derivatives S‐01 with a TVT unit, S‐02 with a 5,5′‐diethynyl‐2,2′‐dithienyl (AT2) unit and S‐03 with ATVTA were synthesized to compare their effects in a systematic study. Due to the better π‐conjugation extension of the TVT unit, S‐01 exhibits the most red‐shifted absorption profile among them, whereas S‐02 possesses the deepest HOMO level. While the HOMO level of S‐03 is down‐shifted by 0.02 eV relative to that of S‐01, the alkyne linkages can effectively down‐shift the HOMO level. By replacing the terminal units of S‐03 with stronger electron acceptors, S‐04 and S‐05 exhibited broader absorption profiles and lower HOMO levels than those of S‐03. Organic solar cells based on these molecules were fabricated and an S‐03:PC60BM (1:1, w/w) based device afforded the highest Voc value of 0.96 V and a power conversion efficiency (PCE) of 2.19 %.
Exohedral Complexation of B40, C60 and Arenes with Transition Metals: A Comparative DFT Study
Authors: Karmodak Naiwrit , Jemmis Eluvathingal D. 
Published: November 2016

AbstractHoles are inevitable in borospherenes. The surface topography of B40 and its π MOs isolobal to benzene allow for better η7‐, η6‐ and η3‐ exohedral complexation with transition metal fragments than it is possible with C60 and arenes. η7‐complexes of B40 is lower in energy than the η6‐complexes for metal fragments such as C5H5Mn, C4H4Fe, and C3H3Co that have relatively diffuse frontier orbitals. The fragment C6H6Cr prefers η6‐coordination. Near‐isodesmic equations based on density functional theory computations of the transition metal complexes of B40, C60 and C6H6 support these anticipations. Transition metal complexation increases the stability of B40.
Synthesis of Thioethers and Thioesters with Alkyl Arylsulfinates as the Sulfenylation Agent under Metal‐Free Conditions
Authors: Li Yahui , Zhu Fengxiang , Wang Zechao , Wu Xiao‐Feng 
Published: November 2016

AbstractA study on the coupling of cycloalkanes with alkyl arylsulfinates has been performed. Using iodine as the catalyst, through C
−H bond activation and sulfinates reduction, a wide range of thioethers were produced in moderate to high yields. Additionally, various thiocarboxylic esters can also be produced by simply performing the reaction under CO pressure. Notably, this is the first report in which alkyl arylsulfinates were used as sulfenylation agents in a cross‐coupling transformation.
Detection of trace amounts of target DNA from massive background of nucleic acids by using the LM‐PCR‐based preamplification method
Authors: Pan Xiaoming , Wang Jing , Zhang Yanfang , Dong Ping , Li Chunchuan , Liang Xingguo 
Published: November 2016

AbstractThe sensitivity and specificity of DNA detection may decrease when the target DNA is in very low abundance. To effectively detect trace amounts of target DNA from massive background of nucleic acids, we have developed a powerful multiplex preamplification method based on ligation‐mediated PCR that can greatly enrich multiple target DNAs from massive backgrounds. By employing type IIS restriction endonuclease (REase) and specifically designed oligonucleotide adapters, target DNA can be preamplified with high efficiency and sensitivity. Combining with normal PCR, 10 copies of target DNA was effectively detected from over 108 times more excessive backgrounds with high specificity and 10 times more effectively than conventional PCR. In particular, the usage of universal primer in the preamplification PCR (pre‐amp PCR) ensured that multiple targets could be equivalently amplified, which was confirmed by quantitative PCR (qPCR), indicating it could meet the demands of high‐throughput detection. The flexibility and applicability of pre‐amp PCR was validated by using different microorganisms DNA as targets and employing two different type IIS REases. The results suggest that the pre‐amp PCR method has broad application prospects in various gene detection fields.
Ingenieurholzbau für mehrgeschossige Industriebauten – Konzept und Detaillösungen
Authors: Scheu Markus , Scheffler Jürgen , Jahreis Markus , Oppel Mike , Rautenstrauch Karl 
Published: November 2016

AbstractEin mehrgeschossiges Firmengebäude in Berlin wurde in Holz‐ und Holz‐Beton‐Verbundbauweise errichtet. Die sichtbare Konstruktion aus Brettschichtholz erstreckt sich teilweise über vier Etagen und erforderte eine Auslegung der Brandsicherheit nach R90. Entworfen wurde das Gebäude durch die Roswag Architekten, die Konzeption für die Holzkonstruktion sowie die Holz‐Beton‐Verbunddecken erfolgte durch die Stephan Holzbau GmbH. Eine besondere Herausforderung stellten die Knotenpunkte dar, bei denen die hohen Stützenlasten durch die Durchlaufträger aus Brettschichtholz hindurchzuleiten waren. Hierfür kam eine Sonderlösung mit Polymerverguss zum Einsatz. Bohrungen, quer zur Spannrichtung, wurden mit einem hochfesten Polymerverguss gefüllt, die Lasten konnten auf kleinem Raum über diese integrierten Vergusssäulen durch den Träger hindurch weitergeleitet werden. Die Querschnittsreduzierung bleibt äußerst gering und somit die Durchlaufwirkung erhalten. Bauseitig bestanden sehr hohe Anforderungen an die Maßhaltigkeit. Die geringen Bauteiltoleranzen der Sichtkon struktion waren problemlos über den CNC‐Abbund und Verguss im Werk steuerbar. Durch den Einsatz von Polymerverguss konnten die Kosten für diese Verbindung, verglichen mit einer Standardlösung mit Stahleinbauteilen, um ca. 30 % reduziert werden. Im Artikel werden Ansätze und Lösungen für die Holz‐Beton‐Verbunddecken und die Knotenpunkte vorgestellt sowie nähere Ausführungen zu deren Anwendungspotenzial auf Grundlage der Entwicklungsarbeit der Professur Holz‐ und Mauerwerksbau gegeben.
Kraftflussoptimierte Verbindungen im Ingenieurbau
Authors: Weber Jan , Kjølsrud Eirik , Schober Kay‐Uwe 
Published: November 2016

AbstractDie Herstellung von geometrisch komplexen Geometrien erfolgt mithilfe von CAD‐Lösungen, welche über entsprechende Schnittstellen direkt an CAM‐Prozesse gekoppelt sind. Dabei werden verschiedene Verfahren zur Geometrieerzeugung von Knotenverbindungen verwendet, welche im Bericht vorgestellt sind. Die aufwändigste Variante besteht in der Produktion eines Urmodells, welches durch anschließendes Abformen und Ausgießen des Negativs mit einem leistungsfähigen Vergussmaterial der konventionellen Stahlgusstechnik nahekommt. Weitere Verfahren basieren auf der Laserschneidtechnik, bei der die jeweiligen Knotengeometrien zunächst aus ebenen Plattenmaterialien erzeugt werden und nach einem Faltprozess als Schalung zur Verfügung stehen. Ein drittes Verfahren besteht in der Herstellung eines Hohlkörpers, der im 3‐D‐Drucker hergestellt wird und als verlorene Schalung dient. Alle Schalungen werden anschließend mit einem leistungsfähigen Vergussmaterial (Polymerbeton, ggf. UHPC) befüllt. Anzuschließende Querschnitte (Stahl, Holz, Beton, UHPC) und Einbauteile können beanspruchungsabhängig ausgeführt und verbunden werden. Eine Berechnung der Knoten kann mit den im Ingenieurbau vorhandenen numerischen Methoden (z. B. FEM‐Systeme wie ANSYS, ABAQUS) erfolgen, wobei die Materialkennwerte der jeweiligen Vergussmaterialien zugrunde gelegt werden. Die Hochschulen Trier und Mainz entwickeln gemeinsam Verfahren zur Formgenerierung, Produktion und numerischen Modellierung, welche im Aufsatz vorgestellt werden.
Role of staging laparoscopy in the stratification of patients with perihilar cholangiocarcinoma
Authors: Bird N , Elmasry M , Jones R , Elniel M , Kelly M , Palmer D , Fenwick S , Poston G , Malik H 
Published: November 2016

Abstract

Background
Cholangiocarcinoma is a rare cancer with a poor prognosis. Radical surgical resection is the only option for curative treatment. Optimal determination of resectability is required so that patients can be stratified into operative or chemotherapeutic treatment cohorts in an accurate and time-efficient manner. Staging laparoscopy is utilized to determine the presence of radiologically occult disease that would preclude further surgical treatment. The aim of this study was to analyse the utility of staging laparoscopy in a contemporary cohort of patients with perihilar cholangiocarcinoma.

Methods
Patients diagnosed with potentially resectable perihilar cholangiocarcinoma between January 2010 and April 2015 were analysed retrospectively from a prospective database linked to UK Hospital Episode Statistics data. Patients with distal cholangiocarcinoma and gallbladder cancer were excluded from analysis.

Results
A total of 431 patients with perihilar cholangiocarcinoma were referred for assessment of potential resection at a supraregional referral centre. Some 116 patients with potentially resectable disease subsequently underwent surgical assessment. The cohort demonstrated an all-cause yield of staging laparoscopy for unresectable disease of 27·2 per cent (31 of 114). The sensitivity for detection of peritoneal disease was 71 per cent (15 of 21; P &lt; 0·001). The accuracy for all-cause non-resection for staging laparoscopy was 66 per cent (31 of 47) with a positive predictive value of progress to resection of 81 per cent (69 of 85). Neither the Bismuth–Corlette nor the Memorial Sloan Kettering Cancer Center preoperative scoring system was contingent with cause of unresectability at staging laparoscopy (P = 0·462 and P = 0·280 respectively).

Conclusion
In the present cohort, staging laparoscopy proved useful in determining the presence of radiologically occult metastatic disease in perihilar cholangiocarcinoma.
Effect of bafilomycin and NAADP on membrane‐associated ATPases and respiration of isolated mitochondria of the murine Nemeth‐Kellner lymphoma
Authors: Hreniukh V. , Bychkova S. , Kulachkovsky O. , Babsky A. 
Published: November 2016

The goal of the study was to estimate the effect of a selective V‐type H+‐ATPase inhibitor bafilomycin A1 and nicotinic acid adenine dinucleotide phosphate (NAADP) on energetic processes in NK/Ly cell by directly measuring the respiration of isolated mitochondria and ATPase activities.NAADP (7 μM) increased the activity of Na+/K+‐ATPase in the postmitochondrial fraction of NK/Ly cells, but lower concentration of NAADP decreased it (0.1 and 1 μM). The increase the activity of plasma membrane Ca2+ ATPase (PMCA) under NAADP application (1 and 7 μM) was observed. However, NAADP (1 μM) decreased activities of sarcoendoplasmic reticulum Ca2+‐ATPase (SERCA) and basal Mg2+‐ATPase. Bafilomycin A1 (1 μM) increased the activity of Na+/K+‐ATPase and potentiated the effect of NAADP (1 μM) on this pump. At the same time, bafilomycin A1 (1 μM) completely prevented all effects of NAADP (1 μM) on activities of PMCA, SERCA, and basal Mg2+‐ATPase, confirming that these effects are dependent on acidic stores.Bafilomycin A1 or NAADP decreased respiratory and oxidative phosphorylation rates in NK/Ly mitochondria when α‐ketoglutarate was used as substrate in contrast to succinate. Thus, α‐ketoglutarate oxidation is more sensitive to bafilomycin A1 and NAADP influences compared with succinate oxidation. However, bafilomycin A1 + NAADP and any of these compounds separately lead to full uncoupling of mitochondria after ADP addition irrespectively to substrate used. Bafilomycin A1 affects isolated tumor mitochondria more effectively in combination with NAADP. Bafilomycin and NAADP alter some membrane‐associated ATPases and inhibit respiration in mitochondria of the Nemeth‐Kellner lymphoma.Significance of research paragraphBafilomycin A1 potentiates the effect of NAADP by inhibiting the mitochondrial energetic process in lymphoma cells and activity of Na+/K+‐ATPase. The obtained data show promising possibility to use bafilomycin A1 and NAADP as chemotherapeutic agents for lymphoma cells treatment. This is important because lymphomas are seventh most common form of cancer. Today the lymphoma mortality is 15% to 30%, whereas the effectiveness of malignant neoplasms treatment is less than 50%.
Comparison of the Catalytic Performance and Carbon Monoxide Sensing Behavior of Pd‐SnO2 Core@Shell Nanocomposites
Authors: Ogel Elen , Müller Sabrina A. , Sackmann André , Gyger Fabian , Bockstaller Pascal , Brose Eugen , Casapu Maria , Schöttner Ludger , Gerthsen Dagmar , Feldmann Claus , Grunwaldt Jan‐Dierk 
Published: November 2016

AbstractThe catalytic activity of Pd‐SnO2 core@shell nanocomposites in the oxidation of CO and their CO‐sensing behavior were compared. For this purpose, Pd particles were placed on the inside and the outside of SnO2 hollow spheres, as demonstrated by electron tomography, X‐ray photoelectron spectroscopy, and X‐ray absorption spectroscopy. Both the sensing and catalytic effect were studied in a systematic manner on such nanocomposites, and striking differences in the catalytic performance of the nanocomposites in CO oxidation and CO and H2 sensing were found. At low temperatures, SnO2@Pd was found to be a good sensor, and the light‐off temperature was significantly lower than that of Pd@SnO2. Above the ignition temperature, CO was probably rapidly removed from the gas so that the sensing effect disappeared. This demonstrated that understanding of the sensing and catalytic behavior can help in unraveling the functional properties of core@shell and Pd‐SnO2 nanocomposites in more detail.
Enhanced Activity and Recyclability of Palladium Complexes in the Catalytic Synthesis of Sodium Acrylate from Carbon Dioxide and Ethylene
Authors: Manzini Simone , Cadu Alban , Schmidt Anna‐Corina , Huguet Núria , Trapp Oliver , Paciello Rocco , Schaub Thomas 
Published: November 2016

AbstractThe Pd‐catalysed synthesis of sodium acrylate from ethylene and CO2 in the presence of alcoholate bases has been improved significantly. We used amide solvents such as N‐cyclohexylpyrrolidone or N,N‐dibutylformamide to achieve turnover numbers greater than 500 in one run, which is significantly higher than that of systems for this reaction reported previously. For the first time, we were able to recycle the catalyst without any additional regeneration step. With this system, it is possible to use the simple and easily recycled alcoholate base sodium isopropoxide to achieve good turnover numbers up to 200.
Cadmium–BINOL Metal–Organic Framework for the Separation of Alcohol Isomers
Authors: Bueno‐Perez Rocio , Merkling Patrick J. , Gómez‐Álvarez Paula , Calero Sofia 
Published: November 2016

AbstractThe large‐scale isolation of specific isomers of amyl alcohols for applications in the chemical, pharmaceutical, and biochemical industries represents a challenging task due to the physicochemical similarities of these structural isomers. The homochiral metal–organic framework cadmium–BINOL (BINOL=1,1′‐bi‐2‐naphthol) is suitable for the separation of pentanol isomers, combining adsorption selectivities above 5 with adsorption capacities of around 4.5 mol kg−1. Additionally, a slight ability for separation of racemic mixtures of 2‐pentanol is also detected. This behavior is explained based on matching shapes, strength of host–guest interactions, and on the network of hydrogen bonds. The last of these explains both the relative success and shortfalls of prediction methods at high loadings (ideal adsorbed solution theory) or at low coverage (separation factors), which are therefore useful here at a qualitative level, but not accurate in quantitative terms. Finally, the high selectivity of cadmium–BINOL for 1‐pentanol over its isomers offers prospects for practical applications and some room for optimizing conditions.
Derivation of Telencephalic Oligodendrocyte Progenitors from Human Pluripotent Stem Cells
Authors: Major Tamara , Powers Ann , Tabar Viviane 
Published: November 2016

AbstractOligodendrocytes are the main myelinating cell of the adult CNS and are vulnerable to injury in diverse disorders, such as spinal cord injury, stroke, trauma, pharmacological and radiation toxicity, as well as neuroinflammation. Human pluripotent stem cells are attractive sources of oligodendrocyte lineage cells and provide a promising treatment strategy for exogenous myelin repair through transplantation. This unit describes a protocol for the step‐wise differentiation of forebrain late oligodendrocyte progenitor cells (OPCs) from human pluripotent stem cells in defined chemical in vitro culture conditions. It involves a stepwise progression of oligodendrocyte progenitors through their known developmental phases, starting with the expression of appropriate transcription factors (Olig2, Nkx2.2), the upregulation of PDGFRA, followed by the appearance of O4‐expressing cells, then O1 expression and finally mature myelin‐binding protein (MBP) expressing cells. Validation of cell fate is performed by extensive transcriptomal profiling, as well in vitro myelination essays with hESCs‐derived neuronal cells. Recapitulating forebrain oligodendrocyte development may generate cells more suitable for transplantation strategies for disorders primarily involving the telencephalon. © 2016 by John Wiley & Sons, Inc.