bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complete anatomic reduction and monosegmental fusion for lumbar spondylolisthesis of Grade II and higher: use of the minimally invasive “rocking” technique
Authors: Rajakumar Deshpande V. , Hari Akshay , Krishna Murali , Sharma Ankit , Reddy Manjunatha 
Published: August 2017

OBJECTIVEDifferent surgical approaches have been described for treatment of spondylolisthesis, including in situ fusions, reductions of various degrees, and inclusion of healthy adjacent segments into the fusion construct. To the authors’ knowledge, there are only sparse reports describing consistent complete reduction and monosegmental transforaminal lumbar interbody fusion for spondylolisthesis using a minimally invasive technique. The authors assess the efficacy of this technique in the reduction of local deformity and correction of overall sagittal profile in single-level spondylolisthesis.METHODSThis cohort study consists of a total of 36 consecutive patients treated over a period of 6 years. Patients with varying grades of lumbar spondylolisthesis (29 Meyerding Grade II and 7 Meyerding Grade III) were treated with operative reduction via minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in which the “rocking” technique was used. The clinical outcomes were measured using the visual analog scale (VAS) for pain and the Revised Oswestry Disability Index (ODI) for low-back pain/dysfunction. Meyerding grade, pelvic incidence (PI), lumbar lordosis (LL), disc space angle (DSA), pelvic tilt (PT), and sacral slope (SS) were assessed to measure the radiological outcomes. These were reviewed for each patient for a minimum of 2 years.RESULTSAt most recent follow-up, 94% of patients were pain free. There were 2 patients (6%) who had moderate pain (which corresponded to higher-grade of listhesis), but all showed an improvement in pain scores (p < 0.05). The mean VAS score improved from 6.5 (SD 1.5) preoperatively to 1.6 (SD 1.3) and the mean ODI score improved from 53.7 (SD 13.1) preoperatively to 22.5 (SD 15.5) at 2-year follow-up.All radiological parameters improved following surgery. Most significant improvement was noted for LL, DSA, and SS. Both LL and SS were found to decrease, while DSA increased postoperatively. PI remained relatively unchanged, while PT showed a mild increase, which was not significant. Good fusion was achieved with implants in situ at 2-year follow-up. A 100% complete reduction of all grades of spondylolisthesis was achieved. The overall sagittal profile improved dramatically. No major perioperative complications were encountered.CONCLUSIONSMinimally invasive monosegmental TLIF for spondylolisthesis reduction using this rocking technique is effective in the treatment of various grades of spondylolisthesis. Consistent complete reduction of the slippage as well as excellent correction of overall sagittal profile can be achieved, and the need for including healthy adjacent segments in the fusion construct can be avoided.
Tubular microdiscectomy: techniques, complication avoidance, and review of the literature
Authors: Clark Aaron J. , Safaee Michael M. , Khan Nickalus R. , Brown Matthew T. , Foley Kevin T. 
Published: August 2017

OBJECTIVEMicroendoscopic discectomy is a minimally invasive surgery technique that was initially described in 1997. It allows surgeons to work with 2 hands through a small-diameter, operating table–mounted tubular retractor, and to apply standard microsurgical techniques in which a small skin incision and minimal muscle dissection are used. Whether the surgeon chooses to use an endoscope or a microscope for visualization, the technique uses the same type of retractor and is thus called tubular microdiscectomy. The goal in this study was to review the current literature, examine the level of evidence supporting tubular microdiscectomy, and describe surgical techniques for complication avoidance.METHODSThe authors performed a systematic PubMed review using the terms “microdiscectomy trial,” “tubular and open microdiscectomy,” “microendoscopic open discectomy,” and “minimally invasive open microdiscectomy OR microdiskectomy.” Of 317 references, 10 manuscripts were included for analysis based on study design, relevance, and appropriate comparison of open to tubular discectomy.RESULTSSimilar and very favorable clinical outcomes can be expected from tubular and standard microdiscectomy. Studies have demonstrated equivalent operating times for both procedures, with lower blood loss and shorter hospital stays associated with tubular microdiscectomy. Furthermore, postoperative analgesic usage has been shown to be significantly lower after tubular microdiscectomy. Overall rates of complications are no different for tubular and standard microdiscectomy.CONCLUSIONSProspective randomized trials have been used to evaluate outcomes of common minimally invasive lumbar spine procedures. For lumbar discectomy, Level I evidence supports equivalently good outcomes for tubular microdiscectomy compared with standard microdiscectomy. Likewise, Level I data indicate similar safety profiles and may indicate lower blood loss for tubular microdiscectomy. Future studies should examine the comparative value of these procedures.
Obesity and adverse breast cancer risk and outcome: Mechanistic insights and strategies for intervention
Authors: Picon‐Ruiz Manuel , Morata‐Tarifa Cynthia , Valle‐Goffin Janeiro J. , Friedman Eitan R. , Slingerland Joyce M. 
Published: August 2017

AbstractAnswer questions and earn CME/CNERecent decades have seen an unprecedented rise in obesity, and the health impact thereof is increasingly evident. In 2014, worldwide, more than 1.9 billion adults were overweight (body mass index [BMI], 25‐29.9 kg/m2), and of these, over 600 million were obese (BMI ≥30 kg/m2). Although the association between obesity and the risk of diabetes and coronary artery disease is widely known, the impact of obesity on cancer incidence, morbidity, and mortality is not fully appreciated. Obesity is associated both with a higher risk of developing breast cancer, particularly in postmenopausal women, and with worse disease outcome for women of all ages. The first part of this review summarizes the relationships between obesity and breast cancer development and outcomes in premenopausal and postmenopausal women and in those with hormone receptor‐positive and ‐negative disease. The second part of this review addresses hypothesized molecular mechanistic insights that may underlie the effects of obesity to increase local and circulating proinflammatory cytokines, promote tumor angiogenesis and stimulate the most malignant cancer stem cell population to drive cancer growth, invasion, and metastasis. Finally, a review of observational studies demonstrates that increased physical activity is associated with lower breast cancer risk and better outcomes. The effects of recent lifestyle interventions to decrease sex steroids, insulin/insulin‐like growth factor‐1 pathway activation, and inflammatory biomarkers associated with worse breast cancer outcomes in obesity also are discussed. Although many observational studies indicate that exercise with weight loss is associated with improved breast cancer outcome, further prospective studies are needed to determine whether weight reduction will lead to improved patient outcomes. It is hoped that several ongoing lifestyle intervention trials, which are reviewed herein, will support the systematic incorporation of weight loss intervention strategies into care for patients with breast cancer. CA Cancer J Clin 2017;67:378–397. © 2017 The Authors. CA A Cancer Journal for Clinicians published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Biomechanical comparison of pin and nitinol bone staple fixation to pin and tension band wire fixation for the stabilization of canine olecranon osteotomies
Authors: Christou Chris , Bailey Craig , Tan Chris , Culvenor John , Wang Tian , Walsh William , Lai Alen 
Published: August 2017

SummaryObjective: To compare the initial biomechanical properties of olecranon osteotomies stabilized with intramedullary pins and a Nitinol bone staple to osteotomies stabilized with pin and tension band wire fixation.Study design: Ex vivo mechanical evaluation on cadaveric bones.Material and methods: Ten pairs of cadaveric forelimbs from skeletally mature Greyhounds with an olecranon osteotomy stabilized with either a pin and Nitinol bone staple or a pin and tension band wire. A single load to failure was applied to each specimen through the triceps tendon. Biomechanical properties were compared based on stiffness, yield load, and maximum load to failure and load at 2 mm of axial displacement.Results: Specimens stabilized with the bone staple were biomechanically superior in all the variables tested. There was significantly greater stiffness (118.0 ± 25.9 N/mm versus 70.1 ± 40.4 N/mm; p = 0.005), yield load (319.0 ± 99.8 N versus 238.0 ± 42.5 N; p = 0.03), maximum load sustained (385.0 ± 99.2 N versus 287.0 ± 37.4 N; p = 0.009), and load at 2 mm of axial displacement (218.0 ± 51.5 N versus 138.0 ± 48.7 N; p = 0.002) in specimens stabilized with pins and a Nitinol bone staple than specimens stabilized with pin and tension band wire fixation.Clinical significance: The pin and Nitinol bone staple construct provides a biomechanically superior alternative to pin and tension band wire fixation for stabilization of olecranon osteotomies, and its use warrants further clinical investigation.Supplementary material for this article is available at https://doi.org/10.3415/VCOT-17-02-0025
Apparent Trend of the Iron Abundance in NGC 3201: The Same Outcome with Different Data
Authors: Kravtsov Valery V. 
Published: August 2017

Abstract
We further study the unusual trend we found at statistically significant levels in some globular clusters, including NGC 3201: a decreasing iron abundance in red giants toward the cluster centers. We first show that recently published new estimates of iron abundance in the cluster reproduce this trend, in spite of the authors’ statement about no metallicity spread due to a low scatter achieved in the [Fe ii/H] ratio. The mean of [Fe ii/H] within

from the cluster center is lower, by Δ[Fe ii/H] = 0.05 ± 0.02 dex, than in the outer region, in agreement with our original estimate for a much larger sample size within

. We found that an older data set traces the trend to a much larger radial distance, comparable with the cluster tidal radius, at Δ[Fe/H] ∼ 0.2 dex, due to higher metallicity of distant stars. We conclude the trend is reproduced by independent data sets and find that it is accompanied by both a notable same-sign trend of oxygen abundance that can vary by up to Δ[O/Fe] ∼ 0.3 dex within

and an opposite-sign trend of sodium abundance.
Detecting Proxima b’s Atmosphere with JWST Targeting CO2 at 15 μm Using a High-pass Spectral Filtering Technique
Authors: Snellen I. A. G. , Désert J.-M. , Waters L. B. F. M. , Robinson T. , Meadows V. , van Dishoeck E. F. , Brandl B. R. , Henning T. , Bouwman J. , Lahuis F. , Min M. , Lovis C. , Dominik C. , Van Eylen V. , Sing D. , Anglada-Escudé G. , Birkby J. L. , Brogi M. 
Published: August 2017

Abstract
Exoplanet Proxima b will be an important laboratory for the search for extraterrestrial life for the decades ahead. Here, we discuss the prospects of detecting carbon dioxide at 15 μm using a spectral filtering technique with the Medium Resolution Spectrograph (MRS) mode of the Mid-Infrared Instrument (MIRI) on the James Webb Space Telescope (JWST). At superior conjunction, the planet is expected to show a contrast of up to 100 ppm with respect to the star. At a spectral resolving power of R = 1790–2640, about 100 spectral CO2 features are visible within the 13.2–15.8 μm (3B) band, which can be combined to boost the planet atmospheric signal by a factor of 3–4, depending on the atmospheric temperature structure and CO2 abundance. If atmospheric conditions are favorable (assuming an Earth-like atmosphere), with this new application to the cross-correlation technique, carbon dioxide can be detected within a few days of JWST observations. However, this can only be achieved if both the instrumental spectral response and the stellar spectrum can be determined to a relative precision of ≤1 × 10−4 between adjacent spectral channels. Absolute flux calibration is not required, and the method is insensitive to the strong broadband variability of the host star. Precise calibration of the spectral features of the host star may only be attainable by obtaining deep observations of the system during inferior conjunction that serve as a reference. The high-pass filter spectroscopic technique with the MIRI MRS can be tested on warm Jupiters, Neptunes, and super-Earths with significantly higher planet/star contrast ratios than the Proxima system.
Adding the s-Process Element Cerium to the APOGEE Survey: Identification and Characterization of Ce ii Lines in the H-band Spectral Window
Authors: Cunha Katia , Smith Verne V. , Hasselquist Sten , Souto Diogo , Shetrone Matthew D. , Allende Prieto Carlos , Bizyaev Dmitry , Frinchaboy Peter , García-Hernández D. Anibal , Holtzman Jon , Johnson Jennifer A. , Jőnsson Henrik , Majewski Steven R. , Mészáros Szabolcs , Nidever David , Pinsonneault Mark , Schiavon Ricardo P. , Sobeck Jennifer , Skrutskie Michael F. , Zamora Olga , Zasowski Gail , Fernández-Trincado J. G. 
Published: August 2017

Abstract
Nine Ce ii lines have been identified and characterized within the spectral window observed by the Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey (between λ1.51 and 1.69 μm). At solar metallicities, cerium is an element that is produced predominantly as a result of the slow capture of neutrons (the s-process) during asymptotic giant branch stellar evolution. The Ce ii lines were identified using a combination of a high-resolution (

) Fourier Transform Spectrometer (FTS) spectrum of α Boo and an APOGEE spectrum (R = 22,400) of a metal-poor, but s-process enriched, red giant (2M16011638-1201525). Laboratory oscillator strengths are not available for these lines. Astrophysical gf-values were derived using α Boo as a standard star, with the absolute cerium abundance in α Boo set by using optical Ce ii lines that have precise published laboratory gf-values. The near-infrared Ce ii lines identified here are also analyzed, as consistency checks, in a small number of bright red giants using archival FTS spectra, as well as a small sample of APOGEE red giants, including two members of the open cluster NGC 6819, two field stars, and seven metal-poor N- and Al-rich stars. The conclusion is that this set of Ce ii lines can be detected and analyzed in a large fraction of the APOGEE red giant sample and will be useful for probing chemical evolution of the s-process products in various populations of the Milky Way.
A Millennium-long Evolution of the 1 yr Recurrence Period Nova—Search for Any Indication of the Forthcoming He Flash
Authors: Kato Mariko , Saio Hideyuki , Hachisu Izumi 
Published: August 2017

Abstract
We present 1500 cycles of hydrogen shell flashes on a

white dwarf (WD) for a mass accretion rate of

yr−1, the mass ejection of which is calculated consistently with the optically thick winds. This model mimics the 1 yr recurrence period nova M31N 2008-12a. Through these hydrogen flashes a helium ash layer grows in mass and eventually triggers a helium nova outburst. Each hydrogen flash is almost identical, and there is no precursor for the forthcoming He flash either in the outburst or in the quiescent until the next He flash suddenly occurs. Thus, M31N 2008-12a is a promising candidate of He novae, outbursting in any time within a millennium. The prompt X-ray flash of He nova lasts as short as 15 minutes, with the X-ray luminosity being about half of the Eddington luminosity, making the observation difficult. In the very early phase of a He flash, the uppermost H-rich layer is convectively mixed into the deep interior and most of the hydrogen is consumed by nuclear burning. In comparison with hydrogen shell flashes of M31N 2008-12a, we expect the forthcoming He nova to have a very short prompt X-ray flash (15 minutes), a very bright optical/near-IR peak (∼3.5 mag brighter than M31N 2008-12a), a much longer nova duration (

yr), and a longer supersoft X-ray source phase (40–50 days or more).
A Search for Fast Radio Bursts with the GBNCC Pulsar Survey
Authors: Chawla P. , Kaspi V. M. , Josephy A. , Rajwade K. M. , Lorimer D. R. , Archibald A. M. , DeCesar M. E. , Hessels J. W. T. , Kaplan D. L. , Karako-Argaman C. , Kondratiev V. I. , Levin L. , Lynch R. S. , McLaughlin M. A. , Ransom S. M. , Roberts M. S. E. , Stairs I. H. , Stovall K. , Swiggum J. K. , Leeuwen J. van 
Published: August 2017

Abstract
We report on a search for fast radio bursts (FRBs) with the Green Bank Northern Celestial Cap (GBNCC) Pulsar Survey at 350 MHz. Pointings amounting to a total on-sky time of 61 days were searched to a dispersion measure (DM) of 3000 pc cm−3, while the rest (23 days; 29% of the total time) were searched to a DM of 500 pc cm−3. No FRBs were detected in the pointings observed through 2016 May. We estimate a 95% confidence upper limit on the FRB rate of

FRBs sky−1 day−1 above a peak flux density of 0.63 Jy at 350 MHz for an intrinsic pulse width of 5 ms. We place constraints on the spectral index α by running simulations for different astrophysical scenarios and cumulative flux density distributions. The nondetection with GBNCC is consistent with the 1.4 GHz rate reported for the Parkes surveys for α > +0.35 in the absence of scattering and free–free absorption and α > −0.3 in the presence of scattering, for a Euclidean flux distribution. The constraints imply that FRBs exhibit either a flat spectrum or a spectral turnover at frequencies above 400 MHz. These constraints also allow estimation of the number of bursts that can be detected with current and upcoming surveys. We predict that CHIME may detect anywhere from several to ∼50 FRBs per day (depending on model assumptions), making it well suited for interesting constraints on spectral index, the log N–log S slope, and pulse profile evolution across its bandwidth (400–800 MHz).
Evaluation of pathogenicity islands in uropathogenic Escherichia coli isolated from patients with urinary catheters
Authors: Firoozeh Farzaneh , Soleimani-Moorchekhorti Leila , Zibaei Mohammad 
Published: August 2017

Introduction: Uropathogenic Escherichia coli (UPEC), an important causative agent of urinary tract infections (UTIs), carries virulence factors which are clustered on pathogenicity islands (PAIs). The goal of this study was to characterize the PAIs among the UPEC isolated from patients with urinary catheters.
Methodology: A descriptive cross-sectional study was designed and from December 2014 to April 2015, 78 non-duplicate E. coli were collected from hospitalized patients with UTIs, including patients with and without indwelling urinary catheters. Two multiplex polymerase chain reaction (PCR) assays were performed to evaluate the presence of the eight most studied PAIs (I 536, II 536, III 536, IV536, I CFT073, II CFT073, PAI IJ96, and PAI IIJ96).
Results: Of 78 patients with a UTI 31 (39.7%) used indwelling catheters. Of these 31 patients, 27 (87.1%) carried PAIs markers, including 25 (80.6%) PAI IV536, 12 (38.7%) PAI ICFT073, 6 (19.4%) PAI IICFT073, 6 (19.4%) PAI III536 and 3 (9.7%) PAI II536. PAI I536, PAI IJ96, and PAI IIJ96 were not detected in the UPEC strains.
Conclusions: The findings of this study revealed that the frequency of PAI markers in UPEC isolates from patients with indwelling urinary catheters was high. The rate of multiple PAIs carriage was notable among those patients, suggesting that UPEC strains that colonize the indwelling urinary catheters have the potential to cause complicated urinary infections. PAI ICFT073, which was found in association with pyelonephritis, prostatitis, and sepsis, could be considered as a target for medical interventions.
Molecular and phenotypic typing of enteropathogenic Escherichia coli isolated in childhood acute diarrhea in Abuja, Nigeria
Authors: Ifeanyi Casmir Ifeanyichukwu Cajetan , Ikeneche Nkiruka Florence , Bassey Bassey Enya , Morabito Stefano , Graziani Caterina , Caprioli Alfredo 
Published: August 2017

Introduction: Enteropathogenic Escherichia coli (EPEC) causes infectious diarrhea among children in developing countries. However, in Nigeria, due to limited laboratory resources, the genetic diversity of its virulence factors, which include intimin subtypes, remains undefined.
Methodology: EPEC isolates from diarrheic children 60 months of age and younger in Abuja, Nigeria, were analyzed. Polymerase chain reaction (PCR) for EPEC virulence gene, Hep-2 cell adherence, and serotyping were performed. EPEC strains were further subtyped by PCR for the identification of intimin subtype genes α (alpha), β (beta), γ1 (gamma-1), and έ (epsilon). Antibiotic resistance and extended-spectrum beta-lactamase (ESBL) production was determined by Clinical and Laboratory Standards Institute guidelines.
Results: Overall, 18 (4.5%) out of 400 children with acute diarrhea had EPEC infection. Typical EPEC (tEPEC) strains were detected in 14 (3.5%), whereas 4 (1.1%) were atypical EPEC (aEPEC). A total of 15 (83.3%) of the EPEC isolated belonged to β intimin subtype gene, while the remaining 3 EPEC isolates possessed the intimin έ subtype. No α and γ intimin subtypes were detected. Traditional EPEC serotypes O114:H14 were detected only in tEPEC strains. Marked resistance to β-lactam agents were observed but no ESBL-producing tEPEC or aEPEC was detected.
Conclusions: This is the first report of intimin subtype genes in Abuja, Nigeria. EPEC isolates of diverse serotypes resistant to β-lactam antimicrobial agents were observed. These data will be useful in facilitating the characterization of intimin variants of EPEC and some Shiga toxin-producing E. coli (STEC) in humans and other animal species.