bluuebunny/crossref_metadata_2025_split huggingface dataset:
Room‐Temperature‐Operated Ultrasensitive Broadband Photodetectors by Perovskite Incorporated with Conjugated Polymer and Single‐Wall Carbon Nanotubes
Authors: Xu Wenzhan , Guo Yikun , Zhang Xiaotao , Zheng Luyao , Zhu Tao , Zhao Dahui , Hu Wenping , Gong Xiong 
Published: December 2017

AbstractIn this work, room‐temperature‐operated ultrasensitive solution‐processed perovskite photodetectors (PDs) with near infrared (NIR) photoresponse are reported. In order to enable perovskite PDs possessing extended NIR photoresponse, novel n‐type low bandgap conjugated polymer, poly[(N,N′‐bis(2‐octyldodecyl)‐1,4,5,8‐naphthalene diimide‐2,6‐diyl) (2,5‐dioctyl‐3,6‐di(thiophen‐2‐yl)pyrrolo[3,4‐c]pyrrole‐1,4‐dione‐5,5′‐diyl)] (NDI‐DPP), which has strong absorption in the NIR region, is developed and then employed in perovskite PDs. By the formation of type II band alignment between NDI‐DPP with single‐wall carbon nanotubes (SWCNTs), the NIR absorption of NDI‐DPP is exploited, which contributes to the NIR photoresponse for the perovskite PDs, where perovskite is incorporated with NDI‐DPP and SWCNTs as well. In addition, SWCNTs incorporated with perovskite active layer can offer the percolation pathways for high charge‐carrier mobility, which tremendously boosts the charge transfer in the photoactive layer, and consequently improves the photocurrent in the visible region. As a result, the perovskite PDs exhibit the responsivities of ≈400 and ≈150 mA W−1 and the detectivities of over 6 × 1012 Jones (1 Jones = 1 cm Hz1/2 W−1) and over 2 × 1012 Jones in the visible and NIR regions, respectively. This work reports the development of perovskite PDs with NIR photoresponse, which is terrifically beneficial for the practical applications of perovskite PDs.
Substituted Hantzsch Esters as Versatile Radical Reservoirs in Photoredox Reactions
Authors: Gu Fangjun , Huang Wenhao , Liu Xu , Chen Wenxin , Cheng Xu 
Published: December 2017

AbstractSubstituted Hantzsch esters can act as radical reservoirs in photoredox reactions, steadily releasing a carbon radical and a hydrogen atom radical in the absence of an additional electron acceptor. We propose that radical release by substituted Hantzsch esters occurs via a mechanism involving an internal redox cycle. Cinnamidecinnamides, styrenes, α,β‐unsaturated acids, and diarylethenes could be alkylated smoothly with these reagents.magnified image
Inadequate brain glycogen or sleep increases spreading depression susceptibility
Authors: Kilic Kivilcim , Karatas Hulya , Dönmez‐Demir Buket , Eren‐Kocak Emine , Gursoy‐Ozdemir Yasemin , Can Alp , Petit Jean‐Marie , Magistretti Pierre J. , Dalkara Turgay 
Published: December 2017

ObjectiveGlycogen in astrocyte processes contributes to maintenance of low extracellular glutamate and K+ concentrations around excitatory synapses. Sleep deprivation (SD), a common migraine trigger, induces transcriptional changes in astrocytes, reducing glycogen breakdown. We hypothesize that when glycogen utilization cannot match synaptic energy demand, extracellular K+ can rise to levels that activate neuronal pannexin‐1 channels and downstream inflammatory pathway, which might be one of the mechanisms initiating migraine headaches.MethodsWe suppressed glycogen breakdown by inhibiting glycogen phosphorylation with 1,4‐dideoxy‐1,4‐imino‐D‐arabinitol (DAB) and by SD.ResultsDAB caused neuronal pannexin‐1 large pore opening and activation of the downstream inflammatory pathway as shown by procaspase‐1 cleavage and HMGB1 release from neurons. Six‐hour SD induced pannexin‐1 mRNA. DAB and SD also lowered the cortical spreading depression (CSD) induction threshold, which was reversed by glucose or lactate supplement, suggesting that glycogen‐derived energy substrates are needed to prevent CSD generation. Supporting this, knocking down the neuronal lactate transporter MCT2 with an antisense oligonucleotide or inhibiting glucose transport from vessels to astrocytes with intracerebroventricularly delivered phloretin reduced the CSD threshold. In vivo recordings with a K+‐sensitive/selective fluoroprobe, Asante Potassium Green‐4, revealed that DAB treatment or SD caused a significant rise in extracellular K+ during whisker stimulation, illustrating the critical role of glycogen in extracellular K+ clearance.InterpretationSynaptic metabolic stress caused by insufficient glycogen‐derived energy substrate supply can activate neuronal pannexin‐1 channels as well as lower the CSD threshold. Therefore, conditions that limit energy supply to synapses (eg, SD) may predispose to migraine attacks, as suggested by genetic studies associating glucose or lactate transporter deficiency with migraine. Ann Neurol 2018;83:61–73
Synthesis and Reactivity of the Phosphorus Analogues of Cyclopentadienone, Tricyclopentanone, and Housene
Authors: Krachko Tetiana , Ehlers Andreas W. , Nieger Martin , Lutz Martin , Slootweg J. Chris 
Published: December 2017

AbstractThe phosphorus analogues of cyclopentadienone, tricyclopentanone, and housene were accessed from bis(cyclopropenyl)diphosphetanedione 3, which was prepared by mixing 1,2,3‐tris‐tert‐butylcyclopropenium tetrafluoroborate (1) and sodium phosphaethynolate [Na(OCP)(dioxane)n]. While photolysis of 3 results in decarbonylation, yielding bis(cyclopropenyl)diphosphene 4 and after rearrangement diphosphahousene 5, thermolysis of 3 leads to phosphatricyclo[2.1.0.0]pentanone 7. Metal‐mediated valence isomerization of 7 and subsequent demetalation provides access to phosphacyclopentadienone 12.
Substance P in Dorsal Root Ganglion Neurons in Young and Adult Rats, after Nociceptive Stimulation during the Neonatal Period
Authors: Simões Ana Leda Bertoncini , Silva Greice Anne Rodrigues , Giorgetto Carolina , de Cassia do Carmo‐Campos Elisabete , Dias Fernando José , Fazan Valéria Paula Sassoli 
Published: December 2017

ABSTRACTThe nervous system is highly plastic during the neonatal period, being sensitive to noxious stimuli, which may cause short‐ and long‐term pain responsivity changes. Understanding plasticity in peripheral pain pathways is crucial, particularly when the nervous system is still under development and remodeling process. Substance P (SP) is widely used as a marker for peripheral neurons with unmyelinated and small myelinated fibers. We investigated the number of SP immunoreactive neurons in the dorsal root ganglion (DRG) of male and female Wistar rats, 15 and 180 days after nociceptive stimulation during the neonatal period. Right and left 5th lumbar (L5) DRG were incubated in rabbit polyclonal anti‐substance P primary followed by biotinylated donkey anti‐rabbit secondary antibodies. Reaction was revealed with a nickel‐diaminobenzidine solution. Labeled neurons were counted and compared between ages, genders and groups. Gender differences were present in both ages, with the number of SP‐positive DRG neurons being larger in 15‐days‐old males on both sides. After 180 days, males showed a larger number of SP‐positive neurons than females only on the nociceptive stimulated side. An increased number of SP‐positive neurons in the DRG on the stimulated side was present in females, immediately after nociceptive stimulation, but not after 180 days. In conclusion, neonatal noxious stimulation caused a permanent increase in SP‐positive DRG neurons in males that was not observed in females, suggesting that differences in pain processing/responsivity between genders could be related to morphological alterations of the nervous system. Anat Rec, 301:849–861, 2018. © 2017 Wiley Periodicals, Inc.
Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD‐1, TIGIT, and TIM‐3 in Lymphocytes From Patients With Systemic Sclerosis
Authors: Fleury Michelle , Belkina Anna C. , Proctor Elizabeth A. , Zammitti Christopher , Simms Robert W. , Lauffenburger Douglas A. , Snyder‐Cappione Jennifer E. , Lafyatis Robert , Dooms Hans 
Published: December 2017

ObjectiveImmune dysfunction is an important component of the disease process underlying systemic sclerosis (SSc), but the mechanisms contributing to altered immune cell function in SSc remain poorly defined. This study was undertaken to measure the expression and function of the coinhibitory receptors (co‐IRs) programmed cell death 1 (PD‐1), T cell immunoglobulin and ITIM domain (TIGIT), T cell immunoglobulin and mucin domain 3 (TIM‐3), and lymphocyte activation gene 3 (LAG‐3) in lymphocyte subsets from the peripheral blood of patients with SSc.MethodsCo‐IR expression levels on subsets of immune cells were analyzed using a 16‐color flow cytometry panel. The functional role of co‐IRs was determined by measuring cytokine production after in vitro stimulation of SSc and healthy control peripheral blood mononuclear cells (PBMCs) in the presence of co‐IR–blocking antibodies. Supernatants from cultures of stimulated PBMCs were added to SSc fibroblasts, and their impact on fibroblast gene expression was measured. Mathematical modeling was used to reveal differences between co‐IR functions in SSc patients and healthy controls.ResultsLevels of the co‐IRs PD‐1 and TIGIT were increased, and each was coexpressed, in distinct T cell subsets from SSc patients compared to healthy controls. Levels of TIM‐3 were increased in SSc natural killer cells. PD‐1, TIGIT, and TIM‐3 antibody blockade revealed patient‐specific roles of each of these co‐IRs in modulating activation‐induced T cell cytokine production. In contrast to healthy subjects, blockade of TIGIT and TIM‐3, but not PD‐1, failed to reverse inhibited cytokine production in SSc patients, indicating that enhanced T cell exhaustion is present in SSc. Finally, cytokines secreted in anti–TIM‐3–treated PBMC cultures distinctly changed the gene expression profile in SSc fibroblasts.ConclusionThe altered expression and regulatory capacity of co‐IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine‐mediated cross‐talk of immune cells and fibroblasts at sites of inflammation and/or fibrosis.
Analysis, Verification and Comparison on Feedback‐Aided MA Equivalence and Zhang Equivalency of Minimum‐Kinetic‐Energy Type for Kinematic Control of Redundant Robot Manipulators
Authors: Qiu Binbin , Zhang Yunong , Yang Zhi 
Published: December 2017

AbstractBy following and generalizing Ma et al.'s inspiring work and Zhang et al.'s inspiring work, this paper proposes and investigates three kinds of equivalent relationships with error‐feedback information incorporated for the minimum‐kinetic‐energy (MKE) redundancy resolution. Specifically, these three equivalent relationships are divided into two big classes in terms of scheme formulations: one is termed MKE‐type Ma equivalence (MKE‐ME); the other is MKE‐type Zhang equivalency (MKE‐ZE), which can be further subdivided into MKE‐ZE‐I and MKE‐ZE‐II. Also, the equivalent analyses as well as the primary distinctions about three such equivalent relationships are presented. The simulation results based on a PUMA560 robot manipulator and a three‐link planar robot manipulator not only verify the efficacy of the corresponding velocity‐level and acceleration‐level schemes of MKE‐ME, MKE‐ZE‐I and MKE‐ZE‐II, but also substantiate their reasonableness and effectiveness of these three equivalent relationships. More importantly, the comparative numerical results show their respective characteristics and advantages for kinematic control of redundant robot manipulators.
Simultaneous quantification of multiple components in rat plasma by UPLC‐MS/MS and pharmacokinetic study after oral administration of Huangqi decoction
Authors: Zeng Jia‐Kai , Li Yuan‐Yuan , Wang Tian‐Ming , Zhong Jie , Wu Jia‐Sheng , Liu Ping , Zhang Hua , Ma Yue‐Ming 
Published: December 2017

AbstractA rapid, sensitive and accurate UPLC‐MS/MS method was developed for the simultaneous quantification of components of Huangqi decoction (HQD), such as calycosin‐7‐O‐β‐d‐glucoside, calycosin‐glucuronide, liquiritin, formononetin‐glucuronide, isoliquiritin, liquiritigenin, ononin, calycosin, isoliquiritigenin, formononetin, glycyrrhizic acid, astragaloside IV, cycloastragenol, and glycyrrhetinic acid, in rat plasma. After plasma samples were extracted by protein precipitation, chromatographic separation was performed with a C18 column, using a gradient of methanol and 0.05% acetic acid containing 4mm ammonium acetate as the mobile phase. Multiple reaction monitoring scanning was performed to quantify the analytes, and the electrospray ion source polarity was switched between positive and negative modes in a single run of 10 min. Method validation showed that specificity, linearity, accuracy, precision, extraction recovery, matrix effect and stability for 14 components met the requirements for their quantitation in biological samples. The established method was successfully applied to the pharmacokinetic study of multiple components in rats after intragastric administration of HQD. The results clarified the pharmacokinetic characteristics of multiple components found in HQD. This research provides useful information for understanding the relation between the chemical components of HQD and their therapeutic effects.
Action video gaming and the brain: fMRI effects without behavioral effects in visual and verbal cognitive tasks
Authors: Richlan Fabio , Schubert Juliane , Mayer Rebecca , Hutzler Florian , Kronbichler Martin 
Published: December 2017

AbstractIntroductionIn this functional magnetic resonance imaging (fMRI) study, we compared task performance together with brain activation in a visuospatial task (VST) and a letter detection task (LDT) between longtime action video gamers (N = 14) and nongamers (N = 14) in order to investigate possible effects of gaming on cognitive and brain abilities.MethodsBased on previous research, we expected advantages in performance for experienced action video gamers accompanied by less activation (due to higher efficiency) as measured by fMRI in the frontoparietal attention network.ResultsContrary to these expectations, we did not find differences in overall task performance, nor in brain activation during the VST. We identified, however, a significantly different increase in the BOLD signal from a baseline task to the LDT in action video gamers compared with nongamers. This increased activation was evident in a number of frontoparietal regions including the left middle paracingulate cortex, the left superior frontal sulcus, the opercular part of the left inferior frontal gyrus, and the left and right posterior parietal cortex. Furthermore, we found increased activation in the triangular part of the left inferior frontal gyrus in gamers relative to nongamers when activation during the LDT was compared with activation during the VST.ConclusionsIn sum, the expected positive relation between action video game experience and cognitive performance could not be confirmed. Despite their comparable task performance, however, gamers and nongamers exhibited clear‐cut differences in brain activation patterns presumably reflecting differences in neural engagement, especially during verbal cognitive tasks.
Bombesin receptor subtype‐3‐expressing neurons regulate energy homeostasis through a novel neuronal pathway in the hypothalamus
Authors: Maruyama Minoru , Hotta Natsu , Nio Yasunori , Hamagami Kenichi , Nagi Toshimi , Funata Masaaki , Sakamoto Junichi , Nakakariya Masanori , Amano Nobuyuki , Nishida Mayumi , Okawa Tomohiro , Arikawa Yasuyoshi , Sasaki Shinobu , Kasai Shizuo , Nagisa Yasutaka , Habata Yugo , Mori Masaaki 
Published: December 2017

AbstractObjectivesBombesin receptor subtype‐3 (BRS‐3) has been suggested to play a potential role in energy homeostasis. However, the physiological mechanism of BRS‐3 on energy homeostasis remains unknown. Thus, we investigated the BRS‐3‐mediated neuronal pathway involved in food intake and energy expenditure.Materials and MethodsExpression of BRS‐3 in the rat brain was histologically examined. The BRS‐3 neurons activated by refeeding‐induced satiety or a BRS‐3 agonist were identified by c‐Fos immunostaining. We also analyzed expression changes in feeding‐relating peptides in the brain of fasted rats administered with the BRS‐3 agonist.ResultsIn the paraventricular hypothalamic nucleus (PVH), dorsomedial hypothalamic nucleus (DMH), and medial preoptic area (MPA), strong c‐Fos induction was observed in the BRS‐3 neurons especially in PVH after refeeding. However, the BRS‐3 neurons in the PVH did not express feeding‐regulating peptides, while the BRS‐3 agonist administration induced c‐Fos expression in the DMH and MPA, which were not refeeding‐sensitive, as well as in the PVH. The BRS‐3 agonist administration changed the Pomc and Cart mRNA level in several brain regions of fasted rats.ConclusionThese results suggest that BRS‐3 neurons in the PVH are a novel functional subdivision in the PVH that regulates feeding behavior. As the MPA and DMH are reportedly involved in thermoregulation and energy metabolism, the BRS‐3 neurons in the MPA/DMH might mediate the energy expenditure control. POMC and CART may contribute to BRS‐3 neuron‐mediated energy homeostasis regulation. In summary, BRS‐3‐expressing neurons could regulate energy homeostasis through a novel neuronal pathway.
Vascular surgery of aortic thrombosis in a dog using Fogarty maneuver – technical feasibility
Authors: Schwede Maartje , Richter Olaf , Alef Michaele , Theuß Tobias , Loderstedt Shenja 
Published: December 2017

Key Clinical MessageAortic thromboembolism is a rare and life‐threatening disease in dogs. This report aims to describe the successful surgical treatment by use of a Fogarty Thrombectomy Catheter in an 8‐year‐old patient. The postsurgical intensive care therapy to prevent ischemia‐reperfusion syndrome is specified, despite poor outcome in our case (owner elected euthanasia).
In Situ Prepared Flexible 3D Polymer Film Photocatalyst for Highly Selective Solar Fuel Production from CO2
Authors: Yadav Rajesh K. , Kumar Abhishek , Yadav Dolly , Park No‐Joong , Kim Jae Young , Baeg Jin‐Ook 
Published: December 2017

AbstractThe conversion of CO2 to valuable solar fuels by means of solar energy using metal‐free flexible film photocatalysts is an appealing strategy. Here we demonstrate a three dimensional aromatic polymer (3DAP) derived from triptycene (TC) as a metal free, stable and highly efficient visible light responsive flexible film photocatalyst for selective solar fuel production from CO2. For this research work, the polymerization of TC by the Diels–Alder reaction is exploited for the first time as a new synthetic approach for the construction of three dimensional aromatic polymer photocatalyst. The visible‐light harvesting ability, band gap suitability, high Brunauer–Emmett–Teller (BET) surface area and electron transfer capability via interconnecting 3D chain of 3DAP contribute to the excellent performance of the film photocatalyst as evident from 91.09 % NADH regeneration and 225.12 μmol of formic acid production. This work provides important insights into the design of flexible polymer film photocatalyst for selective solar fuel formation from CO2 and is expected to trigger further interest in sustainable solar energy conversion applications such as tailorable and wearable devices.
New Electrode and Electrolyte Configurations for Lithium‐Oxygen Battery
Authors: Ulissi Ulderico , Elia Giuseppe Antonio , Jeong Sangsik , Reiter Jakub , Tsiouvaras Nikolaos , Passerini Stefano , Hassoun Jusef 
Published: December 2017

AbstractCathode configurations reported herein are alternative to the most diffused ones for application in lithium‐oxygen batteries, using an ionic liquid‐based electrolyte. The electrodes employ high surface area conductive carbon as the reaction host, and polytetrafluoroethylene as the binding agent to enhance the oxygen reduction reaction (ORR)/oxygen evolution reaction (OER) reversibility. Roll‐pressed, self‐standing electrodes (SSEs) and thinner, spray deposited electrodes (SDEs) are characterized in lithium‐oxygen cells using an ionic liquid (IL) based electrolyte formed by mixing lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) salt and N,N‐diethyl‐N‐(2‐methoxyethyl)‐N‐methylammonium bis(trifluoromethanesulfonyl)imide (DEMETFSI). The electrochemical results reveal reversible reactions for both electrode configurations, but improved electrochemical performance for the self‐standing electrodes in lithium‐oxygen cells. These electrodes show charge/discharge polarizations at 60 °C limited to 0.4 V, with capacity up to 1 mAh cm−2 and energy efficiency of about 88 %, while the spray deposited electrodes reveal, under the same conditions, a polarization of 0.6 V and energy efficiency of 80 %. The roll pressed electrode combined with the DEMETFSI‐LiTFSI electrolyte and a composite LixSn‐C alloy anode forms a full Li‐ion oxygen cell showing extremely limited polarization, and remarkable energy efficiency.
Fluorine‐Containing Silsesquioxane‐Based Hybrid Porous Polymers Mediated by Bases and Their Use in Water Remediation
Authors: Ge Mingtao , Liu Hongzhi 
Published: December 2017

AbstractTwo different silsesquioxane‐based porous polymers (FHPPs), namely FHPP‐1 and FHPP‐2, have been prepared, respectively, by changing the acid scavenger from sodium bicarbonate to triethylamine in the Heck reaction between octavinylsilsesquioxane (OVS) and 1,4‐dibromotetrafluorobenzene. It was observed that defluorination occurred in the case of triethylamine. FHPP‐1 possesses a higher surface area of 600 m2 g−1 and a hierarchical porous structure; in contrast, FHPP‐2 possesses a SBET value of 325 m2 g−1 and a microporous structure. This work provides a new approach to the preparation and tuning of fluorine‐containing porous polymers based on silsesquioxanes. These porous materials were employed to remove dyes and a heavy metal from water, showing good binding efficiencies.
Culprit plaque characteristics in women vs men with a first ST‐segment elevation myocardial infarction: In vivo optical coherence tomography insights
Authors: Sun Rong , Sun Liping , Fu Yandong , Liu Huimin , Xu Maoen , Ren Xuefeng , Yu Huai , Dong Hui , Liu Yang , Zhu Yinchun , Tian Jinwei , Yu Bo 
Published: December 2017

BackgroundIt is unclear whether more severe coronary atherosclerosis is a prerequisite to an initial acute coronary event in women vs men.HypothesisWomen may have more severe coronary atherosclerosis than men in patients with acute coronary event.MethodsWe used intravascular optical coherence tomography (OCT) to evaluate gender differences in culprit‐plaque morphology in patients with a first ST‐segment elevation myocardial infarction (STEMI).We retrospectively enrolled 211 consecutive patients who experienced a first STEMI and underwent an OCT examination of their infarct‐related artery before primary percutaneous coronary intervention.ResultsOf the 211 patients enrolled, 162 (76.7%) were men and 49 (23.2%) were women. The women were significantly older than the men (mean age, 60.2 ± 8.2 vs 55.7 ± 11.2 years; P = 0.01) and less likely to be current smokers (P = 0.02). Moreover, the delay from symptom onset to reperfusion was longer in women than in men (7.6 ± 6.1 vs 5.5 ± 4.4 hours; P = 0.01). The OCT data indicated that there were no gender differences in culprit‐plaque morphology, including lipid length, lipid arc, minimum fibrous cap thickness, or minimum lumen area. Additionally, no gender differences were found in the prevalence of plaque rupture, thin‐cap fibroatheroma, residual thrombus, microvessels, macrophages, cholesterol crystals, or calcification.ConclusionsAmong patients presenting with a first STEMI, there were no differences in culprit plaque features between women and men.