bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genomic insights into the virulence and salt tolerance of Staphylococcus equorum
Authors: Jeong Do-Won , Heo Sojeong , Ryu Sangryeol , Blom Jochen , Lee Jong-Hoon 
Published: July 2017

AbstractTo shed light on the genetic background behind the virulence and salt tolerance of Staphylococcus equorum, we performed comparative genome analysis of six S. equorum strains. Data on four previously published genome sequences were obtained from the NCBI database, while those on strain KM1031 displaying resistance to multiple antibiotics and strain C2014 causing haemolysis were determined in this study. Examination of the pan-genome of five of the six S. equorum strains showed that the conserved core genome retained the genes for general physiological processes and survival of the species. In this comparative genomic analysis, the factors that distinguish the strains from each other, including acquired genomic factors in mobile elements, were identified. Additionally, the high salt tolerance of strains enabling growth at a NaCl concentration of 25% (w/v) was attributed to the genes encoding potassium voltage-gated channels. Among the six strains, KS1039 does not possess any of the functional virulence determinants expressed in the other strains.
Capture of microparticles by bolus flow of red blood cells in capillaries
Authors: Takeishi Naoki , Imai Yohsuke 
Published: July 2017

AbstractPrevious studies have concluded that microparticles (MPs) can more effectively approach the microvessel wall than nanoparticles because of margination. In this study, however, we show that MPs are not marginated in capillaries where the vessel diameter is comparable to that of red blood cells (RBCs). We numerically investigated the behavior of MPs with a diameter of 1 μm in various microvessel sizes, including capillaries. In capillaries, the flow mode of RBCs shifted from multi-file flow to bolus (single-file) flow, and MPs were captured by the bolus flow of the RBCs instead of being marginated. Once MPs were captured, they rarely escaped from the vortex-like flow structures between RBCs. These capture events were enhanced when the hematocrit was decreased, and reduced when the shear rate was increased. Our results suggest that microparticles may be rather inefficient drug carriers when targeting capillaries because of capture events, but nanoparticles, which are more randomly distributed in capillaries, may be more effective carriers.
Biosemiotic conflict in communication
Authors: Askenasy Jean Jacques 
Published: July 2017

Maurice Merleau-Ponty and Y. Michael Barilan have described the conflictual aspects of human communication (Merleau-Ponty, 1967). Humans communicate through verbal language, body-language, and stereotypes. (I coined the term ‘phatic communication’ for stereotypes.) These 3 types of communication can be in harmony or conflict.Verbal (VC) and corporal (CC) communication are well known. During the past decade, I have examined the field of phatic communication (PC). Phatic communication consists of laughing, crying, yawning, sighing, gasping, sneezing and hiccupping, actions that date back over 500 million years to the Reptilia class of the animal kingdom. During the last million years, these biosemiotic actions have acquired psychological meanings in humans as a result of neocortex connections.The simultaneous presence of threatening verbal signs with empathic stereotype signs, such as violence with laughter or aggression with a smile, requires a rational / emotional effort to decide within milliseconds if the message is a threat or joke.
Engaging professionals with serious games: the Lean Healthcare Lab at Siena University Hospital
Authors: Barnabè Federico , Giorgino Maria Cleofe , Guercini Jacopo , Bianciardi Caterina , Mezzatesta Vincenzo 
Published: July 2017

Purpose
This paper aims to stimulate interest in the potentials of serious games within organizations. Through the examination of a case study, emphasis is given to serious games designed for health care (HC) organizations that are adopting lean thinking principles and tools.

Design/methodology/approach
The paper discusses how serious games can be designed and implemented in practice by describing a case study based on a HC organization. The program, now in its second year, has been used extensively to train HC professionals.

Findings
The article is based on the authors’ firsthand experience with serious games and the outcome of several projects carried out in the HC setting under analysis. Serious games were found to be powerful training and management development tools as well as engaging environments for professionals. Specifically, The Lean Healthcare Lab supported professionals in their use and implementation of several Lean principles and techniques.

Research limitations/implications
The article suggests the opportunity to evaluate the effectiveness of serious games also to improve team performance and develop leadership skills.

Practical implications
Serious games have an enormous potential in sustaining processes of both individual and organizational learning, as well as facilitating improved teamwork. Moreover, serious games are very effective educational tools when compared to more conventional programs.

Originality/value
The approach described in this study can be used to design and implement serious games in any type of organization, in particular, those employing highly skilled professionals. Additionally, this article highlights how serious games can provide learners with a simulated close-to-reality environment where they are challenged to develop policies and use a variety of Lean and management tools.
Digital archives from the ground up
Authors: Person Debora A. , Plumb Tawnya K. 
Published: July 2017

Purpose
For many years, the librarians at University of Wyoming’s George William Hopper Law Library fielded questions about the history of the law school and alumni. Unfortunately, no one collection of institutional historical documents was available to search for relevant answers. The result was a decision to collect historic materials in a digital archive to make them available to anyone in the law school who might field such inquiries and to preserve them for future interest. The purpose of this case study is to provide a blueprint for building a digital archives from the ground up.

Design/methodology/approach
The digital archive began with print-born historical documents, scanned as preservation copies and entered into a database of images and files to which searchable metadata could be added. In addition to historical materials, it was important to collect the materials that the law school and the law library were producing. Therefore, the project was twofold: collect, preserve and make searchable the printed historic materials in a digital environment and harvest, preserve and make searchable print-born and digital-born materials as part of an ongoing process. To do this, appropriate software had to be identified.

Findings
The following steps blueprint the building of an archive on a digital platform: establish the site’s internet address, title and description; select a look and feel template and personalize the archive; create collections; identify Dublin Core preferences; add items and files using controlled vocabulary; experiment with any available plugins; and promote and provide access to the archive.

Originality/value
The digital archives project initiated by the library has led to other initiatives and opportunities for service.
InDiPres: a statewide collaborative approach to digital preservation
Authors: May Cinda Ann 
Published: July 2017

Purpose
The purpose of this case study is to demonstrate how cultural memory organizations in Indiana used Library Services Technology Act grant funding as seed money to form a collaborative group to attain an affordable and sustainable digital preservation solution.

Design/methodology/approach
This case study relates how concern for digital content created across Indiana by an array of cultural memory organizations led to a multi-year quest to establish a community-based, cost-effective, open-source digital preservation solution to address a common problem.

Findings
Interest in a collaborative community-based digital preservation solution, especially among small- and mid-sized under-resourced organizations, exists across the spectrum of Indiana cultural heritage institutions, but education and commitment are key to the success of a statewide solution.

Originality/value
While focusing on cultural memory organizations in Indiana, the case study also provides information about the process of establishing a digital preservation collaborative to leverage resources to provide a cost-effective and sustainable long-term solution, particularly for small- to mid-sized institutions.
Social entrepreneurship orientation: development of a measurement scale
Authors: Kraus Sascha , Niemand Thomas , Halberstadt Jantje , Shaw Eleanor , Syrjä Pasi 
Published: July 2017

Purpose
Despite growing scholarly interest in social entrepreneurs and the social enterprises (SE) they create, few studies have examined the hybridity of SE including, surprisingly, whether they adopt an entrepreneurial orientation (EO). One explanation for this may be the continuing lack of an appropriate scale measuring social entrepreneurship orientation (SEO). The purpose of this paper is to address this research gap by proposing an initial SEO scale based on input from scholars in the fields of entrepreneurship and social entrepreneurship.

Design/methodology/approach
This study employed mixed methods and a two stage design. In stage 1, a Delphi study with 18 researchers with expertise of investigating entrepreneurship and social entrepreneurship was used to generate constructs combining aspects of both social and EOs. In stage 2, the authors assessed the face validity of the derived items from the Delphi study by conducting a survey with 82 such experts.

Findings
This paper provides fresh empirical insights into how SEO can be measured by proposing, for the first time, a 12 item scale with four dimensions for the first time.

Research limitations/implications
The authors recommend that future studies employ quantitative methods, particularly with firms exhibiting differing levels of the “socialness” dimension which the authors propose and that such studies involve a variety of research informants. Statistical analysis of data collected across large sample sizes will help evaluate the reliability and validity of the scale which the authors propose.

Practical implications
This paper includes implications for future research based on the proposed SEO measurement scale.

Originality/value
This paper develops the first SEO scale based on empirical data collected from experts in the fields of entrepreneurship and social entrepreneurship.
Research suggestions for management, spirituality, religion
Authors: Petrosko Joseph M. , Alagaraja Meera 
Published: July 2017

Purpose
The purpose of the paper is to suggest effective choices for key decisions when pursuing a programmatic research strategy in management, spirituality and religion (MSR). An example is provided of how the suggestions can be used.

Design/methodology/approach
Suggestions for research were gleaned from current sources in research methodology. The example provided was a study of 398 employees who were surveyed on spirituality, job satisfaction and intent to leave their job. Structural equation modeling (SEM) was used to test three research hypotheses.

Findings
Using item analysis, exploratory factor analysis and SEM can be a way to pursue research using variables related to spirituality and religion.

Originality/value
A programmatic research strategy employing SEM can effectively model how spirituality/religious variables directly and indirectly affect outcomes significant to the organization.
A bibliometric analysis of emergency management using information systems (2000-2016)
Authors: Du Helen S. , Ke Xiaobo , Chu Samuel K.W. , Chan Lok Ting 
Published: July 2017

Purpose
The purpose of this paper is to present a statistical analysis of research into emergency management (EM) using information systems (IS) for the period 2000-2016.

Design/methodology/approach
In this study, research trends in the area of EM using IS are analysed using various parameters, including trends on publications and citations, disciplinary distribution, journals, research institutions and regional cooperation. Through a keyword co-occurrence analysis, this study identifies the evolution of the main keywords in this area, and examines the changes and developments in the main focus of scholars in this period. The study also explores the main research orientations in the field by analysing and integrating the results of two cluster analyses conducted from keyword- and reference-based perspectives, respectively.

Findings
The area of EM using IS has received increased attention and interest by researchers and practitioners. It is suggested that more cooperation among research institutions is required to help facilitate the further development of the area. Six main research orientations are identified: namely Web 2.0-enabled research, geographic information technology (IT), IT-based research, the contextual use of IT, crisis collaboration research and mass media communication research, since the research area first became popular in 2006.

Originality/value
This study is the first to comprehensively map the landscape of EM by conducting a bibliometric analysis of the research using IS. The authors’ findings can help academics and emergency managers gain a comprehensive understanding of the research area, and guide scholars towards producing more effective findings.
Adverse drug reaction early warning using user search data
Authors: Shang Wei , Chen Hsinchun , Livoti Christine 
Published: July 2017

PurposeThe purpose of this paper is to propose a framework to detect adverse drug reactions (ADRs) using internet user search data, so that ADR events can be identified early. Empirical investigation of Avandia, a type II diabetes treatment, is conducted to illustrate how to implement the proposed framework.Design/methodology/approachTypical ADR identification measures and time series processing techniques are used in the proposed framework. Google Trends Data are employed to represent user searches. The baseline model is a disproportionality analysis using official drug reaction reporting data from the US Food and Drug Administration’s Adverse Event Reporting System.FindingsResults show that Google Trends series of Avandia side effects search reveal a significant early warning signal for the side effect emergence of Avandia. The proposed approach of using user search data to detect ADRs is proved to have a longer leading time than traditional drug reaction discovery methods. Three more drugs with known adverse reactions are investigated using the selected approach, and two are successfully identified.Research limitations/implicationsValidation of Google Trends data’s representativeness of user search is yet to be explored. In future research, user search in other search engines and in healthcare web forums can be incorporated to obtain a more comprehensive ADR early warning mechanism.Practical implicationsUsing internet data in drug safety management with a proper early warning mechanism may serve as an earlier signal than traditional drug adverse reaction. This has great potential in public health emergency management.Originality/valueThe research work proposes a novel framework of using user search data in ADR identification. User search is a voluntary drug adverse reaction exploration behavior. Furthermore, user search data series are more concise and accurate than text mining in forums. The proposed methods as well as the empirical results will shed some light on incorporating user search data as a new source in pharmacovigilance.
Research on the microstructure and properties of the overhanging structure formed by selective laser melting
Authors: Sun Jianfeng , Yang Zhou , Yang Yongqiang , Wang Di 
Published: July 2017

Purpose
This paper aims to analyze the different between matrix and overhanging structure and indicate the laws and mechanism of overhanging structure formed by selective laser melting (SLM).

Design/methodology/approach
This paper includes processing the matrix and overhanging structure with optimized parameters and analyzing the microstructure and properties of matrix and overhanging with OM, SEM, XRD etc. so as to analyze and reveal the laws and mechanism of overhanging structure formed by SLM.

Findings
The solidification of overhanging structure begins from the structure’s edge and extends to its center; the distribution of the Cr with a diameter of 250 nm in the Fe matrix is uniform; the grain in the overhanging structure is growing faster than the grain in the matrix. The overhanging structure mainly composed by austenite has no apparent layer. Moreover, the microhardness of the overhanging structure is 258.6-294.0 Hv0.3, smaller than the microhardness of the matrix which is 236.4-300.9 Hv0.3.

Originality/value
This paper clarifies how to manufacture overhanging structure and non-overhanging structure matrix with optimized parameters, analyzes the microstructures and compares the properties of both overhanging structure and non-overhanging structure “matrix”, so as to analyze the reasons for the forming of the overhanging structure, which in turn lauds basic data foundation for the theoretical studies in the future.
Uncertainty analysis and probabilistic segmentation of electrical resistivity images: the 2D inverse problem
Authors: Fernández‐Martínez Juan Luis , Xu Shan , Sirieix Colette , Fernández‐Muniz Zulima , Riss Joëlle 
Published: July 2017

ABSTRACTIn this paper, we present the uncertainty analysis of the 2D electrical tomography inverse problem using model reduction and performing the sampling via an explorative member of the Particle Swarm Optimization family, called the Regressive‐Regressive Particle Swarm Optimization. The procedure begins with a local inversion to find a good resistivity model located in the nonlinear equivalence region of the set of plausible solutions. The dimension of this geophysical model is then reduced using spectral decomposition, and the uncertainty space is explored via Particle Swarm Optimization. Using this approach, we show that it is possible to sample the uncertainty space of the electrical tomography inverse problem. We illustrate this methodology with the application to a synthetic and a real dataset coming from a karstic geological set‐up. By computing the uncertainty of the inverse solution, it is possible to perform the segmentation of the resistivity images issued from inversion. This segmentation is based on the set of equivalent models that have been sampled, and makes it possible to answer geophysical questions in a probabilistic way, performing risk analysis.
Effectiveness of 8‐ or 12‐weeks of ledipasvir and sofosbuvir in real‐world treatment‐naïve, genotype 1 hepatitis C infected patients
Authors: Curry M. P. , Tapper E. B. , Bacon B. , Dieterich D. , Flamm S. L. , Guest L. , Kowdley K. V. , Lee Y. , Milligan S. , Tsai N. , Younossi Z. , Afdhal N. H. 
Published: July 2017

SummaryBackgroundTreatment of genotype 1 hepatitis C virus (HCV) infection with combination direct acting anti‐virals is associated with very high rates of sustained virological response (SVR). Daily combination of ledipasvir and sofosbuvir for 12 weeks is approved for the treatment of genotype 1 HCV patients, though noncirrhotic patients who are naïve to treatment with a baseline HCV RNA <6 million IU/mL can be treated for 8 weeks. This guidance stemmed from a post hoc analysis of the ION 3 clinical trial, which demonstrated similar SVR for patients treated with ledipasvir and sofosbuvir with or without ribavirin for 8 or 12 weeks.AimTo compare the SVR for 8 weeks vs 12 weeks of ledipasvir and sofosbuvir in HCV infected patients in a real‐world setting.MethodsWe performed an observational real‐world cohort study of treatment success following 8 or 12 weeks of ledipasvir and sofosbuvir for treatment‐naïve genotype 1 HCV patients.ResultsA total of 826 patients were treated for either 8 (n=252) or 12 weeks (n=574) with ledipasvir and sofosbuvir and achieved SVR rate of 95.3% and there was no statistical difference in SVR rates in the two groups irrespective of any clinical or virological variables.ConclusionsIn treatment‐naïve HCV genotype 1 patients, SVR was 95% in those treated for either 8 weeks or 12 weeks with ledipasvir and sofosbuvir. 8 week ledipasvir and sofosbuvir can reduce costs without compromising outcomes for those patients who qualify for such regimen.
Roadsides: an opportunity for biodiversity conservation
Authors: Arenas Juan M. , Escudero Adrián , Mola Ignacio , Casado Miguel A. 
Published: July 2017

AbstractQuestionsHow do roadsides interact with patches of natural vegetation in shaping perennial plant communities in fragmented agricultural areas? Are the observed differences due to the type of roadside (i.e. roadcuts, embankments or road verges) or are there other factors driving community structure and composition?LocationStretch of motorway A3 and its surrounding area, central Spain.MethodsWe analysed the variation in perennial plant species composition and diversity among 92 plots (400 m2). The plots were located in five different environmental scenarios, three of them in a fragmented landscape (patches of natural vegetation, embankments and roadcuts) and two in an unfragmented landscape (natural vegetation and road verges). In each plot, the cover of each perennial plant species and eight soil variables were assessed. We used phi coefficient of correlation to determine the scenario preferences of each species, Kruskal–Wallis tests to compare the soil variables between landscape scenarios and eight descriptive variables of the community, and RDA and partial RDA to evaluate the relative importance of the type of environmental scenario on the floristic community.ResultsWe identified 130 species, with only 16 species never appearing on roadsides. Perennial total cover, species richness, inverse Simpson's index and number of protected species showed no significant differences between the five scenarios considered. In contrast, the number of nutrient‐demanding species and restricted‐range diversity had lower values in natural vegetation plots. Soil variables and the type of scenario together explained 28.5% of the species composition variation. Of this percentage, 6.8% was explained by soil variables, 12.1% by the type of scenario and 10.0% of the variation was shared between the two data sets.ConclusionsOur results show that almost all perennial species occurring in natural vegetation patches were also able to reach and settle in roadsides. However, soil conditions and other specific roadside variables generate different plant communities. In spite of the differences found between the perennial plant community of roadsides and their surrounding area, roadsides are excellent reservoirs of biodiversity.
Proper‐Function Moral Realism
Authors: Wisdom Jeffrey 
Published: July 2017

AbstractA common line of thought in contemporary metaethics is that certain facts about the evolutionary history of humans make moral realism implausible. Two of the most developed evolutionary cases against realism are found in the works of Richard Joyce and Sharon Street. In what follows, I argue that a form of moral realism that I call proper‐function moral realism can meet Joyce and Street's challenges. I begin by sketching the basics of proper‐function moral realism. I then present what I take to be the essence of Street's and Joyce's objections, and I show how proper‐function realism answers them.