bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of SST to forecast ionospheric delays using GPS observations
Authors: Gampala Sivavaraprasad , Devanaboyina Venkata Ratnam 
Published: February 2017

The temporal variations of ionospheric total electron content (TEC) due to space weather events compromise the precision of the global navigation satellite system (GNSS) measurements. The vulnerability of GNSS services to ionospheric delay can be studied using TEC datasets. Hence, in this study, the ionospheric TEC measured during 1 January 2013–31 December 2013 from global positioning system receiver located at a low‐latitude station, KL University, Vaddeswaram, Guntur, India (16.31°N, 80.37°E) has been processed and analysed using synchrosqueezing transform (SST). SST is a wavelet‐based adaptive time–frequency analysis tool. The performance of SST with an autoregressive moving average (ARMA) model is analysed and validated. Its potential in decomposing and forecasting ionospheric delay for an hour in advance has been exploited. It is observed that the hybrid ARMA with SST, i.e. the SST‐ARMA model is 4% more accurate in forecasting ionospheric variations than the model ARMA and 46% more accurate than the wavelet transform‐ARMA model for the 91 days of TEC dataset (April–June 2013). The forecast results during various geomagnetic conditions of 24th solar maximum period (2013) indicate that SST‐ARMA has the potential to be a useful tool to set up early warning systems for ionospheric disturbances.
Summability estimates on transport densities with Dirichlet regions on the boundaryviasymmetrization techniques
Authors: Dweik Samer , Santambrogio Filippo 
Published: February 2017

In this paper we consider the mass transportation problem in a bounded domain Ωwhere a positive mass f+in the interior is sent to the boundary∂Ω. This problems appears, for instance in some shape optimization issues. We prove summability estimates on the associated transport densityσ, which is the transport density from a diffuse measure to a measure on the boundary f− = P#f+(Pbeing the projection on the boundary), hence singular.Viaa symmetrization trick, as soon as Ωis convex or satisfies a uniform exterior ball condition, we prove Lpestimates (iff+ ∈ Lp, thenσ ∈ Lp). Finally, by a counter-example we prove that if f+ ∈ L∞ (Ω) and f−has bounded density w.r.t. the surface measure on∂Ω, the transport density σbetween f+and f−is not necessarily inL∞ (Ω), which means that the fact that f− = P#f+is crucial.
Evaluation of the Relationship between Age and Outcome after Microvascular Reconstruction among Patients with Recurrent Head and Neck Squamous Cell Carcinoma
Authors: Patel Viraj , Stern Carrie , Miglani Amar , Weichman Katie , Lin Juan , Ow Thomas , Garfein Evan 
Published: February 2017

Background In patients with head and neck squamous cell carcinoma (HNSCC), disease recurrence remains a significant obstacle to long-term survival. If possible, surgical salvage with reconstruction remains the best treatment option for patients with recurrence. Currently, there is no literature discussing whether age should preclude microvascular reconstruction in these patients. We hypothesize that older age alone does not affect outcomes.
Methods A retrospective chart review of patients with HNSCC at our institution between 2008 and 2015 was performed. Patients were included if they underwent simultaneous resection and flap reconstruction for recurrent HNSCC. Data collected included age, sex, primary site, type of reconstruction, previous treatments, postoperative complications (systemic and reconstructive), and overall survival.
Results A total of 65 patients met inclusion criteria for the review: 42 (64.6%) patients ≤70 years and 23 (35.4%) patients > 70 years. Overall survival was not significantly different between the younger and older groups (p = 0.199). Five-year survival was 60.1% in the younger group and 46.8% in the older group. No significant difference was found in reconstructive complication rates (p = 0.179) or systemic complication rates (p = 0.241) between the two groups. Multivariate logistic regression analysis further showed no significant association between patients' age (≤70 years or > 70 years) and reconstructive complications (p = 0.396) or systemic complications (p = 0.119).
Conclusion Age is not significantly associated with complications among patients undergoing resection and reconstruction for recurrent HNSCC. Microvascular reconstruction remains a feasible option in older patients with recurrent HNSCC. Advanced age alone should not preclude the surgical management of recurrent HNSCC.
Treatment Options for Bilateral Autologous Breast Reconstruction in Patients with Inadequate Donor-Site Volume
Authors: Chu Michael , Samra Fares , Kanchwala Suhail , Momeni Arash 
Published: February 2017

AbstractMore than 250,000 women will be diagnosed with invasive breast cancer in the United States in 2017 alone. A large number of these patients will undergo mastectomy and will be candidates for immediate breast reconstruction. The most common reconstructive options are either implant-based or autologous tissue reconstruction, with the latter having been reported to have higher rates of long-term patient satisfaction, lower cost, and less postoperative pain. A subset of patients, however, may not be ideal candidates for autologous microsurgical reconstruction, for example, due to inadequate abdominal tissues, yet they may desire this reconstructive modality. This is particularly challenging in patients requiring bilateral reconstructions. In this article, the authors discuss the various reconstructive modalities that can be considered in patients who desire bilateral breast reconstruction, are not ideal candidates for autologous reconstruction, yet do not wish to rely solely on implant-based modalities.
The Effects of Omega-3 Fatty Acids Supplementation on Gene Expression Involved in the Insulin and Lipid Signaling Pathway in Patients with Polycystic Ovary Syndrome
Authors: Nasri Khadijeh , Hantoushzadeh Sedigheh , Aghadavod Esmat , Taghizadeh Mohsen , Asemi Zatollah 
Published: February 2017

AbstractLimited data are available evaluating the effects of omega-3 fatty acids supplementation on gene expression involved in the insulin and lipid-signaling pathway in women with polycystic ovary syndrome (PCOS). This study was conducted to evaluate the effects of omega-3 fatty acids supplementation on gene expression involved in the insulin and lipid signaling pathway in women with PCOS. This randomized double blind, placebo-controlled trial was done among 60 women aged 18–40 years old and diagnosed with PCOS according to the Rotterdam criteria. Participants were randomly assigned into 2 groups to receive either 1 000 mg omega-3 fatty acids from flaxseed oil containing 400 mg α-linolenic acid (n=30) or placebo (n=30) twice a day for 12 weeks. Gene expressions involved in the insulin and lipid-signaling pathway were quantified in blood samples of PCOS women with RT-PCR method. Quantitative results of RT-PCR demonstrated that compared with the placebo, omega-3 fatty acids supplementation upregulated peroxisome proliferator-activated receptor gamma (PPAR-γ) mRNA (p=0.005) in peripheral blood mononuclear cells of women with PCOS. In addition, compared to the placebo, omega-3 fatty acids supplementation downregulated expressed levels of oxidized low-density lipoprotein receptor (LDLR) mRNA (p=0.002) in peripheral blood mononuclear cells of women with PCOS. We did not observe any significant effect of omega-3 fatty acids supplementation on expressed levels of glucose transporter 1 (GLUT-1) and lipoprotein(a) [Lp(a)] genes in peripheral blood mononuclear cells. Overall, omega-3 fatty acids supplementation for 12 weeks in PCOS women significantly improved gene expression of PPAR-γ and LDLR.
Einflussfaktoren auf die Standortwahl von hausärztlichen Land- und Stadtärzten in
Niedersachsen
Authors: Schmidt Katharina , Marten Ole , Kühne Christian , Zeidler Jan , Frank Martin 
Published: February 2017

Zusammenfassung
Hintergrund und Zielsetzung Die Sicherstellung einer flächendeckenden und bedarfsgerechten hausärztlichen Versorgung stellt
zunehmend eine Herausforderung dar. Die Analyse von Prioritäten und Einflussfaktoren hinsichtlich des Niederlassungsverhaltens ist
daher von hoher Bedeutung für eine bedarfsgerechte Versorgungskoordination. In dieser Arbeit wurden Einflussfaktoren auf die
Standortwahl von Stadt- und Landärzten in Niedersachsen analysiert und bewertet. Ziel dieser Arbeit war es, bevorzugte
Standortfaktoren aus ärztlicher Perspektive zu ermitteln, um neue Steuerungsansätze für die Sicherstellung der Versorgung zu
identifizieren.
Methoden Der erste Studienabschnitt zu den Prioritäten der Einflussfaktoren auf die Standortwahl (PrEf) zielte auf die
Erhebung der Relevanz von Standortfaktoren mithilfe des Analytic Hierarchy Process (AHP) in persönlichen Interviews ab. Im
Anschluss wurde in Niedersachsen eine Querschnittserhebung der Einflussfaktoren auf die Standortwahl (QuESt) durchgeführt und
mittels logistischer Regressionen die Präferenzen für die Standortwahl von Stadt- und Landärzten ermittelt.
Ergebnisse Im ersten Studienabschnitt PrEf konnten 10 AHP-Befragungen einbezogen werden. Das „Umfeld für die Familie“
erreichte mit einem globalen Gewicht von 32,4 % (SD = 19,4) die höchste Priorität in PrEf, gefolgt von „finanziellen
Rahmenbedingungen“ (19,0 %, SD = 13,0) und „beruflichen Verpflichtungen“ (13,4 %, SD = 9,0). Dabei unterschieden sich in QuESt
(n = 197) die Prioritäten zwischen Land- und Stadtärzten bei „finanziellen Rahmenbedingungen“, die von Landärzten mit 0,84 Punkten
(p ≤ 0,05) wichtiger bewertet wurden.
Diskussion und Schlussfolgerung Entscheidend für die Niederlassung ist das „Umfeld für die Familie“, das in ländlichen
Regionen häufig nicht den Wünschen entspricht. Die „finanziellen Rahmenbedingungen“ sind an zweiter Stelle und für Landärzte
besonders wichtig. Die Politik, Kassenärztliche Vereinigungen und Kommunen sollten sich in Zukunft auf diese Steuerungsfaktoren
fokussieren.
SVPV: a structural variant prediction viewer for paired-end sequencing datasets
Authors: Munro Jacob E , Dunwoodie Sally L , Giannoulatou Eleni 
Published: February 2017

Abstract

Motivation
A wide range of algorithms exist for the prediction of structural variants (SVs) from paired-end whole genome sequencing (WGS) alignments. It is essential for the purpose of quality control to be able to visualize, compare and contrast the data underlying the predictions across multiple different algorithms.

Results
We provide the structural variant prediction viewer, a tool which presents a visual summary of the most relevant features for SV prediction from WGS data. SV calls from multiple prediction algorithms may be visualized together, along with annotation of population allele frequencies from reference SV datasets. Gene annotations may also be included. The application is capable of running in a Graphical User Interface (GUI) mode for visualizing SVs one by one, or in batch mode for processing many SVs serially.

Availability and Implementation
SVPV is available at GitHub (https://github.com/VCCRI/SVPV/).

Supplementary information
Supplementary data are available at Bioinformatics online.
Are informed policies in place to promote safe and usable EHRs? A cross-industry comparison
Authors: Savage Erica L , Fairbanks Rollin J , Ratwani Raj M 
Published: February 2017

AbstractObjective: Despite federal policies put in place by the Office of the National Coordinator (ONC) to promote safe and usable electronic health record (EHR) products, the usability of EHRs continues to frustrate providers and have patient safety implications. This study sought to compare government policies on usability and safety, and methods of examining compliance to those policies, across 3 federal agencies: the ONC and EHRs, the Federal Aviation Administration (FAA) and avionics, and the Food and Drug Administration (FDA) and medical devices. Our goal was to identify whether differences in policies exist and, if they do exist, how policies and enforcement mechanisms from other industries might be applied to optimize EHR usability.Method: We performed a qualitative study using publicly available governing documents to examine similarities and differences in usability and safety policies across agencies.Results: The policy review and analysis revealed several consistencies within each agency’s usability policies. Critical differences emerged in the usability standards and policy enforcement mechanisms utilized by the 3 agencies. The FAA and FDA look at evidence of usability processes and are more prescriptive when it comes to testing final products as compared to the ONC, which relies on attestation and is less prescriptive.Discussion: A comparison of usability policies across industries illustrates key differences between the ONC and other federal agencies. These differences could be contributing to the usability challenges associated with EHRs.Conclusion: Our analysis highlights important areas of usability and safety policy from other industries that can better inform ONC policies on EHRs.
Cubital Tunnel Syndrome: Incidence and Demographics in a National Administrative Database
Authors: Osei Daniel A. , Groves Andrew P. , Bommarito Kerry , Ray Wilson Z. 
Published: February 2017

Abstract

BACKGROUND: Compressive neuropathy of the ulnar nerve at the elbow, or cubital tunnel syndrome (CuTS), is the second most common entrapment neuropathy of the upper extremity after carpal tunnel syndrome. While several studies have reported risk factors and outcomes for select populations (mostly surgical), it is difficult to interpret these data without an accurate measure of CuTS disease burden in the general population.

OBJECTIVE: To estimate the incidence of CuTS among US health plan enrollees, using a large administrative health care claims database comprised of individuals from all 50 states.

METHODS: An administrative database of commercial insurance beneficiaries was queried for diagnosis and treatment of CuTS over a 6-yr period. We examined subsequent claims to determine frequency of subsequent surgical treatment. Descriptive statistics were used to determine the association of incident cases and surgical treatment with age and gender.

RESULTS: The estimated adjusted incidence rate of CuTS is 30.0 per 100 000 person-years. Of the 53 401 identified new cases within this cohort from 2006 to 2012, 41.3% were treated surgically. Incident cases were identified more frequently in men than in women (31.2 vs 28.8 cases per 100 000 person-years), though we observed more cases in women than in men below 50 yr of age (20.9 vs 19.5 cases per 100 000 person-years). Overall, incident cases increase with age in both men and women. In addition to incident cases being more common with increasing age, the percentage of cases treated surgically also increases with age (surgery in 34.4% of cases in the 18-30 yr group vs 48.8% of cases in the 60-65 yr group).

CONCLUSION: The purpose of this study was to estimate the incidence of CuTS among US health plan enrollees. This is the largest published study on the incidence of CuTS, and the first to look at a US population. The overall adjusted incidence of CuTS was 30.0 per 100 000 person-years. Of patients who developed CuTS, 41.3% were treated surgically during the study period. Our results corroborate previously reported literature suggesting incidence increases significantly with age, with a slightly higher incidence in males. A high percentage of people who were diagnosed with CuTS and ended up receiving surgical intervention (41.3%) were older males. These results may aid practitioners in providing some basic prognostic information to patients who develop CuTS.
Correlation of Subjective Hospital Compare Metrics With Objective Outcomes of Cranial Neurosurgical Procedures in New York State
Authors: Bekelis Kimon , Missios Symeon , Coy Shannon , Rahmani Redi , MacKenzie Todd A. , Asher Anthony L. 
Published: February 2017

AbstractBACKGROUND:Public reporting is at the forefront of health care reform.OBJECTIVE:To investigate whether patient satisfaction as expressed in a public reporting platform correlates with objective outcomes for cranial neurosurgery patients.METHODS:We performed a cohort study involving patients undergoing cranial neurosurgery from 2009 to 2013 who were registered in the Statewide Planning and Research Cooperative System database. This cohort was merged with the corresponding data from the Centers for Medicare and Medicaid Services Hospital Compare website. The association of patient satisfaction metrics with outcomes was examined with the use of a propensity-adjusted regression model.RESULTS:Overall, 19 591 patients underwent cranial neurosurgery during the study. Using a propensity-adjusted multivariable regression analysis, we demonstrated that hospitals with a greater percentage of patient-assigned “high” scores had decreased mortality (OR, 0.60; 95% CI, 0.53-0.67), rate of discharge to rehabilitation (OR, 0.93; 95% CI, 0.88-0.98), length of stay (adjusted difference, –1.29; 95% CI, –1.46 to –1.13), and hospitalization charges (adjusted difference, –23%; 95% CI, –36% to –9%) after cranial neurosurgery. Similar associations were identified for hospitals with a higher percentage of patients, who would recommend these institutions to others.CONCLUSION:In a Centers for Medicare and Medicaid Services Hospital Compare–Statewide Planning and Research Cooperative System merged dataset, we observed an association of higher performance in patient satisfaction measures with decreased mortality, rate of discharge to rehabilitation, hospitalization charges, and length of stay.
Lumbar Spinal Stenosis Associated With Degenerative Lumbar Spondylolisthesis: A Systematic Review and Meta-analysis of Secondary Fusion Rates Following Open vs Minimally Invasive Decompression
Authors: Schöller Karsten , Alimi Marjan , Cong Guang-Ting , Christos Paul , Härtl Roger 
Published: February 2017

Abstract

BACKGROUND: Decompression without fusion is a treatment option in patients with lumbar spinal stenosis (LSS) associated with stable low-grade degenerative spondylolisthesis (DS). A minimally invasive unilateral laminotomy (MIL) for “over the top” decompression might be a less destabilizing alternative to traditional open laminectomy (OL).

OBJECTIVE: To review secondary fusion rates after open vs minimally invasive decompression surgery.

METHODS: We performed a literature search in Pubmed/MEDLINE using the keywords “lumbar spondylolisthesis” and “decompression surgery.” All studies that separately reported the outcome of patients with LSS+DS that were treated by OL or MIL (transmuscular or subperiosteal route) were included in our systematic review and meta-analysis. The primary end point was secondary fusion rate. Secondary end points were total reoperation rate, postoperative progression of listhetic slip, and patient satisfaction.

RESULTS: We identified 37 studies (19 with OL, 18 with MIL), with a total of 1156 patients, that were published between 1983 and 2015. The studies’ evidence was mostly level 3 or 4. Secondary fusion rates were 12.8% after OL and 3.3% after MIL; the total reoperation rates were 16.3% after OL and 5.8% after MIL. In the OL cohort, 72% of the studies reported a slip progression compared to 0% in the MIL cohort, respectively. After OL, satisfactory outcome was 62.7% compared to 76% after MIL.

CONCLUSION: In patients with LSS and DS, minimally invasive decompression is associated with lower reoperation and fusion rates, less slip progression, and greater patient satisfaction than open surgery.
Long-term Outcome After Multiple Burr Hole Surgery in Children With Moyamoya Angiopathy: A Single-Center Experience in 108 Hemispheres
Authors: Blauwblomme Thomas , Mathon Bertrand , Naggara Olivier , Kossorotoff Manoelle , Bourgeois Marie , Puget Stéphanie , Meyer Philippe , Brousse Valentine , de Montalembert Marianne , Brunelle Francis , Zerah Michel , Sainte-Rose Christian 
Published: February 2017

Abstract

BACKGROUND: Multiple burr hole (MBH) surgery is a simple, safe, and effective indirect technique of revascularization in moyamoya angiopathy (MM). However, it is not yet recognized as a first-line treatment.

OBJECTIVE: To assess the long-term outcome and perioperative complications in a large single-center cohort of children with MM who underwent burr hole surgery.

METHODS: This study is a retrospective analysis of children who underwent surgery for MM in a national reference center for pediatric stroke between 1999 and 2015. Sixty-four children (108 hemispheres, median age 7 years) were consecutively treated. The indication for revascularization was previous stroke or transient ischemic attack (TIA) or rapidly progressive disease on brain magnetic resonance imaging (MRI) and digital subtraction angiography. Children were followed with clinical examinations, telephone interviews, and MRI with any clinical recurrence of stroke or TIA used as the primary endpoint. Surgical mortality and morbidity were documented.

RESULTS: Sixty-four patients were operated (bilateral MBH n = 39, unilateral procedure n = 25). At a mean follow-up of 4.2 years and 270.6 patient years, 89.1% of patients had not suffered any recurrent stroke or TIA. A second surgery was required in 5 cases after unilateral revascularization, and in 3 cases after bilateral MBH. Mortality associated with the procedure was 0. Postoperative Matsushima angiographic grading was the only predictive factor of ischemic recurrence (P = .036).

CONCLUSION: In pediatric MM, MBH compares favorably to other indirect or direct revascularization techniques in children in the prevention of stroke or TIA.
Clinical and Mucosal Immune Correlates of HIV-1 Semen Levels in Antiretroviral-Naive Men
Authors: Osborne Brendan J. W. , Marsh Angie K. , Huibner Sanja , Shahabi Kamnoosh , Liu Cindy , Contente Tania , Nagelkerke Nico J. D. , Kovacs Colin , Benko Erika , Price Lance , MacDonald Kelly S. , Kaul Rupert 
Published: February 2017

Abstract

Background
This study was done to characterize parameters associated with semen human immunodeficiency virus (HIV)-1 ribonucleic acid (RNA) viral load (VL) variability in HIV-infected, therapy-naive men.

Methods
Paired blood and semen samples were collected from 30 HIV-infected, therapy-naive men who have sex with men, and 13 participants were observed longitudinally for up to 1 year. Human immunodeficiency virus RNA, bacterial load by 16S RNA, herpesvirus (Epstein-Barr virus and cytomegalovirus [CMV]) shedding, and semen cytokines/chemokines were quantified, and semen T-cell subsets were assessed by multiparameter flow cytometry.

Results
Semen HIV RNA was detected at 93% of visits, with &gt;50% of men shedding high levels of virus (defined as &gt;5000 copies/mL). In the baseline cross-sectional analysis, an increased semen HIV VL correlated with local CMV reactivation, the semen bacterial load, and semen inflammatory cytokines, particularly interleukin (IL)-8. T cells in semen were more activated than blood, and there was an increased frequency of Th17 cells and γδ-T-cells. Subsequent prospective analysis demonstrated striking interindividual variability in HIV and CMV shedding patterns, and only semen IL-8 levels and the blood VL were independently associated with semen HIV levels.

Conclusions
Several clinical and immune parameters were associated with increased HIV semen levels in antiretroviral therapy-naive men, with induction of local proinflammatory cytokines potentially acting as a common pathway.