bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fiber-optic drug delivery strategy for synergistic cancer photothermal-chemotherapy
Authors: Zhang Yongkang , Zheng Jie , Jin Fangzhou , Xiao Jie , Lan Ni , Xu Zhiyuan , Yue Xu , Li Zesen , Li Chengzhi , Cao Donglin , Wang Yifei , Zhong Wenbin , Ran Yang , Guan Bai-Ou 
Published: September 2024

AbstractChemotherapy is one of the conventional treatments for cancer in clinical practice. However, poor delivery efficiency, systemic toxicity, and the lack of pharmacokinetic monitoring during treatment are the critical limitations of current chemotherapy. Herein, we reported a brand-new antitumor drug delivery strategy that harnesses an optical fiber endoscopically therapeutic probe. The fiber probe carries photosensitizers in the fiber core and antitumor agents on the fiber surface mediated by a temperature-responsive hydrogel film, giving rise to an activable photothermal-chemotherapy that orchestrates the localized hyperthermia and thermal-stimuli drug release to the tumor lesion. Furthermore, the dynamical drug release and in-situ temperature can be real-time supervised through the built-in fiber sensors, including the reflective Mach–Zehnder interferometer and fiber Bragg grating, to visualize the therapy process and thus improve the safety of treatment. Compared with conventional methods, the fiber-optic drug delivery can adequately take advantage of the chemotherapeutics through collaboratively recruiting the photoheating-mediated enhanced permeability and the hydrogel particle-assisted high drug retention, shedding new light on a “central-to-peripheral” drug pervasion and retention mechanism to destroy tumors completely. The fiber-optic chemotherapy strategy incorporates precise drug delivery, accurate controllability of drug release, high drug permeability and retention in tumor, low off-target rate, and real-time drug release and temperature feedback, performing a straightforward and precise photothermal-chemotherapy pathway. More than that, the proposed strategy holds tremendous promise to provide a revolutionized on-demand drug delivery platform for the highly efficient evaluation and screening of antitumor pharmaceuticals.
Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice
Authors: King Ashleigh , Reichl Pia I. , Metson Jean S. , Parker Robert , Munro Daniella , Oliveira Catarina , Sommerova Lucia , Becker Jordan R. , Biggs Daniel , Preece Chris , Davies Benjamin , Chapman J. Ross 
Published: September 2024

Abstract
Tumor suppressor p53-binding protein 1 (53BP1) regulates DNA end joining in lymphocytes, diversifying immune antigen receptors. This involves nucleosome-bound 53BP1 at DNA double-stranded breaks (DSBs) recruiting Rap1-interacting factor 1 homolog (RIF1) and shieldin, a poorly understood DNA-binding complex. The 53BP1–RIF1–shieldin axis is pathological in BRCA1-mutated cancers, blocking homologous recombination (HR) and driving illegitimate nonhomologous end joining (NHEJ). However, how this axis regulates DNA end joining and HR suppression remains unresolved. We investigated shieldin and its interplay with the Ctc1–Stn1–Ten1 (CST) complex, which was recently implicated downstream of 53BP1. Immunophenotypically, mice lacking shieldin or CST are equivalent, with class-switch recombination coreliant on both complexes. Ataxia-telangiectasia mutated kinase-dependent DNA damage signaling underpins this cooperation, inducing physical interactions between these complexes that reveal shieldin as a DSB-responsive CST adaptor. Furthermore, DNA polymerase ζ functions downstream of shieldin, establishing DNA fill-in synthesis as the physiological function of shieldin–CST. Lastly, we demonstrate that 53BP1 suppresses HR and promotes NHEJ in BRCA1-deficient mice and cells independently of shieldin. These findings showcase the versatility of the 53BP1 pathway, achieved through the collaboration of chromatin-bound 53BP1 complexes and DNA end-processing effector proteins.
Implementation of a Speech-Language Pathologist–Led Tracheostomy Team in a Level 1 Trauma Hospital
Authors: Silveira Rachael M. , López Nicole Yordán , Luque Ilko , Puebla Brittany , Wilson Whitney , Morejón Orlando 
Published: September 2024

Purpose:
Cited benefits of a tracheostomy team include reduction in adverse events, length of stay (LOS), and hospital costs. However, there is a lack of research regarding the implementation and benefits of a speech-language pathologist (SLP)-led tracheostomy team. Our goal is to evaluate the effect of an SLP-led tracheostomy team in trauma patients.

Method:

An SLP-led tracheostomy team was implemented in the trauma service at Hospital Corporations of America Florida Kendall Hospital as a quality improvement project. Data were collected from January 1, 2021, to August 31, 2022. Patients were divided into a pre-tracheostomy team cohort, which served as a historical control, and a post-tracheostomy team cohort. SLP consult, days to SLP consult, Passy-Muir Valve (PMV) use, days to PMV, oral diet, days to start oral diet, downsizing the tracheostomy tube, days to downsize, decannulation, days to decannulation, and LOS were the outcome measures of interest. Pearson's chi-square and Mann–Whitney tests were used to evaluate for a significant difference (
p
< .05) between the pre-tracheostomy team cohort and the post-tracheostomy team cohort.

Results:

Ninety-one patients were included in the final analysis (36 pre-tracheostomy team cohort, 55 post-tracheostomy team cohort). Pre-tracheostomy team and post-tracheostomy team cohorts were grossly similar (
p
> .05) in age, sex, and primary admission diagnosis. We found an increase in SLP consultation (58.3%–89.1%,
p
< .001), PMV utilization (44.4%–67.3%,
p
= .031), and decannulation (8.3%–30.9%,
p
= .011). Days to SLP consult decreased when comparing pre-tracheostomy team to post-tracheostomy team cohorts from 6 to 2, respectively (
p
< .001).

Conclusions:
Our approach of placing the SLP in the leading role is novel. After implementation of an SLP-led tracheostomy team, we saw improved outcomes of tracheostomy patients in the trauma population. SLPs should be included as integral members and potential leaders of tracheostomy teams based on their experience and expertise in tracheostomized patient care.
AXES-2MRS: A new all-sky catalogue of extended X-ray galaxy groups
Authors: Khalil H. , Finoguenov A. , Tempel E. , Mamon G. A. 
Published: September 2024

Context. Understanding baryonic physics at the galaxy-group level is a prerequisite for cosmological studies of the large-scale structure. One poorly understood aspect of galaxy groups is related to the properties of their hot intragroup medium. The well-studied X-ray groups have strong cool cores by which they were selected, so expanding the selection of groups is currently an important avenue in uncovering the diversity within the galaxy group population.
Aims. We present a new all-sky catalogue of X-ray-detected groups (AXES-2MRS) based on the identification of large X-ray sources found in the ROSAT All-Sky Survey (RASS) with the Two Micron Redshift Survey (2MRS) Bayesian Group Catalogue. We studied the basic properties of these galaxy groups to gain insights into the effect of different group selections on the properties.
Methods. In addition to X-ray luminosity from shallow survey data of RASS, we obtained detailed X-ray properties of the groups by matching the AXES-2MRS catalogue to archival X-ray observations by XMM-Newton and complemented this by adding the published XMM-Newton results on galaxy clusters in our catalogue. We analysed temperature and density to the lowest overdensity accessible by the data, obtaining hydrostatic mass estimates at a uniform overdensity of 10 000 times the critical, M10 000, and comparing them to the velocity dispersions of the groups. We explored the relationship between X-ray and optical properties of AXES-2MRS groups through the σv−LX, σv−kT, kT−LX, σv−M, and c200−LX scaling relations.
Results. We find a large spread in the central mass ( M10 000), measured by XMM-Newton, to virial mass (M200), inferred by the velocity dispersion, ratios for galaxy groups. This can either indicate that large non-thermal pressure of galaxy groups affects our X-ray mass measurements or the effect of a diversity of halo concentrations on the X-ray properties of galaxy groups. Previous catalogues based on detecting the peak of the X-ray emission preferentially sample the high-concentration groups. In contrast, our new catalogue uncovered many low-concentration groups, completely revising our understanding of X-ray groups.
Toroidal modified Miller-Turner CME model in EUHFORIA: Validation and comparison with flux rope and spheromak
Authors: Maharana A. , Linan L. , Poedts S. , Magdalenić J. 
Published: September 2024

Context. Rising concerns about the impact of space-weather-related disruptions demand modelling and reliable forecasting of coronal mass ejection (CME) impacts.
Aims. In this study, we demonstrate the application of the modified Miller-Turner (mMT) model implemented within EUropean Heliospheric FORecasting Information Asset (EUHFORIA) in forecasting the geo-effectiveness of observed coronal mass ejection (CME) events in the heliosphere. Our goal is to develop a model that not only has a global geometry, in order to improve overall forecasting, but is also fast enough for operational space-weather forecasting.
Methods. We test the original full torus implementation and introduce a new three-fourths Torus version called the Horseshoe CME model. This new model has a more realistic CME geometry, and overcomes the inaccuracies of the full torus geometry. We constrain the torus geometrical and magnetic field parameters using observed signatures of the CMEs before, during, and after the eruption. We perform EUHFORIA simulations for two validation cases – the isolated CME event of 12 July 2012 and the CME–CME interaction event of 8–10 September 2014. We performed an assessment of the model’s capability to predict the most important Bz component using the advanced dynamic time-warping (DTW) technique.
Results. The Horseshoe model predictions of CME arrival time and geo-effectiveness for both validation events compare well with the observations and are weighed against the results obtained with the spheromak and FRi3D models, which were already available in EUHFORIA.
Conclusions. The runtime of the Horseshoe model simulations is close to that of the spheromak model, which is suitable for operational space weather forecasting. However, the capability of the magnetic field prediction at 1 AU of the Horseshoe model is close to that of the FRi3D model. In addition, we demonstrate that the Horseshoe CME model can be used for simulating successive CMEs in EUHFORIA, overcoming a limitation of the FRi3D model.
New results on the gamma-ray burst variability–luminosity relation
Authors: Guidorzi C. , Maccary R. , Tsvetkova A. , Kobayashi S. , Amati L. , Bazzanini L. , Bulla M. , Camisasca A. E. , Ferro L. , Frederiks D. , Frontera F. , Lysenko A. , Maistrello M. , Ridnaia A. , Svinkin D. , Ulanov M. 
Published: September 2024

Context. At the dawn of the gamma–ray burst (GRB) afterglow era, a Cepheid-like correlation was discovered between the time variability V and the isotropic-equivalent peak luminosity Liso of the prompt emission of about a dozen long GRBs with measured redshift available at that time. Soon afterwards, the correlation was confirmed in a sample of about 30 GRBs, even though it was affected by significant scatter. Unlike the minimum variability timescale (MVT), V measures the relative power of short-to-intermediate timescales.
Aims. We aim to test the correlation using about 200 long GRBs with spectroscopically measured redshift, detected by Swift, Fermi, and Konus/WIND, for which both observables can be accurately estimated.
Methods. The variability for all selected GRBs was calculated according to the original definition using the 64 ms background-subtracted light curves of Swift/BAT (Fermi/GBM) in the 15–150 (8–900) keV energy passband. Peak luminosities were either taken from the literature or derived from modelling broad-band spectra acquired with either Konus/WIND or Fermi/GBM.
Results.The statistical significance of the correlation has weakened to ≲2%, mostly due to the appearance of a number of smooth and luminous GRBs that are characterised by a relatively small V. At odds with most long GRBs, three out of four long-duration merger candidates have high V and low Liso.
Conclusions. The luminosity is more tightly connected with shortest timescales measured by MVT than the short to intermediate timescales measured by V. We discuss the implications for internal dissipation models and the role of the e± photosphere. We identified a few smooth GRBs with a single broad pulse and low V that might have an external shock origin, in contrast with most GRBs. The combination of high variability (V ≳ 0.1), low luminosity Liso ≲ 1051 erg s−1, and short MVT (≲0.1 s) could be a good indicator for a compact binary merger origin.
Fat Distribution and its Correlation with Insulin Resistance,
Androgen Markers, and Proinflammatory Cytokines in Polycystic Ovary
Syndrome
Authors: de Melo Cavalcante Rebeca Bandeira , Leão Lenora Maria Camarate Silveira Martins , Tavares Ana Beatriz Winter , Lopes Karynne Grutter , Kraemer-Aguiar Luiz Guilherme 
Published: September 2024

AbstractThe high cardiometabolic risk associated with polycystic ovary syndrome (PCOS)
may be linked to central fat accumulation. This study compared fat distribution
between women with PCOS and controls matched by body mass index. It also sought
to determine if insulin resistance (IR), androgens, or inflammatory markers
correlate with body composition parameters in PCOS patients. In total,
thirty-five women with PCOS and 37 controls, aged 18–40 years, were included.
Hormonal/metabolic profiles, inflammatory biomarkers [tumor necrosis
factor-alpha (TNF-α and interleukin-6 (IL-6)], anthropometry (waist
circumference, waist-to-hip ratio, lipid accumulation product [LAP], visceral
adiposity index [VAI]), and body composition assessed through dual-energy X-ray
absorptiometry were assessed. The PCOS group exhibited significantly higher
androgen levels and markers of IR. However, levels of TNF-α and IL-6 were
comparable between the groups. Despite having similar total body fat mass (FM),
the PCOS group had excessive central fat, including increased truncal FM and
visceral adipose tissue (VAT). In PCOS, androgens were not associated with body
fat or its distribution. IL-6 was positively correlated with total and truncal
FM, while insulinemia and the homeostatic model assessment for IR were
positively associated with VAT, as well as with total and truncal FM. Although
anthropometric measurements and indices were positively associated with
DXA-derived central FM parameters, our data suggest that LAP is the most
effective tool for assessing central fat deposition and metabolic dysfunction in
the PCOS patients studied herein. Furthermore, in this population, IR, rather
than androgens or proinflammatory cytokines, is more closely associated with
abdominal obesity.
Clinical Presentation, Surgical Treatment, and Outcome of Traumatic Patellar Luxation in 11 Dogs and 5 Cats: A Single-Centre Retrospective Study between 2011 and 2022
Authors: Boullenger Julien , Beyer Clémentine , Sériot Paul , Griffeuille Emilien , Gibert Sophie , Dunié-Mérigot Antoine 
Published: September 2024

Abstract
Objective Patellar luxation (PL) is commonly diagnosed in dogs and cats; however, a traumatic cause is poorly reported in the literature. The aim of this study was to report the clinical presentation, surgical treatment, and outcome in dogs and cats surgically treated for traumatic PL.
Study Design This is a retrospective study. Medical records of dogs and cats operated for traumatic PL were reviewed. Short- and long-term follow-ups were assessed with medical records and telephone interviews with owners and referring veterinarians. Data on signalment, lameness, PL characteristics, surgery, complications, and outcome were recorded.
Results Eleven dogs and 5 cats were included. Both species had a median lameness grade of 4/5 and a median PL grade of 3/4. PL was medial in most cases (13/16). Joint capsule lesions were identified in 15 cases, 4 cases had trochlear ridge cartilage damage. All cases had a capsular imbrication, 12 cases had a fabello-patellar suture (FPS). Mean long-term follow-up time was 70.8 ± 42.5 months in 9 dogs and 4 cats. Ten cases out of 13 had no lameness at the 2-month follow-up, and 11/13 cases had no long-term lameness. Eleven cases out of 13 had no PL at the 2-month follow-up. No long-term PL was reported by owners. Complications were mild in 5 cases, moderate in 1, severe in 3. Functional outcome was full in 10 cases and acceptable in 3.
Conclusion Soft tissue techniques and FPS were effective in the surgical treatment of traumatic PL in dogs and cats, resulting in acceptable to full long-term function in all cases, with limited severe complications.
Visible/near-infrared luminescence and concentration effects of Pr3+-doped Sr2Al2GeO7 downconversion phosphors
Authors: Shen Tiantian , Zhao Shanshan , Su An , Liu Haisheng , Chen Fayi , Li Benchun , Han Xinxin , Yu Dechao , Zhang Dawei 
Published: September 2024

The Pr3+ ion has been widely doped into various materials as a red and near-infrared (NIR) emitting center for applications in lighting and solar spectrum downconversion. Herein, the preparation of a new library of Pr3+-doped Sr2Al2GeO7 phosphors was proved by powder x-ray diffraction patterns and Rietveld refinements and characterized by a scanning electron microscope with energy-dispersive x-ray spectrometry. The Sr2Al2GeO7:Pr3+ sample strongly absorbs blue photons over 420–500 nm and yields intense visible emissions with dominant peaks around 490 nm from the Pr3+ 3P0 → 3H4 transition, as well as robust NIR emission bands over 800–1200 nm. In addition to the typical transitions of 1D2 → 3F2 at 880 nm, 1G4 → 3H4 at 1000 nm, and 1D2 → 3F3,4 at 1070 nm, the distinguishable NIR emission at 929 nm was demonstrated from the 3P0 → 1G4 transition via static and dynamic spectroscopic analysis. Most interestingly, for the 3P0 blue-excited state, a considerably elevated concentration of about 10%Pr3+ was optimal for the visible/NIR emissions, in stark contrast to the diluted optimal 1%Pr3+ for the 1D2 state. The relevant cross-relaxation from the 3P0 and 1D2 states between Pr3+ was comprehensively treated by theoretical speculations and experimental results. Such concentrated Pr3+ blue activators would significantly facilitate the blue-to-NIR downconversion through a desired two-step sequential transition from the 3P0 initial state to the 1G4 intermediate level for quantum efficiency exceeding unity. The current results would consolidate the basis of concentrated Pr3+ donors to promote the novel Pr3+/Yb3+ codoping downconversion for greatly increasing Si solar cell efficiency.
Use of RSM desirability approach to optimize WEDM of mild steel
Authors: T Mohanraj , G Sakthivel , Pramanik A 
Published: September 2024

Abstract
Wire Electrical Discharge Machining (WEDM) is a non-traditional material removal process commonly used for precision machining of hard materials such as super alloys, ceramics, carbide, and composite materials. Optimization of process parameters is critical for improving machining efficiency and achieving the desired surface quality. Response Surface Methodology (RSM) systematically optimizes process parameters and investigates their impact on machining performance. WEDM control parameters such as pulse ON Time (TON) (50–60 μs), pulse OFF Time (TOFF) (25–34 μs), gap voltage (VG) (25–250 V), peak current (IP) (1–6 A), and dielectric flow rate (Df) (1–3 LPM) are optimized to reduce surface roughness (SR) and taper angle (TA) while increasing material removal rate (MRR) during the machining of Mild Steel. The optimal parameters are TON as 53 μs, TOFF as 28 μs, IP as 2.65 A, VG as 185 V, and Df as 1.5 LPM. The experimental findings are presented to demonstrate the usefulness of the proposed strategy in optimizing WEDM control parameters. The validation test was conducted under optimal conditions and the results were reported. The manufacturing industries can use RSM optimization in the manufacturing domain.
MicroMagnetic.jl: A Julia package for micromagnetic and atomistic simulations with GPU support
Authors: Wang 王 Weiwei 伟伟 , Lyu 吕 Boyao 伯尧 , Kong 孔 Lingyao 令尧 , Fangohr Hans , Du 杜 Haifeng 海峰 
Published: September 2024

Abstract
MicroMagnetic.jl is an open-source Julia package for micromagnetic and atomistic simulations. Using the features of the Julia programming language, MicroMagnetic.jl supports CPU and various GPU platforms, including NVIDIA, AMD, Intel, and Apple GPUs. Moreover, MicroMagnetic.jl supports Monte Carlo simulations for atomistic models and implements the nudged-elastic-band method for energy barrier computations. With built-in support for double and single precision modes and a design allowing easy extensibility to add new features, MicroMagnetic.jl provides a versatile toolset for researchers in micromagnetics and atomistic simulations.
Siegmund duality for physicists: a bridge between spatial and first-passage properties of continuous- and discrete-time stochastic processes
Authors: Guéneau Mathis , Touzo Léo 
Published: September 2024

Abstract
We consider a generic one-dimensional stochastic process x(t), or a random walk Xn
, which describes the position of a particle evolving inside an interval

[
a
,
b
]

, with absorbing walls located at a and b. In continuous time, x(t) is driven by some equilibrium process

θ

(
t
)

, while in discrete time, the jumps of Xn
follow a stationary process that obeys a time-reversal property. An important observable to characterize its behavior is the exit probability

E
b

(
x
,
t
)

, which is the probability for the particle to be absorbed first at the wall b, before or at time t, given its initial position x. In this paper we show that the derivation of this quantity can be tackled by studying a dual process y(t) very similar to x(t) but with hard walls at a and b. More precisely, we show that the quantity

E
b

(
x
,
t
)

for the process x(t) is equal to the probability

Φ
~

(
x
,
t

|

b
)

of finding the dual process inside the interval

[
a
,
x
]

at time t, with

y
(
0
)
=
b

. This is known as Siegmund duality in mathematics. Here we show that this duality applies to various processes that are of interest in physics, including models of active particles, diffusing diffusivity models, a large class of discrete- and continuous-time random walks, and even processes subjected to stochastic resetting. For all these cases, we provide an explicit construction of the dual process. We also give simple derivations of this identity both in the continuous and in the discrete time setting, as well as numerical tests for a large number of models of interest. Finally, we use simulations to show that the duality is also likely to hold for more complex processes, such as fractional Brownian motion.
PV power prediction based on SSA improved BP neural network
Authors: Zhou Weiping , Xiong Hongjun 
Published: September 2024

Abstract
With the increasing popularity of photovoltaic (PV) power generation, its power prediction has also become a research hotspot. In this paper, on the basis of previous research, a PV power prediction model based on SSA-BP is proposed. It can optimize the BP neural network prediction model by constructing the sparrow search algorithm. After simulation, the accuracy and practicability of the SSA-BP model proposed in this paper are verified.