bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adjusted indices of multiple deprivation to enable comparisons within and between constituent countries of the UK including an illustration using mortality rates
Authors: Abel Gary A , Barclay Matthew E , Payne Rupert A 
Published: November 2016

ObjectivesSocial determinants can have a major impact on health and as a consequence substantial inequalities are seen between and within countries. The study of inequalities between countries relies on having accurate and consistent measures of deprivation across the country borders. However, in the UK most socioeconomic deprivation measures are not comparable between countries. We give a method of adjusting the Indices of Multiple Deprivation (IMD) for use across the UK, describe the deprivation of each UK country, and show the problems introduced by naïvely using country-specific deprivation measures in a UK-wide analysis of mortality rates.Setting/participants42 148 geographic areas covering the population of the UK.Outcome measuresAdjusted IMD scores based on the income and employment domains of country-specific IMD scores, adjusting for the contribution of other domains. The mortality rate among people aged under 75 years standardised to the UK age structure was compared between country-specific and UK-adjusted IMD quintiles.ResultsOf the constituent countries of the UK, Northern Ireland was the most deprived with 37% of the population living in areas in the most deprived fifth of the UK, followed by Wales with 22% of the population living in the most deprived fifth of the UK. England and Scotland had similar levels of deprivation. Deprivation-specific mortality rates were similar in England and Wales. Northern Ireland had lower mortality rates than England for each deprivation group, with similar differences for each group. Scotland had higher mortality rates than England for each deprivation group, with larger differences for more deprived groups.ConclusionsAnalyses of between-country and within-country inequalities by socioeconomic position should use consistent measures; failing to use consistent measures may give misleading results. The published adjusted IMD scores we describe allow consistent analysis across the UK.
Chest compression fraction in ambulance while transporting patients with out-of-hospital cardiac arrest to the hospital in rural Taiwan
Authors: Hung Shih-Chang , Mou Ching-Yi , Hung Hung-Chang , Lin I-Hsiang , Lai Shih-Wei , Huang Jack YinChun 
Published: November 2016

IntroductionMaintaining the standard two-handed chest compression is difficult in high-speed ambulances in rural areas.MethodsA retrospective, video-based, observational study was conducted from June to September 2013 in Nantou, a rural county of central Taiwan, to evaluate the chest compression fraction in an ambulance carriage during the travel from the scene to the hospital. The chest compression fraction was calculated as the chest compression time period divided by the ambulance travelling time period; the one-handed and two-handed chest compression fractions were also calculated.ResultsDuring the 4-month study period, a total of 102 videos that were recorded in an ambulance carriage were reviewed, including 97 cases of manual chest compressions. When there was only one emergency medical technician (EMT) in the carriage, the combined chest compression fraction was 50.6±20.7%; when there were two EMTs, the fraction was 58.3±16.0% and the fraction was 58.3±21.0% in a three-EMT scenario (p=0.221). Moreover, in the carriage, EMTs usually performed one-handed chest compressions.ConclusionsThe chest compression fraction was low for patients with out-of-hospital cardiac arrest in a moving ambulance, irrespective of the number of providers. Reasons for this observation, as well as the effectiveness of the one-handed chest compression require further evaluation.
Generalized orbifold construction for conformal nets
Authors: Bischoff Marcel 
Published: November 2016

Let [Formula: see text] be a conformal net. We give the notion of a proper action of a finite hypergroup [Formula: see text] acting by vacuum preserving unital completely positive (so-called stochastic) maps on [Formula: see text] which generalizes the proper action of a finite group [Formula: see text]. Taking the fixed point under such an action gives a finite index subnet [Formula: see text] of [Formula: see text], which generalizes the [Formula: see text]-orbifold net. Conversely, we show that if [Formula: see text] is a finite inclusion of conformal nets, then [Formula: see text] is a generalized orbifold [Formula: see text] of the conformal net [Formula: see text] by a unique finite hypergroup [Formula: see text]. There is a Galois correspondence between intermediate nets [Formula: see text] and subhypergroups [Formula: see text] given by [Formula: see text]. In this case, the fixed point of [Formula: see text] is the generalized orbifold by the hypergroup of double cosets [Formula: see text].If [Formula: see text] is a finite index inclusion of completely rational nets, we show that the inclusion [Formula: see text] is conjugate to an intermediate subfactor of a Longo–Rehren inclusion. This implies that if [Formula: see text] is a holomorphic net, and [Formula: see text] acts properly on [Formula: see text], then there is a unitary fusion category [Formula: see text] which is a categorification of [Formula: see text] and [Formula: see text] is braided equivalent to the Drinfel’d center [Formula: see text]. More generally, if [Formula: see text] is a completely rational conformal net and [Formula: see text] acts properly on [Formula: see text], then there is a unitary fusion category [Formula: see text] extending [Formula: see text], such that [Formula: see text] is given by the double cosets of the fusion ring of [Formula: see text] by the Verlinde fusion ring of [Formula: see text] and [Formula: see text] is braided equivalent to the Müger centralizer of [Formula: see text] in the Drinfel’d center [Formula: see text].
Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing β-Catenin
Authors: Jin Yanli , Nie Danian , Li Juan , Du Xin , Lu Yuhong , Li Yangqiu , Liu Chang , Zhou Jingfeng , Pan Jingxuan 
Published: November 2016

Abstract
Purpose: Quiescent leukemia stem cells (LSC) are important resources of resistance and relapse in chronic myelogenous leukemia (CML). Thus, strategies eradicating CML LSCs are required for cure. In this study, we discovered that AXL tyrosine kinase was selectively overexpressed in primary CML CD34+ cells. However, the role of AXL and its ligand Gas6 secreted by stromal cells in the regulation of self-renewal capacity of LSCs has not been well investigated.
Experimental Design: The function of CML CD34+ cells was evaluated by flow cytometer, CFC/replating, long-term culture-initiating cells (LTC-IC), CML mouse model driven by human BCR-ABL gene and NOD-scid-IL2Rg−/− (NSI) mice.
Results: AXL was selectively overexpressed in primary CML CD34+ cells. AXL knockdown reduced the survival and self-renewal capacity of human CML CD34+ cells. Pharmacologic inhibition of AXL reduced the survival and self-renewal capacity of human CML LSCs in vitro and in long-term grafts in NSI mice. Human CML CD34+ cells conscripted bone marrow–derived stromal cells (BMDSC) and primary mesenchymal stem cells (MSC) to secrete Gas6 to form a paracrine loop that promoted self-renewal of LSCs. Suppression of AXL by shRNA and inhibitor prolonged survival of CML mice and reduced the growth of LSCs in mice. Gas6/AXL ligation stabilizes β-catenin in an AKT-dependent fashion in human CML CD34+ cells.
Conclusions: Our findings improve the understanding of LSC regulation and validate Gas6/AXL as a pair of therapeutic targets to eliminate CML LSCs. Clin Cancer Res; 23(11); 2842–55. ©2016 AACR.
Genomic Evolution after Chemoradiotherapy in Anal Squamous Cell Carcinoma
Authors: Mouw Kent W. , Cleary James M. , Reardon Brendan , Pike Jonathan , Braunstein Lior Z. , Kim Jaegil , Amin-Mansour Ali , Miao Diana , Damish Alexis , Chin Joanna , Ott Patrick A. , Fuchs Charles S. , Martin Neil E. , Getz Gad , Carter Scott , Mamon Harvey J. , Hornick Jason L. , Van Allen Eliezer M. , D'Andrea Alan D. 
Published: November 2016

Abstract
Purpose: Squamous cell carcinoma of the anal canal (ASCC) accounts for 2% to 4% of gastrointestinal malignancies in the United States and is increasing in incidence; however, genomic features of ASCC are incompletely characterized. Primary treatment of ASCC involves concurrent chemotherapy and radiation (CRT), but the mutational landscape of resistance to CRT is unknown. Here, we aim to compare mutational features of ASCC in the pre- and post-CRT setting.
Experimental Design: We perform whole-exome sequencing of primary (n = 31) and recurrent (n = 30) ASCCs and correlate findings with clinical data. We compare genomic features of matched pre- and post-CRT tumors to identify genomic features of CRT response. Finally, we investigate the mutational underpinnings of an extraordinary ASCC response to immunotherapy.
Results: We find that both primary and recurrent ASCC tumors harbor mutations in genes, such as PIK3CA and FBXW7, that are also mutated in other HPV-associated cancers. Overall mutational burden was not significantly different in pre- versus post-CRT tumors, and several examples of shared clonal driver mutations were identified. In two cases, clonally related pre- and post-CRT tumors harbored distinct oncogenic driver mutations in the same cancer gene (KRAS or FBXW7). A patient with recurrent disease achieved an exceptional response to anti-programmed death (PD-1) therapy, and genomic dissection revealed high mutational burden and predicted neoantigen load.
Conclusions: We perform comprehensive mutational analysis of ASCC and characterize mutational features associated with CRT. Although many primary and recurrent tumors share driver events, we identify several unique examples of clonal evolution in response to treatment. Clin Cancer Res; 23(12); 3214–22. ©2016 AACR.
Ventricular‐Vascular Coupling in Marfan and Non‐Marfan Aortopathies
Authors: Loeper Farina , Oosterhof Jantine , van den Dorpel Mark , van der Linde Denise , Lu Yaxin , Robertson Elizabeth , Hambly Brett , Jeremy Richmond 
Published: November 2016

Background
Marfan syndrome (MFS) and familial non–syndromal thoracic aortic aneurysm and dissection (ns‐TAAD) are genetic aortopathies causing aortic dilatation with increased aortic stiffness. Left ventricular (LV) contractility and ventricular‐vascular coupling index (VVI) were compared between MFS and ns‐TAAD and determinants of VVI were investigated.

Methods and Results

Patients with MFS (M 57, F 47) and ns‐TAAD (M 72, F 39) were studied by echocardiography and compared with controls (M 77, F 71). Aortic geometry, hemodynamics, LV work, LV contractility (end‐systolic elastance [E
es
]), and VVI were documented. Aortic sinuses were equally dilated in MFS (19.7±2.4) and ns‐TAAD (19.8±1.8) compared to controls (16.2±1.4 mm·m
−2
,
P
<0.001). Aortic stiffness index was increased in MFS (9.7±5.1) and ns‐TAAD (10.8±4.7) versus controls (5.4±2.0,
P
<0.01); LV stroke work was unchanged in MFS (436±74) compared to controls (435±60) but increased in ns‐TAAD (492±109 mJ·m
−2
P
<0.01). The LV E
es
was reduced in MFS (1.32±0.19) compared to controls (1.65±0.29 mm Hg·mL
−1
,
P
<0.01) but increased in ns‐TAAD (1.83±0.30,
P
<0.01) and VVI was abnormal in MFS (0.71±0.11) compared to controls (0.62±0.07,
P
<0.01) and ns‐TAAD (0.62±0.09). Treatment with β‐blockers was associated with partial normalization of VVI in MFS. A VVI ≥0.8 was associated with increased risk of death and heart failure in MFS.

Conclusions
Left ventricular contractility and ventricular‐vascular coupling are abnormal in MFS but preserved in ns‐TAAD, and are independent of aortic stiffness, consistent with intrinsic impairment of myocardial contractility in MFS.
Local Atmospheric Response to an Open-Ocean Polynya in a High-Resolution Climate Model
Authors: Weijer Wilbert , Veneziani Milena , Stössel Achim , Hecht Matthew W. , Jeffery Nicole , Jonko Alexandra , Hodos Travis , Wang Hailong 
Published: November 2016

Abstract
In this paper the atmospheric response to an open-ocean polynya in the Southern Ocean is studied by analyzing the results from an atmospheric and oceanic synoptic-scale resolving Community Earth System Model (CESM) simulation. While coarser-resolution versions of CESM generally do not produce open-ocean polynyas in the Southern Ocean, they do emerge and disappear on interannual time scales in the synoptic-scale simulation. This provides an ideal opportunity to study the polynya’s impact on the overlying and surrounding atmosphere. This has been pursued here by investigating the seasonal cycle of differences of surface and air-column variables between polynya and nonpolynya years. The results indicate significant local impacts on turbulent heat fluxes, precipitation, cloud characteristics, and radiative fluxes. In particular, it is found that clouds over polynyas are optically thicker and higher than clouds over sea ice during nonpolynya years. Although the lower albedo of polynyas significantly increases the net shortwave absorption, the enhanced cloud brightness tempers this increase by almost 50%. Also, in this model, enhanced longwave radiation emitted from the warmer surface of polynyas is balanced by stronger downwelling fluxes from the thicker cloud deck. Impacts are found to be sensitive to the synoptic wind direction. The strongest regional impacts are found when northeasterly winds cross the polynya and interact with katabatic winds. Surface air pressure anomalies over the polynya are only found to be significant when cold, dry air masses strike over the polynya (i.e., in the case of southerly winds).
Multilevel Cloud Structures over Svalbard
Authors: Dörnbrack Andreas , Gisinger Sonja , Pitts Michael C. , Poole Lamont R. , Maturilli Marion 
Published: November 2016

Abstract
The presented picture of the month is a superposition of spaceborne lidar observations and high-resolution temperature fields of the ECMWF Integrated Forecast System (IFS). It displays complex tropospheric and stratospheric clouds in the Arctic winter of 2015/16. Near the end of December 2015, the unusual northeastward propagation of warm and humid subtropical air masses as far north as 80°N lifted the tropopause by more than 3 km in 24 h and cooled the stratosphere on a large scale. A widespread formation of thick cirrus clouds near the tropopause and of synoptic-scale polar stratospheric clouds (PSCs) occurred as the temperature dropped below the thresholds for the existence of cloud particles. Additionally, mountain waves were excited by the strong flow at the western edge of the ridge across Svalbard, leading to the formation of mesoscale ice PSCs. The most recent IFS cycle using a horizontal resolution of 8 km globally reproduces the large-scale and mesoscale flow features and leads to a remarkable agreement with the wave structure revealed by the spaceborne observations.
Humeral Retrotorsion and Glenohumeral Motion in Youth Baseball Players Compared With Age-Matched Nonthrowing Athletes
Authors: Greenberg Elliot M. , Lawrence J. Todd R. , Fernandez-Fernandez Alicia , McClure Philip 
Published: November 2016

Background: Baseball players exhibit a more posteriorly oriented humeral head in their throwing arm. This is termed humeral retrotorsion (HRT) and likely represents a response to the stress of throwing. This adaptation is thought to occur while the athlete is skeletally immature, however currently there is limited research detailing how throwing activity in younger players influences the development of HRT. In addition, it is presently unclear how this changing osseous orientation may influence shoulder motion within young athletes. Purpose: To determine the influence of throwing activity and age on the development of side-to-side asymmetry in HRT and shoulder range of motion (ROM). Study Design: Cross-sectional study; Level of evidence, 3. Methods: Healthy athletes (age range, 8-14 years) were categorized into 2 groups based upon sports participation; throwers (n = 85) and nonthrowers (n = 68). Bilateral measurements of HRT, shoulder external rotation (ER), internal rotation (IR), and total range of motion (TROM) at 90° were performed using diagnostic ultrasound and a digital inclinometer. Side-to-side asymmetry (dominant minus nondominant side) in HRT and in shoulder ER, IR, and TROM were assessed. Statistical analysis was performed with 2-way analysis of variance and Pearson correlation coefficients. Results: Throwers demonstrated a larger degree of HRT on the dominant side, resulting in greater asymmetry compared with nonthrowers (8.7° vs 4.8°). Throwers demonstrated a gain of ER (5.1°), a loss of IR (6.0°), and no change in TROM when compared with the nondominant shoulder. Pairwise comparisons identified altered HRT and shoulder ROM in all age groups, including the youngest throwers (age range, 8-10.5 years). A positive correlation existed between HRT and ER ROM that was stronger in nonthrowers ( r = 0.63) than in throwers ( r = 0.23), while a negative correlation existed with IR that was stronger in throwers ( r = −0.40) than in nonthrowers ( r = −0.27). Conclusion: Throwing activity causes adaptive changes in HRT and shoulder ROM in youth baseball players at an early age. Other factors in addition to HRT influence shoulder motion within this population.
Parents’ Acute Illnesses, Hospitalizations, and Medication Changes During the Difficult First Year After Infant or Child NICU/PICU Death
Authors: Brooten Dorothy , Youngblut JoAnne M. , Caicedo Carmen , del Moral Teresa , Cantwell G. Patricia , Totapally Balagangadhar 
Published: November 2016

Background and Objectives: Infant/child death is described as a most stressful life event; however, there are few reports of effects on parent physical health during the first year after the death. The study’s purpose is to examine the patterns of parent acute illnesses, hospitalizations, and medication changes over 1 to 13 months after neonatal intensive care unit (NICU) or pediatric intensive care unit (PICU) infant/child death in 3 racial/ethnic groups. Methods: Secondary analyses were conducted with longitudinal data on parent health and functioning 1 to 13 months after infant/child NICU/PICU death. Parents (176 mothers, 73 fathers; 44% Hispanic, 35% black non-Hispanic, and 21% white non-Hispanic) of deceased infants/children were recruited from 4 children’s hospitals and state death records. Inclusion criteria—parents understood English or Spanish and had a deceased neonate/child ≤ 18. Exclusion criteria —deceased newborn from multiple gestation pregnancy, child in foster care, child’s injury due to suspected abuse, or parent death in illness/injury event. Parents reported numbers and types of acute illnesses, hospitalizations, and medication changes 1 to 13 months postdeath. Results: Parents’ acute illnesses, hospitalizations, and medication changes were greatest between months 1 and 6, with relative quiescence in months 7 to 10, and an increase in months 11 to 13. Mothers (aged 32 ± 7.8 years) reported 300 acute illnesses (primarily colds/flu, headaches, anxiety/depression, and infections) and 89 hospitalizations (primarily infections, chest pain, and gastrointestinal problems). Fathers (aged 37 ± 8.8 years) reported 104 acute illnesses (colds/flu and headaches) and 9 hospitalizations. Conclusion: After infant/child NICU/PICU death, mothers had greater morbidity than fathers, with no significant differences by race/ethnicity. Parents’ health needs to be monitored in months 1 to 6 and months 11 to 13, and interventions targeted to parents in these months.
Peginterferon beta-1a reduces disability worsening in relapsing–remitting multiple sclerosis: 2-year results from ADVANCE
Authors: Newsome Scott D. , Kieseier Bernd C. , Liu Shifang , You Xiaojun , Kinter Elizabeth , Hung Serena , Sperling Bjoern 
Published: November 2016

Background: In the pivotal phase III 2-year ADVANCE study, subcutaneous peginterferon beta-1a 125 mcg every 2 weeks demonstrated significant improvements in clinical outcomes, including disability endpoints, in patients with relapsing–remitting multiple sclerosis (RRMS). Here, we aim to further evaluate disability data from ADVANCE, and explore associations between confirmed disability progression (CDP), functional status, and health-related quality of life (HRQoL). Methods: In total, 1512 patients were randomized to placebo or peginterferon beta-1a 125 mcg every 2 or 4 weeks. After 1 year, patients on placebo were re-randomized to peginterferon beta-1a every 2 or 4 weeks. CDP was defined as ⩾1.0 point increase from a baseline Expanded Disability Status Scale (EDSS) score ⩾ 1.0, or ⩾1.5-point increase from baseline 0, confirmed 12 or 24 weeks after onset. Results: Peginterferon beta-1a every 2 weeks significantly reduced risk of 12- and 24-week CDP at 1 year compared with placebo (12-week CDP: 6.8% versus 10.5%, p = 0.038; 24-week CDP: 4% versus 8.4%, p = 0.0069, peginterferon beta-1a every 2 weeks versus placebo, respectively). Benefits were maintained over 2 years (11.2% and 7.7%, peginterferon beta-1a every 2 weeks in 12- and 24-week CDP, respectively). Approximately 90% of patients with 24-week CDP had simultaneous worsening by ⩾1 point in at least one functional system score, most commonly pyramidal. Displaying a 24-week CDP was associated with worse scores on the Multiple Sclerosis Functional Composite (MSFC) scale and several HRQoL instruments; the impact of CDP was attenuated by treatment with peginterferon beta-1a every 2 weeks. Conclusions: Peginterferon beta-1a has the potential to prevent/delay worsening of disability in patients with relapsing–remitting multiple sclerosis. Furthermore, improved benefits in disability status with peginterferon beta-1a were also associated with improved functional status and HRQoL [ ClinicalTrials.gov identifier: NCT00906399].
Nodular regenerative hyperplasia rarely leads to liver transplantation: A 20‐year cohort study in all Dutch liver transplant units
Authors: Meijer Berrie , Simsek Melek , Blokzijl Hans , de Man Robert A , Coenraad Minneke J , Dijkstra Gerard , van Nieuwkerk Carin MJ , Mulder Chris JJ , de Boer Nanne KH 
Published: November 2016

BackgroundNodular regenerative hyperplasia is an uncommon liver condition associated with several autoimmune disorders and drugs. The clinical symptoms of nodular regenerative hyperplasia vary from asymptomatic to severe complications of portal hypertension (nodular regenerative hyperplasia‐syndrome).ObjectiveThe purpose of this study was to identify the prognosis and optimal management, as well as the role of liver transplantation, in nodular regenerative hyperplasia.MethodsThe pathology databases of all three Dutch liver transplant units were retrospectively scrutinised for explanted livers diagnosed with nodular regenerative hyperplasia or without clear diagnosis. Pre‐ and post‐transplantation clinical, biochemical, radiological and histological information was obtained from electronic and paper records.ResultsIn total, 1886 patients received a liver transplant. In 255 patients, nodular regenerative hyperplasia could not be excluded. After detailed chart review, the native livers of 11 patients (0.6%) (82% male, median age: 44 years) displayed nodular regenerative hyperplasia. Seven patients (64%) had underlying disorders or drug exposure which possibly caused nodular regenerative hyperplasia. Laboratory and imaging abnormalities were present in all patients but did not contribute to the diagnosis of nodular regenerative hyperplasia. Five‐year survival was 73% (median follow‐up: four years, range: 2–248 months).ConclusionNodular regenerative hyperplasia is a rare finding in patients, predominantly young males, transplanted for end‐stage liver disease with unknown aetiology. Nonetheless, liver transplantation may have an important role in end‐stage nodular regenerative hyperplasia‐syndrome.