bluuebunny/crossref_metadata_2025_split huggingface dataset:
Toward 1-km Ensemble Forecasts over Large Domains
Authors: Schwartz Craig S. , Romine Glen S. , Fossell Kathryn R. , Sobash Ryan A. , Weisman Morris L. 
Published: March 2017

AbstractPrecipitation forecasts from convection-allowing ensembles with 3- and 1-km horizontal grid spacing were evaluated between 15 May and 15 June 2013 over central and eastern portions of the United States. Probabilistic forecasts produced from 10- and 30-member, 3-km ensembles were consistently better than forecasts from individual 1-km ensemble members. However, 10-member, 1-km probabilistic forecasts usually were best, especially over the first 12 h and at rainfall rates ≥ 5.0 mm h−1 at later times. Further object-based investigation revealed that better 1-km forecasts at heavier rainfall rates were associated with more accurate placement of mesoscale convective systems compared to 3-km forecasts. The collective results indicate promise for 1-km ensembles once computational resources can support their operational implementation.
Anxiety and Depression as Longitudinal Predictors of Mild Cognitive Impairment in Older Adults
Authors: Freire Antônio Carlos Cruz , Pondé Milena Pereira , Liu Aihua , Caron Jean 
Published: March 2017

Introduction: Few studies have dealt with the potential correlation between anxiety, depression, and cognitive impairment in community-dwelling older adults. Method: This longitudinal study was conducted in the city of Montreal, Canada, with 352 older adults aged 55 years or more. The participants were interviewed at baseline and again 2 years later. The Montreal Cognitive Assessment (MoCA) score was estimated and compared between the 2 time points, the Composite International Diagnostic Interview (CIDI) was used to assess major depression and anxiety, and the K10 measured high psychological distress. Likewise, major depression, anxiety disorders, and psychological distress were evaluated at the 2 study time points. Results: In older adults with a diagnosis of depression or anxiety at baseline, no significant reduction in the MoCA score indicating deterioration in cognitive function was found 2 years later. Nevertheless, in individuals with a high level of psychological distress at baseline, there was a significant reduction in MoCA scores 2 years later, indicating deterioration in cognition. The findings of the present study suggest that a high level of psychological distress in addition to environmental factors may constitute important predictors for cognitive health.
Is Therapeutic Hypothermia for Acute Respiratory Distress Syndrome the Future?
Authors: Hayek Adam J. , White Heath D. , Ghamande Shekhar , Spradley Christopher , Arroliga Alejandro C. 
Published: March 2017

Introduction: Severe acute respiratory distress syndrome (ARDS) has a high mortality, and there is limited knowledge about management of severe ARDS refractory to standard therapy. Early evidence suggests that therapeutic hypothermia (TH) could be a viable treatment for acute respiratory failure. We present 2 cases where TH was successfully used to manage refractory ARDS on extracorporeal membrane oxygenation (ECMO) and a review of the literature around TH and acute respiratory failure. Results: We present 2 cases of ARDS secondary to H1N1 influenza and human metapneumovirus. Both patients were treated with the current evidence-based therapy for ARDS. Venovenous ECMO was used in both patients for refractory hypoxemia. Therapeutic hypothermia was applied for 24 hours with improved oxygenation. We did a review of the literature summarizing 38 patients in 10 publications where TH was successfully utilized in the treatment of acute respiratory failure. Conclusion: Therapeutic hypothermia may be a viable salvage therapy for ARDS refractory to the current evidence-based therapy but needs further evaluation.
A comparison of toxicities in acute myeloid leukemia patients with and without renal impairment treated with decitabine
Authors: Levine Lauren B , Roddy Julianna VF , Kim Miryoung , Li Junan , Phillips Gary , Walker Alison R 
Published: March 2017

Purpose There are limited data regarding the clinical use of decitabine for the treatment of acute myeloid leukemia in patients with a serum creatinine of 2 mg/dL or greater. Methods We retrospectively evaluated 111 patients with acute myeloid leukemia who had been treated with decitabine and compared the development of toxicities during cycle 1 in those with normal renal function (creatinine clearance greater than or equal to 60 mL/min) to those with renal dysfunction (creatinine clearance less than 60 mL/min). Results Notable differences in the incidence of grade ≥3 cardiotoxicity (33% of renal dysfunction patients vs. 16% of normal renal function patients, p = 0.042) and respiratory toxicity (40% of renal dysfunction patients vs. 14% of normal renal function patients, p = 0.0037) were observed. The majority of heart failure, myocardial infarction, and atrial fibrillation cases occurred in the renal dysfunction group. The odds of developing grade ≥3 cardiotoxicity did not differ significantly between patients with and without baseline cardiac comorbidities (OR 1.43, p = 0.43). Conclusions This study noted a higher incidence of grade ≥3 cardiac and respiratory toxicities in decitabine-treated acute myeloid leukemia patients with renal dysfunction compared to normal renal function. This may prompt closer monitoring, regardless of baseline cardiac comorbidities. Further evaluation of decitabine in patients with renal dysfunction is needed.
Hsa-miR-27b is up-regulated in cytomegalovirus-infected human glioma cells, targets engrailed-2 and inhibits its expression
Authors: Wang Linqian , Yang Ming , Liao Shijing , Liu Wei , Dai Gan , Wu Guojun , Chen Liyu 
Published: March 2017

Human cytomegalovirus (HCMV) dormant infection can alter the expression of the hosts’ microRNAs (miRNAs) and impact on the regulation of target genes. To investigate the differentially expressed miRNAs induced by HCMV in human glioma U251 cells, a comprehensive miRNA screen was performed. As a result, 19 up-regulated and 14 down-regulated miRNAs were determined. Of these, hsa-miR-27b (miR-27b) attracted our attention. MiR-27b levels in U251 cells increased 7.70-fold, 8.64-fold, and 4.78-fold, respectively, post 24 h, 48 h, and 72 h HCMV infection, compared to those in the mimic-infected cells, and this up-regulation was further confirmed by quantitative RT-PCR. The bioinformatic analyses show that miR-27b targets engrailed-2 (EN2) gene; however, the effect of miR-27b on EN2 is rarely encountered. In this study, we initially conducted dual luciferase assay to validate the target function of miR-27b on EN2. The results manifested that EN2 is a novel target of miR-27b, which could directly target the 3′ untranslated region (3′-UTR) of the gene. We further found that the miR-27b transfected glioma U251 cells exhibited longer cell bodies with more synapses and multiple-angle shapes; moreover, Western blot detection revealed that the EN2 protein levels in these cells were significantly low. In conclusion, our study originally reports the up-regulation of miR-27b in HCMV-infected glioma cells. Our study also provides the first experimental evidence that miR-27b could affect glioma cells’ growth, target EN2 and inhibit its expression in glioma cells. Our data indicate that miR-27b may be related to the development of neurological disorders with HCMV infection. The newly identified miR-27b/EN2 signal pathway may provide new insights into the glioma pathogenesis and a novel target for glioma therapy. Impact statement Our study is the first to demonstrate that the HCMV infection could alter the expression of cellular microRNAs of the host glioma cells, which may develop an understanding of the pathogenesis of the HCMV infection in the microRNA level. Recently, HCMV infection and engrailed-2 have been reported to be related to the autism spectrum disorder (ASD). In this study, we confirmed that engrailed-2 is the target of hsa-miR-27b. As far as we know, our findings of the hsa-miR-27b up-regulation in the HCMV-infected glioma cells, targeting engrailed-2 and inhibiting its expression have never been reported or documented. Our data indicate that miR-27b may be related to the development of neurological disorders with the HCMV infection. The newly identified miR-27b/EN2 signal pathway may provide new insights into the glioma pathogenesis and a novel target for glioma therapy.
Intestinal absorption and renal reabsorption of calcium throughout postnatal development
Authors: Beggs Megan R , Alexander R Todd 
Published: March 2017

Calcium is vital for many physiological functions including bone mineralization. Postnatal deposition of calcium into bone is greatest in infancy and continues through childhood and adolescence until peek mineral density is reached in early adulthood. Thereafter, bone mineral density remains static until it eventually declines in later life. A positive calcium balance, i.e. more calcium absorbed than excreted, is crucial to bone deposition during growth and thus to peek bone mineral density. Dietary calcium is absorbed from the intestine into the blood. It is then filtered by the renal glomerulus and either reabsorbed by the tubule or excreted in the urine. Calcium can be (re)absorbed across intestinal and renal epithelia via both transcellular and paracellular pathways. Current evidence suggests that significant intestinal and renal calcium transport changes occur throughout development. However, the molecular details of these alterations are incompletely delineated. Here we first briefly review the current model of calcium transport in the intestine and renal tubule in the adult. Then, we describe what is known with regard to calcium handling through postnatal development, and how alterations may aid in mediating a positive calcium balance. The role of transcellular and paracellular calcium transport pathways and the contribution of specific intestinal and tubular segments vary with age. However, the current literature highlights knowledge gaps in how specifically intestinal and renal calcium (re)absorption occurs early in postnatal development. Future research should clarify the specific changes in calcium transport throughout early postnatal development including mediators of these alterations enabling appropriate bone mineralization.Impact statementThis mini review outlines the current state of knowledge pertaining to the molecules and mechanisms maintaining a positive calcium balance throughout postnatal development. This process is essential to achieving optimal bone mineral density in early adulthood, thereby lowering the lifetime risk of osteoporosis.
Implant of permanent pacemaker during acute coronary syndrome: Mortality and associated factors in the ARIAM registry
Authors: Pola-Gallego-de-Guzmán María Dolores , Ruiz-Bailén Manuel , Martínez-Arcos Maria-Angeles , Gómez-Blizniak Artur , Castillo Rivera Ana-Maria , Molinos Jesus Cobo ,   the ARIAM group
Published: March 2017

Background: Patients with acute coronary syndrome complicated with high degree atrioventricular block still have a high mortality. A low percentage of these patients need a permanent pacemaker (PPM) but mortality and associated factors with the PPM implant in acute coronary syndrome patients are not known. We assess whether PPM implant is an independent variable in the mortality of acute coronary syndrome patients. Also, we explored the variables that remain independently associated with PPM implantation. Methods: This was an observational study on the Spanish ARIAM register. The inclusion period was from January 2001 to December 2011. This registry included all Andalusian acute coronary syndrome patients. Follow-up for global mortality was until November 2013. Results: We selected 27,608 cases. In 62 patients a PPM was implanted (0.024%). The mean age in PPM patients was 70.71±11.214 years versus 64.46±12.985 years in patients with no PPM. PPM implant was associated independently with age (odds ratio (OR) 1.031, 95% confidence interval (CI) 1.007–1.055), with left ventricular branch block (OR 6.622, 95% CI 2.439–18.181), with any arrhythmia at intensive care unit admission (OR 2.754, 95% CI 1.506–5.025) and with heart failure (OR 3.344, 95% CI 1.78–8.333). PPM implant was independently associated with mortality (OR 11.436, 95% CI 1.576–83.009). In propensity score analysis PPM implant was still associated with mortality (OR 5.79, 95% CI 3.27–25.63). Conclusion: PPM implant is associated with mortality in the acute coronary syndrome population in the ARIAM registry. Advanced age, heart failure, arrhythmias and left ventricular branch block at intensive care unit admission were found associated factors with PPM implant in acute coronary syndrome patient.
Oral and oropharyngeal cancer in the Middle East and North Africa
Authors: Kujan Omar , Farah Camile S , Johnson Newell W 
Published: March 2017

Objectives: Oral cavity and oropharyngeal cancer (OCC-OPC) is a major health problem worldwide. The Middle East and North Africa (MENA) region is constituted of 23 countries, with a heterogeneous population of over 448 million people. This is the first review to report collectively on the epidemiology and etiology of OCC-OPC in the MENA region. Methods: Data are derived from GLOBOCAN 2012. We searched the published literature databases to report risk factors of oral cancer in the MENA region. Results: Age-standardized incidence rates per 100,000 per annum are estimated by GLOBOCAN 2012 for males and females and these were 2.6 and 1.8, respectively. The age-standardized mortality rates of OCC-OPC for males and females were 1.1 and 0.7, respectively. Importantly, the crude incidence and mortality rates are projected to double by 2030 especially in Egypt, Iran, Morocco, Sudan, and Turkey. This increase is double that of the projected worldwide rate. Conclusion: Local governments and international agencies should collaborate to improve the standard of clinical services, preventive measures, and public awareness of oral cancer. Future research should be undertaken to improve the quality of registry reporting data for OCC-OPC.
Age‐related reduction and independent predictors of toe flexor strength in middle‐aged men
Authors: Suwa Masataka , Imoto Takayuki , Kida Akira , Iwase Mitsunori , Yokochi Takashi 
Published: March 2017

AbstractBackgroundToe flexor muscles play an important role in posture and locomotion, and poor toe flexor strength is a risk factor for falls. In this cross‐sectional study, we estimated the age‐related change in toe flexor strength and compared it with that of handgrip strength. Independent factors predicting toe flexor and handgrip strength were also determined.MethodsA total of 1401 male (aged 35–59 years) study participants were divided into five groups according to their chronological age; 35–39, 40–44, 45–49, 50–54, and 55–59 years. Toe flexor and handgrip strength, anthropometry, and resting blood pressure were measured. Fasting blood samples were collected to measure blood glucose, triglycerides, high‐ and low‐density lipoprotein‐cholesterols, and albumin. A self‐administered lifestyle questionnaire was conducted.ResultsDecline in absolute toe flexor and handgrip strength began in the age groups 50–55 and 55–59 years, respectively. In comparison to the mean values of the youngest group, relative toe flexor strength (87.0 ± 26.6%) was significantly lower than handgrip strength (94.4 ± 13.1%) for the oldest group. Multiple regression analyses showed that independent factors predicting both toe flexor and handgrip strength were lean body mass, age, serum albumin, drinking habit, and fat mass. Additionally, fasting blood glucose, diastolic blood pressure, sleeping time and exercise habit were predicting factors of toe flexor strength but not of handgrip strength.ConclusionsAge‐related reduction in toe flexor strength was earlier and greater than handgrip strength, and toe flexor strength reflects body composition and metabolic status.
Incidence and burden of comorbid pain and depression in patients with chronic rhinosinusitis awaiting endoscopic sinus surgery in Canada
Authors: Hanna Bassem M. N. , Crump R. Trafford , Liu Guiping , Sutherland Jason M. , Janjua Arif S. 
Published: March 2017

Background This study sheds important light on the association between sino-nasal symptoms and global quality of life in patients with chronic rhinosinusitis waiting for endoscopic sinus surgery. Using patient-reported information collected pre-operatively, the primary objective was to report on patients’ pre-surgical sino-nasal symptoms and their association with self-reported pain and depression. The secondary objective was to report on levels of depression and pain among patients in the sample reporting severe sleep problems. Methods This is a cross-sectional study of patient-reported outcomes collected prospectively from a cohort of 261 patients assigned to the wait list for elective endoscopic sinus surgery in a large urban region of Canada. Results Younger patients and patients with other medical comorbidities were most likely to report significant symptoms of chronic rhinosinusitis and substantial associated pain and depression. In the primary analyses, patients reporting significant symptoms of chronic rhinosinusitis were more likely to report moderate depression or high pain ( p < 0.01). Subsequently, chronic rhinosinusitis patients with severe sleep problems were 82% likely to report moderate or severe depression and pain. Conclusion Preoperative management of depression and pain may be considered in order to improve the health-related quality of life of patients waiting for ESS. As depression and pain were highly prevalent, patients with severe sleep problems may be candidates for prioritized access.
Fast search based on generalized similarity measure
Authors: Utsumi Yuzuko , Mizuno Tomoya , Iwamura Masakazu , Kise Koichi 
Published: March 2017

Abstract
This paper proposes a fast recognition method based on generalized similarity measure (GSM). The GSM achieves good recognition accuracy for face recognition, but has a scalability problem. Because the GSM method requires the similarity measures between a query and all samples to be calculated, the computational cost for recognition is in proportion to the number of samples. A reasonable approach to avoiding calculating all the similarity measures is to limit the number of samples used for calculation. Although approximate nearest neighbor search (ANNS) methods take this approach, they cannot be applied to the GSM-based method directly because they assume that similarity measure is the Euclidean distance. The proposed method embeds the GSM into the Euclidean distance so that it may be applied in existing ANNS methods. We conducted experiments on face, object, and character datasets, and the results show that the proposed method achieved fast recognition without dropping the accuracy.
Active Surveillance in Younger Men With Prostate Cancer
Authors: Leapman Michael S. , Cowan Janet E. , Nguyen Hao G. , Shinohara Katsuto K. , Perez Nannette , Cooperberg Matthew R. , Catalona William J. , Carroll Peter R. 
Published: March 2017

Purpose The suitability of younger patients with prostate cancer (PCa) for initial active surveillance (AS) has been questioned on the basis of eventual treatment necessity and concerns of safety; however, the role of age on surveillance outcomes has not been well defined. Patients and Methods We identified men managed with AS at our institution with a minimum follow-up of 6 months. The primary study objective was to examine the association of age with risk of biopsy-based Gleason score upgrade during AS. We also examined the association of age with related end points, including overall biopsy-determined progression, definitive treatment, and pathologic and biochemical outcomes after delayed radical prostatectomy (RP), using descriptive statistics, the Kaplan-Meier method, and multivariable Cox proportional hazards regression. Results A total of 1,433 patients were followed for a median of 49 months; 74% underwent initial biopsy at a referring institution. Median age at diagnosis was 63 years, including 599 patients (42%) ≤ 60 years old and 834 (58%) > 60 years old. The 3- and 5-year biopsy-based Gleason score upgrade-free rates were 73% and 55%, respectively, for men ≤ 60 years old compared with 64% and 48%, respectively, for men older than 60 years ( P < .01). On Cox regression analysis, younger age was independently associated with lower risk of biopsy-based Gleason score upgrade (hazard ratio per 1-year decrease, 0.969 [95% CI, 0.956 to 0.983]; P < .01), and persisted upon restriction to men meeting strict AS inclusion criteria. There was no significant association between younger age and risk of definitive treatment or risk of biochemical recurrence after delayed RP. Conclusion Younger patient age was associated with decreased risk of biopsy-based Gleason score upgrade during AS but not with risk of definitive treatment in the intermediate term. AS represents a strategy to mitigate overtreatment in young patients with low-risk PCa in the early term.
Brachytherapy for Patients With Prostate Cancer: American Society of Clinical Oncology/Cancer Care Ontario Joint Guideline Update
Authors: Chin Joseph , Rumble R. Bryan , Kollmeier Marisa , Heath Elisabeth , Efstathiou Jason , Dorff Tanya , Berman Barry , Feifer Andrew , Jacques Arthur , Loblaw D. Andrew 
Published: March 2017

Purpose To jointly update the Cancer Care Ontario guideline on brachytherapy for patients with prostate cancer to account for new evidence. Methods An Update Panel conducted a targeted systematic literature review and identified more recent randomized controlled trials comparing dose-escalated external beam radiation therapy (EBRT) with brachytherapy in men with prostate cancer. Results Five randomized controlled trials provided the evidence for this update. Recommendations For patients with low-risk prostate cancer who require or choose active treatment, low–dose rate brachytherapy (LDR) alone, EBRT alone, and/or radical prostatectomy (RP) should be offered to eligible patients. For patients with intermediate-risk prostate cancer choosing EBRT with or without androgen-deprivation therapy, brachytherapy boost (LDR or high–dose rate [HDR]) should be offered to eligible patients. For low-intermediate risk prostate cancer (Gleason 7, prostate-specific antigen < 10 ng/mL or Gleason 6, prostate-specific antigen, 10 to 20 ng/mL), LDR brachytherapy alone may be offered as monotherapy. For patients with high-risk prostate cancer receiving EBRT and androgen-deprivation therapy, brachytherapy boost (LDR or HDR) should be offered to eligible patients. Iodine-125 and palladium-103 are each reasonable isotope options for patients receiving LDR brachytherapy; no recommendation can be made for or against using cesium-131 or HDR monotherapy. Patients should be encouraged to participate in clinical trials to test novel or targeted approaches to this disease. Additional information is available at www.asco.org/Brachytherapy-guideline and www.asco.org/guidelineswiki .