bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of cinnamaldehyde amino acid Schiff base compounds based on the quantitative structure–activity relationship
Authors: Wang Hui , Jiang Mingyue , Li Shujun , Hse Chung-Yun , Jin Chunde , Sun Fangli , Li Zhuo 
Published: September 2017

Cinnamaldehyde amino acid Schiff base (CAAS) is a new class of safe, bioactive compounds which could be developed as potential antifungal agents for fungal infections. To design new cinnamaldehyde amino acid Schiff base compounds with high bioactivity, the quantitative structure–activity relationships (QSARs) for CAAS compounds against
Aspergillus niger
(
A. niger
) and
Penicillium citrinum (P. citrinum)
were analysed. The QSAR models (
R
2
= 0.9346 for
A. niger
,
R
2
= 0.9590 for
P. citrinum,
) were constructed and validated. The models indicated that the molecular polarity and the Max atomic orbital electronic population had a significant effect on antifungal activity. Based on the best QSAR models, two new compounds were designed and synthesized. Antifungal activity tests proved that both of them have great bioactivity against the selected fungi.
A Rescorla-Wagner Drift-Diffusion Model of Conditioning and Timing
Authors: Luzardo André , Alonso Eduardo , Mondragón Esther 
Published: September 2017

AbstractComputational models of classical conditioning have made significant contributions to the theoretic understanding of associative learning, yet they still struggle when the temporal aspects of conditioning are taken into account. Interval timing models have contributed a rich variety of time representations and provided accurate predictions for the timing of responses, but they usually have little to say about associative learning. In this article we present a unified model of conditioning and timing that is based on the influential Rescorla-Wagner conditioning model and the more recently developed Timing Drift-Diffusion model. We test the model by simulating 10 experimental phenomena and show that it can provide an adequate account for 8, and a partial account for the other 2. We argue that the model can account for more phenomena in the chosen set than these other similar in scope models: CSC-TD, MS-TD, Learning to Time and Modular Theory. A comparison and analysis of the mechanisms in these models is provided, with a focus on the types of time representation and associative learning rule used.Author SummaryHow does the time of events affect the way we learn about associations between these events? Computational models have made great contributions to our understanding of associative learning, but they usually do not perform very well when time is taken into account. Models of timing have reached high levels of accuracy in describing timed behaviour, but they usually do not have much to say about associations. A unified approach would involve combining associative learning and timing models into a single framework. This article takes just this approach. It combines the influential Rescorla-Wagner associative model with a timing model based on the Drift-Diffusion process, and shows how the resultant model can account for a number of learning and timing phenomena. The article also compares the new model to others that are similar in scope.
Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA splicing factors during adipogenesis
Authors: Mugabo Yves , Sadeghi Mina , Fang Nancy N. , Mayor Thibault , Lim Gareth E. 
Published: September 2017

AbstractAdipogenesis is facilitated by a complex signaling network requiring strict temporal and spatial organization of effector molecules. Molecular scaffolds, such as 14-3-3 proteins, coordinate such events, and we have previously identified 14-3-3ζ as an essential scaffold in adipocyte differentiation. The interactome of 14-3-3ζ is large and diverse, and it is possible that novel adipogenic factors may be present within it. Mouse embryonic fibroblasts from mice over-expressing a TAP-epitope-tagged 14-3-3ζ molecule were generated, and following the induction of adipogenesis, TAP-14-3-3ζ complexes were purified, followed by mass spectrometry analysis to determine the 14-3-3ζ interactome. Over 100 proteins were identified as being unique to adipocyte differentiation, of which 56 were novel interacting partners. Previously established regulators of adipogenesis (ie, Ptrf/Cavin1 and Phb2) were found within the 14-3-3ζ interactome, confirming the ability of this approach to identify regulators of adipocyte differentiation. An enrichment of proteins in the interactome related to RNA metabolism, processing, and splicing was identified, and analysis of transcriptomic data revealed that 14-3-3ζ depletion in 3T3-L1 cells affected the alternative splicing of mRNA during adipocyte differentiation. Of the RNA splicing factors within the 14-3-3ζ interactome, depletion of Hnrnpf, Hnrnpk, Ddx6, and Sfpq by siRNA revealed essential roles of these proteins in adipogenesis and their roles in the alternative splicing ofLpin1. In summary, novel adipogenic factors can be detected within the 14-3-3ζ interactome, and further characterization of additional proteins within the 14-3-3ζ interactome has the potential of identifying novel targets to block the expansion of adipose tissue mass that occurs in obesity.
Protective effect of estrogen against intervertebral disc degeneration is attenuated by miR-221 through targeting estrogen receptor
Authors: Bin Sheng , Youchao Yuan , Xiangyang Liu , Yi Zhang , Hongzhe Liu , Xiongjie Shen , Bin Liu , Lei Chang 
Published: September 2017

AbstractIntervertebral disc degeneration (IDD) is a multifactorial disease that associates apoptosis, senescence and calcification of cartilage cells, inflammatory response and alterations in the extracellular matrix. Previous documents imply that estrogen and miR-221 may be involved in IDD. This study further investigated their regulatory mechanisms underlying IDD. Normal and degenerated cartilaginous endplates (CEP) tissues were isolated surgically from juvenile patients with idiopathic scoliosis and adult patients with IDD, respectively. PCR and western blot assays showed decreased aggrecan, Col2A1, TGF-β and estrogen receptorα (ERα) levels in CEP, but increased MMP-3, adamts-5, IL-1β, TNF-α, IL-6 and miR-221 levels. CEP cells were harvested from degenerated CEP tissues and treated with doses of 17β-E2. 17β-E2 increased expression of aggrecan and Col2A1 levels in endplate chondrocytes and secretion of TGF-β, but decreased IL-6 secretion. Moreover, 17β-E2 inhibited the apoptosis and cell-cycle arrest in G0/G1, improving the cell viability. These data indicated estrogen confers protective effect against IDD. However, we found that ERα was a target of miR-221 via luciferase assay. miR-221 up-regulation via the mimics or ERα knockdown attenuated these protective effects conferred by estrogen, while intervention of miR-221 via the inhibitors promoted the protective effects. This study provided novel evidence that estrogen confers protective effects of CEP against IDD, however, up-regulated miR-221 in degenerated CEP decreased the protective effects via targeting ERα, thus it may be an important cause for IDD.
Glutamine metabolism regulates Th2 cell differentiation via the α-ketoglutalate-dependent demethylation of histone H3K27
Authors: Kuwahara Makoto , Izumoto Maya , Honda Hiroaki , Inoue Kazuki , Imai Yuuki , Suzuki Junpei , Maruyama Saho , Yasukawa Masaki , Yamashita Masakatsu 
Published: September 2017

AbstractThe acquisition of T cell functions seems to be closely linked to the reprogramming of the metabolic pathway. However, the impact of metabolic changes on the differentiation of helper T cell subsets remains unclear. We found that TCR-mediated activation of glutamine metabolism regulates Th2 cell differentiation via the supplementation of α-ketogulutalate (α-KG) and histone H3K27 demethylation. Deprivation of glutamine or pharmacological inhibition of glutamine metabolism blocks the induction of Th2 cell differentiation without affecting Stat6 phosphorylation. The methylation status of H3K27 at the Th2 cytokine gene locus was significantly increased in Th2 cells cultured under glutamine-deprived conditions. The inhibitory effect of glutamine-deprivation was antagonized by α-KG, and the α-KG-dependent induction of Th2 cell differentiation was reduced inutx-andjmjd3-deficientnaïve CD4 T cells. These findings show that the glutamine-a-ketoglutarate axis is crucial to regulating the epigenetic status at the Th2 cytokine gene locus and subsequent Th2 cell differentiation.
Interoperable genome annotation with GBOL, an extendable infrastructure for functional data mining
Authors: van Dam Jesse C.J. , Koehorst Jasper J. , Vik Jon Olav , Schaap Peter J. , Suarez-Diez Maria 
Published: September 2017

BackgroundA standard structured format is used by the public sequence databases to present genome annotations. A prerequisite for a direct functional comparison is consistent annotation of the genetic elements with evidence statements. However, the current format provides limited support for data mining, hampering comparative analyses at large scale.ResultsThe provenance of a genome annotation describes the contextual details and derivation history of the process that resulted in the annotation. To enable interoperability of genome annotations, we have developed the Genome Biology Ontology Language (GBOL) and associated infrastructure (GBOL stack). GBOL is provenance aware and thus provides a consistent representation of functional genome annotations linked to the provenance. GBOL is modular in design, extendible and linked to existing ontologies. The GBOL stack of supporting tools enforces consistency within and between the GBOL definitions in the ontology (OWL) and the Shape Expressions (ShEx) language describing the graph structure. Modules have been developed to serialize the linked data (RDF) and to generate a plain text format files.ConclusionThe main rationale for applying formalized information models is to improve the exchange of information. GBOL uses and extends current ontologies to provide a formal representation of genomic entities, along with their properties and relations. The deliberate integration of data provenance in the ontology enables review of automatically obtained genome annotations at a large scale. The GBOL stack facilitates consistent usage of the ontology.
Knockdown of Hypocretin/Orexin Attenuates Extended-Access Cocaine Self-Administration in Rats
Authors: Schmeichel Brooke E. , Matzeu Alessandra , Koebel Pascale , Vendruscolo Leandro F. , Kieffer Brigitte L. , Koob George F. , Martin-Fardon Rémi , Contet Candice 
Published: September 2017

AbstractThe hypocretin/orexin (HCRT) neuropeptide system regulates feeding, arousal state, stress responses, and reward, especially under conditions of enhanced motivational relevance. In particular, HCRT neurotransmission facilitates drug-seeking behavior in circumstances that demand increased effort and/or motivation to take the drug. The present study used a shRNA-encoding adeno-associated viral vector to knockdownHcrtexpression throughout the dorsal hypothalamus in adult rats and determine the role of HCRT in cocaine self-administration. LongtermHcrtsilencing did not impact cocaine self-administration under short-access conditions, but robustly attenuated cocaine intake during extended self-administration access, a model that mimics key features of compulsive cocaine-taking. In addition,Hcrtsilencing decreased motivation for both cocaine and palatable food (i.e., sweetened condensed milk; SCM) under a progressive ratio schedule of reinforcement, but did not alter responding for SCM under a fixed ratio schedule. Importantly,Hcrtsilencing did not affect food or water consumption, and had no consequence to general measures of arousal-dependent behaviors.At the molecular level, longtermHcrtknockdown moderately reduced the downstream expression of dynorphin (DYN) and melanin-concentrating hormone (MCH) in the dorsal hypothalamus.These original findings support the hypothesis that HCRT neurotransmission promotes operant responding for both drug and non-drug rewards, preferentially under conditions requiring a high degree of motivation. Furthermore, the current study provides compelling evidence for the involvement of the HCRT system in cocaine self-administration also under low-effort conditions in rats allowed extended access,possibly via functional interactions with DYN and MCH signaling.
The presentation of the self and professional identity: countering the accountant’s stereotype
Authors: Parker Lee D. , Warren Samantha 
Published: September 2017

PurposeThe purpose of this paper is to explore the intersection of professional values and career roles in accountants’ presentations of their professional identity, in the face of enduring stereotyping of the accounting role.Design/methodology/approachThis study presents a qualitative investigation of accountants’ construction of their professional identities and imagery using a Goffmanian dramaturgical perspective. Viewing professional identity construction as a presentational matter of impression management, the investigation employs a reflexive photo-interviewing methodology.FindingsAccountants use a variety of workplace dramatisation, idealisation and mystification strategies inside and outside the workplace to counter the traditional accounting stereotype. They also attempt to develop a professional identity that is a subset of their overall life values.Research limitations/implicationsTheir professional orientation is found to embrace role reconstruction and revised image mystification while not necessarily aiming for upward professional mobility. This has implications for understanding the career trajectories of contemporary accountants with associated implications for continuing professional development and education.Originality/valueThe paper focusses on professional role, identity, values and image at the individual accountant level, while most prior research has focussed upon these issues at the macro association-wide level. In offering the first use of reflexive photo-interviewing method in the accounting research literature, it brings the prospect of having elicited different and possibly more reflective observations, reflections and understandings from actors not otherwise possible from more conventional methods.
Robust launch vehicle’s generalized dynamic inversion attitude control
Authors: Ansari Uzair , Bajodah Abdulrahman H. 
Published: September 2017

Purpose
To design a robust attitude control system for the ascent flight phase of satellite launch vehicles (SLVs).

Design/methodology/approach
The autopilot is based on generalized dynamic inversion (GDI). Dynamic constraints are prescribed in the form of differential equations that encapsulate the control objectives, and are generalized inverted using the Moore-Penrose Generalized Inverse (MPGI) based Greville formula to obtain the control law. The MPGI is modified via a dynamic scaling factor for assuring generalized inversion singularity-robust tracking control. An additional sliding mode control (SMC) loop is augmented to robustify the GDI closed-loop system against model uncertainties and external disturbances.

Findings
The robust GDI control law allows for two cooperating controllers that act on two orthogonally complement control spaces: one is the particular controller that realizes the dynamic constraints, and the other is the auxiliary controller that is affined in the null control vector, and is used to enforce global closed-loop stability.

Practical implications
Orthogonality of the particular and the auxiliary control subspaces ensures noninterference of the two control actions, and thus, it ensures that both actions work toward a unified goal. The robust control loop increases practicality of the GDI control design.

Originality/value
The first successful implementation of GDI to the SLV control problem.
On the maximal and minimal distances of flying-around satellite formation
Authors: Dang Zhaohui , Fan Li , Wang Zhaokui , Zhang Yulin 
Published: September 2017

Purpose
The purpose of this paper is to present the obtained analytic solutions of maximal and minimal inter-satellite distances for flying-around satellite formation.

Design/methodology/approach
The relative motion equation is used to express the inter-satellite distance as the function of the orbital elements of two participating satellites for the flying-around satellite formation. Then by taking the derivative of the distance function with respect to the true anomaly, some possible extreme value points are obtained. According to the detailed analysis, the maximal and minimal distance solutions are found. By a reverse process, the expected initial differential orbital elements that generate the required extreme inter-satellite distances are also obtained.

Findings
The maximal and minimal distances of the flying-around formation can be analytically written as the functions of three initial orbital elements differences, i.e. the differential orbital inclination, the differential eccentricity and the differential right ascension. For the given maximal and minimal distances, there are lots of solutions of the initial differential orbital elements, which can produce the expected relative motions.

Research limitations/implications
The solutions of the maximal and minimal inter-satellite distances are only accurate for the circular or near circular reference orbit. For the elliptic reference orbit, there is a need to develop new methods to find the analytic solutions.

Practical implications
The results here can be applied to design the factual flying-around formation with dimension requirements in mission analysis stage.

Originality/value
By using the solutions presented in this paper, the engineers can design the expected flying-around formation with required maximal and minimal inter-satellite distances in a very easy way.
The cognitive underpinnings of effective teamwork: a continuation
Authors: Mesmer-Magnus Jessica , Niler Ashley A. , Plummer Gabriel , Larson Lindsay E. , DeChurch Leslie A. 
Published: September 2017

Purpose
Team cognition is known to be an important predictor of team process and performance. DeChurch and Mesmer-Magnus (2010) reported the results of an extensive meta-analytic examination into the role of team cognition in team process and performance, and documented the unique contribution of team cognition to these outcomes while controlling for the motivational dynamics of the team. Research on team cognition has exploded since the publication of DeChurch and Mesmer-Magnus’ meta-analysis, which raises the question: to what extent do the effect sizes reported in their 2010 meta-analysis still hold with the inclusion of newly published research? The paper aims to discuss this issue.

Design/methodology/approach
The authors updated DeChurch and Mesmer-Magnus’ meta-analytic database with newly published studies, nearly doubling its size, and reran their original analyses examining the role of team cognition in team process and performance.

Findings
Overall, results show consistent effects for team cognition in team process and performance. However, whereas originally compilational cognition was more strongly related to both team process and team performance than was compositional cognition, in the updated database, compilational cognition is more strongly related to team process and compositional cognition is more strongly related to team performance.

Originality/value
Meta-analyses are only as generalizable as the databases they are comprised of. Periodic updates are necessary to incorporate newly published studies and confirm that prior findings still hold. This study confirms that the findings of DeChurch and Mesmer-Magnus’ (2010) team cognition meta-analysis continue to generalize to today’s teams.
Parameter identification of wireless power transfer with a movable receiver
Authors: Wang Quandi , Wang Yingcong , Kang Jianwei , Li Wanlu 
Published: September 2017

Purpose
The purpose of this paper is to present a monitoring method for a three-coil wireless power transfer (WPT) system, which consists of a transmitting coil (Tx), a relay coil and a movable receiving coil (Rx). Both an ideal resistance and a rectifier bridge load are taken into account.

Design/methodology/approach
From the perspective of fundamental component, the equivalent impedance of a rectifier bridge load is well analyzed. On the basis of the circuit model of a three-coil WPT, estimation equations of the variable mutual inductances and load condition are deduced. Multi-frequency input impedance obtained by frequency scans combined with the Newton-Raphson method are used to obtain solutions.

Findings
Experimental results indicate that the estimated parameter values are close to each other when different sets of source frequencies are applied. When compared with simulation results, these estimated parameters including both mutual inductances and load resistances are found to be accurate.

Originality/value
Using only the information of input side, the proposed algorithm can estimate the mutual inductances and load resistance regardless of the Rx positions. Estimation is feasible for the system with a rectifier bridge load. The estimated analysis will serve as a key step in load power stabilization for WPT systems.
An investigation on frequency characteristics of wireless power transfer systems with relay resonators
Authors: Zhou Jiali , Zhang Bo , Qiu Dongyuan 
Published: September 2017

Purpose
This paper aims to analyze the frequency characteristics of wireless power transfer (WPT) systems with relay resonators in terms of the power delivered to the load and system efficiency. Based on the analytical results, system parameters can be optimized to achieve maximum power transfer and higher system efficiency.

Design/methodology/approach
Based on Kirchhoff’s voltage law equations, WPT systems with relay resonators are described by the coupled linear second-order differential equations. Splitting frequencies are estimated by using the matrix theory. In addition, critical coupling conditions are demonstrated based on discriminant analysis.

Findings
It was found that multi-maximum values exist for the power delivered to the load and total system efficiency owing to multiple eigenfrequencies of the system. Also, frequency conditions of maximum power transfer and system efficiency, as well as their critical coupling conditions, were quantitatively estimated.

Research limitations/implications
During our analytical process, we assume that quality factors of resonators in the system are high and the crossing coupling between resonators is negligible.

Originality/value
In previous works, the exact analysis of frequency characteristics is limited to WPT systems with two resonators. The appealing feature of this work lies in its ability to present a simplified analytical method with negligible approximation errors for WPT systems with relay resonators.
A numerical method for solving the physics-based model of IGBT with all free-carrier injection conditions in the base region
Authors: Chen Jiajia , Ma Yuhan , Yang Shiyou 
Published: September 2017

PurposeThe purpose of this paper is to provide an accurate model and method to simulate the transient performances of an insulated gate bipolar transistor (IGBT) in an arbitrary free-carrier injection condition.Design/methodology/approachA numerical model and method for solving the physics-based model, an ambipolar diffusion equation-based model, of an IGBT is proposed.FindingsThe results of the proposed model are very close to the tested ones.Originality/valueA mathematical model for an IGBT considering all free-carrier injection conditions is introduced, and a numerical solution methodology is proposed.