bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Educational and Psychoeducational Self‐Management Interventions in Children and Adolescents With Type 1 Diabetes: A Systematic Review and Meta‐Analysis
Authors: Cockcroft Emma. J. , Clarke Ross , Dias Renuka. P. , Lloyd Jenny , Mann Robert H. , Narendran Parth , Reburn Charlotte , Smith Ben , Smith Jane R. , Andrews Robert. C. 
Published: October 2024

Aim: Type 1 diabetes (T1D) is one of the most common chronic conditions in children and adolescents. Approximately 1.5 million young people are currently living with T1D throughout the world. Despite recent improvement in overall indices of metabolic control in children and adolescents with T1D, control remains suboptimal and additional approaches are needed. The aim of the study was to conduct a systematic review and meta‐analysis of educational and psychoeducational self‐management interventions, to help optimize future interventions including physical activity support.Methods: A systematic review and meta‐analysis were conducted according to our registered protocol (PROSPERO CRD42022295932) and are reported in line with the PRISMA 2020 guidance. We searched five databases (MEDLINE, EMBASE, PsycINFO [via Ovid], CINAHL [via EBSCO], Cochrane Library) from 1994 up to May 2024. We included randomized controlled trials assessing the effectiveness of self‐management interventions. Outcomes of interest included HbA1c and quality of life (QoL) as well as self‐care behaviors, diabetes knowledge, and self‐efficacy. Meta‐analyses were conducted using a random effects model.Results: In total, 46 papers were included, reporting on 30 interventions. Meta‐analyses showed small short‐term improvements in HbA1c (MD = −2.58 mmol/L, 95% CI −4.44 to −0.71, p = 0.007) and QoL (mean difference [MD] = 1.37, 95% CI 0.19–2.54, p = 0.02). Prespecified subgroup analyses suggested no significant difference in effectiveness of psychoeducational and education‐only interventions. Quality of included studies was low with 27 having a high risk of bias.Conclusion: There is a lack of robust evidence that current self‐management interventions result in clinically meaningful improvements in HbA1c and QoL. Future research should focus on redefining approaches to supporting and encouraging self‐management.
Targeting Matrix Metalloproteinase‐3 for Dental Caries Prevention Using Herbal Isolates: MMP3 Inhibition by Cinnamic Acids
Authors: Salman Mahdieh , Asgartooran Bahareh , Taherkhani Amir 
Published: October 2024

Objectives: Dental caries, a prevalent infectious disease affecting teeth, ranks highest among 328 diseases, according to a 2017 Lancet study. In demineralized human dentin, matrix metalloproteinase‐3 (MMP3) functions as a proteoglycanase, contributing to the degradation of proteoglycan components. This process exposes collagen fibrils, thereby facilitating the demineralization of the dentin matrix. Inhibiting MMP3 shows potential for preventing dental caries.Methods: The binding affinity of 20 cinnamic acid derivatives, namely cynarin, chlorogenic acid, rosmarinic acid, cinnamyl caffeate, phenethyl caffeate, N‐p‐coumaroyltyramine, caffeic acid 3‐glucoside, caffeic acid phenethyl ester, roscovitine, benzyl caffeate, o‐coumaric acid, artepillin C, caffeic acid, methyl caffeate, 2‐methylcinnamic acid, ferulic acid, drupanin, p‐coumaric acid, cinnamic acid, and sinapinic acid, to the MMP3 catalytic cleft, was assessed utilizing AutoDock 4.0. Molecular dynamics simulation was then employed to analyze the stability of backbone atoms in free MMP3, MMP3‐positive control inhibitor, and MMP3 complexed with the top‐ranked cinnamic acid over a 100 ns computer simulation.Results: Four cinnamic acids demonstrated ΔGbinding scores below −10 kcal/mol, with cynarin emerging as the most potent MMP3 inhibitor, featuring a ΔGbinding score and inhibition constant value of −15.57 kcal/mol and 3.83 pM, respectively. The MMP3–cynarin complex exhibited stability after a 50 ns computer simulation, showing a root‐mean‐square deviation of 8 Å.Conclusions: The inhibition of MMP3 by cynarin, chlorogenic acid, rosmarinic acid, and cinnamyl caffeate holds promise as a potential preventive strategy for dental caries.
Complement Factor H Is an ICOS Ligand Modulating Tregs in the Glioma Microenvironment
Authors: Smolag Karolina I. , Olszowka Jakub , Rosberg Rebecca , Johansson Elinn , Marinko Elisabet , Leandersson Karin , O’Connell David J. , Governa Valeria , Tuysuz Emre Can , Belting Mattias , Pietras Alexander , Martin Myriam , Blom Anna M. 
Published: October 2024

Abstract
The survival rate of patients with glioma has not significantly increased in recent years despite aggressive treatment and advances in immunotherapy. The limited response to treatments is partially attributed to the immunosuppressive tumor microenvironment, in which regulatory T cells (Treg) play a pivotal role in immunologic tolerance. In this study, we investigated the impact of complement factor H (FH) on Tregs within the glioma microenvironment and found that FH is an ICOS ligand. The binding of FH to this immune checkpoint molecule promoted the survival and function of Tregs and induced the secretion of TGFβ and IL10 while suppressing T-cell proliferation. We further demonstrated that cancer cells in human and mouse gliomas directly produce FH. Database investigations revealed that upregulation of FH expression was associated with the presence of Tregs and correlated with worse prognosis for patients with glioma. We confirmed the effect of FH on glioma development in a mouse model, in which FH knockdown was associated with a decrease in the number of ICOS+ Tregs and demonstrated a tendency of prolonged survival (P = 0.064). Because the accumulation of Tregs represents a promising prognostic and therapeutic target, evaluating FH expression should be considered when assessing the effectiveness of and resistance to immunotherapies against glioma.
Transfer-learning based skin cancer diagnosis using fine-tuned AlexNet by Marine Predators Algorithm
Authors: Ibrahim Khaleel Maha , Lakizadeh Amir 
Published: October 2024

<span>Melanoma represents one of the most dangerous manifestations of skin cancer. According to statistics, 55% of patients with skin cancer have lost their lives as a result of this disease. Early diagnosis of this condition will significantly reduce mortality rates and save lives. In recent years, deep learning methods have shown promising results and captured the attention of researchers in this field. One common approach is the use of pre-trained deep neural networks. In this work, a pre-trained AlexNet networks, which are networks with specified architecture and weights is used to automatic skin melanoma diagnosis. In the transfer learning phase, by reducing the learning rate, the pre-trained network is trained to recognize Skin cancer, which is called fine-tuning. In addition, Hyperparameters of the AlexNet network have been optimized by the Marine Predators Algorithm (MPA) to enhance the network performance. Experimental findings show the satisfactory efficiency of the presented approach, with an accuracy rate of 98.47%. The outcomes demonstrate the effectiveness of the suggested approach in contrast to alternative existing methods.</span>
The comparatist fervor. Transfers, contagions and influences in history and social sciences
Authors: Ríos Gordillo Carlos Alberto 
Published: October 2024

Abstract
How do scientific research methods circulate?1 Why do they acquire, at a given moment, such dynamism and fecundity in various disciplines? How did the comparative fervor catch on in the social sciences of the 19th and 20th centuries, resulting in comparative history and global history in the Annales project? The field of transfers through which the comparative method circulated between Victorian anthropology, Durkheimian sociology and the linguistics associated with it and history, through the pen of French-speaking medievalists, explains the dynamism of transmissions and contagions, of crossed, filtered or direct influences. This interplay of exchanges between disciplines, authors and books represents a moment in the history of the comparative method, in which it was considered a paradigm of renewal in the disciplines in which it was practiced, as well as for the social sciences of its time.
Within the French methodological tradition, the relations between comparative history and global history are close. The scales of comparison make it possible to characterize civilizations, societies and economies, and to measure their dimensions in different times and spaces. But the latter corresponds to differences of social milieu and historical peculiarities, which are an original innovation, the result of historians’ borrowings from and rejections of other social scientists. In this comparative fervour the games of intellectual exchange defined comparative history as the history of civilizations considered in the long term.
7. Scènes éphémères à l’épreuve du virtuel (XVe-XVIe s.)
Authors: Doudet Estelle , Wawrzyniak Natalia 
Published: October 2024

Dans la plupart des pays européens, avant la seconde moitié du XVIe siècle, le spectacle dramatique s’est joué sans théâtre ; les performances avaient lieu dans des espaces urbains variés, accueillant des espaces scéniques adaptés aux occasions de représentation. La reconstruction en réalité virtuelle de ces scènes occasionnelles et éphémères, tréteaux ou aires de jeu entourées de gradins, soulève des questions différentes de la restitution 3D de bâtiments théâtraux car les archives sur ces constructions ponctuelles sont souvent lacunaires et rarement étudiées. Dès lors, que peut-on reconstruire en réalité virtuelle et pour quoi faire ? L’article montre comment ces questions de recherche peuvent nourrir les formations pédagogiques, à travers l’exemple des spectacles des XVe et XVIe siècles remis en scène par les étudiants de l’Atelier de recherche créative en histoire des arts du spectacle (ARCHAS, Université de Lausanne).
In most European countries, before the second half of the sixteenth century, dramatic performances took place without theatres; performances were hosted in various urban spaces transformed into stages suitable for the occasion. The virtual reconstruction of these occasional and ephemeral scenes, stages, or playing areas surrounded by bleachers, raises different questions from those emerging from the 3D restoration of theatrical buildings because archival traces of these temporary constructions are often incomplete and seldom studied. Therefore, what can be reconstructed in virtual reality and for what purpose? The article demonstrates how these research questions can enrich educational programs, through the example of the spectacles of the fifteenth and sixteenth centuries restaged by students of the Creative Research Workshop in the History of Performing Arts (ARCHAS, University of Lausanne).
9. Entretien avec Sandrine Dubouilh et Nicolas Patin : « Confronter nos savoirs »
Authors: Dubouilh Sandrine , Patin Nicolas 
Published: October 2024

Lors du colloque Repenser les lieux de spectacle de la première modernité (Bordeaux, 2022), l’historien Nicolas Patin a animé, avec la chercheuse spécialiste de scénographie et d’architecture théâtrale, Sandrine Dubouilh, une session de « gameplay historique », dans le cadre du projet pédagogique Montaigne in Game. Deux espaces de spectacle ont donné lieu à des échanges entre les deux chercheurs et le public : le théâtre de Dionysos d’Athènes dans la Grèce classique de Assassin’s Creed Odyssey (Ubisoft, 2018) et l’Alhambra Music Hall de Londres de 1868 dans Assassin’s Creed : Syndicate (Ubisoft, 2015). Cet entretien est l’occasion de revenir sur les apports et les limites de cette expérience un peu différente (et rafraichissante) de la recherche et de la pédagogie.
As part of the Montaigne in Game educational project, historian Nicolas Patin and theatrical architecture and scenography professor Sandrine Dubouilh, led a ‘historical gameplay’ session at Repenser les lieux de spectacle de la première modernité conference (Bordeaux, 2022). Two performance spaces provided the opportunity for dialogue between the two researchers and the audience: the Theatre of Dionysus in Classical Athens from Assassin's Creed Odyssey (Ubisoft, 2018) and the Alhambra Music Hall in London in 1868 from Assassin's Creed: Syndicate (Ubisoft, 2015). This conversation is an opportunity to look back at the contributions and limitations of this non-traditional (and refreshing!) experience of research and pedagogy.
10. Exposition virtuelle
Authors: de Sédouy Louise 
Published: October 2024

Bordeaux et ses théâtres virtuels est une exposition qui propose de découvrir une quinzaine de projets de lieux de spectacle bordelais, de la fin du XVIIIe siècle au début du XXe. Ce parcours est l’occasion d’interroger des projets oubliés qui n’ont pas été construits et témoignent des envies du passé.
Bordeaux et ses théâtres virtuels is an exhibition that shows more than a dozen performance venues projected in Bordeaux between the end of the eighteenth century and the beginning of the twentieth. This exhibit interrogates the value of forgotten projects and provides a window into architectural dreams of the past.
12. Zones de conflit
Authors: Connors Logan J. 
Published: October 2024

Cet article décrit le rôle d’une expérience théâtrale virtuelle dans la création et l’évaluation d’expériences théâtrales réelles, en particulier dans les lieux à forte présence militaire pendant la seconde moitié du XVIIIe siècle. Dans une première partie, un panorama de plusieurs initiatives de création et de construction théâtrales dans les villes militarisées de France, en province et dans les colonies, permet de montrer l’ampleur des relations militaires-théâtrales à cette époque. Dans une seconde partie, on propose une étude de cas pour mieux comprendre les contours humains et expérientiels de ces initiatives théâtrales. Il s’agit d’une analyse de la ville de Brest, probablement la ville la plus militarisée de l’espace Atlantique francophone au XVIIIe siècle. Nous espérons expliquer comment la virtualisation du théâtre et de ses effets a influencé de véritables décisions concernant les fonds gouvernementaux, la localisation des nouveaux lieux de spectacle, l’urbanisation et l’embellissement des centres-villes ainsi que les jugements critiques envers ces environnements de performance.
This article describes the role of a virtual theatrical experience in the creation and evaluation of real theatrical experiences and, in particular, in places of strong military presence during the second half of the eighteenth century. Provided in the first part is an overview of several initiatives of theatrical creation and construction in militarized cities of provincial and colonial France with the aim of showing the extent of military-theatrical relations at the time. In a second part, a case study of theatre’s development in the city of Brest – possibly the most militarized place in the eighteenth-century French-speaking Atlantic – is proposed to better understand the human and experiential contours of these theatrical initiatives. With an analysis of the justifications and critiques of military presence in theatre, the goal is to explain how mental virtualizations of theater and its effects influenced real decisions about government funds, the location of new performance venues, urbanization, and the beautification of city centers as well as critical judgments towards these performance environments.
14. Entretien avec Olivier Aubert et Françoise Rubellin. « Comme de la pâte à modeler »
Authors: Beaucé Pauline , Leichman Jeffrey M. , Aubert Olivier , Rubellin Françoise 
Published: October 2024

Cet entretien a pour objectif de contextualiser des questions qui parcourent en filigrane plusieurs des contributions présentées dans le volume Nouvelles études sur les lieux de spectacle de la première modernité, consacré au renouvellement des études sur lieux de spectacle du passé. En conversation avec les éditeurs du volume, Olivier Aubert, chercheur en informatique, et Françoise Rubellin, professeure de littérature française du XVIIIe siècle, interroge la place que tiennent les humanités numériques dans les travaux en littérature et en histoire du théâtre (bases de données, modélisations, réalité virtuelle, réflexions théoriques…) et abordent certains enjeux qui concernent plus largement la communauté de la recherche en sciences humaines.
The aim of this discussion is to provide a context for questions that run through several of the contributions presented in the volume Nouvelles études sur les lieux de spectacle de la prmière modernité, devoted to the renewal of studies of past performance spaces. In conversation with the editors, Olivier Aubert, a researcher in computer science, and Françoise Rubellin, a professor of eighteenth-century French literature, reflect on the role played by the digital humanities in work on literature and the history of theatre (databases, 3D modelling, virtual reality, theoretical considerations, etc.) and discuss issues of broad concern to the contemporary humanities research community.
Opportunities and Barriers for Skillful Subseasonal Prediction of East Asian Summer Precipitation
Authors: Liu Fei , Zhou Jiahui , Wang Bin , Leung Jeremy Cheuk-Hin , Chen Deliang , Lin Zhongda , Kang In-Sik , Chao Qingchen , Ke Zongjian , Fan Ke , Liu Boqi , Huang Gang , Hsu Pang-chi , Dong Wenjie 
Published: October 2024

Abstract
Accurate subseasonal (2–8 weeks) prediction of monsoon precipitation is crucial for mitigating flood and heatwave disasters caused by intraseasonal variability (ISV). However, current state-of-the-art subseasonal-to-seasonal (S2S) models have limited prediction skills beyond 1 week when predicting weekly precipitation. Our findings suggest that predictability primarily arises from strong ISV events, and the prediction skills for ISV events depend on the propagation stability of preceding signals, regardless of models. This allows us to identify opportunities and barriers (OBs) within S2S models, clarifying what the models can and cannot achieve in ISV event prediction. Focusing on the complex East Asian summer monsoon (EASM), we discover that stable propagation of Eurasian and tropical atmospheric wave trains toward East Asia serves as an opportunity. This opportunity offers a 1-week leading prediction skill of up to 0.85 and skillful prediction up to 13 days ahead for 43% of all ISV events. However, the Tibetan Plateau barrier highlights the limitation of EASM predictability. Identifying these OBs will help us gain confidence in making more accurate subseasonal prediction.
A Slower North Equatorial Countercurrent but Faster Equatorial Undercurrent in a Warming Climate
Authors: Li Zhiyuan , Fedorov Alexey V. 
Published: October 2024

Abstract
We analyze century-end projections for the tropical Pacific upper-ocean currents simulated within phase 6 of the Coupled Model Intercomparison Project (CMIP6) under global warming. We find that while the intensity of precipitation within the intertropical convergence zone (ITCZ) increases, the ITCZ also shifts toward the equator and broadens, which reduces wind stress curl north of the equator. Consequently, the North Equatorial Countercurrent (NECC) shifts equatorward, following the ITCZ, and weakens, despite the more intense ITCZ. The strength of the North Equatorial Current (NEC) and the South Equatorial Current (SEC) also decreases due to the weakening of the Walker circulation and the corresponding wind stress. However, despite the weaker winds, the Equatorial Undercurrent (EUC) intensifies as it shoals due to stronger vertical stratification induced by surface warming. Furthermore, we find a slightly stronger zonal pressure gradient along the core of the EUC, instead of a weaker one expected from weaker wind stress and sea surface height (SSH) gradient along the equator. Ultimately, we suggest that the reduced vertical friction, driven by enhanced ocean stratification and a higher Richardson number, is essential for the accelerated EUC. These intricate balances control future changes in equatorial currents, and the uncertainties of projected changes need to be further examined.
Social branding for health promotion against non-communicable diseases in Maharashtra, India
Authors: Rajashekhar M , Sharma Radhika , Raut Abhishek V , Kalantri Ashwini , Gupta Subodh S ,   the VCaN Collaboration Team
Published: October 2024

Introduction: The burden of non-communicable diseases (NCDs) is a major challenge for countries, regardless of their level of development. Social branding is an emerging approach to health promotion for NCD prevention. In this paper, the process of social branding is documented as a case study to help researchers develop similar kinds of interventions in the settings in which they work. Methods: The process of developing a social brand is documented through conversations with the project team, observations in the field, interaction with community local members, and information gathered through photographs, videos and newspaper clippings. Results: The social brand focused upon in this study was named the Aarogyachi Vaari (Health Pilgrimage) inspired by the Pandrapur Wari, a religious pilgrimage undertaken in the state of Maharashtra, India. Various stakeholders from self-help groups, panchayat raj institutions and schools from the local village collaborated successfully to implement the health event in a manner similar to the way in which diverse religious groups come together for the Pandrapur Wari religious pilgrimage. The Aarogyachi Vaari took the form of a strategically planned health event consisting of various health promotion stalls, many developed by local villagers themselves. The organisation of the event was aided by resource mobilisation within the local community. Discussion: Social branding can be an effective tool for health promotion in community settings. Studying people’s cultural preferences and what makes them feel connected and excited can lay the foundations for the creation of a social brand that reflects their choices and helps them take up healthy behaviours on their own. It is possible to mobilise a community for health through social branding that is culturally relevant and connected to the interests and priorities of local people.