bluuebunny/crossref_metadata_2025_split huggingface dataset:
Draft Genome Sequence of
Streptomyces
sp. SPMA113, a Prajinamide Producer
Authors: Komaki Hisayuki , Hosoyama Akira , Ichikawa Natsuko , Panbangred Watanalai , Igarashi Yasuhiro 
Published: October 2016

ABSTRACT

We report here the draft genome sequence of
Streptomyces
sp. SPMA113 isolated from soil in Thailand. This strain produces a new modified peptide, prajinamide, which has adipocyte differentiation activity. The genome harbors at least 30 gene clusters for synthases of polyketide and nonribosomal peptide, suggesting its potential to produce diverse secondary metabolites.
Whole-Genome Sequence of Pseudomonas xanthomarina Strain UASWS0955, a Potential Biological Agent for Agricultural and Environmental Uses
Authors: Crovadore Julien , Cochard Bastien , Calmin Gautier , Chablais Romain , Schulz Torsten , Lefort François 
Published: October 2016

ABSTRACT

We report here the whole-genome shotgun sequence of the strain UASWS0955 of the species
Pseudomonas xanthomarina
, isolated from sewage sludge. This genome was obtained with an Illumina MiniSeq and is the second genome registered for this species, which is considered as a promising resource for agriculture and bioremediation of contaminated soils.
Whole-Genome Sequence of
Mesorhizobium hungaricum
sp. nov. Strain UASWS1009, a Potential Resource for Agricultural and Environmental Uses
Authors: Crovadore Julien , Cochard Bastien , Calmin Gautier , Chablais Romain , Schulz Torsten , Lefort François 
Published: October 2016

ABSTRACT

We report here the whole-genome shotgun sequences of the strain UASWS1009 of the species
Mesorhizobium hungaricum
sp. nov., which are different from any other known
Mesorhizobium
species. This is the first genome registered for this new species, which could be considered as a potential resource for agriculture and environmental uses.
Transverse spin observables in hard-scattering hadronic processes within collinear factorization
Authors: Pitonyak Daniel 
Published: October 2016

We review what is currently known about the transverse spin structure of hadrons, in particular from observables that can be analyzed within a collinear framework. These effects have been around for 40 years and represent a critical test of perturbative QCD. We look at both proton–proton and lepton–nucleon collisions for various final states. While the main focus is on transverse single-spin asymmetries, we also discuss how longitudinal-transverse double-spin asymmetries offer a complimentary, yet equally important, source of information on the quark–gluon content of hadrons. We also summarize some recent progress in solidifying the theoretical formalism behind these observables and give an outlook on future directions of research.
A note on applications of the d-invariant and Donaldson's theorem
Authors: Greene Joshua Evan 
Published: October 2016

This paper contains two remarks about the application of the [Formula: see text]-invariant in Heegaard Floer homology and Donaldson's diagonalization theorem to knot theory. The first is the equivalence of two obstructions they give to a 2-bridge knot being smoothly slice. The second carries out a suggestion by Stefan Friedl to replace the use of Heegaard Floer homology by Donaldson's theorem in the proof of the main result of [J. E. Greene, Lattices, graphs, and Conway mutation, Invent. Math. 192(3) (2013) 717–750] concerning Conway mutation of alternating links.
Quantitative characterization of the excavation damaged zone fracture network in the Meuse/Haute-Marne Underground Research Laboratory:
in situ
experiment and numerical interpretation of helium injection test
Authors: Shao Hua , Göthling Sebastian , Liu Wenting , Hesser Jürgen , Morel Jacques , Sönnke Jürgen 
Published: October 2016

Abstract
In the underground laboratory of Meuse/Haute-Marne (Bure) in France, different fracture types have been intensively investigated. Within a co-operative project between BGR and ANDRA, geophysical measurements and borehole gas tests were conducted in three well-designed boreholes in the gallery GRM to characterize the fracture structure and to determine the gas tracer velocity within fracture networks.
On the basis of seismic measurements and nitrogen gas interference tests, helium was injected into an interval of borehole OHZ3003, where an unloading joint has been identified. The injection took place in the form of a 10 min ‘pulse’ with an injection pressure of 2 bar. The other two boreholes, OHZ3002, where an upper part of the shear-mode fractures (‘chevron’ pattern) dominate, and OHZ3001, where shear-mode fractures (subvertical ‘oblique’ fractures and ‘chevron’ pattern) exist, served as observation holes. To maintain the pressure gradient between the injection hole and the observation holes, nitrogen gas was subsequently flushed into the injection hole. Two breakthrough curves of helium concentration and pressure developments in the two observation holes were continuously monitored using two helium leakage detectors and pressure gauges.
To interpret the measured pressure and concentration data, numerical models were constructed. A 3D model was used to simulate nitrogen gas flow and 2D models were applied to simulate a helium transport process. The real volume of the injection interval was considered in the model and the experimental process was simulated. Using the calibrated transport parameter data for a helium tracer from previous studies in the Mont Terri Rock Laboratory, the calculated breakthrough curves agreed well with those obtained from measuring the variation in permeability. The permeability derived from the helium tracer test agrees well with the estimation obtained from the nitrogen gas tests.
Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats
Authors: Li Peng , Huang Pei-Pei , Yang Yun , Liu Chi , Lu Yan , Wang Fang , Sun Wei , Kong Xiang-Qing 
Published: October 2016

Li P, Huang P, Yang Y, Liu C, Lu Y, Wang F, Sun W, Kong X. Renal sympathetic denervation attenuates hypertension and vascular remodeling in renovascular hypertensive rats. J Appl Physiol 122: 121–129, 2017. First published October 14, 2016; doi: 10.1152/japplphysiol.01019.2015 .—Sympathetic activity is enhanced in patients with essential or secondary hypertension, as well as in various hypertensive animal models. Therapeutic targeting of sympathetic activation is considered an effective antihypertensive strategy. We hypothesized that renal sympathetic denervation (RSD) attenuates hypertension and improves vascular remodeling and renal disease in the 2-kidney, 1-clip (2K1C) rat model. Rats underwent 2K1C modeling or sham surgery; then rats underwent RSD or sham surgery 4 wk later, thus resulting in four groups (normotensive-sham, normotensive-RSD, 2K1C-sham, and 2K1C-RSD). Norepinephrine was measured by ELISA. Echocardiography was used to assess heart function. Fibrosis and apoptosis were assessed by Masson and TUNEL staining. Changes in mean arterial blood pressure in response to hexamethonium and plasma norepinephrine levels were used to evaluate basal sympathetic nerve activity. The 2K1C modeling success rate was 86.8%. RSD reversed the elevated systolic blood pressure induced by 2K1C, but had no effect on body weight. Compared with rats in the 2K1C-sham group, rats in the 2K1C-RSD group showed lower left ventricular mass/body weight ratio, interventricular septal thickness in diastole, left ventricular end-systolic diameter, and left ventricular posterior wall thickness in systole, whereas fractional shortening and ejection fraction were higher. Right kidney apoptosis and left kidney hypertrophy were not changed by RSD. Arterial fibrosis was lower in animals in the 2K1C-RSD group compared with those in the 2K1C-sham group. RSD reduced plasma norepinephrine and basal sympathetic activity in rats in the 2K1C-RSD group compared with rats in the 2K1C-sham group. These results suggest a possible clinical efficacy of RSD for renovascular hypertension. NEW & NOTEWORTHY The effects of renal sympathetic denervation (RSD) on hypertension, cardiac function, vascular fibrosis, and renal apoptosis were studied in the 2K1C rat model. Results showed that RSD attenuated hypertension, improved vascular remodeling, and reduced vascular fibrosis through decreased sympathetic activity in the 2K1C rat model, but it did not change the kidney size, renal apoptosis, or renal caspase-3 expression. These results could suggest possible clinical efficacy of RSD for renovascular hypertension.
Translational Diagnostics and Therapeutics in Pancreatic Neuroendocrine Tumors
Authors: Maxwell Jessica E. , Sherman Scott K. , Howe James R. 
Published: October 2016

Abstract
Pancreatic neuroendocrine tumors (PNET) are rare tumors, but have been increasing in incidence. Although typically thought of as indolent, more than half of patients present with metastatic disease. For many years, the only mutations commonly known in these tumors were those in the MEN1 gene. Recently, the genetics underlying PNETs have been further defined through exome sequencing. The most frequent alterations found in sporadic PNETs are in MEN1, DAXX/ATRX, and a variety of genes in the mTOR pathway. Confirmation of these mutations has prompted trials with a number of drugs active in these pathways, and two drugs were eventually approved in 2011—sunitinib and everolimus. New data additionally identify the MET and CD47 receptors as potential novel drug targets. Yet despite improvements in progression-free survival with sunitinib and everolimus, further studies defining when to use these agents and factors associated with limitations in their utility are needed. As more discoveries are made in the laboratory that elucidate additional molecular mechanisms important in the initiation and metastasis of PNETs, continued efforts to translate these discoveries into distinct new therapies will be needed to improve patient survival. Clin Cancer Res; 22(20); 5022–9. ©2016 AACR.
See all articles in this CCR Focus section, “Endocrine Cancers: Revising Paradigms.”
New View on Endothelial Cell Migration
Authors: Kick Kerstin , Nekolla Katharina , Rehberg Markus , Vollmar Angelika M. , Zahler Stefan 
Published: October 2016

Objective—
Cell–matrix interactions are crucial for regulating cellular activities, such as migration. This is of special importance for morphogenic processes, such as angiogenesis (the development of new blood vessels). Most of our understanding of cell migration relies on 2-dimensional (2D) experiments. However, the awareness that 3D settings might elicit different results has increased. Knowledge about endothelial cell (EC) behavior in 3D environments and the influence of matrix composition on EC migration, in particular, is still limited.

Approach and Results—
We characterize the migration of single ECs through 2 structurally different hydrogels: spongy Matrigel and fibrillar collagen I. Our observations reveal an elongated migration phenotype in Matrigel and a rounded phenotype with pronounced cell blebs (blebs >2 µm) in collagen I, which have not previously been described in ECs. Directed migration seems to depend on Rac1 and Cdc42 in collagen, but not in Matrigel (shown using appropriate pharmacological inhibitors). By applying anti-integrin antibodies and supplementing laminin in collagen gels, we identify laminin as the main determinant of the elongated phenotype. Laminin seems to induce a morphological switch between modes of migration. As an in situ proof of principle, we performed live imaging of EC migration during vascular growth in a murine retina in the absence and presence of anti-integrin antibodies.

Conclusions—
We show that, surprisingly, ECs can evade the pharmacological inhibition of central signaling pathways involved in migration (contractility, small GTPases, and proteolysis) by shifting gears between modes of migration. This finding indicates an unexpected contextual plasticity of EC behavior.
Age and Cardiovascular Risk Attributable to Apolipoprotein B, Low‐Density Lipoprotein Cholesterol or Non‐High‐Density Lipoprotein Cholesterol
Authors: Sniderman Allan D. , Islam Shofiqul , McQueen Matthew , Pencina Michael , Furberg Curt D. , Thanassoulis George , Yusuf Salim 
Published: October 2016

Background
Higher concentrations of the apolipoprotein B (apoB) lipoproteins increase the risk of cardiovascular disease. However, whether the risk associated with apoB lipoproteins varies with age has not been well examined.

Methods and Results

We determined the associations for total cholesterol, low‐density lipoprotein (
LDL
)‐cholesterol (
LDL
‐C), non‐high‐density lipoprotein‐cholesterol (non‐
HDL
‐C), apoB, apolipoprotein A‐I (apoA‐I), and
HDL
‐cholesterol (
HDL
‐C) with myocardial infarction at different ages in 11 760 controls and 8998 myocardial infarction cases of the
INTERHEART
Study. Logistic regression was used to compute the odds ratio of myocardial infarction for 1 SD change in each lipid marker by decade from <40 to >70 years of age. Except for those >70, plasma levels of total cholesterol,
LDL
‐C, and non‐
HDL
‐C and apoB were greater in cases than controls. However, the average levels of these markers decreased significantly as age increased. By contrast, levels of apoA‐I and
HDL
‐C were significantly greater in controls than cases but increased significantly as age increased. The cardiovascular risk associated with the atherogenic lipid markers differed at different ages. Most notably, there was a significant decline in the odds ratio for total cholesterol,
LDL
‐C, and non‐
HDL
‐C, and apoB with increases in age whereas the odds ratios associated with apoA‐I and
HDL
‐C were consistent across the age groups.

Conclusions

These data indicate that the risk of cardiovascular events associated with apoB particles is greater in younger compared to older individuals. This finding is consistent with greater relative benefit from
LDL
‐lowering therapy in younger compared to older individuals and so argues for therapy in younger individuals with elevated lipids.
Short Time Interval Between Neurologic Event and Carotid Surgery Is Not Associated With an Increased Procedural Risk
Authors: Tsantilas Pavlos , Kuehnl Andreas , König Thomas , Breitkreuz Thorben , Kallmayer Michael , Knappich Christoph , Schmid Sofie , Storck Martin , Zimmermann Alexander , Eckstein Hans-Henning 
Published: October 2016

Background and Purpose—
Guidelines recommend that carotid endarterectomy should be performed within 2 weeks in patients with a symptomatic carotid stenosis. Because a Swedish register study indicated that patients treated within the first days after a stroke or transient ischemic attack might have an increased perioperative stroke and mortality risk, this study aimed to find out whether these findings are also true under everyday conditions in Germany.

Methods—
Secondary data analysis including 56 336 elective carotid endarterectomy procedures performed for symptomatic carotid stenosis under everyday conditions between 2009 and 2014. The patient cohort was divided into 4 groups according to time interval between index event and surgery (I: 0–2, II: 3–7, III: 8–14, and IV: 14–180 days). Primary outcome was any in-hospital stroke or death. For risk-adjusted analyses, a multilevel multivariable regression model was used.

Results—
Mean patients’ age was 71.1±9.6 years; 67.5% were men. Overall rate of any stroke or death was 2.5% (n=1434). Risk of any in-hospital stroke or death was 3.0% in group I, 2.5% in group II, 2.6% in group III, and 2.3% in group IV. Multivariable regression analysis revealed that the time interval was not significantly associated with the primary outcome.

Conclusions—
The time interval between the index event and carotid endarterectomy was not associated with the risk of any in-hospital stroke or death in patients with symptomatic carotid stenosis in Germany. In clinically stable patients, carotid endarterectomy might, therefore, be performed safely as soon as possible after the neurological index event.
Modeling Solar Irradiance and Solar PV Power Output to Create a Resource Assessment Using Linear Multiple Multivariate Regression
Authors: Clack Christopher T. M. 
Published: October 2016

AbstractThe increased use of solar photovoltaic (PV) cells as energy sources on electric grids has created the need for more accessible solar irradiance and power production estimates for use in power modeling software. In the present paper, a novel technique for creating solar irradiance estimates is introduced. A solar PV resource dataset created by combining numerical weather prediction assimilation model variables, satellite data, and high-resolution ground-based measurements is also presented. The dataset contains ≈152 000 geographic locations each with ≈26 000 hourly time steps. The solar irradiance outputs are global horizontal irradiance (GHI), direct normal irradiance (DNI), and diffuse horizontal irradiance (DIF). The technique is developed over the United States by training a linear multiple multivariate regression scheme at 10 locations. The technique is then applied to independent locations over the whole geographic domain. The irradiance estimates are input into a solar PV power modeling algorithm to compute solar PV power estimates for every 13-km grid cell. The dataset is analyzed to predict the capacity factors for solar resource sites around the United States for 2006–08. Statistics are shown to validate the skill of the scheme at geographic sites independent of the training set. In addition, it is shown that more high-quality, geographically dispersed, observation sites increase the skill of the scheme.
Minimum Required Attention: A Human-Centered Approach to Driver Inattention
Authors: Kircher Katja , Ahlstrom Christer 
Published: October 2016

Objective: To propose a driver attention theory based on the notion of driving as a satisficing and partially self-paced task and, within this framework, present a definition for driver inattention. Background: Many definitions of driver inattention and distraction have been proposed, but they are difficult to operationalize, and they are either unreasonably strict and inflexible or suffer from hindsight bias. Method: Existing definitions of driver distraction are reviewed and their shortcomings identified. We then present the minimum required attention (MiRA) theory to overcome these shortcomings. Suggestions on how to operationalize MiRA are also presented. Results: MiRA describes which role the attention of the driver plays in the shared “situation awareness of the traffic system.” A driver is considered attentive when sampling sufficient information to meet the demands of the system, namely, that he or she fulfills the preconditions to be able to form and maintain a good enough mental representation of the situation. A driver should only be considered inattentive when information sampling is not sufficient, regardless of whether the driver is concurrently executing an additional task or not. Conclusions: The MiRA theory builds on well-established driver attention theories. It goes beyond available driver distraction definitions by first defining what a driver needs to be attentive to, being free from hindsight bias, and allowing the driver to adapt to the current demands of the traffic situation through satisficing and self-pacing. MiRA has the potential to provide the stepping stone for unbiased and operationalizable inattention detection and classification.
Properties and performances of fabrics made from bio-based and degradable polylactide acid/poly (hydroxybutyrate- co-hydroxyvalerate) (PLA/PHBV) filament yarns
Authors: Huang XX , Tao XM , Zhang ZH , Chen P 
Published: October 2016

This paper reports a comparative experimental study of single jersey knitted fabrics made from a novel bio-based and degradable polylactide acid/poly (hydroxybutyrate-co-hydroxyvalerate) (PLA/PHBV) multi-filament yarn, together with polylactide acid , Cupro, polyethylene terephthalate (PET) and polyamide 6 (PA 6) multi-filament yarns. Their structures, mechanical, thermal and surface properties and performances as well as anti-bacterial behavior are measured and compared. It has been found that the polylactide acid/poly (hydroxybutyrate-co-hydroxyvalerate) (PLA/PHBV) filament yarn has adequate thermal and mechanical properties for normal textile and coloration/finishing processes. The Young's modulus of polylactide acid/poly (hydroxybutyrate-co-hydroxyvalerate) (PLA/PHBV) multi-filament yarn is the lowest among all the candidates investigated except for polyamide 6 (PA 6). The dyed polylactide acid/poly (hydroxybutyrate-co-hydroxyvalerate) (PLA/PHBV) fabric has the highest softness rating among all the fabrics. Single jersey knitted fabrics from the polylactide acid/poly (hydroxybutyrate-co-hydroxyvalerate) (PLA/PHBV) filament yarn have a bursting strength, extension and recovery that satisfy the industrial requirement. In addition, after fully relaxation, the dyed polylactide acid/poly (hydroxybutyrate-co-hydroxyvalerate) (PLA/PHBV) knitted fabrics exhibit an outstanding pilling resistance, favorable snagging property, as well as good air permeability, Qmax and smoother surface. Finally, this study has led to a discovery of excellent anti-bacterial performance of 100% polylactide acid/poly (hydroxybutyrate-co-hydroxyvalerate) (PLA/PHBV) fabrics against staphylococcus aureus, klebsiella pneumoniae, candida albicans according to AATCC100-2012.
Generation of sclerosant foams by mechanical methods increases the foam temperature
Authors: Tan Lulu , Wong Kaichung , Connor David , Fakhim Babak , Behnia Masud , Parsi Kurosh 
Published: October 2016

Objective To investigate the effect of agitation on foam temperature. Methods Sodium tetradecyl sulphate and polidocanol were used. Prior to foam generation, the sclerosant and all constituent equipment were cooled to 4–25℃ and compared with cooling the sclerosant only. Foam was generated using a modified Tessari method. During foam agitation, the temperature change was measured using a thermocouple for 120 s. Results Pre-cooling all the constituent equipment resulted in a cooler foam in comparison with only cooling the sclerosant. A starting temperature of 4℃ produced average foam temperatures of 12.5 and 13.2℃ for sodium tetradecyl sulphate and polidocanol, respectively. It was also found that only cooling the liquid sclerosant provided minimal cooling to the final foam temperature, with the temperature 20 and 20.5℃ for sodium tetradecyl sulphate and polidocanol, respectively. Conclusion The foam generation process has a noticeable impact on final foam temperature and needs to be taken into consideration when creating foam.