bluuebunny/crossref_metadata_2025_split huggingface dataset:
Growth and Differentiation Factors
Authors: Metcalf† Donald 
Published: October 2016

ABSTRACTThis review is restricted to neutrophilic granulocytes (granulocytes), monocytes (macrophages), and eosinophils, with only passing reference to cells that are also usually included in the “myeloid” category—megakaryocytes, mast cells, and erythroid cells. Although some dendritic cells are of myeloid origin, they are discussed elsewhere. The validity of the information to be described depends on two assumptions: (a) thatin vitrodata are applicable to eventsin vivoand (b) that mouse data reflect events in man. Both assumptions are likely to be broadly correct.
Mechanisms of Myeloid Cell Modulation of Atherosclerosis
Authors: Swirski Filip K. , Nahrendorf Matthias , Libby Peter 
Published: October 2016

ABSTRACT
Inflammation furnishes a series of pathogenic pathways that couple the risk factors for atherosclerosis with altered behavior of the intrinsic cells of the arterial wall, endothelium, and smooth muscle and promote the disease and its complications. Myeloid cells participate critically in all phases of atherosclerosis from initiation through progression, and ultimately the thrombotic consequences of this disease. Foam cells, lipid-laden macrophages, constitute the hallmark of atheromata. Much of the recent expansion in knowledge of the roles of myeloid cells in atherosclerosis revolves around the functional contributions of subsets of monocytes, precursors of macrophages, the most abundant myeloid cells in the atheroma. Proinflammatory monocytes preferentially accumulate in nascent atherosclerotic plaques. The most dramatic manifestations of atherosclerosis result from blood clot formation. Myocardial infarction, ischemic stroke, and abrupt limb ischemia all arise primarily from thrombi that complicate atherosclerotic plaques. Myeloid cells contribute pivotally to triggering thrombosis, for example, by elaborating enzymes that degrade the plaque’s protective extracellular matrix, rendering it fragile, and by producing the potent procoagulant tissue factor. While most attention has focused on mononuclear phagocytes, the participation of polymorphonuclear leukocytes may aggravate local thrombus formation. Existing therapies such as statins may exert some of their protective effects by altering the functions of myeloid cells. The pathways of innate immunity that involve myeloid cells provide a myriad of potential targets for modifying atherosclerosis and its complications, and provide a fertile field for future attempts to address the residual burden of this disease, whose global prevalence is on the rise.
Role of the Cytoskeleton in Myeloid Cell Function
Authors: Fine Noah , Khaliq Samira , Hassanpour Siavash , Glogauer Michael 
Published: October 2016

ABSTRACTDuring an innate immune response, myeloid cells undergo complex morphological adaptations in response to inflammatory cues, which allow them to exit the vasculature, enter the tissues, and destroy invading pathogens. The actin and microtubule cytoskeletons are central to many of the most essential cellular functions including cell division, cell morphology, migration, intracellular trafficking, and signaling. Cytoskeletal structure and regulation are crucial for many myeloid cell functions, which require rapid and dynamic responses to extracellular signals. In this chapter, we review the roles of the actin and microtubule cytoskeletons in myeloid cells, focusing primarily on their roles in chemotaxis and phagocytosis. The role of myeloid cell cytoskeletal defects in hematological disorders is highlighted throughout.
Egg Safety in the Realm of Preharvest Food Safety
Authors: Singh Manpreet , Brar Jagpinder 
Published: October 2016

ABSTRACT
Eggs are nutritious, yet they are a highly perishable commodity like other protein sources such as meat. Even though steps are taken all along the production process of shell eggs, from farm to table, the potential for contamination of the shells and egg contents poses a high risk to consumers. The main sources of contamination can be categorized as vertical transmission, in which the layers can be carriers of pathogens and can pass them on during egg formation, and horizontal transmission, in which environmental factors such as water, feed, layer houses, and personnel are the main source of contamination. Ongoing preharvest practices might not be enough to completely eliminate pathogens from shell eggs; however, consistently following good practices along with proper handling during transportation and retail sale and by consumers can be significant in reducing the risk. This article discusses the various aspects of production practices, their potential for cross-contamination, and decontamination technologies for shell eggs.
Reducing Foodborne Pathogen Persistence and Transmission in Animal Production Environments: Challenges and Opportunities
Authors: Berry Elaine D. , Wells James E. 
Published: October 2016

ABSTRACT
Preharvest strategies to reduce zoonotic pathogens in food animals are important components of the farm-to-table food safety continuum. The problem is complex; there are multiple pathogens of concern, multiple animal species under different production and management systems, and a variety of sources of pathogens, including other livestock and domestic animals, wild animals and birds, insects, water, and feed. Preharvest food safety research has identified a number of intervention strategies, including probiotics, direct-fed microbials, competitive exclusion cultures, vaccines, and bacteriophages, in addition to factors that can impact pathogens on-farm, such as seasonality, production systems, diet, and dietary additives. Moreover, this work has revealed both challenges and opportunities for reducing pathogens in food animals. Animals that shed high levels of pathogens and predominant pathogen strains that exhibit long-term persistence appear to play significant roles in maintaining the prevalence of pathogens in animals and their production environment. Continued investigation and advancements in sequencing and other technologies are expected to reveal the mechanisms that result in super-shedding and persistence, in addition to increasing the prospects for selection of pathogen-resistant food animals and understanding of the microbial ecology of the gastrointestinal tract with regard to zoonotic pathogen colonization. It is likely that this continued research will reveal other challenges, which may further indicate potential targets or critical control points for pathogen reduction in livestock. Additional benefits of the preharvest reduction of pathogens in food animals are the reduction of produce, water, and environmental contamination, and thereby lower risk for human illnesses linked to these sources.
Emerging Foodborne and Agriculture-Related Viruses
Authors: Kingsley David H. 
Published: October 2016

ABSTRACT
Viruses rapidly evolve and can emerge in unpredictable ways. Transmission pathways by which foodborne viruses may enter human populations and evolutionary mechanisms by which viruses can become virulent are discussed in this chapter. A majority of viruses emerge from zoonotic animal reservoirs, often by adapting and infecting intermediate hosts, such as domestic animals and livestock. Viruses that are known foodborne threats include hepatitis E virus, tick-borne encephalitis virus, enteroviruses, adenovirus, and astroviruses, among others. Viruses may potentially evolve and emerge as a result of modern agricultural practices which can concentrate livestock and bring them into contact with wild animals. Examples of viruses that have emerged in this manner are influenza, coronaviruses such as severe acute respiratory syndrome and Middle East respiratory syndrome, and the Nipah virus. The role of bats, bush meat, rodents, pigs, cattle, and poultry as reservoirs from which infectious pathogenic viruses emerge are discussed.
Animal Models of Tuberculosis: An Overview
Authors: Williams Ann , Orme Ian M. 
Published: October 2016

ABSTRACTThis article provides an overview of the animal models currently used in tuberculosis research, both for understanding the basic science of the disease process and also for practical issues such as testing new vaccine candidates and evaluating the activity of potential new drugs. Animals range in size, from zebrafish to cattle, and in degrees of similarity to the human disease from both an immunological and pathologic perspective. These models have provided a great wealth of information (impossible to obtain simply from observing infected humans), but we emphasize here that one must use care in interpreting or applying this information, and indeed the true art of animal modeling is in deciding what is pertinent information and what might not be. These ideas are discussed in the context of current approaches in vaccine and drug development, including a discussion of certain limitations the field is currently facing in such studies.
The Evolutionary History, Demography, and Spread of the
Mycobacterium tuberculosis
Complex
Authors: Barbier Maxime , Wirth Thierry 
Published: October 2016

ABSTRACT

With the advent of next-generation sequencing technology, the genotyping of clinical
Mycobacterium tuberculosis
strains went through a major breakup that dramatically improved the field of molecular epidemiology but also revolutionized our deep understanding of the
M. tuberculosis
complex evolutionary history. The intricate paths of the pathogen and its human host are reflected by a common geographical origin in Africa and strong biogeographical associations that largely reflect the past migration waves out of Africa. This long coevolutionary history is cardinal for our understanding of the host-pathogen dynamic, including past and ongoing demographic components, strains’ genetic background, as well as the immune system genetic architecture of the host. Coalescent- and Bayesian-based analyses allowed us to reconstruct population size changes of
M. tuberculosis
through time, to date the most recent common ancestor and the several phylogenetic lineages. This information will ultimately help us to understand the spread of the Beijing lineage, the rise of multidrug-resistant sublineages, or the fall of others in the light of socioeconomic events, antibiotic programs, or host population densities. If we leave the present and go through the looking glass, thanks to our ability to handle small degraded molecules combined with targeted capture, paleomicrobiology covering the Pleistocene era will possibly unravel lineage replacements, dig out extinct ones, and eventually ask for major revisions of the current model.
DAMA/LIBRA–phase1 model independent results
Authors: Bernabei R. , Belli P. , d’Angelo S. , Di Marco A. , Montecchia F. , d’Angelo A. , Incicchitti A. , Prosperi D. , Cappella F. , Caracciolo V. , Cerulli R. , Dai C. J. , He H. L. , Kuang H. H. , Ma X. H. , Sheng X. D. , Wang R. G. , Ye Z. P. 
Published: October 2016

Experimental observations and theoretical arguments at Galaxy and larger scales have suggested that a large fraction of the Universe is composed by Dark Matter (DM) particles. This has motivated the DAMA experimental efforts to investigate the presence of such particles in the galactic halo by exploiting a model independent signature with highly radiopure setups deep underground. In this paper, a review of the results obtained with the total exposure of 1.04 ton × yr collected by DAMA/LIBRA–phase1 deep underground at the Gran Sasso National Laboratory (LNGS) of the INFN during seven annual cycles is given. The DAMA/LIBRA–phase1 data give evidence for the presence of DM particles in the galactic halo, on the basis of the exploited model independent DM annual modulation signature by using highly radiopure NaI(Tl) target, at 7.5[Formula: see text] C.L. Including also the data of the first generation DAMA/NaI experiment (cumulative exposure 1.33 ton × yr, corresponding to 14 annual cycles), the C.L. is 9.3[Formula: see text] and the modulation amplitude of the single-hit scintillation events in the (2–6) keV energy interval is: (0.0112 ± 0.0012) cpd/kg/keV; the measured phase is (144 ± 7) days and the measured period is (0.998 ± 0.002) yr, values well in agreement with those expected for DM particles. No systematic or side reaction able to mimic the exploited DM signature has been found or suggested by anyone over more than a decade.
Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy
Authors: Ingle James N. , Xie Fang , Ellis Matthew J. , Goss Paul E. , Shepherd Lois E. , Chapman Judith-Anne W. , Chen Bingshu E. , Kubo Michiaki , Furukawa Yoichi , Momozawa Yukihide , Stearns Vered , Pritchard Kathleen I. , Barman Poulami , Carlson Erin E. , Goetz Matthew P. , Weinshilboum Richard M. , Kalari Krishna R. , Wang Liewei 
Published: October 2016

AbstractGenetic risks in breast cancer remain only partly understood. Here, we report the results of a genome-wide association study of germline DNA from 4,658 women, including 252 women experiencing a breast cancer recurrence, who were entered on the MA.27 adjuvant trial comparing the aromatase inhibitors (AI) anastrozole and exemestane. Single-nucleotide polymorphisms (SNP) of top significance were identified in the gene encoding MIR2052HG, a long noncoding RNA of unknown function. Heterozygous or homozygous individuals for variant alleles exhibited a ∼40% or ∼63% decrease, respectively, in the hazard of breast cancer recurrence relative to homozygous wild-type individuals. Functional genomic studies in lymphoblastoid cell lines and ERα-positive breast cancer cell lines showed that expression from MIR2052HG and the ESR1 gene encoding estrogen receptor-α (ERα) was induced by estrogen and AI in a SNP-dependent manner. Variant SNP genotypes exhibited increased ERα binding to estrogen response elements, relative to wild-type genotypes, a pattern that was reversed by AI treatment. Further, variant SNPs were associated with lower expression of MIR2052HG and ERα. RNAi-mediated silencing of MIR2052HG in breast cancer cell lines decreased ERα expression, cell proliferation, and anchorage-independent colony formation. Mechanistic investigations revealed that MIR2052HG sustained ERα levels both by promoting AKT/FOXO3-mediated ESR1 transcription and by limiting ubiquitin-mediated, proteasome-dependent degradation of ERα. Taken together, our results define MIR2052HS as a functionally polymorphic gene that affects risks of breast cancer recurrence in women treated with AI. More broadly, our results offer a pharmacogenomic basis to understand differences in the response of breast cancer patients to AI therapy. Cancer Res; 76(23); 7012–23. ©2016 AACR.
Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth
Authors: Lin Huai-Peng , Cheng Zhou-Li , He Ruo-Yu , Song Lei , Tian Meng-Xin , Zhou Li-Sha , Groh Beezly S. , Liu Wei-Ren , Ji Min-Biao , Ding Chen , Shi Ying-Hong , Guan Kun-Liang , Ye Dan , Xiong Yue 
Published: October 2016

Abstract
Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacologic inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity, and other diseases. Here, we report a previously unknown mechanism of FASN regulation involving its acetylation by KAT8 and its deacetylation by HDAC3. FASN acetylation promoted its degradation via the ubiquitin–proteasome pathway. FASN acetylation enhanced its association with the E3 ubiquitin ligase TRIM21. Acetylation destabilized FASN and resulted in decreased de novo lipogenesis and tumor cell growth. FASN acetylation was frequently reduced in human hepatocellular carcinoma samples, which correlated with increased HDAC3 expression and FASN protein levels. Our results suggest opportunities to target FASN acetylation as an anticancer strategy. Cancer Res; 76(23); 6924–36. ©2016 AACR.
Early Life Residence, Fish Consumption, and Risk of Breast Cancer
Authors: Haraldsdottir Alfheidur , Steingrimsdottir Laufey , Valdimarsdottir Unnur A. , Aspelund Thor , Tryggvadottir Laufey , Harris Tamara B. , Launer Lenore J. , Mucci Lorelei A. , Giovannucci Edward L. , Adami Hans-Olov , Gudnason Vilmundur , Torfadottir Johanna E. 
Published: October 2016

Abstract
Background: Little is known about fish intake throughout the life course and the risk of breast cancer.
Methods: We used data on the first residence of 9,340 women born 1908 to 1935 in the Reykjavik Study as well as food frequency data for different periods of life from a subgroup of the cohort entering the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (n = 2,882).
Results: During a mean follow-up of 27.3 years, 744 women were diagnosed with breast cancer in the Reykjavik Study. An inverse association of breast cancer was observed among women who lived through the puberty period in coastal villages, compared with women residing in the capital area [HR, 0.78; 95% confidence interval (CI), 0.61–0.99]. In the subgroup analysis of this Icelandic population, generally characterized by high fish intake, we found an indication of lower risk of breast cancer among women with high fish consumption (more than 4 portions per week) in adolescence (HR, 0.71; 95% CI, 0.44–1.13) and midlife (HR, 0.46; 95% CI, 0.22–0.97), compared with low consumers (2 portions per week or less). No association was found for fish liver oil consumption in any time period, which could be due to lack of a reference group with low omega-3 fatty acids intake in the study group.
Conclusions: Our findings suggest that very high fish consumption in early to midlife may be associated with a reduced risk of breast cancer.
Impact: Very high fish consumption in early adulthood to midlife may be associated with decreased risk of breast cancer. Cancer Epidemiol Biomarkers Prev; 26(3); 346–54. ©2016 AACR.
A First-in-Human Phase I Study of a Bivalent MET Antibody, Emibetuzumab (LY2875358), as Monotherapy and in Combination with Erlotinib in Advanced Cancer
Authors: Rosen Lee S. , Goldman Jonathan W. , Algazi Alain P. , Turner P. Kellie , Moser Brian , Hu Tianle , Wang Xuejing Aimee , Tuttle Jay , Wacheck Volker , Wooldridge James E. , Banck Michaela 
Published: October 2016

Abstract
Purpose: The MET/HGF pathway regulates cell proliferation and survival and is dysregulated in multiple tumors. Emibetuzumab (LY2875358) is a bivalent antibody that inhibits HGF-dependent and HGF-independent MET signaling. Here, we report dose escalation results from the first-in-human phase I trial of emibetuzumab.
Experimental Design: The study comprised a 3+3 dose escalation for emibetuzumab monotherapy (Part A) and in combination with erlotinib (Part A2). Emibetuzumab was administered i.v. every 2 weeks (Q2W) using a flat dosing scheme. The primary objective was to determine a recommended phase II dose (RPTD) range; secondary endpoints included tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity.
Results: Twenty-three patients with solid tumors received emibetuzumab monotherapy at 20, 70, 210, 700, 1,400, and 2,000 mg and 14 non–small cell lung cancer (NSCLC) patients at 700, 1,400, and 2,000 mg in combination with erlotinib 150 mg daily. No dose-limiting toxicities and related serious or ≥ grade 3 adverse events were observed. The most common emibetuzumab-related adverse events included mild diarrhea, nausea, and vomiting, and mild to moderate fatigue, anorexia, and hypocalcemia in combination with erlotinib. Emibetuzumab showed linear PK at doses &gt;210 mg. Three durable partial responses were observed, one for emibetuzumab (700 mg) and two for emibetuzumab + erlotinib (700 mg and 2,000 mg). Both of the responders to emibetuzumab + erlotinib had progressed to prior erlotinib and were positive for MET protein tumor expression.
Conclusions: Based on tolerability, PK/PD analysis, and preliminary clinical activity, the RPTD range for emibetuzumab single agent and in combination with erlotinib is 700 to 2,000 mg i.v. Q2W. Clin Cancer Res; 23(8); 1910–9. ©2016 AACR.
Design and Fabrication of Rectifying Antenna Circuit for Wireless Power Transmission System Operating At ISM Band
Authors: Doan Chuc Huu , Bach Duong Gia 
Published: October 2016

This paper introduces an overview of a rectifying antenna (rectenna) circuit topology for microwave power transmission system. Specially, a rectenna based on a microstrip patch antenna and a microwave double voltage rectifier at 2.45GHz were designed and fabricated. The antenna’s return loss is achieved of -15 dB at 2.45GHz. The microwave to DC conversion efficiency of the rectenna was measured as 71.5% with 22 dBm input power and 810 Ohm load. The design and simulated results were carried out by the microwave engineering professional design software, known as ADS2009 package. All design and simulation results will be reported.
Comparative Study on the AC Brekadown Voltage of Palm Fatty Acid Ester Insulation Oils Mixed With Iron Oxide Nanoparticles
Authors: Mohamad Mohd Safwan , Zainuddin Hidayat , Ab Ghani Sharin , Chairul Imran Sutan 
Published: October 2016

Mineral oils are are derived from petroleum which is a non-renewable and non-sustainable source, and therefore there is a critical need to develop alternative insulation oils for use in transformers. Ester oils offer a number of benefits over mineral oils such as good biodegradability, high cooling stability, good oxidation stability and excellent insulation performance. Nowadays, nanotechnology has become one of the most important research fields in both the academia and industry and it has been shown in previous studies that nanoscale materials are beneficial for transformers. In this regard, the objective of this study is to compare the AC breakdown voltage of palm fatty acid ester (PFAE) oils mixed with iron oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles. The PFAE-based nanofluids are prepared using two methods: (1) Method I (weight-based method whereby the concentration of the Fe<sub>3</sub>O<sub>4 </sub>nanoparticles is 0.01 g/l) and (2) Method II (volume-fraction method whereby the concentration of the Fe<sub>3</sub>O<sub>4 </sub>nanoparticles is 0.01, 0.02 and 0.03%). The AC breakdown voltage test is conducted on the PFAE-based nanofluids in accordance with the ASTM D1816 standard test method. Weibull statistical analysis is carried out to analyse the AC breakdown voltage of fresh PFAE oil and PFAE-based nanofluids. It is found that there is enhancement of the AC breakdown voltage for all PFAE-based nanofluids with the exception of with the exception of one sample prepared using Method II (0.01% Fe<sub>3</sub>O<sub>4 </sub>nanoparticles).
Performance Analysis of Preemptive Based Uniprocessor Scheduling
Authors: Shanmugasundaram M , Kumar R , M Kittur Harish 
Published: October 2016

All the real-time systems are bound with response time constraints, or else, there is a risk of severe consequences, which includes failure. The System will fail when not able to meet the requirements according to the specifications. The problem of real-time scheduling is very vast, ranging from uni-processor to complicated-multiprocessor. In this paper, we have compared the performance of real-time tasks that should be scheduled properly, to get optimum performance. Analysis methodology and the concept of optimization leads to the design of appropriate scheduling. We have done the analysis among RM and EDF algorithm that are important for scheduling in uni-processor.