bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variations in Infant CYP2B6 Genotype Associated with the Need for Pharmacological Treatment for Neonatal Abstinence Syndrome in Infants of Methadone-Maintained Opioid-Dependent Mothers
Authors: McLaughlin Poppy , Gillis Cheryl , Osselton Michael , Mactier Helen 
Published: March 2017

Background Neonatal abstinence syndrome (NAS) in infants of methadone-maintained opioid-dependent (MMOD) mothers cannot be predicted in individual cases. We investigated whether variation in infant genotype is associated with severity of NAS.
Methods This is a pilot observational cohort study of 21 MMOD mothers and their newborns. Infant buccal swabs were obtained soon after delivery, together with a maternal blood sample for the determination of maternal plasma methadone concentration. Genomic variation in five opioid-related genes (ABCB1, COMT, CYP2B6, CYP2D6, and OPRM1) was ascertained from infant buccal swabs and related to need for pharmacological treatment of NAS.
Results Out of 21 infants, 11 (52%) required treatment for NAS. Mothers of treated infants tended to have been prescribed higher doses of methadone, but plasma methadone concentrations did not differ between mothers of treated or untreated babies. Treated and untreated babies did not differ in terms of method of feeding. Treated infants were more likely to carry the normal (homozygous) allele at 516 and 785 regions of CYP2B6 gene (p = 0.015 and 0.023, respectively). There were no differences in any other genes between infants who did or did not require treatment for NAS.
Conclusion Genomic variation in CYP2B6 may explain, at least in part, severity of NAS.
Redefinition of Atypical Parkinsonian Syndromes
Authors: Respondek G. , Levin J. , Höglinger G. 
Published: March 2017

AbstractThe definition of atypical parkinsonian syndromes is undergoing a change. The umbrella concept of atypical parkinsonian syndromes includes diseases with different underlying pathologies. These are, on the one hand, multiple system atrophy (MSA) and dementia with Lewy bodies (DLB), both of which are characterized by intracellular aggregates of the protein alpha-synuclein, and on the other hand, corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP), which are characterized by aggregates of the protein tau. The current syndrome-based classification of these diseases no longer meets current requirements since 1) numerous clinico-pathological studies have shown that the clinical syndromes do not always coincide with the molecular-pathological diagnosis, 2) a clinical parkinsonian syndrome is sometimes not even present in patients with a pathological diagnosis of an atypical parkinsonian syndrome, and 3) current therapeutic trials that intervene in the molecular disease mechanisms require no symptom-oriented, but a pathogenetically oriented diagnosis. The early and correct prediction of the underlying molecular pathology as a prerequisite for a causative therapy therefore presents a challenge that the old disease concept is no longer capable of meeting.
Cardiac Arrhythmia following Stroke
Authors: Kallmünzer Bernd , Schwab Stefan 
Published: March 2017

AbstractOne in 4 patients with acute stroke suffers from clinically relevant cardiac arrhythmia that may complicate the clinical course by hemodynamic instability, limit the success of rehabilitative care and increase the risk of stroke recurrence. A structured analysis of the continuous ECG recordings at the stroke unit can double the detection rate of paroxysmal atrial fibrillation compared to conventional monitoring. In case of suspected cardiac arrhythmia, ambulatory long-term heart rhythm monitoring is available for patients with stroke of unknown cause. Apart from the emergency management of arrhythmia, different aspects of the antithrombotic treatment for secondary prevention are of major therapeutic relevance and represent clinical challenges for the neurologist.
A Shakespeare of one’s own: female users of playbooks from the seventeenth to the mid-eighteenth century
Authors: Sae Kitamura 
Published: March 2017

AbstractThe aim of this article is to understand women’s intellectual activities involving Shakespeare’s playbooks by analysing their various book-related activities, such as annotating, editing, signing and attaching ex libris to books. Although researchers have increasingly recognized women’s participation in the canonization of Shakespeare, ex libris and book users’ signatures, unlike other resources, have not been systematically studied in relation to gender. Discreet observations and evaluations, typified by reading, are rarely appreciated as a participatory or creative process. However, it is hoped that this study focusing on women’s use of Shakespeare’s playbooks will give a voice to these seemingly quiet interpreters. For primary sources, more than 800 pre-1769 copies of Shakespeare’s playbooks held in major libraries throughout the world, including the British Library and Folger Shakespeare Library, were consulted. This research shows that women were actively involved in book-related activities; for example, they exchanged Shakespeare’s playbooks as gifts and preserved rare copies as family treasures. Some female readers even annotated Shakespeare’s works earlier than believed, approximately 40 years before the publication of Harriet Bowdler’s The Family Shakespeare in 1807. This article is published as part of a collection to commemorate the 400th anniversary of Shakespeare’s death.
Inequalities and monotonicity results for zeros of modified Bessel functions of purely imaginary order
Authors: Laforgia Andrea 
Published: March 2017

Let

x
k

(
v
)

{x_k}\left ( v \right )

and

x
k
′

(
v
)

{x’_k}\left ( v \right )

denote the

k
k

th positive zeros, in decreasing order, of the modified Bessel function

K

i
v

(
x
)

{K_{iv}}\left ( x \right )

of purely imaginary order and of its derivative

K

i
v

′

(
x
)

=

d

d
x

K

i
v

(
x
)

{K’_{iv}}\left ( x \right ) = {\textstyle {d \over {dx}}}{K_{iv}}\left ( x \right )

, respectively. We show that for

k
=
1
,
2
,
.
.
.

k = 1,2,...

and

0
>
v
>
∞
,

x
k

(
v
)

>

x
k
′

(
v
)

>
v

0 > v > \infty ,{x_k}\left ( v \right ) > {x’_k}\left ( v \right ) > v

and

x
k

(
v
)

/

x

k
+
1

(
v
)

{x_k}\left ( v \right )/{x_{k + 1}}\left ( v \right )

and

x
k

(
v
)

−

x

k
+
1

(
v
)

{x_k}\left ( v \right ) - {x_{k + 1}}\left ( v \right )

decrease as

k
k

increases. Some related results are mentioned for the zeros of

K

i
v

′

(
x
)

{K’_{iv}}\left ( x \right )

and the chain of inequalities

|

K

i
v

(

x
′

1

(
v
)

)

|

>

|

K

i
v

(

x
′

2

(
v
)

)

|

>
⋅
⋅
⋅
>

|

K

i
v

(

x
′

n

(
v
)

)

|

>

|

K

i
v

(

x
′

n
+
1

(
v
)

)

|

>
⋅
⋅
⋅

\left | {{K_{iv}}\left ( {{{x’}_1}\left ( v \right )} \right )} \right | > \left | {{K_{iv}}\left ( {{{x’}_2}\left ( v \right )} \right )} \right | > \cdot \cdot \cdot > \left | {{K_{iv}}\left ( {{{x’}_n}\left ( v \right )} \right )} \right | > \left | {{K_{iv}}\left ( {{{x’}_{n + 1}}\left ( v \right )} \right )} \right | > \cdot \cdot \cdot

is established.
ViPTree: the viral proteomic tree server
Authors: Nishimura Yosuke , Yoshida Takashi , Kuronishi Megumi , Uehara Hideya , Ogata Hiroyuki , Goto Susumu 
Published: March 2017

Abstract

Summary
ViPTree is a web server provided through GenomeNet to generate viral proteomic trees for classification of viruses based on genome-wide similarities. Users can upload viral genomes sequenced either by genomics or metagenomics. ViPTree generates proteomic trees for the uploaded genomes together with flexibly selected reference viral genomes. ViPTree also serves as a platform to visually investigate genomic alignments and automatically annotated gene functions for the uploaded viral genomes, thus providing virus researchers the first choice for classifying and understanding newly sequenced viral genomes.

Availability and Implementation
ViPTree is freely available at: http://www.genome.jp/viptree.

Supplementary information
Supplementary data are available at Bioinformatics online.
CImbinator: a web-based tool for drug synergy analysis in small- and large-scale datasets
Authors: Flobak Åsmund , Vazquez Miguel , Lægreid Astrid , Valencia Alfonso 
Published: March 2017

Abstract

Motivation
Drug synergies are sought to identify combinations of drugs particularly beneficial. User-friendly software solutions that can assist analysis of large-scale datasets are required.

Results
CImbinator is a web-service that can aid in batch-wise and in-depth analyzes of data from small-scale and large-scale drug combination screens. CImbinator offers to quantify drug combination effects, using both the commonly employed median effect equation, as well as advanced experimental mathematical models describing dose response relationships.

Availability and Implementation
CImbinator is written in Ruby and R. It uses the R package drc for advanced drug response modeling. CImbinator is available at http://cimbinator.bioinfo.cnio.es, the source-code is open and available at https://github.com/Rbbt-Workflows/combination_index. A Docker image is also available at https://hub.docker.com/r/mikisvaz/rbbt-ci_mbinator/.

Supplementary information
Supplementary data are available at Bioinformatics online.
Passive leg raising for assessment of volume responsiveness: a review
Authors: Mesquida Jaume , Gruartmoner Guillem , Ferrer Ricard 
Published: March 2017

Purpose of review
To evaluate the existing evidence on the passive leg raising (PLR) test for fluid responsiveness prediction.

Recent findings
It has been well established that either insufficient or excessive fluid administration derives in worse outcomes in critically ill patients, highlighting that a more accurate assessment of fluid management is required. Accordingly, several cardiovascular indices have been tested to improve our ability to predict patients’ response to fluid loading at the bedside, the so-called functional hemodynamic monitoring. The standardized PLR is a relatively novel maneuver that, over the past 10 years, has repeatedly demonstrated high sensitivity and specificity for fluid responsiveness prediction.

Summary
The current review underlines that PLR is an easy-to-perform and reliable method to assess fluid responsiveness. Its excellent performance is maintained even in many situations in which other dynamic predictive indices are not consistent and represents a valid alternative to the fluid challenge to avoid unnecessary volume administration.
Importance of intrinsic and extrinsic quality food characteristics by different consumer segments
Authors: Brečić Ruzica , Mesić Željka , Cerjak Marija 
Published: March 2017

Purpose
The purpose of this paper is to examine intrinsic and extrinsic food quality characteristics and the relative importance placed on these characteristics by different consumer segments. Moreover, relationship between segments of consumers and consumption frequency of differentiated food products (traditional, functional and organic) was analysed.

Design/methodology/approach
A three-stage stratified random sampling approach was employed and data were collected via 500 face-to-face interviews conducted in respondents’ homes. A version of the Food Choice Questionnaire was used to examine the motives of consumers’ underlying food choices. The collected data were analysed by factor analysis followed by cluster analysis.

Findings
Four factors were identified: health and sensory characteristics, price and availability, body weight and digestion, and convenience. Resulting clusters were named as: healthy and tasty food lovers, convenient, concerned, and indifferent consumers. Differences were identified between the segments according to consumers’ frequency of consumption of the different types of food products.

Practical implications
The findings have impact implications for food producers and distributors in developing communication strategies for consumer segments with different attitudes and motives. The findings of this study not only contribute to the organic, traditional, and food with health claim literature, but also help industry, government, and consumer associations fully understand consumer perceptions of intrinsic and extrinsic foods characteristics and enhance consumers’ responses to the different types of food products.

Originality/value
The study represents one of the first assessments of the importance of food quality characteristics, segmentation, and consumption frequency of traditional, organic, and functional food products in Central and Eastern Europe.
A comprehensive approach to pistachio oil production
Authors: Rabadán Adrián , Álvarez-Ortí Manuel , Pardo José E. , Gómez Ricardo , Pardo-Giménez Arturo , Olmeda Miguel 
Published: March 2017

Purpose
The high content of unsaturated fatty acids and the elevated presence of bioactive compounds make pistachio oil a healthy product with great commercial potential. One of the primary constraints for its production is the lack of information regarding oil extraction from an industrial perspective. The purpose of this paper is to ensure the success of pistachio oil production at a commercial scale, attention should be paid to the effect of the main extraction procedures on the characteristics of oil, the consumer acceptance of these oils and their production cost.

Design/methodology/approach
Comparison and evaluation of the physicochemical and sensory characteristics and production cost of oil extracted using two different production lines (hydraulic press and screw press) are considered here.

Findings
Slight differences were found in the physicochemical analysis, but significant differences were identified in the sensory analysis. Consumer judges preferred the oil extracted with the hydraulic press. According to production costs, the break-even value that makes screw press extraction sustainable is €70.4 per litre, while for the hydraulic press it is €91.0 per litre, mainly due to a lower extraction yield and the longer extraction time required. As production costs of both methods are high, pistachio oil quality should prevail, making the use of the hydraulic press more advisable.

Originality/value
Although significant research has been conducted to analyse pistachio oil composition and nutritional value, little attention has been paid to differences that appear regarding consumer preferences and production costs depending on the production method used. This paper provides a comprehensive approach to high-quality pistachio oil production from an industrial perspective.
Approaches to and the management of the audit process in the food industry
Authors: Bradford-Knox Richard 
Published: March 2017

Purpose
The purpose of this paper is to identify the purpose of food safety auditing, effectiveness in maintaining and improving standards of food safety and ways to improve the process.

Design/methodology/approach
Using a grounded approach semi-structured interviews were held with actors with experience of food safety auditing. The aims and objectives being to obtain their viewpoints drawn from their experience.

Findings
The purpose of food safety audits should be regarded as one of continuous improvement rather than a single snapshot or policing exercise. Audits in terms of cost can be excessive because of the often high number and frequency of them. Costs can be reduced and food safety standards maintained if the number and frequency of audits is determined by the level of hazard and risk that a product or a process presents. Effectiveness of audits can also be improved if they are unannounced to make businesses “audit ready” at all times. It is also contended that unannounced audits are not applicable in all circumstances as they can increase costs by the need to maintain a group of personnel that are always available for audits.

Research limitations/implications
The research is limited by the scope and number of topics that were addressed in relation to the main subject.

Originality/value
The research value points to a need to review and better manage the audit process by risk assessing the number, frequency and type of audit a food business is subject to without lowering standards.
Food safety compliance approaches
Authors: Bradford-Knox Richard , Neighbour Simon 
Published: March 2017

Purpose
This case study follows the history of the personal and experiences, viewpoints, and attitudes of the key actors from both parties over the period of setting up and implementing a primary authority partnership. It is one of a series research papers and case studies that study approaches to improve compliance with public and private regulations through cooperative and collaborative approaches. The paper aims to discuss these issues.

Design/methodology/approach
It is a grounded qualitative study of what a number of individuals said in the course of a number of interviews. The aim and objectives being to obtain, from the key actors, their personal viewpoints, attitudes to and experiences of the partnership. Unlike some grounded approaches the research was based on the priori themes of cooperation and collaboration using semi structured interviews. At one stage, because of difficulty of access to the key actors caused by major re-development of the company, questionnaires replaced interviews.

Findings
The authors found that barriers to achieving a successful partnership included an initial reluctance, by all parties concerned, to cede some of their management autonomy to others and experiences of uncooperative behaviour between the public and private sectors in the past. They were largely overcome as the implementation of the project progressed resulting in improved food safety compliance management based on mutual trust. Other benefits for Preston City Council were immediate cost savings for Preston City Council in their use of human resources. For E.H. Booths, Ltd no initial cost saving was made, but there is potential longer term savings to be made through better risk based targeting of resources. These benefits only being made possible by the collaborative effort and support from all parties and individuals involved.

Originality/value
On its own this case study research is limited by its size and scope but the emerging topics and findings highlight the difficulties and barriers faced in setting up partnerships between public regulators and businesses. Therefore, the results can be of value to similar studies and other areas where cooperation, collaboration, partnership, and co-regulation are significant contributory factors to successful compliance strategies.
A nonlinear magnetic circuit model for periodic eddy current problems using T,ϕ-ϕ formulation
Authors: Plasser Rene , Koczka Gergely , Bíró Oszkár 
Published: March 2017

Purpose
A transformer model is used as a benchmark for testing various methods to solve 3D nonlinear periodic eddy current problems. This paper aims to set up a nonlinear magnetic circuit problem to assess the solving procedure of the nonlinear equation system for determining the influence of various special techniques on the convergence of nonlinear iterations and hence the computational time.

Design/methodology/approach
Using the T,ϕ-ϕ formulation and the harmonic balance fixed-point approach, two techniques are investigated: the so-called “separate method” and the “combined method” for solving the equation system. When using the finite element method (FEM), the elapsed time for solving a problem is dominated by the conjugate gradient (CG) iteration process. The motivation for treating the equations of the voltage excitations separately from the rest of the equation system is to achieve a better-conditioned matrix system to determine the field quantities and hence a faster convergence of the CG process.

Findings
In fact, both methods are suitable for nonlinear computation, and for comparing the final results, the methods are equally good. Applying the combined method, the number of iterations to be executed to achieve a meaningful result is considerably less than using the separated method.

Originality/value
To facilitate a quick analysis, a simplified magnetic circuit model of the 3D problem was generated to assess how the different ways of solutions will affect the full 3D solving process. This investigation of a simple magnetic circuit problem to evaluate the benefits of computational methods provides the basis for considering this formulation in a 3D-FEM code for further investigation.
Harmonic losses in high-speed PM synchronous machines
Authors: Kruchinina Irina Yu. , Khozikov Yuvenaliy , Liubimtsev Alexandr , Paltceva Valentina 
Published: March 2017

Purpose
The purpose of this paper is the development of a new numerical method for the calculation of the air-gap magnetic flux harmonics in synchronous machines with permanent magnet (PM) excitation. The harmonic analysis results are used as input data for the eddy-current loss calculation and for the rotor heating evaluation.

Design/methodology/approach
The method is based on the finite element analysis (FEA). The model takes into account toothed stator design, rotor asymmetrical magnetic reluctance and saturation. At first, a series of static DC magnetic (magnetostatic) simulations is run. Each problem corresponds to specific rotor position and the momentary stator winding currents. The Fourier analysis performed for each problem yields the harmonic spectrum variation in time. Then, a series of AC magnetic (time-harmonic) simulations is run. Each problem corresponds to a specific harmonic. The result is the eddy-current losses distribution. After total loss is calculated, the heat transfer analysis is conducted.

Findings
The analysis reveals that 90 per cent of losses are located in the sleeve that holds PMs together. Rotor eccentricity brings even harmonics of low magnitude that have little impact on heating.

Originality/value
In general, the study requires transient electromagnetic analysis with motion. The purposed method allows to simplify the problem. The method is based on static and quasi-static (time-harmonic) problems simulation. It is fast and highly automated. The method allows simultaneous taking into account of tooth-order harmonics, stator winding harmonics and eccentricity for heating calculation.
Enhanced phase-domain synchronous machine model including saturation
Authors: Schmuelling Christoph , Kulig Stefan 
Published: March 2017

Purpose
The phase-domain synchronous machine model has advantages compared to the d/q model, as no transformation of currents is necessary at each time step in a network analysis. The purpose of this paper is to enhance the phase-domain model to calculate the current distribution of the damper bars, including the saturation.

Design/methodology/approach
The new enhanced phase-domain model of the synchronous machine has been modelled using Matlab-Simulink. The parameters of the model have been calculated by using FEA software.

Findings
It is shown that the simulation results of the new model show very good accordance to the reference model during a three-phase short circuit.

Originality/value
The enhanced model includes the calculation of the currents in the damper bar and is able to include the harmonics of the inductances.