bluuebunny/crossref_metadata_2025_split huggingface dataset:
Attitudes and Performance of Cardiologists Toward Sexual Issues in Cardiovascular Patients
Authors: Salehian Razieh , Khodaeifar Fatemeh , Naserbakht Morteza , Meybodi Azadeh 
Published: December 2016

AbstractIntroductionThe aim of the present study was to evaluate the attitudes and performance of cardiologists regarding sexual issues in patients with cardiovascular diseases.MethodsA nationwide survey was conducted in a sample of cardiologists, representative of Iranian cardiologists, in 2015.Main Outcome MeasuresAppropriate questionnaires were developed and used to ask participants about their attitudes, performance, and barriers regarding discussing sexual issues with patients with cardiovascular disease.ResultsThe study population consisted of 202 cardiologists (138 men and 63 women) with a mean age of 44.25 years (SD = 8.45). Overall, 93.15% of cardiologists agreed with the importance of discussing sexual issues with their patients with cardiovascular diseases. Almost 76.7% of cardiologists agreed they had a responsibility to deal with patients' sexual problems, and 79.9% of them were aware of the association of cardiovascular disease with sexual problems of cardiac patients, but only 33% of them were confident in their knowledge and skills in this regard. Only 10.6% of cardiologists reported they frequently or always assessed sexual problems with their patients, but 51.50% of them stated they were responding to patients' questions about sexual problems. There was a significant association between performance and responsibility.ConclusionThe results of this study indicate a gap between cardiologist's attitudes and their actual performance and that their professional responsibility to address patients' sexual issues is a significant parameter for better performance.
Different operation regimes of cylindrical triode-type electron accelerator studied by PIC code simulations
Authors: Fetzer R. , An W. , Weisenburger A. , Mueller G. 
Published: December 2016

AbstractThe performance of the converging electron beam generated in cylindrical triodes is systematically studied by particle-in-cell code simulations. Depending on the cathode and grid potentials applied, different operation regimes are identified. For low voltages between cathode and grid, laminar flow and homogeneous beam energy density at the target (anode) is obtained. This applies both to the case of unipolar electron flow and to bipolar flow with counter-streaming ions. Hereby, the electron emission current is enhanced by about 50% for bipolar flow compared with unipolar flow. A further increase by about 20% is obtained when electron backscattering at the target is enhanced due to a change of target material from aluminum to tungsten. For cathode-grid voltages exceeding a critical value, laminar flow is replaced by non-laminar flow regimes. For unipolar electron beams, a virtual cathode forms between grid and target, which leads to an inhomogeneous power density at the target. For the specific geometry investigated and the cathode potential fixed at −120 kV, the cathode-grid voltage threshold for the formation of the virtual cathode is ~32 kV for Al targets and ~28 kV for W targets. For bipolar flow, the laminar flow regime already ends at cathode-grid voltages of ~23 kV (Al target) and ~20 kV (W target), respectively, and is replaced by magnetic insulation at the beam edge. For increasing cathode-grid voltage, the magnetically insulated region extends until beam pinching occurs.
Acquittals in International Criminal Justice: Pyrrhic Victories?
Authors: VAN WIJK JORIS , HOLÁ BARBORA 
Published: December 2016

AbstractDespite the great body of academic research on international criminal justice, little attention has been given to the situation of those who have been acquitted. This article aims to fill this gap by offering an empirical overview of what happens to persons acquitted by the ICTY, ICTR, and the ICC. Rather than providing an in-depth legal analysis, the article emphasizes the challenges acquitted persons encounter. It discusses in particular: (1) to what extent and why some acquitted individuals are barred from residing in the country of their preference; (2) whether and why they are facing subsequent prosecution; and (3) what obstacles there are for acquitted persons seeking to obtain compensation for the lengthy periods spent in detention. Although similar problems may be experienced by individuals who have been acquitted for conventional crimes in domestic systems, the authors argue that persons acquitted by international criminal tribunals are relatively more susceptible to post-acquittal challenges because of the unique nature of the alleged crimes and the institutional context in which international criminal trials take place. The authors conclude that there are no easy solutions, and that some of the problems identified are inherent to the system of international criminal justice.
Arginine–vasopressin therapy in hypotensive neonates and infants after cardiac surgery: response is unrelated to baseline ventricular function
Authors: Iliopoulos Ilias , Flores Saul , Pratap J. N. , Cooper David S. , Cassedy Amy , Nelson David P. 
Published: December 2016

AbstractWe hypothesised that infants with ventricular dysfunction after cardiac surgery have impaired haemodynamic response to arginine–vasopressin therapy. We retrospectively reviewed the medical records of neonates and infants treated with arginine–vasopressin within 48 hours of corrective or palliative cardiac surgery who underwent echocardiographic assessment of ventricular function before initiation of therapy. Patients were classified as “responders” if their systolic blood pressure increased by ⩾10% without increase in catecholamine score or if it was maintained with decreased catecholamine score. Response was assessed 1 hour after maximum upward titration of arginine–vasopressin. A total of 36 children (15 neonates) were reviewed (17 male). The median (interquartile) age was 10.4 weeks (1.1–26.9), and the median weight was 4.3 kg (3.2–5.8). Diagnoses included single ventricle (eight), arch abnormalities (five), atrioventricular septal defect (four), double-outlet right ventricle (three), tetralogy of Fallot (three), and others (13). In all, 12 patients (33%) had ventricular dysfunction. Only 15 (42%) responded favourably according to our definition 1 hour after the “target” arginine–vasopressin dose was achieved. Ventricular dysfunction was not associated with poor response. The overall mortality was 25%, but mortality in patients with ventricular dysfunction was 42%. Favourable response was associated with shorter ICU stay (9.5 days versus 19.5 days, p=0.01). We conclude that arginine–vasopressin fails to increase blood pressure in ~50% of hypotensive children after cardiac surgery. The response rate does not increase with duration of therapy. Ventricular function does not predict haemodynamic response. The mortality in this group is very high. Prospective comparison of vasopressin with other vasoactive agents and/or inotropes is warranted.
Paramedic Application of a Triage Sieve: A Paper-Based Exercise
Authors: Cuttance Glen , Dansie Kathryn , Rayner Tim 
Published: December 2016

AbstractIntroductionTriage is the systematic prioritization of casualties when there is an imbalance between the needs of these casualties and resource availability. The triage sieve is a recognized process for prioritizing casualties for treatment during mass-casualty incidents (MCIs). While the application of a triage sieve generally is well-accepted, the measurement of its accuracy has been somewhat limited. Obtaining reliable measures for triage sieve accuracy rates is viewed as a necessity for future development in this area.ObjectiveThe goal of this study was to investigate how theoretical knowledge acquisition and the practical application of an aide-memoir impacted triage sieve accuracy rates.MethodTwo hundred and ninety-two paramedics were allocated randomly to one of four separate sub-groups, a non-intervention control group, and three intervention groups, which involved them receiving either an educational review session and/or an aide-memoir. Participants were asked to triage sieve 20 casualties using a previously trialed questionnaire.ResultsThe study showed the non-intervention control group had a correct accuracy rate of 47%, a similar proportion of casualties found to be under-triaged (37%), but a significantly lower number of casualties were over-triaged (16%). The provision of either an educational review or aide-memoir significantly increased the correct triage sieve accuracy rate to 77% and 90%, respectively. Participants who received both the educational review and aide-memoir had an overall accuracy rate of 89%. Over-triaged rates were found not to differ significantly across any of the study groups.ConclusionThis study supports the use of an aide-memoir for maximizing MCI triage accuracy rates. A “just-in-time” educational refresher provided comparable benefits, however its practical application to the MCI setting has significant operational limitations. In addition, this study provides some guidance on triage sieve accuracy rate measures that can be applied to define acceptable performance of a triage sieve during a MCI.CuttanceG, DansieK, RaynerT. Paramedic application of a triage sieve: a paper-based exercise. Prehosp Disaster Med. 2017;32(1):3–13.
Emotional processing during psychotherapy among women newly diagnosed with a gynecological cancer
Authors: Manne Sharon L. , Myers-Virtue Shannon , Darabos Katie , Ozga Melissa , Heckman Carolyn , Kissane David , Rotter David 
Published: December 2016

AbstractObjective:Our aim was to compare changes in emotional processing by women newly diagnosed with gynecological cancer enrolled in either a coping and communication skills intervention (CCI) or a supportive counseling (SC) intervention. We examined the association between in-session emotional processing and patient-rated therapeutic progress.Method:Three therapy sessions with 201 patients were rated for the depth of emotional processing (peak and mode) during emotion episodes (EEs) using the Experiencing Rating Scale (EXP). Participants completed measures of dispositional emotional expressivity, depressive symptoms, and cancer-related distress before treatment began, as well as ratings of perceived progress in therapy after each session.Results:Peak EXP ratings averaged between 2.7 and 3.1, indicating that women discussed events, their emotional reactions, and their private experiences in sessions. A small proportion of patients had high levels of processing, indicating deeper exploration of the meaning of their feelings and experiences. Women in SC were able to achieve a higher level of emotional processing during the middle and later sessions, and during cancer-related EEs in the later session. However, emotional processing was not significantly associated with a patient's perceived therapeutic progress with SC. In the CCI group, higher levels of emotional processing were associated with greater session progress, suggesting that it may play an important role in patient-rated treatment outcomes.Significance of results:Newly diagnosed gynecological cancer patients are able to attend to their emotions and personal experiences, particularly when discussing cancer-related issues during both short-term SC and prescriptive coping skills interventions.
Hetero-type dual photoanodes for unbiased solar water splitting with extended light harvesting
Authors: Kim Jin Hyun , Jang Ji-Wook , Jo Yim Hyun , Abdi Fatwa F. , Lee Young Hye , van de Krol Roel , Lee Jae Sung 
Published: December 2016

AbstractMetal oxide semiconductors are promising photoelectrode materials for solar water splitting due to their robustness in aqueous solutions and low cost. Yet, their solar-to-hydrogen conversion efficiencies are still not high enough for practical applications. Here we present a strategy to enhance the efficiency of metal oxides, hetero-type dual photoelectrodes, in which two photoanodes of different bandgaps are connected in parallel for extended light harvesting. Thus, a photoelectrochemical device made of modified BiVO4 and α-Fe2O3 as dual photoanodes utilizes visible light up to 610 nm for water splitting, and shows stable photocurrents of 7.0±0.2 mA cm−2 at 1.23 VRHE under 1 sun irradiation. A tandem cell composed with the dual photoanodes–silicon solar cell demonstrates unbiased water splitting efficiency of 7.7%. These results and concept represent a significant step forward en route to the goal of >10% efficiency required for practical solar hydrogen production.
Functional screening for anti-CMV biologics identifies a broadly neutralizing epitope of an essential envelope protein
Authors: Gardner Thomas J. , Stein Kathryn R. , Duty J. Andrew , Schwarz Toni M. , Noriega Vanessa M. , Kraus Thomas , Moran Thomas M. , Tortorella Domenico 
Published: December 2016

AbstractThe prototypic β-herpesvirus human cytomegalovirus (CMV) establishes life-long persistence within its human host. The CMV envelope consists of various protein complexes that enable wide viral tropism. More specifically, the glycoprotein complex gH/gL/gO (gH-trimer) is required for infection of all cell types, while the gH/gL/UL128/130/131a (gH-pentamer) complex imparts specificity in infecting epithelial, endothelial and myeloid cells. Here we utilize state-of-the-art robotics and a high-throughput neutralization assay to screen and identify monoclonal antibodies (mAbs) targeting the gH glycoproteins that display broad-spectrum properties to inhibit virus infection and dissemination. Subsequent biochemical characterization reveals that the mAbs bind to gH-trimer and gH-pentamer complexes and identify the antibodies’ epitope as an ‘antigenic hot spot’ critical for virus entry. The mAbs inhibit CMV infection at a post-attachment step by interacting with a highly conserved central alpha helix-rich domain. The platform described here provides the framework for development of effective CMV biologics and vaccine design strategies.
Five colour variants of bright luminescent protein for real-time multicolour bioimaging
Authors: Suzuki Kazushi , Kimura Taichi , Shinoda Hajime , Bai Guirong , Daniels Matthew J. , Arai Yoshiyuki , Nakano Masahiro , Nagai Takeharu 
Published: December 2016

AbstractLuminescence imaging has gained attention as a promising bio-imaging modality in situations where fluorescence imaging cannot be applied. However, wider application to multicolour and dynamic imaging is limited by the lack of bright luminescent proteins with emissions across the visible spectrum. Here we report five new spectral variants of the bright luminescent protein, enhanced Nano-lantern (eNL), made by concatenation of the brightest luciferase, NanoLuc, with various colour hues of fluorescent proteins. eNLs allow five-colour live-cell imaging, as well as detection of single protein complexes and even single molecules. We also develop an eNL-based Ca2+ indicator with a 500% signal change, which can image spontaneous Ca2+ dynamics in cardiomyocyte and neural cell models. These eNL probes facilitate not only multicolour imaging in living cells but also sensitive imaging of a wide repertoire of proteins, even at very low expression levels.
Directional interlayer spin-valley transfer in two-dimensional heterostructures
Authors: Schaibley John R. , Rivera Pasqual , Yu Hongyi , Seyler Kyle L. , Yan Jiaqiang , Mandrus David G. , Taniguchi Takashi , Watanabe Kenji , Yao Wang , Xu Xiaodong 
Published: December 2016

AbstractVan der Waals heterostructures formed by two different monolayer semiconductors have emerged as a promising platform for new optoelectronic and spin/valleytronic applications. In addition to its atomically thin nature, a two-dimensional semiconductor heterostructure is distinct from its three-dimensional counterparts due to the unique coupled spin-valley physics of its constituent monolayers. Here, we report the direct observation that an optically generated spin-valley polarization in one monolayer can be transferred between layers of a two-dimensional MoSe2–WSe2 heterostructure. Using non-degenerate optical circular dichroism spectroscopy, we show that charge transfer between two monolayers conserves spin-valley polarization and is only weakly dependent on the twist angle between layers. Our work points to a new spin-valley pumping scheme in nanoscale devices, provides a fundamental understanding of spin-valley transfer across the two-dimensional interface, and shows the potential use of two-dimensional semiconductors as a spin-valley generator in two-dimensional spin/valleytronic devices for storing and processing information.
High-throughput computational design of cathode coatings for Li-ion batteries
Authors: Aykol Muratahan , Kim Soo , Hegde Vinay I. , Snydacker David , Lu Zhi , Hao Shiqiang , Kirklin Scott , Morgan Dane , Wolverton C. 
Published: December 2016

AbstractCathode degradation is a key factor that limits the lifetime of Li-ion batteries. To identify functional coatings that can suppress this degradation, we present a high-throughput density functional theory based framework which consists of reaction models that describe thermodynamic and electrochemical stabilities, and acid-scavenging capabilities of materials. Screening more than 130,000 oxygen-bearing materials, we suggest physical and hydrofluoric-acid barrier coatings such as WO3, LiAl5O8 and ZrP2O7 and hydrofluoric-acid scavengers such as Sc2O3, Li2CaGeO4, LiBO2, Li3NbO4, Mg3(BO3)2 and Li2MgSiO4. Using a design strategy to find the thermodynamically optimal coatings for a cathode, we further present optimal hydrofluoric-acid scavengers such as Li2SrSiO4, Li2CaSiO4 and CaIn2O4 for the layered LiCoO2, and Li2GeO3, Li4NiTeO6 and Li2MnO3 for the spinel LiMn2O4 cathodes. These coating materials have the potential to prolong the cycle-life of Li-ion batteries and surpass the performance of common coatings based on conventional materials such as Al2O3, ZnO, MgO or ZrO2.
Angular dependent anisotropic terahertz response of vertically aligned multi-walled carbon nanotube arrays with spatial dispersion
Authors: Zhou Yixuan , E. Yiwen , Xu Xinlong , Li Weilong , Wang Huan , Zhu Lipeng , Bai Jintao , Ren Zhaoyu , Wang Li 
Published: December 2016

AbstractSpatial dispersion effect of aligned carbon nanotubes (CNTs) in the terahertz (THz) region has significance for both theoretical and applied consideration due to the unique intrinsically anisotropic physical properties of CNTs. Herein, we report the angular dependent reflection of p-polarized THz wave from vertically aligned multi-walled CNT arrays in both experiment and theory. The spectra indicate that the reflection depends on the film thickness of vertically aligned CNTs, the incident angle, and the frequency. The calculation model is based on the spatial dispersion effect of aligned CNTs and performed with effective impedance method and the Maxwell-Garnett approximation. The results fit well with the experiment when the thickness of CNT film is thin, which reveals a coherent superposition mechanism of the CNT surface reflection and CNTs/Si interface reflection. For thick CNT films, the CNTs/Si interface response determines the reflection at small incident angles, while the CNTs surface effect dominates at large incident angles. This work investigates the spatial dispersion effect of vertically aligned CNT arrays in the THz region, and paves a way for potential anisotropic THz applications based on CNTs with oblique incidence requirements.
Noninvasive Electroencephalogram Based Control of a Robotic Arm for Reach and Grasp Tasks
Authors: Meng Jianjun , Zhang Shuying , Bekyo Angeliki , Olsoe Jaron , Baxter Bryan , He Bin 
Published: December 2016

AbstractBrain-computer interface (BCI) technologies aim to provide a bridge between the human brain and external devices. Prior research using non-invasive BCI to control virtual objects, such as computer cursors and virtual helicopters, and real-world objects, such as wheelchairs and quadcopters, has demonstrated the promise of BCI technologies. However, controlling a robotic arm to complete reach-and-grasp tasks efficiently using non-invasive BCI has yet to be shown. In this study, we found that a group of 13 human subjects could willingly modulate brain activity to control a robotic arm with high accuracy for performing tasks requiring multiple degrees of freedom by combination of two sequential low dimensional controls. Subjects were able to effectively control reaching of the robotic arm through modulation of their brain rhythms within the span of only a few training sessions and maintained the ability to control the robotic arm over multiple months. Our results demonstrate the viability of human operation of prosthetic limbs using non-invasive BCI technology.
Parallel Metabolomic Profiling of Cerebrospinal Fluid and Serum for Identifying Biomarkers of Injury Severity after Acute Human Spinal Cord Injury
Authors: Wu Yiman , Streijger Femke , Wang Yining , Lin Guohui , Christie Sean , Mac-Thiong Jean-Marc , Parent Stefan , Bailey Christopher S. , Paquette Scott , Boyd Michael C. , Ailon Tamir , Street John , Fisher Charles G. , Dvorak Marcel F. , Kwon Brian K. , Li Liang 
Published: December 2016

AbstractSuffering an acute spinal cord injury (SCI) can result in catastrophic physical and emotional loss. Efforts to translate novel therapies in acute clinical trials are impeded by the SCI community’s singular dependence upon functional outcome measures. Therefore, a compelling rationale exists to establish neurochemical biomarkers for the objective classification of injury severity. In this study, CSF and serum samples were obtained at 3 time points (~24, 48, and 72 hours post-injury) from 30 acute SCI patients (10 AIS A, 12 AIS B, and 8 AIS C). A differential chemical isotope labeling liquid chromatography mass spectrometry (CIL LC-MS) with a universal metabolome standard (UMS) was applied to the metabolomic profiling of these samples. This method provided enhanced detection of the amine- and phenol-containing submetabolome. Metabolic pathway analysis revealed dysregulations in arginine-proline metabolism following SCI. Six CSF metabolites were identified as potential biomarkers of baseline injury severity, and good classification performance (AUC > 0.869) was achieved by using combinations of these metabolites in pair-wise comparisons of AIS A, B and C patients. Using the UMS strategy, the current data set can be expanded to a larger cohort for biomarker validation, as well as discovering biomarkers for predicting neurologic outcome.