bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of nitrogen supply on leaf water relations and physiological traits in a set of potato (Solanum tuberosumL.) cultivars under drought stress
Authors: Meise P. , Seddig S. , Uptmoor R. , Ordon F. , Schum A. 
Published: January 2018

AbstractImproved adaptation of potato to limited water availability is needed for stable yields under drought. The maintenance of the cell water status and protection of cellular components against dehydration are important for drought tolerance, and the N status of plants affects the regulation of various respective metabolic processes. A 2‐year pot trial with 17 potato cultivars was conducted under a rain‐out shelter including two water regimes and two N‐levels to investigate genotypic differences concerning osmotic adjustment (OA) and relevant biochemical traits in relation to nitrogen (N) supply. Drought stress resulted in a rapid decrease in the leaf osmotic potential. The N, protein and proline contents increased under drought, while the N protein/NKjeldahlratio decreased. Initially, total soluble sugars increased at both N‐levels but dropped back to the control level at high N‐availability under prolonged drought while remaining high in N‐deficient plants. Results indicate that potatoes have only a limited capacity of activeOAand that increasing sugar and proline concentrations are rather associated with the protection of cellular components. High N supply promoted the N protein/NKjeldahlratio at short‐term drought and enhanced proline accumulation. Significant genotypic differences were observed for all investigated traits.
Mexiletine or catheter ablation after amiodarone failure in the VANISH trial
Authors: Deyell Marc W. , Steinberg Christian , Doucette Steve , Parkash Ratika , Nault Isabelle , Gray Chris , Essebag Vidal , Gardner Martin , Sterns Laurence D. , Healey Jeff S. , Hruczkowski Tomasz , Rivard Lena , Leong‐Sit Peter , Nery Pablo B. , Sapp John L. 
Published: January 2018

AbstractIntroductionIn patients with ischemic heart disease and ventricular tachycardia (VT) refractory to high dose amiodarone, the two most common therapeutic options are adjunctive mexiletine therapy or catheter ablation. There are little existing data on the efficacy of these strategies. We examined the relative efficacy of adjunctive mexiletine and catheter ablation among patients enrolled in the VANISH trial.MethodsAll subjects enrolled in the VANISH trial who had VT refractory to high dose (≥ 300 mg daily) amiodarone at baseline were included. Per protocol, subjects randomized to escalated drug therapy received adjunctive mexiletine.ResultsNineteen of the 259 patients were receiving high‐dose amiodarone at baseline and 11 were randomized to escalated therapy with mexiletine and 8 to ablation. The adjunctive mexiletine group had a higher rate of the primary composite outcome (death, VT storm, or appropriate shock) in comparison to catheter ablation (HR 6.87 [2.08–22.8]). Over 90% of the patients in the adjunctive mexiletine/group experienced a primary endpoint during a median 9.2 months’ follow‐up. There was no difference in the rate of adverse events between the two groups.ConclusionsMexiletine has limited efficacy in the treatment of recurrent VT despite high‐dose amiodarone therapy, in patients with ischemic heart disease. Catheter ablation is a superior strategy in this population.
Development of an online, universal, Utstein registry‐based, care practice report card to improve out‐of‐hospital resuscitation practices
Authors: Baert Valentine , Escutnaire Joséphine , Nehme Ziad , Mols Pierre , Lagadec Steven , Vilhelm Christian , Jacob Line , Wiel Eric , Adnet Frédéric , Hubert Hervé ,   on behalf GR‐RéAC
Published: January 2018

AbstractRationale, aims and objectivesCare quality is a primary concern in health field. In France, the care practice report card (CPRC) is compulsory for practitioners. It is the first step towards the culture of excellence. In this context, practitioners have to assess and improve their practices. Competent authorities define registries as reliable sources for CPRC. The first aim of this work is to describe how we designed and built a universally transposable CPRC model based on an Utstein‐style cardiac arrest registry. The second aim is to measure the adherence of practitioners to this approach and to show how such a tool can be used in real situation.MethodsOur report card is adapted from in‐hospital CA care quality and safety indicators. We built a 2‐section grid. The first part described the quality and completeness of the analysed data. The second part distinguished medical and traumatic CA and assesses care practices. We analysed the practitioners' adherence thanks to a satisfaction survey. Finally, we presented a CPRC case study.ResultsThis tool was tested in 92 centres gathering 8433 patients. The satisfaction survey showed that this CPRC was well accepted by emergency professionals. We presented an implementation example of this tool in a centre in real‐life situation.ConclusionsWe designed and implemented a fully automated CPRC tool routinely usable for Utstein‐style CA registries. This CPRC is easily transferable in all other Utstein CA registries. The debriefing report source codes are freely distributed upon request. This tool enables the care assessment and improvement.
Where Are Antipsychotics Prescribed in Nursing Homes Initiated?
Authors: Zhang Yan , Letuchy Elena M. , Carnahan Ryan M. 
Published: January 2018

OBJECTIVESTo describe the settings of care in which antipsychotics that nursing home (NH) residents received were likely to have been initiated.DESIGNCross‐sectional.SETTINGIowa NHs.PARTICIPANTSFee‐for‐service Medicare beneficiaries who had NH stays between January 1, 2011, and December 31, 2014, and had new use of antipsychotics during their NH stays, defined as no antipsychotic use in NHs in the last 6 months.MEASUREMENTSA linked dataset of Chronic Condition Data Warehouse Medicare claims and Long‐Term Care Minimum Data Set (MDS) 3.0 was used to determine care settings of antipsychotic initiations.RESULTSOf 7,496 residents with new antipsychotic use in NHs, 4,794 (64.0%, 95% confidence interval (CI) = 62.9–65.0%) initiated them in NHs, 1,392 (18.6%, 95% CI 17.7–19.5%) appeared to have had them initiated in hospitals, and 1,310 (17.5%, 95% CI = 16.6–18.3%) had antipsychotics first dispensed as outpatients. Antipsychotics were commonly prescribed during the early NH stays, and 3,026 (40.4%, 95% CI = 39.3–41.5%) of the entire sample received antipsychotic therapy within the first 7 days after NH admissions. Fifty‐eight percent (n = 4,348) of the study residents initiating antipsychotics had potentially appropriate antipsychotic indications according toMDS records.CONCLUSIONMost residents initiated antipsychotic therapy in NHs, confirming that NH providers are appropriate primary target of interventions to reduce antipsychotic initiation in their residents. However, many antipsychotics were continued from other settings, indicating a need to evaluate the necessity of continued antipsychotic treatment after such transitions of care. J Am Geriatr Soc 66:1082–1088: 2018.
Environmental Implications of Future Demand Scenarios for Metals: Methodology and Application to the Case of Seven Major Metals
Authors: Van der Voet Ester , Van Oers Lauran , Verboon Miranda , Kuipers Koen 
Published: January 2018

SummaryIn this paper, we develop a method to assess the environmental impacts of metal scenarios. The method is life cycle based, but enables forward looking and upscaling. The method aims at translating metal demand scenarios into technology‐specific supply scenarios, necessary to make the translation into environmental impacts. To illustrate the different steps of the methodology, we apply it to the case of seven major metals. Demand scenarios for seven major metals are taken from literature. We translate those into technology‐specific supply scenarios, and future time series of environmental impacts are specified including recycling rates, energy system transformation, efficiency improvement, and ore grade decline. We show that the method is applicable and may lead to relevant and, despite many uncertainties, fairly robust results. The projections show that the environmental impacts related to metal production are expected to increase steeply. Iron is responsible for the majority of impacts and emissions are relatively unaffected by changes in the production and energy system. For the other metals, the energy transition may have substantial benefits. By far, the most effective option for all metals appears to be to increase the share of secondary production. This would reduce emissions, but is expected to become effective only in the second half of the twenty‐first century. The circular economy agenda for metals is therefore a long‐term agenda, similar to climate change: Action must be taken soon while benefits will become apparent only at the long term.
Raise Rates to Raise Inflation? Neo‐Fisherianism in the New Keynesian Model
Authors: GARÍN JULIO , LESTER ROBERT , SIMS ERIC 
Published: January 2018

AbstractIncreasing the inflation target in a New Keynesian (NK) model may require increasing, rather than decreasing, the nominal interest rate in the short run. We refer to this positive short‐run comovement between the nominal rates and inflation conditional on a nominal shock as Neo‐Fisherianism. We show that the NK model is more likely to be Neo‐Fisherian the more persistent is the change in the inflation target and the more flexible are prices. Neo‐Fisherianism is driven by the forward‐looking nature of the model. Modifications that make the framework less forward‐looking make it less likely for the model to exhibit Neo‐Fisherianism.
Maternal and child health nurses work with refugee families: Perspectives from regional Victoria, Australia
Authors: Willey Suzanne M , Cant Robyn P , Williams Allison , McIntyre Meredith 
Published: January 2018

Aims and objectivesTo explore service provision for Victorian regional refugee families from the perspective of maternal and child health nurses.BackgroundIncreasingly, more families from a refugee background are resettling in regional Victoria. The refugee journey has significant effect on families. Refugee families with infants and young children can be provided with support by maternal and child health services; however, many families experience barriers to ongoing engagement with this service.DesignThis descriptive study used focus group and questionnaire. A purposive sample of 26 maternal and child health nurses was drawn from six municipalities throughout regional Victoria, where higher numbers of people from a refugee background resettle. Six focus groups were held in 2014. Audio‐recorded narratives were transcribed, prior to inductive thematic analysis.MethodsThis descriptive study used focus group and questionnaire. A purposive sample of 26 Maternal and Child Health nurses was drawn from six municipalities throughout regional Victoria where higher numbers of people from a refugee background resettle. Six focus groups were held in 2014. Audio‐recorded narratives were transcribed verbatim, prior to inductive thematic analysis.ResultsParticipating nurses were experienced nurses, averaging 12 years in the service. Four major themes emerged from thematic analysis: “How to identify women from a refugee background”; “The Maternal and Child Health nurse role when working with families from a refugee background”; “Interpreting issues”; and “Access to other referral agencies.” Nurses worked to develop a relationship with families, attending to a complex mix of issues which were complicated by language barriers. Nurses found their role in supporting refugee families required additional time and more home visits.ConclusionsTo provide best practice, maternal and child health nurses need (i) ongoing professional development; (ii) time, flexibility and creativity to build relationships with refugee families and (iii) better access to services that enhance communication, such as interpreting services and translated resources.Relevance to clinical practiceNurses require ongoing professional development to help them address the multifaceted needs of families of refugee background. With limited resources available in regional areas, accessing further education can be challenging. Distance education models and organisational support could provide nurses with educational opportunities aimed at improving service provision and clinical practice.
The Pēpi‐Pod study: Overnight video, oximetry and thermal environment while using an in‐bed sleep device for sudden unexpected death in infancy prevention
Authors: Tipene‐Leach David , Baddock Sally A , Williams Sheila M , Tangiora Angeline , Jones Raymond , McElnay Caroline , Taylor Barry J 
Published: January 2018

AimThe aim of this study was to identify the potential risks and benefits of sleeping infants in a Pēpi‐Pod distributed to families with high risk of sudden unexpected death in infancy compared to a bassinet.MethodsForty‐five mostly indigenous Māori mothers who were referred by local health providers to receive a Pēpi‐Pod were surveyed at recruitment, 1 and 3 months. A sleep study at 1 month included infrared video, oximetry and temperature measures.ResultsWhen compared with 89 historical bassinet controls, an intention‐to‐treat analysis of questionnaires showed no increase in direct bed sharing but demonstrated significantly less sharing of the maternal bedroom at both interviews, with the majority of those not sleeping in the maternal bedroom, actually sleeping in the living room. The 1 month ‘as‐used’ analysis showed poorer maternal sleep quality. The ‘as‐used’ analysis of video data (24 Pēpi‐Pod and 113 bassinet infants) also showed no increase in direct bed sharing, head covering or prone/side sleep position. Differences in oxygen saturation were not significant, but heart rate was higher in the Pēpi‐Pod infants by 8.37 bpm (95% confidence interval 4.40, 12.14). Time in the thermal comfort zone was not different between groups despite Pēpi‐Pod infants being situated in significantly warmer rooms.ConclusionsOverall, we found that most differences in infant risk behaviours in a Pēpi‐Pod compared to a bassinet were small, with confidence intervals excluding meaningful differences. We noted poorer maternal sleep quality at 1 month. Higher infant heart rates in the Pēpi‐Pod group may be related to higher room temperatures. The Pēpi‐Pod appears physiologically safe but is associated with lower reported maternal sleep quality.
Occurrence and correlations of nematodes, Fusarium oxysporum and edaphic factors on banana plantations
Authors: Almeida Nayane Oliveira , Teixeira Renato Andrade , Carneiro Franciele Alves , de Oliveira Camilla Martins , Ribeiro Victor Alves , Lobo Júnior Murillo , Rocha Mara Rúbia da 
Published: January 2018

AbstractProblems caused by nematodes and Fusarium wilt (Panama disease) on banana plantations are responsible for yield losses and are limiting to its cultivation. In the state of Goias, there is little information about the nematode occurence on this crop, and its relation with the incidence of Fusarium oxysporum f.sp. cubense (Foc). This research had the purpose to identify the occurrence of plant‐parasitic nematodes on banana plantations and to verify its correlation with the Fusarium wilt and with the soil attributes (pH, texture, nutrients). Twelve banana orchards in the state of Goias were sampled in the municipalities of Anapolis, Caiaponia, Goiatuba, Itaguaru, Itumbiara (two areas), Jatai, Morrinhos, Ouro Verde, Palestina, Taquaral and Uruana. All sampled areas, except Morrinhos, revealed contamination with Foc, and all areas had different genera of nematodes either in the soil or in the roots samples. Meloidogyne sp., Helicotylenchus sp. and Rotylenchus sp. were the main genera of plant‐parasitic nematodes found in the samples, with Meloidogyne sp. and Rotylenchus sp. being the most dominant and abundant genera. The presence of Pratylenchus sp. increases the population levels of F. oxysporum. Helicotylenchus sp. is highly correlated with high concentrations of Mn. High population density of Meloidogyne sp. was found in irrigated areas with low concentrations of P, Ca, Mg and soil pH.
Prevalence and disease associations in feline thrombocytopenia: a retrospective study of 194 cases
Authors: Ellis J. , Bell R. , Barnes D.C. , Miller R. 
Published: January 2018

ObjectivesTo assess the prevalence of thrombocytopenia in a referral population of cats in the UK, to identify disease processes associated with thrombocytopenia and to assess the proportion of thrombocytopenic cats that tested positive for feline leukaemia virus or feline immunodeficiency virus.Materials and MethodsRetrospective analysis of medical records at a UK referral hospital. Cats were grouped by mechanism of thrombocytopenia and disease process (where known).ResultsPrevalence of thrombocytopenia was 5·9%. The most common disease processes associated with thrombocytopenia were haematological or infectious disease and neoplasia; 11% of thrombocytopenic cats tested were positive for feline leukaemia virus, which is lower than reported previously. Cats presenting with unexplained haemorrhage had significantly lower platelet counts than other thrombocytopenic cats. Primary immune‐mediated thrombocytopenia was less commonly diagnosed than in dogs and associated with the most severe platelet depletion in this study.Clinical SignificanceThrombocytopenia in cats may be more prevalent than previously reported and severe thrombocytopenia may be associated with spontaneous haemorrhage. Severe thrombocytopenia in cats appears less commonly immune‐mediated than in dogs. Thrombocytopenia did not appear to be associated with retroviral infections.
PCR evaluation of selected vector‐borne pathogens in dogs with pericardial effusion
Authors: Tabar M.‐D. , Movilla R. , Serrano L. , Altet L. , Francino O. , Roura X. 
Published: January 2018

ObjectivesTo investigate evidence for selected vector‐borne pathogen infections in dogs with pericardial effusion living in a Mediterranean area in which several canine vector‐borne diseases are endemic.Materials and MethodsArchived EDTA blood (n=68) and pericardial fluid samples (n=58) from dogs with pericardial effusion (n=68) were included. Dogs without pericardial effusion examined for other reasons were included as controls (n=60). Pericardial effusion was classified as neoplastic in 40 dogs, idiopathic in 23 dogs and of unknown aetiology in 5 dogs. Real‐time PCR was performed for Leishmania infantum, Ehrlichia/Anaplasma species, Hepatozoon canis, Babesia species, Rickettsia species and Bartonella species, and sequencing of PCR products from positive samples was used to confirm species specificity.ResultsVector‐borne pathogens were found in 18 dogs: 16 of 68 dogs with pericardial effusion (23·5%) and two of 60 control dogs (3·3%). Positive dogs demonstrated DNA of Leishmania infantum (n=7), Anaplasma platys (n=2, one dog coinfected with Leishmania infantum), Babesia canis (n=5), Babesia gibsoni (n=3) and Hepatozoon canis (n=2). Vector‐borne pathogens were more commonly detected among dogs with pericardial effusion than controls (P=0·001). There was no relationship between aetiology of the pericardial effusion and evidence of vector‐borne pathogens (P=0·932).Clinical SignificanceVector‐borne pathogens are often detected in dogs with pericardial effusion and require further investigation, especially in dogs with idiopathic pericardial effusion. PCR can provide additional information about the potential role of vector‐borne pathogens in dogs with pericardial effusion living in endemic areas.
Tracking the Real‐Time Evolution of a Writing Event: Second Language Writers at Different Proficiency Levels
Authors: Gánem‐Gutiérrez Gabriela Adela , Gilmore Alexander 
Published: January 2018

AbstractThe current study focused on emergent processes during real‐time second language (L2) writing activity in an English as a foreign language university context, examining differences in these processes across individual capacities. Participants included 22 adult Japanese learners of L2 English and their tutor. The data were collected using digital screen capture and eye‐tracking technologies while the learners wrote a 35‐minute argumentative essay. Supplementary stimulated retrospective recalls were also conducted to document the learners’ and the tutor's reflections on the writing event. Results revealed clear differences in L2 writing activity at different periods in time as well as differences in cognitive activity that appear to be mediated by L2 proficiency. Importantly, the obtained patterns differed depending on whether duration or frequency data were considered. These findings thus demonstrate the need to broaden the study of the temporal dimension of L2 writing and to consider more nuanced mixed‐methods approaches in future work.
High number of PD‐1 positive intratumoural lymphocytes predicts survival benefit of cytokine‐induced killer cells for hepatocellular carcinoma patients
Authors: Chang Boyang , Shen Lujun , Wang Kefeng , Jin Jietian , Huang Tao , Chen Qifeng , Li Wang , Wu Peihong 
Published: January 2018

AbstractBackground & AimsAdjuvant cytokine‐induced killer (CIK) cells treatment has shown potential in reducing the recurrence rate and prolonging the survival of patients with hepatocellular carcinoma (HCC). We aimed to identify the best predictive biomarker for adjuvant CIK cells treatment in patients with HCC after curative resection.MethodsThis study retrospectively included 145 pairs of HCC patients by one‐to‐one propensity score matching. One group received CIK cells transfusion after surgery (surgery‐CIK group); the other one group underwent surgery only (surgery‐only group). Immunohistochemistry (IHC) was used to measure PD‐1, PD‐L1, CD4, CD8 and Foxp3 expression in tumour tissues of surgery‐CIK group; IHC of PD‐1 and PD‐L1 was conducted in the surgery‐only group.ResultsThe surgery‐CIK group had a significantly higher disease‐free survival (DFS) and overall survival (OS) rates compared to the surgery‐only group. Of all the intratumoural biomarkers, in the surgery‐CIK group, multivariate analysis showed that a high number of PD‐1+ tumour infiltrative lymphocytes (TILs) was the only factor that independently predicted favourable OS and DFS. By contrast, in the surgery‐only group, no significant correlations between PD‐1/PD‐L1 expression and survival of patients were identified. Further correlation analysis showed a high number of PD‐1+ TILs associated with a high number of both CD4+ and CD8+ TILs in surgery‐CIK group.ConclusionsA high number of PD‐1+ TILs can serve as a potent biomarker for adopting CIK cells therapy in HCC patients after curative resection.
Purpose‐built national burns center: The Israeli experience
Authors: Ofir Hagit , Shefler Hadas , Kornhaber Rachel , Cleary Michelle , Harats Moti , Haik Josef 
Published: January 2018

AbstractThe opening of the National Burns Center (NBC) in Sheba Medical Center (SMC) in 2014 was a keystone point in the development of specialized burns trauma services for Israel to ensure burn care and disaster planning at international standards. The NBC is a purpose‐built, level 1 burns trauma center that receives patients from Israel, Gaza, West Bank, and abroad. Hosting six intensive care and four step‐down burns beds, the center serves as a referral center for patients in other health‐care facilities with indication for hospitalization. In the present study, we describe the planning, design, and organization of the NBC at the SMC with reference to some of the key areas and considerations in its conception and development. With the improved survival rates of patients with extensive burns and the demographics and characteristics among burn‐injury patients in Israel, the NBC has the capacity to be the center of excellence in burns care, teaching, and research within the Middle East.