bluuebunny/crossref_metadata_2025_split huggingface dataset:
Process Evaluation of the Follow-Up Care System for Suicide Attempt in Iran: A Mixed- Method Study
Authors: Shirzad Fatemeh , Fahim Forouzan , Naserbakht Morteza , Hajebi Ahmad , Shariat Seyed Vahid , Naseh Mohammad Hadi , Ahadi Parisa , Khougar Ansar 
Published: October 2024

Abstract

Background
Despite ongoing efforts to provide hospital and post-discharge care for suicide attempters in Iran, national suicide rates continue to exhibit a concerning upward trend. This study employs the MRC framework, a comprehensive evaluation tool, to conduct a process evaluation of Iran's suicide follow-up care system in Shahriar city.
Methods
We examined fidelity, dosage, reach, impact, and contextual determinants of the program. An explanatory sequential design was employed. Data from 992 suicide attempt cases collected between April and September 2023. Semi-structured interviews were conducted with 19 mental health workers, 2 mental health experts, 16 hospital staff members, and 8 individuals with who have suicide attempts.
Results
Findings indicated that of the 992 individuals referred for receive services, only a small number (n = 15) engaged with designated health centers, with a completion rate of a mere 3 individuals, suggesting significant limitations in program reach. Qualitative analysis revealed nine thematic domains aligned with the MRC framework: infrastructure, information gaps, and human resource challenges within implementation mechanisms; participant experiences, and acceptability, related to impact mechanisms; and socioeconomic factors, stigma, organizational barriers, and access to means restriction as contextual components.
Conclusion
This study in Iran offers a unique contribution by employing a comprehensive framework to systematically evaluate the national suicide follow-up system, its role within broader prevention efforts, and strategies to enhance program effectiveness. The Follow-Up Care System for Suicide Attempt provides a crucial resource for Shahriar residents at risk of suicide, who often grapple with compounded challenges stemming from socioeconomic factors. Our findings underscore critical operational and contextual barriers, providing essential evidence for policymakers to address. While demonstrating initial promise, the program requires substantial improvements. To maximize its impact, we need to strengthen program implementation, allocate sufficient resources, build community partnerships, and advocate for policy changes that address the root causes of these issues.
Radiomic signature: A novel magnetic resonance imaging-based prognostic biomarker in patients with brainstem cavernous malformation
Authors: Huo Xulei , Yao Bo-Han , Guo Jia , Wang Hongwei , Wang Ke , Wang Liang , Wu Zhen , Li Da 
Published: October 2024

Abstract

OBJECTIVE: Based on anatomical magnetic resonance imaging (MRI) sequences, we developed a radiomic signature for brainstem cavernous malformation patients (BSCMs) using radiomic analysis and explore its effectiveness as a prognostic biomarker.
METHODS:One hundred and fourteen BSCMs with clinical, and radiomic information were collected and randomly divided into training (n = 68) and validation set (n = 46). Clinical and radiomic nomogram were constructed for the prognosis. Radiomic features were screened with three algorithms (univariate analysis, Pearson analysis, and elastic net algorithm). Cox regression model was used to build the radiomics nomogram. Finally, concordance index (C-index), time-independent receiver operating characteristic (ROC) analysis, and Decision curve analysis (DCA) were utilized to evaluate the clinical application of the radiomics nomogram.
RESULTS: The radiomic signature score was calculated with 11 hemorrhage-free survival (HFS) related radiomic features from the training cohort. The patients were divided into high-risk group and low-risk group with the help of radiomic signature and the low-risk group has a better HFS than the high-risk group. In addition, three clinical characteristics including the number of hemorrhages, size, mRS, and radiomics score (Rad-score) were used to develop the radiomics nomogram. The calibration plots showed that the nomogram has good agreement between the predicted and actual survival probabilities. And, the C-index was 0.784 and 0.787 in the training cohort and validation cohort in predicting HFS; the area under curve (AUC) was 72.51 and 76.41 in the training cohort and validation cohort in 3-year survival and 67.62 and 72.57 in 5-year survival. Lastly, the DCA curve showed that the radiomics nomogram has a better clinical application than the clinical model.
CONCLUSIONS: Radiomics nomogram integrating radiomics signature and clinical information showed great performance and high sensitiveness in prediction HFS in BSCMs than the clinical model.
Study of Blood Eosinophils and Plasma Periostin as Biomarkers for Response of COPD Patients to ICS/LABA Treatment
Authors: Abdulsattar Sara Abdulbadie , Hantera Mohamed Sayed , Hodeb Hossam Abdel Mohsen , kholy Amira Abdelgalil El , Kholy Gamal Amer El 
Published: October 2024

Abstract

Background: Eosinophilic airway inflammation has been detected in up to 40% of chronic obstructive pulmonary disease (COPD) patients during stable periods of the disease and increased sputum eosinophil count was associated with better lung function, more future exacerbations, and symptoms that responded better to treatment with inhaled and oral corticosteroids.
The aim of this work was to investigate the relationship of blood eosinophils and plasma Periostin with lung function changes related to ICS and long-acting beta2- agonist combination treatment in stable COPD patients for three months.
Methods: This prospective experimental study was carried out on 50 COPD patients with post bronchodilator FEV1/ FVC ratio <70%. Patient collected from outpatient clinics of Chest Department Tanta University Hospitals, Tanta Chest Hospital and Mansoura Chest Hospital from February 2020 to February 2022.Patients subjected to complete history taking, clinical examinations including general and local examinations and laboratory investigations [complete blood count to assess eosinophilic count, arterial blood gases and plasma periostin] and spirometry were done for all patients pre and post treatment. All patients received three months of treatment with a fixed dose of combined inhalers of ICS and LABA and then they were classified into FEV1 responder and FEV1 non-responder according to improvement in FEV1 at least 12% and 200ml from base line of three months of combined treatment with ICS/LABA.
Results: Blood eosinophil count had a significant positive correlation with smoking index (pack/year), negative correlations with FEV1% of predicted, FEV1 actual value (L), FEV1/FVC ratio. Plasma periostin concentration had significant positive correlation with blood eosinophil count, COPD grade, FVC actual value (L) and significant negative correlations with FEV1% of predicted, FEV1 actual value (L) and FEV1/FVC. Cut off values of blood eosinophil count >265cell/ µL, plasma Periostin concentration >15.747 ng/ml and FEV1% < 40.5% were associated with post treatment FEV1 response.
Conclusions: COPD patients with poor lung functions regarding FEV1/FVC ratio, FEV1 actual value (L) and FEV1% of predicted as well as high blood eosinophil count and high plasma periostin concentration are predicted to have FEV1 response with fixed dose ICS/LABA combination treatment.
Virtual Post Mortem in fetuses and newborns for the Verification of Congenital Heart Malformations
Authors: Salem Yishay , Keizman Eitan , Jacobson Jeffrey , Goiten Orly , Katorza Eldad , Kassif Eran , Mishali David , Kidron Debora , Serraf Alain E , Konen Eli , Ahiron Reuven , Gindes Liat , Tejman-Yardem Shai , Tejman-Yarden Shai 
Published: October 2024

Abstract

Background and Objectives:
Post-mortem examinations of fetuses and newborns with congenital anomalies pose significant challenges, especially in cases of induced termination of pregnancy. To address this, we explored the use of virtual post-mortem examination (VPM) via computed tomography angiography (CTA) as a potential alternative.
Methods
The study was conducted at Sheba Medical Center from January 2013 to June 2019. It focused on 20 cases involving severe congenital heart defects or lung malformations affecting the heart. VPM imaging was performed using CTA with contrast medium injected into the umbilical artery and vein.
Results
Prenatal sonographic diagnoses were fully concordant with VPM findings, confirmed by authorized invasive autopsies in 7 cases. The standardized injection protocol enabled accurate imaging of the systemic and pulmonary vessels, aiding in the identification of vascular anomalies and the cardiac structures. However, visualization of intra-cardiac anatomy was limited, possibly due to valve competence and post mortem intra-ventricular Thrombi.
Conclusions
Compared to MRI, CT scans this method offers higher spatial resolution at a lower cost, making it a feasible complement to standard medical practice. Despite limitations in visualizing cardiac chambers, VPM with umbilical vessel injection proved highly accurate, particularly in assessing the great vessels. Overall, the findings suggest that VPM may offer a less invasive and acceptable alternative for grieving parents, providing valuable insights into complex congenital cardiac anomalies while respecting the sensitivity of post-mortem examinations in such cases.
RETRACTED: In silico investigation of the anti-leishmanial role of algae and corals active substances using molecular dynamic simulation and Molecular docking methods
Authors: Shabandoust Hajar , Balmeh Negar , Fard Najaf Allahyari , Saberi Sedighe , Yegdaneh Afsaneh , Mousavi Seyed Mahmoud , Alimardan Zahra , Najafabadi Zahra Ghayour , Hejazi Seyed Hossein 
Published: October 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
The Career Development of Food Delivery Riders in China: A Qualitative Investigation
Authors: Wan Wei , Liu Weihua , Hu Huiling 
Published: October 2024

Abstract

Background: With the rise of the gig economy, platform work has has grown significantly throughout the world. As one of the most dynamic platform workers in China, food delivery riders are an underrepresented group in terms of securing decent work. Building on the Psychology of Working Theory(PWT), the current study aimed to explore how contextual and individual factorsinfluenced the career development of food delivery riders in China. This study also examined their attitudes towards platform work and their career aspirations.
Methods: We conducted semi-structured interviews with 12 participants aged 18-45 and utilized Consensual Qualitative Research (CQR) approach to conduct data analysis.
Results: The results revealed that economic constraints, inadequate education, and limited social capital were the main vocational barriers for these riders. Their coping resources included social support, critical consciousness, proactive personality, and self-leadership. Although food delivery work allowed them to earn a living, it featured long working hours, poor working conditions, limited benefits, etc. As such, they experienced job dissatisfaction, occupational fatigue, and turnover intentions. Regarding future goals, our participants mentioned finding a more decent job, learning new skills, and starting a business.
Conclusion: Overall, this study marks the first known application of PWT to understand how food delivery riders navigate the new world of work in China. Practical implications and directions for future studies are discussed.
A Microbe-Drug Association Prediction Model Based on Graph Attention Network and Rotating Forest
Authors: Li Jing , Li Juncai , Chen Qijia , Wang Zhong , Liu Xianzhi , Liang Mingmin , Wang Junzhuang , Ding Hongyuan , Zeng Bin , Wang Lei 
Published: October 2024

Abstract

Background
In recent years, drug abuse has led to the increase of microbial resistance, therefore exploring possible connections between drugs and microorganisms becomes more and more important. However, since traditional biological experiments are very expensive and time-consuming, then creating effective computational models to predict possible associations between microbes and drugs turns to be a crucial and challenging work.
Result
In this paper, we proposed a new calculative model GATROF based on graph attention networks and rotating forests to infer potential microbe-drug correlations. In GATROF, we first constructed a heterogeneous microbe-drug network by combining multiple microbe, drug and disease similarity measures. And then, based on different characteristics of microbes and drugs, we further built two original feature matrices of microbe and drug. Subsequently, we inputted the heterogeneous microbe-drug network together with these two original feature matrices into the graph attention network to extract low dimensional feature representations for microbes and drugs separately. Finally, we further inputted these two low dimensional feature representations together with these two original feature matrices of microbes and drugs into a rotating forest classifier to infer latent associations between drugs and microorganisms.
Conclusion
Experimental results and case studies indicated that GATROF can achieve better performance in microbe-drug association prediction than existing advanced methods, which means that GATROF may make a satisfactory contribution to the field of medicine in the future.
Active Beta-Catenin (ABC) promotes an invasive phenotype in pediatric osteosarcoma
Authors: Persad Sujata , Hinton Kristin , Ghafoor Saima , Landry Takaaki , Garcia Elizabeth , Cohen Danielle , Bush Jonathan , Deyell Rebecca , Jay Daniel , Hitt Mary , Paul Paulose , Eisenstat David 
Published: October 2024

Abstract

Osteosarcoma (OS) is an aggressive primary bone malignancy with peak incidence in children and adolescents. Despite current multimodal treatments, there has been little change in overall survival outcomes in the last two decades.
The canonical Wnt/β-catenin pathway is known to be a critical pathway in OS progression. To better understand the molecular basis of OS and potentially provide target/s for new therapies or diagnostics, we investigated the relationship between β-catenin, more specifically, the transcriptionally active form of β-catenin, Activated β-Catenin (ABC), and OS progression. We previously reported an association between ABC and aggressive OS whereby, cellular/nuclear ABC levels, but not cellular/nuclear β-catenin levels, increase with the degree of aggressiveness. However, a direct role for ABC in promoting OS progression has not been shown.
In order to directly determine the role/impact of ABC in OS progression, we generated a pEGFP-ABC fusion construct which simulates ABC's phosphorylation pattern. Transfection of pEGFP-ABC, pEGFP-β-catenin, or an empty vector (pEGFP) into OS cell lines showed that wnt pathway transcriptional activity in GFP-ABC-expressing cells was significantly higher than that in both GFP-β-catenin and empty-vector-transfected cells. We also show that the in vitro invasive potential of the pEGFP-ABC-transfected cells was significantly higher compared to both pEGFP-β-catenin and pEGFP-transfected cells. Immunohistochemistry of clinical pediatric OS specimens supported these findings, showing a significant correlation between high ABC levels and invasive disease.
To the best of our knowledge, this is the first report that suggest that ABC drive transcriptional activity to enhance invasiveness in OS and could serve as a biomarker of aggressive or metastatic OS.
Ferguson plot analysis of chaperone ClpB from moderate halophile
Authors: Akuta Teruo , Tomioka Yui , Ura Tomoto , Nakagawa Masataka , Arakawa Tsutomu 
Published: October 2024

Abstract

Ferguson plot is a simple method to determine the molecular weight of native proteins and their complexes. We here tested the validity of Ferguson plot based on agarose native gel electrophoresis using multimeric chaperone protein, ClpB, derived from moderate halophile that forms a native hexamer. Ferguson plot showed a single band with a molecular weight of 1,500 kDa, about twice the size of the native hexamer, which may be consistent with the structure of other chaperons that form a double ring comprising a dimer of two hexamer assembly units, i.e, dodecamer. In fact, dynamic light scattering experiment showed two peaks, which appears to correspond to the hexamer and dodecamer structures.
Knowledge, Practice and Associated Factors to Ward Hypoglycemia Prevention Among Caregivers of Diabetic Children: Cross Sectional Study Design
Authors: Lidete Adisalem , Atsede ‬Gebrekidan , Mebrahtu Kaleayu 
Published: October 2024

Abstract

Background
Hypoglycemia is an acute medical condition that occurs when blood sugar falls below 70 mg/dl. It is a common and potentially life-threatening complication in children with diabetes. Caregivers play a crucial role in managing and caring for their child's diabetes. This study aimed to assess hypoglycemia prevention knowledge, practices, and associated factors among caregivers of diabetic children during follow-up at the Ayder Comprehensive Specialized Hospital Pediatric Endocrinology Clinic in 2024.
Methods
An institutionally based cross-sectional study was carried out between September 2023 and April 2024. A structured questionnaire was used to gather data, and statistical tools for social sciences software, version 25.0, were used for analysis. The dependent and independent variables were tested for relationships via bivariate and multivariate analyses.
Results
Of the 162 enrolled caregivers of diabetic children, 50.6% were mothers, and 81.5% were urban dwellers. In this study, thirty (18.5%) of the caregivers had good knowledge, and sixty-eight (42%) of them had good practices for preventing hypoglycemia. Formal training and education programs were significantly associated with good knowledge (AOR = 17.9, CI: 4.6–70.2). Good hypoglycemia prevention knowledge was significantly associated with hypoglycemia prevention practices (AOR = 0.32; CI: 0.13–0.76).
Conclusion
Knowledge and practices related to hypoglycemia prevention among caregivers of diabetic children were low. Providing formal training and education to caregivers and counseling regarding hypoglycemia during their visit are essential for improving their knowledge and practice in hypoglycemia prevention.
Effect of microwave hydrothermal pretreatment on dissolution of composite components in Acacia wood and subsequent pulping performance
Authors: Ding Weifeng , Ji Xingxiang , Tian Zhongjian , Liu Shan , Zhang Fengshan , Zhou Jingpeng 
Published: October 2024

Abstract

In the field of pulping, the challenge of effectively removing hemicellulose while preserving cellulose has emerged as a critical research issue. To facilitate the extensive development and utilization of Acacia wood as a potential biomass resource, the microwave hydrothermal method was implemented. The results demonstrated that subjecting the material to a 170°C pretreatment for 60 min led to a notable enhancement in hemicellulose dissolution. The total concentration of xylose in the solution reached 15.69 g/L, a value that was considerably higher than that observed in the conventional hydrothermal treatment solution. The regression model constructed using the least squares method is an effective means of predicting the dissolution of composite components under a range of microwave hydrothermal treatment conditions. Furthermore, it was discovered that the pulping process could be optimized by subjecting Acacia wood to lower temperatures (120 ~ 140°C). This resulted in an increase in pulp yield and improvement in paper quality, with an enhancement of 10–20%. In summary, the approach provides new insights into the degradation rule of the composite components in Acacia wood, contributing to the enhancement of subsequent paper-based composite material production, and paving the way for an energy-efficient, sustainable, and environmentally friendly evolution of the pulp and paper industry.
Prevalence and association of sleep duration and different intensities of physical activity with type 2 diabetes: The first evidence from CHARLS
Authors: Zigui Zhou , Xuwen Tian 
Published: October 2024

Abstract

Objectives: The aim of the current study was to examine the prevalence and the independent and joint association between sleep duration and different intensities of physical activity (PA) with type 2 diabetes (T2D) in the China Health and Retirement Longitudinal Study (CHARLS).
Methods: We used data spanning all five years to evaluate the changes in T2D prevalence. Data from 2020 were used to examine the independent and joint associations between sleep duration and different intensities of PA with T2D. Sleep duration was classified into three categories: short (< 6 hours/day), normal (6 - 8 hours/day), and long (> 8 hours/day). PA levels were classified based on the IPAQ recommendations as follows: light-intensity PA (LPA, < 600 MET-minutes/week), moderate-intensity PA (MPA, 600- 3000 MET-minutes/week), and vigorous-intensity PA (VPA, > 3000 MET minutes/week).
Results: The prevalence of T2D in the LPA and short sleep groups increased from 13.35 (95% CI = 10.41 - 16.75) and 11.52 (95% CI = 10.01 - 13.15) in 2011 to 17.27 ( 95% CI = 15.09 - 19.62) and 16.28 (95% CI = 15.34 - 17.25) in 2020, respectively (p< 0.01). Compared with LPA, VPA was associated with lower odds of T2D (OR = 0.80, 95%CI = 0.68 - 0.95). Compared with normal sleep duration, short (OR = 1.19, 95%CI = 1.08 - 1.21) but not long sleep duration (OR = 1.02, 95%CI = 0.85 - 1.22) was more likely to have T2D. The odds of T2D were approximately 40% lower for individuals with LPA and normal sleep duration compared to those with LPA and short sleep duration (OR = 0.65, 95% CI = 0.46 - 0.91). In the MVP groups, combined with any sleep duration, the mitigation effect of exercise on T2D was observed (short: OR = 0.73, 95% CI = 0.56 - 0.95; normal: OR = 0.65, 95% CI = 0.51 - 0.8; long: OR = 0.63, 95% CI = 0.45 - 0.895).
Conclusions: The current study highlights the high prevalence of T2D in the LPA and short sleep groups. Short sleep duration, rather than long sleep duration, was identified as a risk factor for T2D. VPA serve as a protective factor in reducing the high prevalence of T2D associated with sleep disorders.