bluuebunny/crossref_metadata_2025_split huggingface dataset:
Graphdiyne as a promising material for detecting amino acids
Authors: Chen Xi , Gao Pengfei , Guo Lei , Zhang Shengli 
Published: November 2015

AbstractThe adsorption of glycine, glutamic acid, histidine and phenylalanine on single-layer graphdiyne/ graphene is investigated by ab initio calculations. The results show that for each amino acid molecule, the adsorption energy on graphdiyne is larger than the adsorption energy on graphene and dispersion interactions predominate in the adsorption. Molecular dynamics simulations reveal that at room temperature the amino acid molecules keep migrating and rotating on graphdiyne surface and induce fluctuation in graphdiyne bandgap. Additionally, the photon absorption spectra of graphdiyne-amino-acid systems are investigated. We uncover that the presence of amino acid molecules makes the photon absorption peaks of graphdiyne significantly depressed and shifted. Finally, quantum electronic transport properties of graphdiyne-amino-acid systems are compared with the transport properties of pure graphdiyne. We reveal that the amino acid molecules induce distinct changes in the electronic conductivity of graphdiyne. The results in this paper reveal that graphdiyne is a promising two-dimensional material for sensitively detecting amino acids and may potentially be used in biosensors.
Climatic warming and the future of bison as grazers
Authors: Craine Joseph M. , Towne E. Gene , Miller Mary , Fierer Noah 
Published: November 2015

AbstractClimatic warming is likely to exacerbate nutritional stress and reduce weight gain in large mammalian herbivores by reducing plant nutritional quality. Yet accurate predictions of the effects of climatic warming on herbivores are limited by a poor understanding of how herbivore diet varies along climate gradients. We utilized DNA metabarcoding to reconstruct seasonal variation in the diet of North American bison (Bison bison) in two grasslands that differ in mean annual temperature by 6 °C. Here, we show that associated with greater nutritional stress in warmer climates, bison consistently consumed fewer graminoids and more shrubs and forbs, i.e. eudicots. Bison in the warmer grassland consumed a lower proportion of C3 grass, but not a greater proportion of C4 grass. Instead, bison diet in the warmer grassland had a greater proportion of N2-fixing eudicots, regularly comprising >60% of their protein intake in spring and fall. Although bison have been considered strict grazers, as climatic warming reduces grass protein concentrations, bison may have to attempt to compensate by grazing less and browsing more. Promotion of high-protein, palatable eudicots or increasing the protein concentrations of grasses will be critical to minimizing warming-imposed nutritional stress for bison and perhaps other large mammalian herbivores.
Linear monogamy of entanglement in three-qubit systems
Authors: Liu Feng , Gao Fei , Wen Qiao-Yan 
Published: November 2015

AbstractFor any three-qubit quantum systems ABC, Oliveira et al. numerically found that both the concurrence and the entanglement of formation (EoF) obey the linear monogamy relations in pure states. They also conjectured that the linear monogamy relations can be saturated when the focus qubit A is maximally entangled with the joint qubits BC. In this work, we prove analytically that both the concurrence and EoF obey linear monogamy relations in an arbitrary three-qubit state. Furthermore, we verify that all three-qubit pure states are maximally entangled in the bipartition A|BC when they saturate the linear monogamy relations. We also study the distribution of the concurrence and EoF. More specifically, when the amount of entanglement between A and B equals to that of A and C, we show that the sum of EoF itself saturates the linear monogamy relation, while the sum of the squared EoF is minimum. Different from EoF, the concurrence and the squared concurrence both saturate the linear monogamy relations when the entanglement between A and B equals to that of A and C.
Discovery of Novel ROCK1 Inhibitors via Integrated Virtual Screening Strategy and Bioassays
Authors: Shen Mingyun , Tian Sheng , Pan Peichen , Sun Huiyong , Li Dan , Li Youyong , Zhou Hefeng , Li Chuwen , Lee Simon Ming-Yuen , Hou Tingjun 
Published: November 2015

AbstractRho-associated kinases (ROCKs) have been regarded as promising drug targets for the treatment of cardiovascular diseases, nervous system diseases and cancers. In this study, a novel integrated virtual screening protocol by combining molecular docking and pharmacophore mapping based on multiple ROCK1 crystal structures was utilized to screen the ChemBridge database for discovering potential inhibitors of ROCK1. Among the 38 tested compounds, seven of them exhibited significant inhibitory activities of ROCK1 (IC50 < 10 μM) and the most potent one (compound TS-f22) with the novel scaffold of 4-Phenyl-1H-pyrrolo [2,3-b] pyridine had an IC50 of 480 nM. Then, the structure-activity relationships of 41 analogues of TS-f22 were examined. Two potent inhibitors were proven effective in inhibiting the phosphorylation of the downstream target in the ROCK signaling pathway in vitro and protecting atorvastatin-induced cerebral hemorrhage in vivo. The high hit rate (28.95%) suggested that the integrated virtual screening strategy was quite reliable and could be used as a powerful tool for identifying promising active compounds for targets of interest.
Endochondral ossification pathway genes and postmenopausal osteoporosis: Association and specific allele related serum bone sialoprotein levels in Han Chinese
Authors: Zhang Yunzhi , Liu Haiyan , Zhang Chen , Zhang Tianxiao , Zhang Bo , Li Lu , Chen Gang , Fu Dongke , Wang KunZheng 
Published: November 2015

AbstractOsteoporosis is a systemic skeletal disorder characterized by reduced bone mineral density (BMD) and disrupted bone architecture, predisposing the patient to increased fracture risk. Evidence from early genetic epidemiological studies has indicated a major role for genetics in the development of osteoporosis and the variation in BMD. In this study, we focused on two key genes in the endochondral ossification pathway, IBSP and PTHLH. Over 9,000 postmenopausal Han Chinese women were recruited and 54 SNPs were genotyped. Two significant SNPs within IBSP, rs1054627 and rs17013181, were associated with BMD and postmenopausal osteoporosis by the two-stage strategy and rs17013181 was also significantly associated with serum IBSP levels. Moreover, one haplotype (rs12425376-rs10843047-rs42294) covering the 5’ end of PTHLH was associated with postmenopausal osteoporosis. Our results provide evidence for the association of these two key endochondral ossification pathway genes with BMD and osteoporosis in postmenopausal Han Chinese women. Combined with previous findings, we provide evidence that a particular SNP in IBSP has an allele-specific effect on mRNA levels, which would, in turn, reflect serum IBSP levels.
Formononetin promotes angiogenesis through the estrogen receptor alpha-enhanced ROCK pathway
Authors: Li Shang , Dang Yuanye , Zhou Xuelin , Huang Bin , Huang Xiaohui , Zhang Zherui , Kwan Yiu Wa , Chan Shun Wan , Leung George Pak Heng , Lee Simon Ming Yuen , Hoi Maggie Pui Man 
Published: November 2015

AbstractFormononetin is an isoflavone that has been shown to display estrogenic properties and induce angiogenesis activities. However, the interrelationship between the estrogenic properties and angiogenesis activities of formononetin are not well defined. In the present study, docking and enzymatic assay demonstrated that formononetin displayed direct binding to the ligand-binding domain (LBD) of estrogen receptor alpha (ERα) with an agonistic property. Results from Human Umbilical Vein Endothelial Cells (HUVEC) by using real-time migration xCELLigence system, immunofluorescence and western blotting provided strong evidences of formononetin induced endothelial cell migration and dramatic actin cytoskeleton spatial modification through ERα-enhanced-ROCK-II/MMP2/9 signaling pathways. In addition, results from co-immunoprecipitation suggested formononetin induced cell migration via recruiting of ERα/ROCK-II activated complex formation. More interestingly, in zebrafish embryo we observed that formononetin significantly promoted angiogenic sproutings in the subintestinal vessels (SIVs) that could be completely abolished by ROCK inhibitor. In this study, we elucidated the underlying mechanisms that formononetin produced proangiogenesis effects through an ERα-enhanced ROCK-II signaling pathways. Results from the present study also expand our knowledge about the enigmatic underlying mechanisms of phytoestrogenic compounds in the promotion of angiogenesis in relation to ERα and ROCK interaction in endothelial cells and their relationship with actin assembly and cell migration.
Regulation of formation of volatile compounds of tea (Camellia sinensis) leaves by single light wavelength
Authors: Fu Xiumin , Chen Yiyong , Mei Xin , Katsuno Tsuyoshi , Kobayashi Eiji , Dong Fang , Watanabe Naoharu , Yang Ziyin 
Published: November 2015

AbstractRegulation of plant growth and development by light wavelength has been extensively studied. Less attention has been paid to effect of light wavelength on formation of plant metabolites. The objective of this study was to investigate whether formation of volatiles in preharvest and postharvest tea (Camellia sinensis) leaves can be regulated by light wavelength. In the present study, in contrast to the natural light or dark treatment, blue light (470 nm) and red light (660 nm) significantly increased most endogenous volatiles including volatile fatty acid derivatives (VFADs), volatile phenylpropanoids/benzenoids (VPBs) and volatile terpenes (VTs) in the preharvest tea leaves. Furthermore, blue and red lights significantly up-regulated the expression levels of 9/13-lipoxygenases involved in VFADs formation, phenylalanine ammonialyase involved in VPBs formation and terpene synthases involved in VTs formation. Single light wavelength had less remarkable influences on formation of volatiles in the postharvest leaves compared with the preharvest leaves. These results suggest that blue and red lights can be promising technology for remodeling the aroma of preharvest tea leaves. Furthermore, our study provided evidence that light wavelength can activate the expression of key genes involved in formation of plant volatiles for the first time.
Enhanced

drift effects in the TCV snowflake divertor
Authors: Canal G.P. , Lunt T. , Reimerdes H. , Duval B.P. , Labit B. , Vijvers W.A.J. 
Published: November 2015

Abstract
Measurements of various plasma parameters at the divertor targets of snowflake (SF) and conventional single-null configurations indicate an enhanced effect of the

drift in the scrape-off layer of plasmas in the SF configuration. Plasma boundary transport simulations using the EMC3-Eirene code show that the poloidal gradients of the kinetic profiles in the vicinity of the null-point of a SF divertor are substantially larger than those of a conventional single-null configuration. These gradients are expected to drive larger

flows in the SF divertor and are thought to be responsible for the formation of the double-peaked particle and heat flux target profiles observed experimentally. Experiments in forward and reversed toroidal magnetic field directions further support this conclusion. The formation of such a double-peaked profiles is enhanced at higher plasma densities and may have beneficial effects on the divertor heat loads since they lead to broader target profiles and lower peak heat fluxes.
Greater understanding is need of whether warmer and shorter winters associated with climate change could reduce winter mortality
Authors: Ebi Kristie L 
Published: November 2015

Abstract
In temperate regions, mortality is higher during winter than summer seasons. Assuming this seasonality is associated with ambient temperature, assessments often conclude that climate change will likely reduce winter mortality. However, there has been limited evaluation of the extent to which cold temperatures are actually the proximal cause of winter mortality in temperate regions. Kinney et al (2015 Environ Res. Lett.

10 064016) analyzed multi-decadal data from 39 cities in the US and France and concluded that cold temperatures are not a primary driver of most winter excess mortality. These analyses suggest that increases in heat-related mortality with climate change will unlikely be balanced by reductions in winter mortality, reinforcing the importance of health systems continuing to ensure adequate health protection against cold temperatures even as temperatures warm.
The Gradual Increase of Responsibility Model for coaching teachers
Authors: Collet Vicki S. 
Published: November 2015

Purpose– This collective case study investigated the ways in which coaching supports teacher change. Specifically, the purpose of this paper is to consider what types of feedback are best at what times in the coaching process and how coaching supports teachers’ application of learning to differing contexts.Design/methodology/approach– The study was conducted over an 18-month period in three settings: a university reading clinic and two schools. Participants were a coach and two in-service teachers enrolled in a literacy specialist master’s degree program. This qualitative study included observational field notes, interviews, lesson plans, and teacher reflections as primary data sources.Findings– Findings suggest a model for coaching that acknowledges the learner’s previous knowledge and experience and continuously gauges support to stay within the ever-escalating zone of proximal development. Specific coaching moves that vary by degree of scaffolding are identified, namely: modeling, recommending, asking questions, affirming, and praising.Research limitations/implications– This study clarifies the varying roles that coaches may play and how these roles change over time. Additionally, the model has implications for how coaching might change based on variability among those being coached.Originality/value– The Gradual Increase of Responsibility Model has potential to guide coaches as they engage with mentees to improve instruction.
Mentoring pathways to enhancing the personal and professional development of pre-service teachers
Authors: Grima-Farrell Christine 
Published: November 2015

Purpose
– The purpose of this paper is to examine the critical features and outcomes of an Australian collaborative university- and school-based immersion project for mentoring final year pre-service primary teachers in the area of special education as they embed theory and practice in inclusive classrooms for a full year, to respond to diverse student needs.

Design/methodology/approach
– Using a three-year qualitative study design, data were gathered through pre surveys and post surveys, two one-to-one semi-structured interviews, and reflexive journal entries. Analysis using triangulation of data sources and inter-rater reliability was employed to reach consensus on the key themes.

Findings
– Findings suggest that mentors proved critical to reducing pre-service teacher anxieties and to enhancing their personal and professional knowledge, confidence and skills as they differentiated instruction and assessment techniques to cater for students with a diverse range of abilities.

Research limitations/implications
– This research suggests that maintaining the balance of theory and practice through genuine extended school engagement experiences provided opportunities for collaborative connections on multiple levels across the school. This mentoring pathway enhanced and reinforced pre-service teachers’ professional capacity, confidence and employability potential. Limitations such as small sample size and lack of secondary school representation must be noted.

Originality/value
– This work identified the importance of the unique features of a mentoring programme within a university-school partnership, including the benefits of a full-year immersion experience, financial reward, responsibility, empowerment and enhanced employability status of final year pre-service teachers as they transition to classroom teachers. This paper provides useful insights for researchers, practitioners and teacher education policy developers.
Customer returns model in a dual-channel supply chain
Authors: Yang Feng , Hu Pei , Zhao Fuguo , Hu Cuihua 
Published: November 2015

Purpose
– The purposes of this paper is to propose a customer returns model in a dual-channel supply chain where a customer can return the purchased product to the retailer or the manufacturer and obtain an equilibrium of selling prices and refund prices and the optimal profit when considering customer returns in the centralized and decentralized dual-channel supply chain.

Design/methodology/approach
– This paper mainly uses the game theory technique to analyze the problem. The manufacturer and the retailer are vertically integrated in the traditional channel, and the results of the centralized dual-channel supply chain are obtained. Then, the Stackelberg game was adopted to analyze the decentralized dual-channel supply chain. Finally, the detailed numerical simulation is proposed to obtain straight-forward insights for the industrial managers.

Findings
– The mathematic analysis used shows that the main findings of this paper are: in the centralized scenario, the retailer and the manufacturer will charge higher selling prices when they offer return policy, and the demand for each channel increases, which results in higher profit; and the price and refund price of the direct channel in the centralized and decentralized dual-channel are the same, respectively.

Originality/value
– Most previous literatures highlight that return policy plays an important role in supply chain which considering one channel. But there is no study on the customer return policy in dual-channel supply chain. This paper is a further step to model the effects of customer returns policy on the pricing policy and optimize the profits in a dual-channel supply chain. This paper analyzes the pricing and refund strategies and gets an equilibrium in the centralized and decentralized dual-channel supply chain scenarios.
A literature review on lot size with quantity discounts: 1995-2013
Authors: Pereira Valdecy , Costa Helder Gomes 
Published: November 2015

Purpose
– This paper aims to present a literature review on models developed for the economic order quantity (EOQ) problem with incremental and all-units discounts, extending the work of Benton and Park (1996) which covered the most significant literature, from 1963 to 1994, about EOQ with discounts and that has identified four open areas in this field of study. The modeling of lot size with discounts wishes to give good solutions for realistic situations, such as those concerning the discounts offered by suppliers, to rises in the demand.

Design/methodology/approach
– The research was carried out in papers published from 1995 to 2013, and indexed in databases as Scopus and ISI Web of Science. The papers were compared through objective function, constraints, discounts, developed algorithms, allowance of shortages or multiproduct, demand pattern and buyer or buyer–supplier perspective.

Findings
– Results indicate two areas that still remain untouched, and probably the main cause is due to mathematical complexities. The authors have also identified an increasing trend of works that compared just-in-time with the EOQ with quantity discounts policy and also an increasing number of works that solved this category of problems with algorithms.

Research limitations/implications
– The research does not cover materials published in working papers, monographs, thesis, conferences or journals that are not indexed in those databases.

Originality/value
– This manuscript fills a gap in the study of EOQ with incremental discounts, as it highlights the leading edge advances in this field and the main differences among models. As a whole, the new trends about modeling EOQ problems with quantity discounts were discovered.
Aggregate production planning with learning effect and uncertain demand
Authors: Chen Zhixiang , Sarker Bhaba  R. 
Published: November 2015

Purpose
– The purpose of this paper is to study the impact of learning effect and demand uncertainty on aggregate production planning (APP), provide practitioners with some important managerial implications for improving production planning and productivity.

Design/methodology/approach
– Motivated by the background of one labour-intensive manufacturing firm – a mosquito expellant factory – an APP model considering workforce learning effect and demand uncertainty is established. Numerical example and comparison with other two models without considering learning and uncertainty of demand are conducted.

Findings
– The result shows that taking into account the uncertain demand and learning effect can reduce total production cost and increase flexibility of APP.

Practical implications
– Managerial implications are provided for practitioners with four propositions on improving workforce learning effect, i.e. emphasizing employee training, combing individual and organizational learning and reduction of forgetting effect.

Originality/value
– This paper has practice value in improving APP in labor-intensive manufacturing.
Shifting the burden archetype: developing a system dynamics game
Authors: Bagodi Virupaxi , Mahanty Biswajit 
Published: November 2015

Purpose
– The purpose of the paper is to demonstrate the short comings in decision-making in a complex system. An approach to coping with a complex decision-making task is to identify generic structures known as systems archetypes in a given decision situation. In the “shifting the burden” archetype, decision-makers fail to identify the fundamental solution early and are subjected to accumulated side effects as they resort to quick remedial solutions.

Design/methodology/approach
– A system dynamics-based game has been built to highlight the pitfalls of “shifting the burden” systems archetype for a decision-making situation in the Indian two-wheeler industry. Participants of the game make strategic decisions for a company and receive feedback of their decisions and corresponding actions after every plan period.

Findings
– The decision-makers who adopt short-term measures to alleviate the company’s problems, invariably fail in their endeavour. Success comes to those who realize the importance of having a long-term perspective in the form of pursuing fundamental solutions.

Practical implications
– What could be a possible way of avoiding the pitfalls? The decision-makers should be aware of the pitfalls beforehand and identify the same – a decision support system possibly can aid them in this regard.

Originality/value
– The complexity of the system increases as the business grows. The managers need to adopt systems thinking and embrace a long-term perspective. Decision support systems integrating models of systems archetypes provide an environment to simulate various decision situations and see the effects beforehand.