bluuebunny/crossref_metadata_2025_split huggingface dataset:
Overall and domain‐specific life satisfaction when living with familial Alzheimer's disease risk: A quantitative approach
Authors: Bergman Mette , Graff Caroline , Eriksdotter Maria , Schuster Marja , Fugl‐Meyer Kerstin S. 
Published: August 2017

AbstractIn this study, we explored life satisfaction and sense of coherence in relation to biopsychosocial variables in individuals at risk for the development of familial Alzheimer's disease. Forty nine individuals (response rate: 96%) were interviewed. Life satisfaction was found to be high for the majority of participants. Those who were older than the expected age of onset of disease, those <6 years’ inclusion in the Familial Alzheimer's disease biomarker study, and males tended to experience positive psychological health. Sense of coherence was positively associated with satisfaction with life as a whole, psychological health, vocation, and economy. Women seem to be more vulnerable than men, and attention should be given to those who have not passed the age of expected symptom onset. Early and recurrent counseling and psychosocial support were found to be essential. Issues related to vocation and economy are areas of concern, and are closely associated with sense of coherence, life satisfaction, and psychological health. This study emphasizes the importance of professional teams working together with the patient and their families.
Brassinosteroid‐mediated apoplastic H2O2‐glutaredoxin 12/14 cascade regulates antioxidant capacity in response to chilling in tomato
Authors: Xia Xiao‐Jian , Fang Ping‐Ping , Guo Xie , Qian Xiang‐Jie , Zhou Jie , Shi Kai , Zhou Yan‐Hong , Yu Jing‐Quan 
Published: August 2017

AbstractBrassinosteroids (BRs) regulate plant development and stress response. Although much has been learned about their roles in plant development, the mechanisms by which BRs regulate plant stress tolerance remain unclear. Chilling is a major stress that adversely affects plant growth. Here, we report that BR positively regulates chilling tolerance in tomato. BR partial deficiency aggravated chilling‐induced oxidized protein accumulation, membrane lipid peroxidation, and decrease of maximum quantum efficiency of photosystem II (Fv/Fm). By contrast, overexpression of BR biosynthetic gene Dwarf or treatment with 24‐epibrassinolide (EBR) attenuated chilling‐induced oxidative damages and resulted in an increase of Fv/Fm. BR increased transcripts of RESPIRATORY BURST OXIDASE HOMOLOG1 (RBOH1) and GLUTAREDOXIN (GRX) genes, and BR‐induced chilling tolerance was associated with an increase in the ratio of reduced/oxidized 2‐cysteine peroxiredoxin (2‐Cys Prx) and activation of antioxidant enzymes. However, RBOH1‐RNAi plants failed to respond to EBR as regards to the induction of GRX genes, activation of antioxidant capacity, and attenuation of chilling‐induced oxidative damages. Furthermore, silencing of GRXS12 and S14 compromised EBR‐induced increases in the ratio of reduced/oxidized 2‐Cys Prx and activities of antioxidant enzymes. Our study suggests that BR enhances chilling tolerance through a signalling cascade involving RBOH1, GRXs, and 2‐Cys Prx in tomato.
The effect of category learning on visual attention and visual representation
Authors: Folstein Jonathan R. , Monfared Shamsi S. , Maravel Trevor 
Published: August 2017

AbstractSubordinate‐level category learning recruits neural resources associated with perceptual expertise, including the N250 component of the ERP, a posterolateral negative wave maximal between 230 and 330 ms. The N250 is a relatively late visual ERP and could plausibly be driven by attention to the features of categorized objects. Indeed, it has a latency and scalp distribution similar to the selection negativity (SN), an ERP component long known to be sensitive to attentional selection of target features. To clarify sensitivity of the N250 to attention and to more generally investigate the effect of category learning on attentional modulation of learned features, we independently manipulated subordinate‐level category learning and target detection in a speeded paradigm designed to optimally elicit the SN and accompanying frontal selection positivity (FSP). Participants first practiced categorizing a set of artificial animal stimuli and then performed a speeded target detection task on trained and untrained stimuli while ERPs were recorded. SN and FSP were roughly linearly related to the number of target features in the stimulus. Trained stimuli elicited a significantly larger N250 than untrained stimuli. The SN and N250 effects were additive, with all levels of target similarity equally affected by training, and had different time courses. Training had little effect on the FSP. The results suggest that (a) the N250 and SN have different sources, and (b) at the very least, the learning‐induced N250 indexes a different attentional subprocess from the target‐induced SN and could be driven by a different cognitive process altogether.
Multidimensional assessment of severe asthma: A systematic review and meta‐analysis
Authors: Clark Vanessa L. , Gibson Peter G. , Genn Grayson , Hiles Sarah A. , Pavord Ian D. , McDonald Vanessa M. 
Published: August 2017

ABSTRACTThe management of severe asthma is complex. Multidimensional assessment (MDA) of specific traits has been proposed as an effective strategy to manage severe asthma, although it is supported by few prospective studies.We aimed to systematically review the literature published on MDA in severe asthma, to identify the traits included in MDA and to determine the effect of MDA on asthma‐related outcomes.We identified 26 studies and classified these based on study type (cohort/cross‐sectional studies; experimental/outcome studies; and severe asthma disease registries). Study type determined the comprehensiveness of the assessment. Assessed traits were classified into three domains (airways, co‐morbidities and risk factors). The airway domain had the largest number of traits assessed (mean ± SD = 4.2 ± 1.7) compared with co‐morbidities (3.6 ± 2.2) and risk factors (3.9 ± 2.1). Bronchodilator reversibility and airflow limitation were assessed in 92% of studies, whereas airway inflammation was only assessed in 50%. Commonly assessed co‐morbidities were psychological dysfunction, sinusitis (both 73%) and gastro‐oesophageal reflux disease (GORD; 69%). Atopic and smoking statuses were the most commonly assessed risk factors (85% and 86%, respectively).There were six outcome studies, of which five concluded that MDA is effective at improving asthma‐related outcomes. Among these studies, significantly more traits were assessed than treated.MDA studies have assessed a variety of different traits and have shown evidence of improved outcomes. This promising model of care requires more research to inform which traits should be assessed, which traits should be treated and what effect MDA has on patient outcomes.
A pilot study of the effect of pullulan‐conjugated Der f 2 allergen‐specific immunotherapy on canine atopic dermatitis
Authors: Kawano Kouji , Mizuno Takuya 
Published: August 2017

BackgroundDermatophagoides farinae is a major and common environmental house dust mite involved in canine atopic dermatitis (CAD). A formulation of recombinant protein Der f 2 is available in Japan for immunotherapy in dogs.Hypothesis/ObjectivesTo evaluate the efficacy of a recombinant allergen based on Der f 2‐pullulan for the treatment of cAD.MethodsDogs (n = 15) with atopic dermatitis were administered Der f 2 conjugated with pullulan (‐P). Two dogs were eliminated because of death unrelated to the treatment during the study. The remaining 13 cases were included in the analysis. Clinical signs were evaluated with the Canine Atopic Dermatitis Lesion Index (CADLI) and pruritus levels were evaluated from 0 to 10 with a pruritus Visual Analog Scale (PVAS).ResultsThe mean ± standard deviation (SD) of CADLI [before allergen‐specific immunotherapy (pre‐ASIT) 21.9 ± 9.7; 60 days post‐ASIT 9.8 ± 8.4 and 120 days post‐ASIT 9.7 ± 8.2] and the mean ± SD of PVAS [pre‐ASIT 7.2 ± 1.2; post‐ASIT (60 days) 2.6 ± 2.2 and post‐ASIT (120 days) 3.1 ± 2.5] significantly decreased after treatment (Dunnett's test, P < 0.05). Furthermore, the total doses of oral glucocorticoids in the two months pre‐ASIT significantly decreased in comparison with two months post‐ASIT (123 ± 72.6 mg vs. 70.0 ± 84.3 mg; Dunnett's test, P < 0.05).Conclusions and clinical importanceThe results indicate the effectiveness of Der f 2‐P recombinant protein in the treatment of dogs with CAD and testing positive to D. farinae.
Draft Genome Sequences of Salmonella enterica Serovar Typhimurium LT2 with Deleted Chitinases That Are Emerging Virulence Factors
Authors: Arabyan Narine , Huang Bihua C. , Weimer Bart C. 
Published: August 2017

ABSTRACT

Chitinases are glycosyl hydrolases that catalyze the hydrolysis of the β-1,4 linkages in complex carbohydrates and those that contain GlcNAc. These enzymes are considered emerging virulence factors during infection because the host glycan changes. This is the release of four single chitinase deletion mutants in
Salmonella enterica
serovar Typhimurium LT2.
Whole-Genome Sequence of Leuconostoc mesenteroides LT-38, a Non-Spore-Forming Gram-Positive Lactic Acid Bacterium
Authors: Kato Shiro , Oikawa Tadao 
Published: August 2017

ABSTRACT

The present study reports the complete genome sequence of
Leuconostoc mesenteroides
strain LT-38, which is a non-spore-forming Gram-positive lactic acid bacterium. The genome is composed of a 2,022,184-bp circular chromosome and contains 2,005 putative protein-coding genes.
Complete Genome Sequence of
Stenotrophomonas
sp. Strain WZN-1, Which Is Capable of Degrading Polybrominated Diphenyl Ethers
Authors: Wu Zhineng , Bartlam Mark , Wang Yingying 
Published: August 2017

ABSTRACT

Stenotrophomonas
sp. strain WZN-1, isolated from an e-waste recycling area in Tianjin, China, is capable of degrading polybrominated diphenyl ethers (PBDEs). The complete genome of strain WZN-1 consists of 4,512,703 bp. This genome information will provide important information about the biodegradation pathways and mechanisms of PBDEs.
Draft Genome Sequence of Cronobacter sakazakii GP1999, Sequence Type 145, an Epiphytic Isolate Obtained from the Tomato’s Rhizoplane/Rhizosphere Continuum
Authors: Chase Hannah R. , Eberl Leo , Stephan Roger , Jeong HyeJin , Lee Chaeyoon , Finkelstein Samantha , Negrete Flavia , Gangiredla Jayanthi , Patel Isha , Tall Ben D. , Gopinath Gopal R. , Lehner Angelika 
Published: August 2017

ABSTRACT

We present here the draft genome of
Cronobacter sakazakii
GP1999, a sequence type 145 strain isolated from the rhizosphere of tomato plants. Assembly and annotation of the genome resulted in a genome of 4,504,670 bp in size, with 4,148 coding sequences, and a GC content of 56.8%.
Draft Genome Sequence of an Endophytic Fungus,
Gaeumannomyces
sp. Strain JS-464, Isolated from a Reed Plant,
Phragmites communis
Authors: Kim Jung A. , Jeon Jongbum , Kim Ki-Tae , Choi Gobong , Park Sook-Young , Lee Hyun-Jung , Shim Sang-Hee , Lee Yong-Hwan , Kim Soonok 
Published: August 2017

ABSTRACT

An endophytic fungus,
Gaeumannomyces
sp. strain JS-464, is capable of producing a number of secondary metabolites which showed significant nitric oxide reduction activity. The draft genome assembly has a size of 53,151,282 bp, with a G+C content of 53.11% consisting of 80 scaffolds with an
N
50
of 7.46 Mbp.
Exploring the patient perspective of fatigue in adults with visual impairment: a qualitative study
Authors: Schakel Wouter , Bode Christina , van der Aa Hilde P A , Hulshof Carel T J , Bosmans Judith E , van Rens Gerardus H M B , van Nispen Ruth M A 
Published: August 2017

ObjectivesFatigue is an often mentioned symptom by patients with irreversible visual impairment. This study explored the patient perspective of fatigue in visually impaired adults with a focus on symptoms of fatigue, causes, consequences and coping strategies.SettingTwo large Dutch low vision multidisciplinary rehabilitation organisations.Participants16 visually impaired adults with severe symptoms of fatigue selected by purposive sampling.MethodsA qualitative study involving semistructured interviews. A total of four first-level codes were top–down predetermined in correspondence with the topics of the research question. Verbatim transcribed interviews were analysed with a combination of a deductive and inductive approach using open and axial coding.ResultsParticipants often described the symptoms of fatigue as a mental, daily and physical experience. The most often mentioned causes of fatigue were a high cognitive load, the intensity and amount of activities, the high effort necessary to establish visual perception, difficulty with light intensity and negative cognitions. Fatigue had the greatest impact on the ability to carry out social roles and participation, emotional functioning and cognitive functioning. The most common coping strategies were relaxation, external support, socialising and physical exercise and the acceptance of fatigue.ConclusionsOur results indicate that low vision-related fatigue is mainly caused by population specific determinants that seem different from the fatigue experience described in studies with other patient populations. Fatigue may be central to the way patients react, adapt and compensate to the consequences of vision loss. These findings indicate a need for future research aimed at interventions specifically tailored to the unique aspects of fatigue related to vision loss.
A randomised trial of non-mydriatic ultra-wide field retinal imaging versus usual care to screen for diabetic eye disease: rationale and protocol for the Clearsight trial
Authors: Liu Selina L , Mahon Lewis W , Klar Neil S , Schulz David C , Gonder John R , Hramiak Irene M , Mahon Jeffrey L 
Published: August 2017

IntroductionSuboptimal screening for diabetic eye disease is a major cause of preventable vision loss. Screening barriers include mydriasis and the extra time patients need to attend dedicated eye screening appointments. In the Clearsight trial, we are testing whether screening by non-mydriatic ultra-wide field (NM UWF) imaging on the day patients attend their diabetes outpatient clinic visit improves detection of clinically important eye disease compared with usual screening.Methods and analysisPatients with diabetes due for a screening eye exam by the 2013 Canadian Diabetes Association (CDA) practice guidelines are being randomised to on-site screening by NM UWF imaging on the day of their clinic visit or to usual screening where, per CDA guidelines, they are encouraged to arrange an exam by an optometrist. The primary outcome is actionable eye disease (AED) based on a need for referral to ophthalmology and/or increased ocular surveillance. The primary analysis will use an intention-to-screen approach that compares the proportions of detected AED between on-site and usual screening groups under a superiority hypothesis in favour of on-site screening. With 740 randomised participants, the study will have 80% power to detect ≥5% absolute increase in the AED rate among on-site screening versus usual screening participants. This difference translates into a number-needed-to-screen by on-site screening of 20 to detect 1 additional person with AED.Ethics and disseminationThe protocol was approved by the institutional review board of Western University. The findings of the trial will be disseminated directly to participants and through peer-reviewed publications and conference presentations.Trial registration numberClinicalTrials.GovNCT02579837(registered 16 October 2015).Protocol issue date18 November 2015.
Examining the mediating effect of work-to-family conflict on the associations between job stressors and employee psychological distress: a prospective cohort study
Authors: Oshio Takashi , Inoue Akiomi , Tsutsumi Akizumi 
Published: August 2017

ObjectivesThe mediating effect of work-to-family conflict (WFC) on the associations between eight types of job stressors (measured based on the job demands-control, effort–reward imbalance and organisational justice models) and psychological distress in employees was examined.DesignThis study employed a prospective design.SettingAn occupational cohort study in Japan (Japanese Study of Health, Occupation, and Psychosocial Factors Related Equity; J-HOPE).Participants5859 men and 1560 women who were working for 11 firms and participated at three consecutive waves of J-HOPE, at 1-year intervals, from 2010 to 2013.Main outcome measuresPsychological distress, as measured by Kessler 6 scores.ResultsMediation analysis using data on job stressors at baseline, WFC at 1-year follow-up and psychological distress at 2-year follow-up showed that WFC mediated 39.1% (95% CI 29.1% to 49.1%) and 44.5% (95% CI 31.4% to 51.7%) of the associations of psychological distress with job demands and effort, respectively, for men. The mediating effect of WFC was smaller for job stressors indicating reduced job resources, compared with job demands and effort. The mediating effect of WFC was somewhat larger for women than it was for men, with WFC mediating 47.5% (95% CI 22.5% to 72.6%) and 64.0% (95% CI 24.3% to 100.0%) of the associations of psychological distress with job demands and effort, respectively.ConclusionsWFC was a key mediator in the associations between most job stressors and employee psychological distress. Results suggest that policy measures and support from supervisors, to prevent job stressors from adding to WFC, are needed to reduce employee psychological distress.
A qualitative study of pregnancy-related anxiety among women in Tanzania
Authors: Rosario Melanie King , Premji Shahirose Sadrudin , Nyanza Elias Charles , Bouchal Shelley Raffin , Este David 
Published: August 2017

ObjectivesTo explore and understand the experiences and priorities of pregnant women living with fears and worries related to fetal/infant and maternal health, the birthing process and ability to parent the infant (ie, pregnancy-related anxiety (PRA)) in Mwanza, Tanzania.DesignDescriptive phenomenological approach.SettingTwo clinics in the Ilemela and Nyamagana districts of Mwanza.ParticipantsPregnant and postpartum women who obtained high scores on a PRA scale during pregnancy in a larger quantitative study were contacted to participate in an interview (10 women, aged 18–34 years; 3 HIV positive).MeasuresSemi-structured interviews were undertaken, with guiding questions related to the women's experience during pregnancy. The Colaizzi method was used with transcripts that had been translated and back translated from Swahili to English and then hand-coded by the interviewer, with independent review by another researcher to verify the analysis.ResultsPRA, as experienced by women in Mwanza, was a state of worry and concern, often causing physical symptoms, and disrupting personal sense of peace. While some themes in the women's experiences reflected the domains examined in the PRA scale used to identify potential participants, others such as lack of knowledge, partner relationship, interactions with the healthcare system, spirituality and fear of HIV/AIDS were otherwise missing. Their prominence in the participants’ stories broadens our understanding of PRA.ConclusionsThe realities and viewpoints of women in low-income and middle-income countries (LMIC) experiencing PRA are still relatively unknown. The findings from this study provided much-needed insight into the perspectives and priorities of women in Mwanza who have experienced PRA and further support the need to explore this phenomenon in other LMIC. The additional domains identified reinforce the need for a PRA tool that accurately and adequately capture the complexities of PRA for women in this region.
Identifying vulnerable populations to death and injuries from residential fires
Authors: Gilbert Stanley W , Butry David T 
Published: August 2017

ObjectiveThis study proposes and evaluates the theory that people who are susceptible to injury in residential fires are not susceptible to death in residential fires and vice versa. It is proposed that the population vulnerable to death in residential fires can be proxied by ‘frailty’, which is measured as age–gender adjusted fatality rates due to natural causes.MethodsThis study uses an ecological approach and controls for exposure to estimate the vulnerability of different population groups to death and injury in residential fires. It allows fatalities and injuries to be estimated by different models.ResultsFrailty explains fire-related death in adults while not explaining injuries, which is consistent with the idea that deaths and injuries affect disjoint populations.ConclusionsDeaths and injuries in fire are drawn from different populations. People who are susceptible to dying in fires are unlikely to be injured in fires, and the people who are susceptible to injury are unlikely to die in fires.
The LHC upper bounds for pp → diboson, tt̄ cross-section on fermionic dark matter
Authors: Ghorbani Karim , Ghorbani Parsa Hossein 
Published: August 2017

The ATLAS report in August 2016 provided an upper limit for the pp[Formula: see text][Formula: see text][Formula: see text]diboson and [Formula: see text] cross-sections. We consider a pseudoscalar-mediated fermionic dark matter together with gluon and photon effective operators interacting with the pseudoscalar. Choosing the resonance mass being [Formula: see text], 750 GeV and 2 TeV, beside the relic density and the invisible Higgs decay constraints we constrain more the space of parameters with the diboson and [Formula: see text] cross-section upper bounds. We finally provide some benchmarks consistent with all the constraints. Having exploited a pseudoscalar mediator, the DM-nucleon cross-section is velocity suppressed so that the model evades easily the bounds put by the future direct detection experiments such as XENON1T.
Volar Tenodesis for the Treatment of Swan-neck Deformity; A Systematic Review
Authors: Kiziridis Georgios , Giddins Grey E.B. 
Published: August 2017

Background: Swan-neck deformity is a common problem particularly in patients with Rheumatoid arthritis. Mobile swan-neck deformities (Nalebuff types I,II) can be treated non-operatively and operatively. In this paper we report on a systematic review of the treatment of swan-neck deformities with volar tenodesis.Methods: We performed a literature search and analysed the literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only eight papers were eligible. None was of high quality. The data reporting was very variable. Therefore, no meta-analysis could be performed, but only a descriptive analysis.Results: The techniques work in preventing proximal inter-phalangeal joint hyperextension between 60 and 100% in these studies. There appears to be some recurrence of hyper-extension with time so that papers with longer follow-up tend to have poorer results.Conclusions: There is no good evidence that one technique is superior to another. The choice of technique is likely to remain based on surgeon preference for the foreseeable future. Future studies should be at least comparative and preferably part of a trial.