bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone mineral density utilization in patients with newly diagnosed multiple myeloma
Authors: Muchtar Eli , Dagan Adi , Robenshtok Eyal , Shochat Tzippy , Oniashvili Nino , Amitai Irina , Raanani Pia , Magen Hila 
Published: June 2016

AbstractBone disease is a major cause for morbidity in multiple myeloma (MM), with the main focus concerning the manifestation as osteolytic lesions. Bone mineral loss is another reflection of myeloma bone involvement. Recently, osteoporosis has been omitted as a defining criterion for symptomatic disease in MM. We conducted a retrospective study to evaluate the use of bone mineral density (BMD) exams by dual‐energy X‐ray absorptiometry (DXA) among MM patients in a tertiary medical care centre. One‐hundred seventy three patients were included. The T‐scores of lumbar spine (LS), left femur neck (FN) and left total hip (TH) were obtained and analysed. The extent of osteolytic disease was categorized based on six bony areas. There was a strong correlation between spine and femur's T‐scores (r = 0.56–0.61, p < 0.0001), although different sets of variables were correlated with LS and femur's T‐scores. There was no correlation between BMD measurements and osteolytic disease extent. Patients with vertebral fracture(s) had significant lower T‐scores of the spine in comparison to patients without vertebral fractures. Sixty‐three patients (36.4% of the cohort) had follow‐up DXA exam. In general, there was an increase in the LS T‐scores, while femoral values decreased. However, in patients who achieved complete response (CR) and in those who retained CR during follow‐up, femoral BMD increased as well. Because correlation between BMD and the extent of osteolytic lesions was not seen, our data support the recent exclusion of BMD assessment from the definition of symptomatic myeloma. Still, its use should be considered for evaluation of age‐ or therapy‐related osteoporosis. Copyright © 2016 John Wiley & Sons, Ltd.
MATERNAL GRIEVING AND THE PERCEPTION OF AND ATTACHMENT TO CHILDREN BORN SUBSEQUENT TO A PERINATAL LOSS
Authors: Al‐Maharma Dua’ Yousef , Abujaradeh Hiba , Mahmoud Khadejah Fahmi , Jarrad Reem Ahmad 
Published: June 2016

ABSTRACTThe purpose of this study was to examine the relationship between maternal grieving for perinatal loss (PL) and the perception of and attachment to children born subsequent to a recent PL among mothers in Jordan. A cross‐sectional, descriptive correlational design was used. A convenience sample of 190 mothers of full‐term, healthy newborns born subsequent to a recent PL was recruited from seven Maternal and Child Health Care Centers in Jordan. These mothers were assessed using the Perinatal Grief Scale (L.J. Toedter, J.N. Lasker, & J.M. Alhadeff), 1988, the Maternal Postnatal Attachment Scale (J.T. Condon & C.J. Corkindale, 1998), and the Neonatal Perception Inventory II (E. Broussard, 1979). Results showed a significant negative relationship between grief intensity and the attachment level, r = −.37, p = .000, and a significant positive relationship between the attachment level and neonatal perception, r = .28, p = .000. Mothers’ grief intensity was significantly affected by their demographic characteristics; however, there was no significant relationship between grief intensity and neonatal perception, r = .23, p = .23. Perinatal grief was negatively related to maternal attachment to the subsequent child. Nurses should address bereaved mothers and their children who might be at risk for developing attachment disturbances to facilitate positive adaptation to the subsequent pregnancy and parenthood.
PARALLEL MODELS OF ASSESSMENT: INFANT MENTAL HEALTH AND THERAPEUTIC ASSESSMENT MODELS INTERSECT THROUGH EARLY CHILDHOOD CASE STUDIES
Authors: Gart Natalie , Zamora Irina , Williams Marian E. 
Published: June 2016

ABSTRACTTherapeutic Assessment (TA; S.E. Finn & M.E. Tonsager, 1997; J.D. Smith, 2010) is a collaborative, semistructured model that encourages self‐discovery and meaning‐making through the use of assessment as an intervention approach. This model shares core strategies with infant mental health assessment, including close collaboration with parents and caregivers, active participation of the family, a focus on developing new family stories and increasing parents’ understanding of their child, and reducing isolation and increasing hope through the assessment process. The intersection of these two theoretical approaches is explored, using case studies of three infants/young children and their families to illustrate the application of TA to infant mental health. The case of an 18‐month‐old girl whose parents fear that she has bipolar disorder illustrates the core principles of the TA model, highlighting the use of assessment intervention sessions and the clinical approach to preparing assessment feedback. The second case follows an infant with a rare genetic syndrome from ages 2 to 24 months, focusing on the assessor–parent relationship and the importance of a developmental perspective. Finally, assessment of a 3‐year‐old boy illustrates the development and use of a fable as a tool to provide feedback to a young child about assessment findings and recommendations.
Timing of mesenchymal stem cell delivery impacts the fate and therapeutic potential in intervertebral disc repair
Authors: Maidhof Robert , Rafiuddin Asfi , Chowdhury Farzana , Jacobsen Timothy , Chahine Nadeen O. 
Published: June 2016

ABSTRACTCell‐based therapies offer a promising approach to treat intervertebral disc (IVD) degeneration. The impact of the injury microenvironment on treatment efficacy has not been established. This study used a rat disc stab injury model with administration of mesenchymal stromal cells (MSCs) at 3, 14, or 30 days post injury (DPI) to evaluate the impact of interventional timing on IVD biochemistry and biomechanics. We also evaluated cellular localization within the disc with near infrared imaging to track the time and spatial profile of cellular migration after in vivo delivery. Results showed that upon injection into a healthy disc, MSCs began to gradually migrate outwards over the course of 14 days, as indicated by decreased signal intensity from the disc space and increased signal within the adjacent vertebrae. Cells administered 14 or 30 DPI also tended to migrate out 14 days after injection but cells injected 3 DPI were retained at a significantly higher amount versus the other groups (p < 0.05). Correspondingly the 3 DPI group, but not 14 or 30 DPI groups, had a higher GAG content in the MSC injected discs (p = 0.06). Enrichment of MSCs and increased GAG content in 3 DPI group did not lead to increased compressive biomechanical properties. Findings suggest that cell therapies administered at an early stage of injury/disease progression may have greater chances of mitigating matrix loss, possibly through promotion of MSC activity by the inflammatory microenvironment associated with injury. Future studies will evaluate the mode and driving factors that regulate cellular migration out of the disc. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:32–40, 2017.
A population‐based comparison of 30‐day readmission after surgery for colon and rectal cancer: How are they different?
Authors: Doumouras Aristithes G. , Tsao Miriam W. , Saleh Fady , Hong Dennis 
Published: June 2016

BackgroundAn implicit assumption in the analysis of colorectal readmission is that colon and rectal cancer patients are similar enough to analyze together. However, no studies have examined this assumption and whether substantial differences exist between colon and rectal cancer patients.MethodsThis was a retrospective analysis of the differences in predictors, diagnoses, and costs of readmission between colon and rectal cancer cohorts for 30‐day readmission. This study included all patients aged >18 who received an elective colectomy or low anterior resection for colorectal cancer from April 2008 until March 2012 in the province of Ontario.ResultsOverall, 13,571 patients were identified and the readmission rates significantly differed between rectal and colon cancer patients (7.1% colon and 10.7% rectal P = 0.001). Diabetes, age, and discharge to long term care were significantly different among colon and rectal patients in the prediction of readmission. Readmission for renal and stoma causes was more prominent in the rectal cohort. The adjusted cost difference for readmission did not significantly differ between rectal and colon cancer $178 ($1,924–1,568 P = 0.84)ConclusionSeveral important differences in predictors and diagnoses exist between the two cohorts. Conversely, the costs associated with readmission were homogenous between rectal and colon cancer patients. J. Surg. Oncol. 2016;114:354–360. © 2016 Wiley Periodicals, Inc.
On the Termination Mechanism in the Radical Polymerization of Acrylates
Authors: Ballard Nicholas , Hamzehlou Shaghayegh , Ruipérez Fernando , Asua José M. 
Published: June 2016

In a recent publication, Nakamura and co‐workers studied the termination mechanism in the radical polymerization of acrylates. Contrary to conventional thinking, their conclusion is that termination is overwhelmingly by disproportionation. This finding impacts on a large body of the previous work in the polymerization of acrylic monomers which this work seeks to address. Analysis of the molecular weight distribution of acrylic polymers obtained under different polymerization conditions shows that termination by combination is the more probable mechanism for mutual termination of secondary radicals. It is proposed that in the experiments conducted by Nakamura and co‐workers, backbiting plays a key role and their experimental data are reinterpreted, showing that they are more revealing with respect to the mode of termination of the midchain radical produced by backbiting, than to bimolecular termination of secondary radicals.
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The Effects of Acupressure Training on Sleep Quality and Cognitive Function of Older Adults: A 1‐Year Randomized Controlled Trial
Authors: Zeng Hui , Liu Mengjiao , Wang Ping , Kang Jiaxun , Lu Fenghua , Pan Lu 
Published: June 2016

AbstractWe explored the effects of acupressure training on older adults’ sleep quality and cognitive function. Ninety older adults with impaired sleep quality were selected from screened volunteers and randomly divided into equal control and experimental groups; 82 completed the 1‐year follow‐up. Participants in the control group were given instructions on sleep health, while those in the experimental group received sleep health instructions plus individual and small group acupressure training sessions and support to practice the intervention on their own each day. All participants were assessed by trained assistants blind to study group allocation using Chinese versions of the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale, the Mini‐Mental State Examination, and four subscales from the revised Chinese version of the Wechsler Memory Scale, at baseline and at 3, 6, and 12 months. Repeated measures analysis of variance showed that acupressure training improved older adults’ sleep quality and cognitive function, but the mediating effect of sleep on the relationship between acupressure training and cognitive function was not supported. Given the ease, simplicity, and safety of acupressure training observed with community‐dwelling older adults in China, attempts should be made to replicate these preliminary positive findings with larger samples. © 2016 Wiley Periodicals, Inc.
Penultimate effects in the copolymerization of maleic anhydride with electron‐rich styrene derivatives
Authors: ten Brummelhuis Niels , Stutz Marvin Björn 
Published: June 2016

ABSTRACTThe (controlled) free‐radical copolymerization of maleic anhydride and styrene or derivatives thereof is often thought to provide nearly perfect alternating copolymers. Here, the RAFT copolymerization of electron‐rich styrene derivatives with maleic anhydride is reported. This copolymerization shows distinct penultimate effects, resulting in polymers with increased incorporation of styrene monomers, that is, where a tendency toward periodic (S‐S‐MA) copolymers exists. This work could be a first step towards periodic copolymers based on maleic anhydride and styrene derivatives. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 2932–2939
Small‐angle X‐ray scattering as a useful supplementary technique to determine molecular masses of polyelectrolytes in solution
Authors: Plazzotta Beatrice , Diget Jakob Stensgaard , Zhu Kaizheng , Nyström Bo , Pedersen Jan Skov 
Published: June 2016

ABSTRACTDetermination of molecular masses of charged polymers is often nontrivial and most methods have their drawbacks. For polyelectrolytes, a new possibility for the determination of number‐average molecular masses is represented by small‐angle X‐ray scattering (SAXS) which allows fast determinations with a 10% accuracy. This is done by relating the mass to the position of a characteristic peak feature which arises in SAXS due to the local ordering caused by charge‐repulsions between polyelectrolytes. Advantages of the technique are the simplicity of data analysis, the independency from polymer architecture, and the low sample and time consumption. The method was tested on polyelectrolytes of various structures and chemical compositions, and the results were compared with those obtained from more conventional techniques, such as asymmetric flow field‐flow fractionation, gel permeation chromatography, and classical SAXS data analysis, showing that the accuracy of the suggested method is similar to that of the other techniques. © 2016 The Authors. Journal of Polymer Science Part B: Polymer Physics Published by Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 1913–1917
Ionic Liquid and Biofuel Blend: A Low–cost and High Performance Hypergolic Fuel for Propulsion Application
Authors: Bhosale Mr. Vikas K. , Kulkarni Suresh G. , Kulkarni Prashant S. 
Published: June 2016

AbstractHypergolic fuel has unique importance in missiles and satellite launch vehicles. Hydrazine and its derivatives (Monomethyl hydrazine, MMH and Unsymmetrical Dimethyl Hydrazine, UDMH) are the continuous choices of fuel in bipropellant though it is carcinogenic and toxic. Development of new, green and cost‐effective fuel blends based on trust‐worthy, ionic liquid and biofuel in different volume proportion have been reported. The blends exhibit reasonably good stability (chemical and thermal), low viscosity (η < 15 mPa⋅s), high density (ρ > 1 g/cm3), low ignition delay and high performance in comparison with UDMH ‐ a proven liquid fuel presently being used as promising fuels for liquid rocket application. The reported blends appear to be a technologically promising, eco‐friendly and affordable fuel blend to replace currently used liquid toxic fuels.
Functionalization of Quinolines through Copper‐Catalyzed Regioselective Halogenation Reaction
Authors: Sahoo Harekrishna , Ramakrishna Isai , Baidya Mahiuddin 
Published: June 2016

AbstractA copper‐catalyzed chelation‐controlled remote C–H halogenation of quinolines is developed. The reaction is scalable and proceeded with excellent C5‐regioselectivity offering halogen‐substituted 8‐aminoquinolines in very high yields (up to 97 %). The products were further utilized for various cross‐coupling reactions en route to highly C5‐functinonalized quinolines. As an application, synthesis of a bioactive compound having tumor‐suppressor activity was accomplished.
Investigation of Size Sensitivity in the Hydrogen Production from Formic Acid over Carbon‐Supported Pd Nanoparticles
Authors: Navlani‐García Miriam , Mori Kohsuke , Nozaki Ai , Kuwahara Yasutaka , Yamashita Hiromi 
Published: June 2016

AbstractThe size effect in the hydrogen production from formic acid decomposition has been investigated using a series of carbon‐supported Pd NPs with different particle sizes ranging from 2.7 to 5.5 nm. A volcano type relationship between catalytic activity and NPs size was obtained. This result suggests that there is an optimum relative proportion of low‐ and high‐coordination surface atoms within a regular arrangement of the Pd NPs, which was achieved at 3.9 nm in diameter under the present experimental conditions. By performing calculations on the palladium crystallites, decomposition of formic acid is considered as a structure‐sensitive reaction, and high‐coordination sites principally act as catalytically active species in this size range. Kinetic isotope effect using HCOOD and DCOOH was well corresponded to the catalytic tendency. A kH/kD value obtained with Pd/C with optimal size was smallest among investigated, indicating the positive promoting effect in the rate‐determining C−H bond dissociation step from the Pd‐formate intermediate.
Extended π‐Conjugated Pyrene Derivatives: Structural, Photophysical and Electrochemical Properties
Authors: Feng Xing , Seto Nobuyuki , Wang Chuan‐Zeng , Matsumoto Taisuke , Tanaka Junji , Wei Xian‐Fu , Elsegood Mark R. J. , Horsburgh Lynne , Redshaw Carl , Yamato Takehiko 
Published: June 2016

AbstractThis article presents a set of extended π‐conjugated pyrene derivatives, namely 1,3‐di(arylethynyl)‐7‐tert‐butylpyrenes, which were synthesized by a Pd‐catalyzed Sonogashira coupling reaction of 1,3‐dibromo‐7‐tert‐butylpyrenes with the corresponding arylethynyl group in good yields. Despite the presence of thetert‐butyl group located at the 7‐position of pyrene, X‐ray crystallographic analyses show that the planarity of theY‐shaped molecules still exhibits strong face‐to‐face π‐π stacking in the solid state; all of the compounds exhibit blue or green emission with high quantum yields (QYs) in dichloromethane. DFT calculations and electrochemistry revealed that this category of compound possesses hole‐transporting characteristics. In addition, with strong electron‐donating (‐N(CH3)2) or electron‐withdrawing (‐CHO) groups in2 dor2 f, these molecules displayed efficient intramolecular charge‐transfer (ICT) emissions with solvatochromic shifts from blue to yellow (green) on increasing the solvent polarity. Furthermore, the compounds2 dand2 fpossess strong CT characteristics.
Improving scientific application execution on android mobile devices via code refactorings
Authors: Rodriguez Ana , Mateos Cristian , Zunino Alejandro 
Published: June 2016

SummaryThe increasing number of mobile devices with ever‐growing capabilities makes them useful for running scientific applications. However, these applications have high computational demands, whereas mobile devices have limited capabilities when compared with non‐mobile devices. More importantly, mobile devices rely on batteries for their power supply. We initially measure the battery consumption of different versions of known micro‐benchmarks representing common programming primitives found in scientific applications. Then, we analyze the performance of such micro‐benchmarks in CPU‐intensive mobile applications. We apply good programming practices and code refactorings to reduce battery consumption of scientific mobile applications. Our results show the reduction in energy usage from applying these refactorings to three scientific applications, and we consequently propose guidelines for high‐performance computing applications. Our focus is on Android, the dominant mobile operating system. As a long‐term contribution, our results represent one more step in the progress towards hybrid distributed infrastructures comprising fixed and mobile nodes, that is, the so‐called mobile grids. Copyright © 2016 John Wiley & Sons, Ltd.
HucMSC Exosome-Delivered 14-3-3ζ Orchestrates Self-Control of the Wnt Response via Modulation of YAP During Cutaneous Regeneration
Authors: Zhang Bin , Shi Yinghong , Gong Aihua , Pan Zhaoji , Shi Hui , Yang Huan , Fu Hailong , Yan Yongmin , Zhang Xu , Wang Mei , Zhu Wei , Qian Hui , Xu Wenrong 
Published: June 2016

Abstract
Numerous studies showed that mesenchymal stem cells derived exosome (MSC-Ex) markedly enhanced tissue regeneration, however, the issue of whether MSC-Ex could control stem cells expansion after a regenerative response to prevent tissue from overcrowding and dysplasia remains to be established. Herein, we found that human umbilical cord MSC (hucMSC)-exosomal14-3-3ζ mediated the binding of YAP and p-LATS by forming a complex to promote the phosphorylation of YAP, which orchestrate exosomal Wnt4 signal in cutaneous regeneration. First, we assessed deep second-degree burn rats treated with hucMSC-Ex and discovered that hucMSC-Ex promoting self-regulation of Wnt/β-catenin signaling at the remodeling phase of cutaneous regeneration. HucMSC-Ex restricted excessive skin cell expansion and collagen deposition at 4 weeks. Under high cell density conditions, hucMSC-Ex inhibited Wnt/β-catenin signaling through induction of YAP phosphorylation. Second, hucMSC-Ex proteomic analysis revealed that 14-3-3 proteins could be transported by exosome. Using gain- and loss-of-function studies, our results showed that hucMSC-exosomal 14-3-3ζ controlled YAP activities and phosphorylation at Ser127 site, and were required for the binding of YAP and p-LATS. Further studies revealed that 14-3-3ζ recruited YAP and p-LATS to form a complex under high cells density status and 14-3-3ζ other than YAP or p-LATS was the key regulatory molecule of this complex. These findings collectively indicate that hucMSC-Ex functions not only as an “accelerator” of the Wnt/β-catenin signal to repair damaged skin tissue but also as a “brake” of the signal by modulating YAP to orchestrate controlled cutaneous regeneration.
Glycoengineering of E-Selectin Ligands by Intracellular versus Extracellular Fucosylation Differentially Affects Osteotropism of Human Mesenchymal Stem Cells
Authors: Dykstra Brad , Lee Jungmin , Mortensen Luke J. , Yu Haixiao , Wu Zhengliang L. , Lin Charles P. , Rossi Derrick J. , Sackstein Robert 
Published: June 2016

Abstract
Human mesenchymal stem cells (MSCs) hold great promise in cellular therapeutics for skeletal diseases but lack expression of E-selectin ligands that direct homing of blood-borne cells to bone marrow. Previously, we described a method to engineer E-selectin ligands on the MSC surface by exofucosylating cells with fucosyltransferase VI (FTVI) and its donor sugar, GDP-Fucose, enforcing transient surface expression of the potent E-selectin ligand HCELL with resultant enhanced osteotropism of intravenously administered cells. Here, we sought to determine whether E-selectin ligands created via FTVI-exofucosylation are distinct in identity and function to those created by FTVI expressed intracellularly. To this end, we introduced synthetic modified mRNA encoding FTVI (FUT6-modRNA) into human MSCs. FTVI-exofucosylation (i.e., extracellular fucosylation) and FUT6-modRNA transfection (i.e., intracellular fucosylation) produced similar peak increases in cell surface E-selectin ligand levels, and shear-based functional assays showed comparable increases in tethering/rolling on human endothelial cells expressing E-selectin. However, biochemical analyses revealed that intracellular fucosylation induced expression of both intracellular and cell surface E-selectin ligands and also induced a more sustained expression of E-selectin ligands compared to extracellular fucosylation. Notably, live imaging studies to assess homing of human MSC to mouse calvarium revealed more osteotropism following intravenous administration of intracellularly-fucosylated cells compared to extracellularly-fucosylated cells. This study represents the first direct analysis of E-selectin ligand expression programmed on human MSCs by FTVI-mediated intracellular versus extracellular fucosylation. The observed differential biologic effects of FTVI activity in these two contexts may yield new strategies for improving the efficacy of human MSCs in clinical applications.