bluuebunny/crossref_metadata_2025_split huggingface dataset:
Materialsparende Betondecke aus 3D‐gedruckten Verriegelungsblöcken
Authors: Neef Tobias , Goertzen Tom , Niemeyer Alice , Mechtcherine Viktor 
Published: October 2024

AbstractEin neues modulares Konstruktionsprinzip hat das Potenzial, die Betonbauweise zu revolutionieren: topologische Verriegelung von Bausteinen. Durch die innovative Anordnung dieser Verriegelungsblöcke wird eine kinematische Beanspruchung einzelner Bausteine durch die gesamte Baugruppe effektiv unterbunden, indem die Blöcke sich gegenseitig immobilisieren. Diese Studie untersucht die Synergie zwischen topologisch ineinandergreifenden Baugruppen (TIA = englisch „topological interlocking assemblies“) und 3D‐Betondruck und führt eine umfassende Analyse der Herstellungsverfahren und der strukturellen Leistungsfähigkeit durch. Die ohne Bindemittel ineinandergreifenden Verriegelungsblöcke bieten herausragende Perspektiven für nachhaltiges Bauen. In der Untersuchung wird eine Methode zur Optimierung der Blockgeometrien für den 3D‐Druck vorgestellt, um die Integrität der Verriegelung sicherzustellen. Drei spezifische Blockgeometrien werden für den 3D‐Betondruck entwickelt und getestet. Verschiedene Methoden werden angewendet, um Verriegelungsblöcke herzustellen. Eine Geometrie wird ausgewählt und sowohl im kleinen als auch im großen Maßstab erprobt. Es folgen experimentelle Prüfungen, einschließlich präziser 3D‐Fotogrammetriemessungen, zur Bewertung des strukturellen Verhaltens dieser Plattensysteme. Die Ergebnisse demonstrieren eindrucksvoll die Machbarkeit und das enorme Potenzial der Integration von topologischer Verriegelung und 3D‐Betondruck für zukunftsfähige Bauanwendungen.
A plant mutant screen CURE integrated with core biology concepts showed effectiveness in course design and students' perceived learning gains
Authors: Liu Jinjie , Benning Christoph 
Published: October 2024

AbstractCourse‐based undergraduate research experiences (CUREs) provide students with valuable opportunities to engage in research in a classroom setting, expanding access to research opportunities for undergraduates, fostering inclusive research and learning environments, and bridging the gap between the research and education communities. While scientific practices, integral to the scientific discovery process, have been widely implemented in CUREs, there have been relatively few reports emphasizing the incorporation of core biology concepts into CURE curricula. In this study, we present a CURE that integrates core biology concepts, including genetic information flow, phenotype–genotype relationships, mutations and mutants, and structure–function relationships, within the context of mutant screening and gene loci identification. The design of this laboratory course aligns with key CURE criteria, as demonstrated by data collected through the laboratory course assessment survey (LCAS). The survey of undergraduate research experiences (SURE) demonstrates students' learning gains in both course‐directed skills and transferrable skills following their participation in the CURE. Additionally, concept survey data reflect students' self‐perceived understanding of the aforementioned core biological concepts. Given that genetic mutant screens are central to the study of gene function in biology, we anticipate that this CURE holds potential value for educators and researchers who are interested in designing and implementing a mutant screen CURE in their classrooms. This can be accomplished through independent research or by establishing partnerships between different units or institutions.
LC enantioseparation of active pharmaceutical ingredients using rationally synthesized CDRs and chiral molecules with high molar absorptivity
Authors: Sethi Sonika , Bhushan Ravi 
Published: October 2024

AbstractThe synthesis of optically active compounds requires determination of ee, er, and enantiomeric purity. The aim of the present paper is to review the synthesis of several chiral derivatizing reagents (CDRs) in a rational manner, which were successful for the separation and isolation of enantiomers of a variety of active pharmaceutical ingredients and other important and useful racemates. Besides, the application of (i) certain enantiomerically pure amines, either directly or by incorporating each of them as chiral auxiliary in difluorodinitrobenzene or cyanuric chloride moieties to construct the CDR, (ii) (S)‐ketoprofen and (S)‐levofloxacin as chiral platforms, and (iii) a few isothiocyanates, have been suitably included. Attention is drawn to the use of water micellar mobile phase as the “green” RP‐HPLC method and the use of simple achiral derivatization with ninhydrin, particularly. Synthesis of CDRs and their application for enantioseparation of racemates and detagging of certain chromophoric reagent components for obtaining native enantiomers are other interesting features included herein. The methods can be easily used to determine and control enantiomeric purity with advantages over a variety of commercial chiral phases. This comprehensive review not only highlights innovative methodologies for enantioseparation but also underscores their practical applications in controlling and ensuring the enantiomeric purity of pharmaceutical compounds.
Association Between Cancer Screening Patterns and Carer Literacy in Individuals With Cognitive Decline: An Observational Study
Authors: Kuroda Yujiro , Goto Aya , Uchida Kazuaki , Sugimoto Taiki , Fujita Kosuke , Yokoyama Yoko , Nakagawa Takeshi , Saito Tami , Noguchi Taiji , Komatsu Ayane , Arai Hidenori , Sakurai Takashi 
Published: October 2024

ABSTRACTObjectiveThe incidence rates of dementia, mild cognitive impairment, and cancer increase with age, posing challenges to affected individuals and their families. However, there are currently no clear cancer screening guidelines for individuals with cognitive impairment. This study analyzed the impact of carer health literacy on screening behaviors in this population.MethodsWe conducted a postal follow‐up survey, associated with the National Center for Geriatrics and Gerontology—Life STORIES of People with Dementia, that targeted primary carers to assess their reports regarding patient attendance at regular cancer screenings recommended by the Japanese Ministry of Health, Labor and Welfare, over the preceding 2 years. Screening rates were compared between the memory clinic cohort and the national average, and the influence of carer health literacy level on screening was analyzed.ResultsAmong the 826 total individuals analyzed, the memory clinic cohort exhibited lower breast cancer screening rates, at 11% among female patients aged 65–74 years versus the national average of 32%. Higher health literacy among carers was significantly associated with increased screening. For female patients, carers with high levels of communicative health literacy were more likely to ensure that patients attended screenings for gastric (adjusted odds ratio [AOR], 1.77; 95% confidence interval [CI], 1.03–3.04), colorectal (AOR, 1.70, 95% CI 1.08–2.70), and breast cancers (AOR, 3.08; 95% CI, 1.40–6.76). Among the male patients, high communicative health literacy was associated with increased lung cancer screening attendance (AOR, 1.82; 95% CI, 1.11–2.99).ConclusionsOur research highlights a notable gap in cancer screening attendance between individuals with cognitive impairment and the general population, potentially arising from the intricate nature of screening procedures and the extensive burden on carers. More informed decisions and increased screening rates can be achieved through patient‐centric communication strategies that accommodate the cognitive abilities of patients, ensuring the comprehensibility and accessibility of health‐related information.
Phytochemical Riches, Bioactivities, and Clinical Potential of Prinsepia utilis Royle: A Comprehensive Review
Authors: Prakash Suraj , Radha  , Puri Sunil , Dhumal Sangram , Kumar Sunil , Senapathy Marisennayya , Kumar Manoj 
Published: October 2024

AbstractPrinsepia utilis Royle, known for its diverse applications in traditional medicine (Chinese and Indian folk medicines), has garnered substantial attention within the field of phytochemistry and bioactivity exploration. P. utilis is a deciduous shrub from the family Rosaceae which is predominantly distributed within the Himalayan Mountain range at altitudes ranging from 1000 to 3000 meters above sea level. This paper is mainly focused on present state of knowledge about P. utilis, focusing on compiling a comprehensive and current database encompassing its phytochemical composition and associated bioactivities. Various phytochemical investigations of P. utilis have yielded a rich repository of secondary metabolites, including alkaloids, flavonoids, phenolics, and terpenoids. Various studies have reported the bioactivities attributed to P. utilis extracts, fractions, or isolated compounds showing the antioxidant, anti‐inflammatory, antimicrobial, enzymatic inhibitory (α‐glucosidase and lipase), immunosuppressive, and cytotoxic. In vivo investigations have demonstrated anti‐inflammatory, anti‐benign prostatic hyperplasia effects, osteoprotective, and hypoglycemic activity aligning with traditional claims. For treatment of atrophic dermatitis and acne vulgaris, formulations containing P. utilis extract have been developed with proven effectiveness. Furthermore, the exploration of P. utilis phytochemistry and bioactivities highlights its promising ability as source of novel therapeutic agents and functional additives. However, further studies are required which integrate pharmacological evaluations, clinical trials, and sustainable cultivation practices to unlock its pharmaceutical and industrial applications.
Benzylpiperazinyl Derivatives of Alepterolic Acid: Synthesis and Cytotoxic Evaluation
Authors: Wang Xin , Qin Li , Ma Lian , Dai Xiling , Huang Guozheng , Cao Jianguo 
Published: October 2024

AbstractNatural products play a significant role in the development of modern drugs. Alepterolic acid, a labdane‐type diterpenoid firstly isolated from Aleuritopteris argentea (Gmél.) Fée, has been identified as a valuable template for the synthesis of potent anticancer agents by structural modification. In this study, a series of new derivatives was obtained by coupling alepterolic acid with benzylpiperazines. It was found that (3,4‐dichlorobenzyl)piperazinyl alepterolic acid (compound 6p) displayed the highest level of toxicity against MCF‐7 cell line, with an IC50 value of 8.31±0.67 μM. Further investigations demonstrated that compound 6p induced morphological changes in MCF‐7 cells, inhibited proliferation in a time‐ and dose‐dependent manner. Furthermore, western blot analysis revealed that compound 6p induced a significant increase in cleaved caspase‐9, cleaved caspase‐3, cleaved poly (ADP‐ribose) polymerase (PARP) and Bax/Bcl‐2 ratio in MCF‐7 cells. All of these results confirmed that compound 6p induced endogenous apoptosis in MCF‐7 cells. Conclusively, the findings suggest that the incorporation of benzylpiperazine to alepterolic acid represents a promising approach for the discovery of new drug candidates.
Anti‐inflammatory Fatty Acid Derivatives From Mangrove‐derived Actinomycetes Streptomyces sp.
Authors: Ge Cheng , Xu Han , Zhang Xue‐Ying , Wu Gui‐Xin , Yang Min , Gu Yu‐Qin , Li Jian Lin 
Published: October 2024

AbstractMangrove‐derived actinomycetes are prolific chemical sources of complex and novel natural products, providing an excellent chance for new drug discovery. The chemical investigation of the mangrove‐derived Streptomyces sundarbansensis 06037, led to the discovery of two previously undescribed enone fatty acids (1–2), one new phenylpropionate derivate (3), along with the isolation of the ten known components (4–13). Those chemical structures of isolates were elucidated on the basis of the analysis of diverse spectroscopic data. Initial anti‐inflammatory tests of 1–3 in lipopolysaccharide (LPS)‐activated RAW 264.7 murine macrophage cells revealed that compound 1 possess significant inhibitory effect on the production of Nitro oxidase (NO), with the IC50 value around 15.33±1.32 μM, together with the suppression of NF‐κB phosphorylation and reducing the release of oxygen species (ROS) in RAW 264.7 macrophages, those results indicated that compound 1 may exert its anti‐inflammatory activity through a reduction in ROS level and the suppression of NF‐κB activation pathway.
Wuzi Yanzong Decoction Ameliorates Oligoasthenozoospermia by Up‐Regulating Methyltransferase and Increasing Spata, Bcl, and Pik3 Series Genes Methylation Level
Authors: Lin Qiyan , Ge Xiyu , Li Xia , Gu Fangli , Gao Leilei , Su Ting , Chen Yanjun , Yang Li , Liu Dong , Han Bangxing , Chen Cunwu 
Published: October 2024

AbstractWuzi Yanzong decoction (WZYZD) belongs to the traditional formula for treating male infertility caused by oligoasthenozoospermia (OLI). This research aims to elucidate the therapeutic substance basis and potential pharmacological mechanisms of WZYZD in treating OLI. A total of 52 chemical ingredients were identified from WZYZD. HE and TUNEL staining demonstrated that WZYZD can markedly alleviate OLI. Immunofluorescence analysis showed that WZYZD can significantly increase the expression levels of DNMT3 A, PIWIL1, SETDB1, and PRMT5. Methyl capture sequencing proved that WZYZD can markedly upregulate the methylated level of Spata, Bcl, and Pik3 series genes. Network pharmacology analysis proved that WZYZD can ameliorate OLI through BCL‐2 and PI3 K‐AKT signaling pathways. The immunofluorescence assay of BCL‐2 and SPATA18 proved the aforementioned results. The potential mechanism of WZYZD in treating OLI mainly involved recruiting methyltransferase DNMT3 A, PIWIL1, PRMT5, and SETDB1 and increasing the methylation degree of Spata, Bcl, and Pik3 series genes.
Rotational, orbital atherectomy and intravascular lithotripsy for coronary calcified nodules: insights from optical coherence tomography
Authors: Yasumura Keisuke , Koshy Anoop N. , Vinayak Manish , Vengrenyuk Yuliya , Minatoguchi Shingo , Krishnamoorthy Parasuram , Hooda Amit , Sharma Raman , Kapur Vishal , Sweeny Joseph , Sharma Samin K. , Kini Annapoorna S. 
Published: October 2024

AbstractBackgroundThe optimal treatment strategy for coronary calcified nodules (CN) remains uncertain. We aimed to evaluate the efficacy and safety of different calcium modification strategies, including rotational atherectomy (RA), orbital atherectomy (OA), and intravascular lithotripsy (IVL) for managing CN with optical coherence tomography (OCT) guidance.MethodsConsecutive patients undergoing OCT‐guided percutaneous coronary intervention (PCI) for severely calcified lesions using RA, OA, or IVL between January 2017 and December 2022 were included. Primary endpoint was minimum stent area (MSA) post‐PCI. Secondary endpoints included MSA at CN site and 1‐year target vessel failure (TVF), defined as a composite of cardiac death, target‐vessel myocardial infarction, or target vessel revascularization.ResultsAmong 154 patients and 158 lesions, CN was identified in 54 lesions (34.2%) and managed with RA (39%, n = 21), OA (33%, n = 18), or IVL (28%, n = 15). The IVL group exhibited a larger minimal lumen diameter, maximum calcium arc, and maximum calcium thickness. Post‐PCI OCT demonstrated comparable MSA (RA: 6.23 ± 0.34 mm², OA: 5.75 ± 0.39 mm², IVL: 6.24 ± 0.46 mm²; p = 0.62) and MSA at CN site (7.17 ± 0.43 mm², 6.46 ± 0.49 mm², 7.86 ± 0.56 mm², respectively; p = 0.55) after adjusting for morphologic factors. The incidence of TVF at 1 year was similar among the group (RA: 19.0%, OA: 22.2%, IVL: 13.3%, p = 0.81).ConclusionsIn patients undergoing PCI for CN, similar procedural and clinical outcomes can be achieved using RA, OA, or IVL. These findings warrant further investigation in larger, prospective trials.
Hollow Superhelices Based on Chiral Europium Coordination Polymers
Authors: Zhai Zhi‐Min , Hou Ting , Xu Yan , Teng Qian , Bao Song‐Song , Zheng Li‐Min 
Published: October 2024

AbstractThe construction of helical nanotubes based on chiral coordination polymers (CPs) is an intriguing but challenging task, which is important for the development of functional materials that combine macroscopic chirality with tube‐related properties. Here, we selected a chiral europium phosphonate system, e. g., Eu(NO3)3/R‐,S‐pempH2, and carried out a systematic work. By controlling the hydrothermal reaction conditions such as the pH value of the reaction mixture, the molar ratio and concentration of the reactants, we obtained block‐like crystals of R/S‐1 b, rod‐like crystals of R/S‐3 r, hollow superhelices of R/S‐2 hh, and solid superhelices of R/S‐4 sh. In the latter two cases, the chirality has been successfully transferred and amplificated from the molecular level to the macroscopic level. Interestingly, compounds R/S‐2 hh and R/S‐4 sh have the same chemical composition of Eu(R/S‐pempH)3⋅2H2O and show identical PXRD patterns, thus can be considered as the same material except for different morphologies. We further investigated their circularly polarized luminescence (CPL) properties and found that the hollow superhelix of R/S‐2 hh had a larger dissymmetry factor than the solid superhelix of R/S‐4 sh. This study not only provides the first example of hollow superhelices of chiral CPs, but also offers the possibility of modulating the chiroptical properties of CPs through morphological control.
Application of Spectrogel clay as a support for immobilization of lipase from Burkholderia cepacia
Authors: Molinari Deise , da Silva Edson Antonio , Aranha Ana Caroline Raimundini , Paschoal Sirlei Marques , Martin Lucas Serra , Arroyo Pedro Augusto , Canevesi Rafael Luan Sehn , Zanin Gisella Maria 
Published: October 2024

AbstractThe interest in maximizing the production of ethyl esters in a sustainable way and with lower energy costs has increased the use of immobilized enzymes as catalysts. This study aimed to apply the commercial clay Spectrogel® as a support for the immobilization of lipase from Burkholderia cepacia by adsorption and covalent bonding methods. The immobilizations were carried out using a 23 factorial design to study the effects of the activity offered (U g−1), pH, and the molar concentration of the enzyme solution buffer (mol L−1) on the enzyme activity obtained (U g−1). From the statistical analysis of the results, the best conditions for immobilization were pH 7.0 and 0.1 mol L−1 for both tested immobilization methods, with the best offered activity being 5709 and 7600 U g−1. The activities obtained were 1219.81 ± 7.51 and 1274.89 ± 14.99 U g−1 for adsorption and covalent bonding, respectively. The biocatalysts exhibited protein leaching of 33.55 ± 1.08% and 19.44 ± 2.43% when immobilized by adsorption and covalent bonding, respectively. The optimal activity temperature and thermal stability were obtained at 40°C. Additionally, the immobilization of lipase in Spectrogel® by both methods was efficient, showing higher thermal stability than the free enzyme. Thus, this work contributed scientifically to the development of a new and economical biocatalyst for ethyl ester production.
Cerebellar Molecular Signatures in Non‐Human Primates
Authors: Yamamoto Tatsuya , Yoshida Yuko , Ose Takayuki , Murata Yumi , Hayashi Takuya , Higo Noriyuki 
Published: October 2024

ABSTRACTCerebellar molecular signatures in primates remain largely unexplored. Here, we investigated the immunoreactivity of neuroplasticity‐related molecular markers, including aldolase C (Aldoc), phospholipase C beta 3 (PLCB3), and phospholipase C beta 4 (PLCB4) in the cerebellar cortex and associated nuclei of rhesus macaque monkeys (Macaca mulatta). Our main findings are as follows: First, the cerebellar vermis in macaques exhibited striped compartmentalization for all markers, with the striped expression boundary of PLCB3 being less distinct than those of Aldoc and PLCB4. Second, the striped pattern was less pronounced in the cerebellar hemisphere compared to the vermis, with signals in the hemisphere being predominantly intense throughout. Third, distinct zonal patterns and elevated signals for Aldoc and PLCB3 were observed in the cerebellar deep nuclei. Specifically, the fastigial nucleus displayed intense Aldoc signals in both caudal and rostral regions, while the dentate nucleus displayed strong Aldoc signals in both ventral and dorsal regions. Compared to previous rodent studies, the macaque cerebellum demonstrated a higher proportion of intense signal areas and distinct compartmentalization patterns in both cortical and deep nuclei. These findings offer crucial insights into the unique molecular organization of the primate cerebellum, enhancing our understanding of the advanced neuroplasticity, cognitive, and motor capabilities in primates.
A Multiscale Mathematical Model for the Fetal Blood Circulation of the Second Half of Pregnancy
Authors: van Willigen Bettine G. , van der Hout‐van der Jagt M. Beatrijs , Bovendeerd Peter H. M. , Huberts Wouter , van de Vosse Frans N. 
Published: October 2024

ABSTRACTDoppler ultrasound is a commonly used method to assess hemodynamics of the fetal cardiovascular system and to monitor the well‐being of the fetus. Indices based on the velocity profile are often used for diagnosis. However, precisely linking these indices to specific underlying physiology factors is challenging. Several influences, including wave reflections, fetal growth, vessel stiffness, and resistance distal to the vessel, contribute to these indices. Understanding these data is essential for making informed clinical decisions. Mathematical models can be used to investigate the relation between velocity profiles and physiological properties. This study presents a mathematical model designed to simulate velocity wave propagation throughout the fetal cardiovascular system, facilitating the assessment of factors influencing velocity‐based indices. The model combines a one‐fiber model of the heart with a 1D wave propagation model describing the larger vessels of the circulatory system and a lumped parameter model for the microcirculation. Fetal growth from 20 to 40 weeks of gestational age is incorporated by adjusting cardiac and circulatory parameter settings according to scaling laws. The model's results, including cardiac function, cardiac output distribution, and volume distribution, show a good agreement with literature studies for a growing healthy fetus from 20 to 40 weeks. In addition, Doppler indices are simulated in various vessels and agree with literature as well. In conclusion, this study introduces a novel closed‐loop 0D‐1D mathematical model that has been verified against literature studies. This model offers a valuable platform for analyzing factors influencing velocity‐based indices in the fetal cardiovascular system.
Navigating industrial performance: Impact of corporate social responsibility on sustainable development with moderation of reverse supply chain management
Authors: Tian Huawei , Pertheban Thillai Raja , Han Xuhui 
Published: October 2024

AbstractAlthough several studies ensured the essentiality of corporate social responsibility (CSR) with respect to sustainable development (SD) from various domains, worldwide. Nonetheless, this study explores the nexus among CSR practices (i.e., social responsibility, environmental responsibility, employee responsibility, customer responsibility, supplier responsibility, and govt. rules & regulation responsibility) on SD (i.e., social development, economic development, and environmental development) from the mainstream of Chinese industrial sector drawing on stakeholder theory. Second, this study investigates the moderating influence of reverse supply chain management (RSCM) to sense how these forces may impact the association between CSR and SD. After evaluation and by implementing a structural approach, the results affirmed the positive linkages between CSR and SD along with each CSR's dimension toward sustainable development. Finally, the study confirmed a positive connection of RSCM as a moderator between CSR and SD. Besides, certain implications are listed for the management along with shortcomings and future directions for academic scholars to extend studies for additional validation across the globe.