bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review and network meta‐analysis of immunotherapy and targeted therapy for advanced melanoma
Authors: da Silveira Nogueira Lima Joao Paulo , Georgieva Mina , Haaland Benjamin , de Lima Lopes Gilberto 
Published: May 2017

AbstractImmune and BRAF‐targeted therapies have changed the therapeutic scenario of advanced melanoma, turning the clinical decision‐making a challenging task. This Bayesian network meta‐analysis assesses the role of immunotherapies and targeted therapies for advanced melanoma. We retrieved randomized controlled trials testing immune, BRAF‐ or MEK‐targeted therapies for advanced melanoma from electronic databases. A Bayesian network model compared therapies using hazard ratio (HR) for overall survival (OS), progression‐free survival (PFS), and odds ratio (OR) for response rate (RR), along with 95% credible intervals (95% CrI), and probabilities of drugs outperforming others. We assessed the impact of PD‐L1 expression on immunotherapy efficacy. Sixteen studies evaluating eight therapies in 6849 patients were analyzed. For OS, BRAF‐MEK combination and PD‐1 single agent ranked similarly and outperformed all other treatments. For PFS, BRAF‐MEK combination surpassed all other options, including CTLA‐4‐PD‐1 dual blockade hazard ratio (HR: 0.56; 95% CrI: 0.33–0.97; probability better 96.2%), whereas BRAF single agent ranked close to CTLA‐4‐PD‐1 blockade. For RR, BRAF‐MEK combination was superior to all treatments including CTLA‐4‐PD‐1 (OR: 2.78; 1.18–6.30; probability better 97.1%). No OS data were available for CTLA‐4‐PD‐1 blockade at the time of systematic review, although PFS and RR results suggested that this combination could also bring meaningful benefit. PD‐L1 expression, as presently defined, failed to inform patient selection to PD‐1‐based immunotherapy. BRAF‐MEK combination seemed an optimal therapy for BRAF‐mutated patients, whereas PD‐1 inhibitors seemed optimal for BRAF wild‐type patients. Longer follow‐up is needed to ascertain the role of CTLA‐4‐PD‐1 blockade. Immunotherapy biomarkers remain as an unmet need.
Language as a cultural vessel in online servicescapes: Its impact on consumers' perceived risk, attitudes, and behavioural intentions
Authors: Alcántara‐Pilar Juan Miguel , Del Barrio‐García Salvador , Porcu Lucia , Crespo‐Almendros Esmeralda 
Published: May 2017

AbstractGlobalisation and the broader use of the Internet have led both academia and professionals to dedicate a great deal of attention to the analysis of the cultural differences that exist within a market and between different markets. Language emerges as a relevant issue in current marketing and communication management environments, especially in online servicescape. Following this premise, the current paper examines the role of language as a vessel of cultural values, namely, individualism and uncertainty avoidance, and its impact on consumer's perceived risk, attitudes, and behavioural intentions in online servicescape. To address this objective, an experimental design was performed. The sample comprised 491 Internet users from 2 different national cultures (British and Spanish). Users were asked to browse an experimental website in their native or first language, whereas the other half of the sample browsed in their second language (British subjects browsing in Spanish and vice versa). The unique contribution of this study lies in demonstrating that online information processing is moderated by the language by which users elaborate information and their cultural values in terms of the dimensions of individualism and uncertainty avoidance. The findings provide valuable insights into the role of language in international marketing strategies, as well as in multicultural and cross‐cultural integrated marketing communications. In this regard, marketers must acknowledge the symbolic cues of language and the competitive advantage that might derive from a strategic language choice to evoke emotions and forge attitudes that are consistent with brand and corporate values.
Runx2 alleviates high glucose‐suppressed osteogenic differentiation via PI3K/AKT/GSK3β/β‐catenin pathway
Authors: Chen Yang , Hu Yun , Yang Lan , Zhou Jie , Tang Yuying , Zheng Leilei , Qin Pu 
Published: May 2017

AbstractHyperglycemia is one of the most important pathogenesis of diabetic osteopathy. Several lines of studies indicate Runx2 plays a critical role in the process of osteogenic differentiation. However, little studies have analyzed the effect of Runx2 on osteoblast differentiation of rat bone mesenchymal stem cells (rBMSCs) in high‐glucose condition. In this study, the effect of Runx2 on osteoblast differentiation in high‐glucose condition was evaluated by the expression of osteogenesis‐related maker including Runx2, ALP, OC, and OPN, as well as ALP staining, ALP activity, and Alizarin red S staining. Western blot analysis was performed to detect the protein expression levels of p‐AKT, AKT, p‐GSK3β, GSK3β, and β‐catenin. Immunofluorescence staining analysis was performed to detect subcellular localization of β‐catenin. Our results revealed that high glucose significantly inhibited osteogenic differentiation, hyperosmolarity did not cause a suppression. In addition, Runx2 could upregulate the expression of osteogenic‐related genes and increase matrix mineralization, while applying 10 µM PI3K/AKT inhibitor LY294002 abolished the beneficial effect. Collectively, these results indicate that Runx2 alleviates high glucose‐induced inhibition of osteoblast differentiation by modulating PI3K/AKT/GSK3β/β‐catenin pathway.
Transradial versus transfemoral ancillary approach in complex structural, coronary, and peripheral interventions. Results from the multicenter ancillary registry: A study of the Italian Radial Club
Authors: Cortese Bernardo , Rigattieri Stefano , Aranzulla Tiziana C. , Russo Filippo , Latib Azeem , Burzotta Francesco , Agostoni Pierfrancesco , Ielasi Alfonso , Tarantino Fabio , Sticchi Alessandro , Di Palma Gaetano , de Benedictis Mauro , Trani Carlo , Boccaletti Roberto , Miccoli Rosa , Valsecchi Orazio , Colombo Antonio 
Published: May 2017

Objectivesto understand the role of a transradial (TR) secondary approach during complex percutaneous interventions.BackgroundThe value of the TR route for ancillary vascular approach has not been adequately validated in this setting, and there is scant data on its role in reducing bleeding complications.MethodsIn the present study we retrospectively included patients undergoing the following interventions requiring two vascular approaches at nine high‐volume centers in Italy: structural cardiac interventions, complex PCI, endovascular aortic repair (EVAR) and complex lower limb angioplasty. We compared procedural outcomes according to the type of ancillary vascular approach selected, namely TR or transfemoral/transbrachial (TF/TB). Primary endpoints of the study were procedural success and in‐hospital BARC grade 3–5 bleedings.ResultsWe included 906 patients, 433 receiving TR and 473 TF/TB ancillary approaches. Baseline characteristics did not differ significantly. Patients underwent the following types of intervention: structural 50%, complex coronary PCI 37%, EVAR 11%, peripheral angioplasty 2%. Procedural success was similar (90% in TR and 92% TF/TB, P = NS). In‐hospital BARC 3/5 bleedings were more common in TF/TB group as compared to TR group (19.7% vs. 6.7%,P < 0.001). In TF/TB group we also observed a higher postprocedural hemoglobin drop (1.92 vs 1.13 g/dl, P = 0.008) and longer hospital stay as compared to TR group. Similar results were observed in a propensity score‐matched population of 450 patients.ConclusionsIn our study TR ancillary approach was associated with a significant reduction in the risk of major bleedings, without jeopardizing the success of complex structural, coronary, and peripheral percutaneous interventions.The value of the transradial route for ancillary vascular approach during percutaneous interventions has not been adequately validated yet. We retrospectively included 906 patients, 433 receiving TR and 473 TF/TB ancillary approach at nine high‐volume centers for the following interventions: structural cardiac interventions, complex PCI, EVAR and complex peripheral angioplasty. Procedural success was similar, whereas in‐hospital BARC bleedings were more common in the transfemoral/brachial group. Similar results were observed in a propensity score‐matched population. In our study TR ancillary approach was associated with a significant reduction in the risk of major bleedings, without jeopardizing the success of complex interventions. © 2017 Wiley Periodicals, Inc.
Controllable Synthesis of CuxFe3−xO4@Cu Core–Shell Hollow Spherical Chains for Broadband, Lightweight Microwave Absorption
Authors: Wu Tong , Zhao Yanting , Li Yana , Wu Wenhua , Tong Guoxiu 
Published: May 2017

AbstractCuxFe3−xO4@Cu (0<x<1.30) core–shell hollow spherical chains (HSCs) with tunable composition were prepared through magnetic‐field‐induced solvothermal and liquid‐phase reduction approach. The influence of [Cu2+] on composition, phase, morphology, and microstructure of the products was confirmed by energy‐dispersive X‐ray spectrometry, X‐ray diffraction, X‐ray photoelectron spectrometry, scanning electron microscopy, and transmission electron microscopy analyses. Cu0 content, Cu2+ substitution, and crystal size in CuxFe3−xO4@Cu HSCs can be adjusted by changing [Cu2+]. Increasing [Cu2+] decreases the mean crystal size and increases the Cu0 content and Cu2+ substitution. The saturation magnetization (Ms) of CuxFe3−xO4@Cu HSCs linearly decreases, and the coercivity (Hc) varies in the Boltzmann mode. The microwave‐absorbing properties of CuxFe3−xO4@Cu HSCs decline first and then increase, and the sample with x=1.300 exhibits the optimal properties. Cu1.300Fe1.700O4@Cu HSCs with 44 wt % mass fraction obtain the minimum resonance loss (RL) of −45.1 dB at 3.44 GHz and the absorption bandwidth (RL≤−20 dB) of 9.9 GHz. Cu1.300Fe1.700O4@Cu HSCs exhibits stronger absorption, lighter weight, and a broader absorption band than the other samples. The improved absorption performance may be ascribed to the hollow/porous core–shell structures, Cu2+ substitution, and Cu0 shell with high conductivity, leading to enhanced permittivity, matching, and resonance absorption.
On the Meaning and Origins of Lignin Recalcitrance: A Critical Analysis of the Catalytic Upgrading of Lignins Obtained from Mechanocatalytic Biorefining and Organosolv Pulping
Authors: Calvaruso Gaetano , Clough Matthew T. , Rechulski Marcelo D. Kaufman , Rinaldi Roberto 
Published: May 2017

AbstractIn the broad context of catalysis for lignin valorization, the term “recalcitrance” is often used to describe the resistance of lignin to undergo chemical transformations (generally, reductive processes) rendering small molecules soluble in the reaction medium. Unfortunately, the current usage of the term “recalcitrance” often remains vague in meaning, hindering the search for better catalysts for lignin valorization. In the quest to address the research question—What is lignin recalcitrance?—we present our search for the factors responsible for the resistance of lignin to reductive catalytic processes, from various perspectives. In this study, lignins isolated as a precipitate obtained from the saccharification of water‐soluble lignocelluloses (produced by solvent‐free mechanocatalytic depolymerization of beechwood, pinewood, or sugarcane bagasse) and their counterparts isolated by solvent extraction (organosolv pulping) are investigated. The critical analysis of structure and bonding, in addition to the in‐depth understanding of results from the catalytic upgrading of lignin streams, in the presence of Raney Ni and H2 pressure under mild and extreme conditions, reveals that the simple evaluation of the total yield of liquid products provides no quantitative measure of the lignin recalcitrance. Our results shed light on the real meaning, origins and implications of “lignin recalcitrance” for catalysis research. The results demonstrate that lignin recalcitrance is associated not only with its intrinsic properties (i.e. molecular weight, the occurrence of native linkages, and their bond dissociation enthalpies) but also with its extrinsic properties (e.g. residual polysaccharides and solubility). Overall, this study presents a detailed evaluation of recalcitrance of lignin through the critical analysis of the product mixture properties (e.g. H/C and O/C ratios, molecular weight distribution, yield of key individual products, and several others).
Preparation of Magnesium‐Seamed C‐Alkylpyrogallol[4]arene Nanocapsules with Varying Chain Lengths
Authors: Zhang Chen , Patil Rahul S. , Li Tao , Barnes Charles L. , Teat Simon J. , Atwood Jerry L. 
Published: May 2017

AbstractNovel supramolecular nanocapsules based on metal‐directed assembly have captured tremendous interest due to their applications in fields such as catalysis, selective gas adsorption, and biomedicine. Functionalization of metal–organic nanocapsules (MONCs) by using organic ligands with different pendant groups affords more complexity to the structure and may lead to novel properties. In this work, we report the solvothermal synthesis of a group of magnesium‐based MONCs using C‐alkylpyrogallol[4]arenes with varying alkyl chain lengths. The structures of these nanocapsules are characterized by single‐crystal X‐ray diffraction analysis. As expected, a progression in size of the nanocapsules is observed as the alkyl chain length increases. The effect of the chain length on the solubility of MONCs in water has been determined. This work shows the generality of the solvothermal approach for the synthesis of MONCs with different organic ligands and demonstrates that surface functionalization of MONCs may serve as an effective way to tailor their properties. The unique biocompatible nature and inherent large cavity of these magnesium‐based MONCs make these nanocapsules promising for potential applications in biomedicine.
Modeling of Water Adsorption in SAPO‐34‐Coated Aluminum Foam
Authors: Bruckner Sven , Demmer Thomas , Ganswind Markus , Bathen Dieter 
Published: May 2017

AbstractAfter presenting the most promising continuous adsorption cooling topology for air‐conditioning of a passenger cabin, a transient, 3D model is proposed, based on a modified linear driving force approach, to simulate an adsorption process in a SAPO‐34‐coated open‐celled aluminum foam. The simulation is executed in ANSYS CFX 15.0 and the additional model equations are implemented through the CFX expression language. As a result the influence of the pore diameter onto the system simulation and the mass transport limitation is shown and the sensitivity concerning the pressure in the gas phase adsorption is confirmed.
Manufacturing of Industrial Zeolite Molecular Sieves
Authors: Gleichmann Kristin , Unger Baldur , Brandt Alfons 
Published: May 2017

AbstractZeolithische Molekularsiebe werden seit über 60 Jahren in industriellen Prozessen, hauptsächlich als hoch effiziente Adsorbenzien in Reinigungs‐ oder Trennprozessen in Gas‐ oder Flüssigphase eingesetzt. Um den unterschiedlichen Anforderungen in der Endanwendung Genüge zu tun, wurden im Laufe der Zeit unterschiedliche Herstellverfahren für Molekularsiebe entwickelt. In diesem Übersichtsartikel wird anhand von Beispielen der Einfluss von Synthese und/oder Formgebung auf die Eigenschaften hydrophiler, zeolithischer Molekularsiebe in Hinblick auf deren industriellen Anwendungen aufgezeigt und erläutert.
Association between echocardiographic epicardial fat thickness and circulating endothelial progenitor cell level in patients with stable angina pectoris
Authors: Chang Ting‐Yung , Hsu Chien‐Yi , Chiu Chun‐Chih , Chou Ruey‐Hsing , Huang Hsin‐Lei , Huang Chin‐Chou , Leu Hsin‐Ban , Huang Po‐Hsun , Chen Jaw‐Wen , Lin Shing‐Jong 
Published: May 2017

BackgroundEpicardial adipose tissue is associated with coronary artery disease (CAD). Circulating endothelial progenitor cell (EPC) level represents a marker of endothelial dysfunction and vascular health. However, the relationship between epicardial fat and circulating EPC remains unknown. This study aimed to investigate association between echocardiographic epicardial fat thickness (EFT) and circulating EPC level.HypothesisEpicardial fat causes inflammation and contributes to progression of CAD.MethodsWe enrolled 213 consecutive patients with stable angina, and EFT was determined by echocardiography. Quantification of EPC markers (defined as CD34
+, CD34
+
KDR
+, CD34
+
KDR
+
CD133
+ cells) in peripheral blood samples was used to measure circulating EPCs. All patients were divided into 3 tertiles according to EFT levels: group 1, low tertile of EFT; group 2, middle tertile of EFT; and group 3, high tertile of EFT.ResultsAmong the 3 groups, CAD disease severity determined by SXscore was negatively correlated with EFT, but the difference did not reach statistical significance (P = 0.066). Additionally, patients in the high and middle tertiles of EFT had higher circulating EPC levels than did those in the low tertile of EFT (P = 0.001 and P < 0.001, respectively). In multivariate analysis, EPC level was significantly associated with echocardiographic EFT (standardized β = −0.233, P = 0.001), independent of multiple covariates.ConclusionsEpicardial adipose tissue is associated with circulating EPC levels. There was a trend between epicardial fat and severity of CAD, though analysis did not reach statistical significance, and this may be attributed to the interaction between several risk factors of CAD.
Steroid–AuI–NHC Complexes: Synthesis and Antibacterial Activity
Authors: Vellé Alba , Maguire Ronan , Kavanagh Kevin , Sanz Miguel Pablo J. , Montagner Diego 
Published: May 2017

AbstractA series of gold(I) pioneer complexes bearing N‐heterocyclic carbenes and steroid derivatives (ethynylestradiol and ethisterone) with the generic formula [Au(R2‐imidazol‐2‐ylidene)(steroid)] (where R=CH3 or CH2CH2OCH3) were synthesized, and the X‐ray structure of a rare of gold(I)–estradiol derivative is discussed. Toxicity studies reveal notable antibacterial activity of the gold‐based compounds, which is significantly increased in vivo by the presence of the estradiol unit. Toxicity profiling was estimated in vitro versus Gram‐positive (Staphylococcus aureus) and Gram‐negative (Escherichia coli) bacteria, and in vivo on Galleria mellonella larvae against E. coli.
Association between insurance status at diagnosis and overall survival in chronic myeloid leukemia: A population‐based study
Authors: Perry Ashley M. , Brunner Andrew M. , Zou Tao , McGregor Kristin L. , Amrein Philip C. , Hobbs Gabriela S. , Ballen Karen K. , Neuberg Donna S. , Fathi Amir T. 
Published: May 2017

BACKGROUNDChronic myeloid leukemia (CML) can be treated effectively with tyrosine kinase inhibitor therapy directed at BCR‐ABL, but access to care, medication cost, and adherence may be barriers to treatment. This study was designed to determine whether the insurance status at diagnosis influences CML patient outcomes.METHODSThe Surveillance, Epidemiology, and End Results database was used to identify 5784 patients, aged 15 years or older, who were diagnosed with CML between 2007 and 2012 and whose insurance status was documented at diagnosis. The primary outcome was 5‐year overall survival (OS). Covariates of interest included the age at diagnosis, race, ethnicity, sex, county‐level socioeconomic status, and marital status. OS was evaluated with a log‐rank test and Kaplan‐Meier estimates.RESULTSAmong patients aged 15 to 64 years, insurance status was associated with OS (P < .001): being uninsured or having Medicaid was associated with worse 5‐year OS in comparison with being insured (uninsured patients, 72.7%; Medicaid patients, 73.1%; insured patients, 86.6%). For patients who were 65 years old or older, insurance had less of an impact on OS (P = .07), with similar 5‐year OS rates for patients with Medicaid and those with other insurance (40.2% vs 43.4%). In a multivariate analysis of patients aged 15 to 64 years, both uninsured patients (hazard ratio [HR], 1.93; P < .001) and Medicaid patients (HR, 1.83; P < .001) had an increased hazard of death in comparison with insured patients; patients younger than 40 years, female patients, and married patients also had a lower hazard of death.CONCLUSIONThese findings suggest that CML patients under the age of 65 years who are uninsured or have Medicaid have significantly worse survival than patients with other insurance coverage. Cancer 2017;123:2561–69. © 2017 American Cancer Society.
T‐cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death‐ligand 1 expression in patients with soft tissue sarcomas
Authors: Pollack Seth M. , He Qianchuan , Yearley Jennifer H. , Emerson Ryan , Vignali Marissa , Zhang Yuzheng , Redman Mary W. , Baker Kelsey K. , Cooper Sara , Donahue Bailey , Loggers Elizabeth T. , Cranmer Lee D. , Spraker Matthew B. , Seo Y. David , Pillarisetty Venu G. , Ricciotti Robert W. , Hoch Benjamin L. , McClanahan Terrill K. , Murphy Erin , Blumenschein Wendy M. , Townson Steven M. , Benzeno Sharon , Riddell Stanley R. , Jones Robin L. 
Published: May 2017

BACKGROUNDPatients with metastatic sarcomas have poor outcomes and although the disease may be amenable to immunotherapies, information regarding the immunologic profiles of soft tissue sarcoma (STS) subtypes is limited.METHODSThe authors identified patients with the common STS subtypes: leiomyosarcoma, undifferentiated pleomorphic sarcoma (UPS), synovial sarcoma (SS), well‐differentiated/dedifferentiated liposarcoma, and myxoid/round cell liposarcoma. Gene expression, immunohistochemistry for programmed cell death protein (PD‐1) and programmed death‐ligand 1 (PD‐L1), and T‐cell receptor Vβ gene sequencing were performed on formalin‐fixed, paraffin‐embedded tumors from 81 patients. Differences in liposarcoma subsets also were evaluated.RESULTSUPS and leiomyosarcoma had high expression levels of genes related to antigen presentation and T‐cell infiltration. UPS were found to have higher levels of PD‐L1 (P≤.001) and PD‐1 (P≤.05) on immunohistochemistry and had the highest T‐cell infiltration based on T‐cell receptor sequencing, significantly more than SS, which had the lowest (P≤.05). T‐cell infiltrates in UPS also were more oligoclonal compared with SS and liposarcoma (P≤.05). A model adjusted for STS histologic subtype found that for all sarcomas, T‐cell infiltration and clonality were highly correlated with PD‐1 and PD‐L1 expression levels (P≤.01).CONCLUSIONSIn the current study, the authors provide the most detailed overview of the immune microenvironment in sarcoma subtypes to date. UPS, which is a more highly mutated STS subtype, provokes a substantial immune response, suggesting that it may be well suited to treatment with immune checkpoint inhibitors. The SS and liposarcoma subsets are less mutated but do express immunogenic self‐antigens, and therefore strategies to improve antigen presentation and T‐cell infiltration may allow for successful immunotherapy in patients with these diagnoses. Cancer 2017;123:3291‐304. © 2017 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.