bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of B Value on Quantification of Rapid Diffusion Kurtosis Imaging in Normal and Acute Ischemic Brain Tissues
Authors: Chou Ming-Chung , Ko Cheng-Wen , Chiu Yu-Hsien , Chung Hsiao-Wen , Lai Ping-Hong 
Published: April 2017

Purpose
Diffusion kurtosis imaging (DKI) has been widely used to characterize brain tissue alterations. Diffusion-weighting factor or b value plays an important role in the measurement of rapid DKI and may have influential effects on them. The purpose of this study was to investigate the effects of b value on rapid DKI indices in normal and acute ischemic brain tissues.

Materials and Methods
This study enrolled 10 healthy subjects and 4 acute ischemic stroke patients. Three repeated DKI data with 6 high b values (500, 750, 1000, 1500, 2000, 3000 s/mm2) were acquired from healthy subjects, whereas nonrepeated DKI data with 3 high b values (1000, 2000, 3000 s/mm2) were acquired from ischemic stroke patients. The DKI datasets were decomposed into several rapid DKI datasets consisting of 1 b0 and 2 high b values for comparisons.

Results
The results showed that b value significantly impacted the reproducibility and accuracy of DKI indices. The comparisons demonstrated that DKI with b = (0, 1000, 3000) s/mm2 exhibited more reproducible and accurate DKI indices than other DKI datasets in normal brain tissues, and similar results were noticed in acute ischemic brain tissue.

Conclusions
We concluded that b value significantly impacted the quantification of DKI indices in both normal and acute ischemic brain tissues.
Inflow Angle of Small Paraophthalmic Aneurysms Is a Determinant of Adjacent Sphenoid Bone Remodeling
Authors: Giancaspro Gianni , Gagné Thierry , Tampieri Donatella , Cortes Maria DelPilar 
Published: April 2017

Objective
Large internal carotid artery aneurysms can cause remodeling of the sphenoid bone with subsequent hemorrhage into the sinus. No reports have demonstrated small unruptured lesions causing similar bone remodeling. The purpose of this study was to demonstrate our experience with small unruptured paraophthalmic aneurysms causing sphenoid bone remodeling, specifically when the optimal aneurysm inflow angle is present.

Methods
We searched our database for computed tomography angiography studies of small paraophthalmic aneurysms and assessed adjacent sphenoid bone remodeling and inflow angle.

Results
We found that aneurysms causing sphenoid remodeling represent 19.51% of all small paraophthalmic aneurysms at our institution and that the average inflow angle for these aneurysms was 94.38 degrees, significantly greater than for those not causing remodeling.

Conclusions
Our findings add support to using computed tomography angiography in the follow-up of aneurysms to assess surrounding bone changes and to the development of a more evidence-based approach in the management of small paraophthalmic aneurysms, which currently may be managed conservatively.
Cytoreductive Surgery for Metastatic Gastrointestinal Stromal Tumors Treated With Tyrosine Kinase Inhibitors
Authors: Fairweather Mark , Balachandran Vinod P. , Li George Z. , Bertagnolli Monica M. , Antonescu Cristina , Tap William , Singer Samuel , DeMatteo Ronald P. , Raut Chandrajit P. 
Published: April 2017

Objective:
To refine treatment recommendations for patients with metastatic gastrointestinal stromal tumors (GISTs) treated with tyrosine kinase inhibitors (TKIs) and surgery.

Background:
Early reports suggested that patients with metastatic GIST responding to TKIs treated with surgery may have favorable outcomes. However, identification of prognostic factors was limited by small cohorts.

Methods:
Progression-free survival (PFS) and overall survival (OS) from time of surgery and from start of initial TKI was determined. Multivariate analysis was conducted on all patients undergoing GIST metastasectomy between 2001 and 2014 at 2 institutions.

Results:
We performed 400 operations on 323 patients with metastatic GIST on TKIs. Radiographic response at time of surgery was classified as responsive disease (RD, n = 64, 16%), stable disease (SD, n = 100, 25%), unifocal progressive disease (UPD, n = 132, 33%), and multifocal progressive disease (MPD, n = 104, 26%). For patients on imatinib before surgery, radiographic response was predictive of PFS from time of surgery (RD 36 months, SD 30 months, UPD 11 months, MPD 6 months; P < 0.001) and from imatinib initiation (RD 71 months, SD 51 months, UPD 47 months, MPD 33 months; P < 0.001). Radiographic response was predictive of OS from time of surgery (RD not reached, SD 110 months, UPD 59 months, MPD 24 months; P < 0.001), and from imatinib initiation (RD not reached, SD 144 months, UPD 105 months, MPD 66 months; P = 0.005). Radiographic response was not predictive of PFS/OS for patients on sunitinib. Metastatic mitotic index ≥5/50 HPF, MPD, and R2 resection were prognostic of worse PFS/OS; primary mutation was not.

Conclusions:
Surgery in metastatic GIST patients in the absence of MPD on imatinib is associated with outcomes at least comparable with second-line sunitinib and may be considered in select patients.
Delirium Associated With Fluoxetine Discontinuation: A Case Report
Authors: Fan Kuang-Yuan , Liu Hsing-Cheng 
Published: April 2017

Background
Withdrawal symptoms on selective serotonin reuptake inhibitor (SSRI) discontinuation have raised clinical attention increasingly. However, delirium is rarely reported in the SSRI discontinuation syndrome.

Case
We report a case of delirium developing after fluoxetine discontinuation in a 65-year-old female patient with major depressive disorder. She experienced psychotic depression with limited response to treatment of fluoxetine 40 mg/d and quetiapine 100 mg/d for 3 months. After admission, we tapered fluoxetine gradually in 5 days because of its limited effect. However, delirious pictures developed 2 days after we stopped fluoxetine. Three days later, we added back fluoxetine 10 mg/d. Her delirious features gradually improved, and the clinical presentation turned into previous psychotic depression state. We gradually increased the medication to fluoxetine 60 mg/d and olanzapine 20 mg/d in the following 3 weeks. Her psychotic symptoms decreased, and there has been no delirious picture noted thereafter.

Conclusions
Delirium associated with fluoxetine discontinuation is a much rarer complication in SSRI discontinuation syndrome. The symptoms of SSRI discontinuation syndrome may be attributable to a rapid decrease in serotonin availability. In general, the shorter the half-life of any medication, the greater the likelihood patients will experience discontinuation symptoms. Genetic vulnerability might be a potential factor to explain that SSRI discontinuation syndrome also occurred rapidly in people taking long–half-life fluoxetine. The genetic polymorphisms of both pharmacokinetic and pharmacodynamic pathways might be potentially associated with SSRI discontinuation syndrome.
Plant cell wall integrity maintenance and pattern-triggered immunity modulate jointly plant stress responses in Arabidopsis thaliana
Authors: Engelsdorf Timo , Gigli-Bisceglia Nora , Veerabagu Manikandan , McKenna Joseph F. , Augstein Frauke , van der Does Dieuwertje , Zipfel Cyril , Hamann Thorsten 
Published: April 2017

AbstractPlant cells are surrounded by walls, which must often meet opposing functional requirements during plant growth and defense. The cells meet them by modifying wall structure and composition in a tightly controlled and adaptive manner. The modifications seem to be mediated by a dedicated cell wall integrity (CWI) maintenance mechanism. Currently the mode of action of the mechanism is not understood and it is unclear how its activity is coordinated with established plant defense signaling. We investigated responses to induced cell wall damage (CWD) impairing CWI and the underlying mechanism inArabidopsis thaliana.Interestingly inhibitor- and enzyme-derived CWD induced similar, turgor-sensitive stress responses. Genetic analysis showed that the receptor-like kinase (RLK) FEI2 and the mechano-sensitive, plasma membrane-localized Ca2+- channel MCA1 function downstream of the THE1 RLK in CWD perception. Phenotypic clustering with 27 genotypes identified a core group of RLKs and ion channels, required for activation of CWD responses. By contrast, the responses were repressed by pattern-triggered immune (PTI) signaling components including PEPR1 and 2, the receptors for the immune signaling peptideAtPep1. InterestinglyAtPep1 application repressed CWD-induced phytohormone accumulation in aPEPR1/2-dependent manner. These results suggest that PTI suppresses CWD-induced defense responses through elicitor peptide-mediated signaling during defense response activation. If PTI is impaired, the suppression of CWD-induced responses is alleviated, thus compensating for defective PTI.Significance statementStress resistance and plant growth determine food crop yield and efficiency of bioenergy production from ligno-cellulosic biomass. Plant cell walls are essential elements of the biological processes, therefore functional integrity of the cell walls must be maintained throughout. Here we investigate the plant cell wall integrity maintenance mechanism. We characterize its mode of action, identify essential signaling components and show that theAtPep1 signaling peptide apparently coordinates pattern triggered immunity (PTI) and cell wall integrity maintenance in plants. These results suggest how PTI and cell wall modification coordinately regulate biotic stress responses with plants possibly compensating for PTI impairment through enhanced activation of stress responses regulated by the CWI maintenance mechanism.
A novel k-mer set memory (KSM) motif representation improves regulatory variant prediction
Authors: Guo Yuchun , Tian Kevin , Zeng Haoyang , Guo Xiaoyun , Gifford David Kenneth 
Published: April 2017

ABSTRACTThe representation and discovery of transcription factor (TF) sequence binding specificities is critical for understanding gene regulatory networks and interpreting the impact of disease-associated non-coding genetic variants. We present a novel TF binding motif representation, the K-mer Set Memory (KSM), which consists of a set of aligned k-mers that are over-represented at TF binding sites, and a new method called KMAC forde novodiscovery of KSMs. We find that KSMs more accurately predict in vivo binding sites than position weight matrix models (PWMs) and other more complex motif models across a large set of ChIP-seq experiments. KMAC also identifies correct motifs in more experiments than four state-of-the-art motif discovery methods. In addition, KSM derived features outperform both PWM and deep learning model derived sequence features in predicting differential regulatory activities of expression quantitative trait loci (eQTL) alleles. Finally, we have applied KMAC to 1488 ENCODE TF ChIP-seq datasets and created a public resource of KSM and PWM motifs. We expect that the KSM representation and KMAC method will be valuable in characterizing TF binding specificities and in interpreting the effects of non-coding genetic variations.
Arc restores juvenile plasticity in adult mouse visual cortex
Authors: Jenks Kyle R. , Kim Taekeun , Pastuzyn Elissa D. , Okuno Hiroyuki , Taibi Andrew V. , Bito Haruhiko , Bear Mark F. , Shepherd Jason D. 
Published: April 2017

AbstractThe molecular basis for the decline in experience-dependent neural plasticity over age remains poorly understood. In visual cortex, the robust plasticity induced in juvenile mice by brief monocular deprivation (MD) during the critical period is abrogated by genetic deletion of Arc, an activity-dependent regulator of excitatory synaptic modification. Here we report that augmenting Arc expression in adult mice prolongs juvenile-like plasticity in visual cortex, as assessed by recordings of ocular dominance (OD) plasticityin vivo. A distinguishing characteristic of juvenile OD plasticity is the weakening of deprived-eye responses, believed to be accounted for by the mechanisms of homosynaptic long-term depression (LTD). Accordingly, we also found increased LTD in visual cortex of adult mice with augmented Arc expression, and impaired LTD in visual cortex of juvenile mice that lack Arc or have been treatedin vivowith a protein synthesis inhibitor. Further, we found that although activity-dependent expression ofArcmRNA does not change with age, expression of Arc protein is maximal during the critical period and declines in adulthood. Finally, we show that acute augmentation of Arc expression in wild type adult mouse visual cortex is sufficient to restore juvenile-like plasticity. Together, our findings suggest a unifying molecular explanation for the age- and activity-dependent modulation of synaptic sensitivity to deprivation.Significance StatementNeuronal plasticity peaks early in life during critical periods and normally declines with age, but the molecular changes that underlie this decline are not fully understood. Using the mouse visual cortex as a model, we found that activity-dependent expression of the neuronal protein Arc peaks early in life, and that loss of activity-dependent Arc expression parallels loss of synaptic plasticity in the visual cortex. Genetic overexpression of Arc prolongs the critical period of visual cortex plasticity and acute viral expression of Arc in adult mice can restore juvenile-like plasticity. These findings provide a mechanism for the loss of excitatory plasticity with age, and suggest that Arc may be an exciting therapeutic target for modulation of the malleability of neuronal circuits.
Association mapping and haplotype analysis of the pre-harvest sprouting resistance locusPhs-A1reveals a causal role ofTaMKK3-Ain global germplasm
Authors: Shorinola Oluwaseyi , Balcárková Barbara , Hyles Jessica , Tibbits Josquin F. G. , Hayden Matthew J. , Holušova Katarina , Valárik Miroslav , Distelfeld Assaf , Torada Atsushi , Barrero Jose M. , Uauy Cristobal 
Published: April 2017

AbstractPre-harvest sprouting (PHS) is an important cause of quality loss in many cereal crops and is particularly prevalent and damaging in wheat. Resistance to PHS is therefore a valuable target trait in many breeding programmes. ThePhs-A1locus on wheat chromosome arm 4AL has been consistently shown to account for a significant proportion of natural variation to PHS in diverse mapping populations. However the deployment of sprouting resistance is confounded by the fact that different candidate genes, including the tandem duplicatedPlasma Membrane 19 (PM19)genes and themitogen-activated protein kinase kinase 3 (TaMKK3-A)gene, have been proposed to underliePhs-A1. To further define thePhs-A1locus, we constructed a physical map across this interval in hexaploid and tetraploid wheat. We established close proximity of the proposed candidate genes which are located within a 1.2 Mb interval. An association analysis of diverse germplasm used in previous genetic mapping studies suggests thatTaMKK3-A, and notPM19, is the major gene underlying thePhs-A1effect in European, North American, Australian and Asian germplasm. We identified the non-dormantTaMKK3-Aallele at low frequencies within the A-genome diploid progenitorTriticum urartugenepool, and show an increase in the allele frequency in modern varieties. In UK varieties, the frequency of the dormantTaMKK3-Aallele was significantly higher in bread-making quality varieties compared to feed and biscuit-making cultivars. Analysis of exome capture data from 58 diverse hexaploid wheat accessions identified fourteen haplotypes across the extendedPhs-A1locus and four haplotypes forTaMKK3-A. Analysis of these haplotypes in a collection of UK and Australian cultivars revealed distinct major dormant and non-dormantPhs-A1haplotypes in each country, which were either rare or absent in the opposing germplasm set. The diagnostic markers and haplotype information reported in the study will help inform the choice of germplasm and breeding strategies for the deployment ofPhs-A1resistance into breeding germplasm.
Visual context modulates action perception in 10-month-old infants
Authors: Bache Cathleen , Noack Hannes , Springer Anne , Stadler Waltraud , Kopp Franziska , Lindenberger Ulman , Werkle-Bergner Markus 
Published: April 2017

AbstractResearch on early action perception has documented infants’ astounding abilities in tracking, predicting, and understanding other people’s actions. Common interpretations of previous findings tend to generalize across a wide range of action stimuli and contexts. In this study, ten-month-old infants repeatedly watched a video of a same-aged crawling baby that was transiently occluded. The video was presented in alternation with videos displaying visually either dissimilar movements (i.e., distorted human, continuous object, and distorted object movements) or similar movements (i.e., delayed or forwarded versions of the crawling video). Eye-tracking behavior and rhythmic neural activity, reflecting attention (posterior alpha), memory (frontal theta), and sensorimotor simulation (central alpha), were concurrently assessed. Results indicate that, when the very same movement was presented in a dissimilar context, it was tracked at more rear parts of the target and posterior alpha activity was elevated, suggesting higher demands on attention-controlled information processing. We conclude that early action perception is not immutable but shaped by the immediate visual context in which it appears, presumably reflecting infants’ ability to flexibly adjust stimulus processing to situational affordances.
Necroptosis promotes the Aging of the Male Reproductive System in Mice
Authors: Li Dianrong , Meng Lingjun , Xu Tao , Su Yaning , Liu Xiao , Zhang Zhiyuan , Wang Xiaodong 
Published: April 2017

AbstractNecroptosis is a form of programmed necrotic cell death in mammals that is mediated by a pair of kinases, RIP1 and RIP3, as well as the RIP3 substrate MLKL. We report here that male reproductive organs of both RIP3-and MLKL-knockout mice retain “youthful” morphology and function into advanced age, while those of age-matched wild type mice deteriorate. The RIP3 phosphorylation of MLKL, the activation marker of necroptosis, is detected in spermatogonial stem cells in the testes of old but not in young wild type mice. When the testes of young wild type mice are given a local necroptotic stimulus, their reproductive organs showed accelerated aging. Feeding of wild type mice with an RIP1 inhibitor prior to the normal onset of age-related changes in their reproductive organs blocked the appearance of signs of aging. Thus, necroptosis in testes promotes the aging-associated deterioration of the male reproductive system in mice.
Does big data analytics influence frontline employees in services marketing?
Authors: Motamarri Saradhi , Akter Shahriar , Yanamandram Venkat 
Published: April 2017

Purpose
Big data analytics (BDA) helps service providers with customer insights and competitive information. It also empowers customers with insights about the relative merits of competing services. The purpose of this paper is to address the research question, “How does big data analytics enable frontline employees (FLEs) in effective service delivery?”

Design/methodology/approach
The research develops schemas to visualise service contexts that potentially benefit from BDA, based on the literature drawn from BDA and FLEs streams.

Findings
The business drivers for BDA and its level of maturity vary across firms. The primary thrust for BDA is to gain customer insights, resource optimisation and efficient operations. Innovative FLEs operating in knowledge intensive and customisable settings may realise greater value co-creation.

Practical implications
There exists a considerable knowledge gap in enabling the FLEs with BDA tools. Managers need to train, orient and empower FLEs to collaborate and create value with customer interactions. Service-dominant logic posits that skill asymmetry is the reason for service. So, providers need to enhance skill levels of FLEs continually. Providers also need to focus on market sensing and customer linking abilities of FLEs.

Social implications
Both firms and customers need to be aware of privacy and ethical concerns associated with BDA.

Originality/value
Knitting the BDA and FLEs research streams, the paper analyses the impact of BDA on service. The research by developing service typology portrays its interplay with the typologies of FLEs and BDA. The framework portrays the service contexts in which BD has major impact. Looking further into the future, the discussion raises prominent questions for the discipline.
Reflection on the UN General Assembly Special Session on drugs – one year on
Authors: Rolles Steve 
Published: April 2017

Purpose
The purpose of this paper is to show a reflection of one year on how the UN General Assembly Special Session (UNGASS) event was unfolded and its impacts and longer term implications.

Design/methodology/approach
This paper is a consideration of relevant past and present documentation and commentary. Experiences as a participant at some of the events described.

Findings
UNGASS was called for by countries affected by the failings of the existing conventions who wanted to introduce reformed alternative policies. Representatives of the status quo who opposed such change were partially successful in retaining some aspects of the prohibition approach and in minimising dissent and debate.

Research limitations/implications
Some decision-making discussions were not open to all potential participants – governmental, regional and civil society, including the author.

Practical implications
The wider debate prompted by the UNGASS indicated a breakdown in the previous consensus around the prohibition and punitive paradigm of the international conventions.

Social implications
Greater emphases on health and human rights aspects of international drug policy were included in the final documents. This provides scope for continued evolution of these emphases in the future.

Originality/value
The paper presents an account of the UNGASS and pre-UNGASS proceedings from the point of view of a reform-minded participant.
“Respect” and “self-determination” women entrepreneurs’ identities and entrepreneurial discourses
Authors: Fernandes Emilia , Mota-Ribeiro Silvana 
Published: April 2017

Purpose
This exploratory study aims to compare how businesswomen with different initial bounds to their businesses resort to gender discourses to construct a shared business identity in group interaction.

Design/methodology/approach
The study was conducted with two focus groups of Portuguese businesswomen with different initial bounds to their enterprises: those who created their own companies and those who “inherited” family businesses. All the participants of both groups own and manage their businesses.

Findings
A discourse analysis of the interactions shows that the identities of businesswomen are constrained and produced by different masculinities (authority, professionalism and self-determination) and femininities (restrictive and emancipatory). The interweaving of these gender discourses results in the production of a “respect” identity in the family businesses group and a “self-determination” identity in the start-up businesses group.

Practical implications
The comparison of the different business identities shared by women with particular business experiences contributes to reflections upon the diversified contours that gender discrimination can undertake, and upon the need of practitioners to adjust the gender policies according to those particular experiences.

Originality/value
The paper compares and highlights how Portuguese businesswomen with different business backgrounds collectively construct specific and shared business identities that allow them to deal with diverse experiences of gender discrimination and devaluation.