bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intragenic amplification of PAX5: a novel subgroup in B-cell precursor acute lymphoblastic leukemia?
Authors: Schwab Claire , Nebral Karin , Chilton Lucy , Leschi Cristina , Waanders Esmé , Boer Judith M. , Žaliová Markéta , Sutton Rosemary , Öfverholm Ingegerd Ivanov , Ohki Kentaro , Yamashita Yuka , Groeneveld-Krentz Stefanie , Froňková Eva , Bakkus Marleen , Tchinda Joelle , Barbosa Thayana da Conceição , Fazio Grazia , Mlynarski Wojciech , Pastorczak Agata , Cazzaniga Giovanni , Pombo-de-Oliveira Maria S. , Trka Jan , Kirschner-Schwabe Renate , Imamura Toshihiko , Barbany Gisela , Stanulla Martin , Attarbaschi Andishe , Panzer-Grümayer Renate , Kuiper Roland P. , den Boer Monique L. , Cavé Hélène , Moorman Anthony V. , Harrison Christine J. , Strehl Sabine 
Published: August 2017

Key Points
Intragenic PAX5 amplification defines a novel, relapse-prone subtype of B-cell precursor acute lymphoblastic leukemia with a poor outcome.
Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update
Authors: Hanna Nasser , Johnson David , Temin Sarah , Baker Sherman , Brahmer Julie , Ellis Peter M. , Giaccone Giuseppe , Hesketh Paul J. , Jaiyesimi Ishmael , Leighl Natasha B. , Riely Gregory J. , Schiller Joan H. , Schneider Bryan J. , Smith Thomas J. , Tashbar Joan , Biermann William A. , Masters Gregory 
Published: August 2017

Purpose Provide evidence-based recommendations updating the 2015 ASCO guideline on systemic therapy for patients with stage IV non–small-cell lung cancer (NSCLC). Methods The ASCO NSCLC Expert Panel made recommendations based on a systematic review of randomized controlled trials from February 2014 to December 2016 plus the Cancer Care Ontario Program in Evidence-Based Care’s update of a previous ASCO search. Results This guideline update reflects changes in evidence since the previous guideline update. Fourteen randomized controlled trials provide the evidence base; earlier phase trials also informed recommendation development. Recommendations New or revised recommendations include the following. Regarding first-line treatment for patients with non–squamous cell carcinoma or squamous cell carcinoma (without positive markers, eg, EGFR/ALK /ROS1), if the patient has high programmed death ligand 1 (PD-L1) expression, pembrolizumab should be used alone; if the patient has low PD-L1 expression, clinicians should offer standard chemotherapy. All other clinical scenarios follow 2015 recommendations. Regarding second-line treatment in patients who received first-line chemotherapy, without prior immune checkpoint therapy, if NSCLC tumor is positive for PD-L1 expression, clinicians should use single-agent nivolumab, pembrolizumab, or atezolizumab; if tumor has negative or unknown PD-L1 expression, clinicians should use nivolumab or atezolizumab. All immune checkpoint therapy is recommended alone plus in the absence of contraindications. For patients who received a prior first-line immune checkpoint inhibitor, clinicians should offer standard chemotherapy. For patients who cannot receive immune checkpoint inhibitor after chemotherapy, docetaxel is recommended; in patients with nonsquamous NSCLC, pemetrexed is recommended. In patients with a sensitizing EGFR mutation, disease progression after first-line epidermal growth factor receptor tyrosine kinase inhibitor therapy, and T790M mutation, osimertinib is recommended; if NSCLC lacks the T790M mutation, then chemotherapy is recommended. Patients with ROS1 gene rearrangement without prior crizotinib may be offered crizotinib, or if they previously received crizotinib, they may be offered chemotherapy.
An analysis of characteristics of post-authorisation studies registered on the ENCePP EU PAS Register
Authors: Carroll Robert , Ramagopalan Sreeram V. , Cid-Ruzafa Javier , Lambrelli Dimitra , McDonald Laura 
Published: August 2017

Background: The objective of this study was to investigate the study design characteristics of Post-Authorisation Studies (PAS) requested by the European Medicines Agency which were recorded on the European Union (EU) PAS Register held by the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP). Methods: We undertook a cross-sectional descriptive analysis of all studies registered on the EU PAS Register as of 18th October 2016. Results: We identified a total of 314 studies on the EU PAS Register, including 81 (26%) finalised, 160 (51%) ongoing and 73 (23%) planned. Of those studies identified, 205 (65%) included risk assessment in their scope, 133 (42%) included drug utilisation and 94 (30%) included effectiveness evaluation. Just over half of the studies (175; 56%) used primary data capture, 135 (43%) used secondary data and 4 (1%) used a hybrid design combining both approaches. Risk assessment and effectiveness studies were more likely to use primary data capture (60% and 85% respectively as compared to 39% and 14% respectively for secondary). The converse was true for drug utilisation studies where 59% were secondary vs. 39% for primary. For type 2 diabetes mellitus, database studies were more commonly used (80% vs 3% chart review, 3% hybrid and 13% primary data capture study designs) whereas for studies in oncology, primary data capture were more likely to be used (85% vs 4% chart review, and 11% database study designs). Conclusions: Results of this analysis show that study objectives and therapeutic area influence PAS design in terms of type of data capture used.
If You Book It, Will They Come? Attendance at Postdischarge Follow‐Up Visits Scheduled by Inpatient Providers
Authors: Banerjee Rahul , Suarez Alex , Kier Melanie , Jr. Steve Honeywell , Feng Weiwei , Mitra Nandita , Grande David T. , Myers Jennifer S. 
Published: August 2017

BACKGROUNDPostdischarge follow‐up visits (PDFVs) are widely recommended to improve inpatient‐outpatient transitions of care.OBJECTIVETo measure PDFV attendance rates.DESIGNObservational cohort study.SETTINGMedical units at an academic quaternary‐care hospital and its affiliated outpatient clinics.PATIENTSAdult patients hospitalized between April 2014 and March 2015 for whom at least 1 PDFV with our health system was scheduled. Exclusion criteria included nonprovider visits, visits cancelled before discharge, nonaccepted health insurance, and visits scheduled for deceased patients.MEASUREMENTSThe study outcome was the incidence of PDFVs resulting in no‐shows or same‐day cancellations (NS/SDCs).RESULTSOf all hospitalizations, 6136 (52%) with 9258 PD‐FVs were analyzed. Twenty‐five percent of PDFVs were NS/SDCs, 23% were cancelled before the visit, and 52% were attended as scheduled. In multivariable regression models, NS/SDC risk factors included black race (odds ratio [OR] 1.94, 95% confidence interval [CI], 1.63‐2.32), longer lengths of stay (hospitalizations ≥15 days: OR 1.51, 95% CI, 1.22‐1.88), and discharge to facility (OR 2.10, 95% CI, 1.70‐2.60). Conversely, NS/SDC visits were less likely with advancing age (age ≥65 years: OR 0.39, 95% CI, 0.31‐0.49) and driving distance (highest quartile: OR 0.65, 95% CI, 0.52‐0.81). Primary care visits had higher NS/SDC rates (OR 2.62, 95% CI, 2.03‐3.38) than oncologic visits. The time interval between discharge and PDFV was not associated with NS/SDC rates.CONCLUSIONSPDFVs were scheduled for more than half of hospitalizations, but 25% resulted in NS/SDCs. New strategies are needed to improve PDFV attendance.
We Want to Know: Eliciting Hospitalized Patients' Perspectives on Breakdowns in Care
Authors: Fisher Kimberly A. , Smith Kelly M. , Gallagher Thomas H. , Burns Laura , MS Crystal Morales , Mazor Kathleen M. 
Published: August 2017

BACKGROUNDThere is increasing recognition that patients have critical insights into care experiences, including about breakdowns in care. Harnessing patient perspectives for hospital improvement requires an in‐depth understanding of the types of breakdowns patients identify and the impact of these events.METHODSWe interviewed a broad sample of patients during hospitalization and postdischarge to elicit patient perspectives on breakdowns in care. Through an iterative process, we developed a categorization of patient‐perceived breakdowns called the Patient Experience Coding Tool.RESULTSOf 979 interviewees, 386 (39.4%) believed they had experienced at least one breakdown in care. The most common reported breakdowns involved information exchange (n = 158; 16.1%), medications (n = 120; 12.3%), delays in admission (n = 90; 9.2%), team communication (n = 65; 6.6%), providers' manner (n = 62; 6.3%), and discharge (n = 56; 5.7%). Of the 386 interviewees who reported a breakdown, 140 (36.3%) perceived associated harm. Patient‐perceived harms included physical (eg, pain), emotional (eg, distress, worry), damage to relationship with providers, need for additional care or prolonged hospital stay, and life disruption. We found higher rates of reporting breakdowns among younger (<60 years old) patients (45.4% vs 34.5%; P < .001), those with at least some college education (46.8% vs 32.7%; P < .001), and those with another person (family or friend) present during the interview or interviewed in lieu of the patient (53.4% vs 37.8%; P = .002).CONCLUSIONSWhen asked directly, almost 4 out of 10 hospitalized patients reported a breakdown in their care. Patient‐perceived breakdowns in care are frequently associated with perceived harm, illustrating the importance of detecting and addressing these events.
A Contemporary Assessment of Mechanical Complication Rates and Trainee Perceptions of Central Venous Catheter Insertion
Authors: Heidemann Lauren , Nathani Niket , Sagana Rommel , Chopra Vineet , Heung Michael 
Published: August 2017

BACKGROUNDLimited data exist regarding rates of mechanical complications of ultrasound‐guided, nontunneled central venous catheters (CVC). Similarly, trainee perceptions surrounding CVC complications are largely unknown.OBJECTIVESTo evaluate contemporary CVC mechanical complication rates, associated risk factors, and trainee perspectives.DESIGNA single‐center retrospective review of CVC procedures between June 1, 2014, and May 1, 2015. Electronic survey distributed to internal medicine trainees.SETTINGIntensive care units and the emergency department at an academic hospital.MEASUREMENTSElectronic health records of patients with CVC procedures were reviewed for complications. Demographic and procedural characteristics were compared for complicated vs uncomplicated procedures. Student t tests and chi‐square tests were used to compare continuous and categorical variables, respectively.RESULTSOf the 730 reviewed records, 14 serious mechanical complications occurred due to pneumothorax (n = 5), bleeding (n = 3), vascular injury (n = 3), stroke (n = 1), and death (n = 2). Risk factors for complicated vs uncomplicated CVC placement included subclavian location (21.4% vs 7.8%, P = 0.001), number of attempts (2.2 vs 1.5, P = 0.02), unsuccessful CVC (21.4% vs. 4.3%, P = 0.001), attending supervision (61.5% vs 34.7%, P = 0.04), low body mass index (mean 25.7 kg/m2 vs 31.5 kg/m2, P = 0.001), anticoagulation (28.6% vs 20.6%, P = 0.048), and ventilation (78.5% vs 66.5%, P = 0.001). Survey data suggested deficiencies in managing unsuccessful CVC procedures; specifically, only 35% (N = 21/60) of trainees regularly perform chest x‐rays after failed CVC attempt.CONCLUSIONSWe observed a 1.9% rate of mechanical complications associated with CVC placement. Our study confirms historical data that unsuccessful CVC attempts are an important risk factor for complications. Education regarding unsuccessful CVC placement may improve patient safety.
Országos Táplálkozás- és Tápláltsági Állapot Vizsgálat – OTÁP2014. V. A magyar lakosság vitaminbevitele
Authors: Schreiberné Molnár Erzsébet , Nagy-Lőrincz Zsuzsanna , Nagy Barbara , Bakacs Márta , Kis Orsolya , Sarkadi Nagy Eszter , Martos Éva 
Published: August 2017

Abstract: Introduction and aim: The Hungarian Diet and Nutritional Status Survey was implemented on a sub-sample of the European Health Interview Survey. In this paper, the authors present the data on the vitamin intake of the Hungarian population. Method: The survey represents the vitamin intake of the Hungarian non-institutionalised adult population of 18 years and older. There are significant differences between men’s and women’s vitamin intake. Results: The intake of all water-soluble vitamins except for vitamin C is higher in men than in women, and the difference between the genders regarding the intake of vitamin E and D is significant. The intake of vitamin B1, B2, B6, B12, niacin and vitamin C is in line with the recommendations, however, there is an unfavourable decrease in the intake of vitamin A and β-carotene in the case of men compared to the previous survey. Vitamin D and folic acid intakes are critically low, particularly in the elderly, and mainly in case of vitamin D. The population’s intake of panthotenic acid and biotin did not reach the recommendations. Conclusion: In order to reach the dietary reference intakes and to prevent deficiencies, it is necessary to inform the population and to make healthy food choices available. Orv Hetil. 2017; 158(33): 1302–1313.
INCREASING THE LEVEL OF ENVIRONMENTAL EFFICIENCY OF INDUSTRY IS THE IMPORTANT RESULT OF ITS FUNCTIONING CONTROL
Authors: Voinova S. A. , Dets D. V. 
Published: August 2017

The modern complex state of the natural environment, caused by the harmful impact of the rapidly developing world industry on it, is considered. It is pointed out the acute urgency of the utmost reduction of the harmful effects of industry. It is noted that the world's power engineering is the most active source of harmful effects increasing with acceleration on living and non-living nature. The ecological essence of the concept of energy saving is revealed. It is shown that high-quality control of the operation of technical objects is a productive means of increasing the level of ecological efficiency of enterprise operations. A chain of interrelated circumstances that determines the strict dependence of the degree of environmental friendliness of a technical object on the quality of the control process of its operation is considered. The issues of ecological modernization of the enterprise as a means of increasing the ecological efficiency of its enterprise activities are considered. There are specified the components of the company's environmental efficiency in accordance with the state standard.
TINJAUAN DALAM RENCANA PEMBERLAKUAN GREEN TAX ATAU ECO TAX DI INDONESIA UNTUK MENGHADAPI ASEAN ECONOMIC COMMUNITY 2015
Authors: Eva Mustika Pratiwi Eva , Setyawan Gadhang 
Published: August 2017

ASEAN Economic Community (AEC) is a community of nations in Southeast Asia who are members of ASEAN. In addition to cooperation in the economic field, the ASEAN Economics Community is also working in the field of defense and security as well as social and cultural. In the socio-cultural cooperation, ASEAN Community is also concerned about environmental decline. One of the policies that can be used to overcome this problem is Green Tax or Eco Tax while the instrument can be used for environmental management ISO 14000. This study uses descriptive qualitative research methods research by studying the symptoms, then the problem interpret or infer meaning a combination of various problems as presented by the situation based on the relevant studies. This research aims to analyze the benefits of the imposition of the Green Tax or Eco Tax in Indonesia and analyze the implementation of the Green Tax or Tax Eco good so it can accommodate entrepreneurs interested and the environment in the face of ASEAN Economic Community 2015.
PENGARUH IMPLEMENTASI SISTEM PENGENDALIAN INTERNAL TERHADAP KINERJA INSTANSI PEMERINTAH (STUDI KASUS PADA ORGANISASI PERANGKAT DAERAH PEMERINTAH KOTA BANDUNG)
Authors: Supriatna Nono 
Published: August 2017

Abstract. This research is intended to know the influence. This research is conducted because it is still related to the fraud and inefficiency of government apparatus performance in Bandung. This study uses a sample of Organization of Local Government of Bandung City Government in the form of agency and agency. This research uses descriptive verification method with hypothesis test using simple linear regression analysis. The results showed that in Bandung City has done very well. In addition, the performance performance of Bandung City Government apparatus has also been in accordance with the principle of good governance. The results also show a positive influence. H0 rejected and Ha accepted. Keywords: Internal Control System, Performance, Good Governance. Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh implementasi sistem pengendalian internal terhadap kinerja instansi pemerintah. Penelitian ini dilakukan karena masih adanya indikasi terkait dengan kecurangan dan inefisiensi kinerja aparatur pemerintah di Kota Bandung. Penelitian ini menggunakan sample Organisasi Perangkat Daerah Pemerintah Kota Bandung yang berbentuk dinas dan badan sejumlah 23 sample. Penelitian ini menggunakan metode deskriptif verifikatif dengan uji hipotesis menggunakan analisis regresi linier sederhana. Hasil penelitian menunjukan bahwa penerapan sistem pengendalian internal di pemerintah Kota Bandung telah terlaksana dengan sangat baik. Selain itu, pelaksanaan kinerja aparatur Pemerintah Kota Bandung juga telah sesuai dengan prinsip good governance. Hasil penelitian juga menunjukan bahwa terdapat pengaruh positif antara implementasi sistem pengendalian internal terhadap kinerja instansi pemerintah. Sehingga H0 ditolak dan Ha diterima Kata Kunci: Sistem Pengendalian Internal, Kinerja, Good Governance
PENGARUH LABA AKUNTANSI, KOMPONEN ARUS KAS, DAN DIVIDEND YIELD TERHADAP RETURN SAHAM (STUDI PADA PERUSAHAAN SEKTOR PERTAMBANGAN DI BURSA EFEK INDONESIA PERIODE 2012-2014)
Authors: Rahmanda Putra Yogie , Widyaningsih Mimin 
Published: August 2017

Penelitian ini bertujuan untuk menganalisis pengaruh Laba Akuntansi, Komponen Arus Kas, dan Dividend Yield terhadap Return saham pada perusahaan Pertambangan yang terdaftar di Bursa Efek Indonesia periode 2012-2014. Variable yang diteliti dalam penelitian ini adalah Laba akuntansi, Arus kas operasi, Arus kas investasi, Arus kas pendanaan, dan Dividend yield sebagai variable independen; Return Saham sebagai variable dependen. Metode penelitian yang digunakan adalah metode statistik deskriptif. Dengan pengujian verifikatif menggunakan regresi berganda (multiple regression). Data yang digunakan merupakan data sekunder yaitu laporan tahunan perusahaan yang dijadikan sampel dalam penelitian. Sampel penelitian merupakan 12 perusahaan Sektor Pertambangan yang terdaftar di Bursa Efek Indonesia Tahun 2011-2014 yang diambil dengan menggunakan metode purposive sampling. Hasil penelitian ini menunjukkan bahwa Laba akuntansi, Arus kas operasi, Arus kas investasi, Arus kas pendanaan, dan Dividend yield berpengaruh positif terhadap Return saham.
Utility of autoantibodies in insulin-dependent diabetes mellitu
Authors: Akhmedov G A 
Published: August 2017

Aim. To study relationship of levels of autoantibodies GAD 65, IА-2 and С-peptide with DRB1_1 and DRB1_2 genotypes of human leukocyte antigen and presence of ketoacidosis in children with newly diagnosed diabetes mellitus among the population of Azerbaijan.
Methods. 128 children with newly diagnosed diabetes mellitus were examined. The average age of children was 8.7±0.40 years. GAD 65 and IA-2 autoantibodies were measured.
Results. During the study no correlation between concentration of autoantibodies GAD 65 and IA-2 was found (r=0.067, p=0.46). Also no correlation was revealed between GAD 65 autoantibodies and C-peptide concentration (r=+0.025, p=0.011). Comparison of HLA DRB1_1 and DRB1_2 autoantibodies in 106 children also demonstrated no correlation. At the same time, positive correlation was found between glucose level and GAD 65 (r=+0.21, p=0.02). In children without ketoacidosis, but with high IA-2 (n=9) negative correlation with HbA1c level in the blood was revealed (r=-0.79, p
Morphological characteristics of reflux gastritis
Authors: Galiev Sh Z , Amirov N B , Baranova O A 
Published: August 2017

Aim. To study morphological features of gastric mucosa in duodenogastric reflux and the connection of the latter with the level of acidity of gastric contents, presence of H. pylori infection and contractile function of the gallbladder.
Methods. 65 patients were examined: 10 people were included in control group, and in 55 patients reflux gastritis was identified according to gastrointestinal endoscopy. Gastric contents were analyzed for the level of acidity and concentration of bile acids. For all patients histological examination of biopsy material of gastric mucosa at the level of the body and antrum was performed.
Results. Correlation between the acidity level and the concentration of bile acids in gastric contents taken from an empty stomach was found (r=-0.408; p=0.033). In patients with H. pylori pH-level was higher compared to the control group (p=0.047), at the same time the level of bile acids had no significant difference in both groups. Discharge coefficient of the gallbladder in patients with duodenogastric reflux did not differ from the control group. In patients with duodenogastric reflux significant differences from the control group were found in the rate of such morphological signs as chronic inflammatory cell infiltration (p=0.013) and mucosal edema (p=0.032) at the level of the antrum, foveolar hyperplasia at the level of the body of the stomach (p=0.0315).
Conclusion. The degree of duodenogastric reflux has a correlation with acidity of gastric juice; presence or absence of H. pylori does not affect the degree of duodenogastric reflux in primary reflux gastritis; pathomorphological features of duodenogastric reflux are gastric mucosa edema and chronic inflammation at the level of the antrum, foveolar hyperplasia at the level of the body of stomach.
Analysis of mortality in patients with severe community-acquired pneumonia on the background of influenza A (H1N1) pdm09
Authors: Sergeeva I V , Demko I V , Korchagin E E 
Published: August 2017

Aim. To analyze clinical and morphological features of lethal outcomes in influenza A (H1N1) pdm09.
Methods. The article provides an analysis of 21 cases of death from severe complicated influenza A (H1N1) pdm09. A clinical example is presented. The diagnosis of influenza A (H1N1) pdm09 was laboratory-confirmed by polymerase chain reaction in vivo in nasopharyngeal swab samples. The diagnosis of influenza A (H1N1) pdm09 was also confirmed posthumously by polymerase chain reaction with detection of influenza virus antigens in autopsy materials.
Results. The deceased were 25 to 63 years old, were admitted on day 5 to 8 from the beginning of the disease (in average, 6.4±0.6 days), among them 12 (57%) females and 9 (43%) males. The risk factors were overweight and obesity in 18 (85.7%) patients. Lethal outcome occurred as a result of acute respiratory failure and acute respiratory distress syndrome. Morphologically severe total involvement of trachea, lungs and bronchi with congestion of internal organs was detected. Clinical manifestations of acute respiratory failure and acute respiratory distress syndrome were morphologically associated with alveolar damage. In all cases of death diffuse alveolar damage and multiple organ changes were diagnosed.
Conclusion. Severe course of influenza A (H1N1) pdm09, complicated with community-acquired viral and bacterial pneumonia, was associated with the development of infectious-toxic shock; lethal outcome occured as a result of ARF acute respiratory failure and acute respiratory distress syndrome; severe total involvement of trachea, lungs and bronchi with congestion of internal organs was confirmed morphologically.