bluuebunny/crossref_metadata_2025_split huggingface dataset:
Can physicochemical properties of antimicrobials be used to predict their pharmacokinetics during extracorporeal membrane oxygenation? Illustrative data from ovine models
Authors: Shekar Kiran , Roberts Jason A. , Barnett Adrian G. , Diab Sara , Wallis Steven C. , Fung Yoke L. , Fraser John F. 
Published: December 2015

Abstract
Introduction
Ex vivo experiments in extracorporeal membrane oxygenation (ECMO) circuits have identified octanol-water partition coefficient (logP, a marker of lipophilicity) and protein binding (PB) as key drug factors affecting pharmacokinetics (PK) during ECMO. Using ovine models, in this study we investigated whether these drug properties can be used to predict PK alterations of antimicrobial drugs during ECMO.

Methods
Single-dose PK sampling was performed in healthy sheep (HS, n = 7), healthy sheep on ECMO (E24H, n = 7) and sheep with smoke inhalation acute lung injury on ECMO (SE24H, n = 6). The sheep received eight study antimicrobials (ceftriaxone, gentamicin, meropenem, vancomycin, doripenem, ciprofloxacin, fluconazole, caspofungin) that exhibit varying degrees of logP and PB. Plasma drug concentrations were determined using validated chromatographic techniques. PK data obtained from a non-compartmental analysis were used in a linear regression model to predict PK parameters based on logP and PB.

Results
We found statistically significant differences in pH, haemodynamics, fluid balance and plasma proteins between the E24H and SE24H groups (p < 0.001). logP had a strong positive linear relationship with steady-state volume of distribution (Vss) in both the E24H and SE24H groups (p < 0.001) but not in the HS group (p = 0.9) and no relationship with clearance (CL) in all study groups. Although we observed an increase in CL for highly PB drugs in ECMO sheep, PB exhibited a weaker negative linear relationship with both CL (HS, p = 0.01; E24H, p < 0.001; SE24H, p < 0.001) and Vss (HS, p = 0.01; E24H, p = 0.004; SE24H, p =0.05) in the final model.

Conclusions
Lipophilic antimicrobials are likely to have an increased Vss and decreased CL during ECMO. Protein-bound antimicrobial agents are likely to have reductions both in CL and Vss during ECMO. The strong relationship between lipophilicity and Vss seen in both the E24H and SE24H groups indicates circuit sequestration of lipophilic drugs. These findings highlight the importance of drug factors in predicting antimicrobial drug PK during ECMO and should be a consideration when performing and interpreting population PK studies.
PEEP titration during prone positioning for acute respiratory distress syndrome
Authors: Beitler Jeremy R. , Guérin Claude , Ayzac Louis , Mancebo Jordi , Bates Dina M. , Malhotra Atul , Talmor Daniel 
Published: December 2015

AbstractNo major trial evaluating prone positioning for acute respiratory distress syndrome (ARDS) has incorporated a high-positive end-expiratory pressure (high-PEEP) strategy despite complementary physiological rationales. We evaluated generalizability of three recent proning trials to patients receiving a high-PEEP strategy. All trials employed a relatively low-PEEP strategy. After protocol ventilator settings were initiated and the patient was positioned per treatment assignment, post-intervention PEEP was not more than 5 cm H2O in 16.7 % and not more than 10 cm H2O in 66.0 % of patients. Post-intervention PEEP would have been nearly twice the set PEEP had a high-PEEP strategy been employed. Use of either proning or high-PEEP likely improves survival in moderate-severe ARDS; the role for both concomitantly remains unknown.
Fixed point theorems in locally convex spaces and a nonlinear integral equation of mixed type
Authors: Wang Fuli , Zhou Hua 
Published: December 2015

AbstractIn this paper, we provide a new approach for discussing the solvability of a class of operator equations by establishing fixed point theorems in locally convex spaces. Our results are obtained extend some Krasnosel’skii type fixed point theorems. As an application, we investigate the existence and global attractivity of solutions for a general nonlinear integral equation of mixed type of Urysohn and Volterra.
Pediatric asthma and autism—genomic perspectives
Authors: Oh Sunghee , Ji Hong , Barzman Drew , Lin Ping‐I , Hutton John 
Published: December 2015

AbstractHigh‐throughput technologies, ranging from microarrays to NexGen sequencing of RNA and genomic DNA, have opened new avenues for exploration of the pathobiology of human disease. Comparisons of the architecture of the genome, identification of mutated or modified sequences, and pre‐and post‐ transcriptional regulation of gene expression as disease specific biomarkers are revolutionizing our understanding of the causes of disease and are guiding the development of new therapies. There is enormous heterogeneity in types of genomic variation that occur in human disease. Some are inherited, while others are the result of new somatic or germline mutations or errors in chromosomal replication. In this review, we provide examples of changes that occur in the human genome in two of the most common chronic pediatric disorders, autism and asthma. The incidence and economic burden of both of these disorders are increasing worldwide. Genomic variations have the potential to serve as biomarkers for personalization of therapy and prediction of outcomes.
The Michelle Obama influence: an exploration of the first lady’s fashion, style, and impact on women
Authors: Matthews Delisia , Chaney Cassandra , Opiri Jane A. 
Published: December 2015

AbstractGiven keen national interest in the fashion sense of First Lady Michelle Obama, few studies have examined the appeal of the first lady’s style and if her example influences women to modify their styles and shopping behaviors. To address this paucity in the research, the purpose of this study was to explore the impact of Michelle Obama’s apparel choices on women. To address this purpose, ten semi-structured interviews were conducted with women who follow Michelle Obama’s fashion and rated her style as appealing. Qualitative analysis of the interviews revealed three themes: (1) relating through authenticity, (2) permission to defy norms, and (3) brands and the impression of endorsement. Findings reveal that Michelle Obama’s apparel choices make her relatable to everyday women. Participants noted that the first lady’s fashion choices gave them permission to challenge fashion norms for women, and adjust their personal styles. Lastly, several retail brands were thought of more positively by participants, given Michelle Obama’s implied endorsement.
Typification of the Linnaean name Ficus pumila (Moraceae)
Authors: Ferrer-Gallego P. Pablo , Boisset Fernando , Jarvis Charles E. 
Published: December 2015

AbstractThe typification of the name Ficus pumila var. pumila (Moraceae) is discussed. The designation of the corresponding type is based on the consultation of Linnaeus’s original material and the literature cited in the protologue. An illustration from Kaempfer is designated as the lectotype.
A man in crisis: selected short fiction of Joseph Conrad
Authors: Klimková Simona 
Published: December 2015

Abstract
Joseph Conrad devoted twenty years to the writing of short stories. The wide range of subject and setting, spanning from sea stories to domestic tales, managed to constitute Conrad’s reputation as a master story-teller capable of capturing his audience with any theme. While the stories vary in quality, length and themes explored, they all oscillate around the subject of human psyche, with its unpredictability and dark corners portrayed in a rather complex way. The paper seeks to explore the vision of humanity, emerging from Conrad’s short fiction, as well as the literary devices which enable him to capture the essence of human struggle. It focuses primarily on Conrad’s extensive use of figurative language, which contributes to the lyrical quality of his texts, and enables him to express the anguish and disintegration of his characters.
Documentary film as historical narrative
Authors: Urban Marek 
Published: December 2015

Abstract
The submitted study describes the documentary film as a historical narrative that carries within it problems documented by historians such as Paul Veyne and Hayden White. It argues on behalf of the thesis that a documentary film in itself does not classify historical clues according to historical truth but according to a selected purpose (e.g. despite aesthetic conventions or in the case of a narrative film - according to the story). The study refutes the argument of Noël Carroll, who deals with the popularizing documentary film - specifically, connecting scientific “truth” with the tropological character of a documentary film narrative can create at best an approximate picture of a historical event.
Fossil flora of Middle Jurassic Grojec clays (southern Poland). Raciborski’s original material reinvestigated and supplemented. I. Sphenophytes
Authors: Jarzynka Agata , Pacyna Grzegorz 
Published: December 2015

AbstractSphenopsid remains from Grojec clays (Grojec, Poręba, Mirów) collected and described by Raciborski in 1894 are re-examined for the first time and supplemented by Raciborski’s unpublished material housed at the Jagiellonian University (Institute of Botany) and by Stur’s preliminarily described material stored at the Geological Survey of Austria. Three species of Equisetum created by Raciborski (Equisetum renaulti, E. remotum, E. blandum) are now attributed to the common Jurassic species Equisetites lateralis, and the earlierundescribed Equisetites cf. columnaris is recognised. The occurrence of Neocalamites lehmannianus (originally described by Raciborski as Schizoneura hoerensis) has been confirmed from Grojec. The material that Raciborski referred to this species seems to be heterogeneous, and some specimens are now removed to the new proposed species Neocalamites grojecensis Jarzynka et Pacyna sp. nov. The new species is diagnosed by the following features: only a few prominent ribs present on shoot, leaf scars relatively large and ellipsoidal, numerous free leaves, vascular bundles alternate at node. Possibly the new species derives from Neocalamites lehmannianus or at least is closely related to it. Part of the poorly preserved remains can be determined only as Neocalamites sp. Another species created by Raciborski, Phyllotheca (?) leptoderma, is based on poorly preserved type specimens. Some of the unpublished specimens stored at the Jagiellonian University (Institute of Botany) correspond to Raciborski’s description, but considering the poor preservation of the original material and the not very realistic published illustrations of this species, they rather should be regarded as indeterminate cortical fragments of Neocalamites lehmannianus and/or badly preserved external cortical surfaces of the new species Neocalamites grojecensis. Phyllotheca (?) leptoderma should be considered a nomen dubium.
Rectification of invalidly published new names for plants from the late Eocene of North Bohemia
Authors: Kvaček Zlatko 
Published: December 2015

Abstract
Valid publication of new names of fossil plant taxa published since 1 January 1996 requires a diagnosis or description in English, besides other requirements included in the International Code of Nomenclature for algae, fungi, and plants (Melbourne Code) adopted by the Eighteenth International Botanical Congress, Melbourne, Australia, July 2011 (McNeill et al. 2012). In order to validate names published from the late Eocene flora of the Staré Sedlo Formation, North Bohemia, diagnosed only in German (Knobloch et al. 1996), English translations are provided, including references to the type material and further relevant information.
On the polyhedrality of global Okounkov bodies
Authors: Schmitz David , Seppänen Henrik 
Published: December 2015

Abstract
We prove that the existence of a finite Minkowski basis for Okounkov bodies on a smooth projective variety with respect to an admissible flag implies the rational polyhedrality of the global Okounkov body. As an application of this general result, we deduce that the global Okounkov body of a surface with finitely generated pseudo-effective cone with respect to a general flag is rational polyhedral. We give an alternative proof for this fact which recovers the generators more explicitly. We also prove the rational polyhedrality of global Okounkov bodies in the case of certain homogeneous 3-folds using inductive methods.
A late Albian ammonite assemblage from the mid- Cretaceous succession at Annopol, Poland
Authors: Kennedy William J. , Machalski Marcin 
Published: December 2015

Abstract
A previously unrecorded ammonite assemblage, comprising Lepthoplites sp., Callihoplites tetragonus (Seeley, 1865), C. cf. tetragonus, Arrhaphoceras cf. substuderi Spath, 1923, Cantabrigites sp., Stoliczkaiella (Stoliczkaiella) sp., Hamites cf. duplicatus Pictet and Campiche, 1861, H. cf. subvirgulatus Spath, 1941, and H. cf. venetzianus Pictet, 1847, is described from the mid-Cretaceous condensed succession at Annopol, Poland. These specimens are preserved as pale phosphates or sandstone moulds in a bed of reworked phosphatic nodules near the top of the Albian. This assemblage has many species in common with the late late Albian faunas from condensed deposits of England, Switzerland, and France. The presence of Callihoplites tetragonus indicates the lowermost upper upper Albian Mortoniceras fallax Zone. The ammonites studied are the youngest elements in the phosphate bed, which also contains taxa as old as the middle Albian Hoplites dentatus Zone. This bed originated through condensation and reworking of nodules and fossils in a period of low net sedimentation rate, being probably a reflection of a sea-level drop at the boundary between the classic ammonite zones of Mortoniceras inflatum and Stoliczkaiella dispar.
The human iron exporter ferroportin. Insight into the transport mechanism by molecular modeling
Authors: Tortosa Valentina , di Patti Maria Carmela Bonaccorsi , Musci Giovanni , Polticelli Fabio 
Published: December 2015

Abstract
Ferroportin, a membrane protein belonging to the major facilitator superfamily of transporters, is the only vertebrate iron exporter known so far. Several ferroportin mutations lead to the so-called ferroportin disease or type 4 hemochromatosis, characterized by two distinct iron accumulation phenotypes depending on whether the mutation affects the activity of the protein or its degradation pathway. Through extensive molecular modeling analyses using the structure of all known major facilitator superfamily members as templates, multiple structural models of ferroportin in the three mechanistically relevant conformations (inward open, occluded, and outward open) have been obtained. The best models, selected on the ground of experimental data available on wild-type and mutant ferroportion, provide for the first time a prediction at the atomic level of the dynamics of the transporter. Based on these results, a possible mechanism for iron export is proposed.
Why Basic Income’s Emancipatory Value Exceeds Its Monetary Value
Authors: Standing Guy 
Published: December 2015

AbstractThis article argues that the emancipatory value of a basic income is greater than its monetary value, drawing on the results of a large-scale basic income scheme conducted in the Indian State of Madhya Pradesh between 2010 and 2013. The scheme was evaluated by comparing households in villages where everyone received a small cash payment each month with households in similar villages where no one did. The evaluation results showed much stronger than anticipated benefits of a very modest basic income, equivalent to about a third of subsistence. It is argued here that this arises because cash payments alleviate the contrived scarcity of money itself, a cause of chronic indebtedness and impoverishment. Using data and illustrative case studies on debt, savings and financial inclusion, the article demonstrates how a basic income improves economic security beyond its monetary value, which can be termed its emancipatory value. It further concludes that a basic income would have an emancipatory effect for the growing precariat around the world.
A multi-level method of support for management of product flow through supply chains
Authors: Magiera M. 
Published: December 2015

Abstract
The paper presents a three-level method used to support the management of product flow through supply chain links (e.g. production lines) and between these links: suppliers and recipients of products of various types.The supply chain includes both producers of components (suppliers) and recipients of these components, which are used for the production of complex goods. The method is dedicated to the development of schedules of product flows through particular production plants (links in supply chains) and between individual plants. Each module of the developed system refers to a separate production plant. The organization of product flow through production lines covers different types of production routes and different configurations of production systems. At the first level of the method, preliminary production schedules are developed for each plant within the supply chain. The second level of the method is dedicated to the development of delivery schedules of components and semi-finished products to these plants. The determined delivery times of components to the individual production plants constitute data for the third level of the method. At this lowest level, detailed schedules of product flow through production lines with the producers of complex goods are developed. Linear mathematical models have been built for each level of the method. In the developed method, optimization take place in the developed method in the scale of the entire supply chain (cost reduction), as well as in the scale of its links (production lines for which manufacturing schedules are built with various criteria taken into consideration). The computational experiments used for verification of the method have been included.
Influence of fracture-matrix interaction on thermal front movement in fractured reservoir
Authors: Siemek J. , Stopa J. 
Published: December 2015

Abstract
Commercial exploitation of geothermal resources requires the disposal of large volumes of cooled brine in an environmentally acceptable way. Reinjection of cooled (i.e. spent) geothermal water has become a standard reservoir management strategy. Since injected fluids are typically much colder than the reservoir rock, this strategy results in the cooling of the region around the injection wells. Injected cool water may not have sufficient residence time in the reservoir to receive enough heat from surrounding hotter rock, resulting in temperature decrease at producing wells. Usually, the energy transport in geothermal reservoirs is calculated by use of sophisticated numerical simulators. In this paper we present analytical solution of simplified model of mass and heat transfer in fractured porous medium in one dimension, assuming constant rock temperature and neglecting small-scale effect connected with dispersion and heat conduction. The solution presented in this paper is applicable if thermal capacity of rock is high but the specific area is not sufficient for instant thermal equilibrium. This approach allows for better understanding the relation between fluid movement along the fractures and heat transfer between the rock matrix and fluid. Simple numerical experiments reported in the paper have shown the importance of specific surface area of naturally fractured rock, which influences the rate of exchange of heat between the fractures and the rock matrix.
A robust predictive actuator fault-tolerant control scheme for Takagi-Sugeno fuzzy systems
Authors: Witczak P. , Witczak M. , Korbicz J. , Aubrun Ch. 
Published: December 2015

Abstract
The paper deals with the problem of robust predictive fault-tolerant control for nonlinear discrete-time systems described by the Takagi-Sugeno models. The proposed approach is based on a triple stage procedure, i.e. it starts from fault estimation while the fault is compensated with a robust controller. The robust controller is designed without taking into account the input constraints related with the actuator saturation that may change due to its faulty behaviour. Thus, to check the compensation feasibility, the robust invariant set is developed, which takes into account the input constraints. If the current state does not belong to the robust invariant set, then suitable predictive control actions are performed in order to enhance the invariant set. This appealing phenomenon makes it possible to enlarge the domain of attraction, which makes the proposed approach an efficient solution for the fault-tolerant control. The final part of the paper shows an illustrative example regarding the application of the proposed approach to the twin-rotor system.
Assessment of Steel Reinforcement Corrosion State by Parameters of Potentiodynamic Diagrams
Authors: Krajči Ľudovít , Jerga Ján 
Published: December 2015

Abstract
The environment of the steel reinforcement has a significant impact on the durability and service life of a concrete structure. It is not only the presence of aggressive substances from the environment, but also the own composition of concrete mixture. The use of new types of cements, additives and admixtures must be preceded by verification, if they themselves shall not initiate the corrosion. There is a need for closer physical expression of the parameters of the potentiodynamic diagrams allowing reliable assessment of the influence of the surrounding environment on electrochemical behaviour of reinforcement. The analysis of zero retardation limits of potentiodynamic curves is presented.
Deformation Parameters and Fatigue of the Recycled Asphalt Mixtures
Authors: Šrámek Juraj 
Published: December 2015

Abstract
The deformational properties of asphalt mixtures measured by dynamic methods and fatigue allow a design the road to suit the expected traffic load. Quality of mixtures is also expressed by the resistance to permanent deformation. Complex modulus of stiffness and fatigue can reliably characterize the proposed mixture of asphalt pavement. The complex modulus (E*) measurement of asphalt mixtures are carried out in laboratory of Department of Construction Management at University of Žilina by two-point bending test method on trapezoid-shaped samples. Today, the fatigue is verified on trapezoid-shaped samples and is assessed by proportional strain at 1 million cycles (ε6). The test equipment and software is used to evaluate fatigue and deformation characteristics.
Stiffness of Carpentry Connections – Numerical Modelling vs. Experimental Test
Authors: Kekeliak Miloš , Gocál Jozef , Vičan Josef 
Published: December 2015

Abstract
In this paper, numerical modelling of the traditional carpentry connection with mortise and tenon is presented. Numerical modelling is focused on its stiffness and the results are compared to results of experimental tests carried out by (Feio, 2005) [6]. To consider soft behaviour of wood in carpentry connections, which are related to its surface roughness and geometrical accuracy of the contact surfaces, the characteristics of the normal contact stiffness, determined experimentally, are introduced in the numerical model. Parametric study by means of numerical modelling with regard to the sensitivity of connection stiffness to contact stiffness is presented. Based on the study results, in conclusion there are presented relevant differences between the results of numerical modelling and experimental tests (Feio, 2005) [6].