bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional hemodynamic testing in pregnancy: recommendations of the International Working Group on Maternal Hemodynamics
Authors: Meah V. L. , Backx K. , Davenport M. H. ,   the International Working Group on Maternal Hemodynamics
Published: August 2017

ABSTRACTIn the general population, functional hemodynamic testing, such as that during submaximal aerobic exercise and isometric handgrip, and the cold pressor test, has long been utilized to unmask abnormalities in cardiovascular function. During pregnancy, functional hemodynamic testing places additional demands on an already stressed maternal cardiovascular system. Dysfunctional responses to such tests in early pregnancy may predict the development of hypertensive disorders that develop later in gestation. For each of the above functional hemodynamic tests, these recommendations provide a description of the test, test protocol and equipment required, and an overview of the current understanding of clinical application during pregnancy. Copyright © 2017 ISUOG. Published by John Wiley & Sons Ltd.
The association between metacognitive abilities and outcome measures among people with schizophrenia: A meta-analysis
Authors: Arnon-Ribenfeld N. , Hasson-Ohayon I. , Lavidor M. , Atzil-Slonim D. , Lysaker P.H. 
Published: August 2017

AbstractBackground:Deficits in metacognition are one of the major causes of the difficulties experienced by individuals with schizophrenia. Studies have linked these deficits to symptom exacerbation and deterioration in psychosocial functioning. The aim of the present meta-analysis was to examine the extensive existing literature regarding metacognitive deficits among persons with schizophrenia; a further aim was to assess the extent to which metacognitive abilities are linked to outcome measures of symptoms and psychosocial functioning.Method:We conducted a systematic literature search of studies examining the relationship between metacognitive abilities and outcome measures among people with schizophrenia. We then analyzed the data using a random-effects meta-analytic model with Cohen's d standardized mean effect size.Results:Heterogeneity analyses (k = 32, Cohen's d = −.12, 95% CI.−1.92 to 1.7) produced a significant Q-statistic (Q = 456.89) and a high amount of heterogeneity, as indicated by the I2 statistic (93.04%), suggesting that moderator analyses were appropriate. As hypothesized, measure type moderated the metacognitive deficit with homogenous effect for psychosocial functioning measures (Q = 9.81, I2 = 19.47%, d = .94. 95% CI .58 to 1.2) and symptoms (Q = 19.87, I2 = 0%, d = −1.07, 95% CI −1.18 to −.75). Further analysis found homogenous effects for MAS-A subscales as well as PANSS factors of symptoms.Conclusion:Our meta-analysis results illustrated a significant association between metacognitive deficits and both symptomatic and psychosocial functioning measures. These links suggest that the associations between metacognitive abilities and symptomatic outcomes are different from those between metacognitive abilities and psychosocial functioning measures. Intriguing hypotheses are raised regarding the role that metacognitive abilities play in both symptoms and psychosocial functioning measures of people diagnosed with schizophrenia spectrum disorders.
Asymmetries abound: Ideological differences in emotion, partisanship, motivated reasoning, social network structure, and political trust
Authors: Jost John T. 
Published: August 2017

AbstractThis article is a response to Rao (2017), Krishna and Sokolova (2017), and Oyserman and Schwarz (2017), all of whom provided extremely thoughtful commentaries on a target article in which I summarized several lines of research in political psychology on liberal‐conservative differences in personality, cognition, motivation, values, and neurological structures and functions (Jost, 2017a). I begin by correcting a possible misconception, namely that the theory of political ideology as motivated social cognition cannot explain dynamic shifts in ideological affinities; on the contrary, we have demonstrated that “top‐down” situational—as well as “bottom‐up” dispositional—processes work in conjunction to produce ideological outcomes, and this is why tailored forms of political persuasion can be highly effective in producing change. Next I describe additional evidence (including previously unpublished evidence) bearing on ideological symmetries and asymmetries with respect to emotion, partisanship, social identification, motivated reasoning, social network structure, and political trust. I end by asking consumer psychologists for their continued collaboration in addressing profound challenges associated with understanding and reconciling sources of ideological divergence—not only for the sake of research in behavioral science but also for the smooth functioning of democratic society.
Midwives’ Professional Competencies for Preventing Maternal Mortality in Disasters: A Cross-Sectional Study in Iran
Authors: Taghizadeh Ziba , Khoshnam Rad Mahsa , Kazemnejad Anoshirvan 
Published: August 2017

AbstractObjectiveMaternal mortality may increase after a disaster. Because midwives are at the frontline of offering reproductive health care services in disasters, they should be competent.MethodsThis was a cross-sectional, descriptive study carried out in 2015 in Tehran. The sample consisted of 361 midwives selected by use of a cluster random sampling method. Data were collected by using a questionnaire on professional competency for preventing maternal mortality in disasters.ResultsThe midwives’ mean professional competency score was 177.74±31, which was an average level of professional competency. The level of knowledge and skills of the midwives was reported as inadequate for most items, particularly for the items of “managing mothers affected by chronic diseases,” “physical trauma,” “recognizing patients who needed to be referred,” and “stabilizing mothers when referring them.” Statistically significant relationships were observed between the midwives’ competencies and age (P=0.001), work experience (P=0.054), educational level (P= 0.043), previous experience in a disaster (P=0.014), and workplace (P=0.006). These data were drawn by using Spearman’s correlation, t-test, and ANOVA, respectively.ConclusionsGiven the average scores for midwives’ professional competency in disasters and the inadequacy of prior training courses, extra educational programs for midwives are recommended. (Disaster Med Public Health Preparedness. 2018; 12: 305–311)
Exact Lagrangian submanifolds, Lagrangian spectral invariants and Aubry–Mather theory
Authors: AMORIM LINO , OH YONG–GEUN , OLIVEIRA DOS SANTOS JOANA 
Published: August 2017

AbstractWe construct graph selectors for compact exact Lagrangians in the cotangent bundle of an orientable, closed manifold. The construction combines Lagrangian spectral invariants, developed by Oh, and results, by Abouzaid, about the Fukaya category of a cotangent bundle. We also introduce the notion of Lipschitz-exact Lagrangians and prove that these admit an appropriate generalisation of graph selector. We then, following Bernard–Oliveira dos Santos, use these results to give a new characterisation of the Aubry and Mañé sets of a Tonelli Hamiltonian and to generalise a result of Arnaud on Lagrangians invariant under the flow of such Hamiltonians.
MESOAMERICAN FLAT CURVED STICKS: INNOVATIVE “TOLTEC” SHORT SWORD, FENDING STICK, OR OTHER PURPOSE?
Authors: Geib Phil R. 
Published: August 2017

AbstractFlat and curved sticks with longitudinal facial grooves were dredged from the Sacred Cenote at Chichen Itza in the early 1900s. They are similar to specimens recovered from the North American Southwest, where a suggested function was for defense against atlatl darts. By accepting this interpretation, Mesoamerican archaeologists identified such artifacts as fending sticks. Hassig (1992:112–114, 126–127, 2001:810–811) disputes this role, arguing that the sticks were specialized short swords for close fighting. This sword interpretation is not supported by my analysis of the Chichen Itza artifacts or the mural evidence at that site. Defense against atlatl darts is possible but unlikely to have occurred in warfare and, in any case, Maya/Toltec warriors carried shields to protect themselves against darts and other weapons. Fending darts in ritual fights such as an atlatl duel is a plausible scenario, perhaps to prove warrior mettle or as a gladiatorial blood sport. Another possible use is for subduing captives after military victory: a throwing stick to disable humans for later sacrifice.
Marriage Reform and the Constitution of the United Reformed Church
Authors: Pearce Augur 
Published: August 2017

Recent reforms to English and Scots marriage law faced the United Reformed Church (URC) with two challenges. Its hybrid structure of church government, entwining Congregational and Presbyterian strands, complicated application of the statutory criterion ‘persons recognised by [the membership] as competent for the purpose of giving consent’. Precedent from earlier decisions on human sexuality explains the ultimate identification of the local church meeting as the competent council of the URC in England, and why the ‘enabling resolution’ passed regarding civil partnership formation was not repeated. The very different focus of Scots marriage law posed different questions, less focused on buildings or the churches using them and allowing willing celebrants to be nominated by the synod, as for opposite-sex marriage.Advisers differed on whether the denomination possessed any binding doctrine of marriage which would obstruct implementation of the amended law. The General Assembly decision on polity and how it was reached suggest an implicit ruling in the negative. This article defends that outcome, considering the doctrinal foundation of the URC in the light of concessions made at the formative union. Marriage appears as a topic on which no denominational doctrine exists, letting all councils reach theological conclusions necessary to practical decisions within their remit.
Syntone chemistry and prebiotic stage in life evolution 1. Aziridinone, a key compound in formation of the first proteinogenic amino acids and polypeptides
Authors: Surpateanu Gheorghe 
Published: August 2017

AbstractIn this paper is proposed a new theory concerning the formation of the first proteinogenic amino acids and their corresponding polypeptides starting of three syntones: methylene, nitrene and carbon monoxide. First, at low temperature in nitrogen, these three syntones form aziridinone, an asimetric compound in special conditions. Next, by a series of radical chain, izomerization, cyclization, elimination and polymerization reactions, apparently without a well defined transition states are formed a series of precursor syntones. Finally, these more structured syntones at the contract with the components of primary atmosphere, especially with water, ammonia, hydrogen sulphide, even with carbon dioxide and methane offer the first proteinogenic amino acids and their first corresponding polypeptides. As a very important aspect, the aziridinone cycle furnish the backbone of proteinogenic amino acids. The formation of each proteinogenic amino acid moiety also as its participation to construction of polypeptide structures were estimated by two parameters: (1) the complex structural factor,Feand (2) the participation coefficient,Cprespectively. Dominantly, the quantitative results given in this paper were acquired by structural, thermodynamical and reactivity studies using DGauss with the B88-LYP GGA energy functional with high integral accuracy. Finally, an experimental assembly for obtention of amino acids and polypeptides is proposed. Brief, the three initial syntones: CH2, NH and CO, in nitrogen form aziridinone. That, in reactions with the same three syntones form, the more structured syntone precursors of proteinogenic amino acids and polypeptides. At the contact with primary atmosphere components are formed the first proteinogenic amino acids and polypeptides. The first polypeptides appear from polypeptide precursors and not from proteinogenic amino acids.
Economic and productivity incentives to produce organically in Brazil: Evidence from strawberry production in the Federal District
Authors: Resende Filho M. A. , Andow D. A. , Carneiro R. G. , Lorena D. R. , Sujii E. R. , Alves R. T. 
Published: August 2017

AbstractBrazil has the largest market for organic products in Latin America, but only 1.04% of its agricultural land is utilized for organic production (OP). We compared organic and conventional production (CP) in economic and productivity terms using data from a randomized survey of 86 organic and conventional strawberry growers (response rate 85.2%) in Brazlândia, Federal District, Brazil. Probit model selection estimates showed that the use of technical assistance from rural extension and producer gender had no effect, but growers with greater age, higher indebtedness, smaller strawberry production area, more education and less experience on growing strawberries were more likely to produce organically. For growers with more than 5.6 years of education and less than 13.54 years of experience, more education and experience make them less likely to produce strawberry organically. Thus, we expect growers’ probabilities of conversion for strawberry OP will remain about the same over time in the study area. The average treatment effect for the treated (ATT) was estimated using nearest neighbor/propensity score matching and endogenous switching regression (ESR). These showed that producing strawberry organically had no effect on productivity or total cost per box, but increased revenue and profit per box, probably as a result of the price premium for organic strawberries. As only 4.8% of farmers had converted to organic production, conversion costs and non-economic factors, such as psychological factors and social capital, may be barriers to conversion.
Common microRNA–mRNA interactions exist among distinct porcine iPSC lines independent of their metastable pluripotent states
Authors: Zhang Shiqiang , Xie Youlong , Cao Hongxia , Wang Huayan 
Published: August 2017

AbstractPrevious evidences have proved that porcine-induced pluripotent stem cells (piPSCs) could be induced to distinctive metastable pluripotent states. This raises the issue of whether there is a common transcriptomic profile existing among the piPSC lines at distinctive state. In this study, we performed conjoint analysis of small RNA-seq and mRNA-seq for three piPSC lines which represent LIF dependence, FGF2 dependence and LFB2i dependence, respectively. Interestingly, we found there are 16 common microRNAs which potentially target 13 common mRNAs among the three piPSC lines. Dual-luciferase reporter assay validated that miR-370, one of the 16 common microRNAs, could directly target the 3′UTR of LIN28A. When the differentiation occurred, miR-370 could be activated in piPSCs and switched off the expression of LIN28A. Ectopic expression of miR-370 in piPSCs could reduce LIN28A expression, decrease the alkaline phosphatase activity, slow down the proliferation, and further cause the downregulation of downstream pluripotent genes (OCT4, SOX2, NANOG, SALL4 and ESRRB) and upregulation of differentiation relevant genes (SOX9, JARID2 and JMJD4). Moreover, these phenotypes caused by miR-370 could be rescued by overexpressing LIN28A. Collectively, our findings suggest that a set of common miRNA–mRNA interactions exist among the distinct piPSC lines, which orchestrate the self-renewal and differentiation of piPSCs independent of their metastable pluripotent states.
Alkaline earth metal vanadates as sodium-ion battery anodes
Authors: Xu Xiaoming , Niu Chaojiang , Duan Manyi , Wang Xuanpeng , Huang Lei , Wang Junhui , Pu Liting , Ren Wenhao , Shi Changwei , Meng Jiasheng , Song Bo , Mai Liqiang 
Published: August 2017

AbstractThe abundance of sodium resources indicates the potential of sodium-ion batteries as emerging energy storage devices. However, the practical application of sodium-ion batteries is hindered by the limited electrochemical performance of electrode materials, especially at the anode side. Here, we identify alkaline earth metal vanadates as promising anodes for sodium-ion batteries. The prepared calcium vanadate nanowires possess intrinsically high electronic conductivity (> 100 S cm−1), small volume change (< 10%), and a self-preserving effect, which results in a superior cycling and rate performance and an applicable reversible capacity (> 300 mAh g−1), with an average voltage of ∼1.0 V. The specific sodium-storage mechanism, beyond the conventional intercalation or conversion reaction, is demonstrated through in situ and ex situ characterizations and theoretical calculations. This work explores alkaline earth metal vanadates for sodium-ion battery anodes and may open a direction for energy storage.
Ultrafast isomerization in acetylene dication after carbon K-shell ionization
Authors: Li Zheng , Inhester Ludger , Liekhus-Schmaltz Chelsea , Curchod Basile F. E. , Snyder James W. , Medvedev Nikita , Cryan James , Osipov Timur , Pabst Stefan , Vendrell Oriol , Bucksbaum Phil , Martinez Todd J. 
Published: August 2017

AbstractUltrafast proton migration and isomerization are key processes for acetylene and its ions. However, the mechanism for ultrafast isomerization of acetylene [HCCH]2+ to vinylidene [H2CC]2+ dication remains nebulous. Theoretical studies show a large potential barrier ( > 2 eV) for isomerization on low-lying dicationic states, implying picosecond or longer isomerization timescales. However, a recent experiment at a femtosecond X-ray free-electron laser suggests sub-100 fs isomerization. Here we address this contradiction with a complete theoretical study of the dynamics of acetylene dication produced by Auger decay after X-ray photoionization of the carbon atom K shell. We find no sub-100 fs isomerization, while reproducing the salient features of the time-resolved Coulomb imaging experiment. This work resolves the seeming contradiction between experiment and theory and also calls for careful interpretation of structural information from the widely applied Coulomb momentum imaging method.
Towards designer organelles by subverting the peroxisomal import pathway
Authors: Cross Laura L. , Paudyal Rupesh , Kamisugi Yasuko , Berry Alan , Cuming Andrew C. , Baker Alison , Warriner Stuart L. 
Published: August 2017

AbstractThe development of ‘designer’ organelles could be a key strategy to enable foreign pathways to be efficiently controlled within eukaryotic biotechnology. A fundamental component of any such system will be the implementation of a bespoke protein import pathway that can selectively deliver constituent proteins to the new compartment in the presence of existing endogenous trafficking systems. Here we show that the protein–protein interactions that control the peroxisomal protein import pathway can be manipulated to create a pair of interacting partners that still support protein import in moss cells, but are orthogonal to the naturally occurring pathways. In addition to providing a valuable experimental tool to give new insights into peroxisomal protein import, the variant receptor-signal sequence pair forms the basis of a system in which normal peroxisomal function is downregulated and replaced with an alternative pathway, an essential first step in the creation of a designer organelle.
Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients
Authors: Zhang Ya-Kun , Qu Yuan-Yuan , Lin Yan , Wu Xiao-Hui , Chen Hou-Zao , Wang Xu , Zhou Kai-Qiang , Wei Yun , Guo Fushen , Yao Cui-Fang , He Xia-Di , Liu Li-Xia , Yang Chen , Guan Zong-Yuan , Wang Shi-Dong , Zhao Jianyuan , Liu De-Pei , Zhao Shi-Min , Xu Wei 
Published: August 2017

AbstractThe oncogenic mechanisms of overnutrition, a confirmed independent cancer risk factor, remain poorly understood. Herein, we report that enoyl-CoA hydratase-1 (ECHS1), the enzyme involved in the oxidation of fatty acids (FAs) and branched-chain amino acids (BCAAs), senses nutrients and promotes mTOR activation and apoptotic resistance. Nutrients-promoted acetylation of lys101 of ECHS1 impedes ECHS1 activity by impairing enoyl-CoA binding, promoting ECHS1 degradation and blocking its mitochondrial translocation through inducing ubiquitination. As a result, nutrients induce the accumulation of BCAAs and FAs that activate mTOR signaling and stimulate apoptosis, respectively. The latter was overcome by selection of BCL-2 overexpressing cells under overnutrition conditions. The oncogenic effects of nutrients were reversed by SIRT3, which deacetylates lys101 acetylation. Severely decreased ECHS1, accumulation of BCAAs and FAs, activation of mTOR and overexpression of BCL-2 were observed in cancer tissues from metabolic organs. Our results identified ECHS1, a nutrients-sensing protein that transforms nutrient signals into oncogenic signals.
APOBEC3A is an oral cancer prognostic biomarker in Taiwanese carriers of an APOBEC deletion polymorphism
Authors: Chen Ting-Wen , Lee Chi-Ching , Liu Hsuan , Wu Chi-Sheng , Pickering Curtis R. , Huang Po-Jung , Wang Jing , Chang Ian Yi-Feng , Yeh Yuan-Ming , Chen Chih-De , Li Hsin-Pai , Luo Ji-Dung , Tan Bertrand Chin-Ming , Chan Timothy En Haw , Hsueh Chuen , Chu Lichieh Julie , Chen Yi-Ting , Zhang Bing , Yang Chia-Yu , Wu Chih-Ching , Hsu Chia-Wei , See Lai-Chu , Tang Petrus , Yu Jau-Song , Liao Wei-Chao , Chiang Wei-Fan , Rodriguez Henry , Myers Jeffrey N. , Chang Kai-Ping , Chang Yu-Sun 
Published: August 2017

AbstractOral squamous cell carcinoma is a prominent cancer worldwide, particularly in Taiwan. By integrating omics analyses in 50 matched samples, we uncover in Taiwanese patients a predominant mutation signature associated with cytidine deaminase APOBEC, which correlates with the upregulation of APOBEC3A expression in the APOBEC3 gene cluster at 22q13. APOBEC3A expression is significantly higher in tumors carrying APOBEC3B-deletion allele(s). High-level APOBEC3A expression is associated with better overall survival, especially among patients carrying APOBEC3B-deletion alleles, as examined in a second cohort (n = 188; p = 0.004). The frequency of APOBEC3B-deletion alleles is ~50% in 143 genotyped oral squamous cell carcinoma -Taiwan samples (27A3B−/−:89A3B+/−:27A3B+/+), compared to the 5.8% found in 314 OSCC-TCGA samples. We thus report a frequent APOBEC mutational profile, which relates to a APOBEC3B-deletion germline polymorphism in Taiwanese oral squamous cell carcinoma that impacts expression of APOBEC3A, and is shown to be of clinical prognostic relevance. Our finding might be recapitulated by genomic studies in other cancer types.