bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome-wide association study of response to cognitive–behavioural therapy in children with anxiety disorders
Authors: Coleman Jonathan R. I. , Lester Kathryn J. , Keers Robert , Roberts Susanna , Curtis Charles , Arendt Kristian , Bögels Susan , Cooper Peter , Creswell Cathy , Dalgleish Tim , Hartman Catharina A. , Heiervang Einar R. , Hötzel Katrin , Hudson Jennifer L. , In-Albon Tina , Lavallee Kristen , Lyneham Heidi J. , Marin Carla E. , Meiser-Stedman Richard , Morris Talia , Nauta Maaike H. , Rapee Ronald M. , Schneider Silvia , Schneider Sophie C. , Silverman Wendy K. , Thastum Mikael , Thirlwall Kerstin , Waite Polly , Wergeland Gro Janne , Breen Gerome , Eley Thalia C. 
Published: March 2016

BackgroundAnxiety disorders are common, and cognitive–behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent.AimsTo perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980).MethodPresence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up.ResultsNo variants passed a genome-wide significance threshold (P=5×10–8) in either analysis. Four variants met criteria for suggestive significance (P<5×10–6) in association with response post-treatment, and three variants in the 6-month follow-up analysis.ConclusionsThis is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.
ATR-101, a Selective and Potent Inhibitor of Acyl-CoA Acyltransferase 1, Induces Apoptosis in H295R Adrenocortical Cells and in the Adrenal Cortex of Dogs
Authors: LaPensee Christopher R. , Mann Jacqueline E. , Rainey William E. , Crudo Valentina , Hunt Stephen W. , Hammer Gary D. 
Published: March 2016

AbstractATR-101 is a novel, oral drug candidate currently in development for the treatment of adrenocortical cancer. ATR-101 is a selective and potent inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1), an enzyme located in the endoplasmic reticulum (ER) membrane that catalyzes esterification of intracellular free cholesterol (FC). We aimed to identify mechanisms by which ATR-101 induces adrenocortical cell death. In H295R human adrenocortical carcinoma cells, ATR-101 decreases the formation of cholesteryl esters and increases FC levels, demonstrating potent inhibition of ACAT1 activity. Caspase-3/7 levels and terminal deoxynucleotidyl transferase 2′-deoxyuridine 5′-triphosphate nick end labeled-positive cells are increased by ATR-101 treatment, indicating activation of apoptosis. Exogenous cholesterol markedly potentiates the activity of ATR-101, suggesting that excess FC that cannot be adequately esterified increases caspase-3/7 activation and subsequent cell death. Inhibition of calcium release from the ER or the subsequent uptake of calcium by mitochondria reverses apoptosis induced by ATR-101. ATR-101 also activates multiple components of the unfolded protein response, an indicator of ER stress. Targeted knockdown of ACAT1 in an adrenocortical cell line mimicked the effects of ATR-101, suggesting that ACAT1 mediates the cytotoxic effects of ATR-101. Finally, in vivo treatment of dogs with ATR-101 decreased adrenocortical steroid production and induced cellular apoptosis that was restricted to the adrenal cortex. Together, these studies demonstrate that inhibition of ACAT1 by ATR-101 increases FC, resulting in dysregulation of ER calcium stores that result in ER stress, the unfolded protein response, and ultimately apoptosis.
Perfil sociodemográfico y caracterización de las empresas de la mujer emprendedora en España. Fortalezas y debilidades
Authors: Olaz Capitán Ángel José , Ortiz García Pilar 
Published: March 2016

En las últimas décadas la investigación sobre el emprendimiento está adquiriendo un importante protagonismo como resultado de los cambios experimentados en esta forma de actividad empresarial. La presencia de la mujer en este ámbito de actuación es cada vez más evidente como reacción ante las mayores dificultades de acceso al empleo en un contexto de crisis y no tanto a la visión romántica de una «idea luminosa» que se materializa por generación espontánea. En este contexto el impulso a la iniciativa emprendedora que las mujeres están desarrollando adquiere una especial singularidad.Tomando como principal fuente de referencia la explotación de los datos del proyecto GEM 2012 —última actualización disponible—, esta comunicación profundizará en el estudio del perfil sociodemográfico de la mujer emprendedora en España en el intento por caracterizar las singularidades de las empresas en las que éstas desarrollan su actividad.La comparativa por géneros presenta importantes elementos de análisis atendiendo a variables tales como: expectativas de crecimiento del empleo, razones de abandono de la empresa, motivaciones de emprendimiento por necesidad, orientación internacional de la empresa y otros tantos elementos que se estudiarán.A través de estas primeras conclusiones, el proposito de esta comunicación es reflexionar sobre las características que hacen de la mujer una potencial emprendedora y, por consiguiente, anticipar medidas que contribuyan a su mejor visibilización y puesta en valor como elemento clave en el desarrollo laboral, social y económico de nuestra sociedad.
Discriminación laboral por razón de género
Authors: Ordóñez Yraolagoitia Leyre 
Published: March 2016

La discriminación en el trabajo por razón de sexo, es algo que, desgraciadamente, todos conocemos. Es innegable que este fenómeno se sigue produciendo, tanto en nuestro país como en nuestra comunidad autónoma, pero aunque conozcamos el problema que esto supone, ¿nos paramos a cambiarlo? Es una actitud que mucha gente tiene arraigada y que probablemente le salga de una manera inconsciente, ya que la discriminación en el trabajo es la última pieza de otra serie de actitudes machistas. Hay diferentes maneras de discriminación, y aquí se podrán observar cuáles son y de qué manera afectan a las mujeres de nuestro entorno.Por último, los datos también muestran que esta es una situación que conviene cambiar tanto a mujeres como a hombres. Aunque esta discriminación hacia la mujer sea real, los hombres también están sufriendo un cierto castigo por tantos años de desigualdad, como por ejemplo en la interpretación de las leyes, el sentimiento de culpa que pueda tener uno consigo mismo… Por lo tanto, es una realidad y un problema con muchos matices, pero que hay que empezar a solucionar desde la raíz.
An investigation of the motivation, collaboration and satisfaction levels related to teamwork of Turkish football referees
Authors: Satman Mehmet Cem 
Published: March 2016

During the past 10 to 15 years refereeing elite football matches has become much more demanding in terms of the physical and mental preparation referees have to undertake. This is because the game is now faster and the players fitter than ever before. So much so that referees have come to rely more and more on the other officials to ensure correct decisions. Thus, they have become more like a team leader rather than the sole arbiter they were for so long; cooperation is now essential for successful football refereeing. This study examines the attitudes of football referees towards teamwork, their levels of motivation and their job satisfaction according to their level of refereeing, age and experience. 285 referees and assistant referees, all of whom referee in professional leagues, took part in this study. From the results it was concluded that younger referees are likely to adopt a more 'managed', solo approach while older referees are more likely to adopt a more 'collaborative' approach. These findings provide a baseline for developing young referees' perception of and attitude towards teamwork and highlight the need for improvement.
Pengaruh Inovasi Kelembagaan Pada Pengembangan Klaster Batik Laweyan Kota Surakarta
Authors: Wulandari Ery Dyah 
Published: March 2016

<p class="Abstract">Klaster Batik Laweyan adalah salah satu klaster yang memiliki pertumbuhan signifikan yang ditunjukkan melalui inovasi kelembagaan di dalamnya. Hal ini dibuktikan dari kondisi perdagangan sebelum Laweyan dikembangkan serta adanya Forum Pengembangan Kampoeng Batik Laweyan yang mewadahi pengembangan klaster tersebut. Penelitian ini memunculkan pertanyaan “Bagaimana inovasi kelembagaan mempengaruhi pengembangan Klaster Batik Laweyan?”. Untuk menjawab pertanyaan penelitian tersebut, pendekatan penelitian yang digunakan adalah kualitatif dengan metode deskriptif kualitatif. Metode ini dipilih karena dapat mengkaji informasi yang dibutuhkan untuk menjawab sasaran penelitian secara mendalam. Data diperoleh melalui wawancara dan observasi lapangan. Analisis yang dilakukan menggunakan metode analisis deskriptif kualitatif untuk menganalisis tahapan perubahan pada Klaster Batik Laweyan dan invoasi kelembagaannya. Hasil penelitian ini menunjukkan bahwa ada pengaruh inovasi kelembagaan tersebut. Ini ditunjukkan dari tumbuhnya rasa kenyamanan dan kepercayaan dalam ikatan sosial yang terbentuk antara sesama anggota klaster, rasa diterima dan kesepakatan pada tujuan bersama Forum Pengembangan Klaster Batik Laweyan (FPKBL) sebagai norma baru dalam manajemen kelembagaan Batik Laweyan. Hal tersebut berpengaruh terhadap peningkatan jumlah anggota yang bekerjasama, inovasi dagang dan peningkatan upaya menciptakan iklim bisnis. Jaringan klaster tersebut juga tumbuh secara eksternal dengan agen perjalanan dan pariwisata, bidang akademis, swasta, LSM, dan pemerintah.</p><p> </p>
Analisis Persepsi Masyarakat terhadap Pengelolaan Kawasan Mangrove Teluk Kotania
Authors: Nanlohy Hellen , Bambang Azis Nur , Ambaryanto Ambaryanto , Hutabarat Sahala 
Published: March 2016

<p class="Abstract">Pembangunan wilayah pesisir berkembang dengan pesat seiring dengan pertumbuhan penduduk yang cukup tinggi akan mengancam kelangsungan kawasan dan ekosistem pesisir. Kawasan mangrove yang berada di wilayah pesisir di teluk Kotania menjadi kawasan yang mendapat tekanan secara ekologis yang sangat mempengaruhi kelestariannya. Kesadaran masyarakat pesisir sangat penting dalam upaya pelestarian kawasan mangrove. Penelitian ini dilakukan dengan tujuan untuk menganalisis kesadaran masyarakat terhadap pengelolaan kawasan mangrove secara berkesinambungan dan lestari. Metode yang digunakan adalah penelitian survei pada lima dusun di teluk Kotania dengan metode deskritif yang bersifat studi kasus dan pembagian persepsi atas sepuluh kategori penilaian, data dikumpulkan melalui wawancara, observasi dan didukung oleh data sekunder. Deskripsi penelitian ini dengan memfokuskan pada persepsi masyarakat dalam pengelolaan kawasan mangrove teluk Kotania. Analisa data digunakan pendekatan secara deskritif kualitatif yang menggunakan rataan skor dengan rentang skala.Hasil analisis menunjukkan bahwa sebahagian besar masyarakat pesisir di teluk Kotania sangat setuju bahwa; 1) Kawasan mangrove di Teluk Kotania saat ini perlu/penting untuk dikelola agar dapat lestari, 2) Bentuk pengelolaan kawasan mangrove yang dilakukan harus melibatkan seluruh penduduk setempat, 3) Perlu adanya kerjasama antara pemerintah dan masyarakat setempat dalam kegiatan pengelolaan kawasan mangrove.<strong> </strong></p>
Une lecture chinoise d’Arnold Toynbee: Zhang Junmai et le problème de la continuité historique de la culture chinoise
Authors: Ciaudo Joseph 
Published: March 2016

Abstract
The historical continuity of Chinese culture from the early dynasties to modern times is a common topic in Chinese “culturalist discourses”. The intellectuals who wanted to defend the legitimacy of a Chinese culture compatible with modernity almost never put it into question. Zhang Junmai (1887–1969), in a short book entitled the Chinese culture of tomorrow (1936) had the same attitude toward the problem. He spoke about the ‘four thousand years of Chinese civilization’. However, taking this stand is not without raising issues, for Zhang begins his text by building his theory of cultures upon many ideas defended by Arnold Toynbee, in his major work A study of History (1931). As a matter of fact, Toynbee used to divide the history of China into two periods: the Sinic society, and the Far Eastern society. In introducing Toynbee’s studies in China, did Zhang purposely change important aspects of the Study or was he simply lost in translation? Incidentally, was quoting Toynbee simply instrumental in Zhang’s discourse? These are the main questions this research note aims at tackling.
Component Sharing Across Product Categories Leads to Functional Diversification: Evidence from the Japanese Digital Audio-Visual Products Market
Authors: Miura Sayako 
Published: March 2016

Abstract
This study focuses on component sharing across product categories, in contrast to earlier studies which examined component sharing within a specific category. Cross-category component sharing creates the potential for diversified product functionality by transferring new knowledge between categories, in addition to streamlining development, as previously noted. We collected evidence for this proposal from the Japanese digital audio-visual products market in the late 2000s. Panasonic not only shared software modules and the design of large scale integration (LSI) among products in the same category, but also shared them among televisions and DVD recorders. Its competitors, Sony and Sharp, used shared software and the design of LSI only within a product category. Panasonic products were functionally more advanced than those of Sony and Sharp. This study revealed two types of functionality diversification – simple functional diversification and linked operations.
The pathophysiological basis of bone tissue alterations associated with eating disorders
Authors: Greco Emanuela A. , Lenzi Andrea , Migliaccio Silvia 
Published: March 2016

Abstract
Anorexia nervosa (AN) and obesity are two major eating disorders present nowadays in Western countries. They are both characterized by striking body composition variations and hormonal alterations, which impact on skeletal metabolism, inducing bone tissue modifications and, thus, often cause an increased risk for fractures. AN and obesity are characterized by a severe reduction in fat mass and a high expression of it, respectively, and in both conditions hormones secreted or modulated by body fat content are important determinants of low bone density, impaired bone structure and reduced bone strength. In addition, in both AN and obesity, increased marrow adiposity, which correlates with low bone density, has been observed. This review will discuss the pathophysiological basis of bone alterations associated with AN and obesity, conditions of extreme energy deficiency and excess, respectively.
Crystal structure of N,N-bis(diphenylphosphanyl)cyclohexylamine, C30H31NP2
Authors: Naicker Dunesha , Pansuriya Pramod B. , Friedrich Holger B. 
Published: March 2016

Abstract
C30H31NP2, monoclinic, P21/n, a = 15.8251(19) Å, b = 10.3667(12) Å, c = 15.900(2) Å, β = 107.225(3)°, V = 2491.5(5) Å3, Z = 4, R
gt
(F) = 0.0390, wR
ref
(F
2
) = 0.0935, T = 163 K.
Seniorengenossenschaften
Authors: Rudel Miriam , Görtler Edmund , Abraham Martin 
Published: March 2016

Zusammenfassung
Der demografische Wandel macht eine Suche nach alternativen, kostengünstigen und gesellschaftlich akzeptierten Unterstützungs-, Wohn- und Pflegeformen notwendig. Seniorengenossenschaften können einen Beitrag im vorpflegerischen Bereich leisten, um Lebensqualität zu sichern und eine Heimunterbringung auf einen späteren Zeitpunkt im Lebenszyklus zu verschieben. Durch eine hohe Akzeptanz vor allem bei jüngeren Älteren ist die genossenschaftliche Idee der Unterstützung bei Hilfebedarf eine zukunftsträchtige Möglichkeit der gesellschaftlichen Sorge vor Ort.
FDA Approval Summary: Nivolumab for the Treatment of Metastatic Non-Small Cell Lung Cancer With Progression On or After Platinum-Based Chemotherapy
Authors: Kazandjian Dickran , Suzman Daniel L. , Blumenthal Gideon , Mushti Sirisha , He Kun , Libeg Meredith , Keegan Patricia , Pazdur Richard 
Published: March 2016

Abstract
On October 9, 2015, the U.S. Food and Drug Administration expanded the nivolumab metastatic non-small cell lung cancer (NSCLC) indication to include patients with nonsquamous NSCLC after a 3.25-month review timeline. Approval was based on demonstration of an improvement in overall survival (OS) in an international, multicenter, open-label, randomized trial comparing nivolumab to docetaxel in patients with metastatic nonsquamous NSCLC with progression on or after platinum-based chemotherapy. The CheckMate 057 trial enrolled 582 patients who were randomized (1:1) to receive nivolumab or docetaxel. Nivolumab demonstrated improved OS compared with docetaxel at the prespecified interim analysis with a hazard ratio (HR) of 0.73 (p = .0015), and a median OS of 12.2 months (95% CI: 9.7–15.0 months) in patients treated with nivolumab compared with 9.4 months (95% CI: 8.0–10.7 months) in patients treated with docetaxel. A statistically significant improvement in objective response rate (ORR) was also observed, with an ORR of 19% (95% CI: 15%–24%) in the nivolumab arm and 12% (95% CI: 9%–17%) in the docetaxel arm. The median duration of response was 17 months in the nivolumab arm and 6 months in the docetaxel arm. Progression-free survival was not statistically different between arms. A prespecified retrospective subgroup analysis suggested that patients with programmed cell death ligand 1-negative tumors treated with nivolumab had similar OS to those treated with docetaxel. The toxicity profile of nivolumab was consistent with the known immune-mediated adverse event profile except for 1 case of grade 5 limbic encephalitis, which led to a postmarketing requirement study to better characterize immune-mediated encephalitis.
Darut Taubah Pesantren and Commercial Sex Workers Saritem in Bandung
Authors: Saepudin Juju 
Published: March 2016

<p><em></em><em>The establishing a pesantren in a prostitution area is a very interesting topic to be<br />studied. This is because the challenge would be different from building a pesantren in<br />other community situations. This article based on the research on the roles of Darut<br />Taubah pesantren in teaching of moral values to commercial sex workers at Saritem<br />prostitution area. This is a qualitative case study research using a phenomenology <br />approach. Data was gathered using observation, in-depth interview, and documentary <br />research. Data was analyzed utilizing inductive approach. Finding of this study shows<br />that the establishment of Darut Taubah pesantren was motivated by cultural and<br />structural factors. Moreover, teaching of moral values was conducted through reorganizing structural and instrumental elements using many ways namely; persuasive method and prioritizing the roles of pesantren, teaching moral values and developing the social roles. After the existence of Darut Taubah pesantren in Saritem area, the prostitution<br />activities decrease significantly either in terms of quantity or intensity.</em></p><p><strong><em> </em></strong></p>
The Islamic Movement at Khairun University Ternate
Authors: Irfan Syuhudi Muhammad 
Published: March 2016

<p>This article aims to describe Islamic religious thought of Muslim student at Khairun<br />University in Ternate and the dynamic of religious movement organizations on campus. Informants of this study were selected using purposive method including activists of Islamic organizations, students, and lecturers of the university. Data were collected using interviews, observation, and documentation, and searching data related to social context of the study from the internet. Findings of the research shows that the type of religious understanding and nationality of Muslim students after the reformation era at Khairun University began experiencing a shift since the presence of trans-national organizations, such as the Indonesian Muslim Student Action Union (KAMMI), Campus Propagation Institute (LDK), Hizbut Tahrir (HT), and Wahdah Islamiyah (WI). Those organizations adopt fundamentalists thought who want purification of Islam, and anti-tradition. Nationality thought adopted by these organizations is a country that imposes Islamic law and Establishes a state of Khilafah (HT). Nevertheless, most students at the Khairun University embrace cultural Islam, following the footsteps of their parents and Ternate society in general.</p>
ASSOCIAÇÃO ENTRE O IMC, %G E A RCQ EM MENINAS ESCOLARES
Authors: Souza William Cordeiro de , Mascarenhas Luis Paulo Gomes , Tajes Junior Douglas , Muniz Marcos Aurélio Borges , Brasilino Fabrício Faitarone 
Published: March 2016

O presente estudo teve como objetivo relacionar os métodos de avaliação da composição corporal IMC, %G e a relação cintura-quadril em meninas escolares. A amostra intencional foi constituída por 55 crianças do sexo feminino com idades entre 10 e 14 anos. Foi coletado o peso e a estatura para calculo do IMC, sendo calculado a partir da fórmula: IMC= Peso (kg)/altura (m)². Na verificação do %G, foi utilizado o protocolo de Slaughter que sugere a soma das Dobras Cutâneas (DC) do Tríceps e Panturrilha Medial (TR+PM). E foi coletado os dados da circunferência da cintura e circunferência do quadril para cálculo da RCQ, utilizando a seguinte formula: RCQ= Cintura (cm)/Quadril (cm). Para o tratamento estatístico foi utilizado o software BioEstat 5.0, aonde se calculou a estatística descritiva (Média, DP e percentual de frequência (%)), foi realizado o teste de normalidade de Spearman para prever a utilização de testes paramétricos para determinação do grau de correlação entre o IMC, %G e a RCQ com nível de significância em p<0,05. Foi encontrada correlação significativa entre IMC x %G (r= 0,762; p=<0,001); e o mesmo não ocorreu entre IMC x RCQ (r= 0, 225; p=0,097) e entre %G x RCQ (r= 0,180; p=0,186). Pode-se concluir que existem correlações significativas entre IMC e o %G, o que se pode observar que não ocorreu entre IMC e a RCQ e entre %G e a RCQ em crianças de 10 a 14 anos de idade.