bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantio‐ and Diastereoselective Desymmetrization of 1,1’‐Biaryl‐2,6‐Dicarbaldehydes by Copper‐Catalyzed 1,2‐Addition of Silicon Nucleophiles
Authors: Xiao Yao , Zhao Zhi‐Yuan , Irran Elisabeth , Oestreich Martin 
Published: September 2024

AbstractA desymmetrizing 1,2‐addition of silicon nucleophiles to biaryl derivatives containing an 2,6‐dicarbaldehyde‐1‐yl unit is reported. The reaction is catalyzed by copper with a triazolium‐ion‐derived N‐heterocyclic carbene as the chiral ligand and makes use of an Si–B reagent as the silicon pronucleophile. The practical methodology furnishes axially chiral aromatic carbaldehydes decorated with a centrally chiral α‐hydroxysilane moiety in moderate to good yields and with high enantio‐ as well as excellent diastereoselectivities. The silicon nucleophile always attacks at the diastereotopic face of either carbonyl group away from the ortho substituent on the phenyl ring at C1 of the 2,6‐dicarbaldehyde‐1‐yl fragment. The resulting axially and centrally chiral products can be further converted into valuable biaryl compounds with hardly any erosion of the enantiomeric excess.
Chemical Synergic Stabilization of High Br‐Content Mixed‐Halide Wide‐Bandgap Perovskites for Durable Multi‐Terminal Tandem Solar Cells with Minimized Pb Leakage
Authors: Yang Meifang , Tan Ying , Yang Guo , Chang Xueqing , Tian Tian , Li Wen‐Guang , Fang Yuxuan , Shen Jinliang , Yang Shaopeng , Wu Wu‐Qiang 
Published: September 2024

AbstractHigh Br‐content lead mixed‐halide perovskites with wide‐bandgap (WBG) of 1.6–2.0 eV have showcased vast potential to be used in tandem solar cells. However, WBG perovskites often suffer from severe halide segregation, phase separation and ion migration under the stress of light, heat, moisture and electric bias, which would accelerate the decomposition of perovskite films and thus deteriorate the photovoltaic performance and even aggravate the lead leakage from damaged devices. Here, we report a novel chemical synergic interaction strategy to mitigate the abovementioned issues in WBG perovskites. To achieve that, a small amount of cationic β‐cyclodextrin, composed of multiple ammonium cations, chlorine ions and abundant hydroxyl functional groups, was introduced into WBG perovskites, which effectively stabilized the halide ions and homogenized the phase distribution, comprehensively passivated the crystallographic defects, as well as efficiently immobilized the Pb2+ ions. Encouragingly, the cationic β‐cyclodextrin was universal and useful for different WBG perovskite compositions (i.e. 1.68 eV, 1.79 eV and 1.99 eV), which favorably boosted the efficiencies by 10 %–36 % and extended the operational stability of resultant devices to 2680 h. The four‐terminal all‐perovskite tandem and six‐terminal all‐perovskite tandem solar cells integrated with different WBG perovskite sub‐cells exhibited efficiencies up to 24.39 % and 22.42 %, respectively. More importantly, we demonstrated the cationic β‐cyclodextrin‐assisted internal chemical encapsulation effectively prevented the Pb leakage when the devices were severely damaged and immersed in water. Surprisingly, there was only 5.63 ppb Pb leaching out for the single‐junction devices, far below than the U.S. standard for safe drinking water (<15 ppb). The target tandem solar cells with cationic β‐cyclodextrin modification also realized a Pb sequestration efficiency of 93.4 % under the most adverse environment.
Copper(I) Complexes With Phenanthroline‐Functionalized NHC Ligands Achieve Effective Anticancer Activity via Mitochondrial and Endoplasmic Reticulum Stress
Authors: Chen Chao , Zheng Yilun , Rao Hong , Huang Fan , Shen Chao , Lu Chunxin 
Published: September 2024

ABSTRACTCopper complexes exhibit promising anticancer properties, which can be further promoted by suitable ligands. In this study, we synthesized and investigated the anticancer effects of three copper(I) complexes with N‐heterocyclic carbene (NHC) ligands derived from phenanthroline‐functionalized imidazole salts. The synthesis of these NHC‐copper(I) complexes (Cu1‐Cu3) was meticulously characterized using NMR and elemental analysis; their crystal structures were further delineated by X‐ray diffraction. Our findings illustrate the unique geometric configurations of these complexes: Cu1 features a dinuclear arrangement with off‐linear geometry; Cu2 and Cu3 are characterized by a bi‐copper core stabilized by two phenanthroline‐modified carbene ligands. Crucially, in vitro cytotoxic evaluations revealed that these complexes possess suitability anticancer activity. Among them, Cu2 exhibited enhanced cytotoxicity activity, achieving a half‐maximal inhibitory concentration (IC50) of 4.36 ± 0.25 μM in colon cancer cell line HCT‐116, markedly surpassing the efficacy of cisplatin. Subsequent investigations elucidated that Cu2 notably increases intracellular reactive oxygen species (ROS) levels and induces mitochondrial membrane depolarization and endoplasmic reticulum stress, leading to oxidative stress‐mediated apoptosis of colon cancer cells.
Singlet Oxygen‐Triggered Release of Nitric Oxide in an Endoperoxide‐Arginine Conjugate
Authors: Zhang Guangyu , Wang Lei , Qiao Yuan , Sun Rensong , Liu Ziang , Akkaya Engin U. 
Published: September 2024

AbstractNitric oxide (NO) is an important signaling molecule in both healthy and pathological processes. In this work, we present the first example of a novel class of organic NO‐donor compounds with minimal toxicity. The release is driven by the reaction of singlet oxygen spontaneously produced by the cycloreversion reaction of the endoperoxide. Cell culture and imaging data confirms the release of NO in this bimodular system.
Quadrotor attitude control with a modified fixed‐time synergetic controller: A geometric analysis and experimental validation
Authors: Achour Saadi , Mokhtari Khalil , Rahmoune Abdelaziz 
Published: September 2024

AbstractThis article proposes a novel modified fixed‐time synergetic control (MFTSC) approach to address the quadrotor control problem in the presence of external disturbances. In contrast to previous fixed‐time synergetic control (FTSC) methods, the proposed approach employs an aggregate macrovariable expression with independent fractional powers. This expression expands the set of real numbers that the parameters of the fractional power can take, leading to a significantly higher rate of convergence toward optimal control parameters (more than 28‐fold), as demonstrated through geometric analysis. The stability of the proposed control system is established, and numerical simulations and experimental validation are conducted using a quadrotor test bench to corroborate the theoretical results.
Effect of Chloride Ions on the Electrochemical Performance of Magnesium Metal‐Organic‐Frameworks‐Based Semi‐Solid Electrolytes
Authors: Elnagar Mohamed M. , Hassan Hagar K. , Kibler Ludwig A. , Jacob Timo 
Published: September 2024

AbstractThe majority of research on magnesium (Mg) electrolytes has focused on enhancing reversible Mg deposition, often employing chloride‐containing electrolytes. However, there is a notable gap in the literature regarding the influence of chloride ions in semi‐solid Mg electrolytes. In this study, we systematically explore the impact of chloride ions on Mg deposition/dissolution on a copper (Cu) anode using a semi‐solid electrolyte composed of Mg‐based mixed metal‐organic frameworks, MgCl2 and Mg[TFSI]2. We separate the Mg deposition/dissolution process from changes in the anode's surface morphology In this respect, the morphological and compositional transformations in the electrolyte and electrode following galvanostatic cycling are meticulously investigated. Initial potential cycling reveals the feasibility of Mg deposition/dissolution on Cu electrodes, albeit with reduced reversibility in subsequent cycles. Extending the upper potential limit to 4.0 V vs. Mg/Mg2+ enhances Mg dissolution, attributed to chloride ions facilitating Cu surface dissolution. Our findings provide insights into optimizing semi‐solid electrolytes for advanced Magnesium battery technologies.
Evaluating video feedback to improve eSports performance in Street Fighter V
Authors: White Romel , Miltenberger Raymond , Concepcion Anthony 
Published: September 2024

AbstracteSports is a newly rising field with rapidly increasing cultural validity. Despite the wide array of similarities between eSports and traditional sports, behavioral skill acquisition interventions have yet to be applied to video game skills. Although video feedback has been established as effective for traditional sports, further research is needed to validate its efficacy as a standalone intervention. In this study, the effects of video feedback were analyzed with three participants in a nonconcurrent multiple baseline across subjects design. Participants performed a specific in‐game behavior (an anti‐air attack) in a controlled match against the researcher, then viewed recordings of their performance and received positive and corrective feedback from the researchers. The generalization of the skill improvement was evaluated through the rate of successful skill implementation in ranked online matches. Results showed that the video feedback intervention improved performance over baseline for all participants and generalized to online matches.
Plectalibertellenone A suppresses colorectal cancer cell motility and glucose metabolism by targeting TGF‐β/Smad and Wnt pathways
Authors: Gamage Chathurika D. B. , Kim Jeong‐Hyeon , Zhou Rui , Park So‐Yeon , Pulat Sultan , Varlı Mücahit , Nam Sang‐Jip , Kim Hangun 
Published: September 2024

AbstractColorectal cancer (CRC) is the second most common cause of cancer‐related death and represents a serious worldwide health problem. CRC metastasis decreases the survival rate of cancer patients, underscoring the need to identify novel anticancer agents and therapeutic targets. Here, we introduce Plectalibertellenone A (B) as a promising agent for the inhibition of CRC cell motility and glucose metabolism and explore its mechanism of action in CRC cells. Plectalibertellenone A suppressed TGF‐β gene expression and the activation of the TGF‐β/Smad signaling pathway, leading to reverse epithelial to mesenchymal transition (EMT) by modulating the expressions of EMT markers and transcriptional factors such as E‐cadherin, N‐cadherin, vimentin, Slug, Snail, Twist, and ZEB1/2. Furthermore, disruption of Wnt signaling inhibited CRC motility and glucose metabolism including glycolysis and oxidative phosphorylation, primarily affecting glycolytic enzymes, GLUT1, HK2, PKM2, LDHA, and HIF‐1α under hypoxic condition. Therefore, Plectalibertellenone A is a potential drug candidate that can be developed into a promising anticancer treatment to prevent CRC metastasis and inhibit glucose metabolism.
Active diagnostic ingredients (ADIs) for PCR: A mini‐bioreactor producing dNTPs with silica immobilized R5‐kinases
Authors: Bird Anna R. , Hall Elizabeth A. H. 
Published: September 2024

AbstractLow availability of routine nucleic acid amplification testing (NAAT) during infection outbreaks, especially in less resourced environments, was highlighted by the Covid pandemic. One of the barriers lies with the supply chain and cost of the active diagnostic ingredients (ADIs) that are the reagents for NAATs. This work explores a novel synthesis method to produce a key NAAT reagent, namely the 2′‐deoxynucleoside 5′‐triphosphate (dNTPs), via a reusable enzyme bioreactor, that can be integrated into a NAAT workflow. A self‐immobilizing R5‐silaffin kinase fusion enzyme was designed for immobilization on silica, converting dNMPs to their respective dNTP ADIs for PCR in a R5‐kinase mini‐bioreactor, designed to be implemented in a reusable device, stable over 2 months, when stored at 4°C. The performance is demonstrated for PCR reactions of the lambda genome and showed successful amplification up to 7.5 kb. In comparison with commercial dNTPs, in Plasmodium malariae NAATs, a high linear correlation was shown between the Ct value and the log(Copy Number), with lower incidence of false positives than with the commercial dNTPs. Overall a pathway to generate deoxynucleotides from monophosphate precursors was demonstrated, and an immobilized enzyme mini‐bioreactor investigated as a proof‐of‐principle for work‐flow integration with NAAT in low‐resource research and diagnostics labs.
Investigation of Phytochemical Composition, Radical Scavenging Potential, Anti‐Obesogenic Effects, and Anti‐Diabetic Activities of Kaempferia parviflora Rhizomes
Authors: Prabakaran Sangeetha , Saad Hazwani Mat , Tan Chun Hoe , Syed Abdul Rahman Syarifah Nur , Sim Kae Shin 
Published: September 2024

AbstractKaempferia parviflora or commonly known as “Kunyit hitam” by locals, is an edible plant, native to tropical regions, has been extensively utilized for culinary and medicinal applications. The present study aimed to investigate the phytochemical composition and biological activities of the rhizomes of K. parviflora. The ethanol crude and fractionated extracts (hexane and chloroform) of the rhizomes were evaluated for their total phenolic content, total steroidal content, as well as antioxidant, anti‐obesogenic, and anti‐diabetic activities. The chloroform extract demonstrated the highest concentration of plant sterols (432±0.23 mg BSE/g extract) and a substantial amount of phenolic compounds (1.19×103±0.41 mg GAE/g extract). Gas chromatography‐mass spectrometry (GC/MS) analysis revealed that the chloroform extract of the rhizomes is predominantly composed of bioactive flavonoids including tectochrysin (1), 5,7‐dimethoxyflavone (2), 3,5,7‐trimethoxyflavone (3), 3,4’,5,7‐tetramethoxyflavone (4), and 4’,5,7‐trimethoxyflavone (5). Furthermore, the chloroform extract exhibited the highest overall radical scavenging and α‐glucosidase inhibitory activities, which can be attributed to the presence of compounds 1–5 in the extract. Collectively, these findings suggest that the chloroform extract of the rhizomes of K. parviflora is a potentially valuable source of bioactive compounds with antioxidant, anti‐obesogenic, and anti‐diabetic properties, with potential application in therapeutics and functional foods.
Evaluation of Antibacterial Activity of Bismuth Ferrites Nanoparticles in the Inhibition of E. Coli and S. Aureus Bacteria
Authors: Pancotti Alexandre , de Barros Souza Mauro Vinícius , Santos Abreu Amanda , Rodrigues Rezende Stefane , Lázaro Moreli Marcos , Uceda Otero Enrique , Landers Richard , Soares Roniere , Wang Jiale 
Published: September 2024

AbstractIn this work, bismuth ferrites (BFO) nanoparticles were produced in the form of using sol‐gel technique, followed by annealing in a tube furnace in temperatures from 400 °C to 650 °C. X‐ray diffraction (XRD) results showed the formation of small sizes nanoparticles (NPs) with high purity. Structural analysis displayed that annealing at 600 °C could make BFO NPs be fitted to rhombohedral space group (R3c), with small quantity of spurious phases. The sizes of the BFO nanoparticles determined by transmission electron microscopy (HRTEM) are between 50 to 100 nm. To evaluate the efficiency of BFO in antimicrobial susceptibility tests, the nanoparticles were dispersed through cand tested agar diffusion method and dilution in a 96 well plate using a Gram‐positive strains (Staphylococcus aureus) and Gram negative strain (Escherichia coli). The antibacterial activity of the BFO NPs was tested at concentrations of 2 mg/mL with MIC greater than 60 μg/mL for both bacteria.
Outcomes of transcatheter closure for coronary artery fistulas with or without aneurysm: A comparative study
Authors: Wei Peijian , Pu Zuo , Chan Jeffrey S. K. , Li Yihang , Xu Liang , Wan Junyi , Zhang Fengwen , Tse Gary , Wang Shouzheng , Ouyang Wenbin , Zhang Gejun , Fang Fang , Pan Xiangbin 
Published: September 2024

AbstractBackgroundCoronary Artery Fistulas (CAFs) Patients with aneurysm may face severe complications, necessitating prompt treatment. However, data on the outcomes of transcatheter closure in CAFs patients with aneurysm are notably scarce.MethodsThis retrospective study included all consecutive CAFs patients who underwent transcatheter closure at Fuwai Hospital from January 2010 to December 2023. Patients were divided into two groups based on the presence of aneurysm, and baseline characteristics, anatomical features, and transcatheter closure outcomes were further compared.ResultsThe study ultimately included 104 patients, consisting of 56 in the aneurysm group and 48 in the non‐aneurysm group. Patients in the aneurysm group were younger [39.79 (16.35) versus 50.69 (13.31) years, p < 0.001] and more frequently present with heart murmurs (21.43% vs. 6.25%, p = 0.03). Multivariate logistic regression indicated that a larger fistula diameter and the presence of CCFs are independent risk factors for the presence of aneurysm in CAF patients. The procedural success rate (75% vs. 75%, P = 1), fistula recanalization rate (11.11% vs. 16.67%, p = 0.42), and reintervention rate (3.7% vs. 6.25%, p = 0.89) were similar between the aneurysm and non‐aneurysm groups.ConclusionA larger fistula diameters and the presence of coronary‐cameral fistulas are independent risk factors for the occurrence of aneurysms in patients with CAFs. The outcomes of transcatheter closure are comparable for CAFs patients with and without aneurysm, though post‐closure thrombosis within the fistula appears to be more common in patients with aneurysm.
Valorization of Glycerol to Glycerol Carbonate and Glycidol by Different Dialkyl Carbonates Utilizing Tricalcium Aluminate Hexahydrate as Transesterification Catalyst
Authors: Szabó Yvette , Nagy Sándor Balázs , Anna Ádám Adél , Mészáros Rebeka , Kónya Zoltán , Kukovecz Ákos , Sipos Pál , Szabados Márton 
Published: September 2024

AbstractIn this study, we report a base‐catalyzed transesterification reaction of glycerol, a waste product of the biodiesel industry, with various dialkyl carbonates, which act both as reactants and solvents, to convert glycerol carbonate into an industrially useful molecular building block. The catalyst, being used for the first time, is also a waste product from industry, present in bauxite residues and in the Portland cement, simply known as tricalcium aluminate. Despite being well‐known and readily available, this solid is only extremely poorly researched catalyst, nevertheless, using dimethyl and diethyl carbonate, glycerol conversion rates >80% and glycerol carbonate yields >60% could be achieved in just 1 h (under air atmosphere and reflux). In a comparison of the performance with other catalysts commonly researched today, as well as with other components of red mud and cements, the results showed that tricalcium aluminate is excellent, cheap, and largely environmentally friendly material for this purpose. Reusability studies of the catalysts have also shown that they provide high conversion and product yields even after repeated use, although different material characterization techniques showed intense glycerol‐catalyst surface interaction and intermediate product formation, the deactivating side effects of which could be avoided by catalyst regeneration steps.
Advances in Catalytic Hydrogenation of Liquid Organic Hydrogen Carriers (LOHCs) Using High‐Purity and Low‐Purity Hydrogen
Authors: Ramadhani Safira , Dao Quan Nguyen , Imanuel Yoel , Ridwan Muhammad , Sohn Hyuntae , Jeong Hyangsoo , Kim Keunsoo , Yoon Chang Won , Song Kwang Ho , Kim Yongmin 
Published: September 2024

AbstractLiquid organic hydrogen carriers (LOHCs) are emerging as a promising solution for global hydrogen logistics. The LOHC process involves two primary chemical reactions: hydrogenation for hydrogen storage and dehydrogenation for hydrogen reconversion. In the exothermic hydrogenation reaction, hydrogen‐lean compounds are converted to hydrogen‐rich compounds, storing hydrogen from various sources such as water electrolysis, fossil fuel reforming, biomass processing, and industrial by‐products. Conversely, hydrogen is extracted from hydrogen‐rich compounds through an endothermic dehydrogenation reaction and supplied to several hydrogenation utilization offtakers. This review article discusses the development trends in catalytic hydrogenation processes for various LOHC materials, including benzene, toluene, naphthalene, biphenyl‐diphenylmethane, benzyltoluene, dibenzyltoluene, and N‐ethylcarbazole. It introduces references for catalytic hydrogenation processes utilizing both high‐purity and low‐purity (alternatively, mixed) hydrogen feedstocks, with particular emphasis on low‐purity hydrogen applications. The direct storage of hydrogen with minimal purification, using by‐product hydrogen and mixed hydrogen from hydrocarbon and biomass reforming, is crucial for the economic viability of this hydrogen carrier system.
Improved Heat Transfer Capabilities of Nanofluids—An Assessment Through CFD Analysis
Authors: Khalid Rehan Zubair , Iqbal Mehmood , Hassan Aitazaz , Haris Syed Muhammad , Ullah Atta 
Published: September 2024

AbstractConventional fluids used in fission‐based water‐cooled nuclear reactors have lower heat transfer coefficients (HTCs) and thermal conductivity, which has led researchers to explore high‐performance fluids that can enhance heat transfer in routine operation and prevent core meltdown in the case of accidents. It is important to investigate a wide range of fluids that can help designers improve thermal hydraulic characteristics, such as HTC, critical heat flux, and minimum departure from nucleate boiling ratio (MDNBR). In this study, the effectiveness of nanofluids in enhancing heat transfer parameters, including thermal conductivity and heat capacity, was investigated. Four different nanofluids (Al2O3–H2O, ZrO2–H2O, Ag–H2O, and Si–H2O) with pure water as the primary coolant in an HPR‐1000 nuclear reactor were compared using computational methods. Due to computational limitations, only the flow channel among four fuel rods with the highest power density in the core was simulated using Eulerian computational fluid dynamics. The results of this study show that silver water (Ag–H2O) nanofluid outperformed other nanofluids and pure water. It had a higher average HTC and MDNBR, with a 67.15 % and 45.23 % improvement, respectively, compared to pure water. The fuel rod wall temperature was also reduced by 28.5 K with Ag–H2O compared to water. Comparison of current simulated results with literature data shows a good agreement.
Improvement of Photocatalytic CO2 Reduction with Conjugated Organic Polymers by Rational Modulation of Donor, Acceptor and Bonding Method
Authors: Li Xinhao , Ma Tiantian , Dou Zhiyuan , Wang Qingqing , Cai Hanwen , Gu Guoxian 
Published: September 2024

AbstractThe use of metal‐free catalysts to convert CO2 into valuable chemicals is very challenging. Here, we synthesized a conjugated organic polymer (TpTf‐1) featuring 2,4,6‐Triphenyl‐1,3,5‐Triazine as the acceptor unit, triphenylamine as the donor unit, and vinylidene bond as the linkage. The local structure of donor‐acceptor (D−A) forms an intramolecular electric field that can promote the separation of photogenerated electrons and charges, meanwhile, the vinylidene bond can further change the charge distribution to promote exciton dissociation. Without the use of photosensitizers, the TpTf‐1 exhibits outstanding selectivity of CO of up to 91.96 %, with a production rate of 45.2 μmol g−1 h−1 at visible light, which is 3.4‐fold than TaTf‐1 with the same D−A structure but linking in imine bond and is 2.8‐fold than TpTf‐2 linking in vinylidene bond but with a different donor unit. Moreover, TpTf‐1 has a CO production rate of up to 117.3 μmol g−1 h−1 under full wavelength light irradiation.