bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of C‐reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs
Authors: Severo Julia So , Santana Aline Elisa , Aoki Valeria , Michalany Nilceo S. , Mantovani Matheus Matioli , Larsson Carlos Eduardo , Larsson Carlos Eduardo 
Published: November 2017

BackgroundC‐reactive protein (CRP) is a major acute phase protein in dogs and may be an inflammatory marker of autoimmune diseases.Hypothesis/ObjectivesTo measure pre‐ and post‐treatment CRP levels in dogs with superficial pyoderma (SP) and pemphigus foliaceus (PF) compared to normal dogs; to evaluate possible correlation between CRP values, indirect immunofluorescence (IIF), and pemphigus foliaceus extent and severity index (PEFESI) scores.AnimalsFifty nine dogs divided into three groups: Group I (control, n = 31), Group II (SP, n = 14) and Group III (PF, n = 14).MethodsCRP levels were measured in Group I dogs. Skin biopsies of Groups II and III dogs were obtained for histopathological examination. In Group II dogs, CRP levels were measured at days 0, 15, 30 and 60. In Group III dogs were evaluated by PEFESI, IIF and CRP levels at days 0, 15, 30, 60 and 90.ResultsGroup III showed a higher median CRP (37.4 mg/mL) compared to the other groups (Group I, CRP 2.9 mg/mL, P < 0.0001; Group II CRP 3.8 mg/mL, P = 0.008). There was no significant difference in CRP levels between groups I and II. IIF titres and CRP levels decreased in most cases of PF with clinical improvement. Dogs with CRP >10.6 μg/mL were 5.5 times more likely to have PF than SP. There was a strong positive correlation between CRP values and PEFESI and a weak positive correlation between CRP values and IIF titres.Conclusion and clinical importanceCRP levels are increased in dogs with PF and exceed levels found in most dogs with SP.
Frost tolerance, regeneration capacity after frost exposure and high photosystem II efficiency during winter and early spring support high winter survival in Juncus spp.
Authors: Østrem L , Folkestad J , Solhaug K A , Brandsæter L O 
Published: November 2017

SummaryDuring the past two decades, significant spread of the perennial weeds Juncus effusus (soft rush) and Juncus conglomeratus (compact rush) in coastal parts of Norway seems to have coincided with an observed rise in winter temperatures. This study investigated the frost tolerance (LT50) and effects of moderate frost exposure on rush plant regrowth over time during the period late November to late winter/spring, and photosynthetic activity in late winter/spring. Juncus effusus and J. conglomeratus of physiologically young age (seedlings) displayed similar high frost tolerance (LT50) and did not differ significantly in regenerative ability following prolonged frost exposure. Regrowth capacity generally increased during winter and when stress conditions increased, shoot formation was prioritised over total biomass production. Maximum quantum efficiency of photosystem II (Fv/Fm) and performance index of photosystem II (PI) were high in late winter/spring, with J. effusus showing higher values than J. conglomeratus. Green, photosynthetically active shoots, which facilitate accumulation of carbohydrates during autumn and even in winter, may provide Juncus spp. with substantial competitiveness in late winter and spring. The results revealed that the dominance of J. effusus over J. conglomeratus in pastures and leys is not due to major differences in winter survival parameters, but probably the higher photosynthetic efficiency observed in J. effusus. Generally higher temperatures during winter and lower frost kill may be contributing to the current increase in rush infestation.
Complete Chloroplast Genome Sequence of
Chenopodium album
from Northeastern India
Authors: Devi Rajkumari Jashmi , Thongam Biseshwori 
Published: November 2017

ABSTRACT

Chenopodium album
belongs to the complex genus
Chenopodium
of the family Amaranthaceae. It is an economically and medicinally important plant. We report here the first complete chloroplast genome sequence of
C. album
from northeastern India. This study shall add extensive information on the evolutionary relationships of the genus
Chenopodium
.
Complete Chloroplast Genome Sequence of Cane Needle Grass,
Nassella hyalina
(Poaceae: Stipeae)
Authors: Wang Aisuo , Wu Hanwen , Gopurenko David 
Published: November 2017

ABSTRACT

Nassella hyalina
(cane needle grass) is on the Alert List for Environmental Weeds in Australia. We present here the first complete chloroplast sequence of
N. hyalina
reconstructed from Illumina whole-genome sequencing. The complete chloroplast sequence is 137,606 bp in size and has a gene content and structure similar to those of other published chloroplast genomes of Stipeae.
Draft Genome Sequences of Aggregatibacter actinomycetemcomitans Strains 310a and 310b
Authors: May Anthony C. , Ohta Hiroyuki , Maeda Hiroshi , Kokeguchi Susumu , Cugini Carla 
Published: November 2017

ABSTRACT

We report the draft genome sequences of
Aggregatibacter actinomycetemcomitans
strains 310a (310-TR) and 310b (310-OS). Strain 310a is a clinical isolate with a rough phenotype. Strain 310b is a laboratory-adapted isolate derived from the passage of 310a and displays a smooth phenotype.
Draft Genome Sequence of
Burkholderia puraquae
Type Strain CAMPA 1040, Isolated from Hospital Settings in Córdoba, Argentina
Authors: Leguizamon Mariana , Draghi Walter O. , Montanaro Patricia , Schneider Andy , Prieto Claudia I. , Martina Pablo , Lagares Antonio , Lasch Peter , Bosch Alejandra 
Published: November 2017

ABSTRACT

We report here the draft genome sequence of
Burkholderia puraquae
type strain CAMPA 1040, a member of the
Burkholderia cepacia
complex. This strain, isolated from a hemodialysis water reservoir, harbors several stress tolerance genes, such as the systems for low oxygen survival, for copper tolerance, and for osmotic stress resistance.
Complete Genome Sequence of a Novel Variant of Wenzhou Mammarenavirus
Authors: Liu Meng-meng , Li Li-li , Wang Xiao-feng , Duan Zhao-jun 
Published: November 2017

ABSTRACT

Wenzhou mammarenavirus (WENV) is a novel species of
Arenavirus
that was first detected in China. We report here a novel WENV variant (WENV G107) from liver samples of
Rattus norvegicus
that shares 84.7% to 86.8% (large [L] segment) and 84.2% to 87.8% (small [S] segment) nucleotide sequence identity with its closest relative. The genomic characteristics were analyzed based on the whole genome of WENV G107.
Metagenome of the Siberian Underground Water Reservoir
Authors: Kadnikov Vitaly V. , Frank Yulia A. , Mardanov Andrey V. , Beletsky Alexey V. , Karnachuk Olga V. , Ravin Nikolai V. 
Published: November 2017

ABSTRACT

We report on the metagenome of a deep subsurface aquifer in the Tomsk region of Russia, sampled via an oil exploration borehole drilled to a depth of 2.8 km. Methanogenic archaea were present in the water along with members of various bacterial phyla, including
Firmicutes
,
Chloroflexi
,
Bacteroidetes
,
Ignavibacteriae
, and uncultured candidate divisions.
Complete Genome Sequences of Two Plant-Associated Pseudomonas putida Isolates with Increased Heavy-Metal Tolerance
Authors: Nesme Joseph , Cania Barbara , Zadel Urška , Schöler Anne , Płaza Grażyna A. , Schloter Michael 
Published: November 2017

ABSTRACT

We report here the complete genome sequences of two
Pseudomonas putida
isolates recovered from surface-sterilized roots of
Sida hermaphrodita
. The two isolates were characterized by an increased tolerance to zinc, cadmium, and lead. Furthermore, the strains showed typical plant growth-promoting properties, such as the production of indole acetic acid, cellulolytic enzymes, and siderophores.
First Complete Genome Sequences of Anopheles A Virus of the Genus
Orthobunyavirus
Authors: Hughes Holly R. , Russell Brandy J. , Lambert Amy J. 
Published: November 2017

ABSTRACT
Here, we report the first complete genome sequence of Anopheles A virus (ANAV) that was isolated from Colombia in 1940, and we include the first description of the medium and large segments. The ANAV medium and large segments share the highest identity with serogroup member Lukuni virus, which causes human infection.
Draft Genome Sequence of Pseudomonas fluorescens Strain TR3, a Potential Biocontrol Agent against the Rice Blast Fungus Magnaporthe oryzae
Authors: Zhang Xue , Xu Jin-Rong , Nakatsu Cindy H. 
Published: November 2017

ABSTRACT

We present the draft genome sequence of the potential biocontrol agent
Pseudomonas fluorescens
TR3, which was isolated from rice leaves infected with
Magnaporthe oryzae
in a greenhouse. The genome of TR3 was assembled into 26 scaffolds (~6 Mbp) and includes genes potentially involved in bacterial interactions with fungi.
The Whole-Genome Sequence of Bacillus velezensis Strain SB1216 Isolated from the Great Salt Plains of Oklahoma Reveals the Presence of a Novel Extracellular RNase with Antitumor Activity
Authors: Marasini Daya , Cornell Carolyn R. , Oyewole Opeoluwa , Sheaff Robert J. , Fakhr Mohamed K. 
Published: November 2017

ABSTRACT

The whole-genome sequence of
Bacillus velezensis
strain SB1216, isolated from the Great Salt Plains of Oklahoma, showed the presence of a 3,814,720-bp circular chromosome and no plasmids. The presence of a novel 870-bp extracellular RNase gene is predicted to be responsible for this strain’s antitumor activity.
Complete Genome Sequences of Plasmid-Bearing Multidrug-Resistant Campylobacter jejuni and Campylobacter coli Strains with Type VI Secretion Systems, Isolated from Retail Turkey and Pork
Authors: Marasini Daya , Fakhr Mohamed K. 
Published: November 2017

ABSTRACT

We report the complete genome sequences of multidrug-resistant
Campylobacter jejuni
and
Campylobacter coli
isolated from retail turkey and pork, respectively. The chromosomes of these two isolates contained type VI secretion system genes. The two isolates also harbored large plasmids with antimicrobial resistance genes possibly contributing to their multidrug resistance.
Local anaesthetics combined with vasoconstrictors in patients with cardiovascular disease undergoing dental procedures: systematic review and meta-analysis protocol
Authors: Guimaraes Caio Chaves , Lopes Motta Rogério Heládio , Bergamaschi Cristiane de Cássia , Araújo Jimmy de Oliveira , Andrade Natalia Karol de , Figueiró Mabel Fernandes , Ramacciato Juliana Cama , Lopes Luciane Cruz 
Published: November 2017

IntroductionThe use of vasoconstrictors combined with local anaesthetics (LAs) in dentistry for patients with cardiovascular disease (CVD) is still controversial in the scientific literature. It raises concerns regarding the possibility of transient episodes, triggering negative cardiovascular outcomes.Method/designTrials eligible for our systematic review will enrol patients with CVD who have undergone dental treatments carried out with the use of LAs by comparing two arms: LAs with vasoconstrictors and LAs without vasoconstrictors. The research will be conducted in the electronic databases, namely Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Healthstar (via Ovid), Cumulative Index to Nursing and Allied Health Literature and Web of Science, from their inception to December 2017, without any restrictions in terms of language and status of publication. A team of reviewers will independently assess titles, abstracts and complete text to determine eligibility. For eligible studies, the same reviewers will perform data extraction and evaluate the risk of bias in the selected articles. The selected outcomes comprise death, mortality by a specific cause, stroke, acute myocardial infarction, hospitalisation, pain, bleeding, arrhythmias, ischaemic episodes, anxiety, adverse effects, changes in blood pressure, changes in heart rate, anxiety and results obtained via oximetry. Whenever possible, we will conduct a meta-analysis to establish the effects of LAs with and without vasoconstrictors in the patients with CVD, and the overall quality of evidence for each outcome will be determined using the Grading of Recommendations Assessment, Development and Evaluation classification system.Ethics and disseminationEthics committee approval was not necessary because this is a protocol of systematic review. This systematic review will be submitted for presentation at conferences and for publication in a peer-reviewed journal. Our review will assess the risks of cardiovascular events when using LAs with and without vasoconstrictors in patients with CVD, focusing on important clinical outcomes.PROSPERO registration numberCRD42016045421.
Revealing the complexity of quitting smoking: a qualitative grounded theory study of the natural history of quitting in Australian ex-smokers
Authors: Smith Andrea L , Carter Stacy M , Dunlop Sally M , Freeman Becky , Chapman Simon 
Published: November 2017

ObjectiveTo explore the quitting histories of Australian ex-smokers in order to develop an understanding of the varied contribution of smoking cessation assistance (either pharmacotherapy or professionally mediated behavioural support) to the process of quitting.DesignQualitative grounded theory study; in-depth interviews.Participants37 Australian adult ex-smokers (24–68 years; 15 men, 22 women) who quit in the past 6–24 months.ResultsAlthough participants’ individual quitting histories and their overall experiences of quitting were unique, when the 37 quitting histories were compared it was clear two experiences were common to almost all participants: almost no one quit at their first quit attempt and almost everyone started out quitting unassisted. Furthermore, distinct patterns existed in the timing and use of assistance, in particular the age at which assistance was first used, how some participants were resolutely uninterested in assistance, and how assistance might have contributed to the process of successful quitting even if not used on the final quit attempt. Importantly, three patterns in use of assistance were identified: (1) only ever tried to quit unassisted (n=13); (2) started unassisted, tried assistance but reverted back to unassisted (n=13); (3) started unassisted, tried assistance and quit with assistance (n=11). For most participants, insight into what quitting would require was only gained through prior quitting experiences with and without assistance. For a number of participants, interest in assistance was at its lowest when the participant was most ready to quit.ConclusionQuitting should be viewed as a process drawing on elements of assisted and unassisted quitting rather than a stand-alone event that can be labelled as strictly assisted or unassisted.
Wnt/β-Catenin Pathway Activation Mediates Adaptive Resistance to BRAF Inhibition in Colorectal Cancer
Authors: Chen Guangming , Gao Chenxi , Gao Xuan , Zhang Dennis Han , Kuan Shih-Fan , Burns Timothy F. , Hu Jing 
Published: November 2017

Abstract
One of the most encouraging developments in oncology has been the success of BRAF inhibitors in BRAF-mutant melanoma. However, in contrast to its striking efficacy in BRAF-mutant melanomas, BRAF inhibitor monotherapy is ineffective in BRAF-mutant colorectal cancer. Although many studies on BRAF inhibitor resistance in colorectal cancer have focused on mechanisms underlying the reactivation of the EGFR/RAS/RAF/MEK/ERK pathway, the current study focuses on identifying novel adaptive signaling mechanisms, a fresh angle on colorectal cancer resistance to BRAF inhibition. We found that treatment with BRAF inhibitors (both current and next-generation BRAF inhibitors) upregulated the Wnt/β-catenin pathway in BRAFV600E-mutant colorectal cancer cell lines through activating the cytoplasmic tyrosine kinase focal adhesion kinase (FAK). The results showed that FAK activation upon BRAF inhibitor treatment did not require EGFR or ERK1/2 activation, implying that BRAF inhibitor treatment-induced hyperactivation of Wnt signaling is “pathway reactivation”-independent. BRAF inhibition–induced Wnt pathway activation was further validated in preclinical models of BRAFV600E-mutant colorectal cancer, including cell line xenograft model and a patient-derived xenograft model. Combined inhibition of BRAF/Wnt pathways or BRAF/FAK pathways exerted strong synergistic antitumor effects in cell culture model and mouse xenograft model. Overall, the current study has identified activation of the Wnt/β-catenin pathway as a novel fundamental cause of colon cancer resistance to BRAF inhibition. Our results suggest that although complete vertical pathway blockade is pivotal for effective and durable control of BRAF-mutant colorectal cancer, cotargeting parallel adaptive signaling—the Wnt/β-catenin pathway—is also essential. Mol Cancer Ther; 17(4); 806–13. ©2017 AACR.
Narratives of the Prophet’s Early Life in Ṣaḥīḥ Al-Buḫārī: An Analytical Study of Qurʾānic References in Sīra Nabawiyya
Authors: Azmi Ahmad Sanusi 
Published: November 2017

Abstract
Research into early Muslim sources has demonstrated that some verses of the Qurʾān have been seen by Muslim scholars as containing direct references to the events of the Prophet’s early life. Modern scholars, however, have questioned the appropriateness and authority of these Qurʾānic references as being accurate sources of information for the Prophet’s biography. Since the ḥadīṯ are regarded as an authoritative exegetical tool for understanding the meaning of Qurʾānic verses, the ḥadīṯ and scholars’ views on the scripture and its relationship to the narratives of sīra nabawiyya must be undertaken. The objectives of this present study are to explore the narratives of the Prophet’s early life as found in Ṣaḥīḥ al-Buḫārī and analyse al-Buḫārī’s perspective on the role of ḥadīṯ as an exegetical tool for Qurʿānic references in sīra nabawiyya. The study is qualitative in nature, as it utilises both critical and analytical approaches for its methodology. The study suggests that al-Buḫārī employed innovative and novel approaches when presenting narratives of the Prophet’s early life. At certain places in his al-Ṣaḥīḥ, by adducing certain ḥadīṯ in detail, al-Buḫārī endeavours to convey one distinctive and irrevocable message to the reader.
A Comparative Study on Interpretation of Planet from Al-Quran and Astronomy Views
Authors: Wahid Khairussaadah , Nawawi Mohd Saiful Anwar Mohd , Man Saadan 
Published: November 2017

Abstract
The interpretation submitted by the translator of mashaf Quran against the pronouncement of al-kawkab and al-kawakib means ‘star’. Based on the studies from the modern astronomy, both words refer to a planet. The study of the meaning of al-kawkab and al-kawakib is about explaining more appropriate meanings based on the context of Islamic astronomy. The main objective of this study is to identify the meaning of al-kawkab and al-kawakib terms in al-Quran and to analyze the correlation between Quranic commentaries with modern discoveries of planets in the solar system. Methods of comparison between the views of Quranic commentaries and modern astronomy are highlighted with reference based on classical and contemporary tafseers, and modern astronomy literature. The study found that there are four passages that discuss physical characteristics of planets. In addition, the reason that may be adduced to explain appropriate translations for the words al-kawkab and al-kawakib as ‘planet’ is based on the majority of Quranic commentaries and research on the difference in physical nature of planets and stars. In conclusion, the is no difference between Quranic commentaries and modern astronomy related to planets and their features. Thus the pronouncement of al-kawkab and al-kawakib in the Quran refers to a planet, not a star.
Idealism of Jihad and War from the Qurʾanic Perspective
Authors: Mohd Khambali@Hambali Khadijah , Abdullah Mustaffa , Ali Abdul Karim 
Published: November 2017

Abstract
There are various verses in the Qurʾan which apparently lead to the meaning of war. With regard to its intepretation of its related verses, there are mainly two different views. The first view argues that war in Islam will not happen but in a defensive manner. In other words, a war among Muslims would not happen unless they have been attacked and their reaction is in the form of counter attack in order to protect their dignity and life. The second view sees war in offensive manner. It is considered as a holy war (jihād) which is under the category of striving in the cause of Allah, and recommended to gain the status of martyrdom (syahīd).
These different views create variant intepretations of the word jihād and war. The existance of certain groups related to terrorism such as Islamic State of Iraq and al-Syam (isis), al-Qaeda, Abu Sayyaf, Jemaah Islamiyyah and others, abusing the name of Islam and using hostile approaches in order to achieve their aims, have clearly a negative impact on Islam.
This article reviews the meaning of jihād and war in accordance to the Qurʾanic perspective in order to address this issue fairly. Relevant data have been taken from selected authoritative Qurʾanic exegesis pertaining to verses of jihād and war. It uses content analysis to analyse those related data.The article concludes that jihad in Islam is subject to sincere intention and a clear objective: it does not simply mean fighting. A war should be viewed from different aspects whether defensive or offensive because different backgounds will lead to the both. Both jihad and war are clearly different from terrorism, and both of them are associated with the meaning of fī sabīllah as commonly understood.
An Audit of Audits: Are we Completing the Cycle?
Authors: Gnanalingham Janaki , Gnanalingham Muhuntha G , Gnanalingham Kanna K 
Published: November 2017

Clinical audit plays an important part in the drive to improve quality of patient care and thus forms a cornerstone of clinical governance. We evaluated the standard of clinical audits conducted by all departments in a teaching hospital between 1996 and 1997. Of a total of 213 audits carried out, 102 (48%) were ‘partial’ and only 29 (14%) were ‘full’. Recommendations for improvement emerged from 134 (63%) of the audits performed. In only 51 audits (24%) was the cycle completed by re-auditing, during the subsequent 3 years. Most departments undertake clinical audits but failure to close the loop undermines their effectiveness and wastes resources.
Students Sitting Medical Finals–-Ready to be House Officers?
Authors: Goodfellow P B , Claydon P 
Published: November 2017

An initial survey of students approaching qualification and the preregistration house officer year revealed anxiety about competence in several important clinical skills. A questionnaire study was then undertaken to assess, first, the extent to which students had attained the skills required for the preregistration year and, second, the amount of training in these skills provided during the preregistration year. 122 medical students taking their final examinations were asked about training and practice in eight core clinical skills, and 84 graduates from the same school, approaching the end of their preregistration year, were asked about postgraduate training in these skills. The response rate of each group was 100%. Of the eight skills studied, most had been performed few times by the students at qualification. Less than half the current preregistration house officers could recall training being given in any of the skills studied. There were no significant differences in house-officer training between teaching hospitals and district general hospitals. Regarding needlestick injuries, nearly two-thirds of preregistration house officers were unable to recall any training at either undergraduate or postgraduate level. These results suggest that training in clinical skills can be improved. Training is already changing with use of clinical skills laboratories and logbooks. We also recommend mandatory needlestick training both in undergraduate programmes and in induction courses for preregistration house officers.