bluuebunny/crossref_metadata_2025_split huggingface dataset:
Depression, Resource Utilization, and Outcomes Following Liver Transplant
Authors: Sebaaly Jamielynn C. , Fleming James , Pilch Nicole , Meadows Holly , Finn Anastasia , Chavin Kenneth , Baliga Prabhakar , Bratton Charles F. , McGillicuddy John W. , Nadig Satish , Taber David 
Published: June 2016

Context: There is evidence that depression after liver transplant (LTX) is associated with increased morbidity and mortality; however, the effect of depression treatment on LTX outcomes has not been well established. Objective/Setting/Design: This single-center, longitudinal cohort study aimed to determine whether depression treatment influences outcomes after LTX. Depression diagnosis was based on medical history and documentation from psychosocial providers. Patients/Intervention/Main Outcome Measures: Patients were studied from October 2010 to June 2013 and separated into 3 groups for analysis: no depression, adequately treated depression, and inadequately treated depression. Adequacy of depression treatment was determined using the Antidepressant Treatment History Form. Results: Of the 161 patients included in the analysis, 103 did not have depression, 24 had adequately treated depression, and 34 had inadequately treated depression. Baseline demographics were similar between the groups. Patients with inadequately treated depression had significantly more encounters with a health-care provider ( P = .03). Graft loss tended to be higher in these patients (27% in the inadequately treated group, 17% in the adequately treated, and 14% in the no depression group, P = .25). The adequately treated group was more likely than the inadequately treated group to be on antidepressants at 30 days post-LTX ( P = .001). The inadequately treated group was more likely to be on a sleep aid 30 days post-LTX ( P = .01). Conclusion: Inadequately treated depression led to increased health-care resource utilization. Patients with adequately treated depression had similar outcomes as those with no depression. Use of sleep aids early post-LTX may be a surrogate indicator of inadequately treated depression.
Mastering Together the Highs and Lows
Authors: Beckmann Sonja , Künzler-Heule Patrizia , Biotti Beatrice , Spirig Rebecca 
Published: June 2016

Context: Self-management in chronic illness involves complex medical, role-related, and emotional tasks. Still, while self-management support of patients and their families has become a cornerstone of chronic illness care, information is limited as to how liver transplant (LTx) patients and close caregivers perceive self-management before and after transplantation. Objective: To explore self-management tasks in view of medical, role-related, and emotional tasks in LTx candidates and recipients and their respective close caregivers. Design and Participants: For this qualitative study, focus group interviews were conducted and analyzed using knowledge mapping according to the 3 above-noted self-management categories. German-speaking adults who were wait-listed for or had received LTx and who were being treated in University Hospital Zurich or who were close caregivers to such patients were eligible for participation. As patients’ data were closely related to those of the caregivers, the 2 groups’ data sets were merged during the final development of themes. Results: Thirty participants comprised 7 focus groups. The main theme was “The current state of health determines the daily rhythm.” The essence of how patients and caregivers described their self-management tasks is compiled in “Mastering together the highs and lows” which comprises 3 core themes: mastering medical management, managing roles together, and managing the highs and lows of emotion. Conclusion: Patients and close caregivers prioritized self-management tasks as follows: first medical, then role-related, and finally emotional management. Over the course of LTx, health-care professionals should acknowledge this ranking while providing individualized support to both patients and caregivers.
Go-sha-jinki-Gan (GJG) ameliorates allodynia in chronic constriction injury model mice via suppression of TNF-α expression in the spinal cord
Authors: Nakanishi Miho , Nakae Aya , Kishida Yuki , Baba Kousuke , Sakashita Noriko , Shibata Masahiko , Yoshikawa Hideki , Hagihara Keisuke 
Published: June 2016

Background Alternative medicine is noted for its clinical effect and minimal invasiveness in the treatment of neuropathic pain. Go-sha-jinki-Gan, a traditional Japanese herbal medicine, has been used for meralgia and numbness in elderly patients. However, the exact mechanism of GJG is unclear. This study aimed to investigate the molecular mechanism of the analgesic effect of GJG in a chronic constriction injury model. Results GJG significantly reduced allodynia and hyperalgesia from the early phase (von Frey test, p < 0.0001; cold-plate test, p < 0.0001; hot-plate test p = 0.011; two-way repeated measures ANOVA). Immunohistochemistry and Western blot analysis revealed that GJG decreased the expression of Iba1 and tumor necrosis factor-α in the spinal cord. Double staining immunohistochemistry showed that most of the tumor necrosis factor-α was co-expressed in Iba1-positive cells at day 3 post-operation. GJG decreased the phosphorylation of p38 in the ipsilateral dorsal horn. Moreover, intrathecal injection of tumor necrosis factor-α opposed the anti-allodynic effect of GJG in the cold-plate test. Conclusions Our data suggest that GJG ameliorates allodynia in chronic constriction injury model mice via suppression of tumor necrosis factor-α expression derived from activated microglia. GJG is a promising drug for the treatment of neuropathic pain induced by neuro-inflammation.
Reducing cranial computed tomography effective radiation dose by 30% using adaptive iterative dose reduction
Authors: Yu Wai-Yung , Ho Thye Sin , Ko Henry , Chan Wai-Yee , Ong Serene , Hui Francis Kim Hoong 
Published: June 2016

Introduction: The use of computed tomography (CT) imaging as a diagnostic modality is increasing rapidly and CT is the dominant contributor to diagnostic medical radiation exposure. The aim of this project was to reduce the effective radiation dose to patients undergoing cranial CT examination, while maintaining diagnostic image quality. Methods: Data from a total of 1003, 132 and 27 patients were examined for three protocols: CT head, CT angiography (CTA), and CT perfusion (CTP), respectively. Following installation of adaptive iterative dose reduction (AIDR) 3D software, tube current was lowered in consecutive cycles, in a stepwise manner and effective radiation doses measured at each step. Results: Baseline effective radiation doses for CT head, CTA and CTP were 1.80, 3.60 and 3.96 mSv, at currents of 300, 280 and 130–150 mA, respectively. Using AIDR 3D and final reduced currents of 160, 190 and 70–100 mA for CT head, CTA and CTP gave effective doses of 1.29, 3.18 and 2.76 mSv, respectively. Conclusion: We demonstrated that satisfactory reductions in the effective radiation dose for CT head (28.3%), CTA (11.6%) and CTP (30.1%) can be achieved without sacrificing diagnostic image quality. We have also shown that iterative reconstruction techniques such as AIDR 3D can be effectively used to help reduce effective radiation dose. The dose reductions were performed within a short period and can be easily achievable, even in busy departments.
Sinonasal aspergillosis in a British Shorthair cat in the UK
Authors: Tamborini Alice , Robertson Elise , Talbot Jessica J , Barrs Vanessa R 
Published: June 2016

Case summary A 13-year-old, castrated male, British Shorthair cat presented for investigation of chronic, intermittent, bilateral epistaxis and stertor. CT revealed severe asymmetric bilateral intranasal involvement with extensive turbinate lysis, increased soft tissue attenuation and lysis of the sphenopalatine bone and cribriform plate. On retroflexed pharyngoscopy, a plaque-like mass occluded the choanae. Rostral rhinoscopic examination revealed extensive loss of nasal turbinates, necrotic tissue and mucosal fungal plaques in the left nasal cavity. The right nasal cavity was less severely affected. The nasal cavities were debrided extensively of plaques and necrotic tissue. Aspergillus fumigatus was isolated on fungal culture, and species identity was confirmed using comparative sequence analysis of the partial β-tubulin gene. On histopathology of nasal biopsies, there was ulcerative lymphoplasmacytic and neutrophilic rhinitis, and fungal hyphae were identified on nasal mucosa, consistent with a non-invasive mycosis. The cat was treated with oral itraconazole after endoscopic debridement, but signs relapsed 4.5 months from diagnosis. Residual left nasal fungal plaques were again debrided endoscopically and oral posaconazole was administered for 6 months. Fourteen months from diagnosis, the cat remains clinically well with mild intermittent left nasal discharge secondary to atrophic rhinitis. Relevance and novel information This is the first case of rhinoscopically confirmed sinonasal aspergillosis to be diagnosed in a cat in the UK. Endoscopic confirmation of resolution of infection is useful in cases where mild nasal discharge persists after treatment.
Mechanisms of platelet-mediated liver regeneration
Authors: Lisman Ton , Porte Robert J. 
Published: June 2016

Abstract
Platelets have multiple functions beyond their roles in thrombosis and hemostasis. Platelets support liver regeneration, which is required after partial hepatectomy and acute or chronic liver injury. Although it is widely assumed that platelets stimulate liver regeneration by local excretion of mitogens stored within platelet granules, definitive evidence for this is lacking, and alternative mechanisms deserve consideration. In-depth knowledge of mechanisms of platelet-mediated liver regeneration may lead to new therapeutic strategies to treat patients with failing regenerative responses.
Risk Factors and Outcomes for Patients With Follicular Lymphoma Who Had Histologic Transformation After Response to First-Line Immunochemotherapy in the PRIMA Trial
Authors: Sarkozy Clémentine , Trneny Marek , Xerri Luc , Wickham Nick , Feugier Pierre , Leppa Sirpa , Brice Pauline , Soubeyran Pierre , Gomes Da Silva Maria , Mounier Christiane , Offner Fritz , Dupuis Jehan , Caballero Dolores , Canioni Danielle , Paula Marlton , Delarue Richard , Zachee Pierre , Seymour John , Salles Gilles , Tilly Hervé 
Published: June 2016

Purpose To study the outcome of histologic transformation (HT) in a large prospective cohort of patients with follicular lymphoma (FL) who previously responded to immunochemotherapy. Patients and Methods After a median 6-year follow-up of 1,018 randomly assigned patients from the PRIMA trial, disease progression was observed in 463 patients, 194 of whom had histologic documentation. Results Forty patients had histology consistent with HT, and 154 had untransformed FL (median time to recurrence, 9.6 v 22.8 months, respectively; P = .018). Thirty-seven percent of biopsies performed during the first year of follow-up showed HT corresponding to 58% of all HTs. Altered performance status, anemia, high lactate dehydrogenase level, “B” symptoms, histologic grade 3a, and high Follicular Lymphoma International Prognostic Index scores at diagnosis were identified as HT risk factors. Response (complete v partial) to immunochemotherapy or rituximab maintenance had no impact on the risk of HT. After salvage treatment, patients with HT had less frequent complete response (50.3% v 67.4%; P = .03) and more disease progression (28.2% v 9.6%; P < .001) than patients without HT. Estimated overall survival for the patients with HT was poorer (median, 3.8 v 6.4 years; hazard ratio, 3.9; 95% CI, 2.2 to 6.9). Autologous stem cell transplantation improved the outcomes of patients with HT (median overall survival, not reached v 1.7 years) but not of patients with persistent FL histology. Conclusion HT in patients with FL who previously responded to immunochemotherapy is an early event associated with a poor outcome that may deserve intensive salvage with autologous stem cell transplantation. These data emphasize the necessity for biopsy at the first recurrence of FL.
Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial
Authors: Smyth Elizabeth C. , Fassan Matteo , Cunningham David , Allum William H. , Okines Alicia F.C. , Lampis Andrea , Hahne Jens C. , Rugge Massimo , Peckitt Clare , Nankivell Matthew , Langley Ruth , Ghidini Michele , Braconi Chiara , Wotherspoon Andrew , Grabsch Heike I. , Valeri Nicola 
Published: June 2016

Purpose The Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) trial established perioperative epirubicin, cisplatin, and fluorouracil chemotherapy as a standard of care for patients with resectable esophagogastric cancer. However, identification of patients at risk for relapse remains challenging. We evaluated whether pathologic response and lymph node status after neoadjuvant chemotherapy are prognostic in patients treated in the MAGIC trial. Materials and Methods Pathologic regression was assessed in resection specimens by two independent pathologists using the Mandard tumor regression grading system (TRG). Differences in overall survival (OS) according to TRG were assessed using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate analyses using the Cox proportional hazards method established the relationships among TRG, clinical-pathologic variables, and OS. Results Three hundred thirty resection specimens were analyzed. In chemotherapy-treated patients with a TRG of 1 or 2, median OS was not reached, whereas for patients with a TRG of 3, 4, or 5, median OS was 20.47 months. On univariate analysis, high TRG and lymph node metastases were negatively related to survival (Mandard TRG 3, 4, or 5: hazard ratio [HR], 1.94; 95% CI, 1.11 to 3.39; P = .0209; lymph node metastases: HR, 3.63; 95% CI, 1.88 to 7.0; P < .001). On multivariate analysis, only lymph node status was independently predictive of OS (HR, 3.36; 95% CI, 1.70 to 6.63; P < .001). Conclusion Lymph node metastases and not pathologic response to chemotherapy was the only independent predictor of survival after chemotherapy plus resection in the MAGIC trial. Prospective evaluation of whether omitting postoperative chemotherapy and/or switching to a noncross-resistant regimen in patients with lymph node-positive disease whose tumor did not respond to preoperative epirubicin, cisplatin, and fluorouracil may be appropriate.
T-DM1 Activity in Metastatic Human Epidermal Growth Factor Receptor 2–Positive Breast Cancers That Received Prior Therapy With Trastuzumab and Pertuzumab
Authors: Dzimitrowicz Hannah , Berger Michael , Vargo Craig , Hood Annette , Abdelghany Osama , Raghavendra Akshara Singareeka , Tripathy Debu , Valero Vicente , Hatzis Christos , Pusztai Lajos , Murthy Rashmi 
Published: June 2016

Purpose Ado-trastuzumab emtansine (T-DM1) is currently approved for treatment in patients with human epidermal growth factor receptor 2 (HER2)–positive, metastatic breast cancer (MBC) who previously received trastuzumab and a taxane. However, there are no data on the activity of T-DM1 in patients who received prior pertuzumab, which is now included as standard first-line therapy. The goal of this study was to assess the efficacy of T-DM1 in routine clinical practice in a contemporary patient population that received both prior trastuzumab and pertuzumab. Patients and Methods We identified all patients with HER2-positive MBC who received T-DM1 after trastuzumab and pertuzumab between March 1, 2013, and July 15, 2015, via electronic pharmacy records and departmental databases at three institutions: MD Anderson Cancer Center, Smilow Cancer Hospital at Yale, and The James Cancer Hospital at the Ohio State University. We reviewed medical records of each case to confirm treatment sequencing and outcome. Results Of patients, 82 were identified and 78 were available for outcome analysis; 32% received T-DM1 as first- and second-line line therapy, and 48% received it as fourth-line treatment or later. Rate of prolonged duration on therapy, defined as duration on therapy ≥ 6 months, was 30.8% (95% CI, 20.6% to 41.1%), and tumor response rate was 17.9% (95% CI, 9.4% to 26.4%). Median duration on therapy was 4.0 months (95% CI, 2.7 to 5.1; range, 0 to 22.5 months). T-DM1 was discontinued for disease progression in 84% of patients and for toxicity in 10%. Conclusion Tumor response rates were lower than in prior reports of trastuzumab-resistant, HER2-positive MBC, but one third of patients received therapy with T-DM1 for ≥ 6 months, which suggests a clinically relevant benefit in patients who received prior pertuzumab.
Fabrication and Photocurrent Generation Properties of Insoluble Hierarchical Polythiophene Thin Films Prepared by Sequential Electrochemical Polymerization
Authors: Kumagawa Yu , Akiyama Tsuyoshi , Nishimura Yuki , Goto Koji , Suzuki Atsushi , Oku Takeo 
Published: June 2016

Abstract
Insoluble hierarchical polybithiophene/poly(ethylenedioxythiophene) thin films with a double-layered structure were prepared on an indium tin oxide transparent electrode by sequential electrochemical polymerization. The formation of the hierarchical structure was supported by the transmission absorption spectra and Raman scattering spectra of the double-layered polythiophene thin films. In the presence of residual oxygen as an electron acceptor, light irradiation on the polythiophene-modified electrodes generated stable cathodic photocurrents. A broad peak at approximately 440 nm corresponding to the absorption of neutral polythiophene was observed in the incident photon to current conversion efficiency profile of the polybithiophene/poly(ethylenedioxythiophene)-modified electrode. The photocurrent density of the polybithiophene/poly(ethylenedioxythiophene)-modified electrode was higher than that of the poly(ethylenedioxythiophene)-modified electrode.
Uma boa história ajuda a vender mais. E agora?
Authors: Garcia Solimar 
Published: June 2016

Ana Claudia Teixeira fundou a Comidinhas da Itália e logo despontou como uma empreendedora de sucesso, industrializando massas frescas. Porém, após desentendimentos com sua sócia Luísa, Ana Claudia passou a ser o alvo de uma avalanche de notícias negativas sobre a falsidade da história de seu principal produto. O caso foi pensado para ser aplicado em disciplinas de marketing de qualquer curso de graduação e pós-graduação, bem como para a educação executiva.
Verba ou apoio político?
Authors: Da Silva Alex Junior Costa , De Abreu Julio Cesar Andrade 
Published: June 2016

O diretor de uma unidade acadêmica de uma universidade precisa tomar uma decisão com relação ao plano de realocação dos técnicos administrativos. A decisão envolve escolher entre verbas para instituição ou apoio político dos técnicos administrativos na próxima consulta eleitoral para o cargo. O caso se destina a cursos de graduação nas áreas de Administração Pública e Gestão de Recursos Humanos, em disciplinas como gestão de pessoas, gestão universitária, negociação e gestão de conflitos.
Προδιαγραφές σχεδιασμού προγράμματος επαγγελματικής ανάπτυξης από απόσταση για τους εκπαιδευτικούς των μειονοτικών σχολείων στη Θράκη
Authors: Αναστασιάδης Θεοδόσης , Μανούσου Ευαγγελία 
Published: June 2016

Πάντοτε επίκαιρη, η συζήτηση για την επιμόρφωση και επαγγελματική ανάπτυξη των εκπαιδευτικών, συνδέεται με οριοθετήσεις που αφορούν στην ποιότητα και αποτελεσματικότητα του σχολικού συστήματος. Στην περίπτωση των μειονοτικών σχολείων της Θράκης, ωστόσο, δεν μπορεί να διεξαχθεί ανεξάρτητα από το πολιτικό πλαίσιο, το οποίο επιδρά καθοριστικά στο σύνολο των εκπαιδευτικών θεμάτων και παρεμβάσεων. Η συγκεκριμένη συνθήκη, χαρακτηρίζεται από ιδιοτυπίες και ιδιαιτερότητες, για τις οποίες οι εκπαιδευτικοί βρίσκονται, συνήθως, απροετοίμαστοι καθώς εκλείπουν οι κατάλληλες δομές και μηχανισμοί υποστήριξης του έργου τους.Η εργασία διερευνά τη δυνατότητα αξιοποίησης της εξ αποστάσεως επιμόρφωσης, στοχεύοντας στη διαμόρφωση των προδιαγραφών και στο σχεδιασμό μιας πρότασης για την υποστήριξη της επαγγελματικής ανάπτυξης των εκπαιδευτικών που υπηρετούν στα σχολεία της μειονότητας στη Θράκη. Στην κατεύθυνση αυτή, παρουσιάζονται τα αποτελέσματα μιας έρευνας ποιοτικού χαρακτήρα, σχετικά με τις ανάγκες επιμόρφωσης, τις στάσεις απέναντι στη μέθοδο της εκπαίδευσης από απόσταση και τις προτιμήσεις για τη μορφή και οργάνωση αντίστοιχων προγραμμάτων. Με βάση τα ευρήματα που προέκυψαν, τις αρχές και τα χαρακτηριστικά της εξ αποστάσεως και της εκπαίδευσης ενηλίκων, τις εμπειρίες και την αξιολόγηση προγραμμάτων που υλοποιούνται διεθνώς, προτείνεται ένας εναλλακτικός τρόπος σχεδιασμού για την υλοποίηση της από απόσταση επιμόρφωσης στη συγκεκριμένη ομάδα- στόχο. Υποστηρίζεται πως ένα υβριδικό/ μεικτό εκπαιδευτικό μοντέλο, μπορεί να αποτελέσει τη βάση για την εφαρμογή προγράμματος που θα υποστηρίζει τη διαρκή επαγγελματική τους ανάπτυξη.
Επικοινωνία Καθηγητή –Συμβούλου και φοιτητών στις Σπουδές από απόσταση: Απόψεις φοιτητών στο πλαίσιο της Θ.Ε.ΕΚΠ65 του Ε.Α.Π.
Authors: Ηλιάδου Χρυσούλα , Αναστασιάδης Παναγιώτης 
Published: June 2016

Η αμφίδρομη επικοινωνία μεταξύ φοιτητή και διδάσκοντα και το καλά σχεδιασμένο εκπαιδευτικό υλικό αποτελούν τους σημαντικότερους παράγοντες για την επιτυχία ενός προγράμματος εξΑΕ που στοχεύει στο να οδηγήσει τον εκπαιδευόμενο σε μία ευρετική πορεία της γνώσης.Μέσω της αμφίδρομης επικοινωνίας ο διδάσκων διευκολύνει την αλληλεπίδραση και ενεργητική εμπλοκή του φοιτητή με το εκπαιδευτικό υλικό, κινητοποιεί το ενδιαφέρον του για εμβάθυνση στη μελέτη και συμβάλλει σημαντικά στη προσπάθεια του φοιτητή να διερευνήσει και να οικοδομήσει τις γνώσεις του. Επίσης, η ποιοτική επικοινωνία μεταξύ συμβούλου και φοιτητή λειτουργεί υποστηρικτικά με τη σαφή και επαρκή ανατροφοδότηση που πληροφορεί τον φοιτητή για την πρόοδό του και υπηρετεί τον εμψυχωτικό ρόλο του συμβούλου.Σε αυτήν την εργασία παρουσιάζεται η έρευνα που διεξήχθη στους φοιτητές της Θεματικής ενότητας ΕΚΠ65 (Ανοικτή και εξ Αποστάσεως Εκπαίδευση) του Ε.Α.Π. Σκοπός της ήταν να διερευνηθούν οι απόψεις των φοιτητών σχετικά με τη συχνότητα, το αντικείμενο και τους τρόπους επικοινωνίας με τον διδάσκοντα, καθώς και οι απόψεις τους για τη συνεισφορά της επικοινωνίας αυτής στην ολοκλήρωση των σπουδών τους. Μέσα από τις απαντήσεις τους, θα προσπαθήσουμε να ορίσουμε το πλαίσιο της αποτελεσματικής επικοινωνίας μεταξύ φοιτητή και Κ.Σ. και να συνθέσουμε το προφίλ του επιτυχημένου Κ.Σ. σύμφωνα με τη γνώμη των φοιτητών.
Απόψεις των μεταπτυχιακών φοιτητών της Θεματικής Ενότητας ΕΚΠ 65 «Ανοικτή και εξ Αποστάσεως Εκπαίδευση» για το ρόλο και την αποστολή του Καθηγητή Συμβούλου στο ΕΑΠ
Authors: Αναστασιάδης Παναγιώτης , Καρβούνης Λάμπρος 
Published: June 2016

Οι απαιτούμενες δεξιότητες του Καθηγητή Συμβούλου (Κ.Σ) στην εξ Αποστάσεως Εκπαίδευση κατηγοριοποιούνται σε τρεις κύριες κατηγορίες: οργανωτικές, κοινωνικές και παιδαγωγικές δεξιότητες. Οι τρεις αυτές κατηγορίες δεξιοτήτων συνθέτουν το ρόλο του Κ.Σ του ΕΑΠ, ο οποίος είναι να υποστηρίζει, να ενθαρρύνει, να αξιολογεί τους εκπαιδευόμενους σε όλη την διάρκεια των σπουδών τους. Η αξιολόγηση στην εκπαιδευτική διαδικασία και ιδιαίτερα η αξιολόγηση του Κ.Σ του ΕΑΠ ως παράγοντα της εκπαιδευτικής διαδικασίας είναι από τις πιο σημαντικές δραστηριότητες, που έχει στόχο τη βελτίωση του ίδιου του Κ.Σ και της εκπαιδευτικής διαδικασίας. Σκοπός της παρούσας εργασίας είναι να διερευνηθούν οι απόψεις των μεταπτυχιακών φοιτητών του ΕΑΠ, που παρακολουθούν την Θεματική Ενότητα ΕΚΠ 65 «Ανοικτή και εξ Αποστάσεως Εκπαίδευση», αναφορικά με τους άξονες και τα επιμέρους κριτήρια με βάση τα οποία θα μπορούσε να δομηθεί ένα πλαίσιο αποτίμησης του ρόλου και της αποστολής των Κ.Σ του ΕΑΠ.