bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do depression and anxiety profiles over time predict persistent post‐surgical pain? A study in cardiac surgery patients
Authors: Pagé M. Gabrielle , Watt‐Watson J. , Choinière M. 
Published: February 2017

AbstractBackgroundRates of depression and anxiety in cardiac surgery patients are higher than in the general population. The development of persistent post‐surgical pain (PPSP) in this population is also concerning. The objectives of this study were to (1) identify anxiety and depression trajectories of cardiac surgery patients over a 2‐year period; (2) examine demographic and clinical characteristics associated with trajectory memberships and (3) determine if anxiety and/or depression trajectories predict PPSP.MethodsA total of 1071 patients completed questionnaires before cardiac surgery and 7 days, 3, 6, 12 and 24 months thereafter. Models were run using growth mixture modelling.ResultsBoth anxiety and depression models yielded a 3‐trajectory solution. A minority of patients (< 10%) had unremitted major depression, almost one‐third of patients had remitted minor depression and the remaining patients had no depression over the 2‐year period. < 10% of patients had unremitted elevated anxiety, almost 40% of patients had unremitted mild anxiety symptoms, whereas half of patients did not experience anxiety over the same time period. Patients with unremitted elevated anxiety were more likely to report PPSP; the association between depression and PPSP was not significant.ConclusionsThe results' novelty lies in the identification of a homogeneous patient subgroup presenting with unremitted elevated anxiety which predicted the presence of PPSP up to 2 years following cardiac surgery. Unlike anxiety, depression subgroups were not predictive of PPSP status.SignificanceThis article presents the relationship between anxiety and depression profiles over 2 years in cardiac surgery patients and persistent post‐surgical pain. These results suggest the importance of evaluating how early identification and treatment of high‐risk patients could prevent PPSP. These results provide potential detection and prevention avenues of chronic pain for high‐risk patients based on their anxiety trajectory.
Voltammetric Determination of Valaciclovir Using a Molecularly Imprinted Polymer Modified Carbon Paste Electrode
Authors: El Gohary Nesrine Abdelrehim , Madbouly Adel , El Nashar Rasha Mohamed , Mizaikoff Boris 
Published: February 2017

AbstractA molecularly imprinted polymer (MIP) was rationally synthesized with the aid of computer based studies. The computational studies were used to screen for the most suitable template to functional monomer molar ratio. Two functional monomers were involved in the study (methacrylic acid and 4‐vinylpyridine). Four MIP ratios were synthesized in accordance with the results of the computational studies and their performance was evaluated using equilibrium rebinding assays. The MIP with the best performance was used as an additive in carbon paste electrodes for the voltammetric determination of valaciclovir (VCV). Following the optimization of voltammetric parameters, a linear response was obtained in the range of 1.0x10−6–7.0x10−4M with a limit of detection at 4.45x10−7M. The MIP modified carbon paste electrode was successfully applied for the determination of VCV in pure solutions and dosage form.
Effects of the herbicide triclopyr on metamorphic northern red-legged frogs
Authors: Yahnke Amy E. , Grue Christian E. , Hayes Marc P. , Pearman-Gillman Schuyler 
Published: February 2017

Abstract

Aquatic herbicides are used to manage invasive emergent plants in and around wetlands. Metamorphic frogs that emerge during the aquatic weed management season may be at risk of herbicide exposure. Metamorphic northern red-legged frogs (Rana aurora) were exposed to a triclopyr tank mix labeled for control of broadleaf emergent aquatic weeds such as invasive purple loosestrife (Lythrum salicaria). The tank mix consisted of Renovate® 3 (triclopyr triethylamine salt 44.4%), the modified vegetable oil surfactant Competitor®, and the marker dye Hi-Light®. Metamorphs were exposed to the tank mix and a clean-water control for 96 h, and then reared in clean water for 60 d. Exposure to the tank mix resulted in no treatment-related mortalities, no effects on behavior immediately post exposure, and no effects on body or liver condition indices. Exposure to the tank mix resulted in lethargy during exposure and a 1-d delay in completion of metamorphosis. Deformities present in the rearing population confounded results for some endpoints. Observed effects were minimal, especially compared with the potential for ecological impacts from unmanaged invasive plants. Environ Toxicol Chem 2017;36:2316–2326. © 2017 SETAC
Psychotherapy Utilization and Retention in a National Sample of Veterans With PTSD
Authors: Doran Jennifer M. , Pietrzak Robert H. , Hoff Rani , Harpaz‐Rotem Ilan 
Published: February 2017

ObjectiveThis study examines the demographic, diagnostic, and military variables associated with psychotherapy utilization and retention in a national Veteran sample.MethodA large administrative VA dataset (142,620 Veterans) was utilized. Logistic regression was used to determine predictors of psychotherapy utilization and retention.ResultsFemale gender was associat ed with increased psychotherapy utilization and retention. Geriatric age was associated with less retention in individual psychotherapy. Being a racial minority was associated with decreased utilization, but increased retention in group therapy. The majority of comorbid diagnoses were associated with longer retention in treatment. Depression was associated with decreased utilization but longer treatment duration. Dimensional symptom assessment demonstrated relationships with the dependent variables. Avoidance symptoms did not emerge as a barrier to treatment.ConclusionDifferences in psychotherapy utilization and retention emerged across demographic, diagnostic and military variables, suggesting that these variables should inform outreach and treatment retention efforts for Veterans with PTSD.
Effect of pH control on the anaerobic H‐B‐E fermentation of syngas in bioreactors
Authors: Fernández‐Naveira Ánxela , Veiga María C , Kennes Christian 
Published: February 2017

AbstractBACKGROUNDSyngas and some waste gases are composed mainly of carbon monoxide, carbon dioxide and hydrogen, which can be used by some acetogenic bacteria to produce ethanol, butanol or hexanol, and represents an attractive alternative to the conventional ABE (acetone–butanol–ethanol) fermentation. Experiments were carried out in bioreactors under different conditions (pH 5.75 and 4.75) with continuous supply of a mixture of CO/CO2/H2/N2 converted by Clostridium carboxidivorans into hexanol, butanol and ethanol (H‐B‐E fermentation).RESULTSApplying different pH control strategies will affect the syngas fermentation pattern, among others in terms of bioconversion rates as well as final concentrations of acids and alcohols. The highest concentrations of alcohols were obtained at pH 5.75, i.e. 2.7 g L−1 ethanol, 1.9 g L−1 butanol and 0.85 g L−1 hexanol, whereas the maximum production rates were observed at pH 4.75, reaching 0.048 g‐ethanol h−1 g−1‐biomass, 0.037 g‐butanol h−1 g−1‐biomass, and 0.026 g‐hexanol h−1 g−1‐biomass. However, a low pH negatively affects growth and acids production in the first metabolic step, with lower growth and acids production at pH 4.75 than 5.75. Growth rates reached 0.0057 h−1 and 0.072 h−1, respectively, at pH 4.75 and 5.75.CONCLUSIONSMaintaining initially a higher pH of 5.75 allows accumulating higher concentrations of acids than when natural acidification takes place. Such higher concentrations of acids allow the production of higher amounts of alcohols as end metabolites, showing the importance of pH on bioconversion and biomass growth. © 2017 Society of Chemical Industry
Symptomatic pelvic accessory spleen in a female adolescent: Case report
Authors: Tendler Rene , Farah Rola Khamise , Kais Mohamad , Odeh Marwan , Bornstein Jacob 
Published: February 2017

ABSTRACTAccessory spleens are congenital foci of healthy splenic tissue that are separate from the main body of the spleen. They occur in 10–30% of individuals; a wandering accessory spleen located in the pelvis is uncommon. Most patients are asymptomatic. We describe the case of a female adolescent presenting with acute abdominal pain who had a pelvic accessory spleen that mimicked an adnexal mass. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 45:600–602, 2017
Bone robusticity in two distinct skeletal dysplasias diverges from established patterns
Authors: Citron Kate , Veneziale Cosmo , Marino Josephine , Carter Erin M. , Jepsen Karl J. , Raggio Cathleen 
Published: February 2017

ABSTRACTAchondroplasia (ACH) is a heritable disorder of endochondral bone formation characterized by disproportionate short stature. Osteogenesis imperfecta (OI) is a heritable bone and connective tissue disorder characterized by bone fragility. To investigate bone morphology of these groups, we retrospectively reviewed 169 de‐identified bone age films from 20 individuals with ACH, 39 individuals with OI and 37 age‐ and sex‐matched controls (matched to historical measurements from the Bolton–Brush Collection). We calculated robustness (Tt.Ar/Le) and relative cortical area (Ct.Ar/Tt.Ar) from measurements of the second metacarpal, which reflect overall bone health. Relative cortical area (RCA) is a significant predictor of fracture risk and correlates with robustness at other sites. Individuals with OI had RCH values above and robustness values below that of the control population. Bisphosphonate treatment did not significantly impact either robustness or RCA. In contrast to that reported in the unaffected population, there was no sexual dimorphism found in OI robustness or relative cortical area. We suggest that the underlying collagen abnormalities in OI override sex‐specific effects. Individuals with ACH had robustness values above and RCA values below that of the control population. Sexual dimorphism was found in ACH robustness and RCH values. Clinical significance: Identifies morphologic trends in two distinct skeletal dysplasia populations (OI and ACH) to better understand development of bone robusticity and slenderness in humans. Understanding these patterns of bone morphology is important to predict how individuals will respond to treatment and to increase treatment effect. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2392–2396, 2017.
Rapid quantification of total protein with surface‐enhanced Raman spectroscopy using o‐phthalaldehyde
Authors: Eryilmaz Merve , Zengin Adem , Boyaci Ismail Hakki , Tamer Uğur 
Published: February 2017

In this study, surface‐enhanced Raman spectroscopy (SERS) based quantification method for the total protein using o‐phthalaldehyde is reported for the first time. For this purpose, o‐phthalaldehyde was chosen to form a complex with protein, and SERS signal was observed in the presence of gold nanoparticles. A calibration curve was obtained by plotting the intensity of the SERS signal at 727 cm−1 versus the concentration of protein standard (bovine serum albumin, BSA). Thus, the correlation was found to be linear within the range of 0.054–0.72 mg/ml of BSA, and the limit of detection was determined to be 0.08 mg/ml. All tests were carried out using a portable Raman instrument with an analysis time of 5 min. In addition, the ability of the developed method to quantify total protein in milk samples was investigated, and the obtained results were compared to the conventional ultraviolet methods. Copyright © 2017 John Wiley & Sons, Ltd.
In‐situRaman study of phengite compressed in water medium under simultaneously highP–Tparameters
Authors: Goryainov S. V. , Krylov A. S. , Polyansky O. P. , Vtyurin A. N. 
Published: February 2017

Thein‐situmethod of Raman spectroscopy was used to study the layered mineral phengite, K(Al,Mg)2(Si,Al)4O10(OH)2, compressed in water under simultaneously high temperatures and pressures (respectively, up to 373 °С and 12.5 GPa). The implemented conditions were typical of modeling the ‘cold’ subduction zones in lithospheric slabs. The high pressures and temperatures were produced in an electrically heated diamond‐anvil cell. Measured Raman spectra have demonstrated a highР–Тstability of the mineral. No non‐quenchable phengite states (no reversible or irreversible polymorphic transitions, overhydration or notable amorphization) were observed in the investigated samples. Copyright © 2017 John Wiley & Sons, Ltd.
Titanium doping of BiFeO3 ceramics and identification of minor phases by Raman spectroscopy
Authors: Bernardo M. S. , Calatayud D. G. , Jardiel T. , Makovec D. , Peiteado M. , Caballero A. C. 
Published: February 2017

Titanium substitution can improve the multiferroic properties of bismuth ferrite materials, albeit the structural changes that this dopant produces in the perovskite structure of BiFeO3 are still not well understood. Due to its high sensitivity, Raman spectroscopy can be a useful tool for trailing the dopant incorporation. In this work, we study the Raman spectra of undoped and Ti4+‐doped BiFeO3 ceramics that also contain small amounts of secondary phases – as it is usual for materials of this system. The micro‐Raman study together with a rigorous derivative analysis of the experimental Raman spectra recorded at low temperature (73 K) enables, for the first time, the identification of the Raman bands associated with the BiFeO3 phase together with those belonging to the minor secondary phases. The comparison between the Raman spectra of the undoped and the Ti4+‐doped materials indicates that some of the titanium added to the composition interacts with the secondary phases while only a partial amount of this dopant actually incorporates into the BiFeO3 phase. Copyright © 2017 John Wiley & Sons, Ltd.
Raman spectroscopy of various phosphate minerals and occurrence of tuite in the Elga IIE iron meteorite
Authors: Litasov Konstantin D. , Podgornykh Nikolay M. 
Published: February 2017

The Raman spectra of phosphate minerals: apatite, merrillite, panethite, brianite, czochralskiite, maricite, new phosphate with composition of Na2Fe(Mg,Ca)(PO4)2 and high‐pressure phase tuite from the Elga IIE iron meteorite are characterized. Panethite, brianite, czochralskiite and new Na‐Fe phosphate were described for the first time. The basic features of all studied phosphates include strong ν1 symmetric stretching mode of PO43− ions at 950–990 cm−1, antisymmetric ν3 vibrations in the 1000–1175 cm−1 region and weak bands in the 400–500 cm−1 region, which correspond to ν2 bending mode and in the 550–640 cm−1 region, related to ν4 bending mode. Weak bands at less than 300 cm−1 represent lattice modes. Most of the studied phosphates have three non‐equivalent positions of phosphorus atoms in the crystal structures and can be derived from glaserite, K3Na(SO4)2, arrangement. Two or three of non‐equivalent [PO4] tetrahedra typically correspond to two or three strong bands in the region of ν1 vibrations. High‐pressure mineral tuite has similar composition and was formed after merrillite. P‐O vibrations in equivalent [PO4] tetrahedra produce major Raman band of tuite at 972 cm−1. The Elga parent‐body experienced a shock pressure of at least 12–15 GPa according to minimum pressures of tuite formation in the static high‐pressure experiments. This is the first finding of tuite in iron meteorites and the only second finding of high‐pressure mineral in them. Copyright © 2017 John Wiley & Sons, Ltd.
Cascade convolutional neural networks for automatic detection of thyroid nodules in ultrasound images
Authors: Ma Jinlian , Wu Fa , Jiang Tian'an , Zhu Jiang , Kong Dexing 
Published: February 2017

PurposeIt is very important for calculation of clinical indices and diagnosis to detect thyroid nodules from ultrasound images. However, this task is a challenge mainly due to heterogeneous thyroid nodules with distinct components are similar to background in ultrasound images. In this study, we employ cascade deep convolutional neural networks (CNNs) to develop and evaluate a fully automatic detection of thyroid nodules from 2D ultrasound images.MethodsOur cascade CNNs are a type of hybrid model, consisting of two different CNNs and a new splitting method. Specifically, it employs a deep CNN to learn the segmentation probability maps from the ground true data. Then, all the segmentation probability maps are split into different connected regions by the splitting method. Finally, another deep CNN is used to automatically detect the thyroid nodules from ultrasound thyroid images.ResultsExperiment results illustrate the cascade CNNs are very effective in detection of thyroid nodules. Specially, the value of area under the curve of receiver operating characteristic is 98.51%. The Free‐response receiver operating characteristic (FROC) and jackknife alternative FROC (JAFROC) analyses show a significant improvement in the performance of our cascade CNNs compared to that of other methods. The multi‐view strategy can improve the performance of cascade CNNs. Moreover, our special splitting method can effectively separate different connected regions so that the second CNN can correctively gain the positive and negative samples according to the automatic labels.ConclusionsThe experiment results demonstrate the potential clinical applications of this proposed method. This technique can offer physicians an objective second opinion, and reduce their heavy workload so as to avoid misdiagnosis causes because of excessive fatigue. In addition, it is easy and reproducible for a person without medical expertise to diagnose thyroid nodules.
Interchangeable neck shape–specific coils for a clinically realizable anterior neck phased array system
Authors: Beck Michael J. , Parker Dennis L. , Bolster Bradley D. , Kim Seong‐Eun , McNally J. Scott , Treiman Gerald S. , Hadley J. Rock 
Published: February 2017

PurposeTo demonstrate the interchangeable neck shape–specific (NSS) coil concept that supplements standard commercial spine and head/neck coils to provide simultaneous high‐resolution (hi‐res) head/neck imaging with high signal‐to‐noise ratio (SNR).MethodsTwo NSS coils were constructed on formers designed to fit two different neck shapes. A 7‐channel (7ch) ladder array was constructed on a medium neck former, and a 9‐channel (9ch) ladder array was constructed on large neck former. Both coils were interchangeable with the same preamp housing.ResultsThe 7ch and 9ch coils demonstrate SNR gains of approximately 4 times and 3 times over the Siemens 20‐channel head/neck coil in the carotid arteries of our volunteers, respectively. Coupling between the Siemens 32‐channel spine coil, Siemens 20‐channel head/neck coil, and the NSS coils was negligible, allowing for simultaneous hi‐res head/neck imaging with high SNR.ConclusionsThis study demonstrates that supplementing existing commercial spine and head/neck coils with an NSS coil allows uniform simultaneous hi‐res imaging with high SNR in the anterior neck, while maintaining SNR of the commercial coil in the head and posterior neck. Magn Reson Med 78:2460–2468, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
Detection of fasciculations in amyotrophic lateral sclerosis: The optimal ultrasound scan time
Authors: Noto Yu‐ichi , Shibuya Kazumoto , Shahrizaila Nortina , Huynh William , Matamala José M. , Dharmadasa Thanuja , Kiernan Matthew C. 
Published: February 2017

ABSTRACTIntroductionThis study seeks to elucidate the optimal scan time to detect fasciculations by using ultrasound in the diagnosis of amyotrophic lateral sclerosis (ALS).MethodsThe intervals between fasciculations were recorded from tongue, abdominal, and limb muscles in ALS patients, incorporating assessment of the cumulative probability of 2 fasciculations occurring.ResultsFrom prospective studies of 228 muscles from 19 ALS patients, fasciculations were detectable in 68% of patients. The longest interfasciculation interval recorded was 81.4 s in the hand muscle. The cumulative probability of 2 fasciculations occurring was calculated as ≥0.9 in all muscles during a period of 60 s.DiscussionA definition of 2 or more fasciculations occurring during a scan time of 60 s reliably allowed detection of fasciculations in ALS. Muscle Nerve, 2017
Dynamic response of a pile considering the interaction of pile variable cross section with the surrounding layered soil
Authors: Gao Liu , Wang Kuihua , Xiao Si , Wu Wenbing 
Published: February 2017

SummaryAssuming that the pile variable cross section interacts with the surrounding soil in the same way as the pile toe does with the bearing stratus, the interaction of pile variable cross section with the surrounding soil is represented by a Voigt model, which consists of a spring and a damper connected in parallel, and the spring constant and damper coefficient are derived. Thus, a more rigid pile–soil interaction model is proposed. The surrounding soil layers are modeled as axisymmetric continuum in which its vertical displacements are taken into account and the pile is assumed to be a Rayleigh–Love rod with material damping. Allowing for soil properties and pile defects, the pile–soil system is divided into several layers. By means of Laplace transform, the governing equations of soil layers are solved in frequency domain, and a new relationship linking the impedance functions at the variable‐section interface between the adjacent pile segments is derived using a Heaviside step function, which is called amended impedance function transfer method. On this basis, the impedance function at pile top is derived by amended impedance function transfer method proposed in this paper. Then, the velocity response at pile top can be obtained by means of inverse Fourier transform and convolution theorem. The effects of pile–soil system parameters are studied, and some conclusions are proposed. Then, an engineering example is given to confirm the rationality of the solution proposed in this paper. Copyright © 2017 John Wiley & Sons, Ltd.
Beta‐3 adrenergic receptor is expressed in acetylcholine‐containing nerve fibers of the human urinary bladder: An immunohistochemical study
Authors: Coelho Ana , Antunes‐Lopes Tiago , Gillespie James , Cruz Francisco 
Published: February 2017

AIMSTo identify in the human bladder the structures which express the Beta‐3 adrenoceptor (β3AR).METHODSHuman bladders from cadaveric organ donors (equally balanced in sex and age) were collected. Bladders were immediately fixed in paraformaldehyde and further processed for cryostat sectioning. Single and double immunohistochemistry was performed using antibodies against β3AR C‐terminal, β3AR N‐terminal, a pan‐neuronal marker (β3‐Tubulin) and markers of cholinergic (Vesicular Acetylcholine Transporter), adrenergic (Tyrosine Hidroxylase), and peptidergic (Calcitonin Gene‐Related Peptide) nerve fibers.RESULTSNerve fibers expressing immunoreactivity for β3AR were abundantly found in the mucosa and muscular layers of the human bladder. No β3AR‐IR was detected on urothelial or smooth muscle cells. The presence of β3AR‐IR in nerve fibers was confirmed by co‐expression with β3‐Tubulin. Nerve fibers expressing β3AR‐IR were cholinergic, VAChT+, and abundantly observed in the suburothelium. The cholinergic fibers were in close proximity and intermingled with adrenergic TH+ and peptidergic CGRP+ fibers.CONCLUSIONSWe demonstrated that β3AR is abundantly located in acetylcholine‐containing nerve fibers. These findings have important consequences to understand the mechanism of action of β3AR agonists currently used for the treatment of OAB.