bluuebunny/crossref_metadata_2025_split huggingface dataset:
Layered Ni(OH)2-Co(OH)2 films prepared by electrodeposition as charge storage electrodes for hybrid supercapacitors
Authors: Nguyen Tuyen , Boudard Michel , Carmezim M. João , Montemor M. Fátima 
Published: January 2017

AbstractConsecutive layers of Ni(OH)2 and Co(OH)2 were electrodeposited on stainless steel current collectors for preparing charge storage electrodes of high specific capacity with potential application in hybrid supercapacitors. Different electrodes were prepared consisting on films of Ni(OH)2, Co(OH)2, Ni1/2Co1/2(OH)2 and layered films of Ni(OH)2 on Co(OH)2 and Co(OH)2 on Ni(OH)2 to highlight the advantages of the new architecture. The microscopy studies revealed the formation of nanosheets in the Co(OH)2 films and of particles agglomerates in the Ni(OH)2 films. Important morphological changes were observed in the double hydroxides films and layered films. Film growth by electrodeposition was governed by instantaneous nucleation mechanism. The new architecture composed of Ni(OH)2 on Co(OH)2 displayed a redox response characterized by the presence of two peaks in the cyclic voltammograms, arising from redox reactions of the metallic species present in the layered film. These electrodes revealed a specific capacity of 762 C g−1 at the specific current of 1 A g−1. The hybrid cell using Ni(OH)2 on Co(OH)2 as positive electrode and carbon nanofoam paper as negative electrode display specific energies of 101.3 W h g−1 and 37.8 W h g−1 at specific powers of 0.2 W g−1 and 2.45 W g−1, respectively.
Progressive induction of hepatocyte progenitor cells in chronically injured liver
Authors: Tanimizu Naoki , Ichinohe Norihisa , Yamamoto Masahiro , Akiyama Haruhiko , Nishikawa Yuji , Mitaka Toshihiro 
Published: January 2017

AbstractDifferentiated epithelial cells show substantial lineage plasticity upon severe tissue injuries. In chronically injured mouse livers, part of hepatocytes become Sry-HMG box containing 9 (Sox9) (+) epithelial cell adhesion molecule (−) hepatocyte nuclear factor 4 α (+) biphenotypic hepatocytes. However, it is not clear whether all Sox9+ hepatocytes uniformly possess cellular properties as hepatocyte progenitors. Here, we examined the microarray data comparing Sox9+ hepatocytes with mature hepatocytes and identified CD24 as a novel marker for biphenotypic hepatocytes. Immunohistochemical analyses showed that part of Sox9+ hepatocytes near expanded ductular structures expressed CD24 in the liver injured by 3,5-diethoxycarbonyl-1,4-dihydro-collidine (DDC) diet and by bile duct ligation. Indeed, Sox9+ hepatocytes could be separated into CD24− and CD24+ cells by fluorescence activated cell sorting. The ratio of CD24+ cells against CD24− ones in Sox9+ hepatocytes gradually increased while DDC-injury progressed and colony-forming capability mostly attributed to CD24+ cells. Although hepatocyte markers were remarkably downregulated in of Sox9+ CD24+ hepatocytes, they re-differentiated into mature hepatocytes in vitro and in vivo. Our current results demonstrate that the emergence of biphenotypic hepatocytes is a sequential event including the transition from CD24− and CD24+ status, which may be a crucial step for hepatocytes to acquire progenitor properties.
Prostate Cancer Mortality-To-Incidence Ratios Are Associated with Cancer Care Disparities in 35 Countries
Authors: Chen Sung-Lang , Wang Shao-Chuan , Ho Cheng-Ju , Kao Yu-Lin , Hsieh Tzuo-Yi , Chen Wen-Jung , Chen Chih-Jung , Wu Pei-Ru , Ko Jiunn-Liang , Lee Huei , Sung Wen-Wei 
Published: January 2017

AbstractThe variation in mortality-to-incidence ratios (MIRs) among countries reflects the clinical outcomes and the available interventions for colorectal cancer treatments. The association between MIR of prostate cancer and cancer care disparities among countries is an interesting issue that is rarely investigated. For the present study, cancer incidence and mortality rates were obtained from the GLOBOCAN 2012 database. The rankings and total expenditures on health of various countries were obtained from the World Health Organization (WHO). The association between variables was analyzed by linear regression analyses. In this study, we estimated the role of MIRs from 35 countries that had a prostate cancer incidence greater than 5,000 cases per year. As expected, high prostate cancer incidence and mortality rates were observed in more developed regions, such as Europe and the Americas. However, the MIRs were 2.5 times higher in the less developed regions. Regarding the association between MIR and cancer care disparities, countries with good WHO ranking and high total expenditures on health/gross domestic product (GDP) were significant correlated with low MIR. The MIR variation for prostate cancer correlates with cancer care disparities among countries further support the role of cancer care disparities in clinical outcome.
Serum uric acid levels are associated with obesity but not cardio-cerebrovascular events in Chinese inpatients with type 2 diabetes
Authors: Chen Ming-Yun , Zhao Cui-Chun , Li Ting-Ting , Zhu Yue , Yu Tian-Pei , Bao Yu-Qian , Li Lian-Xi , Jia Wei-Ping 
Published: January 2017

AbstractWe aim to explore the associations between serum uric acid (SUA) and obesity and cardio-cerebrovascular events (CCEs) in Chinese inpatients with type 2 diabetes mellitus (T2DM). 2 962 inpatients with T2DM were stratified into quartile based on SUA concentrations. There were significant increases in the prevalence of both obesity (32.6%, 41.9%, 50.1%, and 62.8%, respectively, p < 0.001 for trend) and severe obesity (0.4%, 0.6%, 0.8%, and 1.3%, respectively, p < 0.001 for trend) across the SUA quartiles. A fully adjusted multiple logistic regression analysis revealed that SUA quartiles were independently associated with the presence of obesity (p < 0.001). The prevalence of CCEs was significantly higher in the obese diabetics than in the nonobese diabetics (16.8% vs. 13.2%, p = 0.027). After controlling for multiple confounding factors, BMI levels were also significantly correlated with the presence of CCEs (p = 0.020). However, there was no significant association of SUA quartiles/SUA levels with the presence of CCEs in T2DM. This study suggested that SUA levels were independently associated with obesity but not with CCEs in patients with T2DM. In selected populations such as subjects with T2DM, the role of uric acid in cardiovascular complications might be attributable to other cardiovascular risk factors, such as obesity.
Predictive Value of Serum IFN-γ inducible Protein-10 and IFN-γ/IL-4 Ratio for Liver Fibrosis Progression in CHB Patients
Authors: Wang Yadong , Yu Weiyan , Shen Chuan , Wang Wei , Zhang Li , Liu Fang , Sun Hui , Zhao Yajuan , Che Honghao , Zhao Caiyan 
Published: January 2017

AbstractNoninvasive serum markers for assessment of liver fibrosis in chronic hepatitis B (CHB) patients have not been well-studied. The present study was to evaluate the predictive value of serum interferon gamma-inducible protein-10 (IP-10/CXCL10) and the interferon (IFN)-γ/interleukin (IL)-4 ratio for liver fibrosis progression in CHB patients. A total of 180 CHB patients were categorized into four groups: no fibrosis, mild fibrosis, moderate fibrosis, and severe fibrosis. Serum and intrahepatic levels of IP-10, IFN-γ, and IL-4 were examined, from which the IFN-γ/IL-4 ratio was calculated. We found that the serum IP-10 levels were positively correlated with the severity of liver fibrosis, whereas the IFN-γ/IL-4 ratio was negatively associated with the progression of hepatic fibrosis. Multivariate logistic regression analysis revealed that the serum IP-10 was an independent predictor for significant fibrosis. For predicting significant fibrosis, the IP-10 cut-off value of 300 ng/mL had a sensitivity of 92.7% and a specificity of 68.6%. When the IP-10 level was combined with the IFN-γ/IL-4 ratio, the specificity and positive predictive value were 93.8% and 94.6%, respectively; thus, the discriminatory ability was much improved. In conclusion, the serum IP-10 level and the IFN-γ/IL-4 ratio have great potential to predict significant fibrosis among CHB patients.
GLP-1 analogue-induced weight loss does not improve obesity-induced AT dysfunction
Authors: Pastel Emilie , McCulloch Laura J. , Ward Rebecca , Joshi Shivam , Gooding Kim M. , Shore Angela C. , Kos Katarina 
Published: January 2017

Glucagon-like peptide-1 (GLP-1) analogues aid weight loss that improves obesity-associated adipose tissue (AT) dysfunction. GLP-1 treatment may however also directly influence AT that expresses the GLP-1 receptor (GLP-1R). The present study aimed to assess the impact of GLP-1 analogue treatment on subcutaneous AT (SCAT) inflammatory and fibrotic responses, compared with weight loss by calorie reduction (control). Among the 39 participants with Type 2 diabetes recruited, 30 age-matched participants were randomized to 4 months treatment with Liraglutide (n=22) or calorie restriction based on dietetic counselling (n=8). Assessments included clinical characteristics and repeated subcutaneous abdominal AT biopsies. Liraglutide resulted in weight loss in most participants (−3.12±1.72 kg, P=0.007) and significant reduction in visceral AT (VAT). It was more effective in lowering fasting glucose, in comparison with weight loss by dieting. However, tumour necrosis factor-α (TNFA) AT-expression (P=0.0005), macrophage chemoattractant protein-1 (MCP-1) expression (P=0.027) and its serum levels (P=0.048) increased with Liraglutide, suggestive of an inflammatory response unlike in the diet arm in which a trend of lower cluster of differentiation 14 (CD14) expression (P=0.09) was found. Liraglutide treatment also increased expression of factors involved in extracellular matrix (ECM) deposition, transforming growth factor-β (TGFB) and collagen type 1 alpha 1 chain (COL1A1) (TGFB1: before 0.73±0.09 arbitrary units (AU), after 1.00±0.13 AU, P=0.006; COL1A1: 0.84±0.09 AU compared with 1.49±0.26 AU, P=0.026). Liraglutide thus appears to induce an inflammatory response in AT and influences ECM remodelling. Despite its superior effect on glycaemia, Liraglutide does not improve obesity-associated AT dysfunction in subcutaneous tissue. It is yet unclear whether this limits AT storage capacity for lipids. This may be of importance in patients being re-exposed to positive energy balance such as post GLP-1 discontinuation.
Einsatz einer Unterkiefer-Protrusionsschiene zur Behandlung von obstruktiver Schlafapnoe
Authors: Metaxas E. , Nicolaou Z. , Laspos C. 
Published: January 2017

ZusammenfassungDas obstruktive Schlafapnoesyndrom (OSAS) ist eine häufig auftretende Erkrankung, die mit einer erhöhten Morbidität und Mortalität einhergeht. Es entsteht aufgrund einer Obstruktion des Nasopharynx, die zu einer Hypoxie führt. Die gängigste Behandlungsmethode von OSA besteht in der Verwendung von CPAP-Geräten (Continuous Positive Airway Pressure). Eine weitere Therapiemöglichkeit ist der Einsatz von mandibulären Protrusionsschienen (MADs), durch die der anteroposteriore Durchmesser des Rachens vergrößert und damit die Atmung erleichtert wird, was eine Atemwegsobstruktion verhindert. Die Daten für diesen Bericht wurden durch Beobachtung von 12 Patienten mit OSA erhoben. Bei 10 der 12 Patienten konnte eine signifikante Verbesserung sowohl des Apnoe-Hypopnoe-Index (AHI) als auch der Symptomatik festgestellt werden. Gemäß der Literatur sind Komplikationen durch die Verwendung von MADs zu erwarten. Die Mehrzahl der Patienten berichtete über vermehrte Sialorrhö in den ersten 2–3 Tagen der Therapie sowie über eine vorübergehende Schleimhautreizung. Trotz der bei einigen Patienten beobachteten leichten Komplikationen infolge der Verwendung des Geräts zeigt diese Studie, dass der Einsatz von MADs eine einfache, wirtschaftliche und effektive Möglichkeit zur Behandlung von Menschen mit OSA darstellt.
Global urban signatures of phenotypic change in animal and plant populations
Authors: Alberti Marina , Correa Cristian , Marzluff John M. , Hendry Andrew P. , Palkovacs Eric P. , Gotanda Kiyoko M. , Hunt Victoria M. , Apgar Travis M. , Zhou Yuyu 
Published: January 2017

Significance
Ecoevolutionary feedbacks on contemporary timescales were hypothesized over half a century ago, but only recently has evidence begun to emerge. The role that human activity plays in such dynamics is still unclear. Through a metaanalysis of >1,600 phenotypic changes in species across regions and ecosystem types, we examine the evidence that the rate of phenotypic change has an urban signature. Our findings indicate greater phenotypic change in urbanizing systems compared with natural and nonurban anthropogenic systems. By explicitly linking urban development to trait changes that might affect ecosystem function, we provide insights into the potential ecoevolutionary implications for maintaining ecosystem function and the sustainability of human well-being.
Antibiotic stress selects against cooperation in the pathogenic bacterium
Pseudomonas aeruginosa
Authors: Vasse Marie , Noble Robert J. , Akhmetzhanov Andrei R. , Torres-Barceló Clara , Gurney James , Benateau Simon , Gougat-Barbera Claire , Kaltz Oliver , Hochberg Michael E. 
Published: January 2017

Significance
The evolution of cooperation is a central issue in biology and the social sciences. Study of model systems of social microbes has focused on how “cooperators” and “cheats” interact but rarely accounts for the surrounding environment. We demonstrate how environmental stress in the form of antibiotics alters the evolution of public goods cooperation in a bacterium. Antibiotics accentuate the costs to cooperators, resulting in their rapid demise relative to cheats. In a more applied vein, antibiotic resistance was maximal in the presence of both producers and cheats, suggesting that knowledge about social strategies can be used to improve therapies. Our work emphasizes ecoevolutionary feedback in social evolution and demonstrates that social interactions may be considerably modified in natural, stressful environments.
Dinosaur incubation periods directly determined from growth-line counts in embryonic teeth show reptilian-grade development
Authors: Erickson Gregory M. , Zelenitsky Darla K. , Kay David Ian , Norell Mark A. 
Published: January 2017

SignificanceLittle is known regarding nonavian dinosaur embryology. Embryological period relates to myriad aspects of development, life history, and evolution. In reptiles incubation is slow, whereas in birds it is remarkably rapid. Because birds are living dinosaurs, rapid incubation has been assumed for all dinosaurs. We discovered daily forming growth lines in teeth of embryonic nonavian dinosaurs revealing incubation times. These lines show slow reptilian-grade development spanning months. The rapid avian condition likely evolved within birds prior to the Cretaceous–Paleogene (K–Pg) mass extinction event. Prolonged incubation exposed nonavian dinosaur eggs and attending parents to destructive influences for long periods. Slow development may have affected their ability to compete with more rapidly generating populations of birds, reptiles, and mammals following the K–Pg cataclysm.
Ancient human disturbances may be skewing our understanding of Amazonian forests
Authors: McMichael Crystal N. H. , Matthews-Bird Frazer , Farfan-Rios William , Feeley Kenneth J. 
Published: January 2017

Significance
The Amazon harbors thousands of species and plays a vital role in the Earth’s climate and carbon cycles. Much of what we know about the Amazon is based on censuses of only a small number of forest inventory plots, an even smaller number of which are censused repeatedly and used to study forest dynamics and carbon fluxes. The effects of ancient human impacts have never been properly assessed or accounted for in studies of Amazonian plots. New spatial analyses show that plots significantly oversample areas with high abundances of archaeological evidence of past human activities. This suggests that our interpretations of the Amazon’s structure, composition, and function are based disproportionately on forests still reflecting the legacies of past human disturbances.
Genetic stability of genome-scale deoptimized RNA virus vaccine candidates under selective pressure
Authors: Le Nouën Cyril , McCarty Thomas , Brown Michael , Smith Melissa Laird , Lleras Roberto , Dolan Michael A. , Mehedi Masfique , Yang Lijuan , Luongo Cindy , Liang Bo , Munir Shirin , DiNapoli Joshua M. , Mueller Steffen , Wimmer Eckard , Collins Peter L. , Buchholz Ursula J. 
Published: January 2017

Significance
Recoding viral genomes by numerous synonymous substitutions provided live attenuated vaccine candidates predicted to have a low risk of reversion. However, their stability under selective pressure was largely unknown. We evaluated the phenotypic reversion of representative genome-scale deoptimized human respiratory syncytial virus (RSV) vaccine candidates in the context of strong selective pressure. We found that a virus bearing a deoptimized L-polymerase ORF evolved to escape temperature sensitivity restriction by mutations in L and multiple other proteins. Additional analysis revealed that single mutations in the M2-1 ORF were able to substantially escape the restriction imposed by the deoptimized polymerase. Based on this information, we generated a stable deoptimized RSV vaccine candidate with improved attenuation and immunogenicity suitable for additional development.
Convergence liberalism and the problem of disagreement concerning public justification
Authors: Billingham Paul 
Published: January 2017

AbstractThe ‘convergence conception’ of political liberalism has become increasingly popular in recent years. Steven Wall has shown that convergence liberals face a serious dilemma in responding to disagreement about whether laws are publicly justified. What I call the ‘conjunctive approach’ to such disagreement threatens anarchism, while the ‘non-conjunctive’ approach appears to render convergence liberalism internally inconsistent. This paper defends the non-conjunctive approach, which holds that the correct view of public justification should be followed even if some citizens do not consider enacted laws to be publicly justified. My argument sheds light on the fundamental structure of convergence liberalism.
Development of immersion vaccine for bacterial cold-water disease in ayu Plecoglossus altivelis
Authors: Nakayama Hitoshi , Mori Mariko , Takita Teisuke , Yasukawa Kiyoshi , Tanaka Keisuke , Hattori Shunji , Aikawa Hideaki , Hasegawa Osamu , Okamura Takashi , Takegami Kentarou , Motokawa Shogo , Kuwahara Masakazu , Amano Kenichi 
Published: January 2017

Abstract
Flavobacterium psychrophilum (F. psychrophilum) is the causative agent of bacterial cold-water disease (BCWD) that occurs in ayu Plecoglossus altivelis. Formalin-killed cell of F. psychrophilum has long been studied as an immersion vaccine for BCWD. In this study, we explored the possibility of F. psychrophilum collagenase (fpcol) for use as the immersion vaccine. BCWD convalescent ayu sera contained specific IgM antibodies against somatic F. psychrophilum and fpcol, meaning that fpcol is a promising antigen for the vaccine development. The recombinant fpcol was successfully expressed in Escherichia coli and Brevibacillus chosinensis (B. chosinensis). The culture supernatant of the B. chosinensis was used as an immersion vaccine solution. The vaccinated ayu were then challenged by soaking into F. psychrophilum culture. In two experimental groups, the relative percentages of survivals were 63 and 38%, respectively, suggesting that fpcol is promising as the immersion vaccine for ayu-BCWD.
Immunocytochemical detection of rhamnogalacturonan II on forming cell plates in cultured tobacco cells
Authors: Zhou Ye , Awano Tatsuya , Kobayashi Masaru , Matoh Toru , Takabe Keiji 
Published: January 2017

Abstract
Rhamnogalacturonan II (RG-II) is a region of pectin macromolecules that is present in plant primary cell walls. The RG-II region serves as the site of borate cross-linking within pectin, via which pectin macromolecules link together to form a gel. In this study, we examined whether RG-II is present in the cell plate, the precursor of primary cell walls that forms during cytokinesis. A structure inside dividing cells was labeled with a rabbit polyclonal anti-RG-II antibody and detected by immunofluorescence microscopy. An antibody against callose, a marker polysaccharide for the cell plate, also labeled the structure. In immunoelectron microscopy analyses using the anti-RG-II antibody, gold particles were distributed in electron-lucent vesicular structures that appeared to correspond to the forming cell plates in late anaphase cells. Together, these results suggest that RG-II is present in cell plates from the early phase of their assembly.
Supplementary bilateral comparison of the national AC/DC voltage transfer references between VNIIM (Russia) and Ukrmetrteststandard (Ukraine) (COOMET.EM-S1)
Authors: Telitchenko G P 
Published: January 2017

This intercomparison was fulfilled in conformity with the agreed project of COOMET under ref. No 273-a/RU/03 at ELECTRICITY area. It is bilateral comparison between Ukrmetrteststandard (Ukraine) and VNIIM (Russia) (pilot laboratory). This project was arranged with an aim to establish degree of equivalence between Ukraine and Russia measurement standards and to confirm uncertainties declared by the participants. The results of the comparison will be used for confirmation calibration and measurement capabilities provided by Ukrmetrteststandard (Ukraine). VNIIM (Russia) (pilot laboratory) participated in CCEM-K6.a and has already presented their CMC in this area. The measurements had started in November 2004 and completed in February 2005

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The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).