bluuebunny/crossref_metadata_2025_split huggingface dataset:
The tension biology of wound healing
Authors: Harn Hans I‐Chen , Ogawa Rei , Hsu Chao‐Kai , Hughes Michael W. , Tang Ming‐Jer , Chuong Cheng‐Ming 
Published: November 2017

AbstractFollowing skin wounding, the healing outcome can be: regeneration, repair with normal scar tissue, repair with hypertrophic scar tissue or the formation of keloids. The role of chemical factors in wound healing has been extensively explored, and while there is evidence suggesting the role of mechanical forces, its influence is much less well defined. Here, we provide a brief review on the recent progress of the role of mechanical force in skin wound healing by comparing laboratory mice, African spiny mice, fetal wound healing and adult scar keloid formation. A comparison across different species may provide insight into key regulators. Interestingly, some findings suggest tension can induce an immune response, and this provides a new link between mechanical and chemical forces. Clinically, manipulating skin tension has been demonstrated to be effective for scar prevention and treatment, but not for tissue regeneration. Utilising this knowledge, specialists may modulate regulatory factors and develop therapeutic strategies to reduce scar formation and promote regeneration.
Up‐regulation of IL‐23 expression in human dental pulp fibroblasts by IL‐17 via activation of the NF‐κB and MAPK pathways
Authors: Wei L. , Liu M. , Xiong H. , Peng B. 
Published: November 2017

AbstractAimTo investigate the effects of the pro‐inflammatory and Th17‐polarizing mediator IL‐17 on HDPFs‐mediated IL‐23 production and the molecular mechanism involved.MethodologyInterleukin (IL)‐17R expression was determined by semi‐quantitative reverse transcriptase‐polymerase chain reaction and Western blot in cultured human dental pulp fibroblasts (HDPFs). Quantitative real‐time polymerase chain reaction and enzyme‐linked immunosorbent assay were used to determine IL‐23 mRNA and protein levels in IL‐17‐stimulated HDPFs, respectively. The nuclear factor‐kappa B (NF‐κB) and mitogen‐activated protein kinases (MAPKs) signalling pathways that mediate the IL‐17‐stimulated production of IL‐23 was investigated using Western blot and specific signalling inhibitor analyses. Statistical analyses were performed using Kruskal–Wallis tests followed by the Mann–Whitney U‐test. Statistical significance was considered when the P value < 0.05.ResultsPrimary HDPFs steadily expressed IL‐17R mRNA and surface‐bound protein. IL‐17 stimulated the expression of IL‐23 mRNA and protein in cultured human dental pulp fibroblasts, which was attenuated by IL‐17 or IL‐17R neutralizing antibodies. In accordance with the enhanced expression of IL‐23, IL‐17 stimulation resulted in rapid activation of p38 MAPK, extracellular signal‐regulated kinase (ERK) 1/2, c‐Jun‐N‐terminal kinase (JNK) and NF‐κB in HDPFs. Inhibitors of p38 MAPK, ERK 1/2 or NF‐κB significantly suppressed, whereas blocking JNK substantially augmented IL‐23 production from IL‐17‐stimulated HDPFs.ConclusionHDPFs expressed IL‐17R and responded to IL‐17 to produce IL‐23 via the activation of the NF‐κB and MAPK signalling pathways. The findings provide insights into the cellular mechanisms of the participation of IL‐17 in the activation of HDPFs in inflamed pulp tissue.
Association between killer cell immunoglobulin‐like receptor 2DS5 gene with essential hypertension in the Chinese Han patients
Authors: Wang A. L. , Jiang B. , Qian X. Y. , Zhang Q. , Peng H. , Zhang Y. H. 
Published: November 2017

SummaryHypertension has been suggested to be mediated by immunity and inflammation. As immune system genes, killer cell immunoglobulin‐like receptors (KIRs) genes play an important role in the pathogenesis of autoimmune diseases. We conducted a community population‐based case–control study to analyse associations between KIR genes and hypertension. KIR genes were genotyped using sequence‐specific primer polymerase chain reaction in 380 unrelated essential hypertensives and 527 normotensives. The frequencies of KIR2DS5 gene were significantly decreased in participants with high high‐sensitivity C‐reactive protein (hsCRP) compared with participants with low hsCRP (17.02% vs 34.08%, p = .016). The presence of KIR2DS5 gene was independently associated with decreased risk of hypertension (odds ratio = 0.62; 95% confidence interval: 0.43–0.89), after adjusted for conventional risk factors, hsCRP and other KIR genes. We found that participants with KIR2DS5 gene had a decreased risk of hypertension compared with participants without KIR2DS5 gene. Our findings suggested that KIR2DS5 gene may be protective against hypertension.
The impact of coronary artery disease and left ventricular ejection fraction on the prognosis of patients with peripheral artery disease
Authors: Tsujimura Takuya , Iida Osamu , Ishihara Takayuki , Fujita Masashi , Masuda Masaharu , Okamoto Shin , Nanto Kiyonori , Kanda Takashi , Sunaga Akihiro , Takahara Mitsuyoshi , Uematsu Masaaki 
Published: November 2017

AbstractThe impact of the severity of coronary artery disease (CAD) and left ventricular ejection fraction (LVEF) on the prognosis of patients with peripheral artery disease (PAD) has not been systematically studied. We retrospectively analysed 622 patients with PAD (intermittent claudication (IC): n = 446; critical limb ischaemia (CLI): n = 176). The association of SYNTAX score and LVEF with mortality was analysed using the Cox proportional hazard model. In patients with IC, a high SYNTAX score was significantly associated with mortality, whereas reduced LVEF was significantly associated with mortality in patients with CLI. The prognostic impact of CAD and LVEF appears different between patients with IC and CLI.
Orthodontic treatment simultaneous to or after periodontal cause‐related treatment in periodontitis susceptible patients. Part I: Clinical outcome. A randomized clinical trial
Authors: Zasčiurinskienė Eglė , Basevičienė Nomeda , Lindsten Rune , Slotte Christer , Jansson Henrik , Bjerklin Krister 
Published: November 2017

AbstractAimTo compare two treatment strategies regarding the effect of orthodontic treatment on periodontal status in patients with plaque‐induced periodontitis.Subjects and MethodsThis was a randomized clinical trial. Fifty periodontal patients were randomly assigned to the test or control groups according to periodontal treatment timing. All patients received supra‐ and subgingival debridement following baseline examination. Control group patients received cause‐related periodontal treatment before the start of orthodontic treatment and which was performed simultaneous to orthodontic treatment for the test group patients.ResultsNo difference between the test and control groups was found regarding change of clinical attachment level (CAL) after periodontal–orthodontic treatment. Fewer sites with initial pocket depth (PD) of 4–6 mm healed after periodontal–orthodontic treatment in the test group (20.5%, IQR = 11.9%) in comparison with controls (30.4%, IQR = 27.1%) (p = .03). Anterior teeth [OR 2.5] and teeth in male patients [OR 1.6] had a greater chance for PD improvement ≥2 mm. Total periodontal–orthodontic treatment duration was significantly longer for the control group (p < .01).ConclusionsBoth groups showed a gain of CAL and a reduction in sites with PD ≥ 4 mm. Orthodontic treatment, simultaneously to the periodontal treatment, could be used in the routine treatment of patients with plaque‐induced periodontitis.
Predation by polyphagous carabid beetles on eggs of a pest slug: Potential implications of climate change
Authors: El‐Danasoury H. , Iglesias‐Piñeiro J. 
Published: November 2017

AbstractHarpalus rufipesandPoecilus cupreusare two widespread polyphagous carabids which are known to destroy eggs of the pest slugDeroceras reticulatumin the laboratory. To examine the effect of temperature on the predation of the eggs ofD. reticulatumbyH. rufipesandP. cupreus, a laboratory experiment with different temperatures and a semi‐field experiment including simulated warming were performed. In both experiments,H. rufipeskilled more eggs thanP. cupreus,and the predatory activity of the former increased significantly with increasing temperature. To our knowledge, this is the first study on predatory activity of polyphagous carabids on the eggs of a pest slug performed under a climate warming scenario. Results suggest that biological pest control performed by polyphagous carabids such asH. rufipesupon pest slugs may be enhanced under predicted climate warming conditions.
Oral microbiome alterations of healthy volunteers with proton pump inhibitor
Authors: Mishiro Tsuyoshi , Oka Kentaro , Kuroki Yasutoshi , Takahashi Motomichi , Tatsumi Kasumi , Saitoh Tsukasa , Tobita Hiroshi , Ishimura Norihisa , Sato Shuichi , Ishihara Shunji , Sekine Joji , Wada Koichiro , Kinoshita Yoshikazu 
Published: November 2017

AbstractBackground and AimAcid suppressive agents including proton pump inhibitors (PPIs) are used as first‐line treatment for various acid‐related gastrointestinal disorders. Although known to profoundly reduce gastric acid production, their influence on inhibition of acid secretion as part of the function of the gastrointestinal tract microbiome remains to be elucidated. The aim of the present study was to examine the effects of PPI usage on oral and gut microbiota in healthy volunteers.MethodsTen healthy adult volunteers receiving no medications were enrolled. We obtained fecal, saliva, and periodontal pocket fluid samples from the subjects before and after 4 weeks of once daily administrations of 20‐mg esomeprazole. The effects of PPI administration on bacterial communities were investigated using a 16S rRNA gene sequencing method.ResultsSpecies richness (alpha diversity) was significantly different among the salivary, periodontal pocket, and fecal samples. Furthermore, the measurements for UniFrac distances, despite inter‐individual variations (beta diversity), of the microbiota structure of saliva and periodontal pocket and feces samples were clearly separated from each other. The salivary samples showed significant differences between alpha and beta diversity measurements before and after administration of the PPI for 4 weeks. Meanwhile, taxon‐based analysis indicated that PPI administration raised the ratio of Streptococcus organisms in fecal samples, suggesting a potentially unfavorable effect leading to gut microbiota alteration. Moreover, alterations of the microbiota in the oral carriage microbiome along with bacterial overgrowth (Streptococcus) and decreases in distinct bacterial species (Neisseria and Veillonella) were observed.ConclusionsThese results suggest that PPIs cause both oral and gut microbiota alterations.
The risk of non‐melanoma skin cancer in New Zealand in inflammatory bowel disease patients treated with thiopurines
Authors: Bahi Morwan , Walmsley Russell S , Gray Andrew R , Young David , Hobbs Catherine E , Aluzaite Kristina , Schultz Michael 
Published: November 2017

AbstractBackground and AimNew Zealand (NZ) has one of the highest rates of non‐melanoma skin cancers (NMSCs) in the world. Thiopurine use in inflammatory bowel disease (IBD) patients has been shown to increase NMSC risk. This study aimed to investigate the possible increase of NMSC risk in thiopurine‐treated IBD patients in NZ despite the high background rate.MethodsInflammatory bowel disease patients treated with thiopurines and healthy controls were recruited across two different latitude centers in NZ. Consented participants completed a questionnaire to identify additional risk factors and were examined for suspicious skin lesions. These were photographed, and the pictures were evaluated by a dermatologist. Data were compared between centers and between groups with NMSC incidence and thiopurine—associated relative risks estimated.ResultsOne hundred seventy‐one thiopurine‐exposed IBD patients and 201 controls were recruited. Twenty seven of 390 photographs (26 participants) showed suspicious lesions (17 exposed, 9 controls) as determined by the dermatologist. Estimated NMSC incidence was 24.7–34.3/1000 patient‐years (thiopurine‐exposed, depending on classification of unconfirmed suspicious lesions) and 7–14/1000 patient‐years (control). The relative risk of NMSC among thiopurine exposed was 2.38–2.97 (P ≤ 0.014), which remained significant after individually adjusting for potential confounders. We estimated the NMSC risk to increase 5.4–6.6% per 6 months of thiopurine use (P < 0.001). Low compliance in avoiding NMSC risk factors in the exposed group was observed.ConclusionsWe found a twofold to threefold increase in NMSC incidence in IBD patients treated with thiopurines in NZ, despite the high background incidence rate.
Do body build and composition influence striae distensae occurrence and visibility in women?
Authors: Kasielska‐Trojan Anna , Antoszewski Bogusław 
Published: November 2017

SummaryBackgroundStriae have been reported to be one of the most common skin changes and a commonly encountered esthetic problem.ObjectivesTo analyze risk factors of striae not associated with pregnancy and verify if body build and composition influence striae distensae (SD) occurrence and visibility.MethodsEighty female students (40 with striae (the mean age 23.9 years, SD 2.05 years) and 40 without these lesions (24.7 years, SD 6.2 years)) were included in the study. The subjects were asked to fill out a questionnaire including questions concerning risk factors of SD. Body build and composition were examined using Tanita SC‐331S Body Composition Analyzer.ResultsWomen without striae more often reported a history of intended weight loss (P < .0001), less frequently had a history of contraceptives intake (P < .001) and more often their family history of striae was negative or unknown (P = .01). Multivariate analysis including body build and composition parameters indicated BMI as risk factor of SD (P = .021; OR =1.155, 95% CI 1.006; 1.325).ConclusionsHistory of contraceptives intake and a family history of striae are risk factors of SD occurrence, while weight loss can reduce the risk of these lesions. BMI appeared to be the risk factor of striae visibility, especially in abdomen, but not on the buttocks. Further clinical researches are needed to examine the pathophysiology of this condition and to inform patients about the possibility to reduce the risk of striae occurrence.
Seedling and adult‐plant stage resistance of a world collection of barley genotypes to stripe rust
Authors: Gyawali Sanjaya , Verma Ramesh Pal Singh , Kumar Subodh , Bhardwaj Subhash Chand , Gangwar Om Prakash , Selvakumar Rajan , Shekhawat Pradip Singh , Rehman Sajid , Sharma‐Poudyal Dipak 
Published: November 2017

AbstractBarley stripe rust caused by Puccinia striiformis f.sp. hordei (PSH) is one of the major diseases in barley production regions worldwide. A total of 336 barley genotypes with diverse genetic backgrounds targeted for low‐input barley production were tested for seedling and adult‐plant stage resistance against six PSH races (0S0, 0S0‐1, 1S0, 4S0, 5S0 and 7S0) originated from India. The seedling resistance was evaluated by inoculating the barley genotypes with six races separately under controlled conditions in Shimla, India. The same barley genotypes were evaluated for adult‐plant stage resistance in the Agricultural Research Station (ARS) of Rajasthan Agriculture University, Durgapura, Rajasthan, India. Out of the 336 barley genotypes tested for seedling resistance, 119 (35.4%), 101 (30.1%), 87 (25.9%), 100 (29.8%), 91 (27.1%) and 70 (20.8%) genotypes were resistant to races 0S0, 0S0‐1, 1S0, 4S0, 5S0 and 7S0, respectively. In the field, 102 (30.3%) genotypes showed the resistance response of which 18 (5.3%) genotypes were highly resistant to PSH. Barley genotypes AM‐14, AM‐177, AM‐37, AM‐120, AM‐300, AM‐36, AM‐103, AM‐189, AM‐291, AM‐275 and AM‐274 showed resistance response to all six races at seedling and adult‐plant stages. Seedling resistance reported in the current study is effective against the newly emerged race 7S0 and previously reported five races in India. Therefore, resistant barley genotypes identified in the current study provided effective protection against all six races at seedling and adult‐plant stages. The stripe rust resistance identified in the current studies may be potential donors of stripe rust resistance to barley breeding programmes in India and elsewhere.
Predicting rheological behavior and baking quality of wheat flour using a GlutoPeak test
Authors: Rakita Slađana , Dokić Ljubica , Dapčević Hadnađev Tamara , Hadnađev Miroslav , Torbica Aleksandra 
Published: November 2017

AbstractThe purpose of this research was to gain an insight into the ability of the GlutoPeak instrument to predict flour functionality for bread making, as well as to determine which of the GlutoPeak parameters show the best potential in predicting dough rheological behavior and baking performance. Obtained results showed that GlutoPeak parameters correlated better with the indices of extensional rheological tests which consider constant dough hydration than with those which were performed at constant dough consistency. The GlutoPeak test showed that it is suitable for discriminating wheat varieties of good quality from those of poor quality, while the most discriminating index was maximum torque (MT). Moreover, MT value of 50 BU and aggregation energy value of 1,300 GPU were set as limits of wheat flour quality. The backward stepwise regression analysis revealed that a high‐level prediction of indices which are highly affected by protein content (gluten content, flour water absorption, and dough tenacity) was achieved by using the GlutoPeak indices. Concerning bread quality, a moderate prediction of specific loaf volume and an intense level prediction of breadcrumb textural properties were accomplished by using the GlutoPeak parameters. The presented results indicated that the application of this quick test in wheat transformation chain for the assessment of baking quality would be useful.Practical applicationsBaking test is considered as the most reliable method for assessing wheat‐baking quality. However, baking test requires trained stuff, time, and large sample amount. These disadvantages have led to a growing demand to develop new rapid tests which would enable prediction of baked product quality with a limited flour size. Therefore, we tested the possibility of using a GlutoPeak tester to predict loaf volume and breadcrumb textural properties. Discrimination of wheat varieties according to quality with a restricted flour amount was also examined. Furthermore, we proposed the limit values of GlutoPeak parameters which would be highly beneficial for millers and bakers when determine suitability of flour for end‐use.
Strategies to manage hepatitis C virus infection disease burden—Volume 4
Authors: Chen D. S. , Hamoudi W. , Mustapha B. , Layden J. , Nersesov A. , Reic T. , Garcia V. , Rios C. , Mateva L. , Njoya O. , Al‐Busafi S. A. , Abdelmageed M. K. , Abdulla M. , Adda D. , Akin O. , Al Baqali A. , Al Dweik N. , Al Ejji K. , Al ghazzawi I. , Al Kaabi S. , Al Naamani K. , Al Qamish J. , Al Sadadi M. , Al Salman J. , AlBadri M. , Al‐Romaihi H. E. , Ampofo W. , Antonov K. , Anyaike C. , Arome F. , Bane A. , Blach S. , Borodo M. M. , Brandon S. M. , Bright B. , Butt M. T. , Cardenas I. , Chan H. L. Y. , Chen C. J. , Chen P. J. , Chien R. N. , Chuang W. L. , Cuellar D. , Derbala M. , Elbardiny A. A. , Estes C. , Farag E. , Fung J. , Gamkrelidze I. , Genov J. , Ghandour Z. , Ghuloom M. , Gomez B. , Gunter J. , Habeeb J. , Hajelssedig O. , Himatt S. M. , Hrstic I. , Hu C. C. , Huang C. F. , Hui Y. T. , Jahis R. , Jelev D. , John A. K. , Kaliaskarova K. S. , Kamel Y. , Kao J. H. , Khamis J. , Khattabi H. , Khoudri I. , Konysbekova A. , Kotzev I. , Lai M. S. , Lao W. C. , Lee M. H. , Lesi O. , Li M. , Lo A. , Loo C. K. , Lukšić B. , Maaroufi A. , Malu A. O. , Mitova R. , Mohamed R. , Morović M. , Murphy K. , Nde H. , Ngige E. , Njouom R. , Nonković D. , Obekpa S. , Oguche S. , Okolo E. E. , Omede O. , Omuemu C. , Ondoa P. , Opare‐Sem O. , Owusu‐Ofori S. , Phillips R. O. , Prokopenko Y. N. , Razavi H. , Razavi‐Shearer D. , Razavi‐Shearer K. , Redae B. , Rinke de Wit T. , Robbins S. , Roberts L. R. , Sanad S. J. , Sharma M. , Simonova M. , Su T. H. , Sultan K. , Tan S. S. , Tchernev K. , Tsang O. T. Y. , Tsang S. , Tzeuton C. , Ugoeze S. , Uzochukwu B. , Vi R. , Vince A. , Wani H. U. , Wong V. W. S. , Workneh A. , Yacoub R. , Yesmembetov K. I. , Youbi M. , Yuen M. F. , Schmelzer J. D. 
Published: November 2017

SummaryThe hepatitis C virus (HCV) epidemic was forecasted through 2030 for 17 countries in Africa, Asia, Europe, Latin America and the Middle East, and interventions for achieving the Global Health Sector Strategy on viral hepatitis targets—“WHO Targets” (65% reduction in HCV‐related deaths, 90% reduction in new infections and 90% of infections diagnosed by 2030) were considered. Scaling up treatment and diagnosis rates over time would be required to achieve these targets in all but one country, even with the introduction of high SVR therapies. The scenarios developed to achieve the WHO Targets in all countries studied assumed the implementation of national policies to prevent new infections and to diagnose current infections through screening.
Estimating HCV disease burden—volume 4 (editorial)
Authors: Dore G.J. , Hatzakis A. , Negro F. , Waked I. 
Published: November 2017

SummaryHepatitis C virus (HCV) is a major global public health issue, with an estimated 71 million people living with HCV infection and a rising burden of cirrhosis, hepatocellular carcinoma (HCC) and liver‐related mortality. The advent of interferon‐free, direct acting antiviral‐based (DAA) therapies, with short duration (8‐12 weeks), high efficacy, excellent tolerability and ease of delivery (once daily oral dosing), is one of the major advances in clinical medicine in recent decades, and provides the opportunity to address this growing global HCV burden. In May 2014, January 2015 and December 2015, three supplements were published in the Journal of Viral Hepatitis presenting data from 47 countries on the historical epidemiology of HCV, the current HCV‐related morbidity and mortality and potential strategies to manage the HCV disease burden in the future. The countries included in those manuscripts were from multiple regions including North and South America, Europe, Asia, the Middle East, Africa and Oceania. In this supplement, data from an additional 17 countries are presented, following a similar pattern as in the previous manuscripts. These countries represent a mixture of high‐, middle‐ and low‐income countries that hail from five geographical regions: Africa, Asia, Europe, Middle East and South America. Expert advisory panels were convened in each country to identify the best data sources to use and to review the assumptions and outputs from the model. In the countries considered in the current analyses, there is a wide variance in the availability of robust data.