bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury
Authors: Yang Xiao-Sa , Yi Tai-Long , Zhang Sai , Xu Zhong-Wei , Yu Ze-Qi , Sun Hong-Tao , Yang Cheng , Tu Yue , Cheng Shi-Xiang 
Published: July 2017

AbstractNecroptosis, a novel type of programmed cell death, is involved in stroke-induced ischemic brain injury. Although studies have sought to explore the mechanisms of necroptosis, its signaling pathway has not yet to be completely elucidated. Thus, we used oxygen-glucose deprivation (OGD) and middle cerebral artery occlusion (MCAO) models mimicking ischemic stroke (IS) conditions to investigate mechanisms of necroptosis. We found that OGD and MCAO induced cell death, local brain ischemia and neurological deficit, while zVAD-fmk (zVAD, an apoptotic inhibitor), GSK’872 (a receptor interacting protein kinase-3 (RIP3) inhibitor), and combined treatment alleviated cell death and ischemic brain injury. Moreover, OGD and MCAO upregulated protein expression of the triggers of necroptosis: receptor interacting protein kinase-1 (RIP1), RIP3 and mixed lineage kinase domain-like protein (MLKL). The upregulation of these proteins was inhibited by GSK’872, combination treatments and RIP3 siRNA but not zVAD treatment. Intriguingly, hypoxia-inducible factor-1 alpha (HIF-1α), an important transcriptional factor under hypoxic conditions, was upregulated by OGD and MCAO. Similar to their inhibitory effects on aforementioned proteins upregulation, GSK’872, combination treatments and RIP3 siRNA decreased HIF-1α protein level. These findings indicate that necroptosis contributes to ischemic brain injury induced by OGD and MCAO and implicate HIF-1α, RIP1, RIP3, and MLKL in necroptosis.
N-terminal pro-brain natriuretic peptide and associated factors in the general working population: a baseline survey of the Uranosaki cohort study
Authors: Tanaka Atsushi , Yoshida Hisako , Kawaguchi Atsushi , Oyama Jun-ichi , Kotooka Norihiko , Toyoda Shigeru , Inoue Teruo , Natsuaki Masafumi , Node Koichi 
Published: July 2017

AbstractFew data on clinical characteristics associated with N-terminal pro-brain natriuretic peptide (NT-proBNP) or the clinical value of measuring NT-proBNP in the working population are available. The aim of the present study was to investigate the levels of NT-proBNP and their association with clinical variables in the Japanese general working population by using baseline data from the Uranosaki cohort study. In the study, the plasma concentration of NT-proBNP and some biomarkers were measured in addition to the standard health checkups at the workplace. Questionnaires regarding health-related quality of life (HR-QOL) were also completed. A total of 2140 participants were enrolled in the study. Plasma levels of NT-proBNP were positively associated with age, female sex, systolic blood pressure, pulse pressure, prevalent hypertension, smoking habit, high-density lipoprotein cholesterol (HDL-C), and prevalent proteinuria, and negatively associated with body mass index, lipid profiles except HDL-C, uric acid, renal function, and hemoglobin. Both the plasma concentration of high-molecular weight adiponectin and that of high-sensitivity troponin T were positively and independently associated with NT-proBNP. In addition, the HR-QOL score regarding sleep disorder was independently associated with NT-proBNP. Thus, we have obtained evidence that the plasma NT-proBNP is affected by several clinical variables in the general working population.
Flowering time in banana (Musa spp.), a day neutral plant, is controlled by at least three FLOWERING LOCUS T homologues
Authors: Chaurasia Akhilesh K. , Patil Hemant B. , Krishna Bal , Subramaniam V. R. , Sane Prafullachandra V. , Sane Aniruddha P. 
Published: July 2017

AbstractBanana is an important day neutral food crop with a long flowering/fruiting cycle that is affected by hot summers or cold winters in different places. Manipulating its life cycle requires an understanding of its flowering time machinery to bypass these stresses. Twelve FLOWERING LOCUS T (FT) and two TWIN SISTER OF FT (TSF) members were isolated from banana and their organization and expression pattern studied during development in two varieties that differ in flowering time namely Grand Nain (AAA genotype) and Hill banana (AAB genotype). The expression of at least 3 genes namely MaFT1, MaFT2 and MaFT5 (and to some extent MaFT7) increases just prior to initiation of flowering. These four genes and five others (MaFT3, MaFT4, MaFT8, MaFT12 and MaTSF1 could suppress the delayed flowering defect in the Arabidopsis ft-10 mutant and induce early flowering upon over-expression in the Col-0 ecotype. Most genes are diurnally regulated and differentially expressed during development and in various vegetative and reproductive tissues suggesting roles besides flowering. Subtle amino acid changes in these FT/TSF-like proteins provide interesting insights into the structure/function relationships of banana FTs vis-à-vis Arabidopsis. The studies provide a means for manipulation of flowering in banana for better management of resources and to reduce losses through abiotic stresses.
Assessing the shock state of the lunar highlands: Implications for the petrogenesis and chronology of crustal anorthosites
Authors: Pernet-Fisher J. F. , Joy K. H. , Martin D. J. P. , Donaldson Hanna K. L. 
Published: July 2017

AbstractOur understanding of the formation and evolution of the primary lunar crust is based on geochemical systematics from the lunar ferroan anorthosite (FAN) suite. Recently, much effort has been made to understand this suite’s petrologic history to constrain the timing of crystallisation and to interpret FAN chemical diversity. We investigate the shock histories of lunar anorthosites by combining Optical Microscope (OM) ‘cold’ cathodoluminescence (CL)-imaging and Fourier Transform Infrared (FTIR) spectroscopy analyses. In the first combined study of its kind, this study demonstrates that over ~4.5 Ga of impact processing, plagioclase is on average weakly shocked (<15 GPa) and examples of high shock states (>30 GPa; maskelynite) are uncommon. To investigate how plagioclase trace-element systematics are affected by moderate to weak shock (~5 to 30 GPa) we couple REE+Y abundances with FTIR analyses for FAN clasts from lunar meteorite Northwest Africa (NWA) 2995. We observe weak correlations between plagioclase shock state and some REE+Y systematics (e.g., La/Y and Sm/Nd ratios). This observation could prove significant to our understanding of how crystallisation ages are evaluated (e.g., plagioclase-whole rock Sm-Nd isochrons) and for what trace-elements can be used to differentiate between lunar lithologies and assess magma source compositional differences.
Ce3+-ion, Surface Oxygen Vacancy, and Visible Light-induced Photocatalytic Dye Degradation and Photocapacitive Performance of CeO2-Graphene Nanostructures
Authors: Khan Mohammad Ehtisham , Khan Mohammad Mansoob , Cho Moo Hwan 
Published: July 2017

AbstractCerium oxide nanoparticles (CeO2NPs) were fabricated and grown on graphene sheets using a facile, low cost hydrothermal approach and subsequently characterized using different standard characterization techniques. X-ray photoelectron spectroscopy and electron paramagnetic resonance revealed the changes in surface states, composition, changes in Ce4+to Ce3+ratio, and other defects. Transmission electron microscopy (TEM) and high resolution TEM revealed that the fabricated CeO2NPs to be spherical with particle size of ~10–12 nm. Combination of defects in CeO2NPs with optimal amount of two-dimensional graphene sheets had a significant effect on the properties of the resulting hybrid CeO2-Graphene nanostructures, such as improved optical, photocatalytic, and photocapacitive performance. The excellent photocatalytic degradation performances were examined by monitoring their ability to degrade Congo red ~94.5% and methylene blue dye ~98% under visible light irradiation. The photoelectrode performance had a maximum photocapacitance of 177.54 Fg−1and exhibited regular capacitive behavior. Therefore, the Ce3+-ion, surface-oxygen-vacancies, and defects-induced behavior can be attributed to the suppression of the recombination of photo-generated electron–hole pairs due to the rapid charge transfer between the CeO2NPs and graphene sheets. These findings will have a profound effect on the use of CeO2-Graphene nanostructures for future energy and environment-related applications.
Core shell lipid-polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment of metastatic prostate cancer
Authors: Wang Qi , Alshaker Heba , Böhler Torsten , Srivats Shyam , Chao Yimin , Cooper Colin , Pchejetski Dmitri 
Published: July 2017

AbstractMany prostate cancers relapse after initial chemotherapy treatment. Combining molecular and chemotherapy together with encapsulation of drugs in nanocarriers provides effective drug delivery and toxicity reduction. We developed core shell lipid-polymer hybrid nanoparticles (CSLPHNPs) with poly (lactic-co-glycolic acid) (PLGA) core and lipid layer containing docetaxel and clinically used inhibitor of sphingosine kinase 1 (SK1) FTY720 (fingolimod). We show for the first time that FTY720 (both free and in CSLPHNPs) re-sensitizes castrate resistant prostate cancer cells and tumors to docetaxel, allowing a four-fold reduction in effective dose. Our CSLPHNPs showed high serum stability and a long shelf life. CSLPHNPs demonstrated a steady uptake by tumor cells, sustained intracellular drug release and in vitro efficacy superior to free therapies. In a mouse model of human prostate cancer, CSLPHNPs showed excellent tumor targeting and significantly lower side effects compared to free drugs, importantly, reversing lymphopenia induced by FTY720. Overall, we demonstrate that nanoparticle encapsulation can improve targeting, provide low off-target toxicity and most importantly reduce FTY720-induced lymphopenia, suggesting its potential use in clinical cancer treatment.
Dispersive 2D Cherenkov radiation on a dielectric nano-film
Authors: Liu Weihao 
Published: July 2017

AbstractWe report a modified two-dimensional Cherenkov radiation, which occurs on a high-index dielectric nano-film driven by uniformly moving electron-beam. It is essentially different from the ordinary Cherenkov radiation in that, in the nondispersive medium, it shows unique dispersion characteristics—the waves with higher frequencies radiate at larger Cherenkov angles. Its radiation frequency and direction are essentially determined by structure parameters as well as the beam-velocity. By means of fully electromagnetic simulations and theoretical analyses, we explored the mechanism and requirements of this radiation. This new Cherenkov radiation may lead to promising applications in a broad range of fields.
Generally Applicable Transformation Protocols for Fluorescent Nanodiamond Internalization into Cells
Authors: Hemelaar Simon R. , van der Laan Kiran J. , Hinterding Sophie R. , Koot Manon V. , Ellermann Else , Perona-Martinez Felipe P. , Roig David , Hommelet Severin , Novarina Daniele , Takahashi Hiroki , Chang Michael , Schirhagl Romana 
Published: July 2017

AbstractFluorescent nanodiamonds (FNDs) are promising nanoprobes, owing to their stable and magnetosensitive fluorescence. Therefore they can probe properties as magnetic resonances, pressure, temperature or strain. The unprecedented sensitivity of diamond defects can detect the faint magnetic resonance of a single electron or even a few nuclear spins. However, these sensitivities are only achieved if the diamond probe is close to the molecules that need to be detected. In order to utilize its full potential for biological applications, the diamond particle has to enter the cell. Some model systems, like HeLa cells, readily ingest particles. However, most cells do not show this behavior. In this article we show for the first time generally applicable methods, which are able to transport fluorescent nanodiamonds into cells with a thick cell wall. Yeast cells, in particular Saccharomyces cerevisiae, are a favored model organism to study intracellular processes including aging on a cellular level. In order to introduce FNDs in these cells, we evaluated electrical transformation and conditions of chemical permeabilization for uptake efficiency and viability. 5% DMSO (dimethyl sulfoxide) in combination with optimized chemical transformation mix leads to high uptake efficiency in combination with low impact on cell biology. We have evaluated all steps in the procedure.
Cryptic speciation in pan-tropical sea urchins: a case study of an edge-of-range population of Tripneustes from the Kermadec Islands
Authors: Bronstein Omri , Kroh Andreas , Tautscher Barbara , Liggins Libby , Haring Elisabeth 
Published: July 2017

AbstractTripneustes is one of the most abundant and ecologically significant tropical echinoids. Highly valued for its gonads, wild populations of Tripneustes are commercially exploited and cultivated stocks are a prime target for the fisheries and aquaculture industry. Here we examine Tripneustes from the Kermadec Islands, a remote chain of volcanic islands in the southwest Pacific Ocean that mark the boundary of the genus’ range, by combining morphological and genetic analyses, using two mitochondrial (COI and the Control Region), and one nuclear (bindin) marker. We show that Kermadec Tripneustes is a new species of Tripneustes. We provide a full description of this species and present an updated phylogeny of the genus. This new species, Tripneustes kermadecensis n. sp., is characterized by having ambulacral primary tubercles occurring on every fourth plate ambitally, flattened test with large peristome, one to two occluded plates for every four ambulacral plates, and complete primary series of interambulacral tubercles from peristome to apex. It appears to have split early from the main Tripneustes stock, predating even the split of the Atlantic Tripneustes lineage. Its distinction from the common T. gratilla and potential vulnerability as an isolated endemic species calls for special attention in terms of conservation.
Pressure-induced anomalous valence crossover in cubic YbCu5-based compounds
Authors: Yamaoka Hitoshi , Tsujii Naohito , Suzuki Michi-To , Yamamoto Yoshiya , Jarrige Ignace , Sato Hitoshi , Lin Jung-Fu , Mito Takeshi , Mizuki Jun’ichiro , Sakurai Hiroya , Sakai Osamu , Hiraoka Nozomu , Ishii Hirofumi , Tsuei Ku-Ding , Giovannini Mauro , Bauer Ernst 
Published: July 2017

AbstractA pressure-induced anomalous valence crossover without structural phase transition is observed in archetypal cubic YbCu5 based heavy Fermion systems. The Yb valence is found to decrease with increasing pressure, indicating a pressure-induced crossover from a localized 4f13 state to the valence fluctuation regime, which is not expected for Yb systems with conventional c–f hybridization. This result further highlights the remarkable singularity of the valence behavior in compressed YbCu5-based compounds. The intermetallics Yb2Pd2Sn, which shows two quantum critical points (QCP) under pressure and has been proposed as a potential candidate for a reentrant Yb2+ state at high pressure, was also studied for comparison. In this compound, the Yb valence monotonically increases with pressure, disproving a scenario of a reentrant non-magnetic Yb2+ state at the second QCP.
Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats
Authors: Mulla Wesam , Etzion Sharon , Elyagon Sigal , Gillis Roni , Murninkas Michael , Konstantino Yuval , Mannhardt Ingra , Eschenhagen Thomas , Liel-Cohen Noah , Etzion Yoram 
Published: July 2017

AbstractBiventricular pacing is an important modality to improve left ventricular (LV) synchronization and long-term function. However, the biological effects of this treatment are far from being elucidated and existing animal models are limited and demanding. Recently, we introduced an implanted device for double-site epicardial pacing in rats and echocardiographically demonstrated favorable effects of LV and biventricular (LV-based) pacing modes typically observed in humans. Here, this new animal model was further characterized. Electrodes were implanted either on the right atria (RA) and right ventricle (RV) or on the RV and LV. Following recovery, rats were either used for invasive hemodynamic measurements (pressure-volume analysis) or exposed to sustained RV vs. biventricular tachypacing for 3 days. RV pacing compromised, while LV-based pacing modes markedly enhanced cardiac performance. Changes in LV performance were associated with prominent compensatory changes in arterial resistance. Sustained RV tachypacing increased the electrocardiogram QTc interval by 7.9 ± 3.1 ms (n = 6, p < 0.05), dispersed refractoriness between the right and left pacing sites and induced important molecular changes mainly in the early-activated septal tissue. These effects were not observed during biventricular tachypacing (n = 6). Our results demonstrate that the rat is an attractive new model to study the biological consequences of LV dyssynchrony and resynchronization.
Su-Schrieffer-Heeger chain with one pair of $$\mathcal{P}\mathcal{T}$$-symmetric defects
Authors: Jin L. , Wang P. , Song Z. 
Published: July 2017

AbstractThe topologically nontrivial edge states induce $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

transition in Su-Schrieffer-Heeger (SSH) chain with one pair of gain and loss at boundaries. In this study, we investigated a pair of $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

-symmetric defects located inside the SSH chain, in particular, the defects locations are at the chain centre. The $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

symmetry breaking of the bound states leads to the $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

transition, the $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

-symmetric phases and the localized states were studied. In the broken $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

-symmetric phase, all energy levels break simultaneously in topologically trivial phase; however, two edge states in topologically nontrivial phase are free from the influence of the $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

-symmetric defects. We discovered $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

-symmetric bound states induced by the $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

-symmetric local defects at the SSH chain centre. The $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

-symmetric bound states significantly increase the $$\mathcal{P}\mathcal{T}$$

𝒫

𝒯

transition threshold and coalesce to the topologically protected zero mode with vanishing probabilities on every other site of the left-half chain and the right-half chain, respectively.
Enhanced Learning through Multimodal Training: Evidence from a Comprehensive Cognitive, Physical Fitness, and Neuroscience Intervention
Authors: Ward N. , Paul E. , Watson P. , Cooke G. E. , Hillman C. H. , Cohen N. J. , Kramer A. F. , Barbey A. K. 
Published: July 2017

AbstractThe potential impact of brain training methods for enhancing human cognition in healthy and clinical populations has motivated increasing public interest and scientific scrutiny. At issue is the merits of intervention modalities, such as computer-based cognitive training, physical exercise training, and non-invasive brain stimulation, and whether such interventions synergistically enhance cognition. To investigate this issue, we conducted a comprehensive 4-month randomized controlled trial in which 318 healthy, young adults were enrolled in one of five interventions: (1) Computer-based cognitive training on six adaptive tests of executive function; (2) Cognitive and physical exercise training; (3) Cognitive training combined with non-invasive brain stimulation and physical exercise training; (4) Active control training in adaptive visual search and change detection tasks; and (5) Passive control. Our findings demonstrate that multimodal training significantly enhanced learning (relative to computer-based cognitive training alone) and provided an effective method to promote skill learning across multiple cognitive domains, spanning executive functions, working memory, and planning and problem solving. These results help to establish the beneficial effects of multimodal intervention and identify key areas for future research in the continued effort to improve human cognition.
Genomic epidemiology of global Klebsiella pneumoniae carbapenemase (KPC)-producing Escherichia coli
Authors: Stoesser N. , Sheppard A. E. , Peirano G. , Anson L. W. , Pankhurst L. , Sebra R. , Phan H. T. T. , Kasarskis A. , Mathers A. J. , Peto T. E. A. , Bradford P. , Motyl M. R. , Walker A. S. , Crook D. W. , Pitout J. D. 
Published: July 2017

AbstractThe dissemination of carbapenem resistance in Escherichia coli has major implications for the management of common infections. blaKPC, encoding a transmissible carbapenemase (KPC), has historically largely been associated with Klebsiella pneumoniae, a predominant plasmid (pKpQIL), and a specific transposable element (Tn4401, ~10 kb). Here we characterize the genetic features of blaKPC emergence in global E. coli, 2008–2013, using both long- and short-read whole-genome sequencing. Amongst 43/45 successfully sequenced blaKPC-E. coli strains, we identified substantial strain diversity (n = 21 sequence types, 18% of annotated genes in the core genome); substantial plasmid diversity (≥9 replicon types); and substantial blaKPC-associated, mobile genetic element (MGE) diversity (50% not within complete Tn4401 elements). We also found evidence of inter-species, regional and international plasmid spread. In several cases blaKPC was found on high copy number, small Col-like plasmids, previously associated with horizontal transmission of resistance genes in the absence of antimicrobial selection pressures. E. coli is a common human pathogen, but also a commensal in multiple environmental and animal reservoirs, and easily transmissible. The association of blaKPC with a range of MGEs previously linked to the successful spread of widely endemic resistance mechanisms (e.g. blaTEM, blaCTX-M) suggests that it may become similarly prevalent.
Strong Coherent Light Amplification with Double Electromagnetically Induced Transparency Coherences
Authors: Wang Dan , Liu Chao , Xiao Changshun , Zhang Junxiang , Alotaibi Hessa M. M. , Sanders Barry C. , Wang Li-Gang , Zhu Shiyao 
Published: July 2017

AbstractWe experimentally demonstrate coherent amplification of probe field in a tripod-type atoms driven by strong coupling, signal and weak probe fields. We suppress linear and nonlinear atomic absorptions for resonant and near resonant probe via double electromagnetically induced transparency (DEIT). Combining these advantages of suppressed absorption along with temperature- or atomic-density-controlled transfer of population(ToP) between hyperfine ground states, we can induce near-resonant amplification of probe through stimulated Raman scattering(SRS) pumped by low-intensity signal field. The increased population difference of initial and final states of SRS due to increased ToP rate, together with reduced absorption at the second EIT window in an optically thick Cesium vapor, gives rise to highly effective coherent amplification.