bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drilling into an active mofette: pilot-hole study of the impact of CO&lt;sub&gt;2&lt;/sub&gt;-rich mantle-derived fluids on the geo–bio interaction in the western Eger Rift (Czech Republic)
Authors: Bussert Robert , Kämpf Horst , Flechsig Christina , Hesse Katja , Nickschick Tobias , Liu Qi , Umlauft Josefine , Vylita Tomáš , Wagner Dirk , Wonik Thomas , Flores Hortencia Estrella , Alawi Mashal 
Published: November 2017

Abstract. Microbial life in the continental deep biosphere is closely linked to geodynamic processes, yet this interaction is poorly studied. The Cheb Basin in the western Eger Rift (Czech Republic) is an ideal place for such a study because it displays almost permanent seismic activity along active faults with earthquake swarms up to ML 4.5 and intense degassing of mantle-derived CO2 in conduits that show up at the surface in form of mofettes. We hypothesize that microbial life is significantly accelerated in active fault zones and in CO2 conduits, due to increased fluid and substrate flow. To test this hypothesis, pilot hole HJB-1 was drilled in spring 2016 at the major mofette of the Hartoušov mofette field, after extensive pre-drill surveys to optimize the well location. After drilling through a thin caprock-like structure at 78.5 m, a CO2 blowout occurred indicating a CO2 reservoir in the underlying sandy clay. A pumping test revealed the presence of mineral water dominated by Na+, Ca2+, HCO3−, SO42− (Na-Ca-HCO3-SO4 type) having a temperature of 18.6 °C and a conductivity of 6760 µS cm−1. The high content of sulfate (1470 mg L−1) is typical of Carlsbad Spa mineral waters. The hole penetrated about 90 m of Cenozoic sediments and reached a final depth of 108.50 m in Palaeozoic schists. Core recovery was about 85 %. The cored sediments are mudstones with minor carbonates, sandstones and lignite coals that were deposited in a lacustrine environment. Deformation structures and alteration features are abundant in the core. Ongoing studies will show if they result from the flow of CO2-rich fluids or not.
Zhang Peili: Record. Repeat.
Authors: Larson Ellen 
Published: November 2017

Review ofExhibition catalog: Orianna Cacchione, Zhang Peili: Record. Repeat. Exh. Cat. Chicago: Art Institute of Chicago, 2017. 96 pp.; 50 color ills. Hardback $25.00 (9780300226225) Exhibition schedule: Art Institute of Chicago, March 31–July 9, 2017
Descrição de contingências durante a leitura de histórias e o comportamento de crianças: um estudo exploratório
Authors: Gonçalves Meira de Almeida Christiana , Almeida-Verdu Ana Claudia Moreira , Cavalcante Maria Regina 
Published: November 2017

<p>O estudo investigou os efeitos da descrição de contingências durante a leitura de histórias sobre o comportamento de crianças entre 8 e 10 anos. No grupo 1, duas crianças foram expostas à uma história com desfecho positivo para o comportamento-alvo de pegar doces antes da festa (A) e, em seguida, outra história com desfecho aversivo (B). No grupo 2, outras duas crianças foram expostas às mesmas histórias na ordem inversa. No grupo 3, três crianças ouviram duas histórias (C e D) sobre festa de aniversário, mas sem menção do comportamento-alvo. Após cada leitura, as crianças eram deixadas em situação similar à descrita nas histórias. A frequência de comportamentos direcionados aos doces foi registrada, sendo maior após a leitura da história A do que após a leitura da história B. Sugere-se que a descrição das contingências durante a narração das histórias controlou o desempenho subsequente dos participantes. </p>
Comprometimento organizacional: questões que cercam sua natureza e os seus limites conceituais
Authors: Menezes Igor Gomes , Aguiar Carolina Villa Nova , Bastos Antonio Virgilio Bittencourt 
Published: November 2017

<p>O comprometimento organizacional, um dos fenômenos mais investigados no campo do comportamento organizacional, pode ser considerado um construto polissêmico e multifacetado. Este trabalho buscou discutir a complexidade e dispersão que cerca o conceito de comprometimento organizacional, envolvendo três problemas centrais: 1º) a quantidade de interfaces teóricas entre comprometimento organizacional e outros construtos da área organizacional; 2º) o grande desequilíbrio entre estudos que tomam o construto como uma atitude em detrimento de definições que enfatizem indicadores comportamentais; e 3º) a dimensionalidade do construto e a falta de consenso a respeito de quantas e quais são as bases constitutivas do comprometimento organizacional. Além de sistematizar os principais problemas sobre o construto, este estudo sugere alguns caminhos de investigação teórica e empírica que poderiam minimizar os problemas que cercam esta vertente de pesquisa, em razão das questões conceituais que caracterizam o seu construto central. </p>
Lack of additional effects of long‐term, low‐dose clarithromycin combined treatment compared with topical steroids alone for chronic rhinosinusitis in China: a randomized, controlled trial
Authors: Deng Jie , Chen Fenghong , Lai YinYan , Luo Qing , Xu Rui , Ou Chunquan , Fu Qingling , Shi Jianbo 
Published: November 2017

BackgroundIn China, clarithromycin is considered an effective treatment option for chronic rhinosinusitis (CRS) due to its unique immunopathologic characteristics. Our study's aim was to determine whether a topical steroid and clarithromycin combination is better than a single topical steroid for Chinese patients with CRS.MethodsPatients with CRS with/without nasal polyps were included in this study and randomly assigned to a clarithromycin plus budesonide aqua nasal spray group (CLM + BUD, clarithromycin 0.25 g/d and budesonide 256 μg/d) or a budesonide‐alone group (BUD, budesonide 256 μg/d). The treatment period was 3 months. The primary outcome was visual analog scale (VAS) score for 5 major symptoms and a general nasal symptom. Other assessments included the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), computed tomography scan (Lund‐Mackay score), and rigid nasal endoscopy (Lund‐Kennedy score). Nasal secretion evaluation was the secondary outcome.ResultsSeventy‐four patients were included and randomly assigned to the CLM + BUD group (n = 38) or the BUD group (n = 36). VAS scores for nasal obstruction, rhinorrhea, smell reduction, headache, nasal pain, and general nasal symptom were markedly improved in both treatment arms, but the differences between groups were not significant. Furthermore, SNOT‐22, Lund‐Mackay, and Lund‐Kennedy scores improved significantly after treatment in both groups, and were slightly better in the CLM + BUD group. For the responders in the CLM + BUD group, interleukin (IL)‐6 and IL‐8 were markedly reduced.ConclusionThe combination of CLM + BUD for the treatment of first‐time‐diagnosed CRS in this Chinese population cohort did not show a better effect compared with a single BUD regimen, but it may have a better effect in some patients with increased IL‐6 or IL‐8.
Post-cataract eye drops can be avoided by depot steroid injections
Authors: Buchan John C , Cleveland Victoria , Sutton Heather , Cassels-Brown Andy 
Published: November 2017

There are over 400 000 cataract operations now being performed annually in the UK. With the majority of those patients being older people, comorbidities such as dementia or arthritis can prevent patients putting in their own post-operative eye drops. Where there is a lack of family or other support, district nursing services are often called upon to administer these eye drops, which are typically prescribed four times a day for 4 weeks, thus potentially totalling 112 visits for drop instillation per patient. To reduce the burden of these post-operative eye drops on district nursing services, administration of an intra-operative sub-Tenon's depot steroid injection is possible for cataract patients who then do not require any post-operative drop instillation. As a trial of this practice, 16 such patients were injected in one year, thus providing a reduction of 1792 in the number of visits requested. Taking an estimated cost of each district nurse visit of £38, this shift in practice potentially saved more than £68 000; the additional cost of the injection over the cost of eye drops was just £8.80 for the year. This practice presents an opportunity to protect valuable community nursing resources, but advocacy for change in practice would be needed with secondary care, or via commissioners.
WTP for baby milk formula in China: Using attribute nonattendance as a priori information to select attributes in choice experiment
Authors: Quan Shiwen , Zeng Yinchu , Yu Xiaohua , Bao Te 
Published: November 2017

AbstractIt is well‐known that these nonattended attributes in choice experiments (CE) could cause some bias. A combination of two successive CEs are designed with focus on consumers’ demand for the attributes of baby milk formula in China, where the first CE includes the full set of attributes and the second excludes consumers’ self‐reported nonattended attributes in the first CE. Significant discrepancies are detected for both WTPs for an individual attribute and the total WTPs (the sum of all WTPs for individual attributes in each CE), and in most cases WTPs decrease as a result of excluding the ignored attributes. Changes in WTP are mainly driven by the variation of choice task complexity. However, there is no significant difference in the influence of excluding nonattended attributes on the WTPs for the same attended attribute in different subsamples. In addition, we also find that consumers in China have significantly higher but dispersed WTP values for imported (11.6–47.0%), organic (6.9–52.5%), and probiotics (7.3–35.5%) and sugar‐free (5.9–26.0%) attributes for baby milk formula. [EconLit citations: C90, D12, Q13, Q18].
Kreisförmiger lichtinduzierter Elektronentransfer in einer Donor‐ Akzeptor‐Akzeptor‐Triade
Authors: Larsen Christopher B. , Wenger Oliver S. 
Published: November 2017

AbstractEine Elektronen‐Donor‐Akzeptor‐Akzeptor(D‐A1‐A2)‐Triade liefert die erste direkte Evidenz für die Realisierung des Konzepts eines lichtinduzierten molekularen Stromkreises. Nach Lichtanregung in einen optischen Ladungstransferübergang zwischen D und A1 sowie anschließendem thermischem Elektronentransfer von A1.− auf A2 folgt eine geometrische Reorganisation im ladungsgetrennten D.+‐A1‐A2.−‐Zustand mit Bildung eines Ionenpaarkontakts. Dies ermöglicht eine “Vorwärts”‐Ladungsrekombination zwischen A2.− und D.+, die den molekularen Stromkreis mit einer geschätzten Quanteneffizienz von 4 % in Toluol bei 298 K schließt.
Circular Photoinduced Electron Transfer in a Donor‐Acceptor‐Acceptor Triad
Authors: Larsen Christopher B. , Wenger Oliver S. 
Published: November 2017

AbstractAn electron‐donor‐acceptor‐acceptor (D‐A1‐A2) triad has been developed that provides the first proof‐of‐concept for a photoinitiated molecular circuit. After photoexcitation into an optical charge‐transfer transition between D and A1, subsequent thermal electron‐transfer from A1.− to A2 is followed by geometric rearrangement in the D.+‐A1‐A2.− charge‐separated state to form an ion‐pair contact. This facilitates “forward” charge recombination between A2.− and D.+ to complete the molecular circuit with an estimated quantum efficiency of 4 % in toluene at 298 K.
A low‐cost clay‐based heterogeneous Fenton‐like catalyst: Activation, efficiency enhancement, and mechanism study
Authors: Liu Zhengjiang , Ma Huiyan , Liu Juming , Xing Lei , Cheng Lin , Yang Jucai , Mao Baodong , Zhang Qiancheng 
Published: November 2017

AbstractIn this work, Hangjin2# clay (HC), a natural iron‐contained clay mineral first discovered in Inner Mongolia of China, is found to be able to catalyze the heterogeneous Fenton reaction efficiently upon rational modification. After activation using dilute sulfuric acid, the HC prohibited a significantly enhanced activity for heterogeneous Fenton reaction. Via acid activation process, Fe2+/Fe3+ redox can be introduced on the surface of sulfuric acid‐activated Hangjin2# clay (SHC), and Brønsted acid sites can be also created on the surface of SHC. Furthermore, Brønsted acid sites could effectively promote the generation of •OH for methyl orange (MO) oxidation and facilitate the Fe3+/Fe2+ redox process. Fenton degradation of MO was used to evaluate the effect of acid activation on the catalytic activities of SHC. Experimental results revealed that the high activity of SHC was mainly attributed to the synergetic effect of the abundant acid sites on catalyst surface and the Fe3+/Fe2+ redox process. In addition, quenching studies confirmed that •OH radicals were principally responsible for the degradation of MO. More importantly, MO degradation for 3 consecutive cycles demonstrated SHC exhibited reusable and stable activity.
RNA interference‐mediated knockdown and virus‐induced suppression of Troponin C gene adversely affect the behavior or fitness of the green rice leafhopper, Nephotettix cincticeps
Authors: Lan Hanhong , Hong Xiaojing , Huang Ranran , Lin Xin , Li Qinghuang , Li Kaihui , Zhou Tao 
Published: November 2017

AbstractThe green rice leafhopper, Nephotettix cincticeps, is a major rice pest in Southeast Asia and Southern China. Novel control strategies must be explored to control the rice pest. Behavior or fitness regulation of insect by modulating the Troponin C (TnC) may be a novel strategy in the comprehensive management of the insect pest. However, characterizations and functions of TnC, especially regarding effect of its RNA interference‐mediated gene knockdown on the behavior or fitness of N. cincticeps remain unknown. Here, we successfully cloned and characterized TnC gene from N. cincticeps (Nc‐TnC). We demonstrated that Nc‐TnC ubiquitously transcribed at all development stages and special tissues in adult insects, with relative higher levels at the adult stage and in the intestinal canal. Microinjection‐ or oral membrane feeding‐based transient knockdown of Nc‐TnC adversely affected the performance or fitness, such as the decreased survival, feeding capacity, weight, and fecundity of N. cincticeps. Furthermore, we revealed that the expression of Nc‐TnC was suppressed by its interaction with rice dwarf virus‐encoded nonstructural protein 10, which ultimately affected detrimentally the corresponding parameters of the performance or fitness of N. cincticeps. In conclusion, our data deepen understanding of Nc‐TnC functions during the development of and viral infection in N. cincticeps. It imply Nc‐TnC may serve as a potential target for N. cincticeps control in future.
Unravelling the Carbohydrate‐Binding Preferences of the Carbohydrate‐Binding Modules of AMP‐Activated Protein Kinase
Authors: Mobbs Jesse I. , Di Paolo Alex , Metcalfe Riley D. , Selig Emily , Stapleton David I. , Griffin Michael D. W. , Gooley Paul R. 
Published: November 2017

AbstractThe β subunit of adenosine monophosphate (AMP)‐activated protein kinase (AMPK), which exists as two isoforms (β1 and β2) in humans, has a carbohydrate‐binding module (CBM) that interacts with glycogen. Although the β1‐ and β2‐CBMs are structurally similar, with strictly conserved ligand‐contact residues, they show different carbohydrate affinities. β2‐CBM shows the strongest affinity for both branched and unbranched oligosaccharides and it has recently been shown that a Thr insertion into β2‐CBM (Thr101) forms a pocket to accommodate branches. This insertion does not explain why β2‐CBM binds all carbohydrates with stronger affinity. Herein, it is shown that residue 134 (Val for β2 and Thr for β1), which does not come into contact with a carbohydrate, appears to account for the affinity difference. Characterisation by NMR spectroscopy, however, suggests that mutant β2‐Thr101Δ/Val134Thr differs from that of β1‐CBM, and mutant β1‐Thr101ins/Thr134Val differs from that of β2‐CBM. Furthermore, these mutants are less stable to chemical denaturation, relative to that of wild‐type β‐CBMs, which confounds the affinity analyses. To support the importance of Thr101 and Val134, the ancestral CBM has been constructed. This CBM retains Thr101 and Val134, which suggests that the extant β1‐CBM has a modest loss of function in carbohydrate binding. Because the ancestor bound carbohydrate with equal affinity to that of β2‐CBM, it is concluded that residue 134 plays an indirect role in carbohydrate binding.
[Ni3(HCOO)6]/Poly(styrene‐b‐butadiene‐b‐styrene) Mixed‐Matrix Membranes for CH4/N2 Gas Separation
Authors: Wang Shumin , Guo Qingping , Liang Shujun , Li Peng , Li Xin , Luo Jujie 
Published: November 2017

AbstractFor the evaluation of CH4/N2 separation, mixed‐matrix membranes (MMMs) were fabricated by adding [Ni3(HCOO)6] as a filler into the poly(styrene‐b‐butadiene‐b‐styrene) (SBS) polymer. The structures and morphologies of [Ni3(HCOO)6] and [Ni3(HCOO)6]/SBS MMMs were characterized by different techniques, proving the crystalline structure of [Ni3(HCOO)6] in SBS polymer matrices. The structural integrity of the MMMs and good compatibility between [Ni3(HCOO)6] and SBS polymer were examined by scanning electron microscopy. Gas permeation measurements revealed that membranes containing various [Ni3(HCOO)6] loadings exhibited different separation performances. The operational temperature exerted a significantly positive effect on the separation of CH4 and N2.
Organic‐Inorganic Hybrid Materials: Multi‐Functional Solids for Multi‐Step Reaction Processes
Authors: Díaz Urbano , Corma Avelino 
Published: November 2017

AbstractThe design of new hybrid materials with tailored properties at the nano‐, meso‐, and macro‐scale, with the use of structural functional nanobuilding units, is carried out to obtain specific multi‐functional materials. Organization into controlled 1D, 2D, and 3D architectures with selected functionalities is key for developing advanced catalysts, but this is hardly accomplished using conventional synthesis procedures. The use of pre‐formed nanostructures, derived either from known materials or made with specific innovative synthetic methodologies, has enormous potential in the generation of multi‐site catalytic materials for one‐pot processes. The present concept article introduces a new archetype wherein self‐assembled nanostructured builder units are the base for the design of multifunctional catalysts, which combine catalytic efficiency with fast reactant and product diffusion. The article addresses a new generation of versatile hybrid organic‐inorganic multi‐site catalytic materials for their use in the production of (chiral) high‐added‐value products within the scope of chemicals and fine chemicals production. The use of those multi‐reactive solids for more nanotechnological applications, such as sensors, due to the inclusion of electron donor‐acceptor structural arrays is also considered, together with the adsorption‐desorption capacities due to the combination of hydrophobic and hydrophilic sub‐domains. The innovative structured hybrid materials for multipurpose processes here considered, can allow the development of multi‐stage one‐pot reactions with industrial applications, using the materials as one nanoreactor systems, favoring more sustainable production pathways with economic, environmental and energetic advantages.
Evidence for Iron‐Catalyzed α‐Phosphinidene Elimination with Phenylphosphine
Authors: Pagano Justin K. , Ackley Brandon J. , Waterman Rory 
Published: November 2017

AbstractThe ubiquitous half‐sandwich iron complex [CpFe(CO)2Me] (Cp=η5‐C5H5) appears to be a catalyst for α‐phosphinidene elimination from primary phosphines. Dehydrocoupling reactions provided initial insight into this unusual reaction mechanism, and trapping reactions with organic substrates gave products consistent with an α elimination mechanism, including a rare example of a three‐component reaction. The substrate scope of this reaction is consistent with generation of a triplet phosphinidene. In all, this study presents catalytic phosphinidene transfer to unsaturated organic substrates.
Discovery of Potent EGFR Inhibitors through the Incorporation of a 3D‐Aromatic‐Boron‐Rich‐Cluster into the 4‐Anilinoquinazoline Scaffold: Potential Drugs for Glioma Treatment
Authors: Couto Marcos , García María Fernanda , Alamón Catalina , Cabrera Mauricio , Cabral Pablo , Merlino Alicia , Teixidor Francesc , Cerecetto Hugo , Viñas Clara 
Published: November 2017

AbstractNew 1,7‐closo‐carboranylanilinoquinazoline hybrids have been identified as EGFR inhibitors, one of them with higher affinity than the parent compound erlotinib. The comparative docking analysis with compounds bearing bioisoster‐substructures, demonstrated the relevance of the 3D aromatic‐boron‐rich moiety for interacting into the EGFR ATP binding region. The capability to accumulate in glioma cells, the ability to cross the blood–brain barrier and the stability on simulated biological conditions, render these molecules as lead compounds for further structural modifications to obtain dual action drugs to treat glioblastoma.
Isomerization of Allylic Alcohols to Ketones Catalyzed by Well‐Defined Iron PNP Pincer Catalysts
Authors: Xia Tian , Wei Zhihong , Spiegelberg Brian , Jiao Haijun , Hinze Sandra , de Vries Johannes G. 
Published: November 2017

Abstract[Fe(PNP)(CO)HCl] (PNP=di‐(2‐diisopropylphosphanyl‐ethyl)amine), activated in situ with KOtBu, is a highly active catalyst for the isomerization of allylic alcohols to ketones without an external hydrogen supply. High reaction rates were obtained at 80 °C, but the catalyst is also sufficiently active at room temperature with most substrates. The reaction follows a self‐hydrogen‐borrowing mechanism, as verified by DFT calculations. An alternative isomerization through alkene insertion and β‐hydride elimination could be excluded on the basis of a much higher barrier. In alcoholic solvents, the ketone product is further reduced to the saturated alcohol.
Highly Selective Ruthenium‐Catalyzed Direct Oxygenation of Amines to Amides
Authors: Ray Ritwika , Hazari Arijit Singha , Chandra Shubhadeep , Maiti Debabrata , Lahiri Goutam Kumar 
Published: November 2017

AbstractReports on aerobic oxidation of amines to amides are rare, and those reported suffer from several limitations like poor yield or selectivity and make use of pure oxygen under elevated pressure. Herein, we report a practical and an efficient ruthenium‐catalyzed synthetic protocol that enables selective oxidation of a broad range of primary aliphatic, heterocyclic and benzylic amines to their corresponding amides, using readily available reagents and ambient air as the sole oxidant. Secondary amines instead, yield benzamides selectively as the sole product. Mechanistic investigations reveal intermediacy of nitriles, which undergo hydration to afford amide as the final product.
De Novo Synthesis of Benzannelated Heterocycles
Authors: Feierfeil Johannes , Magauer Thomas 
Published: November 2017

AbstractBenzannelated heterocycles such as indoles and indazoles are prominent structural motifs found in natural products, pharmaceuticals and agrochemicals. For their synthesis, chemists traditionally either functionalize commercially available heterocycles or resort to transformations that make use of benzene‐derived building blocks. Here, we report a powerful cascade reaction that enables the de novo construction of variously substituted indoles, indazoles, benzofurans and benzothiophenes from readily available bicyclo[3.1.0]hexan‐2‐ones. The transformation can be conducted under mild, non‐anhydrous conditions. For the synthesis of indoles, mechanistic studies revealed that the electrocyclic ring‐opening of the bicyclic ring‐system and aromatization precedes the 3,3‐sigmatropic rearrangement.