bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Multifunctional Nanoplatform against Multidrug Resistant Cancer: Merging the Best of Targeted Chemo/Gene/Photothermal Therapy
Authors: Cheng Wei , Nie Junpeng , Gao Nansha , Liu Gan , Tao Wei , Xiao Xiaojun , Jiang Lijuan , Liu Zhigang , Zeng Xiaowei , Mei Lin 
Published: October 2017

AbstractSynergistic therapy that combines chemo‐, gene‐, or photothermal means shows great potential for enhancing the therapeutic effects on cancers. Tumor‐targeted nanoparticles based on a doxorubicin (DOX)‐gated mesoporous silica nanocore (MSN) encapsulated with permeability glycoprotein (P‐gp) small interfering RNA (siRNA) and a polydopamine (PDA) outer layer for DOX loading and folic acid decoration are designed. The multifunctional nanoplatform tactfully integrates chemo‐ (DOX), gene‐ (P‐gp siRNA), and photothermal (PDA layer) substances in one system. In vitro results reveal that DOX release behaviors are both pH‐ and thermal‐responsive and the release of co‐delivered P‐gp siRNA is also pH‐dependent due to the pH‐cleavable DOX gatekeeper on MSN. In addition, due to the near‐infrared light‐responsive PDA outer layer and folic acid conjugation, the nanoparticles exhibit outstanding photothermal activity and selective cell targeting ability. Subsequently, in vitro and in vivo antitumor experiments both demonstrate the enhanced antitumor efficacy of the multifunctional nanoparticles, indicating the significance of synergistic therapy combining chemo‐, gene‐, and photothermal treatments in one system.
Suppressing Lithium Dendrite Growth by Metallic Coating on a Separator
Authors: Lee Hongkyung , Ren Xiaodi , Niu Chaojiang , Yu Lu , Engelhard Mark H. , Cho Inseong , Ryou Myung‐Hyun , Jin Hyun Soo , Kim Hee‐Tak , Liu Jun , Xu Wu , Zhang Ji‐Guang 
Published: October 2017

AbstractLithium (Li) metal is one of the most promising candidates for the anode in high‐energy‐density batteries. However, Li dendrite growth induces a significant safety concerns in these batteries. Here, a multifunctional separator through coating a thin electronic conductive film on one side of the conventional polymer separator facing the Li anode is proposed for the purpose of Li dendrite suppression and cycling stability improvement. The ultrathin Cu film on one side of the polyethylene support serves as an additional conducting agent to facilitate electrochemical stripping/deposition of Li metal with less accumulation of electrically isolated or “dead” Li. Furthermore, its electrically conductive nature guides the backside plating of Li metal and modulates the Li deposition morphology via dendrite merging. In addition, metallic Cu film coating can also improve thermal stability of the separator and enhance the safety of the batteries. Due to its unique beneficial features, this separator enables stable cycling of Li metal anode with enhanced Coulombic efficiency during extended cycles in Li metal batteries and increases the lifetime of Li metal anode by preventing short‐circuit failures even under extensive Li metal deposition.
Slow‐Photon‐Effect‐Induced Photoelectrical‐Conversion Efficiency Enhancement for Carbon‐Quantum‐Dot‐Sensitized Inorganic CsPbBr3 Inverse Opal Perovskite Solar Cells
Authors: Zhou Shujie , Tang Rui , Yin Longwei 
Published: October 2017

AbstractAll‐inorganic cesium lead halide perovskite is suggested as a promising candidate for perovskite solar cells due to its prominent thermal stability and comparable light absorption ability. Designing textured perovskite films rather than using planar‐architectural perovskites can indeed optimize the optical and photoelectrical conversion performance of perovskite photovoltaics. Herein, for the first time, this study demonstrates a rational strategy for fabricating carbon quantum dot (CQD‐) sensitized all‐inorganic CsPbBr3 perovskite inverse opal (IO) films via a template‐assisted, spin‐coating method. CsPbBr3 IO introduces slow‐photon effect from tunable photonic band gaps, displaying novel optical response property visible to naked eyes, while CQD inlaid among the IO frameworks not only broadens the light absorption range but also improves the charge transfer process. Applied in the perovskite solar cells, compared with planar CsPbBr3, slow‐photon effect of CsPbBr3 IO greatly enhances the light utilization, while CQD effectively facilitates the electron–hole extraction and injection process, prolongs the carrier lifetime, jointly contributing to a double‐boosted power conversion efficiency (PCE) of 8.29% and an increased incident photon‐to‐electron conversion efficiency of up to 76.9%. The present strategy on CsPbBr3 IO to enhance perovskite PCE can be extended to rationally design other novel optoelectronic devices.
Improving Efficiency and Stability of Perovskite Solar Cells by Modifying Mesoporous TiO2–Perovskite Interfaces with Both Aminocaproic and Caproic acids
Authors: Chen Ruihao , Cao Jing , Wu Youyunqi , Jing Xiaojing , Wu Binghui , Zheng Nanfeng 
Published: October 2017

AbstractIn the field of photovoltaic industry, organolead halide perovskite solar cells (PSCs) as cleaner and cheaper photo‐voltaic devices have shown a bright prospect with power conversion efficiency (PCE) rapidly climbing from 3.8% to certified 22.1% in a few years. Interface engineering has been proven to be highly effective to solve the instability‐to‐moisture issue and enhance the performance of PSCs. Here, this work develops a simple and easy‐proceeding strategy that depositing both aminocaproic acid [H2NCH2(CH2)4COOH, abbreviated as AmCA] and caproic acid [CH3(CH2)4COOH, CA] at the mesoporous TiO2/perovskite interface leads to significant enhancement in both the efficiency and stability of PSCs. These two organic modifiers work synergistically to enhance the overall performance of PSCs by promoting electron transfer through the interaction between amino groups on AmCA and perovskite layer, and resisting moisture with alkyl chains from CA. The champion efficiency of modified cells reaches 18.2%, with an average PCE of 17.5% in reliable reproducibility, with significant improvement in stability under 50 ± 5% relative humidity in air. The developed simple interfacial modification approach should be effective to enhance both efficiency and stability of PSCs with other architectures as well. More importantly, this scenario may provide insight into the commercialization of perovskite solar cells in the not‐too‐distant future.
Self‐Powered UV Photodetector Array Based on P3HT/ZnO Nanowire Array Heterojunction
Authors: Ouyang Bangsen , Zhang Kewei , Yang Ya 
Published: October 2017

AbstractSelf‐powered photodetector array based on organic–inorganic heterojunction is extremely suitable for light imaging applications, owing to their unique flexibility and stability. Here, a self‐powered ultraviolet (UV) photodetector based on p‐P3HT/n‐ZnO nanowire array heterojunction is demonstrated, which exhibits photoconductive gain of 4.2 × 10−4, responsivity of 125 µA W−1, specific detectivity of 3.7 × 107 Jones, and response/recovery speed of less than 100 ms at a low light intensity of 0.84 mW cm−2 for λ = 365 nm. The responsivity of this photodetector can be further enhanced by ≈21.9% under a temperature difference of −15.4 °C, owing to the thermo‐phototronic effect. Moreover, a photodetector array with 16 pixels is successfully demonstrated for light imaging of complex patterns, such as number‐shape and cross‐shape. This study provides a practical solution to achieve large‐scale UV imaging by integrating inorganic–organic hybrid photodetector into self‐powered array configuration.
Bioinspired Anti‐Moiré Random Grids via Patterning Foams
Authors: Li Zheng , Huang Zhandong , Yang Qiang , Su Meng , Zhou Xue , Li Huizeng , Li Lihong , Li Fengyu , Song Yanlin 
Published: October 2017

AbstractTransparent conductors with specific patterns are essential for touch screens as sensing electrodes. Among them, metal grids are a kind of optimal alternative for traditional transparent conductors, while moiré patterns hinder metal grids in the application of display planes. Nevertheless, random or aperiodic pattern grids can avoid the patterns. A series of bioinspired random (BR) grids is demonstrated that can avoid moiré patterns and exhibit great optoelectronic performance comparable to indium tin oxide (ITO). The BR grids comprising random hexagons originate from biological networks with line arrangements that are random and aperiodic. They are fabricated through a controllable and highly efficient method of patterning foams, and are composed of close‐packed silver nanoparticles (AgNPs). This type of grid has potential to extend applications of high‐transparent functional devices.
The Next‐Generation of Nonlinear Optical Materials: Rb3Ba3Li2Al4B6O20F—Synthesis, Characterization, and Crystal Growth
Authors: Yu Hongwei , Young Joshua , Wu Hongping , Zhang Weiguo , Rondinelli James M. , Halasyamani Shiv 
Published: October 2017

AbstractNonlinear optical (NLO) materials are of intense academic and technological interest attributable to their ability to generate coherent radiation over a range of different wavelengths. The requirements for a viable NLO material are rather strict, and their discovery has mainly been serendipitous. This study reports synthesis, characterization, and, most importantly, growth of large single crystals of a technologically viable NLO material—Rb3Ba3Li2Al4B6O20F. Through the judicious selection of cations, Rb3Ba3Li2Al4B6O20F exhibits a 3D structure that facilitates the growth of large single crystals along the optical axis direction. Measurements on these crystals indicate that Rb3Ba3Li2Al4B6O20F exhibits a moderate birefringence of 0.057 at 1064 nm enabling Type I phase‐matching down to 243 nm. Theoretical calculations indicate the symmetry adapted mode displacement (SAMD) parameter scales with the second‐harmonic generation intensity.
Iridium‐Catalyzed Regio‐ and Stereoselective C‐H Oxidative Reaction to (Z)‐3‐Arylidene‐2‐oxindole Imides under Neutral Conditions
Authors: Tu Zhikai , Tan Jie , Chen Zhiyuan , Tu Tao 
Published: October 2017

AbstractUnsymmetrical 3‐arylidene‐2‐oxindoles are useful pharmacophores for many clinical drugs or intermediates in alkaloids synthesis. An IridiumIII‐catalyzed sequential C−H oxidative reaction of 2‐indolyl enamides has been established. This protocol utilized α,α‐dimethyl benzylhydroperoxide as the oxidant and silver fluoride as a key promoter, to provide a wide range of (Z)‐3‐arylidene‐2‐oxindole imides in moderate to good yields, together with good regio‐ and stereoselectivity. The silver fluoride was found to function as a base to facilitate the generation of the active Iridium catalyst species. The resulting (Z)‐3‐arylidene‐2‐oxindole imides could be further transformed to various valuable derivatives. Mechanistically, radical‐process was excluded from this C−H oxidative transformation, and a 6‐membered cationic iridacycle intermediate was proposed to be involved in the catalytic cycle.magnified image
1(3)‐Formyl‐β‐carbolines: Potential Aldo‐X Precursors for the Synthesis of β‐Carboline‐Based Molecular Architectures
Authors: Devi Nisha , Kumar Sunit , Pandey Satyendra Kumar , Singh Virender 
Published: October 2017

Abstractβ‐Carboline, a privileged scaffold in the alkaloid family, has a broad spectrum of medicinal properties and is found in several commercial drugs, such as tadalafil, cipargamin, and abecarnil. Owing to the immense pharmacological importance of β‐carboline derivatives, their synthesis has been one of the frontier areas of research in recent years. In this context, 1(3)‐formyl‐9H‐β‐carbolines are promising “aldo‐X” bifunctional building blocks (AXB3s) that offer alternate avenues for the diversity‐oriented synthesis of β‐carboline derivatives. This Focus Review is an assimilation of recent literature (2011–2017) pertaining to the synthesis and applications of 1(3)‐formyl‐β‐carbolines for the construction of β‐carboline‐tethered and ‐fused molecular architectures. In addition, the medicinal potential of β‐carboline derivatives has been highlighted.
Pd‐Catalyzed Cyclopropanation Reaction of Aliphatic Ketones with Monosubstituted Allyl Reagents
Authors: Huang Jian‐Qiang , Zhao Jing‐Feng , Yang Zhen , Ding Chang‐Hua , Hou Xue‐Long , Peng Xiao‐Shui , Wong Henry Nai Ching 
Published: October 2017

AbstractA Pd‐catalyzed cyclopropanation reaction with aliphatic ketones as nucleophiles using a modified pyridine‐NHC ligand was achieved. The reaction afforded the corresponding cyclopropanes in moderate to good yields with high cyclopropane/allylation selectivity.
Stroke‐induced chronic systolic dysfunction driven by sympathetic overactivity
Authors: Bieber Michael , Werner Rudolf A. , Tanai Edit , Hofmann Ulrich , Higuchi Takahiro , Schuh Kai , Heuschmann Peter U. , Frantz Stefan , Ritter Oliver , Kraft Peter , Kleinschnitz Christoph 
Published: October 2017

ObjectiveCardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease are incompletely understood. Although it is established that ischemic stroke is associated with cardiac arrhythmias, myocardial damage, elevated cardiac enzymes, and plasma catecholamines in the acute phase, nothing is known about the delayed consequences of ischemic stroke on cardiovascular function.MethodsTo determine the long‐term cardiac consequences of a focal cerebral ischemia, we subjected young and aged mice to a 30‐minute transient middle cerebral artery occlusion and analyzed cardiac function by serial transthoracic echocardiography and hemodynamic measurements up to week 8 after surgery. Finally, animals were treated with metoprolol to evaluate a pharmacologic treatment option to prevent the development of heart failure.ResultsFocal cerebral ischemia induced a long‐term cardiac dysfunction with a reduction in left ventricular ejection fraction and an increase in left ventricular volumes; this development was associated with higher peripheral sympathetic activity. Metoprolol treatment prevented the development of chronic cardiac dysfunction by decelerating extracellular cardiac remodeling and inhibiting sympathetic signaling relevant to chronic autonomic dysfunction.InterpretationFocal cerebral ischemia in mice leads to the development of chronic systolic dysfunction driven by increased sympathetic activity. If these results can be confirmed in a clinical setting, treating physicians should be attentive to clinical signs of heart failure in every patient after ischemic stroke. Therapeutically, the successful β‐blockade with metoprolol in mice could also have future clinical implications. Ann Neurol 2017;82:729–743
Das Cysteinom der Proteinkinasen als Zielstruktur in der Arzneistoffentwicklung
Authors: Chaikuad Apirat , Koch Pierre , Laufer Stefan A. , Knapp Stefan 
Published: October 2017

AbstractWirkstoffe, die ihre Wirkung über die Ausbildung einer kovalenten Bindung entfalten, repräsentieren einen beachtlichen Anteil unseres Arsenals an effektiven Arzneistoffen. Allerdings wurde die aufwendige Entwicklung kovalenter Inhibitoren wegen Sicherheitsbedenken bis vor kurzem nur als eine wenig attraktive Strategie im rationalen Wirkstoffdesign angesehen. Die kürzliche Zulassung von vier kovalenten Kinaseinhibitoren und die Entwicklung hochpotenter kovalenter Kinasehemmstoffe mit bemerkenswerter Selektivität erhöhte das Interesse in der industriellen und akademischen Forschung maßgeblich und bestätigte das Konzept der kovalenten Kinasehemmung für klinische Anwendungen. Die Häufigkeit von Cysteinen an verschiedenen Positionen innerhalb und in der Nähe des aktiven Zentrums legt nahe, dass ein wesentlicher Teil der Kinasen durch kovalente Inhibitoren adressiert werden kann. In diesem Aufsatz geben wir eine Übersicht über die neuesten Entwicklungen in diesem schnell wachsenden Gebiet und heben die einzigartigen Möglichkeiten und Herausforderungen dieser Strategie hervor.
Effects of Bithiophene Imide Fusion on the Device Performance of Organic Thin‐Film Transistors and All‐Polymer Solar Cells
Authors: Wang Yingfeng , Yan Zhenglong , Guo Han , Uddin Mohammad Afsar , Ling Shaohua , Zhou Xin , Su Huimin , Dai Junfeng , Woo Han Young , Guo Xugang 
Published: October 2017

AbstractTwo new bithiophene imide (BTI)‐based n‐type polymers were synthesized. f‐BTI2‐FT based on a fused BTI dimer showed a smaller band gap, a lower LUMO, and higher crystallinity than s‐BTI2‐FT containing a BTI dimer connected through a single bond. s‐BTI2‐FT exhibited a remarkable electron mobility of 0.82 cm2 V−1 s−1, and f‐BTI2‐FT showed a further improved mobility of 1.13 cm2 V−1 s−1 in transistors. When blended with the polymer donor PTB7‐Th, f‐BTI2‐FT‐based all‐polymer solar cells (all‐PSCs) attained a PCE of 6.85 %, the highest value for an all‐PSC not based on naphthalene (or perylene) diimide polymer acceptors. However, s‐BTI2‐FT all‐PSCs showed nearly no photovoltaic effect. The results demonstrate that f‐BTI2‐FT is one of most promising n‐type polymers and that ring fusion offers an effective approach for designing polymers with improved electrical properties.
Selektive C‐H‐Bindungsaktivierung durch eine Kaskade aus Photochemie und Biokatalyse
Authors: Zhang Wuyuan , Burek Bastien O. , Fernández‐Fueyo Elena , Alcalde Miguel , Bloh Jonathan Z. , Hollmann Frank 
Published: October 2017

AbstractSelektive Oxyfunktionalisierungen von inerten C‐H‐Bindungen können unter milden Bedingungen durch den Einsatz von Peroxygenasen erreicht werden. Dieser Ansatz wird jedoch durch die schlechte Stabilität der Enzyme in Anwesenheit stöchiometrischer Mengen des Oxidationsmittels Wasserstoffperoxid erschwert. Hier zeigen wir, dass sich anorganische Photokatalysatoren wie goldbeladenes Titandioxid zur effizienten Bereitstellung geeigneter Mengen an H2O2 durch reduktive Aktivierung von Umgebungssauerstoff und simultaner Oxidation von Methanol eignen und gleichzeitig eine hohe Reaktivität und Stabilität des Enzyms gewährleisten. Mithilfe dieses Ansatzes konnte die stereoselektive Hydroxylierung von Ethylbenzol zu (R)‐1‐Phenylethanol in hoher Enantioselektivität (>98 % ee) und sehr hoher katalytischer Produktivität (TON>71.000) erreicht werden.
Electrostatic‐Assisted Liquefaction of Porous Carbons
Authors: Li Peipei , Schott Jennifer A. , Zhang Jinshui , Mahurin Shannon M. , Sheng Yujie , Qiao Zhen‐An , Hu Xunxiang , Cui Guokai , Yao Dongdong , Brown Suree , Zheng Yaping , Dai Sheng 
Published: October 2017

AbstractPorous liquids are a newly developed porous material that combine unique fluidity with permanent porosity, which exhibit promising functionalities for a variety of applications. However, the apparent incompatibility between fluidity and permanent porosity makes the stabilization of porous nanoparticle with still empty pores in the dense liquid phase a significant challenging. Herein, by exploiting the electrostatic interaction between carbon networks and polymerized ionic liquids, we demonstrate that carbon‐based porous nanoarchitectures can be well stabilized in liquids to afford permanent porosity, and thus opens up a new approach to prepare porous carbon liquids. Furthermore, we hope this facile synthesis strategy can be widely applicated to fabricate other types of porous liquids, such as those (e.g., carbon nitride, boron nitride, metal–organic frameworks, covalent organic frameworks etc.) also having the electrostatic interaction with polymerized ionic liquids, evidently advancing the development and understanding of porous liquids.
Dimethylamin als Substrat in Hydroaminoalkylierungsreaktionen
Authors: Bielefeld Jens , Doye Sven 
Published: October 2017

AbstractÜbergangsmetallkatalysierte Hydroaminoalkylierungen von Alkenen haben im vergangenen Jahrzehnt große Fortschritte gemacht und entwickeln sich zu einer greifbaren Alternative zur industriellen Synthese von Aminen durch Hydroformylierung von Alkenen und nachfolgende reduktive Aminierung. Ein großes Hindernis war in der Vergangenheit, dass Methylamin und Dimethylamin als industriell wichtigste Amine in diesen Reaktionen nicht zufriedenstellend umgesetzt werden konnten. Wir zeigen hier erstmals die erfolgreiche Umsetzung von Dimethylamin in katalytischen Hydroaminoalkylierungen von Alkenen mit guten Ausbeuten, sowie die Anwendbarkeit für eine Reihe verschiedener Alkene und die Toleranz gegenüber verschiedenen funktionellen Gruppen. Zusätzlich präsentieren wir die katalytische Dihydroaminoalkylierungsreaktion mit Dimethylamin, über die nie zuvor berichtet wurde.
Catalytic Enantioselective Synthesis of Mariline A and Related Isoindolinones through a Biomimetic Approach
Authors: Min Chang , Lin Yingfu , Seidel Daniel 
Published: October 2017

AbstractThe catalytic enantioselective synthesis of isoindolinones was achieved through the condensation of 2‐acyl‐benzaldehydes and anilines. In the presence of 1 mol % of a chiral phosphoric acid catalyst, reactions reach completion within 10 min and provide products with up to 98 % ee. Anilines with an ortho t‐butyl group form atropisomeric products, thereby enabling the simultaneous generation of axial and point chirality from two achiral substrates. This method was applied to the first synthesis of mariline A.
Lithium Azide as an Electrolyte Additive for All‐Solid‐State Lithium–Sulfur Batteries
Authors: Eshetu Gebrekidan Gebresilassie , Judez Xabier , Li Chunmei , Bondarchuk Oleksandr , Rodriguez‐Martinez Lide M. , Zhang Heng , Armand Michel 
Published: October 2017

AbstractOf the various beyond‐lithium‐ion battery technologies, lithium–sulfur (Li–S) batteries have an appealing theoretical energy density and are being intensely investigated as next‐generation rechargeable lithium‐metal batteries. However, the stability of the lithium‐metal (Li°) anode is among the most urgent challenges that need to be addressed to ensure the long‐term stability of Li–S batteries. Herein, we report lithium azide (LiN3) as a novel electrolyte additive for all‐solid‐state Li–S batteries (ASSLSBs). It results in the formation of a thin, compact and highly conductive passivation layer on the Li° anode, thereby avoiding dendrite formation, and polysulfide shuttling. It greatly enhances the cycling performance, Coulombic and energy efficiencies of ASSLSBs, outperforming the state‐of‐the‐art additive lithium nitrate (LiNO3).
Mild Reduction of Phosphine Oxides with Phosphites To Access Phosphines
Authors: Li Peng , Wischert Raphael , Métivier Pascal 
Published: October 2017

AbstractA new method for the iodine‐catalyzed reduction of phosphine oxides with phosphites at room temperature is reported. The mild reaction conditions, scalability, and simple purification requirements render it a method of choice for the large‐scale production and facile regeneration of a variety of phosphines. Mechanistic studies, supported by DFT calculations of the oxygen transfer between the starting phosphine oxide and the phosphite reagent, are also presented. Such transmutations of phosphorus species were previously unknown.
Decoupled Thermo‐ and pH‐Responsive Hydrogel Microspheres Cross‐Linked by Rotaxane Networks
Authors: Kureha Takuma , Aoki Daichi , Hiroshige Seina , Iijima Keisuke , Aoki Daisuke , Takata Toshikazu , Suzuki Daisuke 
Published: October 2017

AbstractRotaxane cross‐linked (RC) microgels that exhibit a decoupled thermo‐ and pH‐responsive volume transition were developed. The pH‐induced changes of the aggregation/disaggregation states of cyclodextrin in the RC networks were used to control the swelling capacity of the entire microgels. Different from conventional thermo‐ and pH‐responsive microgels, which are usually obtained from copolymerizations involving charged monomers, the RC microgels respond to temperature as intended, even in the presence of charged functional molecules such as dyes in the microgel dispersion. The results of this study should lead to new applications, including drug delivery systems that require a retention of their smart functions even in environments that may contain foreign ions, for example, in in vivo experiments.