bluuebunny/crossref_metadata_2025_split huggingface dataset:
FIVE-YEAR FOLLOW-UP AFTER EPIRETINAL MEMBRANE SURGERY
Authors: Fleissig Efrat , Zur Dinah , Moisseiev Elad , Keren Shay , Ohana Oded , Barak Adiel 
Published: May 2017

Purpose:
To evaluate the rate of epiretinal membrane (ERM) recurrence in eyes that underwent ERM peeling surgery at least 5 years earlier.

Methods:
Retrospective interventional case series study of 37 patients (15 women and 22 men; mean age, 70 ± 7.6 years) operated on for ERM removal with a follow-up of at least 5 years. The patients underwent testing for visual acuity, an ophthalmic examination, and optical coherence tomography imaging, all of which were assessed preoperatively, postoperatively, and at the 5-year follow-up.

Results:
Visual acuity significantly improved at 1 year after peeling compared with baseline (P = 0.045), and the improved results were maintained at 5 years (P = 0.804) 0.766 logarithm of the minimum angle of resolution (Snellen 6/35). The central macular thickness decreased significantly at the 1-year follow-up compared with baseline and continued to decrease as measured at the 5-year follow-up (P = 0.04). At 5 years, the ERM recurrence rate reached 58% (28% extrafoveal). Photoreceptor atrophy and retinal pigment epithelium changes correlated with diabetes mellitus (P = 0.028).

Conclusion:
The recurrence rate of ERM after peeling surgery was reported as being around 5% to 12%. It was 58% in the current study. Because the recurrent ERM is generally mild, visual acuity was unaffected.
MULTIMODAL IMAGING OF ACUTE EXUDATIVE POLYMORPHOUS VITELLIFORM MACULOPATHY WITH OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY AND ADAPTIVE OPTICS SCANNING LASER OPHTHALMOSCOPY
Authors: Skondra Dimitra , Nesper Peter L. , Fawzi Amani A. 
Published: May 2017

Purpose:
To report a case of acute exudative polymorphous vitelliform maculopathy including the findings of optical coherence tomography angiography and adaptive optics scanning laser ophthalmoscopy.

Methods:
Findings on clinical examination, color fundus photography, spectral-domain optical coherence tomography, infrared reflectance, autofluorescence, optical coherence tomography angiography, and adaptive optics scanning laser ophthalmoscopy.

Results:
A 54-year-old white man with no significant medical history and history of smoking presented with bilateral multiple serous and vitelliform detachments consistent with acute exudative polymorphous vitelliform maculopathy. Extensive infectious, inflammatory, and malignancy workup was negative. Spectral-domain optical coherence tomography showed thickened, hyperreflective ellipsoid zone, subretinal fluid, and focal as well as diffuse subretinal hyperreflective material corresponding to the vitelliform lesions. Optical coherence tomography angiography showed normal retinal and choroidal vasculature, whereas adaptive optics scanning laser ophthalmoscopy showed circular focal “target” lesions at the level of the photoreceptors in the area of foveal detachment.

Conclusion:
Multimodal imaging is valuable in evaluating patients with acute exudative polymorphous vitelliform maculopathy.
Are Perioperative Bundles Associated With Reduced Postoperative Morbidity in Women Undergoing Benign Hysterectomy? Retrospective Cohort Analysis of 16,286 Cases in Michigan
Authors: Harris John A. , Sammarco Anne G. , Swenson Carolyn W. , Uppal Shitanshu , Kamdar Neil , Campbell Darrel , Evilsizer Sarah , DeLancey John O. , Morgan Daniel M. 
Published: May 2017

(Abstracted from Am J Obstet Gynecol 2017;216:502.e1–502.e11)
In the past decade, team-based interventions such as checklists and bundle processes have been shown to improve health care outcomes.
Outcome of Patients With Advanced Ovarian Cancer Who Do Not Undergo Debulking Surgery: A Single Institution Retrospective Review
Authors: Marchetti Claudia , Kristeleit Rebecca , McCormack Mary , Mould Tim , Olaitan Adeola , Widschwendter Martin , MacDonald Nicola , Ledermann Jonathan A. 
Published: May 2017

(Abstracted from Gynecol Oncol 2017;144:57–60)
The cornerstone of ovarian cancer (OC) treatment is debulking surgery to remove all residual disease. Recommended treatment for advanced OC (FIGO [International Federation of Gynecology and Obstetrics] III–IV) is optimal primary debulking surgery followed by platinum-based chemotherapy.
Approach to adenovirus infections in the setting of hematopoietic cell transplantation
Authors: Lee Yeon Joo , Prockop Susan E. , Papanicolaou Genovefa A. 
Published: May 2017

Purpose of review
To review risk-based pre-emptive treatment for adenovirus (ADV) based on quantitative PCR (qPCR) and to provide an update on clinical trials of brincidofovir (BCV) and ADV-specific cytotoxic T lymphocytes (ADV-CTLs).

Recent findings
ADV qPCR in various body compartments enables distinction of clinically significant infection and assessment of treatment responses. Plasma ADV qPCR monitoring and aggressive pre-emptive treatment is recommended for high-risk patients. Pre-emptive therapy at low viral load is associated with faster virologic response and improved outcomes. BCV has demonstrated virologic responses against all clinically significant ADV serotypes. Prolonged administration of oral BCV may be limited by gastrointestinal toxicity; an intravenous BCV formulation does not show gastrointestinal toxicity in early studies. ADV-CTLs can be generated from ADV-seropositive individuals using a variety of systems. Banked ADV-CTLs can achieve durable responses in patients for whom no donor-derived cell therapy product is available.

Summary
Disseminated ADV disease is associated with substantial mortality in hematopoietic cell transplant recipients. Routine monitoring by plasma ADV qPCR and pre-emptive therapy at low viral load are associated with improved outcomes in high-risk patients. BCV and ADV-CTLs are promising modalities currently undergoing clinical trials.
Diagnostic Yield of Routine Electroencephalography With Concurrent Video Recording in Detecting Interictal Epileptiform Discharges in Relation to Reasons for Request: A Prospective Study of 1,080 Video-Electroencephalograms
Authors: Grau-López Laia , Jiménez Marta , Ciurans Jordi , Barambio Sonia , Fumanal Alejandra , Becerra Juan L. 
Published: May 2017

Purpose:
The aim of this study was to prospectively analyze the sensitivity and specificity of routine electroencephalography with concurrent video recording (vEEG) in relation to the reasons for requesting the test and to investigate when routine vEEG should be requested.

Methods:
We prospectively analyzed 1,080 consecutive vEEGs performed between April 2015 and April 2016. The requests for vEEG were classified as requests with a low suspicion of epilepsy (syncope, confusion or delirium, suspicion of psychogenic nonepileptic seizures, and paroxysmal focal neurological deficit) or requests with a high suspicion of epilepsy (first clinical seizure, suspected status epilepticus, follow-up study of a patient with epilepsy, and acute symptomatic seizures). Predominant vEEG findings (ictal and interictal epileptiform activities, diffuse, or focal slowing and triphasic waves) were analyzed, and sensitivity and specificity ​​values calculated.

Results:
The most common indication for vEEG was a follow-up study of patients with epilepsy (38%), followed by first clinical seizure (19.3%) and suspected status epilepticus (11%). The respective specificity and sensitivity values were 93% and 58% for 235 vEEGs performed in children/adolescents (≤18 years), 95% and 40% for 533 vEEGs performed in adults (>18 ≤ 65 years), and 93% and 39% for 312 vEEGs performed in older adults (>65 years). Twenty-four patients with false-positive paroxysms had a clinical diagnosis of confusional state or paroxysmal focal neurological deficit. Neurologists and neuropediatricians with experience in managing epilepsy had higher specificity values than general neurologists or physicians (P = 0.012).

Conclusions:
In our series, vEEG abnormalities were mainly observed in patients with clinical findings highly suggestive of epilepsy. In confusional states, and paroxysmal focal neurological deficit vEEG could be indicated.
Operculo-Insular Epilepsy: Scalp and Intracranial Electroencephalographic Findings
Authors: Levy Ariel , Yen Tran Thi Phuoc , Boucher Olivier , Bouthillier Alain , Nguyen Dang Khoa 
Published: May 2017

Purpose:
Operculo-insular seizures are heterogeneous and may resemble seizures originating from the temporal, frontal, or parietal lobe. Although surface and invasive EEG recordings are often necessary to detect operculo-insular seizures, electrophysiological features of operculo-insular epilepsies remain poorly characterized. This study describes the EEG findings of patients with operculo-insular epilepsy.

Methods:
We reviewed electrophysiological data of all patients (n = 9) with operculo-insular seizures revealed by intracranial EEG and for whom operculo-insular epilepsy was confirmed by good seizure outcome after resective or radiosurgery at our center between 2005 and 2013. Patients were divided according to whether their seizure focus involved the anterior (group 1; n = 4) or posterior (group 2; n = 5) portion of the insula.

Results:
Interictal scalp EEG was lateralizing and showed distinct topographical spike patterns between groups: frontal and temporal in group 1, temporal in group 2. Intracranial recordings showed abundant spikes limited to the operculo-insular region or involving distant areas in the frontal/temporal (group 1) and temporal/parietal lobes (group 2). Ictal intracranial EEG revealed discharges limited to the insula or simultaneously involving extrainsular contacts at onset, notably the orbitofrontal cortex (group 1) and the frontal and parietal opercula (group 2), and propagating to the frontal and temporal lobes in group 1 and to parietal and temporal lobes in group 2.

Conclusions:
Spike distribution and seizure propagation in operculo-insular epilepsy follows an anterior-to-posterior pattern mirroring an anterior or posterior insular focus localization. When presented with frontal and/or temporal epileptiform abnormalities, an operculo-insular focus should be considered.
Isotocin neuronal phenotypes differ among social systems in cichlid fishes
Authors: Reddon Adam R. , O'Connor Constance M. , Nesjan Erin , Cameron Jason , Hellmann Jennifer K. , Ligocki Isaac Y. , Marsh-Rollo Susan E. , Hamilton Ian M. , Wylie Douglas R. , Hurd Peter L. , Balshine Sigal 
Published: May 2017

Social living has evolved numerous times across a diverse array of animal taxa. An open question is how the transition to a social lifestyle has shaped, and been shaped by, the underlying neurohormonal machinery of social behaviour. The nonapeptide neurohormones, implicated in the regulation of social behaviours, are prime candidates for the neuroendocrine substrates of social evolution. Here, we examined the brains of eight cichlid fish species with divergent social systems, comparing the number and size of preoptic neurons that express the nonapeptides isotocin and vasotocin. While controlling for the influence of phylogeny and body size, we found that the highly social cooperatively breeding species (
n
= 4) had fewer parvocellular isotocin neurons than the less social independently breeding species (
n
= 4), suggesting that the evolutionary transition to group living and cooperative breeding was associated with a reduction in the number of these neurons. In a complementary analysis, we found that the size and number of isotocin neurons significantly differentiated the cooperatively breeding from the independently breeding species. Our results suggest that isotocin is related to sociality in cichlids and may provide a mechanistic substrate for the evolution of sociality.
Unbiased emission factor estimators for large scale forest inventories: domain assessment techniques
Authors: Birigazzi Luca , Gamarra Javier G. P. , Gregoire Timothy G. 
Published: May 2017

AbstractLarge scale forest inventories are often undertaken following a stratified random or systematic design. Yet the strata rarely correspond to the reporting areas of interest (domains) over which the country wants to report specific variables. The process is exemplified by a country aiming to use national forest inventory data to obtain average biomass estimates per forest type for GHGI international reporting, where activity data (areas of land use or land use changes) and emission factors (carbon coefficients) are typically compiled from disparate sources and estimated using different sampling schemes. This study aims to provide a decision tree for the use of data obtained from forest surveys to draw conclusions about population sub-groups created after (and independently of) the sample selection. While bias can arise whenever activity data and emission factors are calculated independently, it can be eliminated in case of a simple random or simple systematic design if properly weighted estimators are provided. This manuscript describes two unbiased estimators that can be used to estimate reporting-strata means, regardless of the sampling design adopted, and extends the result to the common situation in which the reporting-strata are spatially explicit, where a nested group estimator outperforms in terms of both bias and precision other more traditional estimators. From this estimator, an optimal sample allocation scheme is also derived.
Prediction of fluoroquinolone susceptibility directly from whole genome sequence data using liquid chromatography-tandem mass spectrometry to identify mutant genotypes
Authors: Wan Nur Ismah Wan Ahmad Kamil , Takebayashi Yuiko , Findlay Jacqueline , Heesom Kate J. , Jiménez-Castellanos Juan-Carlos , Zhang Jay , Graham Lee , Bowker Karen , Williams O. Martin , MacGowan Alasdair P. , Avison Matthew B. 
Published: May 2017

ABSTRACTFluoroquinolone resistance in bacteria is multifactorial, involving target site mutations, reductions in fluoroquinolone entry due to reduced porin production, increased fluoroquinolone efflux, enzymes that modify fluoroquinolones, and Qnr, a DNA mimic that protects the drug target from fluoroquinolone binding. Here we report a comprehensive analysis using transformation and in vitro mutant selection, of the relative importance of each of these mechanisms in fluoroquinolone resistance and non-susceptibility, usingKlebsiella pneumoniae, one of the most clinically important multi-drug resistant bacterial species known, as a model system. Our improved biological understanding was then used to generate rules that could be predict fluoroquinolone susceptibility inK. pneumoniaeclinical isolates. Key to the success of this predictive process was the use of liquid chromatography tandem mass spectrometry to measure the abundance of proteins in extracts of cultured bacteria, identifying which sequence variants seen in the whole genome sequence data were functionally important in the context of fluoroquinolone susceptibility.
Prediction of cephalosporin and carbapenem susceptibility in multi-drug resistant Gram-negative bacteria using liquid chromatography-tandem mass spectrometry
Authors: Takebayashi Yuiko , Wan Nur Ismah Wan Ahmad Kamil , Findlay Jacqueline , Heesom Kate J. , Zhang Jay , Williams O. Martin , MacGowan Alasdair P. , Avison Matthew B. 
Published: May 2017

ABSTRACTIn vitro antibacterial susceptibility testing informs clinical decision making concerning antibacterial therapeutics. Predicting, in a timely manner, which bacterial infection will respond to treatment by a given antibacterial drug reduces morbidity, mortality, and healthcare costs. It also allows prudent antibacterial use, because clinicians can focus on the least broad-spectrum agent suitable for each patient. Existing susceptibly testing methodologies rely on growth of bacteria in the presence of an antibacterial drug. There is significant interest in the possibility of predicting antibacterial drug susceptibility directly though the analysis of bacterial DNA or protein, because this may lead to more rapid susceptibility testing directly from clinical samples. Here we report a robust and tractable methodology that allows measurement of the abundance of key proteins responsible for antibacterial drug resistance within samples of 1 µg of total bacterial protein. The method allowed correct prediction of β-lactam susceptibility in clinical isolates from four key bacterial species and added considerable value over and above the information generated by whole genome sequencing, allowing for gene expression, not just gene presence to be considered, which is key when considering the complex interplays of multiple mechanisms of resistance.
A small RNA pathway mediates global allelic dosage in endosperm
Authors: Erdmann Robert M. , Satyaki P.R. V. , Klosinska Maja , Gehring Mary 
Published: May 2017

SummaryBalance between maternal and paternal genomes within the triploid endosperm is necessary for normal seed development. The majority of genes in Arabidopsis endosperm are expressed in a 2:1 maternal:paternal ratio, reflecting endosperm genomic DNA content. Here we find that the 2:1 transcriptional ratio is not, unexpectedly, a passive default but is actively regulated. We describe an inverse relationship between the parent-of-origin of small RNAs and mRNAs in endosperm on a genome-wide scale. Disruption of the Pol IV small RNA pathway causes the entire transcriptome to become more maternally biased. Furthermore, paternal inheritance of a RNA Pol IV mutation is sufficient to rescue seed abortion caused by excess paternal genome dosage. These results indicate that maintenance of the maternal:paternal transcriptome ratio in endosperm is an active process and reveal a function for RNA Pol IV in mediating the global transcriptional balance between maternally and paternally inherited genomes in endosperm.
A cyber-anima-based model of material conscious information network
Authors: Shen Jianping , Huang Yadong , Chai Yueting 
Published: May 2017

Purpose
This paper aims to study the node modeling, multi-agent architecture and addressing method for the material conscious information network (MCIN), which is a large-scaled, open-styled, self-organized and ecological intelligent network of supply–demand relationships.

Design/methodology/approach
This study models the MCIN by node model definition, multi-agent architecture design and addressing method presentation.

Findings
The prototype of novel E-commerce platform based on the MCIN shows the effectiveness and soundness of the MCIN modeling. By comparing to current internet, the authors also find that the MCIN has the advantages of socialization, information integration, collective intelligence, traceability, high robustness, unification of producing and consuming, high scalability and decentralization.

Research limitations/implications
Leveraging the dimensions of structure, character, knowledge and experience, a modeling approach of the basic information can fit all kinds of the MCIN nodes. With the double chain structure for both basic and supply–demand information, the MCIN nodes can be modeled comprehensively. The anima-desire-intention-based multi-agent architecture makes the federated agents of the MCIN nodes self-organized and intelligent. The MCIN nodes can be efficiently addressed by the supply–demand-oriented method. However, the implementation of the MCIN is still in process.

Practical implications
This paper lays the theoretical foundation for the future networked system of supply–demand relationship and the novel E-commerce platform.

Originality/value
The authors believe that the MCIN, first proposed in this paper, is a transformational innovation which facilitates the infrastructure of the future networked system of supply–demand relationship.
Crowd wisdom drives intelligent manufacturing
Authors: Lu Jiaqi , Liu Shijun , Cui Lizhen , Pan Li , Wu Lei 
Published: May 2017

Purpose
A fundamental problem for intelligent manufacturing is to equip the agents with the ability to automatically make judgments and decisions. This paper aims to introduce the basic principle for intelligent crowds in an attempt to show that crowd wisdom could help in making accurate judgments and proper decisions. This further shows the positive effects that crowd wisdom could bring to the entire manufacturing process.

Design/methodology/approach
Efforts to support the critical role of crowd wisdom in intelligent manufacturing involve theoretical explanation, including a discussion of several prevailing concepts, such as consumer-to-business (C2B), crowdfunding and an interpretation of the contemporary Big Data mania. In addition, an empirical study with three business cases was conducted to prove the conclusion that our ideas could well explain the current business phenomena and guide the future of manufacturing.

Findings
This paper shows that crowd wisdom could help make accurate judgments and proper decisions. It further shows the positive effects that crowd wisdom could bring to the entire manufacturing process.

Originality/value
The paper highlights the importance of crowd wisdom in manufacturing with sufficient theoretical and empirical analysis, potentially providing a guideline for future industry.
Experimental results on large-scale cyber-physical hybrid discussion support
Authors: Ito Takayuki , Otsuka Takanobu , Kawase Satoshi , Sengoku Akihisa , Shiramatsu Shun , Ito Takanori , Hideshima Eizo , Matsuo Tokuro , Oishi Tetsuya , Fujita Rieko , Fukuta Naoki , Fujita Katsuhide 
Published: May 2017

Purpose
This paper aims to present a preliminary experimental result on a large-scale experiment on a cyber-physical hybrid discussion support environment in a panel discussion session in an international conference.

Design/methodology/approach
In this paper, the authors propose a hybrid (cyber-physical) environment in which people can discuss online and also offline simultaneously. The authors conducted a large-scale experiment in a panel discussion session in an international conference where participants can discuss by using their online discussion support system and by physical communications as usual.

Findings
The authors analyzed the obtained date from the following three viewpoints: participants’ cyber-physical attention, keywords cyber-physical linkage and cyber-physical discussion flow. These three viewpoints indicate that the methodology of the authors can be effective to support hybrid large-scale discussions.

Originality/value
Online large-scale discussion has been focused as a new methodology that enable people to discuss, argue and make consensus in terms of political issues, social complex problems (like climate change), city planning and so on. In several cases, the authors found that online discussions are very effective to gather people opinions and discussions so far. Moreover, this paper proposes a hybrid (cyber-physical) environment in which people can discuss online and also offline simultaneously.
Crowd science and engineering: concept and research framework
Authors: Chai Yueting , Miao Chunyan , Sun Baowen , Zheng Yongqing , Li Qingzhong 
Published: May 2017

Purpose
The synthetic application and interaction of/between the internet, Internet of Things, cloud computing, big data, Industry 4.0 and other new patterns and new technologies shall breed future Web-based industrial operation system and social operation management patterns, manifesting as a crowd cyber eco-system composed of multiple interconnected intelligent agents (enterprises, individuals and governmental agencies) and its dynamic behaviors. This paper aims to explore the basic principles and laws of such a system and its behavior.

Design/methodology/approach
The authors propose the concepts of crowd science and engineering (CSE) and expound its main content, thus forming a research framework of theories and methodologies of crowd science.

Findings
CSE is expected to substantially promote the formation and development of crowd science and thus lay a foundation for the advancement of Web-based industrial operation system and social operation management patterns.

Originality/value
This paper is the first one to propose the concepts of CSE, which lights the beacon for the future research in this area.