bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cellular automata modelling to simulate patterns of urban growth for Nusantara: Indonesia’s new capital
Authors: Arfiansyah Dody , Hawken Scott , Zlatanova Sisi , Han Hoon 
Published: October 2024

AbstractThis paper uses cellular automata (CA) modelling to simulate possible patterns of urban growth for Nusantara–Indonesia’s new capital. The modelling uses criteria such as projected population growth and planned development stages and a range of relevant factors that influence urban development. Further the study simulates the possible impact of future urban growth on key biodiversity areas (KBAs). Two scenarios were modelled to simulate urban growth patterns–(1) the nature sensitive city and (2) the Indonesian government’s current plan. Results of the scenario-based CA modelling demonstrate that scenario 1 offers a more sustainable and liveable approach to urban growth, despite its larger land footprint. This is achieved by preserving protected and key biodiversity areas, which are essential for the long-term well-being and resilience of the environment. While scenario 2 is more land-efficient, it presents a possible risk to the overall ecological integrity and liveability of the metropolis by impinging into key biodiversity areas. The study’s cellular automata approach and methodology can be employed for urban planning and biodiversity impact assessment in similar contexts of new city development.
A Comprehensive Review of the Occurrence, Distribution, Characteristics and Fate of Per- and Polyfluoroalkyl Substances in the African Continent
Authors: Umejuru Emmanuel Christopher , Street Renee , Edokpayi Joshua N. 
Published: October 2024

AbstractPer- and polyfluoroalkyl substances (PFAS) represent synthetic organic compounds extensively utilized in a variety of domestic and industrial products due to their distinctive characteristics. Designated as persistent organic pollutants (POPs) by the Stockholm Convention, PFAS are recognized for their long-lasting presence, widespread prevalence, and adverse impacts on both the environment and human health. Recently, the United States Environmental Protection Agency (US EPA) revised the guideline limits for perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in drinking water, setting them at 0.02 and 0.004 ng/L, respectively. Despite the global emphasis on the necessity for monitoring and treating PFAS in environmental media, there is a scarcity of information on PFAS studies in Africa. This gap may be attributed to a lack of modern laboratory facilities, weak governance, and the enforcement of environmental regulations. This study comprehensively reviews PFAS, focusing on key areas such as global guidelines and regulations, sources and distribution in the environmental matrix in Africa, characteristics, environmental fate, reported methods for sampling and analysis in Africa, and the role of government in the National Implementation Plan (NIP) on the continent. Additionally, the study offers recommendations and identifies knowledge gaps. In Africa, PFAS have been detected in various environmental compartments, including drinking water ranging from 0.03 to 200 ng/L, surface water ranging from 0.0254 to 788 ng/L, sediment ranging from 0.50 to 248.14 ng/g, wastewater ranging from 0.9 to 507 ± 257.6 ng/L, seafood ranging from 0.12 to 179.2 ng/g, sludge ranging from 0.01 to 0.098 ng/g, plants ranging from 0.160 to 29.33 ng/g, and indoor dust ranging from 1.3 to 69 ng/g. Notably, perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) are prevalent in samples from various environmental matrices across Africa. Reported sources of PFAS in African countries include municipal waste, hospital waste from medical equipment, discharge from industries, and wastewater treatment plants. Urgent attention is required from decision-makers and researchers in Africa to address PFAS monitoring, regulation, and treatment within the continent.
Graphical abstract
The Bergman spaces of generalized analytic functions on the upper half-plane
Authors: Qian Kanghui , Wang Hong , Li Zhongkai 
Published: October 2024

AbstractFor $$\lambda \ge 0$$

λ
≥
0

, a function f of $$z=x+iy$$

z
=
x
+
i
y

defined on a domain of the complex plane $${{\mathbb {C}}}$$
C
, symmetric about y-axis, is said to be $$\lambda $$
λ
-analytic if $$(D_x+i\partial _y)f=0$$

(

D
x

+
i

∂
y

)
f
=
0

, where $$D_x$$

D
x

is the Dunkl operator on the real line given by $$D_x\varphi (x)=\partial _x\varphi (x)+(\lambda /x)\left( \varphi (x)-\varphi (-x)\right) $$

D
x

φ

(
x
)

=

∂
x

φ

(
x
)

+

(
λ
/
x
)

φ
(
x
)
-
φ
(
-
x
)

. In the paper we study the Bergman space $$B_{\lambda }^p({{\mathbb {C}}}_+)$$

B

λ

p

(

C
+

)

associated with $$\lambda $$
λ
-analytic functions on the upper half-plane $${{\mathbb {C}}}_+$$

C
+

, and also its harmonic analog $$b_{\lambda }^p({{\mathbb {C}}}_+)$$

b

λ

p

(

C
+

)

. The reproducing kernels of $$B_{\lambda }^p({{\mathbb {C}}}_+)$$

B

λ

p

(

C
+

)

and $$b_{\lambda }^p({{\mathbb {C}}}_+)$$

b

λ

p

(

C
+

)

are determined and the reproducing formulas of functions in $$B_{\lambda }^p({{\mathbb {C}}}_+)$$

B

λ

p

(

C
+

)

and $$b_{\lambda }^p({{\mathbb {C}}}_+)$$

b

λ

p

(

C
+

)

are proved. The associated Bergman projections are proved to be bounded for $$1<p<\infty $$

1
<
p
<
∞

, and the completeness for $$1\le p<\infty $$

1
≤
p
<
∞

and the duality for $$1<p<\infty $$

1
<
p
<
∞

of $$B_{\lambda }^p({{\mathbb {C}}}_+)$$

B

λ

p

(

C
+

)

and $$b_{\lambda }^p({{\mathbb {C}}}_+)$$

b

λ

p

(

C
+

)

are also considered.
Targeting glucocorticoid receptor signaling pathway for treatment of stress-related brain disorders
Authors: Göver Tansu , Slezak Michal 
Published: October 2024

AbstractThe hypothalamic–pituitary–adrenal (HPA) axis plays a central role in governing stress-related disorders such as major depressive disorder (MDD), anxiety, and post-traumatic stress disorder. Chronic stress or early life trauma, known risk factors of disease, alter HPA axis activity and pattern of glucocorticoid (GC) secretion. These changes have consequences for physiological processes controlled by glucocorticoid receptor (GR) signaling, such as immune response and metabolism. In the brain, the aberrant GR signaling translates to altered behavior, making the GR pathway a viable target for therapies of stress-related disorders. One of the crucial elements of the pathway is FKBP5, a regulator of GR sensitivity and feedback control within the HPA axis, in which genetic variants were shown to moderate the risk of developing psychiatric conditions. The difficulty in targeting the GR-FKBP5 pathway stems from tailoring the intervention to specific brain regions and cell types, in the context of personalized genetic variations in GR and GR-associated genes, like FKBP5. The development of selective inhibitors, antagonists, and approaches based on targeted protein degradation offer insights into mechanistic aspects of disease and pave the way for improved therapy. These strategies can be employed either independently or in conjunction with conventional medications. Concomitant advancements in personalized drug screening (e.g. in vitro models exploiting induced pluripotent stem cells, iPSCs) bring the potential for optimization of therapy aiming to rescue central deficits originating from the HPA imbalance. In this mini-review, we discuss potential therapeutic strategies targeting GR signaling in stress-related disorders, with a focus on personalized approaches and advancements in drug development.
A national unmet needs assessment for CTSA-affiliated electronic health record data networks: A customer discovery approach
Authors: Mora Nallely , Mehall Madeline , Lennox Lindsay A. , Pincus Harold A. , Charron David , Morrato Elaine H. 
Published: October 2024

Abstract

Introduction:
The expansion of electronic health record (EHR) data networks over the last two decades has significantly improved the accessibility and processes around data sharing. However, there lies a gap in meeting the needs of Clinical and Translational Science Award (CTSA) hubs, particularly related to real-world data (RWD) and real-world evidence (RWE).

Methods:
We adopted a mixed-methods approach to construct a comprehensive needs assessment that included: (1) A Landscape Context analysis to understand the competitive environment; and (2) Customer Discovery to identify stakeholders and the value proposition related to EHR data networks. Methods included surveys, interviews, and a focus group.

Results:
Thirty-two CTSA institutions contributed data for analysis. Fifty-four interviews and one focus group were conducted. The synthesis of our findings pivots around five emergent themes: (1) CTSA segmentation needs vary according to resources; (2) Team science is key for success; (3) Quality of data generates trust in the network; (4) Capacity building is defined differently by researcher career stage and CTSA existing resources; and (5) Researchers’ unmet needs.

Conclusions:
Based on the results, EHR data networks like ENACT that would like to meet the expectations of academic research centers within the CTSA consortium need to consider filling the gaps identified by our study: foster team science, improve workforce capacity, achieve data governance trust and efficiency of operation, and aid Learning Health Systems with validating, applying, and scaling the evidence to support quality improvement and high-value care. These findings align with the NIH NCATS Strategic Plan for Data Science.
Ethnic Boundaries and Identity Fluidity of Bannermen and Civilians in the Qing Dynasty
Authors: Qiu Yuanyuan 
Published: October 2024

AbstractThe Qing dynasty enforced a policy of separate governance for the people of the Eight Banners, ruling that bannermen were neither to be administered under the regular civilian administrative system, nor listed on the civilian register. Institutionally and legally, the labels “Banner” (qi 旗) and “civilian” (min 民) marked a fundamental divide between different social groups in the Qing. However, in actual practice, the boundary between the two was less rigid. An ambiguous area existed within the seemingly strict legal and administrative regime, providing opportunists with an abundance of loopholes to exploit. Some changed their status from “civilian commoner” to “bannermen” to acquire land, while others moved from “bannermen” status to “civilian commoner” status to pursue promotion in the civil service. Shedding light on the everyday lives of these people, this article delves into the intricate Banner–civilian classification of the Qing dynasty, with a focus on the overlapping area between the parallel systems. It aims to rectify the conventional binary perspective that strictly dichotomizes Banner and civilian status. By doing so, it highlights the multifaceted nature and diversity inherent in Qing ethnic relations and local society.
A queue with independent and identically distributed arrivals
Authors: Mandjes Michel , Rutgers Daniël T. 
Published: October 2024

AbstractIn this paper we consider the workload of a storage system with the unconventional feature that the arrival times, rather than the interarrival times, are independent and identically distributed samples from a given distribution. We start by analyzing the ‘base model’ in which the arrival times are exponentially distributed, leading to a closed-form characterization of the queue’s workload at a given moment in time (i.e. in terms of Laplace–Stieltjes transforms), assuming the initial workload was 0. Then we consider four more general models, each of them having a specific additional feature: (a) the initial workload being allowed to have any arbitrary non-negative value, (b) an additional stream of Poisson arrivals, (c) phase-type arrival times, (d) balking customers. For all four variants the transform of the transient workload is identified in closed form.
Polarization versus professionalism: military and civilian views on the domestic use of the military
Authors: Hanson Kolby , Knuppe Austin J. 
Published: October 2024

Abstract
Scholars and policymakers warn that with rising affective polarization, politicians will find support from the public and permission from military professionals to use military force to selectively crack down on political opponents. We test these claims by conducting parallel survey experiments among the US public and mid-career military officers. We ask about two hypothetical scenarios of domestic partisan unrest, randomly assigning the partisan identity of protesters. Surprisingly, we find widespread public support for deploying the military and no significant partisanship effects. Meanwhile, military officers were very resistant to deploying the military, with nearly 75 percent opposed in any scenario. In short, there is little evidence that public polarization threatens to escalate domestic disputes, and strong evidence for military opposition.
TRANS PARENTHOOD IN THE UK: THE “UNANSWERED QUESTIONS” OF THE MCCONNELL LITIGATION
Authors: Dunne Peter , Brown Alan 
Published: October 2024

AbstractThis article considers three “unanswered questions” raised by R. (McConnell) v Registrar General for England and Wales (AIRE Centre Intervening) [2020] EWCA Civ. 559, which held that a trans man (with a Gender Recognition Certificate) who gave birth must be registered as “mother” on his child’s birth certificate. This article considers these questions to clearly situate McConnell within the context of the UK’s legal regimes concerning access to fertility treatment, gender recognition and legal parenthood in cases involving assisted reproduction. The article argues that clearly establishing the current legal position will provide the proper context to facilitate any subsequent legal reforms.
Yangzhou, 1342: Caterina Vilioni's Passport to the Afterlife
Authors: Ilko Krisztina 
Published: October 2024

AbstractThe tombstone of an Italian woman, Caterina Vilioni, in Yangzhou (1342) is a rare and important testimony to Christianity in Yuan China. By exploring the visual language and the multicultural geopolitical context of Caterina's funerary monument, this article sheds light on the dynamic processes behind how cultural and religious barriers were negotiated in the premodern Eurasian world. Despite the increasing scholarly interest in the European import of Asian luxury merchandise along the Silk Roads, movement of objects, persons, and ideas the other way around from Europe to Asia is much less explored. Moreover, the expansion of European networks towards the east was written from the perspective of men: friars, diplomats and merchants. Yet, the Yangzhou tombstone directs attention to the overlooked presence of non-elite Christian women in the cosmopolitan port cities of south-east China well before the era of modern global maritime exchange. While previous scholars traced the tombstone to Buddhist and Christian art, I argue that the visual language intentionally projected cultural ambiguity. By comparing it to the Mongol paiza (safe conduct pass), this article proposes that Caterina's burial marker functioned as an ‘otherworldly passport’, which invoked spiritual protection and facilitated the passage between two realms.
Preferential use of full glottal stops in vowel-initial glottalization in child speech: Evidence from novel words
Authors: Repiso-Puigdelliura Gemma 
Published: October 2024

Abstract
Vowel-initial glottalization constitutes a cue to prosodic prominence, realized on a strength continuum from creaky phonation to complete glottal stops. While there is considerable research on children’s early utilization of acoustic cues for stress marking, less is understood about the specific implementation of vowel-initial glottalization in American English. Eight sequences of function + novel words were elicited from groups of 5-to-8-year-olds, 8-to-11-year-olds, and adults. Children exhibit a similar rate of prevocalic glottalization to adults but differ in its phonetic implementation, producing a higher rate of glottal stops compared to creaky phonation with respect to adults.
Two hundred and twenty-nine cases of bidirectional cavopulmonary anastomosis with and without antegrade pulmonary blood flow, a single-center experience
Authors: Delikatnyi Maksym , Sekelyk Roman , Maksymenko Andrii , Kurkevych Andrii 
Published: October 2024

AbstractBidirectional cavopulmonary anastomosis is palliative surgical procedure for stepwise adaptation of the ventricle by time-phased relief of blood volume from the single functional ventricle. There still exists a controversial question regarding maintaining additional antegrade pulmonary blood flow. We retrospectively reviewed the surgical cases of 261 patients who underwent bidirectional cavopulmonary anastomosis in our institution from 2012 to 2022 with special regard to antegrade pulmonary blood flow as our preferred strategy. The mean age at the time of surgery was 33.1 months (range 2.9–192 months), and the mean weight was – 7.6 kg (range 3.9–38 kg). Furthermore, we divided all the patients into two groups: in group 1 (n = 182) – patients who underwent bidirectional cavopulmonary anastomosis with antegrade pulmonary blood flow, and in group 2 (n = 47) – patients without antegrade pulmonary blood flow. The mean follow-up time was 56 months (range 24–120 months). Mortality rate was 4.8 % (n = 11) in the past 10 years. Statistical difference between groups was in the following positions: group 2 had less ICU stay (p < 0.000125) and hospital stay (p < 0.017110); group 1 had a longer duration of pleural effusion (p < 0.000003) and amount of drainage output (p < 0.007), also demonstrated higher oxygen saturation (p < 0.000264) and Glenn shunt pressure (p < 0.002) after the surgery; but there was no difference in oxygen saturation after 6, 12, and 24 months; mortality in both groups has no statistic difference. Considering our experience, we take a stand on the controlled to antegrade pulmonary blood flow strategy during bidirectional cavopulmonary anastomosis.
Incidence, pathophysiology, and treatment of failing Fontan after the total cavopulmonary connection
Authors: Gaebert Paula , Schaeffer Thibault , Palm Jonas , Di Padua Chiara , Niedermaier Carolin , Piber Nicole , Hager Alfred , Ewert Peter , Hörer Jürgen , Ono Masamichi 
Published: October 2024

AbstractBackground:Failing Fontan poses a significant clinical challenge. This study aims to improve patients’ outcomes by comprehensively understanding the incidence, pathophysiology, risk factors, and treatment of failing Fontan after total cavopulmonary connection.Methods:We performed a retrospective analysis of patients who underwent total cavopulmonary connection at the German Heart Center Munich between 1994 and 2022. The onset of failing Fontan was defined as: protein-losing enteropathy, plastic bronchitis, NYHA class IV, NYHA class III for > one year, unscheduled hospital admissions for heart failure symptoms, and evaluation for heart transplantation.Results:Among 634 patients, 76 patients presented with failing Fontan, and the incidence was 1.48 per 100 patient-years. Manifestations included protein-losing enteropathy (n = 34), hospital readmission (n = 28), NYHA III (n = 18), plastic bronchitis (n = 16), evaluation for heart transplantation (n = 14), and NYHA IV (n = 4). Risk factors for the onset of failing Fontan were dominant right ventricle (p = 0.010) and higher pulmonary artery pressure before total cavopulmonary connection (p = 0.004). A total of 72 interventions were performed in 59 patients, including balloon dilatation/stent implantation in the total cavopulmonary connection pathway (n = 49) and embolization of collaterals (n = 24). Heart transplantation was performed in four patients. The survival after the onset of Fontan failure was 77% at 10 years. Patients with failing Fontan revealed significantly higher zlog-NT-proBNP levels after onset compared to those without (p = 0.021)Conclusions:The incidence of Fontan failure was 1.5 per 100 patient years. Dominant right ventricle and higher pulmonary artery pressure before total cavopulmonary connection were significant risks for the onset of failing Fontan. Zlog-NT-proBNP is only a late marker of Fontan failure.
What is pentalogy of Cantrell?
Authors: Mejías Exa M. , Carrión Enrique , Sparman Arnelle , Juliana Amadu 
Published: October 2024

AbstractWe present the unusual case of an 8-month-old female with tetralogy of Fallot, coarctation of aorta, and complete presentation of pentalogy of Cantrell. A meta-analysis of 236 cases of Cantrell’s syndrome reported in the literature was performed to compare intracardiac findings.
Complete atrioventricular block after atrial flow regulator implantation in a 5 kg infant
Authors: Grunenwald Gronier Céline , Benbrik Nadir , Baruteau Alban-Elouen 
Published: October 2024

AbstractThe atrial flow regulator is a new self-expandable double-disc fenestrated device providing a calibrated inter-atrial communication. Paediatric reports are scarce. We herein describe a case of complete atrioventricular block complicating the exemption use of an atrial flow regulator in a 5-kg infant with transposition of the great arteries, ventricular septal defect, and right ventricular outflow tract obstruction.
The novel and slowest arterial pressure waves: clinical implications in children with congenital heart disease following cardiovascular surgery
Authors: Ma Li , Yu Linyang , Liu Yingying , Lin Rouyi , Feng Jinqing , Cui Yanqin , Li Jianbin , Li Lijuan , Ning Shuyao , Zou Minghui , Huang Guodong , Wang Huaizhen , Chen Xinxin , Li Jia 
Published: October 2024

AbstractObjectives:Certain rhythmic arterial pressure waves in humans and animals have been noticed for over one century. We found the novel and slowest arterial pressure waves in children following surgical repair for CHD, and examined their characteristics and clinical implications.Methods:We enrolled 212 children with 22 types of CHD within postoperative 48 h. We monitored haemodynamics (blood pressure, cardiac cycle efficiency, dP/dTmax), cerebral (ScO2), and renal (SrO2) oxygen saturation every 6 s. Electroencephalogram was continuously monitored. Mean blood flow velocity (Vm) of the middle cerebral artery was measured at 24 h.Results:We found the waves with a frequency of ∼ 90 s immediately following surgical repair in 46 patients in 12 types of CHD (21.7%), being most prevalent in patients with aortic arch abnormalities (Aorta Group, n = 24, 42.3%) or ventricular septal defect (Ventricular Septal Defect Group, n = 12, 23.5%). In Aorta and Ventricular Septal Defect Groups, the occurrence of the waves was associated with lower blood pressures, dP/dTmax, cardiac cycle efficiency, ScO2, SrO2, Vm, worse electroencephalogram background abnormalities, higher number of electroencephalogram sharp waves, and serum lactate (Ps <0.0001–0.07), and were accompanied with fluctuations of ScO2 and SrO2 in 80.6% and 69.6% of patients, respectively.Conclusions:The waves observed in children following cardiovascular surgery are the slowest ever reported, occurring most frequently in patients with aortic arch abnormalities or ventricular septal defect. While the occurrence of the waves was associated with statistically worse and fluctuated ScO2 and SrO2, worse systemic haemodynamics, and electroencephalogram abnormalities, at present these waves have no known clinical relevance.