bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonatheroscleotic Isolated Middle Cerebral Artery Disease May Be Early Manifestation of Moyamoya Disease
Authors: Kim Yeon-Jung , Lee Joo Kyung , Ahn Sung-Ho , Kim Bum Joon , Kang Dong-Wha , Kim Jong S. , Kwon Sun U. 
Published: August 2016

Background and Purpose—

Middle cerebral artery steno-occlusive disease (MCAD) is not an uncommon cause of ischemic stroke in young Asians. Aside from atherosclerosis, the pathogenesis of MCAD include various nonatherosclerotic vasculopathies, most of which are yet to be defined. This study investigated the pathogenesis of symptomatic isolated MCAD in young Asian patients using high-resolution magnetic resonance imaging (HR-MRI) and mutation analysis of
RNF213
.

Methods—
Patients aged <60 years with stroke or transient ischemic attack caused by MCAD were prospectively enrolled. Patients with a confirmed diagnosis of moyamoya disease, dissection, and vasculitis; with significant steno-occlusion in cerebral arteries other than the MCA; or with high-risk cardioembolic source were excluded. Using high-resolution MRI, patients were classified into an atherosclerosis group and a nonatherosclerosis group.

Results—

Eighty-one patients were enrolled, 45 (56.6%) in the atherosclerosis and 36 (44.4%) in the nonatherosclerosis group. The nonatherosclerosis group was significantly younger (
P
=0.013), had a smaller number of vascular risk factors (
P
=0.001), showed a lower homocysteine level (
P
<0.001), thinner intima-media thickness (
P
=0.006), and had more frequent heterozygotes at
RNF213
(
P
=0.045) than the atherosclerosis group. Diffusion-weighted image lesion pattern showed no significant differences in assumed stroke mechanisms between the 2 groups.

Conclusions—

Nonatherosclerotic pathogenesis are common in young Asians with symptomatic isolated MCAD. Clinical findings, high-resolution MRI features, and results of
RNF213
mutation analysis suggest that moyamoya disease is responsible etiologically for a significant portion of nonatherosclerotic lesions. Symptomatic isolated MCAD may be an early manifestation of moyamoya disease in young Asian adults.
Affective Prosody and Depression After Stroke
Authors: Villain Marie , Cosin Charlotte , Glize Bertrand , Berthoz Sylvie , Swendsen Joel , Sibon Igor , Mayo Willy 
Published: August 2016

Background and Purpose—
Poststroke depression (PSD) is a frequent complication of stroke with detrimental consequences in terms of quality of life and functional outcomes. In individuals with major depression, several studies have demonstrated an alteration of affective prosody. The aim of this study is to identify prosodic markers that may be predictive of PSD.

Methods—
Patient voices were recorded at baseline and 3 months after stroke. We extracted prosodic parameters, including fundamental frequency, percentage of voice breaks, and shimmer. Depression and anxiety symptoms were assessed 3 months later.

Results—
Among the 49 patients included in the study, 22.5% developed PSD 3 months after stroke. A significant decrease was observed concerning the fundamental frequency among patients who developed PSD. Discriminant analysis demonstrated that initial voice breaks coupled with shimmer are strongly predictive of subsequent PSD.

Conclusions—
Early alterations of affective prosody are associated with a higher risk of PSD 3 months after a stroke. This new physiological approach overcomes traditional barriers associated with clinical instruments and contributes to the prediction of this disorder.
Automated CT Perfusion Ischemic Core Volume and Noncontrast CT ASPECTS (Alberta Stroke Program Early CT Score)
Authors: Haussen Diogo C. , Dehkharghani Seena , Rangaraju Srikant , Rebello Leticia C. , Bouslama Mehdi , Grossberg Jonathan A. , Anderson Aaron , Belagaje Samir , Frankel Michael , Nogueira Raul G. 
Published: August 2016

Background and Purpose—
The semiquantitative noncontrast CT Alberta Stroke Program Early CT Score (ASPECTS) and RAPID automated computed tomography (CT) perfusion (CTP) ischemic core volumetric measurements have been used to quantify infarct extent. We aim to determine the correlation between ASPECTS and CTP ischemic core, evaluate the variability of core volumes within ASPECTS strata, and assess the strength of their association with clinical outcomes.

Methods—
Review of a prospective, single-center database of consecutive thrombectomies of middle cerebral or intracranial internal carotid artery occlusions with pretreatment CTP between September 2010 and September 2015. CTP was processed with RAPID software to identify ischemic core (relative cerebral blood flow<30% of normal tissue).

Results—

Three hundred and thirty-two patients fulfilled inclusion criteria. Median age was 66 years (55–75), median ASPECTS was 8 (7–9), whereas median CTP ischemic core was 11 cc (2–27). Median time from last normal to groin puncture was 5.8 hours (3.9–8.8), and 90-day modified Rankin scale score 0 to 2 was observed in 54%. The correlation between CTP ischemic core and ASPECTS was fair (
R
=−0.36;
P
<0.01). Twenty-six patients (8%) had ASPECTS <6 and CTP core ≤50 cc (37% had modified Rankin scale score 0–2, whereas 29% were deceased at 90 days). Conversely, 27 patients (8%) had CTP core >50 cc and ASPECTS ≥6 (29% had modified Rankin scale 0–2, whereas 21% were deceased at 90 days). Moderate correlations between ASPECTS and final infarct volume (
R
=−0.42;
P
<0.01) and between CTP ischemic core and final infarct volume (
R
=0.50;
P
<0.01) were observed; coefficients were not significantly influenced by the time from stroke onset to presentation. Multivariable regression indicated ASPECTS ≥6 (odds ratio 4.10; 95% confidence interval, 1.47–11.46;
P
=0.01) and CTP core ≤50 cc (odds ratio 3.86; 95% confidence interval, 1.22–12.15;
P
=0.02) independently and comparably predictive of good outcome.

Conclusions—
There is wide variability of CTP-derived core volumes within ASPECTS strata. Patient selection may be affected by the imaging selection method.
Does Admission to Hospital Affect Trends in Survival and Dependency After Stroke Using the South London Stroke Register?
Authors: Bhalla Ajay , Wang Yanzhong , Rudd Anthony , Wolfe Charles D.A. 
Published: August 2016

Background and Purpose—
Despite guidelines for specialist assessment in hospital for stroke, it is important to identify patient characteristics, trends, and outcome in patients not admitted to hospital compared with patients admitted to hospital.

Methods—
Population-based stroke register of first in a life time strokes between 1995 and 2012 were examined. Baseline data included admission or nonadmission, case mix, stroke subtype, and risk factors before stroke. Survival curves were estimated with Kaplan–Meier methods. Logistic regression was used to determine factors associated with poor outcome (dead and dependency: Barthel index, <15) at 3 months and 1 year.

Results—

Three thousand four hundred sixty-four patients were admitted to hospital for stroke. Patients admitted were more likely have more severe impairments (
P
<0.001). There was a significant trend for increasing admission over time; 1995 to 2000 (82%), 2001 to 2006 (90%), and 2007 to 2012 (94%);
P
<0.001. When survival analysis was stratified according to Barthel index ≥15 at day 7, there were no significant differences in survival curves between admission and nonadmission groups in 1995 to 2000 (
P
=0.15) or 2001 to 2006 (
P
=0.06), but there was a significant trend for higher survival rates for nonadmission in the 2007 to 2012 cohort (
P
=0.025). Admission to hospital (stroke unit) compared with nonadmission was also associated with poor outcome in the 2001 to 2006 time period (odds ratio, 2.66; confidence interval, 1.17–6.04) and the 2007 to 2012 time period (odds ratio, 5.26; confidence interval, 1.27–21.81).

Conclusion—
There is a survival advantage from 2007 onward and lower levels of dependency from 2001 onward after adjusting for case mix for those patients who are not admitted to hospital, which requires further explanation.
The Sensitivity of WRF Downscaled Precipitation in Puerto Rico to Cumulus Parameterization and Interior Grid Nudging
Authors: Wootten A. , Bowden J. H. , Boyles R. , Terando A. 
Published: August 2016

AbstractThe sensitivity of the precipitation over Puerto Rico that is simulated by the Weather Research and Forecasting (WRF) Model is evaluated using multiple combinations of cumulus parameterization (CP) schemes and interior grid nudging. The NCEP–DOE AMIP-II reanalysis (R-2) is downscaled to 2-km horizontal grid spacing both with convective-permitting simulations (CP active only in the middle and outer domains) and with CP schemes active in all domains. The results generally show lower simulated precipitation amounts than are observed, regardless of WRF configuration, but activating the CP schemes in the inner domain improves the annual cycle, intensity, and placement of rainfall relative to the convective-permitting simulations. Furthermore, the use of interior-grid-nudging techniques in the outer domains improves the placement and intensity of rainfall in the inner domain. Incorporating a CP scheme at convective-permitting scales (<4 km) and grid nudging at non-convective-permitting scales (>4 km) improves the island average correlation of precipitation by 0.05–0.2 and reduces the island average RMSE by up to 40 mm on average over relying on the explicit microphysics at convective-permitting scales with grid nudging. Projected changes in summer precipitation between 2040–42 and 1985–87 using WRF to downscale CCSM4 range from a 2.6-mm average increase to an 81.9-mm average decrease, depending on the choice of CP scheme. The differences are only associated with differences between WRF configurations, which indicates the importance of CP scheme for projected precipitation change as well as historical accuracy.
An Investigation of the Presence of Atmospheric Rivers over the North Pacific during Planetary-Scale Wave Life Cycles and Their Role in Arctic Warming
Authors: Baggett Cory , Lee Sukyoung , Feldstein Steven 
Published: August 2016

AbstractHeretofore, the tropically excited Arctic warming (TEAM) mechanism put forward that localized tropical convection amplifies planetary-scale waves, which transport sensible and latent heat into the Arctic, leading to an enhancement of downward infrared radiation and Arctic surface warming. In this study, an investigation is made into the previously unexplored contribution of the synoptic-scale waves and their attendant atmospheric rivers to the TEAM mechanism. Reanalysis data are used to conduct a suite of observational analyses, trajectory calculations, and idealized model simulations. It is shown that localized tropical convection over the Maritime Continent precedes the peak of the planetary-scale wave life cycle by ~10–14 days. The Rossby wave source induced by the tropical convection excites a Rossby wave train over the North Pacific that amplifies the climatological December–March stationary waves. These amplified planetary-scale waves are baroclinic and transport sensible and latent heat poleward. During the planetary-scale wave life cycle, synoptic-scale waves are diverted northward over the central North Pacific. The warm conveyor belts associated with the synoptic-scale waves channel moisture from the subtropics into atmospheric rivers that ascend as they move poleward and penetrate into the Arctic near the Bering Strait. At this time, the synoptic-scale waves undergo cyclonic Rossby wave breaking, which further amplifies the planetary-scale waves. The planetary-scale wave life cycle ceases as ridging over Alaska retrogrades westward. The ridging blocks additional moisture transport into the Arctic. However, sensible and latent heat amounts remain elevated over the Arctic, which enhances downward infrared radiation and maintains warm surface temperatures.
Understanding Rapid Changes in Phase Partitioning between Cloud Liquid and Ice in Stratiform Mixed-Phase Clouds: An Arctic Case Study
Authors: Kalesse Heike , de Boer Gijs , Solomon Amy , Oue Mariko , Ahlgrimm Maike , Zhang Damao , Shupe Matthew D. , Luke Edward , Protat Alain 
Published: August 2016

AbstractUnderstanding phase transitions in mixed-phase clouds is of great importance because the hydrometeor phase controls the lifetime and radiative effects of clouds. In high latitudes, these cloud radiative effects have a crucial impact on the surface energy budget and thus on the evolution of the ice cover. For a springtime low-level mixed-phase stratiform cloud case from Barrow, Alaska, a unique combination of instruments and retrieval methods is combined with multiple modeling perspectives to determine key processes that control cloud phase partitioning. The interplay of local cloud-scale versus large-scale processes is considered. Rapid changes in phase partitioning were found to be caused by several main factors. Major influences were the large-scale advection of different air masses with different aerosol concentrations and humidity content, cloud-scale processes such as a change in the thermodynamical coupling state, and local-scale dynamics influencing the residence time of ice particles. Other factors such as radiative shielding by a cirrus and the influence of the solar cycle were found to only play a minor role for the specific case study (11–12 March 2013). For an even better understanding of cloud phase transitions, observations of key aerosol parameters such as profiles of cloud condensation nucleus and ice nucleus concentration are desirable.
Atmosfear: Communicating the Effects of Climate Change on Extreme Weather
Authors: Janković Vladimir , Schultz David M. 
Published: August 2016

Abstract
The potential and serious effects of anthropogenic climate change are often communicated through the soundbite that anthropogenic climate change will produce more extreme weather. This soundbite has become popular with scientists and the media to get the public and governments to act against further increases in global temperature and their associated effects through the communication of scary scenarios, what the authors term “atmosfear.” Underlying atmosfear’s appeal, however, are four premises. First, atmosfear reduces the complexity of climate change to an identifiable target in the form of anthropogenically forced weather extremes. Second, anthropogenically driven weather extremes mandate a responsibility to act to protect the planet and society from harmful and increased risk. Third, achieving these ethical goals is predicated on emissions policies. Fourth, the end result of these policies—a nonanthropogenic climate—is assumed to be more benign than an anthropogenically influenced one. Atmosfear oversimplifies and misstates the true state of the science and policy concerns in three ways. First, weather extremes are only one of the predicted effects of climate change and are best addressed by measures other than emission policies. Second, a preindustrial climate may remain a policy goal, but it is unachievable in reality. Third, the damages caused by any anthropogenically driven extremes may be overshadowed by the damages caused by increased exposure and vulnerability to the future risk. In reality, recent increases in damages and losses due to extreme weather events are due to societal factors. Thus, invoking atmosfear through such approaches as attribution science is not an effective means of either stimulating or legitimizing climate policies.
Trajectories of major depression disorders: A systematic review of longitudinal neuroimaging findings
Authors: Dohm Katharina , Redlich Ronny , Zwitserlood Pienie , Dannlowski Udo 
Published: August 2016

Objective: Structural and functional brain alterations in major depression disorder (MDD) are well studied in cross-sectional designs, but little is known about the causality between onset and course of depression on the one hand, and neurobiological changes over time on the other. To explore the direction of causality, longitudinal studies with a long time window (preferably years) are needed, but only few have been undertaken so far. This article reviews all prospective neuroimaging studies in MDD patients currently available and provides a critical discussion of methodological challenges involved in the investigation of the causal relationship between brain alterations and the course of MDD. Method: We conducted a systematic review of studies published before September 2015, to identify structural magnetic resonance imaging (MRI) studies that assess the relation between neuronal alterations and MDD in longitudinal (⩾1 year) designs. Results: Only 15 studies meeting minimal standards were identified. An analysis of these longitudinal data showed a large heterogeneity between studies regarding design, samples, imaging methods, spatial restrictions and, consequently, results. There was a strong relationship between brain-volume outcomes and the current mood state, whereas longitudinal studies failed to clarify the influence of pre-existing brain changes on depressive outcome. Conclusion: So far, available longitudinal studies cannot resolve the causality between the course of depression and neurobiological changes over time. Future studies should combine high methodological standards with large sample sizes. Cooperation in multi-center studies is indispensable to attain sufficient sample sizes, and should allow careful assessment of possible confounders.
Direct and Indirect Experiential Effects in an Updating Model of Deterrence
Authors: Wilson Theodore , Paternoster Ray , Loughran Thomas 
Published: August 2016

Objectives: Sanction risk perceptions are a central element of deterrence theory, but the process by which an offender’s direct and indirect criminal experiences contribute to future risk perceptions has been understudied. This note seeks to address this domain through an extension of updating model of Anwar and Loughran to account for two distinct information signals obtained by an offender through (1) their personal criminal experiences and (2) the criminal experiences of their family members. Further, this model is extended to assess for any differential updating according to the presence of low impulse control. Methods: Data for this analysis were obtained from the Pathways to Desistance study. Random effects models were employed to model the updating process directly. Results: Having criminal family members who did not get arrested during the current period had the most criminogenic effect upon one’s personal perception of sanction risk, but simply having family members commit crime, regardless of sanction status, appears to be criminogenic. Those with low impulse control place greater weight upon their personal information than vicarious information obtained from their family members. Conclusions: These findings offer some insight into a mechanism that may underlay the delinquent peer effect and warrants future inquiry.
Risperidone increases the cortical silent period in drug-naive patients with first-episode schizophrenia: A transcranial magnetic stimulation study
Authors: Ustohal Libor , Mayerova Michaela , Hublova Veronika , Prikrylova Kucerova Hana , Ceskova Eva , Kasparek Tomas 
Published: August 2016

Objectives: Schizophrenia is accompanied by impaired cortical inhibition, as measured by several markers including the cortical silent period (CSP). It is thought that CSP measures gamma-aminobutyric acid receptors B (GABAB) mediated inhibitory activity. But the mutual roles of schizophrenia as a disease and the drugs used for the treatment of psychosis on GABA mediated neurotransmission are not clear. Methods: We recruited 13 drug-naive patients with first-episode schizophrenia. We used transcranial magnetic stimulation to assess CSP prior to initiating risperidone monotherapy and again four weeks later. At the same time, we rated the severity of psychopathology using the Positive and Negative Syndrome Scale (PANSS). Results: We obtained data from 12 patients who showed a significant increase in CSP, from 134.20±41.81 ms to 162.95±61.98 ms ( p=0.041; Cohen’s d=0.544). After the treatment, the PANSS total score was significantly lower, as were the individual subscores ( p<0.05). However, no correlation was found between ΔCSP and ΔPANSS. Conclusion: Our study in patients with first-episode schizophrenia demonstrated an association between risperidone monotherapy and an increase in GABAB mediated inhibitory neurotransmission.
Long-term Functional and Radiographic Outcome of a Mobile Bearing Ankle Prosthesis
Authors: Kerkhoff Yvonne R. A. , Kosse Nienke M. , Metsaars Wieneke P. , Louwerens Jan Willem K. 
Published: August 2016

Background: Total ankle arthroplasty is an accepted alternative to arthrodesis of the ankle. However, complication and failure rates remain high. Long-term results of the Scandinavian Total Ankle Replacement (STAR) are limited, with variable complication and failure rates observed. This prospective study presents the long-term survivorship and postoperative complications of the STAR prosthesis. Methods: Between May 1999 and June 2008, 134 primary total ankle arthroplasties were performed using the STAR prosthesis in 124 patients. The survivorship, postoperative complications, and reoperations were recorded, with a minimum follow-up period of 7.5 years. Clinical results were assessed using the Foot Function Index and the Kofoed score. The presence of component migration, cysts, and radiolucency surrounding the prosthesis components, heterotopic ossification, and progression of osteoarthritis in adjacent joints were determined. Results: The cumulative survival was 78% after the 10-year follow-up period. An ankle arthrodesis was performed in 20 ankles (14.9%) that failed. Fourteen polyethylene insert fractures occurred (10.4%). Other complications occurred in 29 ankles (21.6%), requiring secondary procedures in 21 ankles (15.7%). Nevertheless, the postoperative clinical results improved significantly. Osteolytic cysts were observed in 61 ankles (59.8%) and the surface area of these cysts increased during follow-up, without any association with the prosthesis alignment or clinical outcome. Heterotopic ossification at the medial malleolus was present in 58 cases (56.8%) and at the posterior tibia in 73 cases (71.6%), with no effect on clinical outcome. Osteoarthritis of the subtalar and talonavicular joint developed in 9 (8.8%) and 11 cases (10.8%), respectively. Conclusion: The long-term clinical outcomes for the STAR were found to be satisfactory. Although these results are consistent with previous studies, the survival and complication rates are disappointing compared to knee and hip arthroplasty. Higher rates of successful outcomes following ankle arthroplasty are important, and these results highlight the need for further research to clarify the origin and significance of the reported complications. Level of Evidence: Level II, prospective comparative study.