bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peripheral provocation of cranial autonomic symptoms is not sufficient to trigger cluster headache attacks
Authors: Möller Maike , Haji Ame Abdu , Hoffmann Jan , May Arne 
Published: October 2017

Background Recently it has been suggested that low frequency stimulation of the sphenopalatine ganglion (SPG) may provoke cluster-like attacks in cluster headache (CH) patients. The question arises whether a robust activation of cranial autonomic symptoms is sufficient to trigger CH attacks. Methods Kinetic oscillation stimulation (KOS) of the nasal mucosa generates ipsilateral marked autonomic symptoms, among which lacrimation is quantitatively measurable. KOS was applied to 29 CH-patients, including both episodic and chronic course. We measured lacrimation at rest and during stimulation, and assessed CH attacks within 24 hours after the experiment. Results Autonomic symptoms including lacrimation were robust and significantly generated, compared to rest. Six patients were lost to follow-up, but did not develop an attack during their stay in the clinic. Of the remaining 23 patients, none developed an attack in the next 4 hours after stimulation, despite marked cranial autonomic symptoms during stimulation. Discussion Peripheral stimulation close to the SPG generated a strong parasympathetic response. However, this stimulation was not sufficient to induce CH attacks, which suggests that a central component is crucial to attack generation.
Migraine with brainstem aura: Why not a cortical origin?
Authors: Demarquay Geneviève , Ducros Anne , Montavont Alexandra , Mauguiere François 
Published: October 2017

Background Migraine with brainstem aura is defined as a migraine with aura including at least two of the following symptoms: dysarthria, vertigo, tinnitus, hypacusis, diplopia, ataxia and/or decreased level of consciousness. Aim The aim of this study is to review data coming from clinical observations and functional mapping that support the role of the cerebral cortex in the initiation of brainstem aura symptoms. Results Vertigo can result from a vestibular cortex dysfunction, while tinnitus and hypacusis can originate within the auditory cortex. Diplopia can reflect a parieto-occipital involvement. Dysarthria can be caused by dysfunctions located in precentral gyri. Ataxia can reflect abnormal processing of vestibular, sensory, or visual inputs by the parietal lobe. Alteration of consciousness can be caused by abnormal neural activation within specific consciousness networks that include prefrontal and posterior parietal cortices. Conclusion Any symptom of so-called brainstem aura can originate within the cortex. Based on these data, we suggest that brainstem aura could have a cortical origin. This hypothesis would explain the co-occurrence of typical and brainstem aura during attacks and would fit with the theory of cortical spreading depression. We propose that migraine with brainstem aura should be classified as a typical migraine aura.
Maternal Mental Health after Custody Loss and Death of a Child: A Retrospective Cohort Study Using Linkable Administrative Data
Authors: Wall-Wieler Elizabeth , Roos Leslie L. , Bolton James , Brownell Marni , Nickel Nathan , Chateau Dan 
Published: October 2017

Objective: The objective was to compare mental illness diagnoses and treatment use among mothers who lost custody of their child through involvement with child protection services and those seen in mothers dealing with the death of a child. Methods: We studied mental health outcomes of a cohort of women whose first child was born in Manitoba, Canada between 1 April 1997 and 31 March 2015. Of these women, 5,792 had a child taken into care, and 1,143 mothers experienced the death of a child (<18 y old) before 31 March 2015. Adjusted relative rates (ARR) of 3 mental health diagnoses and 3 mental health treatment use outcomes between these 2 groups were examined. Results: Mothers with a child taken into care had significantly greater ARR of depression (ARR = 1.90; 95% CI, 1.82 to 1.98), anxiety (ARR = 2.51; 95% CI, 2.40 to 2.63), substance use (ARR = 8.54; 95% CI, 7.49 to 9.74), physician visits for mental illness (ARR = 3.01; 95% CI, 2.91 to 3.12), and psychotropic medication use (ARR = 4.95; 95% CI, 4.85 to 5.06) in the years after custody loss compared with mothers who experienced the death of a child. Conclusion: Losing custody of a child to child protection services is associated with significantly worse maternal mental health than experiencing the death of a child. Greater acknowledgement and supportive services should be provided to mothers experiencing the loss of a child through the involvement of child protection services.
Urinary neutrophil gelatinase-associated lipocalin and monocyte chemoattractant protein 1 as biomarkers for lupus nephritis in Colombian SLE patients
Authors: Gómez-Puerta J A , Ortiz-Reyes B , Urrego T , Vanegas-García A L , Muñoz C H , González L A , Cervera R , Vásquez G 
Published: October 2017

Background Information regarding urinary biomarkers in Mestizo and Afro-Latin-American patients is very limited. We investigated whether levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), and monocyte chemoattractant protein 1 (MCP-1) are good biomarkers to differentiate patients with lupus nephritis among Latin-American systemic lupus erythematosus (SLE) patients. Methods SLE patients meeting the revised American College of Rheumatology classification criteria for SLE were recruited. Urinary levels of NGAL and MCP-1 were measured using a commercial ELISA kit. Serum anti-C1q antibodies were measured by ELISA. SLE activity was measured with the systemic lupus erythematosus disease activity index (SLEDAI). Mann–Whitney tests were used to compare data and Spearman’s rank correlations were used to examine associations between continuous variables. In addition, receiver operating characteristic curves were performed. Results One hundred and twenty SLE patients were recruited (87% women) with a median age of 32.8 ± 12.1 years and median disease duration of 7.3 ± 6.9 years. Afro-Latin-Americans had a significantly higher prevalence of lupus nephritis and higher SLEDAI scores than Mestizos. The three biomarkers were significantly higher in patients with lupus nephritis than in patients without lupus nephritis. In addition, urinary NGAL and MCP-1 were significantly higher in patients with active lupus nephritis than in inactive lupus nephritis. Urinary NGAL levels were significantly higher in Afro-Latin-American patients. A receiver operating characteristic curve for urinary biomarkers for lupus nephritis in all SLE patients showed a good level of sensitivity and specificity. Conclusion In our cohort of SLE patients, we found that urinary NGAL and MCP-1 in addition to anti-C1q antibodies were useful biomarkers for the identification of renal involvement and discrimination of active lupus nephritis among patients with renal disease.
Case formulation using Pattern-based Formulation (PBF) methodology: clinical case 2
Authors: Fernando Irosh , Rajasooriya Mahesh 
Published: October 2017

Objectives: To teach psychiatric case formulation; to build a repertoire of patterns that can be reused as building blocks in constructing case formulations. Method: Pattern-based Formulation. Results: Demonstration of a case formulation and introducing three patterns. Conclusion: The demonstration will assist learning case formulation using the Pattern-based Formulation, while the three patterns introduced can be reused when formulating relevant cases.
Distance Between the Anterior Distal Tibial Edge and the Anterior Tibial Artery in Distraction and Nondistraction During Anterior Ankle Arthroscopy: A Cadaveric Study
Authors: Tonogai Ichiro , Hayashi Fumio , Tsuruo Yoshihiro , Sairyo Koichi 
Published: October 2017

Background: Anterior ankle arthroscopy is widely applied for various osteoarthropathies. However, distraction of the ankle may put the anterior tibial artery (ATA) at risk of injury during the procedure. The purpose of this study was to assess the difference in the distance between the anterior distal tibial edge and the ATA in distraction and nondistraction of the ankle with joint space expansion by saline injection into the joint. Methods: Eight whole fresh-frozen cadaveric feet (mean age 78.9 years) were used. Barium sulfate suspension was injected into the popliteal artery of each specimen, and the distance from 3 aspects of the anterior distal tibial edge to the ATA was measured to evaluate the possibility of damage to the ATA based on computed tomography (CT) scans, in ankle distraction and nondistraction, using a traction device developed for reproducible ankle positioning inside the CT scanner. Results: The distance between the ATA and the most proximal, middle, and distal parts of the anterior distal tibial edge was 0.5 mm, 3.9 mm, and 7.4 mm, respectively, without saline injection, and 3.7 mm, 7.2 mm, and 11.6 mm, respectively, with saline injection, in nondistraction. The distance was 2.2 mm, 5.9 mm, and 9.8 mm, respectively, with 5-kg distraction, and 1.7 mm, 5.1 mm, and 8.8 mm, respectively, with 10-kg distraction, both with saline injection, respectively. Conclusion: The distance between the anterior distal tibial edge and the ATA with joint space expansion by saline injection into the joint increased, and that distance in distraction of the ankle decreased during anterior arthroscopic surgery. Clinical Relevance: The anatomic relationship of the ATA to its surrounding structures may be at more risk without saline injection or with distraction during anterior ankle arthroscopy.
Pilot study to evaluate the potential use of the renal resistive index as a preliminary diagnostic tool for chronic kidney disease in cats
Authors: Matos Ines , Azevedo Pedro , Carreira L Miguel 
Published: October 2017

Objectives Chronic kidney disease (CKD) is the most common renal pathology diagnosed in geriatric cats, and its prevalence increases with age. The arterial resistive index (RI) is important when evaluating vascular resistance and compliance, and can be applied in the kidney (renal RI [RRI]), allowing the evaluation of its vascular haemodynamics. The present study aimed to: (1) investigate in cats with CKD the relationships between the RRI and the following parameters: age, sex, body weight, plasmatic creatinine, blood urea nitrogen, potassium, urine specific gravity, urine protein:creatinine ratio and systolic arterial pressure; and (2) evaluate the potential use of the RRI as a preliminary diagnostic tool in cats with CKD. Methods The present study involved 24 cats of both sexes. Six were healthy cats (control group [CG]) and 18 had CKD, but did not have any concomitant diseases and were not being treated with any medications (study group [SG]). For RRI measurement we used colour Doppler ultrasound (CDUS). Results RRI differed significantly between the CG and SG ( P <0.01) and was higher in the SG. A statistically significant correlation was only achieved between the RRI and the body weight of the patients and it was negative. A strong and positive correlation was noted between the mean RRI of both kidneys (r = 0.66). Receiver–operating curve analysis allowed us to establish an admissible cut-off for the RRI value of 0.639 for a preliminary diagnosis of CKD for both kidneys. Conclusions and relevance No differences were found for the RRI between the left and right kidneys, suggesting that evaluation of only one kidney is sufficient to provide an estimate of the RRI value for both organs. RRI measurement, which can be achieved with CDUS, is an easy-to-use diagnostic tool that, with a cut-off value of 0.639 for both kidneys, is useful in establishing a preliminary diagnosis of CKD.
Optimal duration of adjuvant endocrine therapy: how to apply the newest data
Authors: Wimmer Kerstin , Strobl Stephanie , Bolliger Michael , Devyatko Yelena , Korkmaz Belgin , Exner Ruth , Fitzal Florian , Gnant Michael 
Published: October 2017

Background: The benefit of 5 years of adjuvant endocrine therapy for women with hormone receptor-positive (HR+) breast cancer (BC) is beyond discussion. Nevertheless, the risk of recurrence of luminal BC persists for 15 years or more after diagnosis. Consequently, approaches of extended adjuvant therapy have been investigated in large clinical trials, with the ultimate aim of further reducing the risk of recurrence in patients with HR+ BC. Methods: A review of recently published trial data is presented to provide a solid basis for discussion. A discussion of the side effects of long-term endocrine treatment, multigenetic tests aiming to identify patients at particular risk, and an outlook for further promising targets are additional aims of this review. Conclusion: Extended adjuvant therapy seems beneficial in reducing distant relapse and contralateral BC for a selected group of patients with HR+ BC, particularly if aromatase inhibitors (AIs) are used after initial tamoxifen therapy. However, patients with lower risk of recurrence and initial AI therapy may suffer more from side effects than benefit from extended therapy.
Porous Titanium Wedges in Lateral Column Lengthening for Adult-Acquired Flatfoot Deformity
Authors: Moore Spencer H. , Carstensen S. Evan , Burrus M. Tyrrell , Cooper Truitt , Park Joseph S. , Perumal Venkat 
Published: October 2017

Lateral column lengthening (LCL) is a common procedure for reconstruction of stage II flexible adult-acquired flatfoot deformity (AAFD). The recent development of porous titanium wedges for this procedure provides an alternative to allograft and autograft. The purpose of this study was to report radiographic and clinical outcomes achieved with porous titanium wedges in LCL. A retrospective analysis of 34 feet in 30 patients with AAFD that received porous titanium wedges for LCL from January 2011 to October 2014. Deformity correction was assessed using both radiographic and clinical parameters. Radiographic correction was assessed using the lateral talo–first metatarsal angle, the talonavicular uncoverage percentage, and the first metatarsocuneiform height. The hindfoot valgus angle was measured. Patients were followed from a minimum of 6 months up to 4 years (mean 16.1 months). Postoperative radiographs demonstrated significant correction in all 3 radiographic criteria and the hindfoot valgus angle. We had no cases of nonunion, no wedge migration, and no wedges have been removed to date. The most common complication was calcaneocuboid joint pain (14.7%). Porous titanium wedges in LCL can achieve good radiographic and clinical correction of AAFD with a low rate of nonunion and other complications. Levels of Evidence: Level IV: Case series
Prognostic Value of the Neurological Examination in Cardiac Arrest Patients After Therapeutic Hypothermia
Authors: Matthews Elizabeth A. , Magid-Bernstein Jessica , Sobczak Evie , Velazquez Angela , Falo Cristina Maria , Park Soojin , Claassen Jan , Agarwal Sachin 
Published: October 2017

Objectives: Current prognostication guidelines for cardiac arrest (CA) survivors predate the use of therapeutic hypothermia (TH). The prognostic value and ideal timing of the neurological examination remain unknown in the setting of TH. Design: Patients (N = 291) admitted between 2007 and 2015 to Columbia University intensive care units for TH following CA had neurological examinations performed on days 1, 3, 5, and 7 postarrest. Absent pupillary light response (PLR), absent corneal reflexes (CRs), and Glasgow coma scores motor (GCS-M) no better than extension were considered poor examinations. Poor outcome was recorded as cerebral performance category score ≥3 at discharge and 1 year. Predictive values of examination maneuvers were calculated for each time point. Main Results: Among the 137 survivors to day 7, sensitivities and negative predictive values were low at all time points. The PLR had false positive rates (FPRs) of 0% and positive predictive values (PPV) of 100% from day 3 onward. For the CR and GCS-M, the FPRs decreased from day 3 to 5 (9% vs 3%; 21% vs 9%), while PPVs increased (91% vs 96%; 90% vs 95%). Excluding patients who died due to withdrawal of life-sustaining therapy (WLST) did not significantly affect FPRs or PPVs, nor did assessing outcome at 1 year. Conclusions: A poor neurological examination remains a strong predictor of poor outcome, both at hospital discharge and at 1 year, independent of WLST. Following TH, the predictive value of the examination is insufficient at day 3 and should be delayed until at least day 5, with some additional benefit beyond day 5.
c-MPL provides tumor-targeted T-cell receptor-transgenic T cells with costimulation and cytokine signals
Authors: Nishimura Christopher D. , Brenner Daniel A. , Mukherjee Malini , Hirsch Rachel A. , Ott Leah , Wu Meng-Fen , Liu Hao , Dakhova Olga , Orange Jordan S. , Brenner Malcolm K. , Lin Charles Y. , Arber Caroline 
Published: October 2017

Key Points
c-MPL enables tumor-directed TCR+ T cells to become sequential killers by improving immune synapses, costimulation, and cytokine signals. c-MPL activation improves in vivo persistence and antitumor function of adoptively transferred c-MPL+ TCR-transgenic T cells.
Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates
Authors: Kwun Jean , Burghuber Christopher , Manook Miriam , Ezekian Brian , Park Jaeberm , Yoon Janghoon , Yi John S. , Iwakoshi Neal , Gibby Adriana , Hong Jung Joo , Farris Alton B. , Kirk Allan D. , Knechtle Stuart J. 
Published: October 2017

Key Points
Targeting both PCs and GC response reduces donor-specific antibodies and prolongs graft survival in sensitized NHP kidney transplantation.
Placental Growth Factor Is Required for Ovulation, Luteinization, and Angiogenesis in Primate Ovulatory Follicles
Authors: Bender Hannah R , Trau Heidi A , Duffy Diane M 
Published: October 2017

AbstractPlacental growth factor (PGF) is member of the vascular endothelial growth factor (VEGF) family of angiogenesis regulators. VEGFA is an established regulator of ovulation and formation of the corpus luteum. To determine whether PGF also mediates aspects of ovulation and luteinization, macaques received gonadotropins to stimulate multiple follicular development. Ovarian biopsies and whole ovaries were collected before (0 hours) and up to 36 hours after human chorionic gonadotropin (hCG) administration to span the ovulatory interval. PGF and VEGFA were expressed by both granulosa cells and theca cells. In follicular fluid, PGF and VEGFA levels were lowest before hCG. PGF levels remained low until 36 hours after hCG administration, when PGF increased sevenfold to reach peak levels. Follicular fluid VEGFA increased threefold to reach peak levels at 12 hours after hCG, then dropped to intermediate levels. To explore the roles of PGF and VEGFA in ovulation, luteinization, and follicular angiogenesis in vivo, antibodies were injected into the follicular fluid of naturally developed monkey follicles; ovariectomy was performed 48 hours after hCG, with ovulation expected about 40 hours after hCG. Intrafollicular injection of control immunoglobulin G resulted in no retained oocytes, follicle rupture, and structural luteinization, including granulosa cell hypertrophy and capillary formation in the granulosa cell layer. PGF antibody injection resulted in oocyte retention, abnormal rupture, and incomplete luteinization, with limited and disorganized angiogenesis. Injection of a VEGFA antibody resulted in oocyte retention and very limited follicle rupture or structural luteinization. These studies demonstrate that PGF, in addition to VEGFA, is required for ovulation, luteinization, and follicular angiogenesis in primates.
A Correlation between Radiotherapy Dose on the Mediastinal Lymphoma and Cardiovascular Dose with Using Respiratory Control System
Authors: Филатова Е. , Filatova E. , Ламанова О , Lamanova O , Филатов П. , Filatov P. , Жеравин А. , Zheravin A. 
Published: October 2017

Purpose: To find a correlation between prescribed dose on the irradiation area and dose on heart and ascending aorta, using the "breath holding" method in classical radiotherapy course for patients with Hodgkin and non-Hodgkin mediastinal lymphomas.
Material and methods: For patients of reproductive age with diagnose Hodgkin, non-Hodgkin mediastinal lymphomas we conducted radiotherapy with contouring of tumor, and critical structures, include heart and ascending aorta. Radiotherapy was conducted on breath holding (ABC) for shielding radiation dose from heart, ascending aorta and lungs. We did calculations of length and diameter of the contoured aorta and dose that it and heart took. Also, we did correlation calculation of relationship between prescribed dose on the tumor and doses cover to the heart and aorta on 6 and 10 MV nominal energies.
Results: According to the protocol RTOG 1005 for the heart zone, exceeding the threshold level for V20 < 5 % occurred in 11 cases out 21, and 8 cases from them are for 10 MV energy. For V10 < 30 % it happened in nine cases from 21, and seven cases from them are for 10 MV energy too. The correlation coefficient between the prescribed dose and the received dose for protocol RTOG 1005 V10 < 30 % was 0.71 and it showed the highest value. This index is lower on 13 % for protocol RTOG 0623 (V67) – 0..58, and it has the weakest coefficient correlation (V33) – 0.45. The value of the correlation coefficient for the aorta decreased with an increase in the volume to which the prescribed dose of the irradiation area falls and, consequently a 10 and 20 % of the aorta volume is getting a maximum value from the prescribed dose.
Conclusion: Our research showed what contouring of ascending aorta is obligatorily procedure, because the average dose on it was 10.73 Gy for 10 MV and 6.50 Gy for 6 MV energies. It is obvious that using 6 MV energy is more organ-preserving method of thea radiotherapy treatment when using a such techniques as ABC. It is a very important to study the issue of the permissible dose per volume of ascending aorta without critical consequences for cardiovascular system. In addition, it particularly important if we take into account that all patients had a chemotherapy course before radiation therapy which also caused cardiotoxicity.