bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kajian skrining risiko hipertensi pada kehamilan menggunakan buku KIA pada usia kehamilan 20 minggu di Posyandu Batujaya
Authors: Karmilah Karmilah , Mochartini Tri 
Published: September 2024

Background: Hypertension in pregnancy if left unchecked can harm the pregnant mother and her fetus. Efforts to screen for hypertension in pregnant women through maternal and child health (KIA) books. Several factors related to hypertension are eating habits, smoking habits, stress, obesity and family history of the disease.
Purpose: To determine the study of hypertension risk screening in pregnancy using the KIA book at 20 weeks.
Method: Quantitative analytical research with cross sectional design. The sample in this study was pregnant women aged ≥ 20 weeks who underwent examinations at Posyandu Batujaya, Karawang Regency starting in December 2023, totaling 115 respondents, sampling using accidental sampling technique. The research instrument used a questionnaire and the data used were primary data and secondary data, analyzed using the quadratic test.
Results: It is known that there is a relationship between eating habits (p value = 0.037), smoking habits (p value = 0.000), stress (p value = 0.004), obesity (p value = 0.041) and family history of disease (p value = 0.000) with the incidence of hypertension in pregnancy at 20 weeks gestation.
Conclusion: Eating habits, smoking habits, stress, obesity, and family history of disease are associated with the incidence of hypertension in pregnancy at 20 weeks' gestation.

Keywords: 20 Weeks Gestation; Mother and Child Health Book; Pregnancy Hypertension Risk Screening.

Pendahuluan: Hipertensi dalam kehamilan jika dibiarkan bisa membahayakan ibu hamil dan janinnya. Upaya untuk melakukan skrining hipertensi pada ibu hamil melalui buku kesehatan ibu dan anak (KIA). Beberapa faktor yang berkaitan dengan hipertensi yakni kebiasaan makan, kebiasaan merokok, stres, obesitas dan riwayat penyakit keluarga.
Tujuan: Untuk mengetahui kajian skrining risiko hipertensi pada kehamilan menggunakan buku KIA pada usia kehamilan 20 minggu.
Metode: Penelitian analitik kuantitatif dengan desain cross sectional. Sampel dalam penelitian ini adalah ibu hamil usia kehamilan ≥ 20 minggu yang menjalani pemeriksaan di Posyandu Batujaya Kabupaten Karawang mulai bulan Desember 2023 yang berjumlah 115 responden, pengambilan sampel menggunakan teknik accidental sampling. Instrumen penelitian menggunakan kuesioner dan data yang digunakan adalah data primer dan data sekunder, dianalisis menggunakan uji kuadrat.
Hasil: Diketahui bahwa ada hubungan antara kebiasaan makan (p value = 0.037), kebiasaan merokok (p value = 0.000), stres (p value = 0.004), obesitas (p value = 0.041) dan riwayat penyakit keluarga (p value = 0.000) dengan kejadian hipertensi pada kehamilan pada usia kehamilan 20 minggu.
Simpulan: Kebiasaan makan, kebiasaan merokok, stres, obesitas, dan riwayat penyakit keluarga berhubungan dengan kejadian hipertensi pada kehamilan pada usia kehamilan 20 minggu.

Kata Kunci: Buku KIA; Skrining Risiko Hipertensi Kehamilan; Usia Kehamilan 20 Minggu.
Manfaat aktivitas fisik berbasis komunitas terhadap penderita diabetes mellitus: A scoping review
Authors: Ariyanti Rahmania Ulfi , Rahman Farid 
Published: September 2024

Background: Diabetes Mellitus (DM) is a metabolic disorder characterized by hyperglycemia. Type 2 DM occurs due to impaired insulin secretion that causes insulin resistance, occurs in 90-95% of diabetes cases and is often found in obese patients. Providing long-term, supervised community-based interventions can improve physical fitness and physical activity in people with DM.
Purpose: To review and evaluate the benefits of providing a community-based exercise program to reduce HbA1c levels in people with DM.
Method: Scoping review using PRISMA diagram. Research data collection through Google Scholar, PubMed, and Sciencedirect databases published in 2013-2023.
Results: There was a decrease in HbA1c levels and an increase in fitness in DM patients who underwent a community-based exercise program of aerobic exercise type with endurance in the heart rate range associated with VO2 max 65% - 85% and a moderate to strong intensity range.
Conclusion: Community-based exercise programs are indicated to reduce HbA1c levels in DM patients.
Suggestion: This literature review is expected to be a reference in providing types of community-based exercise in the form of aerobic exercise programs or a combination of community-based aerobic and strengthening exercise programs carried out for a duration of 150 minutes in one week, with moderate to high intensity adjusted to the conditions of DM participants.

Keywords: Community; Diabetes Mellitus; Exercise; Physical Fitness.

Pendahuluan: Diabetes Mellitus (DM) merupakan kondisi gangguan metabolisme yang ditandai dengan hiperglikemia. DM tipe 2 terjadi karena kerusakan sekresi insulin yang menyebabkan terjadinya resistensi insulin, terjadi pada 90-95% kasus diabetes serta banyak ditemukan pada penderita dengan obesitas. Pemberian intervensi berbasis komunitas jangka panjang yang diawasi dapat meningkatkan kebugaran fisik dan meningkatkan aktivitas fisik pada penderita DM.
Tujuan: Untuk meninjau dan mengevaluasi manfaat pemberian program latihan berbasis komunitas untuk menurunkan kadar HbA1c pada penderita DM.
Metode: Scoping review menggunakan panduan diagram PRISMA. Pengumpulan studi melalui database Google Scholar, PubMed, dan Sciencedirect yang diterbitkan pada tahun 2013- 2023.
Hasil: Adanya penurunan kadar HbA1c dan peningkatan kebugaran pada penderita DM yang melakukan program latihan berbasis komunitas jenis latihan aerobik disertai resistensi dalam rentang detak jantung yang terkait dengan 65% - 85% VO2 max dan rentang intensitas sedang hingga kuat.
Simpulan: Program latihan berbasis komunitas terindikasi dapat menurunkan kadar HbA1c pada penderita DM.
Saran: Literature review ini diharapkan dapat menjadi referensi dalam pemberian jenis latihan berbasis komunitas berupa program latihan aerobik atau program kombinasi latihan aerobik dan penguatan berbasis komunitas yang dilakukan dengan durasi 150 menit dalam satu minggu, intensitas sedang sampai berat disesuaikan dengan kondisi peserta penderita DM.
تأثير منهج تعليمي بوسائل مساعدة في تعلّم مهارة الدفاع عن الملعب بالكُرة الطائرة للطلاب
Authors: Asst. Lec. Zaid Khalifa Abd  , Prof. Dr. Thaer Rashid Hassan  , Prof. Dr. Mujahid Hamid Rashid  
Published: September 2024

يهدف البحث إِلى إعداد منهج تعليمي بوسائل مساعدة في تعلّم مهارة الدفاع عن الملعب بالكُرة الطائرة للطلاب، وتعرف على تأثير منهج تعليمي بوسائل مساعدة في تعلّم مهارة الدفاع عن الملعب بالكُرة الطائرة للطلاب، اعتمد الباحثون المنهج التجريبي لملائمته طبيعة المشكلة التي تُعدُّ واحدة من أفضل الوسائل من أَجل الحصول على معلومات ونتائج دقيقة للوصول إِلى معرفة علمية موثوقة، وتمثل مجتمع البحث بطلاب السنة الدراسية الثانية في كليّة التربيّة البدنيّة وعلوم الرياضة/جامعة ديالى للعام الدراسي 2022/2023 البالغ عددهم (187) طالب يمثلون (5) شعب دراسية، تَمَّ اختيار شعبتي (د،ه) بالطريقة العشوائية عن طريق القرعة من بين (5) شعب، واختيرت عينة البحث بالطريقة ذاتها من كِلا الشعبتين (30) تمثل نسبة (16.042%) من إجمالي المجتمع البحثي للطلاب (187) مع عدد الطلاب، بواقع (15) طالب من شعبة (د) يُمثلون المجموعة التجريبية التي نفذت مفردات المنهج التعليميّ بوسائل مساعدة ، و(15) طالب من شعبة (ه) يُمثلون المجموعة الضابطة التي نفذت منهج الكليّة، عن طريق ما أظهرته نتائج البحث وفي ضوء أهدافه وفروضه توصل الباحثون إِلى استنتاجات عِدَّة أهمها إِنَّ للمنهج التعليمي بوسائل مساعدة تأثير فعال في تعلّم مهارة الدفاع عن الملعب بالكُرة الطائرة، إِنَّ التمرينات المهارية المعدة ضمن المنهج التعليمي تأثير في تعلّم مهارة الدفاع عن الملعب في الكُرة الطائرة لطلاب السنة الدراسية الثانية، إِنَّ للوسائل المساعدة التي تَمَّ اعتمادها التأثير على تنفيذ تمارين الوحدة التعليمية لمهارات الدفاع عن الملعب في الكُرة الطائرة لطلاب السنة الدراسية الثانية، في ضوء ما أسفرت عنه نتائج البحث والاستنتاجات يوصى الباحثون بأهم التوصيات ضرورة تنويع الوسائل المساعدة المستعملة في التدريس.
ذكاء الجسم الحركي وعلاقته بمستوى اداء مهارتي القفز (فتحاً وضماً) على جهاز القفز في الجمناستك الفني للطلاب
Authors: Lec. Dr. Khaled Mohamed Ahmed  
Published: September 2024

هدفت الدراسة الى التعرف على العلاقة بين الذكاء الجسمي الحركي ومستوى اداء مهارتي القفز (فتحاً وضماً) على جهاز القفز في الجمناستك الفني للطلاب. حيث قام الباحث باختيار المنهج الوصفي بالأسلوب العلاقة الارتباطية وتم اختيار مجتمع البحث بالطريقة العمدية من طلاب المرحلة الثالثة في كلية التربية البدنية وعلوم الرياضة في جامعة صلاح الدين – اربيل للعام الدراسي (2023-2024)، وقد استخدم الباحث الوسائل الاحصائية المناسبة، اذ استخدم الحقيبة الاحصائية Spss . وقد توصل الباحث الى الاستنتاج التالي وهي انه هناك علاقة معنوية عالية بين الذكاء الجسمي الحركي ومستوى مهارتي (القفز فتحاً وضماً) على جهاز القفز في الجمناستك الفني للطلاب. وعلى ضوء هذا الاستنتاج وضع الباحث مجموعة من التوصيات وهي اعطاء الذكاء الجسمي الحركي اهمية أكثر خلال تعليم الطلاب لمهارات الجمناستك والاخذ بأساليب تعليمية جديدة من اجل تحسين الذكاء الجسمي الحركي لدى الطلاب والطالبات واجراء بحوث اخرى تركز على العمليات العقلية وخاصة المتعلقة بالذكاء.
The time dependent influence of curvature and topography of biomaterials in the behavior of corneal endothelial cells
Authors: Bosch Begoña M. , Delgado Luis M. , Rodríguez-González Raquel , Perez Roman A. 
Published: September 2024

Among the different layers of the cornea, the corneal endothelium, which is composed of corneal endothelial cells (CEC), plays a key role in the maintenance of cornea transparency. Based on the donor shortages and the limitations associated with transplantation, in this work we have developed collagen hydrogels with different patterned structures on the surface to provide topographies in ranges similar to the natural environment that CEC sense. This aimed at stimulating cells to maintain a typical CEC phenotype and provide alternatives to corneal transplantation. In this sense, we have elaborated curved collagen hydrogels (concave and convex) with three different topographies (50, 200 and 300 µm grooves), with the help of 3D printed mold and replicating the mold with the collagen hydrogel, onto which CEC were cultured in order to analyze its behavior. Flat hydrogels were used as controls. Cell morphology, cell circularity and gene expression of ATP1A1 and ZO-1 genes were analyzed after 3 and 6 days. Results showed an effect of the curvature and the topography compared to flat collagen hydrogels, showing higher expression of ZO-1 and ATP1A1 in curved non-patterned hydrogels at day 3. The patterned hydrogels did not have such a significant effect on gene expression compared to flat hydrogels, showing stronger effect of the curvature compared to the topography. The effect was opposite at day 6, showing higher gene expression at days 6 on the patterned hydrogels, especially for the ZO-1 gene. The gene expression results were in accordance with the cell morphology observed at the different time points, showing circularities closer to hexagon like morphology at shorter time points. Overall, this platform can serve as a system to culture cell under proper environment to further be able to transplant a CEC monolayer or to allow transplantation of thin collagen layers with cultured CEC.
Co-complexes on modified graphite surface for steady green hydrogen production from water at neutral pH
Authors: Toledo-Carrillo Esteban A. , García-Rodríguez Mario , Morallón Emilia , Cazorla-Amorós Diego , Ye Fei , Kundi Varun , Kumar Priyank V. , Verho Oscar , Dutta Joydeep , Åkermark Bjorn , Das Biswanath 
Published: September 2024

Green hydrogen production from water is one attractive route to non-fossil fuel and a potential source of clean energy. Hydrogen is not only a zero-carbon energy source but can also be utilized as an efficient storage of electrical energy generated through various other sources, such as wind and solar. Cost-effective and environmentally benign direct hydrogen production through neutral water (∼pH 7) reduction is particularly challenging due to the low concentration of protons. There is currently a major need for easy-to-prepare, robust, as well as active electrode materials. Herein we report three new molecular electrodes that were prepared by anchoring commercially available, and environmentally benign cobalt-containing electrocatalysts with three different ligand frameworks (porphyrin, phthalocyanine, and corrin) on a structurally modified graphite foil surface. Under the studied reaction conditions (over 7 h at 22°C), the electrode with Co-porphyrin is the most efficient for the water reduction with starting ∼740 mV onset potential (OP) (vs. RHE, current density 2.5 mA/cm2) and a Tafel slope (TS) of 103 mV/dec. It is followed by the molecular electrodes having Co-phthalocyanine [825 mV (OP), 138 mV/dec (TS)] and Vitamin-B12 (Co-corrin moiety) [830 mV (OP), 194 mv/dec (TS)]. A clear time-dependent improvement (&gt;200 mV over 3 h) in the H2 production overpotential with the Co-porphyrin-containing cathode was observed. This is attributed to the activation due to water coordination to the Co-center. A long-term chronopotentiometric stability test shows a steady production of hydrogen from all three cathode surfaces throughout seven hours, confirmed using an H2 needle sensor. At a current density of 10 mA/cm2, the Co-porphyrin-containing electrode showed a TOF value of 0.45 s−1 at 870 mV vs. RHE, whereas the Co-phthalocyanine and Vitamin-B12-containing electrodes showed 0.37 and 0.4 s−1 at 1.22 V and 1.15 V (vs. RHE), respectively.
Causal relationship between gut microbiota and insulin-like growth factor 1: a bidirectional two-sample Mendelian randomization study
Authors: Zheng Xuejie , Qian Yuping , Wang Lili 
Published: September 2024

BackgroundThe causal relationship between gut microbiota and insulin-like growth factor 1 (IGF-1) remains unclear. The purpose of this study was to explore the causal relationship between gut microbiota and IGF-1 in men and women.MethodsSingle-nucleotide polymorphisms (SNPs) related to gut microbiota were derived from pooled statistics from large genome-wide association studies (GWASs) published by the MiBioGen consortium. Pooled data for IGF-1 were obtained from a large published GWAS. We conducted Mendelian randomization (MR) analysis, primarily using the inverse variance weighted (IVW) method. Additionally, we performed sensitivity analyses to enhance the robustness of our results, focusing on assessing heterogeneity and pleiotropy.ResultsIn forward MR analysis, 11 bacterial taxa were found to have a causal effect on IGF-1 in men; 14 bacterial taxa were found to have a causal effect on IGF-1 in women (IVW, all P &lt; 0.05). After false discovery rate (FDR) correction, all bacterial traits failed to pass the FDR correction. In reverse MR analysis, IGF-1 had a causal effect on nine bacterial taxa in men and two bacterial taxa in women respectively (IVW, all P &lt; 0.05). After FDR correction, the causal effect of IGF-1 on order Actinomycetales (PFDR= 0.049) remains in men. The robustness of the IVW results was further confirmed after heterogeneity and pleiotropy analysis.ConclusionOur study demonstrates a bidirectional causal link between the gut microbiota and IGF-1, in both men and women.
Exploring the influencing factors of non-insulin drug prescriptions in discharged patients with type 1 diabetes
Authors: Cheng Yikang , Li Haizhen , Liu Xin , Jin Xiaolong , Han Junming , Du Jing , Xu Chao 
Published: September 2024

ObjectiveThe aim of this study was to evaluate the admission indicators and characteristics of individuals diagnosed with type 1 diabetes (T1D) to ascertain potential impact on the choice of glucose control therapy after discharge.MethodsA total of 398 eligible T1D patients were selected. We conducted multivariable logistic regression analysis to determine the independent influence of predictors on the selection of glucose control therapy after discharge. To explore the influencing factors of different subgroups, we additionally performed subgroup analyses based on gender and age.ResultsOur study revealed that body mass index (BMI) was noteworthy influence factor for prescription of insulin and non-insulin antidiabetic drug (NIAD prescription) in T1D patients of general population [OR = 1.109 (1.033-1.195), p = 0.006], male [OR = 1.166 (1.040−1.318), p = 0.011] and individuals below the age of 30 years [OR = 1.146 (1.020−1.301), p = 0.028]. Diastolic blood pressure (DBP) was a protective factor for NIAD prescription in the general population [OR = 0.971 (0.949-0.992), p = 0.008] and women [OR = 0.955 (0.923−0.988), p = 0.008]. The other risk factor of NIAD prescription in men was dyslipidemia [OR = 4.824 (1.442−22.246), p = 0.020]. Pulse pressure [OR = 1.036 (1.007–1.068), p = 0.016] constituted an additional risk factor of NIAD prescription among individuals below the age of 30 years. The risk factors of NIAD prescription for people aged 30 to 50 years were length of stay [OR = 1.097 (1.014–1.196), p = 0.026] and initial blood glucose [OR = 1.078 (1.007–1.168), p = 0.047]. In the case of individuals aged above 50 years, physicians exhibited a higher tendency to prescribe supplementary non-insulin medications to men [OR = 9.385 (1.501–87.789), p = 0.029].ConclusionsWe identified notable factors that influence discharge prescriptions in patients with T1D. In order to enhance the treatment outcome for the patient, clinicians ought to have a special focus on these indicators or factors.
Cost-benefit analysis of working with recovery in river management using Marxan
Authors: Agnew Danelle , Fryirs Kirstie , Leishman Michelle R. 
Published: September 2024

With the impact and cost of continued river degradation and climate change-induced extreme rainfall and floods, there is growing urgency to achieve and maintain good river health to meet global sustainable development goals. Up-scaling and working with nature-based solutions at regional, catchment and fluvial corridor scales is critical. One way to achieve this is to work within a recovery-enhanced approach to river rehabilitation, incorporating processes of geomorphic and vegetative recovery to build fluvial corridors in areas where they have become fragmented. Geomorphologically-informed cost-benefit analysis has not previously been applied in a riverine or riparian context, at the catchment or regional scale needed. We applied Marxan in a novel manner to undertake the first cost-benefit analysis for geomorphologically-informed rehabilitation of river systems. We estimated that to rehabilitate 75,500 km of streams in coastal catchments of NSW will cost $8.2 billion, comparing favourably to recent single flood event insurance losses, and projected future losses. We developed Marxan scenarios based on three broad approaches to river management: ad hoc and reactive, working with recovery and corridors, across current and future time periods. We found there are considerable current and flow-on future financial and non-financial benefits, and lower initial total and per-hectare rehabilitation costs, by fully adopting working with recovery or corridors approaches and moving away from the ad hoc and reactive approaches which dominate current practice. Implementing targeted rehabilitation based on a rolling sequence over time of corridors scenarios provides optimal holistic solutions to improve geomorphic condition and enhance recovery potential at landscape-scale. Our study demonstrates the use of Marxan as an accessible tool to address prioritisation complexity, and to run and cost landscape-scale rehabilitation scenarios over time. Our study also demonstrates the positive offsite feedbacks that occur through multiplier effects, as recovery occurs, and corridors are built. Geomorphologically-informed decision making becomes more robust, transparent, cost-effective, consistent across catchments, and adaptive to local situations and evolving river management priorities.
Quantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation
Authors: Matern Benedict M. , Spierings Eric , Bandstra Selle , Madbouly Abeer , Schaub Stefan , Weimer Eric T. , Niemann Matthias 
Published: September 2024

IntroductionModern histocompatibility algorithms depend on the comparison and analysis of high-resolution HLA protein sequences and structures, especially when considering epitope-based algorithms, which aim to model the interactions involved in antibody or T cell binding. HLA genotype imputation can be performed in the cases where only low/intermediate-resolution HLA genotype is available or if specific loci are missing, and by providing an individuals’ race/ethnicity/ancestry information, imputation results can be more accurate. This study assesses the effect of imputing high-resolution genotypes on molecular mismatch scores under a variety of ancestry assumptions.MethodsWe compared molecular matching scores from “ground-truth” high-resolution genotypes against scores from genotypes which are imputed from low-resolution genotypes. Analysis was focused on a simulated patient-donor dataset and confirmed using two real-world datasets, and deviations were aggregated based on various ancestry assumptions.ResultsWe observed that using multiple imputation generally results in lower error in molecular matching scores compared to single imputation, and that using the correct ancestry assumptions can reduce error introduced during imputation.DiscussionWe conclude that for epitope analysis, imputation is a valuable and low-risk strategy, as long as care is taken regarding epitope analysis context, ancestry assumptions, and (multiple) imputation strategy.