bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparticipation Sports Physicals: A Comparison of Single Provider and Station-Based Models
Authors: Lick David , Abdel-Aty Karim , Diaz Daniel , Dulku Jaspaul , Lochub Sandeep , Mir Kamran , Ricketts Robert 
Published: July 2017

Background:
Preparticipation physical examinations (PPEs) are required for children and adolescents before sports participation to identify at-risk athletes. These evaluations can be completed in a traditional office-based setting or in a station-based format. It is unclear if one format is superior to the other in identifying at-risk athletes.

Methods:
We performed a retrospective chart review of children and adolescents between the ages 10 and 18 years who received their PPE in our office or in a station-based setting in a local high school between the years 2009 and 2015.

Results:
We reviewed 2934 PPEs total, 1136 in the office-based format and 1798 in the station-based setting. A similar proportion of athletes were excluded or required further evaluation before participation in the office compared with the station-based setting (4.84% vs 5.67%). No statistically significant associations were seen between site of PPE or athlete sex and rate of clearance. There was, however, a statistically significant association between PPE site and reason for exclusion (P = 0.0456) with higher rates of exclusion for vision-related issues in the station-based setting and higher rates of exclusion for musculoskeletal or cardiopulmonary reasons in the office-based setting.

Conclusion:
When conducted by the same examiners, the office-based and team-based PPE excluded or referred equal number of athletes, although the reason for further evaluation does differ based on setting.
Human Papillomavirus Prevalence Is Associated With Socioeconomic Gradients Within a Medically Underserved Appalachian Region
Authors: Ware S. Lee , Crosby Richard , Fisher Rebecca , Hagensee Michael E. 
Published: July 2017

Objectives
To assess type-specific prevalence of human papillomavirus (HPV) infection in a medically underserved Appalachian area and to determine whether gradients in poverty are associated with prevalence.

Methods
Among 398 women, a validated assay tested self-collected cervicovaginal samples for 37 HPV types. Three economic strata were created based on household income: below the federal poverty level for 1 person, between the FPLs for families of 1 to 4 persons, and above the FPL for a family of 4.

Results
Prevalence was 55.6%, with 33% having at least 1 high-risk infection. Prevalence was 27.8% for 9-valent HPV vaccine–preventable types and 39.2% for multiple types. Compared with FPL for a family of 4, women with federal poverty level for 1 person had 3 times greater prevalence, 2.3 times greater prevalence of high-risk types, and 2.5 times greater prevalence of multiple types.

Conclusion
Human papillomavirus prevalence was high, with one-third of the sample having at least 1 high-risk type and those in the lowest-income category being disproportionately infected.
Simultaneous Physical and Mental Effort Alters Visual Function
Authors: Vera Jesús , Jiménez Raimundo , García José Antonio , Cárdenas David 
Published: July 2017

PURPOSE
Perceptual processing is sensitive to physiological changes. Thus, the homeostatic disturbances during and after exercise may alter the visual function. Here, we investigated the effect of simultaneous physical effort and two levels of cognitive demand on skills related to the visuoperceptual and motor processing.

METHODS
Eighteen male regular exercisers performed 60 minutes of simultaneous physical exercise (cycling at 60 ± 5% of reserve heart rate) and cognitive effort (mental workload). The same protocol was performed with a mental workload and an oddball condition of this task on different days in a counterbalanced manner. We assessed the near point of convergence, near stereoacuity, accommodative facility (Hart Charts), and eye-hand coordination before and after the two dual-tasking sessions. Also, we calculated cognitive-performance scores and subjective measures of mental load.

RESULTS
We found that the near point of convergence (break and recovery) is significantly (P ≤ .05) reduced after physical and mental effort independently of the mental level administered. Only the condition of mental workload with simultaneous constant-intensity cycling promoted a significant impairment in the near stereoacuity and the eye-hand coordination (P = .006 and P = .018, respectively); however, these two parameters did not significantly change under the oddball condition. The accommodative facility showed an improvement in the oddball and mental workload conditions (P < .001 and P = .006, respectively). Confirming a successful experimental manipulation, participants experienced higher mental demand and arousal and achieved lower scores on cognitive performance during the mental workload task (both P < .001).

CONCLUSIONS
The visual function is affected by simultaneous physical and mental effort, the manipulation of mental-task complexity being an important modulator of this effect. Both dual tasks, physical with or without mental workload demands, may enhance or impair visual and motor processing depending on the visual parameter tested, and those changes could be related to the activation state of the nervous system.
Development of Systemic Inflammatory Polyarthritis After Zygapophyseal Joint Injection With Hylan G-F 20 (Synvisc-One)
Authors: Kocak Denizen , Annaswamy Thiru , Chong Sharon , Arora Rashmi 
Published: July 2017

Abstract
Hylan G-F 20 (Synvisc-One) is a hyaluronic acid derivative used for viscosupplementation of synovial fluid in osteoarthritic joints. Injection of hylan G-F 20 is Federal Drug Administration approved for use in knee osteoarthritis and is generally well tolerated with few reported adverse effects, the most common being local pain or swelling. We present the case of a 72-year-old man with bilateral, diffuse, joint pain and swelling with elevated inflammatory markers suggestive of a systemic inflammatory polyarthropathy that developed acutely 2 days after lumbar zygapophyseal joint injection with hylan G-F 20. Systemic effects after hylan G-F 20 injection have not been well documented, and this is the first reported case of systemic inflammatory polyarthritis after injection, to our knowledge. Further research is needed to better establish the safety and efficacy of lumbar zygapophyseal joint injections with hylan G-F 20.
Challenges in Translating PrEP Interest Into Uptake in an Observational Study of Young Black MSM
Authors: Rolle Charlotte-Paige , Rosenberg Eli S. , Siegler Aaron J. , Sanchez Travis H. , Luisi Nicole , Weiss Kevin , Cutro Scott , del Rio Carlos , Sullivan Patrick S. , Kelley Colleen F. 
Published: July 2017

Background:
HIV incidence among US young, black men who have sex with men (YBMSM) is high, and structural barriers (eg lack of health insurance) may limit access to Pre-exposure prophylaxis (PrEP). Research studies conducted with YBMSM must ensure access to the best available HIV prevention methods, including PrEP.

Methods:
We implemented an optional, nonincentivized PrEP program in addition to the standard HIV prevention services in a prospective, observational cohort of HIV-negative YBMSM in Atlanta, GA. Provider visits and laboratory costs were covered; participant insurance plans and/or the manufacturer assistance program were used to obtain drugs. Factors associated with PrEP initiation were assessed with prevalence ratios and time to PrEP initiation with Kaplan–Meier methods.

Results:
Of 192 enrolled YBMSM, 4% were taking PrEP at study entry. Of 184 eligible men, 63% indicated interest in initiating PrEP, 10% reported no PrEP interest, and 27% wanted to discuss PrEP again at a future study visit. Of 116 interested men, 46% have not attended a PrEP initiation appointment. Sixty-three men (63/184; 34%) initiated PrEP; 11/63 (17%) subsequently discontinued PrEP. The only factor associated with PrEP initiation was reported sexually transmitted infection in the previous year (prevalence ratio 1.50, 95% confidence interval: 1.002 to 2.25). Among interested men, median time to PrEP initiation was 16 weeks (95% confidence interval: 7 to 36).

Conclusions:
Despite high levels of interest, PrEP uptake may be suboptimal among YBMSM in our cohort even with amelioration of structural barriers that can limit use. PrEP implementation as the standard of HIV prevention care in observational studies is feasible; however, further research is needed to optimize uptake for YBMSM.
Secondary Palatal Elongation: Improvement in Speech Quality
Authors: Çelik Muzaffer 
Published: July 2017

Abstract
Cleft palate is one of the challenging problems in the field of craniofacial surgery. In particular, the conventional methods of bilateral and severe cleft palate repairs have failed to achieve normal speech. In most instances, secondary procedures such as pharyngoplasty and pharyngeal flap surgery are performed to improve speech.
This study introduces secondary palatal elongation (SPE) as a new approach to cleft palate repair. The patients included usually had a short palate and unrepaired palatal muscles. The authors’ procedure involved dissecting the previously repaired palatal mucosa and pushing back and cutting the nasal mucosa of the palate horizontally and further pushing it back. Then, 1 or 2 buccal mucosal flaps were used to repair the nasal mucosal defect of the palate. In case of unrepaired veloplasty from the primary surgery, the levator muscles were dissected and sutured together to perform veloplasty. The range of palatal elongation was 15 to 25 mm.
Secondary palatal elongation has been performed on 17 patients since 2007 with a high rate of speech improvement. Based on this 9-year experience with performing SPE, SPE is a radical anatomic technique of palatal elongation as compared with pharyngoplasty and pharyngeal flap surgery. All 17 patients who underwent SPE showed improvement in speech, from very poor to poor speech and from normal to good speech.
Rare Complication in Third Maxillary Molar Extraction: Dislocation in Infratemporal Fossa
Authors: Battisti Andrea , Priore Paolo , Giovannetti Filippo , Barbera Giorgio , D’Alessandro Francesco , Valentini Valentino 
Published: July 2017

Aim:
Removal of impacted third maxillary molar is frequently carried out without difficulties and low rate of intraoperative complications. The rare and particularly challenger to manage it is the third molar dislocation into the infratemporal fossa (IF). In this clinical report, the authors present their solution to manage and resolve this particular complication.

Methods:
A 28-year-old woman was referred to the emergency rescue unit of the authors’ hospital by her dentistry, after the attempt to extract the left impacted maxillary third molar. During the procedure the tooth accidentally dislodged and was lost sight of it. The patient had significant mouth-opening limitation, omolateral mid face swelling and pain. Computer tomography was immediately performed to determine the exact position of the tooth, showing the dental element dislocated into the IF.

Results:
Considering all of possible complications the best surgical option must guarantee a direct approach and a constant eye contact of the tooth, even in case of further displacement during the procedure, and allow early surgery. The authors used an endoscopic transoral approach through the preexisted access and solved all the issues reducing morbidity.

Conclusion:
Removing tooth from the IF could be burdened by serious risk of bleeding and/or nerve injury. The endoscopic approach provides direct view of the IF reducing morbidity.
A National Survey on Peri-interventional Management of Percutaneous Transhepatic Biliary Drainage
Authors: Pek Chulja J. , van Dijk Monique , Groot Koerkamp Bas , Moelker Adriaan , van Eijck Casper H.J. 
Published: July 2017

Purpose:
The purpose of this study is to evaluate knowledge about management of percutaneous transhepatic biliary drainage (PTBD) catheters among nurses taking care of hepato-pancreato-biliary (HPB) patients.

Methods:
Six HPB nurses from the Dutch national HPB association created a questionnaire that was complemented by 2 HPB surgeons, 3 HPB interventional radiologists, and a methodologist. Registered nurses working at the department of gastroenterology or gastrointestinal surgery and familiar with the care for HPB patients were invited to complete the questionnaire.

Results:
In total 120 completed questionnaires from Dutch nurses were returned. The responders were working in 38 of 64 different hospitals. About half of the respondents considered their own knowledge insufficient, which was reflected in the response to the specific questions concerning the PTBD procedure, and 70% rated the knowledge of their immediate nursing colleagues as insufficient. Less than 50% of the respondents knew whether antibiotic-prophylaxis or “pain medication” was required before PTBD procedure. Only a few respondents were aware of the existence of a hospital protocol for PTBD management and its content.

Conclusions:
Nursing care for biliary catheters is not standardized nationwide, and consensus on management is lacking. An evidence-based guideline for PTBD management is advised for nursing care of patients with HPB diseases.
A mental number line in human newborns
Authors: Rugani Rosa , Lunghi Marco , Di Giorgio Elisa , Regolin Lucia , Dalla Barba Beatrice , Vallortigara Giorgio , Simion Francesca 
Published: July 2017

ABSTRACTIn the 19thcentury Francis Galton first reported that humans represent numbers on a mental number line with smaller numbers on the left and larger numbers on the right. It has been suggested that this orientation emerges as a result of reading/writing habits for both words or numbers. Recent evidence in animals and infants in the first months of life has challenged the primary role of language in determining the left-to-right direction of spatial-numerical association, SNA. However, the possibility that SNA is learnt by early exposure to caregivers’ directional biases is still open. Here we show that 55-hour-old newborns, once habituated to a number (i.e., 12), spontaneously associated a smaller number (i.e., 4) with the left side and a larger number (i.e., 36) with the right side of space. Moreover, SNA in neonates was not absolute but relative. The same number (i.e., 12) was associated with the left side whenever the previously experienced number was larger (i.e., 36), but with the right side whenever the number was smaller (i.e., 4). Control on continuous physical variables showed that the effect was specific of discrete magnitudes. Hence, soon after birth humans associate smaller numbers with the left space and larger numbers with the right space. These results constitute strong evidence that in our species SNA originates from pre-linguistic and biologically precursors in the brain.SIGNIFICANCE STATEMENTFor human adults, the representation of number and space is profoundly intertwined. Humans represent numbers on a left to right oriented Mental Number Line (MNL), with small numbers located on the left and larger ones on the right. How do these connections arise? Do we learn to associate numbers with space throughout cultural learning and social interactions or is this association rooted in the biology of the human brain? We showed that neonates spontaneously associate numbers with space. After being habituated to a certain number, neonates associated a smaller number with the left and a larger number with the right side. This evidence demonstrates that a predisposition to map numbers onto space is rooted in human neural systems.
Aether: Leveraging Linear Programming for Optimal Cloud Computing In Genomics
Authors: Luber Jacob M. , Tierney Braden T. , Cofer Evan M. , Patel Chirag J. , Kostic Aleksandar D. 
Published: July 2017

AbstractAcross biology we are seeing rapid developments in scale of data production without a corresponding increase in data analysis capabilities. Here, we present Aether (http://aether.kosticlab.org), an intuitive, easy-to-use, cost-effective, and scalable framework that uses linear programming (LP) to optimally bid on and deploy combinations of underutilized cloud computing resources. Our approach simultaneously minimizes the cost of data analysis while maximizing its efficiency and speed. As a test, we used Aether tode novoassemble 1572 metagenomic samples, a task it completed in merely 13 hours with cost savings of approximately 80% relative to comparable methods.
Principal Metabolic Flux Mode Analysis
Authors: Bhadra Sahely , Blomberg Peter , Castillo Sandra , Rousu Juho 
Published: July 2017

AbstractMotivationIn the analysis of metabolism using omics data, two distinct and complementary approaches are frequently used: Principal component analysis (PCA) and Stoichiometric flux analysis. PCA is able to capture the main modes of variability in a set of experiments and does not make many prior assumptions about the data, but does not inherently take into account the flux mode structure of metabolism. Stoichiometric flux analysis methods, such as Flux Balance Analysis (FBA) and Elementary Mode Analysis, on the other hand, produce results that are readily interpretable in terms of metabolic flux modes, however, they are not best suited for exploratory analysis on a large set of samples.ResultsWe propose a new methodology for the analysis of metabolism, called Principal Metabolic Flux Mode Analysis (PMFA), which marries the PCA and Stoichiometric flux analysis approaches in an elegant regularized optimization framework. In short, the method incorporates a variance maximization objective form PCA coupled with a Stoichiometric regularizer, which penalizes projections that are far from any flux modes of the network. For interpretability, we also introduce a sparse variant of PMFA that favours flux modes that contain a small number of reactions. Our experiments demonstrate the versatility and capabilities of our methodology.AvailabilityMatlab software for PMFA and SPMFA is available inhttps://github.com/aalto-ics-kepaco/PMFA.Contactsahely@iitpkd.ac.in,juho.rousu@aalto.fi,Peter.Blomberg@vtt.fi,Sandra.Castillo@vtt.fiSupplementary informationDetailed results are in Supplementary files. Supplementary data are available athttps://github.com/aalto-ics-kepaco/PMFA/blob/master/Results.zip.
Thrombopoietin signaling to chromatin elicits rapid and pervasive epigenome remodeling within poised chromatin architectures
Authors: Comoglio Federico , Park Hyun Jung , Schoenfelder Stefan , Barozzi Iros , Bode Daniel , Fraser Peter , Green Anthony R. 
Published: July 2017

AbstractThrombopoietin (TPO) is a critical cytokine regulating hematopoietic stem cell maintenance and differentiation into the megakaryocytic lineage. However, the transcriptional and chromatin dynamics elicited by TPO signaling are poorly understood. Here, we study the immediate early transcriptional and cis-regulatory responses to TPO in hematopoietic stem/progenitor cells (HSPCs) and use this paradigm of cytokine signaling to chromatin to dissect the relation between cis-regulatory activity and chromatin architecture. We show that TPO profoundly alters the transcriptome of HSPCs, with key hematopoietic regulators being transcriptionally repressed within 30 minutes of TPO. By examining cis-regulatory dynamics and chromatin architectures, we demonstrate that these changes are accompanied by rapid and extensive epigenome remodeling of cis-regulatory landscapes that is spatially coordinated within topologically associating domains (TADs). Moreover, TPO-responsive enhancers are spatially clustered and engage in preferential homotypic intra‐ and inter-TAD interactions that are largely refractory to TPO signaling. By further examining the link between cis-regulatory dynamics and chromatin looping, we show that rapid modulation of cis-regulatory activity is largely independent of chromatin looping dynamics. Finally, we show that, although activated and repressed cis-regulatory elements share remarkably similar DNA sequence compositions, transcription factor binding patterns accurately predict rapid cis-regulatory responses to TPO.
Mixtures are more salient stimuli in olfaction
Authors: Chan Ho Ka , Nowotny Thomas 
Published: July 2017

AbstractIn their natural environment, animals often encounter complex mixtures of odours. It is an open question whether and how responses to complex mixtures of multi-component odours differ from those to simpler mixtures or single components. To approach this question, we built a full-size model of the early olfactory system of honeybees, which predicts responses to both single odorants and mixtures. The model is designed so that olfactory response patterns conform to the statistics derived from experimental data for a variety of their properties. It also takes into account several biophysical processes at a minimal level, including processes of chemical binding and activation in receptors, and spike generation and transmission in the antennal lobe network. We verify that key findings from other experimental data, not used in building the model, are reproduced in it. In particular, we replicate the strong correlation among receptor neurons and the weaker correlation among projection neurons observed in experimental data and show that this decorrelation is predominantly due to inhibition by interneurons. By simulation and mathematical analysis of our model, we demonstrate that the chemical processes of receptor binding and activation already lead to significant differences between the responses to mixtures and those to single component stimuli. On average, the response latency of olfactory receptor neurons at low stimulus concentrations is reduced and the response patterns become less variable across concentrations as the number of odour components in the stimulus increases. These effects are preserved in the projection neurons. Our results suggest that the early olfactory system of insects may be particularly efficient in processing mixtures, which corresponds well to the observation that chemical signalling in nature predominantly involves mixtures.
External mentoring for new teachers: mentor learning for a change agenda
Authors: Daly Caroline , Milton Emmajane 
Published: July 2017

PurposeThe purpose of this paper is to report on a qualitative study of the learning and development of 70 external mentors during the first year of their deployment to support early career teachers’ professional learning as part of a national initiative aimed at school improvement in Wales.Design/methodology/approachThe study adopted a narrative methodology that elicited accounts of external mentors’ learning experiences that were captured as textual data and analysed using an inductive approach to identify: first, the manifest themes that appeared at declarative level, and second, the latent (sub-textual) themes of external mentor learning and development.FindingsFour key themes emerged that indicate the complexity of transition to the role of external mentor in high-stakes contexts. From these, eight theoretically-informed principles were derived which support mentors to embrace uncertainty as essential to their learning and development, and to harness the potential they bring as boundary-crossers to support the development of new teachers.Research limitations/implicationsThe study investigated the first year of a three-year programme and worked with one form of qualitative data collection. The research results may lack generalisability and a longitudinal study is necessary to further explore the validity of the findings.Practical implicationsThe eight principles provide a foundation for mentor development programmes that can support ambitious goals for mentoring early career teachers.Originality/valueThe study addresses the under-researched area of the learning and development of external mentors at a national scale.