bluuebunny/crossref_metadata_2025_split huggingface dataset:
National libraries and regional cooperations: a framework for ECO national libraries
Authors: Najafqolinejad Azam , Hassanzadeh Mohammad 
Published: March 2016

Purpose
– The purpose of this paper is to study the cultural integration, the role of national libraries in regional and international cooperation, Economic Cooperation Organization (ECO) national libraries’ barriers of cooperation and drivers of their cooperation and to propose a framework (conceptual and operational) for their cooperation.

Design/methodology/approach
– Data collection tool of this survey was a researcher-made questionnaire, sent to 30 individuals and experts involved in cooperation of ECO National Libraries from eight institutions. The reliability of the questionnaire was calculated using Cronbach’s alpha. It was 0.91. In this study, for awareness of activities between ECO national libraries and extraction of drivers, some documents were studied, and preliminary data were collected by informal interviews with meeting stakeholders and participants.

Findings
– The lack of stability in management positions was one of the major barriers in cooperation of the ECO national libraries. Other major obstacles in this context were lack of continuous communication, lack of common protocols and standards, lack of planning, lack of a central coordinating organization, bureaucracy, etc. Geographical proximity, common history and heritage, common resources, Islamic and cultural factors, importance of information and knowledge, requirements of the international system and political and security requirements were considered as drivers. An information centre was proposed for their active cooperation. Iran is better to host the information centre.

Originality/value
– National libraries as the scientific and cultural memory of nations and heirs of written heritage should cooperate and share their valuable scientific and cultural heritage to the future generations.
An intelligent tracking system based on internet of things for the cold chain
Authors: Luo Heng , Zhu Minjie , Ye Sengang , Hou Hanping , Chen Yong , Bulysheva Larissa 
Published: March 2016

Purpose
– Monitoring the real-time temperature, humidity, and physical position status of goods is vital in the cold chain. Diverse logistics technologies and systems have been adopted in the cold chain for monitoring perishable goods. However, these technologies and systems are independent from each other. Data and information in them are not integrated so that information control is not effective. The paper aims to discuss these issues.

Design/methodology/approach
– By integrating Internet of Things and tracking technologies, this paper proposes an intelligent tracking system, which is designed to achieve effective and fast live monitoring of goods in the cold chain at the lowest cost and with the largest network capacity and simplest protocols.

Findings
– Structure and information platform design mechanism are introduced. The key part of this system is a wireless sensor network built on Zigbee. Wireless sensors located in cold storages or refrigerated trucks are able to collect and transmit live data quickly and efficiently.

Originality/value
– Users of the proposed system can easily monitor goods transported in cold chains. In addition, the system assigns specific servers to save historical data for inquiries.
Developing organisational capabilities to support agility in humanitarian logistics
Authors: L'Hermitte Cécile , Tatham Peter , Bowles Marcus , Brooks Ben 
Published: March 2016

Purpose– The purpose of this paper is to explore the underlying strategic mechanisms of agility in a humanitarian logistics context. Based on the research conducted in business disciplines, the paper empirically examines a set of four strategic dimensions (being purposeful, being action-focused, being collaborative, and being learning-oriented) and identifies an emergent relationship between these capabilities and agile humanitarian logistics operations.Design/methodology/approach– Leadership and management actions perceived to support the four capabilities were identified and used as a basis to complete the exploratory research. Specifically, a case study with the United Nations World Food Programme (WFP) was undertaken and, in this context, a qualitative analysis of 29 face-to-face interviews with humanitarian logistics experts working for WFP was conducted.Findings– The research corroborates the relevance of the four strategic-level capabilities to the humanitarian logistics context and confirms that these capabilities play a role in the development of agility in humanitarian operations. The work also identifies a set of key strategic decision-making areas that relate to the building of agility.Research limitations/implications– Additional research is needed to further investigate and measure the strategic-level capabilities and to quantify their impact on operational agility. Further research should also be undertaken to extend this study to a wider range of humanitarian organisations.Originality/value– This paper is the first empirical research that takes a strategic approach to the concept of agility in humanitarian logistics. It highlights that the leaders and managers of humanitarian organisations have a significant role to play in the building of an agile system.
Quantifying communication effects in disaster response logistics
Authors: Diedrichs Danilo R. , Phelps Kaile , Isihara Paul A. 
Published: March 2016

Purpose
– Complementing the importance of adequate relief supplies and transportation capacity in the first two weeks of post-disaster logistics, efficient communication, information sharing, and informed decision making play a crucial yet often underestimated role in reducing wasted material resources and loss of human life. The purpose of this paper is to provide a method of quantifying these effects.

Design/methodology/approach
– A mathematical discrete dynamical system is used to model transportation of different commodities from multiple relief suppliers to disaster sites across a network of limited capacity. The physical network is overlaid with the communication network to model information delays and communication breakdowns between agents. The cost in human lives and the monetary cost are measured separately.

Findings
– Simulations results highlight quantitatively how communication deficiencies and indiscriminate shipping of resources result in material convergence and shortage of urgent supplies observed in actual emergencies.

Originality/value
– The model provides an example of a simple, objective, quantitative tool for decision making and training volunteer managers in the importance of a smart response protocol.
Systemic barriers and enablers in humanitarian technology transfer
Authors: Santos Ana Laura R. , Wauben Linda S.G.L. , Goossens Richard , Brezet Han 
Published: March 2016

Purpose
– The purpose of this paper is to collect information about barriers and enablers experienced by international experts when transferring medical equipment to countries affected by humanitarian emergencies and to discuss the suitability of the principles of “openness”, “interconnections” and “non-linearity” of systems to understand the nature of the barriers and enablers as described by the international experts.

Design/methodology/approach
– In this study, six semi-structured interviews were conducted with experts from humanitarian organizations. The interviews were based on a simplified model of the transfer of medical equipment adapted from supply chain literature. The model ensured that all the process steps undertaken by humanitarian organizations were considered. Afterwards, the interviews were transcribed and structurally analysed to derive barriers and enablers. Finally, the results were described in light of three theoretical principles of systems thinking.

Findings
– In total, 14 types of barriers and 12 types of enablers were uncovered that illustrate the complexity of transferring medical equipment in humanitarian emergencies. The paper concludes with a proposal for future research to investigate if, and how, an approach guided by systems thinking could help to create a designated space for the formulation of original, synergetic solutions that address the identified barriers.

Originality/value
– This study is the first to explore the specific logistic challenges implicit in the transfer of medical equipment in humanitarian emergencies with a lifecycle perspective. Furthermore, the concept of systems thinking is rather novel in the field of transfer of medical technology.
An explanation of economic impact: why positive impacts can exist for smaller sports
Authors: Agha Nola , Rascher Daniel A. 
Published: March 2016

Purpose– The purpose of this paper is to understand why some sports show a positive economic impact and other sports do not, and to identify a common set of explanatory factors explaining the differences.Design/methodology/approach– This explanatory research reviews the economic impact literature to identify the underlying conditions that would theoretically allow any sport, large or small, to generate positive economic effects.Findings– Nine conditions are identified that, when present, could allow a community to experience a positive economic impact from a team or stadium. These are then used to explain the discrepancy in known empirical outcomes in major and minor league baseball (MiLB). It appears as if major league teams are more likely to violate the conditions than minor league teams. This research finds theoretical support for previous suggestions that smaller teams and events may be beneficial to local economies. In doing so, it also explains previous empirical results that found some MiLB classifications are associated with positive gains in per capita income.Practical implications– Stakeholders can use the nine conditions to understand expected economic impact of their relevant sports. This research provides a comprehensive guide to understanding when economic impact can be positive.Social implications– This research helps explain some of the existing controversy regarding economic impact analysis.Originality/value– It is the first research to help provide a pre-set of conditions that can help predict whether positive economic impact will occur for specific sports teams or stadium projects.
Comparisons of the utility of researcher‐defined and participant‐defined successful ageing
Authors: Brown Lynsey J. , Bond Malcolm J. 
Published: March 2016

AimTo investigate the impact of different approaches for measuring ‘successful ageing’, four alternative researcher and participant definitions were compared, including a novel measure informed by cluster analysis. Rates of successful ageing were explored, as were their relative associations with age and measures of successful adaptation, to assess construct validity.MethodParticipants, aged over 65, were recruited from community‐based organisations. Questionnaires (assessing successful ageing, lifestyle activities and selective optimisation with compensation) were completed by 317 individuals.ResultsSuccessful ageing ranged from 11.4% to 87.4%, with higher rates evident from participant definitions. Though dependent upon the definition, successful agers were typically younger, reported greater engagement with lifestyle activities and more frequent optimisation.ConclusionsWhile the current study suggested an improved classification algorithm using a common research definition, future research should explore how subjective and objective aspects of successful ageing may be combined to derive a measure relevant to policy and practice.
Effect of omalizumab on angioedema in H1‐antihistamine‐resistant chronic spontaneous urticaria patients: results from X‐ACT, a randomized controlled trial
Authors: Staubach P. , Metz M. , Chapman‐Rothe N. , Sieder C. , Bräutigam M. , Canvin J. , Maurer M. 
Published: March 2016

AbstractBackgroundChronic spontaneous urticaria (CSU) severely impacts quality of life (QoL), especially in patients with wheals and angioedema. Omalizumab is approved as add‐on therapy for CSU patients; however, its effect on patients who are double‐positive for wheals and angioedema has not been systematically studied.ObjectiveThe primary objective was to evaluate the efficacy of omalizumab vs placebo at week 28 using the Chronic Urticaria Quality of Life (CU‐Q2oL) questionnaire. Number of angioedema‐burdened days, time interval between successive angioedema episodes, disease activity, angioedema‐specific and overall QoL impairment were secondary objectives.MethodsX‐ACT was a phase III, randomized, double‐blind study conducted in 24 centres (Germany), which selectively included CSU patients with angioedema and wheals. Patients were randomized (1 : 1) to omalizumab 300 mg or placebo (every 4 weeks up to week 24) (ClinicalTrials.gov number: NCT01723072).ResultsOf the 91 patients randomized to omalizumab (n = 44) or placebo (n = 47) at baseline, 68 completed the 28‐week treatment phase (omalizumab, 35; placebo, 33). Omalizumab was superior to placebo in improving CU‐Q2oL scores at week 28 (P < 0.001). There was a threefold improvement in angioedema‐burdened days/week with omalizumab (0.3) vs placebo (1.1). The median time to first recurrence of angioedema was 57–63 days with omalizumab and <5 days with placebo. Omalizumab significantly improved angioedema‐specific QoL (P < 0.001). The adverse events reported are in line with the established safety profile of omalizumab.ConclusionOmalizumab was an effective treatment option for patients with moderate‐to‐severe CSU symptoms and angioedema unresponsive to high doses of antihistamine treatment.
Value of posterior keratometry in the assessment of surgically induced astigmatic change in cataract surgery
Authors: Klijn Stijn , van der Sommen Charlotte M. , Sicam Victor Arni D. P. , Reus Nicolaas J. 
Published: March 2016

AbstractPurposeTo investigate the value of posterior keratometry in the assessment of surgically induced astigmatic change (AC) in cataract surgery, with particular emphasis on the influence of test–retest variability.MethodsSeventy‐seven eyes of 77 cataract patients scheduled for routine cataract surgery were enrolled. All patients received a 2.2‐mm self‐sealing scleral incision (n = 24), single‐plane clear corneal incision (SPCCI; n = 29) or biplanar clear corneal incision (BPCCI; n = 24). Measurements of anterior and posterior corneal astigmatism were performed with a rotating Scheimpflug camera (Pentacam HR) preoperatively and postoperatively. Two repeated readings were taken preoperatively to assess the role of the test–retest effect. Astigmatic change (AC) was analysed according to the polar value method.ResultsOn the anterior corneal surface, SPCCIs and BPCCIs caused a statistically significant mean flattening of the incisional meridian of 0.37 and 0.27 dioptres (D), respectively. Scleral incisions on average did not cause AC, although steepening, flattening or torque beyond the test–retest effect was observed in individual cases. On the posterior surface, mean power changes in the incisional meridian were below 0.1 D for all incisions, and these changes were of the same order of magnitude as the test–retest effect.ConclusionSurgically induced AC of the posterior corneal surface after cataract surgery is of negligible clinical relevance. Moreover, it is of the same order of magnitude as the test–retest variability of the measurement device and therefore cannot (yet) be reliably assessed.
BRAF mutations in conjunctival melanoma: investigation of incidence, clinicopathological features, prognosis and paired premalignant lesions
Authors: Larsen Ann‐Cathrine , Dahl Christina , Dahmcke Christina M. , Lade‐Keller Johanne , Siersma Volkert D. , Toft Peter B. , Coupland Sarah E. , Prause Jan U. , Guldberg Per , Heegaard Steffen 
Published: March 2016

AbstractPurposeTo investigate incidence, clinicopathological features and prognosis of BRAF‐mutated conjunctival melanoma in Denmark. Furthermore, to determine BRAF mutations in paired premalignant lesions and evaluate immunohistochemical BRAF V600E oncoprotein detection.MethodsData from 139 patients with conjunctival melanoma (1960–2012) were collected. Archived conjunctival melanoma samples and premalignant lesions were analysed for BRAF mutations using droplet digital polymerase chain reaction (PCR). Results were associated with clinicopathological features and compared with BRAF V600E oncoprotein stainings.ResultsThe overall incidence of conjunctival melanoma (0.5 cases/1 000 000/year) increased during the study period with 0.13 cases/1 000 000/10 years. The increase comprised a higher proportion of patients aged >65 years, epibulbar tumours and tumours developed from a primary acquired melanosis with atypia. BRAF mutations were identified in 39 of 111 (35%) cases. The rate ratio of BRAF‐mutated versus BRAF‐wild‐type melanoma did not change over time. BRAF mutations were associated with T1 stage (p = 0.007), young age (p = 0.001), male gender (p = 0.02), sun‐exposed location (p = 0.01), mixed/non‐pigmented tumour colour (p = 0.02) and nevus origin (p = 0.005), but did not associate with prognosis. BRAF status in conjunctival melanoma and paired premalignant lesions corresponded in 19 of 20 cases. Immunohistochemistry detected BRAF V600E mutations with a sensitivity of 0.94 and a specificity of 1.00 in newer conjunctival melanoma samples (2000–2012, n = 47).ConclusionThe incidence of conjunctival melanoma increased in Denmark over 50 years. The proportion of BRAF‐mutated conjunctival melanoma was constant. BRAF mutations were identified as early events in conjunctival melanoma, associated with a distinct clinicopathological profile, similar to BRAF‐mutated cutaneous melanoma. Immunohistochemical detection of BRAF can be used to assess BRAF V600E mutations.
The prognostic value of retinal vessel analysis in primary open‐angle glaucoma
Authors: Waldmann Nicolas Philipp , Kochkorov Asan , Polunina Anna , Orgül Selim , Gugleta Konstantin 
Published: March 2016

AbstractPurposeTo analyse a prognostic value of initial retinal vessel flicker response for the 3‐year development of functional (visual field) and morphological (nerve fibre layer thickness) damage progression in primary open‐angle glaucoma patients.Patients and methodsInitially, 70 patients were recruited, and flicker response was measured by standardized procedure with the retinal vessel analyser (RVA). Ocular coherence tomography of retinal nerve fibre layer (OCT RNFL) and a visual field testing were performed at beginning and every 6 months for 3 years; 56 patients completed the study.ResultsNo correlation was found between the progression of visual field (VF) mean defect and retinal nerve fibre layer (RNFL) thinning over 3 years on one and the maximal flicker reaction in arteries and veins on the other side (all p > 0.1). However, the calculated difference of examined parameters in the superior versus inferior retinal halves correlated significantly between the RNFL thinning and the initial maximal flicker response for arteries (p = 0.01) and veins (p = 0.003).ConclusionThis longitudinal study did not find a general correlation between initial retinal vessel response to flicker light and the glaucoma damage progression measured by OCT and VF, hence limiting the relevance of the RVA device as a predictor of future glaucomatous damage.
What made you wait so long? Delays in presentation of retinal detachment: knowledge is related to an attached macula
Authors: Eijk Eva S. V. , Busschbach Jan J. V. , Timman Reinier , Monteban Helma C. , Vissers Jan M. H. , van Meurs Jan C. 
Published: March 2016

AbstractPurposeIn rhegmatogenous retinal detachment, the time between first symptoms and reattachment surgery is critical to prevent macular detachment. We explored which determinants discriminate between ‘macula‐ON’ and ‘macula‐OFF’ retinal detachments to improve timely treatment.MethodsEight‐hundred patients with rhegmatogenous retinal detachment admitted for surgery at the Rotterdam Eye Hospital in the Netherlands were eligible to complete a questionnaire to explore the following determinants: (i) patient's delay and doctor's delay; (ii) patient‐reported causes for delay; (iii) symptoms as early warning signals; (iv) patient's prior knowledge about retinal detachment; and (v) trait anxiety.ResultsFive hundred and twenty‐one questionnaires (65%) were analysed. Median interval between first symptoms and surgery was 14 days. Macula‐ON/OFF ratio was 46/54. Patient's delay in macula‐ON patients (median 3 days) was shorter than in macula‐OFF (5 days, p = 0.026). No difference was found in doctor's delay except for ‘waiting time for surgery’: macula‐ON patients were operated on faster (median 1 day) than macula‐OFF (median 5 days, p < 0.001). Macula‐ON patients more often attributed symptoms to retinal problems. Except floaters, no symptoms were determined as early warning signals for macula‐ON. Macula‐ON patients more often reported knowing that prognosis would be worse when treated later, even when controlled for previous experience with retinal detachment.ConclusionMacula‐ON patients seem to self‐refer faster to a healthcare provider, seem more sensitive to floaters and seem more informed. This suggests that increasing awareness, especially about floaters, might increase the proportion of patients with macula still on at the moment of referral to the ophthalmologist.
A Regional Drug and Therapeutics Committee‐led Intervention to Reduce the Hospital Costs of Expensive HIV Drugs
Authors: Mikkelsen Camilla Munk , Andersen Stig Ejdrup 
Published: March 2016

AbstractIn 2009, the regional Drug and Therapeutics Committee (DTC) began a series of meetings with lead specialists in infectious diseases. The role of the DTC was to engage clinicians and ensure commitment to prescribing the least expensive drugs among the clinically equivalent HAARTs (highly active antiretroviral therapy). DTC also led implementation of a national guideline. This study analyses the impact of this process on HAART consumption and expenditure. The HAART consumption and expenditure (2009–2013) was compared to forecasts produced by exponential smoothing (2004–2009). Abrupt switches between drug regimens coincided with the DTC‐led meetings. Overall, HAART consumption rose 16%, while price per defined daily dose (DDD) fell 11% and the 2013 expenditure decreased 23%. The consumption of drugs addressed by the guideline rose 48%. Still, the 2013 expenditure was 41.5 million DKK (5.5 million €) (27%) lower than expected, reflecting a fall in price per DDD that coincided with the intervention. The consumption of drugs not addressed by the guideline rose 8.3%, while price per DDD fell 8.5% and the 2013 expenditure was 26.8 million DKK (3.6 million €) (19%) lower than expected. Despite a steadily increasing consumption, significant cost savings followed this DTC‐led intervention. This multifaceted approach might be applicable to changing the prescribing of other expensive drug classes.