bluuebunny/crossref_metadata_2025_split huggingface dataset:
DWI-ASPECTS (Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores) and DWI-FLAIR (Diffusion-Weighted Imaging–Fluid Attenuated Inversion Recovery) Mismatch in Thrombectomy Candidates
Authors: Fahed Robert , Lecler Augustin , Sabben Candice , Khoury Naim , Ducroux Célina , Chalumeau Vanessa , Botta Daniele , Kalsoum Erwah , Boisseau William , Duron Loïc , Cabral Dominique , Koskas Patricia , Benaïssa Azzedine , Koulakian Hasmik , Obadia Michael , Maïer Benjamin , Weisenburger-Lile David , Lapergue Bertrand , Wang Adrien , Redjem Hocine , Ciccio Gabriele , Smajda Stanislas , Desilles Jean-Philippe , Mazighi Mikaël , Ben Maacha Malek , Akkari Inès , Zuber Kevin , Blanc Raphaël , Raymond Jean , Piotin Michel 
Published: November 2017

Background and Purpose—
We aimed to study the intrarater and interrater agreement of clinicians attributing DWI-ASPECTS (Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores) and DWI-FLAIR (Diffusion-Weighted Imaging–Fluid Attenuated Inversion Recovery) mismatch in patients with acute ischemic stroke referred for mechanical thrombectomy.

Methods—
Eighteen raters independently scored anonymized magnetic resonance imaging scans of 30 participants from a multicentre thrombectomy trial, in 2 different reading sessions. Agreement was measured using Fleiss κ and Cohen κ statistics.

Results—
Interrater agreement for DWI-ASPECTS was slight (κ=0.17 [0.14–0.21]). Four raters (22.2%) had a substantial (or higher) intrarater agreement. Dichotomization of the DWI-ASPECTS (0–5 versus 6–10 or 0–6 versus 7–10) increased the interrater agreement to a substantial level (κ=0.62 [0.48–0.75] and 0.68 [0.55–0.79], respectively) and more raters reached a substantial (or higher) intrarater agreement (17/18 raters [94.4%]). Interrater agreement for DWI-FLAIR mismatch was moderate (κ=0.43 [0.33–0.57]); 11 raters (61.1%) reached a substantial (or higher) intrarater agreement.

Conclusions—
Agreement between clinicians assessing DWI-ASPECTS and DWI-FLAIR mismatch may not be sufficient to make repeatable clinical decisions in mechanical thrombectomy. The dichotomization of the DWI-ASPECTS (0–5 versus 0–6 or 0–6 versus 7–10) improved interrater and intrarater agreement, however, its relevance for patients selection for mechanical thrombectomy needs to be validated in a randomized trial.
Habitat heterogeneity as a local and regional-scale driver of primate assemblage structure in northernmost Brazilian Amazonia
Authors: Gadelha José Ramon , de Andrade Melo Éverton Renan , da Silva Maria Nazaré Domingos , da Silva Júnior Antonio Paulo , Filgueiras Bruno Karol Cordeiro , Mendes Pontes Antonio Rossano 
Published: November 2017

We performed line transect surveys in two fishbone human settlements (defined as clearings cut through forests in a fishbone pattern, extending along secondary roads from a main road) in different vegetation types, as well as in one protected area. A total of 410 sightings of eight primate species were recorded in the three study areas. The mean total primate abundance was 3.28 groups/10 km walked, and there were significant differences between areas with different plant physiognomies. The abundance of the larger primate species Alouatta macconnelli and Ateles paniscus (Atelidae) was higher in the dense ombrophilous forests of the Entre Rios human settlement, whereas those of all the other species were higher in the forest mosaics of the Novo Paraíso human settlement and Viruá National Park. The habitat generalist Sapajus apella presented the highest abundances in all the areas. No significant differences were detected in relative biomass between study areas. Additionally, no significant differences were detected in the overall abundances or relative biomasses of the hunted species (Sapajus apella, Alouatta macconnelli, Ateles paniscus, and Chiropotes chiropotes) between study areas. Human impact has been recognized as shaping primate assemblages. However, in this study, primates were not part of the dietary repertoire of the non-Amazonian immigrants inhabiting the fishbone human settlements. Thus, although the primate assemblages varied considerably at the regional and local level, they were shaped by habitat heterogeneity, which allowed the competing species to coexist through habitat segregation.
Population structure and morphometric variation in the sand-bubbler crab Scopimera crabricauda (Brachyura: Dotillidae)
Authors: Sharifian Sana , Malekzadeh Vahid , Kamrani Ehsan , Safaie Mohsen 
Published: November 2017

In the present study, population ecology and relationships between various morphometric characters of the sand-bubbler crab Scopimera crabricauda from the Persian Gulf (Iran) were studied. Crabs were collected monthly by excavating nine quadrats in high-density areas of open burrows at low, mid and high intertidal levels during spring low tides for one year. A total of 534 crabs was collected, of which 70% were males (and 30% females). Mean carapace width and total weight in both sexes showed significant differences. Crabs with a carapace width ranging from 5 to 7 mm were the dominant crabs in the population. The highest numbers of crabs were found in the higher intertidal area. The mean size of crabs decreased towards the sea. The aggregation of small crabs was found towards sea in female crabs. Juveniles were abundantly found from January to March whereas the sub-adults and adults were mostly found from April to January. The carapace length to carapace width relationship differed between males and females, as did the carapace width and carapace length to total weight relationships. Finally, the relationship between carapace width and weight for both sexes showed that the growth of this species is allometric.
A Footnote to the Composition History of Maqālāt al-islāmiyyīn: The Internal Parallels in al-Ashʿarī’s Material on the Shia
Authors: Weaver James 
Published: November 2017

AbstractAbū l-Ḥasan al-Ashʿarī’s (d. 324/935-6)Maqālāt al-islāmiyyīn wa-khtilāf al-muṣallīnis our largest single source of information on earlykalām. Since the mid-twentieth century, scholars have proposed various composition histories for the work, all of which involve the claim that the presentMaqālātwas not originally conceived as a single, integral text. These composition histories are intended to account for formal features, such as the presentMaqālāt’s structural unevenness and large amounts of internal repetition, and for certain features of content, such as the apparent commitment, or absence thereof, of its different parts to the theological positions of the Traditionalists. The chronology of its composition also has a bearing on the nature of its relationship to the slightly earlierMaqālāt firaq ahl al-qiblaof Abū l-Qāsim al-Balkhī al-Kaʿbī (d. 319/931). This article, based on a detailed analysis of the internal parallels within al-Ashʿarī’s material on the Shia, examines some previously overlooked evidence relevant to theMaqālāt’s composition history.
The Environment Canada Pan and Parapan American Science Showcase Project
Authors: Joe P. , Belair S. , Bernier N.B. , Bouchet V. , Brook J. R. , Brunet D. , Burrows W. , Charland J.-P. , Dehghan A. , Driedger N. , Duhaime C. , Evans G. , Filion A.-B. , Frenette R. , de Grandpré J. , Gultepe I. , Henderson D. , Herdt A. , Hilker N. , Huang L. , Hung E. , Isaac G. , Jeong C.-H. , Johnston D. , Klaassen J. , Leroyer S. , Lin H. , MacDonald M. , MacPhee J. , Mariani Z. , Munoz T. , Reid J. , Robichaud A. , Rochon Y. , Shairsingh K. , Sills D. , Spacek L. , Stroud C. , Su Y. , Taylor N. , Vanos J. , Voogt J. , Wang J. M. , Wiechers T. , Wren S. , Yang H. , Yip T. 
Published: November 2017

AbstractThe Pan and Parapan American Games (PA15) are the third largest sporting event in the world and were held in Toronto in the summer of 2015 (10–26 July and 7–15 August). This was used as an opportunity to coordinate and showcase existing innovative research and development activities related to weather, air quality (AQ), and health at Environment and Climate Change Canada. New observational technologies included weather stations based on compact sensors that were augmented with black globe thermometers, two Doppler lidars, two wave buoys, a 3D lightning mapping array, two new AQ stations, and low-cost AQ and ultraviolet sensors. These were supplemented by observations from other agencies, four mobile vehicles, two mobile AQ laboratories, and two supersites with enhanced vertical profiling. High-resolution modeling for weather (250 m and 1 km), AQ (2.5 km), lake circulation (2 km), and wave models (250-m, 1-km, and 2.5-km ensembles) were run. The focus of the science, which guided the design of the observation network, was to characterize and investigate the lake breeze, which affects thunderstorm initiation, air pollutant transport, and heat stress. Experimental forecasts and nowcasts were provided by research support desks. Web portals provided access to the experimental products for other government departments, public health authorities, and PA15 decision-makers. The data have been released through the government of Canada’s Open Data Portal and as a World Meteorological Organization’s Global Atmospheric Watch Urban Research Meteorology and Environment dataset.
Congenital Heart Defects in Nigerian Children: Preliminary Data From the National Pediatric Cardiac Registry
Authors: Ekure Ekanem N. , Bode-Thomas Fidelia , Sadoh Wilson E. , Orogade Adeola A. , Otaigbe Barbara E. , Ujunwa Fortune , Sani Usman M. , Asani Mustafa , Animasahun Adeola B. , Ogunkunle Oluwatoyin O. ,   Nigerian Pediatric Cardiology Study Group
Published: November 2017

Background: Congenital heart defects (CHDs) are common birth defects with significant impact on morbidity and mortality. We aimed to compare regional patterns of CHDs in Nigeria using a registry-based approach. Methods: Children with echocardiography-confirmed CHDs at 17 medical centers across the country were enrolled in a pilot National Pediatric Cardiac Registry from January to December 2014. Results: A total of 1,296 children (52.9% male; median age 0.9 years) with CHDs were enrolled. Patients enrolled in Northern Nigeria constituted 34.6% of the study population and were older compared to those enrolled from Southern Nigeria (2.9 ± 3.6 vs 2.4 ± 3.5 years; P = .02). Ventricular septal defects were significantly more prevalent in the North (37.4%) compared with the South (18.5%; P < .0001), while severe CHDs were more prevalent in the South ( P = .004). Of the 208 (16.0%) children who received corrective cardiac intervention, only 43 (20.7%) of them had the intervention done in country. More patients in the South received intervention compared to the North (19.02% vs 10.5%; P < .0001). Conclusion: This is the first prospective, registry-based, multicenter study of CHDs in Nigerian children. We demonstrate important differences between the Northern and the Southern geographical regions of the country in terms of age at diagnosis, type, and severity of lesion as well as access to cardiac surgery. The findings demonstrate the utility of a national CHDs registry for understanding clinical epidemiology of CHDs in low- and middle-income countries and its potential to serve as a basis for research and planning.
Hubungan perilaku Keluarga Sadar Gizi (KADARZI) dan Perilaku Hidup Bersih Sehat (PHBS) pada tatanan rumah tangga dengan status gizi balita usia 24-59 bulan
Authors: Hartono Hartono , Widjanarko Bagoes , EM Mexitalia Setiawati 
Published: November 2017

Background: The prevalence of malnutrition among toddler in Kotabaru district was still high at 20,86 %. The family implemented Kadarzi was 56,24 % while the family who implemented PHBS was 42,48 %, this prevalence was still low. Objective: The purpose was analyzed the relationship between Kadarzi and PHBS behavior of households with nutritional status of toddler of 24-59 months. Methods: The design was cross sectional study conducted in Puskesmas Dirgahayu. Subjects were children aged 24-59 months who lived in Puskesmas Dirgahayu area, who coverese with inclusion and exclusion criteria twose, subjects are 90 respondens. Sampling technical by simple random sampling. Analysis tests used chi square test and logistic regression with 95% confidence level. Questionnaire was used as tools research, energy and protein intake was measured by recall method.Results: The results showed 27,8 % children was categorized as malnutrition status, 72,2 % family implemented Kadarzi and 70,0 % Kadarzi behave uncategorised healthy home. Analysis of the data showed no significant relationship between Kadarzi behavior with nutritional status (p=0,000, OR=31,13). There was a significant relationship between clean and healthy behavior with nutritional status (p=0,000, OR=22,56). Analysis of multiple logistic regression test obtained dominant factor associated with nutritional status is Kadarzi behavior (p=0,000, OR=0,08). Conclusion: There was a significant relationship between Kadarzi and PHBS behavior of households with nutritional status of toddler 24-59 months.
Design and Development of Detector Simulator for Total Ionized Dose and ground checkout system of radiation monitoring instrument
Authors: Mahant Keyur , Bhatt Chintan 
Published: November 2017

Abstract
This Paper describes the simulator development for the Total Ionizing Dose (TID) measurement of radiation monitoring instrument. The TID Detector (UDOS001-micro dosimeter) is a compact hybrid microcircuit which directly measures Total Ionizing Dose absorbed by an internal silicon test mass. The developed detector simulator, simulates the equivalent Total Ionized Dose absorbed from the space radiation and Ground checkout simulator receive the data from Radiation monitoring Instrument through UART and process it for the functional verification of the Radiation monitoring Instrument, which is discussed in the paper.
Ceramic Matrix Composite Turbine Vane Thermal Simulation Test and Evaluation
Authors: Huo Shiyu , Yan Qun , Gao Xiang , You Yu 
Published: November 2017

Abstract
Ceramic Matrix Composites (CMCs) are primary candidates for advanced gas turbine engine application that require intense high temperature tests and validations. Before CMCs used in engine hot sections, a lot of tests need to be done, especially thermal test. A thermal test rig has been set up to simulate the engine turbine thermal environment. Propane gas is used to simulate the practical aviation fuel and compressed air with flow regulator is used as cooling media. The capabilities and limitations of the test facility have been calibrated and discussed in this paper. A CMC turbine vane with internal cooling path was tested on this burning rig. The results showed that the CMC vane could withstand the 1200 ℃ thermal cycling test but the coating was disappeared. It has been proved that such test rig and method could simulate the thermal boundary conditions of turbine vanes and blades.
Impact of Deposition Rate on the Structural and Magnetic Properties of Sputtered Ni/Cu Multilayer Thin Films
Authors: Karpuz Ali , Colmekci Salih , Kockar Hakan , Kuru Hilal , Uckun Mehmet 
Published: November 2017

Abstract
The structural and corresponding magnetic properties of Ni/Cu films sputtered at low and high deposition rates were investigated as there is a limited number of related studies in this field. 5[Ni(10 nm)/Cu(30 nm)] multilayer thin films were deposited using two DC sputtering sources at low (0.02 nm/s) and high (0.10 nm/s) deposition rates of Ni layers. A face centered cubic phase was detected for both films. The surface of the film sputtered at the low deposition rate has a lot of micro-grains distributed uniformly and with sizes from 0.1 to 0.4 μm. Also, it has a vertical acicular morphology. At high deposition rate, the number of micro-grains considerably decreased, and some of their sizes increased up to 1 μm. The surface of the Ni/Cu multilayer deposited at the low rate has a relatively more grainy and rugged structure, whereas the surface of the film deposited at the high rate has a relatively larger lateral size of surface grains with a relatively fine morphology. Saturation magnetisation, M
s, values were 90 and 138 emu/cm3 for deposition rates of 0.02 and 0.10 nm/s, respectively. Remanence, M
r, values were also found to be 48 and 71 emu/cm3 for the low and high deposition rates, respectively. The coercivity, H
c, values were 46 and 65 Oe for the low and high Ni deposition rates, respectively. The changes in the film surfaces provoked the changes in the H
c values. The M
s, M
r, and H
c values of the 5[Ni(10 nm)/Cu(30 nm)] films can be adjusted considering the surface morphologies and film contents caused by the different Ni deposition rates.
Pregnancy outcomes are not altered by variation in thyroid function within the normal range in women free of thyroid disease
Authors: Veltri Flora , Kleynen Pierre , Grabczan Lidia , Salajan Alexandra , Rozenberg Serge , Pepersack Thierry , Poppe Kris 
Published: November 2017

ObjectiveIn the recently revised guidelines on the management of thyroid dysfunction during pregnancy, treatment with thyroid hormone (LT4) is not recommended in women without thyroid autoimmunity (TAI) and TSH levels in the range 2.5–4.0 mIU/L, and in a recent study in that particular group of pregnant women, more complications were observed when a treatment with LT4 was given. The objective of the study was therefore to investigate whether variation in thyroid function within the normal (non-pregnant) range in women free of thyroid disease was associated with altered pregnancy outcomes?DesignCross-sectional data analysis of 1321 pregnant women nested within an ongoing prospective collection of pregnant women’s data in a single centre in Brussels, Belgium.MethodsThyroid peroxidase antibodies (TPO-abs), thyroid-stimulating hormone (TSH), free T4 (FT4) and ferritin levels were measured and baseline characteristics were recorded. Women taking LT4, with TAI and thyroid function outside the normal non-pregnant range were excluded. Pregnancy outcomes and baseline characteristics were correlated with all TSH and FT4 levels within the normal range and compared between two groups (TSH cut-off < and ≥2.5 mIU/L).ResultsTobacco use was associated with higher serum TSH levels (OR: 1.38; CI 95%: 1.08–1.74);P = 0.009. FT4 levels were inversely correlated with age and BMI (rho = −0.096 and −0.089;P < 0.001 and 0.001 respectively) and positively correlated with ferritin levels (rho = 0.097;P < 0.001). Postpartum haemorrhage (>500 mL) was inversely associated with serum FT4 levels (OR: 0.35; CI 95%: 0.13–0.96);P = 0.040. Also 10% of women free of thyroid disease had serum TSH levels ≥2.5 mIU/L.ConclusionsVariation in thyroid function during the first trimester within the normal (non-pregnant) range in women free of thyroid disease was not associated with altered pregnancy outcomes. These results add evidence to the recommendation against LT4 treatment in pregnant women with high normal TSH levels and without TPO antibodies.
Tissue-Specific Gene Inactivation inXenopus laevis: Knockout oflhx1in the Kidney with CRISPR/Cas9
Authors: DeLay Bridget D , Corkins Mark E , Hanania Hannah L , Salanga Matthew , Deng Jian Min , Sudou Norihiro , Taira Masanori , Horb Marko E , Miller Rachel K 
Published: November 2017

AbstractXenopus laevis is a classic developmental model, but its allotetraploid genome has limited our ability to perform genetic manipulations. The advance of...Studying genes involved in organogenesis is often difficult because many of these genes are also essential for early development. The allotetraploid frog, Xenopus laevis, is commonly used to study developmental processes, but because of the presence of two homeologs for many genes, it has been difficult to use as a genetic model. Few studies have successfully used CRISPR in amphibians, and currently there is no tissue-targeted knockout strategy described in Xenopus. The goal of this study is to determine whether CRISPR/Cas9-mediated gene knockout can be targeted to the Xenopus kidney without perturbing essential early gene function. We demonstrate that targeting CRISPR gene editing to the kidney and the eye of F0 embryos is feasible. Our study shows that knockout of both homeologs of lhx1 results in the disruption of kidney development and function but does not lead to early developmental defects. Therefore, targeting of CRISPR to the kidney may not be necessary to bypass the early developmental defects reported upon disruption of Lhx1 protein expression or function by morpholinos, antisense RNA, or dominant negative constructs. We also establish a control for CRISPR in Xenopus by editing a gene (slc45a2) that when knocked out results in albinism without altering kidney development. This study establishes the feasibility of tissue-specific gene knockout in Xenopus, providing a cost-effective and efficient method for assessing the roles of genes implicated in developmental abnormalities that is amenable to high-throughput gene or drug screening techniques.
Selenkonzentration im Serum und Glutathionperoxidaseaktivität im Vollblut bei gesunden adulten Pferden
Authors: Wolff Felicia , Müller Anja-Elvira , Moschos Anastasios , Köller Gabor , Bauer Achim , Vervuert Ingrid 
Published: November 2017

ZusammenfassungGegenstand und Ziel: Überprüfung des Selenstatus von Pferden anhand der Konzentration von Selen (Se) im Serum und der Glutathionperoxidaseaktivität im Vollblut (GPx) zur Ableitung von Referenzbereichen. Material und Methoden: Warmblutpferde aus zwei Betrieben wurden bis zu viermal im Abstand von mindestens 3 Monaten beprobt. Für einen Rassenvergleich fand in drei Betrieben einmalig eine Blutprobenentnahme bei Vollblutpferden, Islandpferden bzw. Kaltblütern statt. Daraus resultierten insgesamt 1167 Blutproben von 528 klinisch gesunden Pferden. Die-Se-Konzentration wurde massenspektrometrisch analysiert, die GPx-Aktivität in heparinisiertem Vollblut photometrisch gemessen und auf den Hämatokrit bezogen. Das Referenzintervall umfasst die zentralen 95% der Werte aller gesammelten Proben adulter (Alter > 1 Jahr) Warmblüter. Ergebnisse: Die Se-Konzentration im Serum betrug 96 ± 38 µg/l, die GPx-Aktivität im Vollblut 94 ± 40 U/ml Hkt (Mittelwert ± Standardabweichung; n = 1167). Bei 48% der Pferde ergaben sich Se-Werte unterhalb des aktuellen Referenzbereichs von 100–200 µg/l. Alter, Rasse, Standort, Fütterung und Jahreszeit hatten einen Einfluss auf den Se-Status der Pferde. Die Korrelation zwischen der GPx-Aktivität und der Se-Konzentration ließ sich mit der linearen Regressionsgleichung y = 0,73 x + 23,76 beschreiben (y = GPx-Aktivität, x = Se) und es bestand eine signifikante positive Korrelation von r = 0,7. Der aus allen Proben (n = 909) adulter Warmblutpferde berechnete Bereich zwischen 2,5%- und 97,5%-Perzentil betrug für die Se-Konzentrationen 34–167 µg/l und für die GPx-Aktivität 34–175 U/ml Hkt. Schlussfolgerung und klinische Relevanz: Aufgrund der hohen prozentualen Anteils gesunder Pferde, deren Se-Werte nicht im Referenzbereich lagen, scheint der bisher geltende Referenzbereich von 100–200 µg/l zu hoch angesetzt zu sein. Anhand der erhobenen Werte wird für die Se-Konzentration im Serum ein Referenzbereich von 70–170 µg/l vorgeschlagen. Als ergänzender Parameter lässt sich die GPx-Aktivität im Vollblut nutzen, für die ein Referenzbereich von 50–175 U/ml Hkt empfohlen wird.