bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of transport and water retention properties of damaged Callovo-Oxfordian claystone
Authors: M'Jahad S. , Davy C. A. , Skoczylas F. , Talandier J. 
Published: December 2016

Abstract
In the context of the underground storage of radioactive waste, the aim of this experimental study is to characterize the effect of damage on transport and water retention properties of Callovo-Oxfordian (COx) argillite. The originality of the study is to simultaneously investigate the pore-size distribution, water retention, the dry, effective and relative gas permeability, and the gas breakthrough pressure (GBP) of damaged COx argillite. These different properties are all relevant to characterizing the fluid transport ability of COx argillite.
Results show that the damage has a significant impact on the properties of the COx argillite. It induces a decrease in its water retention capacity and GBP, and it increases its gas permeability and apparent porosity available to water owing to the creation of micro-cracks.

Another objective is to show which of these properties is the most suitable to detect early damage states in COx argillite, with a potential use being to identify them
in situ
. GBP appears to be the best ‘detector’ of damage because of its sensitivity to damage even under high confinement pressures. Gas permeability could be a good indicator of damage, as it increases significantly (one or several orders of magnitude) after the damage. Finally, the water permeability curve is a poor indicator of COx argillite damage.
Elevated 20-HETE impairs coronary collateral growth in metabolic syndrome via endothelial dysfunction
Authors: Joseph Gregory , Soler Amanda , Hutcheson Rebecca , Hunter Ian , Bradford Chastity , Hutcheson Brenda , Gotlinger Katherine H. , Jiang Houli , Falck John R. , Proctor Spencer , Schwartzman Michal Laniado , Rocic Petra 
Published: December 2016

Coronary collateral growth (CCG) is impaired in metabolic syndrome (MetS). microRNA-145 (miR-145-Adv) delivery to our rat model of MetS (JCR) completely restored and neutrophil depletion significantly improved CCG. We determined whether low endogenous levels of miR-145 in MetS allowed for elevated production of 20-hydroxyeicosatetraenoic acid (20-HETE), which, in turn, resulted in excessive neutrophil accumulation and endothelial dysfunction leading to impaired CCG. Rats underwent 0–9 days of repetitive ischemia (RI). RI-induced cardiac CYP4F (neutrophil-specific 20-HETE synthase) expression and 20-HETE levels were increased (4-fold) in JCR vs. normal rats. miR-145-Adv and 20-HETE antagonists abolished and neutrophil depletion (blocking antibodies) reduced (~60%) RI-induced increases in CYP4F expression and 20-HETE production in JCR rats. Impaired CCG in JCR rats (collateral-dependent blood flow using microspheres) was completely restored by 20-HETE antagonists [collateral-dependent zone (CZ)/normal zone (NZ) flow ratio was 0.76 ± 0.07 in JCR + 20-SOLA, 0.84 ± 0.05 in JCR + 20-HEDGE vs. 0.11 ± 0.02 in JCR vs. 0.84 ± 0.03 in normal rats]. In JCR rats, elevated 20-HETE was associated with excessive expression of endothelial adhesion molecules and neutrophil infiltration, which were reversed by miR-145-Adv. Endothelium-dependent vasodilation of coronary arteries, endothelial nitric oxide synthase (eNOS) Ser1179 phosphorylation, eNOS-dependent NO·− production and endothelial cell survival were compromised in JCR rats. These parameters of endothelial dysfunction were completely reversed by 20-HETE antagonism or miR-145-Adv delivery, whereas neutrophil depletion resulted in partial reversal (~70%). We conclude that low miR-145 in MetS allows for increased 20-HETE, mainly from neutrophils, which compromises endothelial cell survival and function leading to impaired CCG. 20-HETE antagonists could provide viable therapy for restoration of CCG in MetS. NEW & NOTEWORTHY Elevated 20-hydroxyeicosatetraenoic acid (20-HETE) impairs coronary collateral growth (CCG) in metabolic syndrome by eliciting endothelial dysfunction and apoptosis via excessive neutrophil infiltration. 20-HETE antagonists completely restore coronary collateral growth in metabolic syndrome. microRNA-145 (miR-145) is an upstream regulator of 20-HETE production in metabolic syndrome; low expression of miR-145 in metabolic syndrome promotes elevated production of 20-HETE.
Cardiac sympathetic innervation via middle cervical and stellate ganglia and antiarrhythmic mechanism of bilateral stellectomy
Authors: Irie Tadanobu , Yamakawa Kentaro , Hamon David , Nakamura Keijiro , Shivkumar Kalyanam , Vaseghi Marmar 
Published: December 2016

Cardiac sympathetic denervation (CSD) is reported to reduce the burden of ventricular tachyarrhythmias [ventricular tachycardia (VT)/ventricular fibrillation (VF)] in cardiomyopathy patients, but the mechanisms behind this benefit are unknown. In addition, the relative contribution to cardiac innervation of the middle cervical ganglion (MCG), which may contain cardiac neurons and is not removed during this procedure, is unclear. The purpose of this study was to compare sympathetic innervation of the heart via the MCG vs. stellate ganglia, assess effects of bilateral CSD on cardiac function and VT/VF, and determine changes in cardiac sympathetic innervation after CSD to elucidate mechanisms of benefit in 6 normal and 18 infarcted pigs. Electrophysiological and hemodynamic parameters were evaluated at baseline, during bilateral stellate stimulation, and during bilateral MCG stimulation in 6 normal and 12 infarcted animals. Bilateral CSD (removal of bilateral stellates and T2 ganglia) was then performed and MCG stimulation repeated. In addition, in 18 infarcted animals VT/VF inducibility was assessed before and after CSD. In infarcted hearts, MCG stimulation resulted in greater chronotropic and inotropic response than stellate ganglion stimulation. Bilateral CSD acutely reduced VT/VF inducibility by 50% in infarcted hearts and prolonged global activation recovery interval. CSD mitigated effects of MCG stimulation on dispersion of repolarization and T-peak to T-end interval in infarcted hearts, without causing hemodynamic compromise. These data demonstrate that the MCG provides significant cardiac sympathetic innervation before CSD and adequate sympathetic innervation after CSD, maintaining hemodynamic stability. Bilateral CSD reduces VT/VF inducibility by improving electrical stability in infarcted hearts in the setting of sympathetic activation. NEW & NOTEWORTHY Sympathetic activation in myocardial infarction leads to arrhythmias and worsens heart failure. Bilateral cardiac sympathetic denervation reduces ventricular tachycardia/ventricular fibrillation inducibility and mitigates effects of sympathetic activation on dispersion of repolarization and T-peak to T-end interval in infarcted hearts. Hemodynamic stability is maintained, as innervation via the middle cervical ganglion is not interrupted. Listen to this article's corresponding podcast at https://ajpheart.podbean.com/e/anti-arrhythmic-mechanism-of-bilateral-stellectomy/ .
Un asunto menor, administrativo: la universidad y el management
Authors: Mandiola Marcela , Varas Alejandro 
Published: December 2016

La universidad, su práctica y sus objetivos, han estado en la discusión pública desde hace años. En este artículo reflexionamos acerca de dos discursos principales que han jugado un rol central en la articulación de lo que hoy conocemos como academia en Chile. Lo masculino y managerial le han dado un carácter particular a la universidad en Chile. En otras palabras, la universidad se ha constituido desde un quehacer productivista que busca su optimización a través de la eficiencia y la eficacia. En ese proceso, su dimensión política ha quedado invisibilizada.
Cooperación un tema pendiente para la innovación empresarial
Authors: Geldes Cristian , Heredia Jorge 
Published: December 2016

En los últimos años, la innovación se ha destacado como uno de los principales caminos para incrementar la competitividad y sostenibilidad de las empresas. Este artículo plantea la cooperación empresarial como un elemento clave para promover la innovación, desde una perspectiva teórica y práctica. Luego se discute el estado de la cooperación empresarial en Chile. Por último, se platean desafíos y propuestas para incrementar la colaboración de las empresas con el objeto de aumentar la innovación.
Dose–Response Relationship between Inorganic Arsenic Exposure and Lung Cancer among Arseniasis Residents with Low Methylation Capacity
Authors: Hsu Kuang-Hung , Tsui Ke-Hung , Hsu Ling-I , Chiou Hung-Yi , Chen Chien-Jen 
Published: December 2016

Abstract
Background: Exposure to inorganic arsenic (InAs) has been documented as a risk factor for lung cancer. This study examined the association between InAs exposure, its metabolism, and lung cancer occurrence.
Methods: We followed 1,300 residents from an arseniasis area in Taiwan, determined urinary InAs metabolites, and identified 39 lung cancer cases. Cox proportional hazards model was performed.
Results: The results demonstrated that participants with either the primary methylation index [monomethylarsonic acid (MMA)/InAs] or the secondary methylation index [dimethylarsenic acid (DMA)/MMA] lower than their respective median values were at a higher risk of lung cancer (HRs from 3.41 to 4.66) than those with high methylation capacity. The incidence density of lung cancer increased from 79.9/100,000 (year−1) to 467.4/100,000 (year−1) for residents with low methylation capacity and from 0 to 158.5/100,000 (year−1) for residents with high methylation capacity when the arsenic exposure dose increased from 2 to 10 ppb to ≥200 ppb, respectively. The analyses revealed a dose–response relationship between lung cancer occurrence and increasing arsenic concentrations in drinking water as well as cumulative arsenic exposure (monotonic trend test; P &lt; 0.05 and P &lt; 0.05, respectively) among the residents with low methylation capacity. The relationship between arsenic exposure and lung cancer among high methylators was not statistically significant.
Conclusions: Hypomethylation responses to InAs exposure may dose dependently increase lung cancer occurrence.
Impact: The high-risk characteristics observed among those exposed should be considered in future preventive medicine and research on arsenic carcinogenesis. Cancer Epidemiol Biomarkers Prev; 26(5); 756–61. ©2016 AACR.
Combined KIT and CTLA-4 Blockade in Patients with Refractory GIST and Other Advanced Sarcomas: A Phase Ib Study of Dasatinib plus Ipilimumab
Authors: D'Angelo Sandra P. , Shoushtari Alexander N. , Keohan Mary Louise , Dickson Mark A. , Gounder Mrinal M. , Chi Ping , Loo Jennifer K. , Gaffney Leigh , Schneider Lee , Patel Zarine , Erinjeri Joseph Patrick , Bluth Mark J. , Sjoberg Ana , Streicher Howard , Takebe Naoko , Qin Li-Xuan , Antonescu Cristina , DeMatteo Ronald P. , Carvajal Richard D. , Tap William D. 
Published: December 2016

Abstract
Purpose: A phase Ib study of dasatinib plus ipilimumab in patients with gastrointestinal stromal tumor (GIST) and other sarcomas was performed on the basis of preclinical data demonstrating that combined KIT and CTLA-4 blockade is synergistic.
Experimental Design: A standard 3 + 3 design was used to evaluate the safety, efficacy, and immune correlates of treatment. Dose escalation cohorts received ipilimumab 10 or 3 mg/kg every 3 weeks, followed by maintenance every 12 weeks with escalating doses of dasatinib (70 mg daily, 100 mg daily, or 70 mg twice daily). Response was assessed by RECIST 1.1, Choi, and immune-related RECIST criteria (irRC).
Results: A total of 28 patients (17 male) were enrolled. Histologic subtypes included GISTs (n = 20) and other sarcomas (n = 8.) Dasatinib 70 mg/day with ipilimumab 10 mg/kg or dasatinib 140 mg/day with ipilimumab 3 mg/kg can be safely administered. Dose-limiting toxicities included grade 3 gastric hemorrhage and anemia. No partial or complete responses were noted by RECIST or irRC. There were 7 of 13 partial responses in the GIST patients by Choi criteria, and 3 of 13 patients each had stable and progressive disease, respectively.
Conclusions: Dasatinib and ipilimumab can be safely administered to GIST and sarcoma patients. However, dasatinib was not synergistic with ipilimumab, as there was limited clinical efficacy with the combination. This limited cohort provides prospective data that indoleamine-2,3-dioxygenase (IDO) suppression may potentially correlate with antitumor efficacy in GIST. Given the small cohort, it is only hypothesis generating and additional data would be required. In the era of more modern and effective checkpoint inhibitors, next steps could be consideration of tyrosine kinase inhibitors or IDO inhibitors in combination with anti-PD-1 therapy. Clin Cancer Res; 23(12); 2972–80. ©2016 AACR.
Inventário poético para uma morte (des)figurada
Authors: Oliveira Rodrigo Santos de 
Published: December 2016

Este estudo pretende analisar a representação da morte na poesia de Hilda Hilst desde as obras iniciais até Da morte. Odes mínimas (1980), em que o significante temático se instala numa poética de (des)figuração. Para delinear essa hipótese, serão consideradas as seguintes máscaras discursivas da morte: o feminino, o animal e o duplo. A catalogação desses disfarces permite ler a obra a partir do formato inventário.
Pela sobrevivência da narrativa: a dificuldade do ato de narrar em "Os sobreviventes", de Caio Fernando Abreu
Authors: Franco Adenize 
Published: December 2016

Este trabalho propõe algumas reflexões a respeito do conto "Os sobreviventes", de Caio Fernando Abreu. A intenção é demonstrar como o aspecto da negatividade, enquanto construção do sujeito, conduz a uma narrativa em que não há elementos fixos tampouco estáveis, seja de espaço, de tempo ou de voz discursiva. Esse deslocamento corrobora a ideia de que existe uma dificuldade do ato de narrar, condicionada pelas mudanças sociais ocorridas no contexto de produção do conto e que contribui para a caracterização estética e política da narrativa.
Estatuária do desejo: a escrita erótica e o jogo da imitação em "Lucíola"
Authors: Ferraz Geovanina Maniçoba 
Published: December 2016

Lucíola, published in 1862, deals with the brief involvement of a young provincial man with a beautiful courtesan. The desire, even when denied, takes a central role in the plot, moving characters and narrative towards the premature death of the protagonist. This outcome is due to complications of abortion, a consequence of sex, somehow engaging an allegory between Eros and Thanatos. The narrator admits the immorality of his text, but says he will not hide himself on the hypocrisy of ellipsis. It’s impossible to recognize in the book some concern towards the way you show lust through words. The analysis of three erotic scenes and its relations with other passages of the novel aims to contribute to the understanding of this process of representation.
A relação entre pessoas e animais em contos de "A legião estrangeira", de Clarice Lispector
Authors: Teles Ana Carolina Sá 
Published: December 2016

Este artigo desenvolve a leitura de três contos de A legião estrangeira, de Clarice Lispector: “Macacos”, “Tentação” e “A legião estrangeira”. Nele, busca-se debater como a figuração de animais revela-se elemento importante no projeto estético de Clarice Lispector. Nesse sentido, observo que os animais agem como gatilhos que operam no descentramento da composição de personagens humanas, além de estarem envolvidos em impasses de ordem ética que estão implicados no relacionamento entre sujeito e alteridade. Parte-se de um questionamento da recepção que Hélène Cixous realizou da obra clariciana no que diz respeito aos limites na relação com o outro, especialmente nos ensaios “Clarice Lispector: The Approach” e “Reaching the Point of Wheat, or A Portrait of the Artist as a Maturing Woman”. Para tanto, recorro à fundamentação crítica de Marta Peixoto e de Anna Klobucka na abordagem reflexiva de textos de Cixous e de Lispector. Por fim, discutem-se especificamente os contos da coletânea de 1964.
As relações entre texto e cena: a presença e o corpo
Authors: Ferraz Geovanina Maniçoba 
Published: December 2016

A edição 8 da Opiniães se propõe a investigar as relações entre literatura e teatro. Com o objetivo de trazer um espectro variado de opiniões sobre o tema, convidamos escritores, dramaturgos, diretores, atores, professores, críticos, gente da academia e de fora dela, para nos ajudar a pensar as relações entre texto e cena. Nossos autores convidados, cujas contribuições foram organizadas ecomentadas por Nina Maniçoba Ferraz, são: Adriana Calabró, Deise Abreu Pacheco, Juliana Jardim, Luiz Pimentel, Marcos Gomes, Maria Sílvia Betti, Mario Tommaso, Miguel Prata, Paula Autran e Vilma Arêas.
Em torno do olho da rua
Authors: Almeida Aline Novais de , Teles Ana Carolina Sá , Visnadi Marcos De Campos 
Published: December 2016

Os dezesseis artigos que compõem o dossiê do n. 9 da Opiniães - Revista dos alunos de Literatura Brasileira entram na cidade por suas próprias vias. Entre flâneurs e monumentos, meio bossa nova e rock’n’roll, estudantes de graduação e pós-graduação enviaram suas leituras de obras de Machado de Assis, Carlos Drummond de Andrade, Rubem Fonseca, João Antônio, Renato Russo, Evandro Affonso Ferreira, Milton Hatoum, Chico Buarque, entre outros, buscando uma convergência com temas da arquitetura e do urbanismo para encontrar, na literatura, uma forma particular de representar, imaginar, lembrar e esquecer a cidade. A edição também apresenta uma entrevista com a professora Sophial Beal (Universidade de Minesota), uma resenha sobre livro da autora, além de poemas e contos inéditos na seção de "Criação Literária".
Adam17
Deficiency Promotes Atherosclerosis by Enhanced TNFR2 Signaling in Mice
Authors: Nicolaou Alexandros , Zhao Zhen , Northoff Bernd H. , Sass Kristina , Herbst Andreas , Kohlmaier Alexander , Chalaris Athena , Wolfrum Christian , Weber Christian , Steffens Sabine , Rose-John Stefan , Teupser Daniel , Holdt Lesca M. 
Published: December 2016

Objective—
ADAM17 (a disintegrin and metalloproteinase 17) is a sheddase releasing different types of membrane-bound proteins, including adhesion molecules, cytokines, and their receptors as well as inflammatory mediators. Because these substrates modulate important mechanisms of atherosclerosis, we hypothesized that ADAM17 might be involved in the pathogenesis of this frequent disease.

Approach and Results—

Because
Adam17
-knockout mice are not viable, we studied the effect of
Adam17
deficiency on atherosclerosis in
Adam17
hypomorphic mice (
Adam17
ex/ex
), which have low residual
Adam17
expression. To induce atherosclerosis, mice were crossed onto the low-density lipoprotein receptor (
Ldlr
)-deficient background. We found that
Adam17
ex/ex
.Ldlr
−/−
mice developed ≈1.5-fold larger atherosclerotic lesions, which contained more macrophages and vascular smooth muscle cells than wild-type littermate controls (
Adam17
wt/wt
.Ldlr
−/−
). Reduced
Adam17
-mediated shedding led to significantly increased protein levels of membrane-resident TNFα (tumor necrosis factor) and TNFR2 (tumor necrosis factor receptor 2), resulting in a constitutive activation of TNFR2 signaling. At the same time,
Adam17
deficiency promoted proatherosclerotic cellular functions, such as increased proliferation and reduced apoptosis in cultured macrophages and vascular smooth muscle cells and increased adhesion of macrophages to vascular endothelial cells. Because siRNA (small interfering RNA)-mediated knockdown of
Tnfr2
rescued from aberrant proliferation and from misregulation of apoptosis in
Adam17
-depleted cells, our data indicate that TNFR2 is an important effector of ADAM17 in our mouse model.

Conclusions—
Our results provide evidence for an atheroprotective role of ADAM17, which might be mediated by cleaving membrane-bound TNFα and TNFR2, thereby preventing overactivation of endogenous TNFR2 signaling in cells of the vasculature.
AMOBES (Active Mobility Very Early After Stroke)
Authors: Yelnik Alain P. , Quintaine Victorine , Andriantsifanetra Cedric , Wannepain Marie , Reiner Peggy , Marnef Hélène , Evrard Mathilde , Meseguer Elena , Devailly Jean Pascal , Lozano Monica , Lamy Catherine , Colle Florence , Vicaut Eric , Andriantsifanétra Cédric , Barbi Margaux , Brans Julien , Chabriat Hugues , Mawet Jerome , Wanepain Marie , Amarenco Pierre , Dien Agnes , Ortega Balma , Perez Sylvia , Baudrat Estelle , Blondel Marine , Kemlin Claire , Leger Anne , Potet Alexia , Samson Yves , Acevedo Raquel , Broglin Bénédicte , Brulant Myriam , Lopez Cristina Lopez , Mas Jean Louis , Melgosa Elena , Monchaud Cédric , Paquereau Julie , Aguilera David , Aymard Claire , Birnbaum Simone , Nguyen-Thuyet Bérangère , Tamazyan Ruben , Zuber Mathieu , Hamon Christelle , Le Tarnec Julien , Médée Béatrice , Rémy-Néris Olivier , Timsit Serge , Graciès Jean Michel , Hosseini Hassan , Loche Catherine Marie , Rondeau Emilie , Troel Sarah , Barbieux Marianne , Detante Olivier , Garambois Katia , Marquer Adelaide , Payen Grégoire , Pérennou Dominic , Véjux Pascale , Thuriot Antoine , Ducrocq Xavier , Croci Lionel , Khalil Nathalie , Paysant Jean , Bussone Julie , Mokadmi Sara , Reboullet Florence , Rousseau Hélène 
Published: December 2016

Background and Purpose—
Intensive physical therapy (PT) facilitates motor recovery when provided during a subacute stage after stroke. The efficiency of very early intensive PT has been less investigated. We aimed to investigate whether intensive PT conducted within the first 2 weeks could aid recovery of motor control.

Methods—
This multicentre randomized controlled trial compared soft PT (20-min/d apart from respiratory needs) and intensive PT (idem+45 minutes of intensive exercises/day) initiated within the first 72 hours after a first hemispheric stroke. The primary outcome was change in motor control between day (D) 90 and D0 assessed by the Fugl–Meyer score. Main secondary outcomes were number of days to walking 10 m unassisted, balance, autonomy, quality of life, and unexpected medical events. All analyses were by intent to treat.

Results—

We could analyze data for 103 of the 104 included patients (51 control and 52 experimental group; 64 males; median age overall 67 [interquartile range 59–77], 67 right hemispheric lesions, 80 ischemic lesions, National Institutes of Health Stroke Scale score ≥8 for 82%). Fugl–Meyer score increased over time (
P
<0.0001), with no significant effect of treatment (
P
=0.29) or interaction between treatment and time (
P
=0.40). The median change in score between D90 and D0 was 27.5 (12–40) and 22.0 (12–56) for control and experimental groups (
P
=0.69). Similar results were found for the secondary criteria.

Conclusions—
Very early after stroke, intensive exercises may not be efficient in improving motor control. This conclusion may apply to mainly severe stroke.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01520636.