bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mémoire et fiction : apports de la littérature à l’approche psychothérapique des troubles démentiels
Authors: Peretti Pascale 
Published: October 2016

Depuis les prémisses de la culture occidentale, l’oubli nous est présenté sous son visage délétère, notamment à travers les traditions mythologiques et philosophiques de la Grèce Antique. Cette face obscure de Léthé n’est pas sans évoquer les conséquences mutilantes des pertes neuro-cognitives vécues par les patients déments. Pourtant, un autre visage de l’oubli se fait également jour dans l’histoire littéraire occidentale, qui nous donne à appréhender ses vertus potentiellement salvatrices et aperturales. Aussi, à partir de quelques œuvres littéraires, interrogeons-nous ici les rapports de la mémoire, de l’oubli, de la fiction et de l’identité, ainsi que le « double sens » de l’oubli chez les sujets engagés dans des processus démentiels. Ce qui nous amène à éclairer la valeur et la portée d’une « clinique du sujet » dans l’approche psychothérapique des troubles démentiels.
Cell Signaling Pathways That Regulate Antigen Presentation
Authors: Brutkiewicz Randy R. 
Published: October 2016

Abstract
Cell signaling pathways regulate much in the life of a cell: from shuttling cargo through intracellular compartments and onto the cell surface, how it should respond to stress, protecting itself from harm (environmental insults or infections), to ultimately, death by apoptosis. These signaling pathways are important for various aspects of the immune response as well. However, not much is known in terms of the participation of cell signaling pathways in Ag presentation, a necessary first step in the activation of innate and adaptive T cells. In this brief review, I discuss the known signaling molecules (and pathways) that regulate how Ags are presented to T cells and the mechanism(s), if identified. Studies in this area have important implications in vaccine development and new treatment paradigms against infectious diseases, autoimmunity, and cancer.
NK Cell Responses Redefine Immunological Memory
Authors: Adams Nicholas M. , O’Sullivan Timothy E. , Geary Clair D. , Karo Jenny M. , Amezquita Robert A. , Joshi Nikhil S. , Kaech Susan M. , Sun Joseph C. 
Published: October 2016

Abstract
Immunological memory has traditionally been regarded as a unique trait of the adaptive immune system. Nevertheless, there is evidence of immunological memory in lower organisms and invertebrates, which lack an adaptive immune system. Despite their innate ability to rapidly produce effector cytokines and kill virally infected or transformed cells, NK cells also exhibit adaptive characteristics such as clonal expansion, longevity, self-renewal, and robust recall responses to antigenic or nonantigenic stimuli. In this review, we highlight the intracellular and extracellular requirements for memory NK cell generation and describe the emerging evidence for memory precursor NK cells and their derivation.
NO-tryptophan: a new small molecule located in the rat brain
Authors: Mangas A. , Yajeya J. , González N. , Duleu S. , Geffard M. , Coveñas R. 
Published: October 2016

<p>A highly specific monoclonal antibody directed against nitric oxide-tryptophan (NO-W) with good affinity (10<sup>-9 </sup>M) and specificity was developed. In the rat brain, using an indirect immunoperoxidase technique, cell bodies containing NO-W were exclusively found in the intermediate and dorsal parts of the lateral septal nucleus. No immunoreactive fibres were found in the rat brain. This work reports the first visualization and the morphological characteristics of cell bodies containing NO-W in the mammalian brain. The restricted distribution of NO-W in the rat brain suggests that this molecule could be involved in specific physiological mechanisms. </p>
Transport engineering and reduction in crime: the Medellín case
Authors: Colomer Bea David 
Published: October 2016

This study analyses the impact of the aerial cable car public transport system, locally known as Metrocable, in Medellín (Colombia), on the reduction in crime. As part of the municipal policies of social urbanism, Metrocable has contributed to the social integration of the population in the outlying neighbourhoods, which has increased safety in Medellín. This case is clearly of great interest from the point of view of Criminal Sciences, demonstrating how crime can be combated by using tools beyond ius puniendi. DOI: http://dx.doi.org/10.4995/CIT2016.2016.3434
Análisis de Sensibilidad de una Metodología de Decisión Multicriterio desarrollada para la Selección de Tipologías de Estructuras de Contención en una Autovía Urbana
Authors: MUÑOZ BELEN , ROMANA MANUEL , ORDOÑEZ JAVIER 
Published: October 2016

Los métodos de decisión multicriterio son una herramienta que reduce la subjetividad en la toma de decisiones mediante la creación de una serie de filtros de selección y ayuda a la elección entre alternativas complejas. Permite a los proyectistas estructurar la información de forma racional y poder exponerla de forma clara, así como la identificación precisa y ordenada todos los elementos que determinan que un diseño sea el idóneo, y al mismo tiempo se consideren y valoren todas las alternativas posibles que da solución al problema. Pueden tener propósitos diferentes en cada una de las etapas de selección de alternativas, en primer lugar puede ayudar a analizar el problema, tarea u objetivo al descomponerlo en un número finito de requisitos, y una vez establecido los requisitos ayuda a su ordenación por la importancia relativa o peso de cada criterio para cada alternativa. Frente a estas ventajas, presentan un inconveniente muy importante que es la subjetividad a la hora de asignar pesos a cada criterio y la valoración de las diferentes alternativas por el decisor. En la presente comunicación se realiza un análisis de sensibilidad que valida la metodología desarrollada en el marco de una investigación que establece un proceso sistemático de decisión a partir de la aplicación de forma secuencial de varios métodos de decisión multicriterio, de manera que se reduzca en todo lo posible la subjetividad asociada a cualquier proceso de decisión. El análisis de sensibilidad determina cómo varía la selección de alternativas cuando varía la importancia relativa de los criterios o requerimientos de proyecto considerados como determinantes en el proceso de selección.DOI: http://dx.doi.org/10.4995/CIT2016.2016.3491
COMPARATIVE STUDY OF LIBERALIZATION PROCESS OF PASSENGERS RAILWAY MARKET IN SPAIN AND ENGLAND
Authors: Fernández Aracil Patricia , Fernández Morote Graciela , Ortuño Padilla Armando 
Published: October 2016

This article provides an overview of the privatization of railway passengers market in Spain through a background to the most relevant cases studies in Europe, particularly the liberalization process in England. The English case study is a paradigmatic example to assess how the liberalization process was developed and its effect in the present. This assessment has been undertaken to analyse the railway franchise structure, ticketing measures, role of national and regional authorities, etc. and possible analogies to be adapted to the case of Spain. Firstly, this article reviews the origin of the privatization of the railway market in both Spain and England, describing every phase of the liberalization and the success of every stage. Secondly, a critical approach assessment exposes those market failures of the liberalization process in England that caused negative impacts on society. In addition, the role of the Government is analysed to measure their implication in order to solve that situation. Furthermore, the paper expounds a wide analysis of the rail ticketing in England, its effects on increased passenger number. Finally, this article proposes some measures to be followed on the privatization of passenger rail market in Spain, as well as some key concepts to guarantee its success as taken from the case studies that have been reviewed.DOI: http://dx.doi.org/10.4995/CIT2016.2016.3522
Environmental innovation through transport policy. The implementation of the free fare policy on public transport in Tallinn, Estonia
Authors: Gabaldón-Estevan Daniel 
Published: October 2016

Urban areas are of increasing relevance when it comes to sustainability. • First, about half of the world’s population now lives in cities (increasing to 60% by 2030). • Second, cities are nowadays responsible for levels of resource consumption and waste generation that are higher beyond their share on world population. • Third, cities are more vulnerable to disruptive events that can lead to restrictions on the provision of resources and to changes on the environment caused by climate change. • And fourth, because they concentrate key resources (political, social, cultural…), cities are seen as strategic scenarios where to experiment and develop solutions to cope with the prevailing sustainability challenges driven by the major social and environmental transformations. Urban agglomerations can be seen as complex innovation systems where human activities are shaped in order to transform societies towards sustainable development. For this paper, we focus on the case of an environmental innovation regarding transport policy, the implementation of the fare-free policy on public transport for all inhabitants of Tallinn, Estonia. Tallinn, with 414,000 inhabitants in 2015, is the capital of Estonia and the largest city in the country. Over the last two decades the share of public transport trips decreased dramatically. After a public opinion poll in 2012, in which over 75% of the participants voted for a fare-free public transportation system (FFPTS) in Tallinn, the new policy was implemented on 1st January 2013. From that date on inhabitants of Tallinn could use all public transport services (busses, trams, trolly-busses) operated by city-run operators for free. Later the fare-free system was implemented also on trains within Tallinn. In this paper we analyze the context, in which this policy was implemented, the main characteristics of its implementation and its actual situation.DOI: http://dx.doi.org/10.4995/CIT2016.2016.3532
BALANCE DEL PLAN DE MODERNIZACIÓN DE LOS SERVICIOS INTERURBANOS POR AUTOBÚS
Authors: Andújar Martínez Montserrat , Tarruella Vidal Elena , Nieto Corella Berta , León Fariñas María del Amor 
Published: October 2016

El Plan de Modernización de los servicios de transporte público regular permanente de viajeros del Consorcio Regional de Transportes de Madrid, aprobado a finales de 2009, tiene como objetivo revitalizar el servicio de transporte en los autobuses urbanos e interurbanos de la Comunidad de Madrid. Este Plan abarca tanto a los vehículos como a la tecnología necesaria para la mejora del servicio y de la información al usuario. Las mejoras llevadas a cabo han implicado unos desarrollos e inversiones cuantiosos como la instalación de los SAEs, implantación del sistema de ticketing sin contacto, instalación de displays embarcados, cámaras de videovigilancia, información en tiempo real a través de diferentes soportes (Pantallas en paradas o intercambiadores, Aplicaciones móviles,…), adaptación de los vehículos para mejorar la accesibilidad a personas de movilidad reducida,… Tras seis años de intenso trabajo, tanto por parte de la Administración como de las empresas operadoras, se han alcanzado unos estándares elevados en la totalidad de los aspectos, habiéndose cumplido los objetivos perseguidos, con carácter general, como demuestran los resultados de las encuestas de satisfacción a los usuarios. Además, dentro de este marco, en los últimos años, se han ido desarrollando nuevos aspectos tecnológicos, que serán fundamentales para el buen desarrollo de las labores del Consorcio, como son la integración de la información en tiempo real de todos los operadores en el CITRAM, la utilización de las herramientas de gestión de incidencias y afecciones, etc.DOI: http://dx.doi.org/10.4995/CIT2016.2016.4269
Distribution and sources of air pollutants in the North China Plain based on
on-road mobile measurements
Authors: Zhu Yi , Zhang Jiping , Wang Junxia , Chen Wenyuan , Han Yiqun , Ye Chunxiang , Li Yingruo , Liu Jun , Zeng Limin , Wu Yusheng , Wang Xinfeng , Wang Wenxing , Chen Jianmin , Zhu Tong 
Published: October 2016

Abstract. The North China Plain (NCP) has been experiencing severe air pollution problems with rapid economic growth and urbanisation. Many field and model studies have examined the distribution of air pollutants in the NCP, but convincing results have not been achieved, mainly due to a lack of direct measurements of pollutants over large areas. Here, we employed a mobile laboratory to observe the main air pollutants in a large part of the NCP from 11 June to 15 July 2013. High median concentrations of sulfur dioxide (SO2) (12 ppb), nitrogen oxides (NOx) (NO + NO2; 452 ppb), carbon monoxide (CO) (956 ppb), black carbon (BC; 5.5 µg m−3) and ultrafine particles (28 350 cm−3) were measured. Most of the high values, i.e. 95 percentile concentrations, were distributed near large cities, suggesting the influence of local emissions. In addition, we analysed the regional transport of SO2 and CO, relatively long-lived pollutants, based on our mobile observations together with wind field and satellite data analyses. Our results suggested that, for border areas of the NCP, wind from outside this area would have a diluting effect on pollutants, while south winds would bring in pollutants that have accumulated during transport through other parts of the NCP. For the central NCP, the concentrations of pollutants were likely to remain at high levels, partly due to the influence of regional transport by prevalent south–north winds over the NCP and partly by local emissions.
Effect of iron oxide on nitrification in two agricultural soils with
different pH
Authors: Huang Xueru , Zhu-Barker Xia , Horwath William R. , Faeflen Sarwee J. , Luo Hongyan , Xin Xiaoping , Jiang Xianjun 
Published: October 2016

Abstract. Iron (Fe) affects soil nitrogen (N) cycling processes both in anoxic and oxic environments. The role of Fe in soil N transformations including nitrification, mineralization, and immobilization, is influenced by redox activity, which is regulated by soil pH. The effect of Fe minerals, particularly oxides, on soil N transformation processes depends on soil pH, with Fe oxide often stimulating nitrification activity in the soil with low pH. We conducted lab incubations to investigate the effect of Fe oxide on N transformation rates in two subtropical agricultural soils with low pH (pH 5.1) and high pH (pH 7.8). 15N-labeled ammonium and nitrate were used separately to determine N transformation rates combined with Fe oxide (ferrihydrite) addition. Iron oxide stimulated net nitrification in low-pH soil (pH 5.1), while the opposite occurred in high-pH soil (pH 7.8). Compared to the control, Fe oxide decreased microbial immobilization of inorganic N by 50 % in low-pH soil but increased it by 45 % in high-pH soil. A likely explanation for the effects at low pH is that Fe oxide increased NH3-N availability by stimulating N mineralization and inhibiting N immobilization. These results indicate that Fe oxide plays an important role in soil N transformation processes and the magnitude of the effect of Fe oxide is dependent significantly on soil pH.
Biopolyester-Based Systems Containing Naturally Occurring Compounds with Enhanced Thermo-Oxidative Stability
Authors: Arrigo Rossella , Morici Elisabetta , Dintcheva Nadka Tzankova 
Published: October 2016

Background This work presents a sustainable approach for the stabilization of polylactic acid (PLA) against thermo-oxidative aging. Methods Naturally occurring phenolic and polyphenolic compounds, such as ferulic acid (FerAc), vanillic acid (VanAc), quercetin (Querc) and vitamin E (VitE), were introduced into PLA. Results The preliminary characterization of the systems formulated containing different amounts of natural stabilizers showed that all compounds used acted as plasticizers, leading to a decrease in rheological functions with respect to neat PLA, without significantly modifying the crystallinity of the raw material. The study of the thermo-oxidative behavior of neat PLA and PLA/natural compound systems, performed by spectrometric and thermal analyses, indicated that all stabilizers considered were able to exert a remarkable antioxidant action against thermo-oxidative phenomena. Conclusions All natural compounds considered are thus proposed as ecofriendly stabilizers, to get fully bio-based polymer systems with enhanced thermo-oxidative stability, suitable for biomedical applications.
Establishment of Two Data Mining Models of Lung Cancer Screening Based on Three Gene Promoter Methylations Combined with Telomere Damage
Authors: Wang Wei , Feng Xiaolei , Duan Xiaoran , Tan Shanjuan , Wang Sihua , Wang Tuanwei , Feng Feifei , Wu Yiming , Wu Yongjun 
Published: October 2016

Objective To identify the significance of a support vector machine (SVM) model and a decision tree (DT) model for the diagnosis of lung cancer combined with the detection of fragile histidine triad (FHIT), RAS association domain family 1 (RASSF1A) and cyclin-dependent kinase inhibitor 2A (p16) promoter methylation levels and relative telomere length (RTL) of white blood cells from peripheral blood DNA. Methods The levels of p16, RASSF1A and FHIT promoter methylation and the RTL of white blood cells in peripheral blood DNA of 200 healthy individuals and 200 lung cancer patients were analyzed by SYBR Green-based quantitative methylation-specific PCR and quantitative PCR. Based on the 4 biomarkers, SVM and DT models were developed. Results The levels of FHIT, RASSF1A and p16 promoter methylation were 3.33 (1.86-6.40) and 2.85 (1.39-5.44) (p = 0.002); 27.62 (9.09-52.86) and 17.17 (3.86-50.87) (p = 0.038); and 0.59 (0.16-4.50) and 0.36 (0.06-4.00) (p = 0.008) in cases and controls, respectively. RTL was 0.93 ± 0.32 and 1.16 ± 0.57 (p<0.001). The areas under the receiver operating characteristic (ROC) curves of the Fisher discriminant analysis, SVM and DT models were 0.670 (0.569-0.761), 0.810 (0.719-0.882) and 0.810 (0.719-0.882), respectively. Conclusions The SVM and DT models for diagnosing lung cancer were successfully developed through the combined detection of p16, RASSF1A and FHIT promoter methylation and RTL, which provided useful tools for screening lung cancer.
Duplex Ultrasound for the Prediction of Vascular Events Associated with Arteriovenous Fistulas in Hemodialysis Patients
Authors: Ishii Takeo , Suzuki Yasunobu , Nakayama Takuji , Ohmori Miki , Masai Shinichi , Sasagawa Naru , Ohyama Kunio 
Published: October 2016

Objective To determine if duplex ultrasound (US) for arteriovenous fistulas (AVFs) can predict vascular events (VEs; thrombosis and stenosis). Methods Duplex US was performed for vascular access evaluation in 2557 maintenance hemodialysis (HD) patients between October 1, 2013 and March 31, 2016. Of these patients, 2184 patients were finally included in this study. AVF dysfunction was assessed using the brachial artery blood flow volume (Qa; mL/min), arterial blood flow resistance index (RI), and residual diameter of the fistula vein (RD; mm). Proximal, midpoint, and distal aspects of the fistulas were measured. The baseline measurements were the US assessments, and the endpoint was VEs requiring vascular access intervention therapy or vascular surgery. Associations of US findings and VEs were assessed with receiver operating characteristic curve analysis, log-rank analysis, and multivariate Cox hazard models. Results The mean Qa was 772.8 ± 441.4 mL/min; RI, 0.56 ± 0.1; and RD, 2.37 ± 1.0 mm. The optimal Qa cut-off point was calculated as 581.5 mL/min, RI cut-off as 0.56, and RD cut-off as 1.85 mm. VEs were more frequent in patients with a Qa <581.5 mL/min than in those with a Qa >581.5 mL/min (p<0.001). In multivariate analysis, Qa, ferritin, transferrin saturation, and warfarin use were significantly associated with VEs. Conclusions US evaluation of AVFs in HD patients is a simple method to predict the risks of thrombosis and fistula dysfunction. Qa, ferritin, transferrin saturation, and warfarin use might be associated with VEs.
A Modified de novo Insertion Technique for Catheter Replacement in Elderly Hemodialysis Patients: A Single Clinic Retrospective Analysis
Authors: Wang Lihua , Wei Fang , Chen Haiyan , Sun Guijiang , Yu Haibo , Jiang Aili 
Published: October 2016

Purpose For patients who rely on a tunneled cuffed catheter, replacement or catheter removal is typically necessary. We recently performed a modified de novo insertion technique for catheter replacement in our practice. As the technique has not yet been studied comprehensively, we performed a retrospective study to evaluate the safety and efficacy of de novo placed catheter without delay for catheter replacement in elderly hemodialysis patients. Methods A retrospective review of 164 elderly patients was conducted during a period of three years. There were 84 patients in study group, as well as 80 patients in a control group, who had catheter replacement by guidewire exchange technique. Clinical follow-up data was collected. Results All catheters were placed successfully. The mean survival time per catheter was 641 catheter days (study group) and 485 catheter days (control group). The primary patency rates of 30 days were 97.7% (study group) and 90% (control group), respectively, with statistically significant difference (p = 0.04). The incidence of catheter infection was not statistically significantly different in both groups (p = 0.586), but the case of catheter dysfunction was significantly lower in study group compared to control group (p = 0.003). Conclusions The de novo placed catheter without delay technique for catheter replacement near the pre-existing venotomy site is safe, and boasts similar infection rates with lower dysfunction rates compared to tunneled catheter insertion by guidewire exchange technique.
Does Pre- and Post-Angioplasty Doppler Ultrasound Evaluation Help in Predicting Vascular Access Outcome?
Authors: Guedes-Marques Maria , Maia Pedro A. , Neves Fernando , Ferreira Aníbal , Cruz João , Carvalho Dulce , Oliveira Carlos , Barreto Carlos , Carvalho Telmo , Ponce Pedro 
Published: October 2016

Background Kidney Disease – Improving Global Outcomes (KDIGO) recommends post-percutaneous transluminal angioplasty (PTA) <30% residual stenosis (RS) and hemodynamic parameters improvement. Primary end point: how post-PTA access blood flow (ABF) improvement predicts vascular access (VA) outcome. Secondary: compare Doppler ultrasound (DU) and angiography diagnostic accuracy; determine how other factors predict outcome. Methods Eighty patients. DU evaluation performed pre- and post-PTA. Several parameters recorded. Secondary patency verified after 6 months. Results Initial ABF 537 ± 248 mL/min; final ABF 1013 ± 354 mL/min. Number and location of stenosis was highly correlated between DU and angiography (p<0.001); central vessels mismatching. First semester overall survival was 63%; significantly better for fistulas (76%) than grafts (51.7%), p 0.044. Final RS>30% associated to better survival, p 0.038. Initial ABF<500 mL/min and multiple stenosis did not affect outcome (p>0.05). A >2-fold ABF increase had no significant impact on fistulas (p>0.05) but was significantly associated with worst outcomes in grafts (23.1% vs. 73.5%, p 0.009). Grafts had lower survival (HR 3.3, p 0.034). Conclusions Although less accurate for central lesions, DU has a key role on VA surveillance, allowing a morphologic and hemodynamic assessment. Angioplasty is effective in preserving VA; however, it may increase restenosis due to accelerated neointimal hyperplasia. Current parameters are not useful. Trials addressing this issue are needed.