bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case of adrenal Cushing’s syndrome with bilateral adrenal masses
Authors: Guo Ya-Wun , Hwu Chii-Min , Won Justin Ging-Shing , Chu Chia-Huei , Lin Liang-Yu 
Published: May 2016

Summary
A functional lesion in corticotrophin (ACTH)-independent Cushing’s syndrome is difficult to distinguish from lesions of bilateral adrenal masses. Methods for distinguishing these lesions include adrenal venous sampling and 131I-6β-iodomethyl-19-norcholesterol (131I-NP-59) scintigraphy. We present a case of a 29-year-old Han Chinese female patient with a history of hypercholesterolaemia and polycystic ovary syndrome. She presented with a 6month history of an 8kg body weight gain and gradual rounding of the face. Serial examinations revealed loss of circadian rhythm of cortisol, elevated urinary free-cortisol level and undetectable ACTH level (<5pg/mL). No suppression was observed in both the low- and high-dose dexamethasone suppression tests. Adrenal computed tomography revealed bilateral adrenal masses. Adrenal venous sampling was performed, and the right-to-left lateralisation ratio was 14.29. The finding from adrenal scintigraphy with NP-59 was consistent with right adrenal adenoma. The patient underwent laparoscopic right adrenalectomy, and the pathology report showed adrenocortical adenoma. Her postoperative cortisol level was 3.2μg/dL, and her Cushingoid appearance improved. In sum, both adrenal venous sampling and 131I-NP-59 scintigraphy are good diagnostic methods for Cushing’s syndrome presenting with bilateral adrenal masses.

Learning points

The clinical presentation of Cushing’ syndrome includes symptoms and signs of fat redistribution and protein-wasting features.
The diagnosis of patients with ACTH-independent Cushing’s syndrome with bilateral adrenal masses is challenging for localisation of the lesion.
Both adrenal venous sampling and 131I-NP-59 scintigraphy are good methods to use in these patients with Cushing’s syndrome presenting with bilateral adrenal masses.
Fracturas alrededor de una osteosíntesis extramedular previa de fémur proximal. Una solución simple para un problema complejo. [Fractures around a previous proximal femur fixation. A simple solution to a complex problem.]
Authors: Bidolegui Fernando Manuel , Calvo Ximena , Pereira Sebastian , Vindver Gabriel 
Published: May 2016

<p>El número de fracturas de cadera en pacientes ancianos aumenta proporcionalmente al incremento de la expectativa de vida. Por lo tanto encontrarnos con una fractura de fémur, distal a un implante de osteosíntesis previamente colocado no resulta una escenario infrecuente a pesar de los reportes sobre mortalidad del 30 al 50 al año de los pacientes con fractura de cadera.</p><p>Ante dicha situación, hemos utilizado un clavo endomedular retrogrado asociado a la extracción de forma percutánea de los tornillos del implante previo.</p><p>Se presentan 8 casos de fracturas periosteosíntesis en pacientes con una edad promedio de 85.6 años, 5 femeninos y 8 masculinos con un tiempo desde la osteosíntesis de fémur proximal a la fractura periosteosíntesis de 3.5 años promedio. Se realizó un seguimiento de 36 meses y se ha evaluado la movilidad y el dolor postoperatorio consiguiendo una consolidación de la fractura en todos los casos.</p><p>Dicho procedimiento nos ha resultado una técnica eficaz, capaz de lograr una fijación estable sin agregar morbilidad debido a la posibilidad de solapar los dos implantes disminuyendo la potencial posibilidad de una nueva fractura interimplantes. </p>
Genetic structure of a Colombian cape gooseberry (Physalis peruviana L.) collection by means of microsatellite markers
Authors: Chacón S. María Isabel , Sánchez Yubelly del Pilar , Barrero M. Luz Stella 
Published: May 2016

The cape gooseberry (Physalis peruviana L.), a fruit species cultivated in the Andes, is one of the major fruit exports of Colombia. We hypothesized that the Andean cordilleras in Colombia play a role in structuring the genetic diversity of this crop. For addressing this hypothesis, a set of 85 Colombian cape gooseberry accessions from different departments and cordilleras was analyzed by means of 15 SSR markers. AMOVA, clustering and Bayesian analyses were applied. The results showed the presence of two major groups related to geography: one consisting of cultivated and non-cultivated accessions from the eastern Andes (Norte de Santander, Santander, Boyaca and Cundinamarca) and the other one consisting of cultivated and non-cultivated accessions from the central and western Andes (Antioquia, Caldas, Cauca and Nariño). The genetic relationships between the accessions suggested that the movement of cape gooseberry seeds may be more frequent between neighboring regions, thus explaining the existence of these two major groups. The results also showed lower levels of genetic diversity in this sample (HE=0.223), as compared to other Physalis species and other studies on the cape gooseberry that used different molecular markers. It is recommended that future evaluation studies include both cultivated and non-cultivated genotypes from the two major groups detected in this study in order to better represent the genetic diversity available in this crop.
Response of various oil palm materials (Elaeis guineensis and Elaeis oleifera × Elaeis guineensis interspecific hybrids) to bud rot disease in the southwestern oil palm-growing area of Colombia
Authors: Avila-Diazgranados Rodrigo Andrés , Daza Edison Steve , Navia Edwin , Romero Hernán Mauricio 
Published: May 2016

Palms planted in an area with a high bud rot disease (BR) inoculum pressure were evaluated monthly for a six-year period to determine their tolerance, resistance, or susceptibility to the disease. Dura-type E. guineensis and OxG (E. oleifera × E. guineensis) interspecific hybrids Coari × La Me were evaluated. Of the two types of genetic material evaluated, the progenies of the E. guineensis palms showed the highest levels of incidence, reaching 90% affected palms in less than two years of evaluation. Although the hybrids showed susceptibility, they had a lower degree of affectation than the dura-type palms. The severity assessment of both genetic materials showed that the dura-type palms had the highest degree of affectation, reaching the highest values after over two years of evaluation. However, the hybrids, which were not homogeneous in terms of the level of severity, did not exceed, on average, severity level 2. According to the scale, severity level 2 is indicative of tolerance to the disease.
Hirnbasissyndrom infolge eines Tumors bei einer 17 Monate alten Deutsch-Holstein-Färse
Authors: Schöniger Sandra , Gerlach Kerstin , Schusser Gerald Fritz , Köller Gabor , Starke Alexander , Wippermann Wolf 
Published: May 2016

ZusammenfassungEine 17 Monate alte Färse der Rasse Deutsch-Holstein wurde wegen seit einem Tag bestehender Schluckstörungen, geringgradiger Lähmung der Zunge sowie Lidschwellungen vorgestellt. Die klinische Untersuchung ergab eine gestreckte Kopf-Hals-Haltung, hochgradige Salivation, einen reduzierten Zungentonus sowie einen Schlotterkiefer mit vollständigem Ausfall des Schluckreflexes. Am rechten Auge zeigten sich ein herabhängend wirkendes Oberlid, mukopurulenter Ausfluss, Expositionskeratitis, Hornhauttrübung und Miosis. Linksseitig bestanden ein mittelgradiger Exophthalmus und geringgradiger muköser Nasenausfluss. Bei der neurologischen Untersuchung waren multiple Kopfnervenausfälle festzustellen, die für das Vorliegen eines Hirnbasissyndroms sprachen. Röntgenologisch ließ sich ventral des Siebbeins eine klar abgegrenzte, weichteildichte Verschattung von ca. 5 cm Durchmesser mit Verdacht auf intraneurokranialen Ursprung nachweisen, die sich rhinoskopisch mit unebener, geröteter, teils von eitrigem Exsudat bedeckter Oberfläche darstellte. Die pathomorphologische Untersuchung des euthanasierten Rindes bestätigte das Vorliegen einer Neoplasie, die von der Fossa hypophysialis des Corpus ossis basisphenoidalis bis in den Bereich ventral des Siebbeins reichte. Die histopathologischen Befunde passten zu einem sogenannten „kleinzelligen blauen Rundzelltumor“.
Integrating Pharmacogenomics into Clinical Practice
Authors: Johal Gurinder , Amlani Adam 
Published: May 2016

Pharmacogenomics has the potential to improve patient-centered care and lead to an overall decrease in healthcare costs. This would be achieved through fewer hospitalizations due to adverse drug reactions, individualized and effective therapies, and decreased drug development costs with single nucleotide polymorphism pre-screening. Although challenges do exist in encouraging the use of phar­macogenomics―specifically in regards to resources, regulation, and impacts on the pharmaceutical industry―the benefits may out­weigh the costs in terms of patient health and safety. In implementing pharmacogenomics, various clinical, ethical, legal, social and economical factors must be considered.

La pharmacogénomique aurait le potentiel de diminuer le coût des soins de santé et d’optimiser les soins primaires aux patients. Il serait possible d’y parvenir en réduisant les hospitalisations suite aux effets secondaires associés aux médicaments, en utilisant des thérapies individualisées plus efficaces et en diminuant le coût associé au développement de médicaments grâce au test de dépistage de polymorphisme d’un seul nucléotide. Malgré les défis associés à l’utilisation de la pharmacogénomique surtout sur le plan des ressources, de la régulation et de l’impact dans l’industrie pharmaceutique, les avantages en terme de santé et de sécurité sont à considérer. Plusieurs facteurs cliniques, éthiques, légaux, sociaux, et économiques doivent être pris en considération pour l’utilisation de la pharmacogénomique.
Метод реконфігурації керування літаком в умовах виникнення особливої ситуації в польоті
Authors: Shevchuk Dmitriy 
Published: May 2016

Виконано порівняльний аналіз статистичних даних ICAO. Показано, що 35 % випадків виникнення особливих ситуацій пов’язано з відмовами та пошкодженнями систем автоматичного керування, головним чином із відмовами приводів та пошкодженнями зовнішніх обводів і керуючих органів. Наведено класифікацію існуючих походів та методів створення реконфігурованих систем керування складними об’єктами в умовах виникнення особливих ситуацій. Розроблено метод реконфігурації для збереження стійкості та керованості літака в умовах виникнення особливих ситуацій у польоті, та запобігання її розвитку або переростання в катастрофічну.
Sociocultural Theory, the L2 Writing Process, and Google Drive: Strange Bedfellows?
Authors: Slavkov Nikolay 
Published: May 2016

This article draws on sociocultural theory and the process approach to writing as familiar and widely used elements of second language pedagogy that can be leveraged in interesting new ways through the use of digital technology. The focus is on a set of affordances offered by Google Drive, a popular online storage and document-sharing technology. On the assumption that dynamic collaboration with peers, teacher feedback, and authentic computer-mediated tasks contribute to the development of writing skills, Google Drive can be seen as an effective tool for meaningful and cost-effective technology-enriched instruction that entails po- tential advances in pedagogical practice. An overview of the app’s user-friendly interface is provided from a nonspecialist perspective, followed by a discussion of how one may go about organizing a writing course using the tool in a language lab or online. Specific examples of tasks used in ESL courses at a North American postsecondary institution are included. Cet article puise dans la théorie socioculturelle et l’approche à l’écriture par pro- cessus, des concepts bien connus et répandus en enseignement L2 et dont on peut tirer parti de façons innovatrices grâce à la technologie numérique. Notre étude porte sur les capacités de Google Drive, une technologie populaire qui permet le stockage en ligne et le partage de documents. Tenant comme acquis que la colla- boration dynamique avec les pairs, la rétroaction de la part des enseignants et les tâches authentiques assistées par ordinateur contribuent au développement des compétences en écriture, nous présentons Google Drive comme un outil tech- nologique efficace et rentable qui vient enrichir la pédagogie de l’enseignement authentique. Nous offrons un aperçu de l’interface conviviale de l’application du point de vue d’un non-spécialiste pour ensuite discuter de la façon d’organiser, dans un laboratoire d’informatique ou en ligne, un cours d’écriture avec Google Drive. Des exemples spécifiques de tâches employées dans des cours d’ALS dans une institution post-secondaire en Amérique du Nord sont présentés.
Evidence Linking the Role of Placental Expressions of Peroxisome Proliferator‐Activated Receptor‐γ and Nuclear Factor‐Kappa B in the Pathogenesis of Preeclampsia Associated With Periodontitis
Authors: Mahendra Jaideep , Parthiban Prathahini S. , Mahendra Little , Balakrishnan Anandan , Shanmugam Sambandham , Junaid Mohammed , Romanos Georgios E. 
Published: May 2016

Background: Peroxisome proliferator‐activated receptor (PPAR)‐γ activation leads to suppression of production of a broad range of proinflammatory molecules. It plays a role in differentiation of trophoblasts and helps in normal placentation and formation of vascular exchange interface. Activation of nuclear factor‐kappa (NF‐κ) B triggers proinflammatory molecules inducing abnormal placentation and premature labor. This study aims to explore expression of PPAR‐γ and NF‐κB in placentas of women with periodontitis‐associated preeclampsia compared with that in normotensive pregnant women.Methods: Fifty pregnant women were included. Twenty‐five were controls (normotensive pregnant women) and 25 were pregnant women with preeclampsia, including those with gestational hypertension. Demographic data, pregnancy characteristics, and periodontal parameters were recorded, including: 1) plaque index; 2) gingival index; 3) bleeding on probing (BOP); 4) probing depth; and 5) attachment loss (AL). Placental tissue samples were collected from both groups and analyzed to quantify expression of PPAR‐γ and NF‐κB using real‐time polymerase chain reaction.Results: BOP and AL were significantly higher in pregnant women with preeclampsia compared with normotensive pregnant women (P <0.05). Expression of PPAR‐γ was downregulated in patients with preeclampsia compared with that of healthy normotensive patients, which was statistically significant (P <0.05), whereas NF‐κB was significantly activated (P <0.05) in pregnant women with preeclampsia compared with normotensive pregnant women.Conclusions: Higher periodontal disease prevalence is found among pregnant women with preeclampsia, with increased percentage of sites with BOP and greater AL. This study provides novel information on host response to systemic inflammation induced by periodontal pathogens through mechanisms involving downregulation of PPAR‐γ and increased activation of NF‐κB.
Displasia cemento-óssea florida: relato de caso
Authors: Moreti Lucieni Cristina Trovati , Barbosa Pedro Augusto Caetano , Boer Nilton César Pezati , Fernandes Karina Gonzales Câmara , Ogata Mitsuru 
Published: May 2016

Lesões fibro-ósseas benignas são caracterizadas pela substituição do tecido ósseo normal por tecido conjuntivo fibroso celular com conteúdo calcificado variando distribuição e volume. A displasia cemento-óssea florida não tem etiologia definida, prevalecendo em mulheres negras de meia idade a idosas. Pode se expandir bilateralmente, mostra-se restrita aos maxilares e envolve a região periapical dos dentes com vitalidade pulpar. Na maioria dos casos a lesão é descoberta entre os 30 e 50 anos de idade durante exames radiográficos de rotina, pois geralmente é assintomática. O propósito deste trabalho é o relato de caso clínico de mulher negra de 40 anos de idade, que procurou a Clínica Odontológica da Universidade Camilo Castelo Branco (Unicastelo) - Campus de Fernandópolis, para tratamento endodôntico. Ao exame radiográfico inicial verificou-se lesão de aspecto misto na região de periápice do dente 46, mostrando calcificação densa, circunscrita, cercada por halo radiotransparente estreito e ausência de expansão da cortical óssea. A radiografia panorâmica mostrou imagem mista (radiolúcida com área radiopaca) bilateral, em ambas as arcadas, simétrica e não circunscrita. Os dentes se mostravam hígidos, sem aumento de volume na região e com vitalidade. Considerando a presença das lesões em ambas as arcadas, o diagnóstico inicial foi displasia cemento-óssea florida, sendo o mesmo ratificado por meio das características clínicas e radiográficas. Como tratamento nenhum procedimento cirúrgico foi adotado. Foi instituído o acompanhamento clínico e radiográfico. Ressalta-se com esse caso clínico a importância dos exames complementares por imagem no auxilio do diagnóstico das lesões fibro-ósseas que acometem a cavidade bucal e podem não apresentar sintomatologia.Descritores: Doenças de Desenvolvimento Ósseo; Diagnóstico por Imagem; Doenças Maxilomandibulares.
The Influence of Bi Rate to the Distribution of Working Capital Loans
Authors: Kurnianingrum Dian 
Published: May 2016

This research “The influence of BI rate to the distribution of working capital loans" is conducted at Indonesian commercial bank during the month of January 2005 until May 2009. The purpose of this research is to determine the effect of BI rate toward the distribution of working capital loans. To test the research hypotheses, the data were analyzed by using Pearson correlate and simple linear regression. Based on research, BI rate significantly influence the distribution of working capital loans. BI rate gives a negative impact to the distribution of working capital loans. It means, the increase in BI rate will decrease the distribution of working capital loans, and vice versa, the decrease in BI rate will increase the distribution of working capital loans.
Integrating a Smartphone–Based Self–Management System into Usual Care of Advanced CKD
Authors: Ong Stephanie W. , Jassal Sarbjit V. , Miller Judith A. , Porter Eveline C. , Cafazzo Joseph A. , Seto Emily , Thorpe Kevin E. , Logan Alexander G. 
Published: May 2016

Background and objectives
Patient self-management has been shown to improve health outcomes. We developed a smartphone-based system to boost self-care by patients with CKD and integrated its use into usual CKD care. We determined its acceptability and examined changes in several clinical parameters.

Design, setting, participants, & measurements
We recruited patients with stage 4 or 5 CKD attending outpatient renal clinics who responded to a general information newsletter about this 6-month proof-of-principle study. The smartphone application targeted four behavioral elements: monitoring BP, medication management, symptom assessment, and tracking laboratory results. Prebuilt customizable algorithms provided real–time personalized patient feedback and alerts to providers when predefined treatment thresholds were crossed or critical changes occurred. Those who died or started RRT within the first 2 months were replaced. Only participants followed for 6 months after recruitment were included in assessing changes in clinical measures.

Results
In total, 47 patients (26 men; mean age =59 years old; 33% were ≥65 years old) were enrolled; 60% had never used a smartphone. User adherence was high (>80% performed ≥80% of recommended assessments) and sustained. The mean reductions in home BP readings between baseline and exit were statistically significant (systolic BP, −3.4 mmHg; 95% confidence interval, −5.0 to −1.8 and diastolic BP, −2.1 mmHg; 95% confidence interval, −2.9 to −1.2); 27% with normal clinic BP readings had newly identified masked hypertension. One hundred twenty-seven medication discrepancies were identified; 59% were medication errors that required an intervention to prevent harm. In exit interviews, patients indicated feeling more confident and in control of their condition; clinicians perceived patients to be better informed and more engaged.

Conclusions
Integrating a smartphone–based self–management system into usual care of patients with advanced CKD proved feasible and acceptable, and it appeared to be clinically useful. The results provide a strong rationale for a randomized, controlled trial.
Traumatic lung injury attributed to tornadic activity–induced barometric pressure changes in two dogs
Authors: Cichocki Brandy N. , Dugat Danielle R. , Snider Timothy A. 
Published: May 2016

Abstract
CASE DESCRIPTION A 7-year-old castrated male Italian Greyhound (dog 1) and an approximately 1-year-old female Labrador Retriever (dog 2) were evaluated because of respiratory distress 8 and 10 days, respectively, after a tornado.
CLINICAL FINDINGS No obvious external injuries were identified auscultation revealed decreased bronchovesicular sounds in the affected hemithorax of both dogs. Clinicopathologic changes were mild, with evidence of inflammation in both dogs. Thoracic radiography of both dogs revealed pneumothorax and pleural effusion with effacement of the diaphragm; findings on CT included severe pulmonary atelectasis of affected lung lobes with normal bronchial tree configurtion and no evidence of diaphragmatic hernia.
TREATMENT AND OUTCOME Exploratory thoracotomy of both dogs confirmed CT findings Pulmonary parenchymal damage consistent with a large rupture was found in both patients. A large hematoma was adhered to the ruptured lung lobe of dog 1. Grossly affected lung tissue was removed; histologic examination revealed atelectasis, pulmonary fib osis, thrombosis, and minimal (dog 1) to marked (dog 2) inflammation Microbial culture of lung tissue yielded no growth for dog 1 and Streptococcus spp and Escherichia coli susceptible to amoxicillin-clavulanic acid for dog 2. Dog 1 had a recurrence of pneumothorax treated by drainage with a thoracostomy tube 1 month after surgery. Eighteen months after surgery, both dogs were reportedly doing well.
CLINICAL RELEVANCE Development of clinical signs after a tornado, together with clinical, diagnostic imaging, surgical, and histologic findings led to a presumptive diagnosis of pulmonary barotrauma for both dogs. Long-term outcome for these dogs, treated at a referral hospital, was good.