bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quality Of Life Of Women Living With HIV/AIDS
Authors: De Araújo Barboza Rossana , Monara Bezerra Ramos Thais , De Veras Danielly Cristiny , Braga do Rego Renata , Souza da Silva Cleidiana , Jerônimo Costa Marcos Antônio , Moreira Freire Maria Eliane , De Oliveira e Silva Ana Cristina , Silva Paulo Emanuel , Ferreira de Sousa Julianne Cristinne , Feitosa Ferreira Gabriela , Martins Simões Candeia Rozileide , Abreu Viana Yúllia , Holmes Ericka Silva 
Published: May 2017

Objectives: to evaluate the quality of lifeof women withHIV/AIDSin the Stateof Paraíba anddefine them asthe socio-demographicprofile.
Method: This was a descriptive, exploratory and quantitative study, conducted at the Hospital Clementino Fraga, had a population of 33 women with HIV / AIDS, using the form of interviews HATQoL, clinical and sociodemographic, data collection took place in July 2014 after approval of the CEP UFPB. Results and Discussion: There was concern domains with commitment of confidentiality, financial worry and sexual activity with a possible association with clinical and sociodemographic data obtained, most women: they are aged between 36-42 years acquired HIV through heterosexual sex, unmarried , have children (between 1-2), have low education (less than 9 years of schooling) and low income (up to two minimum wages). Conclusion: Therefore, it is necessary that the care of these women is conducted by interdisciplinary teams that promote integrated care, gazing beyond the individual needs, aspects related to their quality of life. In this perspective, the nurse plays a fundamental role in promoting quality of life.
Keywords: Quality of life. Women. HIV. AIDS. Nursing.
Elderly Women's Perception About Nursing Gynecological Consultation: A Comprehensive Analysis
Authors: Rosa Aline Furtado , Beck Gabriela Troyack , Rosas Ann Mary Machado Tinoco Feitosa , Tito Ingrid Fernandes , Ferreira Tatiana , Santiago Adriana Da Silva 
Published: May 2017

The Brazilian elderly population, that is, the population aged 60 or older according to the Elderly Estatute, has increased in recent decades, a phenomenon observed in Brazil and worldwide. This rapid growth represents a major political and social impact, reflecting the consequent rise in cost of health services because this is the population that most need this service.
Objective: To understand the meaning of Nursing Consultation for elderly women assisted at a School Clinic in Mountain Region-RJ-Brazil.
Method: The is a qualitative study of descriptive and exploratory nature supported by the theoretical and methodological framework of Alfred Schutz through sociological phenomenology. The study was approved by the Ethics and Research Committee of the Arthur Sá Earp Neto Faculty on April 11, 2015 under Opinion number 1.019361. We used phenomenological interview.
Results: We performed 19 interviews with elderly women aged 60-80 years. The responses provided the understanding of women's experiences during the nursing consultation. This study gave rise to three categories that revealed the intentionality of this social group when searching for the nursing consultation: "To be well assisted", "To have resolving power" and "To prevent health problems".
Conclusions: The found that the nursing consultation promotes the approximation between women and the nursing professionals, establishing bonds, presenting efficient and effective results to treatment and prevention, besides providing mutual learning.
Teratoma With Mediastinal Embryonic Carcinoma Concomiting Hystiocytic Sarcoma In The Bone Marrow
Authors: Oliveira Cristiano Claudino , De Faveri Julio , Domingues Maria Aparecida Custódio 
Published: May 2017

Background: Association of extragonadal germ cell tumors EGCT with haematological malignancies is rare with a very limited prognosis.
Methods and findings: We report a case of a man, 21 years old, with progressive dyspnea, chest pain, night sweats, generalized edema, hemoptysis, pancytopenia and increased serum levels of alpha-fetoprotein (AFP), beta-fraction of the hormone chorionic gonodotrophin (beta-HCG) and lactic dehydrogenase. Chest computed tomography described a mediastinum mass measuring 11.3 x 7.3 cm whose biopsy revealed malignant germ cell neoplasia expressing positivity for cytokeratin, CD30 and AFP, indicating an embryonal carcinoma with teratoma. Bone marrow biopsy revealed interstitial infiltration by malignant neoplastic cells positive for CD68, CD163 and lysozyme, allowing the diagnosis of histiocytic sarcoma. The patient had a poor evolution, with death, sixteen days after admission.
Conclusion: Histiocytic proliferations are very rare and rapidly fatal. Etiopathogenic theories for the simultaneity of these malignancies have been described based on processes of transformation from a same cellular precursor.
Evaluation of Oral Hygiene in Patients with Visual Disabilities
Authors: Pinho Roberto Carlos Mourão , Santiago Leogenes Maia , Almeida Renata , Vajgel Bruna Carvalho , Cimões Renata 
Published: May 2017

Introduction: Patients with visual impairment present greater difficulty in achieving adequate oral hygiene due to restricted eyesight. Therefore, oral hygiene motivation and instruction methods should be adapted to these patients to understand the importance of bacterial plaque control, both for the health of dental tissues and periodontal tissues
Objective: The objective of the present study was to compare the plaque index (PI) of patients with and without visual impairment before and after the institution of oral hygiene instructions through a Randomized Clinical Trial. Twenty patients with visual impairment (Group 1) from the Instituto dos Cegos and 20 without visual impairment (Group 2) from the ASCES Periodontia Clinic were selected. Data were collected through the IP of O'Leary and reevaluated every 21 days for four sessions.
Results: in both groups, the mean of PI decreased with the time of evaluation, with a significant difference between the evaluations (p <0.001). Group 1 had a mean PI higher than group 2 only in the fourth evaluation, but there was no significant difference (p> 0.05). As for the mean of the PI assessments, group 2 presented a mean higher than group 1, but without significant difference (p> 0.05).
Conclusion: The study therefore suggests that there is no difference in PI in patients with or without visual impairment, and that the guidelines stimulate and motivate an improvement in oral hygiene conditions.
Les Lyonnais et saint Bonaventure (fin du XV e -XVIII e siècles)
Authors: Henryot Fabienne 
Published: May 2017

C’est au couvent des cordeliers de Lyon que Bonaventure est mort en 1274. Deux siècles plus tard, à la suite de sa canonisation prononcée en 1482, sa dépouille est convoquée dans une série de discours et de pratiques autant politiques que religieux, visant à légitimer des pouvoirs superposés. Le pouvoir royal d’abord, au tournant des xv	e  et xvi	e  siècles, s’empare de la relique pour s’imposer à Lyon. Puis ce sont les institutions municipales qui l’instrumentalisent pour créer et rendre visible un ordre civique et moral harmonieux et cohérent, particulièrement au xvii	e  siècle. Enfin, les franciscains lyonnais tentent de récupérer la relique pour consolider leur unité mise à mal par un siècle de dissensions internes. La relique de saint Bonaventure est ainsi un exemple manifeste de l’usage politique et social des reliques dans la France urbaine moderne, favorisant l’union, la réconciliation et la territorialisation de l’espace urbain.
Disease-Specific Effects of Matrix and Growth Factors on Adhesion and Migration of Rheumatoid Synovial Fibroblasts
Authors: Lefèvre Stephanie , Schwarz Maria , Meier Florian M. P. , Zimmermann-Geller Birgit , Tarner Ingo H. , Rickert Markus , Steinmeyer Jürgen , Sauerbier Michael , Rehart Stefan , Müller-Ladner Ulf , Neumann Elena 
Published: May 2017

Abstract
In rheumatoid arthritis (RA), cartilage and bone matrix are degraded, and extracellular matrix (ECM) proteins, acting as cellular activators, are liberated. Similar to ECM proteins, matrix-bound chemokines, cytokines, and growth factors (GFs) influence functional properties of key cells in RA, especially synovial fibroblasts. The role of these molecules on attachment, migration, and proinflammatory and prodestructive activation of RASFs was analyzed. Adhesion/migration of RASFs were examined under GF-enriched (GF+) or –reduced (GF−) conditions with or without addition of matrix-associated GFs, TGF-β, and platelet-derived GF to GF− or culture supernatants. Fibroblast adhesion and alterations in proinflammatory/prodestructive properties (e.g., IL-6/matrix metalloproteinase 3-release) in response to matrix-associated molecules were compared. Effects of GF+, GF−, and other ECM components on human RASF-mediated cartilage invasion were examined in the SCID mouse model. RASF adhesion under GF− conditions was significantly lower compared with GF+ conditions (6.8- versus 8.3-fold). This effect was specific for RA because control cells showed opposite effects (e.g., osteoarthritis synovial fibroblasts [SF]; GF− versus GF+: 10.7- versus 8-fold). Addition of TGF-β to GF− increased RASF attachment (12.7-fold) compared with other matrices and components. RASF adhesion to GF+ matrix resulted in the strongest IL-6 and matrix metalloproteinase-3 release, and was even more pronounced compared with supplementation of single GFs. In vivo, GF− matrix decreased RASF-mediated cartilage invasion compared with GF+ matrix. ECM components and especially GFs when bound within ECM actively enhance RASF attraction and cartilage adhesion. This observation was specific for RASFs as a reverse behavior was observed for controls.
B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection
Authors: Kosaraju Rasagna , Guesdon William , Crouch Miranda J. , Teague Heather L. , Sullivan E. Madison , Karlsson Erik A. , Schultz-Cherry Stacey , Gowdy Kymberly , Bridges Lance C. , Reese Lauren R. , Neufer P. Darrell , Armstrong Michael , Reisdorph Nichole , Milner J. Justin , Beck Melinda , Shaikh Saame Raza 
Published: May 2017

Abstract
Obesity is associated with increased risk for infections and poor responses to vaccinations, which may be due to compromised B cell function. However, there is limited information about the influence of obesity on B cell function and underlying factors that modulate B cell responses. Therefore, we studied B cell cytokine secretion and/or Ab production across obesity models. In obese humans, B cell IL-6 secretion was lowered and IgM levels were elevated upon ex vivo anti-BCR/TLR9 stimulation. In murine obesity induced by a high fat diet, ex vivo IgM and IgG were elevated with unstimulated B cells. Furthermore, the high fat diet lowered bone marrow B cell frequency accompanied by diminished transcripts of early lymphoid commitment markers. Murine B cell responses were subsequently investigated upon influenza A/Puerto Rico/8/34 infection using a Western diet model in the absence or presence of docosahexaenoic acid (DHA). DHA, an essential fatty acid with immunomodulatory properties, was tested because its plasma levels are lowered in obesity. Relative to controls, mice consuming the Western diet had diminished Ab titers whereas the Western diet plus DHA improved titers. Mechanistically, DHA did not directly target B cells to elevate Ab levels. Instead, DHA increased the concentration of the downstream specialized proresolving lipid mediators (SPMs) 14-hydroxydocosahexaenoic acid, 17-hydroxydocosahexaenoic acid, and protectin DX. All three SPMs were found to be effective in elevating murine Ab levels upon influenza infection. Collectively, the results demonstrate that B cell responses are impaired across human and mouse obesity models and show that essential fatty acid status is a factor influencing humoral immunity, potentially through an SPM-mediated mechanism.
A Time- and Compartment-Specific Activation of Lung Macrophages in Hypoxic Pulmonary Hypertension
Authors: Pugliese Steven C. , Kumar Sushil , Janssen William J. , Graham Brian B. , Frid Maria G. , Riddle Suzette R. , El Kasmi Karim C. , Stenmark Kurt R. 
Published: May 2017

Abstract
Studies in various animal models suggest an important role for pulmonary macrophages in the pathogenesis of pulmonary hypertension (PH). Yet, the molecular mechanisms characterizing the functional macrophage phenotype relative to time and pulmonary localization and compartmentalization remain largely unknown. In this study, we used a hypoxic murine model of PH in combination with FACS to quantify and isolate lung macrophages from two compartments over time and characterize their programing via RNA sequencing approaches. In response to hypoxia, we found an early increase in macrophage number that was restricted to the interstitial/perivascular compartment, without recruitment of macrophages to the alveolar compartment or changes in the number of resident alveolar macrophages. Principal component analysis demonstrated significant differences in overall gene expression between alveolar and interstitial macrophages (IMs) at baseline and after 4 and 14 d hypoxic exposure. Alveolar macrophages at both day 4 and 14 and IMs at day 4 shared a conserved hypoxia program characterized by mitochondrial dysfunction, proinflammatory gene activation, and mTORC1 signaling, whereas IMs at day 14 demonstrated a unique anti-inflammatory/proreparative programming state. We conclude that the pathogenesis of vascular remodeling in hypoxic PH involves an early compartment-independent activation of lung macrophages toward a conserved hypoxia program, with the development of compartment-specific programs later in the course of the disease. Thus, harnessing time- and compartment-specific differences in lung macrophage polarization needs to be considered in the therapeutic targeting of macrophages in hypoxic PH and potentially other inflammatory lung diseases.
FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+ T Cells
Authors: Chauhan Anil K. 
Published: May 2017

Abstract
Recognition of Ab-opsonized pathogens by immune cells triggers both TLR and Fc receptor signaling. Fc receptors endocytose modified nucleic acids bound to Abs and deliver them to endosomes, where they are recognized by nucleic acid–sensing TLRs (NA-TLRs). We show that in CD4+ T cells, NA-TLRs, TLR3, TLR8, and TLR9 are upregulated by FcγRIIIa-pSyk cosignaling and localize with FcγRIIIa on the cell surface. TLR9 accumulates on the cell surface, where it recognizes CpG oligonucleotide 2006. Subcellular location of NA-TLRs is a key determinant in discriminating self versus viral nucleic acid. Hydroxychloroquine used for treating systemic lupus erythematosus and a Syk inhibitor blocked NA-TLR localization with FcγRIIIa. Engaging TLR9 with CpG oligonucleotide contributes to the development of IL17A+ and IL-21+ populations. RNA-sequencing analysis showed upregulation of proinflammatory cytokines, NF-κB signaling, and heat shock protein pathway RNA transcripts. These data suggest a role for FcγRIIIa-pSyk cosignaling in modulating NA-TLR responses in human CD4+ T cells by affecting the amounts and cellular distribution. These events are important for understanding of autoimmune pathology.
The Upregulation of Integrin αDβ2 (CD11d/CD18) on Inflammatory Macrophages Promotes Macrophage Retention in Vascular Lesions and Development of Atherosclerosis
Authors: Aziz Moammir H. , Cui Kui , Das Mitali , Brown Kathleen E. , Ardell Christopher L. , Febbraio Maria , Pluskota Elzbieta , Han Juying , Wu Huaizhu , Ballantyne Christie M. , Smith Jonathan D. , Cathcart Martha K. , Yakubenko Valentin P. 
Published: May 2017

Abstract
Macrophage accumulation is a critical step during development of chronic inflammation, initiating progression of many devastating diseases. Leukocyte-specific integrin αDβ2 (CD11d/CD18) is dramatically upregulated on macrophages at inflammatory sites. Previously we found that CD11d overexpression on cell surfaces inhibits in vitro cell migration due to excessive adhesion. In this study, we have investigated how inflammation-mediated CD11d upregulation contributes to macrophage retention at inflammatory sites during atherogenesis. Atherosclerosis was evaluated in CD11d−/−/ApoE−/− mice after 16 wk on a Western diet. CD11d deficiency led to a marked reduction in lipid deposition in aortas and isolated macrophages. Macrophage numbers in aortic sinuses of CD11d−/− mice were reduced without affecting their apoptosis and proliferation. Adoptive transfer of fluorescently labeled wild-type and CD11d−/− monocytes into ApoE−/− mice demonstrated similar recruitment from circulation, but reduced accumulation of CD11d−/− macrophages within the aortas. Furthermore, CD11d expression was significantly upregulated on macrophages in atherosclerotic lesions and M1 macrophages in vitro. Interestingly, expression of the related ligand-sharing integrin CD11b was not altered. This difference defines their distinct roles in the regulation of macrophage migration. CD11d-deficient M1 macrophages demonstrated improved migration in a three-dimensional fibrin matrix and during resolution of peritoneal inflammation, whereas migration of CD11b−/− M1 macrophages was not affected. These results prove the contribution of high densities of CD11d to macrophage arrest during atherogenesis. Because high expression of CD11d was detected in several inflammation-dependent diseases, we suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development.
Assessment of Oral and Dental Health Status in Children with Cerebral Palsy: An Exploratory Study
Authors: Sedky Nabila Ahmed 
Published: May 2017

ABSTRACTObjectivesEvaluating oral and dental health status in Egyptian children with cerebral palsy (CP) in relation to gross motor skills and types of CP.Materials and methodsCross-sectional study was conducted at el-Shatby Hospital for Children, Alexandria, Egypt. Oral examination for 62 children with CP between the age range 3 and 12 years was performed, and decayed, missing, and filled permanent teeth (DMFT)/decayed and filled primary teeth (dft), simplified oral hygiene index (OHI-S), and modified gingival index (MGI) were charted. Maxillofacial defects, dental problems, and drooling of saliva were assessed. Children's CP type, motor milestone, and gross motor skills were determined. All statistical analyses were carried out at p<0.05 and 0.01.ResultsAbout 84.0% of children had spastic quadriplegia, 41.9% were sit-supported, 32.3% had level IV Gross Motor Function Classification System (GMFCS), 29.0% had level V no maxillofacial defects, 14.5% had dentin exposure greater than one-third of the surface, and 22.6% had frequent/severe drooling saliva. Caries prevalence comprised 54.8%, 53.2% had poor oral hygiene (OHI-S), and 43.6% had severe gingival inflammation (MGI). The first best predictor variable for dft was “motor milestone” The GMFCS (levels IV and V) was the first best predictor variable for DMFT, OHI-S, and MGI.ConclusionThe majority of children had dental caries, poor oral hygiene, and severe gingival inflammation. Children who were sit-supported, had no neck support, and stand-supported were suffering from dental caries (dft) more than children who were sitting and walking alone. Children with levels IV/V GMFCS were prone to have dental caries (DMFT), susceptible to suffer from bad oral hygiene, and older children experiencing severe gingivitis more than younger ones.How to cite this articleSedky NA. Assessment of Oral and Dental Health Status in Children with Cerebral Palsy: An Exploratory Study. J Contemp Dent 2017;7(1):1-11.
A Comparative Evaluation of the Marginal and Internal Fit of Laboratory-fabricated Monolithic Zirconia Crowns using Direct and Indirect Methods of Scanning: An in vitro Study
Authors: Gandhi Kushal N 
Published: May 2017

ABSTRACTAimTo evaluate the marginal and internal fit of laboratoryfabricated monolithic zirconia crowns using direct and indirect methods of scanning.Materials and methodsA stainless steel master model was selected, which included stainless steel die, outer cap, and inner cap. The study was divided into two groups. In group I, direct method of scanning was carried out in which the stainless steel die was scanned directly with chairside scanner, and in group II, impression of the stainless steel die was made and gypsum die was fabricated, which was then subjected to scanning. Zirconia blanks or blocks were milled, sintered, and polished to obtain 10 zirconia crowns of each group. Replica technique was used to evaluate fit of crowns by using light body as cement analog. The crowns were then sectioned, viewed under a stereomicroscope, and each predetermined region was measured and evaluated for marginal and internal fit.ResultsThe descriptive statistics showed that the mean marginal fit for indirect method was higher compared with that for direct method. The results of paired-sample t-test revealed that mean marginal and internal fit for indirect method was on the upper side of the scale, whereas the mean for the direct method is on the lower side of the scale. Thus, the difference in the means of two methods was quite large and likely to be significant.ConclusionThe results did show better marginal and internal fit in crowns fabricated by the direct method; however, the crowns fabricated by the indirect method had more discrepancy, but were in the clinically acceptable limit.Clinical significanceThe present study would serve as a useful guide in deciding which method of scanning would give a better marginal and internal fit of monolithic zirconia crowns for longevity of restorations.How to cite this articleGandhi KN, Ram SM. A Comparative Evaluation of the Marginal and Internal Fit of Laboratory-fabricated Monolithic Zirconia Crowns using Direct and Indirect Methods of Scanning: Anin vitroStudy. J Contemp Dent 2017;7(1):22-27.
Comparative Evaluation of the Depth of Penetration of different Types of Desensitizing Agents into the Dentinal Tubules: An in vivo Study
Authors: Mitra Aditya , Adhikari Chandrani 
Published: May 2017

ABSTRACTAimAim of the study is to evaluate the depth of penetration of different types of desensitizing agents into the dentinal tubules in vivo.Materials and methodsTwenty patients requiring tooth extraction for orthodontic purpose were selected. In all four premolars of the selected patients, small class V cavities were prepared on the buccal surface having depth of 0.5 mm. They were divided into four groups and treated with four different types of desensitizing agents (5% NaF solution, Gluma desensitizer, FluorProtector, and SuperSeal) for required time and then they were extracted. They were longitudinally sectioned and each section was studied by scanning electron microscope.ResultsThe mean depth of penetration of SuperSeal and Gluma was significantly higher than that of other agents (sodium fluoride and FluorProtector) (p<0.05). No significant difference was found between SuperSeal and Gluma (p>0.05).ConclusionThe depth of penetration of resinous desensitizing agent (Gluma) is maximum followed by potassium oxalate solution (SuperSeal) and fluoride varnish (FluorProtector).Clinical significanceDeeper the penetration of desensitizing agents into the dentinal tubules, longer the efficacy.How to cite this articleMitra A, Adhikari C. Comparative Evaluation of the Depth of Penetration of different Types of Desensitizing Agents into the Dentinal Tubules: An in vivo Study. J Contemp Dent 2017;7(1):43-47.