bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genre and Style Metamorphoses of German Choral Cantata of 18th-19th Centuries
Authors: Liu Shanshan 
Published: October 2024

The purpose of the work is to reveal the genre-stylistic and spiritual-content instructions of the German choral cantata and the peculiarities of its existence in the musical-historical tradition of the 18th-19th centuries. The methodology of the work has a complex nature and is based on a combination of the principles of interdisciplinary, historical-typological, hermeneutic, art history and genre-stylistic research methods. The scientific novelty of the work lies in the fact that, for the first time, it offers a generalisation of the poetic-intonational specificity of the German spiritual cantata of the 18th-19th centuries and its genre-stylistic metamorphoses in the specified period. Conclusions. The genre specificity of the German spiritual cantata is determined by its contact with the liturgical practice of the German Protestant church. This genre is directly related to the church sermon and therefore was called "sermon music", "motet", "concert", "dialogue", summarised by the concept of Hauptmusik ("Main music of the day"). The contact of the German spiritual cantata with its Italian analogues and opera did not exclude the presence of original features in it, among which the Protestant chorale, based on traditional for the 18th-19th centuries, dominates. polyphonic forms, on the significant role of the instrumental beginning. An essential feature of the genre can be considered its figurative and semantic focus on the reproduction of the sacred aspects of a person's life path, their spiritual ascent-transformation, interpreted in the context of the instructions of the Lutheran faith. The German romantic cantata, represented in the works of R. Schumann, F. Mendelssohn, R. Wagner, and J. Brahms, on the one hand, reflected a wide genre and style spectrum of the creative searches of the named authors, within the framework of which the cantata was synthesised with the typology of various genres – from chamber a vocal cycle, a leader's play up to an oratorio, a dramatic scene (in the works of R. Schuman). On the other hand, the romantics' appeal to the poetics of the choral cantata symbolised the revival of the German spiritual and musical tradition, summarised by the name of J. S. Bach, which was directly reproduced in the cantata compositions of F. Mendelssohn, R. Wagner ("The Brotherly Meal of the Apostles") and works of Y. Brahms. Despite all the differences in the textual basis of the works of the named authors and their aesthetic guidelines (Y. V. Goethe, M. Horn, T. Moore, paraphrases of biblical texts), their unifying quality is the "memory of the genre", focused on the reproduction of the individual's spiritual path and the high didactic and ethical meaning of their inner transformation.
Resistance of spring durum wheat varieties to stem rust on the background of natural infection
Authors: Serikbaykyzy A. , Rsaliev Sh. S. , Temirbekova S. K. 
Published: October 2024

The scientific study presents the results and indicators of the cultivation of spring durum wheat in the world, the main varieties of spring durum wheat in the south-east of Kazakhstan, the development of stem rust on durum wheat varieties (Triticum durum Desf.), data on the stability of varieties in grain-bearing regions of the republic. Field experiments were conducted in the conditions of the foothill zone of the Almaty region in 2022. The object of research was 15 varieties of spring durum wheat of various origins: Gordeiforme 254, Nauryz 2, Nauryz 6, Seymour 17, Milana, Salauat, Zhakut 20 (Kazakh Research Institute of Agriculture and Plant Growing), Altyn dala, Asangali 20, Sharifa (Karabalyk Agricultural Station), Damsinskaya jubileinaya (A.I. Barayev Research and Production Centre for Grain Farming), Bezenchukskaya 182, Kanysh (Russia), Berillo (Italy), Kamillaroi (Australia).Under natural conditions, the manifestation of stem rust (Puccinia graminis f. sp. tritici) on spring durum wheat varieties was late, in the phase of flowering and filling of plant grains. In the experience, many varieties of Kazakh and foreign breeding have shown moderate resistance and susceptibility to the disease. In the varieties Salauat and Zhakut 20, the initial and subsequent development of the disease did not exceed 20%, which is a sign of Slow rust development. With a strong lesion of the Nauryz 2 variety (60%), Gordeyforme 254, Milana, Nauryz 6, Damsinskaya jubileinaya, Altyn Dala, Asangali 20, Berillo and Kamillaroi were moderately susceptible. The Seymour 17, Sharifa and Kanysh varieties showed moderate resistance to stem rust.
The influence of the method of processing rapeseed seeds on their protein complex
Authors: Minevich I. E. , Ushchapovsky V. I. , Yakovleva A. A. , Zaitseva L. A. 
Published: October 2024

Relevance. The recycling of secondary rapeseed raw materials is a perspective trend for increasing the efficiency of production of this agricultural crop.Methods. Degreasing of the rapeseed kernel fraction was carried out by hexane extraction, wateralcohol treatment of the low—fat rapeseed kernel with a mixture of water + ethanol (3:7). The fractional composition of the rapeseed protein complex was determined by sequential extraction with distilled water, 7% NaCl solution and 0.1M NaOH solution. Protein isolation: extractant — NaCl solution (70 g/l), pH — 9.0, T — 50 °С, duration — 90 min. The protein was precipitated at pH 4.8 and dried in a microwave oven at 500 W for 3–4 minutes. Absorption spectra of protein fractions of rapeseed seeds were recorded on a PE-5400 UV spectrophotometer using the SC5400 program.Results. It was shown that degreasing by hexane extraction contributed to an increase in the content of globulins (by 8.5%) with a decrease in albumins (by 3.0%) and glutelins (by 3.3%). Analysis of the UV spectra of these protein fractions showed the presence of synaptic acid in the fractions of albumins and globulins. The water-alcohol treatment of the skimmed rapeseed kernel, carried out to remove phenolic compounds, contributed to the partial removal of protein from the raw material (protein content decreased from 39.06 to 32.34%), limited protein denaturation, which leads to a decrease in protein solubility and protein yield in the extract, as indicated by a decrease in the yield of the protein product relative to the raw material from 26.4 to 15.3%, a decrease in protein yield relative to the protein contained in the raw material, from 28.9 to 20.3%.
Systemic effect of the oncological process on the dog’s body
Authors: Vilmis D. A. , Melikova J. N. , Chechneva A. V. 
Published: October 2024

The article presents the results of an analysis of a non-randomized study of the prevalence of paraneoplastic syndromes in primary spontaneous malignant neoplasms in dogs. The study was conducted in 2022–2024 on the basis of the Department of Diseases of Small Domestic, Laboratory and Exotic Animals and the Research Laboratory of Oncology, Ophthalmology and Animal Biochemistry of the Russian Biotechnological University “ROSBIOTECH”. The object of the study were 948 dogs with primary spontaneous malignant neoplasms confirmed by morphological methods.The aim of the work was to study the frequency of paraneoplastic syndromes in dogs with neoplasia.The diagnosis of paraneoplastic syndrome was made by excluding other possible etiological factors for the development of clinical and laboratory abnormalities identified during a comprehensive examination of dogs. As a result of the study, the incidence of paraneoplasia was 54.54% of cases. Hematological (44.41%) and gastrointestinal (37.13%) paraneoplastic syndromes were most often recorded, less often endocrine (3.27%) and ophthalmological (3.38%), extremely rarely renal (1.27%), osteoarticular (0.42%) and dermatological (0.42%). The main hematological manifestations of the systemic effect of the oncological process were: anemia (12.87%), neutrophilic leukocytosis (12.76%) and thrombocytopenia (8.86%). Gastrointestinal paraneoplastic syndrome in most cases was manifested by a decrease in body weight (33.65%) and hyporexia (18.04%), inflammatory and erosive ulcerative lesions of the gastrointestinal tract (7.59%). During the study, a case of a nonspecific systemic reaction to a malignant tumor in the form of fever in the absence of infectious and inflammatory processes (0.11%) was registered.
Changes in milk productivity and quality of goat milk when including cake and probiotic in the diet
Authors: Kislova D. A. , Sheida E. V. , Kvan O. V. , Duskaev G. K. 
Published: October 2024

Relevance. One of the solutions to reduce food waste is to try to get the most out of food waste and byproducts. The experiment assessed the milk productivity and milk quality of lactating Nigerian goat goats when using hemp cake on the background of a probiotic substance.Methodology. The research was carried out in 2 stages: in the 1st experiment, the effect on the digestibility of nutritional components of feed was studied as a result of the inclusion of waste from the fat and oil industry in the diet of goats in the amount of 5% hemp (QL) cake, in the 2nd experiment, the enzymatic probiotic drug “Cellobacterin+” (“Biotrof” LLC) was additionally included in the experimental group at a dosage of 10 g/goal /day.Results. According to the research results, it was found that the inclusion of hemp cake in the diet of lactating goat goats did not have a negative effect on milk yield and milk quality, and contributed to a reduction in the cost of its production. The additional introduction of the probiotic drug “Cellobacterin+” into the diet contributed to an increase in milk yield in goats, in the conditions of the Southern Urals, and improved the chemical composition of milk, in particular, increased fat and protein content.
Pleurotus ostreatus is a potential biological control agent of root-knot nematodes in eggplant (Solanum melongena)
Authors: Nyangwire Betty , Ocimati Walter , Tazuba Anthony Fredrick , Blomme Guy , Alumai Alfred , Onyilo Francis 
Published: October 2024

IntroductionThe management of root-knot nematodes has predominantly been based on use of chemicals, which are detrimental to the environment and human health. Biological control provides alternative management. This study evaluated the potential of using Pleurotus ostreatus, an edible mushroom species to control Meloidogyne spp. in eggplants.MethodsIn vitro, the mortality of juveniles (J2) of Meloidogyne spp. were assessed i) P. ostreatus - water suspension with actively growing mycelia, and ii) different dilutions of P. ostreatus PDB broth culture filtrates. In the screen house nematicidal potential of P. ostreatus was tested on eggplants using artificially inoculated soils in a screen house. To attain this, juveniles (J2) of Meloidogyne spp. were inoculated at the base of plants in pots containing P. ostreatus colonized millet grains mixed in 3 kg of soil. The galling index (GI) (scale of 0 to 5), root growth and nematode populations in the different treatments were assessed.Results and discussionMortality of nematodes in the P. ostreatus - water suspension significantly increased with time, reaching over 88% at 48 h and 95% at 72 h. Mortality in undiluted filtrate was consistently significantly higher than the diluted filtrates and control without P. ostreatus. Mortality in the undiluted filtrate increased to 95% at 48 h. When 50 g of P. ostreatus-millet culture was mixed with 3 kg autoclaved pot soil, a GI of 0.95 was observed, dropping to 0.70 when the inoculum was doubled to 100 g. For the treatment without P. ostreatus, a high GI of 2.4 was scored. A significant difference in eggplant root growth and nematode population at (p = 0.02) was found across the treatments. The findings from this study for both in-vitro and pot assay suggest that P. ostreatus and its substrate are potential biological control agents for plant parasitic nematodes in eggplants.
Altered expression of long noncoding RNAs regulating neutrophilic inflammation in peripheral blood was associated with symptom severity in patients with house dust mite-induced allergic rhinitis
Authors: Zhao Jinming , Pu Xiaoyu , Wang Xiangdong , Zhang Luo 
Published: October 2024

BackgroundLong noncoding RNAs (lncRNAs) have been implicated in a diverse array of human immune diseases; however, a comprehensive understanding of the expression and function of lncRNAs in the peripheral blood leukocytes of individuals suffering from house dust mite (HDM)-induced allergic rhinitis (AR) remains elusive.ObjectiveTo explore the potential roles and functions of long noncoding RNAs (lncRNAs) in the pathogenesis of AR.MethodsSequencing analysis was performed on peripheral blood leukocytes collected from patients with HDM-induced AR and healthy controls (HCs) to elucidate the expression patterns of lncRNAs. Differentially expressed (DE) lncRNAs were identified and validated, and further correlation analyses were conducted to explore their associations with visual analog scale (VAS) scores and cytokine levels in the serum and nasal secretions. Additionally, bioinformatics analyses were performed to predict the potential pathways influenced by DE lncRNAs. Finally, the diagnostic potential of these lncRNAs in AR was assessed via receiver operating characteristic (ROC) curve analysis.ResultsSignificant differences in the expression profiles of lncRNAs and mRNAs were detected between AR patients and HCs. Four lncRNAs were markedly upregulated in AR patients. AC011524.2 was positively correlated with nasal pruritus (r = 0.4492, P = 0.0411). AL133371.3 was positively correlated with runny nose (r = 0.4889, P = 0.0245). AC011524.2 was positively correlated with CXCL8 (r = 0.4504, P = 0.0035). AL133371.3 was significantly positively correlated with only IL-17 (r = 0.4028, P = 0.0100). IL-4 in the serum was positively related to IL-17 in the serum (r = 0.4163, P = 0.0002). CXCL5 in the serum was positively correlated with IFN-γ (r = 0.3336, P = 0.0354) in nasal secretions. The area under the curve (AUC) of the ROC curve resulting from the integration of the 4 lncRNAs exhibited a remarkable value of 0.940 for AR diagnosis.ConclusionsOur results identified several lncRNAs associated with AR symptoms and inflammatory cytokines. Specifically, AC011524.2 and AL133371.3 exhibited strong correlations with diverse AR manifestations and serum cytokines, suggesting their pivotal role in the pathogenesis of AR, likely via neutrophil- and Th17-related pathways. However, the precise underlying mechanisms are still elusive, necessitating further exploration.
Radiation protection and natural building materials in cultural heritage
Authors: La Verde Giuseppe , Ricciardelli Alessio , Ognibene Elisa , Ambrosino Fabrizio , Pugliese Mariagabriella 
Published: October 2024

IntroductionBuildings that constitute cultural heritage and that are the identity of a defined geographical area are increasingly being restored to offer the community historical places to enjoy. Often the restoration preserves the original structure and building materials, which are usually natural stones. In this study, a radioprotection protocol dedicated to this kind of built environment was proposed and validated.MethodsAfter identifying the two predominant types of building material stones (Rosso ammonitico and Pietra Serena), radiometric measurements for natural gamma-emitting radionuclides (Ra-226, Th-232, and K-40) and measurements of the emanation coefficient and calculation of the exhalation rate of radon gas were carried out.ResultsThe two types of stone have a content of natural radionuclides that do not exceed the levels recommended by the regulations. The difference between the two types of stone is of an order of magnitude indicating that the red ammonite has a greater radiological impact than the pietra serena.DiscussionThe results, in addition to ensuring the radioprotection of the population, highlighted the need to increase the number of this kind of investigations to implement scientific knowledge and serve the stakeholders involved.
Protamine 2 deficiency results in Septin 12 abnormalities
Authors: Sanovec Ondrej , Frolikova Michaela , Kraus Veronika , Vondrakova Jana , Qasemi Maryam , Spevakova Daniela , Simonik Ondrej , Moritz Lindsay , Caswell Drew Lewis , Liska Frantisek , Ded Lukas , Cerny Jiri , Avidor-Reiss Tomer , Hammoud Saher Sue , Schorle Hubert , Postlerova Pavla , Steger Klaus , Komrskova Katerina 
Published: October 2024

There is a well-established link between abnormal sperm chromatin states and poor motility, however, how these two processes are interdependent is unknown. Here, we identified a possible mechanistic insight by showing that Protamine 2, a nuclear DNA packaging protein in sperm, directly interacts with cytoskeletal protein Septin 12, which is associated with sperm motility. Septin 12 has several isoforms, and we show, that in the Prm2−/− sperm, the short one (Mw 36 kDa) is mis-localized, while two long isoforms (Mw 40 and 41 kDa) are unexpectedly lost in Prm2−/− sperm chromatin-bound protein fractions. Septin 12 co-immunoprecipitated with Protamine 2 in the testicular cell lysate of WT mice and with Lamin B1/2/3 in co-transfected HEK cells despite we did not observe changes in Lamin B2/B3 proteins or SUN4 expression in Prm2−/− testes. Furthermore, the Prm2−/− sperm have on average a smaller sperm nucleus and aberrant acrosome biogenesis. In humans, patients with low sperm motility (asthenozoospermia) have imbalanced histone–protamine 1/2 ratio, modified levels of cytoskeletal proteins and we detected retained Septin 12 isoforms (Mw 40 and 41 kDa) in the sperm membrane, chromatin-bound and tubulin/mitochondria protein fractions. In conclusion, our findings present potential interaction between Septin 12 and Protamine 2 or Lamin B2/3 and describe a new connection between their expression and localization, contributing likely to low sperm motility and morphological abnormalities.
Characterizing adipocytokine-related signatures for prognosis prediction in prostate cancer
Authors: Fan Shicheng , Liu Haolin , Hou Jian , Zheng Guiying , Gu Peng , Liu Xiaodong 
Published: October 2024

BackgroundProstate cancer (PCa) is a prevalent malignant tumor in males, with a significant incidence of biochemical recurrence (BCR) despite advancements in treatment. Adipose tissue surrounding the prostate, known as periprostatic adipose tissue (PPAT), contributes to PCa invasion through adipocytokine production. However, the relationship between adipocytokine-related genes and PCa prognosis remains understudied. This study was conducted to provide a theoretical basis and serve as a reference for the use of adipocytokine-related genes as prognostic markers in PCa.MethodsTranscriptome and survival data of PCa patients from The Cancer Genome Atlas (TCGA) database were analyzed. Differential gene expression analysis was conducted using the DESeq2 and limma packages. Prognostic genes were identified through univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression. A prognostic model was developed and validated utilizing receiver operating characteristic (ROC) and Kaplan-Meier (K-M) curves. Assessments of immune cell infiltration and drug sensitivity were also carried out. Subsequently, the function of BNIP3L gene in PCa was verified.ResultsA total of 47 adipocytokine-related differentially expressed genes (DEGs) were identified. Five genes (PPARGC1A, APOE, BNIP3L, STEAP4, and C1QTNF3) were selected as prognostic markers. The prognostic model demonstrated significant predictive accuracy in both training and validation cohorts. Patients with higher risk scores exhibited poorer survival outcomes. Immune cell infiltration analysis revealed that the high-risk group had increased immune and ESTIMATE scores, while the low-risk group had higher tumor purity. In vitro experiments confirmed the suppressive effects of BNIP3L on PCa cell proliferation, migration, and invasion.ConclusionThe prognostic model independently predicts the survival of patients with PCa, aiding in prognostic prediction and therapeutic efficacy. It expands the study of adipocytokine-related genes in PCa, presenting novel targets for treatment.
Discovering the effectiveness of climate finance for Somalia’s climate initiatives: a dual-modeling approach with multiple regression and support vector machine
Authors: Nor Mohamed Ibrahim , Mussa Mohamed Barre 
Published: October 2024

IntroductionThis research investigates into the complex dynamics of climate finance in Somalia, a vulnerable region facing the dire consequences of climate change. The study aims to assess how financial inputs for climate-related projects align with the actual needs and identify critical factors that influence funding effectiveness.MethodsA dual-methodological approach was employed, integrating both multiple regression analysis and Support Vector Machine (SVM) techniques. This mixed-method analysis facilitates a robust examination of climate finance data to dissect the relationships and impacts of various determinants on funding effectiveness.ResultsThe results indicate that adaptation finance, robust governance, and the scale of financial interventions significantly enhance the effectiveness of climate finance flows. However, mitigation finance and aspects related to gender equality displayed less significant impacts. Notably, the study identifies a pervasive underfinancing of climate projects in Somalia, illustrating a significant gap between the needed and actual funds disbursed.DiscussionThe findings underscore the need for enhanced governance frameworks and targeted large-scale financial interventions to optimize the allocation and impact of climate finance in vulnerable regions like Somalia. By quantifying the influence of adaptation finance and governance, this study contributes new insights to the literature on climate finance effectiveness and suggests practical strategies for policymakers and practitioners to improve climate resilience initiatives.
2D speckle tracking echocardiography and comparison with cardiac magnetic resonance in children with acute myocarditis
Authors: Burešová M. , Pavlíček J. , Hanzlíková P. , Tomášková H. , Rybníček O. 
Published: October 2024

BackgroundCardiac magnetic resonance (CMR) plays a major diagnostic role in acute myocarditis (AM) in children as biopsy is rarely performed in this age group. Contribution of standard echocardiography (ECHO) is limited in AM, but speckle tracking echocardiography (STE) quantitatively characterizes myocardial function, with good sensitivity for detecting subclinical left ventricular (LV) dysfunction and regional kinetics disorders beyond the site of inflammation. This work aimed to evaluate the diagnostic potential of STE as compared with CMR findings in pediatric patients with AM.MethodsThe study was conducted during 2022–2023. Troponin, electrocardiography, ECHO with STE, and CMR with early and late enhancement were performed on each patient. Affected heart segments were analyzed by both STE and CMR, and the correlation of the two methods was assessed.ResultsDuring the study period, 20 children were diagnosed with AM [14 boys, 6 girls; mean age 12 years (median 14)]. On ECHO, three patients had a deviation in LV biometry, and four patients had a mild systolic function disorder. STE showed at least one affected cardiac segment in all patients, most often the inferolateral segment (16/20; 80%). Of the 20 patients, STE showed a reduction in LV global longitudinal strain in 13 (65%) patients. In all patients, CMR identified an inflammatory focus, most frequently inferolateral (15/20; 75%). The strongest accordance between STE and CMR was observed for the involvement of anterolateral segments (k = 0.88) and the weakest for inferoseptal damage (k = 0.4).ConclusionsSTE can provide important diagnostic information in pediatric patients with AM. This modality supports the detection of early regional edema and subclinical myocardial dysfunction and can determine the impairment severity. STE is non-invasive and repeatable without the need for special patient preparation or for general anesthesia.