bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid Nanoparticle–Mediated Delivery of Anti-miR-17 Family Oligonucleotide Suppresses Hepatocellular Carcinoma Growth
Authors: Huang Xinqiang , Magnus Jill , Kaimal Vivek , Karmali Priya , Li Jian , Walls Marlena , Prudente Rene , Sung Eric , Sorourian Mehran , Lee Robin , Davis Scott , Yang Xia , Estrella Heather , Lee Edmund C. , Chau B. Nelson , Pavlicek Adam , Zabludoff Sonya 
Published: February 2017

Abstract
Hepatocellular carcinoma (HCC) is one of the most common human malignancies with poor prognosis and urgent unmet medical need. Aberrant expression of multiple members of the miR-17 family are frequently observed in HCC, and their overexpression promotes tumorigenic properties of HCC cells. However, whether pharmacologic inhibition of the miR-17 family inhibits HCC growth remains unknown. In this study, we validated that the miR-17 family was upregulated in a subset of HCC tumors and cell lines and its inhibition by a tough decoy inhibitor suppressed the growth of Hep3B and HepG2 cells, which overexpress the miR-17 family. Furthermore, inhibition of the miR-17 family led to a global derepression of direct targets of the family in all three HCC cell lines tested. Pathway analysis of the deregulated genes indicated that the genes associated with TGFβ signaling pathway were highly enriched in Hep3B and HepG2 cells. A miR-17 family target gene signature was established and used to identify RL01-17(5), a lipid nanoparticle encapsulating a potent anti-miR-17 family oligonucleotide. To address whether pharmacologic modulation of the miR-17 family can inhibit HCC growth, RL01-17(5) was systemically administrated to orthotopic Hep3B xenografts. Suppression of Hep3B tumor growth in vivo was observed and tumor growth inhibition correlated with induction of miR-17 family target genes. Together, this study provides proof-of-concept for targeting the miR-17 family in HCC therapy. Mol Cancer Ther; 16(5); 905–13. ©2017 AACR.
When Blue-Collars Feel Blue
Authors: Lemogne Cédric , Meneton Pierre , Wiernik Emmanuel , Quesnot Ariane , Consoli Silla M. , Ducimetière Pierre , Nabi Hermann , Empana Jean-Philippe , Hoertel Nicolas , Limosin Frédéric , Goldberg Marcel , Zins Marie 
Published: February 2017

Background—
The association of psychological variables with cardiovascular health might depend on socioeconomic status. We examined the moderating effect of occupational grade on the association between depression and incident cardiac events among middle-aged workers from the GAZEL cohort.

Methods and Results—

A total of 10 541 participants (7855 men, mean age: 47.8±3.5 years) free of cardiovascular diseases completed the Center of Epidemiologic Studies Depression scale in 1993. Age, sex, and occupational grade (low, medium, and high) were obtained from company records. Classical cardiovascular risk factors were self-reported. All participants were followed-up for medically certified cardiac events from January 1994 to December 2014. Associations between baseline variables and incident cardiac events were estimated with hazard ratios and 95% confidence intervals computed in Cox regressions. After a median follow-up of 21 years, 592 (5.6%) participants had a cardiac event. There was a significant interaction between depression and occupational grade in both age- and sex-adjusted (
P
=0.008) and multiadjusted (
P
=0.009) models. This interaction was mainly explained by an association between depression and incident cardiac events that prevailed among participants of low occupational grade (3.71 versus 1.96 events per 1000 person-years among those depressed versus nondepressed, multiadjusted hazard ratios [95% confidence intervals], 1.99 [1.12–3.48]).

Conclusions—
From a research perspective, these results may account for previous conflicting results and constitute an impetus for reanalyzing previous data sets, taking into account the moderating role of socioeconomic status. From a clinical perspective, they urge clinicians and policy makers to consider depressive symptoms and low socioeconomic status as synergistic cardiovascular risk factors.
Diagnostic Performance of Narrow Band Imaging for Laryngeal Cancer: A Systematic Review and Meta‐analysis
Authors: Sun Changling , Han Xue , Li Xiaoying , Zhang Yayun , Du Xiaodong 
Published: February 2017

ObjectiveTo evaluate the performance of narrow band imaging (NBI) for the diagnosis of laryngeal cancer and to compare the diagnostic value of NBI with that of white light endoscopy.Data SourcesPubMed, Embase, Cochrane Library, and CNKI databases.Review MethodsData analyses were performed with Meta‐DiSc. The updated Quality Assessment of Diagnostic Accuracy Studies–2 tool was used to assess study quality and potential bias. Publication bias was assessed with the Deeks’s asymmetry test. The protocol used in this article has been published on PROSPERO and is in accordance with the PRISMA checklist. The registry number for this study is CRD42015025866.ResultsSix studies including 716 lesions were included in this meta‐analysis. The pooled sensitivity, specificity, and diagnostic odds ratio for the NBI diagnosis of laryngeal cancer were 0.94 (95% confidence interval [95% CI]: 0.91‐0.96), 0.89 (95% CI: 0.85‐0.92), and 142.12 (95% CI: 46.42‐435.15), respectively, and the area under receiver operating characteristics curve was 0.97. Among the 6 studies, 3 evaluated the diagnostic value of white light endoscopy, with a sensitivity of 0.81 (95% CI: 0.76‐0.86), a specificity of 0.92 (95% CI: 0.88‐0.95), and a diagnostic odds ratio of 33.82 (95% CI: 14.76‐77.49). The evaluation of heterogeneity, calculated per the diagnostic odds ratio, gave an I2 of 66%. No marked publication bias (P =. 84) was detected in this meta‐analysis.ConclusionThe sensitivity of NBI is superior to white light endoscopy, and the potential value of NBI needs to be validated in future studies.
Chronicity of Voice‐Related Health Care Utilization in the General Medicine Community
Authors: Cohen Seth M. , Lee Hui‐Jie , Roy Nelson , Misono Stephanie 
Published: February 2017

ObjectivesTo examine voice‐related health care utilization of patients in the general medical community without otolaryngology evaluation and explore factors associated with prolonged voice‐related health care.Study DesignRetrospective cohort analysis.SettingLarge, national administrative US claims database.Subjects and MethodsPatients with voice disorders perInternational Classification of Diseases, Ninth Revision, Clinical Modification(ICD‐9‐CM) codes from January 1, 2010, to December 31, 2012, seen by a general medical physician, and who did not see an otolaryngologist in the subsequent year were included. Voice‐related health care utilization, patient demographics, comorbid conditions, and index laryngeal diagnosis were collected. Logistic regression with variable selection was performed to evaluate the association between predictors and ≥30 days of voice‐related health care use.ResultsIn total, 46,205 unique voice‐disordered patients met inclusion criteria. Of these patients, 8.5%, 10.0%, and 12.5% had voice‐related health care use of ≥90, ≥60, and ≥30 days, respectively. Of the ≥30‐day subset, 80.3% and 68.5%, respectively, had ≥60 and ≥90 days of voice‐related health care utilization. The ≥30‐day subset had more general medicine and nonotolaryngology specialty physician visits, more prescriptions and procedures, and 4 times the voice‐related health care costs compared with those in the <30‐day subset. Age, sex, employment status, initial voice disorder diagnosis, and comorbid conditions were related to ≥30 days of voice‐related health care utilization.ConclusionsThirty days of nonotolaryngology‐based care for a voice disorder may represent a threshold beyond which patients are more likely to experience prolonged voice‐related health care utilization. Specific factors were associated with extended voice‐related health care.
A Qualitative Study of Challenges and Opportunities in Mobilizing Research Knowledge on Violence Against Women
Authors: Sibbald Shannon L. , MacGregor Jennifer C. D. , MacMillan Harriet L. , Wathen Nadine 
Published: February 2017

Background Effective delivery of interventions by health and social services requires research-based knowledge which identifies the causes and consequences of violence against women. Methods to effectively share new knowledge with violence against women decision-makers remain under studied. Purpose This paper examines how new research-based knowledge—namely, the lack of efficacy of health-care screening for exposure to intimate partner violence against women—is received by stakeholders in the violence against women field. Methods Data from 10 stakeholder group discussions ( N = 86) conducted during a knowledge-sharing forum were analyzed to assess how stakeholders responded to the new knowledge. Results Participant reactions ranged from full acceptance to significant resistance to the research findings. We suggest themes that help explain these reactions, including the context and content of our findings and their epistemological match to participants’ experiences and beliefs, and the perceived value of research evidence, compared to other forms of knowledge. Conclusions Violence against women is a complex psycho-social phenomenon, and people with an interest in this field bring diverse and even conflicting perspectives regarding its causes, consequences, and potential solutions.
Compliance with the faecal calprotectin test in patients with inflammatory bowel disease
Authors: Maréchal Chloé , Aimone‐Gastin Isabelle , Baumann Cédric , Dirrenberger Bastien , Guéant Jean‐Louis , Peyrin‐Biroulet Laurent 
Published: February 2017

BackgroundWe investigated, for the first time, levels of compliance with faecal calprotectin test in inflammatory bowel disease patients.MethodsAll consecutive adult inflammatory bowel disease patients having been prescribed an faecal calprotectin test between December 2014–July 2015 were included. At their next visit to the hospital, patients had to return a stool sample for the faecal calprotectin test and answer a simple questionnaire: ‘Have you brought a stool sample? If not, why not? If so, did you encounter any difficulties when collecting the sample? Were you aware of faecal calprotectin before being asked to take the test?'.ResultsOne hundred and one patients were included (50 men; 77 patients with Crohn’s disease). The range age was 40 years (19–68). Eighty‐nine patients were being treated with infliximab, 10 were on vedolizumab, and two were not being treated with a biologic. Thirty‐seven patients (35%) had performed the faecal calprotectin test. Eighty‐one patients (80%) had not been aware of faecal calprotectin before being asked to take the test. Of the 64 patients who did not take the test, the prime reasons for non‐compliance were forgetfulness (n  = 49, 76.6%), a lack of perceived benefit for the test (n  = 7, 11%), constipation (n  = 5, 7.8%), refusal to handle faeces (n  = 2, 3.1%), and difficulty collecting the stool sample (n  = 1, 1.5%).ConclusionOnly one‐third of the patients performed the faecal calprotectin test. The main reason for non‐compliance was forgetfulness. Our present results emphasise the need for better patient education on the importance of complying with faecal calprotectin testing and the future of faecal calprotectin testing at home.
Transaction processing in consistency-aware user’s applications deployed on NoSQL databases
Authors: González-Aparicio María Teresa , Ogunyadeka Adewole , Younas Muhammad , Tuya Javier , Casado Rubén 
Published: February 2017

AbstractNoSQL databases are capable of storing and processing big data which is characterized by various properties such as volume, variety and velocity. Such databases are used in a variety of user applications that need large volume of data which is highly available and efficiently accessible. But they do not enforce or require strong data consistency nor do they support transactions. This paper investigates into the transaction processing in consistency-aware applications hosted on MongoDB and Riak which are two representatives of Document and Key-Value NoSQL databases, respectively. It develops new transaction schemes in order to provide NoSQL databases with transactional facilities as well as to analyze the effects of transactions on data consistency and efficiency in user’s applications. The proposed schemes are evaluated using the YCSB + T benchmark which is based on Yahoo! Cloud Services Benchmark (YCSB). Experimental results show that using the proposed schemes, strong consistency can be achieved in MongoDB and Riak without severely affecting their efficiency. We also conduct experiments in order to analyse the level of consistencyof MongoDB and Riak transactional systems.
El Inventario de Estrategias de Autorregulación: traducción al español, características psicométricas preliminares y su relación con variables sociodemográficas en una muestra de estudiantes universitarios
Authors: Monge López David , Bonilla Roger , Aguilar-Freyan Wendy 
Published: February 2017

Esta investigación presenta la traducción al español del Inventario de Estrategias de Autorregulación. El constructo de aprendizaje autorregulado posee importancia como potencial predictor del logro académico. En este trabajo se abordaron estudiantes universitarios y se evaluó el autoinforme de autorregulación al aprendizaje de modo general, con el objetivo de poseer una línea base acerca de la percepción de ellos del proceso en cuestión. El instrumento se aplicó a una muestra de 282 estudiantes. El análisis factorial exploratorio dio como resultado tres dimensiones, las cuales se encuentran también en la investigación antecedente. La medición posee buena fiabilidad, y tanto las dimensiones del instrumento como la medición general de aprendizaje autorregulado correlacionaron con una medida independiente de autorregulación. Con un objetivo exploratorio, se relacionaron la medición de aprendizaje autorregulado con una serie de variables sociodemográficas. Se encontraron asociaciones de diferentes dimensiones del aprendizaje autorregulado con el sexo y el tipo de estructura familiar del estudiante. La calidad del instrumento indica que puede ser utilizado para la investigación sobre el tema. Los resultados obtenidos con respecto al sexo y al tipo de familia deben ser replicados por otros estudios con muestras y métodos similares
Quality of perinatal data capture by nurses in Osun State, Nigeria
Authors: Komolafe Abiola , Irinoye Omolola , Hanson Victoria 
Published: February 2017

Background: The quality of information that nurses capture in the perinatal period contributes to efficiency in clinical decision making for improved maternal and child outcome. Aims: This study explored the quality of perinatal data capture by nurses in Osun State, Nigeria. Methods: A descriptive design was adopted and multistage sampling technique was used to select 427 nurses from perinatal units across three levels of care. Data were collected using a pre-tested questionnaire and checklists and analysis was done with SPSS version 16. Findings: There was no uniformity in data capture in the study setting. Respondents were not aware of the concept of the national perinatal dataset and the quality of perinatal data capture was poor at all levels of care. Conclusions: Perinatal data capture by nurses was not standardised across the three levels of care and the captured data were inadequate and of poor quality.
Certified midwives' experiences of mentorship and supervision during internship in Lusaka, Zambia
Authors: Mwiinga Betty Miyanda , Maimbolwa Margaret C , Muleya Mutinta C 
Published: February 2017

Background: Mentorship is a programme aimed at preparing midwives to cement their knowledge and skills in order to provide quality services at all levels of the health-care delivery system. Understanding the experiences of those who undergo mentorship is important to improve the programme. Aims: The main purpose of this study was to explore certified midwives' experiences of the mentorship and supervision received during internship at the University Teaching Hospital, Lusaka, Zambia. Methods: A qualitative phenomenological study was used to elicit the experiences of the certified midwives who had taken part in an internship during their training. A total of 13 participants were purposively included in the study and In-depth interviews using an unstructured interview schedule were conducted and recorded. Content analysis using Nvivo software version 10 was used to analyse data following transcription of the recorded interview. Results: Five major themes emerged from the interview data: clinical environment; the relationship that existed between mentors and mentees/ward staff; availability of human and material resources; mentors' knowledge, attitude and skills regarding mentorship and supervision; and lessons learned. Conclusions: The results of this study show that certified midwives were not satisfied with the mentorship and supervision received during internship. Their experiences included instances of uncaring attitudes from the qualified staff, inadequate equipment and staffing, inadequate clinical supervision, non-availability of mentors in the wards and the labelling of certified midwives. It can therefore be concluded that there are still some gaps that need to be reviewed by the policy makers in order for the programme to be beneficial.
Discordance between Circulating Atherogenic Cholesterol Mass and Lipoprotein Particle Concentration in Relation to Future Coronary Events in Women
Authors: Lawler Patrick R , Akinkuolie Akintunde O , Ridker Paul M , Sniderman Allan D , Buring Julie E , Glynn Robert J , Chasman Daniel I , Mora Samia 
Published: February 2017

Abstract

BACKGROUND
It is uncertain whether measurement of circulating total atherogenic lipoprotein particle cholesterol mass [non–HDL cholesterol (nonHDLc)] or particle concentration [apolipoprotein B (apo B) and LDL particle concentration (LDLp)] more accurately reflects risk of incident coronary heart disease (CHD). We evaluated CHD risk among women in whom these markers where discordant.

METHODS
Among 27533 initially healthy women in the Women's Health Study (NCT00000479), using residuals from linear regression models, we compared risk among women with higher or lower observed particle concentration relative to nonHDLc (highest and lowest residual quartiles, respectively) to individuals with agreement between markers (middle quartiles) using Cox proportional hazards models.

RESULTS
Although all 3 biomarkers were correlated (r ≥ 0.77), discordance occurred in up to 20.2% of women. Women with discordant high particle concentration were more likely to have metabolic syndrome (MetS) and diabetes (both P &lt; 0.001). Over a median follow-up of 20.4 years, 1246 CHD events occurred (514725 person-years). Women with high particle concentration relative to nonHDLc had increased CHD risk: age-adjusted hazard ratio (95% CI) = 1.77 (1.56–2.00) for apo B and 1.70 (1.50–1.92) for LDLp. After adjustment for clinical risk factors including MetS, these risks attenuated to 1.22 (1.07–1.39) for apo B and 1.13 (0.99–1.29) for LDLp. Discordant low apo B or LDLp relative to nonHDLc was not associated with lower risk.

CONCLUSIONS
Discordance between atherogenic particle cholesterol mass and particle concentration occurs in a sizeable proportion of apparently healthy women and should be suspected clinically among women with cardiometabolic traits. In such women, direct measurement of lipoprotein particle concentration might better inform CHD risk assessment.
Requiem for the long tail: Towards a political economy of content aggregation and fragmentation
Authors: Napoli Philip M. 
Published: February 2017

Abstract
This article revisits the long tail phenomenon, a dozen years after it was first articulated as a model for the digital media economy. As this article illustrates, both the research evidence and the evolution of industry practice have demonstrated that the long tail phenomenon has failed to take hold to the extent expected. This article outlines the interconnected technological, institutional and economic factors that explain the decline of the long tail, and considers the implications of this decline for media policy and media research.
Book Reviews
Authors: Krieken Robert van , Amado Adriana , Finkelstein David 
Published: February 2017

Abstract
PRESUMED INTIMACY: PARA-SOCIAL RELATIONSHIPS IN MEDIA, SOCIETY AND CELEBRITY CULTURE, CHRIS ROJEK (2015) 1st ed., Malden, MA: Polity, 224 pp., ISBN: 9780745671109, p/bk, $69.95 ISBN: 9780745671116, $24.95, e-book, $19.99
POLITICAL COMMUNICATION AND LEADERSHIP: MIMETIZATION, HUGO CHAVEZ AND THE CONSTRUCTION OF POWER AND IDENTITY, ELENA BLOCK (2015) 1st ed., London: Routledge, 284 pp., ISBN: 9781138905030, h/bk, $102.24, e-book, $54.95
MAGAZINES AND THE MAKING OF AMERICA: MODERNIZATION, COMMUNITY AND PRINT CULTURE, 1741–1860, HEATHER HAVEMAN (2015) 1st ed., Princeton: Princeton University Press, 432 pp., ISBN: 9780691164403, h/bk, $45.00, ISBN: 9781400873883, e-book, $27.79
The triumph of the Puppet: the Victory of Death is a Blow to Life. The Movement of Life and Death in the Opus of Silvan Omerzu.
Authors: Kovše Tea 
Published: February 2017

Abstract
The puppets of Silvan Omerzu problematise life by staging death. In his 20 years of making puppet shows for adults, the puppet has travelled from the grotesque image, rapid movement and playful violence to the ascetic minimalistic world, both in its image and its movement. Omerzu’s latest show, Salto mortale, depicts the immortality of puppets. This complex puppet world can be described by Das Unheimliche, which best captures the staging of death no matter whether it is carried out in a playful, mysterious or anxious atmosphere. Silvan Omerzu’s puppets show the victory of death or the victory of puppets over death, thus staging our captivity within life.
“Hello World”
Authors: Drori Amit 
Published: February 2017

Abstract
Israeli artist and theatre maker Amit Drori reflects on the creative process that led him to create robotic-based performances. This was not an organized plan but rather an artistic evolution that began during his studies at the School of Visual Theatre in Jerusalem, and developed in his work as a professional artist. Coming from a background of visual theatre and puppetry, Drori’s approach to robotics uses the knowledge and philosophy of puppetry and animation forms. Drori creates unique machines that are designed for emotional and poetic functionalities. “Hello world” follows the personal process of his artistic development, but also tries to discern the cultural roots and transformations of the accessibility of knowledge in the open source revolution.
Oil content and fatty acids composition of poppy seeds cultivated in two localities of Slovakia
Authors: Lančaričová Andrea , Havrlentová Michaela , Muchová Darina , Bednárová Adriána 
Published: February 2017

Abstract
Oil content, fatty acids profile, acid and saponification values of poppy seeds grown on two localities of the Slovak Republic were evaluated in the study. Statistically significant effects of locality, genotype and their interaction (P < 0.05) for numerous descriptors were proved by non-parametric tests. Results confirmed that variation in the analysed parameters was influenced by the colour of seeds. Ochre variety Redy contained the highest oil level in both localities (49.9 and 52.4%) and linoleic acid level (74.3 and 71.6%). White-seeded Racek and Albín had the highest acid value (2.8 and 2.4% of free fatty acids) and grey-seeded Malsar and blue-seeded Maratón contained the highest saponification value. Buddha, a high-morphine poppy variety, differed significantly in all monitored parameters. High negative interrelation between linoleic and oleic acids levels was observed. Oil content was positively correlated with linoleic acid and negatively with oleic acid. Weather conditions at the end of vegetation influenced the accumulation of oil and essential linoleic acid.