bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compact system for onsite calibration of 1000 kV voltage transformers
Authors: Zhao Shuangshuang , Huang Qifeng , Lei Min 
Published: December 2017

This study describes the development and evaluation of a compact system for onsite calibration of 1000 kV voltage transformers in ultra‐high‐voltage (UHV) AC power transmission projects. The proposed compact system consists of a 1000 kV electromagnetic voltage transformer as a standard, a high‐voltage resonant power supply, and a voltage transformer test set, which are assembled and mounted on a calibration truck. The developed system accuracy is 0.05% in ratio and 0.058 mrad in phase angle, respectively. Also, the total basic uncertainty is about ±0.028% and ±0.03 mrad under field conditions. The compact system can be automatically set up and taken down quickly on site requiring no substation cranes or utility operating crews. It has successfully undergone complete field tests and calibrated 63 1000 kV voltage transformers in total at 5 UHV substations. The feasibility of an automatic and efficient approach to calibrating UHV voltage transformers on site has been demonstrated.
Linear demagnetizing strategy of DFIG‐based WTs for improving LVRT responses
Authors: Chang Yuanzhu , Kong Xiangping 
Published: December 2017

As doubly fed induction generator (DFIG)‐based wind turbines (WTs) have already become a significant power source in modern power systems, its dynamic performance under grid fault is ordered strictly by low‐voltage ride through (LVRT) grid codes, namely maintain grid‐connected and inject required current rapidly. In this study, LVRT responses of DFIG‐based WT, with different LVRT solutions, are analysed and evaluated by natural flux and its corresponding transient recovery period of control ability. Compared to exponential damping characteristics under traditional schemes, linear demagnetising strategy is proposed to realise the optimal damping characteristic in natural flux by making the most of current capacity in rotor‐side converter. As a result, LVRT responses are improved effectively, namely transient recovery time and oscillation of required current are decreased, to meet future grid codes. Finally, the superiority of proposed strategy is verified with an insulated gate bipolar transistor‐detailed simulation on a general electric (GE) 1.5 MW WT.
Kikuchi–Fujimoto's Disease in a Pediatric Patient with Mycobacterium tuberculosis Infection
Authors: Alali Muayad , Schulte Jefree J. , Hendrickson Barbara A. 
Published: December 2017

AbstractKikuchi–Fujimoto's disease (KFD), alternatively termed histiocytic necrotizing lymphadenitis, was first described in 1972. KFD is rare in children, with most of the cases occurring between the ages of 20 and 30 years with a female-to-male ratio of 4:1. The etiology is unknown, although infectious and autoimmune mechanisms have been proposed. KFD manifests with a spectrum of nonspecific clinical symptoms and laboratory findings. KFD is without a definitive diagnostic test and is a diagnosis of exclusion, which must be differentiated from other disease processes with associated lymphadenopathy. Significant overlap in both clinical presentation and histological features with other diseases, such as non-Hodgkin lymphoma, systemic lupus erythematosus, and active tuberculosis (TB), presents challenges in diagnosis. A small number of case reports have been published describing the coexistence of KFD and active TB. Most reported cases occur in TB endemic areas. In the largest analysis of KFD, TB infection was concurrent in 2% of cases. Most of the cases occurred in adult patients. To our knowledge, there have been no pediatric cases of KFD with concurrent TB infection reported in the United States. This study describes a case of KFD with concurrent Mycobacterium tuberculosis infection in a young male from the United States.
Operieren während der Schwangerschaft – Regelungen und Bedarfe
Authors: Fritze-Büttner Frauke , Dittmar Ronny , Niethard Maya 
Published: December 2017

ZusammenfassungAufgrund der deutlichen Zunahme von Frauen in der Medizin gewinnen berufspolitische Diskussionen zur Gleichstellung von Ärztinnen immer mehr Beachtung. Eine Thematik ist dabei das „Operieren in der Schwangerschaft“. Durch die bislang geltende Gesetzgebung und föderale Regelung war es schwangeren Chirurginnen bislang kaum möglich, ihre operative Tätigkeit fortzusetzen. Nach der Zustimmung des Bundesrats soll das reformierte Mutterschutzgesetz zum 01.01.2018 in Kraft treten. Es soll für Ärztinnen zukünftig dadurch leichter sein, auch in der Schwangerschaft zu operieren. Im Vordergrund steht dabei die Umgestaltung des Arbeitsplatzes anhand individueller Gefährdungsbeurteilungen unter Mitsprache der Frau, sodass ein risikoadaptiertes Operieren ermöglicht wird und vorzeitige Beschäftigungsverbote gegen den Wunsch der Schwangeren verhindert werden.
Wie beeinflusst der Diabetes mellitus das frühpostoperative und onkochirurgische Langzeit-„Outcome“ beim Rektumkarzinom?
Authors: Gebauer Björn , Meyer Frank , Ptok Henry , Steinert Ralf , Otto Ronny , Lippert Hans , Gastinger Ingo 
Published: December 2017

Zusammenfassung
Einleitung Ziel war es, den Einfluss von Diabetes mellitus (DM) auf das frühpostoperative und langfristige „Outcome“ nach operativer Intervention beim Rektumkarzinom anhand prospektiv-multizentrisch gewonnener Daten einer repräsentativen Patientenzahl zu untersuchen.
Methode Es wurden Daten der Qualitätssicherungsstudie „Rektum-Karzinom (Primärtumor) – Elektiv-Operation“ der Jahre 2008 – 2011 herangezogen, die über einen Erfassungsbogen mit 68 Items dokumentiert wurden. Über ein freiwilliges und regelmäßiges „Follow-up“ wurden Langzeitdaten eruiert. Unterteilt wurde in Patienten ohne DM und solche mit nicht- bzw. insulinpflichtigem DM (NIDDM bzw. IDDM).
Ergebnisse Insgesamt wurden 10 442 Patienten eingeschlossen, zu 11,0 % NIDDM- und zu 7,2 % IDDM-Patienten. Patienten ohne DM waren mit durchschnittlich 67,3 (95 %-KI: 67,07; 67,55) Jahren jünger als IDDM- mit 71,7 (95 %-KI: 71,01; 72,35) Jahren oder NIDDM-Patienten mit 70,9 (95 %-KI: 70,41; 71,45) Jahren (p < 0,001). Die UICC-Tumorstadien waren vergleichbar (p = 0,547). Diabetiker zeigten häufiger kardiovaskuläre/renale Risikofaktoren sowie Adipositas und hatten eine höhere ASA-Klassifikation (je p < 0,001). Die postoperative Morbidität (in der Altersgruppe 65 – 74 Jahre; p = 0,006) und Krankenhaus-Sterblichkeit (< 65 Jahre; p = 0,011) war beim Vorliegen eines DM erhöht. Das 5-Jahres-„Overall-Survival“ (OS) betrug bei Nicht-Diabetikern 60,6 %. IDDM (46,4 %) und NIDDM (53,3 %) bedingten ein schlechteres OS (je p < 0,001). Das 5-Jahres-„Disease-free survival“ (DFS) war ebenfalls bei IDDM (p < 0,001) und NIDDM (p = 0,004) vermindert. Für die 5-Jahres-Lokalrezidivrate wurden bei IDDM (p = 0,524) und NIDDM (p = 0,058) keine signifikanten Einflüsse gefunden.
Diskussion Die metabolische Störung DM stellt wahrscheinlich neben dem patienteneigenen Risikopotenzial durch die Kombination der vergesellschafteten Komorbiditäten einen relevanten Einflussfaktor auf das „Outcome“ nach Rektumkarzinom-Chirurgie dar. Die postoperative Morbidität und Letalität werden erhöht, das onkochirurgische Überleben verringert.
Antibacterial Effect of 2R,3R-dihydromyricetin on the Cellular Functions of Staphylococcus aureus
Authors: Wu Yan-Ping , Bai Jin-Rong , Zhong Kai , Bai Ding-Ding , Huang Yi-Na , Xiao Kai , Ran Yun , Gao Hong 
Published: December 2017

Abstract
The C-3-OH, C-4 carbonyl oxygen and hydrogenation of C2=C3 bond on the C-ring of 2R,3R-dihydromyricetin (DMY) proved to be not necessary for the antibacterial activity against Staphylococcus aureus. DMY significantly decreased the intracellular ATP of S. aureus cells but had few effects on pHin, proline oxidation, succinate dehydrogenase activity or malate dehydrogenase activity.
Meibomian Gland Performance in Glaucomatous Patients With Long-term Instillation of IOP-lowering Medications
Authors: Cho Wan-Hua , Lai Ing-Chou , Fang Po-Chiung , Chien Chun-Chih , Tseng Shin-Ling , Lai Yu-Hsuan , Huang Yu-Ting , Kuo Ming-Tse 
Published: December 2017

Purpose:
To investigate the meibomian gland (MG) performance in patients with glaucoma under topical intraocular pressure (IOP)-lowering medications.

Materials and Methods:
This was a cross-sectional case-control study. Patients with glaucoma under different dosages and instillation periods of topical IOP-lowering medications were included. A total of 30 eyes out of 30 healthy participants and 85 eyes out of 85 patients with glaucoma were analyzed. The burden of instilling antiglaucoma agents [burden of antiglaucoma (BAG)] was simply scored for each participant based on the number, formula, frequency, and duration of topical IOP-lowering medications used. All participants completed the MG and tear assessments, including Standard Patient Evaluation of Eye Dryness questionnaire, lipid layer thickness, MG secretion and dropout, Schirmer test, tear break-up time, and blinking patterns.

Results:
Patients with glaucoma had significantly lower Standard Patient Evaluation of Eye Dryness scores, thinner lipid layer thickness, worse mebium quality, and lower MG secretion compared with healthy participants. Among the patients with glaucoma, MG loss ratio (P=0.006) and meiboscale (P=0.017) were significantly correlated with the BAG score. Compared with the low BAG group (score <80), the high BAG group (score ≥80) had significantly shorter tear break-up time (P=0.047), lower MG density (P=0.032), higher MG loss ratio (P=0.011), and higher meiboscale (P=0.036).

Conclusions:
Patients with a higher BAG agents had more unstable tear films and more severe MG dropout. Therefore, MG disease should be particularly observed in patients with glaucoma following a higher BAG regimen.
Fecal Calprotectin Test Performed at Home
Authors: Piekkala Maija , Alfthan Henrik , Merras‐Salmio Laura , Puustinen Wikström Anne , Heiskanen Kaarina , Jaakkola Tytti , Klemetti Paula , Färkkilä Martti , Kolho Kaija‐Leena 
Published: December 2017

ABSTRACTObjectives:Measuring fecal calprotectin (FC) in a laboratory is time‐consuming and that is why home tests have been developed. We studied the use of an FC home test in pediatric patients with inflammatory bowel disease (PIBD) in real‐life settings.Methods:The patients were asked to perform the IBDoc® FC home test monthly for 6 months and to report their clinical disease activity at testing. Clinical decision‐making, however, was guided by routine FC enzyme‐linked immunosorbent assay (ELISA) for patients with raised IBDoc® values. Spare frozen samples were analyzed using ELISA and IBDoc® in the laboratory. The participants completed a questionnaire about FC testing at the start and end of the study.Results:Of the 52 patients, 35 (67%) ages 5 to 18 years completed the study, and 197 home tests were performed. Of these, 15% failed, mainly because of technical reasons. Just under half of the patients (47%) considered home testing comparable or superior to routine testing. In contrast, the parents were unsatisfied (61%), mostly because the IBDoc® results were significantly different from ELISA and they found the phone application difficult to handle but whenever the IBDoc® was performed by a laboratory professional it was comparable with ELISA, suggesting that practical issues hampered home testing. Despite their reservations, more than 80% of parents felt that home testing would improve disease management.Conclusions:PIBD patients and their families were interested in FC home monitoring and willing to adopt testing as a part of their disease management, but this approach requires thorough guidance.
A Rare Complication After Septoplasty: Visual Loss Due to Right Retinal Artery Spasm
Authors: Günay Celal , Altin Gökhan , Kersin Burak , Odabaşi Mahmut 
Published: December 2017

Abstract
Septoplasty is a commonly used procedure for correcting septal cartilage deformities. Hemorrhage, abscesses, scaling, adhesions, and scar tissue are often seen after the operation of the septoplasty, but temporary or permanent visual loss due to local anesthetic use has been reported very rarely in the literature. The authors also aimed to present a female patient with retinal artery spasm in the right eye after septoplasty in this article. A 27-year-old female patient was admitted to the authors’ clinic with long-standing nasal obstruction and postnasal drip. There was no feature in her history and also no sign other than nasal septal deviation on physical examination. The patient was informed about the operation and the operation was planned. Emergency eye consultation was requested after the patient said that the right eye of the patient had never seen in the postoperative wake-up hall. Examination by an ophthalmologist; mild exotropia and total loss of vision in the right eye (including loss of light reflex) was detected. The light reaction in the affected eye was negative and indirect reaction was positive. After enlargement of the pupil, fundus examination revealed that the right posterior pole region (inside of the macula and vessel arches) was pale and no central retinal artery pulsation was observed. The patient was diagnosed with central retinal artery occlusion and emergency intervention was performed. The right eye massage, paracentesis, and hyperbaric oxygen therapy returned to the patient's visual function.
Who is the host of the host-associated microbiome? Colony-level dynamics overshadow individual-level characteristics in the fur microbiome of a social mammal, the Egyptian fruit-bat
Authors: kolodny Oren , Weinberg Maya , Reshef Leah , Harten Lee , Hefetz Abraham , Gophna Uri , Feldman Marcus W , Yovel Yossi 
Published: December 2017

ABSTRACTIn the first longitudinal study of bat microbiomes, we find that unlike the pattern described in humans and other mammals, the prominent dynamics in Egyptian fruit bats’ fur microbiomes are those of change over time at the level of the colony as a whole. Thus, on average, a pair of fur microbiome samples from different individuals in the same colony collected on the same date are more similar to one another than a pair of samples from the same individual collected at different time points. This pattern suggests that the whole colony may be the appropriate biological unit for understanding some of the roles of the host microbiome in social bats’ ecology and evolution. This pattern of synchronized colony changes over time is also reflected in the profile of volatile compounds in the bats’ fur, but differs from the more individualized pattern found in the bats’ gut microbiome.
Copy number variation in fungi and its implications for wine yeast genetic diversity and adaptation
Authors: Steenwyk Jacob L. , Rokas Antonis 
Published: December 2017

AbstractIn recent years, copy number (CN) variation has emerged as a new and significant source of genetic polymorphisms contributing to the phenotypic diversity of populations. CN variants are defined as genetic loci that, due to duplication and deletion, vary in their number of copies across individuals in a population. CN variants range in size from 50 base pairs to whole chromosomes, can influence gene activity, and are associated with a wide range of phenotypes in diverse organisms, including the budding yeastSaccharomyces cerevisiae.In this review, we introduce CN variation, discuss the genetic and molecular mechanisms implicated in its generation, how they can contribute to genetic and phenotypic diversity in fungal populations, and consider how CN variants may influence wine yeast adaptation in fermentation-related processes. In particular, we focus on reviewing recent work investigating the contribution of changes in CN of fermentation-related genes associated with the adaptation and domestication of yeast wine strains and offer notable illustrations of such changes, including the high levels of CN variation among theCUPgenes, which confer resistance to copper, and the preferential deletion and duplication of theMALIandMAL3loci, respectively, which are responsible for metabolizing maltose and sucrose. Based on the available data, we propose that CN variation is a substantial dimension of yeast genetic diversity that occurs largely independent of single nucleotide polymorphisms. As such, CN variation harbors considerable potential for understanding and manipulating yeast strains in the wine fermentation environment and beyond.
Female mate choice is a reproductive isolating barrier inHeliconiusbutterflies
Authors: Southcott Laura , Kronforst Marcus R. 
Published: December 2017

AbstractIn sexually reproducing organisms, speciation involves the evolution of reproductive isolating mechanisms that decrease gene flow. Premating reproductive isolation, often the result of mate choice, is a major obstacle to gene flow between species because it acts earlier in the life cycle than other isolating barriers. While female choice is often considered the default mode in animal species, research in the butterfly genusHeliconius, a frequent subject of speciation studies, has focused on male mate choice. We studied mate choice byH. cydnofemales by pairing them with either conspecific males or males of the closely related speciesH. pachinus.Significantly more intraspecific trials than interspecific trials resulted in mating. Because male courtship rates did not differ between the species when we excluded males that never courted, we attribute this difference to female choice. Females also performed more acceptance behaviours towards conspecific males. Premating isolation between these two species thus entails both male and female mate choice, and female choice may be an important factor in the origin ofHeliconiusspecies.
‘Love builds brains’: representations of attachment and children's brain development in parenting education material
Authors: Wall Glenda 
Published: December 2017

AbstractA focus on early brain development has come to dominate expert child rearing advice over the past two decades. Recent scholars have noted a reinvigoration of the concept of attachment in this advice and changes in the ways that attachment is framed and understood. The extent to which the concept of attachment is drawn on, the way it is framed, and the consequences for mothers, families and parent‐child relationships is examined through a discursive analysis of a current Canadian parental education campaign. Findings support the argument that attachment is receiving a great deal of attention in brain‐based parenting education programmes as children's emotional development becomes increasingly prioritized. Attachment is presented as needing to be actively and continually built through expert‐guided empathetic and responsive parental behaviour, and is framed as crucial for the development of brain pathways that promote emotional strength and self‐regulation in children. Attachment‐building is also presented as requiring highly intensive parenting that falls overwhelmingly to mothers. The parent‐child relationship that is envisioned is one that is instrumental, lacking in affect and conducive to the creation of ideal self‐regulating neo‐liberal citizens.
Melt Electrospun Bilayered Scaffolds for Tissue Integration of a Suture‐Less Inflow Cannula for Rotary Blood Pumps
Authors: Liao Sam , Theodoropoulos Christina , Blackwood Keith A. , Woodruff Maria A. , Gregory Shaun D. 
Published: December 2017

AbstractImplantation of left ventricular assist devices typically requires cardiopulmonary bypass support, which is associated with postoperative complications. A novel suture‐less inflow cannula, which can be implanted without bypass, uses mild myocardial compression to seal the interface, however, this may lead to necrosis of the myocardium. To circumvent this issue, a bilayered scaffold has been developed to promote tissue growth at the interface between cannula and myocardium. The bilayered scaffold consists of a silicone base layer, which mimics the seal, and a melt electrospun polycaprolactone scaffold to serve as a tissue integration layer. Biocompatibility of the bilayered scaffolds was assessed by analyzing cell viability, morphology, and metabolic activity of human foreskin fibroblasts cultured on the scaffolds for up to 14 days. There was no evidence of cytotoxicity and the cells adhered readily to the bilayered scaffolds, revealing a cell morphology characteristic of fibroblasts, in contrast to the low cell adhesion observed on flat silicone sheets. The rate of cell proliferation on the bilayered scaffolds rose over the 14‐day period and was significantly greater than cells seeded on the silicone sheets. This study suggests that melt electrospun bilayered scaffolds have the potential to support tissue integration of a suture‐less inflow cannula for cardiovascular applications. Furthermore, the method of fabrication described here and the application of bilayered scaffolds could also have potential uses in a diverse range of biomedical applications.
Role of clinical and laboratory parameters for treatment choice in patients with inherited FVII deficiency undergoing surgical procedures: evidence from the STER registry
Authors: Di Minno Matteo N. D. , Napolitano Mariasanta , Dolce Alberto , Mariani Guglielmo ,   the STER Study Group
Published: December 2017

SummaryPerioperative bleeding is a major concern in patients with factor VII (FVII) deficiency. Evaluating data of 95 FVII‐deficient patients undergoing 110 surgical procedures (61 major, 49 minor), we assessed the impact of type of surgery, bleeding phenotype and FVII coagulant activity (FVII:C) levels on perioperative replacement therapy (RT). Compared to those with higher FVII:C levels, patients with <3% FVII:C received a higher number of RT doses (8 vs. 2, P = 0·003) for a longer RT duration (3 days vs. 1 day, P = 0·001), with no difference in RT dose. Similarly, patients with a history of major bleeds received a higher number of RT doses (8·5 vs. 2–3, P = 0·013) for a longer RT duration (2 days vs. 1 day, P = 0·005) as compared to those with a history of minor bleeds or to asymptomatic patients. No difference in RT was found among major and minor surgical procedures. Overall, multivariate analysis showed that history of major bleeding was the only independent predictor of number of RT doses (β = 0·352, P = 0·001) and RT duration (β = 0·405, P = 0·018). Overall, a ≈20 μg/kg perioperative RT was efficacious in 95·5% of cases. The infusion should be repeated ≈8 times in high‐risk subsets (i.e. patients with a history of major bleeding).
Familial risks in urolithiasis in the population of Sweden
Authors: Hemminki Kari , Hemminki Otto , Försti Asta , Sundquist Kristina , Sundquist Jan , Li Xinjun 
Published: December 2017

ObjectiveTo assess detailed familial risks for medically diagnosed urolithiasis (UL, urinary tract stone disease) based on nationwide hospital and population records.Patients/Subjects and MethodsSubjects were identified from the Swedish Multigeneration Register in which there were 211 718 patients with UL. Standardised incidence ratios (SIRs) were calculated by comparison to individuals without a family history of UL.ResultsThe highest familial SIRs were invariably found for the same (concordant) type of UL: 2.18 for kidney, 2.20 for ureter, and 1.93 for bladder. SIRs increased from 1.84, when one parent was affected, to 3.54 when both parents were affected, which was a multiplicative interaction. The SIR was 1.79 when one sibling was affected but it increased to 24.91 when two siblings were affected. Such excessive risks (5.2% of familial cases) are probably explained by high‐penetrant genes. A low SIR of 1.29 between spouses suggested a minor contribution by shared environmental factors on the familial risk.ConclusionsThe results point to underlying genetic causes for the observed familial clustering and establish the genetic landscape of UL. Family histories should be taken in UL diagnostics and prevention could follow guidelines recommended for recurrent UL.