bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis and management of hook of hamate fractures
Authors: Kadar Assaf , Bishop Allen T. , Suchyta Marissa A. , Moran Steven L. 
Published: September 2017

The purpose of this study was to evaluate the time to diagnosis and management of hook of hamate fractures in an era of advanced imaging. We performed a retrospective study of 51 patients treated for hook of hamate fractures. Patients were sent a quickDASH questionnaire regarding the outcomes of their treatment. Hook of hamate fractures were diagnosed with advanced imaging at a median of 27 days. Clinical findings of hook of hamate tenderness had better sensitivity than carpal tunnel-view radiographs. Nonunion occurred in 24% of patients with non-operative treatment and did not occur in the operative group. Both treatment groups achieved good clinical results, with a grip strength of 80% compared with the non-injured hand and a median quickDASH score of 2. Advanced imaging improved the time to diagnosis and treatment compared to historical case series. Nonunion is common in patients treated non-operatively. Level of evidence: IV
An Alternate Technique of Applying Lag Screw for Fixation of Distal Fibula Fracture: Posterior to Anterior Interfragmentary Compression Screw
Authors: Vijimohan Suganth Jayaraman , Haque Syed , Ellis David 
Published: September 2017

Ankle fractures are one of the most common lower limb fractures, representing a significant portion of the trauma workload. Marked proportion of these is isolated intraarticular lateral malleolus fractures. Anatomical reduction and rigid internal fixation using lag screw (interfragmentary screw) to provide interfragmentary compression has remained the choice of treatment in selected lateral malleolus fractures. Applying interfragmentary compression screw from anterior to the posterior surface of the fibula has been the traditional method of performing this. In this article, we describe an alternate method of applying posterior-anterior interfragmentary compression screw to the fibula fractures. We will also discuss the benefits it provides such as minimizing the chances of hardware-related peroneal tendon irritation. Further argument will focus on the mechanical benefit this will render while providing equal clinical outcome of the time tested anterior-posterior interfragmentary compression screw. Levels of Evidence: Level V: Therapeutic comparison
Risk factors and outcomes for multidrug-resistant Gram-negative bacilli bacteremia
Authors: Patolia Swati , Abate Getahun , Patel Nirav , Patolia Setu , Frey Sharon 
Published: September 2017

Background: The incidence of multidrug-resistant (MDR) organisms is increasing along with mortality. Identifying risk factors for the development of MDR Gram-negative bacilli (GNB) bacteremia could greatly impact patient care and management. Methods: Data from the electronic health record of patients with GNB over 13-month period were collected at a single university medical center. Baseline demographic data, risk factor, microbiological data, recurrence of bacteremia, and mortality were recorded. Results: A total of 177 patients were included in the analysis. MDR GNB occurred in 46 patients (26%). The mortality rate in the MDR group was 34.8% compared to 13.7% in non-MDR group ( p = 0.002). In multivariate analysis, diabetes mellitus [DM; odds ratio (OR): 2.8, 95% confidence interval (CI): 1–4.88], previous antibiotic use (OR: 2.93, 95% CI: 1.25–6.87), and urinary catheter as a source of infection (OR 5.96, 95% CI: 1.78–19.94) were significant risk factors for the development of MDR GNB. In addition, end-stage liver disease (OR: 3.64, 95% CI: 1.07–12.3), solid organ malignancy (OR: 3.64, 95% CI: 1.25–10.56), intra-abdominal source of infection (OR: 3.66, 95% CI: 1.14–11.73), inappropriate empiric antibiotics (OR 7.59, 95% CI: 1.68–34.34) and urinary catheter as a source of infection (OR 5.68, 95% CI: 1.37–23.5) were significant factors for mortality in patients with MDR GNB. Conclusion: Our study provides important information about the risk factors for the development of MDR GNB bacteremia and helps prognosticate patient with MDR GNB.
TheMUC5Bpromoter polymorphism is associated with specific interstitial lung abnormality subtypes
Authors: Putman Rachel K. , Gudmundsson Gunnar , Araki Tetsuro , Nishino Mizuki , Sigurdsson Sigurdur , Gudmundsson Elías F. , Eiríksdottír Gudny , Aspelund Thor , Ross James C. , San José Estépar Raúl , Miller Ezra R. , Yamada Yoshitake , Yanagawa Masahiro , Tomiyama Noriyuki , Launer Lenore J. , Harris Tamara B. , El-Chemaly Souheil , Raby Benjamin A. , Cho Michael H. , Rosas Ivan O. , Washko George R. , Schwartz David A. , Silverman Edwin K. , Gudnason Vilmundur , Hatabu Hiroto , Hunninghake Gary M. 
Published: September 2017

TheMUC5Bpromoter polymorphism (rs35705950) has been associated with interstitial lung abnormalities (ILA) in white participants from the general population; whether these findings are replicated and influenced by the ILA subtype is not known. We evaluated the associations between theMUC5Bgenotype and ILA in cohorts with extensive imaging characterisation.We performed ILA phenotyping andMUC5Bpromoter genotyping in 5308 and 9292 participants from the AGES-Reykjavik and COPDGene cohorts, respectively.We found that ILA was present in 7% of participants from the AGES-Reykjavik, 8% of non-Hispanic white participants from COPDGene and 7% of African-American participants from COPDGene. Although theMUC5Bgenotype was strongly associated (after correction for multiple testing) with ILA (OR 2.1, 95% CI 1.8–2.4, p=1×10−26), there was evidence of significant heterogeneity between cohorts (I2=81%). When narrowed to specific radiologic subtypes, (e.g.subpleural ILA), theMUC5Bgenotype remained strongly associated (OR 2.6, 95% CI 2.2–3.1, p=1×10−30) with minimal heterogeneity (I2=0%). Although there was no evidence that theMUC5Bgenotype influenced survival, there was evidence thatMUC5Bgenotype improved risk prediction for possible usual interstitial pneumonia (UIP) or a UIP pattern in non-Hispanic white populations.TheMUC5Bpromoter polymorphism is strongly associated with ILA and specific radiologic subtypes of ILA, with varying degrees of heterogeneity in the underlying populations.
Randomised placebo-controlled safety and tolerability trial of FK506 (tacrolimus) for pulmonary arterial hypertension
Authors: Spiekerkoetter Edda , Sung Yon K. , Sudheendra Deepti , Scott Valerie , Del Rosario Patricia , Bill Matthew , Haddad Francois , Long-Boyle Janel , Hedlin Haley , Zamanian Roham T. 
Published: September 2017

Pulmonary arterial hypertension (PAH) is a devastating disease characterised by occlusive pulmonary vasculopathy. Activation of bone morphogenetic protein receptor 2 (BMPR2) signalling by FK506 (tacrolimus) reverses occlusive vasculopathy in rodent PAH models. Here, we determined the safety and tolerability of low-level FK506 therapy in stable PAH patients.We performed a randomised, double-blind, placebo-controlled, 16-week, single-centre, phase IIa trial in PAH patients with New York Heart Association functional class II/III symptoms using three FK506 target levels (<2, 2–3 and 3–5 ng·mL−1). 23 patients were randomised and 20 patients completed the trial.FK506 was generally well tolerated, with nausea/diarrhoea being the most commonly reported adverse event and no observation of line infections in patients on intravenous prostacyclin therapy. PAH patients had significantly lower BMPR2 expression in peripheral blood mononuclear cellsversushealthy controls (n=13; p=0.005), which improved after FK506 treatment. While we observed that some patients responded with a pronounced increase in BMPR2 expression as well as improvement in 6-min walk distance, and serological and echocardiographic parameters of heart failure, these changes were not significant.Low-level FK506 is well tolerated and increases BMPR2 in subsets of PAH patients. These results support the study of FK506 in a phase IIb efficacy trial.
Image recognition performance enhancements using image normalization
Authors: Koo Kyung-Mo , Cha Eui-Young 
Published: September 2017

AbstractWhen recognizing a specific object in an image captured by a camera, we extract local descriptors to compare it with or try direct comparison of images through learning methods using convolutional neural networks. The more the number of objects with many features, the greater the number of images used in learning, the easier it is to compare features. It also makes it easier to detect if the image contains the feature, thus helping generate accurate recognition results. However, there are limitations in improving the recognition performance when the feature of the object to be recognized in the image is significantly smaller than the background area or when the area of the image to be learned is insufficient. In this paper, we propose a method to enhance the image recognition performance through feature extraction and image normalization called the preprocessing process, especially useful for electronic objects with few distinct recognition characteristics due to functional/material specificity.
Prognostic Model to Predict Post-Autologous Stem-Cell Transplantation Outcomes in Classical Hodgkin Lymphoma
Authors: Chan Fong Chun , Mottok Anja , Gerrie Alina S. , Power Maryse , Nijland Marcel , Diepstra Arjan , van den Berg Anke , Kamper Peter , d’Amore Francesco , d’Amore Alexander Lindholm , Hamilton-Dutoit Stephen , Savage Kerry J. , Shah Sohrab P. , Connors Joseph M. , Gascoyne Randy D. , Scott David W. , Steidl Christian 
Published: September 2017

Purpose Our aim was to capture the biology of classical Hodgkin lymphoma (cHL) at the time of relapse and discover novel and robust biomarkers that predict outcomes after autologous stem-cell transplantation (ASCT). Materials and Methods We performed digital gene expression profiling on a cohort of 245 formalin-fixed, paraffin-embedded tumor specimens from 174 patients with cHL, including 71 with biopsies taken at both primary diagnosis and relapse, to investigate temporal gene expression differences and associations with post-ASCT outcomes. Relapse biopsies from a training cohort of 65 patients were used to build a gene expression–based prognostic model of post-ASCT outcomes (RHL30), and two independent cohorts were used for validation. Results Gene expression profiling revealed that 24% of patients exhibited poorly correlated expression patterns between their biopsies taken at initial diagnosis and relapse, indicating biologic divergence. Comparative analysis of the prognostic power of gene expression measurements in primary versus relapse specimens demonstrated that the biology captured at the time of relapse contained superior properties for post-ASCT outcome prediction. We developed RHL30, using relapse specimens, which identified a subset of high-risk patients with inferior post-ASCT outcomes in two independent external validation cohorts. The prognostic power of RHL30 was independent of reported clinical prognostic markers (both at initial diagnosis and at relapse) and microenvironmental components as assessed by immunohistochemistry. Conclusion We have developed and validated a novel clinically applicable prognostic assay that at the time of first relapse identifies patients with unfavorable post-ASCT outcomes. Moving forward, it will be critical to evaluate the clinical use of RHL30 in the context of positron emission tomography–guided response assessment and the evolving cHL treatment landscape.
Effects of Education and Income on Treatment and Outcome in Patients With Acute Myeloid Leukemia in a Tax-Supported Health Care System: A National Population-Based Cohort Study
Authors: Østgård Lene Sofie Granfeldt , Nørgaard Mette , Medeiros Bruno C. , Friis Lone Smidstrup , Schoellkopf Claudia , Severinsen Marianne Tang , Marcher Claus Werenberg , Nørgaard Jan Maxwell 
Published: September 2017

Purpose Previous US studies have shown that socioeconomic status (SES) affects survival in acute myeloid leukemia (AML). However, no large study has investigated the association between education or income and clinical characteristics, treatment, and outcome in AML. Methods To investigate the effects of education and income in a tax-supported health care system, we conducted a population-based study using individual-level SES and clinical data on all Danish patients with AML (2000 to 2014). We compared treatment intensity, allogeneic transplantation, and response rates by education and income level using logistic regression (odds ratios). We used Cox regression (hazard ratios [HRs]) to compare survival, adjusting for age, sex, SES, and clinical prognostic markers. Results Of 2,992 patients, 1,588 (53.1%) received intensive chemotherapy. Compared with low-education patients, highly educated patients more often received allogeneic transplantation (16.3% v 8.7%). In intensively treated patients younger than 60 years of age, increased mortality was observed in those with lower and medium education (1-year survival, 66.7%; adjusted HR, 1.47; 95% CI, 1.11 to 1.93; and 1-year survival, 67.6%; adjusted HR, 1.55; CI, 1.21 to 1.98, respectively) compared with higher education (1-year survival, 76.9%). Over the study period, 5-year survival improvements were limited to high-education patients (from 39% to 58%), increasing the survival gap between groups. In older patients, low-education patients received less intensive therapy (30% v 48%; adjusted odds ratio, 0.65; CI, 0.44 to 0.98) compared with high-education patients; however, remission rates and survival were not affected in those intensively treated. Income was not associated with therapy intensity, likelihood of complete remission, or survival (high income: adjusted HR, 1.0; medium income: adjusted HR, 0.96; 95% CI, 0.82 to 1.12; low income: adjusted HR, 1.06; CI, .88 to 1.27). Conclusion In a universal health care system, education level, but not income, affects transplantation rates and survival in younger patients with AML. Importantly, recent survival improvement has exclusively benefitted highly educated patients.
Konsepsi Disabilitas dan Pendidikan Inklusif
Authors: Yulianto M. Joni 
Published: September 2017

In the past decade, inclusive education has been a global rethoric and enjoyed significant scholarly attention. Drawing from Indonesian experience, this paper seeks to establish a clear link between disability and inclusive education. The author argues that the concept ofinclusive education in Indonesia is not yet well understood by the educational practioners and policy maker and consequently,has hampered the implementation of this policy in the field. It is only through appropriate understanding of disability that the concept of inclusive education would be better comprehended and implemented.Based on the examination of inclusive education policies and various aspect of its implementation, this paper also offers series of recommendation aimed for better impelementation of this policy in Indonesia. Among the recommendations are adequate resources, better political willingness, multi stake holder participation as well as wider support system.
The Effects of Explicit Metapragmatic Instruction on Chinese English Language Learners’ Acquisition of Compliment Responses
Authors: Wen Zhou , Jun Deng 
Published: September 2017

Abstract
The present study investigated the effects of explicit metapragmatic instruction on foreign language learners’ performance of compliment responses (CRs). Eighty-two non-English major students participated in this study. They were randomly assigned to two groups, an experimental group that received explicit metapragmatic instruction on compliment responses and a control group that did not. A pretest-posttest research design was adopted. The data were collected through a written discourse completion task (WDCT) with six scenarios concerning the topics of appearance, performance, and personality. The results revealed that learners who received explicit instruction dramatically decreased their use of Accept strategy and increased Combination (CB) strategy at the macro level; more specifically, a decrease in Appreciation and an increase in Accept + Accept at the micro level. The learners of the control group made little progress in their performance. The study sheds light on pragmatics learning in an EFL setting and provides implications for pragmatics pedagogy.
Valorization of human hair as methylene blue dye adsorbents
Authors: Ahmad Zaini Muhammad Abbas , Sudi Raidah Md. 
Published: September 2017

AbstractThe present study was aimed at evaluating the performance of human hair as adsorbents for methylene blue (MB) dye removal. Human hair was treated using 0.1mpotassium hydroxide (KOH) and 0.1mnitric acid, and the adsorbents were characterized for specific surface area and surface chemistry. The basic-treated human hair adsorbent (BH) exhibits a specific surface area of 3.51 m2/g, which is relatively higher than the acid-treated (AH) and untreated (UH) counterparts. The equilibrium data of all adsorbents obeyed the S-shaped isotherm, suggesting a cooperative adsorption. The BH displays a maximum capacity of 13.5 mg/g, while a comparable capacity of 3.4 mg/g was recorded by AH and UH. The adsorption of MB by BH increased with increasing pH. Based on the equilibrium and kinetics data, the adsorption of MB onto BH is proposed to have the following mechanisms: (i) external diffusion, (ii) intraparticle diffusion, and (iii) cooperative adsorption. In addition, the MB adsorption at a concentration of 20 mg/l is endothermic and spontaneous with temperature increasing from 35°C to 55°C. A basic treatment of human hair using KOH yields a promising adsorbent for dye in wastewater treatment.
Does Evidence Challenge the Dsge Model?
Authors: Araújo Tanya , Terlica Sofia , Eleutério Samuel , Louçã Francisco 
Published: September 2017

ABSTRACT
DSGE are for a time the favorite models in the simulation of monetary policies at the central banks. Two of its basic assumptions are discussed in this paper: (a) the absence of endogenous nonlinearities and the exogenous nature of shocks and (b) the persistence of or the return to equilibrium after a shock, or the absence of dynamics. Our analysis of complex financial markets, using historical data of S&P500, suggests otherwise that financial regimes endogenously change and that equilibrium is an artifact.
An Approach To E-Workflow Systems With The Use Of Patterns
Authors: Ndeta John , Katriou Stamatia A. , Siakas Kerstin V. 
Published: September 2017

Abstract
In today’s highly competitive and rapidly changing environment, e-businesses constantly have to modify their business processes, i.e. the flow of documents and tasks in a business also known as workflow. More flexible Workflow Management Systems are required to support these constantly changing processes. In this research a platform independent architecture for the design of e-workflow systems is illustrated. The architecture includes an information pool, namely a Workflow Pattern Repository, which contains patterns, which are repeatable solutions to reoccurring problems, in order to make the system more apt to change and assist the workflow designer/user in defining workflows faster and more accurately. The patterns in the repository are in the form of UML activity diagram templates. A straightforward input format for storing patterns in the repository is provided along with an example of its practical application.
Measuring Website Quality Of The Indian Railways
Authors: Jain Rajesh Kumar , Rangnekar Santosh 
Published: September 2017

Abstract
Websites are being widely used for commercial purpose in both private and public sectors. Whether such widespread use and dependency on web enhances the satisfaction among its users or not is to be understood. The objective of the present study is to examine and analyze the quality of the website of the Indian Railways.
The Indian Railways website quality was compared with a perceived ideal website. The attributes for assessing the website quality of a railways were developed on the basis of pertaining literature review, interview with some of the web site users and with personal observations. In the present study the mean value in case of the Indian Railways is 36.28 and in case of perceived ideal website the mean value is 45.06. The F-statistic value is 52.75. The result allows us to infer that the Indian Railways website quality is not on the mark compared to what the users expect in a perceived ideal website.
The implication of the present study is that the Indian Railways should focus on the quality of its website for increased user satisfaction and for enhancing its image.
Real Silver and Its Investment and Business Options
Authors: Novotný Josef , Polách Jiří 
Published: September 2017

Abstract
The article deals with investment and business opportunities offered by silver. Silver is the metal used in industry and for investing at financial markets. The main problem related to this real commodity is the issue of “the undervaluation” of its investment options, if compared to gold. If considering silver as the investment option, its investment potential is significantly enhanced by its industrial usage. The aim of this paper is to highlight business and investment opportunities for both professionals and non professional investors at the commodity markets. The price growth of this investment and industrial metal can generate profits for the investors. And on the other hand, industries which cannot do without silver in their production may efficiently utilize the knowledge of setting up its price at the markets.
Robo Advisory und automatisierte Vermögensverwaltung
Authors: Fischer Matthias 
Published: September 2017

Zusammenfassung
Genossenschaftsbanken, Privatbanken, Sparkassen und Asset Manager beschäftigen sich intensiv mit der digitalen, automatisierten Geldanlageberatung und Vermögensverwaltung. Einerseits steigen die Kosten für die Dokumentationspflichten durch die zunehmende Regulierung der Anlageberatung. Andererseits reduzieren sich die Margen bzw. Erträge aufgrund kostengünstiger ETF-Produkte und dem Zwang zu mehr Gebührentransparenz sowie dem Verbot von Kickbacks. Für Privatanleger mit relativ kleinen Anlagebeträgen zwischen 1.000 Euro und 50.000 Euro wird es schwieriger, eine neutrale und qualifizierte persönliche Beratung zu bekommen, weil der Aufwand für die Bank nicht durch genügend Erträge gedeckt wird. Online-Lösungen sind daher sehr wichtige Alternativen, um für die Kunden weiterhin eine neutrale sowie kostengünstige Beratung zu garantieren. Durch die Automatisierung kann auch das kleinteilige Geschäft für die Banken rentabel gestaltet werden.
EFFECT OF FUEL PRICES ON COST-EFFECTIVENESS OF HEATING SYSTEMS FOR BROILER POULTRY BARNS
Authors: Hope Emily , WEERSINK ALFONS , VAN HEYST BILL , Fox Glenn 
Published: September 2017

Recent advances in extraction have increased the supply of natural gas and increased the relative price difference between it and alternative fuels. However, natural gas is not available in many rural areas forcing poultry producers unable to access natural gas to use more expensive fuels. This paper determines the least cost appliance system and fuel source for heating a broiler chicken barn in Ontario, Canada. The empirical model estimates the amount of heat required for poultry production, selects appropriate heating appliances and fuel types, and calculates the final present value of costs over a 20-year period. Appliances examined include box heaters, radiant tube heaters and biomass boilers; fuels examined include natural gas, propane, heating oil and biomass. Natural gas is the least cost fuel for both box heaters and radiant tube heaters assuming there is an existing connection to a gas pipeline. However, natural gas heating systems become the most expensive approach if the poultry operator has to pay for a pipeline connection to the gas source. With no direct connection for natural gas, biomass boilers are the most cost efficient heating system, followed closely by radiant tube heaters fuelled by propane. Heating oil is the most expensive fuel examined and its costs are nearly double that for comparable box heaters and radiant tube heaters using propane.