bluuebunny/crossref_metadata_2025_split huggingface dataset:
Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial
Authors: Zak Victor , Hsu Daphne T. , Pemberton Victoria L. , Levine Jami C. , Atz Andrew M. , Cnota James F. , Ravishankar Chitra , Barker Piers , Lambert Linda M. , McCrindle Brian W. , Frommelt Michele A. , Altmann Karen , Chen Shan , Williams Richard V. ,   for the Pediatric Heart Network Investigators
Published: February 2017

AbstractBackgroundA few studies have evaluated the impact of clinical trial results on practice in paediatric cardiology. The Infant Single Ventricle (ISV) Trial results published in 2010 did not support routine use of the angiotensin-converting enzyme inhibitor enalapril in infants with single-ventricle physiology. We sought to assess the influence of these findings on clinical practice.MethodsA web-based survey was distributed via e-mail to over 2000 paediatric cardiologists, intensivists, cardiothoracic surgeons, and cardiac advance practice nurses during three distribution periods. The results were analysed using McNemar’s test for paired data and Fisher’s exact test.ResultsThe response rate was 31.5% (69% cardiologists and 65% with >10 years of experience). Among respondents familiar with trial results, 74% reported current practice consistent with trial findings versus 48% before trial publication (p<0.001); 19% used angiotensin-converting enzyme inhibitor in this population “almost always” versus 36% in the past (p<0.001), and 72% reported a change in management or improved confidence in treatment decisions involving this therapy based on the trial results. Respondents familiar with trial results (78%) were marginally more likely to practise consistent with the trial results than those unfamiliar (74 versus 67%, p=0.16). Among all respondents, 28% reported less frequent use of angiotensin-converting enzyme inhibitor over the last 3 years.ConclusionsWithin 5 years of publication, the majority of respondents was familiar with the Infant Single Ventricle Trial results and reported less frequent use of angiotensin-converting enzyme inhibitor in single-ventricle infants; however, 28% reported not adjusting their clinical decisions based on the trial’s findings.
The Figures of Kōho and Li-mi-i, and the Origins of the Case for a Christian Missionary Presence in Tenpyō Era Japan
Authors: MORRIS JAMES HARRY 
Published: February 2017

AbstractIn 1916 P.Y. Saeki devoted a page of his book “The Nestorian Monument in China,” to a short thought experiment which linked a Persian by the name of Li-mi-i 李密翳 who was present in Emperor Shōmu's 聖武天皇 court and whose arrival was mentioned in the Shoku Nihongi 続日本紀 with a priest named on the Nestorian Stele. Since that first suggestion, several scholars have expounded the idea that Li-mi-i and another figure who arrived alongside him, Kōho Tōchō 皇甫東朝, were Christians and/or missionaries. In this paper I assess these claims, returning to the Shoku Nihongi in order to suggest that there is a lack of data to establish them as true. I then seek to explore the origins of this theory situating it within the joint context of Japan's imperial expansion and her modernization. Whilst the latter cannot be conclusive, I hope that it may shed light on the significance of the theory which can be seen as a search to discover Japanese history, a statement of the equality between Japanese and Western histories, or an attempt to justify imperial aims in China academically.
Miniaturized dual-band filter with return loss bandwidth and transmission zero control
Authors: Lu Di , Barker N. Scott , Tang Xiao-Hong 
Published: February 2017

In this paper, a compact dual-band bandpass filter (DB-BPF) using new dual-mode resonator-loaded resonators (DM-RLRs) is presented and investigated to simultaneously achieve controllable return loss (RL), bandwidth (BW) and transmission zeros (TZs), and the simple strategy for this type of filter design is proposed. The DB-BPF consists of two high-flexibility DM-RLRs with separated electric and magnetic coupling (SEMC). Specifically, the proposed DM-RLR provides the DB-BPF with center frequency control as well as RL control, and SEMC is utilized for the BW and TZ control. To facilitate the design, a simple optimization-based design strategy is proposed and employed, resulting in an example layout. Finally, the example filter, with center frequencies of 1.57 GHz (channel 1 for GPS) and 3.5 GHz (channel 2 for WiMAX), is fabricated and measured. The measurement insertion loss and RL are 0.9/0.9 and 17/20 dB. The fabricated DB-BPF also exhibits a compact size of 0.12λg × 0.08λg at 1.57 GHz.
Prognostic significance of social network, social support and loneliness for course of major depressive disorder in adulthood and old age
Authors: van den Brink R. H. S. , Schutter N. , Hanssen D. J. C. , Elzinga B. M. , Rabeling-Keus I. M. , Stek M. L. , Comijs H. C. , Penninx B. W. J. H. , Oude Voshaar R. C. 
Published: February 2017

Aims.Poor recovery from depressive disorder has been shown to be related to low perceived social support and loneliness, but not to social network size or frequency of social interactions. Some studies suggest that the significance of social relationships for depression course may be greater in younger than in older patients, and may differ between men and women. None of the studies examined to what extent the different aspects of social relationships have unique or overlapping predictive values for depression course. It is the aim of the present study to examine the differential predictive values of social network characteristics, social support and loneliness for the course of depressive disorder, and to test whether these predictive associations are modified by gender or age.Methods.Two naturalistic cohort studies with the same design and overlapping instruments were combined to obtain a study sample of 1474 patients with a major depressive disorder, of whom 1181 (80.1%) could be studied over a 2-year period. Social relational variables were assessed at baseline. Two aspects of depression course were studied: remission at 2-year follow-up and change in depression severity over the follow-up period. By means of logistic regression and random coefficient analysis, the individual and combined predictive values of the different social relational variables for depression course were studied, controlling for potential confounders and checking for effect modification by age (below 60 v. 60 years or older) and gender.Results.Multiple aspects of the social network, social support and loneliness were related to depression course, independent of potential confounders – including depression severity – but when combined, their predictive values were found to overlap to a large extent. Only the social network characteristic of living in a larger household, the social support characteristic of few negative experiences with the support from a partner or close friend, and limited feelings of loneliness proved to have unique predictive value for a favourable course of depression. Little evidence was found for effect modification by gender or age.Conclusions.If depressed persons experience difficulties in their social relationships, this may impede their recovery. Special attention for interpersonal problems, social isolation and feelings of loneliness seems warranted in depression treatment and relapse prevention. It will be of great interest to test whether social relational interventions can contribute to better recovery and relapse prevention of depressive disorder.
Employability and Temporary Workers’ Affective Commitment: the Moderating Role of Voluntariness
Authors: Espada Mafalda , Chambel Maria José 
Published: February 2017

AbstractThe development of either internal or external employability of temporary workers has been considered a mechanism of protection since it ensures that employment can be maintained. According to the social exchange theory and the norm of reciprocity, when temporary workers perceive that the training promoted by the organization furthers employability, they are inclined to feel obligated to reciprocate with positive attitudes toward the organization. With a sample of temporary agency workers from three distinct industry organizations (N= 279), the current study investigated the relationship between training that promotes both internal and external employability and affective commitment as well as the role of voluntariness as a moderator of these relationships. The hypotheses were tested by using regression analysis. The results indicated that the perception held by temporary workers that the training they received is a promoter of their internal employability is positively correlated with their affective commitment towards the organization. Furthermore, the data revealed that this relationship is weaker for the group of temporary workers with high voluntariness. On the other hand, there was not a significant relationship between the training that promotes external employability and the affective commitment of temporary workers. Likewise, voluntariness did not moderate this relationship.
Representations and Antinomies: Rural and City Social Objects in a Brazilian Peasant Community
Authors: Bonomo Mariana , de Souza Lídio , Trindade Zeidi Araujo , Menandro Maria Cristina Smith 
Published: February 2017

AbstractThe present work is part of a series of studies that primarily focus on social representations of rural and city objects in the process of constructing a social identity of the countryside. Using social representation theory, this study aimed to investigate the representational field linked to the rural and city objects for the members of a peasant community. A total of 200 members of a Brazilian rural community from four generational groups, of both sexes and aged between 7 and 81 years, participated in this study. We conducted individual interviews with semi-structured scripts. The datacorpora, processed using EVOCsoftware, consisted of free associations of the rural and city inductor terms. In constitutive terms, the results allow for the identification of antinomies between the objects discussed; in functional terms, they indicate that the process of constructing social identity is based on the symbolic field, which acts as a reference system for the preparation of the rural identity shared by the participants.
Retiring from Elite Sports in Greece and Spain
Authors: Dimoula Fani , Torregrosa Miquel , Psychountaki Maria , Fernandez Maria Dolores Gonzalez 
Published: February 2017

AbstractThe main objective of the present study was to compare the athletic retirement of elite Greek and Spanish athletes in terms of (a) pre-conditions of retirement, (b) transitional period, and (c) consequences of the transition. For this purpose, elite athletes from Greece (n= 76) and Spain (n= 57) described in retrospect their experience leaving competitive sports through the Retirement from Sports Survey (Alfermann, Stambulova, & Zemaityte, 2004). Separate one-way ANOVAs and chi-square tests revealed differences and similarities between the transitional processes of athletes from the two countries. More similarities than differences were detected in the retirement of Greek and Spanish athletes. Based on these commonalities, we proposed a Southern European perspective on the topic. According to the present results the main characteristics of this pattern could be the lack of retirement planning, high athletic identity after the sports career, and predominance of relocation in the sports world after retirement.
Unpredictability and Context Conditioning: Does the Nature of the US Matter?
Authors: Meulders Ann , Boddez Yannick , Vansteenwegen Debora , Baeyens Frank 
Published: February 2017

AbstractUsing a conditioned suppression task, we examined the minimal conditions to establish context conditioning as induced by unpredictability of an unconditioned stimulus (US). We investigated whether a biologically significant US is necessary to produce such context conditioning effects. In this between-subjects experiment, we manipulated the nature of the US and US-unpredictability. In the Paired condition, the conditioned stimulus (CS) was always followed by the US, whereas in the Unpaired condition, the CS and the US were presented explicitly unpaired, that is, the CS was never followed by the US. Half of the participants received an aversive, biologically significant human scream, and the other half received a more neutral, biologically non-significant sound as US. Results show more contextual suppression in the Unpaired condition than in the Paired condition. We conclude that in an expectancy-based conditioning task, US-unpredictability, but not a biologically potent US, is crucial to establish context conditioning.
Perceptions of the Self and most People’s Reactions towards Innocent and Noninnocent Victims
Authors: Alves Hélder , Correia Isabel 
Published: February 2017

AbstractResearch has shown that: individuals positively distinguish themselves from most other people; being consistent is positively valued; injunctive and descriptive norms are perceived to protect victims. Joining these findings, we argue that individuals present themselves as following injunctive and descriptive norms towards victims to a higher extent and more consistently than most people. In an experimental study 273 university students of both sexes indicated what they and most other people would approve of (injunctive norm) or typically do (descriptive norm) regarding various reactions towards either an innocent or a noninnocent victim. The reactions involved secondary victimization (devaluation/derogation, avoidance, suffering minimization, blaming the victim) and non secondary victimization (valuation, contact, suffering acknowledgment, not blaming the victim). Participants perceived themselves and most people as approving of more non secondary than secondary victimization reactions, except for blaming the noninnocent victim. Participants indicated they approved of most of the normative reactions to a higher extent than most people, which is interpreted as a new instance of the Primus Inter Pares effect. Participants also indicated they would show more consistency between their injunctive and descriptive norms, especially towards the innocent victim. Results suggest that individuals perceive themselves as more immune to perverse norms than most people.
Latin American Students and Language Learning in Catalonia: What does the Linguistic Interdependence Hypothesis show us?
Authors: Huguet Ángel 
Published: February 2017

AbstractThe massive arrival in Spain of students of immigrant origin has visibly altered the traditional configuration of schools, where ethnic, cultural and linguistic diversity is becoming increasingly manifest. This situation is worth being mentioned insofar as it affects all the different autonomous communities in the country, even more clearly Catalonia, where the educational system is organized under the parameters of bilingual education. One of the theoretical constructs supporting this educational model is the Linguistic Interdependence Hypothesis, developed by Jim Cummins at the beginning of the 1980s. According to the author, whenever the instruction in a given language (Lx) takes place under certain conditions, competence acquired in this language can be transferred onto another (Ly). Bearing this theoretical construct in mind, our study focuses on a sample of 237 Spanish-speaking subjects (123 native and 114 immigrant students) who completed a series of parallel tests evaluating their skills in Catalan and Spanish. Drawing on the data analyzed we can conclude that the Hypothesis accounts for the results in both native and immigrant students with the same L1.
Pharmacoeconomic analysis of antibiotic therapy in maxillofacial surgery
Authors: Orzechowska-Wylęgała Bogusława , Wylęgała Adam , Buliński Michał , Niedzielska Iwona , Madej Andrzej 
Published: February 2017

AbstractObjectives/Aims:The aim of this study was to investigate the microbial cultures collected in the years 2013–2014 at the craniomaxillofacial department and outpatient clinic to analyse optimisation of the treatment cost of the bacterial infections and present the results.Design and setting:We analysed 485 cultures from 263 patients, of which 77.28% consisted of Gram-positive bacteria. On the basis of the antibiotic efficacy, antibiotic price and the cost of entire treatment during hospitalisation, the most useful antimicrobial agents for the most common pathogens were selected.Results:The most frequently collected material was pus. The most common pathogens were found to be theStaphylococcus epidermidis(18%),Streptococcus mitisandStr. oralis(14%) andS. aureus(6.5%).Discussion:The most frequently isolated bacteria in other studies were theStreptococcusstrain. Other authors showed that ceftriaxone is the most cost efficient agent. The use of postoperative antibiotic prophylaxis remains controversial.Conclusion:The results of this study suggest that the most useful antibiotics for therapy, from the perspective of the cost minimisation, were gentamycin, trimethoprim with sulfamethoxazole and vancomycin.
MASTL is essential for anaphase entry of proliferating primordial germ cells and establishment of female germ cells in mice
Authors: Risal Sanjiv , Zhang Jingjing , Adhikari Deepak , Liu Xiaoman , Shao Jingchen , Hu Mengwen , Busayavalasa Kiran , Tu Zhaowei , Chen Zijiang , Kaldis Philipp , Liu Kui 
Published: February 2017

AbstractIn mammals, primordial germ cells (PGCs) are the embryonic cell population that serve as germ cell precursors in both females and males. During mouse embryonic development, the majority of PGCs are arrested at the G2 phase when they migrate into the hindgut at 7.75–8.75 dpc (days post coitum). It is after 9.5 dpc that the PGCs undergo proliferation with a doubling time of 12.6 h. The molecular mechanisms underlying PGC proliferation are however not well studied. In this work. Here we studied how MASTL (microtubule-associated serine/threonine kinase-like)/Greatwall kinase regulates the rapid proliferation of PGCs. We generated a mouse model where we specifically deleted Mastl in PGCs and found a significant loss of PGCs before the onset of meiosis in female PGCs. We further revealed that the deletion of Mastl in PGCs did not prevent mitotic entry, but led to a failure of the cells to proceed beyond metaphase-like stage, indicating that MASTL-mediated molecular events are indispensable for anaphase entry in PGCs. These mitotic defects further led to the death of Mastl-null PGCs by 12.5 dpc. Moreover, the defect in mitotic progression observed in the Mastl-null PGCs was rescued by simultaneous deletion of Ppp2r1a (α subunit of PP2A). Thus, our results demonstrate that MASTL, PP2A, and therefore regulated phosphatase activity have a fundamental role in establishing female germ cell population in gonads by controlling PGC proliferation during embryogenesis.
Underlying mechanisms for syntrophic metabolism of essential enzyme cofactors in microbial communities
Authors: Romine Margaret F , Rodionov Dmitry A , Maezato Yukari , Osterman Andrei L , Nelson William C 
Published: February 2017

Abstract
Many microorganisms are unable to synthesize essential B vitamin-related enzyme cofactors de novo. The underlying mechanisms by which such microbes survive in multi-species communities are largely unknown. We previously reported the near-complete genome sequence of two ~18-member unicyanobacterial microbial consortia that maintain stable membership on defined medium lacking vitamins. Here we have used genome analysis and growth studies on isolates derived from the consortia to reconstruct pathways for biogenesis of eight essential cofactors and predict cofactor usage and precursor exchange in these communities. Our analyses revealed that all but the two Halomonas and cyanobacterial community members were auxotrophic for at least one cofactor. We also observed a mosaic distribution of salvage routes for a variety of cofactor precursors, including those produced by photolysis. Potentially bidirectional transporters were observed to be preferentially in prototrophs, suggesting a mechanism for controlled precursor release. Furthermore, we found that Halomonas sp. do not require cobalamin nor control its synthesis, supporting the hypothesis that they overproduce and export vitamins. Collectively, these observations suggest that the consortia rely on syntrophic metabolism of cofactors as a survival strategy for optimization of metabolic exchange within a shared pool of micronutrients.
Bacterial community dynamics are linked to patterns of coral heat tolerance
Authors: Ziegler Maren , Seneca Francois O. , Yum Lauren K. , Palumbi Stephen R. , Voolstra Christian R. 
Published: February 2017

AbstractOcean warming threatens corals and the coral reef ecosystem. Nevertheless, corals can be adapted to their thermal environment and inherit heat tolerance across generations. In addition, the diverse microbes that associate with corals have the capacity for more rapid change, potentially aiding the adaptation of long-lived corals. Here, we show that the microbiome of reef corals is different across thermally variable habitats and changes over time when corals are reciprocally transplanted. Exposing these corals to thermal bleaching conditions changes the microbiome for heat-sensitive corals, but not for heat-tolerant corals growing in habitats with natural high heat extremes. Importantly, particular bacterial taxa predict the coral host response in a short-term heat stress experiment. Such associations could result from parallel responses of the coral and the microbial community to living at high natural temperatures. A competing hypothesis is that the microbial community and coral heat tolerance are causally linked.
Conformational changes in intact dengue virus reveal serotype-specific expansion
Authors: Lim Xin-Xiang , Chandramohan Arun , Lim Xin Ying Elisa , Bag Nirmalya , Sharma Kamal Kant , Wirawan Melissa , Wohland Thorsten , Lok Shee-Mei , Anand Ganesh S. 
Published: February 2017

AbstractDengue virus serotype 2 (DENV2) alone undergoes structural expansion at 37 °C (associated with host entry), despite high sequence and structural homology among the four known serotypes. The basis for this differential expansion across strains and serotypes is unknown and necessitates mapping of the dynamics of dengue whole viral particles to describe their coordinated motions and conformational changes when exposed to host-like environments. Here we capture the dynamics of intact viral particles of two serotypes, DENV1 and DENV2, by amide hydrogen/deuterium exchange mass spectrometry (HDXMS) and time resolved Förster Resonance Energy Transfer. Our results show temperature-dependent dynamics hotspots on DENV2 and DENV1 particles with DENV1 showing expansion at 40 °C but not at 37 °C. HDXMS measurement of virion dynamics in solution offers a powerful approach to identify potential epitopes, map virus-antibody complex structure and dynamics, and test effects of multiple host-specific perturbations on viruses and virus-antibody complexes.