bluuebunny/crossref_metadata_2025_split huggingface dataset:
SciLite: a platform for displaying text-mined annotations as a means to link research articles with biological data
Authors: Venkatesan Aravind , Kim Jee-Hyub , Talo Francesco , Ide-Smith Michele , Gobeill Julien , Carter Jacob , Batista-Navarro Riza , Ananiadou Sophia , Ruch Patrick , McEntyre Johanna 
Published: December 2016

Biological databases are fundamental to biological research and discovery. Database curation adds highly precise and useful information, usually extracted from the literature through experts reading research articles. The significant amount of time and effort put in by curators, against the backdrop of tremendous data growth, makes manual curation a high value task. Therefore, there is an urgent need to find ways to scale curation efforts by improving data integration, linking literature to the underlying data. As part of the development of Europe PMC, we have developed a new platform, SciLite, that overlays text-mined annotations on research articles. The aim is to aid Europe PMC users in finding key concepts more easily and provide links to related resources or tools, bridging the gap between literature and biological data.
Effect of chronic wound fluid on fibroblasts
Authors: Phillips T.J. , Al-Amoudi H.O. , Leverkus M. , Park H-Y. 
Published: December 2016

This study examines how the microenvironment created by fluid in chronic wounds influences the growth of dermal fibroblasts. Newborn fibroblasts, which are known to grow rapidly, were used as a model system to explore how chronic wound fluid affects the growth of regenerative fibroblasts. Wound fluid was collected from patients with chronic venous leg ulcers (duration longer than two months). The biological properties of this fluid were then further characterised to elucidate its molecular effects on cell growth. Results indicate that chronic wound fluid dramatically inhibited the growth of newborn dermal fibroblasts. This growth inhibitory effect was variable among donors, reversible and heat-sensitive. The inhibitory effect was due not to cytotoxicity or impaired plating efficiency of these cells, but to specific interference with the cell cycle. Chronic wound fluid arrested newborn fibroblast growth by preventing entry into the S-phase, or DNA synthesis-phase, of the cell cycle. In contrast to its effects on newborn fibroblasts, chronic wound fluid either stimulated or had a minimal effect on fibroblasts which had been cultured from the edge of chronic venous leg ulcers and healthy tissue on the upper thigh in the same patient. This may partially account for the impaired healing seen in chronic venous leg ulcers.
The validation of quantum chemical lipophilicity prediction of alcohols
Authors: Michalík Martin , Lukeš Vladimír 
Published: December 2016

Abstract
The validation of octanol-water partition coefficients (logP) quantum chemical calculations is presented for 27 alkane alcohols. The chemical accuracy of predicted logP values was estimated for six DFT functionals (B3LYP, PBE0, M06-2X, ωB97X-D, B97-D3, M11) and three implicit solvent models. Triple-zeta basis set 6-311++G(d,p) was employed. The best linear correlation with the experimental logP values was achieved for the B3LYP and B97-D3 functionals combined with the SMD model. On the other hand, no linearity was found when IEF-PCM or C-PCM implicit models were employed.
Gallic acid: thermodynamics of the homolytic and heterolytic phenolic O—H bonds splitting-off
Authors: Škorňa Peter , Michalík Martin , Klein Erik 
Published: December 2016

Abstract
The DFT study of primary antioxidant action of gallic acid and its carboxylic anion is presented in the gas-phase, benzene and water. Corresponding reaction enthalpies for three possible mechanisms was calculated using B3LYP/6-311++G** method. Bond dissociation enthalpy (BDE) and proton dissociation enthalpy (PDE) of 4-OH group was found to be the lowest in gas-phase as well as in both solvents approximated by IEF-PCM model. Ionization potentials (IPs) were higher than BDEs in all cases. Deprotonation of carboxylic group result in increased antioxidant potency as drop in BDE, proton affinities (PAs) and IPs was indicated in all environments.
Buckwheat cultivars — phenolic compounds profiles and antioxidant properties
Authors: Mikulajová Anna , Šedivá Dominika , Hybenová Eva , Mošovská Silvia 
Published: December 2016

Abstract
Common buckwheat (Fagopyrum esculentum) and tartary buckwheat (Fagopyrum tataricum) cultivars originating in different world countries were investigated and compared for their quantitative and qualitative abundance of phenolics and flavonoids. Moreover, the antioxidant properties were tested using two different methods. The total phenolic and total flavonoid content ranged from 0.897 to 4.226 mg GAE g−1 dw and from 0.238 to 4.626 mg rutin g−1 dw, respectively. Flavonoids — rutin, quercetin, and hydroxybenzoic acids — gallic, protocatechuic, vanillic and syringic were identified and quantified. Rutin was the most abundant flavonoid and protocatechuic acid was the most abundant phenolic acid in evaluated cultivars. All cultivars showed significant antiradical properties, but their chelating activity was weak. The German cultivar of tartary buckwheat Lifago had significantly higher phenolic content and better antioxidant properties than other cultivars. The content of rutin was 24 times higher and free radicals scavenging activity about 70 % higher than the average value of other cultivars.
Antioxidant properties of curcuminoids isolated from Curcuma longa L.
Authors: Mošovská Silvia , Petáková Patrícia , Kaliňák Michal , Mikulajová Anna 
Published: December 2016

Abstract
The evaluation of antioxidant potential of food has received much attention in recent years. Antioxidant compounds can scavenge free radicals and thereby can protect the human body from free radicals. This study was focused on the isolation of curcuminoids from the dried turmeric rhizome, and studying their antioxidant activity. The presence of curcuminoids was identified in turmeric sample by Nuclear Magnetic Resonance (NMR) analysis. Since neutral curcumin is known to be poorly soluble, the synthesis of curcumin-cyclodextrin and curcumin-phospholipid complexes was also performed. The antioxidant activity of isolated curcuminoids was assessed by two methods (ABTS and FRAP assay) and their scavenging activities were compared with those of prepared complexes. The ability to reduce ABTS radical cation decreased as follows: quercetin > trolox > curcuminoids > curcumin-cyclodextrin complex > curcumin-phospholipid complex. The reducing potential of tested samples in descending order was quercetin > trolox > curcumin-cyclodextrin complex > curcuminoids > curcumin-phospholipid complex.
Comparison of different absorption corrections on the model structure of tetrakis(μ2-acetato)-diaqua-di-copper(II)
Authors: Koziskova Julia , Hahn Friedemann , Richter Jens , Kožíšek Jozef 
Published: December 2016

Abstract
Two different absorption correction methods were compared in order to find out which method is preferable to improve solving and refining a crystal structure. Experiments were performed on the crystal of a tetrakis(μ2-acetato)-diaqua-di-copper(II) complex. The first correction method used was the numerical absorption correction with the aid of a crystal-shape model, and the other was the semi-empirical one, applying scaling routines to the intensity data.
Electrical conductivity of molten fluoride-oxide melts with high addition of aluminium fluoride
Authors: Kubiňáková Emília , Híveš Ján , Danielik Vladimír 
Published: December 2016

Abstract
Electrical conductivity of NaF-AlF3 melts with an addition of 2 wt % Al2O3 and/or 5 wt % CaF2 was measured using a pyrolytic boron nitride tube-type cell with a constant distance of electrodes. The molar cryolite ratios MR = n(NaF)/n(AlF3) were 1.8 and 1.6, and the temperature was varied from 865 °C to 1005 °C. Ac-techniques with a sine wave signal with small amplitude in the high frequency range were applied. Electrolyte resistance was obtained from nonlinear regression analysis according to equivalent circuit. Experimental data were used to describe the dependence of the electrical conductivity in fluoride melts with lower temperature on the amount of various additions and temperature.
Electrochemical method for point-of-care determination of ciprofloxacin using boron-doped diamond electrode
Authors: Cinková Kristína , Andrejčáková Dana , Švorc Ľubomír 
Published: December 2016

Abstract
This paper presents an electrochemical behavior study and quantification of fluoroquinolone antibiotic ciprofloxacin using boron-doped diamond electrode. Ciprofloxacin provides a diffusion-driven electrode reaction with an irreversible and poorly defined peak at +1.6 V vs. Ag/AgCl electrode in the presence of Britton-Robinson buffer solution pH 4. Applying differential pulse voltammetry (modulation amplitude of 60 mV, modulation time of 50 ms), the calibration curve with high linearity (R
2 = 0.997) was obtained within the concentration range of (0.74 – 20.0) × 10−6 mol L−1 with the detection limit of 6.0 × 10−7 mol L−1 and repeatability expressed by relative standard deviation of 2.7 % (for 20 measurements). Interference study was performed to explore the selectivity of the elaborated procedure. By analysis of pharmaceutical dosages and model human urine samples, the ciprofloxacin content with the recovery values ranging from 88.4 to 121.2 % were determined. The developed approach using point-of-care electrochemical sensor based on boron-doped diamond material could represent inexpensive analytical alternative to separation methods and could be beneficial in analysis of biological samples and in the quality control in pharmaceutical industry.
An efficient and accurate method to calculate diffusion coefficient of structured particles. A first case study of Pb diffusion in rare gases
Authors: Matúška Ján 
Published: December 2016

Abstract
Diffusion coefficient depends on temperature, pressure, reduced mass of colliding particles and collision cross section. The presented method is designed to calculate the diffusion coefficient in loose systems containing molecules with relatively complicated colliding trajectories. It is a combination of the Chapman-Enskog theory and the molecular dynamics calculation. The Chapman-Enskog theory provides the relation between the diffusion coefficient and the collision cross section which is the result of multiple integration of the scattering angle of all possible initial conditions of the collision. The scattering angle is obtained by numerical integration of the Newton’s equation of motion with previously selected initial conditions. The proposed method has been verified for the simple system of a lead atom diffusion in rare gases and the results were compared to those of two other theoretical methods.
Effect of light emitting diodes with different color temperatures on immune responses and growth performance of male broiler
Authors: Sharideh Hossein , Zaghari Mojtaba 
Published: December 2016

Abstract
The aim of the present study was to evaluate the effects of the different color temperatures (Kelvin; K) of the light emitting diodes (LEDs) on broiler chicken health and growth performance compared to incandescent (ICD) light bulbs. Three hundred and sixty one-day-old Ross 308 male chicks were tested for 42 days. The chicks were randomly distributed into three treatment groups [neutral-white (4,286 K), warm-white (2,990 K), and ICD (2,790 K) light bulbs] of 120 chicks/treatment with six replicates each by adopting complete randomized design. The diets were similar for all treatment groups. The live body weight and feed intake were recorded weekly and feed conversion ratio (FCR) was calculated (weekly and whole period). Indices of humoral immunity [antisheep red blood cell (SRBC) titer, IgG, and IgM at 26 and 34 days of age], Newcastle disease (ND) virus and avian influenza (AI) virus antibody at 40 days of age, cell-mediated immunity [cutaneous basophilic hyper-sensitivity (CBH) response at 41 days of age)] as well as total and differential leukocyte numbers at 42 days of age) were measured. Effects of different color temperatures of the LEDs and ICD light bulbs on body weight, feed consumption, and FCR were not statistically significant (P>0.05). Also, the effect of color temperatures of light on secondary titers of SRBC, AI antibody response, CBH response, the total number of leukocytes and percentage of lymphocytes were not significant. However, the different color temperatures of LEDs have a significant effect on primary SRBC and ND antibody titers (P≤0.05). The highest primary SRBC (P≤0.05) and ND (P≤0.05) antibody titers were observed in warm-white light. It was concluded that based on the 3 color temperatures examined, it seems that the most suitable to provide the optimum level of immunity and energy-saving in commercial broiler houses is warm-white light.
Use of α-resolvable designs in the construction of two-factor experiments of split-plot type
Authors: Ozawa Kazuhiro , Kuriki Shinji , Mejza Stanisław 
Published: December 2016

Abstract
We consider an incomplete split-plot design (ISPD) with two factors generated by the semi-Kronecker product of two α-resolvable designs. We use an α-resolvable design for the whole plot treatments and an affine α-resolvable design for the subplot treatments. We characterize the ISPDs with respect to the general balance property, and we give the stratum efficiency factors for the ISPDs.
Kidney Transplantation Program in Montenegro
Authors: Ratkovic Marina , Jukic Nikolina Basic , Radunovic Danilo , Prelevic Vladimir , Gledovic Branka 
Published: December 2016

Abstract

Introduction. There was no transplantation program in Montenegro until 2012. On the other hand, there were 93 patients with transplanted kidney. These transplantations were performed abroad; 15% in areas of black organ markets (India, Pakistan, Russian Federation). Beside the ethical problems, these transplantations carried a high risk of complications.

Methods. Our health system had to ensure solution for patients with terminal organ failure. Preparation of all neccessary conditions for the beginning of transplantation program in Montenegro started in 2006 with different activities including public, legal, medical, educational and international cooperation aspects.

Results. The first kidney transplantation from living donor in Montenegro was preformed on September 25th, 2012. In the period from 2012 until now 23 kidney transplantations from living related donor were performed and one kidney transplantation from deceased donor in the Clinical Center of Montenegro. In the a two year-follow-up period, all patients to whom kidney transplantation was performed are in a good condition and without serious complications in posttransplant period.

Conclusion. Development of the transplantation program allowed controlled transplantation and safety of patients. Our next steps are development of deceased organ donor transplantation and achievement of higher rate of deceased donor organ transplantation and individualization of immunosuppressive therapy.
Association Between Hypertension and Residual Renal Function in Hemodialysis Patients
Authors: Ajanovic Selma , Resic Halima , Masnic Fahrudin , Coric Aida , Beciragic Amela , Prohic Nejra , Dzubur Alen , Tomic Monika 
Published: December 2016

AbstractIntroduction.Cardiovascular diseases are the leading cause of death in hemodialysis patients. The decline of residual renal function increases the prevalence and severity of risk factors of cardiovascular morbidity and mortality in these patients. Hypertension is common in dialysis patients and represents an important independent factor of survival in these patients.Methods.The study included 77 patients who are on chronic HD for longer than 3 months. Depending on the measured residual diuresis patients were divided into two groups. The study group consisted of patients with residual diuresis >250 ml/day, while patients from control group had residual diuresis <250 ml/day. All patients had their blood pressure measured before 10 consecutive hemodialysis treatments. Collected data were statistically analyzed using SPSS 16.0.Results.The study included 77 hemodialysis patients, mean age of 56.56±14.6 years and mean duration of hemodialysis treatment of 24.0 months. Of the total number of patients, 39(50.6%) had preserved residual renal function. Hypertension was more common in the group of patients who did not have preserved residual renal function (68.4% vs 25.6%). There was statistically significant negative linear correlation between the volume of residual urine output and the residual clearance of urea and values of systolic blood pressure [(rho=−0.388; p<0.0001); (rho=−0.392; p<0.0005)], values of mean arterial pressure [(rho =−0.272; p<0.05); (rho=−0.261; p=0.023; p<0.05)] and values of pulse pressure in hemodialysis patients [(rho =−0.387; p<0.001); (rho=−0.400; p<0.0005)].Conclusions.Residual renal function plays an important role in controlling blood pressure in patients on hemodialysis. More attention should be directed to preserve residual renal function, and after the start of hemodialysis by avoiding intensive ultrafiltration with optimal antihypertensive therapy.
Idiopatic Systemic Capillary Leak Syndrome Treated Successfully with High-Dose Intravenous Immunoglobulins
Authors: Ekinci Ferhat , Soyaltın Utku Erdem , Akar Harun , Ugur Mehmet Can , Ersoy Ercan , Komac Andac , Yildirım Tuba Demirci 
Published: December 2016

Abstract
Idiopathic systemic capillary leak syndrome (ISCLS) is characterized by a triad of hypotension, hemoconcentration and hypoalbuminemia due to a shift of intravascular fluid and albumin to the extravascular area. We describe a hypovolemic patient with hemoconcentration and hypoalbuminemia who was successfully treated with high-dose intravenous immunoglobulins (IVIG). The purpose of this case report is to discuss the clinical management of idiopathic systemic capillary leak syndrome on the background of relevant literature review.
Solution of Fire Protection in Historic Buildings
Authors: Iringová Agnes , Idunk Róbert 
Published: December 2016

Abstract
The paper introduces optimization of the functional use of renovated spaces in historic buildings in terms of fire risk. It brings assessment of fire protection in the folk house Habánsky Dvor, situated in the village of Veľké Leváre, whose function was changed into the museum. It goes into static analysis of existing load-bearing structures and assessment of their fire resistance according to Eurocodes.
Laboratory Measurements of Particulate Matter Concentrations from Asphalt Pavement Abrasion
Authors: Fullová Daša , Đurčanská Daniela 
Published: December 2016

AbstractThe issue of emissions from road traffic is compounded by the fact that the number of vehicles and driven kilometres increase each year. Road traffic is one of the main sources of particulate matter and traffic volume is still increasing and has unpleasant impact on longevity of the pavements and the environment. Vehicle motions cause mechanical wearing of the asphalt pavement surface - wearing course by vehicle tyres. The contribution deals with abrasion of bituminous wearing courses of pavements. The asphalt mixtures of wearing courses are compared in terms of mechanically separated particulate matter. The samples of asphalt mixtures were rutted in wheel tracking machine. The particulate matter measurements were performed in laboratory conditions. The experimental laboratory measurements make it possible to sample particulates without contamination from exhaust emissions, abraded particles from vehicles, resuspension of road dust and climate affects. The contribution offers partial results of measurements on six trial samples of asphalt mixtures with different composition. It presents particulate matter morphology and the comparison of rutted asphalt samples in terms of PM mass concentrations and chemical composition.
Proportions - Disposition Relationship Analysis of a Historical Truss in a Rural House in Vápenná Village, Czech Republic
Authors: Krušinský Peter , Capková Eva , Augustinková Lucie , Korenková Renáta 
Published: December 2016

Abstract
We have analysed historical trusses based on previous building-historical researches, particularly focusing on sacral buildings, in chosen regions of Slovakia, with one of the primary goals to examine geometric concepts and proportional relationships used for their construction. The knowledge of proportional principles and relationships used in various historical sacral trusses, additionally supported by contemporary literature, was applied to a village house truss from 1774 in Vápenná, Jeseníky district of the Czech Republic.
Sympathectomized tumor-bearing mice survive longer but develop bigger melanomas
Authors: Horvathova L , Tillinger A , Padova A , Mravec B 
Published: December 2016

AbstractObjectives.Previously we have shown that 20 days after the tumor cells injection smaller melanomas have been developed in chemically sympathectomized mice in comparison with animals having intact sympathetic nervous system. However, it is known that chemical sympathectomy reduces the sympathetic neurotransmission only temporarily. In the present study, we monitored the survival of the sympathectomized mice with melanoma with an attempt to find out how long the suppressing effect of sympathectomy on the melanoma growth may endure.Methods.The chemical sympathectomy was performed by intraperitoneal injection of neurotoxin 6-hydroxydopamine in male C57BL/6J mice. Seven days later, the animals were injected subcutaneously with B16-F10 melanoma cells. Then, melanoma development, survival of the tumor-bearing mice and weight of the developed tumor mass were analyzed.Results.Sympathectomy delayed the development of the palpable tumors (18th day vs.14th day) and significantly prolonged the survival of the tumor-bearing mice (median 34 days vs. 29 days). However, the weight of the developed melanoma was significantly increased in the sympathectomized mice in comparison with the animals having intact sympathetic nervous system.Conclusions.The data of the present study showed that effect of the chemical sympathectomy, performed before the tumor growth induction, persisted even at the time when sympathetic nerves started to regenerate that resulted in a prolonged survival of the mice with melanoma. However, comparing to our previous study, in which we have shown a reduced tumor mass in earlier stages of the tumor growth, specifically 20 days after melanoma cells injection, now we indicate that in later stages of the melanoma progression, the tumor mass was significantly increased in sympathectomized animals. These contra-intuitive findings may indicate that interventions affecting the sympathetic nervous system may exert complex effect on the tumor progression. Based on these data we may suggest that the potential therapeutic interventions affecting the sympathetic signaling in the tumor tissue and its microenvironment should attenuate the sympathetic neurotransmission not only temporarily but till the complete regression of the tumor tissue.
A case of hypercalcaemic crisis secondary to coexistence of primary hyperparathyroidism and Graves’ disease
Authors: Baldane S , Ipekci SH , Evcen R , Gedik GK , Guler I , Kebapcilar L 
Published: December 2016

Abstract
A 46 year-old female patient presented to the hospital with ongoing and progressively increasing fatigue, severe nausea and vomiting, loss of appetite, constipation, palpitations and somnolence. Laboratory evaluation revealed a severe hypercalcaemia and overt hyperthyroidism. She was diagnosed with primary hyperparathyroidism accompanied by Graves’ disease. The patient underwent total thyroidectomy and right inferior parathyroid gland adenoma excision on the 24th day of her admission to the hospital after calcium levels and free thyroid hormone levels were brought to normal ranges. We suggest that a possibility of simultaneous thyrotoxicosis and primary hyperparathyroidism in cases presenting with a hypercalcaemic crisis should be considered