bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tartrate‐Anchored Tetranuclear Titanium‐Oxo Clusters Functionalized by Chromophore Ligands Exhibiting Photoelectric Response and Photodegradation Performances of Methylene Blue
Authors: Wang Yali , Yao Boxin , Xie Bin , He Yi , Lai Chuan , Liu Mengnan , Feng Jianshen , Mou Wenyu , Zheng Zhixi 
Published: September 2024

ABSTRACTIn recent years, researchers have devoted considerable effort to the study of high crystalline titanium‐oxo clusters (TOCs), because TOCs are considered to be the molecular analogs of TiO2 nanoparticles and have the potential to be utilized as effective cleaning and catalytic materials. Two new tartrate‐anchored tetranuclear TOCs functionalized with chromophore ligand of p‐nitrobenzoate (NB)/p‐toluenesulfonate (TS), namely, [Ti4(TA)(NB)2(OiPr)10] (1, H4TA = tartaric acid) and [Ti4(TA)(TS)2(OiPr)10] (2), were synthesized and their structures were characterized by various methods. The molecular structure analyses indicated that 1 and 2 are all tetranuclear {Ti4} TOCs, in which tartrate appears as a hexadentate μ4‐bridging ligand while p‐nitrobenzoate/p‐toluenesulfonate acts as a bidentate μ2‐bridging ligand. TOCs 1 and 2 are of good thermal and solvent stability. Furthermore, their photocurrent responses and photocatalytic degradation activities towards methylene blue (MB) were also investigated. In the presence of H2O2, the photocatalytic degradation efficiencies of MB by 1 and 2 are about 84.43% and 71.00%, respectively, at room temperature under visible light irradiation for 60 min. These findings shed light on designing efficient polycarboxylate‐based TOCs photocatalysts.
Development of molecularly imprinted nanoparticles for the detection of cardiovascular diseases biomarker Angiotensin II in human serum
Authors: Arısoy Pırıl , Baydemir Peşint Gözde 
Published: September 2024

AbstractAngiotensin II (Ang II) is a peptide hormone that causes vasoconstriction and an increase in blood pressure. Due to its relationship with cardiovascular diseases, it is an important biomarker in blood serum. In this study, Ang II imprinted nanoparticles were synthesized by miniemulsion polymerization reaction for the determination of Ang II from human serum. Hydroxyethyl methacrylate (HEMA) based Ang II imprinted (Ang II‐MIPnp) and non‐imprinted nanoparticles (NIPnp) were synthesized, characterized by zeta size analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transform infrared spectrophotometer (FTIR‐ATR). The average particle size of the NPs was recorded as 50 nm. Ang II molecules were successfully removed from the Ang II‐MIPnp with a 98% success rate using 0.5 M NaCl solution to obtain template‐specific cavities. Then, the adsorption studies were achieved. The binding capacity was found as 4500 pg. g−1 at 700 pg. mL−1 Ang II concentration. The selectivity studies showed that Ang II‐MIPnp can recognize Ang II molecules 2.76 times and 3.23 times selectivity than Ang I and Vsp respectively. Reusability studies shows that the synthesized nanomaterial is reusable.
Coating of mussel‐inspired PDA modified SiC whiskers for enhancing the mechanical properties of SLS‐formed TPU parts
Authors: Xie Fenghui , Wu Wei , Hu Huanbo , Ye Junjian , Cui Lu , Wang Zhengyi , Zhang Wenxue 
Published: September 2024

AbstractIn order to enhance the mechanical properties of lattice structure parts made of thermoplastic polyurethane elastomer (TPU) prepared by selective laser sintering (SLS) technology, this study employed the oxidative self‐polymerization of dopamine (DA) to prepare polydopamine‐modified silicon carbide whiskers (PDA‐SiC) fillers with a core‐shell structure. These fillers were uniformly dispersed in a waterborne polyurethane (WPU) to form a coating solution, which was then used to prepare TPU printed parts with a uniform PDA‐SiC/WPU coating structure through post‐treatment impregnating‐curing processes. The coated TPU parts exhibited tensile strength, elongation at break, and room temperature compressive strength of 8.37 MPa, 610.2%, and 1.062 MPa, respectively, representing improvements of 40.9%, 33.2%, and 353.3% compared to pure TPU parts. This approach effectively enhanced the mechanical performance of SLS‐formed TPU parts, strengthening their application in the field of flexible lattice structure parts.
Balancing thermal conductivity, dielectric, and tribological properties in polyamide 1010 with 2D nanomaterials
Authors: Pinto Gabriel M. , Staffa Lucas , Helal Emna , Hahn Carolina , Vieira Lúcia , Ribeiro Hélio , David Eric , Demarquette Nicole R. , Fechine Guilhermino J. M. 
Published: September 2024

AbstractLow electrical conductivity and high heat dissipation are crucial for electronic packaging materials. Additionally, friction is critical for the lifespan and energy efficiency of components. To address these requirements, polymer nanocomposites based on bio‐based polyamide 1010 and ultra‐low contents of 2D nanomaterials were produced by melt‐blending. Graphene oxide, hexagonal boron nitride, and molybdenum disulfide were selected for their two‐dimensional structure and electrical insulation, providing high thermal conductivity while preserving the polymer's dielectric nature. Hybrid nanocomposites were also produced to explore potential synergistic effects. Results showed all compositions maintained the polymer's intrinsic dielectric properties. Although the friction coefficient increased slightly compared with neat polyamide, all nanocomposites remained within the low‐friction range required for low‐friction materials. Thermal conductivity improved by 5%–10% compared with unfilled polyamide, with hybrid systems performing slightly better, indicating a minor synergistic effect. Despite these enhancements being modest compared with the literature, achieving high thermal conductivity usually requires over 20 wt% of nanofiller, which is detrimental to mechanical performance. In this study, at most 0.5 wt% was used, with composites being obtained directly through melt‐blending. This highlights their potential as low‐content additives for thermal interface materials without compromising other essential properties.
Sleep disturbance and other co‐occurring conditions in autistic children: A network approach to understanding their inter‐relationships
Authors: Richdale Amanda L. , Shui Amy M. , Lampinen Linnea A. , Katz Terry 
Published: September 2024

AbstractAutistic children frequently have one or more co‐occurring psychological, behavioral, or medical conditions. We examined relationships between child behaviors, sleep, adaptive behavior, autistic traits, mental health conditions, and health in autistic children using network analysis. Network analysis is hypothesis generating and can inform our understanding of relationships between multiple conditions and behaviors, directing the development of transdiagnostic treatments for co‐occurring conditions. Participants were two child cohorts from the Autism Treatment Network registry: ages 2–5 years (n = 2372) and 6–17 years (n = 1553). Least absolute‐shrinkage and selection operator (LASSO) regularized partial correlation network analysis was performed in the 2–5 years cohort (35 items) and the 6–17 years cohort (36 items). The Spinglass algorithm determined communities within each network. Two‐step expected influence (EI2) determined the importance of network variables. The most influential network items were sleep difficulties (2 items) and aggressive behaviors for young children and aggressive behaviors, social problems, and anxious/depressed behavior for older children. Five communities were found for younger children and seven for older children. Of the top three most important bridge variables, night‐waking/parasomnias and anxious/depressed behavior were in both age‐groups, and somatic complaints and sleep initiation/duration were in younger and older cohorts respectively. Despite cohort differences, sleep disturbances were prominent in all networks, indicating they are a transdiagnostic feature across many clinical conditions, and thus a target for intervention and monitoring. Aggressive behavior was influential in the partial correlation networks, indicating a potential red flag for clinical monitoring. Other items of strong network importance may also be intervention targets or screening flags.
Multivariate Scalar on Multidimensional Distribution Regression With Application to Modeling the Association Between Physical Activity and Cognitive Functions
Authors: Ghosal Rahul , Matabuena Marcos 
Published: September 2024

ABSTRACTWe develop a new method for multivariate scalar on multidimensional distribution regression. Traditional approaches typically analyze isolated univariate scalar outcomes or consider unidimensional distributional representations as predictors. However, these approaches are suboptimal because (i) they fail to utilize the dependence between the distributional predictors and (ii) neglect the correlation structure of the response. To overcome these limitations, we propose a multivariate distributional analysis framework that harnesses the power of multivariate density functions and multitask learning. We develop a computationally efficient semiparametric estimation method for modeling the effect of the latent joint density on the multivariate response of interest. Additionally, we introduce a new conformal prediction algorithm for quantifying the uncertainty of our multivariate predictions based on subject characteristics and individualized distributional predictors, providing valuable insights into the conditional distribution of the response. We validate the effectiveness of our proposed method through comprehensive numerical simulations, clearly demonstrating its superior performance compared to traditional methods. The application of the proposed method is demonstrated on triaxial accelerometer data from the National Health and Nutrition Examination Survey 2011–2014 for modeling the association between cognitive scores across various domains and distributional representation of physical activity among the older adult population. Our results highlight the advantages of the proposed approach, emphasizing the significance of incorporating multidimensional distributional information in the triaxial accelerometer data.
Mediating effects of rumination on insomnia in cancer survivors: Influences of cancer‐related fatigue, fear of recurrence, and psychological distress
Authors: Amani Omid , Mazaheri Mohammad Ali , Malekzadeh Moghani Mona , Zarani Fariba , Hamidi Choolabi Rasool 
Published: September 2024

AbstractBackgroundWhile advancements in cancer treatments have improved survival rates, they also lead to adverse effects such as insomnia, which significantly impacts survivors' sleep quality.ObjectiveThis study explores the influence of cancer‐related fatigue (CRF), Fear of Cancer Recurrence (FCR), and psychological distress, with rumination serving as a mediating factor, on the insomnia experienced by cancer survivors.MethodsThe study involved 220 cancer survivors attending Shohada‐e‐Tajrish Hospital's oncology center in Tehran, Iran. Participants were selected through convenience sampling and completed several questionnaires: the Insomnia Severity Index, Fear of Cancer Recurrence Inventory, Cancer Fatigue Scale, Kessler Psychological Distress Scale, and Rumination Response Scale.ResultsThe results showed that the tested model had a good fit, and the correlation matrix demonstrated significant positive correlations between CRF (0.46), FCR (0.15), psychological distress (0.55), and rumination (0.42) with insomnia in cancer survivors (p < 0.05). Notably, CRF (B = 0.356, p < 0.001) and psychological distress (B = 0.339, p < 0.001) affect insomnia both directly and indirectly through mediation by rumination, while the impact of FCR on insomnia was indirectly significant (B = 0.73, p < 0.05).ConclusionThe findings suggest that interventions focused on managing rumination could be potential targets to alleviate insomnia and improve the sleep quality of cancer survivors.
Erucic acid increases the potency of cisplatin‐induced colorectal cancer cell death and oxidative stress by upregulating the TRPM2 channel
Authors: Nazıroğlu Ayşenur , Çarhan Ahmet , Nazıroğlu Mustafa 
Published: September 2024

AbstractErucic acid (ErA) is a source of omega‐9 monounsaturated fatty acids. ErA exhibited antitumor effects by causing apoptosis and oxidative stress in tumor cells, with the exception of the HT‐29 human colorectal cancer cell line. The apoptotic and Ca2+ signaling pathways in tumor cells are triggered when mitochondrial Ca2+ and Zn2+ accumulation produce reactive free oxygen species (ROS), which in turn activate TRPM2. ErA‐induced ROS and TRPM2 stimulation may augment the anticancer action of cisplatin (CSP). We aimed to study the effects of ErA and CSP incubations on ROS, apoptosis, and cell death in the HT‐29 cells by activating TRPM2. The cells were divided into five groups: control, ErA (200 µM for 48 h), CSP (25 µM for 24 h), and ErA + CSP + TRPM2 antagonists (200 µM carvacrol and 25 µM N‐(p‐amylcinnamoyl)anthranilic acid for 24 h). The TRPM2 antagonists reduced ErA plus CSP‐induced increases in H2O2‐induced intracellular free Ca2+ concentration ([Ca2+]c) and adenosine diphosphate‐ribose‐caused TRPM2 currents. ErA and CSP were found to cause apoptosis and cell death by raising the intracellular free Zn2+ concentration (Zn2+]c), caspase‐3, −8, and −9, mitochondrial membrane dysfunction, and ROS, while lowering reduced glutathione, cell viability, and cell number. The oxidative, apoptotic, and tumor cell death effects of CSP in the cells were enhanced by the increase of ErA‐mediated [Ca2+]c and Zn2+]c entering mitochondria through the activation of TRPM2. In conclusion, we observed that the combination of ErA and CSP was synergistic via TRPM2 activation for the treatment of HT‐29 tumor cells.
Hypocalcemic cardiomyopathy with heart failure: A rare Case report
Authors: Kharel Manish , Subedi Anukul , Hossain Md Fahad 
Published: September 2024

Key Clinical MessageHypocalcemia is one of the rarest causes of reversible cardiomyopathy. Patients with refractory heart failure need to be explored for hypocalcemia and need prompt correction.AbstractHypocalcemia is a rare cause of reversible dilated cardiomyopathy. Correction of calcium is crucial to recover left ventricular function and structure. We presented the case of a 55‐year‐old female who was admitted to the hospital with refractory heart failure due to hypocalcemia induced by primary hypoparathyroidism and complicated by vitamin D deficiency. The patient's cardiac symptoms improved dramatically upon correction of hypocalcemia, and vitamin D. Therefore, the key clinical message of this case report is, that hypocalcemia, although rare, should be considered as one of the differential diagnoses when heart failure is refractory and early diagnosis and treatment is necessary as it is the cause of reversible cardiomyopathy and could reduce morbidity and mortality.
One‐Pot Divergent Synthesis of a 13‐Ring Triquinone and its Facile Conversion to a [4.4.4]Tridecastarphene
Authors: Geng Hao , Kopreski Ryan P. , Liu Qian , Briggs Jonathan B. , Miller Glen P. 
Published: September 2024

AbstractAcenes are notable for their optoelectronic properties and applications in organic electronics. Starphenes are structurally related molecules possessing three acene arms that radiate linearly from a central benzene ring (i. e., linearly annellated triphenylenes). Large starphenes have been prepared using convergent syntheses involving transition metal catalyzed cyclotrimerizations of either preformed acenes or arynes. Here, we report a one‐pot divergent synthesis of a 13‐ring triquinone that is readily converted to a [4.4.4]tridecastarphene derivative. The one‐pot procedure involves the sequential reactions of three 1,4‐anthraquinones with o‐quinodimethane derivatives that are generated sequentially from a stable, trisulfone precursor. The resulting [4.4.4]tridecastarphene derivative bearing p‐(t‐butyl)phenyl substituents was characterized by 1H NMR, 13C NMR and UV‐vis spectroscopies, as well as mass spectrometry, cyclic voltammetry and differential pulse voltammetry. Theoretical and experimental studies reveal a relatively high‐lying HOMO orbital (about −4.70 to −4.86 eV) and a relatively small HOMO‐LUMO gap (2.1 eV), suggesting utility as a p‐type organic semiconductor. Our [4.4.4]tridecastarphene derivative photooxidizes in a CH2Cl2 solution exposed to ambient light and air with a half‐life of 150 minutes at room temperature, but shows no sign of degradation after 12 months in the solid‐state. Our [4.4.4]tridecastarphene derivative also shows excellent solubility in a number of organic solvents including dichloromethane, chloroform and toluene, potentially enabling printed electronic applications.
Synthesis and Biological Evaluation of Deoxycyclophellitols as Human Retaining β‐Glucosidase Inhibitors
Authors: Radchenko Yevhenii , Su Qin , Schröder Sybrin S. , van Gijlswijk Luke , Artola Marta , Aerts Johannes M. F. G. , Codée Jeroen D. C. , Overkleeft Herman S. 
Published: September 2024

AbstractCyclophellitol is a potent and selective mechanism‐based retaining β‐glucosidase inhibitor that has served as a versatile starting point for the development of activity‐based glycosidase probes (ABPs). We developed routes of synthesis of eight mono‐ and dideoxycyclophellitols and cyclophellitol aziridines, the latter as ABPs carrying either a biotin or fluorophore linked to the aziridine nitrogen. We reveal the potency of these 24 compounds as inhibitors of the three human retaining β‐glucosidases, GBA1, GBA2 and GBA3. We show that 3,6‐dideoxy‐β‐galacto‐cyclophellitol aziridine selectively captures GBA3 over GBA1 and GBA2 in extracts of cells overexpressing both GBA2 and GBA3. We also identify a probe that selectively labels GBA1 and GBA2 over GBA3 at lower concentrations. In sum, the here‐presented studies reveal new chemistries to prepare chiral, substituted cyclitol epoxides and aziridines, add to the growing suite of cyclophellitols varying in configuration and substitution pattern, and yielded a reagent that may find use to investigate the physiological role and therapeutic relevance of the most elusive of the three retaining β‐glucosidases: GBA3.
CrMn‐based catalysts for oxidative dehydrogenation of propane to propylene with CO2
Authors: Moniri Armin , Badoga Sandeep , Ali Mohamed , Chen Jinwen 
Published: September 2024

AbstractThe paper investigates the catalytic oxidative dehydrogenation of propane with carbon dioxide (ODH‐CO2) as a promising route for propylene production, an avenue yet to be commercially developed. Utilizing the incipient wetness catalyst preparation method, CrMn catalysts were synthesized on three supports (γ‐Al2O3, ZSM‐5, and SBA‐15). Comprehensive characterization through Brunauer–Emmett–Teller (BET) analysis, X‐ray diffraction (XRD), thermogravimetric analysis (TGA), transmission electron microscopy (TEM)/scanning transmission electron microscopy (STEM)‐energy‐dispersive X‐ray spectroscopy (EDS), and hydrogen temperature programmed reduction (H2‐TPR) was conducted to comprehend catalyst behaviour. Among the six catalysts tested, Cr/SBA‐15 was exhibited as the best performer, achieving propane and CO2 conversions of 36.2% and 14.1%, respectively, with a propylene selectivity of 33.4%. Over a 50‐h time on stream (TOS), it demonstrated gradual declines in conversions while retaining 75% of initial values. The incorporation of manganese as a promoter effectively mitigated coke formation, albeit with slight reductions in propane conversion and propylene selectivity.
Bioremediation of Toxic Metals Using Aquatic Macrophytes: Challenges and Opportunities
Authors: Singh Salam Suresh , Meitei Maibam Dhanaraj , Upadhyay Keshav Kumar , Chanda Rajdeep , Mawi Ramthar , Singh Ngangbam Somen , Brearley Francis Q. , Tripathi Shri Kant 
Published: September 2024

ABSTRACTEnvironmental pollution caused by urbanization, agricultural intensification, and industrialization has led to an increase in the disposal of toxic effluents in aquatic environments. Most ecosystems in the world receive a variety of toxic metals (TMs) that exceed the capacity of water bodies to absorb or recycle them, thereby threatening aquatic and human life. Physicochemical remediation methods encounter problems because of the high cost, labor input, and use of chemicals with long residence times that later add toxic by‐products. However, bioremediation techniques are a safe option for mitigating environmental pollution because of their high efficiency, cost‐effectiveness, non‐intrusiveness, eco‐friendliness, ease of application, and social acceptance. Submerged and free‐floating macrophytes were found to be more effective in the bioaccumulation of TMs than emergent macrophytes. Furthermore, most studies have suggested the use of macrophytes for the removal of TMs from water bodies; however, studies on the management of phytoremediated biomass are scarce. This review demonstrates the role of various macrophytes for the removal of TMs from water bodies and suggests techniques for the disposal and recycling of phytoremediated biomass with accumulated TMs. Further, the applications of genetically modified plants, nanotechnology, and native hyperaccumulators have been suggested as suitable candidates for greater efficiency of phytoremediation and appropriate management of TMs in the environment in the future.
A call for action: Insights from the pre‐COP28 scholarly discourse and beyond the operationalization of the Loss and Damage Fund
Authors: Shumba Dorcas Stella 
Published: September 2024

AbstractThis paper conducts a semisystematic literature review from 2021 to 2023, focusing on loss and damage (L&D). Drawing upon the works of various scholars, it synthesizes critical concerns raised in the literature and assesses whether these concerns were addressed by the Transitional Committee's report on the operationalization of the new funding arrangements for responding to loss and damage, as outlined in COP 28 decisions 1/CP.28 and 5/CMA.5. By analyzing scholarly discussions on L&D leading up to COP 28, the study gauges the extent to which academic concerns have been addressed and identifies areas requiring improvement for better management of climate change‐induced L&D effects. The findings provide valuable insights for ongoing deliberations on the Loss and Damage Fund (LDF), offering guidance for policymakers as they address these challenges. Additionally, the paper informs future policy directions to ensure responsiveness to the needs of communities affected by climate change‐induced L&D. Lastly, the study contributes to ongoing scholarly dialogues by laying the groundwork for future research endeavors in this critical area.
Electrooxidative C(sp3)−H Cyanation of Sparteine and Lupanine in Undivided Batch and Continuous‐Flow Cells
Authors: Durão Raquel M. , Clemente Duarte B. , Muiz Abdullahi A. , Lima Sara , Carvalho Daniel F. , De Vos Stijn , de Jesus Rita , Fortuna Andreia , Afonso Carlos A. M. , Coelho Jaime A. S. 
Published: September 2024

AbstractSparteine is widely used as a chiral ligand in asymmetric synthesis, but methods for providing efficient access to functionalized sparteine derivatives are still limited. Herein, we describe an electrochemical α‐cyanation of sparteine‐type bis‐quinolizidine alkaloids. This method features commercially available setups for batch and single‐pass continuous flow conditions, enabling easy gram scale synthesis of valuable racemic and enantiopure products. Moreover, insights into the selectivity of the reaction and overoxidation mechanisms are disclosed. This allows for the development of divergent oxidation pathways depending on the electrolysis conditions.