bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Utilization Dynamic Temperature Modeling: A Case Study in High Temperature Well Planning
Authors: Suryadi Hendrik , Van Chinh Phan 
Published: November 2016

Extended Abstract
Today, oil and gas industries have been continuously drilling into deeper reservoirs and into high temperature formations. Drilling high temperature wells poses new challenges with current available drilling tools because the operating temperatures can closely reach and at times, surpass downhole tools' temperature specifications. The temperature will affect electronics, elastomer or rubber components in tools, sensors, or even could reduce the mechanical strength of the steel collar and cause twist-off. The development of downhole tool technology continues to strengthen and increase the tool temperature rating to withstand those challenges. Utilizing high temperature rated downhole tools can be significantly expensive compared to standard temperature rating tools (150oC). Other technological developments for high temperature wells rely on mud properties and mud surface cooling system. Despite that, one of the key factors to successful drilling operations in high temperature wells still lies on the capability to simulate downhole conditions taking account various technologies and parameters involved, understand the potential challenge and risks, and predict down-hole circulating temperatures that tools will be exposed to.
Development of a DSS and Online Tools to Support Sleep Disorder Consultations using Design Science.
Authors: Blake Jacqueline , Kerr Don , Gammack John 
Published: November 2016

Medical decision making takes place in a complex and dynamic environment, involving various individual and organisational stakeholders. In such contexts supportive information systems are required to be designed for practical efficacy, emphasising transparency, usability, and usefulness to their primary users. At the same time, they need to demonstrate improved efficiency and diagnostic accuracy. In addition, they also need to provide effective communication of relevant information. This paper describes the use of design science to develop and evaluate a DSS incorporated into online tools to support sleep physician’s diagnosis of sleep disorders. The design science approach offers guidance for developing this solution, that ensure the artefacts fit into their usage context, and that development and evaluation principles that generalise to similar problem domains are identified. How this project fits in the design science guidelines is specified, thus demonstrating how this philosophy and methodology advances theory particularly relevant to other similar medical diagnostic domains. The usability and technical evaluation of the set of tools indicated provide clear practical benefits at patient, physician and organisational levels.
The study of extraneous conditions that affect tilt-based pointer movements
Authors: Serackis Artūras , Miniotas Darius , Katkevičius Andrius , Krukonis Audrius , Plonis Darius 
Published: November 2016

Introduction: With the rapid evolution of mobile devices, there is also a tremendous
growth in their applications. This triggers new research on more efficient techniques of humancomputer
interaction. To point at an object of interest seen on the screen of a mobile device,
various new methods were suggested recently.
Methods: This paper presents the results of a user study that employed tilting as a technique for
entering text. The independent variables in the user study were mobility (sitting, walking, sitting
in the moving bus) and keyboard size (5×3, 10×4). The experiment involved 50 participants aged
from 22 to 65.
Results: In the walking condition, it took on average 11.3% more time for participants to complete
the task compared to the sitting condition with 5×3 keyboard, and 45.1% more time compared to
the sitting condition with 10×4 keyboard. Keyboard size had a marked influence on task
completion time. In addition, task completion time while traveling by bus was 3.2% longer than
that observed for the walking condition with 5×3 keyboard. Surprisingly, task completion time
with 10×4 keyboard while traveling by bus was 10.4% shorter compared to the walking condition.
Error rate and movement efficiency were investigated additionally to find out the explanation for
such performance data.
Assessment of Optimized Process Quality and Reliability for Wafer Level Applications
Authors: Ogawa Ennis , Xing Aimin , Liao David F.-S. , Ten Ten V. Y. , Neo Chong Wei , Chiang Feynman W.-C. , See Gaius , Chaara Mabrouk , Hung George , Jahja Endruw , Nguyen Steven , Hsieh Michael , Chen Ricky W. M. , Ho Darren M.-L. , Mulford Susan R. , Jorge-Estevez Hugh , Lau Melissa , Hilborn Leah , Shah Kashish , Mah Richard , Mendoza Jeff , Zhu Bei , Kirkpatrick Galen , Hsieh Ying-Ying , Samson Paolo , Tong James S. J. , Tsau Liming , Wang J.K. , Reddy Vijay , Hui Frank , Sandhu Javed , Nair Manoj , Tan Keith , Law Edward 
Published: November 2016

Fanout Wafer Level Packaging (FoWLP) is a very attractive solution for microelectronics applications requiring optimized performance, smaller form factor, and low cost. By utilizing such an approach where system integration is done to multiple chips on a single package frame, the need to ensure much higher levels of process integrity, quality, and reliability becomes absolutely critical, especially if the total product volume lies in the range of tens of millions of units. A single defect type may negate the benefits of such an approach because the cost of losing one FoWLP unit results in the loss of multiple devices. Thus, yield, quality, and reliability optimization using such a package solution is critical for successful large scale manufacturing.
In this talk, the issue of defectivity and its impact on quality and reliability on Wafer-Level (WL) devices with regards to the issue of Die Edge Delamination (DED) and Chip Mechanical Integrity (CMI) is discussed. Through this discussion and the resulting solutions found to improve WL quality and reliability, better understanding on how to assess the quality and reliability of a given FoWLP solution for large scale production will be demonstrated.
Role of endoscopic ultrasound in pediatric gastrointestinal diseases
Authors: Singh Rajiv Ranjan , Choudhary Narendra Singh , Puri Rajesh 
Published: November 2016

AbstractEndoscopic ultrasound (EUS) is a well-established diagnostic and therapeutic modality for adults. It is extremely helpful for a broad range of diagnostic indications including upper gastrointestinal (GI) malignancies, submucosal lesions, pancreatic lesions (masses, cystic lesions), chronic pancreatitis, etiological workup of recurrent acute pancreatitis, common bile duct evaluation (calculi versus tumor), gallbladder lesions/microliths, and rectal malignancy; well-established therapeutic roles include fine-needle aspiration of lesions/lymph nodes, pancreatic fluid collection drainage, pancreatic duct drainage, biliary drainage, gallbladder drainage, pelvic abscess drainage, celiac plexus block, or neurolysis. Some recent studies have reported the use of EUS in the pediatric population. EUS is safe and easy to perform in the pediatric population also. However, there is paucity of data on use of EUS in pediatric population. In contrast with its regular therapeutic use in adults, EUS is not commonly performed in children for therapeutic reasons and most of the data are available on diagnostic use only. All of studies have shown that EUS is safe and a useful modality with a positive impact on management in majority of study population. EUS is very useful in pediatric population for the evaluation of upper GI tract submucosal lesions or rectal masses, pancreaticobiliary disorders, characterization of esophageal strictures, and for evaluation of enteric duplication cysts. The advent of miniprobe that can be passed through conventional endoscopes has increased the applicability of EUS in infants and children. Although there are limited data regarding use of EUS in pediatric population, it appears to be a very promising diagnostic and therapeutic tool.
Pulmonary Hypertension in Heart Failure Patients Presenting at OAUTHC, Ile-Ife, Nigeria
Authors: Amadi Valentine N. , Ajayi Olufemi E. , Akintomide Anthony O. , Abiodun Olugbenga O. , Bamikole Olaniyi J. , Balogun Michael O. 
Published: November 2016

BackgroundPulmonary hypertension (PH) is common in heart failure patients. Literature on PH in heart failure is sparse in Nigeria. This study was carried out to determine the prevalence of PH in heart failure patients and ascertain the relationship between left ventricular systolic and diastolic function and the degree of PH.MethodsA total of 125 heart failure patients had echocardiography done. PH was diagnosed using tricuspid regurgitation jet and pulmonary ejection jet profile.ResultsPH was present in 70.4% of heart failure patients. Estimated mean pulmonary arterial pressure increased with increasing severity of systolic and diastolic dysfunction and had significantly negative correlation with ejection fraction, fractional shortening, and early mitral annular tissue diastolic velocity ( E′), but positive correlation with left ventricular end-systolic volume, right ventricular dimension, transmitral E to A ratio, and E/E′ ratio.ConclusionPH is very common in heart failure and has significant relationship with left ventricular function.
Information and Communication Technology and Contesting Gender Hierarchies: Research Learnings from Africa and the Middle East
Authors: Webb Anne 
Published: November 2016

Abstract
Communication policies intended to contribute to changing persistent inequalities need to be informed by an in-depth understanding of systemic barriers to gender equality and women's empowerment. Not taking into account complex, historically entrenched forces that perpetuate established gendered hierarchies may result in policies effecting only superficial change. The research presented in this article demonstrates how availability of information and communication technology (ICT) does not ensure equitable access and gender equality. Access needs to be imbedded in a women's empowerment and equality agenda to contribute to transforming gender relations. Understanding what that involves is critical to the design of ICT policies that challenge gender inequalities.
Qualitative and quantitative analysis of major constituents from Dazhu Hongjingtian capsule by UPLC/Q‐TOF‐MS/MS combined with UPLC/QQQ‐MS/MS
Authors: Liu Guang‐Da , Zhao Yi‐Wu , Li Yan‐Jing , Wang Xue‐Jing , Si Hai‐Hong , Huang Wen‐Zhe , Wang Zhen‐Zhong , Ma Shi‐Ping , Xiao Wei 
Published: November 2016

AbstractIn this work, a sensitive and efficient method was established and validated for qualitative and quantitative analysis of major bioactive constituents in Dazhu Hongjingtian capsule by liquid chromatography tandem mass spectrometry. A total of 32 compounds were tentatively identified using ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry. Furthermore, 12 constituents, namely gallic acid, 3,4‐dihydroxybenzoic acid, salidroside, p‐coumaric acid‐4‐O‐β‐d‐glucopyranoside, bergeninum, 4‐hydroxybenzoic acid, 4‐hydroxyphenylacetic acid, syringate, 6′′‐O‐galloylsalidroside, rhodiosin, rhodionin and kaempferol‐7‐O‐α‐l‐rhamnoside, were simultaneously quantified by the developed ultra‐performance liquid chromatography coupled with a triple quadrupole mass spectrometry method in 9 min. All of them were analyzed on an Agilent ZorBax SB‐C18 column (3.0 × 100 mm, 1.8 μm) with linear gradient elution of methanol–0.1% formic acid water. The proposed method was applied to analyze three batches of samples with acceptable linearity (R, 0.9979–0.9997), precision (RSD, 1.3–4.7%), repeatability (RSD, 1.7–4.9%), stability (RSD, 2.2–4.9%) and recovery (RSD, 0.6–4.4%) of the 12 compounds. As a result, the analytical method possessing high throughput and sensitivity is suitable for the quality control of Dazhu Hongjingtian capsule.
Effects of preoperative statin use on perioperative outcomes of carotid endarterectomy
Authors: Ballotta Enzo , Toniato Antonio , Farina Filippo , Baracchini Claudio 
Published: November 2016

AbstractObjectivesSeveral studies have shown the beneficial role of statins in reducing the risk of major perioperative complications and death associated with noncardiac vascular surgery, but few have focused on their effects in the event of carotid endarterectomy (CEA). This study analyzes the effects of preoperative statin use on perioperative outcomes in patients undergoing CEA.Materials and MethodsData from all consecutive patients who underwent primary CEA for symptomatic and asymptomatic carotid disease between 2002 and 2014 at a single institution were prospectively stored in a vascular surgery registry, recording risk factors, medication, and indication for surgery. Endpoints of the study were perioperative (30‐day) stroke and death.ResultsOverall, 784 patients were on statins (825 CEAs, Group I), while 494 were not (545 CEAs, Group II). There were two perioperative strokes in Group I (0.24%) and four in Group II (0.73%; p = .22), and no deaths. The only nonfatal cardiac complication occurred in Group II (0.18%, p = .39). A neurologist assessed patients at 1, 6, and 12 months after CEA, and every 2 years thereafter. Follow‐up (range: 0.1–13 years; mean, 6.3 ± 3.7 years) was obtained for 1,239 patients (1,326 CEAs). Because 165 patients (166 CEAs) crossed over from Group II to Group I during the follow‐up time, long‐term data were stratified by postoperative statin treatment rather than by preoperative statin use. The 5‐ and 10‐year restenosis/occlusion and survival rates did not differ significantly between the two groups.ConclusionsTaking statins prior to CEA did not seem to affect the risk of major perioperative ischemic events and death, most likely due to the extremely low overall incidence of perioperative complications.
Extensive intracranial arterial stenoses in conjunction with the use of tyrosine kinase inhibitor Nilotinib
Authors: Alshiekh‐Nasany Ruham , Zidan Awss , Martinez Carmen 
Published: November 2016

Key Clinical MessageNew‐generation tyrosine kinase inhibitors (TKI) are promising agents for the treatment of chronic myeloid leukemia (CML), but the linkage to vascular diseases warrants a special attention from treating physicians, as it may carry major morbidity and mortality.
Spatial patterns of an endemic Mediterranean palm recolonizing old fields
Authors: Jácome‐Flores Miguel E. , Delibes Miguel , Wiegand Thorsten , Fedriani José M. 
Published: November 2016

AbstractThroughout Europe, increased levels of land abandonment lead to (re)colonization of old lands by forests and shrublands. Very little is known about the spatial pattern of plants recolonizing such old fields. We mapped in two 21–22‐ha plots, located in the Doñana National Park (Spain), all adult individuals of the endozoochorous dwarf palm Chamaerops humilis L. and determined their sex and sizes. We used techniques of spatial point pattern analysis (SPPA) to precisely quantify the spatial structure of these C. humilis populations. The objective was to identify potential processes generating the patterns and their likely consequences on palm reproductive success. We used (1) Thomas point process models to describe the clustering of the populations, (2) random labeling to test the sexual spatial segregation, and (3) mark correlation functions to assess spatial structure in plant sizes. Plants in both plots showed two critical scales of clustering, with small clusters of a radius of 2.8–4 m nested within large clusters with 38–44 m radius. Additional to the clustered individuals, 11% and 27% of all C. humilis individuals belonged to a random pattern that was independently superimposed to the clustered pattern. The complex spatial pattern of C. humilis could be explained by the effect of different seed‐dispersers and predators' behavior and their relative abundances. Plant sexes had no spatial segregation. Plant sizes showed a spatial aggregation inside the clusters, with a decreasing correlation with distance. Clustering of C. humilis is strongly reliant on its seed dispersers and stressful environmental conditions. However, it seems that the spatial patterns and dispersal strategies of the dwarf palm make it a successful plant for new habitat colonization. Our results provide new information on the colonization ability of C. humilis and can help to develop management strategies to recover plant populations.
Effect of genioglossus, geniohyoid, and digastric advancement on tongue base and hyoid position
Authors: Kutzner Emily A. , Miot Christelle , Liu Yuan , Renk Elizabeth , Park Joshua S. , Inman Jared C. 
Published: November 2016

Objectives/HypothesisTo assess the effect of genioglossus, geniohyoid, and anterior digastric muscle advancement on base of tongue and hyoid position.Study DesignCadaver experiments.MethodsIn fresh cadavers, the mandibular attachments of the genioglossus, geniohyoid, and anterior digastric muscles were advanced anteriorly by 6, 10, or 14 mm, and the anterior displacement of the base of tongue and hyoid was measured. The degrees of displacement of the tongue base and hyoid by the individual muscles and combinations of muscles were compared to one another.ResultsIn 11 cadavers, 462 measurements were taken. Genioglossus advancement alone produced significantly greater tongue base advancement than any other muscle (P < .001). No combination of muscles produced significantly more tongue base advancement than the genioglossus alone. Geniohyoid (P < .001) and anterior digastric muscle (P < .001) advancement both produced significantly greater hyoid advancement than the genioglossus, but there was no difference between the two (p = .615). No combination of muscles produced significantly more hyoid advancement than the geniohyoid or anterior digastric alone.ConclusionsGenioglossus muscle advancement produces the greatest base of tongue advancement. Geniohyoid or anterior digastric muscle advancement produces the greatest hyoid advancement. Advancement of neither base of tongue nor hyoid was superior when combinations of muscles were moved.Level of EvidenceNA Laryngoscope, 127:1938–1942, 2017
Dynamic updating atlas for heart segmentation with a nonlinear field‐based model
Authors: Cai Ken , Yang Rongqian , Yue Hongwei , Li Lihua , Ou Shanxing , Liu Feng 
Published: November 2016

AbstractBackgroundSegmentation of cardiac computed tomography (CT) images is an effective method for assessing the dynamic function of the heart and lungs. In the atlas‐based heart segmentation approach, the quality of segmentation usually relies upon atlas images, and the selection of those reference images is a key step. The optimal goal in this selection process is to have the reference images as close to the target image as possible.MethodsThis study proposes an atlas dynamic update algorithm using a scheme of nonlinear deformation field. The proposed method is based on the features among double‐source CT (DSCT) slices. The extraction of these features will form a base to construct an average model and the created reference atlas image is updated during the registration process. A nonlinear field‐based model was used to effectively implement a 4D cardiac segmentation.ResultsThe proposed segmentation framework was validated with 14 4D cardiac CT sequences. The algorithm achieved an acceptable accuracy (1.0–2.8 mm).ConclusionOur proposed method that combines a nonlinear field‐based model and dynamic updating atlas strategies can provide an effective and accurate way for whole heart segmentation. The success of the proposed method largely relies on the effective use of the prior knowledge of the atlas and the similarity explored among the to‐be‐segmented DSCT sequences.
trans Fatty Acids in Colostrum, Mature Milk and Diet of Lactating Adolescents
Authors: de Souza Santos da Costa Roseli , da Silva Santos Flavia , de Barros Mucci Daniela , de Souza Tânia Vignuda , de Carvalho Sardinha Fátima Lucia , Moutinho de Miranda Chaves Célia Regina , das Graças Tavares do Carmo Maria 
Published: November 2016

AbstractThe purpose of this study was to investigate the trans fatty acids (TFA) content and distribution in colostrum, mature milk, and diet of adolescent mothers, after TFA declaration in food labels became mandatory in Brazil. Participants were healthy adolescents (n 54, 15–19 years, 1–90 days postpartum) practicing exclusive breastfeeding. Milk samples were collected 3 days after delivery (colostrum) and in the third month postpartum (mature milk) by hand expression. The fatty acid composition of the milk samples was determined by gas chromatography. TFA intake corresponded to 1.23 % of total energy value. Total 18:2 TFA accounted for less than 0.5 % of the energy intake. The amount of total 18:1 TFA (mean ± SEM) was 1.9 % ± 0.14 in colostrum and 1.5 % ± 0.2 in mature milk. The total content of n‐3 PUFA was inversely correlated with the total content of 18:1 TFA in colostrum. Both in colostrum and in mature milk, vaccenic acid (11t‐18:1) was found to be the most abundant 18:1 trans isomer, followed by elaidic acid (9t‐18:1), whereas rumenic acid (9c,11t‐18:2 CLA) was the predominant 18:2 trans isomer. In conclusion, the levels of TFA of industrial sources found in the mother's diet and breast milk (colostrum and mature milk) showed a decrease in relation to those observed in studies conducted prior to the TFA labeling resolution in Brazil. However, the current low intake levels of n‐3 LCPUFA and DHA content in the milk of lactating adolescents may be insufficient for supporting adequate neurological development of the infants.
LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation
Authors: Yan Ruiqing , Liu Zhihua 
Published: November 2016

AbstractThe innate immune system is critical for clearing infection, and is tightly regulated to avert excessive tissue damage. Nod1/2-Rip2 signaling, which is essential for initiating the innate immune response to bacterial infection and ER stress, is subject to many regulatory mechanisms. In this study, we found that LRRK2, encoded by a gene implicated in Crohn’s disease, leprosy and familial Parkinson’s disease, modulates the strength of Nod1/2-Rip2 signaling by enhancing Rip2 phosphorylation. LRRK2 deficiency markedly reduces cytokine production in macrophages upon Nod2 activation by muramyl dipeptide (MDP), Nod1 activation by D-gamma-Glu-meso-diaminopimelic acid (iE-DAP) or ER stress. Our biochemical study shows that the presence of LRRK2 is necessary for optimal phosphorylation of Rip2 upon Nod2 activation. Therefore, this study reveals that LRRK2 is a new positive regulator of Rip2 and promotes inflammatory cytokine induction through the Nod1/2-Rip2 pathway.