bluuebunny/crossref_metadata_2025_split huggingface dataset:
An estimation of US horse‐owner/caregiver willingness‐to‐pay for daily use and infectious upper respiratory disease treatment options
Authors: Kibler M. L. , Pendell D. L. , Costanigro M. , Traub‐Dargatz J. 
Published: November 2017

SummaryBackgroundEquine injury and disease cause two types of costs for those financially responsible for treating and caring for the infected horse(s); direct costs of treating the horse and indirect cost of lost use of the horse for a period of time to the user of the horse (daily horse use). Indirect costs are more difficult to estimate but pose significant financial implications for equine‐owners/caregivers. Additionally, there exists a gap in existing research regarding the valuation of infectious treatment options in horses.ObjectiveTo estimate the value a US horse‐owner/caregiver places on daily horse use and describe respondents’ willingness‐to‐pay for various attributes of equine treatment options.Study designOnline questionnaire survey.MethodsAn online questionnaire was provided to equine‐owners and caretakers, and owner demographic, horse care and horse use information from respondents were requested. Additionally, respondents were presented with hypothetical disease treatment options with the following attributes: daily dosage, number of days of rest required, route of administration and out‐of‐pocket cost to the owner/caretaker through a choice experiment. Data were analysed using a rank‐ordered logit analysis and willingness‐to‐pay estimates for daily use and treatment options were calculated.ResultsResults suggest that the average horse‐owner with an uninsured and insured horse is willing to pay $12.07 (95% confidence interval: −$15.01, −$9.69) and $17.95 (95% confidence interval: −$25.30, −$11.20) per day to reduce lost use days required (due to need for rest) respectively. Respondents showed preferences for oral administration over treatments requiring i.m. injections.Main limitationsAs this study employed an online survey it was subjected to self‐selection bias and a sample size calculation was not performed.ConclusionsVeterinarians and pharmaceutical companies may use these results when promoting various treatment options to horse‐owners/caregivers and in product development. Additionally, promotion efforts may be targeted towards equine‐owners with higher daily use values (owners with insured horses).
Patterns, biases and prospects in the distribution and diversity of Neotropical snakes
Authors: Guedes Thaís B. , Sawaya Ricardo J. , Zizka Alexander , Laffan Shawn , Faurby Søren , Pyron R. Alexander , Bérnils Renato S. , Jansen Martin , Passos Paulo , Prudente Ana L. C. , Cisneros‐Heredia Diego F. , Braz Henrique B. , Nogueira Cristiano de C. , Antonelli Alexandre 
Published: November 2017

AbstractMotivationWe generated a novel database of Neotropical snakes (one of the world's richest herpetofauna) combining the most comprehensive, manually compiled distribution dataset with publicly available data. We assess, for the first time, the diversity patterns for all Neotropical snakes as well as sampling density and sampling biases.Main types of variables containedWe compiled three databases of species occurrences: a dataset downloaded from the Global Biodiversity Information Facility (GBIF), a verified dataset built through taxonomic work and specialized literature, and a combined dataset comprising a cleaned version of the GBIF dataset merged with the verified dataset.Spatial location and grainNeotropics, Behrmann projection equivalent to 1° × 1°.Time periodSpecimens housed in museums during the last 150 years.Major taxa studiedSquamata: Serpentes.Software formatGeographical information system (GIS).ResultsThe combined dataset provides the most comprehensive distribution database for Neotropical snakes to date. It contains 147,515 records for 886 species across 12 families, representing 74% of all species of snakes, spanning 27 countries in the Americas. Species richness and phylogenetic diversity show overall similar patterns. Amazonia is the least sampled Neotropical region, whereas most well‐sampled sites are located near large universities and scientific collections. We provide a list and updated maps of geographical distribution of all snake species surveyed.Main conclusionsThe biodiversity metrics of Neotropical snakes reflect patterns previously documented for other vertebrates, suggesting that similar factors may determine the diversity of both ectothermic and endothermic animals. We suggest conservation strategies for high‐diversity areas and sampling efforts be directed towards Amazonia and poorly known species.
Functional orange juice enriched with encapsulated polyphenolic extract of lime waste and hesperidin
Authors: Afkhami Rana , Goli Mohammad , Keramat Javad 
Published: November 2017

SummaryPolyphenolic extract from lime waste and hesperidin were encapsulated to reduce the bitter taste of flavonoid glycosides, mitigate destruction of nutrients during heat process and increase the nutrition value of orange juice. The properties of polyphenolic extract of lime waste, encapsules, the physicochemical and the sensory factors of enriched orange juice during storage were measured. The value of yield of the process (Y) and encapsulation efficiency (EE) was obtained within the range of 85–90% and 59–71%, respectively. The particle size of samples was reported within the range of 27–41 μm. The physicochemical properties in treatments follow the same pattern when compared with the control sample in 60‐day storage. In the sensory assessment, encapsulated formulas were considered to have the best treatment. If the hesperidin was not encapsulated, 80% of it would have been destroyed during pasteurisation, while when encapsulated, only 18.8–33.18% of hesperidin was destroyed.
Effect of high hydrostatic pressure to sweet potato flour on dough properties and characteristics of sweet potato‐wheat bread
Authors: Carballo Pérez Isela , Mu Tai‐Hua , Zhang Miao , Ji Lei‐Lei 
Published: November 2017

SummaryThe effect of high hydrostatic pressure (HHP, 100–400 MPa) for 20 min at 25 °C to sweet potato flour (SPF) on dough properties and characteristics of sweet potato‐wheat bread was investigated. The particle size of SPF after HHP was decreased significantly. The obvious rupture was observed in granules of SPF after HHP at 300 and 400 MPa by scanning electron microscopy (SEM). After HHP, significant differences on endothermic peak temperatures (TP) of SPF were observed by differential scanning calorimetric (DSC), of which the enthalpy change (ΔH) had a slight increase, expect that at 200 MPa. Gas retention of dough with SPF after HHP increased markedly from 1199 (0.1 MPa) to 1246 ml (100 MPa). Specific loaf volume of bread with SPF at 400 MPa was increased significantly, while the hardness and chewiness were reduced. Thus, SPF treated with HHP at 400 MPa could be potentially used in wheat bread production.
Effects of a family‐support programme for pregnant women with foetal abnormalities requiring pregnancy termination: A randomized controlled trial in China
Authors: Sun Shiwen , Li Junqin , Ma Yuanying , Bu Huilian , Luo Qiong , Yu Xiaoyan 
Published: November 2017

AbstractAimWe examined the effects of a family‐support programme for pregnant women with foetal abnormalities in terms of family support, depression, and post‐traumatic stress symptoms.MethodA randomized controlled trial was conducted from November 2016 to June 2017. A total of 124 pregnant women with foetal abnormalities were recruited and randomly assigned to the intervention group that received a family‐support programme or control group that received only routine care. Self‐reported questionnaires including the Family Adaptation Partnership Growth Affection and Resolve Index, the Edinburgh Postnatal Depression Scale, and the Impact of Event Scale‐Revised were administered before and after intervention.ResultsRelative to the control group, posttest Family Adaptation Partnership Growth Affection and Resolve Index scores and scores on the intimacy domain were significantly higher in the intervention group, the Edinburgh Postnatal Depression Scale and Impact of Event Scale‐Revised scores and the scores on all subscales except the intrusion subscale were significantly lower in the intervention group.ConclusionThe findings of this study suggest that family‐support programme represents an effective and feasible support approach of improving family support and reducing depression and post‐traumatic stress symptoms for pregnant women with foetal abnormalities requiring pregnancy termination.
Mentor judgements and decision‐making in the assessment of student nurse competence in practice: A mixed‐methods study
Authors: Burden Sarah , Topping Anne Elizabeth , O'Halloran Catherine 
Published: November 2017

AbstractAimTo investigate how mentors form judgements and reach summative assessment decisions regarding student competence in practice.BackgroundCompetence assessment is a significant component of pre‐registration nursing programmes in the United Kingdom. Concerns exist that assessments are subjective, lack consistency and that mentors fail to judge student performance as unsatisfactory.DesignA two‐stage sequential embedded mixed‐methods design. Data collected 2012–2013.MethodsThis study involved a whole student cohort completing aUKundergraduate adult nursing programme (N = 41). Stage 1: quantitative data on mentor conduct of assessment interviews and the final decision recorded (N = 330 from 270 mentors) were extracted from student Practice Assessment Documents (PADs). Stage 2: mentor feedback in studentPADs was used in Stimulated Recall interviews with a purposive sample of final placement mentors (N = 17). These were thematically analysed. Findings were integrated to develop a theoretically driven model of mentor decision‐making.ResultsCourse assessment strategies and documentation had limited effect in framing mentor judgements and decisions. Rather, mentors amassed impressions, moderated by expectations of an “idealized student” by practice area and programme stage that influenced their management and outcome of the assessment process. These impressions were accumulated and combined into judgements that informed the final decision. This process can best be understood and conceptualized through the Brunswik's lens model of social judgement.ConclusionMentor decisions were reasoned and there was a shared understanding of judgement criteria and their importance. This impression‐based nature of mentor decision‐making questions the reliability and validity of competency‐based assessments used in nursing pre‐registration programmes.
The impact of social deprivation on the response to a randomised controlled trial of a weight management intervention (BeWEL) for people at increased risk of colorectal cancer
Authors: Fisher A. , Craigie A. M. , Macleod M. , Steele R. J. C. , Anderson A. S. 
Published: November 2017

AbstractBackgroundAlthough 45% of colorectal cancer (CRC) cases may be avoidable through appropriate lifestyle and weight management, health promotion interventions run the risk of widening health inequalities. The BeWEL randomised controlled trial assessed the impact of a diet and activity programme in overweight adults who were diagnosed with a colorectal adenoma, demonstrating a significantly greater weight loss at 12 months in intervention participants than in controls. The present study aimed to compare BeWEL intervention outcomes by participant deprivation status.MethodsThe intervention group of the BeWEL trial (n = 163) was classified by the Scottish Index of Multiple Deprivation (SIMD) quintiles into ‘more deprived’ (SIMD 1–2, n = 58) and ‘less deprived’ (SIMD 3–5, n = 105). Socio‐economic and lifestyle variables were compared at baseline to identify potential challenges to intervention adherence in the more deprived. Between group differences at 12 months in primary outcome (change in body weight) and secondary outcomes (cardiovascular risk factors, diet, physical activity, knowledge of CRC risk and psychosocial variables) were assessed by deprivation status.ResultsAt baseline, education (P = 0.001), income (P < 0.001), spending on physical activity (P = 0.003) and success at previous weight loss attempts (P = 0.007) were significantly lower in the most deprived. At 12 months, no between group differences by deprivation status were detected for changes in primary and main secondary outcomes.ConclusionsDespite potential barriers faced by the more deprived participants, primary and most secondary outcomes were comparable between groups, indicating that this intervention is unlikely to worsen health inequalities and is equally effective across socio‐economic groups.
Cross‐lagged relations between perceived leader–employee value congruence and leader identification
Authors: Marstand Anders F. , Epitropaki Olga , Martin Robin 
Published: November 2017

Building on similarity‐attraction theory and extending research on person–organization value congruence and organizational identification, this study examines the relationship between perceived leader–employee value congruence and leader identification. Using a two‐wave design, data were collected twice with a 6 months’ time lag from a sample of 282 employees. Utilizing cross‐lagged analyses, we examined bidirectional effects between perceived leader–employee value congruence and leader identification. The results provided support for the positive relationship of perceived leader–employee value congruence (Time 1) to leader identification (Time 2) but could not exclude the possibility of a bidirectional relationship. Overall, the study highlights the importance of value congruence for identification processes.Practitioner points

HR professionals should put emphasis on values when matching leaders and employees as the employees’ overall assessment of value fit between the leader's and the employees’ values plays an important role in the employees’ identification with the leader.

As more support was found for perceived leader–employee value congruence affecting leader identification than vice versa, there should be a greater focus on the employee's overall assessment of value fit with the leader than whether the employee identifies with the leader.
Well‐being of nursing staff on specialized units for older patients with combined care needs
Authors: Collet J. , de Vugt M. E. , Schols J. M. G. A. , Engelen G. J. J. A. , Winkens B. , Verhey F. R. J. 
Published: November 2017

Accessible summaryWhat is already known about the subject

Working in long‐term care is seen as a stressful, physically and mentally demanding occupation, and thus, nursing staff are at risk for work and stress‐related diseases.

In older patients, psychiatric illnesses often occur in combination with physical illnesses, requiring nursing care that is specific to these combined care needs. The impact of caring for these patients on the mental well‐being of nurses is unknown.

What this paper adds to existing knowledge

Nursing staff working on specialized units for patients with combined care needs experience high levels of self‐efficacy in combination with strong feelings of self‐rated competence.

Although levels of burnout are relatively low, mental healthcare nursing staff is more at risk for burnout when working in specialized settings for patients with combined care needs than nursing home staff working in specialized settings for these patients.

Nursing staff characteristics, such as years of working experience and age, seem more important in relation to staff well‐being than patient characteristics in specialized settings for combined care needs.

What are the implications for practice

Staff well‐being might benefit from specializing care, so that patients with similar care needs are placed together and care is focused.

The presence of specialized care units for older patients with combined care needs can allow for both targeted and focused allocation of nursing staff to these units and provision of specific training.

AbstractIntroductionIn older patients, psychiatric illnesses frequently exist in tandem with physical illnesses, requiring nursing care that is specific to these combined care needs. The impact of caring for these patients on the mental well‐being of nursing staff is unknown.AimTo investigate whether care characteristics of patients with combined care needs are related to the mental well‐being of nursing staff.MethodWell‐being of nursing staff was studied within a larger exploratory observational cross‐sectional study that examined the differences and similarities of specialized combined care units in Dutch mental healthcare and nursing home settings.ResultsNursing staff across settings, with more than 5 years of work experience, felt competent in caring for patients with combined care needs. No significant effects of care characteristics of patients with combined care needs on the work‐related well‐being of nursing staff were shown. Both mental health nursing staff and older employees, however, were found to be more at risk for burnout.Implications/ConclusionStaff well‐being might benefit from placing patients with combined care needs together, so care is focused. The presence of specialized care units can allow for both targeted and focused allocation of nursing staff to these units and provision of specific training.
Regional Citrate Anticoagulation for Intermittent Hemodialysis in Dogs
Authors: Francey T. , Schweighauser A. 
Published: November 2017

BackgroundThe traditional systemic heparinization used for anticoagulation in extracorporeal therapies may cause fatal complications in animals at risk of bleeding.Hypothesis/ObjectivesTo develop and validate a protocol of regional citrate anticoagulation (RCA) for intermittent hemodialysis in dogs.AnimalsA total of 172 dogs treated with hemodialysis for acute kidney injury.MethodsIn vitro titration was performed, adding trisodium citrate and calcium chloride to heparinized canine blood. A tentative protocol was used first in 66 treatments with additional heparinization and subsequently in 518 heparin‐free treatments. Safety and adequacy of RCA were assessed based on clinical and laboratory monitoring, dialyzer pressure gradient, treatment completion, and visual scoring of the extracorporeal circuit.ResultsAddition of 1 mmol/L citrate to heparinized blood decreased the ionized calcium concentration by 0.23 mmol/L (95% confidence interval [CI], 0.16–0.30) and 1 mmol/L calcium increased it by 0.62 mmol/L (95% CI, 0.45–0.79). Heparin‐free treatments were initiated with infusion of trisodium citrate (102 mmol/L) at 2.55 mmol/L blood and calcium chloride (340 mmol/L) at 0.85 mmol/L. Citrate and calcium administrations were adjusted in 27 and 34% of the treatments, respectively. Overall, anticoagulation was satisfactory in 92% of the treatments, with expected azotemia reduction in 95% (urea) and 86% (creatinine), stable dialyzer pressure gradient in 82%, and clean extracorporeal circuits in 92% of the treatments. Eighteen treatments (3.5%) were discontinued prematurely, 9 because of clotting and 9 for reasons unrelated to the RCA procedure.Conclusions and Clinical ImportanceRegional citrate anticoagulation allows safe and efficient heparin‐free hemodialysis in dogs at risk of bleeding.
Contrast‐Enhanced Ultrasound Examination for the Assessment of Renal Perfusion in Cats with Chronic Kidney Disease
Authors: Stock E. , Paepe D. , Daminet S. , Vandermeulen E. , Duchateau L. , Saunders J.H. , Vanderperren K. 
Published: November 2017

BackgroundContrast‐enhanced ultrasound examination (CEUS) is a functional imaging technique allowing noninvasive assessment of tissue perfusion. Studies in humans show that the technique holds great potential to be used in the diagnosis of chronic kidney disease (CKD). However, data in veterinary medicine are currently lacking.ObjectivesTo evaluate renal perfusion usingCEUSin cats withCKD.AnimalsFourteen client‐owned cats withCKDand 43 healthy control cats.MethodsProspective case‐controlled clinical trial usingCEUSto evaluate renal perfusion in cats withCKDcompared to healthy control cats. Time‐intensity curves were created, and perfusion parameters were calculated using off‐line software. A linear mixed model was used to examine differences between perfusion parameters of cats withCKDand healthy cats.ResultsIn cats withCKD, longer time to peak and shorter mean transit times were observed for the renal cortex. In contrast, a shorter time to peak and rise time were seen for the renal medulla. The findings for the renal cortex indicate decreased blood velocity and shorter total duration of enhancement, likely caused by increased vascular resistance inCKD. Increased blood velocity in the renal medulla has not been described before and may be because of a different response to regulatory factors in cortex and medulla.Conclusions and Clinical ImportanceContrast‐enhanced ultrasound examination was capable of detecting perfusion changes in cats withCKD. Further research is warranted to assess the diagnostic capabilities ofCEUSin early stage of the disease process.
BRAF internal deletions and resistance to BRAF/MEK inhibitor therapy
Authors: Johnson Douglas B. , Childress Merrida A. , Chalmers Zachary R. , Frampton Garrett M. , Ali Siraj M. , Rubinstein Samuel M. , Fabrizio David , Ross Jeffrey S. , Balasubramanian Sohail , Miller Vincent A. , Stephens Philip J. , Sosman Jeffrey A. , Lovly Christine M. 
Published: November 2017

SummaryBRAF and MEK inhibitors have improved clinical outcomes in advanced, BRAFV600‐mutated melanomas. Acquired resistance occurs in most patients, with numerous and diverse drivers. We obtained pretreatment and progression biopsies from a patient who progressed on dabrafenib and trametinib. In addition to a preserved BRAFV600E mutation, an internal deletion (rearrangement) of BRAF was observed in the progression sample. This deletion involved exons 2–8, which includes the Ras‐binding domain, and is analogous to previously documented BRAF fusions and splice variants known to reactivate RAS‐RAF‐MEK‐ERK signaling. In a large cohort of melanomas, 10 additional internal deletions were identified (0.4% of all melanomas; nine of which had concurrent BRAF mutations), as well as sporadically in other tumor types. Thus, we describe a novel mechanism of resistance to BRAF and MEK inhibition.
Visibility and meanings of partnership in health care for older people who need support to live at home
Authors: Gregory Anna , Mackintosh Shylie , Kumar Saravana , Grech Carol 
Published: November 2017

IntroductionProblems experienced by older people with complex needs to live at home have been reported in the literature. This qualitative study builds on previous research and investigates enduring issues older people face when interacting with healthcare services.AimTo gain an in‐depth understanding of what is involved in providing good quality health care for older people who need support to live at home.Methodological designWe adopted an interpretive descriptive approach and conducted semi‐structured interviews with older people (n = 7), carers (n = 8) and key informants (n = 11). Initial and secondary analysis of qualitative data was completed.FindingsMajor themes emerged about meanings of partnership in health care, and invisibility of the older person as a partner in health care. Partnership in health care was understood to mean being treated as an equal, being involved in decision‐making, and making contributions which impact on health care and health systems. The metaphorical concept of ‘invisibility’ related to the older person not being seen and heard as a partner in health care, as well as being a recipient of care.ConclusionsWe concluded that older people who need support to live at home are not highly visible to health providers, policymakers and researchers as a central partner and consumer to be meaningfully engaged in shaping their health care. Opportunities to address persistent issues with quality of health care may in future be achieved through stronger partnerships between older people and health providers, to find new ways to improve the quality of care for older people.