bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mode of delivery and child and adolescent psychological well-being: Evidence from Hong Kong’s “Children of 1997” birth cohort
Authors: Leung Cherry Y. , Leung Gabriel M. , Schooling C. Mary 
Published: November 2017

AbstractMode of delivery (vaginal or cesarean section) is thought to affect gut microbiota, which in turn may affect psychological well-being. As such, mode of delivery is potentially a modifiable factor for psychological well-being. Here we examined the association of mode of delivery with child and adolescent psychological well-being. We used multivariable linear regression in a population-representative Hong Kong Chinese birth cohort, “Children of 1997,” to examine the adjusted associations of mode of delivery with behavioral problems assessed from parent-reported Rutter score at ~7 (n = 6294) and ~11 years (n = 5598), self-esteem assessed from self-reported Culture-Free Self-Esteem Inventory score at ~11 years (n = 6937) and depressive symptoms assessed from self-reported Patient Health Questionnaire-9 score at ~13 years (n = 5797). Cesarean Section (CS) was associated with children born in private hospitals, boys, and firstborns, higher maternal body mass index, higher maternal age, preeclampsia, higher socioeconomic position (SEP) and maternal birth in Hong Kong. CS was unrelated to behavior, self-esteem and depressive symptoms adjusted for infant characteristics (sex, gestational age, birthweight, parity and breast feeding), maternal characteristics (mother’s age and place of birth) and SEP. In a developed non-Western setting, mode of delivery was not clearly associated with childhood or early adolescent psychological well-being.
Comprehensive genomic analysis of a plant growth-promoting rhizobacterium Pantoea agglomerans strain P5
Authors: Shariati J. Vahid , Malboobi Mohammad Ali , Tabrizi Zeinab , Tavakol Elahe , Owlia Parviz , Safari Maryam 
Published: November 2017

AbstractIn this study, we provide a comparative genomic analysis of Pantoea agglomerans strain P5 and 10 closely related strains based on phylogenetic analyses. A next-generation shotgun strategy was implemented using the Illumina HiSeq 2500 technology followed by core- and pan-genome analysis. The genome of P. agglomerans strain P5 contains an assembly size of 5082485 bp with 55.4% G + C content. P. agglomerans consists of 2981 core and 3159 accessory genes for Coding DNA Sequences (CDSs) based on the pan-genome analysis. Strain P5 can be grouped closely with strains PG734 and 299 R using pan and core genes, respectively. All the predicted and annotated gene sequences were allocated to KEGG pathways. Accordingly, genes involved in plant growth-promoting (PGP) ability, including phosphate solubilization, IAA and siderophore production, acetoin and 2,3-butanediol synthesis and bacterial secretion, were assigned. This study provides an in-depth view of the PGP characteristics of strain P5, highlighting its potential use in agriculture as a biofertilizer.
Sodium channel NaV1.3 is important for enterochromaffin cell excitability and serotonin release
Authors: Strege Peter R. , Knutson Kaitlyn , Eggers Samuel J. , Li Joyce H. , Wang Fan , Linden David , Szurszewski Joseph H. , Milescu Lorin , Leiter Andrew B. , Farrugia Gianrico , Beyder Arthur 
Published: November 2017

AbstractIn the gastrointestinal (GI) epithelium, enterochromaffin (EC) cells are enteroendocrine cells responsible for producing >90% of the body’s serotonin (5-hydroxytryptamine, 5-HT). However, the molecular mechanisms of EC cell function are poorly understood. Here, we found that EC cells in mouse primary cultures fired spontaneous bursts of action potentials. We examined the repertoire of voltage-gated sodium channels (NaV) in fluorescence-sorted mouse EC cells and found that Scn3a was highly expressed. Scn3a-encoded NaV1.3 was specifically and densely expressed at the basal side of both human and mouse EC cells. Using electrophysiology, we found that EC cells expressed robust NaV1.3 currents, as determined by their biophysical and pharmacologic properties. NaV1.3 was not only critical for generating action potentials in EC cells, but it was also important for regulating 5-HT release by these cells. Therefore, EC cells use Scn3a-encoded voltage-gated sodium channel NaV1.3 for electrical excitability and 5-HT release. NaV1.3-dependent electrical excitability and its contribution to 5-HT release is a novel mechanism of EC cell function.
Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats
Authors: Jin Li , Piao Zhe Hao , Sun Simei , Liu Bin , Kim Gwi Ran , Seok Young Mi , Lin Ming Quan , Ryu Yuhee , Choi Sin Young , Kee Hae Jin , Jeong Myung Ho 
Published: November 2017

AbstractGallic acid (GA) has been reported to have beneficial effects on cancer, vascular calcification, and diabetes-induced myocardial dysfunction. We hypothesized that GA controls hypertension via oxidative stress response regulation in an animal model for essential hypertension. Spontaneously hypertensive rats (SHRs) were administered GA for 16 weeks. GA treatment lowered elevated systolic blood pressure in SHRs through the inhibition of vascular contractility and components of the renin-angiotensin II system. In addition, GA administration reduced aortic wall thickness and body weight in SHRs. In SHRs, GA attenuated left ventricular hypertrophy and reduced the expression of cardiac-specific transcription factors. NADPH oxidase 2 (Nox2) and GATA4 mRNA expression was induced in SHR hearts and angiotensin II-treated H9c2 cells; this expression was downregulated by GA treatment. Nox2 promoter activity was increased by the synergistic action of GATA4 and Nkx2-5. GA seems to regulate oxidative stress by inhibiting the DNA binding activity of GATA4 in the rat Nox2 promoter. GA reduced the GATA4-induced Nox activity in SHRs and angiotensin II-treated H9c2 cells. GA administration reduced the elevation of malondialdehyde levels in heart tissue obtained from SHRs. These findings suggest that GA is a potential therapeutic agent for treating cardiac hypertrophy and oxidative stress in SHRs.
Phosphorylation Dynamics Dominate the Regulated Proteome during Early Xenopus Development
Authors: Peuchen Elizabeth H. , Cox Olivia F. , Sun Liangliang , Hebert Alex S. , Coon Joshua J. , Champion Matthew M. , Dovichi Norman J. , Huber Paul W. 
Published: November 2017

AbstractThe earliest stages of animal development are largely controlled by changes in protein phosphorylation mediated by signaling pathways and cyclin-dependent kinases. In order to decipher these complex networks and to discover new aspects of regulation by this post-translational modification, we undertook an analysis of the X. laevis phosphoproteome at seven developmental stages beginning with stage VI oocytes and ending with two-cell embryos. Concurrent measurement of the proteome and phosphoproteome enabled measurement of phosphosite occupancy as a function of developmental stage. We observed little change in protein expression levels during this period. We detected the expected phosphorylation of MAP kinases, translational regulatory proteins, and subunits of APC/C that validate the accuracy of our measurements. We find that more than half the identified proteins possess multiple sites of phosphorylation that are often clustered, where kinases work together in a hierarchical manner to create stretches of phosphorylated residues, which may be a means to amplify signals or stabilize a particular protein conformation. Conversely, other proteins have opposing sites of phosphorylation that seemingly reflect distinct changes in activity during this developmental timeline.
EGFR conjunct FSCN1 as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer
Authors: Wang Chao-Qun , Li Yang , Huang Bi-Fei , Zhao Yong-Ming , Yuan Hui , Guo Dongfang , Su Chen-Ming , Hu Gui-Nv , Wang Qian , Long Tengyun , Wang Yan , Tang Chih-Hsin , Li Xiaoni 
Published: November 2017

AbstractEmerging evidence indicates that Fascin-1 (FSCN1) may possess a causal role in the development of several types of cancers and serves as a novel biomarker of aggressiveness in certain carcinomas. However, the regulatory mechanism of FSCN1 in triple-negative breast cancer (TNBC) cell invasion and migration is still largely unknown. In our study, we observed that the FSCN1 expression rates were significantly higher in invasive ductal carcinoma, compared with both usual ductal hyperplasia and ductal carcinoma in situ. FSCN1 expression was significantly higher in cases of TNBC compared with the non-TNBC subtype. Overexpression of FSCN1 promoted TNBC cell migration and invasion. Epidermal growth factor induced the expression of FSCN1 through activation of MAPK, which subsequently promoted cell migration and invasion. A significant decrease in FSCN1 expression following the co-treatment of FSCN1 siRNA and Gefitinib, compared with the separate treatment of FSCN1 siRNA or Gefitinib. Furthermore, we found that there was a significant association between FSCN1 expression and poor relapse-free survival and overall survival. Therefore, we suggest that co-targeting epidermal growth factor receptor and FSCN1 dual biomarker may be used as a novel therapeutic strategy for TNBC.
The Role of Phonological Working Memory and Environmental Factors in Lexical Development in Italian-Speaking Late Talkers: A One-Year Follow-Up Study
Authors: Marini Andrea , Ruffino Milena , Sali Maria Enrica , Molteni Massimo 
Published: November 2017

Purpose
This follow-up study assessed (a) the influence of phonological working memory (pWM), home literacy environment, and a family history of linguistic impairments in late talkers (LTs); (b) the diagnostic accuracy of a task of nonword repetition (NWR) in identifying LTs; and (c) the persistence of lexical weaknesses after 10 months.

Method
Two hundred ninety-three children were assessed at approximately 32 (t1) and 41 (t2) months. At t1, they were administered the Italian adaptation of the Language Development Survey, an NWR task (used to assess pWM), and questionnaires assessing home literacy environment and family history of language impairments. Thirty-three LTs were identified. The linguistic skills of the participants were evaluated at t2 by administering tasks assessing Articulation, Naming, Semantic Fluency, and Lexical Comprehension.

Results
At t2, LTs performed more poorly as compared with age-matched typically developing peers in articulatory and naming skills, had reduced lexical comprehension abilities, and had limited lexical knowledge. Their performance on the NWR task at t1 correlated with the extension of their vocabularies at t2 (as estimated with a Semantic Fluency task).

Conclusions
The Language Development Survey recently adapted to Italian is sensitive to LTs. Former LTs still have a mild lexical delay at approximately 40 months. As an indirect measure of pWM, the task of NWR is an early indicator of future lexical deficits.
Future Interventional Oncology Catheter-Based Therapies
Authors: Noda Christopher , Roubhaka Mihail , Charalel Resmi , Masrani Abdulrahman , Akinwande Olaguoke 
Published: November 2017

AbstractMinimally invasive techniques in the treatment of cancer continue to develop at a rapid pace. Although surgical resection currently remains the only option for a complete cure, not all diseases are amenable to complete removal. This leaves opportunities to develop effective downstaging techniques as well as palliative care. In the realm of minimally invasive oncologic techniques, catheter-based therapies are an attractive option because malignancies require a blood supply to remain active. The intra-arterial (IA) delivery of specific tumoricidal drugs has been shown to be a successful delivery method in a variety of different cancers, and it is currently a progressive area of research. There is work both to increase the delivery specificity of oncologic drugs, including SW43 sigma receptor ligand and nanoparticle research. In addition, oncolytic viral therapy and 3-bromopyruvate have become increasingly more attractive tumoricidal drug prospects. In the future, the success of these therapies will ultimately determine the degree to which IA delivery will compete with the systemic delivery of drugs in the treatment of cancer.
A Review of the Incidence, Manifestation, Predisposing Factors, and Management of Recurrent Pediatric Inguinal Hernia
Authors: Koivusalo Antti 
Published: November 2017

AbstractRecurrent pediatric inguinal hernia is relatively rare. In a large series, the recurrence rates vary from 0.3 to 1.2%. In a university hospital with surgical service for a wide spectrum of sick pediatric patients, the real recurrence rate may be 3 to 6%. Recurrence manifests typically 6 months after first repair. Current evidence indicates that recurrence rates in open and laparoscopic repair are similar. Laparoscopic repairs are, however, still performed by a minority of skilled pediatric surgeons, whereas the majority of pediatric surgeons rely on open repair not least because of the assumed lower risk of recurrence. After repair of an indirect hernia, the majority of recurrences (97%) are indirect, whereas in rare cases the recurrence turns out to be a formerly undiagnosed direct or femoral hernia. In Children's Hospital of Helsinki, Finland, recurrence rate from 2012 to 2016 was 2.8% and operations for recurrent hernias comprised 3.3% of the total. From 1991 to 2017, a total of 130 operations for recurrent hernias were performed with open inguinal approach (n = 75, 58%), laparoscopy (n = 49, 38%), and laparotomy (n = 4, 4%). One teenage patient underwent a Lichtenstein Prolene net repair. A recurrent inguinal hernia can be repaired either with an open or laparoscopic approach. In laparoscopy, the nature of the recurrent hernia can be clarified and an immediate repair performed either by laparoscopic or open technique. In expert hands new laparoscopic techniques using muscular arch, lateral umbilical ligament, iliopubic tract, and division of the sac may be an alternative to a simple purse-string closure.
Beeinflusst das Strukturniveau den Erfolg tagesklinischer Behandlung? Ergebnisse einer Längsschnittuntersuchung
Authors: Scherg Nina , Karcher Anna , Zimmermann Johannes , Hörz-Sagstetter Susanne 
Published: November 2017

ZusammenfassungIn einer explorativen, fragebogengestützten Untersuchung (n=63) wurde die Bedeutung des Strukturniveaus für den Erfolg tagesklinischer Behandlung untersucht. Die Datenerhebung zu Beginn und Ende der 4-6wöchigen Behandlung umfasste Daten zur aktuellen Symptombelastung (SCL-90-R, BDI-2), zum Strukturniveau (IPO-16), zu Persönlichkeitsstörungen (ADP- IV) sowie zu traumatischen Erfahrungen in Kindheit und Jugend (CTQ). Es wurden starke Zusammenhänge zwischen strukturellen Defiziten, Persönlichkeitspathologie, Traumatisierung und Symptombelastung gefunden. Es ergaben sich keine signifikanten Veränderungen im Strukturniveau im Behandlungszeitraum. Ein Einfluss des Strukturniveaus auf den Behandlungserfolg konnte entgegen den Ergebnissen bisheriger Studien nicht gezeigt werden. Die Bedeutung des Strukturniveaus für die Behandlungsplanung sollte weiter untersucht werden.
Faktorielle Validität und Konstruktvalidität des ICD-10-Symptom-Ratings (ISR) in einer klinisch weitgehend unauffälligen Stichprobe
Authors: Braun Sarah , Zimmermann Julia , Söhner Stephanie , Neidhardt Sylwia 
Published: November 2017

Zusammenfassung
Einleitung Das ICD-10-Symptom-Rating (ISR) ist ein Selbstbeurteilungsinstrument, das sich an der syndromalen Struktur des ICD-10 orientiert. Lassen sich bisherige Befunde zur Validität des Instruments in klinischen Stichproben in einer klinisch weitgehend unauffälligen Stichprobe replizieren?
Material & Methoden N=428 vorrangig studentische Versuchspersonen füllten das ISR und die SCL-90-R online aus.
Ergebnisse Die theoretisch postulierte faktorielle Struktur des ISR konnte mit einer guten Modellanpassung repliziert werden. Die Korrelationen zwischen den konstruktverwandten Skalen der beiden Instrumente reichten von rmin=0,60 bis rmax=0,85. Das Ausfüllen des ISR wurde als wenig belastend eingestuft.
Diskussion und Schlussfolgerung Diese Ergebnisse sind als Hinweise auf die Validität und Zumutbarkeit des ISR zu werten.
Concurrent Training with Blood Flow Restriction does not Decrease Inflammatory Markers
Authors: de Souza Thiago , Libardi Cleiton , Cavaglieri Cláudia , Gáspari Arthur , Brunelli Diego , de Souza Giovana , Ugrinowitsch Carlos , Min Li Li , Chacon-Mikahil Mara 
Published: November 2017

AbstractThe aging process is associated with several changes in the elderly such as the decrease in cardiorespiratory fitness, strength and muscle mass, in addition to chronic low-grade inflammation. Concurrent training with blood flow restriction can be an interesting alternative to improve functional capacity with low mechanical stress in the elderly. The purpose of this study was to compare the inflammatory effects in older individuals submitted to two different protocols of concurrent training. Twenty-two healthy older adults (63.7±3.8 years; 69.8±8.9 kg; 1.6±0.1 m) performed 12 weeks of concurrent training (CT) or concurrent training with blood flow restriction (CTBFR) and the effects on inflammatory markers were analyzed. We found inflammatory behavior for the CTBFR group with a significant difference in serum concentration of C-reactive protein between pre- and post-moment (0.96±0.37 to 1.71±1.45, p=0.049), with no difference between groups, and a time effect in interleukin-6 (pre=0.86±0.43; post=1.02±0.46, p=0.016). We conclude that the CTBFR showed a pro-inflammatory profile after the period of intervention whereas the CT showed the opposite.
Aus-, Fort- und Weiterbildung in Public Health – wo stehen wir heute?
Authors: Dierks Marie 
Published: November 2017

ZusammenfassungDie Aus-, Fort- und Weiterbildung in Public Health findet in Deutschland auf der Ebene von Universitäten, Hochschulen für Angewandte Wissenschaften und Akademien und statt, in unterschiedlicher Intensität und mit z. T. unterschiedlichen Bezeichnungen. Der Artikel gibt einen Überblick über die historische Herausbildung der aktuellen Strukturen, umreißt die Herausforderungen für eine Weiterentwicklung und gruppiert mögliche Angebote unter den 3 von der Weltgesundheitsorganisation vorgeschlagenen zentralen Zielgruppen „Fachkräfte für das Öffentliche Gesundheitswesen“, „Gesundheitsfachkräfte, die sich mit der individuellen Versorgung von Patienten befassen“ und „Zielgruppen, die außerhalb des Gesundheitswesen arbeiten, aber für Entscheidungen verantwortlich sind, die sich auf die Gesundheit der Bevölkerung auswirken“.
Work-based higher education programmes in Germany and the US: Comparing multi-actor corporatist governance in higher education
Authors: Graf Lukas 
Published: November 2017

AbstractIn both Germany and the United States, employers search for new strategies to recruit and train people in times of a dynamically evolving economy and rising educational expectations on the part of individuals. In this context, we observe the proliferation of work-based higher education programmes in both countries. This development challenges the common classification found in the political economy and educational policy literature that distinguishes between collectively governed dual apprenticeships in Germany and market-driven on-the-job training in the US. The paper proposes an alternative conceptualization that identifies significant similarities in the governance mode of work-based higher education across the two countries. Based on expert interviews and document analysis, the institutional analysis focuses on complex multi-actor governance constellations at the nexus of vocational training and higher education and explores consequences for contemporary policy-making in advanced skill formation.
Understanding policy problems: a refinement of past work
Authors: Hoornbeek John A , Peters B Guy 
Published: November 2017

AbstractTo better connect the concept of policy problems to policy solutions, this article builds on Guy Peters’ framework for identifying and applying ‘attributes’ of policy problems. It does so by applying the seven attributes of policy problems identified in Peters’ past work to a range of policy problems in the United States. The problems investigated include access to healthcare, the organization of public health services, and water pollution. By applying Peters’ attributes to these policy problems, we assess the range of the framework’s application to different types of policy problems. We also identify insights that can be used to enable improvements to the framework over time, which may enhance our ability to characterize policy problems in ways that guide policy design.
The absence of institutional entrepreneurship in climate adaptation policy – in search of local adaptation strategies for Rotterdam’s unembanked areas
Authors: Duijn Michael , van Buuren Arwin 
Published: November 2017

Abstract
Innovative policy measures often imply institutional adjustments. Whether such adjustments are accomplished often depends upon the presence of institutional entrepreneurship: actors who take responsibility to initiate the necessary actions to redesign existing institutional practices. The question arises under which conditions can institutional entrepreneurship be developed? And, what might be the cause of lacking institutional entrepreneurship?
In this article, the latter question is examined through in-depth collaborative research project for exploring alternative, adaptive flood risk strategies for flood proofing the unembanked area of the north-end of the city district Feijenoord in Rotterdam. Due to climate change, these areas are increasingly vulnerable to flooding. The traditional, institutionalized solution of raising the ground level before initiating new spatial developments does not suffice in the long term. Therefore, the city government explored alternative strategies for more adaptive ways of dealing with flood risks. Together with representatives of key stakeholders in the area, two key strategies for the unembanked areas were elaborated. These strategies have significant implications for the distribution of costs, risks and responsibilities and necessitate alternative governance architectures that exceed the current institutional structures.
During the research project, it became clear that the developed alternative strategies fundamentally differed from the current institutional system. Thus, institutional redesign was necessary. This proved to be virtually impossible, especially because none of the involved actors was willing nor capable of undertaking entrepreneurial activities to start such redesign. This observation led us to further investigate into the causes and the consequences of the absent entrepreneurship.