bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bonding performance of universal adhesive systems with dual-polymerising resin cements to various dental substrates: In vitro study
Authors: Takano Shunsuke , Takahashi Rena , Tabata Tomoko , Zeng Chen , Ikeda Masaomi , Shimada Yasushi 
Published: October 2024

Abstract

Background
Resin cements often require substrate-specific pretreatment. Recently, universal adhesive systems have been introduced, simplifying procedures by eliminating the need for multiple adhesives and offering options that do not require light curing. This study investigated the bonding performance of universal adhesive systems combined with dual-polymerising resin cements on enamel, dentin, zirconia, lithium disilicate ceramics (LDS), and resin blocks.
Methods
Two universal adhesive and dual-polymerising resin cement combinations from the same manufacturer were tested: Bondmer Lightless II (BLII) with Estecem II (ECII), and Scotchbond Universal Plus adhesive (SBU) with RelyX Universal resin cement (RXU). Enamel, dentin, zirconia (Katana Zirconia UTML), LDS (IPS e.max CAD CEREC), and resin blocks (Katana Avencia P Block) were used as substrates. The universal adhesive was applied to all bonding surfaces, followed by resin cement application in micro-bore Tygon tubes and light curing for 40 s. Micro-shear bond strength (µSBS) was measured after 0 thermal cycles (0TC) or 10,000 thermal cycles (10kTC) (n = 20). Statistical analyses were conducted using t-tests and Welch's t-tests with Bonferroni correction (α = 0.05), and failure modes were examined.
Results
In the BLII/ECII group, the mean µSBS values exceeded 15 MPa for all substrates at 0TC. After thermocycling, µSBS increased significantly for the enamel (p < 0.05), remained unchanged for dentin and zirconia (p > 0.05) and decreased for LDS and resin blocks (p < 0.05). In the SBU/RXU group, 0TC µSBS values exceeded 15 MPa for enamel, zirconia, and resin blocks, but thermocycling significantly decreased µSBS for all substrates (p < 0.05). Comparison between BLII/ECII and SBU/RXU group showed no significant differences for enamel and resin blocks at 0TC (p > 0.05), but the BLII/ECII group exhibited higher SBS than the other groups (p < 0.05). Adhesive failure was the most frequently observed failure type across all groups.
Conclusion
The adhesive performance on diverse dental substrates including enamel, dentin, zirconia, LDS, and resin composites was notably affected by the selection of universal adhesive systems in combination with dual-polymerising resin cements that were applied. The BLII/ECII combination demonstrated long-term stable bonding performance for enamel, dentin, and zirconia.
Mutant Fam20c knock-in mice recapitulate both lethal and non-lethal human Raine Syndrome
Authors: Chen Mengnan , Sun Dongmei , Yee Sui-Pok , Yuan Zhaoyang , Lin Li , Cui Bing , Wang Yi , Liu Chao , Liu Peihong 
Published: October 2024

Abstract

Inactivation or mutations of FAM20C causes human Raine Syndrome, which manifests as lethal osteosclerosis bone dysplasia or non-lethal hypophosphatemia rickets. However, it is only hypophosphatemia rickets that was reported in the mice with Fam20c deletion or mutations. To further investigate the local and global impacts of Fam20c mutation, we constructed a knock-in allele carrying Fam20c mutation (D446N) found in the non-lethal Raine Syndrome. The Fam20cD446N allele replaced the WT Fam20c by 3.6Kb Col1a1-Cre to get the conditional knock-in mice, and by Hprt-cre to get conventional knock-in mice, respectively. The radiology, serum biochemistry and immunohistochemistry indicated that all conditional and most conventional Fam20cD446N knock-in mice displayed hypophosphatemia rickets with the increased Fgf23 and deceased Dmp1 expression, which survived to adulthood. However, there were a few conventional Fam20cD446N knock-in mice died before weaning with the osteosclerotic X-ray radiography. Our results suggested that hypophosphatemia rickets was the predominant phenotype in Fam20c deficient mice, while the lethal osteosclerotic phenotype occasionally took place in the conventional Fam20c mutant mice. This finding implicated that Fam20c deficiency primarily caused hypophosphatemia rickets, but could triggered osteosclerosis in certain context by the alterations in the systems other than skeleton.
Top pruning and phosphorus fertilization increased the probability of high yields and altered the nutrient distribution profile of Pinus massoniana
Authors: Wang Wenyue , Zhang Zhen , Feng Zong ping , WANG Jianchang , ZHOU Zhichun 
Published: October 2024

Abstract

Top pruning is an effective way to produce "orchard-style" forest seed orchards, and phosphorus (P) fertilization can improve the reproductive ability of Masson pine (Pinus massoniana) to some extent. However, it is necessary to determine the absorption and distribution of carbon (C) and nitrogen (N) nutrients by applying phosphorus fertilizer under top pruning. Two clones, high-yielding (209) and low-yielding (225), were tested in a pot experiment with 15N markers during early floral primordium. Calcium magnesium phosphate fertilizer was applied at doses of 0 g/plant (P0), 200 g/plant (P2), and 400 g/plant (P4) to the test plots without top pruning (N-TP) and with top pruning (TP). Overall, top pruning promoted female cone formation in high-yielding P. massoniana clones and significantly affected the downward movement of the fruiting layer, the density of female cones in the lower branches increased by 25.45%~64.97% after top pruning. However, their impact on the formation of female cones in low-yield clones was limited. Top pruning altered the variation of C:N, N:P ratios by increasing C, N and P contents of lower branches. Compared with no top pruning, the C:N ratios of lower branches of 209 and 225 clones increased by 5.79%~27.38% and 2.57%~13.60% after top pruning, respectively. At flowering period, the distribution ratios of N and P in high-yielding female cones increased by 175.0% and 46.3% after top pruning, respectively, indicating that top pruning promoted the absorption of N and P content to female cones. The interaction effect between top pruning and P fertilizer had a significant impact on female cone density, The application of P fertilizer can improve the N harvesting ability of P. massoniana under top-pruning measures, especially by increasing the C:N ratio in the second layer of coniferous branches in the lower part of the tree and promoting the distribution of N to female flower heads, which is beneficial for improving seed yield. On the whole, top pruning causes changes in the spatial structure of trees, affecting the redistribution of nutrients and promoting the distribution of N and P to female cones; The application of phosphorus fertilizer not only regulates the carbon to nitrogen ratio of needles, but also improves the N and P nutrient absorption capacity of P. massoniana under the combination of top pruning measures, which helps to distribute nutrients to organs related to the formation of female cones. The study confirmed that top pruning and phosphorus fertilization increased the probability of high yield and altered the nutrient distribution characteristics in P. massoniana.
Temperature-dependent FTIR spectroscopy of OH defects in Verneuil-grown corundum (α-Al2O3)
Authors: Balan Etienne , Jollands Michael C. , Guillaumet Maxime , Béneut Keevin 
Published: October 2024

Abstract

The temperature dependence of the infrared absorption spectra of two Verneuil-grown corundum samples is investigated in the OH stretching range. The spectra display three main bands at 3184, 3232 and 3309 cm− 1, belonging to the so-called "3309 cm− 1 series", as well as two additional bands at 3163 and 3278 cm− 1 previously reported in some synthetic corundum samples. The anharmonic behavior of the observed bands is analyzed using the pure dephasing model of Persson and Ryberg and depends on the local geometry of the OH defects, which are all associated with Al vacancies. A weak band at 3209 cm− 1 displays anomalous intensity changes with temperature which support a revised interpretation of both the 3209 and 3232 cm− 1 bands. The two bands are interpreted as resulting from the low-temperature equilibrium between two Ti-associated OH defects, enabled by the possibility of hydrogen quantum tunneling within the Al vacancy. The temperature-dependent properties of the 3278 cm− 1 band are similar to those of the other Al-vacancy related defects and a comparison with the theoretical properties of selected OH defects suggests that this band corresponds to the association of the H atom with a non-dissociated Al Frenkel pair. Finally, the properties of the band at 3163 cm− 1 are consistent with its previously proposed association with Si for Al substitution in corundum.
Self-Learning's Impact on Climate Knowledge in Architecture Students
Authors: Idelbi Yamen 
Published: October 2024

Abstract

Self-directed educational technologies are a pivotal element in enhancing students' ability for autonomous and independent learning, as well as in developing their skills in analyzing environmental issues and sustainable design. This study aims to highlight the role of self-learning in architectural education in promoting climate literacy and developing sustainable design skills among students. Problem-solving and decision-making based on dynamic climate variables are considered fundamental goals of self-learning in this field, contributing to the preparation of a generation of innovative architects capable of designing environmentally sustainable and resilient buildings. This study aimed to examine the differences in self-learning skills among architecture students based on variables such as academic level (third year versus fifth year) and nationality (Syrian versus Arab countries) by distributing questionnaires on social media platforms (Appendix 1). The T-Test was used to analyze the significance of differences between the different groups. The results indicated statistically significant differences between third-year and fifth-year students in the practice of certain self-learning skills, such as organized self-learning, problem-solving, and adaptability. The findings favored fifth-year students, suggesting that selecting samples from different academic years reflected substantial changes in acquired skills and knowledge. This approach helped assess the impact of academic progress on the development of these skills. The study revealed no statistically significant differences between Syrian students and students from other Arab countries, indicating that educational methods do not support the climatic knowledge aspect. Therefore, the study recommends reassessing architectural design education methods in light of natural disasters and advancements in artificial intelligence.
pyOpenMS-viz: Streamlining Mass Spectrometry Data Visualization with pandas
Authors: Sing Justin , Charkow Joshua , Walter Axel , Gao Mingxuan , Muller Tom David , Bittremieux Wout , Sachsenberg Timo , Röst Hannes 
Published: October 2024

Abstract

Mass spectrometry data visualization is essential for a wide range of applications, such as validation of workflows and results, benchmarking new algorithms, and creating comprehensive quality control reports. Python offers a popular and powerful framework for analyzing and visualizing multidimensional data; however, generating commonly used mass spectrometry plots in Python can be cumbersome. Here we present pyOpenMS-viz, a versatile, unified framework for generating mass spectrometry plots. pyOpenMS-viz directly extends pandas DataFrame plotting for generating figures in a single line of code. This implementation enables easy integration across various Python-based mass spectrometry tools that already use pandas DataFrames to store MS data. pyOpenMS-viz is open-source under a BSD 3-Clause license and freely available at https://github.com/OpenMS/pyopenms_viz.
Virtual reality-assisted therapy targeting persistent auditory verbal hallucinations in patients diagnosed with schizophrenia spectrum disorders: the Challenge single-blind, randomized clinical trial
Authors: Glenthøj Louise , Smith Lisa , Vernal Ditte , Mariegaard Lise , Christensen Annette , Jansen Jens , Schytte Gry , Stokbro Louise , Albert Nikolai , Christensen Mads , Thomas Neil , Hjorthøj Carsten , Nordentoft Merete 
Published: October 2024

Abstract

Auditory verbal hallucinations (AVH) are frequent and debilitating symptoms of schizophrenia spectrum disorders (SSD). In the current randomized, assessor-blinded, parallel-group superiority clinical trial, a total of 270 participants, diagnosed with SSD suffering from treatment-resistant AVH, were randomly assigned to seven sessions of either a virtual reality-assisted therapy (Challenge-VRT) or supportive counselling. Assessment of outcome was conducted at baseline, and at 12 and 24 weeks post baseline. Linear mixed model analyses demonstrated that Challenge-VRT significantly reduced the symptom load of AVH on the primary outcome measured with the Psychotic Symptoms Rating Scales (PSYRATS-AH total, adjusted mean difference: -2.26, 95% Cl: -4.26 to -0.25, p = 0.03) and the secondary outcome measure on frequency of AVH (PSYRATS-Frequency, adjusted mean difference: -0.84, 95% Cl: -1.53 to -0.14, p = 0.02) at treatment cessation 12 weeks post baseline. We conclude that the brief Challenge-VRT is a viable new treatment method for reducing the severity of AVH.
ClinicalTrials.gov identifier NCT04661163
Boosting or Busting: The Impact of Industrial Zones on Local Income Dynamics and Labor Outcomes in Vietnam
Authors: Nguyen Khanh 
Published: October 2024

Abstract

This paper investigates the empirical relationship between the establishment of industrial zones and labor outcomes in Vietnam, focusing on variables such as local income inequality, levels of household annual income and expenditure per capita, hourly wages, and share of labor income. Using commune-level panel data constructed from Vietnam's national household survey dataset and a staggered event estimation strategy, the establishment of IZs leads to an increase in individual wage inequality, especially for women; a slight increase in hourly wages and share of labor income, but a decrease in expenditure per capita and rising house value. Policies ensuring fair wages and access to essential amenities, social safety net programs to assist vulnerable workers and reduce income disparities, and regulations to support female workers are recommended.
Virtual Numerical Control: An Approach Towards Autonomous Manufacturing with a Case Study in Welding
Authors: Asy Mohab M. 
Published: October 2024

Abstract

Today's customer lifestyles have reshaped their expectations and preferences, driving a growing demand for tailor-made products. While current conventional manufacturing (MNF) systems are robust, they often lack the flexibility needed to accommodate customization. Most MNF systems, despite advances in technology and machinery, still rely on executing predefined instructions, limiting their flexibility. In contrast, human workers excel at handling product variations due to their cognitive abilities, which allow them to perceive, analyze, and make appropriate decisions to adapt to changing conditions. This study introduces Virtual Numerical Control (VNC) as a solution to upgrade MNF systems and overcome these limitations. VNC aims to transform MNF systems into cognitive entities capable of autonomous decision-making, enabling greater flexibility to meet customization demands. To demonstrate the potential of VNC, we implemented it in a welding system as a practical case study. The results showed that VNC enabled the system to operate autonomously. It accurately identified the shape of the objects to be welded, determined the appropriate welding paths, and executed them with high precision, all without human intervention. This highlights the significant potential of VNC technology for broader applications in industrial automation in welding and beyond.
Cloud-Enabled Microservices Architecture for Next-Generation Online Airlines Reservation Systems
Authors: Barua Biman , Kaiser M. Shamim 
Published: October 2024

Abstract

With the growing demand for real-time, scalable, and reliable airline reservation systems, it is essential to provide advanced architectural solutions for modern software development. Existing monolithic architecture is facing challenges to overcome the issue when there is high traffic with accessing data from multiple locations or sources like GDS, LCC and flight APIs. This paper presents a Cloud-Enabled Microservices Architecture (CEMA) for a subsequent-generation online airline reservation systems. The proposed architecture integrates Global Distribution Systems (GDS), Low-Cost Carriers (LCC), and Flight APIs. Which will improve scalability, fault tolerance, and overall performance. By decoupling services including flight search, reserving, fee, and notification, the system allows unbiased scaling and higher aid utilization. During overall performance assessments, the system treated up to 10,000 concurrent users, preserving a median reaction time of 590 ms below peak time load. The flight service provider tested a 45% improvement in response time, lowering latency from 480 ms to 250 ms below minimum load conditions. Failure checking out showed that the system recovered from microservice failures in underneath 200 ms, ensuring high availability. In load testing out, the booking microservice processed 1,000 bookings, consistent with a 95% issuing success rate. Additionally, the architecture executed 99.9% uptime, making sure continuous service shipping even at some point of peak visitors’ periods. The integration of GDS and LCC APIs improved the systems inventory insurance by using 35%, presenting users with a broader selection of flights. This study demonstrates that a microservices-primarily based approach can considerably enhance the efficiency and scalability of online airline reservation systems.
Agricultural dry residues management stretegies and its potential for Biogas Production
Authors: Jadhav Gururaj Bharat , Chaudhary* Indra Jeet 
Published: October 2024

Abstract

Anaerobic digestion reactions can be used to produce biogas from sources of agricultural waste. The ecology has been harmed by fossil fuels, while biogas solves environmental and climate change-related problems. The goals of biorefineries, global warming, nutrient recycling, and greenhouse gas reduction come after the techno-economic study of biogas production. Furthermore, various metabolic reactions, the use of various microbes, filtration, upgrading, and CO2 removal from the gas mixture procedures all play a role in the creation of biogas. Agricultural wastes are important sources for the production of biogas. Biogas or bio methane generation relieves the negative impact of fossil fuels and agro wastes. Biogas can be generated from agro-industrial wastes with lignin, cellulose and hemicellulose. An very promising method for handling agricultural waste that reduces pollution and produces energy effectively is anaerobic digestion. Therefore present study was conducted for screening of bio-waste for biogas generation. Resultants in all three digesters gas generation was found in sorghum than wheat straw while coconut shows the least gas generation. Study also found that higher gas production was seen at 21 DAD (day after digestion). The study concluded that agricultural wastes are important sources for the production of biogas. Therefore selection of most cellulosic agricultural plants will be helpful for biogas production and also relieve the negative impact of fossil fuels and agro wastes.
Challenges of water environment governance in China: based on a qualitative comparative analysis approach
Authors: Zhu Xiaoli , Sun Zhongrui , Zhang Wanli 
Published: October 2024

ABSTRACT
As a developing country focused on water pollution control, understanding the mechanisms behind China's water environment governance challenges is crucial. This study uses fuzzy set qualitative comparative analysis (fs/QCA) to develop a localized political-economic-social-technological (PEST) framework tailored to local governance realities, analyzing cases from the second round of Central Environmental Protection Inspection (CEPI). Two critical paths of local water governance challenges (CWEG) are identified: (1) In the 'government capacity constraints” path, stable yet limited official autonomy, combined with weak social supervision, obscures the institutional environment's empowering role and restricts local governance capacity, hindering environmental management effectiveness. (2) In the 'formalism in governance' path, a strong institutional environment, significant fiscal decentralization, robust digital infrastructure, green technology innovation, and low official turnover create a favorable governance environment. However, under the logic of avoiding accountability, formalism may emerge, posing challenges to effective water resource management.
Investigating Challenges of Individuals with Autism Spectrum Disorder During and Post COVID-19, and Practical Suggestions for Parents and Caregivers on How to Tackle Challenges: A Systematic Review Article
Authors: Nasiri Amirpeyman , Entezari Fatemeh , Karimi Maryam , Naghibi Narges , Golshan Faly , Sabzalizadeh Mansoureh , Afarinesh Mohammad Reza 
Published: October 2024

Introduction:
The first and second waves of COVID-19 were unprecedented
situations that caused turmoil in everyone’s life, especially for individuals
with autism spectrum disorder (ASD) who were severely affected by the
transition.

Objective:
This article investigates the major impacts of COVID-19 transitioning
on individuals in the spectrum followed by recommendations for autistic
families on addressing concerns caused by post-COVID adaptations. We have
based our study on the most recent investigations of challenges and solutions
provided for these individuals in COVID and post-COVID-19 transitions. We
will also explain telehealth as the most practical available solution and describe
its possible advantages and disadvantages. The articles have been selected from
PubMed, Google Scholar, etc. according to the goals stated above.

Results:
According to our study, psychological problems, economic problems,
reduced physical activity, sleep disorders, malnutrition, non-cooperation of children
with ASD, and speech therapy were the most important challenges for people
with ASD as well as their families and caregivers during the COVID-19 pandemic.

Conclusion:
It was concluded the use of telehealth could be a suitable platform
for many educational methods such as applied behavior analysis, visual programs,
speech therapy, family positive reinforcement systems, etc. to overcome
these challenges. However, this method also has certain limitations, and therefore
a combination of face-to-face and telehealth methods is recommended to
help patients.