bluuebunny/crossref_metadata_2025_split huggingface dataset:
Small cavity creation in the vertebral body reduces the rate of cement leakage during vertebroplasty
Authors: Arabmotlagh Mohammad , Rickert Marcus , Lukas Alexander , Rauschmann Michael , Fleege Christoph 
Published: February 2016

ABSTRACTCement leakage is the most common complication during vertebroplasty and may result in serious morbidity. Measures to reduce the rate of cement leakage are valuable ways to improve vertebroplasty safety. The present study aimed to evaluate whether creating a small cavity in the vertebral body prior to cement injection would reduce the rate of cement leakage during vertebroplasty. The study included 36 consecutive patients with 42 painful osteoporotic vertebral body compression fractures that were classified as A1 fractures according to AO classification. Patients were randomly assigned to receive either treatment with vertebroplasty (control) or with a procedure termed cavuplasty, in which a small cavity was created in the vertebral body prior to cement injection. CT scanning was performed to detect cement leakage. Cement leakage was observed in 14 (66.6%) of the 21 vertebral bodies treated with vertebroplasty and 5 (23.8%) of the 21 vertebral bodies treated with cavuplasty (p = 0.012). These results suggest that the creation of a small cavity in the vertebral body prior to cement injection is an effective way to reduce cement leakage during vertebroplasty. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:154–159, 2017.
Optimization of microwave‐assisted extraction (MAE) of coriander phenolic antioxidants – response surface methodology approach
Authors: Zeković Zoran , Vladić Jelena , Vidović Senka , Adamović Dušan , Pavlić Branimir 
Published: February 2016

AbstractBACKGROUNDMicrowave‐assisted extraction (MAE) of polyphenols from coriander seeds was optimized by simultaneous maximization of total phenolic (TP) and total flavonoid (TF) yields, as well as maximized antioxidant activity determined by 1,1‐diphenyl‐2‐picrylhydrazyl and reducing power assays. Box–Behnken experimental design with response surface methodology (RSM) was used for optimization of MAE. Extraction time (X1, 15–35 min), ethanol concentration (X2, 50–90% w/w) and irradiation power (X3, 400–800 W) were investigated as independent variables. Experimentally obtained values of investigated responses were fitted to a second‐order polynomial model, and multiple regression analysis and analysis of variance were used to determine fitness of the model and optimal conditions.RESULTSThe optimal MAE conditions for simultaneous maximization of polyphenol yield and increased antioxidant activity were an extraction time of 19 min, an ethanol concentration of 63% and an irradiation power of 570 W, while predicted values of TP, TF, IC50 and EC50 at optimal MAE conditions were 311.23 mg gallic acid equivalent per 100 g dry weight (DW), 213.66 mg catechin equivalent per 100 g DW, 0.0315 mg mL−1 and 0.1311 mg mL−1 respectively.CONCLUSIONRSM was successfully used for multi‐response optimization of coriander seed polyphenols. Comparison of optimized MAE with conventional extraction techniques confirmed that MAE provides significantly higher polyphenol yields and extracts with increased antioxidant activity. © 2016 Society of Chemical Industry
The effect of oregano essential oil on microbial load and sensory attributes of dried meat
Authors: Hernández Helga , Fraňková Adéla , Sýkora Tomáš , Klouček Pavel , Kouřimská Lenka , Kučerová Iva , Banout Jan 
Published: February 2016

AbstractBackgroundMicrobial load can be controlled using either synthetic or natural preservatives. Particular interest has been focused on the potential application of plant essential oils as safer additives for meat. However, there is no published research on the use of essential oils during the meat drying process. This study was focused on enhancing the meat drying process by using oregano essential oil (OEO) to inhibit the growth of bacteria and thus obtain a value‐added dried meat product. The sensory response from assessors is presented.ResultsIt was found that the application of OEO in meat was effective in inhibiting Salmonella enteritidis and Escherichia coli. After 6 h of drying at 55 °C, 2 mL (0.038 mL L−1 air) and 1.5 mL (0.028 mL L−1 air) of OEO were considered as the minimal inhibitory concentrations (MICs) against S. enteritidis and E. coli respectively. Samples treated with 0.75 mL of OEO were more attractive for consumption compared with the control; at a higher concentration of OEO, the sensory quality of the food was affected.ConclusionA value‐added dried meat product obtained by using OEO to enhance food safety received an acceptable sensory response from consumers. © 2016 Society of Chemical Industry
Impressive Rate Raise of the Hydrosilation Reaction Through UV‐Activation: Energy and Time Saving
Authors: Marchi Sophie , Sangermano Marco , Ligorio Davide , Meier Patrick , Kornmann Xavier 
Published: February 2016

Silicone materials are widely used in many fields such as electrical or food industries and their consumption is constantly growing. They are generally cured by vulcanization reaction for long time at high temperatures which requires high energy consumption. The possibility to achieve the polymerization of silicone rubbers by UV‐activation promotes the reduction of both time and temperature leading to an impressive energy saving. Indeed, this process is more than 30 times faster than the thermal one. Moreover, the properties of the two resulting materials are comparable, indicating that the low time of UV‐activated hydrosilation reaction is suitable for the formation of crosslinked silicone polymers.image
Scalability of Coarse‐Grained Potentials Generated from Iterative Boltzmann Inversion for Polymers: Case Study on Polycarbonates
Authors: Choudhury Chandan Kumar , Carbone Paola , Roy Sudip 
Published: February 2016

Using systematic coarse‐grained (CG) techniques such as iterative Boltzmann inversion (IBI) is an efficient means to simulate high molecular weight polymer melts within reasonable computational time. One drawback of such an approach is however the need to carry out extensive atomistic simulations in order to extrapolate the necessary distributions to derive the inter and intrabead force field parameters. Here it is shown that it is possible to use atomistic simulations of relative short oligomers to develop the CG model for high molecular weight polymers. In particular for the specific case of polycarbonates, it is found that the structural properties (end‐to‐end distance, radius of gyration and their distributions) are similar irrespective of whether the CG potentials are derived from 5‐mer or 10‐mer melt systems. Dynamical properties of the CG systems are smoother and faster than the atomistic ones. Scaling factor, derived by overlapping the CG mean square displacement curves (obtained from different CG IBI potentials) over the atomistic ones, also scales the autocorrelation functions. A prediction of the dynamical scaling factor in the case of the unavailability of atomistic simulations is also discussed. The dynamical properties of the CG melts are modeled reasonably well by all the CG potentials derived from atomistic simulations of short oligomers.
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FliH and FliI ensure efficient energy coupling of flagellar type III protein export in Salmonella
Authors: Minamino Tohru , Kinoshita Miki , Inoue Yumi , Morimoto Yusuke V. , Ihara Kunio , Koya Satomi , Hara Noritaka , Nishioka Noriko , Kojima Seiji , Homma Michio , Namba Keiichi 
Published: February 2016

AbstractFor construction of the bacterial flagellum, flagellar proteins are exported via its specific export apparatus from the cytoplasm to the distal end of the growing flagellar structure. The flagellar export apparatus consists of a transmembrane (TM) export gate complex and a cytoplasmic ATPase complex consisting of FliH, FliI, and FliJ. FlhA is a TM export gate protein and plays important roles in energy coupling of protein translocation. However, the energy coupling mechanism remains unknown. Here, we performed a cross‐complementation assay to measure robustness of the energy transduction system of the export apparatus against genetic perturbations. Vibrio FlhA restored motility of a Salmonella ΔflhA mutant but not that of a ΔfliH‐fliI flhB(P28T) ΔflhA mutant. The flgM mutations significantly increased flagellar gene expression levels, allowing Vibrio FlhA to exert its export activity in the ΔfliH‐fliI flhB(P28T) ΔflhA mutant. Pull‐down assays revealed that the binding affinities of Vibrio FlhA for FliJ and the FlgN–FlgK chaperone–substrate complex were much lower than those of Salmonella FlhA. These suggest that Vibrio FlhA requires the support of FliH and FliI to efficiently and properly interact with FliJ and the FlgN–FlgK complex. We propose that FliH and FliI ensure robust and efficient energy coupling of protein export during flagellar assembly.
Role of bacteria in the production and degradation of Microcystis cyanopeptides
Authors: Briand Enora , Humbert Jean‐François , Tambosco Kevin , Bormans Myriam , Gerwick William H. 
Published: February 2016

AbstractThe freshwater cyanobacteria, Microcystis sp., commonly form large colonies with bacteria embedded in their mucilage. Positive and negative interactions between Microcystis species and their associated bacteria have been reported. However, the potential role of bacteria in the production and degradation of cyanobacterial secondary metabolites has not been investigated. In this study, a Microcystis‐associated bacterial community was isolated and added to the axenic M. aeruginosaPCC7806 liquid culture. After 3 years of cocultivation, we studied the bacterial genetic diversity adapted to the PCC7806 strain and compared the intra‐ and extracellular concentration of major cyanopeptides produced by the cyanobacterial strain under xenic and axenic conditions. Mass spectrometric analyses showed that the intracellular concentration of peptides was not affected by the presence of bacteria. Interestingly, the produced peptides were detected in the axenic media but could not be found in the xenic media. This investigation revealed that a natural bacterial community, dominated by Alpha‐proteobacteria, was able to degrade a wide panel of structurally varying cyclic cyanopeptides.
Clinical translation of ferumoxytol‐based vessel size imaging (VSI): Feasibility in a phase I oncology clinical trial population
Authors: Fredrickson Jill , Serkova Natalie J. , Wyatt Shelby K. , Carano Richard A.D. , Pirzkall Andrea , Rhee Ina , Rosen Lee S. , Bessudo Alberto , Weekes Colin , de Crespigny Alex 
Published: February 2016

PurposeTo assess the feasibility of acquiring vessel size imaging (VSI) metrics using ferumoxytol injections and stock pulse sequences in a multicenter Phase I trial of a novel therapy in patients with advanced metastatic disease.MethodsScans were acquired before, immediately after, and 48 h after injection, at screening and after 2 weeks of treatment. ΔR2,
, vessel density (Q), and relative vascular volume fractions (VVF) were estimated in both normal tissue and tumor, and compared with model‐derived theoretical and experimental estimates based on preclinical murine xenograft data.ResultsR2 and
relaxation rates were still significantly elevated in tumors and liver 48 h after ferumoxytol injection; liver values returned to baseline by week 2. Q was relatively insensitive to changes in
, indicating lack of dependence on contrast agent concentration. Variability in Q was higher among human tumors compared with xenografts and was mostly driven by ΔR2. Relative VVFs were higher in human tumors compared with xenografts, while values in muscle were similar between species.ConclusionClinical ferumoxytol‐based VSI is feasible using standard MRI techniques in a multicenter study of patients with lesions outside of the brain. Ferumoxytol accumulation in the liver does not preclude measurement of VSI parameters in liver metastases. Magn Reson Med 77:814–825, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Speeding up dynamic spiral chemical shift imaging with incoherent sampling and low‐rank matrix completion
Authors: DeVience Stephen J. , Mayer Dirk 
Published: February 2016

PurposeTo improve the temporal and spatial resolution of dynamic 13C spiral chemical shift imaging via incoherent sampling and low‐rank matrix completion (LRMC).MethodsSpiral CSI data were both simulated and acquired in rats, and undersampling was implemented retrospectively and prospectively by pseudorandomly omitting a fraction of the spiral interleaves. Undersampled data were reconstructed with both LRMC and a conventional inverse nonuniform fast Fourier transform (iNUFFT) and compared with fully sampled data.ResultsTwo‐fold undersampling with LRMC reconstruction enabled a two‐fold improvement in temporal or spatial resolution without significant artifacts or spatiotemporal distortion. Conversely, undersampling with iNUFFT reconstruction created strong artifacts that obscured the image. LRMC performed better at time points with strong metabolite signal.ConclusionIncoherent undersampling and LRMC provides a way to increase the spatiotemporal resolution of spiral CSI without degrading data integrity. Magn Reson Med 77:951–960, 2017. © 2016 International Society for Magnetic Resonance in Medicine
Spinal Mobility in Axial Spondyloarthritis: A Cross‐Sectional Clinical Study
Authors: Mogard Elisabeth , Lindqvist Elisabet , Bergman Stefan , Bremander Ann 
Published: February 2016

AbstractObjectiveResearch concerning spinal mobility in axial spondyloarthritis (axSpA) has focused on ankylosing spondylitis (AS), and data on the clinical diagnosis of undifferentiated spondyloarthritis (USpA) are limited. The objective was to study differences in spinal mobility between axSpA subgroups AS and USpA, including gender differences.MethodsA total of 183 patients with axSpA from a rheumatology clinic were included in the study. The earliest recorded spinal mobility measures (cervical rotation/flexion/extension/lateral flexion, tragus‐to‐wall distance, vital capacity, chest expansion, thoracic flexion, thoracolumbar flexion, lateral spinal flexion, lumbar flexion and intermalleolar distance) were obtained by specialized physiotherapists. Differences between subgroups were analysed using analysis of covariance, controlled for gender and disease duration.ResultsIn the USpA group (n = 57), the mean [standard deviation (SD)] age was 41.6 (11.4) years, and disease duration was 13 (10.6) years, with 54% men. In the AS group (n = 126), the mean (SD) age was 48.4 (13.5) years, and disease duration 24.6 (13.3) years, with 77% men. Spinal mobility was less restricted in USpA versus AS patients (p ≤ 0.05), with a median (interquartile range) tragus‐to‐wall distance of 11 (10–12) cm versus 13 (11.3–18.5) cm; thoracolumbar flexion 9 (7–10) cm versus 6.5 (4–9) cm; lateral spinal flexion 29 (25–36) cm versus 21.3 (12–31) cm; lumbar flexion 4.5 (3.5–5.0) cm versus 3.5 (2.0–4.5) cm and intermalleolar distance 113 (102–121) cm versus 101 (86–114) cm. There were no differences between the subgroups in cervical mobility, vital capacity, chest expansion or thoracic flexion, and there were few gender differences, besides anthropometric measures.ConclusionPatients with USpA and AS had similar cervical and chest mobility, while thoracic and lumbar mobility were more severely restricted in AS. There were few gender differences in either subgroup. Further studies, to understand the full impact of USpA on spinal mobility, are needed. Copyright © 2016 John Wiley & Sons, Ltd.
ProTru: a provenance‐based trust architecture for wireless sensor networks
Authors: Dogan Gulustan 
Published: February 2016

SummaryTrust is an important component of wireless sensor networks for believability of the produced data, and trust history is a crucial asset in deciding trust of the data. In this paper, we show how provenance can be used for registering previous trust records and other information such as node type, data type, and node location. Our aim is to design a distributed trust‐enhancing architecture using only local provenance during sensor fusion with a low communication overhead. Our network is cognitive in the sense that our system reacts automatically upon detecting low trust. Copyright © 2016 John Wiley & Sons, Ltd.
Isogeometric analysis of fluid‐saturated porous media including flow in the cracks
Authors: Vignollet J. , May S. , Borst R. de 
Published: February 2016

SummaryAn isogeometric model is developed for the analysis of fluid transport in pre‐existing faults or cracks that are embedded in a fluid‐saturated deformable porous medium. Flow of the interstitial fluid in the porous medium and fluid transport in the discontinuities are accounted for and are coupled. The modelling of a fluid‐saturated porous medium in general requires the interpolation of the displacements of the solid to be one order higher than that of the pressure of the interstitial fluid. Using order elevation and Bézier projection, a consistent procedure has been developed to accomplish this in an isogeometric framework. Particular attention has also been given to the spatial integration along the isogeometric interface element in order to suppress traction oscillations that can arise for certain integration rules when a relatively high dummy stiffness is used in a poromechanical model. © 2016 The Authors. International Journal for Numerical Methods in Engineering Published by John Wiley & Sons Ltd.
Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans
Authors: Tonks Katherine T. , Coster Adelle CF , Christopher Michael J. , Chaudhuri Rima , Xu Aimin , Gagnon‐Bartsch Johann , Chisholm Donald J. , James David E. , Meikle Peter J. , Greenfield Jerry R. , Samocha‐Bonet Dorit 
Published: February 2016

ObjectiveAlterations in lipids in muscle and plasma have been documented in insulin‐resistant people with obesity. Whether these lipid alterations are a reflection of insulin resistance or obesity remains unclear.MethodsNondiabetic sedentary individuals not treated with lipid‐lowering medications were studied (n = 51). Subjects with body mass index (BMI) > 25 kg/m2 (n = 28) were stratified based on median glucose infusion rate during a hyperinsulinemic‐euglycemic clamp into insulin‐sensitive and insulin‐resistant groups (above and below median, obesity/insulin‐sensitive and obesity/insulin‐resistant, respectively). Lean individuals (n = 23) served as a reference group. Lipidomics was performed in muscle and plasma by liquid chromatography electrospray ionization‐tandem mass spectrometry. Pathway analysis of gene array in muscle was performed in a subset (n = 35).ResultsIn muscle, insulin resistance was characterized by higher levels of C18:0 sphingolipids, while in plasma, higher levels of diacylglycerol and cholesterol ester, and lower levels of lysophosphatidylcholine and lysoalkylphosphatidylcholine, indicated insulin resistance, irrespective of overweight/obesity. The sphingolipid metabolism gene pathway was upregulated in muscle in insulin resistance independent of obesity. An overweight/obesity lipidomic signature was only apparent in plasma, predominated by higher triacylglycerol and lower plasmalogen species.ConclusionsMuscle C18:0 sphingolipids may play a role in insulin resistance independent of excess adiposity.
Effectiveness of a Pharmacist‐Physician Team‐Based Collaboration to Improve Long‐Term Blood Pressure Control at an Inner‐City Safety‐Net Clinic
Authors: Sisson Evan M. , Dixon Dave L. , Kildow D. Cole , Van Tassell Benjamin W. , Carl Daniel E. , Varghese Della , Electricwala Batul , Carroll Norman V. 
Published: February 2016

PurposeTo evaluate the effectiveness of a pharmacist‐physician collaborative practice model (PPCPM) to improve long‐term blood pressure (BP) control rates in a primarily African‐American underserved urban population.Practice InnovationVolunteer physicians established initial diagnoses, whereas pharmacists provided most (more than 70%) of the medication management. During each scheduled visit, the pharmacist reconciled the medication list, completed a clinical interview, conducted a focused physical examination, developed and implemented a treatment plan, and provided documentation in a shared medical record.EvaluationA retrospective chart review was performed to collect data for a longitudinal cohort of patients managed by the PPCPM from 2010–2013.ResultsOf 385 patients with at least two pharmacist visits during 2009, 172 patients received continuous care over the study period. At baseline, the mean age of the cohort was 51.3 years, 62% were female, and 76% were African‐American. Approximately 65% were obese (body mass index 30 kg/m2 or higher), and 39% were cigarette smokers. Mean baseline BP was 156/98 mm Hg, with only 17% of the cohort at their BP goal of lower than 140/90 mm Hg. The BP control rate improved to 66% during the first year and persisted throughout the study period, with 68% of patients at goal in 2013 (p<0.05 compared with baseline).ConclusionThe PPCPM BP control rate ranks in the 90th percentile of National Committee for Quality Assurance benchmarks and was superior even to the 2013 reported mean for commercial insurers. The PPCPM effectively improved hypertension control in an uninsured, primarily African‐American, urban population despite significant health barriers. Key elements of this asynchronous care model included access to a common medical record, optimization of distinct interprofessional roles, frequent follow‐up with evaluation, and collaborative practice agreement with sufficient scope of practice to implement medication changes at the time of the visit.
A side‐by‐side comparison of CPV module and system performance
Authors: Muller Matthew , Marion Bill , Kurtz Sarah , Ghosal Kanchan , Burroughs Scott , Libby Cara , Enbar Nadav 
Published: February 2016

AbstractA side‐by‐side comparison is made between concentrator photovoltaic module and system direct current aperture efficiency data with a focus on quantifying system performance losses. The individual losses measured/calculated, when combined, are in good agreement with the total loss seen between the module and the system. Results indicate that for the given test period, the largest individual loss of 3.7% relative is due to the baseline performance difference between the individual module and the average for the 200 modules in the system. A basic empirical model is derived based on module spectral performance data and the tabulated losses between the module and the system. The model predicts instantaneous system direct current aperture efficiency with a root mean square error of 2.3% relative. Copyright © 2016 John Wiley & Sons, Ltd.