bluuebunny/crossref_metadata_2025_split huggingface dataset:
Repeated-Sprint Ability in Division I Collegiate Male Soccer Players: Positional Differences and Relationships With Performance Tests
Authors: Lockie Robert G. , Moreno Matthew R. , Orjalo Ashley J. , Stage Alyssa A. , Liu Tricia M. , Birmingham-Babauta Samantha A. , Hurley Jillian M. , Torne Ibett A. , Beiley Megan D. , Risso Fabrice G. , Davis DeShaun L. , Lazar Adrina , Stokes John J. , Giuliano Dominic V. 
Published: October 2017

Abstract
Lockie, RG, Moreno, MR, Orjalo, AJ, Stage, AA, Liu, TM, Birmingham-Babauta, SA, Hurley, JM, Torne, IA, Beiley, MD, Risso, FG, Davis, DL, Lazar, A, Stokes, JJ, and Giuliano, DV. Repeated-sprint ability in Division I collegiate male soccer players: positional differences and relationships with performance tests. J Strength Cond Res 33(5): 1362–1370, 2019—Repeated-sprint ability (RSA) in essential for soccer. Important considerations when assessing RSA is whether there are differences between positions (defenders, midfielders, and forwards), and what physiological characteristics may contribute to RSA. This has not been assessed in collegiate male players. Eighteen Division I male field players from one school performed several performance tests. The RSA test involved 7 × 30-m sprints completed on 20-second cycles. Measurements included total time (TT), and performance decrement (percent change in time from the first to last sprint; PD). Subjects also completed tests of lower-body power (vertical [VJ] and standing broad jump [SBJ]); linear (30-m sprint; 0–5 m, 0–10 m, 0–30 m intervals) and change-of-direction (505) speed; and soccer-specific endurance (Yo-Yo Intermittent Recovery Test Level 2; YYIRT2). A one-way analysis of variance (p < 0.05) determined between-position differences, and effect sizes were calculated. Pearson's correlations (p < 0.05) calculated relationships between RSA TT and PD with the other tests. There were no significant between-position differences for any test. There were large effects for the faster right-leg 505 and greater YYIRT2 distance for midfielders compared with defenders and forwards. Nonetheless, no between-position differences in RSA TT and PD were documented. There were relationships between RSA TT and the VJ (r = −0.59), SBJ (r = −0.61), 0–10 m (r = 0.64) and 0–30-m (r = 0.83) sprint intervals. There were no significant correlations for RSA PD. Male field players from one collegiate soccer team can demonstrate similar RSA across different positions. Greater lower-body power and sprinting speed could augment RSA.
Relationships Between Height, Arm Length, and Leg Length on the Mechanics of the Conventional and High-Handle Hexagonal Bar Deadlift
Authors: Lockie Robert G. , Moreno Matthew R. , Orjalo Ashley J. , Lazar Adrina , Liu Tricia M. , Stage Alyssa A. , Birmingham-Babauta Samantha A. , Stokes John J. , Giuliano Dominic V. , Risso Fabrice G. , Davis DeShaun L. , Callaghan Samuel J. 
Published: October 2017

Abstract
Lockie, RG, Moreno, MR, Orjalo, AJ, Lazar, A, Liu, TM, Stage, AA, Birmingham-Babauta, SA, Stokes, JJ, Giuliano, DV, Risso, FG, Davis, DL, and Callaghan, SJ. Relationships between height, arm length, and leg length on the mechanics of the conventional and high-handle hexagonal bar deadlift. J Strength Cond Res 32(11): 3011–3019, 2018—The study investigated relationships between arm length (AL) and leg length (LL) and conventional deadlift (CD) and high-handle hexagonal bar deadlift (HHBD) mechanics. Twenty-three resistance-trained subjects (14 men and 9 women) completed a 1 repetition maximum CD and HHBD. A linear position transducer was used to measure lift distance and duration; peak and mean power, velocity, and force; time to peak power and velocity; and work. Right AL and LL were measured, and AL-to-LL ratio (AL:LL) was also calculated. Spearman's correlations (ρ; p ≤ 0.05) computed relationships between anthropometry and deadlift mechanics separately for men and women. For the HHBD, greater height and LL related to greater lift distance and work (ρ = 0.54–0.68); a higher AL:LL related to time to peak power and velocity occurring sooner (ρ = -0.67 to 0.78). For the HHBD, greater height and LL related to greater lift distance and work; a higher AL:LL related to time to peak power and velocity occurring sooner in the lift (ρ = 0.54–0.77). In women, greater height, AL, and LL related to a longer CD lift distance (ρ = 0.67–0.92). For the HHBD, greater height, AL, and LL related to a longer lift distance and greater mean velocity (ρ = 0.69–0.96). There was a negative relationship between AL and lift time (ρ = −0.83), which meant longer arms resulted in a lower HHBD lift time. Arm length may have influenced women more because of the fixed dimensions of the hexagonal bar. Coaches should be cognizant of potential differences in CD and HHBD work when performed by individuals of different body sizes.
ABLE: An Activity-Based Level Set Segmentation Algorithm for Two-Photon Calcium Imaging Data
Authors: Reynolds Stephanie , Abrahamsson Therese , Schuck Renaud , Sjöström P. Jesper , Schultz Simon R. , Dragotti Pier Luigi 
Published: October 2017

AbstractWe present an algorithm for detecting the location of cells from two-photon calcium imaging data. In our framework, multiple coupled active contours evolve, guided by a model-based cost function, to identify cell boundaries. An active contour seeks to partition a local region into two subregions, a cell interior and exterior, in which all pixels have maximally “similar” time courses. This simple, local model allows contours to be evolved predominantly independently. When contours are sufficiently close, their evolution is coupled, in a manner that permits overlap. We illustrate the ability of the proposed method to demix overlapping cells on real data. The proposed framework is flexible, incorporating no prior information regarding a cell’s morphology or stereotypical temporal activity, which enables the detection of cells with diverse properties. We demonstrate algorithm performance on a challenging mousein vitrodataset, containing synchronously spiking cells, and a manually labelled mousein vivodataset, on which ABLE (the proposed method) achieves a 67.5% success rate.
An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration
Authors: Huang Claire Yu-Mei , Zhang Chuansheng , Zollinger Daniel R. , Leterrier Christophe , Rasband Matthew N. 
Published: October 2017

Axons must withstand mechanical forces, including tension, torsion, and compression. Spectrins and actin form a periodic cytoskeleton proposed to protect axons against these forces. However, because spectrins also participate in assembly of axon initial segments (AISs) and nodes of Ranvier, it is difficult to uncouple their roles in maintaining axon integrity from their functions at AIS and nodes. To overcome this problem and to determine the importance of spectrin cytoskeletons for axon integrity, we generated mice with αII spectrin-deficient peripheral sensory neurons. The axons of these neurons are very long and exposed to the mechanical forces associated with limb movement; most lack an AIS, and some are unmyelinated and have no nodes. We analyzed αII spectrin-deficient mice of both sexes and found that, in myelinated axons, αII spectrin forms a periodic cytoskeleton with βIV and βII spectrin at nodes of Ranvier and paranodes, respectively, but that loss of αII spectrin disrupts this organization.Avil-cre;Sptan1f/fmice have reduced numbers of nodes, disrupted paranodal junctions, and mislocalized Kv1 K+channels. We show that the density of nodal βIV spectrin is constant among axons, but the density of nodal αII spectrin increases with axon diameter. Remarkably,Avil-cre;Sptan1f/fmice have intact nociception and small-diameter axons, but severe ataxia due to preferential degeneration of large-diameter myelinated axons. Our results suggest that nodal αII spectrin helps resist the mechanical forces experienced by large-diameter axons, and that αII spectrin-dependent cytoskeletons are also required for assembly of nodes of Ranvier.SIGNIFICANCE STATEMENTA periodic axonal cytoskeleton consisting of actin and spectrin has been proposed to help axons resist the mechanical forces to which they are exposed (e.g., compression, torsion, and stretch). However, until now, no vertebrate animal model has tested the requirement of the spectrin cytoskeleton in maintenance of axon integrity. We demonstrate the role of the periodic spectrin-dependent cytoskeleton in axons and show that loss of αII spectrin from PNS axons causes preferential degeneration of large-diameter myelinated axons. We show that nodal αII spectrin is found at greater densities in large-diameter myelinated axons, suggesting that nodes are particularly vulnerable domains requiring a specialized cytoskeleton to protect against axon degeneration.
Delayed Maturation of Fast-Spiking Interneurons Is Rectified by Activation of the TrkB Receptor in the Mouse Model of Fragile X Syndrome
Authors: Nomura Toshihiro , Musial Timothy F. , Marshall John J. , Zhu Yiwen , Remmers Christine L. , Xu Jian , Nicholson Daniel A. , Contractor Anis 
Published: October 2017

Fragile X syndrome (FXS) is a neurodevelopmental disorder that is a leading cause of inherited intellectual disability, and the most common known cause of autism spectrum disorder. FXS is broadly characterized by sensory hypersensitivity and several developmental alterations in synaptic and circuit function have been uncovered in the sensory cortex of the mouse model of FXS (Fmr1KO). GABA-mediated neurotransmission and fast-spiking (FS) GABAergic interneurons are central to cortical circuit development in the neonate. Here we demonstrate that there is a delay in the maturation of the intrinsic properties of FS interneurons in the sensory cortex, and a deficit in the formation of excitatory synaptic inputs on to these neurons in neonatalFmr1KO mice. Both these delays in neuronal and synaptic maturation were rectified by chronic administration of a TrkB receptor agonist. These results demonstrate that the maturation of the GABAergic circuit in the sensory cortex is altered during a critical developmental period due in part to a perturbation in BDNF-TrkB signaling, and could contribute to the alterations in cortical development underlying the sensory pathophysiology of FXS.SIGNIFICANCE STATEMENTFragile X (FXS) individuals have a range of sensory related phenotypes, and there is growing evidence of alterations in neuronal circuits in the sensory cortex of the mouse model of FXS (Fmr1KO). GABAergic interneurons are central to the correct formation of circuits during cortical critical periods. Here we demonstrate a delay in the maturation of the properties and synaptic connectivity of interneurons inFmr1KO mice during a critical period of cortical development. The delays both in cellular and synaptic maturation were rectified by administration of a TrkB receptor agonist, suggesting reduced BDNF-TrkB signaling as a contributing factor. These results provide evidence that the function of fast-spiking interneurons is disrupted due to a deficiency in neurotrophin signaling during early development in FXS.
Tumor‐associated macrophages (TAMs) depend on ZEB1 for their cancer‐promoting roles
Authors: Cortés Marlies , Sanchez‐Moral Lidia , de Barrios Oriol , Fernández‐Aceñero María J , Martínez‐Campanario MC , Esteve‐Codina Anna , Darling Douglas S , Győrffy Balázs , Lawrence Toby , Dean Douglas C , Postigo Antonio 
Published: October 2017

AbstractAccumulation of tumor‐associated macrophages (TAMs) associates with malignant progression in cancer. However, the mechanisms that drive the pro‐tumor functions of TAMs are not fully understood. ZEB1 is best known for driving an epithelial‐to‐mesenchymal transition (EMT) in cancer cells to promote tumor progression. However, a role for ZEB1 in macrophages and TAMs has not been studied. Here we describe that TAMs require ZEB1 for their tumor‐promoting and chemotherapy resistance functions in a mouse model of ovarian cancer. Only TAMs that expressed full levels of Zeb1 accelerated tumor growth. Mechanistically, ZEB1 expression in TAMs induced their polarization toward an F4/80low pro‐tumor phenotype, including direct activation of Ccr2. In turn, expression of ZEB1 by TAMs induced Ccl2, Cd74, and a mesenchymal/stem‐like phenotype in cancer cells. In human ovarian carcinomas, TAM infiltration and CCR2 expression correlated with ZEB1 in tumor cells, where along with CCL2 and CD74 determined poorer prognosis. Importantly, ZEB1 in TAMs was a factor of poorer survival in human ovarian carcinomas. These data establish ZEB1 as a key factor in the tumor microenvironment and for maintaining TAMs’ tumor‐promoting functions.
Diseño y validación de contenido de un instrumento para medir la gestión de la seguridad y salud en el trabajo para organizaciones colombianas
Authors: Erazo Imbacuán Gloria María , Rodríguez Rojas Yuber Liliana 
Published: October 2017

<p>En Colombia, ante la gran expectativa y evolución de las normativas emanadas en la Ley 1562 de 2012 y en el Decreto 1072 de 2015, es preciso construir y aplicar indicadores válidos y legitimados, pues los indicadores son la visión compartida de la forma como se logran los fines. Por lo anterior, en esta investigación se diseñó un instrumento para medir la gestión de la seguridad y salud en el trabajo con validez de contenido para organizaciones colombianas, bajo la estructura de alto nivel planteada por la ISO, la cual será la base de la futura norma técnica ISO 45001. A partir de la revisión de la literatura y la consulta a expertos (14 expertos de 6 administradoras de riesgos laborales) se construyó el instrumento, el cual integró y alineó los requerimientos de cumplimiento del Decreto 1072 de 2015 y del draft de la norma técnica ISO 45001, desde el principio de que el instrumento es una herramienta que provee información para la toma de decisiones en materia de prevención y control de riesgos.</p>
Gestión del riesgo como eje articulador de un sistema de gestión integrado en las pymes
Authors: Castañeda Muñoz Martha Lucía , Sánchez Prieto Jairo Alexander 
Published: October 2017

<p>En este artículo se presentan los resultados de una investigación realizada con el fin de reconocer la perspectiva de los auditores y coordinadores de sistemas de gestión sobre la aplicación del modelo de gestión del riesgo ISO 31000 y de aportar un modelo de gestión del riesgo que funcione como eje articulador y facilite la gestión integrada de las normas ISO 9001, ISO 14001 y OHSAS 18001, teniendo en cuenta los cambios futuros que tendrán estas normas. Para ello se realizaron encuestas a 26 auditores o consultores de sistemas de gestión y nueve entrevistas a coordinadores de sistemas de gestión en Pyme. El análisis de estas confirmó que las empresas objeto de estudio no realizan gestión del riesgo, no tienen en cuenta las partes interesadas ni el contexto donde existe la organización.</p><p>La investigación permitió identificar los elementos claves entre los sistemas de gestión ISO 9001, ISO 14001, OHSAS 18001 e ISO 31000, que contribuyen<br />a que la gestión del riesgo se convierta en el eje articulador de estos sistemas de gestión y no en un cuarto sistema de gestión, lo que facilita la gestión<br />integrada. Asimismo, el marco teórico y normativo, y los resultados del trabajo de campo aportaron significativamente a la definición del modelo de gestión<br />del riesgo y su articulación e importancia con las otras normas.</p>
Beneficios e impactos de la implementación de normas técnicas en las organizaciones: una revisión sistemática
Authors: Díaz Romero Constanza Cristina , Rodríguez Rojas Yuber Liliana 
Published: October 2017

<p>Este artículo busca analizar los beneficios e impactos a nivel interno y externo de la implementación de sistemas de gestión normalizados en las organizaciones.<br />Para ello, se realizó una revisión sistemática exploratoria en las bases de datos Business Source Complete, Ebsco, SocINDEX y Proquest, siguiendo la metodología propuesta por Manchado, Tamames, López, Mohedano et al. (2009), de artículos publicados entre 1997 y 2014. El análisis se efectuó desde cinco categorías de beneficios e impactos en la gestión, la imagen, las personas, la productividad y el mercado. Los resultados muestran que, independientemente del sector económico, implementar una norma técnica ISO en la gran mayoría de los casos, mejora los resultados sobre el mercado y la productividad.</p>
Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library
Authors: Jiang Shuangying , Liu Yan , Xu Caiyue , Wang Yun , Gong Jianhui , Shen Yue , Wu Qingyu , Boeke Jef D , Dai Junbiao 
Published: October 2017

Abstract
Using a comprehensive library of histone H2A and H2B mutants, we assessed the biological function of each amino acid residue involved in various stress conditions including exposure to different DNA damage-inducing reagents, different growth temperatures, and other chemicals. H2B N- and H2A C-termini were critical for maintaining nucleosome function and mutations in these regions led to pleiotropic phenotypes. Additionally, two screens were performed using this library, monitoring heterochromatin gene silencing and genome stability, to identify residues that could compromise normal function when mutated. Many distinctive regions within the nucleosome were revealed. Furthermore, we used the barcode sequencing (bar-seq) method to profile the mutant composition of many libraries in one high-throughput sequencing experiment, greatly reducing the labor and increasing the capacity. This study not only demonstrates the applications of the versatile histone library, but also reveals many previously unknown functions of histone H2A and H2B.
Genetic Gain Increases by Applying the Usefulness Criterion with Improved Variance Prediction in Selection of Crosses
Authors: Lehermeier Christina , Teyssèdre Simon , Schön Chris-Carolin 
Published: October 2017

Abstract
A crucial step in plant breeding is the selection and combination of parents to form new crosses. Genome-based prediction guides the selection of high-performing parental lines in many crop breeding programs which ensures a high mean performance of progeny. To warrant maximum selection progress, a new cross should also provide a large progeny variance. The usefulness concept as measure of the gain that can be obtained from a specific cross accounts for variation in progeny variance. Here, it is shown that genetic gain can be considerably increased when crosses are selected based on their genomic usefulness criterion compared to selection based on mean genomic estimated breeding values. An efficient and improved method to predict the genetic variance of a cross based on Markov chain Monte Carlo samples of marker effects from a whole-genome regression model is suggested. In simulations representing selection procedures in crop breeding programs, the performance of this novel approach is compared with existing methods, like selection based on mean genomic estimated breeding values and optimal haploid values. In all cases, higher genetic gain was obtained compared with previously suggested methods. When 1% of progenies per cross were selected, the genetic gain based on the estimated usefulness criterion increased by 0.14 genetic standard deviation compared to a selection based on mean genomic estimated breeding values. Analytical derivations of the progeny genotypic variance-covariance matrix based on parental genotypes and genetic map information make simulations of progeny dispensable, and allow fast implementation in large-scale breeding programs.
Full shift assessment of back and head postures in overhead crane operators with and without symptoms
Authors: Nourollahi-Darabad Maryam , Mazloumi Adel , Saraji Gabraeil Nasl , Afshari Davood , Foroushani Abbas Rahimi 
Published: October 2017

Abstract

Objectives
Prolonged sitting with a flexed back and neck is recognized as being associated with an increased risk of neck and back pain disorders among overhead crane operators. The aim of this study was to compare back and head postures over a full shift of work between operators who experience back and neck pain, and healthy operators.

Methods
In a first phase, the prevalence of musculoskeletal symptoms was assessed using the Nordic questionnaire among 120 crane operators. Based on first phase results, 17 operators with back/neck disorders were matched with 15 healthy operators based on age and selected to participate in the second phase of the study. Postures and movements were continuously measured over an 8 h shift using inclinometers.

Results
The highest 12-month prevalence of musculoskeletal disorders was found in the lower back, neck and knees. Case and control groups differed significantly in back and head flexion angles at the 50th percentiles APDF (p &lt; 0.05). There was also a significant difference in the time spent working in an extreme posture of the back and head between groups (p &lt; 0.05).

Conclusions
This is the first study to document work postures assumed during a full work shift and to compare postures between symptomatic and healthy overhead crane operators. Physical exposure in case group operators was characterized by more awkward and extreme postures in the back and head. The results of this study demonstrate that effective prevention strategies directed towards musculoskeletal disorders are required that address awkward work postures for overhead crane operators.
Populációalapú „pilot” colorectalis rákszűrés eredményessége. Csongrád megye, 2015
Authors: Rutka Mariann , Molnár Tamás , Bor Renáta , Farkas Klaudia , Fábián Anna , Győrfi Márk , Bálint Anita , Milassin Ágnes , Szűcs Mónika , Tiszlavicz László , Nagy Ferenc , Szepes Zoltán 
Published: October 2017

Abstract: Introduction: In Hungary, a nationwide colorectal screening program is about to be introduced in order to improve the extremely high mortality rate of colorectal cancer (CRC). Aim: The aim of our study was to summarize experiences and assess short-term efficacy of the population-based pilot colorectal screening program in 2015 in Csongrád County, Hungary. Patients and method: Asymptomatic individuals between the ages of 50 and 70 with average risk of colorectal cancer participated in the program that was based on the two-step screening method (i.e. immune fecal blood test and colonoscopy). The short-term efficacy of the screening program was assessed as the change in total CRC incidence and initial tumor stage in the screening year (2015) compared to a control year (2013) in Szeged and its surroundings. Participation rate, positive predictive value of the screening methods and tumor detection rate was assessed. Results: 22,130 individuals were invited, the participation rate was 46.4%. Immune fecal blood test proved to be non-negative in 1,343 cases (13%), screening colonoscopy was performed in 766 of them (7.5%). Total colonoscopy was performed in 711 individuals. Based on the reports, adenoma was detected in 358 (50.3%) and malignancy in 42 (5.9%) individuals. In the background population, the incidence of colon cancer was significantly higher (183 vs. 228; p = 0.026) and was diagnosed at significantly earlier stage (p = 0.002). Lymph node involvement was significantly lower in 2015 (48.3% vs. 37.1%; p = 0.049). Conclusion: The Csongrád county population-based colorectal cancer screening was evidently successful on the short term considering participation rate, and the changes in CRC incidence and stage, thus its national extension is necessary. Orv Hetil. 2017; 158(42): 1658–1667.