bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of stress related mucosal damage using intravenous omeprazole
Authors: Sun Tiefeng , Xiao Qing , Gu ChaoFeng , Diao Xiaomin 
Published: September 2024

Purpose: To evaluate the effect of using intravenous injection of omeprazole to prevent stress-related mucosal damage (SRMD) in critically ill patients.
Methods: 80 critically ill patients from the Eighth People's Hospital of Qingdao, Qingdao, China were recruited and randomly divided into control and study groups comprising 40 patients each. Control group received conventional symptomatic treatment comprising nutritional support, acid-base balance regulation, electrolyte level monitoring and correction, maintenance of fluid and electrolyte equilibrium, respiratory function management, and anti-infection measures. Study group received intravenous injection of omeprazole (20 mg/day) and conventional symptomatic treatment for 3 months. Treatment effect, gastric pH, and gastroscopic observation of the two groups of patients were recorded.
Results: The study group demonstrated significantly higher treatment efficacy (97.5 %) compared to control group (80 %, p < 0.05). Pre-treatment gastric pH did not differ significantly between the groups (p > 0.05). After treatment, the study group exhibited significantly higher pH levels (p < 0.05). Normal endoscopic findings increased to 85 % in the study group compared to 20 % in control group (p < 0.05).
Conclusion: Intravenous omeprazole significantly prevents SRMD in critically ill patients, improves gastric pH regulation and reduces abnormal endoscopic findings. Larger-scale, multicenter, and long-term studies are needed to validate the findings of this study.
An overview of polypharmacology: A multifaceted approach to drug development
Authors: Samman Waad A. 
Published: September 2024

The idea of polypharmacology describes the ability of a molecule to interact with two or more targets at once. When compared to traditional single-targeting compounds, it has numerous advantages. Several proteins and pathways are involved in the initiation and progression of complex and multifactorial diseases such as cancer. A chemical must be promiscuous, or able to interact with various targets, to be considered polypharmacologic. It must also be able to avoid attaching to anti-targets, which would cause off-target negative effect. Researchers anticipate whether or not a developed molecule will be promiscuous by looking for specific structural traits and physicochemical qualities. Promiscuity is determined using cutting-edge, modern computational techniques. The "one drug, multiple targets" polypharmacology paradigm has many uses, particularly in drug repurposing which is the process of developing an already-approved medication for novel use. Details on how one might purposefully introduce promiscuity into compounds to make them polypharmacologic are also provided in this review.
Anti-atherogenic effect of <i>Channa striatus</i> fish extract in high cholesterol-fed rabbits
Authors: Hakim Muhammad Nazrul , Yee Pang Chong , Cheema Manraj Singh , Keong Yong Yoke , Ahmad Zuraini 
Published: September 2024

Purpose: To determine the effect of aqueous extract of Channa striatus on plasma lipids concentrations, pro-inflammatory cytokines levels, adhesion molecules and arterial plaque formation in cholesterol-fed rabbits.
Methods: New Zealand rabbits (n = 30, females) were divided into five groups of six rabbits each as follows: cholesterol control group (0.5 % cholesterol); normal control group (normal diet), positive control group (0.5 % cholesterol + 5 mg/kg atorvastatin); and treatment groups (0.5% cholesterol + 250 mg/kg or 500 mg/kg C. striatus extracts, respectively) for 6 weeks. Blood was taken every 2 weeks and analyzed for total cholesterol (TC), low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), triglyceride (TG), tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β). Atherogenic index (AI) was calculated based on LDL:HDL ratio.
Results: Cholesterol feeding for 6 weeks resulted in significantly increased TC, LDL, HDL, AI, TG, TNFα and IL-1β when compared to C. striatus-fed rabbits. Serum LDL was 26.34 ± 1.43 mmol/L in C. striatus group to 30.52 ± 0.82 mmol/L in cholesterol group (p < 0.05). C. striatus extract (250 mg/kg) increased HDL by approximately 400 % (6.23 ± 1.76 mmol/L from 0.72 ± 0.18 mmol/L), decreased AI value (4.6 in C. striatus group to 10.4 in cholesterol group). Also, IL-1β and TNF-α concentration also significantly (p < 0.05) reduced with C. striatus administration. Interestingly, down-regulation of ICAM-1 and VCAM-1 expression and reduced plaque formation were observed with C. striatus feeding.
Conclusion: Channa striatus extract is effective in reducing atherogenesis. This could be due to the high HDL level produced in 250 mg/kg dose group, and strongly suggests the significance of HDL in preventing atherogenesis even if other lipid profiles remain unchanged
Proselytism of the Catholic Clergy in the Western Russian Dioceses of the Russian Empire (on the Example of the Activities of Father Andrei Verzhbitsky)
Authors: Бабак К.С. 
Published: September 2024

Западнорусский регион Российской империи практически во все времена своей истории являлся эпицентром конфессионального противостояния между православием и католицизмом. Это было вызвано политической конфронтацией между Московским и Польским государствами, усугубляемой еще и конфликтами на почве национальной принадлежности. Манифест «Об укреплении начал веротерпимости» от 17 апреля 1905 г. в западнорусском регионе Российской империи с новой силой спровоцировал рост конфессионального и национального противостояний. В статье предпринята попытка осветить прозелитическую деятельность католического духовенства на примере ксёндза Андрея Вержбицкого.
The Western Russian region of the Russian Empire has been, for most of its history, the epicenter of confessional confrontation between Orthodoxy and Catholicism. This was due to the political confrontation between the Moscow and Polish states, exacerbated by conflicts based on national identity. The Manifesto “On the Strengthening of the Principles of Religious Tolerance” of April 17, 1905, in the Western Russian region of the Russian Empire, provoked a resurgence of confessional and national confrontations. This article attempts to shed light on the proselytizing activities of the Catholic clergy using the example of Father Andrei Verzhbitsky.
Issues of reforming secondary spiritual education based on the materials of the Pre-Council presence of 1906
Authors: Пашков В.П. 
Published: September 2024

В данной статье дан реферативно-аналитический обзор содержания протоколов заседаний V отдела Предсоборного присутствия 1906 г., посвященных реформированию системы среднего духовного образования в России. Внимание сосредоточено на духовных семинариях. Ключевые проблемы в системе среднего духовного образования, требовавшие внесения конструктивных изменений, к началу ХХ в. сводились к следующим: преобладание сословности, низкий уровень образованности будущих пастырей Церкви, девальвация духовных ценностей и представлений о благодати священного сана по причине частых случаев вступления на этот путь по принуждению. В ходе обсуждений на заседаниях Предсоборного присутствия были предложены меры по преодолению перечисленных и иных недостатков семинарского образования, которые могли стать конструктивными в случае их реализации. Прежде всего предлагалось впредь разделять общеобразовательный и профессиональный уровни, унифицируя содержание первого с целью предоставления возможности продолжения представителям духовенства обучаться в дальнейшем по программам светских учебных заведений. Результаты этих обсуждений актуальны и в настоящее время, так как духовные семинарии — самый многочисленный тип духовных учебных заведений РПЦ и процессы реформирования в них носят регулярный характер. Предреволюционный опыт в данном отношении может послужить аналоговой базой для принятия некоторых решений, а его анализ расширяет предметное поле церковно-исторической науки.
This research gives a summary and analytical review of the V department Pre-Council Presence of 1906 meetings protocols content, devoted to the reform of the secondary spiritual education system in Russia. Attention is focused on theological seminaries. By the beginning of the 20th century, the key problems in the system of secondary spiritual education, which required constructive changes, were reduced to the following: the predominance of caste, the low level of education of future Church pastors, the devaluation of spiritual values and the grace of holy orders due to frequent cases of entering this path under duress. During the discussions at the meetings of the Pre-Council Presence, measures were proposed to overcome these and other shortcomings of seminar education, which could become constructive if they were implemented. The main thing was that it was proposed to further separate the general education and professional levels, unifying the content of the first in order to allow the clergy to continue studying in the future according to the programs of secular educational institutions. The results are relevant at the present time, because theological seminaries are the most widely represented type of religious educational institutions of the Russian Orthodox Church and the reform processes in them are regular. The prerevolutionary experience in this regard can serve as an analog basis for making some decisions, and its analysis expands the subject field of church historical science.
Monastic “Turmoils” in “Stoglav” and the Message of Ivan IV to the Kirillo-Belozersky Monastery
Authors: Шапошник В.В. 
Published: September 2024

На Стоглавом соборе 1551 г. рассматривались различные вопросы церковной жизни. Уже в первой главе «Стоглава», в которой кратко излагается программа Собора, указывается, среди прочего, что речь пойдет и о «монастырских чинех» — «исправлении» существующих недостатков, в том числе и в жизни монастырей, ярко описанных в некоторых «царских» вопросах. Для исправления ситуации в «Стоглаве» описываются правила монастырской жизни и устанавливаются меры по преодолению замеченных негативных явлений. Вместе с тем, даже спустя два десятилетия, с точки зрения Ивана Грозного, ситуация в ряде русских обителей не улучшилась, как это следует из текста его послания в Кирилло-Белозерский монастырь. Причем все «нестроения» связаны со знатью, с «боярами», которые стремятся разрушить строгие правила монастырской жизни.
At the Stoglav Council in 1551, various issues of church life were considered. And in the first chapter of “Stoglav”, which briefly outlines the program of the Council, it is indicated, among other things, that the focus will also be on “monastic rites” ― “correction” of existing drawbacks, in the life of monasteries as well, which are vividly described in some “tzarist” questions. To correct the situation, “Stoglav” defines the rules of monastic life and establishes the measures to overcome the observed negative phenomena. At the same time, just two decades later, according to Ivan the Terrible, the situation in a number of Russian monasteries did not improve, as it follows from the text of his message to the Kirillo-Belozersky Monastery. Moreover, all the “turmoils” are associated with nobility, with “boyars” who seek to destroy the strict rules of monastic life.
Pengaruh Beban Kerja Dan Kompensasi Terhadap Tingkat Turnover Karyawan Pada PT. Everbright Medan
Authors: Adinda  
Published: September 2024

ABSTRAK

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis pengaruh Beban kerja dan kompensasi terhadap Turnover karyawan pada PT. Everbright Medan. Pendekatan yang digunakan dalam Kompensasi terhadap penelitian ini adalah pendekatan asosiatif. Populasi dalam penelitian ini adalah keseluruhan pegawai divisi administrasi PT. Everbright Medan yang berjumlah 36 orang dan sampel yang digunakan dalam penelitian ini adalah keseluruhan populasi yaitu 36 orang. Teknik pengumpulan data dalam penelitian ini menggunakan angket. Teknik analisis data dalam penelitian ini menggunakan Uji Asumsi Klasik, Regresi Berganda, Uji t dan Uji F, dan Koefisien Determinasi. Pengolahan data dalam penelitian ini menggunakan program software SPSS (versi 25.00). Secara parsial beban kerja memiliki pengaruh negatif dan signifikan terhadap Turnover karyawan pada PT. Everbright Medan. Dan Kompensasi memiliki pengaruh positif dan signifikan terhadap Turnover karyawan pada PT. Everbright Medan. Secara simultan beban kerja dan kompensasi memiliki pengaruh signifikan terhadap Turnover karyawan pada PT. Everbright Medan.
Kata Kunci : Beban Kerja, Kompensasi dan Turnover karyawan.

ABSTRACT

The purpose of this study was to determine and analyze the effect of workload and compensation on employee turnover at PT. Everbright Medan. The approach used in the Compensation of this research is an associative approach. The population in this study were all employees of the administration division of PT. Everbright Medan, totaling 36 people and the sample used in this study was the entire population of 36 people. Data collection techniques in this study used a questionnaire. The data analysis technique in this study uses the Classical Assumption Test, Multiple Regression, t-test and F-test, and the Coefficient of Determination. Data processing in this study using the SPSS software program (version 25.00). Partially the workload has a negative and significant effect on employee turnover at PT. Everbright Medan. And compensation has a positive and significant impact on employee turnover at PT. Everbright Medan. Simultaneously workload and compensation have a significant effect on employee turnover at PT. Everbright Medan.

Keywords: Current Ratio, Debt to Equity Ratio, Debt to Asset Ratio and Return On Asset
Jivha Pariksha – An Ayurvedic Diagnostic tool: A Review
Authors: Sharma Vandana , Yadav Chhaju Ram , Sarika Yadav  
Published: September 2024

Introduction: The tongue is most convenient approach to observe changes in the body's fundamental components and assess the progression of disease. The Ayurvedic Samhita lists several types of Rogi Pariksha that can be used to diagnose the disease. The Ashtavidha Pariksha, is described by Acharya Yogratnakar. Jivha Pariksha is one among them. Jivha Pariksha involves shape, colour, moisture, movement and the coating on the tongue. Jivha pariksha reveals our main constitution (normal prakruti), imbalance of dosha, state of agni (digestive fire) and koshtha (Annavaha strotas). According to Ayurveda Agnimandya (hypo functioning of digestive fire) is the root cause of all diseases. Saam jivha (Coated tongue) indicates a presence of Ama (undigested food) in the digestive system. Thick coating indicates the progression of disease so Jivha Pariksha is very important in diagnosis as well as prognosis of various diseases. Aim – To Study the significance of Jivha Pariksha in diagnostic tools. Objectives – To Study importance of Jivha Pariksha in diagnostic methodology from Ayurveda texts and its application in diagnosing the various kind of diseases. Material and methods – This is a conceptual study for which various Ayurveda and modern text, Samhitas, published articles, research papers and information available on internet is used. Discussion – Jivha pariksha is very important in routine examination of patient as it is a part of Ashtvidha Pariksha. During examination one should have knowledge about the shape, colour, coat of the tongue. For appropriate disease diagnosis and treatment, a proficient understanding of Jivha parikhsha is required. Result – Jivha pariksha is very important tool in Ayurveda for the diagnosis and prognosis of disease. The jiva pariksha is a significant diagnostic and prognostic tool in the medical field.
A Novel Morphological Rule-based Approach for Urdu Text Sentiment Analysis
Authors: Majid Abdul , Naqvi Uzma , Shokat Sana , Azeem Adnan 
Published: September 2024

Sentiment Analysis (SA) is an exciting research area in Urdu text classification tasks. Due to its complicated morphology, sentiment analysis in Urdu poses various challenges. The lexicon-based technique is the preferred approach for Urdu sentiment analysis for its high accuracy rate. This approach requires a comprehensive manual list of positive and negative words. Sentiment classification can be effectively achieved using morphology-driven methods. For this purpose, an effective Urdu sentiment analyser employing morphological rules for performing Urdu sentiment analysis is proposed. The application of the rules depends on the input words' lexical category and prefixes. Sentiment classification rules are proposed based on the prefixes attached to negative sentiment carrier words. A thorough evaluation with reasonable Urdu text document/dataset size is performed. The empirical assessment proved that the proposed rule-based method achieved satisfactory precision, recall, and accuracy.
TÌNH TRẠNG DINH DƯỠNG CỦA BỆNH NHÂN XƠ GAN DO VIÊM GAN B ĐIỀU TRỊ NGOẠI TRÚ TẠI BỆNH VIỆN ĐA KHOA ĐỐNG ĐA NĂM 2023
Authors: Nguyễn Thùy Linh , Lê Mai Trà Mi , Pham Thị Tuyết Chinh , Nguyễn Thu Trang , Nguyễn Thị Mai Hương , Nguyễn Thị Minh Thu 
Published: September 2024

Đặt vấn đề: Suy dinh dưỡng là tình trạng phổ biến ở người bệnh xơ gan. Dinh dưỡng kém sẽ làm tổn thương gan nặng thêm, ảnh hưởng đến chất lượng cuộc sống và thời gian sống sót. Nghiên cứu nhằm mô tả đặc điểm bệnh lý và tình trạng dinh dưỡng của người bệnh xơ gan do viêm gan B. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang thực hiện trên 32 người bệnh xơ gan do viêm gan B điều trị ngoại trú tại bệnh viện đa khoa Đống Đa từ tháng 11/2022 đến tháng 07/2023. Kết quả: Đối tượng nghiên cứu xơ gan Child-pugh A chiếm 84.4%. Theo SGA, 43.7% người bệnh xơ gan có nguy cơ suy dinh dưỡng nhẹ, vừa và nặng. 46.9% đối tượng nghiên cứu ăn dưới 4 bữa/ngày. Người bệnh được phân loại xơ gan Child-pugh B ở nhóm có tình trạng dinh dưỡng tốt là 11.1%, thấp hơn ở nhóm người bệnh có nguy cơ suy dinh dưỡng nhẹ, trung bình và nặng (21.4%). Kết Luận: Tỉ lệ người bệnh có nguy cơ suy dinh dưỡng cao vì vậy việc đánh giá dinh dưỡng và can thiệp dinh dưỡng sớm có vai trò quan trọng trong điều trị cho người bệnh xơ gan.
Getting German Colonialism Right
Authors: Hama Aldric 
Published: September 2024

Aldric Hama looks at Bruce Gilley’s In Defense of German Colonialism: And How its Critics Empowered Nazis, Communists, and the Enemies of the West, writing that Gilley does another fine job of laying out the advantages for those subject to European colonial rule, this time specifically to German colonial rule. Hama sees the need for more research on the largely neglected field of colonialism in the Far East, especially on the role of imperial Japan.
A IMPORTÂNCIA DO ACOMPANHAMENTO FARMACÊUTICO NO PERÍODO GESTACIONAL
Authors: Santos Vitoria Caroline Maia dos , Baiense Alex Sandro Rodrigues , Andrade Leonardo Guimarães de 
Published: September 2024

A utilização indiscriminada de muitos medicamentos faz com que o farmacêutico deva prestar especial atenção ao aparecimento de interações e á evolução de suas possíveis consequências. Isto é especialmente importante em pacientes idosos, em crianças e em mulheres gestantes, sendo estas últimas, o enfoque de grande número de estudo devido sua complexidade. Dessa forma a pesquisa teve como objetivo geral, descrever através de uma revisão bibliográfica, o papel do farmacêutico no acompanhamento e no período gestacional. Já os objetivos específicos foram: Descrever os principais fármacos utilizados na gestação; Destacar e traçar o perfil farmacêutico na atenção à pacientes gestantes; Avaliar a prevalência e fatores associados à utilização de medicamentos durante o período gestacional e a Importância do acompanhamento profissional durante o processo farmacoterapêutico na gestação. Utilizou-se a pesquisa bibliográfica, oriunda de publicações nas Bases de Dados). Podendo assim o farmacêutico clínico prescrever medicamento isenta de prescrição médica com segurança ou encaminhar os pacientes para o médico.
ACCOUNTABILITY NA GESTÃO PÚBLICA: UMA DISCUSSÃO NA GESTÃO DO TURISMO
Authors: Ribeiro Eder Neif Alves , Gomes Douglas Willyam Rodrigues 
Published: September 2024

A accountability na gestão pública é um princípio fundamental que visa garantir que os gestores e autoridades públicas sejam responsáveis e transparentes em relação às suas ações, decisões e administração dos recursos públicos. No contexto específico da gestão do turismo, a accountability desempenha um papel crucial na promoção de práticas de governança que assegurem o uso adequado dos recursos destinados ao desenvolvimento turístico, além de garantir a prestação de contas aos cidadãos e demais stakeholders envolvidos. Este estudo explora como a accountability é aplicada na gestão do turismo, destacando sua importância para mitigar riscos de corrupção, garantir a transparência nas políticas públicas e promover um ambiente favorável ao desenvolvimento sustentável do setor. O artigo apresenta como objetivo geral, discutir a accountability na gestão pública no âmbito do turimo, trazendo as pontecialidades e desafios como a base para a análise. Além disso, discute-se, também, o papel da participação da sociedade civil e dos stakeholders do turismo na accountability, enfatizando como o engajamento ativo desses atores pode contribuir para uma gestão mais eficiente e inclusiva. São apresentados exemplos de boas práticas e desafios enfrentados na implementação de políticas de accountability na gestão do turismo, com ênfase na necessidade de criar estruturas regulatórias sólidas e promover uma cultura organizacional baseada na ética e na transparência. Por fim, o estudo conclui que a accountability na gestão do turismo não só fortalece a confiança pública e a legitimidade das instituições governamentais, mas também é essencial para assegurar que o turismo contribua de forma positiva para o desenvolvimento econômico, social e ambiental das comunidades envolvidas.