bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimized partial freezing protocol enables 10-day storage of rat livers
Authors: Ozgur Ozge Sila , Taggart Mclean , Mojoudi Mohammedreza , Pendexter Casie , Filz von Reiterdank Irina , Kharga Anil , Yeh Heidi , Toner Mehmet , Longchamp Alban , Tessier Shannon N. , Uygun Korkut 
Published: October 2024

AbstractPreserving organs at subzero temperatures with halted metabolic activity holds the potential to prolong preservation and expand the donor organ pool for transplant. Our group recently introduced partial freezing, a novel approach in high-subzero storage at -15 °C, enabling 5-day storage of rodent livers through precise control over ice nucleation and unfrozen fraction. However, increased vascular resistance and tissue edema suggested a need for improvements to extend viable preservation. Here, we describe an optimized partial freezing protocol with key optimizations, including an increased concentration of polyethylene glycol (PEG) to enhance membrane stability while minimizing shear stress during cryoprotectant unloading with an acclimation period and a maintained osmotic balance through an increase in bovine serum albumin (BSA). These approaches ensured the viability during preservation and recovery processes, promoting liver function and ensuring optimal preservation. This was evidenced by increased oxygen consumption, decreased vascular resistance, and edema. Ultimately, we show that using the optimized protocol, livers can be stored for 10 days with comparable vascular resistance and lactate levels to 5 days, outperforming the viability of time-matched static cold stored (SCS) livers as the current gold standard. This study represents a significant advancement in expanding organ availability through prolonged preservation, thereby revolutionizing transplant medicine.
Research on time-division multiplexing for error correction and privacy amplification in post-processing of quantum key distribution
Authors: Chen Lei , Chen Xiao-Ming , Yan Ya-Long 
Published: October 2024

AbstractThe post-processing of quantum key distribution mainly includes error correction and privacy amplification. The error correction algorithms and privacy amplification methods used in the existing quantum key distribution are completely unrelated. Based on the principle of correspondence between error-correcting codes and hash function families, we proposed the idea of time-division multiplexing for error correction and privacy amplification for the first time. That is to say, through the common error correction algorithms and their corresponding hash function families or the common hash function families and their corresponding error-correcting codes, error correction and privacy amplification can be realized by time-division multiplexing with the same set of devices. In addition, we tested the idea from the perspective of error correction and privacy amplification, respectively. The analysis results show that the existing error correction algorithms and their corresponding hash function families or the common privacy amplification methods and their corresponding error-correcting codes cannot realize time-division multiplexing for error correction and privacy amplification temporarily. However, according to the principle of correspondence between error-correcting codes and hash function families, the idea of time-division multiplexing is possible. Moreover, the research on time-division multiplexing for error correction and privacy amplification has some practical significance. Once the idea of time-division multiplexing is realized, it will further reduce the calculation and storage cost of the post-processing process, reduce the deployment cost of quantum key distribution, and help to remote the practical engineering of quantum key distribution.
The need for high-resolution gut microbiome characterization to design efficient strategies for sustainable aquaculture production
Authors: Gupta Shashank , Vera-Ponce de León Arturo , Kodama Miyako , Hoetzinger Matthias , Clausen Cecilie G. , Pless Louisa , Verissimo Ana R. A. , Stengel Bruno , Calabuig Virginia , Kvingedal Renate , Skugor Stanko , Westereng Bjørge , Harvey Thomas Nelson , Nordborg Anna , Bertilsson Stefan , Limborg Morten T. , Mørkøre Turid , Sandve Simen R. , Pope Phillip B. , Hvidsten Torgeir R. , La Rosa Sabina Leanti 
Published: October 2024

AbstractMicrobiome-directed dietary interventions such as microbiota-directed fibers (MDFs) have a proven track record in eliciting responses in beneficial gut microbes and are increasingly being promoted as an effective strategy to improve animal production systems. Here we used initial metataxonomic data on fish gut microbiomes as well as a wealth of a priori mammalian microbiome knowledge on α-mannooligosaccharides (MOS) and β-mannan-derived MDFs to study effects of such feed supplements in Atlantic salmon (Salmo salar) and their impact on its gut microbiome composition and functionalities. Our multi-omic analysis revealed that the investigated MDFs (two α-mannans and an acetylated β-galactoglucomannan), at a dose of 0.2% in the diet, had negligible effects on both host gene expression, and gut microbiome structure and function under the studied conditions. While a subsequent trial using a higher (4%) dietary inclusion of β-mannan significantly shifted the gut microbiome composition, there were still no biologically relevant effects on salmon metabolism and physiology. Only a single Burkholderia-Caballeronia-Paraburkholderia (BCP) population demonstrated consistent and significant abundance shifts across both feeding trials, although with no evidence of β-mannan utilization capabilities or changes in gene transcripts for producing metabolites beneficial to the host. In light of these findings, we revisited our omics data to predict and outline previously unreported and potentially beneficial endogenous lactic acid bacteria that should be targeted with future, conceivably more suitable, MDF strategies for salmon.
An open-source approach for measuring corporate impacts on ecosystem services and biodiversity
Authors: Mandle Lisa , Shea Andrew , Soth Emily , Goldstein Jesse A. , Wolny Stacie , Smith Jeffrey R. , Chaplin-Kramer Rebecca , Sharp Richard P. , Patel Mayur 
Published: October 2024

AbstractExisting approaches to evaluating companies on sustainability-related issues include limited accounting of impacts on nature and its contributions to human well-being. Here we present an approach for quantifying the direct impacts of companies’ physical assets on nature based on global maps for eight ecosystem service and biodiversity metrics. We apply this approach to a set of over 2000 global, publicly traded companies with 580,000 mapped physical assets and find that companies in utility, real estate, materials, and financial sectors have the largest impacts on average, with substantial variation within all sectors. Using high-spatial-resolution satellite imagery to map individual mine footprints, we compare a set of active lithium mines and find that impacts vary substantially among mines and change over time. By using open-source models and drawing on the growing availability of high-spatial-resolution satellite imagery, this approach could provide more transparent measures of corporate impacts to nature for nature-related reporting.
Moisture dynamics during high‐load fluctuations in transformers: Localised accumulation and interfacial transfer within oil/pressboard insulation
Authors: Wang Shaoqi , Zhang Qiaogen , Guo Chong , Sun Yuhan , Wu Zhicheng 
Published: October 2024

AbstractPower systems grapple with the challenges of high load rates and intermittent new energy sources integration. Transformers, as vital equipment, employ oil/pressboard (oil/PB) insulation. Uneven moisture distribution in this insulation can jeopardise safety thresholds, necessitating precise moisture assessment for grid stability. A novel mathematical model, adsorption–desorption and porous media moisture transfer (ADP‐MoT), is presented. This model incorporates adsorption and desorption processes within the porous pressboard, enabling a description of the dynamic moisture transfer between the oil and pressboard. Using this mathematical model, simulations for moisture dynamics were performed on a 750‐kV transformer across four typical days. The results indicate that temperature fluctuations are the primary driving factor for moisture migration at the oil/PB interface. Convection and diffusion contribute to moisture movement towards cooler regions. Fluid properties and structural characteristics induce a distinctive streamline‐shaped moisture flow within horizontal oil channels, with localised moisture accumulation in specific areas. Moreover, the analysis of 96 transient results uncovers potential free‐state moisture formation during severe conditions, underscoring the importance of monitoring the pressboard at winding bases during high load fluctuations. In conclusion, this study significantly contributes to scientifically identifying and addressing risks tied to new energy sources integration in power systems.
Intelligent parking lot power management: Augmented epsilon‐constraint concept with correlation analysis
Authors: Nosratabadi Seyyed Mostafa , Peivand Ali , Saadat Amin 
Published: October 2024

AbstractThis paper addresses essential aspects of decision‐making and management in energy resources. To achieve this, a tri‐objective model is proposed that seeks to find the best solution within the basic constraints framework of the optimization problem so that all three proposed objective functions can approach their ideal point. The uncertainty is used for the photovoltaic and wind power plants’ output in the proposed multi‐objective optimization problem as a scenario‐based stochastic approach. The proposed objective functions are realizing the operating cost, the amount of emission produced by generation resources, the amount of load‐shedding, and the maximum participation of responsive demands in the management program. The idea of employing plug‐in electric vehicle (PHEV) units in the form of intelligent parking lots within the network is also included in the proposed study, which can increase network flexibility and help improve the main features of the network. A modified IEEE 83‐bus test system is used to ensure the accuracy and effectiveness of the proposed model. The properties of PHEVs significantly affect the simulation results and compensate for the uncertainty associated with renewable energy sources. Randomly considering the parameters of PHEVs can also realistically bring the results of power management more realistic. In addition, the multi‐objective problem defined for each scenario is solved by the augmented epsilon‐constraint method with the correlation coefficient concept for the network under study, and the Pareto front curves are obtained separately and the best solution is extracted by a proper decision‐making method.
Infrared spectra of solid-state ethanolamine: Laboratory data in support of JWST observations
Authors: Suhasaria T. , Wee S. M. , Basalgète R. , Krasnokutski S. A. , Jäger C. , Perotti G. , Henning Th. 
Published: October 2024

Context. Ethanolamine (NH2CH2CH2OH; EA) has been identified in the gas phase of the interstellar medium within molecular clouds. Although EA has not been directly observed in the molecular ice phase, a solid-state formation mechanism has been proposed. However, the current literature lacks an estimation of the infrared band strengths of EA ices, which are crucial data for quantifying potential astronomical observations and laboratory findings related to their formation or destruction via energetic processing.
Aims. We conducted an experimental investigation of solid EA ice at low temperatures to ascertain its infrared band strengths, phase transition temperature, and multilayer binding energy. Since the refractive index and the density of EA ice are unknown, the commonly used laser interferometry method was not applied. Infrared band strengths were determined using three distinct methods. In addition to evaluating EA band strengths, we also tested the advantages and disadvantages of different approaches used for this purpose. The obtained lab spectrum of EA was compared with the publicly available MIRI MRS James Webb Space Telescope observations towards a low-mass protostar.
Methods. We used a combination of Fourier-transform transmission infrared spectroscopy and quadrupole mass spectrometry.
Results. The phase transition temperature for EA ice falls within the range of 175 to 185 K. Among the discussed methods, the simple pressure gauge method provides a reasonable estimate of band strength. We derived a band strength value of about 1 × 10−17 cm molecule−1 for the NH2 bending mode in the EA molecules. Additionally, temperature-programmed desorption analysis yielded a multilayer desorption energy of 0.61±0.01 eV. By comparing the laboratory data documented in this study with the JWST spectrum of the low-mass protostar IRAS 2A, an upper-limit for the EA ice abundances was derived.
Conclusions. This study addresses the lack of quantitative infrared measurements of EA at low temperatures, crucial for understanding EA’s astronomical and laboratory presence and formation routes. Our approach presents a simple yet effective method for determining the infrared band strengths of molecules with a reasonable level of accuracy.
La correction de mutations pathogènes par Prime editing
Authors: Bouchard Camille , Godbout Kelly , Tremblay Jacques P. 
Published: October 2024

L’édition de gènes est un domaine en évolution constante, le Prime editing étant l’une des techniques les plus récentes. Elle permet de modifier un gène sur mesure à l’aide d’une nickase Cas9 qui ne coupe qu’un seul brin d’ADN. Cette nickase est fusionnée à une transcriptase inverse qui recopie en ADN un ARN guide synthétisé à façon. Cette technique est utilisée pour créer des mutations précises dans des modèles cellulaires ou animaux. Le Prime editing est également appliqué en recherche clinique pour traiter des maladies héréditaires, en corrigeant une mutation responsable de l’effet pathogène. Un défi restant est celui de « livrer » un complexe moléculaire thérapeutique aux cellules in vivo. Différentes méthodes sont élaborées pour atteindre les organes propres à chaque maladie.
Pour une perspective critique et interdisciplinaire de l’écomodernisation des gares. Retour sur le colloque « La nouvelle nature des gares »
Authors: Baron Nacima , Le Bot Nils , Detavernier Pauline 
Published: October 2024

Depuis peu, avec le slogan de gare post-carbone, les métiers de la conception et de la réhabilitation ferroviaire diffusent un cadre d’analyse théorique et pratique en faveur de l’approche écosystémique et métabolique de ces bâtiments. Les contenus et visées de ce mouvement qui cherche à renouveler et étendre l’écologie ferroviaire ont fait l’objet d’un colloque en juillet 2022. Nous explicitons comment nous avons retravaillé le cadre d’analyse pour que les communications et débats dépassent une démarche fonctionnaliste d’« infrastructuration » de la nature au profit de performances (écologie, énergie, transport). Deux résultats ressortent : 1) un cadre typologique des articulations entre les gares et les espaces et objets rapportés à la nature ; 2) une discussion sur les conditions à travers lesquelles la gare peut devenir un objet-frontière transdisciplinaire efficace pour articuler des perspectives naturalistes, techniques, urbaines et sociopolitiques.
Übersetzung des Osteoporosis Knowledge Assessment Tools (OKAT) und
Evaluierung der deutschen Version des OKATs
Authors: Möckel Luis , Kagerer Romina , Kretschmer Rainer 
Published: October 2024

Zusammenfassung
Einleitung Um bei Patient*innen den Wissensstand zur Osteoporose
abzufragen, ist ein validiertes Erhebungsinstrument zwingend notwendig. Aufgrund
des Fehlens eines deutschsprachigen Instruments wurde der aus 20 Items
bestehende, englischsprachige Osteoporosis Knowledge Assessment Test (OKAT)
strukturiert ins Deutsche übersetzt und für die deutsche Sprache bewertet.
Methoden Die Übersetzung des OKATs erfolgte im Forward-Backward-Verfahren.
Im Anschluss erfolgte die Bewertung des deutschen OKATs mit Hilfe einer
Test-Retest-Gruppe sowie einer Pilotgruppe unter anderem unter Berechnung des
Schwierigkeitsindex (prozentualer Anteil korrekter Antworten pro Item),
Cronbachʼs α, McDonalds ω und Pearsonʼs r.
Ergebnisse Es nahmen 22 Personen in der Test-Retest-Gruppe (6 davon im
Alter von 50+Jahre) und 265 Personen an der Pilotgruppe (41,89% im Alter von
50+Jahre) teil. Die deutsche Version des OKATs zeigte ein Cronbachʼs α von 0,79
(95% Konfidenzintervall [95% KI]: 0,75; 0,82) in der Pilotgruppe und ein
McDonalds ω von ebenfalls 0,79 (95% KI: 0,76; 0,83). Cronbachʼs α war in der
Test-Retest-Gruppe sowohl in der Test- (0,83 [95% KI: 0,70; 0,92]) als auch in
der Retest-Runde (0,86 [0,75; 0,93]) vergleichbar. Die Test-Retest-Reliabilität
der deutschen Version des OKATs war mit Pearsonʼs r von 0,87 (95% KI:
0,71; 0,95) als hoch einzuschätzen. Der Schwierigkeitsindex je Item lag mit
Ausnahmen von einem Item sowohl für die Test-Rest- als auch für die Pilotgruppe
bei Werten von 0,06 bis 0,66.
Schlussfolgerung Die deutsche Version des OKATs zeigt für die interne
Konsistenz, die Schwierigkeit und die Test-Retest-Reliabilität
zufriedenstellende Werte und könnte somit als Instrument zur Erfassung des
Osteoporosewissens in Deutschland eingesetzt werden.
The Impact of Adenotonsillectomy on the Quality of Life of Children with Obstructive Sleep Apnea
Authors: Sukumaran Geethi Krishna , Sunanda Asha Chellappan , George Shajul 
Published: October 2024

Abstract
Introduction In children, obstructive sleep apnea (OSA) is a sleep-related breathing disorder that is caused by adenotonsillar hypertrophy and is characterized by upper airway obstruction disturbing sleep.
Objective We conducted this study to evaluate health-related quality of life (QoL) in children with OSA before and after adenotonsillectomy.
Methods A descriptive, observational study was conducted among 43 children in the 4-to-12 years old age group who had symptoms of OSA due to adenotonsillar hypertrophy and who underwent adenotonsillectomy at a tertiary care center during the period from February 2020 to February 2021. The QoL was assessed using the OSA-18 questionnaire preoperatively and at 2 and 6 months postoperatively.
Results Among the study population, males (72)%) were more affected with OSA, with a male-to-female ratio of 2.6:1. Based on the OSA-18 questionnaire assessment, the most severe and frequently observed symptoms were in the domains of sleep disturbance and physical symptoms, in which the mean score was 77 preoperatively. After adenotonsillectomy, the mean OSA-18 score decreased to 28.605 and 22.465 at 2 and 6 months, respectively. At 2 months postsurgery, more significant improvement was noticed in sleep disturbances, physical symptoms, and parent's concern while at 6 months postsurgery, all domains showed equal improvement. Therefore, following adenotonsillectomy, the QoL improved significantly.
Conclusion Obstructive sleep apnea can adversely affect sleep quality as well as neurocognitive and cardiovascular functions. Adenotonsillectomy resulted in significant improvement in the QoL.
Do Anatomical Variations of Sphenoid Sinus Influence Sella Exposure and Residual Disease in Pituitary Surgery? — A Study in an Indian Population
Authors: Gopalakrishnan Aparna , Ganesan Sivaraman , Ramesh Andi Sadayandi , Ramesh Ananthakrishnan , Penubarathi Lokesh Kumar , Raja Kalaiarasi , Lakshmanan Jijitha , Khushwaha Akshat , Kaushal Koshika , Alexander Arun 
Published: October 2024

Abstract
Introduction Endoscopic transsphenoidal surgery (ETS) is the standard practice in pituitary surgeries. The sellar exposure becomes the main factor which determines the residual disease in ETS. Not many studies can be found in the literature on the influence of anatomical variations of the sphenoid on intraoperative sella exposure.
Objective The aim of the current study is to ascertain whether sphenoid sinus variations play a role in sellar exposure and residual tumor volume.
Methods This is a prospective study conducted in a south Indian tertiary care center between June 2020 to June 2022, with 21 study participants who were scheduled to have ETS. The relation of preoperative computed tomography (CT) and magnetic resonance imaging (MRI) parameters with the intraoperative area of sellar exposure and residual tumor volume was evaluated.
Results Sphenoid sinus dimensions, like presellar width (mean = 1.89 ± 0.51 cm), maximum width (mean = 2.94 ± 1.09 cm), presellar depth (mean = 1.14 ± 0.55 cm), suprasellar depth (mean = 1.08 ± 0.24 cm), infrasellar depth (mean = 2.36 ± 0.92 cm), presellar height (mean = 2.22 ± 0.47 cm), or the 9 internal carotid artery (ICA)-related measures, did not have any correlation with the mean intraoperative area of sellar exposure (0.57 ± 0.28 cm2). Also, the adequacy of sellar exposure did not relate to the residual tumor. Preoperative tumor volume was found to be higher (20.2 [55.3–13.2] cm3) in patients with residual tumor compared with those with no residual tumor (5.9 [6.8–5.2] cm3). Tumor extension had a significant association with the residual tumor volume.
Conclusion According to the present study, anatomical variations of the sphenoid sinus do not influence the adequacy of sellar exposure. Further studies need to be undertaken concerning residual tumor volume as well as preoperative tumor volume and extension.
Medications to Modify Aspiration Risk: Those That Add to Risk and Those That May Reduce Risk
Authors: Gonçalves-Pereira João , Mergulhão Paulo , Froes Filipe 
Published: October 2024

AbstractAspiration pneumonia results from the abnormal entry of fluids into the respiratory tract. We present a review of drugs known to affect the risk of aspiration. Drugs that increase the risk of aspiration pneumonia can be broadly divided into those that affect protective reflexes (like cough and swallowing) due to direct or indirect mechanisms, and drugs that facilitate gastric dysbiosis or affect esophageal and intestinal motility. Chief among the first group are benzodiazepines and antipsychotics, while proton pump inhibitors are the most well-studied in the latter group. Pill esophagitis may also exacerbate swallowing dysfunction. On the other hand, some research has also focused on pharmaceutical modulation of the risk of aspiration pneumonia. Angiotensin-converting enzyme inhibitors have been demonstrated to be associated with a decrease in the hazard of aspiration pneumonia in high-risk patients of Chinese or Japanese origin. Drugs like amantadine, nicergoline, or folic acid have shown some promising results in stroke patients, although the available evidence is thus far not enough to allow for any meaningful conclusions. Importantly, antimicrobial prophylaxis has been proven to be ineffective. Focusing on modifiable risk factors for aspiration pneumonia is relevant since this may help to reduce the incidence of this often severe problem. Among these, several commonly used drug classes have been shown to increase the risk of aspiration pneumonia. These drugs should be withheld in the high-risk population whenever possible, alongside general measures, such as the semirecumbent position during sleep and feeding.