bluuebunny/crossref_metadata_2025_split huggingface dataset:
Freud's Metapsychology and the Culture of Philosophy
Authors: Zwicky Jan 
Published: December 2015

I don't believe in any interpretation of dreams. I don't want to believe in dream interpretation. I will not touch this last freedom.— Elias Canetti, The Secret Heart of the ClockTo begin, what I hope will be a surprise: in what follows, I will not be talking (much) about sex and its societal vicissitudes. A surprise because the linkage of Freud's name with the theme ‘civilization and oppression’ will immediately suggest to many a discussion of Freud's theories in Civilization and Its Discontents. It is there that Freud famously argues that civilization, necessary for security in the fulfilment of basic sexual instincts, is made possible only by the restriction of expression of those very same instincts. Worse, the erotic impulse that drives individuals together into community can achieve this limited (“aim-inhibited” — i.e., anti-incestuous, monandrous, monogamous, heterosexual, family-oriented) satisfaction only if the other set of basic human instincts — toward aggression — is also severely inhibited. Civilization's frustration of sexuality is experienced in individuals as neurosis, and its repression of instinctual aggression is achieved by turning the instinct inward, back on its source, in the form of guilt, anxiety, an excoriating conscience, a punishing super-ego.
Flavobacterium psychrophilum Infections in Salmonid Broodstock and Hatchery-Propagated Stocks of the Great Lakes Basin
Authors: Van Vliet Danielle , Loch Thomas P. , Faisal Mohamed 
Published: December 2015

Abstract
Bacterial coldwater disease (BCWD), caused by Flavobacterium psychrophilum, threatens wild and propagated salmonids worldwide and leads to substantial economic losses. In addition to being horizontally transmitted, F. psychrophilum can be passed from infected parents to their progeny, furthering the negative impacts of this pathogen. In Michigan, both feral and captive salmonid broodstocks are the gamete sources used in fishery propagation efforts. A 5-year study was initiated to follow the prevalence of systemic F. psychrophilum infections in feral broodstocks of four species (steelhead Oncorhynchus mykiss [potadromous Rainbow Trout]; Coho Salmon O. kisutch; Chinook Salmon O. tshawytscha; and Atlantic Salmon Salmo salar) residing in three Great Lakes watersheds. Additionally, captive broodstocks of four species (Rainbow Trout, Brown Trout Salmo trutta, Lake Trout Salvelinus namaycush, and Brook Trout Salvelinus fontinalis) maintained at two facilities were assessed for the presence of F. psychrophilum. The resultant offspring from each broodstock population were sampled for F. psychrophilum infections multiple times throughout hatchery residency. Using selective flavobacterial culture and PCR confirmation, F. psychrophilum was detected in all broodstocks except the captive Lake Trout and Brook Trout. Logistic regression analysis demonstrated that among the infected feral broodstocks, Chinook Salmon from the Lake Michigan watershed had the highest prevalence of systemic F. psychrophilum infection (mean = 63.2%). Among the captive broodstocks, the Gilchrist Creek strain of Brown Trout had the highest infection prevalence (mean = 5%). Collectively, the captive broodstocks were found to have significantly lower infection prevalence than the feral broodstocks. Despite the high prevalence of systemic F. psychrophilum infections in many broodstock populations, the bacterium was rarely detected in their progeny during hatchery rearing. However, heavy losses associated with clinical BCWD outbreaks did occur. Collectively, our results reinforce that BCWD continues to threaten Great Lakes basin salmonids.
Received April 6, 2015; accepted August 25, 2015
Spongiosis Hepatis in a Wild Aquarium-Maintained Red Irish Lord
Authors: Hyatt Michael W. , Rosas-Rosas Arely G. , Wolf Jeffrey C. , Frasca Salvatore 
Published: December 2015

Abstract
An aquarium-maintained female Red Irish Lord Hemilepidotus hemilepidotus presented with severe coelomic distension. The fish was anesthetized for ultrasonographic examination, which highlighted multiple cyst-like lesions in the liver and a distended ovary that was filled with follicles and an inspissated egg mass. Multiple exploratory celiotomies were performed for egg mass removal, liver biopsy, ovariosalpingectomy, and body wall rupture repair. Fourteen weeks after original presentation, and subsequent to 2 weeks of anorexia, the fish died. At necropsy, the liver was severely enlarged and distorted by multiple, coalescing, cyst-like spaces with no grossly normal liver parenchyma. The spleen also contained a raised cyst-like structure. Microscopically, the liver had well-demarcated foci of hepatocyte loss with retained meshworks of interconnected, perisinusoidal stellate cells. The fluid-filled spaces surrounded by stellate cells were not lined by epithelium or endothelium. The spleen had similar fluid-filled spaces formed of stellate cells. The cyst-like lesions in the liver were consistent with spongiosis hepatis; however, the concurrent development of a morphologically comparable lesion in the spleen is not typical of spongiosis hepatis cases. This case may represent the first report of spontaneously occurring spongiosis hepatis in a fish maintained in a public aquarium, as well as the first report in a fish of spongiosis hepatis-like lesions in an organ other than the liver.
Received May 19, 2015; accepted September 3, 2015
An integrative somatic mutation analysis to identify pathways linked with survival outcomes across 19 cancer types
Authors: Park Sunho , Kim Seung-Jun , Yu Donghyeon , Peña-Llopis Samuel , Gao Jianjiong , Park Jin Suk , Chen Beibei , Norris Jessie , Wang Xinlei , Chen Min , Kim Minsoo , Yong Jeongsik , Wardak Zabi , Choe Kevin , Story Michael , Starr Timothy , Cheong Jae-Ho , Hwang Tae Hyun 
Published: December 2015

Abstract
Motivation: Identification of altered pathways that are clinically relevant across human cancers is a key challenge in cancer genomics. Precise identification and understanding of these altered pathways may provide novel insights into patient stratification, therapeutic strategies and the development of new drugs. However, a challenge remains in accurately identifying pathways altered by somatic mutations across human cancers, due to the diverse mutation spectrum. We developed an innovative approach to integrate somatic mutation data with gene networks and pathways, in order to identify pathways altered by somatic mutations across cancers.
Results: We applied our approach to The Cancer Genome Atlas (TCGA) dataset of somatic mutations in 4790 cancer patients with 19 different types of tumors. Our analysis identified cancer-type-specific altered pathways enriched with known cancer-relevant genes and targets of currently available drugs. To investigate the clinical significance of these altered pathways, we performed consensus clustering for patient stratification using member genes in the altered pathways coupled with gene expression datasets from 4870 patients from TCGA, and multiple independent cohorts confirmed that the altered pathways could be used to stratify patients into subgroups with significantly different clinical outcomes. Of particular significance, certain patient subpopulations with poor prognosis were identified because they had specific altered pathways for which there are available targeted therapies. These findings could be used to tailor and intensify therapy in these patients, for whom current therapy is suboptimal.
Availability and implementation: The code is available at: http://www.taehyunlab.org.
Contact: jhcheong@yuhs.ac or taehyun.hwang@utsouthwestern.edu or taehyun.cs@gmail.com
Supplementary information: Supplementary data are available at Bioinformatics online.
qsubsec: a lightweight template system for defining sun grid engine workflows
Authors: Droop Alastair P. 
Published: December 2015

Abstract
Summary: The Sun Grid Engine (SGE) high-performance computing batch queueing system is commonly used in bioinformatics analysis. Creating re-usable scripts for the SGE is a common challenge. The qsubsec template language and interpreter described here allow researchers to easily create generic template definitions that encapsulate a particular computational job, effectively separating the process logic from the specific run details. At submission time, the generic template is filled in with specific values. This system provides an intermediate level between simple scripting and complete workflow management tools.
Availability and implementation: Qsubsec is open-source and is available at https://github.com/alastair-droop/qsubsec.
Contact: a.p.droop@leeds.ac.uk
Supplementary information: Supplementary data are available at Bioinformatics online.
rcellminer: exploring molecular profiles and drug response of the NCI-60 cell lines in R
Authors: Luna Augustin , Rajapakse Vinodh N. , Sousa Fabricio G. , Gao Jianjiong , Schultz Nikolaus , Varma Sudhir , Reinhold William , Sander Chris , Pommier Yves 
Published: December 2015

Abstract
Purpose: The rcellminer R package provides a wide range of functionality to help R users access and explore molecular profiling and drug response data for the NCI-60. The package enables flexible programmatic access to CellMiner’s unparalleled breadth of NCI-60 data, including gene and protein expression, copy number, whole exome mutations, as well as activity data for ∼21K compounds, with information on their structure, mechanism of action and repeat screens. Functions are available to easily visualize compound structures, activity patterns and molecular feature profiles. Additionally, embedded R Shiny applications allow interactive data exploration.
Availability and implementation: rcellminer is compatible with R 3.2 and above on Windows, Mac OS X and Linux. The package, documentation, tutorials and Shiny-based applications are available through Bioconductor (http://www.bioconductor.org/packages/rcellminer); ongoing updates will occur according to the Bioconductor release schedule with new CellMiner data. The package is free and open-source (LGPL 3).
Contact: lunaa@cbio.mskcc.org or vinodh.rajapakse@nih.gov
Real-time infrasonic monitoring of the eruption at a remote island volcano using seismoacoustic cross correlation
Authors: Nishida Kiwamu , Ichihara Mie 
Published: December 2015

Abstract
On 2013 November 20, a submarine eruption started close to Nishinoshima island, which lies ∼1000 km south of Tokyo. Real-time monitoring of the eruption is crucial for understanding the formation processes of the new volcano island and related disaster prevention. In situ monitoring, however, is difficult in practice because the closest inhabited island, Chichijima, is 130 km away from Nishinoshima. This study presents an infrasonic monitoring method that uses cross-correlating records at a pair of online stations on Chichijima. One is the horizontal ground velocity recorded at a permanent seismic station operated by the Japan Meteorological Agency (JMA). The seismic records were corrected for atmospheric pressure using an empirical ground response to infrasound. The other is the air pressure recorded at the JMA Meteorological Observatory. For each station, we divided the whole records into 3600-s segments. To suppress outliers, each segment was normalized by the envelope function. We then calculated cross-correlation functions between the pair of stations using the fast Fourier transform. They present clear successive arrivals of infrasound coming from Nishinoshima. We also conducted an offline tripartite-array observation using three low-frequency microphones with a station spacing of ∼50 m installed in 2013 May. The array analysis supports the results obtained from the online stations. The typical root-mean-squared amplitude is on the order of 0.01 Pa, and the typical duration is several days. The amplitudes were primarily controlled by the effective sound velocity structure from Nishinoshima to Chichijima. The infrasonic observations together with the meteorological observation at Chichijima suggest that infrasonic activity was not present in the first two weeks in 2015 January. With the help of a more quantitative estimation of the meteorological effect, we could infer eruptive activity in real time. Now many online seismic stations are available worldwide. This study shows that installation of another infrasonic sensor close to the existing seismic station (∼1 km) is useful for monitoring a remote island volcano in real time.
Design simplicity influences patient portal use: the role of aesthetic evaluations for technology acceptance
Authors: Lazard Allison J , Watkins Ivan , Mackert Michael S , Xie Bo , Stephens Keri K , Shalev Heidi 
Published: December 2015

Abstract
Objective This study focused on patient portal use and investigated whether aesthetic evaluations of patient portals function are antecedent variables to variables in the Technology Acceptance Model.
Methods A cross-sectional survey of current patient portals users ( N  = 333) was conducted online. Participants completed the Visual Aesthetics of Website Inventory, along with items measuring perceived ease of use (PEU), perceived usefulness (PU), and behavioral intentions (BIs) to use the patient portal.
Results The hypothesized model accounted for 29% of the variance in BIs to use the portal, 46% of the variance in the PU of the portal, and 29% of the variance in the portal’s PEU. Additionally, one dimension of the aesthetic evaluations functions as a predictor in the model – simplicity evaluations had a significant positive effect on PEU.
Conclusion This study provides evidence that aesthetic evaluations – specifically regarding simplicity – function as a significant antecedent variable to patients’ use of patient portals and should influence patient portal design strategies.
Jacques Lacan
Authors: Johnston Adrian 
Published: December 2015

Jacques Marie Émile Lacan (b. 13 April 1901–d. 9 September 1981) arguably is the most creative and influential figure in the history of psychoanalysis after Sigmund Freud. Lacan portrays himself as an embattled defender of Freud’s true legacy within and beyond analytic circles, the lone champion of a “return to Freud.” His teachings emphasize the crucial differences between the Freudian unconscious and speciously similar notions such as that of the id as a dark, seething cauldron of irrational, animalistic instincts. He stresses especially the centrality of language in psychoanalysis, with the unconscious subject at stake in analysis being constituted and sustained through socio-symbolic mediations (as per Lacan’s famous thesis according to which “the unconscious is structured like a language”). Dubbed “the French Freud,” Lacan significantly broadened and deepened Freudianism through putting Freud’s discoveries into conversation with a wide range of other disciplines and orientations. In particular, Lacan’s reflections draw frequently and extensively on the resources of 19th- and 20th-century Continental philosophical currents such as German idealism, structuralism, semiotics, phenomenology, and existentialism. Indeed, not only did Lacan inspire the formation of distinctly Lacanian clinical approaches—perhaps his greatest worldwide impact has been (and continues to be) in the fields of the theoretical humanities, themselves heavily indebted to the past two centuries of European philosophy. Over the course of recent decades, Lacan’s concepts/theories of, for instance, the mirror stage, subjectivity, language, desire, drive, jouissance, fantasy, and the objet petit a all have come to serve as key components in numerous scholars’ explorations of issues and instances relating to philosophy, art, literature, cinema, culture, politics, and religion, among other areas of concern. Furthermore, like Freud, Lacan remains a source of heated controversy among various commentators and critics right up through the present day.
France in the 17th Century
Authors: Dee Darryl 
Published: December 2015

The 17th century occupies a pivotal place in the history of France between the turbulence of the Wars of Religion and the long calm of the Old Regime. On the one hand, it was a period of political, economic, religious, and social crises. On the other hand, it was the “Great Century” (Grand Siècle) that saw the establishment of France’s hegemony in Europe, its expansion overseas, the efflorescence of French classical culture, and the zenith of the absolute monarchy. After Henri IV (r. 1589–1610) ended the great religious civil wars, Cardinal Richelieu, prime minister to Louis XIII (r. 1610–1643), embarked on a policy of strengthening royal authority. In 1635, he committed France into the conflagration of the Thirty Years’ War and a quarter-century-long duel with Spain. France emerged from these wars as Europe’s dominant power. Yet the cost was high. The monarchy’s efforts to increase its authority and to raise the money it needed to pay its armies provoked massive resistance from all levels of French society. There were 232 popular uprisings between 1635 and 1660. Elite opposition to the crown culminated the Fronde, a near-revolution against Richelieu’s successor, Cardinal Mazarin. After assuming personal rule in 1661, Louis XIV (r. 1643–1715) determined to complete the work begun by his predecessors. He reformed the state, secured the obedience of the French elites, expanded his army to the largest in Europe, and encouraged the growth of colonies abroad. He established a glittering court at Versailles and promoted the development of the arts. The Sun King became a model other European rulers strove to emulate. After 1688, however, Louis XIV’s bellicose foreign policy led to a new round of wars that would darken the end of the century. This entry aims to introduce students and researchers to the historical scholarship on this fascinating period. It begins after the reign of Henri IV. For information on France under the first Bourbon monarch, see the entries on the Reformation and Wars of Religion in France and Henri IV.
Mack Sennett
Authors: D'haeyere Hilde 
Published: December 2015

Mack Sennett (b. 1880–d. 1960), is a Canadian-born actor, director, and producer who headed two of the most influential and prolific American slapstick studios: the Keystone Film Company (1912–1917) and Mack Sennett Comedies (1917–1933). At Keystone, Sennett acted in, directed, and produced over 540 shorts, in addition to producing the first feature-length comedy, Tillie’s Punctured Romance, in 1914. Between 1917 and 1933 he produced some 440 short comedies and seventeen feature-length films under the banner of “Mack Sennett Comedies.” These motion pictures set the pace and style that established silent slapstick as an immensely popular film genre appreciated by masses of moviegoers. A second aspect of Sennett’s key position is his association with the early movie careers of an impressive roster of performers: Charles Chaplin, Mabel Normand, Roscoe “Fatty” Arbuckle, Ben Turpin, Harry Langdon, Carole Lombard, W. C. Fields, and Bing Crosby all grew to film stardom under his tutelage. He hired apprentice crew members before they became award-winning directors, cinematographers, and editors such as Frank Capra, Mal St. Clair, Fred Jackman, Vernon Walker, and William Hornbeck. His name is associated with bizarre phenomena, such as the incompetent Keystone cops or the bevy of beautiful Sennett Bathing Girls. After a successful transition to sound and color, Sennett returned to a position behind the camera to direct talking comedies. Following a disastrous distribution deal with Paramount Publix in 1932, Mack Sennett Comedies was forced to file for bankruptcy in 1933. Until his death in 1960 Sennett attempted a comeback, reediting his comedies into compilation films. In 1938 the Academy of Motion Picture Arts and Sciences honored Sennett with an Academy Award for his lasting contributions to screen comedy. Scholarly interest in Mack Sennett concentrates on the Keystone movies; their unpolished energy invites interpretations in many disciplines and theoretical frameworks. Sennett’s professional life coincides with the formative years of the Hollywood film industry, spurring critical literature on the relation between slapstick comedy and classical Hollywood cinema. Moreover, with his autobiography The King of Comedy, published in 1954, Sennett created a hilarious report that greatly colors our understanding of slapstick film production. Clearly, Mack Sennett not only embodied the history of slapstick comedy but also dictated the stories to remember it by. This article, then, studies Sennett’s role as legendary Hollywood figure and analyzes his comedies in theories of slapstick and comedy.
The Functional Status Score for the Intensive Care Unit Scale: Is It Reliable in the Intensive Care Unit? Can It Be Used to Determine Discharge Placement?
Authors: Ragavan Venkatesh Kenni , Greenwood Kristin Curry , Bibi Khalid 
Published: December 2015

Purpose:
To date there is little available information about the reliability of the Functional Status Score for the Intensive Care Unit (FSS-ICU) scale in the intensive care unit (ICU) environment. The purpose of this study is 2-fold: first to determine the FSS-ICU scale's interrater reliability; second to examine whether a relationship exists between a patient's FSS-ICU score on the day of ICU-to-regular ward transfer and the patient's ultimate discharge destination.

Methods:
The interrater reliability of the FSS-ICU scale was tested among 6 physical therapists who routinely worked in the ICU. The FSS-ICU scores on the day of ICU-to-ward transfer and final discharge destination were collected prospectively from 26 patients who received physical therapy intervention. Discharge destinations were divided into 5 categories: home, acute rehabilitation unit (ARU), skilled nursing facility (SNF), assisted living facility (ALF), and others.

Results:
Interrater reliability of the FSS-ICU scale was high (intraclass correlation coefficient = 0.992, 95% confidence interval) among the physical therapists who routinely worked in the ICU settings, and the median cumulative FSS-ICU scores on the day of ICU-to-ward transfer were significantly different among each of the discharge categories.

Conclusions:
Interrater reliability of the FSS-ICU scale was high among physical therapists who routinely worked in the ICU and who were familiar with the scale. This scale may have potential value to discriminate between different discharge destinations in a hospital setting, but further research is warranted.