bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the central management of risk networks
Authors: Avram Florin , Minca Andreea 
Published: March 2017

Abstract
In this paper we identify three questions concerning the management of risk networks with a central branch, which may be solved using the extensive machinery available for one-dimensional risk models. First, we propose a criterion for judging whether a subsidiary is viable by its readiness to pay dividends to the central branch, as reflected by the optimality of the zero-level dividend barrier. Next, for a deterministic central branch which must bailout a single subsidiary each time its surplus becomes negative, we determine the optimal bailout policy, as well as the ruin probability and other risk measures, in closed form. Moreover, we extend these results to the case of hierarchical networks. Finally, for nondeterministic central branches with one subsidiary, we compute approximate risk measures by applying rational approximations, and by using the recently developed matrix scale methodology.
Estimation of entropy for Poisson marked point processes
Authors: Alonso-Ruiz P. , Spodarev E. 
Published: March 2017

Abstract
In this paper a kernel estimator of the differential entropy of the mark distribution of a homogeneous Poisson marked point process is proposed. The marks have an absolutely continuous distribution on a compact Riemannian manifold without boundary. We investigate L2 and the almost surely consistency of this estimator as well as its asymptotic normality.
Genealogies of two linked neutral loci after a selective sweep in a large population of stochastically varying size
Authors: Brink-Spalink Rebekka , Smadi Charline 
Published: March 2017

AbstractWe study the impact of a hard selective sweep on the genealogy of partially linked neutral loci in the vicinity of the positively selected allele. We consider a sexual population of stochastically varying size and, focusing on two neighboring loci, derive an approximate formula for the neutral genealogy of a sample of individuals taken at the end of the sweep. Individuals are characterized by ecological parameters depending on their genetic type, and governing their growth rate and interactions with other individuals (competition). As a consequence, the `fitness' of an individual depends on the population state and is not an intrinsic characteristic of individuals. We provide a deep insight into the dynamics of the mutant and wild-type populations during the different stages of a selective sweep.
Perception verb complements in Spanish: same or different?
Authors: Suñer Margarita 
Published: March 2017

Introduction. In Spanish, pairs of sentences like the following are found:
(1)a.Oigo que Juan toca la guitarra.I-hear that John is-playing the the guitar.b.Oigo a Juan que toca la guitarra.I-hear John that (he) is-playing the guitar.(2)a.Vio que María estaba de regreso.He-saw that Mary had returned.b.Vio a María que estaba de regreso.He-saw Mary that (she) had returned.(3)a.Veo que el río trae mucha agua.I-see that the river carries a-lot-of waterb.Veo el río que trae mucha agua.I-see the river that (it) carries a-lot-of water.In general, it appears that in sentences with verbs of perception which introduce a que clause, the embedded subject (see a. sentences) is able to move upwards to the object position in the main clause (see b. sentences). This pattern also occurs in the causative construction with dejar.(4)a.Dejé que Juan saliera.I-let that John leave (Subjunctive)b.Dejé a Juan que saliera.I-let John that (he) leave (Subjunctive)
La Linguistique au congrès de l’acfas
Authors: Vachon-Spilka Irène 
Published: March 2017

Le vingt-neuvième congrès de l’Acfas se tenait à l’Université d’Ottawa les 27, 28 et 29 Octobre 1961. Les membres de la section de Linguistique se sont réunis sous la présidence de MM. Jean-Paul Vinay et Roch Valin.Voici le titre des communications qui ont été prononcées ainsi qu’un bref résumé de chacune d’elles.
A note on the topological sliceness of some 2-bridge knots
Authors: MILLER ALLISON N. 
Published: March 2017

AbstractWe use twisted Alexander polynomials to show that certain algebraically slice 2-bridge knots are not topologically slice, even though all prime power Casson–Gordon signatures vanish. We also provide some computations indicating the efficacy of Casson–Gordon signatures in obstructing the smooth sliceness of 2-bridge knots.
Personal safety issues in the lives of children with learning disabilities
Authors: Briggs Freda , Hawkins Russell 
Published: March 2017

An earlier evaluation of the New Zealand child protection program ‘Keeping Ourselves Safe’ found, inter alia, that girls with learning problems were highly vulnerable to drugs, sexual abuse and violence (Briggs & Hawkins 1996a). This led to the present study, the aim of which was to focus specifically on children with learning disabilities, and to include data from boys as well as girls.Quantitative and qualitative data were collected from one hundred and sixteen students aged 11–17 years (61 females and 55 males) who were interviewed in special education units. Their common characteristics were that they had all been assessed as being 3 years or more behind their chronological age group in their development and achievement, they needed individually planned curricula across the range of school subjects, and they had all previously attended mainstream schools throughout the North and South Islands of New Zealand.The study confirmed the vulnerability of children with learning disabilities to the risks of drugs, violence, psychological bullying, pornography and sexual abuse. Significant levels of violence in both schools and the home were found. The study also showed the need for special attention for the protection of boys.It is possible that children with learning disabilities were targeted because they were seen as safer targets in terms of an expectation that they would be less aware of the difference between right and wrong and less likely than other children to make a report about any abusive behaviour. If this speculative hypothesis is correct, it means that children with learning disabilities require even more vigilant forms of protection than other children.
Vulnerability to omega-3 deprivation in a mouse model of NMDA receptor hypofunction
Authors: Islam Rehnuma , Trépanier Marc-Olivier , Milenkovic Marija , Horsfall Wendy , Salahpour Ali , Bazinet Richard P. , Ramsey Amy J. 
Published: March 2017

AbstractSeveral studies have found decreased levels of ω-3 polyunsaturated fatty acids in the brain and blood of schizophrenia patients. Furthermore, dietary ω-3 supplements may improve schizophrenia symptoms and delay the onset of first-episode psychosis. We used an animal model of NMDA receptor hypofunction, NR1KD mice, to understand whether changes in glutamate neurotransmission could lead to changes in brain and serum fatty acids. We further asked whether dietary manipulations of ω-3, either depletion or supplementation, would affect schizophrenia-relevant behaviors of NR1KD mice. We discovered that NR1KD mice have elevated brain levels of ω-6 fatty acids regardless of their diet. While ω-3 supplementation did not improve any of the NR1KD behavioral abnormalities, ω-3 depletion exacerbated their deficits in executive function. Omega-3 depletion also caused extreme mortality among male mutant mice, with 75% mortality rate by 12 weeks of age. Our studies show that alterations in NMDAR function alter serum and brain lipid composition and make the brain more vulnerable to dietary ω-3 deprivation.
Grating chips for quantum technologies
Authors: McGilligan James P. , Griffin Paul F. , Elvin Rachel , Ingleby Stuart J. , Riis Erling , Arnold Aidan S. 
Published: March 2017

AbstractWe have laser cooled 3 × 106 87Rb atoms to 3 μK in a micro-fabricated grating magneto-optical trap (GMOT), enabling future mass-deployment in highly accurate compact quantum sensors. We magnetically trap the atoms, and use Larmor spin precession for magnetic sensing in the vicinity of the atomic sample. Finally, we demonstrate an array of magneto-optical traps with a single laser beam, which will be utilised for future cold atom gradiometry.
Palmitoylethanolamide induces microglia changes associated with increased migration and phagocytic activity: involvement of the CB2 receptor
Authors: Guida F. , Luongo L. , Boccella S. , Giordano M. E. , Romano R. , Bellini G. , Manzo I. , Furiano A. , Rizzo A. , Imperatore R. , Iannotti F. A. , D’Aniello E. , Piscitelli F. , sca Rossi F. , Cristino L. , Di Marzo V. , de Novellis V. , Maione S. 
Published: March 2017

AbstractThe endogenous fatty acid amide palmitoylethanolamide (PEA) has been shown to exert anti-inflammatory actions mainly through inhibition of the release of pro-inflammatory molecules from mast cells, monocytes and macrophages. Indirect activation of the endocannabinoid (eCB) system is among the several mechanisms of action that have been proposed to underlie the different effects of PEA in vivo. In this study, we used cultured rat microglia and human macrophages to evaluate whether PEA affects eCB signaling. PEA was found to increase CB2 mRNA and protein expression through peroxisome proliferator-activated receptor-α (PPAR-α) activation. This novel gene regulation mechanism was demonstrated through: (i) pharmacological PPAR-α manipulation, (ii) PPAR-α mRNA silencing, (iii) chromatin immunoprecipitation. Moreover, exposure to PEA induced morphological changes associated with a reactive microglial phenotype, including increased phagocytosis and migratory activity. Our findings suggest indirect regulation of microglial CB2R expression as a new possible mechanism underlying the effects of PEA. PEA can be explored as a useful tool for preventing/treating the symptoms associated with neuroinflammation in CNS disorders.
Fgf21 regulates T-cell development in the neonatal and juvenile thymus
Authors: Nakayama Yoshiaki , Masuda Yuki , Ohta Hiroya , Tanaka Tomohiro , Washida Miwa , Nabeshima Yo-ichi , Miyake Ayumi , Itoh Nobuyuki , Konishi Morichika 
Published: March 2017

AbstractWe have previously shown that Fibroblast growth factor 21 (Fgf21) is expressed in the thymus as well as in the liver. In line with this expression profile, Fgf21 was recently reported to protect against ageing-related thymic senescence by improving the function of thymic epithelial cells (TECs). However, the function of Fgf21 in the juvenile thymus remained to be elucidated. We investigated the physiological roles of Fgf21 in the juvenile thymus and found that young Fgf21 knockout mice, but not β-Klotho knockout mice nor adult Fgf21 knockout mice, showed a significant reduction in the percentage of single-positive CD4+ and CD8+ thymocytes without obvious alteration in TECs. Furthermore, treatment with recombinant FGF21 protein rescued the impairment in fetal thymus organ culture (FTOC) of Fgf21 knockout mice. Annexin V staining revealed FGF21 protein enhanced apoptosis of immature thymocytes undergoing selection process in FTOC, suggesting that FGF21 may facilitate the selection of developing T cells. Endocrine Fgf21 from the liver induced by metabolic stimulation did not affect juvenile thymocyte development. Our data suggest that Fgf21 acts as one of intrathymic cytokines in the neonatal and juvenile thymus, involving thymocyte development in a β-Klotho-independent manner.
Expression of canine distemper virus receptor nectin-4 in the central nervous system of dogs
Authors: Pratakpiriya Watanyoo , Ping Teh Angeline Ping , Radtanakatikanon Araya , Pirarat Nopadon , Thi Lan Nguyen , Takeda Makoto , Techangamsuwan Somporn , Yamaguchi Ryoji 
Published: March 2017

AbstractCanine distemper virus (CDV) exhibits lymphotropic, epitheliotropic, and neurotropic nature, and causes a severe systemic infection in susceptible animals. Initially, signaling lymphocyte activation molecule (SLAM) expressed on immune cells has been identified as a crucial cellular receptor for CDV. Currently, nectin-4 expressed in epithelia has been shown to be another receptor for CDV. Our previous study demonstrated that neurons express nectin-4 and are infected with CDV. In this study, we investigated the distribution pattern of nectin-4 in various cell types in the canine central nervous system and showed its relation to CDV infection to further clarify the pathology of disease. Histopathological, immunohistochemical and immunofluorescent analyses were done using formalin-fixed paraffin-embedded tissues of CDV-infected dogs. Dual staining of nectin-4 and CDV antigen or nectin-4 and brain cell markers was performed. Nectin-4 was detected in ependymal cells, epithelia of choroid plexus, meningeal cells, neurons, granular cells, and Purkinje’s cells. CDV antigens were detected in these nectin-4-positive cells, further suggesting contribution of nectin-4 for the CDV neurovirulence. On the other hand, astrocytes did not express nectin-4, although they were frequently infected with CDV. Since astrocytes are negative for SLAM expression, they must express an unidentified CDV receptor, which also contributes to CDV neurovirulence.
A Novel Method of Evaluating Knee Joint Stability of Patients with Knee Osteoarthritis: Multiscale Entropy Analysis with A Knee-Aiming Task
Authors: Zhou Diange , Zhang Shijie , Zhang Hui , Jiang Long , Zhang Jue , Fang Jing 
Published: March 2017

AbstractDeteriorating knee stability is a local risk factor that reflects the occurrence and aggregative of osteoarthritis (OA). Despite the many biomechanics-based methods for assessing the structural stability of knee joints in clinics, these methods have many limitations. The stability of the knee joint relies on not only biomechanical factors, but also proprioception and the central nervous system. In this study, we attempt to depict the stability of knee joint from a holistic viewpoint, and a novel index of knee joint stability (IKJS) was thus extracted. We compared the differences of IKJS in 57 healthy volunteers and 55 patients with OA before and after total knee replacement (TKR). Analysis of Variance results demonstrated that there existed significant differences in IKJS among the three participating groups (<0.0001). Also, the IKJS of the operated leg in patients with knee OA increased remarkably after TKR (p < 0.0001). Furthermore, the results of the experiment suggested that the IKJS has sufficient reproducibility (ICC = 0.80). In conclusion, the proposed IKJS that employs the knee-aiming task is feasible for quantitatively determining knee stability. It can provide a potentially valuable and convenient tool to evaluate the effect of postoperative rehabilitation for patients with knee OA.
Optomechanically induced transparency of x-rays via optical control
Authors: Liao Wen-Te , Pálffy Adriana 
Published: March 2017

AbstractThe search for new control methods over light-matter interactions is one of the engines that advances fundamental physics and applied science alike. A specific class of light-matter interaction interfaces are setups coupling photons of distinct frequencies via matter. Such devices, nontrivial in design, could be endowed with multifunctional tasking. Here we envisage for the first time an optomechanical system that bridges optical and robust, high-frequency x-ray photons, which are otherwise notoriously difficult to control. The x-ray-optical system comprises of an optomechanical cavity and a movable microlever interacting with an optical laser and with x-rays via resonant nuclear scattering. We show that optomechanically induced transparency of a broad range of photons (10 eV–100 keV) is achievable in this setup, allowing to tune nuclear x-ray absorption spectra via optomechanical control. This paves ways for metrology applications, e.g., the detection of the 229Thorium clock transition, and an unprecedentedly precise control of x-rays using optical photons.
Real-time observational evidence of changing Asian dust morphology with the mixing of heavy anthropogenic pollution
Authors: Pan Xiaole , Uno Itsushi , Wang Zhe , Nishizawa Tomoaki , Sugimoto Nobuo , Yamamoto Shigekazu , Kobayashi Hiroshi , Sun Yele , Fu Pingqing , Tang Xiao , Wang Zifa 
Published: March 2017

AbstractNatural mineral dust and heavy anthropogenic pollution and its complex interactions cause significant environmental problems in East Asia. Due to restrictions of observing technique, real-time morphological change in Asian dust particles owing to coating process of anthropogenic pollutants is still statistically unclear. Here, we first used a newly developed, single-particle polarization detector and quantitatively investigate the evolution of the polarization property of backscattering light reflected from dust particle as they were mixing with anthropogenic pollutants in North China. The decrease in observed depolarization ratio is mainly attributed to the decrease of aspect ratio of the dust particles as a result of continuous coating processes. Hygroscopic growth of Calcium nitrate (Ca(NO3)2) on the surface of the dust particles played a vital role, particularly when they are stagnant in the polluted region with high RH conditions. Reliable statistics highlight the significant importance of internally mixed, ‘quasi-spherical’ Asian dust particles, which markedly act as cloud condensation nuclei and exert regional climate change.
Exposure to an acute hypoxic stimulus during early life affects the expression of glucose metabolism-related genes at first-feeding in trout
Authors: Liu Jingwei , Plagnes-Juan Elisabeth , Geurden Inge , Panserat Stéphane , Marandel Lucie 
Published: March 2017

AbstractRainbow trout (Oncorhynchus mykiss) is considered a “glucose-intolerant” species. With the aim of programming trout to improve their metabolic use of dietary carbohydrates, we hypothesised that a hypoxic stimulus applied during embryogenesis could later affect glucose metabolism at the first-feeding stage. An acute hypoxic stimulus (2.5 or 5.0 mg·L−1 O2) was applied for 24 h to non-hatched embryos or early hatched alevins followed by a challenge test with a high carbohydrate diet at first-feeding. The effectiveness of the early hypoxic stimulus was confirmed by the induction of oxygen-sensitive markers such as egln3. At first-feeding, trout previously subjected to the 2.5 mg·L−1 O2 hypoxia displayed a strong induction of glycolytic and glucose transport genes, whereas these glucose metabolism-related genes were affected much less in trout subjected to the less severe (5.0 mg·L−1 O2) hypoxia. Our results demonstrate that an acute hypoxic stimulus during early development can affect glucose metabolism in trout at first-feeding.
Angiotensin II promotes the anticoagulant effects of rivaroxaban via angiotensin type 2 receptor signaling in mice
Authors: Yang Dan , Shao Junjie , Hu Ruifeng , Chen Haimei , Xie Ping , Liu Chang 
Published: March 2017

AbstractRivaroxaban is an oral direct factor Xa inhibitor approved for the treatment of stroke and systemic thromboembolism in patients with non-valvular atrial fibrillation. Despite its efficacy, rivaroxaban therapy results in adverse effects and complications, such as bleeding. Angiotensin II (AngII) is implicated in many cardiovascular conditions, such as hypertension and heart failure. In this study, we investigate whether AngII influences anticoagulant effects of rivaroxaban by using an experimental mouse model with type 2 diabetes mellitus and advanced glycation end product (AGE)-exposed human umbilical vein endothelial cells (HUVECs). We found that AngII promoted the anticoagulant effects of rivaroxaban in KKAy mice. The combination of rivaroxaban and AngII enhanced in vivo tissue factor pathway inhibitor (TFPI) activity and induced TFPI expression and activity in AGE-exposed HUVECs. Angiotensin type 2 receptor (AT2R) and Mas antagonists attenuated the AngII-enhanced anticoagulant action of rivaroxaban in vivo, and abolished the increased endothelial TFPI expression and activity. However, angiotensin type 1 receptor (AT1R) antagonist exerted no effects. Additionally, combination of rivaroxaban and AngII induced aortic AT2R and Mas expression. Our data suggest that the anticoagulant effects of rivaroxaban are promoted by AngII via AT2R and Mas signaling. These findings are significant for the clinical administration of rivaroxaban.
Low-frequency stimulation of the primary focus retards positive transfer of secondary focus
Authors: Kuang Yifang , Xu Cenglin , Zhang Yinxi , Wang Yi , Wu Xiaohua , Wang Ying , Liu Yao , Zhong Kai , Cheng Hui , Guo Yi , Wang Shuang , Ding Meiping , Chen Zhong 
Published: March 2017

AbstractPositive transfer of secondary focus (PTS) refers to new epileptogenesis outside the primary focus and is minimally controlled by existing treatments. Low-frequency stimulation (LFS) has benefits on the onset of epilepsy and epileptogenesis. However, it’s unclear whether LFS can retard the PTS in epilepsy. Here we found that PTS at both contralateral amygdala and ipsilateral hippocampus were promoted after the primary focus was fully kindled in rat kindling model. The promotion of PTS at the mirror focus started when the primary kindling acquisition reached focal seizures. LFS retarded the promotion of PTS when it was applied at the primary focus during its kindling acquisition, while it only slightly retarded the promotion of PTS when applied after generalized seizures. Meanwhile, we found the expression of potassium chloride cotransporter 2 (KCC2) decreased during PTS, and LFS reversed this. Further, the decreased expression of KCC2 was verified in patients with PTS. These findings suggest that LFS may be a potential therapeutic approach for PTS in epilepsy.
Preservation of organic matter in marine sediments by inner-sphere interactions with reactive iron
Authors: Barber Andrew , Brandes Jay , Leri Alessandra , Lalonde Karine , Balind Kathryn , Wirick Sue , Wang Jian , Gélinas Yves 
Published: March 2017

AbstractInteractions between organic matter and mineral matrices are critical to the preservation of soil and sediment organic matter. In addition to clay minerals, Fe(III) oxides particles have recently been shown to be responsible for the protection and burial of a large fraction of sedimentary organic carbon (OC). Through a combination of synchrotron X-ray techniques and high-resolution images of intact sediment particles, we assessed the mechanism of interaction between OC and iron, as well as the composition of organic matter co-localized with ferric iron. We present scanning transmission x-ray microscopy images at the Fe L3 and C K1 edges showing that the organic matter co-localized with Fe(III) consists primarily of C=C, C=O and C-OH functional groups. Coupling the co-localization results to iron K-edge X-ray absorption spectroscopy fitting results allowed to quantify the relative contribution of OC-complexed Fe to the total sediment iron and reactive iron pools, showing that 25–62% of total reactive iron is directly associated to OC through inner-sphere complexation in coastal sediments, as much as four times more than in low OC deep sea sediments. Direct inner-sphere complexation between OC and iron oxides (Fe-O-C) is responsible for transferring a large quantity of reduced OC to the sedimentary sink, which could otherwise be oxidized back to CO2.