bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fisher Motion Descriptor for Multiview Gait Recognition
Authors: Castro F.M. , Marín-Jiménez M.J. , Mata N.Guil , Muñoz-Salinas R. 
Published: July 2016

The goal of this paper is to identify individuals by analyzing their gait. Instead of using binary silhouettes as input data (as done in many previous works) we propose and evaluate the use of motion descriptors based on densely sampled short-term trajectories. We take advantage of state-of-the-art people detectors to define custom spatial configurations of the descriptors around the target person, obtaining a rich representation of the gait motion. The local motion features (described by the Divergence-Curl-Shear descriptor [M. Jain, H. Jegou and P. Bouthemy, Better exploiting motion for better action recognition, in Proc. IEEE Conf. Computer Vision Pattern Recognition (CVPR) (2013), pp. 2555–2562.]) extracted on the different spatial areas of the person are combined into a single high-level gait descriptor by using the Fisher Vector encoding [F. Perronnin, J. Sánchez and T. Mensink, Improving the Fisher kernel for large-scale image classification, in Proc. European Conf. Computer Vision (ECCV) (2010), pp. 143–156]. The proposed approach, coined Pyramidal Fisher Motion, is experimentally validated on ‘CASIA’ dataset [S. Yu, D. Tan and T. Tan, A framework for evaluating the effect of view angle, clothing and carrying condition on gait recognition, in Proc. Int. Conf. Pattern Recognition, Vol. 4 (2006), pp. 441–444]. (parts B and C), ‘TUM GAID’ dataset, [M. Hofmann, J. Geiger, S. Bachmann, B. Schuller and G. Rigoll, The TUM Gait from Audio, Image and Depth (GAID) database: Multimodal recognition of subjects and traits, J. Vis. Commun. Image Represent. 25(1) (2014) 195–206]. ‘CMU MoBo’ dataset [R. Gross and J. Shi, The CMU Motion of Body (MoBo) database, Technical Report CMU-RI-TR-01-18, Robotics Institute (2001)]. and the recent ‘AVA Multiview Gait’ dataset [D. López-Fernández, F. Madrid-Cuevas, A. Carmona-Poyato, M. Marín-Jiménez and R. Muñoz-Salinas, The AVA multi-view dataset for gait recognition, in Activity Monitoring by Multiple Distributed Sensing, Lecture Notes in Computer Science (Springer, 2014), pp. 26–39]. The results show that this new approach achieves state-of-the-art results in the problem of gait recognition, allowing to recognize walking people from diverse viewpoints on single and multiple camera setups, wearing different clothes, carrying bags, walking at diverse speeds and not limited to straight walking paths.
Treatment of acute pulmonary embolism with dabigatran versus warfarin
Authors: Schellong Sebastian , Kakkar Ajay , Eriksson Henry , Feuring Martin , Kreuzer Joerg , Fraessdorf Mandy , Schulman Sam , Goldhaber Samuel Z. 
Published: July 2016

SummaryDabigatran was non-inferior to warfarin for prevention of recurrent venous thromboembolism (VTE), and dabigatran had a lower rate of bleeding compared with warfarin in two large-scale randomised trials, RE-COVER and RE-COVER II. In this study, we investigate the efficacy and safety of dabigatran versus warfarin according to the index event that qualified the patient for enrollment, either symptomatic pulmonary embolism (PE) with or without deep-vein thrombosis (DVT), or DVT alone. We then analyse the anticoagulant effect of dabigatran vs warfarin on patients enrolled with PE. The pooled dataset for the efficacy analysis consisted of 2553 and 2554 patients who were randomised to dabigatran and warfarin, respectively. Recurrent VTE/VTE-related death during the study period and additional 30-day follow-up occurred in 2.7 % of all patients on dabigatran and in 2.4 % on warfarin (hazard ratio [HR] 1.09 [95 % confidence interval 0.77, 1.54]). In patients with PE as their index event, recurrent VTE/VTE-related death occurred in 2.9 % vs 3.1 % of patients (HR 0.93 [0.53, 1.64]). There were significantly fewer major bleeding events in patients treated with dabigatran than with warfarin (HR 0.60 [0.36, 0.99]). The pattern was similar both in patients with PE and in those with DVT alone as the index event. These analyses of the pooled dataset from the RECOVER and RE-COVER II trials indicate that dabigatran is as effective as warfarin in preventing recurrent VTE, regardless of whether patients present with symptomatic PE (with or without DVT) or with symptomatic DVT alone. Dabigatran was also associated with a lower risk of bleeding than warfarin, regardless of the index event.
Right Atrial Approach for Ablation of Ventricular Arrhythmias Arising From the Left Posterior–Superior Process of the Left Ventricle
Authors: Santangeli Pasquale , Hutchinson Mathew D. , Supple Gregory E. , Callans David J. , Marchlinski Francis E. , Garcia Fermin C. 
Published: July 2016

Background—
The posterior–superior process of the left ventricle (PSP-LV) is the most inferior and posterior aspect of the basal LV that extends posteriorly to the plane of the tricuspid valve. The PSP-LV is anatomically adjacent to the inferior and medial aspect of the right atrium (RA). We report a series of patients with ventricular arrhythmias (VAs) arising from the PSP-LV and describe a mapping and ablation approach from the RA guided by intracardiac echocardiography.

Methods and Results—

Mapping and ablation of the PSP-LV with an RA approach under intracardiac echocardiography guidance were performed in 5 patients with VAs (aged 44±14 years, 2 males) who had failed ablation attempts from multiple endocardial and epicardial (1 patient) sites. Mapping of the PSP-LV from the adjacent inferomedial RA was performed at sites anatomically opposite to the earliest endocardial site of activation under direct intracardiac echocardiography visualization. From the RA side of the PSP-LV, a small atrial signal and a larger ventricular signal were recorded in each case, with an activation time of 32±7 ms pre-QRS (versus 16±5 ms pre-QRS in the LV endocardium;
P
=0.068). We were able to capture the LV from these sites. Cryoablation was performed in 2 patients, and radiofrequency was used in the remaining 3 cases. In all patients, ablation from the RA eliminated the arrhythmia. All patients remained free of recurrent VAs after a mean follow-up of 12 (7–16) months. There were no immediate or long-term complications.

Conclusions—
The PSP-LV can be a site of origin of VAs, which can be successfully eliminated from the adjacent RA under direct intracardiac echocardiographic visualization.
Marijuana and Listing for Heart Transplant
Authors: Neyer Jonathan , Uberoi Abhimanyu , Hamilton Michele , Kobashigawa Jon A. 
Published: July 2016

Background—
There is no consensus within the heart transplant community about whether patients who use marijuana should be eligible for transplant listing, but several states have passed legislation prohibiting marijuana-using patients from being denied transplant listing based on their use of the substance.

Methods and Results—
We conducted an independent, voluntary, web-based survey of heart and lung transplant providers to assess current practice patterns and attitudes toward marijuana use in patients with advanced heart failure being considered for transplant. A total of 360 heart transplant providers responded from 26 countries. Nearly two thirds of respondents (n=222, 64.4%) supported listing patients with advanced, end-stage heart failure for transplant who use legal medical marijuana. Significantly, fewer respondents (n=96, 27.5%) supported transplant listing for patients using legal recreational marijuana. The majority of providers currently make patients eligible for transplantation after a period of abstinence from marijuana (n=241, 68.3%). There were no differences between the proportion of respondents supporting transplant listing after stratification by profession or country/region. Most (78.4%) survey respondents from states with laws prohibiting marijuana-using patients from being denied transplant listing reported denying all marijuana-using patients or mandating abstinence before transplant listing.

Conclusions—
The majority of heart and lung transplant providers in our study sample supports the listing of patients who use medical marijuana for transplant after a period of abstinence. Communication and collaboration between the medical community and legislative groups about marijuana use in transplant candidates is needed to ensure the best patient outcomes with the use of scarce donor organs.
Randomized Comparison of a Biodegradable Polymer Ultrathin Strut Sirolimus-Eluting Stent With a Biodegradable Polymer Biolimus-Eluting Stent in Patients Treated With Percutaneous Coronary Intervention
Authors: Jensen Lisette Okkels , Thayssen Per , Maeng Michael , Ravkilde Jan , Krusell Lars Romer , Raungaard Bent , Junker Anders , Terkelsen Christian Juhl , Veien Karsten Tange , Villadsen Anton Boel , Kaltoft Anne , Tilsted Hans-Henrik , Hansen Knud Nørregaard , Aaroe Jens , Kristensen Steen Dalby , Hansen Henrik Steen , Jensen Svend Eggert , Madsen Morten , Bøtker Hans Erik , Berencsi Klára , Lassen Jens Flensted , Christiansen Evald Høj 
Published: July 2016

Background—
Coronary drug-eluting stents with biodegradable polymers have been designed to improve safety and efficacy.

Methods and Results—

The Scandinavian Organization for Randomized Trials With Clinical Outcome (SORT OUT) VII trial—a large-scale registry-based randomized, multicenter, single-blind, 2-arm, noninferiority trial—compared 2 biodegradable polymer drug-eluting stents: the thin-strut cobalt–chromium sirolimus-eluting Orsiro stent and the stainless steel biolimus-eluting Nobori stent in an all-comer patient population. The primary end point target lesion failure was a composite of cardiac death, myocardial infarction (not related to other than index lesion), or target lesion revascularization within 1 year, analyzed by intention to treat (noninferiority margin of 3.0%). Clinically driven event detection based on Danish registries was used. A total of 1261 patients were assigned to receive the sirolimus-eluting stent (1590 lesions) and 1264 patients to the biolimus-eluting stent (1588 lesions). At 1 year, the composite end point target lesion failure occurred in 48 patients (3.8%) in the sirolimus-eluting group and in 58 patients (4.6%) in the biolimus-eluting group (absolute risk difference, −0.78% [upper limit of 1-sided 95% confidence interval, 0.61%];
P
<0.0001). Rates of definite stent thrombosis occurred in 5 (0.4%) of the sirolimus-eluting group compared with 15 (1.2%) biolimus-eluting stent–treated patients (rate ratio, 0.33; 95% confidence interval, 0.12–0.92;
P
=0.034), which largely was attributable to a lower risk of subacute definite stent thrombosis: 0.1% versus 0.6% (rate ratio, 0.12; 95% confidence interval, 0.02–1.00;
P
=0.05).

Conclusions—
The thin-strut sirolimus-eluting Orsiro stent was noninferior to the biolimus-eluting Nobori stent in unselected patients for target lesion failure at 1 year.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01879358.
Glibenclamide Is Comparable to Target Temperature Management in Improving Survival and Neurological Outcome After Asphyxial Cardiac Arrest in Rats
Authors: Huang Kaibin , Wang Ziyue , Gu Yong , Hu Yafang , Ji Zhong , Wang Shengnan , Lin Zhenzhou , Li Xing , Xie Zuoshan , Pan Suyue 
Published: July 2016

Background

We previously have shown that glibenclamide (
GBC
), a sulfonylurea receptor 1–transient receptor potential M4 (
SUR
1‐
TRPM
4) channel inhibitor, improves survival and neurological outcome after asphyxial cardiac arrest and cardiopulmonary resuscitation (
ACA
/
CPR
). Here, we further compare the efficacy of
GBC
with target temperature management (
TTM
) and determine whether the efficacy of
GBC
is affected by
TTM
.

Methods and Results

Male Sprague‐Dawley rats (n=213) subjected to 10‐minute
ACA
/
CPR
were randomized to 4 groups after return of spontaneous circulation (
ROSC
): normothermia control (
NT
);
GBC
;
TTM
; and
TTM
+
GBC
. Survival, neurodeficit scores, histological injury, as well as the expressions of
SUR
1 and
TRPM
4 were evaluated. The 7‐day survival rate was 34.4% (11 of 32) in the
NT
group, 65% (13 of 20) in the
GBC
group, 50% (10 of 20) in the
TTM
group, and 70% (14 of 20) in the
TTM
+
GBC
group. Rats that received either
GBC
,
TTM
alone, or in combination showed less neurological deficit than
NT
control at 24, 48, and 72 hours and 7 days after
ROSC
. Moreover,
TTM
or
GBC
ameliorated neuronal degeneration and glial activation in the hippocampal
CA
1 region with similar efficacy, whereas the combination of them had a trend toward better effect. The subunits of
SUR
1‐
TRPM
4 heterodimers were both strongly upregulated after
ACA
/
CPR
and expressed in multiple types of brain cells, but partly suppressed by
TTM
.

Conclusions

GBC
is comparable to
TTM
in improving survival and neurological outcome after
ACA
/
CPR
. When
GBC
is given along with
TTM
, less histological injury tended to be achieved.
Obesity Is Associated With Progression of Atherosclerosis During Statin Treatment
Authors: Sandfort Veit , Lai Shenghan , Ahlman Mark A. , Mallek Marissa , Liu Songtao , Sibley Christopher T. , Turkbey Evrim B. , Lima João A. C. , Bluemke David A. 
Published: July 2016

Background
This study aimed to determine the relationship of statin therapy and cardiovascular risk factors to changes in atherosclerosis in the carotid artery.

Methods and Results

Carotid magnetic resonance imaging was used to evaluate 106 hyperlipidemic participants at baseline and after 12 months of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase inhibitor (statin) treatment. Multivariable logistic regression was used to determine factors associated with progression (change in carotid wall volume >0) or regression (change ≤0) of carotid atherosclerosis. Computed tomography coronary calcium scores were obtained at baseline for all participants. The median age was 65 years (interquartile range 60–69 years), and 63% of the participants were male. Body mass index >30, elevated C‐reactive protein, and hypertension were associated with increased carotid wall volume (obesity: odds ratio for progression 4.6, 95%
CI
1.8–12.4,
P
<0.01; C‐reactive protein: odds ratio for progression 2.56, 95%
CI
1.17–5.73,
P
=0.02; hypertension: odds ratio 2.4, 95%
CI
1.1–5.3,
P
<0.05). Higher statin dose was associated with regression of carotid wall volume (
P
<0.05). In multivariable analysis, obesity remained associated with progression (
P
<0.01), whereas statin use remained associated with regression (
P
<0.05). Change in atheroma volume in obese participants was +4.8% versus −4.2% in nonobese participants (
P
<0.05) despite greater low‐density lipoprotein cholesterol reduction in obese participants.

Conclusions
In a population with hyperlipidemia, obese patients showed atheroma progression despite optimized statin therapy.

Clinical Trial Registration

URL
:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
01212900.
Effects of high hydrostatic pressure and thermal processing on bioactive compounds, antioxidant activity, and volatile profile of mulberry juice
Authors: Wang Fan , Du Bao-Lei , Cui Zheng-Wei , Xu Li-Ping , Li Chun-Yang 
Published: July 2016

The aim of this study was to investigate the effects of high hydrostatic pressure and thermal processing on microbiological quality, bioactive compounds, antioxidant activity, and volatile profile of mulberry juice. High hydrostatic pressure processing at 500 MPa for 10 min reduced the total viable count from 4.38 log cfu/ml to nondetectable level and completely inactivated yeasts and molds in raw mulberry juice, ensuring the microbiological safety as thermal processing at 85 ℃ for 15 min. High hydrostatic pressure processing maintained significantly (p < 0.05) higher contents of total phenolic, total flavonoid and resveratrol, and antioxidant activity of mulberry juice than thermal processing. The main volatile compounds of mulberry juice were aldehydes, alcohols, and ketones. High hydrostatic pressure processing enhanced the volatile compound concentrations of mulberry juice while thermal processing reduced them in comparison with the control. These results suggested that high hydrostatic pressure processing could be an alternative to conventional thermal processing for production of high-quality mulberry juice.
Intimacy between care home residents with dementia: Findings from a review of the literature
Authors: Wiskerke Esther , Manthorpe Jill 
Published: July 2016

Background There is limited research on what family members and frontline care home staff consider to be the best responses to the sexual expression of a person with dementia, whilst at the same time respecting relatives’ feelings, managing their possible distress and conflict, and how good practice should be reflected in care home policy and practice guidance. Methods This literature review explored what is known of the views of relatives and care workers of new relationships or sexual intimacy between care home residents with dementia, whilst still married to another person. It reports the findings of searches of three databases undertaken in August 2014 (Medline, Embase and PsychINFO). Findings Nine papers were found relevant to the research question. The following themes emerged from a synthesis of the papers located: sexuality in old age, dementia and sexuality, hyper-sexuality, views regarding sexuality of older people living in care homes, the law, ethics and consent, relationships and communication between care home and relatives, and new relationships or intimacy between residents with dementia. Conclusion While studies of residents’ expression of sexuality and their engaging in sexual behaviour with other resident(s) may be challenging to manage in care home settings and can be emotionally painful or uncomfortable for families, the review found that studies are few in number and span emotional intimacy and distressing behaviour.
Changes in the prevalence of hospitalization and comorbidity in US adults with stroke: A three decade cross-sectional and birth cohort analysis
Authors: Liu Longjian , Yang Xuan , Long Yong , Mallhi Arshpreet Kaur , Mehta Kathan , Veznedaroglu Erol , Yin Xiaoyan 
Published: July 2016

Background and purpose Little attention was paid to the transition of care for stroke that may partially explain the long-term trend of stroke rates. We aimed to test the trend of hospitalization attributable to stroke in US adults. Methods Data from National Hospital Discharge Surveys 1980–2010 in patients aged ≥18 (n = 6,527,304) were analyzed to examine the trend of patients with first-list diagnoses of stroke. Stroke comorbidities were classified in stroke patients with second- to seven-listed diagnoses of coronary heart disease, hypertension, diabetes, arrhythmias, or hyperlipidemia. Stroke trends by survey years and birth cohorts were analyzed using univariate, multivariate, and birth cohorts methods. Results Of the total study sample, the prevalence of hospitalization due to stroke was 22.99%, 30.00%, and 27.03% in years of 1980–1989, 1990–1999, and 2000–2010 in males, and 17.30%, 22.04%, and 19.34% in females, respectively. Overall, hospitalization rates in stroke patients significantly increased among adults aged <65, and decreased in adults aged ≥65. There was an increase in stroke hospitalization rate in the old adults aged ≥65 in recent birth cohorts. Significant increased trends of comorbid hypertension, diabetes, arrhythmias, and hyperlipidemia were observed from 1980 to 2010. Conclusion A significant increase in stroke hospitalization rate was observed in adults aged <65 in the past three decades, and in old adults in recent years. Increases in stroke comorbidity rates were observed in all age groups. Findings from the study highlight that both public health and clinical practices face a serious challenge in controlling this unwelcome increased stroke trend.
An Assessment of Levels of Safety in Psychiatric Units
Authors: Bayramzadeh Sara 
Published: July 2016

Objectives: This article aims to understand the incident patterns in relation to different types of spaces within a psychiatric unit, which are discussed using the five levels of safety framework. Background: Implementing measures to improve patient safety is essential particularly in a psychiatric hospital, where limited research has been conducted on inpatient safety. Therefore, this article aims to understand the incident patterns from the lens of the five levels of safety framework, which categorizes spaces according to the level of patient supervision in psychiatric facilities, as follows: service areas, corridors, dayrooms, patient rooms and bathrooms, seclusions and admissions. Methods: In an 81-bed psychiatric hospital, this mixed-method study drew 7 years of incident reports and caregivers’ perceptions gathered through focus groups. Incident reports on physical safety were analyzed based on the five levels of safety framework ( N = 1,316). Focus groups ( n = 9) explored the caregivers’ viewpoints on patient safety and five categories of spaces. Results: Overall findings support the five levels of safety pattern, confirming that most incidents occurred in patient rooms and bathrooms; moreover, relatively fewer incidents happened in dayrooms and corridors. Elopements are higher in hallways and dayrooms. Suicide is most common in patient rooms and bathrooms, and violence is more frequent in dayrooms. Focus groups results yielded insightful recommendations. Conclusions: Levels of safety framework can be adapted to seven categories where seclusion room and admission area would be two of the spaces with least incidents.
Indications and Efficacy of Gamma Knife Stereotactic Radiosurgery for Recurrent Glioblastoma: 2 Decades of Institutional Experience
Authors: Imber Brandon S. , Kanungo Ishan , Braunstein Steve , Barani Igor J. , Fogh Shannon E. , Nakamura Jean L. , Berger Mitchel S. , Chang Edward F. , Molinaro Annette M. , Cabrera Juan R. , McDermott Michael W. , Sneed Penny K. , Aghi Manish K. 
Published: July 2016

Abstract

BACKGROUND: The role of stereotactic radiosurgery (SRS) for recurrent glioblastoma and the radionecrosis risk in this setting remain unclear.

OBJECTIVE: To perform a large retrospective study to help inform proper indications, efficacy, and anticipated complications of SRS for recurrent glioblastoma.

METHODS: We retrospectively analyzed patients who underwent Gamma Knife SRS between 1991 and 2013. We used the partitioning deletion/substitution/addition algorithm to identify potential predictor covariate cut points and Kaplan-Meier and proportional hazards modeling to identify factors associated with post-SRS and postdiagnosis survival.

RESULTS: One hundred seventy-four glioblastoma patients (median age, 54.1 years) underwent SRS a median of 8.7 months after initial diagnosis. Seventy-five percent had 1 treatment target (range, 1-6), and median target volume and prescriptions were 7.0 cm3 (range, 0.3-39.0 cm3) and 16.0 Gy (range, 10-22 Gy), respectively. Median overall survival was 10.6 months after SRS and 19.1 months after diagnosis. Kaplan-Meier and multivariable modeling revealed that younger age at SRS, higher prescription dose, and longer interval between original surgery and SRS are significantly associated with improved post-SRS survival. Forty-six patients (26%) underwent salvage craniotomy after SRS, with 63% showing radionecrosis or mixed tumor/necrosis vs 35% showing purely recurrent tumor. The necrosis/mixed group had lower mean isodose prescription compared with the tumor group (16.2 vs 17.8 Gy; P = .003) and larger mean treatment volume (10.0 vs 5.4 cm3; P = .009).

CONCLUSION: Gamma Knife may benefit a subset of focally recurrent patients, particularly those who are younger with smaller recurrences. Higher prescriptions are associated with improved post-SRS survival and do not seem to have greater risk of symptomatic treatment effect.