bluuebunny/crossref_metadata_2025_split huggingface dataset:
SINHCAF/FAM60A links SIN3A function to the hypoxia response and its levels are predictive of cancer patient survival
Authors: Biddlestone John , Batie Michael , Shmakova Alena , Bandarra Daniel , Knatko Elena V. , Dinkova-Kostova Albena T. , Munoz Ivan , Sundaramoorthy Ramasubramanian , Owen-Hughes Tom , Rocha Sonia 
Published: August 2017

AbstractThe SIN3A-HDAC complex is a master transcriptional repressor, required for development but often deregulated in disease. Here, we report that the recently identified new component of this complex, SINHCAF/FAM60A, links the SIN3A-HDAC co-repressor complex function to the hypoxia response. SINHCAF Chromatin Immunoprecipitation-sequencing and gene expression analysis reveal a signature associated with the activation of the hypoxia response. We show that SINHCAF specifically repress HIF 2α mRNA and protein expression resulting in functional cellular changes inin-vitroangiogenesis, and proliferation. Analysis of patient datasets demonstrates that SINHCAF and HIF 2α mRNA levels are inversely correlated and predict contrasting outcomes for patient survival in both colon and lung cancer. This relationship is also observed in a mouse model of colon cancer, indicating an evolutionary conserved mechanism. Our analysis reveals an unexpected link between SINHCAF and cancer cell signalling via regulation of the hypoxia response that is predictive of poor patient outcome.
Prestimulus Activity in the Cingulo-Opercular Network Predicts Memory for Naturalistic Episodic Experience
Authors: Cohen Noga , Ben-Yakov Aya , Weber Jochen , Edelson Micah G. , Paz Rony , Dudai Yadin 
Published: August 2017

AbstractHuman memory is strongly influenced by brain states occurring before an event, yet we know little about the underlying mechanisms. We found that activity in the cingulo-opercular network (including bilateral anterior insula and anterior prefrontal cortex) seconds before an event begins can predict whether this event will subsequently be remembered. We then tested how activity in the cingulo-opercular network shapes memory performance. Our findings indicate that prestimulus cingulo-opercular activity affects memory performance by opposingly modulating subsequent activity in two sets of regions previously linked to encoding and retrieval of episodic information. Specifically, higher prestimulus cingulo-opercular activity was associated with a subsequent increase in activity in temporal regions previously linked to encoding and with a subsequent reduction in activity within a set of regions thought to play a role in retrieval and self-referential processing. Together, these findings suggest that prestimulus attentional states modulate memory for real-life events by enhancing encoding and possibly by dampening interference from competing memory substrates.
Encoding Sensory and Motor Patterns as Time-Invariant Trajectories in Recurrent Neural Networks
Authors: Goudar Vishwa , Buonomano Dean V. 
Published: August 2017

AbstractMuch of the information the brain processes and stores is temporal in nature—a spoken word or a handwritten signature, for example, is defined by how it unfolds in time. However, it remains unclear how neural circuits encode complex time-varying patterns. We show that by tuning the weights of a recurrent neural network (RNN), it can recognize and then transcribe spoken digits. The model elucidates how neural dynamics in cortical networks may resolve three fundamental challenges: first, encode multiple time-varying sensoryandmotor patterns as stable neural trajectories; second, generalize across relevant spatial features; third, identify the same stimuli played at different speeds—we show that this temporal invariance emerges because the recurrent dynamics generate neural trajectories with appropriately modulated angular velocities. Together our results generate testable predictions as to how recurrent networks may use different mechanisms to generalize across the relevant spatial and temporal features of complex time-varying stimuli.
Political radicalization and fragmentation of the democratic blocs and the legislative council elections in the Hong Kong Special Administrative Region
Authors: Hung Chung Fun Steven 
Published: August 2017

Purpose
After direct elections were instituted in Hong Kong and the sovereignty was transferred from Britain to China, politicization inevitably followed democratization. The purpose of this paper is to evaluate the pro-democratic political parties’ politics in Hong Kong in recent history.

Design/methodology/approach
The research was conducted through a historical comparative analysis, within the context of Hong Kong after the sovereignty handover and the interim period of crucial democratization.

Findings
With the implementation of “One country, Two systems,” political democratization was hindered in Hong Kong’s transformation. The democratic forces have no alternative but to seek more radicalized politics, which has caused a decisive and ineluctable fragmentation of the local political parties.

Originality/value
This paper explores and evaluates the political history of the Hong Kong Special Administrative Region under “One country, Two systems” and the ways in which the limited democratization hinders the progress of Hong Kong’s transformation.
A new wave of anti-mainland protests since 2012
Authors: So Alvin Y. 
Published: August 2017

Purpose
A new wave of anti-mainland protests has emerged in Hong Kong since 2012. The purpose of this paper is threefold: to delineate its unique characteristics; to trace its historical origins; and to speculate on the political implications of this new wave of anti-mainland protests.

Design/methodology/approach
A historical approach has been adopted to trace the origins of the anti-mainland protests. Since this new wave of anti-mainland protests only began in 2012, this paper is based mostly on documentary analysis of mass media reports.

Findings
This paper finds that this new wave of anti-mainland protests has been characterized by its targeting of mainland tourists/immigrants, its militancy, its concentration in the New Territories, its constituent membership of people from society’s grassroots, its dependence on e-mobilization and its poor image in Hong Kong’s mass media. In addition, this paper has identified the complex interplay between the influx of tourists/immigrants, the increase of social inequality, the emergence of a localist discourse, the formation of localist organizations and the setbacks to the democracy movement that are the underlying socio-political factors that have sparked this new wave of anti-mainland protests.

Social implications
Anti-mainland protests have profound implications for Hong Kong politics since they deepen socio-political polarization, have transformed the mode of protesting in Hong Kong society and threaten the prospects for the national reunification of Greater China.

Originality/value
This paper may be one of the first academic papers to examine the anti-mainland protests. Instead of taking a pro-Beijing or anti-mainland approach, this paper takes a neutral position and offers an objective analysis of the anti-mainland protests.
Hong Kong District Council elections 2015
Authors: Lam Jermain T.M. 
Published: August 2017

Purpose
The purpose of this paper is to analyze the results of Hong Kong’s 2015 District Council elections in order to test the repercussions of the Occupy Central Movement. The paper attempts to identify the political implications of the Movement as reflected by the 2015 election results.

Design/methodology/approach
The methodology used for the paper was to collect election data and conduct data analysis to generalize the political implications of the Occupy Central Movement.

Findings
The paper found that, first, Hong Kong is still polarized, as most voters were divided into those who supported the Occupy Central Movement and those who opposed it. Second, there is no consensus regarding political reforms, as most voters were split into two antagonistic positions. Third, the activists of the Occupy Central Movement have formed a new political force that attracts voters who demand change. Fourth, the Occupy Central Movement has become a breeding ground that nurtures localism.

Research limitations/implications
The 2015 District Council elections were a continuation of the Occupy Central Movement. The Movement affected the political balance between the pro-establishment and pan-democratic camps in the 2015 elections and it has shaped the democratization process in Hong Kong.

Originality/value
The paper was the product of an original research project that examined the results of the 2015 District Council elections to reflect on the implications of the Occupy Central Movement. The paper concluded that the 2015 elections sent important political messages to key political players in Hong Kong.
Critical factors affecting schedule performance
Authors: Sinesilassie Ephrem Girma , Tabish Syed Zafar Shahid , Jha Kumar Neeraj 
Published: August 2017

Purpose
Time overrun is one of the most significant issues being faced by Ethiopian construction industry today. For effective time performance, the successful execution of construction projects and keeping them within prescribed schedule is very important. The purpose of this paper is to determine the factors responsible for impacting performance of Ethiopian public construction projects.

Design/methodology/approach
Based on the literature and personal interviews of key construction professionals in Ethiopia, a list of 35 project performance attributes having strong effect on performance of the projects were identified and a questionnaire using these attributes were prepared and administered in Ethiopia. Statistical analysis of responses on the attributes segregated them into distinct sets of success attributes and failure attributes. The attributes were also subjected to factor analysis separately for better understanding and it resulted into six success factors and six failure factors. The relative importance of these factors was established with multiple regression analysis.

Findings
It is concluded that the success factor “owners’ competence” can significantly contribute to schedule performance of Ethiopian public construction projects. On the other hand, “conflict among project participants,” “poor human resource management,” and “project manager’s ignorance and lack of knowledge” are detrimental to schedule performance of Ethiopian public construction project.

Research limitations/implications
As with any other opinion-based study, the present study also has some limitations. The majority of respondents have evaluated the projects in their execution stage only and very few have evaluated the performance of projects in planning and operation stages and also the study has been carried out in the Ethiopian context. Hence the study has a limitation in these regard.

Originality/value
The results presented in this study provide sufficient evidence and useful understanding to researchers and industry practitioners to focus on a few factors than giving attention to all the factors and take proactive measures for the timely delivery of public construction projects.
Modeling schedule overrun and cost escalation percentages of highway projects using fuzzy approach
Authors: Abu El-Maaty Ahmed Ebrahim , El-Kholy Amr M. , Akal Ahmed Yousry 
Published: August 2017

Purpose
Modeling represents the art of translating problems from an application area into tractable mathematical formulations whose theoretical and numerical analysis provides insight, answers and guidance useful for the originating application. The purpose of this paper is to determine the causal causes of schedule overrun and cost escalation of highway projects in Egypt in order to be used as independents variables in mathematical models for predicting the percentages of schedule overrun and cost escalation of such projects in Egypt.

Design/methodology/approach
A survey of a randomly selected samples yielded responses from 40 owners, 15 consultants and 56 contractors. The survey includes 38 schedule overrun factors and 26 cost escalation factors. The effectiveness degree of the identified factors has been identified by the triangle fuzzy approach.

Findings
The results of the survey show that “contractor’s technical staff is insufficient and ineligible to accomplish the project” is the most important cause of schedule overrun, while the major cause of cost escalation is inadequate preparation of the project concerning planning and execution.

Originality/value
The main contribution of this study is predicting the percentages of schedule overrun and cost escalation of highway projects in Egypt. Through the application of the linear regression analysis method and statistical fuzzy theory, four predictive models have been developed and it has been noted that the linear regression-based model shows prediction accuracy better than statistical fuzzy-based model in predicting percentages of schedule overrun and cost escalation.
The professionals’ perspective on the causes of project delay in the construction industry
Authors: Agyekum-Mensah George , Knight Andrew David 
Published: August 2017

PurposeConstruction project delays are described as a universal problem, which has led to many empirical studies. However, most of these studies were based on the rankings by respondents, and they were rarely verified. Therefore, the purpose of this paper is to explore professional perspectives on the causes of delay in the construction industry, where there has been little explicit consideration on this subject in recent decades.Design/methodology/approachA critical literature review and a qualitative approach was considered for a deeper and fresh understanding of the causes of delays, rather than recycling the existing themes and the risk of a statistically biased approach. A total of 41 interviews were undertaken which included the London Olympic 2012 project team.FindingsIn all, 32 themes were identified, which were categorised into 15 categories of causes of delay in the construction projects. Almost two-thirds of the main themes are not ranked top 15 causes of delay. These include knowledge and competence shortage, poor commercial decisions, unnecessary health and safety restrictions, poor risk management and poor space and logistics management.Research limitations/implicationsDue to the qualitative nature of the study, the findings might not be considered as representative.Practical implicationsThe findings provide consideration of the causes of delay in the construction industry as seen by practitioners, which should provide guidance to enhance performance.Originality/valueThe study contributes to the better understanding of the causes of delays by using qualitative research strategy which is limited in the construction management literature. This study is an empirical investigation into the causes of delay in the twenty-first century and it represents an important edition to the body of knowledge within the subject area.
Drivers of green supply chain initiatives and performance
Authors: Huang Yi-Chun , Huang Chih-Hsuan , Yang Min-Li 
Published: August 2017

Purpose
The purpose of this paper is to explore how internal and external factors simultaneously drive firms to adopt green supply chain (GSC) initiatives and to construct a comprehensive research model by drawing upon institutional theory, stewardship theory, and view of performance.

Design/methodology/approach
The data collected from 380 manufacturers in the electrical and electronics industries in Taiwan were analyzed via structural equation modeling and bootstrapping.

Findings
First, institutional pressures affect the GSC initiatives of firms. Second, institutional pressures influence the environmental stewardship behaviors (ESBs) of managers. Third, the ESBs of managers affect the GSC initiatives of firms. Fourth, the GSC initiatives of firms influence their environmental performance, economic performance, and competitiveness. Fifth, the bootstrapping results reveal that institutional pressures indirectly affect the GSC initiatives of firms through the ESBs of managers.

Research limitations/implications
Environmental sustainability has intensified the need for firms to develop a corporate culture. Future research can investigate the relationship among the institutional pressures, greening corporate culture, and GSC initiatives of firms.

Practical implications
Those managers facing institutional pressures must continually focus on the effects of external factors on the GSC initiatives of their firms. They must also increase their commitment and support to such initiatives to attain favorable levels of environmental performance, economic performance, and competitiveness.

Originality/value
This study integrates four streams of literature on institutional theory, stewardship theory, GSC initiatives, and view of performance. Apart from analyzing field- and organization-level data simultaneously, this paper is also the first to demonstrate the relationships among institutional pressures, ESBs of managers, GSC initiatives, and firm performance.
Application of Gini, Theil and concentration indices for assessing water use inequality
Authors: Malakar Krishna , Mishra Trupti 
Published: August 2017

Purpose
The purpose of this paper is to propose the application of Gini, Theil and concentration indices for measuring inequality in water usage.

Design/methodology/approach
Gini coefficients and Theil indices have been used to estimate the overall inequality in domestic water use in a sample of 30 countries around the world. Along with Theil’s L (unweighted) index, liters per capita per day and gross national income weighted Theil index have also been estimated. Theil indices have been further disintegrated into within- and between-group inequalities. Concentration curve is also constructed to study the inequality in water use in accordance to the countries’ economic standing.

Findings
Domestic water use is high among the well-off countries considered in the study. Also, the Theil indices indicate that between group inequality contributes more to the overall inequality. It is observed that Theil indices, which consider only per capita water usage and can be decomposed, give a better insight into the existing inequality.

Practical implications
Different approaches were used to quantify inequality. The choice of index depends on the context of the study. The proposed approaches can contribute to planning of sustainable water management and development policies.

Originality/value
There is a dearth of metrics for quantifying inequality in water access or use. The study presents the application of indices, widely used in quantifying inequality in access to other resources such as income and energy, in assessing water inequality.
Endogenous evolution of patriarchal clan system in ancient China
Authors: Deng Feng 
Published: August 2017

Purpose
The purpose of this paper is to analyze long-term institutional causes and consequences of preference falsification by studying the evolution of China’s patriarchal clan system.

Design/methodology/approach
The historic study shows that although the clan system was abolished in the Qin dynasty, it re-emerged among high-standing families in the Han dynasty and spread to common people after the Tang dynasty.

Findings
The author submits that the clan system was an institutional response to the preference falsification problem that arose due to the dictatorial political institutions first established in the Qin dynasty. It helped people to take collective action by themselves and also opened a back door to influence government decisions. A piece of clear evidence is the co-evolution of the clan system and government personnel system.

Social implications
In this sense, the clan system probably also helped to prolong the political institutions for 2,000 years.

Originality/value
This is the first institutional study on the clan system in China.
What does materiality mean to integrated reporting preparers? An empirical exploration
Authors: Lai Alessandro , Melloni Gaia , Stacchezzini Riccardo 
Published: August 2017

PurposeThis paper aims to understand how the principle of materiality gets implemented in integrated reporting (IR) contexts.Design/methodology/approachDrawing on an interpretation of materiality as a social construction, this research explores the meaning that practitioners attach to the principle during their implementation of it. Following an existing framework for exploring materiality in corporate reporting, this study investigates the meaning by focusing on who participates in determining IR materiality and to whom the IR is addressed. This analysis benefits from in-depth interviews with persons involved in the preparation of IR for a firm that pioneered this form of reporting.FindingsIn IR preparers’ view, the meaning of materiality corresponds with the company strategy: The IR describes strategic priorities and related actions and results. Capital providers are the primary intended addressees of the material information. Although several actors engage in IR preparation, the materiality determination process is governed by a specific “IR hub” in strict collaboration with and dependence on the chief financial officer.Research limitations/implicationsIn an IR context, materiality is intimately connected to the function that preparers assign to the report.Originality/valueThis novel research opens the “black box” of the process by which materiality gets defined and then practically implemented in an IR context.
Barriers to implementing the International Integrated Reporting Framework
Authors: Dumay John , Bernardi Cristiana , Guthrie James , La Torre Matteo 
Published: August 2017

Purpose
This paper is motivated by the call for feedback by the International Integrated Reporting Council (IIRC) from all stakeholders with knowledge of the International Integrated Reporting Framework (<IRF>) and specifically of the enablers, incentives and barriers to its implementation. The paper synthesises insights from contemporary accounting research into integrated reporting (IR) as a general concept and <IR> as espoused by the IIRC in the <IRF> (IIRC, 2013). The authors specifically focus on possible barriers and emphasise the specific issues the authors feel could be rectified to advance the <IRF>, along with the areas that may potentially hinder its wider adoption and implementation.

Design/methodology/approach
The paper draws upon and synthesises academic analysis and insights provided in the IR and <IR> academic literature as well as various directives, policy and framework pronouncements.

Findings
The flexibility and lack of prescription concerning actual disclosures and metrics in the <IRF> could allow it to be used for compliance, regardless of the other benefits lauded by the IIRC. Thus the authors see forces, both external and internal, driving <IR> adoption, with one prominent example being the European Union Directive on non-financial reporting. Because of the different ways in which IR is understood and enacted, there are numerous theoretical and empirical challenges for academics. The authors paper highlights potential areas for further robust academic research and the need to contribute to <IR> policy and practice.

Research limitations/implications
The paper provides the IIRC, academics, regulators and reporting organisations with insights into current practice and the <IRF>. The authors highlight the need for further development and evidence to help inform improvements both from a policy and a practice perspective. A key limitation of the authors’ work is that the authors draw upon a synthesis of the existing literature which is still in an early stage of development.

Originality/value
The paper provides the IIRC with several insights into the current <IRF> and specifically with the enablers, incentives and barriers to its implementation. Also, it provides academic researchers with a number of important observations and an agenda upon which the authors can build their future research.