bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of PD-1 inhibitor with neoadjuvant chemotherapy in hypopharyngeal and oropharyngeal cancer
Authors: Liu Xue-Ying , Shang-guan Han-jing , Zhang Wei , Chen Shuai , Luo Xian-Yang 
Published: September 2024

ObjectiveThis study is aimed to evaluate the efficacy and safety of PD-1 inhibitors combined with neoadjuvant chemotherapy in patients with locally advanced hypopharyngeal and oropharyngeal cancer prior to surgical resection.MethodsThis retrospective analysis included 42 patients diagnosed with locally advanced hypopharyngeal and oropharyngeal cancer. The efficacy, safety, survival, and laryngeal preservation rate were evaluated.ResultsA total of 42 patients were included in this retrospective analysis, of whom 28 had hypopharyngeal cancer and 14 had oropharyngeal cancer. Of the 42 patients, 14 (33.3%) achieved a pathological complete response (PCR) at the primary site, 20 (47.6%) achieved a major pathological response (MPR), and 8 (19%) had an incomplete pathological response (IPR) at the primary lesion. A PCR at both the primary site and the neck lymph nodes was observed in 9 patients (21.4%). The laryngeal preservation rate was 92.9% (26/28) in patients with hypopharyngeal cancer. The median follow-up time was 10.5 months. The median progression-free survival (PFS) was 26.42 months (95% CI, 23.416–29.424), and the median overall survival (OS) was 27.1 months (95% CI, 24.316–29.884). The 1-year PFS rate was 83.1%, and the 1-year OS rate was 85.9%.ConclusionCombination therapy with PD-1 inhibitors and neoadjuvant chemotherapy has demonstrated superior efficacy and safety as a preoperative treatment for locally advanced hypopharyngeal and oropharyngeal cancer. Notably, this treatment regimen does not increase the risk of severe postoperative complications and has shown promising results in improving laryngeal preservation rates.
Neural correlates of prospective memory in college students with anxiety
Authors: Rice Michaela , Hansen Melissa , Thomas Michael L. , Davalos Deana 
Published: September 2024

IntroductionProspective memory (PM) is the ability to create and execute future tasks. It is comprised of two components: cue detection and intention retrieval. PM is essential for performing high-level goals, a proficiency extremely important in college populations. Anxiety is a prevalent psychological experience in college populations that may be associated with impairments in PM. The present study examined PM performance and anxiety in college students, using neurophysiology to measure the mechanism of impairment.MethodsAfter self-reporting anxiety levels, 80 participants completed an event-based, focal PM task while two event-related potentials were recorded from an electroencephalogram: the N300 to assess cue detection, and the prospective positivity to assess intention retrieval.ResultsThe results demonstrated that, when controlling for age and gender, higher state anxiety was significantly associated with lower PM accuracy (β = −0.27, p = 0.020) and lower prospective positivity amplitude (β = −0.04, p = 0.021). Lower prospective positivity amplitude was significantly associated with lower PM accuracy (β = 0.27, p = 0.015). Higher state anxiety was significantly indirectly associated with lower PM accuracy mediated by lower prospective positivity amplitude (ab = −0.11, p = 0.047).DiscussionThese findings suggest intention retrieval could be a key component in supporting PM for college students with high state anxiety.
The effect of physical activity on depression in university students: the mediating role of self-esteem and positive psychological capital
Authors: Wei Xiaolong , Lai Zhijie , Tan Zhaowen , Ou Ziyue , Feng Xueyou , Xu Guoqin , Ai Dongsheng 
Published: September 2024

ObjectiveThis study aimed to investigate the relationship between physical exercise and depression among college students, focusing on the mediating role of self-esteem and positive psychological capital.MethodsGroup psychological measurements were conducted on 579 students using various scales, including the Physical Activity Rating Scale (PARS-3), Self-Esteem Scale (SES), Positive Psychological Capital Questionnaire (PPQ), and Self-rating Depression Scale (SDS). The data was analyzed using SPSS 26.0 and bootstrap methods to test and analyze the effects.ResultsA negative correlation between physical exercise and depressive mood, with physical exercise significantly predicting college students' depressive mood. Additionally, physical exercise was found to positively predict self-esteem and positive psychological capital, both of which are negatively predictive of depressive mood. Self-esteem and positive psychological capital were identified as significant mediators between physical exercise and depressive mood, with three mediating paths: physical exercise, self-esteem, and depressed mood (Path 1), exhibited an indirect effect of 0.017, with the bootstrap 95% confidence interval excluding 0 (LLCI = −0.051, ULCI = −0.004) and accounting for 8.30% of the total effect. Physical exercise, positive psychological capital, and depression emotion (Path 2), had an indirect effect of 0.049, with the bootstrap 95% confidence interval also not containing 0 (LLCI = −0.088, ULCI = −0.011) and contributing to 23.90% of the total effect. Physical exercise, self-esteem, positive psychological capital, depressed mood (Path 3), demonstrated an indirect effect of 0.006, with the bootstrap 95% confidence interval excluding 0 (LLCI = −0.011, ULCI = −0.001) and representing 2.90% of the total effect.ConclusionPhysical exercise negatively predicts depressive mood among college students and has a mediating effect through self-esteem and positive psychological capital, creating a chain-like impact on their depressive symptoms.
Tapestry of postnatal emotional disorders: exploring the interplay of anxiety and depressive disorders and their associated risk factors in Sudanese women
Authors: Osman Abdelgadir H. , Osman Abdelaziz , Osman Ibtihal A. , Hagar Taisir 
Published: September 2024

BackgroundThis research aims to unravel the prevalence of postnatal emotional disorders with a focus on how postnatal anxiety remained under-estimated and often embroiled in postnatal depression.MethodsOut of 600 postnatal women invited to take part in this study from two prominent primary care clinics in Khartoum, 468 women agreed to participate in this study. Three questionnaires were utilized in this study, a Personal Information Questionnaire (PIQ), Hospital Anxiety and Depression Scale (HADS), and Beck depression Inventory (BDI). Multiple linear regression analysis applied to gauge risk factors with postnatal anxiety and depression.ResultsMore than half (52.50%) of women showed evidence of both anxiety and depression using HADS, while only (20.9%) of cases were detected by BDI, showing evidence of moderate depressive disorder. A substantial proportion (28.4%) showed high levels of comorbidity of anxiety and depression in the category of moderate to severe symptoms. Main risks factors for postnatal disorders were past psychiatric illness (β = 0.25, p = 0.001), a family history of psychiatric illness (β = 0.15, p = 0.002), and stress due to the number of children (β = 0.32, p = 0.001).ConclusionThis study advances our understanding of postnatal emotional disorders, particularly highlighting the prevalence as well as correlates of postpartum anxiety. More importantly, this study highlights the importance of routine screen for emotional distress in postnatal women.
Clinical management of a ruptured intracranial aneurysm
Authors: Trakolis Leonidas , Petridis Athanasios K. 
Published: September 2024

BackgroundIntracranial hemorrhage due to a ruptured aneurysm is one of the most serious neurosurgical emergencies. The patient mostly presents with severe headaches and neurological deterioration. A rapid diagnosis and an interdisciplinary approach play a major role in the fate of these patients. The treatment can vary from endovascular to surgical and must be carefully and individually planned. Neurovascular expertise and an interdisciplinary approach are of vital importance and obligatory for the best possible outcome.MethodsIn this narrative review, we scrutinize the current literature and discuss the actual data and guidelines in order to emphasize the importance of the interdisciplinary expertise and approach in patients with ruptured intracranial aneurysm.ResultsThe current approach to patients with ruptured aneurysm is inhomogeneous and often ineffective due to internal disputes between different disciplines. Although there is plenty of literature and hard evidence to “show the way,” many still choose to base their decisions on personal experience or opinion.ConclusionsEvery ruptured brain aneurysm should be approached in an interdisciplinary manor and treated according to the current evidence and guidelines.
SARS-CoV-2 Quarantine Mandated by Contact Tracing: Burden and Infection Rate Among Close Contacts in Zurich, Switzerland, 2020–2021
Authors: Aschmann Hélène Eloise , Domenghino Anja , Jung Ruedi , Ballouz Tala , Menges Dominik , Fehr Jan , Puhan Milo Alan 
Published: September 2024

ObjectivesBefore vaccines and effective treatments were available, quarantine of close contacts was important to limit the spread of SARS-CoV-2. To evaluate potential benefits and harms of quarantine, we aimed to estimate infection rates and describe experiences and mental health among persons in mandated quarantine during the early SARS-CoV-2 pandemic.MethodsWe invited adults in mandated quarantine after an exposure to SARS-CoV-2 identified through contact tracing of the Canton of Zurich, Switzerland, between August 2020 and January 2021. Participants completed two questionnaires and received up to two SARS-CoV-2 polymerase chain reaction tests, during and at the end of quarantine.ResultsAmong 395 participants, quarantine duration ranged from 2 to 20 days. By day 11 since the last contact, 11.1% [95% CI 8.4%–14.7%] were infected with SARS-CoV-2. The proportion of participants with symptoms of depression doubled from 9.3% before quarantine to 18.9% during quarantine, and 12.1% reported quarantine was very or extremely difficult.ConclusionAlthough quarantine was only moderately burdensome for most participants, some experienced significant difficulties and burden. Policymakers need to balance infection control with potential harms placed on individuals.
Effect of Additional Roles Reimbursement Scheme roles on prescription patterns and patient satisfaction in England: a retrospective panel data analysis
Authors: Nicodemo Catia , Salisbury Chris , Petrou Stavros 
Published: September 2024

Background
In 2019, the Additional Roles Reimbursement Scheme (ARRS) was introduced in England as a crucial component of the government’s manifesto pledge to enhance access to general practice. The primary objective was to recruit 26 000 extra personnel through new roles into general practice.

Aim
To analyse the effects of ARRS staff on prescription rates and patient satisfaction.

Design and setting
A retrospective panel data analysis combining data from the General Workforce Minimum Dataset and NHS Digital datasets about primary care practices and their activity from 2018 to 2022. The study included data from >6000 general practices.

Method
A linear regression analysis was conducted to determine the association between ARRS staff and prescription rates and patient satisfaction, controlling for patient and practice characteristics.

Results

The results showed that ARRS roles tend to be more frequent in larger general practices, with fewer full-time GPs per patient, and with more overseas trained GPs. The use of ARRS staff was significantly associated with lower prescription rates (β = −0.52,
P
<0.001) and higher patient satisfaction (β = 3.2,
P
<0.001), after controlling for patient and practice characteristics.

Conclusion
This study suggests that the ARRS has the potential to have a positive role in primary care, notably through reduced prescription rates and improved patient satisfaction. Further research is needed to explore the long-term effects of the ARRS on primary care, including patient outcomes and healthcare costs, and the potential barriers to its implementation.
In silico modeling of reservoir-based predictive coding in biological neuronal networks on microelectrode arrays
Authors: Sato Yuya , Yamamoto Hideaki , Ishikawa Yoshitaka , Sumi Takuma , Sono Yuki , Sato Shigeo , Katori Yuichi , Hirano-Iwata Ayumi 
Published: September 2024

Abstract
Reservoir computing and predictive coding together yield a computational model for exploring how neuronal dynamics in the mammalian cortex underpin temporal signal processing. Here, we construct an in-silico model of biological neuronal networks grown on microelectrode arrays and explore their computing capabilities through a sine wave prediction task in a reservoir-based predictive coding framework. Our results show that the time interval between stimulation pulses is a critical determinant of task performance. Additionally, under a fixed feedback latency, pulse amplitude modulation is a favorable encoding scheme for input signals. These findings provide practical guidelines for future implementation of the model in biological experiments.
Magnonic noise in the parametric spin-wave pumping process
Authors: Nishiwaki Yuri , Nezu Shoki , Sekiguchi Koji 
Published: September 2024

Abstract
This study investigates magnonic noise in the context of parametric spin-wave pumping in a yttrium iron garnet waveguide. By analyzing the input power dependence of parametric spin-wave spectra, we observed spectrum broadening and the emergence of additional pumping channels. A threshold power of 99.9 mW was determined based on spin-wave voltage. To elucidate magnon dynamics beyond the threshold, magnonic noise was examined, revealing its greater sensitivity to magnon scattering compared to spin-wave voltage. The detection of four-magnon scattering and its power-dependent behavior provides further insights into magnon interactions. Our findings contribute to a deeper understanding of magnon dynamics in parametric pumping, a critical process in magnonics.
Recovery of drain-induced threshold voltage shift by positive gate bias in GaN power HEMTs with p-GaN gate
Authors: Favero D. , De Santi C. , Nardo A. , Dixit A. , Vanmeerbeek P. , Stockman A. , Tack M. , Meneghesso G. , Zanoni E. , Meneghini M. 
Published: September 2024

Abstract
We demonstrate that exposure to positive gate bias can favor a fast recovery of the threshold voltage variation induced by off-state stress, in p-GaN gate high electron mobility transistors. Two process splits were investigated, having different Schottky barriers at the metal/p-GaN junction. Results indicate that: (a) drain stress may result in significant threshold voltage increase; (b) devices with sufficiently high gate leakage current show an immediate recovery after gate turn-on, resulting in stable operation in actual applications. The contribution of leakage current is demonstrated, based on recovery experiments at different voltages and for the same rate of hole injection from the gate.
MAXIMIZE DIGITAL GAME BASED LEARNING TO TEACH ENGLISH FOR YOUNG LEARNERS: TEACHER’S VIEW
Authors: Zen Aida Fitrianah , Rinda  
Published: September 2024

Digital Game-Based Learning (DGBL) has gained significant popularity in Teaching English to Young Learners (TEYL) due to its potential to enhance student engagement and motivation. This article explores the teacher's view of the use of DGBL in TEYL. Several areas of the study such the different of conventional and digtal game for teaching EYL, lesson plan, and the use of Agenda web and duolingo as the digital platform in teaching DGBL obtained from the deepper interview. Support for future research are suggest in the conclusion.
Keywords: DGBL, TEYL, Teacher’s view
Análise Epidemiológica da AIDS no Nordeste durante o período de 2019 a 2023
Authors: Dos Santos José Vinicius , De Jesus dos Santos Leopoldino Dayane , Batista de Oliveira Neto Eclésio , Bezerra Silva Ana Beatriz , Brandão de Albuquerque Ernesto , Da Silva Valença Milones Maria Eduarda , Ferreira Duarte Kristiane , Albuquerque Oliveira Vinicius , Serejo Medeiros Pinaud Calheiros Karolinne , Inês Costa Cordeiro Karine , Rodrigues Silva Lara Silvina , Beatriz Cardoso de Albuquerque Nascimento Vitória 
Published: September 2024

Introdução: A Síndrome da Imunodeficiência Adquirida (AIDS), provocada pelo vírus da Imunodeficiência Humana (HIV), é uma doença que se desenvolve após um longo período de incubação do vírus. O HIV compromete o sistema imunológico, afetando especialmente os linfócitos CD4 +, além de monócitos e macrófagos, tornando o indivíduo mais suscetível a diversas infecções oportunistas. Objetivo: descrever o perfil epidemiológico dos casos diagnosticados de HIV/AIDS na região Nordeste durante o período de 2019 a 2023. Metodologia: estudo observacional, descritivo e retrospectivo, através do levantamento de dados epidemiológicos dos casos diagnosticados de HIV/AIDS, no Nordeste, no período de 2019 a 2023. As informações epidemiológicas e de morbidade foram obtidas no Departamento de Informática do Sistema Único de Saúde (DATASUS), na subseção do Sistema de Informações sobre Sistema de Informação de Agravos de Notificação (SINAN). Foram calculadas as frequências absolutas e relativas das variáveis aplicadas e selecionadas na aba do SINAN para elaboração do estudo: “ano de diagnóstico”, “sexo”, “faixa etária”, “Raça/Cor”, “Unidade Federativa de notificação” e “Categoria de exposição”. Resultados: Entre 2019 a 2023, foram diagnosticados 19.291 casos de AIDS no Nordeste, sendo o ano de maior incidência 2019 e o de menor incidência em 2023. Observou-se o maior número de casos no sexo masculino, indivíduos de cor parda, adultos entre 40 a 49 anos, e residentes no Estado da Bahia, sendo os heterossexuais os responsáveis pela maior parte das infecções. Conclusão: O mapeamento das características epidemiológicas da AIDS é de extrema importância para a criação e adoção de novas estratégias que visem à redução dos casos da doença no Brasil.
Management numérique comme levier du développement des entreprises modernes: Transformation, Compétitivité Digitale, Ethique, et Prise de décision data-driven.
Authors: - YENDE Raphaël Grevisse , - KALOMBO Masimango Monique-Stéphanie , - SANGUPAMBA MWILU Odette , - TSHIELA NKUNA Marie Alice , - KANKOLONGO MALULA Hélène. 
Published: September 2024

L'article intitulé « Le Management numérique comme levier du développement des entreprises modernes: Transformation, Compétitivité Digitale, Éthique, et Prise de décision data-driven », explore l'impact croissant du management numérique dans le développement des entreprises modernes. Il met en évidence comment les technologies digitales et les outils numériques révolutionnent la gestion des entreprises, facilitant leur transformation vers des modèles d'affaires plus flexibles et innovants. Le texte examine également la compétitivité digitale, soulignant l'importance pour les entreprises de s'adapter aux nouvelles réalités numériques pour rester concurrentielles sur le marché global. Par ailleurs, l'article aborde les questions éthiques liées à l'utilisation des technologies numériques, en insistant sur la nécessité d'une gestion responsable et d'une prise de décision basée sur des données fiables (data-driven). En conclusion, l'article propose des stratégies pour intégrer efficacement ces technologies tout en respectant les principes éthiques.
Navigating Indian Youth’s Identity; Impact Of Korean Media on Language learning
Authors: - Divyanshi Gaur , - Prof. Dr. Sunder Rajdeep 
Published: September 2024

The study of ‘Navigating Indian Youth’s Identity: The Impact of Korean Media on Language Learning’ to explores the complex relationship between Indian youth and the impact of Korean media on language learning. Given the increasing popularity of Korean entertainment, especially K-drama and K-pop, among Indian youth, this study aims to investigate the effect of Korean media exposure on language learning, Korean media has been an effective language learning tool among Indian adolescents, as it has increased their interest in learning Korean, provided motivation, influenced their language learning strategies, positive language learning outcomes, open up career opportunities, facilitate, especially by learning Korean language.
A combination of methods was employed, including statistical data analysis and data analysis, to accomplish the aforementioned goals.
The impact of Korean media on Indian youth has been divided into various factors such as increased interest in Korean media, especially K-pop-K dramas, which encouraged them to learn the language, though various forms of media such as subtitles, translations , and educational materials It's been simplified.
Flaring Activity for Low-mass Stars in the β Pictoris Moving Group
Authors: Ealy Jordan N. , Schlieder Joshua E. , Komacek Thaddeus D. , Gilbert Emily A. 
Published: September 2024

Abstract
Stellar flares from K and M dwarfs release panchromatic radiation characterized by a significantly higher brightness temperature (∼9–20 kK) than the star. The increased frequency of magnetic activity on young low-mass stars results in the energy released during flaring events becoming a notable contributor to the radiation environment. This study focuses on the β Pictoris moving group (βPMG; 24 ± 3 Myr) for the analysis of young low-mass star flaring rates within the framework of larger flare studies. The calibration of long-term optical flare statistics is crucial to updating flare activity–age relations and the interpretation of exoplanet atmosphere observations. Using the βPMG, we develop a modular flare-extraction pipeline sensitive to low-mass stellar flares in observations from the Transiting Exoplanet Survey Satellite (TESS). This pipeline is built to characterize the flare properties of these stars such as total energy and cumulative flare rate. Consistent with previous studies, this sample (N = 49) shows higher cumulative flare rates than early-type and old field stars by at least an order of magnitude. Fitted flare frequency distributions for both early- and late-type M dwarfs show an average slope of 1.58 ± 0.23, with earlier stars flaring with lower or similar rates to late types. A typical member in this sample has daily (∼1 day−1) flares with TESS band energies of 1032–1033 erg. The optical flare rates and energies for this group provide essential context into the coevolution of host stars and associated planets.
Updated System of S i Levels Using Fourier Transform Infrared Spectroscopy in the Range from 800 to 11,000 cm−1
Authors: Civiš S. , Kramida A. , Zanozina E. M. , Kubišta J. , Kubelík P. , Ferus M. , Chernov V. E. 
Published: September 2024

Abstract
In this study we report on high-precision laboratory measurements of transition wavenumbers for 172 atomic sulfur lines in the infrared region 800–11,000 cm−1 using Fourier transform spectroscopy techniques. Our analysis includes 96 lines that have not been previously measured in the laboratory. We also correct several sulfur energy-level measurements reported in earlier studies. These refined measurements are important for a range of scientific disciplines, such as astrophysics, atmospheric chemistry, and combustion plasma physics. We have used the combined list of all observed lines to derive a refined set of sulfur energy levels. For about half of all nonautoionizing levels, the uncertainties have been reduced by a factor between 2 and 23. From the newly measured nonpenetrating (high-l) Rydberg levels we have also obtained the first ionization energy of the S atom, IE = 83,559.170(11) cm−1, which is more accurate than the currently recommended value by 2 orders of magnitude. Our analysis has led to a significantly more accurate result than the earlier set of Ritz wavelengths with observed intensities reduced to a common uniform scale and an extended list of recommended transition probabilities.