bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Spectrum of Heatstroke in a Tertiary Care Hospital during the 2024 Delhi Heat wave Peak
Authors: Titiyal Renuka , Arora Aanchal , Ranjan Abhishek , Dhawale Yash , Margekar Shubha Laxmi , Prakash Anupam 
Published: October 2024

Abstract

Background:
Heat-related illnesses (HRIs) have a wide spectrum from relatively mild heat cramps to heatstroke in its severest form. The 2024 heat wave in Delhi, with temperatures consistently above 40°C, resulted in over 270 deaths due to heatstroke. This study examines nine cases of classical heatstroke admitted over a 24-h period to a tertiary care hospital in Delhi.

Materials and Methods:
This is a cross-sectional study of patients presenting to emergency with altered consciousness during the 24-h period just before the culmination of the 40-day long heat wave period. In the absence of alternative etiologies on the investigation, a diagnosis of classical heatstroke was entertained. The sociodemographic details, clinical features, investigations, treatment, and outcomes of nine such patients are being reported.

Results:
Common symptoms observed in the patients were hyperthermia (100%), dehydration (100%), altered sensorium (100%), vomiting (33%), and seizures (33%). Laboratory findings showed respiratory alkalosis (100%), hypokalemia (88.8%), thrombocytopenia (88.8%), and transaminitis (77.7%). Eight heatstroke patients required mechanical ventilation. Despite intensive treatment, three patients died, whereas six were discharged in stable condition.

Conclusion:
The 2024 heat wave in Delhi highlighted the severe impact of extreme heat on health. The spectrum of clinical features in classical heatstroke has been outlined. The impact of heat wave was such that even normal individuals accustomed to high-heat environments developed HRI. Early recognition and rapid cooling are crucial in managing heatstroke. Improved public awareness, healthcare infrastructure, and management protocols are essential to mitigate the effects of future heat waves.
Relationship between Prices and Quality of Essential Medicines from Different Manufacturers Collected in Cameroon, the Democratic Republic of the Congo, and Nigeria
Authors: Gabel Julia , _ _ , Martus Peter , Heide Lutz 
Published: October 2024

ABSTRACT.
Achieving universal access to affordable medicines and at the same time ensuring the quality of medicines presents a challenge, especially in low- and middle-income countries. Here, the relationship between medicine prices and medicine quality was investigated in three African countries. From different types of health facilities and medicine vendors, 711 samples of 18 different essential medicines were purchased and analyzed for quality (assay and dissolution) according to the United States Pharmacopeia. Without exception, all originator brand medicines and all SRA generics (generic medicines manufactured in countries with stringent regulatory authorities [SRAs]) complied with pharmacopeial specifications. In contrast, 21.1% of the non-SRA generics (manufactured in countries without SRAs) were substandard. The median prices of originator brands and SRA generics were three times and two times higher than those of non-SRA generics, respectively. Within the non-SRA generics, no positive correlation was observed between medicine quality and medicine price. Medicines manufactured in India, China, or African countries showed similar quality and similar prices. Only a single WHO-prequalified medicine sample was found among the 711 samples. Non-SRA generic medicines produced by manufacturers for which WHO had published Public Inspection Reports showed a significantly lower rate of substandard medicines (7.3%) and, at the same time, significantly lower prices (by 33%) than other non-SRA generics. Falsified medicines (total 2.0%) were found among all categories of medicines and had prices similar to those of non-SRA generics. Our findings indicate that adequate quality assurance does not necessarily imply an increase in medicine prices.
Effectiveness of Antileishmanial Treatments in Three Endemic Areas of Colombia: A Community-Based Cohort Study
Authors: Castro María del Mar , Del Castillo Alejandra María , Castillo Ruth Mabel , Cossio Alexandra , Castaño Grajales Patricia , Gutiérrez Yeison , Alexander Neal 
Published: October 2024

ABSTRACT.
The effectiveness of treatment of cutaneous leishmaniasis (CL) in rural settings remains underexplored. This study assessed the effectiveness of standard antileishmanial treatments using a community-based approach supported by mobile health (mHealth) in three rural areas of Colombia. From January 2018 to September 2021, we assessed treatment outcomes, adherence, and adverse drug reactions in CL patients, with the support of the Guaral+ST app. Treatment decisions were made by providers at health facilities at each site in accordance with national guidelines, whereas treatment follow-up and presumptive case identification were made by trained community leaders and health agents at the community level. In total, 231 participants received antileishmanial treatment (63 received miltefosine, 110 meglumine antimoniate, and 58 pentamidine). Disease presentation was mild (median number of lesions = 1, interquartile range [IQR]: 1–2) and of short duration (1.5 months, IQR: 1–3). The strategy yielded information on the therapeutic outcomes in 81% of study participants. Effectiveness, measured as the proportion of cure at 90 to 180 days, was 86.3% (95% CI: 73.3–93.48) for miltefosine; 77.6% (67.5–85.3) for meglumine antimoniate, and 73.1% (59.0–83.6) for pentamidine. The effectiveness of pentamidine in children ≤10 years old was 79.4% (61.6–90.3). This is one of the few reports of effectiveness of pentamidine in children with prospective data collection in the Americas. Adverse drug reactions occurred in 32% of patients, most frequently with meglumine antimoniate. Our findings demonstrate that standard antileishmanial treatments are effective in rural areas where the disease is endemic and that mHealth has a pivotal role in improving patient follow-up and data collection on therapeutic outcomes.
Scorpion Envenoming as an Emerging Public Health Problem in Paraguay, Bolivia, and Midwest Brazil: Involvement of Tityus confluens and the Need for a Panregional Evaluation of Available Antivenoms
Authors: Borges Adolfo , Rojas de Arias Antonieta , Montaño Ana María , de Souza Cláudio Mauricio V. 
Published: October 2024

ABSTRACT.
This contribution highlights the emergence of a newly endemic region for scorpion envenoming in South America, covering eastern Bolivia, Paraguay, and the midwestern Brazilian states of Mato Grosso and Mato Grosso do Sul. These areas have not historically been known to harbor life-threatening scorpion species. Tityus confluens, a parthenogenetic species of medical significance in Argentina, has been identified in severe and lethal human cases in Bolivia and Paraguay. Given that the clinical use of scorpion antivenom preparations in the region has often lacked preclinical data and considering the significant burden of scorpion envenoming, we propose a panregional evaluation of available anti-Tityus antivenoms. This evaluation, along with interdisciplinary efforts at a multinational scale to control scorpionism, aims to determine their true neutralization capacity and potential clinical efficacy against known culprits in the Southern Cone of South America and other regions endemic for scorpion envenoming on the continent.
Sistem Informasi Penjualan Usaha Mikro Kecil Menengah Di Kota Palangka Raya Berbasis Website
Authors: Vianus Rezaski Yoan , Sari Nova Noor Kamala , Geges Septian 
Published: October 2024

Usaha mikro, kecil dan menengah (UMKM) merupakan pelaku bisnis yang bergerak pada berbagai bidang usaha, yang menyentuh kepentingan masyarakat. Kemunculan sektor Usaha Mikro, Kecil, Menengah (UMKM) membawa pengaruh positif pada perekonomian. Pengolahan data sudah cukup baik akan tetapi belum terkomputerisasi secara digital sehingga pembeli harus melakukan transaksi jual-beli secara langsung. Berdasarkan hal tersebut, dibuatlah Sistem Informasi Penjualan Usaha Mikro Kecil Menengah Di Kota Palangka Raya Berbasis Website. Metodologi yang digunakan dalam aplikasi Sistem Informasi Penjualan Usaha Mikro Kecil Menengah Di Kota Palangka Raya ini adalah waterfall. Pengujian menggunakan metode blackbox.
Hasil penelitian ini adalah sebuah aplikasi Sistem Informasi Penjualan Usaha Mikro Kecil Menengah Di Kota Palangka Raya Berbasis Website memfasilitasi pemesan dalam mendapatkan informasi seperti informasi lokasi, informasi penjualan berbagai barang dan jasa yang ditawarkan oleh pengusaha UMKM serta dapat melakukan proses transaksi di aplikasi E Commerce, sehingga mempermudah penjual dan pelanggan masyarakat luas dalam penjualan dan pembelian produk secara online. Website ini menggunakan API (Application Programming Interface) yaitu Payment Gateaway Midtrans dan Biteship API. Dari pengujian yang dilakukan menggunakan blackbox, sistem serta fungsional fitur-fitur berjalan sesuai harapan.
Analisa Kepuasan Masyarakat Terhadap Puskesmas Pahandut Menggunakan Metode Servqual
Authors: Amrullah Rizaldi , Putra Putu Bagus A.A. , Sari Nova Noor Kamala 
Published: October 2024

Puskesmas adalah fasilitas pelayanan kesehatan yang menyelenggarakan upaya kesehatan masyarakat dan upaya kesehatan perorangan tingkat pertama. Pada proses penilaian kepuasan pasien di Puskesmas Pahandut saat ini, masih menggunakan kotak saran sebagai penghubung antara pasien dan para pelayanan kesehatan. Oleh karena itu, perlu dilakukan perancangan sebuah aplikasi yang diharapkan dapat memfasilitasi Puskesmas Pahandut dalam proses penilaian kepuasan terhadap kinerja yang ada dengan Metode Servqual. Metodologi yang digunakan dalam aplikasi Analisa Kepuasan Masyarakat Terhadap Puskesmas Pahandut ini adalah waterfall. Pengujian menggunakan metode blackbox.
Hasil penelitian ini adalah sebuah analisis data yang tersedia, dapat dilihat bahwa setiap poli mempunyai nilai gap cenderung ke negative, misalkan poli pemeriksaan umum gap terendahnya yaitu -1,84 dan poli kia/kb nilai gap terendahnya adalah -2,8 , yang artinya bahwa harapan dari responden cenderung lebih besar dari nilai sesungguhnya, maka dari itu dapat disimpulkan tampaknya terdapat beberapa kelemahan yang perlu segera diperbaiki dalam layanan kesehatan.
Extensive Remedial in Factoring Polynomials on STEM Learners: An Action Research
Authors: Bernal Jr. Hernando L. , Gumaru Renz Chester R. 
Published: October 2024

There is a widely belief that high school students find it difficult to factor various kind of polynomials. Different ways of factoring polynomials are also highly considered in this action research. This paper chose grade 11 Science Technology Engineering and Mathematics students as respondents of the study. The study will use Extensive Remedial as the intervention for the problem. Results and Interpretation are obtained by using various appropriate statistical formulas like t-test and standard deviation. The researchers conducted this action research to verify if an extensive remedial will have a positive impact on improving the students’ ability to factor different set of polynomials
Linfohistiocitosis hemofagocitica secundaria a infección por el virus de Epstein BARR: Reporte de caso
Authors: Bravo Bazurto María Elizabeth 
Published: October 2024

Introducción: La linfohisticiocitosis hemofagocitica es un síndrome heterogéneo poco frecuente y de mortalidad elevada caracterizado por inflamación desproporcionada e incontrolable debido a la activación del sistema inmunológico (macrófagos y linfocitos activados) por causas primarias y secundarias como la infección por el virus de epstein BARR. Se caracteriza por fiebre, esplenomegalia, elevación de biomarcadores de inflamación. El virus de epstein BARR es la causa infecciosa más frecuente. Para el diagnostico se debe tener alta sospecha clínica y cumplir 5 de los 8 criterios de la histiocyte society hlh 2004. El inicio temprano de la terapia inmunosupresora y mielosupresora mejora la tasa de supervivencia. se presenta el caso de una lactante menor con cuadro clínico de fiebre, diarrea, somnolencia que incurrió con insuficiencia respiratoria aguda, al examen físico presentaba hepatoesplenomegalia. Exámenes de laboratorio con marcadores inflamatorios y enzimas hepáticas elevados, pcr para virus de epsteina barr con más de 7 millones de copias detectadas y mielograma demostró hipocelularidad medular con hemofagocitosis evidente. Objetivo: Instruir a los médicos pediatras sobre la identificación de características clínicas, diagnóstico precoz y tratamiento adecuado de esta patología poco conocida. Materiales y métodos: Se recolectó información sobre el caso en el sistema de médico en el hospital de niños dr. roberto gilbert elizalde y revisión de la literatura científica. Resultados: A pesar del tratamiento administrado según el protocolo hlh 94, no hubo respuesta favorable con desenlace fatal. Conclusión: La linfohistiocitosis hemofagocítica es un síndrome hiperinflamartorio poco frecuente con clínica inespecífica, que sin un diagnóstico y manejo oportuno presenta alta mortalidad.
A Review to Illustrate the Concept of Krimi in Ayurveda
Authors: Huddar Shreedevi , Ullagedi N S , Vaishalee Kamble 
Published: October 2024

Background: Knowledge of Krimi and its description in Vedas and Ayurvedic Samhitas is very unique and different from the concept of worm in modern medical science. Krimi is a broad terminology in ancient Indian science which encompasses various types of helminths, microorganisms such as bacteria, viruses, fungi, and protozoa causing a large variety of diseases. Materials and Methods: A narrative review was conducted and result was presented under the result. Result and Discussion: Krimi Roga is one among the various diseases which must be paid prime attention in terms of Ayurveda management. Drugs and formulations from herbal sources play key role in management of these helminthic and parasitic infections. A majority of patients being from pediatric age segment, the knowledge of Krimi Roga management may bring a boon to pediatric ailments. Conclusion: Ayurveda believes in Prakriti (specific body constitution of the individual), if we can change the internal environment of the intestine (Kostha) through Apkarshana, Prakriti Vighata and Nidana parivarjana using appropriate drugs as well as enhancing the strength of Agni; then, affinity towards production and multiplication of Krimi may be arrested and hence, the ailments can be treated. Krimi is a condition, affecting all age groups, but children have always been at risk due to their playful activities and lack of maintenance of adequate personal hygiene. Once infected, the entire family may eventually get affected from the infected children.[1] If we consider Drishya Krimi as worm infestation, In India, more than 200 million children are infected on an average with roundworm, hookworm, etc. In Ayurveda, several causes (nidanas) have been mentioned for development of Krimi (microbes/worms) in human body like Ajirna (indigestion in GIT), Adhyashana (eating even when the previous meal has not been digested), Asatmyaahara, Virudhasana, Malinasana (incompatible foods or unhygienic meal habit), Avyayam (sedentary lifestyle), Diwaswapna (sleeping during the daytime), Guru (heavy), Atisnigdha (excessively fatty diet), Atisheet Ahara-Vihara (cold
Knowledge & Attitude among Parents of Children with Bronchial Asthma whom Attending Iraq Pediatric Hospital
Authors: Al Quraini Abrar Naser Hasan Ali 
Published: October 2024

Background: Asthma is a prevalent chronic condition in pediatric populations. The rising incidence, morbidity, and mortality rates associated with asthma have heightened public health concerns. Pediatric asthma imposes a substantial burden on affected children, their families, and the broader community. Effective asthma management encompasses regular monitoring, symptom control, and the prevention of exacerbations. Objectives: The study aimed to document the knowledge, attitudes of parents of children with asthma and to identify the factors associated with parent knowledge and attitude. Method: A study was conducted involving 205 parents of children under five years old with asthma, who attended the Karbala Pediatric Hospital between February 15 and May 15, 2023. A specially designed questionnaire was utilized, comprising three sections: the first section addressed socio demographic information of both children and parents, the second section evaluated the parents' knowledge, and the third section assessed the parents' attitudes. Responses were scored with one point for correct answers and zero points for incorrect or "I don't know" answers. Statistical analyses, including the Student's T-test, ANOVA, and linear regression, were employed to identify factors associated with parental knowledge. Results: The results indicated that the majority of participants were mothers, with a mean age of 29 years, and the majority of asthmatic children were male (69.3%), with a mean age of 34.4 months. It was found that 48.8% of participants had a poor knowledge score, while 61% had a poor attitude score. Key factors influencing knowledge scores included the family’s place of residence, the child’s birth order, the duration of the disease, the age at disease onset, the participant’s age, and the mother's educational level. Conclusion: Overall, the parents demonstrated limited knowledge and unfavorable attitudes regarding childhood asthma. Enhancing their understanding and attitudes could potentially lead to improved management practices among parents of children with asthma.
Overview of Governance and Rampant Corruption in Land Administration in Bangladesh
Authors: Chowdory Mohammad Moin Uddin 
Published: October 2024

This study focuses on the governance and corruption in the land management system of Bangladesh and the effect of these factors on the tenure security of land and the country’s economic growth. This study used a quantitative research design. The research outcomes show that corruption is systematic in all levels of land management, thus eroding the security of tenure, and worsening social inequalities. The new governance reforms have also been implemented to curb corruption; however, these changes’ impact has been rather poor. In light of the findings of the study, there is a well-established need for systematic reform to improve the situation in Bangladesh through digitization of land records, better transparency, and higher accountability in the land administration sector. The investigation presented in this research adds to the discussion of governance and development and offers practical policy suggestions that relate to fighting corruption and enhancing the efficient utilization of Bangladeshi land.
Investigation of the Effectiveness of TRIZ Invention for Enhancing Design Creativity in High School Students in China: The role played by teacher self-efficacy
Authors: Dongna Liu , SHARUDIN@SHARADDIN SHARUL AZIM BIN 
Published: October 2024

Purpose – The purpose of this study was to evaluate the effectiveness of creative problem solving methodologies, such as TRIZ, in boosting design creativity in high school students in China, considering the role of the teachers’ self-efficacy in implementing such interventions. Design/methodology/approach –The study employs an experimental or quantitative research methodology to systematically assess the efficacy of the TRIZ intervention and explore the factors characterizing the integration of creative applied methodologies into educational practice. Results demonstrate a significant increase in students' design creativity following the TRIZ intervention, as evidenced by pre- and post-intervention assessments. Findings – The study reveals a strong correlation between teacher self-efficacy and the effective implementation of TRIZ. Teachers with high self-efficacy in teaching TRIZ were more likely to create learning environments that enhanced student creativity, thereby maximizing the intervention's impact. Conversely, teachers with lower self-efficacy showed resistance to incorporating TRIZ into their teaching practices, potentially compromising its effectiveness. This study demonstrates the significant potential of the TRIZ methodology for enhancing the design creativity of high school students in China. Research limitations– The study has limitations because of its geographical concentration on the Chinese students and teachers. Future research could look into additional regions to validate this notion. Practical implications – For effective implementation of TRIZ, teachers should prepare their teaching material that incorporates TRIZ principles systematically.
La atención educativa a personas con discapacidad intelectual desde la comunidad
Authors: Galvez Jimenez Beatriz de la Caridad , Pérez Rodríguez Lismay , Pérez Chávez Diana Estela 
Published: October 2024

En Cuba la atención educativa a los educandos con discapacidad intelectual constituye una prioridad que deben asumir los profesionales implicados en su educación, así como los miembros de su familia y otros agentes educativos. El objetivo de esta investigación se expresa en caracterizar la atención educativa a las personas con discapacidad intelectual de un Consejo Popular de la ciudad de Santa Clara, Provincia de Villa Clara a partir de su vínculo con los proyectos comunitarios como parte del desarrollo de la extensión universitaria con el fin de enriquecer la relación universidad-sociedad. La metodología en esta investigación es de enfoque cualitativo con un alcance descriptivo, se seleccionaron como muestra siguiendo el criterio no probabilístico intencional 17 personas en situación de discapacidad. La intención se expresa en conocer la realidad de este proceso a partir de la aplicación de métodos empíricos y la utilización de métodos teóricos para su comprensión y fundamentación del tema. Los resultados revelaron las potencialidades y necesidades que caracterizan esta atención educativa en el contexto comunitario, la necesidad de lograr consolidar el vínculo universidad-sociedad y nuevas vías para lograrlo.