bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unter großen Dächern – Einblicke in die Welt der Shopping Malls
Authors: Möller Eberhard 
Published: September 2016

AbstractOhne die Errungenschaften des modernen Eisen‐ und Stahlbaus wären sie kaum denkbar, die Konsumtempel des 20. und 21. Jahrhunderts. Das Architekturmuseum der Technischen Universität München widmet der WOLRD OF MALLS nun eine Ausstellung mit dem Untertitel “Architekturen des Konsums”. Bis zum 16. Oktober 2016 werden 23 wegweisende Mall‐Projekte aus aller Welt in der Münchner Pinakothek der Moderne gezeigt und erläutert.Under large roofs – Insights into the world of shopping malls. Without the achievements of modern iron and steel structures the consumer temples of the 20th and 21st century are hardly conceivable. The Architekturmuseum of the Technische Universität München now dedicates an exhibition to the WOLRD OF MALLS subtitled “architectures of consumption”. Until October 16, 2016 the number of 23 pioneering mall‐projects from all over the world is shown and explained in the Munich Pinakothek der Moderne.
Bivariate return periods and their importance for flood peak and volume estimation
Authors: Brunner Manuela Irene , Seibert Jan , Favre Anne‐Catherine 
Published: September 2016

Estimates of flood event magnitudes with a certain return period are required for the design of hydraulic structures. While the return period is clearly defined in a univariate context, its definition is more challenging when the problem at hand requires considering the dependence between two or more variables in a multivariate framework. Several ways of defining a multivariate return period have been proposed in the literature, which all rely on different probability concepts. Definitions use the conditional probability, the joint probability, or can be based on the Kendall's distribution or survival function. In this study, we give a comprehensive overview on the tools that are available to define a return period in a multivariate context. We especially address engineers, practitioners, and people who are new to the topic and provide them with an accessible introduction to the topic. We outline the theoretical background that is needed when one is in a multivariate setting and present the reader with different definitions for a bivariate return period. Here, we focus on flood events and the different probability concepts are explained with a pedagogical, illustrative example of a flood event characterized by the two variables peak discharge and flood volume. The choice of the return period has an important effect on the magnitude of the design variable quantiles, which is illustrated with a case study in Switzerland. However, this choice is not arbitrary and depends on the problem at hand. WIREs Water 2016, 3:819–833. doi: 10.1002/wat2.1173This article is categorized under:

Engineering Water > Methods
Engineering Water > Planning Water
Science of Water > Water Extremes
Phase I study of NK105, a nanomicellar paclitaxel formulation, administered on a weekly schedule in patients with solid tumors
Authors: Mukai Hirofumi , Kato Ken , Esaki Taito , Ohsumi Shouzou , Hozomi Yasuo , Matsubara Nobuaki , Hamaguchi Tetsuya , Matsumura Yasuhiro , Goda Rika , Hirai Takayuki , Nambu Yoshihiro 
Published: September 2016

AbstractPrevious studies have established the rationale for NK105, a nanomicellar formulation of paclitaxel, administered every 3 weeks. The aim of this phase I study was to determine the recommended dose and pharmacokinetics of weekly administered NK105. NK105 was administered by a 30-min infusion once weekly for three consecutive weeks in each 4-week cycle. In the dose-escalation phase, three to seven patients with solid tumors were enrolled to each of the four dose levels (50–100 mg/m2; n = 16). At a dose level of 100 mg/m2, predefined dose-limiting toxicity (DLT) manifested in only one out of six evaluable patients, whereas a dose delay due to neutropenia during the first course occurred two patients. None of the three patients given 80 mg/m2 had a dose reduction, while a dose delay occurred in two. NK105 exhibited linear pharmacokinetics at doses of 50–100 mg/m2, and approximately 5 % of total paclitaxel was released from micelles. Thus, the recommended dose was set at 80 mg/m2, and an additional 10 advanced breast cancer (ABC) patients were given this dose in the dose-expansion phase. DLT manifested in two patients, and grade ≥ 3 neutropenia was found in eight patients. Among the nine patients who completed the first cycle, four had a dose reduction, mostly because of neutropenia. Of the 10 patients, six achieved partial response (PR), and four achieved stable disease (SD) status. Overall, weekly NK105 was well tolerated and had a desirable antitumor activity profile. Further investigations of NK105 in ABC patients are currently underway.
Plutarch's Politics
Authors: Liebert Hugh 
Published: September 2016

Plutarch&apos;s Lives were once treasured. Today they are studied by classicists, known vaguely, if at all, by the educated public, and are virtually unknown to students of ancient political thought. The central claim of this book is that Plutarch shows how the political form of the city can satisfy an individual&apos;s desire for honor, even under the horizon of empire. Plutarch&apos;s argument turns on the difference between Sparta and Rome. Both cities stimulated their citizens&apos; desire for honor, but Sparta remained a city by linking honor to what could be seen first-hand, whereas Rome became an empire by liberating honor from the shackles of the visible. Even under the rule of a distant power, however, allegiances and political actions tied to the visible world of the city remained. By resurrecting statesmen who thrived in autonomous cities, Plutarch hoped to rekindle some sense of the city&apos;s enduring appeal.
INFLUENCES OF SHADING AND FERTILIZATION ON ON-FARM YIELDS OF COCOA IN GHANA
Authors: ASARE RICHARD , ASARE REBECCA ASHLEY , ASANTE WINSTON ADAMS , MARKUSSEN BO , RÆBILD ANDERS 
Published: September 2016

SUMMARYMost cocoa farms in Ghana are cultivated in complex agroforest systems, with plant growth and cocoa productivity being affected. The objective of this study was to investigate how shade trees affect cocoa yield, temperature and soil nutrients in low-input cocoa systems. Establishing plots on 24 farms in four locations (districts) in Ghana, we assessed the influence of varying canopy cover and fertilization on cocoa yields. Results showed no relationship between canopy cover and cocoa yields in the light crop season (February to August). For the main crop season (September to January), there was an interaction between shade and yields: Yields were higher on no-shade plots than on shaded plots in two districts, whilst there were no differences at the two other districts possibly due to differences in precipitation and soil nutrient status. On the other hand, there was a positive effect of increased canopy cover on yields within the shaded plots. Soil nutrient analyses revealed no significant differences between shaded and no-shade plots and adequate levels of N, K+, Fe2+, Cu2+and Zn2+were recorded. However, soil contents of P, C, Mg2+and Ca2+were below recommended values. Peak temperatures recorded in the cocoa canopies were above the recommended range for this species. Although shade trees had a slight modifying effect on peak temperatures, the magnitude appeared too small to have any practical effects.
THE YIELD GAP: CLOSING THE GAP BY WIDENING THE APPROACH
Authors: SNYDER KATHERINE A. , MITHTHAPALA SRIYANIE , SOMMER ROLF , BRASLOW JULIET 
Published: September 2016

SUMMARYThe yield gap has arisen again as a focus for agricultural research to ensure food security and economic growth for farmers around the world. To examine this renewed interest, we carried out a review of key literature in the field of yield gap analysis to identify important gaps in research and analysis. In so doing, both the complexities in yield gap studies emerged along with some significant omissions. Much of the literature and research on the yield gap has been framed by larger concerns and initiatives to raise agricultural productivity. This focus has led to an emphasis on technical solutions such as crop breeding, fertilizer application and other methods to increase production. However, this concentration on the technical usually ignores the wider social, economic and political context that shapes farmer decision-making about agricultural production. This context can either discourage or enable farmers to close their yield gap. Additionally, the impact of increased agricultural production through certain technical solutions also often overlooks the wider impact on the landscape and the ecosystem services which underpin agricultural production and livelihoods. We argue that increasing agricultural productivity, and closing the yield gap, must be addressed with this broader approach.
SOIL QUALITY INDICATORS AND CROP YIELD UNDER LONG-TERM TILLAGE SYSTEMS
Authors: LUO ZHUZHU , GAN YANTAI , NIU YINING , ZHANG RENZHI , LI LINGLING , CAI LIQUN , XIE JUNHONG 
Published: September 2016

SUMMARYSoil quality indicators (SQI) can be used as a synthetic tool for the assessment of the sustainability of agricultural systems. In this study, we developed SQI using minimum data set (MDS) and determined the response of SQI to long-term tillage systems. Field pea (Pisum sativumL.) and spring wheat (Triticum aestivumL.) were grown in alternate years at northwestern China, and soil attributes and crop productivity were measured 6 years after the initiation of the experiment. The MDS used to develop the SQI included soil physical (aggregate, bulk density, capillary porosity, field capacity), chemical (soil organic matter, total nitrogen, available phosphorus, available potassium) and biological (microbial count, microbial biomass, and the activities of catalase, urease, alkaline phosphatase, and invertase) properties. All the property variables were measured in each of the 0–5, 5–10 and 10–30 cm depths and those variables that contributed significantly to the SQI were selected to be included in the MDS. Amongst the measured variables, bulk density and microbial counts occurred in the MDS of all the three depths, suggesting that these two properties are highly affected by the tillage treatments. In the long-term field experiment, the no-till with stubble covering the soil surface treatment received the greatest SQI score and achieved the highest crop yield. Soil quality under tillage systems can be assessed adequately using MDS measured at the top soil (0–5 cm) layer in rainfed agro-ecosystems.
Nematodes that associate with terrestrial molluscs as definitive hosts, includingPhasmarhabditis hermaphrodita(Rhabditida: Rhabditidae) and its development as a biological molluscicide
Authors: Pieterse A. , Malan A.P. , Ross J.L. 
Published: September 2016

AbstractTerrestrial molluscs (Mollusca: Gastropoda) are important economic pests worldwide, causing extensive damage to a variety of crop types, and posing a health risk to both humans and wildlife. Current knowledge indicates that there are eight nematode families that associate with molluscs as definitive hosts, including Agfidae, Alaninematidae, Alloionematidae, Angiostomatidae, Cosmocercidae, Diplogastridae, Mermithidae and Rhabditidae. To date,Phasmarhabditis hermaphrodita(Schneider, 1859) Andrássy, 1983 (Rhabditida: Rhabditidae) is the only nematode that has been developed as a biological molluscicide. The nematode, which was commercially released in 1994 by MicroBio Ltd, Littlehampton, UK (formally Becker Underwood, now BASF) under the tradename Nemaslug®, is now sold in 15 different European countries. This paper reviews nematodes isolated from molluscs, with specially detailed information on the life cycle, host range, commercialization, natural distribution, mass production and field application ofP. hermaphrodita.
Authorising humanitarian intervention: a five-point defence of existing multilateral procedures
Authors: Recchia Stefano 
Published: September 2016

AbstractEven scholars who support multilateralism in principle frequently question the value of securing approval from existing multilateral bodies for humanitarian intervention. The United Nations (UN) and regional organisations such as NATO, the argument goes, are far from democratic; furthermore, multilateralism is often a recipe for doing nothing; therefore, unauthorised intervention should be permissible in circumstances of ‘humanitarian necessity’. This article maintains that although today’s multilateral organisations and related procedures for authorising armed intervention may be suboptimal, they have significant output legitimacy. First, existing authorisation procedures reduce the risk of destabilising conflict spirals among powerful states. Second, they diminish the likelihood that humanitarianism will be used as a pretext. Third, they reduce epistemic problems concerning the identification of a just cause for intervention and thus the risk of accidental abuse. Fourth, they minimise the ‘moral hazard’ of humanitarian intervention. Finally, compliance with multilateral procedures is increasingly required for successful peacebuilding. This leads me to conclude that humanitarian warfare should always be authorised by the UN or regional multilateral organisations.
Onlinekommunikation und soziale Angst
Authors: Schulz Anja , Hoyer Jürgen 
Published: September 2016

Zusammenfassung. Hintergrund: Es wird die Literatur zu folgenden Fragen gesichtet: 1) Nutzen Menschen mit sozialer Angst das Internet und Onlinekommunikation stärker als andere? 2) Ist der Gebrauch des Internets bei sozial Ängstlichen hilfreich, weil er soziale Kontakte fördert oder stellt er eine aufrechterhalten Bedingung dar, weil Realkontakte subjektiv weniger wichtig werden? 3) Erleichtert oder erschwert die Option Onlinekommunikation die Psychotherapie der sozialen Angststörung? Methoden: Die bis Juli 2015 in Web of Science, PubMed oder PsycINFO gelisteten Arbeiten zur Thematik wurden gesichtet. Ergebnisse: Die 43 identifizierten Studien belegen, dass Menschen mit sozialer Angst das Internet nicht stärker nutzen, auch nicht zur Anbahnung zwischenmenschlicher Beziehungen. Sie haben eher weniger Online-Beziehungen, nutzen aber gleichzeitig überproportional Online- gegenüber Face-to-face-Kommunikation, insbesondere zur Selbstregulation. Schlussfolgerungen: Vor- und Nachteile der Onlinekommunikation für den Verlauf der sozialen Angst lassen sich empirisch belegen, wobei klinische Studien noch völlig fehlen. Onlinekommunikation gehört zur Alltagsrealität von Patienten mit sozialer Angst und ist in der Psychoedukation zur Störung sowie in der Fallkonzeption zu berücksichtigen.
The Effect of Enclothed Cognition on Empathic Responses and Helping	Behavior
Authors: López-Pérez Belén , Ambrona Tamara , Wilson Ellie L. , Khalil Marina 
Published: September 2016

Abstract. Based on the enclothed cognition framework, we tested whether the physical experience of wearing a tunic and identifying it with a nursing scrub may enhance empathic and helping responding, compared to the solely physical experience of wearing the scrub or associating with its symbolic meaning. Results of Study 1 (United Kingdom; n = 150) showed that participants who wore a tunic and identified it with a nursing scrub reported higher empathic concern and helped more in a punctual scenario, compared to the other two conditions. Results of Study 2 (Spain; n = 100) supported findings from Study 1 and showed that participants who wore a tunic and identified it with a nursing scrub volunteered more hours and showed higher response latency for altruistic motivation relevant words. Thus, the current research supports the enclothed cognition framework and shows that it also affects vicarious emotions and prosocial behavior.
The genome sequence of allopolyploid Brassica juncea and analysis of differential homoeolog gene expression influencing selection
Authors: Yang Jinghua , Liu Dongyuan , Wang Xiaowu , Ji Changmian , Cheng Feng , Liu Baoning , Hu Zhongyuan , Chen Sheng , Pental Deepak , Ju Youhui , Yao Pu , Li Xuming , Xie Kun , Zhang Jianhui , Wang Jianlin , Liu Fan , Ma Weiwei , Shopan Jannat , Zheng Hongkun , Mackenzie Sally A , Zhang Mingfang 
Published: September 2016

Abstract
The Brassica genus encompasses three diploid and three allopolyploid genomes, but a clear understanding of the evolution of agriculturally important traits via polyploidy is lacking. We assembled an allopolyploid Brassica juncea genome by shotgun and single-molecule reads integrated to genomic and genetic maps. We discovered that the A subgenomes of B. juncea and Brassica napus each had independent origins. Results suggested that A subgenomes of B. juncea were of monophyletic origin and evolved into vegetable-use and oil-use subvarieties. Homoeolog expression dominance occurs between subgenomes of allopolyploid B. juncea, in which differentially expressed genes display more selection potential than neutral genes. Homoeolog expression dominance in B. juncea has facilitated selection of glucosinolate and lipid metabolism genes in subvarieties used as vegetables and for oil production. These homoeolog expression dominance relationships among Brassicaceae genomes have contributed to selection response, predicting the directional effects of selection in a polyploid crop genome.
Brain Death and True Patient Care
Authors: Nguyen Doyen 
Published: September 2016

The “brain death” standard as a criterion of death is closely associated with the need for transplantable organs from heart-beating donors. Are all of these potential donors really dead, or does the documented evidence of patients destined for organ harvesting who improve, or even recover to live normal lives, call into question the premise underlying “brain death”? The aim of this paper is to re-examine the notion of “brain death,” especially its clinical test-criteria, in light of a broad framework, including medical knowledge in the field of neuro-intensive care and the traditional ethics of the medical profession. I will argue that both the empirical medical evidence and the ethics of the doctor–patient relationship point to an alternative approach toward the severely comatose patient (potential brain-dead donor). Lay Summary: Though legally accepted and widely practiced, the “brain death” standard for the determination of death has remained a controversial issue, especially in view of the occurrence of “chronic brain death” survivors. This paper critically re-evaluates the clinical test-criteria for “brain death,” taking into account what is known about the neuro-critical care of severe brain injury. The medical evidence, together with the understanding of the moral role of the physician toward the patient present before him or her, indicate that an alternative approach should be offered to the deeply comatose patient.
“Validity” and “Liceity” in Conjugal Acts: A Reply to Stephen Napier on the HIV-Condom Debate
Authors: Arias Joseph 
Published: September 2016

Stephen Napier has argued against the soundness of what he calls the “Canon-Law argument” against the moral permissibility of a couple employing a condom for the sake of one spouse avoiding the contraction of HIV from the other spouse. Without an attempt to provide a full defense of the Canon-Law argument per se, this paper argues that Napier has not shown that argument to be inadequate. Napier's critique of that argument suffers from unsubstantiated counterexamples and from a failure to take into account analogous senses of “procreative end” in reference to the conjugal act. Using magisterial documents and canonical sources, this paper suggests that the distinction between validity and liceity can be usefully applied to conjugal acts. Lay Summary: Stephen Napier has argued in favor of the claim that there is no plausible argument for thinking that married couples who use a condom in order to prevent HIV transmission are necessarily doing something morally wrong. In responding to Napier by showing that his arguments in favor of his claim are inconclusive, this article introduces a distinction, frequently used in sacramental theology, between validity and liceity (lawfulness) and applies this distinction to marital actions. I argue that some modifications to martial actions make them merely unlawful, whereas other modifications—such as using an intact condom—make them both unlawful and “invalid.”
Is Tube Feeding Futile in Advanced Dementia?
Authors: Lynch Matthew C. 
Published: September 2016

It is controversial whether tube feeding in people with dementia improves nutritional status or prolongs survival. Guidelines published by several professional societies cite observational studies that have shown no benefit and conclude that tube feeding in patients with advanced dementia should be avoided. However, all studies on tube feeding in dementia have major methodological flaws that invalidate their findings. The present evidence is not sufficient to justify general guidelines. Patients with advanced dementia represent a very heterogeneous group, and evidence demonstrates that some patients with dementia benefit from tube feeding. However, presently available guidelines make a single recommendation against tube feeding for all patients. Clinicians, patients, and surrogates should be aware that the guidelines and prior commentary on this topic tend both to overestimate the strength of evidence for futility and to exaggerate the burdens of tube feeding. Shared decision making requires accurate information tailored to the individual patient's particular situation, not blanket guidelines based on flawed data. Lay Summary: Many doctors believe that tube feeding does not help people with advanced dementia. Scientific studies suggest that people with dementia who have feeding tubes do not live longer or gain weight compared with those who are carefully hand fed. However, these studies are not very helpful because of flaws in design, which are discussed in this article. Guidelines from professional societies make a blanket recommendation against feeding tubes for anyone with dementia, but an individual approach that takes each person's situation into account seems more appropriate. Patients and surrogates should be aware that the guidelines on this topic tend both to underestimate the benefit and exaggerate the burdens of tube feeding.
Pitfalls in Inferring Human Microbial Dynamics from Temporal Metagenomics Data
Authors: Cao Hong-Tai , Gibson Travis E. , Bashan Amir , Liu Yang-Yu 
Published: September 2016

AbstractHuman gut microbiota is a very complex and dynamic ecosystem that plays a crucial role in our health and well-being. Inferring microbial community structure and dynamics directly from time-resolved metagenomics data is key to understanding the community ecology and predicting its temporal behavior. Many methods have been proposed to perform the inference. Yet, we point out that there are several pitfalls along the way, from uninformative temporal measurements to the compositional nature of the relative abundance data, focusing on highly abundant species by ignoring or grouping low-abundance species, and implicit assumptions in various regularization methods. These issues have to be seriously considered in ecological modeling of human gut microbiota.