bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parastomal hernia after ileal conduit: Incidence, natural history and risk factors
Authors: Blanc Pierre‐Yves , Fournel Isabelle , Bel Nicolas , Delchet Ophélie , Belloni Elena , Renard Yohann , Moszkowicz David , Romain Benoît , Passot Guillaume , Ortega‐Deballon Pablo ,   SFCP‐CH research network
Published: September 2024

AbstractIntroductionParastomal hernias are a challenging complication of digestive ostomies. Ileal‐conduit parastomal hernias after cystectomy have specific aspects. The aim of this study was to describe the incidence and natural history of ileal‐conduit parastomal hernias in order to guide their management, as well as to identify risk factors to prevent them.Patients and methodsAll consecutive patients undergoing cystectomy with a Bricker's ileal conduit in 3 academic centers were retrospectively identified. Data were collected regarding their medical history prior to cystectomy, the operation, the postoperative period, imaging results within 5 years of follow‐up, and the onset and timing of clinically or radiologically diagnosed ICPH.ResultsAmong 577 patients included in the study, 115 (20.6%) developed an ICPH during the study period. Most patients did not present any symptom and the diagnosis was made at imaging in 74.8% of them. Most hernias were detected between 1 and 2 years after the cystectomy, with a mean time to diagnosis of 12.4 months. At multivariate analysis, overweight and obesity were independent risk factors for developing an ICPH (adjusted hazard ratio [aHR] 1.96; p = 0.046), while a trans‐rectus position of the ostomy was a significant protective factor (aHR 0.45; p = 0.011).ConclusionsA PH develops in almost 20% of patients after ileal conduit urinary diversion, with a mean time of onset of 12.4 months. It is often a subclinical condition detected at medical imaging. Obesity increases the risk, while passing the ileal‐conduit through the rectus muscle can help to prevent it.
Heat transfer analysis of a peristaltically induced creeping magnetohydrodynamic flow through an inclined annulus using homotopy perturbation method
Authors: Yadav Pramod Kumar , Roshan Muhammad 
Published: September 2024

AbstractThe present work aims to focus on the heat transfer analysis of the peristaltic flow of biviscosity fluid in an annular region between two coaxial flexible tubes with different amplitudes and phases under the influence of a radially varying magnetic field and constant rotation. In this model, the non‐Newtonian biviscosity fluid is flowing through the annulus region between the two concentric inclined tubes. The outer flexible tube is permeable and supposed to satisfy the Saffman slip condition. The governing equations for the considered problem are simplified under the assumptions of a creeping flow and long‐wavelength approximations. Semi‐analytical expressions for the axial velocity and temperature profile are obtained using the homotopy perturbation method. Here, the expressions for shear stress and stream function are also obtained. In this work, the authors discussed the impact of various flow parameters like the Hartmann number, rotation of the frame, permeability parameter, phase difference, amplitude ratios of inner and outer tubes, radius ratio, and inclination angle on the above flow variables. The streamline contour plots are also drawn for the realization of the fluid flow inside the annular endoscopic region. A noticeable result which is drawn from the present study is that phase difference and amplitude ratio are responsible for reduction and enhancement in temperature and axial velocity of the moving fluid, respectively. It is also found from the present examination that the rise in the strength of the applied magnetic field enhances the transverse fluctuations of peristaltically propagating waves. The comparison of the sinusoidal waveform with the various types of waveforms, such as triangular, trapezoidal, and square waveforms, in the case of a peristaltic endoscope is also discussed. The proposed model may give insights into designing a novel endoscope and decide whether such types of peristaltic endoscopes have exemplary implementations for surgical and mechanical purposes.
Interpolating Between Rényi Entanglement Entropies for Arbitrary Bipartitions via Operator Geometric Means
Authors: Bugár Dávid , Vrana Péter 
Published: September 2024

AbstractThe asymptotic restriction problem for tensors can be reduced to finding all parameters that are normalized, monotone under restrictions, additive under direct sums and multiplicative under tensor products, the simplest of which are the flattening ranks. Over the complex numbers, a refinement of this problem, originating in the theory of quantum entanglement, is to find the optimal rate of entanglement transformations as a function of the error exponent. This trade-off can also be characterized in terms of the set of normalized, additive, multiplicative functionals that are monotone in a suitable sense, which includes the restriction-monotones as well. For example, the flattening ranks generalize to the (exponentiated) Rényi entanglement entropies of order $$\alpha \in [0,1]$$

α
∈
[
0
,
1
]

. More complicated parameters of this type are known, which interpolate between the flattening ranks or Rényi entropies for special bipartitions, with one of the parts being a single tensor factor. We introduce a new construction of subadditive and submultiplicative monotones in terms of a regularized Rényi divergence between many copies of the pure state represented by the tensor and a suitable sequence of positive operators. We give explicit families of operators that correspond to the flattening-based functionals, and show that they can be combined in a nontrivial way using weighted operator geometric means. This leads to a new characterization of the previously known additive and multiplicative monotones, and gives new submultiplicative and subadditive monotones that interpolate between the Rényi entropies for all bipartitions. We show that for each such monotone there exist pointwise smaller multiplicative and additive ones as well. In addition, we find lower bounds on the new functionals that are superadditive and supermultiplicative.
The DPP-4 inhibitor sitagliptin improves glycaemic control and early-stage diabetic nephropathy in adolescents with type 1 diabetes using the MiniMed 780G advanced hybrid closed-loop system: a randomised controlled trial
Authors: Elbarbary Nancy S. , Ismail Eman A. , El-Hamamsy Manal H. , Ibrahim Marwa Z. , Elkholy Amal A. 
Published: September 2024

Abstract
Aims/hypothesis
Dipeptidyl peptidase-4 (DPP-4) inhibition has beneficial effects on various metabolic indicators in diabetes. Stromal cell-derived factor-1 (SDF-1) is expressed in diverse organs including the kidneys and is cleaved and inactivated by DPP-4 enzyme. The aim of this study was to conduct a randomised controlled trial to assess the effect of sitagliptin on diabetic nephropathy when used as an add-on therapy to the advanced hybrid closed-loop (AHCL) system in adolescents with type 1 diabetes and nephropathy.

Methods
This open-label, parallel-group, randomised controlled trial took place at the Pediatric Diabetes Clinic, Ain Shams University, Egypt. Forty-six adolescents aged 14.13 ± 2.43 years on the MiniMed 780G system for at least 6 months before study, with HbA1c ≤69 mmol/mol (8.5%) and diabetic nephropathy in the form of microalbuminuria, were randomly assigned to two groups (n=23 for each) based on a computer-generated randomisation sequence. The intervention group received oral sitagliptin 50 mg for 3 months. The other group used AHCL only and served as a control group. The primary outcome measure was the change in urinary albumin/creatinine ratio (UACR) after 3 months of administration of sitagliptin. The key secondary outcome measure was the change from baseline in SDF-1 levels after treatment.

Results
Data for all participants were analysed. No significant difference was found between the groups as regards baseline clinical and laboratory characteristics as well as AHCL system settings (p>0.05). Serum SDF-1 levels were higher in all individuals with type 1 diabetes vs healthy control individuals (p<0.001). After 3 months, sitagliptin resulted in a significant decrease of SDF-1 levels from 3.58 ± 0.73 to 1.99 ± 0.76 ng/ml (p<0.001), together with improvement of UACR from 7.27 ± 2.41 to 1.32 ± 0.31 mg/mmol (p<0.001). In addition, sitagliptin reduced postprandial glucose, sensor glucose, coefficient of variation and total daily dose of insulin, while time in range 3.9–10.0 mmol/l (70–180 mg/dl) and insulin-to-carbohydrate ratio were significantly increased. Sitagliptin was safe and well-tolerated without severe hypoglycaemia or diabetic ketoacidosis.

Conclusions/interpretation
Sitagliptin as an add-on therapy to AHCL had a reno-protective effect for individuals with type 1 diabetes and diabetic nephropathy, in addition to the improvement of time in range while reducing glycaemic variability and without compromising safety.

Funding
This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.

Trial registration
ClinicalTrials.gov NCT06115460.

Graphical abstract
Development of a multi-fidelity optimisation strategy based on hybrid methods
Authors: Porta Ko Agustí , González Horcas Sergio , Pons-Prats Jordi , Bugeda Gabriel 
Published: September 2024

AbstractA multi-fidelity optimisation strategy has been developed in the present work, and its performance is illustrated through a series of test cases. The strategy is based on hybrid methods such that two genetic optimisation algorithms are employed, each coupled to a different fidelity level with transfer of information between them. The aim is that the low fidelity model, being less accurate but with a lower computational cost, performs a comprehensive search along the design space guiding the high fidelity model to the optimum region. This strategy has been shown to reduce the computational time of an optimisation through analytical test cases as well as numerical cases. The analytical cases have been used to tune the parameters that define the multi-fidelity strategy, while the numerical cases are employed to apply the method to engineering problems, focusing on the aerodynamic performance of an airfoil. The speed-up shows a certain dependency to the models relation, both regarding their similarity level as well as the relative computational cost. For cases exhibiting a significant dissimilarity between models, wherein the low fidelity model is notably inaccurate, the attained speed-up diminishes, and numerous instances demonstrate an absence of speed-up. However, for most cases, even with poor model similarity the optimisations are accelerated by an order of 2, while values up to 3–5 were found for higher similarity levels. Hence, the developed strategy shows a relevant decrease of computational cost of an optimisation procedure although its performance is affected by the models relative accuracy.
Resilient machine learning for steel surface defect detection based on lightweight convolution
Authors: Liu Li-Juan , Zhang Yu , Karimi Hamid Reza 
Published: September 2024

AbstractSteel, as a crucial material extensively used in various fields, has a critical impact on the determination of the stability and reliability of engineering structures. Nevertheless, because of inevitable factors in manufacturing, transportation, and other processes, steel may exhibit various surface defects during production and handling. To address these defects, the investigation puts forward a resilient machine-learning method for steel surface defect detection based on lightweight convolution. First, to reduce redundant features, complexity, and computational cost, the Spatial and Channel Reconstruction Convolution (ScConv) module is added before the Spatial Pyramid Pooling-Fast (SPPF) within the YOLOv8n’s backbone network. Second, in the Neck layer, lightweight convolution GSConv is used to replace the convolutional modules, and the efficient cross-stage partial network (CSP) module, VoV-GSCSP is substituted for the C2f module to alleviate the model burden while maintaining accuracy. Then, to focus on important information related to the current task, the Coordinate Attention module is added to the Neck layer. Finally, the activation function of YOLOv8n has been swapped for the Leaky Rectified Linear Unit (LeakyReLU) to effectively address issues such as gradient vanishing and overfitting. The method achieved a mean Average Precision (mAP) of 77.7% on the NEU-DET dataset, which is an improvement of 4.7% over the original YOLOv8n. Additionally, the frames per second (FPS) reached 17.36 f/s, representing a 5.79 f/s increase compared to the original YOLOv8n. On the GC10-DET dataset, mAP improves by 5.5%, with a FPS of 15.63 f/s. A plethora of experimentation on both datasets illustrates the method’s robustness, meeting the precision criteria for detecting metal defects.
Symplectic Geometry of Teichmüller Spaces for Surfaces with Ideal Boundary
Authors: Alekseev Anton , Meinrenken Eckhard 
Published: September 2024

AbstractA hyperbolic 0-metric on a surface with boundary is a hyperbolic metric on its interior, exhibiting the boundary behavior of the standard metric on the Poincaré disk. Consider the infinite-dimensional Teichmüller spaces of hyperbolic 0-metrics on oriented surfaces with boundary, up to diffeomorphisms fixing the boundary and homotopic to the identity. We show that these spaces have natural symplectic structures, depending only on the choice of an invariant metric on $$\mathfrak {sl}(2,\mathbb {R})$$

sl
(
2
,
R
)

. We prove that these Teichmüller spaces are Hamiltonian Virasoro spaces for the action of the universal cover of the group of diffeomorphisms of the boundary. We give an explicit formula for the Hill potential on the boundary defining the moment map. Furthermore, using Fenchel–Nielsen parameters we prove a Wolpert formula for the symplectic form, leading to global Darboux coordinates on the Teichmüller space.
A Resonant Lyapunov Centre Theorem with an Application to Doubly Periodic Travelling Hydroelastic Waves
Authors: Ahmad R. , Groves M. D. , Nilsson D. 
Published: September 2024

AbstractWe present a Lyapunov centre theorem for an antisymplectically reversible Hamiltonian system exhibiting a nondegenerate 1 : 1 or $$1:-1$$

1
:
-
1

semisimple resonance as a detuning parameter is varied. The system can be finite- or infinite-dimensional (and quasilinear) and have a non-constant symplectic structure. We allow the origin to be a ‘trivial’ eigenvalue arising from a translational symmetry or, in an infinite-dimensional setting, to lie in the continuous spectrum of the linearised Hamiltonian vector field provided a compatibility condition on its range is satisfied. As an application, we show how Kirchgässner’s spatial dynamics approach can be used to construct doubly periodic travelling waves on the surface of a three-dimensional body of water (of finite or infinite depth) beneath a thin ice sheet (‘hydroelastic waves’). The hydrodynamic problem is formulated as a reversible Hamiltonian system in which an arbitrary horizontal spatial direction is the time-like variable, and the infinite-dimensional phase space consists of wave profiles which are periodic (with fixed period) in a second, different horizontal direction. Applying our Lyapunov centre theorem at a point in parameter space associated with a 1 : 1 or $$1:-1$$

1
:
-
1

semisimple resonance yields a periodic solution of the spatial Hamiltonian system corresponding to a doubly periodic hydroelastic wave.
Early experience with targeted and combination biopsies in prostate cancer work-up in Denmark from 2012 to 2016
Authors: Blak Anna Arendt , Stroomberg Hein V. , Brasso Klaus , Larsen Signe Benzon , Røder Andreas 
Published: September 2024

Abstract
Purpose
To investigate the early implementation of combined systematic and targeted (cBx) primary biopsy in prostate cancer diagnosis and define the concordance in Gleason grading (GG) of different biopsy techniques with radical prostatectomy (RP) pathology.

Methods
This population-based analysis includes data on all men in Denmark who underwent primary cBx or standalone systematic (sBx) prostate biopsy between 2012 and 2016. Biopsy results were compared to RP pathology if performed within a year. Concordance measurement was estimated using Cohen’s Kappa, and the cumulative incidence of cancer-specific death was estimated at 6 years with the Aalen-Johansen estimator.

Results
Concordance between biopsy and RP pathology was 0.53 (95CI: 0.43–0.63), 0.38 (95CI: 0.29–0.48), and 0.16 (95CI: 0.11–0.21) for cBx, targeted biopsy (tBx), and sBx, respectively. For standalone sBx and RP, concordance was 0.29 (95CI: 0.27–0.32). Interrelated GG concordance between tBx and sBx was 0.67 (95CI: 0.62–0.71) in cBx. The proportion of correctly assessed GG based on RP pathology was 54% in both cBx and standalone sBx. Incidence of prostate cancer-specific death was 0% regardless of biopsy technique in GG 1, and 22% (95CI: 11–32), 30% (95CI: 15–44), and 19% (95CI: 7.0–30) in GG 5 for cBx, tBx, or sBx, respectively.

Conclusion
Overall, the cBx strategy demonstrates higher concordance to RP pathology than the standalone sBx. However, cBx exhibits more overgrading of the GG of RP pathology compared to sBx. Ultimately, the classic grading system does not take change in the diagnostic pathway into account, and grading should be altered accordingly to ensure appropriate treatment.
Increased rate of injuries to the anterior cruciate ligament in amateur soccer players after the COVID-19 pandemic lockdown
Authors: Memmel Clemens , Krutsch Werner , Weber Johannes , Huber Lorenz , Kerschbaum Maximilian , Rupp Markus , Alt Volker , Szymski Dominik 
Published: September 2024

AbstractThe COVID-19 pandemic led to the discontinuation of soccer activities at all levels of play. Injuries to the anterior cruciate ligament (ACL) are still one of the most severe injuries in soccer. The aim of this investigation was to analyze the changes in the incidence and mechanism of ACL injuries in professional and amateur soccer before and after the lockdown period. Injury data were prospectively collected using the database ‘ACL registry in German soccer’. Between 2019 and 2021, 10 matches in professional, semi-professional, and amateur leagues before and after the lockdown were analyzed for the incidence and mechanism of ACL injuries. Data were collected using standardized and recently published study methods. Mean incidence of the 84 ACL injuries recorded during the study period was 0.083 injuries per 1000 h of exposure before and 0.079 injuries per 1000 h of exposure after the lockdown period (p = 0.699). In amateur soccer, the incidence of ACL injuries increased significantly from 0.058 injuries per 1000 h of exposure before to 0.128 injuries per 1000 h of exposure after the lockdown period (p = 0.026), in contrast to professional (p = 0.436) and semi-professional (p = 0.802) soccer. The predominant mechanisms of ACL injuries were non-contact injuries (pre-COVID: 59.1%; post-COVID: 57.7%) and indirect contact injuries (pre-COVID: 31.8%; post-COVID: 30.8%). The absence from training and match practice in German soccer during the COVID-19 lockdown led to a significantly increased ACL injury rate in amateur leagues, while in professional and semi-professional soccer no differences were reported. The mechanism of ACL injuries did not change after the lockdown period.Level of evidence: II.
Helicobacter pylori and acne vulgaris: is there a relationship?
Authors: Afify Ahmed Abdelfattah , Saleh Hanan Mohamed Ahmed , Hussein Abeer Farrag 
Published: September 2024

AbstractBackground: Helicobacter pylori (H. pylori) is a gastric Gram-negative, spiral-shaped microaerophilic pathogen. H. pylori may play a potential pathogenic role in extra-intestinal diseases such as hepatobiliary, respiratory, and dermatological disorders. The latter included chronic urticaria, psoriasis and rosacea. The first report in literature on the relationship between H. pylori and acne vulgaris (AV), found association between severe AV and H. pylori infection. There are very limited data in AV patients addressing the impact of H. pylori infection on various severities. In this context, the aim of the present work was to determine the association of H. Pylori infection among AV patients and correlate it with the disease severity. Methods: This case-control study included 45 Patients with AV and 45 age and sex matched healthy volunteers as a control group. H. pylori antigen in stool and serum H. pylori antibody IgG using commercially available ELISA kits was tested in all included subjects. Results: The percentage of participants with a positive H. pylori antigen in stool and positive H. pylori antibody in serum in the whole study population was 35/90 (38. 9%) and 41/90 (45. 6%). On comparing between the percentages of positive H. pylori antigen in stool and positive H. pylori antibody in serum between the patients with AV and healthy controls, a highly statistically significant difference was found between the two groups (P < 0.001, P = 0.006). On comparing between the percentages of positive H. pylori antigen in stool and positive H. pylori antibody in serum in the patients with different grades of acne severity and healthy controls, the rate of positive H. pylori antigen in stool and positive H. pylori Ab in serum was significantly associated with severity of acne comparing with healthy controls (p < 0. 001). Conclusion: The rate of H. pylori infection in patients with AV is high so it may influence the pathogenesis of this skin disease. Patients with severe AV had higher rates of H. pylori antigen in stool and H. pylori antibody in serum as compared to the patients with mild AV and healthy controls.
On questions of uniqueness for the vacant set of Wiener sausages and Brownian interlacements
Authors: Mu Yingxin , Sapozhnikov Artem 
Published: September 2024

AbstractWe consider connectivity properties of the vacant set of (random) ensembles of Wiener sausages in $${\mathbb {R}}^d$$

R

d

in the transient dimensions $$d \ge 3$$

d
≥
3

. We prove that the vacant set of Brownian interlacements contains at most one infinite connected component almost surely. For finite ensembles of Wiener sausages, we provide sharp polynomial bounds on the probability that their vacant set contains at least 2 connected components in microscopic balls. The main proof ingredient is a sharp polynomial bound on the probability that several Brownian motions visit jointly all hemiballs of the unit ball while avoiding a slightly smaller ball.
A consistent discretization via the finite radon transform for FFT-based computational micromechanics
Authors: Jabs Lukas , Schneider Matti 
Published: September 2024

AbstractThis work explores connections between FFT-based computational micromechanics and a homogenization approach based on the finite Radon transform introduced by Derraz and co-workers. We revisit periodic homogenization from a Radon point of view and derive the multidimensional Radon series representation of a periodic function from scratch. We introduce a general discretization framework based on trigonometric polynomials which permits to represent both the classical Moulinec-Suquet discretization and the finite Radon approach by Derraz et al. We use this framework to introduce a novel Radon framework which combines the advantages of both the Moulinec-Suquet discretization and the Radon approach, i.e., we construct a discretization which is both convergent under grid refinement and is able to represent certain non-axis aligned laminates exactly. We present our findings in the context of small-strain mechanics, extending the work of Derraz et al. that was restricted to conductivity and report on a number of interesting numerical examples.