bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chinese Version of the Nonverbal Pain Assessment Tool: Critical Patient Reliability and Validity
Authors: Jia Donghui , Wang Shengjun , Wang Qian , Wang Hengyang , Xie Haohao , Jiang Youfei , Zhang Zhigang , Lyu Xinghua 
Published: October 2024

ABSTRACTAims and ObjectivesTo translate and validate the Nonverbal Pain Assessment Tool.BackgroundTimely assessment of the pain degree of nonverbal intensive care unit (ICU) patients can provide humanistic care. However, there is a lack of pain assessment tools that can meet the needs of patients who cannot use language in ICUs in China.DesignA cross‐sectional survey.MethodsWe conducted forward–backward translation of the Nonverbal Pain Assessment Tool. A total of 300 critically ill patients in the intensive care unit who could not communicate verbally completed the Chinese version of the Nonverbal Pain Assessment Tool and the Critical Care Pain Observation Tool. Exploratory and confirmatory factor analyses were performed to verify structural validity, and content validity and reliability analyses were also conducted.ResultsThe Nonverbal Pain Assessment Tool demonstrated high internal consistency (α = 0.901) and interrater reliability (intraclass correlation coefficient = 0.981), with good split‐half reliability. Content validity was established through acceptable item‐level content validity index and scale‐level content validity index scores. Exploratory factor analysis showed a single factor explaining 71.79% of total variance, and confirmatory factor analysis confirmed good model fit. The Spearman rank correlation coefficient was 0.917 between the Nonverbal Pain Assessment Tool and the Critical Care Pain Observation Tool. The Chinese Nonverbal Pain Assessment Tool demonstrated significant differences in scores between different states of consciousness and illness severity, supporting its known‐groups validity.ConclusionThe Chinese version of the Nonverbal Pain Assessment Tool is a reliable and valid tool for nonverbal pain assessment in ICU patients in China.Relevance to Clinical PracticeThe Chinese version of the Nonverbal Pain Assessment Tool can assess the pain of patients who cannot use language in ICU, which provides a new valuable assessment tool for Chinese clinicians and nurses in pain assessment and management.Reporting MethodOur study followed the STROBE Checklists.Patient or Public ContributionPatients actively cooperated and participated in data collection during the implementation of the study.
An Inconvenient Truth: A Comprehensive Examination of the Added Value (or Lack Thereof) of Leadership Measures
Authors: Eva Nathan , Howard Joshua L. , Liden Robert C. , Morin Alexandre J.S. , Schwarz Gary 
Published: October 2024

AbstractThe leadership literature encompasses a bewildering array of leadership styles, with most studies focussing on the nature and consequences of a single leadership style in isolation. This isolationist approach has led researchers to mostly ignore the similarities between supposedly different leadership styles, and few studies have examined these overlaps empirically. To understand the extent of this problem, we use bifactor exploratory structural equation modelling to examine whether 12 dominant leadership measures capture shared variance and whether any variance unique to a particular style is related to theoretically and empirically established covariates. Moreover, we explore what the shared variance of these leadership measures may represent. Across seven samples, five countries, multiple organizational contexts, and 4000 respondents, the 12 leadership measures shared significant amounts of variance and did not systematically capture unique leadership‐related variance. Further analyses indicated this shared variance mainly represented the affective quality of the leader–follower relationship. The results reveal an inconvenient truth for leadership researchers who wish to differentiate styles, as the styles have much more in common than differences. Contrasting with previous recommendations to refine styles, we argue that a taxonomic leadership behaviour categories approach to leadership research is the most parsimonious way forward.
The association of early passive mobilization with intracranial pressure in the adult intensive care unit: A prospective, cohort study
Authors: Küçük Ahmet Oğuzhan , Hatınoğlu Neslihan , Apaydin Umut , Altunalan Turgay , Küçük Mehtap Pehlivanlar 
Published: October 2024

AbstractBackgroundEarly mobilization are key components of the ABCDEF Care Bundle and critical treatments to reduce acquired muscle weakness, delirium and prolonged intensive care unit (ICU) stay.AimThis study aimed to determine whether routine early mobilization related to intracranial pressure in intensive care patients on mechanical ventilation, using optic nerve sheath diameter measurement (ONSD).Study designThis study was planned as a prospective, cohort study in the third‐step adult ICU of a faculty hospital. The study included only patients who were intubated and followed up on a mechanical ventilator and were clinically stable. Passive range of motion (PROM) exercises were performed daily by the physiotherapists as part of routine care from the day of hospitalization. ONSD was assessed before, during and 10 min after PROM exercises.ResultsThe study included 20 eligible patients out of the 142 who were evaluated upon admission to the ICU. The median age of the patients was 65 years, and nine (45%) of them were female. The analyses showed that there was no statistically significant change in ONSD during and at the end of the PROM (ONSD right eye p:.621, Partial η2: 0.025, ONSD left eye p:.935, Partial η2: 0.004). Similarly, there was no statistically significant change in haemodynamic parameters in during and at the end of the PROM (Heart beat p:.849, Partial η2: 0.009, Systolic Pressure p:.435, Partial η2: 0.043, Diastolic Pressure p:.128, Partial η2:0.103, Saturation p:.103, Partial η2: 0.113 and Respiratory rate p:.071, Partial η2:0.130).ConclusionThis study suggests that daily extremity physiotherapy exercises can be safely applied without causing increased intracranial pressure or haemodynamic instability in intensive care patients followed up on mechanical ventilation, including patients with vasopressor therapy.Relevance to Clinical PracticeEarly mobilization, including PROM, is considered safe in terms of intracranial pressure for intubated patients in the ICU.
Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2
Authors: Lin Yi‐Wen , Lin Feng‐Yen , Lai Ze‐Hao , Tsai Chien‐Sung , Tsai Yi‐Ting , Huang Yen‐Sung , Liu Chen‐Wei 
Published: October 2024

AbstractInfection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression. The periodontal pathogen Porphyromonas gingivalis is highly associated with the progression of periodontitis. GroEL protein of periodontal pathogens is an important virulence factor that can invade the body through either the bloodstream or digestive tract and is associated with numerous systemic diseases. Although P. gingivalis aggravates AAA by increasing the expression of MMP‐2 in animal studies, the molecular mechanism through which P. gingivalis regulates the expression of MMP‐2 is still unknown and requires further investigation.In this study, we first confirmed through animal experiments that P. gingivalis GroEL promotes MMP‐2 secretion from vascular SMCs, thereby aggravating Ang II‐induced aortic remodeling and AAA formation. In addition, rat vascular SMCs and A7r5 cells were used to investigate the underlying mechanisms in vitro. The results demonstrated that GroEL can promote the interaction between the K639 site of MMP‐2 and SUMO‐1, leading to MMP‐2 SUMOylation, which inhibits the reoccurrence of non–K639‐mediated monoubiquitylation. Hence, the monoubiquitylation‐mediated lysosomal degradation of MMP‐2 is inhibited, consequently promoting MMP‐2 stability and production. SUMOylation may facilitate intra‐endoplasmic reticulum (ER) and Golgi trafficking of MMP‐2, thereby enhancing its transport capacity. In conclusion, this is the first report demonstrating the presence of a novel posttranslational modification, SUMOylation, in the MMP family, suggesting that P. gingivalis GroEL may exacerbate AAA formation by increasing MMP‐2 production through SUMOylation in vascular SMCs. This study also provides a novel perspective on the role of SUMOylation in MMP‐2–induced systemic diseases.
The duty to listen
Authors: Joshi Hrishikesh , McKenna Robin 
Published: October 2024

AbstractIn philosophical work on the ethics of conversational exchange, much has been written regarding the speaker side—i.e., on the rights and duties we have as speakers. This paper explores the relatively neglected topic of the duties pertaining to the listeners’ side of the exchange. Following W.K. Clifford, we argue that it's fruitful to think of our epistemic resources as common property. Furthermore, listeners have a key role in maintaining and improving these resources, perhaps a more important role than speakers. We develop this idea by drawing from Hugo Mercier and Dan Sperber's “interactionist” picture of reason, which suggests that reasoning is essentially dialogical and relies on the epistemic vigilance of listeners. The paper defends an imperfect, prima facie duty to listen, one that is sufficiently strong to place substantial demands on individuals, but not so overly demanding as to be implausible.
Shepherd's social epistemology: A nonreductive theory of testimony and the question of epistemic autonomy
Authors: Bartha David 
Published: October 2024

AbstractIn this article, I extract Mary Shepherd's social epistemology primarily from her attack on Hume's dismissive account of miracle reports. On my reading, she adopts a nonreductionist position on testimony, arguing that the hearer is both caused and justified to regard testimonies as true by default, that is, in the absence of any undefeated defeater. In contrast to Humean reductionism, we do not need to provide positive evidence for the truth of the testified proposition, for instance, by appealing to the observed reliability of the speaker or speakers generally. In fleshing out her account, I clarify why her nonreductionism does not lead Shepherd to question our epistemic autonomy—the idea that we are supposed to draw our own conclusions. Indeed, I argue that it is precisely her commitment to epistemic autonomy that explains why, despite following Reid's similar account of testimony, she emphatically denies that we could justify metaphysical principles by appealing to common sense or universal agreement among people. Relatedly, I suggest that Shepherd thinks that while we have an a priori right to trust testimonies about events (whether ordinary or extraordinary) that we have not witnessed ourselves, we should never base our philosophical judgments simply on others' authority.
Local credit and international trade
Authors: Vavrus Joseph , Xu Nan 
Published: October 2024

AbstractThis study investigates the relationship between local access to credit and exports. A model of finance‐constrained exporters and bank entry decisions generates trade equations that we estimate with a panel of Brazilian municipal‐level trade and banking data. Literature in the financial development field has struggled to deal with the endogenous relationship between finance and economic outcomes. To untangle this reverse causality, we instrument bank presence by using geographic characteristics particular to the bank branching decision. The results show that local bank access matters: increases in bank branches per person increases bilateral exports and varieties at the city‐ and industry levels. The effect is even stronger for industries where the credit constraint binds, specifically those that use less internal funds and have more difficulty producing collateral.
Supplemental Material: Nitrogen (N) and its isotopes in serpentinized forearc wedges and implications for N cycling across subduction zones
Authors: Bustos Moreno Juan Felipe , al. et 
Published: October 2024

<p>Photomicrographs of sample 1H-5W (18-20) from South Chamorro Site 1200F (Fig. S1), analytical techniques (Fig. S2), mixing model (Fig. S3), calculation of global N reservoir in serpentinized forearc wedges (Fig. S4), and whole-rock N concentration and isotopic data (Table S1). </p>
From Screens to Minds: The Connection Between Cyberbullying, Psychological Well‐Being, and the Mediating Role of Perceived Social Support in High School Students
Authors: Kahi Malihe , Heidari Zahra , Esmaeili Maryam , Samouei Rahele , Amini-Rarani Mostafa 
Published: October 2024

Introduction: Bullying has become a growing concern among adolescents, particularly in the context of cyberbullying, where electronic devices are used to harass others. Understanding the distinct roles of cyberbullies and victims of cyberbullying in relation to various consequences on psychological well‐being is crucial. Therefore, this research aimed to investigate the mediating role of perceived social support in explaining the relationship between cyberbullying and the psychological well‐being of secondary high school students.Method: This study employed a cross‐sectional design, in high school students (aged 15–18 years) in Isfahan city, Iran, in 2021. A stratified sampling method was used to select 1051 students. Data were collected through a checklist and three cyberbullying psychological well‐being and perceived social support questionnaires. Considering that the purpose of the study was to examine a set of dependency relationships, the data were analyzed using Statistical Package for the Social Sciences (SPSS), Mplus, and Analysis of Moment Structures (AMOS) softwares and the structural equation method was applied.Results: The results revealed a significant negative relationship between cyberbullying, psychological well‐being, and all its dimensions, except for autonomy and positive relationship with others. Conversely, a positive and significant relationship was observed between cyberbullying victims and psychological well‐being, except for purpose in life dimension. Additionally, there was a negative and significant relationship between cyberbullying, cyber victimization, and perceived social support, including its dimensions. Furthermore, perceived social support was found to mediate the relationship between cyberbullying and psychological well‐being significantly.Conclusion: The study highlights that high school students involved in cyberbullying and cyber victimization are susceptible to a decline in their psychological well‐being. Therefore, it is imperative for parents, teachers, and education officials to understand the role of social support to mitigate the negative impacts of cyberbullying in adolescents.
A Meta-analysis of the Profit-Sharing Practices among Engineering, Construction, and Related Firms: Strategy to Increase Company Revenue
Authors: Siman Bennegreg P. 
Published: October 2024

This paper explores the impact of profit sharing on employee motivation, productivity, and company performance in the engineering and construction industry. Through a meta-analysis of recent studies, it identifies key factors that influence the effectiveness of profit-sharing programs. The findings reveal that profit sharing significantly boosts employee motivation and productivity, with increases of 15% and 12% respectively. Moreover, job satisfaction rates are 20% higher among employees participating in profit-sharing programs. However, there is a notable preference split, with 60% of employees favoring profit sharing for its potential higher earnings, while 40% prefer fixed salary increases for stability. The research further indicates that frequent and actively managed profit-sharing distributions, such as quarterly payouts, lead to better financial performance, with a 10% increase in overall performance and a 5% improvement in profitability. Project-based profit sharing in the construction sector is particularly effective, resulting in a 25% increase in project completion rates and a 15% reduction in project costs. Additionally, profit sharing is more effective in unionized organizations, with an 18% increase in effectiveness, and mandatory profit-sharing frameworks enhance worker satisfaction and productivity. Based on these findings, the paper recommends developing tailored profit-sharing strategies that cater to different employee preferences, implementing frequent and active management of profit-sharing distributions, adopting project-based profit sharing in project-centric industries, engaging with unions for fair terms, advocating for supportive regulatory frameworks, and continuously monitoring and evaluating the effectiveness of these programs. By adopting these strategies, engineering and construction firms can enhance employee motivation, improve productivity, and achieve better financial performance, driving organizational success.
Digitalized Learning Module in Cookery for Grade 11 Students
Authors: Palomeras Patrick A. 
Published: October 2024

This study focused on the development and evaluation of the Digitalized Learning Module in Cookery for Grade 11 Students of a public national high school in Antipolo City for the third quarter of the school year 2022-2023. In this study, weighted mean was utilized to ascertain how well the created digitalized learning module in cookery for Grade 11 students was received by instructors and expert responses. Independent-samples z Test was utilized to determine whether there was a statistically significant difference between the two sets of respondents' assessments of the created digitalized learning module in cookery for Grade 11 students. The study involved 30 respondents to complete the research investigation. It was revealed that both the TLE/TVL experts and TLE/TVL teachers agreed that the use of Digitalized Learning Module in Cookery among Grade 11 Students and its evaluation received very satisfactory ratings across multiple quality dimensions. Further, adopting a Digitalized Learning Module in Cookery for Grade 11 students can help improve their academic performance even when learning online. The Digitalized Learning Module may be a very useful tool to facilitate teaching Cookery for Grade 11 TVL class that could prepare students to develop critical thinking which may lead to higher academic performance in the subject. The use of the strategy is recommended for further research and may be applied to other subjects.
Stent Underexpansion Is an Underestimated Cause of Intrastent Restenosis: Insights From RESTO Registry
Authors: Souteyrand Géraud , Mouyen Thomas , Honton Benjamin , Mulliez Aurélien , Lattuca Benoit , Dilinger Jean‐Guillaume , Levesque Sébastien , Range Grégoire , Combaret Nicolas , Marliere Stéphanie , Lamallem Ouarda , Quillot Marine , Gerbaud Edouard , Motreff Pascal , Amabile Nicolas 
Published: October 2024

Background
Despite improvement in devices, in‐stent restenosis remains a frequent and challenging complication of percutaneous coronary interventions.

Methods and Results

The RESTO (Morphological Parameters of In‐Stent Restenosis Assessed and Identified by OCT [Optical Coherence Tomography]; study NCT04268875) was a prospective multicenter registry including patients presenting with coronary syndromes related to in‐stent restenosis. All patients underwent preintervention OCT analysis, which led to analysis of in‐stent restenosis phenotype, number of strut layers, and presence of stent underexpansion. The primary end point was the in‐stent restenosis type according to the OCT morphological classification. The 1‐year incidence of target vessel failure (a composite of death from cardiac causes, target‐vessel myocardial infarction, or ischemia‐driven target‐vessel revascularization) was assessed. The study included 297 patients. The culprit stent was a drug‐eluting stent in 74.2% of cases. OCT analysis revealed the presence of neoatherosclerosis in 57% (52% calcified), neointimal hyperplasia in 43% (58% homogeneous), stent underexpansion (minimal stent area <4.5 mm
2
) in 43%, and multiple stent layers in 30%. The prepercutaneous coronary intervention OCT analysis modified the operator's strategy for management in 30% of cases. Treatment involved drug‐eluting stent implantation in 61.6% and drug‐eluting balloon angioplasty in 36.1% of cases with only 63.2% optimal results. The 1‐year target vessel failure incidence was 11% (95% CI, 9%–13%). Residual postpercutaneous coronary intervention stent underexpansion was associated with significantly higher target vessel failure incidence (19% [95% CI, 14%–24%] versus 7% [95% CI, 5–9],
P
=0.01).

Conclusions
OCT identified neoatherosclerosis and neointimal hyperplasia in comparable proportions. Stent underexpansion was frequent and favored subsequent adverse clinical outcomes.
Dexmedetomidine ameliorates acute kidney injury by regulating mitochondrial dynamics via the α2-AR/SIRT1/PGC-1α pathway activation in rats
Authors: Zhang Shuai , Feng Xiujing , Yang Guiyan , Tan Haoyang , Cheng Xin , Tang Qichao , Yang Haotian , Zhao Yuan , Ding Xuanpan , Li Siyao , Dou Xinyi , Li Junfeng , Kang Huijie , Li Xingxing , Ji Yaxin , Hou Qingdian , An Qiuyue , Fang Hao , Fan Honggang 
Published: October 2024

Abstract
Background
Sepsis-associated acute kidney injury (AKI) is a serious complication of systemic infection with high morbidity and mortality in patients. However, no effective drugs are available for AKI treatment. Dexmedetomidine (DEX) is an alpha 2 adrenal receptor agonist with antioxidant and anti-apoptotic effects. This study aimed to investigate the therapeutic effects of DEX on sepsis-associated AKI and to elucidate the role of mitochondrial dynamics during this process.

Methods
A lipopolysaccharide (LPS)-induced AKI rat model and an NRK-52E cell model were used in the study. This study investigated the effects of DEX on sepsis-associated AKI and the molecular mechanisms using histologic assessment, biochemical analyses, ultrastructural observation, western blotting, immunofluorescence, immunohistochemistry, qRT-PCR, flow cytometry, and si-mRNA transfection.

Results
In rats, the results showed that administration of DEX protected kidney structure and function from LPS-induced septic AKI. In addition, we found that DEX upregulated the α2-AR/SIRT1/PGC-1α pathway, protected mitochondrial structure and function, and decreased oxidative stress and apoptosis compared to the LPS group. In NRK-52E cells, DEX regulated the mitochondrial dynamic balance by preventing intracellular Ca2+ overloading and activating CaMKII.

Conclusions
DEX ameliorated septic AKI by reducing oxidative stress and apoptosis in addition to modulating mitochondrial dynamics via upregulation of the α2-AR/SIRT1/PGC-1α pathway. This is a confirmatory study about DEX pre-treatment to ameliorate septic AKI. Our research reveals a novel mechanistic molecular pathway by which DEX provides nephroprotection.