bluuebunny/crossref_metadata_2025_split huggingface dataset:
High Ion‐Conductive Interphase Enabled by Nitrate‐Ionic Liquid Additive for Low‐Temperature Lithium Metal Batteries
Authors: He Zhigang , Tu Haifeng , Sun Guochao , Sun Ao , Wang Yuchen , Sun Jiapeng , Wu Guosong , Li Wanfei , Xu Jingjing , Liu Meinan 
Published: September 2024

AbstractThe development of high‐performance low‐temperature lithium metal batteries (LMBs) is hindered by severe lithium dendrite growth and sluggish charge transfer, both of which can be effectively addressed by constructing a robust solid electrolyte interphase (SEI) with improved Li+ transport kinetics. Compared to the soft organic SEI layers, LiF‐rich SEI shows sufficient mechanical strength to impede lithium dendrite growth, however, its extremely low ionic conductivity (≈10−13 S cm−1) hinders Li+ transport kinetics at low temperatures. Herein, a quasi‐ionic liquid (QIL, [Li(15‐crown‐5)]NO3) additive with rich NO3− is developed by introducing 15‐crown‐5 into LiNO3, which induces the in situ formation of SEI with abundant Li3N. Impressively, this Li3N SEI exhibits superior lithium affinity and lower ionic diffusion barriers as learned from empirical and computational studies, suggesting that it may be powerful to conquer the sluggish Li+ kinetics at low temperature. With the assistance of QIL additive, Li/LiCoO2 cells with a high mass loading of 11.5 mg cm−2 demonstrate stable cycling for 250 cycles without any capacity decay at ‐20 °C. This work opens an emerging avenue to construct high‐performance low‐temperature LMBs by manipulating SEI composition.
Roughened Graphite Collector Coupled with Hydrolysis‐Resistance Zinc Chloride Electrolyte Enables Large‐Size Rechargeable Ag–Zn Battery
Authors: Deng Yifan , Wu Jie , Zhang Minggang , Mei Hui , Chen Chao , Cheng Laifei , Zhang Litong 
Published: September 2024

AbstractAg–Zn batteries have the advantages of being a high‐safety and stable discharge platform but still face challenges such as high cost, electrolyte hydrolysis, and zinc dendrites. In this study, a low‐cost roughness graphite paper (GP) enables more uniform loaded Ag particles to construct Ag/rough graphite paper (Ag/RGP) cathode with high wettability of low‐concentration ZnCl2 electrolyte, achieving both capacity and reversibility enhancement. Both a few additions of citric acid (CA) to the low‐concentration ZnCl2 electrolyte can also inhibit the hydrolysis of Zn2+ and increase the nucleation overpotential due to suitable acidity and complexation ability, resulting in more even Zn deposited behavior on low‐cost Zn foil anode. Meanwhile, the ZnCl2‐CA electrolyte can also promote redox reaction and thus improve the capacity of the Ag/RGP cathode. As a result, the assembled large‐size Ag–Zn battery (50 cm2) with low‐cost Ag/RGP and low‐concentration ZnCl2‐CA obtains a capacity of 0.76 mAh cm−2 at a current density of 0.4 mA cm−2, with a cycle life of ≈100% capacity retention over 50 cycles, also easily powering a LED array and displaying high practicability. This work provides a feasible and practical route to fabricate large‐size and low‐cost Ag–Zn batteries.
Role of Inter‐Particle Connectivity in the Photo‐Carrier Cooling Dynamics in Perovskite Quantum Dot Solids
Authors: Tiede David O. , Koch Katherine A. , Romero‐Pérez Carlos , Ucer K. Burak , Calvo Mauricio E. , Galisteo‐López Juan F. , Míguez Hernán , Srimath Kandada Ajay Ram 
Published: September 2024

AbstractIntraband carrier relaxation in quantum dots (QDs) has been a subject of extensive spectroscopic investigation for several decades, and have been used to optimize the efficiency of opto‐electronic processes. In the past few years, metal halide perovskites‐based QDs have been shown to exhibit slow hot‐carrier cooling characteristics that are desirable for photo‐energy harvesting technologies. While several mechanisms are proposed to rationalize the retardation of the cooling dynamics, including hot‐phonon bottleneck and polaronic effects, the role of inter‐particle connectivity in these dynamics is largely ignored. Here, an in‐depth study of photo‐excitation dynamics and carrier cooling on perovskite QD solids with varying degrees of inter‐dot coupling is presented. It is observed that inter‐particle connectivity has deterministic effects on the many‐body interactions that are relevant for carrier cooling. These include carrier–carrier interactions that result in Auger‐reheating of the carriers, and lattice characteristics that subsequently affect the phonon‐assisted cooling dynamics. This spectroscopic study of ultrafast carrier dynamics in perovskite QD solids establishes inter‐dot separation as a critical material design parameter for the optimization of photo‐generated carrier temperature, which fundamentally determines the luminescence characteristics and thus the opto‐electronic quality of the material.
Upconversion‐Linked Branched DNA Hybridization Assay for the Detection of Bacteriophage M13
Authors: Brandmeier Julian C. , Kuusinen Saara , Farka Zdeněk , Soukka Tero , Gorris Hans H. 
Published: September 2024

AbstractThe demand for highly sensitive methods of pathogen detection drives the development of new diagnostic assays. While nucleic acid amplification methods such as PCR are very sensitive and remain widely used, they may be limited in complex sample matrices due to the presence of polymerase inhibitors. On the other hand, the direct detection of nucleic acids by DNA hybridization assays is simple but typically less sensitive. This work combines a branched DNA (bDNA) hybridization assay with upconversion nanoparticle (UCNP) labels to enhance the sensitivity of DNA detection. The anti‐Stokes emission of UCNP labels enables measurements without optical background interference. The bDNA assay relies on a series of oligonucleotide probes creating a branched structure with several binding sites for biotinylated amplification probes and streptavidin‐conjugated UCNPs. Several configurations of the bDNA assay are investigated to achieve the highest signal amplification and the lowest background signal. The optimal configuration of bDNA assay yields a limit of detection (LOD) of 5.9 × 104 cfu mL−1 for the target DNA of the bacteriophage M13. The upconversion‐linked bDNA assay is easily adaptable to other target DNAs by adjusting the oligonucleotide probes.
Graphene Microelectrode Arrays, 4D Structured Illumination Microscopy, and a Machine Learning Spike Sorting Algorithm Permit the Analysis of Ultrastructural Neuronal Changes During Neuronal Signaling in a Model of Niemann–Pick Disease Type C
Authors: Lu Meng , Hui Ernestine , Brockhoff Marius , Träuble Jakob , Fernandez‐Villegas Ana , Burton Oliver J , Lamb Jacob , Ward Edward , Woodhams Philippa J , Tadbier Wadood , Läubli Nino F , Hofmann Stephan , Kaminski Clemens F , Lombardo Antonio , Kaminski Schierle Gabriele S 
Published: September 2024

AbstractSimultaneously recording network activity and ultrastructural changes of the synapse is essential for advancing understanding of the basis of neuronal functions. However, the rapid millisecond‐scale fluctuations in neuronal activity and the subtle sub‐diffraction resolution changes of synaptic morphology pose significant challenges to this endeavor. Here, specially designed graphene microelectrode arrays (G‐MEAs) are used, which are compatible with high spatial resolution imaging across various scales as well as permit high temporal resolution electrophysiological recordings to address these challenges. Furthermore, alongside G‐MEAs, an easy‐to‐implement machine learning algorithm is developed to efficiently process the large datasets collected from MEA recordings. It is demonstrated that the combined use of G‐MEAs, machine learning (ML) spike analysis, and 4D structured illumination microscopy (SIM) enables monitoring the impact of disease progression on hippocampal neurons which are treated with an intracellular cholesterol transport inhibitor mimicking Niemann–Pick disease type C (NPC), and show that synaptic boutons, compared to untreated controls, significantly increase in size, leading to a loss in neuronal signaling capacity.
Fluid‐Infiltrated Metalens‐Driven Reconfigurable Intelligent Surfaces for Optical Wireless Communications
Authors: Khalid Ramna , Kim Jaekyung , Mahmood Nasir , Cabrera Humberto , Mehmood Muhammad Qasim , Danner Aaron , Zubair Muhammad , Rho Junsuk 
Published: September 2024

AbstractA reconfigurable intelligent surface (RIS), a leading‐edge technology, represents a new paradigm for adaptive control of electromagnetic waves between a source and a user. While RIS technology has proven effective in manipulating radio frequency waves using passive elements such as diodes and MEMS, its application in the optical domain is challenging. The main difficulty lies in meeting key performance indicators, with the most critical being accurate and self‐adjusting positioning. This work presents an alternative RIS design methodology driven by an all‐silicon structure and fluid infiltration, to achieve real‐time control of focal length toward a designated user, thereby enabling secure data transmission. To validate the concept, both numerical simulations and experimental investigations of the RIS design methodology are conducted to demonstrate the performance of fluid‐infiltrated metalens‐driven RIS for this application. When combined with different fluids, the resulting ultra‐compact RIS exhibits exceptional varifocal abilities, ranging from 0.4 to 0.5 mm, thereby confirming the adaptive tuning capabilities of the design. This may significantly enhance the modulation of optical waves and promote the development of RIS‐based applications in wireless communications and secure data‐transmission integrated photonic devices.
Decorated‐Induced Oxygen Vacancy Engineering for Ultra‐Low Concentration Nonanal Sensing: A Case Study of La‐Decorated Bi2O2CO3
Authors: Zheng Zichen , Liu Kewei , Zhou Yiwen , Xu Kaichun , Luo Yifan , Ding Jiabao , Bittencourt Carla , Debliquy Marc , Zhang Chao 
Published: September 2024

AbstractLa‐decorated Bi2O2CO3 (BCO‐La) microspheres are synthesized using a facile wet chemical strategy for sensing low‐concentration nonanal (C9H18O) at room temperature. These BCO‐La gas sensors are applied to evaluate agricultural product quality, specifically for cooked rice. The sensitivity of the BCO‐6La sensor significantly surpassed that of the pure BCO sensor, achieving a response value of 174.6 when detecting 30 ppm nonanal gas. Notably, the BCO‐6La sensor demonstrated a faster response time (36 s) when exposed to 18 ppm of nonanal. Additionally, the selectivity toward nonanal gas detection is higher (approximately 4–24 times) compared to interfering gases (1‐octanol, geranyl acetone, linalool, hexanal, 2‐pentyfuran, and 1‐octen‐3‐ol) during cooked rice quality detection. The gas sensing mechanism and the factors contributing to the enhanced sensing performance of the BCO‐La microspheres are demonstrated through in situ FT‐IR spectra and DFT analysis while the realistic detection scenario is carried out. In a broader context, the reported sensors here represent a novel platform for the detection and monitoring of gases released by agricultural products during storage.
Enhancing antibacterial photodynamic therapy with NIR‐activated gold nanoclusters: Atomic‐precision size effect on reducing bacterial biofilm formation and virulence
Authors: Liu Chengyu , Tian Tenghui , Shi Yujia , Li Meiqi , Hong Le , Zhou Jing , Liu Jia , Zhong Yuan , Wang Xue , Wang Zhenyu , Bai Xue , Wang Lin , Li Chunyan , Wu Zhennan 
Published: September 2024

AbstractPersistent biofilm infections pose a critical health threat with their relentless presence and amplified antibiotic resistance. Traditional antibacterial photodynamic therapy can inhibit bacteria extracellularly but struggles to control biofilm formation and virulence. Thus, there is an urgent need to develop photosensitizers, such as ultra‐small gold nanoclusters (AuNCs), that can penetrate biofilms and internalize into bacteria. However, AuNCs still face the challenge of insufficient reactive oxygen species (ROS) production and limited near‐infrared light absorption. This study develops a model of indocyanine green (ICG)‐sensitized AuNCs with atomic‐precision size effect. This approach achieved near‐infrared light absorption while inhibiting radiation transitions, thereby regulating the generation of ROS. Notably, different‐sized AuNCs (Au10NCs, Au15NCs, Au25NCs) yielded varied ROS types, resulting from different energy level distributions and electron transfer rates. ICG‐Au15NCs achieved a treatment efficacy of 99.94% against Staphylococcus aureus infections in vitro and significantly accelerated wound healing in vivo. Moreover, this study highlights the unique role of ICG‐AuNCs in suppressing quorum sensing, virulence, and ABC transporters compared to their larger counterparts. This strategy demonstrates that atomic‐precision size effect of AuNCs paves the way for innovative approaches in antibacterial photodynamic therapy for infection control.
Lessons learned from victimised adults in Taiwan: what does it mean to repair parent–child relationships?
Authors: Chang Hsiao‐Pei 
Published: September 2024

AbstractExposure to domestic violence can lead children to adopt specific roles or behaviours to cope with violent situations, which can have detrimental effects on their lives and require significant resources to address. Domestic violence can also severely damage the parent–child relationship. Adults who experienced childhood abuse often feel the need to repair these relationships, but the lack of trust in the abusive parent makes this process particularly challenging. This study aims to explore the subjective interpretations and experiences of victimised adults in Taiwan as they work to restore parent–child relationships following the cessation of domestic violence. Employing a hermeneutic phenomenological approach, the researcher conducted semi‐structured interviews with eight participants. Data analysis yielded three overarching themes related to the interpretation of restored parent–child relationships and eight themes pertaining to the experiences of restoring these relationships. These themes revealed that the core theme of the experience of restoring parent–child relationships among adults who experienced childhood abuse is ‘forgiveness and rebirth’. The study's findings emphasise that the restored parent–child relationship is not an ideal one but rather a relationship that acknowledges the limitations of both parents and children. It is a relationship where children can demonstrate filial piety without being undifferentiatedly obedient. In the context of Chinese culture, where relationships hold great significance, the researcher suggests that relational resilience serves as the driving force that enables family systems to progress towards relational wellbeing. Mental health practitioners must recognise and respect the client's cultural identity. When assisting adults who endured childhood domestic violence in mending their parent–child relationships, efforts should focus on fostering self‐in‐relation to promote their wellbeing.
Palaeohistology of Macrospondylus bollensis (Crocodylomorpha: Thalattosuchia: Teleosauroidea) from the Posidonienschiefer Formation (Toarcian) of Germany, with insights into life history and ecology
Authors: Johnson Michela M. , Scheyer Torsten M. , Canoville Aurore , Maxwell Erin E. 
Published: September 2024

AbstractThe Posidonienschiefer Formation of southern Germany has yielded an array of incredible fossil vertebrates. One of the best represented clades therein is Teleosauroidea, a successful thalattosuchian crocodylomorph group that dominated the coastlines. The most abundant teleosauroid, Macrospondylus bollensis, is known from a wide range of body sizes, making it an ideal taxon for histological and ontogenetic investigations. Previous studies examining thalattosuchian histology provide a basic understanding of bone microstructure in teleosauroids, but lack the taxonomic, stratigraphic, and ontogenetic control required to understand growth and palaeobiology within a species. Here, we examine the bone microstructure of three femora and one tibia from three different‐sized M. bollensis individuals. We also perform bone compactness analyses to evaluate for ontogenetic and ecological variation. Our results suggests that (1) the smallest specimen was a young, skeletally immature individual with well‐vascularized‐parallel‐fibered bone and limited remodeling in the midshaft periosteal cortex; (2) the intermediate specimen was skeletally immature at death, with vascularized parallel‐fibered bone tissue interrupted by at least 10 LAGs, but no clear external fundamental system (EFS), and rather extensive inner cortical bone remodeling; and (3) the largest specimen was skeletally mature, with parallel‐fibered bone tissue interrupted by numerous LAGs, a well‐developed EFS, and extensive remodeling in the deep cortex. Macrospondylus bollensis grew relatively regularly until reaching adult size, and global bone compactness values fall within the range reported for modern crocodylians. The lifestyle inference models used suggest that M. bollensis was well adapted for an aquatic environment but also retained some ability to move on land. Finally, both larger specimens display a peculiar, localized area of disorganized bone tissue interpreted as pathological.
Novel Carbohydrate Polymer‐Based Systems for Precise Drug Delivery in Colon Cancer: Improving Treatment Effectiveness With Intelligent Biodegradable Materials
Authors: Udaipuria Nikita , Bhattacharya Sankha 
Published: September 2024

ABSTRACTDue to their biocompatibility, biodegradability, and controlled release, carbohydrates polymers are crucial to targeted drug delivery systems, notably for colon cancer treatment. This article examines how carbohydrate polymers like chitosan, pectin, guar gum, alginate, hyaluronic acid, dextran, and chondroitin sulfate are used in improved drug delivery. Modifying these polymers improves drug loading, stability, and release patterns, enhancing chemotherapeutic drugs' therapeutic index. Chitosan nanoparticles are pH‐responsive, making them perfect for cancer treatment. Pectin's resistance to gastric enzymes and colonic bacteria makes it a promising colon‐specific medication delivery agent. The combination of these polymers with nanotechnology, 3D printing, and AI allows the creation of stimuli‐responsive systems that release drugs precisely in response to environmental signals like pH, redox potential, or colon enzymatic activity. The review highlights intelligent delivery system design advances that reduce systemic toxicity, improve treatment efficacy, and improve patient adherence. Carbohydrate polymers will revolutionize colon cancer treatment with personalized and accurate alternatives.
Machine learning integrated graphene oxide‐based diagnostics, drug delivery, analytical approaches to empower cancer diagnosis
Authors: Das Suparna , Mazumdar Hirak , Khondakar Kamil Reza , Kaushik Ajeet 
Published: September 2024

AbstractMachine learning (ML) and nanotechnology interfacing are exploring opportunities for cancer treatment strategies. To improve cancer therapy, this article investigates the synergistic combination of Graphene Oxide (GO)‐based devices with ML techniques. The production techniques and functionalization tactics used to modify the physicochemical characteristics of GO for specific drug delivery are explained at the outset of the investigation. GO is a great option for treating cancer because of its natural biocompatibility and capacity to absorb medicinal chemicals. Then, complicated biological data are analyzed using ML algorithms, which make it possible to identify the best medicine formulations and individualized treatment plans depending on each patient's particular characteristics. The study also looks at optimizing and predicting the interactions between GO carriers and cancer cells using ML. Predictive modeling helps ensure effective payload release and therapeutic efficacy in the design of customized drug delivery systems. Furthermore, tracking treatment outcomes in real time is made possible by ML algorithms, which permit adaptive modifications to therapy regimens. By optimizing medication doses and delivery settings, the combination of ML and GO in cancer therapy not only decreases adverse effects but also enhances treatment accuracy.
Sodium Alginate/Poly (Acrylicacid) Hydrogel Composite, Potential Carrier for Fibroblast Growth Factor1 (FGF1) Delivery
Authors: Sisakht Mahsa Mollapour , Gholizadeh Fatemeh , Shahravi Zahra , Doust‐Vaghe Yasaman Kiani , Nilforoushzadeh Mohammad Ali , Amirkhani Mohammad Amir 
Published: September 2024

AbstractFibroblast growth factor1 is a powerful signaling molecule that plays a critical role in injury repair of diverse tissue by stimulating cell growth and angiogenesis. FGF1 has significant role in the cell fate and regulating inflammation with short half‐life and poor in vivo stability. The encapsulation of the growth factor in the hydrogel led to peptide protect from the degradation and/or immune recognition and enable controlled drug delivery over a longer period of time. The aim of this study is to develop and evaluate a hydrogel carrier with adjustable release rate while maintaining bioactivity of FGF1. Here we describe an optimal ratio of sodium alginate and polyacrylic acid without additional cross linker containing optimum amount of FGF1 with the potential of sustained release to be used as a therapeutic agent. The carrier was characterized by FTIR, contact angle and swelling ratio. The activity of FGF1 after release from the hydrogel was confirmed by ELISA and Western blot. Further assessment of genes related to inflammation were evaluated by RTPCR. This hydrogel is able to deliver growth factors by restricting the essential proteins within the matrix to prevent rapid proteolysis and explosive release and is therefore widely applicable.
Aqueous Compatible Post‐Synthetic On‐Column Conjugation of Nucleic Acids Using Amino‐Modifiers
Authors: Saraya Jagandeep S. , Sammons Scott R. , O'Flaherty Derek K. 
Published: September 2024

AbstractNucleic acid conjugation methodologies involve linking the nucleic acid sequence to other (bio)molecules covalently. This typically allows for nucleic acid property enhancement whether it be for therapeutic purposes, biosensing, etc. Here, we report a streamlined, aqueous compatible, on‐column conjugation methodology using nucleic acids containing a site‐specific amino‐modifier. Both monophosphates and carboxylates were amenable to the conjugation strategy, allowing for the introduction of a variety of useful handles including azide, aryl, and hydrophobic groups in DNA. We find that an on‐column approach is superior to post‐synthetic template‐directed synthesis, mainly with respect to product purification and recovery.
Hemilabile Thio– and Selenoethers in Bis(benzimidazolyl)Amine Copper Complexes Relevant to the Active Sites of Copper‐Dependent Monooxygenases
Authors: Sánchez‐Eguía Brenda N. , Hernández‐Toledo Hugo , Lidin Sven , Flores‐Alamo Marcos , Nordlander Ebbe , Bertaina Sylvain , Orio Maylis , Castillo Ivan 
Published: September 2024

AbstractCopper complexes supported by benzimidazole‐based tetradentate neutral ligands featuring thio‐ and selenoether donors, resemble the coordination environment of the active site in copper dependent monooxygenases Dopamine‐β‐monooxygenase (DβM) and peptidylglycine‐α‐hydroxylating monooxygenase (PHM). The cuprous complexes react with O2 at low temperature generating a reactive copper‐oxygen species assigned to a side‐on cupric–superoxo complex, which activates the C─H bond of dihydroanthracene. Based on structural, 1H and 77Se NMR, and EPR spectroscopic characterization, together with DFT computations, the selenoether moiety likely acts as a hemilabile ligand in these scaffolds, which results in an electrophilic cupric–superoxide intermediate poised for H‐atom transfer, as has been proposed for related bis(benzimidazole)‐thioether analogues and selenoether‐modified enzymatic systems.