bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immune system dysfunction and inflammation in aging Shank3b mutant mice, a model of autism spectrum disorder
Authors: Cerilli Enrica , Dall’O Ginevra Matilde , Chelini Gabriele , Catena Benedetta , Weinberger Birgit , Bozzi Yuri , Pangrazzi Luca 
Published: September 2024

IntroductionAutism spectrum disorder (ASD) is a heterogeneous group of neurodevelopmental Q8 conditions characterized by deficits in social interaction/communication and restrictive/repetitive behaviors. Recent studies highlight the role of immune system dysfunction and inflammation in ASD pathophysiology. Indeed, elevated levels of pro-inflammatory cytokines were described in the brain and peripheral blood of ASD individuals. Despite this, how this pro-inflammatory profile evolves with aging and whether it may be associated with behavioral deficits is unknown. In this work, we explored the impact of aging on motor behavior and inflammation using Shank3b mutant mice, a model for syndromic ASD. MethodsUsing RT-qPCR and flow cytometry, we examined the expression of key pro-inflammatory molecules in the cerebellum, bone marrow, spleen, and peripheral blood, comparing adult and old Shank3b+/+, Shank3b+/-, and Shank3b-/- mice.Results and discussionOur findings revealed genotype- and age-related differences in inflammation and motor behavior, with Shank3b-/- mice exhibiting accelerated aging and motor impairments. Correlations between pro-inflammatory molecules and behavioral deficits suggest that a link may be present between systemic inflammation and ASD-related behaviors, underscoring the potential role of age-related inflammation (“inflammaging”) in exacerbating ASD symptoms.
Suppression of overactivated immunity in the early stage is the key to improve the prognosis in severe burns
Authors: Xiang Yang , Pan Bo-han , Zhang Jin , Chen Ji-qiu , Fang He , Wang Qun , Li Lin-hui , Chen Tian-sheng , Chen Jia-xin , Li Chan , Zheng Xing-feng , Zhu Shi-hui 
Published: September 2024

BackgroundSevere burns can lead to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) due to inflammation-immunity dysregulation. This study aimed to identify key immune-related molecules and potential drugs for immune regulation in severe burn treatment.MethodMicroarray datasets GSE77791 and GSE37069 were analyzed to identify immune-related differentially expressed genes (DEGs), enriched pathways and prognosis-related genes. The DGIdb database was used to identify potentially clinically relevant small molecular drugs for hub DEGs. Hub DEGs were validated by total RNA from clinical blood samples through qPCR. The efficacy of drug candidates was tested in a severe burn mouse model. Pathologic staining was used to observe organ damage. Enzyme Linked Immunosorbent Assay (ELISA) was used to detect the serum IL-1b, IL-6, TNF-a and MCP-1 contents. Activation of the NF-κB inflammatory pathway was detected by western blotting. Transcriptome sequencing was used to observe inflammatory-immune responses in the lung.ResultsA total of 113 immune-related DEGs were identified, and the presence of immune overactivation was confirmed in severe burns. S100A8 was not only significantly upregulated and identified to be prognosis-related among the hub DEGs but also exhibited an increasing trend in clinical blood samples. Methotrexate, which targets S100A8, as predicted by the DGIdb, significantly reduces transcription level of S100A8 and inflammatory cytokine content in blood, organ damage (lungs, liver, spleen, and kidneys) and mortality in severely burned mice when combined with fluid resuscitation. The inflammatory-immune response was suppressed in the lungs.ConclusionS100A8 with high transcription level in blood is a potential biomarker for poor severe burn prognosis. It suggested that methotrexate has a potential application in severe burn immunotherapy. Besides, it should be emphasized that fluid resuscitation is necessary for the function of methotrexate.
Behavioral, neurotransmitter and transcriptomic analyses in male and female Fmr1 KO mice
Authors: McCarthy Deirdre M. , Vied Cynthia , Trupiano Mia X. , Canekeratne Angeli J. , Wang Yuan , Schatschneider Christopher , Bhide Pradeep G. 
Published: September 2024

IntroductionFragile X syndrome is an inherited X-linked disorder associated with intellectual disabilities that begin in childhood and last a lifetime. The symptoms overlap with autism spectrum disorder, and the syndrome predominantly affects males. Consequently, FXS research tends to favor analysis of social behaviors in males, leaving a gap in our understanding of other behavioral traits, especially in females.MethodsWe used a mouse model of FXS to analyze developmental, behavioral, neurochemical, and transcriptomic profiles in males and females.ResultsOur behavioral assays demonstrated locomotor hyperactivity, motor impulsivity, increased “approach” behavior in an approach-avoidance assay, and deficits in nest building behavior. Analysis of brain neurotransmitter content revealed deficits in striatal GABA, glutamate, and serotonin content. RNA sequencing of the ventral striatum unveiled expression changes associated with neurotransmission as well as motivation and substance use pathways. Sex differences were identified in nest building behavior, striatal neurotransmitter content, and ventral striatal gene expression.DiscussionIn summary, our study identified sex differences in specific behavioral, neurotransmitter, and gene expression phenotypes and gene set enrichment analysis identified significant enrichment of pathways associated with motivation and drug reward.
Glymphatic system dysfunction associated with cognitive impairment in chronic tinnitus patients
Authors: Du Yinjuan , Huang Zhichun , Wu Yuanqing , Xue Yuan , Che Zigang 
Published: September 2024

BackgroundThe glymphatic system has been regarded as a pivotal factor in the pathogenesis of neurodegenerative diseases. Given the heightened risk of cognitive impairment in chronic tinnitus patients, the possible alterations of the glymphatic system in tinnitus patients remain elusive. This study was designed to evaluate glymphatic dysfunction in chronic tinnitus patients using the diffusion tensor imaging (DTI) along the perivascular space (DTI-ALPS) approach.MethodsFifty chronic tinnitus patients and 50 age, sex, and education-matched healthy controls (HCs) with normal hearing thresholds were recruited. The DTI-ALPS was calculated from each group. We investigated the differences in the DTI-ALPS index between the tinnitus patients and HCs. The relationships between the DTI-ALPS index and specific cognitive performance were further assessed.ResultsThere were significant differences in the DTI-ALPS index between the two groups. The DTI-ALPS index was significantly lower in the tinnitus group than in HCs group (p &lt; 0.01). In addition, the Dyyproj index was significantly higher in the tinnitus group than in the HC group (p &lt; 0.01). In chronic tinnitus patients, the decreased DTI-ALPS index was negatively associated with worse TMT-B scores (r = −0.309, p = 0.039). Moreover, the increased Dyyproj index was negatively correlated with the reduced AVLT performances (r = −0.413, p = 0.005).ConclusionIn this current study, glymphatic system activity in chronic tinnitus was investigated for the first time using DTI-ALPS index. Significant decrease in glymphatic system function was detected in chronic tinnitus, which correlated well with the specific cognitive performance. The current study may provide pivotal imaging markers for chronic tinnitus with cognitive impairment.
Effects of intermittent seating upright, lower body negative pressure, and exercise on functional tasks performance after head-down tilt bed rest
Authors: Clément Gilles , Moudy Sarah C. , Macaulay Timothy R. , Mulder Edwin , Wood Scott J. 
Published: September 2024

IntroductionBed rest can be used as a ground-based analog of the body unloading associated with spaceflight. In this study, we determined how strict head-down tilt bed rest affects subjects’ performance of functional tests (sit-to-stand, tandem walk, walk-and-turn, dynamic posturography) that challenge astronauts’ balance control systems immediately after they return from space.MethodsForty-seven participants were assessed before and a few hours after 30 days of 6° head down tilt bed rest at the DLR:envihab facility. During this bed rest study, called SANS-CM, the participants were divided into 4 groups that either a) were positioned in head-down tilt continuously throughout the 30 days; b) sat upright for 6 h a day; c) were exposed to lower body negative pressure (LBNP) for 6 h a day; or d) exercised for 60 min and then wore venous-occlusive cuffs for 6 h a day.ResultsResults showed that strict head-down tilt bed rest caused deficits in performance of functional tasks that were similar to those observed in astronauts after spaceflight. Seated upright posture mitigated these deficits, whereas exercise or LBNP and cuffs partly mitigated them.DiscussionThese data suggest that more direct, active sensorimotor-based countermeasures may be necessary to maintain preflight levels of functional performance after a long period of body unloading.
Validation of the French version of the Body Awareness Questionnaire: toward a way to assess alexisomia
Authors: Carre Arnaud , Shankland Rebecca , Guillaume Philippe , Duclos Jeanne , El-Jor Claire , Pellissier Sonia , Flaudias Valentin 
Published: September 2024

BackgroundAwareness of one's own states is a particularly important part of cognition and emotion regulation. Recently, the concept of alexisomia has been used to refer to lack of awareness and expression of somatic sensations. Developing self-reported questionnaires to evaluate alexisomia represents a challenge for clinical psychology and medicine. In this context, we suggested to adapt the Body Awareness Questionnaire in French to measure alexisomia and its relation to alexithymia. In fact, we carried out a backtranslation and studied the validity of the construct in relation to proximal constructs around emotional awareness.MethodsFor this study, 610 university students completed questionnaires measuring a three dimensions alexithymia concept [with The Toronto Alexithymia Scale (TAS-20)] or the five dimensions alexithymia concept [with The Bermond-Vorts Alexithymia Questionnaire (BVAQ-B)] and alexisomia (with the BAQ).ResultsConfirmatory factor analyses showed that the BAQ can be envisaged through 4 factors as well as a unidimensional model to refer to alexisomia. We also found that body awareness was negatively related to scores of alexithymia.ConclusionResults are discussed in light of the construct of alexisomia and its clinical implications in somatic as well as mental disorders. We suggest that the BAQ, which assesses interoception, can contribute, in part, to the assessment of alexisomia. Like alexithymia, this is a key concept to take into consideration when designing treatment and prevention programs.
Community and family relationships across the transition to medical school: links to student adjustment
Authors: Rincon Brenda , Bravo Diamond Y. , Arnold Elisha , Meza Alexis , Camacho-Thompson Daisy 
Published: September 2024

IntroductionSupporting students during the transition to medical school is crucial for their academic adjustment. However, there has been limited research on the protective role of community and family support during this transition, despite evidence of the benefits of supportive relationships in higher education. Guided by self-determination theory, the current cross-sectional study explored how changes in family and community relationships impact Cuban medical students' sense of belonging in their field and their grade expectations.MethodsA total of 881 medical students (MAge = 21.51, SD= 2.23, range = 18–33; 54% female; 72.2% Cuban) participated in this study. Participants included students across 6 years of medical school (1st year = 14.8%, 2nd year = 10%, 3rd year = 24.1%, 4th year = 19.3%, 5th year = 11.8%, 6th year = 20%).ResultsControlling for key demographics (e.g., student aid experience, family legacy, nationality, year in medical school, prior academic performance, gender, and offspring), our findings revealed that improvements in community relationships—rather than family relationships—were associated with higher levels of field belonging. Additionally, more extensive experience as a student aid and a greater number of family members with a medical background were linked to higher levels of field belonging and higher grade expectations. Notably, higher prior academic performance was associated with increased field belonging but did not affect grade expectations. Conversely, identifying as female was related to both higher field belonging and higher grade expectations.DiscussionOur study highlights the importance of supportive community relationships for medical students' academic adjustment. We discuss the potential benefits of enhancing community relationships within medical school training programs.
Effect of music therapy on anxiety in full-term pregnant women
Authors: Ji Chao , Li Juan , Nie Qiaole , Wang Shuo 
Published: September 2024

ObjectivesTo examine the impact of receptive music therapy on maternal anxiety both during and after the process of childbirth.MethodsIn this experimental study, 217 women were divided into the receptive music therapy and control groups. The first group were exposed to music at intervals of 20 minutes for a duration of 30 minutes during labor. Data were collected using the Pregnant Information Form, the State Anxiety Inventory (STAI), Visual Analogue Scale and Edinburgh postnatal depression scale.ResultsThe pregnant women who participated in the music group exhibited reduced scores of STAI, both during the active time (46.42 ± 11.69 vs. 50.21 ± 11.14, 44.37 ± 10.38 vs. 47.56 ± 11.46, P&lt;0.05) and two hours after giving birth(26.32 ± 6.23 vs. 29.55 ± 8.9, 30.38 ± 7.15 vs. 33.08 ± 9.45, P&lt;0.05). At the first stage of labor, pregnant women in the music group experienced dramatically reduced score of pain in active phase (6.39 ± 1.00 vs. 6.91 ± 0.99, P&lt;0.05) and Edinburgh postnatal depression scale at discharged from the hospital (6.68 ± 3.36 vs. 7.66 ± 3.54, P&lt;0.05).ConclusionReceptive music therapy is effective in reducing pain during labor and anxiety during prenatal and postnatal periods. The use of receptive music therapy in obstetric care can be an effective tool in preventing anxiety-induced complications.
Regional differences, dynamic evolution, and influencing factors of high-quality medical resources in China’s ethnic minority areas
Authors: Liang Binghua , Huang Lifeng , Chen Zhuo , Hao Bangyan , Li Chengcheng 
Published: September 2024

BackgroundIn China, as people’s standard of living improves and the medical service system becomes more sophisticated, the demand for higher-quality and improved healthcare services is steadily rising. Inequality in health resource allocation (HRA) is more pronounced in ethnic minority areas (EMAs) than in developed regions. However, little research exists on high-quality medical resources (HQMRs) in China’s EMAs. Hence, we examined the spatiotemporal dynamic evolution of HQMRs in China’s EMAs from 2007 to 2021 and identified the main factors affecting their respective HQMR levels.MethodsWe selected tertiary hospitals to represent the quality of healthcare resources. We employed descriptive statistical techniques to analyze changes in the distribution of HQMRs from 2007 to 2021. We used the Dagum Gini coefficient and kernel density approach to analyze the dynamic evolution of HQMRs in China’s EMAs. We utilized the least squares dummy variable coefficient (LSDVC) to identify key factors affecting HQMR.ResultsThe number of HQMRs in each EMA has risen annually. The average number of tertiary hospitals increased from 175 in 2007 to 488 in 2021. The results of the Dagum Gini coefficient revealed that the differences in the HQMR level in China’s EMAs have slowly declined, and intra-regional disparities have now become the primary determining factor influencing overall variations. The kernel density plot indicated that the HQMR level improved significantly during the study period, but bifurcation became increasingly severe. Using the LSDVC for analysis, we found that gross domestic product (GDP) per capita, the size of the resident population, and the number of students enrolled in general higher education exhibited a significant negative correlation with HQMR levels, while GDP and urbanization rate had a significant promoting effect.ConclusionThe HQMR level in EMAs has risen rapidly but remains inadequate. The differences in HQMR between regions have continued to narrow, but serious bifurcation has occurred. Policymakers should consider economic growth, education, and population size rather than simply increasing the number of HQMRs everywhere.
PERILAKU BULLYING DITINJAU DARI KOMUNIKASI INTERPERSONAL ORANG TUA-ANAK DAN KONTROL DIRI
Authors: Fikrina Luthfa rizanatul , Putri Siska Adinda Prabowo , Argasiam Brigitan 
Published: September 2024

This study aims to examine the relationship interpersonal communication between parent-child and self-control towards bullying behavior in early adolescents in Dororejo Village, Doro District, Pekalongan Regency. The subjects of this study were early adolescents spread across 5 schools in Doro District, Pekalongan Regency, totaling 270 students. The research sampling technique was simple random sampling. This research uses Multiple Linear Regression Test and correlation product moments as data analysis. The research instrument was a bullying behavior scale based on Darmawan's theory, a parent-child interpersonal communication scale based on DeVito's theory and a self-control scale based on Averill's theory. The results showed a relationship between interpersonal communication and self-control towards bullying behavior, which was indicated by R = 0.293, R square = 0.086, F regression = 12.977, p = 0.000 (p <0.001). In addition, it was also found that parent-child interpersonal communication had a negative and significant effect on bullying behavior as indicated by the value of rx1y = -0.245 (p<0.001) and also self-control has a negative and significant effect on bullying behavior as indicated by the value of rx2y = -0,257 ( p <0, 001).
HARGA DIRI DAN KOHESIVITAS KELOMPOK TERHADAP SOCIAL LOAFING PADA MAHASISWA FBB UNTAG 1945 SEMARANG
Authors: Agata Grace , Hariadi Lucy , Arum Permitasari I Rheny 
Published: September 2024

Social loafing is an intriguing problem, especially among students, because group members frequently rely on one another without providing appropriate contributions. This study aims to examine the relationship between Self-Esteem and Group Cohesiveness on Social Loafing among students at the Faculty of Language and Culture at Seventeen August University, Semarang. Quantitative correlation is utilized to collect and analyze data on 188 students. The variable Self-Esteem (X1) has a t-value of -2,317 and a significance level of 0.019, so the null hypothesis (H1) is accepted. Thus, Self-Esteem (X1) has a negative relationship with Social Loafing (Y). In the meantime, the Group Cohesiveness (X2) variable has a t value of -3,562 and a significance level of 0.000, so H2 is also accepted. This demonstrates that Group Cohesiveness (X2) has a negative and statistically significant relationship with Social Loafing (Y). They simultaneously have an F value of 11.243 and a significance value of 0.000. This indicates that H3 is accepted, which means that Self-Esteem (X1) and Group Cohesion (X2) simultaneously influence Social Loafing (Y).
Impact of Social Media Marketing on Brand Loyalty in Chinese Local Cosmetics Industry: The Mediating Role of Customer Engagement
Authors: Liu Yingxi , Inmor Sureerut , Wongpun Sukontip 
Published: September 2024

The enduring global popularity of social media and the emergence of the “Guochao” trend in China have compelled businesses to rethink traditional marketing concepts and implement more effective marketing techniques. This study aimed to explore how social media marketing (SMM) affects brand loyalty in the Chinese local cosmetics industry. Data from 468 Chinese local cosmetics customers were analyzed by using structural equation modeling. The findings indicate that social media influencer marketing (SMIM) and content marketing (CM) have direct positive impacts on customer brand loyalty (BL). Customer engagement (CE) mediates the effects of SMIM and CM on BL. The research findings emphasize the importance of the power of social media influencers (SMIs) and content value in driving CE and fostering BL. They should utilize SMIs who align with the brand's characteristics and create content that resonates with consumers, thereby attracting potential consumers and establishing brand loyalty. Chinese consumers are more inclined to be influenced by genuine and charismatic SMIs. While Chinese market prefers practical and persuasive content over entertaining content, Chinese local cosmetics should focus on publishing content with practical value and problem-solving capabilities, such as usage tips, skincare knowledge. Moreover, the importance of CE is emphasized, suggesting that marketers of Chinese local cosmetics brands capitalize on the trend of traditional culture revival when formulating marketing strategies. Integrating information related to traditional Chinese medicine or ethnic craftsmanship may further encourage consumers to engage more deeply and enhance their loyalty.

Received: 27 March 2024 / Accepted: 29 August 2024 / Published: 05 September 2024
Legal Protection For Victims Of Misuse Of Personal Data When Making Online Loans
Authors: Sandika Arabin , Zainuddin Cholidi , Wardhana Arief Wisnu 
Published: September 2024

Current developments are investments that take advantage of the digital era and globalization using application products, namely financial technology (Omarova, 2020). Financial technology is a combination of financial services and technology that makes changes to businesses that were previously conventional to become modern. Then, with modern technology, things are illegal and use other people's data. This research method uses normative juridical or doctrinal juridical research. The formulation of the problem is legal protection for victims of misuse of personal data when making online loans. The result is that legal protection can take the form of civil legal protection, criminal legal protection. Including those contained in the Financial Services Authority (OJK) regulations, however, this legal instrument does not yet comprehensively regulate the misuse of personal data for online loans.. Keywords: personal data; victim; legal protection; abuse; online loans.