bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multi-analytical approach to understand and predict the mobile commerce adoption
Authors: Yadav Rajan , Sharma Sujeet Kumar , Tarhini Ali 
Published: February 2016

Purpose
– The advent of mobile telephony devices with strong internet capabilities has laid the foundation for mobile commerce (m-commerce) services. The purpose of this paper is to empirically examine predictors of m-commerce adoption using a modification of the widely used technology acceptance model and the unified theory of acceptance and use of technology model.

Design/methodology/approach
– The data were collected from 213 respondents by means of an online survey. The data were analyzed through multi analytic approach by employing structural equation modeling (SEM) and neural network modeling.

Findings
– The SEM results showed that variety of services, social influence, perceived usefulness, cost and perceived trust have significant influence on consumer’s intention to adopt m-commerce. The only exception was perceived ease of use which observed statistically insignificant influence on adoption of m-commerce. Furthermore, the results obtained from SEM were employed as input to the neural network model and results showed that perceived usefulness, perceived trust and variety of services as most important predictors in adoption of m-commerce.

Practical implications
– The findings of this study give an insight of key determinants that are important to develop suitable strategic framework to enhance the use of m-commerce adoption. In addition, it also provides an opportunity to academicians and researchers to use the framework of this study for further research.

Originality/value
– The study is among a very few studies which analyzed m-commerce adoption by applying a linear and non-linear approach. The study offers a multi-analytical model to understand and predict m-commerce adoption in the developing nation like India.
High performance work systems, employee well-being, and job involvement: an empirical study
Authors: Huang Liang-Chih , Ahlstrom David , Lee Amber Yun-Ping , Chen Shu-Yuan , Hsieh Meng-Jung 
Published: February 2016

Purpose– Given the importance of high performance work systems (HPWS) with respect to firm competitive advantage, this paper holds that the contribution of HPWS toward the desired outcomes for organizations may depend significantly on employee job involvement. Underpinning the argument of happy workers being productive, the purpose of this paper is to propose the critical mediator of employee well-being to explain the hypothesized multilevel relationship between HPWS and job involvement.Design/methodology/approach– The authors distributed questionnaires to the target participants. Data collected from 451 employees and 50 HR managers/professionals of 50 firms in the three major industrial categories of manufacturing, finance, and service in Taiwan.Findings– This study identifies the significance of employee well-being by incorporating the theories of planned behavior and positive psychology and provides empirical evidence for the cross-level influence of HPWS on employee well-being and job involvement.Originality/value– This study incorporates the perspective of positive psychology as an important addition to research on SHRM and performance by highlighting employee well-being as a key mediator of SHRM and job involvement.
The role of privacy invasion and fairness in understanding job applicant reactions to potentially inappropriate/discriminatory interview questions
Authors: Ababneh Khaldoun I. , Al-Waqfi Mohammed A. 
Published: February 2016

Purpose
– Building on organizational justice and privacy literatures, the purpose of this paper is to test a model capturing the impacts of potentially inappropriate/discriminatory interview questions on job applicant perceptions and behavioral intentions in a developing economy context with a multicultural workforce.

Design/methodology/approach
– An experimental design using senior undergraduate students (n=221) seeking or about to seek jobs in the United Arab Emirates was used to examine interviewees’ reactions to inappropriate/discriminatory interview questions. A questionnaire was used to collect the data. Structural equation modeling and bootstrapping were used for data analysis and hypothesis testing.

Findings
– This study demonstrates that inappropriate/discriminatory interview questions influence privacy invasion perceptions, which in turn influence job applicants’ fairness perceptions and behavioral intentions. This study also demonstrates that privacy invasion perceptions fully mediate the effect of inappropriate/discriminatory employment interview questions on fairness perceptions. Moreover, the findings show that privacy invasion directly and indirectly, via fairness perceptions, influence litigation intentions. On the other hand, findings of this study indicate that privacy invasion influence organizational attractiveness and recommendation intentions only indirectly, via fairness perceptions.

Originality/value
– This is the first study to examine the impact of inappropriate/discriminatory interview questions on applicant reactions in a developing economy context with social, cultural, and legal environment that is different from those prevailing in developed Western societies. This study demonstrates that privacy invasion is an important mechanism to understand job applicant reactions to inappropriate interview questions.
Role of Fanconi anemia/BRCA pathway genes in hepatocellular carcinoma chemoresistance
Authors: Ferroudj Sana , Yildiz Gokhan , Bouras Mourad , Iscan Evin , Ekin Umut , Ozturk Mehmet 
Published: February 2016

AimTo investigate the expression of DNA repair genes and the impact of the breast cancer 1, early onset (BRCA1) protein on chemoresistance of hepatocellular carcinoma (HCC).MethodsMicroarray gene expression datasets were analyzed using the gene set enrichment analysis method. BRCA1 protein was tested by Western blotting. Response of HCC cells to interstrand cross‐links was investigated by cell viability assay following exposure to mitomycin C, cisplatin, and melphalan. Effects of BRCA1 ectopic expression were studied in HepG2 cells with BRCA1‐expression plasmids. Effects of BRCA1 downregulation were studied in SNU449 cells with BRCA1‐specific siRNAs. Response of transfected SNU449 cells to mitomycin C was analyzed by cell viability tests and cell cycle analysis using flow cytometry.ResultsExpression of Fanconi anemia and double‐stranded DNA break repair genes was significantly upregulated in HCC tumors. This upregulation displayed a gradual amplification during tumor progression. BRCA1 and BRCA2 genes were among consistently upregulated genes. Epithelial‐like HCC cells had low BRCA1 expression and low chemoresistance, whereas mesenchymal‐like HCC cells had high BRCA1 expression and increased chemoresistance. Ectopic expression of BRCA1 increased the chemoresistance of epithelial‐like HepG2 cells. Conversely, BRCA1 knockdown chemosensitized mesenchymal‐like SNU449 cells. Chemosensitization of SNU449 cells was due to cell cycle arrest at 4N stage.ConclusionIncreased expression of Fanconi anemia and double‐stranded DNA repair genes such as BRCA1 is a novel mechanism of HCC chemoresistance. However, functional inactivation of BRCA1 expression is sufficient to reverse such chemoresistance.
Systematic feasibility analysis of a quantitative elasticity estimation for breast anatomy using supine/prone patient postures
Authors: Hasse Katelyn , Neylon John , Sheng Ke , Santhanam Anand P. 
Published: February 2016

Purpose:Breast elastography is a critical tool for improving the targeted radiotherapy treatment of breast tumors. Current breast radiotherapy imaging protocols only involve prone and supine CT scans. There is a lack of knowledge on the quantitative accuracy with which breast elasticity can be systematically measured using only prone and supine CT datasets. The purpose of this paper is to describe a quantitative elasticity estimation technique for breast anatomy using only these supine/prone patient postures. Using biomechanical, high‐resolution breast geometry obtained from CT scans, a systematic assessment was performed in order to determine the feasibility of this methodology for clinically relevant elasticity distributions.Methods:A model‐guided inverse analysis approach is presented in this paper. A graphics processing unit (GPU)‐based linear elastic biomechanical model was employed as a forward model for the inverse analysis with the breast geometry in a prone position. The elasticity estimation was performed using a gradient‐based iterative optimization scheme and a fast‐simulated annealing (FSA) algorithm. Numerical studies were conducted to systematically analyze the feasibility of elasticity estimation. For simulating gravity‐induced breast deformation, the breast geometry was anchored at its base, resembling the chest‐wall/breast tissue interface. Ground‐truth elasticity distributions were assigned to the model, representing tumor presence within breast tissue. Model geometry resolution was varied to estimate its influence on convergence of the system. A priori information was approximated and utilized to record the effect on time and accuracy of convergence. The role of the FSA process was also recorded. A novel error metric that combined elasticity and displacement error was used to quantify the systematic feasibility study. For the authors' purposes, convergence was set to be obtained when each voxel of tissue was within 1 mm of ground‐truth deformation.Results:The authors' analyses showed that a ∼97% model convergence was systematically observed with no‐a priori information. Varying the model geometry resolution showed no significant accuracy improvements. The GPU‐based forward model enabled the inverse analysis to be completed within 10–70 min. Using a priori information about the underlying anatomy, the computation time decreased by as much as 50%, while accuracy improved from 96.81% to 98.26%. The use of FSA was observed to allow the iterative estimation methodology to converge more precisely.Conclusions:By utilizing a forward iterative approach to solve the inverse elasticity problem, this work indicates the feasibility and potential of the fast reconstruction of breast tissue elasticity using supine/prone patient postures.
Contribution of Walking to School to Individual and Population Moderate-Vigorous Intensity Physical Activity: Systematic Review and Meta-Analysis
Authors: Martin Anne , Kelly Paul , Boyle Jessica , Corlett Fenella , Reilly John J. 
Published: February 2016

Purpose:This study estimated the contribution of walking to/from school to objectively measured daily moderate-vigorous intensity physical activity (MVPA) in individuals and populations.Methods:MEDLINE, PsycINFO and SPORTDiscus were systematically searched up to February 2015. Two reviewers independently screened titles/abstracts/full-text articles, and assessed study quality.Results:Of 2430 records, 129 were eligible for full-text screening. Twelve studies met the inclusion criteria of reporting objectively obtained measures of MVPA (total and while walking to/from school) in children and adolescents. The weighted mean MVPA accumulated in walking to and from school was 17 min/day in primary school pupils (9 samples, n = 3422) and 13 min/day in high school pupils (4 samples, n = 2600). Pooled analysis suggested that walking to and from school contributed 23% and 36% of MVPA on schooldays in primary school age children and high school pupils, respectively. All included studies were of high methodological quality.Conclusions:Walking to and from school makes a meaningful contribution to individual schoolday MVPA for active commuters in western countries. Since schooldays represent only around half of all days, and prevalence of walking to school is low in many countries, the contribution of walking to school to population MVPA is probably low.
Clinical and Epidemiological Significance of Carbapenem Resistance in Acinetobacter baumannii Infections
Authors: Tal-Jasper Ruthy , Katz David E. , Amrami Nadav , Ravid Dor , Avivi Dori , Zaidenstein Ronit , Lazarovitch Tsilia , Dadon Mor , Kaye Keith S. , Marchaim Dror 
Published: February 2016

ABSTRACT

Carbapenems are considered the treatment of choice for
Acinetobacter baumannii
infections. Many facilities implement preventive measures toward only carbapenem-resistant
A. baumannii
(CRAB). However, the independent role of the carbapenem resistance determinant on patient outcomes remains controversial. In a 6-year analysis of adults with
A. baumannii
bloodstream infection (BSI), the outcomes of 149 CRAB isolates were compared to those of 91 patients with carbapenem-susceptible
A. baumannii
. In bivariable analyses, CRAB BSIs were significantly associated with worse outcomes and with a delay in the initiation of appropriate antimicrobial therapy (DAAT). However, in multivariable analyses, carbapenem resistance status was no longer associated with poor outcomes, while DAAT remained an independent predictor. The epidemiological significance of
A. baumannii
should not be determined by its resistance to carbapenems.
A New Antileishmanial Preparation of Combined Solamargine and Solasonine Heals Cutaneous Leishmaniasis through Different Immunochemical Pathways
Authors: Lezama-Dávila C. M. , McChesney J. D. , Bastos J. K. , Miranda M. A. , Tiossi R. F. , da Costa J. de C. , Bentley M. V. , Gaitan-Puch S. E. , Isaac-Márquez A. P. 
Published: February 2016

ABSTRACT

Little has been done during the past 100 years to develop new antileishmanial drugs. Most infected individuals live in poor countries and have a low cash income to be attractive targets to pharmaceutical corporations. Two heterosidic steroids, solamargine and solasonine, initially identified as major components of the Brazilian plant
Solanum lycocarpum
, were tested for leishmanicidal activity. Both alkaloids killed intracellular and extracellular
Leishmania mexicana
parasites more efficiently than the reference drug sodium stibogluconate. A total of 10 μM each individual alkaloid significantly reduced parasite counts in infected macrophages and dendritic cells.
In vivo
treatment of C57BL/6 mice with a standardized topical preparation containing solamargine (45.1%) and solasonine (44.4%) gave significant reductions in lesion sizes and parasite counts recovered from lesions. Alkaloids present different immunochemical pathways in macrophages and dendritic cells. We conclude that this topical preparation is effective and a potential new and inexpensive treatment for cutaneous leishmaniasis.
Experimental Models of Vaginal Candidiasis and Their Relevance to Human Candidiasis
Authors: Cassone Antonio , Sobel Jack D. 
Published: February 2016

ABSTRACT
Vulvovaginal candidiasis (VVC) is a high-incidence disease seriously affecting the quality of life of women worldwide, particularly in its chronic, recurrent forms (RVVC), and with no definitive cure or preventive measure. Experimental studies in currently used rat and mouse models of vaginal candidiasis have generated a large mass of data on pathogenicity determinants and inflammation and immune responses of potential importance for the control of human pathology. However, reflection is necessary about the relevance of these rodent models to RVVC. Here we examine the chemical, biochemical, and biological factors that determine or contrast the forms of the disease in rodent models and in women and highlight the differences between them. We also appeal for approaches to improve or replace the current models in order to enhance their relevance to human infection.
A Functional Core of IncA Is Required for Chlamydia trachomatis Inclusion Fusion
Authors: Weber Mary M. , Noriea Nicholas F. , Bauler Laura D. , Lam Jennifer L. , Sager Janet , Wesolowski Jordan , Paumet Fabienne , Hackstadt Ted 
Published: February 2016

ABSTRACT

Chlamydia trachomatis
is an obligate intracellular pathogen that is the etiological agent of a variety of human diseases, including blinding trachoma and sexually transmitted infections. Chlamydiae replicate within a membrane-bound compartment, termed an inclusion, which they extensively modify by the insertion of type III secreted proteins called Inc proteins. IncA is an inclusion membrane protein that encodes two coiled-coil domains that are homologous to eukaryotic SNARE (soluble
N
-ethylmaleimide-sensitive factor attachment receptor) motifs. Recent biochemical evidence suggests that a functional core, composed of SNARE-like domain 1 (SLD-1) and part of SNARE-like domain 2 (SLD-2), is required for the characteristic homotypic fusion of
C. trachomatis
inclusions in multiply infected cells. To verify the importance of IncA in homotypic fusion in
Chlamydia
, we generated an
incA
::
bla
mutant. Insertional inactivation of
incA
resulted in the formation of nonfusogenic inclusions, a phenotype that was completely rescued by complementation with full-length IncA. Rescue of homotypic inclusion fusion was dependent on the presence of the functional core consisting of SLD-1 and part of SLD-2. Collectively, these results confirm
in vitro
membrane fusion assays identifying functional domains of IncA and expand the genetic tools available for identification of chlamydia with a method for complementation of site-specific mutants.

IMPORTANCE
Chlamydia trachomatis
replicates within a parasitophorous vacuole termed an inclusion. The chlamydial inclusions are nonfusogenic with vesicles in the endocytic pathway but, in multiply infected cells, fuse with each other to form a single large inclusion. This homotypic fusion is dependent upon the presence of a chlamydial inclusion membrane-localized protein, IncA. Specificity of membrane fusion in eukaryotic cells is regulated by SNARE (soluble
N
-ethylmaleimide sensitive factor attachment receptor) proteins on the cytosolic face of vesicles and target membranes. IncA contains two SNARE-like domains. Newly developed genetic tools for the complementation of targeted mutants in
C. trachomatis
are used to confirm the minimal requirement of SNARE-like motifs necessary to promote the homotypic fusion of inclusions.
Immune Homeostatic Macrophages Programmed by the Bacterial Surface Protein NhhA Potentiate Nasopharyngeal Carriage of Neisseria meningitidis
Authors: Wang Xiao , Sjölinder Mikael , Gao Yumin , Wan Yi , Sjölinder Hong 
Published: February 2016

ABSTRACTNeisseria meningitidiscolonizes the nasopharyngeal mucosa of healthy populations asymptomatically, although the bacterial surface is rich in motifs that activate the host innate immunity. What determines the tolerant host response to this bacterium in asymptomatic carriers is poorly understood. We demonstrated that the conserved meningococcal surface protein NhhA orchestrates monocyte (Mo) differentiation specifically into macrophage-like cells with a CD200Rhiphenotype (NhhA-Mφ). In response to meningococcal stimulation, NhhA-Mφ failed to produce proinflammatory mediators. Instead, they upregulated interleukin-10 (IL-10) and Th2/regulatory T cell (Treg)-attracting chemokines, such as CCL17, CCL18, and CCL22. Moreover, NhhA-Mφ were highly efficient in eliminating bacteria. Thein vivovalidity of these findings was corroborated using a murine model challenged withN. meningitidissystematically or intranasally. The NhhA-modulated immune response protected mice from septic shock; Mo/Mφ depletion abolished this protective effect. Intranasal administration of NhhA induced an anti-inflammatory response, which was associated withN. meningitidispersistence at the nasopharynx.In vitrostudies demonstrated that NhhA-triggered Mo differentiation occurred upon engaged Toll-like receptor 1 (TLR1)/TLR2 signaling and extracellular signal-regulated kinase (ERK) and Jun N-terminal protein kinase (JNK) activation and required endogenously produced IL-10 and tumor necrosis factor alpha (TNF-α). Our findings reveal a strategy that might be adopted byN. meningitidisto maintain asymptomatic nasopharyngeal colonization.IMPORTANCENeisseria meningitidisis an opportunistic human-specific pathogen that colonizes the nasopharyngeal mucosa asymptomatically in approximately 10% of individuals. Very little is known about how this bacterium evades immune activation during the carriage stage. Here, we observed thatN. meningitidis, via the conserved surface protein NhhA, skewed monocyte differentiation into macrophages with a CD200Rhiphenotype. Bothin vivoandin vitrodata demonstrated that these macrophages, upon meningococcal infection, played an important role in forming a homeostatic immune microenvironment through their capacity to eliminate invading bacteria and to generate anti-inflammatory mediators. This work provides novel insight into the mechanisms underlying the commensal persistence ofN. meningitidis.
Evaluation of Factors Associated with Night Pain in Women Undergoing Carpal Tunnel Release
Authors: Kim Jeong Hwan , Gong Hyun Sik , Cho Hoyune Esther , Park Jin Woo , Kim Jihyeung , Baek Goo Hyun 
Published: February 2016

Background: Night pain has important diagnostic and prognostic values in patients with carpal tunnel syndrome (CTS). We aimed to determine whether night pain is associated with certain patient characteristics in female patients undergoing carpal tunnel release. Methods: We recruited 75 women with the mean age of 54 years who were scheduled for carpal tunnel release. Diagnosis of CTS was made based on both the clinical symptoms and the results of electrophysiologic studies. Patient characteristics investigated as factors potentially associated with night pain were: age, body mass index (BMI), symptom duration, comorbidities such as diabetes mellitus (DM) and thyroid disease, electrophysiologic severity of CTS, and sleep position. We conducted a logistic regression analysis to examine the relationships between the presence of night pain and the different patients' demographic and clinical variables. Results: Absence of night pain was associated with increased age (odds ratio (OR), 0.918, 95% confidence interval (CI), 0.851 to 0.99) and presence of DM (OR, 0.196; 95% CI, 0.046 to 0.835). The other variables assessed were not found to be associated with presence or absence of night pain. Conclusions: This study found that in women undergoing carpal tunnel release, older patients or those having DM are slightly less likely to have night pain. As night pain is an important prognostic factor for CTS, further studies are warranted to determine whether the absence of night pain could affect outcome assessment of CTS in the elderly or patients with DM.