bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease
Authors: Vlassenko Andrei G. , McCue Lena , Jasielec Mateusz S. , Su Yi , Gordon Brian A. , Xiong Chengjie , Holtzman David M. , Benzinger Tammie L. S. , Morris John C. , Fagan Anne M. 
Published: July 2016

ObjectiveDeposition of amyloid β (Aβ)‐containing plaques as evidenced by amyloid imaging and cerebrospinal fluid (CSF) Aβ1–42 (Aβ42) is an early indicator of preclinical Alzheimer disease (AD). To better understand their relationship during the earliest preclinical stages, we investigated baseline CSF markers in cognitively normal individuals at different stages of amyloid deposition defined by longitudinal amyloid imaging with Pittsburgh compound B (PIB): (1) PIB‐negative at baseline and follow‐up (PIB−; normal), (2) PIB‐negative at baseline but PIB‐positive at follow‐up (PIB converters; early preclinical AD), and (3) PIB‐positive at baseline and follow‐up (PIB+; preclinical AD).MethodsCognitively normal individuals (n = 164) who had undergone baseline PIB scan and CSF collection within 1 year of each other and at least 1 additional PIB follow‐up were included. Amyloid status was defined dichotomously using an a priori mean cortical cutoff.ResultsPIB converters (n = 20) at baseline exhibited significantly lower CSF Aβ42 compared to those who remained PIB‐negative (n = 123), but higher compared to the PIB+ group (n = 21). A robust negative correlation (r = −0.879, p = 0.0001) between CSF Aβ42 and absolute (but subthreshold) PIB binding was observed during this early preclinical stage. The negative correlation was not as strong once individuals were PIB‐positive (r = −0.456, p = 0.038), and there was no correlation in the stable PIB− group (p = 0.905) or in the group (n = 10) with early symptomatic AD (p = 0.537).InterpretationCSF Aβ42 levels are tightly coupled with cortical amyloid load in the earliest stages of preclinical AD, and begin to decrease dramatically prior to the point when an abnormal threshold of cortical accumulation is detected with amyloid imaging. Ann Neurol 2016;80:379–387
A Nanoarchitecture Based on Silver and Copper Oxide with an Exceptional Response in the Chlorine‐Promoted Epoxidation of Ethylene
Authors: Ramirez Adrian , Hueso Jose L. , Suarez Hugo , Mallada Reyes , Ibarra Alfonso , Irusta Silvia , Santamaria Jesus 
Published: July 2016

AbstractThe selective oxidation of ethylene to ethylene epoxide is highly challenging as a result of competing reaction pathways leading to the deep oxidation of both ethylene and ethylene oxide. Herein we present a novel catalyst based on silver and copper oxide with an excellent response in the selective oxidation pathway towards ethylene epoxide. The catalyst is composed of different silver nanostructures dispersed on a tubular copper oxide matrix. This type of hybrid nanoarchitecture seems to facilitate the accommodation of chlorine promoters, leading to high yields at low reaction temperatures. The stability after the addition of chlorine promoters implies a substantial improvement over the industrial practice: a single pretreatment step at ambient pressure suffices in contrast with the common practice of continuously feeding organochlorinated precursors during the reaction.
Biopolymer films to control fusarium dry rot and their application to preserve potato tubers
Authors: Bilbao‐Sainz Cristina , Chiou Bor‐Sen , Valenzuela‐Medina Diana , Imam Syed H. , Vega‐Gálvez Antonio , Orts William J. 
Published: July 2016

ABSTRACTFilms were cast using sodium alginate (NaAlg), high molecular weight (HMW) chitosan, and low molecular weight (LMW) chitosan as film forming biopolymers. Fludioxonil (Fl) at 1% concentration was used as fungicide. Thermal stability, mechanical, and water sorption properties of the films were examined. The effects of films on the Fusarium solani colony radial growth were evaluated in vitro and in potato tubers. Results showed that chitosan films were more thermally stable and less hydrophilic than alginate films. Addition of fluodioxonil to the films significantly reduced the film strength and increased the elongation at break as well as the film stiffness. In vitro studies showed that when fludioxonil was added to the formulation, NaAlg and Chitosan‐LMW films had significantly higher antifungal activity (Fungistatic index = 56%) than Chitosan‐HMW films (Fungistatic index = 50%). In vivo studies showed that Chitosan‐LMW‐1%Fl films delay the mycelial growth of F. solani in tubers kept at 25 °C for 2 weeks. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44017.
A dipeptide‐based superhydrogel: Removal of toxic dyes and heavy metal ions from waste water
Authors: Nandi Nibedita , Baral Abhishek , Basu Kingshuk , Roy Subhasish , Banerjee Arindam 
Published: July 2016

AbstractA short peptide‐based molecule has been found to form a strong hydrogel at phosphate buffer solution of pH 7.46. The hydrogel has been characterized thoroughly using various techniques including field emission scanning electron microscopy (FE‐SEM), wide angle powder X‐ray diffraction (PXRD), and rheological analysis. It has been observed from FE‐SEM images that entangled nanofiber network is responsible for gelation. Rheological investigation demonstrates that the self‐assembly of this synthetic dipeptide results in the formation of mechanically strong hydrogel with storage modulus (G′) around 104 Pa. This gel has been used for removing both cationic and anionic toxic organic dyes (Brilliant Blue, Congo red, Malachite Green, Rhodamine B) and metal ions (Co2+ and Ni2+) from waste water. Moreover, only a small amount of the gelator is required (less than 1 mg/mL) for preparation of this superhydrogel and even this hydrogel can be reused three times for dye/metal ion absorption. This signifies the importance of the hydrogel towards waste water management.
Prediction of survival of diffuse large B‐cell lymphoma patients via the expression of three inflammatory genes
Authors: Zhao Shuangtao , Bai Nan , Cui Jianlin , Xiang Rong , Li Na 
Published: July 2016

AbstractCurrently, several gene‐expression signatures that were used to predict survival of diffuse large B‐cell lymphoma (DLBCL) patients, showed a restriction on the practical work for lack of convenient operation. In this study, we screened inflammatory genes whose expression correlated with survival of DLBCL and established a predictive model including IL6, IL1A and CSF3 through multivariate Cox regression based on the expression of these three genes. We validated the model at protein level in our clinical serum cohort composed of 101 patients of DLBCL and 50 healthy controls and 534 DLBCL patients at mRNA level from three independent Gene Expression Omnibus (GEO) data sets. We found our model to be independent of the International Prognostic Index (IPI), moreover, it can augment the predictive power of IPI. In summary, our three‐gene model is sufficient to predict survival of DLBCL patients via measuring the concentration of three inflammatory cytokines in peripheral blood.
Antiplatelet therapy and outcome in patients undergoing surgery following coronary stenting: Results of the surgery after stenting registry
Authors: Rossini Roberta , Angiolillo Dominick J. , Musumeci Giuseppe , Capodanno Davide , Lettino Maddalena , Trabattoni Daniela , Pilleri Annarita , Calabria Paolo , Colombo Paola , Bernabò Paola , Ferlini Marco , Ferri Marco , Tarantini Giuseppe , De Servi Stefano , Savonitto Stefano 
Published: July 2016

ObjectivesThe aim of the present study was to define the feasibility and clinical impact of complying with national consensus recommendations on perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and noncardiac surgery.BackgroundThere are limited evidence‐based recommendations on the perioperative management of antiplatelet therapy in stented patients undergoing surgery.MethodsThe recommendations provided by the national consensus document were applied in a multicenter, prospective registry of consecutive patients with prior coronary stenting undergoing any type of surgery at 19 hospitals in Italy. The primary end‐point was in‐hospital net adverse clinical events (NACE) represented by the composite of all‐cause death, myocardial infarction, probable/definite stent thrombosis and Bleeding Academic Research Consortium (BARC) grade ≥3 bleeding. Patients were followed for 30 days.ResultsA total of 1,082 patients were enrolled. Adherence to consensus recommendations occurred in 85% of the cases. Perioperative aspirin and dual antiplatelet therapy were maintained in 69.7 and 10.5% of the cases, respectively. In‐hospital NACE rate was 12.7%, being significantly higher in patients undergoing cardiac surgery (36.3% vs. 7.3%, P < 0.01), mainly due to BARC 3 bleeding events (32.3%). At 30 days, MACE rates were similar (3.5% vs. 3.5%, P = NS) in patients undergoing cardiac and noncardiac surgery, whereas BARC ≥3 bleeding events were significantly higher with cardiac surgery (36.3% vs. 5.6%, P < 0.01).ConclusionsThe results of this registry demonstrate the safety and feasibility of applying a national consensus document on the perioperative management of antiplatelet therapy in stented patients undergoing surgery. © 2016 Wiley Periodicals, Inc.
Ablation or surgery for medically refractory HCM. Updating an imperfect dataset
Authors: Bader Yousef , Kimmelstiel Carey 
Published: July 2016

Key Points

Retrospective comparison of alcohol septal ablation with surgical myectomy suggests that although there is a greater reduction in LVOT gradient with surgical myectomy, symptom relief and survival are similar between the two treatment strategies.
In patients who don't have an anatomic indication for surgical myectomy, alcohol septal ablation appears to be a safe and effective alternative.
Patients with medication‐refractory HOCM require a multi‐disciplinary assessment, which is best performed at specialized treatment centers, to assess which therapy is best suited to treat them.
Molybdenum Imido Alkylidene N‐Heterocyclic Carbene Complexes: Structure–Productivity Correlations and Mechanistic Insights
Authors: Buchmeiser Michael R. , Sen Suman , Lienert Christina , Widmann Laura , Schowner Roman , Herz Katharina , Hauser Philipp , Frey Wolfgang , Wang Dongren 
Published: July 2016

AbstractThe syntheses and single‐crystal X‐ray structures of a series of Mo–imido alkylidene N‐heterocyclic carbene (NHC) complexes (1–15) and of the first complexes containing bidentate NHC‐phenolate ligands (16–18) are reported. Mo(N‐2,6‐Me2‐C6H3)((1‐R‐phenethyl)‐3‐mesitylimidazolidin‐2‐ylidene)(CHR)(OTf)2 (R=CMe2Ph, 1) is the first enantiomerically pure Mo–imido alkylidene NHC catalyst. With [Mo(N‐2,6‐Me2‐C6H3)(IMes)(CHR)(CH3CN)(OTf)(CH3CN)+ B(ArF)4−] (7), turnover numbers up to 545 000 were achieved in the homometathesis (HM) of 1‐octene and 1‐nonene (≤95 % E). With 7 and 1‐nonene, a turnover frequency (TOF4 min) of 8860 min−1 was determined. Productivity and E/Z‐selectivity were correlated with catalyst structure. For 1, Mo(N‐3,5‐Me2‐C6H3)(IMesH2)(CHR)(OTf)2 (9) and Mo(N‐3,5‐Me2‐C6H3)(IMes)(CHR)(OTf)2 (10), productivity was correlated with the coalescence temperature of the two triflates, determined by variable‐temperature 19F NMR spectroscopy. The square‐planar conformer is postulated to be the most relevant for the catalyst activation.
Star‐Shaped Conjugated Molecules with Oxa‐ or Thiadiazole Bithiophene Side Arms
Authors: Kotwica Kamil , Kostyuchenko Anastasia S. , Data Przemyslaw , Marszalek Tomasz , Skorka Lukasz , Jaroch Tomasz , Kacka Sylwia , Zagorska Malgorzata , Nowakowski Robert , Monkman Andrew P. , Fisyuk Alexander S. , Pisula Wojciech , Pron Adam 
Published: July 2016

AbstractStar‐shaped conjugated molecules, consisting of a benzene central unit symmetrically trisubstituted with either oxa‐ or thiadiazole bithiophene groups, were synthesized as promising molecules and building blocks for application in (opto)electronics and electrochromic devices. Their optical (Eg(opt)) as well as electrochemical (Eg(electro)) band gaps depended on the type of the side arm and the number of solubilizing alkyl substituents. Oxadiazole derivatives showed Eg(opt) slightly below 3 eV and by 0.2 eV larger than those determined for thiadiazole‐based compounds. The presence of alkyl substituents in the arms additionally lowered the band gap. The obtained compounds were efficient electroluminophores in guest/host‐type light‐emitting diodes. They also showed a strong tendency to self‐organize in monolayers deposited on graphite, as evidenced by scanning tunneling microscopy. The structural studies by X‐ray scattering revealed the formation of supramolecular columnar stacks in which the molecules were organized. Differences in macroscopic alignment in the specimen indicated variations in the self‐assembly mechanism between the molecules. The compounds as trifunctional monomers were electrochemically polymerized to yield the corresponding polymer network. As shown by UV/Vis‐NIR spectroelectrochemical studies, these networks exhibited reversible electrochromic behavior both in the oxidation and in the reduction modes.
A Multifunctional Surface That Simultaneously Balances Hydrophilic Enzyme Catalysis and Hydrophobic Water Repellency
Authors: Lawton Timothy J. , Uzarski Joshua R. , Filocamo Shaun F. 
Published: July 2016

AbstractThe compatibility of multiple functions at a single interface is difficult to achieve, but is even more challenging when the functions directly counteract one another. This study provides insight into the creation of a simultaneously multifunctional surface formed by balancing two orthogonal functions; water repellency and enzyme catalysis. A partially fluorinated thiol is used to impart bulk hydrophobicity on the surface, and an N‐hydroxysuccinimide ester‐terminated thiol provides a specific anchoring sites for the covalent enzyme attachment. Different ratios of the two thiols are mixed together to form amphiphilic self‐assembled monolayers, which are characterized with polarization‐modulation infrared reflection–absorption spectroscopy and contact angle goniometry. The enzyme activity is measured by a fluorescence assay. With the results collected here, specific surface compositions are identified at which the orthogonal functions of water repellency and enzyme catalysis are balanced and exist simultaneously. An understanding of how to effectively balance orthogonal functions at surfaces can be extended to a number of higher‐scale applications.
Uranium–Carbene–Imido Metalla‐Allenes: Ancillary‐Ligand‐Controlled cis‐/trans‐Isomerisation and Assessment of trans Influence in the R2C=UIV=NR′ Unit (R=Ph2PNSiMe3; R′=CPh3)
Authors: Lu Erli , Cooper Oliver J. , Tuna Floriana , Wooles Ashley J. , Kaltsoyannis Nikolas , Liddle Stephen T. 
Published: July 2016

AbstractUranium(IV)–carbene–imido complexes [U(BIPMTMS)(NCPh3)(κ2‐N,N′‐BIPY)] (2; BIPMTMS=C(PPh2NSiMe3)2; BIPY=2,2‐bipyridine) and [U(BIPMTMS)(NCPh3)(DMAP)2] (3; DMAP=4‐dimethylamino‐pyridine) that contain unprecedented, discrete R2C=U=NR′ units are reported. These complexes complete the family of E=U=E (E=CR2, NR, O) metalla‐allenes with feasible first‐row hetero‐element combinations. Intriguingly, 2 and 3 contain cis‐ and trans‐C=U=N units, respectively, representing rare examples of controllable cis/trans isomerisation in f‐block chemistry. This work reveals a clear‐cut example of the trans influence in a mid‐valent uranium system, and thus a strong preference for the cis isomer, which is computed in a co‐ligand‐free truncated model—to isolate the electronic trans influence from steric contributions—to be more stable than the trans isomer by approximately 12 kJ mol−1 with an isomerisation barrier of approximately 14 kJ mol−1.
Conducting Graphene Decorated Li3V2(PO4)3/C for Lithium‐Ion Battery Cathode with Superior Rate Capability and Cycling Stability
Authors: Zhou Pan , He Dawei 
Published: July 2016

AbstractIn this study, core‐shell structured Li3V2(PO4)3/C wrapped in graphene nanosheets has been successfully prepared. The reduction of graphene oxide and the synthesis of Li3V2(PO4)3/C are carried out simultaneously using a chemical route followed by a solid‐state reaction. The effects of conducting graphene are studied by X‐ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectra and electrochemical measurements. The results reveal that the graphene sheets not only form a compact and uniform coating layer throughout the Li3V2(PO4)3/C, but also stretch out and cross‐link into a conducting network around the Li3V2(PO4)3/C particles. Thus, the graphene decorated Li3V2(PO4)3/C electrode exhibits superior high‐rate capability and long‐cycle stability. It delivers a reversible discharge capacity of 178.2 mAh·g−1 after 60 cycles at a current density of 0.1 C, and the rate performances of 176, 169.3, 156.1 and 135.7 mAh·g−1 at 1, 2, 5 and 10 C, respectively. The superior electrochemical properties make the graphene decorated Li3V2(PO4)3/C composite a promising cathode material for high‐performance lithium‐ion battery.
Synergistic Enhancement of Electrocatalytic Activity toward Oxygen Reduction Reaction in Alkaline Electrolytes with Pentabasic (Fe, B, N, S, P)‐Doped Reduced Graphene Oxide
Authors: Chen Wei , Sin Munil , Wei Ping‐Jie , Zhang Qian‐Ling , Liu Jin‐Gang 
Published: July 2016

AbstractAs alternatives to Pt‐based electrocatalysts, the development of nonprecious metal catalysts with high performance in the cathodic oxygen reduction reaction (ORR) is highly desirable for widespread use in fuel cells. Here we report a simple approach for preparing pentabasic (Fe, B, N, S, P)‐doped reduced graphene oxide (rGO) via a two‐step doping method of adding boric acid and ferric chloride to ternary (N, S, P)‐doped rGO (NSPG). Electrochemical investigation of the composites for the ORR revealed that simultaneously doping appropriate amounts of Fe and B into the NSPG produced a synergistic effect that endowed the prepared catalyst with both a positively shifted ORR half‐wave potential and high selectivity for the 4e− reduction of O2. The optimized Fe2B‐NSPG catalyst approached a 4e− process for the ORR with a half‐wave potential (E1/2=0.90 V vs. RHE) even 30 mV higher than that of the commercial Pt/C catalyst in alkaline solution. Furthermore, relative to the Pt/C catalyst, the Fe2B‐NSPG demonstrated superior stability and excellent tolerance of the methanol cross‐over effect. This simple method afforded pentabasic (Fe, B, N, S, P)‐doped rGO as a promising nonprecious metal catalyst used for alkaline fuel cells.
Synthesis of Unsymmetrical 1,3‐Diynes via Pd/Cu‐Catalyzed Cross‐Coupling of Terminal Alkynes at Room Temperature
Authors: Liu Yashuai , Liu Ping , Gu Ningning , Xie Jianwei , Liu Yan , Dai Bin 
Published: July 2016

AbstractA facile and practical synthetic route of unsymmetrical 1,3‐diynes via the PdCl/CuI catalyzed oxidative coupling of two different terminal alkynes has been developed by using 3‐(diphenylphosphino)propanoic acid as a ligand in the presence of oxygen. This system is suitable for not only aromatic alkynes but also heteroaromatic and aliphatic alkynes which were transformed into the corresponding unsymmetrical 1,3‐diynes in moderate to good yields at room temperature. Moreover, the unsymmetrical 1,3‐diynes were also obtained on a multi‐gram scale. Mechanistic studies suggest that oxygen plays a key role in the catalytic cycles.
Photoelectrochemical Behavior of Sn‐Doped α‐Fe2O3 Photoanode with Different Reducer
Authors: Cai Jiajia , Liu Yinglei , Li Song , Gao Meiqi , Qin Gaowu 
Published: July 2016

AbstractHematite has been considered as one of the most promising photoanode candidates for solar water‐splitting. However, its photoelectrochemical (PEC) efficiency is largely constrained by its sluggish oxygen evolution reaction. In this work, the photoelectrochemical performance of hematite was investigated in electrolytes containing different sacrificial agent. The photocurrent densities, onset potential, charge transfer resistance, Helmholtz capacitance at semiconductor liquid junctions (SCLJs), and their correlations were systematically studied. It was found that the onset potential is around the CH peak potential and is related to the photovoltage. The surface states pinning the Fermi levels of the hematite photoanode are related to the adsorbed water molecules regardless of the sacrificial agents in the electrolyte.
Porous CoF2 Spheres Synthesized by a One‐Pot Solvothermal Method as High Capacity Cathode Materials for Lithium‐Ion Batteries
Authors: Guan Qun , Cheng Jianli , Li Xiaodong , Ni Wei , Wang Bin 
Published: July 2016

AbstractUp to now, there are rare reports of CoF2 spheres used as high capacity cathode materials. Herein, porous CoF2 spheres were synthesized and studied as cathode materials for LIBs. The porous CoF2 spheres were synthesized by a facile one‐pot solvothermal method using a safe and inexpensive ammonium fluoride as the fluorine sources. The nature of the synthesis can avoid using corrosive fluorine sources and additional high‐temperature thermal treatment. The structure, morphologies and electrochemical performance of the samples obtained at different reaction times and solvothermal temperatures were investigated. The results show that the CoF2 spheres obtained at 200 °C for 20 h show better electrochemical performances, including a high initial discharge capacity, good capacity retention and high Coulombic efficiency. It can deliver a high initial discharge capacity of 537.8 mA•h•g−1 and keep 127.4 mA•h•g−1 after 30 cycles used as cathode materials for lithium‐ion batteries. The good electrochemical performances may be attributed to good crystallinity, porous structure and relatively intermediate sphere size.
Effect of Hydrogen Binding on Selective Recognition of Halide Anions
Authors: Du Juan , Kang Kang , Hu Jinchuan , Mao Lijun , Yuan Lihua , Feng Wen 
Published: July 2016

AbstractThe interplay of molecular rigidity enforced by interior or exterior hydrogen bonding and affinity for binding halide anions is described to demonstrate the effect of intramolecular hydrogen bonding in anion recognition process. To this end pyridine‐2,6‐dicarboxamides1and2, and aromatic oligoamides3and4containing intramolecular hydrogen bonds were explored for their ability in associating with tetrabutylammonium halide (Cl−, Br−, and I−). Binding constants in chloroform solution were calculated using nonlinear curve‐fitting method based on1H NMR titration experiments. The trimeric amide3, which adopts a crescent conformation as revealed by single‐crystal X‐ray diffraction analysis, strongly binds chloride anion with binding constant as high as 379 L·mol−1. This is more than 6 times greater than the binding constant for the control receptor2with a backbone that is only partially rigidified. The comparative data provided supportive information for rationalizing the observed affinity difference in binding halide anions in terms of local preorganization effected by interior or exterior hydrogen bonding.
One‐Pot Synthesis of Hantzsch Pyridines via NH4I Promoted Condensation of 1,3‐Dicarbonyl Compounds with DMSO and NH4OAc
Authors: Chang Liming , Lai Junyi , Yuan Gaoqing 
Published: July 2016

AbstractA one‐pot synthesis of Hantzsch pyridines was achieved through NH4I‐promoted condensation of 1,3‐dicarbonyl compounds with DMSO and NH4OAc, in which the C4 of the pyridine rings was derived from DMSO and the nitrogen atom resulted from NH4OAc and NH4I. The target product could be obtained in moderate to excellent yields.