bluuebunny/crossref_metadata_2025_split huggingface dataset:
Philosophical Concept of Time and Space in Spectral Music of the Twentieth Century of Gérard Grisey
Authors: Zhadik Iryna 
Published: September 2024

The purpose of the article is to reveal the main G. Grisey’s concepts regarding spectral composition in the 20th century. The research methodology consists in the use of methods of analysis and synthesis of the works by G. Grisey on the spectral method in the music of the 20th century. Source science and system approaches were used to study interrelated elements in the characteristics of the spectral method in the works by G. Grisey. The scientific novelty of the work consists in the generalisation of the results of studying the spectral method in author's music with the effects of specific sound spectra: attack and decay of sound; beats as prototypes of the rhythmic component; filtering and phase distortion as prototypes of the melodic component; intensity when adjusting the volume. It is noted that the results of the synthesis become the sound of an artificially produced musical space with different conditions for the existence of a natural sound structure in it. In such music, the concepts of time and space are inseparable. Time organises events in acoustic space. The space-time paradigm is multidimensional. It is based on the principle of organisational unity from the level of micro to macro space. Conclusions. The conceptual approaches of space-time in the works of the composer of the French spectral school G. Grisey are analysed. The composer noted that the appeal to the liminal – threshold concept of time and space of spectralism is based on natural and physiological processes. In the treatise of G. Grisey "Tempus ex machina" and his composition of the same name, the philosophical significance of the coordinate axis of the system is substantiated. For this, it was necessary to draw a parallel with Moll's theory of information, the natural-scientific law of Weber-Fechner. The technologies of mastering the intra-sound space in spectralism lead to a new sound concept – sound as a phenomenon of life. Switching plans from the internal composition of sound to external factors, the transition from microphonic to macrophonic space allows us to assert that sound is capable of life and death, when the starting point of understanding time in music is its relativisation as a rejection of absolute meaning. This is actually the conceptual basis in the work of G. Grisey, as one of the concepts of musical time in the compositions of the second half of the 20th century. They are characterised by a high degree of subjectivity of temporary sensations.
To the issues of sources study on the musical interpretation of Ukrainian classics poetry in the works of pop performers
Authors: Padalko Viktoriia 
Published: September 2024

The purpose of the article is to analyse scientific research and publications on the musical interpretation of Ukrainian classical poetry in the works of pop artists. The research methodology. Analytical and retrospective methods, as well as the method of comparative analysis, were used to structure the theoretical and methodological base. Since the topic of research covers issues of both musicology and literature, an interdisciplinary approach was used. The scientific novelty of the work lies in the definition of interpretation as a phenomenon that contributes to the organic synthesis of musical and verbal art, gives a direct impact on the musical interpretation of poetic texts by classics, the creativity of academic and pop composers and performers. Conclusions. The article noted the actual increase in the number of musical interpretations of poetic texts by Ukrainian classics. The consideration of scientific works that constitute the theoretical basis for the comprehensive study of the relevant songs and compositions, was carried out. Research directions are divided into the study of: general features of interpretation as a phenomenon (O. Afonina, O. Benziuk, P. Ivanyshyn, O. Kolesnyk, S. Sadovenko); problems of music and literature synthesis (O. Frait, I. Ivanova, A. Mizitova, I. Vezhnevets, O. Zinkevych); musical interpretation (O. Domashchenko, M. Heichenko, V. Ivanova, O. Katrych, V. Kulikova, V. Moskalenko, O. Oleksiuk, V. Panasiuk, V. Soloviov); interpretation of texts, their semantics, in particular, through the prism of inner musicality (M. Naienko, Z. Pakholok, I. Shchukina, G. Siuta); works of academic and pop composers and performers-interpreters of the poetry of the classics (H. Filatova, O. Frait, H. Karas, N. Koroliuk, V. Stepurko, I. Shturmak). Musical Shevchenkiana is relatively covered in the scientific discourse, but, for the most part, only in the realm of academic music (the same name publication from the funds of the National V. I. Vernadskyi Library of Ukraine, 2020; the book “Musical Shevchenkiana” by M. Hulkovskyi, 2023). Except for few articles, the source base on the works of pop artists in the context of the interpretation of poetry by the classics only consists of the interviews, publications from the websites, blogs, and pages of social networks of the performers.
R. Schuman's Piano Concerto Or. 92 and 134 in the Context of Biedermeier's Style Principles
Authors: Xuang Juntao 
Published: September 2024

The purpose of this study is to analyse two "small" Concertos by R. Schumann, the laconic two-parts of which in the form of Introduction and Allegro Appassionato op. 92, Introductions and Allegro op. 134 puts them in a direct relationship with the aesthetics of miniaturism of Biedermeier's instruction, according to which the height of ethical and artistic expression is in a proportional relationship with the brevity of the sound space. The methodological basis of the study is the intonation approach of the school of B. Asafyev in Ukraine, embodied in the works of D. Androsova, O. Markova, O. Muravska, and L. Shevchenko, which has direct implications for the institutions of Chinese musicology (see the works of Ma Wei). The specifics of the historical-descriptive, musicological analytical, cultural, stylistic comparative, intellectual-biographical (according to the works of V. Shulhina, O. Yakovlev), interdisciplinary approach make up the specifics of the research apparatus of the author of the essay. The scientific novelty of the work is revealed in the fact that, for the first time in Ukrainian and Chinese musicology, the so-called "small" Concertos of R. Schuman op. 92 and 134 in the light of the positions of Biedermeier's "diamond" pianism of "easy playing" in the continuation of Mozartianism in piano works (based on the works of D. Androsova and L. Shevchenko) and in the development of the concept of neo-symbolism of post-avant-garde modernity according to O. Markova in relation to the performing revival of that kind of stylistic heritage. Conclusions. Piano concertos by R. Schuman op. 92 and 134 are marked by the advantages of pianistic lyrical monologue over the detection of theatrical and dramatic "breakthroughs". The predominance of the lyricism of the piano monologue nourishes the positions of romanticism against the background of Biedermeier's ideal expressive instructions, inspired by religious harmony, addressed to the ideals of "song without words" of Mendelssohn's system, aimed at a harmonious worldview. We insist on the concept of piano Concertos regarding the compositions of the specified opus, the specifics of which ("Concert-piece" for piano with orchestra op. 92, "Concert Allegro with Introduction" op. 134) corresponds to the parallel to obligatory baroque concerts with signs of the so-called "concert form", an equation that was significantly corrected by the lyrical-monologised concert performance of the Romantic era.
F. Chopin's sonatas in the context of Biedermeier's guidelines for their author's performance work
Authors: Zhu Ziyi 
Published: September 2024

The purpose of this work is to extract the Biedermeier features of F. Chopin in his "biggest" works – the Sonatas, of which the First is a fully Chopinian "Warsaw Biedermeier", in which not a small number of forms, but certain semantic turns in the expression indicate belonging to the named direction, and the latter note the features of Chopin's famous Second and Third sonatas. The methodological basis of the study is the intonation approach of accepting the genetic unity of musical and speech principles in the development of the concepts of B. Asafiev and B. Yavorskyi in the works of D. Androsova, O. Markova, I. Podobas, L. Stepanova, L. Shevchenko, with an emphasis on the hermeneutic perspective of such an approach. The methods are also highlighted – biographical-descriptive, with an emphasis on its intellectual-biographical aspect, analytical-structural as focused on the musicological specificity of the presentation of compositions, interspecies stylistic comparative. The scientific novelty of the work covers the characteristics of expression in Chopin's Sonatas, which come from the essence of Biedermeier's worldview, including the emphasis on the direct citation of other authors' text, noted by O. Kozarenko, which corresponds to the spiritual practice of relying on canonical instructions and distancing oneself from egocentrically asserted authorship. This is most clearly shown in the First Sonata, but also takes place in the Second and Third, which, according to D. Kaempfer, form a certain cycle connected with the First Sonata by Bachianism. Conclusions. Biedermeier's approach manifests itself, both in small and large forms, in the form of emphasised direct quoting from other authors' texts, which are marked by the canonicity of aesthetic and ethical meaning and combined with spiritual texts due to the avoidance of the theatrical procedurality of the composition. Each of Chopin's Sonatas, despite a direct quote from the Invention of I. S. Bach in the First, contains "Bahianisms" as a thematic and compositional embodiment in order to demonstrate loyalty to the adopted high ideal. Each of the finales of the Sonata (especially clearly – in the Second one) presents something figuratively and semantically independent in relation to the previous parts, building a "cadenceless" ending as a "step into Infinity".
A New Highly Effective Development and Validation of Trastuzumab and Hyaluronidase-Oysk in Bulk and Pharmaceutical Dosage form by Using RP-HPLC Method
Authors: Babu Sruthi , Sumalatha J. , Salomi P. , Kumar S. Nelson 
Published: September 2024

A simple, rapid, precise, sensitive, and reproducible Reverse phase High-performance liquid chromatography (RP-HPLC) method has been developed for the quantitative analysis of Trastuzumab and Hyaluronidase-OYSK in the pharmaceutical dosage form. Chromatographic separation of Trastuzumab and Hyaluronidase-OYSK was achieved on Waters Alliance-e2695by using Agilent Eclipse XDB (250x 4.6mm, 5µ) column and the mobile phase containing Acetonitrile: Ammonium formate pH-3.0/OPA in the ratio of 30:70% v/v. The flow rate was 1.0 ml/min; detection was carried out by absorption at 228nm using a photodiode array detector at ambient temperature. The number of theoretical plates and tailing factor for Trastuzumab and Hyaluronidase-OYSK were NLT 2000 and should not be more than 2 respectively. % Relative standard deviation of peak areas of all measurements always less than 2.0. The proposed method was validated according to ICH guidelines. The method was found to be simple, economical, suitable, precise, accurate & robust method for quantitative analysis of Trastuzumab and Hyaluronidase-OYSK study of its stability.
Peran Program Keterampilan Bagi Remaja Tunarungu dalam Penentuan Karier
Authors: Selviani Mega 
Published: September 2024

Abstract
Kehilangan pendengaran dapat menimbulkan hambatan dalam komunikasi dan interaksi sosial, yang berakibat pada kesulitan dalam pendidikan, karir, dan kehidupan sehari-hari. Hal ini membuat remaja tunarungu perlu memiliki keterampilan khusus untuk mengatasi hambatan tersebut dan mencapai kesuksesan.. Tujuan penelitian ini, menganalisis program keterampilan di SLB Negeri Kotagajah dan bagaimana program tersebut membantu siswa tunarungu dalam menentukan karir. Metode penelitian ini menggunakan kualitatif deskriptif. Data diambil melalui observasi, wawancara dan dokumentasi serta dilakukan validasi dengan teknik analisis data. Selanjutnya data dianalisis dengan cara reduksi data, penyajian data, dan kesimpulan. Hasil penelitian menunjukkan bahwa, SLB Negeri Kotagajah membekali siswanya dengan 8 program keterampilan (soft skill) untuk masa depan mereka. Program ini membantu siswa tunarungu dalam menentukan karir, membantu mereka mengidentifikasi minat dan bakat mereka, mengembangkan keterampilan yang dibutuhkan untuk mencapai karir yang diinginkan. Kesimpulannya, program keterampilan di SLB Negeri Kotagajah merupakan salah satu strategi bimbingan dan konseling yang efektif dalam membantu remaja tunarungu menentukan karir mereka.
Keywords : Remaja tunatungu, Penentuan karier, Program Keterampilan
Abstract
Hearing loss can create obstacles in communication and social interaction, resulting in difficulties in education, career and daily life. This makes deaf teenagers need to have special skills to overcome these obstacles and achieve success.. The aim of this research is to analyze the skills program at the Kotagajah State Special School and how the program helps deaf students in determining careers. This research method uses descriptive qualitative. Data was taken through observation, interviews and documentation and validated using data analysis techniques. Next, the data was analyzed by means of data reduction, data presentation, and conclusions. The research results show that Kotagajah State SLB equips its students with 8 soft skills programs for their future.This program assists deaf students in determining careers, helps them identify their interests and talents, develops the skills needed to achieve the desired career. In conclusion,The skills program at the Kotagajah State Special School is one of the effective guidance and counseling strategies in helping deaf teenagers determine their careers.
Keywords: Deaf teenagers, career determination, skills program
Evaluating the Relationship Between Somatic Dysfunction, Physical Activity Level, and Perceived Stress Level: A Pilot Study
Authors: Bergman Stephen , Langford Tyler , Marik Cody , Whitefoot Cody 
Published: September 2024

Abstract

Introduction:
Somatic dysfunction (SD) is the basis for osteopathic manipulative treatment (OMT). SD is found through palpatory physical assessment and represents a degree of strain on the homeostatic system of the body. This study investigates the relationship between SD and physical activity (PA) level as well as perceived stress level (POMS).

Methods:
This observational cohort study collected Somatic Dysfunction Scale (SDS) scores together with a score from a perceived stress questionnaire, the Profile of Mood States (POMS), and an activity level assessed with via a physical activity (PA) questionnaire. Data was collected on three separate days, approximately 6 weeks apart. Questionnaires were administered and collected initially, then SDS scores were assessed independently by two examiners that were blinded from each other and from the questionnaire data.

Results:
There was no significant relationship between SD and POMS or PA. There was a possible significant inverse relationship between the TMD from the POMS and a moderate level of PA with a negative Spearman rank correlation (-.194) and p = 0.089. There was a statistically significant correlation between examiners’ SDS scores.

Conclusion:
Stand-alone SDS values may not be a useful measure to correlate with stress levels and activity levels. However, SDS values may be used to assess the longitudinal response to interventions such as OMT.
Activity of Fluoroquinolones and Proton Pump Inhibitors against Resistant Oral Bacterial Biofilms, in silico and in vitro Analysis
Authors: Kamran Muhammad , Raza Muhammad , Ullah Riaz , Alotaibi Amal , Bano Ràheela , Zaman Ali , Chaman Sadia , Iqbal Kashif , Rasool Shahid , Amin Adnan 
Published: September 2024

Abstract
Oral bacterial infections are a great health concern worldwide especially in diabetic patients. Emergence of antimicrobial resistance with reference to biofilms in oral cavity is of great concern. We investigated antibiotics combination with proton pump inhibitors against oral clinical isolates. The strains were identified as Staphylococcus epidermidis and Staphylococcus aureus by the 16S rRNA gene sequencing. In molecular docking, ciprofloxacin, levofloxacin, and omeprazole best fit to active pockets of transcriptional regulators 4BXI and 3QP1. None of the proton pump inhibitors were active against S. epidermidis, whereas omeprazole showed significant inhibition (MIC 3.9 μg/ml). Fluoroquinolones were active against both S. epidermidis and S. aureus. In combination analysis, a marked decrease in minimum inhibitory concentration was noticed with omeprazole (MIC 0.12 μg/ml). In antiquorum sensing experiments, a significant inhibitory zone was shown for all fluoroquinolones (14–20 mm), whereas among proton pump inhibitors, only omeprazole (12 ± 0.12 mm) was active against Chromobacterium violaceum. In combination analysis, a moderate increase in antiquorum sensing activity was recorded for ciprofloxacin, ofloxacin, and proton pump inhibitors. Further, significant S. aureus biofilm eradication was recorded using of ciprofloxacin, levofloxacin, and omeprazole combination (78 ± 2.1%). The time-kill kinetic studies indicated a bactericidal effect by ciprofloxacin: levofloxacin: omeprazole combination over 24 hrs. It was concluded that fluoroquinolone combined with omeprazole could be an effective treatment option for eradicating oral bacterial biofilms.
Pheno- and Genotypic Epidemiological Characterization of Vancomycin-Resistant Enterococcus faecium Isolates from Intensive Care Unit Patients in Central Türkiye
Authors: Akineden Altan , ÇiÇek Cemal , TÜrkel SelÇuk , Khan Izhar U.H. , Abdulmawjood Amir 
Published: September 2024

Abstract
Vancomycin-resistant Enterococcus faecium (VRE) has been detected in Türkiye. Only limited information is available on its dissemination in the central regions of the country. This study describes the first epidemiological characterization of VRE clinical isolates detected in patients in a hospital in the province of Aksaray. In this one-year study conducted between 2021 and 2022, stool samples from intensive care unit patients were screened for VRE using the phenotypic E-test method, and the antibiotic sensitivity test was analyzed by using the VITEK® 2 system. A molecular assay for confirmation of species level was carried out by 16S rRNA gene-based sequencing and testing for antibiotic resistance (vanA or vanB) and virulence factor-encoding genes (esp, asa1, and hyl). Further, genotypic characterization was determined by macro-restriction fragment pattern analysis (MRFPA) of genomic DNA digested with SmaI restriction enzyme. Of the total 350 Enterococcus positive patients from different hospital intensive care units, 22 (6.3%) were positive for VRE using the phenotypic E-test method. All isolates showed resistance to ampicillin, ciprofloxacin, vancomycin, and teicoplanin and positive amplification for the vanA gene. However, none of the isolates was positive for the vanB gene. The most prevalent virulence gene was esp. The results indicate that the isolates are persistent in the hospital environment and subsequently transmitted to hospitalized patients, thus representing challenges to an outbreak and infection control. These study results would also help formulate more effective strategies to reduce the transmission and propagation of VRE contamination in various hospital settings.
The Effect of Mask Use on Seasonal Virus Diversity in SARS CoV-2 Negative Patients Treated as Inpatients During the 2021–2022 and 2022–2023 Seasonal Flu Period
Authors: Gegin Savaş , Özdemir Burcu , Özdemir Levent , Aksu Esra Arslan , Pazarli Ahmet Cemal , Yazicioğlu Bahadir 
Published: September 2024

Abstract
The study aimed to explore the protective effect of mask use against respiratory tract viral agents during the pandemic. The study included patients with a COVID-19 negative test who were hospitalized in the pulmonary disease clinic with the diagnoses of asthma attack, chronic obstructive pulmonary disease (COPD) exacerbation, and pneumonia in two periods: during mandatory mask use (October 2021 – May 2022) and after the mask mandate was lifted (October 2022 – May 2023). Combined nose and throat swab samples taken from the patients were evaluated for viral agents by using the PCR test method. Viral agents isolated from the patients in the two periods were compared based on hospitalization diagnoses and periods. The study enrolled 1,335 patients, 483 female and 852 male. It was found that viral agents significantly increased during the period without a mask mandate compared to the period when the mask mandate was in effect (41.6% vs. 23.4%) (p < 0.001). During the period without mask mandate, influenza A, H1N1, and RSV/AB viruses significantly increased (p = 0.019, p = 0.003, p < 0.001, respectively). Our results indicated that mask use during the pandemic is protective against the transmission of respiratory tract viruses. Thus, it can be concluded that mask use is important not only in the coronavirus pandemic but also especially in influenza and RSV epidemics.
Avances en identificación genética y análisis de perfiles de ADN en biología forense
Authors: De la Torre Núñez Eliana del Consuelo , Ustariz Fajardo Francisco Javier 
Published: September 2024

Introducción: En la última década, la criminalística ha experimentado un notorio fortalecimiento, extendiéndose más allá de la medicina legal hacia disciplinas como la bioquímica forense y la biología molecular, reflejando la importancia creciente de estas ciencias en el ámbito legal. Objetivo: Recopilar información sobre los avances recientes en la identificación genética y el análisis de perfiles de ADN en el campo de la biología forense, con el fin de comprender su aplicación práctica y su impacto en la resolución de casos judiciales. Metodología: La investigación es documental con alcance exploratorio y descriptivo, abarca una amplia gama de fuentes, incluyendo artículos científicos, libros, y documentos técnicos relacionados con los avances en la identificación genética y el análisis de perfiles de ADN en el campo de la biología forense. Resultados: La investigación permitió la identificación de importantes avances en genética y análisis de perfiles de ADN en biología forense con aplicación práctica y efectiva en el campo forense. Conclusión: El estudio, ha permitido explorar y analizar una amplia gama de temas que abarcan la estructura del ADN, las técnicas de análisis de perfiles genéticos; así como, también la obtención y preservación de muestras biológicas, las consideraciones éticas y legales asociadas a la biología forense. Área de estudio general: Criminalística y Ciencias Forenses. Área de estudio específica: Biología. Tipo de estudio: Artículo de revisión bibliográfica.