bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fungibility, accessibility and clinical utility of remote electronic fetal monitoring in improving maternal emotional status compared with traditional method: A multicenter prospective cohort analysis
Authors: Pan Yu , Chen Zi , Chen Lujiao , Ning Lingli , Wan Huimin , Chen Ting , Zhang Haihong , Jiang Ying , Luo Qiong 
Published: September 2024

AbstractObjectiveSupported by remote signal processing techniques and wireless communication technology, remote electronic fetal monitoring (REFM) has emerged as a promising alternative to traditional electronic fetal monitoring (TEFM) in clinical practice. The aim of this study was to evaluate the comparability, accessibility, and clinical utility of REFM in contrast to TEFM.MethodsThis was a multicenter prospective cohort study. A cohort of 2900 pregnant women were enrolled from three medical centers between June 1, 2021 and June 31, 2022. Among them, 800 utilized REFM, with 760 of them completing the self‐rating anxiety scale (SAS) and self‐rating depression scale (SDS) assessments using the devices for 1 month. The control group comprised 2100 pregnant women who did not use REFM. Additionally, 80 pregnant women concurrently employed both REFM and TEFM, and their respective curve coincidence rates were determined through curve fitting. Primary outcomes encompassed pregnancy outcomes in both groups, average curve coincidence rates between REFM and TEFM, as well as SDS and SAS scores.ResultsAmong the 760 pregnant women who completed SAS and SDS assessments, their average SAS scores before and after 1 month of REFM usage were 43.09 ± 8.04 and 41.58 ± 6.59, respectively. Concurrently, the average SDS scores before and after 1 month of REFM usage were 45.45 ± 9.60 and 44.80 ± 9.17, respectively. A statistically significant decrease was observed in SAS scores (P = 0.005), whereas no significant difference was noted in SDS scores (P = 0.340). Furthermore, a statistically significant difference in the rate of adverse pregnancy outcomes (neonatal asphyxia) emerged between the two groups, those who employed REFM and those who did not (P = 0.021). In the subset of 80 pregnant women employing both REFM and TEFM, all 80 results showed precise congruence between the two methods. The average coincidence rate was determined to be 79.45% ± 12.64%.ConclusionREFM contributes to improved pregnancy outcomes and exhibits a high level of concordance with TEFM, thereby accurately reflecting the quality of fetal heart monitoring. Additionally, REFM effectively mitigates pregnant women's anxiety. Thus, REFM demonstrates comparability, accessibility, and clinical utility.
The role of ubiquitination in health and disease
Authors: Liao Yan , Zhang Wangzheqi , Liu Yang , Zhu Chenglong , Zou Zui 
Published: September 2024

AbstractUbiquitination is an enzymatic process characterized by the covalent attachment of ubiquitin to target proteins, thereby modulating their degradation, transportation, and signal transduction. By precisely regulating protein quality and quantity, ubiquitination is essential for maintaining protein homeostasis, DNA repair, cell cycle regulation, and immune responses. Nevertheless, the diversity of ubiquitin enzymes and their extensive involvement in numerous biological processes contribute to the complexity and variety of diseases resulting from their dysregulation. The ubiquitination process relies on a sophisticated enzymatic system, ubiquitin domains, and ubiquitin receptors, which collectively impart versatility to the ubiquitination pathway. The widespread presence of ubiquitin highlights its potential to induce pathological conditions. Ubiquitinated proteins are predominantly degraded through the proteasomal system, which also plays a key role in regulating protein localization and transport, as well as involvement in inflammatory pathways. This review systematically delineates the roles of ubiquitination in maintaining protein homeostasis, DNA repair, genomic stability, cell cycle regulation, cellular proliferation, and immune and inflammatory responses. Furthermore, the mechanisms by which ubiquitination is implicated in various pathologies, alongside current modulators of ubiquitination are discussed. Enhancing our comprehension of ubiquitination aims to provide novel insights into diseases involving ubiquitination and to propose innovative therapeutic strategies for clinical conditions.
Underutilization of Injectable Parkinson's Disease Medication: An Analysis of Neurologist and Patient Perspectives
Authors: Solis Gianni , Patierno Jordan , Rossol Josh , Kumar Rajeev 
Published: September 2024

ABSTRACTBackgroundWe hypothesized that many neurologists underestimate patients’ willingness to self‐administer injectable Parkinson's disease (PD) medication.ObjectiveTo evaluate patient and physician perceptions contributing to underutilization of PD medications for acute OFF episodes.Analytic MethodData were collected using an online survey including n = 4063 PD patients experiencing OFF episodes and n = 200 neurologists.Results89% of patients were willing to self‐inject rescue therapies to treat acute OFF episodes. After reviewing patient survey data, 54% of general neurologists and 37% of movement disorder specialist (MDS) demonstrated a change in perceptions about patients’ willingness to use self‐injected therapies (P < 0.05). 37% of general neurologists and 21% of MDS indicated a greater likelihood of prescribing these treatments (P < 0.05).ConclusionsMost patients suffering from OFF episodes would be willing to self‐inject to abort their symptoms. Neurologists underestimate this patient acceptance. Understanding patient attitudes and further education about rescue therapies is likely to increase use of these therapies.
Aggrescan4D: A comprehensive tool for pH‐dependent analysis and engineering of protein aggregation propensity
Authors: Zalewski Mateusz , Iglesias Valentin , Bárcenas Oriol , Ventura Salvador , Kmiecik Sebastian 
Published: September 2024

AbstractAggrescan4D (A4D) is an advanced computational tool designed for predicting protein aggregation, leveraging structural information and the influence of pH. Building upon its predecessor, Aggrescan3D (A3D), A4D has undergone numerous enhancements aimed at assisting the improvement of protein solubility. This manuscript reviews A4D's updated functionalities and explains the fundamental principles behind its pH‐dependent calculations. Additionally, it presents an antibody case study to evaluate its performance in comparison with other structure‐based predictors. Notably, A4D integrates advanced protein engineering protocols with pH‐dependent calculations, enhancing its utility in advising solubility‐enhancing mutations. A4D considers the impact of structural flexibility on aggregation propensities, and includes a large set of precalculated predictions. These capabilities should help to open new avenues for both understanding and managing protein aggregation. A4D is accessible through a dedicated web server at https://biocomp.chem.uw.edu.pl/a4d/.
Honey Phytochemicals: Bioactive Agents With Therapeutic Potential for Dermatological Disorders
Authors: McLoone Pauline , Oladejo Toheeb Olalekan , Kassym Laura , McDougall Gordon J. 
Published: September 2024

ABSTRACTHoney has been reported to have a range of biological activities including antimicrobial, immunomodulatory, and wound healing effects. Indeed, medical‐grade honey is currently used in hospitals for the clinical management of wound infections. Honey is also of scientific interest for its therapeutic effects on other dermatological disorders such as atopic dermatitis, rosacea, and skin cancer. Recent studies have uncovered that honey contains a range of phytochemicals including flavonoids, dicarboxylic acids, coumarins, and phenolic acids. In this review, PubMed was used to search the scientific literature on the biological properties of honey phytochemicals in relation to dermatological disorders and to evaluate their potential as bioactive agents, drugs, or cosmeceuticals for the treatment of skin disease. The review revealed that phytochemicals found in honey have antimicrobial, anti‐inflammatory, antiaging, antioxidant, anticancer, depigmenting, photoprotective, wound healing, and skin barrier enhancing properties. Although further high‐quality studies are required to establish clinical efficacy, these findings suggest that honey phytochemicals may have the potential to be used as bioactive agents for the management of a range of dermatological disorders including wounds, psoriasis, atopic dermatitis, vitiligo, rosacea, and skin cancer.
S@FeS2 Core–Shell Cathode Nanomaterial for Preventing Polysulfides Shuttling and Forming Solid Electrolyte Interphase in High‐Rate Li–S Batteries
Authors: Kang Dong Guk , Azimov Farkhod , Seo Dahye , Park Garyeong , Oh Min‐Geun , Lee Hyeon Gyu , Lee Young Joo , Jung Hyun Min , Song Seung‐Wan 
Published: September 2024

AbstractLithium–sulfur (Li–S) battery is a potential next‐generation energy storage technology over lithium‐ion batteries for high capacity, cost‐effective, and environmentally friendly solutions. However, several issues including polysulfides shuttle, low conductivity and limited rate‐capability have hampered its practical application. Herein, a new class of cathode active material with perfect core–shell structure is reported, in which sulfur is fully encapsulated by conductivity‐enhancing FeS2 (named as S@FeS2), for high‐rate application. Surface‐stabilized S@FeS2 cathode exhibits a stable cycling performance under 2 – 20 times higher rates (1–2 C, charged in 30–60 min) than standard rates (e.g., 0.1–0.5 C, charged in 2–10 h), without polysulfides shuttle event. Surface analysis results reveal the unprecedented formation of a stable solid electrolyte interphase (SEI) layer on S@FeS2 cathode, which is distinguished from other sulfur‐based cathodes that are not able to form the SEI layer. The data suggest that the prevention of polysulfides shuttling is owing to the surface protection effect of FeS2 shell and the SEI layer formation overlying core–shell S@FeS2. This unique and potential material concept proposed in the present study will give insight into designing a prospective fast charging Li–S battery.
Biology‐Based Synthesis of Nickel Single Atoms on the Surface of Geobacter sulfurreducens as an Efficient Electrocatalyst for Alkaline Water Electrolysis
Authors: Jimenez‐Sandoval Rodrigo , Katuri Krishna P. , Annadata Harshini V. , Nayak Chandrani , Wehbe Nimer , Melinte Georgian , Saikaly Pascal E. 
Published: September 2024

AbstractSingle‐atom metal catalysts are promising electrocatalysts for water electrolysis. Nickel‐based electrocatalysts have shown attractive application prospects for water electrolysis. However, synthesizing stable Ni single atoms using chemical and physical approaches remains a practical challenge. Here, a facile and precise method for synthesizing stable nickel single atoms on the surface of Geobacter sulfurreducens using a microbial‐mediated extracellular electron transfer (EET) process is demonstrated. It is shown that G. sulfurreducens can effectively anchor nickel single atoms on their surface. X‐ray absorption near‐edge structure and Fourier‐transformed extended X‐ray absorption fine structure spectroscopy confirm that the nickel single atom is coordinated to nitrogen in the cytochromes. The as‐synthesized nickel single atoms on G. sulfurreducens exhibit excellent bifunctional catalytic properties for alkaline water electrolysis with low overpotential (η) to achieve current density (10 mA cm−2) for both hydrogen evolution reactions (η = 80 mV) and oxygen evolution reaction (η = 330 mV) with minimal catalyst loading of 0.0015 mg Ni cm−2. The nickel single‐atom catalyst shows long‐term stability at a constant electrode potential. This synthesis method based on the EET capability of electroactive bacteria provides a simple and scalable approach for producing low‐cost and highly efficient nonnoble transition metal single‐atom catalysts for practical applications.
Software Reliability Prediction by Adaptive Gated Recurrent Unit‐Based Encoder‐Decoder Model With Ensemble Empirical Mode Decomposition
Authors: Yang Minghao , Yang Shunkun , Bian Chong 
Published: September 2024

ABSTRACTAccurate software reliability prediction is significant to software quality assurance. However, the rapid development and evolution of modern software pose more challenges for accurate software quality assessment. With the rapid development of machine learning and intelligent algorithms, data‐driven nonparametric models have gradually attracted increasing attention with outstanding prediction performance. However, we found that there may exist some prediction lags caused by the autocorrelation and nonstationarity of software fault data in the prediction of nonparametric models affecting their performance. To address this problem, we proposed an adaptive gated recurrent unit‐based encoder‐decoder model (ED‐GRU) with ensemble empirical mode decomposition (EEMD), effectively reducing prediction lags and performing accurate software fault number prediction. The autocorrelation and nonstationarity of fault data are first reduced by using first‐order difference and EEMD to clearly characterize the changing trend of the data. The frequency‐specific ED‐GRU networks are then combined to adaptively learn the nonlinear fluctuation trend of fault data under different frequency scales and obtain accurate prediction final results after aggregation. Experiments on eight public datasets showed that the proposed EEMD‐ED‐GRU‐PF model could effectively reduce the prediction lags and achieve the best prediction performance compared with four nonparametric and five parametric baseline methods in all datasets. Therefore, the proposed method can effectively and stably reduce the prediction lag to significantly improve the prediction accuracy. In this way, developers can accurately evaluate the current quality of the software and provide valuable guidance for software development and maintenance.
Dustings of Paradata as Pedagogical Support at Four Archaeological Field-School Sites
Authors: Buchanan Sarah A. , Huntsman Theresa 
Published: September 2024

AbstractArchaeological fieldwork requires systematic approaches to recording and archiving a variety of data, from information about contexts and artifacts to methodologies that can vary from season to season. Drawing together retrospective analyses of data-making efforts in four student-engaged archaeological projects—the Archaeological Exploration of Sardis, American Excavations at Morgantina: Contrada Agnese Project, Poggio Civitate Archaeological Project, and Venus Pompeiana Project—this chapter focuses on the paradata work practiced by on-site data archivists. Paradata are the human processes that generate data. Field schools and the archaeological research they produce benefit from a “dusting,” i.e., analytical narration of the processes, proactively led by data archivists in context and collaboration with team members. Paradata make explicit the pedagogical goals at the heart of each project while simultaneously supporting the contextual integrity of future archaeological research.
The Development of the Uses of the Word dengan from Indonesian Newspaper Period 1910–2010
Authors: Sanarta Gita Ayodhiya , Rovita Dien 
Published: September 2024

AbstractAs a word, dengan will always develop as long as it is used by its speakers. The aim of this study is to explain the development of the uses of the word dengan in bahasa Indonesia based on its function as a conjunction or a preposition in a clause from the year 1910 to 2010. The data sources used in this chapter are Indonesian newspapers from the year 1910 to 2010. The methodology used in this chapter is mixed research of quantitative and qualitative approaches. The quantitative approach is used to see the frequency of the uses of dengan. On the other hand, the qualitative approach is used to classify the word dengan into conjunction or preposition; to determine the meaning of the preposition dengan, and to determine the collocation between the verb and the preposition dengan. As a result, (1) dengan as conjunction could function as a subordinate and coordinative conjunction, (2) dengan as a preposition has eleven meanings, (3) the use of the word dengan between 1910 and 2010 as conjunction has been decreasing while the use as a preposition has been increasing, (4) dengan as a preposition could only collocate with certain verbs.
Analysis of the Indonesian Cultural Elements in Secondary School English Textbooks Published by KEMENDIKBUD
Authors: Perangin-angin Alemina Br. , Sumbayak Desri Maria , Desma Lara , Patimah Siti , Tamala Indah Putri 
Published: September 2024

AbstractCulture is a vital aspect of human development, and education should incorporate local cultural content in textbooks, such as secondary school English textbooks. Teachers play a crucial role in character-building learning and should incorporate multicultural education and value education in history learning. This study aims to identify cultural elements in English textbooks from the KEMENDIKBUD (Ministry of Education, Culture, Research and Technology) for secondary school 7–9th grade. The research uses a descriptive qualitative method, focusing on text and images containing cultural elements. The analysis reveals four elements of local culture in the textbook: the existence of social organizations in nuclear families and communities, a system of living equipment and technology in images of daggers, food, clothing, and bags, art in the form of angklung as a musical tool and “Tangkuban Perahu” narrative as a folklore, and a religious system in images using Muslim culture. These components suggest that the KEMENDIKBUD English textbooks for secondary school students reflect aspects of Indonesian culture.
End of the world brane networks for infinite distance limits in CY moduli space
Authors: Angius Roberta 
Published: September 2024

Abstract
Dynamical Cobordism provides a powerful method to probe infinite distance limits in moduli/field spaces parameterized by scalars constrained by generic potentials, employing configurations of codimension-1 end of the world (ETW) branes. These branes, characterized in terms of critical exponents, mark codimension-1 boundaries in the spacetime in correspondence of finite spacetime distance singularities at which the scalars diverge. Using these tools, we explore the network of infinite distance singularities in the complex structure moduli space of Calabi-Yau fourfolds compactifications in M-theory with a four-form flux turned on, which is described in terms of normal intersecting divisors classified by asymptotic Hodge theory. We provide spacetime realizations for these loci in terms of networks of intersecting codimension-1 ETW branes classified by specific critical exponents which encapsulate the relevant information of the asymptotic Hodge structure characterizing the corresponding divisors.
Fazekas scale magnetic resonance imaging assessment in Alzheimer’s disease and primary age-related tauopathy
Authors: Quintas-Neves Miguel , Almeida Francisco C. , Gauthreaux Kathryn , Teylan Merilee A. , Mock Charles N. , Kukull Walter A. , Crary John F. , Oliveira Tiago Gil 
Published: September 2024

Abstract
Background
Brain vascular pathology is an important comorbidity in Alzheimer’s disease (AD), with white matter damage independently predicting cognitive impairment. However, it is still unknown how vascular pathology differentially impacts primary age-related tauopathy (PART) compared to AD. Therefore, our objectives were to compare the brain microangiopathic burden in patients with PART and AD, evaluated by MRI, while assessing its relation with neuropathological findings, patterns of brain atrophy and degree of clinical impairment.

Methods
Clinical information, brain MRI (T1 and T2-FLAIR) and neuropathological data were obtained from the National Alzheimer’s Coordinating Centre ongoing study, with a total sample of 167 patients identified, that were divided according to the presence of neuritic plaques in Consortium to Establish a Registry for Alzheimer’s disease (CERAD) 0 to 3. Microangiopathic burden and brain atrophy were evaluated by two certified neuroradiologists, using, respectively, the Fazekas score and previously validated visual rating scales to assess brain regional atrophy.

Results
Significant correlations were found between the Fazekas score and atrophy in the fronto-insular and medial temporal regions on both groups, with PART showing overall stronger positive correlations than in AD, especially in the fronto-insular region. For this specific cohort, no significant correlations were found between the Fazekas score and the degree of clinical impairment.

Conclusion
Our results show that PART presents different pathological consequences at the brain microvascular level compared with AD and further supports PART as an independent pathological entity from AD.
A Framework for Estimating Economic Impacts of Ecological Restoration
Authors: Thomas Catherine Cullinane , Huber Christopher , Skrabis Kristin E. , Hoelzle Timothy B. 
Published: September 2024

AbstractEcological restoration projects are designed to improve natural and cultural resources. Spending on restoration also stimulates economic impacts to the restoration economy through the creation or support of jobs and business activity. This paper presents accessible methods for quantifying the economic impacts supported by restoration spending and is written to be a guide and toolbox for an interdisciplinary audience of restoration practitioners and economists. Measuring the economic impacts of restoration can be challenging due to lacking or limited data. The complex, collaborative, and heterogeneous nature of restoration projects can make it difficult to clearly track costs, contributing to limited availability and inconsistency in restoration cost data. And business classification systems, such as the North American Industrial Classification System (NAICS), do not include restoration-sectors that consistently describe the patterns of restoration spending. The aims of this paper are to (1) provide restoration practitioners and program managers with a clear understanding of the application of economic impact analyses to restoration, (2) provide a framework for collecting project cost data for economic impact analyses, and (3) provide modeling best practices and an example application of the framework.
Posterior approaches to the acetabulum
Authors: Staresinic Mario , Lindtner Richard A. , Krappinger Dietmar , Gänsslen Axel 
Published: September 2024

AbstractPosterior approaches, particularly the Kocher-Langenbeck approach, remain the workhorses in the treatment of acetabular fractures. Various modifications have been developed, each offering specific advantages depending on surgical requirements. The modified Gibson approach, for example, is suggested to provide enhanced visualization of the superior acetabulum, although recent cadaveric studies have not consistently substantiated this benefit. The Ganz approach, which involves bigastric trochanteric osteotomy with safe surgical hip dislocation, is particularly advantageous for managing complex and comminuted posterior acetabular fractures, as it enables a 360° view of the acetabulum and femoral head. Overall, posterior approaches are associated with low rates of complications, with heterotopic ossification being the most prevalent. The choice of surgical approach and patient positioning should be guided by the surgeon’s preference and expertise, tailored to the specific fracture pattern and patient characteristics.