bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study
Authors: Liu Gang , Zong Geng , Doty Richard L , Sun Qi 
Published: November 2016

ObjectivesTo estimate the prevalence of, and explore potential risk factors for, taste and smell dysfunction in the general population of the USA.DesignA cross-sectional study.SettingA cross-sectional analysis of data collected in the National Health and Nutrition Examination Survey (NHANES 2013–2014).ParticipantsA total of 3519 men and women aged 40 years and older who participated in NHANES 2013–2014.Main outcome measuresUsing the NHANES Pocket Smell Test, smell impairment was defined as failing to correctly identify 6 or more of the 8 odours. Taste impairment was defined as failing to correctly identify quinine or sodium chloride.ResultsThe estimated prevalence was 13.5% for smell impairment, 17.3% for taste impairment and 2.2% for taste and smell impairment. For smell, but not taste, prevalence estimates increased with age and were higher in men and ethnic minorities. In backward stepwise logistic regression, low educational attainment, low family income and a history of asthma or cancer were independently associated with a higher prevalence of smell impairment, whereas light-to-moderate alcohol consumption (1–3 drinks/day) was associated with a lower prevalence of this condition. After multivariate adjustment, being non-Hispanic Black Americans, consuming ≥4 drinks of alcohol per day and having a history of cardiovascular disease (CVD) were independently associated with a higher prevalence of taste impairment.ConclusionsBased on a nationally representative multistage probability survey among the US population aged 40 years and older, smell and taste dysfunction affected ∼20.5 million (13.5%) and 26.3 million (17.3%) individuals, respectively. Age, gender, ethnicity, educational attainment, family income, light-to-moderate alcohol consumption and history of asthma or cancer were significant risk factors for smell dysfunction, whereas only ethnicity, heavy alcohol consumption and CVD history were associated with a higher prevalence of taste dysfunction.
BDNF effects on functional recovery across motor behaviors after cervical spinal cord injury
Authors: Hernandez-Torres Vivian , Gransee Heather M. , Mantilla Carlos B. , Wang Yao , Zhan Wen-Zhi , Sieck Gary C. 
Published: November 2016

Unilateral C2cervical spinal cord hemisection (SH) disrupts descending excitatory drive to phrenic motor neurons, thereby paralyzing the ipsilateral diaphragm muscle (DIAm) during ventilatory behaviors. Recovery of rhythmic DIAm activity ipsilateral to injury occurs over time, consistent with neuroplasticity and strengthening of spared synaptic inputs to phrenic motor neurons. Localized intrathecal delivery of brain-derived neurotrophic factor (BDNF) to phrenic motor neurons after SH enhances recovery of eupneic DIAm activity. However, the impact of SH and BDNF treatment on the full range of DIAm motor behaviors has not been fully characterized. We hypothesized that all DIAm motor behaviors are affected by SH and that intrathecal BDNF enhances the recovery of both ventilatory and higher force, nonventilatory motor behaviors. An intrathecal catheter was placed in adult, male Sprague-Dawley rats at C4to chronically infuse artificial cerebrospinal fluid (aCSF) or BDNF. DIAm electromyography (EMG) electrodes were implanted bilaterally to record activity across motor behaviors, i.e., eupnea, hypoxia-hypercapnia (10% O2and 5% CO2), sighs, airway occlusion, and sneezing. After SH, ipsilateral DIAm EMG activity was evident in only 43% of aCSF-treated rats during eupnea, and activity was restored in all rats after BDNF treatment. The amplitude of DIAm EMG (root mean square, RMS) was reduced following SH during eupnea and hypoxia-hypercapnia in aCSF-treated rats, and BDNF treatment promoted recovery in both conditions. The amplitude of DIAm RMS EMG during sighs, airway occlusion, and sneezing was not affected by SH or BDNF treatment. We conclude that the effects of SH and BDNF treatment on DIAm activity depend on motor behavior.NEW & NOTEWORTHY This study demonstrates that after unilateral C2spinal cord hemisection (SH), there are differences in the spontaneous recovery of diaphragm (DIAm) electromyographic activity during ventilatory compared with more forceful, nonventilatory motor behaviors. Furthermore, we show that intrathecal delivery of brain-derived neurotrophic factor (BDNF) at the level of the phrenic motor neuron pool enhances recovery of ipsilateral DIAm activity following SH, exerting main effects on recovery of ventilatory but not higher force, nonventilatory behaviors.
Biomarkers of Tobacco Exposure: Summary of an FDA-Sponsored Public Workshop
Authors: Chang Cindy M. , Edwards Selvin H. , Arab Aarthi , Del Valle-Pinero Arseima Y. , Yang Ling , Hatsukami Dorothy K. 
Published: November 2016

Abstract
Since 2009, the FDA Center for Tobacco Products (CTP) has had the authority to regulate the manufacturing, distribution, and marketing of tobacco products in order to reduce the death and disease caused by tobacco use. Biomarkers of exposure pertain to actual human exposure to chemicals arising from tobacco use and could play an important role across a number of FDA regulatory activities, including assessing new and modified-risk tobacco products and identifying and evaluating potential product standards. On August 3–4, 2015, FDA/CTP hosted a public workshop focused on biomarkers of exposure with participants from government, industry, academia, and other organizations. The workshop was divided into four sessions focused on: (i) approaches to evaluating and selecting biomarkers; (ii) biomarkers of exposure and relationship to disease risk; (iii) currently used biomarkers of exposure and biomarkers in development; and (iv) biomarkers of exposure and the assessment of smokeless tobacco and electronic nicotine delivery systems. This article synthesizes the main findings from the workshop and highlights research areas that could further strengthen the science around biomarkers of exposure and help determine their application in tobacco product regulation. Cancer Epidemiol Biomarkers Prev; 26(3); 291–302. ©2016 AACR.
Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia
Authors: Pikman Yana , Alexe Gabriela , Roti Giovanni , Conway Amy Saur , Furman Andrew , Lee Emily S. , Place Andrew E. , Kim Sunkyu , Saran Chitra , Modiste Rebecca , Weinstock David M. , Harris Marian , Kung Andrew L. , Silverman Lewis B. , Stegmaier Kimberly 
Published: November 2016

Abstract
Purpose: Although significant progress has been made in the treatment of T-cell acute lymphoblastic leukemia (T-ALL), many patients will require additional therapy for relapsed/refractory disease. Cyclin D3 (CCND3) and CDK6 are highly expressed in T-ALL and have been effectively targeted in mutant NOTCH1-driven mouse models of this disease with a CDK4/6 small-molecule inhibitor. Combination therapy, however, will be needed for the successful treatment of human disease.
Experimental Design: We performed preclinical drug testing using a panel of T-ALL cell lines first with LEE011, a CDK4/6 inhibitor, and next with the combination of LEE011 with a panel of drugs relevant to T-ALL treatment. We then tested the combination of LEE011 with dexamethasone or everolimus in three orthotopic mouse models and measured on-target drug activity.
Results: We first determined that both NOTCH1-mutant and wild-type T-ALL are highly sensitive to pharmacologic inhibition of CDK4/6 when wild-type RB is expressed. Next, we determined that CDK4/6 inhibitors are antagonistic when used either concurrently or in sequence with many of the drugs used to treat relapsed T-ALL (methotrexate, mercaptopurine, asparaginase, and doxorubicin) but are synergistic with glucocorticoids, an mTOR inhibitor, and gamma secretase inhibitor. The combinations of LEE011 with the glucocorticoid dexamethasone or the mTOR inhibitor everolimus were tested in vivo and prolonged survival in three orthotopic mouse models of T-ALL. On-target activity was measured in peripheral blood and tissue of treated mice.
Conclusions: We conclude that LEE011 is active in T-ALL and that combination therapy with corticosteroids and/or mTOR inhibitors warrants further investigation. Clin Cancer Res; 23(4); 1012–24. ©2016 AACR.
See related commentary by Carroll et al., p. 873
Redescription of four species of Cytaea Keyserling, 1882 (Araneae: Salticidae)
Authors: TRĘBICKI ŁUKASZ , PATOLETA BARBARA M. , GARDZIŃSKA JOANNA 
Published: November 2016

Four species of Cytaea Keyserling, 1882 are diagnosed, redescribed, and illustrated: C. laticeps (Thorell, 1878), C. nimbata (Thorell, 1881), C. rubra (Walckenaer, 1837), and C. sinuata (Doleschall, 1859).
Differences in the Initiation and Development of the Madden–Julian Oscillation over the Indian Ocean Associated with Two Types of El Niño
Authors: Hsu Pang-Chi , Xiao Ting 
Published: November 2016

Abstract
The influences of different types of Pacific warming, often classified as the eastern Pacific (EP) and central Pacific (CP) El Niño events, on Madden–Julian oscillation (MJO) activity over the Indian Ocean were investigated. Accompanied by relatively unstable (stable) atmospheric stratification induced by enhanced (reduced) moisture and moist static energy (MSE) in the lower troposphere, strengthened (weakened) MJO convection was observed in the initiation and eastward-propagation stages during CP (EP) El Niño events. To examine the key processes resulting in the differences in low-level moistening and column MSE anomalies over the Indian Ocean associated with the two types of El Niño, the moisture and column MSE budget equations were diagnosed using the reanalysis dataset ERA-Interim. The results indicate that the enhanced horizontal advection in the CP El Niño years plays an important role in causing a larger moisture and MSE growth rate over the MJO initiation area during CP El Niño events than during EP El Niño events. The increases in horizontal moisture and MSE advection primarily result from advection by mean flow across the enhanced intraseasonal moisture and MSE gradient, as well as by intraseasonal circulation across the mean moisture and MSE gradient associated with the CP El Niño. In the eastward development stage, the enhanced preconditioning comes from positive moisture and MSE advection anomalies in the CP El Niño events. Meanwhile, the strengthened MJO-related convection over the central-eastern Indian Ocean is maintained by increased atmospheric radiative heating and surface latent heat flux during the CP El Niño compared to the EP El Niño events.
Future Response of Temperature and Precipitation to Reduced Aerosol Emissions as Compared with Increased Greenhouse Gas Concentrations
Authors: Acosta Navarro Juan C. , Ekman Annica M. L. , Pausata Francesco S. R. , Lewinschal Anna , Varma Vidya , Seland Øyvind , Gauss Michael , Iversen Trond , Kirkevåg Alf , Riipinen Ilona , Hansson Hans Christen 
Published: November 2016

Abstract
Experiments with a climate model (NorESM1) were performed to isolate the effects of aerosol particles and greenhouse gases on surface temperature and precipitation in simulations of future climate. The simulations show that by 2025–49 a reduction of aerosol emissions from fossil fuels following a maximum technically feasible reduction (MFR) scenario could lead to a global and Arctic warming of 0.26 and 0.84 K, respectively, as compared with a simulation with fixed aerosol emissions at the level of 2005. If fossil fuel emissions of aerosols follow a current legislation emissions (CLE) scenario, the NorESM1 model simulations yield a nonsignificant change in global and Arctic average surface temperature as compared with aerosol emissions fixed at year 2005. The corresponding greenhouse gas effect following the representative concentration pathway 4.5 (RCP4.5) emission scenario leads to a global and Arctic warming of 0.35 and 0.94 K, respectively. The model yields a marked annual average northward shift in the intertropical convergence zone with decreasing aerosol emissions and subsequent warming of the Northern Hemisphere. The shift is most pronounced in the MFR scenario but also visible in the CLE scenario. The modeled temperature response to a change in greenhouse gas concentrations is relatively symmetric between the hemispheres, and there is no marked shift in the annual average position of the intertropical convergence zone. The strong reduction in aerosol emissions in the MFR scenario also leads to a net southward cross-hemispheric energy transport anomaly both in the atmosphere and ocean, and enhanced monsoon circulation in Southeast Asia and East Asia causing an increase in precipitation over a large part of this region.
Identification of Heschl’s gyrus on phase difference enhanced imaging
Authors: Ide Satoru , Kakeda Shingo , Yoneda Tetsuya , Watanabe Keita , Futatsuya Koichiro , Murakami Yu , Moriya Junji , Ogasawara Atsushi , Sato Toru , Korogi Yukunori 
Published: November 2016

Background The white matter in the Heschl’s gyrus (HG-WM) may appear differently to the other gyri on phase difference enhanced imaging (PADRE), which can enhance the myelin density. Purpose To evaluate the signal intensity (SI) of HG-WM using the PADRE technique and to compare the images with susceptibility-weighted imaging (SWI)-like images. Material and Methods The participants included 19 normal controls (38 HGs; mean age, 60.1 years; age range, 28–80 years). Coronal PADRE and SWI-like images were acquired using a 3T magnetic resonance (MR) system. The SI of the HG-WM was classified into three grades based on a comparison with the SI of the superior temporal gyrus: Grade 1, isointense; Grade 2, slightly hypointense, and Grade 3, markedly hypointense. Results In the assessment of the SI of the HG-WM, the HG-WM appeared hypointense in all 38 sites of the 19 participants; the hypointensity corresponded to Grade 2 in 13 (34%) images and Grade 3 in 25 (66%) images. On the other hand, the HG-WM was classified as Grade 1 (isointense) in all of the SWI-like images. Conclusion The HG-WM appears hypointense on PADRE, which probably reflects the higher myelin content. PADRE may be useful for identifying the HG through the assessment of the SI of the HG-WM.
Sweet Trouble: Coleridge, Demoralized
Authors: Murphy Peter 
Published: November 2016

AbstractIn the late 1790s Wordsworth and Coleridge conduct a common storytelling experiment: to see if stories can tell their own meaning, without explanations or morals attached. The resulting stories are, fundamentally, rewrites of the stories of sentimental encounter so common in the previous generation. Their two most ambitious experiments of this type are The Ruined Cottage and The Rime of the Ancient Mariner, written at the same time while the poets were in constant conversation. These poems have different fates: Wordsworth worries ever after about the abruptness of the original poem and eventually adds explanations of various types. Coleridge’s gloss to The Rime looks like the result of the same kind of process but, fundamentally, is its opposite: the gloss is a dramatization of the craving for explanation stories generate instead of the explanation itself. In this way Coleridge’s revisions protect rather than undermine the original interest in unexplained storytelling.
The Romanian alternating gender in diachrony and synchrony
Authors: Maiden Martin 
Published: November 2016

AbstractRomanian has a large class of nouns characterized by masculine agreement in the singular and feminine agreement in the plural. This phenomenon ofalternatinggender is frequently argued by traditional grammarians of Romanian, Romance linguists, and linguist typologists to constitute aneuterorthirdgender, distinct frommasculineandfeminine. The present study argues, from close analysis of a wide range of diachronic and comparative dialectal data, that theneuteris in fact an epiphenomenon of agreement behaviour that depends crucially on the inflexional identity of the singular and plural forms of the nouns. Hypostatization of athirdgender is dangerously liable to obfuscate the true mechanisms at work. Principled explanations of some apparent exceptions to my overall claim will be offered. I also investigate, however, some ways in which the emergence of a third gender of the type so widely assumed already to exist might be latent in Romanian, and speculate in general on howalternating gendermight emerge diachronically.
Particle placement in Late Modern English and Twentieth-century English: Morpho-syntactic variables
Authors: Rodríguez-Puente Paula 
Published: November 2016

AbstractThis article surveys possible factors affecting particle alternation in British English between 1650 and 1990. When particle verbs are transitive, the speaker is presented with two possible choices: verb-particle-object (VPO) or verb-object-particle (VOP). Research has shown that there are a number of phonological, morphological, semantic and discourse-functional variables which may affect the speaker’s choice. The present article focuses on the influence of six morpho-syntactic variables, namely the noun phrase (NP) type of the direct object (DO), the length of the object, the complexity of the DO, the presence of a directional prepositional phrase (PPdir), the type of determiner of the object NP and the type of particle. The data show that, although the VPO order tends to be the predominant one, some of these variables can determine the type of arrangement selected by the speaker. The results are also compared with previous research on Middle English, Early Modern English and Present-day English, showing that the tendencies observed have changed over time.
Why English is not dead: A rejoinder to Emonds and Faarlund
Authors: Stenbrenden Gjertrud Flermoen 
Published: November 2016

AbstractThis article argues against the claim by Emonds and Faarlund (2014,English: The language of the vikings. Palacký University: Olomouc) that English died out after the Norman Conquest, and was replaced by a North Germanic variety referred to as “Anglicised Norse”, which had been formed in the Danelaw area in a concerted effort by the Norse and Anglo-Saxon populations, presumably to overthrow the ruling French elite. Emonds and Faarlund base their claim on the existence of some 20–25 linguistic features which are said to have been absent from Old English, but which are present in Present-Day English and in Scandinavian languages. This article argues that genetic affiliation cannot be inferred from shared syntactic, morphological or lexical features, which may easily result from independent convergence in historically related languages. The main counter-argument, however, is chronological: the majority of the features adduced are indeed attested in Old English and often in other West Germanic languages also, and hence may not be attributed to Old Norse; nor can features which are not attested in English until late Middle English or early Modern English come from Old Norse. The continuity of English in the written record likewise renders the suggested scenario highly unlikely.
The cognitive plausibility of statistical classification models: Comparing textual and behavioral evidence
Authors: Klavan Jane , Divjak Dagmar 
Published: November 2016

AbstractUsage-based linguistics abounds with studies that use statistical classification models to analyze either textual corpus data or behavioral experimental data. Yet, before we can draw conclusions from statistical models of empirical data that we can feed back into cognitive linguistic theory, we need to assess whether the text-based models are cognitively plausible and whether the behavior-based models are linguistically accurate. In this paper, we review four case studies that evaluate statistical classification models of richly annotated linguistic data by explicitly comparing the performance of a corpus-based model to the behavior of native speakers. The data come from four different languages (Arabic, English, Estonian, and Russian) and pertain to both lexical as well as syntactic near-synonymy. We show that behavioral evidence is needed in order to fine tune and improve statistical models built on data from a corpus. We argue that methodological pluralism is the key for a cognitively realistic linguistic theory.
The usage and spread of sentence-internal capitalization in Early New High German: A multifactorial approach
Authors: Barteld Fabian , Hartmann Stefan , Szczepaniak Renata 
Published: November 2016

AbstractSentence-internal capitalization of nouns is a characteristic of written Standard German. The sixteenth and seventeenth centuries have been identified as the crucial period for the development of this graphemic convention. Previous studies have shown that animacy played a major role in the spread of sentence-internal capitalization. On the basis of the transregional SiGS-corpus consisting of 18 protocols of witch trials (hand-)written between 1588 and 1630, we propose word frequency as an additional factor and test for its interaction with animacy. Our data reveal that the proportion of capitalized words denoting humans and animate concepts increases rapidly, while the capitalization of lexemes referring to concrete and abstract concepts remains stable at a lower level. A binomial mixed-effects model shows a highly significant effect of frequency and a significant interaction between frequency and animacy. In sum, our data show how cognitive, pragmatic, and usage factors conspire in the gradual emergence of a graphemic convention. We therefore argue that the previously neglected graphemic dimension can add important insights to an empirically based theory of the language-cognition interface.
Quantifying polysemy: Corpus methodology for prototype theory
Authors: Glynn Dylan 
Published: November 2016

AbstractThis study addresses the methodological problem of result falsification in Cognitive Semantics, specifically in the descriptive analysis of semasiological variation, or “polysemy”. It argues that manually analysed corpus data can be used to describe models of semantic structure. The method proposed is quantified, permitting repeat analysis. The operationalisation of a semasiological structure employed in the study takes the principle of semantic features and applies them to a contextual analysis of usage-events, associated with the lexeme under scrutiny. The feature analysis, repeated on a large collection of occurrences, results in a set of metadata that constitutes the usage-profile of the lexeme. Multivariate statistics are then employed to identify patterns in those metadata. The case study examines 500 occurrences of the English lexeme