bluuebunny/crossref_metadata_2025_split huggingface dataset:
Succession in family business: multi-source perspectives
Authors: Bozer Gil , Levin Leon , Santora Joseph C. 
Published: June 2017

PurposeDespite the extensive breadth of research into the critical challenge of succession in family business, generational succession in family business has been investigated from predominately one-dimensional perspective. The purpose of this paper is to respond to call for a multi-perspectives examination of leadership succession in order to embrace the dynamic and complex nature of succession in a family business. Accordingly, the authors investigated the key personal and professional factors associated with effective family-business succession across four key stakeholders: incumbent, successor, family, and nonfamily members.Design/methodology/approachThe explanatory research design included 16 interviews in Phase 1 and 41 prospective case study interviews in Phase 2, both with Australian family businesses that had or were about to experience generational transition.FindingsIncumbents and successor interview findings support the benefits of maintaining a cohesive family business, adaptable family culture, and familiness for effective succession. The authors also identified several personal components (e.g. family-business socialization and external experiences) that can help determine the commitment of successors and how this commitment can change once they assume a leadership position. Business size was the professional component supported by incumbent, successor, and nonfamily members as having a significant impact on succession process. As family business grows and becomes more highly complex, a clearly defined set of procedures become imperative.Practical implicationsFamily-business practitioners can apply the findings to manage the processes and expectations of family and the business to achieve effective generational succession and thereby increase the sustainability of the business.Originality/valueThis research provides a coherent and comprehensive understanding of the interdependencies of competing priorities in the complex succession process that is essential for family-business sustainability and performance.
Improving the external financing in independent high-tech SMEs
Authors: Corsi Christian , Prencipe Antonio 
Published: June 2017

Purpose
The purpose of this paper is to study the impact of foreign venture capital (VC)/private equity (PE) ownership and other types of foreign investors on the access to external finance, in terms of credit provision, by the independent high-tech small and medium enterprises (SMEs) in the European context.

Design/methodology/approach
The research methodology is based on the analysis of a panel sample consisting of 1,138 firms from 23 European Union countries for the period 2006-2015. To statistically test the two defined research hypotheses, a panel model was run using 2SLS estimation.

Findings
The findings show that foreign ownership has a positive but partial role in improving the availability of external funding for independent high-tech SMEs. Foreign VC/PE ownership seems to facilitate the global accessibility of external financing but not the access to bank lending; on the contrary, other forms of foreign ownership (excluding VC/PE) seem to increase only the access to bank lending.

Practical implications
In order to open their businesses to a global spectrum of investment opportunities and increase the potentials of full development, small independent entrepreneurs should become attentive to the role of foreign investors. Further, policy actions need to stimulate an international vision of the way of doing business among the entrepreneurial contexts of high-tech SMEs.

Originality/value
The research fills a literature gap on the role of foreign ownership in mitigating the financing limitations of independent high-tech SMEs. Additionally, as independent high-tech SMEs differ from non-independent firms, the financing constraints and information asymmetry faced by independent firms are critical and pivotal to explore.
Towards inclusive occupational therapy: Introducing the CORE approach for inclusive and occupation‐focused practice
Authors: Pereira Robert B. 
Published: June 2017

Background/aimOccupation is a human right and a social determinant of health. It is also taken for granted. Having access to, and participating in, occupation, is intricately linked to positive health and wellbeing. Despite theory and evidence to support the link between occupation, health and wellbeing, occupational therapists can struggle with applying an occupation focus in practice and knowing how to use occupational frameworks to enable occupation. The purpose of this paper is to introduce the Capabilities, Opportunities, Resources and Environments (CORE) approach for inclusive and occupation‐focused practice. It provides occupational therapists with a means of operationalising occupational enablement and facilitating social inclusion.MethodsThe CORE approach is introduced by linking its main ideas to Economist and Nobel Prize Laureate Amartya Sen's capabilities approach, as well as findings from the author's doctoral research into entrenched disadvantage and social inclusion. Practical questions guided by the CORE approach's acronym are given to explore how the approach can be utilised alongside other occupational models and frameworks to encourage strategies for effective enablement through occupation for social inclusion.ConclusionAs experts in enabling occupation, occupational therapists can use the CORE approach to design occupation‐focused interventions and promote inclusive occupational therapy.
Mental health education in occupational therapy professional preparation programs: Alignment between clinician priorities and coverage in university curricula
Authors: Scanlan Justin Newton , Meredith Pamela J. , Haracz Kirsti , Ennals Priscilla , Pépin Geneviève , Webster Jayne S. , Arblaster Karen , Wright Shelley ,   The ANZOTMHA Network
Published: June 2017

Background/aimOccupational therapy programs must prepare graduates for work in mental health. However, this area of practice is complex and rapidly changing. This study explored the alignment between educational priorities identified by occupational therapists practising in mental health and level of coverage of these topics in occupational therapy programs in Australia and New Zealand.MethodsSurveys were distributed to heads of all occupational therapy programs across Australia and New Zealand. The survey included educational priorities identified by occupational therapists in mental health from a previous study. Respondents were requested to identify the level of coverage given to each of these priorities within their curriculum. These data were analysed to determine a ranking of educational topics in terms of level of coverage in university programs.ResultsResponses were received for 19 programs from 16 universities. Thirty‐four topics were given ‘High‐level coverage’ in university programs, and these were compared against the 29 topics classified as ‘Essential priorities’ by clinicians. Twenty topics were included in both the ‘Essential priorities’ and ‘High‐level coverage’ categories. Topics considered to be ‘Essential priorities’ by clinicians which were not given ‘High‐level coverage’ in university programs included the following: mental health fieldwork experiences; risk assessment and management; professional self‐care resilience and sensory approaches.ConclusionWhile there appears to be overall good alignment between mental health curricula and priorities identified by practising occupational therapists, there are some discrepancies. These discrepancies are described and establish a strong foundation for further discussion between clinicians, academics and university administration to support curriculum review and revision.
Disciplinary Ordinances for English Armies and Military Change, 1385–1513
Authors: MARTINEZ ANDREW 
Published: June 2017

AbstractThis article analyses three extant sets of English disciplinary ordinances, issued by Richard II, Henry V and Henry VIII. It examines the progression of the English army throughout the period 1385–1513, discussing how the ordinances were necessary for the effective functioning of these armies, how discipline and the ordinances changed throughout this period in reaction to the context of the campaign, and concluding with what these underutilized sources can add to our understanding of late medieval warfare.
Effect of Temperature on Granulocyte and Monocyte Adsorption to Cellulose Acetate Beads
Authors: Nishise Shoichi , Takeda Yuji , Abe Yasuhiko , Sasaki Yu , Nara Hidetoshi , Asao Hironobu , Ueno Yoshiyuki 
Published: June 2017

AbstractGranulocyte and monocyte (GM) adsorptive apheresis (GMA) is an effective therapy for inflammatory disorders including inflammatory bowel disease (IBD). During GMA, the blood of a patient with IBD passes through a column to contact cellulose acetate (CA) beads at a temperature below body temperature, likely close to room temperature. Here we investigated the effect of temperature on GM adsorption to CA beads in vitro. We incubated peripheral blood with and without CA beads at 5°C, 25°C, 37°C, and 43°C and calculated the ratios of adsorbed GMs. The ratios of adsorbed GMs increased as the temperature was raised. Additionally, we measured complement activation fragment concentrations. C3a and C5a concentrations also increased as the temperature was raised, and C5a concentrations had a positive correlation with the ratios of adsorbed GMs. These results suggest that warming the column during GMA might increase GM adsorption to CA beads, thereby enhancing the clinical efficacy of GMA.
ClonEstiMate, a Bayesian method for quantifying rates of clonality of populations genotyped at two‐time steps
Authors: Becheler Ronan , Masson Jean‐Pierre , Arnaud‐Haond Sophie , Halkett Fabien , Mariette Stéphanie , Guillemin Marie‐Laure , Valero Myriam , Destombe Christophe , Stoeckel Solenn 
Published: June 2017

AbstractPartial clonality is commonly used in eukaryotes and has large consequences for their evolution and ecology. Assessing accurately the relative importance of clonal vs. sexual reproduction matters for studying and managing such species. Here, we proposed a Bayesian approach, ClonEstiMate, to infer rates of clonality c from populations sampled twice over a short time interval, ideally one generation time. The method relies on the likelihood of the transitions between genotype frequencies of ancestral and descendent populations, using an extended Wright–Fisher model explicitly integrating reproductive modes. Our model provides posterior probability distribution of inferred c, given the assumed rates of mutation, as well as inbreeding and selfing when occurring. Tested under various conditions, this model provided accurate inferences of c, especially when the amount of information was modest, that is low sample sizes, few loci, low polymorphism and strong linkage disequilibrium. Inferences remained robust when mutation models and rates were misinformed. However, the method was sensitive to moderate frequencies of null alleles and when the time interval between required samplings exceeding two generations. Misinformed rates on mating modes (inbreeding and selfing) also resulted in biased inferences. Our method was tested on eleven data sets covering five partially clonal species, for which the extent of clonality was formerly deciphered. It delivered highly consistent results with previous information on the biology of those species. ClonEstiMate represents a powerful tool for detecting and inferring clonality in finite populations, genotyped with SNPs or microsatellites. It is freely available at https://www6.rennes.inra.fr/igepp_eng/Productions/Software.
Integrated microRNA and gene expression profiling reveals the crucial miRNAs in curcumin anti‐lung cancer cell invasion
Authors: Zhan Jian‐wei , Jiao De‐min , Wang Yi , Song Jia , Wu Jin‐hong , Wu Li‐jun , Chen Qing‐yong , Ma Sheng‐lin 
Published: June 2017

BackgroundCurcumin (diferuloylmethane) has chemopreventive and therapeutic properties against many types of tumors, both in vitro and in vivo. Previous reports have shown that curcumin exhibits anti‐invasive activities, but the mechanisms remain largely unclear.MethodsIn this study, both microRNA (miRNA) and messenger RNA (mRNA) expression profiles were used to characterize the anti‐metastasis mechanisms of curcumin in human non‐small cell lung cancer A549 cell line.ResultsMicroarray analysis revealed that 36 miRNAs were differentially expressed between the curcumin‐treated and control groups. miR‐330‐5p exhibited maximum upregulation, while miR‐25‐5p exhibited maximum downregulation in the curcumin treatment group. mRNA expression profiles and functional analysis indicated that 226 differentially expressed mRNAs belonged to different functional categories. Significant pathway analysis showed that mitogen‐activated protein kinase, transforming growth factor‐β, and Wnt signaling pathways were significantly downregulated. At the same time, axon guidance, glioma, and ErbB tyrosine kinase receptor signaling pathways were significantly upregulated. We constructed a miRNA gene network that contributed to the curcumin inhibition of metastasis in lung cancer cells. let‐7a‐3p, miR‐1262, miR‐499a‐5p, miR‐1276, miR‐331‐5p, and miR‐330‐5p were identified as key microRNA regulators in the network. Finally, using miR‐330‐5p as an example, we confirmed the role of miR‐330‐5p in mediating the anti‐migration effect of curcumin, suggesting the importance of miRNAs in the regulation of curcumin biological activity.ConclusionOur findings provide new insights into the anti‐metastasis mechanism of curcumin in lung cancer.
Context‐induced relapse to cocaine seeking after punishment‐imposed abstinence is associated with activation of cortical and subcortical brain regions
Authors: Pelloux Yann , Hoots Jennifer K. , Cifani Carlo , Adhikary Sweta , Martin Jennifer , Minier‐Toribio Angelica , Bossert Jennifer M. , Shaham Yavin 
Published: June 2017

AbstractWe recently developed a rat model of context‐induced relapse to alcohol seeking after punishment‐imposed abstinence to mimic relapse after self‐imposed abstinence due to adverse consequences of drug use. Here, we determined the model's generality to cocaine and have begun to explore brain mechanisms of context‐induced relapse to cocaine seeking after punishment‐imposed abstinence, using the activity marker Fos. In exp. 1, we trained rats to self‐administer cocaine (0.75 mg/kg/infusion, 6 hours/day, 12 days) in context A. Next, we transferred them to context B where for the paired group, but not unpaired group, 50 percent of cocaine‐reinforced lever presses caused aversive footshock. We then tested the rats for cocaine seeking under extinction conditions in contexts A and B. We also retested them for relapse after retraining in context A and repunishment in context B. In exp. 2, we used Fos immunoreactivity to determine relapse‐associated neuronal activation in brain regions of rats exposed to context A, context B or neither context. Results showed the selective shock‐induced suppression of cocaine self‐administration and context‐induced relapse after punishment‐imposed abstinence in rats exposed to paired, but not unpaired, footshock. Additionally, context‐induced relapse was associated with selective activation of dorsal and ventral medial prefrontal cortex, anterior insula, dorsal striatum, basolateral amygdala, paraventricular nucleus of the thalamus, lateral habenula, substantia nigra, ventral subiculum, and dorsal raphe, but not nucleus accumbens, central amygdala, lateral hypothalamus, ventral tegmental area and other brain regions. Together, context‐induced relapse after punishment‐imposed abstinence generalizes to rats with a history of cocaine self‐administration and is associated with selective activation of cortical and subcortical regions.
Clinical and palliative care outcomes for patients of poor performance status treated with antiprogrammed death‐1 monoclonal antibodies for advanced melanoma
Authors: Wong Annie , Williams Molly , Milne Donna , Morris Kortnye , Lau Peter , Spruyt Odette , Fullerton Sonia , McArthur Grant 
Published: June 2017

AbstractBackgroundAntiprogrammed death‐1 antibodies (anti‐PD1) have response rates of 40% in metastatic melanoma. Patients with poor performance status (PS) were excluded from clinical trials, yet use of anti‐PD1 is widespread in clinical practice. Literature regarding clinical and palliative care outcomes in patients with poor PS treated with anti‐PD1 is lacking.MethodsRetrospective review of outcomes for all patients with advanced melanoma treated with anti‐PD1 between 2012 and June 2015 at Peter MacCallum Cancer Centre, a tertiary specialist cancer center in Australia.ResultsBetween 2012 and 2015, 91 patients received anti‐PD1: median age 63, 65% males, 77% elevated LDH>1xULN (37/48 patients). Fifty‐eight patients had baseline ECOG PS of 0–1 (64%), 24 patients ECOG PS 2–3 (26%) and ECOG PS was not recorded in nine patients (10%). Median overall survival (OS) for the ECOG PS 0–1 group was 19.5 months and 1.8 months for ECOG PS 2–3 (HR 5.5; 95% CI, 9.1–50.3; P = 0.0001). Tumor response was 23/58 (39%) in ECOG PS 0–1, 2/16 (12%) in ECOG PS 2 and 0/8 in ECOG PS 3. Toxicity did not differ between different groups. ECOG PS 2–3 patients were more likely to be treated and hospitalized within the last month of life compared to ECOG PS 0–1 patients, RR 1.75 (95% CI, 1.04–2.56, P = 0.019) and RR 1.73 (95% CI, 1.10–2.16, P = 0.009), respectively. ECOG PS 2–3 patients were more likely to die in an acute hospital RR 2.68 (95% CI, 1.17–6.51, P = 0.016).ConclusionsPatients with poor baseline PS have a significantly lower OS and reduced response to anti‐PD1. Further quality of life and palliative care research is needed.
Predictors of visual outcome in patients operated for craniopharyngioma – a Danish national study
Authors: Jacobsen Mads Forslund , Thomsen Ann Sofia Skou , Bach‐Holm Daniella , Doroudian Ghazaleh , Nissen Kamilla Rothe , Fugleholm Kåre , Poulsgaard Lars , Siersma Volkert , Heegaard Steffen 
Published: June 2017

AbstractPurposeCraniopharyngioma often causes visual loss due to the close relation to the anterior visual pathways. This study investigates the incidence and predictors of visual outcomes in patients with craniopharyngioma.MethodsData from sixty‐six patients who underwent surgery for craniopharyngioma from 2009 to 2013 in Denmark were reviewed. Primary outcomes were visual acuity (VA) and visual field (VF) defects from pre‐and postoperative visits. Secondary outcomes were optic nerve atrophy (OA) and papilledema.ResultsFifty‐eight patients were included. The VA of the patients 1‐year after surgery improved by −0.16 log(MAR) (95%CI: −0.30 to −0.02; p = 0.0266). Visual field (VF) defects worsened in 17 eyes (30%), remained stable in 21 eyes (37%) and improved in 19 eyes (33%). The presence of papilledema and the absence of OA were significantly correlated with an improvement in VA postoperatively (p = 0.011 and p = 0.011, respectively). Patients undergoing surgery within a week or less after their first ophthalmological examination had a significant improvement in VA (−0.36; 95%CI: −0.62 to −0.09; p = 0.0099). Patients undergoing surgery using a subfrontal approach also showed improvement in VA (p = 0.048). Tumour recurrence had a significantly worse VA outcome (p = 0.0074).ConclusionPatients show a slight improvement in VA 1‐year after operation for craniopharyngioma. The presence of papilledema and early surgical intervention is associated with a significant improvement in VA. Early involvement of a dedicated ophthalmologist is recommended to secure an early detection of a visual decline and potential tumour recurrence.
Delays in the diagnosis and initial treatment of bladder cancer in Western Australia
Authors: McCombie Steve P. , Bangash Haider K. , Kuan Melvyn , Thyer Isaac , Lee Fran , Hayne Dickon 
Published: June 2017

ObjectivesTo quantify and examine the causes of delays in the diagnosis and initial treatment of patients with bladder cancer in Western Australia.Subjects and MethodsAll attendances at a one‐stop haematuria clinic at a public tertiary‐level hospital in Western Australia between May 2008 and April 2014 were reviewed retrospectively. All patients diagnosed with a bladder tumour over this period were identified. These patients and their general practitioners were contacted retrospectively and invited to participate in telephone interviews, with additional data collected from clinical records as required. Waiting times to presentation, referral, assessment, and initial treatment were established for patients who presented with visible haematuria.ResultsOf 1 365 attendances, 151 patients were diagnosed with a bladder tumour and 100 of these were both suitable and agreed to participate in the study. For patients with visible haematuria the median (range) waiting time from initial bleeding to surgery was 69.5 (9–1 165) days. This was comprised of a median (range) pre‐referral waiting time of 12 (0–1 137) days, assessment waiting time of 23.5 (0–207) days, and treatment waiting time of 20 (1–69) days. Reasons for prolonged waiting times included poor public awareness, patient fear and anxiety, delayed and non‐referral from primary care, administrative delays, and resource limitations.ConclusionMany patients experience significant delays in the diagnosis and treatment of their bladder cancer in Western Australia, and this probably reflects national trends. These concerning data warrant consideration of how delays can be reduced to improve outcomes for these patients.