bluuebunny/crossref_metadata_2025_split huggingface dataset:
The CHEVI tethering complex: facilitating special deliveries
Authors: Rogerson Clare , Gissen Paul 
Published: August 2016

AbstractVPS33B and VIPAR comprise the two known components of the recently christened class C Homologues in Endosome–Vesicle Interaction (CHEVI) complex, thought to act as a tethering complex in endosomal trafficking distinct from the HOPS and CORVET complexes in mammalian cells. A recent paper in The Journal of Pathology further explores the role of the CHEVI complex in the biogenesis of α‐granules in megakaryocytes, identifying two novel interactors of this complex: α‐tubulin and SEC22B, and demonstrating that VPS33B expression is required for the localization of SEC22B and the α‐granule cargo VWF to proplatelets in megakaryocytes. These findings advance the current knowledge of the function of the CHEVI complex in α‐granule biogenesis and together with studies in other systems, corroborate its role in the specialized delivery of cargo in different cell types. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Macrophage‐mediated psoriasis can be suppressed by regulatory T lymphocytes
Authors: Leite Dantas Rafael , Masemann Dörthe , Schied Tanja , Bergmeier Vera , Vogl Thomas , Loser Karin , Brachvogel Bent , Varga Georg , Ludwig Stephan , Wixler Viktor 
Published: August 2016

AbstractWe recently described an inducible human TNF transgenic mouse line (ihTNFtg) that develops psoriasis‐like arthritis after doxycycline stimulation and analysed the pathogenesis of arthritis in detail. Here, we show that the skin phenotype of these mice is characterized by hyperproliferation and aberrant activation of keratinocytes, induction of pro‐inflammatory cytokines, and infiltration with Th1 and Treg lymphocytes, particularly with macrophage infiltration into lesional skin, thus pointing to a psoriasis‐like phenotype. To reveal the contribution of T cells and macrophages to the development of TNF‐mediated psoriasis, ihTNFtg mice were crossbred into RAG1KO mice lacking mature T and B cells. Surprisingly, the psoriatic phenotype in the double mutants was not reduced; rather, it was enhanced. The skin showed significantly increased inflammation and in particular, increased infiltration by macrophages. Consequently, depletion of macrophages in RAG1KO or wild‐type mice led to decreased disease severity. On the contrary, depletion of Treg cells in wild‐type mice increased both psoriasis and the number of infiltrating macrophages, while adoptive transfer of Foxp3‐positive cells into RAG1KO or wild‐type mice decreased both the development of psoriasis and macrophage infiltration. Thus, we conclude that Treg lymphocytes inhibit the pro‐inflammatory activity of macrophages, which are the major immune effector cells in hTNF‐mediated psoriasis. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Measuring the efficacy of a project for adolescents and young adults with cancer: A study from the Milan Youth Project
Authors: Ferrari Andrea , Silva Matteo , Veneroni Laura , Magni Chiara , Clerici Carlo Alfredo , Meazza Cristina , Terenziani Monica , Spreafico Filippo , Chiaravalli Stefano , Casanova Michela , Luksch Roberto , Catania Serena , Schiavello Elisabetta , Biassoni Veronica , Podda Marta , Bergamaschi Luca , Puma Nadia , Indini Alice , Proserpio Tullio , Massimino Maura 
Published: August 2016

ABSTRACTBackgroundVarious projects dedicated specifically to adolescents and young adults (AYA) with cancer have been developed in recent years. A critical aspect of such programs is the ability to demonstrate its value, and therefore how to measure desired outcomes.MethodsA list of metrics to consider for demonstrating the advantages of an AYA program was identified and used to assess the activity of the Youth Project operating at the Pediatric Oncology Unit of the Istituto Nazionale Tumori in Milan.ResultsThe number of newly diagnosed AYA patients seen at the Unit has increased since the formal launch of the Youth Project, from 65 to 81.2 cases/year. Concerning the 78 AYA patients presenting with malignant neoplasms in 2015, 82% were included in clinical trials (the other 18% in prospective observational studies). Fertility preservation measures were implemented for 59% of AYA patients considered at risk, and specific psychological support was provided in 70.6% of cases; 72.5% of patients actively participated in support activities. Other parameters considered were a preliminary satisfaction questionnaire administered to patients and the program's scientific recognition and acknowledgment by the community.ConclusionsThe study proposed a number of potentially reproducible, practical parameters to consider in assessing the value of a program dedicated to AYA. These metrics were examined in terms of the activities of our Youth Project, and confirmed its efficacy. To be sustainable over time, AYA projects have to be accepted as a standard of care at the community and government levels.
Role of neuroimaging in children with acute lymphoblastic leukemia and central nervous system involvement at diagnosis
Authors: Ranta Susanna , Palomäki Maarit , Levinsen Mette , Taskinen Mervi , Abrahamsson Jonas , Mellgren Karin , Niinimäki Riitta , Schmiegelow Kjeld , Heyman Mats , Harila‐Saari Arja ,   on behalf of the Nordic Society of Pediatric Hematology and Oncology (NOPHO)
Published: August 2016

AbstractBackgroundEach year approximately 200 children and adolescents are diagnosed with acute lymphoblastic leukemia (ALL) in the five Nordic countries, and 3% of these have central nervous system (CNS) involvement confirmed by leukemic cells in the cerebrospinal fluid (CSF) or neurological symptoms. We sought to determine the significance of neuraxis imaging in such patients.ProcedureMagnetic resonance images of children aged 1–17.9 with CNS leukemia at diagnosis of ALL were centrally reviewed and clinical data were retrieved from the medical records and the Nordic leukemia registry. Patients were diagnosed in the period 2000–2012 in Sweden, Finland, or Denmark.ResultsThe cohort comprised 1,877 patients, and 66 (3.5%) had CNS involvement. Forty‐five percent (30/66) had CNS related symptoms. Symptoms included vomiting, facial palsy, headache, visual symptoms, and impaired hearing. CNS imaging was performed in 32 of 66 children (48%), and confirmed CNS involvement in 6 of 21 patients with symptoms (29%) and 5 of 11 (45%) without (P = 0.44). There was no difference in the overall survival between CNS‐positive patients with and without signs of leukemic involvement by imaging (P = 0.53).ConclusionsRadiological imaging of asymptomatic children with CNS leukemia at diagnosis lacks clinical importance, but may be useful in patients with cranial nerve symptoms and negative CSF, as well as for follow‐up. Imaging of symptomatic patients is warranted in order to exclude other causes underlying the symptoms.
Excellent remission rates with limited toxicity in relapsed/refractory Langerhans cell histiocytosis with pulse dexamethasone and lenalidomide in children
Authors: Uppuluri Ramya , Ramachandrakurup Sreejith , Subburaj Divya , Bakane Atish , Raj Revathi 
Published: August 2016

AbstractRefractory/relapsed Langerhans cell histiocytosis (LCH) has a difficult course with a guarded prognosis. We used a novel protocol including six cycles of pulse dexamethasone and lenalidomide in four children with LCH refractory to first‐line agents and courses of cladribine and cytarabine or single‐agent cladribine. All four children completed the protocol without any significant adverse effects and remain in complete and durable remission 15–18 months posttreatment. The novel protocol we propose for relapsed/refractory LCH is cost‐effective and outpatient‐based with durable remission and minimal toxicity. This is particularly suited for resource‐limited settings.
Theoretical studies on nitrogen‐rich furoxan‐based heterocyclic derivatives
Authors: Li Xiao‐Hong , Ju Wei‐Wei , Zhang Rui‐Zhou 
Published: August 2016

AbstractThe density functional theory method was used to study the heats of formation (HOFs), energetic properties, electronic structure of a series of 4,4″‐dinitro(3,3′:4′,3′′)tris([1,2,5]oxadiazole)‐2′‐oxide (3,4‐bis[4′‐nitrofurazan‐3′‐yl]furoxan) derivatives. The results show that the substitution of the nitro group is very useful for improving their HOFs and detonation performances. The HOFs of the title compounds are all positive and larger than those of 1,3,5‐trinitro‐1,3,5‐triazinane and 1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocane. The analysis of oxygen balance shows that the studied compounds need the oxygen in the explosive. Compound A1 has larger detonation velocity and detonation pressure than those of 1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocane and can be regarded as a potential candidate for high‐energy compounds because of the moderate heat of detonation, high density, and high N. In addition, the energy gaps between the highest occupied molecular orbital and lowest unoccupied molecular orbital of the studied compounds are further investigated.
Effects of wind shear and radiative cooling on the stratocumulus‐topped boundary layer
Authors: Kopec Marta K. , Malinowski Szymon P. , Piotrowski Zbigniew P. 
Published: August 2016

The effects of wind shear and radiative cooling on the stratocumulus‐topped boundary layer (STBL) were investigated via a set of large‐eddy simulations. The set‐up of the numerical experiments was based on Flight TO13 from the Physics of Stratocumulus Top (POST) field campaign, in which sensible and latent heat fluxes at the surface were small and thermodynamic conditions prevented cloud‐top entrainment instability.The results demonstrate that the presence of radiative cooling invigorated convective circulations across the STBL and sharpened the inversion above the cloud, while wind shear at the top of the STBL was a source of turbulence in the capping inversion and caused dilution of the cloud top. The flux and gradient Richardson numbers in the capping inversion and in the topmost layer of the cloud were nearly critical.Analysis of the turbulent kinetic energy (TKE) budget and its transport indicated that turbulence in the inversion capping the cloud was produced locally by wind shear and was dynamically decoupled from the turbulence driven by convective circulations across the STBL. Similar conclusions were derived for the topmost part of the cloud.
Investigation of active tracking for robotic arm assisted magnetic resonance guided focused ultrasound ablation
Authors: Xiao Xu , Huang Zhihong , Rube Martin A. , Melzer Andreas 
Published: August 2016

AbstractBackgroundFocused ultrasound surgery (FUS) is a technique that does not need invasive access to the patient while allowing precise targeted therapy. Magnetic resonance (MR) guided FUS provides capabilities for monitoring treatments. Because the targeted tumours are distributed at different positions, focus repositioning becomes necessary.MethodsAn MR compatible robot was used to increase the operational range of FUS application. Active tracking was developed to detect the robotic arm with regard to the MR coordinate system. The purpose of this study was to construct active tracking to allow a wide spatial range of repositioning the FUS transducer that is fast and accurate. The technique was characterised and validated by a series of positioning tests to prove its efficiency for guiding the robot.ResultsIn the calibration range, tracking achieved an RMS accuracy of 0.63 mm. Results of phantom ablation showed a focal scanning precision Δx = 0.4 ± 0.37 mm, Δy = 0.4 ± 0.28 mm and Δz = 0.7 ± 0.66 mm.ConclusionsThe active tracking localisation can be considered a feasible approach for the MR guided FUS system positioned by a robot. Copyright © 2016 John Wiley & Sons, Ltd.
Reliability and time‐to‐failure bounds for discrete‐time constrained Markov jump linear systems
Authors: Hernández‐Mejías Manuel A. , Sala Antonio 
Published: August 2016

SummaryThis paper presents a methodology to obtain a guaranteed‐reliability controller for constrained linear systems, which switch between different modes according to a Markov chain (Markov jump linear systems). Inside the classical maximal robust controllable set, there is 100% guarantee of never violating constraints at future time. However, outside such set, some sequences might make hitting constraints unavoidable for some disturbance realisations. A guaranteed‐reliability controller based on a greedy heuristic approach was proposed in an earlier work for disturbance‐free, robustly stabilisable Markov jump linear systems. Here, extensions are presented by, first, considering bounded disturbances and, second, presenting an iterative algorithm based on dynamic programming. In non‐stabilisable systems, reliability is zero; therefore, prior results cannot be applied; in this case, optimisation of a mean‐time‐to‐failure bound is proposed, via minor algorithm modifications. Optimality can be proved in the disturbance‐free, finitely generated case. Copyright © 2016 John Wiley & Sons, Ltd.
Modeling and quadratic stabilization of a class of linear uncertain time‐varying systems
Authors: Jetto L. , Orsini V. , Romagnoli R. 
Published: August 2016

SummaryThis paper considers the quadratic stabilization of a class of uncertain linear time‐varying (LTV) continuous‐time plants. The state‐space representation of each plant is based on the physically meaningful assumption of a dynamical matrix containing uncertain elements whose time trajectories are sufficiently smooth to be well described by interval polynomial functions with arbitrarily time varying coefficients. At some isolated time instants, the parameters trajectories can exhibit some first‐kind discontinuities due for example to sharply varying operating conditions. Using a parameter independent Lyapunov function, a quadratically stabilizing dynamic output controller is directly obtained by the solution of some LMIs. A salient feature of the paper is that, unlike all the other existing methods, quadratic stabilization can be achieved over possibly arbitrarily large uncertain domains of parameters. Copyright © 2016 John Wiley & Sons, Ltd.
Design of a new CP‐ABE with constant‐size secret keys for lightweight devices using elliptic curve cryptography
Authors: Odelu Vanga , Das Ashok Kumar 
Published: August 2016

AbstractThe energy cost of public‐key cryptography is a vital component of modern secure communications. It inhibits the widespread adoption within the ultra‐low energy regimes (for example, implantable medical devices and Radio Frequency Identification tags). In the ciphertext‐policy attribute‐based encryption (CP‐ABE), an encryptor can decide the access policy that who can decrypt the data. Thus, data will be protected from the unauthorized users. However, most of the existing CP‐ABE schemes require huge storage and computational overheads. Moreover, CP‐ABE schemes based on bilinear map loose high efficiency over the elliptic curve cryptography because of the requirement of the security parameters of larger size. These drawbacks prevent the use of ultra‐low energy devices in practice. In this paper, we aim to propose a novel expressive AND gate access structured CP‐ABE scheme with constant‐size secret keys (CSSK) with cost‐efficient solutions for encryption and decryption using elliptic curve cryptography, called the CP‐ABE‐CSSK scheme. In the proposed CP‐ABE‐CSSK, the size of the secret key is as small as 320 bits. In addition, elliptic curve cryptography is efficient and more suitable for lightweight devices as compared with bilinear pairing‐based cryptosystem. Thus, the proposed CP‐ABE‐CSSK scheme provides low computation and storage overheads with an expressive AND gate access structure as compared with related existing schemes. Consequently, our scheme becomes very practical for CP‐ABE key storage and computation cost for ultra‐low energy devices. Copyright © 2016 John Wiley & Sons, Ltd.
Cytotoxicity and Anti–inflammation Profiles of Synthesized Thiazoles‐Based N‐Bisphosphonates and Relevant Bisphosphonic acids
Authors: Abdou Wafaa M. , Barghash Reham F. , Bekheit Mohamed S. , Geronikaki Athina 
Published: August 2016

AbstractA series of substituted thiazole‐bisphosphonates and relevant bisphosphonic acid counterparts was synthesized from the reaction of 2‐chloro‐N‐(substituted)thiazole acetamides with tetraethyl methylene‐1,1‐bisphosphonate reagent in the presence of a base. The reactions proceeded smoothly via nucleophilic substitution to give our targets in good to high yields. Among the products, 4 bisphosphonic acids exhibited excellent anticancer activity vs four tested carcinoma cell lines (MCF7, HELA, DU‐145, and HCT‐116) with GI50 values ranging from 1.8 to 4.8 μMmL−1. According to the prediction results (using PASS program), the same acids and their BP‐analogs were also evaluated for their anti‐inflammatory properties. The acute carrageenan induced paw edema in rats model was used and the tested compounds showed notable anti‐inflammatory potency without toxicity side effects.
Structural and Topological Study of Two Coordination Polymers Formed by 1,2,4,5 – Benzenetetracarboxylic Acid, Isonicotinylhydrazine and Metallic Ions Co2+ and Zn2+
Authors: de Almeida Filipe B. , Cunha Mariana S. , De Abreu Heitor A. , Diniz Renata 
Published: August 2016

AbstractIn this work it is highlighted the structural and topological study of two coordination polymers formed by 1,2,4,5–Benzenetetracarboxylic acid (H4BTC), Isonicotinylhydrazine (INH) and metallic ions Co2+ and Zn2+. Even formed by the same ligands, these coordination polymers are very different. The polymer formed by ligands and Co2+ (compound 1), forms as a 3D coordination polymer and it crystalline stability is due to its coordination bonds. On the other hand, the compound formed by ligands and Zn2+ (compound 2), forms a 1D coordination polymer and it is mainly stabilized by hydrogen bonds. Due to these facts, their structures present different and interesting topologies. Other interesting difference is related to coordination mode of H4BTC ligand. In compound 1, the H4BTC ligand is coordinated by carboxylate groups to cobalt ion by a monodentate way and by a bidentate bridge way. However, in compound 2 the H4BTC coordinates to zinc ion in a bidentate way by two different carboxylate groups. In both compounds the INH ligand coordinates in the same way to the metallic sites.
Solvent–free and Selective Autooxidation of Alkylbenzenes Catalyzed by Co/NHPI under Phase Transfer Conditions
Authors: Patil Rajendra D , Fuchs Batya , Taha Nimer , Sasson Yoel 
Published: August 2016

AbstractSolvent‐free, selective and sustainable reaction protocol for an autoxidation of alkylbenzenes catalyzed by Co‐NHPI (Cobalt‐N‐hydroxyphthalimide) under PTC (Phase Transfer Conditions) is described. A multigram scale preparation of acetophenone from ethylbenzene oxidation is demonstrated. The effect of catalyst [Cobalt, DDAB (Di‐n‐decyl‐di‐methyl ammonium bromide) and NHPI] concentrations, different types of catalysts, effect of temperature and oxygen pressure as well as reaction kinetics related to present auto‐oxidation of alkylbezenes is studied in details. Light microscope image shows that DDAB has Multi Lamellar Vesicles (MLVs) structures through which it protects NHPI at high temperatures. Thus efficient recovery and reuse of present ternary catalytic system (Co‐NHPI/DDAB) is feasible.
The necessity, logic, and forms of replication
Authors: Bettis Richard A. , Helfat Constance E. , Shaver J. Myles 
Published: August 2016

Research summary: A replication study assesses whether the results of a particular prior study can be reproduced, including in new contexts with different data. Replication studies are critical for building a cumulative body of research knowledge. This article discusses and provides a typology of different types of replications, compares replications with other approaches to cumulating knowledge, and provides guidelines toward producing high‐quality replication studies. The articles in this Special Issue provide examples of replication studies in strategic management.Managerial summary: Research studies sometimes draw implications for managerial practice. A single empirical study, however, is specific to a particular context, relies on a particular set of data, and uses a particular research design. As a consequence, a single study cannot establish whether the findings generalize to a different context and whether the research design is robust to alternative approaches. Replication studies can help to establish the range of applicability of prior studies and better support what implications can be drawn for managerial practice. Copyright © 2016 John Wiley & Sons, Ltd.
An extended release local anaesthetic: potential for future use in veterinary surgical patients?
Authors: Lascelles B. Duncan X. , Kirkby Shaw Kristin 
Published: August 2016

AbstractOne of the most effective means of preventing the transduction and transmission of acute and perioperative pain is through the use of local anaesthetics. However, local anaesthetics currently available have a relatively short duration of action. Although there are several tools available to treat perioperative pain in companion animals, overall, there is an unmet need for products that can be administered in the clinic, and provide pain relief for the crucial first few days following surgery in the home environment. Specifically, in relation to local anaesthetics, there is a clear unmet need for a long‐acting local anaesthetic that can be added to the multimodal analgesic protocol to provide pain relief to patients in the home environment or during extended hospitalization. Bupivacaine liposomal injectable suspension recently became available for use in humans, and has proven efficacious and safe. This paper will review the use of local anaesthetics, particularly bupivacaine, in dogs and cats, and introduce a new formulation of prolonged release bupivacaine that is in development for dogs and cats.