bluuebunny/crossref_metadata_2025_split huggingface dataset:
Universal BRCA1/BRCA2 Testing for Ovarian Cancer Patients is Welcomed, but with Care: How Women and Staff Contextualize Experiences of Expanded Access
Authors: Shipman Hannah , Flynn Samantha , MacDonald‐Smith Carey F , Brenton James , Crawford Robin , Tischkowitz Marc ,   on behalf of the GTEOC Study Group, Hulbert‐Williams Nicholas J 
Published: May 2017

AbstractDecreasing costs of genetic testing and advances in treatment for women with cancer with germline BRCA1/BRCA2 mutations have heralded more inclusive genetic testing programs. The Genetic Testing in Epithelial Ovarian Cancer (GTEOC) Study, investigates the feasibility and acceptability of offering genetic testing to all women recently diagnosed with epithelial ovarian cancer (universal genetic testing or UGT). Study participants and staff were interviewed to: (i) assess the impact of UGT (ii) integrate patients’ and staff perspectives in the development of new UGT programs. Semi‐structured interviews were conducted with twelve GTEOC Study participants and five members of staff involved in recruiting them. The transcripts were transcribed verbatim and analyzed using Interpretative Phenomenological Analysis. There are two super‐ordinate themes: motivations and influences around offers of genetic testing and impacts of genetic testing in ovarian cancer patients. A major finding is that genetic testing is contextualized within the broader experiences of the women; the impact of UGT was minimized in comparison with the ovarian cancer diagnosis. Women who consent to UGT are motivated by altruism and by their relatives’ influence, whilst those who decline are often considered overwhelmed or fearful. Those without a genetic mutation are usually reassured by this result, whilst those with a genetic mutation must negotiate new uncertainties and responsibilities towards their families. Our findings suggest that UGT in this context is generally acceptable to women. However, the period shortly after diagnosis is a sensitive time and some women are emotionally overburdened. UGT is considered a ‘family affair’ and staff must acknowledge this.
Change in depression across adolescence: The role of early anger socialization and child anger
Authors: O'Neal Colleen R. , Weston Lynsey C. , He Xin , Huang Keng‐Yen , Pine Daniel S. , Kamboukos Dimitra , Brotman Laurie Miller 
Published: May 2017

ABSTRACTThe purpose of this longitudinal study was to examine the relations of early socialization of anger with change in adolescent depression, and moderation by child anger. Using a sample of low‐income, ethnic minority children at familial risk for psychopathology in the United States (n = 92; ages 3–5; 53% female; 65% African American; 27% Latina/o), early anger socialization (i.e., parent response to child anger) was tested as a predictor of change in depression from preadolescence to adolescence [i.e., age 8 (n = 63), 11 (n = 58), and 13 (n = 44)]. A videotaped parent‐child interaction was coded for parental socialization of preschooler anger, and psychiatric interviews of depression were conducted three times across preadolescence and adolescence. Major depression diagnoses increased from preadolescence to adolescence. Latent growth modeling indicated parent discouragement of child anger was a significant predictor of an increase in the child's later depression from preadolescence to adolescence, and child anger intensity was a significant moderator.
Clinicopathological evaluation of Marjolin ulcers over two decades
Authors: Oruç Melike , Kankaya Yüksel , Sungur Nezih , Özer Kadri , Işık Veysel Murat , Ulusoy M. Gürhan , Uysal Afşin , Koçer Uğur 
Published: June 2017

AbstractMalignant changes arising on the previously traumatized or chronically inflamed skin are defined as Marjolin ulcers. They can develop on many different lesions but frequently they are detected on burn scars. Histopathologically, Marjolin ulcers are mostly diagnosed as squamous cell carcinoma and they need special attention when especially located on the lower extremities. In this study, 63 patients treated for Marjolin ulcers between January 2000 and March 2015 were evaluated according to etiology, histological differentiation, primary tumor size, patient age and anatomical localization. Medical records of these patients were reviewed retrospectively. Mean age was 49.7 years. Average interval between the first injury and carcinoma development was 37.9 years. Most frequent etiologic factor was burn scars with 82.5%. Foot was the most frequently affected site with 28.6% and scalp was the second most frequent localization with 25.4%. Squamous cell carcinomas were detected in 88.9% of the patients and basal cell carcinomas were detected in 11.1% of the patients. For treatment, excision and grafting was performed for 48 patients (76.2%), excision and local flaps were used for 10 patients (15.9%) and excision and free flaps were used for five patients (7.9%). Regional lymph node dissection was performed for 12 patients (19%). Average follow up period was 46.5 months. Local recurrences were detected in nine patients (14.3%). In conclusion, Marjolin ulcers are aggressive tumors that require special care. In order to prevent life threatening sequelas of this entity, it is important to know basic aspects of clinical progress, prognostic factors and treatment modalities.
Survey of Canadian Myotonic Dystrophy Patients’ Access to Computer Technology
Authors: Climans Seth A. , Piechowicz Christine , Koopman Wilma J. , Venance Shannon L. 
Published: May 2017

AbstractBackground: Myotonic dystrophy type 1 is an autosomal dominant condition affecting distal hand strength, energy, and cognition. Increasingly, patients and families are seeking information online. An online neuromuscular patient portal under development can help patients access resources and interact with each other regardless of location. It is unknown how individuals living with myotonic dystrophy interact with technology and whether barriers to access exist. We aimed to characterize technology use among participants with myotonic dystrophy and to determine whether there is interest in a patient portal. Methods: Surveys were mailed to 156 participants with myotonic dystrophy type 1 registered with the Canadian Neuromuscular Disease Registry. Results: Seventy-five participants (60% female) responded; almost half were younger than 46 years. Most (84%) used the internet; almost half of the responders (47%) used social media. The complexity and cost of technology were commonly cited reasons not to use technology. The majority of responders (76%) were interested in a myotonic dystrophy patient portal. Conclusions: Patients in a Canada-wide registry of myotonic dystrophy have access to and use technology such as computers and mobile phones. These patients expressed interest in a portal that would provide them with an opportunity to network with others with myotonic dystrophy and to access information about the disease.
Leadership and innovation: The moderator role of organization support for innovative behaviors
Authors: Mokhber Mozhdeh , Khairuzzaman Wan , Vakilbashi Amin 
Published: May 2017

AbstractThis study aims to advance the understanding of direct and moderated effect of transformational leadership on organizational innovation. A new framework is proposed in this research to identify the moderating effect of organization support for idea generating, risk taking and decision-making on the relationship between transformational leadership and organizational innovation. A sample of 63 companies from top 100 Iranian companies participated in this research. The results of this study supported the expected positive relationship between transformational leadership and organizational innovation. Besides, two of the predicted moderating effects were supported in this research. The results suggest that transformational leaders might not only promote innovative activity within the organization but also ensure the market success of the innovations.
Evaluation of anin vitrofibre fermentation method using feline faecal inocula: inter-individual variation
Authors: Bosch Guido , Heesen Lisa , de Melo Santos Karine , Cone John W. , Pellikaan Wilbert F. , Hendriks Wouter H. 
Published: May 2017

AbstractThe present study aimed to evaluate the inter-individual variability in fermentation of standard fibrous substrates by faecal inocula from ten healthy adult female cats. Substrates were citrus pectin (CP), fructo-oligosaccharides (FOS), guar gum (GG), sugar beet pulp (SBP) and wheat middlings (WM). Each substrate was incubated with faecal inoculum from each cat. Gas production was measured continuously during the 48 h incubation and SCFA and organic matter disappearance (only SBP and WM) after incubation. Out of ten cats, nine produced faeces on the days of inoculum preparation. The substrates contrasted in terms of fermentation parameters measured. The inter-individual variability was in general lower for the more simple and pure substrates (CP, FOS, GG) than for the more complex substrates containing mixtures of fibres (SBP, WM). Furthermore, for total SCFA and gas produced, inter-individual variability was lower than for proportions of butyrate and of branched-chain fatty acids and for the parameters of gas production kinetics. It is concluded that the variability inin vitrofermentation parameters is associated with the complexity of fibrous substrates. The presented data are instrumental for the calculation of number of faecal donors required for precisein vitrocharacterisation of the fermentability of dietary fibres. In addition, the number of faecal donors should be adjusted to the specific fermentation parameter(s) of interest.
Is improvement in the Healthy Food Intake Index (HFII) related to a lower risk for gestational diabetes?
Authors: Meinilä Jelena , Valkama Anita , Koivusalo Saila B. , Stach-Lempinen Beata , Rönö Kristiina , Lindström Jaana , Kautiainen Hannu , Eriksson Johan G. , Erkkola Maijaliisa 
Published: May 2017

AbstractThe aim was to analyse whether changes in the Healthy Food Intake Index (HFII) during pregnancy are related to gestational diabetes (GDM) risk. The 251 pregnant women participating had a pre-pregnancy BMI≥30 kg/m2 and/or a history of GDM. A 75 g oral glucose tolerance test (OGTT) was performed during the first and second trimesters of pregnancy for assessment of GDM. A normal OGTT result at first trimester was an inclusion criterion for the study. FFQ collected at first and second trimesters served for calculating the HFII. A higher HFII score reflects higher adherence to the Nordic Nutrition Recommendations (NNR) (score range 0–17). Statistical methods included Student’s t test, Mann–Whitney U test, Fisher’s exact test and linear and logistic regression analyses. The mean HFII at first trimester was 10·1 (95 % CI 9·7, 10·4) points, and the mean change from the first to the second trimester was 0·35 (95 % CI 0·09, 0·62) points. The range of the HFII changes varied from –7 to 7. The odds for GDM decreased with higher HFII change (adjusted OR 0·83 per one unit increase in HFII; 95 % CI 0·69, 0·99; P=0·043). In the analysis of the association between HFII-sub-indices and GDM, odds for GDM decreased with higher HFII-Fat change (fat percentage of milk and cheese, type of spread and cooking fats) but it was not significant in a fully adjusted model (P=0·058). Dietary changes towards the NNR during pregnancy seem to be related to a lower risk for GDM.
Wh-questions in child bilingual acquisition of French: Derivational complexity and cross-linguistic influence
Authors: Strik Nelleke 
Published: May 2017

AbstractThis study investigates the development ofwh-questions in French in a group of bilingual French-Dutch children. Fifteen children (aged 4 to 8, mean age 6;03, first exposure to French under age 4 for most of the children) participated in an elicited production task. Their results were compared to those of 4-year-old and 6-year-old monolingual children from a previous study. In order to examine possible influence from Dutch, two main hypotheses with contrasting predictions are proposed: structural overlap and derivational complexity. The results show that the bilingual children exhibited the same developmental course forwh-questions as their monolingual peers. The majority of responses involvedwh-fronting without inversion, whereaswh-fronting with inversion, the only possible structure in Dutch, was not frequent. Therefore, the results do not provide clear evidence for influence from Dutch. Instead, they confirm that derivational complexity constrains the development ofwh-questions in French.
The distribution of digenean metacercariae within bream (Abramis brama) gill apparatus: preferences, co-occurrence and interactions of parasites
Authors: Zolovs M. , Kanto J. , Jakubāne I. 
Published: May 2017

AbstractSpecies-specific microenvironmental preferences and interactions between parasite species have been the focus of many ecological studies. Here, we studied the distribution of ectoparasite species within the gill apparatus of bream (Abramis brama) from Lake Lubāns (Latvia) to establish whether digenean metacercariae: (1) prefer specific patches within the gill apparatus; (2) co-occur in the same patches with monogeneans and copepods within a host individual; and (3) interact with monogeneans and copepods. We recorded all parasites on gill arches of the same host species and used null models to analyse co-occurrences of digenean metacercariae, monogeneans and copepods. Zero-inflated mixture models were used to define the preferred patches of parasites. We found that digenean metacercariae (Bucephalus polymorphus) prefer specific patches of the gill apparatus to encyst, and shared these preferences with monogeneans and copepods, but did not interact with them. We concluded that digenean metacercariae have a species-specific microenvironmental preference to encyst in the gill apparatus and their occurrence (even in high numbers) does not reduce the success of attachment of monogeneans and copepods in the same gill patches.
Induction of resident memory T cells enhances the efficacy of cancer vaccine
Authors: Nizard Mevyn , Roussel Hélène , Diniz Mariana O. , Karaki Soumaya , Tran Thi , Voron Thibault , Dransart Estelle , Sandoval Federico , Riquet Marc , Rance Bastien , Marcheteau Elie , Fabre Elizabeth , Mandavit Marion , Terme Magali , Blanc Charlotte , Escudie Jean-Baptiste , Gibault Laure , Barthes Françoise Le Pimpec , Granier Clemence , Ferreira Luis C. S. , Badoual Cecile , Johannes Ludger , Tartour Eric 
Published: May 2017

AbstractTissue-resident memory T cells (Trm) represent a new subset of long-lived memory T cells that remain in tissue and do not recirculate. Although they are considered as early immune effectors in infectious diseases, their role in cancer immunosurveillance remains unknown. In a preclinical model of head and neck cancer, we show that intranasal vaccination with a mucosal vector, the B subunit of Shiga toxin, induces local Trm and inhibits tumour growth. As Trm do not recirculate, we demonstrate their crucial role in the efficacy of cancer vaccine with parabiosis experiments. Blockade of TFGβ decreases the induction of Trm after mucosal vaccine immunization, resulting in the lower efficacy of cancer vaccine. In order to extrapolate this role of Trm in humans, we show that the number of Trm correlates with a better overall survival in lung cancer in multivariate analysis. The induction of Trm may represent a new surrogate biomarker for the efficacy of cancer vaccine. This study also argues for the development of vaccine strategies designed to elicit them.
Magnetic-field induced multiple topological phases in pyrochlore iridates with Mott criticality
Authors: Ueda Kentaro , Oh Taekoo , Yang Bohm-Jung , Kaneko Ryoma , Fujioka Jun , Nagaosa Naoto , Tokura Yoshinori 
Published: May 2017

AbstractThe interplay between electron correlation and spin–orbit coupling in solids has been proven to be an abundant gold mine for emergent topological phases. Here we report the results of systematic magnetotransport study on bandwidth-controlled pyrochlore iridates R2Ir2O7 near quantum metal-insulator transition (MIT). The application of a magnetic field along [001] crystallographic direction (H//[001]) significantly decreases resistivity while producing a unique Hall response, which indicates the emergence of the novel semi-metallic state in the course of the magnetic transformation from all-in all-out (AIAO, 4/0) to 2-in 2-out (2/2) spin configuration. For H//[111] that favours 3-in 1-out (3/1) configuration, by contrast, the resistivity exhibits saturation at a relatively high value typical of a semimetal. The observed properties can be identified to reflect the emergence of multiple Weyl semimetal states with varying numbers of Weyl points and line nodes in respective spin configurations. With tuning effective bandwidth, all these states appear to concentrate around the quantum MIT region, which may open a promising venue for topological phenomena and functions.
A synthetic biochemistry platform for cell free production of monoterpenes from glucose
Authors: Korman Tyler P. , Opgenorth Paul H. , Bowie James U. 
Published: May 2017

AbstractCell-free systems designed to perform complex chemical conversions of biomass to biofuels or commodity chemicals are emerging as promising alternatives to the metabolic engineering of living cells. Here we design a system comprises 27 enzymes for the conversion of glucose into monoterpenes that generates both NAD(P)H and ATP in a modified glucose breakdown module and utilizes both cofactors for building terpenes. Different monoterpenes are produced in our system by changing the terpene synthase enzyme. The system is stable for the production of limonene, pinene and sabinene, and can operate continuously for at least 5 days from a single addition of glucose. We obtain conversion yields >95% and titres >15 g l−1. The titres are an order of magnitude over cellular toxicity limits and thus difficult to achieve using cell-based systems. Overall, these results highlight the potential of synthetic biochemistry approaches for producing bio-based chemicals.
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism
Authors: Sapkota Yadav , Steinthorsdottir Valgerdur , Morris Andrew P. , Fassbender Amelie , Rahmioglu Nilufer , De Vivo Immaculata , Buring Julie E. , Zhang Futao , Edwards Todd L. , Jones Sarah , O Dorien , Peterse Daniëlle , Rexrode Kathryn M. , Ridker Paul M. , Schork Andrew J. , MacGregor Stuart , Martin Nicholas G. , Becker Christian M. , Adachi Sosuke , Yoshihara Kosuke , Enomoto Takayuki , Takahashi Atsushi , Kamatani Yoichiro , Matsuda Koichi , Kubo Michiaki , Thorleifsson Gudmar , Geirsson Reynir T. , Thorsteinsdottir Unnur , Wallace Leanne M. ,   iPSYCH-SSI-Broad Group, Werge Thomas M. , Thompson Wesley K. , Yang Jian , Velez Edwards Digna R. , Nyegaard Mette , Low Siew-Kee , Zondervan Krina T. , Missmer Stacey A. , D'Hooghe Thomas , Montgomery Grant W. , Chasman Daniel I. , Stefansson Kari , Tung Joyce Y. , Nyholt Dale R. 
Published: May 2017

AbstractEndometriosis is a heritable hormone-dependent gynecological disorder, associated with severe pelvic pain and reduced fertility; however, its molecular mechanisms remain largely unknown. Here we perform a meta-analysis of 11 genome-wide association case-control data sets, totalling 17,045 endometriosis cases and 191,596 controls. In addition to replicating previously reported loci, we identify five novel loci significantly associated with endometriosis risk (P<5 × 10−8), implicating genes involved in sex steroid hormone pathways (FN1, CCDC170, ESR1, SYNE1 and FSHB). Conditional analysis identified five secondary association signals, including two at the ESR1 locus, resulting in 19 independent single nucleotide polymorphisms (SNPs) robustly associated with endometriosis, which together explain up to 5.19% of variance in endometriosis. These results highlight novel variants in or near specific genes with important roles in sex steroid hormone signalling and function, and offer unique opportunities for more targeted functional research efforts.
The interfacial structure of water droplets in a hydrophobic liquid
Authors: Smolentsev Nikolay , Smit Wilbert J. , Bakker Huib J. , Roke Sylvie 
Published: May 2017

AbstractNanoscopic and microscopic water droplets and ice crystals embedded in liquid hydrophobic surroundings are key components of aerosols, rocks, oil fields and the human body. The chemical properties of such droplets critically depend on the interfacial structure of the water droplet. Here we report the surface structure of 200 nm-sized water droplets in mixtures of hydrophobic oils and surfactants as obtained from vibrational sum frequency scattering measurements. The interface of a water droplet shows significantly stronger hydrogen bonds than the air/water or hexane/water interface and previously reported planar liquid hydrophobic/water interfaces at room temperature. The observed spectral difference is similar to that of a planar air/water surface at a temperature that is ∼50 K lower. Supercooling the droplets to 263 K does not change the surface structure. Below the homogeneous ice nucleation temperature, a single vibrational mode is present with a similar mean hydrogen-bond strength as for a planar ice/air interface.
The mobility of small vacancy/helium complexes in tungsten and its impact on retention in fusion-relevant conditions
Authors: Perez Danny , Sandoval Luis , Blondel Sophie , Wirth Brian D. , Uberuaga Blas P. , Voter Arthur F. 
Published: May 2017

AbstractTungsten is a promising plasma facing material for fusion reactors. Despite many favorable properties, helium ions incoming from the plasma are known to dramatically affect the microstructure of tungsten, leading to bubble growth, blistering, and/or to the formation of fuzz. In order to develop mitigation strategies, it is essential to understand the atomistic processes that lead to bubble formation and subsequent microstructural changes. In this work, we use large-scale Accelerated Molecular Dynamics simulations to investigate small (N = 1,2) V
N
He
M
vacancy/helium complexes, which serve as the nuclei for larger helium bubble growth, over timescales reaching into the milliseconds under conditions typical of the operation of fusion reactors. These complexes can interconvert between different I
L
V
N+L
He
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variants via Frenkel pair nucleation (leading to the creation of a additional vacancy/interstitial pair) and annihilation events; sequences of these events can lead to net migration of these embryonic bubbles. The competition between nucleation and annihilation produces a very complex dependence of the diffusivity on the number of heliums. Finally, through cluster dynamics simulations, we show that diffusion of these complexes provides an efficient pathway for helium release at fluxes expected in fusion reactors, and hence that accounting for the mobility of these complexes is crucial.