bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acceleration toward polarization singularity inspired by relativistic E×B drift
Authors: Yu Sunkyu , Piao Xianji , Park Namkyoo 
Published: November 2016

AbstractThe relativistic trajectory of a charged particle driven by the Lorentz force is different from the classical one, by velocity-dependent relativistic acceleration term. Here we show that the evolution of optical polarization states near the polarization singularity can be described in analogy to the relativistic dynamics of charged particles. A phase transition in parity-time symmetric potentials is then interpreted in terms of the competition between electric and magnetic ‘pseudo’-fields applied to polarization states. Based on this Lorentz pseudo-force representation, we reveal that zero Lorentz pseudo-force is the origin of recently reported strong polarization convergence to the singular state at the exceptional point. We also demonstrate the deterministic design of achiral and directional eigenstates at the exceptional point, allowing an anomalous linear polarizer which operates orthogonal to forward and backward waves. Our results linking parity-time symmetry and relativistic electrodynamics show that previous PT-symmetric potentials for the polarization singularity with a chiral eigenstate are the subset of optical potentials for the E×B “polarization” drift.
Mint3/Apba3 depletion ameliorates severe murine influenza pneumonia and macrophage cytokine production in response to the influenza virus
Authors: Uematsu Takayuki , Fujita Tomoko , Nakaoka Hiroki J. , Hara Toshiro , Kobayashi Noritada , Murakami Yoshinori , Seiki Motoharu , Sakamoto Takeharu 
Published: November 2016

AbstractInfluenza virus (IFV) infection is a common cause of severe pneumonia. Studies have suggested that excessive activation of the host immune system including macrophages is responsible for the severe pathologies mediated by IFV infection. Here, we focused on the X11 protein family member Mint3/Apba3, known to promote ATP production via glycolysis by activating hypoxia inducible factor-1 (HIF-1) in macrophages, and examined its roles in lung pathogenesis and anti-viral defence upon IFV infection. Mint3-deficient mice exhibited improved influenza pneumonia with reduced inflammatory cytokines/chemokine levels and neutrophil infiltration in the IFV-infected lungs without alteration in viral burden, type-I interferon production, or acquired immunity. In macrophages, Mint3 depletion attenuated NF-κB signalling and the resultant cytokine/chemokine production in response to IFV infection by increasing IκBα and activating the cellular energy sensor AMPK, respectively. Thus, Mint3 might represent one of the likely therapeutic targets for the treatment of severe influenza pneumonia without affecting host anti-viral defence through suppressing macrophage cytokine/chemokine production.
Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways
Authors: Zhao Yong , Zhang Wei-Dong , Liu Xin-Qi , Zhang Peng-Fei , Hao Ya-Nan , Li Lan , Chen Liang , Shen Wei , Tang Xiang-Fang , Min Ling-Jiang , Meng Qing-Shi , Wang Shu-Kun , Yi Bao , Zhang Hong-Fu 
Published: November 2016

AbstractA number of emerging studies suggest that air pollutants such as hydrogen sulfide (H2S) and ammonia (NH3) may cause a decline in spermatozoa motility. The impact and underlying mechanisms are currently unknown. Boar spermatozoa (in vitro) and peripubertal male mice (in vivo) were exposed to H2S and/or NH3 to evaluate the impact on spermatozoa motility. Na2S and/or NH4Cl reduced the motility of boar spermatozoa in vitro. Na2S and/or NH4Cl disrupted multiple signaling pathways including decreasing Na+/K+ ATPase activity and protein kinase B (AKT) levels, activating Adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK) and phosphatase and tensin homolog deleted on chromosome ten (PTEN), and increasing reactive oxygen species (ROS) to diminish boar spermatozoa motility. The increase in ROS might have activated PTEN, which in turn diminished AKT activation. The ATP deficiency (indicated by reduction in Na+/K+ ATPase activity), transforming growth factor (TGFβ) activated kinase-1 (TAK1) activation, and AKT deactivation stimulated AMPK, which caused a decline in boar spermatozoa motility. Simultaneously, the deactivation of AKT might play some role in the reduction of boar spermatozoa motility. Furthermore, Na2S and/or NH4Cl declined the motility of mouse spermatozoa without affecting mouse body weight gain in vivo. Findings of the present study suggest that H2S and/or NH3 are adversely associated with spermatozoa motility.
TGF beta receptor II interacting protein-1, an intracellular protein has an extracellular role as a modulator of matrix mineralization
Authors: Ramachandran Amsaveni , Ravindran Sriram , Huang Chun-Chieh , George Anne 
Published: November 2016

AbstractTransforming growth factor beta receptor II interacting protein 1 (TRIP-1), a predominantly intracellular protein is localized in the ECM of bone. TRIP-1 lacks a signal peptide, therefore, in this study, we provide evidence that intracellular TRIP-1 can be packaged and exported to the ECM via exosomes. Overexpression of TRIP-1 in MC3T3-E1 cells resulted in increased matrix mineralization during differentiation and knockdown resulted in reduced effects. In vivo function of TRIP-1 was studied by an implantation assay performed using TRIP-1 overexpressing and knockdown cells cultured in a 3-dimmensional scaffold. After 4 weeks, the subcutaneous tissues from TRIP-1 overexpressing cells showed higher calcium and phosphate deposits, arranged collagen fibrils and increased expression of Runx2 and alkaline phosphatase. Nucleation studies on demineralized and deproteinized dentin wafer is a powerful tool to determine the functional role of noncollagenous proteins in matrix mineralization. Using this system, we provide evidence that TRIP-1 binds to Type-I collagen and can promote mineralization. Surface plasmon resonance analysis demonstrated that TRIP-1 binds to collagen with KD = 48 μM. SEM and TEM analysis showed that TRIP-1 promoted the nucleation and growth of calcium phosphate mineral aggregates. Taken together, we provide mechanistic insights of this intracellular protein in matrix mineralization.
All-optical THz wave switching based on CH3NH3PbI3 perovskites
Authors: Lee Kyu-Sup , Kang Rira , Son Byungwoo , Kim Dong-Yu , Yu Nan Ei , Ko Do-Kyeong 
Published: November 2016

AbstractHybrid structures of silicon with organic–inorganic perovskites are proposed for optically controllable switching of terahertz (THz) waves over a broad spectral range from 0.2 to 2THz. A 532-nm external laser was utilized to generate photoexcited free carriers at the devices and consequentially to control the terahertz amplitude modulation, obtaining a depth of up to 68% at a laser irradiance of 1.5 W/cm2. In addition, we compared the performances from three types of perovskite devices fabricated via different solution processing methods and suggested a stable and highly efficient THz switch based on a one-step processing. By this we demonstrated the possibility of perovskites as THz wave switching devices in addition to photovoltaics.
Impaired Endothelial Nitric Oxide Synthase Homodimer Formation Triggers Development of Transplant Vasculopathy - Insights from a Murine Aortic Transplantation Model
Authors: Oberhuber Rupert , Riede Gregor , Cardini Benno , Bernhard David , Messner Barbara , Watschinger Katrin , Steger Christina , Brandacher Gerald , Pratschke Johann , Golderer Georg , Werner Ernst R. , Maglione Manuel 
Published: November 2016

AbstractTransplant vasculopathy (TV) represents a major obstacle to long-term graft survival and correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric oxide synthases (NOS) co-factor tetrahydrobiopterin has been shown to prevent IRI. Herein, we analysed whether tetrahydrobiopterin is also involved in TV development. Using a fully allogeneic mismatched (BALB/c to C57BL/6) murine aortic transplantation model grafts subjected to long cold ischemia time developed severe TV with intimal hyperplasia (α-smooth muscle actin positive cells in the neointima) and endothelial activation (increased P-selectin expression). Donor pretreatment with tetrahydrobiopterin significantly minimised these changes resulting in only marginal TV development. Severe TV observed in the non-treated group was associated with increased protein oxidation and increased occurrence of endothelial NOS monomers in the aortic grafts already during graft procurement. Tetrahydrobiopterin supplementation of the donor prevented all these early oxidative changes in the graft. Non-treated allogeneic grafts without cold ischemia time and syngeneic grafts did not develop any TV. We identified early protein oxidation and impaired endothelial NOS homodimer formation as plausible mechanistic explanation for the crucial role of IRI in triggering TV in transplanted aortic grafts. Therefore, targeting endothelial NOS in the donor represents a promising strategy to minimise TV.
Stability of the interstellar hydrogen inflow longitude from 20 years of SOHO/SWAN observations
Authors: Koutroumpa D. , Quémerais E. , Katushkina O. , Lallement R. , Bertaux J.-L. , Schmidt W. 
Published: November 2016

Aims. A recent debate on the decade-long stability of the interstellar He flow vector, and in particular the flow longitude, has prompted us to check for any variability in the interstellar H flow vector as observed by the SWAN instrument on board SOHO.
Methods. We used a simple model-independent method to determine the interstellar H flow longitude, based on the parallax effects induced on the Lyman-α intensity measured by SWAN following the satellite motion around the Sun.
Results. Our results show that the interstellar H flow vector longitude does not vary significantly from an average value of 252.9°± 1.4° throughout the 20-year span of the SWAN dataset, further strengthening the arguments for the stability of the interstellar gas flow.
Mesencephalotomy, How I Do It: Analysis of 34 Cases
Authors: Lages Gustavo Veloso , Oliveira Júnior José Oswaldo 
Published: November 2016

AbstractThe present paper aims to demystify the use of rostral mesencephalic reticulotomy (mesencephalotomy) in the treatment of chronic pain in cancer patients. A retrospective review of the medical records from the Central Pain and Stereotaxy Department of the A. C. Camargo Cancer Center, São Paulo, state of São Paulo, Brazil, between 2005 and 2012, was performed. Surgical indication was restricted to patients with cancer pain refractory to etiological and symptomatic treatments, > 2 months of expected survival, preserved cognition, and absence of coagulation disorders, of systemic infection, and of intracranial hypertension. We have selected 34 patients, with an average follow-up of 9.4 months, an average age of 54.3 years-old, and an average follow-up time until death of 6.4 months. Lung cancer was the most frequent diagnosis. Satisfactory and immediate pain relief was achieved in 91% of the cases, and 83% of these patients had no relapses. Among the complications, ocular movement disorder was the most frequent, but often transient. Permanent disturbances occurred in 8.8% of the cases (diplopia, rubral tremor, and paresthesia). Compared to the pharmacological treatment, mesencephalotomy was economically feasible, more effective, and improved quality of life. According to the data presented, it can be concluded that mesencephalotomy is a viable procedure for cancer pain control in selected cases.
A functional role for intrinsic disorder in the tau-tubulin complex
Authors: Melo Ana M. , Coraor Juliana , Alpha-Cobb Garrett , Elbaum-Garfinkle Shana , Nath Abhinav , Rhoades Elizabeth 
Published: November 2016

Significance
Tau is a neuronal microtubule-associated protein linked to numerous neurodegenerative disorders, including Alzheimer’s disease. Several lines of evidence support tau aggregation as well as loss of its native interactions with microtubules as contributing to pathology. Here, we explored the largely overlooked first step of microtubule assembly, namely the interaction of tau with soluble tubulin heterodimers. Using single-molecule Förster Resonance Energy Transfer (smFRET), we determine the topological features of tau in complex with tubulin. Our results contrast differences in tau isoforms and underscore the importance of conformational flexibility in tau function.
Comparative proteomics analysis of spermary and ovary in Hyriopsis schlegelii
Authors: Shi Jianwu , Wang Dexia , Zhou Yan , Gu Yiran , Wu Di , Wang Junhua , Hong Yijiang 
Published: November 2016

Abstract
We provide the first large-scale quantitative proteomics analysis in Hyriopsis schlegelii. To investigate the proteins expressed in the gonads, a quantitative proteomics approach has been utilized to analyze differentially expressed proteins between the spermary and ovary. In this study, we identified and quantified 2416 proteins in the gonads of Hyriopsis schlegelii. Of these, 559 proteins showed significantly different expression between the spermary and ovary. Some specific proteins expressed in either the spermary or ovary were identified in Hyriopsis schlegelii. In addition, a series of proteins related to gametogenesis were also identified. Compared with previous reports, many proteins in Hyriopsis schlegelii identified here have different expression patterns between the spermary and ovary. The special hermaphroditism in Hyriopsis schlegelii may contribute to these inconsistent results. The provided proteomics data could be considered as a starting point for subsequent studies focusing on the proteins involved in sexual gland development and maturity.
Concepts of Epidemiology
Authors: Bhopal Raj S. 
Published: November 2016

Abstract
Epidemiology is a population science that underpins health improvement and health care, and is concerned with the pattern, frequency, trends, and causes of disease. This book teaches its applications to population health research, policy-making, health service planning, health promotion, and clinical care. The book emphasizes concepts and principles. In 10 chapters, the book explains what epidemiology is; illustrates the basis of epidemiology in populations; provides a framework for analysing diseases by time, place, and person; introduces error, bias, and confounding; explains how we move from association to causation; considers the natural history, spectrum, and iceberg of disease in relation to medical screening; discusses the acquisition and analysis of data on incidence and prevalence of risk factors and diseases; shows the ways in which epidemiological data are presented, including relative and absolute risks; provides an integrated overview of study designs and the principles of data analysis; and considers the theoretical and ethical basis of epidemiology both in the past and the future. The emphasis is on interactive learning, with each chapter including learning objectives, theoretical and numerical exercises, questions and answers, and a summary. The text is illustrated, with detailed material in tables. The book is written in plain English, and the necessary technical and specialized terminology is explained and defined in a glossary. The book is for postgraduate courses in epidemiology, public health, and health policy. It is also suitable for clinicians, undergraduate students in medicine, nursing and other health disciplines, and researchers.
A novel subsartorial approach in open reduction of developmental dysplasia of the hip: a preliminary 2-year follow-up report of 20 hips
Authors: Samir Barakat Mostafa Ahmed , Zein Abou Bakr , El Sayed Mohamed Fouad , Reda Walid , Abdel Karim Mahmoud , Amr Sherif , Elbarbary Hassan , Hegazy Mohamed 
Published: November 2016

Background:
The anterior (Smith-Peterson) and medial (Ludloff) procedures are the most common approaches used for subluxation or dislocation in developmental dysplasia of the hip that cannot be treated conservatively. If conservative treatment has failed, additional procedures on the pelvic or femoral side may become necessary.

Methods:
In this prospective study we used a new subsartorial approach in the surgical treatment of 20 hips (17 patients of whom three had bilateral hip dysplasia) with a mean follow-up of 23.9 mo (range 22-26 mo). There were 16 hips in 13 girls and four unilateral hips in four boys. At surgery, the ages ranged from 9 to 24 mo, with a mean of 16.5 mo. The degree of initial hip subluxation was graded according to the Tönnis classification, with two hips (10%) type II, eight hips (40%) type III, and 10 hips (50%) type IV. We evaluated the clinical and radiographic outcomes of the patient cohort with the McKay and Severin classifications, respectively.

Results:
Clinically there were 15 hips (75%) with an excellent results and five hips with good results. According to the radiographic Severin classification, nine hips had an excellent result (type I), 10 had a good result (type II), and one hip had a fair result (type III). One hip (5%) developed avascular necrosis according to the Kalmachi and MacEwan classification but eventually had good clinical outcome precluding any surgical intervention. Two girls (10%) developed left lateral subluxation 3 mo postoperatively. Femoral derotation osteotomy was done 6 mo postoperatively.

Conclusions:
The subsartorial approach was a safe, reliable, and reproducible approach in the pediatric hip in patients younger than 2 yr of age who had not had a previous operation or a history of paralytic hip dislocation. We recommend this approach for surgeons who are familiar with the pediatric hip.
The Association Between Out-of-Pocket Costs and Adherence to Adjuvant Endocrine Therapy Among Newly Diagnosed Breast Cancer Patients
Authors: Farias Albert J. , Hansen Ryan N. , Zeliadt Steven B. , Ornelas India J. , Li Christopher I. , Thompson Beti 
Published: November 2016

Objective:
To determine how out-of-pocket costs for adjuvant endocrine therapy (AET) medication affects adherence among newly diagnosed breast cancer survivors with private health insurance who initiate therapy.

Materials and Methods:
We examined medical and pharmacy claims for the 1-year period after initiating AET using the Truven Health Analytics MarketScan database. Adherence was defined as ≥80% proportion of days covered. Mean out-of-pocket costs for AET fill were measured as the sum of copayments, coinsurance, and deductibles and adjusted to 30-day amounts. Using a multivariable logistic regression model we calculated adjusted risk ratios controlling for age, comorbidities, type of surgery, use of chemotherapy and/or radiation therapy, average out-of-pocket costs for other services, and pharmacy use characteristics.

Results:
Of the 6863 women 64 years and younger who were diagnosed with breast cancer and initiated AET, 73.9% were adherent (proportion of days covered≥80%). A total of 19% of patients had <$5 monthly out-of-pocket costs for AET, 30% had $5 to $9.99, 17% had $10 to $14.99, 10% had $15 to $19.99, and 25% had $20 or greater. Patients with out-of-pocket costs for AET between $10 and $14.99, $15 and $19.99, and >$20 were 6% to 8% less likely to be adherent compared with patients paying <$5.00, after controlling for covariates (P<0.05). Out-of-pocket costs for inpatient, outpatient, and other pharmacy services were not associated with adherence.

Conclusions:
A substantial proportion of privately insured patients are nonadherent to AET and out-of-pocket costs for AET medication are significantly associated with a greater likelihood of nonadherence.
Use of Platelet-rich Plasma for Vulvovaginal Autoimmune Conditions Like Lichen Sclerosus
Authors: Behnia-Willison Fariba , Pour Nina Reza , Mohamadi Behrang , Willison Nadia , Rock Madeleine , Holten Ian W. , O’Shea Robert , Miller Joseph 
Published: November 2016

Background:
Lichen sclerosus (LS) is an inflammatory dermatosis with autoimmune pathogenesis. Although relatively common, its true incidence is unknown and likely underestimated. LS is usually anogenital, but in around 10% of patients, it can present as extragenital lesions. Continuous administration of topical corticosteroids is the mainstay of medical treatment. Other treatments are available but are only occasionally prescribed along with or instead of topical steroids. Injection of platelet-rich plasma (PRP) into affected areas has been reported to result in the regeneration of normal skin. In this study, we aimed to evaluate the safety, symptom resolution, and objective improvement in patients with autoimmune condition like genital LS after treatment with PRP.

Methods:
Over a 2-year period at FBW Gynaecology Plus, we had a total of 28 patients with confirmed LS on biopsy, unresponsive to topical steroid treatment. After acquiring informed consent, patients’ own blood was centrifuged on site and injected under local anesthesia to the external genitalia.

Results:
Almost all of our patients showed clinical improvement in the size of their lesions, and in 8 cases, lesions totally disappeared after treatment with PRP. Symptoms disappeared in 15 of the 28 patients after treatment, with no need for further steroid therapy in 23 patients. Thirteen women experienced partial symptom relief.

Conclusions:
Based on our limited findings, we hypothesize that PRP presents a potential alternative to topical steroids for treatment of vulvovaginal autoimmune conditions such as LS. A larger pilot and/or randomized controlled trial study is required to evaluate this finding further.
Median Nerve Trifurcation
Authors: Lonie Sarah , Niumsawatt Vachara , Rozen Warren M. 
Published: November 2016

Summary:
Median nerve trifurcation in the carpal tunnel has only rarely been described and never reported to be found at surgery. We present the first such case, highlighting a median nerve trifurcation found at carpal tunnel release. Consideration of amendment of the Lanz classification should be made to account for such cases, and surgeons should be aware of possible anatomical variations to avoid iatrogenic injury.
Flexor Tendon Repair Postoperative Rehabilitation: The Saint John Protocol
Authors: Higgins Amanda , Lalonde Donald H. 
Published: November 2016

Summary:
The Saint John Protocol describes a rehabilitation program of up to half a fist of protected true active finger flexion beginning 3 to 5 days after flexor tendon repair. We no longer use full fist place and hold. We illustrate with film and text the reasons for these changes.