bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hsa_circ_0002473 inhibits GH3 cell proliferation and GH secretion as a competitive endogenous RNA for has-miR-4645-3p
Authors: Pan Kaiyu , Jiang Xiaoguang , Hu Xiaohong , Zhan Jianhua , Zhang Chengyue 
Published: October 2024

Abstract
Growth hormone deficiency (GHD) diagnosis still lacks a gold standard or ideal diagnostic marker. Unlike other epigenetic mechanisms, non-coding RNAs regulate post-transcriptional levels. The information on non-coding RNAs in the field of GHD is limited. Therefore, this study aimed to explore the role of hsa_circ_0002473 as a competitive endogenous RNA for has-miR-4645-3p in attenuating the inhibitory effect of has-miR-4645-3p on SSTR2. In this study, we screened three significantly expressed circular RNAs (circRNAs) in five children with GHD, and selected the highest expressed hsa_circ_0002473 as the study object, and screened has-miR-4645-3p, which is the most likely to bind to hsa_circ_0002473, according to the microRNA (miRNA)-circRNA regulatory network, to study the role and mechanism of has-miR-4645-3p as a competitive endogenous RNA of has-miR-4645-3p on GH3 cells. Somatostatin receptor 2 (SSTR2) inhibits GH3 cell proliferation, and miRNA binding to SSTR2 inhibits the latter expression. Both bioinformatics and dual-luciferase reporter analyses showed targeting relationships between hsa_circ_0002473 and has-miR-4645-3p and between has-miR-4645-3p and SSTR2. We constructed the hsa_circ_0002473/has-miR-4645-3p axis and transfected it into GH3 cells and found that overexpression of hsa_circ_0002473 inhibited the proliferation and growth hormone (GH) secretion of GH3 cells, and that hsa-miR-4645-3p promoted the proliferation and GH secretion of GH3 cells by targeting SSTR2. Co-culture revealed that the inhibitory effect of hsa_circ_0002473 was reversed by has-miR-4645-3p. In conclusion, our findings suggest that hsa_circ_0002473 can act as a competitive endogenous RNA for has-miR-4645-3p to regulate GH3 cell proliferation and secretion by targeting SSTR2.
Characterization of bauxite residue filled sisal/glass fiber reinforced hybrid composites for structural applications
Authors: Rasu Karthick , Veerabathiran Anbumalar 
Published: October 2024

Abstract
Composite materials with high compressive, flexural, and shear strength are essential for constructing various structural elements in automotive, aerospace, marine, and construction sectors. The present research aims to create bauxite residue filled sisal/glass fiber reinforced polyester composites. The different weight percentages of sisal fiber (35 %, 30 %, 25 %, and 20 %), red mud (0 %, 5 %, 10 %, and 15 %), glass fiber (5 %), and polyester matrix (60 %) were used to fabricate composites. The combined use of compression molding and hand layup technique was employed in the creation of composite materials due to its frequent utilization in the manufacturing of large-scale components found in various sectors, including automotive, aerospace, marine, and construction. In this work, investigated the physical, compressive, flexural and v notch rail shear strength of the fabricated composites. Results revealed that the composites with 30 % of sisal fiber and 5 % of red mud has the highest compressive, flexural, and v notch rail shear strength of 83.45 MPa, 182.74 MPa, and 10 MPa, respectively. Further, this composite showed high density, less void content, and less thickness swelling than other composites. According to the outcomes, this composite material demonstrates suitability for various structural applications across automotive, aerospace, marine, and construction sectors.
Development of zeolite 5A-incorporated polyvinyl alcohol membrane for desalination by pervaporation
Authors: Tirnakci Berk , Salt Yavuz 
Published: October 2024

Abstract
With the rapid depletion of potable and useable water resources globally due to population growth and the effects of global warming, the desalination of seawater – the world’s largest source of water – to acceptable quality levels is critical to meeting future water needs. This study investigates the use of zeolite 5A-incorporated polyvinyl alcohol membranes to produce fresh water from seawater for industrial and domestic use and evaluates the application of the pervaporation process on the separation performance. Polyvinyl alcohol and polyvinyl alcohol/zeolite 5A mixed matrix membranes were prepared by solution-casting technique, and their morphological, structural, and mechanical properties were analyzed by field emission scanning electron microscopy, thermogravimetric analysis, Fourier transform infrared spectroscopy, and tensile strength tests. The swelling behavior and pervaporation performance of the membranes were investigated at different temperatures (30, 45, and 60 °C) using synthetic seawater containing 35 g L−1 NaCl, and membrane–solvent interactions were determined using data from sorption experiments. The membrane produced water flux and salt rejection values at 60 °C of 5.82 kg m−2 h−1 and >99.9 %, respectively.
Molecularly imprinted polymer for the selective removal of direct violet 51 from wastewater: synthesis, characterization, and environmental applications
Authors: Khan Maaz , Ahmad Ilyas , Khan Shahab , Zeb Alam , Elsadek Mohamed F. , Patel Sanjaykumar , Al-Numair Khalid S. , Kulshreshta Ankur , Rahman Hameed U. 
Published: October 2024

Abstract
Molecularly imprinted polymers (MIPs) are a diverse class of materials designed for selective molecular recognition. These polymers are synthesized with particular binding sites that are suited to a target molecule or a collection of structurally similar molecules through the use of a process called molecular imprinting. MIPs were synthesized in this work to specifically remove direct violet 51 from occupational leachates and aqueous solutions. Methacrylic acid functioned as the functional monomer, ethylene glycol dimethacrylate (EGDMA) as the cross-linker, 2,2-azobisisobutyronitrile (AIBN) as the initiator, and alcohol as a porogenic solvent. To improve the dye removal effectiveness, a number of factors were optimized, including time, pH, analyte concentrations, and MIP/NIP dosages. The findings showed that MIPs had a much greater capacity for direct violet 51 adsorption than nonimprinted polymers (NIPs), with MIP adsorption capacity reaching 42.553 mg g−1 and NIP adsorption capacity reaching 7 mg g−1. The pseudo 2nd-order model described the adsorption kinetics, and the rate constant (K
2) for MIPs was found to be 0.00251 mg g−1 min. Furthermore, a high rebinding efficiency of 94 % was observed when the selectivity of MIPs for direct violet 51 was assessed against structurally similar templates.
Fair Games—Curating New Music
Authors: Moore Thomas R. , Gielen Pascal , Diependaele Rebecca 
Published: October 2024

The authors of “Defragmentation: Curating Contemporary Music,” a special issue of the Darmstädter Beiträge zur Neuen Musik published in 2019, considered all aspects of any given artistic event as fair game for curation. They suggested that not only could the choice of pieces, soloists, conductors, and ensembles be (re)tooled (including even site-specific aspects), but the roles of the musicians and audience and even value regimes could be instrumentalized to accord with the artistic demands of the curator. In her introduction to the special issue, Dorothee Richter argued that curation should be a “practice that is deeply involved in the politics of display, politics of site, politics of transfer and translation, and regimes of visibility.” If we understand politics with Jacques Rancière as “giving form to the social,” then Richter suggests that every thinkable manner in which people relate can, and should, be weighed when programming a concert. Curators need to reflect and act upon the way relationships in our world are displayed, the interplay involved on site, the participation or lack thereof of an audience, the participants’ ability to understand, enjoy, and be entertained, and even the audience’s and presenter’s perceived positions in society and how they play out in concert.
Writing as a performer-researcher, a cultural-sociologist, and a musicologist, and drawing on previous research in the visual arts, we discuss the impact of the curator within the European new music world. We question the curator’s central role and probe shifts in power relations between festival directors, receptive venues, and performing ensembles. In our view, the rise of the curator in the new music world leads us in at least two distinct directions. First, as in the visual arts world, the individual curator may assume the role of the new protagonist, displacing the performing artists from their throne. When this occurs, curating takes place in a game of mutual competition, distinction, and exploitation, in which illustration of an abstract idea or concept prevails over musical experience. Alternatively, curating may become a collective affair and responsibility along the lines of commoning principles, in which curating returns to its etymological roots as a form of caring for each other and for both the tradition and the future of music.
Peptide receptor radionuclide therapy for ectopic Cushing’s syndrome caused by metastatic neuroendocrine neoplasms
Authors: Boehm Emma , Hung Terry , Akhurst Tim , Alipour Ramin , Chiang Cherie , Hicks Rodney J , Hofman Michael S , Ravi Kumar Aravind S , Sachithanandan Nirupa , Saghebi Javad , Michael Michael , Kong Grace 
Published: October 2024

Background
Metastatic gastroenteropancreatic neuroendocrine neoplasms (GEPNEN) can cause ectopic Cushing’s syndrome (ECS). ECS is highly morbid and medical therapy is complex and can be ineffective. Patients unsuitable for bilateral adrenalectomy (BA) have dismal outcomes. Peptide receptor radionuclide therapy (PRRT) is a rational option for hormone and disease control in ECS caused by NEN with high somatostatin receptor (SSTR) expression.

Aim
To describe the characteristics and outcomes of patients with ECS treated with PRRT.

Methods
Single-centre, retrospective analysis of imaging, biochemistry and outcomes of seven consecutive patients with ECS caused by metastatic GEPNEN treated with PRRT from 2006 to 2023.

Results
Patients were aged 17–75 (female n = 6). The primary site was the pancreas (5/7) and rectum (2/7). Six patients were on medical therapy for ECS at baseline (one had a previous BA). A median of 34.4 GBq of [177Lu]Lu-DOTA-octreotate was given. [90Y]Y-DOTA-octreotate (one patient) and [111In]In-octreotide (one patient) were also used. Five patients had radiosensitising chemotherapy. Five patients had a flare of ECS within 1 week of PRRT cycle 1 (PRRT-C1). Following PRRT-C1, 5/7 patients had complete biochemical resolution of ECS at 1.5–6 months (four ongoing; one recurred after 12 months and had elective BA at 18 months). Best metabolic response on [18F]F-FDG PET/CT: Four patients had a complete metabolic response (CMR), and one had a partial metabolic response. PFS was 3–208 months. Two patients progressed at the first follow-up. The longest ECS remission and CMR continues at >17 years.

Conclusion
PRRT can be effective for ECS caused by metastatic SSTR-positive GEPNEN and should be considered in its treatment algorithm.
FERTILITY CARE IN LOW AND MIDDLE INCOME COUNTRIES: The landscape of assisted reproductive technology access in India
Authors: Tholeti Prathima , Uppangala Shubhashree , Kalthur Guruprasad , Adiga Satish Kumar 
Published: October 2024

Historically, infertility has been stigmatized in Indian society, primarily due to societal norms that equate marriage with procreation. In the twentieth century, India focused primarily on over-fertility in its family planning programs, with little attention given to the complexities of infertility. The introduction of assisted reproductive technology (ART) in the late 1970s marked a global revolution, including in India, offering hope to infertile couples. Despite a significant rise in ART clinics offering a wide range of treatment options in recent years, challenges remain, particularly regarding affordability. In India, ART is typically dominated by the private sector as government support remains limited. Efforts to standardize ART practices, including the establishment of the National ART & Surrogacy Registry and the ART Act aim to regulate, improve outcomes, and curb unethical practices. Despite these advancements, the high cost of treatment cycles and lack of insurance coverage limit couples' ability to undergo fertility treatment. Addressing these issues requires a multifaceted approach, including policy reform, increased public awareness, and the development of affordable treatment options to ensure broader access to reproductive care across India.

Lay summary
India has seen a significant rise in infertility clinics, predominantly in the private sector, catering to the need for increased infertility rates. With regulatory policies enforced by the government, standards for the establishment and functioning of assisted reproduction clinics have been prescribed. However, accessibility and affordability of these services remain a question for many infertile couples, especially in rural areas, as infertility treatment costs are high and are not subsidized by the government. Strategies are required to address the financial challenges as well as the shortage of qualified professionals in the assisted reproduction industry. In this review, we chart the development of assisted reproduction in India, with a focus on the regulatory policies and the current challenges that prevent broader access to reproductive care.
ARTIFICIAL NEURAL NETWORK APPLICATION FOR HEAVY EQUIPMENT GAS EMISSION CONTROL ON ROCK BREAKING ACTIVITY
Authors: Soerjodibroto Mulyanto , Amrizal Victor , Prabowo Wishnu 
Published: October 2024

Applications of artificial intelligence (AI) software in mining activities, both for equipment automation, data analysis and processing, identification of patterns and features data, upto determining solutions have been carried out by several mining companies. This is mainly due to mining activities naturally are always facing uncertainty and natural variability conditions. One of the AI applications is to control fuel consumption aimed at increasing the efficiency of fuel use, while in the same time reducing exhaust gas emissions from internal combustion engines, which are one of the causes of rising greenhouse gases (GHG).Utilization of AI in aimed to control fuel consumption in Rock Breaking activities in limestone quarry in the Sukabumi area, resulting a deviation rate of 0.17 for fuel consumption prediction, which is fall in “ the good category”. Increasing the volume and variety of data for “machine learning” would improve AI performance.Keywords : Artificial intelligence application, fuel consumption, ICE gas emission control.
VALUE ENGINEERING APPLICATION FOR ELEMENT ANALYSIS OF HEAVY EQUIPMENT EVACUATION TO GET HIGHER ACTIVITY VALUE
Authors: Soerjodibroto Mulyanto , Putri Nadila Guspani 
Published: October 2024

The safety of workers and equipment from the dangers of flyrock blasting is an absolute must. The purpose of this safeguard is in line with the K3 and K Operational Mining principles as emphasized in the Good Mining Practice guidelines. It is undeniable that in order to meet these safety requirements, it is necessary to sacrifice costs as well as loss of equipment production hours. With reference to the principles of Value Engineering Analysis, research was carried out in an effort to reduce these sacrifices by reducing the farthest flyrock ejection distance of bench overburden blasting at PT. Antareja Mahada Makmur site in East Kalimantan without violating the safety requirements as meant in the Minister of ESDM Decree no. 1827/2018 Attachment 2 page 79 points (ix). The research was carried out by modifying the parameters of the detonation ladder, especially those related to the explosives factor, to obtain safe distance from the farthest ejection of flyrock which is smaller than the 300 meter requirement. From the experimental series, it was obtained that the safe distance from the farthest ejection of flyrock is 150 meters as a reference for heavy equipment evacuation. This brings benefits to the company in the form of reducing sacrifices up to ± 50% from the previous without reducing the required Safety Value. Keywords : Flyrock , Safe distance , Value Engineering.
ANALISIS INKLUSI FLUIDA UNTUK EKSPLORASI MINERAL DI SUMUR UJI PEMBORAN BWS-H01, DESA SUMBERBOTO, KECAMATAN WONOTIRTO, BLITAR, JAWA TIMUR
Authors: Rachmawati Dwi 
Published: October 2024

Daerah penelitian berada di Kabupaten Blitar, Jawa Timur, Kecamatan Wonotirto, dengan koordinat 112o 08’41.71”BT-112o09’16.1”BT dan 8o14’52.94” LS-8o15’15.64”LS. Daerah penelitian merupakan bagian Zona Pegunungan Selatan Jawa Timur dan secara regional termasuk dalam Formasi Mandalika. Sumur BWS-H01 (TOD 451 m, inklinasi 90o) dan merupakan kelanjutan dari Sumur Uji yang dilakukan pada tahun 2004.Inklusi dikenal sebagai material berukuran mikro yang terdapat didalam suatu mineral, pada umumnya terdapat tiga fasa yaitu fasa padat, cair, maupun gas (Roedder, 1974; dalam Yuwono, 1994). Analisis inklusi fluida bertujuan untuk mengetahui temperatur dan salinitas pada saat pembentukan urat mineralisasi. Inklusi fluida dilakukan pada empat conto batuan pada kedalaman 257,1 m, 342 m, 401,1m dan 430,1 m . Hasil dari pengukuran keempat conto inklusi fluida menghasilkan Th (Temperatur homogenisasi) berkisar pada temperatur 100-219oC Tm (Temperatur leleh) berkisar pada temperatur -0,3 sampai -1oC, dan salinitas NaCl 0,5-1,7 %Wt NaCl. Berdasarkan kisaran temperatur 100oC-219oC, sistem hidrotermal pada sumur BWS-H01 termasuk dalam sistem epitermal. Salinitas yang rendah menunjukkan fluida yang lebih berperan berupa air meteorik yang memiliki pH netral.
STUDI FRAGMENTASI BATUAN PELEDEKAN MENGGUNAKAN METODE TOP AIR DECKING
Authors: Nabella Andromeda , Razak Supardi 
Published: October 2024

Fragementasi merupakan salah satu indikator keberhasilan dari suatu kegiatan peledakan. Lokasi penelitian telah menggunakan metode top air deck sebagai upaya menghasilkan fragmentasi yang baik. Karena belum adanya ketentuan nilai air deck length, berakibat fragmentasi kurang baik. Air deck length (ADL) merupakan parameter penting dalam penerapan peledakan air decking, dimana ADL dipengaruhi oleh nilai air deck factor (ADF). Nilai ADF ini berbeda-beda sesuai massa batuan sesuai pembobotan rock mass rating (RMR). Pada lokasi penelitian penerapan nilai ADL beragam (0,86 – 2,48 meter) dan menghasilkan nilai ADF 0,32 – 0,63. Berdasarkan analisis fragmentasi aktual diperoleh distribusi fragmentasi ukuran fragmentasi rata-rata (P80) adalah 76,34 cm dan persentase lolos rata-rata pada ukuran 75 adalah 78,6% dan persentase rata-rata boulder 21,4%. Selanjutnya dilakukanlah perhitungan ADL dengan pembobotan RMR batuan di lokasi penelitian. Pembobotan rock mass rating batuan overburden pada lokasi penelitian adalah 56 (fair). Nilai ADF yang diperoleh adalah 0,3 dan selanjutnya dilakukanlah simulasi peledakan dengan ADF 0.3. Analisis fragmentasi dari simulasi peledakan yang direkomendasikan adalah ukuran fragmentasi rata rata (P80) yang sebelumnya 76,34 cm menjadi 55,25 sehingga ukuran berkurang sebesar 21,73 cm dan persentase lolos pada ukuran 75 cm yang sebelumnya 78,6% menjadi 93% sehingga persentase lolos bertambah 14,3%. Serta persentase bouldernya menurun dari 21.4% menjadi 7%. Kata kunci: Air Deck Factor, Air Deck Length, Fragmentasi, Peledakan, Top Air Deck.
نقد متن الحديث عند نور الدين عتر وصلاح الدين الأدلبي
Authors: Pahrudin Ade , Bahrul Nurfadhilah 
Published: October 2024

Some fabricated hadiths spread in an era after the Companions, therefore, the importance of hadith criticism was underestimated. Its provenance, and had a strong influence on the later and contemporary scholars in finding the text criticism, the two researchers identified his interest in the criticism of the text of the hadith and its comparison with the contemporary scholars, Nur al-Din Atar and Salah al-Din bin Ahmed al-Idlibi, aiming to know the criticism of the text with them, and a comparison between their methodologies. The researchers' approach in this research is a comparative study, where the researchers read several books related to this research, taking the opinions of scholars from the advanced and contemporary scholars, and then making a comparison between their approaches. Among the most important results are criteria for criticizing the text, including the criteria agreed upon: (1) contrary to the Qur’an, (2) contrary to hadith, (3) contrary to reason, sense, or history, and (4) that the text does not resemble the words of the prophecy, and includes risks and weaknesses. And Samajah. And there is no difference between Salah al-Din ibn Ahmad al-Adlbi and Nour al-Din Atar in the criticism of the text except in the easy measures, which are (1) in the methodology of Nour al-Din Atar, he mentioned the rickety, and in the methodology of al-Adlbi he mentioned its addition, which is the slander and the samajah. (2) In the methodology of Nur al-Din Atar, there is a criterion: “to search for the hadith, then there is no finding among its people from the chests of the narrators and the stomachs of the books, after the hadiths have been extrapolated and written down.” However, this criterion is not found with Al-Adlbi. The approach of Nur al-Din Atar There is a measure: collecting hadith by extrapolating the chapters, and this measure does not exist with al-Adlbi. The methodology of criticism of the text according to Nur al-Din Atar and Salah al-Din ibn Ahmad al-Adlabi are all in agreement with the methodology of criticism of the text according to the audience. Keywords: matn hadith, method, criticism of hadith.
The Association of the MeMed BV Test With Radiographic Pneumonia in Children
Authors: Ramgopal Sriram , Lorenz Doug , Neveu Melissa , Krauss Jillian , Papan Cihan , Tenenbaum Tobias , Esposito Susanna , Florin Todd A. 
Published: October 2024

BACKGROUND
The MeMed BV Test produces a score that increases with increasing likelihood of bacterial infection. We evaluated its association with radiographic pneumonia in children.

METHODS
We performed a secondary analysis of a multicenter prospective study of febrile children 90 days to 18 years presenting to an emergency department. We evaluated the association of the MeMed BV test with radiographic pneumonia in adjusted logistic regression models.

RESULTS
Of 182 children, 74 (41%) had radiographic pneumonia. Among children with a high likelihood of having viral illness per the BV test, 26% had radiographic pneumonia; this increased to 64% among those with a BV test which indicated a high likelihood of bacterial infection. The sensitivity and specificity for radiographic pneumonia when using a BV test classification of moderate or high likelihood of bacterial infection were 60.8% and 62.0%, respectively. A BV test indicating the highest likelihood of bacterial infection had 23.61 higher adjusted odds (95% confidence interval 6.30–88.6) of radiographic pneumonia. The most common radiographic finding among children classified as having a high likelihood of viral infection by the BV test was interstitial opacities. The most common finding among children classified as having a high likelihood of bacterial infection were infiltrates. Except for antibiotic use, clinical outcomes occurred in similar proportions by BV category.

CONCLUSIONS
Children with moderate to high likelihoods of bacterial infection on the BV test had higher odds of radiographic pneumonia. Apart from antibiotic use, the test was not significantly associated with clinical outcomes in this study.