bluuebunny/crossref_metadata_2025_split huggingface dataset:
GeNNet: An Integrated Platform for Unifying Scientific Workflow Management and Graph Databases for Transcriptome Data Analysis
Authors: Costa Raquel L. , Gadelha Luiz M. R. , Ribeiro-Alves Marcelo , Porto Fabio 
Published: December 2016

AbstractBackgroundThere are many steps in analyzing transcriptome data, from the acquisition of raw data to the selection of a subset of representative genes that explain a scientific hypothesis. The data produced may additionally be integrated with other biological databases, such as Protein-Protein Interactions and annotations. However, the results of these analyses remain fragmented, imposing difficulties, either for posterior inspection of results, or for meta-analysis by the incorporation of new related data. Integrating databases and tools into scientific workflows, orchestrating their execution, and managingthe resulting data and its respective metadata are challenging tasks. Running in-silico experiments to structure and compose the information as needed for analysis is a daunting task. Different programsmay need to be applied and different files are produced during the experiment cycle. In this context,the availability of a platform supporting experiment execution is paramount.ResultsWe present GeNNet, an integrated transcriptome analysis platform that unifies scientific workflows with graph databases for selecting relevant genes according to the evaluated biological systems. GeNNet includes pre-loaded biological data, pre-processes raw microarray data and conducts a series of analyses including normalization, differential expression inference, clusterization and geneset enrichment analysis. To demonstrate the features of GeNNet, we performed case studies with data retrieved from GEO, particularly using a single-factor experiment. As a result, we obtained differentially expressed genes for which biological functions were analyzed. The results are integrated into GeNNet-DB, a database about genes, clusters, experiments and their properties and relationships.The resulting graph database is explored with queries that demonstrate the expressiveness of this data model for reasoning about gene regulatory networks.ConclusionsGeNNet is the first platform to integrate the analytical process of transcriptome data with graph database. It provides a comprehensive set of tools that would otherwise be challenging for non-expert users to install and use. Developers as well can add new functionality to each component of GeNNet. The resulting data allows for testing previous hypotheses about an experiment as well as exploring new ones through the interactive graph database environment. It enables the analysis of different data on humans, rhesus, mice and rat coming from Affymetrix platforms.
Sub-pixel motion estimation using phase correlation: comparisons and evaluations
Authors: Ren Jie , Zhao Huimin , Ren Jinchang , Cheng Shi 
Published: December 2016

Purpose
Effective and robust motion estimation with sub-pixel accuracy is essential in many image processing and computer vision applications. Due to its computational efficiency and robustness in the presence of intensity changes as well as geometric distortions, phase correlation in the Fourier domain provides an attractive solution for global motion estimation and image registration. The paper aims to discuss these issues.

Design/methodology/approach
In this paper, relevant sub-pixel strategies are categorized into three classes, namely, single-side peak interpolation, dual-side peak interpolation and curve fitting. The well-known images “Barbara” and “Pentagon” were used to evaluate the performance of eight typical methods, in which Gaussian noise was attached in the synthetic data.

Findings
For eight such typical methods, the tests using synthetic data have suggested that considering dual-side peaks in interpolation or fitting helps to produce better results. In addition, dual-side interpolation outperforms curve fitting methods in dealing with noisy samples. Overall, Gaussian-based dual-side interpolation seems the best in the experiments.

Originality/value
Based on the comparisons of eight typical methods, the authors can have a better understanding of the phase correlation for motion estimation. The evaluation can provide useful guidance in this context.
Moving object detection based on optical flow and neural network fusion
Authors: Qin Haiqun , Zhen Ziyang , Ma Kun 
Published: December 2016

Purpose
The purpose of this paper is to meet the large demand for the new-generation intelligence monitoring systems that are used to detect targets within a dynamic background.

Design/methodology/approach
A dynamic target detection method based on the fusion of optical flow and neural network is proposed.

Findings
Simulation results verify the accuracy of the moving object detection based on optical flow and neural network fusion. The method eliminates the influence caused by the movement of the camera to detect the target and has the ability to extract a complete moving target.

Practical implications
It provides a powerful safeguard for target detection and targets the tracking application.

Originality/value
The proposed method represents the fusion of optical flow and neural network to detect the moving object, and it can be used in new-generation intelligent monitoring systems.
Juvenile concentrations of IGF‐1 predict life‐history trade‐offs in a wild mammal
Authors: Lewin Nora , Swanson Eli M. , Williams Barry L. , Holekamp Kay E. 
Published: December 2016

Summary

Early postnatal development can have profound effects on life‐history traits later in life. One mechanism hypothesized to mediate this relationship is the anabolic hormone, insulin‐like growth factor‐1 (IGF‐1). IGF‐1 contributes importantly to postnatal growth, and thus offers a means by which environmental and genetic variation might direct organismal development, reproduction and survival.

We tested whether juvenile concentrations of IGF‐1 can predict intraspecific variation in life‐history traits later in life using longitudinal data from free‐living female spotted hyenas (Crocuta crocuta).

We found that juvenile concentrations of IGF‐1 predicted heavier juvenile mass, which in turn predicted greater survival to reproductive maturity. However, independent of mass, higher juvenile concentrations of IGF‐1 predicted earlier age at first parturition and reduced longevity in adulthood.

Our results highlight the importance of early postnatal development as a determination period in mammals and suggest that concentrations of IGF‐1 during this sensitive period can be used to predict important later‐life trade‐offs between growth, reproductive fitness and life span in wild, long‐lived animals.

A lay summary is available for this article.
Introduction: The Progressive Dilemma in British Politics
Authors: Diamond Patrick , Kenny Michael , Liddle Roger 
Published: December 2016

AbstractThis special edition reflects on the contemporary relevance of the insights and concerns of David Marquand's book The Progressive Dilemma. In this Introduction, the editors set the scene for these reflections. They consider the structural changes that have occurred in politics since the 1990s: the impact of globalisation, the erosion of class identities, the rise of ‘identity politics’ and the continued fragmentation of the party system. There has been no reconciliation between the parties of the centre‐left, nor any re‐examination of the ‘liberal tradition’ and the potential for a new synthesis with revisionist social democracy. On the one hand, Corbynism is a radicalised metropolitan species of liberalism, while on the other there are plenty in Labour who stress the need for the party to re‐engage with the traditional, socially conservative values of the working class in a new ‘postliberal’ appeal. Yet the authors argue that those who broadly identify with progressive causes in British politics—animated by the various overlapping strands of social liberalism, social democracy and liberal socialism—have still to work out how to address the historic failings that Marquand so eloquently exposed, to create a new and inspiring intellectual vision that unites and energises the left and centre‐left.
Ethics as an Enabler of Public Policy
Authors: Goodin Robert E. 
Published: December 2016

AbstractEthics constrains us. But ethics can also act as an ‘enabler’, helping to secure compliance with public policies. Basing policies on ethical principles helps the public know what is required of them by public policies. Framing policies in those ways also primes people to think in terms of their own ethically based reasons for action. Basing policies on ethical principles can assist in securing the cooperation of potential veto players by creating cooperative norms and a culture of trust.
Electrofishing method improves evaluation of amphibian larvae abundance: a case of “beaver rivers”
Authors: DGEBUADZE Yury Y. , BASHINSKIY Ivan V. 
Published: December 2016

AbstractThere are many locations in Russia where Eurasian beaver (Castor fiber) populations have been restored. As a keystone species, beavers provide wide‐ranging direct and indirect impacts on aquatic ecosystems. In particular, beaver‐created ponds are sites for spawning and nursery places for tadpoles of the brown frogs (genus Rana). Because of such impacts, study techniques for assessing aquatic organism abundance are being developed. We compared two methods for estimating tadpole abundance: traditional catches by dipnet and electrofishing. Our results show that the dipnet catch data for the shallower ponds with larger water surface area were five times lower than that obtained by electrofishing. Therefore, we conclude that dipnet catches are not suitable for comparing the relative abundance of tadpoles in the two beaver ponds that were studied.
Circulating fibroblast activation protein and dipeptidyl peptidase 4 in rheumatoid arthritis and systemic sclerosis
Authors: Sinnathurai Premarani , Lau Wendy , Vieira de Ribeiro Ana Julia , Bachovchin William W. , Englert Helen , Howe Graydon , Spencer David , Manolios Nicholas , Gorrell Mark D. 
Published: December 2016

AbstractAimTo quantify circulating fibroblast activation protein (cFAP) and dipeptidyl peptidase 4 (cDPP4) protease activities in patients with rheumatoid arthritis (RA), systemic sclerosis (SSc), and a control group with mechanical back pain and to correlate plasma levels with disease characteristics.MethodsPlasma was collected from patients with RA (n = 73), SSc (n = 37) and control subjects (n = 26). DPP4 and FAP were quantified using specific enzyme activity assays.ResultsMedian cDPP4 was significantly lower in the RA group (P = 0.02), and SSc group (P = 0.002) compared with controls. There were no significant differences in median cFAP between the three groups. DPP4 and FAP demonstrated a negative correlation with inflammatory markers and duration of disease. There were no associations with disease subtypes in RA, including seropositive and erosive disease. Decreased cDPP4 was found in SSc patients with myositis. Plasma FAP was lower in RA patients receiving prednisone (P = 0.001) or leflunomide (P = 0.04), but higher with biologic agents (P = 0.01). RA patients receiving leflunomide also had decreased cDPP4 (P = 0.014). SSc patients receiving prednisone (P = 0.02) had lower cDPP4 but there was no association with cFAP.ConclusionsNo association was found between cFAP and RA or SSc. Plasma DPP4 was decreased in RA and SSc when compared with controls. cDPP4 and cFAP correlated negatively with inflammatory markers and there were no significant correlations with disease characteristics in this RA cohort.
The Tongue Dorsal Surface in Fish: A Comparison Among Three Farmed Species
Authors: Levanti M. , Germanà A. , Montalbano G. , Guerrera M. C. , Cavallaro M. , Abbate F. 
Published: December 2016

SummaryThe oral cavity of vertebrates has a very important role in many functions strictly related to the food processing. Two species, sea bass Dicentrarchus labrax and seabream Sparus aurata, are mainly involved in the aquaculture industry in the mediterranean area; moreover, the white seabream Diplodus sargus sargus was recently chosen as the best candidate for the diversification of species of commercial interest. This investigation was carried out, using the standard procedures for light and scanning electron microscopy, to analyse the morphology of the tongue dorsal surface in order to show whether relationships are present between the tongue morphology and the nutritional choices of these species. In all the three investigated species, three different areas were observed on the dorsal lingual surface: an apex, a body and a root. In the sea bass D. labrax, numerous caninelike teeth, organized in pads, were present along the dorsal surface. The presence of numerous taste buds, scattered on the tongue, was shown. In the seabream S. aurata, the apical part of the tongue is inserted in a pouch with a characteristic medial ridge on the body surface. Numerous taste buds were scattered on the whole surface. In the white seabream D. sargus sargus, a pouch partially covering the apex was clearly observed. In the pouch, filiform‐like and foliate‐like papillae can be distinguished. The results show the important role of the fish tongue in the food ingestion process, demonstrating the interaction of food processing, taste and morphological characteristics.
Triangle of Marcille: the anatomical gateway to lateral pelvic exenteration
Authors: Lee Peter , Francis Katherine E. , Solomon Michael J. , Ramsey‐Stewart George , Austin Kirk K. S. , Koh Cherry 
Published: December 2016

BackgroundTo perform more radical surgery for complex pelvic malignancies and recurrent colorectal cancer, the surgeon must increasingly operate outside the conventional anatomical planes. Published in 1963 the ‘Triangle of Marcille’ (lumbosacral triangle) remained primarily of intellectual interest being found lateral to the traditional operating field. However, with the advancement of complex colorectal and gynaecological surgery it now provides a schema to assist surgeons in becoming acquainted with a complex and poorly understood anatomical region. Additionally, it prepares the surgeon for the extent of lateral dissection required to achieve the ‘holy grail’ for oncological surgery in pelvic malignancy, the complete resection (R0).MethodsTo prosect a preserved cadaver in order to demonstrate, in vivo, the contents and borders of the Triangle of Marcille for the purposes of teaching surgeons and future surgeons.ResultsThe Triangle of Marcille is both described and demonstrated in vivo, illustrated with diagrams and photographs. The importance of this region to the surgical management of complex colorectal and gynaecological surgery is discussed.ConclusionThe Triangle of Marcille is a vital anatomical region for advanced pelvic surgery, particularly in the current era of pelvic exenteration, and especially for those that include the lateral pelvic compartment.
Interpersonal emotion regulation in Asperger's syndrome and borderline personality disorder
Authors: López‐Pérez Belén , Ambrona Tamara , Gummerum Michaela 
Published: December 2016

ObjectivesInterpersonal emotion regulation (ER) plays a significant role in how individuals meet others’ emotional needs and shape social interactions, as it is key to initiating and maintaining high‐quality social relationships. Given that individuals with borderline personality disorder (BPD) or Asperger's syndrome (AS) exhibit problems in social interactions, the aim of this study was to examine their use of different interpersonal ER strategies compared to normative control participants.MethodsThirty individuals with AS, 30 with BPD, and 60 age‐, gender‐, and education‐matched control participants completed a battery of measures to assess interpersonal ER, which assessed to what extent participants tended to engage in interpersonal affect improvement and worsening and to what extent they used different strategies. Before completing those measures, all groups were screened for disorders of Axis I and Axis II with the Structured Clinical Interview for DSM‐IV Axis I and Axis II Disorders.ResultsCompared to controls, individuals with AS and with BPD engaged less in affect improvement. No differences were found for affect worsening. Individuals with AS reported to use less adaptive (attention deployment, cognitive change) and more maladaptive (expressive suppression) interpersonal ER strategies, compared to individuals with BPD and control participants who did not differ from each other.ConclusionsThe obtained results suggest the need to develop tailored ER interventions for each of the clinical groups studied. Furthermore, they highlight the need to study further potential differences in intrapersonal and interpersonal ER in clinical populations.Practitioner points

Individuals with Asperger's syndrome (AS) and borderline personality disorder (BPD) engaged significantly less than healthy controls in interpersonal affect improvement.

Individuals with BPD did not differ from healthy controls in the use of interpersonal strategies.

Individuals with AS reported to use more maladaptive and less adaptive strategies than BPD individuals and healthy controls.

Understanding differences in interpersonal emotion regulation in individuals with AS and with BPD and normative controls might help practitioners develop better interventions.
Changing Teacher–Child Dyadic Interactions to Improve Preschool Children's Externalizing Behaviors
Authors: Williford Amanda P. , LoCasale‐Crouch Jennifer , Whittaker Jessica Vick , DeCoster Jamie , Hartz Karyn A. , Carter Lauren M. , Wolcott Catherine Sanger , Hatfield Bridget E. 
Published: December 2016

A randomized controlled trial was used to examine the impact of an attachment‐based, teacher–child, dyadic intervention (Banking Time) to improve children's externalizing behavior. Participants included 183 teachers and 470 preschool children (3–4 years of age). Classrooms were randomly assigned to Banking Time, child time, or business as usual (BAU). Sparse evidence was found for main effects on child behavior. Teachers in Banking Time demonstrated lower negativity and fewer positive interactions with children compared to BAU teachers at post assessment. The impacts of Banking Time and child time on reductions of parent‐ and teacher‐reported externalizing behavior were greater when teachers evidenced higher‐quality, classroom‐level, teacher–child interactions at baseline. An opposite moderating effect was found for children's positive engagement with teachers.
The Development of Preschoolers’ Living Kinds Concept: A Longitudinal Study
Authors: Margett‐Jordan Tessa , Falcon Rachael G. , Witherington David C. 
Published: December 2016

Given limitations in the integrative scope of past research, basic questions about the organization and development of preschoolers’ living kinds concept remain open to debate. This study was designed to address past limitations through use of a longitudinal design, extensive stimulus set, and alternate indices of understanding. Thirty‐five English‐speaking 3‐year‐olds from middle‐class families in Albuquerque, NM participated in four testing sessions over 1 year. Indices of understanding included statements that preschoolers generated about various living and nonliving objects, biological properties they attributed to the objects, and their characterization of objects as “alive” or not. Results reveal a multifaceted picture of developmental change in preschoolers’ living kinds concept involving both the construction and elaboration of a core biological understanding.
Impact on quality of life of alitretinoin in severe chronic hand eczema: FUGETTA real‐world study
Authors: Augustin Matthias , Thaçi Diamant , Kamps Anja 
Published: December 2016

SummaryBackground and objectivesAlitretinoin is the only approved treatment for severe chronic hand eczema (CHE) refractory to potent topical corticosteroids. This study (FUGETTA) evaluated the effectiveness and impact on quality of life (QoL) of oral alitretinoin in patients with severe refractory CHE in accordance with prescription guidelines.Patients and MethodsOpen‐label, multicenter, noninterventional, observational study conducted in Germany. Patients were treated at their physician's discretion with once‐daily alitretinoin 10 mg or 30 mg for a maximum of 24 weeks. Effectiveness was assessed by Physician Global Assessment (PGA) and Dermatology Life Quality Index (DLQI). Adverse events (AEs) were assessed.ResultsThe study population included 658 patients (30 mg n = 581; 10 mg n = 77). At baseline, most patients had CHE characterized as severe by PGA (83 %). At last visit, 48 % of patients had a PGA response of clear/almost clear (30 mg: 49 %; 10 mg: 43 %). Mean improvement in DLQI scores at week 24 was 58 % (30 mg: mean [SD] change from baseline –10.4 [8.04]) and 70 % (10 mg: mean [SD] change from baseline –10.8 [7.29]). The overall incidence of AEs was low and similar in both groups.ConclusionsAlitretinoin produced rapid, marked improvement in QoL of patients with severe CHE.
Azelainsäure 20 % Creme: Auswirkung auf Lebensqualität und Krankheitsaktivität bei erwachsenen Patientinnen mit Acne vulgaris
Authors: Kainz Julius Thomas , Berghammer Gabriele , Auer‐Grumbach Piet , Lackner Verena , Perl‐Convalexius Sylvia , Popa Rodica , Wolfesberger Barbara 
Published: December 2016

ZusammenfassungHintergrundZur Wirksamkeit von Aknetherapien und deren Auswirkungen auf die Lebensqualität erwachsener Patienten liegen kaum Daten vor.ZielErhebung der Wirkung von Azelainsäure 20 % Creme (Skinoren®) auf Akne‐Schweregrad und krankheitsbedingte Lebensqualität.Patienten und MethodikNichtinterventionelle Studie bei erwachsenen Patientinnen mit leichter bis mittelschwerer Akne. Wirksamkeitsparameter waren DLQI sowie Akne‐Schweregrad im Gesicht, am Dekolleté sowie am Rücken im Gesamturteil des Prüfarztes (IGA‐Skala: Grad 1 = annähernd reine Haut; 2 = leichte Akne; 3 = mittelschwere Akne). Visiten waren zu Studienbeginn sowie nach 4–8 und zwölf Wochen geplant.ErgebnisseVon den 251 eingeschlossenen Patientinnen lag zu Studienbeginn bei 59 %, 31 % bzw. 10 % ein IGA‐Grad von 1, 2 bzw. 3 vor; die am häufigsten betroffene Hautpartie war das Gesicht (IGA‐Grad 2 oder 3: 79 %). Nach zwölf Behandlungswochen war eine signifikante Besserung der Acne vulgaris im Gesicht (IGA‐Grad 0 oder 1: 82 %) sowie auf Dekolleté und Rücken feststellbar. Der mediane DLQI‐Wert sank von neun zu Studienbeginn auf fünf nach zwölf Behandlungswochen. Neunzig Prozent der behandelnden Ärzte und Patientinnen beurteilten die Verträglichkeit der Behandlung als sehr gut oder gut.SchlussfolgerungenDie Anwendung von 20%iger Azelainsäure‐Creme führt bei erwachsenen Frauen zu einer signifikanten Besserung der Acne vulgaris und der krankheitsbedingten Lebensqualität.