bluuebunny/crossref_metadata_2025_split huggingface dataset:
Conformational changes in Arp2/3 complex induced by ATP, WASp-VCA and actin filaments
Authors: Espinoza-Sanchez Sofia , Metskas Lauren Ann , Chou Steven Z. , Rhoades Elizabeth , Pollard Thomas D. 
Published: July 2017

AbstractWe used fluorescence spectroscopy and electron microscopy to determine how binding of ATP, nucleation-promoting factors (NPF), actin monomers and actin filaments change the conformation of Arp2/3 complex during the process that nucleates an actin filament branch. We mutated subunits ofSchizosaccharomyces pombeArp2/3 complex for labeling with fluorescent dyes at either the C-termini of Arp2 and Arp3 or ArpC1 and ArpC3. We measured Förster resonance energy transfer (FRET) efficiency (ETeff) between the dyes in the presence of the various ligands. We also computed class averages from electron micrographs of negatively stained specimens. ATP binding made small conformational changes of the nucleotide binding clefts of the Arp subunits. WASp-VCA, WASp-CA, and WASp-actin-VCA changed the ETeffbetween the dyes on the Arp2 and Arp3 subunits much more than between dyes on ArpC1 and ArpC3. Ensemble FRET detected a different structural change that involves bringing ArpC1 and ArpC3 closer together when Arp2/3 complex bound actin filaments. Each of the ligands that activates Arp2/3 complex changes the structure in different ways, each leading progressively to fully activated Arp2/3 complex on the side of a filament.
Meeting halfway
Authors: Drummond Pamella , Araujo Fernando , Borges Renata 
Published: July 2017

Purpose
The purpose of this paper is to investigate the large case of enterprise resource planning (ERP) system implementation in Latin America, performed between 2011 and 2015 in a Brazilian, multinational, publicly traded company. Using the organizational change literature as background, this research analyzes the barriers and factors of success by comparing the perspectives of ERP implementers and end-users, identifying success factors and barriers of this project. A conceptual framework is developed.

Design/methodology/approach
The case study method was used to conduct an in-depth analysis of the interviews that captured the complexity of this process. The change management project team had exactly 11 implementers, of whom ten were interviewed, and 45 end-users, of whom 20 were interviewed.

Findings
The results suggest that end-users and implementers have opposite perceptions regarding the role of previous experience, organizational processes, capacity for change, leadership behavior, and the interaction of business units. In general, implementers presented a more critical perception of the change processes. Conversely, implementers and end-users agreed that business needs and cultural values facilitated the ERP implementation, whereas organizational structure and geographic dispersion constrain it.

Research limitations/implications
This research could have analyzed the results by region or by production line.

Originality/value
The major contribution of this research is to offer a conceptual framework to analyze different views about the same project. This study deepens the understanding of ERP implementations by adding studies from other countries and different cultures. For practitioners, this case study aims to offer the experiences and perceptions that implementers and end-users had about the largest ERP implementation system in Latin America.
Value co-creation in maintenance services: case study in the mechanical industry
Authors: Braun Eduardo Luiz , Pereira Giancarlo Medeiros , Sellitto Miguel Afonso , Borchardt Miriam 
Published: July 2017

Purpose
The purpose of this paper is to analyze a contract-based relationship for value co-creation and gain-sharing between two companies for the purpose of industrial maintenance services. After five years of good results for both parties, the relationship was terminated, thus raising questions regarding on the actual gains shared by both partners from joint actions.

Design/methodology/approach
The research method is the longitudinal case study. The research question is: why would a contractual relationship of co-creation of value be terminated given the fact that it yielded good financial results for both parts over the course of five years? The main research techniques were structured interviews with relevant actors and documental analysis from both parts involved in the contract.

Findings
Even valuable contracts can be terminated if the external scenario changes significantly: it matters very little the good job done together if the result became poor due to external reasons, as buyer’s sales drop in the period. In the inner scenario, mistruth can arise if the buyer maintains parallel structures for performing similar tasks to those of the service provider, showing some kind of independence from the supplier.

Research limitations/implications
The main limitation is that inherent to case studies: the lack of generalization.

Practical implications
When companies decide to contract regular long-term maintenance services, preventions to revenue reductions of the main activity the must be present, for the continuity of the contract.

Originality/value
To the date of this research, no similar study was found, regarding the influence of the external results in the internal relationships in co-creation value contracts.
Designing more just social futures or remixing the radical present?
Authors: Wargo Jon M. 
Published: July 2017

PurposePlugging into the multimodal aesthetics of youth lifestreaming, this article examines how three lesbian, gay, bisexual, transgender and/or queer (LGBTQ) youths use digital media production as an activist practice toward cultural justice work. Focusing on the queer rhetorical dimensions of multimodal (counter)storytelling, the communicative practice used to (re)name, remix and challenge epistemic notions of objective reality, this paper aims to highlight how youth worked to (de)compose and (re)author multiple identities and social relationships across online/offline contexts.Design/methodology/approachThrough sustained participant observation across online/offline contexts, active interviewing techniques and visual discourse analysis, this paper illuminates how composing with digital media was leveraged by three LGBTQ youths to navigate larger systems of inequality across a multi-year connective ethnographic study.FindingsBy highlighting how queer rhetorical arts were used as tools to surpass and navigate social fault lines created by difference, findings highlight how Jack, Andi and Gabe, three LGBTQ youths, used multimodal (counter)storytelling to comment, correct and composebeingdifferent. Speaking across the rhetorical dimensions of logos, pathos and ethos, the author contends that a queer rhetorics lens helped highlight how youth used the affordances of multimodal (counter)storytelling to lifestream versions of activist selves.Originality/valueReading LGBTQ youths’ lifestreaming as multimodal (counter)storytelling, this paper highlights how three youths use multimodal composition as entry points into remixing the radical present and participate in cultural justice work.
Leadership styles and organizational learning in UK for-profit and non-profit sports organizations
Authors: Megheirkouni Majd 
Published: July 2017

Purpose
The purpose of this study is to investigate the transformational and transactional leadership styles and organizational learning at for-profit and non-profit sports organizations, and the impact of these leadership styles on enhancing organizational learning in these sports organizations.

Design/methodology/approach
A quantitative questionnaire survey method was adopted. The data were collected from for-profit and non-profit sports organizations in the UK.

Findings
Management by exception-active in transactional leadership and idealized leadership in transformational leadership seem to be equally important for facilitating organizational learning. The results also revealed significant differences between for-profit and non-profit sports organizations in leadership styles and organizational learning.

Research limitations/implications
The generalizability of the results for different sports settings or different countries must be examined, given that only some sports organizations under the umbrellas of non-profit and for-profit sectors were used as the target population. The research is limited to the use of moderating variables, such as motivation, organizational structure, culture and innovation, that might attenuate this effect. This study contributes to the field by investigating the direct relationship between leadership styles and organizational learning in a sports setting.

Originality/value
The originality of this study is its advances of sports leadership research that is linking leadership styles and organizational learning in for-profit and non-profit sports organizations.
Effects of supportive work environment on employee retention
Authors: Kundu Subhash C. , Lata Kusum 
Published: July 2017

PurposeThe purpose of the present study is to investigate the mediating effect of organizational engagement in the relationship between supportive work environment (SWE) and employee retention.Design/methodology/approachPrimary data of 211 respondents from 67 organizations were analysed. Confirmatory factor analysis was used to assess the dimensionality and validity of study variables. Further, the hypothesized model was tested with the help of multiple regression analysis.FindingsThe findings suggest that SWE plays a crucial role in predicting employee retention. Organizational engagement partially mediates the relationship between SWE and employee retention.Research limitations/implicationsThe data were limited to the Indian setting and of cross-sectional design only; so, it may not be generalized across the world. Further, the sample size is also comparatively smaller but the results are not affected adversely.Originality/valueThe role of SWE along with organizational engagement is currently under-researched in the Indian context. The present study is an intense effort to analyse the mediating effect of organizational engagement in the relationship between SWE and employee retention.
The role of travel experience and gender on travel information source selection
Authors: Yasin Bahar , Baghirov Fakhri , Zhang Ye 
Published: July 2017

Purpose
This paper aims to identify the most popular travel information sources used among tourists and investigates how travel information selection differs across travel experience and gender.

Design/methodology/approach
This study used convenient and quota sampling strategy, questionnaires were distributed to 270 respondents at Sultanahmet and Grand Bazaar areas. A screening question was used to classify respondents.

Findings
First, past travel experience, travel agent, travel websites and hotel websites are generally the most frequently used travel information sources in destination selection due to conveniences and reliability. Second, first-timers prefer to use external information sources such as Facebook, guidebooks, travel agents and newspapers to gather information about destinations, whereas repeat visitors prefer to use internal information sources such as friends’ suggestions and past travel experience. Lastly, female visitors rely more on internal information sources such as friends’ suggestions and past travel experience. However, males prefer to use external information sources like Facebook, television, blog, travel agents, newspaper and guidebooks in choosing Turkey as a destination.

Research limitations/implications
Because factors studied, travel information sources selected, number of respondents and questionnaire distribution area are limited, future studies can expand to a bigger area so more respondents could get more reliable results.

Practical implications
This paper could help tourism industries understand searching behaviours among different types of tourists better to promote businesses in convenient sources and reach target customers easily.

Originality/value
This paper fulfils an identified need to study how travel information searching behaviours differ among tourists.
Interest rate convergence, sovereign credit risk and the European debt crisis: a survey
Authors: Gruppe Mario , Basse Tobias , Friedrich Meik , Lange Carsten 
Published: July 2017

Purpose
This paper aims to briefly review the literature on interest rate convergence and the European debt crisis with a special focus on the current fiscal problems of some governments in Europe.

Design/methodology/approach
Relevant empirical papers are identified and reviewed focusing on time series analysis techniques.

Findings
The introduction of the euro has caused interest rate convergence among European Monetary Union (EMU) government bond yields. However, now sovereign credit risk and possibly even redenomination risk have caused divergences in European bond markets.

Research limitations/implications
A major limitation is that a relatively new field of the literature is surveyed. However, there are enough papers of relevance. This review paper could therefore be helpful in finding new approaches for additional empirical research examining the EMU bond market.

Originality/value
The results of empirical studies in a relatively new field of the literature are summarized. There meanwhile are some relevant papers. A brief survey of the results of these papers is provided. Important empirical findings with regard to interest rate convergence, sovereign credit risk and redenomination risk in the EMU are discussed and evaluated. The review is especially helpful for researchers and practitioners in the field of managerial finance and risk managers in the financial services industry.
Wetland entrepreneurs: diversity in diversification in Zambian farming
Authors: McElwee Gerard , Wood Adrian 
Published: July 2017

PurposeThe purpose of this paper is to explore enterprise diversification amongst wetland farmers in Zambia as a way of reducing poverty and improving sustainability. This paper identifies ways in which such entrepreneurial activities can be supported and applied more widely.Design/methodology/approachA qualitative study of Zambian farmers, based on a series of workshops and interviews held in Zambia with farmers and farm business advisers.FindingsDespite adopting new technologies most farmers are restricted to the local market where their increased production holds down prices. However, a very small number of farmers are able to progress to production and marketing for markets in major urban centres hundreds of kilometres away, and considerably more are able to use the capital accumulated from wetland farming to diversify their household enterprises to reduce poverty and improve the sustainability and resilience of their livelihoods.Originality/valueNo work has previously been undertaken in diversification strategies of small-scale farmers in Zambia.
Routinizing peak performance and impacts via virtuous cycles
Authors: Edgeman Rick 
Published: July 2017

PurposeThe purpose of this paper is to improve the ability of enterprises to routinely realize peak performance and produce positive social and environmental impact.Design/methodology/approachAn acknowledged operational excellence model – the one behind the globally recognized Shingo Prize for Operational Excellence – is examined in relation to positive reciprocal behavior and the value of creating and reinforcing processes that “pile good upon good” in form of virtuous improvement cycles.FindingsEmbedding virtuous reciprocity cycles in enterprise culture and routines can help to routinize peak performance.Research limitations/implicationsOnly the Shingo Operational Excellence Model is examined so that other well-known alternatives such as the Malcolm Baldrige Performance Excellence Model and EFQM Excellence Model are not examined. That said, the general structure and content of most excellence models is sufficiently similar that the approach taken herein would likely yield analogous conclusions.Practical implicationsInherent in “practices” is that enterprises seek to routinize successful approaches to performance and impact, usually via contextualized implementation of excellence models or “programs” such as lean enterprise.Social implicationsOffered is one means of creating more positive enterprise cultures. Enterprises with more positive cultures have been shown to also be more productive and to contribute more positively to the fabric of society so that the “piling of good upon good” can extend beyond the borders of the enterprise.Originality/valueThe contribution herein is one of demonstrating why and how virtuous cycles can be implemented to more routinely yield improved or peak performance.
Expanding the concept of shared decision making for mental health: systematic search and scoping review of interventions
Authors: Zisman-Ilani Yaara , Barnett Erin , Harik Juliette , Pavlo Anthony , O’Connell Maria 
Published: July 2017

Purpose
Much of the existing literature on shared decision making (SDM) in mental health has focused on the use of decision aids (DAs). However, DAs tend to focus on information exchange and neglect other essential elements to SDM in mental health. The purpose of this paper is to expand the review of SDM interventions in mental health by identifying important components, in addition to information exchange, that may contribute to the SDM process in mental health.

Design/methodology/approach
The authors conducted a systematic literature search using the Ovid-Medline database with supplementary scoping search of the literature on SDM in mental health treatment. To be eligible for inclusion, studies needed to describe (in a conceptual work or development paper) or evaluate (in any type of research design) a SDM intervention in mental health. The authors included studies of participants with a mental illness facing a mental health care decision, their caregivers, and providers.

Findings
A final sample of 31 records was systematically selected. Most interventions were developed and/or piloted in the USA for adults in community psychiatric settings. Although information exchange was a central component of the identified studies, important additional elements were: eliciting patient preferences and values, providing patient communication skills training, eliciting shared care planning, facilitating patient motivation, and eliciting patient participation in goal setting.

Originality/value
The review indicates that additional elements, other than information exchange such as sufficient rapport and trusting relationships, are important and needed as part of SDM in mental health. Future SDM interventions in mental health could consider including techniques that aim to increase patient involvement in activities such as goal settings, values, and preference clarification, or facilitating patient motivation, before and after presenting treatment options.
Institutional quality and agglomeration of fast food multinationals in Latin American cities
Authors: Robles Fernando 
Published: July 2017

Purpose
The purpose of this paper is to explore the location decision of multinationals across major cities in Latin America. Based on agglomeration economics and institutional theory, the paper explores whether institutional quality of a city can temper the attraction of agglomeration factors.

Design/method/approach
The paper analyzes the geographic dispersion of three global fast-food franchise networks in 45 Latin American cities. The explanatory variables are horizontal aggregation of other multinationals and the institutional quality of a city. The direct and indirect impacts of horizontal agglomeration are explored through negative binomial regression with controls for city population and economic power [gross domestic product (GDP)].

Findings
The key finding is that location choice of fast-food networks is driven principally by market conditions and to a lesser extent by horizontal agglomeration. The institutional quality of a city has a positive influence on the agglomeration of fast-food networks. A city with strong institutional quality makes this relation stronger.

Research limitations
Other multinational and national fast-food franchises are not included in the paper. Future studies should include a greater number of global and local fast-food franchisers.

Practical implications
The positive reinforcements of agglomeration and strong institution are important for the investment location decision of fast-food multinationals. The institutional quality of the city should be an important consideration in the location decision as it expands regionally and within a country. Smaller cities may not offer the agglomeration advantages of the large metropolitan areas, but their good institutional quality may reduce the business costs for multinationals.

Social implications
Large cities in Latin America tend to reap the benefits of agglomeration. As a result, smaller secondary cities struggle to be relevant in generating economic activity and attracting private investments. One strategy to achieve relevance is to build strong and transparent institutions and a solid business environment.

Originality/value
The inclusion of institutional quality at the city level as moderation of the agglomeration factors influencing the location decision of a multinational is original. This paper contributes to our understanding of the importance of regional cities in attracting the investment of multinational firms.
Tofacitinib for the treatment of moderate to severe chronic plaque psoriasis in Japanese patients: Subgroup analyses from a randomized, placebo‐controlled phase 3 trial
Authors: Abe Masatoshi , Nishigori Chikako , Torii Hideshi , Ihn Hironobu , Ito Kei , Nagaoka Makoto , Isogawa Naoki , Kawaguchi Isao , Tomochika Yukiko , Kobayashi Mihoko , Tallman Anna M. , Papp Kim A. 
Published: July 2017

AbstractTofacitinib is an oral Janus kinase inhibitor. These post‐hoc analyses assessed tofacitinib efficacy and safety in Japanese patients with psoriasis enrolled in a 52‐week global phase 3 study. Patients received tofacitinib 5 mg, tofacitinib 10 mg or placebo twice daily (b.i.d.); placebo‐treated patients advanced to tofacitinib at week 16. Primary efficacy end‐points were the proportions of patients with 75% or more reduction from baseline Psoriasis Area and Severity Index (PASI‐75) and Physician's Global Assessment (PGA) of “clear” or “almost clear” (PGA response) at week 16. Other end‐points included: Itch Severity Item (ISI), Dermatology Life Quality Index (DLQI) score and Nail Psoriasis Severity Index (NAPSI). Adverse events (AEs) were recorded throughout the study. Overall, 58 Japanese patients were included in this analysis (tofacitinib 5 mg b.i.d., n = 22; 10 mg b.i.d., n = 24; placebo, n = 12); 29 completed the study. At week 16, significantly more patients receiving tofacitinib 5 and 10 mg b.i.d. versus placebo achieved PASI‐75 (50% and 75% vs 0%, P < 0.01) and PGA response (59% and 75% vs 0%, P < 0.001). Substantial improvements in ISI, DLQI and NAPSI score were observed with both tofacitinib doses. Over 52 weeks, similar rates of AEs were reported across treatment groups; one serious AE occurred with tofacitinib 10 mg b.i.d. Herpes zoster occurred in three patients receiving tofacitinib 10 mg b.i.d. No deaths, serious infections, malignancies or gastrointestinal perforations were reported. Results were generally consistent with global analysis, suggesting sustained efficacy and a manageable safety profile, with increased herpes zoster incidence, of tofacitinib in Japanese patients with psoriasis.