bluuebunny/crossref_metadata_2025_split huggingface dataset:
Column generation for stochastic green telecommunication network planning with switchable base stations
Authors: Villumsen Jonas Christoffer , Naoum‐Sawaya Joe 
Published: August 2016

AbstractWe present the green telecommunication network planning problem with switchable base stations, where the location and configuration of the base stations are optimized, while taking into account uncertainty and variability of demand. The problem is formulated as a two‐stage stochastic program under demand uncertainty with integers in both stages. Since solving the presented problem is computationally challenging, we develop the corresponding Dantzig‐Wolfe reformulation and propose a solution approach based on column generation. Comprehensive computational results are provided for instances of varying characteristics. The results show that the joint location and dynamic switching of base stations leads to significant savings in terms of energy cost. Up to 30% reduction in power consumption cost is achieved while still serving all users. In certain cases, allowing dynamic configurations leads to more installed base stations and higher user coverage, while having lower total energy consumption. The Dantzig‐Wolfe reformulation provides solutions with a tight LP‐gap eliminating the need for a full branch‐and‐price scheme. Furthermore, the proposed column generation solution approach is computationally efficient and outperforms CPLEX on the majority of the tested instances. © 2016 Wiley Periodicals, Inc. Naval Research Logistics 63: 351–366, 2016
The stochastic Galerkin scaled boundary finite element method on random domain
Authors: Do Duy Minh , Gao Wei , Saputra Albert A. , Song Chongmin , Leong Chi Hang 
Published: August 2016

SummaryThe research work extends the scaled boundary finite element method to non‐deterministic framework defined on random domain wherein random behaviour is exhibited in the presence of the random‐field uncertainties. The aim is to blend the scaled boundary finite element method into the Galerkin spectral stochastic methods, which leads to a proficient procedure for handling the stress singularity problems and crack analysis. The Young's modulus of structures is considered to have random‐field uncertainty resulting in the stochastic behaviour of responses. Mathematical expressions and the solution procedure are derived to evaluate the statistical characteristics of responses (displacement, strain, and stress) and stress intensity factors of cracked structures. The feasibility and effectiveness of the presented method are demonstrated by particularly chosen numerical examples. Copyright © 2016 John Wiley & Sons, Ltd.
Variational projection methods for gradient crystal plasticity using Lie algebras
Authors: Truster Timothy J. , Nassif Omar 
Published: August 2016

SummaryA computational method is developed for evaluating the plastic strain gradient hardening term within a crystal plasticity formulation. While such gradient terms reproduce the size effects exhibited in experiments, incorporating derivatives of the plastic strain yields a nonlocal constitutive model. Rather than applying mixed methods, we propose an alternative method whereby the plastic deformation gradient is variationally projected from the elemental integration points onto a smoothed nodal field. Crucially, the projection utilizes the mapping between Lie groups and algebras in order to preserve essential physical properties, such as orthogonality of the plastic rotation tensor. Following the projection, the plastic strain field is directly differentiated to yield the Nye tensor. Additionally, an augmentation scheme is introduced within the global Newton iteration loop such that the computed Nye tensor field is fed back into the stress update procedure. Effectively, this method results in a fully implicit evolution of the constitutive model within a traditional displacement‐based formulation. An elemental projection method with explicit time integration of the plastic rotation tensor is compared as a reference. A series of numerical tests are performed for several element types in order to assess the robustness of the method, with emphasis placed upon polycrystalline domains and multi‐axis loading. Copyright © 2016 John Wiley & Sons, Ltd.
Effect of Benzenetricarboxylic Ligands on the Construction of Zn(II) Coordination Polymers Based on a Flexible Imidazole‐Based Ligand
Authors: Mu Yajuan , Ran Yungen , Wu Xueyi , Deng Yuetian , Liu Jiaxu 
Published: August 2016

AbstractTwo 3D Zn(II) networks based on 1,4‐bis(2‐methylimidazol‐1‐ylmethyl)‐2,3,5,6‐tetramethylbenzene (bmimx), namely, {[Zn4(μ4‐O)(μ2‐H2O)(1,3,5‐BTC)2(bmimx)]⋅H2O}n (1) and {[Zn2(μ2‐OH)(1,2,4‐BTC)(bmimx)(H2O)]⋅2.5H2O}n (2) (1,3,5‐H3BTC=1,3,5‐benzenetricarboxylic acid, 1,2,4‐H3BTC=1,2,4‐benzenetricarboxylic acid) have been prepared at hydrothermal condition by varying the benzenetricarboxylic ligands. Single‐crystal X‐ray diffraction indicates that complex 1 shows a (3,8)‐connected net based on tetranuclear zinc(II) clusters; complex 2 shows a 8‐connected framework based on 18‐membered tetranuclear zinc(II) macrometallacycles. The results indicate that benzenetricarboxylic ligands have an important effect on the stuctural characters and ultimate frameworks. Moreover, the photoluminescence properties of the two complexes were studied in the solid state at room temperature.
Small intestinal injury in NSAID users suffering from rheumatoid arthritis or osteoarthritis
Authors: Tachecí Ilja , Bradna Petr , Douda Tomáš , Baštecká Drahomíra , Kopáčová Marcela , Rejchrt Stanislav , Lutonský Martin , Soukup Tomáš , Bureš Jan 
Published: August 2016

Abstract The goal of this prospective study was to assess non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy in patients with rheumatoid arthritis (RA) or osteoarthritis (OA) by means of non-invasive wireless capsule enteroscopy. A total of 143 patients (74 with RA, 69 with OA) treated with NSAIDs (>1 month) and 42 healthy volunteers were included. All subjects underwent capsule endoscopy, laboratory tests and filled in questionnaires. The severity of small bowel injury was graded as: mild (red spots or sporadic erosions), moderate (10–20 erosions) or severe (>20 erosions or ulcers). Capsule endoscopy identified small bowel lesions in 44.8 % of patients (mild 36.4 %, moderate 3.5 % and severe in 4.9 %). Mild non-specific lesions were found in 11.9 % healthy volunteers. There was a significantly higher prevalence of enteropathy in RA (56.8 %) compared to OA (31.9 %, p < 0.01). A significant difference between NSAID users (RA and OA) with and without enteropathy was observed in erythrocytes (p < 0.01), the leucocyte count (p < 0.05), haemoglobin (p < 0.05), haematocrit (p < 0.05), serum albumin (p < 0.01) and erythrocyte sedimentation rate (p < 0.05). No relationship was found between enteropathy and dyspepsia, gender or age. NSAID therapy is associated with a significant risk of small bowel injury. The risk is significantly higher in RA patients suggesting a possible influence of the underlying disease.Trial registration number: DRKS00004940.
On the global nonlinear instability of the rotating-disk flow over a finite domain
Authors: Appelquist E. , Schlatter P. , Alfredsson P. H. , Lingwood R. J. 
Published: August 2016

Direct numerical simulations based on the incompressible nonlinear Navier–Stokes equations of the flow over the surface of a rotating disk have been conducted. An impulsive disturbance was introduced and its development as it travelled radially outwards and ultimately transitioned to turbulence has been analysed. Of particular interest was whether the nonlinear stability is related to the linear stability properties. Specifically three disk-edge conditions were considered; (i) a sponge region forcing the flow back to laminar flow, (ii) a disk edge, where the disk was assumed to be infinitely thin and (iii) a physically realistic disk edge of finite thickness. This work expands on the linear simulations presented by Appelquist et al. (J. Fluid. Mech., vol. 765, 2015, pp. 612–631), where, for case (i), this configuration was shown to be globally linearly unstable when the sponge region effectively models the influence of the turbulence on the flow field. In contrast, case (ii) was mentioned there to be linearly globally stable, and here, where nonlinearity is included, it is shown that both cases (ii) and (iii) are nonlinearly globally unstable. The simulations show that the flow can be globally linearly stable if the linear wavepacket has a positive front velocity. However, in the same flow field, a nonlinear global instability can emerge, which is shown to depend on the outer turbulent region generating a linear inward-travelling mode that sustains a transition front within the domain. The results show that the front position does not approach the critical Reynolds number for the local absolute instability, $R=507$. Instead, the front approaches $R=583$ and both the temporal frequency and spatial growth rate correspond to a global mode originating at this position.
The SLUGGS Survey: A New Mask Design to Reconstruct the Stellar Populations and Kinematics of Both Inner and Outer Galaxy Regions
Authors: Pastorello Nicola , Forbes Duncan A. , Poci Adriano , Romanowsky Aaron J. , McDermid Richard , Alabi Adebusola B. , Brodie Jean P. , Cappellari Michele , Pota Vincenzo , Foster Caroline 
Published: August 2016

AbstractIntegral field unit spectrographs allow the 2D exploration of the kinematics and stellar populations of galaxies, although they are generally restricted to small fields-of-view. Using the large field-of-view of the DEIMOS multislit spectrograph on Keck and our Stellar Kinematics using Multiple Slits technique, we are able to extract sky-subtracted stellar light spectra to large galactocentric radii. Here, we present a new DEIMOS mask design named SuperSKiMS that explores large spatial scales without sacrificing high spatial sampling. We simulate a set of observations with such a mask design on the nearby galaxy NGC 1023, measuring stellar kinematics and metallicities out to where the galaxy surface brightness is orders of magnitude fainter than the sky. With this technique we also reproduce the results from literature integral field spectroscopy in the innermost galaxy regions. In particular, we use the simulated NGC 1023 kinematics to model its total mass distribution to large radii, obtaining comparable results with those from published integral field unit observation. Finally, from new spectra of NGC 1023, we obtain stellar 2D kinematics and metallicity distributions that show good agreement with integral field spectroscopy results in the overlapping regions. In particular, we do not find a significant offset between our Stellar Kinematics using Multiple Slits and the ATLAS3D stellar velocity dispersion at the same spatial locations.
LOESS smoothed density estimates for multivariate survival data subject to censoring and masking
Authors: Adamic Peter , Guse Jenna 
Published: August 2016

AbstractActuaries often encounter censored and masked survival data when constructing multiple-decrement tables. In this paper, we propose estimators for the cause-specific failure time density using LOESS smoothing techniques that are employed in the presence of left-censored data, while still allowing for right-censored and exact observations, as well as masked causes of failure. The smoothing mechanism is incorporated as part of an expectation-maximisation algorithm. The proposed models are applied to a bivariate African sleeping sickness data set.
Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults
Authors: Young Andrew L. , Challen Grant A. , Birmann Brenda M. , Druley Todd E. 
Published: August 2016

AbstractClonal haematopoiesis is thought to be a rare condition that increases in frequency with age and predisposes individuals to haematological malignancy. Recent studies, utilizing next-generation sequencing (NGS), observed haematopoietic clones in 10% of 70-year olds and rarely in younger individuals. However, these studies could only detect common haematopoietic clones—>0.02 variant allele fraction (VAF)—due to the error rate of NGS. To identify and characterize clonal mutations below this threshold, here we develop methods for targeted error-corrected sequencing, which enable the accurate detection of clonal mutations as rare as 0.0003 VAF. We apply these methods to study serially banked peripheral blood samples from healthy 50–60-year-old participants in the Nurses’ Health Study. We observe clonal haematopoiesis, frequently harbouring mutations in DNMT3A and TET2, in 95% of individuals studied. These clonal mutations are often stable longitudinally and present in multiple haematopoietic compartments, suggesting a long-lived haematopoietic stem and progenitor cell of origin.
Magnetic torque anomaly in the quantum limit of Weyl semimetals
Authors: Moll Philip J. W. , Potter Andrew C. , Nair Nityan L. , Ramshaw B. J. , Modic K. A. , Riggs Scott , Zeng Bin , Ghimire Nirmal J. , Bauer Eric D. , Kealhofer Robert , Ronning Filip , Analytis James G. 
Published: August 2016

AbstractElectrons in materials with linear dispersion behave as massless Weyl- or Dirac-quasiparticles, and continue to intrigue due to their close resemblance to elusive ultra-relativistic particles as well as their potential for future electronics. Yet the experimental signatures of Weyl-fermions are often subtle and indirect, in particular if they coexist with conventional, massive quasiparticles. Here we show a pronounced anomaly in the magnetic torque of the Weyl semimetal NbAs upon entering the quantum limit state in high magnetic fields. The torque changes sign in the quantum limit, signalling a reversal of the magnetic anisotropy that can be directly attributed to the topological nature of the Weyl electrons. Our results establish that anomalous quantum limit torque measurements provide a direct experimental method to identify and distinguish Weyl and Dirac systems.
Manipulating the sequence of food ingestion improves glycemic control in type 2 diabetic patients under free-living conditions
Authors: Tricò D , Filice E , Trifirò S , Natali A 
Published: August 2016

AbstractLipid and protein ingested before carbohydrate reduce postprandial hyperglycemia. We tested feasibility, safety and clinical efficacy of manipulating the sequence of nutrient ingestion in patients with type 2 diabetes (T2D). After a 4-week run-in, 17 T2D patients were randomized to either a control diet (CD) or to an experimental diet (ED) allowing the consumption of high-carbohydrate foods only after high-protein and high-fat foods at each main meal (lunch+dinner). Both diets were accurately followed and neutral on arterial blood pressure, plasma lipids and indices of hepatic and kidney function. After 8 weeks, in spite of a similar reduction of body weight (ED −1.9 95% confidence interval (−3.4/−0.4)kg, P<0.03; CD −2.0 (−3.6/−0.5)kg, P<0.02) and waist circumference (ED −2.9 (−4.3/−1.5)cm, P<0.002; CD −3.3 (−5.9/−0.7)cm, P<0.02), the ED only was associated with significant reductions of HbA1c (−0.3 (−0.50/−0.02)%, P<0.04), fasting plasma glucose (−1.0 (−1.8/−0.3)mmol l−1, P<0.01), postprandial glucose excursions (lunch −1.8 (−3.2/−0.4)mmol l−1, P<0.01; dinner: −1.0 (−1.9/−0.1)mmol l−1, P<0.04) and other indices of glucose variability (s.d.: −0.5 (−0.7/−0.2)mmol l−1, P<0.02; Coefficient of variation: −6.6 (−10.4/−2.7)%, P<0.02). When compared with the CD, the ED was associated with lower post-lunch glucose excursions (P<0.02) and lower glucose coefficients of variation (P<0.05). Manipulating the sequence of nutrient ingestion might reveal a rapid, feasible, economic and safe strategy for optimizing glucose control in T2D.
Characterization of new RNA polymerase III and RNA polymerase II transcriptional promoters in the Bovine Leukemia Virus genome
Authors: Van Driessche Benoit , Rodari Anthony , Delacourt Nadège , Fauquenoy Sylvain , Vanhulle Caroline , Burny Arsène , Rohr Olivier , Van Lint Carine 
Published: August 2016

AbstractBovine leukemia virus latency is a viral strategy used to escape from the host immune system and contribute to tumor development. However, a highly expressed BLV micro-RNA cluster has been reported, suggesting that the BLV silencing is not complete. Here, we demonstrate the in vivo recruitment of RNA polymerase III to the BLV miRNA cluster both in BLV-latently infected cell lines and in ovine BLV-infected primary cells, through a canonical type 2 RNAPIII promoter. Moreover, by RPC6-knockdown, we showed a direct functional link between RNAPIII transcription and BLV miRNAs expression. Furthermore, both the tumor- and the quiescent-related isoforms of RPC7 subunits were recruited to the miRNA cluster. We showed that the BLV miRNA cluster was enriched in positive epigenetic marks. Interestingly, we demonstrated the in vivo recruitment of RNAPII at the 3′LTR/host genomic junction, associated with positive epigenetic marks. Functionally, we showed that the BLV LTR exhibited a strong antisense promoter activity and identified cis-acting elements of an RNAPII-dependent promoter. Finally, we provided evidence for an in vivo collision between RNAPIII and RNAPII convergent transcriptions. Our results provide new insights into alternative ways used by BLV to counteract silencing of the viral 5′LTR promoter.
Hornblendite delineates zones of mass transfer through the lower crust
Authors: Daczko Nathan R. , Piazolo Sandra , Meek Uvana , Stuart Catherine A. , Elliott Victoria 
Published: August 2016

AbstractGeochemical signatures throughout the layered Earth require significant mass transfer through the lower crust, yet geological pathways are under-recognized. Elongate bodies of basic to ultrabasic rocks are ubiquitous in exposures of the lower crust. Ultrabasic hornblendite bodies hosted within granulite facies gabbroic gneiss of the Pembroke Valley, Fiordland, New Zealand, are typical occurrences usually reported as igneous cumulate hornblendite. Their igneous features contrast with the metamorphic character of their host gabbroic gneiss. Both rock types have a common parent; field relationships are consistent with modification of host gabbroic gneiss into hornblendite. This precludes any interpretation involving cumulate processes in forming the hornblendite; these bodies are imposter cumulates. Instead, replacement of the host gabbroic gneiss formed hornblendite as a result of channeled high melt flux through the lower crust. High melt/rock ratios and disequilibrium between the migrating magma (granodiorite) and its host gabbroic gneiss induced dissolution (grain-scale magmatic assimilation) of gneiss and crystallization of mainly hornblende from the migrating magma. The extent of this reaction-replacement mechanism indicates that such hornblendite bodies delineate significant melt conduits. Accordingly, many of the ubiquitous basic to ultrabasic elongate bodies of the lower crust likely map the ‘missing’ mass transfer zones.
Inversion channel diamond metal-oxide-semiconductor field-effect transistor with normally off characteristics
Authors: Matsumoto Tsubasa , Kato Hiromitsu , Oyama Kazuhiro , Makino Toshiharu , Ogura Masahiko , Takeuchi Daisuke , Inokuma Takao , Tokuda Norio , Yamasaki Satoshi 
Published: August 2016

AbstractWe fabricated inversion channel diamond metal-oxide-semiconductor field-effect transistors (MOSFETs) with normally off characteristics. At present, Si MOSFETs and insulated gate bipolar transistors (IGBTs) with inversion channels are widely used because of their high controllability of electric power and high tolerance. Although a diamond semiconductor is considered to be a material with a strong potential for application in next-generation power devices, diamond MOSFETs with an inversion channel have not yet been reported. We precisely controlled the MOS interface for diamond by wet annealing and fabricated p-channel and planar-type MOSFETs with phosphorus-doped n-type body on diamond (111) substrate. The gate oxide of Al2O3 was deposited onto the n-type diamond body by atomic layer deposition at 300 °C. The drain current was controlled by the negative gate voltage, indicating that an inversion channel with a p-type character was formed at a high-quality n-type diamond body/Al2O3 interface. The maximum drain current density and the field-effect mobility of a diamond MOSFET with a gate electrode length of 5 μm were 1.6 mA/mm and 8.0 cm2/Vs, respectively, at room temperature.
Effect of Quercetin on Hepatitis C Virus Life Cycle: From Viral to Host Targets
Authors: Rojas Ángela , Del Campo Jose A. , Clement Sophie , Lemasson Matthieu , García-Valdecasas Marta , Gil-Gómez Antonio , Ranchal Isidora , Bartosch Birke , Bautista Juan D. , Rosenberg Arielle R. , Negro Francesco , Romero-Gómez Manuel 
Published: August 2016

AbstractQuercetin is a natural flavonoid, which has been shown to have anti hepatitis C virus (HCV) properties. However, the exact mechanisms whereby quercetin impacts the HCV life cycle are not fully understood. We assessed the effect of quercetin on different steps of the HCV life cycle in Huh-7.5 cells and primary human hepatocytes (PHH) infected with HCVcc. In both cell types, quercetin significantly decreased i) the viral genome replication; ii) the production of infectious HCV particles and iii) the specific infectivity of the newly produced viral particles (by 85% and 92%, Huh7.5 and PHH respectively). In addition, when applied directly on HCV particles, quercetin reduced their infectivity by 65%, suggesting that it affects the virion integrity. Interestingly, the HCV-induced up-regulation of diacylglycerol acyltransferase (DGAT) and the typical localization of the HCV core protein to the surface of lipid droplets, known to be mediated by DGAT, were both prevented by quercetin. In conclusion, quercetin appears to have direct and host-mediated antiviral effects against HCV.
Developmental transcriptome analysis and identification of genes involved in formation of intestinal air-breathing function of Dojo loach, Misgurnus anguillicaudatus
Authors: Luo Weiwei , Cao Xiaojuan , Xu Xiuwen , Huang Songqian , Liu Chuanshu , Tomljanovic Tea 
Published: August 2016

AbstractDojo loach, Misgurnus anguillicaudatus is a freshwater fish species of the loach family Cobitidae, using its posterior intestine as an accessory air-breathing organ. Little is known about the molecular regulatory mechanisms in the formation of intestinal air-breathing function of M. anguillicaudatus. Here high-throughput sequencing of mRNAs was performed from six developmental stages of posterior intestine of M. anguillicaudatus: 4-Dph (days post hatch) group, 8-Dph group, 12-Dph group, 20-Dph group, 40-Dph group and Oyd (one-year-old) group. These six libraries were assembled into 81300 unigenes. Totally 40757 unigenes were annotated. Subsequently, 35291 differentially expressed genes (DEGs) were scanned among different developmental stages and clustered into 20 gene expression profiles. Finally, 15 key pathways and 25 key genes were mined, providing potential targets for candidate gene selection involved in formation of intestinal air-breathing function in M. anguillicaudatus. This is the first report of developmental transcriptome of posterior intestine in M. anguillicaudatus, offering a substantial contribution to the sequence resources for this species and providing a deep insight into the formation mechanism of its intestinal air-breathing function. This report demonstrates that M. anguillicaudatus is a good model for studies to identify and characterize the molecular basis of accessory air-breathing organ development in fish.