bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive evaluation of an artificial intelligence based digital pathology to monitor large-scale deworming programs against soil-transmitted helminths: A study protocol
Authors: Ward Peter K. , Roose Sara , Ayana Mio , Broadfield Lindsay A. , Dahlberg Peter , Kabatereine Narcis , Kazienga Adama , Mekonnen Zeleke , Nabatte Betty , Stuyver Lieven , Velde Fiona Vande , Hoecke Sofie Van , Levecke Bruno 
Published: October 2024

Background
Manual screening of a Kato-Katz (KK) thick stool smear remains the current standard to monitor the impact of large-scale deworming programs against soil-transmitted helminths (STHs). To improve this diagnostic standard, we recently designed an artificial intelligence based digital pathology system (AI-DP) for digital image capture and analysis of KK thick smears. Preliminary results of its diagnostic performance are encouraging, and a comprehensive evaluation of this technology as a cost-efficient end-to-end diagnostic to inform STH control programs against the target product profiles (TPP) of the World Health Organisation (WHO) is the next step for validation.

Methods
Here, we describe the study protocol for a comprehensive evaluation of the AI-DP based on its (i) diagnostic performance, (ii) repeatability/reproducibility, (iii) time-to-result, (iv) cost-efficiency to inform large-scale deworming programs, and (v) usability in both laboratory and field settings. For each of these five attributes, we designed separate experiments with sufficient power to verify the non-inferiority of the AI-DP (KK2.0) over the manual screening of the KK stool thick smears (KK1.0). These experiments will be conducted in two STH endemic countries with national deworming programs (Ethiopia and Uganda), focussing on school-age children only.

Discussion
This comprehensive study will provide the necessary data to make an evidence-based decision on whether the technology is indeed performant and a cost-efficient end-to-end diagnostic to inform large-scale deworming programs against STHs. Following the protocolized collection of high-quality data we will seek approval by WHO. Through the dissemination of our methodology and statistics, we hope to support additional developments in AI-DP technologies for other neglected tropical diseases in resource-limited settings.

Trial registration
The trial was registered on September 29, 2023 Clinicaltrials.gov (ID: NCT06055530).
Neighborhood socioeconomic factors and characteristics correlated with avoidable emergency department visits: A spatial analysis of a Canadian academic hospital
Authors: Strum Ryan P. , McLeod Brent , Costa Andrew P. , Mondoux Shawn 
Published: October 2024

Introduction
The influence of neighborhood characteristics and socioeconomic status (SES) factors on avoidable emergency department (ED) utilization is not well understood in a universal healthcare system. We examined correlations between these factors and avoidable ED visits at a Canadian academic hospital.

Materials and methods
We conducted a retrospective cohort study using administrative ED data from a hospital in Hamilton, Canada from April 1, 2018 to August 31, 2023, and neighborhood data from the Statistics Canada Census of Population 2021. Avoidable visits were classified using the Emergency Department Avoidability Classification (EDAC), and mapped to neighborhoods using Canadian postal codes. SES was defined primarily based on education attained, household income, employment and housing security. The top 20 postal codes with the highest avoidable ED visits were categorized into quartiles and analyzed for trends using chi-squared tests of spatial association and Spearman rank correlations.

Results
A consistent ordinal trend across quartiles was observed throughout the study period, with quartile 1 representing the lowest avoidable ED visits and quartile 4 the highest. The quartiles were unevenly distributed spatially, though there was a significant association between close proximity to the ED and avoidable visits (X2 = 7.07, p <0.05). The quartile with the highest avoidable ED visits (quartile 4) had the greatest proportion of one-person households (35.5%) and one-parent families (37.8%), and showed statistically significant positive correlations with male sex, living alone and having an indigenous identity. Quartile 4 had the highest rates of individuals not completing high school (18.6%, p < 0.05), unemployment (13.7%), households spending greater than 30% of their income on shelter (26.5%), and households earning less than $30,000 annually (16.6%, compared to 8.7% in quartile 1 with the lowest avoidable ED visits).

Discussion
In a universal healthcare setting, lower SES neighborhoods were correlated with higher rates of avoidable ED visits. Targeted interventions that address social determinants of health disparities in neighborhoods with lower SES could reduce the burden of avoidable ED visits, and promote more equitable healthcare utilization.
Measurement invariance of the Center for Epidemiological Studies-Depression scale and associations with genetic risk in older adults
Authors: Saari Toni T. , Piirtola Maarit , Aaltonen Aino , Palviainen Teemu , Varjonen Anni , Julkunen Valtteri , Rinne Juha O. , Kaprio Jaakko , Vuoksimaa Eero 
Published: October 2024

Background
As populations are aging, it needs to be ensured that valid depression rating scales are available across old adulthood. Center for Epidemiological Studies-Depression scale (CES-D) is a common depression rating scale, however, few studies have assessed its validity in individuals with age over 90 and/or cognitive impairment. We examined the factor structures of 20-, 15-, and 8-item CES-D scales, their measurement invariance for age and cognition, and associations with genetic risk of depression.

Methods
Participants were from a population-based older Finnish Twin Cohort study including 71–79-year-olds from the MEMTWIN II (n = 1034 for exploratory and n = 664 for confirmatory factor analyses) and 90+ year-olds from the NONAGINTA (n = 134, confirmatory factor analyses) sub-studies. Associations of polygenic risk score of major depressive disorder (MDD-PRS) with CES-D scales were examined in MEMTWIN II.

Results
Exploratory factor analyses (n = 1034) suggested four- (CES-D 20) and three-factor (CES-D 8) structures and these models fit well in confirmatory analyses (n = 664). Unidimensional models had good (CES-D 15 & 20) or fair fit (CES-D 8). Results supported scalar invariance of all CES-D versions for age and cognitive status. Higher MDD-PRS was associated with more depressive symptoms in different CES-D versions.

Conclusions
Different CES-D versions are adequate for measuring depressive symptoms across age groups and cognitive spectrum in old age. Genetic risk of depression predicts depressive symptoms even in old age.
Clinical significance of MRI-measured olfactory bulb height as an imaging biomarker of idiopathic Parkinson’s disease
Authors: Park Sohyun , Lee Jungbin , Kim Jung Youn , Park Jeong-Ho , Lee Ji Eun , Park Sang Ik , Yim Younghee 
Published: October 2024

Objectives
This study aimed to determine whether the olfactory bulb height (OBH) measured using magnetic resonance imaging (MRI) has clinical utility as an imaging biomarker in the evaluation of patients with idiopathic Parkinson’s disease (iPD) through its correlation with movement impairment.

Methods
This retrospective study included cognitively intact patients with suspected parkinsonism. All participants underwent T2-weighted imaging to measure OBH. Logistic regression was used to determine whether OBH was an independent risk factor for distinguishing iPD patients from disease controls, and its relation with clinical parameters related to motor impairment, including clinical laterality, modified Hoehn and Yahr (HY) stage, and Unified Parkinson’s Disease Rating Scale (UPDRS) III score, was investigated.

Results
Based on the final clinical diagnosis, 79 patients with iPD and 16 disease controls were included. The mean OBH was significantly smaller in iPD than in disease controls (p < 0.0001). OBH was a significant independent predictor of iPD, with a cutoff of 1.52 mm. In the comparison among the ipsilateral, contralateral side of iPD with clinical laterality, and disease control group, the OBH of the disease control group was significantly larger than both the ipsilateral and contralateral sides (P < 0.05). However, there was no significant difference in OBH between the ipsilateral and contralateral sides (p > 0.05). OBH according to HY stage was significantly smaller in HY stage 2–3 groups than in the disease control group (p < 0.001). The correlation analysis between UPDRS III and OBH showed a mild negative correlation (r = -0.32, p = 0.013).

Conclusions
MRI-measured OBH is decreased in iPD regardless of age and sex and may be correlated with the progression of motor symptoms in the iPD.
Suggestion on the elderly care model specific to Türkiye
Authors: Görecek Permin , Acuner Deniz 
Published: October 2024

The world population is aging as a result of increasing life expectancy and decreasing birth rates. Since Turkey is among the fastest aging countries in the world, social aging is expected to emerge as a significant problem in the coming years. This research is a qualitative study conducted to determine suggestions for creating an elderly care model specific to Turkey. In this context, in-depth interviews were conducted face to face or online with eight participants providing elderly care services and seven participants receiving the service. Participants were determined by snowball sampling method. Semi-structured questionnaires were used as data collection tools and the obtained data were analyzed using the MAXQDA computer program. The expressions used by the participants in the interviews were coded 306 times under 86 headings and collected under four themes. "Health services provided to the elderly" was the theme with the most codes (33.01%). “Care services for the elderly” was coded 92 times (30.07%), “Social services and social assistance for the elderly” was coded 76 (24.84%) and “Financing, social security system and legal regulations” was coded 37 (12.09%) times. . As a result of the research, suggestions were made for the elderly care model specific to Turkey to improve the health system offered to the elderly, strengthen the social security system, improve care services for the elderly and strengthen social services and social assistance for the elderly.
(Extended English summary is at the end of this document)

Özet
Yaşam süresinin uzaması ve doğum oranlarının düşmesi sonucunda dünya nüfusu yaşlanmaktadır. Türkiye, dünyada en hızlı yaşlanan ülkeler arasında yer aldığı için gelecek yıllarda toplumsal yaşlanmanın önemli bir problem olarak ortaya çıkması beklenmektedir. Bu araştırma, Türkiye’ye özgü yaşlı bakım modeli oluşturulmasına yönelik öneriler belirlemek amacıyla yapılan niteliksel bir çalışmadır. Bu kapsamda yaşlı bakım hizmeti sunan sekiz ve hizmeti alan yedi katılımcı yüz yüze ya da online olarak derinlemesine görüşme gerçekleştirilmiştir. Katılımcılar kartopu örnekleme yöntemi ile belirlenmiştir. Veri toplama aracı olarak yarı yapılandırılmış soru formları kullanılmış ve elde edilen veriler, MAXQDA bilgisayar programı kullanılarak analiz edilmiştir. Görüşmelerde katılımcıların kullandıkları ifadeler 86 başlık altında 306 kez kodlanmış ve dört tema altında toplanmıştır. “Yaşlılara sunulan sağlık hizmetleri” en çok kod içeren tema olmuştur (%33,01). “Yaşlılara yönelik bakım hizmetleri” 92 (%30,07), “Yaşlılara yönelik sosyal hizmetler ve sosyal yardımlar” 76 (%24,84) ve “Finansman, sosyal güvenlik sistemi ve hukuki düzenlemeler” 37 (%12,09) kez kodlanmıştır. Araştırma sonucunda, Türkiye’ye özgü yaşlı bakım modeli için yaşlılara sunulan sağlık sistemini iyileştirilmesi, sosyal güvenlik sistemini güçlendirilmesi, yaşlılara yönelik bakım hizmetlerinin iyileştirmesi ve yaşlılara yönelik sosyal hizmetler ve sosyal yardımları güçlendirmesine yönelik önerilerde bulunulmuştur.
Prediction of the potential Brazilian distribution for invasive mollusc Melanoides tuberculata (Müller, 1774), including a new record from Northern Coastal Region
Authors: CARVALHO MAYARA CAROLYNE MOURÃO , ABREU ALDEANE SOARES DE , SILVA MAURICIO SANTOS DA , CANTANHEDE SELMA PATRICIA DINIZ , MONROE THERCIA GONÇALVES RIBEIRO , ARAÚJO LUDMILA SEREJO , TCHAICKA LIGIA 
Published: October 2024

The freshwater snail Melanoides tuberculata (Müller, 1774) native from Africa and Asia, recently spreads out over the world. Records of invasive species are extremely important, because it helps in future invasions mitigation. Here, we report for the first time the occurrence of M. tuberculata in a protected area of Northern Brazilian Coast and use predictive distribution modeling to know the potential Brazilian distribution for this species. The gastropod M. tuberculata were collected in the municipalities of Tutóia and Santo Amaro - Maranhão State. According to the results of the predictive map distribution for Brazil, the regions with the highest susceptibility are the northeast, southeast and midwest. Preciptation of month and Isothermalithy were de variables that most contribute to the species’ potential distribution. This species presented high to medium suitability of occurrence in 32 national protected areas. Futher studies are recommended to monitor the growth and dispersion, in order to determine its real impact.
Crystal structure of (E)-2-(4-(1H-imidazol-1-yl)benzylidene)-7-fluoro-3,4-dihydronaphthalen-1(2H)-one, C20H15FN2O
Authors: Chen Yu , Wang Ji-Peng , Wang Mei-Dan , Yu Wen-Xiao , Cui Yao-Tian , Gao Hao-Xue , Hou Gui-Ge , Ren Yan 
Published: October 2024

Abstract
C20H15FN2O, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 8.0724(1) Å, b = 9.6473(1) Å, c = 9.6635(1) Å, α = 80.903(1)°, β = 82.325(1)°, γ = 84.147(1)°, V = 733.922(14) Å3, Z = 2, Rgt
(F) = 0.0366, wRref
(F
2) = 0.0934, T = 293 K.
The co-crystal structure of 4-chlorobenzophenone–salicylhydrazide(1/1), C20H17ClN2O3
Authors: Wang Ji , Wu Wenhui , Zhang Wencai , Yang Xiying , Qiao Jie 
Published: October 2024

Abstract
C20H17ClN2O3, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 6.2486(3) Å, b = 7.4746(4) Å, c = 19.0245(10) Å, α = 89.341(2)°, β = 85.998(2)°, γ = 83.651(2)°, V = 880.94(8) Å3, Z = 2, R
gt(F) = 0.0351, wRref
(F
2) = 0.0970, T = 289 K.
The crystal structure of the co-crystal composed of benzhydrazide and 5-aminoisophthalic acid, C8H7NO4⋅C7H8N2O
Authors: Bourletidis How Jeraldine Maire , Scheepers Matthew C. , Lemmerer Andreas , Smith Mark G. 
Published: October 2024

Abstract
C8H7NO4⋅C7H8N2O, monoclinic, P21/n (no. 14), a = 18.3690(6) Å, b = 3.8010(1) Å, c = 21.5232(7) Å, β = 108.867(1)∘, V = 1422.02(8) Å3, Z = 4, R

gt
(F) = 0.0340, wR

ref
(F
2) = 0.0959, T = 173 K.
Crystal structure of (3,6-di(2-pyridyl)-4-phenylaminopyridazine-κ2N,N′)-bis(2-(p-toluene)pyridinyl-κ2C,N)-iridium(III) hexafluorophosphate –dichloromethane (1/1), C45H37Cl2F6IrN7P
Authors: Qian Jun , Ma Liang , Wang Yida 
Published: October 2024

Abstract
C45H37Cl2F6IrN7P, monoclinic, P21/c (no. 14), a = 23.518(5) Å, b = 11.702(2) Å, c = 15.426(3) Å, β = 101.44(3)°, V = 4161.0(15) Å3, Z = 4, R

gt
(F) = 0.0474, wR

ref
(F
2) = 0.0924, T = 293 K.
Current advancements in PD-L1 modulation by CMTM6 in malignant tumors
Authors: Zhang Lisha , He Sisi , Wu Lixing , Wang Xiangqin , Bai Yuju 
Published: October 2024

Abstract
The CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6), a member of the chemokine-like factor superfamily, binds to programmed death-ligand 1 (PD-L1) on the cell membrane, thereby impeding PD-L1’s lysosomal degradation and sustaining its expression. In recent years, extensive studies on PD-L1 have provided insights into its function as an immunepoint inhibitor involved in tumor cell immune evasion. The specific interaction between CMTM6 and PD-L1 suggests a potential role in tumor cell immune evasion and suppression, potentially offering a novel therapeutic target for cancer immunotherapy. Currently, the research on CMTM6 and PD-L1 in diverse tumors and diseases is limited, but their significant roles are indicated. This article provides an overview of the impact of CMTM6 on the immune microenvironment in different types of cancer (such as lung cancer, breast cancer, and liver cancer), and summarizes the effects of CMTM6 on the occurrence and development of various tumors.
Efficacité des conférences d’éducation publique liées à la vision
Authors: Labreche Tammy , Irving Elizabeth 
Published: October 2024

Contexte : L’éducation publique digne de confiance est jugée essentielle pour garantir que la population canadienne reçoive des soins oculovisuels opportuns, uniformes et complets. Les conférences de sensibilisation du public sont une méthode de diffusion de cette information. Le but de cette étude était de déterminer l’efficacité de ces conférences pour atteindre leurs objectifs éducatifs.
Méthodes : Un sondage préalable et postérieur a été créé et diffusé lors d’une conférence d’éducation publique organisée par le Centre for Sight Enhancement. Les questions du sondage portaient sur la perception des connaissances acquises, les attitudes à l’égard de la présence de symptômes de maladie oculaire et l’importance des examens de la vue.
Résultats : Sur les 74 personnes participantes, 27 ont répondu au sondage préalable et 24 ont répondu au sondage après la conférence. Il y a eu une augmentation statistiquement significative des connaissances perçues acquises dans tous les secteurs de conférence. Il n’y a pas eu d’amélioration statistiquement significative de la sensibilisation à la nature asymptomatique des maladies oculaires précoces ou à l’importance des examens de la vue.
Conclusion : Les conférences d’éducation du public sont une méthode efficace de diffusion des connaissances sur les soins oculovisuels, mais il faudra effectuer d’autres recherches pour déterminer si elles peuvent aider à modifier les tendances de recherche de soins oculovisuels.
Experiences of Undergraduate Students Enrolled in a University Instructional Physical Activity Course: Exploring Factors Contributing to Behavior Modification
Authors: Brock Sheri , Hollett Nikki 
Published: October 2024

Background: There is a trend of decreased daily physical activity among college students. Demands of coursework, hectic schedules, and stress often prevent students from engaging in regular exercise, leading to negative impacts on mental and physical well-being. University Instructional Physical Activity Programs have the potential to address this issue by offering courses that can encourage healthier habits and promote wellness.
Aim: The purpose of this study was to analyze the experiences of undergraduate students enrolled in a two-credit elective physical activity course.
Methods: Participants were 587 undergraduate students enrolled in an online instructional physical activity course. Data collection included a survey consisting of three questions on a five-point Likert scale and one open-ended response regarding their experience in the course.
Results: Descriptive survey data indicated positive trends regarding participants’ experience. Based on thematic analysis, qualitative data produced four themes including (1) awareness, (2) accountability, (3) ease and convenience, and (4) behavior change.
Conclusions: Participants had an overall positive response to wearing an activity tracker in an online physical activity course and believed the awareness the activity tracker provided changed their daily behaviors, enabled health outcomes, and changed future intentions for physical activity. This study provides insight into the inclusion of technology to facilitate physical activity in college-age students.
Aim: The purpose of this study was to analyze the experiences of undergraduate students enrolled in a two-credit elective physical activity course.
Methods: Participants were 587 undergraduate students enrolled in an online instructional physical activity course. Data collection included a survey consisting of three questions on a five-point Likert scale and one open-ended response regarding their experience in the course.
Results: Descriptive survey data indicated positive trends regarding participants’ experience. Based on thematic analysis, qualitative data produced four themes including (1) awareness, (2) accountability, (3) ease and convenience, and (4) behavior change.
Conclusions: Participants had an overall positive response to wearing an activity tracker in an online physical activity course and believed the awareness the activity tracker provided changed their daily behaviors, enabled health outcomes, and changed future intentions for physical activity. This study provides insight into the inclusion of technology to facilitate physical activity in college-age students.
Modern etiotropic therapy of chronic viral hepatitis B
Authors: Bun'kova E. B. , Bileva N. A. , Bilev A. E. , Sinel'nikov M. I. 
Published: October 2024

Chronic viral hepatitis B (CHB) is a significant global health problem. The biological characteristics of the hepatitis B virus, which causes this disease, significantly impede the achievement of complete virus elimination in most patients. In this regard, the rational choice of drugs and antiviral therapy regimens is crucial for increasing life expectancy and improving the quality of life in patients with CHB. The purpose of this literature review is to identify current approaches and trends in etiotropic therapy for CHB.Materials and methods. The review uses data published in domestic and foreign scientific journals, clinical guidelines, regulatory documents, and Internet resources.Results. Currently, the most effective means of etiotropic therapy for CHB are interferons (standard interferon alpha, pegylated interferons alpha-2a and alpha-2b), as well as first-line nucleoside/nucleotide analogs (entecavir, tenofovir) and second-line analogs (lamivudine, telbivudine, adefovir). The choice of a specific drug is determined by the patient's clinical condition, preferences, availability, and cost of treatment. Despite certain limitations of current etiotropic therapies for CHB, their use can significantly increase patients' life expectancy and improve their quality of life.
Multimedia electronic manual "Thermometry"
Authors: Dyachkov V. A. , Rubanenko A. O. , Garanin A. A. 
Published: October 2024

Relevance. The education system plays a crucial role in the formation of professional orientation in the learning process. The digital transformation of education has become an integral part of the development of our society. One of the effective tools in the context of the activation of digital didactics to improve the quality of educational services is the introduction of modern distance learning technologies.Aim. Creation of a multimedia electronic manual dedicated to teaching the discipline "Propaedeutics of internal diseases" on the topic "Thermometry".Materials and methods. The multimedia electronic manual "Thermometry" developed at the Propaedeutic Therapy Department in Samara State Medical University contains theoretical material on the methodology and technique of measuring body temperature. The manual provides illustrative material with illustrations and description of the main types of fevers, describes the grades of fever, provides a detailed description of the rules for the registration of a temperature chart and provides an example of a filled temperature chart. The presented multimedia electronic manual contains a set of tests and clinical cases for self-monitoring of students' knowledge with references.Conclusion. The multimedia electronic manual "Thermometry" developed at Samara State Medical University can increase the efficiency of learning the material, which will help to improve the formation of professional competencies among students, while examining patients of various profiles, making correct diagnosis and management strategy.