bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adoption, Acceptability, and Effectiveness of Community Software LINE Official Account for Oncological Case Management of Patients with Oral Cancer at Medical Center
Authors: Hsieh Ming- Hsin , Chang Ying-Ying , Wu Hsing-Ling Carol , Chou Yu-Shu , Chang Chia-Hui 
Published: October 2024

Abstract

Background: Cancer patients require cross-professional care during the diagnosis and treatment periods. Moreover, patients who recover from oral cancer often require an interdisciplinary team during the rehabilitation and tracking periods. Therefore, methods for effectively carrying out case management are essential to tumor care.
Purpose: To investigate the effects of using the community software LINE Official Account on oncological case management with oral cancer, with the app providing self-care information and health-care advice. Methods: An experimental design was used; 100 patients with oral cancer participated. The patients were randomly divided into two groups by using a computer-generated random number table. The experimental group comprised 55 patients, whereas the control group included 45 patients. The experimental group used LINE Official Account, which gave them self-care information, timely messages, and one-on-one health-care consultations. The control group followed standard health-care practices.
Results: In total, 40 patients in the experimental group were satisfied with the self-care information provided by LINE Official Account (86.9%). In total, 42 patients regularly checked the self-care information (89.4%). Among these patients, 25 of them would check the information when receiving a push notification (54.3%). Ten patients used the one-on-one health-care consultation system (20.0%). Their questions concerned oral infection, language and swallowing problems, nutrition, chemotherapy, psychological support, and registration problems. LINE Official Account had a significant effect on the rate of participation in support groups. Generalized estimating equations indicated a significant difference between the two groups regarding overall quality of life over 7 days (P = 0.023).
Conclusion: Community software applications used in oncological case management can improve the self-management of patients and empower them. Moreover, applications also enable to track long-term follow-up effectiveness and reinforce the case manager’s role as a family therapist. Case managers are professionals to which patients can turn without needing to register or be referred. Therefore, this study recommends that case manager systems be incorporated into mobile applications to increase the sustainable management, accessibility, effectiveness, and satisfaction of oncological management systems. This study also provides the value of Sustainable Development Goals (SDGs) with Good Health and Well-being, and decreased social withdrawal among patients with oral cancer.
SIRT2 Inhibition Enhances Mitochondrial Apoptosis in Brucella-Infected Bovine Placental Trophoblast Cells
Authors: Zhang Mengyu , Qi Lin , Li Junmei , Yuan NingQiu , Zhai Yunyi , Hao Mingyue , Zhou Dong , Liu Wei , Jin Yaping , Wang Aihua 
Published: October 2024

Abstract

Brucella being a successful pathogen, employs a plethora of immune evasion mechanisms. This contributes to pathogenesis, persistence and also limits the efficacy of available treatment. Increasing understanding of host-pathogen interactions suggests that integrating host-directed strategies with existing anti-Brucella treatments could lead to more effective bacterial clearance and a reduction in drug-resistant strains. SIRT2 is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase found in mammals. It can deacetylate various transcription factors and regulatory proteins, playing a crucial role in host-pathogen interactions and pathogen infection-induced apoptosis. In this study, we investigate the role of SIRT2 in Brucella-induced cell apoptosis using bovine placental trophoblast cells. Our results indicate that B. abortus A19 infection upregulates SIRT2 protein expression and significantly induces mitochondrial apoptosis in these cells. Furthermore, Inhibition of SIRT2 exacerbates B. abortus A19-induced mitochondrial apoptosis and markedly inhibits intracellular bacterial survival. These results prove the role of SIRT2 in Brucella pathogenesis and the mechanism of action.
Treatment of single-segment lumbar tuberculosis by unilateral biportal endoscopic debridement, interbody fusion, and percutaneous pedicle screw fixation
Authors: Wang Xiangbin , Li Tao , Li Yong , Long Yubin 
Published: October 2024

Abstract

Introduction: Unilateral biportal endoscopic (UBE) technique is an emerging minimally invasive spinal surgical technique that has been used to treat a variety of degenerative spinal diseases in recent years, while there are rare reports on the treatment of lumbar tuberculosis (LTB). Consequently, this study intends to investigate the effectiveness and feasibility of UBE debridement, interbody fusion, and percutaneous pedicle screw fixation for single-segment LTB. Methods: A total of 31 patients with single-segment LTB from January 2020 to September 2021 were included. The operative time, estimated blood loss, time to ambulation, postoperative hospital stay, and complications were recorded. Clinical outcomes include erythrocyte sedimentation rate (ESR), c-reactive protein (CRP), the visual analog scale (VAS) score, Oswestry disability index (ODI), American Spinal Injury Association (ASIA) neurological classification, Cobb angle, and lumbar lordotic angle were analyzed. X-rays or computerized tomography (CT) were reviewed 6 months after surgery and at the final follow-up, and surgical segmental fusion was evaluated using Bridwell grading criteria. Results: The mean operative time was 171.61 ± 19.03 minutes, the mean estimated blood loss was 243.87 ± 26.54 ml, the mean time to ambulation was 1.87 ± 0.76 days postoperatively, and the mean postoperative hospital stay was 5.61 ± 1.17 days. There were 4 cases of procedure-related complications and the incidence was 12.9%. The levels of ESR and CRP returned to normal 3 months after the procedure. VAS scores of low back and leg, as well as ODI, were significantly improved postoperatively compared with before the operation, and the differences were statistically significant (P < 0.05). All patients were ASIA grade E at the last follow-up. The postoperative Cobb angle was 9.81 ± 2.4°, the lumbar lordotic angle was 42.59 ± 6.16°, and both had no significant loss of correction during the final follow-up. Bony fusion was achieved in all cases at the final follow-up. Conclusions: UBE debridement, interbody fusion, and percutaneous pedicle screw fixation is a feasible, effective, and safe surgical procedure for the treatment of single-segment LTB.
Prognostic Nutritional Index in Risk of Mortality Following Fulminant Myocarditis
Authors: Doi Shunichi , Ishibashi Yuki , Suzuki Norio , Miyahara Daisuke , Sato Yukio , Kuwata Shingo , Kida Keisuke , Izumo Masaki , Onoue Kenji , Kanaoka Koshiro , Saito Yoshihiko , Akashi Yoshihiro J. 
Published: October 2024

Abstract

Aims
Fulminant myocarditis (FM) is an acute fatal inflammation disease, but its chronic phase is unclear. A Japanese nationwide registry evaluated the long-term mortality in FM patients using a prognostic nutritional index (PNI).
Methods and Results
The retrospective cohort study included patients with clinically suspected or histologically proven FM available for PNI. PNI was assessed on admission and at discharge. We divided patients into two groups based on PNI at discharge (PNI ≤ 40 or PNI > 40) and analyzed the change in PNI and mortality between the groups. Of 323 patients (the median [first-third quartiles] age of this cohort was 50 [37–64] years, and 143 [44%] were female), PNI ≤ 40 at discharge was in 99 (31%) patients. The median PNI in all patients increased from 41 (36– 46) on admission to 43 (39–48) at discharge (P < 0.0001). Patients with PNI ≤ 40 had a lower event-free rate of death or rehospitalization with cardiovascular causes than those with PNI > 40 (log-rank P = 0.0001). When the PNI at discharge, age, sex, left ventricular ejection fraction, and Barthel index were evaluated in a multivariable Cox regression analysis, PNI ≤ 40 had an independent association with the death or rehospitalization with cardiovascular causes (hazard ratio, 2.14 [95% confidence interval, 1.14–4.01]; P = 0.0289).
Conclusions
One-third of FM patients with low PNI at discharge had a higher risk of mortality than those with high PNI in the chronic phase. This study provokes clinical insight into the phenotype of chronic inflammation in FM and optimal follow-up management with low PNI.
Nutritional management and practices in patients with bronchiolitis on non-invasive ventilation using a total face mask: an international survey in French network
Authors: Corbisier Tiphaine , Cousin Vladimir L , Polito Angelo , Bordessoule Alice 
Published: October 2024

Abstract

Purpose
Bronchiolitis is a major cause of respiratory failure in infants, necessitating non-invasive ventilation (NIV). While total face masks (TFM) are an alternative to nasal interfaces for NIV, they pose unique challenges for enteral feeding due to their design, which can limit airway access and increase the risk of complications. This study aimed to investigate the feeding practices of pediatric intensivists managing bronchiolitis patients using TFM for NIV.
Methods
A cross-sectional survey (Survey-Monkey® software (San Matteo, California, USA)) was conducted among pediatric intensivists in the Groupe Francophone de Réanimation et d'Urgences Pédiatrique (GFRUP) across four French-speaking countries. The survey, consisting of 11 multiple-choice questions, assessed clinical practices related to TFM use and enteral feeding, including initiation timing, feeding methods, and associated complications.
Results
From January 2024 to April 2024, 33 intensivists from 10 units and 4 countries (France, Switzerland, Belgium, Canada) answered the survey. All physicians used routinely TFM with 40% of them using it as a first-line NIV interface. Enteral feeding was commonly initiated within 6 hours of TFM initiation, with 72% of clinicians waiting for a stabilization period of 3 to 6 hours. The majority (85%) employed gastric feeding, with a low incidence of severe complications reported. Vomiting was the most frequent issue, while aspiration pneumonia was rare.
Conclusions
Despite the challenges associated with TFM, enteral feeding is widely practiced among pediatric intensivists, with a cautious approach to initiation and a low complication rate. These findings highlight the need for individualized feeding strategies and further research to optimize feeding practices in this population.
An Automatic Recognition of Indian Dish and Allergen Prediction Using DeepLearning
Authors: Kadam Viren , Pambhar Keval , Bachal Tarush , Agarwal Mihir , Thengade Anita 
Published: October 2024

Abstract

The research addresses the issue of image variability in practical settings by introducing a deep learning-based system for allergy prediction and Indian dish recognition. Food plays a big part in supporting a healthy lifestyle, which is becoming more and more popular globally. Recognizing the different types of food and the allergies that are in it is crucial. With the help of convolutional neural networks and visual transformers, the model can predict possible allergies and identify foods with accuracy, which is important for managing diet and raising awareness of allergens. Its uses are extensive in the food service, medical, and nutrition domains, providing workable answers for safer and better-informed nutritional selections in Indian food. Extensive analysis validates the model's effectiveness and potential influence on many sectors. In this study, various CNN architectures, including ResNet50, VGG16, VGG19, and a custom CNN, were employed for Indian Dish Recognition and Allergy Prediction. To enhance model accuracy, techniques such as image augmentation were integrated. While certain models showed promising results, reaching a maximum accuracy of 81%, others did not meet the desired expectations. To improve performance, Vision Transformers (ViTs) were employed, resulting in a remarkable accuracy of 92%.
Resilience as a Mediator of the Relationship between Perceived Social Support and Public Health Emergency-related Post-traumatic Growth among Medical staff
Authors: He Yi , Bai Xue , Dai Yuqian , Cai Ruiting , Yan Shijiao , Zou Li 
Published: October 2024

Abstract

Background
As central participants in Public Health Emergency (PHE), medical staffs may face positive changes, such as post-traumatic growth, while being traumatised. However, previous research remains deficient in factors influencing Post-Traumatic Growth (PTG). The aim of this paper is to examine how resilience mediates the relationship between perceived social support and PTG among medical staff.
Method
Using statistical descriptive and one-way analyses, we investigated the mediating effects of a cross-sectional study with 730 medical staff from a general hospital in Hubei Province, the epicenter of PHE in China, through Structural Equation Modelling(SEM).
Results
The mean PTG score among medical staff was 60.48 (SD = 24.49). The direct impact of perceived social support on PTG was significant (0.218, 95% CI [0.083, 0.361], P < 0.001), constituting 49.98% of the total effect. Moreover, the indirect impact of perceived social support on PTG via resilience was also significant (0.218, 95% CI [0.119, 0.320], P < 0.001), accounting for 50.02% of the total effect.
Conclusion
Our study demonstrated the positive impact of perceived social support on PTG among medical staff, with psychological resilience playing a mediating role. It suggests that interventions should focus on increasing perceived social support and resilience to foster positive psychological changes and improve the quality of healthcare services.
Donor selection in T-cell-replete haploidentical-related donor peripheral blood stem cell transplantation
Authors: Kanda Junya , Wada Fumiya , Iwasaki Makoto , Hirayama Masahiro , Kawamura Koji , Kaida Katsuji , Doki Noriko , Nakamae Hirohisa , Hasegawa Yuta , Fukuda Takahiro , Eto Tetsuya , Hiramoto Nobuhiro , Maruyama Yumiko , Nagafuji Koji , Ota Shuichi , Ishikawa Jun , Ando Toshihiko , Ichinohe Tatsuo , Atsuta Yoshiko , Nakasone Hideki 
Published: October 2024

Abstract

The effects of donor characteristics on outcomes after T-cell-replete (TCR) haploidentical-related donor peripheral blood stem cell transplantation (PBSCT) with post-transplant cyclophosphamide (PTCy) or low-dose antithymocyte globulin (ATG) remain unclear. We evaluated the impact in 1,677 patients who received a PTCy protocol (PTCy-haplo; n = 1,107) or low-dose ATG protocol (ATG-haplo; n = 570). A low CD34+ cell dose (<4 ×106/kg) was the only donor characteristic associated with worse overall survival (OS) after PTCy-haplo (adjusted hazard ratios [aHR] = 1.49, P = 0.008), whereas increased donor age by decade (aHR = 1.12, P = 0.008) and a large number of human leukocyte antigen mismatches (aHR = 1.46, P = 0.010) were associated with worse OS after ATG-haplo. Donor age increased the risk of grade II–IV acute graft-versus-host disease (GVHD) only after ATG-haplo (HR: 1.14, P = 0.018), whereas it increased the risk of grade III–IV acute GVHD both after PTCy-haplo (HR: 1.32, P = 0.009) and ATG-haplo (HR: 1.22, P = 0.006). Offspring donors had better relapse-free survival and GRFS than sibling donors after ATG-haplo. Our data suggest a comprehensive donor selection hierarchy after TCR haploidentical related-donor PBSCT with PTCy or low-dose ATG.
Porosity Prediction using Bagging Ensemble Machine Learning in CCUS Reservoirs. A Case Study: Darling Basin, Australia
Authors: Sandunil Kushan , Bennour Ziad , Sivakumar Saaveethya , Mahmud Hisham Ben , Giwelli Ausama 
Published: October 2024

Abstract

Machine learning (ML), a subset of artificial intelligence, has been utilised in many engineering fields, such as computer engineering, electrical engineering, civil engineering petroleum engineering. Bagging ensemble algorithms have been employed for parameter prediction, as they theoretically outperform traditional ML algorithms. Carbon dioxide capture and storage (CCS) is a strategy implemented to mitigate carbon dioxide emissions. A vital aspect of CCS assessment is determining carbon storage capacity, which estimates the amount of CO2 that can be stored in the subsurface. Porosity is a critical parameter in calculating this capacity. In this study, the applicability of regression friendly bagging ensemble ML models; random forest regression (RFR) and extra tree regression (ETR) to estimate porosity of a sandstone layer as part of a CCS program was investigated. RFR models were developed considering caliper log (CAL), gamma ray log (GR), neutron log (NPHI), photoelectric factor log (PE) and deep laterolog (LLD) input features and calculated porosity as targets. Moreover, four traditional (classical) ML models, multilayer perceptron (MLP), support vector regression (SVR), k-nearest neighbor (KNN) and decision tree regression (DTR), were developed to compare them with the bagging ensemble models. The results showed that the RFR model achieved a testing model R2 value of 0.9668, while ETR model achieved a resting model R2 value of 0.9569. The higher R2 value of the RFR model makes it a better choice for predicting porosity in CCS assessment projects. However, if computational time is a critical factor, ETR could be preferable, as it required only1/3 of the computational time that of the RFR model. Furthermore, when the performance of these models was compared with the four traditional ML models the two bagging ensembles distinctly outperformed the traditional models.
Who’s Using What? An Investigation of Drug Use Among First-Time Arrestees from 25 County Jails Across the United States in 2023
Authors: Schumacher Joseph E. , Ahsan Abdullah , Simpler Amber H. , Natoli Adam P. , Cain Bradley J. 
Published: October 2024

Abstract

Conducting research within a carceral health care context offers a unique view into the nature of drug use among arrestees with enormous potential to identify and prevent acute drug use consequences such as drug withdrawal and overdose. The purpose of this study was to characterize the nature and extent of drug use among contemporary first-time jail arrestees to inform the detection, treatment, and prevention of adverse consequences associated with drug use. This study utilized a naturalistic research design to collect de-identified urine drug screens (UDS), jail characteristics, and arrestee demographic variables from 25 jails across the United States in 2023 through a confidential data sharing agreement with NaphCare, Inc. using its proprietary electronic health record operating system. Descriptive statistics were used to detail the features of the dataset, Pearson’s chi-square tests of independence were performed to statistically analyze associations between UDS results and jail characteristics and arrestee demographics, and significant chi-square test results were further investigated by examining standardized residuals to clarify the nature and significance of within-group differences in proportions. Of the 43,553 UDS cases comprising the final sample (28.8% of total arrestees), 74.8% were positive for one or more drugs, and 25.2% of UDS cases were negative for all drugs. Positivity was 69.0% for cannabis, 54.8% for stimulants, 29.6% for opioids, and 12.4% for sedatives. Arrestees were positive for multiple drugs half the time, with combinations of cannabis, stimulants, and opioids most common. Several significant associations between drug use and both jail characteristics and arrestee demographics were found. Though drug use is not a recent phenomenon, the lethality potential of the drugs being used today is relatively new. The record-breaking number of deaths due to overdose and withdrawal has moved drug use beyond “public enemy number one” to a public health crisis, a crisis most evident among correctional populations. While we have the capacity to disrupt this crisis and prevent withdrawal-related fatalities with evidence-based clinical assessment tools and pharmacological agents, we need to further develop policies to allow arrestees to safely and securely convey all of their health care needs.
Real-world safety and efficacy of neoadjuvant docetaxel, cisplatin, and 5-fluorouracil therapy for locally advanced esophageal squamous cell carcinoma
Authors: Tamba Mikako , Osumi Hiroki , Ogura Mariko , Fukuoka Shota , Okamura Akihiko , Kanamori Jun , Imamura Yu , Takahari Daisuke , Yoshino Koichiro , Udagawa Shohei , Wakatsuki Takeru , Shinozaki Eiji , Watanabe Masayuki , Yamaguchi Kensei , Chin Keisho , Ooki Akira 
Published: October 2024

Abstract

Background
Neoadjuvant chemotherapy with docetaxel, cisplatin plus 5-FU (DCF) has become the new standard of care for locally advanced esophageal squamous cell carcinoma (ESCC). In a real-world setting, the efficacy, recurrence, and adverse events (AEs) remain unclear.
Methods
This retrospective cohort study included 86 patients who received neoadjuvant DCF followed by esophagectomy for resectable ESCC.
Results
Following neoadjuvant DCF treatment, 75 patients underwent R0 curative resection. At the median follow-up of 19.2 months, the median disease-free survival (DFS)/recurrence-free survival (RFS) was not yet reached, with estimated 3-year DFS/RFS rates of 65.2%, respectively. The incidence of primary tumor regression grading (TRG) grade 1a and pathological complete response (pCR) were 21.3% (16/75) and 14.7% (11/75), respectively. The estimated 3-year DFS/RFS rates were 93.8% for primary TRG grade 1a and 100% for pCR. Baseline elevated serum SCC-antigen levels were inversely associated with achieving primary TRG grade 1a or pCR. In 64 patients who did not achieve pCR, residual tumor cells in the lymph nodes (ypN; HR, 16.96; 95% CI, 2.11-136.12; P < 0.01) and Glasgow prognostic score (GPS; HR, 8.34; 95% CI, 1.73–40.31; P < 0.01) were independent predictors of shorter DFS/RFS. The most common grade 3–4 adverse events were neutropenia (61.6%) and febrile neutropenia (26.7%), which were not associated with clinicopathological factors.
Conclusions
Neoadjuvant DCF was effective and well-tolerated in real-world ESCC patients. Primary TRG grade 1a or pCR showed a favorable DFS/RFS, while positive ypN and GPS were independent risk factors for worse DFS/RFS.
Utilizing serum and urine metabolomics for diagnosing acute intra- abdominal infection in the early stage
Authors: Dong Zhenhua , Zhang Shaopeng , Zhang Hongwei , Yu Kai , Wang Daguang 
Published: October 2024

Abstract

Background:
Acute intra-abdominal infection (IAI), a normal disease of general surgery, is an important reason for patients’ death. However, owing to the defects of medical laboratory science and imaging tests, we can’t identify the patients with IAI timely. So, the metabolomics is applied to explore early biomarkers for IAI.
Methods:
A total of 30 IAI patients and 20 healthy volunteers are analyzed by liquid chromatography-mass spectrometry (LC-MS). First, we utilize total ion chromatography (TIC) and principal component analysis (PCA) to judge whether differential metabolites exist. Then student t test, partial least squares discriminant analysis (PLS-DA) and support vector machine (SVM) are performed to identify differential metabolites. We further use fisher discriminant analysis and hierarchical clustering analysis to observe the distinguishing effect of chosen metabolites. last, we select most eligible biomarkers based on receiver operating characteristic curve (ROC).
Results:
Finally, we identify 6 and 2 metabolites as biomarkers for IAI in serum and urine respectively.
Conclusions:
There are differential metabolites between healthy people and IAI patients. We could identify IAI patients more conveniently by detecting these biomarkers regularly.