bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological Description and Molecular Phylogeny of Two Species of Levicoleps (Ciliophora, Prostomatida), L. taehwae nov. spec. and L. biwae jejuensis nov. subspec., collected in Korea
Authors: Chen Xiangrui , Shazib Shahed Uddin Ahmed , Kim Ji Hye , Jang Seok Won , Shin Mann Kyoon 
Published: December 2015

AbstractTwo colepid ciliates, Levicoleps taehwae nov. spec. and L. biwae jejuensis nov. subspec., were collected from the brackish water of the Taehwa River and a small freshwater pond in Jeju Island, South Korea, respectively. Their living morphology, infraciliature, and small subunit (SSU) rRNA gene sequences were determined using standard methods. Barrel‐shaped L. taehwae nov. spec. is a small ciliate with an average size of 45 × 25 μm in vivo, about 15 ciliary rows each composed of 12 monokinetids and two perioral dikinetids, and two 20 μm‐long caudal cilia. The sequence length and GC content of the SSU rRNA gene are 1,669 bp, 44.5%. This novel species is similar in body size to Coleps hirtus, and has six armor tiers and hirtus‐type tier plates, and the same number of ciliary rows as C. hirtus; however, it can be distinguished from the latter by the absence of armor spines and its sequence similarity of SSU rRNA gene is about 92.8% which indicates that it is a distinct form. Levicoleps biwae jejuensis nov. subspec., is a medium colepid ciliate which has a barrel‐shaped body, about 22 somatic kineties and 16 transverse ciliary rows, three mini adoral organelles, and four 15 μm‐long caudal cilia. The sequence length and GC content of the SSU rRNA gene are 1,666 bp and 44.4%.
Prevalence of celiac disease in Asia: A systematic review and meta‐analysis
Authors: Singh Prashant , Arora Shubhangi , Singh Alka , Strand Tor A , Makharia Govind K 
Published: December 2015

AbstractBackground and AimCeliac disease (CD) is emerging in Asia. While a few population‐based studies from Asia have reported a prevalence of CD from 0.1% to 1.3%, the exact prevalence of CD in Asia is not known. We conducted a systematic review and meta‐analysis to estimate the prevalence of CD in Asia.MethodsOn search of literature, we found 1213 articles, of which 18 articles were included. Diagnosis of CD was based on European Society of Pediatric Gastroenterology, Hepatology and Nutrition guidelines.ResultsPooled sero‐prevalence of CD in Asia was 1.6% in 47 873 individuals based on positive anti‐tissue transglutaminase and/or anti‐endomysial antibodies. Pooled prevalence of biopsy proven CD in Asia was 0.5% in 43 955 individuals. The prevalence of CD among women was higher than in men (0.5% vs 0.4%, P = 0.04). The pooled prevalence of CD was 0.3% in Iran, 0.5% in Turkey, 0.6% in India, and 0.7% in Israel. The pooled prevalence of CD was significantly higher in Israel and India as compared with that in Iran.ConclusionsCeliac disease is not uncommon in Asia, and the sero‐prevalence and prevalence of CD in Asia are 1.6% and 0.5%, respectively. The prevalence of CD varies with gender and geographic location. There is a need for population‐based prevalence studies in many Asian countries to properly estimate the burden of CD in Asia.
Follicle‐stimulating hormone is associated with non‐alcoholic fatty liver disease in Chinese women over 55 years old
Authors: Wang Ningjian , Li Qin , Han Bing , Chen Yi , Zhu Chunfang , Chen Yingchao , Xia Fangzhen , Lu Meng , Meng Ying , Guo Yuyu , Ye Lin , Sui Chunhua , Kuang Lin , Lin Dongping , Lu Yingli 
Published: December 2015

AbstractBackground and AimObesity and diabetes are related to non‐alcoholic fatty liver disease (NAFLD). A reduction in follicle‐stimulating hormone (FSH) is associated with obesity and diabetes in postmenopausal women. Thus, we aim to investigate whether FSH is associated with NAFLD in women over 55 who were postmenopausal with a high probability.MethodsOur data were obtained from the 2014 Survey on Prevalence in East China for Metabolic Diseases and Risk Factors. A total of 1635 women at the age of 55–89 years were selected. The degrees of fatty liver were categorized into mild and moderate‐severe hepatic steatosis groups by ultrasonography. FSH and other sex hormones were measured by chemiluminescence.ResultsA total of 366 (22.4%) and 417 (25.5%) women had mild and moderate‐severe hepatic steatosis, respectively. FSH was negatively correlated with waist circumference, homeostasis model assessment of insulin resistance (HOMA‐IR), and other metabolic factors (all P < 0.05). After adjusting for age, estradiol, and total testosterone, increased quartiles of FSH were associated with significantly decreased odds ratios of mild and moderate‐severe groups (both P for trends <0.05). After further adjustment for waist circumference and HOMA‐IR, FSH was no longer associated with mild hepatic steatosis. The association of FSH with moderate‐severe hepatic steatosis was attenuated by waist circumference and HOMA‐IR but persisted in the fully adjusted model (P for trend <0.01).ConclusionFollicle‐stimulating hormone was negatively associated with NAFLD in women over 55 years old. Adiposity and insulin resistance explained most of the association of mild hepatic steatosis and partially explained the association of moderate‐severe hepatic steatosis with FSH.
Attenuated presenilin‐1 endoproteolysis enhances store‐operated calcium currents in neuronal cells
Authors: Ryazantseva Maria , Skobeleva Ksenia , Glushankova Lyubov , Kaznacheyeva Elena 
Published: December 2015

AbstractPresenilins have been reported to regulate calcium homeostasis in the endoplasmic reticulum, and dysregulation of intracellular calcium has been implicated in the pathogenesis of Alzheimer's disease (AD). Reduced endoproteolysis levels of presenilin‐1 (PS1) have been detected in postmortem brains of patients carrying familial Alzheimer's disease PS1 mutations. This study deals with the effect of attenuated endoproteolysis of PS1 on store‐operated calcium (SOC) entry in neuronal cells and mouse fibroblasts with double knockouts of PS1 and PS2. Significant enhancement of SOC channel activation has been detected by electrophysiological measurements in cells with reduced PS1 endoproteolysis. The increase in SOC entry was not accompanied by any changes in protein levels of channels subunits or stromal interaction molecule. These data are important for understanding the role of PS1 in AD, apart from its involvement in γ‐secretase cleavage of amyloid precursor protein into Aβ. Taking into account that most of familial AD‐connected mutations in PS1 are loss‐of‐function, the observed effects may well be general for familial AD.image
Reduced endoproteolysis levels of presenilin‐1 (PS1) have been detected in postmortem brains of patients carrying familial Alzheimer's disease PS1 mutations. Significant enhancement of SOC channel activation has been detected by electrophysiological measurements in cells with reduced PS1 endoproteolysis. The data obtained shed light on Alzheimer's disease pathogenesis and implicates to the future drugs development.
Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin
Authors: Volt Huayqui , García José A. , Doerrier Carolina , Díaz‐Casado María E. , Guerra‐Librero Ana , López Luis C. , Escames Germaine , Tresguerres Jesús A. , Acuña‐Castroviejo Darío 
Published: December 2015

AbstractThe connection between the innate immune system, clock genes, and mitochondrial bioenergetics was analyzed during aging and sepsis in mouse heart. Our results suggest that the sole NF‐κB activation does not explain the inflammatory process underlying aging; the former also triggers the NLRP3 inflammasome that enhances caspase‐1‐dependent maturation of IL‐1β. In this way, aged mice enter into a vicious cycle as IL‐1β further activates the NF‐κB/NLRP3 inflammasome link. The origin of NF‐κB activation was related to the age‐dependent Bmal1/Clock/RORα/Rev‐Erbα loop disruption, which lowers NAD+ levels, reducing the SIRT1 deacetylase ability to inactivate NF‐κB. Consequently, NF‐κB binding to DNA increases, raising the formation of proinflammatory mediators and inducing mitochondrial impairment. The cycle is then closed with the subsequent NLRP3 inflammasome activation. This paired contribution of the innate immune pathways serves as a catalyst to magnify the response to sepsis in aged compared with young mice. Melatonin administration blunted the septic response, reducing inflammation and oxidative stress, and enhancing mitochondrial function at the levels of nonseptic aged mice, but it did not counteract the age‐related inflammation. Together, our results suggest that, although with different strengths, chronoinflammaging constitutes the biochemical substrate of aging and sepsis, and identifies the NLRP3 inflammasome as a new molecular target for melatonin, providing a rationale for its use in NLRP3‐dependent diseases.
Glutathione‐dependent induction of local and systemic defense against oxidative stress by exogenous melatonin in cucumber (Cucumis sativus L.)
Authors: Li Hao , He Jie , Yang Xiaozhen , Li Xin , Luo Dan , Wei Chunhua , Ma Jianxiang , Zhang Yong , Yang Jianqiang , Zhang Xian 
Published: December 2015

AbstractMelatonin is involved in defending against oxidative stress caused by various environmental stresses in plants. In this study, the roles of exogenous melatonin in regulating local and systemic defense against photooxidative stress in cucumber (Cucumis sativus) and the involvement of redox signaling were examined. Foliar or rhizospheric treatment with melatonin enhanced tolerance to photooxidative stress in both melatonin‐treated leaves and untreated systemic leaves. Increased melatonin levels are capable of increasing glutathione (reduced glutathione [GSH]) redox status. Application of H2O2 and GSH also induced tolerance to photooxidative stress, while inhibition of H2O2 accumulation and GSH synthesis compromised melatonin‐induced local and systemic tolerance to photooxidative stress. H2O2 treatment increased the GSH/oxidized glutathione (GSSG) ratio, while inhibition of H2O2 accumulation prevented a melatonin‐induced increase in the GSH/GSSG ratio. Additionally, inhibition of GSH synthesis blocked H2O2‐induced photooxidative stress tolerance, whereas scavenging or inhibition of H2O2 production attenuated but did not abolish GSH‐induced tolerance to photooxidative stress. These results strongly suggest that exogenous melatonin is capable of inducing both local and systemic defense against photooxidative stress and melatonin‐enhanced GSH/GSSG ratio in a H2O2‐dependent manner is critical in the induction of tolerance.
Efficacy evaluation of clonazepam for symptom remission in burning mouth syndrome: a meta‐analysis
Authors: Cui Y , Xu H , Chen FM , Liu JL , Jiang L , Zhou Y , Chen QM 
Published: December 2015

ObjectivesClonazepam has been used in the treatment of burning mouth syndrome (BMS) for several decades. We conducted a meta‐analysis to investigate the efficacy of clonazepam in the treatment of BMS.MethodsWe conducted a search of the PubMed, MEDLINE, EMBASE, Web of Science (TS), and the Cochrane Library databases for relevant studies that met our eligibility criteria (up to September 22, 2015). Statistical analyses were conducted using RevMan 5.2 and STATA 11.0 software.ResultsThree randomized controlled trials (RCTs) and two high‐quality case–control studies involving 195 BMS patients were selected for this study. Our results show that clonazepam can reduce the oral pain sensation in patients with BMS (WMD: −3.72, 95% CI: −4.57, −2.86; P < 0.05; for all five studies). A positive therapeutic effect was demonstrated for both short‐term (≤10 weeks) application (WMD: −1.44, 95% CI: −2.06, −0.82; P < 0.05) and long‐term (>10 weeks) application (WMD: −4.50, 95% CI: −4.98, −4.03; P < 0.05). Both topical (WMD: −1.50, 95% CI: −2.14, −0.85; P < 0.05) and systemic (WMD: −3.81, 95% CI: −4.63, −2.98; P < 0.05) administration of clonazepam were confirmed to be effective.ConclusionClonazepam is effective in inducing symptom remission in patients with BMS.
Psychological disorders and oral lichen planus: matched case–control study and literature review
Authors: Pippi R , Romeo U , Santoro M , Del Vecchio A , Scully C , Petti S 
Published: December 2015

ObjectiveOral lichen planus (OLP) may be linked to psychological disorders. This study investigated psychological factors associated with OLP.MethodsA case–control study with incident OLP case patients and age–gender–socio‐economic status‐matched controls, recruited from among relatives, accompanying persons, and departmental staff, investigated psychological traits using the Psychological General Well‐Being Index‐Short form. Common factor analysis was used to generate a set of psychological dimensions. The association between these dimensions and OLP adjusted for confounders (education, number of lifetime sexual partners, drinking–smoking) and interactions was assessed through conditional logistic regression and odds ratios (OR) were estimated.ResultsA total of 67 case–control pairs were recruited. Psychological dimensions generated were: dimension‐1 (anxiety, low vitality), dimension‐2 (negative well‐being, low vitality), dimension‐3 (depressed mood, low self‐control). The ORs for OLP were, dimension‐1, 1.0 (95% confidence interval ‐95CI, 0.3–2.6); dimension‐2, 0.5 (95CI, 0.2–1.2); dimension‐3, 4.8 (95CI, 1.8–12.9). Dimension‐3 was highly associated with mild, but not associated with severe, OLP. Literature searching provided 21 studies, with anxiety and depression principally associated with OLP.ConclusionsDepressed mood and low self‐control were highly associated with OLP, particularly the reticular–papular forms. These traits could have a causative role in OLP development‐progression, but further investigations are necessary.
Patient quality of life following induction of oral immunotherapy for food allergy
Authors: Epstein Rigbi Na'ama , Katz Yitzhak , Goldberg Michael R. , Levy Michael B. , Nachshon Liat , Elizur Arnon 
Published: December 2015

AbstractBackgroundPatient quality of life improves following successful completion of oral immunotherapy (OIT), but the process itself might have undesirable effects. We aimed to evaluate patient quality of life following OIT initial induction.MethodsThe Hebrew version of the Food Allergy Quality of Life Questionnaire‐Parental Form (FAQLQ‐PF) was validated and administered to the parents of children following the first week of OIT for food allergy (n = 119). Patient demographics and clinical history as well as the course of initial induction week were reviewed.ResultsPre‐OIT severity of food allergy, defined as severity of reactions due to accidental exposure to the allergenic food (anaphylactic reactions, p = 0.017; epinephrine use, p = 0.049; emergency room referrals p = 0.003; and hospital admissions, p = 0.015) and a lower number of tolerated doses during initial induction, reflective of a lower maximal tolerated dose for the different allergens (p = 0.011) were associated with worse total FAQLQ‐PF scores. The number of tolerated doses during induction and pre‐OIT emergency room referrals remained significantly associated with worse total score of the FAQLQ‐PF on multivariate analysis (p = 0.016 and p = 0.005, respectively). The correlation between the number of tolerated doses and quality of life scores was moderate–strong primarily in children aged 6–12 years (Total score, r = −0.41, p = 0.001; Emotional Impact r = −0.42, p = 0.001; Food Anxiety, r = −0.38, p = 0.002; Social and Dietary Limitations, r = −0.33, p = 0.009).ConclusionsPre‐OIT reaction severity affects quality of life in both preschool and school‐aged food‐allergic children. In contrast, a lower maximal tolerated dose during OIT induction is associated with worse indices of quality of life primarily in children aged 6–12 years.
Four receptor‐like cytoplasmic kinases regulate development and immunity in rice
Authors: Zhou Xiaogang , Wang Jing , Peng Chunfang , Zhu Xiaobo , Yin Junjie , Li Weitao , He Min , Wang Jichun , Chern Mawsheng , Yuan Can , Wu Wenguan , Ma Weiwei , Qin Peng , Ma Bintian , Wu Xianjun , Li Shigui , Ronald Pamela , Chen Xuewei 
Published: December 2015

AbstractReceptor‐like cytoplasmic kinases (RLCKs) represent a large family of proteins in plants. However, few RLCKs have been well characterized. Here, we report the functional characterization of four rice RLCKs – OsRLCK57, OsRLCK107, OsRLCK118 and OsRLCK176 from subfamily VII. These OsRLCKs interact with the rice brassinosteroid receptor, OsBRI1 in yeast cell, but not the XA21 immune receptor. Transgenic lines silenced for each of these genes have enlarged leaf angles and are hypersensitive to brassinolide treatment compared to wild type rice. Transgenic plants silenced for OsRLCK57 had significantly fewer tillers and reduced panicle secondary branching, and lines silenced for OsRLCK107 and OsRLCK118 produce fewer seeds. Silencing of these genes decreased Xa21 gene expression and compromised XA21‐mediated immunity to Xanthomonas oryzae pv. oryzae. Our study demonstrates that these OsRLCKs negatively regulate BR signalling, while positively regulating immune responses by contributing to the expression of the immune receptor XA21.
Incomplete Kawasaki disease in a 12‐month‐old girl presenting with cardiac murmur and iron deficiency anemia
Authors: Choi Yunjung , Eun Lucy Youngmin , Oh Seung Hwan 
Published: December 2015

AbstractKawasaki disease (KD) is an acute necrotizing vasculitis that occurs in children <5 years of age. The cause of KD remains unknown, but various complications, including dilatation of the coronary arteries, can occur. Coronary artery aneurysm or ectasia are the most important complications of KD. Children with suspected KD who do not fulfill the diagnostic criteria may have incomplete KD. Given that incomplete KD is associated with delayed diagnosis and treatment, children with incomplete KD have a high risk of cardiovascular complications. Meanwhile, iron deficiency anemia (IDA) is one of the most prevalent micronutrient deficiencies in the world. Children with IDA are prone to infection and inflammation. We report the case of a 12‐month‐old girl with incomplete KD who presented with cardiac murmur and severe IDA.
Neurological damage disrupts normal sex differences in psychophysiological responsiveness to music
Authors: Belfi Amy M. , Chen Kuan‐Hua , Schneider Brett , Tranel Daniel 
Published: December 2015

AbstractMen and women often display different physiological responses to emotional stimuli, and these responses can be affected by brain damage. Here, we investigated how brain damage differentially affects electrodermal responses based on sex. We studied neurologically normal, healthy adults and a sample of neurological patients. Participants listened to music, an emotional stimulus that reliably elicits skin conductance responses (SCRs). Electrodermal activity was recorded while participants listened to musical clips. When analyzing the data without regard to sex, there were no differences between healthy and brain‐damaged participants in their SCRs. However, we found a significant interaction between brain injury status and sex. For men, brain damage significantly reduced SCRs. For women, there were no differences between brain‐damaged participants and neurologically healthy participants. These findings illustrate the importance of including demographic variables, such as sex, when investigating brain‐behavior relationships with a psychophysiological dependent variable.
Ethnic/racial differences in the association between social support and levels of C‐reactive proteins in the North Texas Heart Study
Authors: Uchino Bert N. , Ruiz John M. , Smith Timothy W. , Smyth Joshua M. , Taylor Daniel J. , Allison Matthew , Ahn Chul 
Published: December 2015

AbstractPerceived social support has been reliably related to lower rates of morbidity and mortality. However, studies modeling C‐reactive protein (CRP) as an important biological pathway linking social support to health have produced inconsistent results. Given purported ethnic/racial differences in sensitivity to social resources, the present study tested if ethnicity/race moderated the link between perceived support and CRP in a diverse community sample of 300 participants from the North Texas Heart Study. Consistent with prior research, there was no overall link between social support and CRP levels. However, the association between social support and high sensitivity (hs)‐CRP levels was moderated by ethnicity/race as perceived support predicted lower hs‐CRP levels primarily in African Americans. These results suggest the importance of considering how ethnicity/race may inform models on the complex biological mechanisms linking social support to health.
The impact of maternal depression and overcrowded housing on associations between autonomic nervous system reactivity and externalizing behavior problems in vulnerable Latino children
Authors: Waters Sara F. , Boyce W. Thomas , Eskenazi Brenda , Alkon Abbey 
Published: December 2015

AbstractThe study of autonomic nervous system responses and contextual factors has shed light on the development of children's negative outcomes, but the majority of these studies have not focused on minority populations living under adversity. To address these gaps, the current longitudinal study included a sample of poor, immigrant Latino families to examine whether associations between children's autonomic nervous system reactivity at 6 months and their externalizing behavior problems at 7 years of age were moderated by two risk factors associated with poverty: the interpersonal factor of chronic maternal depression and the environmental factor of chronic overcrowded housing. Multiple linear regression (N = 99) revealed that children who exhibited less parasympathetic nervous system withdrawal in response to challenge during infancy had more externalizing problems during childhood only if they had mothers who experienced chronic depression. Children who exhibited greater sympathetic nervous system reactivity during infancy had the lowest levels of externalizing problems during childhood only if they had mothers who chronic depression. Chronic overcrowded housing did not moderate associations between physiological reactivity and level of externalizing problems. These findings extend our understanding of the interaction of physiology and context on child outcomes to the understudied population of impoverished Latino families.
Cultural shaping of neural responses: Feedback‐related potentials vary with self‐construal and face priming
Authors: Hitokoto Hidefumi , Glazer James , Kitayama Shinobu 
Published: December 2015

AbstractPrevious work shows that when an image of a face is presented immediately prior to each trial of a speeded cognitive task (face‐priming), the error‐related negativity (ERN) is upregulated for Asians, but it is downregulated for Caucasians. These findings are consistent with the hypothesis that images of “generalized other” vary cross‐culturally such that they evoke anxiety for Asians, whereas they serve as safety cues for Caucasians. Here, we tested whether the cross‐cultural variation in the face‐priming effect would be observed in a gambling paradigm. Caucasian Americans, Asian Americans, and Asian sojourners were exposed to a brief flash of a schematic face during a gamble. For Asian Americans, face‐priming resulted in significant increases of both negative‐going deflection of ERP upon negative feedback (feedback‐related negativity [FRN]) and positive‐going deflection of ERP upon positive feedback (feedback‐related positivity [FRP]). For Caucasian Americans, face‐priming showed a significant reversal, decreasing both FRN and FRP. The cultural difference in the face‐priming effect in FRN and FRP was partially mediated by interdependent self‐construal. Curiously, Asian sojourners showed a pattern similar to the one for Caucasian Americans. Our findings suggest that culture shapes neural pathways in both systematic and highly dynamic fashion.