bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fruit firmness, superficial damage, and location modulate infestation by Drosophila suzukii and Zaprionus indianus: the case of guava in Veracruz, Mexico
Authors: Lasa Rodrigo , Tadeo Eduardo , Dinorín Luis A. , Lima Itzel , Williams Trevor 
Published: December 2016

AbstractThe exotic pestiferous flies Drosophila suzukii (Matsumura) and Zaprionus indianus Gupta (Diptera: Drosophilidae) were recently identified in traps used for monitoring tephritid pests of guava, Psidium guajava L. (Myrtaceae), in Veracruz, Mexico. To determine whether both drosophilids were infesting guava, a previously unreported host, samples were taken from fruits on trees and fallen fruits on the ground. Overall, 74 and 36% of visually intact fruits attached to the tree were infested by D. suzukii and Z. indianus, respectively. Under laboratory conditions, small artificial punctures on the surface of ripe guavas did not result in increased oviposition by D. suzukii compared to undamaged fruit, whereas Z. indianus almost completely avoided oviposition, or were not capable of developing in fruit. Females of D. suzukii were capable of ovipositing in early ripe guavas in laboratory tests (23% of fruits were used for oviposition), although a high penetration force is required to pierce fruit (mean ± SEM = 89.0 ± 3.0 cN). Fully ripe and overripe guavas were softer (52.2–53.5 cN penetration force) and were more frequently infested (ca. 60% infestation). Numbers of females that developed in guavas were not influenced by ripeness/firmness, whereas male development was reduced in early ripe fruit compared to ripe and overripe fruit. In laboratory choice experiments with crushed fruits, D. suzukii adults were equally attracted to guava and blueberry, independent of gender and age. However, raspberry was more attractive than guava. This study demonstrates that D. suzukii is attracted to guava, is capable of ovipositing in fruit and, under field conditions, is more abundant in fruits still attached to the tree compared to fallen fruit that remain intact. In contrast, Z. indianus was not capable of developing in intact guavas and, although present in fruits attached to the tree, was most abundant in fallen damaged fruits.
Flow cytometry minimal residual disease after allogeneic transplant for chronic lymphocytic leukemia
Authors: Algrin Caroline , Golmard Jean‐Louis , Michallet Mauricette , Reman Oumedaly , Huynh Anne , Perrot Aurore , Sirvent Anne , Plesa Adriana , Salaun Véronique , Béné Marie‐Christine , Bories Dominique , Tournilhac Olivier , Merle‐Béral Hélène , Leblond Véronique , Le Garff‐Tavernier Magali , Dhedin Nathalie 
Published: December 2016

AbstractObjectivesThis study investigates whether achieving complete remission (CR) with undetectable minimal residual disease (MRD) after allogeneic stem cell transplantation (allo‐SCT) for chronic lymphocytic leukemia (CLL) affects outcome.MethodsWe retrospectively studied 46 patients transplanted for CLL and evaluated for post‐transplant MRD by flow cytometry.ResultsAt transplant time, 43% of the patients were in CR, including one with undetectable MRD, 46% were in partial response, and 11% had refractory disease. After transplant, 61% of the patients achieved CR with undetectable MRD status. By multivariate analysis, reaching CR with undetectable MRD 12 months after transplant was the only factor associated with better progression‐free survival (P = 0.02) and attaining undetectable MRD, independently of the time of negativity, was the only factor that correlated with better overall survival (P = 0.04).ConclusionThus, achieving undetectable MRD status after allo‐SCT for CLL is a major goal to improve post‐transplant outcome.
Pretransplant FDG‐PET in aggressive non‐Hodgkin lymphoma: systematic review and meta‐analysis
Authors: Adams Hugo J. A. , Kwee Thomas C. 
Published: December 2016

AbstractThis study aimed to systematically review and meta‐analyze the value of pretransplant FDG‐PET in predicting outcome after autologous stem cell transplantation in aggressive non‐Hodgkin lymphoma. MEDLINE was systematically searched; included studies were methodologically assessed and meta‐analyzed, when possible. Overall methodological quality of included studies (n = 11) was poor, with moderate risk of bias in the domains of study participation (n = 7) and prognostic factor measurement (n = 7), and high risk of bias in the domains of outcome measurement (n = 10), and study confounding (n = 11). In all aggressive non‐Hodgkin lymphomas, pooled sensitivity and specificity were 54.0% and 73.1% in predicting treatment failure, and 54.5% and 68.7% in predicting death. Because of interstudy heterogeneity, additional subgroup analyses were performed. In newly diagnosed aggressive non‐Hodgkin lymphoma, pooled sensitivity and specificity were 20.0% and 70.0% in predicting treatment failure, and 8.3% % and 30.5% in predicting death. In refractory/relapsed aggressive non‐Hodgkin lymphoma, pooled sensitivity and specificity were 68.1% and 72.1% in predicting treatment failure, and 77.3% and 69.6% in predicting death. At present, pretransplant FDG‐PET cannot be recommended in aggressive non‐Hodgkin lymphoma, because available studies suffer from major methodological flaws, and reported prognostic estimates are low (i.e., poor in newly diagnosed and moderate in refractory/relapsed aggressive non‐Hodgkin lymphoma).
Progression of subcortical atrophy in mild Parkinson's disease and its impact on cognition
Authors: Foo H. , Mak E. , Yong T. T. , Wen M. C. , Chander R. J. , Au W. L. , Sitoh Y. Y. , Tan L. C. S. , Kandiah N. 
Published: December 2016

Background and purposeMild cognitive impairment (MCI) is associated with pronounced grey matter atrophy in various brain regions. However, the association between atrophy patterns and progression from no cognitive impairment (NCI) to Parkinson's disease (PD)‐MCI is not clearly known. We investigated the pattern and progression of atrophy in subcortical structures and its impact on cognition in patients with mild PD.MethodsSixty‐five patients with mild PD with baseline and longitudinal clinical and neuropsychological assessments, and structural magnetic resonance imaging scans were studied. Movement Disorder Society Task Force criteria were used to classify patients with PD into PD‐NCI (n = 54) and PD‐MCI (n = 11). Based on progression over time, those who remained without cognitive impairment were classified as PD‐stable (n = 42) and those who converted to MCI over 18 months were classified as PD‐converters (n = 12). FreeSurfer was used to measure cortical thickness and subcortical volumes at baseline and follow‐up.ResultsParkinson's disease‐MCI showed baseline thalamus atrophy and progressive atrophy in the thalamus, caudate, presubiculum, cornu ammonis 1 and 2–3, and significant memory and executive dysfunction compared with PD‐NCI. PD‐converters had greater accumbens atrophy at baseline and progressive atrophy in the thalamus, caudate and accumbens with dysfunctions in memory and executive domains.ConclusionsProgression of cognitive impairment in non‐demented PD is associated with a specific pattern of subcortical atrophy. Findings from this study will allow future studies to investigate in the role of subcortical structures as a biomarker for PD dementia.
Development of ZrO2‐MgO nanocomposite powders by the modified sol‐gel method
Authors: Davar Fatemeh , Shayan Nasrin , Hojjati‐Najafabadi Akbar , Sabaghi Vahid , Hasani Saeed 
Published: December 2016

AbstractThe ZrO2‐MgO nanocomposites were synthesized using a new sol‐gel method with sucrose and tartaric acid as a gel agent. The samples were characterized by thermal analysis (TG/DTA), X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), field emission scanning electron microscopy (FESEM), energy‐dispersive X‐ray mapping (EDX mapping), and Ultraviolet‐visible spectroscopy (UV‐vis). The results showed that the cubic phase of ZrO2‐MgO was formed in the presence of both gel agents. The average particle size of the samples synthesized with sucrose was lower (30 nm) than that of tartaric acid (50 nm). Finally, the formation mechanism and the optical properties of zirconia‐magnesia have been discussed.
Determination of silicon carbide fiber electrical resistivity at elevated temperature
Authors: Smith Craig , Morscher Greg 
Published: December 2016

AbstractThe resistance of Sylramic‐iBN and Hi‐Nicalon SiC fiber tows was measured at elevated temperature in air. Resistivity could not be directly measured, since the fibers passed through a furnace with varying temperature along the length. The resistivity of the isothermal section of the fiber tow was modeled by a series circuit of finite elements. Existing data for Hi‐Nicalon resistivity vs temperature was used to verify the model and then extend it to Sylramic‐iBN, for which there is no literature data readily available. The model matched experimental values with low overall error (<±14%). Fiber resistivity decreased by more than two orders of magnitude when heating from 25°C to 1400°C. Sylramic‐iBN tow resistance was also measured during a 500 hour hold at 1315°C. The resistance increased by more than 140% during heat treatment. The resistance change correlated well with the decrease in SiC fiber diameter that resulted from oxidation.
Synthesis of ultrafine WC‐Co composite powders under hydrogen atmosphere with in situ carbon via a one‐step reduction‐carbonization process
Authors: Yang Qiumin , Yang Jiangao , Yang Hailin , Chen Hao , Su Wei , Ruan Jianming 
Published: December 2016

AbstractAn inexpensive and facile direct method to synthesis ultrafine WC‐Co composite powders was proposed employing soluble starch as an in situ carbon source in a H2 atmosphere via a one‐step reduction‐carbonization process. Influences of processing factors, such as temperature, H2 flow rate, and reaction time have been investigated. The results revealed that the system of synthesis process was dynamic in nature where temperature, H2 flow rate, and reaction time had a suitable value to achieve the desired product phase. Mainly due to the gas reaction and homogeneous in situ carbon, the synthesizing temperature and reaction time were greatly lower than the conventional method. Lowering the reaction temperature and increasing the reaction rate would lead to finer WC‐Co composite powders. Ultrafine WC‐Co composite powders with almost no unwanted phases were obtained under the H2 flow rate of 0.75 m3/h at 950°C for 0.5 hour and the average particle size was 155 nm with good dispersion. Furthermore, the mechanism for the phase transformation was discussed in this study as well.
Temporal cross‐correlation between influenza‐like illnesses and invasive pneumococcal disease in The Netherlands
Authors: Hendriks Wilke , Boshuizen Hendriek , Dekkers Arnold , Knol Mirjam , Donker Ge A. , van der Ende Arie , Korthals Altes Hester 
Published: December 2016

BackgroundWhile the burden of community‐acquired pneumonia and invasive pneumococcal disease (IPD) is still considerable, there is little insight in the factors contributing to disease. Previous research on the lagged relationship between respiratory viruses and pneumococcal disease incidence is inconclusive, and studies correcting for temporal autocorrelation are lacking.ObjectivesTo investigate the temporal relation between influenza‐like illnesses (ILI) and IPD, correcting for temporal autocorrelation.MethodsWeekly counts of ILI were obtained from the Sentinel Practices of NIVEL Primary Care Database. IPD data were collected from the Dutch laboratory‐based surveillance system for bacterial meningitis from 2004 to 2014. We analysed the correlation between time series, pre‐whitening the dependent time series with the best‐fit seasonal autoregressive integrated moving average (SARIMA) model to the independent time series. We performed cross‐correlations between ILI and IPD incidences, and the (pre‐whitened) residuals, in the overall population and in the elderly.ResultsWe found significant cross‐correlations between ILI and IPD incidences peaking at lags ‐3 overall and at 1 week in the 65+ population. However, after pre‐whitening, no cross‐correlations were apparent in either population group.ConclusionOur study suggests that ILI occurrence does not seem to be the major driver of IPD incidence in The Netherlands.
Frequency and intensity of symptoms and treatment interventions in hospitalized older palliative cancer patients: a multicentre cross‐sectional study
Authors: Van Lancker Aurélie , Beeckman Dimitri , Van Den Noortgate Nele , Verhaeghe Sofie , Van Hecke Ann 
Published: December 2016

AbstractAimTo increase the knowledge of the frequency and intensity of symptoms and the treatment interventions in older palliative cancer patients.BackgroundResearch on symptoms and the treatment modalities in older palliative cancer patients is scarce. Insight into these aspects is needed to enable healthcare professionals to alleviate the burden.DesignA cross‐sectional study.MethodsFour hundred hospitalized older palliative cancer patients participated in the study between March 2013 ‐ February 2015. Two validated instruments were used to assess 40 symptoms in multiple domains and collect data on the treatment modalities in older palliative cancer patients.ResultsPatients reported on average approximately 14 symptoms. Dry mouth, physical fatigue, lack of energy, lack of appetite and difficulty moving outside were the most prevalent. Psychological pain, psychological fatigue, lack of willpower, lack of energy and physical fatigue were reported as intensive. On average, 5·15 disciplines were consulted per patient. Few patients were referred to a palliative support team, spiritual consultant or psychologist. Patients received a variety of interventions to increase life expectancy and alleviate symptoms and the side effects of treatment. The occurrence of symptoms was associated with different clinical and treatment variables such as having a geriatric risk profile.ConclusionsOlder patients receiving palliative cancer care are confronted with multiple symptoms. Psychological symptoms are more often reported as intensive. Greater attention should be given to the early referral of patients to palliative care teams, assessment and management of multiple symptoms, particularly psychological symptoms.
Using rapid reviews: an example from a study conducted to inform policy‐making
Authors: O'Leary Denise F. , Casey Mary , O'Connor Laserina , Stokes Diarmuid , Fealy Gerard M. , O'Brien Denise , Smith Rita , McNamara Martin S. , Egan Claire 
Published: December 2016

AbstractAimA discussion of the potential use of rapid review approaches in nursing and midwifery research which presents a worked example from a study conducted to inform policy decision‐making.BackgroundRapid reviews, which can be defined as outputs of a knowledge synthesis approach that involves modifying or omitting elements of a systematic review process due to limited time or resources, are becoming increasingly popular in health research. This paper provides guidance on how a rapid review can be undertaken and discusses the strengths and challenges of the approach.DesignData from a rapid review of the literature undertaken in 2015 is used as a worked example to highlight one method of undertaking a rapid review.Implications for nursingSeeking evidence to inform health policy‐making or evidence based practice is a process that can be limited by time constraints, making it difficult to conduct comprehensive systematic reviews. Rapid reviews provide a solution as they are a systematic method of synthesizing evidence quickly.ConclusionsThere is no single best way to conduct a rapid review but researchers can ensure they are adhering to best practice by being systematic, having subject and methodological expertise on the review team, reporting the details of the approach they took, highlighting the limitations of the approach, engaging in good evidence synthesis and communicating regularly with end users, other team members and experts.
Rapid realist review of the evidence: achieving lasting change when mental health rehabilitation staff undertake recovery‐oriented training
Authors: Gee Melanie , Bhanbhro Sadiq , Cook Sarah , Killaspy Helen 
Published: December 2016

AbstractAimThe aim of this study was to identify the factors contributing to lasting change in practice following a recovery‐based training intervention for inpatient mental health rehabilitation staff.BackgroundStaff training may help nurses and other staff groups in inpatient mental health rehabilitative settings to increase their recovery‐oriented practice. There are no published reviews on the effectiveness of such training and few long‐term evaluations. This review informed a realist evaluation of a specific intervention (GetREAL).DesignRapid realist review methodology was used to generate and prioritize programme theories.Data sourcesASSIA, CINAHL, Cochrane Library, Medline, PsycINFO, Scopus, Web of Science and grey literature searches were performed in September 2014–March 2015 with no date restrictions. Stakeholders suggested further documents. GetREAL project documentation was consulted.Review methodsProgramme theory development took place iteratively with literature identification. Stakeholders validated and prioritized emerging programme theories and the prioritized theories were refined using literature case studies.ResultsFifty‐one relevant documents fed into 49 programme theories articulating seven mechanisms for lasting change. Prioritized mechanisms were: staff receptiveness to change; and staff feeling encouraged, motivated and supported by colleagues and management to change. Seven programme theories were prioritized and refined using data from four case studies.ConclusionLasting change can be facilitated by collaborative action planning, regular collaborative meetings, appointing a change agent, explicit management endorsement and prioritization and modifying organizational structures. Conversely, a challenging organizational climate, or a prevalence of ‘change fatigue’, may block change. Pre‐intervention exploration may help identify any potential barriers to embedding recovery in the organizational culture.
Development and validation of the pro‐environmental behaviour scale for women's health
Authors: Kim HyunKyoung 
Published: December 2016

AbstractAimThis study was aimed to develop and test the Pro‐environmental Behavior Scale for Women's Health.BackgroundWomen adopt sustainable behaviours and alter their life styles to protect the environment and their health from environmental pollution. The conceptual framework of pro‐environmental behaviours was based on Rogers’ protection motivation theory and Weinstein's precaution adoption process model.DesignThe cross‐sectional design was used for instrument development.MethodThe instrument development process consisted of a literature review, personal depth interviews and focus group interviews. The sample comprised 356 adult women recruited in April–May 2012 in South Korea using quota sampling. For construct validity, exploratory factor analysis was conducted to examine the factor structure, after which convergent and discriminant validity and known‐group comparisons were tested.ResultsPrincipal component analysis yielded 17 items with four factors, including ‘women's health protection,’ ‘chemical exposure prevention,’ ‘alternative consumption,’ and ‘community‐oriented behaviour’. The Cronbach's α was 0·81. Convergent and discriminant validity were supported by performing correlations with other environmental‐health and health‐behaviour measures.ConclusionNursing professionals can reliably use the instrument to assess women's behaviours, which protect their health and the environment.
Annual Research Review: Digital health interventions for children and young people with mental health problems – a systematic and meta‐review
Authors: Hollis Chris , Falconer Caroline J. , Martin Jennifer L. , Whittington Craig , Stockton Sarah , Glazebrook Cris , Davies E. Bethan 
Published: December 2016

BackgroundDigital health interventions (DHIs), including computer‐assisted therapy, smartphone apps and wearable technologies, are heralded as having enormous potential to improve uptake and accessibility, efficiency, clinical effectiveness and personalisation of mental health interventions. It is generally assumed that DHIs will be preferred by children and young people (CYP) given their ubiquitous digital activity. However, it remains uncertain whether: DHIs for CYP are clinically and cost‐effective, CYP prefer DHIs to traditional services, DHIs widen access and how they should be evaluated and adopted by mental health services. This review evaluates the evidence‐base for DHIs and considers the key research questions and approaches to evaluation and implementation.MethodsWe conducted a meta‐review of scoping, narrative, systematic or meta‐analytical reviews investigating the effectiveness of DHIs for mental health problems in CYP. We also updated a systematic review of randomised controlled trials (RCTs) of DHIs for CYP published in the last 3 years.ResultsTwenty‐one reviews were included in the meta‐review. The findings provide some support for the clinical benefit of DHIs, particularly computerised cognitive behavioural therapy (cCBT), for depression and anxiety in adolescents and young adults. The systematic review identified 30 new RCTs evaluating DHIs for attention deficit/hyperactivity disorder (ADHD), autism, anxiety, depression, psychosis, eating disorders and PTSD. The benefits of DHIs in managing ADHD, autism, psychosis and eating disorders are uncertain, and evidence is lacking regarding the cost‐effectiveness of DHIs.ConclusionsKey methodological limitations make it difficult to draw definitive conclusions from existing clinical trials of DHIs. Issues include variable uptake and engagement with DHIs, lack of an agreed typology/taxonomy for DHIs, small sample sizes, lack of blinded outcome assessment, combining different comparators, short‐term follow‐up and poor specification of the level of human support. Research and practice recommendations are presented that address the key research questions and methodological issues for the evaluation and clinical implementation of DHIs for CYP.