bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meaningful Use of an Electronic Personal Health Record (ePHR) among Pediatric Cancer Survivors
Authors: Williamson Rebecca S , Cherven Brooke O , Marchak Jordan Gilleland , Edwards Paula , Palgon Michael , Escoffery Cam , Meacham Lillian R , Mertens Ann C 
Published: March 2017

Summary
Background and Objectivs: Survivors of pediatric and adolescent cancer are at an increased risk of chronic and debilitating health conditions and require life-long specialized care. Stand-alone electronic personal health records (ePHRs) may aid their self-management. This analysis characterizes young adult survivors and parents who meaningfully use an ePHR, Cancer SurvivorLinkTM, designed for survivors of pediatric and adolescent cancer.
Methods: This was a retrospective observational study of patients seen at a pediatric survivor clinic for annual survivor care. Young adult survivors and/or parent proxies for survivors <18 years old who completed ePHR registration prior to their appointment or within 90 days were classified as registrants. Registrants who uploaded or downloaded a document and/or shared their record were classified as meaningful users.
Results: Overall, 23.7% (148/624) of survivors/parents registered and 38% of registrants used SurvivorLink meaningfully. Young adult registrants who transferred to adult care during the study period were more likely to be meaningful users (aOR: 2.6 (95% CI: 1.1, 6.1)) and used the ePHR twice as frequently as those who continued to receive care in our institution’s pediatric survivor clinic. Among survivors who continued to receive care at our institution, being a registrant was associated with having an annual follow-up visit (aOR: 2.6 (95% CI: 1.2, 5.8)).
Conclusions: While ePHRs may not be utilized by all survivors, SurvivorLink is a resource for a subset and may serve as an important bridge for patients who transfer their care. Using SurvivorLink was also associated with receiving recommended annual survivor care.
Geweld tegen politieambtenaren
Authors: Stad Danaé , Timmer Jaap 
Published: March 2017

Violence against police officers: perception and justifications of suspects
This paper tries to answer the question why defendants use violence against police officers and whether, and if so how, they construct justifications for their own behavior. The study consists of an analysis of the situational aspects of violence against police officers and the characteristics of suspects. In addition, some suspects were interviewed about the incident in which they were involved. They were asked what their perception of the situation was, and what the background of the violence was. They were also asked for their opinion on the image of the police in general, and for their knowledge and perception of the relevant laws and regulations. The conclusion is that the motives for violence against a police officer lie in their belief that all men, police officer or not, are equal and should be treated with respect. Suspects feel treated unfairly and disrespectfully by police officers. Suspects feel that in such cases they are entitled to use force. Suspects are not aware of the differences between their own rights and responsibilities in such a situation and the authority that police officers legally have to use of force in order to perform their legal tasks.
Internetbankieren: veiligheidspercepties van gebruikers
Authors: Jansen Jurjen , Kop Nicolien , Stol Wouter 
Published: March 2017

End-user perceptions of safety and security of online banking
In today’s society, full use is made of online banking. This makes safety and security of online banking an important issue. Two significant threats to users of online banking in The Netherlands are phishing and malware attacks. In this study, an end-user perspective is adopted to study customers’ perceptions regarding safety and security of online banking. A unique feature to this study is that we explore – besides other predictor variables – the relationship between online banking fraud victimization and risk perception. We have made a distinction between three types of victimization: 1) self-experienced victimization, 2) victimization of acquaintances, such as family and friends, and 3) having heard of stories in the media about online banking fraud victimization. Based on a secondary analysis of data from 1200 Dutch users of online banking, collected through an online survey, we conclude that participants perceive their risk of online banking fraud to be small. In general, participants have little experience with victimization, both themselves (2.3%) and in social settings (29.6%). Three quarters of the respondents (75.6%) are aware of victimization of online banking fraud by means of media coverage. Direct and indirect victimization, however, have almost no influence on risk perception regarding online banking fraud. Risk perception is mainly determined by perceived vulnerability, that is, the estimated probability of becoming a victim of online banking fraud. Furthermore, perceived severity or impact of online banking fraud and the degree of trust in online banking contribute to some extent to risk perception. In total, 64.0% of variance in risk perception was explained by the predictors perceived vulnerability, perceived severity, locus of control, trust in online banking, (in)direct experiences with victimization (self, acquaintances and media) and demographic variables (gender, age, educational level and work status). The results of this study may help to improve communication about risks regarding online banking.
Breeding behavior of female white‐tailed deer relative to conception: Evidence for female mate choice
Authors: Sullivan Jeffery D. , Ditchkoff Stephen S. , Collier Bret A. , Ruth Charles R. , Raglin Joshua B. 
Published: March 2017

AbstractFemale white‐tailed deer (Odocoileus virginianus) are thought to choose between two behavioral strategies to maximize the quality of potential mates: sit and wait, characterized by concentrating activity within a restricted area, and excursive behavior, characterized by increased activity and excursions outside the home range. As movement patterns may influence conception, our goal was to examine the patterns of female white‐tailed deer movements to evaluate which breeding strategy was employed. We equipped 36 female white‐tailed deer with GPS collars from August 2013 to December 2015. We found that movement rate and probability of activity were greatest near the peak of the breeding season, and we observed increases in both metrics during the 40 days prior to estimated conception. Peak size of home range and core area occurred in the days surrounding conception. We found that 11 deer performed an excursion, ranging from 43 days before until 36 days after conception, with the peak probability of being outside of an individual home range occurring 1 day prior to conception. Our results suggest that female white‐tailed deer may attempt to maximize the quality of their mates by advertising availability for breeding through excursive behaviors just prior to entering estrus.
The Gravity of High-Skilled Migration Policies
Authors: Czaika Mathias , Parsons Christopher R. 
Published: March 2017

AbstractCombining unique, annual, bilateral data on labor flows of highly skilled immigrants for 10 OECD destinations between 2000 and 2012, with new databases comprising both unilateral and bilateral policy instruments, we present the first judicious cross-country assessment of policies aimed to attract and select high-skilled workers. Points-based systems are much more effective in attracting and selecting high-skilled migrants than requiring a job offer, labor market tests, and shortage lists. Offers of permanent residency, while attracting the highly skilled, overall reduce the human capital content of labor flows because they prove more attractive to non-high-skilled workers. Bilateral recognition of diploma and social security agreements foster greater flows of high-skilled workers and improve the skill selectivity of immigrant flows. Conversely, double taxation agreements deter high-skilled migrants, although they do not alter overall skill selectivity. Our results are robust to a variety of empirical specifications that account for destination-specific amenities, multilateral resistance to migration, and the endogeneity of immigration policies.
CAREFREE IN CORFU? HORACE, EPISTLES 1.2.31
Authors: Traill David A. 
Published: March 2017

nos numerus sumus et frugis consumere nati,sponsi Penelopae nebulones Alcinoiquein cute curanda plus aequo operata iuuentus,cui pulchrum fuit in medios dormire dies et 30ad strepitum citharae cessatum ducere curam.ut iugulent hominem, surgunt de nocte latrones:ut te ipsum serues, non expergisceris?We are ciphers, born to eat bread, the worthless suitors of Penelope and the young men of Alcinous’ court, all too concerned with keeping their skin attractive, who thought it a fine thing to sleep till midday and * * * To murder a man, thieves get up at night; to save yourself, won't you wake up?
SOME NEW EXAMPLES OF SMASH-NILPOTENT ALGEBRAIC CYCLES
Authors: LATERVEER ROBERT 
Published: March 2017

AbstractVoevodsky has conjectured that numerical equivalence and smash-equivalence coincide for algebraic cycles on any smooth projective variety. Building on work of Vial and Kahn–Sebastian, we give some new examples of varieties where Voevodsky's conjecture is verified.
Kenosis, omniscience, and the Anselmian concept of divinity
Authors: ARCHER JOEL 
Published: March 2017

AbstractThe canonical gospels often portray Christ as limited in various ways, for example, with respect to knowledge. But how could Christ be divine yet fail to know certain true propositions? One prominent answer is known askenoticism, the view that upon becoming incarnate Christ ‘emptied’ himself of certain divine properties, including omniscience. A powerful objection to kenoticism, however, is that it conflicts with Anselmian intuitions about divinity. Specifically, kenoticism implies that Christ was not the greatest conceivable being. I articulate a modified version of kenoticism that avoids this powerful objection while remaining faithful to the depiction of Christ found in the gospels.
Examining the impact of forest protection status on firewood sufficiency in rural Africa
Authors: LATHAM JULIA EVELYN , SALLU SUSANNAH MARY , LOVERIDGE ROBIN , MARSHALL ANDREW ROBERT 
Published: March 2017

SUMMARYMillions of people living in poverty depend on non-timber forest products (NTFPs), yet forest protection causes displacement, replacement or reduction of NTFP extraction activities, with implications for human welfare. Here, we assess the impact of forest protection on a novel measure of wellbeing that incorporates both objective and subjective components of people's lives. In five villages near forests with mixed protection status in Tanzania, household perceived need for firewood is compared with actual consumption in order to provide a simple metric of firewood sufficiency. Firewood sufficiency varied with forest protection status, with non-compliance inferred by household ability to meet firewood needs despite forest access restrictions. Fuel-efficient stove ownership improved the perceived ability to meet firewood needs; however, actual consumption remained unchanged. Firewood sufficiency was significantly lower for those sourcing firewood outside forests, and increased household awareness of the management authority significantly reduced firewood consumption. In a forest landscape of mixed protection status, pressure will likely be displaced to the forest with the least active management authority, affecting their efficiency as non-extractive reserves. Our findings reinforce the need for a landscape approach to forest management planning that accounts for local needs, to avoid leakage to other less well-protected forests and detriment to household welfare.
Congenital pulmonary lymphangiectasia and early mortality after stage 1 reconstruction procedures
Authors: Herrmann Jeremy L. , Irons Mallory L. , Mascio Christopher E. , Rychik Jack , Spray Thomas L. , Gaynor J. William , Pogoriler Jennifer E. 
Published: March 2017

AbstractObjectivesPulmonary lymphangiectasia associated with hypoplastic left heart syndrome with an intact or restrictive atrial septum may result from increased left atrial pressure, and is associated with worse outcomes following staged reconstruction due to lung dysfunction and significant hypoxaemia. Our objective was to characterise the incidence of pulmonary lymphangiectasia in cases of early mortality following stage 1 reconstructions.MethodsAn institutional cardiac surgical database was retrospectively searched for patients who died within 30 days following a stage 1 reconstruction between 1 January, 1984 and 31 December, 2013. During that period, 1669 stage 1 procedures were performed. Autopsy lung specimens were reviewed by a paediatric pathologist. Patients who died of suspected technical issues were excluded.ResultsA total of 54 patients were included, and of these seven cases (8.5%) of pulmonary lymphangiectasia were identified. The mean estimated gestational age was 38.2±2.4 weeks, and the mean birth weight was 3.0±0.6 kg. The median interval between surgery and death was 1 day (with a range from 0 to 18 days). The atrial septum was intact in one patient (14.3%), restrictive in three patients (42.9%), and unrestrictive in three patients (42.9%).ConclusionsPulmonary lymphangiectasia may develop in hypoplastic left heart syndrome with or without a restrictive atrial septum. As standard prenatal diagnostic evaluations and treatment methods for pulmonary lymphangiectasia are limited, this may be an important contributor to early and late mortality following stage 1 reconstruction for hypoplastic left heart syndrome.
Dynamic transcriptomes identify biogenic amines and insect-like hormonal regulation for mediating reproduction in Schistosoma japonicum
Authors: Wang Jipeng , Yu Ying , Shen Haimo , Qing Tao , Zheng Yuanting , Li Qing , Mo Xiaojin , Wang Shuqi , Li Nana , Chai Riyi , Xu Bin , Liu Mu , Brindley Paul J , McManus Donald P , Feng Zheng , Shi Leming , Hu Wei 
Published: March 2017

AbstractEggs produced by the mature female parasite are responsible for the pathogenesis and transmission of schistosomiasis. Female schistosomes rely on a unique male-induced strategy to accomplish reproductive development, a process that is incompletely understood. Here we map detailed transcriptomic profiles of male and femaleSchistosoma japonicumacross eight time points throughout the sexual developmental process from pairing to maturation. The dynamic gene expression pattern data reveal clear sex-related characteristics, indicative of an unambiguous functional division between males and females during their interplay. Cluster analysis,in situhybridization and RNAi assays indicate that males likely use biogenic amine neurotransmitters through the nervous system to control and maintain pairing with females. In addition, the analyses indicate that reproductive development of females involves an insect-like hormonal regulation. These data sets and analyses serve as a foundation for deeper study of sexual development in this pathogen and identification of novel anti-schistosomal interventions.
Brigatinib combined with anti-EGFR antibody overcomes osimertinib resistance in EGFR-mutated non-small-cell lung cancer
Authors: Uchibori Ken , Inase Naohiko , Araki Mitsugu , Kamada Mayumi , Sato Shigeo , Okuno Yasushi , Fujita Naoya , Katayama Ryohei 
Published: March 2017

AbstractOsimertinib has been demonstrated to overcome the epidermal growth factor receptor (EGFR)-T790M, the most relevant acquired resistance to first-generation EGFR–tyrosine kinase inhibitors (EGFR–TKIs). However, the C797S mutation, which impairs the covalent binding between the cysteine residue at position 797 of EGFR and osimertinib, induces resistance to osimertinib. Currently, there are no effective therapeutic strategies to overcome the C797S/T790M/activating-mutation (triple-mutation)-mediated EGFR–TKI resistance. In the present study, we identify brigatinib to be effective against triple-mutation-harbouring cells in vitro and in vivo. Our original computational simulation demonstrates that brigatinib fits into the ATP-binding pocket of triple-mutant EGFR. The structure–activity relationship analysis reveals the key component in brigatinib to inhibit the triple-mutant EGFR. The efficacy of brigatinib is enhanced markedly by combination with anti-EGFR antibody because of the decrease of surface and total EGFR expression. Thus, the combination therapy of brigatinib with anti-EGFR antibody is a powerful candidate to overcome triple-mutant EGFR.
Prevalence of hypovitaminosis D and associated factors in obese Spanish children
Authors: Durá-Travé T , Gallinas-Victoriano F , Chueca-Guindulain M J , Berrade-Zubiri S 
Published: March 2017

Abstract
Background/Objectives:
Vitamin D deficiency may contribute to endocrine health and disease (diabetes, autoimmune thyroid diseases, polycystic ovarian syndrome, etc.). The aim of this study was to determine the prevalence and specific factors for hypovitaminosis D among children stratified by body mass index (BMI) in Northern Spain.

Subjects/Methods:
A cross-sectional clinical (sex, age, season of study visit, place of residence and BMI) and blood testing (calcium, phosphorous, calcidiol and parathyroid hormone (PTH)) were accomplished in 546 Caucasian individuals (aged 3.2–15.8 years). The BMI (Z-score) allowed establishing four groups: normal, overweight, obesity and severe obesity. The criteria of the US Endocrine Society were used for the definition of hypovitaminosis D.

Results:
Calcidiol levels were significantly higher in normal and overweight groups (P=0.001), whereas PTH levels were significantly higher in obesity and severe obesity groups (P=0.001). Hypovitaminosis D prevalence was significantly higher in severe obesity (81.1%) and obesity (68.2%) groups, whereas was lowest in overweight (55%) and normal (58.1%) groups (P=0.001). There was a negative correlation between calcidiol and PTH levels (P<0.01). Female (90.9%), adolescent group (88,2%), winter (100%) and autumn (82.4%) time and urban residence (94.1%) imply a higher prevalence of hypovitaminosis D in subjects with severe obesity (P<0.001). Female, puberal age, autumn, winter and spring time, urban residence and severe obesity were found to be independent predictors for hypovitaminosis D.

Conclusions:
Severe obesity could be considered as an associated factor for vitamin D deficiency, and, owing to its high prevalence, the implementation of systematic screening and hypovitaminosis treatment programs would be particularly useful.
FAM83A is amplified and promotes cancer stem cell-like traits and chemoresistance in pancreatic cancer
Authors: Chen S , Huang J , Liu Z , Liang Q , Zhang N , Jin Y 
Published: March 2017

AbstractCancer stem cells (CSCs), also known as tumor-initiating cells (TICs), contribute to tumorigenesis, resistance to chemoradiotherapy and recurrence in human cancers, suggesting targeting CSCs may represent a potential therapeutic strategy. In the current study, we found family with sequence similarity 83, member A (FAM83A) is significantly overexpressed and associated with poorer overall survival and disease-free survival in pancreatic cancer. Overexpression of FAM83A markedly promoted, whereas inhibition of FAM83A decreased, CSC-like traits and chemoresistance both in vitro and in an in vivo mouse model of pancreatic cancer. Furthermore, overexpression of FAM83A activated the well-characterized CSC-associated pathways transforming growth factor-β (TGF-β) signaling and Wnt/β-catenin signaling. Importantly, the FAM83A locus was amplified in a number of human cancers and silencing FAM83A in associated cancer cell lines inhibited activation of the WNT/β-catenin and TGF-β signaling pathways and reduced tumorigenicity. Taken together, these results indicate that FAM83A has a vital oncogenic role to promote pancreatic cancer progression and may represent a potential clinical target.
Overexpression of SMC4 activates TGFβ/Smad signaling and promotes aggressive phenotype in glioma cells
Authors: Jiang L , Zhou J , Zhong D , Zhou Y , Zhang W , Wu W , Zhao Z , Wang W , Xu W , He L , Ma Y , Hu Y , Zhang W , Li J 
Published: March 2017

AbstractOverexpression of structural maintenance of chromosomes 4 (SMC4) has been reported to be involved in tumor cell growth, migration and invasion, and to be correlated with poor prognosis of cancer patient. However, its clinical significance and biological role in glioma remain unknown. Herein, we found that SMC4 expression at both mRNA and protein level was markedly increased in glioma cells and clinical tissues and that it correlated with poor prognosis. SMC4 overexpression markedly promoted the glioma cell proliferation rate and migration and invasive capability in vitro and in vivo, whereas SMC4 downregulation reduced it. Moreover, the transforming growth factor β (TGFβ)/Smad signaling pathway, which was activated in SMC4-transduced glioma cells and inhibited in SMC4-silenced glioma cells, contributed to SMC4-mediated glioma cell aggressiveness. Our results provide new insight into the oncofunction of SMC4 and the mechanism by which the TGFβ/Smad pathway is hyperactivated in gliomas, indicating that SMC4 is a valuable prognostic factor and a potential therapeutic target in gliomas.
Enhanced Wnt Signalling in Hepatocytes is Associated with Schistosoma japonicum Infection and Contributes to Liver Fibrosis
Authors: Wang Qi , Chou Xin , Guan Fei , Fang Zhengming , Lu Shengjun , Lei Jiahui , Li Yonglong , Liu Wenqi 
Published: March 2017

AbstractLiver fibrosis is the most serious pathology caused by Schistosoma japonicum infection, which arises when schistosome eggs are deposited in the liver. Eosinophils, macrophages and hepatic stellate cells (HSCs) have been identified as major cellular contributors to the development of granulomas and fibrosis, but little is known about the effects of hepatocytes on granuloma formation. Here, we found that the levels of Wnt signalling-related molecules, transforming growth factor β (TGF-β) and connective tissue growth factor (CTGF) in hepatocytes were markedly elevated after S. japonicum infection. Liver fibrosis was exacerbated when exogenous Wnt3a was introduced, but was alleviated when Wnt signalling was suppressed by DKK1, accompanied by the reduced expression of TGF-β and CTGF in hepatocytes. These results indicate that the hepatocytic expression of TGF-β and CTGF is mediated by Wnt signalling. Additionally, the hepatocytes isolated from infected mice promoted the activation of primary HSCs in vitro, however, this effect was not observed when hepatocytes from DKK1 treated S. japonicum-infected mice was employed in the co-culture system. Our findings identify a novel pro-fibrogenic role of hepatocytes in schistosomiasis-induced liver fibrosis that is dependent on Wnt signalling, which may serve as a potential target for ameliorating hepatic fibrosis caused by helminths.