bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does official development assistance (ODA) cause the Dutch disease in developing countries
Authors: Nguyen Phuc Hien , Nguyen Viet Dung , Le Thi Kim Xuyen , Nguyen Van Cuong , Nguyen Van Minh 
Published: September 2024

PurposeThis paper aims to investigate whether official development assistance (ODA) inflows to developing countries (lower-middle and low income) can cause the symptoms of Dutch disease or not.Design/methodology/approachThis study applies the methodology of dynamic panel data estimation with a one-step system generalized methods of moment (GMM) for the sample of 59 developing countries from 2001 to 2019.FindingsThe results indicate that ODA (as a percentage of gross domestic product (GDP)) rises by 1%, the real effective exchange rate (REER) appreciates by 0.252%. This finding reveals that these selected developing countries have faced the symptoms of Dutch disease. The countries with the higher ODA ratio have a higher effect of the Dutch disease, and the managed floating exchange rate regime is the lowest impacted, when compared to the fixed and flexible exchange rate.Practical implicationsThe selected countries are recommended to use ODA inflows right and efficiently. These ODA inflows should be invested in productive sectors or support for production rather than in consumption. The managed float exchange rate regime is applied to reduce the symptom of Dutch disease for the selected countries. The good cooperation of monetary and fiscal policies is important to absorb the huge ODA inflow and sterilize the adverse effects of the disease.Originality/valueThe paper contributes to the literature and empirical of the Dutch disease. An adverse effect of the huge ODA inflow to the developing countries appreciated of the real exchange rate and caused the symptom of the dutch disease.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-12-2022-0777
Economic growth and sustainable development: evidence from OIC countries
Authors: Ul Haq Inzamam , Huo Chunhui , Saba Irum 
Published: September 2024

Purpose
This paper aims to examine the dynamic relationship between economic growth and sustainable development, integrating the Environmental Kuznets Curve (EKC) in 22 Organization of Islamic Cooperation (OIC) member countries across income groups.

Design/methodology/approach
Using annual data between 1990 and 2022, the authors apply the cross-correlation coefficient (CCC) approach of Narayan et al. (Economic Modeling, 2016, 53, 388–397) to examine the lead/lag relationship between GDP per capita and sustainable development. This study further validates the findings through a panel Granger causality test and a fixed panel regression model.

Findings
This research provides evidence of a U-shaped EKC for only 1 out of 22 (5%) OIC countries. For 13 out of the 22 (59%) OIC countries, increasing income growth is expected to enhance sustainable development in the future. The results show that as income levels rise, there will be a more significant decline in sustainable development for high-income OIC countries in the future than for both middle-income groups, contradicting the EKC hypothesis. The findings from the panel Granger causality and panel regression models also support the CCC results.

Originality/value
This study proposes a reverse version of the EKC hypothesis and contributes to the literature on economic growth and environmental sustainability. With increasing economic growth, the results can assist OIC member governments and policy-makers in designing tailored policies and practical measures for future sustainable development.
Bridging the health literacy gap through AI chatbot design: the impact of gender and doctor cues on chatbot trust and acceptance
Authors: Jin Eunjoo , Ryoo Yuhosua , Kim WooJin , Song Y. Greg 
Published: September 2024

PurposeNotwithstanding their potential benefits especially for individuals with low health literacy, users are still somewhat skeptical about the reliability of healthcare chatbots. The present study aims to address this challenge by investigating strategies to enhance users’ cognitive and emotional trust in healthcare chatbots. Particularly, this study aims to understand the effects of chatbot design cues in increasing trust and future chatbot use intention for low health literacy users.Design/methodology/approachWe conducted two experimental studies with a final sample of 327 (Study 1) and 241 (Study 2). Three different chatbots were developed (Chatbot design: Bot vs Male-doctor vs Female-doctor). Participants were asked to have a medical consultation with the chatbot. Participants self-reported their health literacy scores. The PROCESS model 7 was used to analyze the hypotheses.FindingsThe results showed that the female-doctor cues elicited greater cognitive and emotional trust, whereas the male-doctor cues only led to greater cognitive trust (vs bot-like cues). Importantly, this study found that users’ health literacy is a significant moderating factor in shaping cognitive and emotional trust. The results indicated that both the female and male-doctor cues’ positive effects on cognitive trust were significant for those with lower levels of health literacy. Furthermore, the positive effect of the female-doctor cues on emotional trust was also significant only for those whose health literacy level was low. The increased cognitive and emotional trust led to greater future intention to use the chatbot, confirming significant moderated mediation effects.Originality/valueDespite the strong economic and educational benefits of healthcare chatbots for low health literacy users, studies examining how healthcare chatbot design cues affect low health literate users surprisingly remained scarce. The results of this study suggest that healthcare chatbots can be a promising technological intervention to narrow the health literacy gap when aligned with appropriate design cues.
Subjective well-being perceptions of Portuguese Public Relations practitioners: a gender and stages of life analysis
Authors: Cunha Maria João , Cruz Carla , Belim Célia 
Published: September 2024

PurposeThis research aims to explore perceptions of subjective well-being (SWB) in public relations (PR) practitioners, focusing on dimensions of job satisfaction, networking, relationships and work–life balance, while addressing the under-researched area of gender and age – related to stages of life – disparities in SWB within the PR industry.Design/methodology/approachEmploying a mixed-methods sequential explanatory design, this study utilised a survey, followed by semi-structured interviews to investigate SWB among PR professionals in Portugal, considering gender and stages of life differences.FindingsUsing a gendered and stages of life lens, this study found nuanced perceptions of SWB among Portuguese PR professionals. Older women showed higher emotional well-being but lower work evaluations than men, while young professionals exhibited less gender disparities in SWB. Men reported greater job satisfaction, emphasising passion, while women faced challenges like work overload and valued recognition. Gender differences were seen in networking, with men favouring teamwork and women valuing friendships for career advancement. Work–life balance issues, especially among older women, related to mental health.Originality/valueThis study contributes to filling the research gap regarding SWB in the PR industry, particularly in Portugal, offering insights into gender and stages of life dynamics that influence SWB perceptions, thereby informing strategies for enhancing well-being and productivity in PR workplaces.
How life became colourful: colour vision, aposematism, sexual selection, flowers, and fruits
Authors: Wiens John J. , Emberts Zachary 
Published: September 2024

ABSTRACTPlants and animals are often adorned with potentially conspicuous colours (e.g. red, yellow, orange, blue, purple). These include the dazzling colours of fruits and flowers, the brilliant warning colours of frogs, snakes, and invertebrates, and the spectacular sexually selected colours of insects, fish, birds, and lizards. Such signals are often thought to utilize pre‐existing sensitivities in the receiver's visual systems. This raises the question: what was the initial function of conspicuous colouration and colour vision? Here, we review the origins of colour vision, fruit, flowers, and aposematic and sexually selected colouration. We find that aposematic colouration is widely distributed across animals but relatively young, evolving only in the last ~150 million years (Myr). Sexually selected colouration in animals appears confined to arthropods and chordates, and is also relatively young (generally <100 Myr). Colourful flowers likely evolved ~200 million years ago (Mya), whereas colourful fruits/seeds likely evolved ~300 Mya. Colour vision (sensu lato) appears to be substantially older, and likely originated ~400–500 Mya in both arthropods and chordates. Thus, colour vision may have evolved long before extant lineages with fruit, flowers, aposematism, and sexual colour signals. We also find that there appears to have been an explosion of colour within the last ~100 Myr, including >200 origins of aposematic colouration across nine animal phyla and >100 origins of sexually selected colouration among arthropods and chordates.
Autoimmune astrocytopathy double negative for AQP4‐IgG and GFAP‐IgG: Retrospective research of clinical practice, biomarkers, and pathology
Authors: Lin Pei‐Hao , Yao Hai‐Yan , Huang Li , Fu Cong‐Cong , Yao Xiao‐Li , Lian Chun , Zhang Shi‐Feng , Lai Wen‐Dong , Lin Guan‐Yan , Liao Sha , Yang Jie , Mao Zhi‐Feng , Liu Ding , Long Bao‐Yi , Yue Jia‐Jia , Gao Cong , Long You‐Ming 
Published: September 2024

AbstractObjectiveThe objective of this study is to investigate the presence of astrocyte antibodies in patients, excluding aquaporin‐4 or glial fibrillary acidic protein (GFAP) antibodies, while evaluating associated biomarkers and pathologies.MethodsPatient serum and cerebrospinal fluid (CSF) were tested for antibodies using tissue‐ and cell‐based assays. Neurofilament light chain (NFL) and GFAP in the CSF were detected using single‐molecule array (SIMOA).Results116 patients accepted SIMOA. Fifteen functional neurological disorders patients without antibodies were designated as controls. Thirty‐five patients were positive for astrocyte antibodies (Anti‐GFAP: 7; Anti‐AQP4: 7; unknown antibodies: 21, designed as the double‐negative group, DNAP). The most frequent phenotype of DNAP was encephalitis (42.9%), followed by myelitis (23.8%), movement disorders (19.0%), and amyotrophic lateral sclerosis‐like (ALS‐like) disease (14.2%). The levels of CSF GFAP and NFL in DNAP were higher than in the control (GFAP: 1967.29 [776.60–13214.47] vs 475.38 [16.80–943.60] pg/mL, p < 0.001; NFL: 549.11 [162.08–2462.61] vs 214.18 [81.60–349.60] pg/mL, p = 0.002). GFAP levels decreased in DNAP (n = 5) after immunotherapy (2446.75 [1583.45–6277.33] vs 1380.46 [272.16–2005.80] pg/mL, p = 0.043), while there was no difference in NFL levels (2273.78 [162.08–2462.61] vs 890.42 [645.06–3168.06] pg/mL, p = 0.893). Two brain biopsy patterns were observed: one exhibited prominent tissue proliferation and hypertrophic astrocytes, with local loss of astrocytes, while the other showed severe astrocyte depletion with loss of neurofilaments around the vessels. Eighteen patients received immunotherapy, and improved except one with ALS‐like symptoms. We identified anti‐vimentin in this patient.DiscussionThere are unidentified astrocyte antibodies. The manifestations of double‐negativity are heterogeneous; nevertheless, the pathology and biomarkers remain consistent with astrocytopathy. Immunotherapy is effective.
Development and characterization of topical formulation for maintenance therapy containing sorbitan monostearate with and without PEG‐100‐stearate
Authors: Schoenfelder Hans , Wiedemann Yvonne , Lunter Dominique Jasmin 
Published: September 2024

AbstractObjectiveBasic therapy is an integral part of the treatment of chronic skin diseases. However, the formulation of skin products should be analysed with respect to the physical stability and tolerance by the patients before applying them to diseased skin. In particular, the suitability of the formulation for use on damaged skin should be taken into consideration so that no exacerbation of the condition is caused.MethodsThe following approach investigated two formulations with the emulsifier sorbitan monostearate and one with the addition of polyethylene glycol 100 stearyl ether. The characterization included rheology, macroscopic and microscopic cream analysis compared to marketed products for basic therapy. Pyranine staining of stratum corneum (SC) and trans‐epidermal water loss (TEWL) measurements were performed with ex vivo porcine SC to asses skin barrier function.ResultsThe rheological characterization showed a gel‐like, viscoelastic behaviour of the formulations and a viscosity in the same order of magnitude as the marketed products. Staining with pyranine revealed that skin damage caused by sodium lauryl sulfate was compensated by treatment with the developed formulations. Following the same trend, TEWL results clearly showed decreasing values, which evidence improved skin barrier function.ConclusionIn conclusion, the developed sorbitan monostearate formulations can potentially improve deficient skin barrier function as a part of basic therapy of skin diseases and act as a superior alternative to market products comprising a minimum of well‐chosen ingredients.
Identification of two molecularly and prognostically distinct subtypes in acral melanoma using network prediction method
Authors: Yin Mingzhu , Zhang Yiding , Wang Wenhua , Zhao Shuang , Su Juan , Li Shao , Chen Xiang 
Published: September 2024

AbstractBackgroundAcral melanoma, characterized by its aggressiveness and poor prognosis compared to other melanoma subtypes, poses significant challenges in clinical management. However, the molecular underpinnings driving the biological and clinical features of this disease remain poorly understood.ObjectivesIn this study, our aim was to elucidate the molecular landscape and the correlation between subtypes and clinical features of acral melanoma.MethodsWe conducted comprehensive analyses to dissect the molecular characteristics of acral melanoma, employing a combination of multi‐omics data analysis and network‐based disease gene prediction algorithms. Single‐cell RNA‐Seq data were utilized to investigate the contribution of immunocytes to the molecular classification of acral melanoma. Additionally, we used clinical samples to validate the correlation between new subtypes and the prognosis of acral melanoma and the expression of subtype markers and verified the interaction between macrophages and acral melanoma cells at cellular level.ResultsOur study reveals the existence of two distinct subtypes of acral melanoma exhibiting marked differences in clinical behaviour, cellular and molecular mechanisms. We identified a robust biomarker panel (EREG, VSIG4, FCGR3A and RAB20) that accurately distinguishes these two subtypes with an impressive AUC of 0.946, validated using clinical samples. Subtype I, characterized by thinner Breslow thickness, demonstrates a favourable prognosis, whereas Subtype II represents a high‐risk subtype with a propensity for dermal invasion. Notably, the signature gene EREG of Subtype I is enriched in FCN1+ macrophages, known for promoting inflammatory and immune responses. Conversely, signature genes VSIG4 and FCGR3A of Subtype II are enriched in SPP1+ macrophages, which exhibit significant crosstalk with tumour cells.ConclusionsOur findings significantly enhance the understanding of the molecular landscape of acral melanoma and offer novel insights into its clinical management by identifying distinct subtypes and potential therapeutic targets. The findings have to be confirmed in different cohorts in the future for full validation.
Inter‐algal associations and nutrients linked by Scenedesmus and Desmodesmus structure eukaryotic algal communities
Authors: Lin Juan , Wang Hongxia , Chen Jianfeng , Li Yun 
Published: September 2024

AbstractEutrophication reduces the variability of the community composition of plankton. However, the mechanisms underlying the diversity and restructuring of eukaryotic algal communities remain unknown. This study analysed the diversity and compositional patterns of algal communities in shallow eutrophic lakes. It investigated how these communities were modified by key genera through mediating inter‐algal associations under the influence of abiotic factors. Inter‐algal associations explained more variance in algal communities than environmental variables, and variation in composition and diversity was primarily derived from Scenedesmus, Desmodesmus and Cryptomonas, rather than nutrients. Scenedesmus and Desmodesmus were positively correlated with the genera of Chlorophyta and formed the hub of the algal association network. When the relative abundance of Scenedesmus and Desmodesmus increased from 0.41% to 13.74%, communities enriched in biomarkers of Bacillariophyta, Chrysophyceae and Cryptophyta transitioned to communities enriched in biomarkers of Chlorophyta. Moreover, negative associations between the Chlorophyta hub genera and other non‐Chlorophyta genera increased. High concentrations of total phosphorus altered the composition of algal communities by increasing the abundance of Scenedesmus and Desmodesmus, which in turn had cascading effects through inter‐algal associations. Additionally, algal communities with higher abundances of Scenedesmus and Desmodesmus were more susceptible to the effects of total phosphorus. Our study suggested that inter‐algal associations, centred on Scenedesmus and Desmodesmus, had a greater influence on algal diversity and community structure than other factors. Nutrient levels were not a direct driver of algal diversity and community structure adjustments, but acted indirectly by enhancing the influence of Scenedesmus and Desmodesmus.
ПРОБИОТИЧЕСКИЕ ПРЕПАРАТЫ И ИХ СВОЙСТВА
Authors: Жакупова Д.С. , Хасенова А.Е. , Альжанова Г.С. , Ерғазы Б. 
Published: September 2024

Рынок пробиотиков является одним из наиболее быстрорастущих сегментов пищевой промышленности, поскольку появляется все больше научных доказательств положительного воздействия пробиотиков на здоровье потребителей.
В связи с этим в филиале «Национального центра биотехнологии» в г. Степногорск, нами уделяется большое внимание для работы по выделению и изучению свойств пробиотических штаммов, а также их взаимодействию с другими активными добавками.
Пробиотические и кисломолочные бактерии Lactococcus lactis, Lactobacillus rhamnosus, Lactobacillus zeae, Lactobacillus plantarum, Lactobacillus acidophillus, Lactobacillus helveticus, Lactobacillus bulgaricus, Bifidobacterium bifidum, Streptococcus cremoris, Streptococcus thermophilus выделены из домашних кисломолочных напитков. Штаммы идентифицированы по биохимическим, культурально-морфологическим свойствам и методом генетической идентификации, задепонированы в депозитарии ТОО «КАЗНИИППП», исследованы на патогенность в ТОО «Нутритест» и хранятся в коллекции филиала.
Отработана технология сублимированной формы пробиотических микроорганизмов и подобраны оптимальные консерванты для максимального сохранения жизнеспособности клеток.
На основе полученных пробиотических микроорганизмов разработана технология получения биологически активных добавок. Во время хранения и доставки при пероральном приеме, пробиотики подвергаются воздействию воды, кислорода, температуры и желчи. В связи с этим биологически активные добавки представлены в одной из наиболее доступных лекарственных форм, в виде капсул.
Препарат «BioLife» представляет собой микробную массу живых, антагонистически активных штаммов Bifidobacterium bifidum с добавлением стабилизатора. В качестве стабилизатора был подобран наполнитель-пребиотик лактулоза, способствующий сохранению биологической активности Bifidobacterium bifidum. Лактулоза является не только самостоятельным ферментом, но и способствует размножению нормальной микрофлоры кишечника, оказывает слабительное действие.
Препарат «Биолакт» изготовлен на основе высушенных пробиотически активных культур. Является синбиотиком, содержит в своем составе пробиотические штаммы: Lactobacillus acidophilus, Bifidobacterium bifidum. Препарат используется в молочнокислой промышленности для обогащения кисломолочных продуктов, также в качестве биологически активной добавки как дополнительный источник пробиотических микроорганизмов.
В результате проведенных исследований разработаны биологически активные добавки, которые применяются в качестве пробиотиков для нормализации и восстановления нормальной микрофлоры кишечника при антибиотикотерапии, химиотерапии, расстройстве желудочно-кишечного тракта.
«BioLife» и «Биолакт» прошли регистрационные испытания и зарегистрированы под номером KZ.16.01.78.003. Е.001132.05.13 и KZ.16.01.78.003. Е.002324.10.14 соответственно.
РАСПРОСТРАНЕННОСТЬ АЛЬФАКОРОНАВИРУСОВ СРЕДИ ЛЕТУЧИХ МЫШЕЙ В КАЗАХСТАНЕ
Authors: Карагулов А.И. , Наметов А.М. , Тулендибаев А.Б. , Аргимбаева Т. , Омарова З.Д. , Аубакир Н. , Орынбаев М.Б. 
Published: September 2024

Известно, что летучие мыши являются идеальным резервуаром для различных вирусов. Однако мало что известно о разнообразии и распространении вирусов, переносимых летучими мышами в Казахстане. Настоящее исследование одно из немногих работ посвященный изучению летучих мышей, обитающих на территории Казахстана на носительство коронавирусов.
В 2020-22 гг в девяти областях Казахстана было собрано 800 образцов (ротоглоточные смывы, гуано) от четырех видов летучих мышей (Vespertilio murinus, Myotis blythii, Nyctalus noctula, Eptesicus serotinus). РНК альфакоронавирусов обнаружены в 39 (4,7%) образцах от летучих мышей. Альфакоронавирусы были обнаружены у трех видов исследованных летучих мышей. Инфицированность летучих мышей вида Vespertilio murinus составила 0,85%, Eptesicus serotinus 9,94%, Myotis blythii 27,27%. Превалентность коронавируса среди летучих мышей в Алматинской области составила 100%, Атырауской области 18,18%, Актюбинсокй области 13,92%, Западно-Казахстанской области 5,16%, Туркистанской области 1,39%, в Кызылординской области 0,66%. В других областях РНК коронавирусов в образцах от летучих мышей не обнаружены.
Нам удалось получить последовательности гена RdRp (460 п.н.) 11 образцов от летучих мышей собранные в 5 областях Казахстана (Западно-Казахстанской, Актюбинсокой, Атырауской, Кызылоридинской и Туркестанской областях). Филогенетический анализ позволил отнести все последовательности к альфакоронавирусам, и разделить их на две разные группы. Десять последовательностей сформировали отдельную новую монофилетическую одиночную кладу с 100%-ной идентичностью нуклеотидных последовательностей. Эта клада была филогенетически близка к африканским последовательностям. Наиболее близкими к этой группе были последовательности, полученные от летучих мышей в Гане, Зимбабве и Кении. Одна последовательность (BatCov-47-2021) от летучей мыши из Туркестанской области заметно отличалась (идентичность нуклеотидов: 71.98%) от остальных 10 последовательностей, и была идентична казахстанским изолятам, ранее выделенным в южных регионах Казахстан.
Полученные данные доказывают, что летучие мыши, обитающие на территории Казахстана, являются носителями коронавирусов. Эти данные предоставили новую информацию и расширили знания о распространении коронавирусов в популяциях летучих мышей. Однако этих данных недостаточно для понимания роли летучих мышей в эпидемиологии различных инфекционных заболеваний. Поэтому необходимо продолжить исследования в популяциях летучих мышей для улучшения надзора за инфекционными болезнями.