bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rationale, design, and baseline characteristics of the CLARIFY registry of outpatients with stable coronary artery disease
Authors: Sorbets Emmanuel , Greenlaw Nicola , Ferrari Roberto , Ford Ian , Fox Kim M. , Tardif Jean‐Claude , Tendera Michal , Steg Philippe Gabriel ,   on behalf of the CLARIFY Investigators
Published: May 2017

BackgroundDespite major advances in prevention and treatment, coronary artery disease (CAD) remains the leading cause of death worldwide. Whereas many sources of data are available on the epidemiology of acute coronary syndromes, fewer datasets reflect the contemporary management and outcomes of stable CAD patients.HypothesisA worldwide contemporary registry would improve our knowledge about stable CAD. The main objectives are to describe the demographics, clinical profile, contemporary management and outcomes of outpatients with stable CAD; to identify gaps between evidence and treatment; and to investigate long‐term prognostic determinants.Methods
CLARIFY (ProspeCtive observational LongitudinAl RegIstry oF patients with stable coronary arterY disease) is an ongoing international observational longitudinal registry. Stable CAD patients from 45 countries in Europe, Asia, America, Middle East, Australia and Africa were enrolled between November 2009 and June 2010. The inclusion criteria were previous myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischemia or prior revascularization procedure. The main exclusion criteria were serious non‐cardiovascular disease, conditions interfering with life expectancy or severe other cardiovascular disease (including advanced heart failure). Follow‐up visits were planned annually for up to 5 years, interspersed with 6‐month telephone calls.ResultsOf the 32,703 patients enrolled, most (77.6%) were male, age (mean ± SD) was 64.2 ± 10.5 years, and 71.0% were receiving treatment for hypertension; mean ± SD resting heart rate was 68.2 ± 10.6 bpm. Patients were enrolled based on a history of myocardial infarction >3 months earlier (57.7%), having at least one stenosis >50% on coronary angiography (61.1%), proven symptomatic myocardial ischemia on non‐invasive testing (23.1%), or history of percutaneous coronary intervention or coronary artery bypass graft (69.8%). Baseline characteristics were similar across the four subgroups identified by the four inclusion criteria.Conclusion
CLARIFY will provide a useful resource for understanding the current epidemiology of stable CAD.
Association between insomnia and atrial fibrillation in a Chinese population: A cross‐sectional study
Authors: Han Xu , Yang Yiheng , Chen Yue , Gao Lianjun , Yin Xiaomeng , Li Huihua , Qiu Jing , Wang Youxin , Zhou Yong , Xia Yunlong 
Published: May 2017

BackgroundInsomnia is the most prevalent sleep disorder; however, little research has explored the link between insomnia and atrial fibrillation (AF).HypothesisInsomnia is associated with increased risk of AF in a Chinese population.MethodsA total of 8371 Chinese participants (4314 males; mean age, 42.4 ± 13.1 years) were enrolled in this cross‐sectional study to investigate the association between insomnia and AF. AF was assessed in a standard supine resting position with a 10‐s 12‐lead electrocardiograph (ECG) or by self‐reported history. Insomnia was assessed using the Athens Insomnia Scale (AIS), and a score of ≥6 was regarded as having insomnia. The association between insomnia and AF was determined by logistic regression analysis.ResultsAmong the 8371 subjects, 1074 (12.8%) had different degrees of insomnia, and AF was observed in 50 subjects (0.60%). After adjusting for potential confounders, individuals with insomnia had moderately increased likelihood of suffering from AF compared with those without insomnia (odds ratio [OR]: 1.92, 95% confidence interval [CI]: 1.00‐3.70, P = 0.05). After stratifying data by age, a significant positive association was found in those age <40 years (OR: 6.52, 95% CI: 1.64‐25.83, P = 0.01), and a similar trend existed in males after stratifying by sex, although this relationship was not statistically significant (OR: 2.11, 95% CI: 0.92‐4.83, P = 0.08).ConclusionsIndividuals with insomnia may have a higher risk of AF in the particular Chinese population assessed in this study. Age (<40 years) is a significant factor in the association between insomnia and AF.
Visual system pathology in humans and animal models of blast injury
Authors: DeWalt Gloria J. , Eldred William D. 
Published: May 2017

AbstractInjury from blast exposure is becoming a more prevalent cause of death and disability worldwide. The devastating neurological impairments that result from blasts are significant and lifelong. Progress in the development of effective therapies to treat injury has been slowed by its heterogeneous pathology and the dearth of information regarding the cellular mechanisms involved. Within the last decade, a number of studies have documented visual dysfunction following injury. This brief review examines damage to the visual system in both humans and animal models of blast injury. The in vivo use of the retina as a surrogate to evaluate brain injury following exposure to blast is also highlighted.
Pd‐Metalated Conjugated Nanoporous Polycarbazoles for Additive‐Free Cyanation of Aryl Halides: Boosting Catalytic Efficiency through Spatial Modulation
Authors: Ding Shunmin , Tian Chengcheng , Zhu Xiang , Abney Carter W. , Tian Ziqi , Chen Bo , Li Meijun , Jiang De‐en , Zhang Ning , Dai Sheng 
Published: May 2017

AbstractInvited for this month′s cover is the group of Sheng Dai at the University of Tennessee, Knoxville. The image shows how the catalytic efficiency in nanoporous conjugated polymers can be boosted through spatial modulation. The Communication itself is available at 10.1002/cssc.201700329.
Higher order statistics applied to IR‐UWB system based on M‐OAM
Authors: Maatougui Lamyae , Sakkila Laila , Rivenq Menhaj Atika , Hajjaji Abdelowahed , Ouahmane Hassan 
Published: May 2017

SummaryIn this paper, an original communication system based on the ultra‐wideband technology and dedicated to intelligent transport systems is proposed. The ultra‐wideband presents a promising option for short‐range wireless communication system due to the transmission of very short pulses with low energy. To ensure reliability, safety, and security in the road, the proposed system must provide high data rate and good quality of service. The high data rate is ensured by the use of new modulation Orthogonal Amplitude Modulations. The quality of transmission is improved by the implementation of higher order statistic method at the receiver to eliminate the Gaussian noise and perform more precise decoding. Therefore, good performances in terms of bit error rate are guaranteed.
Peripancreatic paraganglioma mimics pancreatic/gastrointestinal neuroendocrine tumor on fine needle aspiration: Report of two cases and review of the literature
Authors: Zeng Jennifer , Simsir Aylin , Oweity Thaira , Hajdu Cristina , Cohen Steven , Shi Yan 
Published: May 2017

AbstractCytologic diagnosis of extra‐adrenal paraganglioma presenting as a peripancreatic mass is challenging with a high error rate due to its rarity. We report two cases of peripancreatic masses identified by radiology. Endoscopic ultrasound‐guided fine needle aspiration (FNA) of the masses showed a moderately cellular tumor composed of small to medium sized neoplastic cells with round to oval nuclei, arranged singly and in loose clusters. Focal rosette‐like structures were present. The cells were positive for neuroendocrine markers (synaptophysin and chromogranin). A diagnosis of a neoplasm with neuroendocrine differentiation and neuroendocrine tumor was made respectively on FNA for each case. The subsequent surgical resection of the tumors revealed peripancreatic paraganglioma. Although paraganglioma has been reported in the literature, the detailed comparison of perpancreatic paraganglioma versus pancreatic/gastrointestinal neuroendocrine tumor is still lacking. Therefore using these two cases with literature review, we wish to illustrate the differential diagnosis between these two entities based on cytomorphology and immunohistochemical study.
Innervation of the medial prefrontal cortex by tyrosine hydroxylase immunoreactive fibers during adolescence in male and female rats
Authors: Willing Jari , Cortes Laura R. , Brodsky Joseph M. , Kim Taehyeon , Juraska Janice M. 
Published: May 2017

AbstractAdolescence is associated with continued maturation of the cerebral cortex, particularly the medial prefrontal cortex (mPFC). We have previously documented pruning in the number of neurons, dendrites, and synapses in the rat mPFC from preadolescence to adulthood, with the period of pubertal onset being particularly important. We hypothesized that dopaminergic innervation of this region, critical for executive functions, would also be influenced by pubertal onset. Here, we measured changes in the volume of tyrosine hydroxylase (TH) immunoreactive axons in all layers of the male and female mPFC from preadolescence to adulthood (postnatal Day (P) 25, 35, 45, 60, and 90) as a marker of dopaminergic innervation. Assessing both total fiber volume and length, TH fibers were quantified by multiplying the mPFC volume by fiber density. While there were subtle layer‐specific changes, TH fiber volume and length increased between P25 and P90 in both males and females. Contrary to our hypothesis, a role for pubertal onset in TH innervation of this region was not discernable. In summary, axons immunoreactive for TH increase with similar trajectories in the mPFC of male and female rats from pre‐puberty to young adulthood.
A New Sodium‐Based Aqueous Rechargeable Battery System: The Special Case of Na0.44MnO2/Dissolved Sodium Polysulfide
Authors: Tekin Burak , Sevinc Serkan , Morcrette Mathieu , Demir‐Cakan Rezan 
Published: May 2017

AbstractHerein, the electrochemical performance of a new sodium‐based aqueous rechargeable battery is demonstrated consisting of Na0.44MnO2 as cathode and dissolved sodium polysulfide (i.e., Na2S5) as anolyte. Na0.44MnO2 synthesized through a solid‐state reaction method and dissolved Na2S5 anolyte are tested separately in a half‐cell configuration, both giving rise to stable cycling performances. As the anode side of the desired full‐cell configuration is at present dissolved in the electrolyte, the positive and negative electrodes need to be separated with an ion‐selective membrane that is permeable to sodium ions and impermeable to polysulfide species. Hence, Nafion is tested as a barrier to prevent the leakage of the dissolved polysulfides. After careful tuning of the osmotic pressure inside the Nafion membrane, leakage of the dissolved polysulfide from the anode to the cathode side is eliminated, resulting in a 0.8 V average voltage, low‐cost sodium‐ion aqueous cell.
A cell‐based smoothed finite element method with semi‐implicit CBS procedures for incompressible laminar viscous flows
Authors: Jiang Chen , Zhang Zhi‐Qian , Han Xu , Liu Guirong , Lin Tao 
Published: May 2017

SummaryIn this paper, the cell‐based smoothed finite element method (CS‐FEM) with the semi‐implicit characteristic‐based split (CBS) scheme (CBS/CS‐FEM) is proposed for computational fluid dynamics. The 3‐node triangular (T3) element and 4‐node quadrilateral (Q4) element are used for present CBS/CS‐FEM for two‐dimensional flows. The 8‐node hexahedral element (H8) is used for three‐dimensional flows. Two types of CS‐FEM are implemented in this paper. One is standard CS‐FEM with quadrilateral gradient smoothing cells for Q4 element and hexahedron cells for H8 element. Another is called as n‐sided CS‐FEM (nCS‐FEM) whose gradient smoothing cells are triangles for Q4 element and pyramids for H8 element. To verify the proposed methods, benchmarking problems are tested for two‐dimensional and three‐dimensional flows. The benchmarks show that CBS/CS‐FEM and CBS/nCS‐FEM are capable to solve incompressible laminar flow and can produce reliable results for both steady and unsteady flows. The proposed CBS/CS‐FEM method has merits on better robustness against distorted mesh with only slight more computation time and without losing accuracy, which is important for problems with heavy mesh distortion. The blood flow in carotid bifurcation is also simulated to show capabilities of proposed methods for realistic and complicated flow problems.
Fish burger enriched by olive oil industrial by‐product
Authors: Cedola Annamaria , Cardinali Angela , Del Nobile Matteo Alessandro , Conte Amalia 
Published: May 2017

AbstractOil industry produces large volume of waste, which represents a disposal and a potential environmental pollution problem. Nevertheless, they are also promising sources of compounds that can be recovered and used as valuable substances. The aim of this work is to exploit solid olive by‐products, in particular dry olive paste flour (DOPF) coming from Coratina cultivar, to enrich fish burger and enhance the quality characteristics. In particular, the addition of olive by‐products leads to an increase of the phenolic content and the antioxidant activity; however, it also provokes a deterioration of sensory quality. Therefore, to balance quality and sensory characteristics of fish burgers, three subsequent phases have been carried out: first, the quality of DOPF in terms of phenolic compounds content and antioxidant activity has been assessed; afterward, DOPF has been properly added to fish burgers and, finally, the formulation of the enriched fish burgers has been optimized in order to improve the sensory quality. Results suggested that the enriched burgers with 10% DOPF showed considerable amounts of polyphenols and antioxidant activity, even though they are not very acceptable from the sensory point of view. Pre‐treating DOPF by hydration/extraction with milk, significantly improved the burger sensory quality by reducing the concentration of bitter components.
Emotion regulation deficits in regular marijuana users
Authors: Zimmermann Kaeli , Walz Christina , Derckx Raissa T , Kendrick Keith M. , Weber Bernd , Dore Bruce , Ochsner Kevin N. , Hurlemann René , Becker Benjamin 
Published: May 2017

AbstractEffective regulation of negative affective states has been associated with mental health. Impaired regulation of negative affect represents a risk factor for dysfunctional coping mechanisms such as drug use and thus could contribute to the initiation and development of problematic substance use. This study investigated behavioral and neural indices of emotion regulation in regular marijuana users (n = 23) and demographically matched nonusing controls (n = 20) by means of an fMRI cognitive emotion regulation (reappraisal) paradigm. Relative to nonusing controls, marijuana users demonstrated increased neural activity in a bilateral frontal network comprising precentral, middle cingulate, and supplementary motor regions during reappraisal of negative affect (P < 0.05, FWE) and impaired emotion regulation success on the behavioral level (P < 0.05). Amygdala‐focused analyses further revealed impaired amygdala downregulation in the context of decreased amygdala–dorsolateral prefrontal cortex functional connectivity (P < 0.05, FWE) during reappraisal in marijuana users relative to controls. Together, the present findings could reflect an unsuccessful attempt of compensatory recruitment of additional neural resources in the context of disrupted amygdala–prefrontal interaction during volitional emotion regulation in marijuana users. As such, impaired volitional regulation of negative affect might represent a consequence of, or risk factor for, regular marijuana use. Hum Brain Mapp 38:4270–4279, 2017. © 2017 Wiley Periodicals, Inc.
Impact of positive margins on outcomes of oropharyngeal squamous cell carcinoma according to p16 status
Authors: Molony Peter , Kharytaniuk Natallia , Boyle Seamus , Woods Robbie S. R. , O'Leary Gerard , Werner Reiltin , Heffron Cynthia , Feeley Linda , Sheahan Patrick 
Published: May 2017

AbstractBackgroundCurrently, positive surgical margins in head and neck cancer are considered to be an indicator for postoperative chemoradiotherapy (CRT) over radiotherapy (RT) alone. However, there are less data regarding the impact of margin status on human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (SCC).MethodsWe performed a retrospective review of 55 patients with oropharyngeal SCC undergoing primary surgical treatment. The impact of margin status on disease‐specific survival (DSS) was studied according to p16 status.ResultsTwenty‐one patients had positive margins. Adjuvant treatment in these cases was CRT (n = 6), RT alone (n = 14), and none (n = 1). Among p16‐negative patients, positive margins and dysplasia at margins predicted significantly worse DSS. Among patients with p16‐positive disease, margin status had no impact on DSS.ConclusionPatients with p16‐positive oropharyngeal SCC and positive margins after excision maintain a low risk of recurrence despite most receiving RT alone as adjuvant treatment. These findings raise questions regarding the additional benefit of postoperative CRT in this group.
Complete remission with romidepsin in a patient with T‐cell acute lymphoblastic leukemia refractory to induction hyper‐CVAD
Authors: Brunvand Mark W. , Carson John 
Published: May 2017

AbstractT‐cell acute lymphoblastic leukemia (T‐ALL) and T‐cell lymphoblastic lymphoma (T‐LBL) are neoplasms that originate from T‐cell precursors. Outcomes in adult patients with T‐ALL/LBL remain unsatisfactory; early relapse following intensive induction chemotherapy is a concern, and patients with relapsed or refractory disease have a poor prognosis. Romidepsin is a potent, class 1 selective histone deacetylase inhibitor approved for the treatment of patients with peripheral T‐cell lymphoma who have had ≥1 prior therapy and patients with cutaneous T‐cell lymphoma who have had ≥1 prior systemic therapy. Here, we report the case of an adult patient with T‐ALL refractory to induction hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (hyper‐CVAD). Treatment with romidepsin was initiated, and romidepsin in combination with hyper‐CVAD resulted in complete remission, with mild tumor lysis syndrome as the only detectable additional toxicity. The patient eventually underwent allogeneic stem cell transplant while in first complete remission. Prior studies have shown that romidepsin is capable of inducing durable responses with manageable toxicities in patients with mature T‐cell lymphomas. This case study describes the successful use of romidepsin in combination with hyper‐CVAD in an adult patient with refractory T‐ALL and highlights the activity of romidepsin in the T‐cell lineage. The potential of romidepsin‐containing regimens in patients with T‐ALL/LBL deserves further study.
Assessment of serum β‐hCG and lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy
Authors: Revankar Vijaya M. , Narmada Lavu 
Published: May 2017

AbstractObjectiveTo assess and compare the ability of serum β‐human chorionic gonadotropin (β‐hCG) and serum lipid profile in early second trimester as predictors of hypertensive disorders of pregnancy.MethodsThe present hospital‐based prospective study was conducted between November 24, 2012, and April 30, 2014, at a tertiary hospital in Mangalore, India. Women of any parity with a pregnancy of 14–20 weeks were included. Venous blood (3 mL) was collected, and serum β‐hCG and lipid profile were estimated by enzyme‐linked immunosorbent assay and an enzymatic colorimetric test with lipid clearing factor, respectively. A cutoff value of β‐hCG for predicting hypertensive disorders was obtained by receiver operating curve analysis.ResultsSerum β‐hCG was significantly higher among women who subsequently developed hypertension (71 142 IU/L [n=27]) than among those who did not (20 541 IU/L [n=137]; P<0.001). The sensitivity and specificity of serum β‐hCG to predict hypertension were 92.6% and 94.9% respectively. The positive and negative predictive values were 78.1% and 98.5%, respectively.ConclusionSerum β‐hCG might be used as a predictor of hypertensive disorders that complicate pregnancy. Dyslipidemia was not found to be a useful marker.
Safety and Pharmacokinetics of Bendamustine Rapid‐Infusion Formulation
Authors: Cheung Eric M. , Edenfield William J. , Mattar Bassam , Anthony Stephen P. , Mutch Peter J. , Chanas Brian , Smith Mark , Hepner Adrian 
Published: May 2017

AbstractBendamustine hydrochloride (BDM) is approved in the United States to treat chronic lymphocytic leukemia and relapsed indolent B‐cell non‐Hodgkin lymphoma. The first formulation marketed in the United States (original BDM) was a lyophilized product requiring reconstitution prior to dilution to the final admixture. A liquid formulation of BDM was subsequently introduced that did not require reconstitution before dilution. Both formulations are administered as a 500 mL admixture with a recommended infusion time of 30 or 60 minutes for chronic lymphocytic leukemia and indolent B‐cell non‐Hodgkin lymphoma, respectively. A newer liquid BDM formulation (rapid BDM) is a ready‐to‐dilute solution not requiring reconstitution that dilutes into an admixture of only 50 mL and can be safely administered in a shorter infusion time (10 minutes). Rapid BDM admixture also has longer stability at room temperature than both lyophilized and liquid BDM formulations (6 vs 2 to 3 hours). This phase 1, open‐label, randomized, crossover (3‐period, partially replicated) study, conducted in “end‐of‐life” cancer patients at 10 oncology centers in the United States, demonstrates that rapid BDM is bioequivalent to original BDM as determined by area under the curve. Expected differences in maximum plasma concentration and time to maximum plasma concentration were observed between study treatments, given the substantially shorter infusion time of rapid BDM. No clinically relevant differences in other evaluated pharmacokinetic parameters were found. Rapid BDM infusions were safe and tolerable for cancer patients in this study. The overall safety profiles of the 2 BDM formulations were comparable, with no new safety signals identified and no differences in infusion‐related adverse events.