bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cervical Cancer Incidence in the US-Affiliated Pacific Islands
Authors: Gopalani Sameer V. , Qin Jin , Baksa Janos , Thompson Trevor D. , Saraiya Mona , Senkomago Virginia , Pordell Paran , Jeong Youngju , Palafox Neal A. , Reichhardt Martina , Buenconsejo-Lum Lee E. 
Published: September 2024

ImportanceThe World Health Organization has called for eliminating cervical cancer as a public health problem. Accurate and up-to-date estimates of population-based cervical cancer incidence are essential for monitoring progress toward elimination and informing local cancer control strategies, but these estimates are lacking for the US-Affiliated Pacific Islands (USAPI).ObjectiveTo calculate age-standardized incidence rates for cervical cancer in the 6 USAPI and compare these rates with rates in the US (50 states and the District of Columbia).Design, Setting, and ParticipantsThis cross-sectional study used population-based data from the Pacific Regional Central Cancer Registry for women aged 20 years or older who were diagnosed with invasive cervical cancer from January 1, 2007, to December 31, 2020. The registry comprises data on all cervical cancers from the USAPI, which include 3 US territories (American Samoa, Commonwealth of the Northern Mariana Islands, and Guam) and 3 freely associated states (Federated States of Micronesia [FSM], Republic of the Marshall Islands [RMI], and Republic of Palau). Data were analyzed from July 10, 2023, to November 28, 2023.Main Outcomes and MeasuresThe main outcome was age-standardized cervical cancer incidence rates, stratified by age, stage, and histologic code for the USAPI using population estimates from 3 different sources (US Census Bureau International Database, United Nations Population Division, and Pacific Data Hub). Rate ratios were calculated to compare incidence rates between the USAPI and the US.ResultsFrom 2007 to 2020, 409 cases of cervical cancer were diagnosed in the USAPI (median age at diagnosis, 46.0 years [25th-75th percentile, 39.0-55.0 years]), with an age-standardized incidence rate ranging from 21.7 (95% CI, 19.6-23.9) to 22.1 (95% CI, 20.0-24.4) per 100 000 women, depending on the population estimate. Incidence rates were highest in RMI, ranging from 58.1 (95% CI, 48.0-69.7) to 83.4 (95% CI, 68.3-101.0) per 100 000 women, followed by FSM, ranging from 28.7 (95% CI, 23.4-34.9) to 29.8 (95% CI, 24.3-36.3) per 100 000 women. Compared with the US, incidence rates were highest in RMI (rate ratio, 5.7 [95% CI, 4.7-6.8] to 8.2 [95% CI, 6.7-9.9]) and FSM (rate ratio; 2.8; 95% CI, 2.3-3.4). Of all cases in the USAPI, 213 (68.2%) were diagnosed at a late stage.Conclusions and RelevanceIn this cross-sectional study, cervical cancer remained a major public health issue in some USAPI, with RMI reporting the highest incidence rates. The findings suggest that improvements in human papillomavirus vaccination and cancer screening coverage through efforts tailored to the unique geographic, sociocultural, economic, and health care landscape of the USAPI may reduce the burden of cervical cancer.
Chronic Rhinosinusitis and Mental Health
Authors: Khan Najm S. , Gajula Meher , Goehring Lexi , Takashima Masayoshi , Dhanda Aatin , Syed Tariq A. , McCoul Edward D. , Vrabec Jeffrey T. , Ramanathan Murugappan , Hu Renjie , Ahmed Omar G. 
Published: September 2024

ImportanceChronic rhinosinusitis (CRS) has been associated with anxiety and depression, but the association of socioeconomic factors and temporality has yet to be fully explored.ObjectiveTo determine the bidirectional risk of anxiety and depression for patients with CRS.Design, Setting, and ParticipantsThis retrospective cohort study of the National Institutes of Health All of Us database from January 1, 2008, to December 31, 2018, included 2 cohorts of adult patients with and without CRS. The data were analyzed from July 1, 2023, through April 1, 2024. Patients were classified as having CRS if they had at least 2 diagnoses during the study period. Those with a diagnosis of CRS before the study period were excluded. Patients were propensity score matched (1:5) with patients without CRS for age, sex, race, and annual household income.Main Outcomes and MeasuresThe primary outcome was the development of anxiety and depression. Patients with CRS were counted as having the primary outcome if it occurred after the criteria for CRS diagnosis were fulfilled. Multivariate logistic regression and survival analysis were performed to determine the odds ratios (ORs) and hazard ratios (HRs) of anxiety and depression. A secondary survival analysis determined the risk of developing CRS between patients with anxiety and depression and controls.ResultsAmong 33 732 patients (23 382 [69.3%] female individuals; 510 [1.5%] Asian, 6002 [17.9%] Black or African American, 576 [1.7%] multiracial, and 26 036 [77.2%] White individuals), there were 28 110 controls and 5622 patients with CRS. Along with higher odds of having anxiety (OR, 4.39; 95% CI, 3.95-4.87) and depression (OR, 2.04; 95% CI, 1.86-2.24), patients with CRS were at an increased risk of developing anxiety (HR, 2.79; 95% CI, 2.47-3.15) and depression (HR, 1.40; 95% CI, 1.27-1.55) compared with controls. Additionally, patients with anxiety (HR, 2.37; 95% CI, 2.18-2.57) and depression (HR, 1.59; 95% CI, 1.46-1.72) were at an increased risk of developing chronic rhinosinusitis compared with controls.Conclusions and RelevanceIn this population-based cohort study of adults with and without CRS, a bidirectional association between common psychiatric disorders and CRS was observed. Physicians and health care clinicians who treat patients with anxiety, depression, and CRS should be vigilant regarding these risks and screen patients appropriately.
High Voltage, Long Cycling Organic Cathodes Rendered by In Situ Electrochemical Oxidation Polymerization
Authors: Zhou Jiarong , Zheng Biao , Huang Xingying , Zhou Wang , Sun Caihong , Sun Xiujuan , Zhang Tao , Huang Zhifeng , Tan Songting , Liu Jilei , Gao Ping 
Published: September 2024

AbstractOrganic electrode materials have attracted considerable attention for electrochemical energy storage due to their abundance of elements, tunable molecular structure, and sustainability. However, the application of organic batteries is plagued by their high solubility and low discharge potential, resulting in poor cycle life and low energy density. Here, ([5,15‐bis(4‐diphenylaminophenyl) porphyrin] Cu(II) (CuDTNP) and [5,10,15,20‐tetrakis(4‐diphenylaminophenyl)porphyrin] Cu(II) (CuFTNP)) as cathodes for organic‐lithium batteries are presented. A highly stable cathode (CuFTNP) with high potential (3.82 V) is achieved by introducing triphenylamine groups in the meso‐position of the porphyrin complex due to the self‐polymerization behavior and anion storage during the electrochemical reaction. Benefiting from triphenylamine groups, higher diffusion coefficients (3.93 × 10−9 cm2 s−1) is achieved, ascribed to the enhanced conjugated structure. As a result, a power density of 34.2 kW kg−1, and excellent cycling stability up to 40 000 cycles are achieved. This cathode can also be extended in organic‐sodium batteries with good cycling stability (600 cycles) and high potential (3.60 V). The charge storage mechanism and polymerization behavior are evidenced by in situ FTIR and in situ Raman characterization. This study will provide inspiration for the development of next‐generation organic cathodes with high potential, high power density, and long‐cycle life through molecular design.
Suppressing the vdW Gap‐Induced Tunneling Barrier by Constructing Interfacial Covalent Bonds in 2D Metal–Semiconductor Contacts
Authors: Shan Wenchao , Shi Anqi , Xin Zhengyang , Zhang Xiuyun , Wang Bing , Li Yongtao , Niu Xianghong 
Published: September 2024

Abstract2D metal and semiconductor materials provide a promising solution to realize Ohmic contacts by suppressing the strong Fermi level pinning (FLP) effect due to without dangling bonds. However, the 2D metal‐semiconductor Van der Waals (vdW) interfaces induce an inevitable tunnel barrier, significantly restraining the injection of charge carriers into the conduction channel. Herein, by replacing the vdW bond with the covalent bond in interfaces, the Ohmic and tunneling‐barrier‐inhibition contacts are realized simultaneously based on the 2D XSi2N4 (X = Cr, Hf, Mo, Ti, V, Zr) semiconductor and the 2D Mxene metal family. Taking 60 2D Mxene‐XSi2N4 contacts as examples, although the vdW‐type contacts exhibit Ohmic contacts, the tunneling probability (PTB) can be as low as 0.4%, while the PTB can increase to 88.09% by removing the Mxene terminations at the adjacent interface to form the covalent bond. The weak FLP and Ohmic contacts are retained at covalent bond interfaces since the outlying Si─N sublayer protects the band‐edge electronic states of XSi2N4 semiconductors. This work provides a straightforward strategy for advancing high‐performance and energy‐efficient 2D electronic nanodevices.
Reconfigurable Exotic Liquid Crystal Elastomer “Smart” Surfaces via Hot Embossing
Authors: Yue Lansong , Lugger Sean J. D. , Debije Michael G. , Schenning Albert P. H. J. 
Published: September 2024

AbstractSmart surfaces, distinguished by their dynamic responses to environmental changes, may enhance the functionality, interactivity, and efficiency of materials and devices. Liquid crystal elastomers (LCEs) are ideal candidates for creating smart surfaces, allowing reversible topographical changes in response to environmental stimuli. However, traditional thermoset LCE preparation methods require complex manufacturing processes, including photopolymerization, and the resulting surfaces (often pillars) are nonreprogrammable and nonrecyclable. In this work, hot embossing is used in combination with a thermoplastic LCE for creating self‐healing and reprogrammable exotic surfaces capable of reversibly responding to environmental stimuli, significantly simplifying fabrication. It is demonstrated that hot embossing can be effectively applied to fabricate surfaces with arrays of pillars, cones, tubes, or mushroom shapes. The exotic surface structures exhibit reversible and programmable shape changes in response to heat and can be erased and rewritten to alternate complex topographies. As an additional feature, the LCE can be recycled and reused to create photo‐responsive surface topographies that can be spatiotemporally addressed by light. Light‐responsive LCE surfaces are prepared by incorporating a photothermal dye without loss of reconfigurability. Demonstrators are fabricated such as locally controlled object movement on a surface by light.
Transverse‐Asymmetric Electrode Structure Design to Eliminate Charge Transfer Loss for Enhancing Output Performance of Sliding Mode TENG
Authors: Li Gui , An Shanshan , Wang Ping , Xiong Shengyang , Wang Jian , Xu Shuyan , Wu Huiyuan , Li Kaixian , Li Wen , Tong Lin , Hu Chenguo 
Published: September 2024

AbstractSliding mode triboelectric nanogenerators (S‐TENG) have been validated as a simple and efficient mechanical energy harvesting technology in low frequency for constructing self‐powered systems. However, the charge invalid transfer in the S‐TENG leads to its output energy loss, which has not been addressed by researchers in this field. Herein, a novel transverse‐asymmetric electrode structure sliding TENG (TAE‐TENG) is proposed, where the specific asymmetric bottom electrode configuration distinguishes it from the previously reported S‐TENGs. This design can be equivalent to a hybrid model, consisting of two units, a sliding mode TENG with blank area and a freestanding mode TENG with a shielding electrode, which effectively eliminates the charge transfer loss and enhances the output performance. The insight mechanism of charge transfer in each operation process is analyzed. The TAE‐TENG achieves 1.42 µC output charge, 1.97‐fold as that of the conventional S‐TENG (0.72 µC) with equivalent dimensions, and also exhibits more sustained and higher current waveforms. The output charge, root‐mean‐square (RMS) current, and average power of the rotation‐TAE‐TENG at 60 rpm are 3.05 µC, 97.50 µA and 44.02 mW, respectively. This work provides a physical mechanism of charge transfer in sliding TENG and an effective method to improve its output energy.
Se‐Rich Functionalized FeSx Hollow Nanospheres for Accelerated and Long‐Lasting Sodium Storage
Authors: Haruna Baffa , Wang Lina , Hu Xiang , Luo Guangfu , Muhammad Mujtaba Aminu , Liu Yangjie , Yu Jiaqi , Abdel‐Aziz Ahmed , Bao Hongli , Wen Zhenhai 
Published: September 2024

AbstractTransition metal sulfides are emerging as promising anode materials for sodium‐ion batteries (SIBs) due to their high theoretical capacity and low cost, their practical application yet face critical issues of sluggish kinetics and poor cycling stability. In this study, a reliable approach is introduced to overcome these challenges by fabrication of Se0.75‐Fe1‐xS0.25@SC hollow nanospheres thanks to the enriched robust Fe─S─C, C─S, and C─Se bonding, which greatly benefit for enhancing both reaction kinetics and structural stability. Kinetic study combining with in situ characterization reveals that the incorporation of rich‐Se into FeSx induces the formation of cationic Fe and Se vacancies, leading to abundant sites and optimized path for sodium storage. Density functional theory calculations also demonstrate how Se‐rich engineering weakens carbonaceous polar C─S─Fe bonds and accelerates reaction dynamics. The as‐prepared Se0.75‐Fe1‐xS0.25@SC can deliver a high reversible capacity of 515 mAh g−1 at 2 A g−1 over 1250 cycles and achieve superior rate capability with maintaining capacity of 418 mAh g−1 at 10 A g−1. This work pioneers the concept of vacancy‐rich functionalized nanostructures, offering a new pathway for designing advanced electrode materials for energy storage devices.
Refining O3‐Type Ni/Mn‐Based Sodium‐Ion Battery Cathodes via “Atomic Knife” Achieving High Capacity and Stability
Authors: Yuan Tao , Li Pengzhi , Sun Yuanyuan , Che Haiying , Zheng Qinfeng , Zhang Yixiao , Huang Shuai , Qiu Jian , Pang Yuepeng , Yang Junhe , Ma Zi‐Feng , Zheng Shiyou 
Published: September 2024

AbstractThe O3‐type NaNi0.5Mn0.5O2 (NM) layered cathode in sodium ion batteries (SIBs) undergoes structural distortion and capacity degradation during cycling, which seriously hinders its practical application. Herein, lanthanum (La) is employed as a dopant in O3‐NaNi0.5Mn0.5‐xLaxO2 (NML) cathodes, which triggered an “atomic knife” effect, reducing particle size, and stabilizing crystal structure. The larger La ions generated structural strain during grain growth at high temperatures, hindering the movement of grain boundaries and refining the size of NML particles. Comprehensive characterizations illuminated La doping‐induced atomic site occupancy and phase transformations within NML. A competitive phase formation between layered NML and perovskite LaMnO3 (LMO) is observed. Spontaneously formed perovskite LMO provides surface protection. Moreover, strong La─O bonds expand the Na interlayer spacing, enhancing Na+‐ion diffusion. Consequently, NML cathodes exhibit superior long‐term cycling stability and ultrahigh rate capacities compared to pristine NM cathode and most currently reported layered cathodes for SIBs.
Dye‐Based Fluorescent Organic Nanoparticles, New Promising Tools for Optogenetics
Authors: Lesas Jérémy , Bienvenu Thomas C.M. , Kurek Eleonore , Verlhac Jean‐Baptiste , Grivet Zoé , Têtu Maude , Girard Delphine , Lanore Frédéric , Blanchard‐Desce Mireille , Herry Cyril , Daniel Jonathan , Dejean Cyril 
Published: September 2024

AbstractDye‐based fluorescent organic nanoparticles are a specific class of nanoparticles obtained by nanoprecipitation in water of pure dyes only. While the photophysical and colloidal properties of the nanoparticles strongly depend on the nature of the aggregated dyes, their excellent brightness in the visible and in the near infrared make these nanoparticles a unique and versatile platform for in vivo application. This article examines the promising utilization of these nanoparticles for in vivo optogenetics applications. Their photophysical properties as well as their biocompatibility and their capacity to activate Chrimson opsin in vivo through the fluorescence reabsorption process are demonstrated. Additionally, an illustrative example of employing these nanoparticles in fear reduction in mice through closed‐loop stimulation is presented. Through an optogenetic methodology, the nanoparticles demonstrate an ability to selectively manipulate neurons implicated in the fear response and diminish the latter. Dye‐based fluorescent organic nanoparticles represent a promising and innovative strategy for optogenetic applications, holding substantial potential in the domain of translational neuroscience. This work paves the way for novel therapeutic modalities for neurological and neuropsychiatric disorders.
In Vivo Interactions of Nucleic Acid Nanostructures With Cells
Authors: Xiao Yu , Liang Zhihui , Shyngys Moldir , Baekova Aiana , Cheung Suen , Muljadi Mathias Billy , Bai Qianqian , Zeng Lula , Choi Chung Hang Jonathan 
Published: September 2024

Abstract
Nucleic acid nanostructures, derived from the assembly of nucleic acid building blocks (e.g., plasmids and oligonucleotides), are important intracellular carriers of therapeutic cargoes widely utilized in preclinical nanomedicine applications, yet their clinical translation remains scarce. In the era of “translational nucleic acid nanotechnology”, a deeper mechanistic understanding of the interactions of nucleic acid nanostructures with cells in vivo will guide the development of more efficacious nanomedicines. This review showcases the recent progress in dissecting the in vivo interactions of four key types of nucleic acid nanostructures (i.e., tile‐based, origami, spherical nucleic acid, and nucleic acid nanogel) with cells in rodents over the past five years. Emphasis lies on the cellular‐level distribution of nucleic acid nanostructures in various organs and tissues and the cellular responses induced by their cellular entry. Next, in the spirit of preclinical translation, this review features the latest interactions of nucleic acid nanostructures with cells in large animals and humans. Finally, the review offers directions for studying the interactions of nucleic acid nanostructures with cells from both materials and biology perspectives and concludes with some regulatory updates.
Temperature Promotes Photoluminescence in Lanthanide‐Doped 3D Ceramic Microarchitectures
Authors: Rosero‐Arias Cristian , Vásquez Geraldo Cristian , Davila‐Montero Noelia Geraldine , Winczewski Jedrzej , Mei Bastian , De Leon Israel , Maestre David , Gardeniers Han , Aguirre‐Soto Alan , Susarrey‐Arce Arturo 
Published: September 2024

AbstractTwo‐photon lithography (TPL) is a powerful technique for creating 3D microarchitectures. Applied to high‐refractive‐index materials like ZrO2, it promises advanced optics. This is the case of ZrO2 host matrixes in combination with luminescent dopants. However, due to the nonideal crystallinity attained to the TPL pre‐ceramic replica from a custom‐made photoresin, the emission of lanthanide (Ln) dopants in ZrO2 microarchitectures can be suboptimal. However, crystallinity exacerbated by annealing can promote Ln‐emission, thereby enabling the integration of ceramic micro‐optic into a low‐temperature process. This work presents a photoresin containing a metal‐organic monomer tailored for TPL, enabling the fabrication of Ln‐doped tetragonal ZrO2 (t‐ZrO2) microarchitectures. The emission properties of Ln‐doped microarchitectures with trivalent Ln ions (Ln3+), i.e., Yb3+ (2.5 mol%), Er3+ (0.35 mol%), and Tm3+ (0.35 mol%) are studied. The results demonstrate that Ln emission is absent when annealing the microarchitectures at 600 °C. Annealing at 750 °C activates Ln3+ emissions, including 2F5/2–2F7/2 (infrared), 4S3/2–4I15/2 (green), and 3H4–3F6 (near‐infrared) transitions corresponding to Yb, Er, and Tm species. Transmission electron microscopy (TEM) confirms that t‐ZrO2 crystallinity becomes more prominent at 750 °C, demonstrating the promotion of Ln emissions upon thermal treatment and underscoring the role of crystalline in TPL micro‐optical ceramics.
Surface‐Enhanced Raman Scattering and Photothermal Effects on Optoplasmonic Nanofibers
Authors: Wallace Gregory Q. , Ringe Emilie , Faulds Karen , Graham Duncan , Masson Jean‐François 
Published: September 2024

AbstractWhen decorated with plasmonic nanoparticles, pulled optical nanofibers are compatible with plasmonic techniques enabling the ability to probe microenvironments with high spatial and temporal resolution. Although the nanofibers exhibit excellent compatibility for biological samples including cells and tissues, the underlying interactions between the dielectric fiber, plasmonic nanoparticles, and the incident light have been minimally explored. It is shown that the complex coupling of optical and plasmonic properties within the nanofiber strongly influences both the surface‐enhanced Raman scattering (SERS) and photothermal capabilities. Through a combination of experimental results and simulated electric field distributions and spectra it is demonstrated that, although the nanofibers may be homogeneously decorated with gold nanoparticles, the optical effects spatially differ. Specifically, the SERS performance varies periodically based on the diameter of the nanofiber, which is associated with ring resonator modes, while the photothermal effects are more homogeneous over the same diameters, highlighting differences in optoplasmonic properties at this length scale. Through understanding these effects, it may become possible to control temperatures and SERS properties to evaluate processes with micrometric spatial resolution, such as the analytes secreted during temperature‐induced death of single cells.
Visible‐Light‐Induced C−H Silylation of Azauracils with Hydrosilanes
Authors: Yu Yongqi , You Mengdan , Yu Jiajia , Kong Weiguang , Zhang Chunyan , Bai Jinjin , Li Wenguang , Li Ting 
Published: September 2024

AbstractC−H silylation of azauracils was developed via the combination of organic photoredox and hydrogen atom transfer (HAT) catalysis. Using 1,2,3,5‐tetrakis(carbazol‐9‐yl)‐4,6‐dicyanobenzene (4CzIPN) as the photocatalyst, quinuclidine as the HAT catalyst, and silanes as the silyl radical source, a variety of silylated azauracils were synthesized in 43–87% yield. Moreover, pyrazinone, cinnolinone, and chromone were also compatible with this catalytic system. The reaction is suitable for late‐stage functionalization of drugs and complex molecules, and the transformation can be easily scaled up to gram level. Mechanistic studies suggest that the silylation reaction is likely to proceed through a radical mechanism.