bluuebunny/crossref_metadata_2025_split huggingface dataset:
Refinements of Strichartz estimates on tori and applications
Authors: Schippa Robert 
Published: September 2024

Abstract
We show trilinear Strichartz estimates in one and two dimensions on frequency-dependent time intervals. These improve on the corresponding linear estimates of periodic solutions to the Schrödinger equation. The proof combines decoupling iterations with bilinear short-time Strichartz estimates. Secondly, we use decoupling to show new linear Strichartz estimates on frequency dependent time intervals. We apply these in case of the Airy propagator to obtain the sharp Sobolev regularity for the existence of solutions to the modified Korteweg–de Vries equation.
GlyCompute: towards the automated analysis of protein N-linked glycosylation kinetics via an open-source computational framework
Authors: Flevaris Konstantinos , Kotidis Pavlos , Kontoravdi Cleo 
Published: September 2024

Abstract
Understanding the complex biosynthetic pathways of glycosylation is crucial for the expanding field of glycosciences. Computer-aided glycosylation analysis has greatly benefited in recent years from the development of tools found in web-based portals and open-source libraries. However, the in silico analysis of cellular glycosylation kinetics is underrepresented in current glycoscience-related tools and databases. This could be partly attributed to the limited accessibility of kinetic models developed using proprietary software and the difficulty in reliably parameterising such models. This work aims to address these challenges by proposing GlyCompute, an open-source framework demonstrating a novel, streamlined approach for the assembly, simulation, and parameterisation of kinetic models of protein N-linked glycosylation. Specifically, given one or more sets of experimentally observed N-glycan structures and their relative abundances, minimum representations of a glycosylation reaction network are generated. The topology of the resulting networks is then used to automatically assemble the material balances and kinetic mechanisms underpinning the mathematical model. To match the experimentally observed relative abundances, a sequential parameter estimation strategy using Bayesian inference is proposed, with stages determined automatically based on the underlying network topology. The proposed framework was tested on a case study involving the simultaneous fitting of the kinetic model to two protein N-linked glycoprofiles produced by the same CHO cell culture, showing good agreement with experimental observations. We envision that GlyCompute could help glycoscientists gain quantitative insights into the effect of enzyme kinetics and their perturbations on experimentally observed glycoprofiles in biomanufacturing and clinical settings.

Graphical Abstract
“There is a life before and after cancer”: experiences of resuming life and unmet care needs in stage I and II melanoma survivors
Authors: Kamminga N. C.W. , Kievits J. E.C. , Wakkee M. , Loon S. G.W. van , Joosen M. C.W. , Verver D. , Munte K. , Plaisier P. W.P. , Rietjens J. A.C. , Nijsten T. E.C. , Lugtenberg M. 
Published: September 2024

AbstractAlthough the largest increase in melanoma incidence is observed for localised melanoma, little research has been done on its impact. Despite favourable prognoses and relatively short treatment trajectories, diagnosis and treatment may significantly impact life post-treatment. Therefore, the aim of this study was to gain an in-depth understanding of stage I and II melanoma survivors’ experiences resuming life after treatment and their associated survivorship care (SSC) needs. A qualitative focus group study was conducted with 18 stage I or II melanoma survivors, divided over three focus groups with 6 survivors each. Transcripts were analysed through thorough thematic content analysis, using multiple phases of coding. In resuming life, survivors experienced profound initial impacts of disease and treatment, fed by a perceived lack of knowledge and underestimation of melanoma. They faced unexpected physical and emotional effects post-surgery, experiencing mixed feelings from relief to fear and uncertainty. Survivors felt misunderstood, had to adjust their lives, and managed personal and external expectations while experiencing a positive shift in life perspective, leading to a notable difference in life before and after cancer. In terms of SSC needs, survivors stressed the need for tailored information, accessible resources, patient-centered follow-up, and supportive care addressing the total impact of disease and treatment. These findings highlight the importance of improving melanoma awareness and providing holistic SSC not only to advanced, but also to localised melanoma survivors. A tailored survivorship care plan could facilitate access to information and supportive care, helping patients resume their lives.
Limitations and perspectives of the novel salivary test for endometriosis: an open web-based survey study of German gynecologic healthcare providers
Authors: Nigdelis Meletios P. , Doerk Merle , Burghaus Stefanie , Sillem Martin , Hamoud Bashar Haj , Solomayer Erich-Franz , Olmes Gregor Leonhard 
Published: September 2024

Abstract
Introduction
The description of a salivary miRNA signature for endometriosis has led to the development of a non-invasive diagnostic test. Current healthcare provider practices regarding the test remain uncaptured. The application of this test in practice was examined in a web-based survey, with the aim to provide their opinions on it.

Methods
We conducted an open web-based survey study between November 2023 and January 2024. Members of the German society of gynecologic endoscopy (Arbeitsgemeinschaft gynäkologische Endoskopie, AGE), society of endometriosis (Arbeitsgemeinschaft Endometriose, AGEM), and the endometriosis research foundation (Stiftung Endometriose Forschung, SEF) were contacted per e-mail twice. Participants’ data were anonymized. Differences in responses based on self-reported expertise in the field (basic knowledge, specialized knowledge, expert) were assessed using the χ2-test or Fisher’s exact test. Statistical significance was set as p < 0.05.

Results
In total 141 of 190 respondents completely responded to the survey (> 75% of the questions of the survey). Twenty-one physicians reported having experience with the test, while most participants had at least specialized knowledge on the field (112/141). In terms of specific questions, more than 90% found the costs high; almost 85% did not believe that the test replaces standard diagnostic tools (histology, clinical examination, and sonography). Eighty-six providers supported the use of the test in adolescents. Gynecologists with basic knowledge had a more positive attitude compared with more experienced ones in terms of usefulness (Fisher’s exact test, p < 0.001). Significant differences were demonstrated between expertise groups regarding (not only) applicability in adolescents (Fisher’s exact test, p = 0.004), and using the test for screening purposes (χ2-test, p = 0.002).

Discussion
Despite the promising benefits of a salivary test for endometriosis, German healthcare providers would not change current practices. Nevertheless, less experienced colleagues were more positive towards the test.
K2P2.1 channels modulate the pH- and mechanosensitivity of pancreatic stellate cells
Authors: Rugi Micol , Hofschröer Verena , Pethő Zoltán , Soret Benjamin , Loeck Thorsten , Schwab Albrecht 
Published: September 2024

AbstractPancreatic stellate cells (PSCs) are central in the development of acute pancreatitis and tumor fibrosis in pancreatic ductal adenocarcinoma (PDAC). Fibrosis and a unique pH landscape represent characteristic properties of the PDAC microenvironment. Mechanosensitive ion channels are involved in the activation of PSCs. Among these channels, K2P2.1 has not yet been studied in PSCs. K2P2.1 channels are pH- and mechanosensitive. We confirmed K2P2.1 expression in PSCs by RT-qPCR and immunofluorescence. PSCs from K2P2.1+/+ and K2P2.1−/− mice were studied under conditions mimicking properties of the PDAC microenvironment (acidic extracellular pH (pHe), ambient pressure elevated by + 100 mmHg). Migration and the cell area were taken as surrogates for PSC activation and evaluated with live cell imaging. pHe-dependent changes of the membrane potential of PSCs were investigated with DiBAC4(3), a voltage-sensitive fluorescent dye. We observed a correlation between morphological activation and progressive hyperpolarization of the cells in response to changes in pHe and pressure. The effect was in part dependent on the expression of K2P2.1 channels because the membrane potential of K2P2.1+/+ PSCs was always more hyperpolarized than that of K2P2.1−/− PSCs. Cell migration velocity of K2P2.1+/+ cells decreased upon pressure application when cells were kept in an acidic medium (pHe 6.6). This was not the case in K2P2.1−/− PSCs. Taken together, our study highlights the critical role of K2P2.1 channels in the combined sensing of environmental pressure and pHe by PSCs and in coordinating cellular morphology with membrane potential dynamics. Thus, K2P2.1 channels are important mechano-sensors in murine PSCs.
White matter connectivity linked to novel word learning in children
Authors: Ekerdt Clara , Menks Willeke M. , Fernández Guillén , McQueen James M. , Takashima Atsuko , Janzen Gabriele 
Published: September 2024

AbstractChildren and adults are excellent word learners. Increasing evidence suggests that the neural mechanisms that allow us to learn words change with age. In a recent fMRI study from our group, several brain regions exhibited age-related differences when accessing newly learned words in a second language (L2; Takashima et al. Dev Cogn Neurosci 37, 2019). Namely, while the Teen group (aged 14–16 years) activated more left frontal and parietal regions, the Young group (aged 8–10 years) activated right frontal and parietal regions. In the current study we analyzed the structural connectivity data from the aforementioned study, examining the white matter connectivity of the regions that showed age-related functional activation differences. Age group differences in streamline density as well as correlations with L2 word learning success and their interaction were examined. The Teen group showed stronger connectivity than the Young group in the right arcuate fasciculus (AF). Furthermore, white matter connectivity and memory for L2 words across the two age groups correlated in the left AF and the right anterior thalamic radiation (ATR) such that higher connectivity in the left AF and lower connectivity in the right ATR was related to better memory for L2 words. Additionally, connectivity in the area of the right AF that exhibited age-related differences predicted word learning success. The finding that across the two age groups, stronger connectivity is related to better memory for words lends further support to the hypothesis that the prolonged maturation of the prefrontal cortex, here in the form of structural connectivity, plays an important role in the development of memory.
Factors affecting wild boar damage and countermeasure effectiveness: a case study in a regional park located in a mountainous area
Authors: Tamura Shota , Yokoyama Makoto , Bamrungkhul Settawut , Ngamsiriudom Tarnrawee , Katano Yuki , Kanemoto Hiroki , Chiba Yuria , Hirano Kazuki , Mizusawa Katsuya , Goto Taku , Nishimura Jumpei , Matsuura Michihiro , Migitera Tomoya , Yamaga Riki , Araki Ryota , Kitazawa Masaki , Shiromoto Daiki , Sogame Isho , Fukuda Momoka , Yamamoto Yuki , Tanaka Takahiro 
Published: September 2024

AbstractIn recent years, the habitat distribution of wild boar has expanded in Japan, and the damage caused by wild boar has been significantly increased. In Bingo Sports Park, a regional park, wild boar damage has also been increasingly severe. To take effective measures, it is necessary to understand where wild boars enter the park, how they move through it, and where the damage is caused. Therefore, this study examines both environmental characteristics inside and outside the park and behavioral characteristics of wild boar using drones, sensor technology and GIS, and then clarifies the main factors contributing to wild boar damage based the logistic regression analysis. In addition, countermeasures such as installing electric fences and repellents were taken, and their effectiveness was verified. There were three main findings. First, the behavioral pattern of wild boars was found to be likely to enter from valleys and usually move on roads in the park. Second, the probability of occurring wild boar damage is higher in areas closer to roads and valleys with more natural cover. Third, the countermeasures have a significant effect on reducing wild boar damage since the amount of damage in the Multi-purposed square installed countermeasure was too small.
The efficacy of screening with FDG-PET/CT for distant metastases in breast cancer patients scheduled for neoadjuvant systemic therapy
Authors: Gunster Jetske L. B. , van Duijnhoven Frederieke H. , Scholten Astrid N. , Smorenburg Carolien H. , Dezentje Vincent O. , van Olmen Josefien P. , Marijnen Corrie A. M. , Stokkel Marcel P. M. , Loo Claudette E. , Schrijver A. Marjolein 
Published: September 2024

Abstract

Purpose
This study aims to identify which breast cancer patients benefit from the routine use of FDG-PET/CT in a large cohort of patients scheduled for neoadjuvant systemic therapy (NST).

Methods
A total of 1337 breast cancer patients eligible for NST were identified from a retrospective database between 2011 and 2020 at a single tertiary care hospital. All patients underwent staging with FDG-PET/CT prior to NST. The incidence and extent of asymptomatic distant metastases in different patient subgroups were determined, as well as the impact on treatment. Logistic regression analysis was used to identify prognostic patient and tumor characteristics.

Results
FDG-PET/CT detected distant metastases in 109 patients (8%). Initial clinical stage was a prognostic factor for the presence of distant metastases, with a significantly higher risk for stage 2b and 3 as opposed to lower stages (p < 0.001). The incidence of distant metastases was 3% (4/125) for stage 1, 2% (8/534) for stage 2a, 7% (24/354) for stage 2b and 23% (73/324) for stage 3. Other characteristics such as age, tumor subtype, histological type and grade were not correlated with the risk of distant metastases. Among the subset of patients with distant metastases, 46% received palliative treatment, while the remaining 54% were diagnosed with oligometastatic breast cancer and were treated with curative intent.

Conclusion
The results of the current study support the routine use of FDG-PET/CT for the detection of distant metastases in breast cancer patients with initial clinical stage 2b and 3, regardless of tumor subtype.
Growing liveable cities: an indicators study of Melbourne’s fast-growing metropolitan area
Authors: An Aaron 
Published: September 2024

AbstractBuilding liveable cities is challenging; ensuring we keep building liveable cities with growing populations is more difficult, but it's a task that we can tackle together. The Metropolitan Growth Area Councils (MGACs) in Greater Melbourne are experiencing rapid growth, which presents development opportunities and challenges for building liveable communities. This article examines the correlations between MGACs and other metropolitan councils on key indicators such as population, council representation, household characters, education, employment, transport, and safety. It concludes that MGACs tend to have larger populations, more children, younger communities, and lower mortgage payments but are less likely to own their homes outright, more commuters by car and large gaps in community infrastructure such as schools and libraries. Crimes such as burglaries, housebreaking, and arson are also problems. As decision-makers, urban planners, community stakeholders, and researchers involved in urban development and community planning, it is crucial to target resources at these challenges to make communities in growth areas more liveable.
Speed of Sound Measurements of R-1130(E) and an Azeotropic Blend of R-1336mzz(Z)/1130(E)
Authors: Rowane Aaron J. 
Published: September 2024

AbstractSound speed data measured using a dual-path pulse-echo instrument are reported for pure trans-1,2-dichloroethene (R-1130(E)) and an azeotropic blend of cis-1,1,1,4,4,4-hexafluorobutene (R-1336mzz(Z)) and R-1130(E) with a composition of 74.8 mass % R-1336mzz(Z) with the balance being R-1130(E). The azeotropic blend of R-1336mzz(Z)/1130(E) is classified as R-514A in ANSI/ASHRAE standard 34. Liquid phase speed of sound data are reported from just above the saturation pressure of pure R-1130(E) or the bubble point pressure of R-514A to a maximum pressure of 26.7 MPa. The relative combined expanded uncertainty in the speed of sound varies from 0.032 % to 0.148 % with the greatest deviations occurring at the lowest sound speeds. At present, no reference Helmholtz-energy-explicit equation of state (EOS) is available for R-1130(E). Therefore, the reported data for pure R-1130(E) are compared to an extended corresponding states (ECS) model. Deviations between the pure R-1130(E) sound speed data and the ECS model were found to be consistently negative ranging between − 4.1 % and − 3.5 %. The R-514A data are compared to a multifluid model inclusive of the established reference Helmholtz-energy-explicit EOS for R-1336mzz(Z) and ECS model for R-1130(E) with estimated binary interaction parameters. Deviations between the experimental speed of sound data and the multifluid model were also found to be consistently negative. However, deviations from the multifluid model were found to be as great as − 17.1 %. The large deviations from the ECS model and multifluid model underscore the need for a robust Helmholtz-energy-explicit EOS for R-1130(E).
Working less for longer: unintended effects of longevity adjustment of retirement age
Authors: Hougaard Jensen Svend E. , Sveinsson Thorsteinn Sigurdur , Sousa Duarte Miguel 
Published: September 2024

AbstractUsing a standard macro model with overlapping generations in the manner of Blanchard–Yaari, we show that by broadening the labour supply on the extensive margin through longevity adjustment of the statutory retirement age, labour supply is likely to decrease on the intensive margin. However, this backlash effect depends on the specific design of the pension system. It is significantly higher under a pay-as-you-go scheme with fixed benefits compared to a pay-as-you-go scheme with fixed contributions and a fully funded scheme based on voluntary savings. The findings have implications for responses to the fiscal and macroeconomic challenges raised by an ageing population.
The Moderating Effect of Sex on Autistic Trait Emotional Intelligence, Alexithymia, and Empathy
Authors: Cargill Mary Isaac , Lerner Matthew D. , Kang Erin 
Published: September 2024

AbstractAutism spectrum disorder (ASD) is associated with differences in social communication, and these differences are related to trait emotional intelligence (TEI), alexithymia, and empathy. Autism is known to present differently in males and females, but research on sex differences in TEI, alexithymia, and empathy is largely relegated to non-autistic people. Therefore, the current research sought to explore individual relationships between autistic characteristics and TEI, alexithymia, and empathy, as well as the possible influence of sex in these relationships. In the current study, autistic and non-autistic adults reported on their autistic characteristics, TEI, alexithymia, and empathy. Based on previous research, it was hypothesized that more autistic characteristics would be associated with less TEI, more alexithymia, and less empathy, and that these relationships would be more prominent amongst males. More autistic characteristics were associated with greater challenges across the three areas of interest. However, only the relationship between TEI and autistic characteristics was moderated by sex, such that males demonstrated higher support needs related to TEI than females. Results from this analysis indicate that adults with more autistic characteristics, regardless of diagnostic status, demonstrate differences in TEI, alexithymia, and empathy. The current analysis may offer additional context to the evolving understanding of empathy and autism by suggesting that TEI and alexithymia could account for differences in empathy. Moreover, sex seems to play a role in the relationship between autistic characteristics and TEI such that differences are especially prominent for males.
Prevention and Reduction of Anxiety in Autistic Preschoolers Through an Autism-Specific Parent-Mediated Intervention: A Pilot Randomised Controlled Trial Evaluating Short and Longer Term Outcomes
Authors: Adams Dawn , Malone Stephanie , Dargue Nicole , Keen Deb , Rodgers Jacqui , Simpson Kate , Wicks Rachelle , Bullot Ashleigh , Rapee Ron 
Published: September 2024

AbstractAnxiety is a common co-occurring condition for autistic preschoolers. Whilst there has been extensive research evaluating anxiety prevention/reduction interventions for neurotypical preschoolers, such research is limited for autistic children. Fifty-seven parents of autistic 4–5-year olds, with varying levels of anxiety, participated in a randomised controlled trial of an autism-specific, parent-mediated intervention (CLK-CUES) to prevent or reduce anxiety in autistic preschoolers. Baseline, short-term (post-intervention) and longer term (12 months follow-up) assessments included child anxiety (ASC-ASD-P and PAS-R), intolerance of uncertainty, and parent well-being. (Trial registration ACTRN12620001322921). There were no reports of harmful effects of the intervention or trial. Linear mixed models show a significant group x time interaction for ASC-ASD-P Total score and the Uncertainty subscale with medium and large effect sizes. Post-hoc analyses show a significant decline for only the intervention group in anxiety (specifically, anxiety around uncertainty) from pre-post intervention, maintained at one year follow-up. There was no change on the PAS-R or other ASC-ASD-P subscales. CLK-CUES shows promise as a way to prevent and reduce anxiety in young autistic children, specifically anxiety related to uncertainty. Trials with larger samples are warranted. Findings also highlight the importance of using measures designed for autistic children.