bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Centralized Platform of Open Government Data as Support to Applications in the Smart Cities Context
Authors: Vieira Ianegitz , Alvaro Alexandre 
Published: January 2018

Purpose - This article aims to present the design, implementation and validation of an Open Government Data Platform.
Design/methodology/approach - The development of the work took place in 4 steps: survey of the state of the art of literature; design of the open government data platform; implementation and testing of the platform; and, finally, experimental validation with a group of students of a Brazilian university.
Findings - Through the validations of the platform can be noted advantages with respect to the productivity gain for the development of solutions, in the context of Smart Cities, using the proposed platform.
Research limitations/implications - The experiment was developed in a controlled manner in the context of a Brazilian university. In addition, there is a need to capture more data from other town hall to store on the platform.
Originality/value - The centralized storage of open government data is a tool that enables the decision-making of public managers as well as the beginning of the transformation of the present cities to a smart city.
MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-ALL
Authors: Zhou Mi , Zhou Kuangguo , Cheng Ling , Chen Xing , Wang Jue , Wang Xiao-Min , Zhang Yingchi , Yu Qilin , Zhang Shu , Wang Di , Huang Liang , Huang Mei , Ma Ding , Cheng Tao , Wang Cong-Yi , Yuan Weiping , Zhou Jianfeng 
Published: January 2018

Abstract
Aberrant DNA methylation patterns in leukemia might be exploited for therapeutic targeting. In this study, we employed a genetically deficient mouse model to explore the role of the methylated DNA binding protein MBD2 in normal and malignant hematopoiesis. MBD2 ablation led to diminished lymphocytes. Functional defects of the lymphoid compartment were also observed after in vivo reconstitution of MBD2-deficient hematopoietic stem cells (HSC). In an established model of Notch1-driven T-cell acute lymphoblastic leukemia (T-ALL), MBD2 ablation impeded malignant progression and maintenance by attenuating the Wnt signaling pathway. In clinical specimens of human T-ALL, Wnt signaling pathway signatures were significantly enhanced and positively correlated with the expression and function of MBD2. Furthermore, a number of typical Wnt signaling inhibitory genes were abnormally hypermethylated in primary human T-ALL. Abnormal activation of Wnt signaling in T-ALL was switched off by MBD2 deletion, partially by reactivating epigenetically silenced Wnt signaling inhibitors. Taken together, our results define essential roles for MBD2 in lymphopoiesis and T-ALL and suggest MBD2 as a candidate therapeutic target in T-ALL.
Significance: This study highlights a methylated DNA binding protein as a candidate therapeutic target to improve the treatment of T-cell acute lymphoblastic leukemias, as a new starting point for developing epigenetic therapy in this and other lymphoid malignancies. Cancer Res; 78(7); 1632–42. ©2018 AACR.
High-Risk TP53 Mutations Are Associated with Extranodal Extension in Oral Cavity Squamous Cell Carcinoma
Authors: Sandulache Vlad C. , Michikawa Chieko , Kataria Pranav , Gleber-Netto Frederico O. , Bell Diana , Trivedi Sanchit , Rao Xiayu , Wang Jing , Zhao Mei , Jasser Samar , Myers Jeffrey N. , Pickering Curtis R. 
Published: January 2018

Abstract
Purpose: Development of extranodal extension (ENE) has been associated with poor survival in patients with oral cavity squamous cell carcinoma (OSCC). Here, we sought to confirm the role of ENE as a poor prognostic factor, and identify genomic and epigenetic markers of ENE in order to develop a predictive model and improve treatment selection.
Experimental Design: An institutional cohort (The University of Texas MD Anderson Cancer Center) was utilized to confirm the impact of ENE on clinical outcomes and evaluate the genomic signature of primary and ENE containing tissue. OSCC data from The Cancer Genome Atlas (TCGA) were analyzed for the presence of molecular events associated with nodal and ENE status.
Results: ENE was associated with decreased overall and disease-free survival. Mutation of the TP53 gene was the most common event in ENE+ OSCC. The frequency of TP53 mutation in ENE+ tumors was higher compared with ENE− tumors and wild-type (WT) TP53 was highly represented in pN0 tumors. pN+ENE+ patients had the highest proportion of high-risk TP53 mutations. Both primary tumors (PT) and lymph nodes with ENE (LN) exhibited a high rate of TP53 mutations (58.8% and 58.8%, respectively) with no significant change in allele frequency between the two tissue sites.
Conclusions: ENE is one of the most significant markers of OSCC OS and DFS. There is a shift toward a more aggressive biological phenotype associated with high-risk mutations of the TP53 gene. Prospective clinical trials are required to determine whether TP53 mutational status can be used for personalized treatment decisions. Clin Cancer Res; 24(7); 1727–33. ©2018 AACR.
Higher Thrombin-Antithrombin III Complex Levels May Indicate Severe Acute Pancreatitis
Authors: Fidan Sami , Erkut Murat , Cosar Arif Mansur , Yogun Yasar , Örem Asım , Sönmez Mehmet  , Arslan Mehmet  
Published: January 2018

<b><i>Aim:</i></b> Coagulation disorders may develop in association with severe acute pancreatitis (AP). Plasma thrombin-antithrombin III complex (TAT) levels are one of the principal markers of coagulation disorder. The purpose of this study was to evaluate TAT and other hemostatic parameters in patients with AP and to examine whether or not these parameters indicate the severity of AP. <b><i>Method:</i></b> Forty-six patients with AP (14 severe, 32 non-severe) and a 30-member healthy control group were recruited. The severity of AP was determined using the revised Atlanta classification. ELISA was used to measure patients’ plasma TAT levels. <b><i>Results:</i></b> The TAT levels of AP patients at presentation were higher than those of the control group (<i>p</i> = 0.005). The plasma TAT levels of patients with severe AP were also significantly higher than those of patients with non-severe AP (<i>p</i> = 0.05) and of the control group (<i>p</i> &#x3c; 0.001). The general accuracy, sensitivity and specificity of TAT levels in predicting the severity of AP were 77.4, 77.8, and 77.3% respectively. <b><i>Conclusion:</i></b> The coagulation cascade was activated in the AP patients in our study, and this was shown to become more pronounced as severity of the disease increased. Plasma TAT levels at the time of presentation in patients with AP can be used as a marker for predicting the severity of the disease.
Return to Work and Participation in Society After Out-of-Hospital Cardiac Arrest
Authors: Lilja Gisela , Nielsen Niklas , Bro-Jeppesen John , Dunford Hannah , Friberg Hans , Hofgren Caisa , Horn Janneke , Insorsi Angelo , Kjaergaard Jesper , Nilsson Fredrik , Pelosi Paolo , Winters Tineke , Wise Matt P. , Cronberg Tobias 
Published: January 2018

Background:
The aim of this study was to describe out-of-hospital cardiac arrest (OHCA) survivors’ ability to participate in activities of everyday life and society, including return to work. The specific aim was to evaluate potential effects of cognitive impairment.

Methods and Results:

Two hundred eighty-seven OHCA survivors included in the TTM trial (Target Temperature Management) and 119 matched control patients with ST-segment–elevation myocardial infarction participated in a follow-up 180 days post-event that included assessments of participation, return to work, emotional problems, and cognitive impairment. On the Mayo-Portland Adaptability Inventory-4 Participation Index, OHCA survivors (n=270) reported more restricted participation In everyday life and in society (47% versus 30%;
P
<0.001) compared with ST-segment–elevation myocardial infarction controls (n=118). Furthermore, 27% (n=36) of pre-event working OHCA survivors (n=135) compared with 7% (n=3) of pre-event working ST-segment–elevation myocardial infarction controls (n=45) were on sick leave (odds ratio, 4.9; 95% confidence interval, 1.4–16.8;
P
=0.01). Among the OHCA survivors assumed to return to work (n=135), those with cognitive impairment (n=55) were 3× more likely (odds ratio, 3.3; 95% confidence interval, 1.2–9.3;
P
=0.02) to be on sick leave compared with those without cognitive impairment (n=40; 36%, n=20, versus 15%, n=6). For OHCA survivors, the variables that were found most predictive for a lower participation were depression, restricted mobility, memory impairment, novel problem-solving difficulties, fatigue, and slower processing speed.

Conclusions:
OHCA survivors reported a more restricted societal participation 6 months post-arrest, and their return to work was lower compared with ST-segment–elevation myocardial infarction controls. Cognitive impairment was significantly associated with lower participation, together with the closely related symptoms of fatigue, depression, and restricted mobility. These predictive variables may be used during follow-up to identify OHCA survivors at risk of a less successful recovery that may benefit from further support and rehabilitation.

Clinical Trial Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT01946932.
MicroRNA-195 Regulates Metabolism in Failing Myocardium Via Alterations in Sirtuin 3 Expression and Mitochondrial Protein Acetylation
Authors: Zhang Xiaokan , Ji Ruiping , Liao Xianghai , Castillero Estibaliz , Kennel Peter J. , Brunjes Danielle L. , Franz Marcus , Möbius-Winkler Sven , Drosatos Konstantinos , George Isaac , Chen Emily I. , Colombo Paolo. C. , Schulze P. Christian 
Published: January 2018

Background:
Heart failure leads to mitochondrial dysfunction and metabolic abnormalities of the failing myocardium coupled with an energy-depleted state and cardiac remodeling. The mitochondrial deacetylase sirtuin 3 (SIRT3) plays a pivotal role in the maintenance of mitochondrial function through regulating the mitochondrial acetylome. It is interesting to note that unique cardiac and systemic microRNAs have been shown to play an important role in cardiac remodeling by modulating key signaling elements in the myocardium.

Methods:

Cellular signaling was analyzed in human cardiomyocyte-like AC16 cells, and acetylation levels in rodent models of SIRT3
–/–
and transgenic microRNA-195 (miR-195) overexpression were compared with wild type. Luciferase assays, Western blotting, immunoprecipitation assays, and echocardiographic analysis were performed. Enzymatic activities of pyruvate dehydrogenase (PDH) and ATP synthase were measured.

Results:

In failing human myocardium, we observed induction of miR-195 along with decreased expression of the mitochondrial deacetylase SIRT3 that was associated with increased global protein acetylation. We further investigated the role of miR-195 in SIRT3-mediated metabolic processes and its impact on regulating enzymes involved in deacetylation. Proteomic analysis of the total acetylome showed increased overall acetylation, and specific lysine acetylation of 2 central mitochondrial metabolic enzymes, PDH and ATP synthase, as well. miR-195 downregulates SIRT3 expression through direct 3′-untranslated region targeting. Treatments with either sirtuin inhibitor nicotinamide, small interfering RNA–mediated SIRT3 knockdown or miR-195 overexpression enhanced acetylation of PDH complex and ATP synthase. This effect diminished PDH and ATP synthase activity and impaired mitochondrial respiration.SIRT3
–/–
and miR-195 transgenic mice consistently showed enhanced global protein acetylation, including PDH complex and ATP synthase, associated with decreased enzymatic activity.

Conclusions:
Altogether, these data suggest that increased levels of miR-195 in failing myocardium regulate a novel pathway that involves direct SIRT3 suppression and enzymatic inhibition via increased acetylation of PDH and ATP synthase that are essential for cardiac energy metabolism.
How Reliable Is the Market for Technology?
Authors: Palermo Vincenzo , Higgins Matthew J. , Ceccagnoli Marco 
Published: January 2018

Abstract
Research has focused on why and when firms access external technology markets. Less is known about the reliability of patents attached to licensed technologies during litigation. Unreliable patents expose a firm to loss of downstream revenues. We address this by constructing a data set of patent litigation in the pharmaceutical industry and exploit a change in patent law that exogenously increased the probability of litigation. We find that licensed patents are more likely to fall during litigation. This effect is isolated to firms with fewer intellectual property capabilities and less patenting experience, suggesting that benefits from external technology are not shared equally.
What We Have Time for: Historical Responsibility on the Largest Scale
Authors: Smith Steven G. 
Published: January 2018

Abstract
A historically responsible agent is willing to be somehow in practical solidarity with all other actors with whom action is shared over time. The responsible idea of a most-inclusive history encompasses future occurrence together with all that has happened already. Despite our lack of control over future developments, we assess possible future ages as bright (if action opportunities are generally greater) or dark (if lesser) and position ourselves as contributors to multigenerational endeavors (such as Burke’s “all science” and “all art”) that we hope will be long-term successes in themselves and part of a larger historical optimality. Informed by the evolutionary sciences, a plausible modern envisioning of the future must include evolutionary innovations and surprises on a very long time scale. The historically responsible agent will therefore take seriously efforts like Olaf Stapledon’s Last and First Men to imagine the new powers and goals of our distantly posthuman future sharers in history.
Treatment of Chronic Hepatitis B with Lamivudine in Renal Transplant Recipients
Authors: Zubkin M. , Balakirev E. , Chervinko V. , Baranova F. , Zolotarevsky V. , Bakulin I. , Stahanova V. , Stanke A. , Stenina I. , Kovalchuk A. , Novozhenov V. 
Published: January 2018

Treatment of chronic hepatitis B in renal transplant recipients remains one of the major problems in clinical nephrology. Lamivudine is considered to be a drug of choice for these patients, however, its efficacy in patients with hepatitis B after renal transplantation (RT) has not been completely proven. Twenty-two RT recipients treated with lamivudine were evaluated. The duration of treatment was 15.6±1.9 months. Fourteen patients (64%) had normalization of aminotransferase (ALT); in 9 of them (41% of the whole group), serum HBV DNA was eliminated. Serum HBeAg was undetectable in 4 out of 15 (27%) previously positive patients. It has been statistically proven that the efficacy of lamivudine therapy correlates with degree of fibrosis and higher histological activity index values. We could not establish any correlation between the outcome of antiviral therapy and patients' age, sex, conditions of contagion (while on dialysis or after RT), time lapsed after the infection had been detected, duration of post-transplant period, type of immunosuppression, HBeAg positivity or negativity, ALT levels, concomitant HCV infection. The efficacy of antiviral HBV therapy is limited by the duration of lamivudine treatment: in 4 out of 5 patients with virologic response, the viremia condition relapsed several weeks after the medication had been stopped. Two patients continued to sustain their biochemical response and 1 patient had ALT levels elevated to above normal, but the value was almost twice as low as initially reported. Liver biopsy was repeated in 4 RT recipients after the end of antiviral therapy; in 3 of them positive morphologic changes were observed.
Implant Retention in Infected Joint Replacements: A Surgeon's Perspective
Authors: Theis J.C. 
Published: January 2018

There is no standard treatment for infected joint replacements. The surgical options are varied and treatment choices may pose problems in relation to both efficacy and cost effectiveness. Surgical debridement combined with antibiotic therapy is an appealing option for surgeons and patients as it can lead to eradication of the infection with implant retention and good functional outcome. It avoids major revision surgery which can result in significant morbidity and mortality in an elderly group of patients. The author reviewed 73 patients with hip and knee periprosthetic infections and the data was analyzed in terms of outcome of primary treatment and final outcome, including bacteriology and prosthesis retention. Out of the 73 patients (53 hips and 20 knees), the majority (69%) were managed by primary surgical debridement followed by antibiotics and about one third (34%) lost their implants as a result of the infection. Retention of implants was higher in acute infections (85–100%) as opposed to late infections (20–50%). The microbiological analysis showed that Staphylococcus and Streptococcus caused the majority (76%) of infections. In this series, patients with an infected joint replacement had roughly the same probability (30%) of retaining the original prosthesis, undergoing a successful revision, or having no implants in situ at the end of treatment. (Int J Artif Organs 2008; 31: 804–9)
Development and Evaluation of a Novel Artificial Catheter-Deliverable Prosthetic Heart Valve and Method for in Vitro Testing
Authors: Claiborne Thomase , Bluestein Danny , Schoephoerster Richard T. 
Published: January 2018

Background This work presents a novel artificial prosthetic heart valve designed to be catheter or percutaneously deliverable, and a method for in vitro testing of the device. The device is intended to create superior characteristics in comparison to tissue-based percutaneous valves. Methods The percutaneous heart valve (PHV) was constructed from state-of-the-art polymers, metals and fabrics. It was tested hydrodynamically using a modified left heart simulator (LHS) and statically using a tensile testing device. Results The PHV exhibited a mean transvalvular pressure gradient of less than 15 mmHg and a mean regurgitant fraction of less than 5 percent. It also demonstrated a resistance to migration of up to 6 N and a resistance to crushing of up to 25 N at a diameter of 19 mm. The PHV was crimpable to less than 24 F and was delivered into the operating LHS via a 24 F catheter. Conclusion An artificial PHV was designed and optimized, and an in vitro methodology was developed for testing the valve. The artificial PHV compared favorably to existing tissue-based PHVs. The in vitro test methods proved to be reliable and reproducible. The PHV design proved the feasibility of an artificial alternative to tissue based PHVs, which in their traditional open-heart implantable form are known to have limited in vivo durability.
Detrimental effect of systemic vascular risk factors on brain hemodynamic function assessed with MRI
Authors: King Kevin S , Sheng Min , Liu Peiying , Maroules Christopher D , Rubin Craig D , Peshock Ron M , McColl Roderick W , Lu Hanzhang 
Published: January 2018

Background and purpose Vascular risk factors have been associated with decreased cerebral blood flow (CBF) but this is etiologically nonspecific and may result from vascular insufficiency or a response to decreased brain metabolic activity. We apply new MRI techniques to measure oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen consumption (CMRO2), hypothesizing that decreased CBF related to these vascular risk factors will be associated with increased OEF, confirming a primary vascular insufficiency. Methods 3T MRI was obtained on 70 community-based participants in this IRB-approved study with informed consent, with previous assessment of systolic blood pressure, hypertension medication, elevated serum triglycerides, low serum HDL, and diabetes mellitus. CBF was measured using phase contrast adjusted for brain volume (ml/100 g/min), OEF (%) was obtained from T2-Relaxation-Under-Spin-Tagging (TRUST), and CMRO2 (μmol/100 g/min) was derived using the Fick principle. Stepwise linear regression identified optimal predictors of CBF with age, sex, and hematocrit included for adjustment. This predictive model was then evaluated against OEF and CMRO2. Results Hypertriglyceridemia was associated with low CBF and high OEF. High systolic blood pressure was associated with high CBF and low OEF, which was primarily attributable to those with pressures above 160 mmHg. Neither risk factor was associated with significant differences in cerebral metabolic rate. Conclusion Low CBF related to hypertriglyceridemia was accompanied by high OEF with no significant difference in CMRO2, confirming subclinical vascular insufficiency. High CBF related to high systolic blood pressure likely reflected limitations of autoregulation at higher blood pressures.
Sella turcica bridging and ossified carotico-clinoid ligament: Correlation with sex and age
Authors: Gibelli Daniele , Cellina Michaela , Gibelli Stefano , Panzeri Marta , Oliva Antonio Giancarlo , Termine Giovanni , Sforza Chiarella 
Published: January 2018

Aim Sella turcica bridging and ossified carotico-clinoid ligament are two variants of the sella turcica, the origin of which is partially unknown. These variations should be properly recognised, as they may hamper the removal of the anterior clinoid process in surgical procedures. Therefore, our aim was to determine the prevalence of these two anatomical variants and to investigate their prevalence according to patient sex and age in a series of maxilla computed tomography scans. Materials and methods We revised 300 computed tomography scans of the head from northern Italian patients, stratified into three age groups (18–40 years, 41–60 years, >60 years): a logistic regression analysis was used to explore an association of sella turcica bridging with age and sex through Matlab software, also including a test for the extracted model ( P < 0.05). Results The mean prevalence of sella turcica bridging and ossified carotico-clinoid ligament were 0.16 ± 0.06 (48/300, 16.0%) and 0.09 ± 0.03 (26/300, 8.7%), respectively. Statistically significant differences according to sex were found neither for sella turcica bridging ( P = 0.345) nor for ossified carotico-clinoid ligament ( P = 0.412). Only sella turcica bridging showed a correlation with age ( P = 0.007). In addition, the two variants were often associated, as patients without sella turcica bridging usually did not show ossified carotico-clinoid ligament ( P < 0.001). Discussion Our results suggest an association between the two variants, and provide a novel contribution to the debate around their origin.