bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Qingjin Huatan decoction on pulmonary function and inflammatory mediators in acute exacerbations of chronic obstructive pulmonary disease: a systematic review and meta-analysis
Authors: Du Xuqin , Chen Yong , Zhang Ruodai , Shi Lipeng , Ren Yi 
Published: October 2024

BackgroundThe inflammatory response is the main pathophysiological basis of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) and is a key factor leading to frequent exacerbations and disease progression. Suppressing the inflammatory response can improve pulmonary function, prognosis, and quality of life in AECOPD patients.PurposeTo evaluate the effect of Qingjin Huatan decoction (QHD) on pulmonary function and inflammatory mediators in AECOPD patients.MethodsRandomized controlled trials (RCTs) on the treatment of AECOPD with QHD were retrieved from eight Chinese and English electronic databases up to 31 May 2024. The quality of the studies was assessed using the Cochrane Risk of Bias Tool and the modified Jadad scale. Statistical analysis, sensitivity analysis, and publication bias assessment were performed using Stata 17.0 software.ResultsA total of 40 RCTs involving 3,475 AECOPD patients were included. Compared to conventional treatment, QHD significantly improved pulmonary function, with increases in FEV1 (MD = 0.30, 95% CI: 0.26 to 0.34, p = 0.000), FVC (MD = 0.34, 95% CI: 0.27 to 0.41, p = 0.000), FEV1/FVC (MD = 6.07, 95% CI: 5.55 to 6.58, p = 0.000), and PaO2 (MD = 7.20, 95% CI: 4.94 to 9.47, p = 0.000), and a decrease in PaCO2 (MD = −5.37, 95% CI: 7.99 to −2.74, p = 0.000). QHD also significantly suppressed the expression of inflammatory mediators, including TNF-α (MD = −10.87, 95% CI: 12.51 to −9.23, p = 0.000), IL-1β (MD = −13.63, 95% CI: −16.31 to −10.95, p = 0.000), IL-6 (MD = −7.58, 95% CI: −10.10 to −5.06, p = 0.000), IL-8 (MD = −9.45, 95% CI: −12.05 to −6.85, p = 0.000), CRP (MD = −5.62, 95% CI: −6.60 to −4.65, p = 0.000), and PCT (MD = −0.84, 95% CI: −1.07 to −0.62, p = 0.000). Additionally, QHD improved clinical efficacy (RR = 4.16, 95% CI: 3.26 to 5.30, p = 0.000) without increasing the incidence of adverse reactions (RR = 1.04, 95% CI: 0.68 to 1.61, p = 0.000).ConclusionExisting evidence suggests that QHD can significantly improve pulmonary function, suppress the expression of inflammatory mediators, and enhance clinical efficacy in AECOPD patients, with a good safety profile. Given the limitations of this study, more high-quality studies are needed to provide reliable evidence.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=559436, identifier CRD42024559436
A cross-sectional study of factors associated with carotid atherosclerosis
Authors: Dai Guokui , Cai Xiangsheng , Ye Chuanjiang , Zhang Yuzhen , Guan Ruoping 
Published: October 2024

ObjectiveThe aim of this work was to study the relationship between carotid atherosclerosis (CAS) and several indexes and provide a basis for the prevention and treatment of cardiovascular and cerebrovascular diseases.MethodsThere were 11,028 adults who underwent physical examination at the Guangzhou Cadre and Talent Health Management Center from January 2023 to December 2023 and were selected as research subjects. Retrospective analysis was used to understand the carotid atherosclerosis of the examined population and analyze its relationship with sex, age, blood pressure, blood glucose, blood lipids, renal function, 25-hydroxyvitamin D, neutrophil to lymphocyte count ratio (NLR), platelet to lymphocyte count ratio (PLR), systemic immune inflammation index (SII), monocyte count to high-density lipoprotein cholesterol ratio (MHR), triglyceride glucose body mass index (TyG-BMI), insulin resistance metabolic index (METS-IR), and other indicators.ResultsAmong 11,028 subjects, the detection rate of carotid atherosclerotic thickening (CAT) was 12.00% and carotid atherosclerotic plaque (CAP) was 25.11%. The CAT and CAP detection rates in men were 13.32% and 28.78%, respectively, which were higher than the CAT detection rate of 8.28% and CAP detection rate of 14.80% in women, and the differences were statistically significant (both p &lt; 0.001). Multivariate logistic regression analysis using TyG-BMI and METS-IR as two indicators was modeled separately, and the results showed that CAS was associated with men, increasing age, and systolic blood pressure. The area under the curve (AUC) was analyzed using the subject’s work characteristic (ROC) curve in the descending order of METS-IR, TyG-BMI, and MHR. The combination of the three indexes of sex, age, and METS-IR predicted atherosclerosis with the highest AUC values.ConclusionCarotid atherosclerosis is highly prevalent in men. Elevation of systolic blood pressure, fasting glucose, MHR, and TyG-BMI (or METS-IR) with age are independent influences on carotid atherosclerosis. The three indexes of MHR, TyG-BMI, and METS-IR, respectively, in combination with sex and age, can be used as a new and effective index to predict CAS.
Developing a specific model to exploring the determinant of individuals’ attitude toward forest conservation
Authors: Maleknia Rahim , Azizi Reza , Hălălișan Aureliu Florin 
Published: October 2024

IntroductionIn the context of forest conservation, individuals’ attitude can significantly influence their intentions and subsequent behaviors towards conserving forests. However, there is a research gap when it comes to understanding the determinants of individuals’ attitude towards forests conservation. To address this gap, the present study aimed to investigate the influence of variables associated with values from value-belief-norm theory, awareness of consequences, and ascription of responsibility from norm activation model on individuals’ attitudes as main determinant of behavior intention.MethodsThe Data of study was collected from a sample of 200 students from Behbahan University, Iran. through a questionnaire designed specifically for this purpose. The validity and reliability of questionnaire were confirmed. Structural equation modeling was employed to analyze the collected data.ResultsThe findings of the study revealed that the examined variables were able to describe 88.6% of the variance in individuals’ attitude towards forest conservation. Specifically, it was found that biospheric (ƛ= 0.097) and altruistic (ƛ= 0.385) values, ascription of responsibility (ƛ= 0.150), and awareness of consequences (ƛ= 0.380) had significant and positive effects on individuals’ attitude towards forest conservation. On the other hand, egoistic values exhibited a significant and negative impact (ƛ= –0.071) on individuals’ attitude.DiscussionThese research findings hold significant implications for planners and policymakers involved in forest conservation efforts. By understanding the factors that shape individuals’ conservation attitudes, decision-makers can develop targeted strategies and interventions to strengthen positive attitudes towards forest conservation. Given the positive influence of biospheric values and awareness of consequences, developing awareness-raising programs to enhance individuals’ environmental knowledge and the awareness of outcomes of their conservation actions can be considered as strategy to strengthen public’s attitude and improvement their participation in forest conservation projects.
Systematic analysis and prediction of the burden of lower respiratory tract infections attribute to non-optimal temperature, 1990–2019
Authors: Shi Yu , Zhang Liping , Wu Di , Yilihamu Yilipa , Wang Lei 
Published: October 2024

BackgroundLower respiratory infections (LRIs) remain one of the most deadly infectious diseases in the world, and non-optimal temperature is a risk factor for LRIs. The aim of this study was to analyze the global burden of LRI attribute to non-optimal temperature and its trends from 1990 to 2019, and to project long-term trends.MethodsExcerpts from the release of the 2019 Global Burden of Disease (GBD) study, which analyses the burden of lower respiratory infections due to non-optimal temperatures from 1990 to 2019 using data on deaths and disability adjusted life years (DALYs); explores differences across regions, populations and seasons, and projects future trends in burden.ResultsBetween 1990 and 2019, there is a significant downward trend in the global burden of deaths and DALYs, but it remains high in infants and young children, the older adult, African countries and LOW SDI regions. Differences in geographical risk factors and economic levels lead to heterogeneous disease burdens across regions. In 2019, low SDI regions will have the highest burden, but high SDI regions will have the highest number of deaths. In addition, increasing SDI values were associated with decreasing trends in age-standardized mortality rates and disability-adjusted life years. BAPC model projections suggest a downward trend in the future burden of death and DALYs from the disease, but the improvement in the burden of death for women was not significant.ConclusionOur study comprehensively elucidates the distribution and dynamic trends in the burden of lower respiratory tract infections due to non-optimal temperatures from 1990 to 2019 along multiple dimensions. The burden of deaths and DALYs showed an overall decreasing trend, but the improvement was uneven in different regions. In addition, the results suggest that efforts should be made to reduce lower respiratory health losses in infants, young children, and older adult populations. Effective public health policies and interventions to reduce the burden of lower respiratory tract infections should be sustained globally.
Kyasanur Forest Disease: An Epidemiological Investigation and Case-Control Study in Shivamogga, Karnataka, India-2022
Authors: Vedachalam Srividya K. , Rajput Bhavesh L. , Choudhary Sushma , Narayanaswamy Darshan , Chandra Sharath , D. M. Pallavi , Rajagopal Padma M. , Dikid Tanzin 
Published: October 2024

ObjectiveKyasanur Forest Disease (KFD) is a viral zoonosis reported from Karnataka, India. We investigated cases in the Shivamogga district, Karnataka, to describe the epidemiology and identify risk factors in the affected block in 2022.MethodsA case was defined as a laboratory-confirmed KFD-positive resident of Shivamogga from 1 January-31 May 2022. We extracted the records of KFD cases from district surveillance. We conducted a 1:3 case-control study in the Thirthahalli block. We enrolled laboratory-confirmed KFD-positive Thirthahalli residents from January to May 2022 as cases, and residents without “fever with myalgia” as controls. We reported adjusted odds ratios (aOR) with 95% confidence intervals (CI).ResultsShivamogga reported 35 cases, with a median age of 46 (4–75) years, of which 51% were men, and one death. Among 25 cases and 90 controls, knowledge of avoiding recent monkey death sites was low (cases = 0%, controls = 11%). Monkey death sites within 500 m [aOR = 8.6 (1.8–41.9)] and household tick exposure [aOR = 3.7 (1.3–10.7)] were independent risk factors.ConclusionThis was a laboratory-confirmed cluster of KFD cases in Thirthahalli, with residence near a monkey death site and household tick exposure considered significant risk factors. We recommend evaluating monkey carcass disposal procedures and increasing awareness of tick protective measures.
Оценка возможности использования части стока реки Салгир для обеспечения водной безопасности Крыма
Authors: Герасимов М.М. , Свердликов А.А. , Беляк А.А. , Смирнов А.Д. , Николенко И.В. , Сафонов А.Н. , Копачевский А.М. 
Published: October 2024

Разработан, смонтирован и введен в эксплуатацию пилотный комплекс для испытаний технологий очистки воды реки Салгир. Представлены результаты испытаний как проектной технологической схемы водоочистных сооружений Межгорного гидроузла Республики Крым, так и нескольких предлагаемых модернизированных схем, включающих применение сорбентов и окислителей, на пилотном испытательном комплексе на реальной воде водоисточника. Обеспечить необходимую эффективность очистки воды по перманганатной окисляемости и нормированные значения бихроматной окисляемости удалось в технологической схеме при двукратном дозировании порошкообразного активного угля в сочетании с окислителем – перекисью водорода. Подтверждена возможность использования реки Салгир как источника водоснабжения населения Республики Крым.
A pilot complex for testing technologies for the purification of the Salgir River water has been developed, assembled and commissioned. The test results are presented for both the design process flow scheme of the water treatment facilities of the Mezhgornyi Hydroengineering Complex of the Republic of Crimea and a number of proposed upgraded flow schemes involving the use of sorbents and oxidizers at the pilot complex with real water from the water source. Meeting the required degree of water purification efficiency for the permanganate index and rated values of dichromate oxidizability was achieved with the process flow scheme with double dosing of powdered activated carbon in combination with an oxidizer – hydrogen peroxide. The feasibility of using the Salgir River as a water source for supplying water to the population of the Republic of Crimea has been confirmed.
Pengaruh Transparansi Penanganan Perkara dan Kepercayaan Terhadap Loyalitas melalui Kepuasan Klien pada Kantor Hukum Puspita Sukardi dan Partner
Authors: Sukardi Sukardi , Rosanti Novita , Sujatmiko Sujatmiko 
Published: October 2024

Tujuan penelitian ini adalah untuk mengetahui dan menganalisis Pengaruh Transparansi Penanganan Perkara Dan Kepercayaan Terhadap Loyalitas Melalui Kepuasan Klien Pada Kantor Hukum Puspita Sukardi Dan Partner secara langsung maupun tidak langsung. Adapun metode analisis yang digunakan adalah Path Analysis dengan tujuan untuk menggambarkan keadaan objek penelitian yang sesungguhnya untuk mengetahui Pengaruh Transparansi Penanganan Perkara Dan Kepercayaan Terhadap Loyalitas Melalui Kepuasan Klien Pada Kantor Hukum Puspita Sukardi Dan Partner melalui pengajuan pernyataan di dalam kuesioner kepada klien. Hasil penelitian yang diperoleh adalah (1)Transparansi Penanganan Perkara berpengaruh Positif dan Signifikan terhadap Kepuasan Klien Pada Kantor Hukum Puspitas Sukardi dan Partner, (2) Kepercayaan berpengaruh Positif Tidak Signifikan terhadap Kepuasan Klien Pada Kantor Hukum Puspitas Sukardi dan Partner (3) Kepuasan Klien berpengaruh Positif dan Signifikan terhadap Loyalitas Pada Kantor Hukum Puspitas Sukardi dan Partner.(4) Transparansi Penangan Perkara berpengaruh Positif dan Signifikan terhadap Loyalitas Pada Kantor Hukum Puspitas Sukardi dan Partner, (5) Kepercayaan berpengaruh Positif dan Signifikan terhadap Loyalitas Pada Kantor Hukum Puspitas Sukardi dan Partner, (6) Transparansi Penangan Perkara berpengaruh Positif dan Signifikan terhadap Loyalitas Melalui Kepuasan Klien Pada Kantor Hukum Puspitas Sukardi dan Partner, dan (7) Kepercayaan berpengaruh tidak Signifikan terhadap Loyalitas Melalui Kepuasan Klien Pada Kantor Hukum Puspitas Sukardi dan Partner.
PERFIL EPIDEMIOLÓGICO DE MORTALIDADE MATERNA NO BRASIL NA ÚLTIMA DÉCADA
Authors: Martins Francisca de Assis Fernandes , Abdalla Neto José , Carvalho Raelma Almeida de , Mendes Camila Vitória Ferreira , Carvalho Timóteo Graf , Fonseca Giulia Pereira da , Cunha Noelia Priscilla de Oliveira , Portela Nytale Lindsay Cardoso , Macedo Antônio Eduardo Resplandes , Lima Eutiene Dos Santos , Rocha Bruno Martins , Gonçalves Jasley Siqueira , Silva Sernandes Rodrigues da , Lopes Gustavo Sales de Oliveira 
Published: October 2024

Objetivo: Caracterizar o perfil epidemiológico e sociodemográfico da mortalidade materna no Brasil na última década (20100 a 2019). Método: Trata-se de uma pesquisa epidemiológica descritiva, exploratória e transversal, com abordagem quantitativa, realizada entre os anos de 2010 a 2019. A coleta de dados foi realizada através de dados secundários, tendo como fontes: O Sistema de Informação sobre Mortalidade (SIM), aba: óbitos em mulheres em idade fértil no Brasil. As variáveis analisadas: região, tipos de causas obstétricas, categoria CID-10, ano do óbito, faixa etária, cor/raça, escolaridade, estado civil, local de ocorrência, óbitos maternos. As informações coletadas foram tabuladas no software Excel. Resultados: Entre 2010 e 2019 foram notificados 16.697 (100,0%) óbitos maternos no Brasil, sendo a região Sudeste com o maior número de casos (35,6%), seguida da região Nordeste (33,5%). Houve maior incidência entre mulheres de 20 a 29 anos (39,4%), da cor parda, na região Nordeste (67,1 %), com 8 a 11 anos de estudo (30,0%); quanto ao estado civil a maioria das mulheres eram solteiras (49,2%). Sobre as causas obstétricas, 69,2% morreram por causa obstétrica direta, sendo de acordo com a categoria CID-10, as principais causas foram: eclampsia (14,2%), hemorragia pós-parto (9,1%) e hipertensão gestacional com proteinúria significante (10,1%). Conclusão: A mortalidade materna continua sendo um problema de saúde pública no Brasil e esse fato é um indicador de como está a atenção à saúde da mulher no período gravídico puerperal.
Top-down feedback normalizes distortion in early visual word recognition: Insights from masked priming
Authors: Fernández-López Maria , Solaja Olga , Crepaldi Davide , Perea Manuel 
Published: October 2024

AbstractThe identification of visually presented words tolerates distortions in the input format, as Hannagan et al. Plos One, 7, e32121, (2012) demonstrated in a masked priming lexical decision task, showing sizable identity-priming effects with CAPTCHA-like primes. This tolerance to distortion has two potential explanations: bottom-up normalization in the encoding stage (Dehaene et al., Trends in Cognitive Sciences, 9, 335–341, 2005) or top-down lexical feedback (McClelland & Rumelhart, Psychological Review, 88, 375–407, 1981). To disentangle the predictions of these accounts, we conducted two masked identity-priming experiments with printed and CAPTCHA-like distorted primes on high- and low-frequency words. The rationale was that, in the distorted format, high-frequency words would benefit more from top-down feedback than low-frequency words. Results in the lexical decision experiment showed that, for high-frequency words, identity-priming effects were only slightly greater for printed than for CAPTCHA-like primes, whereas this difference was larger for low-frequency words. In contrast, when employing the same-different matching task, which does not require lexical access, the identity-priming effect was greater for printed primes and was unaffected by word frequency. Thus, during lexical access, top-down feedback may help normalize the visual input in the early stages of word recognition, challenging bottom-up models of visual word recognition.
Alignment of digital health value propositions to business models in sub-Saharan Africa
Authors: Ogundaini Oluwamayowa O. , Achieng Mourine S. 
Published: October 2024

Orientation: Digital health delivers value in the form of efficiency, efficacy and transformation by automation and strengthening of global health care systems, according to the World Health Organization. Yet, sub-Saharan Africa’s (SSA) health care systems still experience an evident misalignment between their business models (BMs) and digital health value propositions. As a result, digital health interventions (DHI) are duplicated for similar purposes; several pilot projects hardly reach country-wide implementation and health security remains unattainable, in the Fourth Industrial Revolution era.Research purpose: The study aims to conduct a scoping review highlighting how the value-add propositions of DHI could align with health care system BMs in SSA.Motivation for the study: The study was informed by the need to address the impact of health care business models on adopting Digital Health and advanced Industry 4.0 technologies for Health Security in the sub-Saharan Africa (SSA) context.Research design, approach and method: The paper followed Arksey and O’Malley’s five-stage scoping review guide to identify publications on the value propositions of DHI in health care systems of SSA.Main findings: There is limited scholarly work focused on how sub-Saharan African health care system BMs cater to DHI in relation to the fast-paced advancements in technology. Drivers of value-add creation, inhibitors of digital health value capture and the requirements of BMs that support the value propositions offered by DHI were discussed.Practical/managerial implications: Findings can assist health managers to redirect the trajectory of integrating digital health value propositions interventions in SSA health care systems towards redressing recurrent challenges that inhibit technology adoption.Contribution/value-add: The paper highlights how the value-add propositions of digital health should be aligned to BMs of health care systems in SSA to ensure duplications are addressed and provide a move towards wide-scale implementations.
Potential liquid biopsy markers of exosomal microRNAs in renal interstitial fibrosis blood and urine
Authors: Lv Chunyan , Zhong Yuan , Hu Yao , Tang Yan 
Published: October 2024

ABSTRACT

Objective:
To explore more and better liquid biopsy markers of exosomal microRNAs (exo-miRNAs) in renal interstitial fibrosis (RIF) and to preliminary investigate the biological functions and signaling pathways involved in these markers.

MATERIALS AND METHODS:
High-throughput miRNA sequencing was performed on blood and urine exo-miRNAs from three RIF patients and three healthy volunteers, and differential expression analysis and bioinformatic processing were performed.

Results:
There were 13 differentially expressed exo-miRNA (DEexo-miRNA) between RIF and healthy blood, and 20 DEexo-miRNAs in urine. These were various DEexo-miRNAs in different specimens, and the former included PC-3p-213532_58, hsa-miR-338-5p_R-1, PC-5p-34127_410, pal-miR-9993a-3p_L+2R-1, and hsa-miR-26a-1-3p with intermediate expression levels; the latter involved hsa-miR-126-3p, hsa-miR-217-5p, hsa-miR-199b-3p_R-1, mmu-miR-5106_R-4_1ss1AG, and PC-5p-39041_356, and others, while hsa-miR-378a-3p, hsa-miR-143-3p_R+1, hsa-miR-183-5p, hsa-miR-126-3p, hsa-miR-155-5p_R-1, mmu-miR-5106_R-4_1ss1AG, hsa-miR-126-5p, and hsa-miR-199b-3p_R-1 had high expression levels. Bioinformatics analysis of the up-regulated DEmiRNA with high expression in urine showed that there are 291 target corresponding mRNAs for six of eight DEexo-miRNAs, with mmu-miR-5106_R-4_1ss1AG and hsa-miR-199b-3p_R-1 having no target gene found in TargetScan and miRanda. GO annotation revealed that GO:0005515 (protein binding) had the lowest P value, involving the most genes. KEGG analysis revealed that the signaling included the mTOR signaling pathway, autophagy - animal, etc., and hsa05200 (pathways in cancer) had a lower P value, involving the most genes.

Conclusions:
Urine is a better sample for RIF exo-miRNA detection than blood. Urinary exosomal hsa-miR-143-3p_R+1, hsa-miR-183-5p, hsa-miR-126-3p, mmu-miR-5106_R-4_1ss1AG, hsa-miR-126-5p, and hsa-miR-199b-3p_R-1 are novel liquid biopsy markers for RIF. These DEexo-miRNA may be associated with the occurrence and development of RIF and may participate in specific biological processes by regulating the expression of their target mRNA. Further research may require exploring the specific functions and mechanisms of these miRNAs in RIF, as well as whether they can serve as diagnostic or therapeutic targets for RIF.