bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semi-Automatic Analysis for Unidimensional Immunoblot Images to Discriminate Breast Cancer Cases Using Time Series Data Mining
Authors: Sánchez-Silva Diana M. , Acosta-Mesa Héctor G. , Romo-González Tania 
Published: May 2017

Breast cancer (BC) is one of the leading causes of death in adult women worldwide and the best way to reduce mortality and improve prognosis is through early diagnosis. Thus, it is necessary to optimize diagnostic methods; one option could be the automatic detection of patterns in 1D-II. In that respect, through recent analysis of unidimensional Immunoblot Images (1D-II), it was possible to distinguish between women with and without breast disease using as a discrimination criterion the presence of autoantibodies (bands) in their blood. However, the analysis of 1D-II is a difficult task even for an expert, generating great subjectivity and complexity in the process of interpretation. In the present study, a semi-automatic methodology for the bands’ analysis contained in the 1D-II’s was implemented and evaluated, the bands were extracted using digital image processing techniques. This was possible through the recognition of banding patterns represented as time series to distinguish between three classes: women with breast cancer (BC), women with benign breast pathology (BBP) and women without breast pathology (H). The classification was performed using the machine learning algorithm k-nearest neighbors (KNN) with different parameters over the time series representation. The semi-automatic method here presented was able to reduce the time, complexity and subjectivity of the image analysis with the performance metrics compared, obtaining similar percentages for both representations. With the traditional analysis, binary representation [Accuracy 72.8%, Precision 73.42% for three classes (BC, BBP and H) and Accuracy 90.91% Accuracy 92.55% Sensitivity 93.57% and Specificity 92.99% for two classes (BC and H)], versus Time series representation [Accuracy 66.4%, Precision 67.07% for three classes (BC, BBP and H) and Accuracy 86.36% Accuracy 87.31% Sensitivity 95.86% and Specificity 85.56% for two classes (BC and H)].
Three Types of Asymmetry in the Muscovite Engagement with Print
Authors: Franklin Simon 
Published: May 2017

Muscovite awareness and use of printed books both predated and extended beyond the scope of native Muscovite printing. The three types of “asymmetry” explored in this survey relate to the wider reception of print in Muscovy. The first and most widely noted is the chronological and cultural mismatch between the spread of print culture in Russia and in Western Europe. The second is the differential chronology and repertoire of local print production by comparison with the use of imported printed materials. The third – the main focus of the survey – is the phenomenon of “reverse technology transfer,” whereby West European printed materials were appropriated into manuscript culture in Muscovy. Examples are adduced from diverse and unrelated fields: medical knowledge, newspapers, and biblical illustration. Taken together, these patterns of asymmetry not only pose a challenge to “techno-determinist” approaches to the history of writing and print, but reflect a distinctive ecology of media, a distinctive set of cultural filters in the translation of print to Muscovy.
Social stigma, legal and public health barriers faced by the third gender phenomena in Brazil, India and Mexico: Travestis, hijras and muxes
Authors: Diehl Alessandra , Vieira Denise Leite , Zaneti Marina Milograna , Fanganiello Ana , Sharan Pratap , Robles Rebecca , de Jesus Mari Jair 
Published: May 2017

Aim and Methods: The aim of this article is to provide a narrative literature review of the ‘third gender’ phenomenon in Brazil ( Travestis), India ( Hijras) and Mexico ( Muxes), considering the social stigma, the legal and health aspects of these identities. Results: These three groups share similar experiences of stigmatisation, marginalisation, sexual abuse, HIV infection, infringement of civil rights and harassment accessing health services. Brazil, India and Mexico public services for the third gender conditions are still very scarce and inadequate for the heavy demand from potential users. Discussion and Conclusion: Although all three countries have used legislation to promote provision of comprehensive healthcare services for third gender, there is still strong resistance to implementation of such laws and policies. Brazil, India and Mexico face a huge challenge to become countries where all human rights are respected.
Intravenous dexmedetomidine during spinal anaesthesia for caesarean section: A meta-analysis of randomized trials
Authors: Bao Zeqing , Zhou Chengmao , Wang Xianxue , Zhu Yu 
Published: May 2017

Objective To evaluate the efficacy and safety of spinal anaesthesia using dexmedetomidine for caesarean section. Methods PubMed, The Cochrane Library, and CNKI were searched for relevant literature. Results The incidence of nausea and vomiting in the dexmedetomidine group was significantly lower than that in the control group (OR = 0.21, 95% CI: 0.12–0.35, P < 0.00001). No difference was found in the incidence of pruritus between the two groups (OR = 1.21, 95% CI: 0.36–4.09, P = 0.76).The dexmedetomidine group had a higher incidence of bradycardia than did the control group (OR = 2.20, 95% CI: 1.02–4.77, P = 0.05). The incidence of shivering in the dexmedetomidine group was significantly lower than that in the control group (OR = 0.20, 95% CI: 0.13–0.32, P < 0.00001). The incidence of hypotension was not different between the two groups (OR = 0.88, 95% CI: 0.49–1.56, P = 0.65). Conclusion Dexmedetomidine can decrease the incidence of nausea, vomiting, bradycardia, and shivering with spinal anaesthesia during caesarean section.
Evaluation of serum neutrophil gelatinase-associated lipocalin in predicting acute kidney injury in critically ill patients
Authors: Hang Chen-Chen , yang Jun , Wang Shuo , Li Chun-Sheng , Tang Zi-Ren 
Published: May 2017

Objective This investigation evaluated the real-time point-of-care testing (RT-POCT) of neutrophil gelatinase-associated lipocalin (NGAL) for detecting acute kidney injury (AKI) and prognosis of critically ill patients. Methods A total of 249 critically ill patients in the emergency department (ED), who were diagnosed with acute decompensated heart failure, sepsis or diabetic ketoacidosis were enrolled in this study. All enrolled patients were followed up for 28 days or to death and the mortalities were recorded. Serum creatinine (sCr) and NGAL were measured. Results 40.6% enrolled patients deteriorated to AKI during the observation period. The NGAL level was significantly higher in the AKI versus non-AKI group. The NGAL levels in the non-survivors group at 7-day and 28-day were significantly higher than in the survivors group. NGAL was detected as an independent risk factor of AKI, and 7-day and 28-day morality. The receiver operating characteristic curve of NGAL was calculated for diagnosing AKI; the area under the curve (AUC) was significantly higher than that of 1-day eGFR. Conclusions NGAL is an independent predictor of AKI, and 7-day and 28-day mortality in critically ill ED patients, and can be an early alert for AKI and useful for determining prognosis.
Political Identity and Economists’ Perceptions of Capitalist Crises
Authors: Horowitz Mark , Hughes Robert 
Published: May 2017

Radical critics have long impugned conventional economists as ideologically committed to capitalism and blind to its historical dynamics and crisis tendencies. This report evaluates this longstanding criticism. Surveying academic economists in the United States, we find the field quite skeptical of the prospects of capitalist crises. Despite considerable consensus, political orientation is a highly significant predictor of respondents’ outlooks. We close by interpreting our findings from the standpoint of current research in political psychology. Jel classification: A13, A14, B14
Observation of a Pharmacist-Conducted Group A Streptococcal Pharyngitis Point-of-Care Test: A Time and Motion Study
Authors: Corn Carolyn E. , Klepser Donald G. , Dering-Anderson Allison M. , Brown Terrence G. , Klepser Michael E. , Smith Jaclyn K. 
Published: May 2017

Background: Acute pharyngitis is among the most common infectious diseases encountered in the United States, resulting in 13 million patient visits annually, with group A streptococcus (GAS) being a common causative pathogen. It is estimated that annual expenditures for the treatment of adult pharyngitis will exceed US$1.2 billion annually. This substantial projection reinforces the need to evaluate diagnosis and treatment of adult pharyngitis in nontraditional settings. Objective: The objective of this research is to quantify the amount of pharmacist time required to complete a point-of-care (POC) test for a patient presenting with pharyngitis symptoms. Methods: A standardized patient with pharyngitis symptoms visited 11 pharmacies for POC testing services for a total of 33 patient encounters. An observer was present at each encounter and recorded the total encounter time, divided into 9 categories. Pharmacists conducted POC testing in 1 of 2 ways: sequence 1—pharmacists performed all service-related tasks; sequence 2—both pharmacists and pharmacist interns performed service-related tasks. Results: The average time for completion of a POC test for GAS pharyngitis was 25.3 ± 4.8 minutes. The average pharmacist participation time per encounter was 12.7 ± 3.0 minutes (sequence 1), which decreased to 2.6 ± 1.1 minutes when pharmacist interns were involved in the testing (sequence 2). Conclusion: Although additional studies are required to further assess service feasibility, this study indicates that a GAS POC testing service could be implemented in a community pharmacy with limited disruption or change to workflow and staff.
Health Disparities in Women
Authors: Hornbuckle Lyndsey M , Amutah-Onukagha Ndidiamaka , Bryan Alicia , Skidmore Edwards Elizabeth , Madzima Takudzwa , Massey Kelly , May Linda , Robinson Leah E 
Published: May 2017

Aims and scope: Clinical Medicine Insights: Women’s Health is an international, open-access, peer-reviewed journal which considers manuscripts on all aspects of the diagnosis, management, and prevention of disorders specific to women, in addition to related genetic, pathophysiological, and epidemiological topics. Clinical Medicine Insights: Women’s Health aims to provide researchers working in this complex, quickly developing field with online, open access to highly relevant scholarly articles by leading international researchers. In a field where the literature is ever-expanding, researchers increasingly need access to up-to-date, high-quality scholarly articles on areas of specific contemporary interest. This supplement is on Health Disparities in Women. This supplement aims to address this by presenting high-quality articles that allow readers to distinguish the signal from the noise. The editor in chief hopes that through this effort, practitioners and researchers will be aided in finding answers to some of the most complex and pressing issues of our time.
Bridging the Research-Practice Divide Through the Intermediary Model
Authors: Gunasekaran Senthil , Krishnadevarajan Pradip , Barry Lawrence F. 
Published: May 2017

The Problem The gap between research and practice has been recognized and analyzed across multiple fields. Various solutions have been proposed but the gap persists. Although there are consistent calls for joint actions through collaborations between scholars and practitioners, not many in either party have taken it as their primary responsibilities. Thus, incremental or suboptimal efforts have been made to bridge the great divide. The Solution In this article, we propose forming a new entity—intermediary—as an effective approach to transforming research into practice. Also, we share a real-world case to illustrate how this approach and its outcome can contribute to closing the research-practice divide. The Stakeholders Three stakeholders will benefit from this research—scholars, practitioners, and intermediaries. Both scholars and practitioners will better understand the transformation process and various ways to close research-practice divide. Intermediaries will have a better knowledge about how their contributions, skills and motivations are different from other two stakeholders.
Cardiac rehabilitation in patients with ST-segment elevation myocardial infarction: can its failure be predicted?
Authors: Irzmański Robert , Kapusta Joanna , Obrębska-Stefaniak Agnieszka , Urzędowicz Beata , Kowalski Jan 
Published: May 2017

Background: The prognosis in patients after acute coronary syndromes (ACS) is significantly burdened by coexisting anaemia, leukocytosis and low glomerular filtration rate (GFR). Hyperglycaemia in the early stages of ACS is a strong predictor of death and heart failure in non-diabetic subjects. This study aimed to evaluate the effect of hyperglycaemia, anaemia, leukocytosis, thrombocytopaenia and decreased GFR on the risk of the failure of cardiac rehabilitation (phase II at the hospital) in post-ST-segment elevation myocardial infarction (STEMI) patients. Methods: The study included 136 post-STEMI patients, 96 men and 40 women, aged 60.1 ± 11.8 years, admitted for cardiac rehabilitation (phase II) to the Department of Internal Medicine and Cardiac Rehabilitation, WAM University Hospital in Lodz, Poland. On admission fasting blood cell count was performed and serum glucose and creatinine level was determined (GFR assessment). The following results were considered abnormal: glucose ⩾ 100 mg/dl, GFR < 60 ml/min/1, 73 m², red blood cells (RBCs) < 4 × 106/μl, white blood cells (WBCs) > 10 × 103/μl; platelets (PLTs) < 150 × 10³/ml. In all patients an exercise test was performed twice, before and after the completion of the second stage of rehabilitation, to assess its effects. Results: Based on logistic regression analysis and the results of an individual odds ratio (OR) of the tested parameters, their prognostic impact was determined on the risk of failure of cardiac rehabilitation. This risk has been defined on the basis of the patient’s inability to tolerate workload increment >5 Watt in spite of the applied program of cardiac rehabilitation. As a result of building a logistic regression model, the most statistically significant risk factors were selected, on the basis of which cardiac rehabilitation failure index was determined. leukocytosis and reduced GFR determined most significantly the risk of failure of cardiac rehabilitation (respectively OR = 6.42 and OR = 3.29, p = 0.007). These parameters were subsequently utilized to construct a rehabilitation failure index. Conclusions: Peripheral blood cell count and GFR are important in assessing the prognosis of cardiac rehabilitation effects. leukocytosis and decreased GFR determine to the highest degree the risk of cardiac rehabilitation failure. Cardiac rehabilitation failure index may be useful in classifying patients into an appropriate model of rehabilitation. These findings support our earlier reports.
Glomerular Filtration Rate Trends During Follow-up in Children With Steroid-Sensitive Nephrotic Syndrome
Authors: Alsaidi Sulaiman , Wagner Daniel , Grisaru Silviu , Midgley Julian , Hamiwka Lorraine , Wade Andrew , Nettel-Aguirre Alberto , Samuel Susan 
Published: May 2017

Background: Overall prognosis of children with steroid-sensitive nephrotic syndrome (SSNS) is regarded as generally favorable. However, only a few recent studies have evaluated changes in kidney function and blood pressure over time in children with SSNS. Objectives: We describe clinical features of SSNS patients and characterize changes in calculated estimated glomerular filtration rate (eGFR) and use of antihypertensive medications during follow-up. Design: This is a retrospective cohort study. Setting: This study was conducted in a Canadian pediatric nephrology center. Patients: This study included patients aged 1 to 18 years with SSNS. Measurements: eGFR was calculated from recorded serum creatinine and height measurements using the modified Schwartz equation. Methods: eGFR was calculated at yearly intervals, and the trend of eGFR was assessed using linear mixed effects model. Patients were also evaluated for use of antihypertensive medications during follow-up. Results: Seventy-eight patients—median age, 3.2 years (interquartile range [IQR], 2.65) and median follow-up of 4.37 (IQR, 5.6)—were evaluated. Sixty-three (80.8%) had at least 1 relapse. Twenty-two (28.2%) and 20 (25.6%) were steroid dependent and frequently relapsing, respectively. Forty-three patients (55.1%) received at least 1 steroid-sparing agent, and of these, 18 (41.8%) received a calcineurin inhibitor. One patient had eGFR ≤90 mL/min/1.73 m2 during observation. eGFR remained unchanged over the follow-up period in this cohort of patients. Four patients (5.1%) were on antihypertensive medications at the end of follow-up. Limitations: Patients who had frequent relapses had more measurements available for serum creatinine and height, creating a sampling bias. The number of eGFR measurements was overall small, making it difficult to ascertain eGFR trend. Conclusion: eGFR remained unchanged over time in this cohort, and a small proportion of patients required antihypertensive therapy at the end of follow-up. Our study highlights the needs for carefully constructed long-term observational studies of children with nephrotic syndrome.
Effects of expiratory muscle strength training on maximal respiratory pressure and swallow-related quality of life in individuals with multiple sclerosis
Authors: Silverman Erin Pearson , Miller Sarah , Zhang Yi , Hoffman-Ruddy Bari , Yeager James , Daly Janis J 
Published: May 2017

Background Weakening and dyscoordination of expiratory muscles in multiple sclerosis (MS) can impair respiratory and swallow function. Objective The objective of this paper is to test a novel expiratory muscle strength training (EMST) device on expiratory pressure, swallow function, and swallow-related quality-of-life (SWAL-QOL) in individuals with MS. Methods Participants with MS were randomized to a five-week breathing practice of either positive pressure load (EMST) or near-zero pressure (sham). We compared baseline to post-treatment data according to maximum expiratory pressure (MEP), abnormal airway penetration and aspiration (PAS), and SWAL-QOL. Results Both groups improved in MEP ( p < 0.001). Forty percent of the EMST group improved on PAS, and 15% worsened; conversely, 21.4% of the sham group worsened and 14.3% improved. There was no group difference in overall SWAL-QOL; but the EMST group had significantly greater gain versus sham on the Burden ( p = 0.014) and Pharyngeal Swallow ( p = 0.022) domains. Both groups improved in SWAL-QOL domains of Fear, Burden Mental Health, but only the EMST group improved in the SWAL-QOL and domains of Pharyngeal Swallow function, and Saliva management. Conclusion Results suggest that strengthening of expiratory muscles can occur with repetition of focused breathing practice in the absence of high resistance. Conversely, results from the PAS and SWAL-QOL domains suggest that the high resistance of the EMST was required in order to improve the functional safety (reduced penetration/aspiration) and coordination of swallowing, specifically pharyngeal function and saliva management.
TGF-β1 -509C/T polymorphism and susceptibility to keloid disease: a systematic review and meta-analysis
Authors: Tu Yiji , Lineaweaver William Charles , Zhang Feng 
Published: May 2017

Background: Keloid disease (KD) is common and often refractory to treatment. Definition of the genetic mechanisms of KD can lead to a better understanding of the disease and suggest more effective treatment strategies. Objectives: To quantitatively estimate the association between KD susceptibility and the -509C/T polymorphism in the TGF-β1 gene. Methods: PubMed, Embase and CNKI databases were searched using a combination of the Medical Subject Headings (MeSH) and relevant words in titles. Analyses were performed with STATA 12.0. Results: Five case-control studies encompassing a total of 564 keloid cases and 620 healthy controls were pooled in the final meta-analysis. Among the five studies, no significant association was detected between the TGF-β1 -509C/T polymorphism and KD under all of the five genetic models (allele comparison, heterozygote comparison, homozygote comparison, dominant model and recessive model) for the overall analyses and for the subgroup analyses based on DNA extraction method, participant ethnicity and group size. When stratified by study quality, three high-quality studies showed significant association under allele comparison and homozygote model (C versus T: OR = 0.80, 95% confidence interval [CI] = 0.65–0.98, P = 0.03; I2 = 0%, P = 0.64; CC versus TT: OR = 0.62, 95% CI = 0.41–0.94, P = 0.02; I2 = 0%, P = 0.79); while two moderate-quality studies showed significant association under allele comparison, homozygote model and recessive model (C versus T: OR = 1.52, 95% CI = 1.15–2.01, P = 0.004; I2 = 39%, P = 0.20; CC versus TT: OR = 2.14, 95% CI = 1.24–3.70, P = 0.02; I2 = 19%, P = 0.27; CC versus CT+TT: OR = 2.04, 95% CI = 1.29–3.24, P = 0.002; I2 = 0%, P = 0.35). Conclusions: The current meta-analysis suggests that the TGF-β1 -509C/T polymorphism is not associated with KD susceptibility. High-quality and large-scale studies are needed to validate our findings.
Response to Antenatal Cholecalciferol Supplementation Is Associated With Common Vitamin D–Related Genetic Variants
Authors: Moon Rebecca J , Harvey Nicholas C , Cooper Cyrus , D’Angelo Stefania , Curtis Elizabeth M , Crozier Sarah R , Barton Sheila J , Robinson Sian M , Godfrey Keith M , Graham Nikki J , Holloway John W , Bishop Nicholas J , Kennedy Stephen , Papageorghiou Aris T , Schoenmakers Inez , Fraser Robert , Gandhi Saurabh V , Prentice Ann , Inskip Hazel M , Javaid M Kassim ,   the Maternal Vitamin D Osteoporosis Study Trial Group
Published: May 2017

Abstract

Context
Single-nucleotide polymorphisms (SNPs) in genes related to vitamin D metabolism have been associated with serum 25-hydroxyvitamin D [25(OH)D] concentration, but these relationships have not been examined following antenatal cholecalciferol supplementation.

Objective
To determine whether SNPs in DHCR7, CYP2R1, CYP24A1, and GC are associated with the response to gestational cholecalciferol supplementation.

Design
Within-randomization group analysis of the Maternal Vitamin D Osteoporosis Study trial of antenatal cholecalciferol supplementation.

Setting
Hospital antenatal clinics.

Participants
In total, 682 women of white ethnicity (351 placebo, 331 cholecalciferol) were included. SNPs at rs12785878 (DHCR7), rs10741657 (CYP2R1), rs6013897 (CYP24A1), and rs2282679 (GC) were genotyped.

Interventions
1000 IU/d cholecalciferol from 14 weeks of gestation until delivery.

Main Outcome Measure
25(OH)D at randomization and 34 weeks of gestation were measured in a single batch (Liaison; Diasorin, Dartford, UK). Associations between 25(OH)D and the SNPs were assessed by linear regression using an additive model [β represents the change in 25(OH)D per additional common allele].

Results
Only rs12785878 (DHCR7) was associated with baseline 25(OH)D [β = 3.1 nmol/L; 95% confidence interval (CI), 1.0 to 5.2 nmol/L; P &lt; 0.004]. In contrast, rs10741657 (CYP2R1) (β = −5.2 nmol/L; 95% CI, −8.2 to −2.2 nmol/L; P = 0.001) and rs2282679 (GC) (β = 4.2 nmol/L; 95% CI, 0.9 to 7.5 nmol/L; P = 0.01) were associated with achieved 25(OH)D status following supplementation, whereas rs12785878 and rs6013897 (CYP24A1) were not.

Conclusions
Genetic variation in DHCR7, which encodes 7-dehyrocholesterol reductase in the epidermal vitamin D biosynthesis pathway, appears to modify baseline 25(OH)D. In contrast, the response to antenatal cholecalciferol supplementation was associated with SNPs in CYP2R1, which may alter 25-hydroxylase activity, and GC, which may affect vitamin D binding protein synthesis or metabolite affinity.