bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phase II Study of Palbociclib in Patients with Tumors with CDK4 or CDK6 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1C
Authors: O’Hara Mark H. , Jegede Opeyemi , Dickson Mark A. , DeMichele Angela M. , Piekarz Richard , Gray Robert J. , Wang Victoria , McShane Lisa M. , Rubinstein Lawrence V. , Patton David R. , Williams P. Mickey , Hamilton Stanley R. , Onitilo Adedayo , Tricoli James V. , Conley Barbara A. , Arteaga Carlos L. , Harris Lyndsay N. , O’Dwyer Peter J. , Chen Alice P. , Flaherty Keith T. 
Published: October 2024

Abstract

Purpose:
Amplification of cyclin-dependent kinase 4 (CDK4) and CDK6 is a feature of a variety of malignancies, and preclinical evidence suggests that inhibition of CDK4/6 is a plausible treatment strategy in these tumors. Subprotocol Z1C of the NCI-Molecular Analysis for Therapy Choice trial was designed to evaluate the CDK4/6 inhibitor palbociclib in CDK4- or CDK6-amplified tumors.

Patients and Methods:
Patients had a solid malignancy or lymphoma with progression on at least one systemic therapy for advanced disease or with no standard-of-care therapy available. Tumors with ≥7 copies of CDK4 or CDK6 were considered amplified and molecularly eligible. Enrolled patients were treated with palbociclib 125 mg daily on days 1 to 21 of a 28-day cycle. The primary endpoint was objective response rate.

Results:
Forty-three patients were enrolled on subprotocol Z1C, and 38 patients were deemed eligible, treated, and included in analyses; 25 patients were eligible, treated, and centrally confirmed to have CDK4 or CDK6 amplification and comprised the primary analysis cohort for objective response rate endpoint. Among the 25 patients in the primary cohort, one patient had a partial response, 4 patients had stable disease, and 16 patients had progressive disease as best response. Four patients were not evaluable due to lack of follow-up scans. Among the 38 evaluable patients, one patient had a partial response, 10 patients had stable disease, and 21 patients had progressive disease as best response. Partial response and stable disease were seen only in patients with CDK4 amplification. Median progression-free survival was 2.0 months, and median overall survival was 8.8 months.

Conclusions:
Palbociclib showed limited activity in histology-agnostic CDK4- or CDK6-amplified tumors, although central nervous system tumors may be worthy of future investigation.
Reanimating Hobbes’s Materialism: Afterthoughts on Samantha Frost’s Lessons from a Materialist Thinker
Authors: Robison Meghan 
Published: October 2024

Abstract
This contribution to a symposium on Samantha Frost’s Lessons from a Materialist Thinker considers Frost’s interpretation of Hobbesian Man and the connection between man and the Commonwealth. Particular attention is paid to Frost’s interpretation of man as an interdependent and intersubjective living creature and the relationship between living embodiment and agency. Through this focused examination, this contribution aims to elucidate the critical questions raised by Lessons and identify promising avenues for future Hobbes scholarship by highlighting the key insights that reshape our understanding of his enduring influence on modern political thought.
Constraints on Female Labor Force Participation in Qatar: Understanding the Effects of Marriage, Family, and Traditional Values
Authors: Blaydes Lisa , Gengler Justin , Lari Noora 
Published: October 2024

Abstract
This paper examines constraints to female labor force participation in Qatar, a country where state revenue from natural resource rents means any citizen can secure a public sector job should they seek employment. Using data from an original survey and focus groups, we find that although Qataris are generally in support of female labor force participation – both in principle and for their own relatives – concerns remain about the impact of women working for marriage, family, and traditional values. These concerns may be especially salient for younger Qatari men – a constituency particularly impacted by erosion of traditional gender norms at a time when they are establishing their own households. We also find that Qataris with a larger percentage of male children tend to be less supportive of women working outside of the home, suggesting forms of family-level variation in investment in patriarchal values and child rearing practices.
Crafting Cross-Border Connections: Religion and Perceptions of Erdoğan in the Middle East and North Africa
Authors: Ciftci Sabri 
Published: October 2024

Abstract
This study examines how religion influences public opinion about foreign leaders, focusing on attitudes toward Turkish President Recep Tayyip Erdoğan, a pivotal figure in mena. Through the lens of image theory and Arab public opinion research, it offers fresh perspectives on the complex interaction between religion, understood as a multidimensional concept, and public sentiment. The empirical analysis of Gallup and Arab Barometer surveys reveals meaningful effects of piety, sectarianism, and Islamist ideology on perceptions of Erdoğan. Particularly, Erdoğan’s portrayal as a devout Sunni leader and a staunch Islamist strongly resonates among ordinary Arab citizens. While opposition to normalization with Israel engender support for Erdoğan, anti-Americanism does not exert a meaningful effect relative to religious considerations. This study underscores the role of the secular-Islamist divide, piety, and sectarianism in shaping perceptions of foreign leaders, calling for further scholarly inquiry into the nexus of religion, international politics, and public opinion in mena.
Astral Sciences among the Safavids: Bahāʾ al-Dīn al-ʿĀmilī on the Prayer Niche Direction (qibla) and the Crescent Garden
Authors: Mahdavi Younes 
Published: October 2024

Abstract
The dispute between science and religion evolved into diverse forms in the early modern period. Among the advocates of science, not all manifested anti-religious sentiments, and in some instances, religious authorities even supported scientific methods in resolving secular and sacred problems. Sixteenth-century Persia, under the Safavid monarchy, witnessed disputes between proponents and opponents of scientific methods in addressing religious and civic matters. In this article, I will present two polemics between scholars and jurists who served the Safavid shahs concerning the relevance of astral sciences in resolving religious matters. The first dispute concerns determining the orientation of the prayer niche direction (qibla). The second concerns legalizing the practice of astral sciences in general. For the matter of the prayer niche, I will discuss a dispute that occurred at the court of Ṭahmāsb I (r. 1524–76) between ʿAlī ibn Ḥusayn al-Karakī (d. 1534), the first chief jurisconsult (shaykh al-islām) at the Safavid court, and Ghiyāth al-Dīn Manṣūr Dashtakī (1461–1542), which proved to be a failure for science and a success for tradition. For the case of the astral sciences, I will examine two attempts by Bahāʾ al-Dīn al-ʿĀmilī (1547–1621), the successor to al-Karakī at the court of ʿAbbās I (r. 1587–1629), to justify the permissibility of scientific methods in addressing matters of jurisprudence. I will discuss ʿĀmilī’s opinion on the prayer niche in four of his works, and will introduce and examine his Crescent Garden (al-Ḥadīqa al-hilāliyya), a commentary on a prayer for crescent sighting. I will further show that although the first attempt failed to establish scientific credibility for astronomy and astrology at the court, the second proved successful both in the royal and civic realms.
The Iroquois Confederacy and the Possibility of Heteronomous Democracy
Authors: Karavitis Gerasimos 
Published: October 2024

Abstract
Cornelius Castoriadis (1922–1997) argues that the project of autonomy appears in only two societies throughout human history: ancient Greece and Western Europe. Is this true? The present study examines the case of the Iroquois Confederacy with the intention of testing Castoriadis’s argument. Using the debate between Castoriadis and the members of mauss as its starting point, it interprets historic Iroquois institutions with reference to what Castoriadis presents as the two inextricably linked conditions of an autonomous society: democracy and philosophy. Ultimately, the essay contends that while Castoriadis justifiably interprets the Iroquois Confederacy as heteronomous, the confederacy’s democratic institutions compel us to doubt the necessary connection he posits between democracy and philosophy. Iroquois society created a heteronomous democracy, a type of polity that Castoriadis’s theory of autonomy occludes.
Differential Degradation of Wooden Cutting Boards and Ergonomic Aspects of Beef and Chevon Marketing in Port Harcourt, Nigeria
Authors: Adedeji Gabriel Adetoye , Aiyeloja Adedapo Ayo , Egubogo Azuka Chinedum , Amaogu Daniel Chukwuemeka , Adeyeye Oluwatosin Adetutu , Imoeko Remilekun Joy 
Published: October 2024

Abstract
Although wood degradation and ergonomics are critical design issues in the wood product industry worldwide, data on wood as a degradable and culturally important material for cutting meat and the ergonomics of meat marketing in urban Nigerian markets are unavailable. This study investigated the degradation of wooden cutting boards (WCB) caused by meat cutting and marketing ergonomics. Degradation was estimated using eight WCB administered to four participants marketing chevon and four participants marketing beef. Descriptive and anthropometric data were obtained from 129 participants using questionnaires and measurements. The degradation results showed that after three months, cutting meat caused a significant monthly average WCB loss of 19.6 ± 4% and 11.6 ± 4% and a cumulative weight loss of 58.17% and 34.72% for chevon and beef, respectively. A substantial number of meat marketers were found to work in awkward postures, especially in the upper extremity mismatched condition, where they potentially exert more force, resulting in contact between the cutting tools and WCB that degrades the cutting board during meat cutting. Therefore, mismatched working conditions are a feasible and heightened factor contributing to wood degradation during meat cutting and marketing. The results can help people gain a deeper understanding of wood degradation from commercial meat cutting and the ergonomics of meat marketing and provide strategies for ensuring a sustainable supply of high-quality wood and improving ergonomic conditions.
The Prospective Application of Machine Learning in Turbulence Forecasting over China
Authors: Shao Jingyuan , Zhuang Zibo , Yu Zhenyu , Lin Kunyun , Wu Kaijun , Leung Yan Yu , Chan Pak Wai 
Published: October 2024

Abstract
This study analyzes the spatiotemporal distribution of turbulence in China from 2020 to 2022 using pilot reports. Results reveal a higher frequency of moderate-to-severe turbulence during spring and winter, particularly in January. Spatially, the primary regions of turbulence occurrence are eastern China, Xinjiang Province, Sichuan Province, and the Qiongzhou Strait, with a focus on altitudes at or above 6000 m. Machine learning models, especially random forest and extreme gradient boosting (XGBoost), demonstrate high accuracy in turbulence prediction, notably for high-altitude events. The random forest model shows optimal performance in winter, achieving an area under the curve of 0.92. The study highlights the importance of thermally related diagnostics, indicating a significant presence of convectively induced turbulence in high-altitude turbulence events. This research not only deepens the understanding of turbulence dynamics in the China region but also underscores the potential of machine learning in enhancing turbulence forecasting.
Theoretical analysis of water-droplet condensation and evaporation in prescribed environment with radiation
Authors: Brewster M. Q. 
Published: October 2024

Abstract
A quasi-explicit algebraic solution of the problem of quasi-steady water droplet heat- and mass-transfer with condensation or evaporation in a prescribed environment including radiation has been obtained. The solution is based on the mass-fraction form of Fick’s law of species diffusive mass transport, which allows accounting for variation in gas density through the diffusion layer surrounding the droplet. A new term, the average vapor supersaturation through the diffusion layer, has been included that allows the model to be extended to environmental conditions significantly outside those for which it is theoretically derived (dilute or near-saturation), even to conditions of relatively high temperature, low relative humidity, and low pressure. The latter two have atmospheric significance because evaporative cooling can induce significant decrease in droplet temperature and possibly induce freezing. Basic modeling assumptions are confirmed by comparison with time-dependent temperature and evaporation-rate measurements of a laboratory laser-heated droplet. Accuracy of the new model is assessed by comparison with exact equations. For temperatures between −30 and 0°C and negligible radiation, relative-error magnitudes in droplet temperature and evaporation rate are less than 5%, even for relative humidity down to 10% and pressure down to 60 kPa. This represents an improvement in accuracy over the conventional model, in which property variations of density and supersaturation through the diffusion layer are not taken into account. Differences in predicted evaporation rates between the mass-fraction and the more common partial-density Fick’s laws, which can be significant (>10% above 70% relative humidity) in coupled, implicit equations, are shown to be made negligibly small (<0.5%) by linearizing about the saturation state.
Behavioral Correlates of Caregiver-Reported Oral Health of Children with Cleft Palate with or without Cleft Lip Ages 14 to 48 Months: An Observational Study
Authors: Holland Haley , Pollard Sarah Hatch , Chapman Kathy , Chi Donald L. ,   on behalf of the Cleft Outcomes Research NETwork (CORNET) Consortium
Published: October 2024

To identify behaviors associated with poor caregiver-reported oral health in a population of young children with cleft palate with or without cleft lip (CP ± L). Observational cross-sectional study. U.S. Cleft Outcomes Research NETwork (CORNET) Consortium Eight hundred thirty-four caregivers of US children with CP ± L ages 14 to 48 months who provided demographic and medical information and answered 8 items on oral health behaviors (eg, sugar-sweetened beverage intake frequency, having a regular source of dental care, toothbrushing, and fluoride exposure). Caregiver-reported oral health status of the child (poor/fair vs good/very good). Logistic regression models were used to generate confounder-adjusted odds ratios (OR) and evaluate associations between oral health behaviors and caregiver-reported oral health status of the child. The mean age of children was 25.5 ± 7.5 months, 82.7% were white, and 24.1% were Hispanic/Latino. About 16.7% of caregivers reported their child's oral health as fair/poor. Children consuming 2+ servings of juice and/or sugar-sweetened beverages daily (OR: 2.18; 95% confidence interval [CI]: 1.2, 4.0; P = 0.011), those drinking bottled water (OR: 1.75; 95% CI: 1.0, 3.1; P = 0.049), and those consuming 1+ servings of meal replacement drinks daily (OR: 2.86; 95% CI: 1.2, 6.5; P = 0.015) had increased odds of fair/poor caregiver-reported child oral health. Sugar-sweetened beverages and meal replacement drinks, as well as bottled water intake, were associated with poorer caregiver-reported oral health for children with CP ± L. Future research should focus on ways to improve beverage-related behaviors in children with CP ± L to prevent dental diseases and promote oral health.
Zanubrutinib, obinutuzumab, and venetoclax for first-line treatment of mantle cell lymphoma with a TP53 mutation
Authors: Kumar Anita , Soumerai Jacob , Abramson Jeremy S. , Barnes Jeffrey A. , Caron Philip , Chhabra Shalini , Chabowska Maria , Dogan Ahmet , Falchi Lorenzo , Grieve Clare , Haydu J. Erika , Johnson Patrick Connor , Joseph Ashlee , Kelly Hailey E. , Labarre Alyssa , Lue Jennifer Kimberly , Martignetti Rosalba , Mi Joanna , Moskowitz Alison , Owens Colette , Plummer Sean , Puccio Madeline , Salles Gilles , Seshan Venkatraman , Simkins Elizabeth , Slupe Natalie , Zhang Honglei , Zelenetz Andrew D. 
Published: October 2024

Abstract
TP53-mutant mantle cell lymphoma (MCL) is associated with poor survival outcomes with standard chemoimmunotherapy. We conducted a multicenter, phase 2 study of zanubrutinib, obinutuzumab, and venetoclax (BOVen) in untreated patients with MCL with a TP53 mutation. Patients initially received 160 mg zanubrutinib twice daily and obinutuzumab. Obinutuzumab at a dose of 1000 mg was given on cycle 1 day 1, 8, and 15, and on day 1 of cycles 2 to 8. After 2 cycles, venetoclax was added with weekly dose ramp-up to 400 mg daily. After 24 cycles, if patients were in complete remission with undetectable minimal residual disease (uMRD) using an immunosequencing assay, treatment was discontinued. The primary end point was met if ≥11 patients were progression free at 2 years. The study included 25 patients with untreated MCL with a TP53 mutation. The best overall response rate was 96% (24/25) and the complete response rate was 88% (22/25). Frequency of uMRD at a sensitivity level of 1 × 10–5 and uMRD at a sensitivity level of 1 × 10–6 at cycle 13 was 95% (18/19) and 84% (16/19), respectively. With a median follow-up of 28.2 months, the 2-year progression-free, disease-specific, and overall survival were 72%, 91%, and 76%, respectively. Common side effects were generally low grade and included diarrhea (64%), neutropenia (32%), and infusion-related reactions (24%). BOVen was well tolerated and met its primary efficacy end point in TP53-mutant MCL. These data support its use and ongoing evaluation. This trial was registered at www.ClinicalTrials.gov as #NCT03824483.
Whole genome sequence analysis of multi-drug resistant and biofilm-forming Staphylococcus haemolyticus isolated from bovine milk
Authors: Ajose Daniel Jesuwenu , Abolarinwa Tesleem Olatunde , Oluwarinde Bukola Opeyemi , Montso Peter Kotsoana , Fayemi Omolola Esther , Aremu Adeyemi Oladapo , Ateba Collins Njie 
Published: October 2024

Abstract
Background
Milk is an excellent growth medium for microorganisms due to its nutritive composition. Microorganisms have been implicated in bovine mastitis (BM) in dairy cows as well as causing infections in animals and humans. Despite extensive endeavours to manage BM, this condition continues to persist as the most prevalent and economically burdensome problem affecting dairy cattle on a global scale. Non-aureus staphylococci (NAS) species such as Staphylococcus haemolyticus, S. epidermidis, and S. xylosus are currently the predominant microbiological agents identified as the main cause of subclinical udder infections and are also considered opportunistic pathogens in cases of clinical mastitis in dairy cows. Therefore, it is crucial to elucidate the genetic profile of these species. The primary objective of this study was to characterise three phenotypically determined multidrug-resistant NAS environmental strains (NWU MKU1, NWU MKU2, and NWU MKS3) obtained from dairy cows milk via whole-genome sequencing.

Results
The results confirmed that the three isolates were S. haemolyticus with genome sizes of 2.44, 2.56, and 2.56 Mb and a G + C content of 32.8%. The genomes contained an array of antibiotic resistance genes that may potentially confer resistance to a range of antibiotic classes, such as macrolides, fluoroquinolones, aminoglycosides, cephalosporins, tetracyclines, peptides, and phenicol. Furthermore, all the genomes carried virulence genes, which are responsible for several functions, such as adhesion, enzyme and toxin production. The genomes of these organisms contained signatures encoding mobile genetic elements such as prophages and insertion sequences.

Conclusion
These findings indicate there is a need for diligent monitoring with improved management practices and quality control strategies on farms to safeguard milk production systems and human health.
Social connection in long-term care homes: a qualitative study of barriers and facilitators
Authors: Chapman Hannah , Bethell Jennifer , Dewan Neha , Liougas Madalena P. , Livingston Gill , McGilton Katherine S. , Sommerlad Andrew 
Published: October 2024

Abstract
Background
Social connection is a basic human need and is essential to quality of life. It is associated with better mental and physical health outcomes for long-term care (LTC) home residents and is a key aspect of quality of care and person-centred care. There are considerations for LTC homes that may present obstacles to and opportunities for social connection. It is therefore important to understand what restricts or enables good social connection in LTC homes, to guide better quality care and future interventions in this population. This qualitative study aims to identify barriers and facilitators to social connection for LTC residents.

Methods
We used thematic analysis to describe themes derived from individual and group qualitative interviews from 67 participants (18 residents, 17 staff members and clinicians, 32 family members and friends) recruited from LTC homes in the United Kingdom and Canada.

Results
Themes were grouped into four categories: (1) becoming familiar with life in the LTC home to support social connection; (2) physical and virtual access beyond the LTC home as strategies to maintain contact; (3) getting to know residents to deepen relationships; (4) person-centred approaches to build social connection. ‘Becoming familiar with life in the LTC home to support social connection’ described the benefits of counteracting the institutionalized feel of LTC homes, enabling LTC residents to spend time in meaningful ways, and increasing freedom of mobility around the home. ‘Physical and virtual access beyond the LTC home as strategies to maintain contact’ related to the benefits of outings, providing support with technology, and involving family and friends in LTC home life. ‘Getting to know residents to deepen relationships’ related to the benefits of using routine care and interactions as opportunities for social contact, using family and friend knowledge as a resource, and fostering resident relationships. ‘Person-centred approaches to build social connection’ included considering physical, mental, cognitive, and sensory impairments, accounting for adjustment and sociability, using communal spaces well, and prioritizing psychosocial needs.

Conclusions
This study identifies barriers and facilitators to social connection for LTC residents which can be addressed in care policies, staff selection and training, and can inform policies and interventions to build and maintain social connection in LTC homes.

Clinical trial number
clinicaltrials.gov ID NCT05315960.