bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative assessment of the diagnostic efficacy of [18F]AlF-NOTA-FAPI-04 and [18F]FDG PET/CT imaging for detecting postoperative recurrence in gastric cancer patients: a pilot study
Authors: Yang Jian , Wu Yong , Zhang Yanyin , Peng Xiang , Jiang Chengzhi , Zhou Wanjing , Dai Jiashun , Xie Aimin , Ye Hui , Zheng Kai 
Published: September 2024

PurposeThis study aimed to compare the efficacy of [18F]AlF-NOTA-FAPI-04 PET/CT with that of [18F]FDG PET/CT for detecting postoperative recurrence in patients with gastric cancer.MethodsThis single-center retrospective clinical study was performed at Hunan Cancer Hospital between December 2020 and June 2022. The participants underwent both [18F]AlF-NOTA-FAPI-04 and [18F]FDG within 14 days. Histopathologic examination, morphological imaging, and/or follow-up imaging were used as a reference for the final diagnosis. We recorded the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of [18F]AlF-NOTA-FAPI-04 and [18F]FDG PET/CT for detecting local recurrence, lymph node metastasis and distant metastasis. The SUVmax and background ratio (TBR) of local recurrence and metastases between [18F]FDG and [18F]AlF-NOTA-FAPI-04 PET/CT were compared using paired-sample t tests.ResultsForty-seven patients (27 males, aged 25–68 years) with gastric cancer after curative resection (27 with adenocarcinoma, 17 with signet ring cell carcinoma and 4 with mucinous adenocarcinoma) were included in the study. [18F]AlF-NOTA-FAPI-04 accumulation was significantly greater than that of [18F]FDG in terms of local recurrence (SUVmax, 11.65 vs 3.48, p&lt; 0.0001; TBR, 12.93 vs 2.94, p&lt; 0.0001), lymph node metastasis (SUVmax, 13.45 vs 3.05, p=0.003875; TBR, 12.43 vs 2.21, p=0.001661), and distant metastasis (SUVmax, 11.89 vs 2.96, p &lt; 0.0001; TBR, 13.32 vs 2.32, p&lt; 0.0001). Despite no statistical comparison was made with [18F]FDG, [18F]AlF-NOTA-FAPI-04 imaging exhibited high levels of sensitivity, specificity, PPV, NPV, and accuracy for detecting postoperative local recurrence, lymph node metastasis, and distant metastasis in patients with gastric cancer.Conclusion[18F]AlF-NOTA-FAPI-04 has demonstrated potential for more accurate tumor re-evaluation in GC, thus enhancing treatment decision-making.
Development of transcriptomic tools for predicting the response to individual drug of the mFOLFIRINOX regimen in patients with metastatic pancreatic cancer
Authors: Fraunhoffer Nicolas , Teyssedou Carlos , Pessaux Patrick , Bigonnet Martin , Dusetti Nelson , Iovanna Juan 
Published: September 2024

BackgroundThe utilization of modified FOLFIRINOX (mFFX) therapy has shown notable advancements in patient outcomes in both localized and metastatic PDAC. Nevertheless, the effectiveness of mFFX treatment comes at the cost of elevated toxicity, leading to its restriction to patients with adequate performance status. Consequently, the administration of mFFX is contingent upon patient performance rather than rational criteria. The ideal scenario would involve the ability to assess the sensitivity of each drug within the mFFX regimen, minimizing unnecessary toxicity without compromising clinical benefits.MethodsWe developed transcriptomic signatures for each drug of the mFFX regimen (5FU, oxaliplatin and irinotecan) by integrating transcriptomic data from PDC, PDO and PDX with their corresponding chemo-response profiles to capture the biological components responsible for the response to each drug. We further validated the signatures in a cohort of 167 patients with advanced and metastatic PDAC.ResultsAll three signatures captured high responder patients for OS and PFS in the mFFX arm exclusively. We then studied the response of patients to 0, 1, 2 and 3 drugs and we identified a positive correlation between the number of drugs predicted as sensitive and the OS and PFS, and the with objective response rate.ConclusionsWe developed three novel transcriptome-based signatures which define sensitivity for each mFFX components that can be used to rationalize the administration of the mFFX regimen in patients with metastatic pancreatic cancer and could help to avoid unnecessary toxic effects.
DJ-1 regulates mitochondrial function and promotes retinal ganglion cell survival under high glucose-induced oxidative stress
Authors: Peng Hanhan , Li Haoyu , Ma Benteng , Sun Xinyue , Chen Baihua 
Published: September 2024

PurposeThis study aimed to investigate the antioxidative and neuroprotective effects of DJ-1 in mitigating retinal ganglion cell (RGC) damage induced by high glucose (HG).MethodsA diabetic mouse model and an HG-induced R28 cell model were employed for loss- and gain-of-function experiments. The expression levels of apoptosis and oxidative stress-related factors, including Bax, Bcl-2, caspase3, Catalase, MnSOD, GCLC, Cyto c, and GPx-1/2, were assessed in both animal and cell models using Western blotting. Retinal structure and function were evaluated through HE staining, electroretinogram, and RGC counting. Mitochondrial function and apoptosis were determined using JC-1 and TUNEL staining, and reactive oxygen species (ROS) measurement.ResultsIn the mouse model, hyperglycemia resulted in reduced retinal DJ-1 expression, retinal structural and functional damage, disrupted redox protein profiles, and mitochondrial dysfunction. Elevated glucose levels induced mitochondrial impairment, ROS generation, abnormal protein expression, and apoptosis in R28 cells. Augmenting DJ-1 expression demonstrated a restoration of mitochondrial homeostasis and alleviated diabetes-induced morphological and functional impairments both in vivo and in vitro.ConclusionThis study provides novel insights into the regulatory role of DJ-1 in mitochondrial dynamics, suggesting a potential avenue for enhancing RGC survival in diabetic retinopathy.
Immediate changes in stroke patients’ gait following the application of lower extremity elastic strap binding technique
Authors: Liu Yuduo , Wang Qi , Li Qiujie , Cui Xueji , Chen Huimeng , Wan Xianglin 
Published: September 2024

ObjectiveTo ascertain the immediate changes in stroke patients’ temporal and spatial parameters of gait and the joint angles of stroke patients throughout the entire gait cycle following the application of lower extremity elastic strap binding technique.MethodsTwenty-nine stroke patients were invited as the study participants. The patient seated, flexed the hip and knee, utilized a 5 cm-wide elastic strap, positioning its midpoint beneath the affected foot and crossing it anterior to the ankle joint. Upon standing, the strap encircled the posterior aspect of the lower leg, proceeded around the back of the knee, and ascended the thigh on the affected side. Crossing anteriorly over the thigh, it then encircled the back of the waist before being secured in place. Using Qualisys motion capture system to collect kinematic data of the lower extremities during walking while wearing shoes only or strapping. A paired sample t-test was used to analyze the effects of the technique on gait spatiotemporal parameters and joint angles in stroke patients.ResultsThe patients’ step length decreased (P = 0.024), and step width increased (P = 0.008) during the gait cycle after the strapping. In the gait cycle between 0% and 2%, 7%–77%, and 95%–100%, the hip flexion angle on the affected side was significantly larger after the strapping (P &lt; 0.05). In the gait cycle between 0% to 69% and 94%–100%, the knee flexion angle on the affected side was significantly larger after the strapping (P &lt; 0.05). In the gait cycle between 0% to 57% and 67%–100%, the ankle dorsiflexion angle on the affected side was significantly smaller after the strapping (P &lt; 0.05), and in the gait cycle between 0% to 35% and 68%–100%, the ankle inversion angle on the affected side was significantly smaller after the strapping (P &lt; 0.05).ConclusionThe lower extremity elastic strap binding technique can decrease the hip flexion and knee flexion limitations in stroke patients during walking, and reduce the ankle plantar flexion and ankle inversion angle of stroke patients. The lower extremity elastic strap binding technique enabled stroke patients to adopt a more stable gait pattern.
Assessing physical fitness adaptations in collegiate male soccer players through training load parameters: a two-arm randomized study on combined small-sided games and running-based high-intensity interval training
Authors: Quan YanXiu , Zhao YongXing , Musa Rabiu Muazu , Morgans Ryland , Silva Rui Miguel , Hung Chin-Hwai , Chen Yung-Sheng 
Published: September 2024

ObjectiveTo evaluate the effects of a 4-week intervention combining small-sided games (SSGs) and high-intensity interval training (HIIT) on physical fitness in collegiate male soccer players.MethodsTwenty-one soccer players were randomly assigned to either the HIIT + SSGs group (n = 11) or a control group (n = 10). Physical fitness was assessed at baseline and 1-week post-intervention, including countermovement jump (CMJ), change of direction (COD) test, sprint test, repeated sprint ability (RSA) test, and 30–15 Intermittent Fitness Test (30-15IFT). The intervention comprised eight sessions over 4 weeks: four SSGs and four HIIT.ResultsThe intervention group showed small to moderate improvements: mean RSA improved by 4.5% (p = 0.07), CMJ increased by 3.2% (p = 0.12), and 30–15IFT scores enhanced by 6.8% (p = 0.09). Key predictors of group membership included heart rate load per minute (OR 1.602) and various GPS variables.ConclusionThe 4-week intervention combining SSGs with HIIT did not produce statistically significant improvements in most physical fitness variables compared to the control group. Although there were positive trends in variables such as RSA and 30-15IFT, these changes were modest and not statistically significant. The results suggest that while the combined SSGs and HIIT approach shows potential, its impact on physical fitness over a 4-week period is limited, with some variables, like CMJ, even showing decreases.
Music and reading activities in early childhood associated with improved language development in preterm infants at 2–3 years of age
Authors: Kostilainen Kaisamari , Fontell Noora , Mikkola Kaija , Pakarinen Satu , Virtala Paula , Huotilainen Minna , Fellman Vineta , Partanen Eino 
Published: September 2024

IntroductionChildren born preterm are at increased risk for adverse neurodevelopmental outcomes. Music and reading activities in childhood could ameliorate these difficulties, as they have shown benefits on both neural and behavioral levels. However, only a few studies have assessed these potential benefits in preterm-born children. We investigated whether music and language activities in early childhood are associated with improved developmental outcomes of preterm-born children.MethodsThe cognitive, language, and motor skills of 45 children, born between 24 and 34 gestational weeks, were tested at 23–38 months of corrected age with the Bayley Scales of Infant and Toddler Development, Third Edition. Background information, including parental education, and the weekly amount of music and language-related activities was collected using parental questionnaires.ResultsThe amount of singing, playing musical instruments and reading aloud was associated with better language skills. Moreover, children who had participated in a music playschool had better language skills when compared to those children who had not participated in a music playschool. Maternal education was associated with music playschool participation and better language and motor skills in children attending music playschool.DiscussionInteractive music and language activities in early childhood may improve language skills in preterm-born children. Informing and guiding parents at an early stage to integrate these activities into their daily lives could be a one way of supporting the development of preterm-born children.
National trends in loneliness and social isolation in older adults: an examination of subgroup trends over three decades in Sweden
Authors: Dahlberg Lena , von Saenger Isabelle , Naseer Mahwish , Lennartsson Carin , Agahi Neda 
Published: September 2024

IntroductionLoneliness and social isolation are public health concerns. This study aimed to examine levels and trends in loneliness and social isolation among older adults (77+ years) in Sweden, assess subgroup variations, and determine associations between loneliness and social isolation.MethodsThe 1992, 2002, 2004, 2011, 2014 and 2021 waves of the Swedish Panel Study of Living Conditions of the Oldest Old (SWEOLD) were analysed through ordered logistic and linear regressions.ResultsOn average, 12.5 percent of the participants experienced loneliness often/nearly always, while 6 percent were categorised as severely isolated. Loneliness and social isolation were more common in women, those aged 85+, and persons with basic education, in psychological distress or with mobility limitations. Loneliness was also associated with living alone. No increases in loneliness or isolation were identified; instead, loneliness tended to decrease in groups already experiencing lower levels of loneliness. Loneliness and social isolation were moderately associated each survey year.DiscussionThis study challenges perceptions of high and increasing levels of loneliness and social isolation. Given the impact on health and wellbeing and the ageing of populations, policy and practice should still address these issues and target vulnerable groups. Subgroup analyses in trends are scarce and should be explored further in future research.
“Still Cool as a Zombie”: Community, the Zombie Aesthetic, and the Politics of Belonging
Authors: Cox Colin A. 
Published: September 2024

From Night of the Living Dead (1968) to The Walking Dead (2010–2022), zombie media offers a consistent refrain, namely to avoid becoming a zombie. This refrain makes intuitive sense. Why would anyone welcome becoming a member of a roaming, mindless, and often violent undead horde symbolizing humanity’s destruction? However, zombification has affirmative, emancipatory possibilities. In “Epidemiology,” from Season 2 of the NBC sitcom Community (2009–2015), we see the zombie’s affirmative and emancipatory potential. In this essay, I argue zombification enlivens Community by provoking the show to rethink its relationship to its nominal protagonist, Jeff Winger, and to itself as a piece of avant-garde comedy television produced during the “Golden Age of Television,” what media scholars also call, “Peak” or “Prestige TV.” In this episode, Community evolves its understanding of its central protagonist by shifting, in some respects, from a conventional and historically predictable character to a character far less conventional.
Dormancy-Related Bioactive Compounds and Antioxidant Activity during Optimization of Germination Conditions for Onopordum nervosum subsp. platylepis Murb. Using Response Surface Methodology
Authors: Dhen Najla , Kouki Rania , Bziouech Samra Akef , Essaidi Ismahen , Naffati Lamia , Haouala Faouzi , Alhudhaibi Abdulrahman M. , Alrudayni Hassan A. , Kammoun Mariem , Al Mohandes Dridi Bouthaina 
Published: September 2024

Onopordum nervosum subsp. platylepis Murb. is an Asteraceae species found in Tunisia, Algeria, and Libya. It has been studied for its potential use as a vegetable rennet alternative to animal-derived rennet, making it important to understand its germination characteristics. This species often shows low germinability due to dormancy, which limits its large-scale cultivation. In preliminary experiments, many factors were analyzed to evaluate the seed germination of this thistle including physical stratification with abrasive paper and high-temperature water, chemical treatments with hydrogen peroxide (H2O2) or sulfuric acid (H2SO4), and the exogenous use of the growth regulator gibberellic acid (GA3). Based on the obtained results and subsequent analysis, GA3 and cold stratification durations were selected for the second experiment, which used a full factorial RSM design with three levels for each factor. Additionally, the total polyphenol content (TPC), total flavonoid content (TFC), condensed tannin content (CTC), and DPPH assay were analyzed during the optimization process and for ungerminated seeds. The findings revealed that 14 days of cold stratification followed by 750 ppm GA3 was the most efficient method for breaking the dormancy of these thistle seeds. The highest TPC was recorded in ungerminated seeds. However, germinated Onopordum nervosum ssp. platylepis seeds showed higher levels of TFC and CTC (14.83 mg QE/g DW and 6.49 mg EC/g DW, respectively) compared to the non-germinated ones and demonstrated the greatest potency in inhibiting free radicals (DPPH EC50 = 0.018 mg/mL) at the identified optimal germination conditions. Ungerminated seeds indicated significant phenolic content (TPC) and a limited ability to reduce oxidants, which could explain their low germination percentage. Our findings on the seed germination and dormancy characteristics of this endemic thistle will aid in the protection and development of its germplasm.
A atuação do agente de contratação nas contratações diretas, segundo o Regulamento Estadual do Paraná, à Lei nº 14.133, de 2021
Authors: Dal’Apria George Luiz 
Published: September 2024

A realização de licitação é regra constitucional para as contratações públicas, admitindo exceções, permitindo a contratação direta quando inviável a competição ou, quando expressamente dispensada pela lei federal, que dita as normas gerais de licitações e contratos administrativos. Constitucionalmente, admite-se sua suplementação por lei estadual ou regulamentação por decreto. As normas gerais preconizam a necessidade de segregação das funções, atribuindo-se a agentes distintos àquelas mais suscetíveis a riscos criando a figura do agente de contratação a lei lhe incumbe da condução da licitação. O regulamento do Estado do Paraná é feito por decreto estadual, que incumbe ao agente de contratação também a instrução e condução das contratações diretas, que é um processo formalmente distinto da licitação, sem esclarecer exatamente quais são as atribuições. Objetiva-se portanto, identificar os procedimentos cabíveis ao agente, por meio de revisão bibliográfica e análise do texto legal e normativo, sendo possível identificar os procedimentos afetos e assemelhados que devem ser realizados pelo agente de contratação.
Rancang bangun alat pemanen madu berbasis konduktivitas
Authors: Sutanto Sutanto , Widjajanto Danang , Kusumastuti Sri Lestari 
Published: September 2024

Budidaya lebah sebagai sumber utama penghasil madu sudah banyak dilakukan oleh masyarakat secara berkelompok atau secara individu. Pada saat memanen madu sebagian besar petani lebah masih dilakukan secara tradisional, yaitu dengan menekan kantung madu dengan sendok di atas saringan. Dengan demikian diperlukan waktu proses yang cukup lama dan sebagian madu masih ada yang tertinggal dalam kantung madu. Oleh karena itu, waktu yang digunakan untuk memanen madu menjadi kurang efisien dan madu yang diperoleh kurang optimum. Untuk membantu mempercepat proses pemanenan dan mengoptimumkan perolehan madu, maka dibuat alat pemanen madu berbentuk silinder yang dilengkapi piringan penekan kantung madu dari bahan baja tahan karat SS 304 yang dapat digerakkan naik atau turun secara manual dan dilengkapi alat konduktotometer untuk mendeteksi sisa madu dalam kantung madu. Hasil pengujian menunjukkan bahwa pada pemrosesan kantung madu 10 gram, 20 gram dan 30 gram alat mampu menghasilkan cairan madu masing-masing 5,4 mL, 10,3 mL dan 15,8 mL. Rendemen rata-rata 47,6%, kandungan air rata-rata 8,68%, dan konduktivitas rata-rata madu dalam kantung madu 19,5 uS/cm.
Taboo Words in Medan Local Language
Authors: SYAHDANI RURI ALFIA 
Published: September 2024

This research aimed to find out the types of taboo words, described the meaning of taboo words and each types to find the results of the percentage and dominant of taboo words. The research method used in completing this thesis was descriptive qualitative approach. In analyzing the data, theory of Wardhaugh (2006) was used to classifies the categories of taboo words and types of the informants utterances. This research used the method of interviews by the informants as sociolinguistics approach and use a field research in Medan local language. The result of this research showed that there were 14 data that has been classifies into the types of taboo words where the dominant was death and excretion (28,58%) with each 4 (four) data. Next, followed by sex term with 3 (three) data, body function with 3 (three) data, religious matter with nol data, and politics with nol data.
The Teenagers Perception on The Playing of Atlantica Online Game in English Vocabulary Mastery
Authors: Butar-Butar Jhuan Carlos , Ilmi Djauzi 
Published: September 2024

This Thesis entitled “The Teenagers’ Perception on The Playing of Atlantica Online Game in English Vocabulary Mastery” This is a research of the influence of online gaming in the development of English vocabulary mastery teenagers. The purpose of research is that today’s teenagers play games not just for fun, we can learn English while playing games. This research uses qualitative methods. This research uses behaviorism theory. This research is conducted in Medan and several gamers became participant. Data of the research are the words contained in Atlantica Online, books, journal, and article who made inquiries to find meaning in Indonesian. The data source of this thesis is online game ‘Atlantica Online’. To make easy the finding of research results, the researcher use tables and diagrams. The results showed that, how frequently teenagers influential within understanding the vocabulary mastery contained in Atlantica Online.
Room temperature nanoimprint aided by electron beam irradiation for polysilsesquioxane
Authors: Yasui Manabu , Nishi Yoshitake , Kurouchi Masahito , Kaneko Satoru , Mitsuhashi Masahiko 
Published: September 2024

Abstract
Recently, the application of inorganic nano-periodic structures has become an active area of research. Polysilsesquioxane (PSQ) is known as a hydrolytically stable organic-inorganic hybrid material and this study proposes RT nanoimprint using methylated poly silsesquioxane (Me-PSQ) dissolved in a high-boiling solvent. PSQ electron beam cross-linked by a high electron beam irradiation maintained the shape of nanopatterns and enhanced the heat resistance. As a result of the analysis of the Fourier transform infrared spectrophotometer (FT-IR), a siloxane linkage (Si-O-Si bridging) constitutes a core element of PSQ. The peak wavenumber of Si-O-Si bridging at cross-linked PSQ by electron beam irradiation shifted from 1115 to 1135 cm−1. The peaks shifted towards the high wavenumber side and approached the second peak (1170 cm−1) of the Si-O-Si stretching vibration of quartz. This result suggests that the physical properties of electron-beam irradiated PSQ approach those of quartz.