bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epidemiology of infertility in China: a population‐based study
Authors: Zhou Z , Zheng D , Wu H , Li R , Xu S , Kang Y , Cao Y , Chen X , Zhu Y , Xu S , Chen Z‐J , Mol BW , Qiao J 
Published: October 2017

ObjectiveTo assess the current prevalence of and risk factors for infertility among couples of reproductive age in China.DesignPopulation‐based cross‐sectional study.SettingWe approached 25 270 couples in eight provinces/municipalities, of whom 18 571 (response rate 74%) were interviewed.PopulationCouples living together and married for more than 1 year, of whom the female spouse was 20–49 years old.MethodsWomen were approached via telephone and face‐to‐face conversation to complete the standardised and structured questionnaire by trained interviewers.Main outcome measuresPrevalence of and risk factors for infertility.ResultsAmong women ‘at risk’ of pregnancy, the prevalence of infertility was 15.5% (2680/17 275). Among 10 742 women attempting to become pregnant, the prevalence of infertility was 25.0% (2680/10 742), which increased with age in the second population. Among women who failed to achieve pregnancy in the last 12 months, 3470 finished our questionnaire about fertility care, and 55.2% (1915/3470) of them had sought medical help. Sociodemographic risk factors for infertility included lower educational level [adjusted odds ratio (aOR) 3.4, 95% CI 2.0–5.5] and employment (aOR 2.3, 95% CI 1.9–2.9). Clinical risk factors were irregular menstrual cycle (aOR 1.8, 95% CI 1.2–2.5), light menstrual blood volume (aOR 1.6, 95% CI 1.2–2.0), history of cervicitis (aOR 1.5, 95% CI 1.2–2.0) and endometriosis (aOR 3.1, 95% CI 1.1–9.3), previous stillbirth (aOR 2.1, 95% CI 1.3–3.3) and miscarriage (aOR 2.7, 95% CI 2.1–3.5). In addition, history of operation was a significant risk factor of infertility.ConclusionsAmong couples of reproductive age in China, the prevalence of infertility was 25%, and almost half of the couples experiencing infertility had not sought medical help.Tweetable abstractIn China, 25% of couples actively attempting to become pregnant suffered infertility.
The Effects of Short‐Time Temperature Abuse on the Microbial and Sensory Quality of Chilled Saithe (Pollachius virens) Fillets
Authors: Mu Gang , Jonsson Asbjorn , Bergsson Arnljotur B. , Thorarinsdottir Kristin A. 
Published: October 2017

AbstractChilled fish products are highly perishable with a limited shelf life (10 to 14 d). For this reason, the control of the cold chain for fish is essential. This study´s objective was to investigate the effects of short‐time temperature abuse during processing on spoilage of chilled saithe (Pollachius virens) fillets. Analysis of microbial growth, freshness grades, and sensory score by Quality Index method, as well as pH, were carried out during a 10‐d storage period at 2 ± 2 °C. Before storage, the fillets were kept at 16 °C for 0, 1, and 2 h. The results showed that spoilage of the fillets was accelerated with longer holding time at 16 °C. The 1‐ and 2‐h holding before packing and storage caused a 22% (2 d) and 44% (4 d) loss of shelf life, respectively, compared to fillets that were packed immediately after processing. These findings indicate how bottlenecks and delays during processing may result in loss of microbial and sensory quality of chilled fish products.Practical ApplicationThe observations show the importance of maintaining a low temperature in fish, even for a short period such as during processing. Any delays, such as due to buffering or mechanical failure, may accelerate spoilage of chilled products during subsequent storage. This effect is even more pronounced when products are packed in bulk volumes as the cooling rate is much slower than the piece‐by‐piece cooling rate.
Establishing Standards on Colors from Natural Sources
Authors: Simon James E. , Decker Eric A. , Ferruzzi Mario G. , Giusti M. Monica , Mejia Carla D. , Goldschmidt Mark , Talcott Stephen T. 
Published: October 2017

AbstractColor additives are applied to many food, drug, and cosmetic products. With up to 85% of consumer buying decisions potentially influenced by color, appropriate application of color additives and their safety is critical. Color additives are defined by the U.S. Federal Food, Drug, and Cosmetic Act (FD&C Act) as any dye, pigment, or substance that can impart color to a food, drug, or cosmetic or to the human body. Under current U.S. Food and Drug Administration (FDA) regulations, colors fall into 2 categories as those subject to an FDA certification process and those that are exempt from certification often referred to as “natural” colors by consumers because they are sourced from plants, minerals, and animals. Certified colors have been used for decades in food and beverage products, but consumer interest in natural colors is leading market applications. However, the popularity of natural colors has also opened a door for both unintentional and intentional economic adulteration. Whereas FDA certifications for synthetic dyes and lakes involve strict quality control, natural colors are not evaluated by the FDA and often lack clear definitions and industry accepted quality and safety specifications. A significant risk of adulteration of natural colors exists, ranging from simple misbranding or misuse of the term “natural” on a product label to potentially serious cases of physical, chemical, and/or microbial contamination from raw material sources, improper processing methods, or intentional postproduction adulteration. Consistent industry‐wide safety standards are needed to address the manufacturing, processing, application, and international trade of colors from natural sources to ensure quality and safety throughout the supply chain.
Protection of Grain Products from Sitophilus oryzae (L.) Contamination by Anti‐Insect Pest Repellent Sachet Containing Allyl Mercaptan Microcapsule
Authors: Chang Yoonjee , Lee Soo‐Hyun , Na Ja Hyun , Chang Pahn‐Shick , Han Jaejoon 
Published: October 2017

AbstractThe purpose of this study was to develop an anti‐insect pest repellent sachet to prevent Sitophilus oryzae (L.) (Coleoptera: Curculionidae) contamination in grain packaging. The anti‐insect pest activities of essential oils (EOs) from garlic (Allium Sativum), ginger (Zingiber Officinalis), black pepper (Piper nigrum), onion (Allium cepa), and fennel (Foeniculum vulgare) as well as major compounds (allyl disulfide, AD; allyl mercaptan, AM) isolated from of garlic and onion (AD and AM) were measured against S. oryzae. The results revealed that garlic EO, onion EO, AD, and AM showed strong fumigant insecticidal activities. Among these, AM showed the highest acetylcholinesterase (AChE) inhibition rate, indicating that the fumigation insecticidal efficacy of AM is related with its AChE inhibition ability. Subsequently, the microcapsules were produced with a high efficiency (80.02%) by using AM as a core material and rice flour as a wall material. Finally, sachet composed of rice flour microcapsule containing 2% AM (RAM) was produced. Repellent assay was performed to measure anti‐insect pest ability of the RAM sachet, showed remarkable repelling effect within 48 h both in the presence or absence of attractant. In a release profile of RAM sachet, it was expected to last over 20 mo during the distribution period of brown rice. Moreover, RAM sachet showed no undesirable changes to the sensory properties of the rice both before and after cooking. Taken together, these results suggest that the newly developed RAM sachet could be used as a packaging material to protect grain products from S. oryzae contamination.Practical ApplicationThe rice weevil, Sitophilus oryzae (L.) (Coleoptera: Curculionidae), causes damages to stored products and its contamination in grain products has become a major problem in cereal market. To preserve brown rice, an anti‐insect pest repellent sachet containing 2% allyl mercaptan was newly developed and it showed remarkable repellent abilities against S. oryzae. It could be used as an active food packaging system to protect grain products from insect pest contamination.
Characterization of Sensory Differences in Mixing and Premium Rums Through the Use of Descriptive Sensory Analysis
Authors: Ickes Chelsea M. , Cadwallader Keith R. 
Published: October 2017

AbstractThis study identified and quantitated perceived sensory differences between 7 premium rums and 2 mixing rums using a hybrid of the Quantitative Descriptive Analysis and Spectrum methods. In addition, the results of this study validated the previously developed rum flavor wheel created from web‐based materials. Results showed that the use of the rum flavor wheel aided in sensory term generation, as 17 additional terms were generated after the wheel was provided to panelists. Thirty‐eight sensory terms encompassing aroma, aroma‐by‐mouth, mouthfeel, taste and aftertaste modalities, were generated and evaluated by the panel. Of the finalized terms, only 5 did not exist previously on the rum flavor wheel. Twenty attributes were found to be significantly different among rums. The majority of rums showed similar aroma profiles with the exception of 2 rums, which were characterized by higher perceived intensities of brown sugar, caramel, vanilla, and chocolate aroma, caramel, maple, and vanilla aroma‐by‐mouth and caramel aftertaste.Practical ApplicationThese results demonstrate the previously developed rum flavor wheel can be used to adequately describe the flavor profile of rum. Additionally, results of this study document the sensory differences among premium rums and may be used to correlate with analytical data to better understand how changes in chemical composition of the product affect sensory perception.
Resistance training reduces metabolic syndrome and inflammatory markers in older women: A randomized controlled trial
Authors: Tomeleri Crisieli M. , Souza Mariana F. , Burini Roberto C. , Cavaglieri Cláudia R. , Ribeiro Alex S. , Antunes Melissa , Nunes João P. , Venturini Danielle , Barbosa Décio S. , Sardinha Luís B. , Cyrino Edilson S. 
Published: October 2017

AbstractBackgroundThis study analyzed the effects of a 12‐week resistance training (RT) program without dietary interventions on metabolic syndrome (MetS) components and inflammatory biomarkers in older women.MethodsFifty‐three older women (mean [±SD] age 70.4 ± 5.7 years; mean body mass index 26.7 ± 4.0 kg/m2) were randomly assigned to a training group (TG; n = 26) that performed 12 weeks of an RT program or a control group (CG; n = 27) that did not perform any type of physical exercise over the same period. Body composition (dual energy X‐ray absorptiometry), muscular strength (one‐repetition maximum tests), blood pressure (BP), and blood sample measurements were performed before and after intervention.ResultsAfter the 12‐week period, there were significantly reductions (P < 0.05) in glucose levels (−20.4% vs −0.3%), waist circumference (−1.5% vs +2.0%), and systolic BP (−6.2% vs +0.9%), and complete normalization of MetS prevalence (18% at baseline vs. 0% after 12‐weeks RT) in the TG. Moreover, C‐reactive protein and tumor necrosis factor‐α concentrations decreased in the TG (−28.6% and −21.6%, respectively), but increased in the CG (+34.5% and +13.3%, respectively). In addition there were positive improvements in the MetS Z‐score in the TG but not CG (−21.6% vs +13.3%, respectively).ConclusionThe results suggest that a 12‐week RT program seems to effectively reduce MetS components and inflammatory biomarkers in older women, regardless of dietary intervention. The RT‐induced adaptations in body composition and inflammatory biomarkers appear to be related to healthy adaptations in risk factors for MetS.
Re‐examining the sensitivity of HbA1c to screen for diabetes mellitus
Authors: Yap Chun W. , Ang Yee G. , Quek Timothy P.L. , Heng Bee H. , Chew Daniel E.K. 
Published: October 2017

AbstractBackgroundOne of the laboratory tests recommended by the American Diabetes Association (ADA) to screen for diabetes mellitus (DM) is HbA1c, and it is particularly suitable for segments of the population that cannot or are unwilling to fast for a screening test. The aim of this study was to determine whether HbA1c would be a useful tool to screen for DM in a real‐world setting if ADA guidelines for repeat testing to confirm the diagnosis of DM are strictly adhered to.MethodsA retrospective database study was performed by extracting demographic and laboratory data from a chronic disease registry that collects data on adults from three tertiary hospitals and nine large primary care clinics in Singapore. Data were extracted and analyzed for adults not previously known to have DM whose data was captured in the registry between 2005 and 2016 with HbA1c and at least two diagnostic tests for DM (fasting plasma glucose or 2‐h plasma glucose) performed within 4 weeks after HbA1c determination.ResultsIn all, 3928 adults were included in this study. The sensitivity, specificity, and area under the receiver operating characteristic curve for HbA1c at a threshold of 6.5% were 85.2%, 82.3%, and 0.914, respectively. A higher sensitivity was found in female adults, younger adults, and those of non‐Chinese ethnicity.ConclusionsThe sensitivity of HbA1c as a screening test for DM in this study was significantly higher than that reported previously. This work provides additional evidence supporting the inclusion of HbA1c as one of the screening tests for DM.
Beneficial Effect of Alcohol Withdrawal on Gut Permeability and Microbial Translocation in Patients with Alcohol Use Disorder
Authors: Donnadieu‐Rigole Hélène , Pansu Nathalie , Mura Thibault , Pelletier Stéphanie , Alarcon Régis , Gamon Lucie , Perney Pascal , Apparailly Florence , Lavigne Jean‐Philippe , Dunyach‐Remy Catherine 
Published: October 2017

BackgroundThe human intestinal microbiota exerts beneficial or harmful effects in several disorders. Many factors, including alcohol consumption, may influence its composition and trigger bacterial translocation. Excessive alcohol consumption increases gut permeability and translocation of endotoxin into peripheral circulation. Although plasma endotoxin concentrations have been measured often, quantitative changes following alcohol withdrawal have never been described in subjects with alcohol use disorder (AUD). The aim of this study was to measure microbial translocation (MT) and gut permeability markers in patients with AUD, to compare these markers to healthy controls (HC) and to monitor markers during the first 6 weeks of abstinence.MethodsSixty‐five patients with AUD and hospitalized for alcohol withdrawal were included. Epidemiological, clinical, biological, and addictological data were gathered. Blood samples were collected at baseline, then 3 and 6 weeks after alcohol withdrawal. A hundred healthy volunteers were used as controls. Three markers of MT were monitored in plasma samples: sCD14 and lipopolysaccharide‐binding protein (LBP) were quantified using ELISA, and 16S rDNA was quantified using real‐time polymerase chain reaction. Zonulin and intestinal fatty acid binding protein (I‐FABP) blood levels were also monitored as indirect markers of gut permeability, using ELISA.ResultsAt baseline, LBP, 16S rDNA, sCD14 and I‐FABP markers were significantly higher in patients with AUD than in HC. Six weeks after alcohol withdrawal plasma levels of sCD14 and LBP decreased significantly. Cannabis consumption and body mass index (BMI) before alcohol withdrawal influenced baseline MT levels and the decrease in MT markers after 6 weeks. Finally, markers of MT and gut permeability did not correlate with each other before and after alcohol withdrawal.ConclusionsBefore alcohol withdrawal, MT markers were higher in patients with AUD than in HC. After 6 weeks of abstinence, an improvement in MT markers was observed. Our data suggest that there is a link between MT, its improvement, BMI, and cannabis consumption.
Baseline fragmented QRS increases the risk of major arrhythmic events in Brugada syndrome: Systematic review and meta‐analysis
Authors: Rattanawong Pattara , Riangwiwat Tanawan , Prasitlumkum Narut , Limpruttidham Nath , Kanjanahattakij Napatt , Chongsathidkiet Pakawat , Vutthikraivit Wasawat , Chung Eugene H. 
Published: October 2017

BackgroundFragmented QRS reflects disturbances in the myocardium predisposing the heart to ventricular tachyarrhythmias. Recent studies suggest that fragmented QRS (fQRS) is associated with major arrhythmic events in Brugada syndrome. However, a systematic review and meta‐analysis of the literature has not been done. We assessed the association between fQRS and major arrhythmic events in Brugada syndrome by a systematic review of the literature and a meta‐analysis.MethodsWe comprehensively searched the databases of MEDLINE and EMBASE from inception to May 2017. Included studies were published prospective or retrospective cohort studies that compared major arrhythmic events (ventricular fibrillation, sustained ventricular tachycardia, sudden cardiac arrest, or sudden cardiac death) in Brugada syndrome with fQRS versus normal QRS. Data from each study were combined using the random‐effects, generic inverse variance method of DerSimonian and Laird to calculate risk ratios and 95% confidence intervals.ResultsNine studies from January 2012 to May 2017 were included in this meta‐analysis involving 2,360 subjects with Brugada syndrome (550 fQRS and 1,810 non‐fQRS). Fragmented QRS was associated with major arrhythmic events (pooled risk ratio =3.36, 95% confidence interval: 2.09‐5.38, p < .001, I2 = 50.9%) as well as fatal arrhythmia (pooled risk ratio =3.09, 95% confidence interval: 1.40‐6.86, p = .005, I2 = 69.7%).ConclusionsBaseline fQRS increased major arrhythmic events up to 3‐fold. Our study suggests that fQRS could be an important tool for risk assessment in patients with Brugada syndrome.
Racial disparities in comorbidity and severe maternal morbidity/mortality in the United States: an analysis of temporal trends
Authors: Metcalfe Amy , Wick James , Ronksley Paul 
Published: October 2017

AbstractIntroductionSevere maternal morbidity and mortality have increased in the USA in recent years. This trend has not been consistent across all racial groups. The reasons behind this, and the relation between preexisting conditions, pregnancy‐associated disease and severe maternal morbidity/mortality, have not been fully explored.Material and methodsAnnual data on delivery hospitalizations between 1993 and 2012 were obtained from the Nationwide Inpatient Sample (NIS), representing a 20% sample of hospital discharges from across the USA. Chi‐square tests for trend were used to examine temporal patterns in the proportion of pregnancies affected by comorbidities as defined by the Obstetric Comorbidity Score and were stratified by maternal race. Logistic regression was used to determine the impact of temporal increases in comorbidity on severe maternal morbidity/mortality.ResultsIn 1993, 34.3% of pregnancies had a comorbidity score of ≥1; this significantly increased to 44.1% by 2012 (p < 0.001). Baseline differences were observed between all races (Whites 33.7%, Blacks 34.5%, Hispanics 28.0%, Asian/Pacific Islanders 28.1%). Although significant increases were observed for all races, the relative rate of change was lowest for Whites (26.1% increase) and highest for Asian/Pacific Islanders (49.1% increase). The odds of severe maternal morbidity/mortality have steadily increased over time; however, adjustment for Obstetric Comorbidity Score significantly attenuates this correlation.ConclusionThe rate of both preexisting comorbidities and pregnancy‐associated disease is increasing in pregnant women in the USA and varies substantially by race. These trends provide valuable insight into the increasing complexity of pregnancy in the USA and explain a proportion of the observed increase in severe maternal morbidity/mortality.
Preoperative methylprednisolone increases plasma Pentraxin 3 early after total knee arthroplasty: a randomized, double-blind, placebo-controlled trial
Authors: Lindberg-Larsen V , Kehlet H , Pilely K , Bagger J , Rovsing M L , Garred P 
Published: October 2017

Summary
Preoperative glucocorticoid administration reduces the systemic inflammatory response. Pentraxin 3 (PTX3) is a novel inflammatory marker belonging to the humoral arm of innate immunity exerting a potentially protective host response. This study evaluated PTX3 and other complement marker changes after preoperative methylprednisolone (MP) early after total knee arthroplasty (TKA). Seventy patients were randomized (1 : 1) to preoperative intravenous (i.v.) MP 125 mg (group MP) or isotonic saline i.v. (group C). The outcomes included change in plasma PTX3, mannose-binding lectin (MBL), ficolins (ficolin-1, −2 and −3), complement components (C4 and C3), terminal complement complex (TCC) and C-reactive protein (CRP) concentrations. Blood samples were analysed at baseline and 2, 6, 24 and 48 h after surgery with complete sampling from 63 patients for analyses. MP resulted in an increase in circulating PTX3 compared to saline from baseline to 24 h postoperatively (P &lt; 0·001), while MP reduced the systemic inflammatory response (CRP) 24 and 48 h postoperatively (P &lt; 0·001). However, the small postoperative changes in MBL, ficolin-1, −2 and −3, C4, C3 and TCC concentrations did not differ between groups (P &gt; 0·05). In conclusion, preoperative MP 125 mg increased circulating PTX3 and reduced the general inflammatory response (CRP) early after TKA, but did not affect other complement markers.
Association ofMEOX2polymorphism with nonsyndromic cleft palate only in a Vietnamese population
Authors: Tran Duy L. , Imura Hideto , Mori Akihiro , Suzuki Satoshi , Niimi Teruyuki , Ono Maya , Sakuma Chisato , Nakahara Shinichi , Nguyen Tham T.H. , Pham Phuong T. , Hoang Viet , Tran Van T.T. , Nguyen Minh D. , Natsume Nagato 
Published: October 2017

ABSTRACTTo evaluate the association between the single nucleotide polymorphism (SNP) rs227493 in theMEOX2gene and nonsyndromic cleft palate only, this research was conducted as a case–control study by comparing a nonsyndromic cleft palate only group with an independent, healthy, and unaffected control group who were both examined by specialists. Based on clinical examination and medical records, we analyzed a total of 570 DNA samples, including 277 cases and 293 controls, which were extracted from dry blood spot samples collected from both the Odonto and Maxillofacial Hospital in Ho Chi Minh City and Nguyen Dinh Chieu Hospital in Ben Tre province, respectively. The standard procedures of genotyping the specific SNP (rs2237493) forMEOX2were performed on a StepOne Realtime PCR system with TaqMan SNP Genotyping Assays. Significant statistical differences were observed in allelic frequencies (allele T and allele G) between the non‐syndromic cleft palate only and control groups in female subjects, with an allelic odds ratio of 1.455 (95% confidence interval: 1.026–2.064) andP < 0.05. These study findings suggest that nonsyndromic isolated cleft palate might be influenced by variation ofMEOX2, especially SNP rs2237493 in Vietnamese females.