bluuebunny/crossref_metadata_2025_split huggingface dataset:
Belimumab 10 years later: how drug positioning has changed
Authors: Ceccarelli Fulvia , Natalucci Francesco , Ciancarella Claudia , Picciariello Licia , Moretti Valeria , Spinelli Francesca Romana , Alessandri Cristiano , Conti Fabrizio 
Published: October 2024

AbstractWe analysed the change in the positioning of belimumab (BLM) in systemic lupus erythematosus (SLE) treatment in the first decade of real-life use, by providing data about patients treated by this biological drug in the Sapienza Lupus Cohort. We evaluated SLE patients treated by BLM according to the current clinical practice. Data of each patient were collected, focusing on previous and concomitant treatments. Finally, the drug retention rate was assessed. Since August 2013, 138 SLE patients started BLM (M/F 7/131; median age 49 years, IQR 13.25; median disease duration 214 months, IQR 180). To evaluate the change in BLM positioning, we divided patients according to the date of starting treatment as below: patients treated from 2013 to 2018 (period 1) and those treated since 2019 to date (period 2). Indeed, the median number of previous immunosuppressant drugs was significantly higher in patients treated in period 1 [3 (IQR 1.25) versus 1 (IQR 1.75), p = 0.0002]. Furthermore, 15.9% of patients treated in period 2 were not previously treated by immunosuppressant drugs, compared with 5.2% in period 1 (p = 0.01). Finally, the 24-month drug survival was significantly higher in patients previously treated with ≤ 1 immunosuppressant drug in comparison with those treated with ≥ 2 drugs (69.1% versus 43.4%, p = 0.0097, HR 0.49; 95% CI 0.27–0.88). Our data clearly described the progressive anticipation of BLM prescription in the first 10 years of clinical practice, underlining as choosing earlier biological agents could positively influence the drug retention rate.
Strategic implications of the US-China semiconductor rivalry
Authors: Hamdani Manal , Belfencha Ismail 
Published: October 2024

AbstractThe ongoing trade war between China and the United States has had a far-reaching impact on a global scale. This rivalry has been most obvious in the semiconductor industry. The two nations have found themselves in a tense geopolitical situation where any economic attack by either side would affect all parties involved. This paper aims to explore the origins of this conflict and highlight the key actions taken by each country, as well as the consequences of those actions. Additionally, it highlights the areas of interdependence between China and the US (i.e., American high-tech chips and Chinese rare earth materials). The study utilizes the theory of weaponizing independence and game theory’s Prisoner’s Dilemma to conclude that while both China and the US have suffered negative consequences due to this conflict, China's latest technological advancements in the 7nm chip and their supply of rare earth materials have given them a stronger hand in the game.
Drug-like screening, molecular docking, molecular dynamics simulations, and binding free energies on the interaction of pyrazole derivatives as inhibitors of lysosomal storage disorders and anticancer activity
Authors: Edache Emmanuel Israel , Adedayo Adebiyi , Dawi Hadiza Adamu , Ugbe Fabian Audu 
Published: October 2024

AbstractLysosomal membrane proteins (LAMPs) are a primary target for treating tumors because of their essential role in the cancer life cycle. In this study, some computational approaches, including drug-like screening, molecular docking, and molecular dynamics (MD) simulation studies coupled with the binding free energy, have been conducted to explore the putative binding modes of pyrazole derivatives as inhibitors of lysosomal storage disorders. Certain pyrazole derivatives outperformed typical medications in molecular docking experiments against the LAMPs receptor; among other substances, molecules CID 44555488 and 45,487,645 were deemed ideal. Additionally, these ligands (CID 44555488 and 45,487,645) were projected to be orally accessible in humans after successfully passing five separate drug-likeness criteria. In the end, it was anticipated that these ligands, CID 44555488 and 45,487,645, would have minimal human toxicity and good ADMET properties, particularly in terms of GI absorption and the lack of P-gp interaction. Compounds CID 44555488 and 45,487,645 with high predicted binding affinities were subjected to further molecular dynamics simulations based on the molecular docking data, and their potential binding mechanisms were investigated. The study's description of the structure-based drug design approach will be very helpful in the creation of novel inhibitors with excellent selectivity and potency.
Incidence angle dependency and seasonal evolution of L and C-band SAR backscatter over landfast sea ice
Authors: Karlsen Truls , Johansson Malin , Lohse Johannes , Doulgeris Anthony P. 
Published: October 2024

Abstract
We estimate sea-ice type specific incidence angle (IA) dependencies for dual polarized (HH/HV) L and C-band synthetic aperture radar (SAR) for the winter, melt onset and advanced melt seasons for level and deformed ice, using time-series of Advanced Land Observing Satellite-2 (ALOS-2) and Sentinel-1 imagery off the north-east coast of Greenland. The IA dependencies are used to radiometrically correct the L and C-band backscatter time-series, which enables analysis of their seasonal evolution. From this, we observe that the L-band backscatter intensity increases for both ice types at the transition from winter to melt onset. We use these results to estimate ice type separability and to train an IA aware Bayesian classifier at both frequencies. These results show that while both frequencies are capable of distinguishing level and deformed ice during the winter, only L-band SAR can reliably make this separation during the melt onset season. During the advanced melt season, the overall classification accuracies are similarly low for L and C-band. This study demonstrates the potential of L-band SAR for sea-ice mapping, which is highly relevant in the light of several upcoming L-band SAR missions.
Daniel Kahneman and the concept of the true self
Authors: Sugden Robert 
Published: October 2024

Abstract
Kahneman and Tversky's ‘Prospect Theory’ paper famously demolishes expected utility theory as a predictive device. However, it presents deviations from that theory as ‘normatively unacceptable’ and argues that decision-makers would normally correct them when possible. In a later paper, Kahneman rejects a similar argument (the ‘discovered preference’ hypothesis) advanced by Plott. Later still, Kahneman endorses Sunstein and Thaler's ‘libertarian paternalism’, which aims to help people avoid deviating from their ‘true’ preferences. I report an email correspondence between Kahneman and me in which we debated whether his position on libertarian paternalism was consistent with his critique of Plott's hypothesis.
The Translational Science Benefits Model, a new training tool for demonstrating implementation science impact: A pilot study
Authors: Andersen Stephanie , Wilson Annalee , Combs Todd , Brossart Laura , Heidbreder Julie , McCrary Stacey , Beidas Rinad S. , Cabassa Leopoldo J. , Finley Erin P. , McGinty Emma E. , Purtle Jonathan , Saldana Lisa , Proctor Enola , Luke Douglas 
Published: October 2024

Abstract

Introduction:
Demonstrating the impact of implementation science presents a new frontier for the field, and operationalizing downstream impact is challenging. The Translational Science Benefits Model (TSBM) offers a new approach for assessing and demonstrating research impact. Here we describe integration of the TSBM into a mentored training network.

Methods:
Washington University’s Clinical and Translational Science Awards TSBM team collaborated with a National Institute of Mental Health-supported training program, the Implementation Research Institute (IRI), a 2-year training institute in mental health implementation science. This partnership included three phases: (1) introductory workshop on research impact, (2) workshop on demonstrating impact, and (3) sessions to guide dissemination, including interactive tools and consultation with the TSBM research team. Fifteen IRI alumni were invited to participate in the pilot; six responded agreeing to participate in the training, develop TSBM case studies, and provide feedback about their experiences. Participants applied the tools and gave feedback on design, usability, and content. We present their case studies and describe how the IRI used the results to incorporate TSBM into future trainings.

Results:
The case studies identified 40 benefits spanning all four TSBM domains, including 21 community, 11 policy, five economic, and three clinical benefits. Participants reported that TSBM training helped them develop a framework for talking about impact. Selecting benefits was challenging for early-stage projects, suggesting the importance of early training.

Conclusions:
The case studies showcased the institute’s impact and the fellows’ work and informed refinement of tools and methods for incorporating TSBM into future IRI training.
Predicting the geographical potential distribution of species Opisina arenosella Walker in China under different climate scenarios based on the MaxEnt model
Authors: Wang Zhiling , Zhuo Zhihang , Peng Yaqin , Xu Danping 
Published: October 2024

AbstractAs global warming increases with the frequency of extreme weather, the distribution of species is inevitably affected. Among them, highly damaging invasive species are of particular concern. Being able to effectively predict the geographic distribution of invasive species and future distribution trends is a key entry point for their control. Opisina arenosella Walker is an invasive species, and its ability to live on the backs of foliage and generate canals to hide adds to the difficulty of control. In this paper, the current and future distributions of O. arenosella under three typical emission scenarios in 2050 and 2090 are projected based on the MaxEnt model combining 19 bioclimatic variables. Filter through the variables to find the four key environment variables: BIO 1, BIO 6, BIO 11 and BIO 4. The results show that O. arenosella is distributed only in the eight provinces of Tibet, Yunnan, Fujian, Guangxi, Taiwan, Guangdong, Hong Kong and Hainan in the southeastern region. Its high suitability area is concentrated in Taiwan and Hainan. In the long run, highly suitable areas will continue to increase in size, while moderately suitable areas and poorly suitable areas will decrease to varying degrees. This paper aims to provide theoretical references for the control of O. arenosella.
Potential utility of RSAD2 transcript and protein in early detection of pregnancy in buffaloes
Authors: Singh Samridhi , Choudhary Ratan Kumar 
Published: October 2024

AbstractThis study investigates a novel early pregnancy marker in water buffaloes, focusing on RSAD2 mRNA expression, known to be upregulated by interferon-tau (IFNT) during pregnancy. While RSAD2 is primarily recognized for its antiviral effect, we hypothesized its role as a conceptus-induced component in regulating pregnancy in buffaloes. Given its differential expression compared to other IFNT-induced genes in cows, RSAD2 may serve as a biomarker for early pregnancy detection in buffaloes. RNA, cDNA, and plasma samples were obtained from archived samples collected before insemination (d0) and at d20, d25 and d40 after insemination. Twelve RNA samples, having optimal optical density and concentration, from six pregnant and six non-pregnant buffaloes were selected. The cDNA was analyzed to measure the abundance of RSAD2 mRNA using real-time quantitative PCR (RT-qPCR) and plasma for protein expression analysis using Western blot. The RT-qPCR analysis showed a transcript of RSAD2 increased significantly by 7-fold and 6-fold on d20 and d25, compared to both d0 and d40 in the pregnant group only. At d20, the sensitivity of RSAD2 was 100% and the specificity was 83.3%, and at d25-d both the sensitivity and specificity was 100%, indicating low incidences of misdiagnosing early pregnancy in buffaloes. In the non-pregnant group, RSAD2 expression remained low and did not change after insemination. Western blot analysis revealed an immunoreactive RSAD2 protein band. Densitometry analysis of the RSAD2-specific protein band, based on gray mean value, showed significantly increased expression of RSAD2 at d25 compared to d0 in the pregnant group. In conclusion, these results indicated that RSAD2 expressions at both the mRNA and protein levels show promising potential for detecting pregnancy at d25 post-insemination.
Criminalising survivors of modern slavery: the United Kingdom’s National Referral Mechanism as a border-making process
Authors: Lumley-Sapanski Audrey , Rodriguez-Huerta Edgar , Young Matthew , Nicholson Andrea , Schwarz Katarina 
Published: October 2024

Abstract
The United Kingdom’s National Referral Mechanism (NRM) is a framework for identifying potential victims of modern slavery (slavery, servitude, forced labour or human trafficking) and ensuring that they receive adequate care. This research explores differences in referrals and outcomes of potential modern slavery victims within the NRM on the basis of individual attributes, geography and first responder. Findings are based on exploratory analysis of data on 55,000 cases released by the Home Office in spring 2022 plus data from four Freedom of Information requests. Findings confirm that there are significant differences in rates of positive outcomes between native and immigrant groups, with native populations more likely to receive positive conclusive grounds (CG) decisions. Our key contribution is in identification of the role of the first responder in negatively influencing outcomes for victims of particular forms of exploitation. We suggest the differences in outcomes may be explained by the dual role played by first responders within the immigration system in identifying victims and implementing immigration control measures. We situate this finding within a broader critical migration literature on polymorphous borders pointing to the NRM as one mechanism through which bodies are differentially excluded from territorial access and associated rights or benefits.
Legal challenges of attributing malicious cyber activities against space activities
Authors: Li Du 
Published: October 2024

AbstractMalicious cyber activities against space activities (MCASAs) add to the complexities of the legal attribution of malicious cyber activities violating international law. The ‘space’ implies the possibility of applying international space law considering the lex specialis derogat legi generali (more specific rules will prevail over more general rules) principle. However, neither the attribution rules of international space law nor of general international law could completely tackle this dilemma. This study categorizes MCASAs into three categories based on the role of the involved space activities and analyses the crux of legal attribution in each scenario. It proposes different coping approaches, including a four-pronged way, introducing a peculiarity test, and specifying substantive international obligations of the states responsible for space activities.
Atrial flow regulator in transposition of the great arteries, ventricular septal defect, and pulmonary stenosis: a case report
Authors: Bichali Saïd , Delarue Alexandre , Houeijeh Ali 
Published: October 2024

AbstractA 5-month-old girl with transposition of the great arteries, ventricular septal defect, and pulmonary stenosis underwent the implantation of a 6-mm M Atrial Flow Regulator (Occlutech) over an 8-French delivery sheath for significant cyanosis and progressive restriction of the atrial septal defect, without adverse event for 6 months. The Atrial Flow Regulator device could improve blood mixing as a bridge to surgery.
Enhancing Psychological Wellbeing Practitioner (PWP) practice for depression and anxiety in the context of personality difficulties: a pilot audit of CPD workshop feedback
Authors: Warbrick Laura A. , Lavelle Timothy , Dunn Barnaby D. 
Published: October 2024

Abstract
Psychological Wellbeing Practitioners (PWPs) are central to NHS Talking Therapies services for depression and anxiety (TTad; formerly ‘IAPT’). This workforce has been trained to deliver low-intensity treatments for mild to moderate depression and anxiety. In practice, PWPs routinely work with more complex clients, likely due to a combination of reasons. Over half of referrals experience concurrent personality difficulties, which are linked to poorer treatment outcomes, and PWPs describe feeling unskilled to work with these clients. This study aimed to develop and pilot a Continuing Professional Development workshop for PWPs about enhancing practice in the context of concurrent personality difficulties; and evaluate acceptability, feasibility and potential impacts on clinical skills and attitudes. This is an audit of routine feedback from a pilot of the workshop offered in a single TTad PWP workforce (n=139). The workshop was successfully developed and a series of five workshops were delivered to 74% of the PWP workforce. Feedback was overwhelmingly positive, and a majority of PWPs reported improved confidence in key skills covered during the workshop, and a positive attitude towards working with clients with personality difficulties after the workshop. PWPs described enhanced capability, opportunity and motivation to undertake work with this client group following the workshop. The workshop showed potential to improve PWP confidence and skill to support TTad clients in the context of personality difficulties, although it is not yet known if this translates to better treatment outcomes for clients. Implications for practice and future research are discussed.

Key learning aims

(1)
Understand the feasibility of gathering feedback and outcome data of a Continuing Professional Development (CPD) workshop delivered in routine practice for PWPs.

(2)
Understand PWP perspectives on attending a CPD workshop to support tailoring PWP treatments for depression and anxiety in the context of personality difficulties.

(3)
Reflect on potential opportunity to enhance PWP treatments in the context of personality difficulties via brief training workshops.

(4)
Consider how COM-B can be used to explore barriers and enablers to PWPs implementing new learning to their practice.
Twin Data Support a Sensitive Period for Singing Ability
Authors: Yeom Daniel , Haslam Nick , Tan Yi Ting , McPherson Gary E. , Wilson Sarah J. 
Published: October 2024

AbstractAs with many other musical traits, the social environment is a key influence on the development of singing ability. While the familial singing environment is likely to be formative, its role relative to other environmental influences such as training is unclear. We used structural equation modeling to test relationships among demographic characteristics, familial environmental variables (early and current singing with family), vocal training, and singing ability in a large, previously documented sample of Australian twins (N = 1163). Notably, early singing with family, and to a lesser extent vocal training, predicted singing ability, whereas current singing with family did not. Early familial singing also mediated the relationship between sex and singing ability, with men who sang less with family during childhood showing poorer ability. Bivariate twin models between early familial singing and singing ability showed the phenotypic correlation was largely explained by shared environmental influences. This raises the possibility of a sensitive period for singing ability, with sociocultural expectations around singing potentially differentiating the developmental trajectories of this skill for men and women.
Additive engineering for Sb2S3 indoor photovoltaics with efficiency exceeding 17%
Authors: Chen Xiao , Shu Xiaoxuan , Zhou Jiacheng , Wan Lei , Xiao Peng , Fu Yuchen , Ye Junzhi , Huang Yi-Teng , Yan Bin , Xue Dingjiang , Chen Tao , Chen Jiejie , Hoye Robert L. Z. , Zhou Ru 
Published: October 2024

AbstractIndoor photovoltaics (IPVs) have attracted increasing attention for sustainably powering Internet of Things (IoT) electronics. Sb2S3 is a promising IPV candidate material with a bandgap of ~1.75 eV, which is near the optimal value for indoor energy harvesting. However, the performance of Sb2S3 solar cells is limited by nonradiative recombination, which is dependent on the quality of the absorber films. Additive engineering is an effective strategy to fine tune the properties of solution-processed films. This work shows that the addition of monoethanolamine (MEA) into the precursor solution allows the nucleation and growth of Sb2S3 films to be controlled, enabling the deposition of high-quality Sb2S3 absorbers with reduced grain boundary density, optimized band positions, and increased carrier concentration. Complemented with computations, it is revealed that the incorporation of MEA leads to a more efficient and energetically favorable deposition for enhanced heterogeneous nucleation on the substrate, which increases the grain size and accelerates the deposition rate of Sb2S3 films. Due to suppressed carrier recombination and improved charge-carrier transport in Sb2S3 absorber films, the MEA-modulated Sb2S3 solar cell yields a power conversion efficiency (PCE) of 7.22% under AM1.5 G illumination, and an IPV PCE of 17.55% under 1000 lux white light emitting diode (WLED) illumination, which is the highest yet reported for Sb2S3 IPVs. Furthermore, we construct high performance large-area Sb2S3 IPV minimodules to power IoT wireless sensors, and realize the long-term continuous recording of environmental parameters under WLED illumination in an office. This work highlights the great prospect of Sb2S3 photovoltaics for indoor energy harvesting.
Clinical and economic outcomes of a pharmacogenomics-enriched comprehensive medication management program in a self-insured employee population
Authors: Fragala Maren S. , Keogh Murray , Goldberg Steven E. , Lorenz Raymond A. , Shaman Jeffrey A. 
Published: October 2024

AbstractClinical and economic outcomes from a pharmacogenomics-enriched comprehensive medication management program were evaluated over 26 months in a self-insured U.S. employee population (n = 452 participants; n = 1500 controls) using propensity matched pre-post design with adjusted negative binomial and linear regression models. After adjusting for baseline covariates, program participation was associated with 39% fewer inpatient (p = 0.05) and 39% fewer emergency department (p = 0.002) visits, and with 21% more outpatient visits (p < 0.001) in the follow-up period compared to the control group. Results show pharmacogenomics-enriched comprehensive medication management can favorably impact healthcare utilization in a self-insured employer population by reducing emergency department and inpatient visits and can offer the potential for cost savings. Self-insured employers may consider implementing pharmacogenomics-enriched comprehensive medication management to improve the healthcare of their employees.