bluuebunny/crossref_metadata_2025_split huggingface dataset:
Response to inhaled loxapine in patients with schizophrenia or bipolar I disorder: PANSS-EC responder analyses
Authors: Zeller Scott , Zun Leslie , Cassella James V. , Spyker Daniel A. , Yeung Paul P. 
Published: November 2017

BackgroundEfficacy of inhaled loxapine 5 or 10 mg in treating agitation was shown using the Positive and Negative Syndrome Scale – Excited Component (PANSS-EC) in two Phase III randomised, double-blind, placebo-controlled trials in 344 agitated patients with schizophrenia and 314 patients with bipolar I disorder (Clinicaltrials.gov: NCT00628589, NCT00721955).AimsTo examine the five individual items comprising the PANSS-EC and the percentage of patients achieving a clinical response (reduction of ≥40%) in PANSS-EC (Response-40) for these two studies.MethodResponse-40 was examined at the primary end-point (2 h) and over time.ResultsResponse-40 and each PANSS-EC item score were statistically significant v. placebo at 2 h and at each assessment time point for both doses.ConclusionsInhaled loxapine produced rapid improvement in agitated patients with schizophrenia or bipolar I disorder, achieving Response-40 at the first assessment (10 min post dose). These results highlight the effectiveness of loxapine across all components of agitation as measured by the PANSS-EC.
The effect of different training programs on throwing accuracy of elite female handball players
Authors: Eler Nebahat , Eler Serdar 
Published: November 2017

The aim of this study is to examine the acute effect of different training programs applied to elite female handball players on throwing accuracy. 14 elite female players were participated in the study. The mean age of the participating players was 28.64 ± 9.88 (years), the mean height length was 176.50 ± 4.86 (cm), the mean body weight was 68.07 ± 2.12 (kg) and the mean sport age was 14.36 ± 4.89 (years). On different days, a technical training program, maximal strength training program, strength endurance training program and speed power training program have been implemented to the participating players in the research. Before and after training, the players throwing the ball from their area to the specific points of goal and the percentage of accuracy was determined. As a result; there was a significant difference between before and after maximal strength training the mean values of throwing accuracy (p<0,05) but there was no significant difference before and after other training programs (p> 0,05). This result indicates that acute maximal strength training has a negative effect on throwing accuracy.
A comparison of postoperative morphometric and hemodynamic changes between saphenous vein and left internal mammary artery grafts
Authors: Fan Tingting , Feng Yundi , Feng Feng , Yin Zhongjie , Luo Dayou , Lu Yuan , Xu Yingjin , Tan Wenchang , Huo Yunlong 
Published: November 2017

AbstractThere is higher long‐term failure of the saphenous vein graft (SVG) compared with the left internal mammary artery (LIMA) graft, which is affected by the hemodynamic environment. A comprehensive analysis of postoperative structure‐function changes is important to study the atherogenesis in the SVG. A comparison of morphometric and hemodynamic parameters was carried out between LIMA grafts and SVGs and between different time points postoperatively. Various parameters were obtained from the image reconstruction and flow simulation in patients, who underwent CT exams for ~1 year, 5 and 10 years after revascularization. Morphometric data showed a decrease in lumen size in the entire SVG and anastomosis of different patients in a sequence of ~1 year, 5 and 10 years postoperatively despite negligible changes of LIMA size. Computational results indicated the fourfold increased surface area ratio (SAR) of low time‐averaged wall shear stress (TAWSS) in the SVG and anastomosis at postoperative 10 years than that at postoperative ~1 year. The SAR of high TAWSS gradient (TAWSSG) at the distal anastomosis between SVG and coronary arteries was significantly higher (14 ± 9% vs. 6 ± 8%) than that in the LIMA group at postoperative ~1 year. There were strong correlations between morphometric and hemodynamic parameters in the SVG and distal anastomosis at various time points postoperatively, which showed deterioration relevant to persistent diffuse diseases at postoperative ~10 years.
MiR‐335 overexpression impairs insulin secretion through defective priming of insulin vesicles
Authors: Salunkhe Vishal A. , Ofori Jones K. , Gandasi Nikhil R. , Salö Sofia A. , Hansson Sofia , Andersson Markus E. , Wendt Anna , Barg Sebastian , Esguerra Jonathan L. S. , Eliasson Lena 
Published: November 2017

AbstractMicroRNAs contribute to the maintenance of optimal cellular functions by fine‐tuning protein expression levels. In the pancreatic β‐cells, imbalances in the exocytotic machinery components lead to impaired insulin secretion and type 2 diabetes (T2D). We hypothesize that dysregulated miRNA expression exacerbates β‐cell dysfunction, and have earlier shown that islets from the diabetic GK‐rat model have increased expression of miRNAs, including miR‐335‐5p (miR‐335). Here, we aim to determine the specific role of miR‐335 during development of T2D, and the influence of this miRNA on glucose‐stimulated insulin secretion and Ca2+‐dependent exocytosis. We found that the expression of miR‐335 negatively correlated with secretion index in human islets of individuals with prediabetes. Overexpression of miR‐335 in human EndoC‐βH1 and in rat INS‐1 832/13 cells (OE335) resulted in decreased glucose‐stimulated insulin secretion, and OE335 cells showed concomitant reduction in three exocytotic proteins: SNAP25, Syntaxin‐binding protein 1 (STXBP1), and synaptotagmin 11 (SYT11). Single‐cell capacitance measurements, complemented with TIRF microscopy of the granule marker NPY‐mEGFP demonstrated a significant reduction in exocytosis in OE335 cells. The reduction was not associated with defective docking or decreased Ca2+ current. More likely, it is a direct consequence of impaired priming of already docked granules. Earlier reports have proposed reduced granular priming as the cause of reduced first‐phase insulin secretion during prediabetes. Here, we show a specific role of miR‐335 in regulating insulin secretion during this transition period. Moreover, we can conclude that miR‐335 has the capacity to modulate insulin secretion and Ca2+‐dependent exocytosis through effects on granular priming.
Performance Motivation of Elite Athletes, Recreational Athletes and Non-Athletes
Authors: Šmela Pavel , Pačesová Petra , Kraček Stanislav , Hájovský Dan 
Published: November 2017

AbstractThe aim of the paper is to widen knowledge about motivation of elite, recreational athletes and non-athletes. Participants from the elite athletes group (n = 35, 16.7 ± .70 years old) were football players of the Slovak national team. Recreational athletes (n = 31, 16.8 ± .80 years old) and non-athletes (n = 29, 15.7 ± .60 years old) are visiting Grammar School in Zvolen. D-M-V standardized questionnaire was used to determine performance motivation. The Kolmogorov-Smirnov's test disconfirmed the null hypothesis on the normality of data. We used the non-parametric Kruskal-Wallis and Mann-Whitney U tests to determine the statistical significance of the differences. The results showed that there were significant (p .0.01) differences with large effect size (η2≥ .14) in all the three (the performance motives scale, the anxiety inhibiting performance scale and the anxiety supporting performance scale) dimensions among the research groups. The motivation of elite athletes is significantly higher (p = .048; r = .25) compared to the recreational athletes. Also, compared to the non-athletes, the level of performance motivation is significantly higher (p = .002; r = .51) in the elite athletes. Based on the results of the study we can formulate the statement that the level of performance motivation is contingent on the level of sport activity.
Teaching Games for Understanding: A Comprehensive Approach to Promote Student’s Motivation in Physical Education
Authors: Hortigüela Alcalá David , Hernando Garijo Alejandra 
Published: November 2017

Abstract
It seems important to consider students’ attitudes towards physical education (PE), and the way they learn sports. The present study examines students’ perceptions of motivation and achievement in PE after experiencing three consecutive sport units. Two hundred and thirty seven students from the 1st, 2nd, 3rd, and 4th grade in a high school in Burgos (Spain) and two teachers agreed to participate. They were divided into two groups in order to compare two instructional approaches. The experimental group (A), 128 students, experienced Teaching Games for Understanding (TGfU), while the control group (B), 109 students, experienced a technical-traditional approach. Each group was taught by a different teacher. The study followed a mixed-method research design with quantitative (questionnaire) and qualitative (interview) data. Results revealed that group A showed greater motivation and achievement in PE than group B. Significant differences were found in achievement. Participants with better academic results in group A were more positive in sport participation. Meanwhile, students who practiced more extracurricular sports in group B were more actively involved in sport. Teachers disagreed greatly on the way sport should be taught in PE.
The Cognitive and Motivation Intervention Program in Youth Female Volleyball Players
Authors: Claver Fernando , Jiménez Ruth , Gil-Arias Alexander , Moreno Alberto , Moreno M. Perla 
Published: November 2017

Abstract
This study, grounded in Self-Determination Theory (Deci and Ryan, 1985, 2002) was aimed to determine the influence of a cognitive-motivational intervention program, to improve the basic psychological need satisfaction of autonomy and competence, autonomous motivation, procedural knowledge, perceived performance and sport commitment, in youth volleyball players. Participants included 34 Under-19 female volleyball players. A quasi-experimental design was carried out with an experimental group (n = 16; M = 17.45; SD = .45) and a control group (n = 18; M = 16.64; SD = .70). The experimental group followed a multidimensional intervention program comprised of 24 sessions held over three months (two training sessions per week). It was based on two strategies: giving athletes the possibility of choice in specific training tasks (proposing training situations with several action alternatives) and questioning (cognitively involving players through tactical questions). A repeated-measures MANOVA 2 (group: experimental and control) x 2 (time: pre-test and post-test) was used to analyse the effect of Group x Time interaction. The results of the inter-group analysis showed significant differences in the post-test measurement between the experimental group and the control group (in favour of the experimental group) in the variables: basic psychological need satisfaction of autonomy and competence, autonomous motivation, procedural knowledge, perceived performance and sport commitment. Given the relevance of the cognitive-motivational processes, not only for performance but also for sport commitment, this intervention has important implications for sport coaching.
Motivational Antecedents of Well-Being and Health Related Behaviors in Adolescents
Authors: Balaguer Isabel , Duda Joan L , Castillo Isabel 
Published: November 2017

AbstractGrounded in the Achievement Goal Theory framework of motivation and optimal functioning, there were two objectives of this study: (a) to test a model hypothesizing links between personal theories of school achievement, indices of the quality of academic engagement, wellbeing, and health-related behaviors, and (b) to explore whether the hypothesized model was invariant across gender groups. A multisection questionnaire pack tapping the targeted variables was administered to 967 teenagers (475 boys and 492 girls) aged between 11 to 16 years old. Structural equation modeling analysis revealed that Task theory of achievement predicted positively satisfaction in school and negatively boredom in school. An Ego theory of achievement was linked to higher levels of boredom in school. Satisfaction in school corresponded to higher life satisfaction, while boredom was negatively related. Higher life satisfaction was associated with lower tobacco, alcohol and marijuana consumption, more healthy food intake and greater levels of physical activity. The results revealed partial invariance of the model by gender. The quality of adolescents’ involvement in the classroom holds important implications for adolescent’s well-being and their health related behaviors. Interventions on the creation of a task-involving motivational climate in the school are proposed to promote healthy lifestyles among young people.
Coherent multicore methodology and tooling
Authors: Reinkemeier Philipp , Ittershagen Philipp , Dieudonne Laurent , Diebold Philipp 
Published: November 2017

Abstract
In the mobility domains functions are often realized by software running on Electronic Control Units (ECU)s, which are
interconnected in a network of ECU. Nowadays there is a trend to move to ECUs with multicore processors which imposes
a major challenge: An increasing degree of parallelism. This additional parallelism when migrating existing software that
has been developed for singlecore systems, to a multicore system, has to be used in an efficient way. Furthermore, an
increase in parallelism can cause concurrent executions of software functions, which are not possible when being executed
on a singlecore ECU. This makes reasoning about the software behaviour much more difficult and also poses problems during
certification activities, when sufficient independence between functions needs to be ensured. Therefore tool support is
absolutely necessary to address the challenges. In this article we describe methods and tools that have been developed
and/or extended during the ARAMiS project to address particular challenges arising during the development of multicore
systems. In general these challenges result from the increase in parallelism available in multicore architectures.
Multicore system architecture aspects and deployment
Authors: Kuntz Stefan , Dieudonne Laurent 
Published: November 2017

Abstract
The crucial foundation in developing embedded safety-critical real-time systems based on multicore based platforms is the
capability to combined different methodologies and approaches with a sound formal description of the system
architecture. With such a system of methodologies and system architectures it is possible to develop a system satisfying
all requirements and even being able to optimize the overall system towards domain specific goals. This article discusses
activities in ARAMiS, which have been performed on system architecture level, including improvements of modeling existing
architectures and design techniques concerning reliability, independence, segregation and determinism for deployment
strategies.
Chinese Universities and the Market for Ideas
Authors: Wang Ning 
Published: November 2017

Abstract
This paper examines China’s ongoing revolution in higher education. On the bright side, Chinese higher education has enjoyed four decades of remarkable expansion, as measured by college enrollment, post-graduate training, research capacities and various global rankings. In 2007, China’s higher education has become the largest in the world in terms of student enrollment. Yet, after decades of economic liberalization and marketization, Chinese higher education is one of the few areas that remain monopolized by the state. Despite extraordinary progresses Chinese universities have recently made, they have been repeatedly criticized by many insiders (university presidents, college deans, professors, as well as students and their parents) for the lack of academic freedom. It remains to be seen whether China’s universities can transform themselves from an institution of higher education to a home of liberal learning and innovation.
A magyarországi egyetemtörténet-írás eredményei és feladatai
Authors: Szögi László 
Published: November 2017

In the following paper we display the development of writings about universities history in the last 25 years. It is important to underline that we use the name of Hungary as a historical definition. In this case it means the whole territory of the Carpathian Basin, because the current boarders were created in 1920. Since the Hungarian universities were founded late the possibility of attendance at foreign universities represented great importance. Nowadays, we possess a database with more than 100.000 records about Hungarian students who attended foreign universities before 1918. Many source editions, analyses and monographs were published in this topic. The purpose of the following article is to summarize the most notable volumes.
Photo: pexels.com
Balance and Functional Outcomes for Older Community-Dwelling Adults Who Practice Tai Chi and Those Who Do Not: A Comparative Study
Authors: Bubela Deborah , Sacharko Laddie , Chan Judy , Brady Maegen 
Published: November 2017

Background and Purpose:
A growing body of literature substantiates that Tai Chi is a form of exercise that may help older adults increase strength, improve balance, lower fall rates, and experience less fear of falling. Few studies, however, offer controlled experimental design and simultaneously investigate multiple factors known to contribute to fall risk. The purpose of this study was to compare performance on measures relating to fall risk (strength, balance, functional mobility, and fear of falling) in older community-dwelling adults who participated in a community-based Tai Chi program with a control group of their peers who had no Tai Chi training over the same time period.

Methods:
A quasi-experimental comparative pre- and posttest design was used to compare an experimental group of 16 community-dwelling older adults, mean (SD) age = 80.4 (6.8) years, participating in a 16-week Tai Chi training program with a group of 13 adults, mean (SD) age = 71.2 (6.1) years, who had no Tai Chi experience in the areas of knee extension strength (measured by handheld dynamometry), functional strength (by five-time sit to stand), mobility (by Timed Up and Go [TUG] test and Fifty-Foot Walk Test), balance (by Functional Reach and Berg Balance Scale), and fear of falling (by Activity-specific Balance Confidence scale). Within-group and between-groups comparisons were made using 2×2 mixed analysis of variance.

Results:
Tai Chi participants improved in nearly all measures, whereas controls did not. Tai Chi participants experienced significant improvement in the TUG test during the training period (P = .003), with significant difference when compared with controls (P = .049) and moderate effect size and observed power (ηp
2 = 0.165; observed power = 0.512). Significant knee extension strength improvement occurred (P = .042) with moderate effect size and observed power (ηp
2 = 0.183; observed power = 0.543). While the total balance confidence scale score did not change significantly, responses on many individual items did reach a level of significant change for persons participating in the Tai Chi training.

Conclusion:
Older adults' participation in a community-based Tai Chi program may lead to improvement in strength, mobility, and confidence in performing functional tasks. Incorporation of elements of Tai Chi into therapy programs for older adults at risk for fall and referral to community-based Tai Chi programs may be viable options in the continuum of health-related care for older adults.
A Framework of Applying Ordering Coefficient Based on the Information Energy to Identify the Causal Relationships among Critical Factors from Raw Data
Authors: Shieh J.-I. , Wu H.-H. 
Published: November 2017

Abstract
Causal relationships among critical factors have been extensively studied in recent years. The most commonly seen methods based on the questionnaire to construct the causal relationships are decision-making trial and evaluation laboratory (DEMATEL) method and semantic structure analysis (SSA) method. However, both methods have their own limitations. In contrast, an ordering coefficient based on information energy has a solid theoretical background to study causal relationships among critical factors. In order to identify the threshold value to establish causal relationships from the raw data, a bootstrapping Monte Carlo simulation for an ordering coefficient based on information energy was conducted. Finally, a brief case study was presented and discussed with the use of an ordering coefficient based on information energy and a bootstrapping Monte Carlo simulation when the raw data are available to construct the causal relationships among the criteria.
Fitness Costs and Variation in Transmission Distortion Associated with the Abnormal Chromosome 10 Meiotic Drive System in Maize
Authors: Higgins David M , Lowry Elizabeth G , Kanizay Lisa B , Becraft Philip W , Hall David W , Dawe R Kelly 
Published: November 2017

AbstractThe maize abnormal chromosome 10 (Ab10) meiotic drive system causes its own preferential transmission through females, yet it is found at low frequencies...Meiotic drive describes a process whereby selfish genetic elements are transmitted at levels greater than Mendelian expectations. Maize abnormal chromosome 10 (Ab10) encodes a meiotic drive system that exhibits strong preferential segregation through female gametes. We performed transmission assays on nine Ab10 chromosomes from landraces and teosinte lines and found a transmission advantage of 62–79% in heterozygotes. Despite this transmission advantage, Ab10 is present at low frequencies in natural populations, suggesting that it carries large negative fitness consequences. We measured pollen transmission, the percentage of live pollen, seed production, and seed size to estimate several of the possible fitness effects of Ab10. We found no evidence that Ab10 affects pollen transmission, i.e., Ab10 and N10 pollen are transmitted equally from heterozygous fathers. However, at the diploid (sporophyte) level, both heterozygous and homozygous Ab10-I-MMR individuals show decreased pollen viability, decreased seed set, and decreased seed weight. The observed fitness costs can nearly but not entirely account for the observed frequencies of Ab10. Sequence analysis shows a surprising amount of molecular variation among Ab10 haplotypes, suggesting that there may be other phenotypic variables that contribute to the low but stable equilibrium frequencies.