bluuebunny/crossref_metadata_2025_split huggingface dataset:
School performance for children with cleft lip and palate: a population‐based study
Authors: Bell J. C. , Raynes‐Greenow C. , Turner R. , Bower C. , Dodson A. , Nicholls W. , Nassar N. 
Published: August 2016

AbstractBackgroundEducational attainment is important in shaping young people's life prospects. To investigate whether being born with orofacial cleft (OFC) affects school performance, we compared school test results between children born with and without OFC.MethodsUsing record‐linked datasets, we conducted a population‐based cohort study of children liveborn in Western Australia 1980–2010 with a diagnosis of OFC on the Register of Developmental Anomalies, and a random sample of 6603 children born without OFC. We compared odds ratios for meeting national minimum standards in five domains (reading, numeracy, writing, spelling, grammar and punctuation), and adjusted OR (aOR) for children with cleft lip only (CLO), cleft lip and palate (CL + P) and cleft palate only (CPO) for each domain.ResultsResults from two testing programs (WALNA and NAPLAN) were available for 3238 (89%) children expected to participate. Most met the national minimum standards. Compared with children without OFC, children with CPO were less likely to meet minimum standards for NAPLAN reading (aOR 0.57 [95%CI 0.34, 0.96]) grammar and punctuation (aOR 0.49 [95%CI 0.32, 0.76]), WALNA writing (aOR 0.66 [95%CI 0.47, 0.92]), and WALNA and NAPLAN numeracy (aOR 0.64 [95%CI 0.43, 0.95] and aOR 0.47 [95%CI 0.28, 0.82]), respectively. Children with CL + P had significantly lower odds for reaching the spelling standard in NAPLAN tests (aOR 0.52 [95%CI 0.29, 0.94]). Children with CLO had similar odds for reaching all minimum standards.ConclusionChildren born with OFC, particularly children with CPO, should be monitored to identify learning difficulties early, to enable intervention to maximize school attainment.
Fundamental literature and hot topics on rural left‐behind children in China: a bibliometric analysis
Authors: Wang L. , Wei Y. , Ma Y. , Wang T. 
Published: August 2016

AbstractBackgroundRecently, the literature on rural left‐behind children in China has rapidly grown. However, no comprehensive review of the status of knowledge on the issue exists.MethodsA co‐cited network map of 327 studies (covering 1998 through 2014) drawn from the Chinese Social Studies Citation Index database was analysed.ResultsUsing visualization software, the results identified three fundamental studies on the issue and four hot topics: interventions, deviant behaviours, mental health and family childrearing strategies. The analysis found that knowledge on this topic could be furthered by (1) focusing on protective factors and (2) integrating disciplines by standardizing concepts and measures.ConclusionsThese study's results are an important reference for the development of theories, practices and policies regarding rural left‐behind children in China.
The effect of experimental osteoporosis on bone regeneration: Part 1, histology findings
Authors: Calciolari Elena , Mardas Nikos , Dereka Xanthippi , Kostomitsopoulos Nikolaos , Petrie Aviva , Donos Nikolaos 
Published: August 2016

AbstractObjectivesTo histologically define the healing events occurring in calvarial critical size defects (CSDs) following treatment with a collagen barrier for guided bone regeneration (GBR) and a particulate graft in healthy and osteoporotic conditions.Material and MethodsThirty‐six 10‐month‐old, female, Wistar rats were used in this study. Half of them were ovariectomized (OVX) and fed with a low‐calcium diet to induce an osteoporotic‐like status. In each animal of both groups, two 5‐mm CSDs were created, one in the centre of each parietal bone, and they were treated with a deproteinized bovine bone mineral (DBBM) particulate graft and a bi‐layer collagen membrane. Six OVX and six healthy control rats were randomly euthanized at 7, 14 and 30 days. One defect per animal was randomly processed for decalcified histology. Three central sections were used for qualitative histology and histomorphometric analysis.ResultsNo significant difference in terms of percentage of newly formed bone was detected between the two groups at the different healing periods. However, a trend towards less bone formation and of poorer quality, expressed as reduced bone maturation, was detected in the OVX animals at 30 days.DiscussionAccording to this study, GBR with a collagen barrier and a DBBM graft can be successfully obtained also in osteoporotic‐like conditions. Future studies considering longer healing periods and controlling for the confounding factors arising from the use of a particulate graft are needed to confirm these data.
Ten‐year hard and soft tissue results of a pilot double‐blinded randomized controlled trial on immediately loaded post‐extractive implants using platform‐switching concept
Authors: Canullo Luigi , Caneva Martina , Tallarico Marco 
Published: August 2016

AbstractAimTo evaluate the 10‐year post‐loading radiological and esthetic outcomes of implants inserted in post‐extraction sites and restored with or without platform‐switching protocol.Material and methodsTwenty‐two patients were scheduled for maxillary post‐extractive implant, using a 13 mm in length and 5.5 mm in diameter implant (Global, Sweden & Martina, Padua, Italy). They randomly received definitive restorations using platform‐switching concept (abutment 3.8 mm in diameter: test group) or standard restoration (abutment 5.5 mm in diameter: control group). Outcome measures were survival rates of implants and prostheses, peri‐implant marginal bone loss and periodontal indices 10 years after prosthetic loading. Moreover, esthetic parameters including soft tissue buccal peri‐implant mucosal levels (REC) and mesial and distal papilla height (PH) were taken at definitive restoration, 2 and 10 years thereafter.ResultsNineteen implants were analyzed after 10 years of follow‐up. No implants nor prostheses failed. The postoperative radiographs demonstrated an overall mean bone loss of 0.18 ± 0.14 mm in the test group and of 0.80 ± 0.40 mm in the control group (P = 0.00108). Test group showed 0.23 ± 0.51 mm of REC gain and PH was of 0.21 ± 0.33 mm on average. On the other side, the control group presented a REC = −0.59 ± 0.80 mm with PH = −1.12 ± 0.55 mm, demonstrating a slight continuous soft tissue shrinkage during the entire follow‐up. The mean values were statistically significant different between test and control group for both REC gain (P = 0.01174) and PH (P = 0.0009).ConclusionsWith the limitations of this study, immediate single implant restorations rehabilitated with platform‐switching protocol may provide peri‐implant alveolar bone‐level stability and avoid continuous soft tissue shrinkage after 10 years of prosthetic loading compared to a platform‐matching restoration. Further studies involving larger sample sizes are required to confirm these preliminary results.
Metformin use and risk of lactic acidosis in people with diabetes with and without renal impairment: a cohort study in Denmark and the UK
Authors: Li L. , Jick S. , Gopalakrishnan C. , Heide‐Jørgensen U. , Nørrelund H. , Sørensen H. T. , Christiansen C. F. , Ehrenstein V. 
Published: August 2016

AbstractAimsTo assess risk of lactic acidosis among metformin users compared with other glucose‐lowering agent users, according to renal function.MethodsUsing routine registries and databases, we conducted a cohort study. Of 43 580 metformin and 37 788 other glucose‐lowering agent users in northern Denmark and 102 688 metformin and 28 788 other glucose‐lowering agent users in the UK during 2001–2011, we identified lactic acidosis using diagnostic codes. We calculated the incidence rates of lactic acidosis in metformin and other glucose‐lowering agent users overall and according to baseline estimated GFR (eGFR) levels.ResultsIn Denmark, the incidence rates of lactic acidosis were 11.6 (95% CI 7.0–18.1) and 1.8 (95% CI 0.4–5.4) per 100 000 person‐years of metformin use and of other glucose‐lowering agent use, respectively. In the UK, the corresponding lactic acidosis incidence rates were 6.8 (95% CI 4.6–9.6) and 1.0 (95% CI 0.01–5.7) per 100 000 person‐years of metformin use and of other glucose‐lowering agent use. The incidence rates increased with decreasing baseline eGFR in both countries. Of the metformin‐exposed people with lactic acidosis, 37% in Denmark and 34% in the UK experienced a decline in renal function in the year before the diagnosis.ConclusionsRisk of lactic acidosis was higher in metformin users than in other glucose‐lowering agent users, and increased with decreasing eGFR, although this could be attributable to surveillance bias; however, diagnosed lactic acidosis was rare and can occur regardless of renal function.
Excessive blood pressure increase with exercise and risk of all‐cause mortality and cardiac events
Authors: Bouzas‐Mosquera María C. , Bouzas‐Mosquera Alberto , Peteiro Jesús 
Published: August 2016

AbstractBackgroundThe association of an excessive blood pressure increase with exercise (EBPIE) on cardiovascular outcomes remains controversial. We sought to assess its impact on the risk of all‐cause mortality and major cardiac events in patients with known or suspected coronary artery disease (CAD) referred for stress testing.Materials and methodsExercise echocardiography was performed in 10 047 patients with known or suspected CAD. An EBPIE was defined as an increase in systolic blood pressure with exercise ≥ 80 mmHg. The endpoints were all‐cause mortality and major cardiac events (MACE), including cardiac death or nonfatal myocardial infarction (MI).ResultsOverall, 573 patients exhibited an EBPIE during the tests. Over a mean follow‐up of 4·8 years, there were 1950 deaths (including 725 cardiac deaths), 1477 MI and 1900 MACE. The cumulative 10‐year rates of all‐cause mortality, cardiac death, nonfatal MI and MACE were 32·9%, 13·1%, 26·9% and 33% in patients who did not develop an EBPIE vs. 18·9%, 4·7%, 17·5% and 20·7% in those experiencing an EBPIE, respectively (P < 0·001 for all comparisons). In Cox regression analyses, an EBPIE remained predictive of all‐cause mortality (hazard ratio [HR] 0·73, 95% confidence interval [CI] 0·59–0·91, P = 0·004), cardiac death (HR 0·67, 95% CI 0·46–0·98, P = 0·04), MI (HR 0·67, 95% CI 0·52–0·86, P = 0·002) and MACE (HR 0·69, 95% CI 0·56–0·86, P = 0·001).ConclusionsAn EBPIE was associated with a significantly lower risk of mortality and MACE in patients with known or suspected CAD referred for stress testing.
Interictal epileptiform discharges have an independent association with cognitive impairment in children with lesional epilepsy
Authors: Glennon Jennifer M. , Weiss‐Croft Louise , Harrison Sue , Cross J. Helen , Boyd Stewart G. , Baldeweg Torsten 
Published: August 2016

SummaryObjectivesThe relative contribution of interictal epileptiform discharges (IEDs) to cognitive dysfunction in comparison with the underlying brain pathology is not yet understood in children with lesional focal epilepsy.MethodsThe current study investigated the association of IEDs with intellectual functioning in 103 children with medication‐resistant focal epilepsy. Hierarchical multiple regression analyses were used to determine the independent contribution of IED features on intellectual functioning, after controlling for effects of lesional pathology, epilepsy duration, and medication. Exploratory analyses were conducted for language and memory scores as well as academic skills available in a subset of participants.ResultsThe results reveal that IEDs have a negative association with IQ with independent, additive effects documented for frequent and bilaterally distributed IEDs as well as discharge enhancement in sleep. Left‐lateralized IEDs had a prominent effect on verbal intelligence, in excess of the influence of left‐sided brain pathology. These effects extended to other cognitive functions, most prominently for sleep‐enhanced IEDs to be associated with deficits in expressive and receptive language, reading, spelling and numerical skills.SignificanceOverall, IED effects on cognition were of a magnitude similar to lesional influences or drug effects (topiramate use). This study demonstrates an association between IEDs and cognitive dysfunction, independent of the underlying focal brain pathology.
Programmed cell death‐1 blockade enhances response to stereotactic radiation in an orthotopic murine model of hepatocellular carcinoma
Authors: Friedman David , Baird Jason R. , Young Kristina H. , Cottam Benjamin , Crittenden Marka R. , Friedman Scott , Gough Michael J. , Newell Pippa 
Published: August 2016

AimSmall, solitary hepatocellular carcinoma is curable with stereotactic radiation or other methods of tumor ablation, however, regional and systemic tumor recurrence occurs in over 70% of patients. Here we describe the ability of immunoradiotherapy to induce an antitumor immune response and delay the growth of tumors in immunocompetent mice.MethodsA syngeneic hepatocellular carcinoma cell line (Hep‐55.1c) was injected directly into the livers of C57BL/6 mice using ultrasound guidance, then tumors were treated with stereotactic radiation using a Small Animal Radiation Research Platform with computed tomography guidance.ResultsDelivery of three doses of 250 μg anti‐programmed cell death protein‐1 (αPD‐1) antibody concurrently with 30 Gy stereotactic body radiation therapy in three fractions reduced the growth rate of tumors and improved survival (P < 0.05). Combined treatment was associated with increased CD8+ cytotoxic T cells in the tumor; depletion of CD8 T cells eliminated the efficacy of combined treatment. Combined treatment also induced expression of programmed cell death‐1 ligand expression on tumor‐infiltrating macrophages, and the tumors grew rapidly after αPD‐1 treatment was discontinued.ConclusionsTumor response to stereotactic radiation can be augmented by concurrent treatment with αPD‐1. The efficacy of this combination therapy was transient, however, and treatment induced markers of adaptive immune resistance. These data are promising, but also indicate that mechanisms of immune resistance will need to be durably overcome for this combination to generate lasting immunity to protect against tumor recurrence.
BSHI Guideline: HLA matching and donor selection for haematopoietic progenitor cell transplantation
Authors: Little A‐M. , Green A. , Harvey J. , Hemmatpour S. , Latham K. , Marsh S. G. E. , Poulton K. , Sage D. 
Published: August 2016

SummaryA review of the British Society for Histocompatibility and Immunogenetics (BSHI) “Guideline for selection and HLA matching of related, adult unrelated donors and umbilical cord units for haematopoietic progenitor cell transplantation” was undertaken by a BSHI appointed writing committee. Literature searches were performed, and the data extracted were presented as recommendations according to the GRADE nomenclature.
The contribution of the citrate pathway to oxidative stress in Down syndrome
Authors: Convertini Paolo , Menga Alessio , Andria Generoso , Scala Iris , Santarsiero Anna , Castiglione Morelli Maria A. , Iacobazzi Vito , Infantino Vittoria 
Published: August 2016

SummaryInflammatory conditions and oxidative stress have a crucial role in Down syndrome (DS). Emerging studies have also reported an altered lipid profile in the early stages of DS. Our previous works demonstrate that citrate pathway activation is required for oxygen radical production during inflammation. Here, we find up‐regulation of the citrate pathway and down‐regulation of carnitine/acylcarnitine carrier and carnitine palmitoyl‐transferase 1 genes in cells from children with DS. Interestingly, when the citrate pathway is inhibited, we observe a reduction in oxygen radicals as well as in lipid peroxidation levels. Our preliminary findings provide evidence for a citrate pathway dysregulation, which could be related to some phenotypic traits of people with DS.
Validation of an algorithm to predict reulceration in amputation patients with diabetes
Authors: Molines‐Barroso Raúl J , Lázaro‐Martínez José L , Álvaro‐Afonso Francisco J , Sanz‐Corbalán Irene , García‐Klepzig José L , Aragón‐Sánchez Javier 
Published: August 2016

AbstractThe aim of this article was to assess the ability to predict reulceration in people with diabetes and a history of minor amputation according to the formula proposed by Miller et al. A retrospective study was performed on 156 consecutive records of patients with a recent history of simple or multiple forefoot amputation. The sample was divided according to Miller's formula into patients at low risk of reulceration and those at high risk; those were further divided into two subgroups according to whether or not the first segment of the forefoot had been amputated. Forty‐eight (47·1%) individuals suffered forefoot reulceration, showing a median reulceration‐free survival time of 8 months [interquartile range (IR) 3·6–14·8]. Nephropathy (P = 0.005) and Miller's formula (P = 0.028) were risk factors for reulceration‐free survival time in the univariate analysis. The pattern relating to the first segment amputated [hazard ratio (HR) 2·853; P = 0·004; 95% confidence interval (CI) 1·391–5·849] and nephropathy (HR 2·468; P = 0.004; 95% CI 1.328–4.587) showed a significant hazard ratio in the multivariate Cox model. Participants with first segment amputation and one other amputation showed an association with the probability of reulceration in comparison with any other specific type of minor amputation.
Effects of Duration of Waterlogging at Different Growth Stages on Grain Growth of Summer Maize (Zea mays L.) Under Field Conditions
Authors: Ren B. , Zhang J. , Dong S. , Liu P. , Zhao B. 
Published: August 2016

AbstractA field experiment was performed to study the effects of waterlogging for different durations (3 and 6 days) on grain filling and endosperm cell proliferation of summer maize hybrids DengHai605 (DH605) and ZhengDan958 (ZD958) at the third leaf stage (V3), the sixth leaf stage (V6) and the 10th day after the tasselling stage (10VT). Results showed that waterlogging damages on grain filling and endosperm cell proliferation varied with growth stage and duration of waterlogging. The most significant effect of waterlogging was observed at V3, followed by V6 and 10VT. Endosperm cell content, average endosperm cell proliferation rate, grain weight and grain‐filling rate were reduced significantly with increasing waterlogging durations, with the most significant (P < 0.05) reduction in V3‐6 with a decrease of 37.1 %, 51.9 %, 13.6 % and 12.1 % for DH605, and 27.3 %, 51.1 %, 17.4 % and 14.3 % for ZD958, respectively. Waterlogging damages on grain filling and endosperm cell proliferation resulted in a significant reduction in grain yield. Waterlogging at V3 had the most yield reduction, followed by V6 and 10VT. Yield reduction after waterlogging for 6 days at different stage was about twice as much as that after waterlogging for 3 days. Clearly, the most significant inhibition of grain growth for waterlogging was observed at V3, followed by V6 and 10VT. The inhibition was enhanced significantly with increasing waterlogging durations. Endosperm cell number and grain weight was decreased by 8.3–24.1 % and 1.2–10.8 % after waterlogging for 3 days, while decreased by 12.9–32.2 % and 4.6–14.7 % after waterlogging for 6 days, compared to CK.
The use of gamification in education: a bibliometric and text mining analysis
Authors: Martí‐Parreño J. , Méndez‐Ibáñez E. , Alonso‐Arroyo A. 
Published: August 2016

AbstractThe use of games in education represents a promising tool to motivate and engage students in their learning process. Most of previous research on the topic has focused to develop theoretical frameworks or to conduct experiments as a means to analyse learning outcomes such as knowledge retention, problem‐solving skills gains or attitudes toward game‐based learning. Nevertheless, little research has focused on providing a comprehensive literature review, which will help researchers to better understand how this stream of research has evolved over the last years. In this study, we use a bibliometric, social network and text mining analysis in order to provide useful up‐to‐date information to picture the state of the art about current research and evolution of the topic. Analysis on a sample of 139 articles published in top journals over the last 5 years (2010–2014) allowed identifying relevant authors and institutions, key constructs and themes involved, and trends of knowledge development. Main findings suggest an increasing academic interest on the topic over the last 5 years and a wide variety of constructs that were clustered in four main themes that we named: (i) effectiveness, (ii) acceptance, (iii) engagement and (iv) social interactions. Future research lines are also addressed.Lay DescriptionWhat is currently known about the use of games in education:

Games can increase students' intrinsic motivation to learn.
Games support active learning.
Games facilitate scaffolded instruction based on each individual student's needs.
What this paper adds to this:

This study identifies the most relevant researchers in this research area.
This study identifies the most relevant institutions involved in this research area.
This study identifies the main topics and themes researched by researchers.
This study identifies the main methodological approach used by researchers.
Findings for practitioners:

Relevant researchers and institutions to collaborate with.
Topics and themes under research.
Methods used to research the use of games in education.
Periodontal conditions and incidence of new cardiovascular events among patients with coronary vascular disease
Authors: Reichert Stefan , Schulz Susanne , Benten Ann‐Christin , Lutze Andrea , Seifert Tim , Schlitt Manuela , Werdan Karl , Hofmann Britt , Wienke Andreas , Schaller Hans‐Günter , Schlitt Axel 
Published: August 2016

AbstractAimWe wanted to investigate whether periodontal conditions and/or oral care habits are associated with new cardiovascular events among patients with coronary vascular disease (CVD).Materials and MethodsIn this longitudinal cohort study, 1002 inpatients with CVD were included. They were examined regarding prevalence of severe periodontitis, bleeding upon probing (BOP), number of missing teeth and oral care habits. The combined endpoint was defined as myocardial infarction, stroke/transient ischaemic attack, cardiovascular death and death caused by stroke. Survival analyses were carried out after a 3‐year follow‐up period. Hazard ratios (HRs) were adjusted for known cardiac risk factors using Cox regression.ResultsNine hundred and fifty‐three patients completed the 3‐year follow‐up. The overall incidence of the combined endpoint was 16.4%. Significant HRs for BOP (HR = 2, 95% CI: 1.2–3.3), severe tooth loss (HR = 1.8, 95% CI: 1.3–2.5), brushing teeth more than once a day (HR = 0.6, 95% CI: 0.5–1.0) and use of floss/inter‐dental brushes (HR = 0.5, 95% CI: 0.3–0.9) were evaluated only in univariate but not in multivariate survival analyses. Patients with severe periodontitis achieved the combined endpoint more often (18.9% versus 14.2%), but the result was not statistically significant after both univariate and multivariate survival analyses.ConclusionsPeriodontal conditions and oral care habits are not independent indicators for further adverse events in patients with CVD.