bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exercise and Risk of Cardiovascular Events in Women With Nonmetastatic Breast Cancer
Authors: Jones Lee W. , Habel Laurel A. , Weltzien Erin , Castillo Adrienne , Gupta Dipti , Kroenke Candyce H. , Kwan Marilyn L. , Quesenberry Charles P. , Scott Jessica , Sternfeld Barbara , Yu Anthony , Kushi Lawrence H. , Caan Bette J. 
Published: May 2016

Purpose Cardiovascular disease (CVD) is a leading cause of death among women with nonmetastatic breast cancer. Whether exercise is associated with reductions in CVD risk in patients with breast cancer with an elevated CVD risk phenotype is not known. Methods Using a prospective design, women (n = 2,973; mean age, 57 years) diagnosed with nonmetastatic breast cancer participating in two registry-based, regional cohort studies, completed a questionnaire that assessed leisure-time recreational physical activity (metabolic equivalent task [MET]-h/wk). The primary end point was the first occurrence of any of the following: new diagnosis of coronary artery disease, heart failure, valve abnormality, arrhythmia, stroke, or CVD death, occurring after study enrollment. Results Median follow-up was 8.6 years (range, 0.2 to 14.8 years). In multivariable analysis, the incidence of cardiovascular events decreased across increasing total MET-h/wk categories (Ptrend < .001). Compared with < 2 MET-h/wk, the adjusted hazard ratio was 0.91 (95% CI, 0.76 to 1.09) for 2 to 10.9 MET-h/wk, 0.79 (95% CI, 0.66 to 0.96) for 11 to 24.5 MET-h/wk, and 0.65 (95% CI, 0.53 to 0.80) for ≥ 24.5 MET-h/wk. Similar trends were observed for the incidence of coronary artery disease and heart failure (P values < .05). Adherence to national exercise guidelines for adult patients with cancer (ie, ≥ 9 MET-h/wk) was associated with an adjusted 23% reduction in the risk of cardiovascular events in comparison with not meeting the guidelines (< 9 MET-h/wk; P < .001). The association with exercise did not differ according to age, CVD risk factors, menopausal status, or anticancer treatment. Conclusion Exercise is associated with substantial, graded reductions in the incidence of cardiovascular events in women with nonmetastatic breast cancer.
Randomized, Double-Blind, Phase III Trial of Enzastaurin Versus Placebo in Patients Achieving Remission After First-Line Therapy for High-Risk Diffuse Large B-Cell Lymphoma
Authors: Crump Michael , Leppä Sirpa , Fayad Luis , Lee Je Jung , Di Rocco Alice , Ogura Michinori , Hagberg Hans , Schnell Frederick , Rifkin Robert , Mackensen Andreas , Offner Fritz , Pinter-Brown Lauren , Smith Sonali , Tobinai Kensei , Yeh Su-Peng , Hsi Eric D. , Nguyen Tuan , Shi Peipei , Hahka-Kemppinen Marjo , Thornton Don , Lin Boris , Kahl Brad , Schmitz Norbert , Savage Kerry J. , Habermann Thomas 
Published: May 2016

Purpose To compare disease-free survival (DFS) after maintenance therapy with the selective protein kinase C β (PKCβ) inhibitor, enzastaurin, versus placebo in patients with diffuse large B-cell lymphoma (DLBCL) in complete remission and with a high risk of relapse after first-line therapy. Patients and Methods This multicenter, phase III, randomized, double-blind, placebo-controlled trial enrolled patients who were at high risk of recurrence after rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Patients (N = 758) with stage II bulky or stage III to IV DLBCL, three or more International Prognostic Index risk factors at diagnosis, and a complete response or unconfirmed complete response after 6 to 8 cycles of R-CHOP were assigned 2:1 to receive oral enzastaurin 500 mg daily or placebo for 3 years or until disease progression or unacceptable toxicity. Primary end point was DFS 3 years after the last patient entered treatment. Correlative analyses of biomarkers, including cell of origin by immunohistochemistry and PKCβ expression, with efficacy outcomes were exploratory objectives. Results After a median follow-up of 48 months, DFS hazard ratio for enzastaurin versus placebo was 0.92 (95% CI, 0.689 to 1.216; two-sided log-rank P = .541; 4-year DFS, 70% v 71%, respectively). Independent of treatment, no significant associations were observed between PKCβ protein expression or cell of origin and DFS or overall survival. Conclusion Enzastaurin did not significantly improve DFS in patients with high-risk DLBCL after achieving complete response to R-CHOP. Achievement of a complete response may have abrogated the prognostic significance of cell of origin by immunohistochemistry.
PCSK9 R46L Loss-of-Function Mutation Reduces Lipoprotein(a), LDL Cholesterol, and Risk of Aortic Valve Stenosis
Authors: Langsted Anne , Nordestgaard Børge G. , Benn Marianne , Tybjærg-Hansen Anne , Kamstrup Pia R. 
Published: May 2016

Abstract

Context:
Novel, low-density lipoprotein (LDL) cholesterol-lowering proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors also lower lipoprotein(a) levels, but the effect on aortic valve stenosis and myocardial infarction is unknown.

Objective:
We tested the hypothesis that the PCSK9 R46L loss-of-function mutation is associated with lower levels of lipoprotein(a) and with reduced risk of aortic valve stenosis and myocardial infarction.

Design:
We used two prospective cohort studies of the general population and one patient-based cohort.

Setting:
Cohort studies selected at random individuals of Danish descent.

Participants:
We studied 103 083 individuals from the Copenhagen General Population Study, the Copenhagen City Heart Study, and the Copenhagen Ischemic Heart Disease Study.

Main outcome measures:
Lipoprotein(a), LDL cholesterol, and PCSK9 R46L genotype and diagnoses of aortic valve stenosis and myocardial infarction from national registries; lipoprotein(a) was measured from 49,617 individuals.

Results:
Median (interquartile range) lipoprotein(a) levels were 10 (5–30) mg/dl for PCSK9 R46L noncarriers, 9 (4–32) mg/dl for heterozygotes, and 8 (4–42) mg/dl for homozygotes (trend P = .02). The corresponding values for LDL cholesterol levels were 124 (101–147) mg/dl, 104 (85–132) mg/dl, and 97 (85–128) mg/dl, respectively (trend P = 2 × 10−52). PCSK9 R46L carriers vs noncarriers had an age- and sex-adjusted odds ratio of 0.64 (95% confidence interval, 0.44–0.95) for aortic valve stenosis, 0.77 (0.65–0.92) for myocardial infarction, and 0.76 (0.64–0.89) for aortic valve stenosis or myocardial infarction.

Conclusions:
PCSK9 R46L carriers have lower levels of lipoprotein(a) and LDL cholesterol as well as reduced risk of aortic valve stenosis and myocardial infarction. This indirectly suggests that PCSK9 inhibitors may have a role in patients with aortic valve stenosis.
Complex Reoperation for Late Complications After Acute Type A Aortic Dissection Surgery
Authors: Stöger Guillermo , Ríos Matías , Battellini Roberto , Bracco Daniel , Kotowicz Vadim 
Published: May 2016

AbstractThe correct management of acute Type A dissection continues to be a challenge. The primary goal is to save the patient´s life. However, the decision regarding the surgical approach determines possible later complications. We present the case of a 59-year-old female patient with a past history of emergent surgery for acute Type A dissection treated by supracoronary ascending and aortic valve replacement 19 years previously. Later, in a second endovascular approach, the descending aorta was treated by a thoracic endoprosthesis. During follow-up a dilated aortic root and a Type I endoleak were observed, and complex reoperation was required. We performed a total aortic arch replacement with a 4-branched graft and a complete aortic root replacement using the Cabrol technique for the reinsertion of the coronary arteries. The mechanical aortic normally functioning valve was preserved. The patient was discharged 30 days postoperatively.
Pemisahan Anomali Regional-Residual pada Metode Gravitasi Menggunakan Metode Moving Average, Polynomial dan Inversion
Authors: Purnomo Jarot , Koesuma Sorja , Yunianto Mohtar 
Published: May 2016

<span>It has been done a research about separation of regional-residual anomaly in Gravity method. <span>This research compares the result of three methods i.e. moving average method, polynomial <span>method, and inversion method. The computer program is created using a computer programming <span>Matlab 7. From three methods that have been made, the separation results are compared with<br /><span>results of separation by using Upward Continuation method. From the results of these <span>comparisons will be available an excellent program of regional-residual anomali separation. The <span>results show that in polynomial method of the order 4 obtained similar contour to the separation <span>by Upward Continuation Software. So that the output of this separation will be treated again <span>with Grav2DC software. The output of this software is the density of rock Grav2DC of the study<br /><span>area. Processing results obtained the minimum error of 1.85% for the separation by polynomial <span>method, while for the method of Upward Continuation obtained minimum error of 2.22%. The <span>results obtained show that the separation of regional-residual anomali by polynomial method is <span>similar to separation by Upward Continuation method.</span></span></span></span></span></span></span></span></span></span></span></span><br /></span>
Metode Elektrooptis sebagai Pendeteksi Radikal Bebas dan Prospek untuk Evaluasi Total Mutu Minyak Goreng
Authors: Firdausi K Sofjan , Sugito Heri , Amitasari Ria , Murni Sri 
Published: May 2016

<span>One main problem of standard methods for determination of frying oil quality is various <span>parameter of indicators with their various wide of methods or equipments. In this research we <span>proposed a new method for determination of oil quality using single electrooptics parameter to <span>replace previous indicators. The samples used in the experiment were various conditions of <span>palm oils from the same brand. The level of oil quality was proposed by the value of <span>2<span>, which <span>represents as the relative number of free radicals produced in the sample. The change of <span>polarization was measured by the value of as the samples were induced by an external <span>electric field using high voltage dc power supply. At room temperature of 28 C electrooptics <span>method seems capable to detect free radicals and to distinguish all kinds of palm oils. This <span>method has an opportunity to provide a single parameter of oil quality and an evaluator of <span>halal or authentic food from fats.</span></span></span></span></span></span></span></span></span></span><br /></span></span></span>
Noirscapes: Using the screen to rewrite Los Angeles noir as urban historiography
Authors: Maher Sean , Kerrigan Susan 
Published: May 2016

Abstract
Noirscapes is a transmedia experience, and the cameras are rolling. Writing its own version of Los Angeles’ history, Noirscapes is a filmed scholarly discourse that literally drives through the urban environment of the city of Los Angeles constructing a noir historiography. The authors of this article are film-makerresearchers who, as a mode of creative practice research, are using screens and the medium of film to write with, on and for the screen. The premise of Noirscapes is that film noir can function partly as a surrogate history of Los Angeles, so that film noir screens provide written cinematic evidence of the city’s actual as well as imagined history. Noirscapes presents a series of short films that constitute a creative practice research output. Filming and driving across the freeways and boulevards of present day Los Angeles allowed the film-makers to traverse production locations and to discuss their role in urban historiography, as featured through iconic film noirs like Double Indemnity (1944), Sunset Boulevard (1950) and Chinatown (1974). Noirscapes demonstrates how film-making and spectatorship can be used as complementary research methods that enquire with, on and for the screen.
The effectiveness of using medical students for training high school students in cardiopulmonary resuscitation
Authors: Dîrzu Dan Sebastian , Hagău Natalia , Boţ Theodor , Fărcaş Loredana , Copotoiu Sanda Maria 
Published: May 2016

Abstract

Introduction: Training for cardiopulmonary resuscitation is a very important topic for society, trainers and researchers. However it is not yet established who should be trained and by whom nor how the training programmes should be accomplished. We developed a study to evaluate an existing programme where medical students train high school students in cardiopulmonary resuscitation using instrumented mannequins to teach and collect performance data.

Method: The students of four randomly selected high school classes were trained by four randomly selected medical students and were evaluated by an independent evaluator. The level of knowledge provided and the level of technical skills acquired were analysed.

Results: One hour of lecturing was enough to increase the mean of correct answers from 39.52% to 78.48% when we tested knowledge. Testing for skills retention we found that that 92.75% of trained students taped the shoulder; 95.65% asked loudly “Are you all right?” at the right moment; 97.1% shouted for help at the right moment, the entire group remembered to check the breathing at the right moment, and 92.75% executed a correct head tilt chin lift manoeuvre; 86.9% remembered to call 112 at the right moment. Automatic recordings showed that mean flow fraction was 80.74%, mean no flow time was 18.9 seconds, mean frequency of chest compressions was 134.7/min and mean compression depth was 39.06 mm.

Conclusions: The results showed that high school students achieved a good level of knowledge and acceptable cardiopulmonary resuscitation skills when trained by medical students.
Surgical Strategy in Bouveret's Syndrome. A Case Report
Authors: Dénes Márton István , Török Árpád , Éltes Etele , Kucserik Levente , András Zsolt , Borz Bogdan , Borz Cristian 
Published: May 2016

Abstract
Bouveret's syndrome is a high mechanical obstruction due to impaction of a gallstone into the duodenum, through a cholecystoduodenal fistula. It belongs to a larger group of gallstone ileus, a disease which occurs after developing a fistula between the gallbladder and the gastrointestinal tract. This is a rare complication of gallstones but because it appears in elderly people, it has a high morbidity and mortality. Patients have various symptoms and the treatment is individualized. We present here a case of a 67 years old patient, admitted in emergency, presenting symptoms of high bowel obstruction, with onset 5 days before admission. Abdominal ultrasound reveals a 5 cm stone that seems to be in the gallbladder, gastric stasis and at gastroscopy appears a foreign body impacted in the duodenum. After a short preparation the patient underwent surgery. We found a dilated stomach and a large cholecystoduodenal fistula with an impacted gallstone in the duodenum. We performed one stage surgery: cholecystectomy, extraction of the stone and suturing of the fistula. We reestablished the continuity of the intestinal tract. We performed also an ileostomy for feeding the patient and protecting the anastomoses. The postoperative evolution was favorable.
We consider that one stage surgical treatment in gallstone ileus is an option, if the patient is in good condition and we have an adequate postoperative intensive care management.
A Multiparameter Model for the Correlation Between CT Hounsfield Unit and Blood Components
Authors: Pop Marian , Pop Raluca , Bacarea Anca 
Published: May 2016

Abstract

Objective: To search for a dependency between blood Hounsfield Units values as measured by Computed Tomography and blood components with regards to hemoglobin oxygenated status, demographic data and acquisition parameters.

Methods: A retrospective study included a convenience sample of 144 SCJU patients who underwent routine thoracic CT examinations (Siemens Somatom AS 64 or 128 MDCT) in 2014 and had laboratory examinations done in nearby time. Variables included age, sex, mA, mV, aortic HU values, PA HU values, RBC, HTC, HGB, PLT, WBC blood sugar, PT and INR. Statistical analysis was performed using R version 3.1.1 and MedCalc 12.5 with a statistical significance factor of 0.05.

Results: The examined patients had an average age of 56.25, with a predominance of males (M:F=1.62). While there was a minor difference between HU values in Males vs Females (1.01 HU) it was proven as statistically significant (p=0.0051). No statistical significant difference between oxygenated/non-oxygenated blood (p=0.9636). Regression analysis found positive correlation between HU values and RGB, HGB and HCT with a significance level below 0.0001, the strongest being for the HGB level.

Conclusions: While HU values seem to carry multifactorial sources and the red blood cells being the most important an importance should be given to the fibrinoid plasma components which appear to bear negative impact.
The Role of Supportive Therapy in Pediatric Malignancies
Authors: Papp Zsuzsanna Erzsébet , Horváth Mária-Adrienne 
Published: May 2016

Abstract
Childhood cancer is a major psycho-social and health problem. International study groups establish complex, efficient, and concrete Cytostatic Protocols for every cancer type. During chemotherapy patients become extremely vulnerable to infections, so it is necessary to complete the treatment with blood substitution, anti-infection medication, growth factors and other complementary products.

Materials and Methods: We studied the importance of the wide palette of adjuvant therapy near the intensive cytostatic treatment in the period of March 2014-November 2015 at the hemato-oncology department in Pediatric Clinic of Mures County Hospital.

Results: In this period we treated 20 children (9 female, 11 male) aged between 9 months-18 years. We had 15 cases of haemopathies (13 acute leukemia and two lymphomas), and five solid tumors. Packed red blood cells, platelets, and fresh frozen plasma were given in the aplastic period. A patient benefited, on average, a total of 70ml/kg packed red blood cells and 50 U platelets. For infection prophylaxis and treatment every child benefited associated infective medication.

Discussions: Packed red blood cells, platelets, and fresh frozen plasma were given to patients with a deficiency in the ability to produce normal blood cells which are temporarily worsened by chemotherapy. Antibiotic and antifungal medications are given to all febrile and neutropenic patients. We use wide spectrum antibiotics in association for preventing sepsis. Growth factors are stimulating the bone marrow to increase leukocyte number. Since introducing additional immunostimulant medication, we observed a significant decrease of infection in the aplastic period.

Conclusions: Oncology protocols use only 3-5 cytostatic drugs. Maintaining the patient’s life during the treatment, it is necessary to use a large spectrum of supportive medications.
Tone errors in scripted conversations of L2 Mandarin Chinese
Authors: Yang Chunsheng 
Published: May 2016

AbstractThis study examines the acquisition of Mandarin tones by American English speaking second language (L2) learners. Three types of tone sequences, namely, compatible tone sequences, conflicting tone sequences, and other tone sequences, were used. The analysis of tone errors in different tone sequences showed that, while learners seemed to have acquired the Tone 3 and its sandhi, they tended to over-apply the sandhi rule in inappropriate contexts and produced tone errors. More importantly, the low and rising tones, which are generally difficult for L2 learners to produce, were the most frequent tones produced to replace other tones. More specifically, the low tone errors tended to occur at the phrase-medial position, while the rising tone errors tended to occur at the phrase-initial position. The low and rising tone errors were attributed to the difficulty in quickly changing tone targets and F0 direction in tone production, which is the product of the superimposition of English prosody.
Diazene sulphonate as a cross-linking agent for polymers with pendant triarylamine hole-conducting units
Authors: Baranovicova Eva , Stasko Andrej , Nuyken Oskar 
Published: May 2016

AbstractDiazene sulphonates are readily available compounds which are soluble in water and polar solvents. They strongly absorb the UV-VIS light and they decompose under UV irradiation via radical or ionic intermediates. These properties render them valuable, e.g. for analytical purposes and for photo-printing. In this presentation, it will be demonstrated that polymers with a pendant diazene sulphonate function as cross-linking agents and with pendant aromatic amines as hole-transporters can be considered as useful materials for organic light-emitting device (OLED) technology.
Cohesion and performance in soccer: A causal model
Authors: Gioldasis Aristotelis , Stavrou Nektarios , Mitrotasios Michael , Psychountaki Maria 
Published: May 2016

Abstract
The conceptual model of sport cohesion that Carron developed describes the relationships between cohesion and performance including the antecedents and consequences of the variables. Although researchers have conducted a plethora of studies around the relationship between cohesion and performance, there is a gap in literature regarding longitudinal changes of this relationship as well as its direction. Therefore, the aim of the current study is to examine the relationship between cohesion and performance for soccer teams during a full competitive season as well as the direction of the relationship. The study suggests a new model for the relationship between cohesion and performance. In total, 173 Greek soccer players (M=21.91) completed the Group Environment Questionnaire (Carron et al., 1985) in all the measurements from the beginning of the preparation to the end of the competitive season. The results showed that cohesion and performance are two variables that affect each other in soccer, with a stronger direction from cohesion to performance. However, cohesion affects performance either positively or negatively throughout the season.
Wertfreiheit und Rechtfertigung von Normen im Positivismusstreit / The Positivist Dispute on a Value-Free Science and the Vindication of Norms
Authors: König Eckard 
Published: May 2016

Abstract
The discussion between HABERMAS and ALBERT concerning the problem of ‘Wertfreiheit’ has not yet been finally solved. For this reason it would seem desirable to clarify both positions. In the course of such an explanation, it becomes apparent that the reason for the lack of results between HABERMAS and ALBERT lies in the fact that both authors are talking at cross-purposes. Whereas ALBERT tries to prove that social sciences can be purely empirical and value-free (i.e. containing no value-judgements), HABERMAS is concerned basically not with the question of value-judgements but with that of the value-basis (Wertbasis). On the whole ALBERT assumes that the norms of modern sciences are meaningful and sensible; HABERMAS questions their foundations. His thesis on the ‘technical interest’ (technisches Interesse) does not therefore refer as ALBERT seems to believe to the question of the applicability of empirical sciences but represents an attempt to offer a foundation for these sciences. Admittedly he is only able to make his criticism by presupposing an interest in ‘herrschaftsfreie Kommunikation’ for the explanation of which HABERMAS has suggested several possibilities without as yet having achieved more than initial steps.