bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mechanisms promoting and inhibiting the process of proteasomal degradation of cells
Authors: Pedrycz Agnieszka , Kramkowska Agnieszka 
Published: June 2016

Abstract
Defects in the process of degradation of unneeded cellular proteins underlie many diseases. This article discusses one of the most important systems of removal of abnormal proteins. It describes the process of ubiquitination of proteins for proteasome degradation. It also describes the structure of the 26S and 20S proteasomes and the mechanism of ubiquitin-proteasome system. Proteasome proteolytic system is highly specialized and organized. Protease-proteasome 26S is particularly important for proper cell functioning. It recognizes and degrades marked proteins. Inhibition of proteasome pathway leads to cell cycle arrest and apoptosis.
Efficient degradation of cellular proteins by UPS (the ubiquitin - proteasome system) - is important for signal transduction, transcriptional regulation, response to stress and the activity control of cell receptors.
The development of many diseases has its origin in the dysfunction of the UPS route. This group includes diseases such as cancer, neurodegenerative disorders, immune-mediated diseases and infectious diseases. Development of effective methods for pharmacological intervention in the functioning of this system has become a great challenge. The use of specific, low molecular-weight proteasome inhibitors and enzymes catalyzing the ubiquitination gives hope for new, targeted therapies.
Sustainability by Education: How Latvian Heritage was Kept Alive in German Exile
Authors: Franzenburg Geert 
Published: June 2016

Abstract
Sustainability is one of the core challenges for education in modern times, particularly concerning cultural heritage. The study evaluates, from a German point of view, how Latvians outside of Latvia after World War II kept their cultural heritage alive by educational concepts, which can be characterized as early roots of modern sustainable education. The evaluation focus concerns a group of Latvians in Germany associated with the Latvian high school in Muenster (MLG). The study concerns the 25 years from 1957 (school relocation to Muenster) until 1982 (founding of the organization “Latvian Center of Muenster e.V.” (LCM), and combines interviews and literature research. It underlines that environmental, social and heritage education can be seen as core elements of Latvian education abroad. Therefore, the study will not present a concise history of the Latvian high school in Muenster (MLG), which has already been done (Sprogis, 2009), but will concisely evaluate the educational concepts of this particular period as a model, how Latvians maintained their heritage in a sustainable way.
In-depth Cultural Studies in Multicultural Group
Authors: Siliņa-Jasjukeviča Gunta , Briška Ilze 
Published: June 2016

Abstract
There is much research and educational practices at all levels of education on how to deal with promoting acceptance and understanding between different cultures. A cultural study forms an important part of shaping intercultural understanding. The aim of the research is to analyze an innovative way of incorporating cultural studies in teacher education program from the perspective of encouraging multinational students to reveal common values within diverse manifestations of different cultures. The present article describes a qualitative study of multinational students’ experiences in international project related to the learning about Nordic and Baltic cultural traditions. In the conclusion of the article, the efficiency of the structure of content and the process of in-depth cultural studies are analyzed. The discussion contains problems for further research of this topic.
A Retrospective Introduction to Religious Education: An Interpretive Approach
Authors: Jackson Robert 
Published: June 2016

Abstract
The author takes a retrospective look at his book Religious Education: An Interpretive Approach, first published in 1997, and now available to readers, open access, via the European Wergeland Centre website (http://www.theewc.org/Content/Library/Research-Development/Literature/Introducing-Religious-Education-an-Interpretive-Approach). He tells a personal story of teaching, broadcasting and research, moving from the design of a methodology for studying the religions of minority groups in Britain to identifying the main concepts used for teaching about religions to children and young people in an engaging way, which relates to their own personal and social experience. The article, explains the key concept of representation – looking, for example, at how religions are often represented in ways that play down their internal diversity. Next the concept of interpretation is considered, emphasising the activity through which learners can compare and contrast the use of language by religious believers with their own nearest equivalent language uses, in trying, with sensitivity, to get as close as possible to their meanings. Finally, the process of reflexivity is explained; this gives learners an opportunity for three activities – to re-assess their understanding of their own world view (called edification in the interpretive approach), to make a distanced critique of beliefs and ideas they have studied, and to evaluate the methods that they have been using to learn about the religious meanings of others. Finally the author illustrates how the key concepts from the interpretive approach have been adapted for use in field research studies on teaching and learning about religions.
The ‘Institutions-Individual’ Conceptual Nexus as a Basis of Alternative Economic Methodologies
Authors: Stefanović Zoran , Petrović Dragan 
Published: June 2016

Abstract
This paper discusses issues of methodological basis of contemporary economic theory, from the perspective of rival research orientations and their conceptual sensitization to the role and impacts of institutional structures. In this regard, the paper presents methodological individualism, research support of economic orthodoxy, based on a consistent interpretation of all social phenomena as outcomes of individual choice. It is shown that even in its most rigid versions this approach has to take to a certain degree into account the social interactions that go beyond the individualist framework. The opposing research orientation, methodological holism, gives explanatory primacy to (different) social collective entities and structures, characteristics of which are autonomous in nature and essential for the explanation of the individual as an entity of a lower order, whose individual properties are not significant. Both approaches are subjected to reductionist tendencies - whether explanations of the socioeconomic reality are individual or culturally over-determined. Integrating institutions in consideration of socioeconomic reality has repercussions on the mentioned methodological dichotomy, given that in conceptual terms it has the potential to bridge the extremely individualistic or collectivist methodological positions. Awareness of the impact of institutions on the socioeconomic reality has produced distinctive methodological orientations. Institutional individualism considers institutions as exogenous mechanism whose explanation is at the service of shedding light on the behaviour of the individuals as the main actors of social dynamics, and in that sense this approach can be considered as a milder variant of methodological individualism. The institutionalist extension of methodological holism, methodological institutionalism, understands individual acting as a product of an integrated institutional framework, whose dynamics takes place independently of the individuals, according to its own regularities. Some kind of balance between the aforementioned orientations is offered by methodological systemism, which affirms the dual nature of the actors of social dynamics - as both product of units of a lower order, but also as entities with autonomous, emergent properties. The contextualisation of relations between institutions and individuals in accordance with a system perspective may be a suitable way, with more tuned reality, theoretical valuation and overcoming differences between opponent methodological traditions.
Privatisation and Investment Activity in the Tourism of the Republic of Serbia
Authors: Gligorijević Živorad , Ubavić Predrag 
Published: June 2016

Abstract
As other countries of Central and Southeastern Europe, the Republic of Serbia at the end of the 20th and the beginning of the 21st century entered the process of universal transformation, which in essence represented a powerful political and economic movement for thorough changes in all parts of social and economic life. The central place in total transformational processes was taken by property, that is ownership transformation. The purpose of this research are numerous changes and the effects caused by the ownership transformation, that is privatisation in all economic activities, and in tourism as well. The research methods used in this paper are: analysis method, synthesis method, abstraction method, generalisation method, comparison method, as well as mathematical and statistical methods. The research results show that the effects of the privatisation in the tourism activities of Serbia are rather devastating. Besides, there were no necessary changes in other elements of business transformation (organisational, managerial, personnel, technological and other), what is the decrease in quality of tourist offer in Serbia and its bad position on the international tourism market. Taking into account that the Republic of Serbia has included the development of tourism amongst the priorities of its actual economic policy and development strategy, results of this research should by its originality, scientific approach to the subject of the research, quality and expertise, complete research material in this scientific field, also to point out new possibilities of Serbian tourism development to creators of economic, touristic and investment politics.
Determinants of the Level of Contributions for Pension and Disability Insurance: The EU and Serbia
Authors: Nikolić Milena , Rakić Biljana 
Published: June 2016

Abstract
Both in theory and practice, great attention is paid to the analysis of the pension expenditures level, their determinants, as well as the options for their reduction, whereas the analysis of the revenues level and contributions, as the most significant revenue in contribution-based pension systems, is often neglected. The aim of this paper is to analyse the determinants of the level of contributions for pension and disability insurance in order to identify options for increasing their levels in the pension system of the Republic of Serbia. By using the comparative method, a comparative analysis of data about the trends of the most significant determinants of contribution levels among the European Union Member States and Serbia is performed. Research results have shown that increase in the contribution level for pension and disability insurance in the Republic of Serbia can be achieved by extending the definition of contribution base of employees, increasing the average effective retirement age and increasing the effective population coverage by this insurance. In addition to pointing out the options for increasing the contribution level for pension and disability insurance, the authors also propose the measures which can be applied in order to affect the increase of the contribution level for this insurance and, therefore, the total revenues level of the pension system of the Republic of Serbia.
Trans - Pacific Economic Integration Processes
Authors: Gajinov Dejana 
Published: June 2016

Abstract
Asia-Pacific (AP) region is the world’s most important region today from the viewpoint of long-term economic growth. It is also the extremely important cite of rivalries or partnerships - or both - between China and the United States. The strong expansion of trade, investment and other economic ties within the AP region has stimulated the process of economic integration. The network of bilateral and regional free trade agreements has increased dramatically in recent years, linking virtually all major trading countries in the region, with one exception: either the US or China have not become members of the free trade arrangements involving the other country. The paper examines the scope, principles and characteristics of economic relations and cooperation in the AP region. The issue of whether Asian efforts for regional integration have been compatible with an open multilateral trading system at the global level is also addressed. The paper also assesses changes in the dynamics of regional integration and its future prospects. In this sense, in the Asia Pacific there are now two tracks which lead to the formation of a Free Trade Area of the Asia-Pacific (FTAAP): Asian, based on the Association of Southeast Asian Nations (ASEAN) and the Regional Comprehensive Economic Partnership (RCEP) and trans-pacific, based on Trans-Pacific Partnership (TPP).
Some advances in the theory of quasi-pseudometric type spaces
Authors: Gaba Yaé Ulrich 
Published: June 2016

Abstract
In this paper, we extend most of the results proved in [4]. In particular, we give some topological properties of the quasi-pseudometric type spaces. Moreover, some fixed point and common fixed point theorems are obtained in the setting of quasi-pseudometric spaces, introduced some months ago by Kazeem et al in [4].
Generalized altering distances and fixed point for occasionally hybrid mappings
Authors: Marzouki B. , El Haddouchi A. 
Published: June 2016

Abstract
In this work we are interested in the generalization of the result which is in the article [20]. To realize this, we weaken the two conditions that are : weakly altering distance and occasionally weakly compatible, then we neglect the distance altered because of some changes in theorem.
Total limited packing in graphs
Authors: Hosseini Moghaddam S.M. , Mojdeh D.A. , Samadi B. 
Published: June 2016

Abstract
We define a k-total limited packing number in a graph, which generalizes the concept of open packing number in graphs, and give several bounds on it. These bounds involve many well known parameters of graphs. Also, we establish a connection among the concepts of tuple domination, tuple total domination and total limited packing that implies some results.
A general fixed point theorem for a pair of multi-valued mappings in partial metric spaces
Authors: Popa Valeriu 
Published: June 2016

AbstractThe purpose of this paper is to prove a general fixed point theorem for a pair of multi-valued mappings satisfying a new type of implicit relation in partial metric spaces, which generalizes Theorem 2.2 [4], Theorem 3.1 [3], Theorem 3.2 [7], Corollary 2.3 [4], Theorem 2.8 [16] and obtain other particular results.
Valuation of timber production and carbon sequestration on Järvselja nature protection area
Authors: Adermann Veiko , Padari Allar , Sirgmets Risto , Kosk Aija , Kaimre Paavo 
Published: June 2016

Abstract
Järvselja nature protection area was established in order to preserve and introduce virgin forests, to protect old natural forests, old deciduous forests and habitats of different species. At the same time the stands of nature protection area provide other benefits having both use and non-use values. The goal of the study is to assess the monetary value of the two components of forest ecosystem: timber production and carbon sequestration. The value of timber expresses to forest owners and policy-makers the opportunity cost of nature protection. The carbon sequestration represents the value of new service, highly appreciated in the context of climate policy. While a market for timber and carbon exists, the market-price method has been used for valuation. The data for calculations was obtained from the materials of forest inventory carried out in 2010 by the Department of Forest Management, Estonian University of Life Sciences. According to the calculations the theoretical long-term average value of timber is 325 euros per hectare. The monetary value of timber production is approximately three times higher compared to average productivity of Estonian private forests. The guidelines of Intergovernmental Panel on Climate Change for the inventories of greenhouse gases were used when transforming the growing stock and dead stem timber into biomass and finally into carbon and carbon dioxide. According to the price 4.62 € per ton of tradeable carbon equivalent in autumn 2013, the value of carbon sequestration on Järvselja nature protection area could be estimated 1473 € per hectare of forest land. Because of the high age of stands on nature protection area, the role of forests as a sequestrator of CO2 is remarkable compared to commercial forests. The accumulation of carbon in old-growth natural forests is close to zero, but they still fulfil the role of being a carbon pool.
SMEAR Estonia: Perspectives of a large-scale forest ecosystem – atmosphere research infrastructure
Authors: Noe Steffen M. , Niinemets Ülo , Krasnova Alisa , Krasnov Dmitrii , Motallebi Azimeh , Kängsepp Vivika , Jõgiste Kalev , Hõrrak Urmas , Komsaare Kaupo , Mirme Sander , Vana Marko , Tammet Hannes , Bäck Jaana , Vesala Timo , Kulmala Markku , Petäjä Tuukka , Kangur Ahto 
Published: June 2016

Abstract
Establishment of the SMEAR Estonia at a hemiboreal mixed deciduous broad-leaved-evergreen needle-leaved forest at Järvselja, South-Eastern Estonia, has strongly enhanced the possibilities for national and international cooperation in the fields of forest ecosystem – atmosphere research and impacts of climatic changes on forest ecosystems, atmospheric trace gases, aerosols and air ions. The station provides a multitude of comprehensive continuously measured data covering key climatic and atmospheric characteristics (state and dynamics of solar radiation, trace gases, aerosols and air ions, meteorological parameters) and forest ecosystem traits (net primary productivity, individual tree growth, gas-exchange characteristics, soil variables). The station follows a multidisciplinary and multiscale approach covering processes in spatial dimensions ranging from nanometres to several hundred square kilometres, being thus able to significantly contribute to worldwide measurement networks and the SMEAR network. Here we present an overview of the station, its data produced and we envision future developments towards sustainable research and development of the large-scale scientific infrastructure SMEAR Estonia.
Leaf area index mapping with optical methods and allometric models in SMEAR flux tower footprint at Järvselja, Estonia
Authors: Mõistus Marta , Lang Mait 
Published: June 2016

Abstract
Leaf area index (LAI) characterizes the amount of photosynthetically active tissue in plant canopies. LAI is one of the key factors determining ecosystem net primary production and gas and energy exchange between the canopy and the atmosphere. The aim of the present study was to test different methods for LAI and effective plant area index (PAIe) estimation in mixed hemiboreal forests in Järvselja SMEAR Estonia (Station for Measuring Ecosystem-Atmosphere Relations) flux tower footprint. We used digital hemispherical images from sample plots, forest management inventory data, allometric foliage mass models, airborne discrete-return recording laser scanner (ALS) data and multispectral satellite images. The free ware program HemiSpherical Project Manager (HSP) was used to calculate canopy gap fraction from digital hemispherical photographs taken in 25 sample plots. PAIe was calculated from the gap fraction for up-scaling based on ALS point cloud metrics. The all ALS pulse returns-based canopy transmission was found to be the most suitable lidar metric to estimate PAIe in Järvselja forests. The 95-percentile (H95
) of lidar point cloud height distribution correlates very well with allometric regression models based LAI and in birch stands the relationship was fitted with 0.7 m2 m−2 residual error. However, the relationship was specific to each allometric foliage mass model and systematic discrepancies were detected at large LAI values between the models. Relationships between the spectral reflectance and allometric LAI were not good enough to be used for LAI mapping. Therefore, airborne laser scanning data-based PAIe map was created for areas near SMEAR tower. We recommend to establish a network of permanent sample plots for forest growth and gap fraction measurements into the flux footprint of SMEAR Estonia flux tower in Järvselja to provide consistent up to date data for interpretation of the flux measurements.
Usability evaluation of centered time cartograms
Authors: Ullah Rehmat , Mengistu Eskedar Zelalem , van Elzakker C.P.J.M. , Kraak Menno-Jan 
Published: June 2016

AbstractA time cartogram visualizes travelling-times between locations. It replaces the geographic distance by time distance and distorts the underlyingmap accordingly. By distorting themap, time cartogramsmay give a more intuitive and clear picture of travelling-times. The distortion of the map, however, can make time cartograms harder to recognize and use. Although cartograms are becoming widespread in use, very little is known about their usability. This study focuses on the usability of centered time cartograms: time cartograms that visualize travellingtimes from a fixed starting location to other destinations in a region. We created several centered time cartograms to answer spatio-temporal questions related to the Dutch railway network. Two experiments were performed: a laboratory test and an online survey. In the laboratory test, we used eye-tracking, thinking aloud, and video-recording to compare four different designs of centered time cartograms to find out which one (or combination) of these performs better in answering spatiotemporal questions and thus, to establish a favorable design strategy for these cartograms. In the online survey, centered time cartograms were evaluated against a geographic and schematic map for accuracy, response time, and preference. The first experiment suggested that among various designs, the centered time cartogram with emphasized railroads is the most preferred design and the centered time cartogram without railroads is the least preferred. The second experiment indicated that overall, centered time cartograms perform better than the two other solutions in performing spatio-temporal tasks, particularly when the task has a dominant time-related component.
An efficient multicomponent, one-pot synthesis of Betti bases catalyzed by cerium (IV) ammonium nitrate (CAN) at ambient temperature
Authors: Mekheimer Ramadan Ahmed , Asiri Abdullah Mohamed , Abdel Hameed Afaf Mohamed , Awed Reham R. , Sadek Kamal Usef 
Published: June 2016

Abstract
Starting from readily available 2-naphthol, aldehydes, aryl and alkylamines, a variety of Betti bases were efficiently synthesized utilizing a catalytic amount of cerium (IV) ammonium nitrate (CAN) at room temperature. This protocol has advantages of high yield, mild reaction conditions, no environmental pollution, diversity of reactants and simple work up procedure.