bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analytic bounds on late-time axion-scalar cosmologies
Authors: Shiu Gary , Tonioni Flavio , Tran Hung V. 
Published: September 2024

Abstract
The cosmological dynamics of multiple scalar/pseudoscalar fields are difficult to solve, especially when the field-space metric is curved. This presents a challenge in determining whether a given model can support cosmic acceleration, without solving for the on-shell solution. In this work, we present bounds on late-time FLRW-cosmologies in classes of theories that involve arbitrary numbers of scalar and pseudoscalar fields coupled both kinetically (leading to a curved field space metric) and through scalar potentials. Such bounds are proven analytically, independently of initial conditions, with no approximation in the field equations and without referring to explicit solutions. Besides their broad applications to cosmological model building, our bounds can be applied to studying asymptotic cosmologies of certain classes of string compactifications.
New horizon symmetries, hydrodynamics, and quantum chaos
Authors: Knysh Maria , Liu Hong , Pinzani-Fokeeva Natalia 
Published: September 2024

Abstract
We generalize the formulation of horizon symmetries presented in previous literature to include diffeomorphisms that can shift the location of the horizon. In the context of the AdS/CFT duality, we show that horizon symmetries can be interpreted on the boundary as emergent low-energy gauge symmetries. In particular, we identify a new class of horizon symmetries that extend the so-called shift symmetry, which was previously postulated for effective field theories of maximally chaotic systems. Additionally, we comment on the connections of horizon symmetries with bulk calculations of out-of-time-ordered correlation functions and the phenomenon of pole-skipping.
Adjacencies for recognition of digital Jordan surfaces
Authors: Šlapal Josef 
Published: September 2024

AbstractFor every positive integer, we introduce an adjacency in the digital space $${\mathbb {Z}}^3$$

Z

3

. Connectedness in the graph obtained is then used to define and study digital Jordan surfaces. The surfaces are acquired as polyhedral surfaces bounding the digital polyhedra that can be face-to-face tiled with digital cubes, triangular prisms, square pyramids, and tetrahedra.
Subcutaneous infliximab in Crohn’s disease patients with previous immunogenic failure of intravenous infliximab
Authors: Husman Julia , Černá Karin , Matthes Katja , Gilger Maximilian , Arsova Maia , Schmidt Alexandra , Winzer Nadia , Brosch Anna-Magdalena , Brinkmann Franz , Hampe Jochen , Zeissig Sebastian , Lukáš Milan , Schmelz Renate 
Published: September 2024

Abstract
Purpose
Immunogenicity is a major reason for secondary loss of response to infliximab (IFX). Recent work suggested potentially lower immunogenicity of subcutaneous (SC) compared to intravenous (IV) IFX. However, it is unknown whether re-exposure to IFX SC after secondary loss of response and immunogenicity to its intravenous formulation is safe and effective.

Methods
In a retrospective cohort study conducted at two medical centers, patients with clinically (Harvey-Bradshaw Index ≥ 5) and/or biochemically (fecal calprotectin > 250 µg/g) active Crohn’s disease (CD) and previous immunogenic failure of IFX IV underwent exposure to IFX SC. Harvey-Bradshaw Index, fecal calprotectin, IFX serum concentration, and anti-drug antibodies were assessed until month 12.

Results
Twenty CD patients were included. The majority of patients (90%) had previous treatment with three or more biologics. Fifteen (75%) and ten (50%) of 20 patients continued IFX SC treatment until months 6 and 12, respectively. No immediate hypersensitivity reactions were observed. Two patients discontinued IFX SC treatment because of delayed hypersensitivity at week 2 and week 4. IFX serum concentrations increased from baseline to month 12, while anti-drug antibody levels decreased. Combined clinical and biochemical remission at month 12 was observed in seven of 20 patients (35%).

Conclusion
Subcutaneous infliximab treatment of Crohn’s disease patients with previous immunogenic failure of intravenous infliximab was well tolerated and effective in a cohort of patients with refractory Crohn’s disease.
Contactin proteins in cerebrospinal fluid show different alterations in dementias
Authors: Muqaku Besnik , Anderl-Straub Sarah , Werner Leonie , Nagl Magdalena , Otto Markus , Teunissen Charlotte E. , Oeckl Patrick 
Published: September 2024

Abstract
Background
The proteins contactin (CNTN) 1–6 are synaptic proteins for which there is evidence that they are dysregulated in neurodegenerative dementias. Less is known about CNTN changes and differences in cerebrospinal fluid (CSF) of dementias, which can provide important information about alterations of the CNTN network and be of value for differential diagnosis.

Methods
We developed a mass spectrometry-based multiple reaction monitoring (MRM) method to simultaneously determine all six CNTNs in CSF samples using stable isotope-labeled standard peptides. The analytical performance of the method was evaluated for peptide stability, dilution linearity and precision. CNTNs were measured in 82 CSF samples from patients with Alzheimer’s disease (AD, n = 19), behavioural variant frontotemporal dementia (bvFTD, n = 18), Parkinson’s disease dementia/dementia with Lewy bodies (PDD/DLB, n = 18) and non-neurodegenerative controls (n = 27) and compared with core AD biomarkers.

Results
The MRM analysis revealed down-regulation of CNTN2 (fold change (FC) = 0.77), CNTN4 (FC = 0.75) and CNTN5 (FC = 0.67) in bvFTD and CNTN3 (FC = 0.72), CNTN4 (FC = 0.75) and CNTN5 (FC = 0.73) in PDD/DLB compared to AD. CNTN levels strongly correlated with each other in controls (r = 0.73), bvFTD (r = 0.86) and PDD/DLB (r = 0.70), but the correlation was significantly lower in AD (r = 0.41). CNTNs in AD did not show correlation even with core AD biomarkers. Combined use of CNTN1-6 levels increased diagnostic performance of AD core biomarkers.

Conclusions
Our data show CNTNs differentially altered in dementias and indicate CNTN homeostasis being selectively dysregulated in AD. The combined use of CNTNs with AD core biomarkers might help to improve differential diagnosis.
The role of evaluatively conditioned stimuli in iconic memory
Authors: Clausen Alexandra E. , Kattner Florian 
Published: September 2024

AbstractIn the present study, an attempt was made to replicate results found about the influence of valence on prioritisation and decay in iconic memory. Hereby, the evaluative conditioning effect was used to induce valence for formerly neutral stimuli. The effect is gained by pairing neutral stimuli with either positive, negative, or neutral images in a conditioning phase. Afterwards, the conditioned stimuli acted as targets in an iconic memory test. In the iconic memory test, targets were presented together with seven other stimuli on a circular placement on the screen for a short time. A cue delayed by either 17, 68, 221, 493, or 1003 ms pointed at the target to be reported. Participants rated the targets before and after the conditioning phase. In addition, the affective and neutral images used in the pairing procedure were rated at the end of the experiment. While no significant change in rating could be observed for the conditioned targets, a significant effect of conditioned valence was still present in the response times and the accuracy of the iconic memory test. Participants reacted the quickest in response to a cue for positively conditioned targets compared to neutral or negatively conditioned targets. Accuracy was highest for positively conditioned targets and was lowest for negatively conditioned targets. Unlike in prior studies, slower decay of information in iconic memory for negative targets was not revealed. Further research should be conducted to identify reasons for this inconsistency.
Benign acute childhood myositis: a scoping review of clinical presentation and viral etiology
Authors: Majava Elli , Renko Marjo , Kuitunen Ilari 
Published: September 2024

AbstractBenign acute childhood myositis is a benign phenomenon often associated with influenza in children. The aim of this scoping review was to analyze the typical clinical picture and characteristics of benign acute childhood myositis patients. Furthermore, we aimed to analyze the epidemiology and viral findings. We performed a systematic scoping review. We searched PubMed, Scopus, Web of Science, and CINAHL databases in August 2023. We included observational studies that focused on children and reported at least 10 children. Our main outcome was to describe the typical clinical picture of benign acute childhood myositis patients. Furthermore, we aimed to report the typical laboratory findings and virus findings. A total of 211 studies were screened, and 22 studies were included in this review. The included studies were mainly from Europe (13 studies) and Asia (5 studies). Two studies were prospective, and the rest were retrospective. The mean age of the patients was 6.8 (CI 5.8–7.8) years. Benign acute childhood myositis appeared to be more prevalent among boys in all studies. The most prevalent symptoms were bilateral leg pain (pooled prevalence 92%), followed by fever (80%) and inability to walk (56%). Hospitalization rates varied between 4 and 100%, and the mean hospital stay was 3.6 (CI 3.3–3.9) days. Influenza B was the most common virus detected, followed by influenza A. Other reported viruses included herpes simplex, coxsackie-, enteroviruses, adeno-, respiratory syncytial, and parainfluenza viruses. All studies reported creatinine kinase levels, and the reported mean values varied between 100 and 4000 U/L, whereas only five studies reported C-reactive protein which was only slightly elevated. Conclusion: According to a systematic assessment of published literature, benign acute childhood myositis patients were typically school-aged children, presenting with bilateral leg pain, fever, and inability to walk. Influenza A and B were the most reported viruses, but multiple other viruses have been associated with benign acute childhood myositis. These patients have high creatinine kinase values, but their hospital stay was rather short. Overall, this review provides important information for clinicians on the characteristic presentation of benign acute childhood myositis, and these findings may help to better identify these patients and reduce unnecessary tests.

What is known:• Benign acute childhood myositis has been mainly associated with influenza viruses, especially B influenza.• Typical patients have been reported to be under school-aged children, and boys have been reported to have a higher incidence.

What is new:• Many non-influenza viruses were also associated with benign acute childhood myositis, such as herpes simplex, coxsackie-, entero-, adeno-, respiratory syncytial, and parainfluenza viruses.• Typical symptoms are bilateral calf pain, fever, and inability to walk and creatine kinase levels were reposted to be increased.
Survival after surgery for lung cancer among patients with autoimmune diseases
Authors: Nagano Masaaki , Cong Yue , Nakao Keita , Kawashima Mitsuaki , Konoeda Chihiro , Sato Masaaki 
Published: September 2024

Abstract
Purpose
While patients with autoimmune diseases (ADs) are at high risk for developing specific malignancies, including lung cancer, ADs may protect against the development of cancer through increased immune cell activity in tumors. This study aimed to investigate whether the presence of ADs affects surgical outcomes and survival after surgery for lung cancer.

Methods
The medical records of 1236 patients who underwent surgery for non-small cell lung cancer between 2007 and 2018 were retrospectively reviewed. Perioperative and long-term outcomes were compared between patients with and without ADs using propensity score matching.

Results
Among the included patients, 115 with ADs and 1121 without ADs underwent surgery. Using 1-to-1 propensity score matching, 114 pairs were selected. Although there were no significant differences in the perioperative outcomes of the two groups, the overall and relapse-free survival rates were significantly lower in the group with ADs than in the group without ADs.

Conclusions
Surgery for lung cancer can be performed without increasing the complications in patients with ADs. However, the long-term outcomes were significantly worse in patients with ADs than in those without ADs, suggesting that close follow-up for lung cancer and careful whole-body examination might be needed for patients with ADs.
Sensitivity of horizontal resolution and land surface model in operational WRF forecast for Online Nuclear Emergency Response System (ONERS)
Authors: Karmakar Shanu , Rajeswari J. R. , Kundu Dipan , Srinivas C. V. , Chandrasekaran S. , Venkatraman B. 
Published: September 2024

AbstractAccurate Meteorological forecasts are crucial for the assessment of plume dispersion and dose prediction in nuclear power plant (NPP) sites. In this work the forecast sensitivity of the Weather Research and Forecasting (WRF) model is tested by running a series of forecast simulations for horizontal resolution, and land surface models (LSM) in the context of Online Nuclear Emergency Response System (ONERS) for Indian NPP sites. 72 h forecast simulations are made for three seasons viz. summer, southeast and northeast monsoon using the Global Forecast data. Three simulation experiments, namely 2 km-NOAH, 3 km-NOAH and 3 km-NOAHMP are conducted using two different nested domain configurations (18–6–2 km and 9–3 km) and two LSM schemes (NOAH and NOAH-MP) and tested at four different NPP sites. Forecast comparison of surface winds, relative humidity, temperature, heat fluxes and planetary boundary layer heights with data from meteorological tower, radiosonde and the Modern-Era Retrospective analysis for Research and Applications 2 (MERRA-2) shows 3 km-NOAH is equally capable in predicting surface parameters as well as vertical profiles compared to 2 km-NOAH with marginal differences. 3 km-NOAHMP shows less mean bias and better correlation for boundary layer height and heat fluxes. Comparison of spatial flow-field with 5th generation European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis (ERA5) data shows synoptic scale seasonal winds, sea level pressure systems and temperature hot-spots are better captured by 3 km-NOAHMP compared to 6 km coarse domain in the 18–6–2 km configuration. The daily accumulated rainfall by all simulations is overestimated compared to ERA5 data. The predictions by 3 km-NOAHMP better agree with Integrated Multi-satellite Retrievals for Global Precipitation Measurement (GPM-IMERGE) data whereas 2 km-NOAH predicts delayed rainfall occurrence. Dispersion simulations of hypothetical plume release from a coastal NPP site with all three forecasts properly show the influence of local scale diurnal land-sea breeze and seasonal winds on the plume movement. Therefore the 9–3 km domain with NOAHMP LSM is found to be a suitable choice for operational weather forecast in ONERS for Indian NPP sites.
Chloroplasts with clefts and holes: a reassessment of the chloroplast shape using 3D FE-SEM cellular reconstruction of two species of Chlamydomonas
Authors: Sato Naoki , Sato Mayuko , Wakazaki Mayumi , Moriyama Takashi , Hirashima Takashi , Toyooka Kiminori 
Published: September 2024

AbstractChloroplasts are usually considered spheroid organelles, but this is not the only shape of chloroplasts. The chloroplast of Chlamydomonas has been typically described as cup-shaped. However, in old studies, it was also modeled as a complex shape with “perforations” or windows. Here, we reconstructed the cellular architecture of Chlamydomonas reinhardtii and C. applanata using an array tomography system installed on a field emission scanning electron microscope. C. reinhardtii chloroplasts resembled a baseball glove or a cup without a side, featuring numerous large and small holes that may facilitate the transport of metabolites and proteins produced in the Golgi apparatus fitted in the holes. In a lipid-accumulating, high-light condition, the chloroplast volume increased by filling the side cleft with an entire wall. Many accumulated large lipid droplets were accommodated within the chloroplast holes, which could have been considered as “chloroplast lipid droplets.” Mitochondrial meshworks surrounded the chloroplast. C. applanata chloroplasts appeared like a folded starfish or a cup with many side clefts and a few holes. There was a single mitochondrion or two that branched in a complex form. Tight contacts of various organelles were also found in C. applanata. These reconstructions illustrate the complexity of chloroplast shape, which necessitates a revised understanding of the localization of lipid droplets and the evolution of chloroplasts: The prevailing image of the spheroid chloroplasts that reminds us of the similarity between chloroplasts and cyanobacteria is no longer tenable.
Comparative overall survival analysis of chordomas of the base of the skull from the Surveillance, Epidemiology, and End Results (SEER) program between 2000 and 2020
Authors: Agner Kevin E. , Larkins Michael C. 
Published: September 2024

AbstractChordomas of the skull base are rare, slow growing, locally invasive cancers with limited long-term survival analysis reported in the literature. We seek to provide comparative survival analysis of patients on a long-term (20-year) basis using population-level data. The Surveillance, Epidemiology, and End Results (SEER) program was queried for cases of chordoma relegated to the base of the skull, diagnosed between 2000 and 2020. Demographic, disease, and treatment information were analyzed using Cox proportional hazards and log-rank comparisons. 630 patients with chordoma of the skull base were identified. Age ≤ 49 years at diagnosis was associated with increased five-, 10-, and 20-year overall survival (hazard ratio (HR) = 0.39, 0.33, and 0.30, respectively; p < 0.001 for all). Treatment with surgery and adjuvant radiotherapy was associated with increased five-, 10-, and 20-year survival (HR = 0.71, 0.79, and 0.79, respectively; p < 0.001 for all). On univariate analysis, widowed patients had decreased survival (20-year overall survival = 34.8% [15.3%-34.8%] compared to married patients (74.4% [68.1%-80.8%]. Surgery remains the primary treatment associated with increased survival among patients with chordoma of the skull base, with adjuvant radiotherapy serving a complimentary role. Demographic factors such as marital status are also associated with changes in survival.
The regime complex for digital trade in Asia and China’s engagement
Authors: Gao Xinchuchu , Chen Xuechen 
Published: September 2024

AbstractThe rapid development of information and communication technologies over the past two decades has resulted in profound transformations in traditional economic and trade activities, leading to the scaling of digital trade across the Asian region and beyond. Drawing on the conceptual framework of the regime complex, this article seeks to delineate the main features of regional digital trade governance in the Asian region and China’s engagement with the regime-building process in this policy field. It demonstrates that the digital trade governance landscape in Asian countries comprises a collection of partially overlapping and nonhierarchical regimes, where different regional actors are formulating competing visions and approaches to digital trade governance. In addition, the dynamic nature of the digital trade regime complex in Asia and China’s evolving approach to digital trade governance is mutually constitutive. By selectively liberalizing in certain contexts while remaining conservative in others, China contributes to a more complex and less cohesive regional digital trade environment. China’s emphasis on standard-setting efforts and security considerations introduces additional complexities to the regime complex, potentially impeding the development of comprehensive governance regimes for digital trade in the region.
Leap, learn, earn: exploring academic risk taking and learning success across gender and socioeconomic groups
Authors: Hübner Vanessa , Pfost Maximilian 
Published: September 2024

Abstract
Background
The positive learning effects of academic risk taking (ART) in higher education has been discussed since the 1980s. However, this may not apply equally for all social groups. Men and women may differ in the way they use ART to construct their gender identity. Students with different socioeconomic status (SES) may differ in their ability to navigate academic risks due to differences in available cultural capital.

Aims
This study examines gender and SES disparities in ART and their impact on learning success. It explores if ART mediates and is moderated by gender and SES effects. Additionally, it assesses if ART directly predicts learning success.

Sample
A sample of N = 381 German university students was used.

Methods
Data was analyzed following a structural equation modeling approach.

Results
Men show more ART on the seminar group dimension, whereas women show more ART on the peer dimension. Being male indirectly predicts higher learning success via the seminar group dimension of ART. Furthermore, SES and gender moderate the effect between ART and learning success. Both ART dimensions directly predict students’ learning success.

Conclusions
Our research contributes to understanding the mechanisms of social disparities within higher education and offers implications for the development of inclusive teaching strategies and research on aspects of intersectionality.
Isotope characterisation of groundwater resources in uranium impacted Fazilka, Punjab
Authors: Ghosh Anushree , Pant Diksha , Kajla Manju , Mohokar Hemant , Jaryal Ajay , Keesari Tirumalesh 
Published: September 2024

AbstractGroundwater is the most reliable source for freshwater supplies in India and abroad. Population rise has affected the groundwater resources both in terms of quality and quantity. Punjab, being an agrarian state, is highly dependent on groundwater resources for both irrigation and drinking purposes. Recent studies have indicated presence of uranium in groundwater especially in southwestern parts of Punjab. In this research, water samples were collected from Fazilka district of Punjab for evaluating the water quality focussing uranium and identifying source and recharge processes of groundwater. Uranium concentration was found in both shallow and deep groundwater samples. Inter-ionic correlations signify that alkalinity and electrical conductivity of the water samples control the uranium mobilization from the aquifer matrix. Isotopic systematics demonstrate that groundwater recharge is mainly through rainwater infiltration.