bluuebunny/crossref_metadata_2025_split huggingface dataset:
An atypical E3 ligase safeguards the ribosome during nutrient stress
Authors: Douglas Todd , Zhang Jiasheng , Wu Zhiping , Abdallah Kyrillos , McReynolds Meghan , Gilbert Wendy V. , Iwai Kazuhiro , Peng Junmin , Young Lawrence H. , Crews Craig M. 
Published: October 2024

SUMMARYMetabolic stress must be effectively mitigated for the survival of cells and organisms. Ribosomes have emerged as signaling hubs that sense metabolic perturbations and coordinate responses that either restore homeostasis or trigger cell death. As yet, the mechanisms governing these cell fate decisions are not well understood. Here, we report an unexpected role for the atypical E3 ligase HOIL-1 in safeguarding the ribosome. We find HOIL-1 mutations associated with cardiomyopathy broadly sensitize cells to nutrient and translational stress. These signals converge on the ribotoxic stress sentinel ZAKα. Mechanistically, mutant HOIL-1 excludes a ribosome quality control E3 ligase from its functional complex and remodels the ribosome ubiquitin landscape. This quality control failure renders glucose starvation ribotoxic, precipitating a ZAKα-ATF4-xCT-driven noncanonical cell death. We further show HOIL-1 loss exacerbates cardiac dysfunction under pressure overload. These data reveal an unrecognized ribosome signaling axis and a molecular circuit controlling cell fate during nutrient stress.
Arginine methylation coordinates with phosphorylation to regulate NADP+synthesis
Authors: Zhu Yue , Zhang Wanjun , Hu Mengxue , Xing Xiaoke , Li Yanze , Zhang Hemeng , Zhao Yuanyuan , Chen Luojun , Zhang Chunmin , Chen Yali , Qin Weijie , Han Suxia , Pei Huadong , Zhang Pingfeng 
Published: October 2024

AbstractNADK is the sole cytosolic enzyme responsible for synthesizing NADP+from NAD+within cells. The homeostasis of NAD+/NADP+is controlled by NADK, usually dysregulated in various cancers, yet the precise underlying regulatory mechanisms remain largely unknown. In this study, we discover that PRMT6 methylates NADK at R39, R41, and R45, resulting in the suppression of NADK kinase activity and NADP+synthesis. Mutations of these sites promote cancer cell proliferation and tumor growth. PRMT6-mediated methylation of NADK coordinates with Akt-mediated phosphorylation to regulate NADK, which stimulates its activity to increase NADP+production through relief of an autoinhibitory function inherent to its amino terminus. PRMT6 also inhibits NADK activity in a phosphorylation-independent manner. Furthermore, NADK methylation is upregulated by RB1/E2F pathway in high-fat diet mice. Downregulation of NADK methylation in HCC enhances NADP+production to promote cancer development. Our findings illuminate the molecular regulatory mechanisms governing NAD+/NADP+homeostasis, suggesting that the PRMT6-NADK axis emerges as a direct player in high energy state. Furthermore, our research suggests potential therapeutic targets through chemical and genetic interventions.SignificancePrevious studies revealed that phosphorylation of NADK activates its activity in response to nutrient or other signaling pathways. Here, we discovered that PRMT6 methylates NADK at residues R39, R41, and R45, leading to the suppression of NADK kinase activity and NADP+synthesis. This PRMT6-mediated methylation works in conjunction with Akt-mediated phosphorylation to regulate NADK. Additionally, we found that NADK methylation is upregulated by the RB1/E2F pathway in mice on a high-fat diet. In hepatocellular carcinoma (HCC), the downregulation of NADK methylation enhances NADP+production, thereby promoting cancer development. Our findings provide a significant breakthrough in understanding the regulation of NADK and its response to environmental factors.
Building personal and relational readiness for collaborative teacher mentoring through the intellectual virtues
Authors: Larsen Ellen , Curtis Elizabeth , Mai Nguyen Hoa Thi , Loughland Tony 
Published: October 2024

PurposeContemporary early career teacher (ECT) mentoring approaches have largely aspired to shift towards a more non-hierarchic and mutually beneficial learning partnership approach. Such mentoring can be challenging to achieve. We report on a project that sought to further understand how intellectual virtues, such as intellectual courage, open-mindedness and humility, may be mobilised to prepare ECTs and mentors for more collaborative mentoring conversations.Design/methodology/approachUsing qualitative case study research design, we collected data from 31 mentors and ECTs across two states in Australia engaged in professional learning focused on developing mentors’ and ECTs’ understanding of intellectual virtues as a resource for mentoring conversations. Data were generated from online professional learning activities, a questionnaire and field notes from school site visits and thematically analysed.FindingsECTs and mentors reported an increased self-awareness of their dispositional strengths and limitations and heightened confidence to engage in conversations that were more equal and open. Teachers perceived the deployment of intellectual virtues for mentoring to have personal, relational and learning benefits.Originality/valueNumerous mentoring studies have espoused the value of mentoring that takes a co-constructivist and deeply relational approach, yet there is limited guidance provided to teachers as to how such an approach may be achieved. This paper innovatively draws on intellectual virtues as a cognitive construct to explore this issue and makes an empirical contribution to understanding how to prepare mentors and early career teachers for non-hierarchical and relational mentoring conversations.
Why do refugees live near to each other? A utility-based model for spatial segregation of Syrian refugees in Türkiye: 2016–2023 period
Authors: Akgül Taylan , Elitaş Zeynep 
Published: October 2024

PurposeThe main purpose of this research is to understand and explain the clustering and/or segregation patterns of the rapid, massive and unexpected flow of Syrian refugees to Türkiye.Design/methodology/approachThe analytical framework we use consists of three parts. In the first stage, we created a two-group model in which utility is assumed to be a function of consumption and the proportion of the population belonging to the same group living in their neighborhood. We show that equilibrium utility can be reduced to a univariate function that is the population proportion of the group to which one belongs. Then, with the help of a Python-based simulation, we analyze the redistribution dynamics of the groups and clustering patterns. In the final stage, we compute the dissimilarity index to determine the degree of clustering.FindingsAlthough the dilution policy has been implemented, a relatively high spatial segregation of refugees still exists. The dissimilarity index we compute using the latest data shows that almost half of Syrians need to be displaced for a homogeneous geographical distribution.Research limitations/implicationsBy obtaining neighborhood-based housing data, it will be possible to conduct a more detailed analysis at the city level. This will improve policymakers' understanding of refugee policy at both local and national levels.Originality/valueIt is the first study in which a dissimilarity index is computed for Syrian refugees in Türkiye.
Policy improvement of the dynamical movement primitives and stiffness primitives framework for robot learning variable stiffness manipulation
Authors: Ren Danmei , Bian Feifei 
Published: October 2024

Purpose
Human beings are able to adjust their arm stiffness in daily life tasks. This paper aims to enable a robot to learn these human-like variable stiffness motor skills autonomously.

Design/methodology/approach
The paper presents a reinforcement learning method to enable a robot to learn variable stiffness motor skills autonomously. Firstly, the variable stiffness motor skills are encoded by the previously proposed dynamical movement primitives and stiffness primitives (DMP-SP) framework, which is able to generate both motion and stiffness curves for robots. The admittance controller is then used to make a robot follow the motion and stiffness curves. The authors then use the policy improvement with path integrals (PI2) algorithm to optimize the robot motion and stiffness curves iteratively.

Findings
The performance of the proposed method is evaluated on an UR10 robot by two different tasks: a) via-point task, b) sweeping the floor. The results show that after training, the robot is capable of accomplishing the tasks safely and compliantly.

Practical implications
The method can help the robots walk out of the isolated environment and accelerate their integration into human being’s daily life.

Originality/value
This paper uses reinforcement learning method to improve DMP-SP framework, thus allowing the robots to learn variable stiffness motor skills autonomously with no need for extra sensors.
How differently do cognitive and affective country image affect brand loyalty
Authors: Nguyen Ngoc Minh , Hoang Giang Huong , Vu Ngoc Thi Minh , Bui Linh Duy , Ta Anh Son 
Published: October 2024

Purpose
This paper aims to examine how differently cognitive and affective country image affects brand loyalty of smartphone brands from two developed countries in Vietnam and how product image mediates these effects.

Design/methodology/approach
This research used the cross-sectional design. Data was collected via questionnaires and 517 responses were left after refining. The confirmatory factor analysis and structural equation modeling were applied to analyze the collected data.

Findings
The effects of the cognitive country image on brand loyalty are totally transmitted through product image. The effects of affective country image on brand loyalty are divided into direct and indirect effects transmitted through product image.

Research limitations/implications
Affective country image and product image have complementary effects, whereas cognitive country image and product image have substituting effects on brand loyalty.

Practical implications
International companies from countries with unfavorable country images should concentrate more on improving their product images to improve brand loyalty in foreign markets.

Originality/value
The findings support previous studies, which have shown that cognitive and affective country images are distinctive dimensions of country image and affect consumer cognition and responses toward products/brands through different mechanisms.
The effect of business owners’ personal characteristics on enterprises’ human resource management strategies – a multigroup comparison model based on micro, small and medium-sized private enterprises
Authors: Li Chengyan , Huang Chongrong , Sun Liuqi , Song Tingting 
Published: October 2024

PurposeIt has been proven that the characteristics of top management in an organization have an impact on the organization’s employee management strategies. In micro, small and medium-sized enterprises, the business owner’s influence is constructive. However, there has been little discussion about the influence of business owners’ personal characteristics on enterprises’ human resource management (HRM) strategies.Design/methodology/approachIn this study, two complementary experimental designs – quantitative research and qualitative research – were adopted to verify the theoretical framework.FindingsThe results show that business owners with masculine characteristics tend to adopt the strategies of internal development and external acquisition, while those with feminine characteristics tend to adopt the strategies of internal development. Significant differences were found between the female business owner group and the male business owner group in terms of the relationship paths of gender role orientation, leadership style and gender role orientation and HRM strategies.Originality/valueFirstly, this is the first time to discuss human resource management strategies from the perspective of gender roles. Secondly, the data of this research is collected from entrepreneurs, which is another advantage of this research. Finally, this research has obtained more valuable research findings. This study found that feminine bosses tend to adopt internally developed human resource strategies, while masculine bosses value internally developed human resource management strategies and also tend to adopt external acquisition strategies. Studies have shown that companies that adopt defensive strategies rely more on internally developed human resource management strategies, while those with exploratory strategies are more inclined to externally acquired human resource management strategies. So, does the boss’s gender role orientation match the organizational strategy, that is, feminine bosses adopt defensive strategies, while masculine bosses adopt defensive and exploratory organizational strategies? This point provides new research ideas for the development of private enterprises.
The impact of project-related failures on team members and support mechanisms – a narrative analysis
Authors: Chiponde Danstan Bwalya , Gledson Barry , Greenwood David 
Published: October 2024

Purpose
Past studies on project-related failures (PRF) have focused more on developing criteria for measuring project success and failure and achieving project outputs without addressing the impact of PRF on team members. Therefore, this study aims to focus on reviewing the impact of PRF on team members and the support offered by leaders.

Design/methodology/approach
A qualitative research approach was adopted, and data was collected through interviews involving 15 construction professionals. The data was analysed using the narrative data analysis method whilst adopting just culture theory as a theoretical lens.

Findings
Failure impacts team members’ emotions and morale negatively in form of grief, stress and in some cases death. Family and personal relationships are strained due to the financial burden of losing employment. Support offered to team members mostly increased training and supervision with a focus on meeting the project outputs (time, cost and quality) without addressing the emotional and morale-related impact of failure on team members. Instead team members are blamed and punished, which demonstrates a prevalence of a retributive response to failure.

Research limitations/implications
Considering the limited number of participants, the study’s findings cannot be generalised. Hence, future studies with a large population are encouraged.

Practical implications
The implications for practice are that team members should be supported emotionally besides retraining/upskilling and supervision. Accordingly, there is need to adopt a just culture which focuses on who are affected and how they can be supported instead of focusing on who to blame.

Originality/value
Unlike studies that focus on the criteria for measuring and mitigating project with the view of achieving project outputs, this study encourages providing emotional support to team members.
A comprehensive framework of visual elements in brand logos: content analysis of top 500 global brands
Authors: Trehan Shruti , Kalro Arti D. 
Published: October 2024

Purpose
Designers must recognise the significance of a brand logo’s visual elements as they convey various meanings. While studies have attempted to collate visual elements, efforts have often been limited to specific types of visual elements (e.g. typefaces) or restricted to certain product categories. This study aims to conceptualise a comprehensive list of visual elements used in brand logos and to validate it based on the top 500 global brand logos across eight product categories.

Design/methodology/approach
A comprehensive list was conceptualised through a combination of literature review, interviews with experts and observations of real brand logos. Using this exhaustive compilation, content analysis of the top 500 global brand logos was conducted to discern the prevalent trends of the visual elements in logos across various product categories.

Findings
The content analysis results highlighted an extensive preference for use of wordmark, no outline and horizontal proportion in brand logos. Overall, 42.6% and 31% of brands preferred using cool and neutral colours, respectively. Moreover, the preference for colour categories (warm/cool/neutral), font types (organic/geometric) and stacking of elements (horizontal/vertical/diagonal) varied across product categories.

Originality/value
This study contributes to the literature by creating a comprehensive guidebook of visual elements of logos. It also offers guidance to in-house and third-party designers of companies for logo design to better understand the nuances of intellectual property related to logo elements and assists managers in comparing their brands’ visual identity with those of their competitors.
The role of family support on the effects of paramedic role overload on resilience, intention to leave and promotive voice
Authors: Meacham Hannah , Holland Peter , Pariona-Cabrera Patricia , Kang Haiying , Tham Tse Leng , Bartram Timothy , Cavanagh Jillian 
Published: October 2024

PurposeParamedics have played a critical role in the health care system response to the COVID-19 pandemic as frontline responders. However, in comparison to other health care workers (i.e. nurses), less research has been conducted on how paramedic work has been undertaken and how they manage their resources in the context of high workloads. This study examines several factors that deplete paramedic resources as well as the importance of family support in buffering the effects of low levels of resilience that can impact paramedic intention to leave and promotive voice.Design/methodology/approachData were collected from 648 paramedics employed by Ambulance Victoria, Australia, during the COVID-19 pandemic. We examine five hypotheses: (1) resilience mediates the relationship between role overload and intention to leave; (2) resilience mediates the relationship between role overload and promotive voice; (3) family support moderates the relationship between role overload and resilience; (4) family support moderates the indirect effect of role overload on intention to leave via resilience and (5) family support moderates the indirect effect of role overload on promotive voice via resilience.FindingsWe found that when family support was low, the impact of role overload on turnover intention via resilience was significant. When family support was low, the negative impact of role overload on promotive voice via resilience was significant. When family support was high, such a negative indirect effect was not significant in predicting employee promotive voice via resilience.Practical implicationsWe suggest that organisations should focus human resource management (HRM) policies and practices on family-friendly initiatives to further enhance family support resources to benefit individuals, families and organisations.Originality/valueOur findings demonstrate the importance of family support as a buffer to the negative effects of role overload on employee resilience and promotive voice. There is clear importance of the contextual elements of family support as a resource, and its absence may result in resource depletion and can act as a catalyst in a resource depletion spiral. This demonstrates the importance of organisations understanding and learning to utilise external resources to complement organisational and individual resources to reduce intention to leave and support promotive employee voice. We suggest that organisations should focus HRM policies and practices on family-friendly initiatives to further enhance family support resources to benefit individuals, families and organisations.
Exploring child marriage in Yemen: a critical analysis of an Arab media corpus
Authors: Mohammed Tawffeek A.S. 
Published: October 2024

PurposeThis study adopts a qualitative approach to a critical media analysis of the multifaceted aspects of child marriage in the Yemeni context as an example of the broader Arab context. It seeks to provide a deeper understanding of the current situation, underlying causes and consequences of child marriage, as well as efforts to curb the practice.Design/methodology/approachThis study utilizes a thematic analysis approach, examining various textual and multimodal sources on child marriage. A corpus of Arab media, including news and opinion articles, online discussions and public comments, was compiled and analyzed. Additionally, sentiment analysis techniques were employed to examine a YouTube report about Nujood Ali, a victim of child marriage in Yemen, to gauge the emotional tone and attitudes of viewers towards the media coverage and the practice itself.FindingsThis study identifies prevalent themes, narratives and perspectives related to child marriage in Yemen, highlighting the diverse journalism genres addressing the issue. The thematic analysis of the media corpus reveals several themes that align with findings from other studies, particularly those discussing the practice, its causes and its prevalence. The sentiment analysis of a YouTube report on Nujood Ali reveals significant insights into the public’s emotional response and attitude towards child marriage.Research limitations/implicationsThis study is limited to the content available in the compiled corpus and the specific methodologies employed, including thematic and sentiment analysis. These limitations might influence the generalizability of the findings.Originality/valueThis study is distinctive in its comprehensive and multidisciplinary approach to examining child marriage in Yemen and the broader Arab context. It employs a selection of digital humanities software to attempt a systematic, critical media analysis on child marriage in Yemen. Thematic analysis has uncovered unique insights, such as the inadvertent consequences of legislation intended to protect children, which have instead exacerbated the problem. In addition, the media has highlighted the negative role played by some religious scholars in Yemeni Parliament. These scholars have used their political power and immunity to obstruct efforts to end the practice, either directly or by mobilizing their supporters. A sentiment analysis of YouTube comments clearly indicates that the practice of child marriage is not widely accepted within the Yemeni community, despite some perceptions to the contrary.
Prurigo chronica multiformis: Expert consensus of the Japanese Dermatological Association
Authors: Satoh Takahiro , Murota Hiroyuki , Aoyama Yumi , Hashimoto Takashi , Ishiuji Yozo , Hatano Yutaka , Nakahara Takeshi , Kabashima Kenji , Takamori Kenji , Katayama Ichiro 
Published: October 2024

AbstractPrurigo chronica multiformis is a commonly used diagnostic designation for a peculiar subtype of prurigo in Japan, although the disease entity might not be well‐recognized in other countries. Experts approved by the Japanese Dermatological Association attempted to build a common consensus on prurigo chronica multiformis, agreeing that it is a unique and important disease entity in elderly patients. Skin lesions are characterized by intensely pruritic, edematous, urticarial papules, or small macules, which gradually become solid papules/small nodules. The papules tend to aggregate and occasionally coalesce into polygonal lichenified plaques. The most commonly affected sites are the lower abdomen and lower back, although the chest, thighs, and upper back might also be involved. Common histopathological features of prurigo chronica multiformis include infiltration of lymphocytes and eosinophils in the upper dermis, with minimal epidermal changes. Basophil infiltration is also observed. The epidemiological incidence, differences in clinical manifestations by geographical location, and disease placement among other forms of prurigo and/or related skin diseases need to be further elucidated. Dermatologists should be aware of the clinical characteristics of prurigo chronica multiformis.