bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green Endoscopy and Sustainable Practices: A Scoping Review
Authors: Koo Thai Hau , Tee Vincent , Lee Yeong Yeh , Roslan Nur Sakinah , Ibrahim Yusof Shuaib 
Published: September 2024

Abstract
Objectives The emergence of “green endoscopy” arises from the increasing global need to reform environmental sustainability due to climate change. Our review aimed to provide current evidence surrounding green endoscopy on sustainable issues including environmental impact, innovations, guidelines, policies, future directions, and recommendations.
Materials and Methods A scoping review was conducted following the Preferred Reporting Items for Systematic Review and Meta-Analysis extension for scoping reviews guidelines. Full-text English articles from established databases were screened for eligibility criteria and analyzed.
Results Out of 7,892 identified articles, 28 met all the eligibility criteria. Key findings include (1) the significant environmental impact of single-use items in current endoscopic practices; (2) there are emerging green innovations in endoscopy, such as reusable instruments, eco-friendly sterilization methods, and energy-efficient technologies; (3) guidelines and green policies are increasingly available to provide clinical guidance and framework for health care facilities; (4) model institutions can provide case studies and examples of implementing green endoscopy; and (5) unified efforts from all stakeholders are needed to address challenges, including cost-effectiveness.
Conclusion A paradigm shift toward green endoscopy is clearly in place and should be driven by the need to reduce environmental impact, be cost-effective, and not sacrifice patient safety.
Vinblastine-Induced Posterior Reversible Encephalopathy Syndrome in Pediatric Hodgkin Lymphoma
Authors: Siddartha Thippeswamy K. M. , Sindgikar Seema Pavaman , Sheety Vijith 
Published: September 2024

AbstractPosterior reversible encephalopathy syndrome (PRES) is a critical care scenario seen with several etiologies. We report a pediatric case of Hodgkin lymphoma presenting with paraneoplastic features of nephrotic syndrome (NS). Diagnosis was confirmed with positron emission tomography-computed tomography scan and immunohistochemistry of the tissue biopsy. Remission for NS was achieved within a week of starting chemotherapy (ABVD–adriamycin, bleomycin, vinblastine, and dacarbazine). After the second cycle, he developed headache, seizures, and hypertension, requiring intensive care management. Magnetic resonance imaging brain was suggestive of PRES. The condition was managed with antihypertensives, antiepileptics, and supportive care. Considering all the risk factors for PRES including the drug, vinblastine, further chemotherapy was administered with only ABD regimen. The child attained complete remission after six cycles of chemotherapy and did not have any further episodes of hypertension or seizures. This case highlights the rare complication of vinblastine in a complicated lymphoid malignancy.
Evolution of Robotics in Neurosurgery
Authors: Shaikh Salman T. , Dwarakanath T.A. , Moiyadi Aliasgar V. 
Published: September 2024

AbstractTechnology and neurosurgery have gone hand in hand since a long time. Technological development of robotics in neurosurgery over the last couple of decades has been rapid, yet it still has a long way to go before it becomes a “routine” element of the standard neurosurgical procedure. Apart from the obvious advantages they have over humans, that is, precision, consistency, endurance, and reproducibility, robots also provide additional freedom of movement beyond what is anatomically feasible for humans. Since its first practical application in 1985, the promise of robotics has spurred development and design of numerous such devices for application in neurosurgery. In the current era, the role of robots in neurosurgery is limited to programming movements and planning trajectories for deep cranial targets, biopsies, spinal screw placements, deep brain stimulation, and stereotactic radiosurgery. This narrative, nonsystematic review discusses the evolution of various robotic systems, with a focus on their neurosurgical applications.
Cauda Equina Cavernous Angioma
Authors: Jacob Adrian Jamesraj , Mangaleswaran Balamurugan , Jacob Sheba , M.K Saranraj 
Published: September 2024

AbstractCavernous angiomas are rare vascular lesions, most occurring supratentorially, with spinal cavernomas being even rarer. They have a varied magnetic resonance imaging (MRI) appearance which is usually not diagnostic. A 42-year-old man presented with progressive low backache for the past 5 years and was found to have a mild right ankle weakness. MRI showed an intradural extramedullary lesion at the L1 vertebral body level. Intraoperatively, a dark reddish-blue mulberry-like lesion was found attached to a nerve root that had to be sacrificed during the excision. Histopathology confirmed that it was a cavernous angioma and the patient had no added deficits postoperatively. Cauda equina cavernomas are extremely rare and hence not thought of as a differential preoperatively. They are relatively simple to remove but will mostly need the sacrifice of the adherent nerve root. Most cases do well postoperatively with stable deficits and some improving.
Investigating the Thickness of the Deltoid Free Flap Using Ultrasonography and Clinical Application in Foot and Hand Soft-Tissue Defect Reconstruction
Authors: Ngoc-Huyen Nguyen , The-Hoang Nguyen , Quang-Vinh Nguyen , Staudenmaier Rainer 
Published: September 2024

Abstract
Background Although the deltoid flap is widely described as a thin flap, no studies have reported on the measurement of its thickness. Thus, this study aimed to measure deltoid flap thickness at different points using brightness-mode ultrasonography and report our initial clinical experience.
Methods This study included 36 adults (26 males and 10 females; mean age: 34 years) with 72 healthy deltoid regions. Ultrasonography was employed to measure flap thickness at eight designated positions. The ultrasonography results were also applied clinically in 30 patients to evaluate its compatibility.
Results The mean deltoid flap thickness was 5.14 ± 0.81 mm, with the thickest point being the emerging point of the flap pedicle. The subcutaneous fat gradually thinned toward the shoulder. No significant differences in the subcutaneous fat layer thickness were observed between the right and left sides, different ages, or the two sexes. Body mass index was the most critical factor related to flap thickness (p < 0.001). All deltoid free flaps were successfully transferred, resulting in good or excellent final clinical outcomes.
Conclusion The ultrasonography results suggest harvesting the deltoid flap upward toward the shoulder area and across the acromion from the emerging position of the flap pedicle to optimize flap thinness. The results showed that besides the flaps that have been clinically well established, the deltoid flap should be considered a valuable alternative for reconstructing limb soft-tissue defects, particularly where thin flaps are required and favorable aesthetic results are crucial.
Efficacy of Ketamine as an Adjuvant to Scalp Block for Hemodynamic Stability in Patients Undergoing Elective Craniotomy for Supratentorial Glioma: A Prospective Randomized Controlled Trial
Authors: Kaushal Ashutosh , Pathak Sharmishtha , Gupta Priyanka , Talwar Praveen , Jain Anuj , Karna Sunaina Tejpal 
Published: September 2024

Abstract
Introduction Scalp nerve block (SNB) attenuates the hemodynamic response to pin insertion and delivers excellent postoperative analgesia. This study aimed to evaluate the efficacy of SNB using ketamine as an adjuvant to bupivacaine on perioperative hemodynamic responses and postoperative pain in patients undergoing craniotomy for supratentorial glioma.
Materials and Methods Sixty patients were randomized into two groups. They were given scalp nerve block either with bupivacaine and saline (group S) or bupivacaine and ketamine (group K). Primary outcome was to compare the change in mean arterial pressure (MAP) and heart rate (HR) at defined time points from baseline. Secondary outcomes included time to request for first analgesia, total analgesic consumption in intraoperative and postoperative periods till 24 hours, and numeric rating scale pain score at various time points in postoperative period till 24 hours.
Results Fifty-seven patients were included in analysis. HR and MAP were comparable intraoperatively till closure. As soon as closure began, a significant increase in HR (group K vs. group S, 69.76 ± 9.03 vs. 93.96 ± 9.98, p-value = < 0.0001) and MAP (group K vs. group S, 79.4 ± 4.12 vs. 87.17 ± 12.67, p-value = 0.002) was noted in group S patients. This increase persisted in the postoperative period as well. The median total opioid consumed during intraoperative period in group K was 200 mcg versus 300 mcg in group S, p-value < 0.0001.
Conclusion Adding ketamine as an adjuvant to bupivacaine for SNB not only provides significant hemodynamic stability but also reduces both intra- and postoperative analgesic consumption.
Suspending life, controlling change: cryotechnology, genetic identity, and ecological separation
Authors: Wolff Leon 
Published: September 2024

AbstractThe collection and freezing of plant seeds in gene banks has been an integral part of global biodiversity policy since the early twentieth century. In recent years, the use of cryopreservation technologies (the storage of biological material at temperatures as low as −196 °C) has been advocated as a complement to these strategies. This technology promises that it will be possible to freeze significantly more plant varieties for longer periods of time. The article draws on scientific publications to analyze the current discourse on cryopreservation technology in the field of agricultural plant conservation. It underpins and intensifies biopolitical trajectories that have been inherent in ex situ conservation from the outset. First, cryotechnology submits to a pure line ontology which frames living beings as having an intrinsic genetic identity, and aims to secure this genetic identity against unplanned changes. Second, cryopreservation is linked to an imaginary of ecological separation that implies the idea that biodiversity can ultimately be preserved without a habitat. The article concludes by pointing to the material limitations and unsolved problems cryotechnologies inevitably face.
Role of green finance and higher education in fostering the sustainability and energy transition practices
Authors: Meng Bingfeng , Hao Zhihao 
Published: September 2024

AbstractThis paper offers a qualitative analysis of how higher education and green finance impact the promotion of sustainable energy within the Regional Comprehensive Economic Partnership (RCEP) region from 2000 to 2020. The analysis reveals that higher education has a positive effect on sustainable energy development, with a 1% increase in the higher education population associated with a 0.19% rise in short-term and a 0.29% rise in long-term sustainable energy progress. Green finance also plays a crucial role, significantly accelerating green energy development in the RCEP region—each 1% increase in green finance results in a 0.43% boost in short-term and a 0.38% boost in long-term sustainable energy advancement. In contrast, increased fossil fuel production hampers sustainable energy development. Enhanced internet access further supports green energy progress, contributing to a 0.43% increase in the short-term and a 0.53% increase in the long-term. Policy recommendations include expanding the green finance market, advancing sustainable education initiatives, reducing reliance on fossil fuels, and improving internet access to further sustainable energy development in the RCEP region.
Effect of thermal annealing on the average and local structure of superconducting polycrystalline NbRe films
Authors: Makhdoumi Kakhaki Z , Martinelli A , Avitabile F , Di Bernardo A , Attanasio C , Cirillo C 
Published: September 2024

Abstract

Nb
x

Re

1
−
x

is a non-centrosymmetric superconductor recently realized in thin film form. The access to the basic physics that governs this material is hindered by the polycrystalline structure of the films which consist of grains of small dimensions. In these conditions, films are not decisive in revealing the nature of the superconducting order parameter, and, in particular, the possible presence of a spin-triplet component. In this work, post-deposition annealing procedures were performed to improve the crystalline quality of the as-grown films. As determined by x-ray diffraction measurements, by tuning the annealing process, it was possible to increase the crystalline size from 1–2 nm up to several nanometers, beyond the values of the superconducting coherence length. Pair distribution function analyses revealed the non-centrosymmetric crystal structure of the treated NbRe films. Finally, electrical transport measurements, performed to study the relationship between structural and transport properties of the samples, showed an improved metallicity and a reduction of the superconducting critical temperature after the thermal treatment. This last result can be reasonably ascribed, for instance, to oxygen contamination, modification of the electronic density of states at the Fermi level, or change in the electron–phonon coupling. The results of this work are useful to realize films for future experiments meant to access nature of the superconducting order parameter.
Decoding Judicial Cross-Citations: How Do European Judges Engage with Foreign Case Law?
Authors: De Witte Folker , Krisztián Anna , Kukavica Jaka , Potocka-Sionek Nastazja , Siems Mathias , Yiatrou Vasiliki 
Published: September 2024

Abstract
How do judges engage with foreign case law? While prior research has identified some instances of courts willing to cite foreign judgments, details about the mode of engagement and the motivation of such cross-citations have often been left unexplored. This Article fills these gaps. It presents the results of the coding of a sample of 456 judgments with cross-citations between the private law supreme courts of twenty-eight European countries. Twenty-five variables were coded for each citation: for example, the length of the discussion of foreign case law, whether the court was interested in the result or the reasoning of foreign judgments, and whether the citations occurred within the context of EU law, international law and/or specific areas of the law. This Article presents and contextualizes (i.e., “decodes”) this quantitative information. Amongst others, we find that courts from common law countries more often cite older foreign case law and provide a greater depth of engagement with it than courts from civil law countries, that many of the courts are mainly interested in the result and not the reasoning of foreign judgments, that most cross-citations are driven by reasons of comparative law (and not, for example, EU law or international law), and that cross-citations due to EU law are particularly prevalent in IP law and conflict of laws. More generally, we observe a form of bifurcation of citations across many of the topics analyzed, suggesting a divide, not between common and civil law countries, but between courts from smaller and larger jurisdictions (e.g., with smaller jurisdictions using citations in more traditional areas of law, citing mainly one other court, citing older cases, and more often being interested in the reasoning of foreign judgments).
Expanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases
Authors: Jiao Jingjing , Morotti Raffaella , Shafizadeh Nafis , Jain Dhanpat 
Published: September 2024

Abstract

Objectives
Progressive familial intrahepatic cholestasis (PFIC) is a group of autosomal recessive disorders caused by defects in bile secretion or transport usually presenting as cholestasis in pediatric age. Herewith, we describe 3 PFIC cases with diagnostic challenges and highlight the role of genetic analysis.

Methods
The clinical history, laboratory data, liver biopsy, and molecular analysis for each case were reviewed.

Results
Case 1, a Hispanic male from Puerto Rico with hepatomegaly since age 2 months, was eventually diagnosed with PFIC3 following identification of a homozygous splice site variant in ATP binding cassette subfamily B member 4 (ABCB4) (c.2784-12T&gt;C) at age 17 years by whole-exome sequencing (WES). Case 2 was a 37-year-old man with a history of alcoholism, abnormal liver function tests, and ductopenia on biopsy. Molecular testing revealed a pathogenic heterozygous ABCB4 mutation (c.1633C&gt;T) variant leading to a diagnosis of PFIC3. Case 3 was a 2-year-old female initially presenting as a drug-induced liver injury but was diagnosed with PFIC10 following identification of a heterozygous frameshift mutation (p.Asp300Trpfs*19) and a heterozygous missense mutation (c.1357T&gt;C) in myosin VB (MYO5B) by WES.

Conclusions
These PFIC cases highlight the heterogenous presentation and diagnostic challenges, and they emphasize the role of next-generation sequencing, particularly the utility of WES.
Feasibility and Clinical Effectiveness of Computer-Based Cognitive Rehabilitation in Illiterate and Low-Educated Individuals with Mild Cognitive Impairment: Preliminary Data
Authors: Petri Maria Christina , Messinis Lambros , Patrikelis Panayiotis , Nasios Grigorios , Dimitriou Nefeli , Nousia Anastasia , Kosmidis Mary H 
Published: September 2024

Abstract

Objective
We investigated the feasibility of the RehaCom cognitive rehabilitation software in illiterate and low-educated individuals with mild cognitive impairment (MCI) and its clinical effectiveness in improving cognitive functions.

Methods
Twenty illiterate or low-educated individuals with MCI were randomly assigned to an intervention (IG; n = 10) and control group (CG; n = 10). The IG participated in the cognitive enhancement program for 6 weeks, twice a week and a duration of 50–60 min for each session, while the CG did not receive any kind of intervention.

Results
The two groups were demographically matched. The IG successfully completed all sessions of the cognitive enhancement program. A within-subject comparison between baseline and post-intervention assessment of cognitive functions indicated that the IG improved significantly on all administered neuropsychological tests, in contrast to the CG, whose performance remained stable between baseline and final assessment. A between-group comparison found statistically significant differences between the IG and CG groups on the Hindi Mental State Examination, Mini-Mental State Examination, and on delayed memory and recognition tasks, in favor of the IG.

Conclusions
The findings of the present study support the feasibility of applying computerized cognitive enhancement programs to illiterate and low-educated individuals. Moreover, these programs appear to contribute positively to improving the cognitive functions of this population group. In order to generalize and confirm similar findings in a broader population of illiterate and low-educated individuals, future studies should include larger samples, possibly with longer duration of treatment and control groups that will receive non-targeted interventions as placebo interventions.
Synergistic effect of cerium chloride and calcium chloride alters calcium signaling in keratinocytes to promote epidermal differentiation
Authors: Tsukui Kei , Suzuki Masamitsu , Amma Miyu , Tokudome Yoshihiro 
Published: September 2024

Abstract
Epidermal keratinocytes undergo morphological and functional changes during differentiation, eventually being enucleated to become corneocytes. Calcium has been shown to be involved in various cellular functions of epidermal cells, including proliferation, differentiation, and apoptosis. Cerium is a lanthanide-series element and rare earth metal. For skin, cerium oxide has been investigated for use in absorbing UV and promoting wound healing. However, the functions and physiological effects of inorganic cerium on the skin have rarely been investigated. Here, we focused on cerium's function in epidermal keratinocytes and its interaction with calcium by investigating their effects on cell differentiation and intracellular calcium concentration. This study showed that applying cerium chloride to epidermal keratinocytes altered calcium signaling. It also suggested that cerium and calcium induced an increase in intracellular calcium concentration and promoted keratinocyte differentiation.
FAVOR-GPT: a generative natural language interface to whole genome variant functional annotations
Authors: Li Thomas Cheng , Zhou Hufeng , Verma Vineet , Tang Xiangru , Shao Yanjun , Van Buren Eric , Weng Zhiping , Gerstein Mark , Neale Benjamin , Sunyaev Shamil R , Lin Xihong 
Published: September 2024

Abstract

Motivation
Functional Annotation of genomic Variants Online Resources (FAVOR) offers multi-faceted, whole genome variant functional annotations, which is essential for Whole Genome and Exome Sequencing (WGS/WES) analysis and the functional prioritization of disease-associated variants. A versatile chatbot designed to facilitate informative interpretation and interactive, user-centric summary of the whole genome variant functional annotation data in the FAVOR database is needed.

Results
We have developed FAVOR-GPT, a generative natural language interface powered by integrating large language models (LLMs) and FAVOR. It is developed based on the Retrieval Augmented Generation (RAG) approach, and complements the original FAVOR portal, enhancing usability for users, especially those without specialized expertise. FAVOR-GPT simplifies raw annotations by providing interpretable explanations and result summaries in response to the user’s prompt. It shows high accuracy when cross-referencing with the FAVOR database, underscoring the robustness of the retrieval framework.

Availability and implementation
Researchers can access FAVOR-GPT at FAVOR’s main website (https://favor.genohub.org).
Second-order group knockoffs with applications to genome-wide association studies
Authors: Chu Benjamin B , Gu Jiaqi , Chen Zhaomeng , Morrison Tim , Candès Emmanuel , He Zihuai , Sabatti Chiara 
Published: September 2024

Abstract

Motivation
Conditional testing via the knockoff framework allows one to identify—among a large number of possible explanatory variables—those that carry unique information about an outcome of interest and also provides a false discovery rate guarantee on the selection. This approach is particularly well suited to the analysis of genome-wide association studies (GWAS), which have the goal of identifying genetic variants that influence traits of medical relevance.

Results
While conditional testing can be both more powerful and precise than traditional GWAS analysis methods, its vanilla implementation encounters a difficulty common to all multivariate analysis methods: it is challenging to distinguish among multiple, highly correlated regressors. This impasse can be overcome by shifting the object of inference from single variables to groups of correlated variables. To achieve this, it is necessary to construct “group knockoffs.” While successful examples are already documented in the literature, this paper substantially expands the set of algorithms and software for group knockoffs. We focus in particular on second-order knockoffs, for which we describe correlation matrix approximations that are appropriate for GWAS data and that result in considerable computational savings. We illustrate the effectiveness of the proposed methods with simulations and with the analysis of albuminuria data from the UK Biobank.

Availability and implementation
The described algorithms are implemented in an open-source Julia package Knockoffs.jl. R and Python wrappers are available as knockoffsr and knockoffspy packages.