bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative phytochemical, antioxidant, and hemostatic studies of fractions from raw and roasted sea buckthorn seeds in vitro
Authors: Sławińska Natalia , Żuchowski Jerzy , Stochmal Anna , Olas Beata 
Published: September 2024

AbstractVarious seeds, including sea buckthorn (Hippophae rhamnoides L.) seeds, are sources of different bioactive compounds. They can show anti-inflammatory, hypoglycemic, anti-hyperlipidemic, antibacterial, antioxidant, or other biological properties in in vitro and in vivo models. Our preliminary in vitro results have demonstrated that the extracts from raw (no thermal processing) and roasted (thermally processed) sea buckthorn seeds have antioxidant potential and anticoagulant activity. However, it was unclear which compounds were responsible for these properties. Therefore, in continuation of our previous study, the extracts were fractionated by C18 chromatography. Phytochemical analysis of three fractions (a, b, and c) from raw sea buckthorn seeds and four fractions (d, e, f, and g) from roasted sea buckthorn seeds were performed. Several in vitro assays were also conducted to determine the antioxidant and procoagulant/anticoagulant potential of the fractions and two of their major constituents—isorhamnetin 3-O-β-glucoside7-O-α-rhamnoside and serotonin. LC–MS analyses showed that serotonin is the dominant constituent of fractions c and f, which was tentatively identified on the basis of its HRMS and UV spectra. Moreover, fractions c and f, as well as b and e, contained different B-type proanthocyanidins. Fractions b and e consisted mainly of numerous glycosides of kaempferol, quercetin, and isorhamnetin. The results of oxidative stress assays (measurements of protein carbonylation, lipid peroxidation, and thiol groups oxidation) showed that out of all the tested fractions, fraction g (isolated from roasted seeds and containing mainly dihexoses, and serotonin) demonstrated the strongest antioxidant properties.
ISB 2001 trispecific T cell engager shows strong tumor cytotoxicity and overcomes immune escape mechanisms of multiple myeloma cells
Authors: Carretero-Iglesia Laura , Hall Olivia J. , Berret Jérémy , Pais Daniela , Estoppey Carole , Chimen Myriam , Monney Thierry , Loyau Jeremy , Dreyfus Cyrille , Macoin Julie , Perez Cynthia , Menon Vinu , Gruber Isabelle , Laurendon Amélie , Caro Lydia N. , Gudi Girish S. , Matsuura Tomomi , van der Graaf Piet H. , Blein Stanislas , Mbow M. Lamine , Croasdale-Wood Rebecca , Srivastava Ankita , Dyson Michael R. , Matthes Thomas , Kaya Zeynep , Edwards Claire M. , Edwards James R. , Maiga Sophie , Pellat-Deceunynck Catherine , Touzeau Cyrille , Moreau Philippe , Konto Cyril , Drake Adam , Zhukovsky Eugene A. , Perro Mario , Pihlgren Maria 
Published: September 2024

AbstractDespite recent advances in immunotherapies targeting single tumor-associated antigens, patients with multiple myeloma eventually relapse. ISB 2001 is a CD3+ T cell engager (TCE) co-targeting BCMA and CD38 designed to improve cytotoxicity against multiple myeloma. Targeting of two tumor-associated antigens by a single TCE resulted in superior cytotoxic potency across a variable range of BCMA and CD38 tumor expression profiles mimicking natural tumor heterogeneity, improved resistance to competing soluble factors and exhibited superior cytotoxic potency on patient-derived samples and in mouse models. Despite the broad expression of CD38 across human tissues, ISB 2001 demonstrated a reduced T cell activation profile in the absence of tumor cells when compared to TCEs targeting CD38 only. To determine an optimal first-in-human dose for the ongoing clinical trial (NCT05862012), we developed an innovative quantitative systems pharmacology model leveraging preclinical data, using a minimum pharmacologically active dose approach, therefore reducing patient exposure to subefficacious doses of therapies.
Room-temperature ferromagnetic semiconductor Fe-doped β-Ga2O3 thin films with high saturation magnetization and low coercivity
Authors: Gong Dan , Zhang Xi , Dai Xu , Tan Yongjia , Peng Yong , Xiang Gang 
Published: September 2024

Fe-doped β-Ga2O3 DMS film exhibits high Ms and low Hc (70 emu cm−3 and 12 Oe at 300 K). The high Ms originates from the Ga vacancy-enhanced ferromagnetic coupling between the BMPs.
Acoustic Analysis of Spatiotemporal Variability in Children With Childhood Apraxia of Speech
Authors: Vuolo Janet , Wisler Alan 
Published: September 2024

Purpose:
The purpose of this study was to investigate acoustic spatiotemporal variability in children with childhood apraxia of speech (CAS) compared to children with typical development (TD). Increased spatiotemporal variability in children with CAS relative to nonapraxic peers has been documented in multiple kinematic studies. To date, few studies have investigated spatiotemporal variability in CAS using an acoustic signal.

Method:
Data were drawn from 10 children with CAS and 10 children with TD, ranging in age from 5;0 to 11;2 (years;months), who participated in an online study. All children with CAS had a verified diagnosis and showed at least five CAS features across at least two tasks, independently confirmed by two speech-language pathologists with expertise in CAS. Children repeated the sentences “Buy Bobby a puppy” (BBAP) and “Mom pets the puppy” (MPP) 10 times each. The acoustic spatiotemporal index (STI), calculated from the amplitude envelope, was used to investigate acoustic spatiotemporal variability. Using a regression analysis, we analyzed group differences in STI values while controlling for age and gender.

Results:
Children with CAS did not produce enough usable tokens of BBAP to analyze. MPP revealed significantly higher acoustic STI values in children with CAS compared to children with TD. No significant effects were observed for age or gender. Acoustic data collected online without the use of specialized equipment yielded high-quality audio data from which amplitude envelope tracing could be reliably accomplished.

Conclusions:
This study adds to a growing body of empirical data indicating that children with CAS produce speech with more variable spatiotemporal control compared to children with TD. In addition to producing more variable speech, children with CAS were less consistently able to form productions free of phonetic errors. These findings also demonstrate the feasibility of using remote data collection to investigate acoustic spatiotemporal variability, which allows for the recruitment of larger samples of low-incidence populations.

Supplemental Material:

https://doi.org/10.23641/asha.26814883
Craniofacial and Velopharyngeal Dimensions in Infants 0–12 Months: Between- and Within-Group Differences Based on Age and Sex
Authors: Power Samantha J. , Piccorelli Annalisa V. , Jones David L. , Neuberger Ilana , Allen Gregory C. , Barhaghi Krystle , Kotlarek Katelyn J. 
Published: September 2024

Purpose:
The purpose of the present study is to (a) provide quantitative data on the growth of levator veli palatini (LVP), velopharyngeal (VP), and craniofacial dimensions in children under 12 months while controlling for corrected age and sex and (b) compare variability within age and sex groups.

Method:
Magnetic resonance imaging scans of 75 infants between 0 and 12 months were measured and divided into four age groups. These data were obtained as part of a larger retrospective study. Following exclusion criteria, scans were analyzed, and dependent variables were obtained.

Results:

There was a statistically significant (
p
< .0001) difference between corrected age groups on LVP muscle, VP, and craniofacial variables while controlling for sex. Significant growth effects were observed for LVP length (
p
< .0001), extravelar length (
p
< .0001), intravelar length (
p
= .048), midline thickness (
p
= .0001), origin–origin distance (
p
< .0001), velar length (
p
< .0001), velar thickness (
p
= .003), nasion–sella turcica distance (
p
< .0001), sella turcica–basion distance (
p
< .0001), and hard palate length (
p
< .0001). Significant sex effects were observed for pharyngeal depth (
p
= .026) and effective VP ratio (
p
= .014). When age was treated as a continuous variable, similar results were observed for all variables except pharyngeal depth. Within-group comparisons revealed the most variability occurs between 3 and 5.99 months for LVP and craniofacial variables and between 9 and 11.99 months of age for VP variables. Male participants demonstrated greater variability than female participants.

Conclusions:
Differences were observed in LVP, VP, and craniofacial variables in children under 12 months while controlling for sex. Males demonstrated larger values and greater variability for most variables.
Adductor Laryngeal Dystonia Versus Muscle Tension Dysphonia: Examining the Utility of Automated Acoustic Analysis to Detect Task Dependency as a Distinguishing Feature
Authors: Roy Nelson , Awan Shaheen N. , Jennings Skyler , Jensen Jenna , Merrill Ray M. 
Published: September 2024

Objective:
Differentiating adductor laryngeal dystonia (ADLD) and primary muscle tension dysphonia (pMTD) can be challenging. Unlike pMTD, ADLD is described as “task-dependent” with voiced phonemes purportedly provoking greater sign expression than voiceless phonemes. We evaluated the ability of two automated acoustic measures, the Cepstral Spectral Index of Dysphonia (CSID) and creak, to detect task dependency and to discriminate ADLD and pMTD.

Method:

CSID, % creak, and listener ratings of dysphonia severity were obtained from audio recordings of patients with ADLD (
n
= 29) or pMTD (
n
= 33) reading two sentences loaded with either voiced or voiceless phonemes.

Results:

Group × Sentence Type interaction effects confirmed that both “normalized” CSID and % creak detected task-dependent sign expression in ADLD (i.e., worse symptoms on the voiced- vs. voiceless-loaded sentence). However, a stepwise binary logistic regression analysis with group (ADLD vs. pMTD) as the dependent variable and % creak and normalized CSID variables (voiced, voiceless, and voiced vs. voiceless difference) as covariates revealed that the normalized CSID voiceless-laden sentence
z
score was the only significant predictor of group membership. Estimates of diagnostic precision from the normalized CSID voiceless sentence
z
scores were superior to % creak or listener ratings. Finally, the CSID possessed the strongest correlations with listener severity ratings regardless of group or sentence type.

Conclusions:

Although both normalized CSID and % creak detected task-dependent performance as a distinguishing feature of ADLD, a CSID profile wherein (a) the voiceless sentence
z
score was less severe than the voiced sentence and (b) the normalized voiceless sentence
z
score was within approximately 2
SD
s (or less) of typical expectations provided the best estimates of diagnostic precision. Automated acoustic measures such as the CSID and creak provide useful information to objectively discriminate ADLD and pMTD.
Getting Serious About Games: Exploring How Game-Based Learning Is Used in Education and Therapy
Authors: Springle Alisha P. 
Published: September 2024

Purpose:
The increasing interest in game-based learning (GBL) provides an opportunity to enhance interprofessional collaboration between speech-language pathologists (SLPs) and teachers. The purpose of this two-part article is to determine the similarities and differences between how teachers and SLPs think about and employ GBL.

Method:
Two distinct methods were used to research GBL. First, a systematic literature review gathered information on teachers' perspectives on GBL, including the benefits and implementation challenges. The important features of the learning games were also catalogued. Then, a qualitative study of focus groups containing both SLPs and teachers examined the shared and disparate views of GBL.

Results:
The initial literature review identified potential shared viewpoints of GBL as a motivational activity with a focus on learning and potential differences in implementation, use of professional time, and balancing fun and learning. The findings of the qualitative study validated that although teachers and SLPs share specific thoughts on GBL, their different patterns of use drive different paths for game selection and development.

Conclusions:
The similarities and differences between how teachers think about and use GBL are reviewed, and clinical implications are discussed. As with many interprofessional issues, GBL can be supported by collaborative practices that allow professionals to share their time and experiences while acknowledging and valuing their different expertise.
Probabilistic coupled EV‐PV hosting capacity analysis in LV networks with spatio‐temporal modelling and copula theory
Authors: Wanninayaka Mudiyanselage Chathuranga D. W. , Hasan Kazi N. , Vahidnia Arash , Rahman Mir Toufikur 
Published: September 2024

AbstractThe authors present an innovative approach for probabilistic coupled electric vehicle (EV) and solar photovoltaics (PV) hosting capacity analysis in low‐voltage (LV) distribution networks. The challenges posed by system uncertainties and correlations between different parameters, such as PV generation and EV charging demand, are addressed using probabilistic modelling. To appropriately incorporate the geographical distribution and time‐variant patterns of EV charging demand, a comprehensive spatio‐temporal (ST) model is developed to capture the trip distance, EV arrival, and charging time. The correlation between the PV generation and EV charging demand is effectively captured by copula theory. The proposed models have been validated using actual EV charging and PV generation data from 36 Australian EV users over 1 year. Power flow simulation with actual data and modelled data have identified EV‐only and coupled EV‐PV hosting capacities in an Australian LV test network. The coupled EV‐PV model presents a higher level of accuracy, having an average mean absolute percentage error (MAPE) of 5.97% compared to independent EV profiles having a MAPE of 10.12%. A voltage profile analysis with the EV and PV profiles also validates the same trend, having MAPE of 1.5% and 1.95%, respectively, for coupled EV‐PV and independent EV profiles.
Machine learning based fault detection technique for hybrid multi level inverter topology
Authors: Chappa Anilkumar , Rao K. Dhananjay , Dhananjaya Mudadla , Dawn Subhojit , Al Mansur Ahmed , Ustun Taha Selim 
Published: September 2024

AbstractMultilevel inverters (MLIs) have a significant contribution in many industrial sectors due to their improved power quality and lesser voltage stress, over the conventional three‐level inverters. However, the implementation of MLIs with an increased device count creates the scope of development in MLIs topologies. In this regard, a hybrid MLI topology is studied in this paper whose architecture is based on conventional two‐level inverters. This topology has lesser device count characteristics when compared to conventional and most of the recently presented configurations for nine‐level output voltage generation. The major issue of capacitor voltage balancing is resolved by employing an appropriate switching strategy. However, the semiconductor switches are the most vulnerable components and causes the open circuit faults frequently that creates issues in real time operation. Hence, it is important to detect the open circuit fault in switches in the least possible time. A new approach to open circuit fault detection technique based on the analysis of load voltage waveform is proposed in this paper. The wavelet transform technique has been implemented for feature extraction of load voltage. Later, the classification of the fault has been achieved by training an artificial neural network (ANN). The proposed work has been studied in MATLAB/simulation and the obtained results are verified experimentally.
Channel state information based physical layer authentication for Wi‐Fi sensing systems using deep learning in Internet of things networks
Authors: Roopak Monika , Ran Yachao , Chen Xiaotian , Tian Gui Yun , Parkinson Simon 
Published: September 2024

AbstractSecurity problems loom big in the fast‐growing world of Internet of Things (IoT) networks, which is characterised by unprecedented interconnectedness and data‐driven innovation, due to the inherent susceptibility of wireless infrastructure. One of the most pressing concerns is user authentication, which was originally intended to prevent unwanted access to critical information but has since expanded to provide tailored service customisation. We suggest a Wi‐Fi sensing‐based physical layer authentication method for IoT networks to solve this problem. Our proposed method makes use of raw channel state information (CSI) data from Wi‐Fi signals to create a hybrid deep‐learning model that combines convolutional neural networks and long short‐term memory networks. Rigorous testing yields an astonishing 99.97% accuracy rate, demonstrating the effectiveness of our CSI‐based verification. This technology not only strengthens wireless network security but also prioritises efficiency and portability. The findings highlight the practicality of our proposed CSI‐based physical layer authentication, which provides lightweight and precise protection for wireless networks in the IoT.
Improved Crouzeix-Raviart scheme for the Stokes and Navier-Stokes problem
Authors: Chénier Eric , Jamelot Erell , Le Potier Christophe , Peitavy Andrew 
Published: September 2024

The resolution of the incompressible Navier-Stokes equations is tricky, and it is well known that one of the major issue is to approach the space:

H1(Ω)∩ H(div 0; Ω) := {v ∈ H1(Ω) : div v = 0}.

The non-conforming Crouzeix-Raviart finite element are convenient since they induce local mass conservation. Moreover they are such that the stability constant of the Fortin operator is equal to 1. This implies that they can easily handle anisotropic mesh. However spurious velocities may appear and damage the approximation.
We propose a scheme here that allows one to reduce the spurious velocities. It is based on a new discretisation for the gradient of pressure based on the symmetric MPFA scheme (finite volume MultiPoint Flux Approximation).
Significant incidents during X-ray exposures in humans – assessment and findings of the Federal Office for Radiation Protection
Authors: Winter Katharina Stella , Schweden Monika , Brix Gunnar , Mille Erik 
Published: September 2024

AbstractIn Germany, significant incidents must be reported to the competent authority since 12/31/2018 (section 108 Radiation Protection Ordinance (StrlSchV)). After assessment and evaluation of the reports, the competent authority submits the relevant information via a web-based reporting system (BeVoMed) to the Federal Office for Radiation Protection (BfS), which publishes the results derived therefrom. The present paper evaluates significant incidents related to X-ray exposures on humans.All reports on incidents in X-ray diagnostics and interventional radiology between 01/2019 and 10/2023, which were completed with detailed information until the reporting day (31/10/2023), were included. The following aspects were statistically evaluated: classification as an incident (section 1 subsection (22) StrlSchV), significance (section 108 StrSchV), classification to Annex 14 StrlSchV, assignment to the forms of care in the German healthcare system, and development of the reporting frequency over time. Furthermore, the content of the reports was systematically evaluated with regard to conspicuous clusters and typical problems.Until the reporting day, 383 reports (355 completed) were received. 252 reports (228 in X-ray diagnostics, 24 in interventional radiology) referred to significant incidents and were included in the detailed evaluation. Reporting frequency increased in X-ray diagnostics, whereas there was no trend in interventional radiology. Most of the significant incidents concerned examinations on an individual person (category I, criterion 2a or category II, criteria 2a and 3a) in the in-patient sector – especially in maximum care hospitals. Frequent errors concerned the inappropriate choice of parameters/protocols or were related to the administration of a contrast agent. Despite the overall positive trend, the establishment of awareness and error culture remains challenging.
Effect of Lower Limb Muscle Fatigue on Dynamic Balance Performance in
Healthy Young Adults: Role of Arm Movement
Authors: Borgmann Katharina , Brinkmann Ruben , Bauer Julian , Hill Mathew W. , Muehlbauer Thomas 
Published: September 2024

AbstractThere is evidence that balance performance deteriorates due to exercise-induced
muscle fatigue. However, it is unknown if free arm movement during balance
testing can compensate for, or restricted arm movement can amplify these
performance degradations. Thus, the objective of this study was to compare the
effects of free versus restricted arm movement on balance performance under
non-fatigued and fatigued conditions. Fifty-two healthy participants (men=31,
women=21; age=22.6±1.6 years) were assessed for their dynamic balance (reach
distances for the Y Balance Test – Lower Quarter) under non-fatigued and
fatigued (repetitive vertical bipedal box jumps until failure) conditions using
two different arm positions: free (move the arms freely) and restricted (keep
the arms akimbo) arm movement. Restriction of arm movement (all
p<0.001; 0.48≤η
p
2≤0.79) and application
of fatigue (p≤0.003; 0.16≤η
p
2≤0.28)
independently, but not the interaction between the two (except for the
posteromedial reach direction: p=0.046;
η
p
2=0.08), resulted in significantly
deteriorated lower limb reach distances. These findings suggest that free arm
movement and thus the use of an ‘upper body strategy’ has no compensatory effect
on muscle fatigue-induced balance deteriorations.
Ein äußerst seltener Fall von multiplen Rezidiven eines Urothelzellkarzinoms in einer ilealen Neoblase: Fallbericht und Literaturübersicht
Authors: Clauser Silvia , Palermo Margherita , Palermo Salvatore , Comploj Evi , Hanspeter Esther , Mian Christine , Trenti Emanuela , Krüger Sara , Krause Philipp , Mazzucato Giovanni , Pycha Armin 
Published: September 2024

Zusammenfassung
In bis zu 18% tritt nach kurativer radikaler Zystektomie wegen eines Urothelkarzinoms ein Rezidiv auf. Zumeist manifestieren sich die Rezidive in den regionären Lymphknoten oder im verbliebenen oberen oder unteren Harntrakt. Extrem selten tritt ein Rezidiv in einer Neoblase auf, zumal es sich um ein anderes embryonales Keimblatt handelt.

Wir berichten über einen Fall, bei dem 10 Jahre nach der Zystoprostatektomie multiple Urothelkarzinomrezidive nur in der Neoblase auftraten. Daraufhin wurde die Neoblase entfernt und ein Sigma-Conduit angelegt. Trotzdem trat 6 Monate später eine generalisierte Metastasierung auf, woran der Patient wenig später verstarb. Zurzeit gibt es aufgrund der Seltenheit dieses Krankheitsbilds keine Behandlungsrichtlinien. Wir schildern unsere Erfahrungen und geben eine Literaturübersicht.