bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty-acid-binding protein inhibition produces analgesic effects through peripheral and central mechanisms
Authors: Peng Xiaoxue , Studholme Keith , Kanjiya Martha P , Luk Jennifer , Bogdan Diane , Elmes Matthew W , Carbonetti Gregory , Tong Simon , Gary Teng Yu-Han , Rizzo Robert C , Li Huilin , Deutsch Dale G , Ojima Iwao , Rebecchi Mario J , Puopolo Michelino , Kaczocha Martin 
Published: March 2017

Background Fatty-acid-binding proteins (FABPs) are intracellular carriers for endocannabinoids, N-acylethanolamines, and related lipids. Previous work indicates that systemically administered FABP5 inhibitors produce analgesia in models of inflammatory pain. It is currently not known whether FABP inhibitors exert their effects through peripheral or central mechanisms. Here, we examined FABP5 distribution in dorsal root ganglia and spinal cord and examined the analgesic effects of peripherally and centrally administered FABP5 inhibitors. Results Immunofluorescence revealed robust expression of FABP5 in lumbar dorsal root ganglia. FABP5 was distributed in peptidergic calcitonin gene-related peptide-expressing dorsal root ganglia and non-peptidergic isolectin B4-expressing dorsal root ganglia. In addition, the majority of dorsal root ganglia expressing FABP5 also expressed transient receptor potential vanilloid 1 (TRPV1) and peripherin, a marker of nociceptive fibers. Intraplantar administration of FABP5 inhibitors reduced thermal and mechanical hyperalgesia in the complete Freund’s adjuvant model of chronic inflammatory pain. In contrast to its robust expression in dorsal root ganglia, FABP5 was sparsely distributed in the lumbar spinal cord and intrathecal administration of FABP inhibitor did not confer analgesic effects. Administration of FABP inhibitor via the intracerebroventricular (i.c.v.) route reduced thermal hyperalgesia. Antagonists of peroxisome proliferator-activated receptor alpha blocked the analgesic effects of peripherally and i.c.v. administered FABP inhibitor while antagonism of cannabinoid receptor 1 blocked the effects of peripheral FABP inhibition and a TRPV1 antagonist blocked the effects of i.c.v. administered inhibitor. Although FABP5 and TRPV1 were co-expressed in the periaqueductal gray region of the brain, which is known to modulate pain, knockdown of FABP5 in the periaqueductal gray using adeno-associated viruses and pharmacological FABP5 inhibition did not produce analgesic effects. Conclusions This study demonstrates that FABP5 is highly expressed in nociceptive dorsal root ganglia neurons and FABP inhibitors exert peripheral and supraspinal analgesic effects. This indicates that peripherally restricted FABP inhibitors may serve as a new class of analgesic and anti-inflammatory agents.
High sensitivity cardiac troponins: Can they help in diagnosing myocardial ischaemia?
Authors: Orsini Enrico , Caravelli Paolo , Dini Frank Lloyd , Marzilli Mario 
Published: March 2017

Background: Cardiac troponin is the most sensitive marker of myocardial injury, but controversy still exists about its role in detecting ischaemia. Methods: To investigate the role of troponin as a marker of stress-induced ischaemia, circulating high sensitivity cardiac troponin T (hs-cTnT) was measured and compared with the MB fraction of creatine kinase (CK-MB) in 125 patients undergoing a stress test (53 electrocardiogram/echo exercise, 42 echo dipyridamole and 30 echo dobutamine tests). Results: Plasma concentrations of hs-cTnT increased after the tests in 90/125 patients, while an increase of CK-MB was seen in 31/125 patients ( p<0.0001). Overall, hs-cTnT significantly increased from 17.5±16.9 ng/l to 25.5±27.9 ng/l ( p<0.0001), without significant changes of CK-MB. Significant increments in hs-cTnT were documented after exercise test (from 15.9±11.9 ng/l to 19.5±13.6 ng/l, p<0.0001) and dobutamine test (from 20.6±20.8 ng/l to 37.8±31.1 ng/l, p=0.0006), in absence of changes in CK-MB according to each stressor. Among the 125 tests, 84 were diagnosed as negative and 41 as positive for myocardial ischaemia. Significant increments in hs-cTnT were detected after both negative (from 18.6±19.2 ng/l to 27.1±32.1 ng/l, p=0.0018) and positive test (from 15.2±10.8 ng/l to 22.3±16.2 ng/l, p=0.0005), without significant changes of CK-MB according to the test result. Despite a positive correlation between stress-induced increase of hs-cTnT and obstructive coronary artery disease, the release of troponin was observed also in a significant proportion of patients without coronary stenoses. Left ventricular hypertrophy markedly enhanced myocardial release of troponin. Conclusions: Circulating troponin increases in most patients undergoing a stress test, irrespective of the test result and of coronary artery disease. Plasma release of troponin depends on multiple pathogenetic mechanisms, making the biomarker a not reliable tool in detecting transient ischaemia.
Mizoroki–Heck Cross-Coupling Reaction of Haloarenes Mediated by a Well-Controlled Modified Polyacrylamide Brush Grafted Silica/Pd Nanoparticle System
Authors: Ghasemi Soheila , Karim Saiede 
Published: March 2017

Abstract
Modified polyacrylamide brushes including phosphinite functionality grafted onto silica supported Pd nanoparticles were synthesized via RAFT polymerization technique in a controlled manner with elucidated graft density and chain length. Proper activity of the catalyst was indicated in the Mizoroki–Heck coupling reaction of various haloarenes with olefins. Different aryl iodides with electron rich and electron deficient substituent and also ortho and heterocyclic substrate showed good reactivity to generate the corresponding coupled products in good to excellent yields using low Pd loading. The turnover number (TON) for this catalyst can be reduced up to 9.5 × 103. Simple filtration, appropriate reusability and negligible palladium leaching of this catalyst are among other advantages.
Managerial Compensation in Multidivision Firms
Authors: Alok Shashwat , Gopalan Radhakrishnan 
Published: March 2017

Using hand-collected data on division manager (DM) pay contracts, we document that DM pay is related to the performance of both the DM’s division and the other divisions in the firm. There is substantial heterogeneity in DM pay for performance. DM pay for division performance is lower in industries with less informative accounting earnings. DM pay is more sensitive to other-division performance if the DM’s division is related to the rest of the firm, if the DM’s division has fewer growth opportunities, and if the DM’s division receives less capital from the rest of the firm. Consistent with optimal contracting view, DMs receive greater pay for other-division performance in better-governed firms. Overall, our evidence suggests that DM compensation is structured to account for the information and agency problems in multidivision firms. The Internet appendix is available at https://doi.org/10.1287/mnsc.2016.2672 . This paper was accepted by Amit Seru, finance.
Adaptive Routing and Recharging Policies for Electric Vehicles
Authors: Sweda Timothy M. , Dolinskaya Irina S. , Klabjan Diego 
Published: March 2017

Planning a trip with an electric vehicle requires consideration of both battery dynamics and the availability of charging infrastructure. Recharging costs for an electric vehicle, which increase as the battery’s charge level increases, are fundamentally different than refueling costs for conventional vehicles, which do not depend on the amount of fuel already in the tank. Furthermore, the viability of any route requiring recharging is sensitive to the availability of charging stations along the way. In this paper, we study the problem of finding an optimal adaptive routing and recharging policy for an electric vehicle in a network. Each node in the network represents a charging station and has an associated probability of being available at any point in time or occupied by another vehicle. We develop efficient algorithms for finding an optimal a priori routing and recharging policy and then present solution approaches to an adaptive problem that build on a priori policy. We present two heuristic methods for finding adaptive policies—one with adaptive recharging decisions only and another with both adaptive routing and recharging decisions. We then further enhance our solution approaches to a special case of the grid network. We conduct numerical experiments to demonstrate the empirical performance of our solutions and provide insights to our findings. The online appendix is available at https://doi.org/10.1287/trsc.2016.0724 .
Analysis of the relations between allergen specific LgG antibody and allergic dermatosis of 14 kinds foods
Authors: Yin’e Hu , Shufang Dai , Bin Wang , Wei Qu , Junling Gao , Aqeel Ashraf Muhammad 
Published: March 2017

Abstract
To use food-specific IgG antibody detection to explore its application in the allergy dermatoses. 181 patients were included from January 2014 to September 2014. Fourteen food-specific IgG antibodies were detected by ELISA. The positive rates of IgG antibody of the patient group and the healthy group were significantly different. The positive rates of IgG antibody of egg, milk, shrimp and crab took a large proportion in three groups of patients with three kinds of allergy dermatoses of urticaria, eczema and allergic dermatitis, the proportion of which was respectively 70.2%, 77.8% and 71.7%. There was mild and moderate intolerance of food in the allergic dermatitis group while there was no distribution difference of food intolerance in urticaria group and eczema group. Among urticaria and allergic dermatitis patients with positive antibody, the positive rate of children was significantly higher than that of adults while there was no significant difference between children and adults among eczema patients with positive antibody. Allergy dermatoses are closely related to food-specific IgG antibody and the allergy dermatoses patients have a high incidence rate of food intolerance; detecting IgG antibody in patients is of great significance for the diagnosis and treatment of allergy dermatoses.
Artifacts reduction in strain maps of tagged magnetic resonance imaging using harmonic phase
Authors: Wang Daolei , Fu YaBo , Aqeel Ashraf Muhammad 
Published: March 2017

Abstract
Tagged Magnetic Resonance Imaging (MRI) is a noninvasive technique for examining myocardial function and deformation. Tagged MRI can also be used in quasistatic MR elastography to acquire strain maps of other biological soft tissues. Harmonic phase (HARP) provides automatic and rapid analysis of tagged MR images for the quantification and visualization of myocardial strain. We propose a new artifact reduction method in strain maps. Image intensity of the DC component is estimated and subtracted from spatial modulation of magnetization (SPAMM) tagged MR images. DC peak interference in harmonic phase extraction is greatly reduced after DC component subtraction. The proposed method is validated using both simulated and MR acquired tagged images. Strain maps are obtained with better accuracy and smoothness after DC component subtraction.
Study on correlation between bone marrow edema, stage of necrosis and area ratio of necrosis with the hip pain grading in nontraumatic osteonecrosis of the femoral head
Authors: Jianchuan Wang , Lei Yang , Benjie Wang , Dewei Zhao 
Published: March 2017

Abstract
The objective of this study was to explore the correlation between bone marrow edema, stage of necrosis, and area ratio of necrosis with the hip pain grading in non-traumatic osteonecrosis of the femoral head. Bone marrow edema grading at all levels and the hip pain grade differences were statistically significant (P < 0.001). Bone marrow edema grading increased by levels of 0, 1, and 2, whereas average pain rating increased as well to 40.73, 104.66 and 143.49. I ~ III period stage of necrosis and the hip pain grade difference was statistically significant (P < 0.001), with the average grade progress pain stage by the death of a rank gradually increased, I period, II period, III period was 57.00, 88.58 and 120.62, respectively. Area ratio of necrosis between 0 ~ 3 were positively correlated with pain, compared the two was statistically significant (P < 0.001), and with the degree of pathological changes is aggravating, increase the average rank of levels of pain. 0, 1, 2 and 3 are 36.88, 98.03, 123.87 and 151.93 respectively. We can choose the treatment method and evaluate treatment effect by considering a patients’ degree of bone marrow edema, stage of necrosis and area ratio of necrosis.
Study of the Correlation between the Level of CRP and Chemerin of Serum and the Occurrence and Development of DN
Authors: Wang Yunqian , Wang Min , Chen Baoping , Shi Jun 
Published: March 2017

Abstract
The aim of the study was to find the correlation between CRP and chemerin in development of DN. We choose 90 type-2 diabetic patients between February 2010 and February 2013, who were then divided into DN group and healthy control group. The results of BP showed that there is no difference in SBP and DBP of patients in the three groups. HDL-C of patients in diabetic group and DN group is lower compared with control. CRP in diabetic group and DN group is higher than that of patients in control group. Comparing the patients in DN group with that in diabeteic group, CRP was significantly higher. Chemerin level in the diabetic group and DN group is higher than control group. When comparing the patients in DN group with those in diabeteic group, serum level of chemerin was significantly higher. Serum level of chemerin is negatively correlated with HDL-C and positively correlated with FPG, HbA1c, LDL-C, BUN and Scr. Serum CRP is negatively correlated with HDL-C and positively correlated with FPG, HbA1c, LDL-C, BUN and Scr. Serum level of chemerin is positively correlated with CRP (r=0.701, P<0.05). CRP and chemerin of the DN patients rose significantly, and may participate in the occurrence and development of DN.
Quaternary ammonium salt of chitosan: preparation and antimicrobial property for paper
Authors: Liu Pengtao , Meng Weisheng , Wang Shuai , Sun Yonghui , Aqeel Ashraf Muhammad 
Published: March 2017

Abstract
A series of 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) was prepared by the reaction of chitosan with glycidyl trimethyl ammonium chloride. Structure of HACC was characterized by FT IR and 1H NMR spectroscopies, and it was proved that substitution reaction mainly occurs on the N element. Antimicrobial activities of HACC was examined against S. aureus, E. coli, and A. niger. Results indicatd that the inhibitory effects of HACC solutions were varied with HACC concentration, quaternization degrees, pH values, metal ions, and heat treatment. The antimicrobial properties of handsheets prepared from HACC were studied by the inhibition zone method, and the sheets had good antimicrobial properties against S. aureus and E. coli, and low inhibition rate against A. niger.
A case of Multiple Unilateral Pulmonary arteriovenous Malformation Relapse: Efficacy of embolization treatment
Authors: Masiello Rossella , Iadevaia Carlo , Grella Edoardo , Tranfa Carmelindo , Cerqua Francesco , Rossi Giovanni , Santoro Giuseppe , Amato Bruno , Rocca Aldo , De Dona Roberta , Lavoretano Sabrina , Perrotta Fabio 
Published: March 2017

Abstract
Pulmonary arteriovenous Malformations (PAVMs) are a rare vascular alteration characterized by abnormal communications between the pulmonary arteries and veins resulting in an extracardiac right-to-left (R-L) shunt. The majority of PAVMs are associated with an autosomal dominant vascular disorder also known as Osler-Weber- Rendu Syndrome. PAVMs appearance can be both single and multiple. Clinical manifestations include hypoxemia, dyspnea cyanosis, hemoptysis and cerebrovascular ischemic events or abscesses. We report a case of an 18 year old female with severe respiratory failure caused by a relapse of multiple unilateral pulmonary arterovenous fistula. Symptoms at admission include dyspnea, cyanosis and clubbing. The patient underwent pulmonary angio-TC scan, brain CT and echocardiography. The thoracic angio-CT scan showed the presence of PAVMs of RUL and RLL; a marked increase of right bronchial artery caliber and its branches with an aneurismatic dilatation was also observed. The patient underwent percutaneous transcatheter embolization using Amplatzer Vascular Plug IV; a relevant clinical and functional improvement was subsequently recorded. Embolization is effective in the treatment of relapsing PAVMS.
Changes in the coelomic microclimate during carbon dioxide laparoscopy: morphological and functional implications
Authors: Wilson Robert B. 
Published: March 2017

AbstractIn this article the adverse effects of laparoscopic CO2pneumoperitoneum and coelomic climate change, and their potential prevention by warmed, humidified carbon dioxide insufflation are reviewed. The use of pressurized cold, dry carbon dioxide (C02) pneumoperitoneum causes a number of local effects on the peritoneal mesothelium, as well as systemic effects. These can be observed at a macroscopic, microscopic, cellular and metabolic level. Local effects include evaporative cooling, oxidative stress, desiccation of mesothelium, disruption of mesothelial cell junctions and glycocalyx, diminished scavenging of reactive oxygen species, decreased peritoneal blood flow, peritoneal acidosis, peritoneal hypoxia or necrosis, exposure of the basal lamina and extracellular matrix, lymphocyte infiltration, and generation of peritoneal cytokines such as IL-1, IL-6, IL-8 and TNFα. Such damage is increased by high CO2insufflation pressures and gas velocities and prolonged laparoscopic procedures. The resulting disruption of the glycocalyx, mesothelial cell barrier and exposure of the extracellular matrix creates a cascade of immunological and pro-inflammatory events and favours tumour cell implantation. Systemic effects include cardiopulmonary and respiratory changes, hypothermia and acidosis. Such coelomic climate change can be prevented by the use of lower insufflation pressures and preconditioned warm humidified CO2. By achieving a more physiological temperature, pressure and humidity, the coelomic microenvironment can be better preserved during pneumoperitoneum. This has the potential clinical benefits of maintaining isothermia and perfusion, reducing postoperative pain, preventing adhesions and inhibiting cancer cell implantation in laparoscopic surgery.
Physical and Chemical Properties of Surface Waters in the Różany Strumień Catchment in The Years 1988–2012
Authors: Okońska Monika , Pietrewicz Katarzyna 
Published: March 2017

Abstract
The Różany Strumień catchment located in the north of Poznań is an example of a small anthropogenically-induced catchment. The main aim of this study is to analyse the variability of selected physical and chemical properties of surface waters in the catchment area in the years 1988-2012. It was found that surface waters in the catchment can be classified as hard and very hard, with slightly basic pH. The deterioration of Różany Strumień water quality concerns chemical oxygen demand, conductivity, chlorides, sodium, ammonia nitrogen and nitrite nitrogen concentrations. The authors of the study have noticed a decrease in the amount of phosphates and sulphates in the water. As observed, the hydrogeochemical type of water changed from calcium-hydrogen carbonate-sulphate into calcium-sodium-hydrogen carbonate-sulphate-chloride. Changes in water chemistry are probably a result of anthropogenic impacts, and they can be associated with the transformation of land use in the catchment area, i.e. the ongoing urbanization of the area.
Mapping Spatial and Temporal Changes of Global Corporate Research and Development Activities by Conducting a Bibliometric Analysis
Authors: Csomós György 
Published: March 2017

Abstract
Corporate research and development (R&D) activities have long been highly concentrated in a handful of world cities. This is due to the fact that these cities (e.g., Tokyo, New York, London, and Paris) are home to the largest and most powerful transnational corporations and are globally important sites for innovative start-up firms that operate in the fastest growing industries. However, in tandem with the rapid technological changes of our age, corporate R&D activities have shifted towards newly emerging and now globally significant R&D centres, like San Jose, San Francisco, and Boston in the United States, and Beijing, Seoul, and Shenzhen in East Asia. In this paper, I will conduct a bibliometric analysis to define which cities are centres of corporate R&D activities, how different industries influence their performance, and what spatial tendencies characterise the period from 1980 to 2014. The bibliometric analysis is based upon an assumption that implies there is a close connection between the number of scientific articles published by a given firm and the volume of its R&D activity.
Results show that firms headquartered in Tokyo, New York, London, and Paris published the largest combined number of scientific articles in the period from 1980 to 2014, but that the growth rate of the annual output of scientific articles was much greater in Boston, San Jose, Beijing, and Seoul, as well as some Taiwanese cities. Furthermore, it can also be seen that those cities that have the largest number of articles; i.e., that can be considered as the most significant sites of corporate R&D in which firms operate in fast-growing industries, are primarily in the pharmaceutical and information technology industries. For these reasons, some mid-sized cities that are home to globally significant pharmaceutical or information technology firms are also top corporate R&D hubs.
Discussion of the “Hottest Year on Record” in Australia
Authors: Parker Albert , Ollier Clifford D. 
Published: March 2017

Abstract
The global temperature trends provided by the Australian Bureau of Meteorology are artificially exaggerated due to subjective and unidirectional adjustments of recorded values. The present paper aims to promote the use of the raw stations’ data corrected only for urban heat island formation. The longer temperature records of Australia exhibit significant oscillations with a strong quasi-60 years’ signature of downward phases 1880 to 1910, 1940 to 1970 and 2000 to present, and upwards phases 1910 to 1940 and 1970 to 2000. A longer oscillation with downward phase until 1910 and an upwards phase afterwards is also detected. The warming since 1910 occurred at a nearly constant rate. Over the full length of the long Australian records since the end of the 1800s, there is no sign of warming or increased occurrence of extreme events. The monthly highest and mean maximum temperatures do not exhibit any positive trend. The differences between monthly highest and lowest, or monthly mean maximum and mean minimum temperatures, are all reducing because of urban heat island formation.
Number 13 / Part I. Music. 3. Mad Scenes: A Warning against Overwhelming Passions
Authors: Marisi Rossella 
Published: March 2017

Abstract
This study focuses on mad scenes in poetry and musical theatre, stressing that, according to Aristotle’s theory on catharsis and the Affektenlehre, they had a pedagogical role on the audience. Some mad scenes by J.S. Bach, Handel and Mozart are briefly analyzed, highlighting their most relevant textual and musical characteristics.