bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pulmonary hypertension in stiff left atrial syndrome: pathogenesis and treatment in one
Authors: Maeder Micha T. , Nägele Reto , Rohner Philipp , Weilenmann Daniel 
Published: November 2017

AbstractWe present the rare case of a patient with pulmonary hypertension in the context of the stiff left atrial syndrome after extensive catheter ablation, a unique constellation characterized by high pulmonary artery and pulmonary artery wedge pressures due to left atrial dysfunction but normal left ventricular end‐diastolic pressure, normal mitral valve, and absence pulmonary vein stenosis. This patient was surprisingly oligosymptomatic, however, which may have been due to a persistent post‐puncture atrial septal defect, which may have allowed for controlled left atrial decompression, which is in line with the novel concept of the catheter‐based creation of an intracardiac shunt as a treatment for heart failure.
Organometallic Polymer Electrolyte Membrane Fuel Cell Bis‐Ligand Nickel(Ii) Complex of 1,5‐Di‐P‐Tolyl‐3,7‐Dipyridine‐1,5,3,7‐Diazadiphosphacyclo‐Octane Catalyst
Authors: Kadirov Marsil K. , Karasik Andrey A. , Nizameev Irek R. , Strelnik Igor D. , Kholin Kirill V. , Kadirov Danis M. , Ismaev Timur I. , Budnikova Yulia G. , Sinyashin Oleg G. 
Published: November 2017

AbstractA 1,4‐Diaza‐3.7‐diphosphacyclo‐otane organometallic bis‐ligand nickel(II) complex [Ni(PPy2Np‐Tol2)2]2+2.[BF4]− on Vulcan XC‐72 (C) functions as both the cathode and anode catalysts in polymer electrolyte membrane fuel cell (PEMFC). In a PEMFC using Ni(Py‐p‐Tol)/C at the anode and Pt/C at the cathode the power density is shown to reach 14.66 mW cm−2, which is the highest power density of the none‐noble organometallic analogs. Based on the data produced using independent physico‐chemical methods, the mechanisms of the hydrogen oxidation and oxygen reduction reactions (HOR and ORR) on the anode and cathode sides of PEMFC, respectively, are reported.
Environmental doses of perfluorooctanoic acid change the expression of genes in target tissues of common carp
Authors: Rotondo John Charles , Giari Luisa , Guerranti Cristiana , Tognon Mauro , Castaldelli Giuseppe , Fano Elisa Anna , Martini Fernanda 
Published: November 2017

Abstract

We aimed to evaluate the effects of environmental doses of perfluorooctanoic acid (PFOA) on bioconcentration and gene expression in common carp (Cyprinus carpio). Adult male and female carp were exposed to environmental (200 ng/L) and experimental (2 mg/L) doses of PFOA for 56 d. Carp exposed to 200 ng/L had levels of PFOA below the level of detection in all tissue samples analyzed, whereas variable concentrations were measurable in various tissues from carp exposed to 2 mg/L. The expression level of the glutathione S-transferase (GST) gene, coding for a detoxifying enzyme, increased in a PFOA dose-dependent manner in liver tissues from 200 ng/L to 2 mg/L exposure (p &lt; 0.05). The expression levels of CYP19A gene, coding for the enzyme that converts testosterone into estrogen, were altered in gonadal tissues from male and female carp exposed to either 200 ng/L or 2 mg/L; expression increased in male gonads and decreased in female gonads. Unexpectedly, the expression levels of CYP19A in male and female gonads from carp exposed to 200 ng/L or 2 mg/L were similar (p &gt; 0.05). Therefore, even though environmental doses of PFOA did not accumulate in tissues of the common carp, they did affect the gene expression levels of GST in the liver and CYP19A in the gonads. These observations raise concerns that exposure to environmental doses of PFOA may affect gene expression in animals and possibly in humans, with important health consequences. Environ Toxicol Chem 2018;37:942–948. © 2017 SETAC
An ancestry‐based approach for detecting interactions
Authors: Park Danny S. , Eskin Itamar , Kang Eun Yong , Gamazon Eric R. , Eng Celeste , Gignoux Christopher R. , Galanter Joshua M. , Burchard Esteban , Ye Chun J. , Aschard Hugues , Eskin Eleazar , Halperin Eran , Zaitlen Noah 
Published: November 2017

ABSTRACTBackgroundEpistasis and gene‐environment interactions are known to contribute significantly to variation of complex phenotypes in model organisms. However, their identification in human association studies remains challenging for myriad reasons. In the case of epistatic interactions, the large number of potential interacting sets of genes presents computational, multiple hypothesis correction, and other statistical power issues. In the case of gene‐environment interactions, the lack of consistently measured environmental covariates in most disease studies precludes searching for interactions and creates difficulties for replicating studies.ResultsIn this work, we develop a new statistical approach to address these issues that leverages genetic ancestry, defined as the proportion of ancestry derived from each ancestral population (e.g., the fraction of European/African ancestry in African Americans), in admixed populations. We applied our method to gene expression and methylation data from African American and Latino admixed individuals, respectively, identifying nine interactions that were significant at . We show that two of the interactions in methylation data replicate, and the remaining six are significantly enriched for low P‐values ().ConclusionWe show that genetic ancestry can be a useful proxy for unknown and unmeasured covariates in the search for interaction effects. These results have important implications for our understanding of the genetic architecture of complex traits.
Integrative sparse principal component analysis of gene expression data
Authors: Liu Mengque , Fan Xinyan , Fang Kuangnan , Zhang Qingzhao , Ma Shuangge 
Published: November 2017

ABSTRACTIn the analysis of gene expression data, dimension reduction techniques have been extensively adopted. The most popular one is perhaps the PCA (principal component analysis). To generate more reliable and more interpretable results, the SPCA (sparse PCA) technique has been developed. With the “small sample size, high dimensionality” characteristic of gene expression data, the analysis results generated from a single dataset are often unsatisfactory. Under contexts other than dimension reduction, integrative analysis techniques, which jointly analyze the raw data of multiple independent datasets, have been developed and shown to outperform “classic” meta‐analysis and other multidatasets techniques and single‐dataset analysis. In this study, we conduct integrative analysis by developing the iSPCA (integrative SPCA) method. iSPCA achieves the selection and estimation of sparse loadings using a group penalty. To take advantage of the similarity across datasets and generate more accurate results, we further impose contrasted penalties. Different penalties are proposed to accommodate different data conditions. Extensive simulations show that iSPCA outperforms the alternatives under a wide spectrum of settings. The analysis of breast cancer and pancreatic cancer data further shows iSPCA's satisfactory performance.
Ore genesis of the Xiadian gold deposit, Jiaodong Peninsula, East China: Information from fluid inclusions and mineralization
Authors: Liu Jianchao , Wang Jinya , Liu Yang , Tian Jingxiang , Li Xiuzhang , Zhang Haidong 
Published: November 2017

Orebodies in the Xiadian gold deposit in the Jiaodong Peninsula, China are mainly hosted in the Mesozoic granitoids, controlled structurally by the Zhaoyuan–Pingdu Fault Zone, and occur as disseminated and cataclastic altered type. Four mineralization stages were identified as follows: quartz–pyrite stage (I), gold‐bearing fine‐grained pyrite–quartz stage (II), polymetallic sulfide–quartz stage (III), and quartz–carbonate stage (IV). Quartz was classified as including quartz granules with dentation boundaries (I), cataclastic quartz grain assemblages (II and III), and rod‐like quartz grains (IV). Petrography, laser Raman analysis, and microthermometry of fluid inclusions in these stages (in both tunnel and borehole samples) reveal (a) CO2–H2O fluid inclusions (C–H type), (b) CO2–H2O ± CH4fluid inclusions (C–H–CH4type), and (c) aqueous fluid inclusions (H type). Fluid immiscibility caused by fluid mixing caused rapid precipitation of gold. The ore‐forming fluid of the Xiadian gold deposit evolves from an H2O–CO2–NaCl ± CH4system with medium temperature and salinity to an H2O–NaCl system with low temperature and salinity, from CO2‐rich to CO2‐poor in composition and from a mixture of magmatic water with increasing meteoric water as δ18OH2Ovalues. Sulphur isotope compositions suggest a mixed source of ore metal, and the Jiaodong Group may be a major source for sulphur. Fluid parameters of borehole samples indicate that there is the same fluid system for Au precipitation at different depths and fault gouge with poor permeability may play a crucial role in forming a relatively closed semi‐open space for Au precipitation. Integrating the data obtained from the studies including regional geology, ore geology, and fluid inclusions and stable isotope geochemistry, the Xiadian gold deposit is concluded as an orogenic‐type gold deposit formed in the tectonic transition from compression to extension.
Association of interleukin‐18 gene polymorphism and its protein expression with the lower extremity deep venous thrombosis in the chinese han population: A case‐control study
Authors: Chen Ye‐Long , Shou Li‐Hong , Zhang Zong‐Xin 
Published: November 2017

ObjectiveWe aim to explain the correlation among IL‐18 gene polymorphism, its protein expression and LEDVT in the Chinese Han population.MethodsA total of 138 LEDVT patients and 150 healthy people volunteered as LEDVT and control groups. All the data, including the gender, age, BMI, levels of TG, LDL/HDL, TC, GLU, APTT, BUN, Cr, ALT, AST, ApoA1, ApoB, and Fg was detected. IL‐18 level, IL‐18 −137G/C and −607C/A polymorphism, and risk factors of LEDVT were detected using ELISA, PCR‐RFLP and multivariate logistic regression analysis, respectively.ResultsIncreased BMI, GLU, Fg, BUN, ApoB and IL‐18 and decreased APTT were found in the LEDVT group. The GC + CC genotype and C allele in −137G/C polymorphism was elevated in the control group when compared to that in the LEDVT group. The IL‐18 level was elevated in the case group when compared to the control group with respect to the same genotype in −607C/A and −137G/C polymorphisms, and in the LEDVT group, IL‐18 level was higher in the GG genotype than that in the GC + CC genotype of −137G/C polymorphism. BUN, GG genotype and IL‐18 level were independent risk factors, but APTT was a protective factor of LEDVT.ConclusionOn the basis of our results, we concluded that the GG genotype of −137G/C polymorphism and IL‐18 level are independent risk factors of LEDVT, and IL‐18 gene polymorphism affects the level of IL‐18 in LEDVT patients.
Late‐onset type I endoleak characterized by contrast enhanced ultrasound after endovascular repair of aortic aneurysm
Authors: Gifford John Nathan , Cheong Hsueh Wen , Teoh Wey Chyi 
Published: November 2017

AbstractWe report in the case of a patient with an intra‐abdominal aortic aneurysm treated with endovascular aneurysm repair (EVAR) who developed renal impairment during the period of follow up. The repair was complicated with an early‐onset type II endoleak which later evolved into a late‐onset type I endoleak. It was treated with proximal extension of stent graft, with treatment success and follow‐up documented on contrast enhanced ultrasound (CEUS). This case illustrates the usefulness of CEUS in post‐EVAR surveillance and emphasizes the need for life‐long monitoring as late‐onset complications are not uncommon.
Sonographically guided insertion of intrauterine device: Indications and results
Authors: Balica Adrian C. , Kim Chi‐Son , Egan Susan , Ayers Charletta A. , Bachmann Gloria A. 
Published: November 2017

AbstractFrom 2011 to 2015, a total of 67 patients were referred for IUD insertion guided with transabdominal sonography (TAS). Fifty‐six of the 67 patients had successful IUD insertion under TAS guidance. The clinical indications for referral included fibroids, uterine position, previous history of IUD expulsion, and limited tolerance of pelvic examination. Reasons for failed TAS‐guided IUD insertion included patient discomfort, cervical stenosis, and inability to remove and replace an existing device. Ultrasound guidance could help broaden the patient population that may benefit from the therapeutic value of an IUD.
Multispecificity of a recombinant anti‐ras monoclonal antibody
Authors: Schrader John W. , McLean Gary R. 
Published: November 2017

AbstractRecombinant monoclonal antibodies (Ab's) have widespread application as research tools, diagnostic reagents and as biotherapeutics. Whilst studying the cellular molecular switch protein m‐ras, a recombinant monoclonal antibody to m‐ras was generated for use as a research tool. Antibody genes from a single rabbit B cell secreting IgG to an m‐ras specific peptide sequence were expressed in mammalian cells, and monoclonal rabbit IgG binding was characterized by ELISA and peptide array blotting. Although the monoclonal Ab was selected for specificity to m‐ras peptide, it also bound to both recombinant full‐length m‐ras and h‐ras proteins. The cross‐reactive binding of the monoclonal Ab to h‐ras was defined by peptide array blot revealing that the Ab showed preference for peptide sequences containing multiple positively charged amino acid residues. These data reinforce the concept of antibody multispecificity through multiple interactions of the Ab paratope with diverse polypeptides. They also emphasize the importance of immunogen and Ab selection processes when generating recombinant monoclonal Ab's.
In vitro screening and isolation of human aromatase inhibitors from Cicer arietinum by a novel continuous online method combining chromatographic techniques
Authors: Zhang Yuchi , He Yan , Liu Chengyu , Liu Chunming , Li Sainan 
Published: November 2017

AbstractUltrafiltration liquid chromatography with mass spectrometry can efficiently and rapidly screen and identify ligands from the seeds of Cicer arietinum for human aromatase. Using this method, we identified 11 major compounds, including organic acids, organic acid glycosides, flavone glycosides, isoflavones, and isoflavone glycosides, as potent human aromatase inhibitors. A continuous online method, including pressurized liquid extraction, countercurrent chromatography, and preparative liquid chromatography, was developed for scaling up the production of these compounds with high purity and efficiency. The bioactivity of the separated compounds was assessed by an in vitro enzyme inhibition assay. This novel approach using a combination of ultrafiltration liquid chromatography with mass spectrometry and pressurized liquid extraction with countercurrent chromatography and preparative liquid chromatography as well as an in vitro enzyme inhibition assay could be applied to efficiently screen and isolate human aromatase inhibitors from complex samples and to the large‐scale production of functional food and nutraceutical ingredients.
The Efficacy of Lavender Aromatherapy in Reducing Preoperative Anxiety in Ambulatory Surgery Patients Undergoing Procedures in General Otolaryngology
Authors: Wotman Michael , Levinger Joshua , Leung Lillian , Kallush Aron , Mauer Elizabeth , Kacker Ashutosh 
Published: November 2017

BackgroundPreoperative anxiety is a common problem in hospitals and other health care centers. This emotional state has been shown to negatively impact patient satisfaction and outcomes. Aromatherapy, the therapeutic use of essential oils extracted from aromatic plants, may offer a simple, low‐risk and cost‐effective method of managing preoperative anxiety. The purpose of this study was to evaluate the efficacy of lavender aromatherapy in reducing preoperative anxiety in ambulatory surgery patients undergoing procedures in general otolaryngology.MethodsA prospective and controlled pilot study was conducted with 100 patients who were admitted to New York‐Presbyterian/Weill Cornell Medical Center for ambulatory surgery from January of 2015 to August of 2015. The subjects were allocated to two groups; the experimental group received inhalation lavender aromatherapy in the preoperative waiting area while the control group received standard nursing care. Both groups reported their anxiety with a visual analog scale (VAS) upon arriving to the preoperative waiting area and upon departure to the operating room.ResultsAccording to a Welch's two sample t‐test, the mean reduction in anxiety was statistically greater in the experimental group than the control group (p = 0.001).ConclusionLavender aromatherapy reduced preoperative anxiety in ambulatory surgery patients. This effect was modest and possibly statistically significant. Future research is needed to confirm the clinical efficacy of lavender aromatherapy.Level of Evidence2b
Clinical efficacy of a topical lactic acid bacterial microbiome in chronic rhinosinusitis: A randomized controlled trial
Authors: Mårtensson Anders , Abolhalaj Milad , Lindstedt Malin , Mårtensson Anette , Olofsson Tobias C. , Vásquez Alejandra , Greiff Lennart , Cervin Anders 
Published: November 2017

ObjectiveA locally disturbed commensal microbiome might be an etiological factor in chronic rhinosinusitis (CRS) in general and in CRS without nasal polyps (CRSsNP) in particular. Lactic acid bacteria (LAB) have been suggested to restore commensal microbiomes. A honeybee LAB microbiome consisting of various lactobacilli and bifidobacteria have been found potent against CRS pathogens in vitro. Recently, we examined effects of single nasal administrations of this microbiome in healthy subjects and found it inert. In this study, we examined effects of repeated such administrations in patients with CRSsNP.Study DesignThe study was of a randomized, double‐blinded, crossover, and sham‐controlled design.MethodsTwenty patients received 2 weeks' treatment administered using a nasal spray‐device. The subjects were monitored with regard to symptoms (SNOT‐22 questionnaire, i.e., the primary efficacy variable), changes to their microbiome, and inflammatory products (IL‐6, IL‐8, TNF‐, IL‐8,a, and MPO) in nasal lavage fluids.ResultsNeither symptom scores, microbiological explorations, nor levels of inflammatory products in nasal lavage fluids were affected by LAB (c.f. sham).ConclusionTwo weeks' nasal administration of a honeybee LAB microbiome to patients with CRSsNP is well tolerated but affects neither symptom severity nor the microbiological flora/local inflammatory activity.Level of Evidence1b
Immunological Changes Induced in Peach Allergy Patients with Systemic Reactions by Pru p 3 Sublingual Immunotherapy
Authors: Palomares Francisca , Gomez Francisca , Bogas Gador , Campo Paloma , Perkins James Richard , Diaz‐Perales Araceli , Rodriguez Maria J. , Prieto Ana , Barber Domingo , Torres María J. , Mayorga Cristobalina 
Published: November 2017

ScopeSublingual immunotherapy using peach extract enriched in Pru p 3 (Pru p 3‐enriched‐SLIT) brings a new perspective to treating patients with allergy to lipid transfer proteins. We evaluate the immunological changes induced by Pru p 3‐enriched‐SLIT during one year.Methods and resultsThree groups are included: peach allergic patients who receive Pru p 3‐enriched‐SLIT, peach allergic untreated patients, and controls. Peripheral blood mononuclear cells are obtained before treatment and at different time‐points. Monocyte‐derived dendritic cells (moDCs) maturation and lymphocyte proliferation are assessed by flow cytometry. Data showed a significant reduction of moDCs maturation status during one year of treatment and an increase in PD‐L1. Moreover, we observed a significant decrease of the Pru p 3‐specific proliferation of effector cells and an increase in regulatory T (Treg) cells with higher PD‐L1 expression and IL‐10 production. These are observed in patients treated only.ConclusionSuccessful Pru p 3‐enriched‐SLIT is linked to an important immunosuppression of allergen‐specific effector T cells, potentially due to an increase of allergen‐specific Treg cells. These cellular changes are orchestrated by the activity of moDCs promoting the expression of PD‐L1 that will participate in the regulatory response. These changes may serve as biomarkers during SLIT alongside other features such as IgE/IgG4 ratio.
Implementation of dosimetry equipment and phantoms at the MedAustron light ion beam therapy facility
Authors: Grevillot Loïc , Stock Markus , Palmans Hugo , Osorio Moreno Jhonnatan , Letellier Virgile , Dreindl Ralf , Elia Alessio , Fuchs Hermann , Carlino Antonio , Vatnitsky Stanislav 
Published: November 2017

PurposeTo describe the implementation of dosimetry equipment and phantoms into clinical practice of light ion beam therapy facilities. This work covers not only standard dosimetry equipment such as computerized water scanners, films, 2D‐array, thimble, and plane parallel ionization chambers, but also dosimetry equipment specifically devoted to the pencil beam scanning delivery technique such as water columns, scintillating screens or multilayer ionization chambers.MethodAdvanced acceptance testing procedures developed at MedAustron and complementary to the standard acceptance procedures proposed by the manufacturer are presented. Detailed commissioning plans have been implemented for each piece of dosimetry equipment and include an estimate of the overall uncertainty budget for the range of clinical use of each device. Some standard dosimetry equipment used in many facilities was evaluated in detail: for instance, the recombination of a 2D‐array or the potential use of a microdiamond detector to measure reference transverse dose profiles in water in the core of the primary pencil beams and in the low‐dose nuclear halo (over four orders of magnitude in dose).ResultsThe implementation of dosimetry equipment as described in this work allowed determining absolute spot sizes and spot positions with an uncertainty better than 0.3 mm. Absolute ranges are determined with an uncertainty comprised of 0.2–0.6 mm, depending on the measured range and were reproduced with a maximum difference of 0.3 mm over a period of 12 months using three different devices.ConclusionThe detailed evaluation procedures of dosimetry equipment and phantoms proposed in this work could serve as a guidance for other medical physicists in ion beam therapy facilities and also in conventional radiation therapy.
Analysis for efficiency potential of high‐efficiency and next‐generation solar cells
Authors: Yamaguchi Masafumi , Lee Kan‐Hua , Araki Kenji , Kojima Nobuaki , Yamada Hiroyuki , Katsumata Yasuhiro 
Published: November 2017

AbstractThis paper overviews photovoltaic R&D projects in Japan. Recently, world‐record and second highest efficiencies of various types of solar cells have been demonstrated under the New Energy and Industrial Technology Development Organization Project: 44.4% (under concentration) and 37.9% (under 1 sun) InGaP/GaAs/InGaAs inverted metamorphic 3‐junction solar cells by Sharp, 26.7% single crystalline Si heterojunction back‐contact solar cell by Kaneka, 22.3% copper indium gallium selenide solar cell by Solar Frontier, a‐Si/μc‐Si/μc‐Si thin‐film triple‐junction solar cell with stabilized efficiency of 14.0% by AIST, 11.9% dye‐sensitized solar cell by Sharp, and 11.2% organic solar cell by Toshiba. This paper also presents efficiency potential of high‐efficiency and next‐generation solar cells analyzed by considering external radiative efficiency, open‐circuit voltage loss, and fill factor loss. Efficiency potential of crystalline Si, GaAs, III‐V compound 3‐junction and 5‐junction, CIGSe, CdTe, CZTS(Se), multiquantum well, and quantum dot and perovskite solar cells is shown to be 28.5%, 29.7%, 40%, 43%, 26.5%, 26.5%, 20%, 25.8%, and 24.9% under 1 sun, respectively.