bluuebunny/crossref_metadata_2025_split huggingface dataset:
Limb Salvage After Failed Initial Operative Management of Bimalleolar Ankle Fractures in Diabetic Neuropathy
Authors: Vaudreuil Nicholas J. , Fourman Mitchell S. , Wukich Dane K. 
Published: November 2016

Background: Ankle fractures in patients with diabetes mellitus (DM) can be difficult to manage, especially in the presence of peripheral neuropathy. In patients who fail initial operative management, attempts at limb salvage can be challenging, and no clear treatment algorithm exists. This study examined outcomes of different procedures performed for limb salvage in this population. Methods: This study retrospectively reviewed 17 patients with DM complicated by peripheral neuropathy who sustained a bimalleolar ankle fracture and failed initial operative management. Patients were treated with revision open reduction internal fixation (ORIF) (3/17), closed reduction external fixation (CREF) (8/17), or primary ankle joint fusion (3/17 tibiotalocalcaneal fusion with hindfoot nail [TTCN] and 3/17 with tibiotalar arthrodesis using plates and screws [TTA]). Median follow-up was 20 months. Results: The overall rate of limb salvage was 82.3% (14/17). All patients who went on to amputation presented with infection and were treated initially with CREF (3/3). All patients who achieved successful limb salvage ended up with a clinically fused ankle joint (14/14); 9 underwent a primary or delayed formal fusion and 5 had a clinically fused ankle joint at study conclusion after undergoing revision ORIF or CREF with adjunctive procedures. Conclusion: This small study suggests that in this complicated group of patients it is difficult to achieve limb salvage with an end result of a functional ankle joint. CREF can be a viable option in cases where underlying infection or poor bone quality is present. Treatment with revision ORIF frequently requires supplementary external fixator or tibiotalar Steinman pin placement for additional stability. All patients who underwent revision ORIF ended up with clinically fused ankle joints at the end of the study period. Primary fusion procedures (TTA, TTCN) were associated with a high rate of limb salvage and a decreased number of operations. Level of Evidence: Level III, retrospective case series.
A Nationwide Study of the Impact of Dysphagia on Hospital Outcomes Among Patients With Dementia
Authors: Paranji Suchitra , Paranji Neethi , Wright Scott , Chandra Shalini 
Published: November 2016

Objectives: To assess the impact of dysphagia on clinical and operational outcomes in hospitalized patients with dementia. Design: Retrospective cohort study. Setting: 2012 Nationwide Inpatient Sample. Participants: All patients discharged with a diagnosis of dementia (N = 234,006) from US hospitals in 2012. Measurements: Univariate and multivariate regression models, adjusting for stroke and patient characteristics, to assess the impact of dysphagia on the prevalence of comorbidities, including pneumonia, sepsis, and malnutrition; complications, including mechanical ventilation and death; and operational outcomes, including length of stay (LOS) and total charges for patients with dementia. Results: Patients having dementia with dysphagia (DWD) had significantly higher odds of having percutaneous endoscopic gastrostomy placement during the admission (odds ratio [OR]: 13.68, 95% confidence interval [CI]: 12.53-14.95, P < .001), aspiration pneumonia (OR: 6.27, 95% CI: 5.87-6.72, P < .001), pneumonia (OR: 2.84, 95% CI: 2.67-3.02, P < .001), malnutrition (OR: 2.5, 95% CI: 2.27-2.75, P < .001), mechanical ventilation (OR: 1.69, 95% CI: 1.51-1.9, P < .001), sepsis (OR: 1.52, 95% CI: 1.39-1.67, P < .001), and anorexia (OR: 1.29, 95% CI: 1.01-1.65, P = .04). Mean LOS was 2.16 days longer (95% CI: 1.98-2.35, P < .001), mean charge per case was US$10,703 higher (95% CI: US$9396-US$12,010, P < .001), and the odds of being discharged to a skilled nursing, rehabilitation, or long-term facility was 1.59 times higher (95% CI: 1.49-1.69, P < .001) in the DWD cohort compared to patients having dementia without dysphagia. Conclusion: Dysphagia is a significant predictor of worse clinical and operational outcomes including a 38% longer LOS and a 30% increase in charge per case among hospitalized patients with dementia. Although these findings may not be surprising, this new evidence might bring heightened awareness for the need to more thoughtfully support patients with dementia and dysphagia who are hospitalized.
Technical attributes of Australian youth soccer players: Implications for talent identification
Authors: Keller Brad S , Raynor Annette J , Bruce Lyndell , Iredale Fiona 
Published: November 2016

Objectives To determine whether the technical ability of Australian youth soccer players could distinguish between various playing levels. Design A cross-sectional observational design was used with each player required to complete four technical tests. Methods Sixty-two participants were representatives of three cohorts of youth soccer in Australia: national elite ( n = 18), state elite ( n = 22) and sub-elite ( n = 22). The technical tests used were Loughborough Short Passing Test (LSPT), long passing test (LPT), shooting test and speed dribbling, with all players familiarised with the tests prior to data collection. Differences between cohorts were analysed using a multiple analysis of variance test with follow-up analyses of variance and Tukey Honest Significant Difference post-hoc test, which were subsequently used to inform a sensitivity analysis, more specifically a bootstrapped receiver operating curve to determine cut-off scores for each variable. Results The national elite cohort scored better than state- and sub-elite cohorts on the LSPT, however, the state elite produced the fastest time before penalties. The sub-elite cohort scored less points on the LPT compared to both national- and state-elite cohorts, on both feet. In regards to speed dribbling, national-elite players were faster than both the state- and sub-elite cohorts. Shooting accuracy and velocity were able to discriminate the national- and sub-elite cohorts on the dominant foot, with shooting velocity on the nondominant foot being faster for the national elite compared to both the state- and sub-elite cohorts. Conclusions A number of differences in technical ability were identified between varying levels of Australian youth soccer players. Youth soccer coaches and sports scientists should use the cut-off scores for the technical tests in the talent identification and development process, with aspiring players aiming to reach these levels.
Bone Health in Athletes
Authors: Goolsby Marci A. , Boniquit Nicole 
Published: November 2016

Context: The health of the skeletal system is important for athletes young and old. From the early benefits of exercise on bones to the importance of osteoporosis prevention and treatment, bone health affects the ability to be active throughout life. Evidence Acquisition: PubMed articles dating from 1986 to 2016 were used for the review. Relevant terms such as keywords and section titles of the article were searched and articles identified were reviewed for relevance to this article. Study Design: Clinical review. Level of Evidence: Levels 1 through 4 evidence included. Results: There is strong evidence that exercise benefits bone health at every age and is a critical factor in osteoporosis prevention and treatment. Vitamin D, calcium, and hormones play vital roles in ensuring optimal bone health. When there is an imbalance between exercise and nutrition, as seen in the female athlete triad, bone health is compromised and can lead to bone stress injuries and early osteoporosis. Both of these can lead to morbidity and lost time from training and competition. Thus, early recognition and appropriate treatment of the female athlete triad and other stress fracture risk factors are vital to preventing long-term bone health problems. Conclusion: To optimize bone health, adequate nutrition, appropriate weightbearing exercise, strength training, and adequate calcium and vitamin D are necessary throughout life.
Postnatal regulation of MAMDC4 in the porcine intestinal epithelium is influenced by bacterial colonization
Authors: Pasternak Alex J. , Hamonic Glenn M. , Van Kessel Andrew , Wilson Heather L. 
Published: November 2016

AbstractThe MAM domain‐containing 4 (MAMDC4) protein is associated with the unique endocytotic mechanism observed in the intestine of mammals during the immediate postnatal period. Transcriptional expression of MAMDC4 was substantially upregulated at birth in both the piglet jejunum and ileum and its expression decreases after birth. The protein was found localized specifically to the apical region of the luminal epithelium, however, MAMDC4 protein expression was lost at day 10 and 15 in the jejunum and ileum, respectively, and was not associated with “fetal” enterocyte replacement. Although spatial variation in the subcellular localization of Claudin 1 (CLDN1) was noted at day 3, the loss of MAMDC4 at later stages of development did not appear to have any effect on the tight junction structure. Germ‐free (GF) piglets and piglets whose gastrointestinal flora consists exclusively of Escherichia coli (EC) or Lactobacillus fermentum (LF) maintained MAMDC4 protein expression to 14 days of age in distal regions of the small intestine whereas those with conventionalized intestinal flora (CV) showed no MAMDC4 protein at this age. MAMDC4 protein expression was most pronounced in the LF and GF colonized piglets which showed staining in the epithelial cells at 75% and 95% of the length of the small intestine, respectively, which matched that of the newborn. In contrast, EC animals showed only a low abundance at these regions as well as a discontinuous staining pattern. Collectively these results suggest that maturation of MAMDC4 expression in the porcine epithelium occurs more rapidly than what is reported in previously studied rodent species. Furthermore, intestinal bacterial colonization is a major regulator of MAMDC4 in a manner specific to bacterial species and independent of enterocyte turnover.
Influences of Resistance Training on Physical Function in Older, Obese Men and Women With Sarcopenia
Authors: Stoever Katja , Heber Anke , Eichberg Sabine , Brixius Klara 
Published: November 2016

Background and Purpose:
Sarcopenic obesity is associated with disability, gait problems, and falls. Activities of daily living such as walking and climbing stairs are physically difficult or impossible for the individual with severe obesity. These aspects also limit participation in recreational activities or exercise programs. However, good muscle function is crucial to maintain functional independence. The objective of this study was to investigate the influence of resistance training on physical function in older, obese persons with sarcopenia. The study was conducted in a pre-test/post-test design with 2 intervention groups.

Methods:
The participants were physically inactive and obese older adults (≥65 years, BMI ≥ 30 kg/m2), without severe diseases. They were divided into a group with sarcopenia (SAR, n = 28) and a group with no or presarcopenia (NSAR, n = 20). The intervention consisted of progressive resistance training, undertaken twice a week for 16 weeks, increasing to 80% to 85% of maximum strength with 3 sets of 8 to 12 repetitions. Sarcopenia was assessed using the Short Physical Performance Battery (SPPB), hand-grip strength, and skeletal muscle mass index (SMI). In addition, the modified Physical Performance Test (PPT) and the Functional Reach Test were used for determining physical function.

Results and Discussion:
After training, participants in the SAR group were able to significantly increase their performance in hand-grip strength (by 9%), gait speed (by 5%), SPPB score (by 13%), and modified PPT score (by 11%). In SPPB and modified PPT, they could reach the values of the NSAR group's baseline performance. The NSAR group participants were also able to improve their already good performance at baseline in the 2 tests of physical function after training (SPPB score by 10%, modified PPT score by 7%). However, the participants of both groups could not increase the results of the SMI and the Functional Reach Test.

Conclusions:
The participants of both groups improved their physical performance in several parameters after training. The results also showed that older, obese adults with sarcopenia benefitted from resistance training. The increase in muscle function can support them having a life with functional independence, and this can help reduce the risk of disability and falls.
Effect of Footwear on Joint Pain and Function in Older Adults With Lower Extremity Osteoarthritis
Authors: Wagner Amy , Luna Sarah 
Published: November 2016

Background and Purpose:
Lower extremity osteoarthritis (OA) is a common condition among older adults; given the risks of surgical and pharmaceutical interventions, conservative, lower-cost management options such as footwear warrant further investigation. This systematic review investigated the effects of footwear, including shoe inserts, in reducing lower extremity joint pain and improving gait, mobility, and quality of life in older adults with OA.

Methods:
The CINAHL, SPORTDiscus, PubMed, RECAL, and Web of Knowledge databases were searched for publications from January 1990 to September 2014, using the terms “footwear,” “shoes,” “gait,” “pain,” and “older adult.” Participants who were 50 years or older and those who had OA in at least one lower extremity joint narrowed the results. Outcomes of interest included measures of pain, comfort, function, gait, or quality of life. Exclusion criteria applied to participants with rheumatoid arthritis, amputation, diabetes, multiple sclerosis, use of modified footwear or custom orthotics, purely biomechanical studies, and outcomes of balance or falls only. Single-case studies, qualitative narrative descriptions, and expert opinions were also excluded.

Results:
The initial search resulted in a total of 417 citations. Eleven articles met inclusion criteria. Two randomized controlled trials and 3 quasiexperimental studies reported lateral wedge insoles may have at least some pain-relieving effects and improved functional mobility in older adults at 4 weeks to 2 years' follow-up, particularly when used with subtalar and ankle strapping. Three randomized controlled trials with large sample sizes reported that lateral wedges provided no knee pain relief compared with flat insoles. Hardness of shoe soles did not significantly affect joint comfort in the foot in a quasiexperimental study. A quasiexperimental designed study investigating shock-absorbing insoles showed reduction in knee joint pain with 1 month of wear. Finally, a cross-sectional prognostic study indicated poor footwear at early ages exhibits an association with hindfoot pain later in life.

Discussion and Conclusion:
Because of the limited number of randomized control trials, it is not possible to make a definitive conclusion about the long-term effects of footwear on lower extremity joint pain caused by OA. There is mounting evidence that shock-absorbing insoles, subtalar strapping, and avoidance of high heels and sandals early in life may prevent lower extremity joint pain in older adults, but no conclusive evidence exists to show that lateral wedge insoles will provide long-term relief from knee joint pain and improved mobility in older adults with OA. More high-quality randomized control trials are needed to study the effectiveness of footwear and shoe inserts on joint pain and function in older adults with OA.
Validity and Relative Ability of 4 Balance Tests to Identify Fall Status of Older Adults With Type 2 Diabetes
Authors: Marques Alda , Silva Alexandre , Oliveira Ana , Cruz Joana , Machado Ana , Jácome Cristina 
Published: November 2016

Background and Purpose:
The Berg Balance Scale (BBS), the Balance Evaluation Systems Test (BESTest), the Mini-BESTest, and the Brief-BESTest are useful tests to assess balance; however, their clinimetric properties have not been studied well in older adults with type 2 diabetes (T2D). This study compared the validity and relative ability of the BBS, BESTest, Mini-BESTest, and Brief-BESTest to identify fall status in older adults with T2D.

Methods:
This study involved a cross-sectional design. Sixty-six older adults with T2D (75 ± 7.6 years) were included and asked to report the number of falls during the previous 12 months and to complete the Activities-specific Balance Confidence scale. The BBS and the BESTest were administered, and the Mini-BESTest and Brief-BESTest scores were computed based on the BESTest performance. Receiver operating characteristics were used to assess the ability of each balance test to differentiate between participants with and without a history of falls.

Results:
The 4 balance tests were able to identify fall status (areas under the curve = 0.74-0.76), with similar sensitivity (60%-67%) and specificity (71%-76%).

Conclusions:
The 4 balance tests were able to differentiate between older adults with T2D with and without a history of falls. As the BBS and the BESTest require longer application time, the Brief-BESTest may be an appropriate choice to use in clinical practice to detect fall risk.
Developmental Wiring of Specific Neurons Is Regulated by RET-1/Nogo-A in Caenorhabditis elegans
Authors: Torpe Nanna , Nørgaard Steffen , Høye Anette M , Pocock Roger 
Published: November 2016

Abstract
Nogo-A is a membrane-bound protein that functions to inhibit neuronal migration, adhesion, and neurite outgrowth during development. In the mature nervous system, Nogo-A stabilizes neuronal wiring to inhibit neuronal plasticity and regeneration after injury. Here, we show that RET-1, the sole Nogo-A homolog in Caenorhabditis elegans, is required to control developmental wiring of a specific subset of neurons. In ret-1 deletion mutant animals, specific ventral nerve cord axons are misguided where they fail to respect the ventral midline boundary. We found that ret-1 is expressed in multiple neurons during development, and, through mosaic analysis, showed that ret-1 controls axon guidance in a cell-autonomous manner. Finally, as in mammals, ret-1 regulates ephrin expression, and dysregulation of the ephrin ligand VAB-2 is partially responsible for the ret-1 mutant axonal defects. Together, our data present a previously unidentified function for RET-1 in the nervous system of C. elegans.
The life of the line: A sketch by Paulo Mendes da Rocha for the Museu de Arte Contemporânea da Universidade de São Paulo
Authors: Pisani Daniele 
Published: November 2016

Resumen En oposición a la tendencia de considerar el dibujo arquitectónico como una simple fuente de información sobre el proyecto, o limitarse a contemplar su eventual belleza, este ensayo pretende analizar un boceto en su especificidad. Para hacer este tipo de experimento, el texto utiliza uno de los muchos bocetos realizados por Paulo Mendes da Rocha durante la preparación del proyecto para el Museo de Arte Contemporáneo de la Universidad de Sao Paulo (1974-1975). El objetivo no es aislar artificialmente un dibujo entre los muchos otros que le dan una autonomía que no le es propia, sino adoptar un nuevo punto de vista, a través del análisis de un diseño dentro del universo de diseño específico del arquitecto brasileño.Abstract Against the tendency to consider the drawing in architecture as a simple source of information about the project, or simply to contemplate its potential beauty, this essay aims to analyse one it in its specificity. To carry out this experiment, the text uses one of the many sketches made by Paulo Mendes da Rocha during the preparation of the project for the Museum of Contemporary Art from University of São Paulo (1974-1975). The aim is not to artificially isolate one drawing among the many, giving it an autonomy that it does not possess, but to adopt a new point of view on the universe of the Brazilian architect.
Gentrificación estratégica
Authors: Fiori Arantes Otilia Beatriz , Montes (Traductora) Ana Paula 
Published: November 2016

Resumen Para la Revista de Arquitectura de la Universidad de Costa Rica es un honor presentar una traducción al español de este artículo que fue originalmente publicado en portugués en Berlim e Barcelona. Duas imagens estratégicas. São Paulo: Annablume, 1a edição, 2012, pp. 13-26 bajo el título “Gentrificação Estratégica”.Este ensayo aborda la discusión en torno al énfasis superlativo que asume la industria cultural en la incorporación de la ciudad a la transnacionalización productiva y financiera. Se argumenta que, desde el discurso de la cultura, se justifica la utilización de una jerga de civilidad, (doctrina punitiva), dentro del conjunto de prácticas de revalorización urbana y plani cación estratégica, (gentrificación - privatización) bajo la promesa de crecimiento, empleo y negocios y el objetivo de cristalizar aquella imagen mítica del rentable bienestar de la ultra modernidad. Para esto, los ejemplos arquetípicos (Barcelona, París, Lisboa, Bilbao, Boston, Manhattan y Baltimore) sirven para ilustrar la noción de ciudad comprendida como una máquina de crecimiento.AbstractFor the Journal of Architecture of the University of Costa Rica is an honor to present a Spanish translation of the article “Gentrificação Estratégica”, originally published in portuguese in Berlim e Barcelona. Duas imagens estratégicas. São Paulo: Annablume, 1a edição, 2012, pp.13-26.This essay discusses the superlative emphasis assumed by the cultural industry in incorporating the city into productive and financial transnationalization. It is argued that through the discourse on culture, the vocabulary of civility is justified and incorporated into the set of practices of urban regeneration and strategic planning (gentrification – privatization) under the promise of growing employment and businesses which crystallize the mythical image of profitable ultra modernity. In doing so, archetypal examples (Barcelona, Paris, Lisbon, Bilbao, Boston, Manhattan, Baltimore) serve to illustrate the notion of city understood as a growth machine.