bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recent and Long-Term Soccer Heading Exposure Is Differentially Associated With Neuropsychological Function in Amateur Players
Authors: Levitch Cara F. , Zimmerman Molly E. , Lubin Naomi , Kim Namhee , Lipton Richard B. , Stewart Walter F. , Kim Mimi , Lipton Michael L. 
Published: August 2017

AbstractObjectives:The present study examined the relative contribution of recent or long-term heading to neuropsychological function in amateur adult soccer players.Participants and Methods:Soccer players completed a baseline questionnaire (HeadCount-12m) to ascertain heading during the prior 12 months (long-term heading, LTH) and an online questionnaire (HeadCount-2w) every 3 months to ascertain heading during the prior 2 weeks (recent heading, RH). Cogstate, a battery of six neuropsychological tests, was administered to assess neuropsychological function. Generalized estimating equations were used to test if LTH or RH was associated with neuropsychological function while accounting for the role of recognized concussion.Results:A total of 311 soccer players completed 630 HeadCount-2w. Participants had an average age of 26 years. Participants headed the ball a median of 611 times/year (mean=1,384.03) and 9.50 times/2 weeks (mean=34.17). High levels of RH were significantly associated with reduced performance on a task of psychomotor speed (p=.02), while high levels of LTH were significantly associated with poorer performance on tasks of verbal learning (p=.03) and verbal memory (p=.04). Significantly better attention (p=.02) was detectable at moderately high levels of RH, but not at the highest level of RH. One hundred and seven (34.4%) participants reported a lifetime history of concussion, but this was not related to neuropsychological function and did not modify the association of RH or LTH with neuropsychological function.Conclusion:High levels of both RH and LTH were associated with poorer neuropsychological function, but on different domains. The clinical manifestations following repetitive exposure to heading could change with chronicity of exposure. (JINS, 2018,24, 147–155)
Model risk: illuminating the black box
Authors: Black R. , Tsanakas A. , Smith A. D. , Beck M. B. , Maclugash I. D. , Grewal J. , Witts L. , Morjaria N. , Green R. J. , Lim Z. 
Published: August 2017

AbstractThis paper presents latest thinking from the Institute and Faculty of Actuaries’ Model Risk Working Party and follows on from their Phase I work, Model Risk: Daring to Open the Black Box. This is a more practical paper and presents the contributors’ experiences of model risk gained from a wide range of financial and non-financial organisations with suggestions for good practice and proven methods to reduce model risk. After a recap of the Phase I work, examples of model risk communication are given covering communication: to the Board; to the regulator; and to external stakeholders. We present a practical framework for model risk management and quantification with examples of the key actors, processes and cultural challenge. Lessons learned are then presented from other industries that make extensive use of models and include the weather forecasting, software and aerospace industries. Finally, a series of case studies in practical model risk management and mitigation are presented from the contributors’ own experiences covering primarily financial services.
Labelling completeness and sodium content of packaged foods in India
Authors: Johnson Claire , Thout Sudhir Raj , Mohan Sailesh , Dunford Elizabeth , Farrand Clare , Wu Jason HY , He Feng J , Shivashankar Roopa , Webster Jacqui , Krishnan Anand , Garg Vandana , Maulik Pallab K , Prabhakaran Dorairaj , Neal Bruce 
Published: August 2017

AbstractObjectiveTo estimate the proportion of products meeting Indian government labelling regulations and to examine the Na levels in packaged foods sold in India.DesignNutritional composition data were collected from the labels of all packaged food products sold at Indian supermarkets in between 2012 and 2014. Proportions of products compliant with the Food Safety Standards Authority of India (FSSAI) regulations and labelled with Na content, and mean Na levels were calculated. Comparisons were made against 2010 data from Hyderabad and against the UK Department of Health (DoH) 2017 Na targets.SettingEleven large chain retail stores in Delhi and Hyderabad, India.SubjectsPackaged food products (n 5686) categorised into fourteen food groups, thirty-three food categories and ninety sub-categories.ResultsMore packaged food products (43 v. 34 %; P<0·001) were compliant with FSSAI regulations but less (32 v. 38 %; P<0·001) reported Na values compared with 2010. Food groups with the highest Na content were sauces and spreads (2217 mg/100 g) and convenience foods (1344 mg/100 g). Mean Na content in 2014 was higher in four food groups compared with 2010 and lower in none (P<0·05). Only 27 % of foods in sub-categories for which there are UK DoH benchmarks had Na levels below the targets.ConclusionsCompliance with nutrient labelling in India is improving but remains low. Many packaged food products have high levels of Na and there is no evidence that Indian packaged foods are becoming less salty.
Retrospective analysis of portal dosimetry pre-treatment quality assurance of prostate volumetric-modulated arc therapy (VMAT) plans
Authors: Maraghechi Borna , Davis Jack , Badu Shyam , Fleck Andre , Darko Johnson , Osei Ernest 
Published: August 2017

AbstractBackgroundElectronic portal imaging device (EPID) offers high-resolution digital image that can be compared with a predicted portal dose image. A very common method to quantitatively compare a measured and calculated dose distribution that is routinely used for quality assurance (QA) of volumetric-modulated arc therapy (VMAT) and intensity-modulated radiation therapy treatment plans is the evaluation of the gamma index. The purpose of this work was to evaluate the gamma passing rate (%GP), maximum gamma (γmax), average gamma (γave), maximum dose difference (DDmax) and the average dose difference (DDave) for various regions of interest using Varian’s implementation of three absolute dose gamma calculation techniques of improved, local, and combined improved and local.Methods and materialsWe analyzed 232 portal dose images from 100 prostate cancer patients’ VMAT plans obtained using the Varian EPID on TrueBeam Linacs.ResultsOur data show that the %GP, γmax and γave depend on the gamma calculation method and the acceptance criteria. Higher %GP values were obtained compared with both our current institutional action level and the American Association of Physicists in Medicine Task Group 119 recommendations.ConclusionsThe results of this study can be used to establish stricter action levels for pre-treatment QA of prostate VMAT plans. A stricter 3%/3 mm improved gamma criterion with a passing rate of 97% or the 2%/2 mm improved gamma criterion with a passing rate of 95% can be achieved without additional measurements or configurations.
Constraint handling rules with binders, patterns and generic quantification
Authors: SERRANO ALEJANDRO , HAGE JURRIAAN 
Published: August 2017

AbstractConstraint handling rules provide descriptions for constraint solvers. However, they fall short when those constraints specify some binding structure, like higher-rank types in a constraint-based type inference algorithm. In this paper, the term syntax of constraints is replaced by λ-tree syntax, in which binding is explicit, and a new ∇ generic quantifier is introduced, which is used to create new fresh constants.
Productive corecursion in logic programming
Authors: KOMENDANTSKAYA EKATERINA , LI YUE 
Published: August 2017

AbstractLogic Programming is a Turing complete language. As a consequence, designing algorithms that decide termination and non-termination of programs or decide inductive/coinductive soundness of formulae is a challenging task. For example, the existing state-of-the-art algorithms can only semi-decide coinductive soundness of queries in logic programming for regular formulae. Another, less famous, but equally fundamental and important undecidable property is productivity. If a derivation is infinite and coinductively sound, we may ask whether the computed answer it determines actually computes an infinite formula. If it does, the infinite computation is productive. This intuition was first expressed under the name of computations at infinity in the 80s. In modern days of the Internet and stream processing, its importance lies in connection to infinite data structure processing. Recently, an algorithm was presented that semi-decides a weaker property – of productivity of logic programs. A logic program is productive if it can give rise to productive derivations. In this paper, we strengthen these recent results. We propose a method that semi-decides productivity of individual derivations for regular formulae. Thus, we at last give an algorithmic counterpart to the notion of productivity of derivations in logic programming. This is the first algorithmic solution to the problem since it was raised more than 30 years ago. We also present an implementation of this algorithm.
Observation of ultrahigh mobility surface states in a topological crystalline insulator by infrared spectroscopy
Authors: Wang Ying , Luo Guoyu , Liu Junwei , Sankar R. , Wang Nan-Lin , Chou Fangcheng , Fu Liang , Li Zhiqiang 
Published: August 2017

AbstractTopological crystalline insulators possess metallic surface states protected by crystalline symmetry, which are a versatile platform for exploring topological phenomena and potential applications. However, progress in this field has been hindered by the challenge to probe optical and transport properties of the surface states owing to the presence of bulk carriers. Here, we report infrared reflectance measurements of a topological crystalline insulator, (001)-oriented Pb1−x
Sn
x
Se in zero and high magnetic fields. We demonstrate that the far-infrared conductivity is unexpectedly dominated by the surface states as a result of their unique band structure and the consequent small infrared penetration depth. Moreover, our experiments yield a surface mobility of 40,000 cm2 V−1 s−1, which is one of the highest reported values in topological materials, suggesting the viability of surface-dominated conduction in thin topological crystalline insulator crystals. These findings pave the way for exploring many exotic transport and optical phenomena and applications predicted for topological crystalline insulators.
A quantum spectrum analyzer enhanced by a nuclear spin memory
Authors: Rosskopf Tobias , Zopes Jonathan , Boss Jens M. , Degen Christian L. 
Published: August 2017

AbstractWe realize a two-qubit sensor designed for achieving high-spectral resolution in quantum sensing experiments. Our sensor consists of an active “sensing qubit” and a long-lived “memory qubit”, implemented by the electronic and the nitrogen-15 nuclear spins of a nitrogen-vacancy center in diamond, respectively. Using state storage times of up to 45 ms, we demonstrate spectroscopy of external ac signals with a line width of 19 Hz (∼2.9 ppm) and of carbon-13 nuclear magnetic resonance signals with a line width of 190 Hz (∼74 ppm). This represents an up to 100-fold improvement in spectral resolution compared to measurements without nuclear memory.
Manipulating the adhesion of electroless nickel-phosphorus film on silicon wafers by silane compound modification and rapid thermal annealing
Authors: Hsu Chin-Wei , Wang Wei-Yen , Wang Kuan-Ting , Chen Hou-An , Wei Tzu-Chien 
Published: August 2017

AbstractIn this study, the effect of 3-2-(2-aminoethylamino) ethylamino propyl trimethoxysilane (ETAS) modification and post rapid thermal annealing (RTA) treatment on the adhesion of electroless plated nickel-phosphorus (ELP Ni-P) film on polyvinyl alcohol-capped palladium nanoclusters (PVA-Pd) catalyzed silicon wafers is systematically investigated. Characterized by pull-off adhesion, atomic force microscopy, X-ray spectroscopy and water contact angle, a time-dependent, three-staged ETAS grafting mechanism including islandish grafting, a self-assembly monolayer (SAM) and multi-layer grafting is proposed and this mechanism is well correlated to the pull-off adhesion of ELP Ni-P film. In the absence of RTA, the highest ELP Ni-P film adhesion occurs when ETAS modification approaches SAM, where insufficient or multi-layer ETAS grafting fails to provide satisfactory results. On the other hand, if RTA is applied, the best ELP Ni-P film adhesion happens when ETAS modification is islandish owing to the formation of nickel silicide, where SAM or multi-layer ETAS modification cannot provide satisfactory adhesion because the interaction between ETAS and PVA-Pd has been sabotaged during RTA. Evidenced by microstructural images, we also confirmed that ETAS can act as an efficient barrier layer for nickel diffusion to bulk silicon.
Determining the geographical origin of common buckwheat from China by multivariate analysis based on mineral elements, amino acids and vitamins
Authors: Zhang Qiang , Xu Jian-Guo 
Published: August 2017

AbstractThis study aimed to establish a method for distinguishing the geographical origin of common buckwheat from Inner Mongolia, Shanxi and Shaanxi Provinces in China. Three chemical families including mineral elements, vitamins and amino acids of 48 samples from different geographical origins were analyzed by principal component analysis (PCA), cluster analysis (CA) and linear discriminate analysis (LDA) for this purpose. LDA clearly discriminated the geographical origin of common buckwheat samples grown in three regions, and gave a high correct classification rate of 95.8% and satisfactory cross-validation rate of 91.7%. Some variables (Mn, VPP, Se, Gly, Cu, Asp, Fe, and Ala) significantly contributed to the ability to discriminate the geographical origin of the common buckwheat. These results demonstrated that the proposed method is a powerful tool for controlling the geographical origin of common buckwheat by governmental administration and protecting consumers from improper domestic labeling. However, the discriminant method still needs to be further validated using more reliable data.
Formation of Thermally Stable Bulk Heterojunction by Reducing the Polymer and Fullerene Intermixing
Authors: Jang Yoonhee , Ju Cho Yun , Kim Minjung , Seok Jeesoo , Ahn Hyungju , Kim Kyungkon 
Published: August 2017

AbstractA morphologically stable bulk heterojunction (BHJ) with a large heterojunction area is prepared by reducing the portion of the small band gap polymer (PTB7) and fullerene intermixture through a sequential deposition (SqD) of the nanostructured PTB7 and the fullerene layer. The nanostructured PTB7 layer is prepared using a ternary solvent composed of chlorobenzene, 1,8-diiodooctane (DIO) and 1-chloronaphthalene (1-CN). Adding DIO and 1-CN enhances the ordering of PTB7 chains and results in a nanostructured polymer surface. The grazing incidence X-ray diffraction results reveal that the SqD of the nanostructured PTB7 and fullerene layers forms the BHJ with little intermixing between the polymer and the fullerene domains compared to the BHJ formed by the deposition of the blended PTB7 and fullerene solution (BSD). The OPV utilizing the SqD processed BHJ (SqD-OPV) exhibits a power conversion efficiency (PCE) of 7.43%, which is similar to that when the BSD processed BHJ (BSD-OPV) is utilized. Furthermore, the SqD-OPV exhibits an excellent thermal stability. The SqD-OPV maintains its initial PCE even after thermal annealing at 140 °C for 10 days, whereas the BSD-OPV maintains 78% of its initial efficiency under the same condition.
Poisson Plus Quantification for Digital PCR Systems
Authors: Majumdar Nivedita , Banerjee Swapnonil , Pallas Michael , Wessel Thomas , Hegerich Patricia 
Published: August 2017

AbstractDigital PCR, a state-of-the-art nucleic acid quantification technique, works by spreading the target material across a large number of partitions. The average number of molecules per partition is estimated using Poisson statistics, and then converted into concentration by dividing by partition volume. In this standard approach, identical partition sizing is assumed. Violations of this assumption result in underestimation of target quantity, when using Poisson modeling, especially at higher concentrations. The Poisson-Plus Model accommodates for this underestimation, if statistics of the volume variation are well characterized. The volume variation was measured on the chip array based QuantStudio 3D Digital PCR System using the ROX fluorescence level as a proxy for effective load volume per through-hole. Monte Carlo simulations demonstrate the efficacy of the proposed correction. Empirical measurement of model parameters characterizing the effective load volume on QuantStudio 3D Digital PCR chips is presented. The model was used to analyze digital PCR experiments and showed improved accuracy in quantification. At the higher concentrations, the modeling must take effective fill volume variation into account to produce accurate estimates. The extent of the difference from the standard to the new modeling is positively correlated to the extent of fill volume variation in the effective load of your reactions.
Modelling of growth kinetics of Vibrio cholerae in presence of gold nanoparticles: effect of size and morphology
Authors: Chatterjee Tanaya , Chatterjee Barun K. , Chakrabarti Pinak 
Published: August 2017

AbstractEmergence of multiple drug resistant strains of pathogenic bacteria calls for new initiatives to combat infectious diseases. Gold nanoparticles (AuNPs), because of their non-toxic nature and size/shape dependent optical properties, offer interesting possibility. Here we report the antibacterial efficacy of AuNPs of different size and shape (AuNS10, AuNS100 and AuNR10; the number indicating the diameter in nm; S stands for sphere and R for rod) against the classical (O395) and El Tor (N16961) biotypes of Vibrio cholerae, the etiological agent responsible for cholera. Growth kinetics was monitored by measuring optical density at different time intervals and fitted by non-linear regression of modified Buchanan model. Sigmoidal growth curve for VcO395 indicated the existence of single phenotype population and was affected by AuNR10 only, implying the importance of morphology of AuNP. Growth of VcN16961 was affected by all three AuNPs indicating the vulnerability of El Tor biotype. Interestingly, VcN16961 exhibited the occurrence of two phenotypic subpopulations – one with shorter (vulnerable Type 1) and the other with extended (tolerant Type 2) lag phase. Various assays were conducted to probe the impact of AuNPs on bacterial cells. Apart from AuNR10, antimicrobial efficacy of AuNS10 was better compared to AuNS100.
Predictive Value of Serum Gamma-glutamyltranspeptidase for Future Cardiometabolic Dysregulation in Adolescents- a 10-year longitudinal study
Authors: Lin Chien-Ming , Hsieh Chang-Hsun , Lee Chien-Hsing , Pei Dee , Lin Jiunn-Diann , Wu Chung-Ze , Liang Yao-Jen , Hung Yi-Jen , Chen Yen-Lin 
Published: August 2017

AbstractSerum gamma-glutamyltransferase (γ-GT) is implicated in the pathogenesis of atherosclerosis and metabolic syndrome (MetS) in adults. The relationships between γ-GT and cardiometabolic dysregulation remains unclear in adolescents. We enrolled 7,072 Taiwanese adolescents and followed them for a median of 6.8 years. The optimal cut-off values (CoVs) of baseline γ-GT to predict future MetS, hypertension (HTN), and type 2 diabetes (T2DM) were determined by receiving operating characteristic (ROC) curve. Using these CoVs, the participants were divided into normal- and high-level groups. Cox proportional hazard analysis was used to calculate hazard ratios (HRs) for the subjects with a high level of γ-GT for the risk of future cardiometabolic dysregulation. Serum γ-GT was significantly higher in the subjects with MetS than in those without MetS at baseline (p < 0.001). The optimal CoVs of γ-GT were 12 U/L for boys and 11 U/L for girls. In multivariate Cox regression analysis, a higher serum γ-GT level increased the risk of future MetS (HRs 1.98 and 2.85 for boys and girls, respectively, both p < 0.001), but not new onset HTN and T2DM. In conclusion, serum γ-GT levels not only demonstrated an excellent correlation with the presence of MetS and also in predicting future MetS in adolescents.
Drug-Delivery System Based on Salmon DNA Nano- and Micro-Scale Structures
Authors: Lee Yunwoo , Dugansani Sreekantha Reddy , Jeon So Hee , Hwang Soon Hyoung , Kim Jae-Hyun , Park Sung Ha , Jeong Jun-Ho 
Published: August 2017

AbstractMicroneedles, fabricated by nano-moulding technology show great promise in the field of drug delivery by enabling the painless self-administration of drugs in a patient-friendly manner. In this study, double-stranded salmon DNA (SDNA) was used as both a drug-delivery vehicle and structural material with a microneedle system. SDNA is non-toxic and demonstrates good mechanical robustness, mouldability, biocompatibility, bio-absorbability, and binding affinity with drug molecules for bio-functional applications. Benign fabrication conditions to protect temperature-sensitive biomolecules are used to produce SDNA structures of various sizes with a high aspect ratio (4: 1). Unlike existing dissolving microneedle structure materials, the special binding characteristics of doxorubicin hydrochloride, anti-cancer drug molecules, and SDNA demonstrate the stability of drug-molecule encapsulation via UV-absorption and photoluminescence analyses. Based on COMSOL simulation andin vitroanalysis of the stratum corneum of porcine skin, the mechanical functionality of SDNA microneedles was evaluatedin vitroby penetrating the stratum corneum of porcine skin. The SDNA microneedle dissolved and drug permeation was assessed using rhodamine, a drug surrogate. Owing to its many beneficial characteristics, we anticipate that the SDNA microneedle platform will serve as an effective alternative for drug delivery.
Hospital-acquired Clostridium difficile infection in Mainland China: A seven-year (2009–2016) retrospective study in a large university hospital
Authors: Xu Qiaomai , Chen Yunbo , Gu Silan , Lv Tao , Zheng Beiwen , Shen Ping , Quan Jiazheng , Fang Yunhui , Li Lanjuan 
Published: August 2017

AbstractClostridium difficileinfection (CDI) is associated with risk for severe disease and high mortality. Little is known about the extent of hospital-acquired CDI in Mainland China. In this study, we aimed to investigate the annual CDI incidence, bacterial genotypes, risk factors for severe CDI and survival over a 7-year period. A total of 307 hospital-acquired CDI patients were enrolled, and 70.7% of these cases were male. CDI incidence was 3.4 per 10,000 admissions. Thirty-three different sequence types (STs) were identified, among which ST-54 (18.2%), ST-35 (16.6%) and ST-37 (12.1%) were the most prevalent. During the follow-up period, 66 (21.5%) patients developed severe CDI and 32 (10.4%) patients died in 30 days. Multivariate analysis revealed that bloodstream infection, pulmonary infection and C-reactive protein were significantly associated with severe CDI. After adjustment for potential confounders, old age, bloodstream infection, fever, mechanical ventilation, connective tissue disease, macrolide use and hypoalbuminaemia were independently associated with 30-day mortality in patients with CDI. The CDI prevalence has been low and stable in our center, and STs ofClostridium difficilewere different from dominant STs in Western countries. Our data emphasize the need of continued education and surveillance of CDI to reduce the CDI burden in China.