bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microfluidics: A high-throughput system for the assessment of the endotheliopathy of trauma and the effect of timing of plasma administration on ameliorating shock-associated endothelial dysfunction
Authors: Diebel Lawrence N. , Martin Jonathan V. , Liberati David M. 
Published: December 2017

BACKGROUND
Early resuscitation after trauma-hemorrhagic shock with plasma rather than crystalloid may ameliorate systemic endothelial cell (EC) injury and dysfunction (endotheliopathy of trauma). We postulated that endothelial-lined microfluidic networks would be a useful platform to study the EC activation/injury under flow conditions to mimic trauma-hemorrhagic shock. We then used the microfluidic system to further characterize the protective effects and optimal timing of plasma infusion on the development of “endotheliopathy of trauma” in our model.

METHODS
Human umbilical vein ECs were added to microfluidic flow channels, and after overnight perfusion, the cells were subsequently treated with epinephrine and exposed to hypoxia reoxygenation. Media alone or 5% human plasma was perfused either immediately following treatment (early plasma) or after a 3-hour delay (late plasma). Glycocalyx injury was indexed by fluorescent microscopy and shedding of syndecan 1 and hyaluronic acid. Endothelial markers of activation/injury were also measured and included soluble thrombomodulin, tissue plasminogen activator, plasminogen activator inhibitor 1, and angiopoietins 1 and 2. Sheddase activity was indexed by ADAM metallopeptidase domain 17.

RESULTS
Endothelial cell and glycocalyx barrier function studies using microfluidic devices are a more realistic model of the glycocalyx endothelial vascular barrier than studies performed on ECs using static (no flow) conditions. Conditions that mimic the internal milieu following hemorrhagic shock result in glycocalyx degradation and an inflammatory prothrombotic response by the endothelium. “Early” use of plasma in the microfluidic channel perfusate mitigated against these effects. Later perfusion with plasma had no protective effect.

CONCLUSIONS
A temporal effect to plasma administration was noted in our biomimetic model of the endothelial vascular barrier following shock. This suggests a protective role to “early” plasma administration in the severely injured patient.
A Profile of Neuro-Ophthalmic Practice Around the World
Authors: Frohman Larry P. 
Published: December 2017

Background:
To compare contrast neuro-ophthalmic practice in various countries, an 18-question survey was sent to the international North American Neuro-Ophthalmology Society (NANOS) members in the spring of 2016.

Methods:
At least 1 NANOS member was contacted for each non-US nation in the NANOS membership roster. If there were multiple NANOS members from 1 country, multiple were contacted. If responses were received from more than 1 person from a single country, the first response received was used as the source data. The survey (in English) was emailed to 47 NANOS members from 31 countries. Twenty responses were received representing members from 15 nations.

Results:
In all 15 nations, at least half of the neuro-ophthalmologists were trained as ophthalmologists. In 60% of nations, at least half of the neuro-ophthalmologists were trained internally, whereas in 33% of countries, at least half were trained in the United States. The number of physicians who practiced a significant amount of neuro-ophthalmology ranged from low (0.08/million, India) to high (3.10/million, Israel). Countries having the highest percentage of neuro-ophthalmologists exclusively practicing neuro-ophthalmology also were those with better patient access to neuro-ophthalmic care. Requirement of approval to see a neuro-ophthalmologist or for imaging studies requested by neuro-ophthalmologists was not typical. In most nations, academic neuro-ophthalmologists were paid a straight salary. In no nation were neuro-ophthalmologists paid more than another ophthalmic subspecialty.

Conclusions:
Individual national health care system designs and compensation models have had a profound influence on the rewards and challenges that face neuro-ophthalmologists. There seems to have been a connection between recognition of the discipline, financial rewards of neuro-ophthalmic practice, conditions that permit full-time neuro-ophthalmic practice, and patient access to care. A higher percentage of gross national product for health care did not seem to insure an adequate supply of neuro-ophthalmologists.
Transgenerational cues about local mate competition affect offspring sex ratios in the spider mite Tetranychus urticae
Authors: Duncan Alison B. , Marinosci Cassandra , Devaux Céline , Lefèvre Sophie , Magalhães Sara , Griffin Joanne , Valente Adeline , Ronce Ophélie , Olivieri Isabelle 
Published: December 2017

ABSTRACTThis preprint has been reviewed and recommended by Peer Community In Evolutionary Biology (https://doi.org/10.24072/pci.evolbiol.100051). In structured populations, competition for mates between closely related males, termed Local Mate Competition (LMC), is expected to select for female-biased offspring sex ratios. However, the cues underlying sex allocation decisions remain poorly studied. Here, we test for several cues in the spider mite Tetranychus urticae, a species that was previously found to adjust the sex ratio of its offspring in response to the number of females within the local population, i.e. a patch. We here investigate whether the offspring sex ratio of T. urticae females changes in response to 1) the current number of females in the same patch, 2) the number of females in the patches of their mothers and 3) their relatedness to their mate. Single females on patches produced similar sex ratios to those of groups of 15 females; their mothers had been in identical conditions of panmixia. The offspring sex ratios of females mated with their brother did not differ from those of females mated with an unrelated male. Females however produced a more female-biased offspring sex ratio if their mothers were alone on a patch compared to 15 other females. Thus, maternal environment is used as a cue for the sex allocation of daughters. We discuss the conditions under which the maternal environment may be a reliable predictor of LMC experienced by grand-sons.
Species delimitation in the presence of strong incomplete lineage sorting and hybridization: lessons fromOphioderma(Ophiuroidea: Echinodermata)
Authors: Weber Alexandra Anh-Thu , Stöhr Sabine , Chenuil Anne 
Published: December 2017

AbstractAccurate species delimitation is essential to properly assess biodiversity, but also for management and conservation purposes. Yet, it is not always trivial to accurately define species boundaries in closely related species due to incomplete lineage sorting. Additional difficulties may be caused by hybridization, now evidenced as a frequent phenomenon. The brittle star cryptic species complexOphioderma longicaudaencompasses six mitochondrial lineages, including broadcast spawners and internal brooders, yet the actual species boundaries are unknown. Here, we combined three methods to delimit species in theOphioderma longicaudacomplex and to infer its divergence history: i) unsupervised species discovery based on multilocus genotypes; ii) divergence time estimation using the multi-species coalescent; iii) divergence scenario testing (including gene flow) using Approximate Bayesian Computation (ABC) methods. 30 sequence markers (transcriptome-based, mitochondrial or non-coding) for 89O. longicaudaand outgroup individuals were used. First, multivariate analyses revealed six genetic clusters, which globally corresponded to the mitochondrial lineages, yet with many exceptions, suggesting ancient hybridization events and challenging traditional mitochondrial barcoding approaches. Second, multi-species coalescent-based analyses confirmed the occurrence of six species and provided divergence time estimates, but the sole use of this method failed to accurately delimit species, highlighting the power of multilocus genotype clustering to delimit recently diverged species. Finally, Approximate Bayesian Computation showed that the most likely scenario involves hybridization between brooders and broadcasters. Our study shows that despite strong incomplete lineage sorting and past hybridization, accurate species delimitation inOphiodermawas possible using a combination of complementary methods. We propose that these methods, especially multilocus genotype clustering, may be useful to resolve other complex speciation histories.HighlightsMultivariate analysis was used for species delimitationSixOphiodermaspecies were delimited using nuclear and mitochondrial dataOphiodermaspeciation history is complex and included hybridizationMitochondrial and nuclear histories differed, challenging barcoding approachesWe propose that using multilocus genotypes can resolve complex speciation histories
Pollinator Species Richness Trends: No Decelerating Declines in Dutch Bees and Bumblebees
Authors: Van Dooren Tom J. M. 
Published: December 2017

AbstractTemporal trends (1946–2013) in the species richness of wild bees from the Netherlands are analysed. We apply two methods to estimate richness change which both incorporate models for sampling effects and detection probability. The analysis is repeated for records with specimens deposited in collections, and a subset restricted to spatial grid cells that have been sampled repeatedly across three periods. When fitting non-linear species accumulation curves to species numbers, declines are inferred for bumblebees and at most limited declines for other bees. Capture-recapture analysis applied to species encounter histories infers a constant colonization rate per year and constant (bumblebees) or decreasing (other) local species survival. However, simulations suggest that the method estimates time trends in survival with a negative bias. Species richness trends predicted by the second approach are a 10% reduction in non-Bombus species richness and 29% fewer Bombus species since 1946, comparable to the predictions of the first approach. Neither analysis provides reliable evidence that decelerating declines in species richness occur in these taxa. Therefore we should not infer decelerating declines in pollinator species richness in N-W Europe as previously claimed.
sFlt-1 (sVEGFR1) induces placental endoplasmic reticulum stress in trophoblast cell: implications for the complications in preeclampsia- an in vitro study
Authors: Mochan Sankat , Dhingra Manoj Kumar , Varghese Betsy , Gupta Sunil Kumar , saxena Shobhit , Arora Pallavi , Rani Neerja , Sharma Arundhati , Luthra Kalpana , Dwivedi Sadanand , Bhatla Neerja , Kumar Rani , Dhingra Renu 
Published: December 2017

AbstractBackgroundThe concentration of sFlt-1, a major anti-angiogenic protein in maternal circulation has been seen to be raised in preeclamptic pregnancies. Endoplasmic reticulum (ER) stress represents one of the three (immunological, oxidative and ER stress) major stresses which placenta undergoes during pregnancies. The present study is designed to investigate the role of sFlt-1 in induction of ER stress in trophoblast cells.Materials and MethodsMaternal serum levels of anti-angiogenic protein sFlt-1 and central regulator of unfolded protein response GRP78 was measured using sandwich ELISA. The expression of various ER stress markers (GRP78, eIF2α, XBP1, ATF6 and apoptotic protein CHOP) were analyzed depending on various treatments given to the trophoblast cells using Immunofluorescence, western blot and q-RT PCR.ResultsIncreased expression of ER stress markers (GRP78, eIF2α, XBP1 ATF6 and apoptotic protein CHOP) was detected in the placental trophoblast cells treated with raised concentration of sFlt-1.ConclusionSignificant upregulated expression of ER stress markers in trophoblast cells exposed with increased concentration of sFlt-1 suggested that it may be one of the anti-angiogenic factors present in maternal sera which not only contributes to oxidative stress but also may cause endoplasmic reticulum stress.
Toward open manufacturing
Authors: Li Zhi , Wang W.M. , Liu Guo , Liu Layne , He Jiadong , Huang G.Q. 
Published: December 2017

Purpose
The purpose of this paper is to propose a cross-enterprises framework to achieve a higher level of sharing of knowledge and services in manufacturing ecosystems.

Design/methodology/approach
The authors describe the development of the emerging open manufacturing and discuss the model of knowledge creation processes of manufacturers. The authors present a decentralized framework based on blockchain and edge computing technologies, which consists of a customer layer, an enterprise layer, an application layer, an intelligence layer, a data layer, and an infrastructure layer. And a case study is provided to illustrate the effectiveness of the framework.

Findings
The authors discuss that the manufacturing ecosystem is changing from integrated and centralized systems to shared and distributed systems. The proposed framework incorporates the recent development in blockchain and edge computing that can meet the secure and distributed requirements for the sharing of knowledge and services in manufacturing ecosystems.

Practical implications
The proposed framework provides a more secure and controlled way to share knowledge and services, thereby supports the company to develop scalable and flexible business at a lower cost, and ultimately improves the overall quality, efficiency, and effectiveness of manufacturing services.

Originality/value
The proposed framework incorporates the recent development in edge computing technologies to achieve a flexible and distributed network. With the blockchain technology, it provides standards and protocols for implementing the framework and ensures the security issues. Not only information can be shared, but the framework also supports in the exchange of knowledge and services so that the parties can contribute their parts.
IoT-based production logistics and supply chain system – Part 1
Authors: Tu Mengru , Lim Ming K. , Yang Ming-Fang 
Published: December 2017

Purpose
The lack of reference architecture for Internet of Things (IoT) modeling impedes the successful design and implementation of an IoT-based production logistics and supply chain system (PLSCS). The authors present this study in two parts to address this research issue. Part A proposes a unified IoT modeling framework to model the dynamics of distributed IoT processes, IoT devices, and IoT objects. The models of the framework can be leveraged to support the implementation architecture of an IoT-based PLSCS. The second part (Part B) of this study extends the discussion of implementation architecture proposed in Part A. Part B presents an IoT-based cyber-physical system framework and evaluates its performance. The paper aims to discuss this issue.

Design/methodology/approach
This paper adopts a design research approach, using ontology, process analysis, and Petri net modeling scheme to support IoT system modeling.

Findings
The proposed IoT system-modeling approach reduces the complexity of system development and increases system portability for IoT-based PLSCS. The IoT design models generated from the modeling can also be transformed to implementation logic.

Practical implications
The proposed IoT system-modeling framework and the implementation architecture can be used to develop an IoT-based PLSCS in the real industrial setting. The proposed modeling methods can be applied to many discrete manufacturing industries.

Originality/value
The IoT modeling framework developed in this study is the first in this field which decomposes IoT system design into ontology-, process-, and object-modeling layers. A novel implementation architecture also proposed to transform above IoT system design models into implementation logic. The developed prototype system can track product and different parts of the same product along a manufacturing supply chain.
Sustainable supply chain management practices and performance
Authors: Wang Jing , Dai Jun 
Published: December 2017

PurposeThe purpose of this paper is to contribute significantly to the empirical investigations related to the impact of sustainable supply chain management (SSCM) practices on performance in Chinese firms. The paper also aims to theorize and empirically assess a comprehensive SSCM practices and performance model. The model incorporates two aspects of SSCM practices: internal and external management, and analyses the impact on corporate sustainability performance from all dimensions.Design/methodology/approachThis paper develops a conceptual model to investigate the impact of SSCM practices on the firm performance. Based on the data of 172 Chinese firms, this paper analyzes the impact of SSCM practices on firm economic performance, environmental performance, and social performance for each dimension by using PLS structural equation methods.FindingsThe results show that firm’s internal SSCM practices have a positive impact on firm’s environmental performance and social performance. Moreover, environmental performance and social performance are positively related to economic performance.Originality/valueA comprehensive SSCM practices performance model is proposed and empirically assessed for Chinese firms. The results of this investigation support the hypotheses that SSCM practices are environmentally and socially necessary and are favorable for business. A series of approach and implications of SSCM practices is recommended.
Integrating a creativity, innovation, and design studio within an academic library
Authors: Zaugg Holt , Warr Melissa C. 
Published: December 2017

Purpose
The purpose of this paper is to describe the efforts to set up a creativity, innovation, and design (CID) studio within an academic library. This paper will describe the reasons for creating a CID studio, assessment of the pilot study, and next steps.

Design/methodology/approach
The assessment used surveys, interviews, focus groups and observations of students and faculty to determine how well the CID fits into the library.

Findings
Initial findings indicate that the CID studio is a good fit within the library space as learning activities in it support collaboration, discovery, and integration of library services. However, noise issues, equipment needs, and expansion of space are key future needs.

Research limitations/implications
As libraries move from simple repositories of information to places of learning and collaboration, a CID studio space provides an opportunity to integrate learning opportunities with library services.

Originality/value
Through the first iteration, the CID has a unique and purposeful place within an academic library. It provides the opportunity for greater integration of library services. However, future iterations need to address key issues of space, equipment, and noise.
The long-run performance of US firms pursuing IPOs in foreign markets
Authors: Killins Robert , Egly Peter V. 
Published: December 2017

Purpose
The purpose of this paper is to investigate the long-run performance of a unique set of US domiciled firms that have bypassed the US capital markets in pursuit of their initial public offering (IPO) overseas. Additionally, this paper then tests the popular underwriter prestige impact and the window of opportunity hypothesis on this unique subset of IPOs.

Design/methodology/approach
Using a sample of foreign and purely domestic IPOs made by US firms from 2000 to 2011, this study investigates the long-term performance, one-, two- and three-year by using two measures (buy-and-hold return and cumulative abnormal returns) to test the long-run returns of newly listed companies. Finally, the research incorporates both the traditional matching methodology (issue year and size) along with propensity score matching methodology.

Findings
FIPOs of US companies underperform DIPOs and their matched DIPOs; furthermore, FIPOs underperform the index of the two listing countries they use the most (UK and Canada). Although the choice of a reputable underwriter mitigates underperformance, the choice of listing in a foreign country only may be a result of possible high valuations accorded by foreign investors who buy US-listed companies on the domestic exchange possibly for reducing exchange rate risk and gaining US diversification without incurring additional costs. It is, thus, possible that US companies that undertake Foreign IPOs not only escape potentially higher Security and Exchange Commission regulations and disclosure but also benefit from higher valuations in the foreign markets.

Originality/value
To the best of the authors’ knowledge, this is the first study to investigate the long-term performance of US firms bypassing the US capital markets in pursuit of their initial equity offering elsewhere. Caglio et al. (2016) investigated why firms decide to pursue such equity raising activity but fail to investigate the firms’ actual performance after issuing equity. This research fills such a gap in the literature and is important for both academics and practitioners. Practitioners can use this information in assessing the quality of such investments in the long-run, and firms can use such information when determining the different options of issuing equity. Further, regulators should be aware of the implications that increased regulations have on capital raising activities in their domestic market.
Measuring accelerometer dynamic range from seismic data using Allan deviation
Authors: McDonald Matt , Stigborg Patrik 
Published: December 2017

ABSTRACTWe propose a new approach for calculating the dynamic range of an accelerometer based on an Allan deviation analysis of production seismic data. This test is intended as a field audit technique and does not require an unconditioned dataset from a low‐noise environment. We first show that Allan deviation can measure white noise levels using two commercial accelerometers. The analysis accurately captures the manufacturing noise density specifications and known relationships between white noise, preamplifier gain, and group forming. We then show that a production seismic dataset is suitable for an Allan deviation analysis because the results are not critically affected by a recording filter. Finally, we illustrate the proposed technique by calculating the dynamic range of an accelerometer channel in a seismic streamer using a production dataset.
Syntax and semantics of modal predicates in Indo‐European
Authors: Viti Carlotta 
Published: December 2017

AbstractThis paper discusses the syntactic variation of modal predicates between structures with a nominative primary argument and those with an oblique primary argument. In the literature, this variation is related to a change from deontic to epistemic meanings, whereby epistemicity seems to be more commonly expressed by highly grammaticalized impersonal constructions. After having shown the weakness of this relationship, I suggest a new explanation for the variation of modal predicates on the basis of diverse ancient Indo‐European languages, such as Vedic, Ancient Greek and Latin, as well as of some of their modern descendants, especially Hindi, Modern Greek, and standard and colloquial Italian. I argue that modal predicates with an oblique primary argument are favoured for functions of necessity, while modal predicates with a nominative primary argument preferably express functions of possibility. This reflects the different meanings of the lexical sources of these predicates, that is, capacity or power for predicates of possibility, and lack or obligation for predicates of necessity, which also imply different degrees of agentivity and control.