bluuebunny/crossref_metadata_2025_split huggingface dataset:
“Seize the Deal, or Return It Losing Your Free Gift”: The Effect of a Gift‐With‐Purchase Promotion on Product Return Intention
Authors: Lee Shinhyoung , Yi Youjae 
Published: February 2017

ABSTRACTThe current article sheds light on an important issue in marketing: how marketers can prevent consumers from returning previously purchased goods. This research examines the relationship between a gift‐with‐purchase promotion and consumer product returns, hypothesizing that consumers who purchase products that come with a free gift will be less likely to return the products. Evidence shows that a gift‐with‐purchase promotion reduces consumer product returns and that this relationship is mediated by perceived loss in returning a product. Then, the results indicate that the choice of free gifts reduces product return intention and that this relationship is serially mediated by perceived ownership and perceived loss. The findings further suggest that when consumers with high product involvement can select free gifts among alternatives, they tend to perceive more ownership and loss and thereby are less likely to return the promoted product. Overall, the current research proposes that consumers prefer to seize the deal rather than to return it when they get a gift‐with‐purchase, have a chance to select a free gift, and are highly involved with the product.
Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas
Authors: Bonnavion Rémy , Teinturier Romain , Gherardi Samuele , Leteurtre Emmanuelle , Yu Run , Cordier‐Bussat Martine , Du Rui , Pattou François , Vantyghem Marie‐Christine , Bertolino Philippe , Lu Jieli , Zhang Chang Xian 
Published: February 2017

AbstractFoxa2, known as one of the pioneer factors, plays a crucial role in islet development and endocrine functions. Its expression and biological functions are regulated by various factors, including, in particular, insulin and glucagon. However, its expression and biological role in adult pancreatic α‐cells remain elusive. In the current study, we showed that Foxa2 was overexpressed in islets from α‐cell‐specific Men1 mutant mice, at both the transcriptional level and the protein level. More importantly, immunostaining analyses showed its prominent nuclear accumulation, specifically in α‐cells, at a very early stage after Men1 disruption. Similar nuclear FOXA2 expression was also detected in a substantial proportion (12/19) of human multiple endocrine neoplasia type 1 (MEN1) glucagonomas. Interestingly, our data revealed an interaction between Foxa2 and menin encoded by the Men1 gene. Furthermore, using several approaches, we demonstrated the relevance of this interaction in the regulation of two tested Foxa2 target genes, including the autoregulation of the Foxa2 promoter by Foxa2 itself. The current study establishes menin, a novel protein partner of Foxa2, as a regulator of Foxa2, the biological functions of which extend beyond the pancreatic endocrine cells. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
IL‐1β induces thymic stromal lymphopoietin and an atopic dermatitis‐like phenotype in reconstructed healthy human epidermis
Authors: Bernard Marine , Carrasco Cédric , Laoubi Léo , Guiraud Béatrice , Rozières Aurore , Goujon Catherine , Duplan Hélène , Bessou‐Touya Sandrine , Nicolas Jean‐François , Vocanson Marc , Galliano Marie‐Florence 
Published: February 2017

AbstractAtopic dermatitis (AD) is a common skin inflammatory disease characterized by the production of thymic stromal lymphopoietin (TSLP) and marked TH2 polarization. Recent studies suggest that IL‐1β contributes to the development of AD skin inflammation. Here, we have investigated the impact of IL‐1β signalling on the epidermal homeostasis of both healthy subjects and AD patients [with functional filaggrin (FLG) alleles], with particular attention to TSLP production and keratinocyte differentiation. In healthy reconstructed human epidermis (RHE), IL‐1β promoted (i) robust secretion of TSLP in an NF‐κB‐dependent manner and (ii) a significant decrease in the expression of filaggrin and other proteins of the epidermal differentiation complex. These effects were prevented by treatment of RHE with the anti‐IL‐1β mAb canakinumab and by the IL‐1 receptor antagonist anakinra. Interestingly, RHE generated from AD donors behaved like that of healthy individuals and showed comparable responses to IL‐1β signals. Collectively, our results suggest that IL‐1β may be an early key mediator for the acquisition of an AD phenotype through induction of TSLP and alteration of the epidermal homeostasis. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Halloysite clay nanotubes as nano‐bazookas for drug delivery
Authors: Leporatti Stefano 
Published: February 2017

AbstractHalloysite nanotubes are cheap, abundant in their deposits, natural green clays with cylindrical structure having a chemical composition similar to that of kaolin. Because of their lumens, high aspect length–diameter ratio and low hydroxyl density on their surface they are readily suitable for a number of interesting applications. In this review we focus only on their use as ‘nano‐bazooka’ drug carriers, able to shoot their cargo against major diseases. Their structure, controlled release and loading are described. We emphasize especially their possible use as novel drug delivery systems with applications in nanomedicine. © 2017 Society of Chemical Industry
Characterisation of block copolymer self‐assemblies by thermal field‐flow fractionation
Authors: Greyling Guilaume , Pasch Harald 
Published: February 2017

AbstractThe ability of block copolymers to self‐assemble into various nanostructures (such as micelles) has attracted significant attention over the years as these block copolymers provide a versatile platform that can readily be modified for a wide range of applications. As such, the solution behaviour of block copolymers has been at the forefront of the modern nanotechnology revolution. However, these novel block copolymer‐based self‐assemblies lack suitable characterisation techniques to determine size, molar mass and compositional distributions simultaneously. This mini‐review gives a short background on the current techniques used to determine important micelle properties as well as their limitations for characterising complex samples. Current column‐based fractionation techniques used for determining property distributions are addressed. As a result of the limitations of column‐based fractionations, a multidetector thermal field‐flow fractionation (ThFFF) approach is put forward as a powerful alternative for determining not only size and molar mass distributions, but also other micelle properties as a function of temperature. More importantly, ThFFF is highlighted as the only current characterisation platform capable of addressing the analytical challenges associated with compositional distributions of polymer self‐assemblies. © 2017 Society of Chemical Industry
The Development of Prostate Adenocarcinoma in a Transgender Male to Female Patient: Could Estrogen Therapy Have Played a Role?
Authors: Sharif Asma , Malhotra Neha R. , Acosta Andres M. , Kajdacsy‐Balla Andre A. , Bosland Maarten , Guzman Grace , Prins Gail S. , Abern Michael R. 
Published: February 2017

BACKGROUNDProstate adenocarcinoma (PCa) is a rare diagnosis in the male to female transgender (MtFT) population with only a few case reports published in the current medical literature. Long standing beliefs of androgen suppression conferring a protective effect against prostate cancer development have been challenged by the literature citing adenocarcinoma development in the prostate of rodent models following combined estrogen and testosterone treatment.MATERIALS AND METHODSWe herein present a MtFT patient who presented with high grade PCa following 20 years of exogenous estrogen therapy.RESULTSImmunohistochemical (IHC) localization of estrogen receptor alpha (ER‐α) and progesterone receptor (PR) demonstrated positive staining in stromal cells; while, androgen receptor (AR) demonstrated positive staining in malignant glands and weak scattered staining in adjacent stroma.CONCLUSIONThis pattern of staining raises concern for a possible contributing role of exogenous estrogen therapy in tumorigenesis. As awareness of gender dysphoria and acceptance of gender reassignment surgery has seen a recent increase, the unique needs of this population must be recognized. Prostate 77:824–828, 2017. © 2017 Wiley Periodicals, Inc.
Migratory flight behaviour of the pollen beetle Meligethes aeneus
Authors: Mauchline Alice L , Cook Samantha M , Powell Wilf , Chapman Jason W , Osborne Juliet L 
Published: February 2017

AbstractBACKGROUNDThe field ecology of the pollen beetle Meligethes aeneus and its damaging effects on oilseed rape crops are well understood. However, the flight behaviour of M. aeneus, in particular the drivers for migratory movements across the landscape, is not well studied. We combined three established methodologies – suction traps, vertical‐looking radar and high‐altitude aerial netting – to demonstrate that M. aeneus flies at a range of altitudes at different points during its active season.RESULTSBy linking evidence of high‐altitude mass migration with immigration of pollen beetles into oilseed rape fields, we were able to ‘ground‐truth’ the results to characterise the seasonal movements of this pest across the landscape.CONCLUSIONWe demonstrate that this novel combination of methodologies can advance our understanding of the population movements of pollen beetles and could provide an opportunity to develop predictive models to estimate the severity and timing of pest outbreaks. © 2017 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
The Long-Term Cognitive and Socioeconomic Consequences of Birth Intervals: A Within-Family Sibling Comparison Using Swedish Register Data
Authors: Barclay Kieron J. , Kolk Martin 
Published: February 2017

AbstractWe examine the relationship between birth-to-birth intervals and a variety of mid- and long-term cognitive and socioeconomic outcomes, including high school GPA, cognitive ability, educational attainment, earnings, unemployment status, and receiving government welfare support. Using contemporary Swedish population register data and a within-family sibling comparison design, we find that neither the birth interval preceding the index person nor the birth interval following the index person are associated with any substantively meaningful changes in mid- or long-term outcomes. This is true even for individuals born before or after birth-to-birth intervals of less than 12 months. We conclude that in a contemporary high-income welfare state, there appears to be no relationship between unusually short or long birth intervals and adverse long-term outcomes.
New diagnostic biomarker in acute diarrhea due to bacterial infection in children
Authors: Al-Asy Hassan M. , Gamal Rasha M. , Albaset Ahmed M. Abd , Elsanosy Mohammed G. , Mabrouk Maali M. 
Published: February 2017

Background and objectives:
Diarrhea is a major cause of morbidity and mortality in children, and diarrhea may be due to infection that is bacterial or non-bacterial. Differentiation between diarrhea from a bacterial or non-bacterial infection is not a simple task, and no single method is present to differentiate between these causes of diarrhea.
To evaluate the diagnostic accuracy of soluble triggering receptor expressed on myeloid cells-1 (sTREM- 1) and procalcitonin (PCT) in the diagnosis of acute diarrhea due to bacterial infection.

Patients and methods:
Case control study of forty children with bacterial infection diarrhea diagnosed by stool culture and CRP, 40 children with acute non-bacterial infection diarrhea and 30 age- and sex- matched healthy controls. Stool cultures, serum CRP, PCT and serum sTREM-1 were measured in all children on admission.

Results:
Children with acute bacterial infection diarrhea had a significant increase in the serum sTREM-1 and PCT levels on admission compared to patients with nonbacterial infection diarrhea and controls (26.3667 ± 16.8184 ng/ml vs 7.2267 ± 6.4174 ng/ml vs 6.7367 ± 5.6479 ng/ml and 39.9933 ± 22.5260 ng/ ml vs 1.8533 ± 1.7123 vs 0.2840 ± 0.1208 ng/ml, respectively; P < 0.05). sTREM-1 demonstrated significantly higher sensitivity (93.7%) and specificity (94.3%) in the prediction of bacterial infection as a cause of acute diarrhea in children with an area under the receiver operator characteristic (ROC) curve (95% CI) of 0.94 (0.84-0.99) at a cutoff value of 12.4 ng/ml.

Conclusions:
Both serum PCT and sTREM-1 are valuable in the early diagnosis of acute bacterial infection- induced diarrhea in children, and there was markedly higher diagnostic discriminatory power for sTREM-1.
The Women's EMPOWER Survey: Women's Knowledge and Awareness of Treatment Options for Vulvar and Vaginal Atrophy Remains Inadequate
Authors: Krychman Michael , Graham Shelli , Bernick Brian , Mirkin Sebastian , Kingsberg Sheryl A. 
Published: February 2017

Abstract

Introduction
Postmenopausal women's knowledge about vulvar and vaginal atrophy (VVA) and available treatment options has historically been inadequate. Recent direct-to-consumer marketing and educational efforts would have been expected to increase awareness and treatment options.

Aim
To compare results of the Women's EMPOWER survey with other available VVA surveys to assess progress in women's understanding and approaches to treatment of VVA.

Methods
The Women's EMPOWER survey, an internet-based survey of US women with VVA symptoms, assessed women's awareness of VVA and their behaviors and attitudes associated with symptom treatment.

Main Outcome Measures
These survey results were compared with previously published results of the Revealing Vaginal Effects at Mid-Life (REVEAL), Women's Voices in Menopause (WVM), Vaginal Health: Insight, Views, & Attitudes (VIVA), Clarifying Vaginal Atrophy's Impact on Sex and Relationship (CLOSER), and Real Women's Views of Treatment Options for Menopausal Vaginal Changes (REVIVE) surveys.

Results
Results of the Women's EMPOWER survey were consistent with those of past VVA surveys and showed that postmenopausal women generally failed to recognize VVA and its chronic, progressive process and that they were reluctant to discuss vaginal or sexual symptoms with their health care professionals (HCPs). However, women indicated a strong desire for accurate medical information about VVA from their health care professionals and a willingness to learn if HCPs would initiate the conversation. Most women believed that vaginal symptoms are a normal part of aging and they just need to cope with the symptoms. In the United States, women were most concerned with safety-related issues, including increased risk of breast cancer, side effects, and systemic absorption.

Conclusion
The Women's EMPOWER survey demonstrates and reinforces that even with multimedia marketing and educational strategies in the years after other major VVA surveys, minimal progress has been made toward increasing women's awareness of, knowledge about, or understanding of VVA. Based on these data, a focus on initiating discussions and education with postmenopausal women so that they better comprehend VVA as a chronic progressive medical condition (not just aging), the symptoms associated with VVA, and the benefit-risk profile regarding treatment options is warranted.
Cumulative Adverse Childhood Experiences and Sexual Satisfaction in Sex Therapy Patients: What Role for Symptom Complexity?
Authors: Bigras Noémie , Godbout Natacha , Hébert Martine , Sabourin Stéphane 
Published: February 2017

Abstract

Introduction
Patients consulting for sexual difficulties frequently present additional personal or relational disorders and symptoms. This is especially the case when they have experienced cumulative adverse childhood experiences (CACEs), which are associated with symptom complexity. CACEs refer to the extent to which an individual has experienced an accumulation of different types of adverse childhood experiences including sexual, physical, and psychological abuse; neglect; exposure to inter-parental violence; and bullying. However, past studies have not examined how symptom complexity might relate to CACEs and sexual satisfaction and even less so in samples of adults consulting for sex therapy.

Aim
To document the presence of CACEs in a sample of individuals consulting for sexual difficulties and its potential association with sexual satisfaction through the development of symptom complexity operationalized through well-established clinically significant indicators of individual and relationship distress.

Methods
Men and women (n = 307) aged 18 years and older consulting for sexual difficulties completed a set of questionnaires during their initial assessment.

Main Outcome Measures
(i) Global Measure of Sexual Satisfaction Scale, (ii) Dyadic Adjustment Scale–4, (iii) Experiences in Close Relationships–12, (iv) Beck Depression Inventory–13, (v) Trauma Symptom Inventory–2, and (vi) Psychiatric Symptom Inventory–14.

Results
Results showed that 58.1% of women and 51.9% of men reported at least four forms of childhood adversity. The average number of CACEs was 4.10 (SD = 2.23) in women and 3.71 (SD = 2.08) in men. Structural equation modeling showed that CACEs contribute directly and indirectly to sexual satisfaction in adults consulting for sex therapy through clinically significant individual and relational symptom complexities.

Conclusion
The findings underscore the relevance of addressing clinically significant psychological and relational symptoms that can stem from CACEs when treating sexual difficulties in adults seeking sex therapy.
Structure de l’ensemble des équilibres d’une économie productive
Authors: Jouini Elyes 
Published: February 2017

In this paper we consider the equilibria set of a production economy in which the production sector may exhibit nonconvexities. We establish results on the structure (manifold, covering…) of this set which generalizes similar results on exchange economies.

Résumé

Dans ce papier nous généralisons au cas d’économies comportant plusieurs ensembles de production, éventuellement non convexes, les résultats concernant la structure de l’ensemble des équilibres, connus dans le cas des économies d’échange (
i.e
., sans production). Nous montrons en particulier que cet ensemble est une variété et qu’il constitue un revêtement de l’espace des allocations initiales. Nous établissons, en outre, que l’ensemble des économies possédant un nombre infini d’équilibres est de mesure nulle, ainsi qu’une version asymptotique de ce dernier résultat.
Desperately Seeking Daddy: A Critique of Pratten v British Columbia (Attorney General)
Authors: Chambers Lori , Hillsburg Heather 
Published: February 2017

Abstract
Current Canadian law, by silence rather than explicit choice, does not prevent anonymous sperm donation. Anonymous sperm donation, however, may soon disappear. In the recent Pratten decision, the Supreme Court of British Columbia determined that anonymity violates the constitutional rights of children born of Assisted Reproductive Technologies (ARTs). While finding that children should have access to genetic knowledge, the court failed to consider the impact of the elimination of anonymity on other parties to ARTs, both sperm donors and ART families. The case was appealed by the Attorney General of British Columbia and heard by the British Columbia Court of Appeal in February 2012 and was overturned. While agreeing with the decision of the Court of Appeal, this article argues that the court failed to provide a fulsome analysis of issues related to privacy, genetic knowledge, alternative family formation, and the false assertion that sperm donation makes a man a father.
Paramilitary Provision of Adequate Disaster Response and Advancement of Public Health: The Case of the Texas State Guard and Operation Lone Star
Authors: Johnson Ralph Jay 
Published: February 2017

AbstractObjectiveThis article reports on State Defense Forces (SDFs) as tools for providing coordinated, disciplined, trained, and uniformed volunteers to augment civilian disaster response and advance public health.MethodsThis report draws on and describes the example of the Texas State Guard’s Medical Brigade and its Operation Lone Star.ResultsAlthough SDFs have downsides, since they are largely self-sufficient, they are far less expensive and burdensome yet nonetheless effective alternatives.ConclusionsFuture avenues for further inquiry are suggested. (Disaster Med Public Health Preparedness. 2017;11:412–416)
Conference on the Teaching of African Languages
Authors: Cowan L. Gray 
Published: February 2017

A small conference was held in New York on March 19 to 20, 1964, concerning the general position of the teaching of African Languages in the United States at the present moment.
The conference, called at the joint request of the National Defense Education Act Language and Area Centers and Columbia University's Institute of African Studies, was attended by the directors and teachers of African language of the major centers of African studies in the United States.
In the course of the two-day meeting the directors reported in some detail on the position of African language teaching in their respective universities and a number of clarifications of NDEA policy were presented by Mr. Donald Bigelow.
The question of a summer session on African languages was discussed at length and a variety of suggestions were offered for possible changes in the format of the existing summer session sponsored by NDEA. In this connection, a resolution was passed urging the establishment of a summer Institute of African Languages, to be located at a permanent site, and under the sponsorship of the African Studies Association.
Materials for African History in the Peabody Museum and Essex Institute
Authors: Bennett Norman R. , Brooks George E. , Booth Alan R. 
Published: February 2017

The city of Salem, Massachusetts, was a major port for American commerce to Africa for much of the nineteenth century. Even in the latter years of the century, when trade had moved to larger centers, the Salem men still played an important role in some African areas.
Due to the efforts of the Peabody Museum and the Essex Institute, many of the papers relating to this American contact with Africa have been preserved. The collections include logbooks of vessels, merchants' account books, and letters to and from agents and captains.
The following pages briefly describe the materials relating to the history of Africa in the archives of the two Salem institutions. The list includes only those items of historical interest. (There are many logs of voyages to Africa of only nautical value.) It attempts to be complete, but no claim is made to having found every document of interest to the historian. Part of the contents of the archives remain uncatalogued and materials relating to Africa are occasionally uncovered under unlikely headings. Research for new sources is being continued.