bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats
Authors: Carvalho Ana Laura O. , Ferri Bárbara G. , de Sousa Francielly A. Lopes , Vilela Fabiana C. , Giusti‐Paiva Alexandre 
Published: July 2016

AbstractSeveral studies have investigated the effects of artificial litter size adjustment on offspring development. Social play behavior is important for neurobehavioral development and is impaired in several developmental psychiatric disorders. This study therefore investigated the effect of litter size on play behavior in adolescent rats. On postnatal day (PND) 2, litters were adjusted to a small litter (SL) size of 3 pups per dam or normal litter (NL) size of 12 pups per dam. Maternal behaviors scored daily during the first week of lactation (PND2‐8) revealed that arched nursing and pup licking behaviors were increased in dams with SLs versus those with NLs. SL offspring exhibited accelerated weight gain and advanced development of physical landmarks and reflexes, possibly due to overnutrition. Social isolation lasting 3.5 h prior to social play behavioral testing produced a higher frequency and duration of pouncing, pinning, sniffing, and grooming in both male and female offspring. However, male SL offspring exhibited a lower frequency of pouncing and pinning when compared with male NL offspring, while no litter size‐dependent differences were observed in social behaviors unrelated to play (sniffing and grooming). These findings identify a possible sexually dimorphic influence of litter size in the development of social behavior. Given that social behaviors such as play behavior are vital for normal cognitive and social development, these findings have important implications for developmental and neuropsychiatric research.
LRG1 mRNA expression in breast cancer associates with PIK3CA genotype and with aromatase inhibitor therapy outcome
Authors: Ramirez-Ardila Diana E. , Ruigrok-Ritstier Kirsten , Helmijr Jean C. , Look Maxime P. , van Laere Steven , Dirix Luc , Berns Els M.J.J. , Jansen Maurice P.H.M. 
Published: July 2016

BackgroundPIK3CA is the most frequent somatic mutated oncogene in estrogen receptor (ER) positive breast cancer. We previously observed an association between PIK3CA genotype and aromatase inhibitors (AI) treatment outcome. This study now evaluates whether expression of mRNAs and miRs are linked to PIK3CA genotype and are independently related to AI therapy response in order to define potential expressed biomarkers for treatment outcome.Materials and methodsThe miR and mRNA expression levels were evaluated for their relationship with the PIK3CA genotype in two breast tumor datasets, i.e. 286 luminal cancers from the TCGA consortium and our set of 84 ER positive primary tumors of metastatic breast cancer patients who received first line AI. BRB Array tools class comparison was performed to define miRs and mRNAs whose expression associate with PIK3CA exon 9 and 20 status. Spearman correlations established miR–mRNA pairs and mRNAs with related expression. Next, a third dataset of 25 breast cancer patients receiving neo‐adjuvant letrozole was evaluated, to compare expression levels of identified miRs and mRNAs in biopsies before and after treatment. Finally, to identify potential biomarkers miR and mRNA levels were related with overall survival (OS) and progression free survival (PFS) after first‐line AI therapy.ResultsExpression of 3 miRs (miR‐449a, miR‐205‐5p, miR‐301a‐3p) and 9 mRNAs (CCNO, FAM81B, LRG1, NEK10, PLCL1, PGR, SERPINA3, SORBS2, VTCN1) was related to the PIK3CA status in both datasets. All except miR‐301a‐3p had an increased expression in tumors with PIK3CA mutations. Validation in a publicly available dataset showed that LRG1, PGR, and SERPINA3 levels were decreased after neo‐adjuvant AI‐treatment. Six miR–mRNA pairs correlated significantly and stepdown analysis of all 12 factors revealed 3 mRNAs (PLCL1, LRG1, FAM81B) related to PFS. Further analyses showed LRG1 and PLCL1 expression to be unrelated with luminal subtype and to associate with OS and with PFS, the latter independent from traditional predictive factors.ConclusionWe showed in two datasets of ER positive and luminal breast tumors that the expression of 3 miRs and 9 mRNAs associate with the PIK3CA status. Expression of LRG1 is independent of luminal (A or B) subtype, decreased after neo‐adjuvant AI‐treatment, and is proposed as potential biomarker for AI therapy outcome.
The impact of supervisor–subordinate relationships and a trainee characteristic upon police officer work outcomes
Authors: Brunetto Yvonne , Teo Stephen , Shacklock Kate , Farr-Wharton Rod , Shriberg Art 
Published: July 2016

AbstractThis study used two theoretical lenses (positive organizational behaviour and social exchange theory) to examine the influence of an individual attribute – psychological capital (PsyCap), and an organizational factor – leader–member exchange, upon police officers’ perceptions of learning options (teamwork and training) and affective commitment. A cross-sectional design using a survey-based, self-report strategy was used to collect data from 588 frontline police officers in the United States. The findings indicate that leader–member exchange explained almost a fifth of PsyCap and together leader–member exchange and PsyCap accounted for almost a third of police officers’ satisfaction with training. Further, leader–member exchange, PsyCap, training and teamwork collectively explain almost half of affective commitment. One implication of the findings is that if senior management want police officers to be more committed, they have to improve officers’ relationships with their supervisors, upskill them (especially their supervisors) in PsyCap, and improve teamwork opportunities and processes.
Self-employment: Deviation or the norm?
Authors: Bridge Simon 
Published: July 2016

AbstractIn many countries self-employment has increased recently. But, despite evidence that many people enter self-employment willingly out of choice, there appears to be an instinctive aversion to it, possibly based on an assumption that employment is more desirable and beneficial and is, and should be, the norm. Often using a UK viewpoint, this paper examines the history of work and suggests that, in historical terms, employment is the exception not the norm. The age of the job, it is claimed, lasted only from 1840 to 1980, but its influence continues and many government regulations and union practices are still based on the era of the big business, big labour and big government triumvirate. Therefore, if the future is not to be constrained by laws and practices designed for the past, it is important to identify the perceptions and assumptions which prevail about employment and to highlight those which are incorrect.
Intracolony variation in colony morphology in reassembled fossil ramose stenolaemate bryozoans from the Upper Ordovician (Katian) of the Cincinnati Arch region, USA
Authors: Key Marcus M. , Wyse Jackson Patrick N. , Felton Stephen H. 
Published: July 2016

AbstractClusters of associated colony fragments discovered weathering out of bedding planes in the Upper Ordovician of the Cincinnati, Ohio, region provide a rare opportunity to quantify intracolony variation in ramose stenolaemate bryozoans. Sixteen colonies were reassembled as completely as possible from 198 fragments, and the following colony-level characters were measured: colony dimensions, branch link length and diameter, and branch order. Results indicate that branch link length and diameter systematically decrease as colonies grow via branch bifurcation. Branching ratio (i.e., the number of distal first-order branches divided by the number of immediately proximal second-order branches) appears to be more genetically than environmentally controlled and to be consistent among orders of stenolaemates and perhaps across the phylum. Colonies with endozones mined out by endoskeletozoans result in broken branches as opposed to pristine growing tips. This varies stratigraphically, perhaps in response to the distribution of the boring animals. The rarity of borers and the systematic proximal increase in branch diameter in these colonies suggest the zooids in the proximal portions of the colonies were alive at the time of colony death. If the time and effort can be invested in reassembling colonies, these morphometric data can then be applied to taxonomic, phylogenetic, and paleoenvironmental studies.
Bag of Tricks: A Set of Techniques and other Resources to Help 14C Laboratory Setup, Sample Processing, and Beyond
Authors: Santos Guaciara M , Xu Xiaomei 
Published: July 2016

AbstractOver the last few decades, radiocarbon laboratories have used different procedures for measuring a broad range of carbonaceous materials. To produce reliable results, the processes employed for sample processing, graphite target production, and spectrometer measurement must be rigorous, well tested, and reproducible. Most of the procedures have been developed, improved, and published as part of the laboratories’ quality control and research programs, and can be frequently found in the literature. Nevertheless, there are suites of laboratory techniques (or “small useful skills”), products, and other resources that either have never been described in publications, or have been somewhat hidden in much larger scientific articles and reports. We feel that with the rapid rise of newer laboratories and facilities, a set of resourceful suggestions might come in handy. Here we gathered these skill sets that can be used in all aspects of 14C sample processing, with the intention to simplify and expedite procedures, from glass-tube making to graphitization and measurements. We also included some miscellaneous items to help in laboratory setup.
An array of sixth abdominal tergite types of paguroid anomurans (Crustacea) from the mid-Cretaceous of Navarra, northern Spain
Authors: Fraaije R.H.B. , Artal P. , van Bakel B.W.M. , Jagt J.W.M. , Klompmaker A.A. 
Published: July 2016

AbstractIn recent years, a range of operculate sixth abdominal tergite types of pylochelid and parapylochelid hermit crabs (Anomura, Paguroidea) have been recorded from Upper Jurassic (Oxfordian and Kimmeridgian) strata in southern Poland and southern Germany. Here we add two new genera (Parapylochelitergites, Paguritergites) and four new late Early Cretaceous species (Parapylochelitergites pustulosus, Pylochelitergites alatus, Pylochelitergites rugosusandPaguritergites yvonnecooleae) from Navarra, northern Spain. In the reefal limestones at Koskobilo quarry near Alsasua, of late Albian age, the number of sixth abdominal paguroid tergite taxa approximates that of paguroid carapace types. Thus, linking fossil paguroid carapaces to tergites can now be attempted. Assemblages of symmetrical hermit crabs (parapylochelids and pylochelids) in reefal settings appear to have changed drastically from the late Albian onwards, with asymmetrical forms (Diogenidae, Paguridae) becoming predominant.
The first North American record of Carinodens belgicus (Squamata, Mosasauridae) and correlation with the youngest in situ examples from the Maastrichtian type area: palaeoecological implications
Authors: Mulder E.W.A. , Formanoy P. , Gallagher W.B. , Jagt J.W.M. , Schulp A.S. 
Published: July 2016

AbstractFour recently collected tooth crowns of the rare latest Cretaceous (late Maastrichtian) durophagous mosasaur Carinodens belgicus are discussed; the first record from the Atlantic coast of North America (Maryland), and three additional in situ examples from the Maastrichtian type area in the southeast Netherlands and northeast Belgium. Also presented are an updated overview of the material recorded to date, and a discussion of the palaeobiogeographical and palaeoenvironmental distribution of the genus. Towards the end of the Cretaceous, Carinodens appears to have been successful in exploiting the margins of both the proto-Atlantic Ocean and the Tethyan Realm.
Bone damage in Allopleuron hofmanni (Cheloniidae, Late Cretaceous)
Authors: Janssen R. , van Baal R.R. , Schulp A.S. 
Published: July 2016

AbstractWe describe pathologies and post-mortem damage observed in specimens of the late Maastrichtian marine cheloniid turtle Allopleuron hofmanni. Shallow circular lesions on carapace bones are common and possibly illustrate barnacle attachment/embedment. Deep, pit-like marks are confined to the neural rim and the inner surface of peripheral elements; these may have been caused either by barnacle attachment or disease. A number of linear marks found on outer carapace surfaces are identified as tooth marks of scavengers, others as possible domichnia of boring bivalves. A fragmentary scapula and prescapular process displays radular traces of molluscs (gastropods and/or polyplacophorans; ichnogenus Radulichnus). These diverse types of bone damage suggest both live and dead marine turtles to have been commonly utilised by predators, scavengers and encrusters in the type Maastrichtian marine ecosystem.
On diving and diet: resource partitioning in type-Maastrichtian mosasaurs
Authors: Schulp A.S. , Vonhof H.B. , van der Lubbe J.H.J.L. , Janssen R. , van Baal R.R. 
Published: July 2016

AbstractThe carbon isotope composition of tooth enamel from all five mosasaur taxa known to date from the type Maastrichtian (southeast Netherlands, northeast Belgium) has been analysed. Differences in enamel δ13C values between taxa suggest resource partitioning. Body size and δ13C value correlate surprisingly well, with larger taxa having δ13C values more depleted in the heavier 13C isotope.
Tracking consolidant penetration into fossil bone using neutron radiography
Authors: Schulp A.S. , Schouten R. , Metten L. , van de Sande A. , Bontenbal A. 
Published: July 2016

AbstractIn the conservation of fragile fossil bone material, impregnation by solvent-borne consolidant is often required. Understanding the mode of penetration of consolidants into fossil bone is of crucial importance. It is governed by a variety of factors; neutron imaging is a powerful tool to monitor and visualise this penetration (non-destructively). The consolidation of a vertebrate fossil from the Maastrichtian of the southeast Netherlands was imaged at the High Flux Reactor facility at Petten, the Netherlands. The analysis shows current conservation practice to result in a sufficiently deep and isotropic penetration.
A bifacial tool of the Neanderthals from Ameland, the Netherlands
Authors: Stapert D. , Johansen L. , Niekus M.J.L.Th. 
Published: July 2016

AbstractA bifacially worked flint tool has recently been found on the North Sea beach of Ameland, one of the Wadden Islands in the northern Netherlands. It probably dates from the Middle Palaeolithic because its surface modifications include windgloss which in this area originated especially during the Weichselian Late Pleniglacial. The tool was probably first worked by a skilled knapper and subsequently, after a break occurred, by an apprentice. It is suggested that the tool was transported to Ameland from the North Sea bottom in the course of sand replenishment activities. Other artefacts from the Wadden Islands allegedly left by Neanderthals are also briefly discussed.
Two rare mosasaurs from the Maastrichtian of Angola and the Netherlands
Authors: Schulp A.S. , Polcyn M.J. , Mateus O. , Jacobs L.L. 
Published: July 2016

AbstractWe report here the addition of two rare mosasaur taxa to the Maastrichtian marine amniote fauna of Angola, both of which are also found in northern Europe. The new specimens include a dentary fragment referable to the large carnivorePrognathodoncf.saturatorand an isolated tooth of the small durophageCarinodens belgicus. Both were recovered from Maastrichtian outcrops in southern Angola in 2011. Additionally, a complete posterior mandibular unit of a large mosasaur from the type Maastrichtian of the Netherlands, collected some time prior to 1879 and previously identified as ‘Mosasaurus giganteus’, is described and reassigned here toPrognathodon saturator; historical issues surrounding the taxonomic attribution of this specimen are clarified. The new material extends the known geographic distribution ofPrognathodon saturatorandCarinodens belgicus.
The Roman Limes in the Netherlands: how a delta landscape determined the location of the military structures
Authors: van Dinter M. 
Published: July 2016

AbstractFrom the 40s A.D. onwards a dense military system was established in the Lower Rhine delta in the Netherlands. Long since, it is questioned why this system was established in a wetland area and even turned into the northwest frontier of the Roman Empire, theLimes. A new detailed palaeogeographical map, based on a digital elevation model (LIDAR), soil maps and excavation results, was constructed. This reconstruction provides insight and understanding of the interactions between the natural environment in this part of the delta on the one hand and the establishment of this part of theLimesalong the Old Rhine between Utrecht and Katwijk on the other. This study shows that the distinctive landscape of the western Rhine-Meuse delta, with an exceptionally large number of tributaries, determined the spatial pattern of the military structures. All forts (castella) were erected on the southern natural levees of the river Rhine, directly alongside the river, regardless of height and composition of the subsoil and alongside or opposite routes that provided natural access to the river. We conclude that their aim was to guard all waterways that gave access to the river Rhine from the Germanic residential areas further north and from/to the Meuse tributary further south in the delta. In addition, a system of small military structures, mostly watchtowers, was erected between the forts to watch over the river Rhine and its river traffic. Furthermore, at least two canals were established to create shorter and safely navigable transport routes to the river Meuse. At first, this integrated system of castella and watchtowers probably aimed to protect against Germanic invasions and to create a safe corridor for transport and built up of army supplies for the British invasion in 43 A.D. Only later on, probably by the end of the first century, this corridor turned into a frontier zone.
Probable remains of jellyfish (Cnidaria, Scyphozoa) from the lower Middle Triassic (Anisian) of Winterswijk, eastern Netherlands
Authors: Oosterink H.W. , Winkelhorst H. 
Published: July 2016

AbstractDuring recent years, regular round structures have been collected from the top of Bed 12 of the Vossenveld Formation (Lower Muschelkalk, lower Middle Triassic, Anisian) in the Winterswijk area, eastern Netherlands. These are here illustrated and described as probable remains of jellyfish.
Reconstruction of burial history, temperature, source rock maturity and hydrocarbon generation in the northwestern Dutch offshore
Authors: Fattah R. Abdul , Verweij J.M. , Witmans N. , ten Veen J.H. 
Published: July 2016

Abstract3D basin modelling is used to investigate the history of maturation and hydrocarbon generation on the main platforms in the northwestern part of the offshore area of the Netherlands. The study area covers the Cleaverbank and Elbow Spit Platforms. Recently compiled maps and data are used to build the input geological model. An updated and refined palaeo water depth curve and newly refined sediment water interface temperatures (SWIT) are used in the simulation. Basal heat flow is calculated using tectonic models. Two main source rock intervals are defined in the model, Westphalian coal seams and pre-Westphalian shales, which include Namurian and Dinantian successions. The modelling shows that the pre-Westphalian source rocks entered the hydrocarbon generation window in the Late Carboniferous. In the southern and central parts of the study area, the Namurian started producing gas in the Permian. In the north, the Dinantian source rocks appear to be immature. Lower Westphalian sediments started generating gas during the Upper Triassic. Gas generation from Westphalian coal seams increased during the Paleogene and continues in present-day. This late generation of gas from Westphalian coal seams is a likely source for gas accumulations in the area.Westphalian coals might have produced early nitrogen prior to or during the main gas generation occurrence in the Paleogene. Namurian shales may be a source of late nitrogen after reaching maximum gas generating phase in the Triassic. Temperatures reached during the Mid Jurassic were sufficiently high to allow the release of non-organic nitrogen from Namurian shales.
Late Cenozoic shelf delta development and Mass Transport Deposits in the Dutch offshore area – results of 3D seismic interpretation
Authors: Benvenuti A. , Kombrink H. , ten Veen J.H. , Munsterman D.K. , Bardi F. , Benvenuti M. 
Published: July 2016

AbstractIn this study, seismic stratigraphic criteria have been used to characterise the evolution of the Southern North Sea (SNS) shelf-delta system that progressively filled the Southern North Sea basin during Plio-Pleistocene times. Based on the prograding and down-stepping architecture of the shelf-delta sequence it is inferred that deposition occurred during a time of high sediment supply and overall sea-level lowering. During this time the delta slopes failed several times, creating at least 30 internally coherent Mass Transport Deposits (MTDs) mainly grouped in common areas, affecting the same clinoform set and partially sharing the basal shear surface (groups of MTDs). The most important features of the studied MTDs are 1) the dominance of brittle deformation; 2) the small amount of material removal from the headwall domain (lack of completely depleted areas above the basal shear surface); and 3) the lack of an emergent toe domain above the un-failed sediment located basinward, although proper confining geometries for the MTD are not detected. Therefore, the studied MTDs can neither be classified as frontally confined nor as frontally emergent but they are a new intermediate type of submarine landslides which has not been described before. These characteristics suggest that the mass movement ceased relatively soon after initiation of failure. Incisions on top of the MTDs suggest the presence of erosive flows. These flows were probably generated due to a concentration of the drainage in the negative morphology the failure event left behind in the upper sector of the slope. The stronger progradational character of the reflections on top of MTDs confirms a concentration of drainage after the erosional phase too.The interplay between high sediment supply and constant or even decreasing accommodation space (caused by constant or decreasing sea-level) is supposed to be the main precondition for slope instability for most of the MTDs in this study area. Slope failures themselves can also be considered a preconditioning factor by the creation of local very high sedimentation rates (see groups of MTDs). Salt-induced seismicity and storm waves' effect superimposed on high frequency sea level fall are considered the most important triggering factors.