bluuebunny/crossref_metadata_2025_split huggingface dataset:
Potentiels et enjeux de l’intervention par texto : l’expérience de Tel-jeunes au Québec
Authors: Thoër Christine , Noiseux Kathia , Siche Fabienne , Palardy Caroline , Vanier Claire , Vrignaud Caroline 
Published: June 2017

En 2013, Tel-jeunes s’est doté d’un nouveau mode d’intervention brève par texto pour rejoindre les jeunes âgés de 12 à 17 ans. Ce type d’intervention psychosociale assuré par un intervenant professionnel constituait une première au Québec. Tel-jeunes a engagé une recherche visant à : 1) cerner les motivations et les types de problématiques qui amènent les jeunes à utiliser le service ; 2) documenter les spécificités de l’intervention brève par texto ; 3) identifier les avantages et les difficultés rencontrées par les intervenants. Nous avons opté pour une stratégie méthodologique mixte mobilisant 3 modes de collecte des données soit 4 groupes focus avec des jeunes âgés de 15 à 17 ans, 2 groupes focus avec 11 intervenants et une analyse de contenu d’un corpus de 13 236 textos. Nos résultats montrent que le service texto répond à un besoin de communication des jeunes et qu’il permet de rejoindre une nouvelle clientèle. Trois thématiques dominent dans les demandes qui émanent très largement des filles, soit les relations amoureuses, la santé psychologique et la sexualité. Les jeunes attribuent de nombreux avantages au service texto, entre autres, l’anonymat, la possibilité de texter en tout temps et le caractère réflexif de l’écrit. Les intervenants jugent ce mode d’intervention efficace et satisfaisant pour répondre aux demandes d’information des jeunes, mais rapportent des difficultés lors d’interventions sur des problématiques plus complexes. Celles-ci renvoient aussi au mode de communication par texto, aux limites de la plateforme web et à l’organisation du travail. Plusieurs ajustements ont permis d’améliorer l’expérience d’intervention.
The comparative osteology ofPlesiochelys biglerin. sp., a new coastal marine turtle from the Late Jurassic of Porrentruy (Switzerland)
Authors: Püntener Christian , Anquetin Jérémy , Billon-Bruyat Jean-Paul 
Published: June 2017

BackgroundDuring the Late Jurassic, several groups of eucryptodiran turtles inhabited the shallow epicontinental seas of Western Europe. Plesiochelyidae are an important part of this first radiation of crown-group turtles into coastal marine ecosystems. Fossils of Plesiochelyidae occur in many European localities, and are especially abundant in the Kimmeridgian layers of the Swiss Jura Mountains (Solothurn and Porrentruy). In the mid-19th century, the quarries of Solothurn (NW Switzerland) already provided a large amount of fossil turtles, most notablyPlesiochelys etalloni, the best-known plesiochelyid species. Recent excavations in the Porrentruy area (NW Switzerland) revealed new fossils ofPlesiochelys, including numerous well-preserved shells with associated cranial and postcranial material.Methods/resultsOut of 80 shells referred toPlesiochelys, 41 are assigned to a new species,Plesiochelys biglerin. sp., including a skull–shell association. We furthermore refer 15 shells toPlesiochelys etalloni, and 24 shells toPlesiochelyssp. Anatomical comparisons show thatPlesiochelys biglerican clearly be differentiated fromPlesiochelys etalloniby cranial features. The shell anatomy and the appendicular skeleton ofPlesiochelys bigleriandPlesiochelys etalloniare very similar. However, a statistical analysis demonstrates that the thickness of neural bones allows to separate the two species based on incomplete material. This study furthermore illustrates the extent of intraspecific variation in the shell anatomy ofPlesiochelys bigleriandPlesiochelys etalloni.
Ethnobotany of Plants in Tagkawayan: Input for Information Communication Media on Medicinal Uses of Plants
Authors: Favor Cherry C. 
Published: June 2017

In the Philippine countryside, where barrio folks are closely entwined with their natural environment, their close contact especially to the adjoin dipterocarp forests makes them more knowledgeable on the different uses of plants. This study focuses on the exploration of the traditional knowledge of plants more specifically on its medicinal uses. An enhanced and adapted semi structure interview guide was employed and a qualitative approach was incorporated in data gathering. The study recorded a total of 136 plant species of which 52% (81 species) were of medicinal uses, the foremost plant part used were the leaves (58%), route of administration was internal application (67%) and the most commonly method of preparation is boiling (58%). The dosage frequently given was 3x a day. Results showed a rich diversity of plant species in Tagkawayan and the barrio folks are knowledgeable on the traditional uses of plants, but this knowledge were not yet explored because these are trapped among older generation that are transferred through verbal means. Development of a reading material will be of great help for preservation and information dissemination of these beneficial uses of plants. The use of leaves is an indication that the biodiversity in the place is ensured and continued reliance on the use of herbal plant showed that plants could be a better alternative for synthetic drugs in treatment of common diseases.
ANÁLISE DE ATIVIDADES DE LEITURA DO LIVRO DIDÁTICO "PROJETO TELÁRIS PORTUGUÊS OITAVO ANO"
Authors: Hogetop Mônica , Poutou Fidele 
Published: June 2017

Neste artigo, pretendemos analisar atividades de leitura propostas em um capítulo de um livro didático que tem como eixo norteador a teoria dos gêneros e como um de seus diferenciais o trabalho com projetos de leitura. Para isso, mobilizamos concepções de leitura a partir de Busnardo e Braga (2000); Paulo Freire (1994); Cavalcanti (2011); Geraldi (1988); Leffa (1999) e outros através de uma pesquisa qualitativa, de abordagem interpretativista e de cunho bibliográfico e documental. Com o intuito de analisar cada uma das atividades, discutimos as diversas concepções de leitura, relacionando-as com as presentes na abordagem adotada pelos autores do livro. Como resultado, observamos que, embora os autores afirmem partir de uma abordagem sócio construtivista, o fazem de forma equivocada. Como foi possível relacionar várias concepções de leitura às atividades listadas, concluímos que o professor que adote tal livro didático, pode propor variações através das demais perspectivas de acordo com seus objetivos de ensino. Palavras-chave: Gênero textual. Leitura. Livro didático.
A global lightning parameterization based on statistical relationships among environmental factors, aerosols, and convective clouds in the TRMM climatology
Authors: Stolz Douglas C. , Rutledge Steven A. , Pierce Jeffrey R. , van den Heever Susan C. 
Published: June 2017

AbstractThe objective of this study is to determine the relative contributions of normalized convective available potential energy (NCAPE), cloud condensation nuclei (CCN) concentrations, warm cloud depth (WCD), vertical wind shear (SHEAR), and environmental relative humidity (RH) to the variability of lightning and radar reflectivity within convective features (CFs) observed by the Tropical Rainfall Measuring Mission (TRMM) satellite. Our approach incorporates multidimensional binned representations of observations of CFs and modeled thermodynamics, kinematics, and CCN as inputs to develop approximations for total lightning density (TLD) and the average height of 30 dBZradar reflectivity (AVGHT30). The results suggest thatTLD and AVGHT30 increase with increasing NCAPE,increasing CCN,decreasing WCD,increasing SHEAR,and decreasing RH. Multiple‐linear approximations for lightning and radar quantities using the aforementioned predictors account for significant portions of the variance in the binned data set (R2 ≈ 0.69–0.81). The standardized weights attributed to CCN, NCAPE, and WCD are largest, the standardized weight of RH varies relative to other predictors, while the standardized weight for SHEAR is comparatively small. We investigate these statistical relationships for collections of CFs within various geographic areas and compare the aerosol (CCN) and thermodynamic (NCAPE and WCD) contributions to variations in the CF population in a partial sensitivity analysis based on multiple‐linear regression approximations computed herein. A global lightning parameterization is developed; the average difference between predicted and observed TLD decreases from +21.6 to +11.6% when using a hybrid approach to combine separate approximations over continents and oceans, thus highlighting the need for regionally targeted investigations in the future.
Line radiation events induced by very low frequency transmitters observed by the DEMETER spacecraft
Authors: Němec F. , Čížek K. , Parrot M. , Santolík O. , Záhlava J. 
Published: June 2017

AbstractElectromagnetic wave data measured by the low‐altitude Detection of Electro‐Magnetic Emissions Transmitted from Earthquake Regions (DEMETER) spacecraft sometimes exhibit intense emissions at discrete, harmonically spaced frequencies. We present a comprehensive analysis of this type of phenomenon, and we demonstrate that it is caused by very low frequency (VLF) transmitters in Europe. All available data were investigated for a possible presence of the events. Altogether, 87 events were identified, occurring exclusively during the nighttime. The occurrence of the events does not show any clear relation to the AE and Dst geomagnetic activity indices. The events are clearly localized, occurring either close to Great Britain or in the vicinity of its geomagnetically conjugated region. The frequency spectra of the events typically consist of up to four spectral peaks at multiples of about 1.3 kHz. Additional weaker spectral peaks at frequencies of about 1.9 kHz and 3.2 kHz are occasionally present. The events observed in the Northern Hemisphere tend to have larger‐frequency bandwidths than the events observed in the Southern Hemisphere. The occurrence of these events is correlated with the simultaneous detection of signals from VLF transmitters. A bicoherence analysis is employed to demonstrate that wave‐wave coupling takes place. Finally, it is shown that the occurrence of the events is associated with a significantly increased precipitation of energetic electrons in a wide range of energies.
Sonographic diagnosis of mid‐aortic syndrome in a 2‐year‐old patient with hypertension
Authors: Thomas Shannon D. , Bourke Victor C. , Varcoe Ramon L. , Weaver Kaylea , Lennox Andrew 
Published: June 2017

AbstractMid‐aortic syndrome is a rare cause of hypertension in the paediatric population. We present here the sonographic findings of a 2 year old who presented with hypertension. Mid‐aortic syndrome was diagnosed upon finding renal artery and infrarenal aortic stenoses on ultrasound. The clinical entity and interrogation of the paediatric renal and aortic vessels are discussed.
A Membrane‐Free Redox Flow Battery with Two Immiscible Redox Electrolytes
Authors: Navalpotro Paula , Palma Jesus , Anderson Marc , Marcilla Rebeca 
Published: June 2017

AbstractFlexible and scalable energy storage solutions are necessary for mitigating fluctuations of renewable energy sources. The main advantage of redox flow batteries is their ability to decouple power and energy. However, they present some limitations including poor performance, short‐lifetimes, and expensive ion‐selective membranes as well as high price, toxicity, and scarcity of vanadium compounds. We report a membrane‐free battery that relies on the immiscibility of redox electrolytes and where vanadium is replaced by organic molecules. We show that the biphasic system formed by one acidic solution and one ionic liquid, both containing quinoyl species, behaves as a reversible battery without any membrane. This proof‐of‐concept of a membrane‐free battery has an open circuit voltage of 1.4 V with a high theoretical energy density of 22.5 Wh L−1, and is able to deliver 90 % of its theoretical capacity while showing excellent long‐term performance (coulombic efficiency of 100 % and energy efficiency of 70 %).
Putative gravisensors among microtubule associated proteins
Authors: Shevchenko Galina V. 
Published: June 2017

AbstractDespite of long period of investigation (over 100 years), still a lot of questions remain unclear about molecular mechanisms of plant graviperception. This requires designing new experiments and new approaches to be applied in gravitational biology. Investigation of plant cell reactions under clinorotation (plant disorientation in respect to gravity vector) is of significant importance to such type of research. Clinorotation is known to cause changes of cell polarity and exert mechanical stress in plant cells. Microtubular cytoskeleton is highly dynamic structure and it responds to both of these stresses. Due to turgor pressure and cell elongation, endogenous mechanical forces influence microtubule orientation in order to coordinate cell growth. Rearrangements of microtubules are regulated by numerous associated proteins which functional activity is not fully clear. In this review, we discuss how MT associated proteins regulate cortical MT arrays under mechanical stress and consider how these proteins may act as plant cell gravisensors. Investigation of microtubule associated proteins under clinorotation might shed the light on molecular mechanism of plant cytoskeleton arrangement and its involvement in initial reactions of cell graviperception.
Excessive homozygosity identified by chromosomal microarray at a known GCDH mutation locus correlates with brain MRI abnormalities in an infant with glutaric aciduria
Authors: Peer‐Zada Abdul Ali , Al‐Asmari Ali M. 
Published: June 2017

Key Clinical MessageHerein, we report a conceptually novel clinical case highlighting the diagnostic implications of excessive homozygosity and its correlation with brain MRI abnormalities in an infant with GA1. The case also points a need for an extra amount of caution to be exercised when evaluating patients with “negative exomes.”
Unexpected Importance of Aromatic–Aliphatic and Aliphatic Side Chain–Backbone Interactions in the Stability of Amyloids
Authors: Ninković Dragan B. , Malenov Dušan P. , Petrović Predrag V. , Brothers Edward N. , Niu Shuqiang , Hall Michael B. , Belić Milivoj R. , Zarić Snežana D. 
Published: June 2017

AbstractThe role of aromatic and nonaromatic amino acids in amyloid formation has been elucidated by calculating interaction energies between β‐sheets in amyloid model systems using density functional theory (B3LYP‐D3/6‐31G*). The model systems were based on experimental crystal structures of two types of amyloids: (1) with aromatic amino acids, and (2) without aromatic amino acids. Data show that these two types of amyloids have similar interaction energies, supporting experimental findings that aromatic amino acids are not essential for amyloid formation. However, different factors contribute to the stability of these two types of amyloids. In the former, the presence of aromatic amino acids significantly contributes to the strength of interactions between side chains; interactions between aromatic and aliphatic side chains are the strongest, followed by aromatic–aromatic interactions, while aliphatic–aliphatic interactions are the weakest. In the latter, that is, the amyloids without aromatic residues, stability is provided by interactions of aliphatic side chains with the backbone and, in some cases, by hydrogen bonds.
Cancer Stem Cell and Bulk Cancer Cell Active Copper(II) Complexes with Vanillin Schiff Base Derivatives and Naproxen
Authors: Lu Chunxin , Eskandari Arvin , Cressey Paul B. , Suntharalingam Kogularamanan 
Published: June 2017

AbstractFour copper(II) complexes, 1–4 containing regioisomeric vanillin Schiff base derivatives and the nonsteroidal anti‐inflammatory drug (NSAID), naproxen, were synthesised and characterised. All complexes effectively cleave DNA in cell‐free systems, with 4 displaying the highest nuclease activity. DNA binding studies suggest that 4 binds to DNA via the grooves prior to inducing oxidative DNA cleavage. Three of the complexes (1, 3, and 4) indiscriminately kill cancer stem cell (CSC)‐enriched cells (HMLER‐shEcad) and bulk cancer cells (HMLER) at micromolar concentrations. The most effective complex, 4 also reduced the formation and size of mammospheres to a similar extent as salinomycin, a well‐established CSC‐potent agent. Mechanistic studies show that 4 is readily taken up by CSCs, elevates intracellular reactive oxygen species (ROS) levels, causes DNA damage, and induces caspase‐dependent apoptosis. Furthermore, 4 inhibits cyclooxygenase‐2 (COX‐2) expression and causes COX‐2‐dependent CSC death. The advantage of 4 over bulk cancer cell‐ or CSC‐selective agents is that it has the potential to remove whole tumor populations (bulk cancer cells and CSCs) with a single dose.
Synthesis, Characterization, and Electrochemistry of Open‐Chain Pentapyrroles and Sapphyrins with Highly Electron‐Withdrawing meso‐Tetraaryl Substituents
Authors: Shan Wenqian , Desbois Nicolas , Blondeau‐Patissier Virginie , Naitana Mario L. , Quesneau Valentin , Rousselin Yoann , Gros Claude P. , Ou Zhongping , Kadish Karl M. 
Published: June 2017

AbstractA series of open‐chain pentapyrroles and sapphyrins with highly electron‐withdrawing substituents (i.e., CN, CF3, or CO2Me) on the meso‐phenyl rings was synthesized and characterized as to the spectral properties, protonation reactions, and electrochemistry in non‐aqueous media. The investigated compounds are represented as (Ar)4PPyH3 and (Ar)4SapH3 where PPy and Sap correspond to the tri‐anion of the open‐chain pentapyrrole and sapphyrin, respectively, and Ar=p‐CNPh, p‐CF3Ph, or p‐CO2MePh. UV/Vis and 1H NMR spectroscopy as well as mass spectrometry data are given for the confirmation of the structures for the newly synthesized compounds. An X‐ray structure for one of the pentapyrroles, that is, (p‐CF3Ph)4PPyH3 (2), is also presented. The protonation processes were examined by UV/Vis absorption spectroscopy during the titration of the compounds with trifluoroacetic acid (TFA) in CH2Cl2. Equilibrium constants for the protonation reactions were calculated by using both the Hill equation and the mole ratio method. The protonation‐initiated conversion of pentapyrroles to sapphyrins upon oxidation was also investigated. Cyclic voltammetry was used to measure the redox potentials in CH2Cl2, PhCN, and/or pyridine (Py). Electrochemical properties, protonation constants, and chemical reactions of the six compounds in the two series were then analyzed as a function of the solvent properties and the type of the electron‐withdrawing groups on the meso‐phenyl rings.
Room‐Temperature Columnar Nematic and Soft Crystalline Columnar Assemblies of a New Series of Perylene‐Centred Disc Tetramers
Authors: Bala Indu , Gupta Santosh Prasad , De Joydip , Pal Santanu Kumar 
Published: June 2017

AbstractThree new oligomeric perylene (PE) tetraester derivatives, consisting of a PE‐based core with four pentaalkynylbenzene units attached through flexible alkyl spacers, are reported. These derivatives were investigated for their mesomorphic properties and thermal, photophysical, and electrochemical behaviour. Small‐ (SAXS) and wide‐angle X‐ray scattering (WAXS) studies were performed to deduce the exact nature of the phases. To resolve overlapping reflections and facilitate their indexing, grazing‐incidence SAXS/WAXS experiments were carried out on oriented thin films on indium tin oxide (ITO)‐coated glass substrate. The corresponding electron density maps were derived from the intensities observed in the diffraction pattern. Whereas compounds with shorter alkyl spacers (n=6 and 8) were found to self‐organise into soft crystalline columnar assemblies, those with longer spacers (n=10) exhibited a liquid‐crystalline columnar nematic mesophase. This is in contrast to previous reports that describe highly symmetric 2D hexagonal and rectangular columnar structures of PE‐based mesogens. The morphology of self‐assembly was found to transform from soft crystal columnar to nematic columnar phase through simple variation in the number of alkyl spacers. All compounds exhibited excellent fluorescence emission properties with a very good quantum yield and large band gap. Apart from high solubility and good quantum yield, these compounds can serve as standards to measure quantum yields of unknown samples. These compounds also display green luminescence and may find applications for various optoelectronic devices.
Mechanism and Origins of the Chemo‐ and Regioselectivities in Nickel‐Catalyzed Intermolecular Cycloadditions of Benzocyclobutenones with 1,3‐Dienes
Authors: Zou Hongyan , Wang Zhong‐Liang , Huang Genping 
Published: June 2017

AbstractThe nickel‐catalyzed intermolecular cycloadditions of benzocyclobutenones with 1,3‐dienes developed by Martin and co‐workers are featured with the exclusive proximal C−C bond cleavage and a high chemoselectivity of the [4+4] over the [4+2] cycloaddition. In this report, the detailed reaction mechanism and the origins of the selectivities were investigated by means of density functional theory calculations. The results show that the reaction is initiated by a C−C oxidative addition of the benzocyclobutenone to form the five‐membered nickelacycles. A subsequent exo 1,4‐insertion/C−C reductive elimination and an endo 1,4‐insertion/C−C reductive elimination lead to the [4+4] and [4+2] cycloaddition products, respectively. The 1,4‐insertion of the 1,3‐diene into the Ni−C bond was calculated to be the rate‐ and selectivity‐determining step of the reaction. The calculations reproduced quite well the experimentally observed exclusive proximal C−C bond cleavage and the high chemoselectivity of the [4+4] over the [4+2] cycloaddition. In particular, it was found that the steric repulsion between the phosphine ligand and the α‐substituent of the benzocyclobutenone has a dramatic impact on the 1,4‐insertion, which enables the experimentally observed selectivities.
Monosynaptic retrograde tracing of neurons expressing the G‐protein coupled receptor Gpr151 in the mouse brain
Authors: Broms Jonas , Grahm Matilda , Haugegaard Lea , Blom Thomas , Meletis Konstantinos , Tingström Anders 
Published: June 2017

AbstractGPR151 is a G‐protein coupled receptor for which the endogenous ligand remains unknown. In the nervous system of vertebrates, its expression is enriched in specific diencephalic structures, where the highest levels are observed in the habenular area. The habenula has been implicated in a range of different functions including behavioral flexibility, decision making, inhibitory control, and pain processing, which makes it a promising target for treating psychiatric and neurological disease. This study aimed to further characterize neurons expressing the Gpr151 gene, by tracing the afferent connectivity of this diencephalic cell population. Using pseudotyped rabies virus in a transgenic Gpr151‐Cre mouse line, monosynaptic afferents of habenular and thalamic Gpr151‐expressing neuronal populations could be visualized. The habenular and thalamic Gpr151 systems displayed both shared and distinct connectivity patterns. The habenular neurons primarily received input from basal forebrain structures, the bed nucleus of stria terminalis, the lateral preoptic area, the entopeduncular nucleus, and the lateral hypothalamic area. The Gpr151‐expressing neurons in the paraventricular nucleus of the thalamus was primarily contacted by medial hypothalamic areas as well as the zona incerta and projected to specific forebrain areas such as the prelimbic cortex and the accumbens nucleus. Gpr151 mRNA was also detected at low levels in the lateral posterior thalamic nucleus which received input from areas associated with visual processing, including the superior colliculus, zona incerta, and the visual and retrosplenial cortices. Knowledge about the connectivity of Gpr151‐expressing neurons will facilitate the interpretation of future functional studies of this receptor.