bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reducing alcohol-related interpretation biases in young hazardous drinkers by Cognitive Bias Modification–Interpretation Training
Authors: Hutschemaekers Moniek H. M. , Woud Marcella L. , Becker Eni S. , Rinck Mike 
Published: January 2017

Abstract. Aims: This study examined whether alcohol-related interpretation biases (IBs) can be reduced by means of cognitive bias modification – interpretation (CBM-I) training. Also, the training’s generalization effects and the moderating role of executive control (EC) were examined. Methods: Participants were 98 young hazardous drinkers. Half of the participants were trained to interpret ambiguous alcohol-related scenarios in an alcohol-unrelated way (neutral CBM-I), the other half completed alcohol-related ambiguous open-ended scenarios (control CBM-I). Alcohol-related IBs were assessed with open-ended ambiguous alcohol-related scenarios, completed by participants. The completions were coded by participants (self-coding) and by two independent coders (conservatively and liberally). Results: Neutral CBM-I, compared to control CBM-I, did not decrease alcohol-related IBs for the conservative and self-coding. For the liberal coding, both groups showed a decrease in alcohol-related IBs pre to post training. Moreover, there were no group differences in interpreting ambiguous, alcohol-related pictures during a signal-detection task. At the behavioral level, there was no reduction in alcohol use for either group at one week follow-up. Finally, EC did not moderate training effects. Conclusions: Although CBM-I effects were largely absent; the findings emphasize that more research into the working mechanisms of alcohol CBM-I is needed to test its potential in the context of hazardous drinking.
Schulisches Wohlbefinden, Schulform und Tabakkonsum von Jugendlichen: Ergebnisse der SILNE-Studie
Authors: Rathmann Katharina , Heilmann Kristina , Moor Irene , Richter Matthias 
Published: January 2017

Zusammenfassung. Zielsetzung: Der Beitrag untersucht die Bedeutung der besuchten Schulform und des schulischen Wohlbefindens für den Tabakkonsum von Jugendlichen und prüft erstmals, ob sich dieser Zusammenhang im Sinne einer doppelten Benachteiligung auf den Tabakkonsum auswirkt. Methodik: Datenbasis bildet der deutsche Survey der europäischen SILNE-Studie „Tackling socioeconomic inequalities in smoking: learning from natural experiments by time trend analyses and cross-national comparisons“ (Schüler der 8. und 9. Klasse) in Hannover (n = 1.190). In bi- und multivariaten Analysen werden die Zusammenhänge zwischen den Merkmalen des schulischen Wohlbefindens (Schulengagement, Schulverbundenheit und Burnout), der besuchten Schulform und dem Tabakkonsum überprüft. Ergebnisse: Jugendliche mit niedrigem Schulengagement, geringer Schulverbundenheit sowie erhöhtem schulbezogenen Burnout zeigen eine erhöhte Wahrscheinlichkeit zu rauchen, ebenso wie Schüler, die eine andere Schulform als das Gymnasium besuchen. Belege der doppelten Benachteiligung für den Tabakkonsum von Jugendlichen konnten nicht gefunden werden. Gymnasiasten besitzen im Vergleich zu Schülern anderer Schulformen eine erhöhte Wahrscheinlichkeit zu rauchen, wenn sie über schulbezogenes Burnout berichten. Schlussfolgerungen: Unsere Ergebnisse geben wichtige Hinweise für schulformspezifische Maßnahmen der Gesundheitsförderung, um das schulische Wohlbefinden zu fördern und dem Tabakkonsum im Jugendalter entgegenzuwirken.
Johnson, Lozier, Meltzer, and Oreskes Receive 2016 Ambassador Awards
Authors:   AGU
Published: December 2016

Ashanti Johnson, M. Susan Lozier, Anne S. Meltzer, and Naomi Oreskes were awarded the 2016 Ambassador Award at the American Geophysical Union Fall Meeting Honors Ceremony, held on 14 December 2016 in San Francisco, Calif. The award is in recognition for "outstanding contributions to one or more of the following area(s): societal impact, service to the Earth and space community, scientific leadership, and promotion of talent/career pool."
Enhanced expression of Survivin has distinct roles in adipocyte homeostasis
Authors: Ju Liping , Zhang Xiaoyan , Deng Yujie , Han Junfeng , Yang Jian , Chen Shuqin , Fang Qichen , Yang Ying , Jia Weiping 
Published: January 2017

AbstractAlthough precisely controlled lipolysis is crucial for maintaining physiological levels of circulating free fatty acids in response to energetic stress, the underlying mechanisms by which this process is governed remain poorly understood. Survivin is a gene that has been found to be highly expressed in the most common human tumors, and it is considered to be associated with tumorigenesis. Survivin expression in normal tissue is developmentally downregulated and is undetectable in most terminally differentiated adult tissues. Here, we report that Survivin expression in mature adipocytes from murine white adipose tissue can be highly induced under high-fat diet feeding conditions. During the adipocyte differentiation of 3T3-L1 preadipocytes and mesenchymal C3H10T1/2 cells, Survivin expression is gradually decreased and almost undetectable in fully differentiated adipocytes. However, it can be expressed again upon insulin exposure, through the PI3K/mTOR signaling pathway. Nevertheless, Survivin overexpression is sensitive to nutritional deprivation, and expression markedly decreases in response to starvation with Hank’s buffered salt solution challenge. The ectopic expression of Survivin downregulates expression of Adrb3 and then decreases the production of cAMP, while Fsp27 protein levels are upregulated as a result of reduced protein degradation. This in turn inhibits isoproterenol-stimulated adipocyte lipolysis. Survivin also attenuates DNA damage related to PARP activation and inhibits TNFα-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli. Further studies will be undertaken to determine whether Survivin is critical for lipid storage to maintain metabolic homeostasis in vivo.
Temporal coherence structure rapidly shapes neuronal interactions
Authors: Lu Kai , Xu Yanbo , Yin Pingbo , Oxenham Andrew J. , Fritz Jonathan B. , Shamma Shihab A. 
Published: January 2017

AbstractPerception of segregated sources is essential in navigating cluttered acoustic environments. A basic mechanism to implement this process is the temporal coherence principle. It postulates that a signal is perceived as emitted from a single source only when all of its features are temporally modulated coherently, causing them to bind perceptually. Here we report on neural correlates of this process as rapidly reshaped interactions in primary auditory cortex, measured in three different ways: as changes in response rates, as adaptations of spectrotemporal receptive fields following stimulation by temporally coherent and incoherent tone sequences, and as changes in spiking correlations during the tone sequences. Responses, sensitivity and presumed connectivity were rapidly enhanced by synchronous stimuli, and suppressed by alternating (asynchronous) sounds, but only when the animals engaged in task performance and were attentive to the stimuli. Temporal coherence and attention are therefore both important factors in auditory scene analysis.
Structure of the acetophenone carboxylase core complex: prototype of a new class of ATP-dependent carboxylases/hydrolases
Authors: Weidenweber Sina , Schühle Karola , Demmer Ulrike , Warkentin Eberhard , Ermler Ulrich , Heider Johann 
Published: January 2017

AbstractDegradation of the aromatic ketone acetophenone is initiated by its carboxylation to benzoylacetate catalyzed by acetophenone carboxylase (Apc) in a reaction dependent on the hydrolysis of two ATP to ADP and Pi. Apc is a large protein complex which dissociates during purification into a heterooctameric Apc(αα′βγ)2 core complex of 482 kDa and Apcε of 34 kDa. In this report, we present the X-ray structure of the Apc(αα′βγ)2 core complex from Aromatoleum aromaticum at ca. 3 Å resolution which reveals a unique modular architecture and serves as model of a new enzyme family. Apcβ contains a novel domain fold composed of two β-sheets in a barrel-like arrangement running into a bundle of eight short polyproline (type II)-like helical segments. Apcα and Apcα′ possess ATP binding modules of the ASKHA superfamily integrated into their multidomain structures and presumably operate as ATP-dependent kinases for acetophenone and bicarbonate, respectively. Mechanistic aspects of the novel carboxylation reaction requiring massive structural rearrangements are discussed and criteria for specifically annotating the family members Apc, acetone carboxylase and hydantoinase are defined.
Large-scale, thick, self-assembled, nacre-mimetic brick-walls as fire barrier coatings on textiles
Authors: Das Paramita , Thomas Helga , Moeller Martin , Walther Andreas 
Published: January 2017

AbstractHighly loaded polymer/clay nanocomposites with layered structures are emerging as robust fire retardant surface coatings. However, time-intensive sequential deposition processes, e.g. layer-by-layer strategies, hinders obtaining large coating thicknesses and complicates an implementation into existing technologies. Here, we demonstrate a single-step, water-borne approach to prepare thick, self-assembling, hybrid fire barrier coatings of sodium carboxymethyl cellulose (CMC)/montmorillonite (MTM) with well-defined, bioinspired brick-wall nanostructure, and showcase their application on textile. The coating thickness on the textile is tailored using different concentrations of CMC/MTM (1–5 wt%) in the coating bath. While lower concentrations impart conformal coatings of fibers, thicker continuous coatings are obtained on the textile surface from highest concentration. Comprehensive fire barrier and fire retardancy tests elucidate the increasing fire barrier and retardancy properties with increasing coating thickness. The materials are free of halogen and heavy metal atoms, and are sourced from sustainable and partly even renewable building blocks. We further introduce an amphiphobic surface modification on the coating to impart oil and water repellency, as well as self-cleaning features. Hence, our study presents a generic, environmentally friendly, scalable, and one-pot coating approach that can be introduced into existing technologies to prepare bioinspired, thick, fire barrier nanocomposite coatings on diverse surfaces.
Honokiol as a specific collagen receptor glycoprotein VI antagonist on human platelets: Functional ex vivo and in vivo studies
Authors: Lee Tzu-Yin , Chang Chao-Chien , Lu Wan-Jung , Yen Ting-Lin , Lin Kuan-Hung , Geraldine Pitchairaj , Li Jiun-Yi , Sheu Joen-Rong 
Published: January 2017

AbstractHonokiol, derived from Magnolia officinalis, has various pharmacological properties. Platelet activation plays a critical role in cardiovascular diseases. Honokiol has been reported to inhibit collagen-stimulated rabbit platelet aggregation. However, detailed further studies on the characteristics and functional activity of honokiol in platelet activation are relatively lacking. In the present study, honokiol specifically inhibited platelet aggregation and Ca+2 ion mobilization stimulated with collagen or convulxin, an agonist of glycoprotein (GP) VI, but not with aggretin, an agonist of integrin α2β1. Honokiol also attenuated the phosphorylation of Lyn, PLCγ2, PKC, MAPKs, and Akt after convulxin stimulation. Honokiol have no cytotoxicity in zebrafish embryos. Honokiol diminished the binding of anti-GP VI (FITC-JAQ1) mAb to human platelets, and it also reduced the coimmunoprecipitation of GP VI-bound Lyn after convulxin stimulation. The surface plasmon resonance results revealed that honokiol binds directly to GP VI, with a KD of 289 μM. Platelet function analysis revealed that honokiol substantially prolonged the closure time in human whole blood and increased the occlusion time of thrombotic platelet plug formation in mice. In conclusion, honokiol acts as a potent antagonist of collagen GP VI in human platelets, and it has therapeutic potential in the prevention of the pathological thrombosis.
Goal attribution to inanimate moving objects by Japanese macaques (Macaca fuscata)
Authors: Atsumi Takeshi , Koda Hiroki , Masataka Nobuo 
Published: January 2017

AbstractHumans interpret others’ goals based on motion information, and this capacity contributes to our mental reasoning. The present study sought to determine whether Japanese macaques (Macaca fuscata) perceive goal-directedness in chasing events depicted by two geometric particles. In Experiment 1, two monkeys and adult humans were trained to discriminate between Chasing and Random sequences. We then introduced probe stimuli with various levels of correlation between the particle trajectories to examine whether participants performed the task using higher correlation. Participants chose stimuli with the highest correlations by chance, suggesting that correlations were not the discriminative cue. Experiment 2 examined whether participants focused on particle proximity. Participants differentiated between Chasing and Control sequences; the distance between two particles was identical in both. Results indicated that, like humans, the Japanese macaques did not use physical cues alone to perform the discrimination task and integrated the cues spontaneously. This suggests that goal attribution resulting from motion information is a widespread cognitive phenotype in primate species.
Soft porous silicone rubbers with ultra-low sound speeds in acoustic metamaterials
Authors: Ba Abdoulaye , Kovalenko Artem , Aristégui Christophe , Mondain-Monval Olivier , Brunet Thomas 
Published: January 2017

AbstractSoft porous silicone rubbers are demonstrated to exhibit extremely low sound speeds of tens of m/s for these dense materials, even for low porosities of the order of a few percent. Our ultrasonic experiments show a sudden drop of the longitudinal sound speed with the porosity, while the transverse sound speed remains constant. For such porous elastomeric materials, we propose simple analytical expressions for these two sound speeds, derived in the framework of Kuster and Toksöz, revealing an excellent agreement between the theoretical predictions and the experimental results for both longitudinal and shear waves. Acoustic attenuation measurements also complete the characterization of these soft porous materials.
Ameloblastin induces tumor suppressive phenotype and enhances chemosensitivity to doxorubicin via Src-Stat3 inactivation in osteosarcoma
Authors: Ando Toshinori , Kudo Yasusei , Iizuka Shinji , Tsunematsu Takaaki , Umehara Hanako , Shrestha Madhu , Matsuo Toshihiro , Kubo Tadahiko , Shimose Shouji , Arihiro Koji , Ogawa Ikuko , Ochi Mitsuo , Takata Takashi 
Published: January 2017

AbstractAmeloblastin (AMBN), the most abundant non-amelogenin enamel matrix protein, plays a role in ameloblast differentiation. Previously, we found that AMBN promoted osteogenic differentiation via the interaction between CD63 and integrin β1, leading to the inactivation of Src; however, how AMBN affects the malignant behavior of osteosarcoma is still unclear. Osteosarcoma affects the bone and is associated with poor prognosis because of the high rate of pulmonary metastases and drug resistance. Here we demonstrated that stable overexpression of AMBN induced apoptosis and suppressed colony formation and cell migration via the inactivation of Src-Stat3 pathway in human osteosarcoma cells. Moreover, AMBN induced chemosensitivity to doxorubicin. Thus, AMBN induced a tumor suppressive phenotype and chemosensitivity to doxorubicin via the AMBN-Src-Stat3 axis in osteosarcoma. Indeed, immunohistochemical expression of AMBN was significantly correlated with better outcome of osteosarcoma patients. Our findings suggest that AMBN can be a new prognostic marker and therapeutic target for osteosarcoma combined with conventional doxorubicin treatment.
Structural characterization of nonactive site, TrkA-selective kinase inhibitors
Authors: Su Hua-Poo , Rickert Keith , Burlein Christine , Narayan Kartik , Bukhtiyarova Marina , Hurzy Danielle M. , Stump Craig A. , Zhang Xufang , Reid John , Krasowska-Zoladek Alicja , Tummala Srivanya , Shipman Jennifer M. , Kornienko Maria , Lemaire Peter A. , Krosky Daniel , Heller Amanda , Achab Abdelghani , Chamberlin Chad , Saradjian Peter , Sauvagnat Berengere , Yang Xianshu , Ziebell Michael R. , Nickbarg Elliott , Sanders John M. , Bilodeau Mark T. , Carroll Steven S. , Lumb Kevin J. , Soisson Stephen M. , Henze Darrell A. , Cooke Andrew J. 
Published: December 2016

Significance
Signal transduction through Tropomyosin-related kinase A (TrkA), a receptor tyrosine kinase, is a target for inhibition of chronic pain and could lead to a new class of drugs against pain. Selectivity against kinases can be difficult to achieve, especially against members of the same kinase family. Structures of the compounds bound to TrkA show a binding site comprised of the kinase, which is conserved among the Trk family, and the juxtamembrane (JM), which is not well conserved. Depending on their chemical substructure, the region of the juxtamembrane that interacts with the compounds can be different, leading to differences in specificity. This study emphasizes the importance of including residues beyond the catalytic domain for small-molecule screening, importance of screening by affinity, and structural characterization to understand binding interactions.
Problems of English Composition in Jordanian Secondary Schools
Authors: Al-Makhzoumy Khalaf , Al-Shorafat Mohammed O. 
Published: December 2016

There is a general consensus among researchers that most students of English as a foreign language (EFL) are weak in writing composition. One of the main reasons for their weakness is due to the fact that there is no general agreement among teachers on how to teach and/ or evaluate compositions.Secondary school teachers in Jordan often complain that most students face problems and make errors when they write English compositions. These errors are usually reflected in school exams as well as in the General Secondary School Examination (Tawjihi), held annually by the Ministry of Education.The main concern of this research is to study students' problems in writing English compositions in Jordanian Secondary Schools. A questionnaire has been set for this purpose. The research is expected to identify the most serious problems that secondary students face and recommend certain procedures to avoid these problems and improve students' writing ability in English compo-sitions.
Lateral Preference and L2 Proficiency
Authors: Alptekin Cem , Çetin Elif 
Published: December 2016

Abstract
This study investigates the relationship between the L2 proficiency of advanced EFL learners and biological lateral preference. The former is thought of as the person's advanced ability in English, developed within a school setting and involving both reading comprehension and grammatical and lexical knowledge - as represented by the Michigan Test of English Language Proficiency. The latter is conceptualized as a continuous and multifactorial construct that predicts the degree of the hemispheric specialization of cognitive functions in the human brain as well as the degree of hemisphericity as a personal trait. It is measured by the Lateral Preference Schedule, developed as an instrument to meet the research and clinical needs for a standardized measure of lateral preference. Sixty university students majoring in TEFL participated in the study. Overall, the findings suggest that, from the various lateral preference patterns, only those which involve footed-ness and handedness are related to L2 proficiency. The findings further suggest that the relationship between lateral preference and L2 proficiency is independent of differences in gender.
English and the other Tongues in Official Communicative Interaction in Nigeria
Authors: Omoniyi Tope 
Published: December 2016

Abstract
This paper examines issues of language choice and language use patterns, attitudes to English and to indigenous languages in official communicative interaction in Nigeria as they exist in the offices today. The report is projected against the background of the claim that English is 'the language of government, education, commerce, etc.' in Nigeria; a claim that does not present the current roster of functions performed or shared by English and the other languages. It does not correctly portray workers' preferences of language medium in participating in the numerous communicative interactions they get into in the course of their day's work.
This report acclaims the importance of English particularly in a multiplex society such as Nigeria's, but also goes on to role-sharing and competition for certain communicative functions is actually going on between English and the indigenous languages in the offices today. The report therefore represents a state of the art commentary on language use practice and preferences in the offices. It is a signal to the writers of the Nigerian Constitution and drafters of the National Language Policy per se that a reworking is due. And for other English as a Second Language (ESL) nations, the report is a hint that assessment of the actual roles of English in national life is a continuous process rather than a once-and-for-all issue.
The Candidature of Nigerian Pidgin as a National Language
Authors: Adegbija Efurosibina 
Published: December 2016

Abstract
This paper examines arguments for and against the candidature of Nigerian Pidgin as an official language. Potent buttressing arguments include its widespread use at the grassroots level; its apparent cultural neutrality; and the ease in acquiring it. Arguments against its candidature include its stigmatization; its lack of a cultural base; queries over its bona fide indigenous status; its being a threat to the mastery and use of "standard" English, especially in the educational domain, and its low language development status. The fact that attitudes towards Nigerian Pidgin are completely negative is pinpointed as the most powerful argument against its candidacy as national language. The paper concludes with the observation that on purely linguistic sgrounds, there is no reason why Nigerian Pidgin cannot function as a national language. However, on social grounds, it may, at the moment, not be able to effectively fulfil this role. A language that has no esteem within its major constituency is most unlikely to be awarded such esteem simply because it has been pronounced a national language. It is therefore suggested that serious corpus and status planning efforts are prerequisites for the acceptance of Nigerian Pidgin as a national language and the changing of attitudes towards it; these tasks, it is pointed out, are gargantuan and bedevilling hurdles.
Leur enseigner leur langue?
Authors: Jucquois Guy 
Published: December 2016

Résumé
Qu’enseigne-t-on lorsqu’on enseigne la langue maternelle? Si le contenu civilisationnel paraît de première importance lorsqu’il s’agit de langues étrangères, il semble au contraire absent dans le cas de la langue maternelle. Les instructions officielles ne vont, sur ce point, guère dans le détail.
The Language Learner's Environment as a Resource for Linguistic Input? A Review of Theory and Research
Authors: Pica Teresa 
Published: December 2016

Abstract
This article reviews theory and research on the second language learning environment as a source of input to learners and the contributions made by speakers in learners' environment to their input needs and requirements. Discussion centers on connections between the formal and interactional properties of input which have been identified in research on learners and learning environments and theoretical claims about their contributions to second language learning.