bluuebunny/crossref_metadata_2025_split huggingface dataset:
High expression of tumor necrosis factor receptor‐associated factor 2 promotes tumor metastasis and is associated with unfavorable prognosis in gastric cancer
Authors: Zhao Junjie , Li Haojie , Min Lingqiang , Han Xu , Shu Ping , Yang Yupeng , Gan Qiangjun , Wang Xuefei , Wang Hongshan , Ruan Yuanyuan , Qin Jing , Sun Yihong , Qin Xinyu 
Published: May 2017

AbstractBackgroundTumor necrosis factor receptor‐associated factor 2 (TRAF2) is a key effector in the activation of nuclear factor kappa B (NF‐κB). Nevertheless, the role of TRAF2 in gastric tumorigenesis remains little defined.MethodsImmunohistochemistry was used to find the relationship between TRAF2 expression and clinicopathological characteristics of gastric cancer patients, and nomogram was applied to predict the overall survival of patients. Besides, we performed transwell assays to detect the function of TRAF2 in promoting metastasis and explored the correlations between TRAF2, NF‐κB, and interleukin‐8 (IL‐8) in vitro. In addition, we examined the correlation between TRAF2 and tumor microenvironment by immunohistochemistry staining.ResultsIn our study, we found that TRAF2 expression was markedly increased in gastric cancer tissues. High intratumoral TRAF2 staining, which was associated with tumor invasion and metastasis, was also an independent poor prognosticator for gastric cancer patients. In vitro studies revealed that TRAF2 enhanced NF‐κB activation and subsequent IL‐8 expression in gastric cancer cells. Inhibition of NF‐κB or IL‐8 signaling attenuated TRAF2‐induced migration and invasion abilities. High TRAF2 expression was confirmed to be associated with both high intratumoral and serum levels of IL‐8. In addition, TRAF2 expression was positively correlated with neutrophil and macrophage infiltration as well as microvessels formation in gastric cancer samples.ConclusionsThese results suggest that TRAF2 functions as an important modulator in tumor metastasis and tumor microenvironment formation and is a novel independent prognostic factor of gastric cancer.
Photodynamic treatment outcomes of potentially‐malignant lesions and malignancies of the head and neck region: A systematic review
Authors: Gondivkar Shailesh M. , Gadbail Amol Ramchandra , Choudhary Manjari G. , Vedpathak Priyanka R. , Likhitkar Manoj S. 
Published: May 2017

AbstractAimThe aim of the present study was to systematically review the efficacy of photodynamic therapy (PDT) in the management of oral potentially‐malignant disorders (PMDS) and head and neck squamous cell carcinoma (HNSCC).MethodsFrom 1985 to 2015, PubMed/Medline, Google Scholar, EMBASE, and ISI Web of Knowledge were searched using different combinations of the following key words: PDT, oral precancer, leukoplakia, erythroplakia, erythroleukoplakia, verrucous hyperplasia, oral submucous fibrosis, and HNSCC. Review articles, experimental studies, case reports, commentaries, letters to the editor, unpublished articles, and articles published in languages other than English were excluded.ResultsTwenty‐six studies were included in the present study. The number of patients ranged from 2 to 147, with a mean age of 50‐67 years. The reported numbers of PMDS and HNSCC ranged between 5 and 225. Photosensitizers used were aminolevulinic acid, meta‐tetrahydroxyphenylchlorin, Foscan, hematoporphyrin derivatives, Photofrin, Photosan, and chlorine‐e6. Laser wavelength, power density, irradiation duration were 585‐652 nm, 50‐500 mW/cm2, and 1‐143 minutes, respectively. Complete, partial, and no response to PDT was found in 22.58%‐100%, 4%‐66%, and 0%‐38.70% of PMDS, respectively, and 16%‐100% of complete response in HNSCC patients.ConclusionPDT is effective in the management of PMDS and HNSCC.
Drug‐induced cutaneous lupus erythematosus after immunoglobulin treatment in chronic inflammatory demyelinating polyneuropathy: a case series
Authors: Adrichem Max E. , Starink Markus V. , van Leeuwen Ester M. M. , Kramer Christine , van Schaik Ivo N. , Eftimov Filip 
Published: May 2017

AbstractWe describe six patients with cutaneous lupus erythematosus (cLE) during immunoglobulin G (IgG) treatment. Five patients were diagnosed with chronic inflammatory demyelinating polyneuropathy (CIDP) and one patient with possible CIDP. Five patients received intravenous immunoglobulin (IVIg) and one patient received subcutaneous immunoglobulin (SCIg). Skin lesions were systematically assessed by a dermatologist including skin biopsies. Patients showed disseminated erythematous plaques on several parts of the body with pre‐dominance of the chest and face. Skin biopsies showed perivascular and perifollicular vacuolar inflammation, consistent with the diagnosis of cLE. There were no signs of systemic lupus erythematosus. Anti‐SSA (Ro60) antibodies were found in two patients and anti‐Ro52 antibodies were detectable in one patient. Symptoms improved in three patients after switching to another brand of IVIg and after use of topical corticosteroids. However, these measures did not lead to a complete resolution of the skin lesions. To achieve complete remission, IgG treatment was ceased in four patients. This led to remission of the skin lesions in two patients and to marked improvement in the other two patients. IVIg had to be restarted in two patients because of a relapse of CIDP which led to worsening of the skin lesions. In one patient with clear IVIg dependency, treatment was continued with addition of topical steroids. In the patient using SCIg, cLE was photosensitive and showed spontaneous remission. The relation of cLE with IgG treatment suggests an immunoglobulin‐induced cLE. Only one report previously described the occurrence of IVIg induced cLE in a patient with common variable immunodeficiency.
Going the Distance: Individualism and Interdependence in the Commuter Marriage
Authors: Lindemann Danielle J. 
Published: May 2017

AbstractCommuter spouses—dual‐income couples who live apart for their professional careers—have been the subject of relatively little scholarly research. Another, largely theoretical body of scholarship has explored the fundamental cultural tension generated by the simultaneous embracing of personal autonomy and the institution of marriage in the United States, although few scholars have explicitly sought to understand how these seemingly conflicting cultural goals play out “on the ground.” Drawing on data from in‐depth interviews (N = 97), the analysis finds that commuter couples indeed engaged in two discourses about their marriages that operated in tension. Although they positioned themselves as highly individualistic, interdependence was a key theme in their responses as well. Surprisingly, a substantial minority of respondents indicated that their noncohabitation enhanced their interdependence. These results not only shed light on this understudied population but also broaden our understanding of the evolving cultural meaning of marriage.
Consequences of Partner Incarceration for Women's Employment
Authors: Bruns Angela 
Published: May 2017

AbstractResearch has documented the limited opportunities men have to earn income while in prison and the barriers to securing employment and decent wages upon release. However, little research has considered the relationship between men's incarceration and the employment of the women in their lives. Economic theory suggests that family members of incarcerated individuals may attempt to smooth income fluctuation resulting from incarceration by increasing their labor supply. This study used data from the Fragile Families and Child Wellbeing Study (N = 3,780) to investigate how men's incarceration is associated with the number of hours their female partners work as well as variation in this association. Results showed that, on average, women's hours of work were not significantly impacted by the incarceration of their partners. However, there was a positive relationship between partner incarceration and employment among more advantaged groups of women (e.g., married women, White women).
Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling
Authors: Zhang Mingming , Lin Jie , Wang Shanjie , Cheng Zheng , Hu Jianqiang , Wang Tingting , Man Wanrong , Yin Tao , Guo Wenyi , Gao Erhe , Reiter Russel J. , Wang Haichang , Sun Dongdong 
Published: May 2017

AbstractThis study investigated the effects of melatonin on diabetic cardiomyopathy (DCM) and determined the underlying mechanisms. Echocardiography indicated that melatonin notably mitigated the adverse left ventricle remodeling and alleviated cardiac dysfunction in DCM. The mechanisms were attributed to increased autophagy, reduced apoptosis, and alleviated mitochondrial dysfunction. Furthermore, melatonin inhibited Mst1 phosphorylation and promoted Sirt3 expression in DCM. These results indicated that melatonin may exert its effects through Mst1/Sirt3 signaling. To verify this hypothesis, a DCM model using Mst1 transgenic (Mst1 Tg) and Mst1 knockout (Mst1−/−) mice was constructed. As expected, melatonin increased autophagy, reduced apoptosis and improved mitochondrial biogenesis in Mst1 Tg mice subjected to DCM injury, while it had no effects on Mst1−/− mice. In addition, cultured neonatal mouse cardiomyocytes were subjected to simulated diabetes to probe the mechanisms involved. Melatonin administration promoted autophagic flux as demonstrated by elevated LC3‐II and lowered p62 expression in the presence of bafilomycin A1. The results suggest that melatonin alleviates cardiac remodeling and dysfunction in DCM by upregulating autophagy, limiting apoptosis, and modulating mitochondrial integrity and biogenesis. The mechanisms are associated with Mst1/Sirt3 signaling.
Real‐world effectiveness of ombitasvir/paritaprevir/ritonavir±dasabuvir±ribavirin in patients with hepatitis C virus genotype 1 or 4 infection: A meta‐analysis
Authors: Wedemeyer H. , Craxí A. , Zuckerman E. , Dieterich D. , Flisiak R. , Roberts S. K. , Pangerl A. , Zhang Z. , Martinez M. , Bao Y. , Calleja J.‐L. 
Published: May 2017

SummaryThe direct‐acting antiviral regimen of ombitasvir (OBV)/paritaprevir (PTV)/ritonavir (r)±dasabuvir (DSV)±ribavirin (RBV) demonstrated high rates of sustained viral response at post‐treatment week 12 (SVR12) in clinical trials for treatment of hepatitis C virus (HCV) genotypes (GT) 1 and 4. To confirm the effectiveness of this regimen in the real world, we conducted meta‐analyses of published literature on 30 April 2016. Freeman‐Tukey transformation determined the SVR rate within GTs 1a, 1b and 4, as well as specific SVR rates by cirrhosis or prior treatment experience status. Rates of virologic relapse, hepatic decompensation, drug discontinuation and serious adverse events were also analysed. In total, 20 cohorts across 12 countries were identified, totalling 5158 patients. The overall SVR12 rates were 96.8% (95% CI 95.8‐97.7) for GT1 and 98.9% (95% CI 94.2‐100) for GT4. For GT1a patients, the SVR rates were 94% and 97% for those with or without cirrhosis, and 94% overall. For GT1b patients, the SVR rates were 98% and 99% for those with or without cirrhosis, and 98% overall. The virologic relapse rate of GT1 patients was 1.3%, across 3524 patients in nine studies that reported this parameter. The rate of hepatic decompensation was less than 1% across five studies, including 3440 patients, 70% of which had cirrhosis. Conclusions: Real‐world SVR12 rates for OBV/PTV/r±DSV±RBV were consistently high across HCV GT1 and four irrespective of cirrhosis status or prior HCV treatment experience, confirming effectiveness within a diverse patient population across multiple cohorts and countries.
Do Business Cycles Have Long‐Term Impact for Particular Cohorts?
Authors: Andersen Torben M. , Maibom Jonas , Svarer Michael , Sørensen Allan 
Published: May 2017

AbstractDo business cycle fluctuations and changes in employment produce cohorts with permanently different labour market attachment? Taking an explicit cohort perspective and based on Danish register data, we find noticeable age dependent persistence in employment rates at the cohort level. Younger workers tend to be more exposed to business cycle fluctuations than older workers, but importantly they recover more quickly than older workers for whom persistence is stronger. Moreover, following the employment trajectories of cohorts, no cohorts have been permanently ‘scarred’ in terms of employment due to a sequence of adverse shocks. Finally, an explicit account of overlapping cohorts is shown to affect assessments of persistence in aggregate employment rates.
Hepatitis B in Egypt: A cross‐sectional analysis of prevalence and risk factors for active infection from a nationwide survey
Authors: Ismail Sharif A. , Cuadros Diego F. , Benova Lenka 
Published: May 2017

AbstractBackground & AimsViral hepatitis is a major public health challenge in Egypt but little is known about the epidemiology of the hepatitis B virus (HBV) infection, its geographical distribution, or risk factors for infection in the Egyptian context. This study addresses this deficit using data from a nationally representative survey.MethodsCross‐sectional analysis of data gathered from men and women aged 15‐59 in the Egypt Health Issues Survey (EHIS) 2015, including logistic regression to evaluate the contribution of different factors to risk of HBV infection. This was supplemented by spatial analysis of the distribution of acute or chronic HBV infection at governorate level, and the ecological relationship between HBV and HCV infections.ResultsPopulation HBV prevalence was 1.4% (95% confidence interval [CI] 1.2‐1.6), with a HBV‐HCV co‐infection rate of 0.06%. Spatial analysis showed localisation of HBV infected individuals primarily to urban areas of Upper Egypt (in contrast to HCV for which prevalence is highest in rural Lower Egypt), and those in early middle age (Adjusted Odds Ratio [AOR] 3.32, 95% CI: 1.66‐6.63). HBV positive status among other household members emerged as a powerful driver of infection risk in this analysis (AOR=10.75, 95% CI: 4.98‐23.24).ConclusionSpatial distribution of HBV infection in Egypt differs markedly from HCV and co‐infection rates are low. Within‐household transmissions appear to be particularly important in explaining the persistence of HBV infection in the general population. Prevention strategies should focus on urban Upper Egypt, and particularly those households with documented cases of infection.
New insights on petrography and geochemistry of impactites from the Lonar crater, India
Authors: Ray Dwijesh , Upadhyay Dewashish , Misra Saumitra , Newsom Horton E. , Ghosh Sambhunath 
Published: May 2017

AbstractThe Lonar impact crater, India, is one of the few known terrestrial impact craters excavated in continental basaltic target rocks (Deccan Traps, ~65 Ma). The impactites reported from the crater to date mainly include centimeter‐ to decimeter‐sized impact‐melt bombs, and aerodynamically shaped millimeter‐ and submillimeter‐sized impact spherules. They occur in situ within the ejecta around the crater rim and show schlieren structure. In contrast, non–in situ glassy objects, loosely strewn around the crater lake and in the ejecta around the crater rim do not show any schlieren structure. These non–in situ fragments appear to be similar to ancient bricks from the Daityasudan temple in the Lonar village. Synthesis of existing and new major and trace element data on the Lonar impact spherules show that (1) the target Lonar basalts incorporated into the spherules had undergone minimal preimpact alteration. Also, the paleosol layer as preserved between the top‐most target basalt flow and the ejecta blanket, even after the impact, was not a source component for the Lonar impactites, (2) the Archean basement below the Deccan traps were unlikely to have contributed material to the impactite parental melts, and (3) the impactor asteroid components (Cr, Co, Ni) were concentrated only within the submillimeter‐sized spherules. Two component mixing calculations using major oxides and Cr, Co, and Ni suggest that the Lonar impactor was a EH‐type chondrite with the submillimeter‐sized spherules containing ~6 wt% impactor components.
Roles of NADPH oxidase and mitochondria in flow‐induced vasodilation of human adipose arterioles: ROS‐induced ROS release in coronary artery disease
Authors: Zinkevich Natalya S. , Fancher Ibra S. , Gutterman David D. , Phillips Shane A. 
Published: May 2017

AbstractObjectivesH2O2 contributes to FID of human arterioles. This study is designed to examine the roles of mitochondria and NADPH oxidase in modulating the release of ROS and in mediating FID. We tested whether NADPH oxidase contributes to mitochondrial ROS generation in arterioles during CAD.MethodsVisceral adipose arterioles obtained from patients with or without CAD were cannulated and pressurized for videomicroscopic measurement of arteriolar diameters. Dilator responses and ROS production during flow were determined in the presence and absence of the NADPH oxidase inhibitor gp91ds‐tat and the mitochondrial electron transport inhibitor rotenone.ResultsBoth dilation and H2O2 generation during flow were reduced in the presence of rotenone (13.5±8% vs 97±% without rotenone) or gp91ds‐tat in patients with CAD, while patients without CAD exhibited H2O2‐independent dilations. Mitochondrial superoxide production during flow was attenuated by gp91ds‐tat in arterioles from CAD patients.ConclusionsThese findings indicate that ROS produced by NADPH oxidase are an upstream component of the mitochondria‐dependent pathway contributing to flow‐dependent H2O2 generation and dilation in peripheral microvessels from patients with CAD. We conclude that in CAD, both mitochondria and NADPH oxidase contribute to FID through a redox mechanism in visceral arterioles.
Production of Trichophyton rubrum microspores in large quantities and its application to evaluate amorolfine/azole compound interactions in vitro
Authors: Laurent Alexis , Monod Michel 
Published: May 2017

SummaryTrichophyton rubrum is the most frequently isolated dermatophyte species in European countries. The lack or poor sporulation of T. rubrum has always been a major complication and a limiting factor when performing antifungal susceptibility testing. Therefore, we describe an in vitro method aiming to enhance sporulation of various T. rubrum isolates in order to perform antifungigrams. A combination of high CO2 tensions and incubation on PDA growth medium revealed to be optimal for sporulation of all tested T. rubrum isolates. This method was further used to examine in vitro the combined effects of amorolfine and azole derivatives against fungal growth using adapted checkerboard microdilution assays and an isobolographic approach of the data, adapted disc diffusion and Etest assays. Non‐antagonistic and synergistic effects were observed in these settings with amorolfine combined to each of the tested azole compounds. The optimised culture method appeared to be suitable for T. rubrum isolates for which antifungigrams were especially difficult to obtain because of the lack of sporulation.
Drivers of tree fecundity in pedunculate oak (Quercus robur) refugial populations at the species’ southwestern range margin
Authors: Moracho E. , Jordano P. , Hampe A. 
Published: May 2017

Abstract

The current low latitudinal range margins of many extra‐tropical plant species consist of small and scattered populations that persist locally in microrefugia. It remains poorly understood how their refugial distribution affects mating patterns and reproductive success. Here we examine flower and acorn production and their determinants in refugial populations of the widespread European forest tree pedunculate oak (Quercus robur).

We monitored male flower, female flower and acorn production in 159 adult trees from 12 oak stands over 2 years. We related these and derived parameters to a series of ecological and genetic predictor variables extrinsic (stand size, density and isolation as well as elevation, topography and forest cover) or intrinsic (size, phenology and several genotypic measures) to the target tree.

Tree fertility was unrelated to extrinsic factors but determined by tree size, although we detected size‐independent variation in reproductive investment. Female flower number accurately predicted acorn crop size. Fruit set differed between years, evidencing the existence of pollen limitation at the landscape but not at the local scale. Fruit set also tended to increase with the number of mates of the target tree. We detected no other evidence for genetic constraints on mating.

Reproduction was triggered by a combination of small‐scale and landscape‐scale drivers. Although short‐distance mating prevailed, limited pollen flow did not appear to significantly constrain reproductive success. The high intrinsic ability of populations to maintain their reproductive capacity may help explain their successful long‐term persistence in an adverse broader environment.
Brain activities associated with learning of the Monty Hall Dilemma task
Authors: Hirao Takahiro , Murphy Timothy I. , Masaki Hiroaki 
Published: May 2017

AbstractThe Monty Hall Dilemma (MHD) poses a counterintuitive probabilistic problem to the players of this game. In the MHD task, a participant chooses one of three options where only one contains a reward. After one of the unchosen options (always no reward) is disclosed, the participant is asked to make a final decision: either change to the remaining option or stick with their first choice. Although the probability of winning if they change is higher (2/3) compared to sticking with their first choice (1/3), most people stick with their original selection and often lose. In accordance with previous research, repetitive exposure to the MHD task increases the change behavior without any obvious understanding of the mathematical reasons why changing increases their chance of being rewarded. We recorded the stimulus‐preceding negativity (SPN), an ERP that might reflect the informative value of the feedback. In the second half of the task, feedback was predicted to be less informative because learning had taken place. Indeed, the SPN amplitude became smaller over the frontal region. Also, the SPN amplitude was larger for change than for stick trials. These results suggest that learning in the MHD might be manifest in affective‐motivational anticipation as indicated by the SPN.
Temporal dynamics of object location processing in allocentric reference frame
Authors: Török Ágoston , Kóbor Andrea , Persa György , Galambos Péter , Baranyi Péter , Csépe Valéria , Honbolygó Ferenc 
Published: May 2017

AbstractThe spatial location of objects is processed in egocentric and allocentric reference frames, the early temporal dynamics of which have remained relatively unexplored. Previous experiments focused on ERP components related only to egocentric navigation. Thus, we designed a virtual reality experiment to see whether allocentric reference frame‐related ERP modulations can also be registered. Participants collected reward objects at the end of the west and east alleys of a cross maze, and their ERPs to the feedback objects were measured. Participants made turn choices from either the south or the north alley randomly in each trial. In this way, we were able to discern place and response coding of object location. Behavioral results indicated a strong preference for using the allocentric reference frame and a preference for choosing the rewarded place in the next trial, suggesting that participants developed probabilistic expectations between places and rewards. We also found that the amplitude of the P1 was sensitive to the allocentric place of the reward object, independent of its value. We did not find evidence for egocentric response learning. These results show that early ERPs are sensitive to the location of objects during navigation in an allocentric reference frame.