bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of smoking status on immunotherapy for lung cancer: a systematic review and meta-analysis
Authors: Luo Dachen , Yang Dongmei , Cao Dan , Gong Zonglian , He Fang , Hou Yaqin , Lin Shan 
Published: October 2024

BackgroundRecent studies have yielded conflicting results regarding the relationship between smoking history and the effectiveness of immune checkpoint inhibitors (ICIs) for advanced lung cancer. While some studies have suggested that smoking may enhance the response to immunotherapy in patients with lung cancer, other findings indicate the contrary. Therefore, we conducted a systematic review and meta-analysis to thoroughly examine this association.MethodsWe searched the PubMed, Embase, and Scopus databases for clinical trials comparing immunotherapy with conventional chemotherapy as the primary treatment for advanced lung cancer. A random effects model was used to synthesize hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS). We also conducted predefined subgroup analyses to investigate the efficacy disparities between never-smokers and smokers who were administered immunotherapy alone or in combination with chemotherapy, as well as the differences between former and current smokers under similar treatment modalities.ResultsOur analysis included data from 17 Phase III clinical trials involving 10,283 patients. The findings indicate that immunotherapy benefits both smokers and never-smokers with lung cancer or non-small cell lung cancer, yielding pooled HRs for OS of 0.74 (95% CI: 0.59–0.92) and 0.73 (95% CI: 0.67–0.80), respectively. A significant interaction effect was not observed (HR: 0.98, 95% CI: 0.77–1.24, pinteraction = 0.14), and the tumor type, immunotherapy combination, and type of immunotherapy did not differ among the groups in the subgroup analyses. Similarly, both former and current smokers experienced a significant survival benefit from immunotherapy, with pooled HRs for OS of 0.79 (95% CI: 0.68–0.91) and 0.71 (95% CI: 0.59–0.87), respectively. However, a significant interaction effect was also not observed (HR: 0.91, 95% CI: 0.74–1.11, pinteraction = 0.14).ConclusionOur findings suggest that smoking status does not affect the effectiveness of immunotherapy for lung cancer treatment. However, additional high-quality clinical trials are needed to confirm this conclusion.Systematic review registrationhttps://inplasy.com/register/, identifier INPLASY2023110058.
Automated mental health screening in pediatric lupus: associations with disease features and treatment
Authors: Harper Lauren , Ardoin Stacy P. , Leever Alana , Driest Kyla , Sivaraman Vidya , Taxter Alysha J. 
Published: October 2024

IntroductionPatients with childhood-onset systemic lupus erythematosus (c-SLE) have higher rates of depression than their peers, which has been associated with worse medical outcomes. Therefore, it is imperative that their mental health be addressed. We utilized quality improvement (QI) methodology to automate mental health screening for patients with lupus within a pediatric rheumatology clinic. The retrospective cohort study aims to evaluate the association between mental health screening outcomes and demographics, medications, and disease activity measures in patients with childhood lupus.MethodsThe mental health QI team at a quaternary pediatric rheumatology center implemented an automated process for mental health screening in patients with c-SLE. Patients seen between 2017 and June 2023 with a diagnosis of c-SLE were identified using International Classification of Disease -Clinical Modification (ICD-CM) codes. Disease activity was assessed with the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI 2K). Medications were identified on outpatient and inpatient orders for conventional synthetic and biologic disease-modifying anti-rheumatic drugs, hydroxychloroquine, corticosteroids, and aspirin. Mental health screening was accomplished with the Patient Health Questionnaire (PHQ). Descriptive statistics, univariate and multivariate linear regression were used.ResultsBetween January 2017 and June 2023, 117 patients with c-SLE (41% with lupus nephritis) completed 534 total screenings. Each patient completed PHQ screenings, a median of 5 [interquartile range 2, 6] times. Screening increased when the screening process was automated. Those who were Black, female, or prescribed leflunomide, mycophenolate, and corticosteroids had higher PHQ scores.ConclusionsMental health support is essential for patients with chronic rheumatologic diseases such as SLE. Sustainable processes for quickly identifying depression are needed for optimal care of patients with SLE. Our process of automated, streamlined mental health screening successfully increased the screening of patients with SLE at every visit and led to timely interventions for positive PHQ scores. Higher PHQ scores were correlated with patients on leflunomide, mycophenolate, and corticosteroids. Future research should identify modifiable risk factors for high PHQ scores that the medical team can target.
Multiple cell-death patterns predict the prognosis and drug sensitivity of melanoma patients
Authors: Chen Zewei , Zhang Ruopeng , Zhao Zhoukai , Zhao Baiwei , Zhang Feiyang , Chen Guoming , Chen Xiaojiang , Wei Chengzhi , Lin Jun , Lin Feizhi , Zheng Ziqi , Jiang Kaiming , Nie Runcong , Chen Yingbo 
Published: October 2024

BackgroundMelanoma, a malignant tumor of the skin, presents challenges in its treatment process involving modalities such as surgery, chemotherapy, and targeted therapy. However, there is a need for an ideal model to assess prognosis and drug sensitivity. Programmed cell death (PCD) modes play a crucial role in tumor progression and has the potential to serve as prognostic and drug sensitivity indicators for melanoma.MethodsWe analyzed 13 PCD modes including apoptosis, necroptosis, ferroptosis, pyroptosis, netotic cell death, entotic cell death, lysosome-dependent cell death, parthanatos, autophagy-dependent cell death, oxeiptosis, disulfidptosis, and alkaliptosis. These modes were used to construct a model that incorporated genes related to these 13 PCD modes to establish a cell death index (CDI) to conduct prognosis analysis. Transcriptomic, genomic, and clinical data were collected from cohorts including TCGA-SKCM, GSE19234, and GSE65904 to validate this model.ResultsA CDI consisting of ten gene signatures was established using machine learning algorithms and divided into two groups based on CDI values. The high CDI group exhibited relatively lower numbers of immune-infiltrating cells and showed resistance to commonly used drugs such as docetaxel and axitinib. Our validation results demonstrated good discrimination in PCA analysis between CDI groups, and melanoma patients with higher CDI values had worse postoperative prognoses (all p &lt; 0.01).ConclusionThe CDI model, incorporating multiple PCD modes, accurately predicts the clinical prognosis and drug sensitivity of melanoma patients.
Resveratrol’s bibliometric and visual analysis from 2014 to 2023
Authors: Wei Haoyue , Fang Guowei , Song Weina , Cao Hongye , Dong Ruizhe , Huang Yanqin 
Published: October 2024

IntroductionResveratrol (RSV) is a natural polyphenolic compound derived from a variety of plants that possesses a wide range of biological activities, including antioxidant, anti-inflammatory, antitumor, antibacterial, antiviral, anti-aging, anti-radiation damage, anti-apoptosis, immune modulation, regulation of glucolipid metabolism, inhibition of lipid deposition, and anti-neuro. It is therefore considered a promising drug with the potential to treat a wide range of diseases.MethodIn this study, using Web of Science Core Collection (WoSCC) and CiteSpace bibliometric tool, VOSviewer quantitatively visualized the number of countries, number of authors, number of institutions, number of publications, keywords, and references of 16,934 resveratrol-related papers from 2014–2023 for quantitative and qualitative analysis. ResultsThe results showed that an average of 1693.4 papers were published per year, with a general upward trend. China had the most publications with 5877. China Medical University was the institution with the largest number of publications and the highest number of citations in the field. The research team was mainly led by Prof. Richard Tristan, and the journal with the highest number of published papers was Molecular. Dietary polyphenols, oxidative stress, and antioxidant and anti-inflammatory effects are the most frequently cited articles. Oxidative stress, apoptosis, expression, and other keywords play an important role in connecting other branches of the field.DiscussionOur analysis indicates that the integration of nanoparticles with RSV is poised to become a significant trend. RSV markedly inhibits harmful bacteria, fosters the proliferation of beneficial bacteria, and enhances the diversity of the intestinal flora, thereby preventing intestinal flora dysbiosis. Additionally, RSV exhibits both antibacterial and antiviral properties. It also promotes osteogenesis and serves a neuroprotective function in models of Alzheimer's disease. The potential applications of RSV in medicine and healthcare are vast. A future research challenge lies in modifying its structure to develop RSV derivatives with superior biological activity and bioavailability. In the coming years, innovative pharmaceutical formulations of RSV, including oral, injectable, and topical preparations, may be developed to enhance its bioavailability and therapeutic efficacy.
Effects of shading on morphology, photosynthesis characteristics, and yield of different shade-tolerant peanut varieties at the flowering stage
Authors: Wang Jing , Yao Rui , Sun Zexin , Wang Meiwen , Jiang Chunji , Zhao Xinhua , Liu Xibo , Zhong Chao , Zhang He , Zhao Shuli , Wang Xiaoguang , Yu Haiqiu 
Published: October 2024

IntroductionIn maize and peanut intercropping, shading emerges as a critical factor for restricting peanut growth, yield, and quality.MethodsThis study investigated the impact of 30% shade on shade-tolerant [Huayu 22 (HY22) and Fuhua 12 (FH12)] and shade-sensitive [Nonghua 11 (NH11) and Nonghua 5(NH5)] peanut varieties, with non-shaded condition as the control (CK). The effects of shade stress on plant morphology, photosynthetic characteristics, dry-matter accumulation, chloroplast ultra-microstructure, yield, and quality of different shade-tolerant peanut varieties were examined.ResultsCompared to that in the control, shade stress led to an elongation of the main stem, shortening of the lateral branches, and reduction in the leaf area. However, these changes were less significant in the shade-tolerant than in the shade-sensitive peanut varieties, with minimal effect on the elongation of the main stem height and shortening of the lateral branches. Differences in leaf area became significant during the later stages of shade stress, particularly pronounced in the shade-sensitive peanut varieties. To enhance light capture by leaves, the shade-tolerant peanut varieties exhibited increased chlorophyll content and chloroplast grain-layer numbers. The decrease in the chlorophyll a/b ratio was more pronounced in the shade-tolerant than in the shade-sensitive peanut varieties, with significant differences. However, reduced activities of ribulose 1,5-biphosphate (RuBP) carboxylase/oxygenase and fructose 1,6-biphosphate aldolase (FBA) resulted in decreased net photosynthetic rates, particularly evident in the shade-sensitive peanut varieties during the late shade period. Shade stress led to decreased dry-matter accumulation, reduced weight of 100 fruits and kernels, and a significant decline in yield in the shade-sensitive cultivars. Shading also affected peanut-kernel quality. Compared with that in the control, the protein content increased and amino-acid (except cysteine) content decreased in the shade-tolerant cultivars.DiscussionUnder shade stress, shade tolerant peanut varieties have increased the yield by improving the photosynthetic efficiency, which provided a reference for rational selection of shade tolerant peanut varieties in maize and peanut intercropping system.
Constructing more comprehensive pollination networks: integrating diurnal and nocturnal pollen data with visitation in a subalpine wetland community
Authors: Teng Yue , Vamosi Jana C. , Wang Xiao-Fan , Gong Yan-Bing 
Published: October 2024

IntroductionSampling for describing plant–pollinator interaction networks has been performed using techniques that either focus on the plants (with flower-visit data) or the animals (with analyzing pollen on the body surface of flower visitors). The differences in the structure of the networks obtained using these methods likely influences our understanding of the contribution of nocturnal pollinators, yet this key finding has yet to be the focus of study.MethodsIn this study, we conducted an intensive diurnal field survey in the subalpine meadows of the Dajiuhu Wetland and supplemented the data with an analysis of diurnal and nocturnal pollen data to examine the changes in pollination networks.ResultsWe observed 41 plant and 154 pollinator species, corresponding to 665 specific interactions. Visitation and pollen analyses showed significant differences in the composition and interaction between network plants and pollinators, resulting in important structural changes in the network. Given that the diurnal pollen data showed new links that were preferentially attached to highly connected nodes, the level of asymmetric specialization did not decrease; however, nestedness increased 1.3-fold, and mean pollinator connectivity from 3.1 to 5.1. As the behaviors of nocturnal pollinators tended to be more specialized, the inclusion of nocturnal pollen data led to an increase in the number of extreme-specialist pollinator species. Consequently, nestedness decreased 0.8-fold, but mean plant connectivity went from 14.2 to 16.2.DiscussionThese findings suggest that the structure of pollination networks is influenced by the sampling methods and the level of detail of the investigation. Our study has strong implications for the development of monitoring schemes for plant–pollinator interactions. Due to the practical difficulties of nocturnal field visitation, when conducting research, combining diurnal field visitation with both diurnal and nocturnal pollen analyses is the most convenient and realistic method to capture the full complexity of these networks.
STRYV365 peak team and Brain agents: teacher perspectives on school impact of a trauma-informed, social–emotional learning approach for students facing adverse childhood experiences
Authors: Stoltenburg Abbey , McGuire Madison , Liverman Elizabeth , Lumelsky Paula , Bates Garrett , Gundacker Constance , Currie Brandon , Meurer John R. 
Published: October 2024

IntroductionAdverse childhood experiences (ACEs) have a profound impact on children’s and adolescents’ academic performance and overall wellbeing. In contrast, positive childhood experiences help mitigate the negative effects of ACEs on health and wellbeing. Trauma-informed and social–emotional learning (SEL) programs in schools may address these impacts, with school staff playing a pivotal role in ensuring their success and influencing school outcomes. This study aimed to assess the strengths, weaknesses, and areas for improvement in the STRYV365 peak team and Brain Agents programs. The aim was to refine program implementation and determine the preliminary effects on students, teachers, and the broader school environment.MethodsTo achieve this goal, four focus groups were conducted after the program concluded, involving 17 school leaders, administrators, and teachers from four urban schools serving students in fifth through ninth grades. The audio transcripts were professionally transcribed and analyzed by four co-authors using Dedoose for inductive coding, leading to the identification of major themes and subthemes.ResultsThree key themes were identified from transcripts: school-wide perspectives of STRYV365 programs, strengths and impacts of STRVY365 programs, and suggestions for program improvement. School staff noted that the peak team was particularly engaging for students, helping them develop SEL skills and foster both peer-to-coach and peer-to-peer relationships. Additionally, the STRYV365 programs were found to enhance student–teacher relationships and staff relationships. Teachers expressed strong interest in taking a more active role in future programming.DiscussionOverall, this study highlights the importance of teacher and administrator involvement in maintaining consistent SEL activities for urban youth. The findings also suggest that short-term, 4-week SEL programs can have a positive effect on school culture, as well as on student–teacher relationships and teacher–teacher relationships.
ChatGPT's quality: Reliability and validity of concept inventory items
Authors: Küchemann Stefan , Rau Martina , Schmidt Albrecht , Kuhn Jochen 
Published: October 2024

IntroductionThe recent advances of large language models (LLMs) have opened a wide range of opportunities, but at the same time, they pose numerous challenges and questions that research needs to answer. One of the main challenges are the quality and correctness of the output of LLMs as well as the overreliance of students on the output without critically reflecting on it. This poses the question of the quality of the output of LLMs in educational tasks and what students and teachers need to consider when using LLMs for creating educational items. In this work, we focus on the quality and characteristics of conceptual items developed using ChatGPT without user-generated improvements.MethodsFor this purpose, we optimized prompts and created 30 conceptual items in kinematics, which is a standard topic in high-school level physics. The items were rated by two independent experts. Those 15 items that received the highest rating were included in a conceptual survey. The dimensions were designed to align with the ones in the most commonly used concept inventory, the Force Concept Inventory (FCI). We administered the designed items together with the FCI to 172 first-year university students. The results show that ChatGPT items have a medium difficulty and discriminatory index but they overall exhibit a slightly lower average values as the FCI. Moreover, a confirmatory factor analysis confirmed a three factor model that is closely aligned with a previously suggested expert model.Results and discussionIn this way, after careful prompt engineering, thorough analysis and selection of fully automatically generated items by ChatGPT, we were able to create concept items that had only a slightly lower quality than carefully human-generated concept items. The procedures to create and select such a high-quality set of items that is fully automatically generated require large efforts and point towards cognitive demands of teachers when using LLMs to create items. Moreover, the results demonstrate that human oversight or student interviews are necessary when creating one-dimensional assessments and distractors that are closely aligned with students' difficulties.
Case report: Online eye movement desensitization and reprocessing approach in children: a case series
Authors: Citil Akyol Canan , Kutlu Mustafa , Korkmazlar Ümran 
Published: October 2024

ObjectiveThe aim of this study was to examine the use of Eye Movement Desensitization and Reprocessing (EMDR) in online counseling for children with single-incident trauma.MethodA qualitative case study method was employed. The research was conducted with two volunteering children and their parents. The sessions were transcribed by the authors, and code names (Ipek and Eylül) were assigned to protect the participants’ identities. İpek’s traumatic memory was explored through drawing pictures with tactile bilateral stimuli and Eylül’s traumatic experience was addressed using tactile bilateral stimuli during the EMDR therapeutic story technique. The Child Revised Impact of Events Scale (CRIES-8) was used for pre-test, post-test, and follow-up testing to support the session descriptions.ResultsThe results indicated that post-traumatic symptoms were reduced and remained at a low level for an extended period in both clients.ConclusionsIt is suggested that future studies should explore various bilateral stimulation methods in online EMDR, conduct larger-scale studies with children who have experienced different types of traumatic events, and investigate the impact of various EMDR protocols on children.
Evaluating dysphagia in Alzheimer’s disease: the significance of age and medical comorbidities,a cross-sectional study from a tertiary psychiatric hospital in Guangzhou China
Authors: Ye Junrong , Pan Yuanxin , Zhou Tingwei , Liu Fei , Wei Yanheng , Chen Jiao , Wang Wen , Zheng Xueyu , Liu Dingjie , Wu Shengwei , Li Zezhi , Guo Jianxiong , Xiao Aixiang 
Published: October 2024

ObjectiveTo investigate the influencing factors of dysphagia in Alzheimer’s disease (AD) patients.MethodsThe study evaluated the demographic characteristics, nutritional status, social functioning, and swallowing dysfunction of 109 hospitalized AD patients.ResultsThe sample include 65.1% of female patients, mainly concentrate in &gt;70 years old (72.5%). The illness duration is mainly 0~5 years (62.4%). After adjusting for confounding factors such as gender, poor lifestyle habits, illness duration, marital status, route to admission, concomitant medical illness, nutritional status, and social functioning, we find that the swallowing function in patients with AD is related to route to admission and concomitant medical illness (mainly includes: circulatory disease and respiratory disease). Age ≥90 years old and more concomitant medical illness contribute to a lower swallowing dysfunction score in patients with AD (P&lt;0.05).ConclusionAge and concomitant medical illness are the important influencing factors in swallowing dysfunction in patients with AD. Therefore, we believe that future research should focus on the treatment and care of patients with medical conditions in order to enhance the swallowing function in patients with AD.