bluuebunny/crossref_metadata_2025_split huggingface dataset:
Closed-Form Approximations for Optimal (r, q) and (S, T) Policies in a Parallel Processing Environment
Authors: Ang Marcus , Sigman Karl , Song Jing-Sheng , Zhang Hanqin 
Published: July 2017

We consider a single-item continuous-review (r, q) inventory system with a renewal demand process and independent, identically distributed stochastic lead times. Using a stationary marked-point process technique and a heavy-traffic limit, we prove a previous conjecture that inventory position and inventory on-order are asymptotically independent. We also establish closed-form expressions for the optimal policy parameters and system cost in heavy-traffic limit, the first of their kind, to our knowledge. These expressions sharpen our understanding of the key determinants of the optimal policy and their quantitative and qualitative impacts. For example, the results demonstrate that the well-known square-root relationship between the optimal order quantity and demand rate under a sequential processing environment is replaced by the cube root under a stochastic parallel processing environment. We further extend the study to periodic-review (S, T) systems with constant lead times. The electronic companion is available at https://doi.org/10.1287/opre.2017.1623 .
Spectral laser damage testing of optical materials
Authors: Schröder Sven , Garrick Méabh , Munser Anne-Sophie , Trost Marcus 
Published: July 2017

Abstract
The spectral laser-induced damage of optical components was measured using a new instrument based on combining a laser-induced damage threshold (LIDT) testing procedure with angle-resolved light scattering and using a tunable optical parametric oscillator laser source. Tests on aluminum mirrors revealed a significant drop of the LIDT around 800 nm, which is not predicted by simple scaling laws. For near-infrared edge filters, remarkable changes in the LIDT around the band edge were observed, which are linked to the spectral variation of the field distribution in the interference coating.
Der Einfluss von Fahrermerkmalen auf den erlebten Fahrkomfort im
hochautomatisierten Fahren
Authors: Beggiato Matthias , Hartwich Franziska , Krems Josef 
Published: July 2017

Zusammenfassung
Die Veränderung der
Fahrerrolle im hochautomatisierten Fahren vom Akteur zum „Passagier am Fahrersitz“ wirft neue Fragen auf nach dem erlebten
Fahrkomfort in dieser veränderten Situation. In
einer kombinierten Fahrsimulator- und Realfahrstudie
wurde der Einfluss von Fahrermerkmalen auf den wahrgenommenen
Fahrkomfort, die Akzeptanz und den Fahrspaß im
hochautomatisierten Fahren untersucht.
Failure analysis of eleven Gates Glidden drills that fractured intraorally during post space preparation. A retrieval analysis study
Authors: Al Jabbari Youssef S. , Fournelle Raymond , Al Taweel Sara M. , Zinelis Spiros 
Published: July 2017

Abstract
The purpose of this study was to determine the failure mechanism of clinically failed Gates Glidden (GG) drills. Eleven retrieved GG drills (sizes #1 to #3) which fractured during root canal preparation were collected and the fracture location was recorded based on macroscopic observation. All fracture surfaces were investigated by a SEM. Then the fractured parts were embedded in acrylic resin and after metallographic preparation, the microstructure and elemental composition was evaluated by SEM and EDS. The Vickers hardness (HV) of all specimens was also determined. Macroscopic examination and SEM analysis showed that the drills failed near the hand piece end by torsional fatigue with fatigue cracks initiating at several locations around the circumference and propagating toward the center. Final fracture followed by a tensile overloading at the central region of cross section. Microstructural analysis, hardness measurements and EDS show that the drills are made of a martensitic stainless steel like AISI 440C. Based on the findings of this study, clinicians should expect fatigue fracture of GG drills that have small size during root canal preparation. Selection of a more fatigue resistant stainless steel alloy and enhancing the instrument design might reduce the incidence of quasi-cleavage fracture on GG drills.
Defining the critical role of nurses in diagnostic error prevention: a conceptual framework and a call to action
Authors: Gleason Kelly T. , Davidson Patricia M. , Tanner Elizabeth K. , Baptiste Diana , Rushton Cynda , Day Jennifer , Sawyer Melinda , Baker Deborah , Paine Lori , Himmelfarb Cheryl R. Dennison , Newman-Toker David E. 
Published: July 2017

Abstract
Nurses have always been involved in the diagnostic process, but there remains a pervasive view across physicians, nurses, and allied health professionals that medical diagnosis is solely a physician responsibility. There is an urgent need to adjust this view and for nurses to take part in leading efforts addressing diagnostic errors. The purpose of this article is to define a framework for nursing engagement in the diagnostic process that can serve as a catalyst for nurses to engage in eliminating preventable harms from diagnostic error. We offer a conceptual model to formalize and expand nurses’ engagement in the diagnostic process through education, maximize effectiveness of interprofessional teamwork and communication through culture change, and leverage the nursing mission to empower patients to become active members of the diagnostic team. We describe the primary barriers, including culture, education, operations, and regulations, to nurses participating as full, equal members of the diagnostic team, and illustrate our approach to addressing these barriers. Nurses already play a major role in diagnosis and increasingly take ownership of this role, removing barriers will strengthen nurses’ ability to be equal, integral diagnostic team members. This model should serve as a foundation for increasing the role of the nurse in the diagnostic process, and calling nurses to take action in leading efforts to reduce diagnostic error.
A Generalized ARFIMA Model with Smooth Transition Fractional Integration Parameter
Authors: Boubaker Heni 
Published: July 2017

AbstractThis paper proposes a model of time-varying fractional integration where the long-memory parameter,d$d$, in an ARFIMA model is allowed to depend ont$t$and evolve according to a Smooth Transition Regressive (STR) model advanced by Teräsvirta (1994, 1998) . To estimate the time-varying fractional integration parameter, we suggest a new multi-step estimation method based on the wavelet approach using the instantaneous least squares estimator (ILSE). We conduct some simulation experiments and we find that our estimation iterative procedure performs better than that proposed by Boutahar, Dufrénot, and Péguin-Feissolle (2008). An empirical application of this methodology to the volatility of some financial time series is used for illustration purposes. Finally, it is shown that the model proposed offers an interesting framework to describe long-range dependence in the volatility with heterogeneous persistence.
Nationalization through Internationalization. Writing, Remembering, and Commemorating the Holocaust in Macedonia and Bulgaria after 1989
Authors: Ragaru Nadège 
Published: July 2017

Abstract
The author analyses the scholarship, remembrance, and commemoration of the Holocaust in Macedonia and Bulgaria after 1989. She re-examines interpretive schisms between former communists and anticommunists, explores changes in one of the major lieux de mémoire in Bulgaria, the ‘rescue’ of its Jews, and juxtaposes it to the killing of those Jews who lived in Bulgarian-occupied territories. She contextualizes the Bulgarian-Macedonian controversies within European and global frameworks, looking at the process of the institutionalization of Holocaust remembrance in the two countries. She then considers the role of international Jewish communities and the effects of a European Union that since the enlargement of 2007 has been moulding a ‘European’ commemorative landscape from fear of yet another East-West divide. In her conclusion the author outlines an agenda for a transnational social history of anti-Jewish policies and persecutions, and looks at who might be its major actors in Bulgaria and Macedonia.
The Greek Historiography of the 1940s. A Reassessment
Authors: Voglis Polymeris , Nioutsikos Ioannis 
Published: July 2017

Abstract
This article is a presentation and assessment of Greek historiography and public memory regarding the period of occupation, resistance, and civil war during the 1940s. It examines historical production and culture from the first postwar years until 1989 and explains the relation between the changing visions of the past and political developments in Greece. In addition, the article evaluates works published after 2000, in order to discuss new questions that were raised and the ensuing debates. The article concludes by addressing themes that can revitalize the study of the 1940s, regarding the analytical framework, the territorial and social dimension, the notion of state and governmentality, and the issue of memory and public history.
From Heroisation to Competing Victimhoods. History Writing on the Second World War in Moldova
Authors: Suveica Svetlana 
Published: July 2017

Abstract
The author outlines the way identity perspectives determine the understanding of World War Two in Moldovan society, and the role of historians in this conception. She discusses how historians have adjusted their writing to fit a certain political discourse and have influenced how and what should people ‘remember’. Further questions at stake touch on the standing of Moldovan history writing in comparison with World War Two research published outside the country; the new tendencies in history writing; and whether these emerging currents might lead in the near future to the transcendence of the politicised approaches that are currently dominant.
Academic Freedom in Danger. Fact Files on the ‘CEU Affair’
Authors: Trencsényi Balázs , Rieber Alfred J. , Iordachi Constantin , Hîncu Adela 
Published: July 2017

Abstract
In the beginning of April this year, the Hungarian Parliament passed two amendments to the existing educational law, which in their particular formulation targeted specifically the renowned Central European University in Budapest and sought to undermine the legal basis of its existence in Hungary. In four contributions leading academics and a PhD student of the History Department of the Central European University place the latest events in context, provide insights into the institutional set-up and the development of the History Department, and explain why this institution is special and worth fighting for.
Application of Response Surface Methods To Determine Conditions for Optimal Genomic Prediction
Authors: Howard Réka , Carriquiry Alicia L , Beavis William D 
Published: July 2017

AbstractAn epistatic genetic architecture can have a significant impact on prediction accuracies of genomic prediction (GP) methods. Machine learning methods predict traits comprised of epistatic genetic architectures more accurately than statistical methods based on additive mixed linear models. The differences between these types of GP methods suggest a diagnostic for revealing genetic architectures underlying traits of interest. In addition to genetic architecture, the performance of GP methods may be influenced by the sample size of the training population, the number of QTL, and the proportion of phenotypic variability due to genotypic variability (heritability). Possible values for these factors and the number of combinations of the factor levels that influence the performance of GP methods can be large. Thus, efficient methods for identifying combinations of factor levels that produce most accurate GPs is needed. Herein, we employ response surface methods (RSMs) to find the experimental conditions that produce the most accurate GPs. We illustrate RSM with an example of simulated doubled haploid populations and identify the combination of factors that maximize the difference between prediction accuracies of best linear unbiased prediction (BLUP) and support vector machine (SVM) GP methods. The greatest impact on the response is due to the genetic architecture of the population, heritability of the trait, and the sample size. When epistasis is responsible for all of the genotypic variance and heritability is equal to one and the sample size of the training population is large, the advantage of using the SVM method vs. the BLUP method is greatest. However, except for values close to the maximum, most of the response surface shows little difference between the methods. We also determined that the conditions resulting in the greatest prediction accuracy for BLUP occurred when genetic architecture consists solely of additive effects, and heritability is equal to one.
The role of metastin in pathogenesis of genital endometriosis
Authors: Aylamazyan Edvard K. , Yarmolinskaya Mariya I. , Ganbarli Nigar F. , Tkachenko Natalia N. , Tolibova Gulrukhsor Kh. , Tral Tatyana G. , Rulev Viktor V. , Tsipurdeeva Anna A. 
Published: July 2017

Materials and methods. 28 patients with GE of I-II degrees of prevalence (R-AFS) were included in the study. Control group consisted of 11 healthy women. All the patients underwent laparoscopy and hysteroscopy with histological examination of ovarian tissue, peritoneum and endometrium; patients with GE also were performed histological examination of endometrioid of heterotopies. Definition of levels of kisspeptin, FSH, LH, prolactin, AMH, estradiol, estrone, androgens (free testosterone, dehydroepiandrosterone – DHEA) in peripheral blood in healthy women and in patients with GE were conducted by ELISA on the 2nd and 8th days of menstrual cycle. Immunohistochemical method was used to evaluate expression of metastine (kisspeptin) and its receptor in ovarian tissue, peritoneum, in endometrioid heterotopies and in endometrium.
Results. Hormonal survey has revealed that the level of kisspeptin in peripheral blood was reliably higher compared to its level in the control group. Immunohistochemical study found that in patients with GE area of expression of KISS and KISS1R receptor in endometrium was reliably lower when compared with these values in the control group. In the foci of endometrioid heterotopies, which were located on the pelvic peritoneum, it was observed a reliable increase in protein КІЅЅ1 expression and receptor KISS1R compared to fragments of intact peritoneum. The area of expression of receptor KISS1R in endometrioid heterotopies was reliably higher than the area of its expression in endometrium of patients with GE and in endometrium of women of the control group. Direct correlation between the area of protein expression (KISS) in endometrium with level kisspeptin on the 8th day of menstrual cycle in peripheral blood (rs = 0,90) has been revealed. It has been determined that the level of kisspeptin on the 2nd day of menstrual cycle in peripheral blood correlates with the area of expression of receptor KISS1R in peritoneum (rs = 0,57). A direct correlation between the area of expression of receptor KISS1R in peritoneum with the level of kisspeptin on the 8th day of menstrual cycle in serum has been found (rs = 0,90).
Conclusion. The obtained data show a definite role of kisspeptin in pathogenesis of genital endometriosis. It can be assumed that the increase in the level of metastine (kisspeptin) in peripheral blood and increased expression of KISS1 in endometrioid heterotopies and especially its receptor KISS1R are compensatory-adaptive response aimed at deterrence of further spread of endometriosis. The obtained results justify the need to continue research in this direction for a deeper understanding of pathogenesis of the disease and possible use of kisspeptin as biomarker for non-invasive diagnostics as well as potential targeted therapy of GE.
New approaches to the estimation of endometrial dysfunction
Authors: Aylamazyan Edvard K. , Tolibova Gulrukhsor Kh. , Tral Tatyana G. , Kogan Igor U. , Yarmolinskaya Mariya I. , Tsipurdeeva Anna A. , Rodichkina Valeriia R. , Kvetnoy Igor M. 
Published: July 2017

Introduction. The application of modern methods for assessing the morphofunctional state of the endometrium to verify and study the expression of sex steroid hormones, proinflammatory markers and markers of angiogenesis using confocal laser scanning microscopy will allow an objective study of the role of studied markers in the pathogenesis of the endometrial dysfunction.
The aim of the study was to evaluate the expression of ER and PR receptors in endometrium in patients with endometrial dysfunction.
Material and methods. Endometrial biopsy specimens obtained with the aid of a pile-biopsy or a scraping from the uterine cavity are used to conduct the method of immunofluorescent confocal laser scanning microscopy. It is possible to use both cryostat material and paraffin blocks to provide the immunohistochemical analysis. Monoclonal antibodies to ER (1 : 60, Dako, Denmark) and PR (1 : 50, Dako, Denmark) are used as primary antibodies, antibodies conjugated with fluorochrome Alexa Fluor 647 (1 : 1000, Abcam, England) are used as secondary antibodies). Hoechst 33258 (Sigma, USA) is used for staining of cell nuclei.
Results. A method of confocal laser scanning microscopy makes it possible to conduct qualitative and quantitative evaluation of the studied markers in different structures of the endometrium.
Body composition indices and tissue loss in patients with resectable gastric adenocarcinoma
Authors: Aahlin Eirik Kjus , Irino Tomoyuki , Johns Neil , Brismar Torkel , Nilsson Magnus , Revhaug Arthur , Lassen Kristoffer 
Published: July 2017

AbstractBackgroundBody composition analyses from computed tomography (CT) scans have been used to assess cachexia in cancer patients. We investigated body composition indices, tissue change and treatment outcome in patients with resectable gastric adenocarcinoma.MethodsA cohort analysis of all patients treated with curative intent for gastric adenocarcinoma in two Scandinavian university hospitals from 2008–2011 was performed (n=137). Body composition analyses were performed on CT images taken for routine diagnostics and staging. Both preoperative single scans and repeat CT examinations were analyzed.ResultsPerioperative chemotherapy was given to 58 (42.3%) patients. Forty patients (29.2%) suffered severe postoperative complications and 70 (51.1%) patients died within three years. There was a significant reduction in patients' lean tissue during neoadjuvant chemotherapy (p=0.001). There was no association between skeletal muscle tissue index and postoperative complications. Poorer survival was observed in patients with preoperative skeletal muscle tissue index within the lowermost quartile, independent of tumor characteristics and neoadjuvant treatment (HR=1.91, 95% CI 1.11–3.28, p=0.019).ConclusionsPatients lost lean tissue during neoadjuvant treatment for gastric adenocarcinoma. Low preoperative skeletal muscle index was not associated with postoperative complications, but strongly associated with poorer survival.
Lean body mass, muscle fibre size and muscle function in cancer patients during chemotherapy and 10 weeks exercise
Authors: Lønbro Simon , Farup Jean , Bentsen Signe , Voss Thomas , Rittig Nikolaj , Wang Jakob , Ørskov Morten , Højris Inger , Mikkelsen Ulla Ramer 
Published: July 2017

AbstractBackgroundChemotherapy can reduce muscle mass in cancer patients but the potential of exercise to ameliorate this is understudied, particularly at the myocellular level. The primary purpose was to investigate changes in lean body mass (LBM) and secondly single fibre cross‐sectional area (CSA) in cancer patients during chemotherapy and in combination with 10 weeks of exercise.MethodsIn a single‐arm trial, patients adhered to chemotherapy for at least 4 weeks (control period) before 10 weeks of exercise adjunct to chemotherapy (exercise period). LBM (Dual Energy X‐ray Absorptiometry) and single fibre CSA (muscle biopsies) were assessed at baseline, pre‐ and post‐exercise. Muscle strength, functional performance and aerobic capacity were also assessed.ResultsTen patients were included, however only six patients completed the protocol. LBM changed over time (p=0.013), but no significant changes were observed between specific time points. Numerically, LBM decreased by 0.3 kg (p=0.41, 95% CI: ‐1.1;0.5) from 41.3–41.0kg, during the control period and increased by 0.7 kg (p=0.16, 95% CI: ‐0.6;2.0) from 40.4–41.1 kg during exercise. Muscle fibre CSA did not change significantly over time (p=0.13), but decreased numerically in the control period by 703 μm2 (p=0.20, 95% CI: ‐1877; 470) and increased by 846 μm2 (trend, p=0.08, 95% CI: ‐162; 1854) following exercise. Muscle strength and functional performance were unchanged during the control period but improved post‐exercise.ConclusionsDespite non‐significant changes in muscle mass (due to small sample size), this study adds novel information on LBM and myocellular changes in cancer patients during chemotherapy and concurrent exercise.
THE ROLE OF THE SCHOOL SPACE IN PRESCHOOLERS' LEARNING PROCESSES
Authors: Močinić Snježana , Feresin Catina 
Published: July 2017

Purpose of the study
The first aim of the present article was to investigate the role of school environment as an important factor in the learning process of children attending preschools in Istria (i.e. a part of Croatia where many people speak Italian).
The school space is also called “Third educator” by famous pedagogues and it is constituted by labs, corridors, materials shape of the building, colours of the walls, quality of the lightings, type of furnishings and all didactic materials. It is a specific environment where the children live, learn, experience, get in touch with other people.
Methodology
The method used in our research was both quantitative as qualitative analyses of pedagogical documentation, observation of the environment of preschools and interviews with the educational boards of every school.
Results
The results showed that the school space is mostly in accordance with the requirements of the current legislation of the Country of Croatia and also confirmed the importance of it as “Third educator”, especially when the educators themselves were able to ameliorate the richness of corners and materials made available for children, encouraging in this way the development of the child's independence, maturation of identity and development of competencies.
Implications
In conclusion, school environment significantly affects child's learning, both because of the influence of architectural structures as because relational contexts and stimuli offered by the environment and by the educators. It means that the Ministry of Education in any Country should pay attention to the way buildings are constructed, especially regarding the richness of corners and materials at disposal of the children and of the educators.