bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating genome-wide association studies and gene expression data highlights dysregulated multiple sclerosis risk pathways
Authors: Liu Guiyou , Zhang Fang , Jiang Yongshuai , Hu Yang , Gong Zhongying , Liu Shoufeng , Chen Xiuju , Jiang Qinghua , Hao Junwei 
Published: May 2016

Background: Much effort has been expended on identifying the genetic determinants of multiple sclerosis (MS). Existing large-scale genome-wide association study (GWAS) datasets provide strong support for using pathway and network-based analysis methods to investigate the mechanisms underlying MS. However, no shared genetic pathways have been identified to date. Objective: We hypothesize that shared genetic pathways may indeed exist in different MS-GWAS datasets. Methods: Here, we report results from a three-stage analysis of GWAS and expression datasets. In stage 1, we conducted multiple pathway analyses of two MS-GWAS datasets. In stage 2, we performed a candidate pathway analysis of the large-scale MS-GWAS dataset. In stage 3, we performed a pathway analysis using the dysregulated MS gene list from seven human MS case–control expression datasets. Results: In stage 1, we identified 15 shared pathways. In stage 2, we successfully replicated 14 of these 15 significant pathways. In stage 3, we found that dysregulated MS genes were significantly enriched in 10 of 15 MS risk pathways identified in stages 1 and 2. Conclusion: We report shared genetic pathways in different MS-GWAS datasets and highlight some new MS risk pathways. Our findings provide new insights on the genetic determinants of MS.
Cortical functional modifications following optic neuritis
Authors: Benoliel Tal , Raz Noa , Ben-Hur Tamir , Levin Netta 
Published: May 2016

Background: We have recently suggested that delayed visual evoked potential (VEP) latencies in the fellow eye (FE) of optic neuritis patients reflect a cortical adaptive process, to compensate for the delayed arrival of visual information via the affected eye (AE). Objective: To define the cortical mechanism that underlies this adaptive process. Methods: Cortical activations to moving stimuli and connectivity patterns within the visual network were tested using functional magnetic resonance imaging (MRI) in 11 recovered optic neuritis patients and in 11 matched controls. Results: Reduced cortical activation in early but not in higher visual areas was seen in both eyes, compared to controls. VEP latencies in the AEs inversely correlated with activation in motion-related visual cortices. Inter-eye differences in VEP latencies inversely correlated with cortical activation following FE stimulation, throughout the visual hierarchy. Functional correlation between visual regions was more pronounced in the FE compared with the AE. Conclusion: The different correlation patterns between VEP latencies and cortical activation in the AE and FE support different pathophysiology of VEP prolongation in each eye. Similar cortical activation patterns in both eyes and the fact that stronger links between early and higher visual areas were found following FE stimulation suggest a cortical modulatory process in the FE.
Applying the guidelines for pharmacists integrating into primary care teams
Authors: Barry Arden R. , Pammett Robert T. 
Published: May 2016

Background: In 2013, Jorgenson et al. published guidelines for pharmacists integrating into primary care teams. These guidelines outlined 10 evidence-based recommendations designed to support pharmacists in successfully establishing practices in primary care environments. The aim of this review is to provide a detailed, practical approach to implementing these recommendations in real life, thereby aiding to validate their effectiveness. Methods: Both authors reviewed the guidelines independently and ranked the importance of each recommendation respective to their practice. Each author then provided feedback for each recommendation regarding the successes and challenges they encountered through implementation. This feedback was then consolidated into agreed upon statements for each recommendation. Results and Discussion: Focusing on building relationships (with an emphasis on face time) and demonstrating value to both primary care providers and patients were identified as key aspects in developing these new roles. Ensuring that the environment supports the practice, along with strategic positioning within the clinic, improves uptake and can maximize the usefulness of a pharmacist in primary care. Demonstrating consistent and competent clinical and documentation skills builds on the foundation of the other recommendations to allow for the effective provision of clinical pharmacy services. Additional recommendations include developing efficient ways (potentially provider specific) to communicate with primary care providers and addressing potential preconceived notions about the role of the pharmacist in primary care. Conclusion: We believe these guidelines hold up to real-life integration and emphatically recommend their use for new and existing primary care pharmacists.
Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary
Authors: Arora Ripla , Abby Emilie , Ross Adam D. J. , Cantu Andrea V. , Kissner Michael D. , Castro Vianca , Ho Hsin-Yi Henry , Livera Gabriel , Laird Diana J. 
Published: May 2016

ABSTRACT
Mouse ovarian germ cells enter meiosis in a wave that propagates from anterior to posterior, but little is known about contribution of germ cells to initiation or propagation of meiosis. In a Ror2 mutant with diminished germ cell number and migration, we find that overall timing of meiotic initiation is delayed at the population level. We use chemotherapeutic depletion to exclude a profoundly reduced number of germ cells as a cause for meiotic delay. We rule out sex reversal or failure to specify somatic support cells as contributors to the meiotic phenotype. Instead, we find that anomalies in the distribution of germ cells as well as gonad shape in mutants contribute to aberrant initiation of meiosis. Our analysis supports a model of meiotic initiation via diffusible signal(s), excludes a role for germ cells in commencing the meiotic wave and furnishes the first phenotypic demonstration of the wave of meiotic entry. Finally, our studies underscore the importance of considering germ cell migration defects while studying meiosis to discern secondary effects resulting from positioning versus primary meiotic entry phenotypes.
Properties of Juvenile and Mature Wood and Their Effects on the Bending Properties of Lumber in Pinus taeda Growing in Tochigi, Japan
Authors: Tanabe Jun , Ishiguri Futoshi , Nakayama Miki , Ohshima Jyunichi , Iizuka Kazuya , Yokota Shiso 
Published: May 2016

Abstract
Five 40-year-old Pinus taeda trees growing in Tochigi, Japan, were used to evaluate juvenile wood (JW) and mature wood (MW) properties and the bending properties of lumber. The boundary between JW and MW existed from the 14th to the 19th ring from pith in the sample trees. There were obvious differences in wood properties between the JW and MW: the MW had higher values in the latewood percentage and basic density and lower values in the microfibril angle. The microfibril angle and the air-dry density were closely related to the bending properties of the JW lumber and the MW lumber, respectively.
Selected Medication Safety Risks to Manage in 2016–Part I Intravenous Fat Emulsion Needs a Filter
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: May 2016

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Efficacy and Safety of High-Dose Subcutaneous Unfractionated Heparin Prophylaxis for the Prevention of Venous Thromboembolism in Obese Hospitalized Patients
Authors: Beall Jeffrey , Woodruff Ashley , Hempel Carolyn , Wovkulich Margaret , Zammit Kimberly 
Published: May 2016

Background Obese patients experience a higher risk of venous thromboembolism (VTE) than their nonobese counterparts, which may warrant a more aggressive approach to thromboprophylaxis in this population. Objective The purpose of this study was to compare rates of nosocomial VTE in obese patients treated with high-dose versus conventional-dose subcutaneous unfractionated heparin sodium (UFH) for thromboprophylaxis. Methods A retrospective, single-center, cohort study was conducted to evaluate obese, adult, hospitalized patients admitted between April 2011 and April 2014 who received heparin 5,000 or 7,500 units subcutaneously every 8 hours for thromboprophylaxis. The primary outcome assessed the rate of nosocomial VTE in obese patients treated with high-dose heparin (7,500 units subcutaneously q 8 h) versus conventional-dose heparin (5,000 units subcutaneously q 8 h). Additionally, a secondary outcome assessed safety by quantifying bleeding events. Results Nosocomial VTE occurred in 2/196 (1.02%) patients who received high-dose heparin thromboprophylaxis and in 5/2,182 (0.23%) patients who received conventional-dose heparin ( p = .05). Bleeding occurred in 0/196 (0%) patients in the high-dose heparin group and in 2/2,182 (0.09%) patients in the conventional-dose heparin group ( p = .67). All bleeding events were minor. Conclusions This study failed to demonstrate a statistically significant reduction in the rate of nosocomial VTE in obese patients who received high-dose heparin thromboprophylaxis. Despite receiving a higher heparin dose, no increased risk of bleeding was observed in the high-dose group. Further investigation is needed to identify the optimal heparin dose for thromboprophylaxis in obese patients.
Stability of an Extemporaneously Compounded Oral Suspension of Bosentan
Authors: Malik Alina , Gorman Gregory , Coward Lori , Arnold John J. 
Published: May 2016

Purpose To assess the stability of an extemporaneously compounded oral suspension of bosentan from commercially available tablets for a period of 1 month. Methods A 6.25 mg/mL oral suspension of bosentan monohydrate was prepared from Tracleer tablets. The bosentan suspension was then evenly divided between 2 light-resistant prescription bottles and stored in the dark either under refrigeration (4–8°C) or at controlled room temperature (21–26°C). The suspensions were assessed for physical changes (ease of resuspendability, change in color, change in odor), and samples were drawn immediately after preparation and on days 0, 1, 3, 7, 10, 14, 21, 28, and 31. Samples were analyzed at each time point by high-performance liquid chromatography (HPLC) utilizing a reversed-phase column with chemical stability defined as the retention of at least 90% of the initial intact bosentan concentration measured. Results No change in suspendability, color, or odor of the compounded bosentan suspensions was noted throughout the storage period. Furthermore, regardless of storage conditions, the oral suspension of bosentan retained at least 94% of the active pharmaceutical ingredient for 31 days after preparation. Conclusion The results of our study indicate that a 6.25 mg/mL bosentan oral suspension stored in the dark under refrigeration and at room temperature maintains physical and chemical stability for 1 month.
Crime, Community, and Human Rights in Southeastern Nigeria, Then and Now
Authors: Jell-Bahlsen Sabine 
Published: May 2016

Abstract
This article addresses crime and punishment in relation to community and human rights in southeastern Nigeria based on thirty years of observations complemented by additional research. A 1987 crime and its punishment in a rural community are providing a contrast to four violent incidents, their punishment, the absence of a trial, and other human rights violations prevalent in the area. Igbo culture and its socioeconomic and political institutions as well as its religious beliefs and ethics once provided the basis for a person’s identity, economic security, and communal safety; the culture enabled prevention and punishment of crime within the community. This situation has changed drastically; the community has lost its clout; the people are disempowered by transnational corporations in collaboration with the nation-state and within the political economy of oil; the indigenous culture is dismantled, indigenous beliefs and ethics are depreciated, and violent crime is now prevalent and committed without impunity and on all levels of society. Human Rights Watch and other international organizations are pointing to potential solutions on the governmental and administrative levels. However, the socioeconomic situation, political economy, cultural-spiritual and individual issues must also be taken into account and addressed, calling for further research towards finding a way out of the current dilemma.
Consumer Health Informatics: Past, Present, and Future of a Rapidly Evolving Domain
Authors: Demiris G. 
Published: May 2016

Summary
Objectives: Consumer Health Informatics (CHI) is a rapidly growing domain within the field of biomedical and health informatics. The objective of this paper is to reflect on the past twenty five years and showcase informatics concepts and applications that led to new models of care and patient empowerment, and to predict future trends and challenges for the next 25 years.
Methods: We discuss concepts and systems based on a review and analysis of published literature in the consumer health informatics domain in the last 25 years.
Results: The field was introduced with the vision that one day patients will be in charge of their own health care using informatics tools and systems. Scientific literature in the field originally focused on ways to assess the quality and validity of available printed health information, only to grow significantly to cover diverse areas such as online communities, social media, and shared decision-making. Concepts such as home telehealth, mHealth, and the quantified-self movement, tools to address transparency of health care organizations, and personal health records and portals provided significant milestones in the field. Conclusion: Consumers are able to actively participate in the decision-making process and to engage in health care processes and decisions. However, challenges such as health literacy and the digital divide have hindered us from maximizing the potential of CHI tools with a significant portion of underserved populations unable to access and utilize them. At the same time, at a global scale consumer tools can increase access to care for underserved populations in developing countries. The field continues to grow and emerging movements such as precision medicine and the sharing economy will introduce new opportunities and challenges.
Ontology optimization tactics via distance calculating
Authors: Gao Yun , Farahani Mohammad Reza , Gao Wei 
Published: May 2016

Abstract
In this article, we propose an ontology learning algorithm for ontology similarity measure and ontology mapping in view of distance function learning techniques. Using the distance computation formulation, all the pairs of ontology vertices are mapped into real numbers which express the distance of their corresponding vectors. The more distance between two vertices, the smaller similarity between their corresponding concepts. The stabilities of our learning algorithm are defined and several bounds are yielded via stability assumptions. The simulation experimental conclusions show that the new proposed ontology algorithm has high efficiency and accuracy in ontology similarity measure and ontology mapping in certain engineering applications.
Contact Impact Forces at Discontinuous 2-DOF Vibroimpact
Authors: Bazhenov V.A. , Pogorelova O.S. , Postnikova T.G. 
Published: May 2016

Abstract
Dynamic behaviour of contact impact forces in strongly nonlinear discontinuous vibroimpact system is studying. Contact impact force is one of the most significant vibroimpact system characteristics. We investigate the 2-DOF vibroimpact system by numerical parameter continuation method in conjunction with shooting and Newton-Raphson methods. We simulate the impact by nonlinear contact interactive force according to Hertz’s contact law. This paper is the continuation of the previous works [1,2]. We have determined the instability zones and bifurcations points for loading curves [1] and frequency-amplitude response [2] under variation of excitation amplitude and frequency. In this paper we investigate the behaviour of contact forces at bifurcation points particularly at discontinuous bifurcation points where set-valued Floquet multipliers cross the unit circle by jump that is their moduli becoming more than unit by jump. It is phenomenon unique for nonsmooth systems with discontinuous right-hand side. We observe also the contact forces increase at nT -periodical multiple impacts regimes. We also learn the change of contact forces behaviour when the impact between system bodies became the soft one due the change of system parameters.
Finite Element Analysis of Influence of Non-homogenous Temperature Field on Designed Lifetime of Spatial Structural Elements under Creep Conditions
Authors: Pyskunov S.O. , Maksimyk Yu.V. , Valer V.V. 
Published: May 2016

Abstract
The techniques of modeling of continual fracture process for spatial bodies under long-term static force loading condition in non-homogenous temperature field are presented. The scalar damage parameter is used to describe the material continual fracture process. A stress-strain problem solution made with semianalytic finite element method (SFEM). Results of lifetime determination of responsible parts are presented.
Effect of the Affordable Care Act on Racial and Ethnic Disparities in Health Insurance Coverage
Authors: Buchmueller Thomas C. , Levinson Zachary M. , Levy Helen G. , Wolfe Barbara L. 
Published: May 2016

Objectives. To document how health insurance coverage changed for White, Black, and Hispanic adults after the Affordable Care Act (ACA) went into effect.Methods. We used data from the American Community Survey from 2008 to 2014 to examine changes in the percentage of nonelderly adults who were uninsured, covered by Medicaid, or covered by private health insurance. In addition to presenting overall trends by race/ethnicity, we stratified the analysis by income group and state Medicaid expansion status.Results. In 2013, 40.5% of Hispanics and 25.8% of Blacks were uninsured, compared with 14.8% of Whites. We found a larger gap in private insurance, which was partially offset by higher rates of public coverage among Blacks and Hispanics. After the main ACA provisions went into effect in 2014, coverage disparities declined slightly as the percentage of adults who were uninsured decreased by 7.1 percentage points for Hispanics, 5.1 percentage points for Blacks, and 3 percentage points for Whites. Coverage gains were greater in states that expanded Medicaid programs.Conclusions. The ACA has reduced racial/ethnic disparities in coverage, although substantial disparities remain. Further increases in coverage will require Medicaid expansion by more states and improved program take-up in states that have already done so.
Emotional Feedback and the Viral Spread of Social Media Messages About Autism Spectrum Disorders
Authors: Bail Christopher A. 
Published: May 2016

Objective. To determine whether exchanges of emotional language between health advocacy organizations and social media users predict the spread of posts about autism spectrum disorders (ASDs). Methods. I created a Facebook application that tracked views of ASD advocacy organizations' posts between July 19, 2011, and December 18, 2012. I evaluated the association between exchanges of emotional language and viral views of posts, controlling for additional characteristics of posts, the organizations that produced them, the social media users who viewed them, and the broader social environment. Results. Exchanges of emotional language between advocacy organizations and social media users are strongly associated with viral views of posts. Conclusions. Social media outreach may be more successful if organizations invite emotional dialogue instead of simply conveying information about ASDs. Yet exchanges of angry language may contribute to the viral spread of misinformation, such as the rumor that vaccines cause ASDs.
Quantitative Bias Analysis in Regulatory Settings
Authors: Lash Timothy L. , Fox Matthew P. , Cooney Darryl , Lu Yun , Forshee Richard A. 
Published: May 2016

Nonrandomized studies are essential in the postmarket activities of the US Food and Drug Administration, which, however, must often act on the basis of imperfect data. Systematic errors can lead to inaccurate inferences, so it is critical to develop analytic methods that quantify uncertainty and bias and ensure that these methods are implemented when needed. “Quantitative bias analysis” is an overarching term for methods that estimate quantitatively the direction, magnitude, and uncertainty associated with systematic errors influencing measures of associations. The Food and Drug Administration sponsored a collaborative project to develop tools to better quantify the uncertainties associated with postmarket surveillance studies used in regulatory decision making. We have described the rationale, progress, and future directions of this project.