bluuebunny/crossref_metadata_2025_split huggingface dataset:
AQP2‐Induced Acceleration of Renal Cell Proliferation Involves the Activation of a Regulatory Volume Increase Mechanism Dependent on NHE2
Authors: Rivarola Valeria , Di Giusto Gisela , Christensen María José , Ford Paula , Capurro Claudia 
Published: May 2016

ABSTRACTWe have previously shown in renal cells that expression of the water channel Aquaporin 2 (AQP2) increases the rate of cell proliferation by shortening the transit time through the S and G2/M phases of the cell cycle. This acceleration is due, at least in part, to a down‐regulation of regulatory volume decrease (RVD) mechanisms when volume needs to be increased in order to proceed into the S phase. We hypothesize that in order to increase cell volume, RVD mechanisms may be overtaken by regulatory volume increase mechanisms (RVI). In this study, we investigated if the isoform 2 of the Na+/H+ exchanger (NHE2), the main ion transporter involved in RVI responses, contributed to the AQP2‐increased renal cell proliferation. Three cortical collecting duct cell lines were used: WT‐RCCD1 (not expressing AQPs), AQP2‐RCCD1 (transfected with AQP2), and mpkCCDc14 (with inducible AQP2 expression). We here demonstrate, for the first time, that both NHE2 protein activity and expression were increased in AQP2‐expressing cells. NHE2 inhibition decreased cell proliferation and delayed cell cycle progression by slowing S and G2/M phases only if AQP2 was expressed. Finally, we observed that only in AQP2‐expressing cells a NHE2‐dependent RVI response was activated in the S phase. These observations suggest that the AQP2‐increased proliferation involves the activation of a regulatory volume increase mechanism dependent on NHE2. Therefore, we propose that the accelerated proliferation of AQP2‐expressing cells requires a coordinated modulation of the RVD/RVI activity that contributes to cell volume changes during cell cycle progression. J. Cell. Biochem. 118: 967–978, 2017. © 2016 Wiley Periodicals, Inc.
Step‐Growth Polymerizing Systems of General Type “AfiBgi”: Calculating the Bivariate (Molecular Size) × (Number of Branch Points) Weight Distribution Using Generating Functions and Recurrences
Authors: Hillegers L. Tom , Slot Johan J. M. 
Published: May 2016

This study considers step‐growth polymerizing systems of general type “AfiBgi” whereby one or more of the reacting monomer species bear at least three reactive groups. The random polymerization process will lead to a population of polymer molecules in which the individual molecules may differ widely with respect to degree of polymerization and number of branch points. This study presents an algorithmic method to calculate the statistical distribution of weight over these two molecular properties. The method uses bivariate generating functions, recurrences, and integer arithmetic.image
Great expectations: racial differences in outcome expectations for a weight lifting intervention among black and white breast cancer survivors with or without lymphedema
Authors: Dean Lorraine T. , Brown Justin , Coursey Morgan , Schmitz Kathryn H. 
Published: May 2016

AbstractBackgroundBlack breast cancer survivors are less likely to engage in physical activity than are White survivors. This is unfortunate because physical activity may be especially beneficial given Black breast cancer survivors' higher rates of obesity and adverse treatment effects related to obesity, such as breast cancer‐related lymphedema (BCRL). The analysis explored outcome expectations for a weight lifting intervention by sedentary Black or White female breast cancer survivors and assessed the role of BCRL on outcome expectations for exercise.MethodsChi‐squared tests compared mean outcome expectation values for Black and White breast cancer survivors who completed baseline surveys for the Physical Activity and Lymphedema trial (n = 281). With race as the independent variable, multivariable analysis compared results for women without BCRL with those with BCRL, separately.ResultsAcross the entire sample, Black survivors (n = 90) had significantly higher (p < 0.05) outcome expectations than White survivors (n = 191) for improvements in sleep, appearance, mental health, affect, energy, and eating habits, with small to moderate effect sizes. When stratified by BCRL status, differences by race were robust only among those with BCRL.ConclusionsBlack cancer survivors had greater expectations than White cancer survivors for how a weight lifting intervention would improve their physical and mental states; these differences were most apparent among women with BCRL. Improving outcomes in Black breast cancer survivors rests on the development of interventions that are appropriately tailored to address the expectations of this population and account for differences in persistent adverse effects of cancer such as BCRL. Copyright © 2016 John Wiley & Sons, Ltd.
Correlation among selected fracture‐mechanical parameters of concrete obtained from experiments and inverse analyses
Authors: Zimmermann Thomas , Lehký David , Strauss Alfred 
Published: May 2016

AbstractThe correlations among selected parameters of concrete were investigated for concrete mixes of the strength classes C20/25, C25/30, C30/37, C40/50 and C50/60. The focus was laid on correlations between basic mechanical parameters such as compressive strength, tensile strength and modulus of elasticity as well as parameters related to concrete fracture, represented here by specific fracture energy. Laboratory tests examining the fracture behaviour and mechanical properties were carried out in order to determine the fundamental concrete parameters. In particular, standard compression tests on test cubes and three‐point bending tests on beams with central edge notch were performed. Additional material parameters were identified using the inverse analysis technique. Finally, correlation factors between different parameters of concrete were identified using the rank‐order correlation method.
Experimental and numerical evaluation of proposed precast concrete connections
Authors: Yekrangnia Mohammad , Taheri Amir , Zahrai Seyed Mehdi 
Published: May 2016

AbstractIn this article, the cyclic performance of an innovative precast beam‐to‐column connection is evaluated experimentally and numerically. Two full‐scale beam‐column cross‐shape interior connection specimens named PF‐1 and PF‐2 are tested. By adding extra nuts to the connecting bolts, specimen PF‐2 behaves in a more shear‐dominant pattern and shows less pinching. Comparison of performance of these specimens with the numerical monolithic model in terms of stiffness, strength, ductility and energy dissipation capacity indicates the proposed system can provide conditions close to the monolithic connection. However, to reduce the pinching drawback, a minor modification was made leading to performance improvements in strength and equivalent viscous damping ratio up to 51% and 29% respectively. The results of this study have direct industrial relevance and may be used for the development of reliable seismic guidelines for precast concrete structures.
Numerical analysis of a bridge pier subjected to truck impact
Authors: Jiříček Pavel , Foglar Marek 
Published: May 2016

AbstractThe impact of heavy trucks on a bridge substructure can lead to progressive collapse of the bridge superstructure, and to disastrous accidents. This type of load should therefore be taken into consideration, especially in the design of motorway bridges. For some structural arrangements, vehicle impact is the decisive loading for the design of the bridge substructure. This paper presents verification of the detailed procedures given by European standard EN 1991‐1‐7 for bridge pier impact load – dynamic ana lysis, which is compared with the outcomes from a detailed finite‐element model (FEM) of a truck impact prepared using AUTODYN software. A nonlinear material model of concrete with damage and strain‐rate effect is used to assess the impact performance of a bridge pier. The paper further presents the results of a numerical study focused on the influence of different types of bridge pier reinforcement arrangement on their resistance to vehicle impact. The performance of various types of reinforcement is analysed and compared. Practical recommendations are drawn for the design of bridge piers which can be subjected to vehicle impacts in an urban environment.
The Hernia–Neck‐Ratio (HNR), a Novel Predictive Factor for Complications of Umbilical Hernia
Authors: Fueter T. , Schäfer M. , Fournier P. , Bize P. , Demartines N. , Allemann P. 
Published: May 2016

AbstractBackgroundUmbilical hernia is a common pathology and surgical repair is advised to prevent complications in symptomatic patients. However, risk factors that predict such advert events are unknown. The aim of the study was to determine whether morphological characteristics are associated with the occurrence of complications.MethodRetrospective review of adult patients with elective and emergent umbilical hernia repair operated from January 2004 to December 2013. The size of the hernia and the size of the neck were measured based on operative reports, ultrasound, CT or MRI images. The Hernia–Neck‐Ratio (HNR) was then calculated as novel risk indicator.Results106 patients underwent umbilical hernia repair (70 for uncomplicated and 36 for complicated hernia) as single procedure. The median size of the hernia sac was statistically significantly smaller in the uncomplicated group (30 mm, interquartile range (IQR) 20–49 vs. 50 mm, IQR 40–71, p = 0.037). The median size of the neck was not different between both groups (15 mm, IQR 11–29 vs. 16 mm, IQR 12–21, p = 0.44). The median HNR was smaller in the uncomplicated group (1.76, IQR 1.45–2.18 vs. 3.33, IQR 2.97–3.91, p = 0.00026). Based on ROC curve analysis (area under the curve: 0.9038), a cut‐off value of 2.5 was associated with 91 % sensitivity and 84 % specificity.ConclusionsA novel predictive factor for complications related to umbilical hernia is proposed. The Hernia–Neck Ratio can easily be calculated. These results suggest that umbilical hernia with HNR >2.5 should be operated, irrespective of the presence of symptoms.
Nanoemulsification of Ceramide‐2 by Sodium Dilauramidoglutamide Lysine, a Novel Peptide‐Based Gemini Surfactant
Authors: Tian Yonghong , Guo Yiguang , Yang Xuefang , Zhang Wanping 
Published: May 2016

AbstractA novel peptide‐based gemini surfactant, namely, sodium dilauramidoglutamide lysine (DLGL) was employed to fabricate a stable nanoemulsion system for the delivery of hydrophobic bioactive ceramide‐2 molecules. The phase properties and morphology and stability of the nanoemulsion were investigated by focusing on the interaction between DLGL and ceramide‐2 molecules. The investigation of the phase properties of the mixture of DLGL and ceramide‐2 by X‐ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy revealed remarkable reduction in the crystallinity of ceramide‐2 due to the presence of DLGL. The spherical shape and nanometer size of nanoemulsions emulsified by DLGL were characterized by scanning electron microscopy and transmission electron microscopy. The nanoemulsions prepared using DLGL exhibited significant improvement in the dispersion stability without any significant changes in the particle sizes even after storing them for a month at 50 °C. The results indicated that DLGL readily associated with ceramide‐2 to form a relatively stable structure. The steric hindrance of DLGL and molecular rearrangement of DLGL and ceramide‐2 attributed to a break in the continuity of the molecular assembly of ceramide‐2, which hampered its crystallinity.
Satisfaction and Quality of Life Related to Chemotherapy with an Arm Port: A Pilot Study
Authors: Burbridge Brent , Chan Ian Y.M. , Bryce Rhonda , Lim Hyun J. , Stoneham Grant , Haggag Hager , Roh Christine 
Published: May 2016

Purpose Placement of arm ports, or totally implanted venous access devices, is a common practice in our interventional radiology suite. We implant a miniaturized port in the upper arm for the provision of long-term chemotherapy. We hypothesized that there was general satisfaction with these arm ports and they have a minimal negative impact on quality of life. In this study we aimed to assess our hypotheses. Methods We surveyed subjects, who having previously received an arm port for chemotherapy to treat a malignancy, attended the interventional room for its removal. The survey assessed the port's effect on lifestyle, the degree of device-related pain, the acceptance of the port, and the willingness to have another port in the future. Results Survey responses from 77 subjects were reviewed. On a scale of 1 (most negative) to 10 (most positive), respondents indicated that the port system was a very positive enhancement to their treatment (satisfaction = 9.2 ± 2.0 and positivity = 8.8 ± 2.2). The port had little impact on daily activities. The mean score for the likelihood of choosing to have another port placed if additional treatment was required was 9.1 ± 2.1. Discussion The arm port in this study did not negatively impact subject satisfaction and quality of life for this cohort. Most subjects rated the device utility highly and felt that the port was a positive enhancement to their treatment, one that they would possibly utilise again in future, if need be.
Protective effects of BMP‐7 against tumor necrosis factor α‐induced oligodendrocyte apoptosis
Authors: Wang Xin , Xu Jun‐Mei , Wang Ya‐Ping , Yang Lin , Li Zhi‐Jian 
Published: May 2016

AbstractBone morphogenic protein‐7 (BMP7) is a multifunctional cytokine with demonstrated neurogenic potential. Oligodendrocytes (OLs) death after spinal cord injury (SCI) contributes to demyelination of spared axons, even leading to a permanent neurological deficit. Therefore, therapeutic approaches to prevent OLs death after SCI should be considered. Since the effects of BMP7 on OLs after injury are largely unknown, we demonstrated the effects of BMP7 on TNF‐α‐induced OLs apoptosis in vitro. The effects of BMP7 on TNF‐α‐induced OLs apoptosis were verified by flow cytometry, spectrophotometry and western blotting on primary cultures from spinal cord of postnatal day 1 (P1) to P2 rats. As shown by flow cytometry, apoptosis rate was 25.6% for the control group, 59.0% for the TNF‐α group, and 33.5% for the BMP7 + TNF‐α group; spectrophotometry showed caspase‐3 and caspase‐8 activity were significantly increased in the TNF‐α group than in the control group, and BMP7 could reverse the increase. The involvement of cIAP1 in the protection of BMP7 was determined by western blotting and silencing cIAP1. In summary, our results demonstrated that BMP7 could potently inhibite TNF‐α‐induced OLs apoptosis and identified the cIAP1 expression level, the activity of caspase‐3 and caspase‐8 as important mediators of OLs survival after cellular stress and cytokine challenge.
Textual paralanguage and its implications for marketing communications
Authors: Luangrath Andrea Webb , Peck Joann , Barger Victor A. 
Published: May 2016

AbstractBoth face‐to‐face communication and communication in online environments convey information beyond the actual verbal message. In a traditional face‐to‐face conversation, paralanguage, or the ancillary meaning‐ and emotion‐laden aspects of speech that are not actual verbal prose, gives contextual information that allows interactors to more appropriately understand the message being conveyed. In this paper, we conceptualize textual paralanguage (TPL), which we define as written manifestations of nonverbal audible, tactile, and visual elements that supplement or replace written language and that can be expressed through words, symbols, images, punctuation, demarcations, or any combination of these elements. We develop a typology of textual paralanguage using data from Twitter, Facebook, and Instagram. We present a conceptual framework of antecedents and consequences of brands' use of textual paralanguage. Implications for theory and practice are discussed.
Aerobic Exercise Combined With Noninvasive Positive Pressure Ventilation Increases Serum Brain‐Derived Neurotrophic Factor in Healthy Males
Authors: Kawazu Takamitsu , Nakamura Takeshi , Moriki Takashi , Kamijo Yoshi‐ichiro , Nishimura Yukihide , Kinoshita Tokio , Tajima Fumihiro 
Published: May 2016

AbstractBackgroundBrain‐derived neurotrophic factor (BDNF) has been implicated in enhancing neuronal health. Exercise and noninvasive positive‐pressure ventilation (NPPV) are known to independently alter BDNF levels in patients with depression, dementia, type 2 diabetes, chronic obstructive pulmonary disease, and obstructive sleep apnea syndrome. However, the combined effects of exercise and NPPV on serum BDNF in normal subjects are unknown.ObjectiveTo determine the effects of the combination of acute aerobic exercise under NPPV on serum BDNF in normal adults.DesignCross‐over design study.SettingWakayama Medical University.ParticipantsTen healthy young men.InterventionThe subjects exercised on a cycle ergometer at 60% of pretraining maximal oxygen uptake (O2max) for 30 minutes daily for 5 consecutive days with or without NPPV (12 cmH2O). The 5‐day exercise protocol was repeated after a 3‐week washout period with or without NPPV.Main Outcome MeasurementsSerum BDNF, plasma cortisol, and platelet, lymphocyte, and monocyte counts were measured at 24 hours before the first day exercise with or without NPPV and 24 hour after last day exercise with or without NPPV at resting condition. Measurements were also made on the first day exercise; serum BDNF level was measured immediately before and immediately after exercise, as well as at 1, 2, and 3 hours after exercise with or without NPPV.ResultsThe 5‐day exercise protocol significantly (P < .05) increased serum BDNF when combined with NPPV, but not without NPPV, and did not change plasma cortisol level, platelet, or lymphocyte counts, with or without NPPV. The 5‐day exercise protocol also significantly (P < .05) decreased monocyte count without NPPV, but not with NPPV, relative to baseline. Changes noticed immediately after the first day of exercise included significant (P < .05) increase in serum BDNF compared with immediately before the exercise, with or without NPPV.ConclusionsThe results indicated that a 5‐day exercise protocol combined with NPPV increased serum BDNF, suggesting that NPPV synergistically enhances the effect of aerobic exercise on serum BDNF level.Level of EvidenceII
Do Multiple Concussions Lead to Cumulative Cognitive Deficits? A Literature Review
Authors: Yumul Joy Noelle , McKinlay Audrey 
Published: May 2016

AbstractA concussion is an important health concern for children and adolescents, particularly in the context of sporting injuries. Some research suggests a cumulative effect from multiple concussions (also referred to as mild traumatic brain injury), which creates a dilemma when considering how to manage children and young persons who may experience multiple concussive events within a sporting season. However, there is very little research regarding the outcomes of multiple concussions and their optimal management. The purpose of this review is to evaluate the evidence regarding the cognitive outcomes of multiple concussions. After assessing the eligibility of the articles from the literature search, 7 studies were identified and included in the review. In most of the available literature, the cognitive outcomes related to multiple concussions are measured during the same developmental age as when the injuries happened. Moreover, most studies that investigated multiple concussions are focused on sports‐related injuries, and only some are conducted in children and adolescents in the general population. The current evidence is inconclusive; whereas some studies reported adverse outcomes, others reported null findings. The studies that reported adverse or cumulative effects based their findings on worse cognitive outcomes, more subjective symptoms, and prolonged recovery postinjury.Level of EvidenceII
Screening for History of Traumatic Brain Injury Among Women Exposed to Intimate Partner Violence
Authors: Goldin Yelena , Haag Halina L. , Trott Charlotte T. 
Published: May 2016

AbstractTraumatic brain injury (TBI) is a common chronically debilitating consequence of intimate‐partner violence (IPV). Diagnosis and effective treatment are precluded by poor detection and lack of uniform practice guidelines for TBI screening in IPV. Although there are several TBI‐screening tools commonly used in clinical and research practices, their applicability to this unique and vulnerable population is unclear. In this review paper, we propose a theoretically based framework for screening for history of TBI in women exposed to IPV and apply it to investigate the applicability of TBI‐screening instruments. The framework was developed by examining existing guidelines for working with IPV survivors and applied to evaluate the content of nine currently available TBI screening instruments to determine the extent to which each offers (1) events that can lead to TBI in an IPV situation; (2) safe (without increasing the risk of retaliation) endorsement of an event; and (3) ease of administration. Our evaluation of the currently available TBI‐screening tools determined that no instrument met the proposed framework standards and only 2 (Brain Injury Screening Questionnaire and Ohio State University TBI Identification Method) came close, requiring only minor adjustments to meet the postulated criteria. We make specific content and interview‐based recommendations for revising TBI screening instruments to minimize the weaknesses of currently available screening tools among women exposed to IPV and the knowledge gaps about TBI in this context. The proposed framework and recommendations are intended to guide future work in this area to enhance the capacity of TBI screening tools to safely detect TBI in this population.Level of EvidenceV
The Resurgence of The Arab Cold War
Authors: Lawson Fred H. 
Published: May 2016

AbstractMalcolm H. Kerr's classic study The Arab Cold War appeared in print in a circuitous way, which can be traced using archival materials that have previously been inaccessible to scholars. More important, the primary analytical themes of the book continue to be fundamentally misrepresented, despite the frequent appropriation of the book's title by students of regional affairs in the wake of the 2010–11 uprisings.