bluuebunny/crossref_metadata_2025_split huggingface dataset:
Infectious disease surveillance in Dutch hospitals: what’s in it for us?
Authors: Marbus Sierk D. , Boere Tjarda M. , Veldhuijzen Irene K. , Gageldonk-Lafeber Arianne B. van 
Published: October 2024

Abstract

Background
The COVID-19 pandemic has shown the need for multipurpose and sustainable hospital surveillance data. We studied barriers, facilitators, and preferred requirements for an infectious disease surveillance system in Dutch hospitals to be valuable and feasible from a hospital perspective.
Methods
This study is part of a larger EU4Health Project, UNITED4Surveillance. Semi-structured interviews with key stakeholders were conducted, and were subsequently analyzed using a thematic analytic approach.
Results
Participants discussed surveillance systems regarding antimicrobial resistance, healthcare-associated infections, and severe acute respiratory infections. Perceived barriers to establishing or maintaining such systems included unclear and/or passive hospital roles, legal challenges, and insufficient resources and capacity. Perceived facilitators included clinically relevant and actionable data, mutually beneficial collaborations between stakeholders, and sufficient support at multiple decision-making levels and across legal, technical, capacity, and financial domains.
Conclusions
This qualitative research provides new insights in the experienced barriers and facilitators for infectious diseases surveillance in Dutch hospitals from the hospital perspective since the end of the COVID-19 pandemic. Key stakeholders outlined practical recommendations to improve robust and sustainable infectious disease surveillance in Dutch hospitals: i) ensure clinically relevant actionable data; ii) clarify roles and responsibilities; and iii) collaborate on innovative initiatives.
Development and validation of a simulation task for quantitatively assessing oral cancer resection skills
Authors: Sakamoto Kayo , Mitani Sohei , Nishio Naoki , Kitani Takashi , Sato Eriko , Tanaka Keiko , Ugumori Toru , Wakisaka Hiroyuki , Hato Naohito 
Published: October 2024

Abstract

Purpose: To develop and validate an oral cancer simulation task that could quantitatively assess tumor resection skills.
Methods: This prospective study employed Messick’s contemporary framework. A focus group of six board-certified head and neck surgeons facilitated articulation of experts' understanding of oral cancer resection into two primary categories: "ensuring adequate margins" and "maintaining safety." According to the results, we developed a simulation task. "Ensuring adequate margins" in oral cancer resection was assessed using extracted phantom-model specimens; "maintaining safety" during electrosurgery was assessed by the degree of tumor bed carbonization during electrosurgery. The validity evidence sources of the task were gathered from questionnaire responses and quantitative measurements obtained by performing the task.
Results: Ten expert surgeons completed the questionnaire after performing the task. The replication of oral cancer resection was rated highly (4.4 out of 5), and experts agreed with quantitative measures used to assess surgeons' skills (4.8 out of 5). Five experts and 12 students performed the task, and their skills were measured. The internal consistency of the measures was good (Cronbach’s alpha: 0.803). Margin error distances were significantly smaller for experts than for students (P<0.0001). Spectral colorimetric analysis revealed that lesser tumor bed carbonization was achieved by experts than by students (P<0.0001). Principal component analysis showed that experts’ performance was stable, whereas students’ skill was varied.
Conclusions: We developed an oral cancer simulation task to quantitatively measure surgeons’ skills. Using this simulation task may promote early acquisition of tumor resection skills and improve outcomes for oral cancer patients.
Synergistic Flame Retardant effect of Boron-Coated Expandable Graphite(BEG) and AmmoniumPolyphosphate(APP) in Rigid Polyurethane Foam(RPUF)
Authors: Bhatt Gnanu G , Soni Daxit 
Published: October 2024

Abstract

In this research Boron-Coated expandable graphite(BEG) and ammonium polyphosphate(APP) are used as a combination, to improve Flame retardant property of Rigid polyurethane foam. To study synergist effect of both the materials (Boron-Coated expandable graphite(BEG) and ammonium polyphosphate(APP)) on the Rigid polyurethane foam (RPUF), horizontal burning test along with limiting oxygen index (LOI) tests are used. Both the test methods help to evaluate improvement in flame retardancy property of RPUF.
Small intestinal γδ T17 cells promote C1q-mediated SAE by synaptic pruning in mice
Authors: Zhang Jiancheng , Wu Yuming , Zhang Yujing , Yu Yuan , Zhen Zifan , Wang Xin , Yuan Yin , Xie Bing , Han Mengqi , Wang Mengyuan , Zhang Xinyu , Sun Xueqiang , Wen Xiaoyue , Shang You , Hashimoto Kenji , Yuan Shiying 
Published: October 2024

Abstract

Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear. Our research demonstrates that sepsis could induce the migration of IL-7Rhigh CD8low γδ T17 cells from the small intestine to the meninges, where they secrete IL-17A, impairing mitochondrial function in microglia and activating the cGAS-STING-C1q pathway. This process is accompanied by inhibited ubiquitination of STING at the K150 site, resulting in STING accumulation and increased release of C1q-tagged hippocampal synapses, which are subsequently pruned by activated microglia. Importantly, 4-Octyl itaconate mitigates the excessive synaptic pruning by inhibiting γδ T17 cell migration and promoting STING ubiquitination, thereby alleviating SAE. Our findings reveal a novel mechanism of synaptic pruning by microglia via the cGAS-STING-C1q pathway, emphasize the critical role of gut-derived γδ T17 cell migration to the meninges in SAE, and highlight the importance of STING ubiquitination in modulating C1q-mediated excessive synaptic pruning.
Cancellous bone thickness in the distal fragment affects the severity of dorsal angulated distal radius fractures
Authors: Sato Kotaro , Murakami Kenya , Takahashi Gaku , Mimata Yoshikuni , Matsuura Masanori 
Published: October 2024

Abstract

Introduction
A fall with an extended wrist leads to distal radius fractures (DRFs). The sharing force between the carpus and the volar cortex causes volar-sharing fractures. Therefore, a sharing force between the carpus and the dorsal cortex could be generated in dorsally angulated DRFs. In cases of trauma, a moderate force may cause a non-articular fracture, while a stronger force could result in an articular fracture. We speculate that maintaining a thick cancellous bone in the distal fragment could help dissipate the force and potentially prevent articular fractures. We hypothesized that the cancellous thickness of the subchondral bone affects the development of intra-articular fractures. This study thus investigated the radiological parameters of DRFs to verify the development of intra-articular fractures.
Materials and Methods
We retrospectively reviewed 199 patients with dorsally angulated DRFs for whom reconstructed computed tomography images were available. Articular fracture patterns were evaluated in the axial planes. We measured cancellous thickness under the subchondral bone in the sagittal plane. Moreover, we compared the radial inclination, volar tilt, ulnar variance, and cancellous thickness among groups with types A, C1/2, and C3 DRFs.
Results
A fracture line running from the sigmoid notch to the dorsal extensor compartment accounted for approximately 80% of DRF cases. Ulnar variance was significantly larger in the type C3 group than in the type A group. Cancerous thickness was significantly smaller in the type C than in the type A group.
Conclusions
The sharing force between the carpus and the proximal dorsal cortex is one of the main causes of intra-articular fractures in dorsally angulated DRFs. Thicker cancellous bone in distal fragments protects the articular cartilage from the load.
Soil organic carbon and its relation with the reflectance spectroscopy in soil sampling by layers and compound in the Depositional Piedmont of Villavicencio (Colombia)
Authors: Díaz Nubia Cristina , Jola Jorge , Darghan Aquiles , Rubiano Yolanda , Galindo Juan Pablo 
Published: October 2024

Abstract

Monitoring and quantifying soil organic carbon content in different landscapes at different sampling depths is crucial to assessing the quality of soil, water and the functionality of the ecosystems that are established there. Monitoring results can guide practices that could be adopted to improve soil organic carbon storage and thus enhance and diversify ecosystem services. Inventories of soil organic carbon stocks at local level can be used to assess compliance with international climate change conventions. In the case of the Depositional Piedmont of Villavicencio (Colombia), the results of the integrated principal component variance analysis in spectral reflectance data with subsequent spatial modelling did not show differences in importance either at different depths of soil sampling or in the landscapes themselves, but showed a clear relationship of soil organic carbon content to bulk density and weighted average reflectance of the 1506.93-1846.38 nm band mainly, followed by the 1000.00-1245.02 nm band. This proposed methodology is simple to adopt and can be used involving a larger set of factors that may be associated with reflectance in experimental or observational data structures.
Calculating the effect of intensive use of urban organic waste on soil concentrations of potentially toxic elements in a peri-urban agriculture context in Norway
Authors: Løes Anne-Kristin , Eiter Sebastian , Rittl Tatiana 
Published: October 2024

Abstract

Background
Recycling nutrients and organic matter available as waste in urban areas may close nutrient gaps and improve soil quality, but the concentrations of potentially toxic elements (PTEs) are commonly higher than in mineral fertilisers. How quickly may the limits for soil quality be exceeded, and for which elements, if such materials are applied intensively? For a rough answer to this question, we used soil data from ten case farms near Oslo and Bergen (Norway) to estimate how PTE concentrations increased when the demand for nitrogen (N), phosphorus (P) and potassium (K) in a theoretical carrot crop produced every year was covered by compost or digestate from source-separated food waste, or composted garden waste, compared with manure from horses and poultry which are often kept in peri-urban areas.
Results
With the intensive fertilisation assumed here, the Norwegian soil quality limits for PTEs were reached within 20-85 years, and faster for soil with more organic matter since regulatory limits set by weight discriminate soils with low bulk density. The limits were reached first for Cu and Zn, which are both essential micronutrients for crop plants. The concentrations of macronutrients in the urban waste-based fertilisers were not well balanced. Rates covering the K demand would lead to high surpluses of P and N. In peri-urban vegetable growing, high applications of compost are not unusual, but more balanced fertilisation is required.
Conclusions
The Norwegian regulations for PTEs in organic soil amendments and agricultural soil are stricter than in the EU, and do not support recycling of organic matter and nutrients from urban waste. Many materials which can only be applied with restricted amounts to Norwegian agricultural soil, may be applied according to crop demand in the EU.
Growers utilising urban waste-based fertilisers intensively should monitor the soil regularly, including PTE analyses. Soil sampling should occur on fixed sampling points to reveal changes in concentrations over time.
Norwegian authorities should consider a revision of the organic fertiliser regulation to support recycling of valuable organic materials. There is a need for more data on the PTE concentrations in agricultural soil and organic fertiliser materials.
Immune and microbial signatures in immunocompetent and immunocompromised patients with pneumonia
Authors: Zhan Yangqing , Zhou Jiemin , Li Shaoqiang , Hu Bingxue , Du Qiuling , Wang Haodi , Li Zhengtu , Sun Wenjun , Yang Juhua , Qiu Ye , Yang Zifeng , Chen Rongchang , Ye Feng 
Published: October 2024

Abstract

Background Pneumonia is a common acute respiratory infection that contributes to significant mortality and morbidity worldwide. The disruption of the airway microbiome in respiratory infection has been extensively reported. However, whether the changes in respiratory tract microbial communities during pneumonia were related to disease severity remains elusive. Herein, we aimed to investigate the correlation between the changes in airway microbiome and immune response in pneumonia patients. Methods We performed metagenomic and metatranscriptomic sequencing on immunocompetent (ICO) and immunocompromised host (ICH) with pneumonia using bronchoalveolar lavage fluid (BALF), blood, sputum, and swab samples. Results Compared to ICO patients with pneumonia, ICH patients had higher Pneumonia Severity Index (PSI) score. BALF metagenomic and metatranscriptomic sequencing showed higher microbial diversity in ICH patients, while ICH patients exhibited lower microbial diversity in sputum samples. Additionally, pneumonia patients with different PSI scores exhibited different microbial communities. Relative abundance of Human Gammaherpesvirus 4 (EBV) was positively correlated with PSI score. For ICH patients, BALF metatranscriptomic sequencing found 183 up-regulated genes and 85 down-regulated genes in EBV-detected group compared with EBV not-detected group, while there was no significant difference in ICO patients, indicating that EBV might be reactivated in ICH patients, while EBV might be latent in ICO patients. In ICH patients, we observed significant down-regulation of immune related genes and interferon stimulated genes in EBV-detected group compared to the not-detected group, including CSF1R, CXCR6, IL10, IL16, and TNFRSF25. Co-occurrence network analysis found positive correlations between EBV and Citrobacter freundii or Campylobacter concisus, indicating that synergistic effects on exacerbating the severity of pneumonia might exist between EBV and these two microbes. Conclusion EBV might be considered as a microbial signature for disease severity, which could regulate immune-related signaling pathways. Notably, we unravel that EBV presence might inhibit the immune response of hosts, reduce anti-inflammatory responses, and increase the possibilities of infections caused by other pathogens, exacerbating the pneumonia severity.
Clinical Outcomes of Posterior Hindfoot Endoscopic Surgery Using 1.9-mm Diameter Needle Arthroscopy for Posterior Ankle Impingement in Athletes
Authors: Shimozono Yoshiharu , Mori Daisuke , Mizuno Yasuyuki , Funakoshi Noboru , Kobayashi Masahiko , Matsuda Shuichi , Yamashita Fumiharu 
Published: October 2024

Abstract

Introduction
Posterior hindfoot endoscopy is a safe and effective treatment for posterior ankle impingement syndrome (PAIS). However, data on the outcomes of needle arthroscopy for PAIS in athletes are still lacking. The purpose of this study is to investigate the clinical outcomes and return to sports following hindfoot endoscopic surgery utilizing 1.9-mm diameter needle arthroscopy in the treatment of PAIS, especially in athletes, including ballet dancers.
Materials and Methods
A retrospective cohort study was conducted to evaluate patients who underwent hindfoot endoscopic surgery using 1.9-mm diameter needle arthroscopy for PAIS between 2021 and 2023. Clinical outcomes were evaluated preoperatively and 12 months after surgery using the Japanese Society for Surgery of the Foot (JSSF) scale and the Self-Administered Foot Evaluation Questionnaire (SAFE-Q). The time to return to sports training, and complete return to sports activities were also evaluated.
Results
Thirteen patients (5 male and 8 female) with a mean age of 21.1 years were included. The mean follow-up time was 17.1 months. Sports activities included ballet (7 patients), soccer (3 patients), lacrosse (2 patients), and tennis (1 patient). The mean JSSF scale significantly improved from 79.1 preoperatively to 98.3 at the final follow-up (p < 0.001). The mean SAFE-Q scores improved significantly postoperatively in all subscales, except the shoe-related subscale. The mean time to return to sports-specific training was 3.8 weeks. All patients were able to return to full sports activities, and the mean time to return to full sports activities at the pre-injury levels was 6.3 weeks. The ballet dancers returned to full activity at the pre-injury levels at a mean time of 7.3 weeks.
Conclusions
Posterior hindfoot endoscopy employing 1.9-mm diameter needle arthroscopy demonstrated excellent clinical outcomes in the management of PAIS, with patients experiencing a relatively earlier return to sports, including ballet dancers.
Level of Evidence: Level IV, case series
Reducing anaphylaxis reactions and enhancing antiarthritic effects of folate-conjugated sinomenine-loaded human serum albumin nanoparticles in experimental inflammation and arthritis
Authors: Liu Jianxin , Liu Mei , Jiang Shan , Li Shuang , Deng Yong , Chen Xuan , Li Jiaxuan , Wang Min , Guo Jiaying , Ouyang Fan , Xiao Jiafu , Wu Weihua , Jin An , Xiang Yinhong , hua zhou 
Published: October 2024

Abstract

Precision targeted delivery system based on nanomaterials is a feasible strategy to address anaphylaxis reactions of natural products. By loading sinomenine (SIN) into folate (FA) modified human serum albumin (HSA) nanomaterials, triple targeting including extravasation through leaky vasculature and subsequent Inflammatory cell-mediated sequestration (ELVIS) targeting, secreted protein acidic and rich in cysteine (SPARC) targeting and M1 macrophage targeting can be achieved, and the occurrence of anaphylaxis reactions can be reduced, so that SIN can be accurately delivered to rheumatoid arthritis (RA) joints. FA-SIN-HSA NPs exhibited potent anti-inflammatory activity and analgesic effect, and the possibility of inducing anaphylaxis reactions was extremely slight. FA-SIN-HSA NPs were also able to specifically target RA joints to prolong the circulating half-life of SIN as confirmed by highperformance liquid chromatography (HPLC) and in vivo fluorescence imaging. After collagen-II induced arthritis (CIA) mice were treated with FA-SIN-HSA NPs, the symptoms were greatly relieved, and the RA therapeutic effect was excellent. Taking this case as a reference, for anaphylaxis reactions of natural products, natural products can be loaded in nanomaterials modified with targeted modifiers to enhance the therapeutic effect and reduce anaphylaxis reactions.
Effects of Pemafibrate on Cardio-Ankle Vascular Index (CAVI) in Patients with Type 2 Diabetes or Ischemic Heart Disease: A 24-Week Observational Study
Authors: Watanabe Yasuhiro , Nonaka Shoya , Yamaoka Shuhei , Nakamura Shoko , Horikawa Osamu , Yamaguchi Takashi , Sato Shuji , Todani Shunsuke , Sugizaki Yuta , Ito Takuro , Mikamo Hiroshi , Takahashi Mao , Nagayama Daiji , Shimizu Kazuhiro , Saiki Atsuhito 
Published: October 2024

Abstract

Background: Pemafibrate is a novel selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) that improves lipid profile, but its effects on cardiovascular events remain unproven. This study examined changes in the cardio-ankle vascular index (CAVI), a marker of arterial stiffness, in high-risk patients with type 2 diabetes mellitus (T2DM) or ischemic heart disease (IHD) treated with pemafibrate.
Methods: In this single-center, prospective, observational study, 95 patients with T2DM and/or IHD, who had hypertriglyceridemia (≥150 mg/dL) and started pemafibrate (0.2 mg/day) were analyzed. The primary outcome was change in CAVI after 24 weeks. Secondary outcomes included changes in lipid profile, apolipoproteins, and liver enzymes.
Results: No significant change in CAVI was observed after 24 weeks of treatment (median [interquartile range (IQR)]; baseline vs 24 weeks: CAVI 9.4 [8.8-10.6] vs. 9.6 [8.9-10.8], p=0.715). However, pemafibrate significantly reduced triglycerides (233 mg/dL [171-329] to 143 mg/dL [111-187], p<0.001), apolipoprotein C-II (8.1 mg/dL [6.1-10.2] to 6.3 mg/dL [5.3-8.3], p<0.001), apolipoprotein C-III (15.3 mg/dL [12.2-18.3] to 11.6 mg/dL [9.3-14.2], p<0.001) and liver enzymes; and increased high-density lipoprotein cholesterol (45 mg/dL [39-52] to 50 mg/dL [40-60], p<0.001), apolipoprotein A-I and apolipoprotein A-II (both p<0.05). Calculated small dense low-density lipoprotein cholesterol also decreased significantly (40 mg/dL [31-49] to 36 mg/dL [28-45], p=0.002).
Conclusion: Although pemafibrate improves lipid profile and liver enzymes, its direct impact on vascular stiffness, as measured by CAVI, may be limited in short-term treatment. Further studies with extended follow-up are necessary to clarify its potential cardiovascular benefits, particularly in high-risk patients with T2DM and/or IHD.
Detection of the First Icing Roads in Winter: The Case of Gümüşhane City (Türkiye)
Authors: Işık Fatih , Çağlak Savaş , Eraslan Selim , Zeybek Halil İbrahim , Kanyılmaz Rabia 
Published: October 2024

Abstract

This study aims to assess the risks of ice and snowfall in Gümüşhane city center during the winter months. Icing poses serious risks to vehicular and pedestrian traffic in winter, and understanding and managing this situation is critical for urban safety. The study area covers various neighborhoods and streets within Gümüşhane's city limits in the Eastern Black Sea Region of Türkiye. The materials and methods used include Geographic Information Systems (GIS) techniques, field studies, and analysis of meteorological data. We evaluated various parameters such as solar radiation, slope, precipitation, temperature, and elevation using GIS techniques. Field studies identified icing risks in shaded areas, sloping terrain, and congested streets, and recorded coordinate information for precise localization. The study determined that areas with narrow and high-rise buildings, known as "urban canyons," have a particularly high risk of icing. We observed icing more frequently and intensely in these areas due to the inability of sunlight to reach them. The lack of sunlight exacerbated the frequency and intensity of icing in these regions. Additionally, the formation of hidden icing as a result of melting snow and ice in sloping areas was also an important finding. In conclusion, the winter risks identified in this study are critical for traffic safety in Gümüşhane city center during the winter months. These findings may be used by the municipality and related institutions to guide their winter season plans. This approach aims to ensure safe transportation in the city during the winter season.