bluuebunny/crossref_metadata_2025_split huggingface dataset:
Semiautomated Surveillance of Deep Surgical Site Infections After Primary Total Hip or Knee Arthroplasty
Authors: Sips Meander E. , Bonten Marc J. M. , van Mourik Maaike S. M. 
Published: April 2017

Manual surveillance of surgical site infections (SSIs) after total hip or knee arthroplasty is time-consuming and prone to error. Semiautomated surveillance based on routine care data extracted from electronic health records can retrospectively identify deep SSIs and substantially reduce workload while maintaining 100% sensitivity.Infect Control Hosp Epidemiol2017;38:732–735
Effects of the flavonol quercetin andα-linolenic acid onn-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial
Authors: Burak Constanze , Wolffram Siegfried , Zur Berndt , Langguth Peter , Fimmers Rolf , Alteheld Birgit , Stehle Peter , Egert Sarah 
Published: April 2017

AbstractIncreased dietary intake and tissue status of the long-chainn-3 PUFA, EPA and DHA, is associated with cardiovascular benefits. Epidemiological and animal studies suggest that concomitant nutritive intake of flavonoids may increase the conversion ofα-linolenic acid (ALA) to longer-chainn-3 fatty acids EPA and DHA. We investigated the effects of increased ALA intake on fatty acid composition of serum phospholipids and erythrocytes in metabolically healthy men and women and whether fatty acid profiles and ALA conversion were affected by regular quercetin intake or sex. Subjects (n74) were randomised to receive at least 3·3 g/d ALA with either 190 mg/d quercetin (ALA+quercetin) or placebo (ALA+placebo) in a double-blinded, placebo-controlled, crossover trial with 8-week intervention periods separated by an 8-week washout period. A total of seven subjects dropped out for personal reasons. Data from the remaining sixty-seven subjects (thirty-four males and thirty-three females) were included in the analysis. Both interventions significantly increased serum phospholipid ALA (ALA+placebo: +69·3 %; ALA+quercetin: +55·8 %) and EPA (ALA+placebo: +37·3 %; ALA+quercetin: +25·5 %). ALA + quercetin slightly decreased DHA concentration by 9·3 %. Erythrocyte ALA and EPA significantly increased with both interventions, whereas DHA decreased. Fatty acid composition did not differ between sexes. We found no effect of quercetin. Intake of 3·6 g/d ALA over an 8-week period resulted in increased ALA and EPA, but not DHA, in serum phospholipids and erythrocytes. Neither quercetin supplementation nor sex affected the increment of ALA and relative proportions ofn-3 PUFA in serum phospholipids and erythrocytes.
THE LOCALITY PRINCIPLE IN PRIVATE NUISANCE
Authors: Steel S. 
Published: April 2017

Abstract
This article considers the principle in the tort of private nuisance that the level of protection to which one is entitled from certain kinds of interference is sensitive to one's locality. It argues that the principle can be partly justified by the different costs of avoiding an interference which different localities create. However, it shows that, if the principle is to be justified in its entirety, a further justification is necessary. The article considers further justifications based on social rules, autonomy, cost minimisation, the idea of a system of equal right and an analogy to the rules on hypersensitive claimants. It largely rejects these explanations and concludes that, to the extent the locality principle requires individuals to bear substantial burdens that they would not have to bear were collective interests set aside, without compensation, it is difficult to justify.
Heating in ultraintense laser-induced shock waves
Authors: Eliezer Shalom , Pinhasi Shirly Vinikman , Martinez Val José Maria , Raicher Erez , Henis Zohar 
Published: April 2017

AbstractThis paper considers the heating of a target in a shock wave created in a planar geometry by the ponderomotive force induced by a short laser pulse with intensity higher than 1018 W/cm2. The shock parameters were calculated using the relativistic Rankine–Hugoniot equations coupled to a laser piston model. The temperatures of the electrons and the ions were calculated as a function of time by using the energy conservation separately for ions and electrons. These equations are supplemented by the ideal gas equations of state (with one or three degrees of freedom) separately for ions and electrons. The efficiency of the transition of the work done by the laser piston into internal thermal energy is calculated in the context of the Hugoniot equations by taking into account the binary collisions during the shock wave formation from the target initial condition to the compressed domain. It is shown that for each laser intensity there is threshold pulse duration for the formation of a shock wave. The explicit calculations are done for an aluminum target.
An efficient stochastic approach for robust time-optimal trajectory planning of robotic manipulators under limited actuation
Authors: Zhao Ming-Yong , Gao Xiao-Shan , Zhang Qiang 
Published: April 2017

SUMMARYThis paper focuses on the problem of robust time-optimal trajectory planning of robotic manipulators to track a given path under a probabilistic limited actuation, that is, the probability for the actuation to be limited is no less than a given bound κ. We give a general and practical method to reduce the probabilistic constraints to a set of deterministic constraints and show that the deterministic constraints are equivalent to a set of linear constraints under certain conditions. As a result, the original problem is reduced to a linear optimal control problem which can be solved with linear programming in polynomial time. In the case of κ = 1, the original problem is proved to be equivalent to the linear optimal control problem. Overall, a very general, practical, and efficient algorithm is given to solve the above problem and numerical simulation results are used to show the effectiveness of the method.
IMPLICIT LEARNING IN THE CROWD
Authors: Kerz Elma , Wiechmann Daniel , Riedel Florian B. 
Published: April 2017

AbstractA growing field of research has made use of a semiartificial language paradigm to investigate the role of awareness in L2 acquisition. A central and empirically still unresolved issue in this field concerns the possibility of learning implicitly, that is, without intention to learn and without awareness of what has been learned. Up until now, studies on implicit learning have mainly been conducted in laboratory settings under highly controlled conditions with university students as participants. The present study investigated whether and to what extent the results obtained in such settings can be extrapolated to the general population. Building on Williams (2005), we designed two crowdsourcing experiments that examined the learning of novel form-meaning mappings under incidental conditions in 163 participants. Our design allowed us to disentangle the effects of awareness at the level of noticing and understanding. The results of the two experiments demonstrated the implicit learning effect outside the lab in a more varied sample of participants and indicated that awareness at both levels appears to have a facilitative effect on learning outcomes.
Molecular characterisation ofSalmonellastrains isolated from outbreaks and sporadic cases of diarrhoea occurred in Paraná State, South of Brazil
Authors: ASSIS F. E. A. , DALLAGASSA C. B. , FARAH S. M. S. S. , SOUZA E. M. , PEDROSA F. O. , CHUBATSU L. S. , FADEL-PICHETH C. M. T. 
Published: April 2017

SUMMARYA total of 46 strains ofSalmonellaisolated from patients with sporadic diarrhoea or involved in foodborne outbreaks were analysed by PCR for genus identification and serotyping. Subtyping was performed using pulsed-field gel electrophoresis (PFGE) and multiple amplification of phage locus typing (MAPLT) for seven variable loci. Bacteria were identified as belonging to serotype Enteritidis (33 strains; 71·7%) or Typhimurium (13 strains; 28·3%). A high similarity coefficient (94·6%) was observed in theSalmonellaEnteritidis group for which were found three related PFGE profiles and only one MAPLT; strains representing profile PA/P1/MI were prevalent (27; 81·8%). TwoSalmonellaTyphimurium isolates were untypeable by PFGE. The remaining 11 strains had eight PFGE and three MAPLT profiles. The discriminatory power of MAPLT was lower than that of PFGE.SalmonellaEnteritidis of clonal nature is predominant in Paraná State, with the most prevalent profile PA/P1/M1 associated with sporadic diarrhoea and with seven of nine reported outbreaks. In conclusion, PFGE shows higher discriminatory power amongSalmonellastrains.
CERAMIC ROOF ORNAMENTS (ALMENAS) FROM CIHUATAN, EL SALVADOR: CONTEXTS, DESCRIPTIONS, AND INFERENCES FROM OTHER SITES
Authors: Becker Marshall Joseph 
Published: April 2017

AbstractDiscovery of dozens of broken ceramic roof ornaments (almenas) on the floor abutting the front (western) margin of an elite residence (Structure Q-1) at Cihuatan, El Salvador provides a new context for this category of artifacts. While relatively well-known from sites in the Valley of Mexico, elsewhere in Mesoamericaalmenashave been documented only from a single Teotihuacan-style structure at the lowland Maya site of Tikal, one structure at Mayapan, and possibly at a few other sites in Yucatan. A preliminary program to reconstruct a portion of the many box-likealmenasat Cihuatan, of a date much later than the one from Tikal, generated seven relatively complete examples of this form, indicated that fragments of perhaps another 50 had been recovered, and that they were used in pairs. The reconstructed sample provides an important demonstration of the ornamentation on an elite residence and also reveals much about how Structure Q-1 and surrounding buildings came to an end, arounda.d.1200. At least eight other buildings at Cihuatan had been adorned withalmenas,each building having examples of one specific shape, possibly unique to this city. Comparisons with Aztec and earlier Mexican forms suggest cultural connections, perhaps via Tula. These findings strongly suggest Mexican influences for the use and forms of roof ornaments at Cihuatan.
Seed removal by different functional mammal groups in a protected and grazed landscape of the Monte, Argentina
Authors: Miguel Florencia , Cona Mónica I. , Campos Claudia M. 
Published: April 2017

AbstractMammal species contribute in different ways to seed dispersal effectiveness, acting as endozoochorous dispersers, scatter-hoarders and seed predators. Seed removal by these functional mammal groups could be affected by anthropogenic drivers, such as grazing management, a common practice in drylands. We evaluated removal of seeds from a native tree species (Prosopis flexuosa) by terrestrial wildlife mammals with different functional roles, on grazed and ungrazed sites and at different times during the fruiting periodof Prosopis. We offeredProsopisfruits, each containing 15 seeds, to animals and used camera traps to identify the species removing them. We obtained the number of seeds removed (1 fruit removed = 15 seeds removed) by each animal species and each functional group. Native and domestic mammals removed 65.4% of the total seeds offered; 69.5% of offered seeds were removed from the grazed area and 61% from the ungrazed site. Considering removal times, 64.25% of offered seeds were removed during the beginning of the fruiting period ofProsopisand 67% towards the end of this period. Small mammals acting either as seed predators (Graomys griseoflavusandAkodon dolores) or scatter-hoarders (Microcavia australis) were the functional mammal groups removing the highest amount of seeds. Seed predators removed more seeds from the ungrazed site, whereas the scatter-hoarder did so at the grazed site. In the ungrazed area, it would be important to ensure habitat heterogeneity in order to improve seed removal by functional groups that disperse seeds, such as endozoochorous dispersers and scatter-hoarders.
The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA
Authors: Wittmann Sina , Renner Max , Watts Beth R. , Adams Oliver , Huseyin Miles , Baejen Carlo , El Omari Kamel , Kilchert Cornelia , Heo Dong-Hyuk , Kecman Tea , Cramer Patrick , Grimes Jonathan M. , Vasiljeva Lidia 
Published: April 2017

AbstractTermination of RNA polymerase II (Pol II) transcription is an important step in the transcription cycle, which involves the dislodgement of polymerase from DNA, leading to release of a functional transcript. Recent studies have identified the key players required for this process and showed that a common feature of these proteins is a conserved domain that interacts with the phosphorylated C-terminus of Pol II (CTD-interacting domain, CID). However, the mechanism by which transcription termination is achieved is not understood. Using genome-wide methods, here we show that the fission yeast CID-protein Seb1 is essential for termination of protein-coding and non-coding genes through interaction with S2-phosphorylated Pol II and nascent RNA. Furthermore, we present the crystal structures of the Seb1 CTD- and RNA-binding modules. Unexpectedly, the latter reveals an intertwined two-domain arrangement of a canonical RRM and second domain. These results provide important insights into the mechanism underlying eukaryotic transcription termination.
Enabling valley selective exciton scattering in monolayer WSe2 through upconversion
Authors: Manca M. , Glazov M. M. , Robert C. , Cadiz F. , Taniguchi T. , Watanabe K. , Courtade E. , Amand T. , Renucci P. , Marie X. , Wang G. , Urbaszek B. 
Published: April 2017

AbstractExcitons, Coulomb bound electron–hole pairs, are composite bosons and their interactions in traditional semiconductors lead to condensation and light amplification. The much stronger Coulomb interaction in transition metal dichalcogenides such as WSe2 monolayers combined with the presence of the valley degree of freedom is expected to provide new opportunities for controlling excitonic effects. But so far the bosonic character of exciton scattering processes remains largely unexplored in these two-dimensional materials. Here we show that scattering between B-excitons and A-excitons preferably happens within the same valley in momentum space. This leads to power dependent, negative polarization of the hot B-exciton emission. We use a selective upconversion technique for efficient generation of B-excitons in the presence of resonantly excited A-excitons at lower energy; we also observe the excited A-excitons state 2s. Detuning of the continuous wave, low-power laser excitation outside the A-exciton resonance (with a full width at half maximum of 4 meV) results in vanishing upconversion signal.
Wnt signaling in triple-negative breast cancer
Authors: Pohl SÖ-G , Brook N , Agostino M , Arfuso F , Kumar A P , Dharmarajan A 
Published: April 2017

AbstractWnt signaling regulates a variety of cellular processes, including cell fate, differentiation, proliferation and stem cell pluripotency. Aberrant Wnt signaling is a hallmark of many cancers. An aggressive subtype of breast cancer, known as triple-negative breast cancer (TNBC), demonstrates dysregulation in canonical and non-canonical Wnt signaling. In this review, we summarize regulators of canonical and non-canonical Wnt signaling, as well as Wnt signaling dysfunction that mediates the progression of TNBC. We review the complex molecular nature of TNBC and the emerging therapies that are currently under investigation for the treatment of this disease.
Young inversion with multiple linked QTLs under selection in a hybrid zone
Authors: Lee Cheng-Ruei , Wang Baosheng , Mojica Julius P. , Mandáková Terezie , Prasad Kasavajhala V. S. K. , Goicoechea Jose Luis , Perera Nadeesha , Hellsten Uffe , Hundley Hope N. , Johnson Jenifer , Grimwood Jane , Barry Kerrie , Fairclough Stephen , Jenkins Jerry W. , Yu Yeisoo , Kudrna Dave , Zhang Jianwei , Talag Jayson , Golser Wolfgang , Ghattas Kathryn , Schranz M. Eric , Wing Rod , Lysak Martin A. , Schmutz Jeremy , Rokhsar Daniel S. , Mitchell-Olds Thomas 
Published: April 2017

AbstractFixed chromosomal inversions can reduce gene flow and promote speciation in two ways: by suppressing recombination and by carrying locally favoured alleles at multiple loci. However, it is unknown whether favoured mutations slowly accumulate on older inversions or if young inversions spread because they capture pre-existing adaptive quantitative trait loci (QTLs). By genetic mapping, chromosome painting and genome sequencing, we have identified a major inversion controlling ecologically important traits inBoechera stricta. The inversion arose since the last glaciation and subsequently reached local high frequency in a hybrid speciation zone. Furthermore, the inversion shows signs of positive directional selection. To test whether the inversion could have captured existing, linked QTLs, we crossed standard, collinear haplotypes from the hybrid zone and found multiple linked phenology QTLs within the inversion region. These findings provide the first direct evidence that linked, locally adapted QTLs may be captured by young inversions during incipient speciation.
Adaptation to deep-sea chemosynthetic environments as revealed by mussel genomes
Authors: Sun Jin , Zhang Yu , Xu Ting , Zhang Yang , Mu Huawei , Zhang Yanjie , Lan Yi , Fields Christopher J. , Hui Jerome Ho Lam , Zhang Weipeng , Li Runsheng , Nong Wenyan , Cheung Fiona Ka Man , Qiu Jian-Wen , Qian Pei-Yuan 
Published: April 2017

AbstractHydrothermal vents and methane seeps are extreme deep-sea ecosystems that support dense populations of specialized macro­benthos such as mussels. But the lack of genome information hinders the understanding of the adaptation of these animals to such inhospitable environments. Here we report the genomes of a deep-sea vent/seep mussel (Bathymodiolus platifrons) and a shallow-water mussel (Modiolus philippinarum). Phylogenetic analysis shows that these mussel species diverged approximately 110.4 million years ago. Many gene families, especially those for stabilizing protein structures and removing toxic substances from cells, are highly expanded inB. platifrons,indicating adaptation to extreme environmental conditions. The innate immune system ofB. platifronsis considerably more complex than that of other lophotrochozoan species, includingM.philippinarum, with substantial expansion and high expression levels of gene families that are related to immune recognition, endocytosis and caspase-mediated apoptosis in the gill, revealing presumed genetic adaptation of the deep-sea mussel to the presence of its chemoautotrophic endosymbionts. A follow-up metaproteomic analysis of the gill ofB. platifronsshows methanotrophy, assimilatory sulfate reduction and ammonia metabolic pathways in the symbionts, providing energy and nutrients, which allow the host to thrive. Our study of the genomic composition allowing symbiosis in extremophile molluscs gives wider insights into the mechanisms of symbiosis in other organisms such as deep-sea tubeworms and giant clams.
The dual developmental origin of spinal cerebrospinal fluid-contacting neurons gives rise to distinct functional subtypes
Authors: Djenoune Lydia , Desban Laura , Gomez Johanna , Sternberg Jenna R. , Prendergast Andrew , Langui Dominique , Quan Feng B. , Marnas Hugo , Auer Thomas O. , Rio Jean-Paul , Del Bene Filippo , Bardet Pierre-Luc , Wyart Claire 
Published: April 2017

AbstractChemical and mechanical cues from the cerebrospinal fluid (CSF) can affect the development and function of the central nervous system (CNS). How such cues are detected and relayed to the CNS remains elusive. Cerebrospinal fluid-contacting neurons (CSF-cNs) situated at the interface between the CSF and the CNS are ideally located to convey such information to local networks. In the spinal cord, these GABAergic neurons expressing the PKD2L1 channel extend an apical extension into the CSF and an ascending axon in the spinal cord. In zebrafish and mouse spinal CSF-cNs originate from two distinct progenitor domains characterized by distinct cascades of transcription factors. Here we ask whether these neurons with different developmental origins differentiate into cells types with different functional properties. We show in zebrafish larva that the expression of specific markers, the morphology of the apical extension and axonal projections, as well as the neuronal targets contacted by CSF-cN axons, distinguish the two CSF-cN subtypes. Altogether our study demonstrates that the developmental origins of spinal CSF-cNs give rise to two distinct functional populations of sensory neurons. This work opens novel avenues to understand how these subtypes may carry distinct functions related to development of the spinal cord, locomotion and posture.
The TLR2 Binding Neisserial Porin PorB Enhances Antigen Presenting Cell Trafficking and Cross-presentation
Authors: Reiser Michael L. , Mosaheb Munir M. , Lisk Christina , Platt Andrew , Wetzler Lee M. 
Published: April 2017

AbstractTOLL-like receptor (TLR) ligands activate both innate and adaptive immune cells, while modulating the cellular immune response. The outer membrane protein (OMP) fromNeisseria meninigitidis, PorB, is a naturally occurring TLR2 ligand and functions as an adjuvant. Here, we demonstrate that PorB increases the level of OVA in the endo-/lysosomal cellular compartment of BMDCs, increases antigen presenting cell (APC) trafficking to draining lymph nodes, and enhances antigen cross-presentation. PorB is capable of mounting an antigen specific T cell response by efficiently stimulating antigen cross-presentationin vivoandin vitroassessed by BMDC OT-I cocultivation assays. The enhanced antigen cross-presentation and the increased APC recruitment to secondary lymphoid tissues expand the scope of known adjuvant effects of PorB on the immune system. Our findings lead to a better understanding of how TLR-ligand based adjuvants can alter and modulate immune responses.
Contact Angle Measurement of Small Capillary Length Liquid in Super-repelled State
Authors: Liu Tingyi “Leo” , Kim Chang-Jin “CJ” 
Published: April 2017

AbstractThe difficulty of measuring very large contact angles (>150 degrees) has become more relevant with the increased popularity of super-repellent surfaces. Measurement is more difficult for dynamic contact angles, for which theoretical profiles do not fit well, and small capillary length liquids, whose sessile droplets sag by gravity. Here, we expand the issue to the limit by investigating dynamic contact angles of liquids with an extremely small capillary length (<1.0 mm), empowered by the superomniphobic surface that can super-repel even fluorinated solvents, which highly wet all materials. Numerically simulating and experimentally testing 13 different liquids on the superomniphobic surface, we discover their dynamic contact angles can be measured with a consistent accuracy despite their vastly different capillary lengths if one keeps the lens magnification inversely proportional to the capillary length. Verifying the droplet equator height is a key parameter, we propose a new Bond number defined by the equator height and optical resolution to represent the measurement accuracy of large contact angles. Despite negligible improvement for most liquids today, the proposed approach teaches how to measure very large contact angles with consistent accuracy when any of the liquids in consideration has a capillary length below 1.0 mm.