bluuebunny/crossref_metadata_2025_split huggingface dataset:
hp-FEM for the $$\alpha $$-Mosolov problem: a priori and a posteriori error estimates
Authors: Banz Lothar , Stephan Ernst P. 
Published: September 2024

AbstractAn hp-finite element discretization for the $$\alpha $$
α
-Mosolov problem, a scalar variant of the Bingham flow problem but with the $$\alpha $$
α
-Laplacian operator, is being analyzed. Its weak formulation is either a variational inequality of second kind or equivalently a non-smooth but convex minimization problem. For any $$\alpha \in (1,\infty )$$

α
∈
(
1
,
∞
)

we prove convergence, including guaranteed convergence rates in the mesh size h and polynomial degree p of the FE-solution of the corresponding discrete variational inequality. Moreover, we derive two families of reliable a posteriori error estimators which are applicable to any “approximation” of the exact solution and not only to the FE-solution and can therefore be coupled with an iterative solver. We prove that any quasi-minimizer of those families of a posteriori error estimators satisfies an efficiency estimate. All our results contain known results for the Mosolov problem by setting $$\alpha =2$$

α
=
2

. Numerical results underline our theoretical findings.
Zebrafish Models for Skeletal and Extraskeletal Osteogenesis Imperfecta Features: Unveiling Pathophysiology and Paving the Way for Drug Discovery
Authors: Masiero Cecilia , Aresi Carla , Forlino Antonella , Tonelli Francesca 
Published: September 2024

AbstractIn the last decades, the easy genetic manipulation, the external fertilization, the high percentage of homology with human genes and the reduced husbandry costs compared to rodents, made zebrafish a valid model for studying human diseases and for developing new therapeutical strategies. Since zebrafish shares with mammals the same bone cells and ossification types, it became widely used to dissect mechanisms and possible new therapeutic approaches in the field of common and rare bone diseases, such as osteoporosis and osteogenesis imperfecta (OI), respectively. OI is a heritable skeletal disorder caused by defects in gene encoding collagen I or proteins/enzymes necessary for collagen I synthesis and secretion. Nevertheless, OI patients can be also characterized by extraskeletal manifestations such as dentinogenesis imperfecta, muscle weakness, cardiac valve and pulmonary abnormalities and skin laxity. In this review, we provide an overview of the available zebrafish models for both dominant and recessive forms of OI. An updated description of all the main similarities and differences between zebrafish and mammal skeleton, muscle, heart and skin, will be also discussed. Finally, a list of high- and low-throughput techniques available to exploit both larvae and adult OI zebrafish models as unique tools for the discovery of new therapeutic approaches will be presented.
High patient satisfaction with Customized Total Knee Arthroplasty at five year follow-up
Authors: Schippers Philipp , Wunderlich Felix , Afghanyar Yama , Buschmann Victoria , Klonschinski Thomas , Drees Philipp , Eckhard Lukas 
Published: September 2024

Abstract
Purpose
Despite numerous studies demonstrating promising short-term outcomes of Total Knee Arthroplasty (TKA) with Customized Individually Made (CIM) implants, there is a significant lack of data on their mid-term effectiveness. Given the increasing number of TKAs performed annually, the rising demand for CIM implants, and the associated burden of revision surgeries, understanding the mid-term performance of CIM implants is crucial. Therefore, this study aims to report on the mid-term (minimum 5 years) outcomes of TKA using a CIM implant.

Methods
This retrospective cohort study included a consecutive series of 116 patients who received the ConforMIS® iTotal CR implant between 2015 and 2018. Inclusion criteria were end-stage knee osteoarthritis with coronal deformities below 10° and absence of ligamentous instability. Exclusion criteria included simultaneous bilateral TKA. Patients were followed up at a minimum of five years post-surgery. They completed a questionnaire reporting on satisfaction, pain levels using the Visual Analogue Scale (VAS), current weight, the Oxford Knee Score (OKS), and the Forgotten Joint Score for the knee (FJS-knee). Statistical analysis included descriptive statistics for demographic and clinical variables, and outcomes were reported as means with ranges.

Results
The mean follow-up duration was 5.9 ± 0.8 years (range 5–7.4 years). 90% of patients stated they would undergo the same operation again, and 93% were either satisfied or very satisfied. The mean VAS for pain at rest was 2 ± 1.5 (range 0–6) and during exercise was 3 ± 2 (range 0–8). 58 patients (53%) managed to lose weight. The mean OKS was 41 ± 9 points (range 15–48), and the mean FJS-knee was 67 ± 23 points (range 4–100). No severe complications occurred.

Conclusion
CIM TKA using the ConforMIS® iTotal CR implant can achieve excellent results with 93% of patients being satisfied or very satisfied at mid-term follow-up of five years. Prospective, randomized, and patient-blinded trials comparing off-the-shelf (OTS) TKAs with CIM implants are necessary to evaluate whether these implants are superior or not.
Interannual variability in potential impacts of upper ocean salinity on sea surface cooling induced by tropical cyclones in the northwestern Pacific
Authors: Miyagi Rintaro , Tozuka Tomoki 
Published: September 2024

AbstractUsing a new measure that relates tropical cyclone (TC)-induced sea surface cooling with the strength of TCs, interannual variations in potential impacts of the upper ocean stratification on TC-induced sea surface cooling associated with the evolution of El Niño/Southern Oscillation (ENSO) are investigated in the northwestern Pacific using an ocean reanalysis product, with a special focus on haline effects. It is found that the haline stratification could suppress the sea surface cooling by as much as 20% to the south of 20°N in the peak typhoon season (July-October), and this contribution is different between their developing years (September-October) and decaying years (July-August). More specifically, the haline effects may vary up to 25% (40%) during the decaying years of El Niño (La Niña). Due to anomalous haline effects, the region to the west of 160°E is susceptible to the sea surface cooling during the developing and decaying years of El Niño, while the cooling could be suppressed in this region during the decaying years of La Niña. Although the effects of haline stratification have been found less important than those of thermal stratification, potential impacts of the upper ocean salinity on TC-induced sea surface cooling associated with the ENSO have been quantitatively estimated for the first time. Since the main focus of this paper is to present the new measure and discuss potential impacts of the upper ocean salinity stratification, further verifications need to be conducted once more observational data is accumulated or through numerical simulations.
Environmental study and stress-related biomarkers modifications in a crew during analog astronaut mission EMMPOL 6
Authors: Giacon T. A. , Mrakic-Sposta Simona , Bosco G. , Vezzoli A. , Dellanoce Cinzia , Campisi M. , Narici M. , Paganini M. , Foing B. , Kołodziejczyk A. , Martinelli M. , Pavanello S. 
Published: September 2024

Abstract

Purpose
Human presence in space is increasingly frequent, but we must not forget that it is a hostile environment. We aimed to study the characteristics of experimental scenarios, to obtain data on human response to isolation, disruption of circadian rhythm and high levels of psychophysical stress.

Methods
In these experiments, we evaluated stress response in five young healthy subjects inside an earth-based moon-settlement-like habitat during a 1-week long analog astronaut mission. Wearable devices were used to monitor daily step count of the subjects, physical activity, heart rate during physical exercise and at rest, and sleep parameters. From saliva and urine samples collected every day at awakening, we studied oxy-inflammation biomarkers and hormones (stress and appetite) were studied too.

Results
At the end of the week, all subjects revealed an increase in oxidative stress and cortisol levels but no inflammation biomarkers variations, in conjunction with increasing time/daily exercise. Furthermore, a significant decrease in hours of sleep/day, sleep quality, and REM phase of sleep was recorded and correlated with the increase of reactive oxygen species.

Conclusion
Oxidative stress increased in a short period of time and may be attributed to the influence of psychological stress during confinement, as well as increased exercise and decreased amount of sleep. On a long-term basis, this could impact performance.
Biliary drainage in patients with malignant distal biliary obstruction: results of an Italian consensus conference
Authors: Marzioni Marco , Crinò Stefano Francesco , Lisotti Andrea , Fuccio Lorenzo , Vanella Giuseppe , Amato Arnaldo , Bertani Helga , Binda Cecilia , Coluccio Chiara , Forti Edoardo , Fugazza Alessandro , Ligresti Dario , Maida Marcello , Marchegiani Giovanni , Mauro Aurelio , Mirante Vincenzo Giorgio , Ricci Claudio , Rizzo Giacomo Emanuele Maria , Scimeca Daniela , Spadaccini Marco , Arvanitakis Marianna , Anderloni Andrea , Fabbri Carlo , Tarantino Ilaria , Arcidiacono Paolo Giorgio ,   i-EUS Group
Published: September 2024

Abstract
Background
Malignant Distal Biliary Obstruction (MBDO) is a common event occurring along the natural history of both pancreatic cancer and cholangiocarcinoma. Epidemiological and biological features make MBDO one of the key elements of the clinical management of patients suffering for of pancreatic cancer or cholangiocarcinoma. The development of dedicated biliary lumen-apposing metal stents (LAMS) is changing the clinical work up of patients with MBDO. i-EUS is an Italian network of clinicians and scientists with a special interest in biliopancreatic endoscopy, EUS in particular.

Methods
The scientific methodology was chosen in line with international guidance and in a fashion similar to those applied by broader scientific associations. PICO questions were elaborated and subsequently voted by a broad panel of experts within a simplified Delphi process.

Results and conclusions
The manuscripts describes the results of a consensus conference organized by i-EUS with the aim of providing an evidence based-guidance for the appropriate use of the techniques in patients with MBDO.
Taste alterations after hematopoietic cell transplantation: a scoping review
Authors: Dequae Caroline G. R. , Raber-Durlacher Judith E. , Epstein Joel B. , de Vries Ralph , Laheij Alexa M. G. A. 
Published: September 2024

Abstract
Purpose
This review aimed to evaluate the prevalence and characteristics of dysgeusia after hematopoietic cell transplantation (HCT).

Methods
A literature search (in PubMed, Embase.com and Web of Science) for clinical studies evaluating taste before and after HCT was performed up to June 22, 2023, in collaboration with a medical information specialist. After title and abstract review (N = 807) followed by full-text review (N = 61), articles that met the inclusion criteria were summarized in a table and synthesized narratively.

Results
11 articles were analyzed in this review. All studies had a prospective design and patient populations included children (N = 3) and adults (N = 8) undergoing allogeneic or autologous HCT. Taste was assessed objectively (N = 6) and/or subjectively (N = 8) between baseline and 12 months after HCT. Before HCT, the self-reported (0–31%) and objective (2.4–10%) prevalence of dysgeusia was low. During the neutropenic phase, self-reported (20–100%) and objective (21.4%) dysgeusia was highest. In the post-engraftment period, the self-reported (18%) and objective (0–33%) prevalence of dysgeusia decreased. Different taste qualities were assessed in six studies including salt, sour, bitter, sweet, and umami.

Conclusions
Some patients undergoing HCT experience dysgeusia prior to treatment. During the neutropenic phase, they had highest complaints, with recovery occurring in the post-engraftment period. All basic tastes, except bitter, were affected. Umami and salt were most affected during treatment. These findings have implications for patient management.
Fracturing Processes in Specimens with Internal vs. Throughgoing Flaws: An Experimental Study Using 3D Printed Materials
Authors: Almubarak Majed , Germaine John T. , Einstein Herbert H. 
Published: September 2024

AbstractThe fracturing behavior and associated mechanical characterization of rocks are important for many applications in the fields of civil, mining, geothermal, and petroleum engineering. Laboratory testing of rocks plays a major role in understanding the underlying processes that occur on the larger scale and for predicting rock behavior. Fracturing research requires well-defined and consistent boundary conditions. Consequently, the testing design and setup can greatly influence the results. In this study, a comprehensive experimental program using an artificial material was carried out to systematically evaluate the effects of different parameters in rock testing under uniaxial compression. The parameters include compression platen type, specimen centering, loading control method, boundary constraints, and flaw parameters. The results show that these testing conditions have a significant effect on the mechanical behavior of rocks. Using a fixed compression platen helped reduce bulging of the material. Centering of the specimen played a critical role to avoid buckling and unequal distribution of stress. Slower displacement rates can control the energy being released once failure occurs to prevent the specimen from exploding. Also, the frictional end effects were investigated by comparing friction-reduced and non-friction-reduced end conditions. Very importantly, the study also identified variations in crack initiation and propagation between specimens with internal flaws and specimens with throughgoing flaws. This investigation showed that wing cracks appeared in specimens with throughgoing flaws, while wing cracks with petal cracks were associated with the internal flaws. It also showed that the mechanical properties are influenced by the inclination of the flaws and established that specimens with internal flaws generally exhibit higher strength compared to specimens with throughgoing flaws. The systematic analysis presented in this work sheds light on important considerations that need to be taken into account when conducting fracture research and adds knowledge to the fundamental understanding of how fractures occur in nature.
High-quality reference plastomes in Tillandsia species living at the dry limits
Authors: Kiefer Christiane , Buchmann David , Koch Marcus A. 
Published: September 2024

AbstractOngoing climate change has had severe impacts on biota worldwide, including plants and especially those with narrow ecological niches that have adapted to extreme environments for several hundred thousand of years. Several members of the genus Tillandsia are known for their ability to live at the dry limits of life in the Atacama Desert and have potential as bioindicators for climate change at the Pacific Ocean and adjacent ecosystems. However, genomic information on these plants is scarce. In this study, five complete plastid genomes of two Tillandsia species were de novo assembled at very high quality using DNA sequence data from a combination of next-generation short-read and Sanger sequencing. The newly assembled and fully annotated plastid genomes had an average length of 156,319 base-pairs with the typical highly conserved quadripartite circular structures. Gene order and content were highly conserved, with the exception of the variable gene ycf1. The newly assembled plastid genomes were placed into a broader phylogenetic context to check the quality of sequence data obtained from past approaches relying on reference-based assemblies. It is shown that earlier presented Tillandsia plastomes are either not of sufficient quality or lack any metadata. The herein presented reference plastomes will guide future research to study parallel and convergent evolution in a reliable evolutionary framework and will allow the use of plastome data with little genetic variation for population genomics studies in species such as Tillandisa landbeckii with prevailing clonal propagation.
Interactive abstract interpretation: reanalyzing multithreaded C programs for cheap
Authors: Erhard Julian , Saan Simmo , Tilscher Sarah , Schwarz Michael , Holter Karoliine , Vojdani Vesal , Seidl Helmut 
Published: September 2024

Abstract
To put sound program analysis at the fingertips of the software developer, we propose a framework for interactive abstract interpretation of multithreaded C code. Abstract interpretation provides sound analysis results, but can be quite costly in general. To achieve quick response times, we incrementalize the analysis infrastructure, including postprocessing, without necessitating any modifications to the analysis specifications themselves. We rely on the local generic fixpoint engine TD – which we enhance with reluctant destabilization to minimize reanalysis effort. Dedicated further improvements support precise incremental analysis of program properties that include concurrency deficiencies such as data-races. The framework has been implemented in the static analyzer Goblint, and combined with the MagpieBridge framework to relay findings to IDEs. We evaluate our implementation w.r.t. the yard sticks of response time and consistency. We also provide examples of program development highlighting the usability of our approach.
The shift–rotation absolute testing method based on autocollimation
Authors: Li Jianke , Wu Yongqian , Liu Fengwei , Tang Zhan , Quan Haiyang , Chen Xiaojun 
Published: September 2024

AbstractThe shift–rotation method is an absolute testing method that has attracted much attention in recent years, and detection accuracy at the subnanometer level has been achieved. However, for flat absolute calibration, the power aberration cannot be calibrated via the traditional shift–rotation absolute testing method. To solve this problem, we propose a shift–rotation absolute testing method based on autocollimation, which detects the tilt error of the tested mirror caused by the external environment and guides the adjustment of the stage to remove it. Simulations and experiments are conducted to prove this theory. A comparison with liquid experiments shows that the autocollimated shift–rotation method can achieve accurate absolute power aberration and can compensate for the shortcomings of the traditional shift–rotation method.
Multiscale computational analysis of the steady fluid flow through a lymph node
Authors: Girelli Alberto , Giantesio Giulia , Musesti Alessandro , Penta Raimondo 
Published: September 2024

AbstractLymph Nodes (LNs) are crucial to the immune and lymphatic systems, filtering harmful substances and regulating lymph transport. LNs consist of a lymphoid compartment (LC) that forms a porous bulk region, and a subcapsular sinus (SCS), which is a free-fluid region. Mathematical and mechanical challenges arise in understanding lymph flow dynamics. The highly vascularized lymph node connects the lymphatic and blood systems, emphasizing its essential role in maintaining the fluid balance in the body. In this work, we describe a mathematical model in a steady setting to describe the lymph transport in a lymph node. We couple the fluid flow in the SCS governed by an incompressible Stokes equation with the fluid flow in LC, described by a model obtained by means of asymptotic homogenisation technique, taking into account the multiscale nature of the node and the fluid exchange with the blood vessels inside it. We solve this model using numerical simulations and we analyze the lymph transport inside the node to elucidate its regulatory mechanisms and significance. Our results highlight the crucial role of the microstructure of the lymph node in regularising its fluid balance. These results can pave the way to a better understanding of the mechanisms underlying the lymph node’s multiscale functionalities which can be significantly affected by specific physiological and pathological conditions, such as those characterising malignant tissues.
A Large Language Model to Detect Negated Expressions in Radiology Reports
Authors: Su Yvonne , Babore Yonatan B. , Kahn Charles E. 
Published: September 2024

AbstractNatural language processing (NLP) is crucial to extract information accurately from unstructured text to provide insights for clinical decision-making, quality improvement, and medical research. This study compared the performance of a rule-based NLP system and a medical-domain transformer-based model to detect negated concepts in radiology reports. Using a corpus of 984 de-identified radiology reports from a large U.S.-based academic health system (1000 consecutive reports, excluding 16 duplicates), the investigators compared the rule-based medspaCy system and the Clinical Assertion and Negation Classification Bidirectional Encoder Representations from Transformers (CAN-BERT) system to detect negated expressions of terms from RadLex, the Unified Medical Language System Metathesaurus, and the Radiology Gamuts Ontology. Power analysis determined a sample size of 382 terms to achieve α = 0.05 and β = 0.8 for McNemar’s test; based on an estimate of 15% negated terms, 2800 randomly selected terms were annotated manually as negated or not negated. Precision, recall, and F1 of the two models were compared using McNemar’s test. Of the 2800 terms, 387 (13.8%) were negated. For negation detection, medspaCy attained a recall of 0.795, precision of 0.356, and F1 of 0.492. CAN-BERT achieved a recall of 0.785, precision of 0.768, and F1 of 0.777. Although recall was not significantly different, CAN-BERT had significantly better precision (χ2 = 304.64; p < 0.001). The transformer-based CAN-BERT model detected negated terms in radiology reports with high precision and recall; its precision significantly exceeded that of the rule-based medspaCy system. Use of this system will improve data extraction from textual reports to support information retrieval, AI model training, and discovery of causal relationships.
Optimizing the economic dispatch of weakly-connected mini-grids under uncertainty using joint chance constraints
Authors: Ouanes Nesrine , Grandón Tatiana González , Heitsch Holger , Henrion René 
Published: September 2024

AbstractIn this paper, we deal with a renewable-powered mini-grid, connected to an unreliable main grid, in a Joint Chance Constrained (JCC) programming setting. In several rural areas in Africa with low energy access rates, grid-connected mini-grid system operators contend with four different types of uncertainties: forecasting errors of solar power and load; frequency and outages duration from the main-grid. These uncertainties pose new challenges to the classical power system’s operation tasks. Three alternatives to the JCC problem are presented. In particular, we present an Individual Chance Constraint (ICC), Expected-Value Model (EVM) and a so called regular model that ignores outages and forecasting uncertainties. The JCC model has the capability to guarantee a high probability of meeting the local demand throughout an outage event by keeping appropriate reserves for Diesel generation and battery discharge. In contrast, the easier to handle ICC model guarantees such probability only individually for different time steps, resulting in a much less robust dispatch. The even simpler EVM focuses solely on average values of random variables. We illustrate the four models through a comparison of outcomes attained from a real mini-grid in Lake Victoria, Tanzania. The results show the dispatch modifications for battery and Diesel reserve planning, with the JCC model providing the most robust results, albeit with a small increase in costs.