bluuebunny/crossref_metadata_2025_split huggingface dataset:
Expanding horizons: lung transplantation for non-IPF interstitial lung diseases
Authors: Citak Sevinc , Saribas Ertan , Halis Ayse Nigar , Alkilic Fatma Feyza , Cardak Murat Ersin , Vayvada Mustafa , Tasci Ahmet Erdal 
Published: October 2024

Abstract
Objective
Interstitial lung diseases (ILDs) are diverse pulmonary disorders marked by diffuse lung inflammation and fibrosis. The variability in characteristics and treatment approaches complicates diagnosis and management. In advanced cases requiring transplantation, determining indications and selecting suitable candidates presents additional challenges.

Methods
Of all patients with non-IPF ILD between December 2016 to December 2022 were analyzed retrospectively. Patients were categorized into two groups: transplanted patients and deceased patients on the waiting list. Clinical data and survival outcomes were compared between groups.

Results
Of the 43 patients, 20 underwent lung transplantation while 23 died awaiting transplantation. Waiting list mortality was 53.4%, with median waiting times similar between groups (3 months for transplant patients and 6 months for those on the waiting list). There were no significant differences between groups in age, gender, height, BMI, 6-minute walk test (6MWT), or forced vital capacity (FVC). The prevalence of pulmonary hypertension (PH) was 76.7% in right heart catheterizations, similar in both groups. One single and 19 bilateral lung transplants were performed. Overall, 13 of the 20 patients survived to discharge from the hospital. One-year mortality was 7/20 (35%). The median follow-up was 34 months, with a 1-year conditional survival of 90.9% at 3 years and 70.7% at 5 years.

Conclusions
This study underscores the importance of further research into non-IPF ILDs. Lung transplantation remains a viable option that can significantly enhance both the quality and longevity of life for patients with advanced ILD.
Marketing mental health services: a mixed-methods analysis of racially and ethnically diverse college students’ engagement with and perspectives on U.S. university mental health clinics’ websites
Authors: Aguilar Silvan Yesenia , Hamza Sarah , Fardeheb Sara , Bird Christine , Ng Lauren C. 
Published: October 2024

Abstract
Background
The United States (U.S.) faces a significant mental health crisis, with around 52.9 million adults experiencing mental health disorders, with young adults (18–25 years old), such as college students, having the highest prevalence and lowest service utilization rates. While efforts to expand mental health services through “push” strategies are in place (e.g., training therapists in evidence-based therapies), limited initial engagement suggests a need for “pull strategies” and targeted marketing that make services attractive to college students and increase demand. This mixed-methods study identifies U.S. university mental health clinic websites and website characteristics that are attractive and engaging to college students interested in seeking mental health services (i.e., students were considering or actively looking for mental health support).

Methods
Eleven U.S. university websites were chosen (10 randomly and one from the university where students were attending) from a pool of 44 Psychological Clinical Science Accreditation System training clinics websites. Fifty-seven college students (Mage = 20.95, SD = 2.97; 81% female; 68% racial/ethnic minority) were videorecorded engaging with two U.S. university mental health clinic websites, completed self-report engagement measures, and gave detailed feedback about websites through semi-structured interviews.

Results
Likert scale scores revealed moderate engagement with all websites (e.g., they were interesting and helpful). Qualitative results indicated that websites that provided important and easily understood information about key features of services (e.g., types, evidence-base, and cost), therapist backgrounds, psychoeducation, used lay language, and had an appealing website layout (e.g., color, font, images, organization, and interactive components) generated greater consumer interest and trust in their mental health services.

Conclusions
This study emphasizes the importance of using marketing strategies to enhance college students’ engagement through mental health service websites. Salient features, psychoeducation, and effective promotional strategies (e.g., how information is presented) were identified as crucial for website engagement and subsequent mental health service uptake. Using marketing strategies, such as tailoring language to consumer literacy levels, describing the evidence-base of services, and improving website design may address college students’ needs and enhance initial mental health service engagement.
Ionizing radiation effects on blood-derived extracellular vesicles: insights into miR-34a-5p-mediated cellular responses and biomarker potential
Authors: Huber Chiara , Elsaeed Omar , Lahmer Pia , Moertl Simone 
Published: October 2024

AbstractAdverse effects of ionizing radiation on normal tissues limit the radiation dose in cancer treatment, thereby compromising treatment efficiency. Among the consistently affected non-cancer cells, peripheral blood mononuclear cells (PBMCs) exhibit high radiosensitivity and have the potential to induce systemic effects. PBMC-released extracellular vesicles (EVs), contribute to the communication of such systemic effects. This study aimed to investigate the effects of ionizing radiation on EVs as part of the systemic response of PBMCs in terms of microRNA cargo and biological functions.Therefore, whole blood samples from healthy donors were irradiated ex-vivo (0 Gy, 1 Gy, 2 Gy, 4 Gy) and EVs from PBMCs were isolated after 96 h by PEG precipitation or ultracentrifugation. Candidate microRNAs were examined in PBMC-derived EVs from individual donors. The uptake of membrane-stained fluorescent EVs by different recipient cells was quantified by fluorescence-activated cell sorting analysis. The biological effects of increased miR-34a-5p and of total EVs on recipient cells were assessed.Irradiation of PBMCs induced a dose-dependent upregulation of miR-34a-5p within EVs and PBMCs. However, interindividual differences between donors were noticed in the extent of upregulation, and small EVs displayed more pronounced changes in microRNA levels in comparison to large EVs. Irradiation in presence of the small molecule inhibitor KU-60019 demonstrated that this upregulation is dependent on ATM (Ataxia telangiectasia mutated) activation. Moreover, fibroblasts and keratinocytes were identified as preferred EV recipients. Increased miR-34a-5p levels led to a significant reduction in viability and induction of senescence in keratinocytes but not in fibroblasts, indicating a cell type-specific response.In conclusion, this study further elucidated the complex cellular response of normal tissue after radiation exposure. It confirmed radiation-induced modifications of microRNA expression levels in EVs from PBMCs and identified a robust upregulation of miR-34a-5p in the small EV subfraction, suggesting this microRNA as a potential novel candidate for the development of biomarkers for radiation exposure. Moreover, the different uptake efficiencies observed among specific cell types suggested that EVs induce cell type-specific responses in the intercellular communication of systemic radiation effects.
Impact of a short-term pharmacy study abroad Program: student outcomes and program evaluation
Authors: Elmokadem Eman Mohamed , Mahmoud Azza A. , Bennett-Lenane Harriet , Murphy Kevin D. , Khalil Noha 
Published: October 2024

Abstract
Objective
This study examined the impact of a short-term study abroad program, focusing on program evaluation, attendee satisfaction, and acquired knowledge and skills. A questionnaire survey was conducted covering various aspects including demographics, program evaluation, and feedback.

Results
Results indicated higher female participation due to gender imbalances in pharmacy students in Egypt, with senior students recognizing the value of international experience. Attendee satisfaction was high, with positive feedback on accommodation, tours, and workshop materials. Field visits and workshops provided valuable experiential learning, with attendees suggesting extending the program’s duration. The program equipped attendees with knowledge and skills relevant to pharmaceutical products and services, leading to improved competences and perceptions. The study concludes that such study abroad experiences profoundly impact personal growth and recommends integrating them into educational curricula for valuable experiences.
The feasibility and acceptability of using EMA and physiological data to measure day-to-day occupational stress, musculoskeletal pain and mental health
Authors: Weale Victoria , Love Jasmine , Clays Els , Oakman Jodi 
Published: October 2024

Abstract
Objectives
This study aimed to assess the feasibility and acceptability of using EMA questionnaires and physiological data via wristbands to measure day-to-day occupational stress, musculoskeletal pain, and mental health among university employees (N = 23), across 10 work days. Adherence to the study protocol as well as participant experiences (via semi-structured interviews) with the protocol were used to assess feasibility and acceptability of the method.

Results
Adherence to the study protocol was excellent. Participants wore the wristband for a mean of 9.7 days. Participants completed a mean of 24.5 EMAs (out of 30). Semi-structured interviews with participants revealed that a small number of participants had difficulties uploading data from the wristband. The timing of EMAs was challenging for some participants, resulting in missed EMAs, raising questions about whether EMA frequency and timing could be changed to improve adherence. Some EMA items were difficult to answer due to the nature of participants’ roles and the work undertaken. Overall, the protocol was feasible and acceptable but highlighted future potential changes including using a different physiological data collection tool, reducing the number of EMAs, adjusting EMA timings, and reviewing EMA items.
Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities
Authors: Yu Yuan , Lin Kaixuan , Wu Haoyu , Hu Mingli , Yang Xuejie , Wang Jie , Grillari Johannes , Chen Jiekai 
Published: October 2024

AbstractThe COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening complications. Exploring the key factors associated with clinical severity highlights that key characteristics of aging, such as cellular senescence, immune dysregulation, metabolic alterations, and impaired regenerative potential, contribute to disruption of tissue homeostasis of the lung and worse clinical outcome. Senolytic and senomorphic drugs, which are anti-aging treatments designed to eliminate senescent cells or decrease the associated phenotypes, have shown promise in alleviating age-related dysfunctions and offer a novel approach to treating diseases that share certain aspects of underlying mechanisms with aging, including COVID-19. This review summarizes the current understanding of aging in COVID-19 progression, and highlights recent findings on anti-aging drugs that could be repurposed for COVID-19 treatment to complement existing therapies.
Development of Bacillus stratosphericus Lysate Concentrate to Control Sebum Secretion through In vitro Studies and Clinical Trial
Authors: Ki Hosam , Yoon Sung Geon , Han Jeung Hi , Shin Byeongmin , Kim Young Soo , Choi Yang Gyu , Hwang Kwang Yeon 
Published: October 2024

AbstractThe sebum on human skin is generated for various causes. The composition of the formed sebum increases the proliferation of Cutibacterium acnes (C. acnes) residing on the skin. As C. acnes proliferates, it produces skin irritants that stimulate the sebaceous glands, increasing sebum production. Skin troubles such as acne may occur. The lysate concentrates of Bacillus stratosphericus (B. stratosphericus), first discovered in the stratosphere, confirmed a 66.35% inhibition of Nitric Oxide (NO) production at 0.50 mg/ml concentration in vitro. Additionally, the growth inhibition efficacy of B. stratosphericus lysate concentrate (BSLC) against C. acnes was confirmed, showing a 95.1% inhibition of growth proliferation at a consistency of 0.50 mg/ml. Based on the in vitro results, the efficacy of BSLC in degrading and reducing sebum was confirmed by reacting it with artificial sebum to various concentrations. The results showed a concentration-dependent decrease in artificial sebum ccording to the efficacy results confirmed in vitro, a clinical trial was conducted to evaluate the daily sebum reduction efficacy of a serum formulation containing 50 mg/ml of BSLC. After a 4-week application, the test group containing BSLC determined a significant 28.68% reduction in sebum levels, demonstrating the practical implications of the research. In conclusion, BSLC is considered to have sufficient industrial value as a valuable ingredient for the cosmetics industry aimed at sebum improvement.
Evaluation of ten plant-derived biocides for the inhibition of photosynthetic organisms on the karst surfaces of heritage buildings
Authors: Long Mingzhong , Xiong Kangning , Lin Jiayu , Tang Boyan , Ao Ziqiang , Chen Yingqiu , Xu Zhiyi 
Published: October 2024

Abstract
Biodeterioration is a significant problem in the conservation of stone heritage buildings. In this study, 10 plant essential oils were assessed for their effectiveness in biofilm inhibition on stone heritage building surfaces under laboratory and in situ conditions, and were compared with traditional biocides such as benzalkonium chloride. The plant extracts were tested against algae and mosses. The effect on algae removal was evaluated by measuring the color of the surface before treatment, after 24 h and after 1 month of treatment. The effect on mosses was assessed by measuring the photosynthetic pigment content of mosses after 24 h of treatment. The results showed that the different plant extracts exhibited different levels of antibiotic activity. Benzalkonium chloride, S. aromaticum and C. cassia extracts showed strong antibiotic activity against all algae and mosses tested. T. mongolicus extracts showed antibiotic activity against only some of the algae and mosses, while the application of P. cablin extracts increased chlorophyll b content in the mosses. The other plant extracts were less effective at inhibiting the growth of algae and mosses. GC–MS compositional analysis further indicated that the higher antibiotic activity of S. aromaticum and C. cassia extracts was related to the high content of eugenol and cinnamaldehyde.
Dietary partitioning in sympatric Paradoxurinae civets in Borneo suggested by compound-specific nitrogen isotope analysis of amino acids
Authors: Nakabayashi Miyabi , Tsutaya Takumi , Ahmad Abdul Hamid , Sasaki Yoko , Ogawa Nanako O. , Ishikawa Naoto F. , Ohkouchi Naohiko 
Published: October 2024

AbstractWe applied stable carbon and nitrogen isotopic analyses to understand the faunivory of the four sympatric wild Paradoxurinae civet species in Borneo, which share similar ecological characteristics. We also employed compound-specific nitrogen isotope analysis of amino acids to estimate these species’ trophic positions (TPs). The bulk stable isotope analysis revealed distinctly lower nitrogen isotope ratios in binturongs than in the other three species. This suggests that binturongs exhibit the lowest degree of faunivory among the four species. Binturongs had the lowest TP estimated from the nitrogen isotope ratios of amino acids (2.0–2.1), followed by small-toothed palm civets (2.4–2.5), masked palm civets (2.7), and common palm civets (2.9). These results suggest that there is little faunivory in binturong and variations in faunivory in the other species. Although the number of samples measured for the nitrogen isotope ratios of amino acids is small (n = 2 for each species), our results suggest that the varying degree of consumption of animal food sources, such as insects, is the key mechanism of niche partitioning in these four Paradoxurinae civet species in Borneo. Such subtle but essential differences in closely related sympatric species would maintain high biodiversity in tropical regions.
Usefulness of driver’s eye movement measurement to detect potential risks under combined conditions of taking second-generation antihistamines and calling tasks
Authors: Sagara Atsunobu , Nagahama Akihito , Aki Hayato , Yoshimura Hiroki , Hiraide Makoto , Shimizu Takatsune , Sano Motohiko , Yumoto Tetsuro , Hosoe Tomoo , Tanaka Kenji 
Published: October 2024

Abstract
Background
Concerns persist regarding the potential reduction in driving performance due to taking second-generation antihistamines or performing hands-free calling. Previous studies have indicated a potential risk to driving performance under an emergency event when these two factors are combined, whereas a non-emergency event was operated effectively. Currently, there is a lack of a discriminative index capable of detecting the potential risks of driving performance impairment. This study aims to investigate the relationship between driving performance and eye movements under combined conditions of taking second-generation antihistamines and a calling task, and to assess the usefulness of eye movement measurements as a discriminative index for detecting potential risks of driving performance impairment.

Methods
Participants engaged in a simulated driving task, which included a calling task, both under taking or not taking second-generation antihistamines. Driving performance and eye movements were monitored during both emergency and non-emergency events, assessing their correlation between driving performance and eye movements. The study further evaluated the usefulness of eye movement as a discriminative index for potential driving impairment risk through receiver operating characteristic (ROC) analysis.

Results
In the case of a non-emergency event, no correlation was observed between driving performance and eye movement under the combined conditions. Conversely, a correlation was observed during an emergency event. The ROC analysis, conducted to assess the discriminative index capability of eye movements in detecting the potential risk of driving performance impairment, demonstrated a high discriminative power, with an area under the curve of 0.833.

Conclusions
The findings of this study show the correlation between driving performance and eye movements under the concurrent influence of second-generation antihistamines and a calling task, suggesting the usefulness of eye movement measurement as a discriminant index for detecting potential risks of driving performance impairment.
Promoting gender equality through localized development strategies: leveraging identification
Authors: Wolff Gaélane 
Published: October 2024

Abstract
The humanitarian discourse has recently shifted towards bolstering the intervention capacities of affected countries and communities through “localization.” However, the implementation of this approach has encountered challenges and disappointments, partly due to conventional short-term interventions driven by external organizations rather than beneficiaries. Empowering women in developing nations is vital for gender equality and women’s rights, given the barriers they face such as unequal access to resources and underrepresentation in governance. Malawi”s context, marked by poverty, limited access to education and healthcare, and cultural norms posing barriers to gender equity, complicates efforts to address inequalities against women. This article explores how localization, particularly through local NGOs, can advance women’s rights in Malawi by challenging gender norms. While recognizing its potential, caution is advised to avoid reinforcing past exclusions. This research investigates how aid localization, leveraging identification, affects gender equality and women’s rights in disaster management and humanitarian efforts. Through field research in Malawi, including 33 interviews with NGO members and beneficiaries, it underscores the role of localization in promoting gender equality and women’s rights, advocating for a more equitable and locally responsive approach to humanitarian action.
GAPS: GPU-accelerated processing service for SM9
Authors: Xu Wenhan , Ma Hui , Zhang Rui 
Published: October 2024

AbstractSM9 was established in 2016 as a Chinese official identity-based cryptographic (IBC) standard, and became an ISO standard in 2021. It is well-known that IBC is suitable for Internet of Things (IoT) applications, since a centralized processing of client data (e.g. IoT cloud) is often done by gateways. However, due to limited computation resources inside IoT devices, the performance of SM9 becomes a bottleneck in practical usage. The existing SM9 implementations are often CPU-based, with relatively low latency and low throughput. Consequently, a pivotal challenge for SM9 in large-scale applications is how to reduce the latency while maximizing throughput for numerous concurrent inputs. After a systematic analysis of the SM9 algorithms, we apply optimization techniques including precomputation, resource caching and parallelization to reduce the overhead of SM9. In this work, we introduce the first practical implementation of SM9 and its underlying curve on GPU. Our GPU implementation combines multiple algorithms and low-level optimizations tailored for GPU’s single instruction, multiple threads architecture in order to achieve high throughput for SM9. Based on these, we propose , a high-performance Cryptography as a Service (CaaS) for SM9. adopts a heterogeneous computing architecture that flexibly schedules the inputs across two implementation platforms: a CPU for the low-latency processing of sporadic inputs, and a GPU for the high-throughput processing of batch inputs. According to our benchmark, only takes a few milliseconds to process a single SM9 request in idle mode. Moreover, when operating in its batch processing mode, can generate 2,038,071 private keys, 248,239 signatures or 238,001 ciphertexts per second. The results show that scales seamlessly across inputs of different sizes, preliminarily demonstrating the efficacy of our solution.
Osteoporosis in the setting of knee arthroplasty: a narrative review
Authors: Daher Mohammad , Mekhael Elio , El-Othmani Mouhanad M. 
Published: October 2024

AbstractPatients undergoing knee replacement, which is mainly indicated in severe osteoarthritis, are frequently co-affected by osteoporosis and osteopenia. With a prevalence standing at around 20% in patients receiving knee arthroplasty, osteoporosis could lead to poor outcomes postoperatively. Some of these complications include periprosthetic fractures and an increased revision rate. Antiresorptive medications have been shown to be beneficial postoperatively. However, no studies have been conducted on whether they had any benefits if given preoperatively. Surgical management may also be beneficial, but this area remains full of controversy.