bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2
Authors: Niu Yuchun , Ma Feng , Huang Weimei , Fang Shun , Li Man , Wei Ting , Guo Linlang 
Published: January 2017

Abstract
Background
Taurine upregulated gene1 (TUG1) as a 7.1-kb lncRNA, has been shown to play an oncogenic role in various cancers. However, the biological functions of lncRNA TUG1 in small cell lung cancer (SCLC) remain unknown. The aim of this study is to explore the roles of TUG1 in cell growth and chemoresistance of SCLC and its possible molecular mechanism.

Methods
The expression of TUG1 in thirty-three cases of SCLC tissues and SCLC cell line were examined by quantitative RT-PCR (qRT-PCR). The functional roles of TUG1 in SCLC were demonstrated by CCK8 assay, colony formation assay, wound healing assay and transwell assay, flow cytometry analysis and in vivo study through siRNA or shRNA mediated knockdown. Western blot assays were used to evaluate gene and protein expression in cell lines. Chromatin immunoprecipitation (ChIP) and RNA binding protein immunoprecipitation (RIP) were performed to confirm the molecular mechanism of TUG1 involved in cell growth and chemoresistance of small cell lung cancer.

Results
We found that TUG1 was overexpressed in SCLC tissues, and its expression was correlated with the clinical stage and the shorter survival time of SCLC patients. Moreover, downregulation of TUG1 expression could impair cell proliferation and increased cell sensitivity to anticancer drugs both in vitro and in vivo. We also discovered that TUG1 knockdown significantly promoted cell apoptosis and cell cycle arrest, and inhibited cell migration and invasion in vitro . We further demonstrated that TUG1 can regulate the expression of LIMK2b (a splice variant of LIM-kinase 2) via binding with enhancer of zeste homolog 2 (EZH2), and then promoted cell growth and chemoresistance of SCLC.

Conclusions
Together, these results suggested that TUG1 mediates cell growth and chemoresistance of SCLC by regulating LIMK2b via EZH2.
Activity-based Twitter sampling for content-based and user-centric prediction models
Authors: Aghababaei Somayyeh , Makrehchi Masoud 
Published: January 2017

AbstractIncreasingly more applications rely on crowd-sourced data from social media. Some of these applications are concerned with real-time data streams, while others are more focused on acquiring temporal footprints from historical data. Nevertheless, determining the subset of “credible” users is crucial. While the majority of sampling approaches focus on individual static networks, dynamic user activity over time is usually not considered, which may result in activity gaps in the collected data. Models based on noisy and missing data can significantly degrade in performance. In this study, we demonstrate how to sample Twitter users in order to produce more credible data for temporal prediction models. We present an activity-based sampling approach where users are selected based on their historical activities in Twitter. The predictability of the collected content from activity-based and random sampling is compared in a content-based and user-centric temporal model. The results indicate the importance of an activity-oriented sampling method for the acquisition of more credible content for temporal models.
The Diagnosis of Acute Pulmonary Embolism
Authors: Islam Ebtesam , Test Victor J. 
Published: January 2017

This paper reviews the most current literature on the diagnosis of pulmonary thromboembolism. The epidemiology and symptomology of this disorder, including common symptoms such as fever, chest pain, dyspnea, edema, and syncope, are reviewed. The utility of basic and easily available testing, such as electrocardiography and chest radiography, is evaluated. The literature on determining the pretest probability of venous thromboembolism with scoring systems, such as the Wells Score, the Geneva Scoring System, and the Pulmonary Embolism Rule Out Criteria, is appraised. As the evaluation of pulmonary embolism has evolved, multiple imaging techniques has been developed and studied. Ultrasonography, computed tomography with angiography, magnetic resonance angiography, ventilation perfusion lung scanning, and SPECT ventilation-perfusion lung imaging are discussed. In conclusion, the diagnosis of pulmonary embolism remains complicated. Clinical suspicion and stratification should guide a diagnostic strategy for the comprehensive evaluation and diagnosis of patients with this disorder.
Nutrition in the intensive care unit
Authors: Hansen Chase C. , Dissanaike Sharmila 
Published: January 2017

Nutrition has evolved into an integral part of modern critical care for both medical and surgical patients. Multiple international societies now issue evidence-based guidelines to help clinician optimize their patients’ Nutrition. However, adherence to these guidelines throughout the country is poor, and education in nutrition is still lagging in medical school. The authors also highlight four key areas where evidence-based recommendations exist – timing of initiation of enteral feeding, calculating and meeting total daily requirements, use of gastric residual volumes to guide delivery, and interuption of feeding for procedures – but are currently often not followed. Reasons for this lack of adherence are explored, and potential solutions discussed.
Successful treatment of post-intubation tracheal stenosis with balloon dilation, argon plasma coagulation, electrocautery and application of mitomycin C
Authors: Fuller Audra , Sigler Mark , Kambali Shrinivas , Alalawi Raed 
Published: January 2017

Tracheal stenosis is an uncommon but known complication of endotracheal intubation and tracheostomy. Surgery is currently the definitive treatment for tracheal stenosis but carries a significantly higher risk for adverse events as it often involves complex procedures. Here we present our experience using topical application of mitomycin C, along with various bronchoscopic interventions, as a treatment for tracheal stenosis. The patients in our series developed tracheal stenosis post-intubation or post-tracheostomy. Each patient in our series underwent the same basic procedures involving rigid bronchoscopy and balloon dilation, ablation of granulation tissue with cryotherapy and argon plasma coagulation, and finally application of topical mitomycin C. Our experience with these four cases shows a good initial success rate with topical mitomycin C application for the treatment of tracheal stenosis. Most patients required a repeat intervention a few weeks later. Our results suggest that success with topical mitomycin C is more likely in post-intubation rather than post-tracheostomy tracheal stenosis. Bronchoscopic therapy and topical application of mitomycin C may work better as a bridge to definitive surgery rather than as a stand-alone therapy.
Implementing an electronic patient handover system
Authors: Oakley Ben , Hunter James B 
Published: January 2017

Background: Clear communication among health-care teams is paramount for safe patient care and effective handover. Advances in information technology have led to an increased use of electronic systems within modern health care. This quality improvement project introduced an electronic patient handover system that was intended to improve the accuracy of patient handover lists and be readily available to all members of the health-care team. Methods: A quality improvement project was undertaken to assess the effect of introducing an electronic patient handover system on maintenance workload and list accuracy. Results: List errors were common before the introduction of the electronic patient handover system, commonly patient location or a patient being incorrectly omitted from the list. These errors decreased significantly after the introduction of the electronic system (P<0.005 and 0.04 respectively). The workload associated with its maintenance also decreased (P<0.005) because many data fields were pre-populated by the software. This resulted in fewer instances of patients being missed on ward rounds (P<0.04). Conclusions: Through modifying existing information technology infrastructure, a centrally maintained, widely accessible electronic handover system was introduced. This reduced the workload associated with maintaining handover lists and the rate of errors.
Working with migrants’ memories in Italy: The Lampedusa dump
Authors: Triulzi Alessandro 
Published: January 2017

Abstract
The Archive of Migrant Memories aims at recording and diffusing migrant self-narratives in Italy so as to leave a visible trace of recently arrived migrants and their rising agency in Italian society. Retrieving oral and written records of migrants travelling to and landing on Italian soil intends to contrast, both physically and metaphorically, the hiding or cancellation mechanisms lying behind the collective unease surrounding immigration policies in today’s Italy. The recurrent dumping of migrant lives in the Mediterranean, particularly on its European southernmost gate at Lampedusa, symbolizes the careless disposal of irksome memories of migration within present-day Italian society. Here the remains of rotten boats derived from the repeated landings of irregular migrants on the Island and their human ‘waste’ – old shoes, clothes, cooking utensils, children’s toys, throw-away objects, but also water-stained documents, photos, holy books and individual writings such as letters, memoirs or diaries – lie to decompose as a vivid expression of what is not to be remembered in the nation’s past.
‘This big bum thing has taken over the world’: Considering black women’s changing views on body image and the role of celebrity
Authors: Appleford Katherine 
Published: January 2017

Abstract
Based on a small-scale project that explores racial distinctions in women’s attitudes towards weight loss and dieting, this article considers black women’s changing understandings of beauty and body image, and in particular young black women’s desire for a ‘slim-thick’ look. This is a body shape that brings together aspects of black and white beauty, seen to be embodied by Kim Kardashian, due to her full-figured bottom and thighs, and her very petite waist. The article argues that Kim Kardashian has been an important influence in shaping young women’s notions of attractiveness, by encouraging a common concept of body image and desirability across racial groups. Indeed, operating as an ‘exotic other’, who sits somewhere between black and white beauty, Kim Kardashian and the ‘slim-thick’ ideal perhaps offer an example of cultural assimilation, and yet they also work to exaggerate cultural stereotypes, encouraging a notion of beauty that is unrealistic, and far outside the reach of ordinary women.
Gender in South African newsrooms
Authors: Bosch Tanja 
Published: January 2017

Abstract
Academic research reveals a quantitative and qualitative underrepresentation of women in news production and content. This article presents findings of a qualitative study, exploring the experiences of women journalists in Cape Town, South Africa. Drawing on in-depth qualitative interviews, the research found that most journalists did not feel that their gender impacted daily newsroom routines, with many seeing their predominant coverage of ‘soft’ news items as a personal preference and not a structural constraint, even though they sometimes felt restricted by the dominance of normative news values. Concerns over personal safety were foregrounded, and some respondents highlighted the use of sexuality by women journalists to gain leverage with editors or sources. While the experiences of women journalists cannot be generalized, particularly since this study provides findings from a limited regional sample, it creates room for further studies in this area at national level and in other developing nations.
Dear researcher: Rethinking engagement with fan authors
Authors: Nielsen Ej 
Published: January 2017

Abstract
Scholars of online fan studies have engaged with fanfiction since at least the publication of Henry Jenkins’ Textual Poachers in 1992, and our access to it has only increased and improved with the explosion of online fan communities and with the development of massive, easily searchable online archives like fanfiction.net and archiveofourown. org. Much of this academic research and analysis, however, has taken place with no involvement or even knowledge on the part of the fan author. This unfortunate lack of engagement ignores the ways in which fan author practice is different from that of published authors due to the nature of fanworks and fan authorship, as well as intrafandom codes of ethics and the inherent power dynamics of researcher and research subject. Using direct input from fan authors and readers, this article proposes a more multifaceted take on best practices for fan studies researchers.
Invitation vs intrusion: Contemplating the ethics of teaching fan methods
Authors: Howell Katherine Anderson 
Published: January 2017

Abstract
The essay frames the ways in which fan artefacts can be ethically used in a university classroom setting. By offering ways to invite students to connect scholarship around fan studies and adaptation with fan materials, we lay the foundation for student understanding of fan spaces and fan works. The remix composition classroom positions fan artefacts in similar ways to academic conversations, and welcomes students to participate in multiple conversations.
Percolação de vinhaça em coluna de solo arenoso da formação Rio Claro
Authors: Basso Juliana Broggio , Soto Miguel A. Alfaro , Chang Hung Kiang 
Published: January 2017

A vinhaça é um resíduo amplamente utilizado na agricultura da cana-de-açúcar, entretanto pouco se conhece sobre o comportamento dos íons presentes na vinhaça quando aplicada no solo. Esse estudo tem a finalidade de avaliar a capacidade de retenção e de transporte de espécies iônicas da vinhaça em um solo arenoso, comumente utilizado no cultivo de cana-de-açúcar. Neste trabalho, são apresentados os parâmetros de transporte dos íons K+, Ca2+ e Mg2+ da vinhaça por meio de Breakthrough Curves (BTC), em um solo arenoso proveniente da Formação Rio Claro, presente no interior do Estado de São Paulo. O experimento foi realizado em colunas de solo deformado, em condição saturada e de regime permanente. Durante a percolação, foram monitorados o valor de pH da solução, a condutividade elétrica, a demanda bioquímica e química de oxigênio (DBO e DQO) da vinhaça percolada e a condutividade hidráulica. Os parâmetros de transporte dos íons foram obtidos a partir de um ajuste numérico empregando o software STANMOD. Pelos resultados obtidos, verificou-se que houve interação entre o soluto e o solo, uma vez que o fator de retardamento (R) foi superior a 1. Baseado nos resultados de R, a ordem de adsorção foi K+ > Ca2+ > Mg2+. Durante a percolação, houve diminuição gradual da condutividade hidráulica e do valor de pH do percolado, mas não houve redução dos valores de DBO e DQO do percolado durante o período do experimento.
The Correlation Between Personality Dimensions and Young People's Choice of a Medical Career
Authors: Popa Cosmin Octavian , Rus Adrian 
Published: January 2017

Abstract

Objective: The research assumes that there is a correlation between personality dimensions Extraversion and Conscientiousness which mean autonomy, ambition and consistency of purpose, self-efficacy and determination for young people who want to aspire to a medical career.

Methods: In this study’s target group were included 130 students aspiring to a medical career, that participated in the summer school organized by UMF Tirgu-Mures in 2016, of which 25 (19%) male and 106 (81%) female, average overall age group being 17.23.

Results: Within the female group, the Pearson cross-correlation coefficient of Openness and Conscientiousness is r. Pearson (105) = − .20, p <0.05. The Pearson coefficient of cross-correlation between Extraversion and Conscientiousness is = − .20, p <0.05. The Pearson coefficient of cross-correlation between emotional stability and conscientiousness is r. Pearson (105) = .36, p <.001. In the male group, the Pearson cross-correlation coefficient between the Extraversion and Conscientiousness personality dimensions is r. Pearson (N = 25) = −.39 where p <0.05.

Conclusions: The Extraversion dimension of personality is a dynamic factor and motivator only when it is correlated with the Conscientiousness personality dimension. This indicates dynamism and autonomy, persistence in achieving goals, ambition, high motivation, interpersonal social intelligence and emotional stability, resulting a personality profile that matches one of the aspirants to a medical career.
FDI-led tourism growth hypothesis: empirical evidence from Croatian tourism
Authors: Perić Jože , Radić Maja Nikšić 
Published: January 2017

AbstractThe aim of this paper is to explore the causal relationship between the foreign direct investment (FDI) stock in tourism and the number of international tourist arrivals in the Republic of Croatia in the period from 2000 to 2012. The study uses quarterly time series data from 2000(1) to 2012 (4). The augmented Dickey–Fuller (ADF) test was carried out to test the stationarity of variables. The Johansen co-integration test was used to test a long-term relationship between the variables, and given the absence of the same, the vector autoregression (VAR) model is set up. The Granger and Toda–Yamamoto test was conducted to test a short-run causality between the selected variables. The results indicated a one-way short-run causality relationship running from FDI in tourism to international tourism arrivals at a high significance level of 1%. The research results emphasise the need to establish a favourable macroeconomic environment, as well as a policy of incentive investment measures specifically targeted at the tourism sector. This would enhance the conditions for higher FDI inflow essential for qualitative and quantitative positioning of Croatian tourism compared to competing destinations.
The Analysis of Orders of Perishable Goods in
Relation to the Bullwhip Effect in the Logistic
Supply Chain of the Food Industry: a Case Study
Authors: Chocholáč Jan , Průša Petr 
Published: January 2017

Abstract
The bullwhip effect generally refers to the phenomenon
where order variability increases as the orders
move upstream in the supply chain. It is serious problem
for every member of the supply chain. This effect begins
at customers and passes through the chain to producers,
which are at the end of the logistic chain. Especially food
supply chains are affected by this issue. These chains are
unique for problems of expiration of goods (particularly
perishable goods), variable demand, orders with quantity
discounts and effort to maximize the customer satisfaction.
This paper will present the problem of the bullwhip effect
in the real supply chain in the food industry. This supply
chain consists of approximately 350 stores, four central
warehouses and more than 1000 suppliers, but the case
study will examine 87 stores, one central warehouse and
one supplier in 2015. The aim of this paper is the analysis
of the order variability between the various links in this
chain and confirmation of the bullwhip effect in this chain.
The subject of the analysis will be perishable goods.
Crop and Livestock Insurance as Risk Management Instrments in Polish Agriculture Compared to the EU Regulations
Authors: Lipińska Izabela 
Published: January 2017

AbstractRisk management in agricultural production is currently one of the objectives of the Common Agricultural Policy. In order to secure the income of agricultural producers certain forms of support at both the EU and the national levels have been established, including making subsidized crop and livestock insurance contracts. The paper aims at determining the condition of the mentioned insurance contracts in Poland and answering the question to what extent a certain insurance system implemented by the national legislator serves its purpose as a risk management instrument. The conclusion is that as for compulsory contracts, since their scope is limited compared to the EU regulations, they are still not an effective measure, which partly results from the application ofad hocsupport by the State. The legislative solutions in that regard should, hopefully, bring some positive developments.
Modelling of Efficiency Change as a Source of Economic Growth in Agriculture
Authors: Bezat-Jarzębowska Agnieszka , Rembisz Włodzimierz 
Published: January 2017

Abstract
In the paper, the subject of economic growth in agriculture was raised. One of the determinants of this process, namely an efficiency change was under the assessment. The aim of the paper was to evaluate the changes of efficiency in the Polish agriculture. In the study, a stochastic parametric production function was used.
Beta Stability Over Bull and Bear Market on the Warsaw Stock Exchange
Authors: Dębski Wiesław , Feder-Sempach Ewa , Świderski Bartosz 
Published: January 2017

Abstract
Beta parameter is one of the commonly used measures of the investment risk of individual stock or portfolio. It plays a crucial role in modern portfolio theory particularly in management of financial investment portfolios. In the field of beta parameter, numerous studies have been conducted, especially beta properties stability in the context of the stock market cycle phases, measuring frequency of rate of return, and the length of a sample period. There are much fewer studies concerned beta parameter in the countries of Central and Eastern Europe which have undergone systemic transformation at the end of the previous century. From a scientific point of view, it is interesting to know how the beta parameter behaves in these countries.
The main goal of this article is to examine the beta parameter stability over bull and bear market conditions on the Warsaw Stock Exchange. The paper presents an analysis of beta stability for 134 stocks of the largest companies listed at the WSE during years 2005–2013. To verify statistically the hypothesis of beta parameter stability, we used monthly returns in the Sharpe’s single-index model. In the first part of the article, we present a brief review of the literature and methodology of the study, while in the second part, the obtained results and conclusions are shown.
The Model of Demand and Inventory in a Decline Phase of the Product Life Cycle
Authors: Hachuła Piotr , Schmeidel Ewa 
Published: January 2017

Abstract
In the paper, the mathematical model of demand and inventory is studied from the perspective of its applications in real business cases. The model is formulated with three difference equations of first order. Three scenarios focused on the last phase of the product life cycle, a decline, are investigated and commented upon.