bluuebunny/crossref_metadata_2025_split huggingface dataset:
Urban Waste Fertilizer: Effects on Yield, Nutrient Dynamics, and PTE accumulation
Authors: Reimer Marie , Kurt Möller , Magid Jakob , Bruun Sander 
Published: September 2024

Abstract

Recycling nutrients contained in urban wastes to agriculture is essential in a circular society. This study simultaneously compares different recycled fertilizers (household waste compost, sewage sludge, human urine) with mineral fertilization and animal manures. Tested were their long-term effects on yield, nutrient budgets, potentially toxic element (PTE) accumulation, and nitrogen (N)/carbon cycle (a.o. N efficiency, N losses, soil carbon). Therefore, data from a long-term field trial and predictions from the soil-plant-atmosphere model DAISY were evaluated. Based on trial data, human urine performed similar to the mineral fertilization for yield, N efficiency (MEF = 81%), and nutrient budget, while sewage sludge and compost were more like animal manures with lower yields, N efficiencies (MEF 70% & 19% respectively) and higher nutrient imbalances, especially P and S surpluses. Compost and sewage sludge applications resulted in net PTE inputs. Yet, plant uptake and soil accumulation seemed neglectable. Model outputs predicted N losses of 34–55% of supplied N. Losses were highest for compost, followed by deep litter, manure, sewage sludge, human urine, mineral fertilization, and slurry. Nitrate leaching was the main loss pathway (14–41% of N input). Within the compost and straw-rich manure treatments, about 25% of applied N, were stored in the soil which was accompanied by an increase in soil carbon. The study suggests substitution of established fertilizers with recycled ones is feasible. Thereby each fertilizer has advantages and disadvantages, and thus should be utilized according to their strength or in mixtures.
H3K18 lactylation-mediated nucleotide-binding oligomerization domain-2 (NOD2) expression promotes bilirubin-induced pyroptosis of astrocytes
Authors: Li Jing , Li Siyu , Sun Qian , Li Ling , Zhang Yan , Hua Ziyu 
Published: September 2024

Abstract

Histone lactylation, a newly glycosis-related histone modification, plays a crucial role in the regulation of gene expression in various immune cells. However, the role of histone lactylation in astrocytes remains unclear. Here, this study showed that the H3K18 lactylation (H3K18la) levels were upregulated in primary astrocytes under unconjugated bilirubin (UCB) stimulation and hippocampus of bilirubin encephalopathy (BE) rats. Inhibition of glycolysis decreased H3K18la and attenuated pyroptosis both in vitro and in vivo. CUT& Tag and RNA-seq results revealed that H3K18la was enriched at the promoter of nucleotide-binding oligomerization domain 2 (NOD2) and promoted its transcription. Moreover, NOD2 boosted the activation of downstream mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) signaling pathways, which exacerbated the neuroinflammation of BE. Collectively, this study provides a novel understanding of epigenetic regulation in astrocytes, and interruption of the H3K18la/NOD2 axis may represent a novel therapeutic strategy for treating bilirubin encephalopathy.
A Unity Gain Cell-Based Current-Mode Universal Filter
Authors: Alpaslan Halil 
Published: September 2024

Abstract

This paper presents a practical implementation of a current-mode universal filter circuit using unity-gain cells, i.e., voltage and current followers. The presented universal filter uses four passive components and three unity-gain cells. Two grounded capacitors in the presented universal filter are appropriate for the integrated circuit manufacturing process. However, a resistive matching constraint is required for the high-pass filter, notch filter, and all-pass filter responses. 0.18 µm CMOS technology parameters and supply voltages of ± 1 V are used in the SPICE simulations. Several experimental studies verify the theory.
Hybrid random carrier-based noise suppression for automotive electronic water pumps
Authors: Ma Xipei , Feng Xiaodan , Fan Pingqing , Hu Xinyang , Li Yawei 
Published: September 2024

Abstract

To effectively mitigate the electromagnetic noise from automotive electronic water pump, this paper proposes and validates an electromagnetic noise suppression method based on hybrid random carrier technology. By leveraging the control model of the automotive electronic water pump and SVPWM harmonic theory, the paper analyzes the relationship between harmonics and electromagnetic noise in the control system. and studies the mechanism of random signal. Building upon control model and theory of vehicle electronic water pumps, the paper introduces randomized carrier wave mixing., Simulation results are then analyzed spectrally using the power spectrum transform method to verify the suppression ability of the carrier randomization technique on the higher harmonics. Furthermore, experimental verification is conducted through a noise characteristics experimental platform, affirming its correctness and effectiveness. This method significantly improves the high-frequency vibration and noise of the automotive electronic water pump without compromising the original control system or requiring additional hardware inputs. Therefore, the research findings of this paper offer a novel solution to reduce the electromagnetic noise from the automotive electronic water pump, holding significant practical application value for water pump motor development.
Generating Patient’s Electronic Health Records with Unseen Diseases Using Ontology-enhanced Generative Adversarial Networks
Authors: Sun Chang , Dumontier Michel 
Published: September 2024

Abstract

The generation of realistic synthetic personal health data such as those found in electronic health records may be useful for fundamental research, applied AI models, and to examine safeguards for data privacy. Generative Adversarial Networks (GANs) have been employed for this purpose, but their ability to generate data is largely constrained by the limitations of the data they are trained on. Consequently, these models fail to generate realistic synthetic data relevant to rare diseases or complex conditions. In this paper, we propose a novel generative framework (Onto-CGAN) that integrates knowledge drawn from disease ontologies, with conditional GAN models to to generate realistic synthetic health data for diseases not present in the training data. We examine the quality of the generated data through 1) distributions of single variables, 2) correlation coefficients of variable pairs, and 3) predictive model performance using four machine learn- ing models. Our results demonstrate that Onto-CGAN can generate unseen data with statistical characteristics comparable to real data, and significantly improve the training of machine learning models in classifying diseases absent from the training set. This work represents a first step towards generating complex synthetic health data with characteristics that closely mimic those of real data such that they can be used in situations where there is a paucity of available data, and may find applications for data augmentation, hypothesis generation, and pre-clinical validation of clinical models.
BMP receptor 2 inhibition regulates mitochondrial bioenergetics to induce synergistic cell death with BCL-2 inhibitors in leukemia and NSLC cells
Authors: Toussaint Ashley , Singh Manohar , Wang Guoquiang , Driscoll Monica , Bhatt Vrushank , Ndong Jean De La Croix , Shuaib Sahil , Zoltowski Harrison , Gilleran John , Peng Youyi , Tsymbal Anastassiia , Jia Dongxuan , Roberge Jacques , Chiou Hellen , Guo Jessie Yanxiang , Herranz Daniel , Langenfeld John 
Published: September 2024

Abstract

Background
Bone morphogenetic protein (BMP) signaling cascade is a phylogenetically conserved stem cell regulator that is aberrantly expressed in non-small cell lung cancer (NSLC) and leukemias. BMP signaling negatively regulates mitochondrial bioenergetics in lung cancer cells. The impact of inhibiting BMP signaling on mitochondrial bioenergetics and the effect this has on the survival of NSLC and leukemia cells are not known.
Methods
Utilizing the BMP type 2 receptor (BMPR2) JL189, BMPR2 knockout (KO) in cancer cells, and BMP loss of function mutants in C elegans, we determined the effects of BMPR2 inhibition (BMPR2i) on TCA cycle metabolic intermediates, mitochondrial respiration, and the regulation of mitochondrial superoxide anion (SOA) and Ca++ levels. We also examined whether BMPR2i altered the threshold cancer therapeutics induce cell death in NSLC and leukemia cell lines. KO of the mitochondria uniporter (MCU) was used to determine the mechanism BMPR2i regulates the uptake of Ca++ into the mitochondria, mitochondrial bioenergetics, and cell death.
Results
BMPR2i increases mtCa++ levels and enhances mitochondrial bioenergetics in both NSLC and leukemia cell lines that is conserved in C elegans. BMPR2i induced increase in mtCa++ levels is regulated through the MCU, effecting mitochondria mass and cell survival. BMPR2i synergistically induced cell death when combined with BCL-2 inhibitors or microtubule targeting agents in both NSLC and leukemia cells. Cell death is caused by synergistic increase in mitochondrial ROS and Ca++ levels. BMPR2i enhances Ca++ uptake into the mitochondria induced by reactive oxygen species (ROS) produced by cancer therapeutics. Both acute myeloid leukemia (AML) and T-cell lymphoblastic leukemia cells lines were more responsive to the JL189 alone and when combined with venetoclax or navitoclax compared to NSLC.
Comparative analysis of decision tree, time series, and semi-distributed hydrological models for runoff prediction in snowmelt-influenced and human-activity-intensive basins: a case study of the Shiribeshi-Toshibetsu basin, Japan
Authors: Chen Yuechao , Liu Jiawen , Jiang Yaru , Gao Jiajia , Han Yaoyao 
Published: September 2024

ABSTRACT

This study evaluates the performance of decision tree model (XGBoost), time series model (LSTM), and semi-distributed hydrological model (HBV) in simulating daily runoff in a watershed with significant snowmelt contributions and intensive human activity. Daily runoff data from the Shiribeshi-Toshibetsu basin in Japan, spanning the period from 1998 to 2015, were used for model training, with data from 2016 to 2019 for validation. Comparative analysis reveals that the XGBoost model outperforms the LSTM and HBV models,achieving a Nash–Sutcliffe Efficiency (NSE) of 0.94, compared to 0.85 and 0.84 for the LSTM and HBV models, respectively. Additionally, Partial Dependence Plots (PDPs) were utilized to investigate the nonlinear impacts of climatic factors on runoff, identifying precipitation, average temperature, and wind speed as the most significant drivers. Specifically, the relationship between temperature and runoff follows a unique pattern: runoff initially increases with rising temperatures, then decreases, and subsequently increases again. These findings underscore the robustness of decision tree models in handling complex hydrological data and highlight the importance of understanding the intricate interactions between climatic variables and runoff. This study provides scientific support for water resource management in similar watersheds under changing climatic conditions.
Enhancing Cement Stabilization for Lateritic Soil in the Takie Area of Ogbomoso
Authors:   Department of Architecture University of Ibadan Ibadan, Nigeria, Obakin Olufunmilola Adetayo , Oladunmoye Oluranti Mobolaji 
Published: September 2024

The study investigates "Optimizing Cement Stabilization for Lateritic Soil in the Takie Area of Ogbomoso" and presents a comprehensive analysis of geotechnical properties. The research encompassed particle size determination and Atterberg limits testing to classify the samples, primarily composed of lateritic soil. The results detailed the particle size distribution and indicated the soil’s composition, predominantly sand with gravel and unaccounted finer silt content. The Atterberg limits testing revealed variations in plastic and liquid limits across different cement percentages. Additionally, dynamic and static compaction tests were performed, indicating Optimum Moisture Content (OMC) and Maximum Dry Density (MDD). The static compaction involved replacing proportions of bulk sand with cement for each percentage addition. The study achieved its objective of understanding soil properties for stabilization purposes, offering insights into the impact of varying cement content on soil characteristics and compaction. The abstract emphasizes the comprehensive investigation into lateritic soil properties and the influence of cement stabilization, vital for engineering applications in the Takie area of Ogbomoso. Keywords: Lateritic Soil, Cement Stabilization, Geotechnical Properties, Atterberg Limits, Compaction	Testing Aims Research Journal Reference Format: Obakin, O.A. & Oladunmoye, O.M. (2022): Enhancing Cement Stabilization for Lateritic Soil in the Takie Area of Ogbomoso. Advances in Multidisciplinary and Scientific Research Journal Vol. 8. No. 1. Pp 82-91. dx.doi.org/10.22624/AIMS/V8N1P8
The inflce of Heracleum sosnowskyi Manden invasion on functional traits of Corydalis nobilis (L.) Pers (by the example of the MBG RAS collection of living plants)
Authors: Стогова А.В. , Воронина О.Е. , Зуева М.А. , Мамонтов А.К. 
Published: September 2024

Инвазии агрессивных чужеродных видов, таких как гигантские борщевики, в последние годы привлекают внимание многих ботаников. При этом реакция отдельных растений на присутствие инвайдеров для большинства представителей культурной и природной флоры не изучена. В работе приведены результаты исследований функциональных признаков весеннего эфемероида Corydalis nobilis при внедрении на опытные участки Heracleum sosnowskyi. Произрастание в общем локалитете с H. sosnowskyi приводит к снижению запасов органического вещества в фитомассе C. nobilis и уменьшению вклада листьев в общую массу надземной части растений. Выявлены изменения в пигментном комплексе листьев C. nobilis, проявляющиеся в увеличенном содержании суммы хлорофиллов вначале вегетационного периода. В изученных местообитаниях C. nobilis проявляет конкурентно-рудеральную жизненную стратегию. В целом H. sosnowskyi оказывает крайне неблагоприятное воздействие на C. nobilis, и жизненность особей этого вида сильно снижается.
In recent years, invasions of aggressive alien species, such as a giant hogweed, have at- tracted the attention of many botanists. However, the response of individual plants to the presence of invaders has not been studied for most representatives of the cultivated and natural floras. The article presents the results of studying functional traits of the spring ephemeroid Corydalis nobilis when Hera- cleum sosnowskyi is introduced into experimental plots. Sharing a common locality with H. sosnowskyi causes a decrease in organic reserves of C. nobilis phytomass and reduced contribution of its leaves to the total mass of the aboveground parts of plants. We have revealed changes in the pigment complex of C. nobilis leaves, manifested as an increased content of the total chlorophyll in the beginning of the growing season. In the studied habitats, C. nobilis exhibits a competitive-ruderal life strategy. In general, H. sosnowskyi has an extremely adverse effect on C. nobilis and vitality ofthe latter.
Mollusks in the nests of passerine birds in the south-east of Belarus
Authors: Островский А.М. 
Published: September 2024

Изучены сборы раковин моллюсков из 30 гнезд 11 видов воробьинообразных птиц, полученные в 2020–2024 гг. на территории Гомельской области (юго-восток Беларуси). Установлена принадлежность 139 раковин к 29 видам моллюсков из 19 семейств. На основании повреждений раковин и их состояния обсуждаются три способа, посредством которых раковины могли оказаться в птичьих гнездах: как добыча пернатых, в ходе самостоятельных перемещений улиток или же в результате переноса птицами уже пустых раковин.
The material was collected in the period from 2020 to 2024 on the territory of the Gomel region (south-east of Belarus). In 30 nests of 11 species of passerine birds, we have found 139 shells belonging to 29 species of mollusks of 19 families. Based on the shells’ state and their damage, three ways of the material appearance in the bird nests are discussed: 1) as a prey of birds, 2) a result of snails’ migration, 3) bringing of empty shells by birds.
Zooplankton of lakes Borodaevskoe and Ferapontovskoe (Russky Sever (Russian North) National Park)
Authors: Лобуничева Е.В. , Литвин А.И. , Думнич Н.В. 
Published: September 2024

Представлены результаты исследований зоопланктона озер Бородаевского и Ферапонтовского (Национальный парк «Русский Север», Вологодская область) в 1975, 2008 и 2021 гг. Зоопланктон водоемов сходен по составу. Всего в озерах зарегистрировано 70 видов зоопланктона (Rotifera – 21, Cladocera – 32, Copepoda – 17). Ранее в озерах был отмечен реликтовый Limnocalanus macrurus. Обилие зоопланктона выше в более мелководном оз. Бородаевском. Соотношение групп зоопланктона в водоемах в отдельные периоды исследований сходно. Наибольшая численность характерна для ракообразных. Комплекс доминантов насчитывал 5–7 видов (Kellicottia longispina, Diaphanosoma brachyurum, Daphnia сucullata, D. сristata, Bosmina coregoni, Mesocyclops leuckarti, Thermocyclops oithonoides). Обилие зоопланктеров в озерах зависело от температуры воды. При ее увеличении на 5 °С летом 2021 г. наблюдался рост численности и биомассы зоопланктона глубоководных участков озер.
The zooplankton of the lakes Borodaevskoe and Ferapontovskoe (Russky Sever (Russian North) National Park) has been studied in 1975, 2008, and 2021. The zooplankton composition is similar in the lakes. In total, 70 zooplankton species are registered (21 species of Rotifera, Cladocera, 32, Copep- oda, 17). The relict species Limnocalanus macrurus has been found earlier in the lakes. The zooplankton abundance is higher in the shallower Lake Borodaevskoye. The ratio of zooplankton groups in the water bodies was similar throughout the study period, with crustaceans as dominating group. The core of dom- inants includes 5 to 7 species (Kellicottia longispina, Diaphanosoma brachyurum, Daphnia сucullata, D. сristata, Bosmina coregoni, Mesocyclops leuckarti, and Thermocyclops oithonoides). The zooplankton abundance depends on the water temperature. As the latter has increased by 5 °С in summer 2021, there was an increase in the abundance and biomass of zooplankton in deep water areas of the studied lakes.
Pengaruh Pertumbuhan Ekonomi Dan Tingkat Pengangguran Terbuka (TPT) Terhadap Kemiskinan Di Provinsi Jambi
Authors: Mawaddah Alya , Abror Ahmad Holil , Lestari Apika , Nengsih Titin Agustin 
Published: September 2024

This study analyzes the impact of economic growth and the open unemployment rate on poverty in Jambi Province using panel data from 11 regencies/cities during the 2020-2023 period. The panel data regression method with a random effect model approach was used in the analysis. The results show that economic growth has a negative and insignificant effect on poverty, while The results show that while the open unemployment rate has a positive and significant impact on poverty,economic growth has a negative and insignificant impact on poverty. At the same time, both economic growth and the open unemployment rate have a significant impact on poverty. influence on poverty in Jambi Province. These findings imply that poverty alleviation efforts need to consider improving economic growth and reducing the unemployment rate simultaneously to achieve optimal results.
Relationship between eHealth Literacy and Health Promoting behaviors among nursing students
Authors: Agapito Leana Flordeliza , Cortez Alyssa Marielle , Fong Auryjeena , Sanchez Christiene Jann , Calong Calong Kathyrine , Balaria Carissa Juliana , Soriano Gil 
Published: September 2024

Background: Utilizing health literacy is important in establishing knowledgeable health advancements and practices, which can become deterrents to promoting a healthy lifestyle. Technological advancements improve health information availability and accessibility that potentially affect the users’ proficiency and their capability in applying the accessed health information. However, accessing health information via IT for health promotion requires e-health literacy.
Purpose: The objective of the study is to determine the relationship between eHealth literacy and health-promoting lifestyle behaviors among nursing students.
Methods: Descriptive-correlational study was applied to 131 nursing students recruited through a purposive sampling method from a nursing school in Philippines. The researchers adopted original English version of the e-Health Literacy Scale and Health-Promoting Lifestyle Profile II (HPLP) to collect the data. The gathered data were analyzed using descriptive analysis; frequency, percentage, mean, standard deviation, and test the correlation using Pearson's r correlation.
Results: A total of 131 nursing students were employed in the study with a mean age of 20.14 (±1.22). Participants were female (71.8%) and are Level 1 students (44.3%) The mean of the total sum score for eHealth literacy was 31.24 (±4.30) while the over-all item mean was 3.92 (±0.54). On the other hand, the health-promoting behavior has a mean score of 2.43 (±0.43) while its subscales have a mean score of 2.46 (±0.45) for nutrition, 2.45 (±0.62) for physical activity, and 2.39 (±0.47) for health responsibility. It was found that eHealth literacy had a significant relationship with the students’ health-promoting behavior (r=0.245, p=0.005). Hence, students who have a high level of eHealth literacy are more inclined to perform healthy behaviors.
Conclusion: The results of this study showed that the development of strategies to improve the e-health literacy of nursing students may contribute to the maintenance of their health-promoting behaviors. Identified intervention strategies based on eHealth literacy are needed to encourage healthy practices, which may reduce risks of illnesses due to unhealthy lifestyle behaviors among nursing students.
Test Section Design for Measuring the Drag Coefficient of a Suborbital Rocket Model at Ma 2.45
Authors: Wasilczuk Filip , Kurowski Marcin , Flaszyński Paweł 
Published: September 2024

ABSTRACT
This study investigates the drag coefficient of three models of suborbital rockets with different nosecones. A test section allowing for force measurement of a 1:50 scale rocket model was designed with the aid of numerical simulations. The velocity obtained in the wind tunnel corresponds with a Mach number of 2.45. RANS simulations were used in verifying operating parameters, as well as testing the support configurations for connecting the model with the bottom wall of the tunnel section. Pressure distribution measurements on the top and bottom walls of the wind tunnel matched simulation results well. The shock structure in the test section was visualized using the schlieren technique, revealing that the measured angle of the main shock generated at the tip of the rocket matched the simulation data. Finally, the measured forces were compared with simulations for one of the nosecone configurations. Despite very good agreement for pressure distribution on the wind tunnel walls and shock structure, a significant mismatch in the forces measured was nevertheless observed: the simulated CD (0.57) being four times larger than that obtained in measurements (0.138). Further analysis of the test section is required to pinpoint the source of discrepancies and redesign the force measurement system to achieve improved force results.