bluuebunny/crossref_metadata_2025_split huggingface dataset:
Integrating eugenol with intensive care in leukemia patients: exploration of pro-apoptotic potential against HL-60, human leukemia cell line
Authors: Haseeb Khaliq Hafiz Muhammad , Bughio Rabia , Nangdev Pirya , Aziz Owais , Javed Warda 
Published: October 2024

Objective: The objective of this in-vitro study was to explore the pro-apoptotic potential of eugenol (4-allyl-2-methoxyphenol) on Human Leukemia-60 (HL-60) cell line as a potent phytochemical in intensive care setting to leukemia patients.
Methodology: After formal approval by all of the respective ethical committees, this study was simultaneously conducted at all respective institutional departments. The study included culturing HL-60 cell line and its treatment with serial concentrations of eugenol for calculation of subsequent IC50 values (half-maximal inhibitory concentration) via MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide] assay, expression analysis of gene, comparative analysis of relative gene fold (Intrinsic Biomarkers Caspase-3, Caspase-9) as apoptosis mediator markers followed by RT-qPCR. Cellular apoptotic morphology was confirmed via Hoechst 333258 staining.
Results: For HL-60 cell line, the IC50 of eugenol (14.1 uM) showed high gene expression of pro-apoptotic biomarkers (Caspase-3 and Caspase-9). Hoechst 333258 staining showed prominent apoptotic bodies leading to nuclear fragmentations.
Conclusion: Eugenol proved to possess robust pro-apoptotic potential leading to diagnostic efficacy against leukemia HL-60 cell line. Further studies would help in identifying key mechanisms by which eugenol exhibits anti-cancer potential against HL-60 cell lines.
Abbreviations: HL-60 - Human Leukemia-60; IC50 - Half-Maximal Inhibitory Concentration
Keywords: Eugenol, Pro-apoptotic Effects, Intensive Care, Anti-Cancer Mechanisms, HL-60, Natural Chemotherapeutics
Citation: Khaliq HMH, Bughio R, Nangdev P, Aziz O, Javed W. Integrating eugenol with intensive care in leukemia patients: exploration of pro-apoptotic potential against HL-60, human leukemia cell line. Anaesth. pain intensive care 2024;28(5):871−875; DOI: 10.35975/apic.v28i5.2491
Received: June 18, 2024; Reviewed: August 03, 2024; Accepted: August 11, 2024
Comparative evaluation of intrathecal hyperbaric bupivacaine alone versus combined with dexmedetomidine for cesarean sections
Authors: Qureshi Rida Amjad , Jadoon Humaira , Shabbir Mahnoor 
Published: October 2024

Background & Objective: This study examined the use of dexmedetomidine 5 μg as an adjuvant to 10 mg of intrathecal hyperbaric 0.5% bupivacaine in elective cesarean sections and aimed to assess dexmedetomidine’s impact on block characteristics and post-operative pain management. As spinal anesthesia is commonly employed for cesarean deliveries, the study seeks to determine whether the addition of dexmedetomidine as an adjuvant can prolong the duration and enhance the quality of the block, leading to improved post-operative pain relief.
Methodology: This randomized controlled trial included 100 parturients undergoing elective cesarean section over a period of six months. Participants were allocated to either Group B or Group D using a non-random consecutive sampling technique. In Group D, 2 mL of 0.5% bupivacaine mixed with 0.05 mL of dexmedetomidine (5µg) was injected intrathecally, while Group B received 2 mL of 0.5% hyperbaric bupivacaine along with an equivalent volume of saline. Sensory and motor block assessments were conducted prior to the start of surgery. Post-operatively, the duration of motor block and post-operative pain relief were assessed.
Results: The addition of dexmedetomidine as an adjuvant to intrathecal bupivacaine resulted in significant reductions in the onset time of sensory block (4.22 ± 0.79 min vs 5.66 ± 1.21 min) and motor block (4.20 ± 0.81min vs 6.32 ± 1.20 min) (P < 0.001). Furthermore, the duration of motor block was longer in the dexmedetomidine + bupivacaine group compared to the bupivacaine alone group (7.32 ± 0.95 h vs 4.38 ± 1.27 h). Additionally, patients who received intrathecal dexmedetomidine as an adjuvant to bupivacaine experienced significantly longer durations of post-operative analgesia (7.32 ± 0.95 h) as compared to the bupivacaine alone group (4.38 ± 1.27 h) (P < 0.001).
Conclusion: Dexmedetomidine as an intrathecal adjuvant to hyperbaric bupivacaine extends the duration of analgesia and motor block, providing prolonged pain relief. Additionally, it exhibits an early onset of sensory and motor block, ensuring prompt pain relief and rapid anesthesia onset.
Clinical Trial Registration: [www.clinicaltrials.gov], identifier: ID NCT05469529
Abbreviations: CS - cesarean section; OT - Operation Theater; SA - Spinal anesthesia; VAS - visual analogue scale;
Keywords: cesarean section, dexmedetomidine, bupivacaine, spinal anesthesia
Citation: Qureshi RA, Jadoon H, Shabbir M. Comparative evaluation of intrathecal hyperbaric bupivacaine alone versus combined with dexmedetomidine for cesarean sections. Anaesth. pain intensive care 2024;28(5):866−870.
DOI: 10.35975/apic.v28i5.2558
Received: December 03, 2023; Reviewed: December 15, 2023; Accepted: August 16, 2024
C-reactive protein/albumin ratio versus lactate/albumin ratio as an outcome predictor for patients with sepsis and septic shock in hospital stay
Authors: Abdou Khaled , Salama Madonna Mounir , Abdelmohsen Samia , Salem Sameh , Ali Ahmed 
Published: October 2024

Background & Objective: Pre-emptively identifying individuals at risk of developing sepsis and septic shock remains challenging. In septic patients, the Lactate/Albumin Ratio (LAR) and C-reactive protein (CRP)/Albumin ratio (CAR) have been suggested to be promising prognostic indicators for prediction of intensive care unit (ICU) mortality. We compared the prognostic values of CAR and LAR in patients with sepsis and septic shock.
Methodology: Eighty adult patients diagnosed with sepsis and admitted to the ICUs of Ain Shams University Hospitals, were included in this observational prospective study. CRP levels, serum lactate, serum albumin, complete blood count (CBC), procalcitonin levels, and SOFA scores were assessed upon admission, with subsequently observing 28-day mortality among the selected patients.
Results: CAR values were comparable between the mortality and survival groups (P = 0.807). However, LAR values were significantly elevated in the mortality group vs the survival group (P = 0.044). ROC analysis for mortality indicated that LAR had an AUC of 0.633 at a cutoff value > 0.68, achieving sensitivity and specificity of 89.4% and 21.2%, respectively. In contrast, CAR had an AUC of 0.484 at a cutoff value ≥ 1.54, with sensitivity and specificity values of 63.8% and 57.6%, respectively. Length of ICU stay (P < 0.001), duration of mechanical ventilation (P < 0.001), cardiovascular support (P < 0.001) and the need for renal replacement therapy (P < 0. 039), were increased in the mortality group compared to the survival group.
Conclusion: Lactate/albumin ratio is superior and more reliable bio-marker predictor compared to C-reactive protein (CRP)/albumin ratio for ICU mortality.
Abbreviations: CAR - C-reactive protein/albumin ratio; CRP - C-reactive protein; ICU - intensive care unit; LAR - Lactate/Albumin Ratio;
Keywords: Albumin; CRP To Albumin Ratio; Lactate; Lactate to Albumin Ratio; Mortality; Sepsis; Septic Shock; SOFA; Survival
Citation: Abdou K, Mounir M, Abdelmohsen S, Salem S, Ali A. C-reactive protein/albumin ratio versus lactate/albumin ratio as an outcome predictor for patients with sepsis and septic shock in hospital stay. Anaesth. pain intensive care 2023;28(5):901−907; DOI: 10.35975/apic.v27i5.2571
Received: July 29, 2024; Reviewed: August 23, 2024; Accepted: August 28, 2024
“Preceptor, eu?” Ensaio teórico sobre o papel do ensino na residência em saúde
Authors: Gomes Lopes Fernanda , Mota Silva Rodrigues Emanuelly 
Published: October 2024

A construção dos processos educativos tem exigido uma ampliação do modelo tradicional de ensino em prol de uma educação dialógica. A residência multiprofissional em saúde é uma modalidade de especialização lato sensu, com carga horária dividida entre atividades pedagógicas teóricas, práticas e teórico-práticas. Essas atividades são facilitadas por preceptores, e o SUS é a principal escola. Este ensaio objetiva trazer discussões sobre a identidade docente e a necessidade de formação da preceptoria para execução de seu papel. Para subsidiar essa reflexão, utilizaremos como metodologia o ensaio teórico, permitindo a construção de uma análise crítica, a partir de uma exposição reflexiva e argumentativa dos autores. Constata-se a necessidade de qualificação desses profissionais, para além do aprendizado de competências voltadas à sua atribuição.
Abstract
The construction of educational processes requires an expansion of the traditional teaching model in favor of dialogical education. The multiprofessional health residency is a lato sensu specialization modality with a workload divided between theoretical, practical, and theoretical-practical teaching activities. Preceptors facilitate these activities, and SUS is the main school. This essay aims to discuss teaching identity and the need for preceptorship training to fulfill its role. To support this reflection, we will use theoretical essay as methodology, promoting a critical analysis construction, based on the author’s reflective and argumentative exposition. These professionals need to be qualified, in addition to learning the skills required for their role.
PROTOCOLOS DE LASERTERAPIA NO TRATAMENTO DE MUCOSITE ORAL EM PACIENTES ONCOLÓGICOS PEDIÁTRICOS: UMA REVISÃO INTEGRATIVA
Authors: Oliveira Ana Clara de Godoy Neiva , Lima Eduardo Daniel Carneiro de , Anjos Raíssa Soares dos 
Published: October 2024

Objetivo: Esta revisão integrativa tem como objetivo investigar os protocolos de laserterapia de baixa potência para o tratamento da mucosite oral em pacientes oncológicos pediátricos.Materiais e métodos: A seleção bibliográfica foi realizada por meio de busca online em bases de dados como a Biblioteca Virtual em Saúde (BVS Brasil), Bibliografia Brasileira de Odontologia (BBO), Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS), Medical Literature Analysis and Retrieval System on-line (PubMed), Sistema Online de Busca e Análise de Literatura Médica (MEDLINE). Realizou-se a busca com a utilização dos filtros de idioma, selecionando o inglês e portugês, com um intervalo de tempo de 05 anos (2019-2024), com os seguintes descritores: ´´oral mucositis``, ´´laser therapy`` e ´´children``. Resultados: Dos 5 estudos selecionados cada um foi realizado em um país diferente, são eles: França, Eslovênia, Brasil, Egito e Itália, a duração ocorreu em um intervalo de um ano, aproximadamente, com uma amostra de 14 a 81 pacientes. Em relação ao sexo, foi observado uma variação de 36,25% a 57% do gênero feminino, já o masculino variou entre 43% a 63,75%. No tocante a faixa etária a média da mesma variou de 8 a 12 anos. Quando vamos para comprimento de ondas a variação foi de 635 nm a 980 nm, já a dose de energia teve variação de 2J/cm² a 15,5J/cm², sobre o número de sessões percebeu-se a discrepância entre 4 a 146 sessões . Conclusão: conclui-se que o uso de laser de baixa potência se mostra uma abordagem muito eficaz no manejo da mucosite oral em pacientes oncopediátricos, sendo necessários apenas mais ensaios clínicos randomizados para estabelecer diretrizes mais claras para elucidar qual combinação de comprimento de onda, dose de energia e números de sessões proporcionam melhores resultados.
Impact of a forage legume or nitrogen fertilizer application on ammonia volatilization and nitrous oxide emissions in
Brachiaria
pastures
Authors: Monteiro Rafael Cassador , Santos Camila Almeida dos , Rezende Claudia de Paula , Pereira José Marques , Macedo Robert de Oliveira , Alves Bruno José Rodrigues , Homem Bruno Grossi C. , Urquiaga Segundo , Zaman Mohammad , Boddey Robert Michael 
Published: October 2024

ABSTRACT

The largest proportion of greenhouse gas (GHG) emissions in the Agriculture sector of the Brazilian national GHG inventory is derived from the large (>200 million head) herd of cattle. The greatest contribution to these emissions comes from the enteric methane from cattle, but the direct and indirect emissions of nitrous oxide (N
2
O) from cattle excreta and N fertilizer are responsible for approximately 9 % of all national anthropogenic GHG emissions. Ammonia (NH
3
) can be volatilized from N fertilizer and cattle excreta and deposited in sites remote from the source, constituting an indirect source of N
2
O. This study aimed to determine whether direct N
2
O emissions and NH
3
volatilization from N-fertilized pastures were greater than those derived from a mixed grass-legume pasture without N fertilizer addition. Emissions of N
2
O and NH
3
from excreta and N fertilizer from a Palisade grass (Urochloa brizantha cv. Marandu) monoculture fertilized with 2 × 60 kg N ha
-1
yr
-1
urea were compared to those from a mixed Palisade grass-forage peanut (Arachis pintoi) pasture. Dung and urine were collected from these cattle, and NH
3
losses and N
2
O emissions from the excreta and from N fertilizer were monitored using static chamber techniques. Volatilization of NH
3
and N
2
O emissions were found to be greater from urine than from dung. Ammonia losses from excreta and urea fertilizer were low, not exceeding 6.8, 1.1, and 4.7 % of the N applied as urine, dung, and fertilizer, respectively. The N
2
O emissions showed a tendency to be greater for the urine from the N-fertilized compared to the mixed grass-legume pasture, and the N
2
O emissions from the urine of the N-fertilized pasture ranged from 0.08 to 0.94 % of applied urine N. The N
2
O emission from the N fertilizer was at maximum 0.46 % of the applied N. The direct N
2
O emissions and the loss of NH
3
by volatilization (indirect N
2
O emission) from the excreta of cattle grazing the mixed grass-legume pasture were similar to, or lower than, the grazed grass monoculture fertilized with 120 kg N ha
-1
yr
-1
. As the mixed pasture received no N fertilizer and hence no GHG emission from its manufacture or application, introducing forage peanut to the Urochloa brizantha pastures shows potential to be responsible for lower GHG emissions than the N fertilized grass pasture.
Análisis comparativo de filtros artesanales para tratamiento de aguas grises en áreas rurales
Authors: De Leon Rios Jeanny Elizabeth 
Published: October 2024

Este estudio compara la eficiencia de dos filtros artesanales, usando materiales disponibles en áreas rurales con ausencia de sistema de drenaje, lo que obliga tratar las aguas grises para evitar contaminación. Entonces, el objetivo fue determinar la eficiencia de los filtros en función al tipo de material filtrante, siendo estos: 1) arena, grava, carbón activado, viruta de pino verde; y 2) estopa de coco. La eficiencia de estos se determinó a partir de la medición de la demanda química de oxígeno (DQO), demanda bioquímica de oxígeno (DBO), nitritos, nitratos, fosfatos, color aparente, color real, sólido suspendido, y turbidez en afluente y efluente del filtro. Para este estudio, los filtros se construyeron en una comunidad ubicada en El Paraje de Choquixcabel del municipio de Santa Lucía Utatlán departamento de Sololá, Guatemala. Durante la evaluación se utilizó aguas grises generadas por el lavado de ropa y el agua de la ducha. Durante el estudio se recogieron un total de 12 muestras de afluentes y efluentes. El filtro que presentó mayor eficiencia al 75% en la remoción de parámetros físicos, inorgánicos no metales y orgánicos agregados, fue el de lecho filtrante de viruta de pino verde, aunque su comportamiento no fue constante. Estos filtros presentaron mucha variación con respecto a los resultados, debido al tiempo de almacenamiento del agua en el recipiente del filtro debido al tiempo necesario para la recolección del agua en el hogar.
Comparison of clinical characteristics and prognostic factors in two site-specific categories of ampullary cancer
Authors: Zhang Jing-Zhao , Zhang Zhi-Wei , Guo Xin-Yi , Zhu Deng-Sheng , Huang Xiao-Rui , Cai Ming , Guo Tong , Yu Ya-Hong 
Published: October 2024

BACKGROUND
Ampullary cancer is a relatively rare malignant tumor in the digestive system. Its incidence has increased in recent years. As for now, its biological characteristics have not been fully clarified. Recent studies have primarily focused on the histological classification and genetic changes, but there are fewer investigations into the differences among site-specific subgroups. The clinicopathological characteristics of ampullary cancer occurring in different positions have not been elucidated. Furthermore, the role of adjuvant therapy in the treatment of patients with ampullary cancer remains controversial.
AIM
To study the clinicopathological features of the two site-specific subgroups of ampullary cancer and explore the factors affecting prognosis.
METHODS
A total of 356 patients who met the inclusion and exclusion criteria were enrolled. Patients were divided into ampulla of Vater cancer (AVC) and duodenal papilla cancer (DPC) based on the gross and microscopic findings. Baseline data, admission examination results, and perioperative outcomes were collected and analyzed. The Kaplan-Meier curve was used for survival analysis. Univariate and multivariate analysis was performed to explore the independent risk factors affecting the overall survival (OS) of both groups.
RESULTS
The preoperative total bilirubin level in patients with AVC was significantly higher than those with DPC (P = 0.04). The OS for patients with DPC was 58.90 ± 38.74 months, significantly longer than 44.31 ± 35.90 months for patients with AVC (P < 0.01). The independent risk factors affecting the OS of AVC included: Preoperative albumin level (P = 0.009), total bilirubin level (P = 0.017), and number of positive lymph nodes (P = 0.005). For DPC, risk factors included: Age (P = 0.004), tumor size (P = 0.023), number of positive lymph nodes (P = 0.010) and adjuvant treatment (P = 0.020). Adjuvant therapy significantly improved the OS rate of patients with DPC, but not for those with AVC.
CONCLUSION
Patients with AVC had a shorter OS compared to those with DPC. The prognosis factors and the role of adjuvant therapy of two groups were different.
Impact Of Cawthorne Cooksey Exercise And Strength Training On Gait And Balance Related Impairments In Multiple Sclerosis Patient : A Case Study
Authors: Chaithra BS  , Samuel SE  , Sunil NK  
Published: October 2024

Background: Multiple sclerosis commonly develops between 20 to 40 years of age, however also seen in older populations. It is more common in females than in males. Fatigue, impaired coordination, pain ,blurred vision, weakness in limbs are often the complaints.

Objective: A case study is to provide evidence of the feasibility, acceptance and benefits of Cawthorne Cooksey exercise and strength training in gait and balance related impairments of a multiple sclerosis patient.

Method: 58 years old multiple sclerosis patient was provided an individualised therapy for 3 weeks. Outcome measures included Tinetti Performance Oriented Mobility Assessment (Tinetti POMA) and Timed Up and Go (TUG).

Result: Findings demonstrated the effectiveness of the cawthorne cooksey exercise and strength training for use by multiple sclerosis patient with gait and balance impairments.

Conclusion: The Tinetti POMA Scale and TUG test scores suggested improved gait and balance. However the results were not clinically significant.
Effectiveness Of Visual Feedback Balance Training On Equiboard Versus Traditional Balance Training In Post Stroke Patients- A Comparative Study
Authors: Poonam P. Vaswani  , Jayshree M. Sutaria  
Published: October 2024

Background: A Stroke is classically characterized as a neurological deficit attributed to an acute focal injury of the central nervous system by a vascular cause and is a major cause of disability and death worldwide.(1) Balance problems are thought to be common after stroke and they have been implicated in the poor recovery of activities of daily living and mobility and increased risk of falls.(2) Postural sway for patients with hemiplegia can be twice that of their age matched peers. Many balance training are used but No general physiotherapy approach has proven to be superior for promoting balance recovery from stroke.(3)Novel biofeedback devices based on Virtual reality (VR)technology are now being used for neuromotor rehabilitation. Traditional balance training is based on the automatic repetition of specific movements. These methods can become repetitive and thus reduce the motivation of the patient and adherence to treatment. So the need of my study is to compare the effectiveness of visual feedback balance training on equiboard and traditional balance training in post stroke patients.
Aims and objectives-To study and compare the effectiveness of visual feedback balance training on equiboard versus traditional balance training in post stroke patients.
Methodology- 30 patients with stroke were equally divided into two groups. patients in group A received the conventional physiotherapy while the patients in group B received visual feedback balance training on equiboard. All the subjects were treated for 1 month, 5 days a week. BBS-Berg Balance Scale and step test was used as the outcome measure at the beginning and end of study.
Results-Results showed significant improvement within both the groups for both the outcome measure(p,0.05), while there was no significant difference between two groups in BBS(p>0.5), but there was significant difference in the step test of experimental group(p<0.5)
Conclusion-It can be concluded that visual feedback balance training is more effective than the traditional balance training alone in stroke patients.
KEMPELEN'S CHESS AUTOMATON AS A REFLECTION OF THE PHENOMENON OF ADVENTURISM OF THE ENLIGHTENMENT
Authors: Пилавов Георгий Шаликович 
Published: October 2024

В статье изучается феномен авантюристов эпохи Просвещения. Показано, что шахматный автомат Кемпелена отображал данное явление в пространстве шахмат.
The article examines the phenomenon of adventurers of the Enlightenment era. It is shown that the Kempelen chess automaton reflected this phenomenon in the space of chess.
PERSONALITY SIMPHONY VERSUS PERSONALISM (MODERN CORPORATION SPIRIT)
Authors: Печерских Николай Александрович 
Published: October 2024

Современный мир есть мир не только индивидов, но и корпораций. Те и другие понимают, мыслят и чуствуют, но по разному. Корпоративный разум парадигматичен, а не логичен. Корпоративная культура многостороння и сложна. Неисчерпаемое будущее требует от корпорации стать личностной, требует взаимного трансцендирования с индивидами, и взаимной открытости с обществом.
Contemporary world is world of individuals and corporations as well. Both mean, think and feel, but in defferent way. Corporate meaning is paradigmatic and not logical. The corporate culture is multilateral and complex. Inexhaustible future challenge contemporary corporation to became personal, to transcende mutually with individuals and to open mutually with society.
DEVELOPMENT OF A QUESTIONNAIRE BASED ON THE UNIVERSAL MODEL OF WORK MOTIVATION
Authors: Карпов Алексей Борисович 
Published: October 2024

В статье обсуждается растущая в последнее время необходимость создания современного и актуального инструмента оценки трудовой мотивации. На базе универсальной модели трудовой мотивации - оригинальной разработки, автор представляет опросник, состоящий из трех субтестов, в которых оцениваются факторы трудовой мотивации, ведущие мотивы, а также удовлетворенность работников работодателем.
The article discusses the recently growing need to create a modern and relevant methodic for assessing work motivation. Based on the universal model of work motivation - an original development, the author presents a questionnaire consisting of three subtests that assess factors of work motivation, leading motives, as well as employee satisfaction with the employer.