bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmentation of the Nasal Dorsum Using the Multistrip Autologous Cartilage Technique
Authors: Liu Liqiang , Bu Zhaoyun , Fan Jincai , Tian Jia , Gan Cheng , Yang Zengjie , Jiao Hu 
Published: August 2017

Summary:
Nasal augmentation is a popular modern technique requested by many Asian people. There are two kinds of autologous cartilage used to augment the nose at present: carved as a monobloc or diced into pieces. Each approach has its pros and cons. The authors performed their surgical technique on a group of 28 patients. Twenty of these patients had undergone rhinoplasties performed before referral to our hospital; eight of these patients had undergone a primary rhinoplasty. Bilateral conchal, nasal septum, or rib cartilage was harvested; deep temporal fascia or abdominal muscle fascia to be prepared for packing stripped cartilage was also removed at this time. The cartilage was placed on a plastic cutting board and cut into strips with a transverse section of 1 × 1 mm. Then, these strips were packed and covered by fascia to form the grafts. The median follow-up was 23 months (range, 12 to 48 months). Twenty-two patients were satisfied with their augmented noses. Through examinations, biopsies, and magnetic resonance imaging scans, less resorption was observed with the multistrip autologous cartilage technique. Junctional stepoffs, excessive prominence, and slanting grafts occurred in three patients, two of whom had revisions. Using multistrip autologous cartilage grafts is an easier method to perform and could be another alternative technique for augmentative and reconstructive rhinoplasties.
Evaluation of Protraction Face-Mask Therapy on the Craniofacial and Upper Airway Morphology in Unilateral Cleft Lip and Palate
Authors: Keçik Defne 
Published: August 2017

Introduction:
The aim of the authors’ study was to evaluate the effects of protraction face-mask therapy on the craniofacial and upper airway morphology in patients with unilateral cleft lip and palate (UCLP).

Methods:
Twenty-three growing UCLP patients (mean age: 8.3 + 2.4) were enrolled in the study group. Protraction face-mask in combination with Hyrax appliance was applied for the correction of anterior crossbite and maxillary insufficiency. Twenty-six patients with maxillary retrusion (mean age: 8.1 + 2.5) were evaluated as the control group. The pharyngeal airway morphology was assessed via the area measurements of upper airway structures on the lateral cephalometric radiographs.

Results:
The upper airway morphology was similar compared with the control group subjects at the beginning of the treatment. The pharyngeal airway area was increased significantly following the maxillary expansion and protraction. Nasopharyngeal area increased and the oropharyngeal area decreased significantly. There was an increase in the sagittal and vertical dimensions after the protraction therapy.

Conclusion:
The pharyngeal morphology in both UCLP patients and control group patients was similarly improved with the protraction face-mask therapy.
Neuro-Ophthalmic Manifestations of Pediatric Neurodegenerative Disease
Authors: Heidary Gena 
Published: August 2017

Abstract:
The topic of pediatric neurodegenerative disease is broad and ever expanding. Children who suffer from neurodegenerative disease often have concomitant visual dysfunction. Neuro-ophthalmologists may become involved in clinical care to identify corroborating eye findings when a specific condition is suspected, to monitor for disease progression, and in some cases, to assess treatment efficacy. Ophthalmic findings also may be the harbinger of a neurodegenerative process so a keen awareness of the possible manifestations of these conditions is important. The purpose of this review is to highlight common examples of the neuro-ophthalmic manifestations of pediatric neurodegenerative disease using a case-based approach in an effort to provide a framework for approaching these complex patients.
Committed Hemopoietic Progenitors, Not Stem Cells, are the Principal Responders to Hox Gene Transduction
Authors: Lim Harvey , Janmohamed Salima , Benveniste Patricia , Herrington Robert , Barbara Mary , Frelin Catherine , Hyam Deborah , Paige Christopher J. , Zuñiga-Pflücker Juan-Carlos , Stocking Carol , Krosl Jana , Sauvageau Guy , Iscove Norman N 
Published: August 2017

ABSTRACTAs hemopoietic stem cells differentiate, their proliferative lifespan shortens by unknown mechanisms. Homeobox cluster (Hox) genes have been implicated by their enhancement of self-renewal when transduced into hemopoietic cells, but gene deletions have been inconclusive because of functional redundancy. Here we enforced HOXB4 expression in purified precursor stages, and compared responses of early stages expressing the endogenous genes with later stages that did not. Contrary to the prevalent view that transduced Hox genes enhance the self-renewal of hemopoietic stem cells, stem cells or their multipotent progeny expressing the endogenous genes showed little response. Instead, immortalization, extensive self-renewal and acquired reconstituting potential occurred in committed erythroid and myeloid progenitors where the endogenous genes were shutting down. The results change our understanding of the stages affected by exogenous HOX proteins and point to shutdown of the endogenous genes as a principal determinant of the shortened clonal lifespans of committed progenitor cells.
CBF-1 promotes the establishment and maintenance of HIV latency by recruiting Polycomb repressive complexes, PRC1 and PRC2, at HIV LTR
Authors: Zicari Sonia , Farley Kalamo , Sun Lin , Spurr Liam , Dragon Andrea , Bukrinsky Michael , Simon Gary , Chauhan Ashok , Tyagi Mudit 
Published: August 2017

AbstractThe C-promoter binding factor-1 (CBF-1) is a potent and specific inhibitor of the HIV-1 LTR promoter. Here we demonstrate that the knockdown of endogenous CBF-1 in latently infected primary CD4+ T cells, using specific small hairpin RNAs (shRNA), resulted in the reactivation of latent HIV proviruses. Chromatin immunoprecipitation (ChIP) assays using latently infected primary T cells and Jurkat T-cell lines demonstrated that CBF-1 induces the establishment and maintenance of HIV latency by recruiting Polycomb Group (PcG/PRC) corepressor complexes or Polycomb repressive complexes 1 and 2 (PRC1 and PRC2). Knockdown of CBF-1 resulted in the dissociation of PRCs corepressor complexes enhancing the recruitment of RNA polymerase II (RNAP II) at HIV LTR. Knockdown of certain components of PRC1 and PRC2 also led to the reactivation of latent proviruses. Similarly, treatment of latently infected primary CD4+ T cells with the EZH2 inhibitor, 3-deazaneplanocin A (DZNep), led to their reactivation.
Synthetic 5’ UTRs can either up- or down-regulate expression upon RBP binding
Authors: Katz Noa , Cohen Roni , Solomon Oz , Kaufmann Beate , Atar Orna , Yakhini Zohar , Goldberg Sarah , Amit Roee 
Published: August 2017

SUMMARYThe construction of complex gene regulatory networks requires both inhibitory and up-regulatory modules. However, the vast majority of RNA-based regulatory “parts” are inhibitory. Using a synthetic biology approach combined with SHAPE-Seq, we explored the regulatory effect of RBP-RNA interactions in bacterial 5’-UTRs. By positioning a library of RNA hairpins upstream of a reporter gene and co-expressing them with the matching RBP, we observed a set of regulatory responses, including translational stimulation, translational repression, and cooperative behavior. Our combined approach revealed three distinct statesin-vivo: in the absence of RBPs, the RNA molecules can be found either in a molten state that is amenable to translation, or a structured phase that inhibits translation. In the presence of RBPs, the RNA molecules are in a semi-structured phase with partial translational capacity. Our work provides new insight into RBP-based regulation and a blueprint for designing complete gene regulatory circuits at the post-transcriptional level.
Assessing eRNAs associated with a cytokine-sensing mammary super-enhancer
Authors: Wang Chaochen , Kuhns Tyler , Reinbold Christian , Willi Michaela , Hennighausen Lothar 
Published: August 2017

AbstractEnhancers are transcription factor platforms that also bind RNA polymerase II and generate enhancer RNAs (eRNA). Although eRNAs have been suggested as predictors of enhancer activities and possibly key components facilitating transcription, there is little genetic evidence to support this. We address the biology of eRNAs in vivoand investigate eRNA patterns, expression levels and possible functions within a mammary-specific super-enhancer that is composed of three units with distinct transcriptional capacities. We show that eRNA levels do not correspond with the activities of their respective enhancer units. However, changes in eRNA expression upon deletion of individual enhancer units reflect the change in overall super-enhancer activity. These data provide genetic evidence that eRNA levels are not a reliable readout of individual enhancers, but they predict super-enhancer activity in the absence of constituent elements.
Formulation of reduced sugar herbal ice cream using lemongrass or ginger extract
Authors: Chamchan Rungrat , Sinchaipanit Pornrat , Disnil Sasapin , Jittinandana Sitima , Nitithamyong Anadi , On-nom Nattira 
Published: August 2017

Purpose
Ice cream is one of the popular sweet throughout the world. However, it contains high fat and sugar but lacks natural antioxidants. Several herbs in Thailand which are traditionally used as food ingredients show high antioxidant properties such as ginger and lemongrass. Therefore, the purpose of this paper is to develop reduced sugar herbal ice cream using lemongrass and ginger extract.

Design/methodology/approach
Two ice cream formulas were prepared by using the lemongrass or ginger extract at the levels of 10, 15 and 20 percent (w/w), respectively. Moreover, xylitol was added as a substituted sugar at 80, 90 and 100 percent (w/w). Sensory evaluation was conducted by nine-point hedonic scale. Moreover, the physical, chemical and microbiological properties of the final ice cream product were determined by comparing with the control formula.

Findings
Based on the sensory evaluation, the two herbal ice cream formulas (15 percent lemongrass or ginger extract) with 90 percent xylitol replacement have the highest overall acceptability score of 7.28 and 7.44 (like moderately), respectively. The viscosity, overrun value and hardness of the reduced sugar herbal ice cream were not significantly different as compared to control formula (p=0.05). The chemical composition analysis showed that the total sugar of the product decreased by 65 percent. Moreover, antioxidant activities of herbal ice creams were higher than the control formula. The number of total bacteria of reduced sugar herbal ice cream was less than 10 CFU/mL.

Originality/value
The reduced sugar consumption is useful for lowering the risk of non-communicable diseases (NCDs), especially diabetes mellitus. This paper presented the reduced sugar herbal ice cream formulas with high antioxidant activity. Therefore, these data could be the prototype in order to develop herbal and healthy ice cream product.
Microencapsulation of natural vanilla (Vanilla planifolia) extract in β-cyclodextrin by using kneading method
Authors: Krasaekoopt Wunwisa , Jongyin Ampapan 
Published: August 2017

Purpose
The purpose of this paper is to encapsulate vanilla extract by using inclusion complex of ß-cyclodextrin and also to investigate the qualities of the encapsulated powder in terms of vanillin content, moisture content, and stability under accelerated condition.

Design/methodology/approach
A randomized block and factorial 3×3 experimental designs with three replications were used for the studies of solvent extraction, microencapsulation of natural vanilla extract and stability of microencapsulated vanilla powder.

Findings
Ethanol concentration and ratio of vanilla to ethanol had positive effects on vanillin content. The extraction with 55 percent ethanol and the ratio of vanilla pods to ethanol as 1:4 provided the highest vanillin content of 341.23 mg/100 mL of the extract. The amount of vanilla extract and kneading time gave significant (p<0.05) effect on the microencapsulation efficiency (ME). The greatest ME found was 94.50 percent when 9 percent vanilla extract and 10 min of kneading time were used. The interaction of temperature and water activity gave significant effect on the second-order kinetic reaction of encapsulated vanilla powder (p<0.05).The most suitable condition of storage was 35°C with aw of 0.64, providing the kinetic constant (k) of 0.0024, and correlation coefficient (R2) of 0.92 with thalf-life of 4.54 weeks.

Originality/value
This study provides the most suitable condition for natural vanilla extraction and microencapsulation as well as storage stability for natural vanilla powder production using the third grade vanilla pods grown at Royal Project, Khun Wang Center, Chiang Mai, Thailand.
Analysing the relationship between information-seeking and help-seeking behaviours in a digital library
Authors: Zerehsaz Mohammad 
Published: August 2017

Purpose
This paper aims to investigate the help-seeking behaviour of users during their information-seeking in a digital library, studying the kind of help-seeking situations, help requests and using help resources with different interactive levels. For this purpose, users’ help-seeking behaviour (postgraduate students at Ferdowsi University of Mashhad) was investigated based on different stages of Marchionini’s adapted model.

Design/methodology/approach
This research was performed using the mixed method. In total, 38 postgraduate students at Ferdowsi University were selected by Stratified Purposive Sampling method as samples. Selecting a digital library based on considered factors, preparing help resources and designing research scenario were made as the preparation stages of performing the study. The tools used for collecting and analysing data were questionnaires, think aloud protocol and Morae software.

Findings
Some of the considerable results of this research were recording the help-seeking signs in all four main stages of the adapted information-seeking model. However, in the search stage, in which a user enters the search process practically, the need for help-seeking was recorded more than it in other stages. Results also confirmed that most help requests by users were for executive help which were rooted in users’ knowledge shortcomings and their passivity in help-seeking process. Because of the flexibility and speed of providing responses, participants also tended to interact with more interactive and flexible help resources and assessed this interaction more useful.

Originality/value
According to the findings of this research, the adapted information-seeking model used in this study was completed, and a theoretical model for information-seeking in a digital library was suggested. In this model, help-seeking is considered as a supportive and complementary behaviour for information-seeking behaviour which begins in help-seeking situations and continues to solve problems in these situations.
Estimation of P(X<Y) for generalized half logistic distribution based on Type-II censored data
Authors: Roy Soumya , Pradhan Biswabrata , Gijo E.V. 
Published: August 2017

Purpose
The purpose of this paper is to compare various methods of estimation of P(X<Y) based on Type-II censored data, where X and Y represent a quality characteristic of interest for two groups.

Design/methodology/approach
This paper assumes that both X and Y are independently distributed generalized half logistic random variables. The maximum likelihood estimator and the uniformly minimum variance unbiased estimator of R are obtained based on Type-II censored data. An exact 95 percent maximum likelihood estimate-based confidence interval for R is also provided. Next, various Bayesian point and interval estimators are obtained using both the subjective and non-informative priors. A real life data set is analyzed for illustration.

Findings
The performance of various point and interval estimators is judged through a detailed simulation study. The finite sample properties of the estimators are found to be satisfactory. It is observed that the posterior mean marginally outperform other estimators with respect to the mean squared error even under the non-informative prior.

Originality/value
The proposed methodology can be used for comparing two groups with respect to a suitable quality characteristic of interest. It can also be applied for estimation of the stress-strength reliability, which is of particular interest to the reliability engineers.
Facebook in the low-cost fashion sector: the case of Primark
Authors: Arriaga Josep Lluis Del Olmo , Andreu Domingo David , Berlanga Silvente Vanesa 
Published: August 2017

Purpose
The purpose of this paper is to analyse the interaction between fashion brands and consumers on social network sites. More precisely, the goal is to assess the relationship that is established between the low-cost fashion company Primark and followers of the brand on the Facebook social network in Spain, and to evaluate the brand’s use of consumer passion through this social network.

Design/methodology/approach
The fieldwork for this research was conducted over September-October 2015, which coincided with the final stages in the sales and the start of the autumn-winter 2015 season. The methodology was based on a daily study of all Primark publications and user interactions with the brand on Facebook.

Findings
The results of this study show that there is some engagement between Facebook users and Primark. However, the company does not respond to this user interaction, thereby missing opportunities in the field of consumer passion.

Originality/value
Until now, research into the interaction of fashion brands with users of the social networks has focused mainly on the luxury sector. This study makes an important contribution to research into the interaction between a low-cost fashion brand and users of social network sites. Primark was chosen as the focus of this case study because the brand has become a model since it broke into the mature Spanish fashion market.
Media and sustainable apparel buying intention
Authors: de Lenne Orpha , Vandenbosch Laura 
Published: August 2017

Purpose
Using the theory of planned behavior, the purpose of this paper is to examine the relationships between different types of media and the intention to buy sustainable apparel and test whether attitudes, social norms, and self-efficacy beliefs may explain these relationships.

Design/methodology/approach
A cross-sectional survey study was conducted among 681 young adults (18-26 years old).

Findings
Exposure to social media content of sustainable organizations, eco-activists, and sustainable apparel brands, and social media content of fashion bloggers and fast fashion brands predicted respondents’ attitudes, descriptive and subjective norms, and self-efficacy beliefs regarding buying sustainable apparel. In turn, attitudes, descriptive norms, and self-efficacy beliefs predicted the intention to buy sustainable apparel. Fashion magazines predicted the intention through self-efficacy. Specialized magazines did not predict the intention to buy sustainable apparel.

Research limitations/implications
Results should be generalized with caution as the current study relied on a convenience sample of young adults. The cross-sectional study design limits the ability to draw conclusions regarding causality. Actual behavior was not addressed and needs to be included in further research.

Practical implications
The present study hints at the importance of social media to affect young consumers’ intentions to buy sustainable apparel. Sustainable apparel brands should consider attracting more young social media users to their social media pages.

Originality/value
This study is one of the first to examine the potential of different media to promote sustainable apparel buying intention.
Corporate social responsibility and behavioral intention: the moderator effect of contextual factors
Authors: Al Jarah Ahmad , Emeagwali Okechukwu Lawrence 
Published: August 2017

Purpose
The purpose of this paper is to examine the impact of corporate social responsibility (CSR) on the behavioral intention (BI) of customers (e.g. repurchase/revisit intention, spread word of mouth, loyalty, willingness to pay).

Design/methodology/approach
A quantitative meta-analysis of 37 articles (n = 34,942) was conducted to determine the effect sizes of the relationship between CSR and BI of the customer. Furthermore, two kinds of contextual factors (environmental context and industry type) have been investigated as potential moderators between CSR and BI.

Findings
Meta-analysis suggests that the positive relationship between CSR and BI is well-established and has a large effect size (r = 0.42). Individually, the repurchase/revisit intention was the most affected by CSR (r = 47) followed by loyalty intention (r = 0.41) where both word of mouth and willingness-to-pay intentions were less affected by CSR (r = 0.38, r = 0.37, respectively). Moreover, the result of meta-regression shows that both environmental context and industry type do not moderate the relationship between CSR and BI.

Originality/value
The originality of this paper comes from presenting a summary of the direction of research on primary relationship between CSR and BI, as no prior meta-analysis on the primary relationship has been conducted till date (to the best of the authors’ knowledge).
Human resources disclosure among companies in Czechia
Authors: Petera Petr , Wagner Jaroslav 
Published: August 2017

Purpose
The purpose of the paper is to investigate voluntary human resources disclosure (hereinafter referred to as “HR disclosure”) by the largest companies domiciled in Czechia. The key research questions are: What is the quantity of disclosure on various topics related to HR? Is there a significant difference in the quantity of HR disclosure between companies? Which factors influence the quantity of HR disclosure?

Design/methodology/approach
A quantitative content analysis (CA) of annual reports of the 50 largest companies domiciled in Czechia was used. An established coding scheme is used to code annual reports, and subsequently, various statistical methods (descriptive statistics, correlation analysis, multiple linear regression) are used to answer the key research questions.

Findings
Primarily, social information is reported (what a company does for its employees) as information on the contribution of employees to the company’s value is rudimentary. Secondly, there is a significant difference in the quantity of HR disclosure between companies. Finally, the findings of the regression analysis confirm the impact of presence on the stock exchange and size and on the quantity of HR disclosure.

Research limitations/implications
The annual reports of 50 companies from one country are analysed. The study provides a basis for further research.

Practical implications
The findings of this study may inspire companies to improve their HR disclosure, while policymakers should consider imposing more concrete demands on HR disclosure.

Originality/value
Quantitative CA research into the HR disclosure of companies domiciled in Czechia is nearly non-existent. This study fills this gap.