bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring UK older adults’ dietary fibre consumption habits and associated factors: a national diet and nutrition survey perspective
Authors: Norton Victoria , Kaimila Yankho , Lovegrove Julie A. , Lignou Stella 
Published: September 2024

AbstractThe UK population is living longer; therefore, promoting healthy ageing via positive nutrition could have widespread public health implications. Moreover, dietary fibre intake is associated with health benefits; however, intake is below UK recommendations (30 g/d). Utilising national dietary survey data can provide up-to-date information on a large representative cohort of UK older adults, so that tailored solutions can be developed in the future. This study used cross-sectional data from the National Diet and Nutrition Survey (years 2008–2009 to 2018–2019) for older adults’ (n 1863; 65–96 years) dietary fibre intake (three-to-four-day food diaries), top ten dietary fibre-rich foods, associated factors (demographics, dietary/lifestyle habits) and various health outcomes (anthropometric, blood and urine). Mean dietary fibre intake was 18·3 g/d (range: 2·9–55·1 g/d); therefore, below the UK dietary recommendations, with compliance at 5·7 %. In addition, there were five significant associations (P < 0·05) related to lower dietary fibre intake such as increasing age group, without own natural teeth, impaired chewing ability, lower education leaving age and poor general health. Older adults’ key foods containing dietary fibre were mainly based on convenience such as baked beans, bread and potatoes. Positively, higher dietary fibre consumption was significantly associated (P = 0·007) with reduced diastolic blood pressure. In summary, the benefits of dietary fibre consumption were identified in terms of health outcomes and oral health were key modulators of intake. Future work should focus on a life course approach and the role of food reformulation to help increase dietary fibre intake.
Expression profiling of Spodoptera exigua (Lepidoptera: Noctuidae) microRNAs and microRNA core genes by Bacillus thuringiensis GS57 infection
Authors: Gao Bo , Ji Yu-Jie , Zhao Dan , Zhang Lu , Wu Han , Xie Yi-Fan , Shi Qiu-Yu , Guo Wei 
Published: September 2024

AbstractMicroRNAs (miRNAs) are endogenous, non-coding RNAs, which are functional in a variety of biological processes through post-transcriptional regulation of gene expression. However, the role of miRNAs in the interaction between Bacillus thuringiensis and insects remains unclear. In this study, small RNA libraries were constructed for B. thuringiensis-infected (Bt) and uninfected (CK) Spodoptera exigua larvae (treated with double-distilled water) using Illumina sequencing. Utilising the miRDeep2 and Randfold, a total of 233 known and 726 novel miRNAs were identified, among which 16 up-regulated and 34 down-regulated differentially expressed (DE) miRNAs were identified compared to the CK. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that potential target genes of DE miRNAs were associated with ABC transporters, fatty acid metabolism and MAPK signalling pathway which are related to the development, reproduction and immunity. Moreover, two miRNA core genes, SeDicer1 and SeAgo1 were identified. The phylogenetic tree showed that lepidopteran Dicer1 clustered into one branch, with SeDicer1 in the position closest to Spodoptera litura Dicer1. A similar phylogenetic relationship was observed in the Ago1 protein. Expression of SeDicer1 increased at 72 h post infection (hpi) with B. thuringiensis; however, expression of SeDicer1 and SeAgo1 decreased at 96 hpi. The RNAi results showed that the knockdown of SeDicer1 directly caused the down-regulation of miRNAs and promoted the mortality of S. exigua infected by B. thuringiensis GS57. In conclusion, our study is crucial to understand the relationship between miRNAs and various biological processes caused by B. thuringiensis infection, and develop an integrated pest management strategy for S. exigua via miRNAs.
A Daughter of Saint Catherine
Authors: Catherine Mary 
Published: September 2024

On March the 25th 1347, in the Fontebranda, Siena, were born to Jacomo
Benincasa and his wife Lapa, twin girls, the last of a family of twenty
five. One, Giovanna, died shortly after birth, the other, Catherine, lived
to become the glory of her city.
On January the 23rd 1802, over four and a half centuries later, in Saint
Giles Rookery, one of London's slums, was born to Edmund Hallahan and his
wife, Catherine, Margaret, the only child of povertystricken parents, but
who grew up to be one of the very faithful followers of the dyer's
daughter.
Both belonged to the people, but whereas one was the daughter of
well-to-do parents, the other was the child of a casual—a very
casual—labourer. Catherine died at the age of thirty three on April the
29th. Margaret doubled the life's span of her prototype and died on May the
n t h at the age of sixty six.
O Sapientia
Authors: Evans Illtud 
Published: September 2024

Vergente mundi vespere,

Uti sponsus de thalamo,

Egressus honestissima

Virginis matris clausula.

The coming of Christ our Lord is an end and a beginning: an end to the
world of waiting, of the promise that is to be fulfilled; a beginning of the
world of the new creation that springs from his birth in human
flesh.
It is at Vespers, at the evening prayer of the Church, that his coming
is solemnly commemorated on the seven days before Christmas. Each evening he
is named and praised and invoked in the Magnificat antiphon, gracing the
words of his Mother, ‘My soul magnifies the Lord; my spirit has found joy in
God, who is my Saviour’.
O Sapientia. The first evening names our Lord
as Wisdom, ‘coming forth from the mouth of the Most High, reaching from one
end to another, ordering all things mightily and with sweetness: come to
teach us the way of prudence. The pattern for each of the seven antiphons is
the same: the naming of the Lord who is to come, the expansion of that name
and then the supplication.
The distribution of non, nenny and non fait in Pre-Classical and Classical French
Authors: Saiz-Sánchez Marta 
Published: September 2024

AbstractThe aim of this study is to track the evolution in the use of the markers nenny, non + verb (non fait ‘no, it doesn’t’) and non in its absolute use between the middle of the 15th century and the end of the 18th. In Middle French, non already covers all the uses of the old markers nenny and non fait, but it remains in the minority. In Pre-Classical French (1550–1650), the frequency of nenny and non fait decreases considerably and, in Classical French (1650–1789), they become archaic. In the mid-17th century, non definitively assumes the functions of the medieval markers, which disappeared. The analysis of the temporal distribution of these markers helps to date the transition from ancient to modern uses. Several studies of phonetic, morphological and syntactic phenomena have also aimed to date the turning point between the medieval and the “classical” language, which occurs during the so-called “pre-classical” period. This research also seeks to contribute to the debate on the position of the boundary between Pre-Classical and Classical French on the basis of pragmatic criteria. The results support placing this boundary within the decade 1620–1630, as other studies did for morphosyntactic phenomena.
Morphological evaluation for the narrowest section of the patent ductus arteriosus in infants by CT: a crucial point for device closure
Authors: Fukushima Yosuke , Nakagawa Naomi , Kamada Masahiro , Okamoto Kengo , Uemasu Hitoshi , Kataoka Koichi 
Published: September 2024

AbstractBackground:The minimum diameter of the patent ductus arteriosus measured in the lateral angiographic view is usually used to determine the device size. Sometimes the device can be easily removed from the patent ductus arteriosus, even if it appears to be the optimum size.Methods:From 2016 to 2021, 29 patients who underwent contrast-enhanced CT prior to patent ductus arteriosus closure included. Morphological evaluation of the narrowest part of the patent ductus arteriosus was performed on contrast-enhanced CT. We also examined whether there were differences in morphology depended on Krichenko classification, age, and the diameter of the narrowest portion of the patent ductus arteriosus.Results:At the time of treatment, the median age was 4.8 (range, 1–52) months, and the median weight was 5.0 (2.5–12.7) kg. The median minimum vertical diameter of patent ductus arteriosus was 2.9 (1.6–6.6) mm. The narrowest patent ductus arteriosus part in the contrast CT imaging showed horizontal-to-vertical diameter ratios in the range of 1.0–1.7, with no case where the vertical diameter was larger than the horizontal diameter. The median horizontal-to-vertical diameter ratio by Krichenko type was: A, 1.22; C, 1.29; E, 1.62(p = 0.017). When classifying the patients into a group aged under six months (n = 21) and a group aged six months or older (n = 8), the respective median horizontal-to-vertical diameter ratio was 1.34 and 1.15 (p = 0.027). The vertical patent ductus arteriosus diameter was not correlated with the elliptical shape.Conclusions:Most patent ductus arteriosus cases have a horizontally oriented elliptical shape in this study. This characteristic showed high reproducibility and is important information that angiography cannot evaluate.
A REE Inverse Model From Bulk Distribution Coefficients and Boundary Conditions: Results for Shield and Rejuvenated Stage Hawaiian Volcanoes
Authors: Carr M. J. , Feigenson M. D. , Gazel E. 
Published: September 2024

AbstractA major challenge in mantle geochemistry is determining the source composition and melt fraction involved in melting. We provide a new Rare‐Earth Element (REE) inverse model that provides source concentration, source and melt mineral modes, and melt fraction based on the difference between separate determinations of bulk distribution coefficients and constrained by boundary conditions. An analytical inverse of the batch melting equation provides expressions for source, , and bulk distribution coefficient of the mantle, , with two unknowns, the initial concentration of La in the mantle, , and Pi, the bulk distribution coefficient of the melt. We traverse through a range of steps and examine thousands of melt modes, Pi, at each step. Thousands of trial melt modes fail by generating that are inconsistent with partition coefficients. Many surviving trials cannot be inverted to estimate a mantle mode. Other boundary conditions eliminate even more trials. Surviving trials are ordered by the difference between calculated from the REE data of a lava suite and calculated from partition coefficients and mantle mode. We select the solution with the closest fit that passes all the boundary conditions. We tested our new model with lava suites from Hawaii where different lines of evidence suggest that they melted from different mantle sources, Mauna Kea representing shield‐stage lava and submarine Kiekie representing rejuvenated stage lava. Our inverse determination of mantle composition and melting parameters was consistent with earlier models based on assumptions of HREE composition.
Variation of Molecular Ions in the Inner Magnetosphere Observed by the Arase Satellite
Authors: Nagatani A. , Miyoshi Y. , Asamura K. , Kistler L. M. , Nakamura S. , Seki K. , Ogawa Y. , Shinohara I. 
Published: September 2024

AbstractWe analyzed time‐of‐flight (TOF) data from the Arase satellite to investigate temporal variations of the molecular ion group (O2+, NO+, and N2+) at 19.2 keV/q in the inner magnetosphere for 6 years from the solar declining to rising phase. The molecular ions counts were estimated by subtracting the background contamination of oxygen counts. While the number of clear molecular ion events was small, the estimated counts exhibited good correlation with the solar wind dynamic pressure and SYM‐H index. Long‐term variations of the molecular ions differed from those of counts of the O+ and N+ group. Additionally, we discuss the importance of the solar wind dynamic pressure in causing variations of molecular ions in the inner magnetosphere.
Crossing epigenetic frontiers: the intersection of novel histone modifications and diseases
Authors: Yao Weiyi , Hu Xinting , Wang Xin 
Published: September 2024

AbstractHistone post-translational modifications (HPTMs), as one of the core mechanisms of epigenetic regulation, are garnering increasing attention due to their close association with the onset and progression of diseases and their potential as targeted therapeutic agents. Advances in high-throughput molecular tools and the abundance of bioinformatics data have led to the discovery of novel HPTMs which similarly affect gene expression, metabolism, and chromatin structure. Furthermore, a growing body of research has demonstrated that novel histone modifications also play crucial roles in the development and progression of various diseases, including various cancers, cardiovascular diseases, infectious diseases, psychiatric disorders, and reproductive system diseases. This review defines nine novel histone modifications: lactylation, citrullination, crotonylation, succinylation, SUMOylation, propionylation, butyrylation, 2-hydroxyisobutyrylation, and 2-hydroxybutyrylation. It comprehensively introduces the modification processes of these nine novel HPTMs, their roles in transcription, replication, DNA repair and recombination, metabolism, and chromatin structure, as well as their involvement in promoting the occurrence and development of various diseases and their clinical applications as therapeutic targets and potential biomarkers. Moreover, this review provides a detailed overview of novel HPTM inhibitors targeting various targets and their emerging strategies in the treatment of multiple diseases while offering insights into their future development prospects and challenges. Additionally, we briefly introduce novel epigenetic research techniques and their applications in the field of novel HPTM research.
Blockade of CD73 potentiates radiotherapy antitumor immunity and abscopal effects via STING pathway
Authors: An Ran , Wu Chao , Tang Cunyu , Zhang Chen , Han Feiru , Xu Zeen , Zou Yiping , Wang Jun , Yuan Zhiyong , Jiang Shengpeng , Liu Lijie , Huang Chongbiao , Tao Zhen 
Published: September 2024

AbstractRadiotherapy (RT) is a crucial treatment for colorectal cancer (CRC) patients, but it often fails to induce systemic antitumor immunity. CD73, an immunomodulatory factor, is upregulated after RT and associated with poor prognosis in CRC patients. This study aims to elucidate the mechanisms driving RT-induced CD73 upregulation in CRC and investigate how combining RT with CD73 blockade stimulates immune responses and induces abscopal effects. Findings revealed that RT-induced CD73 upregulation is mediated by the ataxia telangiectasia and Rad3-related (ATR) pathway and correlated with RT tolerance, as demonstrated through flow cytometry, immunofluorescence, and Western Blotting. Using flow cytometry and multicolor immunofluorescence, experiments demonstrated that in CRC subcutaneous tumor models, combination therapy reduces the infiltration of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and regulatory T cells (Tregs) while increasing dendritic cells (DCs) and CD8 + T cells, resulting in superior antitumor responses. Additionally, results from flow cytometry, Western Blot, and RNA sequencing demonstrated that combination therapy enhances the antigen-presenting ability of DCs and activates tumor antigen-specific CD8 + T cells, improving their function and delaying their depletion. The activation of the cGAS-STING and IFN-I pathways is crucial for this effect. In summary, the integration of RT with CD73 blockade effectively reverses the immunosuppressive TME and invigorates CD8 + T cell-driven, specific antitumor immune responses. These insights shed fresh light on the mechanisms governing the synergistic modulation of immunity by RT and CD73 blockade in CRC, offering promising avenues for the advancement of therapeutic strategies against CRC.
Epigallocatechin gallate enhances sympathetic heart rate variability and decreases blood pressure in obese subjects: a randomized control trial
Authors: Wilasrusmee Kittikorn Tommy , Sitticharoon Chantacha , Keadkraichaiwat Issarawan , Maikaew Pailin , Pongwattanapakin Kitchaya , Chatree Saimai , Sririwichitchai Rungnapa , Churintaraphan Malika 
Published: September 2024

AbstractThis study aimed to investigate effects of epigallocatechin gallate (EGCG) on blood pressure (BP) and autonomic nervous system, indicated by 5-min heart rate variability (HRV) measurement in obese subjects, and determine correlations of BP with metabolic factors. In a double-blind, randomized controlled trial, obese subjects (n = 30) were randomly allocated to receive 150 mg EGCG (n = 15) or placebo (n = 15) twice a day without dietary restrictions. After 8-week EGCG treatment, systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) significantly decreased, while the low-frequency (LF) to high-frequency power (HF) ratio (LF/HF ratio) significantly increased (P < 0.05 all), indicating a shift toward sympathetic dominance, either directly or indirectly after BP lowering. SBP had positive correlations with obesity parameters, leptin, insulin, and insulin resistance but had a negative correlation with insulin sensitivity. DBP was positively correlated with age and HF in normalized unit, but negatively correlated with height and LF in ms2. High-density lipoprotein cholesterol (HDL-C) was negatively correlated with SBP, DBP, and MAP reflecting its protective effect against elevated BP. In conclusion, the 8-week EGCG treatment decreased BP and increased the LF/HF ratio, reflecting increased sympathetic activity, either a direct EGCG effect or an indirect compensatory response following BP reduction.
Targeted sulfur(VI) fluoride exchange-mediated covalent modification of a tyrosine residue in the catalytic pocket of tyrosyl-DNA phosphodiesterase 1
Authors: Zhao Xue Zhi , Barakat Idris A. , Lountos George T. , Wang Wenjie , Agama Keli , Mahmud Md Rasel Al , Suazo Kiall F. , Andresson Thorkell , Pommier Yves , Burke Terrence R. 
Published: September 2024

AbstractDeveloping effective inhibitors of the DNA repair enzyme tyrosyl-DNA phosphodiesterase 1 (TDP1) has been challenging because of the enzyme shallow catalytic pocket and non-specific substrate binding interactions. Recently, we discovered a quinolone-binding hot spot in TDP1’s active site proximal to the evolutionary conserved Y204 and F259 residues that position DNA. Sulfur (VI) fluoride exchange (SuFEx) is a biocompatible click chemistry reaction that enables acylation of protein residues, including tyrosine. Selective protein modifications can provide insights into the biological roles of proteins and inform ligand design. As we report herein, we used SuFEx chemistries to prepare covalent TDP1-bound binders showing site-specific covalent bonds with Y204. Our work presents the first application of SuFEx chemistries to TDP1 ligands. It validates the ability to covalently modify specific TDP1 residues by designed targeting and adds to the chemical biology resource toolbox for studying TDP1.
SOX10 mediates glioblastoma cell-state plasticity
Authors: Man Ka-Hou , Wu Yonghe , Gao Zhenjiang , Spreng Anna-Sophie , Keding Johanna , Mangei Jasmin , Boskovic Pavle , Mallm Jan-Philipp , Liu Hai-Kun , Imbusch Charles D , Lichter Peter , Radlwimmer Bernhard 
Published: September 2024

AbstractPhenotypic plasticity is a cause of glioblastoma therapy failure. We previously showed that suppressing the oligodendrocyte-lineage regulator SOX10 promotes glioblastoma progression. Here, we analyze SOX10-mediated phenotypic plasticity and exploit it for glioblastoma therapy design. We show that low SOX10 expression is linked to neural stem-cell (NSC)-like glioblastoma cell states and is a consequence of temozolomide treatment in animal and cell line models. Single-cell transcriptome profiling of Sox10-KD tumors indicates that Sox10 suppression is sufficient to induce tumor progression to an aggressive NSC/developmental-like phenotype, including a quiescent NSC-like cell population. The quiescent NSC state is induced by temozolomide and Sox10-KD and reduced by Notch pathway inhibition in cell line models. Combination treatment using Notch and HDAC/PI3K inhibitors extends the survival of mice carrying Sox10-KD tumors, validating our experimental therapy approach. In summary, SOX10 suppression mediates glioblastoma progression through NSC/developmental cell-state transition, including the induction of a targetable quiescent NSC state. This work provides a rationale for the design of tumor therapies based on single-cell phenotypic plasticity analysis.
7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively
Authors: Gaur Kishan Kumar , Asuru Tejeswara Rao , Srivastava Mitul , Singh Nitu , Purushotham Nikil , Poojary Boja , Das Bhabatosh , Bhattacharyya Sankar , Asthana Shailendra , Guchhait Prasenjit 
Published: September 2024

AbstractThere are a limited number of effective vaccines against dengue virus (DENV) and significant efforts are being made to develop potent anti-virals. Previously, we described that platelet-chemokine CXCL4 negatively regulates interferon (IFN)-α/β synthesis and promotes DENV2 replication. An antagonist to CXCR3 (CXCL4 receptor) reversed it and inhibited viral replication. In a concurrent search, we identified CXCR3-antagonist from our compound library, namely 7D, which inhibited all serotypes of DENV in vitro. With a half-life of ~2.85 h in plasma and no significant toxicity, 7D supplementation (8 mg/kg-body-weight) to DENV2-infected IFNα/β/γR−/−AG129 or wild-type C57BL6 mice increased synthesis of IFN-α/β and IFN-λ, and rescued disease symptoms like thrombocytopenia, leukopenia and vascular-leakage, with improved survival. 7D, having the property to inhibit Sirt-1 deacetylase, promoted acetylation and phosphorylation of STAT3, which in-turn increased plasmablast proliferation, germinal-center maturation and synthesis of neutralizing-antibodies against DENV2 in mice. A STAT3-inhibitor successfully inhibited these effects of 7D. Together, these observations identify compound 7D as a stimulator of IFN-α/β/λ synthesis via CXCL4:CXCR3:p38:IRF3 signaling, and a booster for neutralizing-antibody generation by promoting STAT3-acetylation in plasmablasts, capable of protecting dengue infection.
Adjustable ±24‐A current monitoring for battery applications with ±0.55% gain error from −40°C to 85°C
Authors: Wu Kaikai , Wang Hongyi , Chen Chen , Tao Tao 
Published: September 2024

AbstractThis study introduces a current‐sensing approach for battery monitoring and protection applications, using a low‐side shunt and an adjustable range. To address the challenge posed by the meagre resistance of the shunt, a preamplifier is used to amplify the small voltage signal across the shunt. The current sensing process incorporates chopper techniques, a current feedback instrumentation amplifier, and mismatch optimization methods to minimize sensing errors effectively. In addition to these methods, the conversion of current into digital form is facilitated by an analogue‐to‐digital converter. Trimming correction is used to mitigate the remaining errors. The current sensing circuit is realized using a 0.18 µm high voltage 100 V bipolar‐CMOS‐DMOS process. Remarkably, this circuit exhibits a gain error of ±0.55% across a range of ±24 A, spanning temperatures from −40°C to 85°C. Operating from a 5‐V LDO supply, it maintains an average current consumption of 12.9 µA while occupying an active area of 0.34 mm2.