bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epa Guidance on Emental Health Interventions in the Treatment of Posttraumatic Stress Disorder (Ptsd)
Authors: Gaebel W. , Großimlinghaus I. , Mucic D. , Maercker A. , Zielasek J. , Kerst A. 
Published: January 2017

AbstractThe aim of this EPA guidance was to develop recommendations on eMental health interventions in the treatment of posttraumatic stress disorder (PTSD). A systematic literature search was performed and 40 articles were retrieved and assessed with regard to study characteristics, applied technologies, therapeutic approaches, diagnostic ascertainment, efficacy, sustainability of clinical effects, practicability and acceptance, attrition rates, safety, clinician-supported vs. non-supported interventions and active vs. waiting-list controls. The reviewed studies showed a great heterogeneity concerning study type, study samples, interventions and outcome measures. Based on these findings, five graded recommendations dealing with symptom reduction, acceptability, type of administration, clinician support, self-efficacy and coping were developed.
Efficacy and safety of barbed suture in minimally invasive radical prostatectomy: A systematic review and meta‐analysis
Authors: Lin Yi‐Fei , Lai Si‐ke , Liu Qin‐Yu , Liao Bang‐Hua , Huang Jin , Du Liang , Wang Kun‐Jie , Li Hong 
Published: January 2017

AbstractAs one of the earliest surgeries applying knotless barbed suture, the minimally invasive radical prostatectomy (MIRP) was reported to have various effects on the patients and the surgeons. This study reviewed the available evidence about the efficacy and safety of barbed sutures in MIRP. We searched ClinicalTrials.gov, Cochrane Register of Clinical Studies, PubMed, and Embase to identify randomized controlled trials (RCTs) and cohort studies addressing the application of barbed sutures and conventional sutures in MIRP (until August 2016). Quality assessment was performed according to Cochrane recommendations. The data were analyzed using Review Manager (Version 5.3), and sensitivity analysis was performed by sequentially omitting each study. A total of 12 studies, including three RCTs (low to moderate risk of bias, 211 patients) and nine cohort studies (low to moderate risk of bias, 698 patients), fulfilled the study criteria. The pooling of trials did not show statistical difference. Pooling data of cohort studies showed that suture time [mean difference (MD) = −8.52, 95% confidence interval (CI) = −12.60 to −4.43, p < 0.0001] and length of hospital stay (MD = −0.96, 95% CI = −1.80 to −0.11, p = 0.03) were significantly shorter in the barbed group. Results of continence rate varied according to different studies. Subgroup analysis by type of MIRP suggested that patients who underwent barbed suture during robot‐assisted surgeries had a shorter hospital stay (MD = −1.13, 95% CI = −1.82 to −0.45, p = 0.001). During the laparoscopic surgery, patients in the barbed suture group had fewer postoperative complications [odds ratio = 0.29, 95% CI = 0.08–0.98, p = 0.05). However, more evidence is needed to validate this state‐of‐the‐art technology.
Asynchronous behavior of outlet glaciers feeding Godthåbsfjord (Nuup Kangerlua) and the triggering of Narsap Sermia's retreat in SW Greenland
Authors: MOTYKA ROMAN J. , CASSOTTO RYAN , TRUFFER MARTIN , KJELDSEN KRISTIAN K. , VAN AS DIRK , KORSGAARD NIELS J. , FAHNESTOCK MARK , HOWAT IAN , LANGEN PETER L. , MORTENSEN JOHN , LENNERT KUNUK , RYSGAARD SØREN 
Published: January 2017

ABSTRACTWe assess ice loss and velocity changes between 1985 and 2014 of three tidewater and five-land terminating glaciers in Godthåbsfjord (Nuup Kangerlua), Greenland. Glacier thinning accounted for 43.8 ± 0.2 km3 of ice loss, equivalent to 0.10 mm eustatic sea-level rise. An additional 3.5 ± 0.3 km3 was lost to the calving retreats of Kangiata Nunaata Sermia (KNS) and Narsap Sermia (NS), two tidewater glaciers that exhibited asynchronous behavior over the study period. KNS has retreated 22 km from its Little Ice Age (LIA) maximum (1761 AD), of which 0.8 km since 1985. KNS has stabilized in shallow water, but seasonally advects a 2 km long floating tongue. In contrast, NS began retreating from its LIA moraine in 2004–06 (0.6 km), re-stabilized, then retreated 3.3 km during 2010–14 into an over-deepened basin. Velocities at KNS ranged 5–6 km a−1, while at NS they increased from 1.5 to 5.5 km a−1 between 2004 and 2014. We present comprehensive analyses of glacier thinning, runoff, surface mass balance, ocean conditions, submarine melting, bed topography, ice mélange and conclude that the 2010–14 NS retreat was triggered by a combination of factors but primarily by an increase in submarine melting.
Dietary responses of Sahul (Pleistocene Australia–New Guinea) megafauna to climate and environmental change
Authors: DeSantis Larisa R. G. , Field Judith H. , Wroe Stephen , Dodson John R. 
Published: January 2017

AbstractThroughout the late Quaternary, the Sahul (Pleistocene Australia–New Guinea) vertebrate fauna was dominated by a diversity of large mammals, birds, and reptiles, commonly referred to as megafauna. Since ca. 450–400Ka, approximately 88 species disappeared in Sahul, including kangaroos exceeding 200kg in size, wombat-like animals the size of hippopotamuses, flightless birds, and giant monitor lizards that were likely venomous. Ongoing debates over the primary cause of these extinctions have typically favored climate change or human activities. Improving our understanding of the population biology of extinct megafauna as more refined paleoenvironmental data sets become available will assist in identifying their potential vulnerabilities. Here, we apply a multiproxy approach to analyze fossil teeth from deposits dated to the middle and late Pleistocene at Cuddie Springs in southeastern Australia, assessing relative aridity via oxygen isotopes as well as vegetation and megafaunal diets using both carbon isotopes and dental microwear texture analyses. We report that the Cuddie Springs middle Pleistocene fauna was largely dominated by browsers, including consumers of C4shrubs, but that by late Pleistocene times the C4dietary component was markedly reduced. Our results suggest dietary restriction in more arid conditions. These dietary shifts are consistent with other independently derived isotopic data from eggshells and wombat teeth that also suggest a reduction in C4vegetation after ~45 Ka in southeastern Australia, coincident with increasing aridification through the middle to late Pleistocene. Understanding the ecology of extinct species is important in clarifying the primary drivers of faunal extinction in Sahul. The results presented here highlight the potential impacts of aridification on marsupial megafauna. The trend to increasingly arid conditions through the middle to late Pleistocene (as identified in other paleoenvironmental records and now also observed, in part, in the Cuddie Springs sequence) may have stressed the most vulnerable animals, perhaps accelerating the decline of late Pleistocene megafauna in Australia.
D. A. Ọbasa (1879–1945): a Yoruba poet, culture activist and local intellectual in colonial Nigeria
Authors: Akinyẹmi Akintunde 
Published: January 2017

AbstractThis article examines the works of one of the earliest Yoruba poets, Denrele Adetimikan Ọbasa (1879–1945), a member of the local intelligentsia in colonial Nigeria. In my assessment of the poet as a culture activist and local intellectual, I draw on biographical information, extensive archival research and relevant textual illustration. The central argument of the article is that Ọbasa exploits Yoruba communal oral resources for ideas, themes and other linguistic influences in his poetry. Therefore, the essay explores the creative ability of Ọbasa to preserve different forms of oral literary material in his poetic composition and how he uses the folkloric materials as instruments for raising the social consciousness of his readers. At this level, the article argues, Ọbasa transforms oral traditions into metaphorical and symbolic language that best articulates his political or philosophical positions. Thus, orality is not static, but dynamic, flexible and adaptable to change. The main article offers translations of excerpts from Ọbasa's poetry, while the online supplementary material offers more complete samples of Ọbasa's poems.
‘Kakube has come to stay’: the making of a cultural festival in Northern Ghana, 1989–2015
Authors: Lentz Carola , Wiggins Trevor 
Published: January 2017

AbstractIn Ghana, cultural festivals, usually initiated and organized by the chiefs, provide public arenas where local and regional political elites voice demands vis-à-vis central government, and where national politicians canvass for support. Festivals offer commercial opportunities, forums to promote ‘development’, and occasions for entertainment. Yet advocating for ‘our own culture’ stands out as their very raison d’être, offering a frame for cultural entrepreneurs to organize performances that express and reconfigure local styles of music and dance to fit national formats. In this article, we examine such processes of cultural creation for the Kakube Festival in Nandom, a paramount chiefdom in north-western Ghana. We analyse the cultural building blocks and their evolution during the festival's history as well as the context of changing national politics of cultural heritage in which the festival developed. We discuss the invention of a cultural festival to create local alliances and stake claims at the regional and national political level, and how the desire to assert a presence in the national political and cultural arena has transformed the ways in which local culture is defined and presented. We examine the tensions at the heart of such an event, where traditions of chiefly patronage and allegiance meet the requirements of modern political and bureaucratic systems of funding, and the criteria of excellence in cultural performance. Music and dance are essential components and we analyse the evolution and adaptation of these elements alongside the critical path management of the event that has led to its local and national profile.
Contemplating the GANE model using an extreme case paradigm
Authors: Geva Ronny 
Published: January 2017

AbstractEarly experiences play a crucial role in programming brain function, affecting selective attention, learning, and memory. Infancy literature suggests an extension of the GANE (glutamate amplifies noradrenergic effects) model to conditions with minimal priority-map inputs, yet suggests qualifications by noting that its efficacy is increased when tonic levels of arousal are maintained in an optimal range, in manners that are age and exposure dependent.
Tooth wear: a cross-sectional investigation of the prevalence and risk factors in Beijing, China
Authors: Sun Kan , Wang Wenhui , Wang Xiaozhe , Shi Xiangru , Si Yan , Zheng Shuguo 
Published: January 2017

Abstract
Objectives:
The aim of this study was to evaluate the epidemiology of tooth wear in Beijing and to establish appropriate preventive measures.

Materials and Methods:
This cross-sectional analysis involved a questionnaire survey conducted for 1,812 individuals aged 12–74 years in Beijing. Subjects were local residents living in the region for >6 months before the survey. Subjects were evaluated using clinical examinations with the basic erosive wear examination index and a self-administered questionnaire. Statistical analyses were performed using SPSS software.

Results:
The prevalence of maxillary tooth wear was 84.9% for the molars, 68.9% for the premolars, 74.1% for the canines and 97% for the incisors. In the mandible, the corresponding prevalence rates were 85.2%, 59.3%, 78.6% and 97.4%, respectively. The occlusal, incisal and cervical surfaces showed more frequent wear compared with the other surfaces. Age, acidic beverages, xerostomia and brushing habits were identified as risk factors for tooth wear (P<0.05).

Conclusions:
Tooth wear is common in Beijing. Specific preventive measures should be recommended for individuals reporting excessive consumption of fruits and/or acidic beverages, and those with xerostomia. In particular, incisor wear should be carefully monitored in individuals of all age groups.
Glia-derived ATP inversely regulates excitability of pyramidal and CCK-positive neurons
Authors: Tan Zhibing , Liu Yu , Xi Wang , Lou Hui-fang , Zhu Liya , Guo Zhifei , Mei Lin , Duan Shumin 
Published: January 2017

AbstractAstrocyte responds to neuronal activity with calcium waves and modulates synaptic transmission through the release of gliotransmitters. However, little is known about the direct effect of gliotransmitters on the excitability of neuronal networks beyond synapses. Here we show that selective stimulation of astrocytes expressing channelrhodopsin-2 in the CA1 area specifically increases the firing frequency of CCK-positive but not parvalbumin-positive interneurons and decreases the firing rate of pyramidal neurons, phenomena mimicked by exogenously applied ATP. Further evidences indicate that ATP-induced increase and decrease of excitability are caused, respectively, by P2Y1 receptor-mediated inhibition of a two-pore domain potassium channel and A1 receptor-mediated opening of a G-protein-coupled inwardly rectifying potassium channel. Moreover, the activation of ChR2-expressing astrocytes reduces the power of kainate-induced hippocampal ex vivo gamma oscillation. Thus, through distinct receptor subtypes coupled with different K+ channels, astrocyte-derived ATP differentially modulates the excitability of different types of neurons and efficiently controls the activity of neuronal network.
A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes
Authors: Shu Lingling , Hoo Ruby L. C. , Wu Xiaoping , Pan Yong , Lee Ida P. C. , Cheong Lai Yee , Bornstein Stefan R , Rong Xianglu , Guo Jiao , Xu Aimin 
Published: January 2017

AbstractThe adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications. Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes. We find that A-FABP levels are increased in both white (WAT) and brown (BAT) adipose tissues and the bloodstream in response to thermogenic stimuli. A-FABP knockout mice have reduced thermogenesis and whole-body energy expenditure after cold stress or after feeding a high-fat diet, which can be reversed by infusion of recombinant A-FABP. Mechanistically, A-FABP induces the expression of type-II iodothyronine deiodinase in BAT via inhibition of the nuclear receptor liver X receptor α, thereby leading to the conversion of thyroid hormone from its inactive form T4 to active T3. The thermogenic responses to T4 are abrogated in A-FABP KO mice, but enhanced by A-FABP. Thus, A-FABP acts as a physiological stimulator of BAT-mediated adaptive thermogenesis.
Probing dark exciton diffusion using photovoltage
Authors: Mullenbach Tyler K. , Curtin Ian J. , Zhang Tao , Holmes Russell J. 
Published: January 2017

AbstractThe migration of weakly and non-luminescent (dark) excitons remains an understudied subset of exciton dynamics in molecular thin films. Inaccessible via photoluminescence, these states are often probed using photocurrent methods that require efficient charge collection. Here we probe exciton harvesting in both luminescent and dark materials using a photovoltage-based technique. Transient photovoltage permits a real-time measurement of the number of charges in an organic photovoltaic cell, while avoiding non-geminate recombination losses. The extracted exciton diffusion lengths are found to be similar to those determined using photocurrent. For the luminescent material boron subphthalocyanine chloride, the photovoltage determined diffusion length is less than that extracted from photoluminescence. This indicates that while photovoltage circumvents non-geminate losses, geminate recombination at the donor–acceptor interface remains the primary recombination pathway. Photovoltage thus offers a general approach for extracting a device-relevant diffusion length, while also providing insight in to the dominant carrier recombination pathways.
Hexagonal tungsten oxide nanoflowers as enzymatic mimetics and electrocatalysts
Authors: Park Chan Yeong , Seo Ji Min , Jo Hongil , Park Juhyun , Ok Kang Min , Park Tae Jung 
Published: January 2017

AbstractTungsten oxide (WOx) has been widely studied for versatile applications based on its photocatalytic, intrinsic catalytic, and electrocatalytic properties. Among the several nanostructures, we focused on the flower-like structures to increase the catalytic efficiency on the interface with both increased substrate interaction capacities due to their large surface area and efficient electron transportation. Therefore, improved WOx nanoflowers (WONFs) with large surface areas were developed through a simple hydrothermal method using sodium tungstate and hydrogen chloride solution at low temperature, without any additional surfactant, capping agent, or reducing agent. Structural determination and electrochemical analyses revealed that the WONFs have hexagonal Na0.17WO3.085·0.17H2O structure and exhibit peroxidase-like activity, turning from colorless to blue by catalyzing the oxidation of a peroxidase substrate, such as 3,3′,5,5′-tetramethylbenzidine, in the presence of H2O2. Additionally, a WONF-modified glassy carbon electrode was adopted to monitor the electrocatalytic reduction of H2O2. To verify the catalytic efficiency enhancement by the unique shape and structure of the WONFs, they were compared with calcinated WONFs, cesium WOx nanoparticles, and other peroxidase-like nanomaterials. The results indicated that the WONFs showed a low Michaelis-Menten constant (km), high maximal reaction velocity (vmax), and large surface area.
Targeting osteoblastic casein kinase-2 interacting protein-1 to enhance Smad-dependent BMP signaling and reverse bone formation reduction in glucocorticoid-induced osteoporosis
Authors: Liu Jin , Lu Changwei , Wu Xiaohao , Zhang Zongkang , Li Jie , Guo Baosheng , Li Defang , Liang Chao , Dang Lei , Pan Xiaohua , Peng Songlin , Lu Aiping , Zhang Baoting , Zhang Ge 
Published: January 2017

AbstractThe underlying mechanism of the reduced bone formation during the development of glucocorticoid-induced osteoporosis (GIO) remains unclear. Here, we found that the highly expressed CKIP-1 together with lowly expressed total and phosphorylated Smad1/5 in bone samples was accompanied by either the reduced serum bone formation markers in GIO patients or the decreased bone formation in GIO mice. In vitro studies showed that the highly expressed CKIP-1 could promote Smad1 ubiquitination to suppress the Smad-dependent BMP signaling and inhibit osteogenic differentiation and mineral deposition in MC3T3-E1 cells during glucocorticoid treatment. Further, the reduced bone formation in GIO mice could not only be prevented by osteoblasts-specific Ckip-1 ablation, but also be attenuated after osteoblasts-specific Smad1 overexpression. Moreover, osteoblasts-targeting CKIP-1 siRNA treatment also attenuated the bone formation reduction in GIO mice. These study suggest that the highly expressed CKIP-1 in osteoblasts could suppress the Smad-dependent BMP signaling and contribute to the bone formation reduction in GIO. Targeting osteoblastic CKIP-1 would be a novel bone anabolic strategy for GIO patients.
Computational design of an epitope-specific Keap1 binding antibody using hotspot residues grafting and CDR loop swapping
Authors: Liu Xiaofeng , Taylor Richard D. , Griffin Laura , Coker Shu-Fen , Adams Ralph , Ceska Tom , Shi Jiye , Lawson Alastair D. G. , Baker Terry 
Published: January 2017

AbstractTherapeutic and diagnostic applications of monoclonal antibodies often require careful selection of binders that recognize specific epitopes on the target molecule to exert a desired modulation of biological function. Here we present a proof-of-concept application for the rational design of an epitope-specific antibody binding with the target protein Keap1, by grafting pre-defined structural interaction patterns from the native binding partner protein, Nrf2, onto geometrically matched positions of a set of antibody scaffolds. The designed antibodies bind to Keap1 and block the Keap1-Nrf2 interaction in an epitope-specific way. One resulting antibody is further optimised to achieve low-nanomolar binding affinity by in silico redesign of the CDRH3 sequences. An X-ray co-crystal structure of one resulting design reveals that the actual binding orientation and interface with Keap1 is very close to the design model, despite an unexpected CDRH3 tilt and VH/VL interface deviation, which indicates that the modelling precision may be improved by taking into account simultaneous CDR loops conformation and VH/VL orientation optimisation upon antibody sequence change. Our study confirms that, given a pre-existing crystal structure of the target protein-protein interaction, hotspots grafting with CDR loop swapping is an attractive route to the rational design of an antibody targeting a pre-selected epitope.
RhBMP-2 loaded 3D-printed mesoporous silica/calcium phosphate cement porous scaffolds with enhanced vascularization and osteogenesis properties
Authors: Li Cuidi , Jiang Chuan , Deng Yuan , Li Tao , Li Ning , Peng Mingzheng , Wang Jinwu 
Published: January 2017

AbstractA major limitation in the development of effective scaffolds for bone regeneration has been the limited vascularization of the regenerating tissue. Here, we propose the development of a novel calcium phosphate cement (CPC)-based scaffold combining the properties of mesoporous silica (MS) with recombinant human bone morphogenic protein-2 (rhBMP-2) to facilitate vascularization and osteogenesis. Specifically, the development of a custom MS/CPC paste allowed the three-dimensional (3D) printing of scaffolds with a defined macroporous structure and optimized silicon (Si) ions release profile to promote the ingrowth of vascular tissue at an early stage after implantation in support of tissue viability and osteogenesis. In addition, the scaffold microstructure allowed the prolonged release of rhBMP-2, which in turn significantly stimulated the osteogenesis of human bone marrow stromal cells in vitro and of bone regeneration in vivo as shown in a rabbit femur defect repair model. Thus, the combination MS/CPC/rhBMP-2 scaffolds might provide a solution to issues of tissue necrosis during the regeneration process and therefore might be able to be readily developed into a useful tool for bone repair in the clinic.
Effect of the KF post-deposition treatment on grain boundary properties in Cu(In, Ga)Se2 thin films
Authors: Nicoara N. , Lepetit Th. , Arzel L. , Harel S. , Barreau N. , Sadewasser S. 
Published: January 2017

AbstractSignificant power conversion efficiency improvements have recently been achieved for thin-film solar cells based on a variety of polycrystalline absorbers, including perovskites, CdTe, and Cu(In,Ga)Se2 (CIGS). The passivation of grain boundaries (GBs) through (post-deposition) treatments is a crucial step for this success. For the case of CIGS, the introduction of a potassium fluoride post-deposition treatment (KF-PDT) has boosted their power conversion efficiency to the best performance of all polycrystalline solar cells. Direct and indirect effects of potassium at the interface and interface-near region in the CIGS layer are thought to be responsible for this improvement. Here, we show that also the electronic properties of the GBs are beneficially modified by the KF-PDT. We used Kelvin probe force microscopy to study the effect of the KF-PDT on the CIGS surface by spatially resolved imaging of the surface potential. We find a clear difference for the GB electronic properties: the KF-PDT increases the band bending at GBs by about 70% and results in a narrower distribution of work function values at the GBs. This effect of the KF-PDT on the GB electronic properties is expected to contribute to the improved efficiency values observed for CIGS thin-film solar cells with KF-PDT.