bluuebunny/crossref_metadata_2025_split huggingface dataset:
LC-MS/MS-based metabolomics and proteomics reveal the intervention of Kangnian decoction on the postoperative intestinal adhesion of rats
Authors: Jin Liang , Zhao Yuan , Qian Xiaojing , Pan Lingyun , Chen Long , Feng Jingwen , Liu Xinhua , Lu Xiaotong 
Published: September 2024

BackgroundPostoperative Intestinal Adhesions (PIAs) remain a significant complication of abdominal surgery that can cause pain, infertility, and a potentially lethal bowel obstruction. Kangnian (KN) decoction, a Traditional Chinese Medicine prescription, has been shown to be effective in treating PIAs. Nevertheless, its underlying mechanisms remain unclear.ObjectiveThis study aims to explore the therapeutic effects of KN decoction in a PIA rat model, as well as its potential mechanisms via metabolomics and proteomics analyses.Materials and methods60 rats were randomly assigned to six groups: Normal Control (NC), PIA model, Dexamethasone, KN-Low, KN-Medium, and KN-High. The PIA model was created by abdominal surgery under anesthesia. Pathological damage was evaluated through H&amp;E staining and adhesion grading of affected tissues. The levels of serum cytokines (IL-1β, IL-6, TNF-α, and TGF-1), Connective Tissue Growth Factor (CTGF), and Motilin (MTL) in adherent intestinal tissues were detected using ELISA kits. Untargeted metabolomics was used to investigate potential metabolic pathways of the KN decoction intervention in intestinal adhesions and to screen for differential biomarkers. The label-free quantitative proteomics technique was employed to detect Differentially Expressed Proteins and for biological function and pathway enrichment analyses.ResultsIn PIA rats, KN decoction significantly improved the pathological injury associated with intestinal adhesions and effectively regulated the blood inflammation indicators. Furthermore, KN presented a favorable anti-fibrotic and protective effect against abdominal adhesions, effectively modifying gastrointestinal motility disorders in PIA rats. We identified 58 variables as potential biomarkers and discovered seven main pathological pathways that may be associated with PIAs. Proteomics analysis revealed 75 DEPs that were primarily involved in Valine, leucine, and isoleucine degradation, the MAPK signaling pathway, and retrograde endocannabinoid signaling.ConclusionThis study proved that KN reduces intestinal mucosal injury, downregulates inflammatory factors, and alleviates intestinal adhesions, thus protecting the intestinal barrier function in PIA rats. The combination of proteomics and metabolomics provided a feasible approach for unraveling the therapeutic mechanism of KN decoction in PIAs.
Integrated analyses reveal IDO1 as a prognostic biomarker coexpressed with PD-1 on tumor-associated macrophages in esophageal squamous cell carcinoma
Authors: Peng Yaojun , Wang Lingxiong , Yang Juan , Wu Qiyan , Sun Xiaoxuan , Zhang Jinying , Yu Yanju , Zhang Liping , Gao Jie , Zhou Qing , Zhu Haiyan , Yin Fan 
Published: September 2024

BackgroundInhibition of indolamine-2,3-dioxygenase 1 (IDO1) has been proposed as a promising strategy for cancer immunotherapy; however, it has failed in clinical trials. Macrophages in the tumor microenvironment (TME) contribute to immune escape and serve as potential therapeutic targets. This study investigated the expression pattern of IDO1 in TME and its impact on prognosis and therapeutic response of patients with esophageal squamous cell carcinoma (ESCC).MethodsRNA sequencing data from 95 patients with ESCC from The Cancer Genome Atlas (TCGA) database were used to explore the prognostic value of IDO1. Bioinformatics tools were used to estimate scores for stromal and immune cells in tumour tissues, abundance of eight immune cell types in TME, and sensitivity of chemotherapeutic drugs and immune checkpoint (IC) blockage. The results were validated using digitalized immunohistochemistry and multiplexed immunofluorescence in ESCC tissue samples obtained from our clinical center.ResultsTCGA and validation data suggested that high expression of IDO1 was associated with poor patient survival, and IDO1 was an independent prognostic factor. IDO1 expression positively correlated with macrophages in TME and PDCD1 within diverse IC genes. Single-cell RNA sequencing data analysis and multiplexed immunofluorescence verified the coexpression of IDO1 and PD-1 in tumor-associated macrophages (TAMs). Patients with high IDO1 expression showed increased sensitivity to various chemotherapeutic drugs, while were more likely to resist IC blockage.ConclusionThis study identifies IDO1 as an independent prognostic indicator of OS in patients with ESCC, reveals a compelling connection of IDO1, PD-1, and TAMs, and explores the sensitivity of patients with high IDO1 expression to chemotherapeutic drugs and their resistance to IC blockade. These findings open new avenues for potential targets in ESCC immunotherapy.
Examination of the validity of the Chinese version of the Language Mindsets Inventory among Chinese university students
Authors: Cai Pengpeng , Li Xuhong , Mai Zheyuan , Feng Juxiong , Guan Xin 
Published: September 2024

IntroductionWith the growing interest in the psychological basis of language learning, this study aims to validate the Chinese version of the Language Mindset Inventory (LMI) among Chinese university students.MethodsA sample of 476 students from various universities in mainland China was used. The translation process followed the forward-backward method. Confirmatory factor analyses (CFAs) were conducted to evaluate the factor structure. The internal consistency of the LMI was assessed using Cronbach's alpha, and convergent validity was examined through correlations with established mindset measures.ResultsCompared with the one-factor model, the two-factor model which distinguishes between fixed and growth mindsets, showed an acceptable and better fit index. The overall Cronbach's alpha for the full scale was 0.954, with 0.929 for the fixed mindset dimension and 0.903 for the growth mindset dimension. AVE values for the fixed and growth dimensions were 0.597 and 0.510, respectively. Correlations showed that the growth mindset dimension was significantly positively associated with the 8-Item Growth Mindset Scale (r = 0.186, p &lt; 0.01) and the Mindset Scale for Learning English (r = 0.149, p &lt; 0.01), while the fixed mindset dimension was negatively associated with both scales (r = −0.228 and r = −0.169, p &lt; 0.01).DiscussionThis study confirms the reliability and validity of the Chinese version of the LMI, making it a relevant tool for assessing language learning mindsets among Chinese university students. The findings support the integration of LMI into educational strategies to promote resilience and adaptability, enhancing language education outcomes.
Outdoor recess is associated with more positive attitudes toward physical activity among pre-adolescent students and their parents
Authors: Lemberg Getter Marie , Kull Merike , Mäestu Jarek , Riso Eva-Maria , Mägi Katrin , Mäestu Evelin 
Published: September 2024

IntroductionSchool day structure has the potential to increase students’ physical activity (PA) levels and form positive attitudes about PA. Including various PA opportunities and free play possibilities in the school schedule, especially outdoor recess, can improve students’ moderate-to-vigorous PA (MVPA) levels during school time. Therefore, the main aim of the study was to investigate students’ and their parents’ attitudes about outdoor recess and PA opportunities in schools with different recess opportunities.MethodsStudents from grades three to six (9–13-year-olds) and their parents responded to a questionnaire about the effect of outdoor recess and opportunities for PA during the school day. Schools were divided into three groups based on the recess opportunities during the school day: (1) “outdoor recess”, (2) “outdoor recess on some days”, (3) “indoor recess”.ResultsStudents and parents of the “outdoor recess” group had significantly more positive attitudes about outdoor recess and PA opportunities in school. Students of the “outdoor recess” group stated being significantly more active during their leisure-time compared to other groups. Parents of the “outdoor recess” group stated that the school has asked their opinion regarding PA opportunities during the school day significantly more compared to the other two groups.DiscussionThese findings emphasize the positive effect outdoor recess can have on students’ PA beliefs and habits. Parents of the “outdoor recess” group also had more positive attitudes toward PA which is important as parents most likely convey their attitudes and beliefs to their children. In addition, involving and informing parents is critical when changing the school schedule and introducing new school culture, to make the changes last.
Factors influencing the relationship between coaches and athletes with disabilities: a systematic review
Authors: Liu Junyan , Yu Hongjun , Bleakney Adam , Jan Yih-Kuen 
Published: September 2024

IntroductionThe relationship between coaches and athletes with disabilities is critical for enhancing athletes' performance and psychosocial well-being. This study aims to provide evidence-based recommendations for coaches, sports organizations, and policymakers dedicated to supporting athletes with disabilities.MethodsA comprehensive analysis of existing literature was conducted. Five databases were searched, including PubMed, Web of Science, SPORTDiscus, Google Scholar, and China National Knowledge Infrastructure. A total of 22 studies were included for thematic analysis.ResultsThis systematic review identifies key factors influencing the coach-athlete relationship in disabled sports. These factors are categorized into three main domains: professional, interpersonal, and intrapersonal. In the professional domain, effective coaching requires sport-specific skills and adaptive techniques tailored to the unique needs of athletes with disabilities. Coaches must understand the technical and tactical aspects of each parasport and adapt training plans to optimize performance and foster independence. The interpersonal domain emphasizes communication strategies and team-building practices. Effective communication involves understanding athletes' needs and adapting approaches to maximize strengths. Building rapport, managing conflict, and fostering a supportive team environment are crucial for maintaining a positive coach-athlete relationship. The intrapersonal domain highlights the importance of self-reflection and continuous learning. Coaches who engage in self-reflection and professional development better understand their behaviors and biases, enabling them to tailor coaching strategies to the specific needs of athletes with disabilities. Continuous learning is essential for remaining responsive to the evolving needs of these athletes.DiscussionThis review underscores the importance of a holistic approach that integrates professional expertise, interpersonal skills, and intrapersonal awareness. By addressing these factors, it provides a foundation for developing more effective coaching strategies and supports for athletes with disabilities, ultimately enhancing their performance and well-being. Future research should explore cultural differences, the specific coaching needs of athletes with intellectual disabilities, and the impact of policies and structural barriers on the coach-athlete relationship in disabled sports.
Evaluation of the sustainable development level of grain family farms in main grain-producing areas based on agricultural multi-function: a case study of Hunan Province in China
Authors: Duan Wei , Pan Yuehong 
Published: September 2024

IntroductionGrain family farms play an important role in promoting agricultural modernization and rural revitalization in China. Taking Hunan Province as an example, based on survey data from 400 grain family farms and agricultural multi-function theory, 24 specific indicators were selected from three dimensions-economic benefits, social benefits, and ecological benefits-to construct an evaluation system for the sustainable development level of grain family farms.MethodsThe entropy weight TOPSIS method was used to measure the sustainable development level of grain family farms in Hunan Province, and the obstacle factor diagnosis model was used to explore the main obstacle factors affecting the sustainable development of grain family farms.Results(1) The sustainable development level of grain family farms in Hunan Province was classified as good overall with respect to the classification criteria of existing relevant studies, but there were comparative differences in each dimension among the four regions (central Hunan, northern Hunan, southern Hunan, and western Hunan) of Hunan Province. (2) According to the diagnosis and analysis results of the obstacle degree, the top six obstacle factors affecting the sustainable development level of grain family farms in Hunan Province were the effective use of water resources, soil protection, and improvement efforts, the number of agricultural ecological culture inheritance activities, carbon emission management, the number of jobs provided for farmers, and adaptability to external environmental changes.DiscussionRelevant policies and systems should be formulated based on local conditions to enhance the integrity and synergy of the development of grain family farms in Hunan Province and to enhance the sustainable development ability of grain family farms in Hunan Province.
Chronic subdural hematoma in the posterior fossa
Authors: Idir Abdelilah , Elmajdoub Youssef , Okacha Naama , Boulahroud Omar 
Published: September 2024

Chronic subdural hematoma (CSH) in the posterior fossa is extremely rare in the adult population. CT scanning is generally accurate and sufficiently sensitive in the diagnosis of supratentorial subdural hematomas, while MRI has clearly shown its superiority in the detection of subdural collections at unusual locations and particularly in the detailed analysis of the posterior cranial fossa. The surgical strategy is still controversial. We report a case of CSH in the posterior fossa successfully treated with a suboccipital craniectomy. A 70-year-old man; has developed headaches, nausea, cerebellar syndrome and ataxia of walking. Radiological examinations revealed the appearance of a right CSH in the posterior fossa associated with hydrocephalus. Upon rapid deterioration of the patient’s consciousness, urgent treatment was required. A small right suboccipital craniectomy was to access the hematoma. Postoperative computed tomography showed that the CSH and hydrocephalus had been successfully treated.
Design parameters of the household water consumption rates and pressures in a water distribution network
Authors: Стрелков А.К. , Теплых С.Ю. , Горшкалев П.А. , Котовская Е.Е. 
Published: September 2024

Водопроводная сеть, являясь частью системы водоснабжения, осуществляет распределение воды по населенному пункту и подачу воды потребителям. Для нормального снабжения потребителей водой в сети должны быть обеспечены минимальные свободные напоры, гарантирующие бесперебойную подачу воды. С введением новой редакции СП 31.13331 от 2021 г. «Водоснабжение. Наружные сети и сооружения» принцип определения расчетных значений минимальных свободных напоров в сети водопровода поселения или города при максимальном хозяйственно-питьевом водопотреблении на вводе в здание над поверхностью земли изменился. В соответствии с этими данными рассчитаны минимальные свободные напоры в водопроводной сети и выполнено сравнение их величин со свободными напорами, на которые проектировались водопроводные сети населенных пунктов до 2021 г.
Being a part of the water supply system, a water distribution network provides for the water distribution around a community and supply to the consumers. To ensure standard water supply to the consumers the minimum free pressures that guarantee uninterrupted water supply shall be provided in the water distribution network. With the introduction of the revised version of CP 31.13331 of 2021 «Water supply. External networks and structures», the principle of determining the design values of minimum free pressures at the entrance facility above the ground surface in the water distribution network of a community or city at the maximum household water consumption has changed. According to these data, the minimum free pressures in the water distribution network were calculated and their values were compared with the free pressures in the public water distribution networks that had been designed before 2021.
Mathematical simulation of wastewater treatment processes in aeration tanks
Authors: Степанов С.В. , Харькина О.В. , Авдеенков П.П. , Лазунин М.В. , Пономаренко О.С. 
Published: September 2024

Разработан новый вариант математической модели процессов очистки сточных вод в аэротенках с биологическим удалением азота и биолого-химическим удалением фосфора на основе взаимного дополнения методик ВОДГЕО/СамГТУ и ASM2d. Математически решена «обратная задача» технологического расчета аэротенков – определение концентраций загрязнений в очищенной воде при имеющихся данных по качественному и количественному составу исходной воды для заданных значений технологических и конструктивных параметров сооружений. Разработан алгоритм выдачи количественных технологических рекомендаций. На основании проведенных исследований разработано программное обеспечение «Потенциал», предназначенное для сбора исходных данных, выполнения технологических расчетов и выдачи рекомендаций персоналу очистных сооружений. Внедрение программного обеспечения позволит снизить эксплуатационные затраты за счет оптимизации технологического режима работы сооружений биологической очистки сточных вод в минимальные сроки.
A new version of the mathematical model of wastewater treatment processes in aeration tanks with biological nitrogen removal and biological-chemical phosphorus removal has been developed based on the mutual complementation of the VODGEO/SamGTU and ASM2d methods. The «inverse problem» of technological calculation of aeration tanks has been solved mathematically, i. e. by determining the pollution concentrations in effluent with available data on the qualitative and quantitative composition of the raw wastewater for the specified values of process and design parameters of the facilities. An algorithm for providing quantitative process recommendations has been developed. Following the conducted research, the Potential software was developed designed for the primary acquisition, technological calculations and providing recommendations to the personnel of the treatment facilities. The implementation of the software will reduce the operating costs by optimizing the process flow pattern of the biological wastewater treatment facilities in the shortest possible time.
Wastewater treatment of PVC floor tile production
Authors: Стрелков А.К. , Тараканов Д.И. , Негода Л.Л. , Пискунов К.С. 
Published: September 2024

Представлены результаты исследований по очистке воды, образующейся при производстве ПВХ-плитки, содержащей продукты термического разложения исходных материалов. Сточная вода имеет повышенные значения показателя ХПК, солесодержания, концентраций хлоридов и сульфатов. В работе были проведены экспериментальные исследования по очистке данных сточных вод путем обработки их окислителями и коагулянтами. Исследования были выполнены с использованием окислителей: пероксид водорода, гипохлорит натрия, трихлоризоциануровая кислота (Лонгафор), а также коагулянтов: Эквиталл, Аурат ЭПОХА, Уникоф™-М. В работе показано, что наилучшие результаты очистки были получены при использовании реагентов Лонгафор и Эквиталл. Эффективность очистки по показателю ХПК составила 70%.
The results of studies on the purification of wastewater generated during the production of PVC tiles containing products of thermal decomposition of the raw materials are presented. The wastewater contains increased values of COD, salt content, chloride and sulfate concentrations. During the research work experimental studies were conducted on the purification of this wastewater by adding oxidizers and coagulants. The studies were conducted using the following oxidizers: hydrogen peroxide, sodium hypochlorite, trichloroisocyanuric acid (Longafor), as well as coagulants: Equitall, Aurat EPOKHA, Unikof™-M. The studies showed that the best purification results were obtained using Longafor and Equitall chemicals. The purification efficiency in terms of COD removal was 70%.
Issues of classifying surface runoff, treatment technologies and methods
Authors: Павлухин А.А. , Шувалов М.В. , Палагин Е.Д. 
Published: September 2024

Приводится анализ качественного состава поверхностных сточных вод и требований к их очистке в зависимости от особенностей приемника очищенных сточных вод. При выборе технологических решений и основного состава очистных сооружений для достижения необходимой эффективности очистки предложено использовать комплексный подход. Для его реализации разработана классификация поверхностных сточных вод и основных технологических процессов очистки с дифференциацией в зависимости от нормативных требований к очищенным сточным водам. Предлагаемая классификация позволяет унифицировать процедуру выбора основных технологических решений.
An analysis of the qualitative composition of surface runoff and treatment requirements depending on the characteristics of the effluent receiving water are presented. A comprehensive approach is proposed while choosing process solutions and the basic composition of the treatment facilities to achieve the required treatment efficiency. For the implementation a classification of surface runoff and the main treatment processes with differentiation depending on the regulatory requirements to the effluent has been developed. The proposed classification provides for unifying the procedure for choosing the main process solutions.
Edukasi Literasi Digital Marketing Bagi Pelaku UMKM di Pasar Sentral Medan
Authors: Christiana Irma , Fransisca Chinta Felsya , Manurung Alyssia Putri , Saputri Septia Mayang , Zahra Diah Ayu 
Published: September 2024

Tujuan dari kegiatan ini adalah untuk meningkatkan pengetahuan dan keterampilan tentang digital marketing dan e-commerce untuk usaha mikro, kecil, dan menengah sebagai upaya meningkatkan penjualan dan keuntungan mereka. Metode yang digunakan dalam kegiatan ini diantaranya: penjelasan, pengalaman berbagi dan diskusi, serta praktik langsung membuat akun Shopee dan bagaimana membuatnya menarik bagi pembeli. Objeknya adalah toko “Pulungan Fashion” yang terletak di kios lantai 2 No.508-509 Pasar Sentral Medan. Hasilnya menunjukkan pelaku UMKM tidak pernah menggunakan digital marketing karena kurangnya keterampilan teknologi. Namun, mereka menunjukkan minat besar untuk menggunakan digital marketing dan e-commerce secara berkelanjutan.