bluuebunny/crossref_metadata_2025_split huggingface dataset:
Arctic governance, indigenous knowledge, science and technology in times of climate change
Authors: Arruda Gisele M. , Krutkowski Sebastian 
Published: June 2017

PurposeThis paper aims to place a discussion of traditional knowledge and the indigenous voice within the framework of Arctic governance.Design/methodology/approachThe study involves literature review spanning different disciplines and highlighting important case studies.FindingsThe advance of low-cost, portable technology has brought about tremendous opportunities for indigenous people. Knowledge and observation are no longer monopolised by scholars, filmmakers or politicians based in the West. Film has proved to be a powerful tool for cultural preservation while the internet (video sharing sites and social media platforms in particular) have empowered local communities and facilitated their involvement in political activism and local governance. New ways to represent themselves have been a crucial step forward, yet the new goal is to work towards greater recognition of the “indigenous voice” and ensure traditional knowledge is not treated as anecdotal and irrelevant in managing Arctic affairs..Research limitations/implicationsThe conclusions reached in the discussion need to be further explored by extending the research into Inuit communities to survey how technology can facilitate and impact collaborative forms of governance in the Arctic.Practical implicationsThis research provides an increased understanding of how technology transforms power relations. Policymakers can see that the indigenous community in the Arctic is not lodged in the past. Their increased use of new technology can serve as an effective oversight of political decisions and economic initiatives, particularly those relating to oil and gas exploration in the region.Social implicationsIndigenous views and knowledge are literally crossing borders through media. Initially perceived as a cultural threat, film, video and internet are now regarded as powerful technology tools for cultural preservation and empowerment of local communities. In other words, the modern communication patterns are a crucial mean of indigenous population take part of the current global debate, express their concerns, reinforce their values and traditions and have an active voice in the globalised world.Originality/valueThis paper illustrates how technology helps indigenous communities to address different economic, environmental, cultural, educational, research and other issues in the Arctic. Robust evidence is presented to support the call for traditional knowledge to become an integral part of decision-making processes across all institutions of governance in the Arctic.
The short-term response of the Hispanic noncitizen population to anti-illegal immigration legislation
Authors: Sánchez Gonzalo E. 
Published: June 2017

Purpose
This paper aims to examine the short-term effect of the Arizona Immigration Law of 2010 (SB 1070) on the noncitizen Hispanic state population.

Design/methodology/approach
To get a consistent estimate of this effect, a synthetic control method has been used to calculate a suitable counterfactual.

Findings
Results indicate that this bill produced a statistically significant short-term reduction in the proportion of noncitizen Hispanics in Arizona between 10 and 15 per cent. However, the evidence suggests that this effect vanishes after a few months.

Originality/value
These findings are consistent with previous evidence of the high mobility of the undocumented population in the US, and contribute to the understanding of the effects of federal and state-level immigration legislation.
Manufacturing systematics and cladistics: state of the art and generic classification
Authors: Rose-Anderssen Christen , Baldwin James , Ridgway Keith 
Published: June 2017

PurposeThe purpose of this paper is to critically evaluate the state of the art of applications of organisational systematics and manufacturing cladistics in terms of strengths and weaknesses and introduce new generic cladistic and hierarchical classifications of discrete manufacturing systems. These classifications are the basis for a practical web-based expert system and diagnostic benchmarking tool.Design/methodology/approachThere were two stages for the research methods, with eight re-iterative steps: one for theory building, using secondary and observational data, producing conceptual classifications; the second stage for theory testing and theory development, using quantitative data from 153 companies and 510 manufacturing systems, producing the final factual cladogram. Evolutionary relationships between 53 candidate manufacturing systems, using 13 characters with 84 states, are hypothesised and presented diagrammatically. The manufacturing systems are also organised in a hierarchical classification with 13 genera, 6 families and 3 orders under one class of discrete manufacturing.FindingsThis work addressed several weaknesses of current manufacturing cladistic classifications which include the lack of an explicit out-group comparison, limited conceptual cladogram development, limited use of characters and that previous classifications are specific to sectors. In order to correct these limitations, the paper first expands on previous work by producing a more generic manufacturing system classification. Second, it describes a novel web-based expert system for the practical application of the discrete manufacturing system.Practical implicationsThe classifications form the basis for a practical web-based expert system and diagnostic benchmarking tool, but also have a novel use in an educational context as it simplifies and relationally organises extant manufacturing system knowledge.Originality/valueThe research employed a novel re-iterative methodology for both theory building, using observational data, producing the conceptual classification, and through theory testing developing the final factual cladogram that forms the basis for the practical web-based expert system and diagnostic tool.
Making sense: unleashing social capital in interdisciplinary teams
Authors: Bryant Lauren H. , Freeman Sherry Booth , Daly Alan , Liou Yi-Hwa , Branon Suzanne 
Published: June 2017

PurposePrevious attempts to solve complex problems in the field of education have often focused on one disciplinary perspective. This impedes the creation of meaningful solutions and lasting change. While an interdisciplinary approach has the potential for complex problem solving, it has often proven difficult. The purpose of this paper is to apply social capital and sense-making lenses to facilitate complex problem-solving on a large, interdisciplinary, National Science Foundation funded team.Design/methodology/approachSocial network analysis (SNA) and interviews allowed for the examination of the existing underlying social structures of the project team, and the ways in which these underlying structures were impacting the team’s ability to leverage its own social capital.FindingsFindings demonstrated that decentralized, low levels of weekly and daily collaboration may constrain the team’s capacity for collective sense-making and its ability to achieve coherence around project goals.Practical implicationsUsing SNA to systematically study the underlying network structure of a team, with the intention to use that data to drive change, can allow teams to shape their networks over time to allow for sense-making and successful collaborations. It may be that, while large teams are studying their intended phenomena, they should also make time to study themselves.Social implicationsIncreasing the successfulness of large teams stands to positively impact researchers’ abilities to create workable solutions to intractable problems.Originality/valueWhile SNA is a popular approach to understanding school districts and the spread of educational innovations, this study uses SNA to understand the creation of solutions and innovations.
Dealing with multiple incompatible work-related identities: the case of artists
Authors: Hennekam Sophie 
Published: June 2017

PurposeThe purpose of this paper is to examine how artists deal with having multiple potentially incompatible work-related identities as a result of a career transition from making a living exclusively as artists to taking on additional work outside the creative industries.Design/methodology/approachIn all, 40 semi-structured in-depth interviews were conducted by telephone with artists in the Netherlands. A grounded theory approach was used to analyze the findings.FindingsFour different strategies for dealing with multiple potentially incompatible identities were identified: integration, accumulation, separation and dis-identification. The findings suggest that the informal social context, the support of rejection of important others, influenced the strategy adopted by the artists. Invalidation from the environment often leads to stress and separation or dis-identification strategies, while validation seems to lead to integration and accumulation strategies that are less psychologically straining.Practical implicationsThe findings stress the importance of the external environment. While the workers had to deal with their own psychological stress and regret about not succeeding at working exclusively as artists, they also had to create a feasible story that allowed them to “sell” their transition to others.Originality/valueCareers are becoming increasingly non-linear, and the number of workers who need to juggle multiple (potentially conflicting) work-related identities is rising. However, how workers deal with this has received only limited attention from researchers.
Rapid detection and quantification of soya bean oil and common sugar in bovine milk using attenuated total reflectance–fourier transform infrared spectroscopy
Authors: Jaiswal Pranita , Jha Shyam Narayan , Kaur Jaspreet , Hg Ramya 
Published: June 2017

Attenuated total reflectance–Fourier transform infrared spectroscopy, along with chemometrics, were used to detect and quantify soya bean oil (SO) and sugar (CS) adulteration in milk. Bovine milk was artificially adulterated with SO (0.2–2.0%; v/v) and CS (1–10%; w/v) separately. Spectra revealed significant differences in specific wavenumber regions (SO: 1450–1250 cm−1; CS: 1200–900 cm−1). Soya bean oil adulteration was best predicted in wavenumber range of 1262–1164 cm−1, using partial least square regression (coefficient of determination (R2: 0.90 and 0.88 for calibration and validation, respectively). Common sugar adulteration was best predicted in wavenumber range of 1010–910 cm−1 (R2: 0.99 for calibration and validation) using partial least square.
Factors related to successful transition planning for adolescents on the autism spectrum
Authors: Hatfield Megan , Ciccarelli Marina , Falkmer Torbjörn , Falkmer Marita 
Published: June 2017

Adolescents on the autism spectrum often have difficulties with the transition from high school to post‐school activities. Despite this, little is known about the transition planning processes for this group. This study explored predisposing, reinforcing and enabling factors related to the transition planning processes for adolescents on the autism spectrum in Australia. The PRECEDE model guided a needs assessment, in which descriptive data about transition planning processes were collected via an online questionnaire from adolescents on the autism spectrum, their parents and professionals (N = 162). Predisposing factors included: an individualised and strengths‐focused approach, and adolescent motivation, anxiety and insight. Reinforcing factors included: support and guidance, skill development and real‐life experiences. Enabling factors were: having a clear plan with a coordinated approach, scheduled meetings and clear formal documentation. Whilst some factors aligned with recommendations for transition planning for adolescents with disabilities in general, there were some autism‐specific factors. For example: anxiety, motivation and insight were important predisposing factors, and providing choice and flexibility was an enabling factor.
ssdm: An r package to predict distribution of species richness and composition based on stacked species distribution models
Authors: Schmitt Sylvain , Pouteau Robin , Justeau Dimitri , de Boissieu Florian , Birnbaum Philippe 
Published: June 2017

Abstract

There is growing interest among conservationists in biodiversity mapping based on stacked species distribution models (SSDMs), a method that combines multiple individual species distribution models to produce a community‐level model. However, no user‐friendly interface specifically designed to provide the basic tools needed to fit such models was available until now.

The “ssdm” package is a computer platform implemented in r providing a range of methodological approaches and parameterisation at each step in building the SSDM: e.g. pseudo‐absence selection, variable contribution and model accuracy assessment, inter‐model consensus forecasting, species assembly design, and calculation of weighted endemism.

The object‐oriented design of the package is such that: users can modify existing methods, extend the framework by implementing new methods, and share them to be reproduced by others.

The package includes a graphical user interface to extend the use of SSDMs to a wide range of conservation scientists and practitioners.
Hyperoxaluria, hyperglycoluria and renal oxalosis in Gilbert's potoroos (Potorous gilbertii)
Authors: Forshaw D , Horwitz AM , Ellard K , Friend JA , Greed L , Metz M 
Published: June 2017

Case reportSix Gilbert's potoroos (Potorous gilbertii) in a captive colony, five of which were closely related, died or were euthanased with severe renal disease. Clinical signs were mostly non‐specific. Renal calculi were seen on ultrasound of two affected potoroos and oxalate crystalluria was seen in two of three affected potoroos that had urine samples examined. Necropsies revealed extensive severe renal oxalosis in all affected potoroos. These findings and markedly increased concentrations of glycolate in the urine of the four affected potoroos for which it was measured, confirmed a disorder of oxalate metabolism and suggested a condition similar to primary hyperoxaluria type 1 in humans. Liver alanine : glyoxylate aminotransferase activity and intracellular location were assessed as normal in one affected potoroo, which is inconsistent with human primary hyperoxaluria type 1. Although a condition similar to human primary hyperoxaluria type 2 or 3 was not ruled out, other clinicopathological findings were not consistent with those seen in humans with these conditions. A lack of faecal oxalate‐degrading activity was observed in two affected potoroos in which it was measured, whereas oxalate‐degrading activity was variably present in healthy captive and wild potoroos.ConclusionAlthough the pathogenesis of renal oxalosis in these cases was not clear, the biochemical findings of elevated urinary oxalate and glycolate excretion indicate an abnormality of oxalate metabolism. The familial pattern of disease suggests it could be an inherited condition.
Efficacy of a commercial vaccine against different strains of rabbit haemorrhagic disease virus
Authors: Read AJ , Kirkland PD 
Published: June 2017

BackgroundThis study investigated the ability of a commercial rabbit haemorrhagic disease virus (RHDV) vaccine (Cylap®) to protect rabbits from disease caused by two different strains of the virus (v351 and K5) that are used or proposed to be used for wild rabbit control in Australia. These strains of the RHDV1 genotype belong to the ‘classical RHDV’ and ‘antigenic variant RHDVa’ subtypes, respectively.MethodsVaccinated rabbits were exposed to very high doses of the virus either by direct oral dosing or by exposure to infected rabbit livers.Results & ConclusionAll vaccinated rabbits were protected against rabbit haemorrhagic disease, indicating that the Cylap® vaccine is effective against both strains of the virus under experimental conditions.
Preclinical evaluation of the BET bromodomain inhibitor BAY 1238097 for the treatment of lymphoma
Authors: Bernasconi Elena , Gaudio Eugenio , Lejeune Pascale , Tarantelli Chiara , Cascione Luciano , Kwee Ivo , Spriano Filippo , Rinaldi Andrea , Mensah Afua A. , Chung Elaine , Stathis Anastasios , Siegel Stephan , Schmees Norbert , Ocker Matthias , Zucca Emanuele , Haendler Bernard , Bertoni Francesco 
Published: June 2017

SummaryThe epigenome is often deregulated in cancer and treatment with inhibitors of bromodomain and extra‐terminal proteins, the readers of epigenetic acetylation marks, represents a novel therapeutic approach. Here, we have characterized the anti‐tumour activity of the novel bromodomain and extra‐terminal (BET) inhibitor BAY 1238097 in preclinical lymphoma models. BAY 1238097 showed anti‐proliferative activity in a large panel of lymphoma‐derived cell lines, with a median 50% inhibitory concentration between 70 and 208 nmol/l. The compound showed strong anti‐tumour efficacy in vivo as a single agent in two diffuse large B cell lymphoma models. Gene expression profiling showed BAY 1238097 targeted the NFKB/TLR/JAK/STAT signalling pathways, MYC and E2F1‐regulated genes, cell cycle regulation and chromatin structure. The gene expression profiling signatures also highly overlapped with the signatures obtained with other BET Bromodomain inhibitors and partially overlapped with HDAC‐inhibitors, mTOR inhibitors and demethylating agents. Notably, BAY 1238097 presented in vitro synergism with EZH2, mTOR and BTK inhibitors. In conclusion, the BET inhibitor BAY 1238097 presented promising anti‐lymphoma preclinical activity in vitro and in vivo, mediated by the interference with biological processes driving the lymphoma cells. Our data also indicate the use of combination schemes targeting EZH2, mTOR and BTK alongside BET bromodomains.
Fibrinogen concentration and use of fibrinogen supplementation with cryoprecipitate in patients with critical bleeding receiving massive transfusion: a bi‐national cohort study
Authors: McQuilten Zoe K. , Bailey Michael , Cameron Peter A. , Stanworth Simon J. , Venardos Kylie , Wood Erica M. , Cooper D. James 
Published: June 2017

SummaryWe aimed to compare hypofibrinogenaemia prevalence in major bleeding patients across all clinical contexts, fibrinogen supplementation practice, and explore the relationship between fibrinogen concentrations and mortality. This cohort study included all adult patients from 20 hospitals across Australia and New Zealand who received massive transfusion between April 2011 and October 2015. Of 3566 patients, 2829 (79%) had fibrinogen concentration recorded, with a median first and lowest concentration of 2·0 g/l (interquartile range [IQR] 1·5–2·7) and 1·8 g/l (IQR 1·3–2·4), respectively. Liver transplant (1·7 g/l, IQR 1·2–2·1), trauma (1·8, IQR 1·3–2·5) and vascular surgery (1·9 g/l, IQR 1·4–2·5) had lower concentrations. Total median fibrinogen dose administered from all products was 7·3 g (IQR 3·3–13·0). Overall, 1732 (61%) received cryoprecipitate and 9 (<1%) fibrinogen concentrate. Time to cryoprecipitate issue in those with initial fibrinogen concentration <1 g/l was 2·5 h (IQR 1·2–4·3 h). After adjustment, initial fibrinogen concentration had a U‐shaped association with in‐hospital mortality [adjusted odds ratios: fibrinogen <1 g/l, 2·31 (95% confidence interval (CI) 1·48–3·60); 1–1·9 g/l, 1·29 (95% CI 0·99–1·67) and >4 g/l, 2·03 (95% CI 1·35–3·04), 2–4 g/l reference category]. The findings indicate areas for practice improvement including timely administration of cryoprecipitate, which is the most common source of concentrated fibrinogen in Australia and New Zealand.
Clinical heterogeneity of diffuse large B cell lymphoma following failure of front‐line immunochemotherapy
Authors: Farooq Umar , Maurer Matthew J. , Thompson Carrie A. , Thanarajasingam Gita , Inwards David J. , Micallef Ivana , Macon William , Syrbu Sergei , Lin Tasha , Lin Yi , Ansell Stephen M. , Nowakowski Grzegorz S. , Habermann Thomas M. , Cerhan James R. , Link Brian K. 
Published: June 2017

SummaryThis study aimed to describe the patterns of care and outcomes of diffuse large B cell lymphoma (DLBCL) after failure of front line anthracycline‐based immunochemotherapy (IC). Patients with newly diagnosed lymphoma were prospectively enrolled in Molecular Epidemiology Resource (MER) of the University of Iowa/Mayo Clinic Lymphoma Specialized Program of Research Excellzence. All DLBCL and primary mediastinal B‐cell lymphoma (PMBL) patients treated with front‐line anthracycline‐based IC were followed for relapse. Patients with relapse on follow‐up and subsequently retreated were included in this analysis. 1039 patients received anthracycline‐based IC between 2002 and 2012, of which 244 relapsed and were subsequently retreated. Across all therapies, overall survival at 4 years (OS4) from relapse was 28% and 103 patients ultimately underwent autologous haematopoietic cell transplant (autoHCT) with OS4 from autoHCT of 51%. Patients relapsing after 12 months from initial diagnosis had OS4 of 47% but those with a transient or no response to initial therapy had OS4 of only 13%. Outcomes of relapsed or refractory DLBCL differ substantially when categorized by response to initial therapy, timing of relapse and opportunity to undergo autoHCT. The design and interpretation of uncontrolled trials should account for this heterogeneity in patients with relapsed DLBCL.
Increased fracture risk in plasma cell dyscrasias is associated with poorer overall survival
Authors: McIlroy Graham , Mytton Jemma , Evison Felicity , Yadav Punit , Drayson Mark T. , Cook Mark , Pratt Guy , Cockwell Paul , Pinney Jennifer H. 
Published: June 2017

SummaryPathological fractures are a common complication of plasma cell dyscrasias (PCD) and are associated with significant morbidity. Routine use of bisphosphonates over the past decade has aimed to reduce the risk of fractures in patients with multiple myeloma, but despite this, fractures continue to represent a significant burden of disease. In this study we report the fracture rate of hospital in‐patients with PCD in England. Data from the national registry Hospital Episode Statistics between 2001 and 2015 were used to determine fracture rate and its effect on overall survival. Fracture rates were 17·8 times higher than the general population in the first year after admission with PCD, and remained elevated for up to 10 years after first admission. The increased fracture risk preceded the first admission with PCD and, conversely, the incidence of PCD increased after admission with one or more fractures. Overall survival is improving with PCD, however poorer survival is found in patients with a preceding fracture (Hazard ratio 1·20). Despite widespread bisphosphonate use, fractures remain common in PCD, and are associated with poorer outcomes.