bluuebunny/crossref_metadata_2025_split huggingface dataset:
Factors Affecting Cognitive Impairment in Chronic Kidney Disease Patients
Authors: Muhammad Shahbaz Pervaiz  , Anees Muhammad , Irfan Elahi  , Noman Butt  , Saba Tauqeer  
Published: September 2024

Background: Cognitive impairment (CI) is frequently observed in patients with chronic kidney disease (CKD). There are many factors associated with CI in CKD patients in international studies but no study has been done previously in Pakistan on this important issue.
Objective: The objective of this study was to determine factors affecting CI in CKD patients
Methods: This observational study was carried out in Nephrology Department of Mayo Hospital, Lahore (January 2023 to March 2023). All CKD patients, regardless of cause, were included while patients on renal replacement therapy (RRT) were excluded. The Mini-Mental State Examination (MMSE) tool was employed to evaluate cognitive function.
Results: A total of 100 patients were enrolled. The average age of the patients was 50.44±12.58 years, with diabetes mellitus (DM) being the leading cause of CKD in 53(53.0%) patients. CI was identified in 61(61.0%) patients while mild and moderate CI was found in 34 (34%) and 27 (27 %) respectively. Female gender (RR=1.40, 95%CI=1.01-193, p=0.042), low estimated glomerular filtration rate (eGFR) (RR=1.92, 95% CI=1.27-2.91, p=0.002), anemia (RR=1.23, 95% CI=1.01-1.50, p=0.003) and lower educational qualifications (RR= 3.39, 95% CI=1.65-6.94, p=<0.001) were found significant factors of CI. Increasing age was associated with increased CI severity (r=-0.110, p=0.278) while eGFR has positive correlation with CI score (r=0.271,p=0.006) .
Conclusion: CI was frequently prevalent among patients with CKD. Female gender, low eGFR, anemia and low level of education were independent predictors of CI in CKD patients. Advancing age has negative correlation while GFR has positive correlation with CI score.
Correlation of Neuroinflammation and Therapeutic Targets in Perioperative Neurocognitive Disorders
Authors: Khan Fahad , Verma Meenakshi , Rautela Indra , Upadhye Vijay Jagdish , Pandey Pratibha , Kumar Rahul 
Published: September 2024

Abstract:
Perioperative Neurocognitive (PND) disorders represent a prevalent complication
among geriatric patients, manifested in diverse forms of cognitive impairment following anesthesia
and surgical procedures. Even though the exact origin of PND disorders is still unknown,
neuroinflammation has been identified as a significant contributing factor, particularly in older
patients. Hence, this review aims to provide a deeper insight into the underlying mechanism and
associated potent therapeutic targets for the efficient management of perioperative neurocognitive
disorders. Many factors, such as PRRs, chemokine receptors, immunoglobulin superfamily
receptors, and purinergic receptors, are involved in the development and occurrence of perioperative
neurocognitive disorders to varying degrees and may be valuable biomarkers for their effective
management. Here, we present a comprehensive overview of the involvement of neuroinflammation
in PND disorders, including their onset and possible therapeutic targets. This
review would benefit future researchers in elucidating a better therapeutic approach for the management
of perioperative neurocognitive disorders. We have also briefly outlined the clinical
trials associated with Postoperative neurocognitive disorders in the last section of the review.
Altogether, this review would help the researchers investigate better therapeutics for the management
of PND disorders.
Ultrasound Evaluations of Ankle and Foot Muscles in Diabetic Peripheral Neuropathy Systematic Review with Meta-Analysis
Authors: S. Sharath , Kadavigere Rajagopal , Maiya G. Arun 
Published: September 2024

Background:
Diabetic peripheral neuropathy (DPN) is the prevalent microvascular
complication of diabetes mellitus (DM). 30-50% of diabetics are likely to be affected by DPN. It
significantly impacts the skeletal muscles, resulting in an accelerated loss of muscle mass. The
objective of this systematic review was to evaluate the ankle and foot muscle changes in diabetic
peripheral neuropathy using ultrasound.

Method:
A comprehensive search was conducted in Scopus, Embase, and PubMed databases,
which yielded 64 studies, out of which 5 studies are included in this meta-analysis.

Result:
The meta-analysis shows that the thickness and cross-section area of the extensor digitorum
brevis muscle are reduced in DPN as compared to the control group with p-value<0.004
and p-value<0.001, respectively. The thickness of MIL muscle was also smaller in DPN
p-value=0.02. Similarly, the thickness and CSA of AH muscle are also reduced in DPN patients
compared to the control group, with p-values of 0.21 and 0.14.

Conclusion:
Meta-analysis reveals that diabetic peripheral neuropathy (DPN) patients have reduced
foot muscle thickness and cross-sectional area (CSA) compared to controls without neuropathy.
This highlights the importance of ultrasound in detecting muscle atrophy early in diabetic
patients since it provides objective measures beyond traditional screening with its real-time
and non-invasive nature.
The hormonal status of male combatants depending on the volume of body wounding
Authors: Lurin I.A. , Khoroshun E.M. , Seliukova N.Yu. , Rekhviashvili M. , Makarov V.V. , Boiko M.O. , Nehoduiko V.V. , Misiura K.V. 
Published: September 2024

Background. The massive russian military aggression against Ukraine has been continuing from February 24, 2022, and has caused the number of individuals who received combat wounds and psychological trauma to be significantly increased. After experienced traumatic events, the psychological changes appear first. They further strongly impact the physical condition of people. The acute stress which occurred after body injuring can further lead to the altering in the endocrine system. It is necessary to point out that during military conflict in Ukraine, the studying of hormonal influence on the particularities and rate of wound healing hasn’t been carried out. Therefore, the purpose of this work was to determine the connection between wound volume and altering of some hormone levels in blood serum at different stages of wound healing process in male combatants. Materials and methods. One hundred and twenty male combatants who were divided into 4 groups of 30 individuals depending on the wound volume have taken part in our investigation. The first group was the minor injuries; the second group — the moderate wounding; the third group was the serious injuries, and the fourth group (controls) included not wounded combatants. The certain periodization has been used depending on the processes which occur in the body in particular period: days 1–3, 4–5 and day 14 after wounding. The average age of patients was 34.2 ± 4.3 years, average body mass was 78.0 ± 3.5 kg. The concentrations of human growth hormone, testosterone, adrenocorticotropic hormone, aldosterone, thyroid-stimulating hormone, free triiodothyronine, free levothyroxine and dehydroepiandrosterone sulfate were evaluated. Results. The activating of practically all chains and complexes of endocrine system is its usual reaction to the injury. The main links between wound volume and serum hormone levels of combatants at the different stages of wound healing process have been revealed in our research. Conclusions. The metabolic response which occurs in human body independently of trauma severity is associated with necessity of the functioning of all organs and systems at the highest level in order to save lives of victims. The altering of all kinds of metabolism occurs. The metabolic signs of urgent adaptation are formed in the acute period of wound healing process related to katabolic processes. After that, the normalization of homeostasis with activating of anabolic processes gradually occurs. A positive correlation was found between the hormone levels and severity and term of injuring of male combatants. The continuation of monito­ring the hormonal status of male combatants with the involvement of large number of participants and detailing of wound localization, endocrinological history, neurological and mental status, hemodynamic parameters and the system of homeostasis is appropriate.
A comprehensive approach to rehabilitation interventions in patients with limb amputation and metabolic disorders in the multidisciplinary team of the Charitable Organization “Charitable Fund “Superhumans”
Authors: Farmaha M.L. , Vilenskyi A.B. , Aleynik V.A. 
Published: September 2024

Background. Limb loss inevitably leads to changes in the physical, social, and mental domains that trigger a cascade of events: a more sedentary lifestyle, decreased ability to self-care, and increased use of health services. In addition, limb loss can negatively affect metabolic regulation and contribute to an increased risk of obesity and all associated metabolic consequences. The aim of the study was to justify the role of doctors of therapeutic specialties in the multidisciplinary team of the rehabilitation center based on the study of patients’ concomitant diseases. Materials and methods. The study included 379 patients from the Charitable Organization “Charity Fund “Superhumans”. They had an amputation and received a prosthesis and/or underwent rehabilitation from July 2023 to March 2024. Among participants, there were 9 women and 370 men, with an average age of 37.22 ± 9.74 years. Results. The role of doctors of therapeutic specialties in the multidisciplinary team of the rehabilitation center is substantiated based on the study of concomitant diseases of patients who have undergone amputation of one or more limbs. The study identified the following comorbidities: overweight (193 cases, 50.9 %), hypertension (108 cases, 28.5 %), liver damage of viral and non-viral origin (71 cases, 18.7 %), dyslipidemia (44 cases, 11.6 %), chronic gastritis (19 cases, 5.0 %), gastroesophageal reflux disease (15 cases, 4.0 %), rhythm disturbances (mainly sinus tachycardia or bradycardia) (14 cases, 3.7 %), chronic pancreatitis (11 cases, 2.9 %), duodenal ulcer (10 cases, 2.6 %), chronic cholecystitis (9 cases, 2.4 %), urolithiasis (4 cases, 1.1 %), chronic cystitis (4 cases, 1.1 %), chronic pyelonephritis (3 cases, 0.8 %), atrioventricular block (3 cases, 0.8 %), chronic obstructive pulmonary disease (2 cases, 0.5 %), bronchial asthma (2 cases, 0.5 %), autoimmune thyroiditis (2 cases, 0.5 %), nodular goiter (1 case, 0.3 %). Conclusions. Based on data obtained, the risks of progression of metabolic disorders and comorbidities in patients with limb amputations were determined.
Membangun Komunitas Melalui Keunggulan Kompetitif Kelompok Wanita Tani Kenanga: Kolaborasi dan Partisipasi
Authors: Nugroho Albertus Henri Listyanto , Nursetyo Marcellino Khrisna , Lubis Rosalin Putri 
Published: September 2024

Abstrak: Kelompok Wanita Tani (Kenanga) merupakan kelompok berbasis masyarakat di Padukuhan yang bertujuan untuk meningkatkan perekonomian rumah tangga. Dengan keunggulan kompetitif, antara lain semangat, antusiasme, dan letak geografis, dapat membawa masyarakat mencapai tujuannya. Layanan ini menggunakan metode service-learning yang mengutamakan kerjasama antara mitra dan pelayan. Prinsip-prinsip keterlibatan mitra, pertukaran pengalaman teoritis dan praktis, serta pertukaran pengalaman dan publikasi telah diselesaikan dalam pengabdian ini. Kolaborasi artinya mitra mempunyai banyak pengalaman dalam hal-hal praktis, sedangkan pelayan mempunyai pengalaman dalam hal-hal teoritis. Melalui layanan ini diharapkan terjadi pertukaran pengalaman dan manfaat antar mitra. Akhir kata, pengabdian ini dapat mendokumentasikan semangat dan antusiasme yang dihasilkan melalui naskah ini. Harapannya, naskah ini dapat menginspirasi peningkatan kapasitas melalui keunggulan kompetitif komunitas. Abstract: The Women's Farmers Group (Kenanga) is a community-based in Padukuhan which aims to improve the household economy. With competitive advantages, including passion, enthusiasm, and geographical location, it can bring the community to achieve its goals. This service uses a service-learning method that prioritizes collaboration between partners and servants. The principles of partner involvement, exchange of theoretical and practical experiences, and exchange of experiences and publications have been resolved in this service. Collaboration means that partners have much experience in practical matters, while servants have experience in theoretical matters. Through this service, it is hoped that there will be an exchange of experiences and benefits between partners. Finally, this dedication can document the enthusiasm and enthusiasm generated through this manuscript. The hope is that this manuscript will inspire capacity building through community competitive advantage.
ANALISIS REAKSI PASAR MODAL TERHADAP PENGUMUMAN KENAIKAN HARGA BBM PADA 3 SEPTEMBER 2022
Authors: Anggriawan Bayu , Candradewi Ni Made Reina 
Published: September 2024

Teori Pasar Efisien merupakan konsep yang bertujuan untuk melihat reaksi pasar terhadap kandungan informasi yang terdapat dalam suatu peristiwa. Penelitian ini bertujuan untuk mengetahui reaksi pasar terhadap peristiwa pengumuman kenaikan harga BBM pada 3 September 2022. Terdapat 2 (dua) variabel yang digunakan dalam penelitian ini, yaitu average abnormal return dan average trading volume activity. Penelitian ini dilakukan pada perusahaan yang terdaftar dalam sektor transportasi dan logistik (IDXTRANS) di Bursa Efek Indonesia (BEI). Jumlah sampel yang digunakan dalam penelitian ini adalah sebanyak 22 perusahaan yang dipilih dengan menggunakan purposive sampling. Penelitian ini menggunakan One Sample T-Test dan One Sample Wilcoxon Signed Rank Test sebagai teknik analisis data. Berdasarkan hasil pengujian, didapatkan bahwa terdapat average abnormal return dan average trading volume activity yang signifikan di sekitar periode peristiwa, sehingga hal ini mengindikasikan bahwa peristiwa pengumuman kenaikan harga BBM pada 3 September 2022 memiliki kandungan informasi yang dapat membuat pasar bereaksi.
SANKSI PERPAJAKAN MEMODERASI PENGARUH PENERAPAN SELF ASSESSMENT SYSTEM DAN WHISTLEBLOWING SYSTEM TERHADAP KEPATUHAN WPOP
Authors: Anggun Tyasmini Ni Nyoman , Hasibuan Henny Triyana 
Published: September 2024

Tinggi maupun rendahnya kesadaran dari masyarakat menjadi faktor penting dalam tingkat penerimaan jumlah pajak dari tahun ke tahun. Tingkat kepatuhan wajib pajak orang pribadi di Kota Singaraja belum mencapai 50 persen dari jumlah WPOP yang terdaftar. Penelitian ini dilaksanakan untuk mendapatkan bukti empiris mengenai pengaruh penerapan self assessment system dan whistleblowing system terhadap kepatuhan wajib pajak orang pribadi yang dimoderasi oleh sanksi perpajakan di Kota Singaraja. Data penelitian dikumpulkan melalui kuesioner dengan responden penelitian adalah WPOP yang terdaftar di KPP Pratama Singaraja. Metode penentuan sampel menerapkan accidental sampling, dengan sampel sebanyak 100 responden. Pengkolektifan data dilaksanakan melalui kuesioner. Teknik kajian yang diterapkan ialah regresi linier berganda dan Moderated Regression Analysis (MRA). Dari perolehan penelitian memperlihatkan bahwa penerapan self assessment system dan whistleblowing system berpengaruh negatif terhadap kepatuhan WPOP di KPP Pratama Singaraja. Perolehan penelitian ini juga membuktikan bahwa sanksi perpajakan mampu memperkuat hubungan negatif dari pengaplikasian self assessment system dan whistleblowing system terhadap kepatuhan WPOP di KPP Pratama Singaraja. Implikasi penelitian ini yakni memperluas pengetahuan di bidang ekonomi maupun akuntansi yang berkaitan dengan perpajakan khususnya mengenai self assessment system, whistleblowing system, dan sanksi perpajakan.
REPUTASI KAP, KOMPLEKSITAS OPERASI, SOLVABILITAS, DAN AUDIT DELAY
Authors: Ersamayoni Wibawa Gusti Ayu Denis , Harta Mimba Ni Ptu Sri 
Published: September 2024

Ketepatan waktu publikasi laporan keuangan merupakan faktor penting untuk mengukur nilai informasi keuangan suatu perusahaan. Fenomena keterlambatan publikasi laporan keuangan masih ditemukan pada perusahaan go public. Penelitian bertujuan untuk memberikan bukti empiris mengenai pengaruh reputasi Kantor Akuntan Publik, kompleksitas operasi, dan solvabilitas terhadap audit delay. Penelitian ini dilakukan pada perusahaan sektor barang konsumen non-primer yang terdaftar di Bursa Efek Indonesia tahun 2020-2021. Data penelitian menggunakan data sekunder berupa laporan keuangan auditan yang diperoleh melalui situs Indonesian Stock Exchange (IDX). Jumlah sampel yang diambil sebanyak 134 perusahaan dengan teknik non-probability sampling. Teknik analisis data yang digunakan adalah regresi linear berganda. Hasil penelitian menunjukkan reputasi Kantor Akuntan Publik berpengaruh negatif signifikan terhadap audit delay, kompleksitas operasi berpengaruh positif tidak signifikan terhadap audit delay, dan solvabilitas berpengaruh negatif tidak signifikan terhadap audit delay. Hasil penelitian memberikan implikasi terhadap teori agensi terkait hubungan keagenan antara manajer dengan pemilik, dan implikasi praktis bagi perusahaan untuk mempertimbangkan pemilihan Kantor Akuntan Publik yang bereputasi baik serta bisa memberikan dan menjelaskan berbagai data yang diperlukan auditor guna mempercepat proses audit sehingga publikasi laporan keuangan dapat dilakukan tepat waktu.
DETERMINAN TINGKAT KEMISKINAN DI INDONESIA
Authors: Klarasanti Anggraini , Bendesa I Komang Gde 
Published: September 2024

Tujuan dari penelitian ini yaitu, 1) untuk menganalisis pengaruh angka harapan hidup, rata-rata lama sekolah, pengeluaran per kapita, jumlah penduduk, tingkat pengangguran, dan pandemi Covid-19 terhadap tingkat kemiskinan di Indonesia. 2) untuk menganalisis perbedaan tingkat kemiskinan, angka harapan hidup, rata-rata lama sekolah, pengeluaran per kapita, jumlah penduduk, dan tingkat pengangguran antara Kawasan Barat Indonesia dan Kawasan Timur Indonesia. Jumlah pengamatan yang digunakan dalam penelitian ini sebanyak 408 pengamatan. Data yang digunakan merupakan data sekunder. Penelitian diuji menggunakan teknik analisis regresi data panel dengan model estimasi yang terpilih yaitu fixed effect model. Hasil analisis penelitian ini yaitu, 1) Angka harapan hidup, rata-rata lama sekolah, pengeluaran per kapita, jumlah penduduk, tingkat pengangguran, dan pandemi Covid-19 berpengaruh signifikan terhadap tingkat kemiskinan. 2) Angka harapan hidup, pengeluaran per kapita, dan jumlah penduduk berpengaruh negatif dan signifikan terhadap tingkat kemiskinan, rata-rata lama sekolah dan tingkat pengangguran tidak berpengaruh terhadap tingkat kemiskinan. 3) Terdapat perbedaan yang signifikan tingkat kemiskinan, angka harapan hidup, rata-rata lama sekolah, pengeluaran per kapita, jumlah penduduk, dan tingkat pengangguran antara Kawasan Barat Indonesia dan Kawasan Timur Indonesia.
PENGARUH FLEKSIBILITAS KEUANGAN, UKURAN PERUSAHAAN DAN STRUKTUR MODAL TERHADAP NILAI PERUSAHAAN
Authors: Dewi Putu Ayu Ersa Tresna , Candraningrat Ica Rika 
Published: September 2024

Keinginan investor untuk melakukan penanaman modal pada perusahaan tergantung pada nilai perusahaan. Penelitian ini bertujuan untuk menganalisis pengaruh fleksibilitas keuangan dan ukuran perusahaan terhadap nilai perusahaan dengan struktur modal sebagai variabel mediasi. Penelitian ini dilakukan pada perusahan sub sektor makanan dan minuman di Bursa Efek Indonesia (BEI) pada tahun 2019-2021. Sebanyak 28 sampel ditentukan dengan purposive sampling. Hasil penelitian ini menunjukkan bahwa fleksibilitas keuangan berpengaruh positif terhadap struktur modal dan nilai perusahaan, ukuran perusahaan tidak berpengaruh terhadap struktur modal, ukuran perusahaan berpengaruh positif terhadap nilai perusahaan, struktur modal tidak berpengaruh terhadap nilai perusahaan, dan struktur modal tidak dapat memediasi fleksibilitas keuangan dan ukuran perusahaan terhadap nilai perusahaan.
ALTERNATIVE DEVELOPMENT IN LATIN AMERICA AS A COUNTER HEGEMONY TO NEOLIBERALISM
Authors: Setiyaningsih Dewi , Windiani Reni , Hasibuan Eka Maria 
Published: September 2024

Latin America has an interesting economic development dynamic. As an effort to get out from western imperialism, these countries are aggressively implementing an alternative economic system called Import Substitution Industrialization (ISI). However, this system did not last long and led to a crisis so that countries in Latin America inevitably adopted neoliberal economics. However, neoliberal development has created inequality between the people and few elites. In such a situation, many countries in Latin America are trying to formulate alternative development recipes in order to get out of economic neoliberalism which has a negative impact on their social and political order. This paper will try to analyze development alternatives in Latin America using the counter hegemony concept developed by Antonio Gramsci. As a case study, this paper takes two examples of Latin American countries that are seeking development alternatives, namely Brazil and Venezuela. Even though they are both against the hegemony of neoliberal development, each of them has different patterns, where Brazil is more compromising, while Venezuela is more radically revolutionary. This difference also causes the success or failure of alternative development in each of these countries.
Repercussions of a pandemic outbreak on the motor and linguistic development of infant from 18 to 24 months
Authors: Hermes Letícia , Nunes Sabrina Felin , Moraes Denis Altieri de Oliveira , Nunes Nathália Rieder , Simoni Simone Nicolini De , Weinmann Angela Regina Maciel , Soares Márcia Keske 
Published: September 2024

Objective: To evaluate and compare the motor and linguistic development of neurotypical infantren aged 18 to 24 months, who were born in a period of pandemic outbreak (Study Group - SG), with the Control Group (CG), that were evaluated pre-pandemic. Iniciar com o verbo no infinitivo, de forma clara quais são os objetivos do trabalho. Methods: Analytical cross-sectional study, the data collection was carried out using the collection instruments used: interviews with parents and a self-completed questionnaire; Hearing Assessment; in addition to this, cognitive screening and complete batteries of motor and language scales from the Bayley Scales of Infant and Toddler Development®, Third Edition (Bayley III), were used. Results: A total of 44 infants participated in the study (22 in the Study Group - SG, evaluated in the post-pandemic period; and 22 in the Control Group - GC, evaluated in the pre-pandemic period). The SG showed a tendency towards an advantage over the CG in language-related outcomes, despite possible restrictions associated with social distancing and the use of masks. On the other hand, the CG performed better in terms of gross motor skills, possibly associated with circulation restrictions and increased use of screen devices. The maternal schooling and family income differed between groups, being favorable to the SG, which may have represented protective factors, attenuating the restrictive effects of social distancing measures and minimizing greater impacts on this sample. Conclusion: The studied sample (SG) that experienced the restrictions imposed by the pandemic outbreak may have been protected by other factors such as higher family income and maternal education.