bluuebunny/crossref_metadata_2025_split huggingface dataset:
Whole‐body MRI for staging prostate cancer: a narrative review
Authors: Fang Andrew M. , Gregg Justin R. , Pettaway Curtis , Ma Jingfei , Szklaruk Janio , Bathala Tharakeswara K. , Surasi Devaki Shilpa S. , Chapin Brian F. 
Published: September 2024

ObjectiveTo present a narrative review regarding the diagnostic accuracy of whole‐body magnetic resonance imaging (WBMRI) in staging patients with high‐risk prostate cancer (HRPCa) and compare it to established imaging modalities.MethodsA narrative review was carried out using PubMed using the following keywords: ‘whole body’, ‘magnetic resonance imaging’, ‘MRI’, ‘prostate cancer’, ‘risk stratification’, and ‘staging’. Articles that evaluated WBMRI as the imaging modality to stage patients with HRPCa were included, while studies that solely assessed for biochemical recurrence or metastatic disease progression were excluded.ResultsIn the evaluation of lymphatic metastases, WBMRI has demonstrated a comparable, if not improved, sensitivity and specificity compared to conventional imaging of computed tomography (CT). Furthermore, WBMRI demonstrates improved sensitivity and specificity in detecting bone metastases compared to bone scintigraphy (BS). However, with advent of prostate‐specific membrane antigen (PSMA) radioligands for positron emission tomography (PET), the diagnostic performance of WBMRI to detect metastatic disease appears inferior.ConclusionsThe diagnostic capabilities of WBMRI exceed that of conventional imaging of CT and BS in detecting metastatic disease in patients with HRPCa. However, WBMRI does not perform as well as PSMA PET/CT. Further study on cost comparisons between WBMRI and PSMA PET/CT are needed, as well as evaluations of combined PSMA PET/MRI are needed.
Microvascular effects of a mixed meal tolerance test: a model validation study
Authors: van Kraaij Sebastiaan J. W. , Eveleens Maarse Boukje Charlotte , Hoevenaars Femke P. M. , Warnke Ines , de Kam Marieke L. , Moerland Matthijs , Gal Pim 
Published: September 2024

AbstractPurposeEndothelial dysfunction is a pathophysiological change preceding many cardiovascular events. Measuring improvements of endothelial function is challenging when function is already optimal, which may be remediated using a physiological challenge. This study aimed to determine whether imaging assessments can detect microvascular effects of a mixed meal tolerance test (MMTT).MethodsTwenty healthy volunteers (age ≥45 and ≤70 years) underwent two MMTTs at the beginning (Day 1) and end (Day 84) of a twelve‐week period. Imaging methods included laser speckle contrast imaging (LSCI) combined with post‐occlusive reactive hyperaemia (PORH) and local thermal hyperaemia (LTH) challenges, passive leg movement ultrasonography (PLM), and sidestream dark field microscopy (SDFM). Measurements were conducted pre‐MMTT and at 5 timepoints post‐MMTT for PLM and SDFM and 3 timepoints post‐MMTT for PORH and LTH.ResultsNo consistent effects of the MMTT were detected on LSCI LTH, PLM and SDFM endpoints. LSCI PORH maximum perfusion was significantly suppressed 46, 136, and 300 min post‐MMTT administration on Day 1, while residual perfusion decreased significantly 46 and 136 min post‐MMTT on Day 1. However, when repeated on Day 84, PORH endpoints were not significantly affected by the MMTT.ConclusionSDFM, PLM and LSCI LTH endpoints displayed high intra‐subject variability and did not detect consistent effects of MMTT. LSCI PORH endpoints displayed the lowest intra‐subject variability of all assessed endpoints and were affected by the MMTT on Day 1, but not on Day 84. Further standardization of methods or more robust challenges to affect vascular endpoints may be needed.
Long‐term cognitive function changes with non‐vitamin K oral anticoagulants in older patients with atrial fibrillation. A multicenter cohort study
Authors: Armentaro Giuseppe , D'Arrigo Graziella , Pastori Daniele , Crudo Giulia , Daidone Mario , Soraci Luca , Pastura Carlo Alberto , Divino Marcello , Pitino Annalisa , Gori Mercedes , Tripepi Giovanni , Imbalzano Egidio , Corsonello Andrea , Pignatelli Pasquale , Andreozzi Francesco , Tuttolomondo Antonino , Sciacqua Angela 
Published: September 2024

AbstractBackgroundAtrial fibrillation is associated with several comorbidities, particularly cognitive impairment and dementia, especially in older patients. Non‐vitamin K oral anticoagulants (NOACs) or vitamin K antagonists (VKAs) were used to prevent thromboembolic events. However, data on the real benefit of these drugs on cognitive function decline remains controversial. In this study we evaluated the effect of NOACs compared to VKAs on the absolute and relative decline in cognitive function over time.MethodsNine hundred and eighty‐three older patients with nonvalvular AF were enrolled (76 ± 6 years; 291 on VKAs and 692 on NOACs). The cognitive function was assessed with Mini Mental State examination (MMSE) score. The between‐arms difference of cognitive evolution over time was investigated by Linear Mixed Models and group‐based trajectory model analyses.ResultsIn the whole multicenter observational study, after a long follow‐up of 7.2 ± 3.4 years, the patients of the NOACs versus VKAs group had lowest absolute reduction of the MMSE score between baseline and follow‐up (−0.3 ± 0.03 vs.−1.7 ± 0.1, p < 0.001). After stratification into five subgroups according to trajectories of MMSE score over time, the probability to belong to trajectories with lower decline in cognitive functions was higher in patients on NOACs than in those on VKAs (3.93–13.88 times).ConclusionIn older patients with atrial fibrillation, the use of NOACs was associated with a smaller decline of cognitive function over time compared to the VKAs, regardless that patients in the NOACs group were older and with a higher burden of comorbidities.
Low vitamin C status and hypermobility‐related disorders in patients with bleeding disorder of unknown cause
Authors: Leinøe Eva , Fridriksdottir Halla , Rasmussen Andreas Ørslev , Funding Eva , Sørensen Anne Louise Tølbøll , Kampmann Peter , Lykkesfeldt Jens , Rossing Maria 
Published: September 2024

AbstractIntroductionBleeding disorder of unknown cause (BDUC) is a challenging diagnosis that predominantly affects women. Previous investigations into connective tissue disorders (CTD) and vitamin C have not been conducted.AimTo examine the association between hypermobility‐related disorders, vitamin C status and BDUC.MethodsPatients were selected following laboratory and genetic screening that yielded negative results for known hemostasis disorders. Sixty patients with BDUC and an ISTH BAT score ≥ 10 underwent clinically examination for skin hyperextensibility and for hypermobility assessed by Beighton score. Vitamin C was analyzed by high‐performance liquid chromatography. Genetic screening for causal variants in 42 CTD genes was performed.ResultsThe majority of patients were female (56/60). Median ISTH BAT score was 13 (range 10–23). Beighton score was positive in 29/60 patients compared to 1/20 healthy controls (HC) (p < .001). Hyperextensive skin was observed in (18/60) patients, and none (0/20) of the HC (p = .0041). Ten patients met the clinical diagnostic criteria for hypermobile Ehlers–Danlos syndrome (hEDS), and one patient was diagnosed with Noonan syndrome. Genetic screening excluded various subtypes of EDS with known genetic backgrounds. Average vitamin C level was adequate, but lower than in HC (55.9 vs. 70.4 μmol/L; p = .001). Suboptimal, or low vitamin C were identified in 19/60 compared to 1/20 HC (p = .018).ConclusionOur study demonstrates that BDUC is frequently associated with hypermobility disorders and low vitamin C status. Our results could pave the way for a randomized study of vitamin C supplementation in patients with BDUC.
Effects of NaCl/KCl ratios on structural and properties changes in soy‐potato protein mixed gel
Authors: Sun Ying , Wang Long , Lu BingLin , Zhou Bin , Liu Shen , Chen Fenglian , Jiang Lianzhou , Zhao Juyang , Zhu Xiuqing 
Published: September 2024

SummaryTo reduce the sodium salt content in protein gel‐based foods, this study investigated the effects of different Na‐K ratios on the gelation properties and structural changes of soy protein isolate (SPI) and potato protein isolate (PPI) composite gels. The results showed that the composite gel properties were further enhanced with increasing Na‐K ratio in the SPI/PPI gel system. Specifically, when the Na‐K ratio was 1:1, the SPI/PPI composite gel exhibited the highest gel strength, gel elasticity, WHC, storage modulus (G′), and β‐sheet content, whereas the α‐helix content and β‐turn content were the lowest. Scanning electron microscopy images revealed a dense and uniform network structure of the composite gel. The addition of low concentrations of Na+ and K+ improved the network structure and water‐holding capacity of the SPI/PPI gel during the heat‐induced gelation process. However, excessively high Na‐K ratios weakened the gel properties.
Thiourea Supplementation Improves Drought Stress Response of Ridge‐Sown and Mulch‐Applied Rainfed Maize (Zea mays L.) via Improved Leaf Source to Grain Sink Dynamics
Authors: Singh Talveer , Sandhu Parminder Singh , Darrouzet‐Nardi Anthony 
Published: September 2024

ABSTRACTIn regions of South Asia where rainfed maize is grown, effective crop management during drought is essential for maximising yield. A variety of water‐conserving planting practices are used, and more recently, techniques such as foliar supplementation to maintain nutrients during drought have also shown promise. However, specific combinations of these approaches are often untested for optimality. Here, we explore the effects of two maize planting practices (ridge sowing and mulching) to conserve water, in combination with foliar thiourea. Drought stress response of crop was assessed at two experimental sites (L‐I and L‐II), through split‐plot design (main plots: flat sowing + mulch, flat sowing, ridge sowing + mulch [RS + M] and ridge sowing; sub‐plots: unsprayed, water spray, 500 ppm thiourea and 1000 ppm thiourea). Plant performance was assessed via dry matter accumulation, grain growth rate, stomatal parameters, grain yield, stover yield and nitrogen uptake. Rainfall breaks induced three dry spells during the pre‐anthesis and grain‐filling period. RS + M showed maximum drought tolerance by enhancing rainwater and nutrient use (N uptake [88.1 and 115.1 kg ha−1]) and recorded significantly higher periodic dry matter accumulation (149.2 and 156.8 g) along with higher 1000‐grain weight (181.0 and 196.6 g), grain‐filling duration (36.3 and 34.9 days) and leaf health parameters over the flat‐sown treatments. Furthermore, foliar supplementation of thiourea at 1000 ppm caused improved leaf health, likely through activation of a source to sink response (transfer of energy and materials from leaves to other plant organs) that alleviated moisture stress. Ultimately, the combination of RS + M and 1000 ppm thiourea led to the highest grain yields (32.1 and 39.5 qha−1).
Integrative taxonomy reveals a new species of Characidium (Characiformes: Crenuchidae) shared by tributaries of upper Tapajós and Xingu river basins, Brazil
Authors: Zanata Angela Maria , Oliveira Claudio , Oliveira‐Silva Leonardo 
Published: September 2024

AbstractA new species of Characidium shared by adjacent tributaries of the upper portions of the Tapajós and Xingu river basins is described. Characidium varii, new species, can be distinguished from the congeners by having distinctly speckled pattern of colouration, including dark blotches on cheek and ventral surface of head, by having conspicuous dark marks on fins, along with a single row of dentary teeth, isthmus completely covered by scales, 14 circumpeduncular scales, and swimbladder reduced. Molecular data reinforce the validation of the new species. The distribution of C. varii supports the hypothesis of the existence of a faunistic mixing between Tapajós and Xingu river basins, corresponding to the region of the Serra do Cachimbo and surrounding areas, previously proposed in the literature.
Identifying marginal adaptation discrepancies of lithium disilicate crowns using seven different vertical X‐ray angulations
Authors: Carvalho Luiz , Becker Ryan , Oyoyo Udochukwu , Rice Dwight D. , Kattadiyil Mathew T. 
Published: September 2024

AbstractPurposeTo study the effect of different vertical angulations on the ability to radiographically assess vertical marginal discrepancies of lithium disilicate crowns.Materials and MethodsTwenty‐one lithium disilicate crowns were fabricated for three different prepared natural teeth: incisor, canine, and premolar. Vertical marginal discrepancies ranging from 0 to 300 µm were intentionally created. The seated crowns were radiographed using seven different vertical angulations, totaling 147 images. Thirty experienced evaluators scored each image for marginal discrepancy, and values were statistically analyzed.ResultsSignificant differences in the ability to accurately assess marginal discrepancies from radiographs were observed for the study factors of angulation, tooth type, and degree of marginal discrepancy (p < 0.001).ConclusionsThe radiographic interpretation of the marginal discrepancies of lithium disilicate crowns is significantly affected by the dimension of the marginal discrepancy. Specifically on premolar crowns, it is significantly affected by different vertical angulations of the X‐ray beam. When evaluating marginal discrepancy on lithium disilicate crowns radiographically, vertical beam angulation within ±10° to the cemento‐enamel junctionCEJ plane is recommended.
A single center experience on PI3K/AKT/MTOR signaling defects: Towards pathogenicity assessment for four novel defects
Authors: Bildik Hacer Neslihan , Esenboga Saliha , Halaclı Sevil Oskay , Karaatmaca Betül , Aytekin Elif Soyak , Nabiyeva Nadira , Akarsu Ayşegul , Ocak Melike , Erman Baran , Tan Cagman , Arikoglu Tugba , Yaz Ismail , Cicek Begum , Tezcan Ilhan , Cagdas Deniz 
Published: September 2024

AbstractBackgroundPhosphoinositide 3 kinases (PI3K) are lipid kinases expressed in lymphocytes/myeloid cells. PI3K/AKT/mTOR signaling defects present with recurrent infections, autoimmunity, lymphoproliferation, and agammaglobulinemia.ObjectiveTo characterize the PI3K/AKT/mTOR pathway defects and perform pathway analyses to assess novel variant pathogenicity.MethodsWe included 12 patients (heterozygous PIK3CD (n = 9) and PIK3R1 (n = 1) (activated PI3K delta syndrome (APDS) with gain‐of‐function mutations) and homozygous PIK3R1 variant (n = 2)), performed clinical/laboratory/genetic evaluation, and flow cytometric PI3K/AKT/mTOR pathway analyses.ResultsMedian age at onset of complaints was 17.5 months (3 months to 12 years) and at diagnosis was 15.7 years (2.5–37) in APDS. Median diagnostic delay was 12.9 years (1.6–27). Recurrent respiratory tract infections (90%), lymphoproliferation (70%), autoimmune/inflammatory findings (60%), and allergy (40%) were common in APDS. Recurrent viral infections were present in 4/10 and malignancy (non‐Hodgkin lymphoma and testicular yolk sac tumor) was present in 2/10 in APDS. Low CD4+ T cells(5/8) with increased CD4+ effector memory (8/8) and CD4+ TEMRA cells (6/8) were present in the given number of APDS patients. We diagnosed tubulointerstitial nephritis, Langerhans cell histiocytosis, and late‐onset congenital adrenal hyperplasia in APDS. Allergic findings, lymphoproliferation/malignancy, and high IgM were present in the APDS but not in PIK3R1 deficiency. Low IgM/IgG/CD19+ B cell counts were characteristic in patients with PIK3R1 homozygous loss‐of function mutations.ConclusionDifferential diagnosis with combined immunodeficiency and diseases of immune dysregulation make molecular genetic analysis crucial for diagnosing mTOR pathway defects. It is easy to differentiate APDS and homozygous PIK3R1 defects with specific laboratory features. Additionally, mTOR pathway functional analysis is a definitive diagnostic and pathogenicity assessment tool for novel APDS mutations.image
The Effects of the StartReact on Reaction Time, Rate of Force Development, and Muscle Activity in Biceps Brachii
Authors: Walker Simon , Tanel Meghan , Vekki Sakari , Kidgell Dawson J. , Baker Stuart N. 
Published: September 2024

ABSTRACTThe StartReact test, increasingly popular for assessing cortico‐reticular functioning, is a valid method to influence the firing of reticulospinal tract neurons noninvasively. However, there remains limited evidence on how different stimuli employed in the StartReact test impact motor output in humans. The present study tested elbow flexor responses of 33 adults (aged 26–48 years) to visual stimuli only (LED light), audio‐visual (80 dB) stimuli, and startle‐inducing audio‐visual (120 dB) stimuli sitting with the arm supinated in an electromechanical dynamometer. Surface electromyogram (EMG) recorded muscle activity from the right biceps brachii muscle. Participants were presented with 20 stimuli for each of the three conditions in pseudorandom order with interstimulus intervals of ~8 s. Reaction times were calculated from the stimulus trigger to the initial rise in the EMG signal above 7 × SD from baseline. Rate of torque development (RTD) and EMG signals were recorded throughout and analyzed over their initial 50 ms and 100 ms time‐windows. Reaction times were reduced from visual (169 ± 23) to audio‐visual (140 ± 23) and further reduced to startle‐inducing audio‐visual stimuli (108 ± 19, p < 0.001). While RTD and EMG were consistently greatest following startle‐inducing stimuli (p < 0.001), they were also enhanced following all audio‐visual stimuli over 100 ms (p < 0.05). It appears that startle‐inducing audio‐visual stimuli result in shorter reaction times, increased RTD, and enhanced muscle activity within the initial 50 ms, likely from subcortical upregulation. However, the 100 ms time‐window suggests cortical upregulation following all audio‐visual stimuli considering the longer transmission times.
Assessment of Urban Environmental Quality by Socioeconomic and Environmental Variables Using Open‐Source Datasets
Authors: Lingye Tan , Saleem Nayyer , Aslam Rana Waqar , Sajjad Asif , Naz Iram , Tariq Aqil , Alzahrani Hassan 
Published: September 2024

ABSTRACTIn this era of rapid development, environmental quality is an essential aspect of sustainable development. A healthy urban environment supports, regulates, and provides livable conditions. In urban areas, environmental quality is considerably affected by socioeconomic factors such as population expansion and economic development. For decision‐making, it is also significant for stakeholders and policymakers to understand the impact of urban expansion on environmental quality. While previous studies have examined urban environmental quality, they often focused on single cities or limited environmental parameters. This research addresses these limitations by conducting a comparative analysis of two major Asian cities with similar demographic features, utilizing a comprehensive set of socioeconomic and environmental variables. Our innovative approach combines open‐source datasets with advanced remote sensing techniques to provide a more holistic assessment of urban environmental quality over two decades. We analyzed urban environmental quality for last two decades with the selected urban environmental quality parameters: surface greenness, surface moisture, and land surface temperature. Lahore (Pakistan) and Wuhan (China) cities were selected for having approximately same demographic features. Correlation matrix has been used to assess the relationship between these environmental variables and social‐economic variables: urban expansion and carbon emission. Correlation coefficient indicated that urban expansion correlates negatively with surface greenness and surface moisture for both Lahore (−0.67 and −0.71) and Wuhan District (−0.5 and −0.75), respectively, while it had a positive relation with land surface temperature: 0.65 and 0.57 for Lahore and Wuhan District, respectively. These effects are more prominent within 10 km distance from the city center, where a substantial urban expansion is observed during the time window.
The experiences of patients with oesophageal cancer receiving chemoradiotherapy treatment: a qualitative study embedded in the SCOPE2 trial
Authors: Holland-Hart Daniella , Longo Mirella , Bridges Sarah , Nixon Lisette Sheena , Hawkins Maria , Crosby Tom , Nelson Annmarie 
Published: September 2024

ObjectivesThis qualitative study explored patients’ experiences and perceptions of the SCOPE2 trial. SCOPE2 examined radiotherapy dose escalation in patients with inoperable oesophageal cancer treated with definitive chemoradiotherapy (dCRT).SettingRecruitment at five clinical sites in England and Wales, UK.ParticipantsSCOPE2 trial participants were invited to take part in interviews from across five clinical sites. Participants self-selected to take part in up to three interviews across four different time points: baseline (before treatment) and at 2–3 months, 3–6 months or 6 months+ after baseline. There were five female and five male interview participants.InterventionsParticipants were randomised to standard dose dCRT prescribed carboplatin/paclitaxel or cisplatin/capecitabine, or an escalated dose dCRT prescribed carboplatin/paclitaxel or cisplatin/capecitabine.MethodsThis qualitative study used semistructured longitudinal interviews to explore the impact of treatment on patient outlook and quality of life and the impact of the COVID-19 pandemic. Interview data were thematically analysed.Results10 patients participated in 16 longitudinal interviews. Three participants were accompanied by companions. Participants experienced side-effects from radiotherapy and chemotherapy including nausea, throat pain, difficulties eating and regaining appetite, thrombosis and fatigue, although most of these symptoms gradually improved. Participants required more ongoing information and support regarding treatment side-effects and cancer status in order to improve their overall quality of life. Best practice examples involved key contacts providing practical advice and signposting support.ConclusionParticipants of the SCOPE2 trial reported short and longer-term side-effects from chemoradiotherapy, but these usually lessened over time. Participants attempted to be positive about their survival prospects by readjusting their expectations, priorities and lifestyles. Providing patients with ongoing opportunities to discuss detailed and timely information regarding treatment side-effects, aftercare and cancer status could improve the overall health and well-being of patients during oesophageal cancer trials and pathways.Trial registration numberNCT02741856; ISRCTN: 97125464.