bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma
Authors: Tang Ling , Zeng Jun , Geng Pengyu , Fang Chengnan , Wang Yang , Sun Mingju , Wang Changsong , Wang Jiao , Yin Peiyuan , Hu Chunxiu , Guo Lei , Yu Jane , Gao Peng , Li Enyou , Zhuang Zhengping , Xu Guowang , Liu Yang 
Published: October 2017

Abstract
Purpose: Metabolic reprogramming is frequently identified in hepatocellular carcinoma (HCC), which is the most common type of liver malignancy. The reprogrammed cellular metabolisms promote tumor cell survival, proliferation, angiogenesis, and metastasis. However, the mechanisms of this process remain unclear in HCC.
Experimental Design: The global nontargeted metabolic study in 69 paired hepatic carcinomas and adjacent tissue specimens was performed using capillary electrophoresis-time of flight mass spectrometry–based approach. Key findings were validated by targeted metabolomic approach. Biological studies were also performed to investigate the role of proline biosynthesis in HCC pathogenesis.
Results: Proline metabolism was markedly changed in HCC tumor tissue, characterized with accelerated consumption of proline and accumulation of hydroxyproline, which significantly correlated with α-fetoprotein levels and poor prognosis in HCC. In addition, we found that hydroxyproline promoted hypoxia- and HIF-dependent phenotype in HCC. Moreover, we demonstrated that hypoxia activated proline biosynthesis via upregulation of ALDH18A1, subsequently leading to accumulation of hydroxyproline via attenuated PRODH2 activity. More importantly, we showed that glutamine, proline, and hydroxyproline metabolic axis supported HCC cell survival through modulating HIF1α stability in response to hypoxia. Finally, inhibition of proline biosynthesis significantly enhanced cytotoxicity of sorafenib in vitro and in vivo.
Conclusions: Our results demonstrate that hypoxic microenvironment activates proline metabolism, resulting in accumulation of hydroxyproline that promotes HCC tumor progression and sorafenib resistance through modulating HIF1α. These findings provide the proof of concept for targeting proline metabolism as a potential therapeutic strategy for HCC. Clin Cancer Res; 24(2); 474–85. ©2017 AACR.
Hypermagnesuria in Humans Following Acute Intravenous Administration of Digoxin
Authors: Abu-Amer Nabil , Priel Eldar , Karlish Steven J.D. , Farfel Zvi , Mayan Haim 
Published: October 2017

<b><i>Background:</i></b> Hypomagnesemia is a known predisposing condition for the appearance of digitalis toxicity. The detection of a genetic form of Mg urinary wasting with hypomagnesemia being caused by a mutation in the γ subunit (FXYD2) of the Na,K-ATPase, the pharmacological target of Digoxin, prompted us to investigate whether Digoxin administration increases urinary Mg excretion. <b><i>Methods:</i></b> Two groups of subjects, with rapid atrial fibrillation, received intravenous Digoxin (<i>n</i> = 9) or verapamil (<i>n</i> = 8), for heart rate control. During the following 4 h, blood and urinary creatinine, sodium, potassium, calcium, and magnesium levels were determined, and fractional excretion (Fex) values for Na, K, Ca, and Mg were calculated. <b><i>Results:</i></b> In the Digoxin group, at 60 min Fex Mg rose from 3.07 ± 1.21 to 7.58 ± 2.51% (an increase of 269 ± 107% of baseline, <i>p</i> &#x3c; 0.001), and at 240 min to 6.05 ± 2.30% (204 ± 56% of baseline, <i>p</i> &#x3c; 0.01). No significant change was observed for Fex Na, Fex K, and Fex Ca. A striking correlation was found between individual values of Fex Mg and serum Digoxin concentration (<i>r</i> = 0.678, <i>p</i> &#x3c; 0.0001). No significant correlation was found between Fex Na or Fex K and serum Digoxin. A correlation of borderline significance was found between Fex Ca and serum Digoxin (<i>r</i> = 0.349, <i>p</i> = 0.073). <b><i>Conclusions:</i></b> The hypermagnesuric effect of acute Digoxin treatment is reminiscent of the effect of the missense mutation in FXYD2, which assumes that FXYD2 is a positive regulator of Na,K-ATPase in the distal convoluted tubule (DCT). The borderline calciuric effect of Digoxin may point to an additional site of action, more proximal to the DCT, that is, the thick ascending limb.
Significance of MRI/Transrectal Ultrasound Fusion Three-Dimensional Model-Guided, Targeted Biopsy Based on Transrectal Ultrasound-Guided Systematic Biopsy in Prostate Cancer Detection: A Systematic Review and Meta-Analysis
Authors: Tang Yongquan , Liu Zhihong , Tang Liangyou , Zhang Ruochen , Lu Yiping , Liang Jiayu , Zou Zijun , Zhou Chuan , Wang Yujie 
Published: October 2017

<b><i>Purpose:</i></b> To assess MRI/Transrectal Ultrasound (TRUS) fusion three-dimensional model-guided targeted biopsy (3D-Tb) versus TRUS-guided systematic biopsy (Sb) in detecting overall and high-Gleason-score (≥7) prostate cancer (PCa). <b><i>Methods:</i></b> Pubmed and Web of science were searched. Studies with men having a suspicious lesion on MRI were included, which were divided into initial biopsy, previous negative biopsy, and mixed groups in meta-analysis. <b><i>Results:</i></b> Totally 13 cohorts in 12 studies, with 3,225 men were included. In total population, 3D-Tb and Sb did not differ significantly in the PCa detection rate (43.1 vs. 42.6%, <i>p</i> = 0.36), but after excluding initial biopsy group, the superiority of 3D-Tb became significant (<i>p</i> = 0.01); 3D-Tb had a significantly higher detection rate of high-Gleason-score PCa compared to Sb (30.0 vs. 24.1%, <i>p</i> &#x3c; 0.05); 3D-Tb plus Sb significantly improved the PCa detection rate based on Sb alone (52.7 vs. 42.6%, <i>p</i> &#x3c; 0.05). <b><i>Conclusions:</i></b> In men with increased serum PSA and/or abnormal DRE and suspicious lesion on MRI but non-previous evidence of PCa, 3D-Tb plus Sb improves the PCa detection rate based on Sb alone. 3D-Tb alone has better performance in detecting high-Gleason-score PCa, and tends to have a higher PCa detection rate in population with previous negative biopsy compared to Sb.
Religious Entrepreneurship
Authors: Adi Suwarto 
Published: October 2017

Abstract
This paper explores the religious entrepreneurship of three Javanese pastors in Indonesia. It intends to illustrate the religious values obtained by pastors through self-reflection and faith experience that are enabling them to undertake social transformation. Religious entrepreneurship is a concept that locates the pastor as an agent of social transformation. Based on seven months of fieldwork using an ethical anthropological approach, this paper seeks to describe not simply gkj’s pastors’ experience of changing society, but also the faith struggle of the church and its community members. By applying the concept of religious entrepreneurship, this paper examines the aforementioned elements in order to display religious values as an underlying motivation for the Javanese pastors’ social movement in shaping humanistic and ethical social transformation in rural Java.
Buying and Selling Law Books in Qing Beijing
Authors: Zhang Ting 
Published: October 2017

AbstractBeijing was an emerging legal publishing center in late imperial China and at least 60 commercial editions of law books were published there in the Qing. Beijing commercial publishers established close connections with the central government, which enabled them to obtain internal legal and administrative information and to print it for profit. Thanks to their close connections with other printing centers in places like Jiangnan and Jiangxi, Beijing publishers had convenient access to fine editions of legal books in the national book market. In the early 19th century when Jiangnan editions rose to dominance, Beijing publishers adjusted their publishing strategies by republishing Jiangnan editions and reducing the number of their own editions. During the Taiping war, Beijing publishers took the opportunity to expand their business. In the late Qing, Beijing was a flourishing legal printing center, selling a variety of legal books at affordable prices to readers who wanted to learn the law.
Kiwisaldula waiho and K. hurunui, two new species of Saldidae (Hemiptera: Heteroptera) from the South Island of New Zealand, with redescriptions of K. butleri (White) and K. laelaps (White)
Authors: LARIVIÈRE MARIE-CLAUDE , LAROCHELLE ANDRÉ 
Published: October 2017

Kiwisaldula waiho new species and K. hurunui new species, are described from the South Island of New Zealand. Kiwisaldula butleri (White, 1878) and K. laelaps (White, 1878), two taxonomically little-known taxa, are redescribed. Morphological descriptions are provided together with illustrations emphasising the most important diagnostic features of external morphology and male genitalia. Information is given on synonymy, type specimens, material examined, geographic distribution and biology.
Mixing Nonlocality and Mixing Anisotropy in an Idealized Western Boundary Current Jet
Authors: Chen Ru , Waterman Stephanie 
Published: October 2017

AbstractMotivated by the key role of western boundary currents in shaping water mass distribution and gyre water exchanges, this study characterizes mixing in an idealized western boundary current jet using a barotropic quasigeostrophic model with numerical particles deployed. Both the nonlocality of mixing, depicted by nonlocality ellipses, and mixing anisotropy, depicted by mixing ellipses, are estimated. Mixing is more nonlocal within the jet compared to the jet flanks. In general, the size of nonlocality ellipses, a metric of the degree of mixing nonlocality, scales with the eddy velocity magnitude and the equilibration time for diffusivity. The tilt and eccentricity of the nonlocality ellipses, a characterization of the anisotropy of mixing nonlocality, agree with those of momentum flux ellipses in the regions where mixing nonlocality is small. Mixing ellipse characteristics are flow regime dependent. In regions dominated by wave radiation, the mixing ellipses align with the contours of the wave streamfunction and are very anisotropic. Inside the recirculations, however, the mixing ellipses are nearly isotropic. Mixing ellipses are zonally elongated in the jet upstream because of the suppression of cross-jet mixing by the jet and the anisotropy of eddy velocity, and they can have negative minor axis length in the jet downstream, indicating negative cross-jet eddy diffusivity, which is consistent with upgradient eddy fluxes there. Thus, despite significant spatial heterogeneity in mixing nonlocality and anisotropy, in this idealized system at least, spatial patterns in these diagnostics tend to be relatively large scale and tied to larger-scale dynamics. The implications of these results to eddy parameterization and jet dynamics are discussed.
Observations of Gravity Waves with High-Pass Filtering in the New Generation of Geostationary Imagers and Their Relation to Aircraft Turbulence
Authors: Wimmers Anthony , Griffin Sarah , Gerth Jordan , Bachmeier Scott , Lindstrom Scott 
Published: October 2017

Abstract
This paper introduces a method of image filtering for viewing gravity waves in satellite imagery, which is particularly timely to the advent of the next-generation Advanced Himawari Imager (AHI) and the Advanced Baseline Imager (ABI). Applying a “high pass” filter to the upper-troposphere water vapor channel reveals sub-Kelvin-degree variations in brightness temperature that depict an abundance of gravity wave activity at the AHI/ABI sensitivity. Three examples demonstrate that this high-pass product can be exploited in a forecasting setting to identify possible varieties of turbulence-prone gravity waves that either 1) move roughly orthogonally to the apparent background flow or 2) produce interference as separate wave packets pass through the same location.
“Seven Erroneous Theses about Latin America” and the Emergence of a New Mexican Anthropology
Authors: Rodríguez Domínguez Emanuel 
Published: October 2017

Mexican social anthropology was established as a practical tool for combining field studies with proposals for government action. From its inception it was closely related to the revolutionary project of national integration, but by the end of the 1950s academics had begun to question indigenista policy and its relationship with anthropological practice. Rodolfo Stavenhagen’s “Seven Erroneous Theses about Latin America” was one such critique. During the 1970s and 1980s it led to a debate that influenced many areas of anthropological study, nurturing a new kind of Mexican anthropology. La antropología social en México se funda como una antropología práctica, en la medida en que sus precursores sostienen la importancia de conjuntar los estudios de campo con propuestas de acción gubernamental. Desde sus inicios la antropología social mexicana se relacionó íntimamente con el proyecto de integración nacional revolucionario, pero a fines de la década de los cincuenta surgieron una serie de posturas críticas que comenzaban a cuestionar la política indigenista y su relación con la práctica antropológica. Las “Siete tesis equivocadas sobre América Latina” de Rodolfo Stavenhagen se enmarcan en dicho quiebre político de la antropología social mexicana. El debate que generó este trabajo en los setentas y los ochentas diversificó las temáticas de estudio entre los principales exponentes de este campo de estudio potenciando el surgimiento de una nueva antropología mexicana.
Prognostic comparison of goal-oriented hemoperfusion and routine hemoperfusion combined with continuous venovenous hemofiltration for paraquat poisoning
Authors: Zhao Xuming , Xiao Yan , Zhu Jianliang , Xu Zhiping , Liu Lijun , Zhang Jinsong 
Published: October 2017

Objective To investigate the impact of goal-oriented hemoperfusion (HP) with monitoring of the paraquat concentration on the prognosis of patients with acute paraquat poisoning. Methods This prospective observational study involved patients with acute paraquat poisoning admitted from March 2012 to September 2015. The patients received either goal-oriented or routine HP. All other treatments were the same between the two groups. The primary endpoint was 28-day mortality after poisoning. The secondary endpoints were the incidence of organ dysfunction within 7 days and 7-day mortality. Results Eighty-four patients were enrolled (49 in the control group and 35 in the goal-oriented group). The two groups were similar in terms of clinical characteristics. There was no significant difference in the incidence of organ dysfunction between the two groups within 1 week of admission. Mortality on day 7 was significantly lower in the goal-oriented than control group, but there was no difference on day 28. However, 28-day mortality was significantly lower in the goal-oriented group among patients with an oral dose of ≤50 ml. Conclusions HP with monitoring of the urine paraquat concentration as goal-oriented therapy can reduce the early mortality of paraquat poisoning.
Influences on headache trigger beliefs and perceptions
Authors: Turner Dana P , Houle Timothy T 
Published: October 2017

Background Previous headache trigger studies have primarily utilized checklists to measure beliefs about triggers. While this work has defined the diversity of beliefs across headache sufferers, the strength of association and the frequency at which these triggers are encountered remain unexplored. Objective To measure the strength of association, frequency of encounter, and influences on trigger beliefs and perceptions using a laboratory assessment task. Methods This cross-sectional observational study, part of the HACOGS project, included adult current migraine, tension-type, or cluster headache sufferers. Participants rated the chances they would experience a headache if they were to encounter a specific trigger and the number of days per month they experience that trigger for 33 common triggers. Results All 300 participants contributed data on all triggers, with little missing data (1.2%). All triggers exhibited a high degree of inter-individual variability on the strength of association and encounter perceptions. Many triggers were perceived to be encountered daily (e.g., caffeine, air conditioning), and a full range of perceptions were observed for each trigger. Stress (75% chance of headache), missing a meal (60%), and dehydration (60%) were the triggers with the greatest potency beliefs. Only 8–15% of these beliefs were related to individual differences and 26–27% to the triggers themselves. Conclusions Participants expressed diverse beliefs and perceptions about the strength of many common headache triggers. Variation in these beliefs was not associated with individual differences or the triggers themselves. This finding supports the importance of measuring more than just the presence-absence of trigger beliefs.
Factors affecting postoperative pain and delay in discharge from the post-anaesthesia care unit: A descriptive correlational study
Authors: Chan Jason Ju In , Thong Sze Ying , Tan Michelle Geoh Ean 
Published: October 2017

Background: Pain occurring in the post-anaesthesia care unit (PACU) is common, distressing to patients and remains a management challenge for staff. This study aims to identify the factors affecting pain severity and delay in discharge of patients from the PACU. Methods: Data from 590 consecutive postoperative patients in the PACU was collected over one month in 2012 at the Singapore General Hospital. Patient demographics, surgical, intraoperative anaesthetic and recovery data were collected. The primary outcome measured was postoperative pain score and secondary outcome was a delay in discharge. Univariate and multivariate logistic regression were performed to determine preoperative and intraoperative variables that may be associated with pain and delayed discharge. Results: The majority (67.6%) of patients reported no to mild pain while 32.3% reported moderate to severe pain; 65.4% of patients had delayed discharge and 28.3% of these were a result of uncontrolled pain. Factors associated with moderate to severe postoperative pain included younger age, same day admissions, duration of operation >2 h, abdominal, upper limb and spine surgeries and use of general anaesthesia. Factors associated with delay in discharge included higher body mass index, abdominal, spine and superficial surgeries, use of general anaesthesia, moderate to severe pain score and use of nurse controlled analgesia. Conclusions: This study identifies predictive factors for postoperative pain and delay in discharge from the PACU. Knowledge of these factors may help in better clinical judgment for postoperative pain management and can lead to quality improvement measures for patient management and work flow in the PACU.
Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma
Authors: Kataoka Keisuke , Iwanaga Masako , Yasunaga Jun-ichirou , Nagata Yasunobu , Kitanaka Akira , Kameda Takuro , Yoshimitsu Makoto , Shiraishi Yuichi , Sato-Otsubo Aiko , Sanada Masashi , Chiba Kenichi , Tanaka Hiroko , Ochi Yotaro , Aoki Kosuke , Suzuki Hiromichi , Shiozawa Yusuke , Yoshizato Tetsuichi , Sato Yusuke , Yoshida Kenichi , Nosaka Kisato , Hishizawa Masakatsu , Itonaga Hidehiro , Imaizumi Yoshitaka , Munakata Wataru , Shide Kotaro , Kubuki Yoko , Hidaka Tomonori , Nakamaki Tsuyoshi , Ishiyama Ken , Miyawaki Shuichi , Ishii Ryohei , Nureki Osamu , Tobinai Kensei , Miyazaki Yasushi , Takaori-Kondo Akifumi , Shibata Tatsuhiro , Miyano Satoru , Ishitsuka Kenji , Utsunomiya Atae , Shimoda Kazuya , Matsuoka Masao , Watanabe Toshiki , Ogawa Seishi 
Published: October 2017

Key Points
ATL subtypes are further classified into molecularly distinct subsets with different prognosis by genetic profiling. PD-L1 amplifications are a strong genetic predictor for worse outcome in both aggressive and indolent ATL.
HDAC8 regulates long-term hematopoietic stem-cell maintenance under stress by modulating p53 activity
Authors: Hua Wei-Kai , Qi Jing , Cai Qi , Carnahan Emily , Ayala Ramirez Maria , Li Ling , Marcucci Guido , Kuo Ya-Huei 
Published: October 2017

Key Points
HDAC8 plays a key role in maintaining long-term hematopoietic repopulation. HDAC8 modulates p53 activity to ensure LT-HSC cell survival under stress.
Immune tolerance induction by nonmyeloablative haploidentical HSCT combining T-cell depletion and posttransplant cyclophosphamide
Authors: Aversa Franco , Bachar-Lustig Esther , Or-Geva Noga , Prezioso Lucia , Bonomini Sabrina , Manfra Ilenia , Monti Alessandro , Schifano Chiara , Zlotnikov-Klionsky Yael , Martelli Massimo F. , Sammarelli Gabriella , Sassi Maria , Soli Maurizio , Giuliodori Silvia , Benecchi Magda , Giuliani Nicola , Lohr Frank , Pratissoli Silvia , Reisner Yair 
Published: October 2017

Key Points
This study lays the foundation for the use of nonmyeloablative GVHD-free haploidentical HSCT. This approach offers treatment of hematological diseases and a safe potential platform for cell therapy and organ transplantation.
Draft genome sequence of Marinobacterium rhizophilum CL-YJ9T (DSM 18822T), isolated from the rhizosphere of the coastal tidal-flat plant Suaeda japonica
Authors: Choi Dong Han , Jang Gwang II , Lapidus Alla , Copeland Alex , Reddy T. B. K. , Mukherjee Supratim , Huntemann Marcel , Varghese Neha , Ivanova Natalia , Pillay Manoj , Tindall Brian J. , Göker Markus , Woyke Tanja , Klenk Hans-Peter , Kyrpides Nikos C. , Cho Byung Cheol 
Published: October 2017

AbstractThe genus Marinobacterium belongs to the family Alteromonadaceae within the class Gammaproteobacteria and was reported in 1997. Currently the genus Marinobacterium contains 16 species. Marinobacterium rhizophilum CL-YJ9T was isolated from sediment associated with the roots of a plant growing in a tidal flat of Youngjong Island, Korea. The genome of the strain CL-YJ9T was sequenced through the Genomic Encyclopedia of Type Strains, Phase I: KMG project. Here we report the main features of the draft genome of the strain. The 5,364,574 bp long draft genome consists of 58 scaffolds with 4762 protein-coding and 91 RNA genes. Based on the genomic analyses, the strain seems to adapt to osmotic changes by intracellular production as well as extracellular uptake of compatible solutes, such as ectoine and betaine. In addition, the strain has a number of genes to defense against oxygen stresses such as reactive oxygen species and hypoxia.
Does Neurologic Level in Pediatric Patients with Myelodysplasia Affect Body Fat?
Authors: Maguire Kathleen J. , Gurbani Barkha N. , Caron Marie-Josee , Zemanovic Jason R. , Howat Linda , Otsuka Norman Y. 
Published: October 2017

Background: Historically, pediatric patients with myelodysplasia have been found to have a higher percentage of body fat than age-matched, healthy controls. This study examines the relationship between body fat percentage and age, sex, neurologic level, walking ability, and comorbidities in pediatric myelodysplasia patients. Methods: A total of 91 patients underwent a thorough history and physical to document body fat percentage, neurologic level, and walking ability; a chart-review determined comorbidities. Results: Females with myelodysplasia had significantly higher percent body fat than males (p = 0.02). Among females, body fat percentage increased with age (1.2% per year). Males who were community ambulators had lower body fat than those who were household ambulators or nonambulatory. In both sexes, those with mid/high neurologic levels had significantly higher body fat than those with low neurologic levels. There was no relationship between comorbidities and body fat. Conclusions: In patients with higher neurologic levels and impaired walking abilities, treatment aimed at controlling obesity should be integral to the care of myelodysplasia patients.