bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract We096: Gene therapy of MAOA fine-tunes nuclear cAMP nanodomain and improves cardiac hypertrophy in mice
Authors: Xiang Wenjing , Sun Xingsheng , Su Chunyu , Xiang Yang , Wang Ying 
Published: October 2024

Cardiac hypertrophy, a precursor to heart failure, represents a leading cause of global mortality and morbidity. Current therapeutic strategies focused on reducing the heart's workload, demonstrate limited efficacy. Nuclear-localized cAMP emerges as a promising therapeutic target, intervening in hypertrophic gene transcription and exhibiting overactivation in hypertrophic cardiomyocytes. Despite its potential, the spatiotemporal regulation and molecular targets of nuclear-localized cAMP (NLS-cAMP) remain elusive.
Employing super-resolution imaging, we identified a pool of β1 adrenergic receptors (β1AR) at the nuclear envelope that transduces NLS-cAMP-PKA signaling in cardiomyocytes. Utilizing a nuclear-localized FRET biosensor, our investigations revealed that the deletion or inhibition of monoamine oxidase A (MAOA) amplifies the norepinephrine-induced NLS-β1AR activation signal. Conversely, overexpressing MAOA prevents NLS-B1AR activation, underscoring the critical role of MAOA in regulating the NLS-cAMP nanodomain.
Single-cell transcriptome analysis unveiled a decline in MAOA expression in a mouse cardiac hypertrophy model. Cardiac-specific deletion of MAOA in mice led to simultaneous hypertrophy and eventual heart failure. Mechanistically, MAOA deletion increased PKA-dependent phosphorylation of HDAC1, H3K27 acetylation, and chromatin accessibility of hypertrophic genes, including Nppa and Nppb. To validate therapeutic potential, we intraventricularly injected adeno-associated virus (AAV) 9 vectors expressing mcherry or mcherry-MAOA under the control of the cTNT promoter into mice. Inducing cardiac hypertrophy through Angiotensin II infusion five weeks later, mice preinjected with AAV-MAOA exhibited attenuated cardiac hypertrophy and improved cardiac function.
Our findings suggest that MAOA gene therapy holds promise for treating hypertrophy by specifically targeting the NLS-cAMP nanodomain, opening new avenues for targeted interventions in cardiac hypertrophy and heart failure.
A Fast Algorithm for All-Pairs-Shortest-Paths Suitable for Neural Networks
Authors: Jing Zeyu , Meister Markus 
Published: October 2024

Abstract
Given a directed graph of nodes and edges connecting them, a common problem is to find the shortest path between any two nodes. Here we show that the shortest path distances can be found by a simple matrix inversion: if the edges are given by the adjacency matrix Aij, then with a suitably small value of γ, the shortest path distances are Dij=ceil(logγ[(I-γA)-1]ij).We derive several graph-theoretic bounds on the value of γ and explore its useful range with numerics on different graph types. Even when the distance function is not globally accurate across the entire graph, it still works locally to instruct pursuit of the shortest path. In this mode, it also extends to weighted graphs with positive edge weights. For a wide range of dense graphs, this distance function is computationally faster than the best available alternative. Finally, we show that this method leads naturally to a neural network solution of the all-pairs-shortest-path problem.
Optimizing Attention and Cognitive Control Costs Using Temporally Layered Architectures
Authors: Patel Devdhar , Sejnowski Terrence , Siegelmann Hava 
Published: October 2024

Abstract
The current reinforcement learning framework focuses exclusively on performance, often at the expense of efficiency. In contrast, biological control achieves remarkable performance while also optimizing computational energy expenditure and decision frequency. We propose a decision-bounded Markov decision process (DB-MDP) that constrains the number of decisions and computational energy available to agents in reinforcement learning environments. Our experiments demonstrate that existing reinforcement learning algorithms struggle within this framework, leading to either failure or suboptimal performance. To address this, we introduce a biologically inspired, temporally layered architecture (TLA), enabling agents to manage computational costs through two layers with distinct timescales and energy requirements. TLA achieves optimal performance in decision-bounded environments and in continuous control environments, matching state-of-the-art performance while using a fraction of the computing cost. Compared to current reinforcement learning algorithms that solely prioritize performance, our approach significantly lowers computational energy expenditure while maintaining performance. These findings establish a benchmark and pave the way for future research on energy and time-aware control.
Bounded Rational Decision Networks With Belief Propagation
Authors: Schmid Gerrit , Gottwald Sebastian , Braun Daniel A. 
Published: October 2024

Abstract
Complex information processing systems that are capable of a wide variety of tasks, such as the human brain, are composed of specialized units that collaborate and communicate with each other. An important property of such information processing networks is locality: there is no single global unit controlling the modules, but information is exchanged locally. Here, we consider a decision-theoretic approach to study networks of bounded rational decision makers that are allowed to specialize and communicate with each other. In contrast to previous work that has focused on feedforward communication between decision-making agents, we consider cyclical information processing paths allowing for back-and-forth communication. We adapt message-passing algorithms to suit this purpose, essentially allowing for local information flow between units and thus enabling circular dependency structures. We provide examples that show how repeated communication can increase performance given that each unit’s information processing capability is limited and that decision-making systems with too few or too many connections and feedback loops achieve suboptimal utility.
Relating Human Error–Based Learning to Modern Deep RL Algorithms
Authors: Garibbo Michele , Ludwig Casimir J. H. , Lepora Nathan F. , Aitchison Laurence 
Published: October 2024

Abstract
In human error–based learning, the size and direction of a scalar error (i.e., the “directed error”) are used to update future actions. Modern deep reinforcement learning (RL) methods perform a similar operation but in terms of scalar rewards. Despite this similarity, the relationship between action updates of deep RL and human error–based learning has yet to be investigated. Here, we systematically compare the three major families of deep RL algorithms to human error–based learning. We show that all three deep RL approaches are qualitatively different from human error–based learning, as assessed by a mirror-reversal perturbation experiment. To bridge this gap, we developed an alternative deep RL algorithm inspired by human error–based learning, model-based deterministic policy gradients (MB-DPG). We showed that MB-DPG captures human error–based learning under mirror-reversal and rotational perturbations and that MB-DPG learns faster than canonical model-free algorithms on complex arm-based reaching tasks, while being more robust to (forward) model misspecification than model-based RL.
Increasing nutritional value using alternative protein from sago worm in gluten-free biscuit products
Authors: Sanphom T. , Fuengkajornfung N. , Manokit R. , Singkeaw K. , Kamdaeng O. 
Published: October 2024

Abstract
This research aimed to study the nutritional value of sago worm (Rhynchophorus Ferrugineus) powder, evaluate quantity of protein supplementation derived from sago worm in gluten-free biscuit and determine the nutritional value of the gluten-free biscuit products supplemented with protein from sago worm. It was found that the nutritional value in sago worm powder consisting of carbohydrates (11.14%), protein (24.65%), fat (54.18 %), and ash (2.41%) based on total weight. Dietary fibre content was 6.61% and the total energy was 699.99 kilocalories/100 g. As regards physical and chemical properties, increase in inclusion of sago worm powder led to a decrease in moisture content and an increase in quantity of protein. Increasing the sago worm powder resulting to the colour of the biscuits became darker. The results showed that an increase in sago worm hardness and fracturability to decreased. Sensory evaluation using a 9-point hedonic scale showed that the gluten-free biscuit with 5% sago worm powder of the total weight had the highest score. In addition, the developed products contained moisture content, carbohydrate, fat, protein, dietary fibre and ash of 58.86, 32.56, 6.34, 6.61 and 1.02%. The energy value was found to 567.42 Kcal/100 g.
42. Japanese Society of Electronic Music (JSEM) Concert
Authors: Mizuno Mikako 
Published: October 2024

On December 9, 2022, the JSEM (Japanese Society of Electronic Music) held a concert celebrating Xenakis’s centennial in Shibuya Densyo Hall, Japan. The year 2022 was also monumental year for JSEM as it represented the Society’s 30th anniversary. This concert featured a lecture by Takehito Shimazu, the diffusion of the eight prize-winning pieces of UPISketch International Competition, and the world premieres of five new pieces composed by JSEM composers and dedicated to Xenakis:
1.	Kyohei Hayashi: Galactic Blood (fixed audio-visual)
2.	Masahiro Oda: Vertigo (fixed audio-visual)
3.	Osamu Kadowaki: mesure space X (fixed audio)
4.	Satoshi Fukushima: uncountable structures I (fixed audio)
5.	Mikako Mizuno: Rosehip Surface (fixed audio)
45. In Memoriam, Joel Chadabe
Authors: Kanach Sharon 
Published: October 2024

The inimitable Joel Chadabe…friend, colleague, proverbial big brother for so many. The one and only person I have ever known who never pronounced the words ‘no’ or ‘impossible’.
In this Tribute, we hear from some of the people most touched by you: Bill Blakeney, Mike Kupietz, Lori Freedman, Peter Beyls, Roger Reynolds—in either words or music—or both.
What better occasion to render homage than in the Meta-Xenakis celebration, as Xenakis too would have been right there, had he been able, in recognizing and giving thanks for everything you did to champion his music: from releasing the first CD of his electronic works on your EMF label, to all the concerts and events you organized over the years in North America.
When, at the Xenakis Project of the Americas in 2017, we toyed with the idea of creating an oral history around Xenakis in America, you enthusiastically volunteered to be our ‘guinea pig’ and do a pilot interview, with Olga Touloumi, Laura Cocks, and Anne Lanzilotti. Several significant excerpts from that hour-long interview are rendered public here for the first time, supporting the Chadabe motto: ‘Our mission is to create a gift of knowledge for future generations’.
Sustainable release artifact in PLGA microspheres for prolonged local aesthetics in postoperative pain management
Authors: Chen Chong , Zhao Yejun , Tang Kaijia , Ning Honglong , Yu Xiaohua , Zhu Yueliang , Shi Qingyu 
Published: October 2024

The challenge of effectively managing long-term pain after surgery remains a significant issue in clinical settings. Although local anesthetics are preferred for their effective pain relief and few side effects, their short-lasting effect does not fully meet the pain relief needs after surgery. Articaine, widely used for postoperative pain relief as a local anesthetic, is pharmacologically limited by its short half-life, which reduces the duration of its pain-relieving effects. To overcome this issue, this study presents a new approach using poly (lactic-co-glycolic acid) (PLGA) microspheres for controlled articaine release, aiming to extend its analgesic effect while reducing potential toxicity. The PLGA microspheres were shown to extend the release of articaine for at least 72 h in lab tests, displaying excellent biocompatibility and low toxicity. When used in a rodent model for postoperative pain, the microspheres provided significantly prolonged pain relief, effectively reducing pain for up to 3 days post-surgery, without causing inflammation or tissue damage for over 72 h after being administered. The extended release and high safety profile of these PLGA microspheres highlight their promise as a new method for delivering local anesthetics, opening up new possibilities for pain management in the future.
Impact of Shared Decision-Making on Family Satisfaction With Intensive Care Services: ‘Share With Care’ has a New Meaning in ICU
Authors: Bhatt Margiben Tusharbhai , Chaudhuri Souvik , Ravindranath Sunil , Atri Viha , Maddani Sagar Shanmukhappa , P Vishwas , Fernandes Roshan 
Published: October 2024

Background: Physician’s clinical inputs and informed bystander opinions are essential for successful intensive care unit (ICU) patient outcomes. There is insufficient data regarding the impact of shared decision-making on treatment outcomes and family satisfaction in Indian ICU settings. We aimed to determine the effect of shared decision-making factors on family satisfaction with ICU services. Patients and Methods: Family bystanders of 336 ICU patients with a stay >72 hours were conveniently surveyed across 13 months prospectively using Family Satisfaction in the Intensive Care Unit 24 Revised (FS-ICU 24R) questionnaire. We analyzed the responses to determine shared decision-making factors impacting family satisfaction. Results: Univariate analysis of ten variables of FS-ICU 24R questionnaire decision-making subscale revealed that consistency of information (OR 8.71, P < 0.001), honesty of information (OR 7.04, P < 0.001), and frequency of communication with doctors (OR 6.25, P < 0.001) were associated with highest odds of family involvement and satisfaction. Multivariable logistic regression showed that consistency of information (adjusted OR 3.85, P < 0.001) and frequent doctor communication (adjusted OR 2.22, P = 0.02) were independent predictors associated with family satisfaction. The number of decision-makers ( P = 0.463) or family’s prior ICU experience ( P = 0.430) was not associated with family satisfaction. Conclusion: A consistent and honest effort to cater to the family’s information needs and frequent physician-bystander interaction is essential for family’s satisfaction with ICU services. This even outweighs other decision-making factors such as number of decision-makers and their prior ICU experience. Incorporating shared decision-making in counseling should be a continuing practice. Trial registry name: Clinical Trials Registry – India. Registration number: CTRI/2022/09/045571.
Twenty-Seven-Year Institutional Experience With Surgery for Adults With Congenital Heart Disease
Authors: Hughes Aeleia F. , Herrmann Jeremy L. , Rodefeld Mark D. , Slaven James E. , Turrentine Mark W. , Brown John W. 
Published: October 2024

Background Given improved contemporary survival of adults with congenital heart disease (ACHD), we aimed to evaluate trends in ACHD surgery and outcomes at a single center over a 27-year period. Methods Surgical databases were retrospectively queried for patients >18 years old who underwent ACHD surgery between January 1, 1994, and December 31, 2020. A total of 2,195 included patients underwent 2,425 cardiac surgical procedures within the specified time frame. Patients were grouped by era: I, 1994-2000; 2, 2001-2010; and 3, 2011-2020. Trends in primary cardiac diagnosis and surgical management were evaluated. Results The median age increased across the eras. The most common primary cardiac diagnoses (n = 2,425) overall were left ventricular outflow tract anomalies (n = 2,019, 83%), atrial septal defect (n = 407, 17%), right ventricular outflow tract anomalies (n = 360, 15%), and ventricular septal defect (n = 110, 4.5%). The most commonly observed procedures overall were operations on the left ventricular outflow tract (n = 1,633, 67%), aorta (n = 675, 28%), coronary arteries (n = 449, 19%), right ventricular outflow tract (n = 323, 13%), and atrial septal defect (n = 264, 11%). Major complications occurred in 10% of cases, and 58 patients died within 30 days of their operation yielding an operative mortality of 2.4%. Conclusion To our knowledge, this is the largest single center report on surgery for adults with congenital heart disease. Surgery for ACHD has been performed at our center with relatively low morbidity and mortality over the last few decades.
Poster 266: Sagittal Tibial Tubercle-Trochlear Groove Distance Predicts Patellofemoral Chondral Lesion Size and Is Associated With Postoperative Complications
Authors: Bi Andrew , Triana Jairo , Li Zachary , Campbell Kirk , Alaia Michael , Strauss Eric , Jazrawi Laith , Gonzalez-Lomas Guillem 
Published: October 2024

Objectives: The purpose of this study was to assess the association between sagittal tibial tubercle-trochlear groove (sTT-TG) distance and patellofemoral chondral lesion size in patients undergoing cartilage restoration procedures. Methods: A retrospective review of patients who underwent an osteochondral allograft (OCA) transplantation or autologous chondrocyte implantation (ACI) was conducted. Patients were included if they had an articular cartilage lesion located in the patella, trochlea, or both (bipolar lesions). Lesion size of individual patella and trochlear lesions were measured intra-operatively at implantation. Total lesion area was calculated as a sum of all present chondral lesions in the patellofemoral joint. The preoperative sTT-TG distance was measured independently on magnetic resonance imaging (MRI) by 2 authors and an Interclass Correlation Coefficient (ICC) was calculated. Categorical and linear regression models accounting for demographic variables and sTT-TG distance were used to assess the relationship between sTT-TG and lesion size. Results: Eighty patients (85 knees) composed of 50 women (mean age: 31.5±10.4 years) were included. Forty-one patients underwent OCA transplantation and 44 underwent ACI. Intra-rater (ICC: 0.99, 0.98) and inter-rater reliability (ICC: 0.96) were excellent for sTT-TG measurements. A bivariate correlation analysis demonstrated that sTT-TG was significantly inversely related to MRI defect size (-0.45, p<0.01). Similarly, sTT-TG was inversely related to patellar lesion size and total lesion area, but not trochlear lesion size (Table 1). When controlling for demographics, a more negative sTT-TG remained an independent predictor of larger defects on MRI and patellar lesions: 9.3 mm2 and 9.8 mm2 lesion size increase on MRI (p<0.001) and intraoperatively (p=0.01), respectively, for every 1 mm decrease in sTT-TG. For every 1 mm increase in sTT-TG, the risk of all complications occurring decreased by 14.1% (ß=0.859, p=0.007). Conclusions: In this cohort of patients undergoing patellofemoral cartilage restoration, a more negative sTT-TG distance is a predictor of larger patellar lesions and increased risk for all complications.
Poster 252: Osteochondral Allograft Transplantation After Failed Autologous Chondrocyte Implantation of the Knee: A Matched Cohort Analysis
Authors: Quigley Ryan , Weissman Alexander C. , Yazdi Allen A. , Schick Samuel , Frazier Landon P. , Gilat Ron , Yanke Adam B. , Cole Brian J. 
Published: October 2024

Objectives: Osteochondral allograft transplantation (OCA) is a well-established procedure for the management of osteochondral lesions of the knee. OCA after failed prior cartilage restoration procedures has demonstrated similar improvements in patient-reported outcomes (PROs). Outcomes following OCA after failed autologous chondrocyte implantation (ACI) have been minimally reported in the current literature. The present study aims to compare the clinical outcomes, reoperation rates, and failure rates of OCA following failed ACI with those of a matched cohort of patients undergoing primary OCA. Methods: A retrospective matched cohort analysis was conducted on 22 patients who underwent OCA following failed ACI between January 2001 and January 2021, with a minimum 2-year clinical follow-up. Patients were included regardless of concomitant procedures. These patients were matched by age, sex, body mass index, defect location, and defect size to a control group of patients who underwent primary OCA without prior ACI with a similar 2-year clinical follow-up. PROs, defect characteristics, reoperations, and failure rates were analyzed individually and compared between the 2 groups. Results: Twenty-two patients (100% follow-up) were included in the study group with an average follow-up of 5.72 ± 4.2 years (range: 2.0-14.5). The average age was 31.2 ± 6.4 years. Sixteen patients were female (73%) and 6 were male (27%). Patients did not differ in the number of previous surgeries, preoperative baseline PROs, or types of concomitant procedures between the study group and the matched cohort. Both cohorts demonstrated statistically significant postoperative improvements for all PROs including Lysholm, International Knee Documentation Committee, and Knee Injury and Osteoarthritis Outcome Score subscales (p < 0.05). There was no statistical difference between both groups when comparing improvements in PROs, number of reoperations, and failure rates (p > 0.05). Ten patients (45%) in the study group required a reoperation. Four patients (18%) failed OCA following an ACI due to significant graft delamination and disease progression at an average 2.4 ± 2.1 years. Two patients required further revision OCA and 2 underwent significant chondral debridement. All 4 patients were clinically asymptomatic at a final follow-up of 5.9 years. Conclusions: OCA is an excellent treatment option for patients after prior failed ACI. OCA following ACI demonstrates favorable clinical outcomes, comparable reoperation rates, and an acceptable failure rate, similar to OCA performed without prior OCA.
Poster 277: Increased Kinesiophobia Leads to Lower Return to Sport Rate and Clinical Outcomes Following Osteochondral Allograft Transplantation of the Knee
Authors: Triana Jairo , DeClouette Brittany , Montgomery Samuel R. , Avila Amanda , Shankar Dhruv S. , Alaia Michael J. , Strauss Eric J. , Campbell Kirk A. 
Published: October 2024

Objectives: Previous studies suggest that psychological readiness influences patients’ ability to return to sport (RTS) after surgery. The purpose of this study is to describe the postoperative psychological state of patients following osteochondral allograft (OCA) transplantation in the knee and to determine whether patient-perceived kinesiophobia is associated with the rate of RTS. Methods: A retrospective review of the electronic medical record at a single institution was conducted for all patients that underwent OCA transplantation from January 2010 to January 2020. Patient-reported outcomes including the Visual Analog Scale (VAS), Knee Injury and Osteoarthritis Outcome Score (KOOS), and the Tampa Scale of Kinesiophobia-11 (TSK-11) were collected. Patients were surveyed regarding their postoperative RTS status. Results: A total of 38 patients (52.6% female) were included in our analysis. Overall, RTS rate was 63.2% (n=24), with 50% (n=12) of these patients returning at a lower level of play. When comparing patients that RTS to those that did not, patients that RTS had significantly superior KOOS pain (p=0.019) and KOOS QOL (p=0.011). Measures of kinesiophobia (TSK-11) were significantly higher among patients that did not RTS (p=0.014), while satisfaction (p=0.410) and pain intensity (p=0.327) were comparable between groups. Logistic regression models controlling for demographic factors, VAS pain scores, and lesion size showed that for every one-point increase in TSK-11 kinesiophobia score, patients were 1.33 times more likely to return to sport at a lower level (p=0.009). For every one-point increase in TSK-11 scores KOOS QOL decreased by 2.39 points (p<0.001). Conclusions: Fear of reinjury decreases the likelihood that patients will return to their pre-operative level of sport after OCA transplantation. Patients that do not RTS report significantly greater fear of reinjury and inferior clinical outcomes, despite similar levels of satisfaction and pain compared to those that RTS.