bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pancreatico‐jejunostomy decreases post‐operative pancreatic fistula incidence and severity after central pancreatectomy
Authors: Borel Frédéric , Ouaissi Mehdi , Merdrignac Aude , Venara Aurelien , De Franco Valéria , Sulpice Laurent , Hamy Antoine , Regenet Nicolas 
Published: August 2017

BackgroundsCentral pancreatectomy (CP) is an alternative to pancreaticoduodenectomy and distal pancreatectomy in benign tumours of pancreatic isthmus management. It is known for a high post‐operative pancreatic fistula (POPF) rate. The purpose of this study was to compare POPF incidence between pancreatico‐jejunostomy (PJ) and pancreatico‐gastrostomy (PG).MethodsFifty‐eight patients (mean age 53.9 ± 1.9 years) who underwent a CP in four French University Hospitals from 1988 to 2011 were analysed. The distal pancreatic remnant was either anastomosed to the stomach (44.8%, n = 25) or to a Roux‐en‐Y jejunal loop (55.2%, n = 35) with routine external drainage allowing a systematic search for POPF. POPF severity was classified according to the International Study Group on Pancreatic Fistula (ISGPF) and Clavien‐Dindo classifications.ResultsThe groups were similar on sex ratio, mean age, ASA score, pancreas texture, operative time and operative blood loss. Mean follow‐up was 36.2 ± 3.9 months. POPF were significantly more frequent after PG (76.9 versus 37.5%, P = 0.003). PG was associated with significantly higher grade of POPF both when graded with ISGPF classification (P = 0.012) and Clavien‐Dindo classification (P = 0.044). There was no significant difference in post‐operative bleeding (0.918) and delayed gastric emptying (0.877) between the two groups. Hospital length of stay was increased after PG (23.6 ± 3.5 days versus 16.5 ± 1.9 days, P = 0.071). There was no significant difference in incidence of long‐term exocrine (3.8 versus 19.2%, P = 0.134) and endocrine (7.7 versus 9.4%, P = 0.575) pancreatic insufficiencies.ConclusionPG was associated with a significantly higher POPF incidence and severity in CP. We recommend performing PJ especially in older patients to improve CP outcomes.
Single‐dose pharmacokinetics of co‐crystal of tramadol–celecoxib: Results of a four‐way randomized open‐label phase I clinical trial in healthy subjects
Authors: Videla Sebastián , Lahjou Mounia , Vaqué Anna , Sust Mariano , Encabo Mercedes , Soler Lluis , Sans Artur , Sicard Eric , Gascón Neus , Encina Gregorio , Plata‐Salamán Carlos 
Published: August 2017

AimsCo‐crystal of tramadol–celecoxib (CTC) is a novel co‐crystal molecule containing two active pharmaceutical ingredients under development by Esteve (E‐58425) and Mundipharma Research (MR308). This Phase I study compared single‐dose pharmacokinetics (PK) of CTC with those of the individual reference products [immediate‐release (IR) tramadol and celecoxib] alone and in open combination.MethodsHealthy adults aged 18–55 years were orally administered four treatments under fasted conditions (separated by 7‐day wash‐out period): 200 mg IR CTC (equivalent to 88 mg tramadol and 112 mg celecoxib; Treatment 1); 100 mg IR tramadol (Treatment 2); 100 mg celecoxib (Treatment 3); and 100 mg IR tramadol and 100 mg celecoxib (Treatment 4). Treatment sequence was assigned using computer‐generated randomization. PK parameters were calculated using noncompartmental analysis with parameters for CTC adjusted according to reference product dose (100 mg).ResultsThirty‐six subjects (28 male, mean age 36 years) participated. Tramadol PK parameters for Treatments‐1, –2 and –4, respectively, were 263, 346 and 349 ng ml–1 (mean maximum plasma concentration); 3039, 2979 and 3119 ng h ml–1 (mean cumulative area under the plasma concentration–time curve); and 2.7, 1.8 and 1.8 h (median time to maximum plasma concentration). For Treatments 1, 3 and 4, the respective celecoxib PK parameters were 313, 449 and 284 ng ml–1; 2183, 3093 and 2856 ng h ml–1; and 1.5, 2.3 and 3.0 h. No unexpected adverse events were reported.ConclusionPK parameters of each API in CTC were modified by co‐crystallization compared with marketed formulations of tramadol, celecoxib, and their open combination.
Olodaterol shows anti‐fibrotic efficacy in in vitro and in vivo models of pulmonary fibrosis
Authors: Herrmann Franziska Elena , Wollin Lutz , Wirth Johannes , Gantner Florian , Lämmle Bärbel , Wex Eva 
Published: August 2017

Background and PurposeIdiopathic pulmonary fibrosis (IPF) is a fatal respiratory disease characterized by excessive fibroblast activation ultimately leading to scarring of the lungs. Although, the activation of β2‐adrenoceptors (β2‐AR) has been shown to inhibit pro‐fibrotic events primarily in cell lines, the role of β2‐adrenoceptor agonists has not yet been fully characterized. The aim of our study was to explore the anti‐fibrotic activity of the long‐acting β2‐adrenoceptor agonist olodaterol in primary human lung fibroblasts (HLF) and in murine models of pulmonary fibrosis.Experimental ApproachWe assessed the activity of olodaterol to inhibit various pro‐fibrotic mechanisms, induced by different pro‐fibrotic mediators, in primary HLF from control donors and patients with IPF (IPF‐LF). The in vivo anti‐fibrotic activity of olodaterol, given once daily by inhalation in either a preventive or therapeutic treatment regimen, was explored in murine models of lung fibrosis induced by either bleomycin or the overexpression of TGF‐β1.Key ResultsIn both HLF and IPF‐LF, olodaterol attenuated TGF‐β‐induced expression of α‐smooth muscle actin, fibronectin and endothelin‐1 (ET‐1), FGF‐ and PDGF‐induced motility and proliferation and TGF‐β/ET‐1‐induced contraction. In vivo olodaterol significantly attenuated the bleomycin‐induced increase in lung weight, reduced bronchoalveolar lavage cell counts and inhibited release of pro‐fibrotic mediators (TGF‐ß, MMP‐9 and tissue inhibitor of metalloproteinase‐1). Forced vital capacity was increased only with the preventive treatment regimen. In the TGF‐β‐overexpressing model, olodaterol additionally reduced the Col3A1 mRNA expression.Conclusion and ImplicationsOlodaterol showed anti‐fibrotic properties in primary HLF from control and IPF patients and in murine models of lung fibrosis.
Knowledge, attitudes, and behaviours of healthcare professionals regarding child maltreatment in China
Authors: Li X. , Yue Q. , Wang S. , Wang H. , Jiang J. , Gong L. , Liu W. , Huang X. , Xu T. 
Published: August 2017

AbstractBackgroundA new, recently issued national law and regulation in China conferred the responsibility of healthcare professionals in child maltreatment intervention. However, few studies have reported on the recognition and reporting of child maltreatment by healthcare professionals in China. The aim of this study was to assess healthcare professionals' knowledge, attitudes, and self‐perceived behaviour in terms of identifying, assessing, and reporting child maltreatment cases in China.MethodsA cross‐sectional survey of 877 healthcare professionals from four provinces was conducted using a structured questionnaire.ResultsThe respondents demonstrated insufficient knowledge on identifying potential child maltreatment cases. Over 30% of them were less than confident in the medical examination, evaluation, and treatment of child maltreatment cases, especially with regard to cases involving sexual abuse. Only 3.19% of respondents had ever received training on child maltreatment intervention, and as a result, lack of knowledge with regard to dealing with child maltreatment cases, referral procedures, and regulations was indicated to be the main cause of underreporting.ConclusionsHealthcare professionals in China have insufficient knowledge, skills, and confidence when it comes to dealing with all aspects of child maltreatment. Although participants reported a positive attitude towards their role in detecting and reporting child maltreatment cases, there are obstacles that hinder them from doing so. Appropriate training courses should be developed to empower professionals with knowledge and skills, as well as increase their confidence in dealing with suspected child maltreatment cases.
Early experience affects learning performance and neophobia in a cooperatively breeding cichlid
Authors: Bannier Francis , Tebbich Sabine , Taborsky Barbara 
Published: August 2017

AbstractThe ability to respond flexibly to environmental challenges, for instance by learning or by responding appropriately to novel stimuli, may be crucial for survival and reproductive success. Experiences made during early ontogeny can shape the degree of behavioural flexibility maintained by individuals during later life. In natural habitats, animals are exposed to a multitude of social and non‐social ecological factors during early ontogeny, but their relative influences on future learning ability and behavioural flexibility are only poorly understood. In the cooperatively breeding cichlidNeolamprologus pulcher, we investigated whether early social and predator experiences shape the learning performance, flexibility, and response to novelty of adults. Fish were reared either with or without parents and helpers and with or without perceived predation risk in a full‐factorial experiment. We investigated the influence of these treatments on learning performance and flexibility in a spatial acquisition and reversal learning task. To test for response to novelty, we performed a neophobia test. We found that fish reared with predator experience, but without the presence of older group members outperformed fish with other rearing backgrounds in reversal learning and that individuals, which had been reared in a socially more complex environment together with older group members responded less neophobic toward a novel object than individuals reared among siblings only. Comparative evidence from fish and rats suggests that these developmental effects may be driven by the cues of safety perceived in the presence of guarding parents.
Territoriality mediates atypical size‐symmetric cannibalism in the Amblypygi Phrynus longipes
Authors: Chapin Kenneth J. , Reed‐Guy Sarah 
Published: August 2017

AbstractCannibalism can have important demographic and ecological effects on populations. Typically, cannibalism is size‐structured, where larger individuals eat smaller conspecifics. Initial cursory observations of the whip spider, Phrynus longipes, however, suggested that cannibalism might not be size‐structured in this species, perhaps because cannibalism is often a by‐product of territory contests. We staged paired interactions and recorded latency to escalate to physical aggression or cannibalize to understand the dynamics of cannibalism and resource contests. We employed a multimodel comparative approach to tease apart the contest characteristics that best predicted cannibalism during behavioral trials between P. longipes opponents. We found that, while armament size symmetry predicted escalation of contests, cannibalism was best predicted by body mass asymmetry. Further, cannibalism was most likely to occur among individuals similar in armament, but dissimilar in body mass. This suggests a discrepancy between phenotypes that may have evolved to communicate resource holding potential (e.g., armaments which benefit individuals if dishonest), and body mass as a cue of resource holding potential.
Associations between lobster phyllosoma and gelatinous zooplankton in relation to oceanographic properties in the northern Gulf of Mexico
Authors: Greer Adam T. , Briseño‐Avena Christian , Deary Alison L. , Cowen Robert K. , Hernandez Frank J. , Graham William M. 
Published: August 2017

AbstractLobster phyllosoma are known to associate with large cnidarian medusae; however, direct quantitative observations are difficult because gelatinous zooplankton are extremely fragile, and the phyllosoma easily detach from their host when sampled by plankton nets. We provide the first large scale quantitative information of the distribution of this association using an in situ imaging system, with synoptic measurements of water column properties. All phyllosoma were identified as slipper lobsters (Scyllarus chacei) and were associated with previously unreported “hosts” such as small hydromedusae, doliolids, and siphonophores in the northern Gulf of Mexico. Along the shelf, phyllosoma were more likely to be present at greater depths and higher salinities. Approximately 30% of the 347 lobster phyllosoma imaged were attached to at least one gelatinous organism, and salinity and depth were positively related to the probability of attachment on 30 October, but did not show a significant relationship for the other days of sampling. Many of the phyllosoma were larger than the gelatinous organisms to which they were attached, and some gelatinous zooplankton showed damage likely from feeding by the phyllosoma. In this coastal environment, gelatinous zooplankton tended to be more abundant in the same offshore region where phyllosoma occurred, so these gelatinous “hosts” may provide a steady food supply in the more oligotrophic waters on the outer shelf. Similar complex interactions among zooplankton may influence the life histories of other species, hindering our ability to forecast ecosystem level processes until the population level consequences of species interactions are fully understood.
A B‐Spline Framework for Smooth Derivative Computation in Well Test Analysis Using Diagnostic Plots
Authors: Tago Josué , Hernández‐Espriú Antonio 
Published: August 2017

AbstractIn the oil and gas industry, well test analysis using derivative plots, has been the core technique in examining reservoir and well behavior over the last three decades. Recently, diagnostics plots have gained recognition in the field of hydrogeology; however, this tool is still underused by groundwater professionals. The foremost drawback is that the derivative function must be computed from noisy field measurements, usually based on finite‐difference schemes, which complicates the analysis. We propose a B‐spline framework for smooth derivative computation, referred to as Constrained Quartic B‐Splines with Free Knots. The approach presents the following novelties in relation to methodological precedents: (1) the use of automatic equality derivative constraints, (2) a knot removal strategy and (3) the introduction of a Boolean shape parameter that defines the number of initial knots to choose. These can lead to evaluate both simple (manually recorded drawdown measurements) and complex (transducer measured records) datasets. Furthermore, we propose an additional shape preserving smoothing preprocess procedure, as a simple, fast and robust method to deal with extremely noisy signals. Our framework was tested in four pumping tests by comparing the spline derivative with regards to the Bourdet algorithm, and we found that the latter is rather noisy (even for large differentiation intervals) and the second derivative response is basically unreadable. In contrast, the spline first and second derivative led to smoother responses, which are more suitable for interpretation. We concluded that the proposed framework is a welcome contribution to evaluate reliable aquifer tests using derivative‐diagnostic plots.
Understanding the Geometry of Connected Fracture Flow with Multiperiod Oscillatory Hydraulic Tests
Authors: Sayler Claire , Cardiff Michael , Fort Michael D. 
Published: August 2017

AbstractAn understanding of the spatial and hydraulic properties of fast preferential flow pathways in the subsurface is necessary in applications ranging from contaminant fate and transport modeling to design of energy extraction systems. One method for the characterization of fracture properties over interwellbore scales is Multiperiod Oscillatory Hydraulic (MOH) testing, in which the aquifer response to oscillatory pressure stimulations is observed. MOH tests were conducted on isolated intervals of wells in siliciclastic and carbonate aquifers in southern Wisconsin. The goal was to characterize the spatial properties of discrete fractures over interwellbore scales. MOH tests were conducted on two discrete fractured intervals intersecting two boreholes at one field site, and a nest of three piezometers at another field site. Fracture diffusivity estimates were obtained using analytical solutions that relate diffusivity to observed phase lag and amplitude decay. In addition, MOH tests were used to investigate the spatial extent of flow using different conceptual models of fracture geometry. Results indicated that fracture geometry at both field sites can be approximated by permeable two‐dimensional fracture planes, oriented near‐horizontally at one site, and near‐vertically at the other. The technique used on MOH field data to characterize fracture geometry shows promise in revealing fracture network characteristics important to groundwater flow and transport.
Spatial distribution of the apatite fission‐track ages in the Toki granite, central Japan: Exhumation rate of a Cretaceous pluton emplaced in the East Asian continental margin
Authors: Yuguchi Takashi , Sueoka Shigeru , Iwano Hideki , Danhara Tohru , Ishibashi Masayuki , Sasao Eiji , Nishiyama Tadao 
Published: August 2017

AbstractThe Cretaceous Toki granitic pluton of the Tono district, central Japan was emplaced in the East Asian continental margin at about 70 Ma. The Toki granite has apatite fission‐track (AFT) ages ranging from 52.1 ±2.8 Ma to 37.1 ±3.6 Ma (number of measurements, n = 33); this indicates the three‐dimensional thermal evolution during the pluton's low‐temperature history (temperature in the AFT partial annealing zone: 60–120 °C). The majority of the Toki granite has a spatial distribution of older ages in the shallower parts and younger ages in the deeper parts, representing that the shallower regions arrived (were exhumed) at the AFT closure depth earlier than the deeper regions. Such a cooling pattern was predominantly constrained by the exhumation of the Toki granitic pluton and was related to the regional denudation of the Tono district. The age–elevation relationships (AERs) of the Toki granite indicate a fast exhumation rate of about 0.16 ±0.04 mm/year between 50 Ma and 40 Ma. The AFT inverse calculation using HeFTy program gives time‐temperature paths (t–T paths), suggesting that the pluton experienced continuous slow cooling without massive reheating since about 40 Ma until the present day. A combination of the AERs and AFT inverse calculations represents the following exhumation history of the Toki granite: (i) the fast exhumation at a rate of 0.16 ±0.04 mm/year between 50 Ma and 40 Ma; (ii) slow exhumation at less than 0.16 ±0.04 mm/year after 40 Ma; and (iii) exposure at the surface prior to 30–20 Ma. The Tono district, which contains the Toki granite, underwent slow denudation at a rate of less than 0.16 ±0.04 mm/year within the East Asian continental margin before the Japan Sea opening at 25–15 Ma and then within the Southwest Japan Arc after the Japan Sea opening, which is in good agreement with representative denudation rates obtained in low‐relief hill and plain fields.
Case of hydrocele testis caused by vaginalitis, a rare manifestation of immunoglobulin G4‐related disease
Authors: Tokura Yuumi , Kobayashi Minoru , Kusakabe Takashi , Kamai Takao 
Published: August 2017

AbstractWe report an extremely rare manifestation of immunoglobulin G4‐related disease, presented with hydrocele testis. A planned hydrocelectomy was converted to a high orchiectomy because of bloody fluid, suggestive of paratesticular malignancy. The histopathology showed vaginalitis, which was finally diagnosed as immunoglobulin G4‐related disease. To the best of our knowledge, this is the first report of immunoglobulin G4‐related disease representing hydrocele testis.
Getting the control across: Control transmission in information systems offshoring projects
Authors: Mähring Magnus , Wiener Martin , Remus Ulrich 
Published: August 2017

AbstractOffshoring of information systems (IS) projects has become a widespread global practice. While prior research suggests that controlling, and communicating with, offshore vendors represent key managerial challenges, the topic of how control is communicated, or transmitted, from client to vendor has been widely neglected. Our study focuses on control transmission in the critical relationship between client and offshore vendor managers, and its impact on the performance of IS offshoring projects. Drawing on a matched‐pair survey with 172 client and vendor managers from 86 projects, our results provide several new insights to the IS literature: First, we find that both behaviour and outcome control have the capacity to be transmitted consistently in lateral IS offshore project relationships. Second, our results show that consistent transmission translates into a performance effect only for outcome control. Third, we find that high‐performing offshore projects are characterized by both greater control transmission consistency and greater use of outcome control compared to low‐performing projects. In sum, our study extends theory on IS project control by highlighting that effective control of IS offshoring projects is not only about selecting proper controls but also about ensuring that, as a controller, you get the control across to the controllee.
Physicians' communication of risks from non‐steroidal anti‐inflammatory drugs and attitude towards providing adverse drug reaction information to patients
Authors: Phueanpinit Pacharaporn , Pongwecharak Juraporn , Sumanont Sermsak , Krska Janet , Jarernsiripornkul Narumol 
Published: August 2017

AbstractRationale, aims, and objectivesNonsteroidal anti‐inflammatory drugs (NSAIDs) are frequently prescribed for orthopaedic conditions, therefore this study aimed to explore orthopaedic physicians' perceptions of their role in NSAID‐risk communication, their attitudes towards the necessity of informing patients about adverse drug reactions (ADR), and factors associated with these.MethodsSelf‐administered questionnaires were mailed to all 206 orthopaedic physicians working at hospitals in Northeastern Thailand. Attitudes were assessed using 17 statements and total scores classed as poor, moderate and good attitude.ResultsSixty‐six questionnaires were returned (32.04%). The responses showed that 75% of physicians claimed to communicate NSAID ADR information, more frequently about gastrointestinal (GI) complications, than about renal and cardiovascular (CVS) complications. ADR management (36%) and monitoring (30%) were not frequently communicated. The time spent with patients was associated with provision of ADR and monitoring advice. Renal function was the risk factor of greatest concern for prescribing any NSAID, followed by history of GI complications, and allergy for non‐selective NSAIDs, and history of CVS diseases and age for selective COX‐2 NSAIDs. Most physicians (41) had moderate attitude towards providing information and 24 good attitude. Fewer physicians working in tertiary hospitals than general and community hospital physicians considered that time limitations prevented counseling and that patient information leaflets offered easily accessible information. Additionally, more physicians who did not inform patients about ADRs agreed that ADR communication can lead to anxiety and discontinuing treatment.ConclusionThe study indicates that, although orthopaedic physicians had positive attitudes towards providing ADR information to patients, improvement is needed in communicating NSAID risk information.