bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endodontic treatment of dens evaginatus by performing a splint guided access cavity
Authors: Mena‐Álvarez Jesús , Rico‐Romano Cristina , Lobo‐Galindo Ana Belén , Zubizarreta‐Macho Álvaro 
Published: July 2017

AbstractAimDens evaginatus (DE) is described as an unusual dental malformation. Tooth structure variations attached to this anatomical disturbance complicates the performance of a conservative access cavity for a conventional root canal treatment. Author's purpose is to describe the treatment of a type V DE by using splits as guides to perform access cavity.Clinical considerationsThis clinical case shows a root canal treatment of a type V DE diagnosed by using a cone beam computed tomography (CBCT). Access cavity was planned through an osseointegrated implant planning software and guided by a stereolithographied split. After endodontic treatment, tooth was sculpted for placing a veneer, processed by a chair‐side system in a single session.ConclusionsCBCT is an effective method for obtaining internal anatomical information of teeth with anatomical malformations. The osseointegrated implant planning software is an effective method for planning root canal treatment and designing stereolithograped splits (for performing minimally invasive access cavities).CLINICAL SIGNIFICANCEStereolithographed splints allow performing a guided and conservative access cavity of teeth affected by dental malformations whereas digital technology allows us to esthetically reconstruct a tooth in a single session.
Need to Recalibrate Research Outcomes in Alzheimer's Disease: Focus on Neuropsychiatric Symptoms
Authors: Canevelli Marco , Cesari Matteo , Lucchini Flaminia , Valletta Martina , Sabino Michele , Lacorte Eleonora , Vanacore Nicola , Bruno Giuseppe 
Published: July 2017

ObjectivesTo determine whether neuropsychiatric symptoms (NPSs) are adequately considered in clinical research on Alzheimer's disease (AD).DesignSystematic review.SettingRandomized controlled trials (RCTs) recruiting individuals with AD and published during the last 10 years in 16 major general medicine, neurology, psychiatry, and geriatric psychiatry journals and RCTs registered on clinicaltrials.gov and currently enrolling individuals with AD.ParticipantsIndividuals with AD.MeasurementsOutcome measures adopted by the included studies.ResultsOnly 21.4% of the included studies identified through the bibliographic searches had measures of NPSs as a primary outcome. Only 17.7% of the studies retrieved on clinicaltrials.gov made a specific effort to test the effect of pharmacological or nonpharmacological interventions on NPSs.ConclusionThese findings show how rarely previous and current research on AD has considered NPSs as primary research targets. Although these symptoms are widely recognized as the most‐stressful and ‐challenging manifestations of dementia, they are addressed much less often than other research targets.
Supportive care needs of patients with amyotrophic lateral sclerosis/motor neuron disease and their caregivers: A scoping review
Authors: Oh Juyeon , Kim Jung A 
Published: July 2017

Aims and objectivesTo identify the supportive care needs of amyotrophic lateral sclerosis/motor neuron disease patients and their caregivers, categorise and summarise them into a Supportive Care Needs Framework and identify gaps in literature.BackgroundLittle is known about the supportive care needs of amyotrophic lateral sclerosis/motor neuron disease patients and their caregivers, and this subject has not previously been systemically reviewed.DesignScoping review.MethodsWe conducted a scoping review from the MEDLINE, EMBASE, CINAHL and Cochrane databases for the period January 2000–July 2016, using the following inclusion criteria: (i) written in English only, (ii) published in peer‐reviewed journals, (iii) at least part of the research considered the supportive care needs perspective of amyotrophic lateral sclerosis/motor neuron disease patients or their caregivers and (iv) the population sample included patients of amyotrophic lateral sclerosis/motor neuron disease or their caregivers.ResultsThirty‐seven articles were included. Our review shows that amyotrophic lateral sclerosis/motor neuron disease patients and their caregivers’ supportive care needs were mentioned across all seven domains of the Supportive Care Needs Framework. Most common were practical needs (n = 24), followed by Informational needs (n = 19), Social needs (n = 18), Psychological needs (n = 16), Physical needs (n = 15), Emotional needs (n = 13) and Spiritual needs (n = 8).ConclusionFrom the perspectives of amyotrophic lateral sclerosis/motor neuron disease patients and their caregivers, there is a significant need for more practical, social, informational, psychological, physical, emotional and spiritual support.Relevance to clinical practiceThe Supportive Care Needs Framework has potential utility in the development of patient‐centred support services or healthcare policies and serves as an important base for further studies; especially, specific examples of each supportive care needs domain can guide in clinical settings when healthcare professionals provide multidisciplinary care to amyotrophic lateral sclerosis/motor neuron disease patients and individualised care.
Impact of immunosuppressive therapy on therapy‐neutralizing antibodies in transplanted patients with Fabry disease
Authors: Lenders M. , Oder D. , Nowak A. , Canaan‐Kühl S. , Arash‐Kaps L. , Drechsler C. , Schmitz B. , Nordbeck P. , Hennermann J. B. , Kampmann C. , Reuter S. , Brand S.‐M. , Wanner C. , Brand E. 
Published: July 2017

AbstractBackgroundInhibitory antibodies towards enzyme replacement therapy (ERT) are associated with disease progression and poor outcome in affected male patients with lysosomal disorders such as Fabry disease (FD). However, little is known about the impact of immunosuppressive therapy on ERT inhibition in these patients with FD.MethodsIn this retrospective study, we investigated the effect of long‐term immunosuppression on ERT inhibition in male patients with FD (n = 26) receiving immunosuppressive therapy due to kidney (n = 24) or heart (n = 2) transplantation.ResultsNo ERT‐naïve transplanted patient (n = 8) developed antibodies within follow‐up (80 ±72 months) after ERT initiation. Seven (26.9%) patients were tested ERT inhibition positive prior to transplantation. No de novo ERT inhibition was observed after transplantation (n = 18). In patients treated with high dosages of immunosuppressive medication such as prednisolone, tacrolimus and mycophenolate‐mofetil/mycophenolate acid, ERT inhibition decreased after transplantation (n = 12; P = 0.0160). Tapering of immunosuppression (especially prednisolone) seemed to re‐increase ERT inhibition (n = 4, median [range]: 16.6 [6.9; 36.9] %; P = 0.0972) over time. One ERT inhibition‐positive patient required interventions with steroid therapy and increased doses of tacrolimus, which also lowered ERT inhibition.ConclusionWe conclude that the immunosuppressive maintenance therapy after transplantations seems to be sufficient to prevent de novo ERT inhibition in ERT‐naïve patients. Intensified high dosages of immunosuppressive drugs are associated with decreased antibody titres and decreased ERT inhibition in affected patients, but did not result in long‐term protection. Future studies are needed to establish ERT inhibition‐specific immunosuppressive protocols with long‐term modulating properties to warrant an improved disease course in ERT inhibition‐positive males.
Plasma levels of hepatocyte growth factor and placental growth factor predict mortality in a general population: a prospective cohort study
Authors: Santalahti K. , Havulinna A. , Maksimow M. , Zeller T. , Blankenberg S. , Vehtari A. , Joensuu H. , Jalkanen S. , Salomaa V. , Salmi M. 
Published: July 2017

AbstractBackgroundCirculating levels of growth factors involved in leucocyte production and angiogenesis could be indicative of underlying aberrations of tissue homeostasis and therefore be utilized as predictors of risk for all‐cause cardiovascular disease (CVD) or cancer mortality.MethodsBaseline plasma levels of a range of growth factors were measured in two cohorts of the population‐based FINRISK study (1997 Discovery cohort, N = 8444, aged 25–74; 2002 Replication cohort, N = 2951, aged 51–74 years) using a multiplexed bead array methodology and ELISA. Participants were followed up by linking them to registry data.ResultsIn the Discovery cohort (653 deaths; 216 CVD‐related, 231 cancer‐related), fully adjusted Cox proportional hazard regression models showed that increased plasma hepatocyte growth factor (HGF) and placental growth factor (PlGF) were associated with higher risk of 10‐year mortality (HR, 1.29 [95% confidence interval (CI), 1.18–1.41] and HR, 1.23 [95% CI, 1.14–1.32], respectively). In the Replication cohort (259 deaths; 83 CVD‐related, 90 cancer‐related), baseline HGF levels also predicted all‐cause mortality (HR, 1.2 [95% CI, 1.08–1.32]; PlGF data not available). By including HGF levels in a CVD mortality model, 9% of all CVD deaths were correctly reclassified in the Discovery cohort (categorical net reclassification improvement [NRI] for events, P = 4.0 × 10−4). Moreover, adding HGF to all‐cause and CVD mortality models resulted in an overall clinical NRI of 0.10–0.18 in the Discovery cohort and meta‐analyses (P < 0.05 for all tests).ConclusionBlood levels of HGF and PlGF may serve as new biomarkers for predicting increased risk of death in the general population.
Does the presence of an occlusal indicator product affect the contact forces between full dentitions?
Authors: Mitchem J. A. , Katona T. R. , Moser E. A. S. 
Published: July 2017

SummaryStudies have explored occlusal marking interpretation, repeatability and accuracy. But, when an occlusion detection product is interposed between teeth, direct tooth–tooth occlusal contact relationships are replaced by tooth‐material‐tooth structures. Thus, the marks cannot reflect the original contacts. This has been shown for single tooth pair contacts. The purpose of this laboratory study was to similarly examine full dentitions. A dentiform was set into Class I centric occlusion with the mandible supported by a load cell. The maxillary arch was guided by precision slides. As the weighted (~52 N) upper assembly was lowered onto and raised off the mandibular arch, the loads on the mandible were measured. With and without (control) occlusal marking material, the steps were as follows: (cleaning – control 1 – material 1) … (cleaning – control 6 – material 6). The six materials were as follows: Accufilm I and II, Rudischhauser Thick and Thin, Hanel Articulating Silk and T‐Scan. Then, the six sets of (cleaning – control – material) measurements were repeated with the mandibular assembly shifted, in turn, by 0·1 mm in the Anterior, Posterior, Right and Left directions. The five (Centric and four 0·1 mm shifted) occlusal relationships produced grossly different tooth–tooth (control) load profiles. And, in general, these controls were affected, in different ways, by the marking products. Among the five conventional products, the Rudischhausers fared the worst and the electronic T‐Scan was an extreme outlier. Thus, in general, popular occlusal detection products alter the occlusal contact forces, and therefore, their markings cannot characterise the actual occlusion.
Effect of Functional Chewing Training on tongue thrust and drooling in children with cerebral palsy: a randomised controlled trial
Authors: Inal Ö. , Serel Arslan S. , Demir N. , Tunca Yilmaz Ö. , Karaduman A. A. 
Published: July 2017

SummaryTongue thrust, which is an oral reflex associated with sucking behaviour, may cause problems in swallowing, speech, oro‐facial development and also drooling. We aimed to examine the effect of Functional Chewing Training (FuCT) on tongue thrust and drooling in children with cerebral palsy. The study included 32 children with a mean age of 58·25 ± 9·58 months who had tongue thrust. Children were divided into two groups: the FuCT group and control group receiving classical oral motor exercises. Each group received training for 12 weeks. Oral motor assessment was performed. Chewing performance level was determined with the Karaduman Chewing Performance Scale. Tongue thrust severity was evaluated with the Tongue Thrust Rating Scale. The Drooling Severity and Frequency Scale was used to evaluate drooling severity and frequency. The evaluations were performed before and after treatment. Groups were well matched in age, gender and oral motor assessment. No significant difference was found between groups in terms of pre‐treatment chewing function, tongue thrust severity, drooling severity and frequency (P > 0·05). The FuCT group showed improvement in chewing performance (P = 0·001), tongue thrust severity (P = 0·046) and drooling severity (P = 0·002), but no improvement was found in terms of drooling frequency (P = 0·082) after treatment. There was no improvement in chewing performance, tongue thrust, drooling severity and frequency in the control group. A significant difference was found between groups in favour of FuCT group in tongue thrust severity (P = 0·043). This study showed that the FuCT is an effective approach on the severity of tongue thrust and drooling in children with CP.
The coralline genera Sporolithon and Heydrichia (Sporolithales, Rhodophyta) clarified by sequencing type material of their generitypes and other species
Authors: Richards Joseph L. , Sauvage Thomas , Schmidt William E. , Fredericq Suzanne , Hughey Jeffery R. , Gabrielson Paul W. 
Published: July 2017

Interspecific systematics in the red algal order Sporolithales remains problematic. To re‐evaluate its species, DNA analyses were performed on historical type material and recently collected specimens assigned to the two genera Sporolithon and Heydrichia. Partial rbcL sequences from the lectotype specimens of Sporolithon ptychoides (the generitype species) and Sporolithon molle, both from El Tor, Egypt, are exact matches to field‐collected topotype specimens. Sporolithon crassum and Sporolithon erythraeum also have the same type locality; material of the former appears to no longer exist, and we were unable to PCR amplify DNA from the latter. A new species, Sporolithon eltorensis, is described from the same type locality. We have not found any morpho‐anatomical characters that distinguish these three species. No sequenced specimens reported as S. ptychoides from other parts of the world represent this species, and likely reports of S. ptychoides and S. molle based on morpho‐anatomy are incorrect. A partial rbcL sequence from the holotype of Sporolithon dimotum indicates it is not a synonym of S. ptychoides, and data from the holotype of S. episporum confirm its specific recognition. DNA sequences from topotype material of Heydrichia woelkerlingii, the generitype species, and isotype material of Heydrichia cerasina confirm that these are distinct species; the taxon reported to be H. woelkerlingii from New Zealand is likely an undescribed species. Type specimens of all other Sporolithon and Heydrichia species need to be sequenced to confirm that they are distinct species; morpho‐anatomical studies have proved inadequate for this task.
Work for Passion or Money? Variations in Artists’ Labor Supply
Authors: Bille Trine , Løyland Knut , Holm Anders 
Published: July 2017

SummaryThis paper assesses the relative impact of work for money or work for passion on Norwegian artists by examining artists’ labor supply. Our contribution is twofold. The first is to test the work‐preference model and the second is to investigate the impact of arts grants on artists’ labor supply. The empirical specification draws two distinctions: between arts and non‐arts income and between labor and non‐labor income. Non‐labor income is divided into three different sources: (1) spouse's income, (2) income from financial assets and social benefits, and (3) arts grants and subsidies. Our contribution adds to the literature by estimating the significance of these various income sources on the time allocated to arts work, non‐arts work, and leisure. The results provide convincing evidence for the work‐preference model, and ad hoc evidence shows that art grants have a significant positive effect on the supply of arts hours. This finding supports arts policy and shows the impact of art grants on artists’ motivation to work on their arts. The causality of wages on supply is demonstrated by estimating the effects of wage shocks (grants) on arts labor supply using fixed‐effect and difference‐in‐difference methods.
Dissociated recovery between dementia and parkinsonism by transvenous embolization of recurrent dural arteriovenous fistula
Authors: Nakano Yumiko , Nomura Emi , Hiramatsu Masafumi , Takemoto Mami , Sato Kota , Hishikawa Nozomi , Yamashita Toru , Ohta Yasuyuki , Sugiu Kenji , Date Isao , Abe Koji 
Published: July 2017

AbstractDementia and parkinsonism are rarely observed in dural arteriovenous fistula. Here, we report a case of a 63‐year‐old man with recurrent dural arteriovenous fistula, who developed progressive dementia and parkinsonism as a result of a dural arteriovenous fistula at the torcular herophili. A sinus thrombosis induced the abnormal cortical venous reflux from the isolated straight sinus, resulting in the deep venous congestion of the thalamus and basal ganglia, which led to dementia and parkinsonism. However, the third endovascular embolization ameliorated memory disturbance and apathy with a slight improvement of parkinsonism. Although recoveries from dural arteriovenous fistula‐associated neurological deficits are variable depending on the severity, duration and, furthermore, selective vulnerability of the responsible ischemic lesions, early treatment should be essential for better recovery.
Diagnostic use of endoscopic full‐thickness wall resection (eFTR)—a novel minimally invasive technique for colonic tissue sampling in patients with severe gastrointestinal motility disorders
Authors: Valli P. V. , Pohl D. , Fried M. , Caduff R. , Bauerfeind P. 
Published: July 2017

AbstractBackgroundComplex gastrointestinal (GI) motility disorders such as chronic intestinal pseudo‐obstruction (CIPO) or Hirschsprung's disease (HD) are challenging to diagnose and treat appropriately. Thorough assessment of patient history, radiographic exams, endoscopy, and motility measurements aid in diagnostic workup, yet underlying histology is the cornerstone to enable a more distinct diagnosis of neuromuscular GI disorders. Traditionally, surgical procedures have been performed to obtain specimen suitable for accurate histologic analysis.MethodsWe performed endoscopic full‐thickness resection (eFTR) using a full‐thickness‐resection device (FTRD) under moderate propofol sedation in four patients with suspected severe neuromuscular gut disorders including CIPO.Key ResultsThe mean age of the four patients was 43 y (range 19‐56 y). Technical and histological success providing large colonic full‐thickness tissue samples of excellent quality was achieved in all four patients (success rate 100%). The mean procedure time was 12 min (range 5‐20 min). The mean diameter of the resected specimen was 21 mm (range 20‐22 mm). No adverse events connected to the procedure itself occurred. Histology ranged from aganglionosis such as Hirschsprung's disease (HD) to hypoganglionosis and eosinophilic leiomyositis combined with lymphocytic ganglionitis in a third patient. Histology was unspecific in one patient.Conclusion and InferencesEFTR allows safe and minimal invasive harvesting of ample full‐thickness tissue samples for accurate histological analysis in patients with suspicion of neuromuscular gut disorders.
Human eyes do not need monochromatic aberrations for dynamic accommodation
Authors: Bernal‐Molina Paula , Marín‐Franch Iván , Del Águila‐Carrasco Antonio J. , Esteve‐Taboada Jose J. , López‐Gil Norberto , Kruger Philip B. , Montés‐Micó Robert 
Published: July 2017

AbstractPurposeTo determine if human accommodation uses the eye's own monochromatic aberrations to track dynamic accommodative stimuli.MethodsWavefront aberrations were measured while subjects monocularly viewed a monochromatic Maltese cross moving sinusoidally around 2D of accommodative demand with 1D amplitude at 0.2 Hz. The amplitude and phase (delay) of the accommodation response were compared to the actual vergence of the stimulus to obtain gain and temporal phase, calculated from wavefront aberrations recorded over time during experimental trials. The tested conditions were as follows: Correction of all the subject's aberrations except defocus (C); Correction of all the subject's aberrations except defocus and habitual second‐order astigmatism (AS); Correction of all the subject's aberrations except defocus and odd higher‐order aberrations (HOAs); Correction of all the subject's aberrations except defocus and even HOAs (E); Natural aberrations of the subject's eye, i.e., the adaptive‐optics system only corrected the optical system's aberrations (N); Correction of all the subject's aberrations except defocus and fourth‐order spherical aberration (SA). The correction was performed at 20 Hz and each condition was repeated six times in randomised order.ResultsAverage gain (±2 standard errors of the mean) varied little across conditions; between 0.55 ± 0.06 (SA), and 0.62 ± 0.06 (AS). Average phase (±2 standard errors of the mean) also varied little; between 0.41 ± 0.02 s (E), and 0.47 ± 0.02 s (O). After Bonferroni correction, no statistically significant differences in gain or phase were found in the presence of specific monochromatic aberrations or in their absence.ConclusionsThese results show that the eye's monochromatic aberrations are not necessary for accommodation to track dynamic accommodative stimuli.
Soybean plant height QTL mapping and meta‐analysis for mining candidate genes
Authors: Yin Zhengong , Qi Huidong , Chen Qingshan , Zhang Zhanguo , Jiang Hongwei , Zhu Rongsheng , Hu Zhenbang , Wu Xiaoxia , Li Candong , Zhang Yong , Liu Chunyan , Hu Guohua , Xin Dawei , Qi Zhaoming 
Published: July 2017

AbstractPlant height is closely related to seed yield of soybean. The goal of this study was to identify important loci affecting soybean plant height using meta‐analysis based on a reference physical map. Plant height related to QTLs was mapped across eight years with a RIL population by WinQTLCart v2.5. 182 QTLs related to plant height of soybean from database and our research were collected, and each QTL was projected onto the soybean physical map by software BioMercator v2.1. The confidence interval of meta‐QTL ranged from 0.09 to 5.07 Mb, and the mean phenotypic variance ranged from 4.9% to 73.0%. Furthermore, 4,259 candidate genes were located in these consensus QTLs, and 40 of them were involved in the plant growth and stem elongation and annotated as plant hormone signal transduction (pathway ID ko04075) in KEGG pathway. These results would lay a foundation for fine mapping of QTLs/genes related to plant height and marker‐assisted selection for breeding in soybean.
Incorporating geographic distance into mate preference research: Necessities and luxuries, 2.0
Authors: JONASON PETER K. , NOLLAND MONIQUE , TYLER MICHAEL D. 
Published: July 2017

AbstractThis study (N = 370) examined mate preferences in men and women using the budget allocation paradigm across traits typically studied and the value placed on geographic proximity or propinquity. Importantly, traditionally studied preferences (i.e., physical attractiveness and social status) were seen as priorities, whereas the novel trait of distance was a luxury, suggesting that people were willing to travel to find a partner who satisfies their more important mate preferences. Men valued a short‐term mate who was close to them more than women did. Prior work on mate preferences was replicated in their context‐specific nature as per evolutionary models of mate choice.