bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of corrective feedback as a learning tool in dental education.
Authors: Pateel Deepak Gowda Sadashivappa , Gunjal Shilpa , Zain Rosnah Binti Mohd 
Published: October 2024

Abstract

Background
Formative assessment is believed to be an integral part of the learning process and plays an essential role in medical and dental education. Feedback is an integral part of formative assessment and, to some extent, supports and helps close the gaps between expected and actual performance, thus determining the formative assessment's success and purpose. The present study assesses the role of corrective feedback in dental education.
Methods
A Randomized, controlled, single-blinded, cross-over quasi-experimental study was conducted on all year three dental students of MAHSA University. The students were randomly divided into two groups, with 52 in each group. After the case-based formative assessment was conducted for all the students, the study group received corrective feedback, and the control group did self-study for the same period. A post-learning assessment was conducted for both groups, and the results were compared between the study and control groups. The data was analyzed using GraphPad Prism version 9.2.0 for Windows, GraphPad Software, San Diego, California, USA. The normality of data was checked using the D'Agostino & Pearson test with p > 0.05, indicating fulfilment of the normality assumption. The p < 0.05 was considered as statistical significance.
Results
The mean age for the study and control groups was approximately 22 years. Two-way repeated-measures ANOVA revealed no statistically significant difference between corrective feedback and self-study groups in the post-learning assessment (F = 0.3604, P = 0.5509).
Conclusions
The present preliminary study throws light on the role of corrective feedback after assessment as an educational learning tool in dental education. Although it has a lesser impact during the initial stages of the learning process, the study triggers further exploration of such education methods.
Pediatric Terrible Elbow Tetrad: A Case Report and Systematic Review
Authors: Galán-Olleros María , Garlito-Díaz Hugo , Martínez-Álvarez Sergio , Picazo-Belinchón Joaquín , Suárez-Betancor Marta , Mascaraque-Ortiz Rocío , Vara-Patudo Isabel , Martínez-Caballero Ignacio 
Published: October 2024

Abstract

A 6-year-old girl presented with a complex elbow injury, involving a posterior transolecranon fracture-dislocation and a radial neck fracture. Surgical intervention, performed through a posterior elbow approach, revealed an additional fracture of the coronoid process. Stabilization included a retrograde crossed K-wire for the radial neck fracture and a tension band construct (comprising K-wires and suture wire) for the olecranon fracture extending into the coronoid process. This combination of olecranon, radial neck, and coronoid fractures, coupled with a posterior elbow dislocation, constitutes a rare and intricate entity that may be regarded as a “terrible elbow tetrad”.
Acute Intestinal Obstruction Caused by Gastrointestinal Foreign Bodies in Children: A Comparison of Laparoscopic Treatment and Open Surgery
Authors: Wu Wei , Dong Min , Zhang Wanli , zheng Lulu , Sun Jun , Lv Zhibao 
Published: October 2024

Abstract

Objective
This study aims to explore the appropriate surgical treatment method for acute intestinal obstruction caused by gastrointestinal foreign bodies in children through a comparison of clinical characteristics in patients treated via laparoscopic and open surgery.
Methods
This study retrospectively analyzed 12 children with acute intestinal obstruction caused by gastrointestinal foreign bodies treated at Shanghai Children's Hospital and Huzhou Maternity and Child Care Hospital from June 2019 to June 2024. Basic information, treatment methods, and prognoses of the patients were collected. General data, operation time, postoperative fasting time, postoperative hospital stay, and intraoperative and postoperative complications were compared between the two groups. Categorical data were compared using Fisher’s exact test. Normally distributed continuous data were expressed as mean ± standard deviation and analyzed using an independent samples t-test; non-normally distributed data were expressed as M (P25, P75) and analyzed using the non-parametric Mann-Whitney U test.
Results
Six cases underwent laparoscopic transumbilical extended incision, successfully extracting the intestines and removing the foreign bodies without converting to open surgery. Compared to Six cases undergoing traditional open surgery during the same period, the postoperative fasting time and postoperative hospital stay in the laparoscopic group were 4 (5 ± 3.65) days and 5.5 (5 ± 7.5) days, respectively, while in the traditional open surgery group, they were 5 (4.25 ± 6) days and 6 (5 ± 8.6) days, respectively; the differences were statistically significant (P < 0.05). The laparoscopic group had significantly shorter operation time and faster postoperative recovery. The acceptance of the laparoscopic treatment by the families was significantly higher than that of the open surgery treatment.
Conclusion
The method of extracting obstructed intestines and removing foreign bodies via laparoscopic-assisted transumbilical extended incision has advantages over open surgery for treating acute intestinal obstruction caused by gastrointestinal foreign bodies, such as shortening hospital stay and operation time. However, for children with secondary gastrointestinal perforation caused by magnetic foreign bodies, open surgery, due to its broader exploration scope, is more advantageous for detecting occult perforations.
Transcriptomic Analysis of Identical Twins with ALD and Different Onset Ages
Authors: Chen Yinglian , Fu Chuhua , Zhang Yonghui , Zhang Yan , Cao Ying , Wang Xinggang , Zeng Zhiming , Liu Chen , Yin Changlin , Tan Liang 
Published: October 2024

Abstract

Background
Adrenoleukodystrophy (ALD) is a rare X-linked neurogenetic disease caused by mutations in the ABCD1 gene. Currently, the molecular mechanisms underlying the onset and severity of ALD still remain unclear. Therefore, the aim of this paper is to mine information on candidate genes associated with onset and severity of ALD by transcriptome sequencing of whole blood samples from monozygotic twin families with ALD disease.
Method
The identifying of differentially expressed genes (DEGs), set theory analysis, gene enrichment analysis, and classification statistics of expression trend had been executed to identify potential candidate genes inducing the onset and severity of ALD in patients. And, eight ALD patients, which constituted by two normal children, two ALD child twins, twins’ mother, twins’ adult uncle with ALD, twins’ grandmother, and a normal adult had been used.
Result
In the present, five distinct sets of differentially expressed genes (DEGs) were identified via using whole blood samples from a family of identical twins with different onset ages and ABCD1 exon 2 deletion. Then, 39 DEGs of A∩B∩C-D and A∩B-D as well as 425 DEGs of C∩E had been considered as relating genes with the onset and severity of ALD. Especially, C4BPA, TPBG, CEP112, CHST15, SMAD1, IL-26, and LRRC69 had shown more important than others about ALD onset. Meanwhile, KEGG and GO enrichment further suggested the role of Ca2+ homeostasis and plasma membrane for ALD onset and severity. Finally, expression pattern analysis further demonstrated the pivotal role of the selected DEG sets.
Conclusion
The information on candidate genes of this research had been considered as the crucial for preliminarily exploring the molecular mechanisms relating to the onset and severity of ALD, which offered novel insights and research directions for mitigating and treating the development of ALD.
Perspectives on Implementation of Point of Care Ultrasound in Prehospital Patient Care
Authors: Toole Austin , Dhillon Dev , Meeker Scott , Padilla Ricardo , Vaezazizi Reza , Pennington Troy , Archambeau Benjamin , Patterson Stephen , Dong Fanglong , Neeki Michael M. 
Published: October 2024

Abstract

Background:
Handheld point-of-care ultrasound (POCUS) devices offer potential benefits for enhancing patient care without causing delays in transporting patients to definitive care. This current study aims to assess the safety and effectiveness of POCUS used by paramedics in the prehospital setting alongside their standard assessment tools.
Methods:
This is a prospective longitudinal study from January 2022 and March of 2023. Eligible patients 18 years and older were categorized into two main groups: trauma or cardiac arrest. Trauma patients included those suspected of tension pneumothorax or intra-abdominal bleeding, while cardiac arrest patients were included regardless of etiology. Paramedics assessed and performed ultrasound exams based on their clinical judgment. Images were subsequently reviewed by an emergency physician trained in ultrasound interpretation, who evaluated the image quality and provided agreement or disagreement with the paramedics' interpretations.
Results:
In total, 92 patients were evaluated, and 41 patients with complete records were included for analysis. There are 24 cardiac arrest cases, which included 10 were noted to have cardiac activity on POCUS and the other 14 patients did not have cardiac activities on POCUS, and 17 were trauma. The agreement between paramedics’ interpretation and reviewing physicians’ interpretation ranged from 60% for those cardiac arrests with cardiac activities on POCUS, 78.6% for cardiac arrests without cardiac activities on POCUS, and 70.6% for trauma cases.
Conclusions:
These findings underscore the potential for paramedics, with appropriate training, to utilize ultrasound effectively in improving patient care for individuals suffering from traumatic injuries or in cardiac arrest.
Clinical trial number:
Not applicable. This is a prospective observational study. No intervention was applied to human subjects. This study was approved by the Institutional Review Board at Arrowhead Regional Medical Center (ARMC) with approval number 20-35.
Preoperative Serum Creatinine Levels as a Prognostic Indicator in Upper Urinary Tract Urothelial Carcinoma after Radical Nephroureterectomy: A Retrospective Clinical Study
Authors: Zhao Yu , Zhang Xin 
Published: October 2024

Abstract

Objective
This study aimed to elucidate the prognostic significance of preoperative serum creatinine (SCr) levels on oncologic outcomes in patients undergoing radical nephroureterectomy (RNU) for upper urinary tract urothelial carcinoma (UUT-UC).
Methods
We retrospectively analyzed clinical data from 227 patients treated for UUT-UC with RNU at Beijing Chaoyang Hospital, Capital Medical University between 2009 and 2020. Patients were stratified into groups based on optimal SCr thresholds identified via receiver operating characteristic (ROC) curve analysis. We compared baseline characteristics across these groups and assessed the impact of preoperative SCr on intravesical recurrence-free survival (IVRFS), extra-urinary recurrence-free survival (EURFS), recurrence-free survival (RFS), and overall survival (OS) using Kaplan-Meier survival plots and Cox proportional hazards regression models.
Results
Our cohort included 227 patients who fulfilled the study's inclusion and exclusion criteria. Pathologic T stage was identified as a predictor of IVRFS. Both pathologic T stage and preoperative SCr levels were significant predictors of EURFS and RFS. Additionally, age, pathologic T stage, neural invasion, and preoperative SCr were all significant prognostic factors for OS.
Conclusion
Elevated preoperative SCr levels are associated with poorer prognoses in patients with UUT-UC undergoing RNU, particularly impacting EURFS, RFS, and OS. Conversely, preoperative SCr levels did not correlate with IVR.
From Mammary Mystery to Parasitic Surprise: A Rare Case of Primary Breast Hydatid Cyst
Authors: Nezhad Nazanin Zeinali , Nezhad Hamid Zeinali , Shahpar Amirhossein , Shahrebabak Aazam Gholami , Shahrebabak Maryam Gholami 
Published: October 2024

Abstract

Primary breast hydatid cyst is an exceedingly rare manifestation of echinococcosis, with an incidence of less than 0.27% among all hydatid cyst cases. This report presents a unique case of a 51-year-old multiparous female who initially presented with a painless left breast mass. Initial imaging studies, including ultrasonography and mammography, revealed a 4.5 x 4 cm cyst classified as BI-RADS 3. The cyst was initially managed with fine-needle aspiration and conservative treatment. However, it recurred twice over a six-month period, necessitating surgical excision. Preoperative blood work revealed eosinophilia, a finding initially overlooked but later recognized as significant. Histopathological examination of the excised specimen confirmed the diagnosis of a hydatid cyst. Post-surgical management included albendazole therapy, regular imaging follow-ups, and patient education on hygiene practices to prevent reinfection. This case highlights the importance of considering parasitic etiologies in the differential diagnosis of breast masses, particularly in endemic regions. It also underscores the value of a multidisciplinary approach in managing such rare cases. The unexpected diagnosis of a primary breast hydatid cyst in this case serves as a reminder of the diverse presentations of echinococcosis and the need for heightened clinical suspicion in atypical breast lesions.
Association between age-based interpregnancy interval and adverse perinatal outcomes in the context of China's comprehensive two-child policy:A real-world based study
Authors: Xiu Siqin , Tang Li , Qin Chengjie , Tian Di , Chen Yuhong , Gu Lingling , Yang Liu , Sun Yuhao , Liu Xinghui , Lin Yonghong , Wang Yumei 
Published: October 2024

Abstract

Background
Since the implementation of China’s comprehensive two-child policy, the prevalence of long interpregnancy intervals (IPI) and advanced maternal age has increased. However, previous studies in China have mostly focused on the relationship between short IPIs and adverse perinatal outcomes, while neglecting maternal age as a potential confounder.
METHODS
We conducted a retrospective cohort study of 23,899 pregnant women who delivered between January 1, 2017 and December 31, 2019 at Chengdu Women's and Children's Central Hospital and West China Second Hospital of Sichuan University. IPIs were categorized as < 18 months, 18–23 months, 24–59 months, 60–119 months, and ≥ 120 months. Their relationships with clinical characteristics and pregnancy outcomes were analyzed using chi-square tests. Logistic regression modeling, incorporating restricted cubic spline (RCS), was used to assess association between IPI and adverse perinatal outcomes, including full-term low birthweight (LBW), preterm birth (PTB), small-for-gestational age (SGA) and adverse neonatal composite (very low birthweight, very preterm birth, severe neonatal asphyxia or death).
RESULTS
Women with longer IPIs (≥ 120 months) were more likely to be older (≥ 35 years) and had higher rates of gestational diabetes and hypertensive disorders of pregnancy (p < 0.05). Compared to an IPI of 24–59 months, the risk of PTB was significantly higher with an IPI of ≥ 120 months for women aged ≥ 35 years (aRR,1.39; 95% CI, 1.07–1.80) and 30–34 years (aRR 2.32; 95% CI, 1.72–3.13), but not for those aged ≤ 29 years (aRR 1.33; 95% CI, 0.28–6.43). The risk of SGA increased with an IPI of ≥ 120 months for women aged 30–34 years (aRR, 2.35; 95% CI, 1.13–4.89) and with an IPI of 60–119 months for women aged ≤ 29 years (aRR, 2.87; 95% CI, 1.47–5.60). Full-term LBW risk was elevated among women aged ≤ 29 years with an IPI of 60–119 months (aRR, 11.68; 95% CI, 1.41–97.19). However, there were no significant differences in the risk of adverse neonatal composite across different IPI groups with each age category (p > 0.05).
CONCLUSION
A long IPI increased the risk of SGA, full-term LBW and PTB, regardless of maternal age. Medical professionals should advise women an optimal IPI to mitigate these risks. With China’s shift from a “one-child” to a “three-child” policy, future research will focus on analyzing this new fertility pattern to refine IPI recommendations.
Proteomic analysis of plasma total exosomes and placenta-derived exosomes in patients with gestational diabetes mellitus in the first and second trimesters
Authors: Lin Jing , Zhao Danqing , Liang Yi , Liang Zhiyuan , Wang Mingxian , Tang Xiaoxiao , Zhuang Hongbin , Wang Hanghang , Yin Xiaoping , Huang Yuhan , Yin Li , Shen Liming 
Published: October 2024

Abstract

Gestational diabetes mellitus (GDM) is the first spontaneous hyperglycemia during pregnancy. Early diagnosis and intervention are important for the management of the disease. This study compared and analyzed the proteins of total plasma exosomes (T-EXO) and placental-derived exosomes (PLAP-EXO) in pregnant women who subsequently developed GDM (12–16 weeks), GDM patients (24–28 weeks) and their corresponding controls to investigate the pathogenesis and biomarkers of GDM associated with exosomes. The exosomal proteins were extracted and studied by proteomics approach, then bioinformatics analysis was applied to the differentially expressed proteins (DEPs) between the groups. At 12–16 and 24–28 weeks of gestation, 36 and 21 DEPs were identified in T-EXO, while 34 and 20 DEPs were identified in PLAP-EXO between GDM and controls, respectively. These proteins are mainly involved in complement pathways, immunity, inflammation, coagulation and other pathways, most of them have been previously reported as blood or exosomal proteins associated with GDM. The findings suggest that the development of GDM is a progressive process and that early changes promote the development of the disease. Maternal and placental factors play a key role in the pathogenesis of GDM. These proteins especially Hub proteins have the potential to become predictive and diagnostic biomarkers for GDM.
Am I attached? A patient-partnered approach to creating infographics about attachment to primary care in Ontario, Canada
Authors: MacNeil Maggie , Tagami Aya , Sheffield Peter , Ramsden Vivian R , Barker Joan , Boyle Jennifer , Cruickshank Clare , Frymire Eliot , H Glazier Richard , Hill Anita Gombos , Green Michael E , Huang Mary , Jurriaans Marijke , Leid Caron , McCallum Melissa , Precious Sarah , Stans JoAnn , Vizza Julie , Walz Murray , Wilkins Sue , Ganann Rebecca 
Published: October 2024

Abstract

Background: Having a primary care provider is associated with better care experiences and lower care costs. In 2021, INSPIRE-PHC released Primary Care Data Reports (PCDR) - publicly available summaries of administrative billing data about how populations in each of Ontario’s 60 health teams engage with primary care. Given the characterization of Canadian primary care systems as ‘in crisis’, publicly available data about primary care at the regional level presented a significant opportunity for knowledge mobilization. An understandable resource could ground the public conversation about primary care access in data. Recognizing the role that lived experience plays in ensuring the public understands research findings, a partnership between patient advisors, Ontario Health Team (OHT) representatives, researchers, and trainees was established to co-produce public-facing infographics of PCDR data.
Methods: Evidence-based guidelines for public health infographic creation and elements of transformative action research guided a six-meeting process to engage up to 14 patient advisors, three OHT staff and two primary care trainees. Patient advisors were affiliated with a provincial patient-oriented primary health care research group or a Hamilton-based OHT. Ninety-minute meetings were conducted virtually, and notes were shared with attendees to ensure they accurately reflected the conversation. Two consultations with OHT-affiliated primary care providers provided direction and ensured project outputs aligned with local priorities.
Results: Project partners shared feedback on draft infographics, audience identification, priority elements from PCDR to include in the infographics, and aesthetic features (e.g., headings, colour scheme, charts). Project partners felt the most important metrics to convey to the public were those that simultaneously reinforced the benefits of primary care on individual health outcomes and health system costs.
Conclusions: Patient engagement in research is becoming widespread, but co-developing knowledge products with patient and health system partners is less common. Our approach to engaging patients prevented both oversimplification and unnecessary complexity in a public-facing visual about attachment to primary care.
The effects of local delivery of laurus nobilis extract and adipose derived stem cells via electrospun gelatin scaffold on spinal cord injury inflammatory response and its regeneration
Authors: Zhang Chong , Xie Daotao , Guo Gang , Jalili saman 
Published: October 2024

Abstract

When subjected to injury, the spinal cord's inherent complexity poses significant challenges for effective healing. In this study, gelatin nanofibers loaded with laurus nobilis extract were developed to serve as a delivery system for adipose-derived stem cells (ASCs), aiming to explore its potential immunomodulatory effects in a rat model of spinal cord injury. Through a series of in vitro assessments including scanning electron microscopy imaging, cell viability, anti-inflammatory, cell adhesion, biodegradation, and hemocompatibility assays, the characteristics of the delivery system were thoroughly evaluated. The in vitro studies revealed both the biocompatibility of the scaffolds and their notable anti-inflammatory properties, laying the groundwork for further investigation. Subsequent in vivo experiments demonstrated that rats treated with laurus nobilis extract and ASCs loaded scaffolds exhibited heightened functional recovery and histological restoration at the 8-week mark post-injury. Notably, ELISA assay results revealed a significant reduction in tissue expression levels of key pro-inflammatory cytokines, including TNF-a, IL-1β, and IL-6, suggesting a pronounced immunomodulatory effect of the laurus nobilis extract-loaded scaffolds. These findings underscore the potential of this novel delivery system as a promising therapeutic approach for spinal cord injury, with implications for advancing clinical treatment strategies and improving patient outcomes. Further research is warranted to optimize and validate the efficacy of this approach in larger animal models and, ultimately, in human clinical trials.