bluuebunny/crossref_metadata_2025_split huggingface dataset:
MARRIED-cocaine score: validating a tool for detecting the risk of ED revisit in cocaine users
Authors: Galicia Miguel , Nogué Santiago , Miró Òscar 
Published: February 2016

ObjectiveAccording to a previous study, 17% of patients who attended an emergency department (ED) following cocaine use returned to the same ED over the next year for a problem related to drug use. This previous study proposed a scale (Multicenter Assessment of the Revisit Risk In the Emergency Department (MARRIED)-cocaine score) to quantify the risk of ED revisit. The aim of the present study was to validate this scale by analysing a new set of patients attending for cocaine use in nine Spanish EDs.MethodsWe performed a retrospective, multicentre, cohort study with consecutive patient inclusion, and without an intervention or control group. During 12 months (January–December 2010) we collected data from patients attending the ED after cocaine use. The MARRIED-cocaine score, ranging from 0 to 400 points, was calculated for each patient. The dependent variable was the identification of further visits associated with drug consumption to the same ED. Further analysis was performed to define risk categories.ResultsThe study included 933 patients, with a mean follow-up of 466 (SD 189) days, and 185 patients returned to the same ED for problems related to drug consumption. The cumulative probability of ED revisit was 4.2%, 8.3%, 16.8% and 21.2% at 1 month, 3 months, 12 months and 24 months, respectively. The area under the curve receiver operating characteristic for the MARRIED-cocaine scale was 0.69 (p<0.001). Four categories for ED revisit risk were defined: low risk (0–40 points, n=416), moderate risk (41–100 points, n=235), high risk (101–210 points, n=71) and very high risk (210–400 points, n=211), with HRs for ED revisit (with respect to the low-risk group) of 1.82 (95% CI 1.18 to 2.80, p=0.007), 2.65 (95% CI 1.50 to 4.66, p=0.001) and 5.06 (95% CI 3.49 to 7.35, p<0.001), respectively.ConclusionsThe MARRIED-cocaine score has a moderate discriminative capacity to predict revisit among patients who attend the ED for cocaine drug-related emergencies, and allows classification of patients according to the risk of ED revisit.
Prospective comparison of ultrasound and CXR for confirmation of central vascular catheter placement
Authors: Weekes Anthony J , Keller Stephen M , Efune Bradley , Ghali Sama , Runyon Michael 
Published: February 2016

ObjectiveTo prospectively compare ultrasound (US) versus CXR for confirmation of central vascular catheter (CVC) placement. Secondary objective was to determine the incidence of pneumothorax (PTX) and compare US with CXR completion times.MethodsInvestigators performed the US saline flush echo test, and evaluated each anterior hemithorax for pleural sliding with US after subclavian or internal jugular CVC placement.Measurements and main results151 total (135 in the emergency department, 16 in the intensive care unit) patients after CVC placement, mean age 62.1±15.6 years and 83 (55%) female patients. The rapid atrial swirl sign ( RASS) was ultrasound finding of an immediate appearance of turbulence entering the right atrium via superior vena cava after a rapid saline flush of the distal CVC port. RASS was considered ‘negative’ for CVC malposition. US identified all correct CVC placements. Four suboptimal CVC tip placements were detected by CXR. US identified three of these misplacements (McNemar exact p value >0.99). There were no cases of PTX or abnormal pleural sliding by either CXR or US. Median times for US and CXR completion were 1.1 (IQR 0.7) minutes and 20 (IQR: 30) minutes, respectively, median difference 23.8 (95% CI 19.6 to 29.3) minutes, p<0.0001.ConclusionsPTX and CVC tip malposition were rare after US-guided CVC placement. There was no significant difference between saline flush echo and CXR for the identification of catheter tip malposition. Benefits of US assessment for complications include reduced radiation exposure and time delays associated with CXR.
A qualitative study of the barriers to procedural sedation practices in paediatric emergency medicine in the UK and Ireland
Authors: McCoy Siobhán , Lyttle Mark D , Hartshorn Stuart , Larkin Philip , Brenner Maria , O'Sullivan Ronan 
Published: February 2016

IntroductionThere is extensive literature on paediatric procedural sedation (PPS) and its clinical applications in emergency departments (EDs). While numerous guidance and policy documents exist from international bodies, there remains a lack of uniformity and consistency of PPS practices within EDs. PPS is now gaining traction in the UK and Ireland and this study aimed to describe existing PPS practices and identify any challenges to training and provision of ED-based PPS.MethodsA qualitative approach was employed to capture data through a focus group interview. Nine consultants in emergency medicine (EM) participated, varying in years of experience, clinical settings (mixed adult and paediatric ED or paediatric only) and geographical location (UK and Ireland). The focus group was audio-recorded, transcribed verbatim and analysed using Attride-Stirling's framework for thematic network analysis.ResultsThe global theme ‘The Future of PPS in EM—A UK and Ireland Perspective’ emerged from the following three organising themes: (1) training and education of ED staff; (2) current realities of PPS in EDs and (3) PPS and the wider hospital community. The main findings were (1) there is variability in ED PPS practice throughout the UK and Ireland; (2) lack of formal PPS training for trainees is a barrier to its implementation as a standard treatment and (3) there is a lack of recognition of PPS at a College level as a specialised EM skill.ConclusionsEstablishment of PPS as a standard treatment option in the emergency setting will require implementation of robust training into general and paediatric EM training. This should be supported and enhanced through national and international collaboration in EM-led PPS research and audit.
Denosumab treated giant cell tumour of bone: a morphological, immunohistochemical and molecular analysis of a series
Authors: Girolami Ilaria , Mancini Irene , Simoni Antonella , Baldi Giacomo Giulio , Simi Lisa , Campanacci Domenico , Beltrami Giovanni , Scoccianti Guido , D'Arienzo Antonio , Capanna Rodolfo , Franchi Alessandro 
Published: February 2016

AimsDenosumab, a fully human monoclonal antibody directed against RANKL, has recently been introduced in the treatment strategy of giant cell tumour of bone (GCTB). Aim of this study was to investigate the phenotypical modifications induced by denosumab treatment in a series of 15 GCTB.MethodsThe tumours were characterised for histone 3.3 mutations, and studied immunohistochemically for the modifications of RANKL, RANK, SATB2 and RUNX2 expression, as well as of tumour proliferative activity and angiogenesis.ResultsNine of 11 tumours investigated presented a histone 3.3 mutation inH3F3A, and 2 of these for which the analysis was carried out in pretreatment and post-treatment specimens showed the same mutation in both. Denosumab induced the disappearance of osteoclast-like giant cells, leaving residual spindle neoplastic cells arranged in a storiform pattern, with deposition of trabecular collagen matrix and osteoid, which tended to maturation in the peripheral portions of the lesion. RANK and RANKL expression was variable, with no significant variation after treatment. Moreover, we did not observe any significant modification of the expression of the osteoblastic markers SATB2 and RUNX2. Denosumab treatment determined a significant reduction of the proliferative index and of tumour angiogenesis (p=0.001, Wilcoxon rank-sum test).ConclusionsThese results indicate that denosumab induces a partial maturation towards the osteoblastic phenotype of the neoplastic cells of GCTB, with production of fibrous and osteoid matrix, but with minor immunophenotypical changes. Finally, we first report an antiangiogenic activity of denosumab in GCTB, possibly mediated by a RANKL-dependent pathway.
Correlation between tobacco control policies, consumption of rolled tobacco and e-cigarettes, and intention to quit conventional tobacco, in Europe
Authors: Lidón-Moyano Cristina , Martín-Sánchez Juan Carlos , Saliba Patrick , Graffelman Jan , Martínez-Sánchez Jose M 
Published: February 2016

ObjectiveTo analyse the correlation between the implementation of tobacco control policies and tobacco consumption, particularly rolling tobacco, electronic cigarettes (e-cigarettes) users and the intent to quit smoking in 27 countries of the European Union.DesignEcological study with the country as the unit of analysis.Data sourcesWe used the data from tobacco control activities, measured by the Tobacco Control Scale (TCS), in 27 European countries, in 2010, and the prevalence of tobacco consumption data from the Eurobarometer of 2012.AnalysisSpearman correlation coefficients (rsp) and their 95% CIs.ResultsThere was a negative correlation between TCS and prevalence of smoking (rsp=−0.41; 95% CI −0.67 to −0.07). We also found a negative correlation (rsp=−0.31) between TCS and the prevalence of ever e-cigarette users, but it was not statistically significant. Among former cigarette smokers, there was a positive and statistically significant correlation between TCS and the consumption of hand-rolled tobacco (rsp=0.46; 95% CI 0.06 to 0.70). We observed a similar correlation between TCS and other tobacco products (cigars and pipe) among former cigarette smokers. There was a significant positive correlation between TCS and intent to quit smoking in the past 12 months (rsp=0.66; 95% CI 0.36 to 0.87).ConclusionsThe level of smoke-free legislation among European countries is correlated with a decrease in the prevalence of smoking of conventional cigarettes and an increase in the intent to quit smoking within the past 12 months. However, the consumption of other tobacco products, particularly hand-rolled tobacco, is positively correlated with TCS among former cigarette smokers. Therefore, tobacco control policies should also consider other tobacco products, such as rolling tobacco, cigars and pipes.
On-Line Handy Handwriting Chinese Characters Input for Non-Chinese Speakers Based on Wavelet Neural Network
Authors: Huang Tongcheng , Zhang Siyang , Duan Xu , Liang Ronglong 
Published: February 2016

Non-Chinese speakers hold increasing opportunities and need to process Chinese information and communicate in Chinese. This paper, with the purpose of facilitating the handwriting input of Chinese characters for non-Chinese speakers, is directed towards the development of the handwriting rules and vocabulary for Latin-style anti-cursive characters and the ways of their selection and classification. This aims to build a practical platform by utilizing three characteristics of wavelet neural network — automatically ascertaining the number of hidden layer unit, converging rapidly and never running into the partial minimum of networks — for a simple Latin-style online handwriting input and processing, meanwhile, taking the customary handwriting habits of non-Chinese speakers. The paper, based on profound information of cursive characters, deciphered the genetic code of ancient cursive symbols and made clear the rules for characters changing into its cursive style. As a result, it breaks the bottleneck, which enables non-Chinese speakers to easily input information through handwriting Chinese characters.
Recognition of PSL(2,p) ×PSL(2,p) by its complex group algebra
Authors: Khosravi Behrooz , Momen Zahra , Khosravi Behnam , Khosravi Bahman 
Published: February 2016

In [H. P. Tong-Viet, Simple classical groups of Lie type are determined by their character degrees, J. Algebra 357 (2012) 61–68] the following question arose: Question. Which groups can be uniquely determined by the structure of their complex group algebras? It is proved that every quasisimple group except covers of the alternating groups is uniquely determined up to isomorphism by the structure of [Formula: see text], the complex group algebra of [Formula: see text]. One of the next natural groups to be considered are the characteristically simple groups. In this paper, as the first step in this investigation we prove that if [Formula: see text] is an odd prime number, then [Formula: see text] is uniquely determined by the structure of its complex group algebra.
The First-in-class Anti-EGFR Antibody Mixture Sym004 Overcomes Cetuximab Resistance Mediated by EGFR Extracellular Domain Mutations in Colorectal Cancer
Authors: Sánchez-Martín Francisco J. , Bellosillo Beatriz , Gelabert-Baldrich Mariona , Dalmases Alba , Cañadas Israel , Vidal Joana , Martinez Alejandro , Argilés Guillem , Siravegna Giulia , Arena Sabrina , Koefoed Klaus , Visa Laura , Arpí Oriol , Horak Ivan David , Iglesias Mar , Stroh Christopher , Kragh Michael , Rovira Ana , Albanell Joan , Tabernero Josep , Bardelli Alberto , Montagut Clara 
Published: February 2016

Abstract
Purpose: Approved anti-EGFR antibodies cetuximab and panitumumab provide significant clinical benefit in patients with metastatic colorectal cancer (MCRC). However, patients ultimately develop disease progression, often driven by acquisition of mutations in the extracellular domain (ECD) of EGFR. Sym004 is a novel 1:1 mixture of two nonoverlapping anti-EGFR mAbs that recently showed promising clinical activity in a phase I trial in MCRC. Our aim was to determine the efficacy of Sym004 to circumvent cetuximab resistance driven by EGFR ECD mutations.
Experimental Design: Functional studies were performed to assess drug–receptor binding as well as ligand-dependent activation of individual EGFR mutants in the presence of cetuximab, panitumumab, and Sym004. Cell viability and molecular effects of the drugs were assayed in cetuximab-resistant cell lines and in tumor xenograft models. Efficacy of Sym004 was evaluated in patients progressing to cetuximab that harbored EGFR mutation in the post-cetuximab tumor sample.
Results: Contrary to cetuximab and panitumumab, Sym004 effectively bound and abrogated ligand-induced phosphorylation of all individual EGFR mutants. Cells resistant to cetuximab harboring mutations in EGFR maintained sensitivity to Sym004, which was consistent with an effective suppression of EGFR downstream signaling, translating into profound and sustained tumor regression in the xenograft model. As proof-of-principle, a patient with a tumor harboring an EGFR mutation (G465R) following cetuximab therapy benefited from Sym004 therapy.
Conclusions: Sym004 is an active drug in MCRC resistant to cetuximab/panitumumab mediated by EGFR mutations. EGFR mutations are potential biomarkers of response to Sym004 to be evaluated in ongoing large clinical trials. Clin Cancer Res; 22(13); 3260–7. ©2016 AACR.
Myeloid Differentiation Factor 88 Signaling in Bone Marrow–Derived Cells Promotes Gastric Tumorigenesis by Generation of Inflammatory Microenvironment
Authors: Maeda Yusuke , Echizen Kanae , Oshima Hiroko , Yu Liang , Sakulsak Natthiya , Hirose Osamu , Yamada Yoichi , Taniguchi Tadatsugu , Jenkins Brendan J. , Saya Hideyuki , Oshima Masanobu 
Published: February 2016

Abstract
It has been established that COX-2 and downstream signaling by prostaglandin E2 (PGE2) play a key role in tumorigenesis through generation of inflammatory microenvironment. Toll-like receptor (TLR) signaling through myeloid differentiation factor 88 (MyD88) also regulates inflammatory responses in tumors. However, the relationship between these distinct pathways in tumorigenesis is not yet fully understood. We herein investigated the role of MyD88 in gastric tumorigenesis using Gan mice, which develop inflammation-associated gastric tumors due to the simultaneous activation of the COX-2/PGE2 pathway and Wnt signaling. Notably, the disruption of Myd88 in Gan mice resulted in the significant suppression of gastric tumorigenesis with the inhibition of inflammatory responses, even though COX-2/PGE2 pathway is constitutively activated. Moreover, Myd88 disruption in bone marrow–derived cells (BMDCs) in Gan mice also suppressed inflammation and tumorigenesis, indicating that MyD88 signaling in BMDCs regulates the inflammatory microenvironment. We also found that expression of Tlr2 and its coreceptor Cd14 was induced in tumor epithelial cells in Gan mice, which was suppressed by the disruption of Myd88. It has already been shown that TLR2/CD14 signaling is important for stemness of intestinal epithelial cells. These results indicate that MyD88 in BMDCs, together with COX-2/PGE2 pathway, plays an essential role in the generation of the inflammatory microenvironment, which may promote tumorigenesis through induction of TLR2/CD14 pathway in tumor epithelial cells. These results suggest that inhibition of TLR/MyD88 signaling together with COX-2/PGE2 pathway will be an effective preventive strategy for gastric cancer. Cancer Prev Res; 9(3); 253–63. ©2016 AACR.
Clinical and Procedural Predictors of Outcomes From the Endovascular Treatment of Posterior Circulation Strokes
Authors: Mokin Maxim , Sonig Ashish , Sivakanthan Sananthan , Ren Zeguang , Elijovich Lucas , Arthur Adam , Goyal Nitin , Kan Peter , Duckworth Edward , Veznedaroglu Erol , Binning Mandy J. , Liebman Kenneth M. , Rao Vikas , Turner Raymond D. , Turk Aquilla S. , Baxter Blaise W. , Dabus Guilherme , Linfante Italo , Snyder Kenneth V. , Levy Elad I. , Siddiqui Adnan H. 
Published: February 2016

Background and Purpose—
Patients with posterior circulation strokes have been excluded from recent randomized endovascular stroke trials. We reviewed the recent multicenter experience with endovascular treatment of posterior circulation strokes to identify the clinical, radiographic, and procedural predictors of successful recanalization and good neurological outcomes.

Methods—
We performed a multicenter retrospective analysis of consecutive patients with posterior circulation strokes, who underwent thrombectomy with stent retrievers or primary aspiration thrombectomy (including A Direct Aspiration First Pass Technique [ADAPT] approach). We correlated clinical and radiographic outcomes with demographic, clinical, and technical characteristics.

Results—
A total of 100 patients were included in the final analysis (mean age, 63.5±14.2 years; mean admission National Institutes of Health Stroke Scale score, 19.2±8.2). Favorable clinical outcome at 3 months (modified Rankin Scale score ≤2) was achieved in 35% of patients. Successful recanalization and shorter time from stroke onset to the start of the procedure were significant predictors of favorable clinical outcome at 90 days. Stent retriever and aspiration thrombectomy as primary treatment approaches showed comparable procedural and clinical outcomes. None of the baseline advanced imaging modalities (magnetic resonance imaging, computed tomographic perfusion, or computed tomography angiography assessment of collaterals) showed superiority in selecting patients for thrombectomy.

Conclusions—
Time to the start of the procedure is an important predictor of clinical success after thrombectomy in patients with posterior circulation strokes. Both stent retriever and aspiration thrombectomy as primary treatment approaches are effective in achieving successful recanalization.
Intimate partner violence–related experiences and mental health among college students in Japan, Singapore, South Korea and Taiwan
Authors: Kamimura Akiko , Nourian Maziar M , Assasnik Nushean , Franchek-Roa Kathy 
Published: February 2016

Background: Intimate partner violence (IPV) is a significant public health threat that contributes to a wide range of mental and physical health problems for victims. Aims: The purpose of this study was to examine IPV-related experiences and mental health outcomes among college students in Japan, Singapore, South Korea and Taiwan. Methods: The data were obtained from the Inter-University Consortium for Political and Social Research (ICPSR), the International Dating Violence Study (IDVS) 2001–2006 (ICPSR 29583; N = 981; Japan n = 207; Singapore n = 260; South Korea n = 256; Taiwan n = 258). Results: Co-experience of physical IPV victimization and perpetration was associated with borderline personality traits and posttraumatic stress disorder (PTSD), but not with depression. Childhood sexual abuse, gender hostility and violence socialization were significant predictors of borderline personality traits, depression and PTSD. While country and gender variations in mental health are noted, there are two specific populations that may need special attention for mental health interventions: Taiwanese women especially for borderline personality traits and PTSD, and Japanese men especially for depression. Conclusion: IPV victimization and perpetration, childhood sexual abuse, gender hostility and violence socialization have a significant impact on the mental health of college students in Japan, Singapore, South Korea and Taiwan. Since IPV and mental health are significant public health issues, research on IPV and mental health consequences of IPV victimization and perpetration in these countries should be further expanded in order to better understand the interventions that will be effective in treating victims, perpetrators and victim/perpetrators of IPV.
Against the rule of man: the Confucian and Western traditions of good administration
Authors: Yang Lijing , Rutgers Mark R 
Published: February 2016

This article investigates the Confucian and Western traditions specifically with regard to the relation between morality, law and good administration. It is argued that the common opposition between the rule of man and the rule of law as reflecting the basic difference between the two traditions is inadequate. Confucianism can be better characterized positively as the rule of morality. It should also be noticed that ‘the rule of law’ is increasingly being introduced into the Chinese administration. Similarly, even though the Western tradition can be summarized in terms of the rule of law, it is acknowledged that ‘the rule of man’ cannot be avoided, and that morality is important. Both traditions oppose the rule of man, in as far as it refers to someone acting out his selfish preferences. It is concluded that good administration requires officials with both good morality and respect for the law; whether this is a kind of convergence is a matter of debate. Points for practitioners This article studies Confucian and Western administrative traditions in relation to the notion of good administration. It is argued that the common characterization and understanding of the Confucian tradition in terms of the Western reviled ‘rule of man’ is misguided. Rather than understanding the positive moral connotations of the Confucian good administrator it associates them with a specific negative notion; at the same time, overstressing the Western ‘rule of law’ may obscure the need for moral persons for good administration.