bluuebunny/crossref_metadata_2025_split huggingface dataset:
Return to work in heart failure patients with suspected viral myocarditis
Authors: Reibis Rona , Kühl Uwe , Salzwedel Annett , Rasawieh Mortesa , Eichler Sarah , Wegscheider Karl , Völler Heinz 
Published: December 2017

Background: Endomyocardial biopsy is considered as the gold standard in patients with suspected myocarditis. We aimed to evaluate the impact of bioptic findings on prediction of successful return to work. Methods: In 1153 patients (48.9 ± 12.4 years, 66.2% male), who were hospitalized due to symptoms of left heart failure between 2005 and 2012, an endomyocardial biopsy was performed. Routine clinical and laboratory data, sociodemographic parameters, and noninvasive and invasive cardiac variables including endomyocardial biopsy were registered. Data were linked with return to work data from the German statutory pension insurance program and analyzed by Cox regression. Results: A total of 220 patients had a complete data set of hospital and insurance information. Three quarters of patients were virus-positive (54.2% parvovirus B19, other or mixed infection 16.7%). Mean invasive left ventricular ejection fraction was 47.1% ± 18.6% (left ventricular ejection fraction <45% in 46.3%). Return to work was achieved after a mean interval of 168.8 ± 347.7 days in 220 patients (after 6, 12, and 24 months in 61.3%, 72.2%, and 76.4%). In multivariate regression analysis, only age (per 10 years, hazard ratio, 1.27; 95% confidence interval, 1.10–1.46; p = 0.001) and left ventricular ejection fraction (per 5% increase, hazard ratio, 1.07; 95% confidence interval, 1.03–1.12; p = 0.002) were associated with increased, elevated work intensity (heavy vs light, congestive heart failure, 0.58; 95% confidence interval, 0.34–0.99; p < 0.049) with decreased probability of return to work. None of the endomyocardial biopsy–derived parameters was significantly associated with return to work in the total group as well as in the subgroup of patients with biopsy-proven myocarditis. Conclusion: Added to established predictors, bioptic data demonstrated no additional impact for return to work probability. Thus, socio-medical evaluation of patients with suspected myocarditis furthermore remains an individually oriented process based primarily on clinical and functional parameters.
A RandomizEd trial of ENtERal Glutamine to minimIZE thermal injury (The RE-ENERGIZE Trial): a clinical trial protocol
Authors: Heyland Daren K. , Wischmeyer Paul , Jeschke Marc G. , Wibbenmeyer Lucy , Turgeon Alexis F. , Stelfox Henry T. , Day Andrew G. , Garrel Dominique 
Published: December 2017

Background: Burn injury represents a significant public health problem worldwide. More than in any other injury, the inflammation and catabolism associated with severe burns can exacerbate nutrient deficiencies resulting in impaired immune function and increased risk of developing infection, organ dysfunction and death. Consequently, over the last few decades numerous trials have evaluated the impact of different nutritional strategies in severe burn injury. Glutamine is of particular interest, as it appears vital for a number of key stress-response pathways in serious illness. The purpose of the current manuscript is to provide the rationale and protocol for a large clinical trial of supplemental enteral glutamine in 2700 severe burn-injured patients. Methods: We propose a multicentre, double-blind, pragmatic, randomized, clinical trial involving 80 tertiary intensive care unit (ICU) burn centres worldwide. We aim to enrol patients with deep second- and/or third-degree burns at moderate or high risk for death. We will exclude patients admitted > 72 h before screening and patients with advanced liver and kidney disease. The study intervention consists of enteral glutamine 0.5 g/kg/day vs. isocaloric maltodextran control delivered enterally. Primary outcome will be six-month mortality. Key secondary outcomes include time to discharge alive from hospital, ICU and hospital mortality, length of stay and health-related quality of life at six months. Significance: This study will be the first large international multicentre trial examining the effects of glutamine in burn patients. Negative or positive, the results of this trial will inform the clinical practice of burns care worldwide. Clinicaltrials.gov ID #NCT00985205
Assessing Historic Places Regarding Risks and Vulnerabilities Associated with Climate Change to Inform Conservation Planning—Development of Assessment Methods in Northern Europe
Authors: Hermann Carsten 
Published: December 2017

In the face of anthropogenic climate change, the management of cultural heritage must change the world over, in order to adapt historic places to the resulting impacts. Concepts for climate change mitigation and adaptation are well developed, but their application specifically in the context of the historic environment is limited. The number of methods and tools to assess the risks of climate change impacts on historic places and the vulnerabilities of these places to these risks is still small. In this article, three assessment methods will be discussed, which were developed through projects in Northern Europe: Cultural and Heritage Added Value to Regional Policies for Tourism and Sustainability (CHARTS) disseminated a risk and vulnerability assessment to investigate the impacts of climate change on the historic environment of Wales. The Aurland project, in Norway, piloted a site-specific assessment method through local and expert input. Historic Environment Scotland (HES) is reviewing its portfolio of historic places with a novel impact assessment and mapping method, using a geographical information system (GIS). This article discusses the differences of the approaches chosen by the projects to assess climate change impacts and plan adaptation measures. The article concludes with outlining a recently started project, Adapt Northern Heritage, involving HES and two Aurland partners, Riksantikvaren and the Norsk institute for kulturminneforskning, as well as Minjastofnun Íslands.
Breathing training for dysfunctional breathing in asthma: taking a multidimensional approach
Authors: Courtney Rosalba 
Published: December 2017

Various breathing training programmes may be helpful for adults with asthma. The main therapeutic aim for many of these programmes is the correction of dysfunctional breathing. Dysfunctional breathing can be viewed practically as a multidimensional entity with the three key dimensions being biochemical, biomechanical and psychophysiological. The objectives of this review are to explore how each of these dimensions might impact on asthma sufferers, to review how various breathing therapy protocols target these dimensions and to determine if there is evidence suggesting how breathing therapy protocols might be optimised.Databases and reference lists of articles were searched for peer-reviewed English language studies that discussed asthma or dysfunctional breathing and various breathing therapies.Biochemical, biomechanical and psychophysiological aspects of dysfunctional breathing can all potentially impact on asthma symptoms and breathing control. There is significant variation in breathing training protocols and the extent to which they evaluate and improve function in these three dimensions.The various dimensions of dysfunctional breathing may be of greater or lesser importance in different cases and the effectiveness of breathing training protocols is likely to be improved when all three dimensions are considered. Outcomes for breathing training for dysfunctional breathing in asthma may be most successful when the three key dimensions of dysfunctional breathing are evaluated at the start of treatment and monitored during treatment. This allows breathing training protocols to be adjusted as appropriate to ensure that treatment is sufficiently comprehensive and intensive to produce measurable improvements where necessary.
A CK1 FRET biosensor reveals that DDX3X is an essential activator of CK1ε
Authors: Dolde Christine , Bischof Joachim , Grüter Simon , Montada Anna , Halekotte Jakob , Peifer Christian , Kalbacher Hubert , Baumann Ulrich , Knippschild Uwe , Suter Beat 
Published: December 2017

ABSTRACT
Casein kinase 1 (CK1) plays central roles in various signal transduction pathways and performs many cellular activities. For many years CK1 was thought to act independently of modulatory subunits and in a constitutive manner. Recently, DEAD box RNA helicases, in particular DEAD box RNA helicase 3 X-linked (DDX3X), were found to stimulate CK1 activity in vitro. In order to observe CK1 activity in living cells and to study its interaction with DDX3X, we developed a CK1-specific FRET biosensor. This tool revealed that DDX3X is indeed required for full CK1 activity in living cells. Two counteracting mechanisms control the activity of these enzymes. Phosphorylation by CK1 impairs the ATPase activity of DDX3X and RNA destabilizes the DDX3X–CK1 complex. We identified possible sites of interaction between DDX3X and CK1. While mutations identified in the DDX3X genes of human medulloblastoma patients can enhance CK1 activity in living cells, the mechanism of CK1 activation by DDX3X points to a possible therapeutic approach in CK1-related diseases such as those caused by tumors driven by aberrant Wnt/β-catenin and Sonic hedgehog (SHH) activation. Indeed, CK1 peptides can reduce CK1 activity.
MARCKS-related protein regulates cytoskeletal organization at cell–cell and cell–substrate contacts in epithelial cells
Authors: Van Itallie Christina M. , Tietgens Amber Jean , Aponte Angel , Gucek Marjan , Cartagena-Rivera Alexander X. , Chadwick Richard S. , Anderson James M. 
Published: December 2017

ABSTRACT
Treatment of epithelial cells with interferon-γ and TNF-α (IFN/TNF) results in increased paracellular permeability. To identify relevant proteins mediating barrier disruption, we performed proximity-dependent biotinylation (BioID) of occludin and found that tagging of MARCKS-related protein (MRP; also known as MARCKSL1) increased ∼20-fold following IFN/TNF administration. GFP–MRP was focused at the lateral cell membrane and its overexpression potentiated the physiological response of the tight junction barrier to cytokines. However, deletion of MRP did not abrogate the cytokine responses, suggesting that MRP is not required in the occludin-dependent IFN/TNF response. Instead, our results reveal a key role for MRP in epithelial cells in control of multiple actin-based structures, likely by regulation of integrin signaling. Changes in focal adhesion organization and basal actin stress fibers in MRP-knockout (KO) cells were reminiscent of those seen in FAK-KO cells. In addition, we found alterations in cell–cell interactions in MRP-KO cells associated with increased junctional tension, suggesting that MRP may play a role in focal adhesion-adherens junction cross talk. Together, our results are consistent with a key role for MRP in cytoskeletal organization of cell contacts in epithelial cells.
The opercular mouth-opening mechanism of largemouth bass functions as a 3D four-bar linkage with three degrees of freedom
Authors: Olsen Aaron M. , Camp Ariel L. , Brainerd Elizabeth L. 
Published: December 2017

ABSTRACT
The planar, one degree of freedom (1-DoF) four-bar linkage is an important model for understanding the function, performance and evolution of numerous biomechanical systems. One such system is the opercular mechanism in fishes, which is thought to function like a four-bar linkage to depress the lower jaw. While anatomical and behavioral observations suggest some form of mechanical coupling, previous attempts to model the opercular mechanism as a planar four-bar have consistently produced poor model fits relative to observed kinematics. Using newly developed, open source mechanism fitting software, we fitted multiple three-dimensional (3D) four-bar models with varying DoF to in vivo kinematics in largemouth bass to test whether the opercular mechanism functions instead as a 3D four-bar with one or more DoF. We examined link position error, link rotation error and the ratio of output to input link rotation to identify a best-fit model at two different levels of variation: for each feeding strike and across all strikes from the same individual. A 3D, 3-DoF four-bar linkage was the best-fit model for the opercular mechanism, achieving link rotational errors of less than 5%. We also found that the opercular mechanism moves with multiple degrees of freedom at the level of each strike and across multiple strikes. These results suggest that active motor control may be needed to direct the force input to the mechanism by the axial muscles and achieve a particular mouth-opening trajectory. Our results also expand the versatility of four-bar models in simulating biomechanical systems and extend their utility beyond planar or single-DoF systems.
THE PECULARITIES OF THE USAGE OF INFORMATIONAL AND COMMUNICATIONAL TECHNOLOGIES (ICT) IN THE EDUCATIONAL PROCESS OF MEDICAL EDUCATIONAL INSTITUTIONS
Authors: Гадаева Виктория , Gadaeva Viktoria 
Published: December 2017

The age of computer technologies is achieving a good pace, and already there is no area of human activity where they would not find their application.
In today's reality of the learning process, the issue of modernization is very relevant, but it also stresses the necessity of changing methods and technologies of teaching at all levels, improving weight of those that form practical skills of analysis of information, learning, stimulate independent work of students, shape the experience of responsible choice and responsibility. The necessity arose for a new model of learning based on modern information technologies, implementing the principles of personality-oriented education
Person-centred care—a 2017 framework
Authors: Mullen Chris 
Published: December 2017

This article describes the context and development of ‘person-centred’ as a fundamental principle underpinning how practitioners work with patients and their families. Across the UK, person-centred care has become a key component of health policy and system reform. It is increasingly being included in education and training programmes and in role descriptors for practitioners in healthcare. This article presents a recent person-centred framework from Health Education England, Skills for Health and Skills for Care that aims to support and equip staff and organisations with the skills, knowledge and behaviours required to embed person-centred approaches.
Outpatient induction of labour with prostaglandins: Safety, effectiveness and women's views
Authors: Smith Lisa Kirsten 
Published: December 2017

Background Nearly 28% of women underwent induction of labour in England in 2015-16. Women frequently report delays and poor experiences, and the process can put additional pressure on busy labour wards. Outpatient induction of labour (OPIOL) enables women to return home to await the onset of contractions. Aim To explore the research about OPIOL using prostaglandins and to identify gaps in the evidence base. Outcomes will be compared with those induced as inpatients. Method An electronic search was conducted to identify relevant studies using keywords. Once the studies had been identified, a narrative synthesis of the findings was conducted. Findings Adverse outcomes were rare but studies were not sufficiently powered to detect significant differences between outpatients and inpatients. There were some differences in cost and effectiveness that may be explained by disparities in study design, participant characteristics and operational issues. Time avoided in hospital by outpatients ranged from 7.5–11.76 hours. Satisfaction was generally higher with OPIOL, although some women expressed apprehension about being at home. Conclusion While OPIOL with prostaglandins is acceptable to women, it is not clear whether there are significant differences in safety and effectiveness outcomes, due to the low frequency of adverse perinatal events as well as methodological and quality issues of the included studies. Further research is needed to compare outcomes, maternal experiences and cost effectiveness of OPIOL.
Arthroscopic remplissage
Authors: Morsy Mohamed G. 
Published: December 2017

Posterolateral humeral head defects can be large and engage on the anterior glenoid, and they usually contribute to anterior shoulder instability in 40% to 90% of cases. The purpose of this study is to evaluate the results of the largest series of patients who underwent arthroscopic remplissage with Bankart repair for recurrent anterior shoulder instability due to associated Bankart lesions, with large and engaging (> 25% involvement) humeral Hill-Sachs defects (HSDs). A total of 51 patients underwent arthroscopic Bankart repair with remplissage technique for the treatment of recurrent anterior glenohumeral instability with large and medial HSDs. Pre-operative imaging in all patients identified a Bankart lesion with an associated HSD that involved > 25% of the humeral head. The Rowe score was used to assess the patients clinically. A total of 46 patients were male. The mean age of the patients was 28.7 years (18 to 43). The mean follow-up period was 31 months (20 to 39). At the final follow-up, three patients reported recurrence of instability (two dislocations and one subluxation). The mean Rowe score improved to 95.4 points (function, 45.5 of 50; stability, 26.4 of 30; motion, 8 of 10; pain, 8 of 10). The arthroscopic remplissage technique with Bankart repair gave satisfactory results and is still considered to be an effective, safe and reliable procedure for treatment of glenohumeral instability in cases with large and medial HSDs. Cite this article: EFORT Open Rev 2017;2:478–483. DOI: 10.1302/2058-5241.2.160070
Effect of processing methods on nutrient and tannin content of tamarind seeds
Authors: LY JOHANIS , SJOFJAN OSFAR , DJUNAIDI IRFAN H. , SUYADI SUYADI 
Published: December 2017

Ly J, Sjofjan O, Djunaidi IH, Suyadi.2017. Effect of processing methods on nutrient and tannin content of tamarind seeds. Trop Drylands 1: 78-82.The study aimed at evaluating the nutrient content and effect of physical processing methods on nutrient and tannin content of Indonesia’s tamarind seeds. There were four treatments allotted in this experiment following a completely randomized design: sun-dried seeds (T0), dry fried/roasted seeds (T1), moistening12 hours (T2) and 24 hours (T3) ground dry fried/roasted tamarind seeds kernel. Dry frying increased significantly (P<0.05) CP, EAA, and NEAA but reduced (P<0.05) CF; fat, SAFA, UFA and tannin contents of sun-dried tamarind seeds. Moistening 12-24 hours improved significantly (P<0.5) CP, SAFA, UFA; reduced (P<0.5) fat; CF; EAA, NEAA; and released 7-8.5% additional tannin contents of ground dry fried seeds kernel. The study highlighted that the Indonesia’s semiarid region tamarind seeds contain comprehensive nutrients and tannin compound. Dry frying, dehusked tamarind seeds and grinding followed by moistening the ground dry fried seeds’ kernel could eliminate tannin compound and improve the nutrient content of tamarind seeds kernel.
Online Orchestra: Connecting remote communities through music
Authors: Rofe Michael , Murray Samuel , Parker Will 
Published: December 2017

Abstract
Online Orchestra is a telematic performance project, aimed at enabling young and amateur musicians in geographically remote locations to make music together over the Internet. This article describes the contexts out of which the project emerged, including an overview of the benefits of ensemble performance, and a survey of precedent telematic performance projects. It goes on to describe how the starting premises of Online Orchestra respond to these contexts and ends with a summary of Online Orchestra’s approach, and its key findings. The article describes in particular how many recent telematic performance projects rely on specialist networks and equipment, and that alternative design solutions are necessary, and possible, in order to reach young and amateur musicians in their own remote locations.
Socratic Euporia and Aporia in the Lysis
Authors: Yonezawa Shigeru 
Published: December 2017

AbstractIn theLysisSocrates deals with the problem of what is a friend and what is friendship. After giving an introduction and a synopsis of theLysisin section one, I explain, in section two, Socrates’ view that a true friend is “what is akin” or “what is belonging to oneself” (oikeion) which is what is taken from oneself and discovered in another person. When this happens among two persons, they become friends to each other. The content of what is akin is either a good characteristic or ways or form of the soul. Friendship is the desire for what is akin. In section three I show that Socrates remains inaporiawhile he faces several problems. Unless he is able to answer such problems, he will not be truly confident about what is a friend. In section four I deal with and refute Penner’s and Rowe’s view that a true friend means wisdom. In section five I examine the view of friendship which occurs among people who share common deficit. As a conclusion, in section six, I reflect on the significance of my interpretation and the role of theLysisin Plato’s philosophy.
An Overlooked Fragment of Parmenides in Proclus?
Authors: Kurfess Christopher 
Published: December 2017

AbstractI propose that a quotation appearing in Proclus’ commentary on Plato’s Timaeus, and attributed by Proclus to Parmenides, preserves an independent fragment of Parmenides’ poem. Because the verses quoted share language familiar from other Parmenidean and Empedoclean lines, scholars have regarded Proclus’ quotation as a conflation of lines by Parmenides and Empedocles, but when due allowance is made for the repetitiousness of Parmenides’ poetry and for Empedocles’ borrowings from Parmenides, there is no reason to assume any confusion on Proclus’ part.
Empty Negations and Existential Import in Aristotle
Authors: Corkum Phil 
Published: December 2017

AbstractAristotle draws what are, by our lights, two unusual relationships between predication and existence. First, true universal affirmations carry existential import. If ‘All humans are mortal’ is true, for example, then at least one human exists. And secondly, although affirmations with empty terms in subject position are all false, empty negations are all true: if ‘Socrates’ lacks a referent, then both ‘Socrates is well’ and ‘Socrates is ill’ are false but both ‘Socrates is not well’ and ‘Socrates is not ill’ are true. In this paper, I conjecture that for Aristotle predications have mereological truth conditions: for example, ‘Socrates is pale’ is true just in case Socrates is a part of the mereological sum of pale things. The existential import of universal affirmations and the semantic profile of empty negations follow from this mereological semantics.