bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical efficacy and safety of a silver ion-releasing foam dressing on hard-to-heal wounds: a meta-analysis
Authors: Münter Karl-Christian , Lázaro-Martínez José Luis , Kanya Susanne , Sawade Linda , Schwenke Carsten , Pegalajar-Jurado Adoracion , Swanson Terry , Leaper David 
Published: October 2024

Objective: Delayed or stalled healing in open wounds can result from persisting chronic inflammation related to infection and/or persistent bacterial colonisation and biofilm. Treatment of hard-to-heal wounds focuses on debridement and exudate management, but also on infection prevention and control. Silver dressings have been evaluated in randomised clinical trials (RCTs); this meta-analysis evaluated the efficacy and safety of a silver ion-releasing foam dressing (Biatain Ag; Coloplast A/S, Denmark) to treat hard-to-heal wounds. Method: Literature databases (PubMed and Cochrane Library) were searched for studies on silver ion-releasing foam dressings in the treatment of hard-to-heal wounds. Individual patient data from four RCTs were obtained and included in the meta-analysis. Results: Findings showed that treatment with the silver ion-releasing foam dressing was associated with a significantly higher relative reduction in wound area after four (least squares-mean difference (LS-MD): –12.55%, 95% confidence interval (CI): (–15.95, –9.16); p<0.01) and six weeks of treatment (LS-MD: –11.94%, 95%CI: (–17.21, –6.68); p<0.01) compared with controls. Significant benefits were also observed for time to disappearance of odour (hazard ratio: 1.61, 95%CI: (1.31, 1.98); p<0.01), relative reduction of exudate (LS-MD: –5.15, 95%CI: (–7.36, –2.94); p<0.01), proportion of patients with periwound erythema (relative risk (RR): 0.81, 95%CI: (0.69; 0.94); p<0.01), and less pain at dressing removal (LS-MD: –0.35, 95%CI: (–0.63, –0.06); p=0.02). No differences regarding safety outcomes were identified. Conclusion: This meta-analysis has demonstrated beneficial outcomes and a good tolerability profile for silver ion-releasing foam dressings in the treatment of moderate-to-highly exuding wounds with delayed healing compared with control dressings.
Expression of PD-L1 in breast invasive lobular carcinoma
Authors: Shin Eunah , Kim Hye Min , Koo Ja Seung 
Published: October 2024

Purpose
The purpose of this study was to investigate the expression of PD-L1 in invasive lobular carcinoma (ILC) and to determine its implications.

Methods
Tissue microarrays were constructed for 101 cases of ILC, and immunohistochemical staining for PD-L1 (using 22C3, SP142, and SP263 antibodies) was performed to examine the correlation between staining results and clinicopathologic parameters.

Results
The positive cut-off values were defined as tumor cell (TC)≥1%, immune cell (IC)>0%, and IC≥1%. The range of PD-L1 TC positivity was 0.0–2.0%, with PD-L1 SP263 TC showing the highest positivity of 2.0%. The range of PD-L1 IC positivity was 0–21.8% for IC ≥ 1%, with PD-L1 22C3 IC showing the highest positivity. When PD-L1 IC was positive (IC≥1%), the highest antibody agreement was observed between SP263 and SP142 (OA = 93.1%), while the lowest agreement was observed between 22C3 and SP263 (OA = 73.3%, κ = 0.040). PD-L1 22C3 IC positivity (≥1%) was associated with high nuclear grade (p = 0.002), HER-2 positivity (p = 0.019), and pleomorphic type (p = 0.002).

Conclusion
PD-L1 expression in ILC shows a low TC positivity rate (0–2%) with various antibody clones and a variable IC positivity rate (0–21.8%). Pleomorphic type ILC exhibits higher PD-L1 IC positivity.
The influence of age, gender and pharmacogenetic profiles on the perspective on medicines in the German EMPAR study
Authors: Atemnkeng Ntam Veronica , Huebner Tatjana , Steffens Michael , Roethlein Christoph , Haenisch Britta , Stingl Julia , Linder Roland , Scholl Catharina 
Published: October 2024

Background
Pharmacogenetic testing in routine care could provide benefits for patients, doctors and statutory health insurances. Therefore, the aim of the retrospective, observational study Einfluss metabolischer Profile auf die Arzneimitteltherapiesicherheit in der Routineversorgung (EMPAR) was to analyze the relationship between pharmacogenetic profiles, the risk of adverse drug reactions, and patients’ perceptions of drug therapy in 10748 adult (≥18 years) participants in Germany.

Methods
A questionnaire was used to assess views and beliefs about medicines and participants individual perception of sensitivity to drug therapies. The questionnaire consisted of the Beliefs about Medicines Questionnaire (BMQ)-General scales (Overuse, Harm, Benefit), the Perceived Sensitivity to Medicines (PSM), Natural Remedy, and Gene Testing scales. The influence of gender, age, study collective, genotype and phenotype of relevant pharmacogenes on participant’s perception were evaluated.

Results
Overuse, PSM and Benefit scores were significantly higher among patients of the collective International Classification of Diseases and Health Related Disorders (ICD)-10 Y57.9! diagnosis, which indicates complications related to drugs, compared to the anticoagulant/antiplatelet and cholesterol-lowering drug collective. Age and gender also played a significant role in patients’ perceptions, with younger patients and female participants more likely to believe in medication overuse according to the Overuse scale score compared to older and male participants. Female participants compared to male participants and the old age group compared to the young and/or middle-age subgroup, scored higher in PSM and/or Harm scales, respectively. Only a tendency of increased Harm, Overuse and PSM scores was observed in the participant group with five or more relevant actionable variants compared to subgroups with 0 up to 4 variants.

Conclusions
In conclusion, patients’ beliefs about medicines and their drug sensitivity perceptions are influenced by various factors including age, gender, previous complications with medicines, and with some tendency also pharmacogenetic profiles. The higher association with more negative views related to treatment indicates that there is a need to target the underlying issues in affected patient groups in order to improve compliance to treatment and outcomes in routine care.
Trial registration: EMPAR was registered in the German Clinical Trials Register (DRKS) on 06 July 2018 (DRKS00013909).
Noncommunicable disease behavioral risk factors in Sub Saharan Africa: A protocol of systematic review and meta-analysis
Authors: Kassa Assefa Andargie , Zewdie Segenet , Taddele Mekuanint 
Published: October 2024

Background
The most frequent risks of noncommunicable diseases include tobacco use, harmful use of alcohol, unhealthy diet, and physical inactivity. In low-income countries, it is not fully understood how serious these risk factors are. To address the issue at the risk factor level, it is essential to produce evidence that aids in the development of policies and initiatives in the area. This review is aimed to estimate the pooled prevalence of noncommunicable disease behavioral risk factors in Sub-Saharan Africa.

Methods
Studies published between 2016 and 2023 will be located using searches of the electronic databases PubMed, CINAHL, and African Index Medicus as well as Google and Google Scholar. Two authors will independently review the records, and information will be taken from studies that present statistics on the prevalence of tobacco use, alcohol use, unhealthy diet, and insufficient physical activity among people older than 18 years. Using the I2 and Q statistics, heterogeneity between studies will be evaluated, and it will be investigated using subgroup analyses and meta-regressions. Random effects meta-analysis model will be used and subgroup analysis will be performed by country, study design, and study year.

Discussion
The burden of noncommunicable disease risk factors varies throughout the Sub-Saharan Africa. The review will be essential for both research and policy. The finding may even help to identify settings or subgroups of the population where noncommunicable diseases is of higher concern and help to set prevention priorities, to optimize resource allocation, and guide future research to fill knowledge gaps. The protocol has been registered in PROSPERO (CRD42023431348).
Clinical impact of ceruloplasmin levels at ANCA-associated vasculitis diagnosis
Authors: Camboulive Louis , Grandhomme Frédérique , Martin Silva Nicolas , Khoy Kathy , Mariotte Delphine , Lobbedez Thierry , Dumont Anaël , Nguyen Alexandre , de Boysson Hubert , Aouba Achille , Deshayes Samuel 
Published: October 2024

Objectives
Ceruloplasmin is an inhibitor of myeloperoxidase (MPO) activity that plays an important role in the pathophysiology of anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV). This study aimed to evaluate the prognostic impact of serum level of ceruloplasmin at diagnosis in patients with anti-MPO antibody-positive AAV.

Methods
This retrospective monocentric study in Caen University Hospital involved all consecutive adult anti-MPO antibody-positive patients with microscopic polyangiitis or granulomatosis with polyangiitis, diagnosed between January 2010 and January 2022 with available serum sample at inclusion. Patients outcomes were analyzed from two subgroups constituted according to the median serum level of ceruloplasmin. The same analyses were then performed in anti-proteinase 3 (PR3) antibody-positive patients.

Results
Within the 92 patients analyzed, 50 patients had anti-MPO antibodies with a median ceruloplasmin level of 0.44 [quartiles 1–3, 0.40–0.49] g/L and a median Birmingham Vasculitis Activity Score of 19 [14–22]. After a median follow-up period of 40 [22–86] months, 13 (26%) patients had died: 10 (40%) in the low ceruloplasmin group and 3 (12%) in the high ceruloplasmin group (p = 0.03), with a significantly worse survival rate in the low ceruloplasmin group (p = 0.021). No significant differences in relapse rate or renal failure was observed between the two groups. The same analyses performed in the group of AAV patients with anti-PR3 antibody did not show any differences.

Conclusion
In anti-MPO AAV patients, serum level of ceruloplasmin at diagnosis seems to be associated with a significant impact on survival.
Enteropathy-Associated T-Cell Lymphoma Treated With Autologous Hematopoietic Stem-Cell Transplant: A Glimmer of Hope?
Authors: Gahra Amrit , Katrevula Anudeep , Sekaran Anuradha , Wanve Balasaheb , Reddy Katukuri Goutham , Lakhtakia Sundeep , Duvvur Nageshwar Reddy 
Published: October 2024

ABSTRACT
We report a case of primary enteropathy-associated T-cell lymphoma in a 50-year-old man presenting with abdominal pain, chronic diarrhea, and significant weight loss over 6 months. Diagnosis was confirmed through endoscopy, biopsy, and positron emission tomography-computed tomography, staging the disease as stage 1E. The patient underwent initial treatment with the cyclophosphamide, doxorubicin (also known as hydroxydaunorubicin), vincristine (also known as oncovin), etoposide, and prednisolone chemotherapy regimen, followed by high-dose hyper-fractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone chemotherapy and autologous stem cell transplantation. Despite developing febrile neutropenia and septic shock during treatment, the patient achieved disease remission and symptom resolution. This case underscores the potential of autologous stem-cell transplantation as a curative approach for primary enteropathy-associated T-cell lymphoma and highlights the need for further research on its effectiveness.
An Infiltrative Case of Angiosarcoma Causing Portal Hypertension
Authors: Bae Gina , Dunleavy Katie A. , Hagen Catherine , Simonetto Douglas A. , Abdelmalek Manal F. 
Published: October 2024

ABSTRACT
Hepatic angiosarcoma is a rare and aggressive liver tumor. We report a case study of an 82-year-old elderly gentleman who presented with failure to thrive and ascites. Initially suspected to be cirrhosis, biopsy results eventually concluded angiosarcoma of the liver. Our patient presented with an infiltrative form, rather than distinct masses, which led to portal hypertension and ascites. The variance in symptomatology and radiology presentations make a diagnosis of hepatic angiosarcoma challenging and require a high index of suspicion.
Impact of Using Self-Assembling Peptide (PuraStat) on Anastomotic Ulcers—A Multicenter Case Series
Authors: Oza Veeral M. , Mittal Nitish , Winchester Charles , Fazel Yousef , Manvar Amar , Goodman Adam , Girotra Mohit , Khara Harshit S. , Kothari Shivangi , Kothari Truptesh H. 
Published: October 2024

ABSTRACT
Treatment of anastomotic ulcers, also known as marginal ulcers, is challenging, especially when established techniques have failed. PuraStat is a biocompatible synthetic peptide gel that is indicated for hemostasis of bleeding in the gastrointestinal tract and vascular anastomoses. We aim to evaluate the feasibility of PuraStat in the setting of nonhealing anastomotic ulcers when used alongside standard therapies. This is a multicenter case series of adult patients who had PuraStat applied with a follow-up repeat endoscopy. Nine out of 10 patients showed clinical improvement. We concluded that PuraStat is an effective agent to aid in healing of anastomotic ulcer.
Avaliação: uma questão filosófica
Authors: Dalberio Oswaldo 
Published: October 2024

Para se fazer uma avaliação devem ser considerados vários elementos constituintes do processo de aprendizado. A saber: aquisição de conteúdo programático, capacidade de reflexão e partir de conceituação teórica e científica, aplicação da teoria na práxis intelectual, ou seja, na produção científica de conhecimento, ato-avaliação do processo de envolvimento no conteúdo e na reflexão filosófica. Sabemos dos problemas enfrentados tanto pelo professor quanto pelo estudante, na aquisição de conteúdo filosófico. Primeiro é a educação global, ou seja, os primeiro e segundo graus mal feitos gerando a falta de capacidade em aprofundar questões, pensar uma dada realidade e mais ainda posicionar-se frente à política, à economia, à sociedade e à própria percepção de mundo, a cosmovisão. O professor tem que assumir o papel de mágico, ao mesmo tempo transmitir conteúdo e ensinar pressupostos elementares que já deveriam ser do domínio do aluno. Partindo daí fica defasado o processo de aquisição: primeiro o ensinar a pensar, segundo como pensar, o que pensar e o de onde pensar. [...]
Palavras-chave: Avaliação; Aprendizado; Práxis; Reflexão filosófica.
Electrical stimulation of biofidelic engineered muscle enhances myotube size, force, fatigue resistance, and induces a fast‐to‐slow‐phenotype shift
Authors: Pallotta Isabella , Stec Michael J. , Schriver Brian , Golann David R. , Considine Kevin , Su Qi , Barahona Victor , Napolitano Julia E. , Stanley Sarah , Garcia Meghan , Feric Nicole T. , Durney Krista M. , Aschar‐Sobbi Roozbeh , Bays Nathan , Shavlakadze Tea , Graziano Michael P. 
Published: October 2024

AbstractTherapeutic development for skeletal muscle diseases is challenged by a lack of ex vivo models that recapitulate human muscle physiology. Here, we engineered 3D human skeletal muscle tissue in the Biowire II platform that could be maintained and electrically stimulated long‐term. Increasing differentiation time enhanced myotube formation, modulated myogenic gene expression, and increased twitch and tetanic forces. When we mimicked exercise training by applying chronic electrical stimulation, the “exercised” skeletal muscle tissues showed increased myotube size and a contractility profile, fatigue resistance, and gene expression changes comparable to in vivo models of exercise training. Additionally, tissues also responded with expected physiological changes to known pharmacological treatment. To our knowledge, this is the first evidence of a human engineered 3D skeletal muscle tissue that recapitulates in vivo models of exercise. By recapitulating key features of human skeletal muscle, we demonstrated that the Biowire II platform may be used by the pharmaceutical industry as a model for identifying and optimizing therapeutic drug candidates that modulate skeletal muscle function.
Initial boundary value problem and exponential stability for the planar magnetohydrodynamics equations with temperature-dependent viscosity
Authors: Shang Zhaoyang , Yang Erjia 
Published: October 2024

Abstract
In this study, we consider the initial boundary value problem of the planar magnetohydrodynamics (MHD) system when the viscous coefficients and heat conductivity depend on the temperature, which are assumed to be proportional to

θ

α

{\theta }^{\alpha }

,

α
≥
0

\alpha \ge 0

, and

θ

β

{\theta }^{\beta }

,

β
≥
0

\beta \ge 0

, respectively, and magnetic diffusivity coefficient depends on the specific volume. We prove the existence and uniqueness of the global-in-time classical solution with general large initial data provided that

α

\alpha

is sufficiently small and there is no restriction on the parameter

β

\beta

. Moreover, the nonlinearly exponential stability of the solution is obtained. As a result, we extend the works given by Sun et al. for the full compressible Navier-Stokes equations and by Li and Shang for the full compressible MHD equations.
Behavior of trace metals in sedimentary cores from marine and lacustrine environments in Algeria
Authors: Athmani Houria 
Published: October 2024

Abstract
This study highlights the potential risks of pollution due to the presence of trace metals in sediment samples from six sediment cores from four wetlands (Chott Melghir, Fontaine des Gazelles dam, Lake Mellah, and Algiers Bay) in Algeria, assessing the level of contamination of these trace metals, and understanding the behavior of metals as a function of the depth of the sediment cores and the nature of the different sampling media. A total of 130 sediment samples were collected and subjected to chemical analysis (loss on ignition, inductively coupled plasma mass spectrometry, and atomic absorption spectroscopy to determine M.O. and trace metal contents) and physical analysis (X-ray fluorescence and DRX to identify the chemical composition and mineralogy of the sediments). Calculation of the enrichment factor enabled us to differentiate between anthropogenic and natural sources of trace metals such as Zn, Pb, Cr, Ag, and Cd, showing contamination at various sites due to urban or agricultural inputs. The dominant mineralogical composition of the sediments at the four sites was quartz, carbonate, and sandstone. Principal component analysis revealed strong positive correlations in the chemical composition of sediment samples between chlorine and Na2O, K2O, TiO2, Al2O3, and Fe2O, the main components of clays. The presence of organic matter in the four study areas is directly linked to the introduction of organic matter from the wadis into the watershed. Sediments have a high redox activity, which facilitates the movement of trace metals.
Bimagrumab: an investigational human monoclonal antibody against activin type II receptors for treating obesity
Authors: Kaur Manmeet , Misra Saurav 
Published: October 2024

Abstract
Bimagrumab is a human monoclonal antibody that prevents activin type II receptors (ActRII) from functioning. This antibody has a higher affinity for muscle activin-2 receptors than natural ligands such as activin and myostatin, which act as negative muscle growth regulators. Blocking the activin receptor with bimagrumab could be a new pharmaceutical approach for managing patients with obesity and type 2 diabetes mellitus (T2DM). Bimagrumab has anabolic effects on skeletal muscle mass by preventing myostatin binding and other negative muscle growth regulators. Preclinical animal models have also shown that ActRII blockade promotes actions beyond skeletal muscle, including effects on brown adipose tissue (BAT) differentiation and activity. In a phase 2 randomized clinical trial, ActRII blockade with bimagrumab led to significant loss of total body fat mass (FM), lean mass (LM) gain, and metabolic improvements over 48 weeks in overweight or obese patients with type 2 diabetes. The trial involved [number of participants], and the results showed [specific findings]. Currently, Bimagrumab is being evaluated for its potential to treat muscle wasting, functional loss in hip fractures and sarcopenia, as well as obesity. However, it is essential to note that Bimagrumab also blocks the effects of other ActRII ligands, which play a role in the neurohormonal axes, pituitary, gonads, and adrenal glands. These observations suggest that bimagrumab might represent a new approach for treating patients with obesity and related metabolic disturbances.
Atmosphere turbulence effects on a multiple apertures free space optical communication systems
Authors: Shaker Farouk Kh. , Mohammed Firas S. , Khudhair Muntadher J. 
Published: October 2024

Abstract
Wireless communication signals experienced fluctuations in intensity due to atmospheric turbulence. The presented work uses a multi-input-multi-output (MIMO) system to study the performance free-space optical (FSO) communication over a diverse atmospheric turbulence condition channel. The findings produced demonstrate how various channel models perform in FSO system at varying levels of channel turbulence. From 7.9 for the Weak turbulence to 45.3 for the strong turbulence, the turbulence attenuation rises linearly. The data could be transmitted via a link length of up to 1 km with strong turbulence. Strong turbulence could have higher Q-factor, yet is constrained by short distance (1 km) in comparison with weak turbulence, which has greater distance (3.8 km), therefore communication quality is lower. For moderate and weak turbulence, the maximum link is around 1.5 km and 3.8 km, respectively. This study is useful for designing a stable FSO system for regional environments suffer from frequent fluctuated weather turbulence such as the Middle East and South Asia.
‘Aquí toman mucho sopa’: Linguistic variables as predictors of non-standard gender agreement production in Basque Spanish
Authors: Basterretxea Santiso Gorka 
Published: October 2024

Abstract
The language contact between Basque and Spanish in the Basque Autonomous Community (BAC) gives rise to the production of specific linguistic features such as non-standard gender agreement (N-SGA). N-SGA in BAC Spanish has been traditionally attributed to elder Basque native speakers without much access to education, but this affirmation is not based on any empirical study. In addition, although several scholars have explored N-SGA in other language contact situations, there is no agreement on the linguistic factors that favor this production. Taking this knowledge gap as the point of departure, the present study explores 73 individual sociolinguistic interviews by a diverse population from the BAC in order to delimit (i) the community that produces N-SGA and (ii) the linguistic factors that condition it. Results follow Basterretxea Santiso’s (2022, “A triangulation study on gender agreement in Spanish by native Basque speakers.” Revista Española de Lingüística (RSEL) 52(1): 7–37) suggestion that N-SGA in BAC Spanish is present across generations: it is a well-established feature present in BAC Spanish as a result of language contact. Results also support the existence of a local gender agreement system that depends on the gender of the controller, inflectional form, number, distance, and whether the target is a clitic or adjective.