bluuebunny/crossref_metadata_2025_split huggingface dataset:
GSK3-mediated CLASP2 phosphorylation modulates kinetochore dynamics
Authors: Pemble Hayley , Kumar Praveen , van Haren Jeffrey , Wittmann Torsten 
Published: February 2017

ABSTRACT
Error-free chromosome segregation requires dynamic control of microtubule attachment to kinetochores, but how kinetochore–microtubule interactions are spatially and temporally controlled during mitosis remains incompletely understood. In addition to the NDC80 microtubule-binding complex, other proteins with demonstrated microtubule-binding activities localize to kinetochores. One such protein is the cytoplasmic linker-associated protein 2 (CLASP2). Here, we show that global GSK3-mediated phosphorylation of the longest isoform, CLASP2α, largely abolishes CLASP2α–microtubule association in metaphase. However, it does not directly control localization of CLASP2α to kinetochores. Using dominant phosphorylation-site variants, we find that CLASP2α phosphorylation weakens kinetochore–microtubule interactions as evidenced by decreased tension between sister kinetochores. Expression of CLASP2α phosphorylation-site mutants also resulted in increased chromosome segregation defects, indicating that GSK3-mediated control of CLASP2α–microtubule interactions contributes to correct chromosome dynamics. Because of global inhibition of CLASP2α–microtubule interactions, we propose a model in which only kinetochore-bound CLASP2α is dephosphorylated, locally engaging its microtubule-binding activity.
ErbB1 and ErbB4 generate opposing signals regulating mesenchymal cell proliferation during valvulogenesis
Authors: Iwamoto Ryo , Mine Naoki , Mizushima Hiroto , Mekada Eisuke 
Published: February 2017

ABSTRACT
Heparin-binding EGF-like growth factor (HB-EGF) plays an indispensable role in suppression of cell proliferation during mouse valvulogenesis. However, ligands of the EGF receptor (EGFR/ErbB1), including HB-EGF, are generally considered as growth-promoting factors, as shown in cancers. HB-EGF binds to and activates ErbB1 and ErbB4. We investigated the role of ErbB receptors in valvulogenesis in vivo using ErbB1- and ErbB4-deficient mice, and an ex vivo model of endocardial cushion explants. We show that HB-EGF suppresses valve mesenchymal cell proliferation through a heterodimer of ErbB1 and ErbB4, and an ErbB1 ligand (or ligands) promotes cell proliferation through a homodimer of ErbB1. Moreover, a rescue experiment with cleavable or uncleavable isoforms of ErbB4 in ERBB4-null cells indicates that the cleavable JM-A, but not the uncleavable JM-B, splice variant of ErbB4 rescues the defect of the null cells. These data suggest that the cytoplasmic intracellular domain of ErbB4, rather than the membrane-anchored tyrosine kinase, achieves this suppression. Our study demonstrates that opposing signals generated by different ErbB dimer combinations function in the same cardiac cushion mesenchymal cells for proper cardiac valve formation.
Competence in Intelligence Testing: A Training Model for Postgraduate Psychology Students
Authors: Gilmore Linda , Campbell Marilyn 
Published: February 2017

AbstractThe assessment of intellectual ability is a core competency in psychology. The results of intelligence tests have many potential implications and are used frequently as the basis for decisions about educational placements, eligibility for various services, and admission to specific groups. Given the importance of intelligence test scores, accurate test administration and scoring are essential; yet there is evidence of unacceptably high rates of examiner error. This article discusses competency and postgraduate training in intelligence testing and presents a training model for postgraduate psychology students. The model aims to achieve high levels of competency in intelligence testing through a structured method of training, practice and feedback that incorporates peer support, self-reflection and multiple methods for evaluating competency.
Lounais-Suomen metsäkeskuksen alueen metsävarat ja niiden kehitys 1964–98
Authors: Korhonen Kari , Tomppo Erkki , Henttonen Helena , Ihalainen Antti , Tonteri Tiina 
Published: February 2017

Tässä julkaisussa esitetään valtakunnan metsien yhdeksänteen inventointiin (VMI9) perustuvat Lounais-Suomen metsäkeskuksen alueen metsävaratiedot ja niiden muutokset 1966–1998 sekä analysoidaan muutosten syitä. Lisäksi artikkelissa kuvataan yleispiirteet otantamenetelmästä. Inventoinnin otantamenetelmää, maastomittauksia ja tuloslaskentaa kehitettiin yhdeksättä inventointia varten. Menetelmä on kuvattu Etelä-Pohjanmaan tulosjulkaisun yhteydessä (Metsätieteen aikakauskirja 2B/1998). Lounais-Suomen metsäkeskuksen alue muuttui vuonna 1996 ja edelleen vuoden 1999 alussa, minkä vuoksi tähän julkaisuun laskettiin uudelleen nykyisen alueen tulokset viidennestä inventoinnista lähtien. Lounais-Suomen alue poikkeaa maankäytöltään muusta Suomesta, metsätalouden maan osuus on pienin koko maassa (64 % maa-alasta). Erityisesti etelässä on viljelysmaiden osuus maa-alasta suuri. Silti metsätaloudella on tärkeä merkitys alueen elinkeinoelämälle. Metsäteollisuuden lisääntymien alueella lisää metsätalouden merkitystä.
María Teresa Andruetto: «soy descendiente de italianos, soy mujer, soy latinoamericana, soy del interior, soy de provincia...»
Authors: Ansó Valeria 
Published: February 2017

Entrevista realizada por Valeria Ansó María Teresa Andruetto es actualmente una de las escritoras argentinas más estudiadas en el ámbito académico italiano en relación a la literatura de migración y los estudios de género. En esta entrevista indagamos acerca de la relación de la autora con la literatura italiana y con su ascendencia de inmigrantes, así como sus ideas sobre la escritura femenina y su experiencia como escritora proveniente del interior del país que, sin embargo, ingresó al circuito editorial italiano.
Impact of Mild Hypohydration on Muscle Endurance, Power, and Strength in Healthy, Active Older Men
Authors: Goulet Eric D.B. , Mélançon Michel O. , Lafrenière David , Paquin Jasmine , Maltais Mathieu , Morais José A. 
Published: February 2017

Abstract
Goulet, EDB, Mélançon, MO, Lafrenière, D, Paquin, J, Maltais, M, and Morais, JA. Impact of mild hypohydration on muscle endurance, power, and strength in healthy, active older men. J Strength Cond Res 32(12): 3414–3424, 2018—Under particular circumstances older persons may be vulnerable to developing mild chronic hypohydration. In young adults, hypohydration has been shown to impair muscle endurance, power and strength. Muscle performance declines with aging, a condition known as dynapenia. How hypohydration impacts muscle performance in older persons remains unclear. In this study, we examined this question, believing it may identify a factor exacerbating dynapenia. One-hour after having been passively exposed to heat where either a body mass loss of 1% was induced or euhydration maintained with fluid ingestion, 8 healthy, active older men (age: 68 ± 5 years) completed an exercise testing session where indices of muscle strength (30-second chair stand, grip strength, maximal isometric seated leg-press extension), endurance (seated leg-curl flexion + seated leg-press extension to exhaustion at 60% of 1 repetition maximum), and power (30-second Wingate test) were assessed. Gastrointestinal temperature before exercise testing was not significantly different from that measured before heat exposure with neither hydration regimen. Magnitude-based inferential statistics indicate that from a clinical perspective, the effect of hypohydration on 30-second chair stand (−1.0 ± 4.4%) is possibly harmful, for grip strength (−2.4 ± 4.1%), lower limbs endurance (−7.5 ± 11.2%), and anaerobic power (−3.9 ± 4.3%) likely detrimental, and unclear with respect to maximal isometric lower limb strength. Maintaining adequate hydration in older men is important, since hypohydration of only 1% body mass could impede muscle endurance, power and strength and, consequently, worsen the impact of dynapenia.
Can the Critical Power Model Explain the Increased Peak Velocity/Power During Incremental Test After Concurrent Strength and Endurance Training?
Authors: Denadai Benedito S. , Greco Camila C. 
Published: February 2017

Abstract
Denadai, BS and Greco, CC. Can the critical power model explain the increased peak velocity/power during incremental test after concurrent strength and endurance training? J Strength Cond Res 31(8): 2319–2323, 2017—The highest exercise intensity that can be maintained at the end of a ramp or step incremental test (i.e., velocity or work rate at V̇o
2max − Vpeak/Wpeak) can be used for endurance performance prediction and individualization of aerobic training. The interindividual variability in Vpeak/Wpeak has been attributed to exercise economy, anaerobic capacity, and neuromuscular capability, alongside the major determinant of aerobic capacity. Interestingly, findings after concurrent strength and endurance training performed by endurance athletes have challenged the actual contribution of these variables. The critical power model usually derived from the performance of constant-work rate exercise can also explain tolerance to a ramp incremental exercise so that, Vpeak/Wpeak can be predicted accurately. However, there is not yet discussion of possible concomitant improvements in the parameters of the critical power model and Vpeak/Wpeak after concurrent training and whether they can be associated with and therefore depend on different neuromuscular adaptations. Therefore, this brief review presents some evidence that the critical power model could explain the improvement of Vpeak/Wpeak and should be used to monitor aerobic performance enhancement after different concurrent strength- and endurance-training designs.
Hibridador/a
Authors: Negre Marta , Viladomiu Àngels 
Published: February 2017

Les imatges que apareixen en les següents pàgines visuals han sorgit del procés de producció del cartell de Sant Jordi, encarregat per la Universitat de Barcelona.Fitxa tècnica: Obra sobre paper, impressó digital, 3 pàgines de 297 x 420 cm c/u.
Study of price variation among the different brands of anti-tubercular drugs available in India
Authors: P. R. Shreenivas , Prasad S. Nagaraja 
Published: February 2017

Background: India is one of the largest Tuberculosis (TB) burden countries in the world. Although Revised National Tuberculosis Control Programme provides free cost of therapy, sometimes patient get treated by private practioners. This can sometimes lead to irregular course of treatment due to decreased patient compliance. This in turn may lead to multi drug resistance among TB bacilli. One of the reasons for decreased patient compliance is cost of therapy. The present study was undertaken to evaluate the cost of therapy of various anti-TB drugs and their combinations available in India.Methods: The maximum and minimum cost in rupees (INR) of all anti-TB drugs manufactured by various pharmaceutical companies was noted. The cost of 10 tablets/capsules or their fixed dose combinations (FDCs) was calculated. The cost ratio and percentage price variation were calculated for each brand and compared.Results: Percentage variation in cost of oral anti-TB drugs marketed in India was highest in ethambutol 400mg (474.51), cycloserine 250mg (384.61), ethambutol 800mg (321.84) and rifampin 450mg (258.45). The lowest percentage cost variation was seen with pyrazinamide 225mg (10.04), ethambutol 1000mg (18.82) and rifampin 100mg (22.78). Among the FDCs lowest percentage cost variation seen with rifampin 150mg +isoniazid 75mg+pyrazinamide 400mg (0.16) and highest percentage cost variation is seen with rifampin 450mg+isoniazid 300mg+pyrazinamide 750mg+ethambutol 800mg (232.73).Conclusions: There is a significant variation in the cost of different brands of oral anti-TB drugs and their FDCs available in India. The National Pharmaceutical Pricing Authority (NPPA) should take more proactive steps for bringing down the prices of first line anti-TB drugs and the clinicians prescribing them should be aware of the price variation among the various brands of anti-TB drugs available in India.
Areca catechu nut: a double-edged sword
Authors: Sharma Ajitha 
Published: February 2017

The chewing of Areca catechu nut, more popularly known as betel nut, is one of the ancient traditions in India and other South-east Asian countries. Other than its role played in religious practices and cultural rituals, areca nut has also been described to have various health benefits, particularly antihelminthic and antiviral properties, in the traditional systems of medicine like Ayurveda. It was observed to produce an antidepressant-like effect by elevating the serotonin and norepinephrine levels in hippocampus of rats. It also exhibited analgesic and anti-inflammatory activities in mice, and displayed in vitro antioxidant activity. Furthermore, it was found to improve spatial memory and learning behaviour in rats.
Capacity Assessment and Information Provision for Voluntary Psychiatric Patients: a service evaluation in a UK NHS Trust
Authors: Perry Benjamin Ian , Singh Swaran Preet , White David Hedley 
Published: February 2017

Since the Cheshire West judgement, yearly applications for the Mental Health Act (MHA) and Deprivation of Liberty Safeguards (DoLS) have increased, though many patients are still admitted informally. To ensure lawfulness, informal admissions must be capacitous, informed, and without coercion. If fully capacitous consent is not obtained, then there is a risk of “de facto” detention and deprivation of liberty. Deprivation of liberty is only lawful through appropriate legal frameworks (DoLS for incapacitous, non-objecting hospital inpatients, or MHA otherwise). Use of such legal frameworks might be hampered by the perceived stigma associated with them, though this may not be in the best interests of the patient.We aimed to examine the assessment of capacity and provision of adequate information required for an informed voluntary psychiatric admission, and any evidence of possible coercion into informal admission. We postulate variable use of legal frameworks designed to empower patients and prevent illegal deprivation of liberty.
Relationship Between Method and Duration of Contraception Usage to Subjective Health Complaints
Authors: Kusuma Nabella 
Published: February 2017

Subjective health complaints is identified is symptoms and uncomfortable feeling felt by the respondents. Health Complaint is the most common cause of acceptor stops using contraception. The aim of this study was to exsamine between of subjective health complaints related by contraception method and duration of contraception usage. This study was observational analytic with cross sectional design. The sample of study were acceptor living at RW 6 Kalitengah Sidoarjo district and using simple random sampling technique to collect the data. Statistical test using chi square to determine the relationship between variables. The study showed that most of the respondents were aged > 35 years old (62,5%), educated as high as high school (59,7%), were housewife (70,8%). Statistic test using chi square showed that there was relationship between contraception method (p = 0.0098) and the duration of contraception usage (p = 0.012) with subjective health complaints. Hormonal contraceptive methods may increase the risk of 4,05 times to experience subjective health complaints compared with respondents who use non-hormonal contraception. Respondents with long ≤ 5 years of contraceptive use may increase the risk of 7,82 times to experience subjective health complaints compared with respondents who used the contraceptive for > 5 years. It is concluded that contraception method and the duration of contraception usage are related to subjective health complaints. It is recommended for the midwives to educate respondents who were using hormonal contraception to change into using non hormonal contraception when have complaint.Keywords: contraception method, usage duration, subjective health complaints
PENGARUH MARKETING MIX DAN SYARIAH COMPLIANCE TERHADAP KEPUTUSAN NASABAH MEMILIH BANK UMUM SYARIAH DI KUDUS
Authors: Zamroni Zamroni , Rokhman Wahibur 
Published: February 2017

<p><em>This study aimed to examine the influence of mix marketing and sharia compliance on customer’s decision in choosing Sharia bank in Kudus. It used purposive sampling method with 120 respondents. Hypothesis testing used multiple linear regression analysis. The analysis of T test showed that product influences the customer’s decision because thitung &gt; ttable (2,239&gt; 1,</em></p><p><em>657), Price influences the customer’s decision because tcount &gt; ttable (2,563&gt; 1, 657). Place influences the customer’s decision because tcount &gt; ttable (2,002&gt; 1, 657). Promotion influences the customer’s decision because tcount &gt; ttable (4.436&gt; 1,</em></p><p><em>657). Syariah compliance influences the customer’s decision because tcount &gt; ttable (2,072&gt; 1, 657). Based on F test, it indicated that Fcount &gt; Ftable (11 689&gt; 2.290) which means the mix marketing consists of product, price, place, promotion and Sharia compliance significantly influenced the customers’ decision in choosing sharia banks in Kudus.</em></p>
Analisis Fungsi Produksi Usahatani untuk Menunjang Pengembangan Daerah Aliran Sungai Cimanuk
Authors: Pakpahan Agus 
Published: February 2017

<p><strong>Abstrak</strong></p><p> </p><p>Sekitar 43 persen dari total luas DAS Cimanuk telah dijadikan lahan sawah. Hampir 50 persen sawah tersebut berada pada selang ketinggian 0-50 meter dari muka laut, atau dapat juga dikatakan berada di DAS Cimanuk bagian hilir. Dari sawah seluas itu, 48.8 persen dapat diairi dua kali setahun, 41.6 persen satu kali setahun dan 9.6 persen tadah hujan (Dent <em>et al, </em>1977). Dalam pada itu, jumlah dan pertumbuhan penduduk yang tinggi dan keterbatasan lahan pertanian telah menyebabkan nisbah lahan pertanian-orang sangat rendah. Selain langka dalam arti kuantitas, kelangkaan lahan di DAS Cimanuk terjadi pula dalam segi kualitas, yang tergambar dalam kemampuan lahan. Di DAS ini, lahan yang terluas adalah Kelas Kemampuan Lahan (KKL) III, IV, dan V, masing-masing seluas 25 persen, 30 persen dan 13 persen dari total area. KKL I tidak dijumpai dan KKL II hanya 0.04 persen dari total area. Total luas DAS Cimanuk adalah 400 705 ha. Dilatarbelakangi oleh keadaan itu, maka pertanyaan yang timbul adalah faktor-faktor apa saja yang strategis untuk ditangani agar dalam keterbatasan tersebut produksi pangan masih tetap dapat ditingkatkan guna mencukupi kebutuhan pangan penduduk. Dalam menganalisa pertanyaan di atas digunakan tiga bentuk hubungan fungsi: (1) fungsi pangkat, (2) fungsi transcendental dan (3) fungsi inversi log-log. Data yang dianalisa terbagi dalam empat golongan: (1) DAS Cimanuk Agregat, (2) KKL III, (3) KKL IV dan (4) KKL V. Pembandingan Nilai Produk Marginal dengan Nilai Korbanan Marginal digunakan untuk menguji tingkat alokasi masukan. Dari hasil penelitian ini diperoleh informasi bahwa model yang sesuai adalah model transcendental, dan masukan usahatani yang memberikan respon terpenting adalab: luas lahan garapan dan setelah itu pupuk anorganik. Jumlah penggunaan tenaga kerja sudah harus dikurangi. Pada KKL yang berbeda respon luas maupun pupuk berbeda pula. Pada KKL III, KKL IV, dan KKL V besaran respon luas garap pada masing-masing KKL tersebut adalah: 0.75, 0.53 dan 0.24; sedangkan respon pupuk anorganik pada masing-masing KKL tersebut adalah: 0.20, 0.16 dan 0.04. Selanjutnya, hasil pembandingan Nilai Produk Marginal dengan Biaya Korbanan Marginal menunjukkan bahwa usahatani sawah pada KKL V adalah tidak efisien, sedangkan pada KKL III dan IV penggunaan masukan masih perlu dikembangkan agar mencapai tingkat optimal, kecuali untuk masukan tenaga kerja. Untuk dapat menangkap respon dari luas garapan yang cukup tinggi mungkin dapat dilakukan melalui peningkatan intensitas tanam. Hal tersebut dapat dilakukan apabila sistim irigasi yang tersedia memadai. Sedangkan untuk mengamankan irigasi dan melestarikan sumberdaya lahan dan air maka investasi dalam bidang konservasi sumberdaya lahan/tanah dan air di DAS Cimanuk bagian hulu sangat diperlukan.</p>
Produktivitas dan Efisiensi Teknis Usahatani Padi Organik Lahan Sawah
Authors: Prayoga Adi 
Published: February 2017

<strong>ABSTRAK</strong><br /><br />Penelitian produktivitas dan efisiensi teknis usahatani padi organik lahan sawah dilakukan di Desa Sukorejo dan Jambeyan, Kecamatan Sambirejo, Kabupaten Sragen menggunakan responden sebanyak 120 orang yang dipilih dengan teknik non proportionate stratified random sampling yang terbagi sama besar dalam empat strata. Penelitian ini bertujuan untuk menganalisis produktivitas, efisiensi teknis dan sumber inefisiensi teknis padi organik, serta membandingkan dengan padi konvensional. Produktivitas diukur dengan pendekatan produktivitas faktor total menggunakan angka indeks TFP. Efisiensi teknis diukur dengan menggunakan fungsi produksi frontier yang diestimasi dengan metode MLE, dengan mengasumsikan Cobb-Douglas adalah bentuk fungsional usahatani padi organik di daerah penelitian. Estimasi sumber inefisiensi teknis menggunakan model regresi linier yang diestimasi secara simultan dengan fungsi produksi frontier. Hasil Penelitian menunjukkan bahwa petani padi organik tahun ke-8 dan tahun ke-5 lebih produktif dibandingkan petani padi konvensional. Tingkat efisiensi teknis yang dicapai petani sampel bervariasi antara 0,47 – 0,96 dengan rata-rata 0,70. Tingkat efisiensi teknis petani padi organik tahun ke-8 dan tahun ke-5 lebih tinggi secara signifikan dibandingkan petani padi konvensional. Hasil penelitian juga menemukan bahwa jumlah anggota keluarga usia produktif dan frekuensi mengikuti kegiatan penyuluhan berpengaruh menurunkan inefisiensi teknis.
A Study Of Farm-Level Input Demands Without Seed Selectivity Adjustment on Rice Farms in The Cimanuk River Basin, Jawa Barat
Authors: Hutabarat Budiman 
Published: February 2017

<p><strong>Abstract</strong></p><p><br />This paper is an attempt to analyze how a rice farmer responds to economic stimulus through allocating his resources reflected in elasticities of input demands. Specifically, in the model seed selectivity adjustment is not taken into account, that is, modern and traditional variety farmer elasticities are separately computed and then compared. The sample farmers were drawn from six desas in the area of the Cimanuk River Basin, Jawa Barat, which has been and still is currently dominated by rice farming. The results show that the own-price elasticities of demand for nitrogen fertilizer of TV (traditional variety) farmers are higher than that of MV (modern variety) farmers. These elasticities tend to decline overtime.</p>