bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids
Authors: Carroll Thomas D. , Langlands Alistair J. , Osborne James M. , Newton Ian P. , Appleton Paul L. , Näthke Inke 
Published: October 2017

ABSTRACT
Homeostasis of renewing tissues requires balanced proliferation, differentiation and movement. This is particularly important in the intestinal epithelium where lineage tracing suggests that stochastic differentiation choices are intricately coupled to the position of a cell relative to a niche. To determine how position is achieved, we followed proliferating cells in intestinal organoids and discovered that the behaviour of mitotic sisters predicted long-term positioning. We found that, normally, 70% of sisters remain neighbours, while 30% lose contact and separate after cytokinesis. These post-mitotic placements predict longer term differences in positions assumed by sisters: adjacent sisters reach similar positions over time; in a pair of separating sisters, one remains close to its birthplace while the other is displaced upward. Computationally modelling crypt dynamics confirmed that post-mitotic separation leads to sisters reaching different compartments. We show that interkinetic nuclear migration, cell size and asymmetric tethering by a process extending from the basal side of cells contribute to separations. These processes are altered in adenomatous polyposis coli (Apc) mutant epithelia where separation is lost. We conclude that post-mitotic placement contributes to stochastic niche exit and, when defective, supports the clonal expansion of Apc mutant cells.
Non-invasive evaluation of stable renal allograft function using point shear-wave elastography
Authors: Kim Bom Jun , Kim Chan Kyo , Park Jung Jae 
Published: October 2017

Objective:
To investigate the feasibility of point shear-wave elastography (SWE) in evaluating patients with stable renal allograft function who underwent protocol biopsies.

Methods:
95 patients with stable renal allograft function that underwent ultrasound-guided biopsies at predefined time points (10 days or 1 year after transplantation) were enrolled. Ultrasound and point SWE examinations were performed immediately before protocol biopsies. Patients were categorized into two groups: subclinical rejection (SCR) and non-SCR. Tissue elasticity (kPa) on SWE was measured in the cortex of all renal allografts.

Results:
SCR was pathologically confirmed in 34 patients. Tissue elasticity of the SCR group (31.0 kPa) was significantly greater than that of the non-SCR group (24.5 kPa) (=0.016), while resistive index value did not show a significant difference between the two groups (p = 0.112). Tissue elasticity in renal allografts demonstrated significantly moderate negative correlation with estimated glomerular filtration rate (correlation coefficient = −0.604, p &lt; 0.001). Tissue elasticity was not independent factor for SCR prediction on multivariate analysis.

Conclusion:
As a non-invasive tool, point SWE appears feasible in distinguishing between patients with SCR and without SCR in stable functioning renal allografts. Moreover, it may demonstrate the functional state of renal allografts.

Advances in knowledge:
On point SWE, SCR has greater tissue elasticity than non-SCR.
Uncertainty Propagation from the Cell Transmission Traffic Flow Model to Emission Predictions: A Data-Driven Approach
Authors: Sayegh Arwa S. , Connors Richard D. , Tate James E. 
Published: October 2017

Road traffic exhaust emission predictions are used to inform transport policy and investment decisions aimed at reducing emissions and achieving sustainable mobility. Emission predictions are also used as inputs when modeling air quality and human exposure to traffic-related air pollutants. To be effective, such policies and/or integration must be based on robust models that not only provide point-based predictions but also inform these with an interval of confidence that properly accounts for the propagation of uncertainties through the complex chain of models involved. This paper develops a data-driven methodological framework that enables calculating the uncertainty in average speed–based emission predictions induced by uncertainty in its traffic data inputs, which are most often predictions (or outputs) of traffic flow models. An ensemble-based optimisation approach is used to estimate both calibration and validation errors arising from uncertainty in the structure and parameterisation of the cell transmission model, a discretised first-order macroscopic traffic flow model that is often integrated with average speed–based emission models. A Monte Carlo sampling approach is proposed to propagate the uncertainty in traffic flow inputs to emission predictions. To ensure transferability of findings, this methodology has been tested using multiple real data sets on three motorway road networks, one of which operates under variable speed limits. The online appendix is available at https://doi.org/10.1287/trsc.2017.0787 .
Production of highly nutritious functional food with the supplementation of wheat flour with lysine
Authors: Albert Cs. , Gombos S. , Salamon R. V. , Csiki Z. , Prokisch J. , Csapó J. 
Published: October 2017

Abstract
During our research, we added 0.5–2.0% L-lysine to wheat flour in order to increase the quantity of this essential amino acid and the biological value of the wheat protein, producing such a functional, health-protecting, and health-preserving foodstuff that is suitable for satisfying the lysine requirement of humans, assuming normal nutrition. Furthermore, by the increase of the biological value completing the wheat flour with a higher amount of lysine, we could produce such a functional, health-protecting and health-preserving food that is suitable for containing or preventing lysine malnutrition symptoms. During our work, we determined the quantity of the Maillard reaction products (hydroxymethyl-furfural) and the lysine content developed during the baking of the wheat flour used for bread baking and in the bread baked with supplemented or without supplemented lysine, and evaluated the sensory characteristics of the produced functional food and the bread supplemented with lysine.
Effects of pectolytic enzyme treatment and microfiltration on antioxidant components of elderberry juice
Authors: Furulyás D. , Nyéki F. , Stéger-Máté M. , Stefanovits-Bányai É. , Bánvölgyi Sz. 
Published: October 2017

AbstractIn this study, pectolytic enzymes (Pectinex BE XXL,Trenolin Rot, andFructozym P) were investigated for their influence on phenolic, anthocyanin content, and antioxidant activities of elderberry (Sambucus nigraL.) pulps during juice processing. Prior to pressing the berries, three different enzymes were added to pulps in order to evaluate the effect of different pectolytic enzyme treatments on the valuable components of elderberry juice. Control sample was prepared without enzyme. After treatment, squeezing, and clarification steps, microfiltration was carried out with ceramic membrane. The effect of this technology on the antioxidant capacity, total polyphenol content, and total anthocyanin content of the clarified elderberry juices has been evaluated in permeate and retentate samples, and membrane retention was calculated. Significantly lower antioxidant capacity was detected in the case of control sample than that obtained using enzyme-treated juices. Retention of antioxidant content on the microfiltration membrane was greatly reduced by using the enzymes. Higher valuable component yield was obtained usingFructozym Penzyme compared withPectinex BE XXLused in industry.
The role of vitamins in the diet of the elderly II. Water-soluble vitamins
Authors: Csapó J. , Albert Cs. , Prokisch J. 
Published: October 2017

Abstract
Following a presentation of humans’ water-soluble vitamin requirements, the authors will discuss in detail the role these vitamins play in human organism and outline those major biochemical processes that are negatively affected in the body in case of vitamin deficiency. They point out that in the elderly population of developed countries cases of water-soluble vitamin deficiency are extremely rare and they are due to the lack of dietary vitamin, but mostly to the vitamin being released from its bindings, the difficulty of free vitamin absorption, gastrointestinal problems, medication, and often alcoholism. Among water-soluble vitamins, B12 is the only one with a sufficient storage level in the body, capable of preventing deficiency symptoms for a long period of time in cases of vitamin-deficient nutrition. Each type of vitamin is dealt with separately in discussing the beneficial outcomes of their overconsumption regarding health, while the authors of the article also present cases with contradictory results. Daily requirements are set forth for every water-soluble vitamin and information is provided on the types of nutrients that help us to the water-soluble vitamins essential for the organism.
Cell-based in vitro models in environmental toxicology: a review
Authors: Poteser Michael 
Published: October 2017

AbstractAn analysis of biological effects induced by environmental toxins and exposure-related evaluation of potential risks for health and environment represent central tasks in classical biomonitoring. While epidemiological data and population surveys are clearly the methodological frontline of this scientific field, cellbased in vitro assays provide information on toxin-affected cellular pathways and mechanisms, and are important sources for the identification of relevant biomarkers. This review provides an overview on currently available in vitro methods based on cultured cells, as well as some limitations and considerations that are of specific interest in the context of environmental toxicology. Today, a large number of different endpoints can be determined to pinpoint basal and specific toxicological cellular effects. Technological progress and increasingly refined protocols are extending the possibilities of cell-based in vitro assays in environmental toxicology and promoting their increasingly important role in biomonitoring.
Speaking assessment perceptions and practices of English teachers at tertiary level in the Turkish context
Authors: Özdemir-Yılmazer Meryem , Özkan Yonca 
Published: October 2017

AbstractTeaching speaking is one of the challenging dimensions of teaching English as a foreign language. In the Turkish educational setting, students are exposed to English from second grade at the primary level until the first grade at tertiary level. Although the exposure to English is intensive, it is observed that students are unable to solve language-related problems even at tertiary level. A recent British Council report (2015) revealed that students recruited at Turkish universities have an inadequate level of speaking proficiency relative to the standards of the Common European Framework of Reference (CEFR). The reason may be multi-faceted; however, investigation of assessment practices of English instructors may shed light on this problem. This study aims to investigate tertiary-level English language teachers’ perceptions and practices of speaking assessment. Personal Construct Theory (PCT) forms the basis for this case study. The data was collected via repertory grids, semi-structured interviews, and classroom observation. Focus grid analysis was conducted to analyze and interpret the data. The findings of the study reveal that the participants do have individualized beliefs regarding assessment of speaking, which necessitates training for teachers on classroom assessment to raise their awareness regarding commonality of practice in in-class speaking assessment.
A Generally Efficient Targeted Minimum Loss Based Estimator based on the Highly Adaptive Lasso
Authors: van der Laan Mark 
Published: October 2017

AbstractSuppose we observe$n$independent and identically distributed observations of a finite dimensional bounded random variable. This article is concerned with the construction of an efficient targeted minimum loss-based estimator (TMLE) of a pathwise differentiable target parameter of the data distribution based on a realistic statistical model. The only smoothness condition we will enforce on the statistical model is that the nuisance parameters of the data distribution that are needed to evaluate the canonical gradient of the pathwise derivative of the target parameter are multivariate real valued cadlag functions (right-continuous and left-hand limits, (G. Neuhaus. On weak convergence of stochastic processes with multidimensional time parameter. Ann Stat 1971;42:1285–1295.) and have a finite supremum and (sectional) variation norm. Each nuisance parameter is defined as a minimizer of the expectation of a loss function over over all functions it its parameter space. For each nuisance parameter, we propose a new minimum loss based estimator that minimizes the loss-specific empirical risk over the functions in its parameter space under the additional constraint that the variation norm of the function is bounded by a set constant. The constant is selected with cross-validation. We show such an MLE can be represented as the minimizer of the empirical risk over linear combinations of indicator basis functions under the constraint that the sum of the absolute value of the coefficients is bounded by the constant: i.e., the variation norm corresponds with this$L_1$-norm of the vector of coefficients. We will refer to this estimator as the highly adaptive Lasso (HAL)-estimator. We prove that for all models the HAL-estimator converges to the true nuisance parameter value at a rate that is faster than$n^{-1/4}$w.r.t. square-root of the loss-based dissimilarity. We also show that if this HAL-estimator is included in the library of an ensemble super-learner, then the super-learner will at minimal achieve the rate of convergence of the HAL, but, by previous results, it will actually be asymptotically equivalent with the oracle (i.e., in some sense best) estimator in the library. Subsequently, we establish that a one-step TMLE using such a super-learner as initial estimator for each of the nuisance parameters is asymptotically efficient at any data generating distribution in the model, under weak structural conditions on the target parameter mapping and model and a strong positivity assumption (e.g., the canonical gradient is uniformly bounded). We demonstrate our general theorem by constructing such a one-step TMLE of the average causal effect in a nonparametric model, and establishing that it is asymptotically efficient.
Crystal structure of 1-(carboxymethyl)-1H-benzo[d][1,2,3]triazole 3-oxide, C8H7N3O3
Authors: Yu Minxia 
Published: October 2017

Abstract
C8H7N3O3, monoclinic, P21/c (no. 14), a = 7.2526(12) Å, b = 10.0770(18) Å, c = 11.906(2) Å, β = 104.393(3)°, V = 842.8(2) Å3, Z = 4, R
gt(F) = 0.0375, wR
ref(F
2) = 0.0766, T = 293 K.
A new geometrical model for mixing of highly viscous fluids by combining two-blade and helical screw agitators
Authors: Hadjeb Abdessalam , Bouzit Mohamed , Kamla Youcef , Ameur Houari 
Published: October 2017

Abstract
Mixing processes are becoming today a huge concern for industrialists in various domains like the pharmaceutical production, oil refining, food industry and manufacture of cosmetic products especially when the processes are related to the mixing of highly viscous products. So the choice of a stirring system for this category of products or fluids must be rigorously examined before use because of the flows which are laminar in the most cases, something that is not good to obtain homogeneous particles or suspensions after the mixing operation. This CFD study allows developing a new geometrical model of mechanical agitator with high performance for mixing of highly viscous fluids. It consists of a combination of two bladed and helical screw agitators. The investigations of the flow structure generated in the vessel are made by using the computer code ANSYS CFX (version 13.0), which allows us to realize and test the effectiveness of the new stirrer on the resulting mixture and power consumption.
Equilibrium and kinetics studies for the adsorption of Ni2+ and Fe3+ ions from aqueous solution by graphene oxide
Authors: Konicki Wojciech , Aleksandrzak Małgorzata , Mijowska Ewa 
Published: October 2017

Abstract
In this study, the adsorption of Ni2+ and Fe3+ metal ions from aqueous solutions onto graphene oxide (GO) have been explored. The effects of various experimental factors such as pH of the solution, initial metal ion concentration and temperature were evaluated. The kinetic, equilibrium and thermodynamic studies were also investigated. The adsorption rate data were analyzed using the pseudo-first-order kinetic model, the pseudo-second-order kinetic model and the intraparticle diffusion model. Kinetic studies indicate that the adsorption of both ions follows the pseudo-second-order kinetics. The isotherms of adsorption data were analyzed by adsorption isotherm models such as Langmuir and Freundlich. Equilibrium data fitted well with the Langmuir model. The maximum adsorption capacities of Ni2+ and Fe3+ onto GO were 35.6 and 27.3 mg g−1, respectively. In addition, various thermodynamic parameters, such as enthalpy (ΔHO), entropy (ΔSO) and Gibbs free energy (ΔGO), were calculated.
Ana Laura Lanteri (coordinadora). 2013. Actores e identidades en la construcción del Estado Nacional (Argentina, siglo XIX) . Buenos Aires: Teseo. ISBN 978-987-1867-63-9
Authors: Piazzi Dietz Carolina Andrea 
Published: October 2017

Esta obra es fruto de la producción del Grupo de Investigación Problemas y Debates del Siglo XIX, radicado en la Universidad Nacional de Mar del Plata (Argentina) y dirigido por la Dra. Valentina Ayrolo. Puede pensarse como una segunda contribución, en formato libro, luego de la aparición de otra compilación realizada por Valentina Ayrolo (2010)
Design Elements Affecting the Using of Atriums in Shopping Malls in Erbil city
Authors: Ali Lana , Ali Ansam , Muhammad Shna 
Published: October 2017

Open space represent one of the most important aspects of urban environment which affects our life each single day and usually people have a good relation with them, and as there are an outdoor open spaces there are also inner ones that usually people involve with it most of time, Atriums represents one of these spaces which consider large covered central courtyard acts as an attraction area where humans interact & communicate with each other as gathering place ,relaxing ,galleries and exhibitions.
Shopping malls owns such spaces which acts effectively when it described in two ideas; business success and architectural success. The research will focus on the architectural success by specifying the occupational efficiency of atriums, although previous literatures covered many architectural aspects of these atriums but, the research noticed weakness in the relation between architectural design factors and users in atrium, regarding physical factors and occupational efficiency which declare as a density of using atriums in Malls that have been explained in two parts (Theoretical and Practical).the research focus on analyzing five malls in Erbil city.
Effect of the existence of under drain on Uplift pressure and Exit Gradient.
Authors: Al-Suhili Prof. Dr. Rafa , Hussien Goran 
Published: October 2017

The effects of the existence of an under drain pipe beneath the foundation of a hydraulic structure, on both the uplift pressure under the structure and the exit gradient on its downstream side are investigated. More specifically the effect of the horizontal and vertical locations and the diameter of this under drain pipe were investigated. The Geo-Studio Seep/w software is used for simulating different geometrical configurations of a typical hydraulic structure model. Results indicate that the existence of this drain will reduce the pressure head beneath the foundation of the structure. The observed reduction in uplift pressure is found huge. As the drain diameter increases the pressure head decrease more and more. This results in a required volume against overturning to decrease with using greater diameter which is tend to 100% decrease in (V) especially where the under drain location near u/s sheet pile (location –D-). The exit gradient decrease with using drain pipe near upstream sheet pile but it increase where the drain pipe below downstream sheet pile especially (location-G-) which is downstream length of protection (L) increase from (2.837m for without drain) to (4.70 m with location G) that means about 65.67% increase.
Strengthening of Reinforced Concrete T-Beam with Web Opening.
Authors: Hassan Bedar , Abdul-Kadir Prof. Dr. Mohamed , Ghafoor Dr. Kawan 
Published: October 2017

This study examines shear capacity of strengthened reinforced concrete T-beams with web rectangular opening. Effect of opening orientation, presence of flange, different types of strengthening, and absence of shear reinforcement in strengthened beams are discussed and evaluated. The experimental work consisted of testing 13 beams under single point load. One of them considered as control beam without opening, while others are cast as beams with preplanned 100mm×200mm opening located at the web of the beam horizontally and vertically.
The results of the beams indicated that the beams with horizontal openings show reduction in the ultimate shear capacity by about 17% while for vertical opening the reduction was about 27% compared to the control beam without opening .Moreover, the presence of the flange increased the shear capacity of the beams with horizontal and vertical openings by about 11% and 34.5% respectively. Also, the results indicated that the internal strengthening with inclined stirrups increased ultimate capacity by about 18% and 11% for horizontal and vertical openings compared to control T-beams with web opening respectively. The CFRP strips with spacing between them increased shear capacity by about 13.5% for horizontal opening but was not beneficial for vertical opening, also the CFRP strips for strengthening of opening made after construction were not beneficial for both types of opening and the capacity was decreased by about 11.5% and 10.1% for horizontal and vertical opening respectively. Strengthened beams with CFRP strips without spacing between them strengthened the bottom chord of the opening furthermore and they were best scheme of strengthening beam with vertical opening and increased shear capacity by about 12% for both types of opening.
New fixed point results in partial quasi-metric spaces
Authors: Mohammadi Zahra , Valero Oscar 
Published: October 2017

Abstract
In 1970, D.S. Scott gave applications of Kleene’s fixed point theorem to describe the meaning of recursive denotational specifications in programming languages. Later on, in 1994, S.G. Matthews and, in 1995, M.P. Schellekens gave quantitative counterparts of the Kleene fixed point theorem which allowed to apply partial metric and quasi-metric fixed point techniques to denotational semantics and asymptotic complexity analysis of algorithms in the spirit of Scott. Recently, in 2005, J.J. Nieto and R. Rodríguez-López made an in-depth study of how to reconcile order-theoretic and metric fixed point techniques in the classical metric case with the aim of providing the existence and uniqueness of solutions to first-order differential equations admitting only the existence of a lower solution. Motivated by the aforesaid fixed point results we prove a partial quasi-metric version, when the specialization order is under consideration, of the fixed point results of Nieto and Rodríguez-López in such a way that the results of Matthews and Schellekens can be retrieved as a particular case.