bluuebunny/crossref_metadata_2025_split huggingface dataset:
Protein sites with more coevolutionary connections tend to evolve slower, while more variable protein families acquire higher coevolutionary connections
Authors: Mandloi Sapan , Chakrabarti Saikat 
Published: July 2017

Background: Amino acid exchanges within proteins sometimes compensate for one another and could therefore be co-evolved. It is essential to investigate the intricate relationship between the extent of coevolution and the evolutionary variability exerted at individual protein sites, as well as the whole protein. Methods: In this study, we have used a reliable set of coevolutionary connections (sites within 10Å spatial distance) and investigated their correlation with the evolutionary diversity within the respective protein sites. Results: Based on our observations, we propose an interesting hypothesis that higher numbers of coevolutionary connections are associated with lesser evolutionary variable protein sites, while higher numbers of the coevolutionary connections can be observed for a protein family that has higher evolutionary variability. Our findings also indicate that highly coevolved sites located in a solvent accessible state tend to be less evolutionary variable. This relationship reverts at the whole protein level where cytoplasmic and extracellular proteins show moderately higher anti-correlation between the number of coevolutionary connections and the average evolutionary conservation of the whole protein. Conclusions: Observations and hypothesis presented in this study provide intriguing insights towards understanding the critical relationship between coevolutionary and evolutionary changes observed within proteins. Our observations encourage further investigation to find out the reasons behind subtle variations in the relationship between coevolutionary connectivity and evolutionary diversity for proteins located at various cellular localizations and/or involved in different molecular-biological functions.
Pension Obligations in the European Union: A Case Study for Accounting Policy
Authors: Biondi Yuri , Boisseau-Sierra Marion 
Published: July 2017

AbstractPension obligations constitute a critical issue for public finances and budgets. This is especially true for the European Union whose institutional mechanism aims to supervise Member States’ spending through centralised budgetary rules based upon financial covenants. In this context, accounting methods of recognition and measurement of pension obligations become an integral and critical aspect of Europe’s transnational budgetary and financial supervision. Drawing upon a comprehensive overview of pension management and regulation, this article aims to analyse the ongoing debate on accounting for pension obligations with a specific attention to the harmonization of European Public Sector Accounting Standards (EPSAS). While the European Commission has been favouring the ‘indisputable reference’ to the International Public Sector Accounting Standards (IPSAS), European Member States’ practices and views remain inconsistent with the normative solution imposed by the IPSAS 25, which favours and facilitates Definite Contribution pension schemes. In this context, we do summarise the IPSAS position mimicking the IFRS, review the pension’s accounting in national statistics and EPSAS debate, and provide some building blocks for a comprehensive model of accounting for pension obligations that admits and enables several viable modes of pension management.
MiR-107 inhibits proliferation of lung cancer cells through regulating TP53 regulated inhibitor of apoptosis 1 (TRIAP1)
Authors: Wang Bing , Zuo Zhanjie , Lv Fang , Zhao Liang , Du Minjun , Gao Yushun 
Published: July 2017

AbstractAimsAccumulating evidence indicates that aberrant expression of miR-107 plays a crucial role in cancers. This study aims to display the function of miR-107 and its novel target genes in the progression of lung cancer.Methods and MaterialMiR-107 or miR-107 inhibitor was transfected into lung cancer cells A549. The levels of miR-107 and TP53 regulated inhibition of apoptosis 1 (TRIAP1) were examined by quantitative real-time Polymerase Chain Reaction (qRT-PCR) analysis and Western Blot. Functionally, MTT and colony formation assays were carried out to test the effect of miR-107 inhibitor and/or small interference RNA (siRNA) targeting TRIAP1 mRNA on proliferation of lung cancer cells. Levels of miR-107 or TRIAP1 were detected in clinical lung cancer samples by using qRT-PCR analysis.ResultsQRT-PCR analysis revealed that miR-107 inhibitor or miR-107 was successfully transfected into A549 cells. Western Blot indicated that miR-107 decreased the expression of TRIAP1 protein in the cells. In contrast, miR-107 inhibitor augmented the levels of TRIAP1 protein. Functionally, miR-107 inhibitor remarkably suppressed A549 cell proliferation, whereas, TRIAP1 siRNAs could abrogate the miR-107 inhibitor-induced proliferation of cells. Then, we validated that TRIAP1 was increased in clinical lung cancer samples. MiR-107 expression was negatively related to TRIAP1 expression in clinical lung cancer samples.ConclusionsMiR-107 suppresses cell proliferation by targeting TRIAP1 in lung cancer. Our finding allows new insights into the mechanisms of lung cancer that is mediated by miR-107.
Environmental Geochemistry of Geophagic Materials from Free State Province in South Africa
Authors: Ekosse Georges-Ivo E. , Ngole-Jeme Veronica M. , Diko Makia L. 
Published: July 2017

AbstractNine geophagic material samples were analysed in order to characterise their mineralogical and elemental constituents, and infer on their health threats. Most abundant mineral in the samples was quartz, followed by smectite, kaolinite and muscovite in minor; and microcline, plagioclase, and goethite in trace quantities. Dominant major oxides were SiO
Mapping Mangrove Density from Rapideye Data in Central America
Authors: Son Nguyen-Thanh , Chen Chi-Farn , Chen Cheng-Ru 
Published: July 2017

AbstractMangrove forests provide a wide range of socioeconomic and ecological services for coastal communities. Extensive aquaculture development of mangrove waters in many developing countries has constantly ignored services of mangrove ecosystems, leading to unintended environmental consequences. Monitoring the current status and distribution of mangrove forests is deemed important for evaluating forest management strategies. This study aims to delineate the density distribution of mangrove forests in the Gulf of Fonseca, Central America with Rapideye data using the support vector machines (SVM). The data collected in 2012 for density classification of mangrove forests were processed based on four different band combination schemes: scheme-1 (bands 1–3, 5 excluding the red-edge band 4), scheme-2 (bands 1–5), scheme-3 (bands 1–3, 5 incorporating with the normalized difference vegetation index, NDVI), and scheme-4 (bands 1–3, 5 incorporating with the normalized difference red-edge index, NDRI). We also hypothesized if the obvious contribution of Rapideye red-edge band could improve the classification results. Three main steps of data processing were employed:
Adolescent suicide as a global public health issue
Authors: Abraham Zebib K. , Sher Leo 
Published: July 2017

Abstract
Youth suicide is a major global mental health problem. This review looks at the epidemiology, risk and protective factors associated with youth suicide, and global strategies to address this important issue. To better understand factors contributing to youth suicide, global gender differences in suicide were examined. Global rates of suicide amongst young men are higher than young women. However, there are anomalously higher rates of female youth suicide in India and China, and possible causes of this are examined further. It is likely that underestimation of youth suicide is a major factor affecting the accuracy of suicide epidemiology. Risk factors for youth suicide are varied. Psychiatric factors include various psychiatric illnesses, substance use (particularly amongst refugee and homeless youth). Psychosocial risk factors include family conflict, physical and sexual childhood abuse, isolation, socioeconomic disadvantage, discrimination and acculturation. Vulnerable populations are at increased risk, including refugee/immigrant/indigenous youth, those in foster care and homeless youth. Protective factors can include family cohesion and strong interpersonal relationships, as well as increased access to care. Global strategies to prevent youth suicide include reducing lethal means to suicide and reducing harmful media reporting. Various psychosocial interventions may be helpful, including individual support, and family, school and community based interventions. Strategies can also increase evaluation of psychiatric disorders and access to care, as well as promote psycho-education and reduce stigma against mental illness.
Multilingualism, urban change and gentrification in the landscape of a Brussels neighbourhood
Authors: Vandenbroucke Mieke 
Published: July 2017

AbstractThis paper focuses on how different historical stages of socio-economic development in Brussels are played out on the ground over time in one particular inner-city neighbourhood, the Quartier Dansaert. In particular, I document the history of this neighbourhood and how urban change and gentrification have impacted the outlook of multilingualism and the development of multilingual discourses and language hierarchies in its material and semiotic landscape over time. By using the rich history of multilingualism in the Quartier Dansaert as a case-study, I argue in favour of more historically-sensitive and longitudinal approaches to social and, in particular, linguistic change as played out in urban landscape.
Transitional Justice in the Middle East and North Africa – Taking Account of Islam
Authors: Yusuf Hakeem O. 
Published: July 2017

AbstractThe core of the argument of this article is that the integration of Islamic notions of justice into transitional justice mechanisms in the MENA makes for a more viable and sustainable transitional justice process in the region. This would mean a critical cultural value in the MENA is given a place in dealing with the past and mapping out a sustainable future in the region. The argument here is premised on the logic that a social transformation-focused enterprise like transitional justice ought to engage with Islam for sustainable outcomes in societies in the MENA where Islam is very influential. Given the significant role and influence of Islam on cultural, socio-political and legal institutions in the MENA, a process of transitional justice that takes account of Islamic values and practices is important for negotiating justice and institutionalising reforms in societies in the region.
A novel mutation in the FOXC2 gene: a heterozygous insertion of adenosine (c.867insA) in a family with lymphoedema of lower limbs without distichiasis
Authors: Planinsek Rucigaj Tanja , Rijavec Matija , Miljkovic Jovan , Selb Julij , Korosec Peter 
Published: July 2017

Abstract

Background
Primary lymphoedema is a rare genetic disorder characterized by swelling of different parts of the body and highly heterogenic clinical presentation. Mutations in several causative genes characterize specific forms of the disease. FOXC2 mutations are associated with lymphoedema of lower extremities, usually distichiasis and late onset.

Patients and methods
Subjects from three generations of a family with lymphoedema of lower limbs without distichiasis were searched for mutations in the FOXC2 gene.

Results
All affected family members with lymphoedema of lower limbs without distichiasis, and still asymptomatic six years old girl from the same family, carried the same previously unreported insertion of adenosine (c.867insA) in FOXC2.

Conclusions
Identification of a novel mutation in the FOXC2 gene in affected family members of three generations with lymphoedema of lower limbs without distichiasis, highlights the high phenotypic variability caused by FOXC2 mutations.
The Selection of Litigation against Government Agencies: Evidence from China
Authors: Cui Wei , Wang Zhiyuan 
Published: July 2017

AbstractWe test the relevance of the selection theory of litigation in a contemporary, civil law setting, using Chinese judicial data that span 25 years regarding lawsuits against government agencies. Civil law systems may be characterized by lower costs of litigation and lower rates of settlement than the U.S. legal system, and therefore the presence of selection effects cannot be assumed. We show that selection effects are indeed manifest in Chinese administrative litigation, and suggest that this may be explained by hidden or intangible litigation costs. Our test for selection effects builds on the approach of previous U.S. studies and potentially allows the identification of selection effects to help improve inferences from decided cases. Finally, we examine patterns of settlement and plaintiff wins in pre-litigation administrative appeals in China, and do not find sufficient evidence for selection effects in this process. This could potentially be explained if most appellants pursuing administrative appeals do not intend to litigate.
Influence of micro- and nanofiller contents on friction and wear behavior of epoxy composites
Authors: Ozsoy Iskender , Mimaroglu Adullah , Unal Huseyin 
Published: July 2017

AbstractIn this study, the influence of micro- and nanofiller contents on the tribological performance of epoxy composites was studied. The fillers are micro-Al2O3, micro-TiO2, and micro-fly ash and nano-Al2O3, nano-TiO2, and nanoclay fillers. The microfillers were added to the epoxy by 10%, 20%, and 30% by weight. The nanofillers were added to the epoxy by 2.5%, 5%, and 10%. Friction and wear tests were conducted using the pin-on-disc arrangement. Tribo elements consisted of polymer pin and DIN 1.2344 steel counterface disc. A load value of 15 N, a sliding speed of 0.4 m/s, a sliding distance of 2000 m, and dry atmospheric conditions were applied to test conditions. The results show that the friction coefficients and the specific wear rates of the nanofilled composites increase as the filler content increases. For microfiller-filled epoxy composites, these values decrease as filler content increases. The tribological performance of epoxy composites is enhanced by the addition of microfillers, and the higher enhancement is reached with the addition of 30% fly ash filler. Finally, the pin and disc worn surface images show the presence of adhesive and some abrasive wear mechanisms.
Numerical study on the interfacial behavior of Mg/Al plate in explosive/impact welding
Authors: Yuan Xiaodan , Wang Wenxian , Cao Xiaoqing , Zhang Tingting , Xie Ruishan , Liu Ruifeng 
Published: July 2017

AbstractIn this study, the process of explosive welding of Mg/Al plate is represented, and the interfacial behavior of two metals is researched. The objective of this work is to investigate the factors that affect the quality of explosive bonding and the distribution of physical parameters on the collision. A finite difference engineering package with smoothed particle hydrodynamics method is used to model the oblique impact of a thin flyer plate (Al) on a relatively thick base plate (Mg). Wavy interface and jetting phenomenon, which existed in the experiment, are well reproduced in the simulation. The contours of pressure, shear stress, velocity, and effective plastic strain of magnesium and aluminum are also distinctly described. The bonding turns out to be a possible solid-state welding process. The effective plastic strain exceeds a minimum value, and the shear stress is just the opposite sign in this simulation where available bonding occurred. Wave formation appears to be the result of variation in the velocity distribution on the interface and periodic disturbances of magnesium and aluminum. A transition from straight to wave occurs along the interface. High values of plastic strain of two metals are predicted on the interface.
El potencial pedagógico de la pragmática sociocultural como herramienta de mediación en la interpretación de experiencias interculturales
Authors: Morollón Martí Natalia 
Published: July 2017

ResumenEl propósito de este trabajo es investigar de qué forma una aproximación sociocultural al estudio de la cortesía puede contribuir a promover la conciencia metapragmática e introducir una dimensión intercultural en el aula universitaria de español como lengua extranjera (ELE). Para ello, esta investigación muestra el análisis de la actividad reflexiva en grupos de estudiantes universitarios. Durante el desarrollo de estas reflexiones, el conocimiento teórico y conceptual relativo al área de investigación de la pragmática sociocultural, presentado en forma de enseñanza explícita, es empleado como herramienta de mediación durante el desarrollo del diálogo colaborativo (Swain, 2006. Languaging, agency and collaboration in advanced second language profiency. En H. Byrnes (Ed.), Advanced Language Learning: The Contribution of Halliday and Vygotsky (pp. 95–108). London: Continuum) en la interpretación de sus experiencias interculturales, obtenidas en sesiones de telecolaboración con hablantes nativos de español. El análisis cualitativo de los datos muestra cómo la presentación de conceptos teóricos, en lugar de mostrar normas generalizadas relativas al uso de la lengua, permite a los estudiantes participar en una actividad en la que construyen el significado de lo sucedido durante la interacción verbal a través del significado conceptual. Asimismo, esta aproximación sociocultural aplicada estudio de la cortesía ofrece oportunidades de interpretación de experiencias interculturales desde una perspectiva relativista en la que se consideran los factores sociales y culturales específicos de cada comunidad de habla estudiada y permite realizar comparaciones sobre el uso de la lengua en la interacción intercultural. Estas reflexiones y comparaciones son aspectos fundamentales en el desarrollo de la comprensión intercultural.
Memórias e sensibilidades numa produção de conhecimentos histórico-educacionais
Authors: Cunha Nara Rúbia de Carvalho , Prado Guilherme Do Val Toledo 
Published: July 2017

Neste artigo são apresentadas reflexões sobre o trabalho com memórias em um projeto desenvolvido no Museu Casa Guignard, em Ouro Preto-MG, com professores de educação básica, como parte de uma pesquisa de formação docente realizada junto ao programa de Pós-Graduação da Unicamp, de 2012 a 2016. Em diálogo com o filósofo Walter Benjamin, destaca-se a relação entre os sujeitos da pesquisa, potencializada pelo desafio de lidar com as sensibilidades no trabalho científico.
Behavioral Risk Assessment From Newborn to Preschool: The Value of Older Siblings
Authors: Rodrigues Michelle , Binnoon-Erez Noam , Plamondon Andre , Jenkins Jennifer M. 
Published: July 2017

OBJECTIVES:
The aim of this study was to examine the plausibility of a risk prediction tool in infancy for school-entry emotional and behavioral problems. Familial aggregation has been operationalized previously as maternal psychopathology. The hypothesis was tested that older sibling (OS) psychopathology, as an indicator of familial aggregation, would enable a fair level of risk prediction compared with previous research, when combined with traditional risk factors.

METHODS:
By using a longitudinal design, data on child and family risk factors were collected on 323 infants (M = 2.00 months), all of whom had OSs. Infants were followed up 4.5 years later when both parents provided ratings of emotional and behavioral problems. Multiple regression and receiver operating characteristic curve analyses were conducted for emotional, conduct, and attention problems separately.

RESULTS:
The emotional and behavioral problems of OSs at infancy were the strongest predictors of the same problems in target children 4.5 years later. Other risk factors, including maternal depression and socioeconomic status provided extra, but weak, significant prediction. The area under the receiver operating characteristic curve for emotional and conduct problems yielded a fair prediction.

CONCLUSIONS:
This study is the first to offer a fair degree of prediction from risk factors at birth to school-entry emotional and behavioral problems. This degree of prediction was achieved with the inclusion of the emotional and behavioral problems of OSs (thus limiting generalizability to children with OSs). The inclusion of OS psychopathology raises risk prediction to a fair level.
ANALISIS KESESUAIAN SOSIAL-EKOLOGIS PEMANFAATAN SUMBER DAYA PERIKANAN BERDASARKAN PRODUKTIVITAS PRIMER DI KECAMATAN UNA-UNA DAN KABUPATEN TOJO UNA-UNA PROVINSI SULAWESI TENGAH
Authors: Sulistiawati D. , Adrianto Luky , Muchsin I. , Masyahoro A. 
Published: July 2017

Memahami tingkat pemanfaatan sumberdaya alam sangat penting dalam pengelolaan sumberdaya perikanan. Penelitian ini bertujuan untuk menilai keseuaian pemanfaatan sumberdaya perikanan di Kecamatan Una-Una (lokal) dan Kabupaten Tojo Una-Una (regional). Metode yang dilakukan desk study dan survey lapang. Data yang diperoleh dianalisis menggunakan pendekatan HANPP (Human Appropriation of Net Primary Productivity). Hasil yang diperoleh bahwa HANPP lokal sebesar 7,93 109 kJ dengan rasio HANPP-NPP (Net Primary Productivity) sebesar 55,50, sedangkan tingkat regional sebesar 0,93 1012 kJ dengan rasio HANPP-NPP sebesar 28,17. Hal ini menunjukkan bahwa kolonisasi nelayan regional lebih efisien dalam memenuhi kebutuhan produktivitas primernya dibanding nelayan lokal. Tittle: Analysis of Socio-Ecological Suitability of Fishery Resources Exploitation Based on Primary Productivity in the Una Una District and Tojo Una Una Regency of Central Sulawesi Province.Understanding level of natured resource is very important in fisheries managemant. The objectives of thist study is to assess marine fisheries exploitation in the Una-Una district (local scale) and Tojo Una-Una regency (regional scale). This research used a desk and field survey. Data obtained were analyzed using HANPP (Human Appropriation of Net Primary Productivity). Results of the study showed that HANPP at local level 7.93 109 kJ with HANPP-NPP ratio 55.5 while HANPP of regional level was 0.93 1012 kJ with HANPP ratio of 28.17. These results indicated that a colonize regional fishers was more efficient than local fishers in appealling their primary productivity.