bluuebunny/crossref_metadata_2025_split huggingface dataset:
Colonización y Colonialidad
Authors: Dzib Ubaldo 
Published: September 2024

El objetivo de la reseña es mostrar los aportes del libro, Colonización y Colonialidad en una selva de frontera, de Rosa Torras, a la historiografía de la Península de Yucatán, en particular, y a la corriente de pensamiento sobre modernidad y colonialidad, en general. La obra combina la investigación documental y la historia oral para develar el proceso de poblamiento del río Candelaria como una de las regiones menos trabajadas al suroeste de la Península. Los resultados muestran que la colonización de las selvas tropicales de esa región puede ser vista como la construcción de la modernidad a través de los procesos interrelacionados de formación del estado y del capital. Por eso la construcción de la soberanía del estado, la territorialidad regulada y la “comunidad imaginada” en el sur favoreció los intereses de la élite terrateniente carmelita; es decir, la colonización no siguió el camino del poblamiento, sino la ocupación del territorio vía la propiedad privada latifundista y el establecimiento de una economía forestal extractiva que vinculó la región al mercado internacional e impulsó la acumulación de la oligarquía.
Muralismo otomí en una escuela primaria de Guanajuato
Authors: Uzeta Iturbide Jorge 
Published: September 2024

El objetivo principal de esta investigación es el análisis iconográfico de un mural realizado por artistas locales en una comunidad otomí del noreste de Guanajuato. Se argumenta que la creación de esta obra se encuentra relacionada con discusiones sobre patrimonio y con la articulación de un lenguaje común entre grupos locales e instituciones estatales. El enfoque utilizado es inductivo, combina la etnografía con el uso de fuentes secundarias relacionadas con la mitología otomí y con la historia y la política locales. Como resultado se observa que el mural está permeado por una mirada esencialista y por objetivos pedagógicos dirigidos a la propia población otomí, ocultando la diversificación social y las tensiones históricas que han configurado su territorio. Así, el estudio implica una discusión no agotada sobre el actual talante político de las comunidades de interés. Su valor reside en la propia lectura del mural puesto en contexto etnográfico y temporal, y permite concluir que existe un talante negociador entre líderes y grupos otomíes específicos para coincidir y aprovechar ciertos matices del proyecto multicultural oficial.
arte indígena. Algunas pistas para su análisis desde la mirada antropológica
Authors: Morales Carbajal Claudia 
Published: September 2024

Este trabajo nació como una búsqueda para ubicar posibles rutas que pudieran guiar hacia los procesos creativos de los pueblos indígenas mesoamericanos, desde sus propias pautas de desarrollo y su poética particular. El punto de partida son las aportaciones que han contribuido a conformar la antropología del arte, como un campo nuevo de conocimiento con un bagaje teórico metodológico propio. Se hace una revisión por las principales corrientes de pensamiento antropológico que han alimentado este tipo de análisis y han generado herramientas teórico-metodológicas para un acercamiento al arte. Se finaliza con una reflexión en cuanto a la forma como estos marcos de análisis han sido aplicados a la realidad de los procesos creativos de los pueblos originarios de México.
Estrategias para desarrollar el pensamiento filosófico en la educación virtual universitaria derivada de la pandemia
Authors: Cetina Cauich Caleb , Alpuche Rivera Ángel Iván 
Published: September 2024

En la actualidad se han presentado múltiples adversidades para el desarrollo del pensamiento filosófico en la educación superior, debido a todos los cambios que se han generado por la pandemia, ya que las instituciones centraron sus esfuerzos en realizar una adaptación de emergencia a la virtualidad. Por lo anterior, el propósito de este ensayo es analizar la importancia que tiene la filosofía dentro de la formación de los estudiantes de educación superior y las maneras en las que se puede desarrollar mediante los recursos tecnológicos que son indispensables para la educación virtual. Para esto, se realizó una extensa revisión literaria con el fin de conocer el estado actual del pensamiento filosófico en la educación de México y establecer las estrategias utilizadas por docentes de diversas instituciones para incluir estos componentes dentro de sus prácticas educativas virtuales. El análisis muestra que existe mucho camino por recorrer para que el pensamiento filosófico recupere su relevancia como el eje central de la formación de estudiantes universitarios, pero también se encontraron diversos esfuerzos de profesionales que ya se están implementando para conseguirlo.
Assessing non-linear models for galaxy clustering I: unbiased growth forecasts from multipole expansion
Authors: Markovic Katarina , Bose Benjamin , Pourtsidou Alkistis 
Published: September 2024

We assess the performance of the Taruya, Nishimichi and Saito (TNS) model for the halo redshift space power spectrum, focusing on utilising mildly non-linear scales to constrain the growth rate of structure f. Using simulations with volume and number density typical of forthcoming Stage IV galaxy surveys, we determine ranges of validity for the model at redshifts z = 0.5 and z = 1. We proceed to perform a Bayesian MCMC analysis utilising the monopole, quadrupole, and hexadecapole spectra, followed by an exploratory Fisher matrix analysis. As previously noted in other forecasts as well as in real data analyses, we find that including the hexadecapole can significantly improve the constraints. However, a restricted range of scales is required for the hexadecapole in order for the growth parameter estimation to remain unbiased, limiting the improvement. We consistently quantify these effects by employing the multipole expansion formalism in both our Fisher and MCMC forecasts.
Implante imediato em área estética: Da carga imediata ao fluxo digital: Relato de caso clínico e follow-up de 2 anos
Authors: Peralta Felipe da Silva , Serafim Jenifer , Bonelli Sabrina Evelyn de Oliveira , Nascimento Marcelo Pontes do , Barbosa Maylon Luciano Garcia , Affonso Sabrina Quirido , Fischer Tatiana Konrad 
Published: September 2024

A técnica cirúrgica de implante imediato, associada a carga imediata e ao fluxo digital, tem revolucionado a implantodontia, oferecendo solução ágil e eficiente para a reabilitação oral. Os implantes dentários requerem um período cicatricial que pode gerar ansiedade ao paciente, porém, com o uso dessa técnica, os implantes podem ser instalados imediatamente após a extração e recebem carga na mesma hora, favorecendo o processo cicatricial e reduzindo o tempo de tratamento. O fluxo digital, por sua vez, incorpora novas tecnologias, como por exemplo o sistema CEREC CAD/CAM, que possibilita o planejamento dos casos e a fabricação de próteses de alta qualidade. O conceito chairside, sistema CEREC, possibilita a realização de restaurações indiretas em sessão única, no próprio onsultório odontológico. Estudos mostraram que o fluxo digital possibilitou a produção de restaurações estéticas indiretas com taxa de manutenção clínica excepcional. O presente estudo tem como objetivo apresentar uma revisão de literatura acerca do tema implante imediatoem áreaestética e em um relato de caso clínico de implante imediato e carga imediata em paciente reabilitado pelo fluxo digital com o sistema CEREC CAD/CAM.
Exploring the effect of lifestyle behaviors and socioeconomic status on atrial fibrillation: the mediating role of 91 inflammatory cytokines
Authors: Liu Yiheng , Huang Mingsheng , Sun Yue , Dai Weiran 
Published: September 2024

BackgroundAtrial fibrillation (AF) is one of the most prevalent cardiac arrhythmias and has a significant economic and social burden. Whether it is associated with lifestyle behaviors and socioeconomic status is currently poorly understood. This study aimed to explore the relationship among these factors and determine the role of inflammatory cytokines.MethodWe investigated the causal effects of lifestyle behaviors and socioeconomic status on AF using bidirectional two-sample Mendelian randomization (MR). Instrumental variables were obtained from a publicly available genome-wide association study. A two-step MR was conducted to determine the mediating role of 91 inflammatory cytokines. Inverse variance weighted was used as the main method with four supplementary MR methods. To obtain more robust results, several sensitivity analyses were conducted.ResultThe results indicated that seven of the lifestyle behaviors [smoking initiation, vegetable intake, coffee consumption (cups/day), dozing, lifetime smoking index, napping, and alcohol abuse] were potential risk factors for AF. One socioeconomic status, education attainment (years of education), was causally associated with a decreased risk of AF. Moreover, we found that thymic stromal lymphopoietin, CD40l receptor, C-X-C motif chemokine 6, and C-X-C motif chemokine 11 levels mediated the causal effect, at proportions of 13.6%, 4.1%, 4.3%, and 6.9%, respectively.ConclusionOur findings provide insight into the relationship between lifestyle behaviors, socioeconomic status, and AF. Inflammatory cytokines are potential mediators of this relationship.
A comprehensive analysis of the role of native and modified HDL in ER stress in primary macrophages
Authors: Bobek Jordan M. , Stuttgen Gage M. , Sahoo Daisy 
Published: September 2024

IntroductionRecent findings demonstrate that high density lipoprotein (HDL) function rather than HDL-cholesterol levels themselves may be a better indicator of cardiovascular disease risk. One mechanism by which HDL can become dysfunctional is through oxidative modification by reactive aldehydes. Previous studies from our group demonstrated that HDL modified by reactive aldehydes alters select cardioprotective functions of HDL in macrophages. To identify mechanisms by which dysfunctional HDL contributes to atherosclerosis progression, we designed experiments to test the hypothesis that HDL modified by reactive aldehydes triggers endoplasmic reticulum (ER) stress in primary murine macrophages.Methods and resultsPeritoneal macrophages were harvested from wild-type C57BL/6J mice and treated with thapsigargin, oxLDL, and/or HDL for up to 48 hours. Immunoblot analysis and semi-quantitative PCR were used to measure expression of BiP, p-eIF2α, ATF6, and XBP1 to assess activation of the unfolded protein response (UPR). Through an extensive set of comprehensive experiments, and contrary to some published studies, our findings led us to three novel discoveries in primary murine macrophages: (i) oxLDL alone was unable to induce ER stress; (ii) co-incubation with oxLDL or HDL in the presence of thapsigargin had an additive effect in which expression of ER stress markers were significantly increased and prolonged as compared to cells treated with thapsigargin alone; and (iii) HDL, in the presence or absence of reactive aldehydes, was unable blunt the ER stress induced by thapsigargin in the presence or absence of oxLDL.ConclusionsOur systematic approach to assess the role of native and modified HDL in mediating primary macrophage ER stress led to the discovery that lipoproteins on their own require the presence of thapsigargin to synergistically increase expression of ER stress markers. We further demonstrated that HDL, in the presence or absence of reactive aldehydes, was unable to blunt the ER stress induced by thapsigargin in the presence or absence of oxLDL. Together, our findings suggest the need for more detailed investigations to better understand the role of native and modified lipoproteins in mediating ER stress pathways.
Echotexture of recurrent laryngeal nerves: the depiction of recurrent laryngeal nerves at high-frequency ultrasound during radical thyroidectomy
Authors: Hu Ziyue , Lu Man , Jiang Zirui , Wang Xu , Yang Wei , Fan Yuting , Li Tingting , Wang Lu , Wei Ting , Dai Quan 
Published: September 2024

IntroductionTo investigate the ultrasound characteristics of recurrent laryngeal nerves (RLNs) during radical surgery for thyroid cancer and to enhance the understanding of RLN ultrasound features.MethodsFrom October 2021 to December 2022, a prospective study was conducted involving 24 patients scheduled for bilateral thyroid surgery. Near the conclusion of the surgery, intraoperative ultrasonography of the RLN within the tracheoesophageal groove was performed using a 15-7 MHz transducer. The thickness and width of the RLN were measured during the procedure.ResultsThe internal architecture of the RLN was observed to consist of multiple hypoechoic, parallel, but discontinuous linear hyperechoic areas separated by bands. In the normal RLN group, the diameter of the RLN was relatively consistent, with thickness ranging from 2.20 to 2.71 mm (mean: 2.48 ± 0.14 mm) and width from 1.25 to 1.70 mm (mean: 1.45 ± 0.11 mm). Both weight and the body mass index (BMI) showed a statistically significant correlation with RLN thickness (Weight: r=0.544, P=0.001; BMI: r=0.605, P=0.001). The BMI also showed a statistically significant correlation with the RLN width (r=0.377, P=0.033). In the RLN invasion group, the width of invaded RLNs ranged from 1.9 to 2.3 mm (mean: 2.10 ± 0.11 mm), while the width of non-invaded RLNs ranged from 2.6 to 3.2 mm (mean: 2.93 ± 0.20 mm).ConclusionsUltrasound effectively reveals the structural features of the RLN and enhances sonographers’ understanding of RLN characteristics.
A multimodal approach identifies lactate as a central feature of right ventricular failure that is detectable in human plasma
Authors: Hemnes Anna , Fortune Niki , Simon Katie , Trenary Irina A. , Shay Sheila , Austin Eric , Young Jamey D. , Britain Evan , West James , Talati Megha 
Published: September 2024

BackgroundIn PAH metabolic abnormalities in multiple pathways are well-recognized features of right ventricular dysfunction, however, prior work has focused mainly on the use of a single “omic” modality to describe a single deranged pathway. We integrated metabolomic and epigenomic data using transcriptomics in failing and non-failing RVs from a rodent model to provide novel mechanistic insight and translated these findings to accessible human specimens by correlation with plasma from PAH patients.MethodsStudy was conducted in a doxycycline-inducible BMPR2 mutant mouse model of RV failure. Plasma was collected from controls and PAH patients. Transcriptomic and metabolomic analyses were done on mouse RV tissue and human plasma. For mouse RV, we layered metabolomic and transcriptomic data for multiple metabolic pathways and compared our findings with metabolomic and transcriptomic data obtained for human plasma. We confirmed our key findings in cultured cardiomyocyte cells with BMPR2 mutation.ResultsIn failing mouse RVs, (1) in the glycolysis pathway, glucose is converted to lactate via aerobic glycolysis, but may also be utilized for glycogen, fatty acid, and nucleic acid synthesis, (2) in the fatty acid pathway, FAs are accumulated in the cytoplasm because the transfer of FAs to mitochondria is reduced, however, the ß-oxidation pathway is likely to be functional. (3) the TCA cycle is altered at multiple checkpoints and accumulates citrate, and the glutaminolysis pathway is not activated. In PAH patients, plasma metabolic and transcriptomic data indicated that unlike in the failing BMPR2 mutant RV, expression of genes and metabolites measured for the glycolysis pathway, FA pathway, TCA cycle, and glutaminolysis pathway were increased. Lactate was the only metabolite that was increased both in RV and circulation. We confirmed using a stable isotope of lactate that cultured cardiomyocytes with mutant BMPR2 show a modest increase in endogenous lactate, suggesting a possibility of an increase in lactate production by cardiomyocytes in failing BMPR2 mutant RV.ConclusionIn the failing RV with mutant BMPR2, lactate is produced by RV cardiomyocytes and may be secreted out, thereby increasing lactate in circulation. Lactate can potentially serve as a marker of RV dysfunction in PAH, which warrants investigation.
Clinical factors associated with invasive pulmonary aspergillosis in patients with severe fever with thrombocytopenia syndrome: analysis of a 6-year clinical experience
Authors: Wang Huan , Luo Miao , Fisher David , Pronyuk Khrystyna , Musabaev Erkin , Thu Hien Nguyen Thi , Ye Pian , Zhao Lei 
Published: September 2024

BackgroundInvasive pulmonary aspergillosis (IPA) typically occurs in immunocompromised individuals. Severe fever with thrombocytopenia syndrome (SFTS) patients are typically characterized by fever, thrombocytopenia, and leukopenia. These patients typically present with dysregulation of cellular and humoral immunity, which may predispose them to IPA. Our study aimed to identify risk factors for SFTS-associated invasive pulmonary aspergillosis (SAPA) and evaluate its associated prognostic impact.MethodsWe conducted a cohort study between January 2017 and December 2022 in a tertiary hospital in Wuhan City, China. All SFTS patients hospitalized in our department who formally consented were divided into a SAPA group and a non-SAPA group according to whether they were coinfected with aspergillosis or not. The independent risk factors for the SAPA group were determined by multivariate logistic regression. Receiver operating characteristic (ROC) analysis was used to assess the statistical value of parameters to predict SAPA patients. The survival analysis was carried out using the Kaplan–Meier (KM) method.ResultsOf the 269 hospitalized SFTS patients enrolled in the study, 118 (43.87%) cases were diagnosed with SAPA with an average age of 65.71 ± 9.7 years. Multivariate logistic regression analysis revealed that age, neurological complications, serum severe fever with thrombocytopenia syndrome virus (SFTSV) RNA loads, the white blood cell (WBC) count, platelet (PLT) count, albumin (ALB) and globulin (GLB) concentrations, and cardiac troponin I (cTNI) were complementary risk factors for the development of IPA in SFTS patients. The risk score is calculated as 5 times age, plus 6 times neurological complications, plus 10 times RNA (log), plus 5 times WBC, minus 5 times PLT, minus 5 times ALB, plus 5 times GLB, and plus 6 times cTNI. ROC curve analysis showed that the area under the receiver operating characteristic (AUROC) curve represented a risk score of 0.837 (95% CI: 0.789–0.885, p &lt; 0.001) for predicting IPA in SFTS patients. The average length of hospitalization in the SAPA group was more prolonged than non-SAPA. SAPA and non-SAPA groups had significantly different mortality rates: 25.42% (SAPA) and 3.97% (non-SAPA) (p &lt; 0.05).ConclusionSFTS patients with IPA have high morbidity and mortality. Early monitoring of neurological complications, SFTSV RNA loads, WBC, PLT, ALB, GLB, and cTNI in SFTS patients may be useful in predicting the occurrence of IPA.
Top-down modulation of dichotic listening affects interhemispheric connectivity: an electroencephalography study
Authors: Elyamany Osama , Iffland Jona , Lockhofen Denise , Steinmann Saskia , Leicht Gregor , Mulert Christoph 
Published: September 2024

IntroductionDichotic listening (DL) has been extensively used as a task to investigate auditory processing and hemispheric lateralisation in humans. According to the “callosal relay model,” the typical finding of a right ear advantage (REA) occurs because the information coming from the right ear has direct access to the left dominant hemisphere while the information coming from the left ear has to cross via the corpus callosum. The underlying neuroanatomical correlates and neurophysiological mechanisms have been described using diffusion tensor imaging (DTI) and lagged phase synchronization (LPS) of the interhemispheric auditory pathway. During the non-forced condition of DL, functional connectivity (LPS) of interhemispheric gamma-band coupling has been described as a relevant mechanism related to auditory perception in DL. In this study, we aimed to extend the previous results by exploring the effects of top-down modulation of DL (forced-attention condition) on interhemispheric gamma-band LPS.MethodsRight-handed healthy participants (n = 31; 17 females) performed three blocks of DL with different attention instructions (no-attention, left-ear attention, right-ear attention) during simultaneous EEG recording with 64 channels. Source analysis was done with exact low-resolution brain electromagnetic tomography (eLORETA) and functional connectivity between bilateral auditory areas was assessed as LPS in the gamma-band frequency range.ResultsTwenty-four participants (77%) exhibited a right-ear advantage in the no-attention block. The left- and right-attention conditions significantly decreased and increased right-ear reports, respectively. Similar to the previous studies, functional connectivity analysis (gamma-band LPS) showed significantly increased connectivity between left and right Brodmann areas (BAs) 41 and 42 during left ear reports in contrast with right ear reports. Our new findings notably indicated that the right-attention condition exhibited significantly higher connectivity between BAs 42 compared with the no-attention condition. This enhancement of connectivity was more pronounced during the perception of right ear reports.DiscussionOur results are in line with previous reports describing gamma-band synchronization as a relevant neurophysiological mechanism involved in the interhemispheric connectivity according to the callosal relay model. Moreover, we newly added some evidence of attentional effects on this interhemispheric connectivity, consistent with the attention-executive model. Our results suggest that reciprocal inhibition could be involved in hemispheric lateralization processes.
In-depth analysis of OTC A208T case induced by OTC gene mutation and research on the prediction and simulation of the impact on protein function
Authors: Hu Qingyang , Chen Haiming , Liu Tianyi , Dong Xue , Hu Xuejiao , Yan Wenxin , Li Zhong 
Published: September 2024

BackgroundOrnithine transcarbamylase deficiency (OTCD), a rare hereditary disease caused by gene mutation of ornithine transcarbamylase (OTC), is the most prevalent type among urea cycle disorders. OTCD typically leads to mitochondrial enzyme dysfunction, preventing the synthesis of citrulline from carbamoyl phosphate and ornithine, and is characterized by a remarkable increase in blood ammonia. Specific symptoms may include neurological abnormalities, growth retardation, and other manifestations.MethodsWe presented a case of a child diagnosed with OTCD (OMIM: 311250). By using whole-genome sequencing (WGS) for the pedigree and in-depth whole-exome sequencing (WES), we aimed to identify the disease-causing genes. Gene mutation prediction tools were employed to verify the pathogenicity, and the molecular dynamics simulation method was utilized to assess the impact of this mutation on the activity and structural stability of the OTC protein.ResultsWhole-exome sequencing detected an OTC variant [NM_000531: c.622 (exon6) G &gt; A, p.A208T]. Through comprehensive analysis with various gene mutation prediction tools and in line with the ACMG guidelines, this mutation site was firmly established as a pathogenic site. Moreover, the molecular dynamics simulation results clearly demonstrated that this mutation would significantly compromise the stability of the OTC protein structure.ConclusionThis study deepens our understanding of the clinical manifestations and characteristics of OTCD, especially the OTC A208T gene mutation site. Given the lack of specific clinical manifestations in OTCD patients, early and accurate diagnosis is crucial for effective treatment and prognosis improvement. To our knowledge, this is the first case of this mutation site reported in China.