bluuebunny/crossref_metadata_2025_split huggingface dataset:
A polyalanine antibody for the diagnosis of oculopharyngeal muscular dystrophy and polyalanine-related diseases
Authors: Stochmanski Shawn J. , Blondeau François , Girard Martine , Hince Pascale , Rochefort Daniel , Gaspar Claudia , Dion Patrick A. , McPherson Peter S. , Rouleau Guy A. 
Published: December 2017

Eighteen severe human diseases have so far been associated with trinucleotide repeat expansions coding for either polyalanine (encoded by a GCN repeat tract) or polyglutamine (encoded by a CAG repeat tract). Among them, oculopharyngeal muscular dystrophy (OPMD), spinocerebellar ataxia type-3 (SCA3), and Huntington’s disease (HD) are late-onset autosomal-dominant disorders characterized by the presence of intranuclear inclusions (INIs). We have previously identified the OPMD causative mutation as a small expansion (from 2 in normal to 7 in disease) of a GCG repeat tract in the PABPN1 gene. In addition, -1 ribosomal frameshifting has been reported to occur in expanded CAG repeat tracts in the ATXN3 (SCA3) and HTT (HD) genes, resulting in the translation of a hybrid CAG/GCA repeat tract and the production of a polyalanine-containing peptide. Previous studies on OPMD suggest that polyalanine-induced toxicity is very sensitive to the dosage and length of the alanine stretch. Here we report the characterization of a polyclonal antibody that selectively recognizes pathological expansions of polyalanine in PABPN1. Furthermore, our antibody also detects the presence of alanine proteins in INIs of SCA3 and HD patient samples.
Healthcare choices in Mumbai slums: A cross-sectional study
Authors: Naydenova Elina , Raghu Arvind , Ernst Johanna , Sahariah Sirazul A. , Gandhi Meera , Murphy Georgina 
Published: December 2017

Background: Informal urban settlements, known as slums, are the home for a large proportion of the world population. Healthcare in these environments is extremely complex, driven by poverty, environmental challenges, and poor access to formal health infrastructures. This study investigated healthcare challenges faced and choices made by slum dwellers in Mumbai, India. Methods: Structured interviews with 549 slum dwellers from 13 slum areas in Mumbai, India, were conducted in order to obtain a population profile of health-related socio-economic and lifestyle factors, disease history and healthcare access. Statistical tools such as multinomial logistic regression were used to examine the association between such factors and health choices. Results: Private providers (or a mixture of public and private) were seen to be preferred by the study population for most health conditions (62% - 90% health consultations), apart from pregnancy (43% health consultations). Community-based services were also preferred to more remote options. Stark differences in healthcare access were observed between well-known conditions, such as minor injuries, pulmonary conditions, and pregnancy and emerging challenges, such as hypertension and diabetes. A number of socio-economic and lifestyle factors were found to be associated with health-related decisions, including choice of provider and expenditure. Conclusions: Better planning and coordination of health services, across public and private providers, is required to address mortality and morbidity in slum communities in India. This study provides insights into the complex landscape of diseases and health providers that slum dwellers navigate when accessing healthcare. Findings suggest that integrated services and public-private partnerships could help address demand for affordable community-based care and progress towards the target of universal health coverage.
ОТРАЖЕНИЕ САМОИДЕНТИФИКАЦИИ В РЕГИОНАЛЬНЫХ ПЕЧАТНЫХ СРЕДСТВАХ МАССОВОЙ ИНФОРМАЦИИ
Authors: Shmul’skaya Larisa Stepanovna , Slavkina Inga Anatol’evna , Mamaeva Svetlana Victorovna , Vekkesser Mariya Victorovna 
Published: December 2017

Предметом исследования явились способы отражения и лингвистического выражения территориальной идентичности в печатных региональных средствах массовой информации. Материалом изучения избраны печатные издания Приенисейского региона: «Заря Енисея» (городская общественно-политическая газета города Лесосибирска), «Ангарский рабочий» (общественно-политическая газета Мотыгинского района), «Енисейская правда» (общественно-политическая газета г. Енисейска и Енисейского района), «Заря» (общественно-политическая газета Пировского района Красноярского края), «Северо-Енисейский вестник» (муниципальная газета Северо-Енисейского района), «новая жизнь» (Казачинская общественно-политическая газета Красноярского края).Цель. Рассмотреть понятие «региональная идентичность» и выявить маркеры территориальной идентичности в региональных печатных СМИ.Методы исследования: описательный метод и метод контекстуального анализа.Результаты. Региональная идентичность определяется как форма коллективной идентичности, при которой ее носитель оказывается способным к пространственно-временной идентификации, ценностному, эмоциональному, регулятивному соотнесению с внешним миром. При анализе текстов региональных газет выявлены определённые черты, отражающие и формирующие территориальную «самость», что свойственно провинциальным газетам в целом и отличает их от федеральных СМИ. Установлено, что средства массовой информации могут рассматриваться как средства формирования, выражения и трансляции региональных ценностей и являются действенным средством отражения и моделирования территориальной идентичности.
Paediatric tibial shaft fractures treated by open reduction and stabilization with monolateral external fixation
Authors: Simon A.-L. , Apostolou N. , Vidal C. , Ferrero E. , Mazda K. , Ilharreborde B. 
Published: December 2017

Purpose Elastic stable intramedullary nailing is increasingly used for surgical treatment of tibial shaft fractures, but frequently requires immobilization and delayed full weight-bearing. Therefore, external fixation remains interesting. The aim was to report clinico-radiological outcomes of monolateral external fixation for displaced and unstable tibial shaft fractures in children. Methods All tibial fractures consecutively treated by monolateral external fixation between 2008 and 2013 were followed. Inclusion criteria included skeletal immaturity and closed and open Gustilo I fractures caused by a direct impact. Patients were seen until two years postoperatively. Demographics, mechanism of injury, surgical data and complications were recorded. Anteroposterior and lateral side radiographs were performed at each visit. Full-limb 3D reconstructions using biplanar stereroradiography was performed for final limb length and alignment measures. Results A total of 45 patients (mean age 9.7 years ± 0.5) were included. In all, 17 were Gustilo I fractures, with no difference between open and closed fractures for any data. Mean time to full weight bearing was 18.2 days ± 0.7. After 15 days, 39 patients returned to school. Hardware removal (mean time to union 15.6 weeks ± 0.8) was performed during consultation under analgesic gas. There were no cases of nonunion. No fracture healed with > 10° of angulation (mean 5.1° ± 0.4°). Leg-length discrepancy > 10 mm was found for six patients. Conclusions This procedure can be a safe and simple surgical treatment for children with tibial shaft fractures. Few complications and early return to school were reported, with the limitations of non-comparative study. Level of Evidence IV
Identification of potential pathogenic genes associated with osteoporosis
Authors: Xia B. , Li Y. , Zhou J. , Tian B. , Feng L. 
Published: December 2017

ObjectivesOsteoporosis is a chronic disease. The aim of this study was to identify key genes in osteoporosis.MethodsMicroarray data sets GSE56815 and GSE56814, comprising 67 osteoporosis blood samples and 62 control blood samples, were obtained from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) were identified in osteoporosis using Limma package (3.2.1) and Meta-MA packages. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed to identify biological functions. Furthermore, the transcriptional regulatory network was established between the top 20 DEGs and transcriptional factors using the UCSC ENCODE Genome Browser. Receiver operating characteristic (ROC) analysis was applied to investigate the diagnostic value of several DEGs.ResultsA total of 1320 DEGs were obtained, of which 855 were up-regulated and 465 were down-regulated. These differentially expressed genes were enriched in Gene Ontology terms and Kyoto Encyclopedia of Genes and Genomes pathways, mainly associated with gene expression and osteoclast differentiation. In the transcriptional regulatory network, there were 6038 interactions pairs involving 88 transcriptional factors. In addition, the quantitative reverse transcriptase-polymerase chain reaction result validated the expression of several genes (VPS35, FCGR2A, TBCA, HIRA, TYROBP, and JUND). Finally, ROC analyses showed that VPS35, HIRA, PHF20 and NFKB2 had a significant diagnostic value for osteoporosis.ConclusionGenes such as VPS35, FCGR2A, TBCA, HIRA, TYROBP, JUND, PHF20, NFKB2, RPL35A and BICD2 may be considered to be potential pathogenic genes of osteoporosis and may be useful for further study of the mechanisms underlying osteoporosis. Cite this article: B. Xia, Y. Li, J. Zhou, B. Tian, L. Feng. Identification of potential pathogenic genes associated with osteoporosis. Bone Joint Res 2017;6:640–648. DOI: 10.1302/2046-3758.612.BJR-2017-0102.R1.
Cytokines in tendon disease
Authors: Morita W. , Dakin S. G. , Snelling S. J. B. , Carr A. J. 
Published: December 2017

ObjectivesEmerging evidence indicates that tendon disease is an active process with inflammation that is critical to disease onset and progression. However, the key cytokines responsible for driving and sustaining inflammation have not been identified.MethodsWe performed a systematic review of the literature using MEDLINE (U.S. National Library of Medicine, Bethesda, Maryland) in March 2017. Studies reporting the expression of interleukins (ILs), tumour necrosis factor alpha (TNF-α) and interferon gamma in diseased human tendon tissues, and animal models of tendon injury or exercise in comparison with healthy control tissues were included.ResultsIL-1β, IL-6, IL-10, and TNF-α are the cytokines that have been most frequently investigated. In clinical samples of tendinopathy and tendon tears, the expression of TNF-α tended not to change but IL-6 increased in tears. Healthy human tendons showed increased IL-6 expression after exercise; however, IL-10 remained unchanged. Animal tendon injury models showed that IL-1β, IL-6, and TNF-α tend to increase from the early phase of tendon healing. In animal exercise studies, IL-1β expression showed a tendency to increase at the early stage after exercise, but IL-10 expression remained unchanged with exercise.ConclusionsThis review highlights the roles of IL-1β, IL-6, IL-10, and TNF-α in the development of tendon disease, during tendon healing, and in response to exercise. However, there is evidence accumulating that suggests that other cytokines are also contributing to tendon inflammatory processes. Further work with hypothesis-free methods is warranted in order to identify the key cytokines, with subsequent mechanistic and interaction studies to elucidate their roles in tendon disease development. Cite this article: W. Morita, S. G. Dakin, S. J. B. Snelling, A. J. Carr. Cytokines in tendon disease: A Systematic Review. Bone Joint Res 2017;6:656–664. DOI: 10.1302/2046-3758.612.BJR-2017-0112.R1.
Development of a German fracture register to assess current fracture care and improve treatment quality
Authors: Beirer Marc , Kirchhoff Chlodwig , Biberthaler Peter 
Published: December 2017

Continuous evaluation of current treatment methods is crucial in orthopaedic trauma surgery. Existing fracture registries substantially contribute to improving fracture care and quality of life in trauma patients. Currently there is no universal German fracture register recording the patient-centred outcome of non-surgical as well as surgical fracture treatment in all anatomical regions. Conclusions regarding nationwide fracture treatment and quality of care are only significant to a limited extent. Cite this article: EFORT Open Rev 2017;2:474–477. DOI: 10.1302/2058-5241.2.160086.
Marathi cinema: Notes towards a liminal history
Authors: Ingle Hrishikesh 
Published: December 2017

Abstract
Marathi cinema is a prominent regional film industry located in Mumbai, Pune and Kolhapur in western India. Since its early history, this film industry has evolved within a network of performance forms like the Marathi theatre, folk music and dance, and devotional singing (abhanga and kirtan), and the inter-exchange of personnel between these cultural formations. When the state of Maharashtra was constituted in 1960, this networked formation became even more prominent, and had to negotiate the rising competition from the more dominant Hindi cinema. Marathi cinema also had to contend with the patronage of Marathi audiences for other artistic forms like the theatre and folk performances. The attempt here is to theorize this state of in-betweenness through a spatial detailing and critical mapping of industrial tendencies, textual practices and regional entrenchment. The questions that informs this study are directed to understand regional cinema in India, and its manifestations over the decades of 1960 to 1980. Specifically, the article forwards some propositions to the ideas of: how can the history of Marathi cinema be situated against the dominant and collocative national Hindi cinema industry, with which it shares a common geography of filmmaking, exhibition and audiences? And how the concepts of social and cultural space can be extended to analyse some distinctive historical tendencies of the Marathi cinema? This analysis proposes a dialectics of space for a regional Marathi film practice, which is confirmed by a reading of films, anecdotal biographies, archival materials and trade journals.
I like the unpath best: Art-practice-writing and the creation of complex, generative and complicating forms and contexts
Authors: Thomson Amanda 
Published: December 2017

Abstract
Situating myself as a visual artist with a multimodal practice, this article will explore the relationship of writing to making, using the relationship of writing to my own practice to explore questions relating to research processes, the volume of information gathered and the insertion of other disciplinary perspectives. Here, I will address the element of my practice that is based in landscape, specifically explorations that begin with the idea that places are multilayered, ever-changing, embodied and always active. In seeing places as experiential fields of investigation, writing can add a more complex dimension as it flows from the landscape itself and research about it, to practice, with writing occasionally becoming the artform itself.
Encoding pigments and pixels
Authors: Doty Dennis 
Published: December 2017

Abstract
This article will explore the processes and concepts embedded within Dennis Doty’s fine arts studio practice, giving examples of how the work has developed from traditional paintings into its current interdisciplinary form. It examines why it is important to integrate traditional art-making skills with contemporary new media software and approaches. The article aims to illuminate some of the complex interdisciplinary processes that Doty employs to develop multiple bodies of work, including stereoscopic video paintings and projection-mapping artworks. His work explores ideas of spatial perception and the changes that have been happening to our understanding of both physical and digital environments since the invention of the Internet. Doty’s processes demonstrate ways of finding connections between different mediums, analysing and unifying components in a way that can be helpful and inspiring for various professional fields.
Pengaruh penerapan carbohydrate loading modifikasi terhadap kesegaran jasmani atlet sepak bola
Authors: Utoro Bayu Febri , Dieny Fillah Fithra 
Published: December 2017

Background: The reduction of glycogen stores gradually during sports activities affect the performance of athletes. Carbohydrate loading is a method that aims to increase the glycogen stores are expected to delay fatigue and prevent hypoglycemia at the time of the matchPurpose: The purpose of this study was to verify the effect of modification carbohydrate loading to the physical fitness and some indicators of nutritional status soccer athletesMethods: Experimental studies with approaches one group pre and post test design on 23 athletes aged 14-20 years in Diklat Sepak Bola Bintang Pelajar Semarang Regency in July 2011. During one week the subjects were given a high carbohydrate intake approximately 70% of the total energy requirement (protein and fat are given to normal) and soccer practice programmed with moderate intensity in the first three days and continued the intensity of light at the second of three days. Measurements included weight, height, percent body fat, lean body mass, blood glucose levels and physical fitness with Asian Committee on the Standarization of Physical Fitness Test (ACSPFT) methodResults: There were significant differences of physical fitness, physical fitness components (speed and cardiorespiratory endurance), body mass index, percent fat, lean body mass and blood glucose levels before and after treatment with p <0.05Conclusion: Modified carbohydrate loading effected on physical fitness of soccer athletes. Fat mass and lean body mass to be the most influence factors on physical fitness
The Invention of Buddho-Taoism: Critical Historiography of a Western Neologism, 1940s–2010s
Authors: Espesset Grégoire 
Published: December 2017

Abstract
“Buddho-Taoism” is a neologism that appeared in Western academic writings during the late nineteen-forties, was put to various uses without ever being consensually defined, enjoyed a brief vogue around the turn of the twenty-first century, and began to fall from grace in recent years. Not only did this neologism implicitly create new epistemic repertoires derived from the names of two presumably known religions. Increasingly loaded with a heterogeneous subtext pertaining to Western-centred representations of the non-European Other, it has become a highly versatile speech unit. By contextualising the appearance of “Buddho-Taoism” and its attested variants in European-language writings and following their semantic evolution, this essay attempts to shed light on some of the problems raised by its retrospective implementation in contemporary Western discourse on China. It also illustrates the power of seduction of trendy terms that academics tend to overuse without careful consideration for their meaning, thereby adding unnecessary problems to the intrinsic difficulties of their primary materials.
„Was tun im Notfall – Networking, Prävention, Management“
Authors: Balihar Elisabeth 
Published: December 2017

Zusammenfassung
Am 7. September 2017 veranstaltete das Kompetenzzentrum Bestandserhaltung für Archive und Bibliotheken in Berlin und Brandenburg (KBE) den „7. Tag der Bestandserhaltung“ für MitarbeiterInnen aus Archiven, Bibliotheken und Interessierte aus anderen Bereichen. Das aktuelle Motto „Was tun im Notfall – Networking, Prävention, Management“ führte zu einer schnell ausgebuchten und sehr spannenden Tagung mit einem großen praktischen Teil am Nachmittag.
Makulierung als Teil des Bestandsmanagements
Authors: Hommes Klaus Peter 
Published: December 2017

Zusammenfassung
Die Aussonderung von Beständen gehört ebenso wie die Erwerbung zum Bestandsmanagement Öffentlicher Bibliotheken. Neben die Erhebung von Kennzahlen wie Aktivierungsgrad und Absenzquoten treten sachspezifische und bibliothekspolitische Entscheidungen, um einen attraktiven und aktuellen Medienbestand anzubieten.
Minimax Rates for Statistical Inverse Problems Under General Source Conditions
Authors: Ding Litao , Mathé Peter 
Published: December 2017

Abstract
We describe the minimax reconstruction rates in linear ill-posed
equations in Hilbert space when smoothness is given in terms of
general source sets. The underlying fundamental result, the minimax
rate on ellipsoids, is proved similarly to the seminal study by
D. L. Donoho, R. C. Liu, and B. MacGibbon [4]. These
authors highlighted the special role of the truncated series
estimator, and for such estimators the risk can explicitly be given.
We provide several examples, indicating results for
statistical estimation in ill-posed problems in Hilbert space.
Mixing coded systems
Authors: Dastjerdi Dawoud Ahmadi , Dabbaghian Amiri Maliheh 
Published: December 2017

Abstract
We show that a coded system is mixing if and only if it is totally transitive. If in addition it has a generator the length of whose elements are relatively prime, then it has strong property P.
We continue by showing that a mixing half-synchronized system has such a generator. Moreover, we give an example of a mixing coded system which does not have any generator the length of whose elements are relatively prime.
Emblica officinalis – Anti-obesity activity
Authors: Nazish Iram , Ansari Shahid H 
Published: December 2017

Abstract

Context

Emblica officinalis Gaertn. (family-Phyllanthaceae) fruits, known commonly as amla, is extensively used in Indian traditional system of medicine for the treatment of various disorders. The ethanolic E. officinalis extract is reported to have various activity such as antidiabetic, antihyperlipidemic and antioxidant activity in experimental animals.

Objective
To evaluate anti-obesity effect of aqueous E. officinalis extract in murine model of high fat diet (HFD)-induced obesity.

Materials and methods
Male Wistar rats fed with HFD (20 g/day/rat, p.o) for a period of 42 days were used to induce obesity. Aqueous E. officinalis extract (20 mg/kg bw) administered orally to HFD-fed rats from day 8 to 50 days for a period of 42 days. Body weight gain, serum lipids, insulin and leptin parameters were measured.

Results
Oral feeding of the aqueous E. officinalis extract (20 mg/kg) to HFD-induced obese rats for a period of 42 days resulted in significant reduction in body weight gain, insulin, leptin, lipids as compared to rats fed HFD alone. Further, the extract also showed significant increase in high density lipoprotein (HDL-C) levels.

Discussion and conclusions
These results show that aqueous E. officinalis extract possess significant anti-obesity potential.
Galen vein aneurysm– challenge for treatment
Authors: Crnogorac Snezana , Bozaric Aleksandra Vuksanovic 
Published: December 2017

Abstract
The term vein of Galen aneurysm is related to a group of different vascular anomalies, with one common distinction being the dilatation of the vein of Galen. It represents a rear vascular anomaly, whose incidence is yet unknown, although some authors suggest numbers around 1:25000 deliveries. It accounts for only 1% of all intracranial malformations, but the percentage of this anomaly in pediatric populations is up to 30%. In most cases the diagnosis is made postnatal, while antenatal diagnosis, because of the pathophysiology of aneurysm itself, as well as pathophysiology of its possible complications, is made usually during the third trimester, frequently after the 34th week of gestation. The earliest reported diagnosis was made at 25 weeks’ gestation. In this case we present 25-year old gravida, pregnancy at 28th week of gestation with aneurysm, and sonographically detected aneurysm of the vein of Galen, that ended with termination of pregnancy.