bluuebunny/crossref_metadata_2025_split huggingface dataset:
„Ja“ zum neuen UrhWissG!
Authors: Strohschneider Peter 
Published: July 2017

AbstractDer Kampf ums Urheberrecht eskaliert: Der Gesetzentwurf der Bundesregierung berücksichtigt erstmals angemessen die Erfordernisse von Forschung und Lehre im digitalen Zeitalter. Doch die Verlage bekämpfen den fairen Interessenausgleich der geplanten „Wissenschaftsschranken“ mit fast schrankenloser Agitation. Davon darf sich der Bundestag nicht beirren lassen.
Combined tumor genomic profiling and exome sequencing in a breast cancer family implicates ATM in tumorigenesis: A proof of principle study
Authors: Bubien Virginie , Bonnet Françoise , Dupiot‐Chiron Jennifer , Barouk‐Simonet Emmanuelle , Jones Natalie , de Reynies Aurélien , MacGrogan Gaëtan , Sevenet Nicolas , Letouzé Eric , Longy Michel 
Published: July 2017

AbstractFamilial breast cancers (BCs) account for 10%‐20% of all diagnosed BCs, yet only 20% of such tumors arise in the context of a germline mutation in known tumor suppressor genes such as BRCA1 or BRCA2. The vast genetic heterogeneity which characterizes non BRCA1 and non BRCA2 (or BRCAx) families makes grouped studies impossible to perform. Next generation sequencing techniques, however, allow individual families to be studied to identify rare and or private mutations but the high number of genetic variants identified need to be sorted using pathogenicity or recurrence criteria. An additional sorting criterion may be represented by the identification of candidate regions defined by tumor genomic rearrangements. Indeed, comparative genomic hybridization (CGH) using single nucleotide polymorphism (SNP) arrays allows the detection of conserved ancestral haplotypes within recurrent regions of loss of heterozygosity, common to several familial tumors, which can highlight genomic loci harboring a germline mutation in cancer predisposition genes. The combination of both exome sequencing and SNP array‐CGH for a series of familial BC revealed a germline ATM mutation associated with a loss of the wild‐type allele in two BC from a BRCAx family. The analysis of additional breast tumors from ten BC families in which a germline ATM mutation had been identified revealed a high frequency of wild‐type allele loss. This result argues strongly in favor of the involvement of ATM in these tumors as a tumor suppressor gene and confirms that germline ATM mutations are involved in a subset of familial BC.
Management algorithms for cervical cancer screening and precancer treatment for resource‐limited settings
Authors: Basu Partha , Meheus Filip , Chami Youssef , Hariprasad Roopa , Zhao Fanghui , Sankaranarayanan Rengaswamy 
Published: July 2017

AbstractManagement algorithms for screen‐positive women in cervical cancer prevention programs have undergone substantial changes in recent years. The WHO strongly recommends human papillomavirus (HPV) testing for primary screening, if affordable, or if not, then visual inspection with acetic acid (VIA), and promotes treatment directly following screening through the screen‐and‐treat approach (one or two clinic visits). While VIA‐positive women can be offered immediate ablative treatment based on certain eligibility criteria, HPV‐positive women need to undergo subsequent VIA to determine their eligibility. Simpler ablative methods of treatment such as cryotherapy and thermal coagulation have been demonstrated to be effective and to have excellent safety profiles, and these have become integral parts of new management algorithms. The challenges faced by low‐resource countries are many and include, from the management perspective, identifying an affordable point‐of‐care HPV detection test, minimizing over‐treatment, and installing an effective information system to ensure high compliance to treatment and follow‐up.
Scaling up proven innovative cervical cancer screening strategies: Challenges and opportunities in implementation at the population level in low‐ and lower‐middle‐income countries
Authors: Holme Francesca , Kapambwe Sharon , Nessa Ashrafun , Basu Partha , Murillo Raul , Jeronimo Jose 
Published: July 2017

AbstractThe problem of cervical cancer in low‐ and lower‐middle‐income countries (LLMICs) is both urgent and important, and calls for governments to move beyond pilot testing to population‐based screening approaches as quickly as possible. Experiences from Zambia, Bangladesh, Guatemala, Honduras, and Nicaragua, where scale‐up of evidence‐based screening strategies is taking place, may help other countries plan for large‐scale implementation. These countries selected screening modalities recommended by the WHO that are within budgetary constraints, improve access for women, and reduce health system bottlenecks. In addition, some common elements such as political will and government investment have facilitated action in these diverse settings. There are several challenges for continued scale‐up in these countries, including maintaining trained personnel, overcoming limited follow‐up and treatment capacity, and implementing quality assurance measures. Countries considering scale‐up should assess their readiness and conduct careful planning, taking into consideration potential obstacles. International organizations can catalyze action by helping governments overcome initial barriers to scale‐up.
Progress in HPV vaccination in low‐ and lower‐middle‐income countries
Authors: LaMontagne D. Scott , Bloem Paul J.N. , Brotherton Julia M.L. , Gallagher Katherine E. , Badiane Ousseynou , Ndiaye Cathy 
Published: July 2017

AbstractThe past 10 years have seen remarkable progress in the global scale‐up of human papillomavirus (HPV) vaccinations. Forty‐three low‐ and lower‐middle‐income countries (LLMICs) have gained experience in delivering this vaccine to young adolescent girls through pilot programs, demonstration programs, and national introductions and most of these have occurred in the last 4 years. The experience of Senegal is summarized as an illustrative country case study. Publication of numerous delivery experiences and lessons learned has demonstrated the acceptability and feasibility of HPV vaccinations in LLMICs. Four areas require dedicated action to overcome remaining challenges to national scaling‐up: maintaining momentum politically, planning successfully, securing financing, and fostering sustainability. Advances in policy, programming, and science may help accelerate reaching 30 million girls in LLMICs with HPV vaccine by 2020.
Pattern search approach to ferromagnetic material modelling
Authors: Cardelli E. , Faba A. , Pompei M. , Quondam Antonio S. 
Published: July 2017

AbstractThis paper deals with possible optimization‐based techniques for the identification of the parameters of Preisach‐inspired phenomenological model of vector hysteresis in ferromagnetic materials. After a summary of the key features of the phenomenological model mentioned above, the description of the identification technique proposed is given. The identification technique is based on a suitable pattern search algorithm and standard measurements. Results for the FeSi Non‐Oriented Grains steel NOG are presented and discussed.
Work as good‐minded undertakings and effortless assignments: Chinese meaning of working for hospitality workers and its motivational implications
Authors: Hsu Ryan Shuwei , Stanworth James O. 
Published: July 2017

SummaryMeaning of working (MOW) or the understanding of the purpose of working is a cornerstone in organizational behavior. This study answers the call to explain the MOW in Eastern contexts characterized by interdependent identities. We collect our data from hospitality workers in Taiwan, where Chinese Confucian and Taoist cultural precepts are strong. Our findings reveal that our informants use 25 typical vocabularies of motive in establishing and maintaining five salient identities that gain significance through two Chinese work meanings (i.e., good‐minded undertakings and effortless assignments). These meanings demonstrate the theoretical contributions of our findings to the MOW literature. We also explore the interplay between our emic findings (grounded in Taoism and Confucianism Chinese cultures) with etic motivation theory to advance understanding of prevention and promotion foci.
Improving the grid frequency by optimal design of model predictive control with energy storage devices
Authors: Elsisi M. , Soliman M. , Aboelela M.A.S. , Mansour W. 
Published: July 2017

SummaryThis paper proposes the optimal design of model predictive control (MPC) with energy storage devices by the bat‐inspired algorithm (BIA) as a new artificial intelligence technique. Bat‐inspired algorithm‐based coordinated design of MPCs with superconducting magnetic energy storage (SMES) and capacitive energy storage (CES) is proposed for load frequency control. Three‐area hydrothermal interconnected power system installed with MPC and SMES is considered to carry out this study. The proposed design procedure can account for generation rate constraints and governor dead bands. Transport time delays imposed by governors, thermodynamic processes, and communication telemetry can be captured as well. In recent papers, the parameters of MPC with SMES and CES units are typically set by trial and error or by the designer's expertise. This problem is solved here by applying BIA to tune the parameters of MPC with SMES and CES units simultaneously to minimize the deviations of frequency and tie line powers against load perturbations. Simulation results are carried out to emphasize the superiority of the proposed coordinated design as compared with conventional proportional‐integral controller and with BIA‐based MPC without SMES and CES units.
Ultrasonic‐assisted synthesis and enhancement of chitosan/graphene nanosheet composites
Authors: Wu Guangyu , Huang Tianqi , Huang Jianguo 
Published: July 2017

This study investigated a simple and low‐cost method for synthesizing graphene nanosheet/chitosan (GNS/CS) composites. The method involved (1) exfoliating graphite to prepare graphite intercalation compounds (GICs) using environment‐friendly ultrasonic energy and intercalating techniques, (2) preparing a high‐concentration GNS/CS dispersion from a mixture of GICs and CS, and (3) producing GNS/CS composites with varying GNS levels by adding the GNS/CS dispersion to CS. By incorporating 0.6 wt% GNS into a CS matrix, the mechanical and electrochemical properties of the resultant GNS/CS composite were markedly improved. Maximum enhancements of 29% and 39% in the elastic modulus and hardness of CS, respectively, were obtained. Furthermore, GNS/CS redox peak currents increased sevenfold relative to a CS‐modified electrode. POLYM. COMPOS., 39:4217–4223, 2018. © 2017 Society of Plastics Engineers
Zinc distribution in human prostate carcinoma cell line using synchrotron X‐ray microfluorescence
Authors: Rocha K.M.J. , Leitão R.G. , Oliveira‐Barros E.G. , Oliveira M.A. , Canellas C.G.L. , Anjos M.J. , Nasciutti L.E. , Lopes R.T. 
Published: July 2017

Cancer is a worldwide public health problem, and its incidence in the world grew by 20% in the last decade. Zinc, an essential trace element, is involved in many cellular processes. Concerning prostate cancer, Zn could inhibit the growth of tumor cells, by inducing cell cycle arrest or apoptosis. X‐ray microfluorescence (μXRF) is an elemental analysis technique that allows mapping biologically important elements at a submillimeter scale, with high sensitivity and negligible damage to the sample. In this study, we investigated cell viability through colorimetric cytotoxicity assay (MTT) and the behavior of human prostate cell lines obtained from normal (RWPE‐1) and tumorigenic (DU145) epithelium, in three‐dimensional spheroid cultures after supplementation with ZnCl2 for 24 and 48 hr using synchrotron μXRF. The measurements were performed at the Synchrotron Light National Laboratory (Campinas, Brazil). The results of μXRF showed that Zn intensity decreased in the DU145 tumor cells independent of supplementation or treatment time, and in normal cells, the intensity increased with supplementation and treatment time. The MTT assay results showed no significant differences, which indicates that the cell viability did not change. Our results indicate that μXRF can be used as an important tool to understand the mechanism of the loss of ability to capture zinc by prostate cancer cells. Copyright © 2017 John Wiley & Sons, Ltd.
Heterozygous carriers of succinyl‐CoA:3‐oxoacid CoA transferase deficiency can develop severe ketoacidosis
Authors: Sasai Hideo , Aoyama Yuka , Otsuka Hiroki , Abdelkreem Elsayed , Naiki Yasuhiro , Kubota Mitsuru , Sekine Yuji , Itoh Masatsune , Nakama Mina , Ohnishi Hidenori , Fujiki Ryoji , Ohara Osamu , Fukao Toshiyuki 
Published: July 2017

AbstractSuccinyl‐CoA:3‐oxoacid CoA transferase (SCOT, gene symbol OXCT1) deficiency is an autosomal recessive disorder in ketone body utilization that results in severe recurrent ketoacidotic episodes in infancy, including neonatal periods. More than 30 patients with this disorder have been reported and to our knowledge, their heterozygous parents and siblings have had no apparent ketoacidotic episodes. Over 5 years (2008–2012), we investigated several patients that presented with severe ketoacidosis and identified a heterozygous OXCT1 mutation in four of these cases (Case1 p.R281C, Case2 p.T435N, Case3 p.W213*, Case4 c.493delG). To confirm their heterozygous state, we performed a multiplex ligation‐dependent probe amplification analysis on the OXCT1 gene which excluded the presence of large deletions or insertions in another allele. A sequencing analysis of subcloned full‐length SCOT cDNA showed that wild‐type cDNA clones were present at reasonable rates to mutant cDNA clones. Over the following 2 years (2013–2014), we analyzed OXCT1 mutations in six more patients presenting with severe ketoacidosis (blood pH ≦7.25 and total ketone body ≧10 mmol/L) with non‐specific urinary organic acid profiles. Of these, a heterozygous OXCT1 mutation was found in two cases (Case5 p.G391D, Case6 p.R281C). Moreover, transient expression analysis revealed R281C and T435N mutants to be temperature‐sensitive. This characteristic may be important because most patients developed ketoacidosis during infections. Our data indicate that heterozygous carriers of OXCT1 mutations can develop severe ketoacidotic episodes in conjunction with ketogenic stresses.
Conservation and development in conflict: regeneration of wildDavidia involucrata(Nyssaceae) communities weakened by bamboo management in south-central China
Authors: Qian Shenhua , Tang Cindy Q. , Yi Sirong , Zhao Liang , Song Kun , Yang Yongchuan 
Published: July 2017

AbstractProtected areas, including nature reserves and management areas, are established for the conservation of biological diversity and protection of the associated natural and cultural resources. These objectives, however, are often in conflict with socio-economic development. We investigated the plant communities dominated by the dove treeDavidia involucratain a nature reserve on Mount Jinfo, China, where people intensively manage large areas of bamboo stands. We found a significant lack of small-sized main stems ofD.involucrata(0–25 cm diameter at breast height; height > 1.3 m) and newly emerging sprouts in the reserve. The height-class distribution showed a unimodal pattern, with most individuals (of bothD.involucrataand co-occurring species) concentrated in the 16–28 m height-class, and few individuals in the shrub and sub-canopy layer (1.3–8 m). Existing practices to facilitate the spread of bamboo stands, and the need to develop a local market for bamboo shoots received little consideration when the nature reserve was established in 1979 to protectD.involucrata. To conserveD. involucrataon Mount Jinfo the appropriate authorities and local parties involved in bamboo harvesting need to focus on methods that are favourable to the life history of this and other tree species, and strategies for their regeneration. These methods will also benefit the conservation of other highly valued trees that share similar life-history characteristics withD. involucrata.
Migration ofFasciola hepaticanewly excysted juveniles is inhibited by high-mannose and oligomannose-typeN-glycan-binding lectins
Authors: GARCIA-CAMPOS ANDRES , BAIRD ALAN W. , MULCAHY GRACE 
Published: July 2017

SUMMARYFasciola hepaticahas both zoonotic importance and high economic impact in livestock worldwide. After ingestion by the definitive host, the Newly Excysted Juveniles (NEJ) penetrate the intestine before reaching the peritoneal cavity. The role of some NEJ-derived proteins in invasion has been documented, but the role of NEJ glycans or lectin-binding receptors during initial infection in the gut is still unknown. To address these questions, the migration of NEJ through rat intestine was recorded at 30 min intervals up to 150 min by twoex vivomethods. Firstly, jejunal sheets were challenged with NEJ incubated with biotinylated lectins. Secondly, untreated NEJ were incubated with distal jejunum pre-treated with lectins. BothConcanavalin A(ConA) andGalanthus nivalis(GNL), which recognize mannose-typeN-glycans, significantly inhibited NEJ migration across the jejunum. Most of the lectins bound to the tegument and oral sucker of the NEJ, but only ConA and GNL maintained this interaction over 150 min. None of the lectins examined significantly reduced NEJ migration when pre-incubated with jejunal sheets, suggesting that host glycans might not be essential for initial binding/recognition of the gut by NEJ. Agents capable of blocking mannose-typeN-glycans on the NEJ tegument may have potential for disrupting infection.
Modeling the ultra-high intensity laser pulse – cone target interaction for ion acceleration at CETAL facility
Authors: Budrigă O. , D'Humières E. 
Published: July 2017

AbstractWe study the interaction of an ultra-high intensity laser pulse with plastic flat-top cone targets with curved walls and cone targets with straight walls. We find the appropriate type, dimensions of the cone target, and the ultra-high intensity laser pulse parameters for which the accelerated ions have the maximum energy and their number is the highest for a lower angular divergence and a better laser absorption. This numerical study will allow one to prepare and optimize first laser-ion acceleration experiments on CETAL using micro-cone targets.
Revision: review of non-elective hospitalisations of adults with CHD
Authors: Soufi Alexandra , Colman Jack M. , Li Qunyu , Oechslin Erwin N. , Kovacs Adrienne H. 
Published: July 2017

AbstractIntroductionThe adult CHD population is increasing and ageing and remains at high risk for morbidity and mortality. In a retrospective single-centre study, we conducted a comprehensive review of non-elective hospitalisations of adults with CHD and explored factors associated with length of stay.MethodsWe identified adults (⩾18 years) with CHD admitted during a 12-month period and managed by the adult CHD service. Data regarding demographics, cardiac history, hospital admission, resource utilisation, and length of stay were extracted.ResultsThere were 103 admissions of 91 patients (age 37±10 years; 52% female). Of 91 patients, 96% had moderate or complex defects. Of 103 admissions, 45% were through the emergency department. The most common reasons for admission were arrhythmia (37%) and heart failure (28%); 29% of admissions included a stay in the ICU. The mean number of consultations by other services was 2.0. Electrophysiology and anaesthesiology departments were most frequently consulted. After removing outliers, the mean length of stay was 7.9±7.4 days (median=5 days). The length of stay was longer for patients admitted for heart failure (12.2±10.3 days; p=0.001) and admitted directly to the ward (9.6±8.9 days; p=0.009).ConclusionsAmong non-electively hospitalised adults with CHD in a tertiary-care centre, management often entails an interdisciplinary approach, and the length of stay is longest for patients admitted with heart failure. The healthcare system must ensure optimal resources to maintain high-quality care for this expanding patient population.
Application of A Novel Three-dimensional Printing Genioplasty Template System and Its Clinical Validation: A Control Study
Authors: Li Biao , Wei Hongpu , Zeng Feini , Li Jianfu , Xia James J. , Wang Xudong 
Published: July 2017

AbstractThe purpose of this control study was to assess the accuracy and clinical validation of a novel genioplasty template system. Eighty-eight patients were enrolled and divided into 2 groups: experimental group (using genioplasty templates) and control group (without genioplasty templates). For the experimental group, the templates were designed based on computerized surgical plan and manufactured using three-dimensional printing technique. The template system included a cutting guide and a pair of repositioning guides. For the control group, traditional intraoperative measurements were used without genioplasty templates. The outcome evaluation was completed by comparing planned outcomes with postoperative outcomes. Linear and angular differences for the chin was measured and reported using root mean square deviation (RMSD) and the Bland-Altman method. All surgeries were successfully completed. There was no difficulty to use genioplasty templates. For the experimental group, the largest RMSDs were 1.1 mm in anteroposterior direction and 2.6° in pitch orientation. For the control group without templates, the largest RMSDs were 2.63 mm in superoinferior direction and 7.21° in pitch orientation. Our findings suggest that this genioplasty template system provides greater accuracy in repositioning the chin than traditional intraoperative measurements, and the computerized plan can be transferred accurately to the patient for genioplasty.
Antiangiogenic activity of phthalides-enriched Angelica Sinensis extract by suppressing WSB-1/pVHL/HIF-1α/VEGF signaling in bladder cancer
Authors: Chen Meng-Chuan , Hsu Wen-Lin , Chang Wen-Liang , Chou Tz-Chong 
Published: July 2017

AbstractThe hypoxia-inducible factor-1α (HIF-1α) plays a critical role in tumor angiogenesis. It has been reported that the acetone extract of Angelica sinensis (AE-AS) rich in phthalides is able to inhibit cancer cell proliferation. However, whether AE-AS reduces cancer angiogenesis remains unknown. In this study, we demonstrated that AE-AS significantly inhibited the angiogenesis in vitro and in vivo evidenced by attenuation of the tube formation in hypoxic human umbilical vascular endothelial cells (HUVECs), and the vasculature generation in Matrigel plug, the chicken chorioallantoic membrane, and tumors. Treatment with AE-AS markedly decreased the protein accumulation and transcriptional activity of HIF-1α, vascular endothelial growth factor (VEGF) expression/secretion, and VEGFR2 phosphorylation in hypoxic human bladder cancer (T24) cells and tumor tissues accompanied by a reduction of tumor growth. Notably, AE-AS-induced HIF-1α protein degradation may, at least partly, attribute to inhibition of WSB-1-dependent pVHL degradation. Moreover, VEGFR2-activated PI3K/AKT/mTOR signaling pathway in hypoxic T24 cells was greatly inhibited by AE-AS. Collectively, AE-AS may be a potential anticancer agent by attenuating cancer angiogenesis via suppression of WSB-1/pVHL/HIF-1α/VEGF/VEGFR2 cascade.