bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics of murta bast fiber reinforced epoxy composites
Authors: Hussain Barbhuiya Ajmal , Uddin Choudhury Saad , Ismail Kochi 
Published: July 2016

ABSTRACTThe growing global concern over environment protection has led to the application of natural fiber reinforced polymer composites as alternative materials in manufacturing sectors. Various natural fibers are therefore being explored for reinforcement of polymer matrices. In the present work, murta bast fibers of varying length and weight percent are mixed randomly with the epoxy matrix and the composites are prepared from these mixtures by using the hand lay‐up method. The composites are characterized on the basis of density, thermal gravimetric analysis, infrared spectroscopy, scanning electron microscopy, tensile strength, flexural strength, compressive strength, impact strength, and Rockwell hardness studies. Tensile, flexural, and compressive moduli of the composites are also determined. The tensile strength of the composite was analyzed in the light of the different analytical models. Composites containing 30 weight % fibers of length 25 or 35 mm have the optimum mechanical properties. Murta bast fiber has the characteristics to become a good natural material for reinforcement. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44142.
Economic implications of incorporating emission controls to mitigate air pollutants emitted from a modeled hydrocarbon‐fuel biorefinery in the United States
Authors: Bhatt Arpit , Zhang Yimin , Davis Ryan , Eberle Annika , Heath Garvin 
Published: July 2016

AbstractThe implementation of the US Renewable Fuel Standard is expected to increase the construction and operation of new biofuel facilities. Allowing this industry to grow without adversely affecting air quality is an important sustainability goal sought by multiple stakeholders. However, little is known about how the emission controls potentially required to comply with air quality regulations might impact biorefinery cost and deployment strategies such as siting and sizing. In this study, we use a baseline design for a lignocellulosic hydrocarbon biofuel production process to assess how the integration of emission controls impacts the minimum fuel selling price (MFSP) of the biofuel produced. We evaluate the change in MFSP for two cases as compared to the baseline design by incorporating (i) emission controls that ensure compliance with applicable federal air regulations and (ii) advanced control options that could be used to achieve potential best available control technology (BACT) emission limits. Our results indicate that compliance with federal air regulations can be achieved with minimal impact on biofuel cost (~$0.02 per gasoline gallon equivalent (GGE) higher than the baseline price of $5.10 GGE−1). However, if air emissions must be further reduced to meet potential BACT emission limits, the cost could increase nontrivially. For example, the MFSP could increase to $5.50 GGE−1 by adopting advanced emission controls to meet potential boiler BACT limits. Given tradeoffs among emission control costs, permitting requirements, and economies of scale, these results could help inform decisions about biorefinery siting and sizing and mitigate risks associated with air permitting. Published 2016. This article is a U.S. Government work and is in the public domain in the USA. Biofuels, Bioproducts and Biorefining published by Society of Industrial Chemistry and John Wiley & Sons Ltd.
Association of TIP30 expression and prognosis of hepatocellular carcinoma in patients with HBV infection
Authors: Zhang Xia , Lv Lizhi , Ouyang Xuenong , Zhang Shi'an , Fang Jian , Cai Lirong , Li Dongliang 
Published: July 2016

AbstractAltered expression of TIP30, a tumor suppressor, has been observed in many cancers. In this study, we have evaluated the expression of TIP30 in the tissues of 209 hepatocellular carcinomas (HCC) and their adjacent tissues by using a high‐density tissue microarray, and analyzed its correlation with the clinical pathological parameters of the patients. The results revealed negative or weak expression of TIP30 in 43.5% (91/209) of the HCC tissues, and in only 27% (56/209) of the adjacent tissues. The expression level of TIP30 in HCC was inversely correlated with serum alpha‐fetoprotein (AFP) levels, HBV infection, and tumor differentiation. Multivariate analysis for survival indicated that serum HBV infection was the most significant predictor of poor prognosis in HCC (P = 0.0023), and TIP30 expression and tumor differentiation were also independent indicators in this respect (P = 0.0364 and P = 0.0397, respectively). Patients with medium or high expression levels of TIP30 (TIP30++/+++) had a better 5‐year overall survival rate than those with low/negative (TIP30+/−) expression (P < 0.001). TIP30+/−/HBV+ patients had the worst 5‐year overall survival rate, whereas TIP30++/+++/HBV− patients had the best. To further explore the correlation between TIP30 and HBV infection in HCC, HBV+ hepatoblastoma cell‐line HepG2 2.2.15 and HCC cell‐line Hep3B were used. Upon silencing of HBV, we observed an upregulation of TIP30 and decreased cell proliferation. In the in vivo studies, we found that the mice inoculated with HepG2 2.2.15 cells with HBV silencing had a prolonged tumor latency and a longer life span, as compared to the control mice inoculated with untreated control cells. In conclusion, the results suggest that downregulation of TIP30 may result from HBV infection, and subsequently promotes the progression of HCC.
New schedule of bevacizumab/paclitaxel as first‐line therapy for metastatic HER2‐negative breast cancer in a real‐life setting
Authors: Cannita Katia , Paradisi Stefania , Cocciolone Valentina , Bafile Alberto , Rinaldi Lucia , Irelli Azzurra , Lanfiuti Baldi Paola , Zugaro Luigi , Manetta Rosa , Alesse Edoardo , Ricevuto Enrico , Ficorella Corrado 
Published: July 2016

AbstractAngiogenesis plays an essential role in the growth and progression of breast cancer. This observational single center study evaluated the efficacy and safety of a new weekly schedule of bevacizumab/paclitaxel combination in the first‐line treatment of unselected, HER2‐negative, metastatic breast cancer (MBC) patients, in a real‐life setting. Thirty‐five patients (median age 56 years, range 40–81) with HER2‐negative MBC were treated with paclitaxel (70 mg/m2) dd 1,8,15 q21 (60 mg/m2 if ≥65 years or secondary Cumulative Illness Rating Scale) plus bevacizumab (10 mg/kg) every 2 weeks. Twenty‐two patients (63%) had ≥2 metastatic sites and 15 (43%) visceral disease. Eleven patients (31%) had a triple‐negative breast cancer (TNBC). A clinical complete response (cCR) was observed in 6 (17%) cases after a median of seven cycles, a partial response (PR) in 22 (63%), and a stable disease (SD) in 6 (17%) cases; the overall clinical benefit rate was 97%. In TNBC subgroup, cCR occurred in 1 (9%) case, PR in 8 (73%), and SD in 2 (18%). At a median follow‐up of 13 months (range 1–79 months), the median progression‐free survival was 11 months and the median overall survival was 36 months. No grade 4 adverse events occurred. The main grade 3 toxicities observed were neutropenia (11.4%), hypertension (5.7%), stomatitis (2.8%), diarrhea (2.8%), and vomiting (2.8%). The administration of weekly paclitaxel plus bevacizumab in this real‐life experience shows similar efficacy than previously reported schedules, with a comparable dose intensity and a good toxicity profile.
Mechanisms of immune evasion and current status of checkpoint inhibitors in non‐small cell lung cancer
Authors: Qin Angel , Coffey David G. , Warren Edus H. , Ramnath Nithya 
Published: July 2016

AbstractIn the past several years, immunotherapy has emerged as a viable treatment option for patients with advanced non‐small cell lung cancer (NSCLC) without actionable driver mutations that have progressed on standard chemotherapy. We are also beginning to understand the methods of immune evasion employed by NSCLC which likely contribute to the 20% response rate to immunotherapy. It is also yet unclear what tumor or patient factors predict response to immunotherapy. The objectives of this review are (1) review the immunogenicity of NSCLC (2) describe the mechanisms of immune evasion (3) summarize efforts to target the anti‐program death‐1 (PD‐1) and anti‐program death‐ligand 1(PD‐L1) pathway (4) outline determinants of response to PD‐1/PD‐L1 therapy and (5) discuss potential future areas for research.
Spin Crossover in Nitrito‐Myoglobin as Revealed by Resonance Raman Spectroscopy
Authors: Lambrou Alexandra , Ioannou Androulla , Pinakoulaki Eftychia 
Published: July 2016

AbstractThe myoglobin (Mb) heme Fe‐O‐N=O and heme Fe‐O‐N=O/2‐nitrovinyl species have been characterized by resonance Raman spectroscopy. In the heme Fe‐O‐N=O species, the bound nitrite ligand is removed by solvent exchange, thus reforming metmyoglobin (metMb). The high‐spin heme Fe‐O‐N=O unit is converted into a low‐spin heme Fe‐O‐N=O/2‐nitrovinyl species that can be reversibly switched between a low‐ and a high‐spin state without removing the bound nitrite ligand, as observed in the case of the heme Fe‐O‐N=O species. This spin‐state change is likely to be accompanied by a general structural rearrangement in the protein‐binding pocket. This example is the first of a globin protein that can reversibly change its metal spin state through an internal perturbation. These findings provide a basis for understanding the structure–function relationship of the spin cross found in other metalloenzymes and FeIII–porphyrin complexes.
Adjuvant chemotherapy is associated with improved survival in patients with stage II colon cancer
Authors: Casadaban Leigh , Rauscher Garth , Aklilu Mebea , Villenes Dana , Freels Sally , Maker Ajay V. 
Published: July 2016

BACKGROUNDThe role of adjuvant chemotherapy in patients with stage II colon cancer remains to be elucidated and its use varies between patients and institutions. Currently, clinical guidelines suggest discussing adjuvant chemotherapy for patients with high‐risk stage II disease in the absence of conclusive randomized controlled trial data. To further investigate this relationship, the objective of the current study was to determine whether an association exists between overall survival (OS) and adjuvant chemotherapy in patients stratified by age and pathological risk features.METHODSData from the National Cancer Data Base were analyzed for demographics, tumor characteristics, management, and survival of patients with stage II colon cancer who were diagnosed from 1998 to 2006 with survival information through 2011. Pearson Chi‐square tests and binary logistic regression were used to analyze disease and demographic data. Survival analysis was performed with the log‐rank test and Cox proportional hazards regression modeling. Propensity score weighting was used to match cohorts.RESULTSAmong 153,110 patients with stage II colon cancer, predictors of receiving chemotherapy included age <65 years, male sex, nonwhite race, use of a community treatment facility, non‐Medicare insurance, and diagnosis before 2004. Improved and clinically relevant OS was associated with the receipt of adjuvant chemotherapy in all patient subgroups regardless of high‐risk tumor pathologic features (poor or undifferentiated histology, <12 lymph nodes evaluated, positive resection margins, or T4 histology), age, or chemotherapy regimen, even after adjustment for covariates and propensity score weighting (hazard ratio, 0.76; P<.001). There was no difference in survival noted between single and multiagent adjuvant chemotherapy regimens.CONCLUSIONSIn what to the authors' knowledge is the largest group of patients with stage II colon cancer evaluated to date, improved OS was found to be associated with adjuvant chemotherapy regardless of treatment regimen, patient age, or high‐risk pathologic risk features. Cancer 2016;122:3277–3287. © 2016 American Cancer Society.
Surface topography during neural stem cell differentiation regulates cell migration and cell morphology
Authors: Czeisler Catherine , Short Aaron , Nelson Tyler , Gygli Patrick , Ortiz Cristina , Catacutan Fay Patsy , Stocker Ben , Cronin James , Lannutti John , Winter Jessica , Otero José Javier 
Published: July 2016

ABSTRACTWe sought to determine the contribution of scaffold topography to the migration and morphology of neural stem cells by mimicking anatomical features of scaffolds found in vivo. We mimicked two types of central nervous system scaffolds encountered by neural stem cells during development in vitro by constructing different diameter electrospun polycaprolactone (PCL) fiber mats, a substrate that we have shown to be topographically similar to brain scaffolds. We compared the effects of large fibers (made to mimic blood vessel topography) with those of small‐diameter fibers (made to mimic radial glial process topography) on the migration and differentiation of neural stem cells. Neural stem cells showed differential migratory and morphological reactions with laminin in different topographical contexts. We demonstrate, for the first time, that neural stem cell biological responses to laminin are dependent on topographical context. Large‐fiber topography without laminin prevented cell migration, which was partially reversed by treatment with rock inhibitor. Cell morphology complexity assayed by fractal dimension was inhibited in nocodazole‐ and cytochalasin‐D–treated neural precursor cells in large‐fiber topography, but was not changed in small‐fiber topography with these inhibitors. These data indicate that cell morphology has different requirements on cytoskeletal proteins dependent on the topographical environment encountered by the cell. We propose that the physical structure of distinct scaffolds induces unique signaling cascades that regulate migration and morphology in embryonic neural precursor cells. J. Comp. Neurol. 524:3485–3502, 2016. © 2016 Wiley Periodicals, Inc.
Comprehensive cellular‐resolution atlas of the adult human brain
Authors: Ding Song‐Lin , Royall Joshua J. , Sunkin Susan M. , Ng Lydia , Facer Benjamin A.C. , Lesnar Phil , Guillozet‐Bongaarts Angie , McMurray Bergen , Szafer Aaron , Dolbeare Tim A. , Stevens Allison , Tirrell Lee , Benner Thomas , Caldejon Shiella , Dalley Rachel A. , Dee Nick , Lau Christopher , Nyhus Julie , Reding Melissa , Riley Zackery L. , Sandman David , Shen Elaine , van der Kouwe Andre , Varjabedian Ani , Write Michelle , Zollei Lilla , Dang Chinh , Knowles James A. , Koch Christof , Phillips John W. , Sestan Nenad , Wohnoutka Paul , Zielke H. Ronald , Hohmann John G. , Jones Allan R. , Bernard Amy , Hawrylycz Michael J. , Hof Patrick R. , Fischl Bruce , Lein Ed S. 
Published: July 2016

ABSTRACTDetailed anatomical understanding of the human brain is essential for unraveling its functional architecture, yet current reference atlases have major limitations such as lack of whole‐brain coverage, relatively low image resolution, and sparse structural annotation. We present the first digital human brain atlas to incorporate neuroimaging, high‐resolution histology, and chemoarchitecture across a complete adult female brain, consisting of magnetic resonance imaging (MRI), diffusion‐weighted imaging (DWI), and 1,356 large‐format cellular resolution (1 µm/pixel) Nissl and immunohistochemistry anatomical plates. The atlas is comprehensively annotated for 862 structures, including 117 white matter tracts and several novel cyto‐ and chemoarchitecturally defined structures, and these annotations were transferred onto the matching MRI dataset. Neocortical delineations were done for sulci, gyri, and modified Brodmann areas to link macroscopic anatomical and microscopic cytoarchitectural parcellations. Correlated neuroimaging and histological structural delineation allowed fine feature identification in MRI data and subsequent structural identification in MRI data from other brains. This interactive online digital atlas is integrated with existing Allen Institute for Brain Science gene expression atlases and is publicly accessible as a resource for the neuroscience community. J. Comp. Neurol. 524:3127–3481, 2016. © 2016 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.
Parkinsonian monkeys with prior levodopa‐induced dyskinesias followed by fetal dopamine precursor grafts do not display graft‐induced dyskinesias
Authors: Kordower Jeffrey H. , Vinuela Angel , Chu Yaping , Isacson Ole , Redmond D. Eugene 
Published: July 2016

ABSTRACTClinical trials testing the hypothesis that fetal dopamine grafts would provide antiparkinsonian benefit in patients who had already developed side effects from their long‐term use of L‐dopa revealed, in some cases, the presence of dyskinesias even in the absence of L‐dopa. The form, intensity, and frequency of these dyskinesias were quite variable, but their manifestation slowed the clinical development of cell replacement therapies. Rodent models of graft‐induced dyskinesias (GIDs) have been proposed, but their accuracy in modeling GIDs has been questioned because they usually require amphetamine for their presentation. The present study attempted to model GIDs in parkinsonian monkeys and, for the first time, to test the effect of grafts on previously dyskinetic monkeys. Toward this end, monkeys were rendered parkinsonian with n‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and dyskinetic with levodopa. They then received intraputamenal grafts of fetal dopaminergic cells, control cerebellar cells, or vehicle bilaterally and were studied for 18 months. Dopaminergic cells were grafted in a manner designed to produce either “hot spot” or “widespread” striatal innervation. Although levodopa‐induced dyskinesias could be elicited postoperatively, GIDs were never observed in any animal at any time after grafting. Grafted monkeys were also challenged with levodopa but did not show any greater responses to these challenges than before grafting. These studies support the development of future dopamine neuron cell transplantation therapy‐based approaches, indicating that in relevant primate models with appropriate cell preparation methodology, with successful graft survival and putamenal dopamine innervation, there is no evidence of graft‐induced dyskinesias. J. Comp. Neurol. 525:498–512, 2017. © 2016 Wiley Periodicals, Inc.
Facile Synthesis of BaTiO3 Nanocubes with the Use of Anatase TiO2 Nanorods as a Precursor to Titanium Hydroxide
Authors: Vara Madeline , Chi Miaofang , Xia Younan 
Published: July 2016

AbstractWe report a solvothermal method for the facile and reproducible synthesis of BaTiO3 nanocubes by employing anatase TiO2 nanorods as a precursor to titanium hydroxide. The TiO2 nanorods were, in turn, synthesized in advance through another solvothermal process. We could obtain high‐quality BaTiO3 nanocubes by reacting the TiO2 nanorods with Ba(NO3)2 under solvothermal conditions in the presence of oleic acid and acetic acid as dual capping agents, followed by a purification process involving chemical washing and physical filtration. The addition of acetic acid alongside oleic acid was critical to the formation of well‐defined {100} facets on the nanocrystals and also increased batch‐to‐batch reproducibility without the use of a glove box or similar air‐free experimental design. Using this method, BaTiO3 nanocubes crystallized in the cubic phase could be readily obtained with an average edge length around 8 nm.
Lack of sex‐specific movement patterns in an alien species at its invasion front – consequences for invasion speed
Authors: Herfindal Ivar , Melis Claudia , Åhlén Per‐Arne , Dahl Fredrik 
Published: July 2016

SummaryEfficient targeting of actions to reduce the spread of invasive alien species relies on understanding the spatial, temporal, and individual variation of movement, in particular related to dispersal. Such patterns may differ between individuals at the invasion front compared to individuals in established and dense populations due to differences in environmental and ecological conditions such as abundance of conspecifics or sex‐specific dispersal affecting the encounter rate of potential mates. We assessed seasonal and diurnal variation in movement pattern (step length and turning angle) of adult male and female raccoon dog at their invasion front in northern Sweden using data from Global Positioning System (GPS)‐marked adult individuals and assessed whether male and female raccoon dog differed in their movement behavior. There were few consistent sex differences in movement. The rate of dispersal was rather similar over the months, suggesting that both male and female raccoon dog disperse during most of the year, but with higher speed during spring and summer. There were diurnal movement patterns in both sexes with more directional and faster movement during the dark hours. However, the short summer nights may limit such movement patterns, and long‐distance displacement was best explained by fine‐scale movement patterns from 18:00 to 05:00, rather than by movement patterns only from twilight and night. Simulation of dispersing raccoon dogs suggested a higher frequency of male–female encounters that were further away from the source population for the empirical data compared to a scenario with sex differences in movement pattern. The lack of sex differences in movement pattern at the invasion front results in an increased likelihood for reproductive events far from the source population. Animals outside the source population should be considered potential reproducing individuals, and a high effort to capture such individuals is needed throughout the year to prevent further spread.
Evolution of alternative insect life histories in stochastic seasonal environments
Authors: Kivelä Sami M. , Välimäki Panu , Gotthard Karl 
Published: July 2016

AbstractDeterministic seasonality can explain the evolution of alternative life history phenotypes (i.e., life history polyphenism) expressed in different generations emerging within the same year. However, the influence of stochastic variation on the expression of such life history polyphenisms in seasonal environments is insufficiently understood. Here, we use insects as a model and explore (1) the effects of stochastic variation in seasonality and (2) the life cycle on the degree of life history differentiation among the alternative developmental pathways of direct development and diapause (overwintering), and (3) the evolution of phenology. With numerical simulation, we determine the values of development (growth) time, growth rate, body size, reproductive effort, adult life span, and fecundity in both the overwintering and directly developing generations that maximize geometric mean fitness. The results suggest that natural selection favors the expression of alternative life histories in the alternative developmental pathways even when there is stochastic variation in seasonality, but that trait differentiation is affected by the developmental stage that overwinters. Increasing environmental unpredictability induced a switch to a bet‐hedging type of life history strategy, which is consistent with general life history theory. Bet‐hedging appeared in our study system as reduced expression of the direct development phenotype, with associated changes in life history phenotypes, because the fitness value of direct development is highly variable in uncertain environments. Our main result is that seasonality itself is a key factor promoting the evolution of seasonally polyphenic life histories but that environmental stochasticity may modulate the expression of life history phenotypes.