bluuebunny/crossref_metadata_2025_split huggingface dataset:
Telemedicine inside the Pocket: The Impact of Smartphones on Daily Patients’ Evaluations
Authors: Nasr Adonis , Abreu-Reis Phillipe , Bassani Tayron , Collaco Iwan A , Pereira Guilherme D , Faggion Heloisa Z , Sawczyn Guilherme V , Uchida Erick P , Tomasich Flavio S , Lopes Juliano A 
Published: October 2016

ABSTRACT

Objective
To evaluate the perception of doctors, residents, and medical students of smartphone use on daily medical practice.

Materials and methods
Cross-sectional study with data collected online by questionnaire on Google Docs®, with closed multiple-choice questions regarding smartphones use in medical practice and its impact on decision-making and patients' privacy.

Results
There were 118 questionnaires, mostly from students (61%), followed by medical residents (31%) and medical preceptors (8%). All preceptors confirmed eventual use of smartphones on clinical cases discussions, 77.8% of whom use it in less than half of the time. Among the residents, 94.6% use theirs smartphones, 77% of them in more than half of the time. On the contrary, 12.5% of the students do not use this kind of resource, and among those that do use it, 50% do so more than half of the time. All preceptors, 94.6% residents and 80.6% of the students believe its use does not expose the patients' privacy.

Conclusion
Preceptors and residents use smartphones more often than medical students. Most agree its use helps on daily decision-making and does not jeopardize the patients' privacy.

How to cite this article
Abreu-Reis P, Bassani T, Collaco IA, Pereira GD, Faggion HZ, Sawczyn GV, Uchida EP, Nasr A, Tomasich FS, Lopes JA. Telemedicine inside the Pocket: The Impact of Smartphones on Daily Patients' Evaluations. Panam J Trauma Crit Care Emerg Surg 2016;5(2):88-92.
Subacute Subdural Hematoma mimicking Epidural Hematoma in Infant Patient
Authors: Faried Ahmad , Arifin Muhammad Z , Wirjomartani Benny A 
Published: October 2016

ABSTRACT
Subacute subdural hematoma (SDH) is one of the most common clinical entities encountered in daily neurosurgical practice. The imaging of computed tomography (CT) has made a major impact on the diagnosis of subacute SDH. Although unilateral chronic lesion of SDH as a result of a space-occupying lesion is usually easily recognizable on CT scan, subacute SDH appearing in lenticular form may cause considerable difficulty, particularly when its appearance mimics the classic CT scan appearance of an epidural hematoma (EDH). Pathognomonic findings on CT scan are usually sufficient to establish a correct diagnosis, though the presence of such appearance can also be a misleading finding, especially in an infant patient.

How to cite this article
Yudoyono F, Faried A, Wirjomartani BA, Arifin MZ. Subacute Subdural Hematoma mimicking Epidural Hematoma in Infant Patient. Panam J Trauma Crit Care Emerg Surg 2016;5(2):113-115.
Effect of Different substrate Disinfection Methods on the Production of Pleurotus ostreatus
Authors: Atila Funda 
Published: October 2016

AbstractThe aim of this paper is to estimate which of disinfection method is more effective in case of higher yield and fewer cost in cultivation of Pleurotus ostreatus in rural areas. For this purpose, four different treatments; scalping in hot water (60, 80 and 100°C), and chemical disinfection (1% formaldehyde) were compared with sterilization by autoclave. It has been noticed that method of disinfection affects mycelium growing duration(day), yield(g/kg), biological efficiency (BE%), avarage weight of fruitbody(g), diameter of pileus(cm), stipe lenght(cm) and width(cm). P. ostreatus took significantly much time to colonise the substrate (19.9 days) disinfected by chemical disinfection compared with others. Chemical disinfection (271.28 g/kg and 91.96%) and scalding hot water at 80oC (263.42 g/kg and 90.83%) had highest productivity in terms of yield and BE, respectively, while scalding hot water at 60oC (136.08 g/kg and 46.92%) had least productivity. The largest diameter of fruitbody was obtained by scalding in hot water at 80oC, while the longest stipes were harvested in disinfected substrate by chemicals. In conclusion, cheaper and more easily applecable scalping in hot water 80°C and chemical disinfection may be use for the disinfection of growing substrates instead of sterilization with autoclave in rural areas.Keywords: mushroom growing substrate, disinfection methods, autoclaved, scalding, chemical disinfection, Pleurotus ostreatus
Thrombocyte Aggregative Activity of Irshire Breed Calves of Milk Nutrition
Authors: Nikolayevich Medvedev Ilya 
Published: October 2016

Evaluation of blood indices and especially hemostasis elements of productive cattle has great practical meaning for biology. They are closely connected with their somatic characteristics and functioning processes of the whole organism. Clarification of their values allows to work out age-specific norms of given indices and to define clearly the beginning of hemostasiopathy coming. High productivity of Irshire cattle and great meaning of thrombocyte activity of its cubs enduced to make evaluation of blood platelets aggregation. The aim of the work: to define peculiarities of thrombocyte activity of Irshire breed healthy calves during milk nutrition phase. There was fulfilled the investigation of 65 milk nutrition calves of Irshire breed with the usage of hematological research methods. The most active thrombocyte aggregation was noted for adenosine diphosfate being maximum to the end of investigation. Collagenous and rhystomitzine aggregation had less intensity and similar direction what indirectly pointed at not high collagen availability and not large Willybrand’s factor concentration in it. Deaggregative thrombocyte capabilities in response to all the used inductors in case of Irshire calves of milk nutrition had tendency to growth. Not high thrombocyte activity provides cattle of this breed during growth and development optimal conditions for blood supply of growing and ripening organs.
RISCO DE ÚLCERAS DE MEMBROS INFERIORES NOS DIABÉTICOS DE UM AMBULATÓRIO UNIVERSITÁRIO
Authors: Pires Micali Ana Carolina , Ravazzani Ana , De Lemos Daniele , Santos Luiza D. E. , Guerra Maria I. M. 
Published: October 2016

OBJETIVO: Estratificar o risco de ulceração de membros inferiores em pacientes diabéticos tipo 2 do Ambulatório de Endocrinologia da Santa Casa de Misericóidia de Curitiba – PR. MÉTODO: A amostra foi composta por 100 pacientes diabéticos e maiores de 18 anos, submetidos a um questionário e ao exame físico dos pés, para a verificação de Fatores de Risco para ulceração, Presença de Sinais e Sintomas Neuropáticos, verificação de Perda da Sensibilidade Protetora (PSP) e Doença Arterial Periférica (DAP). A partir destes dados, calculou-se a estratificação do risco de ulceração e avaliou-se a correlação das variáveis sexo, idade, tempo de doença, tipo de terapia, presença de outras complicações crônicas e controle do diabetes (DM) com esta estratificação de risco. RESULTADOS: 26% dos pacientes apresentaram PSP e 63% risco de DAP. Além disso, 15% apresentaram risco 3 (alto risco) e 23 % risco 2 (risco moderado). Houve correlação positiva entre a estratificação do risco e a presença de outras complicações crônicas do DM (p=0,003) e maior tempo médio de doença (p=0,009). CONCLUSÃO: 38% foram classificados como risco 2 e 3 para ulceração de membros inferiores (alto risco). Houve uma correlação entre a classificação de risco do pé diabético e as variáveis tempo médio de DM e complicações crônicas do DM, o que sugere a necessidade de acompanhamento desta população. O exame dos pés faz-se necessário para quantificar o risco de úlceras de membros inferiores em pacientes diabéticos sintomáticos ou não, a fim de melhorar as estratégias de tratamento e prevenção desta complicação.
Delta-9-tetrahydrocannabinol and cannabidiol: Separating the chemicals from the “weed,” a pharmacodynamic discussion
Authors: Boggs Douglas Lee , Peckham Alyssa , Boggs Angela A. , Ranganathan Mohini 
Published: October 2016

Abstract
Cannabis is being increasingly used as a medical treatment for a variety of illnesses. However, the cannabis plant has more than 70 different phytocannabinoids with potential pharmacologic activity. Two of the most researched phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Evidence suggests CBD can decrease some of the psychomimetic effects of THC. This has led to the development of a new drug, Nabiximols, for the treatment of moderate to severe spasticity due to multiple sclerosis. A discussion of evidence supporting proposed pharmacodynamic interplay between CBD and THC is presented.
Medical mimics: Differential diagnostic considerations for psychiatric symptoms
Authors: McKee Jerry , Brahm Nancy 
Published: October 2016

AbstractPatients with underlying medical disease can present to the health care system with psychiatric symptoms predominating. Identification of an underlying medical condition masquerading as a psychiatric disorder can be challenging for clinicians, especially in patients with an existing psychiatric condition. The term medical mimic or secondary psychosis has been used to describe this clinical situation. Diagnostic categories from The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, that may encompass medical mimics include substance-induced disorders, which includes medications, and unspecified mental disorder due to another medical condition in situations where the clinician may lack needed information for a complete diagnosis. At this time, there is no single diagnostic test or procedure available to differentiate primary versus secondary psychosis on the basis of psychopathology presentation alone. When considering a diagnosis, clinicians should evaluate for the presence of atypical features uncharacteristic of the psychiatric symptoms observed; this may include changes in functionality and/or age of onset and symptom presentation severity. The purpose of this work is to provide a structured clinical framework for evaluation for medical mimics, identify groups considered to be at highest risk for medical mimics, and present common syndromic features suggestive of a medical mimic. Selected case scenarios are used to illustrate key concepts for evaluating and assessing a patient presenting with acute psychiatric symptomatology to improve judgment in ruling out potential medical causality.
Acute psychosis secondary to suspected hyperparathyroidism: A case report and literature review
Authors: Park Sinae , Hieber Robin 
Published: October 2016

Abstract

Introduction:
Hyperparathyroidism begins as a benign disease that is often left undetected unless the patient presents with severe symptoms. Often, the first sign of hyperparathyroidism is elevation in serum calcium.

Case Description:
A 38-year-old man presented with new onset acute psychosis. Laboratory testing revealed co-occurring untreated hyperparathyroidism.

Discussion:
A literature search was performed using PubMed to identify articles published in English with the following key terms: “hyperparathyroidism,” “psychosis,” and “hypercalcemia.” A review of findings follows the case report. Despite a thorough literature review, any pathophysiological explanation for psychiatric manifestations of hyperparathyroidism remains hypothetical.
Biomarker‐Based Clinical Trial Design in the Era of Genomic Medicine
Authors: Simon Richard , Piccart‐Gebhart Martine 
Published: October 2016

Overview
The increasingly recognized molecular heterogeneity of human cancers together with the growing availability of powerful tools providing “molecular portraits” of this heterogeneity require the development of new paradigms for the development of a reliable basis for “personalized” medicine. We review new approaches to the design and analysis of clinical trials for the development of “targeted” therapeutics and diagnostics to inform their use.
Ein wiederverwendbarer Cobaltkatalysator für die selektive Hydrierung von funktionalisierten Nitroarenen und die direkte Synthese von Iminen und Benzimidazolen aus Nitroarenen und Aldehyden
Authors: Schwob Tobias , Kempe Rhett 
Published: October 2016

AbstractDie Nutzung von in großen Mengen verfügbaren Übergangsmetallen in Reaktionen, die bevorzugt von seltenen Edelmetallen vermittelt werden, wie beispielsweise Hydrierungen, ist eine erstrebenswerte Zielstellung in der Katalyse und eine attraktive Strategie zur Ressourcenschonung. Die Beobachtung neuer Selektivitätsmuster mit solchen preiswerten Metallkatalysatoren ist besonders ansprechend. Wir berichten hier über einen robusten und wiederverwendbaren Cobaltkatalysator, der die selektive Hydrierung von Nitroarenen in Gegenwart von hydrieranfälligen funktionellen Gruppen erlaubt, sowie über die direkte Synthese von Iminen aus Nitroarenen und Aldehyden bzw. Ketonen in Gegenwart solcher Substituenten. Weiterhin stellen wir die erste durch ein 3d‐Metall vermittelte direkte Synthese von Benzimidazolen aus Nitroarenen und Aldehyden vor. Funktionelle Gruppen, die leicht hydriert werden, werden auch hier toleriert.
Benign‐by‐Design Solventless Mechanochemical Synthesis of Three‐, Two‐, and One‐Dimensional Hybrid Perovskites
Authors: Jodlowski Alexander D. , Yépez Alfonso , Luque Rafael , Camacho Luis , de Miguel Gustavo 
Published: October 2016

AbstractOrganic–inorganic hybrid perovskites have attracted significant attention owing to their extraordinary optoelectronic properties with applications in the fields of solar energy, lighting, photodetectors, and lasers. The rational design of these hybrid materials is a key factor in the optimization of their performance in perovskite‐based devices. Herein, a mechanochemical approach is proposed as a highly efficient, simple, and reproducible method for the preparation of four types of hybrid perovskites, which were obtained in large amounts as polycrystalline powders with high purity and excellent optoelectronics properties. Two archetypal three‐dimensional (3D) perovskites (MAPbI3 and FAPbI3) were synthesized, together with a bidimensional (2D) perovskite (Gua2PbI4) and a “double‐chain” one‐dimensional (1D) perovskite (GuaPbI3), whose structure was elucidated by X‐ray diffraction.
A Dynamic and Responsive Host in Action: Light‐Controlled Molecular Encapsulation
Authors: Ryan Seán T. J. , del Barrio Jesús , Suardíaz Reynier , Ryan Daniel F. , Rosta Edina , Scherman Oren A. 
Published: October 2016

AbstractThe rational design of a flexible molecular box, oAzoBox4+, incoporating both photochromic and supramolecular recognition motifs is described. We exploit the E↔Z photoisomerization properties of azobenzenes to alter the shape of the cavity of the macrocycle upon absorption of light. Imidazolium motifs are used as hydrogen‐bonding donor components, allowing for sequestration of small molecule guests in acetonitrile. Upon E→Z photoisomerization of oAzoBox4+ the guest is expelled from the macrocyclic cavity.
A Reusable Co Catalyst for the Selective Hydrogenation of Functionalized Nitroarenes and the Direct Synthesis of Imines and Benzimidazoles from Nitroarenes and Aldehydes
Authors: Schwob Tobias , Kempe Rhett 
Published: October 2016

AbstractThe use of abundantly available transition metals in reactions that have been preferentially mediated by rare noble metals, for example, hydrogenations, is a desirable aim in catalysis and an attractive strategy for element conservation. The observation of novel selectivity patterns with such inexpensive metal catalysts is especially appealing. Herein, we report a novel, robust, and reusable cobalt catalyst that permits the selective hydrogenation of nitroarenes in the presence of highly hydrogenation‐sensitive functional groups, as well as the direct synthesis of imines from nitroarenes and aldehydes or ketones in the presence of such substituents. Furthermore, we introduce the first base‐metal‐mediated direct synthesis of benzimidazoles from nitroarenes and aldehydes. Functional groups that are easy to hydrogenate are again well tolerated.
Cover Image, Volume 10, Issue 6
Authors: Ssegane Herbert , Zumpf Colleen , Cristina Negri M. , Campbell Patty , Heavey Justin P. , Volk Timothy A. 
Published: October 2016

The cover image, by Maria Cristina Negri et al., is based on the Modeling and Analysis The economics of growing shrub willow as a bioenergy buffer on agricultural fields: A case study in the Midwest Corn Belt, DOI: 10.1002/bbb.1679.
image
Metal–Organic Framework Derived Carbon Nanotube Grafted Cobalt/Carbon Polyhedra Grown on Nickel Foam: An Efficient 3D Electrode for Full Water Splitting
Authors: Aijaz Arshad , Masa Justus , Rösler Christoph , Xia Wei , Weide Philipp , Fischer Roland A. , Schuhmann Wolfgang , Muhler Martin 
Published: October 2016

AbstractThe growth of metal–organic framework (ZIF‐67) nanocrystals on nickel foam (NF), followed by carbonization in diluted H2, leads to a nitrogen‐doped carbon‐nanotube‐grafted cobalt/carbon polyhedra film on NF. The obtained material serves as a highly active binder‐free electrocatalyst for both the oxygen evolution reaction (OER) and the hydrogen evolution reaction (HER), enabling high‐performance alkaline (0.1 m KOH) water electrolysis with potentials of 1.62 and 0.24 V, respectively, at OER and HER current densities of 10 mA cm−2.
Preparation of Functional Alternating Polymer Brushes and Their Orthogonal Surface Modification through Microcontact Printing
Authors: Buhl Moritz , Tesch Matthias , Lamping Sebastian , Moratz Johanna , Studer Armido , Ravoo Bart Jan 
Published: October 2016

AbstractThis paper reports microcontact printing (μCP) to immobilize an alkoxyamine initiator (regulator) on glass and silicon substrates and subsequent surface‐initiated alternating nitroxide‐mediated copolymerization (siNMP) of hexafluoroisopropyl acrylate (HFIPA) and 7‐octenylvinyl ether (OVE). The resulting patterned polymer brushes are analyzed by using atomic force microscopy (AFM). In addition, site‐specific post‐functionalization of the alternating polymer brushes by applying two orthogonal surface reactions is achieved with thiols and amines through μCP. The versatility of this post‐polymerization modification approach is demonstrated by site‐selective immobilization of small organic molecules, fluorophores, and ligands providing a binary bioactive surface. The successful side‐by‐side orthogonal immobilization is verified by using X‐ray photoelectron spectroscopy (XPS) and fluorescence microscopy.
Total Synthesis of Dansylated Park's Nucleotide for High‐Throughput MraY Assays
Authors: Wohnig Stephanie , Spork Anatol P. , Koppermann Stefan , Mieskes Gottfried , Gisch Nicolas , Jahn Reinhard , Ducho Christian 
Published: October 2016

AbstractThe membrane protein translocase I (MraY) is a key enzyme in bacterial peptidoglycan biosynthesis. It is therefore frequently discussed as a target for the development of novel antibiotics. The screening of compound libraries for the identification of MraY inhibitors is enabled by an established fluorescence‐based MraY assay. However, this assay requires a dansylated derivative of the bacterial biosynthetic intermediate Park's nucleotide as the MraY substrate. Isolation of Park's nucleotide from bacteria and subsequent dansylation only furnishes limited amounts of this substrate, thus hampering the high‐throughput screening for MraY inhibitors. Accordingly, the efficient provision of dansylated Park's nucleotide is a major bottleneck in the exploration of this promising drug target. In this work, we present the first total synthesis of dansylated Park's nucleotide, affording an unprecedented amount of the target compound for high‐throughput MraY assays.
Expedient and Diastereodivergent Assembly of Terpenoid Decalin Subunits having Quaternary Stereocenters through Organocatalytic Robinson Annulation of Nazarov Reagent
Authors: Berkes Barbara , Ozsváth Kristóf , Molnár Laura , Gáti Tamás , Holczbauer Tamás , Kardos György , Soós Tibor 
Published: October 2016

AbstractWe report an expedient approach to highly functionalized cis‐ and trans‐decalines that could function as key structural subunits toward the synthesis of various classes of terpenoids. Key to the strategy is an organocatalyzed Robinson annulation reaction of the Nazarov reagent that affords chiral enone building blocks with high enantioselectivities. The quaternary carbon stereogenic center can direct the subsequent reactions and allow the rapid and diastereoconvergent assembly of complex decalines with contiguous stereocenters.
Three Short Stories about Hexaarylbenzene–Porphyrin Scaffolds
Authors: Lungerich Dominik , Hitzenberger Jakob F. , Donaubauer Wolfgang , Drewello Thomas , Jux Norbert 
Published: October 2016

AbstractInvited for the cover of this issue are the groups of Thomas Drewello and Norbert Jux at the University Friedrich‐Alexander in Erlangen. The image depicts hexaarylbenzene‐porphyrin conjugates as fascinating functional dyes. Read the full text of the article at 10.1002/chem.201603789.
Divergent Chemoenzymatic Synthesis of Asymmetrical‐Core‐Fucosylated and Core‐Unmodified N‐Glycans
Authors: Li Tiehai , Huang Min , Liu Lin , Wang Shuo , Moremen Kelley W. , Boons Geert‐Jan 
Published: October 2016

AbstractA divergent chemoenzymaytic approach for the preparation of core‐fucosylated and core‐unmodified asymmetrical N‐glycans from a common advances precursor is described. An undecasaccharide was synthesized by sequential chemical glycosylations of an orthogonally protected core fucosylated hexasaccharide that is common to all mammalian core fucosylated N‐glycans. Antennae‐selective enzymatic extension of the undecasaccharide using a panel of glycosyl transferases afforded core fucosylated asymmetrical triantennary N‐glycan isomers, which are potential biomarkers for breast cancer. A unique aspect of our approach is that a fucosidase (FucA1) has been identified that selectively can cleave a core‐fucoside without affecting the fucoside of a sialyl LewisX epitope to give easy access to core‐unmodified compounds.
The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies
Authors: Haydl Alexander M. , Breit Bernhard 
Published: October 2016

AbstractHere, a concise and highly convergent synthesis of epothilone D was investigated, relying on fragments of equal complexity that could be prepared in gram scale quantities. The strategy to construct the fragments includes the use of a previously reported enantiospecific zinc‐catalyzed cross‐coupling of an α‐hydroxy ester triflate with a Grignard reagent, the application of a hydroboration/boron–magnesium exchange sequence for the rapid construction of the Z‐substituted trisubstituted double bond present in the natural product, and a Noyori‐type hydrogenation to install the β‐hydroxy ester moiety of the southern part. The key to success is the diastereoselective head‐to‐tail macrolactonization by an intramolecular addition of the corresponding ω‐alkynyl‐substituted carboxylic acids to construct a new stereocenter in the macrocyclic core structure in one single step.
Highly enantioselective Michael addition of cyclohexanone to nitroolefins catalyzed by pyrrolidine‐based bifunctional benzoylthiourea in water
Authors: Wang Zhen‐Yu , Ban Shu‐Rong , Yang Meng‐Chen , Li Qing‐Shan 
Published: October 2016

AbstractOrganocatalysis and aqueous reactions are identified as the focus of the greening of chemistry. Combining these two strategies effectively remains an interesting challenge in organic synthesis. Herein, we used pyrrolidine‐based benzoylthiourea1cto catalyze the asymmetric Michael addition of cyclohexanone to various nitroolefins in water to afford the corresponding compounds in moderate to good yields, and with excellent diastereoselectivities (up to >99:1 dr) and enantioselectivities (up to 99% ee).