bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oral Everolimus Following Dilation in Idiopathic Subglottic Stenosis
Authors: So Raymond J. , Collins Samuel L. , Collins Sarah , Mafla Laura , Chan-Li Yee , Lina Ioan , Gelbard Alexander , Motz Kevin M. , Hillel Alexander T. 
Published: September 2024

ImportanceCurrent medical therapies in idiopathic subglottic stenosis (iSGS) are insufficient in preventing the development and progression of scar tissue. An inhibitor of mammalian target of rapamycin, everolimus is an immunosuppressive medication shown to be effective in reducing fibrosis across a variety of fibroproliferative disorders, including preclinical models of iSGS.ObjectiveTo evaluate the effect of oral everolimus on postoperative recurrence of stenosis in iSGS.Design, Setting, and ParticipantsThis open-label, single-arm, phase 1, nonrandomized clinical trial analyzed 7 perimenopausal participants diagnosed with iSGS and followed-up at a tertiary care academic center for 6 months after dilation surgery. The trial was conducted from November 1, 2022, through May 15, 2024.InterventionParticipants took a 1.5-mg daily oral dose of everolimus for 42 days after surgery.Main outcomes and measuresThe primary outcome measure was safety as determined by adverse events. Secondary outcome measures included change in peak expiratory flow from baseline through 180 days after surgery; change in the luminal area, measured by computed tomographic (CT) scan, from the 14th and the 180th day; and changes in quality-of-life scores.ResultsOf the 8 perimenopausal participants, 7 (median age, 50 years [IQR, 45.0-52.5 years]) completed the study. Compared with baseline at all time points, there was an increase in peak expiratory flow. The median difference in liters per minute was 125 (95% CI, 90-270) on day 7 after surgery; 150 (95% CI, 110-290) on day 14; 138 (95% CI, 116-280) on day 28; 160 (95% CI, 100-270) on day 42; 155 (95% CI, 110-270) on day 60; 140 (95% CI, 100-270) on day 90; and 100 (95% CI, 20-240) on day 180. A decrease in the CT luminal area was observed from the day-14 measure to the day-180 measure (median stenosis, 7.2%; IQR, 1.9%-15.4%). During the trial, 1 participant (14.3%) each developed oral ulcers, a urinary tract infection, and a skin infection.Conclusions and RelevanceIn this interventional nonrandomized clinical trial of iSGS, adjuvant everolimus was well-tolerated with minor adverse events. Participants sustained postdilation peak expiratory flow for 13 weeks. These results support proceeding to a phase 2 trial to study drug efficacy and a more detailed investigation of adverse effects.Trial RegistrationClinicalTrials.gov Identifier: NCT05153668
Ultra‐Soft Liquid‐Ferrofluid Interfaces
Authors: Dev Arvind Arun , Hermans Thomas M. , Doudin Bernard 
Published: September 2024

AbstractSoft interfaces are ubiquitous in nature, governing quintessential hydrodynamics functions, like lubrication, stability, and cargo transport. It is shown here how a magnetic pressure at a magnetic–nonmagnetic fluid interface results in an ultra‐soft interface with nonlinear elasticity and tunable viscous shear properties. The balance between magnetic pressure, viscous stress, and Laplace pressure results in a deformed and stable liquid‐in‐liquid tube with apparent elasticity in the range of 2–10 kPa, possibly extended by a proper choice of liquid properties. Such highly deformable liquid–liquid interfaces of arbitrary shape with vanishing viscous shear open doors to unique microfluidic phenomena, biomaterial flows and complex biosystems mimicking.
Human Serum Albumin‐Coated 10B Enriched Carbon Dots as Targeted “Pilot Light” for Boron Neutron Capture Therapy
Authors: Zhong Tianyuan , Yang Yongjin , Pang Miao , Pan Yong , Jing Shiwei , Qi Yanxin , Huang Yubin 
Published: September 2024

AbstractBoron neutron capture therapy (BNCT) is a physiologically focused radiation therapy that relies on nuclear capture and fission processes. BNCT is regarded as one of the most promising treatments due to its excellent accuracy, short duration of therapy, and low side effects. The creation of novel boron medicines with high selectivity, ease of delivery, and high boron‐effective load is a current research topic. Herein, boron‐containing carbon dots (BCDs) and their human serum albumin (HSA) complexes (BCDs‐HSA) are designed and synthesized as boron‐containing drugs for BNCT. BCDs (10B: 7.1 wt%) and BCDs‐HSA exhibited excitation‐independent orange fluorescent emission which supported the use of fluorescence imaging for tracking 10B in vivo. The introduction of HSA enabled BCDs‐HSA to exhibit good biocompatibility and increased tumor accumulation. The active and passive targeting abilities of BCDs‐HSA are explored in detail. Subcutaneous RM‐1 tumors and B16‐F10 tumors both significantly decrease with BNCT, which consists of injecting BCDs‐HSA and then irradiating the area with neutrons. In short, this study provides a novel strategy for the delivery of boron and may broaden the perspectives for the design of boron‐containing carbon dots nanomedicine for BNCT.
Understanding Boron Chemistry as the Surface Modification and Electrolyte Additive for Co‐Free Lithium‐Rich Layered Oxide
Authors: Park Na Ri , Zhang Minghao , Han Bing , Li Weikang , Qian Kun , Nguyen HongNam , Kumakura Shinichi , Meng Ying Shirley 
Published: September 2024

AbstractLithium‐rich layered oxide (LRLO) stands out as a highly promising cathode material for the next generation of Li‐ion batteries, owing to its exceptional lithium storage capacity. The absence of cobalt in LRLO's composition provides an additional advantage, enabling cost‐effective production and thereby improving the feasibility of large‐scale manufacturing. Despite these promising attributes, LRLO has encountered challenges related to poor cycling performance and severe voltage decay, impeding its practical application. In addressing these challenges, a surface modification technique involving lithium borate (LBO) is employed through a dry coating method. The LBO‐coated LRLO exhibits a uniform surface layer with a thickness of 15 nm. Furthermore, the performance of LBO‐coated LRLO in a full cell is synergistically enhanced when combined with lithium bis(oxalato)borate (LiBOB) as an electrolyte additive. A discharge capacity retention of 82% is achieved after 400 cycles at room temperature. These substantial improvements are attributed to the continual reaction between boron species on the LRLO cathode surface and PF6− anions in the electrolyte. This reaction generates BF4− and suppresses HF acid formation during the high voltage charging process, demonstrating LRLO's potential for practical implementation.
Electric Double Layer Theory of Interfacial Ionic Liquids for Capturing Ion Hierarchical Aggregation and Anisotropic Dynamics
Authors: Wang Qiang , Qu Zhiguo , Tian Di 
Published: September 2024

AbstractCompared to aqueous ions, ionic liquids (ILs) consist entirely of cations and anions, and they function in energy conversion and storage owing to unique properties. Classical electric double layer (EDL) theory born a century ago gives essential insights into aqueous interfaces, whereas it fails in ILs due to overlooking ionic geometries and interactions, leaving a theoretical gap in describing IL interfaces. This study captures IL fingerprints by combining nuclear magnetic resonance experiments, quantum chemistry investigations, and first‐principles molecular simulations. Based on these findings, an EDL theory is proposed to reflect hierarchical aggregation structure and anisotropic dynamics for interfacial ILs. It involves four elements including ion geometries, ion–ion interactions, ion–wall interactions, and temperature and interfacial electric field effects. Specifically, polyatomic ions with nonuniform shapes are cornerstones for successive elements. Cation–anion non‐oxygen hydrogen bonds and cation–cation π+–π+ stacking generate bound clusters. Ion–wall adsorption causes hierarchical aggregation patterns, and cation–wall parallel stacking creates anisotropic dynamics at interfaces. Moreover, the thermal‐weakened ionic interactions and electric field‐enhanced interfacial electron transfer alter the aggregation states and dynamic properties of interfacial ILs. This theory is adaptable to various IL–wall combinations, advancing electrolyte design for next‐generation electrochemical energy devices.
Programmable Persistent Room Temperature Phosphorescence Switches through Wavelength‐Selective Photoactivation
Authors: Wang Yuchang , Shao Aiwen , Li Jiangang , Wei Juan , Wei Kuanjian , Liu Shujuan , Ma Yun , Zhao Qiang 
Published: September 2024

AbstractControlling multicolor persistent room‐temperature phosphorescence (RTP) through photoirradiation holds fundamental significance but remains a significant challenge. In this study, we engineered a wavelength‐selective photoresponsive system utilizing the Förster resonance energy transfer strategy. This system integrates a photoactivated long‐lived luminescent material as the energy donor with a fluorescent photoswitch as the energy acceptor, facilitating programmable persistent luminescence switches. Distinct afterglow color states, such as initial nonemissive, green, yellow, and orange, were achieved through irradiation at 400 nm, 365 nm, and 254 nm, respectively. Based on this capability, we established an interacting network for multistate afterglow color switching among these four emissive states. In addition, we demonstrate the potential of this wavelength‐selective photoresponsive system in the photo‐controlled rewritable printing of multicolor afterglow images on a single thin film. This work represents a substantial step towards the fabrication of sophisticated wavelength‐selective photoresponsive systems, potentially revolutionizing applications in optical data storage, security labeling, and smart displays by enabling precise control over photoresponsive behaviors under various photoirradiation wavelengths.
Microfluidization outperforms homogenization: Optimizing stability and bioaccessibility in krill oil emulsions
Authors: Huang Jia‐rong , Zhang Jian‐run , Zhang Jing , Shao Zhen‐wen , Zhou Da‐yong , Song Liang 
Published: September 2024

AbstractThis research presents a rigorous comparative analysis of high‐pressure homogenization (HPH) and microfluidization (MF) for the production of krill oil (KO) emulsions, scrutinizing their impact on oxidative stability, bioaccessibility, and the behavior under in vitro simulated digestion. Our findings revealed that MF emulsions possessed a distinct advantage, with a droplet size and distribution that promoted exceptional oxidative stability, evidenced by a sustained reduction in oxidative markers and enhanced retention of bioactive components, including EPA and DHA, and the potent antioxidant astaxanthin. In contrast, HPH yielded larger and less uniform particles, correlating with diminished stability. The in vitro digestion studies underscored the superior bioaccessibility of MF emulsions, with a pronounced release of free fatty acids during the intestinal phase, indicative of an optimized digestion and absorption process due to the smaller droplet size of the emulsions. The study's insights advocate for the adoption of microfluidization in the food industry for the development of advanced delivery systems for n‐3 fatty acids, particularly in the context of KO‐based products. The technique shows promise in enhancing the quality, stability, and bioavailability of these products, which are rich in health‐promoting lipids. The microfluidization technique emerges as a promising avenue for the fortification of a diverse range of commercial food, beverage, and pharmaceutical products with lipids that contribute to health and wellness.
Green Electrolytes for Aqueous Ion Batteries: Towards High‐Energy and Low‐Temperature Applications
Authors: Park Eunbin , Jeong Jiwon , Sung Yung‐Eun , Yu Seung‐Ho 
Published: September 2024

AbstractAqueous battery systems are increasingly recognized for their potential as environmentally friendly next‐generation energy storage solutions. However, their commercialization faces challenges due to the need for electrolytes that can operate stably at high voltages and in low‐temperatures. Traditional approaches to address these issues often involve materials that compromise the green nature. This review highlights the importance of developing environmentally friendly materials to improve the performance of aqueous electrolytes under high voltage in different types of aqueous electrolytes such as water‐in‐salt, molecular crowding electrolytes, eutectic electrolytes and cosolvents. In addition, we review advances in different types of aqueous electrolytes focused on using sustainable materials to achieve stable electrolytes at low‐temperature by suppressing water crystallization and lowering the freezing point. By integrating these innovations, we envision a future where aqueous batteries offer both high performance and eco‐friendliness, contributing significantly to the development of sustainable energy systems.
Synergistic Action of Vanillic Acid‐Coated Titanium Oxide Nanoparticles: Targeting Biofilm Formation Receptors of Dental Pathogens and Modulating Apoptosis Genes for Enhanced Oral Anticancer Activity
Authors: Rafe Hatshan Mohammad , Perianaika Matharasi Antonyraj Anahas , Marunganathan Vanitha , Rafi Shaik Mohammed , Deepak Paramasivam , Thiyagarajulu Nathiya , Manivannan Chandrakumar , Jain Divya , Melo Coutinho Henrique Douglas , Guru Ajay , Arockiaraj Jesu 
Published: September 2024

AbstractThe prevalence of bacterial and fungal infections is caused by S. aureus, S. mutans, E. faecalis, and Candida albicans are often associated with dental illnesses. In the present study, a unique strategy was used to combat these diseases by fabricating titanium dioxide nanoparticles (TiO2 NPs) conjugated with the plant‐based molecule vanillic acid (VA). To confirm the structural characterization of the synthesized VA‐TiO2 NPs, an extensive analysis was carried out utilizing methods such as SEM, FTIR, and XRD. Assessments for scavenging reactive oxygen species were performed to evaluate its antioxidant capability. Furthermore, a zone of inhibition test targeting pathogenic oral bacteria was used to assess the antibacterial efficacy of VA‐TiO2 NPs. Molecular modeling investigations were performed to better understand the interactions among vanillic acid and dental pathogen receptors using the Autodock program. The findings indicated that VA‐TiO2 NPs exhibited strong free radical scavenging activity. Additionally, they showed excellent antibacterial action towards dental pathogens, with a minimum inhibition level of 60 μg/mL. Furthermore, at doses of 15 μg/mL, 30 μg/mL, 60 μg/mL, and 120 μg/mL, VA‐TiO2 NPs demonstrated concentration‐dependent apoptotic impacts on human oral carcinoma cells. Apoptotic gene over‐expression was identified by the molecular perspectives that revealed the anticancer mechanism of VA‐TiO2 NPs on KB cells. This study highlights the promising suitability of VA‐TiO2 NPs for dental applications due to their robust antioxidant, anticancer, and antimicrobial characteristics. These nanoparticles present an evident prospect for addressing oral pathogen challenges and improving overall oral health.
Molecular Networking‐Guided Discovery of a New Antitumor Pyranonaphthoquinone from Streptomyces tanashiensis DSM 731: Insights from Single‐Molecule Stretching Assays
Authors: Cai Teng , Ding Nanjin , He Yulong , Han Tao , Wang Yanyan , Liu Chengxin , He Qiqi , Liu Chen , Li Aiying , Zhang Peng , Cai Xiaofeng 
Published: September 2024

AbstractGuided by molecular networking based on single‐molecule stretching assay, an unprecedented pyranonaphthoquinone, methyl kalafunginate (1) and five known compounds 2–6 were isolated from Streptomyces tanashiensis DSM 731. Compound 1 was characterized through a combination of spectroscopic techniques, including 1D and 2D NMR analysis, ECD calculation, and X‐ray crystallography. Interestingly, we discovered that compound 1 was spontaneously converted from kalafungin (4) in methanol solution. All isolated compounds, except for compound 3, were assessed for their cytotoxic potential against a panel of five human cancer cell lines: A549, HepG2, BxPC‐3, SW620, and C4‐2B. Compounds 1, 2, 4, and 5 exhibited remarkable cytotoxicity with IC50 values below 2.382 μM, suggesting their potential as promising anticancer agents. These findings highlight the significance of using a combined approach of single‐molecule stretching assays and molecular networking for efficiently discovering novel natural products with potential therapeutic applications.
Maxillary herpes zoster with nasociliary nerve involvement and Klebsiella superinfection: A rare occurrence
Authors: Adjei Prosper , Asasu Stanley Anenyemele , Ayeebo Michael Lennart , Donkor Eunice Ansomah , Amoakohene‐Yeboah Augustina 
Published: September 2024

Key Clinical MessageHerpes zoster is an acute cutaneous viral disease resulting from reactivation of dormant varicella‐zoster virus. The maxillary nerve is the least frequently affected branch of the trigeminal nerve. Rarely, cutaneous lesions can be secondarily infected with Klebsiella species. This report discusses a case of maxillary zoster with nasociliary nerve involvement and Klebsiella superinfection.
Spirocyclopropanes and Substituted Furans by Controlling Reactivity of 1,3‐Enynoates: γ‐ and δ‐Addition of Phosphines to Conjugate Acceptors
Authors: Chen Szu‐Han , Chen Yi‐Liang , Chen Chun‐Yu , Wu Chi‐Shiun , Su Ming‐Der , Chuang Shih‐Ching 
Published: September 2024

AbstractIn the Morita‐Baylis‐Hillman (MBH) reaction, a nucleophile undergoes β‐addition to activated alkenes or alkynes, forming reactive intermediates for subsequent carbon‐carbon or carbon‐hetero bond formation. By using a π‐conjugated acceptor, however, an unprecedented reactivity of 1,3‐enynoates and indane‐1,3‐diones was uncovered in the presence of phosphines. When indan‐1,3‐diones were used, γ‐addition of phosphines to 1,3‐enynoates was observed for the first time; moderate to good yields were obtained for 14 substances containing the prominent spirocyclopropane scaffold with 100 % retention of (Z)‐alkene. When 2‐methyl‐indan‐1,3‐diones were used, di(tri)‐substituted furans were produced through the δ‐addition pathway, with 20 substances and a yield of up to 88 % being achieved. Control experiments and density functional theory calculations were conducted to obtain insights into the unconventional γ‐addition reaction pathway.
A Cycloparaphenylene Acetylene as Potential Precursor for an Armchair Carbon Nanotube
Authors: Sidler Eric , Röthlisberger Ramon , Mayor Marcel 
Published: September 2024

AbstractThe bottom‐up synthesis of carbon nanotubes (CNTs) is a long‐standing goal in synthetic chemistry. Producing CNTs with defined lengths and diameters would render these materials and thus their fascinating properties accessible in a controlled way. Inspired by a recently reported synthesis of armchair graphene sheets that relied on a benzannulation and Scholl oxidation of a poly(p‐phenylene ethynylene), the same strategy is applied on a cyclic substrate with a short, but well defined CNT as target structure. Herein we report the synthesis of a derivatized [12]cycloparaphenylene acetylene ([12]CPPA) that was accessible employing a Sonogashira macrocyclization. The obtained macrocycle is the largest [n]CPPA reported to date and displays bright turquoise fluorescence with a large quantum yield of 77 %. The [12]CPPA can be transformed by a 12‐fold benzannulation that converts each alkyne to a naphthalene and therefore allows formation of an armchair [12,12]CNT precursor. The final 72‐fold Scholl oxidation to the [12,12]CNT turned out to be challenging and its optimization requires an improved synthetic strategy to produce large quantities of the final precursor. The developed approach poses a potential break through strategy for the production of CNTs and certainly incentivizes synthetic chemists to apply the same methodology for various conjugated macrocycles.
Impacts of post‐operation loading and fixation implant on the healing process of fractured tibia
Authors: Doorandish Yazdi Shima , Hedayat Dorna , Asadi Amir , Abouei Mehrizi Ali 
Published: September 2024

AbstractHealing of tibia demonstrates a complex mechanobiological process as it is stimulated by the major factor of strains applied by body weight. The effect of screw heads and bodies as well as their pressure distribution is often overlooked. Hence, effective mechanical conditions of the healing process of tibia can be categorized into the material of the plate and screws, post‐operation loadings, and screw type and pressure. In this paper, a mathematical biodegradation model was used to simulate the PGF/PLA plate‐screw device over 8 weeks. The effect of different post‐operation loading patterns was studied for both locking and non‐locking screws. The aim was to reach the best configuration for the most achievable healing using FEA by computing the healing pattern, trend, and efficiency with the mechano‐regulation theory based on deviatoric strain. The biodegradation process of the plate and screws resulted in 82% molecular weight loss and 1.05 GPa decrease in Young's modulus during 8 weeks. The healing efficiency of the cases ranged from 4.72% to 14.75% in the first week and 18.64% to 63.05% in the eighth week. Finally, an optimal case was achieved by considering the prevention of muscle erosion, bone density reduction, and nonunion, according to the obtained results.
Potential genetic gains from targeted recombination versus recurrent selection for maize yield and moisture
Authors: Cameron John N. , Bernardo Rex 
Published: September 2024

AbstractRecurrent selection is a proven method and targeted recombination is a potential method for achieving genetic gain. Our objectives were to determine the (1) equivalency in predicted gains between cycles of recurrent selection and targeted recombination in maize (Zea mays L.), (2) correspondence between targeted‐recombination positions when gains from nontargeted chromosomes are considered versus ignored, and (3) trade‐offs in predicted gains for yield and moisture in targeted recombination. From genomewide marker effects for 2911 single nucleotide polymorphism loci in 270 biparental populations, we obtained predicted gains from fixed numbers of targeted recombinations and compared these gains to the genotypic‐value distributions of doubled haploids obtained from different cycles of simulated recurrent selection. On average, it took three cycles of single‐trait recurrent selection to obtain at least a few doubled haploid lines with the same performance achieved with nine or 10 targeted recombinations in Cycle 0. Results indicated that when targeting recombinations across the genome, gains from segregation on nontargeted chromosomes do not need to be considered. Predicted increases in yield were associated with increases in moisture. Given the logistics of pyramiding targeted recombinations and the lack of mature technologies for routine targeted recombination, recurrent selection is currently the preferred approach for accumulating favorable recombinations.