bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prognosefaktoren der offenen Abdominalbehandlung in der Viszeralchirurgie
Authors: von Websky Martin , Jedig Agnes , Willms Arnulf , Jafari Azin , Matthaei Hanno , Kalff Jörg , Manekeller Steffen 
Published: April 2017

Zusammenfassung
Einführung In der Allgemeinchirurgie dient die offene Abdominalbehandlung (OAT) der Behandlung von abdominellem Kompartmentsyndrom (ACS) und Sepsis, häufig nach einer mit Komplikationen verbundenen Primäroperation. Die Ergebnisse bei diesem Kollektiv hängen möglicherweise von noch unbekannten Faktoren ab. In dieser Studie werden unabhängige patientenbezogene Prognosefaktoren nach OAT untersucht.
Methoden Es wurden 38 klinische Parameter und Überlebensdaten zu 165 konsekutiven Patienten der Allgemeinchirurgie nach OAT gemäß einem festgelegten klinischen Algorithmus in eine prospektive Datenbank eingegeben. Bewertet wurden die chirurgische Grunderkrankung, Überlebensprädiktoren und wichtige Aspekte OAT-bezogener Morbidität. Es wurden unabhängige Prädiktoren für Überleben, OAT-bezogene Morbidität und Dauer des Krankenhausaufenthalts identifiziert.
Ergebnisse OAT-Indikationen waren häufig Peritonitis, Blutungen und ACS. Das Durchschnittsalter der Patienten lag bei 60 Jahren und > 80 % gehörten der Kategorie ASA III/IV an; die Nachuntersuchung erfolgte im Durchschnitt nach 23 Monaten. In 19 % der Fälle waren onkologische Eingriffe erfolgt. Die 30-Tage-Mortalität lag bei 11 %, die 1-Jahres-Mortalität bei 34 %. Malignität war ein negativer Prädiktor (OR 4,63; 95 %-KI: 2,00–10,7), während Übergewicht/leichte Adipositas (BMI 25–35) sowie primärer Faszienverschluss, der bei 82 % der Patienten erreicht wurde, die Überlebensrate verbesserte (OR 0,2; 95 %-KI: 0,07–0,55) bzw. (OR 0,19; (95 %-KI: 0,06–0,57). Nach OAT war häufig das Auftreten einer enteroatmosphärischen Fistel (19 %, EAF) und einer ventralen Hernierung bei unmöglichem Faszienverschluss (18 %) zu verzeichnen. Malignität war ein unabhängiger Risikofaktor für EAF (OR 3,47; 95 %-KI: 1,41–8,53). Weder ein vakuumassistierter Wundverschluss noch eine Polyglactin-Netzeinlage wirkten sich auf das Auftreten der EAF aus.
Schlussfolgerung Allgemeinchirurgische Patienten nach OAT unterscheiden sich signifikant von Traumakohorten, und Mortalität sowie Langzeitmorbidität sind hoch. Der Ausgang wird wesentlich von unabhängigen patientenbezogenen Faktoren nach OAT bestimmt. Zur Verbesserung der Ergebnisse nach OAT wird eine individuell angepasste chirurgische Versorgung auf der Grundlage objektiver Nachweise benötigt.
Reactive Rather than Proactive Diabetes Management in the Perioperative Period
Authors: Hommel Inge , van Gurp Petra , den Broeder Alfons , Wollersheim Hub , Atsma Femke , Hulscher Marlies , Tack Cees 
Published: April 2017

AbstractAs perioperative hyperglycemia is associated with poor postoperative patient outcomes, clinical guidelines provide recommendations for optimal perioperative glucose control. It is unclear to what extent recommended glucose levels are met in daily practice, and little is known about factors that influence these levels. We describe blood glucose levels throughout the hospital care pathway in 375 non-critically ill patients with diabetes who underwent major surgery (abdominal, cardiac, or orthopedic) in 6 hospitals, examine determinants of these levels including adherence to 9 quality indicators for optimal perioperative diabetes care, and perform qualitative interviews to identify barriers for optimal care. Virtually all patients (95%) experienced at least one hyperglycemic value (>10 mmol/l); 9% had at least one value <4 mmol/l. Mean glucose increased from preoperative to postoperative day (POD) 1 (+2.3 mmol/l, 5–95% CI 1.9–2.7), and then gradually decreased on POD 2–14 (+1.8 mmol/l, 5–95% CI 1.4–2.2). Insulin-treated patients (with or without oral agents) had higher glucose levels (+1.7 mmol/l, 5–95% CI 0.5–3.0, and +1.2 mmol/l, −0.1 to −2.5) than patients using oral agents only. Indicator adherence tended to be associated with higher glucose levels. Barriers for optimal care included a lack of formalized agreements on target glucose levels, absence of directly obvious disadvantages of hyperglycemia, and concern about inducing hypoglycemia. Hyperglycemia is common after major surgery, in particular on POD1 and in insulin-treated patients. Our results suggest that perioperative diabetes care is reactive rather than proactive, and that current emphasis of professionals is on treating instead of preventing postoperative hyperglycemia.
Prevalence of Helicobacter pylori infection among blood donors in Saxony-Anhalt, Germany – a region at intermediate risk for gastric cancer
Authors: Franck Caspar , Hoffmann Armin , Link Alexander , Schulz Christian , Wuttig Kerstin , Becker Elke , Heim Marcell , Venerito Marino , Malfertheiner Peter 
Published: April 2017

Abstract
Background In the federal state of Saxony-Anhalt, gastric cancer (GC) incidence ranks among the highest in Germany. Helicobacter pylori prevalence is a surrogate marker for GC risk in a given population. In 2010 we reported an H. pylori seroprevalence of 44.4 % in patients at the emergency ward of the University Hospital of Magdeburg, the capital of Saxony-Anhalt. Our aim is to update these findings in a cohort of healthy blood donors from the same region.
Materials and methods The sera of 516 consecutive blood donors (40.1 ± 14.1 years; 286 males and 230 females) were tested for antibodies against H. pylori and CagA. Data on demographics and previous H. pylori eradication therapy were obtained by means of a structured questionnaire. Blood donors with positive serology for H. pylori or CagA and/or history of eradication therapy were classified as H. pylori-positive.
Results Overall, 28.9 % of the study cohort were H. pylori-positive. The prevalence was higher in older generations (9 % in 18 – 20 years up to 47 % in 61 – 70 years). In 44.4 % of H. pylori IgG-positive donors, CagA serology was also positive. This proportion was not age-dependent. Study participants with siblings were by trend more often H. pylori-positive (p = 0.066).
Conclusion Compared to our previous study in patients at the emergency ward, we found by trend lower age-related H. pylori prevalence rates. In our cohort of healthy blood donors, we confirmed a lower H. pylori prevalence in younger generations.
Faulkner et Camus face à Dostoïevski
Authors: Kouchkine Eugène 
Published: April 2017

Abstract
Based on the analysis of Faulkner’s novel Requiem for a Nun and its stage adaptation by Camus, this article focuses on the elements that connect the two authors and aims to illustrate their relationship with Dostoïevski’s work. The interest is mainly directed towards the theme of suffering as it is revealed in the Russian novelist’s writings and its exploitation through Faulkner and Camus’s dramatic art and work.
Paraboles de guerre
Authors: Lund Hans Peter 
Published: April 2017

AbstractThis article reveals the connection existing betweenA Fableby Faulkner,La Pesteby Camus, andLa Route des Flandresby Simon, with the three novels sharing a parabolic and symbolic vision of war. While Faulkner’s novel evidences a true christology with a lot of biblical references, Camus and Simon sometimes refer to the Bible, as the American writer does, or to ancient mythology. The fictional characters are shown facing clearly the same dis-membering of time, as well as an implacable and very Faulknerian evil that strikes them inevitably, and against which Faulkner and Camus’s characters revolt.
Requiem pour une nonne de Camus
Authors: Lupo Virginie 
Published: April 2017

Abstract
Unlike other adaptations that he has himself chosen, Requiem for a Nun, which was adapted and staged in 1957, is the fruit of a proposal to which Camus responded positively. That’s why I want to examine Camus’ personal motivation for writing this play. I will analyze it in the light of one of Milan Kundera’s texts: Jacques et son maître, Hommage à Denis Diderot en trois actes – which is an adaptation of Jacques et son maître by Denis Diderot – and I will try to see if it is an adaptation, a variation (term borrowed from the music and from Kundera) or a tribute from Camus to Faulkner.
Tragédie et psychologie
Authors: Sändig Brigitte 
Published: April 2017

Abstract
His dislike for psychological analysis accompanied Albert Camus throughout his life and had a profound impact on his idea of theatre. Especially in his early years, he sees psychology as the antagonist of the kind of theater that he envisages, the “modern tragedy”. In the last decade of his life, Camus worked on the novel “Requiem for a Nun” by William Faulkner, whom he greatly respected, in order to stage it. The confrontation with this work and its highly psychologically driven plot makes Camus virtually give up on his anti-psychological attitude.
Lyrisme et paysage chez Camus et Faulkner
Authors: Coquet Clotilde 
Published: April 2017

Abstract
This article links Camus’s recurrent lyrical themes and motifs with those of Faulkner. The speeches delivered by the two authors on receiving the Nobel Prize clearly underpin their conception of the art of writing, torn between suffering and beauty. For them the landscape alone can serve as a generative core to reveal the country itself. This article questions the tension raised by the South (Algeria and the imaginary county of Yoknapatawpha) and the authors’ aspiration for a lyrical prose liberated from the pressure of fiction writing. It outlines a parallel between their destiny and their accidental deaths.
Approches d’une modernité
Authors: Prioult Christiane 
Published: April 2017

Abstract
This work deals with the main interests of William Faulkner and Albert Camus as far as modernity is concerned, and includes the problems of time, conscience and truth, as well as guilt and man’s future. Through the reality of their individual experience, and facing the ethical demands of collective history, as well as the questioning of temporality, the American novelist and the French essayist have shown the dramatic contingencies of historical events. In the darkness of present times they searched for the hope for man to survive which lies in himself, in his capacity to transform the transient, ephemeral present into the capture of the possible by human conscience, and to leave the door open to the possibility of connecting the self to others.
William Faulkner au croisement de deux hommes de théâtre
Authors: Mazza Vincenzo 
Published: April 2017

Abstract
Camus and Barrault collaborated in 1948 to create the ill-fated L’État de siège. The two theatrical figures had already crossed paths, however, at a different time and for different reasons, thanks to Faulkner’s work and Maurice Edgar Coindreau’s translations. Barrault chose As I lay Dying for his first production in 1935, and Camus opted for Requiem pour une nonne in 1956. This study analyses archival documents and press clippings about these two works in order to provide a deeper understanding of the adaptive process and the staging solutions adopted by Camus and Barrault in their respective productions.
Habitat Use and Arrival Timing of Hatchery and Naturalized Chinook Salmon Spawning in a Great Lakes Tributary
Authors: Marklevitz Stephen A. C. , Morbey Yolanda E. 
Published: April 2017

AbstractLarge‐scale stocking programs have been used to introduce and maintain Chinook Salmon Oncorhynchus tshawytscha fisheries in the Laurentian Great Lakes since the late 1960s, with discoveries of naturalized populations in tributaries soon after the initial introduction. Characterizing ecological differences between hatchery and naturalized Chinook Salmon is becoming increasingly important for sustainable management of this species. We hypothesized that nonheritable traits (i.e., homing) and artificial selection might result in different habitat use and arrival timing between rearing origins occupying the same river, with the potential for reproductive isolation and divergence of naturalized and hatchery strains. In 2010 and 2011, using visual observations and PIT tags, we tracked individual hatchery and naturalized Chinook Salmon that spawned in the Sydenham River (Owen Sound, Ontario), one of the first tributaries in Lake Huron to be colonized by hatchery strays and establish a naturalized population. We estimated that 52–58% of the 3,200–3,300 fish returning to spawn in 3.5 km of accessible spawning habitat were hatchery fish. In females, the extent of prespawning movement increased with arrival date, decreased with fish length, and was lower for hatchery fish. Hatchery females also displayed a higher probability of direct homing to the stocking site than naturalized females. Prespawning movements by males were extensive but did not depend on rearing origin, arrival timing, or body size. We found no evidence of reproductive isolation, however. Spatial distributions of spawning locations were independent of rearing origin for both sexes, and arrival timing in the river was similar between rearing origins for both sexes. The lack of reproductive isolation is likely attributable to the small area of suitable habitat in this river. Our study represents the first comprehensive comparison of spawning habitat use and timing by hatchery and naturalized Chinook Salmon in the Great Lakes.Received October 26, 2016; accepted February 22, 2017 Published online April 24, 2017
Trends in Rainbow Trout Recruitment, Abundance, Survival, and Growth during a Boom‐and‐Bust Cycle in a Tailwater Fishery
Authors: Korman Josh , Yard Michael D. , Kennedy Theodore A. 
Published: April 2017

AbstractData from a large‐scale mark–recapture study were used in an open‐population model to determine the cause for long‐term trends in growth and abundance of a Rainbow TroutOncorhynchus mykisspopulation in the tailwater of Glen Canyon Dam, Arizona. Reduced growth affected multiple life stages and processes, causing negative feedbacks that regulated the abundance of the population, including higher mortality of larger fish; lower rates of recruitment (young of the year) during years when growth was reduced; and lower rates of sexual maturation in the following year. High and steady flows during spring and summer 2011 resulted in a very large recruitment event. The population had declined tenfold by 2016 due to a combination of lower recruitment and reduced survival of larger trout. Survival rates for 225‐mm and larger Rainbow Trout in 2014, 2015, and 2016 were 11, 21, and 22% lower, respectively, than average survival rates between 2012 and 2013. Abundance at the end of the study would have been threefold to fivefold higher if survival rates for larger individuals had remained at the elevated levels estimated for 2012 and 2013. Growth declined between 2012 and 2014 owing to reduced prey availability, which led to very poor fish condition (~0.90–0.95) by fall 2014. Poor condition in turn resulted in low survival rates of larger fish during fall 2014 and winter 2015, which contributed to the population collapse. In Glen Canyon, large recruitment events driven by high flows can lead to population increases that cannot be sustained due to limitations in prey supply. When the ability to regulate prey supply is lacking, flows that reduce the probability of large recruitment events can be used to avoid boom‐and‐bust population cycles. Our study demonstrates that mark–recapture is a very informative approach for understanding the dynamics of tailwater trout populations.Received December 6, 2016; accepted March 31, 2017 Published online August 2, 2017
Ionically conducting oxide composite thin films and heterostructures
Authors: Zhang Bowen 
Published: April 2017

Ionic conductivity in oxide composite thin films has recently drawn growing attention due to the unique interfacial phenomena and huge application potential. In this review article the author presents the recent progress in three materials classes including (1) the single-layer heteroepitaxial structures, (2) multilayer structures, and (3) vertically aligned heteroepitaxial structures. This review aims to give an overview of this field and offer guidelines to understand the interfacial phenomena. Two promising research directions in this field are proposed at the end, including understanding the interfacial phenomena in heterostructures, and exploring new methods which can separate thin films from their substrates. This review was submitted as part of the 2017 Materials Literature Review Prize of the Institute of Materials, Minerals and Mining run by the Editorial Board of MST. Sponsorship of the prize by TWI Ltd is gratefully acknowledged
Simultaneous Germinal Vesicle Migration and Oil Droplet Coalescence Predict Final Oocyte Maturation in the Leopard Grouper
Authors: Romo-Mendoza Daniel , Campos-Ramos Rafael , Burgos-Aceves Mario A , Guerrero-Tortolero Danitzia A 
Published: April 2017

Abstract
The size of oocytes during germinal vesicle migration (GVM) and germinal vesicle breakdown (GVBD) was revised for the Leopard Grouper Mycteroperca rosacea. Histology of ovaries, plasma levels of estradiol-17ß (E2), and testosterone (T) were analyzed in Leopard Grouper at 0, 12, 16, and 24 h after a priming dose of 1,000 IU/kg body weight of human chorionic gonadotropin (hCG) and were compared with control females injected with saline solution. Histological observations were verified in hormonally induced females by observing in vivo intraovarian biopsies after using the same priming dose and a second resolving dose of 500 UI/kg body weight of hCG 16 or 24 h later, which served to analyze spawning performance. Histological and in vivo intraovarian biopsies showed that in full-yolk oocytes (~455 μm diameter) GVM and GVBD were concomitant with coalescence of a single oil droplet 16 and 24 h after the first injection. The oil droplet became a morphological marker as well as a predicting indicator of the competence and synchronization of maximum vitellogenic oocytes and the effectiveness to respond to hormonal therapy. In the experimental fish group E2 and T reached peaks at the same time, which were significantly higher than those in the controls. Mean fecundity was 168,000 eggs/kg, mean fertilization was 88%, and mean viability was 71% (114,000 eggs/kg), all of which were within the range of other cultivated groupers. These results can be used to improve the induction of final maturation in the Leopard Grouper in captivity and may be used in other species of Mycteroperca that show the same marker.
Growth of Pacific White Shrimp Fed Diets Containing a Mixture of Soybean Meal and Tuna Silage
Authors: Hernández C , Olvera-Novoa M A 
Published: April 2017

Abstract
This study evaluated the use of tuna by-product silage (TBS) in diets based on soybean meal (SBM) for the Pacific white shrimp Litopenaeus vannamei. A diet based on fish meal (FM, positive control) only was compared with five isonitrogenous formulations (35% crude protein) based on SBM containing increasing dietary levels of TBS (0, 14.9, 29.8, 44.7, or 59.6%) replacing 0% (TBS0, negative control), 25% (TBS25), 50% (TBS50), 75% (TBS75), or 100% (TBS100), respectively, of the protein derived from SBM. A diet containing tuna by-product meal (TBM) as the sole protein source and one using a commercial feed as reference were also included. Each diet was tested on shrimp in triplicate over 41 d using 70-L fiberglass tanks in a closed recirculating system. Each tank was stocked with 10 juvenile shrimp (mean initial weight, 1.09 g). Shrimp fed diet TBS25 grew as well as those fed diets with 100% of the protein from FM. The growth differences were mainly attributable to differences in the nutritional quality of diets. Whole-body composition was significantly affected by diet. The broken-line regression model using thermal growth coefficient data allowed us estimate that the maximum inclusion level of TBS in shrimp fed the SBM-based diet was 26.31%. To reduce the cost of shrimp feed, the ratio of 75% SBM and 25% TBS proteins seems to be the best formulation for juvenile Pacific white shrimp diets.
When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants
Authors: Pagel Kymberleigh A , Pejaver Vikas , Lin Guan Ning , Nam Hyun-Jun , Mort Matthew , Cooper David N , Sebat Jonathan , Iakoucheva Lilia M , Mooney Sean D , Radivojac Predrag 
Published: April 2017

Abstract

Motivation
Loss-of-function genetic variants are frequently associated with severe clinical phenotypes, yet many are present in the genomes of healthy individuals. The available methods to assess the impact of these variants rely primarily upon evolutionary conservation with little to no consideration of the structural and functional implications for the protein. They further do not provide information to the user regarding specific molecular alterations potentially causative of disease.

Results
To address this, we investigate protein features underlying loss-of-function genetic variation and develop a machine learning method, MutPred-LOF, for the discrimination of pathogenic and tolerated variants that can also generate hypotheses on specific molecular events disrupted by the variant. We investigate a large set of human variants derived from the Human Gene Mutation Database, ClinVar and the Exome Aggregation Consortium. Our prediction method shows an area under the Receiver Operating Characteristic curve of 0.85 for all loss-of-function variants and 0.75 for proteins in which both pathogenic and neutral variants have been observed. We applied MutPred-LOF to a set of 1142 de novo vari3ants from neurodevelopmental disorders and find enrichment of pathogenic variants in affected individuals. Overall, our results highlight the potential of computational tools to elucidate causal mechanisms underlying loss of protein function in loss-of-function variants.

Availability and Implementation
http://mutpred.mutdb.org
veqtl-mapper: variance association mapping for molecular phenotypes
Authors: Brown Andrew Anand 
Published: April 2017

Abstract

Motivation
Genetic loci associated with the variance of phenotypic traits have been of recent interest as they can be signatures of genetic interactions, gene by environment interactions, parent of origin effects and canalization. We present a fast efficient tool to map loci affecting variance of gene expression and other molecular phenotypes in cis. Results: Applied to the publicly available Geuvadis gene expression dataset, we identify 816 loci associated with variance of gene expression using an additive model, and 32 showing differences in variance between homozygous and heterozygous alleles, signatures of parent of origin effects.

Availability and implementation
Documentation and links to source code and binaries for linux can be found at https://funpopgen.github.io/veqm/.

Supplementary information
Supplementary data are available at Bioinformatics online.