bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unmet needs to admission in physical and rehabilitation inpatient department in Low and Middle Income Countries in 2023
Authors: Moncer Rihab , Feni Nedra , Houssem Ghorbel , Loubiri Ines , Mtaouaa Sahbi , Jemni Sonia , Abdelaziz Ahmed Ben 
Published: October 2024

Background
Determining the needs to access to rehabilitation structures is essential for developing effective improvement strategies. The objective of this study was to determine the percentage of unmet needs to admission to rehabilitation and their associated factors.

Methods
It is a cross sectional study in the inpatient rehabilitation department Sahloul Hospital of Sousse, tertiary care center including all requests to admission. Patient demographics, diagnoses, admission decisions, and post-decision outcomes were collected for each request.

Results
Of 329 admission requests, 316 were eligible. The mean patient age was 45 years, with a male-to-female ratio of 0.84. Most requests originated from the hospital’s outpatient department, neurology, and orthopedics. Among all requests, 40.5% were not admitted. Non-neurological diagnoses and patient residency were associated with non-admission. Patients with non-neurological conditions and those residing outside the city had twice the risk of non-admission. At one month, 63% of non-admitted patients experienced functional decline, and 18% were lost to follow-up.

Conclusion
Unmet needs to admission in rehabilitation structures is high due to lack of beds. This is leading of inequity of access to such important phase of care more. This study highlighted throwing the example of physical and rehabilitation department the gap of needs and the capacity of inpatient rehabilitation facilities. Healthcare policies should prioritize increasing rehabilitation bed availability in all regions of the country.
Study protocol for the development of a real-time interface showing the availability of breast and cervical cancer services in Ghana
Authors: Sutherland Edward Kofi , Smith Justin Dean , Ofori-Boateng Millicent , Kushitor Sandra Boatemaa , Sarkwah Hammond Nii , Kwanin Bernard Agyei , Sward Katherine Ann , Gouripeddi Ramkiran , Manortey Stephen Oluaku , Price Matthew Dean , Rositch Anne , Ngwa Wil , Alder Stephen Craig , Joshu Corrine , Price Raymond Richard 
Published: October 2024

Background
The 5-year survival rates for breast and cervical cancers in Ghana are low in comparison to rates in developed countries. This striking disparity is attributed to numerous factors, including limited access and navigability to appropriate services. A one-time cross-sectional, hospital-based survey was performed by the University of Utah in collaboration with Ghana Health Services (GHS) and Health Facilities Regulatory Agency (HeFRA) from November, 2020 to October, 2021 so as to determine existing hospital-based breast and cervical cancer care services capacity and their geographic availability nationwide. This related information remains dynamic in nature and time. The current project employs a public-academic implementation science and research configuration to explore and develop a real-time interface (RTIF) showing the availability of breast and cervical cancer care services at hospital facilities in-country so as to anchor up-to-date data products for the government, private-sector, and patient-centric consumption.

Methods and analysis
Multiple methods will be employed to achieve the study objectives between December 2023 to November 2024. The first three objectives shall focus on contextual, needs, and feasibility assessments guided by the domains and constructs within the updated Consolidated Framework for Implementation Research (CFIR) during coding and thematic qualitative analysis. Using purposive sampling, breast and cervical cancer care service stakeholders shall be identified for individual in-depth interviews. The fourth objective will involve creating the RTIF prototype and piloting it in the Eastern Region of Ghana. The final and fifth objective shall employ the systems usability scale (SUS) amongst ten randomly selected individual stakeholders to assess the technical functionality of the interface. A nationwide scale-up shall follow this.
Characterization of a novel variant in KCNJ16, encoding Kir5.1 channel
Authors: Xu Biyang , Levchenko Vladislav , Bohovyk Ruslan , Ahrari Ameneh , Geurts Aron M. , Sency Valerie , Xin Baozhong , Wang Heng , Staruschenko Alexander 
Published: October 2024

AbstractThe essential role of the inwardly rectifying potassium channel Kir5.1 (KCNJ16) in controlling electrolyte homeostasis and blood pressure has been demonstrated in human and animal studies. Previous studies have identified several bi‐allelic mutations of KCNJ16 in humans, causing severe hypokalemia, renal salt wasting, and disturbed acid–base homeostasis. Here, we identified a novel homozygous variant of KCNJ16, I26T, in an Amish patient affected with polydipsia, developmental delay, and chronic metabolic acidosis with low serum bicarbonate concentration. Subsequently, we generated the rat model with I26T mutation using Dahl salt‐sensitive rat (I26T rat) to characterize this variant. The male mutant rats displayed similar blood pressure and electrolyte homeostasis under baseline and with a high salt (4% NaCl) challenge. Blood pH, HCO3− and renal damage also remained similar between WT and I26T rats after high salt challenge. Additionally, single‐channel patch clamp analysis revealed similar channel activity in CHO cells overexpressed with WT and I26T mutant Kir4.1/5.1 channels. In summary, this study reported a novel variant in KCNJ16, namely I26T, which is likely a benign variant and not associated with pathologic phenotype in either human or Dahl salt‐sensitive rats, indicating that the type/location of variant should be considered when diagnosing and treating patients with KCNJ16 mutations.
Arterial to jugular‐bulb lactate difference in patients undergoing elective brain tumor craniotomy
Authors: Vassilieva Alexandra , Olsen Markus Harboe , Skjøth‐Rasmussen Jane , Møller Kirsten , Sørensen Martin Kryspin 
Published: October 2024

AbstractHyperlactatemia is common during tumor craniotomy, but the underlying pathophysiology is unclear. This study measured simultaneous arterial and jugular‐bulb lactate concentrations in patients undergoing brain tumor craniotomy to investigate the hypothesis that hyperlactatemia was associated with a net cerebrovascular lactate input. In 20 patients, arterial and jugular‐bulb blood was collected hourly from the start of surgery to 6 h postoperatively for measurement of lactate, glucose, and oxygen concentration. For each marker, data were analyzed using a linear mixed‐effects model with jugular‐bulb concentration as dependent variable, arterial concentration as fixed effect, and patient as random effect. Furthermore, we generated regression lines between arterial and jugular‐bulb concentrations. The slope of the regression line between arterial and jugular‐bulb lactate was 0.95 (95% CI 0.93–0.97, R2 = 0.98), indicating that increasing arterial lactate levels were associated with an increasingly positive net cerebrovascular balance (net input). The line crossed the identity line at 2.86 (95% CI 0.57–5.16) mmol/L, indicating that lower levels of lactate were associated with a negative net cerebrovascular balance (net output). This suggests a switch from net lactate output during normolactatemia towards net input during hyperlactatemia. Hyperlactatemia in tumor‐craniotomy patients probably does not originate from the brain.
Involvement of pentraxin‐3 in the development of hypertension but not left ventricular hypertrophy in male spontaneously hypertensive rats
Authors: Mkhize Siluleko A. , Manilall Ashmeetha , Mokotedi Lebogang , Gunter Sule , Michel Frederic S. 
Published: October 2024

AbstractHypertension drives the development of concentric left ventricular hypertrophy (LVH). However, the relative contribution of pentraxin‐3 (PTX‐3), a novel marker for inflammatory cardiovascular disease, in the hypertrophic response to pressure overload has not been adequately elucidated. We investigated the role of PTX‐3 in the development of LVH in spontaneously hypertensive rats (SHR), untreated and treated with either captopril (an ACE inhibitor) or hydralazine (a non‐specific vasodilator). Three‐month‐old SHR received either 20 mg/kg/day hydralazine (SHR + H, n = 6), 40 mg/kg/day captopril (SHR + C, n = 6), or plain gelatine cubes (untreated SHR, n = 7) orally for 4 months. Wistar Kyoto rats (WKY, n = 7) were used as the normotensive controls. Blood pressure (BP) was measured using the tail‐cuff method. Cardiac geometry and function were determined using M‐mode echocardiography. Circulating concentrations of inflammatory markers were measured in plasma by ELISA. LV fibrosis and cardiomyocyte width were assessed by histology. Relative mRNA expression of PTX‐3 was determined in the LV by RT‐PCR. Untreated SHR exhibited greater systolic BP and relative wall thickness (RWT) compared to WKY. Captopril and hydralazine normalized BP but only captopril reversed RWT in SHR. Circulating PTX‐3 and VCAM‐1 levels were elevated in untreated SHR and reduced with captopril and hydralazine. Circulating PTX‐3 was positively associated with systolic BP but lacked independent relations with indices of LVH. LV relative mRNA expression of PTX‐3 was similar between the groups. PTX‐3 may not be involved in the development of LVH in SHR, but plausibly reflects the localized inflammatory milieu associated with hypertension.
On the matching arrangement of a graph and properties of its characteristic polynomial
Authors: Bolotnikov Alexey I. 
Published: October 2024

Abstract
We consider a hyperplane arrangement constructed from a subset of the set of all simple paths in a graph. A relation of the constructed arrangement to the maximum matching problem is established. In addition, the problem of finding the characteristic polynomial is reduced to the case of a connected original graph. In the case where the original graph is a tree, a formula for the characteristic polynomial is obtained.
Effect of the reinforcement ratio on the mechanical behaviour of textile-reinforced concrete composite: Experiment and numerical modeling
Authors: Nguyen Xuan Bang , Tran Manh Tien , Hong Vu Xuan , Ferrier Emmanuel 
Published: October 2024

Abstract
Over the past decade, the textile-reinforced concrete (TRC) composite was gradually used to replace the fibre-reinforced polymer in the strengthening or repairing of existing reinforced-concrete structures, thanks to many criteria of sustainable development. The reinforcement ratio of textiles within TRC composites emerges as a crucial factor significantly impacting their reinforcement effectiveness, altering the material’s mechanical behaviour and properties. This study presents both experimental and numerical findings concerning the tensile behaviour of carbon TRC composites, exploring reinforcement ratios ranging from 0.5 to 1.5%. As experimental results, the carbon TRC specimens exhibited a strain-hardening behaviour with the cracking phase. The ultimate strength improved by 95 and 146% compared to that of non-reinforced specimens, respectively, with the reinforcement ratio of 0.92 and 1.32%. As numerical results, the model reached the strain-hardening curve with three distinct phases when the reinforcement ratio was higher than a critical value (0.7%). The effect of reinforcement ratio ranging from 0.5 to 1.5% on the mechanical behaviour and properties of carbon TRC was also highlighted and analysed.
Vector optimization problems with weakened convex and weakened affine constraints in linear topological spaces
Authors: Zeng Renying 
Published: October 2024

Abstract
In this article, we work on vector optimization problems in linear topological spaces. Our vector optimization problems have weakened convex inequality constraints and weakened affine equality constraints. Our inequalities are given by partial orders that are induced by pointed convex cones. We prove a Farkas–Minkowski-type theorem of alternative and obtain some optimality conditions through the discussions of vector saddle points and scalar saddle points.
Legal Involvement in Pediatric Cancer Treatment Refusal: A Qualitative Study
Authors: Caruso Brown Amy E. , Beskow Laura M. , Benedetti Daniel J. 
Published: October 2024

OBJECTIVES
To characterize the spectrum of legal options considered in cases of treatment refusal, nonadherence, and abandonment (TRNA); clinicians’ thought processes regarding legal intervention; and perceived consequences of legal involvement.

METHODS
We conducted in-depth, semistructured interviews with 30 pediatric oncologists between May and September of 2019 regarding experiences with TRNA. The interview guide covered types of conflicts encountered; factors and strategies considered in response; effects of TRNA cases, personally and professionally; the role of ethical frameworks and legal requirements; and resources needed to manage TRNA cases. Interviews were transcribed and coded iteratively using thematic analysis.

RESULTS
Participants represented a range of institutional sizes, geographic locations, and years in practice. Twenty-five of 30 interviewees discussed legal consideration with regard to TRNA. Most participants first engaged the legal system through child protective service agencies. They considered patient age, treatment efficacy, quality of life (burden of treatment), and prognosis; family resources and social context; and preservation of therapeutic relationships and possible consequences of reporting. Experiences and outcomes of legal involvement varied.

CONCLUSIONS
Clinicians struggle with the tension between obligations to report medical neglect and fears that reporting may result in more harm than benefit to the child in question. We urgently need more dialog between health care professionals and child protective services and legal professionals. Stakeholders from both groups would benefit from a greater understanding of the other’s thought processes; clarity regarding the relevant facts; and mutual progress toward creative, evidence-based solutions to working out these complex challenges.
Формування концепту космологічних моделей архітектури та містобудівництва у гуманітарних науках: філософські сенси
Authors: Мазур Олена 
Published: October 2024

Актуальність. У сучасній філософсько-гуманітарній думці відбувається просторовий поворот (spatial turn) і феномен простору і концепт «простору» досліджується у глибинному взаємозв'язку з іншими феноменами культури та буття. Саме на такому перетині виникає стійкий інтерес у міждисциплінарній площині гуманітаристики до «сакральних» просторів» і до одного з його різновидів - космологічного простору, що знайшло своє відображення в перших спорудах сакральної архітектури, план і форма яких відтворювала космічний небесний порядок.
Метою дослідження є прослідкувати формування, генезу космологічних моделей архітектури та містобудування в теоретичній рецепції сучасної гуманітаристики.
Результати. Зроблено аналіз етимології терміна «космологічні моделі архітектури та містобудування» у понятійно- категоріальному апараті світової та вітчизняної філософії та гуманітаристики.
Висновки. Виявлено в міждисциплінарних дослідженнях космологічних моделей стародавньої архітектури глибоко архаїчне, але по суті універсальне загальнолюдське уявлення про світ, що додало дослідженням філософський потенціал. Застосувавши метод культурологічного підходу в історії філософії, встановлено в текстах філософсько значущі ідеї та філософсько навантажені терміни , які залучено для нашого філософського аналізу : «просторова чутливість» (“spatial sensibility”), «релігійна просторовість» (“spatialité religieuse”), семіотичні коди, фази космізації, umbilicus orbis, фокус, осі космосу, imago mundi, аxis mundi, domus, dominus, madonna, «святе місце», космізований простір, священний простір та інші .Знайти філософські відповіді або висунути філософські гіпотези - завдання майбутніх публікацій.
The Protestant Connection in André Gide's Les faux-monnayeurs and French Literary Modernism
Authors: Fauré-Bellaïche Clémentine 
Published: October 2024

AbstractThis article revisits André Gide's emblematically modernist novel, Les faux-monnayeurs (1925; The Counterfeiters), by reevaluating the importance and significance of the setting at the center of the narrative: the “pension Azaïs-Vedel,” a Protestant educational institution around which all the novel's characters—mostly adolescents—gravitate and all the subplots converge. It shows how Gide's choice of setting responded to the “quarrel of classicism,” which reconfigured the French literary field at the turn of the twentieth century, superimposing the political, the aesthetic, and the religious and connecting the question of literary form with that of the formation of French youth. The article also reassesses the survival of religion in twentieth-century French literature, and in particular the enduring religiosity inflecting both political modernity and modernist aesthetics.
“Unruly Vernacular Riverfront”: Eileen Myles's Queer Persistence in the Changing Climate of New York
Authors: Knittle Davy 
Published: October 2024

AbstractThis essay reads the poet Eileen Myles's recent turn to climate activism as an extension of their queer critique of predatory urban change on Manhattan's Lower East Side, where they have lived since the 1970s. Myles's climate activism opposes the demolition of Manhattan's East River Park to facilitate one of New York City's first large-scale climate resiliency projects. Myles argues that residents’ desires should shape climate resiliency planning priorities. I read Myles's earlier poems and essays to describe how the queer persistence and the attention to the “now” of urban change that they develop in response to New York's housing crisis in the 1980s during the early era of AIDS inform their climate activism. I argue that the environmental humanities tools needed to represent climate change on an urbanizing planet are inextricable from a queer theory approach to sustaining desire and loss amid precarity, as becomes apparent through Myles's writing.
Twyla Tharp’s Making Television Dance (1977) and the Technologized Dancing Body
Authors: Krayenbuhl Pamela 
Published: October 2024

This article looks at the technologized dancing body on television, particularly in videodance. It asks and begins to answer the question: What were emerging technologies of the late twentieth century able to do with, to, or for the dancing body that was not possible previously, and which built the foundation for the ways today’s digital technologies interface with the dancing body? In beginning to answer this question, the article closely examines Twyla Tharp's Making Television Dance (1977) and argues that Tharp's piece condenses and summarizes the experiments of videodance during the late twentieth century, highlighting its foundational shift from using technology to exclusively do things to the body or extract things from it, to instead using the body to interface with and demonstrate the capabilities of a new technology—​triggering the machine’s capabilities using the body’s cues. In other words, videodance reframes the body as a (technologized) tool. Ultimately, this article reveals that late 1960s and 1970s videodance was a transitional interstice between two more enduring forms of screendance: celluloid dance film and digital dance data.
Role of platelet-rich plasma as intraoperative adjunctive therapy in the surgical management of achilles tendinopathy: A comparative analysis review
Authors: Lakhani Amit , Pal Satinder 
Published: October 2024

Platelet-Rich Plasma (PRP) therapy has emerged as a promising treatment modality for Achilles tendinopathy, leveraging its growth factors to accelerate healing. PRP promotes tissue regeneration, inflammation control, collagen synthesis, and angiogenesis, making it a favorable option in both conservative and surgical management of the condition. Comparative studies show that patients treated with PRP report faster recovery, improved pain reduction, and enhanced functional outcomes compared to those who undergo standard treatments alone, such as physical therapy or corticosteroid injections. Furthermore, when used as an adjunct in surgical management, PRP enhances tendon healing by promoting fibroblast activity and reducing the risk of postoperative complications like re-tear and inflammation. Although the clinical outcomes vary across studies, a growing body of evidence suggests PRP's beneficial role in reducing recovery time and improving long-term functional outcomes in Achilles tendinopathy, both non-surgically and as an intraoperative adjunct.This article provides a balanced view of PRP's utility in Achilles tendinopathy treatment strategies.
Study of nutrient foramina in dry adult femur bones in a medical college from north India
Authors: Akhter Yasmeena , Fatima Kaneez , Bhat Ghulam Mohammad , Shah Bashir Ahmad , Ali Zameer 
Published: October 2024

Nutrient foramina are entry points of nutrient arteries in bones and form important landmarks on human bones. Understanding the nutrient foramina is critical to surgical practice. An insult to the nutrient foramina leads to devascularization of bone. The number, position, patency and direction of nutrient foramina are important in various surgical procedures and vary with race, ethnicity and geographical areas highlighting the importance of this study. The objective of the present study was to describe the number, position, direction, size, and foraminal index of nutrient foramen in the human adult femurs. : The present study was undertaken on 100 adult femur bones of both sexes and sides in government medical college in north India. Bones were studied with number, size, position, direction and patency of nutrient foramina.: 56% of femurs were right-sided and single foramina was seen in 75% of bones. In two-thirds of bones, nutrient foramina were found in upper two-thirds of femur and most common site of nutrient foramina was medial lip of Linea aspera. The direction of nutrient foramina was away from growing end in 95% of bones and in same percentage of bones nutrient foramina were found patent. The mean foraminal index for the femur bones was 40.8 with SD of 12.62 and mean length was 38.9cm with SD of 2.5cm.: The present study provides information on the number, size, position, and direction of nutrient foramina of the femur which is very in important in surgical approaches on femur.