bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sorting nexin 9 negatively regulates invadopodia formation and function in cancer cells
Authors: Bendris Nawal , Stearns Carrie J. S. , Reis Carlos R. , Rodriguez-Canales Jaime , Liu Hui , Witkiewicz Agnieszka W. , Schmid Sandra L. 
Published: June 2016

ABSTRACT
The ability of cancer cells to degrade the extracellular matrix and invade interstitial tissues contributes to their metastatic potential. We recently showed that overexpression of sorting nexin 9 (SNX9) leads to increased cell invasion and metastasis in animal models, which correlates with increased SNX9 protein expression in metastases from human mammary cancers. Here, we report that SNX9 expression is reduced relative to neighboring normal tissues in primary breast tumors, and progressively reduced in more aggressive stages of non-small-cell lung cancers. We show that SNX9 is localized at invadopodia where it directly binds the invadopodia marker TKS5 and negatively regulates invadopodia formation and function. SNX9 depletion increases invadopodia number and the local recruitment of MT1-MMP by decreasing its internalization. Together, these effects result in increased localized matrix degradation. We further identify SNX9 as a Src kinase substrate and show that this phosphorylation is important for SNX9 activity in regulating cell invasion, but is dispensable for its function in regulating invadopodia. The diversified changes associated with SNX9 expression in cancer highlight its importance as a central regulator of cancer cell behavior.
RiboProfiling: a Bioconductor package for standard Ribo-seq pipeline processing
Authors: Popa Alexandra , Lebrigand Kevin , Paquet Agnes , Nottet Nicolas , Robbe-Sermesant Karine , Waldmann Rainer , Barbry Pascal 
Published: June 2016

The ribosome profiling technique (Ribo-seq) allows the selective sequencing of translated RNA regions. Recently, the analysis of genomic sequences associated to Ribo-seq reads has been widely employed to assess their coding potential. These analyses led to the identification of differentially translated transcripts under different experimental conditions, and/or ribosome pausing on codon motifs. In the context of the ever-growing need for tools analyzing Ribo-seq reads, we have developed ‘RiboProfiling’, a new Bioconductor open-source package. ‘RiboProfiling’ provides a full pipeline to cover all key steps for the analysis of ribosome footprints. This pipeline has been implemented in a single R workflow. The package takes an alignment (BAM) file as input and performs ribosome footprint quantification at a transcript level. It also identifies footprint accumulation on particular amino acids or multi amino-acids motifs. Report summary graphs and data quantification are generated automatically. The package facilitates quality assessment and quantification of Ribo-seq experiments. Its implementation in Bioconductor enables the modeling and statistical analysis of its output through the vast choice of packages available in R. This article illustrates how to identify codon-motifs accumulating ribosome footprints, based on data from Escherichia coli.
Conversations in the American Newspaper «The New York Times» at the End of the XX Сentury
Authors: Маркина  , Markina Yulia 
Published: June 2016

In this article the author analyzes factors and social conditions that in the
1990s affected the transformation of the editorial policy of the «The New
York Times», one of the most respected and influential newspapers, not
only in the United States, but worldwide. The author of this article traced
trends and conditions of the development of American quality press that
turned «The New York Times» from strictly quality newspaper intended for
the intellectual elite and high-ranking officials in qualitative mass edition.
The publishers were forced to adapt to the wishes and sentiments of new
readers. Consequently, their decision was to simplify the official style of respectable
«The New York Times» paying more attention to the scandalous
articles and the criminal chronicle. The article also explores the thematic focus
of updated elite newspaper, addressed now not only to the rich people
of high society, but also to representatives of different social groups. The
subjects of this article are typological innovations in the newspaper related
to social, cultural, economic and political changes in the United States. The
purpose of the study is to analyze the above changes in content of the
newspaper’s publications.
Verbalization of Perceptual Experience in Russian Cordinative Constructions
Authors: Семенова  , Semenova N. 
Published: June 2016

The article is devoted to the peculiarities of verbalization of perceptual experience
in the syntactic constructions that actualize indefinite-temporal taxical
relation. In the author opinion, this meaning is always realized in coordinative
constructions, correlative asyndetic compound sentences and simple
sentences with homogeneous predicates when the latter are expressed by
verbs in the imperfective aspect and the subject – by a noun or pronoun in
the plural. Incidentally, it is specially emphasized that the subject need not
be explicit. The communicative effect of such sentences is in the fact that
giving a precise description of the actual or imaginary sequence of actions
is not very important for the speaker: what really matters is the speaker’s
own, subjective interpretation of a complex event. That is why the speaker
builds syntactic constructions of a particular kind, choosing specific lexicogrammatical
means.
CHARACTERIZING HIGH-TEMPERATURE DEFORMATION OF INTERNALLY HEATED NUCLEAR FUEL ELEMENT SIMULATORS
Authors: Belov Alexander I. , Fong Randy W.L. , Leitch Brian W. , Nitheanandan Thambiayah , Williams Anthony 
Published: June 2016

The sag behaviour of a simulated nuclear fuel element during high-temperature transients has been investigated in an experiment utilizing an internal indirect heating method. The major motivation of the experiment was to improve understanding of the dominant mechanisms underlying the element thermo-mechanical response under loss-of-coolant accident conditions and to obtain accurate experimental data to support development of 3-D computational fuel element models. The experiment was conducted using an electrically heated CANDU fuel element simulator. Three consecutive thermal cycles with peak temperatures up to ≈1000 °C were applied to the element. The element sag deflections and sheath temperatures were measured. On heating up to 600 °C, only minor lateral deflections of the element were observed. Further heating to above 700 °C resulted in an element multi-rate creep and significant permanent bow. Post-test visual and X-ray examinations revealed a pronounced necking of the sheath at the pellet-to-pellet interface locations. A wall thickness reduction was detected in the necked region that is interpreted as a sheath longitudinal strain localization effect. The sheath cross-sectioning showed signs of a “hard” pellet–cladding interaction due to the applied cycles. A 3-D model of the experiment was generated using the ANSYS finite element code. As a fully coupled thermal mechanical simulation is computationally expensive, it was deemed sufficient to use the measured sheath temperatures as a boundary condition, and thus an uncoupled mechanical simulation only was conducted. The ANSYS simulation results match the experiment sag observations well up to the point at which the fuel element started cooling down.
Point-of-care testing of activated clotting time in the ICU: is it relevant?
Authors: Brown Ellenora , Clarke Jody , Edward Karen-leigh , Giandinoto Jo-Ann 
Published: June 2016

Background:Over the past 50 years there have been significant advances in both the clinical techniques and equipment used in the intensive care environment. One traditionally used point-of-care test is activated clotting time (ACT), a coagulation test primarily used during cardiopulmonary bypass surgery to monitor the anticoagulation effects of heparin. The ACT test has since emerged into the intensive care environment to guide clinical assessment and management of haemostasis in postoperative cardiac patients.Objectives:The aim of this integrative systematic review was to critique the available research evaluating the effectiveness of ACT point-of-care testing in the intensive care unit for adult patients following cardiopulmonary bypass and cardiac surgery and any impacts this may have on nursing care.Methods:A systematic search of Medline, CINAHL and PubMed was undertaken.Results:The search identified five research papers reporting on the use of ACT point-of-care testing in the intensive care unit for adult cardiac surgical patients. Meta-analysis was not performed due to the lack of homogeneity between the papers included.Conclusions:There was a lack of clear evidence for the use of the ACT point-of-care test after cardiac surgery in the intensive care environment. This review has highlighted that conventional laboratory tests are generally more accurate and reliable than this point-of-care test in guiding nursing care management.
Arcade fever: Economics, affect and interface design of the 1970s and 1980s video arcade
Authors: Pullen Treva M. 
Published: June 2016

Abstract
How is it that the paradigm shift from mechanical to video-based arcade gaming has created a loyal video game following that holds true today? This article will explore the historical development of video arcade games, their instantaneous popularity and their continued presence in the world of contemporary gaming. In reading the affective experience of gaming through the lens of actor-network-theory (ANT), a number of factors can be specified for the popularity of nostalgic gaming: the affective design of interface, the emergent symbols of the arcade game, the spectacular nature of play, the mastery of a game (maximizing play per dollar spent), and the affective potential of precognitive actions and its relation to nostalgia. This leads to the conclusion that all these factors co-produce a wholly novel experience particular to the network of the arcade.
Pseudo-nature: A reading of Raze Bloom by Rachael Champion through the theories of Hannah Arendt
Authors: Moore Hattie 
Published: June 2016

Abstract
This article is a reading of Rachael Champion’s work Raze Bloom through the philosophy of Hannah Arendt, in her book The Human Condition. Focusing on the category of work and products of homo faber (the man-made world), with specific attention paid to the problematic relationship of humans with nature and the authority of science on the earth and human life.
Ontological shifts: Multi-sensoriality and embodiment in a third wave of digital interfaces
Authors: Davidson Andrea 
Published: June 2016

Abstract
Examining the ontology and place of digital dance within the spectrum of contemporary choreographic expression, this article proposes to consider the interweaving of interoceptive (somatic) and exteroceptive (technological) agency in a third wave of digital interfaces for dance. It argues that an ontology of digital dance might be summarily qualified as an active sensory-perceptual mode of experiencing, capable of revealing new dimensions of aesthetic reception, modes of performativity and expressions of corporeal presence in dance that emerge with/through the mediated body. It views technology not as a foreign, autonomous agency, system or simple tool, but rather as a means of stimulating heightened sensory awareness and forging relations with the individual’s somatic (inner) bodily experience. while referencing a range of recent works that establish the conditions for such experiences, it further proposes to consider how digital works develop and underscore perspective as a dramaturgical strategy and aesthetic, and as a consequence, how new media interfaces for dance can be considered ‘new viewing-sensing devices’.
Synthesis of some benzimidazole derivatives endowed with 1,2,3-triazole as potential inhibitors of hepatitis C virus
Authors: Youssif Bahaa G. M. , Mohamed Yaseen A. M. , Salim Mohammed T. A. , Inagaki Fuyuhiko , Mukai Chisato , Abdu-Allah Hajjaj H. M. 
Published: June 2016

Abstract
New derivatives of 2-thiobenzimidazole incorporating triazole moiety were synthesized, characterized and tested in vitro for antiviral activity against hepatitis C virus (HCV) and hepatitis B virus (HBV). Their cytotoxicity was determined by the reduction in the number of viable cell. All of the synthesized compounds are inactive against HBV and some showed activity against HCV. In particular, two compounds showed significant activity, 2-{4-[(1-benzoylbenzimidazol-2-ylthio)methyl]-1H-1,2,3-triazol-1-yl}-N-(p-nitro-phenyl)-acetamide (13) and 2-(4-{[1-(p-chlorobenzoyl)-benzimidazol-2-ylthio)methyl]-1H-1,2,3-triazol-1-yl}-N-(p-nitrophenyl)-acetamide (17). The results give an insight into the importance of the substituent at position 2 of benzimidazole for the inhibition of HCV.
Class Teachers – Their Thinking and Reasoning in the Context of Creating a Favourable Classroom Social Climate by Means of the Methods of Personal and Social Education
Authors: Geršicová Zuzana 
Published: June 2016

Abstract
The paper deals with class teachers’ thinking and reasoning processes and the possibilities of influencing teachers’ ability to create a favourable classroom social climate. This paper describes personal and social education as one of the means and methods of such influencing. The results of the research carried out indicate that teachers have a very high opinion regarding their ability to create a favourable classroom social climate. The issues of personal and social education in the work of a class teacher are the topic of the project KEGA 002DTI-4/2013 being solved by a team of professionals at Dubnica Institute of Technology in Dubnica nad Váhom.
Effect of Biopolishing On Warm–Cool Feeling of Knitted Fabric: A Subjective and An Objective Evaluations
Authors: Mangat Asif , Hes Lubos , Bajzik Vladimir 
Published: June 2016

Abstract
Soft and clean surface of fabric without any floating fibers is one of the factors important for better marketing of clothing. The most common method for having such clean fabric surface is the removal of protruding (floating) fiber from the surface of the fabric. Many studies have proved that enzymatic treatment, commonly called biopolishing, removes the floating fibers from the surface of fabric and gives a smooth surface to the fabric. This study is an effort to assess and measure the impact of biopolishing of knitted fabric through objective and subjective evaluation on warm-cool feeling of fabric because of change in surface profile of the fabric. For testing purposes, 31 knitted fabric samples of various kinds were produced. Alambeta has been used for measuring thermal absorptivity values of fabric. Thermal absorptivity is an indicator of warm-cool feeling. For subjective evaluation, a group of 30 people were asked to give their opinion about warm-cool feeling. Both subjective and objective assessments confirm that biopolishing has a significant impact on warm-cool feeling. Fabric gives cool feeling after biopolishing. This study explores that clean surface will have higher thermal absorptivity and will give cool feeling when it will be touched by human skin.
Improvment of Clothes Fit for Different Female Bodies
Authors: Surikova Olga V. , Kuzmichev Victor E. , Surikova Galina I. 
Published: June 2016

Abstract
The factors influencing for fit and suit of women’s clothing have been studied. The main reason of misfit is the nonconformity between the front and back width of pattern block, the corresponding body sizes taken across the hipline, and the textile materials properties. To predict the behavior of textile fabrics in real clothes including the shear deformation and wrinkles appearing, the special test and device have been designed. The developed method of pattern block making includes the test of clothes proportionality based on the female bodies sizes, pattern block indexes, and textile fabrics properties. Features of “figure-clothes” systems in-cluding the vertical designing lines, styles, volume of clothes, ease allowance and its distribution between the back, armhole, and front of the pattern blocks were taken into consideration. Recommendations in terms of selecting the proper design of style for different sizes of female bodies have been made.
Human Resources or Information Technology: What is More Important for Companies in the Digital Era?
Authors: Turulja Lejla , Bajgorić Nijaz 
Published: June 2016

Abstract

Background: Companies can improve their business performance, increase revenues and reduce costs by enhancing their information technology (IT) capability. On the other side, there is an increasing importance of human resource management (HRM) practices related to IT utilization, which are important for the business performance of a company in the rapidly changing knowledge-based economy.

Objectives: The objective of this paper is to analyze the relations among IT capability, HRM capability and the firm’s performance outcomes.

Methods/Approach: The paper uses survey data and Structural Equation Modeling to analyze the relationships among IT capability, HRM capability and firms’ performance.

Results: This paper reveals that IT capability to some extent determines firms’ business performance but it plays more important role in enhancing HRM capability. In addition, HRM capability significantly impacts business performance.

Conclusions: The findings indicate that managers should not focus on allocating resources only for IT investments. In order to achieve better business performances, these technologies need to be used to support all business processes including HRM activities.
Constant Proportion Portfolio Insurance Strategy in Southeast European Markets
Authors: Agić-Šabeta Elma 
Published: June 2016

Abstract

Background: In today’s highly volatile and unpredictable market conditions, there are very few investment strategies that may offer a certain form of capital protection. The concept of portfolio insurance strategies presents an attractive investment opportunity.

Objectives: The main objective of this article is to test the use of portfolio insurance strategies in Southeast European (SEE) markets. A special attention is given to modelling non-risky assets of the portfolio.

Methods/Approach: Monte Carlo simulations are used to test the buy-and-hold, the constant-mix, and the constant proportion portfolio insurance (CPPI) investment strategies. A covariance discretization method is used for parameter estimation of bond returns.

Results: According to the risk-adjusted return, a conservative constant mix was the best, the buy-and-hold was the second-best, and the CPPI the worst strategy in bull markets. In bear markets, the CPPI was the best in a high-volatility scenario, whereas the buy-and-hold had the same results in low- and medium-volatility conditions. In no-trend markets, the buy-and-hold was the first, the constant mix the second, and the CPPI the worst strategy. Higher transaction costs in SEE influence the efficiency of the CPPI strategy.

Conclusions: Implementing the CPPI strategy in SEE could be done by combining stock markets from the region with government bond markets from Germany due to a lack of liquidity of the government bond market in SEE.
Three-Dimensional Crane Modelling and Control Using Euler-Lagrange State-Space Approach and Anti-Swing Fuzzy Logic
Authors: Aksjonov Andrei , Vodovozov Valery , Petlenkov Eduard 
Published: June 2016

Abstract
The mathematical model of the three-dimensional crane using the Euler-Lagrange approach is derived. A state-space representation of the derived model is proposed and explored in the Simulink® environment and on the laboratory stand. The obtained control design was simulated, analyzed and compared with existing encoder-based system provided by the three-dimensional (3D) Crane manufacturer Inteco®. As well, an anti-swing fuzzy logic control has been developed, simulated, and analyzed. Obtained control algorithm is compared with the existing anti-swing proportional-integral controller designed by the 3D crane manufacturer Inteco®. 5-degree of freedom (5DOF) control schemes are designed, examined and compared with the various load masses. The topicality of the problem is due to the wide usage of gantry cranes in industry. The solution is proposed for the future research in sensorless and intelligent control of complex motor driven application.
PLC-Based Pressure Control in Multi-Pump Applications
Authors: Vodovozov Valery , Raud Zoja , Gevorkov Levon 
Published: June 2016

Abstract
The paper is devoted to the centrifugal pumps represented the most popular type of pumping equipment used in different areas. The pressure control approach for variable speed driven (VSD) parallel connected centrifugal pumps is reported. The goal of the study is optimization of some quality indices, such as efficiency, consumed power, productivity, energy carrier temperature, heat irradiation, etc. One of them – efficiency – has been studied in the paper more carefully. The mathematical model of pumping process is discussed and a vector-matrix description of the multi-pump application is given. The program-based pressure control system is developed which productivity is changed by regulating the number of working pumps. The paper introduces new pressure control algorithms based on the working point estimation intended for programmable logical controllers (PLC). Experiments prove correctness of the offered methodology.
Seasonal assessment, treatment and removal of heavy metal concentrations in a tropical drinking water reservoir
Authors: Mustapha Moshood Keke , Ewulum Joy Chinenye 
Published: June 2016

Abstract
Heavy metals are present in low concentrations in reservoirs, but seasonal anthropogenic activities usually elevate the concentrations to a level that could become a health hazard. The dry season concentrations of cadmium, copper, iron, lead, mercury, nickel and zinc were assessed from three sites for 12 weeks in Oyun reservoir, Offa, Nigeria. Triplicate surface water samples were collected and analysed using atomic absorption spectrophotometry. The trend in the level of concentrations in the three sites is site C > B > A, while the trend in the levels of the concentrations in the reservoir is Ni > Fe > Zn > Pb > Cd > Cu > Hg. Ni, Cd, Pb and Hg were found to be higher than the WHO guidelines for the metals in drinking water. The high concentration of these metals was from anthropogenic watershed run-off of industrial effluents, domestic sewages and agricultural materials into the reservoir coming from several human activities such as washing, bathing, fish smoking, especially in site C. The health effects of high concentration of these metals in the reservoir were highlighted. Methods for the treatment and removal of the heavy metals from the reservoir during water purification such as active carbon adsorption, coagulation-flocculation, oxidation-filtration, softening treatment and reverse osmosis process were highlighted. Other methods that could be used include phytoremediation, rhizofiltration, bisorption and bioremediation. Watershed best management practices (BMP) remains the best solution to reduce the intrusion of the heavy metals from the watershed into the reservoir.