bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular complication can be minimized with a balloon‐expandable, re‐collapsible sheath in TAVR with a self‐expanding bioprosthesis
Authors: Abu Saleh Walid K. , Tang Gilbert H.L. , Ahmad Hasan , Cohen Martin , Undemir Cenap , Lansman Steven L. , Reyes Manuel , Barker Colin M. , Kleiman Neal S. , Reardon Michael J. , Ramlawi Basel 
Published: November 2015

ObjectiveThis study evaluates the feasibility and safety of a balloon‐expandable, re‐collapsible sheath for TAVR patients, including those with small iliofemoral access (≤5.0 mm).BackgroundThe recommended iliofemoral diameter for the CoreValve TAVR system is ≥6.0 mm, but the lowest limit has not been determined.MethodsOf 322 consecutive patients who underwent TAVR from 1/2014 to 8/2015 at two institutions, 64 underwent transfemoral CoreValve implantation, using an 11/19‐French balloon‐expandable, re‐collapsible sheath, which has a 4.45 mm outer diameter (OD) on arterial entry, expands to 7.67 mm, then re‐collapses upon removal. Valve sizing and vascular access were determined by computed tomography, and outcomes were assessed using the Valve Academic Research Consortium 2 (VARC‐2) definitions.ResultsThirteen of 64 patients had a minimal iliofemoral artery luminal diameter (MLD) of ≤5.0 mm (mean 4.38+/−0.59 mm, range 3.1–5.0 mm), with vessel calcification ≤90° to 360° and tortuosity <45° to >90°. At the MLD point, the sheath‐to‐artery ratios, based on the fully expanded 7.67 mm OD, ranged 1.53–2.47, higher than previously reported ratios that risk vascular complications. Major comorbidities included chronic renal failure, severe chronic obstructive pulmonary disease, extreme thrombocytopenia, cirrhosis, prior cardiac surgery, poor ventricular function, and frailty. All 64 patients had TAVR with IV sedation and local anesthesia, with 0% sheath malfunction, 0% vascular complications, and 0% bleeding in‐hospital and at 30 days per VARC‐2 definitions.ConclusionsTAVR using a balloon‐expandable, re‐collapsible sheath is safe, including in small iliofemoral access ≤5.0 mm, thus considerably expanding the population suitable for transfemoral approach. © 2015 Wiley Periodicals, Inc.
Polynuclear Silver(I) Triazole Complexes: Ion Conduction and Nanowire Formation in the Mesophase
Authors: Su Padi Y. S. , Hsu S. J. , Tseng Jing C. W. , Hsu Hsiu‐Fu , Wang Wen‐Jwu , Lin Ivan J. B. 
Published: November 2015

AbstractExamples of polynuclear metallomesogens are few. Herein,1,2,4‐triazole ligands were used to prepare mono‐ and polynuclear silver(I) triazole metallomesogens. Besides showing an SmA phase in the mesophase, two interesting properties were observed. First, higher ion conductivity is always found for the polynuclear complexes than for the mononuclear complexes with the same anion, an observation contrary to the knowledge that migration of a monomeric cation should be faster than that of a polymeric cation. Second, thermolysis of the polynuclear silver(I) triazole complexes in the assembled mesophase yielded Ag nanowires, in an excellent demonstration of the assembled nature of the polynuclear silver(I) ions in the thermolysis process.
Dual Effect of Manganese Oxide Micromotors: Catalytic Degradation and Adsorptive Bubble Separation of Organic Pollutants
Authors: Wani Owies M. , Safdar Muhammad , Kinnunen Niko , Jänis Janne 
Published: November 2015

AbstractManganese oxide (MnO2) based micromotors exhibiting a dual effect, that is, catalytic degradation and adsorptive bubble separation, were employed for water remediation. The dual effect of MnO2 microparticles led to a greater than 90 % of decolorization of non‐biodegradable organic dyes in just 1 h, without the need for external agitation or bubble generation. These findings suggest high potential of MnO2 micromotors for decontamination of organic pollutants from wastewaters or natural water reserves.
Controlled Directional Motions of Molecular Vehicles, Rotors, and Motors: From Metallic to Silicon Surfaces, a Strategy to Operate at Higher Temperatures
Authors: Chérioux Frédéric , Galangau Olivier , Palmino Frank , Rapenne Gwénaël 
Published: November 2015

AbstractIn the last decade, many nanomachines with controlled molecular motions have been studied, mainly on metallic surfaces, which are easy to obtain very clean, and are stable over months. However, the studies of mechanical properties of nanomachines are mainly performed at very low temperatures, usually between 5 and 80 K, which prevents any kind of applications. In this Minireview, we will present our strategy to operate at higher temperatures, in particular through the use of semiconducting silicon surfaces. We also review our best achievements in the field through some examples of rotating molecular machines that have been designed, synthesized, and studied in our groups. On metallic surfaces, the nanovehicles are molecules with two or four triptycenes as wheels and the molecular motor is built around a ruthenium organometallic center with a piano‐stool geometry and peripheric ferrocenyl groups. On semiconducting silicon surfaces, vehicles are also made from triptycene fragments and the rotor is a pentaphenylbenzene molecule.
Electrocatalytic Oxidation of Amines by Ni­(1,4,8,11‐tetraazacyclotetradecane)2+ Entrapped in Sol–Gel Electrodes
Authors: Burg Ariela , Shamir Dror , Apelbaum Lina , Albo Yael , Maimon Eric , Meyerstein Dan 
Published: November 2015

AbstractNiL2+ (L = 1,4,8,11‐tetraazacyclotetradecane) was entrapped in sol–gel matrices in the presence of graphite. The matrices thus prepared serve as electrocatalysts for the oxidation of amines. The results point out that: (1) It is easy to prepare electrocatalytic electrodes by using this approach. (2) The properties of the electrodes thus prepared depend on the nature of the precursors used to prepare the matrices. (3) The mechanism of the electrocatalytic process differs from that observed in homogeneous solutions and depends on the nature of the electrode. (4) The matrix protects NiL2+ against the oxidation of the ligand.
The Effect of Medical Marijuana Laws on Body Weight
Authors: Sabia Joseph J. , Swigert Jeffrey , Young Timothy 
Published: November 2015

AbstractThis study is the first to examine the effects of medical marijuana laws (MMLs) on body weight, physical wellness, and exercise. Using data from the 1990 to 2012 Behavioral Risk Factor Surveillance System and a difference‐in‐difference approach, we find that the enforcement of MMLs is associated with a 2% to 6% decline in the probability of obesity. We find some evidence of age‐specific heterogeneity in mechanisms. For older individuals, MML‐induced increases in physical mobility may be a relatively important channel, while for younger individuals, a reduction in consumption of alcohol, a substitute for marijuana, appears more important. These findings are consistent with the hypothesis that MMLs may be more likely to induce marijuana use for health‐related reasons among older individuals, and cause substitution toward lower‐calorie recreational ‘highs’ among younger individuals. Our estimates suggest that MMLs induce a $58 to $115 per‐person annual reduction in obesity‐related medical costs. Copyright © 2015 John Wiley & Sons, Ltd.
Intrinsic membrane properties determine hippocampal differential firing pattern in vivo in anesthetized rats
Authors: Kowalski Janina , Gan Jian , Jonas Peter , Pernía‐Andrade Alejandro J. 
Published: November 2015

ABSTRACTThe hippocampus plays a key role in learning and memory. Previous studies suggested that the main types of principal neurons, dentate gyrus granule cells (GCs), CA3 pyramidal neurons, and CA1 pyramidal neurons, differ in their activity pattern, with sparse firing in GCs and more frequent firing in CA3 and CA1 pyramidal neurons. It has been assumed but never shown that such different activity may be caused by differential synaptic excitation. To test this hypothesis, we performed high‐resolution whole‐cell patch‐clamp recordings in anesthetized rats in vivo. In contrast to previous in vitro data, both CA3 and CA1 pyramidal neurons fired action potentials spontaneously, with a frequency of ∼3–6 Hz, whereas GCs were silent. Furthermore, both CA3 and CA1 cells primarily fired in bursts. To determine the underlying mechanisms, we quantitatively assessed the frequency of spontaneous excitatory synaptic input, the passive membrane properties, and the active membrane characteristics. Surprisingly, GCs showed comparable synaptic excitation to CA3 and CA1 cells and the highest ratio of excitation versus hyperpolarizing inhibition. Thus, differential synaptic excitation is not responsible for differences in firing. Moreover, the three types of hippocampal neurons markedly differed in their passive properties. While GCs showed the most negative membrane potential, CA3 pyramidal neurons had the highest input resistance and the slowest membrane time constant. The three types of neurons also differed in the active membrane characteristics. GCs showed the highest action potential threshold, but displayed the largest gain of the input‐output curves. In conclusion, our results reveal that differential firing of the three main types of hippocampal principal neurons in vivo is not primarily caused by differences in the characteristics of the synaptic input, but by the distinct properties of synaptic integration and input‐output transformation. © 2015 The Authors Hippocampus Published by Wiley Periodicals, Inc.
Spiro[3H‐pyrazole‐3,3′‐oxindoles] Derived from 1,2,3,4‐Tetrahydroquinoline
Authors: Mazaheri Fatemeh , Saatluo Bahman Ebrahimi , Baradarani Mehdi M. , Joule John A. 
Published: November 2015

AbstractAldol condensation of 5,6‐dihydro‐4H‐pyrrolo[3,2,1‐ij]quinoline‐1,2‐dione with aryl methyl ketones generates 3‐(aroylmethylidene)oxindoles, which react with hydrazine to generate tricyclic spiro[3H‐pyrazole‐3,3′‐oxindoles].
T2* relaxation time in Achilles tendinosis and controls and its correlation with clinical score
Authors: Gärdin Anna , Rasinski Pawel , Berglund Johan , Shalabi Adel , Schulte Helene , Brismar Torkel B. 
Published: November 2015

PurposeTo investigate if the T2* of Achilles tendons can discriminate between chronic Achilles tendinosis and healthy controls; to correlate with clinical score; to evaluate its short‐term repeatability; and to estimate minimal detectable change.Materials and MethodsTwenty patients, with chronic mid‐portion Achilles tendinosis, and 10 controls without history of Achilles tendon symptoms, were examined with a 3T MR scanner with a 3D flash ultrashort time to echo sequence with five different echo times. The sequence was run twice to test repeatability. The tendon border was delineated on axial slices at three different levels in the calculated T2* maps. The clinical severity of Achilles tendinosis was measured by a VISA‐A questionnaire.ResultsThere was a significant difference in mean T2* between symptomatic and control tendons (P < 0.001). In patients with unilateral symptoms no significant difference in T2* was found between symptomatic and contralateral asymptomatic tendons (P = 0.19). There was no significant correlation between clinical severity and T2* (r = –0.28, P = 0.22). The short‐term repeatability of T2* showed a coefficient of variation of 18%, a least significant change of 50%, and the intraclass correlation coefficient had an average consistency of 0.99.ConclusionT2* may help to differentiate between chronic Achilles tendinosis and healthy controls but was not associated with the clinical score. However, and notably, the reproducibility of the method was low and the number of patients was small. J. Magn. Reson. Imaging 2016;43:1417–1422.
Threshold voltage modeling for dual‐metal quadruple‐gate (DMQG) MOSFETs
Authors: Samoju Visweswara Rao , Tiwari Pramod Kumar 
Published: November 2015

SummaryIn this paper, a three‐dimensional (3D) model of threshold voltage is presented for dual‐metal quadruple‐gate metal‐oxide‐semiconductor field effect transistors. The 3D channel potential is obtained by solving 3D Laplace's equation using an isomorphic polynomial function. Threshold voltage is defined as the gate voltage, at which the integrated charge (Qinv) at the ‘virtual‐cathode’ reaches to a critical charge Qth. The potential distribution and the threshold voltage are studied with varying the device parameters like gate metal work functions, channel cross‐section, oxide thickness, and gate length ratio. Further, the drain‐induced barrier lowering has also been analyzed for different gate length ratios. The model results are compared with the numerical simulation results obtained from 3D ATLAS device simulation results. Copyright © 2015 John Wiley & Sons, Ltd.
Temporal variations in phosphorus fractions and phosphatase activities in rhizosphere and bulk soil during the development of Larix olgensis plantations
Authors: Chen Lixin , Zhang Chao , Duan Wenbiao 
Published: November 2015

AbstractMany studies have well reported nutrient deficiency and soil degradation focusing on soil N in pure plantations. However, few papers focused on soil P deficiency during pure plantation afforestation. We examined the variations in P fractions and phosphatase (P‐ase) activities in the rhizosphere and bulk soils in Larix olgensis plantations of 16, 23, 34, and 49 y. Correlation analysis was applied to identify the relationships between available P and other P fractions and P‐ase activities in the rhizosphere soil at different developmental stages. The stepwise regression models were established to explore their relationships with tree growth. The results showed that the deficiency of available P occurred in the rhizosphere micro‐region relative to the bulk soil in the 34‐ and 49‐y‐old stands, which was related to the lower acid phosphatase activity, the deficient Fe‐bound P, and occluded phosphate, as well as to soil pH in the rhizosphere soil during these periods. In addition, tree growth in the young and near‐mature stands was significantly correlated with soil P fractions, and the main P fractions closely related to tree growth were total P, organic P, available P and inorganic P, followed by Ca‐bound P and Fe‐bound P. The decreases in average DBH and average height growth in the near‐mature stand were related to the deficiency of available P in this period. Our results indicate that the development of Larix olgensis plantations affects the bioavailability of P through dynamic changes of P fractions and P‐ase activities, which provides a theoretical base in future afforestation with Larix olgensis plantations.
Effect of physicochemical parameters on the polygalacturonase of an Aspergillus sojae mutant using wheat bran, an agro‐industrial waste, via solid‐state fermentation
Authors: Demir Hande , Tari Canan 
Published: November 2015

AbstractBACKGROUNDPolygalacturonases (PGs) are valuable enzymes of the food industry; therefore it is of great importance to discover new and GRAS PG‐producing microbial strains. In this study, PG enzyme produced from a high PG activity producer mutant Aspergillus sojae using wheat bran at the flask scale under pre‐optimized conditions of solid‐state fermentation (SSF) was biochemically characterized.RESULTSThe crude PG enzyme showed optimum activity in the pH range 4.0–5.0 and was stable in the pH range 3.0–7.0. The optimum temperature for the PG was 40 °C and it retained 99% of its activity at 50 °C. The mutant A. sojae PG could preserve more than 50% of its stability between 25 and 50 °C, both for 30 and 60 min, and was found to be stable in the presence of most of the tested compounds and metal ions. The inactivation energy (Ed) was determined as 125.3 kJ mol−1. The enthalpy (ΔH*), free energy (ΔG*) and entropy (ΔS*) of inactivation were found to be stable with increasing temperature.CONCLUSIONThe mutant A. sojae PG could be suitable for the clarification (depectinization) of orange and grape juices and wine. © 2015 Society of Chemical Industry
A phase II study of neoadjuvant chemotherapy with S‐1 and cisplatin for stage III gastric cancer: KUGC03
Authors: Okabe Hiroshi , Hata Hiroaki , Ueda Shugo , Zaima Masazumi , Tokuka Atsuo , Yoshimura Tsunehiro , Ota Shuichi , Kinjo Yousuke , Yoshimura Kenichi , Sakai Yoshiharu ,   On behalf of the Kyoto University Surgical Oncology Group (KUSOG)
Published: November 2015

ObjectivesA multi‐center phase II study was conducted to evaluate the safety and efficacy of neoadjuvant chemotherapy (NAC) with S‐1 plus cisplatin for advanced gastric cancer.MethodsThe eligibility criteria were clinical T3/T4 or N2, not Stage IV. Patients received two 35‐day cycles of S‐1 plus cisplatin, and then underwent D2 gastrectomy. The primary endpoint was 3‐year progression free survival (PFS). Secondary endpoints were ratio of R0 resection, response rate, adverse events, and overall survival. A sample size of 49 was determined to have 80% power for detecting 15% improvement in the 3‐year PFS over 55% at a one‐sided alpha of 0.1.ResultsAmong 53 patients enrolled, 44 patients completed two cycles of NAC (83%), and 48 patients underwent R0 resection (91%). Postoperative complications occurred in 13 patients (26%). A pathological response was confirmed in 24 patients (45%), including four complete responses. The 3‐year PFS was 50.7%, while the 3‐year OS was 74.9%.ConclusionsAlthough the observed 3‐year PFS rate was worse than expected, NAC with S1 plus cisplatin was safe and led to a high rate of R0 resection. A randomized controlled trial is needed to make conclusions about the effectiveness of NAC in Japanese patients undergoing D2 resection. J. Surg. Oncol. 2016;113:36–41. © 2015 Wiley Periodicals, Inc.
Dual Gate Tunable and High Responsivity Graphene‐Based Field Effect Transistors
Authors: Soni Mahesh , Sharma Satinder Kumar , Soni Ajay 
Published: November 2015

SummaryThe output characteristics of a dual gated depletion mode, n‐channel graphene field effect transistor (n‐Gr‐FET) are simulated to understand the unipolar Ids–Vds behavior for different values of gate voltages, (Vback and Vtop). In our results, the saturated drain‐source current (Ids) varies from 0.001 to 100 µA/µm, 9 to 125 µA/µm and 16 to 135 µA/µm as Vback is varied from 5 to 40 V with correspondingly Vtop of 0, 2 and 10 volts. Consequently, there is four to eight times enhancement in estimated mobility for varying Vback from 5 to 40V. The unipolar saturation in Ids at higher values of Vds can be understood from the compensation of parallel Vds and transverse (Vback−Vtop) electric fields. Furthermore, the channel length modulation (increase in Ids for Vtop > 0) supported by the increase in mobility, is observed because of reverse junction formation at the vicinity of the drain and gate terminal. The results signify that the dual gated n‐Gr‐FET, at optimum Vback, modulates the unipolar characteristics in channel region. Thus, making n‐Gr‐FET a potential candidate to stipulate the demand of low power, high performance functionalities in nano‐electronic applications.
Electronic Properties of Cu‐Pd Ordered Alloys
Authors: Sharma Ramesh , Dwivedi Shalini , Sharma Yamini 
Published: November 2015

SummaryThe Cu‐Pd alloy, for Pd concentration greater than 50 at% has a distorted FCC structure, while for Pd less than 18 at%, has a L12 type structure. The electronic structure of Cu3Pd and CuPd3, which are the ordered alloys of the Cu‐Pd system are investigated by the FP‐LAPW method based on the density functional theory. The temperature dependence of the electrical resistivity and Seebeck coefficients has been interpreted in terms of band structures and density of states.
Phase Transition and Electro‐Optic Studies in Polymer Stabilized Blue Phase Liquid Crystal
Authors: Singh Arshdeep , Malik Praveen 
Published: November 2015

SummaryIn the present work, polymer stabilized blue phase liquid crystal have been prepared by mixing blue phase liquid crystal, mono‐functional monomer, bifunctional monomer and photo initiator in a weight ratio of 93.5:3:3:0.5 respectively. Blue phases, BP‐I and BP‐II were observed during heating and cooling cycles. Polymer stabilized blue phase having a temperature range of 14.8°C and Kerr constant 1.23 nm/V2 was observed. Hysteresis effect measured in the polymer stabilized blue phase liquid crystal was almost negligible.
Synthesis and Characterization of PVA/GO Nanocomposite Films
Authors: Gahlot Swati , Kulshrestha Vaibhav , Agarwal Garima , Jha Prafulla K. 
Published: November 2015

SummaryNanocomposite films of PVA (polyvinyl alcohol) with GO (graphene oxide) as organic filler have been synthesized successfully. GO was prepared through modified Hummers method and confirmed by SEM and XRD. Nanocomposites were prepared containing various weight amount of GO (0.1, 0.2 and 0.5%) within PVA matrix. Filmss are casted on clean glass plate through solution casting method and dried followed by. Further the investigation of thermal and mechanical as well as physicochemical properties of nanocomposites are done using respective analysis techniques. Electronic conductivity of the prepared Films are also measured. The value of electronic conductivity enhances as the GO content increases within polymer matrix. Thermal and mechanical analysis shows increment in stability with increasing GO content. Maximum electronic conductivity e.g. 1.95 × 10−2 Scm−1 was found for G‐5 (0.5%) films.
Silver Nanoparticles and Carbon Nanotubes Induced DNA Damage in Mice Evaluated by Single Cell Gel Electrophoresis
Authors: Awasthi Kumud Kant , Awasthi Anjali , Verma Rajbala , Soni Inderpal , Awasthi Kamlendra , John P. J. 
Published: November 2015

SummaryThe broad applications of silver nanoparticles (Ag NPs) and multi walled carbon nanotubes (MWCNTs) increase human exposure and thus the potential risk associated to their toxicity. Therefore, the genotoxic effects of these nanomaterials toward hepatic cells of mice were investigated. Ag NPs of size 10.0 ± 2.0 nm having spherical shape and acid functionalized MWCNTs of diameter 20–30 nm and length 5–50 μm were solubilized with water. This aqueous solution applied orally to mouse at two dose levels 50 and 100 mg/kg body weight for 28 days led to DNA damage in liver cells as comet tail length, tail moment and percent DNA in tail were found to be increased in dose dependent manner in both the nanomaterial groups. In summary, the results suggest that Ag NPs and MWCNTs of smaller size at low concentration cause cytotoxicity and genotoxicity leading to damage to DNA and other cellular components.
Predictive Models for Halogen‐bond Basicity of Binding Sites of Polyfunctional Molecules
Authors: Glavatskikh Marta , Madzhidov Timur , Solov'ev Vitaly , Marcou Gilles , Horvath Dragos , Graton Jérôme , Le Questel Jean‐Yves , Varnek Alexandre 
Published: November 2015

AbstractHalogen bonding (XB) strength assesses the ability of an electron‐enriched group to be involved in complexes with polarizable electrophilic halogenated or diatomic halogen molecules. Here, we report QSPR models of XB of particular relevance for an efficient screening of large sets of compounds. The basicity is described by pKBI2, the decimal logarithm of the experimental 1 : 1 (B : I2) complexation constant K of organic compounds (B) with diiodine (I2) as a reference halogen‐bond donor in alkanes at 298 K. Modeling involved ISIDA fragment descriptors, using SVM and MLR methods on a set of 598 organic compounds. Developed models were then challenged to make predictions for an external test set of 11 polyfunctional compounds for which unambiguous assignment of the measured effective complexation constant to specific groups out of the putative acceptor sites is not granted. At this stage, developed models were used to predict pKBI2 of all putative acceptor sites, followed by an estimation of the predicted effective complexation constant using the ChemEqui program. The best consensus models perform well both in cross‐validation (root mean squared error RMSE=0.39–0.47 logKBI2 units) and external predictions (RMSE=0.49). The SVM models are implemented on our website (http://infochim.u‐strasbg.fr/webserv/VSEngine.html) together with the estimation of their applicability domain and an automatic detection of potential halogen‐bond acceptor atoms.