bluuebunny/crossref_metadata_2025_split huggingface dataset:
Virtual Feedback Reference Tuning Using Closed Loop Step Response Data in Frequency Domain
Authors: MASUDA SHIRO , KONG XIANDA , UDAGATA KOKI , MATSUI YOSHIHIRO 
Published: September 2017

SUMMARYThe paper gives a controller tuning method using a virtual reference feedback tuning (VRFT) approach in frequency domain. While the original VRFT uses a data‐driven performance index based on input/output data directly, the proposed one derives a frequency domain performance index based on the Fourier transformation of one‐shot experimental input‐output data. The frequency domain performance index enables the optimal prefilter to be straightforwardly designed without using the spectral density of the collected input signal. Hence, the proposed one outperforms the original one when the input and output data are collected from the closed loop step response. The effectiveness of the proposed method is illustrated through a numerical example.
Proposal of an Encoded Marker for Working Robots: An Encoded Marker Easy to Detect in Various Positions and under Blur
Authors: KOBORI NORIMASA , DEGUCHI DAISUKE , IDE ICHIRO , MURASE HIROSHI 
Published: September 2017

SUMMARYIt is becoming important for working robots to be able to identify and pick objects in various tasks. As in the recent Amazon Picking Challenge, using a marker for the picking task is a more practicable approach. However, a common maker code for working robots does not exist so far. Conventional maker codes as represented by QR code or ARToolKit marker cannot be reliably detected from various viewpoints. Thus, in this paper, we propose a new encoded marker which is flexible to the marker's position and blur. The proposed marker can be detected by an approach based on the scale space theory independent from such conditions. In addition, the representation of data by M‐sequence makes the encoded marker robust to blur. Experimental results showed the effectiveness of the proposed marker compared to the ARToolKit marker. Since the marker is more robust against ground clutter noise, various positions of markers and blur, it is more practicable.
Geomorphology under ice streams: Moving from form to process
Authors: Stokes Chris R. 
Published: September 2017

AbstractIce streams are integral components of an ice sheet's mass balance and directly impact on sea level. Their flow is governed by processes at the ice‐bed interface which create landforms that, in turn, modulate ice stream dynamics through their influence on bed topography and basal shear stresses. Thus, ice stream geomorphology is critical to understanding and modelling ice streams and ice sheet dynamics. This paper reviews developments in our understanding of ice stream geomorphology from a historical perspective, with a focus on the extent to which studies of modern and palaeo‐ice streams have converged to take us from a position of near‐complete ignorance to a detailed understanding of their bed morphology. During the 1970s and 1980s, our knowledge was limited and largely gleaned from geophysical investigations of modern ice stream beds in Antarctica. Very few palaeo‐ice streams had been identified with any confidence. During the 1990s, however, glacial geomorphologists began to recognise their distinctive geomorphology, which included distinct patterns of highly elongated mega‐scale glacial lineations, ice stream shear margin moraines, and major sedimentary depocentres. However, studying relict features could say little about the time‐scales over which this geomorphology evolved and under what glaciological conditions. This began to be addressed in the early 2000s, through continued efforts to scrutinise modern ice stream beds at higher resolution, but our current understanding of how landforms relate to processes remains subject to large uncertainties, particularly in relation to the mechanisms and time‐scales of sediment erosion, transport and deposition, and how these lead to the growth and decay of subglacial bedforms. This represents the next key challenge and will require even closer cooperation between glaciology, glacial geomorphology, sedimentology, and numerical modelling, together with more sophisticated methods to quantify and analyse the anticipated growth of geomorphological data from beneath active ice streams. © 2017 The Authors. Earth Surface Processes and Landforms published by John Wiley & Sons Ltd.
Extreme chromosome 17 copy number instability is a prognostic factor in patients with gastroesophageal adenocarcinoma: A retrospective cohort study
Authors: Birkness Jacqueline E. , Spada Neal G. , Miller Caitlyn , Luketich James D. , Nason Katie S. , Sun Weijing , Davison Jon M. 
Published: September 2017

AbstractGastric and esophageal cancers frequently show genomic instability and aneuploidy. Chromosomal copy number instability (CIN) is a form of genomic instability that exerts pleiotropic effects on cellular biology and is a source of genetic heterogeneity in a population of cells. CIN results in cell‐to‐cell variation in chromosome copy number which can be detected and quantified by fluorescence in situ hybridization (FISH). CIN is a biomarker associated with differential response to a number of chemotherapy compounds. We quantified chromosome 17 copy number instability (CIN‐17) in 348 gastroesophageal adenocarcinomas by centromeric FISH in cases that were tested for HER2 amplification. We evaluated the association between CIN‐17 and clinical outcome after surgical and nonsurgical treatment. CIN‐17 was detected in 45.4% (158/348) and extreme CIN‐17 in 28.4% (99/348). Extreme CIN‐17 had no association with outcome in surgically treated patients. However, in patients treated with conventional radiation and/or chemotherapy, extreme CIN‐17 was associated with 55% reduction in overall mortality (hazard ratio, 0.448; 95% confidence interval, 0.263–0.763) after adjusting for age and clinical stage at diagnosis. Extreme CIN‐17 is detected in over a quarter of gastroesophageal adenocarcinomas and is a favorable prognostic marker in patients treated nonoperatively.
Analysis of cancer gene expression data with an assisted robust marker identification approach
Authors: Chai Hao , Shi Xingjie , Zhang Qingzhao , Zhao Qing , Huang Yuan , Ma Shuangge 
Published: September 2017

ABSTRACTGene expression (GE) studies have been playing a critical role in cancer research. Despite tremendous effort, the analysis results are still often unsatisfactory, because of the weak signals and high data dimensionality. Analysis is often further challenged by the long‐tailed distributions of the outcome variables. In recent multidimensional studies, data have been collected on GEs as well as their regulators (e.g., copy number alterations (CNAs), methylation, and microRNAs), which can provide additional information on the associations between GEs and cancer outcomes. In this study, we develop an ARMI (assisted robust marker identification) approach for analyzing cancer studies with measurements on GEs as well as regulators. The proposed approach borrows information from regulators and can be more effective than analyzing GE data alone. A robust objective function is adopted to accommodate long‐tailed distributions. Marker identification is effectively realized using penalization. The proposed approach has an intuitive formulation and is computationally much affordable. Simulation shows its satisfactory performance under a variety of settings. TCGA (The Cancer Genome Atlas) data on melanoma and lung cancer are analyzed, which leads to biologically plausible marker identification and superior prediction.
Geochronological and geochemical signatures of the granitic rocks emplaced at the north‐eastern fringe of the Eastern Dharwar Craton, South India: Implications for late Archean crustal growth
Authors: Mukherjee Sneha , Ghosh Gautam , Das Kaushik , Bose Sankar , Hayasaka Yasutaka 
Published: September 2017

Geochemical and zircon U–Pb age data on granites of the Chitrial area, situated at the NE part of the Eastern Dharwar Craton, are presented to elucidate their petrogenesis, time(s) of emplacement, and role in crust formation. Based on field and geochemical characters, these granites are classified as alkali feldspar/monzo‐granite. Whole‐rock data of selected samples show evolved calc‐alkaline and peraluminous characters with high SiO2, K2O, large‐ion lithophile element, and light rare earth elements (LREE), depleted heavy rare earth elements (HREE) and strongly negative Eu anomaly. One sample shows slightly different character with low SiO2, enriched light rare earth elements, and depleted heavy rare earth elements without Eu anomaly. Geochemical analyses suggest that the rocks are S‐type granite with syn‐collisional and volcanic arc signatures. These granites define a coherent trend favouring low pressure crystallization of the magma. U–Pb zircon data show that the crystallization ages of the granites vary within 2514 ± 10 to 2525 ± 24 Ma. The geodynamic evolution of the Eastern Dharwar Craton is discussed wherein subduction and deep burial of sediment is envisaged to cause partial melting and granite genesis in the craton.
Autologous peripheral blood stem cell transplantation and the role of lenalidomide in patients affected by poems syndrome
Authors: Autore Francesco , Innocenti Idanna , Luigetti Marco , Piccirillo Nicola , Sora Federica , Chiusolo Patrizia , Sica Simona , Bacigalupo Andrea , Laurenti Luca 
Published: September 2017

AbstractPOEMS syndrome is a rare paraneoplastic condition, with a poorly understood pathogenesis. High dose chemotherapy followed by autologous stem cell transplantation (ASCT) has been reported to be an effective therapeutic option for patients with good performance status. Here, we review the role of ASCT for POEMS syndrome and discuss indications together with advantages and disadvantages, and related issues such lenalidomide given before or after ASCT, VEGF levels as a marker of disease, and different regimens for stem cell mobilization.
Three‐dimensional boundary layer flow over a rotating disk with power‐law stretching in a nanofluid containing gyrotactic microorganisms
Authors: Chen Hui , Chen Jiayang , Geng Yao , Chen Kai 
Published: September 2017

AbstractThe nanofluid model containing microorganisms over a rotating disk with power‐law stretching is constructed in this paper. The combined effects of nanoparticles and microorganisms in nanofluid are investigated by solving the governing equations numerically. The numerical solutions of the skin friction coefficient and local Nusselt number are in agreement with the corresponding previously published results. The quantities of physical interest are graphically presented and discussed in detail. It is found that the power‐law stretching index has produced profound influence on the flow as well as the heat and mass transfer.
Patterns in the linkage of water quantity and quality during low‐flows
Authors: Hellwig Jost , Stahl Kerstin , Lange Jens 
Published: September 2017

AbstractThis study investigates 72 catchments across the federal state of Baden‐Wuerttemberg, Germany, for changes in water quality during low‐flow events. Data from the state's water quality monitoring network provided seven water quality parameters (water temperature, electrical conductivity, concentrations of chloride, sodium, sulfate, nitrate, and phosphate), which were statistically related to streamflow variability. Water temperature changes during low‐flow showed seasonal dependence. Nitrate concentrations revealed high spatial heterogeneity with about one third of the stations showing decreasing values during low discharge. For most other parameters, concentrations increased during low‐flow. Despite consistent trend directions, the magnitudes of changes with streamflow differed markedly across the state. Both multiple linear regression and a multiple analysis of variances were applied to explain these differences with the help of catchment characteristics. Results indicated that for sulfate and conductivity, geology of the catchments was the most important control, whereas for chloride, sodium, and nitrate, sewage treatment plants had the largest influence. For phosphate, no clear control could be identified. Independent from the applied method, land use was a less important control on river water quality during low‐flow than geology or inflow from sewage treatment plants. These results show that the effects of diffuse and point sources, as well as those of natural and anthropogenic sources differ for different water quality parameters. Overall, a high diversity of potential water quality deterioration signals needs to be considered when the ecological status of rivers is to be protected during low‐flow events.
Modelling impacts of agricultural practice on flood peaks in upland catchments: An application of the distributed TOPMODEL
Authors: Gao Jihui , Holden Joseph , Kirkby Mike 
Published: September 2017

AbstractUpland agricultural land management activities such as grazing, vegetation burning, and bare ground restoration impact hydrological elements of headwater catchments, many of which may be important for downstream flood peaks (e.g., overland flow and soil water storage). However, there is poor understanding of how these management practices affect river flow peaks during high magnitude rainfall events. Using the distributed TOPMODEL, spatial configurations of land management were modelled to predict flood response in an upland catchment, which contains different regions operating subsidized agricultural stewardship schemes. Heavy grazing leading to soil compaction and loss of vegetation cover in stewardship regions covering 79.8% of the catchment gave a 42‐min earlier flow peak, which was 82.2% higher (under a 1‐hr 15‐mm storm) than the current simulated hydrograph. Light grazing over the same regions of the catchment had much less influence on river flow peaks (18 min earlier and 32.9% increase). Rotational burning (covering 8.8% of the catchment), most of which is located in the headwater areas, increased the peak by 3.2% in the same rainfall event. Vegetation restoration with either Eriophorum or Sphagnum (higher density) in bare areas (5.8%) of the catchment provided a reduction of flood peak (3.9% and 5.2% in the 15‐mm storm event), whereas the same total area revegetated with Sphagnum in riparian regions delivered a much larger decrease (15.0%) in river flow peaks. We show that changes of vegetation cover in highly sensitive areas (e.g., near‐stream zones) generate large impacts on flood peaks. Thus, it is possible to design spatially distributed management systems for upland catchments, which reduce flood peaks while at the same time ensuring economic viability for upland farmers.
Local delivery of strontium ranelate promotes regeneration of critical size bone defects filled with collagen sponge
Authors: Masalskas Bárbara Furtado , Martins Júnior Walter , Leoni Graziela Bianchi , Faloni Ana Paula de Souza , Marcaccini Andrea Márcia , Silva Sousa Yara Teresinha Corrêa , Castro‐Raucci Larissa Moreira Spinola de 
Published: September 2017

AbstractThe effect of local delivery of strontium ranelate (SR) on bone regeneration of critical size bone defects filled with collagen sponge was evaluated. Bone defects of 5 mm diameter created in rat calvaria were filled with collagen sponge (C); collagen sponge with 5 mM Sr2+ SR (C5SR) or collagen sponge with 50 mM Sr2+ SR (C50SR). After 2, 4, and 6 weeks, bone volume (BV), bone surface (BS), trabecular thickness (Tb.Th), trabecular number (Tb.N), and trabecular separation (Tb.Sp) were evaluated by computed microtomography. At 6 weeks, histological analysis was performed. Intragroup comparisons were made by the Friedman test, while comparisons between groups were made by Kruskal‐Wallis test (α = 5%). All groups showed increased BV, BS, Tb.Th, and Tb.N over time, but only C50SR promoted the reduction of Tb.Sp (p < 0.05). No significant differences between groups were detected at weeks 2 and 4. However, C50SR showed the highest values of BV, BS, and Tb.Th at 6 weeks (p < 0.05). Histological analysis revealed connective tissue in C and C5SR and immature bone tissue in C50SR. Local delivery of SR 50 mM Sr2+ associated with collagen sponge increased and accelerated bone regeneration in critical bone defects. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 333–341, 2018.
Hyaluronan incorporation into model contact lens hydrogels as a built‐in lubricant: Effect of hydrogel composition and proteoglycan 4 as a lubricant in solution
Authors: Samsom Michael , Korogiannaki Myrto , Subbaraman Lakshman N. , Sheardown Heather , Schmidt Tannin A. 
Published: September 2017

AbstractContact lens friction significantly correlates with subjective comfort. Hyaluronan (HA) and proteoglycan 4 (PRG4) are natural boundary lubricants present in the body. The objective of this study was to assess the effect of crosslinked HA into the bulk of model contact lens materials pHEMA, pHEMA/TRIS, and DMAA/TRIS on surface wettability, protein sorption, and boundary lubricating properties at a material–cornea biointerface, both alone and synergistically with PRG4 in solution. Surface wettability was assessed by water contact angle measurement, protein sorption by lysozyme sorption assay, and boundary lubricating properties using an in vitro friction test method. HA incorporation (HAinc) increased the surface wettability of all materials, and reduced protein sorption for pHEMA and DMAA/TRIS. HAinc increased friction for pHEMA, and DMAA/TRIS, whereas a decrease was observed for pHEMA/TRIS. A combination of HAinc and PRG4sol had a synergistic effect of reducing friction only for pHEMA/TRIS. This combination had similar friction reduction compared with PRG4sol alone for DMAA/TRIS. These results indicate HA incorporation could be an effective internal wetting agent, antiadhesive, and boundary lubricant for pHEMA/TRIS silicone hydrogels. In conclusion, HA incorporation can reduce friction of hydrogels alone and in combination with PRG4 in solution, though in a hydrogel composition‐dependent (e.g., TRIS) manner. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1818–1826, 2018.
The incidence of sarcopenia among hospitalized older patients: results from the Glisten study
Authors: Martone Anna Maria , Bianchi Lara , Abete Pasquale , Bellelli Giuseppe , Bo Mario , Cherubini Antonio , Corica Francesco , Di Bari Mauro , Maggio Marcello , Manca Giovanna Maria , Marzetti Emanuele , Rizzo Maria Rosaria , Rossi Andrea , Volpato Stefano , Landi Francesco 
Published: September 2017

AbstractBackgroundNew evidence is emerging on the importance of lean body mass during periods of illness and recovery. The preservation of lean body mass during such periods of intense stress impacts both patient and treatment outcomes. However, data concerning the incidence of sarcopenia among older people during hospitalization are scarce. The objective of this study was to evaluate the development of sarcopenia in a sample of hospitalized older subjects.MethodsWe used data of 394 participants from the multicentre Italian Study conducted by the Gruppo Lavoro Italiano Sarcopenia—Trattamento e Nutrizione (GLISTEN) in 12 Acute Care Wards (Internal Medicine and Geriatrics) of University Hospitals across Italy. This study was designed to determine the prevalence of sarcopenia at hospital admission and the change in muscle mass and strength during hospitalization. Sarcopenia was defined as low skeletal mass index (kg/m2) along with either low handgrip strength or slow walking speed [European Working Groups on Sarcopenia in Older People (EWGSOP) criteria]. Estimation of skeletal muscle mass was performed by bioelectrical impedance analysis (BIA).ResultsThe mean age of the 394 enrolled patients (including 211 females who accounted for 53% of the sample) was 79.6 ± 6.4 years. Among those without sarcopenia at hospital admission, 14.7% of the study sample met the EWGSOP sarcopenia diagnostic criteria at discharge. The incidence of sarcopenia during hospitalization was significantly associated with the number of days spent in bed but was not correlated with the total length of hospital stay. In particular, patients who developed sarcopenia spent an average of 5.1 days in bed compared with 3.2 days for those with no sarcopenia at discharge (P = 0.02). Patients with sarcopenia showed a significantly lower body mass index compared with non‐sarcopenic peers (25.0 ± 3.8 kg/m2 vs. 27.6 ± 4.9 kg/m2, respectively; P < 0.001). Similarly, the skeletal mass index at admission was significantly lower among patients who developed sarcopenia during hospital stay.ConclusionsIncident sarcopenia during hospital stay is relatively common and is associated with nutritional status and the number of days of bed rest.
Ovarian structure and oogenesis of the extremophile viviparous teleostPoecilia mexicana(Poeciliidae) from an active sulfur spring cave inSouthernMexico
Authors: Torres‐Martínez Aarón , Hernández‐Franyutti Arlette , Uribe Mari Carmen , Contreras‐Sánchez Wilfrido Miguel 
Published: September 2017

AbstractThe structure of the ovary and oogenesis ofPoecilia mexicanafrom an active sulfur spring cave is documented.Poecilia mexicanais the only poeciliid adapted to a subterranean environment with high hydrogen sulfide levels and extreme hypoxic conditions. Twenty females were captured throughout one year at Cueva del Azufre, located in the State of Tabasco in Southern Mexico. Ovaries were processed with histological techniques.P. mexicanahas a single, ovoid ovary with ovigerous lamella that project to the ovarian lumen. The ovarian wall presents abundant loose connective tissue, numerous melanomacrophage centers and large blood vessels, possibly associated with hypoxic conditions. The germinal epithelium bordering the ovarian lumen contains somatic and germ cells forming cell nests projecting into the stroma.P. mexicanastores sperm in ovarian folds associated with follicles at different developmental phases. Oogenesis inP. mexicanaconsisted of the following stages: (i) oogonial proliferation, (ii) chromatin nucleolus, (iii) primary growth, subdivided into: (a) one nucleolus, (b) multiple nucleoli, (c) droplet oils‐cortical alveoli steps; (iv) secondary growth, subdivided in: (a) early secondary growth, (b) late secondary growth, and (c) full grown. Follicular atresia was present in all stages of follicular development; it was characterized by oocyte degeneration, where follicle cells hypertrophy and differentiate in phagocytes. The ovary and oogenesis are similar to these seen in other poeciliids, but we found frequent atretic follicles, melanomacrophage centers, reduced fecundity and increased of offspring size.