bluuebunny/crossref_metadata_2025_split huggingface dataset:
No need to look, trust me! Mutual trust and distrust in the European arrest warrant system
Authors: Bonelli Matteo , Correia de Carvalho Mateus 
Published: October 2024

AbstractNo cooperative scheme in EU law has displayed bigger tensions between mutual trust and fundamental rights protection than the EAW system. Despite the requirement developed by the CJEU for national courts to trust each other and recognise each other’s arrest warrants, the reality on the ground has shown high levels of distrust between national courts regarding Member States’ alignment with core EU values. In this contribution, we analyze how the CJEU has managed such tensions in the EAW system. To that effect, we first put the Court’s EAW case law into context by examining the broader language of mutual trust used by the Court in other fields of EU law. In doing so, we point out how the Court has espoused different levels of lawful distrust to be exercised in different circumstances under the scope of application of mutual trust. Given that broader context, it is contradictory for the Court to mainly view mutual trust as a requirement rather than a reality in need of permanent and continuing justification between national authorities. The latter conception of mutual trust is more apt to be the basis of EU horizontal cooperation, which must be value-based and sincere according to the Treaties. Therefore, we propose a bidimensional account of mutual trust as a legal principle, one that accommodates both trust and distrust as tools for managing the uncertainty and dynamic nature of trust-based cooperation. Finally, we explore how such account of mutual (dis)trust can be concretised by the Court and other political institutions.
A constitutional perspective on EU arms controls: mediating trade, security, and humanitarian responsibility
Authors: Vroege Bram 
Published: October 2024

AbstractThis article examines how European Union (EU) arms control measures are tailored to its constitutional foundations. EU Member States subject shipments of arms and components to controls so as to screen them for risks and potentially block them. In this context different Member States may make different geopolitical and humanitarian risk assessments. Existing EU measures have achieved only limited security screening harmonisation, and have left room for Member States to shirk their obligations under international humanitarian law. But in case of joint arms production, which the EU subsidises to become more autonomous, one Member State’s arms controls may block another State’s exports and thereby jeopardise cooperation. This article posits that any reform of EU arms controls should start by re-evaluating their present legal basis. A constitutional competence analysis shows that controls on arms shipments to non-EU states should be regulated in part through the Common Commercial Policy (CCP), and not just through the Common Foreign and Security Policy (CFSP). This would be consistent with other EU regulatory regimes for trade security. While a joint CFSP-CCP approach cannot fully prevent conflict, since this would require further foreign policy harmonisation, it could help foster security convergence and strengthen humanitarian due diligence mechanisms.
Elevated BCAA catabolism reverses the effect of branched-chain ketoacids on glucose transport in mTORC1-dependent manner in L6 myotubes
Authors: Mann Gagandeep , Adegoke Olasunkanmi A. John 
Published: October 2024

Abstract
Plasma levels of branched-chain amino acids (BCAA) and their metabolites, branched-chain ketoacids (BCKA), are increased in insulin resistance. We previously showed that ketoisocaproic acid (KIC) suppressed insulin-stimulated glucose transport in L6 myotubes, especially in myotubes depleted of branched-chain ketoacid dehydrogenase (BCKD), the enzyme that decarboxylates BCKA. This suggests that upregulating BCKD activity might improve insulin sensitivity. We hypothesised that increasing BCAA catabolism would upregulate insulin-stimulated glucose transport and attenuate insulin resistance induced by BCKA. L6 myotubes were either depleted of BCKD kinase (BDK), the enzyme that inhibits BCKD activity, or treated with BT2, a BDK inhibitor. Myotubes were then treated with KIC (200 μM), leucine (150 μM), BCKA (200 μM), or BCAA (400 μM) and then treated with or without insulin (100 nM). BDK depletion/inhibition rescued the suppression of insulin-stimulated glucose transport by KIC/BCKA. This was consistent with the attenuation of IRS-1 (Ser612) and S6K1 (Thr389) phosphorylation but there was no effect on Akt (Ser473) phosphorylation. The effect of leucine or BCAA on these measures was not as pronounced and BT2 did not influence the effect. Induction of the mTORC1/IRS-1 (Ser612) axis abolished the attenuating effect of BT2 treatment on glucose transport in cells treated with KIC. Surprisingly, rapamycin co-treatment with BT2 and KIC further reduced glucose transport. Our data suggests that the suppression of insulin-stimulated glucose transport by KIC/BCKA in muscle is mediated by mTORC1/S6K1 signalling. This was attenuated by upregulating BCAA catabolic flux. Thus, interventions targeting BCAA metabolism may provide benefits against insulin resistance and its sequelae.
Chinese word segmentation with heterogeneous graph convolutional network
Authors: Tang Xuemei , Su Qi , Wang Jun 
Published: October 2024

Abstract
Recently, deep learning methods have achieved remarkable success in the Chinese word segmentation (CWS) task. Some of them enhance the CWS model by utilizing contextual features and external resources (e.g., sub-words, lexicon, and syntax). However, existing approaches fail to fully use the heterogeneous features and their structural information. Therefore, in this paper, we propose a heterogeneous information learning framework for CWS, named heterogeneous graph neural segmenter (HGNSeg), which exploits heterogeneous features with the graph convolutional networks and the pretrained language model. Experimental results on six benchmark datasets (e.g., SIGHAN 2005 and SIGHAN 2008) confirm that HGNSeg can effectively improve the performance of CWS. Importantly, HGNSeg also demonstrates an excellent ability to alleviate the out-of-vocabulary (OOV) issue in cross-domain scenarios.
A Brave New World Out of the Same Old Pieces: Property Confiscation and Distribution in Postwar Czechoslovakia
Authors: Hoření Karina 
Published: October 2024

Abstract
This article deals with the confiscation of property from the German-speaking inhabitants of Czechoslovakia and its redistribution to the new settlers of the Czech borderlands. It shows how the social revolution—that is, the emergence of an egalitarian postwar society—was made possible by the national revolution—that is, the expulsion of the German-speaking inhabitants of Central Europe. Using the example of the industrial center of Liberec in northern Bohemia, the author shows how the Czech administration that was established after the Second World War applied the dichotomy of the Czech–German conflict to an ethnically complex postwar society and how, despite the ideology of distributing property to the “Slavs,” non-Czech minorities were discriminated against with respect to redistribution. Eventually, she analyzes how postwar Czechoslovak society was shaped, with an emphasis on the material demands of workers and collectives, even as individuals sought to achieve a middle-class lifestyle through participation in property distribution.
What are the changes in mothers’ diets after the birth of a child: results from the NutriNet-Santé cohort
Authors: Brunin Joséphine , Baudry Julia , Allès Benjamin , Ghozal Manel , Touvier Mathilde , Hercberg Serge , Lairon Denis , de Lauzon Guillain Blandine , Kesse-Guyot Emmanuelle 
Published: October 2024

AbstractChildbirth is a major life-changing event, this period is an opportunity to improve eating habits. The aim of this longitudinal study was to identify and characterise dietary changes in women according to their parity status. Dietary intake data from 4194 women of childbearing age included in the NutriNet-Santé cohort were derived using a FFQ, administered in 2014 and 2018, distinguishing between organic and conventional food consumption. Women were classified into four groups: ‘previous children’, ‘multiparous’, ‘primiparous’ and ‘nulliparous’. Multi-adjusted ANCOVA models were used to estimate the changes according to the parity group. Changes in food consumption towards a more plant-based, healthier and organic diet were observed in all four groups of women, although to various degrees. In multivariable models, ‘Nulliparous’ women showed a greater improvement in terms of ‘sustainable’ food consumption than ‘previous children’ women. ‘Primiparous’ women significantly increased their energy intake (+349 (269–429) kcal/d) and their consumption of dairy products (+30 (3–56) g/d), and they significantly decreased their consumption of alcohol (–23 (–32–15) g/d), coffee and tea (–107 (–155–60) g/d). Regarding organic food, ‘nulliparous’ women increased their consumption more than ‘previous children’ and ‘primiparous’ women were those who were most frequently in the top quintile of organic food increase. Although there were dietary changes in all groups of women according to their parity, childless women have a shift moving towards a more sustainable diet. Women who had a first child reduced their alcohol and caffeine consumption.
Serum concentrations of lipids, ketones and acylcarnitines during the postprandial and fasting state: the Postprandial Metabolism (PoMet) study in healthy young adults
Authors: Anfinsen Åslaug Matre , Myklebust Vilde Haugen , Johannesen Christina Osland , Christensen Jacob Juel , Laupsa-Borge Johnny , Dierkes Jutta , Nygård Ottar , McCann Adrian , Rosendahl-Riise Hanne , Lysne Vegard 
Published: October 2024

AbstractTo improve the interpretation and utilisation of blood lipids, ketones and acylcarnitine concentrations as biomarkers in clinical assessments, more information is needed on their dynamic alterations in response to dietary intake and fasting. The aim of this intervention study was to characterise the changes in serum lipid, ketone and acylcarnitine concentrations 24 h after a standardised breakfast meal. Thirty-four healthy subjects (eighteen males and sixteen females) aged 20–30 years were served a breakfast meal (∼500 kcal, 36 E% fat, 46 E% carbohydrates, 16 E% protein, 2E% fibre), after which they consumed only water for 24 h. Blood samples were drawn before and at thirteen standardised timepoints after the meal. Metabolite concentrations were plotted as a function of time since the completion of the breakfast meal. Results demonstrated that concentrations of HDL-cholesterol and LDL-cholesterol decreased until ∼2 h (–4 % for both), while TAG concentrations peaked at 3 h (+27 %). Acetoacetate and β-hydroxybutyrate were highest 24 h after the meal (+433 and +633 %, respectively). Acetylcarnitine, butyrylcarnitine, hexanoylcarnitine, octanoylcarnitine, decanoylcarnitine and dodecanoylcarnitine reached the lowest values at 60 min (decreases ranging from –47 to –70 %), before increasing and peaking at 24 h after the meal (increases ranging from +86 to +120 %). Our findings suggest that distinguishing between fasting and non-fasting blood samples falls short of capturing the dynamics in lipid, ketone, carnitine and acylcarnitine concentrations. To enhance the utility of serum acylcarnitine analyses, we strongly recommend accounting for the specific time since the last meal at the time of blood sampling.
‘He laid His hand upon both’: Self-punishment, vicarious punishment and Gregory's spirituality of the cross in the Moralia in Job
Authors: Underhill Tom 
Published: October 2024

AbstractGregory the Great's Moralia in Job has been said to mark a transitional phase in the development of atonement doctrine. I argue that the Moralia cohesively portrays Christ's redemptive work as achieving something in two directions: towards God, a vicarious payment of humanity's debt of punishment; towards humanity, an efficaciously convicting and restorative example. This sustains a spirituality in which exacting and self-denying moral effort rests on freedom from judgement and on the death accomplished by the Mediator. Engaging the Moralia in this manner illuminates patristic exegetical sensibilities and proves instructive about how the fathers fit into later taxonomies of atonement models.
Intestinal Parasitic Infection in Roman Britain: Integrating New Evidence from Roman London
Authors: Ledger Marissa L. , Redfern Rebecca , Mitchell Piers D. 
Published: October 2024

ABSTRACTThe aim of this study is to estimate the minimum prevalence of intestinal parasites in the population of Roman London through analysis of pelvic sediment from 29 third- to fourth-century burials from the 1989 excavations of the western cemetery at 24–30 West Smithfield, 18–20 Cock Lane and 1–4 Giltspur Street (WES89). Microscopy was used to identify roundworm eggs in 10.3 per cent of burials. We integrate these results with past palaeoparasitological work in the province of Britannia to explore disease, hygiene and diet. The most commonly found parasites (whipworm and roundworm) were spread by poor sanitation, but other species caught from animals were also present (fish tapeworm, beef/pork tapeworm and liver flukes). Parasite diversity was highest in urban sites. The health impacts of these infections range from asymptomatic to severe.
Religion and responsibility in international relations: Thatcher, Mahathir, and The Satanic Verses
Authors: Smith David T. 
Published: October 2024

Abstract
The crisis over Salman Rushdie’s novel The Satanic Verses exposed the contrasting ways Western and Muslim actors understand the place of religion in international order and the responsibilities of states in religious controversies. No other Muslim national leader supported Ayatollah Khomeini’s call for Rushdie’s death in 1989, but many Muslims expressed anger and disbelief that Britain and Western powers could not restrict a book that caused so much international disturbance. This paper seeks to understand this discord through the overlapping but conflicted language games of Western and Muslim national leaders. It analyses a previously unreported exchange of letters between British prime minister Margaret Thatcher and Malaysian prime minister Mahathir Mohamad, along with other recently released archival material from the diplomatic crisis. These letters reflected different unwritten rules informing the actors’ understandings and practices of international order, despite their shared acceptance of the sovereignty of national states. For Mahathir, the Western world was itself a religious identity, and its collective propagation of The Satanic Verses compounded a religious insult to the Muslim world. But Thatcher and other British actors did not see religious identities, especially their own, as basic elements of international relations, instead reasserting the secular primacy of national states.
Testing the relationship between preferences for infant-directed speech and vocabulary development: A multi-lab study
Authors: Soderstrom Melanie , Rocha-Hidalgo Joscelin , Muñoz Luis E. , Bochynska Agata , Werker Janet F. , Skarabela Barbora , Seidl Amanda , Ryjova Yana , Rennels Jennifer L. , Potter Christine E. , Paulus Markus , Ota Mitsuhiko , Olesen Nonah M. , Nave Karli M. , Mayor Julien , Martin Alia , Machon Lauren C. , Lew-Williams Casey , Ko Eon-Suk , Kim Hyunji , Kartushina Natalia , Kammermeier Marina , Jessop Andrew , Hay Jessica F. , Havron Naomi , Hannon Erin E. , Kiley Hamlin J. , Gonzalez-Gomez Nayeli , Gampe Anja , Fritzsche Tom , Frank Michael C. , Durrant Samantha , Davies Catherine , Cashon Cara , Byers-Heinlein Krista , Boyce Veronica , Black Alexis K. , Bergmann Christina , Anderson Laura , Alshakhori Mohammed K. , Al-Hoorie Ali H. , Tsui Angeline S. M. 
Published: October 2024

Abstract
From early on, infants show a preference for infant-directed speech (IDS) over adult-directed speech (ADS), and exposure to IDS has been correlated with language outcome measures such as vocabulary. The present multi-laboratory study explores this issue by investigating whether there is a link between early preference for IDS and later vocabulary size. Infants’ preference for IDS was tested as part of the ManyBabies 1 project, and follow-up CDI data were collected from a subsample of this dataset at 18 and 24 months. A total of 341 (18 months) and 327 (24 months) infants were tested across 21 laboratories. In neither preregistered analyses with North American and UK English, nor exploratory analyses with a larger sample did we find evidence for a relation between IDS preference and later vocabulary. We discuss implications of this finding in light of recent work suggesting that IDS preference measured in the laboratory has low test-retest reliability.
A Millian Case against Epistemic Arguments for Federalism
Authors: Da Silva Michael 
Published: October 2024

AbstractJohn Stuart Mill is central to parallel debates in mainstream contemporary political epistemology and philosophy of federalism concerning the epistemic dimension(s) of legitimate authority. Many scholars invoke Mill to support epistemic arguments for democratic decision-making and decentralized federalism as a means of conferring democratic legitimacy. This article argues that Millian considerations instead provide reason to reject common epistemic arguments for decentralized federalism. Combining Mill's own insights about the epistemic costs of decentralization and recent work in philosophy, politics, and economics undermines purportedly Millian arguments for federalism focused on political experimentation, diversity and participation. Contrary to many interpretations, Millian considerations weaken, rather than strengthen, arguments for federalism. Any valid justification for federalism must instead rest on non-epistemic considerations. This conclusion is notable regardless of how one interprets Mill. But it also supports Mill's stated preference for local decisions subject to central oversight.
Morphological and Structural Characterization of Shortening Landforms on Mars
Authors: McCullough Leta R. , Crane Kelsey T. , Loveless Stephan R. , Klimczak Christian 
Published: October 2024

AbstractThe lithosphere of Mars accommodates horizontal shortening through folding and faulting, producing landforms described as wrinkle ridges or lobate scarps. Despite this nomenclature, we lack a deep understanding of the drivers of morphological differences observed between landform types. This study aims to develop a quantitative model for shortening landform classification based on surface morphology, subsurface architecture, and strain accommodation, facilitating interpretations of where and how lithospheric stresses are recorded. We developed this model by mapping 100 shortening landforms in a Geographic Information System, recording 12 unique geomorphic parameters such as length and asymmetry, and estimating the strain of each landform. We conducted a Discriminant Function Analysis (DFA) using surface morphometrics. This DFA produced a predictive linear function for categorizing wrinkle ridges and lobate scarps and for quantifying which landforms were exemplars within those categories. The three most influential variables on the surface morphometry DFA were the maximum width, forelimb slope, and back limb length. We then modeled the subsurface structural geology of 50 landforms using MOVE Structural Geology Modeling Software and conducted a second DFA based on subsurface metrics. DFA was most influenced by the dip and depth of the lower ramp base. When both surface morphology and subsurface geometry are input into single DFA, wrinkle ridges and lobate scarps can be distinguished quantitatively 96% of the time. Our results also show that lobate scarps accommodate more strain and imply that studies should consider landform type when interpreting local, regional, and global geological stress histories.
Machine‐Assisted Physical Closure for Coarse Suspended Sediments in Vegetated Turbulent Channel Flows
Authors: Li Shuolin , Qu Yongquan , Zheng Tian , Gentine Pierre 
Published: October 2024

AbstractThe parameterization of suspended sediments in vegetated flows presents a significant challenge, yet it is crucial across various environmental and geophysical disciplines. This study focuses on modeling suspended sediment concentrations (SSC) in vegetated flows with a canopy density of avH ∈ [0.3, 1.0] by examining turbulent dispersive flux. While conventional studies disregard dispersive momentum flux for avH > 0.1, our findings reveal significant dispersive sediment flux for large particles with a diameter‐to‐Kolmogorov length ratio when dp/η > 0.1. Traditional Rouse alike approaches therefore must be revised to account for this effect. We introduce a hybrid methodology that combines physical modeling with machine learning to parameterize dispersive flux, guided by constraints from diffusive and settling fluxes, characterized using recent covariance and turbulent settling methods, respectively. The model predictions align well with reported SSC data, demonstrating the versatility of the model in parameterizing sediment‐vegetation interactions in turbulent flows.
Cold and hot tumors: from molecular mechanisms to targeted therapy
Authors: Wu Bo , Zhang Bo , Li Bowen , Wu Haoqi , Jiang Meixi 
Published: October 2024

AbstractImmunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which has shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment in cancer therapy, only a minority of patients exhibit a positive response to it. In patients with solid tumors, those who respond well to ICB treatment typically demonstrate an active immune profile referred to as the “hot” (immune-inflamed) phenotype. On the other hand, non-responsive patients may exhibit a distinct “cold” (immune-desert) phenotype, differing from the features of “hot” tumors. Additionally, there is a more nuanced “excluded” immune phenotype, positioned between the “cold” and “hot” categories, known as the immune “excluded” type. Effective differentiation between “cold” and “hot” tumors, and understanding tumor intrinsic factors, immune characteristics, TME, and external factors are critical for predicting tumor response and treatment results. It is widely accepted that ICB therapy exerts a more profound effect on “hot” tumors, with limited efficacy against “cold” or “altered” tumors, necessitating combinations with other therapeutic modalities to enhance immune cell infiltration into tumor tissue and convert “cold” or “altered” tumors into “hot” ones. Therefore, aligning with the traits of “cold” and “hot” tumors, this review systematically delineates the respective immune characteristics, influencing factors, and extensively discusses varied treatment approaches and drug targets based on “cold” and “hot” tumors to assess clinical efficacy.