bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frequency of takeaway food consumption and its association with major food group consumption, anthropometric measures and blood pressure during adolescence
Authors: Gopinath Bamini , Flood Victoria M. , Burlutsky George , Louie Jimmy C. Y. , Baur Louise A. , Mitchell Paul 
Published: April 2016

AbstractWe prospectively assessed the (1) frequency and socio-economic correlates of takeaway food consumption during adolescence; and (2) association between frequent takeaway food consumption with intakes of major food groups and anthropometric measures and blood pressure (BP). In total, 699 Sydney schoolchildren (380 girls and 319 boys) who had dietary data at both 12 and 17 years of age were included for analyses. Takeaway food consumption was self-reported and based on a single question. Anthropometric measures and BP were collected. The proportion of participants who ate takeaway foods once per week or more increased significantly over 5 years from the age of 12 to 17 years: 35·5–44·1 % (P<0·0001). In total, 12-year-old girls compared with boys had reduced odds of takeaway foods once per week or more at the age of 17 years (P=0·01), multivariable-adjusted OR 0·63 (95 % CI 0·44, 0·90). In total, 12-year-old children who ate takeaway foods once per week or more had significantly lower mean fruit (220·3 v. 253·0 g/d; P=0·03) and vegetable consumption (213·2 v. 247·7 g/d; P=0·004), 5 years later (at 17 years of age). Frequent takeaway food consumption at the age of 12 years was not associated with anthropometric indices and BP at the age of 17 years. Consumption of takeaway foods became more frequent during adolescence, particularly among boys, and it was associated with reduced intake of fruits and vegetables.
Sexual communication in day-flying Lepidoptera with special reference to castniids or ‘butterfly-moths’
Authors: Sarto i Monteys V. , Quero C. , Santa-Cruz M.C. , Rosell G. , Guerrero A. 
Published: April 2016

AbstractButterflies and moths are subject to different evolutionary pressures that affect several aspects of their behaviour and physiology, particularly sexual communication. Butterflies are day-flying insects (excluding hedylids) whose partner-finding strategy is mainly based on visual cues and female butterflies having apparently lost the typical sex pheromone glands. Moths, in contrast, are mostly night-flyers and use female-released long-range pheromones for partner-finding. However, some moth families are exclusively day-flyers, and therefore subject to evolutionary pressures similar to those endured by butterflies. Among them, the Castniidae, also called ‘butterfly-moths’ or ‘sun-moths’, behave like butterflies and, thus, castniid females appear to have also lost their pheromone glands, an unparallel attribute in the world of moths. In this paper, we review the sexual communication strategy in day-flying Lepidoptera, mainly butterflies (superfamily Papilionoidea), Zygaenidae and Castniidae moths, and compare their mating behaviour with that of moth families of nocturnal habits, paying particular attention to the recently discovered butterfly-like partner-finding strategy of castniids and the fascinating facts and debates that led to its discovery.
Effects of climatic factors, drought risk and irrigation requirement on maize yield in the Northeast Farming Region of China
Authors: YIN X. G. , JABLOUN M. , OLESEN J. E. , ÖZTÜRK I. , WANG M. , CHEN F. 
Published: April 2016

SUMMARYDrought risk is considered to be among the main limiting factors for maize (Zea maysL.) production in the Northeast Farming Region of China (NFR). Maize yield data from 44 stations over the period 1961–2010 were combined with data from weather stations to evaluate the effects of climatic factors, drought risk and irrigation requirement on rain-fed maize yield in specific maize growth phases. The maize growing season was divided into four growth phases comprising seeding, vegetative, flowering and maturity based on observations of phenological data from 1981 to 2010. The dual crop coefficient was used to calculate crop evapotranspiration and soil water balance during the maize growing season. The effects of mean temperature, solar radiation, effective rainfall, water deficit, drought stress days, actual crop evapotranspiration and irrigation requirement in different growth phases were included in the statistical model to predict maize yield. During the period 1961–2010, mean temperature increased significantly in all growth phases in NFR, while solar radiation decreased significantly in southern NFR in the seeding, vegetative and flowering phases. Effective rainfall increased in the seeding and vegetative phases, reducing water deficit over the period, whereas decreasing effective rainfall over time in the flowering and maturity phases enhanced water deficit. An increase in days with drought stress was concentrated in western NFR, with larger volumes of irrigation needed to compensate for increased dryness. The present results indicate that higher mean temperature in the seeding and maturity phases was beneficial for maize yield, whereas excessive rainfall would damage maize yield, in particular in the seeding and flowering phases. Drought stress in any growth stage was found to reduce maize yield and water deficit was slightly better than other indicators of drought stress for explaining yield variability. The effect of drought stress was particularly strong in the seeding and flowering phases, indicating that these periods should be given priority for irrigation. The yield-reducing effects of both drought and intense rainfall illustrate the importance of further development of irrigation and drainage systems for ensuring the stability of maize production in NFR.
FROM ANALOGUE TO DIGITAL: AN INTERVIEW WITH GOTTFRIED MICHAEL KOENIG
Authors: Iverson Jennifer 
Published: April 2016

AbstractGottfried Michael Koenig (b. 1926) is a seminal figure in the history of electronic music. He contributed important technical and musical ideas at WDR studio in Cologne from 1954 to 1964. He was then the director of the Institute of Sonology in Utrecht, Netherlands until 1986. Since 1986, Koenig has continued to compose, to develop complex computer systems, and to edit, translate, and publish his extensive corpus of theoretical writings.1 This conversation, which aims to foster further English-language scholarship on Koenig and his music,2 took place in English in May 2015 at the Institute of Sonology, now located in The Hague, Netherlands.
Buckwheat phenolic metabolites in health and disease
Authors: Kreft Marko 
Published: April 2016

AbstractBuckwheat (Fagopyrum esculentum Moench, F. tataricum Gaertner) groats and flour have been established globally as nutritional foods because of their high levels of proteins, polyphenols and minerals. In some regions, buckwheat herb is used as a functional food. In the present study, reports of in vitro studies, preclinical and clinical trials dealing with the effect of buckwheat and its metabolites were reviewed. There are numerous reports of potential health benefits of consuming buckwheat, which may be in the form of food, dietary supplements, home remedies or possibly pharmaceutical drugs; however, adverse effects, including those resulting from contamination, must be considered. There are reports of antioxidative activity of buckwheat, which contains high levels of rutin and quercetin. On the other hand, both cytotoxic and antigenotoxic effects have been shown. Reduction of hyperlipidaemia, reduction of blood pressure and improved weight regulation have been suggested. Consuming buckwheat may have a beneficial effect on diabetes, since lower postprandial blood glucose and insulin response have been reported. In addition, buckwheat metabolites, such as rutin, may have intrinsic protective effects in preserving insulin signalling. Rutin has also been suggested to have potential therapeutic applications for the treatment of Alzheimer’s disease. The literature indicates that buckwheat is safe to consume and may have various beneficial effects on human health.
Characterizing the Impact of Extreme Heat on Mortality, Karachi, Pakistan, June 2015
Authors: Ghumman Usman , Horney Jennifer 
Published: April 2016

AbstractIntroductionKarachi, Pakistan was affected by a heat wave in June 2015 during the Muslim holy month of Ramadan. Many media reports attributed the excess deaths in part to the practice of daylight fasting during Ramadan. As much of the published research reports on heat-related mortality in Europe and the United States, an exploration of the effects of extreme heat on residents of a South Asian mega-city address a gap in current disaster research.Hypothesis/ProblemThis report investigated potential risk factors for excess mortality associated with the June 2015 heat wave in Karachi, Pakistan.MethodsData were obtained through manual review of death certificates at public hospitals and private clinics in Karachi, Pakistan, conducted from July 1 through July 31, 2015 by a trained physician. Demographic data for any deaths with a primary cause of death of heat-related illness were recorded in Microsoft Excel (Microsoft Corp.; Redmond, Washington USA). EpiSheet (2012; Rothman. Modern Epidemiology. Lippincott Williams & Wilkins; Philadelphia, Pennsylvania USA) was used to calculate risk differences (RD), rate ratios (RR), and 95% confidence intervals (95% CI).ResultsOverall, residents of Karachi were approximately 17 times as likely to die of a heat-related cause of death during June 2015 (RR=17.68; 95% CI, 13.87-22.53) when compared with the reference period of June 2014. Residents with a monthly income lower than 20,000 Pakistani Rupees (US $196; RD=0.03; 95% CI, 0.01-0.05) and those with less than a fifth grade education (RD=0.03; 95% CI, 0.00-0.05) were at significantly higher risk of death during the 2015 heat wave compared to the reference period.ConclusionFasting during Ramadan was not a significant risk factor for mortality from heat-related causes during the Karachi heat wave of June 2015. A large number of excess deaths were reported across all demographic groups, which due to the burden of record keeping in an under-resourced health system during a public health emergency, are almost certainly an underestimate.GhummanU, HorneyJ. Characterizing the impact of extreme heat on mortality, Karachi, Pakistan, June 2015. Prehosp Disaster Med. 2016;31(3):263–266.
Screening of cultivated and wildHelianthusspecies reveals herbicide tolerance in wild sunflowers and allelic variation atAhasl1(acetohydroxyacid synthase 1 large subunit) locus
Authors: Jacob Jinu , Sujatha Mulpuri , Varaprasad Sivannarayana Kodeboyina 
Published: April 2016

AbstractAcetohydroxyacid synthase (AHAS) inhibiting herbicides have played a significant role in effective weed control in the cultivation of sunflower since their discovery. The development of sunflower lines and hybrids resistant to these herbicides made their post-emergence application possible. In this study, wildHelianthusspecies were screened phenotypically for imidazolinone (IMI) and sulfonylurea (SU) resistance by herbicide spray and for allelic variations atAhasl1(Ahas1 large subunit) locus using simple sequence repeat and single nucleotide polymorphism markers.Helianthus praecoxaccession 1823 plants showed promising resistance to three classes of SU-based herbicides andHelianthus nuttalliiaccession NUT05 plants remained green for a longer time after imazethapyr spray. A total of 50 accessions belonging to 21 wildHelianthusspecies of different ploidy levels were analysed for allelic variation along with some parents of commercial sunflower hybrids. None of the wild species showed the resistant allele (Ahasl1-1) similar to SCG101 (IMI-resistant line), although it is present in some of the parental lines of hybrids. However, the parental lines havingAhasl1-1-type allele failed to survive the field dose of imazethapyr spray. Inter-species and inter-accessional allelic variation could be observed among the species. PRA1823 and NUT05 showed repeat length variations atAhasl1locus. Sequencing of full lengthAhasl1gene from both these accessions did not reveal any resistance mutations in the protein sequences. The molecular basis of the phenotypes identified in this study could be explored further and utilized in breeding programmes for imparting herbicide resistance in cultivated hybrids across sunflower growing regions of the world.
Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft
Authors: Mohiuddin Muhammad M. , Singh Avneesh K. , Corcoran Philip C. , Thomas III Marvin L. , Clark Tannia , Lewis Billeta G. , Hoyt Robert F. , Eckhaus Michael , Pierson III Richard N. , Belli Aaron J. , Wolf Eckhard , Klymiuk Nikolai , Phelps Carol , Reimann Keith A. , Ayares David , Horvath Keith A. 
Published: April 2016

AbstractPreventing xenograft rejection is one of the greatest challenges of transplantation medicine. Here, we describe a reproducible, long-term survival of cardiac xenografts from alpha 1-3 galactosyltransferase gene knockout pigs, which express human complement regulatory protein CD46 and human thrombomodulin (GTKO.hCD46.hTBM), that were transplanted into baboons. Our immunomodulatory drug regimen includes induction with anti-thymocyte globulin and αCD20 antibody, followed by maintenance with mycophenolate mofetil and an intensively dosed αCD40 (2C10R4) antibody. Median (298 days) and longest (945 days) graft survival in five consecutive recipients using this regimen is significantly prolonged over our recently established survival benchmarks (180 and 500 days, respectively). Remarkably, the reduction of αCD40 antibody dose on day 100 or after 1 year resulted in recrudescence of anti-pig antibody and graft failure. In conclusion, genetic modifications (GTKO.hCD46.hTBM) combined with the treatment regimen tested here consistently prevent humoral rejection and systemic coagulation pathway dysregulation, sustaining long-term cardiac xenograft survival beyond 900 days.
ASK1 signalling regulates brown and beige adipocyte function
Authors: Hattori Kazuki , Naguro Isao , Okabe Kohki , Funatsu Takashi , Furutani Shotaro , Takeda Kohsuke , Ichijo Hidenori 
Published: April 2016

AbstractRecent studies suggest that adult humans have active brown or beige adipocytes, the activation of which might be a therapeutic strategy for the treatment of diverse metabolic diseases. Here we show that the protein kinase ASK1 regulates brown and beige adipocytes function. In brown or white adipocytes, the PKA-ASK1-p38 axis is activated in response to cAMP signalling and contributes to the cell-autonomous induction of genes, including Ucp1. Global and fat-specific ASK1 deficiency leads to impaired metabolic responses, including thermogenesis and oxygen consumption, at the cell and whole-body levels, respectively. Our data thus indicate that the ASK1 signalling axis is a regulator of brown and beige adipocyte gene expression and function.
FoxA and LIPG endothelial lipase control the uptake of extracellular lipids for breast cancer growth
Authors: Slebe Felipe , Rojo Federico , Vinaixa Maria , García-Rocha Mar , Testoni Giorgia , Guiu Marc , Planet Evarist , Samino Sara , Arenas Enrique J. , Beltran Antoni , Rovira Ana , Lluch Ana , Salvatella Xavier , Yanes Oscar , Albanell Joan , Guinovart Joan J. , Gomis Roger R. 
Published: April 2016

AbstractThe mechanisms that allow breast cancer (BCa) cells to metabolically sustain rapid growth are poorly understood. Here we report that BCa cells are dependent on a mechanism to supply precursors for intracellular lipid production derived from extracellular sources and that the endothelial lipase (LIPG) fulfils this function. LIPG expression allows the import of lipid precursors, thereby contributing to BCa proliferation. LIPG stands out as an essential component of the lipid metabolic adaptations that BCa cells, and not normal tissue, must undergo to support high proliferation rates. LIPG is ubiquitously and highly expressed under the control of FoxA1 or FoxA2 in all BCa subtypes. The downregulation of either LIPG or FoxA in transformed cells results in decreased proliferation and impaired synthesis of intracellular lipids.
A multiplexed light-matter interface for fibre-based quantum networks
Authors: Saglamyurek Erhan , Grimau Puigibert Marcelli , Zhou Qiang , Giner Lambert , Marsili Francesco , Verma Varun B. , Woo Nam Sae , Oesterling Lee , Nippa David , Oblak Daniel , Tittel Wolfgang 
Published: April 2016

AbstractProcessing and distributing quantum information using photons through fibre-optic or free-space links are essential for building future quantum networks. The scalability needed for such networks can be achieved by employing photonic quantum states that are multiplexed into time and/or frequency, and light-matter interfaces that are able to store and process such states with large time-bandwidth product and multimode capacities. Despite important progress in developing such devices, the demonstration of these capabilities using non-classical light remains challenging. Here, employing the atomic frequency comb quantum memory protocol in a cryogenically cooled erbium-doped optical fibre, we report the quantum storage of heralded single photons at a telecom-wavelength (1.53 μm) with a time-bandwidth product approaching 800. Furthermore, we demonstrate frequency-multimode storage and memory-based spectral-temporal photon manipulation. Notably, our demonstrations rely on fully integrated quantum technologies operating at telecommunication wavelengths. With improved storage efficiency, our light-matter interface may become a useful tool in future quantum networks.
Tissue-specific Differentiation Potency of Mesenchymal Stromal Cells from Perinatal Tissues
Authors: Kwon Ahlm , Kim Yonggoo , Kim Myungshin , Kim Jiyeon , Choi Hayoung , Jekarl Dong Wook , Lee Seungok , Kim Jung Min , Shin Jong-Chul , Park In Yang 
Published: April 2016

AbstractHuman perinatal tissue is an abundant source of mesenchymal stromal cells(MSCs) and lacks the ethical concerns. Perinatal MSCs can be obtained from various tissues as like amnion, chorion, and umbilical cord. Still, little is known of the distinct nature of each MSC type. In this study, we successfully isolated and cultured MSCs from amnion(AMSCs), chorion(CMSCs), and umbilical cord(UC-MSCs). Proliferation potential was different among them, that AMSCs revealed the lowest proliferation rate due to increased Annexin V and senescence-associated β-galactosidase positive cells. We demonstrated distinct characteristic gene expression according to the source of the original tissue using microarray. In particular, genes associated with apoptosis and senescence including CDKN2A were up-regulated in AMSCs. In CMSCs, genes associated with heart morphogenesis and blood circulation including HTR2B were up-regulated. Genes associated with neurological system processes including NPY were up-regulated in UC-MSCs. Quantitative RT-PCR confirmed the gene expression data. And in vitro differentiation of MSCs demonstrated that CMSCs and UC-MSCs had a more pronounced ability to differentiate into cardiomyocyte and neural cells, respectively. This study firstly demonstrated the innate tissue-specific differentiation potency of perinatal MSCs which can be helpful in choosing more adequate cell sources for better outcome in a specific disease.
Molecular surveillance of nasopharyngeal carriage of Streptococcus pneumoniae in children vaccinated with conjugated polysaccharide pneumococcal vaccines
Authors: Wyllie Anne L. , Wijmenga-Monsuur Alienke J. , van Houten Marlies A. , Bosch Astrid A. T. M. , Groot James A. , van Engelsdorp Gastelaars Jody , Bruin Jacob P. , Bogaert Debby , Rots Nynke Y. , Sanders Elisabeth A. M. , Trzciński Krzysztof 
Published: April 2016

AbstractFollowing the introduction of pneumococcal conjugate vaccines (PCVs) for infants, surveillance studies on Streptococcus pneumoniae carriage have proven valuable for monitoring vaccine effects. Here, we compared molecular versus conventional diagnostic methods in prospective cross-sectional surveillances in vaccinated infants in the Netherlands. Nasopharyngeal samples (n = 1169) from 11- and 24-month-old children, collected during autumn/winter 2010/2011 and 2012/2013, were tested by conventional culture for S. pneumoniae. DNA extracted from all culture-plate growth was tested by qPCR for pneumococcal-specific genes (lytA/piaB) and selected serotypes (including PCV13-serotypes). qPCR significantly increased the number of carriers detected compared to culture (69% vs. 57%, p < 0.0001). qPCR assays targeting vaccine-serotypes 4 and 5 proved non-specific (results excluded). For serotypes reliably targeted by qPCR, the number of serotype-carriage events detected by qPCR (n = 709) was 1.68× higher compared to culture (n = 422). There was a strong correlation (rho = 0.980; p < 0.0001) between the number of serotypes detected using qPCR and by culture. This study demonstrates the high potential of molecular methods in pneumococcal surveillances, particularly for enhanced serotype detection. We found no evidence of a hidden circulation of vaccine-targeted serotypes, despite vaccine-serotypes still significantly contributing to invasive pneumococcal disease in unvaccinated individuals, supporting the presence of a substantial S. pneumoniae reservoir outside vaccinated children.
Epigenetic regulation of NKG2D ligands is involved in exacerbated atherosclerosis development in Sirt6 heterozygous mice
Authors: Zhang Zhu-Qin , Ren Si-Chong , Tan Ying , Li Zuo-Zhi , Tang Xiaoqiang , Wang Ting-Ting , Hao De-Long , Zhao Xiang , Chen Hou-Zao , Liu De-Pei 
Published: April 2016

AbstractSirt6 is a member of the class III histone deacetylase family which is associated with aging and longevity. Sirt6 deficient mice show an aging-like phenotype, while male transgenic mice of Sirt6 show increased longevity. Sirt6 acts as a tumor suppressor and deficiency of Sirt6 leads to cardiac hypertrophy and heart failure. Whether Sirt6 is involved in atherosclerosis development, the major cause of cardiovascular diseases, is unknown. We found that the expression of Sirt6 is lower in human atherosclerotic plaques than that in controls. When Sirt6+/−ApoE−/− and ApoE−/− mice are fed with high fat diet for 16 weeks, Sirt6+/−ApoE−/− mice show increased plaque fromation and exhibit feature of plaque instability. Furthermore, Sirt6 downregulation increases expression of NKG2D ligands, which leads to increased cytokine expression. Blocking NKG2D ligand almost completely blocks this effect. Mechanistically, Sirt6 binds to promoters of NKG2D ligand genes and regulates the H3K9 and H3K56 acetylation levels.