bluuebunny/crossref_metadata_2025_split huggingface dataset:
H2A.Z promotes the transcription of MIR156A and MIR156C in Arabidopsis by facilitating the deposition of H3K4me3
Authors: Xu Mingli , Leichty Aaron R. , Hu Tieqiang , Poethig R. Scott 
Published: December 2017

ABSTRACT
Vegetative phase change in Arabidopsis thaliana is mediated by a decrease in the level of MIR156A and MIR156C, resulting in an increase in the expression of their targets, SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) genes. Changes in chromatin structure are required for the downregulation of MIR156A and MIR156C, but whether chromatin structure contributes to their initial elevated expression is unknown. We found that mutations in components of the SWR1 complex (ARP6, SEF) and in genes encoding H2A.Z (HTA9 and HTA11) reduce the expression of MIR156A and MIR156C, and accelerate vegetative phase change, indicating that H2A.Z promotes juvenile vegetative identity. However, arp6 and sef did not accelerate the temporal decline in miR156, and the downregulation of MIR156A and MIR156C was not accompanied by significant change in the level of H2A.Z at these loci. We conclude that H2A.Z contributes to the high expression of MIR156A/MIR156C early in shoot development, but does not regulate the timing of vegetative phase change. Our results also suggest that H2A.Z promotes the expression of MIR156A/MIR156C by facilitating the deposition of H3K4me3, rather than by decreasing nucleosome occupancy.
Pretreatment metabolic tumour volume and total lesion glycolysis are not independent prognosticators for locally advanced cervical cancer patients treated with chemoradiotherapy
Authors: Guler Ozan Cem , Torun Nese , Yildirim Berna Akkus , Onal Cem 
Published: January 2018

Objective:
To evaluate the prognostic significance of metabolic parameters derived from fludeoxyglucose (FDG) positron emission tomography (PET)/CT, in cervical cancer patients treated with concurrent chemoradiotherapy.

Methods:
We retrospectively reviewed medical records from 129 biopsy-proven non-metastatic cervical cancer patients treated with external radiotherapy and intracavitary brachytherapy at our department. Correlation between metabolic parameters and tumour characteristics was evaluated. Prognostic factors for survival, local control and distant metastasis were analysed.

Results:
The median follow up for all patients and surviving patients was 30.0 months (range, 3.7–94.7 months) and 50.5 months (range, 14.5–94.7 months), respectively. The 2- and 5-year overall survival (OS) and disease-free survival (DFS) rates were 68 42, 54 and 38%, respectively. The maximum standardized uptake value (SUVmax), SUVmean, metabolic tumour volume (MTV) and total lesion glycolysis were significantly higher in patients with larger tumours (&gt;4 cm) and partial regression or progressive disease after definitive treatment compared to patients with smaller tumour (≤4 cm) and post-treatment complete response. On univariate analysis, stage, lymph node metastasis, tumour size &gt;4 cm, SUVmax, MTV, SUVmean and total lesion glycolysis were prognostic factors for OS and DFS. On multivariate analysis, only larger tumour and presence of lymph node metastasis were significant prognostic factors for both OS and DFS. Additionally, extensive stage was a significant prognosticator for DFS.

Conclusion:
Although, metabolic parameters derived from FDG-PET/CT had a prognostic significance in univariate analysis, the significance was lost in multivariate analysis where tumour stage, size and lymph node status were the only independent parameters.

Advances in knowledge:
The clinical benefit of using FDG-PET/CT metabolic parameters to evaluate the high-risk patients among cervical cancer patients and to eventually change patient management still needs further clarification.
Incidence and pattern of brain lesions in paediatric septic shock patients
Authors: Sanz Debora , D’Arco Felice , Robles Carlos Andres , Brierley Joe 
Published: January 2018

Objective:
Brain injury is frequently observed during septic shock and may be primarily related to the direct effects of the septic insult on the brain or to secondary/indirect injuries (e.g. hypotension, hypoxaemia and hyperglycaemia). We sought to assess incidence and pattern of brain lesions diagnosed by neuroimaging in paediatric septic shock patients.

Methods:
Retrospective descriptive hospital-based study included paediatric patients with a single episode of septic shock admitted to our tertiary paediatric intensive care unit from January 2010 to December 2013.

Results:
49 of 193 septic shock patients had a neuroimaging examination [CT only 22 (45%), MRI only 14 (29%) and both 13 (27%)]. Neuroimaging was normal in 16 patients (33%) and showed acute lesions in 20 patients (40%). The most frequent findings were: cerebral infarcts/hypoxic ischaemic injury in 8 (16%) and cerebritis in 7 (14%). The incidence of acute brain lesion in our septic shock cohort was 10% (20 of 193).

Conclusion:
The diagnosis of brain dysfunction in septic shock patients relies essentially on neurological examination and neurological tests, such as electroencephalography and neuroimaging. Neuroimaging can reveal acute intracerebral structural lesions and their reversibility, helping with management and prognosis.

Advances in knowledge:
Ischaemic lesions and cerebritis are the most common brain anomalies complicating paediatric septic shock.
Autocontenção no Judiciário Brasileiro: uma análise das relações estratégicas entre os Poderes constituídos do Estado
Authors: Pontes Juliana De Brito , Gomes Neto José Mário Wanderley , Teixeira João Paulo Fernandes de Souza Allain 
Published: January 2018

A arguição de descumprimento de preceito fundamental (ADPF) é um instrumento processual-constitucional tipicamente brasileiro, capaz de impedir atos de ameaça ou violação a preceito fundamental, decorrentes do Poder Público. O contexto marcante da judicialização da política na jurisdição constitucional brasileira evidencia o reduzido número de arguições de descumprimento julgadas. Pretende-se traçar o perfil empírico do funcionamento do controle de constitucionalidade por meio das ADPFs, bem como analisar a ocorrência da autocontenção judicial e o comportamento dos magistrados ao proferirem decisões referentes às ADPFs. Para tanto, houve avaliação quantitativa do total das arguições catalogadas e análise qualitativa das arguições julgadas e não julgadas a partir do estudo de casos abrangendo as ADPFs propostas, sendo distribuídas conforme variáveis e analisada a distribuição de frequências por meio da elaboração de gráficos. Buscou-se compreender a seletividade no julgamento das ADPFs realizada pelo Supremo Tribunal Federal (STF), especificando os elementos que motivaram o efetivo processo decisório e os fatores que permitem a prática de autocontenção pela Suprema Corte brasileira. Verificou-se o conflito entre os Poderes Executivo e Judiciário: grande parte das arguições propostas tem como maior violador o próprio Poder Judiciário, porém, quando este profere decisões de mérito nas ADPFs, julga em maioria as ações que tiveram como violador o Poder Executivo, impedindo que as ações contra o Judiciário tenham continuidade, e este seja reconhecido como maior violador dos direitos e garantias fundamentais. Espera-se, com a realização desta pesquisa, contribuir para a compreensão das relações estratégicas entre os Poderes constituídos do Estado.
Oh What a Beautiful Morning! Diurnal Influences on Executives and Analysts: Evidence from Conference Calls
Authors: Chen Jing , Demers Elizabeth , Lev Baruch 
Published: January 2018

This study provides novel evidence that expert economic agents’ work-related activities are systematically influenced by the time of day. We use archival data derived from time-stamped quarterly earnings conference calls together with linguistic algorithms to measure and track the moods of executives and analysts at different times of the day. The evidence indicates that the tone of conference call discussions deteriorates markedly over the course of the trading day, with both analysts’ and executives’ moods becoming more negative as the day wears on. Capital market pricing tests reveal that the time-of-day-induced negative tone leads to temporary stock mispricings. Our findings are relevant because the diurnal variations in behavior documented in the context of quarterly earnings calls are likely to extend across other important corporate communication, decision making, and performance situations, leading to potentially significant economic consequences. This paper was accepted by Shiva Rajgopal, accounting.
Hepatoprotective properties for Salvia cryptantha extract on carbon tetrachloride-induced liver injury
Authors: Yalcin Alper , Yumrutas Onder , Kuloglu Tuncay , Elibol Ebru , Parlar Ali , Yilmaz ć°smet , Pehlivan Mustafa , Dogukan Mevlut , Uckardes Fatih , Aydin Hasan , Turk Ahmet , Uludag Oznur , Sahin ć°brahim , Ugur Kader , Aydin Suleyman 
Published: January 2018

The present study was designed to determine the possible hepatoprotective effects of Salvia cryptantha (black weed) plant extract against carbon tetrachloride (CCl4)-induced hepatic injury in rats. Animals were grouped as follows: control group (Group I), CCl4 group (Group II), olive oil group (Group III), CCl4 + S. cryphantha 200 mg/kg group (Group IV), and CCl4 + S. cryptantha 400mg/kg group (Group V). Rats were injected intraperitoneally with CCl4 diluted in olive oil (50% v/v) at a dose of 1ml/kg body weight. Bax and Caspase3 were determined by immunohistochemical staining, while apoptotic index was evaluated using TUNEL assay. Total mRNA was isolated from liver tissues, and the levels of BCL2, Caspase3, SOD, CAT, and glutathione peroxidase (GPx) were determined by using PCR, while MDA level were determined using a colorimetric assay. The antioxidant and anti-apoptotic gene transcripts were decreased in all of the control and treatment groups, while Caspase3 levels were not statistically different. The S. cryptantha plant extract treatment was also found to improve SOD, GPx, and catalase levels, while reducing the serum levels of MDA. The extract of S. cryptantha supplementation had a protective effect against CCl4-induced liver damage. S. cryptantha extract as a supplement may be useful as a hepato-protective agent to combat the toxic effects caused by CCl4 and other chemicals.
Urinary tract infection in Children Hospitalized at Constanta Clinical Infectious Diseases Hospital
Authors: Pînzaru Anca Daniela , Mihai Raluca , Burcea Octavia , Cambrea Simona Claudia 
Published: December 2017

Abstract
Introduction: In pediatrics, the urinary tract infection is one of the most frequent bacterial infection, representing an important health problem due to its high incidence, wide etiology, asymptomatic evolution, and multiple and sever complications, relapses and sequelae.” Material and Method: We evaluated 45 children, aged between 6 months and 16 years, diagnosed and treated for urinary tract infection at the Clinical Infectious Diseases Hospital, of Constanta County, in a period of 3 years and 6 months. Results: During studied period, between January 2014 and June 2017 from a total of 9343 patients admitted to the Constanta Clinical Infectious Diseases Hospital, we selected 45 children (4.81‰) diagnosed with urinary tract infection. The average age of children with urinary tract infections was 5 years and 5 months. The gender distribution revealed a 2:1 balance in girl’s favor. The most affected group of age was 1-3 years. Fever was the dominating symptom. Urine cultures were positive for 37 cases, meanwhile for eight cases had been negative. The predominant germs are E. coli for female and for male Proteus. We noticed that for E. coli the highest sensitivity is preserved to Ertapenem -15 cases, followed by Ceftriaxone and Ciprofloxacin -10 cases each, and Gentamycin -9 cases. Conclusions: Pediatric urinary tract infection should be considered in every patient under 3 years with unexplained fever.
Basal cell adenocarcinoma of the tongue- A rarity Case report
Authors: Madiyal Ananya , Subhas Babu G. , Ajila Vidya , Hegde Shruthi 
Published: December 2017

Abstract
Basal cell adenocarcinoma is an unusual basaloid tumour that usually affects the parotid and very rarely involves the submandibular or minor salivary glands. It constitutes 1.6% of all salivary gland tumours and occurs as an asymptomatic freely mobile mass with occasional lymph node metastasis. Differentiation from benign salivary gland tumours like basal cell adenoma is accomplished by determining the depth of tumour invasion and patterns of growth or infiltration. Although it is categorised as a low-grade malignancy, it has a high propensity for recurrence. Surgical excision with a wide margin is the preferred course of treatment with radiotherapy being reserved only for tumours of the minor salivary glands with a diffuse pattern of infiltration. We present here a case of basal cell adenocarcinoma with a rare presentation in the minor salivary glands of the tongue which arose from a previously treated basal cell adenoma in the same site.
Computer-aided drug design of capuramycin analogues as anti-tuberculosis antibiotics by 3D-QSAR and molecular docking
Authors: Jin Yuanyuan , Fan Shuai , Lv Guangxin , Meng Haoyi , Sun Zhengyang , Jiang Wei , Van Lanen Steven G. , Yang Zhaoyong 
Published: December 2017

AbstractCapuramycin and a few semisynthetic derivatives have shown potential as anti-tuberculosis antibiotics.To understand their mechanism of action and structureactivity relationships a 3D-QSAR and molecular docking studies were performed. A set of 52 capuramycin derivatives for the training set and 13 for the validation set was used. A highly predictive MFA model was obtained with crossvalidated q2of 0.398, and non-cross validated partial least-squares (PLS) analysis showed a conventional r2of 0.976 and r2predof 0.839. The model has an excellent predictive ability. Combining the 3D-QSAR and molecular docking studies, a number of new capuramycin analogs with predicted improved activities were designed. Biological activity tests of one analog showed useful antibiotic activity againstMycobacterium smegmatisMC2 155 andMycobacterium tuberculosisH37Rv. Computer-aided molecular docking and 3D-QSAR can improve the design of new capuramycin antimycobacterial antibiotics.
Giant Frontoethmoidal osteoma with orbital involvementa rare case report with review of literature
Authors: Gupta Pankaj , Sharma Arvind , Singh Jitendra , Ojha Tarun 
Published: December 2017

Abstract
Osteomas are benign tumours that involve paranasal sinuses more than other parts of body. Frontal sinus is most common while sphenoid is least one. They are usually asymptomatic and diagnosed incidentally on imaging for other reasons. Giant variety of frontoethmoid osteoma is very rare and only few cases are described in literature. Orbital involvement in giant frontoethmoid osteoma is even rarer. Due to threat to vision, this variety is an indication for surgical intervention followed by reconstruction of defect. As these tumours are very large, endoscopic approaches are less indicated and there is no clear consensus which open surgical approach is better. We are reporting such a rare case of giant frontoethmoid osteoma causing proptosis and restriction of eye movement that was treated with open surgical approach.
Insights from the Think&EatGreen@School Project: How a community-based action research project contributed to healthy and sustainable school food systems in Vancouver
Authors: Rojas Alejandro , Black Jennifer , Orrego Elena , Chapman Gwen , Valley Will 
Published: January 2018

From 2010 to 2016 the Think&EatGreen@School project worked to create healthy and sustainable school food systems in the Vancouver School Board. Using models of Community-Engaged Scholarship and Community-Based Action Research, we implemented diverse programmatic and monitoring activities to provide students and teachers with hands-on food cycle education, in order to influence policy, and to encourage university students to engage actively with the food system. Our focus was on transformation of local school food systems as a context-specific means to address serious global issues related to food security, health and environmental sustainability. This paper provides a synthesis of the project including the context that led to its inception, its overarching goals, methodological framework and areas of impact. Key learnings from this project highlight the need for continued work to integrate research, teaching and action on global food security, environmental and public health challenges and to build connections to create healthy, sustainable school food systems.
Ritkábban előforduló, alsó légúti fertőzést okozó Gram-negatív nem fermentáló pálcák
Authors: Juhász Emese , Iván Miklós , Pongrácz Júlia , Kristóf Katalin 
Published: January 2018

Abstract: Introduction: Glucose non-fermenting Gram-negative bacteria are ubiquitous environmental organisms. Most of them are identified as opportunistic, nosocomial pathogens in patients. Uncommon species are identified accurately, mainly due to the introduction of matrix-assisted laser desorption-ionization time of flight mass spectrometry (MALDI-TOF MS) in clinical microbiology practice. Most of these uncommon non-fermenting rods are isolated from lower respiratory tract samples. Their significance in lower respiratory tract infections, such as rules of their testing are not clarified yet. Aim: The aim of this study was to review the clinical microbiological features of these bacteria, especially their roles in lower respiratory tract infections and antibiotic treatment options. Method: Lower respiratory tract samples of 3589 patients collected in a four-year period (2013–2016) were analyzed retrospectively at Semmelweis University (Budapest, Hungary). Identification of bacteria was performed by MALDI-TOF MS, the antibiotic susceptibility was tested by disk diffusion method. Results: Stenotrophomonas maltophilia was revealed to be the second, whereas Acinetobacter baumannii the third most common non-fermenting rod in lower respiratory tract samples, behind the most common Pseudomonas aeruginosa. The total number of uncommon non-fermenting Gram-negative isolates was 742. Twenty-three percent of isolates were Achromobacter xylosoxidans. Beside Chryseobacterium, Rhizobium, Delftia, Elizabethkingia, Ralstonia and Ochrobactrum species, and few other uncommon species were identified among our isolates. The accurate identification of this species is obligatory, while most of them show intrinsic resistance to aminoglycosides. Resistance to ceftazidime, cefepime, piperacillin-tazobactam and carbapenems was frequently observed also. Conclusions: Ciprofloxacin, levofloxacin and trimethoprim-sulfamethoxazole were found to be the most effective antibiotic agents. Orv Hetil. 2018; 159(1): 23–30.
Patentes e o direito à saúde: análise sobre as discussões de propriedade intelectual na Organização Mundial da Saúde, entre 2006 e 2016.
Authors: Oliveira Lucas Felipe Carvalho , Santos Alethele de Oliveira 
Published: December 2017

RESUMO: Introdução – A propriedade intelectual instituída pelo Acordo TRIPS nos países signatários da Organização Mundial do Comércio apresenta-se como um grande desafio aos países em desenvolvimento em relação à saúde pública, principalmente. De forma destacada a Organização Mundial da Saúde (OMS) iniciou trabalhos para discutir os impactos dos direitos de propriedade intelectual e a saúde pública. Objetivo – Analisar as discussões realizadas na OMS sobre propriedade intelectual e saúde pública, no período entre 2006 e 2016. Resultados – Houve destaque às funções sociais da propriedade intelectual, contudo, observado que países em desenvolvimento e menos desenvolvidos não são capazes de se beneficiar de uma maior proteção à propriedade intelectual, pelo que devem utilizar-se das flexibilidades presentes nas normas regulatórias, como o Acordo TRIPS e reafirmadas na Declaração de Doha. Considerações Finais – Observa-se que os debates sobre a propriedade intelectual, em especial acerca produtos farmacêuticos, vem cercada de controvérsias relacionadas ao acesso das populações aos medicamentos essenciais, à promoção da inovação e transferência de tecnologias dos países desenvolvidos aos países em desenvolvimento , Importa assinalar que no contexto brasileiro o reconhecimento de propriedade intelectual promoveu um aumento de custo dos produtos farmacêuticos, em virtude do monopólio, e torna-se um dos elementos de barreira ao acesso e à universalização do direito à saúde.
El concejo de Navia a través del «Censo de Godoy» (ISBN: 978-84-17140-29-8)
Authors: Sánchez Pascual Pablo 
Published: January 2018

RESUMENEl presente trabajo pretende contribuir a un mayor conocimiento del llamado Censo de Godoy, uno de los recuentos de población de la etapa pre-estadística más importantes y raros. Por ello, la conservación del expediente y de los cuestionarios originales correspondientes tanto al antiguo concejo de Navia (Asturias) como a sus parroquias otorga a esta documentación un especial valor, cuyo contenido nos permite analizar la estructura demográfica y económico-profesional de este concejo en 1797. Con una población que tiende a estancarse y una economía con unos valores más bien mediocres en manufacturas y servicios, Navia será un ejemplo de la situación de atraso que vive Asturias pues, a pesar de su localización en la fachada marítima del Principado —en general más desarrollada que su interior— y al igual que sucederá en otras partes de España, a finales del Antiguo Régimen se agudiza una crisis afectada por la presión fiscal y el clima bélico del reinado de Carlos IV.PALABRAS CLAVENavia; Asturias; Censo de Godoy; población; demografía; economía. TITLEThe council of Navia in the «Godoy’s census»ABSTRACTThis research aims to contribute to a better understanding of the so-called Godoy’s Census, one of the most important and rare pre-statistical population counts. For this reason, the preservation of the file and the original questionnaires corresponding to both the former council of Navia (Asturias) and its parishes give this documentation a special value, whose content allows us to analyze the demographic and economic-professional structure of the council in 1797. With a population that tends to stagnate and an economy with rather mediocre values in manufactures and services, Navia will be an example of the backward situation that lives Asturias because, despite its location in the maritime front of the Principality —generally more developed than its interior— and like what will happen in other parts of Spain, at the end of the Old Regime a crisis affected by the fiscal pressure and the warlike atmosphere of the reign of Carlos IV intensifies.KEY WORDSNavia; Asturias; Census of Godoy; population; Demography; Economy.
Religiosidad y comportamientos religiosos en la España Moderna
Authors: López Roberto J. 
Published: January 2018

RESUMENLos estudios sobre la religiosidad popular en la España Moderna se han desarrollado ampliamente en las últimas décadas. En este artículo se repasan algunas de las conclusiones y estado actual de algunos temas de investigación, y se subraya la necesidad de investigaciones más sistemáticas que permitan tener visiones de conjunto más allá de los marcos locales, y que especialmente atiendan a los efectos reales de las críticas ilustradas sobre las manifestaciones religiosas en el siglo XVIII.PALABRAS CLAVEReligiosidad, santuarios, hagiografía, reformismo ilustrado. TITLEReligiosity and religious behavior in the 18th century in SpainABSTRACTStudies on religión in the 18th century in Spain have been widely developed in recent decades. In this paper some of the findings and current status of some reserch topics are reviewed, and underlines the need for more systematic research that allow to have visions of the whole beyond the local frameworks, and that especially address the real effects of Enligthened critiques of the religious manifestations of the century.KEY WORDSReligiosity, shrines, hagiography, Enligthened reforms