bluuebunny/crossref_metadata_2025_split huggingface dataset:
Introduction of management protocol for early‐onset severe pre‐eclampsia
Authors: Sakae Chieko , Sato Yukiyasu , Kanbayashi Shota , Taga Atsuko , Emoto Ikuko , Maruyama Shunsuke , Mise Hiroko , Kim Tomoko 
Published: February 2017

AbstractAimThis quality Improvement study evaluated the applicability of our protocol for early‐onset severe pre‐eclampsia, prepared in April 2013.MethodsWe collected data from all women with early‐onset severe pre‐eclampsia treated at our hospital between March 2008 and August 2015. Neonatal and maternal outcomes were compared between protocol‐based (n = 17) and non‐protocol‐based management groups (n = 28).ResultsThe latency period was significantly longer in the protocol‐based than in the non‐protocol‐based group (21.9 ± 3.7 vs 11.0 ± 2.9 days). Gestational age at delivery was significantly more advanced in the protocol‐based than in the non‐protocol‐based group (31.4 ± 0.6 vs 29.8 ± 0.4 weeks). Serious neonatal complications were significantly less prevalent in the protocol‐based than in the non‐protocol‐based group (26% vs 79%). Among the protocol components, magnesium sulfate use was the only independent factor contributing to the absence of serious neonatal complications. The percentages of women exhibiting persistent proteinuria or hypertension at one, two and three months post‐partum were similar between the groups.ConclusionsStrict adherence to our protocol improved neonatal outcomes without affecting maternal prognosis. Routine use of magnesium sulfate could be the most important component of the protocol.
Mapping Religious Change in Latin America
Authors: Somma Nicolás M. , Bargsted Matías A. , Valenzuela Eduardo 
Published: February 2017

AbstractUsing Latinobarometer survey data, we study the evolution of religious identities among the adult populations of 17 Latin American countries between 1996 and 2013. We find several interesting patterns. First, the current religious landscape is highly dynamic and is becoming increasingly pluralist among a majority of countries. Changes derive not only from the growth of Evangelicals, as commonly assumed, but also from the sharp rise in irreligious individuals. Second, religious change cannot be convincingly explained by important theories such as secularization, religious economies, and anomie. However, the predictions derived from anomie theory seem more useful for understanding Evangelical growth. Finally, our cohort analysis indicates that aggregate religious change largely results from individual-level change across time—religious conversion and apostasy—rather than from generational replacement. Still, there are interesting variations across countries in that respect.
Invasive infections due to Saprochaete and Geotrichum species: Report of 23 cases from the FungiScope Registry
Authors: Durán Graeff Luisa , Seidel Danila , Vehreschild Maria J. G. T. , Hamprecht Axel , Kindo Anupma , Racil Zdenek , Demeter Judit , De Hoog Sybren , Aurbach Ute , Ziegler Maren , Wisplinghoff Hilmar , Cornely Oliver A. ,   FungiScope Group
Published: February 2017

SummarySaprochaete and Geotrichum spp. are rare emerging fungi causing invasive fungal diseases in immunosuppressed patients and scarce evidence is available for treatment decisions. Among 505 cases of rare IFD from the FungiScope™ registry, we identified 23 cases of invasive infections caused by these fungi reported from 10 countries over a 12‐year period. All cases were adults and previous chemotherapy with associated neutropenia was the most common co‐morbidity. Fungaemia was confirmed in 14 (61%) cases and deep organ involvement included lungs, liver, spleen, central nervous system and kidneys. Fungi were S. capitata (n=14), S. clavata (n=5), G. candidum (n=2) and Geotrichum spp. (n=2). Susceptibility was tested in 16 (70%) isolates. All S. capitata and S. clavata isolates with the exception of one S. capitata (MIC 4 mg/L) isolate had MICs>32 mg/L for caspofungin. For micafungin and anidulafungin, MICs varied between 0.25 and >32 mg/L. One case was diagnosed postmortem, 22 patients received targeted treatment, with voriconazole as the most frequent first line drug. Overall mortality was 65% (n=15). Initial echinocandin treatment was associated with worse outcome at day 30 when compared to treatment with other antifungals (amphotericin B ± flucytosine, voriconazole, fluconazole and itraconazole) (P=.036). Echinocandins are not an option for these infections.
Surgical treatment of painful florid osseous dysplasia of the mandible: a case report
Authors: Ihbe J. , Müller S. , Smolka W. 
Published: February 2017

AbstractA case is presented of a patient with painful bilateral mandibular florid osseous dysplasia without infection. The patient was edentulous. Surgical removal of the lesion led to total pain relief. To avoid long‐term drug abuse, surgical treatment might be an option to treat painful florid osseous dysplasia in selected cases especially in edentulous areas.
Practical approaches and costs for provisioning safe transfusions during anti‐CD38 therapy
Authors: Anani Waseem Q. , Marchan Marisela G. , Bensing Kathleen M. , Schanen Michael , Piefer Cindy , Gottschall Jerome L. , Denomme Gregory A. 
Published: February 2017

BACKGROUNDAnti‐CD38 therapy causes interference with both the direct and the indirect antiglobulin tests. We describe the experience from an Immunohematology Reference Laboratory and model cost options for providing safe transfusions.STUDY DESIGN AND METHODSPhenotyping, genotyping, and antibody identification orders were retrospectively reviewed in the setting of anti‐CD38 therapy. The data were used to model the added cost of transfusion support. Four approaches were evaluated: 1) thiol‐treated reagent red blood cells (RRCs) in antibody investigations with K– red blood cell (RBC) transfusions, 2) patient phenotyping or 3) genotyping with antigen‐matched RBC transfusions, and 4) a combination of interval thiol‐treated RRC antibody investigations with genotype antigen–matched RBC transfusions.RESULTSSixty‐two patients were identified as receiving anti‐CD38 therapy. Thiol‐treated RRC antibody investigations (28/62 patients) were favored over genotyping (23/62) and combination testing (11/62). Patient phenotyping failed to detect useful antigen information on eight patients: seven Fyb silencing mutations and one partial e. A thiol‐treated RRC antibody investigation was the least expensive testing method for the first transfusion, but four‐ and five‐antigen‐matched RBC transfusions were equal in cost within five and 21 transfusion events, respectively.CONCLUSIONGenotyping provided a more accurate antigen status than phenotyping patient RBCs. Patients requiring long‐term transfusion support benefit from antigen matching when matching less than four antigens. Ultimately, the decision to genotype or use thiol‐treated RRC antibody investigations will vary for each hospital blood bank.
Individualized mini‐hemilaminectomy‐corpectomy (iMHC) for treatment of thoracolumbar intervertebral disc herniation in large breed dogs
Authors: Medl Susanne C. , Reese Sven , Medl Nikola S. 
Published: February 2017

AbstractObjectiveTo assess the short‐term, mid‐term, and long‐term results after an individualized mini‐hemilaminectomy‐corpectomy (iMHC) procedure for treatment of acute and chronic thoracolumbar intervertebral disc disease in non‐chondrodystrophic dogs.Study DesignProspective study.AnimalsClient‐owned non‐chondrodystrophic large breed dogs (n = 57).MethodsThe iMHC procedure, combining mini‐hemilaminectomy (MH) and partial lateral corpectomy, was performed on non‐chondrodystrophic dogs with thoracolumbar disc disease. Neurological status was evaluated before surgery, for short‐term outcome on days 1 and 7 after surgery, for mid‐term outcome at 6 months after surgery, and for long‐term outcome at the conclusion of the study. Prognostic factors were statistically evaluated.P < .05 was considered significant.ResultsiMHC was performed on 57 dogs, with minimal intraoperative and postoperative complications. Short‐term neurological improvement was observed in 85.7% of dogs. Median hospitalization time after surgery was 2 days (range 0‐14) and was significantly shorter for dogs with a chronic history of clinical signs (1 day, range 0‐5) compared to acute onset (3 days, range 0‐14) and for those that were ambulatory at initial presentation (1 day, range 0‐5) compared to those that were not (3 days, range 0‐14). Long‐term evaluation included 53 surgeries with a mean follow‐up time of 29.4 months. Outcome was excellent in 19 dogs and good in 29 dogs (90.6% success rate). Excellent mid‐term and long‐term results were significantly more common in the dogs with only 1 affected disc space.ConclusionThe iMHC procedure resulted in a short hospitalization time, minimal postoperative deterioration, and a high success rate.
A Simple and Reliable Strategy for BK Virus Subtyping and Subgrouping
Authors: Morel Virginie , Martin Elodie , François Catherine , Helle François , Faucher Justine , Mourez Thomas , Choukroun Gabriel , Duverlie Gilles , Castelain Sandrine , Brochot Etienne 
Published: February 2017

ABSTRACT
BK virus (BKV)-associated diseases in transplant recipients are an emerging issue. However, identification of the various BK virus subtypes/subgroups is a long and delicate process on the basis of currently available data. Therefore, we wanted to define a simple and effective one-step strategy for characterizing all BK virus strains from the VP1 gene sequence. Based on the analysis of 199 available complete DNA VP1 sequences, phylogenetic trees, alignments, and isolated polymorphisms were used to define an effective strategy for distinguishing the 12 different BK virus subtypes/subgroups. Based on the 12 subtypes identified from the 199 complete BKV VP1 sequences (1,089 bp), 60 mutations that can be used to differentiate these various subtypes/subgroups were identified. Some genomic areas were more variable and comprised mutational hot spots. From a subregion of only 100 bp in the VP1 region (1977 through 2076), we therefore constructed an algorithm that enabled rapid determination of all BKV subtypes/subgroups with 99% agreement (197/199) relative to the complete VP1 sequence. We called this domain of the BK viral genome the BK typing and grouping region (BKTGR). Finally, we validated our viral subtype identification process in a population of 100 transplant recipients with 100% efficiency. The new simpler method of BKV subtyping/subgrouping reported here constitutes a useful tool for future studies that will help us to more clearly understand the impact of BKV subtypes/subgroups on diagnosis, infection, and BK virus-associated diseases.
Reduced Potency and Incomplete Neutralization of Broadly Neutralizing Antibodies against Cell-to-Cell Transmission of HIV-1 with Transmitted Founder Envs
Authors: Li Hongru , Zony Chati , Chen Ping , Chen Benjamin K. 
Published: February 2017

ABSTRACTBroadly neutralizing antibodies (bNAbs) have been isolated from HIV-1 patients and can potently block infection of a wide spectrum of HIV-1 subtypes. These antibodies define common epitopes shared by many viral isolates. While bNAbs potently antagonize infection with cell-free virus, inhibition of HIV-1 transmission from infected to uninfected CD4+T cells through virological synapses (VS) has been found to require greater amounts of antibody. In this study, we examined two well-studied molecular clones and two transmitted/founder (T/F) clones for their sensitivities to a panel of bNAbs in cell-free and cell-to-cell infection assays. We observed resistance of cell-to-cell transmission to antibody neutralization that was reflected not only by reductions of antibody potency but also by decreases in maximum neutralization capacity relative to the levels seen with cell-free infections. BNAbs targeting different epitopes exhibited incomplete neutralization against cell-associated virus with T/F Envs, which was not observed with the cell-free form of the same virus. We further identified the membrane-proximal internal tyrosine-based sorting motif as a determinant that can affect the incomplete neutralization of these T/F clones in cell-to-cell infection. These findings indicate that the signal that affects surface expression and/or internalization of Env from the plasma membrane can modulate the presentation of neutralizing epitopes on infected cells. These results highlight that a fraction of virus can escape from high concentrations of antibody through cell-to-cell infection while remaining sensitive to neutralization in cell-free infection. The ability to fully inhibit cell-to-cell transmission may represent an important consideration in the development of antibodies for treatment or prophylaxis.IMPORTANCEIn recent years, isolation of new-generation HIV-1 bNAbs has invigorated HIV vaccine research. These bNAbs display remarkable potency and breadth of coverage against cell-free virus; however, they exhibit a diminished ability to block HIV-1 cell-to-cell transmission. The mechanism(s) by which HIV-1 resists neutralization when transmitting through VS remains uncertain. We examined a panel of bNAbs for their ability to neutralize HIV-1 T/F viruses in cell-to-cell infection assays. We found that some antibodies exhibit not only reduced potency but also decreased maximum neutralization capacity orin vitroefficacy against cell-to-cell infection of HIV-1 with T/F Envs compared to cell-free infection of the same virus. We further identified the membrane-proximal internal tyrosine-based sorting motif YXXL as a determinant that can affect the incomplete neutralization phenotype of these T/F clones. When the maximum neutralization capacity falls short of 100%, this can have a major impact on the ability of antibodies to halt viral replication.
Predicting the Grade of Dysplasia of Pancreatic Cystic Neoplasms Using Cyst Fluid DNA Methylation Markers
Authors: Hata Tatsuo , Dal Molin Marco , Hong Seung-Mo , Tamura Koji , Suenaga Masaya , Yu Jun , Sedogawa Hiraku , Weiss Matthew J. , Wolfgang Christopher L. , Lennon Anne Marie , Hruban Ralph H. , Goggins Michael G. 
Published: February 2017

Abstract
Purpose: Pancreatic cysts are common and pose diagnostic and management challenges. Pancreatic cyst fluid markers have the potential to aid in the management of cysts with concerning imaging findings. Our aim was to evaluate cyst fluid methylated DNA markers for their accuracy for predicting the histologic grade of neoplastic pancreatic cysts.
Experimental Design: Pancreatic cyst fluid samples from 183 patients (29 discovery and 154 validation) aspirated after surgical resection were analyzed for methylated DNA at selected genes (SOX17, BNIP3, FOXE1, PTCHD2, SLIT2, EYA4, and SFRP1) using methylation-specific droplet-digital PCR (dd-QMSP). Methylated DNA levels were evaluated for their accuracy at predicting the grade of dysplasia of the pancreatic cyst.
Results: All six markers evaluated in the validation set could accurately distinguish high-risk cystic neoplasms (with high-grade dysplasia and/or associated invasive cancer) from low-risk cysts (lower grades of dysplasia) with accuracies from 79.8% to 83.6%. Methylated SOX17 had the highest overall accuracy as a single marker (sensitivity, 78.4%; specificity, 85.6%; accuracy 83.6%, cutoff; 25 methylated DNA molecules/μL cyst fluid). The best four-gene combination had 84.3% sensitivity, 89.4% specificity, and 88.0% accuracy at distinguishing cysts with high-grade dysplasia and/or invasive cancer from those without. All six markers were independent predictors of having invasive cancer/high-grade dysplasia after adjusting for clinical/imaging factors known to be associated with grade of dysplasia. The combination of methylated SOX17 with cytology better predicted neoplastic grade than cytology alone.
Conclusions: A panel of methylated gene markers quantified by dd-QMSP can be used to predict the grade of dysplasia of pancreatic cysts. Clin Cancer Res; 23(14); 3935–44. ©2017 AACR.
Cardiovascular Health and Healthcare Utilization and Expenditures Among Medicare Beneficiaries: The REasons for Geographic And Racial Differences in Stroke (REGARDS) Study
Authors: Aaron Kristal J. , Colantonio Lisandro D. , Deng Luqin , Judd Suzanne E. , Locher Julie L. , Safford Monika M. , Cushman Mary , Kilgore Meredith L. , Becker David J. , Muntner Paul 
Published: February 2017

Background
Better cardiovascular health is associated with lower cardiovascular disease risk.

Methods and Results

We determined the association between cardiovascular health and healthcare utilization and expenditures in the
RE
asons for Geographic And Racial Differences in Stroke (REGARDS) study. We included 6262 participants ≥65 years with Medicare fee‐for‐service coverage for the year after their baseline study visit in 2003‐2007. Cardiovascular health at baseline was assessed using the American Heart Association's Life's Simple 7 (
LS
7) metric, which includes 7 factors: cigarette smoking, physical activity, diet, body mass index, blood pressure, cholesterol, and glucose. Healthcare utilization and expenditures were ascertained using Medicare claims in the year following baseline. Overall, 17.2%, 31.1%, 29.0%, 16.4% and 6.4% of participants had 0 to 1, 2, 3, 4, and 5 to 7 ideal
LS
7 factors, respectively. The multivariable‐adjusted relative risk (95% confidence interval [
CI
]) for having any inpatient and outpatient encounters comparing participants with 5 to 7 versus 0 to 1 ideal
LS
7 factors were 0.55 (0.39, 0.76) and 1.00 (0.98, 1.02), respectively. Among participants with 0 to 1 and 5 to 7 ideal
LS
7 factors, mean inpatient expenditures were $3995 and $1250, respectively, mean outpatient expenditures were $5166 and $2853, respectively, and mean total expenditures were $9147 and $4111, respectively. After multivariable adjustment, the mean (95%
CI
) cost difference comparing participants with 5 to 7 versus 0 to 1 ideal
LS
7 factors was −$2551 (−$3667, −$1435) for inpatient, −$2410 (−$3089, −$1731) for outpatient, and −$5016 (−$6577, −$3454) for total expenditures.

Conclusions
Better cardiovascular health is associated with lower risk for inpatient encounters and lower inpatient and outpatient healthcare expenditures.
Fibular strut graft for nonunited femoral neck fractures in children
Authors: Elgeidi A. , El-Negery A. 
Published: February 2017

Purpose To evaluate the clinical and radiological outcomes of using fibular strut grafts as a fixation device for non-united femoral neck fractures in children with or without subtrochanteric valgus osteotomy. Methods A total of 12 children with non-united femoral neck fractures (nine males and three females) with an average age of 8.2 years (5 to 12) were managed, and functional results evaluated, between July 2013 and July 2015. The mechanisms of injury were fall from a height in ten patients and road traffic accident in two cases. Nine cases of femoral neck nonunion followed failed internal fixation and three cases were neglected fractures. Six cases were treated by fibular strut graft and subtrochanteric valgus osteotomy with contoured plate and six cases were treated by fibular strut graft and hip spica. Results The mean follow-up period was 20.4 months (12 to 36). Union was achieved in all 12 cases by a mean of 3.5 months (2.5 to 6). All patients were satisfied at five months. For final analysis of clinical and radiographic results, the Ratliff's classification was used. We classed 11 cases as good results and one case as fair. Conclusions Fibular strut grafts are a reliable option for treatment of pseudo-arthrosis in femoral neck fracture nonunion in children. It is successful in restoration of femoral neck length in children with non-united femoral neck fractures.
Proximal femoral osteotomy in children with cerebral palsy: The perspective of the trainee
Authors: Zhou L. , Camp M. , Gahukamble A. , Willoughby K. L. , Harambasic M. , Molesworth C. , Khot A. , Graham H. K. 
Published: February 2017

Background There are a range of implants for fixation of proximal femoral osteotomies (PFOs) in children. We investigated the training experiences and preferences of orthopaedic residents and fellows who were learning PFO, using a fixed angled blade plate (ABP) or a locking, cannulated blade plate (LCBP). We also studied short-term technical and radiographic outcomes. Methods This was a prospective, parallel-group, cohort study of 90 consecutive children and adolescents with cerebral palsy who underwent bilateral PFOs with ABP or LCBP. Surgical trainees completed a questionnaire to document the ease or difficulty of each operative step. Results There were 48 boys and 42 girls, with a mean age of eight years and a mean follow-up of 25 months. Trainees preferred the LCBP system for: insertion of the guidewire, the seating chisel and the blade plate, as well as overall technical ease of use (p < 0.001). Radiographic outcomes were similar with no between-group differences for migration percentage (p = 0.996) or neck shaft angle (p = 0.849), but there was a higher prevalence of technical errors in the ABP group. Conclusions Trainee surgeons expressed a preference for LCBPs when learning PFO in children with cerebral palsy. Radiographic outcomes were similar in both groups, with close attending surgeon supervision.
Periodic Variations in the Vertical Velocities of Galactic Masers
Authors: Bobylev V. V. , Bajkova A. T. , Shirokova K. S. 
Published: February 2017

Abstract
We compiled published data on Galactic masers with VLBI-measured trigonometric parallaxes and determined the residual tangential, ∆V
circ, and radial, ∆VR
, velocities for 120 masers. We used these data to redetermine the parameters of the Galactic spiral density wave using the method of spectral analysis. The most interesting result of this study is the detection of wavelike oscillations of vertical spatial velocities (W) versus distance R from the Galactic rotation axis. Spectral analysis allowed us to determine the perturbation wavelength and the amplitude of this wave, which we found to be equal to λ
W
= 3.4 ± 0.7 kpc and fW
= 4.9 ± 1.2 km s−1, respectively.
Russian Virtual Observatory: Data Sources
Authors: Malkov O. , Dluzhnevskaya O. , Bakanas E. , Kilpio E. , Kniazev A. , Kovaleva D. , Mironov A. , Pakhomov Yu. , Ryabchikova T. , Rykhlova L. , Sachkov M. , Sazonov S. , Zhukov A. 
Published: February 2017

Abstract
The purpose of this review is to analyze main directions of creation and functioning of major data sources developed by Russian astronomers or with their participation and to compare them with the worldwide trends in these fields. We discuss astronomical space missions of the past, present, and future (Astron, INTEGRAL, WSO-UV, Spectrum Roentgen Gamma, Lyra-B), high-quality photometric atlases and catalogues, and spectroscopic data sources, primarily VALD and the global VAMDC framework for the maintenance and distribution of atomic and molecular data. We describe collection, analysis, and dissemination of astronomical data on minor bodies of the Solar System and on variable stars. Also described is the project joining data for all observational types of binary and multiple stars, Binary star DataBase (BDB).
Creativity is a Label for the Aggregated, Time – Dependent, Subjective Judgments by Creators and by Adopters
Authors: Moran Seana 
Published: February 2017

Abstract
The first premise is that creativity requires a focal perceiver perspective to be determined or assigned. As criteria for perception or judgment, what we currently consider “dimensions” of creativity instead may be “precursors.” Ultimately, creativity shifts meaning for the whole culture. The second premise is that creativity requires a temporal perspective: its assessment is time-dependent on the first instance the perceiver notices. If the perceiver accepts the creative “ it,” then it is shared for others to judge it, creating a diffusion and adaptation process. The strongest form of creativity, then, is when it stands the test of time, goes beyond its own zeitgeist, and is institutionalized for future generations.