bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complement C3 and High Risk of Venous Thromboembolism: 80517 Individuals from the Copenhagen General Population Study
Authors: Nørgaard Ina , Nielsen Sune F , Nordestgaard Børge G 
Published: January 2016

AbstractBACKGROUNDComplement activation may contribute to venous thromboembolism, including deep venous thrombosis and pulmonary embolism. We tested the hypothesis that high complement C3 concentrations are associated with high risk of venous thromboembolism in the general population.METHODSWe included 80 517 individuals without venous thromboembolism from the Copenhagen General Population Study recruited in 2003–2012. Plasma complement C3 concentrations were measured at baseline, and venous thromboembolism (n = 1176) was ascertained through April 2013 in nationwide registries. No individuals were lost to follow-up.RESULTSComplement C3 concentrations were approximately normally distributed, with a mean value of 1.13 g/L (interquartile range 0.98–1.26; SD 0.21). The cumulative incidence of venous thromboembolism was higher with progressively higher tertiles of complement C3 (log-rank trend: P = 3 × 10−8): at age 80, 7%, 9%, and 11% of individuals in the first, second, and third tertiles, respectively, had developed venous thromboembolism. Multivariable-adjusted hazard ratios for venous thromboembolism compared with individuals in the first tertile were 1.36 (95% CI, 1.16–1.59) for those in the second tertile and 1.58 (1.33–1.88) for those in the third tertile. Corresponding values were 1.36 (1.16–1.60) and 1.57 (1.33–1.87) after additional adjustment for C-reactive protein and 1.27 (1.09–1.49) and 1.31(1.10–1.57) after additional adjustment for body mass index. These results were similar for deep venous thrombosis and pulmonary embolism separately. The multivariable-adjusted hazard ratio for venous thromboembolism for a 1-g/L increase in complement C3 was 2.43 (1.74–3.40).CONCLUSIONSHigh concentrations of complement C3 were associated with high risk of venous thromboembolism in the general population.
Simulating Wind Driven Waves in the Strait of Hormuz using MIKE21 (Simulasi Gelombang Angin di Selat Hormuz Menggunakan MIKE21)
Authors: Mehdiabadi Faeghe Eslami , Mehdizadeh Mehdi Mohammad , Rahbani Maryam 
Published: January 2016

Daerah pesisir di bumi adalah salah satu zona paling dinamis yang dipengaruhi oleh berbagai parameter seperti gelombang, arus, dan badai. Untuk mengelola serta mengkontrol zona tersebut adalah penting untuk mempelajari hidrodinamika daerah. Penelitian ini menggunakan MIKE 21/3 coupled Model FM untuk melihat gelombang (wind driven waves) di sekitar Pulau Larak di Selat Hormuz. Untuk mensimulasikan pola gelombang di wilayah tersebut digunakan irregular triangular grid. Pola arus di sekitar pulau dipelajari untuk jangka waktu satu tahun. Ditemukan bahwa gelombang yang ditimbulkan karena arus di sekitar pantai utara pulau relatif lemah. Terlihat pula bahwa gelombang yang ada di daerah tersebut terutama ke arah timur laut. Tinggi gelombang rata-rata di surfzone adalah sekitar 0,5 m., Dengan kecepatan arus sekitar 0,2 m.s-1. Mengingat angin menang dan arah gelombang, disimpulkan bahwa pantai utara Pulau Larak tempat yang cocok untuk konstruksi pelabuhan dan kegiatan memancing. Kata kunci: gelombang, arus, MIKE, Pulau Larak Coastal areas on earth are among the most dynamic zones which affected by different parameters such as waves, currents, and storms. To manage and control such a zone it is essential to study the hydrodynamic of the area. MIKE 21/3 Coupled Model FM was used to investigate the wind driven waves around Larak Island located in the Strait of Hormuz. To simulate the pattern of the wave in the area irregular triangular grid was applied. The pattern of current around the Island was studied for a one year period of simulation. It was found that the current induced wave break around the Northern coast of the Island is relatively weak. It was also observed that the prevailed wave in the area is mainly toward the Northeast. The averaged wave height in the surfzone is about 0.5 m., with the current velocity of about 0.2 m.s-1. Considering the prevailed wind and wave direction, it was concluded that the northern coasts of the Larak Island are suitable places for harbor construction, recreational and fishing activities. Keywords: Waves Break, Current, MIKE, Larak Island
Relationship Between Light Intensity and Abundance of Dinoflagellate in Samalona Island, Makassar (Keterkaitan Intensitas Cahaya dan Kelimpahan Dinoflagellate di Pulau Samalona, Makassar)
Authors: Tasak Albida Rante , Kawaroe Mujizat , Prartono Tri 
Published: January 2016

Cahaya merupakan salah satu faktor penting dalam proses fotosintesis dinoflagellate dan pertumbuhan variabilitas harian. Intensitas cahaya memengaruhi aktivitas fotosintesis dan kelimpahan dinoflagellate. Studi ini bertujuan untuk menunjukkan pola kecenderungan kelimpahan dinoflagellate dan klorofil serta lama penyinaran terhadap kelimpahan dinoflagellate di Perairan Pulau Samalona. Penelitian dilakukan dengan menginkubasi sampel dinoflagellate kedalam botol sejak pagi-sore hari dengan inkubasi waktu pengamatan setiap 2 jam dengan ulangan sebanyak 3 kali. Pengambilan mencakup kelimpahan dinoflagellate, nutrient dan intensitas cahaya dalam perairan. Analisis data menggunakan regresi linear sederhana. Hasil penelitian menunjukkan bahwa nilai intensitas cahaya berkisar antara 50–3000 lux; kelimpahan dinoflagellate berkisar antara 9–1105 sel.L-1, dan kandungan klorofil a lebih dominan dengan kisaran 0.00069–0.50321 µg.L-1. Intensitas cahaya mempengaruhi kelimpahan dinoflagellate, namun pengaruh kandungan nutrient sangat kecil terhadap kelimpahan dinoflagellate. Pola kelimpahan dinoflagellate bervariasi dari pagi hingga sore hari yang dipengaruhi oleh intensitas cahaya dalam melakukan proses fotosintesis serta kondisi lingkungan lain seperti klorofil a dan nutrient. Hasil penelitian ini memberikan informasi variasi temporal harian kelimpahan dinoflagellate di Pulau Samalona, Makassar.
Influence of Protein and Water Addition on Gluten-Free Dough Properties and Bread Quality
Authors: Aprodu Iuliana , Alexandra Badiu Elena , Banu Iuliana 
Published: January 2016

Abstract
The diversity and nutritional value of the gluten-free products is challenging because of the increasing segment of population with celiac disease. In order to address this issue, the effects of different proteins (powdered eggs, soy, lupin, sodium caseinate and whey) to the gluten-free formulation based on rice and maize flours were assessed. The dough hydration was varied from 55 to 105 %, and dough rheological properties and bread characteristics were tested. The nature of the proteins and water level added to the gluten-free bread recipes has a decisive role on product quality. The best results in terms of rheological behavior were recorded for samples with powdered eggs, soy and lupin protein addition, at water absorption of 95–105 %. Concerning the bread quality, our results showed that protein addition to the rice and maize flours gluten-free formulations allows the improvement of crumb texture.
BAT and Hybrid BAT Meta-Heuristic for Quality of Service-Based Web Service Selection
Authors: Podili Prashanth , Pattanaik K.K. , Rana Prashanth Singh 
Published: January 2016

AbstractEfficient QoS-based service selection from a pool of functionally substitutable web services (WS) for constructing composite WS is important for an efficient business process. Service composition based on diverse QoS requirements is a multi-objective optimization problem. Meta-heuristic techniques such as genetic algorithm (GA), particle swarm optimization (PSO), and variants of PSO have been extensively used for solving multi-objective optimization problems. The efficiency of any such meta-heuristic techniques lies with their rate of convergence and execution time. This article evaluates the efficiency of BAT and Hybrid BAT algorithms against the existing GA and Discrete PSO techniques in the context of service selection problems. The proposed algorithms are tested on the QWS data set to select the best fit services in terms of maximum aggregated end-to-end QoS parameters. Hybrid BAT is found to be efficient for service composition.
Simple estimation of reference intervals from routine laboratory data
Authors: Hoffmann Georg , Lichtinghagen Ralf , Wosniok Werner 
Published: January 2016

Abstract:
According to the recommendations of the IFCC and other organizations, medical laboratories should establish or at least adapt their own reference intervals, to make sure that they reflect the peculiar characteristics of the respective methods and patient collectives. In practice, however, this postulate is hard to fulfill. Therefore, two task forces of the DGKL (“AG Richtwerte” and “AG Bioinformatik”) have developed methods for the estimation of reference intervals from routine laboratory data. Here we describe a visual procedure, which can be performed on an Excel sheet without any programming knowledge. Patient values are plotted against the quantiles of the standard normal distribution (so-called QQ plot) using the NORM. INV function of Excel. If the examined population contains mainly non-diseased persons with approximately normally distributed values, the respective dots form a straight line. Very often the values are rather lognormally distributed; in this case the straight line can be detected after logarithmic transformation of the original values. Values, which do not match with the assumed theoretical distribution, deviate from the linear shape and can easily be identified and eliminated. Using the reduced data set, the mean value and standard deviation are calculated and the reference interval (μ±2σ) is estimated. The method yields plausible results with simulated and real data. With the increasing number of results, which do not match with the model, it tends to underestimate the standard deviation. In all cases, where the QQ plot does not yield a substantial linear part, the proposed method is not applicable.
Radioiodination and biological evaluation of levalbuterol as a new selective radiotracer: a β
2-adrenoceptor agonist
Authors: Sanad Mahmoud Hamdi , Abelrahman Mohamed Abdelmotelb , Marzook Fawzy Mohamed Abdelmaged 
Published: January 2016

Abstract
Levalbuterol was successfully radiolabeled with iodine using
chloramine-T as an oxidizing agent via an electrophilic substitution
reaction. The reaction parameters that affecting the labeling yield
such as levalbuterol concentration, chloramine-T concentration, pH of
the reaction medium and reaction time were studied in details. The
radiochemical yield was 97.5 ± 0.5% and the
radioiodinated compound was separated by HPLC. In vitro studies showed
that the iodinated levalbuterol was stable for up to
24 h. The biodistribution in experimental animals showed
that the lung uptake was 68.18 ± 0.17% at
5 min post injection which decreased with time
until reached to 18.7 ± 0.12% at 2 h
which was higher than other recent developed radiopharmaceuticals for
lung imaging. The clearance pathways from the mice appear to proceed
via both hepatobiliary and renal pathways. Predosing the mice with
cold levalbuterol reduced the lung uptake to
20 ± 1.3% and further confirms the high specificity
and selectivity of 125I-levalbuterol for the lung.
Hidden cultures in law: Metaphor and translation in legal discourse
Authors: Stefanì Paolo 
Published: January 2016

AbstractThe paper analyzes the problem of the contemporary societies, characterized by the permanent presence of people belonging to different faiths and the culture. The relationship between law and culture, law and religion, in particular the Christian religion, in the history of western culture, are the focus of the paper. In this way, the paper analyzes the importance of the interdisciplinary approach to this problem, emphasizing the importance of a dialogue between juridical science and semiotics, and the importance of the use of metaphor as a strategy for building an intercultural legal system. This approach at juridical studies allows one to stem the crisis of the “modern” legal system. It is necessary to recovering the authentic sense of generalizations and abstractions of modern law, to create a society based on dialogue between law, culture, and religion, and to go beyond the logic of multiculturalism. To do this, is necessary to realize that words such as freedom, equality, dignity, and autonomy are communication code-words with extraordinary symbolic and political value. To do this, we will need to combine the work of interpretation of the law with that of intercultural translation.
Spiritualität und Religiosität in der Weiterbildung von Psychologen in Palliative Care
Authors: Berthold Daniel , Gramm Jan , Hofmann Liane 
Published: January 2016

ZusammenfassungSpiritualität und Religiosität (S / R) gewinnen im psychotherapeutischen Bereich zunehmend an Bedeutung. In besonderem Maße gilt dies für den Anwendungsbereich Palliative Care. Unklar ist, inwieweit S / R bislang Gegenstand jener Weiterbildungen sind, die von Psychologen in Palliative Care typischerweise absolviert werden. Es wurden daher im Palliativbereich tätige Psychologen danach befragt, welche Aus- und Weiterbildungen sie durchlaufen haben, welchen Stellenwert S / R darin hatten und inwiefern dies ihren Bedürfnissen entsprach. Im Anschluss an eine Diskussion der Ergebnisse sollen abschließend Desiderate zukünftiger Entwicklungen aufgezeigt werden.
Existenzielle Fallbesprechung – ein Führungsinstrument zur Entlastung Pflegender
Authors: Ehm Simone 
Published: January 2016

ZusammenfassungUm Belastungen Pflegender zu reduzieren, hat das Albertinen-Diakoniewerk in Hamburg eine „existenzielle Fallbesprechung“ eingeführt. Akzeptanz und Wirkung wurden in einer qualitativen Interviewstudie analysiert. Im Beitrag werden ausgewählte Ergebnisse zur Anwendung und zu belastungsreduzierenden Wirkfaktoren des Angebots vorgestellt. Deutlich wird, dass Fallbesprechungen über verschiedene Nutzungsformen und Wirkmechanismen dazu beitragen, Pflegende im Umgang mit kritischen Ereignissen zu stärken. Das flexible Instrument verankert im Unternehmen die Möglichkeit zur Unterbrechung des Berufsalltags und zur Reflexion hochindividueller existenzieller Erfahrungen. Gegenüber anderen Angeboten wie Supervision oder Seelsorge hat das Führungsinstrument aus Perspektive Pflegender Vorteile, da es auf eine parallele Entwicklung von Person und Kliniksystem angelegt ist.
Der Dreiklang von Spiritualität, Existenzieller Kommunikation und Selbstsorge – Gottesliebe, Nächstenliebe und Selbstliebe – in der Personal- und Organisationsentwicklung von (diakonischen) Pflegesettings
Authors: Giebel Astrid 
Published: January 2016

ZusammenfassungDie Begleitung von Menschen in existenziellen Situationen ist der Kernauftrag der diakonischen Pflege. Grundvoraussetzung ist die Stärkung von Beziehungen – einer beziehungsorientierten Pflege. Dabei findet Gottesliebe in gelebter Spiritualität, Selbstliebe in der Selbstsorge und Nächstenliebe in existenzieller Begleitung bei Krankheit und Hilfebedürftigkeit ihren Ausdruck. Das Curriculum Existenzielle Kommunikation, Spiritualität und Selbstsorge im Pflegeberuf – DiakonieCare zielt auf ein neues Pflegeverständnis, eine neue Pflegebewegung. Damit diakonische Pflege gelebt und erfahren werden kann, ist eine wichtige Bedingung, dass sie in den diakonischen Einrichtungen an entsprechende Prozesse, Strukturen und eine diakonisch geprägte Kultur anknüpfen kann.
Fatigue Life Prediction of Low Pressure Turbine Shaft of Turbojet Engine
Authors: Yu Le , Chen Hao , Zhou Jie , Yin Hengsu , Huang Hong-Zhong 
Published: January 2016

AbstractThe fatigue life prediction method of a low pressure turbine shaft of the turbojet engine is presented. According to working conditions and assembled conditions of the turbojet engine, load types, load values and constraints of the turbine shaft are analyzed. ANSYS software is employed to simulate actual working conditions to obtain stress-strain distributions of the low pressure turbine shaft. Finally, based on stress-strain curves and surface quality, the fatigue life of the low-pressure turbine shaft is calculated with the modified local stress-strain method and the linear cumulative fatigue damage model.
Structural, Electronic, Magnetic and Optical Properties of Ni,Ti/Al-based Heusler Alloys: A First-Principles Approach
Authors: Adebambo Paul O. , Adetunji Bamidele I. , Olowofela Joseph A. , Oguntuase James A. , Adebayo Gboyega A. 
Published: January 2016

AbstractIn this work, detailed first-principles calculations within the generalised gradient approximation (GGA) of electronic, structural, magnetic, and optical properties of Ni,Ti, and Al-based Heusler alloys are presented. The lattice parameter of C1bwith space groupF4̅3m(216) NiTiAl alloys is predicted and that of Ni2TiAl is in close agreement with available results. The band dispersion along the high symmetry pointsW→L→Γ→X→W→Kin Ni2TiAl and NiTiAl Heusler alloys are also reported. NiTiAl alloy has a direct band gap of 1.60 eV at Γ point as a result of strong hybridization between the d state of the lower and higher valence of both the Ti and Ni atoms. The calculated real part of the dielectric function confirmed the band gap of 1.60 eV in NiTiAl alloys. The present calculations revealed the paramagnetic state of NiTiAl. From the band structure calculations, Ni2TiAl with higher Fermi level exhibits metallic properties as in the case of both NiAl and Ni3Al binary systems.
Successful fertility treatment with gonadotrophin therapy for male hypogonadotrophic hypogonadism
Authors: Rajkanna J , Tariq S , Oyibo S O 
Published: January 2016

Summary
Gonadotrophin therapy with human chorionic gonadotrophin and recombinant FSH is indicated for use in men with reduced spermatogenesis due to hypogonadotrophic hypogonadism (HH). Patients require regular monitoring for side effects and desired response to treatment. We present a man with HH, azoospermia and a history of previous anabolic steroid usage who had undergone gonadotrophin therapy, had subsequently achieved conception and has now fathered a child.

Learning points

In total, 15% of couples do not achieve pregnancy within 1 year and seek medical treatment for infertility: male factors contribute to 50% of these.

The evaluation of male infertility should include a full history and examination, an endocrine profile and a quality-controlled semen analysis.

HH with defective spermatogenesis is an important cause of male infertility in a small percentage of cases.

Gonadotrophin therapy requires regular monitoring for side effects and desired response to treatment.

Any sustained rise in prostate specific antigen levels should prompt urological assessment for possible prostate biopsy.

A multidisciplinary approach is required for gonadotrophin therapy, especially if assisted fertilisation techniques are required once, spermatogenesis is achieved.
Alcances penales de la objeción de conciencia del médico en el aborto lícito en Colombia; Criminal Scopes of the Doctor Conscientious Objection in the Cases of Lawful Abortion in Colombia; Âmbitos penales da objeção de consciência em o médico
Authors: MENDOZA PERDOMO JUAN FRANCISCO 
Published: January 2016

<p>ResumenEl artículo realiza un análisis de la sentencia de constitucionalidad que despenalizó parcialmente el delitode aborto en Colombia y precisa conceptualmente las clases de aborto lícito y las razones que produjeronsu autorización constitucional. Bajo este marco se identifica la intervención de la actividad médica en cadaforma de aborto y sus consecuencias jurídicas. Posteriormente se revisa el concepto de objeción de concienciaen la teoría del derecho y en el derecho penal, para con ello precisar los alcances jurídico-penalesde la objeción del médico en la práctica del aborto, proponiéndose la fundamentación y estructura queesta disculpante debe seguir en la resolución de casos.</p><p>Palabras clave: aborto lícito, norma de permiso, rol del médico, objeción de conciencia</p><p>AbstractThe article analyzes the judgment of constitutionality which partially decriminalized the abortion in Colombiaand conceptually precise kinds of legal abortion and the reasons that caused its constitutional approval.Under this structure it identifies the intervention of medical activity in every form of abortion and its legalconsequences. Then we review the concept of conscientious objection in the theory of law and criminallaw, to thereby determine the criminal legal scope of objection in medical abortion practice, proposingthe foundation and configuration that this exemption must follow in resolving cases.</p><p>Keywords: Lawful abortion, license, doctor’s role, conscientious objection.</p><p>Resumo:O artigo analisa o julgamento de constitucionalidade que parcialmente descriminalizou o aborto naColômbia e tipos conceitualmente precisas de aborto legal e os motivos que provocaram a sua aprovaçãoconstitucional. Sob essa estrutura identifica a intervenção da atividade médica em toda forma de abortoe suas consequências legais. Então nós rever o conceito de objecção de consciência na teoria da lei e dodireito penal, para, assim, determinar o alcance da objeção legal criminosa na prática o aborto médico,propondo a fundação e configuração deve seguir esta isenção na resolução de casos.</p><p>Palavras-chave: Lícito o aborto, licenciar, papel médica, a objeção de consciência.</p><p> </p>