bluuebunny/crossref_metadata_2025_split huggingface dataset:
Seed‐based information retrieval in networks of research publications: Evaluation of direct citations, bibliographic coupling, co‐citations, and PubMed‐related article score
Authors: Sjögårde Peter , Ahlgren Per 
Published: September 2024

AbstractIn this contribution, we deal with seed‐based information retrieval in networks of research publications. Using systematic reviews as a baseline, and publication data from the NIH Open Citation Collection, we compare the performance of the three citation‐based approaches direct citation, co‐citation, and bibliographic coupling with respect to recall and precision measures. In addition, we include the PubMed‐related article score as well as combined approaches in the comparison. We also provide a fairly comprehensive review of earlier research in which citation relations have been used for information retrieval purposes. The results show an advantage for co‐citation over bibliographic coupling and direct citation. However, combining the three approaches outperforms the exclusive use of co‐citation in the study. The results further indicate, in line with previous research, that combining citation‐based approaches with textual approaches enhances the performance of seed‐based information retrieval. The results from the study may guide approaches combining citation‐based and textual approaches in their choice of citation similarity measures. We suggest that future research use more structured approaches to evaluate methods for seed‐based retrieval of publications, including comparative approaches as well as the elaboration of common data sets and baselines for evaluation.
Difluoroboron Complexes as Versatile Precursors for Steroid Modification. Lumiestrone‐Based Steroid Derivatives: Synthesis and Structural Studies
Authors: Sukhanova Anna A. , Prezent Mikhail A. , Minyaev Mikhail E. , Zavarzin Igor V. 
Published: September 2024

AbstractA preparation method for steroid‐based difluoroboron complexes has been developed using lumiestrone as a steroid example. Previously inaccessible lumiestrone‐based difluoroboron complexes annulated at positions 16 and 17 of the D ring have been prepared. Such difluoroboron complexes may have large synthetic potential for heterofunctionalization of steroids at the D ring. An application of a borylation mixture Ac2O‐BF3⋅OEt2 significantly simplify the preparation of steroid “dimers” bearing two estrone moieties connected at positions 2 and 2′ via a linker. Crystal structures of key representatives have been determined by X‐ray diffraction.
Zuranolone therapy protects frontal cortex neurodevelopment and improves behavioral outcomes after preterm birth
Authors: Moloney Roisin A. , Palliser Hannah K. , Pavy Carlton L. , Shaw Julia C. , Hirst Jonathan J. 
Published: September 2024

AbstractBackgroundPreterm birth is associated with brain injury and long‐term behavioral abnormalities, for which there are limited prevention options. When born preterm, infants prematurely lose placental neurosteroid (allopregnanolone) support. This increases the risk of excitotoxic damage to the brain, which increases the risk of injury, causing long‐term deficits in behavior, myelination, and alterations to neurotransmitter pathways. We propose that postnatal restoration of neurosteroid action through zuranolone therapy will reduce neurological impairments following preterm birth.Methods:Guinea pig dams underwent survival cesarean section surgery to deliver pups prematurely (GA64) or at term (GA69). Between birth and term equivalence age, preterm pups received vehicle (15% β‐cyclodextrin) or the allopregnanolone analogue zuranolone (1 mg/kg/day). Behavioral analysis was performed at postnatal day (PND) 7 and 40, before tissue collection at PND 42. Immunostaining for myelin basic protein (MBP), as well as real‐time polymerase chain reaction to characterize oligodendrocyte lineage and neurotransmitter pathways, was performed in frontal cortex tissues.Results:Zuranolone treatment prevented the hyperactive phenotype in preterm‐born offspring, most markedly in males. Additionally, preterm‐related reductions in MBP were ameliorated. Several preterm‐related alterations in mRNA expression of dopaminergic, glutamatergic, and GABAergic pathways were also restored back to that of a term control level.Conclusion:This is the first study to assess zuranolone treatment as a neuroprotective therapy following preterm birth. Zuranolone treatment improved behavioral outcomes and structural changes in the preterm offspring, which continued long term until at least a late childhood timepoint. Clinical studies are warranted for further exploring the neuroprotective possibilities of this treatment following preterm birth.
‘I feel like a weight has been lifted off of my shoulders, and more than just the haircut’: A thematic analysis exploring how the social and emotional aspects of client relationships impact upon hairdressers' psychological wellbeing
Authors: Gilius Anna , Hendry Gillian 
Published: September 2024

AbstractEmotional labour refers to the process of managing the self to fulfil the emotional requirements of a job, particularly with regard to interactions with customers, co‐workers and clients. Previous research has identified that client relationships, in particular, can lead to a strain on emotional labour. This is of particular concern for the hairdressing industry in Scotland, given that it is unregulated and consequently no formal support or essential training is provided to support hairdressers to navigate client relationships. The current study therefore sought to explore how hairdressers navigate the social and emotional aspects of client relations and how these impact upon psychological wellbeing. Interviews were conducted with seven self‐employed Scottish hairdressers before reflexive thematic analysis was applied to the data, generating themes of Safeguarding the salon via client vetting, Follow the client's lead, Supporting clients through personal problems and Social fatigue. These findings identify the unwritten but complex social process used by hairdressers to safeguard their own wellbeing and the impact that this can have when this is not accomplished. Future research should consider the impact of emotional labour on employed vs. self‐employed workers to further explore how job autonomy influences the social and emotional challenges that hairdressers experience.
A case report of massive pulmonary tuberculosis and newly diagnosed systemic lupus erythematosus with complications
Authors: Vasilj Marina , Zovko Tanja , Galic Kristina , Goluza Sesar Marija , Pejanovic Skobic Natasa , Pavlovic Katica 
Published: September 2024

Key Clinical MessageThe diagnosis of extensive pulmonary tuberculosis, especially in young people, should take into account the possibility of an associated systemic autoimmune disease. Infections remain an important cause of morbidity and mortalityin systemic lupus erythematosus. This case illustrates the importance of recognizing the association of systemic autoimmune diseases and infections and the need for a multidisciplinary approach.
Diffuse large B‐cell lymphoma with BRAFV600E mutation mimicking thyroid carcinoma in fine‐needle aspiration: A diagnostic pitfall
Authors: Xu Liming , Huang Dong Dong , Wang Jinghan , You Qihan , Yu Fang 
Published: September 2024

Key Clinical MessageWe report a rare case of thyroid diffuse large B‐cell lymphoma with a BRAFV600E mutation, which mimics poorly differentiated thyroid cancer in fine needle aspiration cytology.
Unlocking a Key Residue in a Lipase for Efficient Polyethylene Terephthalate (PET) Hydrolysis and Influencing Depolymerization Product Profiles
Authors: Vidal Paula , Robles‐Martín Ana , Fernandez‐Lopez Laura , Gonzalez‐Alfonso Jose L. , Almendral David , Muñoz‐Tafalla Ruben , Plou Francisco J. , Guallar Víctor , Ferrer Manuel 
Published: September 2024

AbstractPolyethylene terephthalate (PET) pollution is a global challenge. Advancing the bioprospecting of PET‐degrading enzymes through metagenomics and using computational and functional methods to identify key positions influencing the catalytic rate and selectivity are part of the solution. Here, we report PETase activity in the metagenomic lipase LipMRD9, which exhibits peak activity at 30 °C and pH 9.0 and has a denaturation temperature of 42 °C. In addition to acting on long‐chain triglycerides (up to ∼13 units (U)/mg, pH 8.0, 30 °C) and a wide range of 34 other esters (up to ∼228 U/g), LipMRD9 hydrolyses mono(2‐hydroxyethyl) terephthalate (∼57 U/g) and bis(2‐hydroxyethyl) terephthalate (∼131 U/g). It also efficiently deconstructs GoodFellow amorphous submicro‐ and nanosized PET particles (∼984/2238 μM degradation products at 30/40 °C, pH 7.0, 21.5 h) and films (∼112/198 μM degradation products at 30/40 °C, pH 7.0, 7 days). Through molecular modelling and experimental analysis, the active site of LipMRD9 was revealed, identifying a key residue contributing to its PETase activity compared with those of its closest homologues. This residue plays a crucial role in determining the distinct profiles of degradation products from PET hydrolysis and should be studied in other PETases for its influence on the catalytic process.
Serum Circulating mRNA Panel for the Early Detection of Gastric Cancer: A Potential Biomarker Test
Authors: Peng Xinyu , Teng Xiaoyan , Ma Qian , Han Da 
Published: September 2024

AbstractCirculating free messenger RNAs (cfmRNAs) in serum have emerged as potential noninvasive biomarkers for cancer diagnosis, including gastric cancer (GC). This study utilized RNA‐sequencing data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases to identify a training set of 100 differentially expressed genes (DEGs) specific to GC patients. Employing a support vector machine (SVM) classification, we narrowed down the candidate gene set to 23, which was further refined to 4 genes–DMBX1, EVX1, MAL, and PIWIL1–after validation through reverse transcription quantitative polymerase chain reaction (RT‐qPCR). The diagnostic performance of mRNA panels, particularly the combinations of DMBX1 with EVX1 and EVX1 with PIWIL1, was exceptional, achieving area under the curve (AUC) values of 0.800, sensitivities of 90.0 %, and specificities of 80.0 %. The accuracy of these biomarkers was corroborated through various machine learning algorithms, underscoring their robust diagnostic potential. The findings of this study are poised to significantly influence clinical practice by providing robust tools for early GC detection. As these biomarkers undergo further investigation and validation, they hold promise to become integral to the diagnostic for GC.
Sources of Rapid and Delayed New Lower Jaw Input in the Forepaw Barrel Subfield (FBS) in Rat Primary Somatosensory Cortex (SI) Following Forelimb Deafferentation
Authors: Pellicer‐Morata Violeta , Wang Lie , Curry Amy de Jongh , Tsao Jack W. , Waters Robert S. 
Published: September 2024

ABSTRACTPreviously, we reported an immediate emergence of new lower jaw input to the anterior forepaw barrel subfield (FBS) in primary somatosensory cortex (SI) following forelimb deafferentation. However, a delay of 7 weeks or more post‐amputation results in the presence of this new input to both anterior and posterior FBS. The immediate change suggests pre‐existing latent lower jaw input in the FBS, whereas the delayed alteration implies the involvement of alternative sources. One possible source for immediate lower jaw responses is the neighboring lower jaw barrel subfield (LJBSF). We used anatomical tracers to investigate the possible projection of LJBSF to the FBS in normal and forelimb‐amputated rats. Our findings are as follows: (1) anterograde tracer injection into LJBSF in normal and amputated rats labeled fibers and terminals exclusively in the anterior FBS; (2) retrograde tracer injection in the anterior FBS in normal and forelimb‐amputated rats, heavily labeled cell bodies predominantly in the posterior LJBSF, with fewer in the anterior LJBSF; (3) retrograde tracer injection in the posterior FBS in normal and forelimb‐amputated rats, sparsely labeled cell bodies in the posterior LJBSF; (4) retrograde tracer injection in anterior and posterior FBS in normal and forelimb‐amputated rats, labeled cells exclusively in ventral posterior lateral (VPL) nucleus and posterior thalamus (PO); (5) retrograde tracer injection in LJBSF‐labeled cell bodies exclusively in ventral posterior medial thalamic nucleus and PO. These findings suggest that LJBSF facilitates rapid lower jaw reorganization in the anterior FBS, whereas VPL and/or other subcortical sites provide a likely substrate for delayed reorganization observed in the posterior FBS.
Tunable Properties of Non‐Volatile Magnetic Mixtures on Different Surfaces
Authors: Abellán‐Martín Sergio J. , Zapater Cristina , González‐Gallardo Nerea , Aguirre Miguel Ángel , Vidal Lorena , Ramón Diego J. , Canals Antonio 
Published: September 2024

AbstractIn this work, the surface nature‐dependent behaviors of magnetic deep eutectic solvents (MDESs) and magnetic low‐transition‐temperature non‐volatile mixtures (MLTTMs) are reported for the first time. It has been observed that the surface of the material where the MDES or the MLTTM is placed could considerably affect the dispersion and the magnetic and structural properties of these magnetic mixtures. Different techniques and analyses have been carried out to highlight the differences observed in the properties depending on the material on which these magnetic mixtures are placed. To that end, differential scanning calorimetry (DSC), surface tension, contact angle and scanning electron microscopy with energy dispersive X‐ray spectroscopy (SEM‐EDX) measurements have been performed. As a result, it has been shown that the MDESs or MLTTMs are retained and adhered to glass surfaces, resulting in a loss of magnetism of the mixture in addition to a loss in the performance of synthesis carried out on the closeness of glass materials as the interaction between the glass and the mixture modify the composition and therefore the properties. As a preliminary result, when using these magnetic mixtures as extractant solvents in dispersive liquid‐liquid microextraction, the MDES or MLTTM is retained on the walls of the glass tubes reducing the extraction efficiency, repeatability and the extraction recovery using an external magnetic field. For all these reasons, polypropylene materials should be recommended when handling magnetic deep eutectic solvents and non‐volatile MLTTMs.
Fasudil attenuates syncytin‐1‐mediated activation of microglia and impairments of motor neurons and motor function in mice
Authors: Mao Mei , Zeng Wen , Zheng Yan , Fan Wen , Yao Yuanrong 
Published: September 2024

AbstractAmyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. Syncytin‐1 (Syn), an envelope glycoprotein encoded by the env gene of the human endogenous retrovirus‐W family, has been resorted to be highly expressed in biopsies from the muscles from ALS patients; however, the specific regulatory role of Syn during ALS progression remains uncovered.In this study, C57BL/6 mice were injected with adeno‐associated virus‐overexpressing Syn, with or without Fasudil administration. The Syn expression was assessed by quantitative real‐time polymerase chain reaction and immunohistochemistry analysis. The histological change of anterior tibial muscles was determined by hematoxylin‐eosin staining. Qualitative ultrastructural analysis of electron micrographs obtained from lumbar spinal cords was carried out. Serum inflammatory cytokines were assessed by enzyme linked immunosorbent assay (ELISA) assay and motor function was recorded using Basso, Beattie, and Bresnahan (BBB) scoring, climbing test and treadmill running test. Immunofluorescence and western blot assays were conducted to examine microglial‐ and motor neurons‐related proteins.Syn overexpression significantly caused systemic inflammatory response, muscle tissue lesions, and motor dysfunction in mice. Meanwhile, Syn overexpression promoted the impairment of motor neuron, evidenced by the damaged structure of the neurons and reduced expression of microtubule‐associated protein 2, HB9, neuronal nuclei and neuron‐specific enolase in Syn‐induced mice. In addition, Syn overexpression greatly promoted the expression of CD16/CD32 and inducible nitric oxide synthase (M1 phenotype markers), and reduced the expression of CD206 and arginase 1 (M2 phenotype markers). Importantly, the above changes caused by Syn overexpression were partly abolished by Fasudil administration.This study provides evidence that Syn‐activated microglia plays a pivotal role during the progression of ALS.
Biphenylsulfonamides as effective MMP‐2 inhibitors with promising antileukemic efficacy: Synthesis, in vitro biological evaluation, molecular docking, and MD simulation analysis
Authors: Baidya Sandip K. , Patel Tarun , Himaja Ambati , Banerjee Suvankar , Das Sanjib , Ghosh Balaram , Jha Tarun , Adhikari Nilanjan 
Published: September 2024

AbstractOverexpression of matrix metalloproteinase‐2 (MMP‐2) possesses a correlation with leukemia especially chronic myeloid leukemia (CML). However, no such MMP‐2 inhibitor has come out in the market to date for treating leukemia. In this study, synthesis, biological evaluation, and molecular modeling studies of a set of biphenylsulfonamide derivatives as promising MMP‐2 inhibitors were performed, focusing on their potential applications as antileukemic therapeutics. Compounds DH‐18 and DH‐19 exerted the most effective MMP‐2 inhibition (IC50 of 139.45 nM and 115.16 nM, respectively) with potent antileukemic efficacy against the CML cell line K562 (IC50 of 0.338 µM and 0.398 µM, respectively). The lead molecules DH‐18 and DH‐19 reduced the MMP‐2 expression by 21.3% and 17.8%, respectively with effective apoptotic induction (45.4% and 39.8%, respectively) in the K562 cell line. Moreover, both these compounds significantly arrested different phases of the cell cycle. Again, both these molecules depicted promising antiangiogenic efficacy in the ACHN cell line. Nevertheless, the molecular docking and molecular dynamics (MD) simulation studies revealed that DH‐18 formed strong bidentate chelation with the catalytic Zn2+ ion through the hydroxamate zinc binding group (ZBG). Apart from that, the MD simulation study also disclosed stable binding interactions of DH‐18 and MMP‐2 along with crucial interactions with active site amino acid residues namely His120, Glu121, His124, His130, Pro140, and Tyr142. In a nutshell, this study highlighted the importance of biphenylsulfonamide‐based novel and promising MMP‐2 inhibitors to open up a new avenue for potential therapy against CML.
Effects of Peripubertal Experiences on Competitive Behavior in Male Rats at Different Stages of Adulthood
Authors: Huang Jinkun , Yang Wenjia , Bao Lili , Yin Bin 
Published: September 2024

ABSTRACTPast studies in animal models have extensively investigated the impact of early life experiences on behavioral development, yet relatively few have specifically examined the implications of peripubertal experiences on the evolution of competitive behavior across distinct stages of adulthood. In the current research, we probed potential differences in competitive behavior during emerging adulthood (3 months old) and middle adulthood (12 months old) in 81 Sprague‐Dawley male rats exposed to three different peripubertal (postnatal Days 37–60) environments: an enriched environment (EE), a chronic unpredictable mild stress (CUMS) condition, and a control condition. Anxiety‐like behavior served as a positive control in our study. Results revealed significant variations in competitive behavior among the groups during emerging adulthood. The EE group displayed the least anxiety and outperformed their peers in food‐reward‐oriented competition, whereas the CUMS group excelled in status‐driven, agonistic competition. However, these behavioral differentiations gradually attenuated by middle adulthood, at which point the control group began to show an advantage. Our findings suggest that although peripubertal experiences significantly shape competitive behavior in the emerging adulthood stage, this effect diminishes over time and is nearly non‐detectable during mid‐adulthood, underscoring the fluidity of behavioral development and demonstrating that the effects of peripubertal experiences can be modulated by subsequent life experiences.
Evaluating the Use of the Penman–Monteith and Priestley–Taylor Algorithms for Modelling Peatland Evapotranspiration Using the Cold Regions Hydrological Model
Authors: Van Huizen Brandon , Petrone Richard M. , Fang Xing , Pomeroy John W. 
Published: September 2024

ABSTRACTMethods used to quantify evapotranspiration (ET) from Sphagnum‐dominated peatlands often assume that soil moisture is not a limiting factor; actual ET (AET) equals potential ET (PET). However, soil moisture can become limiting as peatlands dry, lowering AET below PET and necessitating the use of a surface resistance term in AET estimations. Quantifying and calculating surface resistance is a challenge for the non‐vascular plant surfaces such as those dominated by Sphagnum moss. This paper explores and quantifies the ecohydrological processes that drive Sphagnum resistance to ET. It is hypothesized that a relationship exists between the Sphagnum moss resistance and the ratio of unsaturated to saturated hydraulic conductivity (K‐ratio) for boreal peatlands, where the K‐ratio is a proxy for the hydrophysical properties of the porous medium. An empirical relationship between Sphagnum moss resistance and the K‐ratio was developed from data collected from a boreal peatland and implemented in the cold regions hydrological model. Empirically modelled resistance values (0–800 s m−1) did not match well with estimates from inverting observations and the Penman–Monteith (PM) algorithm (0–5000 s m−1). Difficulties in validating resistance values were possibly due to lack of moisture limiting conditions although this is seemingly contradicted by the alpha value being less than 1. Priestley–Taylor (PT) and PM algorithms in CRHM were used to estimate AET and compared with each other and with observations from an onsite eddy covariance (EC) system. The PT algorithm, using a site‐specific alpha value (0.75) performed the best with a mean difference of 9.4% (±12.0%) when compared to EC measurements of AET. The PM algorithm consistently overestimated EC measurements with a mean difference of 68.4% (±50.0%), even with a moss resistance incorporated into its use. The performance of PM algorithm is impeded by the uncertainty in quantifying Sphagnum resistance. Reducing this uncertainty should be a focus of future studies, as it does not require the use of a site‐specific alpha value.