bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do Regional Brain Volumes and Major Depressive Disorder Share Genetic Architecture?: a study of Generation Scotland (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766)
Authors: Wigmore Eleanor M. , Clarke Toni-Kim , Adams Mark J. , Fernandez-Pujals Ana M. , Gibson Jude , Howard David M. , Davies Gail , Hall Lynsey S. , Zeng Yanni , Thomson Pippa A. , Hayward Caroline , Smith Blair H. , Hocking Lynne J. , Padmanabhan Sandosh , Deary Ian J. , Porteous David J. , Nicodemus Kristin K. , McIntosh Andrew M. 
Published: June 2016

AbstractMajor depressive disorder (MDD) is a heritable and highly debilitating condition. It is commonly associated with subcortical volumetric abnormalities, the most replicated of these being reduced hippocampal volume. Using the most recent published data from ENIGMA consortium’s genome-wide association study (GWAS) of regional brain volume, we sought to test whether there is shared genetic architecture between 8 subcortical brain volumes and MDD. Using LD score regression utilising summary statistics from ENIGMA and the Psychiatric Genomics Consortium, we demonstrated that hippocampal volume was positively genetically correlated with MDD (rG=0.46, P=0.02), although this did not survive multiple comparison testing. None of other six brain regions studied were genetically correlated and amygdala volume heritability was too low for analysis. We also generated polygenic risk scores (PRS) to assess potential pleiotropy between regional brain volumes and MDD in three cohorts (Generation Scotland; Scottish Family Health Study (n=19,762), UK Biobank (n=24,048) and the English Longitudinal Study of Ageing (n=5,766). We used logistic regression to examine volumetric PRS and MDD and performed a meta-analysis across the three cohorts. No regional volumetric PRS demonstrated significant association with MDD or recurrent MDD. In this study we provide some evidence that hippocampal volume and MDD may share genetic architecture, albeit this did not survive multiple testing correction and was in the opposite direction to most reported phenotypic correlations. We therefore found no evidence to support a shared genetic architecture for MDD and regional subcortical volumes.
Development of an automated aircraft subsystem architecture generation and analysis tool
Authors: Judt David Manuel , Lawson Craig 
Published: June 2016

Purpose
– The purpose of this paper is to present a new computational framework to address future preliminary design needs for aircraft subsystems. The ability to investigate multiple candidate technologies forming subsystem architectures is enabled with the provision of automated architecture generation, analysis and optimization. Main focus lies with a demonstration of the frameworks workings, as well as the optimizers performance with a typical form of application problem.

Design/methodology/approach
– The core aspects involve a functional decomposition, coupled with a synergistic mission performance analysis on the aircraft, architecture and component levels. This may be followed by a complete enumeration of architectures, combined with a user defined technology filtering and concept ranking procedure. In addition, a hybrid heuristic optimizer, based on ant systems optimization and a genetic algorithm, is employed to produce optimal architectures in both component composition and design parameters. The optimizer is tested on a generic architecture design problem combined with modified Griewank and parabolic functions for the continuous space.

Findings
– Insights from the generalized application problem show consistent rediscovery of the optimal architectures with the optimizer, as compared to a full problem enumeration. In addition multi-objective optimization reveals a Pareto front with differences in component composition as well as continuous parameters.

Research limitations/implications
– This paper demonstrates the frameworks application on a generalized test problem only. Further publication will consider real engineering design problems.

Originality/value
– The paper addresses the need for future conceptual design methods of complex systems to consider a mixed concept space of both discrete and continuous nature via automated methods.
Combined finite-discrete element method modeling of rockslides
Authors: Zhou Wei , Yuan Wei , Ma Gang , Chang Xiao-Lin 
Published: June 2016

Purpose
– The purpose of this paper is to propose a novel combined finite-discrete element method (FDEM), based on the cohesive zone model, for simulating rockslide problems at the laboratory scale.

Design/methodology/approach
– The combined FDEM is realized using ABAQUS/Explicit. The rock mass is represented as a collection of elastic bulk elements glued by cohesive elements with zero thickness. To reproduce the tensile and shear micro-fractures in rock material, the Mohr-Coulomb model with tension cut-off is employed as the damage initiation criterion of cohesive elements. Three simulated laboratory tests are considered to verify the capability of combined FDEM in reproducing the mechanical behavior of rock masses. Three slope models with different joint inclinations are taken to illustrate the application of the combined FDEM to rockslide simulation.

Findings
– The results show that the joint inclination is an important factor for inducing the progressive failure behavior. With a low joint inclination, the slope failure process is observed to be a collapse mode. As the joint inclination becomes higher, the failure mode changes to sliding and the steady time of rock blocks is shortened. Moreover, the runout distance and post-failure slope angle decrease as the joint inclination increases.

Originality/value
– These studies indicate that the combined FDEM performed within ABAQUS can simulate slope stability problems for research purposes and is useful for studying the slope failure mechanism comprehensively.
Accurate assessment of natural frequencies for uniform and non-uniform Euler-Bernoulli beams and frames by adaptive generalized finite element method
Authors: Arndt Marcos , Machado Roberto Dalledone , Scremin Adriano 
Published: June 2016

Purpose
– The purpose of this paper is devoted to present an accurate assessment for determine natural frequencies for uniform and non-uniform Euler-Bernoulli beams and frames by an adaptive generalized finite element method (GFEM). The present paper concentrates on developing the C1 element of the adaptive GFEM for vibration analysis of Euler-Bernoulli beams and frames.

Design/methodology/approach
– The variational problem of free vibration is formulated and the main aspects of the adaptive GFEM are presented and discussed. The efficiency and convergence of the proposed method in vibration analysis of uniform and non-uniform Euler-Bernoulli beams are checked. The application of this technique in a frame is also presented.

Findings
– The present paper concentrates on developing the C1 element of the adaptive GFEM for vibration analysis of Euler-Bernoulli beams and frames. The GFEM, which was conceived on the basis of the partition of unity method, allows the inclusion of enrichment functions that contain a priori knowledge about the fundamental solution of the governing differential equation. The proposed enrichment functions are dependent on the geometric and mechanical properties of the element. This approach converges very fast and is able to approximate the frequency related to any vibration mode.

Originality/value
– The main contribution of the present study consisted in proposing an adaptive GFEM for vibration analysis of Euler-Bernoulli uniform and non-uniform beams and frames. The GFEM results were compared with those obtained by the h and p-versions of FEM and the c-version of the CEM. The adaptive GFEM has shown to be efficient in the vibration analysis of beams and has indicated that it can be applied even for a coarse discretization scheme in complex practical problems.
MHD flow of a non-Newtonian nanofluid over a non-linearly stretching sheet in the presence of thermal radiation with heat source/sink
Authors: Macha Madhu , Naikoti Kishan , Chamkha Ali J 
Published: June 2016

Purpose
– The purpose of this paper is to analyze the mangnetohydrodynamic boundary layer flow of a viscous, incompressible and electrically conducting non-Newtonian nanofluid obeying power-law model over a non-linear stretching sheet under the influence of thermal radiation with heat source/sink.

Design/methodology/approach
– The transverse magnetic field is applied normal to the sheet. The model used for the nanofluid incorporates the effects of Brownian motion with thermophoresis in the presence of thermal radiation. On this regard, thermophoresis effect on convective heat transfer on nanofluids are investigated simultaneously. The governing partial differential equations are reduced to ordinary differential equations by suitable similarity transformations which are solved numerically by variational finite element method.

Findings
– The computations carried out for some values of the power-law index, magnetic parameter, radiation parameter, Brownian motion and thermophoresis. The effect of these parameters on the velocity, temperature and nanoparticle volume fraction distribution are presented graphically. The skin friction coefficient, Nusselt number and Sherwood number for various values of the flow parameters of the problem are also presented.

Originality/value
– To the best of the authors’ knowledge, no investigations has been reported regarding the study of non-Newtonian nanofluids which obeying power-law model over a nonlinear stretching sheet. The principal aim of this paper is to study the boundary layer MHD flow of a non-Newtonian power-law model over a non-linear stretching sheet on a quotient viscous incompressible electrically conducting with a nanofluid.
Effects of material hardening model and lumped-pass method on welding residual stress simulation of J-groove weld in nuclear RPV
Authors: Liu Chuan , Luo Ying , Yang Min , Fu Qiang 
Published: June 2016

Purpose
– The purpose of this paper is to clarify the effect of material hardening model and lump-pass method on the thermal-elastic-plastic (TEP) finite element (FE) simulation of residual stress induced by multi-pass welding of materials with cyclic plasticity.

Design/methodology/approach
– Nickel-base alloy and stainless steel, which are used in J-type weld for manufacturing the nuclear reactor pressure head, can easily harden during multi-pass welding. The J-weld welding experiment is carried out and the temperature cycle and residual stress are measured to validate the TEP simulation. Thermal-mechanical sequence coupling method is employed to get the welding residual stress. The lumped-pass model and pass-by-pass FE model are built and two materials hardening models, kinematic hardening model and mixed hardening model, are adopted during the simulations. The effects of material hardening models and lumped-pass method on the residual stress in J-weld are distinguished.

Findings
– Based on the kinematic hardening model, the stresses simulated with the lumped-pass FE model are almost consistent with those obtained by the pass-by-pass FE model; while with the mixed hardening material model, the lumped-pass method has great effect on the simulated stress.

Practical implications
– A computation with mixed isotropic-kinematic material seems not to be the appropriate solution when using the lumped-pass method to save the computation time.

Originality/value
– In the simulation of multi-pass welding residual stress involved in materials with cyclic plasticity, the material hardening model should be carefully considered. The kinematic hardening model with lump-pass FE model can be used to get better simulation results with less computation time. The results give a direction for welding residual stress simulation for the large structure such as the reactor pressure vessel.
Flow stress identification of tubular materials using the progressive inverse identification method
Authors: Asaadi Erfan , Heyns P. Stephan 
Published: June 2016

Purpose
– The purpose of this paper is to propose a progressive inverse identification algorithm to characterize flow stress of tubular materials from the material response, independent of choosing an a priori hardening constitutive model.

Design/methodology/approach
– In contrast to the conventional forward flow stress identification methods, the flow stress is characterized by a multi-linear curve rather than a limited number of hardening model parameters. The proposed algorithm optimizes the slopes and lengths of the curve increments simultaneously. The objective of the optimization is that the finite element (FE) simulation response of the test estimates the material response within a predefined accuracy.

Findings
– The authors employ the algorithm to identify flow stress of a 304 stainless steel tube in a tube bulge test as an example to illustrate application of the algorithm. Comparing response of the FE simulation using the obtained flow stress with the material response shows that the method can accurately determine the flow stress of the tube.

Practical implications
– The obtained flow stress can be employed for more accurate FE simulation of the metal forming processes as the material behaviour can be characterized in a similar state of stress as the target metal forming process. Moreover, since there is no need for a priori choosing the hardening model, there is no risk for choosing an improper hardening model, which in turn facilitates solving the inverse problem.

Originality/value
– The proposed algorithm is more efficient than the conventional inverse flow stress identification methods. In the latter, each attempt to select a more accurate hardening model, if it is available, result in constructing an entirely new inverse problem. However, this problem is avoided in the proposed algorithm.
Improving customer satisfaction by increasing the reach: Life Insurance Corporation of India
Authors: Raman Prashant 
Published: June 2016

Subject area
Strategic Management and Marketing.

Study level/applicability
Management students (MBA).

Case overview
In the present times of global competition and busy schedules of individuals, it is expected that companies provide service with security, sincerity and flexibility keeping pace with changing global scenario of marketing. Service receiver expects competitive and optimum facilities with ease while sitting in any corner of the world at any time of the day. It implies that the service provider should be available at all times/all places for satisfying the needs of the customers. A daunting task ahead of Life Insurance Corporation of India (LIC) was to change its conventional approach and work toward a newer, user-friendly one. The top management, i.e. the Board of Directors, took up the task of identifying a quicker but securer approach to provide optimum facilities to the policyholders.

Expected learning outcomes
Achieving customer satisfaction through alternate collection channels and retaining market share, role of customer servicing in creating competitive advantage, challenges for a large public sector enterprise – traditional approach or modern approach, role of private companies in development of insurance industry, creating awareness about the product/service through different distribution channels and use of information and telecommunication technologies to reach remote places, are the expected learning outcomes.

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 8: Marketing
Pediasure: children’s health problem now a history!
Authors: Baig Farah Naz 
Published: June 2016

Subject area
Advertising, Marketing Management, Integrated Marketing Communications.

Study level/applicability
Undergraduate third year/fourth year students. The case is positioned at the beginning of the course.

Case overview
The case aims to help the students in understanding the concepts of push and pull marketing in the nutritional supplement category which is different from the FMCG sector in terms of the decision-making process and consumer behavior. The brand is bought by the mother, consumed by the kids and endorsed by the doctors. The brand manager faces the dilemma of budget division on push vs pull marketing considering the previous back lash from the doctors when the company shifted toward pull marketing.

Expected learning outcomes
By the end of the case, the students should have understood the following concepts: push versus pull marketing, decision-making unit, decision-making process and customer acquisition vs retention efforts.

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.

Subject code
CSS 8: Marketing
An exploratory conceptualization of consumer design perception for digital devices
Authors: Mishra Abhishek 
Published: June 2016

Purpose
Despite the volume of work on the subject, product design and its conceptualization has remained relatively abstract. There is hardly any discussion about the holistic meaning of design, especially with regards to its meaning for a user. This paper aims to explore consumer design perception to provide it a multidimensional definition and measure that is more relevant to industrial designers.

Design/methodology/approach
The study was done in two qualitative phases: the first to generate and confirm the design dimensions pre-conceived from literature, corroborated with consumer voices; and the second to include gamified depth interviews triangulated with conventional depth interviews and word association-based correspondence analysis to generate items that can measure each of those dimensions.

Findings
The first study confirms five dimensions of consumer design perception: visual, functional, kinesthetic, interface and information. Following the second phase, the study proposes five items for visual design, seven for functional design, three for kinesthetic design, four for interface design and five for information design.

Research limitations/implications
Though through multiple qualitative studies, combined with literary evidence, this work provides reasonable qualitative validity to the findings, a semiotic analysis-based methodologies that can further concretize, if not refute, the findings. Rooted in the theory of design value, the study explores transformation of design values, from the designer’s domain to that of a consumer. While each of the design constructs has gone through a thorough investigation in literature, this work is the first to provide a unified theory of consumer design perception.

Practical implications
Designers have long struggled to know what consumers want. There is a clear divide in designers and consumers’ meanings of design. This study attempts to bridge this divide. Items measuring each construct should enable them in tweaking their offerings to a consumer’s liking.

Originality/value
Design is an abstract term and can be applied by a designer or a consumer. Dimensionalization of this complex term for better understanding using innovative qualitative tools serves as an original contribution to field of design research.
The relationship between risk aversion, brand trust, brand affect and loyalty
Authors: Kumar Mishra Mukesh , Kesharwani Ankit , Das Dolly 
Published: June 2016

Purpose
The purpose of this paper is to explore the relationship among risk aversion, brand trust, brand affect, attitudinal loyalty and behavioral loyalty for low involvement day-to-day use of personal care products.

Design/methodology/approach
To achieve the above-stated objective, a theoretical model was tested using structural equation modeling. Before undertaking the analysis, preliminary analysis techniques such as the common method bias social desirability bias reliability and validity analysis were also assessed.

Findings
The results indicate that, for low involvement products, risk adverse consumers do not purchase a brand based only on trust. Risk aversion is also positively associated with attitudinal loyalty. When it comes to the relationship between brand trust and brand affect, it has been concluded that brand trust has had an important impact on brand affect. In this study, it has been found that attitudinal loyalty has a positive and strong impact on behavioral loyalty. This paper explains that due to the lack of trust, certain risk adverse customers are sticking with a particular brand.

Originality/value
Most of the brand loyalty research has been performed on high involvement products, whereas very limited research is available on low involvement day-to-day use products (i.e. personal care products), in particular where the consumption period of the product is less than a month. This kind of research is very rare, and this study has been done to fill this gap using rigorous data analysis.
A decision matrix approach to green project management processes
Authors: Al-Tekreeti Mustafa Sahban , Beheiry Salwa Mamoun 
Published: June 2016

Purpose– The purpose of this paper is to develop a decision matrix for green project management processes (GPMPs) in commercial construction projects. GPMPs can assist in decoding all of the information required to make green-conscious decisions at various stages of a project.Design/methodology/approach– Integrate the environmental factors into the traditional project management processes (PMPs) of major construction projects. The integrated product is worked into a process index, and the analytical hierarchy processes (AHP) method is used to prioritize the GPMPs according to pre-set criteria.Findings– Research established the theoretical backing of green practices integration in the traditional PMPs, by creating an AHP weighted GPMP index that is linked to usable decision matrix.Originality/value– Develops a fresh methodology to facilitate green decision-making in the project management of commercial construction projects.