bluuebunny/crossref_metadata_2025_split huggingface dataset:
Giving information about the contraceptive implant using a DVD: is it acceptable and informative? A pilot randomised study
Authors: Michie Lucy , Cameron Sharon T , Glasier Anna , Johnstone Anne 
Published: July 2016

BackgroundTo provide standardised information about the contraceptive implant (Nexplanon®), a digital video disc (DVD) was developed for use within a sexual and reproductive health (SRH) service in Edinburgh. The aim was to determine if the accuracy of information recalled after watching a DVD was comparable to that following a face-to-face consultation, and if patients found the use of a DVD acceptable.MethodsFifty women attending an SRH service abortion clinic considering using Nexplanon for the first time agreed to be randomised to receive information about the implant either by (a) a DVD (n=35) developed using information taken from Faculty of Sexual & Reproductive Healthcare guidance or (b) a face-to-face consultation (n=15). A structured interview was conducted immediately following the DVD/face-to-face consultation and by telephone 3 months later. A small number of participants from each group attended for in-depth interview.ResultsKnowledge recall (e.g. expected side effects) immediately following each intervention was similar in both groups. Most of the women who watched the DVD felt it was helpful (89%), easy to understand (94%) and acceptable (69%). Subsequently 76% of participants were contacted successfully at 3 months. The majority of those who had watched the DVD agreed that it had been informative (93%) and would be happy to receive contraceptive information via a DVD in future (93%).ConclusionsThe use of a DVD to provide patient information on Nexplanon is acceptable and informative, and may enhance patient consultations. A large randomised controlled trial may determine if provision of quality standardised information via DVD can improve uptake or continuation rates of long-acting reversible methods of contraception.
Screening of Conditionally Reprogrammed Patient-Derived Carcinoma Cells Identifies ERCC3–MYC Interactions as a Target in Pancreatic Cancer
Authors: Beglyarova Natalya , Banina Eugenia , Zhou Yan , Mukhamadeeva Ramilia , Andrianov Grigorii , Bobrov Egor , Lysenko Elena , Skobeleva Natalya , Gabitova Linara , Restifo Diana , Pressman Max , Serebriiskii Ilya G. , Hoffman John P. , Paz Keren , Behrens Diana , Khazak Vladimir , Jablonski Sandra A. , Golemis Erica A. , Weiner Louis M. , Astsaturov Igor 
Published: July 2016

Abstract
Purpose: Even when diagnosed prior to metastasis, pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy with almost 90% lethality, emphasizing the need for new therapies optimally targeting the tumors of individual patients.
Experimental Design: We first developed a panel of new physiologic models for study of PDAC, expanding surgical PDAC tumor samples in culture using short-term culture and conditional reprogramming with the Rho kinase inhibitor Y-27632, and creating matched patient-derived xenografts (PDX). These were evaluated for sensitivity to a large panel of clinical agents, and promising leads further evaluated mechanistically.
Results: Only a small minority of tested agents was cytotoxic in minimally passaged PDAC cultures in vitro. Drugs interfering with protein turnover and transcription were among most cytotoxic. Among transcriptional repressors, triptolide, a covalent inhibitor of ERCC3, was most consistently effective in vitro and in vivo causing prolonged complete regression in multiple PDX models resistant to standard PDAC therapies. Importantly, triptolide showed superior activity in MYC-amplified PDX models and elicited rapid and profound depletion of the oncoprotein MYC, a transcriptional regulator. Expression of ERCC3 and MYC was interdependent in PDACs, and acquired resistance to triptolide depended on elevated ERCC3 and MYC expression. The Cancer Genome Atlas analysis indicates ERCC3 expression predicts poor prognosis, particularly in CDKN2A-null, highly proliferative tumors.
Conclusions: This provides initial preclinical evidence for an essential role of MYC–ERCC3 interactions in PDAC, and suggests a new mechanistic approach for disruption of critical survival signaling in MYC-dependent cancers. Clin Cancer Res; 22(24); 6153–63. ©2016 AACR.
Próba zbliżenia się do sacrum poprzez kino na przykładzie analizy i interpretacji drogi jurodiwego w filmie Aleksandra Sokurowa "Samotny głos człowieka"
Authors: Korycka Agnieszka Magdalena 
Published: July 2016

Attempting to approach the sacred through film as exemplified by the analysis and interpretation of the way of a yurodivy in The Lonely Voice of Man by Alexander SokurovThe author emphasises the relation between content and form in the film The Lonely Voice of Man by Alexander Sokurov, and makes a point to place the film within an interpretation space which takes into account basic anthropological categories, such as those of space, time and the human (the protagonist). The artistic devices applied in the film lead to a degradation of the image, while the symbolism present in this debut work refers to the theme of the journey of the soul. All these elements allow us to see in The Lonely Voice of Man certain aspects shared with the Orthodox icon. In this context, the story of the main character can be perceived as the way of a yurodivy (“fool-for-Christ”), who has to refrain from temptations and practice asceticism in order to attain spiritual perfection and reach the sacred. Próba zbliżenia się do sacrum poprzez kino na przykładzie analizy i interpretacji drogi jurodiwego w filmie Aleksandra Sokurowa Samotny głos człowiekaW artykule szczególną uwagę zwrócono na ukazanie związku między treścią i formą filmu Samotny głos człowieka w reżyserii Aleksandra Sokurowa oraz na umieszczenie go na płaszczyźnie interpretacyjnej uwzględniającej podstawowe kategorie antropologiczne, takie jak: przestrzeń, czas i człowiek (bohater). Stosowane w filmie środki wyrazu powodują, że obraz ulega degradacji. Symbolika obecna w filmie nawiązuje do motywu wędrówki dusz. Wszystkie elementy stanowią podstawę do tego, by odnaleźć w debiucie Sokurowa cechy nawiązujące do prawosławnej ikony. W tym kontekście historia głównego bohatera jawi się jako droga jurodiwego, który musi pokonywać pokusy i zachowywać ascezę, by osiągnąć duchową doskonałość i dotrzeć do sacrum.
Motywy wędrówki dusz i dybuka w kulturze żydowskiej i ich współczesna realizacja w twórczości Jony Wolach
Authors: Piątek Anna 
Published: July 2016

Motifs of transmigration of souls and dybbuk in Jewish culture and their contemporary implementation in the works by Yona WollachThis article describes two concepts important for Jewish mysticism – dybbuk and the transmigration of soul, and goes on to present their contemporary usage in the works by Yona Wollach. The concept of the transmigration of souls (in Hebrew: gilgul neshamot) describes a situation whereby the soul of a dead person returns to the this world and occupies a new body. In the case of the dybbuk (in Hebrew: dibuk), on the other hand, the body of a living person, who has his or her own soul, is possessed by the spirit of a dead person. The concepts of reincarnation and dybbuk played an important role not only in religious tradition but also in folklore and popular and high culture. Both became the focus of a number of artworks. The article presents fragments of the poems of the Israeli poet Yona Wollach (1944–1985), in which she describes psychological states similar to transmigration of souls and being captured by a dybbuk. The article aims to show that these poetic images are in close connection with Wollach`s concept of the human psyche. Motywy wędrówki dusz i dybuka w kulturze żydowskiej i ich współczesna realizacja w twórczości Jony WolachArtykuł przybliża dwa ważne pojęcia mistyki żydowskiej – dybuka i wędrówki dusz, a następnie ukazuje współczesne nawiązanie do nich w twórczości Jony Wolach. Pod pojęciem wędrówki dusz (hebr. gilgul neszamot) rozumie się sytuację, w której dusza zmarłego wraca do świata doczesnego i zamieszkuje w nowym ciele. Natomiast w przypadku dybuka (hebr. dibuk) dochodzi do zawładnięcia ciałem żywego człowieka, posiadającego już jedną duszę, przez ducha zmarłej wcześniej osoby. Pojęcia wędrówki dusz i dybuka odgrywały istotną rolę nie tylko w tradycji religijnej, ale i w folklorze oraz kulturze popularnej i wysokiej, stając się tematem wielu dzieł artystycznych. W tekście prezentowane są fragmenty wierszy izraelskiej poetki Jony Wolach (1944–1985), w których opisuje ona stany psychiczne zbliżone do wędrówki dusz i zawładnięcia przez dybuka. Artykuł ma na celu ukazanie, że te poetyckie obrazy pozostają w głębokim związku z podzielaną przez Wolach koncepcją ludzkiej psychiki.
The soul in the mediaeval Psalter
Authors: Lis Kinga 
Published: July 2016

The soul in the mediaeval PsalterThe paper is an attempt to examine what lies at the heart and soul of the mediaeval Psalter in the contemporaneous approach(es) to its vernacularisations. In particular, the paper investigates the applications of the mediaeval translation theory in relation to a 12th-century Anglo-Norman, a 15th-century Middle French and four 14th-century Middle English prose Psalter renditions, with a view to locate them within the spirit of the attitude to biblical translations current in the Middle Ages and against the backdrop of the position of the Psalter in the period. In practical terms, the analysis is conducted on the basis of the equivalent selection strategies for rendering four Latin nouns central to the Psalter: anima, animae ‘soul,’ cor, cordis ‘heart’ and, perhaps surprisingly, ren, renis ‘kidney’ and lumbus, lumbi ‘loins’. All cases of variation in this respect are studied closely from intra- as well as extra-textual perspectives in order to establish the possible reasons behind the divergences, as these constitute exceptions rather than the rule, even in apparently heterodox renditions. Dusza w średniowiecznym PsałterzuArtykuł stanowi próbę bliższego przyjrzenia się podstawowym zasadom średniowiecznego podejścia do tłumaczenia psałterza na języki wernakularne. Przedstawiono w nim analizę zastosowania mediewalnej teorii tłumaczeń w odniesieniu do dwunastowiecznego Psałterza anglo-normandzkiego, piętnastowiecznego Psałterza średniofrancuskiego i czterech czternastowiecznych tłumaczeń Księgi Psalmów na średnioangielski. Celem było wykazanie, w jakim stopniu analizowane teksty odzwierciedlają ówczesne podejście do tłumaczeń biblijnych w kontekście znaczenia psałterza w średniowieczu. Badanie przeprowadzone jest na podstawie doboru ekwiwalentów w tłumaczeniu czterech – niezwykle istotnych z powodu rangi tych tekstów w średniowieczu – łacińskich rzeczowników: anima, animae‚ ‘dusza’, cor, cordis‚ ‘serce’ oraz, co może zaskoczyć, ren, renis‚ ‘nerka’ i lumbus, lumbi, ‘lędźwie’. Najwięcej uwagi poświęcono ustaleniu źródła analizowanej z perspektywy zarówno intra-, jak i ekstratekstualnej wariancji w doborze odpowiedników, jako że rozbieżność w tym względzie stanowi raczej wyjątek, a nie regułę, nawet w tłumaczeniach – wydawałoby się – heterodoksyjnych.
Analysis of Tropical Storm Formation Based on Ensemble Data Assimilation and High-Resolution Numerical Simulations of a Nondeveloping Disturbance
Authors: Penny Andrew B. , Hacker Joshua P. , Harr Patrick A. 
Published: July 2016

AbstractA nondeveloping tropical disturbance, identified as TCS025, was observed during three intensive observing periods during The Observing System Research and Predictability Experiment (THORPEX) Pacific Asian Regional Campaign (T-PARC)/Tropical Cyclone Structure-2008 (TCS-08) field experiment. The low-level circulation of the disturbance was relatively weak, asymmetric, and displaced a considerable distance from the midlevel circulation. An ensemble of high-resolution numerical simulations initialized from global model analyses was used to further examine TCS025. These simulations tended to unrealistically overdevelop the TCS025 disturbance. This study extends that work by examining the impact of assimilating in situ observations of TCS025 and dual-Doppler radial velocities from the airborne Electra Doppler Radar (ELDORA) using the Data Assimilation Research Testbed (DART) ensemble data assimilation system.The assimilation of observations results in a more accurate vortex structure that is consistent with the observational analysis. In addition, forecasts initialized from the state of the ensemble after data assimilation exhibit less development than both the control simulation and an ensemble of forecasts without prior data assimilation.A composite analysis of developing and nondeveloping forecasts from the ensemble reveals that convection was more active in developing simulations, especially near the low-level circulation center. This led to larger diabatic heating rates, spinup of the low-level circulation from vorticity stretching, and greater alignment of the low- and midlevel vorticity centers. In contrast, nondeveloping simulations exhibited less convection, and the circulation was more heavily impacted by vertical wind shear.
Antibacterial activity of chemically versus enzymatic functionalized wool with ɛ-poly-L-lysine
Authors: Kaisersberger-Vincek Maja , Štrancar Janez , Kokol Vanja 
Published: July 2016

The effect of the coupling approach (chemical by using carbodiimide chemistry and grafting-to versus grafting-from synthesis routes, and enzymatic by using transglutaminase) of ɛ-poly-L-lysine (ɛPL) graft yield with wool fibers was studied and evaluated related to their antibacterial activity against gram-negative Escherichia coli and gram-positive Staphylococcus aureus bacteria, after 1–24 h of exposure. While the ɛPL applied was evaluated colorimetrically by wool staining with two acid dyes and quantitatively by evaluation of the basic groups using potentiometric titration, its orientation was determined by Fourier transform infrared spectroscopy and, for the first time, by Electron Paramagnetic Resonance spectroscopy using spin-labeled ɛPL. The highest (∼99% for E. coli versus ∼92% for S. aureus) and kinetically the fastest (in 3 h) antibacterial activity with ∼83% for E. coli versus ∼64% for S. aureus bactericidal effect was determined for the wool functionalized by the chemical grafting-to approach. Such an effect may be related to both quantitatively the highest (∼62 gɛPL/kgwool) grafting yield of ɛPL and conformationally its highly flexible “brush-like” structure. Comparably, the enzymatic coupling (∼50 gɛPL/kgwool) giving ∼95% and ∼8% reductions of E. coli and S. aureus, respectively, being additionally reduced to ∼74% and ∼78% by using the grafting-from approach (∼34 gɛPL/kgwool), was identified as the less bactericidally effective (∼63% versus ∼58%). It was also shown that a non-ionic surfactant being used in the durability testing of functionalized wool to washing adheres strongly onto the fibers, thus blocking the amino groups of ɛPL, and, as such, decreases the antibacterial efficiency of the wool, being unaffected in the case when the washing was carried out without surfactant.
Cell sources forin vitrohuman liver cell culture models
Authors: Zeilinger Katrin , Freyer Nora , Damm Georg , Seehofer Daniel , Knöspel Fanny 
Published: July 2016

In vitro liver cell culture models are gaining increasing importance in pharmacological and toxicological research. The source of cells used is critical for the relevance and the predictive value of such models. Primary human hepatocytes (PHH) are currently considered to be the gold standard for hepatic in vitro culture models, since they directly reflect the specific metabolism and functionality of the human liver; however, the scarcity and difficult logistics of PHH have driven researchers to explore alternative cell sources, including liver cell lines and pluripotent stem cells. Liver cell lines generated from hepatomas or by genetic manipulation are widely used due to their good availability, but they are generally altered in certain metabolic functions. For the past few years, adult and pluripotent stem cells have been attracting increasing attention, due their ability to proliferate and to differentiate into hepatocyte-like cells in vitro. However, controlling the differentiation of these cells is still a challenge. This review gives an overview of the major human cell sources under investigation for in vitro liver cell culture models, including primary human liver cells, liver cell lines, and stem cells. The promises and challenges of different cell types are discussed with a focus on the complex 2D and 3D culture approaches under investigation for improving liver cell functionality in vitro. Finally, the specific application options of individual cell sources in pharmacological research or disease modeling are described.
Density measurements with computed tomography in patients with extra-axial hematoma can quantitatively estimate a degree of brain compression
Authors: Nguyen Ha Son , Li Luyuan , Patel Mohit , Mueller Wade 
Published: July 2016

Background Extra-axial hematoma can cause significant brain compression. Guidelines for surgical evacuation include imaging findings (midline shift and hematoma thickness/volume) in conjunction with Glasgow Coma Scale (GCS) scores and/or intracranial pressure (ICP) monitoring. Physiologically, overall brain density should also change with compression. In our observational study, we explored whether overall brain density, defined using computed tomography Hounsfield Units (CT HU), changes after surgical evacuation of extra-axial hematoma. Methods and materials Only patients with a surgical acute epidural hematoma or subacute/chronic subdural hematoma were considered. Other exclusion criteria were concurrent intraparenchymal pathology, bilateral pathology, or incomplete follow-up imaging. Between fall 2012 and spring 2015, 22 patients were included in the study. CT head imaging (preoperative, postoperative, and at ∼1- to 2-month clinic visit) were loaded into OsiriX (Pixmeo, Switzerland). All the intracranial regions were selected and all extra-axial features were removed; subsequently, software was used to calculate a global CT HU value. Results A repeated-measures ANOVA found significant time effect, p < 0.01, with significance between preoperative versus postoperative CT ( p = 0.03) and preoperative versus clinic visit CT ( p < 0.01). Conclusion The results from this study suggest that extra-axial hematomas, which deform the brain, can cause an elevation in global CT HU value; moreover, surgical decompression is associated with lower global CT HU values. The use of global CT HU values in selected populations may serve as an adjunct for the evaluation of surgical lesions.
Tavagnascoite, Bi4O4(SO4)(OH)2, a new oxyhydroxy bismuth sulfate related to klebelsbergite
Authors: Bindi Luca , Biagioni Cristian , Martini Bruno , Salvetti Adrio , Fontana Giovanni Dalla , Taronna Massimo , Ciriotti Marco E. 
Published: July 2016

AbstractThe new mineral tavagnascoite, Bi4O4 (SO4)(OH)2, was discovered in the Pb-Bi-Zn-As-Fe-Cu ore district of Tavagnasco, Turin, Piedmont, Italy. It occurs as blocky, colourless crystals, up to 40 μm in size, with a silky lustre. In the specimen studied, tavagnascoite is associated with other uncharacterized secondary Bi-minerals originating from the alteration of a bismuthinite ± Bi-sulfosalt assemblage. Electron microprobe analyses gave (average of three spot analyses, wt.%) Bi2O3 85.32, Sb2O3 0.58, PbO 2.18, SO3 8.46, H2Ocalc 1.77, sum 98.31. On the basis of 10 O apfu, the chemical formula is (Bi3.74Pb0.10Sb0.04)∑ = 3.88O3.68 (SO4)1.08(OH)2, with rounding errors. Main calculated diffraction lines are [d in Å (relative intensity) hkl] 6.39 (29) 012, 4.95 (19) 111,4.019(32)121,3.604(28)014 and 3.213(100)123. Unit-cell parameters are a = 5.831(1), b = 11.925(2), c = 15.123(1) Å, V = 1051.6(3) Å3, Z = 4, space group Pca21. The crystal structure was solved and refined from single-crystal X-ray diffraction data to R1 = 0.037 on the basis of 1269 observed reflections. It consists of Bi–O polyhedra and SO4 tetrahedra. Bismuth polyhedra are connected each to other to form Bi–O sheets parallel to (001). Successive sheets are linked together by SO4 groups and hydrogen bonds. Tavagnascoite is the Bi-analogue of klebelsbergite, Sb4O4(SO4)(OH)2, and it is the fifth natural known bismuth sulfate without additional cations. The mineral and its name have been approved by the IMA CNMNC (2014-099).
Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia
Authors: Kapralova Katarina , Horvathova Monika , Pecquet Christian , Fialova Kucerova Jana , Pospisilova Dagmar , Leroy Emilie , Kralova Barbora , Milosevic Feenstra Jelena D. , Schischlik Fiorella , Kralovics Robert , Constantinescu Stefan N. , Divoky Vladimir 
Published: July 2016

Key Points
Cells expressing JAK2 E846D or R1063H exhibit pathologic STAT5 activation in the specific context of EPOR. Cooperation of germ line JAK2 mutations E846D and R1063H defines a JAK2-signaling threshold for induction of erythrocytosis.
Impact of ICT-mediated collective awareness on urban mobility
Authors: Zia Kashif , Ferscha Alois , Din Ahmad , Shahzad Khurram , Majeed Awais 
Published: July 2016

Abstract

Purpose
This paper studies the influence of information and communication technologies on human reasoning and decision making. It investigates the potential impact of ambient intelligence on change in pedestrian mobility behavior, using a large city-scale scenario.

Methods
This work establishes an interplay between social and technological aspects of awareness by augmenting a model-driven framework of a realistic information eco-system. A distributed multi-agent system is developed to model a real-life urban mobility environment. The model is then simulated using a large scale parallel computing platform.

Results
Evaluation results revealed that the quality of information in ambient-assisted environments increases when compared with those without ambient intelligence.

Conclusion
We conclude that there is a positive correlation between the extent of information being shared in a socially-inspired information eco-systems and the level of collective awareness in an urban mobility scenario.