bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cytopathologic features of clear cell papillary renal cell carcinoma: A recently described variant to be considered in the differential diagnosis of clear cell renal epithelial neoplasms
Authors: Sayeed Sadia , Lindsey Kathryn G. , Baras Alexander S. , Jackson Christopher , Powers Celeste N. , Uram‐Tuculescu Cora , Smith Steven C. 
Published: April 2016

BACKGROUNDClear cell papillary renal cell carcinoma (CCPRCC) is a distinctive variant of renal cell carcinoma that has been formally adopted by the new Word Health Organization classification. An emerging consensus has documented its particularly indolent course and emphasized its separation from conventional clear cell renal cell carcinoma (CCRCC) for treatment planning. CCPRCC features in cytologic preparations have not been studied.METHODSThis study retrospectively identified a series of CCPRCCs that had cytology samples before the histopathologic diagnosis and reviewed corresponding cytologic materials, including aspirate smears, cell block materials, touch preparations, and core biopsy samples. The identified clinicopathologic and cytologic features were tabulated.RESULTSFive cases of CCPRCC with cytopathologic materials were identified from 4 women and 1 man aged 34 to 70 years (2 with end‐stage renal disease), and the sampled lesions were 1.8 to 11.0 cm. The original cytopathologic diagnostic considerations ranged from atypical cyst‐lining cells to angiomyolipoma to CCRCC and CCPRCC. The aspirate and touch preparation samples showed scant cellularity with scattered sheets and clusters of small, bland epithelial cells (much smaller than admixed renal tubular cells) with optically clear cytoplasm (lacking conspicuous cytoplasmic vacuolization) and small, grade 1 nuclei. The cell block materials and the core biopsy samples showed cyst walls with prominent myomatous stroma lined by low‐grade epithelium with optically clear cytoplasm, inverse nuclear polarization, and a characteristic cytokeratin 7–positive/carbonic anhydrase IX–positive phenotype. Three cases were treated with resection, 1 case was treated with ablation, and 1 case was under surveillance.CONCLUSIONSCCPRCC demonstrates recognizable cytomorphologic features and merits consideration in the cytologic differential diagnosis for kidney lesions. With increasing experience, more conservative management may be contemplated. Cancer Cytopathol 2016;124:565‐72. © 2016 American Cancer Society.
Efficient solvers for coupled models in respiratory mechanics
Authors: Verdugo Francesc , Roth Christian J. , Yoshihara Lena , Wall Wolfgang A. 
Published: April 2016

SummaryWe present efficient preconditioners for one of the most physiologically relevant pulmonary models currently available. Our underlying motivation is to enable the efficient simulation of such a lung model on high‐performance computing platforms in order to assess mechanical ventilation strategies and contributing to design more protective patient‐specific ventilation treatments. The system of linear equations to be solved using the proposed preconditioners is essentially the monolithic system arising in fluid–structure interaction (FSI) extended by additional algebraic constraints. The introduction of these constraints leads to a saddle point problem that cannot be solved with usual FSI preconditioners available in the literature. The key ingredient in this work is to use the idea of the semi‐implicit method for pressure‐linked equations (SIMPLE) for getting rid of the saddle point structure, resulting in a standard FSI problem that can be treated with available techniques. The numerical examples show that the resulting preconditioners approach the optimal performance of multigrid methods, even though the lung model is a complex multiphysics problem. Moreover, the preconditioners are robust enough to deal with physiologically relevant simulations involving complex real‐world patient‐specific lung geometries. The same approach is applicable to other challenging biomedical applications where coupling between flow and tissue deformations is modeled with additional algebraic constraints. Copyright © 2016 John Wiley & Sons, Ltd.
Fabrication of a Stable and Efficient Antibacterial Nanocoating of Zn‐CuO on Contact Lenses
Authors: Tuby Reut , Gutfreund Shay , Perelshtein Ilana , Mircus Gabriel , Ehrenberg Miriam , Mimouni Michael , Gedanken Aharon , Bahar Irit 
Published: April 2016

AbstractThe problem of bacterial infections in general, and in medical devices in particular, has led to extensive research to produce antibacterial coatings. The current research presents a unique technique for imparting antibacterial properties to contact lenses. The coating consists of nanoparticles of zinc‐doped copper oxide. In the coating process, active nanoparticles are formed and immediately deposited onto the surface of the contact lens. The coating thus formed is homogeneous and stable, without leaching of the nanoparticles. The antibacterial activity was evaluated against Gram‐positive and Gram‐negative bacteria. The optimization of the coating process has led to a smaller particle size and good antibacterial activity.
Low‐Permeability Poly(ether Ether Ketone)‐Based Ampholytic Membranes
Authors: Narducci Riccardo , Pasquini Luca , Chailan Jean‐François , Knauth Philippe , Di Vona Maria Luisa 
Published: April 2016

AbstractIon‐exchange membranes based on sulfonated and sulfaminated poly(ether ether ketone) were prepared by a modified sulfamination route. In a first step, poly(ether ether ketone) was sulfonated. The sulfonic acid groups were then transformed into chlorosulfonic moieties by reaction with thionyl chloride. A proportion of the chlorosulfonic functionalities reacted with dimethylamine to give basic sulfonamide groups, whereas those remaining were hydrolyzed back to sulfonate moieties obtaining, after immersion in acidic solution, an ampholytic polymer. The thermal, mechanical, electrical, and permeability properties of these amphoteric membranes were characterized. These membranes exhibit good thermal and mechanical stability and ultra‐low vanadium ion permeability. The type and value of ion conductivity can be adjusted by the choice of acidic or basic medium. The tunable ion conductivity and the low ion permeability are suitable characteristics for the development of high‐performance separator membranes.
Synthesis, Characterization, and Luminescence Modulation of a Metal–Organic Framework Based on a Cyclotriphosphazene‐Functionalized Multicarboxylate Ligand
Authors: Ling Yajing , Liu Huiming , Jiao Jingjing , Feng Yunlong , He Yabing 
Published: April 2016

AbstractBy using a multicarboxylate ligand consisting of six peripheral 1,3‐benzenedicarboxylalte units connected to the central cyclotriphosphazene ring through a P−O−C spacer, a novel metal–organic framework, [Cd5L(H2O)4]⋅2 (CH3)2NH2⋅6 DMF (L=hexakis(3,5‐dicarboxylatephenyloxy)cyclotriphosphazene), was solvothermally synthesized and characterized by single‐crystal and powder XRD, thermal gravimetric analysis, and IR and photoluminescence spectroscopy. Single‐crystal XRD analyses show that the framework is an anionic 3D network assembled from pentanuclear [Cd5(COO)10] secondary building units and organic linkers. TOPOS software analyses indicate that two alternative simplifications based on the organic linkers can produce five‐connected uninodal bnn‐type topology or novel (2,3,6,10)‐connected five‐nodal topology. Additionally, it is interesting that the luminescence intensity of the complex can be modulated by postsynthetic ion exchange. This study highlights that cyclotriphosphazene‐functionalized multicarboxylates, with the combined advantages of conformation diversity and easy functionalization, are a promising type of organic ligand for the synthesis of metal–organic frameworks with fascinating structures and interesting properties.
Shift in precipitation regime promotes interspecific hybridization of introduced Coffea species
Authors: Gomez Céline , Despinoy Marc , Hamon Serge , Hamon Perla , Salmon Danyela , Akaffou Doffou Sélastique , Legnate Hyacinthe , de Kochko Alexandre , Mangeas Morgan , Poncet Valérie 
Published: April 2016

AbstractThe frequency of plant species introductions has increased in a highly connected world, modifying species distribution patterns to include areas outside their natural ranges. These introductions provide the opportunity to gain new insight into the importance of flowering phenology as a component of adaptation to a new environment. Three Coffea species, C. arabica, C. canephora (Robusta), and C. liberica, native to intertropical Africa have been introduced to New Caledonia. On this archipelago, a secondary contact zone has been characterized where these species coexist, persist, and hybridize spontaneously. We investigated the impact of environmental changes undergone by each species following its introduction in New Caledonia on flowering phenology and overcoming reproductive barriers between sister species. We developed species distribution models and compared both environmental envelopes and climatic niches between native and introduced hybrid zones. Flowering phenology was monitored in a population in the hybrid zone along with temperature and precipitation sequences recorded at a nearby weather station. The extent and nature of hybridization events were characterized using chloroplast and nuclear microsatellite markers. The three Coffea species encountered weak environmental suitability compared to their native ranges when introduced to New Caledonia, especially C. arabica and C. canephora. The niche of the New Caledonia hybrid zone was significantly different from all three species' native niches based on identity tests (I Similarity and D Schoener's Similarity Indexes). This area appeared to exhibit intermediate conditions between the native conditions of the three species for temperature‐related variables and divergent conditions for precipitation‐related ones. Flowering pattern in these Coffea species was shown to have a strong genetic component that determined the time between the triggering rain and anthesis (flower opening), specific to each species. However, a precipitation regime different from those in Africa was directly involved in generating partial flowering overlap between species and thus in allowing hybridization and interspecific gene flow. Interspecific hybrids accounted for 4% of the mature individuals in the sympatric population and occurred between each pair of species with various level of introgression. Adaptation to new environmental conditions following introduction of Coffea species to New Caledonia has resulted in a secondary contact between three related species, which would not have happened in their native ranges, leading to hybridization and gene flow.
MALDI‐SpiralTOF technology for assessment of triacylglycerols in Croatian olive oils
Authors: Peršurić Željka , Osuga Junichi , Galinac Grbac Tihana , Peter‐Katalinić Jasna , Kraljević Pavelić Sandra 
Published: April 2016

Traceability and authenticity of olive oils in Croatia were probed by a versatile analytical approach using spiral MALDI‐TOF MS system for the triacylglycerol (TAG) analysis. Molecular ion patterns were shown to represent specific data for statistical analysis, in which differences of cultivar regions of Croatian coast were recognized. This pilot project allows indications to be followed in high throughput procedures with high number of samples to get statistically relevant data for discrimination of olive oils from different geographic sites. Additionally, the fragmentation in the TOF/TOF MS provided distinct highly valuable data for assignment of acyl residues. In this way molecular species with different fatty acid substituents can be clearly assigned and possible isomeric mixtures identified.Practical applications: Olive oil TAG analysis is important to determine authenticity of olive oil and detect adulteration. This work shows that spiral MALDI‐TOF MS analysis of TAG composition is a promising method for tracing geographical differences in olive oils.Triacylglycerol composition of Croatian extra virgin olive oils was determined by spiral MALDI‐TOF MS technology. Obtained data were analyzed by Principal Components Analysis to establish relations between TAG composition and geographical origin and proved useful for assessment of Croatian olive oil origin.
Preparation of Cocrystals of 1,4‐Diimidazolylbutadiene with a Template Molecule and Dependence of the Cocrystal Photochemical Products on Wavelength
Authors: Meng Fanxing , Min Jing , Wang Chunyu , Wang Liyan 
Published: April 2016

AbstractA cocrystal of (1E,3E)‐1,4‐di(1H‐imidazol‐1‐yl)buta‐1,3‐diene (DIBD) with 5‐methoxyresorcinol, a DIBD crystal and a DIBD monohydrate crystal were prepared and characterized by single‐crystal X‐ray analysis. The cocrystal satisfies Schmidt's topochemical postulate for photodimerization, whereas the other two crystals do not. The DIBD in the cocrystal was irradiated with 313.5 nm light to produce a dimer (a divinylcyclobutane derivative) in high yield through a [2+2] cycloaddition reaction. This dimer then underwent a Cope rearrangement by heating to produce a second dimer, a cyclooctadiene derivative. This second dimer can also be obtained by irradiating the cocrystal with a broadband Hg lamp without an optical filter. It was found that 257 nm light is critical for formation of the second dimer. The dependence of the photochemical products on wavelength may originate from the characteristic UV absorption.
Palladium‐Catalyzed Amination of C‐5 Bromoimidazo[2,1‐b]­[1,3,4]­thiadiazoles
Authors: Copin Chloé , Buron Frédéric , Routier Sylvain 
Published: April 2016

AbstractA new and efficient palladium‐catalyzed amination of imidazo[2,1‐b][1,3,4]thiadiazole at the C‐5 position under microwave irradiation is reported. The reactivity toward bromine release at the C‐5 position was investigated, and palladium‐catalyzed cross‐coupling conditions were optimized. A wide range of amines was employed to examine the scope and limitations of the method. To complete this methodological study, the influence of the nature and the positions of additional imidazo[2,1‐b][1,3,4]thiadiazole substitutions was investigated.
Analgesic effects of navigated motor cortex rTMS in patients with chronic neuropathic pain
Authors: Ayache S.S. , Ahdab R. , Chalah M.A. , Farhat W.H. , Mylius V. , Goujon C. , Sorel M. , Lefaucheur J.‐P. 
Published: April 2016

AbstractBackgroundRepetitive transcranial magnetic stimulation (rTMS) can relieve neuropathic pain when applied at high frequency (HF: 5–20 Hz) over the primary motor cortex (M1), contralateral to pain side. In most studies, rTMS is delivered over the hand motor hot spot (hMHS), whatever pain location. Navigation systems have been developed to guide rTMS targeting, but their value to improve rTMS efficacy remains to be demonstrated.ObjectiveTo compare the analgesic efficacy of HF‐rTMS targeting the hMHS (non‐navigated procedure) or the M1 representation of the pain region (navigated procedure).MethodsThe analgesic effect of a single session of 10 Hz‐rTMS of M1 was assessed in 66 patients with neuropathic pain of various causes and locations, according to three conditions: sham or active non‐navigated rTMS of the hMHS and active navigated rTMS of the pain region.ResultsPain was relieved by both active rTMS conditions, and not by sham. Pain location influenced the results: upper or lower limb pain was significantly relieved, but not facial or hemibody pain. Pain relief lasted 1 week only after navigated rTMS, compared to sham.ConclusionNavigation may improve HF‐rTMS efficacy in patients with limb pain, whereas targeting remains to be optimized for more diffuse or facial pain.What does this study add?To produce analgesic effects, HF‐rTMS should be applied over the precentral cortex contralaterally to the painful side. Although the hMHS is the target normally chosen for stimulation, the optimal target has not been defined yet. Neuronavigational methods have been recently developed; they allow the integration of MRI data and are thought to improve rTMS efficacy.
Shale Gas: A Review of the Economic, Environmental, and Social Sustainability
Authors: Cooper Jasmin , Stamford Laurence , Azapagic Adisa 
Published: April 2016

AbstractThe growth of the shale gas industry in the US has raised expectations that other nations could boost domestic gas production, leading to lower energy prices and improved energy security. However, the degree to which the US experience is transferable to other countries is uncertain. Furthermore, sustainability implications of shale gas development remain largely unknown. In an attempt to find out if and how shale gas could be exploited in a sustainable way, this paper reviews the economic, environmental, and social aspects of shale gas. These include costs, energy security, employment, water and land pollution, greenhouse gas emissions, earthquakes, and public perception. The literature suggests that it is possible to develop shale gas in a sustainable way, but its future will depend on the industry being able to address the environmental concerns, the political will to see the industry through to maturity, and public support, with the latter most likely being the biggest determinant.
3D Interconnected Porous Graphene Sheets Loaded with Cobalt Oxide Nanoparticles for Lithium‐Ion Battery Anodes
Authors: Puthusseri Dhanya , Aravindan Vanchiappan , Madhavi Srinivasan , Ogale Satishchandra 
Published: April 2016

AbstractNanomaterials with high surface‐to‐volume ratio and tunable electronic and optical properties have expanded their use in variety of applications, especially energy conversion and storage. Here we report on the synthesis of a cobalt oxide (Co3O4)/3D‐interconnected porous graphene (PG) nanocomposite by using a simple solvothermal route and its application as a Li‐ion battery anode. Among the different compositions investigated, the composite PG‐600 (with 50 % PG) showed a discharge capacity of 700 mAh g−1 at a current density of 500 mA g−1 and maintained 90 % retention after 80 cycles. The high surface area of the 3D PG sheets helps the Co3O4 nanoparticles to form a uniform dispersion on the surfaces. The increased surface area (accessibility) and electrical conductivity of the composite result in significant enhancement in the capacity, cycling stability, and rate capability than the native Co3O4 phase.
A Narrative Review of Outcome Studies for Residential and Partial Hospital‐based Treatment of Eating Disorders
Authors: Friedman Keren , Ramirez Ana L. , Murray Stuart B. , Anderson Leslie K. , Cusack Anne , Boutelle Kerri N. , Kaye Walter H. 
Published: April 2016

AbstractObjectiveThe objective of this study was to review the current eating disorders outcome literature after residential or partial hospitalization programme (PHP) treatment.MethodArticles were identified through a systematic search of PubMed and PsycINFO.ResultsTwenty‐two PHP and six residential treatment studies reported response at discharge and tended to find improvement. Fewer studies (nine PHP and three residential) reported outcome at some interval after discharge from treatment. These tended to find sustained improvement. A substantial proportion of patients were lost to follow‐up, particularly for residential treatment. Only two follow‐up studies used controlled trials; both showed efficacy for PHP compared with inpatient treatment with regard to maintaining symptom remission.ConclusionsImprovement at discharge may not predict long‐term outcome. Long‐term follow‐up studies were confounded by high dropout rates. While higher levels of care may be essential for reversing malnutrition, there remains a lack of controlled trials showing long‐term efficacy, particularly for residential treatment settings. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
Parent and conjugated estrogens and progestagens in surface water of the Santa Ana River: Determination, occurrence, and risk assessment
Authors: Ma Li , Yates Scott R. , Ashworth Daniel 
Published: April 2016

Abstract

The present study investigated the occurrence of 13 parent and conjugated estrogens and progestagens in surface water of the Santa Ana River. With the exception of the synthetic hormones 17α-ethynylestradiol and mestranol, other compounds were detected at least twice at 10 representative sites, with the ubiquitous estrone (E1) and 17β-estradiol-3-sulfate as the dominant compounds quantified (0.24–6.37 ng/L and 0.49–9.25 ng/L, respectively). Sites near dairy farms exhibited high levels of conjugates, whereas those close to a sewage treatment plant (STP) effluent outlet displayed relatively high concentrations of E1. Principle component analysis coupled with multiple linear regression revealed dairy farms and the STP as the 2 significant contamination sources, accounting for 69.9% and 31.1% of the total hormone burden, respectively. Risk assessment results suggested E1 and 17β-estradiol (E2) as the 2 hormones with the largest risks to aquatic organisms, and which combined, contributed &gt;90% of the total estrogenicity. Most of the sites investigated showed that E1 and E2 posed a medium risk (0.1 &lt; risk quotient &lt; 1), whereas each induced a high risk (risk quotient &gt;1) at sites severely impacted by the STP and dairy farms. These results suggest that river health would benefit from effective treatment of waste at the STP and dairy farms prior to discharge. Environ Toxicol Chem 2016;35:2657–2664. © 2016 SETAC
The evaluation of 3 diets for rearing Hyalella azteca and the influence of diet on acute ammonia toxicity
Authors: Kennedy Lisa M. , Watson-Leung Trudy L. , Poirier David G. 
Published: April 2016

Abstract

Three Hyalella azteca cultures were reared on different diets since birth, reflecting the recommended diets of various investigators. The 3 diets consisted of fish flakes (FF), a mixture of fish flakes supplemented with the diatom Thalassiosira weissflogii (FF-D), and a mixture of fish flakes supplemented with yeast, cereal grass media, and trout chow (FF-YCT). The 3 diets were evaluated by comparing 20 wk of culturing data, along with the organism's response to standard 96-h toxicity testing with ammonium chloride over a range of pH and temperature. Hyalella azteca fed the FF-D diet had the highest overall survival rate (96.6%, standard deviation [SD] 4.3%) compared to those fed the FF diet (92.0%, SD 12.7%), or the FF-YCT diet (91.1%, SD 14.8%), although difference in survival was not statistically significant. Organisms fed the FF-D diet produced a higher number of young per week per adult (6.1, SD 2.8) than the FF diet (5.1, SD 2.2), or the FF-YCT diet (4.0, SD 1.2), although differences were not statistically significant. Of the diets evaluated, H. azteca reared on the FF-D diet were often significantly more resistant to total and un-ionized ammonia toxicity in acute 96-h testing than those reared on the other 2 diets across the 2 temperatures and 5 pHs tested, suggesting this may be the most optimal diet for this species. Environ Toxicol Chem 2016;35:2416–2424. © 2016 SETAC