bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les Indo-Européens, des ancêtres encombrants ?
Authors: Demoule Jean-Paul 
Published: October 2024

La reconnaissance d’une parenté entre les langues de la plupart des régions de l’Europe et d’une partie de l’Asie occidentale s’est peu à peu imposée et a donc défini la famille des langues dites indo-européennes, plus proches les unes des autres qu’elles ne le sont d’autres familles de langues, sémitiques, sino-tibétaines ou autres. L’interprétation de cette parenté indiscutable s’est inspirée du cas des langues romanes, toutes plus ou moins descendantes du latin à la suite de la conquête romaine d’une partie de l’Europe. On a donc cherché d’où aurait pu partir ce peuple préhistorique conquérant, dont la langue originelle reconstruite aurait donné naissance à toutes celles d’aujourd’hui. Parmi d’innombrables hypothèses, trois surnagent. La première est le pourtour de la Baltique ; sans aucun argument archéologique, elle a été soutenue en son temps par le nazisme et reprise par certaines extrêmes droites actuelles. La deuxième est le Proche-Orient et s’identifierait avec la diffusion de l’agriculture sédentaire (le néolithique) à partir de cette région. La troisième, actuellement majoritaire, verrait des guerriers cavaliers issus des steppes de la mer Noire se répandre ensuite dans toute l’Europe et aux alentours. Malgré le secours récent, popularisé à grand bruit, de la génétique, cette dernière ne saurait se réduire aux formes simplistes qu’on lui a données. C’est pourquoi ce sont des modèles beaucoup plus complexes, aussi bien sur le plan linguistique (au-delà d’un simple arbre généalogique) que sur le plan historique et anthropologique (au-delà d’un modèle invasionniste et colonial), quant à la formation et à la diffusion de ces langues, qui mériteraient d’être désormais développés.
La reconnaissance du génocide des Arméniens : un itinéraire politique inachevé
Authors: Marian Michel 
Published: October 2024

La mise en mémoire du génocide des Arméniens a connu, globalement et en France, un cheminement générationnel et psychologique commun à celui des grands traumatismes collectifs. La reconstruction des personnes et la réception du récit collectif ont pourtant suivi une voie particulière. Le combat mené par le régime républicain de la Turquie contre la résurgence de cette mémoire a produit une scène mémorielle à trois acteurs ( plaignant, accusé et juge), distincte du modèle du travail intérieur sur la Shoah ou de l’interpellation postcoloniale. Mais, du fait du refus et de l’éloignement, il ne pouvait se construire un droit positif de ce crime. Le besoin d’une solution a fait apparaître un « droit à la mémoire », où la vérité est due aux victimes, à défaut d’une justice. C’est cette logique, formulée en France dès les années 1980, qui s’est développée jusqu’à 2019 et la décision française d’une journée annuelle de commémoration du génocide des Arméniens ou 2021 et la reconnaissance du génocide par Joe Biden. Elle a aussi facilité pour les Arméniens de France la construction d’une communauté loyale à la République et fidèle à son histoire. Elle est pourtant insuffisante devant une négation qui persiste, bloque le devenir démocratique de la Turquie, se propage de celle-ci à l’Azerbaïdjan et tend les relations entre ces pays et ceux qui ont accueilli la diaspora arménienne.
The diagnostic and prognostic significance of L1 cell adhesion molecule, Sperm-associated antigen 9 and P53 expression in endometrial lesions (immunohistochemical study)
Authors: Elshawarby Zeinab I. , Saad Eman A. , Eleleimy Hiam A. , Aboelkheir Mona A. 
Published: October 2024

Background
Endometrial carcinoma is the most common invasive neoplasm of the female reproductive tract. L1 cell adhesion molecule (L1CAM), Sperm-associated antigen 9 (SPAG9), and P53 have a role in the process of tumorigenesis and progression of several human malignant tumors, however, the role of them in cancer of endometrium is still not clear.

Aim
The study was performed to evaluate L1CAM, SPAG9, and P53 expression about different clinicopathological parameters in endometrial endometrioid adenocarcinoma.

Methods
The immunohistochemical study was performed on 50 cases of endometrial lesions including endometrial hyperplasia without atypia (10 cases), endometrial hyperplasia with atypia (10 cases), and endometrial endometrioid carcinoma (30 cases). Immunohistochemical staining techniques were used to evaluate the role of L1CAM, P53, and SPAG9 in endometrial endometrioid adenocarcinoma (EEC) and their relation to different clinicopathological data and patient’s survival followed for 36 months.

Results
This study declared that both L1CAM and SPAG9 were found to be upregulated in EEC. Their over-expression was related to adverse clinicopathological parameters including high tumor grade, deep myometrial invasion, lymphovascular Invasion (LVI), and advanced tumor stage, while there was no significant relation between their expression and tumor size, cervical affection, and lymph node involvement. A high statistically significant link between L1CAM expression and poor patient survival was detected. Mutant type P53 was significantly related to adverse clinicopathological data as high tumor grade, deep myometrial invasion, lymphovascular space invasion (LVSI), and high tumor stage. There was a positive significant relation between mutant type P53 and high SPAG9.

Conclusions
The early identification of EEC in asymptomatic high-risk women may benefit from L1CAM and SPAG9 testing in combination with P53 protein. Also, they could be viewed as separate predictive variables in the EEC and might play a crucial part in the EEC’s chemoresistance.
Circulating cell-free long noncoding RNA H19 as a promising novel biomarker in colorectal cancer patients from Egypt
Authors: Ahmed Sanaa S. , Gomaa Salwa H. , Selimah Mohamed , Elsherif Amr , Rashad Radwa M. , Osman Eman M. 
Published: October 2024

Background
Colorectal cancer (CRC) has emerged as a significant health issue affecting millions worldwide. The current study aimed to evaluate circulating H19 expression levels as a noninvasive CRC biomarker and its relationship to tissue expression of β catenin as one of the most oncogenic pathways involved in CRC.

Patients and methods
Thirty patients were enrolled in the current study, all diagnosed with operable CRC. Another group of 30 healthy age-matched and sex-matched individuals were enrolled in this study as a control group. H19 expression levels were measured in plasma samples from 30 CRC patients before and 14 days after surgery and in 30 plasma samples from healthy controls using quantitative real-time PCR. In addition, tissue expression of β catenin was determined using the immunohistochemistry technique.

Results
Preoperative H19 expression in plasma was signfcantly upregulated in comparison to controls and a significant decline occurred postoperatively. All CRC cases showed positive β catenin expression. Furthermore, H19 correlated positively with β catenin score. Receiver-operator curve analysis revealed the high diagnostic significance of plasma H19 to discriminate CRC patients from control, which improved when combined with serum carcinoembryonic antigen and carbohydrate antigen 19-9. Moreover, H19 expression correlated positively with tumor-node-metastasis staging of the disease.

Conclusions
Our findings suggest the oncogenic role of H19 in CRC and identify its expression level in plasma as a promising biomarker that could be very helpful in early diagnosis of CRC and could also help in CRC prognosis.
An Observational Study of Electrolytes and Other Metabolic Parameters in Patients with Delirium in Hospital Settings
Authors: Kumar Sunil , Bhattacharyya Debajyoti , Singh Bijender , Khanna Puneet , Qureshi Mohd Ishaque 
Published: October 2024

Abstract

Background:
Despite extensive research, pathophysiology of delirium remains inadequately understood, with studies suggesting a role for inflammatory mediators, cholinergic deficiency, and metabolic disturbances.

Aim:
This study aims to explore the association of electrolytes and other metabolic parameters in hospitalized delirium patients as compared to age- and gender-matched nondelirious controls.

Materials and Methods:
The observational case–control study was conducted at a multispecialty hospital in eastern India where 100 inpatients diagnosed with delirium (cases) and an equal number of age- and gender-matched nondelirious inpatients (controls) were administered a semi-structured pro forma for sociodemographic variables and assessed for electrolytes and other metabolic parameters. Statistical analysis employed Pearson’s Chi-square test to assess the significance of differences between the two groups.

Results:
The study revealed statistically significant differences in metabolic disturbances in delirium cases as compared to controls with a greater association of hyperglycemia (P = 0.009), hyponatremia (P = 0.002), hypercalcemia (P = 0.001), hyperkalemia (P = 0.030), and hypokalemia (P = 0.005) among delirium patients. Hypoalbuminemia (P = 0.002) and elevated bilirubin levels (P = 0.014) as well as uremia (P < 0.001) and elevated creatinine levels (P < 0.001) also had a greater association with delirium cases than controls. Sociodemographic analysis revealed a higher incidence of delirium in older adults and males.

Conclusion:
There was a significant association between delirium and various biochemical disturbances, highlighting the importance of thorough metabolic workup to identify and correct these disturbances which would potentially enhance delirium outcomes. There is a need for further studies to explore the causal pathways of these associations and the impact of targeted metabolic interventions on delirium outcomes.
Descifrando la inclusión digital: exploración de su relación con la alfabetización digital y otras variables conexas
Authors: Buch Gómez Ingrid Lucrecia 
Published: October 2024

PROBLEMA: en la era digital actual, la alfabetización digital es clave para la participación en la sociedad y la educación, por lo que en este estudio se explora cómo la alfabetización digital y variables afines, se relacionan con la inclusión digital. OBJETIVO: establecer la relación entre la alfabetización digital y otras variables conexas con la inclusión digital de un grupo de estudiantes a nivel de maestría. MÉTODO: se desarrolló en el marco del paradigma pospositivista y enfoque cuantitativo, empleándose el diseño correlacional, de alcance transversal no experimental. Como instrumento se usó una encuesta aplicada a través de un cuestionario en línea. La muestra consistió en 35 estudiantes universitarios seleccionados mediante un muestreo no probabilístico voluntario. RESULTADOS: en el modelo final resultaron ser significativas a un alfa de 5% las variables: número de capacitaciones sobre TIC (finalizadas) de menos de cuarenta horas, conocimiento de delitos informáticos, conocimiento de protocolos de seguridad y alfabetización digital, con un coeficiente de correlación de R=0.843, R2=0.711 y R2-ajustado=0.673. En promedio el índice de inclusión digital fue de 0.46, con 0.48 para mujeres y 0.45 para hombres, para el índice de alfabetización digital, 0.45, descendiendo ligeramente a 0.44 en mujeres y manteniéndose en 0.45 en hombres, respecto a la competencia digital fue de 0.41, con 0.40 para el uso y 0.43 para el conocimiento. CONCLUSIÓN: la alfabetización digital está directamente relacionada con la inclusión digital; su coeficiente β4=0.152 resultó ser significativa al 5%, lo que indica que un cambio en una unidad de alfabetización digital produce un cambio proporcional de 0.152 unidades en la Inclusión Digital, lo que sugiere que a un mayor nivel de alfabetización digital entre los estudiantes se relaciona positivamente con un mayor nivel de inclusión digital
Currículum oficial del programa Técnicos en Urgencias Médicas (TUM) y la preparación socioemocional del bombero
Authors: Urrutia Lorenti Ludvin Ricardo 
Published: October 2024

OBJETIVO: analizar cómo el currículum oficial del programa TUM prepara socioemocionalmente al bombero para enfrentar el estrés postraumático. MÉTODO: la metodología utilizada presenta un enfoque cualitativo, un diseño fenomenológico y un alcance exploratorio. La muestra estuvo conformada por 15 personas. RESULTADOS: los resultados revelan que no se cuenta con una malla o red curricular que presente los contenidos procedimentales, declarativos y actitudinales que refuercen la formación socioemocional del participante del programa. Los valores del programa TUM no contempla la formación en cuidado socioemocional en los estudiantes. No se encontró evidencia de formación de instructores, relacionados con el cuidado socioemocional de los bomberos. CONCLUSIÓN: a partir de los hallazgos se arriban a la conclusión de que se necesita establecer un pensum de estudios que contengan contenidos declarativos, procedimentales y actitudinales orientados al autocuidado emocional y se debe construir un diseño curricular que contenga perfiles de ingreso y egreso cimentados en las competencias y contenidos que sugieren los expertos en la temática del autocuidado socioemocional de los bomberos voluntarios.
Traveling Dalam Al-Qur’an: Studi Penafsiran Ayat-ayat Riḥlah dan Safar dalam Tafsir Al-Azhar
Authors: Najib Jauhar , Sulthoni Akhmad , Mukharom Ridho Muhammad 
Published: October 2024

In this world, living beings, particularly humans, are constantly driven to move and travel, aiming to achieve better outcomes both in this life and the hereafter. This movement can be seen as an effort to meet various human needs, as explained by Abraham Maslow in his hierarchy of needs, which ranges from basic physiological needs to higher levels of self-actualization. People embark on journeys to secure sustenance, fulfill religious duties such as studying, performing Hajj and Umrah, visiting friends to strengthen bonds, assisting those in need, and visiting the sick. These activities not only satisfy physiological and safety needs but also foster social connections, esteem, and ultimately lead to self-actualization. The encouragement from Allah and His Messenger to travel the earth to witness the majesty of Allah's creation aligns with the pursuit of self-actualization as described by Maslow. This study seeks to explore the meanings of Riḥlah and Safar as interpreted in Tafsir Al-Azhar. The research utilizes the tafsir maudhu'i method, with Buya Hamka's Tafsir al-Azhar serving as the primary source, alongside other scholarly works. The methodology involves defining the theme, gathering relevant verses, and analyzing them with a focus on the selected source. The findings indicate that Riḥlah in the Qur'an, as interpreted by Buya Hamka, refers to traveling for trade or business, a common practice among Arabs, including the Prophet. Meanwhile, Safar is understood as a journey, often linked with the relief (rukhshoh) granted to travelers, illustrating how these travels fulfill various human needs as outlined by Maslow.
Makna Simbolik dalam Tradisi Adat Khatam Al-Qur’an Pada Acara Pernikahan Oleh Masyarakat Desa Sekernan Muaro Jambi
Authors: Aisi Nurmala Sari  
Published: October 2024

Every Muslim has various forms of interaction with the Qur'an. For example, the people of Sekernan Village make the recitation of khataman al-Qur'an part of the traditional wedding procession. In practice, this tradition has a unique procession that acculturates with local culture. Therefore, the community makes this tradition a religious ritual in the form of meaningful symbols that are believed to have a positive influence on the sustainability of building a household. So, this research aims to look at the procession and the meaning behind the practice. Using Clifford Geertz's theory, it is used as an analysis to find the meaning behind the symbols in the traditional tradition of khatam al-Qur'an. The results of this study show that there are several series of customs that must be carried out by the bride before reading the Qur'an. Among them are the procession of processions, weighing, then reading the khatam al-Qur'an starting from surah al-Duha to surah an-Nas accompanied by the Koran teacher and his parents. In addition, this tradition also has symbols that relate to the concept of religion, namely in the form of religious education, birrul walidain, and privileges that are believed to have ultimate meaning, so that it continues to be maintained to this day.
تحسين أداء العملي ة الإنتاجية باستخدام منهجية الستة سيجما حالة دراسية بالشركة الليبية للحدي د والصل ب
Authors: درميش أميرة , شنب عمر , الأمين فتحي , أبوقديدة رمضان 
Published: October 2024

لم يعد الالتزام بمواصفات المنتجات الصناعية كافيا في الوقت الحالي مع التنافس الكبير في الأسواق، ولقد أصبح من الضروري لتحقيق متطلبات العميل استخدام أساليب تحسين الجودة الأكثر تطوراً. تكمن مشكلة الدراسة في سعى الشركة الليبية للحديد والصلب للتحسين المستمر لمنتجاتها من ناحية الجودة ووقت التصنيع والانتظار، وكذلك خفض التكاليف وزيادة الإنتاجية لكسب ثقة المستهلك، ولتحقيق هذه المتطلبات، يجب عليها استخدام التقنيات الحديثة لقياس الجودة. وعليه فإن هذا البحث يهدف إلى دراسة إمكانية تطبيق منهجية الستة سيجما في الشركة الليبية للحديد والصلب، والتعرف على الفوائد الناتجة عن تطبيقها، والمعوقات التي ترافق عملية التطبيق. تمت دراسة الحالة بمصنع درفلة القضبان لمعرفة سير العملية الإنتاجية وكمية الإنتاج والكشف عن القطع المعيبة، ومعرفة أسباب حدوث المعيب، والخفض من هذه الأسباب وتحسين جودة المنتجات. وقد تم ذلك عن طريق تشكيل فريق لتحديد أهم الخواص الميكانيكية التي تم قياسها (إجهاد الخضوع، قوة الشد والاستطالة)، وتحديد عدد العينات، وحجمها، وقد تم جمع بيانات العينات من المعمل الخاص بمصنع الدرفلة وتحليلها بالبرنامج الإحصائيMinitab ورسم لوحات المتوسط والمدى وتحليل مقدرة العملية الإنتاجية، وحساب مستوى الستة سيجما عن طريق معادلة .DPMO ومن خلال هذه الدراسة تم التوصل إلى أن أغلب القطع المعيبة كان سببها انخفاض في إجهاد الخضوع بسبب انخفاض نسبة الكربون. وكذلك فإنه من الضروري تحسين عملية التبريد المائي والكشف الدوري عليها. وتوصلت الدراسة لضرورة تنفيذ برامج تدريبية لتأهيل العاملين وتدريبهم على تقنيات وأدوات الستة سيجما، وكذلك توفير جميع متطلبات التطبيق والنجاح لمنهجية الستة سيجما.
Hunting resources as an object of legal regulation
Authors: Chekhovskikh I. A. , Ol E. M. 
Published: October 2024

Hunting resources are a special object of legal regulation, in relation to which a specific regime for their protection and use can be established. The current legislation provides for differentiation of requirements in relation to hunting resources, in relation to which a prohibition or permit regime is introduced.The article provides the main examples of establishing appropriate permits or prohibitions related to the extraction of hunting resources, which accordingly form the legal regime for the use and protection of wildlife.
The effect of probiotics, prebiotics and synbiotics on the restoration of the clinical state and balance of the intestinal microbiome after antibiotic therapy
Authors: Katargin R. S. , Prusakov A. V. , Golodyaeva M. S. 
Published: October 2024

The aim of the study was to establish the degree of influence of probiotics, prebiotics and synbiotics on the restoration of the clinical condition and balance of the intestinal microbiome of animals after antibiotic therapy.We studied 20 cats of different ages who underwent antibacterial therapy using the drug Ceftriaxone at a dose of 20.0 mg per kg of body weight 2 times a day, in the form of intramuscular injections, divided into four groups, each of which included five animals.The animals of the first group were prescribed the probiotic "Subtilis". The latter was administered orally in a dose of 8 drops, for 14 days. Animals of the second group were prescribed the probiotic "Subtilis" at the same dose and with the same multiplicity, as well as the prebiotic "Vetelact" in addition to it, at the rate of 0.1 ml per 1.0 kg of body weight daily for 14 days. The animals of the third group were administered orally the synbiotic "Evitalia-Vet" 1 tablet for 14 days. The fourth group was a control group. The animals included in it were under observation and did not receive any drugs.It was found that the restoration of the clinical state and balance of the intestinal microbiome after antibiotic therapy was most intensive in animals receiving the probiotic "Subtilis" and the prebiotic "Vetelact". Under the influence of these drugs, at the end of treatment, the level of hemoglobin, erythrocytes and hematocrit decreased by 22.0%, 19.0% and 15.7%, respectively, in animals receiving them, compared with the indicators before it began. Also, in comparison with other groups, animals receiving the probiotic "Subtilis" and the prebiotic "Vetelact" showed a more pronounced decrease in the level of urea and total protein in blood serum, while the number of lactobacilli at the end of treatment was 42.0% higher, and the population of E. coli decreased by 37.0%, in comparison with control.Thus, the simultaneous administration of probiotics and prebiotics to animals after undergoing antibiotic therapy gives the most effective result, manifested in the accelerated restoration of their clinical condition and the balance of the intestinal microbiome.
Use of immunotropic drugs in wound processes in different species of animals
Authors: Stekolnikov A. A. , Reshetnyak V. V. , Burdeyny V. V. , Malakhova V. V. , Iskaliev E. A. , Elokhin M. D. 
Published: October 2024

In conditions of intensification of livestock farming, urbanization of society, accompanied by an increase in the number of productive and small domestic animals, changes in the conditions of their keeping, feeding, and exploitation, the number of non-communicable diseases is significantly increasing. Surgical diseases occupy a special place among them. In addition to accidental wounds, in some cases they are technologically widespread, especially in pig farming - castration, tail trimming, etc., accompanied by various kinds of complications.Classic measures of their treatment quite often do not give the expected effect, but due to the fact that any damage, including surgical damage, leads to the development of an immunodeficiency state.In such cases, the use of new techniques based on the use of immunotropic drugs is promising.It has been shown that the effectiveness of the wound-healing effect of thymogen and ribav is determined by the size of the defect, before or after the start of bioregulatory therapy, and treatment methods.It has been established that for wounds complicated by a fracture of the femur in outbred rats, the use of 5-day. A course of thymogen against the background of the use of kollapan-L causes more pronounced osteogenesis and ensures the formation of a more mature callus on the 45th day than in the control.Damage to the hooves of moose breeding stock reaches a 30% level. The main reason for this, in contrast to wild livestock, is the violation of housing and feeding. The inclusion of thymogen in complex therapy helps restore the clinical status of animals, as well as reduce the inflammatory reaction, endogenous and bacterial intoxication, and increase adaptive reactions, as evidenced by the dynamics of integral leukocyte indices.Application 5 days course of thymogen starting immediately after castration 5 months. boars in combination with etiotropic drugs helped to reduce the intensity of local reactions, the number of postoperative complications by four times, increased safety by 14.29%, average daily gains in live weight, and the production of meat products compared to the control of the highest category, in terms of cost when sold. The use of ribav was also effective, but less technologically advanced for mass processing of livestock.