bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE TIME-DOMAIN SPECTROSCOPIC SURVEY: UNDERSTANDING THE OPTICALLY VARIABLE SKY WITH SEQUELS IN SDSS-III
Authors: Ruan John J. , Anderson Scott F. , Green Paul J. , Morganson Eric , Eracleous Michael , Myers Adam D. , Badenes Carles , Bershady Matthew A. , Brandt William N. , Chambers Kenneth C. , Davenport James R. A. , Dawson Kyle S. , Flewelling Heather , Heckman Timothy M. , Isler Jedidah C. , Kaiser Nick , Kneib Jean-Paul , MacLeod Chelsea L. , Paris Isabelle , Ross Nicholas P. , Runnoe Jessie C. , Schlafly Edward F. , Schmidt Sarah J. , Schneider Donald P. , Schwope Axel D. , Shen Yue , Stassun Keivan G. , Szkody Paula , Waters Christoper Z. , York Donald G. 
Published: July 2016

ABSTRACT
The Time-Domain Spectroscopic Survey (TDSS) is an SDSS-IV eBOSS subproject primarily aimed at obtaining identification spectra of ∼220,000 optically variable objects systematically selected from SDSS/Pan-STARRS1 multi-epoch imaging. We present a preview of the science enabled by TDSS, based on TDSS spectra taken over ∼320 deg2 of sky as part of the SEQUELS survey in SDSS-III, which is in part a pilot survey for eBOSS in SDSS-IV. Using the 15,746 TDSS-selected single-epoch spectra of photometrically variable objects in SEQUELS, we determine the demographics of our variability-selected sample and investigate the unique spectral characteristics inherent in samples selected by variability. We show that variability-based selection of quasars complements color-based selection by selecting additional redder quasars and mitigates redshift biases to produce a smooth quasar redshift distribution over a wide range of redshifts. The resulting quasar sample contains systematically higher fractions of blazars and broad absorption line quasars than from color-selected samples. Similarly, we show that M dwarfs in the TDSS-selected stellar sample have systematically higher chromospheric active fractions than the underlying M-dwarf population based on their Hα emission. TDSS also contains a large number of RR Lyrae and eclipsing binary stars with main-sequence colors, including a few composite-spectrum binaries. Finally, our visual inspection of TDSS spectra uncovers a significant number of peculiar spectra, and we highlight a few cases of these interesting objects. With a factor of ∼15 more spectra, the main TDSS survey in SDSS-IV will leverage the lessons learned from these early results for a variety of time-domain science applications.
MAPPING THE MONOCEROS RING IN 3D WITH PAN-STARRS1
Authors: Morganson Eric , Conn Blair , Rix Hans-Walter , Bell Eric F. , Burgett William S. , Chambers Kenneth , Dolphin Andrew , Draper Peter W. , Flewelling Heather , Hodapp Klaus , Kaiser Nick , Magnier Eugene A. , Martin Nicolas F. , Martinez-Delgado David , Metcalfe Nigel , Schlafly Edward F. , Slater Colin T. , Wainscoat Richard J. , Waters Christopher Z. 
Published: July 2016

ABSTRACT
Using the Pan-STARRS1 survey, we derive limiting magnitude, spatial completeness, and density maps that we use to probe the three-dimensional structure and estimate the stellar mass of the so-called Monoceros Ring. The Monoceros Ring is an enormous and complex stellar sub-structure in the outer Milky Way disk. It is most visible across the large Galactic Anticenter region,

,

. We estimate its stellar mass density profile along every line of sight in 2° × 2° pixels over the entire 30,000 deg2 Pan-STARRS1 survey using the previously developed match software. By parsing this distribution into a radially smooth component and the Monoceros Ring, we obtain its mass and distance from the Sun along each relevant line of sight. The Monoceros Ring is significantly closer to us in the south (6 kpc) than in the north (9 kpc). We also create 2D cross-sections parallel to the Galactic plane that show 135° of the Monoceros Ring in the south and 170° of the Monoceros Ring in the north. We show that the northern and southern structures are also roughly concentric circles, suggesting that they may be waves rippling from a common origin. Excluding the Galactic plane

, we observe an excess mass of

across

. If we interpolate across the Galactic plane, we estimate that this region contains

. If we assume (somewhat boldly) that the Monoceros Ring is a set of two Galactocentric rings, its total mass is

. Finally, if we assume that it is a set of two circles centered at a point 4 kpc from the Galactic center in the anti-central direction, as our data suggests, we estimate its mass to be

.
Milda
Authors: Bromberger Christian 
Published: July 2016

La Lettone Milda (Ottovna) Bulle est une figure d’exception, aujourd’hui oubliée, de la révolution russe et des premières années du régime soviétique. Après avoir guerroyé en Azerbaïjan, contribué à l’éphémère République socialiste soviétique d’Iran, elle rejoint Moscou où, après une formation à l’Académie militaire, elle devient la première femme à porter le titre équivalent à général de brigade. Elle occupe des fonctions au nkid et au Komintern où elle milite contre les discriminations faites aux femmes dans le monde puis est muté en Bachkirie où elle contribue à la diffusion et à l’essor des cultures russe et bachkir. Elle n’échappe pas à la « grande purge stalinienne ». Figure d’exception pour avoir transgressé les frontières tracées par l’origine nationale, par la parenté, par le genre, Milda n’est pas pour autant une héroïne consacrée par l’histoire.
Katjusha
Authors: de Rapper Gilles 
Published: July 2016

Cet article se propose de brosser le portrait de la photographe personnelle d’Enver Hoxha en mettant en évidence sa position unique et ambiguë, sur la frontière du public et du privé, au sein de l’organisation totalitaire de la production photographique. Cette unicité et cette ambiguïté peuvent être vues comme à l’origine de sa perception, par elle-même et par les autres, en tant que « figure d’exception », ce qui permet de poser la question du statut de l’exceptionnel dans l’Albanie communiste.
Catherine
Authors: Mahieddin Emir 
Published: July 2016

Cet article étudie le parcours d’une femme qui a été, fait assez rare, pasteure d’une grande congrégation pentecôtiste, à Jönköping dans le sud de la Suède, entre 2009 et 2012. Ce cas, bien que singulier, permet de saisir l’histoire sociale de l’ensemble du mouvement pentecôtiste en Suède. La figure religieuse de Catherine est aussi un support de réflexion sur la question de la conception de la personne dans le christianisme et sur la manière dont on peut penser les individus exceptionnels en anthropologie.
« Depé »
Authors: Lestrelin Ludovic 
Published: July 2016

Si le football professionnel produit de « grands hommes », les individualités consacrées ne sont pas toujours celles qu’on croit. Cet article décrit la trajectoire hors du commun d’un supporter de l’Olympique de Marseille. De spectateur anonyme à leader reconnu au stade, il est devenu un personnage renommé de la ville, objet de célébration après son décès. L’auteur étudie les discours à son sujet rapportés aux configurations sociales au sein desquelles il a évolué et met en évidence la réversibilité de la réception propre aux figures d’exception.
D’une mondialisation oubliée
Authors: Foucher-Dufoix Valérie , Dufoix Stéphane 
Published: July 2016

à la fin des années 1940, en France, une expérience politique singulière a été menée par un petit groupe de personnes se présentant comme des citoyens du monde. Ils se proposaient d’œuvrer pour la mise en place d’une représentation mondiale des peuples, préalable à l’instauration d’une paix mondiale durable. L’un des moyens utilisés était la « mondialisation » des territoires, par laquelle ces derniers pouvaient déclarer leur appartenance au monde. L’étude de la mondialisation de Cahors au cours de cette période invite à s’interroger sur le lexique mondialiste de cette expérience, sur l’oubli assez général dans lequel est tombé cette entreprise, ainsi que sur ses réminiscences implicites dans les projets plus contemporains de réorganisation de la gouvernance mondiale.
Régulation différée et apprentissage en sport collectif
Authors: Mougenot Lucie 
Published: July 2016

Une approche constructiviste de l’apprentissage en sport collectif implique le recours à une régulation de l’enseignement et de l’apprentissage. Le rôle actif des évaluations formatives (Allal, 1991 ; Scallon, 2000) s’inscrit dans ce cadre comme un dispositif efficace pour optimiser la progression des élèves. Or les effets réels de tels dispositifs sont difficilement mesurables au quotidien. Nous nous sommes intéressés à l’impact de la mise en place d’évaluations formatives différées sur l’apprentissage en EPS, dans le but de préciser les domaines spécifiques de progression. Une étude de type ingénierie didactique a été menée dans le secondaire en EPS ( n = 46). Deux classes ont suivi une séquence d’apprentissage identique, mais une seule a bénéficié d’évaluations formatives à régulation différée (Allal, 1988). Les principaux résultats montrent que seul ce groupe ayant vécu des évaluations formatives différées, avec recours à la verbalisation et au débat d’idées, progresse de façon significative. Les élèves prennent des décisions plus pertinentes, se placent mieux pendant le jeu, ce qui entraîne une forte progression dans l’efficacité des actions motrices engagées.
Intorno al “lato destro de la terra”. Nuove proposte esegetiche sull’immaginario cosmografico e geoculturale di Ariosto
Authors: Spinelli Alice 
Published: July 2016

Lo scopo di quest’intervento, contestualizzato innanzitutto nel quadro dell’intenso dibattito critico sull’immaginario geografico di Ariosto (§ 1), è quello di suggerire una nuova lettura della formula « lato destro de la terra » (Orlando Furioso XXII, 24, 78). Secondo la mia tesi, tale formula, a differenza di quanto sinora postulato dalla critica, non si riferirebbe alle coordinate assolute dell’emisfero orientale del globo visualizzato su di un’immagine cartografica statica, ma piuttosto ad un sistema di orientamento relativo alla prospettiva soggettiva del personaggio in movimento. L’interpretazione qui avanzata si basa da una parte sul raffronto del verso citato con passi paralleli riscontrabili nel macrotesto del Furioso (§ 2.1), dall’altra sull’analisi delle mappae mundi alle quali il poeta ha potuto presumibilmente fare concreto ricorso (§ 2.2). In conclusione, il mio studio si propone di trarre da questa lettura puntuale delle indicazioni più generali sulle premesse epistemologiche del poema (§ 3), mostrando come l’ecumene tolemaica – seppur con integrazioni e modifiche puntuali – sembri ancora marcare in larga misura l’orizzonte geografico di riferimento dell’Ariosto.
The Four Continents e le rappresentazioni d’Europa tra retorica e storia (XIX-XX secolo)
Authors: Verga Marcello 
Published: July 2016

Due immagini d’Europa si sono consolidate e convivevano nella cultura europea della prima età moderna : l’immagine dell’Europa, continente tra i continenti, civiltà tra le altre civiltà, certamente superiore agli altri continenti e alle altre civiltà ; e, dall’altro lato, l’immagine di un’Europa divisa al suo interno in popoli – nazioni o stati. Allo stesso tempo l’immagine dell’Europa è stata frazionata secondo un asse nord-sud (un’Europa del nord che domina il sud) ed insieme lungo un asse ovest-est (una ‚vera’ Europa occidentale che esclude l’est come Europa non-europea). La storia d’Europa e dell’idea d’Europa, al di là di ogni tentativo di sistemazione in un racconto lineare di costruzione di una comune identità, che ha le sue « radici » in lontani processi culturali e religiosi, politici e sociali, resta pur sempre una storia difficile da scrivere. Riprendendo le tesi di Cassano, la soluzione proposta dall’articolo è un’ “alternativa mediterranea” che serva a riposizionare l’Europa nello scenario globale. Potrebbe dare un diverso e più consapevole valore civile e umano alla costruzione di una Unione Europea, che non si limiti a guardare il Sud, il suo Mediterraneo, ma che si costruisca a partire da quel Mediterraneo, dove si incrociano culture, società, religioni, la cui diversità è un punto di forza e di contrasto alla semplicistica reductio ad unum che una certa globalizzazione vorrebbe affermare.
Identification of Evolutionarily Conserved Md1 Splice Variants That Regulate Innate Immunity through Differential Induction of NF-кB
Authors: Candel Sergio , Tyrkalska Sylwia D. , García-Moreno Diana , Meseguer José , Mulero Victoriano 
Published: July 2016

Abstract
Although in mammals the TLR4/myeloid differentiation factor (MD)2/CD14 complex is responsible for the recognition of bacterial LPS, and it is known that the RP105/MD1 complex negatively regulates TLR4 signaling, the evolutionary history of LPS recognition remains enigmatic. Thus, zebrafish has orthologs of mammalian TLR4 (Tlr4a and Tlr4b), RP105, and MD1, but MD2 and CD14 seem to be absent from all fish genomes available to date. In addition, and to make the story more intriguing, zebrafish Tlr4a and Tlr4b do not recognize LPS, whereas the zebrafish Rp105/Md1 complex unexpectedly participates in the regulation of innate immunity and viral resistance. In this work, we report the identification of two novel splice variants of Md1, which are expressed at similar levels as full-length Md1 in the main immune-related organs of zebrafish and are highly induced upon viral infection. One of these splice variants, which is also expressed by mouse macrophages, lacks three conserved cysteine residues that have been shown to form disulfide bonds that are crucial for the three-dimensional structure of the MD-2–related lipid recognition domain of Md1. Functional studies in zebrafish demonstrate that this evolutionarily conserved splice variant shows higher antiviral activity than full-length Md1, but reduced proinflammatory activity, due to an impaired ability to activate the master regulator of inflammation, NF-κB. These results uncover a previously unappreciated evolutionarily conserved Md1 splice variant with important functions in the regulation of innate immunity and the antiviral response in zebrafish, and point to the need for additional functional studies in mammals on this little explored molecule.
Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors
Authors: Cao Xin , Lu Ying , Zhang Xianyu , Kovalovsky Damian 
Published: July 2016

Abstract
Expression of the transcription factor Zbtb1 is required for normal lymphoid development. We report in the present study that Zbtb1 maintains genome integrity in immune progenitors, without which cells undergo increased DNA damage and p53-mediated apoptosis during replication and differentiation. Increased DNA damage in Zbtb1-mutant (ScanT) progenitors was due to increased sensitivity to replication stress, which was a consequence of inefficient activation of the S-phase checkpoint response. Increased p53-mediated apoptosis affected not only lymphoid but also myeloid development in competitive bone marrow chimeras, and prevention of apoptosis by transgenic Bcl2 expression and p53 deficiency rescued lymphoid as well as myeloid development from Zbtb1-mutant progenitors. Interestingly, however, protection from apoptosis rescued only the early stages of T cell development, and thymocytes remained arrested at the double-negative 3 developmental stage, indicating a strict requirement of Zbtb1 at later T cell developmental stages. Collectively, these results indicate that Zbtb1 prevents DNA damage in replicating immune progenitors, allowing the generation of B cells, T cells, and myeloid cells.
Dual Inhibition of Rip2 and IRAK1/4 Regulates IL-1β and IL-6 in Sarcoidosis Alveolar Macrophages and Peripheral Blood Mononuclear Cells
Authors: Talreja Jaya , Talwar Harvinder , Ahmad Nisar , Rastogi Ruchi , Samavati Lobelia 
Published: July 2016

Abstract
Sarcoidosis is a multisystem granulomatous disease of unknown etiology that primarily affects the lungs. Our previous work indicates that activation of p38 plays a pivotal role in sarcoidosis inflammatory response. Therefore, we investigated the upstream kinase responsible for activation of p38 in sarcoidosis alveolar macrophages (AMs) and PBMCs. We identified that sustained p38 phosphorylation in sarcoidosis AMs and PBMCs is associated with active MAPK kinase 4 but not with MAPK kinase 3/6. Additionally, we found that sarcoidosis AMs exhibit a higher expression of IRAK1, IRAK-M, and receptor interacting protein 2 (Rip2). Surprisingly, ex vivo treatment of sarcoidosis AMs or PBMCs with IRAK1/4 inhibitor led to a significant increase in IL-1β mRNA expression both spontaneously and in response to TLR2 ligand. However, a combination of Rip2 and IRAK-1/4 inhibitors significantly decreased both IL-1β and IL-6 production in sarcoidosis PBMCs and moderately in AMs. Importantly, a combination of Rip2 and IRAK-1/4 inhibitors led to decreased IFN-γ and IL-6 and decreased percentage of activated CD4+CD25+ cells in PBMCs. These data suggest that in sarcoidosis, both pathways, namely IRAK and Rip2, are deregulated. Targeted modulation of Rip2 and IRAK pathways may prove to be a novel treatment for sarcoidosis.
G2A Signaling Dampens Colitic Inflammation via Production of IFN-γ
Authors: Frasch S. Courtney , McNamee Eóin N. , Kominsky Douglas , Jedlicka Paul , Jakubzick Claudia , Zemski Berry Karin , Mack Matthias , Furuta Glenn T. , Lee James J. , Henson Peter M. , Colgan Sean P. , Bratton Donna L. 
Published: July 2016

Abstract
Proinflammatory consequences have been described for lysophosphatidylcholine, a lipid product of cellular injury, signaling via the G protein–coupled receptor G2A on myeloid and lymphoid inflammatory cells. This prompted the hypothesis that genetic deletion of G2A would limit intestinal inflammation in a mouse model of colitis induced by dextran sodium sulfate. Surprisingly, G2A−/− mice exhibited significantly worsened colitis compared with wild-type mice, as demonstrated by disease activity, colon shortening, histology, and elevated IL-6 and IL-5 in colon tissues. Investigation of inflammatory cells recruited to inflamed G2A−/− colons showed significantly more TNF-α+ and Ly6ChiMHCII− proinflammatory monocytes and eosinophils than in wild-type colons. Both monocytes and eosinophils were pathogenic as their depletion abolished the excess inflammation in G2A−/− mice. G2A−/− mice also had less IFN-γ in inflamed colon tissues than wild-type mice. Fewer CD4+ lymphocytes were recruited to inflamed G2A−/− colons, and fewer colonic lymphocytes produced IFN-γ upon ex vivo stimulation. Administration of IFN-γ to G2A−/− mice during dextran sodium sulfate exposure abolished the excess colitic inflammation and reduced colonic IL-5 and eosinophil numbers to levels seen in wild-type mice. Furthermore, IFN-γ reduced the numbers of TNF-α+ monocyte and enhanced their maturation from Ly6ChiMHCII− to Ly6CintMHCII+. Taken together, the data suggest that G2A signaling serves to dampen intestinal inflammation via the production of IFN-γ, which, in turn, enhances monocyte maturation to a less inflammatory program and ultimately reduces eosinophil-induced injury of colonic tissues.
Impact of Staphylococcus aureus USA300 Colonization and Skin Infections on Systemic Immune Responses in Humans
Authors: Alegre Maria-Luisa , Chen Luqiu , David Michael Z. , Bartman Caroline , Boyle-Vavra Susan , Kumar Neha , Chong Anita S. , Daum Robert S. 
Published: July 2016

Abstract
Staphylococcus aureus is both a commensal and a pathogen, and USA300, a strain that is usually methicillin-resistant but can sometimes be methicillin-susceptible, has been causing skin and soft tissue infections (SSTIs) in epidemic proportions among otherwise healthy individuals. Although many people are colonized with S. aureus strains, including some with USA300, few of these colonized individuals develop SSTIs. This prompts the hypothesis that infections may develop in individuals with somewhat reduced innate and/or adaptive immune responses to S. aureus, either because prior S. aureus colonization has dampened such responses selectively, or because of more globally reduced immune reactivity. In this study, we analyzed the S. aureus colonization status and PBMC responses to innate and adaptive stimuli in 72 patients with SSTIs and 143 uninfected demographically matched controls. Contrary to the hypothesis formulated, PBMCs from infected patients obtained at the time of infection displayed enhanced innate cytokine production upon restimulation compared with PBMCs from controls, a difference that disappeared after infection resolution. Notably, PBMCs from patients infected with a documented USA300 SSTI displayed greater innate cytokine production than did those from patients infected with documented non-USA300 genotypes. Moreover, colonization with USA300 in infected patients, regardless of their infecting strain, correlated with increased production of IL-10, IL-17A, and IL-22 compared with patients colonized with non-USA300 subtypes. Thus, our results demonstrate that infected patients associated with USA300 either as an infecting strain, or as a colonizing strain, have systemic immune responses of greater magnitude than do those associated with other S. aureus subtypes.
Prevalence, Clinical Characteristics, and Predictors of Patients with Thromboembolic Events in Takotsubo Cardiomyopathy
Authors: El-Battrawy Ibrahim , Behnes Michael , Hillenbrand Dennis , Haghi Darius , Hoffmann Ursula , Papavassiliu Theano , Lang Siegfried , Fastner Christian , Becher Tobias , Baumann Stefan , Heggemann Felix , Kuschyk Jürgen , Borggrefe Martin , Akin Ibrahim 
Published: July 2016

Background Several acute complications related to takotsubo cardiomyopathy (TTC) have been documented recently. However, the incidence and clinical significance of acute thromboembolic events in TTC is not well established. Methods A detailed investigation of the clinical characteristics and in-hospital complications of 114 consecutive patients diagnosed with TTC between January 2003 and September 2015 was carried out. This study was initiated to reveal the predictors, clinical significance, and short-term and long-term outcomes of patients with TTC associated with acute thromboembolic events on index presentation. Results The incidence of acute thromboembolic events related to TTC was around 12.2%, and these included ventricular thrombi, cerebrovascular events, retinal and brachial artery pathologies, renal, splenic, and aortic involvement. The most frequent complication on initial presentation was cardiogenic shock (20%) accompanied with pulmonary congestion (20%). Interestingly, patients experiencing thromboembolic events had higher C-reactive protein (CRP) levels as compared to the non-thromboembolic group ( P = 0.02). Certain thromboembolic events were characterized by the presence of ST-segment elevation in electrocardiogram ( P 0.02). Chest pain was the primary symptom in these patients ( P 0.09). Furthermore, there was significant right ventricular involvement (as assessed by transthoracic echocardiography) in patients presenting with an acute thromboembolic event ( P 0.08). A Kaplan–Meier analysis indicated a significantly higher mortality rate over a mean follow-up of three years in the thromboembolic group than the non-thromboembolic group (log-rank, P = 0.02). Conclusions Our results confirmed the relative common occurrence of thromboembolic events in the setting of TTC. Inflammation might play an important role in the development of thromboembolic events, and a right ventricular involvement and ST-segment elevation could be positive predictors for this occurrence. In order to circumvent the risk of a negative outcome, it is recommended that an anticoagulation therapy be initiated in all high-risk patients.