bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparative study on the therapeutic effect of TRPV1, TRPA1, and TRPM8 agonists on swallowing dysfunction associated with aging and neurological diseases
Authors: Alvarez‐Berdugo D. , Rofes L. , Arreola V. , Martin A. , Molina L. , Clavé P. 
Published: August 2017

AbstractBackgroundOropharyngeal sensory impairment is a potential target to treat swallowing dysfunction in patients with oropharyngeal dysphagia (OD).AimTo assess the therapeutic effect of stimulating oropharyngeal sensory afferents with TRPV1, TRPA1, or TRPM8 agonists vs increasing bolus viscosity in older and neurologic patients with OD by comparing four studies of similar experimental design.MethodsSwallow function of 142 older patients with impaired safety of swallow at nectar ([50‐350] mPa·s) viscosity was evaluated with videofluoroscopy (VFS) while treated with TRPV1 (150 μmol/L), TRPV1/A1 (150 μmol/L and 1 mmol/L), or TRPM8 (1 mmol/L or 10 mmol/L) agonists or modified starch (MS) at spoon thick viscosity (>1750 mPa·s).ResultsTRPV1 stimulation with capsaicinoids reduced penetrations by 50%, pharyngeal residue by 80%, and LVC time by 24.38% and increased bolus velocity by 36.51%. TRPV1/A1 stimulation with piperine reduced penetrations by 56.32%, LVC time by 25.55% and increased bolus velocity by 23.63%. TRPM8 stimulation with menthol 1 mmol/L reduced penetrations by 37.5% while 10 mmol/L reduced LVC time by 18.44%. Thickeners reduced penetrations by 77.11%, but increased pharyngeal residue by 19.89%, delayed LVC by 41.73%, and reduced bolus velocity by 13.44%.ConclusionNatural capsaicinoids have a stronger therapeutic effect on VFS signs and swallow response by stimulating TRPV1 than TRPV1/A1 or TRPM8 agonists. While TRP stimulants increased bolus velocity and reduced swallow response times, thickeners reduced bolus velocity and further delayed the swallow response. This study sets the bases to develop new pharmacologic strategies for older patients with OD, moving away from compensation toward the recovery of swallow function.
Inaccuracy of patient‐reported descriptions of and satisfaction with bowel actions in irritable bowel syndrome
Authors: Halmos E. P. , Biesiekierski J. R. , Newnham E. D. , Burgell R. E. , Muir J. G. , Gibson P. R. 
Published: August 2017

AbstractBackgroundPerception of diarrhea and constipation differs greatly. This study aimed to correlate subjective and objective assessment of fecal characteristics in irritable bowel syndrome (IBS) patients.MethodsData from two interventional dietary trials with varying FODMAP (Fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols) or gluten content were interrogated. Subjects rated their dissatisfaction with stool consistency daily using a visual analog scale during the interventions. Subjects collected stools at the end of each intervention. Each stool was scored according to the King's Stool Chart (KSC). Fecal water content (FWC) was measured on pooled feces by freeze drying, with diarrhea defined as ≥78%.Key ResultsSeventy IBS (Rome III) and eight healthy subjects were studied. Each subject's self‐rating of stool consistency during the most symptomatic diet was approximately double that of their least. Degree of dissatisfaction with stool consistency correlated poorly with changes in FWC and KSC. IBS subtype related poorly to objective measures of stool consistency. Sixty percent of IBS‐D subjects had diarrhea on objective measures. Eighty‐five percent with IBS‐C had hard and formed stools but three patients met the criteria for diarrhea. One healthy subject had diarrhea on FWC and KSC, and six had hard, formed stools. No differences in FWC was observed when subjects consumed differing amounts of FODMAPs or gluten (all P > .200).Conclusions and InferencesThere are major disparities between patients’ stool descriptions and objective features of constipation and diarrhea. Patient‐reported bowel habits require more interrogation for accurate IBS subtyping. Varying FODMAP or gluten content of the diet is not associated with consistent change in FWC.
Convergent or Divergent? The Hidden Dynamics of Institutional Changes in the Labor Markets and Social Welfare Systems in South Korea and Japan
Authors: Cho Sungik , Choi Yool 
Published: August 2017

Dualization explains analogous changes in South Korea and Japan like labor market segmentation and the expansion of social protection for nonstandard workers. This study argues, however, that their institutional structures and underlying dynamics of dualization are more different than they appear, where the subcontracting relations between big businesses and their suppliers come into play. The co‐operative interfirm relations in Japan become a buffer with which firms incrementally adjust to a coupled dualization in the labor market and social welfare system. Thus, Japanese nonstandard workers excluded from the social insurance system exist because of the formally segmented structures of labor markets and social welfare programs. By contrast, the exploitative subcontracting relations in South Korea intensify labor market segmentation and undermine government regulation of labor and social welfare, leading to a decoupled dualization. Those in South Korea persist despite the formally inclusive and unified structures of social welfare programs.Related ArticlesLuckhurst,Jonathan.2012.“.”Politics & Policy40():958‐977.http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.2012.00386.x/abstractWagle,Udaya R.2013.“.”Politics & Policy41():947‐984.http://onlinelibrary.wiley.com/doi/10.1111/polp.12053/fullLuccisano,Lucy, andAmyRomagnoli.2007. “”Politics & Policy35():716‐751.http://onlinelibrary.wiley.com/doi/10.1111/j.1747-1346.2007.00082.x/abstractRelated MediaMiyamoto,Hiroaki.2016. “.”East Asia Forum.December 23.http://www.eastasiaforum.org/2016/12/23/reforming-japans-dual-labour-market/Park,S. Nathan.2015. “.”The Wall Street Journal.February 25.https://blogs.wsj.com/korearealtime/2015/02/25/south-koreas-labor-market-reform-struggles/
Frailty in nursing home residents: a scoping review protocol
Authors: De Silva Thanuja , Ahip Sally , Theou Olga , Tufanaru Catalin , Visvanathan Renuka , Umapathysivam Kandiah 
Published: August 2017

Objectives and Review questions:
The overall research objective of this scoping review is to determine the current evidence on frailty in nursing homes.
The objectives of the scoping review are to map the following, as reported in international literature:Fraily tools used in studies on nursing home residents.Prevalence of frailty in nursing home residents.Geriatric syndromes (e.g. cognitive impairment, delirium, depression, falls, incontinence, malnutrition and dizziness) associated with frailty in nursing home residents.Other types of adverse outcomes related to frailty reported.Diverse treatment modalities of frailty in nursing home residents.

The questions for the scoping review are:What frailty diagnostic tools have been reported in international literature that have been used in studies on nursing home residents?What prevalence rates of frailty in nursing home residents have been reported in the literature?What types of geriatric syndromes have been reported in the literature as being associated with frailty?What other types of adverse outcomes related to frailty have been reported in the literature?What treatment modalities for frailty have been reported in the literature?
Textual synthesis of policies and guidance statements for remote healthcare practitioners on managing medical emergencies in the oil and gas industry: a systematic review protocol
Authors: Osakwe Kennedy A. , Cooper Kay , Stewart Derek , Wainwright Cherry L. , Klein Susan 
Published: August 2017

Review question/objective:
: The objective of this review is to collate, synthesize and present the available evidence on the policies and guidance statements for remote healthcare practitioners on managing medical emergencies in the offshore oil and gas industry.
More specifically, the review seeks to answer the following questions:How is the derivation of these policies and guidance statements described?What is the content and areas of similarity and difference of the policies and guidance statements?What emphasis is placed on the implementation and evaluation within the policies and guidance statements?
Instruments for measuring undergraduate nursing students’ knowledge, attitudes and skills in evidence-based practice: a systematic review protocol
Authors: Cardoso Daniela , Santos Eduardo , Cardoso Maria L. , Oliveira Catarina R. , Rodrigues Manuel A. , Apóstolo João 
Published: August 2017

Review question/objective:
: The objective of this systematic review is to identify and assess the properties of instruments for measuring undergraduate nursing students’ knowledge, attitudes and skills in evidence-based practice (EBP).
More specifically, the review questions are as follows:What are the measurement properties of the available instruments for measuring undergraduate nursing students’ knowledge, attitudes and skills in EBP?What is the most valid and reliable instrument for measuring undergraduate nursing students’ knowledge, attitudes and skills in EBP?
Draft Genome Sequence of Mycobacterium avium 11
Authors: Yee Michelle , Klinzing David , Wei Jun-Rong , Gengenbacher Martin , Rubin Eric J. , Chien Jung-Yien , Hsueh Po-Ren , Dick Thomas 
Published: August 2017

ABSTRACT

Mycobacterium avium
accounts for most lung disease caused by nontuberculous mycobacteria (NTM). The lack of effective chemotherapy calls for the discovery of new drugs. Here, we report the draft genome sequence of
M. avium
11, a clinical isolate used as a screening strain for NTM-focused drug discovery.
Draft Genome Sequences of Yersinia frederiksenii, Yersinia intermedia, and Yersinia kristensenii Strains from Brazil
Authors: Imori Priscilla Fernanda Martins , Campioni Fábio , Cao Guojie , Kastanis George , Leon Maria Sanchez , Allard Marc William , Falcão Juliana Pfrimer 
Published: August 2017

ABSTRACTYersinia enterocolitica-like strains are usually understudied. In this work, we reported the draft genome sequences of twoYersinia frederiksenii, twoYersinia intermedia, and twoYersinia kristenseniistrains isolated from humans, animals, food, and the environment in Brazil. These draft genomes will provide better molecular characterizations of these species.
Whole-Genome Sequence of
Starmerella bacillaris
PAS13, a Nonconventional Enological Yeast with Antifungal Activity
Authors: Lemos Junior Wilson José Fernandes , Treu Laura , da Silva Duarte Vinícius , Carlot Milena , Nadai Chiara , Campanaro Stefano , Giacomini Alessio , Corich Viviana 
Published: August 2017

ABSTRACT

Starmerella bacillaris
is a fermentative yeast commonly found in vineyards. Here, we present the draft genome sequence of
S. bacillaris
PAS13, a nonconventional enological yeast with a potential role as a biocontrol agent. This gene sequence will provide insights into the genetic basis of yeast activity against gray mold disease (
Botrytis cinerea
).
Genome Sequence of
Oceanicola
sp. Strain MCTG156(1a), Isolated from a Scottish Coastal Phytoplankton Net Sample
Authors: Gutierrez Tony , Whitman William B. , Huntemann Marcel , Copeland Alex , Chen Amy , Vargese Neha , Kyrpides Nikos C. , Pillay Manoj , Ivanova Natalia , Mikhailova Natalia , Mukherjee Supratim , Stamatis Dimitrios , Reddy T. B. K. , Ngan Chew Yee , Chovatia Mansi , Daum Chris , Shapiro Nicole , Woyke Tanja 
Published: August 2017

ABSTRACT

Oceanicola
sp. strain MCTG156(1a) was isolated from a phytoplankton net sample collected on the west coast of Scotland and selected based on its ability to degrade polycyclic aromatic hydrocarbons. Here, we present the genome sequence of this strain, which comprises 3,881,122 bp with 3,949 genes and an average G+C content of 62.7%.
Draft Genome Sequence of Thiohalobacter thiocyanaticus Strain FOKN1, a Neutrophilic Halophile Capable of Thiocyanate Degradation
Authors: Oshiki Mamoru , Fukushima Toshikazu , Kawano Shuichi , Nakagawa Junichi 
Published: August 2017

ABSTRACT

A draft genome sequence of a neutrophilic halophile capable of thiocyanate degradation,
Thiohalobacter thiocyanaticus
FOKN1, was determined using a PacBio RSII sequencer. A 3.23-Mb circular genome sequence was assembled, in which 3,026 gene-coding sequences, 45 tRNAs, and 1
rrn
operon were annotated.
Complete Genome Sequence of Anoxybacillus flavithermus Strain 52-1A Isolated from a Heat-Processed Powdered Milk Concentrate
Authors: Tasara Taurai , Morach Marina , Klumpp Jochen , Stephan Roger 
Published: August 2017

ABSTRACT

The thermophilic spore-forming bacterium
Anoxybacillus flavithermus
is responsible for powdered milk product spoilage, and its presence in dairy processing environments is a concern. Here, the complete genome sequence of the
A. flavithermus
strain 52-1A isolated from a heat-processed powdered milk product concentrate in Switzerland is presented.
Therapeutic options for bleeding oesophageal varices: cyanoacrylate and balloon-occluded retrograde obliteration (BRTO)
Authors: Frischtak Helena L , Davis Jessica P , Shah Neeral L 
Published: August 2017

A 56-year-old male with cirrhosis presented with acute bleeding from cardiofundal gastroesophageal varices (GOV) and was treated with endoscopic cyanoacrylate glue. Glue therapy achieved stabilisation of the patient in the emergent setting. Three months later, the patient suffered rebleeding. At that time, he underwent retreatment with balloon-occluded retrograde obliteration (BRTO), with no recurrence at a follow-up of 14 months.Available treatments for bleeding GOV include methods to (a) directly obstruct the varices (endoscopic variceal ligation , sclerotherapy and cyanoacrylate glue, BRTO) or to (b) decrease portal pressure (surgical portacaval shunts; transportal intrahepatic portosystemic shunt). No precise guidelines are available regarding when to use which modality, and few centres have experience with all of them. This case report illustrates a setting in which both options of cyanoacrylate glue therapy and BRTO were used for acute gastric variceal bleeding.
Severe dysphagia requiring gastrostomy following cervical spine fracture fixation
Authors: Bailey Joanelle A , Lavery Robert F , Adams John M , Livingston Andrew S , DiFazio Lou , Livingston David H 
Published: August 2017

BackgroundThe incidence of severe dysphagia requiring gastrostomy tube (GT) placement following operative fixation of traumatic cervical spine fractures is unknown. Risk factors for severe dysphagia are not well identified and GT placement is often delayed due to the belief that it will resolve quickly. We hypothesized that patient and clinical factors could be used to predict severe dysphagia requiring GT placement in this population.MethodsA retrospective multicenter review of all adult patients requiring operative fixation of cervical spine fractures was performed. Data on demographics, injury severity score, presence of spinal cord injury, operative approach, presence of severe traumatic brain injury, and the need and timing of tracheostomy and GT were collected. The timing, number and results of formal speech, and language pathology examinations were also recorded.Results243 patients underwent cervical spine fixation for traumatic fractures, of which 72 (30%) required GT placement. Patients requiring gastrostomy were significantly older, 54 versus 45 years (p=0.002), and had higher injury severity scores at 24 versus 18 (p<0.0001). Tracheostomy was strongly associated with severe dysphagia; GT was required in 83% of patients who underwent tracheostomy versus 5% of those who did not require tracheostomy. 50% of patients underwent tracheostomy and GT on the same day after injury, with the remaining patients having an average of 9 days delay between procedures. The need for gastrostomy placement was also higher in patients undergoing combined operative approach versus anterior or posterior approach alone (p=0.02). There were no GT-related complications.ConclusionsSevere dysphagia requiring GT placement occurs commonly (30%) in patients who undergo operative fixation of cervical spine fractures. Gastrostomy placement was delayed in 50%. Tracheostomy was strongly associated with the need for GT placement. Earlier GT placement, especially in patients requiring tracheostomy, would improve patient care and disposition.
The Tangible Desktop
Authors: Baldwin Mark S. , Hayes Gillian R. , Haimson Oliver L. , Mankoff Jennifer , Hudson Scott E. 
Published: August 2017

Audio-only interfaces, facilitated through text-to-speech screen reading software, have been the primary mode of computer interaction for blind and low-vision computer users for more than four decades. During this time, the advances that have made visual interfaces faster and easier to use, from direct manipulation to skeuomorphic design, have not been paralleled in nonvisual computing environments. The screen reader–dependent community is left with no alternatives to engage with our rapidly advancing technological infrastructure. In this article, we describe our efforts to understand the problems that exist with audio-only interfaces. Based on observing screen reader use for 4 months at a computer training school for blind and low-vision adults, we identify three problem areas within audio-only interfaces: ephemerality, linear interaction, and unidirectional communication. We then evaluated a multimodal approach to computer interaction called the Tangible Desktop that addresses these problems by moving semantic information from the auditory to the tactile channel. Our evaluation demonstrated that among novice screen reader users, Tangible Desktop improved task completion times by an average of 6 minutes when compared to traditional audio-only computer systems.
Unipolar Endocardial Voltage Mapping in the Right Ventricle
Authors: Venlet Jeroen , Piers Sebastiaan R.D. , Kapel Gijsbert F.L. , de Riva Marta , Pauli Philippe F.G. , van der Geest Rob J. , Zeppenfeld Katja 
Published: August 2017

Background—
Low endocardial unipolar voltage (UV) at sites with normal bipolar voltage (BV) may indicate epicardial scar. Currently applied UV cutoff values are based on studies that lacked epicardial fat information. This study aimed to define endocardial UV cutoff values using computed tomography–derived fat information and to analyze their clinical value for right ventricular substrate delineation.

Methods and Results—
Thirty-three patients (50±14 years; 79% men) underwent combined endocardial–epicardial right ventricular electroanatomical mapping and ablation of right ventricular scar–related ventricular tachycardia with computed tomographic image integration, including computed tomography–derived fat thickness. Of 6889 endocardial–epicardial mapping point pairs, 547 (8%) pairs with distance <10 mm and fat thickness <1.0 mm were analyzed for voltage and abnormal (fragmented/late potential) electrogram characteristics. At sites with endocardial BV >1.50 mV, the optimal endocardial UV cutoff for identification of epicardial BV <1.50 mV was 3.9 mV (area under the curve, 0.75; sensitivity, 60%; specificity, 79%) and cutoff for identification of abnormal epicardial electrogram was 3.7 mV (area under the curve, 0.88; sensitivity, 100%; specificity, 67%). The majority of abnormal electrograms (130 of 151) were associated with transmural scar. Eighty-six percent of abnormal epicardial electrograms had corresponding endocardial sites with BV <1.50 mV, and the remaining could be identified by corresponding low endocardial UV <3.7 mV.

Conclusions—
For identification of epicardial right ventricular scar, an endocardial UV cutoff value of 3.9 mV is more accurate than previously reported cutoff values. Although the majority of epicardial abnormal electrograms are associated with transmural scar with low endocardial BV, the additional use of endocardial UV at normal BV sites improves the diagnostic accuracy resulting in identification of all epicardial abnormal electrograms at sites with <1.0 mm fat.
Fabry Disease in Families With Hypertrophic Cardiomyopathy
Authors: Adalsteinsdottir Berglind , Palsson Runolfur , Desnick Robert J. , Gardarsdottir Marianna , Teekakirikul Polakit , Maron Martin , Appelbaum Evan , Neisius Ulf , Maron Barry J. , Burke Michael A. , Chen Brenden , Pagant Silvere , Madsen Christoffer V. , Danielsen Ragnar , Arngrimsson Reynir , Feldt-Rasmussen Ulla , Seidman Jonathan G. , Seidman Christine E. , Gunnarsson Gunnar Th. 
Published: August 2017

Background—

The screening of Icelandic patients clinically diagnosed with hypertrophic cardiomyopathy resulted in identification of 8 individuals from 2 families with X-linked Fabry disease (FD) caused by
GLA
(α-galactosidase A gene) mutations encoding p.D322E (family A) or p.I232T (family B).

Methods and Results—
Familial screening of at-risk relatives identified mutations in 16 family A members (8 men and 8 heterozygotes) and 25 family B members (10 men and 15 heterozygotes). Clinical assessments, α-galactosidase A (α-GalA) activities, glycosphingolipid substrate levels, and in vitro mutation expression were used to categorize p.D322E as a classic FD mutation and p.I232T as a later-onset FD mutation. In vitro expression revealed that p.D322E and p.I232T had α-GalA activities of 1.4% and 14.9% of the mean wild-type activity, respectively. Family A men had markedly decreased α-GalA activity and childhood-onset classic manifestations, except for angiokeratoma and cornea verticillata. Family B men had residual α-GalA activity and developed FD manifestations in adulthood. Despite these differences, all family A and family B men >30 years of age had left ventricular hypertrophy, which was mainly asymmetrical, and had similar late gadolinium enhancement patterns. Ischemic stroke and severe white matter lesions were more frequent among family A men, but neither family A nor family B men had overt renal disease. Family A and family B heterozygotes had less severe or no clinical manifestations.

Conclusions—

Men with classic or later-onset FD caused by
GLA
missense mutations developed prominent and similar cardiovascular disease at similar ages, despite markedly different α-GalA activities.
Health-Illness Transition Experiences With Type 2 Diabetes Self-management of Sub-Saharan African Immigrants in the United States
Authors: Kindarara Désiré M. , McEwen Marylyn M. , Crist Janice D. , Loescher Lois J. 
Published: August 2017

Purpose The purpose of this study was to describe Sub-Saharan African immigrants’ health-illness transition experiences associated with type 2 diabetes mellitus (T2DM) self-management. Methods A qualitative description methodology was used in this study. Face-to-face semi-structured in-depth interviews lasting 60 to 90 minutes were conducted with 10 Sub-Saharan African immigrant men and women with T2DM recruited using purposive and snowball sampling. Each interview was audio-taped, transcribed, and analyzed using qualitative content analysis. Results Participants’ mean age was 60.3 years (range, 44-76 years), 5 men and 5 women; most had lived in the US for more than 10 years (70%) and with T2DM for more than 5 years (60%). Four overarching domains described the health-illness transition experiences the participants had with T2DM self-management: (1) knowledge of T2DM self-management behaviors, (2) current T2DM self-management behaviors, (3) inhibitors of T2DM self-management, and (4) facilitators of T2DM self-management. Conclusions Health professionals should be equipped with an understanding of the properties and conditions of health-illness transition. This understanding is necessary to build a foundation that facilitates healthy adaptation to the T2DM transition requiring the development and mastery of new skills consistent with gaining control of T2DM. Culturally tailored interventions need to be developed to decrease inhibitors of and encourage self-management in daily T2DM care for Sub-Saharan African immigrants with T2DM.