bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of spatial resolution effects in rough wall-bounded turbulence
Authors: Xia Y. , Chung D. , Marusic I. , Hutchins N. , Abu Rowin W. 
Published: September 2024

AbstractThis study investigates the impact of insufficient spanwise spatial resolution on the measurement accuracy of streamwise velocity fluctuations over rough walls. We use a direct numerical simulation (DNS) database of turbulent open-channel flow over three-dimensional sinusoidal roughness with varied wavelengths and roughness heights. Employing a triple decomposition, we investigate both the attenuation of the turbulent fluctuations (about the local mean), $$u^\prime$$

u
′

and the dispersive stresses (roughness-induced fluctuations of the time-averaged mean about the global mean), $${\tilde{U}}$$

U
~

. A boxcar filter on DNS data is applied to investigate the effects of spanwise spatial filtering on these quantities. Our analysis reveals the significance of two key length-scale ratios for velocity measurements over rough walls: the wire length relative to the spatially and temporally plane-averaged Kolmogorov scale at the roughness crest ($$l/\langle \eta \rangle _k$$

l
/

⟨
η
⟩

k

), and the wire length relative to the roughness spanwise wavelength ($$l/\Lambda _y$$

l
/

Λ
y

). We observe that maintaining $$l/\langle \eta \rangle _k$$

l
/

⟨
η
⟩

k

constant while increasing $$l/\Lambda _y$$

l
/

Λ
y

attenuates the variance of $${\tilde{U}}$$

U
~

and $$u^\prime$$

u
′

within the roughness sublayer. When fixing $$l/\Lambda _y$$

l
/

Λ
y

, an increase in $$l/\langle \eta \rangle _k$$

l
/

⟨
η
⟩

k

influences the turbulent fluctuations across all wall-normal locations. These findings highlight the necessity of considering both length scales when evaluating spanwise spatial resolution in turbulence measurements over rough walls.
Integrated rather than organic farming history facilitates soil nitrogen turnover and N2O reduction in a green rye – silage maize cropping sequence
Authors: Khan Fawad , Franco-Luesma Samuel , Dannenmann Michael Ulrich , Gasche Rainer , Gattinger Andreas , Hartmann Frederik , Tobisch Beatrice , Kiese Ralf , Wolf Benjamin 
Published: October 2024

AbstractSoil gross mineral N production and consumption processes are crucial regulators of plant productivity and N loss from croplands. Substituting synthetic fertilizers by integrating legumes in cultivation systems is common in organic farming, but research on its long-term impact on dynamics of gross soil N transformation and associated environmental N loss is scarce. In particular, studies at a temporal resolution that allows for a mechanistic understanding of long-term effects of organic farming are missing. Therefore, we determined gross N turnover rates of ammonification, nitrification, and ammonium and nitrate immobilization at monthly temporal resolution during a full green rye-maize cropping sequence. Measurements were carried out at sites with same pedo-climatic background but organic farming (OF) and integrated farming (IF) history. During green rye growing, N turnover rates for OF and IF were low and not significantly different, likely owing to low temperatures. During silage maize growing, IF exhibited significantly higher average N turnover rates of 1.86, 4.46, and 5.57 mg N kg⁻1 dry soil d⁻1 for gross ammonification, ammonium immobilization, and nitrate immobilization, respectively, compared to OF values of 1.11, 1.80, and 2.90 mg N kg⁻1 dry soil d⁻1. The significantly higher N turnover rates were likely due to higher soil organic C, N and microbial biomass which result from different long-term management practices. Especially the increased immobilization potential on the IF site contributed to significantly lower area-scaled N₂O emissions (1.45 vs. 4.36 kg N ha⁻1) during periods of high nitrification. This shows that for low SOC soils, integrated farming history with high C return enhances soil N cycling and reduces the risk of N losses in the form of N2O emission.
The combination of transarterial chemoembolization and microwave ablation is superior to microwave ablation alone for liver metastases from colorectal cancer
Authors: Vogl Thomas J. , Stefan Hannah , Gruber-Rouh Tatjana , Trojan Jörg , Bechstein Wolf Otto , Bielfeldt John , Adwan Hamzah 
Published: October 2024

Abstract
Objectives
This study aimed to compare the combination therapy of transarterial chemoembolization (TACE) and microwave ablation (MWA) with MWA alone in treating liver metastases from colorectal cancer (LMCRC).

Materials and methods
In this retrospective study, a total of 251 patients with unresectable and not to chemotherapy responding LMCRC were included. Group A consisted of 184 patients (104 male and 80 females; mean age: 64 ± 11.4 years) with 442 metastases who received a combination of TACE and MWA. A total of 67 patients (49 male and 18 females; mean age: 63.2 ± 11.8 years) with 173 metastases patients were included in group B, who received only MWA. Parameters assessed were local tumor progression (LTP), hepatic distant tumor progression (hDTP), hepatic progression-free survival (hPFS), and overall survival (OS).

Results
The rate of LTP was 4.9% in group A and 4.5% in group B (p-value: 0.062). The rate of hDTP was 71.7% and 83.6% for groups A and B (p-value: 0.81), respectively. The mean hPFS was 13.8 months (95% CI 10.9–16.8) for group A and 8.1 months (95% CI 6.1–10.1) for group B (p-value: 0.03). The median OS time for group A was 30 months (95% CI 26–34), with 1-, 2-, 3-, and 4-year OS rates of 84.2%, 61.1%, 40.8% and 31.3%, respectively. In group B however, the median OS time was 26 months (95% CI 18–34) with 1-, 2-, 3-, and 4-year OS rates of 82.3%, 53.2%, 34.6% and 28.2%, respectively (p-value: 0.67).

Conclusion
The combination therapy of TACE and MWA is superior to the monotherapy of MWA for LMCRC, especially regarding hDTP, hPFS and OS.
Trametinib in combination with hydroxychloroquine or palbociclib in advanced metastatic pancreatic cancer: data from a retrospective, multicentric cohort (AIO AIO-TF/PAK-0123)
Authors: Witte David , Pretzell Ina , Reissig Timm M , Stein Alexander , Velthaus Janna-Lisa , Alig Annabel , Bohnenberger Hanibal , Knödler Maren , Kurreck Annika , Sulzer Sabrina , Beyer Georg , Dorman Klara , Fröhlich Tabea , Hegenberg Stefanie , Lugnier Celine , Saborowski Anna , Vogel Arndt , Lange Sebastian , Reichert Maximilian , Flade Franziska , Klaas Lioba , Utpatel Kirsten , Becker Heiko , Bleckmann Annalen , Wethmar Klaus , Reinacher-Schick Anke , Westphalen Christoph Benedikt 
Published: October 2024

Abstract
Background
Preclinical models of pancreatic cancer (PDAC) suggest a synergistic role for combined MEK and autophagy signaling inhibition, as well as MEK and CDK4/6 pathway targeting. Several case reports implicate clinical activity of the combination of either trametinib and hydroxychloroquine (HCQ) in patients with KRAS-mutant PDAC or trametinib with CDK4/6 inhibitors in patients with KRAS and CDKN2A/B alterations. However, prospective data from clinical trials is lacking. Here, we aim to provide clinical evidence regarding the use of these experimental regimens in the setting of dedicated precision oncology programs.

Methods
In this retrospective case series, PDAC patients who received either trametinib/HCQ (THCQ) or trametinib/palbociclib (TP) were retrospectively identified across 11 participating cancer centers in Germany.

Results
Overall, 34 patients were identified. 19 patients received THCQ, and 15 received TP, respectively. In patients treated with THCQ, the median duration of treatment was 46 days, median progression-free survival (PFS) was 52 days and median overall survival (OS) was 68 days. In the THCQ subgroup, all patients evaluable for response (13/19) had progressive disease (PD) within 100 days. In the TP subgroup, the median duration of treatment was 60 days, median PFS was 56 days and median OS was 195 days. In the TP subgroup, 9/15 patients were evaluable for response, of which 1/9 showed a partial response (PR) while 8/9 had PD. One patient achieved a clinical benefit despite progression under TP.

Conclusion
THCQ and TP are not effective in patients with advanced PDAC harboring KRAS mutations or alterations in MAPK/CDKN2A/B.
Integrating palliative care into multiple myeloma management
Authors: Rüsing Lina , Brunbauer Christina , Michel Clara Sophie , Wenzel Claudia , Bauer Philipp , Vospernik Lea , Rabensteiner Julia , Adamidis Feroniki , Baer Joachim , Ecker Franziska , Kum Lea , Agis Hermine , Masel Eva Katharina , Krauth Maria Theresa 
Published: September 2024

Summary
Background
Multiple myeloma (MM) poses significant challenges due to its complex symptomatology and evolving treatment landscape. While therapeutic advances have improved survival outcomes, holistic management of MM requires addressing the numerous physical and psychosocial needs of patients. Palliative care (PC) offers a comprehensive approach to symptom management and supportive care on a physical, psychosocial and spiritual level; however, its role in MM remains underexplored.

Methods
This retrospective single-center study examines the outcome of 22 MM patients admitted to the Division of Palliative Medicine at the Medical University of Vienna. We investigated reasons for admission, symptom severity, functional status, length of stay and overall survival.

Results
Most common reasons for palliative care unit (PCU) admission were nutritional problems (82%), fatigue (77%) and pain (68%). Median ECOG score at PCU admission was 3. The timepoint within the timeline of myeloma disease at which hospitalization took place varied greatly. Some patients were hospitalized shortly after diagnosis, other patients after many years of active disease and therapy. Median time from MM initial diagnosis to first PCU stay was 4.3 years (range 0.6–23.8 years). The median length of hospital (PCU) stay was 11 days (range 1–127days) and 45% of patients died during PCU hospitalization. The reduction in symptom burden as a result of the inpatient stay in the PCU is reflected in the PERS2ON score, which was measured on the day of admission (median 23 days, range 6–32 days) and on the day of discharge (median 16 days, range 7–20 days).

Conclusion
PC interventions effectively addressed the complex symptom burden experienced by patients with MM. Multidimensional approaches encompassing physical, psychological and social domains proved instrumental in optimizing quality of life. Integrating PC principles into MM management paradigms is essential to prioritize patient-centered care across the disease continuum.
Investigating the impact of urban development on the activation of a paleolandslide. A case study from Pissouri, Cyprus
Authors: Tzampoglou Ploutarchos , Loukidis Dimitrios , Karlas Epameinondas , Tolomei Cristiano , Svigkas Nikos , Pezzo Giuseppe , Koulermou Niki , Anastasiades Aristodemos , Loupasakis Constantinos 
Published: October 2024

AbstractThe present study investigates the reactivation of a paleolandslide due to the expansion of a community in an area covered by plastic Pliocene marls in the southwestern part of Cyprus. The landslide, which takes place in an area with gently sloping ground and relatively shallow water table, affects more than 100 residential buildings. In the context of the study, building damages and ground surface ruptures were mapped through field work campaigns. Remote sensing data from InSAR (Interferometric Synthetic Aperture Radar) analysis were evaluated in conjunction with available geological, geotechnical and hydrogeological data. Subsequently, the landslide was backanalyzed using the finite element method to examine possible failure mechanism scenarios and shed light on the influence of potential triggering factors. The results indicate that the paleolandslide has been almost fully reactivated, with the main cause of the reactivation being the rising of the phreatic water table due to long-term discharges of wastewater through the absorption pits of the residential developments. The water table rise was further amplified by rainwater infiltration during rainy years. According to the backanalysis results, the slip surface follows the bedding planes of weak marl horizons with residual friction angle of the order of 10°.
Mitochondrial ribosomal proteins in metastasis and their potential use as prognostic and therapeutic targets
Authors: Bacon Jasmine M. , Jones Johanna L. , Liu Guei-Sheung , Dickinson Joanne L. , Raspin Kelsie 
Published: October 2024

AbstractThe mitochondrion is an essential cell organelle known as the powerhouse of the cell. Mitochondrial ribosomal proteins (MRPs) are nuclear encoded, synthesised in the cytoplasm but perform their main functions in the mitochondria, which includes translation, transcription, cell death and maintenance. However, MRPs have also been implicated in cancer, particularly advanced disease and metastasis across a broad range of cancer types, where they play a central role in cell survival and progression. For some, their altered expression has been investigated as potential prognostic markers, and/or therapeutic targets, which is the focus of this review. Several therapies targeting MRPs are currently approved by the Food and Drug Administration and the European Medicines Agency for use in other diseases, revealing the opportunity for repurposing their use in advanced and metastatic cancer. Herein, we review the evidence supporting key MRPs as molecular drivers of advanced disease in multiple cancer types. We also highlight promising avenues for future use of MRPs as precision targets in the treatment of late-stage cancers for which there are currently very limited effective treatment options.
Chitosan coatings reinforced with cellulose crystals and oregano essential oil as antimicrobial protection against the microbiological contamination of stone sculptures
Authors: Silva Nádia C. , Madureira Ana Raquel , Pintado Manuela , Moreira Patrícia R. 
Published: October 2024

AbstractThe proliferation of microorganisms in outdoor stone sculptures and cultural objects can damage the structure and aesthetics of the materials through biodeterioration mechanisms. Biocides and synthetic products are often used to prevent this phenomenon, despite their negative impact on the environment and human health. Less toxic alternatives with reduced environmental impact can be an option for the preventive conservation of stone sculptures to reduce the environmental impact. In this work, chitosan formulations reinforced with two types of cellulose crystals (microcrystalline cellulose (MCC) or cellulose nanocrystals (CNCs)) and with or without citric acid and sodium tripolyphosphate were prepared. The films obtained with these formulations showed low solubility, and those only containing MCC or CNCs had the lowest wettability. The formulation containing 2% (w/v) MCC was selected for further analysis and supplemented with oregano essential oil (OEO) at 1% (v/v) and 2% (v/v), exhibiting low solubility, swelling and wettability when polymerised in film form. Inoculation of the films with Staphylococcus aureus, Bacillus cereus, Pseudomonas aeruginosa and Rhodotorula spp. resulted in total or partial inhibition of their growth, as well as a 60–100% reduction in Penicillium chrysogenum growth, depending on the concentration of OEO. The formulation with 2% (v/v) OEO was applied to samples of granite, marble and limestone, forming a protective, yet irregular coating on their surfaces. The wettability of the stones’ surfaces was reduced without becoming completely water-repellent and the coating did not cause visible colour changes.
Eye movements in conceptual and non-conceptual thinking
Authors: Solstad Trygve , Kaspersen Eivind , Eggen Magnus 
Published: October 2024

AbstractHow to influence and assess whether students engage in conceptual thinking are longstanding methodological problems in mathematics education. Recently, eye-tracking technology has fueled a discussion on whether eye movement analysis can support valid inferences about mathematical thinking. This study investigates whether eye movement analysis can distinguish between conceptual and non-conceptual thinking in a geometric classification task where both modes of thinking lead to identical responses. Participants were asked to classify geometric shapes while we tracked their eye movements and to report their thinking verbally. Our findings indicate that self-reported conceptual thinking is characterised by fewer eye movements between task shapes and response shapes, and that self-reported non-conceptual thinking involves comparing the shapes’ similarity directly. A logistic regression model correctly classified the self-reported ways of thinking in 80.3% of the cases. We conclude that eye-tracking can contribute to making inferences about mathematical thought processes and facilitate research on how to engage students in conceptual thinking and development.
“I Do Not Believe We Should Disclose Everything to an Older Patient”: Challenges and Ethical Concerns in Clinical Decision-Making in Old-Age Care in Ethiopia
Authors: Mussie Kirubel Manyazewal , Kaba Mirgissa , Setchell Jenny , Elger Bernice Simone 
Published: October 2024

AbstractClinical decision-making in old-age care is a complex and ethically sensitive process. Despite its importance, research addressing the challenges of clinical decision-making in old-age care within this cultural context is limited. This study aimed to explore the challenges and ethical concerns in clinical decision-making in old-age care in Ethiopia. This qualitative study employed an inductive approach with data collected via semi-structured interviews with 20 older patients and 26 health professionals recruited from healthcare facilities in Ethiopia. Data were analysed using reflexive thematic analysis. Our analysis identified three key themes. First, participants highlighted perceptions that older patients’ religious beliefs interfere with the clinical decisions both older patients and health professionals make. Second, older patients often receive limited information from health professionals about their diagnosis and treatment. Third, families of older patients appear to strongly influence clinical decisions made by older patients or health professionals. This research enhances the understanding of clinical decision-making in old-age care within Ethiopia, a context where such research is scarce. As a result, this study contributes towards advancing the deliberation of ethical dilemmas that health professionals who work with older patients in Ethiopia might face. A key implication of the study is that there is a need for more ethics and cultural competence training for health professionals working with older patients in Ethiopia.
Using desiccation-resistant eggs to explore the ecology of giant ostracods (subfamily Mytilocypridinae) in Australian salt lakes
Authors: Rahman Mahabubur , Chaplin Jennifer , Lawrie Angus , Pinder Adrian 
Published: October 2024

Abstract
Giant ostracods in the subfamily Mytilocypridinae are an important component of the biota of Australian salt lakes, which are predominantly temporary, and often located in remote arid areas. Mytilocypridines produce desiccation-resistant eggs to persist in these habitats during unfavourable conditions. In this study, we used mytilocypridine eggs collected from sediments in salt lakes in Western Australia to analyse aspects of the ecology of these ostracods. We conducted two rehydration trials, where sediment was collected from dry lakes or the dry margins of lakes, rehydrated in a laboratory setting, and selected mytilocypridine species hatched and raised in cultures. The first trial found that the eggs of mytilocypridine species were unevenly distributed in a dry lake and could be hatched even after 27 months of dry storage with no discernible loss of viability. The second trial assessed the capacity of selected mytilocypridines to hatch and develop into adults under different salinity treatments. One species, Australocypris insularis, hatched and developed across a very wide salinity range (0–100 g/L). Egg/sediment samples provide a means for testing species’ tolerance to physical and chemical variables throughout their entire life cycle, as well as for surveying the mytilocypridines in remote lakes that rarely hold water.
The Rhetoric of Healthcare and the Moral Debate About Theatre-Funded Hospitals in Early Modern Spain
Authors: Bergman Ted L. L. 
Published: October 2024

AbstractWhile early modern Spain may seem a world away, it is an extremely rich and relevant context for gaining a better understanding of the Rhetoric of Health, specifically the power of metaphor, in the related spheres of policy-making and public debate. It was a time and place in which the urban populace’s physical well-being depended upon the fortunes of theatrical performances due to a system of alms for hospitals driven by ticket receipts. Anti-theatricalists argued that the immoral nature of theatrical performances made them spiritually and medically detrimental to society. Pro-theatricalists argued that plays were always a public good on balance because they raised much-needed funds for hospitals. Instead of producing a conflict between morality and public health, each side reinforced their connection until the two topics became nearly inseparable in the sphere of public debate. While pro-theatricalists mainly stayed with their arguments about funding hospitals, anti-theatricalists developed a new strategy of literalising the metaphor of theatre as a “plague of the republic” and arguing that immoral entertainment brought literal disease to the populace as a punishment from God. This exemplifies Stephen Pender’s observation of how, in an early modern medical context, “Rhetoric as a way of perceiving probabilities and adjusting one’s argument to the audience and circumstance offers a model of ethical action and interaction”. This article is organised chronologically to track specific adjustments to a specific public-health debate that rely upon moral metaphors of medicine. Each side wrangled over these metaphors in an effort to break a deadlock in a public-health policy debate with entertainment, finance, and morality at its centre. By the end of the seventeenth century, anti-theatricalists finally found their best rhetorical weapon in the literalisation of the “plague of the republic” metaphor, but it only offered a short-term solution to banning theatre contingent upon the ebb and flow of epidemics. Simultaneously, the finance structure of funding hospitals began to erase the role of hospitals from the longstanding debate about the morality of public theatre. The case of early modern Spain provides valuable lessons about the power of metaphor in the Rhetoric of Healthcare that are still applicable today.