bluuebunny/crossref_metadata_2025_split huggingface dataset:
Updated breeding distribution and population status of Jankowski’s Bunting Emberiza jankowskii in China
Authors: HAN ZHENG , ZHANG LI-SHI , QIN BO , WANG LIN , LIU YU , FU VIVIAN WING KAN , JIANG YUN-LEI , FU JIANPING , WANG HAI-TAO 
Published: December 2017

SummarySince 2010, Jankowski’s Bunting Emberiza jankowskii has been listed as ‘Endangered’ on the IUCN Red List of Threatened Species. However, because no comprehensive surveys had been conducted, it was not known whether undiscovered populations existed elsewhere, so the population status of the species could not be assessed accurately. The aim of this study was to assess the breeding distribution and population size of Jankowski’s Bunting in China. Fifty sites in Inner Mongolia, and Jilin, Heilongjiang, Liaoning and Hebei Provinces were surveyed to locate suitable habitat and breeding populations of Jankowski’s Bunting. The surveyed sites included historical breeding distribution areas, wintering sites, and regions adjacent to historical breeding distribution areas. We confirmed that Jankowski’s Bunting has disappeared from most of its former breeding distributions, with the exceptions of Dagang, Xiergen and Tumiji. Additionally, 13 new breeding sites were discovered in Inner Mongolia. All currently known populations breed in Mongolian steppe-vegetation zones, with shrubs dominated by the natural Siberian apricot Prunus sibirica, indicating that this type of habitat is crucial for the survival of the species. Based on remote sensing, the suitable breeding habitat for Jankowski’s Bunting is estimated to be approximately 280 km2. The population size of Jankowski’s Bunting could range between 9,800 and 12,500 individuals, which is much higher than the numbers estimated in previous reports that were based on partial surveys. The suitable habitat remaining in Inner Mongolia would highly benefit from the implementation of the National Key Public Forest Protection Project. The population size of Jankowski’s Bunting is larger than previously estimated, but it is still threatened by habitat degradation and fragmentation, and our survey results reinforce the need for more research. The status of Jankowski’s Bunting in China still meets the IUCN criteria B2ab for an ‘Endangered’ species.
Toxicity of marine pollutants on the ascidian oocyte physiology: an electrophysiological approach
Authors: Gallo Alessandra 
Published: December 2017

SummaryIn marine animals with external fertilization, gametes are released into seawater where fertilization and embryo development occur. Consequently, pollutants introduced into the marine environment by human activities may affect gametes and embryos. These xenobiotics can alter cell physiology with consequent reduction of fertilization success. Here the adverse effects on the reproductive processes of the marine invertebrate Ciona intestinalis (ascidian) of different xenobiotics: lead, zinc, an organic tin compound and a phenylurea herbicide were evaluated. By using the electrophysiological technique of whole-cell voltage clamping, the effects of these compounds on the mature oocyte plasma membrane electrical properties and the electrical events of fertilization were tested by calculating the concentration that induced 50% normal larval formation (EC50). The results demonstrated that sodium currents in mature oocytes were reduced in a concentration-dependent manner by all tested xenobiotics, with the lowest EC50 value for lead. In contrast, fertilization current frequencies were differently affected by zinc and organic tin compound. Toxicity tests on gametes demonstrated that sperm fertilizing capability and fertilization oocyte competence were not altered by xenobiotics, whereas fertilization was inhibited in zinc solution and underwent a reduction in organic tin compound solution (EC50 value of 1.7 µM). Furthermore, fertilized oocytes resulted in a low percentage of normal larvae with an EC50 value of 0.90 µM. This study shows that reproductive processes of ascidians are highly sensitive to xenobiotics suggesting that they may be considered a reliable biomarker and that ascidians are suitable model organisms to assess marine environmental quality.
Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform
Authors: Silva Diana Isabel , Santos Bruno Paiva dos , Leng Jacques , Oliveira Hugo , Amédée Joëlle 
Published: December 2017

AbstractInnervation by the sensory nervous system plays a key role in skeletal development and in orchestration of bone remodeling and regeneration. However, it is unclear how and in which bone cells can sensory nerves act to control these processes. Here, we show a microfluidic coculture system comprising dorsal root ganglion (DRG) neurons and mesenchymal stem cells (MSCs) that more faithfully represents the in vivo scenario of bone sensory innervation. We report that DRG neurons promote the osteogenic differentiation capacity of MSCs, by mediating the increase of alkaline phosphatase activity and the upregulation of osteoblast-specific genes. Furthermore, we show that DRG neurons have a positive impact on Cx43 levels in MSCs during osteoblastogenesis, especially at an early stage of this process. Conversely, we described a negative impact of DRG neurons on MSCs N-cadherin expression at a later stage. Finally, we demonstrate a cytoplasmic accumulation of β-catenin translocation into the nucleus, and subsequently Lymphoid Enhancer Binding Factor 1—responsive transcriptional activation of downstream genes in cocultured MSCs. Together, our study provides a robust body of evidence that the direct interaction of DRG neurons with MSCs in a bone-like microenvironment leads to an enhancement of osteoblast differentiation potential of MSCs. The osteogenic effect of DRG neurons on MSCs is mediated through the regulation of Cx43 and N-cadherin expression and activation of the canonical/β-catenin Wnt signaling pathway.
BCL-XL overexpression promotes tumor progression-associated properties
Authors: Trisciuoglio Daniela , Tupone Maria Grazia , Desideri Marianna , Di Martile Marta , Gabellini Chiara , Buglioni Simonetta , Pallocca Matteo , Alessandrini Gabriele , D’Aguanno Simona , Del Bufalo Donatella 
Published: December 2017

AbstractBy using human melanoma and glioblastoma cell lines and their derivative BCL-XL overexpressing clones, we investigated the role of BCL-XL in aggressive features of these two tumor histotypes. We found that in both models, BCL-XL overexpression increased in vitro cell migration and invasion and facilitated tumor cells to form de novo vasculogenic structures. Furthermore, BCL-XL overexpressing cells exhibited higher tumors sphere formation capacity and expressed higher levels of some stem cell markers, supporting the concept that BCL-XL plays essential roles in the maintenance of cancer stem cell phenotype. BCL-XL expression reduction by siRNA, the exposure to a BCL-XL-specific inhibitor and the use of a panel of human melanoma cell lines corroborated the evidence that BCL-XL regulates tumor progression-associated properties. Finally, the vascular markers and the vasculogenic mimicry were up-regulated in the BCL-XL overexpressing xenografts derived from both tumor histotypes. In conclusion, our work brings further support to the understanding of the malignant actions of BCL-XL and, in particular, to the concept that BCL-XL promotes stemness and contributes to the aggressiveness of both melanoma and glioblastoma.
Model-free inference of direct network interactions from nonlinear collective dynamics
Authors: Casadiego Jose , Nitzan Mor , Hallerberg Sarah , Timme Marc 
Published: December 2017

AbstractThe topology of interactions in network dynamical systems fundamentally underlies their function. Accelerating technological progress creates massively available data about collective nonlinear dynamics in physical, biological, and technological systems. Detecting direct interaction patterns from those dynamics still constitutes a major open problem. In particular, current nonlinear dynamics approaches mostly require to know a priori a model of the (often high dimensional) system dynamics. Here we develop a model-independent framework for inferring direct interactions solely from recording the nonlinear collective dynamics generated. Introducing an explicit dependency matrix in combination with a block-orthogonal regression algorithm, the approach works reliably across many dynamical regimes, including transient dynamics toward steady states, periodic and non-periodic dynamics, and chaos. Together with its capabilities to reveal network (two point) as well as hypernetwork (e.g., three point) interactions, this framework may thus open up nonlinear dynamics options of inferring direct interaction patterns across systems where no model is known.
Inhaled nitrous oxide can reduce the pain perception in post Caldwell-Luc operation patients–a randomised trial
Authors: Dong Ting , Liu Mingwen , Lv Kun 
Published: December 2017

AbstractTo assess the efficiency of inhaled nitrous oxide (N2O) for the reduce the perception pain in extraction of iodoform gauze packing strips in post Caldwell-Luc operation patients. This randomized single blind trial included a total of 47 patients, aged between 14–82 years, in which undergoing radical maxillary sinusotomy. Based on the randomization procedure, patients were treated with (experimental) or without (control) inhaled N2O. The visual analogue scale scores (VAS scores) of the pain perception and the headache duration time were comparatively studied. The average VAS score for pain perception was 3.92 in the N2O group and 7.87 in the control group. The average headache duration time was 0.12 hour in the N2O group and 13.09 hours in the control group. Both VAS scores for pain perception during the treatment and the average headache duration time were significantly reduced in the inhaled N2O group (P < 0.01). Reduced pain perception and headache duration time indicated that, the inhaled N2O method might be viable in extraction of iodoform gauze packing strips in post Caldwell-Luc operation patients.
Associations of genetic polymorphisms in pTEN/AKT/mTOR signaling pathway genes with cancer risk: A meta-analysis in Asian population
Authors: Zhang Zhen , Chen Qiuchen , Zhang Jing , Wang Yilin , Hu Xiaoyun , Yin Sainan , He Miao , Guan Shu , Qin Wenyan , Xiao Qinghuan , Zhao Haishan , Yao Weifan , Wu Huizhe , Wei Minjie 
Published: December 2017

AbstractThe pTEN/AKT/mTOR signaling pathways play a critical role in balancing cell proliferation, differentiation, and survival. Recent studies researched the associations of core genes in the pTEN/AKT/mTOR pathway polymorphisms with the cancer susceptibility; however, the results are inconclusive. Therefore, a systematically meta-analysis was performed to evaluate the association between the five SNPs (mTOR rs2295080 and rs2536, AKT1 rs2494750 and rs2494752, pTEN rs701848) and cancer risk by systematic review of the literature in 31 eligible studies. The results showed a significant decreased risk between rs2295080 TG, GG genotype, and GG/TG genotypes and overall cancer [TG vs.TT: OR(95% CI) = 0.82(0.76, 0.89), GG/TG vs. TT: OR(95% CI) = 0.82(0.76, 0.88), and GG vs. TG/TT: OR(95% CI) = 0.67(0.51, 0.88)] and the subgroup of urinary system cancer and digestive system cancer. Moreover, the SNP rs701848 CC, TC genotype showed significantly increased the overall cancer risk both in dominant model [CC/TC vs. TT: OR(95% CI) = 1.25(1.15, 1.36)] and recessive model [CC vs. TC/TT: OR(95% CI) = 1.20(1.09, 1.32)], and digestive system cancer and urinary system cancer. In addition, AG genotype and GG/AG genotype of rs2494752 was associated with increased risk of cancer. Therefore, this meta-analysis provided genetic risk factors for carcinogenesis and the most valid cancer prevalence estimate for Asian population.
NLRP3 inflammasome is a key player in human vulvovaginal disease caused by Candida albicans
Authors: Roselletti Elena , Perito Stefano , Gabrielli Elena , Mencacci Antonella , Pericolini Eva , Sabbatini Samuele , Cassone Antonio , Vecchiarelli Anna 
Published: December 2017

AbstractThe expression of host inflammatory and Candida albicans putative virulence factors was studied in women with vulvovaginal candidiasis (VVC; twenty) or colonized by the fungus but asymptomatic (carriers; fifteen) or non-colonized asymptomatic (ten subjects). Overexpression of genes encoding NLRP3 and caspase-1 inflammasome components sharply differentiated VVC patients from asymptomatic colonized or non-colonized women. Inflammasome expression was coupled with neutrophils recruitment in the vagina of VVC women and IL-1β and IL-8 production. Both cytokines were present, though to a lower concentration, also in the vaginal fluid of colonized and non-colonized women. Secretory aspartyl proteinases (SAPs) and hyphae associated genes HWP1 and ECE1 were upregulated in VVC but with some differences among infected women. The most overexpressed SAP gene was SAP2, that correlated with neutrophils accumulation. Our data provide clinical evidence that the intracytoplasmic activation of NLRP3 inflammasome complex plays a critical, pathogenesis-relevant role in human VVC.
Films of Bacteria at Interfaces (FBI): Remodeling of Fluid Interfaces by Pseudomonas aeruginosa
Authors: Niepa Tagbo H. R. , Vaccari Liana , Leheny Robert L. , Goulian Mark , Lee Daeyeon , Stebe Kathleen J. 
Published: December 2017

AbstractBacteria at fluid interfaces endure physical and chemical stresses unique to these highly asymmetric environments. The responses of Pseudomonas aeruginosa PAO1 and PA14 to a hexadecane-water interface are compared. PAO1 cells form elastic films of bacteria, excreted polysaccharides and proteins, whereas PA14 cells move actively without forming an elastic film. Studies of PAO1 mutants show that, unlike solid-supported biofilms, elastic interfacial film formation occurs in the absence of flagella, pili, or certain polysaccharides. Highly induced genes identified in transcriptional profiling include those for putative enzymes and a carbohydrate metabolism enzyme, alkB2; this latter gene is not upregulated in PA14 cells. Notably, PAO1 mutants lacking the alkB2 gene fail to form an elastic layer. Rather, they form an active film like that formed by PA14. These findings demonstrate that genetic expression is altered by interfacial confinement, and suggest that the ability to metabolize alkanes may play a role in elastic film formation at oil-water interfaces.
Skyrmion electrical detection with the use of three-dimensional Topological Insulators/Ferromagnetic bilayers
Authors: Andrikopoulos Dimitrios , Sorée Bart 
Published: December 2017

AbstractThe effect of the magnetic skyrmion texture on the electronic transport properties of the TI surface state coupled to a thin-film FM is numerically investigated. It is shown that both Bloch (vortex) and Néel (hedgehog) skyrmion textures induce additional scattering on top of a homogeneous background FM texture which can modify the conductance of the system. The change in conductance depends on several factors including the skyrmion size, the dimensions of the FM and the exchange interaction strength. For the Néel skyrmion, the result of the interaction strongly depends on the skyrmion number N
sk
and the skyrmion helicity h. For both skyrmion types, significant change of the resistance can be achieved, which is in the order of kΩ.
Hemographic indices are associated with mortality in acute heart failure
Authors: Huang Wei-Ming , Cheng Hao-Min , Huang Chi-Jung , Guo Chao-Yu , Lu Dai-Yin , Lee Ching-Wei , Hsu Pai-Feng , Yu Wen-Chung , Chen Chen-Huan , Sung Shih-Hsien 
Published: December 2017

AbstractHemographic indices have been associated with clinical outcomes in patients with chronic heart failure. We therefore investigated the prognostic values of hemographic indices in patients hospitalized for acute heart failure (AHF). Patients hospitalized primarily for AHF were drawn from an intramural registry. Hemographic indices, including white blood cell counts, neutrophil counts, neutrophil-to-lymphocyte ratio, reciprocal of lymphocyte (RL) and platelet-to-lymphocyte ratio were recorded. Among a total of 1923 participants (mean age 76 ± 12 years, 68% men), 875 patients died during a mean follow-up of 28.6 ± 20.7 months. Except for white blood cell counts, all the other hemographic indices were related to mortality, independently. In a forward stepwise Cox regression analysis among hemographic indices, RL was the strongest predictor (HR and 95% CI per-1SD:1.166,1.097–1.240) for mortality, after accounting for confounders. However, conditioned on the survivals, the hemographic indices were independently related to mortality within 3 years of follow-up, rather than beyond. Hemographic indices were independent risk factors of mortality in patients hospitalized for AHF, especially in patients with impaired left ventricular systolic function. As an acute presentation of inflammation, hemographic indices might be useful to identify subjects at risk of mortality soon after the index hospitalization.
Factors influencing neurocognitive function in patients with neuroepithelial tumors
Authors: Gempt Jens , Lange Nicole , Bette Stefanie , Foreman Sarah Charlotte , Cammardella Jasmin Hernandez , Albertshauser Jennifer , Gradtke Corinna , Buchmann Niels , Ryang Yu-Mi , Schmidt-Graf Friederike , Meyer Bernhard , Ringel Florian 
Published: December 2017

AbstractThough cognitive function is proven to be an independent predictor of survival in patients with intrinsic brain tumors, cognitive functions are still rarely considered. Aim of this study was to assess neurocognitive function and to identify risk factors for neurocognitive deficits. 103 patients with primary neuroepithelial tumors who received tumor resections or biopsies were included in this prospective study. The following data was acquired: mini-mental state examination, preoperative tumor volume, WHO grade, tumor entity and location, and the Karnofsky performance status scale. Furthermore, patients participated in extensive neuropsychological testing of attentional, memory and executive functions. General factors like age, clinical status, WHO grade, tumor volume and tumor location correlated with patients’ neurocognitive functions. Affection of the parietal lobe resulted in significant impairment of attention and memory functions. Frontal lobe involvement significantly affected patients’ abilities in planning complex actions and novel problem solving. Patients with temporal lesions were more likely to have impaired memory and executive functions. Comparing results among neuroepithelial tumor patients enables the identification of risk factors for cognitive impairment. General parameters such as age, KPS score, tumor size, and WHO grade are apart from the respective tumor location of high importance for neurocognitive function.
GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity
Authors: Menon Deepthi , Innes Ashlee , Oakley Aaron J. , Dahlstrom Jane E. , Jensen Lora M. , Brüstle Anne , Tummala Padmaja , Rooke Melissa , Casarotto Marco G. , Baell Jonathan B. , Nguyen Nghi , Xie Yiyue , Cuellar Matthew , Strasser Jessica , Dahlin Jayme L. , Walters Michael A. , Burgio Gaetan , O’Neill Luke A. J. , Board Philip G. 
Published: December 2017

AbstractGlutathione transferase Omega 1 (GSTO1-1) is an atypical GST reported to play a pro-inflammatory role in response to LPS. Here we show that genetic knockout ofGsto1alters the response of mice to three distinct inflammatory disease models. GSTO1-1 deficiency ameliorates the inflammatory response stimulated by LPS and attenuates the inflammatory impact of a high fat diet on glucose tolerance and insulin resistance. In contrast, GSTO1-1 deficient mice show a more severe inflammatory response and increased escape of bacteria from the colon into the lymphatic system in a dextran sodium sulfate mediated model of inflammatory bowel disease. These responses are similar to those of TLR4 and MyD88 deficient mice in these models and confirm that GSTO1-1 is critical for a TLR4-like pro-inflammatory responsein vivo. In wild-type mice, we show that a small molecule inhibitor that covalently binds in the active site of GSTO1-1 can be used to ameliorate the inflammatory response to LPS. Our findings demonstrate the potential therapeutic utility of GSTO1-1 inhibitors in the modulation of inflammation and suggest their possible application in the treatment of a range of inflammatory conditions.
High Energy Density in Azobenzene-based Materials for Photo-Thermal Batteries via Controlled Polymer Architecture and Polymer-Solvent Interactions
Authors: Jeong Seung Pyo , Renna Lawrence A. , Boyle Connor J. , Kwak Hyunwook S. , Harder Edward , Damm Wolfgang , Venkataraman Dhandapani 
Published: December 2017

AbstractEnergy densities of ~510 J/g (max: 698 J/g) have been achieved in azobenzene-based syndiotactic-rich poly(methacrylate) polymers. The processing solvent and polymer-solvent interactions are important to achieve morphologically optimal structures for high-energy density materials. This work shows that morphological changes of solid-state syndiotactic polymers, driven by different solvent processings play an important role in controlling the activation energy of Z-E isomerization as well as the shape of the DSC exotherm. Thus, this study shows the crucial role of processing solvents and thin film structure in achieving higher energy densities.
Efficient Direct Formic Acid Fuel Cells (DFAFCs) Anode Derived from Seafood waste: Migration Mechanism
Authors: El-Nagar Gumaa A. , Hassan Mohamed A. , Lauermann Iver , Roth Christina 
Published: December 2017

AbstractCommercial Pt/C anodes of direct formic acid fuel cells (DFAFCs) get rapidly poisoned by in-situ generated CO intermediates from formic acid non-faradaic dissociation. We succeeded in increasing the Pt nanoparticles (PtNPs) stability and activity for formic acid oxidation (DFAFCs anodic reaction) by embedding them inside a chitosan matrix obtained from seafood wastes. Atop the commercial Pt/C, formic acid (FA) is predominantly oxidized via the undesired poisoning dehydration pathway (14 times higher than the desired dehydrogenation route), wherein FA is non-faradaically dissociated to CO resulting in deactivation of the majority of the Pt active-surface sites. Surprisingly, PtNPs chemical insertion inside a chitosan matrix enhanced their efficiency for FA oxidation significantly, as demonstrated by their 27 times higher stability along with ~400 mV negative shift of the FA oxidation onset potential together with 270 times higher CO poisoning-tolerance compared to that of the commercial Pt/C. These substantial performance enhancements are believed to originate from the interaction of chitosan functionalities (e.g., NH2 and OH) with both PtNPs and FA molecules improving FA adsorption and preventing the PtNPs aggregation, besides providing the required oxygen helping with the oxidative removal of the adsorbed poisoning CO-like species at low potentials. Additionally, chitosan induced the retrieval of the Pt surface-active sites by capturing the in-situ formed poisoning CO intermediates via a so-called “migration mechanism”.