bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Late-Antique (ca. 200–800 A.D.) Prolegomena to Aristotle’s Categories on Arabic Doctrines of the Subject Matter of Logic: Alfarabi (d. ca. 950 A.D.), Baghdad Peripatetics, Avicenna (d. 1037 A.D.)
Authors: Karimullah Kamran I. 
Published: September 2017

Abstract:In this article, I explore how Avicenna’s (d. 1037) views about the subject matter of logic relate to earlier debates about Aristotle’s Categories among Aristotle’s Platonist commentators and the Baghdad Peripatetics, chief among them being Alfarabi (d. ca. 950). I argue that Alfarabi invents the idea of secondary intelligibles (or “second intentions”). I show, however, that under the influence of the middle and late Platonist commentary tradition on the Categories, he insists that primary intelligibles, not secondary intelligibles, are the subject matter of logic. While Avicenna thus takes over the idea of secondary intelligibles from Alfarabi, I show that Avicenna rejects Alfarabi’s view that primary intelligibles are the subject matter of logic. I conclude that what motivated Avicenna to hold that secondary intelligibles are the subject matter of logic was his belief that logic is a discipline of philosophy and not merely an instrument of it.
‘Archetypes without Patterns’: Locke on Relations and Mixed Modes
Authors: Ott Walter 
Published: September 2017

Abstract:John Locke’s claims about relations (such as cause and effect) and mixed modes (such as beauty and murder) have been controversial since the publication of theEssay. His earliest critics read him as a thoroughgoing anti-realist who denies that such things exist. More charitable readers have sought to read Locke’s claims away. Against both, I argue that Locke is making ontological claims, but that his views do not have the absurd consequences his defenders fear. By examining Locke’s texts, as well as the intellectual context in which they were written, I show that Locke’s position is at once radical and thoroughly traditional.
A selective fluorescence probe based on benzothiazole for the detection of Cr3+
Authors: Lv Ren-Gang , Chen Shu-Wen , Gao Yan 
Published: September 2017

Abstract
A novel benzothiazole-functionalized Schiff-base derivative L was prepared and its metal-ion sensing properties were investigated. Sensor L displays selective naked-eye color change from yellow to green in the presence of Cr3+ in aqueous solution at pH 7.2, while other cations do not interfere with the recognition of Cr3+. The proposed mechanism is supported by Job’s plot evaluation, IR and ESI-MS studies. The association constant and detection limit of sensor L to Cr3+ are 5.73×104
m
−1 and 2.1×10−8
m, respectively. A B3LYP/6-31G (d,p) basis set was employed for optimization of L and L-Cr3+ complex.
Combining Wavelet Texture Features and Deep Neural Network for Tumor Detection and Segmentation Over MRI
Authors: Preethi Srinivasalu , Aishwarya Palaniappan 
Published: September 2017

Abstract
A brain tumor is one of the main reasons for death among other kinds of cancer because the brain is a very sensitive, complex, and central portion of the body. Proper and timely diagnosis can prolong the life of a person to some extent. Consequently, in this paper, we have proposed a brain tumor classification scheme on the basis of combining wavelet texture features and deep neural networks (DNNs). Normally, the system comprises four modules: (i) feature extraction, (ii) feature selection, (iii) tumor classification, and (iv) segmentation. Primarily, we eliminate the noise from the image. Then, the feature matrix is produced by combining wavelet texture features [gray-level co-occurrence matrix (GLCM)+wavelet GLCM]. Following that, we select the relevant features with the help of the oppositional flower pollination algorithm (OFPA) because a high number of features are major obstacles for classification. Then, we categorize the brain image based on the selected features using the DNN. After the classification procedure, the projected scheme extracts the tumor region from the tumor images with the help of the possibilistic fuzzy c-means clustering (PFCM) algorithm. The experimentation results show that the proposed system attains the better result associated with the available methods.
Lascaux oder Die Geburt der Ethik
Authors: Rauer Constantin 
Published: September 2017

Zusammenfassung:Lascaux gehört zu den ältesten Kultstätten der Menschheit und ist zugleich auch die Steinzeithöhle mit den meisten und sicherlich auch schönsten Malereien. Unter den etwa 2.000 Darstellungen befinden sich Bildgeschichten von mythischen Glaubensvorstellungen, Beschreibungen von Kulthandlungen sowie Bilder von ethischen Grundsätzen, die in diesem Beitrag analysiert werden sollen. Alsdann wird versucht, vermittels einer ikonografischen Entschlüsselung der mythischen, kultischen und ethischen Darstellungen die Urreligion der Steinzeit zu rekonstruieren. Dabei wird deutlich, dass Lascaux nach einem präzisen Plan gestaltet wurde, der das Leben im Ost-West-Gang und den Tod im Nord-Süd-Gang bipolar gegenüberstellt. Im Todesgang befinden sich auch die drei einzigen Menschen-Darstellungen der Höhle: zwei Magier (Steinzeitpriester) in der Apsis und im Schacht ein Jäger, der von einer Bisonkuh getötet wird. Die Magier inszenieren eine Magie der Wiedergeburt, die Menschen und Tieren zu einer Wiederauferstehung verhelfen soll. Einige blieben von dieser Magie allerdings ausgeschlossen: jene Jäger nämlich, die sich bei der Jagd falsch verhalten haben und dafür im Schacht, dem wohl ältesten Gefängnis der Menschheit, büßen mussten. Dort saßen sie vor der berühmten Schachtszene mit dem sterbenden Jäger, einem Gemälde, das ihnen die ethischen Grundsätze der Jagd eindringlich vor Augen führte.
Zu den germanischen Gesellschaftsstrukturen an der Unterelbe. Neue Untersuchungen der älterkaiserzeitlichen Gräberfelder von Hamburg-Langenbek und Hamburg-Marmstorf
Authors: Gupte O. , Reiss-Gupte J. 
Published: September 2017

Zusammenfassung:In der vorliegenden Untersuchung wurden die Gesellschaftsstrukturen von Sozietäten an der unteren Elbe am Beispiel der beiden benachbarten Gräberfelder von Hamburg-Langenbek und Hamburg-Marmstorf analysiert, die in ihrer kaiserzeitlichen Phase etwa von Christi Geburt bis in das erste Drittel des 2. Jahrhunderts belegt wurden. Darüber hinaus fanden detaillierte Untersuchungen zum in Hamburg-Marmstorf auftretenden römischen Import statt, deren Ergebnisse eine Neueinschätzung der einzelnen Importfunde erlauben, nicht zuletzt auch im Gesamtkontext beider Gräberfelder.
Evaluation of clinical chemistry tests in emergency laboratory by sigma metrics
Authors: Bozkaya Giray , Aksit Murat , Zeytinli Aksit Merve 
Published: September 2017

Abstract

Aim
Emergency department laboratories, besides from giving accurate results, should be quick enough in order not to delay patient care. Giving fast results doesn’t mean to ignore quality, rather it should always be improved to prevent erroneous results. Six sigma is a modern assessment of quality which is used to determine the analytical performance. Our aim was to evaluate the analytical performance of clinical chemistry tests in our emergency department laboratory by using sigma metrics.

Materials and methods
Our study was performed by using the internal and external quality assessment data of 13 clinical chemistry tests of emergency laboratory. Sigma levels were calculated using bias, coefficient of variation and total allowable error (TEa) ratios of CLIA, Ricos, Rilibak and Turkey.

Results
Sigma levels of various tests (CK, amylase, ALT, AST, urea, creatinine, total bilirubin, sodium and chloride) were found to be ≥6 according to different TEa’s, whereas the performance of sodium, potassium and chloride were unsatisfactory, according to TEa’s of CLIA, Ricos and Rilibak.

Conclusion
Since most of our sigma values were found to be over 3, the analytical performance of clinical chemistry tests was thought to be acceptable and our laboratory can be regarded as a qualified emergency laboratory.
Aberrant Cortical Activity in Multiple GCaMP6-Expressing Transgenic Mouse Lines
Authors: Steinmetz Nicholas A. , Buetfering Christina , Lecoq Jerome , Lee Christian R. , Peters Andrew J. , Jacobs Elina A. K. , Coen Philip , Ollerenshaw Douglas R. , Valley Matthew T. , de Vries Saskia E. J. , Garrett Marina , Zhuang Jun , Groblewski Peter A. , Manavi Sahar , Miles Jesse , White Casey , Lee Eric , Griffin Fiona , Larkin Joshua D. , Roll Kate , Cross Sissy , Nguyen Thuyanh V. , Larsen Rachael , Pendergraft Julie , Daigle Tanya , Tasic Bosiljka , Thompson Carol L. , Waters Jack , Olsen Shawn , Margolis David J. , Zeng Hongkui , Hausser Michael , Carandini Matteo , Harris Kenneth D. 
Published: September 2017

AbstractTransgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the system under study. Here we report aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6 genetically encoded calcium sensors. These epileptiform events have been observed particularly, but not exclusively, in mice with Emx1-Cre and Ai93 transgenes, of either sex, across multiple laboratories. The events occur at >0.1 Hz, are very large in amplitude (>1.0 mV local field potentials, >10% df/f widefield imaging signals), and typically cover large regions of cortex. Many properties of neuronal responses and behavior seem normal despite these events, although rare subjects exhibit overt generalized seizures. The underlying mechanisms of this phenomenon remain unclear, but we speculate about possible causes on the basis of diverse observations. We encourage researchers to be aware of these activity patterns while interpreting neuronal recordings from affected mouse lines and when considering which lines to study.
Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation
Authors: Jiang Wei , Wei Mengping , Liu Mengna , Pan Yunlong , Cao Dong , Yang Xiaofei , Zhang Chen 
Published: September 2017

The proper formation of synapses—specialized unitary structures formed between two neurons—is critical to mediating information flow in the brain. Synaptic cell adhesion molecules (CAMs) are thought to participate in the initiation of the synapse formation process. However,in vivofunctional analysis demonstrates that most well known synaptic CAMs regulate synaptic maturation and plasticity rather than synapse formation, suggesting that either CAMs work synergistically in the process of forming synapses or more CAMs remain to be found. By screening for unknown CAMs using a co-culture system, we revealed that protein tyrosine phosphatase receptor type O (PTPRO) is a potent CAM that induces the formation of artificial synapse clusters in co-cultures of human embryonic kidney 293 cells and hippocampal neurons cultured from newborn mice regardless of gender. PTPRO was enriched in the mouse brain and localized to postsynaptic sites at excitatory synapses. The overexpression of PTPRO in cultured hippocampal neurons increased the number of synapses and the frequency of miniature EPSCs (mEPSCs). The knock-down (KD) of PTPRO expression in cultured neurons by short hairpin RNA (shRNA) reduced the number of synapses and the frequencies of the mEPSCs. The effects of shRNA KD were rescued by expressing either full-length PTPRO or a truncated PTPRO lacking the cytoplasmic domain. Consistent with these results, the N-terminal extracellular domain of PTPRO was required for its synaptogenic activity in the co-culture assay. Our data show that PTPRO is a synaptic CAM that serves as a potent initiator of the formation of excitatory synapses.SIGNIFICANCE STATEMENTThe formation of synapses is critical for the brain to execute its function and synaptic cell adhesion molecules (CAMs) play essential roles in initiating the formation of synapses. By screening for unknown CAMs using a co-culture system, we revealed that protein tyrosine phosphatase receptor type O (PTPRO) is a potent CAM that induces the formation of artificial synapse clusters. Using loss-of-function and gain-of-function approaches, we show that PTPRO promotes the formation of excitatory synapses. The N-terminal extracellular domain of PTPRO was required for its synaptogenic activity in cultured hippocampal neurons and the co-culture assay. Together, our data show that PTPRO is a synaptic CAM that serves as a potent initiator of synapse formation.
Optimal follow-up strategies for adrenal incidentalomas: reappraisal of the 2016 ESE-ENSAT guidelines in real clinical practice
Authors: Hong A Ram , Kim Jung Hee , Park Kyeong Seon , Kim Kyong Young , Lee Ji Hyun , Kong Sung Hye , Lee Seo Young , Shin Chan Soo , Kim Sang Wan , Kim Seong Yeon 
Published: September 2017

Objective
Recently, the European Society of Endocrinology (ESE), in collaboration with the European Network for the Study of Adrenal Tumors (ENSAT), asserted that adrenal incidentalomas (AIs) <4 cm and ≤10 Hounsfield units (HU) do not require further follow-up imaging. To validate the clinical application of the follow-up strategies suggested by the 2016 ESE-ENSAT guidelines, we explored the clinical characteristics and natural course of AIs in a single center over 13 years.

Design and methods
This retrospective cohort study included a total of 1149 patients diagnosed with AIs between 2000 and 2013 in a single tertiary center. Hormonal examination and radiological evaluations were performed at the initial diagnosis of AI and during the follow-up according to the appropriate guidelines.

Results
The mean age at diagnosis was 54.2 years, and the majority of AIs (68.0%) were nonfunctional lesions. Receiver operating curve analysis was used to discriminate malignant from benign lesions; the optimal cut-off value for mass size was 3.4 cm (sensitivity: 100%; specificity: 95.0%), and that for the pre-contrast HU was 19.9 (sensitivity: 100%; specificity: 67.4%). The majority of nonfunctional lesions did not change in size during the 4-year follow-up period. Applying a cut-off value of 1.8 μg/dL after a 1-mg overnight dexamethasone suppression test, 28.0% of all nonfunctional AIs progressed to autonomous cortisol secretion during the follow-up period. However, we observed no development of overt Cushing’s syndrome in the study.

Conclusions
We advocate that no follow-up imaging is required if the detected adrenal mass is <4 cm and has clear benign features. However, prospective studies with longer follow-up are needed to confirm the appropriate follow-up strategies.
Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research
Authors: Wangler Michael F , Yamamoto Shinya , Chao Hsiao-Tuan , Posey Jennifer E , Westerfield Monte , Postlethwait John ,   Members of the Undiagnosed Diseases Network (UDN), Hieter Philip , Boycott Kym M , Campeau Philippe M , Bellen Hugo J 
Published: September 2017

AbstractEfforts to identify the genetic underpinnings of rare undiagnosed diseases increasingly involve the use of next-generation sequencing and comparative genomic hybridization methods. These efforts are limited by a lack of knowledge regarding gene function, and an inability to predict the impact of genetic variation on the encoded protein function. Diagnostic challenges posed by undiagnosed diseases have solutions in model organism research, which provides a wealth of detailed biological information. Model organism geneticists are by necessity experts in particular genes, gene families, specific organs, and biological functions. Here, we review the current state of research into undiagnosed diseases, highlighting large efforts in North America and internationally, including the Undiagnosed Diseases Network (UDN) (Supplemental Material, File S1) and UDN International (UDNI), the Centers for Mendelian Genomics (CMG), and the Canadian Rare Diseases Models and Mechanisms Network (RDMM). We discuss how merging human genetics with model organism research guides experimental studies to solve these medical mysteries, gain new insights into disease pathogenesis, and uncover new therapeutic strategies.
Effectiveness and Safety of Golimumab in Treating Outpatient Ulcerative Colitis: A Real-Life Prospective, Multicentre, Observational Study in Primary Inflammatory Bowel Diseases Centers
Authors: Tursi Antonio , Allegretta Leonardo , Buccianti Nello , Della Valle Nicola , Elisei Walter , Forti Giacomo , Faggiani Roberto , Gallina Sara , Hadad Yusef , Larussa Tiziana , Lauria Angelo , Luzza Francesco , Lorenzetti Roberto , Mocci Giammarco , Penna Antonio , Polimeni Natale , Pranzo Giuseppe , Ricciardelli Cristina , Zampaletta Costantino , Picchio Marcello 
Published: September 2017

Background & Aims: Golimumab (GOL) has been recently approved in Italy for the treatment of ulcerative colitis (UC) unresponsive to standard treatments. Our aims were to assess the real-life efficacy and safety of GOL in managing UC outpatients in Italian primary Inflammatory Bowel Diseases (IBD) centres.Methods: Consecutive UC outpatients with at least 3-months follow-up were enrolled. Primary end-point was the induction and maintenance of remission in UC, defined as Mayo score ≤2, at 6-month follow-up.Results: Ninety-three patients were enrolled. At 6-month follow-up, remission was obtained in 34 (36.5%) patients. Shorter duration of disease was the only significant predictive factor of remission. Clinical response was achieved in 60 (64.5%) patients, while mucosal healing (MH) was obtained in 18 (19.3%) patients. Sixteen (47.0%) patients under remission were still under therapy with steroids. C-reactive protein and fecal calprotectin significantly dropped during the follow-up (p<0.001 for both proteins). Adverse events occurred in 4 (4.3%) patients and 3 of them stopped treatment. Colectomy was performed in only one patient (1.1%).Conclusions: Golimumab seems to be safe and effective in inducing and maintaining remission in real life UC outpatients.Abbreviations: ADA: Adalimumab; CRP: C-reactive Protein; GOL: Golimumab; FC: Fecal calprotectin; IBD: Inflammatory Bowel Diseases; IFX: Infliximab; IQR: Interquartile range; MH: Mucosal Healing; SC: Subcutaneously; TBC: Tuberculosis; TNFα: Tumor necrosis factor α; UC: Ulcerative Colitis.
Bismuth-based Quadruple Therapy Following H. pylori Eradication Failures: a Multicenter Study in Clinical Practice
Authors: Zullo Angelo , De Francesco Vincenzo , Bellesia Annamaria , Vassallo Roberto , D’Angelo Audenzio , Scaccianoce Giuseppe , Sacco Rodolfo , Bresci Giampaolo , Eramo Annarita , Tanzilli Anna , Ridola Lorenzo , Alvaro Domenico , Londoni Claudio , Brambilla Gianfranco , Manta Raffaele , Di Ciaula Agostino , Portincasa Piero 
Published: September 2017

Background & Aims: Helicobacter pylori (H. pylori) eradication in patients who failed one or more therapeutic attempts remains challenging. This study aimed to assess the efficacy of three-in-one capsules bismuth-based quadruple therapy (Pylera®) in these patients managed in clinical practice.
Methods: This was a prospective, open-label, multicenter study enrolling consecutive, adult patients with persistent H. pylori infection following at least one standard therapy. All patients received a rescue quadruple therapy with Pylera (3 capsules four times daily) and esomeprazole 20 mg (1 tablet twice daily) for 10 days. H. pylori eradication was assessed by using Urea Breath Test 4-6 weeks following therapy ending. H. pylori eradication rates, compliance, and side-effects were calculated.
Results: A total of 208 patients in the 9 participating centres were enrolled. Overall, 180 patients were successfully cured from the infection, accounting for 86.5% (95% CI 81.9-91.2) and 92.3% (95% CI 88.6-96.1) eradication rates at intention-to-treat analysis and at per protocol analysis, respectively. Cure rates were similar across patients who failed one to three previous therapy attempts, but the success rate fell to 67% after 4 or more therapy failures. Compliance to therapy was good in 198 (95.2%) patients, whilst in 7 (5.3%) cases the therapy was interrupted within 5 days due to side effects. A total of 97 (46.6%) patients complained of at least one side effect; nausea, diarrhea and vomiting were the most frequently reported.
Conclusions: Our study found that this bismuth-based quadruple therapy is highly effective as second-line and rescue therapy for H. pylori eradication in clinical practice.
Abbreviations: CI: confidence intervals; ITT: intention-to-treat; PP: per protocol; UBT: urea breath test.
A travessia do tempo: a encenação da ambiguidade e a (im)possibilidade da ancestralidade em O outro pé da sereia, de Mia Couto
Authors: Alavarce Camila Silva , Martins Gisele Pimentel 
Published: September 2017

O presente estudo tem como foco analisar como, no projeto literário de Mia Couto, em O outro pé da sereia, há a problematização do tempo e da ancestralidade a partir da construção estética do espaço. Há, no romance, especificamente no capítulo “A travessia do tempo”, metáforas capazes de sugerir a encenação dos embates, e das rasuras deles decorrentes, provocados pela reencenação de rituais antigos no seio da família Rodrigues. Tais rasuras são explicitadas a partir de situações bastante ambíguas experimentadas pelas personagens centrais do romance, Constança e Mwadia, mãe e filha, no interior da casa materna, espaço privilegiado para servir de palco aos mais ambíguos embates. Situação esta que metaforiza a condição atual de Moçambique. Para sustentar este estudo, foram utilizados os estudiosos Assman, Halbwachs,Gama-Khalil, Bhabha, Braúna e Bachelard.********************************************************************The crossing time: the staging of ambiguity and the (im)possibility of ancestry in O outro pé da sereia, by Mia CoutoAbstract: This study focuses on the analysis of how, the literary project of Mia Couto, in O Outro Pé da Sereia, there is a questioning of time and ancestry from the aesthetic construction of space. There are, in the novel, specifically in Chapter “A travessia do tempo”, metaphors able to suggest the scenario of conflicts, and their erasures arising, caused by the restaging of ancient rituals in the family Rodrigues. Such erasures are made explicit from quite ambiguous situations experienced by the main characters of the novel, Constance and Mwadia, mother and daughter, inside the mother’s house, privileged space to serve as a stage to the more ambiguous conflicts. Situation that metaphorizes the current condition of Mozambique. To support this study, the works of Assman, Gamma-Khalil, Bhabha, Braunstone and Bachelard were used.Keyword: Ancestry; Ambiguity; Space; Time; Mia Couto