bluuebunny/crossref_metadata_2025_split huggingface dataset:
B Cells Influence Encephalitogenic T Cell Frequency to Myelin Oligodendrocyte Glycoprotein (MOG)38–49 during Full-length MOG Protein–Induced Demyelinating Disease
Authors: Faust Michael A , Gibbs Lisa , Oviedo Juan M , Cornwall Douglas H , Fairfax Keke C , Zhou Zemin , Lamb Tracey J , Evavold Brian D 
Published: September 2024

Abstract
Although T cells are encephalitogenic during demyelinating disease, B cell–depleting therapies are a successful treatment for patients with multiple sclerosis. Murine models of demyelinating disease utilizing myelin epitopes, such as myelin oligodendrocyte glycoprotein (MOG)35–55, induce a robust CD4 T cell response but mitigate the contribution of pathological B cells. This limits their efficacy for investigating how B cell depletion affects T cells. Furthermore, induction of experimental autoimmune encephalomyelitis with a single CD4 T cell epitope does not reflect the breadth of epitopes observed in the clinic. To better model the adaptive immune response, mice were immunized with the full-length MOG protein or the MOG1–125 extracellular domain (ECD) and compared with MOG35–55. Mature MOG-reactive B cells were generated only by full-length MOG or ECD. The CNS-localized T cell response induced by full-length MOG is characterized by a reduction in frequency and the percentage of low-affinity T cells with reactivity toward the core epitope of MOG35–55. B cell depletion with anti-CD20 before full-length MOG-induced, but not ECD-induced, demyelinating disease restored T cell reactivity toward the immunodominant epitope of MOG35–55, suggesting the B cell–mediated control of encephalitogenic epitopes. Ultimately, this study reveals that anti-CD20 treatment can influence T cell epitopes found in the CNS during demyelinating disease.
Inokulasi Aspergillus Niger, Trichoderma Viride, dan Saccharomyces Cerevisiae pada Manure Layer dalam Produksi Protein Sel Tunggal untuk Pakan Ternak
Authors: Ramaiyulis Ramaiyulis , Fajar Muhammad , Salvia Salvia 
Published: September 2024

Protein sel tunggal merupakan salah satu bahan sumber protein yang berasal dari mikroba dan dapat digunakan untuk menggantikan bahan pakan protein yang mahal. Penelitian ini bertujuan untuk mengetahui inokulasi Aspergillus niger, Trichoderma viride, dan Saccharomyces cerevisiae pada manure layer dalam produksi protein sel tunggal untuk pakan ternak. Metode penelitian ini menggunakan desain Rancangan Acak Lengkap (RAL) dengan 4 perlakuandan 4 ulangan. Perlakuan A (Trichoderma viride + Saccharomyces cerevisiae), B (Aspergillus niger + Saccharomyces cerevisiae), C ( Trichoderma viride + Aspergillus niger + Saccharomyces cerevisiae ), D (Aspergillus niger + Trichoderma viride + Saccharomyces cerevisiae). Parameter yang diamati dalam penelitian ini adalah kandungan bahan kering, kandungan protein kasar, dan produksi protein sel tunggal. Hasil penelitian ini menunjukkan persentase kandungan bahan kering berkisar 44,43% - 61,77%. Persentase kandungan protein kasar berkisar 17,33 – 21,68%. Produksi protein sel tunggal berkisar 754 (mg/ml) – 1.608 (mg/ml). Berdasarkan hasil penelitian disimpulkan inokulasi Aspergillus niger, Trichoderma viride, dan Saccharomyces cerevisiae pada manure layer berpengaruh nyata (P<0,05) terhadap kandungan bahan kering, kandungan protein kasar, dan produksi protein sel tunggal.
Efek Lama Fermentasi Air Nira dan Interval Hari Pemberian Sebagai Antibakteri, Kecernaan Protein Kasar dan Toksisitas terhadap Broiler
Authors: Mutiara Septin , Ramaiyulis Ramaiyulis , Salvia Salvia 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian fermentasi air nira terhadap kemampuan daya hambat bakteri Escherichia coli pada broiler. Penelitian ini menggunakan metode rancangan acak lengkap (RAL) pola faktorial yang terdiri dari 2 faktor. Faktor pertama adalah perlakuan lama fermentasi (4 perlakuan) dan faktor kedua adalah interval hari pemberian (3 perlakuan). Setiap perlakuan memiliki 3 ulangan, dimana setiap ulangan terdiri dari 5 ekor. Empat perlakuan faktor A tersebut adalah: A1 (fermentasi air nira selama 1 hari), A2 (fermentasi air nira selama 3 hari ), A3 (fermentasi air nira selama 5 hari )dan 3 perlakuan faktor B tersebut adalah: B0 (pemberian setiap hari), B1 (pemberian selang 2 hari), B2 (pemberian selang 3 hari). Parameter yang diukur adalah kemampuan daya hambat bakteri E-coli, dampak toksisitas dari pemberian fermentasi air nira terhadap broiler dan kecernaan protein kasar broiler. Hasil yang diperoleh dari penambahan fermentasi air nira dengan interval hari pemberian memiliki daya hambat sedang terhadap bakteri eschericia coli dan tidak memiliki dampak toksik terhadap broiler serta berpengaruh sangat nyata (P<0,01) terhadap kecernaan broiler.
Analisis Situational Awareness pada Petugas Lost and Found PT Kokapura Avia di Bandar Udara Internasional Yogyakarta (Study Literature)
Authors: Hardin Muhammad Andri , Widagdo Djoko 
Published: September 2024

Sebagai salah satu Bandara Internasional, petugas lost and found di Bandara Internasional Yogyakarta harus mampu untuk memberikan pelayanan dengan sebaik mungkin. Namun, kesulitan pada saat berkomunikasi dengan penumpang mancanegara menjadi suatu hambatan. Jumlah personel yang tidak memadai menyebabkan tingkat beban kerja yang lebih tinggi dan tuntutan situasional awareness yang lebih. Penelitian ini menggunakan jenis penelitian deskriptif kualitatif dengan metode studi literatur. Untuk dapat memperoleh jawaban dari penelitian maka peneliti membuat desain rancangan penelitian. Penelitian kualitatif merupakan penelitian yang digunakan untuk menyelidiki, menemukan, menggambarkan, dan menjelaskan kualitas dari pengaruh sosial. Hasil penelitian ini menunjukkan peningkatan situational awareness di unit Lost and Found Bandara Internasional Yogyakarta melalui penerapan teknologi (CCTV, AI, IoT), pelatihan rutin, dan strategi berbasis data memungkinkan penanganan bagasi yang hilang atau rusak lebih efisien. Koordinasi dengan tim terkait meningkatkan kinerja petugas, mempercepat pelacakan, dan meningkatkan kepuasan pelanggan.
Diables cupides ou soldats chrétiens ?
Authors: Alardin Gary 
Published: September 2024

Les guerres de Religion françaises sont marquées par l’emploi massif de troupes étrangères par tous les partis entre 1562 et 1598. Venus des États voisins du royaume, ceux qu’on appelle « mercenaires » marquent durablement les mémoires des guerres civiles. Ils demeurent le symbole de la cupidité et d’une violence indifférente à la fracture confessionnelle du royaume. Cette dernière ne serait alors pour eux qu’une formidable opportunité de faire du profit en allant vendre leurs services au plus offrant. Or, cette image sinistre est une construction partisane dont les origines remontent à l’époque même des conflits. Les polémistes du temps s’attachent à effacer toute forme de motivations confessionnelles ou de solidarité avec leurs coreligionnaires français, catholiques ou protestants. Ces auteurs façonnent une figure littéraire surtout utilisée pour attaquer leurs adversaires politiques. Ce portrait est plus tard réactivé par les nationalismes du XIX e siècle qui l’adaptent pour donner une profondeur historique à la xénophobie du temps. Dans cette veine, l’historiographie reste largement tributaire de cette vision qui ne résiste pas à une lecture croisée des sources françaises et étrangères. Une ouverture aux sources européennes suffit à fissurer ce portrait sans nuance et appelle à réexaminer le rapport entre l’intérêt financier et les convictions religieuses des mercenaires.
« Mauvais réflexe », de Zidane à Canguilhem
Authors: Andrieu Bernard , Félix François 
Published: September 2024

Le réflexe est un mouvement naturel et spontané qui semble dépourvu de teneur morale car il ne relèverait pas de la responsabilité du sujet. Il est ce qui échappe à la maitrise du corps et à la civilité des mœurs. Le mauvais réflexe se produit lorsque le corps réagit trop vite, emporté par la colère ou la situation dans un temps plus rapide que celui de la conscience réfléchie : le temps du corps vivant est en avance, par anticipation motrice, sur celui de la conscience du corps vécu. Relire avec les yeux de Georges Canguilhem le coup de tête de Zidane, mauvais réflexe face aux insultes de son adversaire en finale de la Coupe du monde de football de 2006, montrera de quelle façon la nervosité, de Descartes à l’électrophysiologie moderne, sert d’argument à une causalité neurophysiologique du mauvais réflexe.
Leibniz et la double liberté divine
Authors: Hayashi Takuya 
Published: September 2024

Le principe du meilleur n’ôte-t-il pas la réalité du choix divin de ce monde ? Comment est-il possible de préserver le libre arbitre de Dieu, si sa volonté est strictement déterminée par le jugement infaillible de sa sagesse ? La doctrine leibnizienne de la liberté divine n’a cessé d’être débattue. En revanche, l’historiographie a relativement négligé une option corollaire : pourquoi créer quelque chose plutôt que rien ? La distinction scolastique entre la liberté de spécification et la liberté d’exercice vaudrait-elle, d’une certaine manière, pour la pensée leibnizienne ? Le même type de nécessité s’applique-t-il à ces deux formes de liberté ? Cet article interroge la place de cette double liberté dans la pensée tardive de Leibniz autour de ses Essais de Théodicée, en prenant compte de sa doctrine de la Création et des attributs divins. Cette problématique est fondamentale, puisqu’elle interroge deux grandes questions associées au principe de raison et la limite de la raison humaine.
Co-evolution and Sustainable Procurement in Humanitarian Organizations: The Mediating effect of Self-organization
Authors: Aryatwijuka Dr Wilbroad , Arimpa Joan Shina , Mutebi Assoc Prof. Henry , Tukamuhabwa Assoc Prof. Benjamin , Muhwezi Prof. Moses 
Published: September 2024

Purpose: The study examined the role of self-organization in facilitating co-evolution and sustainable procurement in Humanitarian Organisations (HOs).
Materials and Methods: Using simple random sampling, data were collected from 79 Hos with respondents purposively selected following a quantitative cross-sectional design, which was analyzed through partial least structural equation modelling (PLS-SEM) using SmartPLS version 4.0.9.0.
Findings: Co-evolution and self-organization play a significant role in the attainment of sustainable procurement, and the relationship between co-evolution and sustainable Procurement is partially mediated by self-organization.
Implications: Co-evolutionary and self-organizing approach are introduced to allow humanitarian agencies procure sustainably during relief operations. HO procurement functions can interact with other partners in their procurement activities by continuously engaging each other and sharing resources.
By confirming mediation, the mediation role of self-organization in the relationship between co-evolution and sustainable procurement among HOs, the study provides critical insights in the evolving literature.
Implications to Theory, Practice and Policy: The study shows that co-evolution connects with self-organization and sustainable procurement. Furthermore, it explains how self-organization mediates the relationship between co-evolution and sustainable procurement.
The Hand Accumulation aNd Dexterity FUnctional Limits–Shriners (HANDFULS): A New Clinically Feasible Measure of Hand Volume and In-Hand Manipulation for Children
Authors: Parry Ingrid , Wilson Machelle , Starcevich Ana , Bettencourt Kory , Greenhalgh David , James Michelle 
Published: September 2024

Abstract
Importance: Having a problem-specific hand function test that can be administered easily with children is important for consistency in measuring and monitoring outcomes.
Objective: To introduce basic testing procedures for Hand Accumulation aNd Dexterity FUnctional Limits–Shriner (HANDFULS), a clinically feasible hand outcome measure for two common hand problems, in-hand manipulation and palmar workspace volume; examine its face validity and test–retest reliability; and provide reference values for children and adolescents with typically developed, noninjured hands as a foundation for further study.
Design: Prospective cohort study.
Setting: Pediatric hospital and surrounding community.
Participants: Children and adolescents, ages 2 to 20 yr, with typically developed, noninjured hands.
Intervention: A newly developed hand function test called HANDFULS.
Outcomes: HANDFULS measured palmar workspace volume, represented by the number of marbles children and adolescents could comfortably fit in their hand, and in-hand manipulation, represented by seconds per marble needed to collect the marbles in the hand.
Results: Results for the primary outcomes palmar workspace volume and the HANDFULS scores were reported by age group. For every year increase in age, HANDFULS score decreased by 0.02 s per marble (p &lt; .001). The test showed moderately high test–retest reliability (intraclass correlation coefficient = .84) and was typically administered in less than 5 min with supplies costing about $30.
Conclusions and Relevance: This study proposes a hand outcome measure that addresses a gap in the literature and clinical practice in the measurement of hand function.
Plain-Language Summary: The Hand Accumulation aNd Dexterity FUnctional Limits–Shriners (HANDFULS) offers a new, clinically feasible outcome tool for measuring in-hand manipulation (the number of seconds per marble a child or adolescent needs to collect marbles in one hand). HANDFULS simultaneously considers palmar workspace volume (the number of marbles a child or adolescent can comfortably fit in one hand) as a foundation for future testing with various patient populations to provide meaningful and relevant information about hand function.
USO DO LiDAR NA CARACTERIZAÇÃO DE ESTRATOS VEGETAIS EM FRAGMENTO DE MATA ATLÂNTICA: SUBSÍDIO À GESTÃO DE UNIDADE DE CONSERVAÇÃO
Authors: LEAL Thiago dos Santos , SILVA Dayane Andrade da , CAMPOS Maria Carolina Fernandes de , PIRES João Pedro Monção da Silva , ALMEIDA Ana Carolina Augusto de 
Published: September 2024

RESUMO - A necessidade de preservação e de recuperação de fragmentos de floresta ombrófila densa de Mata Atlântica em grandes centros urbanos, em especial das áreas protegidas, é de grande relevância pelos serviços ecossistêmicos ofertados. Neste contexto, o Parque Natural Municipal de Niterói (PARNIT), em especial o seu setor Montanha da Viração apresenta fragmentos florestais com grande biodiversidade, mas também áreas degradadas. Assim o objetivo deste trabalho é caracterizar a vegetação utilizando dados do LiDAR a partir do Modelo Digital de Altura da Vegetação (MDAV), aplicando os parâmetros altimétricos da Resolução CONAMA nº 006/1994 e da Lei Municipal n° 2602/2008, de forma a contribuir para uma melhor compreensão de suas ocorrências e potencial de restauração e, consequentemente, na melhor gestão da unidade de conservação. Os resultados mostraram uma predominância de indivíduos arbóreos, os quais ocupam 83,51% do setor estudado do PARNIT. Além disso, destaca-se a classe de tendência de floresta em estágio médio, representando 51,18% da vegetação encontrada neste setor da unidade de conservação. A partir do trabalho de campo para avaliação dos fragmentos com tendência de estágio sucessional avançado, foi observado em três áreas fragmentos de espécies exóticas e invasoras, demonstrando o potencial da ferramenta para a gestão ambiental.
Palavras-chave: LiDAR. PARNIT. Conservação. Sensoriamento Remoto.

ABSTRACT - The need to preserve and restore fragments of dense Atlantic rainforest in large urban centers, especially protected areas, is of great importance because of the ecosystem services they provide. In this context, the Niterói Municipal Natural Park (PARNIT), especially its Montanha da Viração sector, has forest fragments with great biodiversity, but also degraded areas. The work aims to characterize vegetation using LiDAR from the Digital Vegetation Height Model (MDAV), applying the altimetric parameters of CONAMA Resolution 006/1994 and Law 2602/2008 of the municipality, in order to contribute to a better understanding of its occurrences and restoration potential and, consequently, to better management of the conservation unit. The results showed a predominance of arboreal individuals, which occupy 83.51% of the studied sector of PARNIT. In addition, the medium-stage forest trend class stands out, representing 51.18% of the vegetation found in this sector of the conservation unit. Fieldwork to assess the fragments with an advanced successional stage trend revealed fragments of exotic and invasive species in three areas, demonstrating the tool's potential for environmental management.
Keywords: LiDAR. PARNIT. Conservation. Remote Sensing.
GEOCHEMISTRY AND MINERALOGY OF THE BANDED IRON FORMATION, WEST MOEDA SYNCLINE, QUADRILÁTERO FERRIFERO REGION
Authors: RONCATO Jorge , BARBOSA Letícia dos Santos , RIBEIRO Guilherme Henrique , MENDES Kaio Felipe , CARVALHO Marcos Vinicius Monteiro , PAULA Rodrigo Sérgio de , KNAUER Luiz Guilherme 
Published: September 2024

At the western flank of Moeda Syncline, a BIF-hosted with variable grades lithotypes: Hematite (>=64 wt.% Fe), Rich Itabirite (58 to 64 wt.% Fe), Intermediáte Itabirite (45 to 58 wt.% Fe), Poor Itabirite (20 to 45 wt.% Fe), Poor Limonitic Itabirite (20 to 45 wt.% Fe), Intermediate limonitic Itabirite (45 to 58 wt.% Fe) and Manganese-rich Itabirite (20 to 45 wt.% Fe). The metasedimentary sequence is stratigraphically correlatable with phyllites and quartzites of the Caraça Group at the base of the Minas Supergroup. The sedimentary/diagenetic bedding of the metamorphosed BIF (itabirites of the Cauê Formation) is generally transposed by a planar schistosity. The 76 drill holes carried out between 2005 and 2014, and nine additional samples taken from the deposit were classified into different facies of itabirite based on the degree of enrichment in iron, aluminum, and manganese in the chemical analyses, and the degree of compactness of the material, resulting in 11 different lithotypes (with their respective average iron values). Lithotypes with an Al2O3 content above 2% are called Limonitic, and those above 1% of Mn are Manganese. Both XRD and optical microscopy studies indicate a mineralogical composition of quartz, granular hematite, goethite, and a very fine-grained mixture of iron oxides and hydroxides (limonitic material). The diverse and extensive lithotypes pose considerable difficulties for exploration - as well as opportunities regarding different sample media and the formation of resources within them. The development of appropriate geochemical understanding is is exceedingly important for better exploratory planning. This data aims to provide a concise introduction to the ore geology of the part of Moeda Syncline iron ore deposit. The distribution, characteristics, and use of the principal sample media are described.
IDENTIFICAÇÃO E AVALIAÇÃO DO USO E OCUPAÇÃO DO SOLO DAS ÁREAS DE PRESERVAÇÃO PERMANENTE EM UMA SUB-BACIA HIDROGRÁFICA DO RIO DOCE
Authors: MENDES Larissa Gomes , CAMBRAIA NETO Arnaldo José , CUNHA Daniela Martins , PANQUESTOR Evandro Klen 
Published: September 2024

RESUMO - As Áreas de Preservação Permanente (APP), segundo a Lei Federal nº. 12.651/2012, são definidas como “áreas protegidas, cobertas ou não por vegetação nativa, com função ambiental de preservar os recursos hídricos, a paisagem, a estabilidade geológica e a biodiversidade, facilitar o fluxo gênico de fauna e flora, proteger o solo e assegurar o bem-estar das populações humanas”. Embora as APP sejam legalmente protegidas, a maioria acaba sendo afetada com as ações antrópicas. Devido à importância ambiental dessas áreas, tem se a necessidade de sua fiscalização e monitoramento, e para isso, os Sistemas de Informações Geográficas (SIG) surgem como uma grande ferramenta. Este estudo identificou e avaliou o uso e ocupação do solo das APP em uma sub-bacia hidrográfica do rio Doce. Estas representam, aproximadamente, 2,2 % da área total da sub-bacia e 42,83%, de seu total, se encontram preservadas. As condições do uso e ocupação do solo na área de estudo são uma representação do que se observa na bacia hidrográfica do rio Doce. Assim, a sua preservação e recuperação deve focar os esforços em suas sub-bacias, pois estas refletirão em toda bacia.
Palavras-chave: Código Florestal Brasileiro. Geoprocessamento. MapBiomas. Gestão Ambiental. Impactos Ambientais.

ABSTRACT - The Permanent Preservation Areas (APP), according to Federal Law no. 12,651/2012, are defined as “protected areas, covered or not by native vegetation, with the environmental function of preserving water resources, the landscape, geological stability and biodiversity, facilitating the gene flow of fauna and flora, protecting the soil and ensure the well-being of human populations”. Although APPs are legally protected, the majority end up being affected by human actions. Due to the environmental importance of these areas, there is a need for their inspection and monitoring, and for this, Geographic Information Systems (GIS) emerge as a great tool. This study identified and evaluated the use and occupation of APP land in a sub-watershed of the Doce River. These represent approximately 2.2% of the total area of the sub-watershed and 42.83% of the total are preserved. The conditions of land use and occupation in the study area are a representation of what is observed in the Doce river watershed. Therefore, its preservation and recovery must focus efforts on its sub-basins, as these will reflect on the entire watershed.
Keywords: Brazilian Forest Code. Geoprocessing. MapBiomas. Environmental Management. Environmental Impacts.
Developing the procedure of simulation of loading of the open-pit dump truck by means of cascading the external force factors
Authors: Dianov V. A. , Bokarev A. I. , Kartashov A. B. 
Published: September 2024

Introduction (problem statement and relevance). Ensuring the necessary strength, stiffness and durability of load-bearing structure components of open-pit dump trucks is an important engineering task in the absence of regulations and standards of loading simulation. Therefore, the focus area of developing and accumulating of the regulatory and methodical base for building an effective design process for chassis and load-bearing systems of open-pit dump trucks is highly relevant.The purpose of the study is to develop the procedure for simulation of open-pit dump truck loading by means of cascading the external force factors in order to determine the standardized sequence when forming a cascade of test loads acting on mechanical parts of the open-pit dump truck in the initial design stages.Methodology and research methods. According to the goals and objectives of the study, the following methods were assigned: the mathematical simulation method; statistical data processing methods; formalization and specification of calculated load cases based on vehicle theory formulas.Scientific novelty and results. The results are formed as a descriptive part of the main peculiarities of the open-pit dump truck loading simulation procedure as well as some intermediary approbation results proving the suitability, efficiency and reasonability of the procedure developed. The scientific novelty consists in application of the open-pit dump truck loading simulation method on the principle of “loading –unloading – statics” considering the simultaneous influence of inertia loads and loads in the tyre-to-road contact patch while maintaining the quasistable state of the dynamic model, which relatively reduces the simulation time by more than 20%.Practical significance. The procedure developed is recommended to be applied in the early design stages in order to simulate typical and non-typical open-pit dump truck operational conditions or modes so that to define the loads acting on the open-pit dump truck load-bearing system and chassis suspension guiding devices for further operational reliability calculations.