bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of exogenous leukemia inhibitory factor on reparative regeneration of the peripheral nerve in mice
Authors: Labunets I. , Demydchuk A. , Shamalo S. , Utko N. , Rodnichenko A. , Rymar S. , Chaikovsky Yu. , Butenko G. 
Published: December 2017

The role of trophic and growth factors in the regeneration of the damaged peripheral nerve is known. The leukemia inhibitory factor (LIF) exhibits properties not only of the polyfunctional cytokine, but also the neurotrophic factor. Regeneration of the peripheral nerve is impaired during oxidative stress in the area of injury.The purpose of the work was to investigate the effect of recombinant human LIF (rhLIF) on the efficacy of reparative regeneration of the sciatic nerve.Materials and methods. Adult male FVB/N mice were divided into the following groups: sham-operated; trauma (neurotomy) of the right sciatic nerve; nerve injury and subcutaneous injection of rhLIF at a dose of 1 μg per animal daily from the third day after the nerve injury. The study was conducted 4 weeks after the injury. At morphometry, the density of nerve fibers in distal nerve segments after impregnation with nitric oxide silver was evaluated. The motor function was evaluated in the “open field” test by the number of crossed squares, and in footprint test by the distance between the extreme toes of the right foot. In the area of muscle injury, the content of malondialdehyde, superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase was estimated.Results. The total number of nerve fibers in the distal segment of the nerve of mice with trauma and injection of rhLIF is greater (p < 0.05) than in mice with only nerve injury and does not differ from sham-operated animals. Horizontal motor activity in mice with nerve injury is lower (p <0.05) than in sham-operated and cytokine injected mice. The distance between the extreme toes of the sham-operated mice is greater (p < 0.05) than in mice with nerve injury, as well as injuries and injections of rhLIF, but after the injection of cytokine, the rates are higher (p < 0.05) than in the group of mice without it. After the injury, the content of malondialdehyde and catalase activity increases in muscle tissue, while the activity of glutathione reductase decreases (p < 0.05). Under the influence of rhLIF, the parameters change to the values of sham-operated mice, and, in addition, the activity of the glutathione peroxidase is significantly increased.Conclusions. Injection of rhLIF to mice with a sciatic nerve injury promotes a more complete restoration of the structural organization of the damaged nerve and improves the motor function of the injured limb. At the same time, the balance between the factors of oxidative stress and antioxidant system is improved in the muscle tissue in the area of the nerve injury.
DESCRIPTION OF DENTAL CARIES AND EFFECTS OF FOODS ON TOOTH DESTRUCTION IN SKULLS OF PAWON MAN
Authors: Ahmad Amalina , Aripin Dudi , Yondri Lutfi 
Published: December 2017

The skeleton of Pawon Man’s that lived in Mesolitic era aged 5,660±170 BP - 9,500± 200 BP (Before Present) years before Christ (BC) has been used for forensic odontology research. However, there has not been any research on dental caries of Pawon Man. The aim of this research was to describe the dental caries in skulls of Pawon Man. The type of the research was descriptive by using purposive sampling. The samples were from four Pawon Man skulls and their teeth. The research was conducted by using clinical examination. All aspects were recorded, collected and presented in tabular form. The result shows that 12.5% of the samples from 32 teeth of skulls of Pawon Man I, III, IV and V had experienced dental caries. Clinical examination shows presence of dental caries in samples of Pawon Man III of permanent mandibular third molar tooth of region 4(48) in lingual area and buccal lesion of lower left third molar (38). In Pawon IV, lingual lesion of lower left permanent second molar (37) and in lower left permanent third molar (38). All lesions are only in enamel which is code 1 according to ICDAS code. In conclusion, the dental caries in skulls of Pawon Man was low due to their low sugar diets from fruits and sugar-rich plants (fructose sugars). Consumption of hard foods and evidence of presence of animal teeth and mollusks had contributed to the higher percentage of dental attrition compared to dental caries. Keywords: dental caries, clinical, pawon man
La tierra y el hombre en la Tierra de Campos vallisoletana a mediados del siglo XVIII
Authors: Cubero Garrote José , Hernández García Ricardo 
Published: December 2017

A pesar de la importancia que a lo largo de la historia ha tenido la comarca de la Tierra de Campos, los estudios centrados en este ámbito para el siglo XVIII son muy escasos. Por ello en este trabajo, y gracias a las Respuestas Generales del Catastro de Ensenada, se ha analizado cuál era la situación del poblamiento y de la población de la comarca, así como la situación de su principal actividad económica, la agricultura. El trabajo se ha centrado en la comarca de la Tierra de Campos en la actual provincia de Valladolid, territorio que engloba a 82 localidades. Gracias al análisis conjunto de las 40 preguntas del Interrogatorio del Catastro para todos estos pueblos se ha conseguido determinar aquellos componentes que eran comunes a la comarca y que en buena medida la moldeaban en este periodo, así por ejemplo, el tipo y volumen de poblamiento, las medidas de tierra, la distribución de cultivos o la productividad de la tierra. Gracias a todo ello, se ha podido caracterizar de una manera mucho más homogénea a la comarca de lo que se había hecho hasta ahora.
Magnetic resonance imaging measurements of organs within the coelomic cavity of red-eared sliders (Trachemys scripta elegans), yellow-bellied sliders (Trachemys scripta scripta), Coastal plain cooters (Pseudemys concinna floridana), and hieroglyphic river cooters (Pseudemys concinna hieroglyphica)
Authors: Mathes Karina A. , Schnack Marcus , Rohn Karl , Fehr Michael 
Published: November 2017

Abstract
OBJECTIVE To determine anatomic reference points for 4 turtle species and to evaluate data on relative anatomic dimensions, signal intensities (SIs), and position of selected organs within the coelomic cavity by use of MRI.
ANIMALS 3 turtle cadavers (1 red-eared slider [Trachemys scripta elegans], 1 yellow-bellied slider [Trachemys scripta scripta], and 1 Coastal plain cooter [Pseudemys concinna floridana]) and 63 live adult turtles (30 red-eared sliders, 20 yellow-bellied sliders, 5 Coastal plain cooters, and 8 hieroglyphic river cooters [Pseudemys concinna hieroglyphica]).
PROCEDURES MRI and necropsy were performed on the 3 turtle cadavers. Physical examination, hematologic evaluation, and whole-body radiography were performed on the 63 live turtles. Turtles were sedated, and MRI in transverse, sagittal, and dorsal planes was used to measure organ dimensions, position within the coelomic cavity, and SIs. Body positioning after sedation was standardized with the head, neck, limbs, and tail positioned in maximum extension.
RESULTS Measurements of the heart, liver, gallbladder, and kidneys in sagittal, transverse, and dorsal planes; relative position of those organs within the coelom; and SIs of the kidneys and liver were obtained with MRI and provided anatomic data for these 4 turtle species.
CONCLUSIONS AND CLINICAL RELEVANCE MRI was a valuable tool for determining the position, dimensions, and SIs of selected organs. Measurement of organs in freshwater chelonians was achievable with MRI. Further studies are needed to establish reference values for anatomic structures in turtles. Results reported here may serve as guidelines and aid in clinical interpretation of MRI images for these 4 species.
Investigation of the Effect of Grain Size, Flow Rate and Diffuser Design on the CAWST Biosand Filter Performance
Authors: Chan Colleen C.V. , Neufeld Kyle , Cusworth Darien , Gavrilovic Stevan , Ngai Tommy 
Published: December 2017

The effects of grain size, hydraulic loading rate, batch residence time and diffuser design on the performance of the CAWST version 10 biosand filter was investigated. Two types of sand gradations were prepared – fine sand (ES = 0.20, UC = 2.3) and a coarse sand (ES = 0.25, UC = 2.9). The fine sand and coarse grains resulted in initial hydraulic loading rates of 0.3 m3/m2 min and 0.75 m3/m2 min, respectively. Flow restrictions were installed on 2 coarse grain filters such that their initial hydraulic loading rates were 0.3 m3/m2 min. For the range of grain size and flow rates investigated in this paper, coarse grain size leads to lower bacterial removal efficiencies compared to the fine grain size. The addition of flow restrictions on filters with coarse grain size did not result in improvement in bacterial removal efficiencies. Two different diffuser designs were also investigated (hole size of 1/8 inch or 3.2 mm and 0.5 inch or 12.7 mm spacing, hole size of 3/16 inch or 9.5 mm and 0.5 inch or 12.7 mm spacing). These filters were compared to the standard design of CAWST version 10 filter, i.e. control filter, which has a hole size of 1/8 inch (3.2 mm) and 1 inch (25.4 mm) spacing. Diffuser design was found to have an effect on the bacterial removal efficiency. The two diffuser investigated (smaller hole size, tighter spacing) resulted in lower bacterial removal efficiencies, compared to the CAWST specified diffuser design. Batch residence time was found to have a significant effect on bacterial removal. The deficiencies caused by diffuser design, coarse grain size were compensated by a higher batch residence time.
Applying Evaluative Thinking to a Community-Engaged Safe Drinking Water Project in Peri-Urban Guatemala
Authors: Tendick-Matesanz Felipe , Ahonen Emily Q. , Zellner Moira L. , Lacey Steven E. 
Published: December 2017

A large number of safe drinking water programs fail to create long-lasting solutions because safe drinking water problems are complex and necessitate multiple kinds of expertise at several levels of influence over often long periods of time to succeed. Such work is especially challenging in a service-learning context. Process-oriented ways of working such as evaluative thinking and community engagement may be useful ways to frame iterative phases of work on drinking water projects. Here we describe our use of both in an interdisciplinary university student project to develop and implement collaborative plans for a safe drinking water intervention in peri-urban Guatemala, complications related to its implementation, and measures and sources of data for evaluating health, energy, and cost outcomes over time. We also assess our successes and failures to date. Though full implementation of the intervention has not been achieved and work is ongoing, we provide this report as an outline which other groups pursuing public health engineering projects may find useful.
Evaluation of the artherogenic potential of homocysteine and its cytotoxic effect on HUVECs
Authors: AGGOUN ChÃ©rifa , ELOUAR Ibtissem , LAMDA Souad , NAIMI Dalila 
Published: December 2017

Background: In recent decades, several studies have shown that hyperhomocysteinemia is an independent risk factor for atherosclerosis. The objective of this work is, first, to assess the atherogenic potential of homocysteine in rats and and appraise its effect on endothelial cells: the main components of the blood vessel.
Methods: In the in vivo study, hyperhomocysteinemia is induced in rats by a diet supplemented with L-methionine (1 g/kg/day). After 21 days of treatment, a blood sample is performed for biochemical study (total cholesterol, triglycerides, HDL, LDL cholesterol, ALT, AST, CRP, and total protein) and a removal of organs (aorta, liver, and heart) for the assay MDA and histological study. For the in vitro study, HUVECs were cultured for 24 h then exposed to various concentrations of homocysteine (2 mM, 4 mM, 8 mM). After 24 hours, we confirm the cellular phenotype and its number.
Results: The angiotoxic dose of methionine induces a significant increase for all biochemical parameters (except HDL-C, which is diminished). In addition, an alteration of the histological structure of the aorta (appearance of foam cells) of the liver (steatosis) and of the heart. The in vitro study revealed a senescent phenotype of HUVECs and an inhibition of cell proliferation.
Conclusion: Our results suggest that homocysteine is involved in the genesis of atherosclerosis by affecting directly the endothelial cells.
Toxicological risks of water and human health, contribution to the biological treatments in the dam of Ain Zada
Authors: Gourari Bariza , Anteur Djamel 
Published: December 2017

Background: Freshwater fish play a role in detoxification of certain germs and pathogens of bacteria. Variation of the content of pathogenic bacteria are, mainly, total coliform, fecal coliform, and fecal streptococci in the study sites of the sampling period. The objective of this study is inventoried purifying species of dam of Ain Zada.
Methods: The isolation of fecal coliform (CF) and total coliform (CT) was conducted by incorporation in agar of the five shot test (0,4 mL; 1 mL et 3 x 2 mL). The culture medium is the selective agar Mac Conkey (HIMEDIA, M083) coliforms. The enumeration of the colonies is done after 24 of incubation at 37Â°C for total coliforms and 44Â°C for fecal coliforms. The isolation of fecal streptococci (SF) is made by the same method but on the culture medium incubated at 37Â°C for 48 hours. Counting of colonies is done on mailboxes where 100 to 300 colonies are developed. The average of colonies counted is then determined. The boxes do not contain at least 100 colonies, all of the colonies on all boxes are counted, taking into account the total volume inoculated in water. In the second part, there is an inventory of purifying fish at the Ain Zada dam level.
Results: The result indicate that all the fish that play a role in the treatment of dam of Ain Zada (Bordj Bou Arreridj) who use these germs and bacteria as a food source. We registered the presence of a single family, with five (05) genera divided into seven (07) species, including the majority of alien species are Cyprinid fish: Sander lucioperca L., Ctenopharyngodon idella, Clarias gariepinus, Cyprinus carpio, Hypophthalmichthys molitrix and Hypophtalmichthys nobilis.
Conclusion: The Bousselam and Ouricia valleys feature heavily poor microbiological quality; exploitation of these waters could constitute a health hazard on dam Ain Zada. According to this study, the fish play a role of biological control.
Prospective observational study in early breast cancer at University Hospital of Tlemcen
Authors: Lahfa- Merad I , Aris H , Chaibdraa Tani S , Hammou-Tani N , Saidi S , Ghomari S 
Published: December 2017

Background: Breast cancer is the first cancer in women in Algeria. It affects a significant proportion of young women. Stage at diagnosis is made with a positive, massive, and often lymph node involvement. The objective of this study is to determine the clinicopathological and histological features of patients treated for invasive breast carcinoma.
Methods: This is an observational prospective study from January 2006 to December 2011 done at the medical oncology department at the University Hospital Center of Tlemcen: 103 patients with early breast cancer were included.
Results: Extreme age is between 29 and 70 years; 50% of patients are under 47 years. The average age at diagnosis of 46.45 Â± 0.90 years; 54% are stage T2; 17% are stage T3 and 4% stage T4; stage III is the most frequent with 50.4%. Half of patients have four to nine nodes with relatively wide tumor size, and only one patient was stage I; 10% had more than 10 positive nodes. The infiltrating ductal carcinoma is the most common histological types (83.5%), followed by atypical carcinoma (5.82%). Note the predominance of grade II of Scarf Bloom and Richardson (58.25%), followed by grade III (36.89%) and grade I (1.91%). Over 50% of patients had a tumor size of 35.41 Â± 1.82 mm. Hormone receptors were positive in 65% of patients (ER + PR +) and negative in 35%. HER2 status was determined in 82 patients, 12% expressed a positive score, and 67% of were negative. The luminal profile is the most common in our study population with 57.3%, followed by triple negative tumors or basal-like with 26.8%. Conservative surgical treatment was realized in 2.9% and an astectomy in most patients at 97%. Radiotherapy was performed in 83.5% of patients, and 65% of patients received hormone therapy according to hormone positivity.
Conclusion: The clinical and histological profiles of the patients in our study population are different from Western populations by the average age of diagnosis of 46 years, 10 years higher for Western women, and the stage is more advanced for our population. The majority are at stage III, while Western women are diagnosed at stage I or II through screening. Given the Algerian profile, women should be offered screening at aged 40 years for earlier diagnosis and improved survival rate.
HEALTH INFORMATION SEARCH ENGINE THE NEW TOOLS OF HEALTH LITERACY
Authors: Ebnehoseini Zahra 
Published: December 2017

Introduction:
Access to Health Information is very essential for promoting health literacy, self-care, shared decision making, medication adherence. The Internet is one of the main resources of health information. Many studies showed the main gateway for seeking health information was search engines. But finding qualified health information is a challenge. Therefore, this study aimed to introduce top health Searches engines and review their features.
Methods:
According to the literature review, 10 health Searches engines were selected. Common features of each search engine, such as the ability to create profiles, the type of health information provided, target users, health information sources contained in the search engine, and the unique feature and other features, were reviewed and the comparison table was provided. A common search scenario was also tested on all search engines and the result of the data retrieval was reported by the search engine.
Results:
health Searches engine like that PubMed، Med scape، McGraw-Hill Medical، iMediSearch، medicin.net, Hardin.Md، Health line ، EMedicine، Merck and Ovid were chosen and reported.
Conclusion:
The results of this study can help users such as patient to choose a valid health searches engine and also help them to find health searches engine appropriate for their health problem and know what features in health website is important.
Improvement of patient safety through implementation of electronic medical records
Authors: Gozali Elahe , Ghazisaiedi Marjan , Sadeghi Malihe , Safdari Reza 
Published: December 2017

Introduction: Today, with the complexity of the process of conducting activities, the increase in diversity and the number of hospital services, and the increase in the expectations of clients - consistent with the fast technological advances - most of the hospitals in Iran have turned to mechanized systems to organize their daily activities and to register the patients' information and the care provided. One of these technologies is electronic medical records, which is known as a valuable system to evaluate patients' information in hospitals. The purpose of this paper was to examine the advantages of running electronic medical records in patient safety.
Methods: This study is a review paper based on a structured review of papers published in the Google Scholar, SID, Magiran, Pubmed, and Science Direct databases (from 2007 to 2015) and the books on the benefits of implementing electronic medical records in patient safety and the related keywords.
Results: Clinical information systems can have a significant effect on the quality of the outputs and patient safety. Various studies have indicated that the physicians with access to clinical guidelines and features such as computer reminders, doctors who did not have these features, presented more appropriate preventive care. Studies show that electronic medical records play a crucial role in improving the quality of patient health and safety services. Moreover, electronic medical record system is usually in connection with other technological tools: electronic drug management records,
electronic record of time and date of drug management are usually associated with bar code technology. Among the benefits of this system is the possibility to record clinical care by the treatment team, which would be especially beneficial for patient's bedside record. If the treatment personnel forgets to ask the patient a particular question, system reminds him/her. Furthermore, electronic medical record is able to remind the nurses of the patient's allergic reactions and medical history without the need for the patient to remind, which improves patient safety.
Conclusion: Implementation of electronic medical records boosts up the quality of health services, patient safety, people's access to health care services, and the speed of patients treatment, leading to lower healthcare costs. Thus, considering the benefits mentioned and some other benefits of this kind, one can use this technology in clinical care provided to patients to come up with a safe and effective clinical care.