bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lean body mass as an independent determinant of dose‐limiting toxicity and neuropathy in patients with colon cancer treated with FOLFOX regimens
Authors: Ali Raafi , Baracos Vickie E. , Sawyer Michael B. , Bianchi Laurent , Roberts Sarah , Assenat Eric , Mollevi Caroline , Senesse Pierre 
Published: January 2016

AbstractEvidence suggests that lean body mass (LBM) may be useful to normalize chemotherapy doses. Data from one prospective and one retrospective study were used to determine if the highest doses of oxaliplatin/kg LBM within FOLFOX regimens would be associated with dose‐limiting toxicity (DLT) in colon cancer patients. Toxicity over four cycles was graded according to NCI Common Toxicity Criteria V2 or V3 (Common Terminology Criteria for Adverse Events, National Cancer Institute, Bethesda, MD). Muscle tissue was measured by computerized tomography (CT) and used to evaluate the LBM compartment of the whole body. In prospective randomized clinical trials conducted in France (n = 58), for patients given FOLFOX‐based regimens according to body surface area, values of oxaliplatin/kg LBM were highly variable, ranging from 2.55 to 6.6 mg/kg LBM. A cut point of 3.09 mg oxaliplatin/kg LBM for developing toxicity was determined by Receiver Operating Characteristic (ROC) analysis, below this value 0/17 (0.0%) of patients experienced DLT; in contrast above this value 18/41 (44.0%) of patients were dose reduced or had treatment terminated owing to toxicity (≥Grade 3 or neuropathy ≥Grade 2); for 9/41 the DLT was sensory neuropathy. These findings were validated in an independent cohort of colon cancer patients (n = 80) receiving FOLFOX regimens as part of standard care, in Canada. Low LBM is a significant predictor of toxicity and neuropathy in patients administered FOLFOX‐based regimens using conventional body surface area (BSA) dosing.
Boron Arylations of Subporphyrins with Aryl Zinc Reagents
Authors: Kotani Ryota , Yoshida Kota , Tsurumaki Eiji , Osuka Atsuhiro 
Published: January 2016

AbstractBoron arylations of B‐(methoxo)triphenylsubporphyrin have been developed with a combined use of ArZnI⋅LiCl and trimethylsilyl chloride. Aryl zinc reagents bearing bromo, cyano, amide, and ester groups can be employed for the B‐arylation reaction to provide the corresponding B‐arylated subporphyrins in moderate yields. Postmodifications of B‐arylated subporphyrins have been demonstrated without loss of the B−C bond. These modifications include conversion of the cyano group into a benzoyl group with PhMgBr, hydrolysis of the ester group to give B‐(4‐carboxyphenyl)subporphyrin, and Pd‐catalyzed Suzuki–Miyaura coupling of the 4‐bromophenyl group to give a 1,4‐phenylene‐bridged subporphyrin–ZnII porphyrin hybrid that displays intramolecular excitation energy transfer from the subporphyrin to the porphyrin. The newly synthesized B‐arylated subporphyrins have been fully characterized by NMR, UV/Vis absorption and fluorescence spectroscopies, mass spectrometry, electrochemical measurements, and X‐ray diffraction analysis.
Über die besonderen Herausforderungen einer Promotion am Fachgebiet Verfahrenstechnik der Technischen Universität Berlin
Authors: Rosenberger Sandra , Drews Anja 
Published: January 2016

AbstractEine Promotion ist mental herausfordernd, aber am Fachgebiet Verfahrenstechnik der TU Berlin ist sie es überdies auch physisch. Der Doktorvater besitzt nicht nur eine hohe Körperlänge, sondern neigt auch zu außerordentlich schnellem Gehen. Auf Basis theoretischer Überlegungen zur Pendelbewegung und experimenteller Befunde aus der Literatur diskutiert diese Arbeit, ob und wie seine DoktorandInnen mit ihm Schritt halten können.
Risk factors for depression and fatigue among survivors of hematopoietic cell transplantation
Authors: Jim Heather S.L. , Sutton Steven K. , Jacobsen Paul B. , Martin Paul J. , Flowers Mary E. , Lee Stephanie J. 
Published: January 2016

BACKGROUNDPatients treated with hematopoietic cell transplantation (HCT) often experience depression and fatigue but analyses to determine risk factors have typically lacked statistical power. The current study examined sociodemographic and clinical risk factors for depression and fatigue in a large cohort of survivors of HCT.METHODSMeasures of depression and fatigue were included in an annual survey of HCT recipients that also included self‐reported sociodemographic and health information. Patient clinical characteristics were obtained from the clinical database.RESULTSThe sample consisted of 1869 recipients (with a mean age of 56 years; 53% male) who were a mean of 13 years (allogeneic recipients) and 6 years (autologous recipients) from HCT. Moderate to severe depression was reported by 13% of participants; moderate to severe fatigue was reported by 42%. Among allogeneic recipients, female sex, younger age, current presence of chronic pain, and current patient‐reported severity of chronic graft‐versus‐host disease were found to be independently associated with greater depression whereas female sex, current presence of chronic pain, and current severity of chronic graft‐versus‐host disease were independently associated with greater fatigue (P values <.01). Among autologous recipients, younger age and current presence of chronic pain were found to be independently associated with both greater depression and greater fatigue (P values <.01).CONCLUSIONSRates of depression and fatigue in this group of survivors suggest a high symptom burden. Better screening, referral, and interventions are needed. Cancer 2016;122:1290–7. © 2016 American Cancer Society.
Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of ASP2408, a Potent Selective T‐Cell Costimulation Modulator After Single and Multiple Ascending Doses in Healthy Volunteers and RA Patients
Authors: Zhu Tong , Keirns James , Howieson Corrie , Kaibara Atsunori , Goldwater Ronald , Kivitz Alan J. , Chindalore Vishala , Cohen Stanley , Santos Vicki , Akinlade Bolanle , Kernstock Robert , Delgado‐Herrera Leticia , Blahunka Paul C , Karrer Erik E. , Garg Jay P. , Samberg Nancy , Zeiher Bernhardt G. 
Published: January 2016

AbstractASP2408 is a next‐generation anti–cytotoxic T lymphocyte antigen‐4 fusion protein engineered for improved CD86 binding affinity as a treatment for rheumatoid arthritis (RA). In 72 healthy subjects (n = 6/treatment), ASP2408 was administered as single ascending doses intravenously at 0.003 to 10.0 mg/kg or subcutaneously at 0.3 to 3.0 mg/kg. It showed decreased clearance and prolonged half‐life with increasing doses, consistent with target‐mediated disposition. The apparent bioavailability was 36.3%–56.7% across single subcutaneous doses. Sixteen RA patients (n = 8/treatment) on stable methotrexate received 3 × 3.0 mg/kg subcutaneously every 4 weeks or every 2 weeks. Similar to single‐dose treatment, ASP2408 concentrations peaked 2 to 3 days postdose, with a median t1/2 of approximately 8 days. Using CD86 receptor occupancy (RO) as a mechanistic biomarker, ASP2408 demonstrated dose‐dependent binding to its target. ASP2408 3.0 mg/kg subcutaneously every 4 weeks and every 2 weeks led to a mean %CD86 RO ≥ 74.7% and ≥ 81.5%, respectively, within each dosing interval. ASP2408 was well tolerated across studies with no evidence of dose‐limiting toxicity or clinically significant changes in clinical laboratory test results, vital signs, or 12‐lead electrocardiograms. ASP2408 elicited antidrug antibodies in the majority of patients, but with no clinical sequelae.
Nonequilibrium Green Functions Approach to Strongly Correlated Fermions in Lattice Systems
Authors: Schlünzen N. , Bonitz M. 
Published: January 2016

AbstractQuantum dynamics in strongly correlated systems are of high current interest in many fields including dense plasmas, nuclear matter and condensed matter and ultracold atoms. An important model case are fermions in lattice systems that is well suited to analyze, in detail, a variety of electronic and magnetic properties of strongly correlated solids. Such systems have recently been reproduced with fermionic atoms in optical lattices which allow for a very accurate experimental analysis of the dynamics and of transport processes such as diffusion. The theoretical analysis of such systems far from equilibrium is very challenging since quantum and spin effects as well as correlations have to be treated non‐perturbatively. The only accurate method that has been successful so far are density matrix renormalization group (DMRG) simulations. However, these simulations are presently limited to one‐dimensional (1D) systems and short times. Extension of quantum dynamics simulations to two and three dimensions is commonly viewed as one of the major challenges in this field. Recently we have reported a breakthrough in this area [N. Schlünzen et al., Phys. Rev. B (2016)] where we were able to simulate the expansion dynamics of strongly correlated fermions in a Hubbard lattice following a quench of the confinement potential in 1D, 2D and 3D. The results not only exhibited excellent agreement with the experimental data but, in addition, revealed new features of the short‐time dynamics where correlations and entanglement are being build up. The method used in this work are nonequilibrium Green functions (NEGF) which are found to be very powerful in the treatment of fermionic lattice systems filling the gap presently left open by DMRG in 2D and 3D.In this paper we present a detailed introduction in the NEGF approach and its application to inhomogeneous Hubbard clusters. In detail we discuss the proper strong coupling approximation which is given by T ‐matrix selfenergies that sum up two‐particle scattering processes to infinite order. The efficient numerical implemen‐tation of the method is discussed in detail as it has allowed us to achieve dramatic performance gains. This has been the basis for the treatment of more than 100 particles over large time intervals. The numerical results presented in this paper concentrate on the diffusion in 1D to 3D lattices. We find that the expansion dynamics consist of three different phases that are linked with the build‐up of correlations. In the long time limit, a universal scaling with the particle number is revealed. By extrapolating the expansion velocities to the macroscopic limit, the obtained results show excellent agreement with recent experiments on ultracold fermions in optical lattices. Moreover we present results for the site‐resolved behavior of correlations and entanglement that can be directly compared with experiments using the recently developed atomic microscope technique. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Atypical early histories predict lower extraversion in captive chimpanzees
Authors: Freeman Hani D. , Weiss Alexander , Ross Stephen R. 
Published: January 2016

ABSTRACTAlthough much research has been conducted to understand personality development in humans, there remain substantial gaps in our understanding of these processes, particularly in relation to social influences. As such, investigations into personality development in our closest living relative, the chimpanzee, may provide useful insight. We evaluated the impact of early social exposure (to both humans and conspecifics) on personality development by studying 88 chimpanzees, including former pets and entertainers, living in accredited zoos and sanctuaries. During infancy, subjects varied in the amount of time spent with conspecifics compared with humans. Caregivers familiar with the chimpanzees rated them using a modified version of the Hominoid Personality Questionnaire (HPQ) and the ratings were found to have strong inter‐rater reliability. We used the published structure of the HPQ to evaluate our results in relation to differences in early life experience. Chimpanzees who as infants spent less time with conspecifics were rated as lower in Extraversion later in life in comparison with chimpanzees who as infants spent more time with conspecifics. These results suggest that a broad range of social influences should be considered when evaluating the impact of early social environment on later personality expression. © 2016 Wiley Periodicals, Inc. Dev Psychobiol 58: 519–527, 2016.
Surgical treatment of the Charcot foot
Authors: Pinzur Michael S. 
Published: January 2016

AbstractWith the increased number of diabetics worldwide and the increased incidence of morbid obesity in more prosperous cultures, there has become an increased awareness of Charcot arthropathy of the foot and ankle. Outcome studies would suggest that patients with deformity associated with Charcot Foot arthropathy have impaired health related quality of life. This awareness has led reconstructive‐minded foot and ankle surgeons to develop surgical strategies to treat these acquired deformities. This article outlines the current clinical approach to this disabling medical condition. Copyright © 2016 John Wiley & Sons, Ltd.
Innovations in diabetic foot reconstruction using supermicrosurgery
Authors: Suh Hyun Suk , Oh Tae Suk , Hong Joon Pio 
Published: January 2016

AbstractThe treatment of diabetic foot ulceration is complex with multiple factors involved, and it may often lead to limb amputation. Hence, a multidisciplinary approach is warranted to cover the spectrum of treatment for diabetic foot, but in complex wounds, surgical treatment is inevitable. Surgery may involve the decision to preserve the limb by reconstruction or to amputate it. Reconstruction involves preserving the limb with secure coverage. Local flaps usually are able to provide sufficient coverage for small or moderate sized wound, but for larger wounds, soft tissue coverage involves flaps that are distantly located from the wound. Reconstruction of distant flap usually involves microsurgery, and now, further innovative methods such as supermicrosurgery have further given complex wounds a better chance to be reconstructed and limbs salvaged. This article reviews the microsurgery involved in reconstruction and introduces the new method of supermicrosurgery. Copyright © 2016 John Wiley & Sons, Ltd.
Integrating palliative care with usual care of diabetic foot wounds
Authors: Dunning Trisha 
Published: January 2016

AbstractPalliative care is a philosophy and a system for deciding care and can be used alone or integrated with usual chronic disease care. Palliative care encompasses end‐of‐life care. Palliative care aims to enhance quality of life, optimize function and manage symptoms including early in the course of chronic diseases. The purposes of this article are to outline palliative care and discuss how it can be integrated with usual care of diabetic foot wounds. Many people with diabetes who have foot wounds also have other comorbidities and diabetes complications such as cardiovascular and renal disease and depression, which affect medicine and other treatment choices, functional status, surgical risk and quality of life. Two broad of diabetic foot disease exist: those likely to heal but who could still benefit from integrated palliative care such as managing pain and those where healing is unlikely where palliation can be the primary focus. People with diabetes can die suddenly, although the life course is usually long with periods of stable and unstable disease. Many health professionals are reluctant to discuss palliative care or suggest people to document their end‐of‐life care preferences. If such preferences are not documented, the person might not achieve their desired death or place of death and health professionals and families can be confronted with difficult decisions. Palliative care can be integrated with usual foot care and is associated with improved function, better quality of life and greater patient and family satisfaction. Copyright © 2016 John Wiley & Sons, Ltd.
The effects of proliferation and DNA damage on hematopoietic stem cell function determine aging
Authors: Khurana Satish 
Published: January 2016

AbstractIn most of the mammalian tissues, homeostasis as well as injury repair depend upon a small number of resident adult stem cells. The decline in tissue/organ function in aged organisms has been directly linked with poorly functioning stem cells. Altered function of hematopoietic stem cells (HSCs) is at the center of an aging hematopoietic system, a tissue with high cellular turnover. Poorly engrafting, myeloid‐biased HSCs with higher levels of DNA damage accumulation are the hallmark features of an aged hematopoietic system. These cells show a higher proliferation rate than their younger counterparts. It was proposed that quiescence of these cells over long period of time leads to accumulation of DNA damage, eventually resulting in poor function/pathological conditions in hematopoietic system. However, various mouse models with premature aging phenotype also show highly proliferative HSCs. This review examines the evidence that links proliferation of HSCs with aging, which leads to functional changes in the hematopoietic system. Developmental Dynamics 245:739–750, 2016. © 2016 Wiley Periodicals, Inc.
Old males reduce melanin‐pigmented traits and increase reproductive outcome under worse environmental conditions in common kestrels
Authors: Lopez‐Idiaquez David , Vergara Pablo , Fargallo Juan Antonio , Martinez‐Padilla Jesús 
Published: January 2016

AbstractSecondary sexual traits displayed by males and females may have evolved as a signal of individual quality. However, both individual quality and investment on producing or maintaining enhanced sexual traits change as individuals age. At the same time, the costs associated to produce sexual traits might be attenuated or increased if environmental conditions are benign or worse respectively. Accordingly, environmental conditions are expected to shape the association between the expression of sexual traits and their reproductive outcome as individuals age. Nonetheless, little is known about the environmental influence on the co‐variation between sexual traits and reproductive outcome throughout the life of individuals. We studied the age‐dependency of the number and size of back spots, a melanin‐based and sexual trait in adults of common kestrels (Falco tinnunculus). We analysed the age‐dependence of reproductive traits and the environmental influence, defined as vole abundance, using a 10‐year individual‐based dataset. We broke down age‐related changes of reproductive traits into within‐ and between‐individual variation to assess their contribution to population‐level patterns. Our results showed a within‐individual decrease in the number, but not the size, of back spots in males. The size of back spots was positively correlated with food availability in males. Reproductive performance of males increased as they aged, in agreement with the life‐history theory but depending of vole abundance. Remarkably, we found that having fewer back spots was positively associated with clutch size only for old individuals under low‐food conditions. We suggest that environmental variation may shape the association between the expression of a sexual signal and reproductive outcome. We speculate that the reliability of sexual traits is higher when environmental conditions are poor only for old individuals. Within an evolutionary context, we suggest that the expression of sexual traits might be constrained by environmental conditions at later stages of life.
Ferrocenyl Dithiocarbamate Based d10 Transition‐Metal Complexes as Potential Co‐Sensitizers in Dye‐Sensitized Solar Cells
Authors: Yadav Reena , Trivedi Manoj , Kociok‐Köhn Gabriele , Chauhan Ratna , Kumar Abhinav , Gosavi Suresh W. 
Published: January 2016

AbstractThree new d10 transition‐metal dithiocarbamates containing ferrocene, namely [M(FcCH2EtOHdtc)2] (M = Zn, Cd and Hg; dtc = dithiocarbamate) have been synthesized and characterized by elemental analyses, IR, 1H, and 13C NMR spectroscopy, and X‐ray crystallography. The coordination geometries around the zinc and mercury ions in the complexes are distorted tetrahedral and distorted linear, respectively. The distorted linear geometry around the mercury complex can be attributed to the presence of the bulky methylferrocenyl groups. These complexes have been used in dye‐sensitized solar cells (DSSCs) as co‐sensitizers and co‐adsorbents. The assembly fabricated by using the zinc complex and N719 (Zn/N719) showed the best performance with an overall photon‐to‐current conversion efficiency (PCE) of 7.10 ± 0.02 %, which is an improvement of 23 % in the cell performance compared with the DSSC fabricated by using N719 (PCE 5.76 ± 0.04 %) alone under identical conditions.
A Ruthenium Complex/Carbon Nanotube Based Electrode as the First Electrochemical Sensor for Simultaneous Sensing of D‐Penicillamine, 6‐Thioguanine and Catecholamines
Authors: Mazloum‐Ardakani Mohammad , Sheikh‐Mohseni Mohammad Ali , Salavati‐Niasari Masoud 
Published: January 2016

AbstractThe electrochemical behavior of a synthesized Ru complex (RuL) was investigated at multiwalled carbon nanotubes modified carbon paste electrode. Some special properties of the electrochemical response of this modified electrode are suitable charge transfer rate, repeatability and independance of the pH of the solution. The modified electrode can catalyze the electrochemical oxidation of penicillamine (PA) by a heterogeneous chemical reaction between PA and RuL through catalytic EC’ mechanism. The rate constant of this catalytic reaction was obtained as 1.4×106 M−1 s−1 by chronoamperometry. Because of increasing the anodic current and decreasing the oxidation potential of PA at the prepared modified electrode, this electrode was used as an electrochemical sensor for determination of PA. This sensor can determine the concentration of PA in the wide concentration range of 0.20–750.0 µM with the low detection limit of 80 nM. Simultaneous determination of PA and 6‐thioguanine in the presence of catecholamines is the other important advantage of this sensor.
The Effect of Different Carbon Materials on Manganese Oxide‐Based Lithium–Air Batteries in Ambient Environment
Authors: Zhu Yongming , Shi Haihao , Hu Huili 
Published: January 2016

AbstractRodlike manganese oxide (α‐MnO2) was prepared through a homogeneous hydrothermal reaction. Air electrodes, made with a mixture of graphite/acetylene black (G/AB) with and without the as‐made α‐MnO2, were prepared for lithium–air cells. Linear sweep voltammetry (LSV) results show that the as‐made α‐MnO2 can greatly increase the rate of the oxygen reduction reaction (ORR), and that the graphite has a very low catalytic activity towards ORR, while acetylene black has a better catalytic activity towards ORR. The batteries were tested in ambient atmosphere. The results show that graphite can improve the charge and discharge performance, and acetylene black can improve the specific capacity. When using 28 % α‐MnO2+56 % graphite as catalyst, the initial discharge capacity was 200 mAh g−1, and the number of cycles reached up to 5. When using 28 % α‐MnO2+56 % acetylene black as catalyst, the initial discharge capacity was 1150 mAh g−1, but did not realize the charge and discharge cycles.