bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Color of Zirconia in Different Substrates of Osseointegrated Implants, Thickness of Materials and Types of Resin Cements
Authors: Seyidaliyeva Aida , Zenthöfer Andreas , Rues Stefan 
Published: September 2024

Objectives: To evaluate the impact of surface conditioning of titanium, zirconia thickness, and cement type on the final color of zirconia luted to the titanium.Methods: A total of 192 grade 5 titanium specimens with the final dimensions 10 mm × 10 mm × 2 mm were fabricated and subjected to four different surface conditioning including, that is, sandblasting, etching, and anodization. In addition, 192 zirconia specimens with the same dimensions as the titanium specimens but altered thicknesses of 0.7 (n = 96) and 1.0 (n = 96) mm were fabricated using 5Y‐TZP zirconia. Color as expressed by L∗ (lightness), a∗ (red–green axis), and b∗ (blue–yellow axis) of titanium and zirconia specimens as well as the joined titanium–zirconia complex, total assembly (Panavia V5 clear, PC; opaque, PO, each n = 96) were determined under standardized conditions using a spectroradiometer (SpectraScan P‐650). Color differences were calculated using the ΔE00 formula. ANOVA supplemented with post hoc Tukey test for group comparisons was compiled to estimate possible effects of titanium conditioning, zirconia thickness, and type of cement used on the final zirconia color (SPSS Ver. 28; α = 0.05).Results: All investigated factors affected the zirconia color of the total assembly (p  < 0.001). Using PO mean values of all groups were still close to baseline colors (ΔE00 between 5.5 and 6.2). When using PC, the final color was significantly altered, irrespective of the other parameters. Specimens luted with PO appeared lighter, less reddish (a∗ was affected predominately by sample thickness), and more bluish, while luting with PC resulted in reduced lightness combined with large shifts along the red and yellow axes.Significance: Color changes of zirconia luted to titanium are primarily affected by the color of the substrate if a translucent cement was used. Vice versa, the application of an opaque cement effectively masked the dark substrate color. Substrate color and choice of cement have to be taken into consideration when performing shade selection.
Reduced Platelet Activation in Triple-Negative Essential Thrombocythemia Compared with JAK2V617F-Mutated Essential Thrombocythemia
Authors: Dong Huan , Chen Jia , Zhang Jing , Xue Feng , Li Huiyuan , Zhang Donglei , Zhou Hu , Zhang Xian , Huang Yueting , Liu Xiaofan , Chen Yunfei , Liu Wei , Chi Ying , Wang Wentian , Sun Ting , Ju Mankai , Dai Xinyue , Gu Wenjing , Yang Renchi , Fu Rongfeng , Zhang Lei 
Published: September 2024

Abstract

Purpose:
Triple-negative (TN) essential thrombocytopenia (ET) is characterized by the absence of driver mutations while retaining histologic and phenotypic characteristics sufficient for an ET diagnosis. Our understanding of TN-ET and its platelet activation remains incomplete. We carried out a large-scale multicenter clinical analysis to analyze the clinical and molecular characteristics and thrombotic complications of TN-ET. We also related the above characteristics to platelet activation to further explore the thrombosis mechanism of TN-ET.

Experimental Design:
A retrospective multicenter study was conducted on 138 patients with TN-ET and 759 patients with ET with driver mutations from March 1, 2012 to December 1, 2021. The clinical and molecular characteristics of the patients with TN-ET were summarized. Additionally, platelet activation, apoptosis, and reactive oxygen species (ROS) levels were analyzed in 73 patients with TN-ET from this cohort and compared with 41 age- and sex-matched healthy donors.

Results:
Compared with patients with the JAK2V617F mutation, those with TN mutation were younger (P &lt; 0.001) and exhibited fewer thrombotic events before diagnosis (P &lt; 0.001) and during follow-up (P = 0.039). Patients with TN mutation also presented with significantly reduced CD62P expression in platelets (P = 0.031), slightly reduced calcium concentration in platelets (P = 0.063), increased mitochondrial membrane potential (P = 0.011), reduced phosphatidylserine exposure (P = 0.015), reduced levels of ROS (P = 0.043) and MitoSOX in platelets (P = 0.047).

Conclusions:
In comparison with JAK2V617F-mutated ET, TN-ET is associated with lower platelet ROS levels, which leads to reduced platelet activation and consequently a lower risk of thrombosis.
Cb-WoFS: Migrating the Warn-on-Forecast System to the Cloud
Authors: Martin Joshua J. , Clark Adam J. , Yussouf Nusrat , Wicker Louis , Heinselman Pamela , Knopfmeier Kent , Matilla Brian C. , Burke Patrick C. , Adili Salar 
Published: September 2024

Abstract
This article provides a brief, technical narrative of the WoFS journey to a cloud-based high-performance computing (HPC) system, including some of the technological challenges encountered and solutions found. Also, discussed are a few new components that are in development for cloud-based Warn-on-Forecast System (cb-WoFS), such as the cloud infrastructure project for managing resources, as well as a new web application that manages cb-WoFS runs. An important initial step in our cloud journey is containerizing all of the compiled applications, such as WRF, GSI, and EnKF and their dependencies like netCDF and MPI. With these applications compiled within an Apptainer container, WoFS can run on any local or cloud-based HPC cluster that supports MPI. Furthermore, an additional software layer was developed that creates and manages cloud vendor resources. This layer, which is referred to as the WoFS framework, contains the workflow required to run cb-WoFS, as well as management for other aspects of cb-WoFS (including but not limited to creation of HPC pools in the end-to-end workflow, runtime notifications, and database management). This additional layer was developed to separate the WoFS business logic from vendor-specific API calls. The WoFS framework exposes features through its service library, which is then referenced by the newly developed cb-WoFS web application and other cloud applications. This makes WoFS a complete end-to-end cloud-based application, where an administrator can launch a model run, manage resources, and view output all within a single web app.
Impacts of the Madden–Julian Oscillation on the Flash Drought Occurrence over the Lancang–Mekong River Basin
Authors: Chen Guiwan , Ling Jian , Lin Zhaohui , Xiao Ziniu , Li Chongyin 
Published: September 2024

Abstract
This study explores the potential impacts of the Madden–Julian oscillation (MJO) on flash drought occurrence over the Lancang–Mekong River basin (LMRB). The flash drought events are identified across individual grid cells from gridded datasets, based on the rapid decline rate in soil moisture and dry persistency of flash droughts. The onset of flash drought is typically accompanied by precipitation deficit and abnormal increase in surface air temperature (SAT). Both the onset and persistency risks of flash drought vary significantly depending on the MJO phase. Generally, the onset and persistency risks of flash droughts over the LMRB increase when the MJO convection is active over the Indian Ocean (phases 2–3), while decrease when the MJO is active over the Pacific Ocean (phases 6–7). The MJO primarily influences flash droughts over the lower reaches of the LMRB by modulating SAT and precipitation. During MJO phases 2–3, there exists significant increased SAT and preceding precipitation deficit over the lower reaches, leading to decline in soil moisture. During MJO phases 6–7, there are decreased SAT and preceding increased precipitation. Diagnosis results revealed that the impact of the MJO on SAT over the lower reaches is dominated by large-scale temperature advection associated with the MJO-induced vertical and meridional circulation anomalies, while its impact on precipitation is mainly modulated by the MJO-induced zonal wind gradients. This study emphasizes the importance of considering the effects of the MJO on precipitation and SAT for predicting flash droughts over the LMRB.
Establishing Benchmarks for Airway Replacement: Long-Term Outcomes of Tracheal Autografts in a Large Animal Model
Authors: Liu Lumei , Sher Ada C. , Arsuaga-Zorrilla Carmen , Shamim Humra , Nyirjesy Sarah , Shontz Kimberly M. , Hussein Zakarie , Sussman Sarah , Manning Amy , Chiang Tendy 
Published: September 2024

Objective: Airway replacement is a challenging surgical intervention and remains an unmet clinical need. Due to the risk of airway stenosis, anastomotic separation, poor vascularization, and necrosis, it is necessary to establish the gold-standard outcomes of tracheal replacement. In this study, we use a large animal autograft model to assess long-term outcomes following tracheal replacement. Methods: Four New Zealand White rabbits underwent tracheal autograft surgery and were observed for 6 months. Clinical and radiographic surveillance were recorded, and grafts were analyzed histologically and radiographically at endpoint. Results: All animals survived to the endpoint with minimal respiratory symptoms and normal growth rates. No complications were observed. Computed tomography scans of the post-surgical airway demonstrated graft patency at all time points. Histological sections showed no sign of stenosis or necrosis with preservation of the native structure of the trachea. Conclusion: We established benchmarks for airway replacement. Our findings suggest that a rabbit model of tracheal autograft with direct reimplantation is feasible and does not result in graft stenosis or airway collapse.
The association between neighborhood socioeconomic deprivation and mental health in low- and middle-income countries: A scoping review
Authors: Sharifi Vandad , Amini Homayoun , Radman Narges , Noorbakhsh Hoora , McClurg Caitlin , Patten Scott B 
Published: September 2024

Background: Environmental research on mental health primarily originates from high-income countries, while information about the rest of the world remains limited. Aims: This study examined: (1) the available published research evidence regarding the association between neighborhood-level deprivation and indicators of mental health and illness in low- and middle-income countries (LMICs), and (2) the gaps in the relevant research in LMIC settings that should be addressed in future studies. Method: First, we systematically searched for relevant primary studies in electronic databases (Ovid Medline, Scopus, Socindex, and PsycINFO) and citations in the reference lists. Then, a two-stage screening procedure was employed to select the relevant studies by screening the titles and abstracts and reviewing the selected full texts by independent researchers. After charting the data from the selected study reports, we collated, summarized, and discussed the results. Results: We retrieved 51 studies across 19 LMICs, with only one study originating from a low-income country. Most studies focused on adult mental health topics and few explored children’s mental health. Notably, a significant majority of these studies ( N = 37) reported a positive association between neighborhood deprivation and mental health/disorder. However, the research methods used varied significantly, and there were several methodological limitations. Conclusions: This review highlights the need for more original studies in LMICs on the association between neighborhood deprivation and mental health, employing stronger methodologies.
New Breakthroughs in Hindered Amine Light Stabilizer Performance
Authors: Vulic I. , Eng J.M. , Samules S.-B. , Wagner A.H. 
Published: September 2024

The role of hindered amine light stabilizers (HALS) in the protection of polyolefins continues to expand. HALS are essential components in formulations developed for outdoor use and have been proven to be effective thermo-oxidative stabilizers. The physicochemical properties of hindered amines have a profound effect on the hindered amine’s performance as a stabilizer, and will also influence the reactivity of the HALS with other formulation components, environmental agents, etc. Some of these interactions can have a deleterious effect on end product aesthetics and service life. Studies on the relationship between HALS structure and performance have led to the development of new products which provide optimal light stabilizing efficiency while minimizing the tendency to undergo undesirable side reactions with system components or external agents. These new products and their application in PP fibre, PE film, and other applications will be described.
Impact of a Structured Roadmap, Individual Accountability and Support, and Outcome Measurement on the Culture of Scholarship in a Residency Program
Authors: Waheed Abdul , Azhar Erum , Aziz Faisal , Nasir Munima , Chaudhary Muhammad Ali , Wang Li 
Published: September 2024

BACKGROUND Despite scholarly activity being an accreditation requirement for residency programs by the Accreditation Council for Graduate Medical Education (ACGME) since 2006, many family medicine programs have struggled to meet this requirement. A myriad of approaches and curricula have been proposed to enhance the scholarly output of residency programs. OBJECTIVES To determine the impact of a multimodal curricular intervention consisting of clear expectations, structured roadmap, availability of resources, and standardized accountability on the scholarly activity of residents. METHODS This is a quasi-experimental study with a retrospective data collection. The scholarly activities of residents completing training in the pre-intervention (2009-2012) and post-intervention period (2013-2017) were compared. Chi-square, Fisher's exact, Mann Whitney U, and Kruskal Wallis H tests were utilized to detect differences between the pre- and post-intervention groups. Multivariable Poisson regression models were used to detect independent predictors of per-resident scholarly activity. The institutional review board determined that the study was exempt from full review. RESULTS A total of 67 residents, 20 (30%) pre-intervention and 47 (70%) post-intervention, were included in the analysis. The number of total scholarly activities per resident increased significantly in the post-intervention period after adjusting for confounding factors (1.9 vs 6.4). The number of scholarly activities per resident also showed an increasing trend over time ( P = .04). Moreover, traditional scholarship, including published manuscripts (0.35 vs 2.43) and national-level presentations (0.35 vs 1.27) also increased in the post-intervention period. CONCLUSION Implementing this comprehensive curriculum increased the scholarly output of residents and helped enrich the scholarship culture in the residency program.
Association of busulfan exposure and outcomes after HCT for patients with an inborn error of immunity
Authors: Bognàr Tim , Garcia-Rosa Moises , Lalmohamed Arief , Güngör Tayfun , Hauri-Hohl Mathias , Prockop Susan , Oram Layne , Pai Sung-Yun , Brooks Jordan , Savic Rada M. , Dvorak Christopher C. , Long-Boyle Janel R. , Krajinovic Maja , Bittencourt Henrique , Teyssier Anne-Charlotte , Théorêt Yves , Martinez Cary , Egberts Toine C. G. , Morales Erin , Slatter Mary , Cuvelier Geoffrey D. E. , Chiesa Robert , Wynn Robert F. , Coussons Mary , Cicalese Maria P. , Ansari Marc , Long Susan E. , Ebens Christen L. , Lust Hannah , Chaudhury Sonali , Nath Christa E. , Shaw Peter J. , Keogh Steven J. , van der Stoep M. Y. Eileen C. , Bredius Robbert , Lindemans Caroline A. , Boelens Jaap-Jan , Bartelink Imke H. 
Published: September 2024

Abstract
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative treatment strategy for patients with inborn errors of immunities (IEIs). The objective of this study was to assess the optimal busulfan exposure before allogeneic HCT for patients with an IEI who received an IV busulfan–based conditioning regimen. Patients from 17 international centers were included. The main outcome of interest was event-free survival (EFS). Patients were categorized into 4 IEI subgroups: combined immunodeficiency (CID), severe combined immunodeficiency (SCID), neutrophil disorders, and hemophagocytic lymphohistiocytosis (HLH)–related disorders. Busulfan exposure was calculated by individual centers (area under the curve [AUC]CENTER) and re-estimated using a nonlinear mixed–effects model (NONMEM; exposure defined as AUCNONMEM). Overall, 562 patients were included: 173 (30.8%) with CID, 154 (27.4%) with SCID, 101 (18.0%) with HLH-related disorders, and 134 (23.8%) with neutrophil disorders. The median busulfan AUCNONMEM was 69.0 mg × h/L and correlated poorly with the AUCCENTER (r2 = 0.54). In patients with SCID, HLH-related, and neutrophil disorders with a busulfan AUCNONMEM of 70 to 90 mg × h/L, 2-year EFS was superior to &lt;70 mg × h/L, and &gt;90 mg ×h/L. Full donor chimerism increased with higher busulfan AUCNONMEM, plateauing at 90 mg × h/L. For patients with CID, the optimal AUCNONMEM for donor chimerism was found to be &gt;70 mg × h/L. Improved EFS and higher donor chimerism may be achieved by targeting a cumulative busulfan AUCNONMEM of 80 mg × h/L (range, 70-90). Our study stresses the importance of uniformly using a validated population pharmacokinetic model to estimate AUCNONMEM.
Association of PH-Targeted Therapy and Survival in Precapillary PH with mPAP between 21 and 24 mmHg
Authors: Yogeswaran Athiththan , Fünderich Meike , Olschewski Horst , Kovacs Gabor , Kiely David G , Lawrie Allan , Hassoun Paul M. , Balasubramanian Aparna , Konswa Ziad , Pepke-Zaba Joanna , Cannon John , Wilkins Martin R. , Howard Luke , Ghofrani Hossein Ardeschir , Grimminger Friedrich , Seeger Werner , Tello Khodr 
Published: September 2024

Introduction. Pulmonary hypertension (PH) definition was recently changed and led to a new subset of PH patients with mildly impaired pulmonary hemodynamics, characterized by a mean pulmonary artery pressure of 21–24 mmHg and with a pulmonary vascular resistance >2Wood Units. We evaluated the association of PH-targeted therapy and outcome in mild precapillary PH using the PVRI GoDeep meta-registry.Methods. All patients with mild precapillary PH (mPAP 21–24 mmHg, PAWP ≤15 mmHg, PVR >2WU) diagnosed with PAH and CTEPH were enrolled. Patients were considered treated if PH-targeted therapy was initiated within 6 months of diagnostic right heart catheterization. Various statistical models, including in-depth sensitivity analyses, were used to examine the association between PH-targeted therapy and transplant-free survival.Results. 132 patients with group 1 or group 4 mild PH were identified, of whom 34 patients received PH-targeted therapy. There were no differences in baseline hemodynamics between untreated and treated groups, while treated patients suffered more frequently from renal comorbidities and required long-term oxygen treatment more often. Most prescribed were phosphodiesterase-5-inhibitors. PH-targeted therapy was associated with significantly higher survival rates, compared to those without treatment. Cox-regression analysis revealed significantly reduced hazard ratios among treated patients in Cox-regression analyses adjusted for various confounders. Subgroup analyses in PAH (n=78) similarly indicated higher survival rates and reduced hazard ratios in treated patients.Conclusion. PH-targeted therapy may be associated with improved survival in PAH and CTEPH patients with mild PH. To mitigate potential bias of the results due to the retrospective study design, randomized controlled trials are warranted.
Optimal spirometry thresholds for the prediction of chronic airflow obstruction: a multinational longitudinal study
Authors: Lam Abby H.S. , Alhajri Sheikhah A. , Potts James , Harrabi Imed , Anand Mahesh Padukudru , Janson Christer , Nielsen Rune , Agarwal Dhiraj , Malinovschi Andrei , Juvekar Sanjay , Denguezli Meriam , Gislason Thorarinn , Jõgi Rain , Garcia-Larsen Vanessa , Ahmed Rana , Nafees Asaad Ahmed , Koul Parvaiz A. , Aquat-Stewart Althea , Burney Peter , Knox-Brown Ben , Amaral Andre F.S. 
Published: September 2024

IntroductionChronic airflow obstruction is key for COPD diagnosis but strategies for its early detection are limited. We aimed to define the optimal z-score thresholds for spirometry parameters to discriminate chronic airflow obstruction incidence.MethodsThe Burden of Obstructive Lung Disease study is a multinational cohort study. Information on respiratory symptoms was collected and pre- and post-bronchodilator spirometry was performed at baseline. Eighteen study sites were followed up with repeat measurements after a median of 8.4 years. We converted lung function measurements into z-scores using the Third National Health and Nutrition Survey reference equations. We used the Youden index to calculate the optimal z-score thresholds for discriminating chronic airflow obstruction incidence. We further examined differences by smoking status.ResultsWe analysed data from 3057 adults (57% females, mean age: 51 years at baseline). Spirometry parameters were good at discriminating chronic airflow obstruction incidence (AUC 0.80–0.84), while respiratory symptoms performed poorly. The optimal z-score threshold was identified for pre-bronchodilator FEV1/FVC <-1.336, equivalent to the 9th percentile (sensitivity: 78%, specificity: 72%). All z-score thresholds associated with a lower post-bronchodilator FEV1/FVC and greater odds of chronic airflow obstruction at follow-up. The risk of chronic airflow obstruction was slightly greater for current smokers and, to some extent, never smokers with a pre-bronchodilator FEV1/FVC less than the 9th/10th percentiles at baseline, particularly among males.ConclusionsSpirometry is better than respiratory symptoms at predicting chronic airflow obstruction incidence. A pre-bronchodilator FEV1/FVC <9th/10th percentiles, particularly among current smokers, could suggest early airflow obstruction or pre-COPD.
Targeting PYK2, entrectinib allays anterior subcapsular cataracts in mice by regulating TGFβ2 signaling pathway
Authors: Ding Xuefei , Li Xiaohe , Fang Rui , Yue Peilin , Jia Yuxuan , Li Enjie , Hu Yayue , Zhou Honggang , Song Xudong 
Published: September 2024

Abstract
Background
Fibrosis cataract occurs in patients receiving cataract extraction. Still, no medication that can cure the disease exists in clinical. This study aims to investigate the effects and mechanisms of Entrectinib on fibrotic cataract in vitro and in vivo.

Methods
The human lens cells line SRA 01/04 and C57BL/6J mice were applied in the study. Entrectinib was used in animals and cells. Cataract severity was assessed by slit lamp and Hematoxylin and Eosin staining. Expression of alpha-smooth muscle actin, fibronectin, and collagen I were examined by real-time quantitative PCR, western blotting, and immunofluorescence. Cell proliferation was evaluated by Cell Counting Kit-8. Cell migration was measured by wound healing and transwell assays. Molecular docking, Drug Affinity Responsive Target Stability, and Cellular Thermal Shift Assay were applied to seek and certify the target of Entrectinib treating fibrosis cataract.

Results
Entrectinib can ameliorate fibrotic cataract in vitro and in vivo. At the RNA and the protein levels, the expression of alpha-smooth muscle actin, collagen I, and fibronectin can be downgraded by Entrectinib, while E-cadherin can be upregulated. The migration and proliferation of cells were inhibited by Entrectinib. Mechanistically, Entrectinib obstructs TGFβ2/Smad and TGFβ2/non-Smad signaling pathways to hinder the fibrosis cataract by targeting PYK2 protein.

Conclusions
Targeting with PYK2, Entrectinib can block TGF-β2/Smad and TGF-β2/non-Smad signaling pathways, lessen the activation of EMT, and alleviate fibrosis cataract. Entrectinib may be a potential treatment for fibrosis cataract in clinic.