bluuebunny/crossref_metadata_2025_split huggingface dataset:
Freshwater Turtles in an Arid Land: Population Ecology, Habitat and Ecological Niche Modelling of Pelomedusa subrufa olivacea in the Sahel
Authors: Lankoande Ardjima , Konate Sidiki Roland , Sirima Djidama , Dayama Wendata Francis , Hema Emmanuel M. 
Published: September 2024

ABSTRACTTurtle ecology and conservation have been poorly explored in the West African Sahel regions, and this scarce information has produced a suboptimal management of their populations in the wild. In order to enhance the knowledge on the Sahelian turtle ecology, a field study was carried out in Burkina Faso on the ecology of Pelomedusa subrufa olivacea, a freshwater species inhabiting a wide range of waterbodies throughout West Africa. Reasoned sampling was carried out, resulting in the collection of a total of 196 individuals of Pelomedusa subrufa olivacea. This species shows a relatively balanced distribution of age and sex classes of individuals surveyed in the different study areas. The majority of individuals were observed in specific habitats, confirmed by an aggregative distribution. The potential habitats identified by the MaxEnt model highlight key areas for the conservation of this species in Burkina Faso. Conservation efforts should focus on protecting and restoring temporary and permanent aquatic habitats, and managing human activities to minimize the impact on turtle populations in the West African Sahel.
Ileocolic resection with temporary ileostomy for Crohn's disease: does it affect long‐term disease recurrence compared with primary anastomosis?
Authors: Goldenshluger Michael , Segev Lior 
Published: September 2024

AbstractBackgroundWe aimed to assess whether the risk of disease recurrence in Crohn's disease (CD) patients that undergone ileocolic resection (ICR) with temporary ileostomy and a later stoma reversal is different compared to patients that underwent a one‐stage operation.MethodsA single‐center retrospective review of all patients that underwent elective primary ICR for CD between 2010 and 2022 divided into: 2S‐ICR group‐patients who underwent two‐stage ICR. 1S‐ICR group‐patients who underwent one‐stage ICR.ResultsThe cohort included 191 patients (mean age 33.4, range 15–70), with 40 and 151 patients in the 2S‐ICR and 1S‐ICR groups, respectively. The 2S‐ICR were more comorbid, with a lower mean BMI (18 vs. 21.3, P < 0.001), higher median ASA score (3 vs. 2, P = 0.036), higher percentage on pre‐operative total parenteral nutrition (TPN) (62.5% vs. 24.5%, P < 0.001), and lower levels of pre‐operative albumin (3.3 g/dL vs. 3.8 g/dL, P < 0.001). There were no significant differences in the overall postoperative complication rate (47.5% vs. 47.7% respectively, P = 1), nor in the rate of severe complications (17.5% vs. 13.2%, P = 0.6), but, the 2S‐ICR had a longer post‐operative length‐of‐stay (14 vs. 6 days, P < 0.001) and higher rates of 30‐day readmission (30% vs. 13.2%, P = 0.017). After an overall median follow‐up of 63 months, the groups showed similar rates of endoscopic, clinical, and surgical recurrence.ConclusionsTwo‐stage ICR with a temporary ileostomy does not change long‐term CD recurrence rates compared with one‐stage ICR.
One‐third of children had clinical signs of developmental coordination disorder 6 months after their international adoption
Authors: Heikkilä Anna‐Riitta , Elovainio Marko , Raaska Hanna , Lapinleimu Helena 
Published: September 2024

AbstractAimOur aim was to fill a gap in the research about the prevalence of developmental coordination disorder (DCD) among internationally adopted children. We explored the prevalence of signs of DCD and the associations between those and behavioural problems six and 18 months after adoption.MethodsThe data came from the ongoing Finnish Adoption Study 2 and this research focused on the international adoptions of children under 7 years of age between 2012 and 2016. Their motor development was tested with the Movement Assessment Battery for Children, Second Edition to identify DCD symptoms. Behavioural symptoms were measured using the Child Behavior Checklist (CBCL). Only children aged 3 years plus were tested.ResultsThe 95 children (70% boys) arrived in Finland at a mean age of 3.3 years. Six months later, 35% of the 49 children who were tested had clinical DCD symptoms and this has fallen to 13% of 67 at 18 months. Symptoms at 6 months were associated with higher internalising CBCL scores at 18 months.ConclusionDCD symptoms in internationally adopted children were double the rate in the general child population 18 months after adoption. Early motor problems 6 months after adoption were associated with later behavioural symptoms.
ERK1/2 pro‐survival signalling is suppressed by pirtobrutinib in ibrutinib‐resistant MYD88‐mutated lymphoma cells
Authors: Munshi M. , Liu X. , Kofides A. , Tsakmaklis N. , Hunter Z. R. , Guerrera M. L. , Canning A. , Gustine J. N. , Liu S. , Hatcher J. M. , Chen J. , Meid K. , Sarosiek S. , Flynn C. A. , Branagan A. R. , von Keudell G. , Palomba L. M. , Castillo J. J. , Yang G. , Treon S. P. 
Published: September 2024

SummaryCovalent Bruton's tyrosine kinase‐inhibitors (cBTK‐i) are highly active in MYD88‐mutated (MYD88Mut) Waldenstrom's macroglobulinaemia and suppress nuclear factor kappa‐light‐chain‐enhancer of activated B cells and extracellular signal‐regulated kinases‐1/2 (ERK1/2)‐related signalling. BTKCys481 mutations are associated with cBTK‐i acquired resistance and are accompanied by reactivation of ERK1/2 that promotes inflammatory cytokine secretion and paracrine‐mediated resistance of BTK wild‐type (BTKWT) tumour cells. Pirtobrutinib is a non‐covalent BTK‐inhibitor that binds at non‐BTKCys481 sites. We show that pirtobrutinib blocked p‐ERK1/2, ERK1/2‐driven inflammatory cytokines, and overcame paracrine‐mediated resistance in MYD88Mut lymphoma cells expressing mutated BTKCys481. Our results provide important mechanistic insights for the activity of pirtobrutinib in MYD88Mut lymphomas carrying BTKCys481 mutations.
Cytogenetic abnormality in non‐systemic light chain amyloidosis monoclonal gammopathy of renal significance: A field needs to be explored
Authors: Huang Xianghua 
Published: September 2024

The role of cytogenetic abnormalities in non‐systemic light chain amyloidosis monoclonal gammopathy of renal significance diseases still needs to be clarified. Bhutani et al. present the results of a study investigating the underlying plasma cell cytogenetic abnormalities in monoclonal immunoglobulin deposition disease (MIDD). The results show that translocation (11;14) is a common abnormality in MIDD and affects the presentation and outcomes.Commentary on: Bhutani et al. Translocation (11;14) is a common cytogenetic abnormality in clonal plasma cells in monoclonal immunoglobulin deposition disease. Br J Haematol 2024; 205:1860‐1865.
Philadelphia‐like B‐cell acute lymphoblastic leukaemia: Disease features and outcomes in the era of immunotherapy
Authors: Ashouri Karam , Hom Brian , Ginosyan Anush A. , Rahimi Yekta , Resnick Karen , Nittur Vinay , Hwang Jennifer , Ireland Robert , Ann Brandon , Adnani Blake , Bragasin Eljie Isaak , Chaudhary Preet , Ali Amir , Woan Karrune , Tam Eric Leon , Siddiqi Imran , Ladha Abdullah , Yaghmour George 
Published: September 2024

SummaryPhiladelphia chromosome (Ph)‐like acute lymphoblastic leukaemia (ALL) is a high‐risk subtype with a gene expression profile similar to Ph‐positive ALL, due to activation of tyrosine kinase signalling. To understand the clinical implications of Ph‐like ALL, this single‐centre retrospective study evaluates outcomes in 268 adults, largely Hispanic ALL patients treated between 2013 and 2024, with a subgroup analysis of 139 haematopoietic stem cell transplantation (HSCT) patients. ALL subtypes included 68 (25.4%) Ph‐like, 89 (33.2%) Ph‐positive, and 111 (41.4%) Ph‐negative. Ph‐like patients were the youngest age at diagnosis (p = 0.007), most likely to have refractory disease (p < 0.001), and least likely to achieve minimal residual disease (MRD) negativity after induction (p = 0.031). Relative to Ph‐negative ALL, Ph‐like achieved worse event‐free survival (EFS) (HR = 1.66; 95% CI 1.12–2.46; p = 0.012), whereas Ph‐positive had improved EFS (HR = 0.60; 95% CI 0.38–0.93; p = 0.024) and cumulative incidence of relapse (CIR) (HR = 0.59; 95% CI 0.35–0.99; p = 0.046). Within the transplant subgroup, Ph status did not impact disease‐free survival (DFS), CIR, or overall survival (OS). However, patients who received blinatumomab within 1‐year pre‐HSCT had improved DFS (HR = 0.43; 95% CI 0.20–0.94; p = 0.034) and CIR (HR = 0.26; 95% CI 0.09–0.75; p = 0.13). In conclusion, our data suggest that Ph‐like is less likely to respond to standard induction therapy and HSCT may result in similar survival outcomes to Ph‐negative ALL.
Communication Partners' Perceptions of Their Roles and Responsibilities in the Design, Planning and Use of Augmentative and Alternative Communication With Individuals With Severe or Profound Intellectual Disability: A Qualitative Descriptive Study
Authors: Hanley Edina , Dalton Caroline , Lehane Elaine , Martin Anne‐Marie 
Published: September 2024

ABSTRACTBackgroundThis study explores communication partners' perceptions of their roles and responsibilities in the design, planning and use of augmentative and alternative communication (AAC) with individuals with severe/profound intellectual disability.MethodsA qualitative descriptive approach was used. Purposive sampling, data collection and qualitative content analysis were undertaken simultaneously. Data were collected from nine participants, four parents and five professionals over 4 months through audio or video‐recorded, semi‐structured, open‐ended interviews.FindingsAn overarching theme ‘Maximising Communication through AAC’ emerged, capturing participants' unanimous agreement that their shared goal was to optimise individuals' communication through AAC. This was influenced by three themes: ‘Developing a Communicative Environment’, ‘The Act of Communicating; Attempting to Realise the Individuals' Ability’ and ‘Living with Uncertainty’.ConclusionsThese findings contribute to enhancing understanding of AAC use with individuals with severe/profound intellectual disability and their communication partners.
Mitigating off‐target effects of small RNAs: conventional approaches, network theory and artificial intelligence
Authors: Bereczki Zoltán , Benczik Bettina , Balogh Olivér M. , Marton Szandra , Puhl Eszter , Pétervári Mátyás , Váczy‐Földi Máté , Papp Zsolt Tamás , Makkos András , Glass Kimberly , Locquet Fabian , Euler Gerhild , Schulz Rainer , Ferdinandy Péter , Ágg Bence 
Published: September 2024

AbstractThree types of highly promising small RNA therapeutics, namely, small interfering RNAs (siRNAs), microRNAs (miRNAs) and the RNA subtype of antisense oligonucleotides (ASOs), offer advantages over small‐molecule drugs. These small RNAs can target any gene product, opening up new avenues of effective and safe therapeutic approaches for a wide range of diseases. In preclinical research, synthetic small RNAs play an essential role in the investigation of physiological and pathological pathways as silencers of specific genes, facilitating discovery and validation of drug targets in different conditions. Off‐target effects of small RNAs, however, could make it difficult to interpret experimental results in the preclinical phase and may contribute to adverse events of small RNA therapeutics. Out of the two major types of off‐target effects we focused on the hybridization‐dependent, especially on the miRNA‐like off‐target effects. Our main aim was to discuss several approaches, including sequence design, chemical modifications and target prediction, to reduce hybridization‐dependent off‐target effects that should be considered even at the early development phase of small RNA therapy. Because there is no standard way of predicting hybridization‐dependent off‐target effects, this review provides an overview of all major state‐of‐the‐art computational methods and proposes new approaches, such as the possible inclusion of network theory and artificial intelligence (AI) in the prediction workflows. Case studies and a concise survey of experimental methods for validating in silico predictions are also presented. These methods could contribute to interpret experimental results, to minimize off‐target effects and hopefully to avoid off‐target‐related adverse events of small RNA therapeutics.LINKED ARTICLESThis article is part of a themed issue Non‐coding RNA Therapeutics. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v182.2/issuetoc
The role of focused attention in learning from early childhood to late adolescence: Implications of neonatal brainstem compromise following preterm birth
Authors: Burstein Or , Sabag Maya , Kurtzman Lea , Geva Ronny 
Published: September 2024

AbstractThis comprehensive longitudinal study explored for the first time the interrelations between neonatal brainstem abnormalities, focused attention (FA), and learning—following a preterm cohort (N = 175; 46.3% female; predominantly White) from birth (2003–2006) to 17 years. The findings indicated that FA during early childhood was associated with language outcomes in toddlerhood (n = 131) and academic and attention self‐report indices in late adolescence (n = 44). Pilot assessments indicated that FA at 17 years (n = 25) was also associated with concurrent academic and attention functioning. Structural equation modeling analyses revealed that neonatal brainstem functioning, manifested in auditory brainstem response patterns, was associated with early‐life FA competence, which affected learning development. Implications underscore the essential role of early brainstem function and FA in shaping childhood learning trajectories.
Knowledge and perceptions about fragile X syndrome and fragile X‐premutation‐associated conditions among medical doctors in Nigeria
Authors: Mbachu Chioma N. P. , Hagerman Randi , Eseigbe Edwin , Odita Amalachukwu , Mbachu Ikechukwu , Ilikanu Samuel , Akowundu Kasarachi , Ndukwu Chizalu , Echezona Malachy , Okereke Onyedikachi , Echendu Sylvia , Udigwe Ifeoma 
Published: September 2024

AbstractFragile X syndrome (FXS) is a significant cause of intellectual disability and autism, while Fragile X Premutation ‐Associated Conditions (FXPAC) are a significant cause of morbidity and mortality globally. This study assessed the level of knowledge and perceptions about FXS and FXPAC among doctors in Nigeria. It was a web‐based, cross‐sectional study conducted among a cohort of doctors in Nigeria. Socio‐demographic profile, knowledge of FXS, perceptions about FXS, knowledge of FXPAC, experience of doctors, and suggested ways of improving knowledge and management of FXS were obtained. Data were analyzed using STATA 16.0. Chi‐square and Fisher's exact tests of association were used to determine the association between variables, with the significance level set at p < 0.05. A total of 274 doctors participated in the study. A significant proportion of respondents had limited knowledge about the clinical features of FXS. Nine of ten (90.0%) participants with good knowledge of FXS had good perceptions of FXS management. This was statistically significant (p < 0.001). There was a high nonresponse rate to what FXPAC is (164/274, 59.9%) among the respondents because of insufficient knowledge. Suboptimal knowledge of FXS which influenced perception was noted among doctors. More strategies should be considered to improve doctors' knowledge and management of FXS and FXPAC in Nigeria.
Are population policies in Arab countries largely ineffective? Past and present perspectives
Authors: Nadan Amos 
Published: September 2024

AbstractThis essay explores two types of population policies common in Arab countries: pro‐natalist policies, aimed at encouraging higher birth rates, and anti‐natalist policies, aimed at reducing birth rates. Determining their practical impact is often challenging due to the lack of control or comparison groups. However, historical policy patterns in two groups of Arab countries over the past six decades offer a unique opportunity for comparison. Between the 1970s and 1990s these two groups implemented opposing programs (pro‐ vs. anti‐natalist), followed by predominantly anti‐natalist policies in both groups. By comparing fertility rates between these groups and discussing various factors influencing fertility changes, this study suggests that the influence of population policies in Arab countries may have been smaller than anticipated, to the point that it is questionable whether they have been worthwhile.
Evidence‐based neuroprotective potential of nonfeminizing estrogens: In vitro and in vivo studies
Authors: Bansal Seema , Swami Rajan , Bansal Nitin , Chaudhary Rishabh , Mahendiratta Saniya , Kaur Harpreet , Chopra Kanwaljit , Medhi Bikash 
Published: September 2024

AbstractMenopause weakens the brain's structural integrity and increases its susceptibility to a range of degenerative and mental illnesses. 17β estradiol (17βE2) exhibits potent neuroprotective properties. Exogenous estrogen supplementation provides neuroprotection, but the findings presented by the Million Women Study (MWS) and the Women's Health Initiative (WHI), as well as the increased risk of endometrial cancer, breast cancer and venous thromboembolism associated with estrogen use, have cast doubt on its clinical use for neurological disorders. Thus, the objective of our review article is to compile all in vitro and in vivo studies conducted till date demonstrating the neuroprotective potential of nonfeminizing estrogens. This objective has been achieved by gathering various research and review manuscripts from different records such as PubMed, Embase, Scopus, Google Scholar, Web of Science and OVID, using different terms like ‘estrogen deficiency, 17β estradiol, non‐feminising estrogens, and brain disorder’. However, recent evidence has revealed the contribution of numerous non‐estrogen receptor‐dependent pathways in neuroprotective effects of estrogen. In conclusion, synthetic nonfeminizing estrogens that have little or no ER binding but are equally powerful (and in some cases more potent) in delivering neuroprotection are emerging as viable and potential alternatives.
Land use drives the distribution of free, physically protected, and chemically protected soil organic carbon storage at a global scale
Authors: Willard Samuel J. , Liang Guopeng , Adkins Savannah , Foley Karen , Murray Jessica , Waring Bonnie 
Published: September 2024

AbstractSoil organic carbon (SOC) sequestration is increasingly emphasized as a climate mitigation solution, as scientists, policy makers, and land managers prioritize enhancing belowground C storage. To identify key underlying drivers of total SOC distributions, we compiled a global dataset of soil C stocks held in three chemical forms, reflecting different mechanisms of organic C protection: free particulate organic C (fPOC), physically protected particulate organic C (oPOC), and mineral‐protected soil organic C (mSOC). In our dataset, these three SOC pools were differentially sensitive to the effects of climate, soil mineralogy, and ecosystem type, emphasizing the importance of distinguishing between physical and chemical C protection mechanisms. C stocks in all three pools varied among ecosystems: cropland soils stored the least amount in each pool, with forest and grassland soils both containing significantly more fPOC (40%–60% greater in each ecosystem) than croplands. oPOC stocks did not significantly differ from zero in croplands but were substantial in forest and grassland soils. Meanwhile, mSOC stocks were the greatest in grasslands and shrublands (90%–100% greater than croplands). In cropland soils, there were no major effects of tillage on C storage in any of the three pools, while manure addition enhanced mSOC stocks, especially when added with inorganic N. Thus, the human land use intensity in croplands appears to reduce SOC storage in all major pools, depending upon management; retaining native vegetation should be emphasized to maintain current global SOC stocks.
Pathogenesis of osteoarthritis, rheumatoid arthritis, and hemophilic arthropathy: The role of angiogenesis
Authors: Caliogna Laura , Berni Micaela , Torriani Camilla , Mancuso Maria Elisa , Di Minno Matteo Nicola Dario , Brancato Alice Maria , Jannelli Eugenio , Mosconi Mario , Pasta Gianluigi 
Published: September 2024

AbstractIntroductionThe term ‘chronic inflammatory arthritis’ (IA) can be used to define a group of heterogeneous diseases in which inflammation of the synovium is the common feature while having different pathogenesis and clinical outcomes. This condition can be found in osteoarthritis (OA), rheumatoid arthritis (RA), and hemophilic arthropathy (HA).AimThe objective is to try to highlight similarities and differences in the three pathological conditions and understand both molecular and physiological mechanisms.MethodWe have carried out a systematic review of the available literature following the guidelines Preferred Reporting Items for Systematic Reviews and Meta‐analysis (PRISMA).ResultsBy comparing the data in the literature on OA, RA, and HA we have shown that the three pathologies differ in initial etiology but they motivate the same molecular pathways.ConclusionIn this review we highlighted the similarities and differences between these diseases, creating ideas for future studies both in vivo and in vitro to develop new therapeutic agents and suggest possible biomarkers to follow the evolution and severity of the disease.
Improvement of BGO ceramic scintillators through hot‐pressing sintering methodology
Authors: Matos Ivus L. O. , Andrade Adriano B. , Batista Joana S. B. , Lilge Tatiane S. , Macedo Zélia S. , Valerio Mário E. G. 
Published: September 2024

AbstractIn the present work, the sintering of bismuth germanate through hot pressing and the improvement of scintillator performance were investigated. The linear shrinkage, crystalline structure, microstructure, transparency degree, and radioluminescence (RL) were studied as functions of the sintering pressure. X‐ray diffraction revealed that the samples were predominantly composed of the Bi4Ge3O12 phase, accompanied by small amounts of Bi12GeO20, with concentrations varying according to the sintering parameters. These concentrations were quantified through Rietveld refinement, which also indicated a tendency for the cell parameters to shrink as the sintering pressure increased. The microstructure of the ceramic pellets produced under varying hot‐pressing parameters was investigated using scanning electron microscopy (SEM), revealing that while the grain size was preserved, the porosity and grain boundary thickness were reduced by the hot pressing, forming a quasicontinuum in some areas of the sample. The RL of all the samples exhibited a green color, with a maximum at 540 nm, ascribed to the transitions from the 3P0,1,21P1 excited states to the fundamental 1S0 state of the Bi3+ ions. For samples sintered under a pressure of .18 MPa, the enhancement in the optical transmittance, accompanied by a 61.36% increase in light output at the maximum wavelength, was observed.