bluuebunny/crossref_metadata_2025_split huggingface dataset:
Using the Second-Generation GEFS Reforecasts to Predict Ceiling, Visibility, and Aviation Flight Category
Authors: Verlinden Kathryn L. , Bright David R. 
Published: August 2017

Abstract
This study is an aviation-based application of NOAA’s second-generation medium-range Global Ensemble Forecast System Reforecast (GEFS/R; i.e., hindcast or retrospective forecast) dataset. The study produced a downscaled probabilistic prediction of instrument flight conditions at major U.S. airports using an analog approach. This represents an initial step toward applications of reforecast data to probabilistic aviation decision support services. Results from this study show that even at the very coarse resolution of the GEFS/R dataset, the analog approach yielded skillful probabilistic forecasts of flight conditions (i.e., instrument flight rules vs visual flight rules) at most of the Federal Aviation Administration (FAA)’s Core 30 airports. This was particularly true over the central and eastern United States, including the important Golden Triangle, where aircraft flow affects traffic flow management across the entire national airspace system. Additionally, the results suggest that reforecast systems utilizing better horizontal and vertical resolution, in both the modeling system and the reforecast archive, would be very useful for aviation forecasting applications.
Screening for Malnutrition Among People Accessing Health Services at Greek Public Hospitals: Results From an Observational Multicenter Study
Authors: Doundoulakis Ioannis , Poulia Kalliopi Anna , Antza Christina , Bouras Emmanouil , Kasapidou Eirini , Klek Stanislaw , Chourdakis Michael 
Published: August 2017

AbstractBackgroundMalnutrition is associated with increased hospital stay and subsequently higher healthcare costs. Early detection of malnutrition among people accessing health services at public hospitals is vital to identify and treat malnutrition effectively and in a timewise and cost‐effective manner. The aim of this study was to evaluate the nutrition risk of this population.Materials and MethodsNutrition screening was performed for 2970 patients (52% male; 55.3 ± 20.1 years old) at 34 hospitals. Nutrition risk was evaluated through 3 nutrition screening tools—Nutritional Risk Screening 2002 (NRS‐2002), Malnutrition Universal Screening Tool (MUST), and Mini Nutritional Assessment‐Screening Form (MNA‐SF).
ResultsMalnutrition risk was found: 25.3% with NRS‐2002, 22.9% with MUST, and 60.5% with MNA‐SF. Nutrition risk among patients accessing health services at public hospitals increases with age (high‐risk patients among those ≥80 years old: NRS‐2002, 9.8%; MUST, 16.9%; MNA‐SF, 43.9%). The highest prevalence of nutrition risk was found at the oncology departments (16.7%, NRS‐2002; 23.4%, MUST). According to the NRS‐2002 and MUST, surgical patients have a greater risk for malnutrition vs internal medicine patients (adjusted odds ratio [OR] = 1.0, P < .001; adjusted OR = 1.17, P < .001, respectively), whereas according to MNA‐SF, surgical patients have 30% lower probability for malnutrition risk against internal medicine patients (adjusted OR = 0.7, P < .001).ConclusionsA high prevalence of malnutrition risk was reported among patients accessing health services at public hospitals. Early detection of malnutrition is vital to allow the allocation of the needed workforce to manage it effectively.
Hippotherapy for patients with multiple sclerosis: A multicenter randomized controlled trial (MS-HIPPO)
Authors: Vermöhlen Vanessa , Schiller Petra , Schickendantz Sabine , Drache Marion , Hussack Sabine , Gerber-Grote Andreas , Pöhlau Dieter 
Published: August 2017

Background: Evidence-based complementary treatment options for multiple sclerosis (MS) are limited. Objective: To investigate the effect of hippotherapy plus standard care versus standard care alone in MS patients. Methods: A total of 70 adults with MS were recruited in five German centers and randomly allocated to the intervention group (12 weeks of hippotherapy) or the control group. Primary outcome was the change in the Berg Balance Scale (BBS) after 12 weeks, and further outcome measures included fatigue, pain, quality of life, and spasticity. Results: Covariance analysis of the primary endpoint resulted in a mean difference in BBS change of 2.33 (95% confidence interval (CI): 0.03–4.63, p = 0.047) between intervention ( n = 32) and control ( n = 38) groups. Benefit on BBS was largest for the subgroup with an Expanded Disability Status Scale (EDSS) ⩾ 5 (5.1, p = 0.001). Fatigue (−6.8, p = 0.02) and spasticity (−0.9, p = 0.03) improved in the intervention group. The mean difference in change between groups was 12.0 ( p < 0.001) in physical health score and 14.4 ( p < 0.001) in mental health score of Multiple Sclerosis Quality of Life-54 (MSQoL-54). Conclusion: Hippotherapy plus standard care, while below the threshold of a minimal clinically important difference, significantly improved balance and also fatigue, spasticity, and quality of life in MS patients.
Efficacy of tele-rehabilitation compared with office-based physical therapy in patients with knee osteoarthritis: A randomized clinical trial
Authors: Azma Kamran , RezaSoltani Zahra , Rezaeimoghaddam Farid , Dadarkhah Afsaneh , Mohsenolhosseini Sarasadat 
Published: August 2017

Introduction Knee osteoarthritis is a major cause of disability among the middle to senior age groups. Despite being effective, office-based physical therapy (OBPT) needs professional human resources and is both costly and time-consuming. We aimed to compare the efficacy of tele-rehabilitation (tele-rehab) compared with OBPT in patients with knee osteoarthritis. Methods In this randomized clinical trial, patients with symptomatic osteoarthritis of the knee were assigned to participate in either a 6-week home-based tele-rehab or an OBPT program between 2015 and 2016. Our primary outcome was the mean change from the baseline until 1 and 6 month's post-intervention in scores of the Knee injury and Osteoarthritis Outcome Score (KOOS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). We used analysis of variance for the repeated measure statistical test. Results A total of 54 patients entered the final analysis, with 27 in each group. The mean age of the patients was 58.2 ± 7.41 years and 60.2% were female. In the tele-rehab and OBPT group, KOOS scores increased from baseline to 6 months post-intervention (50.6 to 83.1 and 49.8 to 81.8) respectively. There was no significant difference between tele-rehab and OBPT groups in any of the studied scales. Discussion The tele-rehab program is as effective as OBPT in improving the function of patients with knee osteoarthritis. Considering the much lower time and cost consumed by tele-rehab, it is the recommended program for the older population living in remote sites.
Distal radius fractures – A volar plate is not just a volar plate
Authors: Knight Richard , Elliott Lucy , Brewster Mark , Spiteri Michelle , Power Dominic 
Published: August 2017

Introduction Increasingly complex distal radius plate designs are available for treating distal radius fractures. As a result, many fractures are being ‘over-treated’ with more complex volar plate designs than necessary. We hypothesise that significant cost savings could be made by rationalising the use of complex locking plate designs. Methods Over a two-year period, radiographs of 250 consecutive distal radius fractures fixed with volar locking plates were reviewed and the type of plate, and type and number of screws used for fixation were noted. Preoperative radiographs were independently reviewed to ascertain if it would have been possible to stabilise the fracture with a simpler, extra-articular plate design. Potential cost savings were then calculated. Results It was deemed that 89 (36.5%) of the 250 cases originally treated with a more complex 2 column variable angle plate could have been treated with an extra-articular construct, leading to potential savings of £19,224. Conclusion It is clear from our data that many distal radius fracture patterns are being ‘over-treated’ with complex locking plate designs with multiple rows of screws and that substantial cost savings could be made by selecting an appropriate construct to suit the fracture pattern.
Clinicians' perspectives on the duty of candour: Implications for medical ethics education
Authors: Fowler George E , Vivekananda-Schmidt Pirashanthie 
Published: August 2017

Content Truth-telling is an integral part of medical practice in many parts of the world. However, recent public inquiries, including the Francis Inquiry reveal that a duty of candour in practise, are at times compromised. Consequently, the duty of candour became a statutory requirement in England. This study aimed to explore clinicians’ perspectives of the implications of the legislation for medical ethics education, as raising standards to improve patient safety remains an international concern. Methods One-to-one interviews with clinical educators from various specialties who contribute to the MBChB programme at the authors’ university. Once data saturation had been assessed, transcripts were analysed using a thematic approach by the following concurrent activities: data reduction and coding into themes. Example quotations are used to illustrate that key themes are grounded in the data. Results Eleven clinical educators were interviewed; three general practitioners, six physicians and two surgeons. Thematic analysis identified three key themes; reaction to legislation, barriers to implementation and areas of the medical curriculum that can be further developed to better prepare future doctors. Conclusions Currently, the legislation is not reaching all frontline staff; there remains a lack of appropriate training and teaching on the legislation that responds to the perceived challenges to implementing candour. These challenges include tensions in the clinical workplace and concerns about the patient’s best interests conflicting with requirements of the legislation. Both undergraduate and postgraduate curricula need to integrate teaching on the implications of the legislation and take a practice based approach in doing so.
Organ Donation Registration and Decision-Making Among Current Blood Donors in the Netherlands
Authors: Merz Eva-Maria , van den Hurk Katja , de Kort Wim L.A.M. 
Published: August 2017

Introduction: In the Netherlands, there is a constant shortage in donor organs, resulting in long waiting lists. The decision to register as organ donor is associated with several demographic, cultural, and personal factors. Previous research on attitudes and motivations toward blood and organ donations provided similar results. Research Question: The current study investigated demographic, cultural, and personal determinants of organ donation registration among current Dutch blood donors. Design: We used data from Donor InSight (2012; N = 20 063), a cohort study among Dutch blood donors, to test whether age, gender, religious and political preferences, donor attitude, and altruism predicted organ donor registration among current blood donors. Results: Organ donors were more often represented in the blood donor population compared to the general Dutch population. Women showed a higher propensity to be registered as organ donor. Higher education as well as higher prosocial value orientation, prosocial behavior, that is, doing volunteer work, and awareness of need significantly associated with being registered as organ donor. Religious denomination negatively predicted organ donation registration across all faiths. Discussion: Results are discussed in light of cultural context, and possible implications for improving information provision and recruitment are mentioned.
A Department of Motor Vehicle–Based Intervention to Promote Organ Donor Registrations in New York State
Authors: Feeley Thomas Hugh , Anker Ashley E. , Evans Melanie , Reynolds-Tylus Tobias 
Published: August 2017

Context: Examination of efficacy of motor vehicle representative educational training and dissemination of promotional materials as a means to promote organ donation enrollments in New York State. Objective: To increase the number of New York State residents who consent to donation through the department of motor vehicle transactions during project period. Setting: County-run motor vehicle offices across New York State. Participants: Customers who present to New York Department of Motor Vehicle offices and the representative who work at designated bureaus. Interventions: point-of-decision materials including promotional posters, brochures, website, and the motor vehicle representative training sessions. Main Outcome Measures: Reasons for enrollment decision, knowledge/experience with donation, monthly consent rates, enrollment in state organ, and tissue registry. Results: Customers who elected not to register reported no reason or uncertainty surrounding enrollment. The representatives reported experience with donation, discussion with customers, and need for additional education on organ donation. Enrollment cards were mailed to 799 project staff; counties where offices participated in intervention did not indicate significantly higher monthly enrollments when comparing pre- to postenrollment rates. Conclusions: Use of point-of-decision materials and enrollment cards proved inexpensive method to register customers with a 3.6% return rate. Customers report low (27%) enrollment rate and reticence to consent to donation. Educational training sessions with representatives did not yield significant enrollment increases when evaluating data at county-level enrollment.
A sonographic Doppler study of the hepatic vein, portal vein and hepatic artery in liver cirrhosis: Correlation of hepatic hemodynamics with clinical Child Pugh score in Singapore
Authors: Afif Azizah M , Chang Jason Pik-Eu , Wang Yan Y , Lau Simin D , Deng Fuzhen , Goh Shy Y , Pwint Mar K , Ooi Chin C , Venkatanarasimha Nanda , Lo Richard HG 
Published: August 2017

Objective Liver cirrhosis has been a rising complication of chronic liver disease in Singapore. Ultrasound has been widely accepted as a non-invasive imaging modality for the evaluation of hepatic haemodynamics. This study aims to correlate the Doppler ultrasound values with the progression of liver cirrhosis to allow further understanding and possible prediction of clinical events for timely intervention. Methods Study sample of 56 eligible patients with liver cirrhosis was divided according to their Child-Pugh clinical score into Child’s A (n = 29 patients), B (n = 19 patients) and C (n = 8 patients). The maximum portal vein velocity, maximum hepatic vein velocity, maximum hepatic artery velocity and hepatic artery resistive index were assessed by Doppler ultrasound. Results The incidence of ascites increases with the severity of cirrhosis. Flattening of the hepatic vein waveforms was dependant on degree of liver cirrhosis. Maximum hepatic vein velocity was higher in cirrhotic patients (where p = 0.05). Maximum portal vein velocity was found to be lower in cirrhosis (where p < 0.001) and mean maximum portal vein velocity decreases as severity of cirrhosis worsens. Hepatic artery resistive index was significantly higher in cirrhosis (where p < 0.001). Significant association was found between maximum hepatic vein velocity and maximum hepatic artery velocity and significant negative correlation was observed with the maximum portal vein velocity and hepatic artery resistive index. Conclusion The study demonstrated that these parameters can supplement the evaluation of liver cirrhosis and will be able to distinguish the different grades of liver cirrhosis using Doppler ultrasound.
How mental health service systems are organized may affect the rate of acute admissions to specialized care: Report from a natural experiment involving 5338 admissions
Authors: Myklebust Lars Henrik , Sørgaard Knut , Wynn Rolf 
Published: August 2017

Objectives: Studies on the dynamics between service organization and acute admissions to psychiatric specialized care have given ambiguous results. We studied the effect of several variables, including service organization, coercion, and patient characteristics on the rate of acute admissions to psychiatric specialist services. In a natural experiment-like study in Norway, we compared a “deinstitutionalized” and a “locally institutionalized” model of mental health services. One had only community outpatient care and used beds at a large Central Mental Hospital; the other also had small bed-units at the local District Psychiatric Centre. Methods: From the case registries, we identified a total of 5338 admissions, which represented all the admissions to the psychiatric specialist services from 2003 to 2006. The data were analyzed with chi-square tests and Z-tests. In order to control for possible confounders and interaction effects, a multivariate analysis was also performed, with a logistic regression model. Results: The use of coercion emerged as the strongest predictor of acute admissions to specialist care (odds ratio = 7.377, 95% confidence interval = 4.131–13.174) followed by service organization (odds ratio = 3.247, 95% confidence interval = 2.582–4.083). Diagnoses of patients predicted acute admissions to a lesser extent. We found that having psychiatric beds available at small local institutions rather than beds at a Central Mental Hospital appeared to decrease the rate of acute admissions. Conclusion: While it is likely that the seriousness of the patients’ condition is the most important factor in doctors’ decisions to refer psychiatric patients acutely, other variables are likely to be important. This study suggests that the organization of mental health services is of importance to the rate of acute admissions to specialized psychiatric care. Systems with beds at local District Psychiatric Centers may reduce the rate of acute admissions to specialized care, compared to systems with local community outpatient services and beds at Central Mental Hospitals.
Perceptıon scale of barrıers to contraceptıve use: a methodologıcal study
Authors: Sen Selma , Cetinkaya Aynur , Cavuslar Aysel 
Published: August 2017

Abstract
Background
The objective of this study was to design and develop the Perception Scale of Barriers to Contraceptive Use (PSBCU) as a measurement tool for the qualitative assessment of the barriers and obstacles women perceived with regard to contraceptive use or low rates of contraceptive use in women using family planning services.

Method
The data for this methodological study were collected using the face-to-face interview technique from 320 married women between the ages of 15-49 who were attending clinics at the Hafsa Sultan Hospital, CBU. The data collection tools used in the study, which was carried out from May to September 2014, were the “Introductory Information Form” and the “Perception Scale of Barriers to Contraceptive Use”. Language validity and construct validity (explanatory factor analysis) were applied in order to test the validity of the Perception Scale of Barriers to Contraceptive Use.

Results
Kaiser Meier Olkin (KMO) analysis was performed to determine the availability of the scale for the size of participants. The sample adequacy calculated as the KMO value was 0.916 and the Bartlett’s Test of Sphericity (X2 = 6721.793 p < 0.000) sample size analysis value was found to be sufficient for factor analysis. The total Cronbach’s Alpha coefficient of 34 items which included three factors explaining 54.95% of the variance after Varimax rotation was calculated to be 0.95. The largest factor was the “cognitive domain” explaining 18.89% of the variance, followed by the “emotional domain” explaining 18.05% of the variance, and finally the “social domain” explaining 18.01% of the variance. Item-total score correlation coefficients of scale items were found to be between 0.54 and 0.83.

Conclusions
The study demonstrateded that the “Perception Scale of Barriers to Contraceptive Use” was valid and reliable. We believe that the scale is suitable for use by women in a family planning education and training programs in order to evaluate their situation. It should also be assessed for validity and reliability for different groups (adolescents, men, etc.).
Identification of compounds that decrease numbers of Mycobacteria in human macrophages in the presence of serum amyloid P
Authors: Xiang Wang , Cox Nehemiah , Gomer Richard H 
Published: August 2017

Abstract
Mϕs are a heterogeneous population of cells and include classically activated Mϕs (M1) and alternatively activated Mϕs (M2). Mϕs can change from M1 to M2 and vice versa in response to environmental stimuli. Serum amyloid P (SAP) is a constitutive plasma protein that polarizes Mϕs to an M2 phenotype, and part of this effect is mediated through FcγRI receptors. In an effort to find ways to alter Mϕs phenotypes, we screened for compounds that can block the SAP–FcγRI interaction. From a screen of 3000 compounds, we found 12 compounds that reduced the ability of fluorescently labeled human SAP to bind cells expressing human FcγRI. Based on cell surface marker expression, 8 of the compounds inhibited the effect of SAP on skewing human Mϕs to an M2 phenotype and in the presence of SAP polarized Mϕs to an M1 phenotype. In diseases, such as tuberculosis, M1s are more effective at killing bacteria than M2s. SAP potentiated the numbers of the mycobacterial strains Mycobacterium smegmatis and Mycobacterium tuberculosis in Mϕs. When added along with SAP, 2 of the compounds reduced intracellular Mycobacterium numbers. Together, these results indicate that the blocking of SAP effects on Mϕs can skew these cells toward an M1 phenotype, and this may be useful in treating diseases, such as tuberculosis.
Milton, Modernity, and the Periodization of Politics
Authors: Morrissey Lee 
Published: August 2017

Abstract
Periodized “modernity” unnecessarily polarizes Milton’s reception. His experience of modernity in the seventeenth century confounds the Enlightenment distinctions usually made about modernity. The periodized idea of modernity that continues to shape the study of Milton is dated, even antiquated, because it is treated as a period. It seems as if a generation has learned to read Restoration poetry through Dryden, and from Dryden to assume that poetry published during the Restoration must be poetry about the Restoration. Milton does not read his sources the way that periodizing scholarship has been reading his poetry. Readers can approach Milton’s works as he approached his earlier sources: to see what they might offer our understanding of events in our contexts, that is, anachronistically. Reading anachronistically is, after all, one of the principal advantages and pleasures of fiction, of literary study, and of metaphor. The alternative to what has been called “the poverty of context” is the richness and variety of poetic contexts, understood diachronically.