bluuebunny/crossref_metadata_2025_split huggingface dataset:
When tense meets constructional meaning
Authors: Kiyama Naoki 
Published: September 2017

AbstractConstruction Grammar, one of the major frameworks in Cognitive Linguistics, has been successful in providing accounts of a wide range of empirical data. The approach has recently placed great emphasis on low-level generalizations, and some studies have argued that a constructional meaning is often associated only with a specific lexical item. Therefore, by investigating in detail the form [copulabe+ Adj. +enough+to-infinitive], the present study proposes that the combinatorial potential of the intensifierenoughand the derived constructional meanings are sensitive to tense, thus emphasizing the importance of ‘item- and tense-specific constructions’.
Radiation-pressure-driven sub-Keplerian rotation of the disc around the AGB star L2Pup
Authors: Haworth Thomas J. , Booth Richard A. , Homan Ward , Decin Leen , Clarke Cathie J. , Mohanty Subhanjoy 
Published: September 2017

AbstractWe study the sub-Keplerian rotation and dust content of the circumstellar material around the asymptotic giant branch (AGB) star L2 Puppis. We find that the thermal pressure gradient alone cannot explain the observed rotation profile. We find that there is a family of possible dust populations for which radiation pressure can drive the observed sub-Keplerian rotation. This set of solutions is further constrained by the spectral energy distribution (SED) of the system, and we find that a dust-to-gas mass ratio of ∼10−3 and a maximum grain size that decreases radially outwards can satisfy both the rotation curve and SED. These dust populations are dynamically tightly coupled to the gas azimuthally. However, grains larger than ∼ 0.5 μm are driven outwards radially by radiation pressure at velocities ∼5 km s−1, which implies a dust replenishment rate of ∼3 × 10−9 M⊙ yr−1. This replenishment rate is consistent with observational estimates to within uncertainties. Coupling between the radial motion of the dust and gas is weak and hence the gas does not share in this rapid outward motion. Overall, we conclude that radiation pressure is a capable and necessary mechanism to explain the observed rotation profile of L2 Pup, and offers other additional constraints on the dust properties.
The Role of Cognitive Content and Cognitive Processes in Chronic Pain
Authors: Jensen Mark P. , Thorn Beverly E. , Carmody James , Keefe Francis J. , Burns John W. 
Published: September 2017

Objectives:
Pain-related cognitive content (what people think about pain) and cognitive processes (how people think about pain; what they do with their pain-related thoughts) and their interaction are hypothesized to play distinct roles in patient function. However, questions have been raised regarding whether it is possible or practical to assess cognitive content and cognitive process as distinct domains. The aim of this study was to determine the extent to which measures that seem to assess mostly pain-related cognitive content, cognitive processes, and content and process, are relatively independent from each other and contribute unique variance to the prediction of patient function.

Materials and Methods:
Individuals with chronic low back pain (N=165) participating in an ongoing RCT were administered measures of cognitions, pain, and function (depressive symptoms and pain interference) pretreatment.

Results:
Analyses provided support for the hypothesis that cognitive content and cognitive process, while related, can be assessed as distinct components. However, the measure assessing a cognitive process—mindfulness—evidenced relatively weak associations with function, especially compared with the stronger and more consistent findings for the measures of content (catastrophizing and self-efficacy).

Discussion:
The results provide preliminary evidence for the possibility that mindfulness could have both benefits and costs. Research to evaluate this possibility is warranted.
Exploration of Quantitative Sensory Testing in Latent Trigger Points and Referred Pain Areas
Authors: Ambite-Quesada Silvia , Arias-Buría José L. , Courtney Carol A. , Arendt-Nielsen Lars , Fernández-de-las-Peñas César 
Published: September 2017

Objective:
The objective of this study was to investigate somatosensory nerve fiber function by applying different quantitative sensory testing including thermal, mechanical, and vibration thresholds over latent trigger points (TrP) and in its associated referred pain area.

Methods:
A total of 20 patients with unilateral latent TrPs in the extensor carpi radialis brevis were included. Warmth detection threshold (WDT), cold detection threshold (CDT) and heat/cold pain thresholds (HPT, CPT), mechanical detection (MDT) and pain (MPT) thresholds, vibration threshold (VT), and pressure pain thresholds (PPT) were blinded assessed over the TrP, in the referred pain area, and in the respective contralateral mirror areas. A multilevel mixed-model ANOVA with site (TrP, referred pain area) and side (real or contralateral) as within-patient factors and sex as between-patients factor was conducted.

Results:
No significant differences for thermal detection (WDT, CDT) or thermal pain thresholds (HPT, CPT) were found (all, Ps>0.141). The assessments over the TrP area showed lower PPT and MDT compared with the mirror contralateral TrP area (P<0.05). MDT were higher (P=0.001) but PPT (P<0.001) and MPT (P=0.032) were lower over the TrP area and contralateral mirror point compared with their respectively referred pain areas. Finally, VT was higher over the TrP area than in the referred pain area and over both mirror contralateral points.

Discussion:
Assessing sensory changes over latent myofascial TrPs reveal mechanical hyperesthesia, pressure pain hyperalgesia, and vibration hypoesthesia compared with a contralateral mirror area.
Fatigue Following Traumatic Brain Injury in Children and Adolescents: A Longitudinal Follow-Up 6 to 12 Months After Injury
Authors: Crichton Alison , Anderson Vicki , Oakley Ed , Greenham Mardee , Hearps Stephen , Delzoppo Carmel , Beauchamp Miriam H. , Hutchison James S. , Guerguerian Anne-Marie , Boutis Kathy , Babl Franz E. 
Published: September 2017

Background:
Longitudinal fatigue data in children suffering from traumatic brain injury (TBI) are lacking.

Objectives:
To examine the effects of time postinjury (6-12 months) and injury severity on fatigue after childhood TBI. Secondarily, we compared fatigue 12 months postinjury against published control data.

Setting:
Three tertiary children's hospitals across Australia (n = 1) and Canada (n = 2).

Participants:
Parents (n = 109) of children (mean [M] = 9.9 years at injury; range, 1.0-16.9 years) admitted to one of 3 participating hospitals with mild (n = 69) or moderate/severe (n = 37) TBI.

Design:
Longitudinal prospective study.

Measures:

Primary: Pediatric Quality of Life Multidimensional Fatigue Scale (total, general, sleep/rest, and cognitive), rated by parents 6 and 12 months postinjury. Secondary: Pediatric Injury Functional Outcome Scale (fatigue and sleep items, rated on recruitment and 6 and 12 months postinjury). Demographic and children data were collected at recruitment.

Results:
Mixed-models analysis demonstrated nonsignificant effects of time (6 vs 12 months postinjury) on multidimensional fatigue scores. Cognitive fatigue worsened over time. Moderate/severe TBI was associated with worse fatigue 12 months postinjury (general, P = .03; cognitive, P = .02). Across all severities, fatigue 12 months postinjury was significantly worse compared with control data (total fatigue, P < .001; all domains, all Ps < .025).

Conclusion:
Fatigue remains significant at 12 months since injury, particularly for those with moderate/severe TBI.
Using Functional Magnetic Resonance Imaging to Detect Chronic Fatigue in Patients With Previous Traumatic Brain Injury: Changes Linked to Altered Striato-Thalamic-Cortical Functioning
Authors: Berginström Nils , Nordström Peter , Ekman Urban , Eriksson Johan , Andersson Micael , Nyberg Lars , Nordström Anna 
Published: September 2017

Objective:
To investigate whether functional magnetic resonance imaging (fMRI) can be used to detect fatigue after traumatic brain injury (TBI).

Setting:
Neurorehabilitation clinic.

Participants:
Patients with TBI (n = 57) and self-experienced fatigue more than 1 year postinjury, and age- and gender-matched healthy controls (n = 27).

Main Measures:
Self-assessment scales of fatigue, a neuropsychological test battery, and fMRI scanning during performance of a fatiguing 27-minute attention task.

Results:
During testing within the fMRI scanner, patients showed a higher increase in self-reported fatigue than controls from before to after completing the task (P < .001). The patients also showed lower activity in several regions, including bilateral caudate, thalamus, and anterior insula (all P < .05). Furthermore, the patients failed to display decreased activation over time in regions of interest: the bilateral caudate and anterior thalamus (all P < .01). Left caudate activity correctly identified 91% of patients and 81% of controls, resulting in a positive predictive value of 91%.

Conclusion:
The results suggest that chronic fatigue after TBI is associated with altered striato-thalamic-cortical functioning. It would be of interest to study whether fMRI can be used to support the diagnosis of chronic fatigue in future studies.
Depression and Depressive Symptoms in Pediatric Traumatic Brain Injury: A Scoping Review
Authors: Laliberté Durish Christianne , Pereverseff Rosemary S. , Yeates Keith O. 
Published: September 2017

Objective:
This scoping review aimed to summarize the existing knowledge base regarding depression and depressive symptoms in pediatric traumatic brain injury (TBI) and to identify gaps in the literature in an effort to guide future research.

Methods:
MEDLINE Ovid and PsycINFO Ovid databases were each searched by the authors using search terms intended to identify any original research study that examined depressive symptoms in children (ie, aged 0-18 years) with TBI.

Results:
A total of 14 published studies were included in the review. The studies included examined the prevalence of depression, risk factors associated with depression, and depression as a predictor of other TBI-related outcomes.

Conclusion:
Existing research suggests that depressive symptoms are more common in a TBI population than in a healthy or orthopedically injured population. Injury-related factors such as lesions in the brain and the presence of pain, as well as noninjury factors such as older age at injury and low socioeconomic status, may be predictive of depressive symptoms. Depression is likely a secondary outcome of pediatric TBI rather than a direct result of the injury itself. Overall, a relative dearth of research exists on this topic; thus, the review concludes by proposing future research directions.
Personality Traits in Panic Disorder Patients With and Without Comorbidities
Authors: Zugliani Morena M. , Martin-Santos Rocio , Nardi Antonio Egidio , Freire Rafael Christophe 
Published: September 2017

Abstract
Panic disorder (PD) is often correlated with high neuroticism and low extraversion. This study aims to ascertain whether PD patients differ from healthy controls in regard to personality traits and determine if these traits are correlated with comorbid disorders, anxiety, and depression symptoms. Personality traits of 69 PD patients and 42 controls were compared using the Maudsley Personality Inventory. In PD patients, comorbidities, anxiety, and depression symptoms were also evaluated. PD patients showed higher neuroticism and lower extraversion compared with healthy controls. Patients without comorbidities presented similar results to controls, whereas those with comorbidities presented higher neuroticism and lower extraversion scores. PD per se may be unrelated to deviant personality traits, although comorbidities with major depressive disorder and agoraphobia are probably associated with high neuroticism and low extraversion. These traits show a strong correlation with the accumulation and severity of these disorders.
High Levels of Morbidity and Mortality Among Pediatric Hematopoietic Cell Transplant Recipients With Severe Sepsis: Insights From the Sepsis PRevalence, OUtcomes, and Therapies International Point Prevalence Study*
Authors: Lindell Robert B. , Gertz Shira J. , Rowan Courtney M. , McArthur Jennifer , Beske Florian , Plunkett Adrian , Weiss Scott L. , Thomas Neal J. , Nadkarni Vinay M. , Fitzgerald Julie C. 
Published: September 2017

Objectives:
Pediatric severe sepsis is a major cause of morbidity and mortality worldwide, and hematopoietic cell transplant patients represent a high-risk population. We assessed the epidemiology of severe sepsis in hematopoietic cell transplant patients, describing patient outcomes compared with children with no history of hematopoietic cell transplant.

Design:
Secondary analysis of the Sepsis PRevalence, OUtcomes, and Therapies point prevalence study, comparing demographics, sepsis etiology, illness severity, organ dysfunction, and sepsis-related treatments in patients with and without hematopoietic cell transplant. The primary outcome was hospital mortality. Multivariable logistic regression models were used to determine adjusted differences in mortality.

Setting:
International; 128 PICUs in 26 countries.

Patients:
Pediatric patients with severe sepsis prospectively identified over a 1-year period.

Interventions:
None.

Measurements and Main Results:
In patients with severe sepsis, 37/567 (6.5%) had a history of hematopoietic cell transplant. Compared with patients without hematopoietic cell transplant, hematopoietic cell transplant patients had significantly higher hospital mortality (68% vs 23%; p < 0.001). Hematopoietic cell transplant patients were more likely to have hospital acquired sepsis and had more preexisting renal and hepatic dysfunction than non–hematopoietic cell transplant patients with severe sepsis. History of hematopoietic cell transplant, renal replacement therapy, admission from inpatient floor, and number of organ dysfunctions at severe sepsis recognition were independently associated with hospital mortality in multivariable analysis; hematopoietic cell transplant conferred the highest odds of mortality (odds ratio, 4.00; 95% CI, 1.78–8.98). In secondary analysis of hematopoietic cell transplant patients compared with other immunocompromised patients with severe sepsis, history of hematopoietic cell transplant remained independently associated with hospital mortality (odds ratio, 3.03; 95% CI, 1.11–8.27).

Conclusions:
In an international study of pediatric severe sepsis, history of hematopoietic cell transplant is associated with a four-fold increased odds of hospital mortality after adjustment for potential measured confounders. Hematopoietic cell transplant patients more often originated from within the hospital compared to children with severe sepsis without hematopoietic cell transplant, possibly providing an earlier opportunity for sepsis recognition and intervention in this high-risk population.
Do All Clavicle Fractures in Children Need To Be Managed by Orthopedic Surgeons?
Authors: Adamich John , Howard Andrew , Camp Mark 
Published: September 2017

Objectives
Although many uncomplicated pediatric fractures do not require routine long-term follow-up with an orthopedic surgeon, practitioners with limited experience dealing with pediatric fractures will often defer to a strategy of frequent clinical and radiographic follow-up. Development of an evidence-based clinical care pathway can help unnecessary radiation exposure to this patient population and reduce costs to patient families and the health care system.

Methods
A retrospective analysis including patients who presented to the Hospital for Sick Children (SickKids) for management of clavicle fractures was performed.

Results
Three hundred forty patients (227 males, 113 females) with an average age of 8.1 years (range, 0.1–17.8) were included in the study. The mean number of clinic visits including initial consultation in the emergency department was 2.1 (1.3). The mean number of radiology department appointments was 1.8 (1.3), where patients received a mean number of 4.2 (3.0) radiographs. Complications were minimal: 2 refractures in our series and no known cases of nonunion. All patients achieved clinical and radiographic union and returned to sport after fracture healing.

Conclusions
Our series suggests that the decision to treat operatively is made at the initial assessment. If no surgical indications were present at the initial assessment by the primary care physician, then routine clinical or radiographic follow-up is unnecessary. Our pediatric clavicle fracture pathway will reduce patient radiation exposure and reduce costs incurred by the health care system and patients' families without jeopardizing patient outcomes.
DNA Methylation–Targeted Drugs
Authors: Da Costa Elodie M. , McInnes Gabrielle , Beaudry Annie , Raynal Noël J.-M. 
Published: September 2017

Abstract
Targeting DNA hypermethylation, using nucleoside analogs, is an efficient approach to reprogram cancer cell epigenome leading to reduced proliferation, increased differentiation, recognition by the immune system, and ultimately cancer cell death. DNA methyltransferase inhibitors have been approved for the treatment of myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myelogenous leukemia. To improve clinical efficacy and overcome mechanisms of drug resistance, a second generation of DNA methyltransferase inhibitors has been designed and is currently in clinical trials. Although efficient in monotherapy against hematologic malignancies, the potential of DNA methyltransferase inhibitors to synergize with small molecules targeting chromatin or immunotherapy will provide additional opportunities for their future clinical application against leukemia and solid tumors.
Hidden Costs of Hospitalization After Firearm Injury
Authors: Rattan Rishi , Parreco Joshua , Namias Nicholas , Pust Gerd D. , Yeh D. Dante , Zakrison Tanya L. 
Published: September 2017

Objective:
To compare the risk factors and costs associated with readmission after firearm injury nationally, including different hospitals.

Background:
No national studies capture readmission to different hospitals after firearm injury.

Methods:
The 2013 to 2014 Nationwide Readmissions Database was queried for patients admitted after firearm injury. Logistic regression identified risk factors for 30-day same and different hospital readmission. Cost was calculated. Survey weights were used for national estimates.

Results:
There were 45,462 patients admitted for firearm injury during the study period. The readmission rate was 7.6%, and among those, 16.8% were readmitted to a different hospital. Admission cost was $1.45 billion and 1-year readmission cost was $131 million. Sixty-four per cent of those injured by firearms were publicly insured or uninsured. Readmission predictors included: length of stay >7 days [odds ratio (OR) 1.43, P < 0.01], Injury Severity Score >15 (OR 1.41, P < 0.01), and requiring an operation (OR 1.40, P < 0.01). Private insurance was a predictor against readmission (OR 0.81, P < 0.01). Predictors of readmission to a different hospital were unique and included: initial admission to a for-profit hospital (OR 1.52, P < 0.01) and median household income ≥$64,000 (OR 1.48, P < 0.01).

Conclusions:
A significant proportion of the national burden of firearm readmissions is missed by not tracking different hospital readmission and its unique set of risk factors. Firearm injury-related hospitalization costs $791 million yearly, with the largest fraction paid by the public. This has implications for policy, benchmarking, quality, and resource allocation.
Mitotic systemic genomic instability in yeast
Authors: Sampaio Nadia M. V. , Rodrigues-Prause Aline , Ajith V. P. , Gurol Theodore M. , Chapman Mary J. , Malc Ewa P. , Chakraborty Parijat , Duarte Fabiana M. , Aguirre Guadalupe M. , Tizei Pedro A. , Pereira Gonçalo A. G. , Mieczkowski Piotr A. , Nishant Koodali T. , Argueso Juan Lucas 
Published: September 2017

ABSTRACTConventional models of genome evolution generally include the assumption that mutations accumulate gradually and independently over time. We characterized the occurrence of sudden spikes in the accumulation of genome-wide loss-of-heterozygosity (LOH) inSaccharomyces cerevisiae, suggesting the existence of a mitotic systemic genomic instability process (mitSGI). We characterized the emergence of a rough colony morphology phenotype resulting from an LOH event spanning a specific locus (ACE2/ace2-A7). Surprisingly, half of the clones analyzed also carried unselected secondary LOH tracts elsewhere in their genomes. The number of secondary LOH tracts detected was 20-fold higher than expected assuming independence between mutational events. Secondary LOH tracts were not detected in control clones without a primary selected LOH event. We then measured the rates of single and double LOH at different chromosome pairs and found that coincident LOH accumulated at rates 30-100 fold higher than expected if the two underlying single LOH events occurred independently. These results were consistent between two different strain backgrounds, and in mutant strains incapable of entering meiosis. Our results indicate that a subset of mitotic cells within a population experience systemic genomic instability episodes, resulting in multiple chromosomal rearrangements over one or few generations. They are reminiscent of early reports from the classic yeast genetics literature, as well as recent studies in humans, both in the cancer and genomic disorder contexts, all of which challenge the idea of gradual accumulation of structural genomic variation. Our experimental approach provides a model to further dissect the fundamental mechanisms responsible for mitSGI.SIGNIFICANCE STATEMENTPoint mutations and alterations in chromosome structure are generally thought to accumulate gradually and independently over many generations. Here, we combined complementary genetic approaches in budding yeast to track the appearance of chromosomal changes resulting in loss-of-heterozygosity (LOH). Contrary to expectations, our results provided evidence for the occurrence of non-independent accumulation of multiple LOH events over one or a few cell generations. These results are analogous to recent reports of bursts of chromosomal instability in humans. Our experimental approach provides a framework to further dissect the fundamental mechanisms underlying systemic chromosomal instability processes, including in the human cancer and genomic disorder contexts.