bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health‐Related Quality of Life in an Inception Cohort of Children With Juvenile Idiopathic Arthritis: A Longitudinal Analysis
Authors: Oen Kiem , Guzman Jaime , Dufault Brenden , Tucker Lori B. , Shiff Natalie J. , Duffy Karen Watanabe , Lee Jennifer J. Y. , Feldman Brian M. , Berard Roberta A. , Dancey Paul , Huber Adam M. , Scuccimarri Rosie , Cabral David A. , Morishita Kimberly A. , Ramsey Suzanne E. , Rosenberg Alan M. , Boire Gilles , Benseler Susanne M. , Lang Bianca , Houghton Kristin , Miettunen Paivi M. , Chédeville Gaëlle , Levy Deborah M. , Bruns Alessandra , Schmeling Heinrike , Haddad Elie , Yeung Rae S. M. , Duffy Ciarán M. ,   the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh‐Out) investigators
Published: March 2017

ObjectiveTo describe changes in health‐related quality of life (HRQoL) over time in children with juvenile idiopathic arthritis (JIA), relative to other outcomes, and to identify predictors of unfavorable HRQoL trajectories.MethodsChildren with JIA in the Research in Arthritis in Canadian Children emphasizing Outcomes (ReACCh‐Out) cohort were included. The Juvenile Arthritis Quality of Life Questionnaire (JAQQ, a standardized instrument), health‐related Quality of My Life (HRQoML, an instrument based on personal valuations), and JIA core variables were completed serially. Analyses included median values, Kaplan‐Meier survival curves, and latent trajectory analysis.ResultsA total of 1,249 patients enrolled at a median of 0.5 months after diagnosis were followed for a median of 34.2 months. The degree of initial HRQoL impairment and probabilities of reaching the best possible HRQoL scores varied across JIA categories (best for oligoarthritis, worst for rheumatoid factor–positive polyarthritis). Median times to attain best possible HRQoL scores (JAQQ 59.3 months, HRQoML 34.5 months), lagged behind those for disease activity, pain, and disability measures. Most patients followed trajectories with minimal or mild impairment; however, 7.6% and 13.8% of patients, respectively, followed JAQQ and HRQoML trajectories with persistent major impairment in HRQoL. JIA category, aboriginal ethnicity, and baseline disease activity measures distinguished between membership in trajectories with major and minimal impairments.ConclusionImprovement in HRQoL is slower than for disease activity, pain, and disability. Improvement of a measure based on respondents’ preferences (HRQoML) is more rapid than that of a standardized measure (JAQQ). Higher disease activity at diagnosis heralds an unfavorable HRQoL trajectory.
Increased Insulin Resistance and Glucagon Levels in Mild/Inactive Systemic Lupus Erythematosus Patients Despite Normal Glucose Tolerance
Authors: Miyake Cíntia N. H. , Gualano Bruno , Dantas Wagner S. , Pereira Renato T. , Neves William , Zambelli Vanessa O. , Shinjo Samuel K. , Pereira Rosa M. , Silva Elizabeth R. , Sá‐Pinto Ana Lúcia , Borba Eduardo , Roschel Hamilton , Bonfá Eloisa , Benatti Fabiana B. 
Published: March 2017

ObjectiveTo assess insulin sensitivity in patients with systemic lupus erythematosus (SLE) in response to a meal tolerance test (MTT).MethodsIn this cross‐sectional study, 33 adult females with mild/inactive SLE (SLE group) and 16 age‐ and body mass index–matched female healthy controls (CTRL group) underwent an MTT and were assessed for insulin sensitivity and beta cell function. Skeletal muscle protein expressions of total and membrane insulin‐dependent glucose transporter 4 (GLUT‐4) were also evaluated (SLE group: n = 10, CTRL group: n = 5); muscle biopsies were performed after MTT. Further measurements included inflammatory cytokines, adipocytokines, physical activity level, body composition, and food intake.ResultsSLE and CTRL groups showed similar fasting glucose, glucose response, and skeletal muscle GLUT‐4 translocation after MTT. However, the SLE group demonstrated higher fasting insulin levels (P = 0.01; effect size [ES] 1.2), homeostatic model assessment insulin resistance (IR) (P = 0.03; ES 1.1), insulin‐to‐glucose ratio response to MTT (P = 0.02; ES 1.2), fasting glucagon levels (P = 0.002; ES 2.7), glucagon response to MTT (P = 0.0001; ES 2.6), and a tendency toward lower Matsuda index of whole‐body insulin sensitivity (P = 0.06; ES −0.5) when compared with the CTRL group. Fasting proinsulin‐to‐insulin ratio and proinsulin‐to‐insulin ratio response to MTT were similar between groups (P > 0.05), while the SLE group showed a higher insulinogenic index when compared with the CTRL group (P = 0.02; ES = 0.9).ConclusionWe have identified that SLE patients had a bi‐hormone metabolic abnormality characterized by increased IR and hyperglucagonemia despite normal glucose tolerance and preserved beta cell function and skeletal muscle GLUT‐4 translocation. Strategies capable of ameliorating insulin sensitivity to reduce the risk of type 2 diabetes mellitus and cardiovascular disease in SLE may require more than targeting IR alone.
Diagnostic Performance of Clinical Examination Measures and Pain Presentation to Identify Patellofemoral Joint Osteoarthritis
Authors: Stefanik J. J. , Duncan R. , Felson D. T. , Peat G. 
Published: March 2017

ObjectiveTo assess the diagnostic performance of a comprehensive set of tests and measures to discriminate patellofemoral (PF) from tibiofemoral (TF) osteoarthritis (OA).MethodsThe Clinical Assessment of the Knee Study is a study of knee pain in the general population. The presence of PF crepitus and pain with PF compression were assessed. Anterior knee pain was determined using a knee pain map. Pain with climbing/descending stairs and walking on level ground were assessed with the Western Ontario and McMaster Universities Osteoarthritis Index. Radiographs were used to define the compartment(s) of the knee affected by OA (no OA, isolated/predominant PF joint OA, and isolated/predominant TF joint OA). In knees with mixed OA, knees with more severe PF joint OA were included in the isolated/predominant PF group (the same was done for TF joint OA). We determined the sensitivity, specificity, positive predictive value (PPV), negative predictive value, and positive likelihood ratio (LR+) for each test and measure individually, and the combination of these measures, in distinguishing knees with PF joint OA from knees with TF joint OA or no OA.ResultsThere were 745 knees included in the study. No measure had high sensitivity and specificity. Pain with climbing/descending stairs had the greatest sensitivity (90%) but poor specificity (15%). The combination of definite crepitus with no pain on walking had the greatest specificity (96%), PPV (53%), and LR+ (1.8), but poor sensitivity (7%).ConclusionTypical clinical examination findings and knee pain patterns commonly thought to represent underlying PF joint pathology do not discriminate knees with PF joint OA from knees without OA or TF joint OA.
Vinylogous Nucleophilic Substitution of the Hydroxy Group in Diarylmethanols with 3‐Propenyl‐2‐silyloxyindoles: Towards the Synthesis of α‐Alkylidene‐δ‐diaryl‐2‐oxindoles
Authors: Jadhav Amol P. , Ali Amjad , Singh Ravi P. 
Published: March 2017

AbstractWe report herein a highly stereoselective method for the indium triflate‐catalyzed vinylogous substitution of the hydroxy group of diarylmethyl alcohols with 3‐alkenyl‐2‐silyloxyindoles, which affords broadly substituted α‐alkylidene‐δ‐diaryl‐2‐oxindole products with high efficiency and complete γ‐site and Z‐selectivity. The reaction displays very wide substrate scopes for both the reactants, benzhydryl alcohols and 3‐alkenyl‐2‐silyloxyindoles. The utility of the substituted adducts is shown by their conversion to other useful derivatives.magnified image
One‐Pot Sequential N‐Heterocyclic Carbene/Rhodium(III) Catalysis: Synthesis of Fused Polycyclic Isocoumarins
Authors: Youn So Won , Yoo Huen Ji 
Published: March 2017

AbstractA one‐pot sequential N‐heterocyclic carbene–rhodium (NHC‐Rh) catalysis is described, demonstrating the compatibility of NHC and Rh catalysts. N‐Heterocyclic carbene‐catalyzed aerobic oxidation of benzaldehydes and subsequent rhodium(III)‐catalyzed oxidative coupling/annulation with multiple bonds enabled the formation of two C–O bonds and one C–C bond in a single pot. This operationally easy, one‐pot protocol under air provides access to a diverse array of valuable fused polycyclic isocoumarins.magnified image
Developmental changes in feeding behaviors of infant chimpanzees at Mahale, Tanzania: Implications for nutritional independence long before cessation of nipple contact
Authors: Matsumoto Takuya 
Published: March 2017

AbstractObjectivesWeaning of chimpanzees is considered to occur at 4–5‐years‐old with complete cessation of nipple contact and timing of reconception calculated by inter‐birth interval minus gestation length. This is also the basis of “early weaning” in humans (i.e., approximately 2.5‐years‐old). However, recent studies of the survival of orphans and the first molar (M1) eruption in wild chimpanzees have predicted that infants move toward nutritional independence at 3‐years‐old. Therefore, this study aimed to investigate ontogeny of feeding behavior at around 3‐years‐old in wild infant chimpanzees.Materials and methodsI studied 19 infants aged 1–60 months in the M group in Mahale Mountains National Park, Tanzania. The total observation time was 518 h, 25 min.ResultsAt around 3‐years‐old, infant chimpanzees spent more total feeding time, and time feeding on leaves, and food physically difficult to process without food transfer from other individuals. These results suggest that infant chimpanzees significantly reduced their dependence on milk for nutrition at around 3‐years‐old, that is, before cessation of nipple contact.DiscussionThis study suggests that M1 eruption in wild Eastern Chimpanzees is an index of the period when infants move toward nutritional independence with a key dietary transition. This is the first study to provide behavioral evidence of the large temporal gap between nutritional independence of infants and reconception of mothers in great apes, and clarify the unique feature of human life history whereby mothers can reconceive before an infant reaches nutritional independence.
Pathomechanisms of anti–cytosolic 5′‐nucleotidase 1A autoantibodies in sporadic inclusion body myositis
Authors: Tawara Nozomu , Yamashita Satoshi , Zhang Xiao , Korogi Mai , Zhang Ziwei , Doki Tsukasa , Matsuo Yoshimasa , Nakane Shunya , Maeda Yasushi , Sugie Kazuma , Suzuki Naoki , Aoki Masashi , Ando Yukio 
Published: March 2017

ObjectiveSporadic inclusion body myositis (sIBM), an intractable progressive muscle disease, frequently occurs in older persons. sIBM pathogenesis may involve protein degradation dysfunction and immune abnormalities. Autoantibodies recognizing cytosolic 5′‐nucleotidase 1A (cN1A) were found in plasma and serum from sIBM patients. However, whether anti‐cN1A autoantibodies play a pathogenic role in sIBM is controversial. This study investigated the pathogenic properties of anti‐cN1A autoantibodies in sIBM pathogenesis.MethodsWe developed a cell‐based assay to detect anti‐cN1A autoantibodies, which we found in serum from patients with neuromuscular diseases including sIBM. We also investigated the clinicopathological differences between sIBM patients with and without the autoantibodies. We used passive in vitro and in vivo immunization models to evaluate the pathogenic role of the autoantibodies.ResultsOf 67 patients with sIBM, 24 (35.8%) possessed anti‐cN1A autoantibodies as determined via our cell‐based assay. In the anti‐cN1A–positive group, the percentage of patients with hepatitis C virus antibodies was significantly lower and the mean area of type 2 myofibers was significantly smaller compared with the autoantibody‐negative group. In the in vitro passive immunization model, p62/SQSTM1 significantly increased in anti‐cN1A–positive sIBM immunoglobulin G (IgG)‐supplemented cells. In the in vivo passive immunization model, anti‐cN1A–positive sIBM IgG‐injected mice demonstrated p62/SQSTM1‐positive sarcoplasmic aggregates in myofibers, associated with macrophage infiltration.InterpretationOur cell‐based assay is useful for anti‐cN1A autoantibodies detection. Patients with anti‐cN1A autoantibodies demonstrated unique clinicopathological features. In vitro and in vivo passive immunization model results suggest that anti‐cN1A autoantibodies may affect protein degradation in myofibers. Ann Neurol 2017;81:512–525
Catalytic Direct‐type 1,4‐Addition Reactions of Alkylazaarenes
Authors: Suzuki Hirotsugu , Igarashi Ryo , Yamashita Yasuhiro , Kobayashi Shū 
Published: March 2017

Abstract1,4‐addition reactions of alkylazaarenes catalyzed by strong Brønsted bases have been developed for the first time. The desired reactions with α,β‐unsaturated amides proceeded under mild reaction conditions to give the 1,4‐adducts in high yields. Both ortho‐ and para‐substituted azaarenes afforded the desired adducts in high yields. Regioselective reactions of di‐ or trimethylpyridine were found to be possible depending on the acidity of the α‐hydrogen atoms. Furthermore, a candidate of allosteric protein kinase modulators was synthesized in two steps. An asymmetric variant of this reaction was also found to be feasible.
Composition‐Dependent Hot Carrier Relaxation Dynamics in Cesium Lead Halide (CsPbX3, X=Br and I) Perovskite Nanocrystals
Authors: Chung Heejae , Jung Seok Il , Kim Hyo Jin , Cha Wonhee , Sim Eunji , Kim Dongho , Koh Weon‐Kyu , Kim Jiwon 
Published: March 2017

AbstractCesium‐based perovskite nanocrystals (NCs) have outstanding photophysical properties improving the performances of lighting devices. Fundamental studies on excitonic properties and hot‐carrier dynamics in perovskite NCs further suggest that these materials show higher efficiencies compared to the bulk form of perovskites. However, the relaxation rates and pathways of hot‐carriers are still being elucidated. By using ultrafast transient spectroscopy and calculating electronic band structures, we investigated the dependence of halide in Cs‐based perovskite (CsPbX3 with X=Br, I, or their mixtures) NCs on the hot‐carrier relaxation processes. All samples exhibit ultrafast (<0.6 ps) hot‐carrier relaxation dynamics with following order: CsPbBr3 (310 fs)>CsPbBr1.5I1.5 (380 fs)>CsPbI3 NC (580 fs). These result accounts for a reduced light emission efficiency of CsPbI3 NC compared to CsPbBr3 NC.
Grünlicht‐induzierte Rezeptorinaktivierung durch Cobalamin‐bindende Domänen
Authors: Kainrath Stephanie , Stadler Manuela , Reichhart Eva , Distel Martin , Janovjak Harald 
Published: March 2017

AbstractOptogenetik und Photopharmakologie ermöglichen präzise räumliche und zeitliche Kontrolle von Proteinwechselwirkung und ‐funktion in Zellen und Tieren. Optogenetische Methoden, die auf grünes Licht ansprechen und zum Trennen von Proteinkomplexen geeignet sind, sind nicht weitläufig verfügbar, würden jedoch mehrfarbige Experimente zur Beantwortung von biologischen Fragestellungen ermöglichen. Hier demonstrieren wir die Verwendung von Cobalamin(Vitamin B12)‐bindenden Domänen von bakteriellen CarH‐Transkriptionsfaktoren zur Grünlicht‐induzierten Dissoziation von Rezeptoren. Fusioniert mit dem Fibroblasten‐Wachstumsfaktor‐Rezeptor 1 führten diese im Dunkeln in kultivierten Zellen zu Signalaktivität durch Oligomerisierung, welche durch Beleuchten umgehend aufgehoben wurde. In Zebrafischembryonen, die einen derartigen Rezeptor exprimieren, ermöglichte grünes Licht die Kontrolle über abnormale Signalaktivität während der Embryonalentwicklung.
Polarisation auf der Mesoskala durch geometrische Frustration in kolumnaren supramolekularen Kristallen
Authors: Zehe Christoph S. , Hill Joshua A. , Funnell Nicholas P. , Kreger Klaus , van der Zwan Kasper P. , Goodwin Andrew L. , Schmidt Hans‐Werner , Senker Jürgen 
Published: March 2017

AbstractKolumnare supramolekulare Phasen, die eine Polarisation entlang der Kolumnenachse aufweisen, haben das Potential zur Entwicklung von Datenspeichern mit ultrahoher Dichte, da jede einzelne Kolumne als Speicherelement fungieren kann. Wir zeigen anhand von Untersuchungen der Struktur und Unordnung von vier kolumnaren 1,3,5‐Benzoltrisamiden mittels totaler Röntgenstreuung und DFT‐Rechnungen, dass die Kolumnenorientierung und damit das kolumnare Dipolmoment empfindlich auf geometrische Frustration ist, sofern die Kolumnen in hexagonalen Stabpackungen aggregieren. Die Frustration unterdrückt die konventionelle antiferroelektrische Ordnung und erhöht die Sensitivität für kollektive interkolumnare Packungseffekte. Dieser Befund erlaubt es, Domänen auf der Mesoskala zu erzeugen, die eine spontane Polarisation aufweisen. Unsere Ergebnisse zeigen auf, wie das komplexe Zusammenspiel von sterischen und elektrostatischen Wechselwirkungen durch ein einfaches Design der molekularen Synthone beeinflusst wird, um spontane Polarisation zu erzeugen und die Größe der mesoskopischen Domänen einzustellen.
Merging Distal Alkynyl Migration and Photoredox Catalysis for Radical Trifluoromethylative Alkynylation of Unactivated Olefins
Authors: Xu Yan , Wu Zhen , Jiang Jingxing , Ke Zhuofeng , Zhu Chen 
Published: March 2017

AbstractDisclosed herein is a novel, redox‐neutral protocol for the visible‐light‐induced radical alkynylation of unactivated olefins. The intramolecular migration of an alkynyl group, by cleaving an inert C−C σ bond, is realized for the first time. A wide range of synthetically useful trifluoroethylated linear alkynes are readily obtained under mild reaction conditions.
Successive Charge Transitions of Unusually High‐Valence Fe3.5+: Charge Disproportionation and Intermetallic Charge Transfer
Authors: Hosaka Yoshiteru , Denis Romero Fabio , Ichikawa Noriya , Saito Takashi , Shimakawa Yuichi 
Published: March 2017

AbstractA perovskite‐structure oxide containing unusually high‐valence Fe3.5+ was obtained by high‐pressure synthesis. Instability of the Fe3.5+ in Ca0.5Bi0.5FeO3 is relieved first by charge disproportionation at 250 K and then by intermetallic charge transfer between A‐site Bi and B‐site Fe at 200 K. These previously unobserved successive charge transitions are due to competing intermetallic and disproportionation charge instabilities. Both transitions change magnetic and structural properties significantly, indicating strong coupling of charge, spin, and lattice in the present system.
Bis‐Gadolinium Complexes for Solid Effect and Cross Effect Dynamic Nuclear Polarization
Authors: Kaushik Monu , Qi Mian , Godt Adelheid , Corzilius Björn 
Published: March 2017

AbstractHigh‐spin complexes act as polarizing agents (PAs) for dynamic nuclear polarization (DNP) in solid‐state NMR spectroscopy and feature promising aspects towards biomolecular DNP. We present a study on bis(Gd‐chelate)s which enable cross effect (CE) DNP owing to spatial confinement of two dipolar‐coupled electron spins. Their well‐defined Gd⋅⋅⋅Gd distances in the range of 1.2–3.4 nm allowed us to elucidate the Gd⋅⋅⋅Gd distance dependence of the DNP mechanism and NMR signal enhancement. We found that Gd⋅⋅⋅Gd distances above 2.1 nm result in solid effect DNP while distances between 1.2 and 2.1 nm enable CE for 1H, 13C, and 15N nuclear spins. We compare 263 GHz electron paramagnetic resonance (EPR) spectra with the obtained DNP field profiles and discuss possible CE matching conditions within the high‐spin system and the influence of dipolar broadening of the EPR signal. Our findings foster the understanding of the CE mechanism and the design of high‐spin PAs for specific applications of DNP.
Twisted Aromatic Frameworks: Readily Exfoliable and Solution‐Processable Two‐Dimensional Conjugated Microporous Polymers
Authors: Marco A. Belen , Cortizo‐Lacalle Diego , Perez‐Miqueo Iñigo , Valenti Giovanni , Boni Alessandro , Plas Jan , Strutyński Karol , De Feyter Steven , Paolucci Francesco , Montes Mario , Khlobystov Andrei N. , Melle‐Franco Manuel , Mateo‐Alonso Aurelio 
Published: March 2017

AbstractTwisted two‐dimensional aromatic frameworks have been prepared by overcrowding the nodes with bulky and rigid substituents. The highly distorted aromatic framework with alternating out‐of‐plane substituents results in diminished interlayer interactions that favor the exfoliation and dispersion of individual layers in organic media.
Tandem Coupling of Azide with Isonitrile and Boronic Acid: Facile Access to Functionalized Amidines
Authors: Zhang Zhen , Huang Baoliang , Qiao Guanyu , Zhu Liu , Xiao Fan , Chen Feng , Fu Bin , Zhang Zhenhua 
Published: March 2017

AbstractAmidine is a notable nitrogen‐containing structural motif found in bioactive natural products and pharmaceuticals. Herein, a novel rhodium(I)‐catalyzed tandem reaction of readily accessible azides with isonitriles and boronic acids via a carbodiimide intermediate is achieved. This protocol offers an alternative approach toward N‐sulfonyl‐, N‐acyl‐, and N‐ phosphoryl‐functionalized, as well as general N‐aryl and N‐alkyl amidines with broad substrate scope. In addition, functionalized guanidines can also been synthesized when amines are used instead. The accomplishment of estrone‐derived amidine and glibenclamide bioisosteres further reveals the practical utility of this strategy.
Brønsted Acid Catalysis in Visible‐Light‐Induced [2+2] Photocycloaddition Reactions of Enone Dithianes
Authors: Brenninger Christoph , Pöthig Alexander , Bach Thorsten 
Published: March 2017

Abstract1,3‐Dithiane‐protected enones (enone dithianes) were found to undergo an intramolecular [2+2] photocycloaddition under visible‐light irradiation (λ=405 nm) in the presence of a Brønsted acid (7.5–10 mol %). Key to the success of the reaction is presumably the formation of colored thionium ions, which are intermediates of the catalytic cycle. Cyclobutanes were thus obtained in very good yields (78–90 %). It is also shown that the dithiane moiety can be reductively or oxidatively removed without affecting the photochemically constructed ring skeleton.
Comparative study of PEO and PVA hydrogels for removal of methylene blue dye from wastewater
Authors: Teixeira Raquel S. P. , Correa Rodrigo J. , Bello Forero Josué S. , Silva Mariana G. S. , Oliveira Ronaldo C. S. , Souza Rodrigo S. 
Published: March 2017

ABSTRACTIn this study, poly(vinyl alcohol) (PVA) and poly(ethylene oxide) (PEO) hydrogels were synthesized and evaluated as adsorbent for dye removal from wastewater using methylene blue (MB) in aqueous solution as probe. PEO samples were photochemically prepared by varying irradiation time (1–16 h), while PVA samples were synthetized with different concentration of glutaraldehyde (GA) (0.03–0.48%). The obtained hydrogels were obtained through the analysis of a swelling test, scanning electron microscopy, and adsorption studies. PEO hydrogels adsorption capacity was dependent on the irradiation time, while the PVA hydrogel adsorption capacity reduces with GA concentration. Both hydrogels demonstrated a Langmuir isotherm adsorption model at the equilibrium and pseudo‐second order kinetic fits properly. pH studies showed that when pH reaches 12, the adsorbed MB amount is close to 8 and 2 times higher than pH = 2 both hydrogels. Photochemical preparation of hydrogels shows an easier way of tuning their properties in order to maximize dye removal. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45043.