bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exposure-Response–Based Multiattribute Clinical Utility Score Framework to Facilitate Optimal Dose Selection for Oncology Drugs
Authors: Cheng Yiming , Chu Shuyu , Pu Jie , Chen Min , Hong Kevin , Maciag Paulo , Chan Ivan , Zhu Li , Bello Akintunde , Li Yan 
Published: September 2024

PURPOSE

The advent of new therapeutic modalities highlighted deficiencies in the traditional maximum tolerated dose approach for oncology drug dose selection and prompted the Food and Drug Administration (FDA)'s
Project Optimus
initiative, which suggests that sponsors take a holistic approach, including efficacy, safety, and pharmacokinetic (PK) and pharmacodynamic data, in conjunction with integrated exposure-response (ER) analyses. However, this method comes with an inherent challenge of the collation of the multisource data. To address this issue, an ER-based clinical utility score (CUS) framework, combining benefit and risk into a single measurement, was developed.

METHODS
Model-predicted outcomes for each clinically relevant end point, informed by ER modeling, are converted to a CUS using a user-defined utility function. Thereafter, individual CUS is integrated into a single score with user-defined weighting for each end point. The user-defined weighting feature allows the user to incorporate expert knowledge/understanding into weighing the product's benefit versus risk profile.

RESULTS
To validate the framework, data were leveraged from over 50 oncology programs from 2019 to 2023 on the basis of FDA new drug application/biologics license application review packages and/or related literature studies. Five representative cases were selected for in-depth evaluation. Results showed that the optimal benefit-risk ratio (highest CUS) was consistently observed at PK exposures synonymous with recommended doses. A recurring theme across cases was a greater emphasis on safety over efficacy in oncology drug dose determination.

CONCLUSION

The ER-based CUS framework offers a strategic tool to navigate the complexities of dose selection in oncology programs. It serves as a pillar to the importance of integrative data analysis, aligning with the vision of
Project Optimus
, and demonstrates its potential in guiding dose optimization by balancing therapeutic benefits against risk.
Rewarding Frugality
Authors: Lee Anna Jungeun 
Published: September 2024

Abstract
This article considers frugality as an important political praxis in South Korea's Park Chung Hee period (1961–79), examining “frugality awards” that encouraged bureaucrats and citizens to practice “ascetic nationalism” in daily life contexts. The authoritarian state attempted to institutionalize frugality, as spending less and saving more became a visual indicator of one's dedication, sacrifice, and alignment with the state's collective vision of fast-paced economic growth. Seemingly mundane activities such as switching off lights and making fewer phone calls became a cultural prescription of the state, with award recommendations evaluating how a civil servant, his family, and their neighbors performed these activities. To become frugal, people strove to control their immediate environment, manage resources, and perform thrift. Administering frugality became a “fingertip” project of the authoritarian state. The state's collective claims on frugality existed in ambivalent relation to capitalist forces, however, as one of the incentives to perform frugality became collecting the reward money, compromising its goals from the inside out.
“Swoop and Grab Your Rights”
Authors: Nath Nivedita 
Published: September 2024

Abstract
This article centers community archives as sources of history as well as sites of theory to map interconnected social and ecological struggles in the Niti Valley of the central Himalayas from the late nineteenth to the late twentieth centuries. Tolchha and Marchha communities have integrated different ecological belts over centuries through lifeways of trade, pastoralism, and herb gathering. Colonial and postcolonial policies threatened to sever these lifeways through militarized borders, timber extraction, and the demarcation of the exclusive boundaries of the Nanda Devi Biosphere Reserve. Yet tribal communities have fought to maintain ancestral relations with land by infringing upon colonial restrictions and defying dichotomies of nature and culture through the postcolonial Chipko and Jhapto Cheeno movements. Juxtaposing official archives with community archives from Lata Village, this article argues that leaders of people's movements have sought to reclaim authority over Himalayan history and resituate rural struggles within the framework of Indigenous spatial knowledges.
Calcified maxillary fibroma in a patient on hemodialysis for seven years
Authors: Putranto Wachid , Pratama Yeremia Suryo , Krisandryka Krisandryka , Pangarso Eko Adi , Astuti Meira Dewi Kusuma , Prabowo Nurhasan Agung 
Published: September 2024

Background: The presentation of mineral bone disorder (MBD) in individuals with chronic kidney disease (CKD) may vary. Consequently, physicians should be capable of recognising this condition when there is a suspicion of its existence. This case report will describe a calcified maxilla tumour as a manifestation of CKD-MBD. Case description: Initially asymptomatic, a 32-year-old female presented with progressive swelling of the upper left jaw. She had a history of routine haemodialysis. Further laboratory, radiological, and histopathological workup revealed the mass was indeed calcified maxillary fibroma arising from the manifestation of CKD-MBD. Conclusion: This study underscores the significance of clinical comprehension of the broad-spectrum manifestations of CKD-MBD, including an initially asymptomatic mass. In addition, the screening of the patient’s biochemical was required to determine the necessity of early intervention and improve the patient’s outcome.
Quantum steering from phase measurements with limited resources
Authors: Bizzarri Gabriele , Gianani Ilaria , Manrique Mylenne , Berardi Vincenzo , Bruni Fabio , Capellini Giovanni , Barbieri Marco 
Published: September 2024

We extend a metrology-assisted protocol to certify steering, explicitly accounting for experimental imperfections, in a limited resource scenario.
Our results provide guidelines to apply such a metrological approach to the validation of quantum channels.
The impact of modified incision height and surgical procedure on trichiasis surgery outcomes: Results of the maximizing trichiasis surgery success (MTSS) randomized trial
Authors: Gower Emily W. , Sisay Alemayehu , Bayissasse Belay , Seyum Dawit , Weaver Jerusha , Munoz Beatriz , Keil Alexander P. , Bankoski Andrea , Sullivan Kristin M. , Kana Hashiya , Admassu Fisseha , Tadesse Demissie , Merbs Shannath L. 
Published: September 2024

Background
Poor surgical outcomes remain a problem in trachoma-endemic countries working to reach elimination thresholds. Methods to improve outcomes could positively impact programmatic success.

Methods
This parallel, three-armed clinical trial conducted in Ethiopia randomized individuals with previously unoperated trachomatous trichiasis (TT) to receive surgery utilizing one of three approaches: bilamellar tarsal rotation with a 3 mm incision height (BLTR-3), BLTR with 5 mm incision height (BLTR-5) and posterior lamellar tarsal rotation (PLTR). We followed participants for one year. The primary outcome was post-operative trichiasis (PTT). Secondary outcomes were eyelid contour abnormalities (ECA) and pyogenic granulomata.

Findings
We randomized and operated on 4,914 individuals with previously unoperated TT (6,940 eyes). Primary analyses include 6,815 eyes with follow-up. Overall, 1,149 (16.9%) eyes developed PTT. The risk difference for PTT was minimal comparing BLTR-3 and PLTR (adjusted risk difference [aRD] 1.8% (98.3%CI: -0.5–4.2%)), but significantly higher for BLTR-5 surgeries compared to BLTR-3 (aRD: 6.7% (3.9–9.4%)) and PLTR (aRD: 8.6% (5.9–11.3%)). BLTR-5 had the lowest ECA (6.1% versus 9.6% BLTR-3, 11.2% PLTR) and granuloma rates (5.2% versus 6.5% BLTR-3 and 7.5% PLTR). One eyelid operated with PLTR experienced an eyelid margin division; four BLTR-3 and eight BLTR-5 eyelids experienced excessive bleeding.

Interpretation
We do not recommend modifying the BLTR incision height of 3 mm. Overall, we did not find a significant difference in PTT between BLTR-3 and PLTR in terms of PTT or ECA.

Trial registration
Registration number: NCT03100747; ClinicalTrials.gov
Full study protocol available at (https://doi.org/10.15139/S3/QHZXWD)
A novel antigen biomarker for detection of high-level of Loa loa microfilaremia
Authors: Greene Sarah E. , Huang Yuefang , Fischer Kerstin , Rosa Bruce A. , Martin John , Mitreva Makedonka , Yates Devyn , Wanji Samuel , Kamgno Joseph , Budge Philip J. , Weil Gary J. , Fischer Peter U. 
Published: September 2024

Background
Loiasis is a disease caused by the nematode Loa loa. Serious adverse events sometimes occur in people with heavy L. loa microfilaremia after ivermectin treatment. In regions of Central Africa where loiasis is endemic, this significantly impedes global elimination programs for lymphatic filariasis and onchocerciasis that use mass distribution of ivermectin. Improved diagnostic tests to identify individuals at increased risk of serious adverse events could facilitate efforts to eliminate lymphatic filariasis and onchocerciasis in this region.

Methods and findings
We previously identified the L. loa protein Ll-Bhp-1 in loiasis patient sera. Here, we further characterize Ll-Bhp-1 and report development of an antigen capture ELISA to detect this antigen. This assay detected Ll-Bhp-1 in 74 of 116 (63.8%) loiasis patient sera. Ll-Bhp-1 levels were significantly correlated with L. loa microfilarial counts, and the sensitivity of the assay was highest for samples from people with high counts, (94% and 100% in people with ≥20,000 and ≥50,000 microfilaria per milliliter of blood, respectively). The antigen was not detected in 112 sera from people with other filarial infections, or in 34 control sera from the USA.

Conclusions
This Ll-Bhp-1 antigen assay is specific for loiasis, and highly sensitive for identifying people with high L. loa microfilarial counts who are at increased risk for serious adverse events after ivermectin treatment. L. loa antigen detection has the potential to facilitate loiasis mapping efforts and programs to eliminate lymphatic filariasis and onchocerciasis in Central Africa.
Changing seroprevalence of schistosomiasis japonica in China from 1982 to 2020: A systematic review and spatial analysis
Authors: Zhou Yu , Zheng Mao , Gong Yanfeng , Huang Junhui , Wang Jiamin , Xu Ning , Tong Yixin , Chen Yue , Jiang Qingwu , Cai Yu , Zhou Yibiao 
Published: September 2024

Background
Schistosomiasis is a global public health issue. In China, while the seroprevalence of Schistosomiasis japonica has currently reduced to a relatively low level, risk of infection still exists in certain areas. However, there has been a lack of comprehensive research on the long-term trends of national seroprevalence, changes across age groups, and characteristics in spatial distribution, which is crucial for effectively targeting interventions and achieving the goal of eliminating schistosomiasis by 2030. Our study aimed to address this gap by analyzing the long-term trends of Schistosomiasis japonica seroprevalence in China from 1982 to 2020 based on the data from diverse sources spanning a period of 39 years.

Methodology
Seroprevalence data were collected from literature databases and national schistosomiasis surveillance system. Meta-analysis was conducted to estimate the seroprevalence. Joinpoint model was used to identify changing trend and inflection point. Inverse distance weighted interpolation was used to determine the spatial distribution of seroprevalence.

Principal findings
The seroprevalence decreased from 34.8% in 1982 to 2.4% in 2020 in China. Before 2006, the seroprevalence was higher in the middle age group, and a pattern of increasing with age was observed afterwards. The areas with high seroprevalence existed in Dongting Lake, Poyang Lake, Jianghan Plain, the Anhui branch of the Yangtze River and some localized mountainous regions in Sichuan and Yunnan provinces.

Conclusions/Significance
There was a significant decline in the seroprevalence of Schistosomiasis japonica from 1982 to 2020 in China. Nevertheless, schistosomiasis has not been eradicated; thus, implementing precise and personalized monitoring measures is crucial for the elimination of schistosomiasis, especially in endemic areas and with a particular focus on the elderly.
Changes in mortality due to Chronic Liver Diseases (CLD) during the COVID-19 pandemic: Data from the United States’ National Vital Statistics System
Authors: Paik James M. , Shah Dipam , Eberly Katherine , Golabi Pegah , Henry Linda , Younossi Zobair M. 
Published: September 2024

Introduction
We assessed chronic liver disease (CLD)-related mortality in the U.S. using death data (2011–2021) obtained from National Vital Statistics System (NVSS). The average annual percentage change (AAPC) from the models selected by Joinpoint regression analysis over the pre-pandemic (2011–2019) and the 2019–2021 were reported because non-linear trend in death rates were observed over the 2011–2021. Liver-specific death was defined as an underlying cause of death and Chronic liver disease (CLD)-related death was defined as any cause of death. During the pre-pandemic, age-standardized HCC- and cirrhosis-specific death rates were annually increased by AAPC = +1.18% (95% confidence interval, 0.34% to 2.03%) and AAPC = +1.95% (1.56% to 2.35%). In contrast, during the 2019–2021, the AAPC in age-standardized cirrhosis-specific death rate (per 100,000) accelerated by up to AAPC +11.25% (15.23 in 2019 to 18.86 in 2021) whereas that in age-standardized HCC-specific death rate slowed to -0.39 (-1.32% to 0.54%) (3.86 in 2019 to 3.84 in 2021). Compared to HCC-specific deaths, cirrhosis-specific deaths were more likely to be non-Hispanic white (72.4% vs. 62.0%) and non-Hispanic American Indian and Alaska native (AIAN) (2.2% vs. 1.1%) and have NAFLD (45.3% vs. 12.5%) and ALD (27.6% vs. 22.0%). During the 2019–2021, the age-standardized HCV- and HBV-related death rate stabilized, whereas the age-standardized NAFLD- and ALD-related deaths rate increased to 20.16 in 2021 (AAPC = +12.13% [7.76% to 16.68%]) and to 14.95 in 2021 (AAPC = +18.30% [13.76% to 23.03%]), which were in contrast to much smaller incremental increases during the pre-pandemic (AAPC = +1.82% [1.29% to 2.35%] and AAPC = +4.54% [3.97% to 5.11%]), respectively). The most pronounced rise in the age-standardized NAFLD-related death rates during the pandemic was observed among AIAN (AAPC = +25.38%), followed by non-Hispanic White female (AAPC = +14.28%), whereas the age-standardized ALD-related death rates during the pandemic were highest among AIAN (AAPC = +40.65%), followed by non-Hispanic Black female (AAPC = +26.79%).

Conclusions
COVID-19 pandemic had a major negative impact on cirrhosis-specific and CLD-related mortality in the U.S. with significant racial and gender disparities.
Assessment of photodynamic therapy with annatto and led for the treatment of halitosis in mouth-breathing children: Randomized controlled clinical trial
Authors: Bruno Laura Hermida , Mandetta Amanda Rafaelly Honório , Sobral Ana Paula Taboada , Leal Gonçalves Marcela Leticia , Santos Elaine Marcilio , Fossati Ana Laura , Gallo Juliana Maria Altavista Sagretti , Motta Pamella de Barros , Deana Alessandro Melo , Horliana Anna Carolina Ratto Tempestini , Motta Lara Jansiski , Ferrari Raquel Agnelli Mesquita , Santos Fernandes Kristianne Porta , Kalil Bussadori Sandra 
Published: September 2024

Objective
To assess the effectiveness of antimicrobial photodynamic therapy (aPDT) employing an annatto-based (20%) dye combined with blue LED for the treatment of halitosis in mouth-breathing children.

Materials and methods
Fifty-two children six to twelve years of age with diagnoses of mouth breathing and halitosis (score of ≥ 3 on portable breath meter) Breath Alert™ (Tanita Corporation®-Japan), were randomly allocated to two groups (n = 26). Group 1: brushing, dental floss and aPDT applied to middle third of the dorsum of the tongue. Group 2: brushing, dental floss and tongue scraper. Breath meter results before, immediately after treatment as well as seven and 30 days after treatment were compared. The hypothesis of normality in the data was discarded by the Shapiro-Wilk test (p < 0.05) and for statistical analysis the Wilcoxon and Mann-Whitney tests were used.

Results
A significant difference was found between the pre-treatment reading and all other readings (p < 0.05) in both groups, suggesting the effectiveness of the proposed treatments. No significant difference was found between the post-treatment reading and two follow-up readings, suggesting the maintenance of the effect of treatment over time (p > 0.05). However, significant differences were found between groups for all post-treatment assessments (p < 0.0001 for all comparisons), indicating greater effectiveness with aPDT. No association was found between the initial reading and the presence of coated tongue.

Conclusion
Antimicrobial photodynamic therapy using annatto and blue LED proved to be a viable therapeutic option for the treatment of halitosis in mouth-breathing children.
Presenting decision-relevant numerical information to Dutch women aged 50–70 with varying levels of health literacy: Case example of adjuvant systemic therapy for breast cancer
Authors: van Strien-Knippenberg Inge S. , Timmermans Daniëlle R. M. , Engelhardt Ellen G. , Konings Inge R. H. M , Damman Olga C. 
Published: September 2024

Background
If communicated adequately, numerical decision-relevant information can support informed and shared decision making. Visual formats are recommended, but which format supports patients depending on their health literacy (HL) levels for specific decisions is unclear.

Study aim
The aim of this study is to investigate: 1) the effect of survival rates and side-effects presentation formats on comprehension and ‘feeling informed’; 2) differential effects among women with higher/lower HL, with adjuvant systemic breast cancer therapy as case example.

Methods
Two online experiments among women from the Dutch population without a history of breast cancer were conducted. Experiment 1 had a 3 (survival rate format: text block–bar graph–icon array) x 2 (HL: low–high) between-subjects design. Experiment 2 had a 5 (side-effects format: no probability information–probability information in numbers with or without a visualisation–probability information in numbers with or without a visualisation accompanied by a description of the side-effects) x 2 (HL: low–high) design. Primary outcomes were comprehension and feeling informed (Experiment 2 only). Formats were previously designed in co-creation with patients.

Results
In Experiment 1, presentation format did not affect gist or verbatim comprehension. Higher HL was associated with higher gist comprehension. Experiment 2 showed an interaction between presentation format and HL on ‘feeling informed’. When provided with visualised probability information without a description of the side-effects, women with lower HL felt better informed than women with higher HL.

Conclusion
Visual formats did not enhance comprehension of survival rate information beyond a well-designed text block format. However, none of the formats could overcome HL differences. When designing decision-relevant information, visualisations might not necessarily provide an advantage over structured numerical information for both patients with lower and higher HL. However, a deeper understanding of presenting side-effect information is warranted.
The Analysis of the Technological Developments for the Human Health Especially for the Effects of Changing Environment
Authors: Mándy Zoltán 
Published: September 2024

In my imaginations are about all the developments which can be connect with human health.In this study I show what are the main problems with all of the technological developmets all around the globe.There are so many publications which discuss the main problems and they tries to show the solutions, but these are the most difficult problems because the human do not want to leave the easier solutions about his life nowadays. It is enough to mention that the uses of bicycle instead of the cars especially ever since the European Union finished the all around development so bicycle ways in the area of and between the cities in Europen countries. It is important to know, that there are so many talented student in University of Miskolc, at Faculty of Healthcare, for example at Health-visitor and prevention professionals, who interested in in multi-and interdisciplinar borderlines of professionalism between science of health and law and technological science.We have to mention that this study is a begin of a new trend in this Faculty.
Touch and Temporality in Selected Manuscripts of the Roman de Troie and the Roman d’Eneas
Authors: Bridges Venetia 
Published: September 2024

Abstract
This article considers the intimate connections between proximity, temporality and metanarrative in selected thirteenth- and fourteenth-century multi-text manuscripts of Benoît de Sainte-Maure’s Roman de Troie (c. 1165) and the Roman d’Eneas (c. 1155), arguing that all display a desire for narratives of the past to construct collective meaning in the later medieval present. It uses the phrase romance historicity/ies to explore the compilatory metanarratives that these books construct, arguing that romance as a genre displays a multifaceted concept of history that combines linear chronology, thematic repetition and narratives of heroic individuals, which is demonstrated in varying degrees in these manuscripts. It highlights that although genre is indeed an important organising principle in such narratives, the relationship between romance and history is fluid even within this generic horizon of expectation.
Losing Ground: Measuring the Welfare Effects of Retail Food Price Inflation during the COVID-19 Pandemic on Mexican Household
Authors: Nava Noé J. , Wood Benjamin D. K. , Garduño-Rivera Rafael 
Published: September 2024

Abstract
As worldwide food prices rise, there is a growing interest in understanding the effect of these increases on households. Building on previous work, while applying recent methodological advances, we focus our attention on México during the COVID-19 pandemic. We document these price escalations for a basket of foods representative of Mexican households’ diets. The price increases are substantial across the basket, ranging from 20 percent in meat to 40 percent in tortilla. Using these estimates, we calculate the welfare effect from the recent food price escalation to cost households $17.07 billion annually, close to 1.5 percent of Mexico’s Gross Domestic Product in 2020. We estimate households would need to increase their food expenditure budgets by 28.66 percent, the compensating variation, to achieve pre-price increase utility levels.