bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pobeguinine: a monoterpene indole alkaloid and other bioactive constituents from the stem bark of Nauclea pobeguinii
Authors: Bankeu Jean J.K. , Madjouka Stéphanie , Feuya Guy R.T. , Fongang Yannick S.F. , Siddiqui Sadaf , Ali Iftikhar , Mehreen Lateef , Lenta Bruno N. , Yousuf Sammer , Noungoué Didérot T. , Ngouela Augustin S. , Ali Muhammad S. 
Published: January 2018

Abstract
Phytochemical investigation of dichloromethane neutral phase of stem bark of Nauclea pobeguinii led to the isolation of a new monoterpene indole alkaloid, pobeguinine 1 along with 14 known compounds including (−)-naucleofficine D (2a), (+)-naucleofficine D (2b), naucleidinal (3), quafrinoic acid (4), betulinic acid (5), ursolic acid (6), quinovic acid (7), quinovic acid 3-O-α-L-rhamnopyranoside (8a), quinovic acid 3-O-β-D-fucopyranoside (8b), β-sitosterol (9), β-sitosterol 3-O-β-D-glucopyranoside (10), benzoic acid (11), lacceroic acid (12) and n-heptacosane (13). The structure of compound 1 was unambiguously assigned on the basis of single-crystal X-ray diffraction technique. The Hirshfeld surface analysis was further carried out to quantitatively analyze the role of various types of hydrogen bonding in crystal stability. These structures were elucidated using spectroscopic methods. The isolates were evaluated for their radical scavenging properties as well as inhibitory activities against urease and tyrosinase enzymes with IC50 values ranging from 13.4 to 58.9, 46.0 to 86.7 and 39.4 to 87.1 μg/mL, respectively. Compound 6 exhibited maximum radical scavenging activity with IC50 13.4 μg/mL, while compound 4 exhibited maximum tyrosinase with IC50 39.4 μg/mL. All the isolates showed moderate urease inhibition.
Quantification of Uncertainty in the Master Curves of Viscoelastic Properties of Asphalt Concrete
Authors: Rema Aswathy , Swamy Aravind Krishna 
Published: January 2018

Abstract
The prediction of asphalt concrete (AC) behavior using a continuum damage mechanics approach requires viscoelastic properties like creep compliance (CC) and relaxation modulus (RM) values. Because of practical limitations, dynamic modulus (DM) and phase angle (PA) measurements are used to construct CC and RM master curves. Numerous approximate interconversion techniques have been used for this purpose. Because of issues during testing, fabrication processes, and interconversion approximations, significant scatter can be found in CC- and RM-constructed master curves. The present study proposes and compares quantification methods to address scatter found in CC and RM master curves. The scatter found in CC and RM master curves at different reduced time values is quantified using uncertainty quantification (UQ) techniques. For this purpose, several AC specimens with identical volumetric properties were prepared and tested for DM and PA values. Furthermore, CC and RM master curves were obtained using DM and PA through approximate interconversion techniques. Finally, CC and RM values obtained (at a fixed time using particular simulation techniques) with all specimens were combined. Using these values, scatter in CC and RM values (at a specific reduced time) was evaluated using UQ techniques. The results indicate that the choice of simulation technique affects the statistical parameters associated with probability density function (PDF) to a large extent. This, in turn, significantly affects the shape of the PDF at a chosen reduced time of interest. In other words, uncertainty found in CC and RM values are dependent on the choice of interconversion technique and time of interest.
Dopamine Development in the Mouse Orbital Prefrontal Cortex Is Protracted and Sensitive to Amphetamine in Adolescence
Authors: Hoops Daniel , Reynolds Lauren M. , Restrepo-Lozano Jose-Maria , Flores Cecilia 
Published: January 2018

AbstractThe prefrontal cortex (PFC) is divided into subregions, including the medial and orbital prefrontal cortices. Dopamine connectivity in the medial PFC (mPFC) continues to be established throughout adolescence as the result of the continuous growth of axons that innervated the nucleus accumbens (NAcc) prior to adolescence. During this period, dopamine axons remain vulnerable to environmental influences, such as drugs used recreationally by humans. The developmental trajectory of the orbital prefrontal dopamine innervation remains almost completely unstudied. Nonetheless, the orbital PFC (oPFC) is critical for some of the most complex functions of the PFC and is disrupted by drugs of abuse, both in adolescent humans and rodents. Here, we use quantitative neuroanatomy, axon-initiated viral-vector recombination, and pharmacology in mice to determine the spatiotemporal development of the dopamine innervation to the oPFC and its vulnerability to amphetamine in adolescence. We find that dopamine innervation to the oPFC also continues to increase during adolescence and that this increase is due to the growth of new dopamine axons to this region. Furthermore, amphetamine in adolescence dramatically reduces the number of presynaptic sites on oPFC dopamine axons. In contrast, dopamine innervation to the piriform cortex is not protracted across adolescence and is not impacted by amphetamine exposure during adolescence, indicating that dopamine development during adolescence is a uniquely prefrontal phenomenon. This renders these fibers, and the PFC in general, particularly vulnerable to environmental risk factors during adolescence, such as recreational drug use.
An Autophagy-Independent Role for ATG41 in Sulfur Metabolism During Zinc Deficiency
Authors: Bucci Michael D , Weisenhorn Erin , Haws Spencer , Yao Zhiyuan , Zimmerman Ginelle , Gannon Molly , Taggart Janet , Lee Traci , Klionsky Daniel J , Russell Jason , Coon Joshua , Eide David J 
Published: January 2018

Abstract
The Zap1 transcription factor of Saccharomyces cerevisiae is a key regulator in the genomic responses to zinc deficiency. Among the genes regulated by Zap1 during zinc deficiency is the autophagy-related gene ATG41. Here, we report that Atg41 is required for growth in zinc-deficient conditions, but not when zinc is abundant or when other metals are limiting. Consistent with a role for Atg41 in macroautophagy, we show that nutritional zinc deficiency induces autophagy and that mutation of ATG41 diminishes that response. Several experiments indicated that the importance of ATG41 function to growth during zinc deficiency is not because of its role in macroautophagy, but rather is due to one or more autophagy-independent functions. For example, rapamycin treatment fully induced autophagy in zinc-deficient atg41Δ mutants but failed to improve growth. In addition, atg41Δ mutants showed a far more severe growth defect than any of several other autophagy mutants tested, and atg41Δ mutants showed increased Heat Shock Factor 1 activity, an indicator of protein homeostasis stress, while other autophagy mutants did not. An autophagy-independent function for ATG41 in sulfur metabolism during zinc deficiency was suggested by analyzing the transcriptome of atg41Δ mutants during the transition from zinc-replete to -deficient conditions. Analysis of sulfur metabolites confirmed that Atg41 is needed for the normal accumulation of methionine, homocysteine, and cysteine in zinc-deficient cells. Therefore, we conclude that Atg41 plays roles in both macroautophagy and sulfur metabolism during zinc deficiency.
Multisite Emergency Department Inpatient Collaborative to Reduce Unnecessary Bronchiolitis Care
Authors: Mussman Grant M. , Lossius Michele , Wasif Faiza , Bennett Jeffrey , Shadman Kristin A. , Walley Susan C. , Destino Lauren , Nichols Elizabeth , Ralston Shawn L. 
Published: January 2018

BACKGROUND AND OBJECTIVES:
There is high variation in the care of acute viral bronchiolitis. We sought to promote collaboration between emergency department (ED) and inpatient (IP) units with the goal of reducing unnecessary testing and treatment.

METHODS:
Multisite collaborative with improvement teams co-led by ED and IP physicians and a 1-year period of active participation. The intervention consisted of a multicomponent change package, regular webinars, and optional coaching. Data were collected by chart review for December 2014 through March 2015 (baseline) and December 2015 to March 2016 (improvement period). Patients &lt;24 months of age with a primary diagnosis of bronchiolitis and without ICU admission, prematurity, or chronic lung or heart disease were eligible for inclusion. Control charts were used to detect improvement. Achievable benchmarks of care were calculated for each measure.

RESULTS:
Thirty-five hospitals with 5078 ED patients and 4389 IPs participated. Use of bronchodilators demonstrated special cause for the ED (mean centerline shift: 37.1%–24.5%, benchmark 5.8%) and IP (28.4%–17.7%, benchmark 9.1%). Project mean ED viral testing decreased from 42.6% to 25.4% after revealing special cause with a 3.9% benchmark, whereas chest radiography (30.9%), antibiotic use (6.2%), and steroid use (7.6%) in the ED units did not change. IP steroid use decreased from 7.2% to 4.0% after special cause with 0.0% as the benchmark. Within-site ED and IP performance was modestly correlated.

CONCLUSIONS:
Collaboration between ED and IP units was associated with a decreased use of unnecessary tests and therapies in bronchiolitis; top performers used few unnecessary tests or treatments.
Identifikasi Patahan Menggunakan Analisis Data Deformasi Tanah di Tapak RDE Serpong
Authors: Suntoko Hadi , Sriyana Sriyana 
Published: January 2018

AbstrakTapak Reaktor Daya Eksperimental (RDE) terletak di Serpong berjarak ± 67 km dari sesar aktif Cimandiri. Hasil evaluasi tapak menunjukkan bahwa tapak RDE layak dan aman dari patahan aktif. Namun, diperlukan pemantauan deformasi batuan menggunakan alat Global Positioning System (GPS). Tujuannya adalah mendapatkan koordinat teliti melalui data GPS untuk mengidentifikasi ada tidaknya aktivitas patahan dan pengaruh patahan terhadap tapak. Pemantauan menggunakan konfigurasi enam titik ukur yang memotong jalur yang diduga sebagai patahan berarah tenggara-baratlaut. Metode penelitian menggunakan pendataan koordinat titik stasiun GPS berkala BATAN dan titik stasiun GPS kontinyu BIG dalam radius 25 km. Pengolahan data menggunakan perangkat lunak Bernese Versi 5.2 dilakukan secara radial dari titik stasiun 1 sebagai titik referensi dan dilanjutkan intepretasi data. Hasil analisis menunjukkan bahwa kondisi patahan/tektonik sekitar tapak RDE berada di kisaran 0,05 mikrostrain yang merupakan daerah dengan kondisi tektonik stabil. AbstractExperimental Power Reactor (EPR) site is located in Serpong and it has a distance of ± 67 km from the Cimandiri active fault. Result of EPR site evaluation show that it is feasible and safe from the active fault. However, it is necessary to monitor the rock deformation by using Global Positioning System(GPS) tool. The goal is to obtain precise coordinates through GPS data to identify the presence of active fault activity and its impact on the site. The monitoring is using six measuring points configuration mounted crossing the southeast-northwest suppose fault line direction. The research method is using coordinate data collection from BATAN GPS periodic station and BIG GPS continuous station in radius 25 km. Data processing is using Bernese Version 5.2 Software, proceed radially from station 1 as reference point and then continued by data interpretation. The Analysis result shows that the fault/tectonic condition near EPR site is in the range of 0.05 microstrain which is an area with stable tectonic condition.
Frequência de alterações posturais em hemofílicos
Authors: Santos Rafaele Serra , Figueirôa Giovana Rossi , Machado Brenda de Araújo , Mamede Carlos André Gomes Silva , Gois Lúcia Maria Leandro , Silva Junior Mário Cezar Macêdo 
Published: January 2018

INTRODUÇÃO: A hemofilia é uma doença crônica de origem genética causada por uma mutação dos genes que codificam os fatores de coagulação sanguíneos. Uma das consequências dessa alteração é o acometimento do sistema musculoesquelético, o que pode influenciar na postura desses indivíduos. OBJETIVO: Estimar a frequência de alterações posturais em portadores de hemofilia, e identificar possíveis fatores associados. MÉTODOS: Estudo descritivo de corte transversal, conduzido com indivíduos com idade ? 18 anos, com diagnóstico de hemofilia, em acompanhamento na Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Os participantes foram submetidos à avaliação postural, por meio da análise visual, teste de Adams e aplicação de um formulário semi-estruturado. Empregou-se o Epi Info® (v.3.5.2) para análise dos dados e, para verificar a existência de associações entre as variáveis do estudo foram utilizados os Testes exato de Fisher, Qui-quadrado (bicaudal) e Qui-Quadrado com a correção de Yates. Consideradas como estatisticamente significantes associações com p <0,05. RESULTADOS: Participaram deste estudo 29 hemofílicos, com média de idade de 34,9 ± 12,6 anos, 25 (86,2%) informaram ter artropatia hemofílica. Dos participantes da pesquisa 13 (68,4%) apresentaram postura escoliótica detectada pelo teste de Adams. A alteração foi mais frequente nos indivíduos com mais de uma articulação afetada pela artropatia hemofílica, com valor estatisticamente significativo para esta variável (p= 0,039). CONCLUSÃO: As frequências de alterações posturais em indivíduos com hemofilia são elevadas com associação significativa para os indivíduos com idade superior a 40 anos e com mais de uma articulação afetada pela artropatia hemofílica.
The use of cellular technologies in the treatment of children with congenital cleft palate
Authors: Stepanova Yulia V. , Tsyplakova Margarita S. , Usoltseva Anna S. , Enukashvili Natela I. , Bagaeva Varvara V. , Semyonov Mikhail G. , Murashko Tatiana V. , Ponamareva Karina G. 
Published: January 2018

Background. Mesenchymal stromal cells (MSCs) are multipotent stem cells capable of differentiation in the osteogenic, chondrogenic, and adipogenic directions that are widely used in the development of new cellular biomedical technologies.
Aim. We investigated the effect of MSCs on osteogenesis in the congenital defect of the alveolar process of the upper jaw with the aim of improving the treatment results for children with congenital cleft palate.
Materials and methods. At the department of maxillofacial surgery of the Turner Institute for Children’s Orthopedics, 46 patients with a diagnosis of congenital cleft palate were observed in 2017. Six patients with congenital cleft palate in the region of the defect of the hard palate and the alveolar process of the upper jaw underwent uranoplasty and implantation of a mixture (1 : 4) of MSCs and preosteocytes derived from them on the osteogenic membrane. The control group consisted of 40 age-matched patients who underwent the same surgery but without the use of MSCs. The distance between the cleaved portions of the alveolar process of the upper jaw ranged from 0.5–1.0 cm. The follow-up period was 6–9 months.
Results. On X-ray examination 6–9 months after the operation in the bone defect area and implantation of MSCs in all patients, tissue with a density corresponding to that of bone was found. In the control group, bone tissue was not formed in the diastasis of the alveolar bone. There were no significant differences in the timing of wound healing and course of the postoperative period.
Сonclusion. Tissue engineering helped in the treatment of severe congenital malformations of the maxillofacial area. There are good prospects for using MSCs in the surgical treatment of defects of the facial skeleton.
Treatment of pediatric patients with lower leg deformities associated with physeal arrest: analysis of 28 cases
Authors: Vilensky Viktor A. , Pozdeev Andrey A. , Zubairov Timur F. , Zakharyan Ekaterina A. 
Published: January 2018

Aim. To retrospectively analyze the results of two treatment methods for lower leg deformities associated with partial growth arrest.
Materials and methods. Group I comprised 15 children who underwent osteotomy, acute overcorrection, and external fixation by Ilizarov with subsequent lengthening of the segment. Group II comprised 13 patients who underwent epiphysiodesis of the healthy part of the growth plate by drilling, osteotomy with external fixation by use of an Ortho-SUV Frame, and subsequent gradual deformity correction and lengthening.
Results. In group I, overcorrection of varus deformities by mechanical axis deviation (MAD) was 18.28 ± 5.25 mm, overcorrection by mechanical medial proximal tibial angle (mMPTA) was 14.86 ± 4.45°, and overcorrection by mechanical lateral distal tibial angle (mLDTA) was 12.85 ± 3.02°. Overcorrection of valgus deformities according to MAD was 15.12 ± 8.28 mm, overcorrection by mMPTA was 10.38 ± 2.77°, and overcorrection by mLDTA was 7.5 ± 3.9°. Recurrence of the deformity was observed in 11 (73%) cases (range, 5–16 months).
In group II, the accuracy of correction (AC) in varus deformities for MAD was 98% and 94% for mMPTA and mLDTA. For valgus deformities, AC for MAD was 90% and 96% for mMPTA and mLDTA. The AC for anatomical proximal posterior tibial angle and anatomical anterior distal tibial angle was 96% for procurvation deformities and that for recurvation deformities was 92%. Deformity recurrence was observed in only one case within 6 months after frame removal. In 2 cases, repeat limb length discrepancy correction surgeries were performed.
Conclusion. Use of epiphysiodesis of the healthy portion of the growth plate in combination with osteotomy, computer-assisted external fixation with subsequent gradual deformity correction, and lengthening in patients with deformities associated with partial physeal arrest significantly decreased the number of deformity recurrences.
Peluang dan Tantangan Pemanfaatan Frekuensi Ka-Band untuk Sistem Komunikasi Satelit [Opportunities and Challenges upon Usage of Ka-band Frequency for Satellite Communication System]
Authors: Pradono Wirianto 
Published: January 2018

Data traffic growth is much higher than that of voice traffic. Cisco predicts that mobile data traffic in Indonesia will grow 8- fold from 2016 to 2021. Broadband technology becomes appropriate solution to cope with data traffic growth and to keep quality of service optimal. Considering that terrain profile of rural areas in Indonesia is hard for terrestrial system to be deployed, satellite technology is urgently required to deploy broadband services in rural areas. Considering its superiorities over existing satellite systems, Ka-band satellite is one of key technologies to enable broadband service penetration in rural area. Literature studies and qualitative approach are used in this study to identify opportunities and challenges Indonesia will encounter when deploying Ka-band satellite system. Research results show that Ka-band satellite is capable of facilitating telecommunication services requiring high bandwidth. Satellite service users also vary, spanning from industries, government agencies, and consumers. Regardless superiorities Ka-band satellite offers, there are still some challenges to address. Those challenges are vulnerability of Ka-band frequency due to rain attenuation and lack of Ka-band filing owned by Indonesia with status approved by International Telecommunication Union (ITU). *****Pertumbuhan trafik data jauh melampaui pertumbuhan trafik suara. Cisco memprediksi trafik data bergerak di Indonesia akan meningkat sebesar 8 kali lipat dalam periode 2016-2021. Teknologi pitalebar merupakan solusi tepat untuk memfasilitasi peningkatan trafik data sekaligus menjaga kualitas layanan tetap optimal. Kondisi medan wilayah rural Indonesia sulit dijangkau oleh sistem terestrial sehingga teknologi satelit sangat dibutuhkan agar penetrasi layanan pitalebar dapat menjangkau wilayah tersebut. Menimbang sejumlah keunggulan dari satelit Ka-band dibandingkan sistem satelit yang ada saat ini membuat satelit Ka-band menjadi salah satu teknologi kunci yang memungkinkan penetrasi layanan pitalebar hingga wilayah rural. Studi literatur dan pendekatan kualitatif digunakan dalam studi ini untuk mengidentifikasi potensi dan tantangan yang dihadapi Indonesia dalam pengembangan sistem satelit Ka-band. Hasil studi menunjukkan satelit Ka-band mampu memfasilitasi layanan telekomunikasi yang membutuhkan bandwidth besar. Pengguna layanan satelit juga bervariasi meliputi industri, institusi pemerintah, hingga konsumen individu dan rumah tangga. Meskipun satelit Ka-band menawarkan sejumlah keunggulan, ada beberapa tantangan yang harus diantisipasi yakni kerentanan frekuensi Ka-band terhadap redaman hujan dan ketiadaan filing Ka-band milik Indonesia dengan status disetujui oleh International Telecommunication Union (ITU).
Interpreting Neonatal Growth Parameters in Oman: Are we doing it right?
Authors: Abdulrahim Reem M. , Idris Ahmed B. , Ur-Rahman Asad , Abdellatif Mohamed , Fuller Nigel 
Published: January 2018

Objectives: This study aimed to compare reference anthropometric measures of Omani neonates with the international standard growth charts of the World Health Organization (WHO) in order to determine the appropriateness of these growth charts to assess the growth of Omani neonates. Methods: This cross-sectional study included all healthy full-term Omani neonates born between November 2014 and November 2015 at the Sultan Qaboos University Hospital, Muscat, Oman. Birth weight, length and head circumference measurementswere identified and compared to those of the 2006 WHO growth charts. Results: A total of 2,766 full-term neonates were included in the study, of which 1,401 (50.7%) were male and 1,365 (49.3%) were female. Mean birth weightsfor Omani males and females were 3.16 ± 0.39 kg and 3.06 ± 0.38 kg, respectively; these were significantly lower than the WHO standard measurements (P <0.001). Similarly, the mean head circumferences of Omani males and females (33.8 ± 1.27 cm and 33.3 ± 1.26 cm, respectively) were significantly lower than those reported in the WHO growth charts (P <0.001). In contrast, mean lengths for Omani males and females (52.0 ± 2.62 cm and 51.4 ± 2.64 cm, respectively) were significantly higher than the WHO standard measurements (P <0.001). Conclusion: The WHO growth charts might not be appropriate for use with Omani neonates; possible alternatives should thereforebe considered, such as national growth charts based on local data.
Mortality Rate and Years of Life Lost Due to Prostate Cancer in Yazd Province, Iran: A 10-year study
Authors: Mirzaei Mojtaba , Mirzadeh Mahboobehsadat , Mirzaei Mohsen 
Published: January 2018

Objectives: Prostate cancer is a leading cause of cancer-related deaths. The number of deaths and years of life lost (YLL) due to a disease can be used to monitor health status, assess healthcare needs and determine the prioritisation and allocation of health resources within a population; in addition, the latter calculation can serve as a baseline indicator of premature mortality. This study aimed to measure prostate cancer-related mortality and YLL in Yazd Province, Iran. Methods: This study included all prostate cancer-related deaths in Yazd Province reported between March 2001 and March 2010. Mortality data were obtained from a provincial death registration system which integrates data from different sources. YLL was calculated based on an individual’s age at death and their life expectancy according to age group. Results: During the study period, prostate cancer was the fourth most common fatal cancer among men, resulting in 324 deaths or 10.0% of all cancer-related deaths. The crude mortality rate per 100,000 individuals increased from 4.7 in 2001 to 8.8 in 2010. Premature deaths caused 1,358.7 YLL and the YLL caused by prostate cancer deaths more than doubled from 94.7 in 2001 to 196.5 in 2010. Conclusion: Due to changes in population structure, it is likely that the burden of prostate cancer will continue to increase in Yazd Province. As such, it is necessary that the national health system implements screening programmes and improvespublic awareness of prostate cancer-associated risk factors.