bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of rectal indomethacin, diclofenac, and naproxen for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis
Authors: Mohammad Alizadeh Amir H. , Abbasinazari Mohammad , Hatami Behzad , Abdi Saeed , Ahmadpour Forozan , Dabir Shideh , Nematollahi Aida , Fatehi Samira , Pourhoseingholi Mohammad A. 
Published: November 2016

Background and aim
NSAIDs are commonly utilized for the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). However, not much is known about the most effective drug in preventing this complication. This study aims to clarify which drug (indomethacin, diclofenac, or naproxen) is most effective for the prevention of post endoscopic retrograde cholangiopancreatography (ERCP).

Materials and methods
In a double-blind, randomized study, patients received a single rectal dose of one of the three drugs 30 min before undergoing ERCP: diclofenac (100 mg), indomethacin (100 mg), or naproxen (500 mg). The primary outcome measured was the development of pancreatitis. The levels of serum amylase, lipase, lipoxin A4, and resolvin E1 were measured before ERCP, and at 24 h after the procedure.

Results
Three hundred and seventy-two patients completed the study. The overall incidence of PEP was 8.6%, which occurred in five of the 124 (4%) patients who received diclofenac, seven of the 122 (5.8%) patients who received indomethacin, and 20 of the 126 (15.9%) patients who received naproxen. There were no significant differences in amylase and lipase levels among the three groups (P=0.183 and 0.597, respectively). Unlike patients in the naproxen group, patients in the diclofenac and indomethacin groups showed a significant increase in lipoxin A4 and resolvin E1 (P=0.001 and 0.02, respectively).

Conclusion
Diclofenac and indomethacin patient groups had a lower incidence of PEP than the naproxen group.
Patients Negatively Impacted by Discontinuity of Nursing Care During Acute Hospitalization
Authors: Yakusheva Olga , Costa Deena K. , Weiss Marianne 
Published: November 2016

Background:
Continuity of nursing care in hospitals remains poor and not prioritized, and we do not know whether discontinuous nursing care is negatively impacting patient outcomes.

Objectives:
This study aims to examine nursing care discontinuity and its effect on patient clinical condition over the course of acute hospitalization.

Research Design:
Retrospective longitudinal analysis of electronic health records (EHR). Average point-in-time discontinuity was estimated from time of admission to discharge and compared with theoretical predictions for optimal continuity and random nurse assignment. Mixed-effects models estimated within-patient change in clinical condition following a discontinuity.

Subjects:
A total of 3892 adult medical-surgical inpatients were admitted to a tertiary academic medical center in the Eastern United States during July 1, 2011 and December 31, 2011.

Measures:
Exposure: discontinuity of nursing care was measured at each nurse assessment entry into a patient’s EHR as assignment of the patient to a nurse with no prior assignment to that patient. Outcome: patient’s clinical condition score (Rothman Index) continuously tracked in the EHR.

Results:
Discontinuity declined from nearly 100% in the first 24 hours to 70% at 36 hours, and to 50% by the 10th postadmission day. Discontinuity was higher than predicted for optimal continuity, but not random. Each instance of discontinuity lead to a 0.12–0.23 point decline in the Rothman Index score, with more pronounced effects for older and high-mortality risk patients.

Conclusions:
Discontinuity in acute care nurse assignments was high and negatively impacted patient clinical condition. Improved continuity of provider-patient assignment should be advocated to improve patient outcomes in acute care.
Nonmodifiable risk factors for anterior cruciate ligament injury
Authors: Price Meghan J. , Tuca Maria , Cordasco Frank A. , Green Daniel W. 
Published: November 2016

Purpose of reviewAs anterior cruciate ligament (ACL) injury is becoming increasingly prevalent in the population of active children and young adolescents, it is crucial to be aware of both the modifiable and nonmodifiable factors that place this population at increased ACL injury risk. Historically, there has not been a definitive consensus on all of these risk factors—particularly the nonmodifiable ones.Recent findingsThe present review has accumulated the most recent evidence for the nonmodifiable risk factors in ACL injury focusing particularly on female gender, generalized joint laxity, knee recurvatum, increased lateral tibial slope, decreased intercondylar notch width, structural lower extremity valgus, limb length discrepancy, family history, and history of contralateral knee ACL injury.SummaryPhysicians should be aware of the nonmodifiable risk factors for ACL tears in active children and adolescents and should also encourage avoidance of modifiable risk factors in this population. Young athletes with nonmodifiable risk factors are at a particularly increased risk of recurrent injury following ACL reconstruction (ACLR). We believe that a primary extra-articular augmentation via iliotibial band tenodesis at the same time of ACLR may decrease the rate of reinjury for the high risk athlete with multiple nonmodifiable risk factors.
Childhood Bladder and Bowel Dysfunction Questionnaire
Authors: van Engelenburg‐van Lonkhuyzen Marieke L. , Bols Esther M.J. , Bastiaenen Caroline H.G. , Benninga Marc A. , de Bie Rob A. 
Published: November 2016

ABSTRACTObjectives:The aim of the study was to develop a questionnaire evaluating the frequency of symptoms over time of concomitant childhood bladder and bowel dysfunctions (CBBDs) in 5‐ to 12‐year‐old children and to assess its feasibility and aspects of validity and reliability.Methods:The Childhood Bladder and Bowel Dysfunction Questionnaire (CBBDQ) was developed in phases according to COnsensus‐based Standards for the selection of health Measurement Instruments (COSMIN) in cooperation with epidemiologists, pediatricians, physiotherapists (phases 1 and 5), and professional translators (phase 5): selection of items (Delphi‐method), content validity (pilot), feasibility (interviews), structural validity and internal consistency (field testing), and guideline‐based translation (Dutch‐English). Participants were parents of children, ages 5 to 12 years (phases 2–4).Results:Parents of 1333 children (mean age 7.8 years [standard deviation 2.1]) were included. Most common were urinary incontinence (35.9%), enuresis (29.7%), and constipation/fecal incontinence (30.1%). Concomitant CBBD was seen in 74.2% of 1229 children. Originally, a 27‐item CBBDQ was developed. After the pilot (48 parents) a 23‐item version remained for evaluation of feasibility aspects by interviewing 56 parents. Based on 1229 completed questionnaires during field testing, the CBBDQ reduced to 18 items. Cronbach α values were 0.74 and 0.71 for bladder and bowel subscales, respectively. Feasibility and aspects of validity and reliability were satisfactory. A definitive and accepted English version of the CBBDQ is available.Conclusions:When completed by parents, the 18‐item evaluative CBBDQ appears feasible, content, and structurally valid with good internal consistency for the bladder and bowel subscales. The Dutch and English versions will be introduced clinically and subjected to further psychometric evaluation.
Nutrient‐enriched Infant Formula Is Associated With Higher Weight Gain for Low Birth Weight Infants
Authors: Ngan Michelle , Durazo‐Arvizu Ramon , Weiss Marc G. , Kramer Holly 
Published: November 2016

ABSTRACTObjective:Nutrient‐enriched formulas were developed to provide extra nutrients and facilitate optimal growth for low birth weight infants. This study examined the association between use of nutrient‐enriched formulas and weight gain among low birth weight infants (birth weight 1500–2500 g).Methods:This retrospective cohort study used data from infants enrolled in the Illinois Special Supplemental Nutrition Program for Women, Infants, and Children. Analyses were limited to infants born in 2010 with low birth weight (1500–2500 g, n = 3130). We examined weight gain by use of nutrient‐enriched versus standard term formula, which was assigned to the infant by the Women, Infants, and Children program during the first month of life. The analyses used a multilevel mixed‐effects linear regression model with random intercepts to determine the association between use of enriched versus standard term formula and weight gain while simultaneously adjusting for confounders including gestational age, birth weight, and history of breast‐feeding.Results:Among 670 infants in the 1500 to 1999 g birth weight group, those fed enriched formula gained 46.4 g (95% confidence interval 7.4–85.3, P < 0.05) more per month in the first 6 months, and 34.0 g (95% confidence interval −0.4 to 68.3, P = 0.05) more per month >6 to 12 months of age compared with infants using standard term infant formula after adjustment for covariates. Similar findings were noted among the 2460 infants in the 2000 to 2500 g birth weight group.Conclusions:Use of nutrient‐enriched formulas is associated with higher weight gain in low birth weight infants.
Use of CA-125 Tests and Computed Tomographic Scans for Surveillance in Ovarian Cancer
Authors: Esselen Katharine M. , Cronin Angel M. , Bixel Kristin , Bookman Michael A. , Burger Robert A. , Cohn David E. , Cristea Mihaela , Griggs Jennifer J. , Levenback Charles F. , Mantia-Smaldone Gina , Meyer Larissa A. , Matulonis Ursula A. , Niland Joyce C. , Sun Charlotte , O’Malley David M. , Wright Alexi A. 
Published: November 2016

(Abstracted from JAMA Oncol 2016; DOI: 10.1001/jamaoncol.2016.1842)
Data from a clinical trial presented at the 2009 American Society of Clinical Oncology Annual Meeting and published in 2010 compared results among patients with ovarian cancer in clinical remission, who were randomized to either active surveillance with cancer antigen 125 (CA-125) testing or clinical observation. Findings from this trial demonstrated that routine surveillance with CA-125 testing increased use of chemotherapy and decreased patients’ quality of life without improving survival.
Zika and the Risk of Microcephaly
Authors: Johansson Michael A. , Mier-y-Teran-Romero Luis , Reefhuis Jennita , Gilboa Suzanne M. , Hills Susan L. 
Published: November 2016

(Abstracted from N Engl J Med 2016;375:1–4)
During an outbreak in 2013–2014, the rate of Zika virus (ZIKV) infection in the Polynesian population was estimated at a rate of 66%, and it was estimated that it posed a risk of microcephaly in the first trimester of pregnancy of 0.95% (95% confidence interval [CI], 0.34%–1.91%). In order to estimate the risk of microcephaly in the recent Brazilian outbreak, where Zika infection rates are not known, a range of 10% to 80% of ZIKV infection rates were estimated in Bahia.
Anti-Ro and Concomitant Anti-La Autoantibodies Strongly Associated With Anti-oxLDL or Anti-Phospholipid Antibody in Systemic Lupus Erythematosus
Authors: Kurien Biji Theyilamannil , Fesmire James , Anderson Camille Jean , Scofield Robert Hal 
Published: November 2016

Background
Premature atherosclerosis is observed in systemic lupus erythematosus (SLE). Oxidative modification of LDL is associated with atherosclerotic plaque formation.

Objectives
We hypothesized that anti-oxidized LDL (oxLDL) and anti-phospholipid (APL) in SLE sera would segregate with specific antibody subsets, and that anti-oxLDL antibodies will linger in circulation over an extended period.

Patients and Methods
Sixty-seven SLE and control subjects and two SLE subjects with sera collected longitudinally for 13 years were tested for anti-oxLDL and IgG/IgM/IgA APL antibodies.

Results
Anti-oxLDL ELISA values above 57.48 Activity Units (AcU) (means of normals + 3 standard deviations) and anti-IgG/IgM/IgA APL above 10 phospholipid units (PU) were considered positive. Average anti-oxLDL was 67.7 ± 50.5 AcU in SLE compared to 23.9 ± 11.19 AcU in normals (P = 0.018). Ten out of ten subjects with anti-Ro60/anti-La/anti-Ro52 antibodies had highly significant (P < 0.0001) anti-oxLDL (127.29 ± 45.67 AcU) and IgG APL (18.66 ± 7.4 PU) (P < 0.02). Subjects with anti-RNP were positive for anti-oxLDL (P < 0.002), but subjects with anti-Ro60/anti-Ro52 and subjects negative for extractable nuclear antigen (ENA) antibody were not positive for anti-oxLDL. Anti-oxLDL/anti-IgG APL remained significantly elevated in two patients studied longitudinally. Interestingly, one developed anti-oxLDL/anti-APL antibodies several years before anti-Ro60 development.

Conclusions
Presence of antibodies against Ro RNP and La, and RNP is highly associated with developing anti-oxLDL and APL antibodies in SLE. It will be clinically important to see if cardiovascular events occur in these SLE subsets having elevated anti-oxLDL and APL antibodies. Emergence of anti-oxLDL/IgG APL before anti-Ro60 over time in a patient indicates that these antibodies could not be cross-reactive in nature, at least in this particular patient.
Improved Delineation of Pulmonary Embolism and Venous Thrombosis Through Frequency Selective Nonlinear Blending in Computed Tomography
Authors: Bongers Malte Niklas , Bier Georg , Kloth Christopher , Schabel Christoph , Fritz Jan , Nikolaou Konstantin , Horger Marius 
Published: November 2016

Objective
The aim of this study was to test the hypothesis that a novel frequency selective nonlinear blending (NLB) algorithm increases the delineation of pulmonary embolism and venous thrombosis in portal-venous phase whole-body staging computed tomography (CT).

Materials and Methods
A cohort of 67 patients with incidental pulmonary embolism and/or venous thrombosis in contrast-enhanced oncological staging CT were retrospectively selected. Computed tomography data sets were acquired 65 to 90 seconds after intravenous iodine contrast administration using state-of-the-art multi-detector CT scanners. A novel frequency selective NLB postprocessing technique was applied to reconstructed standard CT images. Two readers determined the most suitable settings to increase the delineation of pulmonary embolism and venous thrombosis. Outcome measure included region of interest and contrast-to-noise ratio (CNR) analyses, image noise, overall image quality, subjective delineation, as well as number and size of emboli and thrombi. Statistical testing included quantitative comparisons of Hounsfield units of thrombus and vessel, image noise and related CNR values and subjective image analyses of image noise, image quality and thrombus delineation, number and size in standard, and NLB images.

Results
Using frequency selective NLB settings with a center of 100 HU, delta of 40 HU, and a slope of 5, CNR values of pulmonary embolism (StandardCNR, 10 [6, 16]; NLBCNR, 22 [15, 30]; P < 0.001) and venous thrombosis (StandardCNR, 8 [5, 15]; NLBCNR, 12 [7, 19]; P = 0.0007) increased. Mean vascular enhancement using NLB was significantly higher than in standard images for pulmonary arteries (Standard, 138 [118, 191] HU; NLB, 269 [176, 329] HU; P < 0.0001) and veins (Standard, 120 [103, 162] HU; NLB, 169 [132, 217] HU; P < 0.0001), respectively. Image noise was not significantly different between standard and NLB images (P = 0.64-0.88). There was substantial to almost perfect interrater agreement as well as a significant increase of overall image quality (P < 0.004) and subjective delineation of the thrombotic material (P < 0.0001) in both subgroups. Nonlinear blending images revealed 8 additional segmental and 13 subsegmental emboli. Thrombus sizes were not significantly different, but subjective accuracy of the measurement could be significantly increased using NLB (P = 0.03).

Conclusions
Postprocessing of standard whole-body staging CT images with frequency selective NLB improves image quality and the delineation of pulmonary embolism and venous thrombosis.
Can Nodular Hyperplasia of the Thyroid Gland be Differentiated From Follicular Adenoma and Follicular Carcinoma by Ultrasonography?
Authors: Jeong Sun Hye , Hong Hyun Sook , Lee Eun Hye 
Published: November 2016

ObjectivesThe aim of this study was to evaluate the ultrasonographic features for differentiation of follicular thyroid lesions.MethodsUltrasonographic features of surgically confirmed 56 follicular adenoma (FA), 22 follicular carcinoma (FC), and 100 nodular hyperplasia (NH) were evaluated using univariable and multivariable multinomial logistic regression analyses, receiver operating characteristic analyses, and areas under the curve.ResultsTumor diameter, margin, echotexture, cystic changes, calcification, hypoechoic rim, and vascularity were significant on univariable analysis. On multivariable logistic regression analyses, tumor diameter (FA,P= 0.002; odds ratio [OR], 0.75; FC,P= 0.001; OR, 2.02), absence of cystic changes (FA,P= 0.127; OR, 2.21; FC,P≤ 0.001; OR, 17.74), absence of spongiform appearance (FA,P= 0.234; OR, 0.31; FC,P< 0.001; OR,  1673.46), and peripheral vascularity (FA,P= 0.004; OR, 26.64; FC,P< 0.001; OR, 145060.38) differed significantly among the 3 follicular lesions, with NH as a reference. The areas under the curve for NH, FA, and FC were 0.844, 0.858, and 0.705, respectively, and diagnostic accuracy was 72.6%.ConclusionsTumor diameter, cystic changes, spongiform appearance, and peripheral vascularity differed significantly among follicular lesions. The diagnostic capability was moderate.
Structural and functional brain changes following four weeks of unimanual motor training: evidence from fMRI-guided diffusion MRI tractography
Authors: Reid Lee B , Sale Martin V , Cunnington Ross , Mattingley Jason B , Rose Stephen E 
Published: November 2016

AbstractWe have reported reliable changes in behaviour, brain structure and function in 24 healthy right-handed adults who practiced a finger-thumb opposition sequence task with their left hand for 10 mins daily, over four weeks. Here we extend these findings by employing diffusion MRI to investigate white-matter changes in the corticospinal tract, basal-ganglia, and connections of the dorsolateral prefrontal cortex. Twenty-three participant datasets were available with pre-training and post-training scans. Task performance improved in all participants (mean: 52.8%, SD: 20.0%; group p<0.01 FWE) and widespread microstructural changes were detected across the motor system of the ‘trained’ hemisphere. Specifically, region-of-interest based analyses of diffusion MRI (n=21) revealed significantly increased fractional anisotropy in the right caudate nucleus (4.9%; p<0.05 FWE), and decreased mean diffusivity in the left nucleus accumbens (-1.3%; p<0.05 FWE). Diffusion MRI tractography (n=22), seeded by sensorimotor cortex fMRI activation, also revealed increased fractional anisotropy in the right corticomotor tract (mean 3.28%; p<0.05 FWE) predominantly reflecting decreased radial diffusivity. These changes were consistent throughout the entire length of the tract. The left corticomotor tract did not show any changes. FA also increased in white matter connections between the right middle frontal gyrus and both right caudate nucleus (17/22 participants; p<0.05 FWE) and right supplementary motor area (18/22 participants; p<0.05 FWE). Equivalent changes in FA were not seen in the left (‘non-trained’) hemisphere. In combination with our functional and structural findings, this study provides detailed, multifocal evidence for widespread neuroplastic changes in the human brain resulting from motor training.
Liabilities of regionalization and the emerging market firm
Authors: Kelley Keith J. 
Published: November 2016

PurposeThe purpose of this paper is to revisit the causal relationships of the liabilities of inter-regional foreignness to show that the process of regionalization itself has affected firms’ strategic capabilities and focus. The constraints of these regions, a consequence of regionalization that limits the strategic options of multinational enterprises, are known as the liabilities of regionalization (LOR).Design/methodology/approachThis study reviews previous literature and uses a mixture of theory and inference to make propositions regarding the existence of liabilities attributable to the regionalization process. The propositions discuss macro-level, and industry and firm-level strategic impact on firms of Triad and non-Triad regions.FindingsIt is argued specific emerging market attributes, in relation to the developed Triad regions, will influence strategic focus of those emerging market firms. This in turn will also influence global strategic behavior and capabilities in the future, creating additional LOR in some cases and reducing them in others.Originality/valuePrevious scholars have focused on the liabilities of inter-regional and regional foreignness and its effect on international diversification strategy both upstream and downstream. This study attempts to explain the formation of regions that shape the FSAs that limit global strategic diversification, which are characterized as the LOR. More importantly, it discusses them from perspective of emerging market firms, which on the outside of the Triad regions, may form their own regions and FSAs.
International Financial Reporting Standards, board governance, and accounting quality
Authors: Krismiaji  , Aryani Y. Anni , Suhardjanto Djoko 
Published: November 2016

PurposeThe purpose of this paper is to discuss empirical research examining the impact of International Financial Reporting Standard (IFRS) adoption and board governance on the accounting quality, in terms of relevance and faithful representation.Design/methodology/approachThe research uses a sample of 454 observations of publicly listed companies on the Indonesian Stock Exchange for the fiscal year that ends on December 31, 2008 through 2011. Relevance is measured by predictive value, whereas faithful representation is measured by absolute discretionary accrual as an inverse measure. Board governance is measured by the board of commissioner score whereas IFRS adoption is measured by the percentage of IFRS adopted. The data used in this study are obtained both from Indonesian Capital Market Directory, Indonesian Stock Exchange database, and from company annual reports.FindingsThis research found evidence of a positive association of IFRS adoption on the relevance of accounting information quality. With respect to faithful representation, this study proves a positive association after IFRS adoption. This research also found that board governance has a positive impact on accounting information quality after IFRS adoption both in relevance and faithful representation. This result is in line with investor’s expectations that fair value IFRS adoption enhances the relevance of accounting information.Originality/valueThis study provides further evidence on the effect of IFRS adoption and board of governance on accounting information quality using data from Indonesia. Moreover, this study measures and tests both dimensions of earnings quality which are relevance and faithful representation and portrays a complete story about the quality of earnings. This study uses the qualitative characteristics of accounting information as proxies for accounting quality, so that it enriches the accounting literature about the role of accounting standards in financial reporting quality.