bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differences in Relative Iron Bioavailability in Traditional Bangladeshi Meal Plans
Authors: DellaValle Diane M. , Glahn Raymond P. 
Published: November 2015

Background Iron deficiency is the most common nutrient deficiency worldwide. Large intakes of micronutrient-poor staple crops, coupled with low intakes of highly bioavailable dietary iron, are a major cause of this deficiency. Objective To examine the concentration and relative bioavailability of iron in several models ( n = 23) of traditional Bangladeshi meals (rice, lentils/dal, vegetable, and fish), as well as the effect of removal of the lentil seed coat on the nutritional quality of iron. Methods The relative bioavailability of iron was assessed by the in vitro/Caco-2 cell culture method, iron concentration by an inductively coupled argon-plasma emission spectrometer (ICAP-ES), and phytic acid concentration by colorimetric assay. The recipes contained 75% to 85% rice, 0% to 15% dal (containing whole or dehulled lentils), 0% to 15% vegetable curry, and 0% to 8% fish. Results While the iron concentrations of recipes containing dehulled dal were significantly lower than those of recipes containing whole dal ( p = .005), seed coat removal doubled relative iron bioavailability and increased phytic acid concentration ( p < .001). The addition of fish to the meals had no significant effect on relative iron bioavailability. Iron concentration and relative iron bioavailability were correlated in the recipes containing dehulled dal ( r = 0.48, p = .03), but not whole dal ( r = −0.047, p = .84). Conclusions The total amount of iron absorbed from traditional Bangladeshi meals is dependent upon iron concentration, and dehulling lentils removes inhibitory factors increasing iron uptake but also increases the density of phytic acid in the lentil sample. Thus, along with breeding for high iron concentration and bioavailability (i.e., biofortification), seed coat removal plus measures to lower phytic acid concentrations may be an important strategy to improve the bioavailability of iron in lentils and other pulse crops.
Nutrition Education and Introduction of Broad Bean—Based Complementary Food Improves Knowledge and Dietary Practices of Caregivers and Nutritional Status of Their Young Children in Hula, Ethiopia
Authors: Negash Canaan , Belachew Tefera , Henry Carol J. , Kebebu Afework , Abegaz Kebede , Whiting Susan J. 
Published: November 2015

Background Nutritious complementary foods are needed in countries where undernutrition and stunting are major problems, but mothers may be reluctant to change from traditional gruels. Objective To test whether a recipe-based complementary feeding education intervention would improve knowledge and practice of mothers with young children in Hula, Ethiopia. Methods A baseline survey of 200 eligible, randomly selected mother—child pairs gathered data on sociodemographic characteristics, food security status, knowledge and practices concerning complementary feeding, food group intakes of children aged 6 to 23 months by 24-hour recalls, and children's anthropometric measurements. Twice a month for 6 months, women in the intervention group received an education session consisting of eight specific messages using Alive and Thrive posters and a demonstration and tasting of a local barley and maize porridge recipe containing 30% broad beans. The control group lived in a different area and had no intervention. Results At 6 months, knowledge and practice scores regarding complementary feeding were significantly improved ( p < .001) in the intervention group but not in the control group. The intervention resulted in improvement of children's dietary diversity, as well as mean intake of energy and selected nutrients, compared with children in the control group. Changes in height and weight did not differ between the two groups. Conclusions Community-based nutrition education over 6 months that included demonstration of a local porridge recipe with broad beans added improved the complementary feeding practices of caregivers and the nutritional status of their young children.
“Cooking and Active Leisure” TAS Program, Spain: A Program Impact Pathways (PIP) Analysis
Authors: Roura Elena , Pareja Sara Lucía , Milà Raimon , Cinca Núria 
Published: November 2015

Background The “Cooking and Active Leisure” Tu y Alícia por la Salud (CAL-TAS) Program is a school-based pilot that addresses healthy lifestyle needs of Spanish secondary school students with initiatives that research has proven to improve dietary and physical activity behaviors. Objective The objectives were to perform a Program Impact Pathways (PIP) analysis to describe key activities and processes of the CAL-TAS Program, identify Critical Quality Control Points (CCPs), and identify a suite of common indicators of healthy lifestyles to be applied across participant schools. Methods The CAL-TAS Program designers and implementation team developed this PIP analysis through an iterative process and presented the results for feedback at the seven-country Healthy Lifestyles Program Evaluation Workshop held in Granada, Spain, 13–14 September 2013, under the auspices of the Mondelēz International Foundation. Results The team identified three PIP CCPs: teachers' motivation and training, changes in students' knowledge of healthy lifestyles, and changes in students' healthy lifestyle behavior. The selected indicators of the program's impact on healthy lifestyles are adequacy of food intake, level of knowledge of healthy lifestyles gained, and adequacy of physical activity level according to World Health Organization recommendations. A clear definition of impact indicators, as well as collection of accurate data on healthy lifestyle behaviors and knowledge, is essential to understanding the effectiveness of this program before it can be scaled up. Conclusions CAL-TAS is an effective secondary school-based program encouraging healthy lifestyles. The PIP analysis was instrumental in identifying CCPs to sustain and improve the quality of the program. The team hopes to sustain and improve the program through these program evaluation recommendations.
Management of Acute Malnutrition in Infants Aged under 6 Months (MAMI): Current Issues and Future Directions in Policy and Research
Authors: Kerac Marko , Mwangome Martha , McGrath Marie , Haider Rukhsana , Berkley James A. 
Published: November 2015

Background Globally, some 4.7 million infants aged under 6 months are moderately wasted and 3.8 million are severely wasted. Traditionally, they have been overlooked by clinicians, nutritionists, and policy makers. Objective To present evidence and arguments for why treating acute malnutrition in infants under 6 months of age is important and outline some of the key debates and research questions needed to advance their care. Methods Narrative review. Results and conclusions Treating malnourished infants under 6 months of age is important to avoid malnutrition-associated mortality in the short term and adverse health and development outcomes in the long term. Physiological and pathological differences demand a different approach from that in older children; key among these is a focus on exclusive breastfeeding wherever possible. New World Health Organization guidelines for the management of severe acute malnutrition (SAM) include this age group for the first time and are also applicable to management of moderate acute malnutrition (MAM). Community-based breastfeeding support is the core, but not the sole, treatment. The mother—infant dyad is at the heart of approaches, but wider family and community relationships are also important. An urgent priority is to develop better case definitions; criteria based on mid-upper-arm circumference (MUAC) are promising but need further research. To effectively move forward, clinical trials of assessment and treatment are needed to bolster the currently sparse evidence base. In the meantime, nutrition surveys and screening at health facilities should routinely include infants under 6 months of age in order to better define the burden and outcomes of acute malnutrition in this age group.
Environmental Enteric Dysfunction: An Overview
Authors: Crane Rosie J. , Jones Kelsey D. J. , Berkley James A. 
Published: November 2015

Background Environmental enteric dysfunction (EED) refers to an incompletely defined syndrome of inflammation, reduced absorptive capacity, and reduced barrier function in the small intestine. It is widespread among children and adults in low- and middle-income countries. Understanding of EED and its possible consequences for health is currently limited. Objective A narrative review of the current understanding of EED: epidemiology, pathogenesis, therapies, and relevance to child health. Methods Searches for key papers and ongoing trials were conducted using PUBMED 1966–June 2014; ClinicalTrials. gov; the WHO Clinical Trials Registry; the Cochrane Library; hand searches of the references of retrieved literature; discussions with experts; and personal experience from the field. Results EED is established during infancy and is associated with poor sanitation, certain gut infections, and micronutrient deficiencies. Helicobacter pylori infection, small intestinal bacterial overgrowth (SIBO), abnormal gut microbiota, undernutrition, and toxins may all play a role. EED is usually asymptomatic, but it is important due to its association with stunting. Diagnosis is frequently by the dual sugar absorption test, although other biomarkers are emerging. EED may partly explain the reduced efficacy of oral vaccines in low- and middle-income countries and the increased risk of serious infection seen in children with undernutrition. Conclusions Despite its potentially significant impacts, it is currently unclear exactly what causes EED and how it can be treated or prevented. Ongoing trials involve nutritional supplements, water and sanitation interventions, and immunomodulators. Further research is needed to better understand this condition, which is of likely crucial importance for child health and development in low- and middle-income settings.
Metabolomics in Nutrition Research: Biomarkers Predicting Mortality in Children with Severe Acute Malnutrition
Authors: Freemark Michael 
Published: November 2015

Background Millions of the world's children suffer from malnutrition, which predisposes to death from diarrhea and a variety of infectious diseases. Mortality rates among infants and toddlers remain staggeringly high, in part because the pathogenesis of acute malnutrition and its complications remains poorly understood. Objective We used metabolomic analysis to characterize the metabolic status of Ugandan children with severe acute malnutrition (SAM) and to delineate changes in hormones, metabolites, growth factors, and cytokines during nutritional therapy. We hypothesized that hormonal and metabolic factors measured at presentation would associate with, or predict, subsequent mortality during treatment Methods This was a prospective cohort study of 75 severely malnourished children 6 months to 5 years of age treated as inpatients with F-75 and F-100 and supplemental micronutrients; after discharge, they received ready-to-use therapeutic food (RUTF). This increased the mean weight-for-height z-score (WHZ) from −4.27 to −1.75 SD. Blood samples were obtained at presentation, after 2 weeks of inpatient therapy, and after 4 to 10 weeks of RUTF. Plasma samples were analyzed by tandem mass spectrometry and microassays. Results At presentation there were high levels of non-esterified fatty acids (NEFA), ketones, and even-chain acylcarnitines, indicating active lipolysis and fatty acid oxidation. In contrast, albumin, amino acids, and C3 carnitine, a by-product of branched-chain amino acids, were low. Levels of insulin, insulin-like growth factor 1 (IGF-1), adiponectin, and leptin were low, while levels of ghrelin, growth hormone, cortisol, interleukin 6 (IL-6), peptide YY (PYY), and glucagon-like peptide 1 (GLP-1) were high. The metabolic and hormonal changes were reversed by formula feeding and RUTF. Biomarkers associated with mortality included HIV, WHZ, and mid-upper-arm circumference (MUAC); the biochemical factor associated most strongly with mortality was low leptin, a marker of adipose reserve and modulator of immune function. Conclusions Low leptin predicts mortality in edematous and nonedematous patients with SAM. Leptin assays might be used to identify malnourished children at highest risk for death.
Everyday Stressors of Academically Gifted Adolescents
Authors: Baker Jean A. 
Published: November 2015

This study evaluated everyday “hassles” and other stressors experienced by academically gifted, exceptionally academically gifted, and academically average adolescents. The results suggest that gifted and non-gifted adolescents experienced similar levels and types of everyday stressors. However, exceptional and to some degree gifted girls endorsed more perfectionistic tendencies than did their average peers. The need for affective education and psychosocial interventions for gifted students in schools is discussed. Adolescence is a time of increased stress for all youth. Educators of the gifted have had a long and enduring concern about the special stressors and pressures affecting gifted adolescents (e.g., Hollingworth, 1942; Seeley, 1993). Although gifted students are often posited to have strong psychosocial characteristics (e.g., Clark, 1988), we also have documentation that giftedness can generate stress and conflict for some students (e.g., Whitmore, 1980). Although we might expect high levels of stress from gifted students experiencing psychosocial or educational difficulties (i.e., underachieving gifted students), we have little normative information about problems and strains experienced by “typical” gifted adolescents. This study focused on specific stressors endorsed by academically gifted adolescents and compared them to those endorsed by their peers of average academic ability.
The Development of Math Talent: Influences on Students at a Women's College
Authors: Gavin M. Katherine 
Published: November 2015

An examination of the distribution of women who earn doctorates in mathematics and science presents a picture of uneven advancement. Women are clustered in the life sciences with far fewer majoring in the physical sciences, mathematics, engineering, and computer sciences. Recent studies attempting to identify factors that influence a woman's choice of career in the mathematical fields have focused on either women who have completed doctorates or formal training in their chosen fields or women presently in graduate programs in mathematics. This study focuses on math majors still in college, specifically 16 females at a highly selective liberal arts women's college, and factors that influenced their choice of this major and future career plans. A qualitative research methodology was employed using questionnaires, interviews with the students and the mathematics faculty, participant observation in mathematics classrooms, and document reviews of college and departmental publications. Findings revealed that positive school experiences and certain shared personality characteristics were integral in students' decisions to continue the study of mathematics in college.
Betty's Story
Authors: Sanders Michael 
Published: November 2015

This life history is created within the context of a larger study. Purposeful sampling was used to identify six college-aged, self-identified intellectuals from a group of students in a University Scholars program at a large university. The group included three men and three women all around 20 years old. Multiple interviews with member checks were used to create textual data from each participant. Participants discussed personal independence, the desire to learn, the meaning of the term “intellectual,” attitudes toward schooling, their teachers, educational programs for intellectually gifted students, social and cultural interests, their personal lives, and other topics. The analysis of the data used textual information from the interviews combined with information from sociological and anthropological sources to situate the participants' life stories in social, historical, and cultural contexts thereby creating life histories. A life lived is what actually happens. A life experienced consists of the images, feelings, desires, thoughts, and meanings known to the person whose life it is … A life as told, a life history, is a narrative, influenced by the cultural conventions of telling, by the audience, and by the social context (Denzin, 1989, p. 30).
Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis
Authors: Gernez Yael , Waters Jeffrey , Mirković Bojana , Lavelle Gillian M. , Dunn Colleen E. , Davies Zoe A. , Everson Cassie , Tirouvanziam Rabindra , Silver Elana , Wallenstein Sylvan , Chotirmall Sanjay H. , McElvaney Noel G. , Herzenberg Leonore A. , Moss Richard B. 
Published: November 2015

The diagnosis of cystic fibrosis (CF) patients with allergic bronchopulmonary aspergillosis (ABPA) is clinically challenging, due to the absence of an objective biological test. Since blood basophils play a major role in allergic responses, we hypothesised that changes in their surface activation pattern discriminate between CF patients with and without ABPA.We conducted a prospective longitudinal study (Stanford cohort) comparing basophil activation test CD203c levels by flow cytometry before and after activation withAspergillus fumigatusallergen extract or recombinantAspf1 in 20 CF patients with ABPA (CF-ABPA) and in two comparison groups: CF patients withA. fumigatuscolonisation (AC) but without ABPA (CF-AC; n=13) and CF patients without either AC or ABPA (CF; n=12). Patients were tested every 6 months and when ill with pulmonary exacerbation. We also conducted cross-sectional validation in a separate patient set (Dublin cohort).Basophil CD203c surface expression reliably discriminated CF-ABPA from CF-AC and CF over time. Ex vivostimulation withA. fumigatusextract or recombinantAspf1 produced similar results within the Stanford (p<0.0001) and the Dublin cohorts. CF-ABPA patients were likelier to have elevated specific IgE toA. fumigatusand were less frequently co-infected withStaphylococcus aureus.Basophil CD203c upregulation is a suitable diagnostic and stable monitoring biomarker of ABPA in CF.
Pedagogical Competence in Interaction with the Pupils&#180; Families
Authors: ��������  , Simakova Tatiana , ������  , Meychik Galina 
Published: November 2015

The article shows transition actuality from paternalistic to the partner paradigm of cooperation school with families of student. The competence of the
teaching staff should play a key role in this transition. In the article there is a structure and content of pedagogical competence related to partnerships
with the families of the students on the basis of competence approach. Motivational, cognitive and operational components of competence are represented
by a set of indicators. The school administration and the teachers will be able to get an idea of the level of competence of partner interaction in this
pedagogical collective, based on the presented here structure and content of competence. In addition, this article provides methods for the formation of
the competence of the teacher in the educational institution.
A Simple Heuristic for Joint Inventory and Pricing Models with Lead Time and Backorders
Authors: Bernstein Fernando , Li Yang , Shang Kevin 
Published: November 2015

We study a joint inventory and pricing problem in a single-stage system with a positive lead time. We consider both additive and multiplicative demand forms. This problem is, in general, intractable due to its computational complexity. We develop a simple heuristic that resolves this issue. The heuristic involves a myopic pricing policy that generates each period’s price as a function of the initial inventory level and a base-stock policy for inventory replenishment. In each period, the firm monitors its so-called price-deflated inventory position and places an order to reach a target base-stock level. The price-deflated inventory position weights the on-hand and pipeline inventory according to a factor that reflects the sensitivity of price to the net inventory level. To assess the effectiveness of our heuristic, we construct an upper bound to the exact system. The upper bound is based on an information-relaxation approach and involves a penalty function derived from the proposed heuristic. A numerical study suggests that the heuristic is near-optimal. The heuristic approach can be applied to a wide variety of inventory systems, such as systems with fixed ordering costs or fixed batch sizes. The heuristic enables us to explore the use of price as a lever to balance supply and demand. Our findings indicate that a responsive strategy (that effectively reduces the replenishment lead time) leads to a more stable pricing policy and that the value of dynamic pricing increases with lead time. This paper was accepted by Martin Lariviere, operations management.
The Eleatic and the Indispensabilist
Authors: Marcus Russell 
Published: November 2015

The debate over whether we should believe that mathematical objects exist quickly leads to the question of how to determine what we should believe. Indispensabilists claim that we should believe in the existence of mathematical objects because of their ineliminable roles in scientific theory. Eleatics argue that only objects with causal properties exist. Mark Colyvan’s recent defenses of Quine’s indispensability argument against some contemporary eleatics attempt to provide reasons to favor the indispensabilist’s criterion. I show that Colyvan’s argument is not decisive against the eleatic and sketch a way to capture the important intuitions behind both views.
The Stress Check Program: a new national policy for monitoring and screening psychosocial stress in the workplace in Japan
Authors: Kawakami Norito , Tsutsumi Akizumi 
Published: November 2015

The Stress Check Program: a new national policy for monitoring and screening psychosocial stress in the workplace in Japan: Norito Kawakami, et al. Department of Mental Health, School of Public Health, The University of TokyoObjectiveThe Japanese government launched a new occupational health policy called the Stress Check Program. This program mandates that all workplaces with 50 or more employees conduct the Stress Check Program for workers at least once a year. This article gives a brief overview and critical review of the program.MethodsWe reviewed relevant laws, guidelines, and manuals, as well as the policy development process. The policy and the components of the program were compared using available scientific evidence and trends in the management of psychosocial factors at work according to the policies and guidelines of international bodies and European countries.ResultsThe process of program policy development was based on a discussion among employer and employee representatives, occupational health professionals, and mental health experts. Scientific evidence shows that mandated components of the program (i.e., feedback of stress survey results and physician's interview) may be ineffective. However, additional components recommended to employers, such as stress management skill provision and work environment improvement, in conjunction with the program may be effective in improving psychosocial stress at work. The Stress Check Program is unique compared with the global trend for psychosocial risk management because it focuses on the assessment of stress among individual workers.ConclusionThe new program may be effective in improving worker mental health by facilitating the psychosocial risk management approach in Japan. Concerns regarding the program include mass leakage of collected information, and possible disadvantages for workers labeled as having high stress.