bluuebunny/crossref_metadata_2025_split huggingface dataset:
STRUCTURAL CHARACTERISTICS AND ANTIHYPERTENSIVE EFFECTS OF ANGIOTENSIN-ICONVERTING ENZYME INHIBITORY PEPTIDES IN THE RENIN-ANGIOTENSIN AND KALLIKREIN KININ SYSTEMS
Authors: Manoharan Sivananthan , Shuib Adawiyah Suriza , Abdullah Noorlidah 
Published: March 2017

Background: The commercially available synthetic angiotensin-I-converting enzyme (ACE) inhibitors are known to
exert negative side effects which have driven many research groups globally to discover the novel ACE inhibitors.
Method: Literature search was performed within the PubMed, ScienceDirect.com and Google Scholar.
Results: The presence of proline at the C-terminal tripeptide of ACE inhibitor can competitively inhibit the ACE
activity. The effects of other amino acids are less studied leading to difficulties in predicting potent peptide sequences.
The broad specificity of the enzyme may be due to the dual active sites observed on the somatic ACE. The inhibitors
may not necessarily competitively inhibit the enzyme which explains why some reported inhibitors do not have the
common ACE inhibitor characteristics. Finally, the in vivo assay has to be carried out before the peptides as the
antihypertensive agents can be claimed. The peptides must be absorbed into circulation without being degraded, which
will affect their bioavailability and potency. Thus, peptides with strong in vitro IC50 values do not necessarily have the
same effect in vivo and vice versa.
Conclusion: The relationship between peptide amino acid sequence and inhibitory activity, in vivo studies of the active
peptides and bioavailability must be studied before the peptides as antihypertensive agents can be claimed.
SPATHOLOBUS SUBERECTUS STEM EXTRACT IMPROVES THE PROTECTIVE EFFECT OF HEPARIN ON CERULEIN–INDUCED PANCREATITIS
Authors: Shao Zhengyi 
Published: March 2017

of pancreatitis alone and in combination with heparin.
Material and methods: Pancreatitis was induced pancreatitis by cerulean (50μg/kg, i.p.) five times at an interval of 1 h
without any pretreatment of drug. Rats were treated with SS (100 and 200 mg/kg, p. o.) and heparin (150 U/kg, i.p.)
alone and in combination for the duration of a week. Later pancreatic weight and blood flow was estimated and
different biochemical parameters like concentration of D-dimer and Interleukin 1β (IL-1β) and activity of amylase and
lipase were determined in blood of pancreatitis rats. Moreover effect of drug treatment on DNA synthesis and
histopathology was also estimated on cerulean induced pancreatitis rats.
Result: Results of this study suggest that treatment with SS alone and in combination with heparin significantly
increase in prothrombin time and pancreatic blood flow than negative control group. There was significant decrease in
concentration of IL-1β and D-dimer and activity of amylase and lipase in SS and heparin treated group than negative
control group. Pancreatic DNA synthesis was also found to be reduced in SS and heparin alone and in combination
treated group. Histopathology study also reveals that treatment with SS and heparin alone and in combination reduces
edema, hemorrhages, leukocyte infiltration in the TS of pancreatic tissues. Conclusion: Present study concludes that
treatment with SS alone effectively manages the pancreatitis by ceasing the inflammatory pathway and potentiates the
effect of heparin in the management of pancreatitis.
ANTIMICROBIAL ACTIVITY OF BURSERA MORELENSIS RAMÍREZ ESSENTIAL OIL
Authors: Canales-Martinez M. , Rivera-Yañez C.R , Salas-Oropeza J. , Lopez H.R , Jimenez-Estrada M. , Rosas-Lopez R. , Duran D.A. , Flores C , Hernandez L.B , Rodriguez-Monroy M.A 
Published: March 2017

Background: Bursera morelensis, known as “Aceitillo”, is an endemic tree of Mexico. Infusions made from the bark of this species have been used for the treatment of skin infections and for their wound healing properties. In this work, we present the results of a phytochemical and antimicrobial investigation of the essential oil of B. morelensis.
Materials and Methods: The essential oil was obtained by a steam distillation method and analyzed using GC-MS. The antibacterial and antifungal activities were evaluated.
Results: GC-MS of the essential oil demonstrated the presence of 28 compounds. The principal compound of the essential oil was α-Phellandrene (32.69%). The essential oil had antibacterial activity against Gram positive and negative strains. The most sensitive strains were S. pneumoniae, V. cholerae (cc) and E. coli (MIC 0.125 mg/mL, MBC 0.25 mg/mL). The essential oil was bactericidal for V. cholera (cc). The essential oil inhibited all the filamentous fungi. F. monilifome (IC50 = 2.27 mg/mL) was the most sensitive fungal strain.
Conclusions: This work provides evidence that confirms the antimicrobial activity of the B. morelensis essential oil and this is a scientific support about of traditional uses of this species.
Medición multidimensional de la pobreza: estado de la cuestión y aplicación al ODS-1
Authors: Larrú Ramos José María 
Published: March 2017

Este artículo presenta una revisión de las opciones métricas disponibles para lograr que el Objetivo de Desarrollo Sostenible 1, contenido en la Agenda 2030 de Desarrollo Sostenible aprobada por Naciones Unidas en 2015, sea realmente universal y comprometa a todos los países, no solo a los denominados países en desarrollo. Dado que la segunda meta de dicha Agenda propone “reducir al menos a la mitad la proporción de hombres, mujeres y niños de todas las edades que viven en pobreza en todas sus dimensiones con arreglo a las definiciones nacionales” el artículo cobra sentido e importancia al ofrecer un panorama de las experiencias que ya existen sobre medición de pobreza multidimensional incluyendo las de América Latina y de Europa. Partiendo de la metodología común de Alkire y Foster que superan algunas de las limitaciones de la tradicional línea de pobreza monetaria,se evidencia que existe una oportuna flexibilidad de elección en dimensiones, umbrales, ponderaciones y líneas de corte divisorias entre pobres y no pobres.
Intraemprendimiento incluyente, modelo de sostenibilidad de empleo y cooperación en el Centro de Emprendimiento Pedro Romero
Authors: Taylor Abello Raúl 
Published: March 2017

Se indagó sobre la implementación de un diseño de intraemprendimiento incluyente financiado por cooperación internacional en Colombia, específicamente que genere acceso a los mercados de bienes y servicios para las unidades productivas constituidas por personas vulnerables de la Red Unidos y No unidos que se encuentren formalizadas en la Red Cemprende. La investigación es de tipo mixto: cualitativo y cuantitativo, con la metodología estudio de caso. Los resultados de la investigación evidenciaron la ausencia de apoyo de la empresa privada y del sector oficial en acciones concretas para afianzar una política pública-privada en el Distrito Turístico y Cultural de Cartagena de Indias que permita el acceso a nuevos mercados a través del diseño de un modelo de intraemprendimiento y de garantía a un proceso constante de la Cooperación Internacional para el Desarrollo. Se concluyó que a partir de la problemática planteada, el modelo de intraemprendimiento incluyente inició a partir de las necesidades de la demanda, las empresas de Cartagena y los consumidores finales están en capacidad de adquirir bienes y servicios según la calidad de la oferta de las unidades productivas.
Cooperación internacional y emigración calificada: diáspora científica colombiana
Authors: Angulo Pico Grace Margarita 
Published: March 2017

Este documento esboza avances investigativos en torno a la relación de la diáspora científica colombiana y la cooperación internacional en Ciencia, Tecnología e Innovación (CTeI). Metodológicamente, se realizó una búsqueda en fuentes documentales de información, con objeto de desarrollar un estado del arte preliminar; presentar el marco institucional correspondiente y describir el proceso emigratorio del capital humano especializado, resaltando su evolución histórica y países de destino. Se destaca que Colciencias, ente rector en materia de investigación e innovación de Colombia, no dispone de canales oficiales de comunicación con la diáspora. Adicional, la información disponible sobre emigrantes calificados es limitada, lo que sugiere que por lo menos en el corto plazo, será difícil implementar políticas efectivas de repatriación cuya finalidad sea atraer los nacionales con mayores calificaciones residentes en el extranjero.
EFEKTIVITAS PELATIHAN KURIKULUM PENDIDIKAN ANAK USIA DINI DI KECAMATAN GRABAG
Authors: Fauziarti Benni Farida , Soedarsono FX. 
Published: March 2017

Penelitian bertujuan untuk mengetahui keefektifan pelatihan kurikulum PAUD dilihat dari empat variabel, yaitu reaksi peserta terhadap pelatihan, pemahaman materi, perubahan perilaku, dan dampak di lembaga asal. Jenis penelitian adalah evaluasi dengan menerapkan model evaluasi Kirkpatrick. Populasi penelitian meliputi seluruh peserta pelatihan sebanyak 43 peserta. Teknik sampling yang digunakan adalah teknik sensus, yakni meliputi seluruh ang-gota populasi. Teknik pengumpulan data yang digunakan adalah inventori, wawancara, observasi, dan dokumentasi. Untuk mengetahui validitas dan reliabilitas instrumen, digunakan analisis faktor, uji koefisien Alpha, dan reliabilitas kombinasi linier. Teknik analisis data adalah analisis deskriptif dan analisis jalur. Hasil penelitian menunjukkan bahwa pelatihan kurikulum efektif. Keefektifan tersebut ditunjukkan oleh hasil kontribusi tiga level terhadap level akhir dan skor tinggi yang diperoleh para peserta pada semua variabel penelitian serta didukung oleh hasil wawancara dan observasi. Namun variabel yang memberikan kontribusi secara signifikan terhadap dampak di lembaga hanyalah variabel pemahaman materi sebanyak 15,6% dan variabel perubahan perilaku sebesar 9,5%.Kata kunci: efektivitas pelatihan THE EFFECTIVENESS OF THE TRAINING OF EARLY CHILDHOOD EDUCATION CURRICULUM IN GRABAG DISTRICTAbstractResearch aims to know effectiveness of of the training of early childhood education curriculum viewed from four variables, namely reaction participants against training, understanding matter, behavior modifications, and impact in an institution origin.The kind of research is evaluation by applying model evaluation kirkpatrick. Population research over all the trainees 43 participants. Sampling techniques used is technique census, namely covering all members of the population.Technical data used is inventori, interview observation, and documentation.To know validity and reliabilitas instrument, used of factor analysis, test coefficient alpha, and reliabilitas combination linear. The technique of data analysis were descriptive analysis and path analysis.The result showed that training curriculum is effective. The effectiveness is showed by the contribution of three levels to the last level and based on the high scores obtained by the participants on all study variables and also supported by interview and obervation results. However, the variables that provide the significant impact on the institution is only the variables of understanding the material as much as 15.6% and the variable of behavior change by 9.5%.Keywords: the effectiveness of training
PENGGUNAAN MEDIA PEMBELAJARAN PLASTISIN UNTUK MENINGKATKAN KREATIVITAS ANAK USIA
Authors: Kartini Kartini , Sujarwo Sujarwo 
Published: March 2017

Penelitian ini bertujuan untuk mengetahui: (1) perbedaan kreativitas anak usia dini pada pembelajaran sebelum dan sesudah menggunaka media plastisin, (2) perbedaan kreativitas antara kelompok anak yang diajarkan dengan media plastisin dan media balok di TK Aisyiyah Bustanul Athfal 5 Mataram. Jenis penelitian yang digunakan adalah penelitian kuasi eksperimen dengan desain pretest-posttest control group design. Teknik observasi digunakan untuk mengetahui kreativitas anak. Teknik analisis data menggunakan uji T-test. Hasil penelitian menunjukan bahwa: (1) ada perbedaan kreativitas anak usia dini pada pembelajaran sebelum dan sesudah menggunakan media plastisin. (2) ada perbedaan yang signifikan mengenai kreativitas anak antara kelompok eksperimen dengan kelompok kontrol. Perolehan mean kreativitas eksperimen lebih besar dari pada mean kelompok kontrol yaitu 37,00 > 31,17. Hasil uji-t data posttest kemampuan kreativitas kelompok kontrol dan kelompok eksperimen menunjukkan bahwa nilai t-tabel dengan derajat bebas (df) 34 dengan taraf signifikansi α = 0,05 adalah sebesar 2,032. Nilai t- hitung 3,389 > t-tabel 2,032 dan nilai p-value 0,000< taraf signifikansi 0,05.Kata Kunci: penggunaan, media plastisin, kreativitas anak usia dini THE USE OF PLASTISIN MEDIA IN IMPROVING CHILDREN CREATIVITYAbstractThis research aims to know: (1) there are the differences of early childhood creativity of learning before and after using Plastisin, (2) the differences of creativity in learning by using Plastisin and Block of children group at TK Aisyiyah Bustanul Athfal 5 Mataram. This research used quasi-experiment with pretest-posttest control group design. The data collection technique used observation. Analysis data technique was done with T-test. The result of the research was (1) There are differences of early childhood creativities in learning before and after using plastisin media. (2) There are significance differences between creativities the experiment and control group. Creativity experiment mean was bigger than control group 37.00 > 31.17. The result of T-test data from post-test, the creativity ablity of control and experiment group showed that t-table with standard deviation (df) 34 with significance α = 0.05 was 2.032. t-count score 3.389>t-table 2.032 and p-value 0.000 < significance 0.05.Keywords: the use of, plastisin media, children creativity.
PENINGKATAN KETERAMPILAN BERBICARA ANAK USIA DINI MELALUI PERMAINAN SANDIWARA BONEKA
Authors: Shofa Mila Faila , Suparno Suparno 
Published: March 2017

Penelitian ini bertujuan untuk: (1) mengimplementasikan kegiatan permainan sandiwara boneka dalam mengembangkan keterampilan berbicara peserta didik di PAUD SAYMARA Kartasura kelompok A, (2) meningkatkan keterampilan berbicara anak usia dini melalui permainan sandiwara boneka di PAUD SAYMARA Kartasura kelompok A. Jenis penelitian ini adalah Penelitian Tindakan Kelas. Subjek dalam penelitian ini adalah anak didik kelompok A di PAUD SAYMARA Kartasura tahun ajaran 2013/2014. Penelitian ini bersifat kolaboratif antara peneliti, guru kelas, dan kepala sekolah. Data dikumpulkan melalui observasi, catatan lapangan, wawancara, dan dokumentasi. Data dianalisis secara deskriptif kualitatif model alur. Hasil penelitian ini menunjukkan bahwa (1) implementasi permainan sandiwara boneka meliputi kegiatan awal, kegiatan inti, dan kegiatan penutup. Kegiatan awal berupa apersepsi dan pengenalan tokoh, pada kegiatan inti guru menunjukkan permainan sandiwara boneka, dan kegiatan akhir peserta didik menceritakan kembali dengan permainan sandiwara boneka. (2) permainan sandiwara boneka dapat meningkatkan keterampilan berbicara anak usia dini. Peningkatan prosentase keterampilan berbicara dari sebelum tindakan sampai dengan siklus II yakni sebelum tindakan 40,13 %, siklus I mencapai 61,08 %, siklus II mencapai 79,74 %.Kata kunci: keterampilan berbicara, anak usia dini, permainan sandiwara boneka. IMPROVING EARLY CHILD SPEAKING SKILLS THROUGH PUPPET PLAYSAbstractThe study aims to: (1) implement puppet play activities in developing speaking skills in PAU Improving Early Child Speaking Skills through Puppet Plays (A Classroom Action Research in PAUD Kartasura SAYMARA Group A in the Academic Year of 2013/2014 )D SAYMARA Kartasura group A, and (2) improve speaking skills in early child through puppet plays in PAUD SAYMARA Kartasura group A.This research is Classroom Action Research. The subjects in this study are students in PAUD SAYMARA group A Kartasura in the Academic Year of 2013/2014. This research is a collaborative research, between researcher, classroom teachers, and school headmaster. Data validity were checked by triangulation. Data were analyzed by descriptive qualitative flow models. The results indicate that (1) the implementation of puppet play include first activity, core activity, and closing activity. First activity include apperception and character recognition, teacher show the puppet plays in the core activity, and the final activity student retell the puppet plays. (2) puppet plays can improve speaking skills in early child. The percentage of speaking skills in pre cycle is 40.13 %, in first cycle 61.08 % and in the second is 79.74 %.Keywords: speaking skills, early child, puppet plays
Pemberdayaan perempuan melalui pelatihan pengolahan bahan pangan lokal
Authors: Saugi Wildan , Sumarno Sumarno 
Published: March 2017

Penelitian ini bertujuan untuk mengetahui pelatihan pengolahan bahan pangan lokal yang dapat memberdayakan warga perempuan dusun Pagerjirak, Kejobong, Purbalingga. Penelitian ini merupakan participatory action research (PAR) dengan pendekatan kualitatif dan kuantitatif. Subjek penelitian terdiri dari kepala dusun, tujuh anggota tim pengelola dusun, dan 15 warga perempuan dusun. Data penelitian diperoleh dengan teknik observasi, wawancara, dan dokumentasi. Hasil penelitian adalah sebagai berikut. (1) Perencanaan partisipatoris terdiri dari identifikasi kebutuhan dusun dan penyiapan tim pengelola program dusun. (2) Pelaksanaan proses pemberdayaan melalui pelatihan dimulai dengan menyiapkan tim pengelola, membentuk kelompok usaha, menjalin kemitraan dengan pihak pemerintah dan swasta, membangun rumah produksi, mengajukan izin produksi, produksi dan pemasaran produk, melakukan studi banding ke industri rumah tangga, melakukan perbaikan dan diversifikasi produk, dilanjutkan dengan pelatihan massal, dan pendampingan. (3) Indikator keberhasilan pelatihan diantaranya adalah bertambahnya pengetahuan dan keterampilan warga, serta diperolehnya pendapatan hasil usaha penjualan produk. (4) Keberlanjutan program pemberdayaan perempuan ditunjukkan dengan telah adanya pengembangan produk atau variasi produk dan terbentuknya kemandirian tim.Kata Kunci: pemberdayaan perempuan, pelatihan, bahan pangan lokal Woman Empowerment Through Local Produce Processing TrainingsAbstractThis research aims to reveal the local produce processing that can empower women in Pagerjirak, Kejobong, Purbalingga. This research was participatory action research with the qualitative and quantitative approach. The research subject consisted of the village chief, core team consisting of seven people, and 15 women in the village. The research data were obtained through observations, interviews, and documentation. The results of research are as follows. (1) The participatory planning consists of need analysis and preparing management team. (2) The training processes are conducted by preparing the management team, building the business unit, creating relation with the government and private sectors, building production houses, applying for production permits, producing and marketing, comparative study to home industry, reflecting, improving, and diversifying product, holding massive, and mentoring. (3) The indicators of a successful training are the improvement of knowledge and skills of women, and the profit of product sales. (4) The sustainability of women empowerment program are product development or diversification and the management team becomes more and more independent.Keywords: woman empowerment, training, local produce
Partisipasi masyarakat dalam penyelenggaraan program-program pusat kegiatan belajar masyarakat Ngudi Kapinteran
Authors: Hermawan Yudan , Suryono Yoyon 
Published: March 2017

Tujuan penelitian untuk mengetahui: (1) tahapan, (2) bentuk, (3) faktor-faktor yang mempengaruhi, dan (4) strategi pengembangan partisipasi masyarakat dalam penyelenggaraan program-program PKBM Ngudi Kapinteran, Semanu, Gunungkidul. Penelitian kualitatif dengan metode studi kasus. Hasil penelitian yaitu (1) Tahapan partisipasi masyarakat dimulai dari proses perencanaan, pelaksanaan, evaluasi serta pemanfaatan hasil. (2) Bentuk partisipasi masyarakat terbagi dalam dua bentuk meliputi; (a) fisik yaitu material dan tenaga, dan (b) non fisik yaitu ide. (3) Faktor-faktor yang mempengaruhi partisipasi masyarakat yaitu faktor pendukung yang berupa budaya dan kebermanfaatan program sedangkan faktor penghambatnya adalah tingkat pendidikan dan jenis pekerjaan. (4) Strategi pengembangan partisipasi masyarakat yaitu dengan komunikasi, keterlibatan masyarakat dan pemberdayaan komunitas.Kata Kunci: pemberdayaan, program, partisipasi masyarakat, PKBM Community Participation in the Implementation of Programs of Community Learning Center (PKBM) Ngudi KapinteranAbstractThe aim of research to determine: (1) the step, (2) forms, (3) affecting factors, and (4) development of community participation in implementing the programs of PKBM Ngudi Kapinteran, Semanu, Gunungkidul. The qualitative research with case study method. Results of the study are: (1) the steps of public participation are started from the process of plan, implementation, evaluation and utilization of results. (2) the form of community participation in divided into two forms, (a) physical wich are idea and thougt, and (b) the non-physical form of idea. (3) factors affecting public participation namely the supporting factors are of cultural and advantage of program and limiting factors are the level of education and type of work. (4) the development strategis are through communication, community involvement and community empowerment.Keywords: empowerment, program, community participation, community learning center.
Efektivitas komunikasi orang tua dan pendidik terhadap keberhasilan program kelompok bermain
Authors: Astuti Febru Puji 
Published: March 2017

Penelitian ini bertujuan untuk mengetahui keefektifan komunikasi orang tua dan pendidik yang dilakukan di lembaga PAUD Happy Bear, Magelang. Penelitian ini merupakan studi kasus, menggunakan metode kualitatif. Unit penelitian meliputi pendidik, orang tua, dan pengelola. Data dikumpulkan melalui teknik pengamatan, wawancara, dan dokumentasi. Teknik analisis data dilakukan dengan tiga kegiatan utama, yakni: reduksi data, penyajian data, dan penarikan kesimpulan. Keabsahan data dilakukan dengan kredibilitas melalui pemeriksaan ketekunan pengamatan, triangulasi sumber dan triangulasi metode. Hasil penelitian menunjukkan bahwa proses komunikasi antara orang tua dan pendidik di PAUD Happy Bear lebih cenderung menggunakan pola keterbukaan yang memungkinkan seluruh pihak yang berkepentingan untuk saling bertukar informasi. Kegiatan program dilaksanakan dan dikomunikasikan melalui pertemuan yang melibatkan orang tua. Efektivitas komunikasi yang ada ditunjukan adanya perubahan yang makin baik dalam ketercapaian dan keberhasilan program kelompok bermain.Kata Kunci: efektivitas, komunikasi, keberhasilan program The effectiveness of parents and teachers communication to the success of playgroup program AbstractThis study was aimed to investigate the communication prosess and the effectiveness of communication between parents and teachers at PAUD Happy Bear, Magelang. This reseach was a case study, it used qualitative method. The reseach units included teachers, parents, and organizers. Data were collected using observation, interviews, and documentations. The data analysis technique is done with three main activities, namely data reduction, data display, and inference making. The data trustworthiness was assessed by the credibility technique through careful observation, source triangulation, and technique triangulation. The results show that the process of communication between parents and educators in PAUD Happy Bear is more likely used the pattern of openness that allows all interested parties to exchange information. Program activities is implemented and communicated through meetings and involving parents. The effectiveness of existing communication patterns indicate changes that are getting better in the achievement and success of the playgroup program.Keywords: effectiveness, communications, program success