bluuebunny/crossref_metadata_2025_split huggingface dataset:
Child maltreatment elevated the risk of late-life chronic pain: a biopsychosocial framework from the UK Biobank cohort
Authors: Zhao Wenhui , Lu Xuejing , Tu Yiheng 
Published: October 2024

Abstract
Understanding the development of chronic pain (CP) is challenging due to its multifactorial etiology. Child maltreatment (CM), encompassing various types of neglect and abuse affecting more than one-third of the population, is a critical aspect of early-life adversity with long-lasting impacts. It is increasingly recognized for its role in altering biopsychosocial processes, potentially increasing vulnerability to CP. However, the exact path connecting CM to CP is not fully elucidated, primarily attributable to limitations in prior research, including insufficient sample sizes, inadequate consideration of comprehensive mediative variables, and a lack of longitudinal data. To address these gaps, our study utilizes a large-scale dataset (n = 150,989) comprising both cross-sectional and longitudinal data, along with an extensive range of biopsychosocial variables. Our findings reveal that all types of CMs, except physical neglect, significantly increase the risk of CP, and all types of CPs, except headache, were affected by CM. Furthermore, we demonstrate that individuals with CM histories are more predisposed to comorbid CP conditions. Importantly, biopsychosocial factors are found to explain over 60% of the association between CM and CP, with psychological factors playing a key role. This study not only characterizes the relationship between CM and CP but also underscores the influence of psychosocial elements in this dynamic interplay. These findings offer important insights into the long-term impacts of CM and provide a foundation for developing targeted therapeutic and preventive strategies for CP.
Slack potassium channels in spinal dorsal horn neurons control neuropathic pain and acute itch
Authors: Zhou Fangyuan , Engel Patrick , Ruth Peter , Lukowski Robert , Schmidtko Achim , Lu Ruirui 
Published: October 2024

Abstract
The sodium-activated potassium channel Slack (KNa1.1, Kcnt1) plays a critical role in tuning neuronal excitability. Previous studies have revealed that Slack is expressed in neurons of the superficial dorsal horn of the spinal cord. However, the precise role of Slack in spinal dorsal horn neurons is unclear. In this study, we used mice in which Slack is conditionally ablated in spinal dorsal horn neurons (Lbx1-Slack−/− mice) and analyzed their behaviors in various models of pain and itch. Lbx1-Slack−/− mice exhibited increased neuropathic pain behavior after peripheral nerve injury but normal responses in a model of inflammatory pain. Unexpectedly, Lbx1-Slack−/− mice demonstrated increased scratching after intradermal injection of chloroquine, LY344864, and histamine. Moreover, neuromedin B receptors are coexpressed with Slack in the dorsal horn, and scratching after intrathecal delivery of neuromedin B was increased in Lbx1-Slack−/− mice. Our study provides in vivo evidence that Slack expressed in spinal dorsal horn neurons inhibits nerve injury–induced allodynia and acute itch induced by various pruritogens.
Tracheal transplantation: lessons learned that may apply to lung transplantation
Authors: Genden Eric M. , Chen Ya-Wen 
Published: October 2024

Purpose of review
The purpose of this review is to explore the lessons learned from experimental and human tracheal transplantation to determine if this information may be applied to lung transplantation.

Recent findings
Experimental work in animal models and the recent human tracheal transplantation suggests that a robust tracheal vascular supply prevents anastomotic complications. Further, this work demonstrates that tracheal allografts undergo a progressive chimerism as recipient epithelium repopulates the allograft. In contrast to most vascularized composite allografts such as hand and face transplantation that experience high rates of rejection, the tracheal allograft did not demonstrate rejection. This may suggest that tissue chimerism plays a role in evading immune-mediated allograft rejection.

Summary
While anastomotic complications and chronic allograft rejection are the most common complications related to lung transplantation, the findings associated with tracheal transplantation may have implications for both reducing complications associated with lung transplantation.
Advancements in Imaging for the Diagnosis of Wake-up Stroke
Authors: Li Yang , Ma Chun-Hui 
Published: October 2024

Background:
The concept of wake-up stroke (WUS) as a distinct subtype of acute ischaemic stroke, characterized by an uncertain onset time, traditionally resulted in the exclusion of patients from intravenous thrombolysis treatment.

Review Summary:
Advancements in neuroimaging have prompted a shift in the approach to intravenous thrombolysis treatment, moving away from a strict focus on the onset time window toward consideration of the tissue time window. This paradigm shift has expanded the opportunity for a larger cohort of patients with WUS to receive timely and effective treatment, ultimately leading to improved prognosis.

Conclusions:
This study reviews the WUS pathogenesis and the progress of various imaging diagnostic techniques to clarify the WUS onset time and select the optimal treatment plan.
Bone density changes in young women in Uganda using tenofovir-based HIV preexposure prophylaxis and depot medroxyprogesterone acetate contraception
Authors: Heffron Renee , Muwonge Timothy R. , Thomas Katherine K. , Zewdie Kidist , Ssebuliba Timothy , Stein Gabrielle , Morrison Susan , Badaru Josephine , Nakyanzi Agnes , Bambia Felix , Mugwanya Kenneth , Wyatt Christina , Matovu Flavia , Yin Michael T. , Mujugira Andrew 
Published: October 2024

Background:
Injectable depot medroxyprogesterone acetate (DMPA) is the most common contraceptive choice among young women in Uganda, where HIV burden is high and HIV preexposure prophylaxis (PrEP) may be offered. For young women who choose to use both agents concurrently, it is unknown whether they will experience declines in bone mineral density (BMD) beyond those elicited by either product singly.

Methods:
From 2018 to 2022, we conducted a 2-year prospective study with women ages 16–25 years in Kampala, Uganda desiring pregnancy and HIV prevention. Women were provided condoms, injectable DMPA, and/or FTC/TDF, according to their choices and underwent annual dual X-ray absorptiometry (DXA) scans. We used tenofovir-diphosphate (TFV-DP) quantification in dried blood spots and DMPA injection dates to classify exposure. Linear regression models estimated the difference in percent BMD change from baseline to month 12 for women using FTC/TDF and DMPA versus women using neither product.

Results:
Of 499 enrolled women, discontinuation and re-starting of contraception and PrEP was common. Women consistently using neither product (n = 39) experienced BMD increases. Women with consistent use of both products during 1 year (n = 22) experienced an average BMD loss of 1.04% at lumbar spine and hip and 1.77% at femoral neck. These losses were different relative to women who used neither agent: lumbar spine −3.35% (95% CI −5.13 to −1.56%, P = 0.001), total hip −2.24% (95% CI −3.87 to −0.60%, P = 0.009), and femoral neck −1.71% (95% CI −3.73 to 0.31%, P = 0.102).

Conclusion:
We observed a trend for women with concurrent DMPA and FTC/TDF PrEP use to have 1–3% lower BMD than unexposed women after 12 months.
Flower/FLWR-1 regulates neuronal activityviathe plasma membrane Ca2+-ATPase to promote recycling of synaptic vesicles
Authors: Seidenthal Marius , Redzovic Jasmina , Liewald Jana F. , Rentsch Dennis , Shapiguzov Stepan , Schuh Noah , Rosenkranz Nils , Eimer Stefan , Gottschalk Alexander 
Published: October 2024

AbstractThe Flower protein was suggested to couple the fusion of synaptic vesicles (SVs) to their recycling in different model organisms. It is supposed to trigger activity-dependent bulk endocytosis by conducting Ca2+at endocytic sites. However, this mode of action is debated. Here, we investigated the role of theCaenorhabditis eleganshomolog FLWR-1 in neurotransmission. Our results confirm that FLWR-1 facilitates the recycling of SVs at the neuromuscular junction (NMJ). Ultrastructural analysis of synaptic boutons after hyperstimulation revealed an accumulation of large endocytic structures inflwr-1mutants. These findings do not support a role of FLWR-1 in the formation of bulk endosomes but rather a function in their breakdown. Unexpectedly, loss of FLWR-1 led to increased neuronal Ca2+levels in axon terminals during stimulation, particularly in GABAergic motor neurons, causing excitation-inhibition imbalance. We found that this increased NMJ transmission might be caused by deregulation of MCA-3, the nematode orthologue of the plasma membrane Ca2+ATPase (PMCA).In vivomolecular interactions indicated that FLWR-1 may be a positive regulator of the PMCA and might influence its recycling through modification of plasma membrane levels of PI(4,5)P2.
Consumer privacy decision-making in digital era: an integrative review and taxonomy
Authors: Sun Zhuo , Pan Gaofeng , Yang Ruixian , Zang Guoquan , Zhou Jinghong 
Published: October 2024

PurposeIn the digital age, personalized services and accurate recommendations enhance the customer experience and streamline shopping. However, increasing concerns about personal privacy have led to resistance from consumers, necessitating a balance between providing high-quality online services and safeguarding personal data. The aim of this paper is to offer a comprehensive review of the fragmented literature on consumer privacy decision-making and to identify key issues worth exploring in future research.Design/methodology/approachAlthough previous studies have analyzed the antecedents and outcomes of privacy decisions, they have often been conducted in a fragmented manner. There remains a lack of a holistic understanding of the factors influencing privacy decisions, including their boundaries. Therefore, we build on the Theory of Planned Behavior to combine consumer privacy decision-making with a graphically conceptual framework used in a similar scoping methodology. We attempt to dissect the antecedent, moderator and outcome variables that influence consumer privacy decision-making, ultimately providing a comprehensive framework for understanding these dynamics.FindingsBased on the Theory of Planned Behavior, we analyze the entire process of consumer privacy decision-making in terms of antecedent, moderating and outcome variables. The results indicate that consumer privacy decision-making is not an isolated behavior or a single choice but a complex, multi-level dynamic process. The factors influencing consumer privacy decisions primarily encompass five aspects: individual characteristics, information, organization, platform and interaction management, leading to various outcomes in both behavioral and perceptual dimensions. Furthermore, the process is constrained by multiple moderating variables, such as information sensitivity, platform knowledge and prior experience.Originality/valueWe build on the Theory of Planned Behavior to combine consumer privacy decision-making with a graphically conceptual framework used in a similar scoping methodology. We dissect the antecedent, moderator and outcome variables that influence consumer privacy decision-making, aiming to provide a comprehensive framework for understanding these processes.
Artificial intelligence in corporate communications: determinants of acceptance and transformative processes
Authors: Kelm Karolin , Johann Michael 
Published: October 2024

PurposeThis study investigates the determinants of artificial intelligence (AI) acceptance in and AI-driven transformations of corporate communications. From a technology adoption perspective, the study explores the dual influence of individual and organizational factors on AI acceptance.Design/methodology/approachEmploying a qualitative research design, this study conducted semi-structured interviews with 19 AI experts in large-scale companies in Germany.FindingsThe study reveals micro-level determinants of AI acceptance related to AI’s perceived usefulness and ease of use. It also identifies macro-level determinants, including organizational awareness and frameworks. Corporate communications is expected to gain relevance due to the organizational integration of AI.Research limitations/implicationsThe proposed model integrates crucial factors influencing AI adoption and offers a starting point for quantitative validation. The study serves as a benchmark for future research, particularly given its timing right before the extensive adoption of ChatGPT.Practical implicationsOrganizations are encouraged to develop strategies that enhance both individual and organizational AI readiness. By reflecting both micro- and macro-level determinants of AI acceptance, a more holistic understanding of effective change management initiatives related to AI integration can be fostered.Originality/valueBy proposing an extension to the technology acceptance model, which incorporates both micro- and meso-level determinants, this study provides a novel framework for holistically understanding AI acceptance in corporate communications.
Digitalization of construction-phase information management by project owners: qualitative analysis of potential benefits and probable factors
Authors: Jahanger Qais K. 
Published: October 2024

PurposeThe US construction industry has been relatively slow to employ digital information technologies. The lack of adoption by project owners is a result of them not having a solid understanding of probable factors (PFs) that could influence the implementation of such systems and potential benefits (PBs) that can serve as key motivators and an assessment instrument. Thus, this article aims to study PBs of digital construction-phase information management (DCIM) systems for project owners and PFs that could influence the implementation of such systems by project owners.Design/methodology/approachQualitative data collection and analysis methods were followed to conduct the research. The qualitative data (information) regarding PBs and PFs were collected using a survey to subject matter experts and the content analysis method was used to analyze the data.FindingsFindings show that almost all the qualitative data regarding PBs of DCIM systems are positive, and these data support 10 of 18 PBs with which they were compared. The qualitative data that is negative does not support one PB. Findings also show that all the qualitative data regarding the PFs are confirmatory, and these data support 14 of 28 PFs with which they were compared. The most supported PB is improvement in the efficiency of documentation within the organization and the most supported PF is upper management support.Originality/valueThe primary contribution of this research is in increasing project owners’ understanding of PBs of DCIM systems and PFs that could influence the implementation of such systems.
Understanding human–technology interaction: evolving boundaries
Authors: Magliocca Pierpaolo , Canestrino Rossella , Carayannis Elias G. , Gagliardi Anna Roberta 
Published: October 2024

PurposeThis paper explores the intricate evolution of human–machine interaction within the framework of Society 5.0, highlighting how technological advancements influence human behavior and societal progress.Design/methodology/approachA multidimensional framework is developed through a qualitative approach to analyze the evolution of human–technology interaction. This innovative conceptual model provides a comprehensive understanding of these dynamics.FindingsThe proposed model unveils a significant shift from perceiving technology as a mere tool to acknowledging its profound influence on daily routines and potential enhancements. This revelation underscores the critical role of human-centric strategies, enlightening us about the evolving nature of technology.Research limitations/implicationsThe study synthesizes existing research to present a comprehensive framework for understanding human–machine interaction, providing insights that can inform future research and theory development.Practical implicationsThis study equips policymakers, researchers and practitioners with actionable strategies to enhance technology use. By incorporating human-centric approaches, addressing issues such as technostress and promoting effective digital knowledge management, this research empowers the audience with practical solutions.Social implicationsThe paper underscores the broader impact of technology on societal progress. It emphasizes the importance of incorporating human-centric strategies in technology implementation to promote fairness, inclusivity and overall societal well-being.Originality/valueThis paper introduces an innovative conceptual model based on a multidimensional framework to analyze the complex evolution of human–technology interaction. It enriches the ongoing debate by highlighting the nuanced relationship between humans and technology, addressing significant gaps in existing literature and offering an original interpretative perspective.
Does total quality management mediate the relationship between Industry 4.0 and business sustainability in private hospitals?
Authors: Zaid Ahmed Adnan , Othman Mohammed , Qubbaj Ihab Sameer , Asaad Ahmed Riyad 
Published: October 2024

PurposeThe paper aims to study the influence of Industry 4.0 technologies on the business sustainability of private hospitals by focusing on the mediating role of total quality management practices in private hospitals in the West Bank.Design/methodology/approachData from the top and middle managers of private hospitals in the West Bank regions of Palestine were collected through a questionnaire assessed for validity and reliability. Furthermore, we used the structural equation modelling technique of partial least squares for the data analysis.FindingsThe findings confirm that Industry 4.0 technologies do not affect business sustainability. The findings also emphasise the association between Industry 4.0 technologies and total quality management philosophy, and total quality management completely mediates the relationship between Industry 4.0 and business sustainability.Practical implicationsThis study provides practical implications for achieving the hospital sector's sustainability by merging Industry 4.0 technologies with total quality management practices, which provides valuable insights into the hospital's policies and practices and individuals vital to data exchange and policy enforcement within the sustainability of organisations.Originality/valueThis study is one of the first to investigate the combined effects of Industry 4.0 technologies, total quality management and business sustainability in the healthcare industry following the COVID-19 outbreak. This research is one of few empirical works exploring the interface between Industry 4.0 technologies and total quality management in developing countries, specifically Palestine.
Peer mentoring and identity transformation in a women’s prison
Authors: Smith April 
Published: October 2024

Purpose
This study examined the impact of peer mentoring on identity transformation amongst women in prison, exploring how peer mentoring roles develop non-offender identities, contributing to the desistance process.

Design/methodology/approach
A qualitative, interpretative approach was adopted. The research was undertaken at a female prison in England and Wales. Data was collected through semi-structured interviews with peer mentors, mentees, project workers and prison officers, alongside focus groups. Thematic analysis was used to analyse the findings.

Findings
Being a peer mentor contributes positively to identity transformation for women in prison, fostering a legitimate, non-offender identity critical to the desistance process. Mentors view their role as a desistance signal through their interactions with prison staff. However, it can lead to role conflict and tension with other women in prison and prison staff.

Research limitations/implications
Future studies should consider longitudinal approaches to capture the long-term effects of peer mentoring upon desistance.

Practical implications
Recommendations include leveraging peer mentoring as a rehabilitative intervention, providing ongoing support for mentors and educating prison staff on programme benefits to foster a supportive environment.

Social implications
Enhancing peer mentoring programmes can improve the well-being of women in prison and support their reintegration into society.

Originality/value
This study examined identity transformation in female peer mentors in prison through the lens of social identity and group membership. To the author’s knowledge, no previous studies have focused centrally on identity or applied social identity theory to explore the psychological mechanisms behind these transformations.
Does disclosing commercial intention benefit brands? Mediating role of perceived manipulative intent and perceived authenticity in influencer hidden advertising
Authors: Shen Pengyi , Nie Xuan , Tong Congcong 
Published: October 2024

PurposeDespite sponsorship disclosure regulations, many influencers circumvent regulations by posting hidden advertising in covert formats. However, the impact of influencer hidden advertising sponsorship disclosure (IHASD) on brand attitudes is complex and contradictory. To understand the influence mechanism clearly, we introduced the operational transparency framework and investigated the mediating effects of perceived manipulative intent and perceived authenticity as well as the relationship between them. The conditions under which the mediation effect occurs were also analyzed.Design/methodology/approachThe authors conducted three experimental studies. Studies 1 and 2 examined the influence mechanism of sponsorship disclosure (present vs absent) and sponsorship disclosure prominence (explicit vs implicit) of influencer hidden advertising on brand attitudes (i.e. the mediating effect of perceived manipulative intent and perceived authenticity). Study 3 explored the moderating effect of consumers’ thinking styles.FindingsThe results revealed that sponsorship disclosure and sponsorship disclosure prominence of influencer hidden advertising weakened brand attitudes through perceived manipulative intent while enhancing brand attitudes through perceived authenticity. Perceived authenticity and perceived manipulative intent played a bidirectional chain mediating role. When consumers’ thinking style was experiential, the negative mediating effect of perceived manipulative intent was alleviated and the positive mediating effect of perceived authenticity was enhanced; this effect, though, was the opposite when consumers’ thinking style was rational.Originality/valueThis research contributes to influencer sponsorship disclosure literature through providing an enhanced comprehensive, in-depth theoretical explanation of the competing mechanisms of sponsorship disclosure effects.