bluuebunny/crossref_metadata_2025_split huggingface dataset:
Caracterización morfológica y molecular de cepas nativas de Trichoderma y su potencial de biocontrol sobre Phytophthora infestans
Authors: García-Núñez Hilda Guadalupe , Martínez-Campos Ángel Roberto , Hermosa-Prieto María Rosa , Monte-Vázquez Enrique , Aguilar-Ortigoza Carlos Jorge , González-Esquivel Carlos Ernesto 
Published: April 2017

El presente trabajo muestra la caracterización morfológica y molecular de 10 cepas nativas de <em>Trichoderma</em> (TL2, TL4, TL5, TL6, TX7, TX8, TT6, TF8, TF10 y TJ6) y su relación filogenética, así como su capacidad de biocontrol contra <em>Phytophthora infestans</em>. Los resultados de la caracterización molecular al amplificar la región ITS1-ITS4 del ADN ribosómico nuclear y un fragmento del gen <em>tef1α</em> mostraron que de las 10 cepas, seis corresponden a <em>Trichoderma asperellum</em> (TL2, TL4, TX7, TX8, TT6 y TF8) y cuatro a <em>T. harzianum</em>/<em>Hypocrea lixii</em> (TL5, TL6, TF10 y TJ6). El análisis filogenético por máxima parsimonia demostró que existe una estrecha relación entre las cepas de estos dos grupos. Las pruebas <em>in vitro</em> de biocontrol entre el antagonista y el patógeno indicaron diferencias significativas (p&lt;0.05). La cepa TX8 registró el mayor porcentaje (98 %) de inhibición, mientras que TL4 fue la de menor porcentaje (49 %). Las cuatro cepas de <em>H. lixii</em> (TL5, TL6, TF10 y TJ6) presentaron capacidad de inhibición media (55-66 %).
Phytophthora hydropathica y Phytophthora drechsleri aisladas de canales de irrigación del Valle de Culiacán
Authors: Álvarez-Rodríguez Brando , García-Estrada Raymundo Saúl , Valdez-Torres José Benigno , León-Félix Josefina , Allende-Molar Raúl , Fernández-Pavía Sylvia Patricia 
Published: April 2017

<p><span>En México, no existen reportes de la presencia de especies de <em>Phytophthora </em>en aguas su­perficiales, de ahí la importancia de determinarlas ya que representan un riesgo para la agricultura del país. En enero de 2015, se muestrearon 25 canales de irrigación en el Valle de Culiacán con el objetivo de identificar las especies de <em>Phytophthora </em>presen­tes. Los aislamientos fueron obtenidos con trampas que consistieron en hojas de azalea y frutos de pera. Se obtuvieron 29 aislamientos de <em>Phytophthora</em>, los cuales fueron identificados con base en caracterís­ticas morfológicas y en secuencias de ADNr de los espaciadores internos transcritos (ITS) y del factor de elongación 1-α (TEF-1α). Se realizaron pruebas de patogenicidad en hojas de tomate y chile, de­bido a que son cultivos importantes en la región y son irrigados con agua de los canales muestrea­dos. Se identificaron 2 especies: <em>P. hydropathica </em>y <em>P. drechsleri</em>. Los aislamientos de <em>P. hydropathica </em>ocasionaron lesiones necróticas en hojas de toma­te y de chile; mientras que los aislamientos de <em>P. drechsleri </em>solamente causaron lesiones en hojas de tomate. De acuerdo con nuestro conocimiento, este es el primer reporte de <em>P. hydropathica </em>en México. </span></p><p class="Default"> </p><p><span><br /></span></p>
Influence of Apico‐Coronal Implant Placement on Post‐Surgical Crestal Bone Loss in Humans
Authors: Ercoli Carlo , Jammal Georges , Buyers Madeline , Tsigarida Alexandra Athanasiou , Chochlidakis Konstantinos Michail , Feng Changyong , Caton Jack 
Published: April 2017

Background: Contradictory results exist regarding influence of apico‐coronal implant placement on crestal bone levels.Methods: Complete charts of patients ≥18 years old with one or more dental implants were included. Demographic, medical, surgical, and prosthetic information was recorded. Implant bone levels were evaluated at initial placement, implant uncovery, prosthetic delivery, and 3 to 6, 7 to 11, and 12 to 18 months post‐implant placement.Results: Charts of 55 patients and 134 implants were included. At baseline, 19.5%, 67.3%, and 13.3% of implants were recorded as equicrestal, subcrestal, and supracrestal, respectively, on their mesial aspect, and 32.1%, 50.0%, and 17.9% on their distal aspect, respectively. At time of prosthetic delivery, mesial aspect implant position was equicrestal in 35.4%, subcrestal in 17.7%, and supracrestal in 46.9% of cases, whereas on their distal aspects, the same categorical positions were found in 28.4%, 21.1%, and 50.5% of implants. For the mesial aspect of the implant, 3‐ to 6‐, 7‐ to 11‐, and 12‐ to 18‐month intervals, and for the distal aspect of the implant, 7‐ to 11‐ and 12‐ to 18‐month intervals, along with diabetes (for both mesial and distal), were associated with a statistically more apical position of the bone compared with baseline. Although the odds ratio of a subcrestal implant position at follow‐up times was statistically greater for implants located subcrestally at surgery, linear measures of differential crestal bone loss (CBL) as a function of the categorical initial placement of the implant (supracrestal, equicrestal, subcrestal) at 3‐ to 6‐, 7‐ to 11‐, and 12‐ to 18‐month time points generally showed no significant differences among groups.Conclusion: A subcrestal position of the implant at time of surgery leads to reduced odds of having implant threads exposed; however, it is associated with similar linear CBL compared with an equicrestal or supracrestal surgical position.
El niño santo en el orfismo. O de Eros y el significado oculto de erikepaios
Authors: Martínez Villarroya Javier 
Published: April 2017

En 2008 publicamos una tesis en la que aplicábamos el método de clasificación de símbolos propuesto por Gilbert Durand al corpus órfico. Desde la antropología, la hermenéutica, el psicoanálisis y la fenomenología de las religiones, abordamos la barahúnda de símbolos y obtuvimos resultados interesantes. Según el mencionado “método de convergencia”, las cosmovisiones humanas son tripartitas: los símbolos de un pueblo tienen que ver con (a) el instinto de “caminar erecto”, (b) el de nutrirse (mamar) o (c) el reproducirse (el sexo). Platón, en el Timeo, explica también la estructura del mundo a partir de tres símbolos, a los que designa, entre otras formas, como padre, madre e hijo. En esta investigación nos embarcamos en el análisis de la palabra erikepaios. Partiendo de los estudios más recientes de Alberto Bernabé y sus colaboradores, y retomando ciertas interpretaciones de la filosofía griega (Marcel Detienne, Peter Kingsley, Walter Burkert, etcétera), concluimos que, efectivamente, en los textos órficos el protagonista es el muerto, pero lo es, sin embargo, por estar vivo: por ser el renacido, el iniciado, el niño santo.
Influence of ghrelin on rat pituitary GH3 cell line proliferation
Authors: Chmielewska Małgorzata , Andrusiewicz Mirosław , Żbikowska Aleksandra , Kątniak Katarzyna , Sadowska Agnieszka , Arasimowicz‑Banaszak Grażyna , Graczyk Sławomir , Waśko Ryszard , Kotwicka Malgorzata 
Published: April 2017

Introduction. Human ghrelin is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHSR1a). It is suggested that ghrelin is involved in pituitary adenomas pathogenesis. There are inconsistent data regarding the effect of ghrelin on cell proliferation. In this study the outcome of ghrelin in the rat pituitary adenoma GH3 cell line on morphology and proliferation ratio was evaluated. The ghrelin receptor (Ghsr) mRNA expression in GH3 cell line was established as well, because it was found that heterogeneous expression pattern characterized physiological and pathological conditions of tissues of different origin.Material and Methods. Suitable experimental model pituitary tumor (rat GH3 cell line) was stimulated with ghrelin in the final concentrations 10–12 M, 10–9 M and 10–6 M. Reverse transcription followed by real time polymerase chain reaction was used for ghrelin receptor gene transcript detection. The morphology as well as cell cycle of those cells were analyzed using Axio Vert.A1 Microscope (Zeiss) and BD FACSCalibur™ flow cytometer (Beckton Dickinson), respectively. The percentages of cells in the G0/G1, S, G2/M cycle phases were evaluated using the ModFit™ software (Verity Software, Inc., USA). Results. Ghsr mRNA presence was confirmed in GH3 cells. Ghrelin did not affect conspicuously GH3 cells morphology, however the ghrelin‑induced proliferation index increase was caused by both decline of G0/G1 phases cells count and increase those being in S+G2/M (p < 0.05). Conclusions. In conclusion, this study indicates that ghrelin stimulates GH3 cells proliferation and may play role in pituitary tumorigenesis via an autocrine/paracrine pathway.
In vitro biofilm formation and antibiotic susceptibility of Pseudomonas aeruginosa isolated from airways of patients with cystic fibrosis
Authors: Długaszewska Jolanta , Antczak Marta , Kaczmarek Izabella , Jankowiak Renata , Buszkiewicz Malgorzata , Herkowiak Magdalena , Michalak Klaudia , Kukuła Helena , Ratajczak Magdalena 
Published: April 2017

Background: Pseudomonas aeruginosa is the predominant cause of airway infections in patients with cystic fibrosis (CF) as a result of its ability to form biofilm. Resistance to antimicrobial agents is the most important feature of biofilm infection. The aim of this study was to evaluate biofilm formation and to compare antibiotic susceptibility of P. aeruginosa living in two modes of growth: planktonic and biofilm, isolated from respiratory tract of CF patients. Methods: Biofilm formation and biofilm susceptibility to antibiotics were determined using modified microtitere plate method. For susceptibility testing of planktonic culture to antibiotics serial microdilution broth method were used.Results: More than 95% of isolates were capable to form biofilm. Isolates grown as biofilms were more resistant to tested antibiotics compared to those grown planktonically. Ciprofloxacin showed the highest activity against P. aeruginosa biofilm. In contrast, no bacteriostatic activity was obtain for the highest concentration of piperacillin tested against most of P. aeruginosa strains growing in a biofilm (BIC > 4096 mg/L).Conclusions: Our study indicates the need to develop a standardized susceptibility testing method for biofilm mode of growth of pathogens. It appears that it is appropriate to introduce a biofilm susceptibility testing to routinely performed tests, as the effect of antibiotics on biofilm eradication may be variable and unpredictable.
Lower diastolic blood pressure in healthy subjects with vitamin K deficiency: a preliminary cross-sectional study
Authors: Nowak Jan Krzysztof , Wykrętowicz Andrzej , Krzyżanowska Patrycja , Górna Agnieszka , Tobolski Jarosław , Mądry Edyta , Walkowiak Jarosław 
Published: April 2017

Introduction. There is a growing body of evidence for the role of vitamin K in cardiovascular health. As a cofactor of carboxylation of the matrix Gla protein it prevents arterial calcification. However, the data on the relationship between vitamin K status and the blood pressure are scarce, and particularly so in persons without the burden of cardiovascular risk factors. Material and Methods. We performed a pilot cross‑sectional study, in which we hypothesized that vitamin K deficiency is associated with a higher blood pressure in young, healthy people. The concentration of protein induced by vitamin K absence‑II (PIVKA‑II) larger than 2 ng/mL was chosen as a proxy for vitamin K deficiency; it was assessed in serum using ELISA. Blood pressure was measured using a validated, automated oscillometric monitor in triplicate.Results. Twenty‑three healthy subjects were enrolled (16 female; mean age 21.3 ± 1.6 years; body mass index 20.6 ± 2.4 kg/m2). The diastolic blood pressure (DBP) was lower in vitamin K‑deficient subjects (58 ± 9 vs. 67 ± 5 mmHg, p = 0.01). The mean arterial blood pressure also differed (75 ± 9 vs. 83 ± 6, p = 0.02). PIVKA‑II levels correlated with DBP only (Pearson’s R = -0.41, p < 0.05; Spearman’s ρ ns.). Stepwise regression identified PIVKA‑II concentrations as the only independent parameter associated with DBP (adjusted R2 = 13.1%; PIVKA‑II: β = -0.41; 95%CI -1.87-(-0.00098), t = -2.08, p < 0.05).Conclusions. The relationship between vitamin K deficiency and low DBP in young adults should be investigated further.
Casing Vapor Recovery Optimization and Heavy Oil Maximization through Seasonal Effects
Authors: Gentile Lauren , Larner Erin 
Published: April 2017

Abstract
In this study we suggest a procedure to optimize Casing Vapor Recovery (CVR) systems during seasonal temperature changes. Previous seasonal effects caused several operational upsets. Obtaining physical measurements is costly, and in some cases, not operationally possible. This process is aimed at lowering CVR pressures instantaneously and aiding thermal recovery field operations while maximizing heavy oil production.
Routine CVR sweeps are performed based on business rules before high temperature seasons. Not all wells are fitted with the equipment for such testing. Furthermore, a small sample of wells had casing chokes installed to manage produced steam via pressure drop into the CVR system. For the rest of the operational wells in the field, predictive analytics developed a relationship between produced steam volumes and surface measurements to create a diagnostic tool for managing CVR systems. Measurements of produced steam from individual wells were compared to the empirical equation for validation. Once validated, a forced ranked produced steam to oil ratio (PSOR) was calculated and a report generated.
Historically, spring and summer seasons see decreased CVR system efficiency due to increased ambient air temperature (Figure 3) resulting in less cooling efficiency prior to compression. In order to eliminate operational issues and equipment damage, total gas flow into the CVR system must be decreased. Prior to this project, operations had experienced several process upsets due to the low equipment efficiency. Trouble shooting upsets was difficult and often resulted in production loss. After implementing the PSOR ranked list during ambient air temperature shifts, operations was able to manage casing gas volumes and pressures with minimal impact to production. This process, in conjunction with robust system surveillance, minimizes field upsets and oil production impact during periods of significant ambient air temperature shifts.
The resulting project analytics provide real time PSOR values versus the single point in time physical measurements used in the past, which were ambient air temperature and system upset sensitive.
Additionally, the new CVR optimization through seasonal effect method has changed our operational strategy from an individual well focus to a system wide focus. This change in strategy has increased oil production in summer months relative to the old strategy.
Rapid S-Curve Update Using Ensemble Variance Analysis with Model Validation
Authors: He Jincong , Tanaka Shusei , Wen Xian-Huan , Kamath Jairam 
Published: April 2017

Abstract
Production forecasting for oil and gas reservoir is highly uncertain due to various subsurface uncertainties. Rapid interpretation of measurement data and update of the probabilistic forecast results are crucial for reducing uncertainty and devising high-side capture or low-side mitigation plans. Traditional history-matching-forecasting workflow requires a long life-cycle and a large number of simulations. In this work, we propose a novel method to rapidly update the prediction S-curves given early production data without performing additional simulations or model updates after the data come in.
The proposed method consists of several steps. Before the data come in, we perform an ensemble of simulations to calculate the correlation between the measurement data (e.g. BHP) and the business objective (e.g. EUR). After the data come in, we first perform model validation step based on Mahalanobis distance and statistical testing to determine the validity of the model given observation data. If the model passed the validation test, principal component analysis (PCA) will be applied to precondition the observation data to detect and modify the response which cannot be explained by simulation responses. Finally, an analytical formula based on multi-Gaussian assumption will be used to estimate the posterior S-curve of the business objective.
The approach has been successfully applied in a Brugge waterflood benchmark study, in which the first 2 years of production data (rate and BHP) were used to update the S-curve of the estimated ultimate recovery. Through the study we observed several key advantages of the proposed method. Compared with traditional history matching methods, our proposed method focuses on the data-objective function relationship and thus circumvents the need to update the model parameters and states. The ensemble of simulations can be pre-computed and no additional simulation is needed after data arrives. In addition, our proposed method is insensitive to the number of parameters, and does not require the use of a numerical proxy for simulations, which is normally needed with traditional sampling- based methods.
As far as we know, the proposed workflow, including the model validation and the de-noising techniques, is novel. The proposed workflow is also general enough to be used in other model-based data interpretation applications.
Waterflood Planning and Piloting in a Tight Sandstone with Stimulated Wells: Buena Vista Nose Case Study
Authors: Omelchenko Roman , Wang Guanglan , Klepacki Doug , Cooper Marc 
Published: April 2017

Abstract
The paper covers green field development in a low-permeability reservoir, where water injection is under consideration. To maximize economic value, accurate well placement and key data gathering during delineation and appraisal will allow for early cash flow generation and preservation of ultimate waterflood reserves by operating above the bubble point pressure. Conversely, implementation of pressure support schemes absent information on reservoir connectivity, effective rock/fluid properties, and aquifer strength can result in an over-capitalization of investment via unnecessary expenditures. Implementation of a waterflood in a low matrix permeability system requiring well stimulation to achieve economic oil rates requires more sophisticated reservoir understanding compared to reservoirs with more favorable rock/fluid properties. A properly sequenced multi-disciplinary approach has been successful during reservoir characterization, optimized well/pad placement, well/completion designs, regulatory and land operations. This paper summarizes the approach used to optimize primary production operations while generating waterflood development plans, including challenges and key learnings.
Get Everyone on the Same Curve: Driving Continuous Improvement with Drilling Data Fidelity from Rig to Onshore
Authors: Sharma Meenu , Little Robert , Arumugam Sethupathi , Wang Sophie 
Published: April 2017

Abstract
In recent times there has been a paradigm shift in drilling data consumption. From being utilized only by service companies on the rig, the data is now accessed and analysed by several global stakeholders. As the amount of data being received from multiple sources grows exponentially, more often than not, the data (both real time and historic) is inconsistent across multiple environments. The service companies, rig contractors, operators and onshore environment - each might have multiple variations for the same data. This not only jeopardises the decision making but can have significant financial and reputational repercussions as well. With increased reliance on data, it is advantageous to pay more attention to erroneous data.
This paper focuses on a systematic approach to identify, analyse and address the data fidelity issues triggered by inaccurate, incomplete or inconsistent data which acts as a catalyst in driving continuous improvements and assist decision making.
A comprehensive quantitative and analytical approach is followed to identify missing and non-identical logs and mnemonics that should have been replicated between rig and onshore servers. Various metadata attributes such as sampling frequency, run number, data row count, object growing, data gap, variance between start/end indexes are derived using ETL technique and WITSML API's. This information is used to arrive at definitive statistical indicators such as overall variance and data fidelity score (0-100%) to demonstrate data confidence levels. A case study for a set of rig-onshore environments is used to substantiate the findings. Data fidelity across multiple environments can be represented in a Venn diagram to detect points of failure in a complex rig-onshore server network. Finally, the results with right amount of analytical details are published to stakeholders to ensure easy data access to everyone in their decision making.
The effective use of metadata makes this light weight approach more useful where a full scale big data deployment will be impractical. The trends in data fidelity can be tracked over a prolonged period to ensure data consistency across the global rig fleet and drive continuous improvement in data governance standards, process and software implementation. A fine balance of high level reporting along with the ability to conduct deep dives and support root cause analysis provides powerful tools to various stakeholders.
This approach can be extended to include other WITSML objects to provide an end to end data integrity solution.
Acoustoelastic Estimation of the In Situ Stresses from Sonic Logs for a Carbonate Reservoir
Authors: Samnejad M.. , Aminzadeh F.. , Bubshait A.. 
Published: April 2017

Abstract
Knowledge of the magnitude of in situ stresses is crucial to a broad range of applications, particularly drilling, well completion, and hydraulic fracturing design. Stress field characterization is attained by the determination of magnitude and direction of the three principal stresses: the vertical or overburden stress (Sv), the minimum horizontal principal stress (Shmin), and the maximum horizontal principal stress (SHmax). While numerous direct borehole measurements, such as density logs and leak-off tests, provide reliable assessments of Sv and Shmin, estimating local SHmax remains a challenge.
This paper presents a workflow that provides with an approach for estimation and constraining of the maximum horizontal principal stress in a carbonate reservoir from borehole sonic logs, by comparison to the isotropic stress state. Our study was restricted to cases with limited achievable data, namely, conventional logs, which is expected to be the circumstances for most practical applications.
The results were compared to published regional stress reports, with the goal of validating and understanding the variations of stresses at the field scale. Those findings were in agreement with the estimations obtained from other acoustoelastic methods and the region fault regime in terms of the relative obtained magnitudes of the stresses. In addition to an increasing trend in the calculated stress magnitudes with depth, we observe local variations of stresses in this oilfield, that we suspected to be caused partially by the non-uniform distribution of production and injection activities.
The novelty of our proposed workflow is the ability to give borehole estimates of the maximum horizontal principal stress magnitude for a carbonate field located in a regionally compressive zone, without the need for availability of costly measurements, and by taking advantage of techniques to fill in the gaps of limited data, thus, allowing for integrative use of multiple data types that are commonly available.