bluuebunny/crossref_metadata_2025_split huggingface dataset:
Typology of esports crowdfunding investors
Authors: Oh Taeyeon , Lee Seomgyun 
Published: September 2024

PurposeOnline fundraising has become a rapidly growing alternative business financing method for esports. Despite this, a lack of attention has been given to its fans' motivations for participating in crowdfunding (CF) projects or behavioral intentions for spectatorship. To address this, the present study (1) categorizes esport CF investors' motivations based on the big five personality traits and (2) compares whether motivations and behavioral intentions for esports spectatorships vary depending on each group.Design/methodology/approachWe applied K-means clustering analysis to classify investors. ANOVA was used to verify whether there were differences in CF motivations and behavioral intentions.FindingsThe study identified six distinct investor segments. Overall, esports CF investors showed high agreeableness and conscientiousness with low neuroticism. Fanatic fans were the most motivated and had the highest spectatorship intentions, driven by strong openness. In contrast, recognition seekers and charity donors exhibited the lowest viewing intentions. Entertainment seekers were highly motivated by excitement and aesthetics, linking CF participation to a strong desire to watch events. Despite higher neuroticism, reward hunters also showed significant viewing intentions, driven by drama and aesthetics. These findings highlight the diverse motivations and their influence on esports spectatorship.Originality/valueThis study investigates the motivations and behavioral intentions of CF investors and spectatorship, which has substantive theoretical and managerial implications for the business of esports.
Is pollen limitation linked to phenotypic selection on floral traits in the carnivorous plant Pinguicula moranensis (Lentibulariaceae)?
Authors: Villegas Sara Gabriela , Domínguez César , Fornoni Juan , Ospina‐Garcés Sandra M. , Alcalá Raúl Ernesto 
Published: September 2024

AbstractIn carnivorous plants, the fitness impacts of phenotypic variation in traits involved in prey attraction and capture have been well documented. However, floral traits could also contribute to the fitness of carnivorous plants. Pinguicula moranensis is a carnivorous plant that presents colorful zygomorphic flowers, which suggests some degree of specialization in its interactions with pollinators. We first tested pollen limitation experimentally by comparing the fruit set in plants that were manually cross‐pollinated with those that were pollinated naturally. Then, using a path analysis approach, we explored the effects of plant size and floral traits (corolla shape, corolla size, spur length, nectar guide size, and stalk length) on fitness (seed number per fruit). We performed two independent path analyses—one with the naturally pollinated plants and the other with the hand pollinated plants—to consider the impacts of these variables with and without the pressure of pollinator attraction. We expected stronger selection on floral traits in naturally pollinated plants. We found evidence of pollen limitation in the fruit set of the naturally pollinated group, suggesting that pollinator availability could impose selective pressures. The path analyses showed a marked direct positive effect of rosette size on plant fitness in both groups. The direct effects of all floral traits had similar magnitudes between the naturally pollinated and hand pollinated plants, except for corolla shape that showed higher coefficients in the first group. Thus, although we evidenced pollen limitation, our prediction about the role of pollinators as selective agents of floral traits in P. moranensis was barely supported.
Review article: Strategies to improve emergency department care for adults living with disability: A systematic review
Authors: Newman Bronwyn , Cheek Colleen , Richardson Lieke , Gillies Donna , Hutchinson Karen , Austin Elizabeth , Murphy Margaret , Testa Luke , Rojas Christina , Raggett Louise , Dominello Amanda , Smith Kylie , Clay‐Williams Robyn 
Published: September 2024

AbstractEquitable access means that timely, sensitive and respectful treatment is offered to all people. Adults with disability access ED care more frequently than the general population. However, in Australia and internationally, people with disability experience poorer healthcare access and outcomes than the general population. There is acknowledgement that ED environments and processes of care could be better designed to promote equitable access, so as not to further disadvantage, disable and create vulnerability. This systematic review aimed to locate and describe evaluated strategies implemented to improve care for people with disability (aged 18–65 years) in the ED. Four databases were searched from inception to June 2024. 1936 peer‐reviewed papers were reviewed by pairs of independent reviewers. Four studies met our inclusion criteria, demonstrating the limited peer‐reviewed literature reporting on evaluated strategies to improve ED care for adults aged 18–65 years. Three studies focused on the needs of people with intellectual disability, and one created a specific treatment pathway for people experiencing status epilepticus. No studies evaluated across patient experience, patient outcomes, system performance and staff experience, with limited evaluation of patient outcomes and system performance measures. We have referenced helpful resources published elsewhere and drawn from our previous reviews of ED care to provide guidance for the development and evaluation of targeted initiatives.
Are histomorphological patterns a predictor for survival in uveal melanoma patients with hepatic metastases undergoing hepatic artery infusion chemotherapy?
Authors: Steinberg‐Vorhoff Hannah L , Ting Saskia C , Zensen Sebastian , Ludwig Johannes M , Li Yan , Richly Heike , Grüneisen Johannes , Siveke Jens T , Theysohn Jens M , Schaarschmidt Benedikt M 
Published: September 2024

AbstractIntroductionIn uveal melanoma (UM) patients with hepatic metastases, hepatic artery infusion chemotherapy (HAIC) is a viable, palliative treatment option. To evaluate the impact of two histomorphological patterns (spindle cell vs. epithelioid) of liver metastases on median overall survival (mOS) in UM patients undergoing HAIC.MethodsA retrospective analysis with 60 UM patients (29 females, mean age: 61.6 ± 12.1 years) with hepatic metastases was performed. Histomorphological patterns in metastases were analysed and classified as either predominant spindle cell or epithelioid pattern. mOS between both patient groups was analysed using Kaplan–Meier curves and the log‐rank test.ResultsIn 73.3% (44/60) of the metastases, a predominant epithelioid pattern, in 21.7% (13/60) a predominant spindle cell pattern, and in 5% (3/60) other patterns were found. No significant differences between patients with an epithelioid (mOS: 14.2 months, 95% CI: 8.8–19.6) and a spindle cell pattern (mOS: 14.4 months, 95% CI: 4.3–24.5) were detected by the log‐rank test, χ2(2) = 0.22, P = 0.881.ConclusionHistomorphological patterns of UM metastases do not seem to be a predictor for mOS in UM patients undergoing HAIC.
Prevalence and etiology of ventilator‐associated pneumonia during the COVID‐19 pandemic in Denmark: Wave‐dependent lessons learned from a mixed‐ICU
Authors: Grzywacz Joanna , Ahlström Magnus G. , Benfield Thomas , Berg Ronan M. G. , Plovsing Ronni R. , Ronit Andreas 
Published: September 2024

AbstractBackgroundVentilator‐associated pneumonia (VAP) may be a particular concern in patients with severe coronavirus disease 2019 (COVID‐19). We aimed to determine the prevalence and etiology of VAP in critically ill COVID‐19 patients in a Danish intensive care unit (ICU) during the first three waves of the COVID‐19 pandemic and to study associations between dexamethasone (DXM) use and development of VAP.MethodsIn an observational single‐center study patients were retrospectively screened for VAP including causative pathogens, use of DXM and commonly used antibiotics. Diagnosis of VAP required invasive mechanical ventilation (IMV) >48 h with presence of a new bacterial agent and clinical signs of infection. For analysis, common descriptive statistics were applied. Cox proportional hazards models were used to analyze the association between DXM use and VAP.ResultsVAP was detected in 53/119 (44.5%) mechanically ventilated patients across all three COVID‐19 waves. Median length of IMV for VAP patients was 24 [15–41] days, and 3 out of 4 were males. VAP was most prevalent (47.0%) during the second wave. Common pathogens included Klebsiella pneumoniae (24.5%), Enterobacter aerogenes (17.0%) and Pseudomonas aeruginosa (13.2%), Staphylococcus aureus (13.2%), and Escherichia coli (13.2%). A change from Gram‐negative bacteria only to a combination of Gram‐positive and Gram‐negative bacteria was observed in the second wave compared to first. Use of DXM was not associated with VAP (adjusted hazard ratio 1.63 95% CI: 0.84–3.17).ConclusionThe prevalence of VAP was high across all three COVID‐19 waves and showed a different distribution of pathogens between the first and second wave. Use of DXM was not associated with VAP development. Further and larger studies are needed to understand the risk factors associated with VAP in patients with COVID‐19.
Concentration‐QTc analysis of soticlestat in healthy adults: An alternative to a thorough QT study
Authors: Yin Wei , Dote Nobuhito , Fukase Hiroyuki , Imazaki Manami , Shimizu Kohei , Takeda Shinichi , Darpo Borje , Xue Hongqi , Asgharnejad Mahnaz 
Published: September 2024

AbstractAimThis study aimed to examine the cardiac and overall safety and pharmacokinetic (PK) profiles of soticlestat (TAK‐935), an oral, first‐in‐class selective cholesterol 24‐hydroxylase inhibitor.MethodsData came from a randomised, phase 1 study of soticlestat in 33 healthy Japanese adults (NCT04461483); 24 adults in Part 1 (single‐dose soticlestat 200‐1200 mg or placebo) and 9 in Part 2 (soticlestat 100‐300 mg twice daily or placebo for 21 days). PK sample collection was paired with 12‐lead electrocardiogram data from continuous Holter recordings. The concentration‐QTc relationship was analysed using a linear mixed‐effects model. QTc prolongation safety margins were determined for two scenarios of calculated high clinical exposures: scenario 1 (NCT05064449) involved coadministration of single‐dose soticlestat 300 mg with itraconazole or mefenamic acid and scenario 2 (NCT05098054) involved single‐dose soticlestat 300 mg administration in participants with mild/moderate hepatic impairment (implementing a 3‐fold dose reduction for moderate severity).ResultsBased on concentration‐QTc analysis, placebo‐corrected change‐from‐baseline QT values (90% confidence intervals), corrected for heart rate (Fridericia's method), were 0.94 ms (−2.35, 4.23) for soticlestat and 0.63 ms (−3.15, 4.41) for its N‐oxide metabolite plasma concentrations at therapeutic doses (soticlestat 300 mg twice daily); safety margins were >2‐fold for scenarios of calculated high clinical exposures. No (Part 1) and five (83.3%; Part 2) participants experienced treatment‐emergent adverse events (all mild).ConclusionThere was no evidence for QT prolongation with soticlestat at therapeutic doses or in two scenarios of high clinical exposures, which resulted in regulatory agencies waiving requirements of a thorough QT study. Safety/PK findings aligned with previous soticlestat clinical studies.
Population pharmacokinetics of long‐term hydroxychloroquine therapy in patients with rheumatic diseases
Authors: Yang Chunlan , Deng Yiyun , Liu Hui , Song Shuai , Jiu Jiatao , Pan Menglu , Xia Quan , Xu Dujuan , Wu Ye , Su Yong 
Published: September 2024

AimsHydroxychloroquine (HCQ) is recommended for the long‐term treatment of rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus. Given the complex process of HCQ metabolism and individual physiological differences, the metabolic profile of HCQ after long‐term administration is unknown. This study aimed to establish a population pharmacokinetic model for long‐term HCQ treatment in patients with rheumatic diseases and to identify the factors influencing HCQ metabolism.MethodsThis study included 274 HCQ whole‐blood trough concentration data points from 203 patients with rheumatic diseases, all of whom had taken HCQ for more than 6 months, with a median duration of 36 months. A nonlinear mixed‐effects model was derived to establish a population pharmacokinetic model, and potential influencing factors were investigated. Different covariates were used to simulate the optimal dose.ResultsThe final model describing the HCQ blood concentration–time profile was a compartmental model with first‐order absorption. The estimated values for apparent clearance and volume of distribution were 16.4 L/h and 1220 L, respectively. The clearance of HCQ gradually increased with increasing dosing regimens and weight gain. Monte Carlo simulations were used to determine the optimal dosage regimens for patients with different body weights and drug durations. The simulation results revealed that an initial dose of 5 mg/kg was appropriate.ConclusionsWe developed a population pharmacokinetic model for long‐term HCQ therapy in patients with rheumatic diseases. HCQ clearance from whole blood increased progressively with increasing duration of drug administration.
Targeted proteomics profiling reveals valuable biomarkers in the diagnosis of primary immune thrombocytopaenia
Authors: Jiang Yizhi , Li Jizhe , Huang Jun , Zhang Zichan , Liu Xiaocen , Wang Nana , Huang Chen , Wang Ran , Zhang Lanxin , Han JingJing , Bai Xia , Huang Dongping , Zhou Lu 
Published: September 2024

SummaryThe lack of biomarkers for accurate diagnosis and prognosis is a major clinical challenge of primary immune thrombocytopaenia (ITP). Using an Olink proteomics platform with a 92 immune response‐related human protein panel, we analysed plasma samples from ITP patients (ITP, n = 40), patients with thrombocytopaenia secondary to other causes (Non‐ITP, n = 19) and healthy controls (NC, n = 18), of a discovery cohort as well as a validation cohort (ITP, n = 36; NC, n = 20). A total of 10 differentially expressed proteins (DEPs) were identified in the ITP group compared with the non‐ITP and NC groups of the discovery cohort. These include CXCL11, GZMH, ARG1, TGF‐β1, ANGPT1, CXCL12, CD40‐L, PDGF subunit B, IL4 and TNFSF14. Furthermore, least absolute shrinkage and selection operator regression analysis showed some of these DEPs, such as CXCL11, TGF‐β1, ARG1 and GZMH to be significant in differentiating between patients with ITP and healthy controls (validation area under the curve = 0.87). The analysis demonstrated that the ITP group has a specific proteomic profile relative to non‐ITP and NC groups. In summary, we report for the first time that Olink precision proteomics can specifically detect up‐regulated inflammatory proteins as potential diagnostic biomarkers for ITP.
Vertebrate seed predation can limit recruitment of later‐successional species in tropical forest restoration
Authors: Joyce Francis H. , Ramos Brianna M. , Zahawi Rakan A. , Holl Karen D. 
Published: September 2024

AbstractThe effects of vertebrate seed predation on the regeneration of restored forests are not well understood because most past studies have focused on seed predation within the first few years after restoration and have measured seed removal without quantifying subsequent seedling establishment of seeds that avoid predation. Quantifying the establishment of seeds that escape predation in restored forests at later stages of regrowth is crucial for anticipating longer‐term recovery trajectories. Here, we evaluated the potential role of vertebrate seed predators in limiting recruitment of later‐successional tree species in nine forests actively restored ≥15 years prior and in four paired remnant forest fragments embedded in an agricultural landscape in southern Costa Rica. We conducted seed addition experiments with four tree species inside and outside vertebrate exclosures and used camera trapping to detect seed predators. To determine the fate of seeds that avoided predation, we also measured seedling establishment after 1 year, given that other mortality factors may compensate in the absence of vertebrate seed predation. We detected two species of birds and five species of granivorous mammals removing seeds. Seed tagging indicated that most removal resulted in predation. For three of the four tree species tested, vertebrate seed predation reduced seedling establishment. The magnitude of this effect depended on species' susceptibility to other causes of mortality during the seed‐to‐seedling transition. Our study demonstrates that vertebrate seed predators can substantially reduce later‐successional seedling recruitment in restored forests and should be considered alongside dispersal limitation and microsite conditions as factors slowing forest recovery.Abstract in Spanish is available with online material.
The association between wet work and hand eczema in the Dutch general population: Application of a job exposure matrix to the lifelines cohort study
Authors: Brands Marjolein J. , Loman Laura , Lund Tamara T. , Flachs Esben M. , Bültmann Ute , Schuttelaar Marie L. A. 
Published: September 2024

AbstractBackgroundStudies on wet work and hand eczema (HE) frequently rely solely on self‐reports regarding wet work.ObjectivesTo assess the association between wet work and moderate‐to‐very‐severe HE, within the Dutch general population, by using a (sex‐specific) job exposure matrix (JEM).MethodsWithin the Lifelines Cohort Study, participants with self‐reported moderate‐to‐very‐severe HE at worst in the past year were linked to data from the Danish (sex‐specific) wet work JEM, a tool that links occupations with wet work indices (including duration and probability of glove use, wet hands and total wet work for at least 2 and 4 h/working day).ResultsIn total, 56 978 (41.9%) participants were included. The multivariate binary logistic regression analyses showed significant associations between all facets of wet work and moderate‐to‐very‐severe HE. When using the sex‐specific JEM, significant associations were found in females, but not in males.ConclusionsThis study is the first to use a wet work‐specific JEM in a general population sample, and found positive associations between wet work and HE. The sex‐specific findings should be interpreted with caution, due to limitations inherent in using a JEM, and should be further explored with observational studies, with a focus on duration, frequency, and exposure type.
Comparison Between Endobronchial‐Guided Transbronchial Biopsy and Computed Tomography–Guided Transthoracic Lung Biopsy for the Diagnosis of Central Pulmonary Lesions
Authors: Zhang Cheng , Zhu Senlin , Yuan Yanliang , Dai Shenhui 
Published: September 2024

ABSTRACTBackgroundLung cancer is one of the most common malignant tumors at present. This study aimed to compare the diagnostic accuracy, complication rates, and predictive values of computed tomography (CT)–guided percutaneous transthoracic needle biopsy (PTNB) and electronic bronchoscopy–guided transbronchial lung biopsy (TBLB) for patients with central pulmonary lesions (CPLs) with a diameter ≥ 3 cm.MethodsWe retrospectively included 110 patients with CPLs with a diameter ≥ 3 cm who underwent preoperative PTNB and TBLB examinations and ultimately underwent surgery to remove CPLs and obtained pathological results. Detailed information was collected in order to compare whether there was a difference between two groups. Data were processed using SPSS software (Version 26.0; IBM Corp). Data were compared by t‐test or chi‐square test. p < 0.05 was considered statistically significant.ResultsAll patients underwent surgical treatment at the department of thoracic surgery and obtained a final pathological diagnosis. The rate of positive predictive value (PPV) was comparable between the two methods, and the negative predictive value (NPV) was significantly higher in the PTNB group compared with the TBLB group (p < 0.05). In addition, PTNB was more sensitive and accurate than TBLB (p < 0.05). However, the PTNB group had a higher probability of complications, and TBLB was a relatively safer examination method.ConclusionPTNB demonstrated a higher accuracy and sensitivity than TBLB in the treatment of CPLs with a diameter ≥ 3 cm, but the complication rates of PTNB are relatively high. These methods exhibited different diagnostic accuracies and therefore should be selected based on different medical conditions.
A structural equation model of parenting and child's resilience after the earthquake in Türkiye
Authors: Kuru Nilüfer , Ungar Michael 
Published: September 2024

AbstractThis study investigated the relationship between parental psychological wellbeing, parenting, children's psychological difficulties, and prosocial behavior in Kahramanmaraş earthquake‐affected families living in Türkiye in 2023. To this end, a mediation model was proposed for parental psychological distress that was hypothesized to exert an indirect effect on a child's psychological difficulties and prosocial behavior through parenting. Participants were 358 preschoolers between 4 and 6 years old and their one parent (father or mother) who completed a set of validated self‐report surveys in a cross‐sectional design study. Results showed positive associations between parental psychological distress and child's psychological difficulties but negative association with child's prosocial behavior. Furthermore, quality of parenting mediated the association between parental psychological distress and child's psychological difficulties and prosocial behavior. Our findings suggest that positive parenting may serve as a protective mechanism that mediates the association between parental psychological distress and a child's psychological difficulties and prosocial behaviors among families displaced by a natural disaster like an earthquake. These findings point to the need for supporting positive parent–child relationships in addition to decreasing the psychological distress of parents when exposed to potentially traumatizing events like this.
Is the population of kingfish (Scomberomorus commerson) in the northern Persian Gulf really under pressure from overfishing?
Authors: Divani Taher , Haghi Mahsa , Zare Parviz 
Published: September 2024

AbstractQuantifying the population dynamics of marine species is difficult when good, comprehensive data are not available. We sought to determine if the kingfish Scomberomorus commerson stock in the Persian Gulf was overfished. The ICES data‐limited assessment framework was used to provide precautionary advice, with a 20% decrease advised in situations where only catch or bycatch data were available. The length‐based Bayesian biomass (LBB) was used to model fork length from landing records of licensed fishers in the Khuzestan Province during 2002–2018, which had increased despite sought being overexploited. Most kingfish were immature and smaller than optimum length of the catch (Lc‐opt = 88 cm) and optimum length (Lopt = 104 cm). Relative biomass (B/Bmsy) ranged 0.62–0.66 and exceeded 0.5. The B/Bmsy ratio (1.25) was >1.1. The stock appeared to be healthy and exploitable, but wide confidence intervals of the B/Bmsy ratio complicated interpretation of stock status. The kingfish stock appeared to use waters of the study area as a spawning and nursery ground, so many young immature individuals were present. If current exploitation of young individuals continues, this the stock will eventually be overfished. Long‐term increases in the catch of young immature kingfish can have a side effect on stock maturation and recruitment. We recommend that the mesh size of fishing gear be selected based on optimum length, to enhance economic, and commercial viability of the kingfish fishery.