bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of the Kaufman Speech to Language Protocol for Children With Childhood Apraxia of Speech and Comorbidities When Delivered in a Dyadic and Group Format
Authors: Namasivayam Aravind K. , Cheung Karina , Atputhajeyam Bavika , Petrosov Julia , Branham Miriam , Grover Vikas , van Lieshout Pascal 
Published: October 2024

Purpose:
The current study is a Phase I clinical study with the goal of determining feasibility and the effectiveness of the Kaufman Speech to Language Protocol (K-SLP) for children with childhood apraxia of speech (CAS) and comorbidities. We hypothesized that K-SLP intervention would result in improved outcomes and maintenance of treatment effect at 3–4 months postintervention.

Method:
Single-subject experimental design with multiple baselines across behaviors was replicated across a group of six children. Five out of six participants completed the study. The K-SLP intervention was administered in dyads four times a week for three consecutive weeks. Outcomes included assessment of word/syllable shapes, articulation accuracy, speech intelligibility, and functional communication. Treatment progress was measured through: (a) the administration of custom probe word lists and (b) assessments carried out at pretreatment, immediately following intervention and approximately 3–4 months after the study period.

Results:
Four out of five participants demonstrated significant improvements to words targeted in treatment and three out of five generalized these to untreated words. Furthermore, three out of five participants showed immediate and clinically significant posttreatment improvements in speech intelligibility and functional outcomes, and this increased to four out of five participants at 3–4 months follow-up.

Conclusions:
The study provides preliminary support for the effectiveness of the K-SLP program when delivered in dyads to children with CAS with comorbidities. The study replicates earlier findings and reaffirms the positive outcomes of K-SLP for children with CAS.
Vocal Characteristics of Children With Cerebral Palsy and Anarthria
Authors: Long Helen L. , Hustad Katherine C. 
Published: October 2024

Purpose:
This study aimed to investigate the vocal characteristics of children with cerebral palsy (CP) and anarthria using the stage model of vocal development.

Method:
Vocal characteristics of 39 children with CP and anarthria around 4 years of age were analyzed from laboratory-based caregiver–child interactions. Perceptual coding analysis was conducted using the Stark Assessment of Early Vocal Development–Revised to examine vocal complexity, volubility, and consonant diversity.

Results:
Children predominately produced vocalizations corresponding to the two earliest stages of vocal development characterized by vowel-like utterances. They showed a limited attainment of consonantal features with low consonant diversity and variably low vocal rates.

Conclusions:
Our results demonstrate that underlying neurological impairments resulting in an anarthric status in children with CP affect the progression of speech motor development and their ability to advance beyond early vocal stages. These findings highlight the importance of considering alternative communication modalities for children demonstrating similar vocal characteristics beyond expected periods of development.
Firsttrimester Diagnosis and Therapy @ 11–13+6 Weeks of Gestation – Part 2
Authors: von Kaisenberg Constantin , Kozlowski Peter , Kagan Karl-Oliver , Hoopmann Markus , Heling Kai-Sven , Chaoui Rabih , Klaritsch Philipp , Pertl Barbara , Burkhardt Tilo , Tercanli Sevgi , Frenzel Jochen , Mundlos Christine 
Published: October 2024

This extensive AWMF 085-002 S2e-guideline “First Trimester Diagnosis and Therapy @ 11–13+6 Weeks of Gestation” has systematically analyzed high-quality studies and publications and the existing evidence (evidence tables) and produced recommendations (level of recommendation, level of evidence, strength of consensus).This guideline deals with the following topics in the context of the 11–13+6 weeks scan: the legal basis, screening for anatomical malformations, screening for chromosomal defects, quality assessment and audit, screening for preeclampsia and FGR, screening for preterm birth, screening for abnormally invasive placenta (AIP) and placenta accreta spectrum (PAS), screening for velamentous cord insertion and vasa praevia, screening for diabetes mellitus and LGA.Screening for complications of pregnancy can best be carried out @ 11–13+6 weeks of gestation. The issues of how to identify malformations, chromosomal abnormalities and certain disorders of placentation (high blood pressure and proteinuria, intrauterine growth retardation) have been solved. The problem of how to identify placenta percreta and vasa previa has been partially solved. What is still unsolved is how to identify disorders of glucose metabolism and preterm birth.In the first trimester, solutions to some of these problems are available: parents can be given extensive counselling and the risk that a pregnancy complication will manifest at a later stage can be delayed and reduced. This means that screening is critically important as it helps in decision-making about the best way to manage pregnancy complications (prevention and intervals between follow-up examinations).If no treatment is available and if a termination of pregnancy is considered, the intervention can be carried out with far lower complications compared to the second trimester of pregnancy. In most cases, further examinations are not required and the parents can be reassured. A repeat examination at around week 20 of gestation to complete the screening for malformations is recommended.
Note The guideline will be published simultaneously in the official journals of both professional societies (i.e. Ultraschall in der Medizin/European Journal of Ultrasound for the DEGUM and Geburtshilfe und Frauenheilkunde for the DGGG).
Firsttrimester Diagnosis and Therapy @ 11 – 13+6 Weeks of Gestation – Part 2
Authors: von Kaisenberg Constantin , Kozlowski Peter , Kagan Karl-Oliver , Hoopmann Markus , Heling Kai-Sven , Chaoui Rabih , Klaritsch Philipp , Pertl Barbara , Burkhardt Tilo , Tercanli Sevgi , Frenzel Jochen , Mundlos Christine 
Published: October 2024

AbstractThis extensive AWMF 085-002 S2e-guideline “First Trimester Diagnosis and Therapy @ 11 – 13+6 Weeks of Gestation” has systematically analyzed high-quality studies and publications and the existing evidence (evidence tables) and produced recommendations (level of recommendation, level of evidence, strength of consensus).This guideline deals with the following topics in the context of the 11 – 13+6 weeks scan: the legal basis, screening for anatomical malformations, screening for chromosomal defects, quality assessment and audit, screening for preeclampsia and FGR, screening for preterm birth, screening for abnormally invasive placenta (AIP) and placenta accreta spectrum (PAS), screening for velamentous cord insertion and vasa praevia, screening for diabetes mellitus and LGA.Screening for complications of pregnancy can best be carried out @ 11 – 13+6 weeks of gestation. The issues of how to identify malformations, chromosomal abnormalities and certain disorders of placentation (high blood pressure and proteinuria, intrauterine growth retardation) have been solved. The problem of how to identify placenta percreta and vasa previa has been partially solved. What is still unsolved is how to identify disorders of glucose metabolism and preterm birth.In the first trimester, solutions to some of these problems are available: parents can be given extensive counselling and the risk that a pregnancy complication will manifest at a later stage can be delayed and reduced. This means that screening is critically important as it helps in decision-making about the best way to manage pregnancy complications (prevention and intervals between follow-up examinations).If no treatment is available and if a termination of pregnancy is considered, the intervention can be carried out with far lower complications compared to the second trimester of pregnancy. In most cases, further examinations are not required and the parents can be reassured. A repeat examination at around week 20 of gestation to complete the screening for malformations is recommended.
Note: The guideline will be published simultaneously in the official journals of both professional societies (i.e. Ultraschall in der Medizin/European Journal of Ultrasound for the DEGUM and Geburtshilfe und Frauenheilkunde for the DGGG).
Effects of Progesterone on Vasomotor Symptoms in Postmenopausal Women (PROGEST) – a Prospective Multi-Center Randomized Double-Blind Placebo-Controlled Trial (RDPCT)
Authors: Beinert Sissi Valentina , Kleinsorge Frauke , Worm Julia , Tropschuh Katharina Victoria , Seifert-Klauss Vanadin 
Published: October 2024

Abstract
Introduction Monotherapy with progesterone for treatment of vasomotor symptoms (VMS) was more effective than placebo treatment of postmenopausal healthy women in a Canadian trial. The PROGEST-trial was initiated to fulfill FDA-approval criteria for the indication of treatment of postmenopausal VMS.
Methods This prospective randomized, double-blind placebo-controlled clinical trial studied three doses of oral micronized progesterone (200 mg, 300 mg, 400 mg) and placebo for 12 weeks. Postmenopausal women with moderate to severe VMS (> 50 per week) were screened for one week for VMS frequency, then randomized to 200, 300 or 400 mg progesterone daily or placebo for a double-blinded trial of 12 weeks duration.
Results 74 women were recruited in 12 study centers. 44 terminated the study as per protocol (PP). Moderate to severe hot flushes decreased by 7.4/d in the placebo arm, 7.7 VMS/d with 200 mg/d progesterone (P4), 8.3 VMS/d on 300 mg/d and 9.0 VMS/d on 400 mg/d P4, respectively by week 12. 32 treatment emergent adverse events were documented in 18 participants, mostly minor AEs. The only SAE was a syncope requiring hospitalization on the day after treatment initiation, leading to discontinuation of the drug.
Discussion Baseline VMS frequency was much higher in the German than in the Canadian study and the course of the placebo group had a markedly stronger decrease in VMS-frequency during the PROGEST study (−7.4/d) than in the Canadian trial (−1.4/d). Trial populations differed by age, BMI, the number of women with natural menopause, and comorbidities, mainly hypertension.
Conclusion Premature discontinuation of the trial due to insufficient subject accrual rate led to only 55 randomized participants for analysis, therefore the study results lack statistical power. Still, a slight dose-dependent improvement in VMS was seen for all doses, while AE frequency did not increase with progesterone dose.
Technical and clinical success analysis of transarterial embolization therapy in type II endoleaks following endovascular aortic repair
Authors: Krompaß Kristina , Grunz Jan-Peter , Augustin Anne Marie , Peter Dominik , Schönleben Frank , Bley Thorsten , Kickuth Ralph 
Published: October 2024

AbstractThis single-center study investigated the safety and efficacy of transarterial embolization of type II endoleaks for expanding aneurysm sacs following endovascular aortic repair (EVAR).36 patients (33 men, 75.9±6.6 years) underwent a total of 50 endovascular procedures for type II endoleak embolization between 2008 and 2023. Analyses included the assessment of patient risk profiles, aneurysm morphology, and endoleak characteristics. Outcome parameters comprised the technical success (i.e., complete lack of blood flow in the previously perfused aneurysm sac) and complication rates, while clinical success was defined as the absence of endoleak persistence or recurrence and freedom from aneurysm enlargement > 0.5 cm over the follow-up period.Transarterial embolization was technically successful in 84% of procedures with a complication rate of 2%. Most interventions were coil-based (72%), while a small number relied solely on liquid embolic agents (14%). Absence of a persisting endoleak in the earliest follow-up could be demonstrated in 75.6% of cases, whereas the absence rate for endoleak recurrence was substantially lower (46.3%). No aneurysm enlargement > 0.5 cm during follow-up was ascertained after 73.2% of interventions.Transarterial embolization represents a safe treatment for type II endoleaks after EVAR. While embolization was moderately effective in preventing further expansion of aneurysms due to endoleak recurrence, most procedures were successful in permanently eliminating the targeted feeder vessels.
Soll ich bleiben oder soll ich gehen? Resilienz, Kündigungsabsicht
und Arbeitszufriedenheit von Krankenpflegefachkräften auf
Intensivstationen
Authors: Füreder Nina , Herber Gabriele , Stadlmayr Elke 
Published: October 2024

Zusammenfassung
Ziel Die Bewältigung des weltweiten Mangels an Pflegekräften trägt zu den
nationalen und internationalen Bemühungen bei, die Gesundheit und das
Wohlbefinden der Weltbevölkerung zu sichern. Das Ziel dieses Beitrages besteht
darin, auf die Bedeutung der Resilienz und dessen Einfluss auf die
Kündigungsabsichten und die Arbeitszufriedenheit unter den aktuellen
Herausforderungen von Krankenpflegefachkräften hinzuweisen.
Methodik Es handelt sich um ein Mixed-Methods-Design mit diplomierten
Krankenpflegefachkräften auf Intensivstationen eines Universitätskrankenhauses
in Österreich. In der ersten Phase der Datenerhebung wurden mittels qualitativen
Fokusgruppeninterviews Daten zu den aktuellen Herausforderungen und Belastungen
der Fachkräfte erhoben. Unter Bezugnahme auf relevante Literatur wurde im
darauffolgenden Schritt eine quantitative Erhebung mit den Skalen Resilienz,
Kündigungsabsicht und Arbeitszufriedenheit, unter allen Pflegefachkräften
durchgeführt, um die Zusammenhänge der ausgewählten Variablen zu untersuchen.
Darüber hinaus konnte mithilfe der konfirmatorischen Faktorenanalyse eine
Datenstrukturierung der Resilienz Skala erzielt werden. Im Anschluss wurden die
Zusammenhänge der Resilienz-Subfaktoren mit den anderen Variablen mittels einer
weiterführenden Korrelations-, Regressions- und Mediationsanalyse
untersucht.
Ergebnisse Die Ergebnisse zeigen negative Zusammenhänge hinsichtlich
Resilienz und Kündigungsabsicht sowie in Bezug auf Arbeitszufriedenheit und
Kündigungsabsicht. Demgegenüber korrelieren Arbeitszufriedenheit und Resilienz
stark positiv miteinander. Der negative Zusammenhang zwischen Resilienz und
Kündigungsabsicht differenzierter betrachtet insbesondere für die Faktoren
„Zielfokussierung“ und „Stolz und Bindung“. Betrachtet man die beiden Faktoren
und die dazugehörigen Items genauer, lässt sich eine Verbindung zur
Berufsidentität bzw. zur organisationalen Identität erkennen.
Schlussfolgerungen Die Studie liefert wertvolle Erkenntnisse für
Führungskräfte in der allgemeinen Gesundheitspraxis und für
Entscheidungsträger*innen im Gesundheitswesen, um das Pflegepersonal in der
medizinischen Grundversorgung effektiv zu führen, zu entwickeln und dadurch zu
halten. Die Autorinnen argumentieren, dass die Förderung der Resilienz und die
Stärkung der organisationalen Identität wesentliche Einflussfaktoren für eine
höhere Arbeitszufriedenheit und eine Verringerung der Kündigungsabsicht des
Pflegpersonals sind.
Spontaneous Umbilical Cord Vascular Rupture during Labor: A Retrospective Analysis of 12 Cases
Authors: Chen Ruiyun , Lin Lin 
Published: October 2024

Objective Umbilical cord vascular rupture is a rare and severe condition that can occur during labor, leading to adverse outcomes for the fetus before as well as after delivery. Prompt diagnosis and intervention are crucial for improving the chances of a successful outcome. We aimed to analyze cases of umbilical cord vascular rupture during labor to provide insights into this challenging condition.
Study Design This retrospective study evaluated the medical records of patients diagnosed with umbilical cord vessel rupture or umbilical cord hematoma at Fujian Maternity and Child Health Hospital from January 1, 2015, to May 31, 2023. The inclusion criteria included gestational age of ≥28 weeks, occurrence during labor, and availability of complete delivery data. Data on fetal heart rate (FHR) changes, delivery intervals, intraoperative findings, placental pathology, and neonatal outcomes were collected and analyzed.
Results A total of 12 cases were analyzed. The incidence of umbilical cord vascular rupture during childbirth was 0.08%. The FHR patterns in umbilical cord rupture during delivery included baseline tachycardia, minimal or absent variability, variable or late deceleration, prolonged deceleration, and undetectable heart rate. The bradycardia-to-delivery interval (BDI) ranged from 6 to 26 minutes. Among the 12 neonates, 9 were discharged well, 2 were stillbirths, and there was 1 neonatal death. Hemorrhagic shock was common in live births.
Conclusion Our study highlights the significance of continuous FHR monitoring during labor and the urgent need for medical teams to respond quickly in cases of umbilical cord vascular rupture. Despite advancements in neonatal resuscitation techniques, managing cases with undetectable fetal heart activity remains clinically challenging, and even with immediate pregnancy termination, poor neonatal outcomes may still occur.
Key Points
The Retrosynthesis Mindset: A Problem-Solving Tool
Authors: Milić Jovana V. , Fung Fun Man , Choo Yvonne S. L. , Kolanowski Jacek L. 
Published: October 2024

AbstractRetrosynthesis refers to the process of deconstructing a target molecule step by step until simpler and commercially available synthetic precursors are identified to develop a valid synthetic pathway. As a powerful problem-solving tool, it has gradually been expanded to other fields of chemistry. The application of a ‘retrosynthesis mindset’ can be relevant beyond chemistry, such as in education, research management, and science advice. In this Letter, we discuss the concept of the retrosynthesis mindset and its implications within and beyond chemistry in the hope of highlighting a broader potential and encouraging the adoption of such a mindset to enhance problem solving and strategic planning across disciplines.1	Introduction2	Retrosynthesis Education3	Retrosynthesis Within and Beyond the Lab4	Conclusion
Comparison of Frequently Used Fever Measurement Methods: Which One is the Best?
Authors: Aydın Cansu , Bayhan Gülsüm İclal 
Published: October 2024

Abstract
Objective Peripheral measurement sites and methods used to determine core body temperature were investigated, as there is still debate about which noninvasive core body temperature measurement method is the most valuable and accurate for each age group.
Methods Children aged 1 to 36 months were included in the study. The temperature was measured from the forehead (noncontact cutaneous), temporal artery (TA), axilla, and rectum. The rectal measurement was accepted as the reference measurement. A rectal temperature of ≥38.3°C was defined as fever.
Results The noncontact cutaneous, axillary, and TA measurements were 1.2, 1.1, and 0.7°C lower than rectal measurements, respectively (p < 0.001, <0.001, <0.001). The TA and noncontact cutaneous measurements demonstrated a moderate positive correlation with rectal measurements, whereas a strong positive correlation was seen between the axillary and rectal measurements. A cutaneous temperature of 37.8°C was found to have a positive predictive value (PPV) of 100%, negative predictive value (NPV) of 81%, sensitivity of 34%, and specificity of 100% for detecting fever. The respective values were 80, 79.4, 23.5, and 98% for an axillary temperature of 37.5°C, and 90, 86.2, 52.9, and 98% for a TA temperature of 38°C.
Conclusion The commonly used fever measurement methods have high PPV and NPV and specificity but low sensitivity.
Preventable Hospital Admission-associated VTE: Thoughts on Thromboprophylaxis as Asians
Authors: D. Maran Esan Saciin , Er Chaozer , Gohar Sandeep , Adamjee Thofique 
Published: October 2024

AbstractPrevious studies surveying senior and junior doctors have shown that thromboprophylaxis was not commonly practiced in hospitalized medical patients in three public hospitals in Singapore. We, therefore, conducted an audit of our hospital's venous thromboembolism (VTE) clinic cases to study the proportion of preventable hospital admission-associated VTE (HAAVTE). All newly diagnosed VTE cases referred to our VTE clinic from March 2023 to December 2023 were reviewed, to identify those potentially associated with recent hospital admissions. We then reviewed the medical records of those cases to see if thromboprophylaxis was prescribed if indicated. HAAVTEs that had high VTE risk and did not receive appropriate thromboprophylaxis (pharmacological or mechanical) were considered preventable HAAVTE. Thirteen cases of HAAVTEs were identified, out of which only one was given the appropriate thromboprophylaxis. The proportion of preventable HAAVTE was 92.3%. Thromboprophylaxis is not widely practiced in our hospital. More effort is required to improve local thromboprophylaxis practice for hospitalized patients to reduce the burden of preventable HAAVTE.
Optimization of W-band interaction structure developed using three different micro-fabrication techniques
Authors: Jain Sahil , Vishant  , Kaur Maninder , Kumar Niraj 
Published: October 2024

In this paper, an experimental investigation has been performed for the three different micro-fabrication techniques for optimization in the development process of the W-band planar beam–wave interaction structure. The W-band planar beam–wave interaction structure has been developed using three different micro-fabrication methods, namely micro-EDM (electric discharge milling), wire-EDM, and micro-milling. The effect of each fabrication method on the developed structure is analyzed using scanning electron microscopy and ZETA 3D optical microscopy for their optimization. The experimental analysis has been performed for the developed W-band planar beam–wave interaction structure with an optimized process to achieve a dimensional deviation of less than 10 μm and surface roughness of less than 50 nm.
Development and construction of a cost-effective non-contact instrument for measuring the dielectric constant of liquids
Authors: Hassanpouryouzband Akram , Ahadzadeh Iraj , Mehrdad Abbas , Panahpour Somayyeh 
Published: October 2024

This research presents the development and construction of a cost-effective instrument, designed to measure the dielectric constant of liquids by employing a non-contact method that relies on determining the capacitance of a cell containing the liquid and its relaxation frequency. This instrument utilizes an astable multi-vibrator integrated with a resistance–capacitor network, in which the cell housing the liquid of interest functions as a capacitor element of the oscillator. The frequency of the generated oscillations is meticulously recorded using a seven-digit frequency meter with a resolution of 1 Hz. The cell was filled with an array of pure liquids with known dielectric constants, and their frequencies were subsequently recorded at ambient temperatures. An equation was fitted to the frequency–dielectric constant curve, which was used as a calibration equation to determine the dielectric constant of subsequent liquids. In addition to pure liquids, dielectric constants for solvent mixtures of varying mole fractions were also calculated using the previously established calibration equation. Our results demonstrated excellent frequency stability of the instrument, and the obtained dielectric constant values displayed significant consistency with both the experimental data and predictions made by computational methodologies. This suggests that the constructed instrument exhibits a high level of accuracy in measuring the dielectric constant of both pure and mixed liquids, establishing its potential utility in relevant research and industrial applications.