bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments
Authors: Payne Shelley M. , Mey Alexandra R. , Wyckoff Elizabeth E. 
Published: December 2015

SUMMARY

Iron is an essential element for
Vibrio
spp., but the acquisition of iron is complicated by its tendency to form insoluble ferric complexes in nature and its association with high-affinity iron-binding proteins in the host. Vibrios occupy a variety of different niches, and each of these niches presents particular challenges for acquiring sufficient iron.
Vibrio
species have evolved a wide array of iron transport systems that allow the bacteria to compete for this essential element in each of its habitats. These systems include the secretion and uptake of high-affinity iron-binding compounds (siderophores) as well as transport systems for iron bound to host complexes. Transporters for ferric and ferrous iron not complexed to siderophores are also common to
Vibrio
species. Some of the genes encoding these systems show evidence of horizontal transmission, and the ability to acquire and incorporate additional iron transport systems may have allowed
Vibrio
species to more rapidly adapt to new environmental niches. While too little iron prevents growth of the bacteria, too much can be lethal. The appropriate balance is maintained in vibrios through complex regulatory networks involving transcriptional repressors and activators and small RNAs (sRNAs) that act posttranscriptionally. Examination of the number and variety of iron transport systems found in
Vibrio
spp. offers insights into how this group of bacteria has adapted to such a wide range of habitats.
Effects of Acupuncture at Ht7 on Glucose Metabolism in a Rat Model of Alzheimer's Disease: An 18F-FDG-PET study
Authors: Lai Xinsheng , Ren Jie , Lu Yangjia , Cui Shaoyang , Chen Junqi , Huang Yong , Tang Chunzhi , Shan Baoci , Nie Bingbing 
Published: December 2015

Objective To explore the effects of acupuncture at HT7 on different cerebral regions in a rat model of Alzheimer's disease (AD) with the application of 18F-2-fluoro-deoxy-D-glucose positron emission tomography (FDG-PET). Methods Sixty Wistar rats were included after undergoing a Y-maze electric sensitivity test. Ten rats were used as a healthy control group. The remaining 50 rats were injected stereotaxically with ibotenic acid into the right nucleus basalis magnocellularis and injected intraperitoneally with D-galactose. AD was successfully modelled in 36 rats, which were randomly divided into three groups (n=12 each): the AD group, which remained untreated; the AD+HT7 group, which received 20 sessions of acupuncture at HT7 over 1 month; and the AD+Sham group, which received acupuncture at a distant non-acupuncture point. Total reaction time (TRT) was measured by Y-maze and 18F-FDG-PET scans were conducted on day 1 and 30. PET images were processed with Statistical Parametric Mapping 8.0. Results Pre-treatment, TRT was greater in all AD groups versus controls (mean±SD 24.10±2.48 vs 41.34±5.00 s). Post-treatment, TRT was shortened in AD+HT7 versus AD+Sham and AD groups (p<0.0001, two-way analysis of variance). Glucose metabolic activity in the hippocampus, thalamus, hypothalamus, frontal lobe, and temporal lobe was decreased in AD rats compared with healthy controls and relatively elevated after HT7 acupuncture. Compared with sham acupuncture, HT7 needling had a greater positive influence on brain glucose metabolism. Conclusions Needling at HT7 can improve memory ability and cerebral glucose metabolic activity of the hippocampus, thalamus, hypothalamus, and frontal/temporal lobes in an AD rat model.
Computerised versus conventional methodology of radiographic joint destruction assessment in early rheumatoid arthritis
Authors: Huo Yinghe , De Hair Maria J H , Shaib Yasmin O , van der Heijde Désirée , Kuchuk Natalia O , Viergever Max A , van Laar Jacob M , Vincken Koen L , Lafeber Floris P 
Published: December 2015

ObjectivesTo compare computerised and conventional methodology of radiographic joint destruction assessment in early rheumatoid arthritis (RA).MethodsWe investigated the contribution of the 3rd-to-5th carpometacarpal joints (CMC3-5, which are excluded in computerised assessment so far owing to bone overlapping) to total joint space narrowing (JSN) scores in two cohorts of patients with early RA (n=392). Next, we investigated agreement between JSN scoring using single time point individual joint-based method (individual joint of a single time point (IJSTP), reflecting computerised reading) and conventional JSN scoring using the Sharp-van der Heijde (SvdH) method in a cohort of patients with early RA (n=59). We used intraclass correlation coefficients (ICCs), Bland and Altman plots, and linear mixed modelling to analyse differences in progression between two methods. Radiographs were available at baseline, and at 1 and 2 years of follow-up.ResultsOf all joints affected by JSN at baseline or JSN progression during 2 years of follow-up, 3.9% and 6.6% concerned CMC3-5. Exclusion of CMC3-5 resulted in a decrease of 1.9–4.6% in JSN progression scores during 2 years of follow-up. The ICCs for JSN progression scores using IJSTP with or without CMC3-5 compared with SvdH were 0.71–0.81 and 0.69–0.78 at 1 and 2 years of follow-up. Signal-to-noise ratios for IJSTP-based and SvdH scoring were 0.51 and 0.58, respectively. The progression rate for each year was not statistically significantly different between two scoring methods (p=0.59 and 0.89).ConclusionsThis study showed that excluding CMC3-5 has limited influence on JSN (progression) scores and showed the feasibility of using IJSTP-based reading for computerised scoring of JSN (progression) in RA.
Diagnosability under Weak Fairness
Authors: Germanos Vasileios , Haar Stefan , Khomenko Victor , Schwoon Stefan 
Published: December 2015

In partially observed Petri nets, diagnosis is the task of detecting whether the given sequence of observed labels indicates that some unobservable fault has occurred. Diagnosability is an associated property of the Petri net, stating that in any possible execution, an occurrence of a fault can eventually be diagnosed.
In this article, we consider diagnosability under the weak fairness (WF) assumption, which intuitively states that no transition from a given set can stay enabled forever—it must eventually either fire or be disabled. We show that a previous approach to WF-diagnosability in the literature has a major flaw and present a corrected notion. Moreover, we present an efficient method for verifying WF-diagnosability based on a reduction to LTL-X model checking. An important advantage of this method is that the LTL-X formula is fixed—in particular, the WF assumption does not have to be expressed as a part of it (which would make the formula length proportional to the size of the specification), but rather the ability of existing model checkers to handle weak fairness directly is exploited.
Oxygen-Enhanced MRI Accurately Identifies, Quantifies, and Maps Tumor Hypoxia in Preclinical Cancer Models
Authors: O'Connor James P.B. , Boult Jessica K.R. , Jamin Yann , Babur Muhammad , Finegan Katherine G. , Williams Kaye J. , Little Ross A. , Jackson Alan , Parker Geoff J.M. , Reynolds Andrew R. , Waterton John C. , Robinson Simon P. 
Published: December 2015

Abstract
There is a clinical need for noninvasive biomarkers of tumor hypoxia for prognostic and predictive studies, radiotherapy planning, and therapy monitoring. Oxygen-enhanced MRI (OE-MRI) is an emerging imaging technique for quantifying the spatial distribution and extent of tumor oxygen delivery in vivo. In OE-MRI, the longitudinal relaxation rate of protons (ΔR1) changes in proportion to the concentration of molecular oxygen dissolved in plasma or interstitial tissue fluid. Therefore, well-oxygenated tissues show positive ΔR1. We hypothesized that the fraction of tumor tissue refractory to oxygen challenge (lack of positive ΔR1, termed “Oxy-R fraction”) would be a robust biomarker of hypoxia in models with varying vascular and hypoxic features. Here, we demonstrate that OE-MRI signals are accurate, precise, and sensitive to changes in tumor pO2 in highly vascular 786-0 renal cancer xenografts. Furthermore, we show that Oxy-R fraction can quantify the hypoxic fraction in multiple models with differing hypoxic and vascular phenotypes, when used in combination with measurements of tumor perfusion. Finally, Oxy-R fraction can detect dynamic changes in hypoxia induced by the vasomodulator agent hydralazine. In contrast, more conventional biomarkers of hypoxia (derived from blood oxygenation-level dependent MRI and dynamic contrast–enhanced MRI) did not relate to tumor hypoxia consistently. Our results show that the Oxy-R fraction accurately quantifies tumor hypoxia noninvasively and is immediately translatable to the clinic. Cancer Res; 76(4); 787–95. ©2015 AACR.
Integrative Analysis Reveals the Transcriptional Collaboration between EZH2 and E2F1 in the Regulation of Cancer-Related Gene Expression
Authors: Xu Han , Xu Kexin , He Housheng H. , Zang Chongzhi , Chen Chen-Hao , Chen Yiwen , Qin Qian , Wang Su , Wang Chenfei , Hu Shengen , Li Fugen , Long Henry , Brown Myles , Liu X. Shirley 
Published: December 2015

Abstract
Overexpression of EZH2 is frequently linked to the advanced and metastatic stage of cancers. The mechanisms of its oncogenic function can be context specific, and may vary depending on the protein complexes that EZH2 interacts with. To identify novel transcriptional collaborators of EZH2 in cancers, a computational approach was developed that integrates protein–DNA binding data, cell perturbation gene expression data, and compendiums of tumor expression profiles. This holistic approach identified E2F1, a known mediator of the Rb tumor suppressor, as a transcriptional collaborator of EZH2 in castration-resistant prostate cancer. Subsequent analysis and experimental validation found EZH2 and E2F1 cobind to a subset of chromatin sites lacking H3K27 trimethylation, and activate genes that are critical for prostate cancer progression. The collaboration of EZH2 and E2F1 in transcriptional regulation is also observed in diffuse large B-cell lymphoma cell lines, where activation of the transcriptional network is concordant with the cellular response to the EZH2 inhibitor.
Implications: The direct collaboration between EZH2 and Rb/E2F1 pathway provides an innovative mechanism underlying the cascade of tumor progression, and lays the foundation for the development of new anticancer targets/strategies. Mol Cancer Res; 14(2); 163–72. ©2015 AACR.
Probability of developing proximal deep-vein thrombosis and/or pulmonary embolism after distal deep-vein thrombosis
Authors: Patel Krishna , Chagin Kevin , Tunsupon Pichapong , Yampikulsakul Pojchawan , Shah Gautam V. , Wangsiricharoen Sintawat , Amah Linda , Allen Joshua , Shapiro Aryeh , Gupta Neha , Morgan Lillie , Kumar Rahul , Nielsen Craig , Rothberg Michael B. , Brateanu Andrei 
Published: December 2015

SummaryIsolated distal deep-vein thrombosis (DDVT) of the lower extremities can be associated with subsequent proximal deep-vein thrombosis (PDVT) and/or acute pulmonary embolism (PE). We aimed to develop a model predicting the probability of developing PDVT and/or PE within three months after an isolated episode of DDVT. We conducted a retrospective cohort study of patients with symptomatic DDVT confirmed by lower extremity vein ultrasounds between 2001–2012 in the Cleveland Clinic Health System. We reviewed all the ultrasounds, chest ventilation/perfusion and computed tomography scans ordered within three months after the initial DDVT to determine the incidence of PDVT and/or PE. A multiple logistic regression model was built to predict the rate of developing these complications. The final model included 450 patients with isolated DDVT. Within three months, 30 (7%) patients developed an episode of PDVT and/or PE. Only two factors predicted subsequent thromboembolic complications: inpatient status (OR, 6.38; 95 % CI, 2.17 to 18.78) and age (OR, 1.02 per year; 95 % CI, 0.99 to 1.05). The final model had a bootstrap bias-corrected c-statistic of 0.72 with a 95 % CI (0.64 to 0.79). Outpatients were at low risk (<4 %) of developing PDVT/PE. Inpatients aged ≥ 60 years were at high risk (> 10%). Inpatients aged < 60 were at intermediate risk. We created a simple model that can be used to risk stratify patients with isolated DDVT based on inpatient status and age. The model might be used to choose between anticoagulation and monitoring with serial ultrasounds.
De la séduction textile à la séduction textuelle dans Le Paysan parvenu et La Vie de Marianne de Marivaux
Authors: Guilhembet Jacques 
Published: December 2015

L’article évalue d’abord l’importance du textile dans le devenir des deux héros, Jacob et Marianne, et examine le pouvoir de séduction que leur offrent leurs nouveaux habits, sur eux-mêmes ou sur autrui. Une fois devenus narrateurs, c’est par l’écriture qu’ils tentent de créer une connivence avec leurs destinataires et de les influencer en leur faveur, en ornant, tissant ou brodant le canevas de leur existence. L’article analyse donc les principaux procédés rhétoriques utilisés par les deux narrateurs pour séduire le lecteur : l’affirmation de la spontanéité de l’écriture, le tissage du lien avec la narrataire, l’appel à l’émotion, l’autojustification, la mise en valeur de soi, la réécriture romanesque du passé, l’humour et l’autodérision.
Inducing Implicit Arguments from Comparable Texts: A Framework and Its Applications
Authors: Roth Michael , Frank Anette 
Published: December 2015

In this article, we investigate aspects of sentential meaning that are not expressed in local predicate–argument structures. In particular, we examine instances of semantic arguments that are only inferable from discourse context. The goal of this work is to automatically acquire and process such instances, which we also refer to as implicit arguments, to improve computational models of language. As contributions towards this goal, we establish an effective framework for the difficult task of inducing implicit arguments and their antecedents in discourse and empirically demonstrate the importance of modeling this phenomenon in discourse-level tasks. Our framework builds upon a novel projection approach that allows for the accurate detection of implicit arguments by aligning and comparing predicate–argument structures across pairs of comparable texts. As part of this framework, we develop a graph-based model for predicate alignment that significantly outperforms previous approaches. Based on such alignments, we show that implicit argument instances can be automatically induced and applied to improve a current model of linking implicit arguments in discourse. We further validate that decisions on argument realization, although being a subtle phenomenon most of the time, can considerably affect the perceived coherence of a text. Our experiments reveal that previous models of coherence are not able to predict this impact. Consequently, we develop a novel coherence model, which learns to accurately predict argument realization based on automatically aligned pairs of implicit and explicit arguments.
Worldwide Survey of Awareness and Needs Concerning Reanalyses and Respondents Views on Climate Services
Authors: Gregow H. , Jylhä K. , Mäkelä H. M. , Aalto J. , Manninen T. , Karlsson P. , Kaiser-Weiss A. K. , Kaspar F. , Poli P. , Tan D. G. H. , Obregon A. , Su Z. 
Published: December 2015

Abstract
A worldwide online survey about user awareness of reanalyses and climate services was conducted in the period from November 2013 to February 2014 by the Coordinating Earth Observation Data Validation for Re-Analysis for Climate Services (CORE-CLIMAX) project. The 2,578 respondents were mostly users of global reanalyses [particularly the European Centre for Medium-Range Weather Forecasts (ECMWF), National Centers for Environmental Prediction (NCEP), National Aeronautics and Space Administration (NASA), and Japan Meteorological Agency (JMA) reanalyses]. They answered queries arranged in 11 sections by choosing from preprepared check-box responses and left several hundred free comments. Here, we analyze responses related to characteristics of reanalysis data and the perceived obstacles for using reanalysis in climate services. After examining responses from all survey participants, we focus on the answers from subgroups working in specific disciplines related to natural resource management: freshwater, agriculture and food production, forestry, and energy. Although the survey attracted mostly self-selected respondents from the education and public research and development (R&D) sectors, one-third of the energy-related subgroup were from the private sector. A large majority (91%) of the respondents use ECMWF reanalyses, but other reanalysis products are also widely used by them. Respondents expressed desire for reanalysis development in the areas of 1) training and online plotting tools, 2) more frequent updates, 3) explanations about uncertainties (the energy subgroup emphasizes this), 4) smaller biases, 5) less restrictive data policy, and 6) higher temporal and spatial resolution (the energy and water subgroups highlight this). Additionally, the subgroups (excluding energy) expressed interest in including in future climate services activities for applied weather and climate research for impact assessment and/or statistical impact analyses for improving weather warnings and their criteria.
Numerical Study of the Daytime Planetary Boundary Layer over an Idealized Urban Area: Influence of Surface Properties, Anthropogenic Heat Flux, and Geostrophic Wind Intensity
Authors: Falasca Serena , Catalano Franco , Moroni Monica 
Published: December 2015

AbstractLarge-eddy simulations of an idealized diurnal urban heat island are performed using the Weather Research and Forecasting Model. The surface energy balance over an inhomogeneous terrain is solved considering the anthropogenic heat contribution and the differences of thermal and mechanical properties between urban and rural surfaces. Several cases are simulated together with a reference case, considering different values of the control parameters: albedo, thermal inertia, roughness length, anthropogenic heat emission, and geostrophic wind intensity. Spatial distributions of second-moment statistics, including the turbulent kinetic energy (TKE) budget, are analyzed to characterize the structure of the planetary boundary layer (PBL). The effect of each control parameter value on the turbulent properties of the PBL is investigated with respect to the reference case. For all of the analyzed cases, the primary source of TKE is the buoyancy in the lower half of the PBL, the shear in the upper half, and the turbulent transport term at the top. The vertical advection of TKE is significant in the upper half of the PBL. The control parameters significantly influence the shape of the profiles of the transport and shear terms in the TKE budget. Bulk properties of the PBL via proper scaling are compared with literature data. A log-linear relationship between the aspect ratio of the heat island and the Froude number is confirmed. For the first time, the effect of relevant surface control parameters and the geostrophic wind intensity on the bulk and turbulent properties of the PBL is systematically investigated at high resolution.
Temperature and Precipitation Extremes in the United States: Quantifying the Responses to Anthropogenic Aerosols and Greenhouse Gases,+
Authors: Mascioli Nora R. , Fiore Arlene M. , Previdi Michael , Correa Gustavo 
Published: December 2015

Abstract
Changes in extreme temperatures, heat waves, and heavy rainfall events have adverse effects on human health, air quality, and water resources. With aerosol-only (AER) and greenhouse gas–only (GHG) simulations from 1860 to 2005 in the GFDL CM3 chemistry–climate model, aerosol-induced versus greenhouse gas–induced changes in temperature (summer) and precipitation (all seasons) extremes over the United States are investigated. Small changes in these extremes in the all forcing simulations reflect cancellations between the effects of increasing anthropogenic aerosols and greenhouse gases. In AER, extreme high temperatures and the number of days with temperatures above the 90th percentile decline over most of the United States. The strongest response occurs in the western United States (−2.0°C and −14 days, regionally averaged) and the weakest response occurs in the southeastern United States (−0.6°C and −4.8 days). An opposite-signed response pattern occurs in GHG (+2.3°C and +11.5 days over the western United States and +1.6°C and +7.2 days over the southeastern United States). The similar spatial response patterns in AER versus GHG suggest a preferred regional mode of response that is largely independent of the type of forcing. Extreme precipitation over the eastern United States decreases in AER, particularly in winter, and increases over the eastern and central United States in GHG, particularly in spring. Over the twenty-first century under the representative concentration pathway 8.5 (RCP8.5) emissions scenario, the patterns of extreme temperature and precipitation associated with greenhouse gas forcing dominate.
Early toxic epidermal necrolysis syndrome post-intra-cranial tumor resection
Authors: Ramachandren Thavenesh K , Petrilli Renée MA 
Published: December 2015

Introduction SJS and TEN are two rare self-limited but serious cutaneous drug reactions with significant morbidity and mortality. There are many drugs associated with the condition. We report a case of early TEN syndrome post Carbamazepine use, review the current literature and discuss the management challenges. Case Report A 51-year-old female was admitted to hospital for investigation and management of complex partial seizures secondary to a meningioma. She was commenced on 100mg BD of Carbamazepine for seizure control and discharged home. Surgical resection of the meningioma was performed electively 2 weeks later. A localized erythematous macular rash mainly in the left shoulder was noted on postoperative day 3. Two days later, the patient had sloughing of the mucosa of the lips in addition to progression of the rash. Early Toxic Epidermal Necrolysis (TEN) syndrome was diagnosed by the Burns and Dermatology teams and the culprit drug was discontinued. Skin biopsy confirmed the diagnosis. The patient was commenced on intravenous immunoglobulins with excellent improvement in skin integrity and resolution of excoriations noted on discharge. Discussion Stevens - Johnson syndrome (SJS) and TEN are two rare self-limited but serious cutaneous drug reactions with significant morbidity and mortality. The current treatment of TENS/SJS is divided into early management and symptom control. The immediate cessation of the culprit drug is quintessential. There is vast documented evidence of carbamazepine- induced SJS/TEN in patients of Asian ethnicity due to the presence of the HLA allele B*1502. HLA-B*1502 screening should be performed when using aromatic anticonvulsants such as carbamazepine in high-risk patients.