bluuebunny/crossref_metadata_2025_split huggingface dataset:
A propensity score matched comparative study between paclitaxel‐coated balloon and everolimus‐eluting stents for the treatment of small coronary vessels
Authors: Giannini Francesco , Latib Azeem , Ancona Marco B. , Costopoulos Charis , Ruparelia Neil , Menozzi Alberto , Castriota Fausto , Micari Antonio , Cremonesi Alberto , De Felice Francesco , Marchese Alfredo , Tespili Maurizio , Presbitero Patrizia , Sgueglia Gregory A. , Buffoli Francesca , Tamburino Corrado , Varbella Ferdinando , Colombo Antonio 
Published: January 2017

ObjectivesTo compare the long‐term clinical outcomes of paclitaxel drug‐coated‐balloons (DCB) and everolimus‐eluting‐stents (EES) following the treatment of de novo small vessel coronary artery disease.BackgroundIt is currently unclear whether treatment of de novo small vessel coronary disease with DCB is comparable to second generation drug‐eluting stents, which are the current standard of care.MethodsThe present study enrolled 90 patients with small vessel coronary disease from the DCB treatment arm of the BELLO (Balloon Elution and Late Loss Optimization) trial and 2,000 patients treated with EES at the San Raffaele Scientific Institute. Propensity score matching was performed to adjust for differences in baseline clinical and angiographic characteristics, yielding a total of 181 patients: 90 patients with 94 lesions receiving DCB and 91 patients with 94 lesions receiving EES. Major adverse cardiac events (MACE) were defined as the composite of cardiac death, recurrent non‐fatal myocardial infarction, and target vessel revascularization.ResultsAfter propensity score matching, baseline clinical and angiographic characteristics were similar between the two groups. The cumulative MACE rate at 1‐year was 12.2% with DCB and 15.4% with EES (P = 0.538). Patients in the DCB group had similar TLR rates as compared to EES over the same interval (4.4% vs. 5.6%; P = 0.720). There were no cases of definite or probable stent or vessel thrombosis.ConclusionsThe use of paclitaxel‐DCB appears to be associated with similar clinical outcomes when compared to second‐generation‐EES in small coronary artery disease. The findings of this study should be confirmed with larger prospective randomized studies with longer follow‐up. © 2017 Wiley Periodicals, Inc.
Prolonged QT interval and cardiac arrest after a single dose of amiodarone in a woman with Turner's syndrome
Authors: Nielsen Dorte Guldbrand , Nielsen Jens Cosedis , Trolle Christian , Gravholt Claus Højbjerg , Andersen Niels Holmark 
Published: January 2017

Key Clinical MessageLow‐dose QT‐prolonging drugs may have detrimental effects on women with Turner's syndrome. Preventive measures would be to use potential QT‐prolonging drugs with precaution and ensure that both before and during treatment, ECGs are evaluated and drug treatment stopped if the QT interval increases.
Synthesis and Characterization of Three‐Dimensional Porous Cu@Pt and Cu@Pt‐Ru Catalysts for Methanol Oxidation
Authors: Alvarez Andrea E. , Sieben Juan Manuel , Duarte Marta M. E. 
Published: January 2017

AbstractHighly porous Cu foams comprised of interconnected branched dendrites were used as sacrificial templates for the fabrication of pseudo core–shell Cu@Pt and Cu@Pt‐Ru unsupported electrodes by galvanic replacement. The as‐prepared materials presented a three‐dimensional structure with pores between 17 and 45 μm made of superimposed layers of ramified dendrites. TEM analysis showed that the dendrites were composed of agglomerates of grains of about 4 nm in size and mesopores of ca. 30 nm in diameter. The as‐prepared 3D electrodes were tested for methanol oxidation in acid media at different temperatures. The results showed that the catalytic activities of Cu@Pt and Cu@Pt‐Ru foams normalized to the electrochemical surface area are almost 50 % higher than that of a commercial Pt−Ru/C material, with poisoning rates that are reduced by half in the same potential range. The enhanced behavior of the as‐prepared foams is believed to be the result of the influence of copper atoms on the reactivity of platinum sites, the highly defective structure of the electrodes, as well as the facilitated diffusion of methanol molecules and the products formed during the reaction throughout the highly porous three‐dimensional structure of the electrode. The apparent activation energies (Ea,app) for the methanol oxidation reaction (MOR) were determined by potentiostatic experiments. Ea,app values of 29.07 and 24.20 kJ mol−1 were calculated for Cu@Pt and Cu@Pt‐Ru foams at 0.3 V, respectively. The results suggested that the MOR is governed by the dissociative adsorption of methanol as a result of the multifunctional nature of the catalyst and the facilitated diffusion of the products formed during the reaction.
Highly Active Noble‐Metal‐Free Copper Hydroxyapatite Catalysts for the Total Oxidation of Toluene
Authors: Chlala Dayan , Giraudon Jean‐Marc , Nuns Nicolas , Labaki Madona , Lamonier Jean‐François 
Published: January 2017

AbstractHydroxyapatite (Hap) supported Cu materials prepared by the wet impregnation method were designed as noble‐metal‐free catalysts for the total oxidation of toluene. Cu/Hap materials with different Cu loadings (2.5–20 wt %) calcined at 400 °C were characterized by using inductively coupled plasma optical emission spectroscopy, N2 physisorption, XRD, Raman spectroscopy, IR spectroscopy, X‐ray photoelectron spectroscopy, and time‐of‐flight secondary ion MS. The tenorite CuO phase was detected in all materials, and the libethenite Cu2(PO4)OH phase was observed for the sample with 20 wt % Cu. The presence of libethenite was accompanied by the formation of Ca2CO3H+ ions at the Hap surface. Residual NO3− species that interact with Cu and Ca were also found, and their amount increased with the increase of the Cu content in the sample. Interestingly, the specific activity in the total oxidation of toluene increased with the decrease of the Cu content in the catalyst. The rate per mole of Cu was increased by 10 times if the Cu content was decreased by four times. This noticeable result could be related to the presence of acid sites with a moderate strength as well as finely dispersed CuO species on the Hap, which allow the activation of toluene molecules and their oxidation through a redox mechanism. Moreover, Cu2.5 wt %/Hap showed a remarkably stable catalytic performance for 45 h time‐on‐stream, which evidences that this material has a high potential for applications in the removal of volatile organic compounds.
Effects of Charge Transfer on the Adsorption of CO on Small Molybdenum‐Doped Platinum Clusters
Authors: Ferrari Piero , Vanbuel Jan , Tam Nguyen Minh , Nguyen Minh Tho , Gewinner Sandy , Schöllkopf Wieland , Fielicke André , Janssens Ewald 
Published: January 2017

AbstractThe interaction of carbon monoxide with platinum alloy nanoparticles is an important problem in the context of fuel cell catalysis. In this work, molybdenum‐doped platinum clusters have been studied in the gas phase to obtain a better understanding of the fundamental nature of the Pt–CO interaction in the presence of a dopant atom. For this purpose, Ptn+ and MoPtn−1+ (n=3–7) clusters were studied by combined mass spectrometry and density functional theory calculations, making it possible to investigate the effects of molybdenum doping on the reactivity of platinum clusters with CO. In addition, IR photodissociation spectroscopy was used to measure the stretching frequency of CO molecules adsorbed on Ptn+ and MoPtn−1+ (n=3–14), allowing an investigation of dopant‐induced charge redistribution within the clusters. This electronic charge transfer is correlated with the observed changes in reactivity.
Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5‐O‐Monoprotected or 5‐Modified Ribose: Improved Protocol, Scope, and Mechanism
Authors: Downey A. Michael , Pohl Radek , Roithová Jana , Hocek Michal 
Published: January 2017

AbstractSimplifying access to synthetic nucleosides is of interest due to their widespread use as biochemical or anticancer and antiviral agents. Herein, a direct stereoselective method to access an expansive range of both natural and synthetic nucleosides up to a gram scale, through direct glycosylation of nucleobases with 5‐O‐tritylribose and other C5‐modified ribose derivatives, is discussed in detail. The reaction proceeds through nucleophilic epoxide ring opening of an in situ formed 1,2‐anhydrosugar (termed “anhydrose”) under modified Mitsunobu reaction conditions. The scope of the reaction in the synthesis of diverse nucleosides and other 1‐substituted riboside derivatives is described. In addition, a mechanistic insight into the formation of this key glycosyl donor intermediate is provided.
Triazole‐Based Anion‐Binding Catalysis for the Enantioselective Dearomatization of N‐Heteroarenes with Phosphorus Nucleophiles
Authors: Fischer Theresa , Duong Qui‐Nhi , García Mancheño Olga 
Published: January 2017

AbstractThe first enantioselective synthesis of chiral heterocyclic α‐amino phosphonates by nucleophilic dearomatization of quinolines and pyridines using an anion‐binding organocatalysis approach is described. Chiral tetrakistriazoles were employed as efficient hydrogen‐bond donor catalysts by forming a chiral close ion‐pair with the in situ formed N‐acyl salts and 2,2,2‐trichlorethoxycarbonyl chloride (TrocCl). The ion‐pair was subsequently treated with various phosphorus nucleophiles, such as silyl‐protected dialkyl‐ and trialkylphosphites. Thus, the corresponding products were obtained in complete or high regioselectivities and up to 97:3 e.r. for quinolines or up to 89:11 e.r. for the more challenging pyridine substrates. This method allows for rapid access to substituted chiral cyclic α‐amino phosphonates, which can be easily transformed into phosphonic acid derivatives.
Modelling, simulation, and membrane wetting estimation in gas‐liquid contacting processes
Authors: Pantoleontos Grigorios , Theodoridis Theodoros , Mavroudi Maria , Kikkinides Eustathios S. , Koutsonikolas Dimitrios , Kaldis Sotirios P. , Pagana Adamantia E. 
Published: January 2017

AbstractA set of experiments for CO2 separation from CO2‐N2 mixture by absorption into water by means of a gas‐liquid membrane contacting process is modelled using the mass continuity equation by combining process conditions, membrane and fluids properties, and module geometric characteristics. The general case of non‐constant concentration of the diffusing component in the shell side (Case B) is used, which entails an integro‐differential boundary condition at the lumen‐wall. The computational method is compared with existing literature data in terms of the logarithmic averaged overall and lumen Sherwood numbers revalidating the superiority of the counter‐current to the co‐current mode of operation, while offering a theoretical prediction of the limited behaviour of the latter as a function of the equilibrium coefficient. The elaborate model is then applied in order to assess the extent of membrane wetting due to liquid penetration into the pores in terms of the resistance‐in‐series model by comparing with the experimental results derived in a commercial cross‐flow membrane module under the counter‐current mode of operation. It is revealed that the assumption of shell‐side constant concentration (Case A) underestimates the wetting leading to a false estimation of the extent of liquid penetration into membrane pores. For Case B, a wetting‐pattern appears showing a correlation of an increasing shell‐side liquid flow rate with a decreasing wetting parameter and, thus, relatively less contribution of the liquid‐filled membrane resistance to the overall membrane resistance with increasing liquid loading.
Effect of nitrogen doping on the catalytic activity of activated carbon and distribution of oxidation products in catalytic wet oxidation of phenol
Authors: Yang Guo , Chen Honglin , Qin Hangdao , Zhang Xiaoming , Feng Yujun 
Published: January 2017

AbstractNitrogen‐containing functional groups were introduced into activated carbon (AC) by amination at high temperatures to investigate their effects on the catalytic activity and distribution of products in the catalytic wet air oxidation (CWAO) of phenol at 120 and 160 °C. The results show that the catalytic activity of the nitrogen‐doped AC increases with amination temperature from 250 to 850 °C. The linear relationship between the quantity of nitrogen‐containing functional groups and the catalytic activity indicates that the enhanced activities are closely related to the amount of pyridinic and pyrrolic nitrogen groups on the surface of the AC. The parent and aminated AC exhibit distinct distributions of oxidation products. Oxalic acid is favourably degraded on the aminated AC, whereas the all‐carbon AC shows a similar ability for the removal of acetic acid.
A NEW METHOD FOR DROUGHT MONITORING BASED ON LAND SURFACE ENERGY BALANCE AND ITS PRELIMINARY APPLICATION TO THE HEDONG REGION OF GANSU PROVINCE
Authors: Xiao‐Cui HAO , Qiang ZHANG , Ze‐Su YANG , Xiao‐Wei WANG , Ping YUE , Tao HAN , Sheng WANG 
Published: January 2017

AbstractCurrent drought monitoring methods based on remote sensing technique generally are not of high precision. Seeking a new remote sensing drought monitoring technique is of great help to improve and develop the technique of drought monitoring and alert. The Bowen ratio, the ratio of sensible heat flux against latent heat flux, and reflecting surface hydro‐thermal characteristics can be tentatively utilized for drought monitoring. Using EOS‐MODIS satellite data and synchronized meteorological data, the Bowen ratio drought monitoring model was established based on surface energy balance. Then, the correlation between soil moisture against Bowen ratio index (β) and temperature‐vegetation index (TVX) was analyzed. Finally, taking the clear‐sky imagery (October 5, 2014) as an example, a drought level classification standard based on β was established and droughts in the study region were evaluated. Results show that β is highly negatively related to soil relative humidity, which has a better correlation than that between TVX and soil relative humidity in the depth range of 0∼20 cm. The precision of drought monitoring is significantly improved. The distribution of dry‐wet condition based on the β drought classification standard is well consistent with the distribution of antecedent precipitation over the study region. Evaluation results show that generally no drought took place over the study region on October 5, 2014, which is consistent with precipitation anomaly percentage for the period of September, 2014. Our study suggests that the surface energy balance based Bowen ratio index can achieve excellent results when applied to drought monitoring and has a good application prospect.
Controlled Generation of Ultrathin‐Shell Double Emulsions and Studies on Their Stability
Authors: Zhao Chun‐Xia , Chen Dong , Hui Yue , Weitz David A. , Middelberg Anton P. J. 
Published: January 2017

AbstractDouble emulsions with a hierarchical core–shell structure have great potential in various applications, but their broad use is limited by their instability. To improve stability, water‐in‐oil‐in‐water (W/O/W) emulsions with an ultrathin oil layer of several hundred nanometres were produced by using a microcapillary device. The effects of various parameters on the generation of ultrathin‐shell double emulsions and their droplet size were investigated, including the proper combinations of inner, middle and outer phases, flow rates and surfactants. The surfactant in the middle oil phase was found to be critical for the formation of the ultrathin‐shell double emulsions. Furthermore, the stability of these double emulsions can be notably improved by increasing the concentration of the surfactant, and they can be stable for months. This opens up new opportunities for their future applications in cosmetics, foods and pharmaceuticals.
Composite mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Sun Yi , Wang Sa A. , Sun Tsieh 
Published: January 2017

BackgroundComposite mantle cell lymphoma (MCL) and chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is rare, as less than 20 cases have been reported so far. However, this entity may be under‐diagnosed because the two lymphomas are very similar in morphology and immunophenotype. Previous cases were mostly diagnosed with immunohistochemistry, but flow cytometry may play an important role in the detection of two tumors in the same specimen, thus achieving an accurate diagnosis. By definition, a composite lymphoma is two demarcated lymphomas occurring at the same anatomic site. Therefore, immunohistochemistry is still needed to identify the topographic relation of these two tumors. Our reported case illustrates the pitfalls in the diagnostic process and we recommend two standard panels with new markers for an accurate diagnosis of this composite lymphoma.MethodFACSCanto II is used with antibodies, including CD5, CD10, CD19, CD20, CD22, CD23, CD43, CD79b, CD200, kappa, and lambda. Immunohistochemical stains include PAX‐5/CD5 dual stain, Cyclin D1, SOX11, and LEF‐1.ResultsCLL/SLL is positive for CD5, CD19, CD23, CD43, and CD200, with dim expression of CD20, CD22, CD79b, and kappa. MCL is positive for CD5, CD19, CD20, CD22, CD79b, kappa, and negative for CD23, CD43, and CD200. Immunohistochemical stains show that PAX‐5/CD5 stains the entire tumor population. Cyclin D1 and SOX11 only stain the central portion that represents MCL and LEF‐1 stains the periphery that represents CLL/SLL.ConclusionsWe recommend the use of the above panels for flow cytometry and immunohistochemistry, respectively. LEF‐1 is specific for CLL/SLL; and CD200 is helpful to distinguish CLL/SLL from MCL. © 2017 International Clinical Cytometry Society
Assessing the hydroxyl radical and volatilization roles in aquatic fate estimations of sulfur heterocycles: Dibenzothiophene derivatives
Authors: Saranjampour Parichehr , Armbrust Kevin L. , Marx Brian D. 
Published: January 2017

Abstract

Polycyclic aromatic sulfur heterocycles (PASHs) and their alkyl derivatives can be released into aquatic systems via crude oil spills or runoff from petroleum-treated areas, such as asphalt. Dibenzothiophene (DBT) and its derivatives (C1-DBT, C2-DBT, and C4-DBT) were chosen as model compounds to investigate the relative impact of volatilization and hydroxyl radical degradation on estimates of their overall dissipation after entry into aquatic ecosystems as a function of depth using the exposure analysis modeling system (EXAMS). The hydroxyl radical rate constant (K · OH) and Henry's law constant of PASHs were determined in distilled water. The analogue C1-DBT reacted fastest with · OH relative to other PASHs. The C2-DBT and C4-DBT analogues had higher Henry's law constants compared with other derivatives. Steric hindrance by alkyl substituents on the sulfur moiety most strongly impacted measured rate and Henry's law constants between DBT and individual alkyl derivatives. These steric effects do not appear to be considered in the physical property estimation software EPI Suite. Simulated dissipation of PASHs using EXAMS suggests that volatilization is a dominant fate pathway for the higher molecular weight and less polar C2-DBT and C4-DBT at all depths and DBT and C1-DBT at 0.1-m. However, model scenarios suggest that hydroxyl radical degradation may significantly contribute to the degradation of more polar DBT and C1-DBT at 1-m and 2-m depths. Environ Toxicol Chem 2017;36:1998–2004. © 2017 SETAC
Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish
Authors: Yang Ye , Ji Dapeng , Huang Xin , Zhang Jianyun , Liu Jing 
Published: January 2017

Abstract

Co-occurrence of pyrethroids and metals in watersheds previously has been reported to pose great risk to aquatic species. Pyrethroids are a class of chiral insecticides that have been shown to have enantioselective toxicity and biotransformation. However, the influence of metals on enantioselectivity of pyrethroids has not yet been evaluated. In the present study, the effects of cadmium (Cd), copper (Cu), and lead (Pb) on the enantioselective toxicity and metabolism of cis-bifenthrin (cis-BF) were investigated in zebrafish at environmentally relevant concentrations. The addition of Cd, Cu, or Pb significantly increased the mortality of zebrafish in racemate and R-enantiomer of cis-BF–treated groups. In rac-cis-BF– or 1R-cis-BF–treated groups, the addition of Cd, Cu, or Pb caused a decrease in enantiomeric fraction (EF) and an increased ratio of R-enantiomer residues in zebrafish. In 1S-cis-BF–treated groups, coexposure to Cd led to a lower EF and decreased residue levels of S-enantiomer. In addition, coexposure to the 3 metals resulted in different biodegradation characteristics of each enantiomer accompanied with differential changes in the expression of cytochrome P450 (CYP)1, CYP2, and CYP3 genes, which might be responsible for the enantioselective biodegradation of cis-BF in zebrafish. These results suggest that the influence of coexistent metals should be considered in the ecological risk assessment of chiral pyrethroids in aquatic environments. Environ Toxicol Chem 2017;36:2139–2146. © 2017 SETAC
Thermo‐hydrodynamic‐mechanical multiphase flow model for CO2 sequestration in fracturing porous media
Authors: Arzanfudi Mehdi Musivand , Al‐Khoury Rafid 
Published: January 2017

AbstractIn this paper, we introduce a fully coupled thermo‐hydrodynamic‐mechanical computational model for multiphase flow in a deformable porous solid, exhibiting crack propagation due to fluid dynamics, with focus on CO2 geosequestration. The geometry is described by a matrix domain, a fracture domain, and a matrix‐fracture domain. The fluid flow in the matrix domain is governed by Darcy's law and that in the crack is governed by the Navier–Stokes equations. At the matrix‐fracture domain, the fluid flow is governed by a leakage term derived from Darcy's law. Upon crack propagation, the conservation of mass and energy of the crack fluid is constrained by the isentropic process. We utilize the representative elementary volume‐averaging theory to formulate the mathematical model of the porous matrix, and the drift flux model to formulate the fluid dynamics in the fracture. The numerical solution is conducted using a mixed finite element discretization scheme. The standard Galerkin finite element method is utilized to discretize the diffusive dominant field equations, and the extended finite element method is utilized to discretize the crack propagation, and the fluid leakage at the boundaries between layers of different physical properties. A numerical example is given to demonstrate the computational capability of the model. It shows that the model, despite the relatively large number of degrees of freedom of different physical nature per node, is computationally efficient, and geometry and effectively mesh independent. Copyright © 2017 John Wiley & Sons, Ltd.