bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemorrhagic Reversible Cerebral Vasoconstriction Syndrome
Authors: Topcuoglu Mehmet A. , Singhal Aneesh B. 
Published: June 2016

Background and Purpose—
To compare hemorrhagic and nonhemorrhagic reversible cerebral vasoconstriction syndromes (RCVS) with a view to understand mechanisms.

Methods—
This single-center retrospective study included 162 patients with RCVS. Clinical, brain imaging, and angiography data were analyzed.

Results—

The mean age was 44±13 years, 78% women. Hemorrhages occurred in 43% including 21 patients with intracerebral hemorrhage (ICH) and 62 with convexal subarachnoid hemorrhage (cSAH). The frequency of triggers (eg, vasoconstrictive drugs) and risk factors (eg, migraine) were not significantly different between hemorrhagic and nonhemorrhagic RCVS or between subgroups (ICH versus non-ICH, isolated cSAH versus normal scan). Hemorrhagic lesions occurred within the first week, whereas infarcts and vasogenic edema accumulated during 2 to 3 weeks (
P
<0.001). Although all ICHs occurred before cSAH, their time course was not significantly different (
P
=0.11). ICH and cSAH occurred earlier than infarcts (
P
≤0.001), and ICH earlier than vasogenic edema (
P
=0.009). Angiogram analysis showed more severe vasoconstriction in distal versus proximal segments in all lesion types (ICH, cSAH, infarction, vasogenic edema, and normal scan). The isolated infarction group had more severe proximal vasoconstriction, and those with normal imaging had significantly less vasoconstriction. Multivariable analysis failed to uncover independent predictors of hemorrhagic RCVS; however, female sex predicted ICH (
P
=0.048), and angiographic severity predicted infarction (
P
=0.043).

Conclusions—
ICH and cSAH are common complications of RCVS. Triggers and risk factors do not predict lesion subtype but may alter central vasomotor control mechanisms resulting in centripetal angiographic evolution. Early distal vasoconstriction is associated with lobar ICH and cSAH, and delayed proximal vasoconstriction with infarction.
Eleocharis pedrovianae, a new species of Cyperaceae from Northern Brazil (Serra dos Carajás, Pará State)
Authors: NUNES CLEBIANA DE SÁ , GIL ANDRÉ DOS SANTOS BRAGANÇA , TREVISAN RAFAEL 
Published: June 2016

Eleocharis pedrovianae is a new species of Cyperaceae from the Serra dos Carajás (Pará State, Brazil), herein described and illustrated. This species lives as a submerged herb in wetlands, marshes and margins of temporary lakes and lagoons with ferric soil (canga). It is morphologically similar to Eleocharis angustispicula, differing by its stoloniferous stem system, the presence of chasmogamous basal spikelets, a perianth of 4(5) bristles, an ellipsoid achene, and a stylopodium that is brown pyramidal, and separated from the achene body by a constriction.
Fidelity to a behavioral intervention to improve goals of care decisions for nursing home residents with advanced dementia
Authors: Hanson Laura C , Song Mi-Kyung , Zimmerman Sheryl , Gilliam Robin , Rosemond Cherie , Chisholm Latarsha , Lin Feng-Chang 
Published: June 2016

Background/aims: Ensuring fidelity to a behavioral intervention implemented in nursing homes requires awareness of the unique considerations of this setting for research. The purpose of this article is to describe the goals of care cluster-randomized trial and the methods used to monitor and promote fidelity to a goals of care decision aid intervention delivered in nursing homes. Methods: The cluster randomized trial tested whether a decision aid for goals of care in advanced dementia could improve (1) the quality of communication and decision-making, (2) the quality of palliative care, and (3) the quality of dying for nursing home residents with advanced dementia. In 11 intervention nursing homes, family decision-makers for residents with advanced dementia received a two-component intervention: viewing a video decision aid about goals of care choices and then participating in a structured decision-making discussion with the nursing home care plan team, ideally within 3 months after the decision aid was viewed. Following guidelines from the National Institutes of Health Behavior Change Consortium, fidelity was assessed in study design, in nursing home staff training for intervention implementation, and in monitoring and receipt of the intervention. We also monitored the content and timing of goals of care discussions. Results: Investigators enrolled 151 family decision-maker/resident dyads in intervention sites; of those, 136 (90%) received both components of the intervention, and 92%–99% of discussions addressed each of four recommended content areas—health status, goals of care, choice of a goal, and treatment planning. A total of 94 (69%) of the discussions between family decision-makers and the nursing home care team were completed within 3 months. Conclusion: The methods we used for intervention fidelity allowed nursing home staff to implement a goals of care decision aid intervention for advanced dementia. Key supports for implementation included design features that aligned with nursing home practice, efficient staff training, and a structured guide for goals of care discussions between family decision-makers and staff. These approaches may be used to promote fidelity to behavioral interventions in future clinical trials.
Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance
Authors: Guo Qiuyan , Mao Xia , Zhang Yanqiong , Meng Shuqin , Xi Yue , Ding Yi , Zhang Xiaocun , Dai Yuntao , Liu Xia , Wang Chao , Li Yuting , Lin Na 
Published: June 2016

AbstractBackgroundGuizhi-Shaoyao-Zhimu decoction (GSZD) has been extensively used for rheumatoid arthritis (RA) therapy. Marked therapeutic efficacy of GSZD acting on RA has been demonstrated in several long-term clinical trials without any significant side effects. However, its pharmacological mechanisms remain unclear due to a lack of appropriate scientific methodology.MethodsGSZD’s mechanisms of action were investigated using an integrative approach that combined drug target prediction, network analysis, and experimental validation.ResultsA total of 77 putative targets were identified for 165 assessed chemical components of GSZD. After calculating the topological features of the nodes and edges in the created drug-target network, we identified a candidate GSZD-targeted signal axis that contained interactions between two putative GSZD targets [histone deacetylase 1 (HDAC1) and heat shock protein 90 kDa alpha, class A member 1 (HSP90AA1)] and three known RA-related targets [NFKB2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB); and tumor necrosis factor-alpha (TNF-α)]. This signal axis could connect different functional modules that are significantly associated with various RA-related signaling pathways, including T/B cell receptor, Toll-like receptor, NF-kappa B and TNF pathways, as well as osteoclast differentiation. Furthermore, the therapeutic effects and putative molecular mechanisms of GSZD’s actions on RA were experimentally validated in vitro and in vivo.ConclusionsGSZD may partially attenuate RA by reversing inflammation-immune system imbalance and regulating the HDAC1–HSP90AA1–NFKB2–IKBKB–TNF-α signaling axis.
Mixed-Integer Rounding Enhanced Benders Decomposition for Multiclass Service-System Staffing and Scheduling with Arrival Rate Uncertainty
Authors: Bodur Merve , Luedtke James R. 
Published: June 2016

We study server scheduling in multiclass service systems under uncertainty in the customer arrival volumes. Common practice in such systems is to first identify staffing levels and then determine schedules for the servers that cover these levels. We propose a new stochastic integer programming (SIP) model that integrates these two decisions, which can yield lower scheduling costs by exploiting the presence of alternative server configurations that yield similar quality of service. We find that a branch-and-cut algorithm based on Benders decomposition may fail due to the weakness of the relaxation bound. We propose a novel application of mixed-integer rounding to improve the Benders cuts used in this algorithm, a technique that is applicable to any SIP with integer first-stage decision variables. Numerical examples illustrate the computational efficiency of the proposed approach and the potential benefit of solving the integrated model compared to considering the staffing and scheduling problems separately. This paper was accepted by Yinyu Ye, optimization.
Appendiceal mucocoele with midgut malrotation
Authors: Yap D , Hassall J , Williams GL , McKain ES 
Published: June 2016

Introduction Malrotation of the midgut and appendiceal mucocoele are both extremely rare pathological conditions in adults. To our knowledge, there are only two reported cases in the English literature with a combination of both conditions. Case History A 65-year-old man presented with a 10-day history of upper abdominal pain associated with abdominal bloating and weight loss. He was otherwise fit and healthy with no significant past medical history. On examination, his abdomen was soft with tenderness and palpable fullness over the left upper quadrant. The initial blood test, chest x-ray and abdominal x-ray demonstrated no significant abnormality. Computed tomography showed a 17cm x 8cm x 6cm elongated cystic mass with possible malrotation of the intestines. Histopathology showed a low grade mucinous tumour of the appendix. At 12 months following surgery, there was no evidence of recurrence or postoperative complications and the patient was discharged from the care of the colorectal team. Conclusions We report a patient with a combination of two rare conditions. This case illustrates how a combination of pathologies can present a challenge to the unwary general surgeon.
Type 4 appendiceal diverticulum within a de Garengeot hernia
Authors: Rossi SH , Coveney E 
Published: June 2016

A de Garengeot hernia is defined as an incarcerated femoral hernia containing the vermiform appendix. We describe the case of a patient with a type 4 appendiceal diverticulum within a de Garengeot hernia and delineate valuable learning points. A 76-year-old woman presented with a 2-week history of a non-reducible painless femoral mass. Outpatient ultrasonography demonstrated a 36mm × 20mm smooth walled, multiloculated, partially cystic lesion anterior to the right inguinal ligament in keeping with an incarcerated femoral hernia. Intraoperatively, the appendix was found to be incarcerated in the sac of the femoral hernia and appendicectomy was performed. Histopathology demonstrated no evidence of inflammation in the appendix. However, an incidental appendiceal diverticulum was identified. It is widely recognised that a de Garengeot hernia may present with concomitant appendicitis, secondary to raised intraluminal pressure in the incarcerated appendix. Appendiceal diverticulosis is also believed to develop in response to raised pressure in the appendix and may therefore develop secondary to incarceration in a de Garengeot hernia. To our knowledge, only one such case has been described in the literature. A de Garengeot hernia is a rare entity, which poses significant diagnostic challenges. A high index of clinical suspicion is necessary as these hernias are at particularly high risk of perforation and so prompt surgical management is paramount.
Numerical Approximation of Multi-Phase Penrose–Fife Systems
Authors: Gräser Carsten , Kahnt Max , Kornhuber Ralf 
Published: June 2016

Abstract
We consider a non-isothermal multi-phase field model.
We subsequently discretize implicitly in time and with linear finite elements.
The arising algebraic problem is formulated in two variables
where one is the multi-phase field,
and the other contains the inverse temperature field.
We solve this saddle point problem numerically by a non-smooth Schur–Newton approach
using truncated non-smooth Newton multigrid methods.
An application in grain growth as occurring in liquid phase crystallization of silicon is considered.
Experimental Investigation to Predict Tool Wear and Vibration Displacement in Turning – A Base for Tool Condition Monitoring
Authors: Babu M. Prakash , Prasad Balla Srinivasa 
Published: June 2016

AbstractIn the present work investigation primarily focuses on identifying the presence of cutting tool vibrations during face turning process. For this purpose an online non-contact vibration transducer i. e. laser Doppler Vibrometer is used as part of a novel approach. The revisions in the values of cutting forces, vibrations and acoustic optic emission signals with cutting tool wear are recorded and analyzed. This paper presents a mathematical model in an attempt to understand tool lifeunder vibratory cutting conditions. Tool wear and cutting force data are collected in the dry machiningof AISI 1040 steel at different vibrationinduced test conditions. Identifying the correlation among tool wear, cutting forces and displacement due to vibration is a critical task in the present study. These results are used to predict the evolution of displacement and tool wear in the experiment. Specifically, the research tasks include: to provide an appropriate experimental data to prove the mathematical model of tool wear based on the influence of cutting tool vibrations in turning.The modeling is focused on demonstrating the scientific relationship between the process variables such as vibration displacement, vibration amplitude, feedrate, depth of cut and spindle speed while getting into account machine dynamics effect and the effects such as surface roughness and tool wear generated in the operation. Present work also concentrates on the improvement in machinability during vibration assisted turning with different cutting tools. The effect of work piece displacement due to vibration on the tool wear is critically analyzed. Finally, tool wear is established on the basis of the maximum displacement that can be tolerated in a process for an effective tool condition monitoring system.
Comparison of adverse perinatal outcomes after single-needle and double-needle CVS techniques
Authors: Gezer Cenk , Ekin Atalay , Goynumer Gokhan , Pakay Kaan , Acar Hicran , Solmaz Ulas , Taner Cuneyt Eftal , Ozeren Mehmet 
Published: June 2016

AbstractObjective:To determine the impact of the chorion villus sampling (CVS) technique on adverse perinatal outcomes.Methods:In this case-control study, 412 women who underwent CVS at 11–14 weeks of gestation and 231 women who did not undergo any invasive procedure were retrospectively evaluated. The women in the CVS group were further divided into two groups according to the use of single-needle technique (n=148) vs. double-needle technique (n=264). The adverse outcomes were compared between controls and the two CVS groups, and regression analysis was used to determine the significance of independent contribution.Results:The rate of preeclampsia for the control group was 2.2%, for the double-needle group was 3% and for the single-needle group was 8.1%. CVS with single-needle technique was found to be an independent and statistically significant risk factor for preeclampsia [odds ratio (OR)=2.1, 95% confidence interval (CI); 1.4–2.7, P=0.008].Conclusion:The risk of preeclampsia after CVS appears to be increased with single-needle technique compared with double-needle technique.
A High-Efficient Low-Voltage Rectifier for CMOS Technology
Authors: Jendernalik Waldemar , Jakusz Jacek , Blakiewicz Grzegorz , Kłosowski Miron 
Published: June 2016

AbstractA new configuration of rectifier suiting CMOS technology is presented. The rectifier consists of only two n-channel MOS transistors, two capacitors and two resistors; for this reason it is very favourable in manufacturing in CMOS technology. With these features the rectifier is easy to design and cheap in production. Despite its simplicity, the rectifier has relatively good characteristics, the voltage and power efficiency, and bandwidth greater than 89%, 87%, and 1 GHz, respectively. The performed simulations and measurements of a prototype circuit fully confirmed its correct operation and advantages.
On Employing a Savitzky-Golay Filtering Stage to Improve Performance of Spectrum Sensing in CR Applications Concerning VDSA Approach
Authors: Angrisani Leopoldo , Capriglione Domenico , Cerro Gianni , Ferrigno Luigi , Miele Gianfranco 
Published: June 2016

Abstract
In this paper, a filtering stage based on employing a Savitzky-Golay (SG) filter is proposed to be used in the spectrum sensing phase of a Cognitive Radio (CR) communication paradigm for Vehicular Dynamic Spectrum Access (VDSA). It is used to smooth the acquired spectra, which constitute the input for a spectrum sensing algorithm. The sensing phase is necessary, since VDSA is based on an opportunistic approach to the spectral resource, and the opportunities are represented by the user-free spectrum zones, to be detected through the sensing phase. Each filter typology presents peculiarities in terms of its computational cost, de-noising ability and signal shape reconstruction. The SG filtering properties are compared with those of the linear Moving Average (MA) filter, widely used in the CR framework. Important improvements are proposed.
Current Injection Attack against the KLJN Secure Key Exchange
Authors: Chen Hsien-Pu , Mohammad Muneer , Kish Laszlo B. 
Published: June 2016

AbstractThe Kirchhoff-law-Johnson-noise (KLJN) scheme is a statistical/physical secure key exchange system based on the laws of classical statistical physics to provide unconditional security. We used the LTSPICE industrial cable and circuit simulator to emulate one of the major active (invasive) attacks, the current injection attack, against the ideal and a practical KLJN system, respectively. We show that two security enhancement techniques, namely, the instantaneous voltage/current comparison method, and a simple privacy amplification scheme, independently and effectively eliminate the information leak and successfully preserve the system’s unconditional security.
Prolonged response to pemetrexed-based chemotherapy in a patient with peritoneal mesothelioma: a case report and review of the literature
Authors: Študentová Hana , Vitásková Denisa , Čtvrtlík Filip , Melichar Bohuslav , Havlík Roman 
Published: June 2016

Abstract
Peritoneal mesothelioma is a rare tumor typically presenting with ascites and associated with occupational asbestos exposure with a latency period of 20–40 years. Intensive multi-modality approach combining cytoreductive surgery, intraperitoneal chemotherapy and possibly radiotherapy can be considered, but otherwise the prognosis is rather poor. Palliative chemotherapy may be an option in these rare cases. However, no approved systemic treatment exists for peritoneal mesothelioma. We present here a patient with peritoneal mesothelioma who was treated with the combination of pemetrexed with cisplatin shortly after the failure of hyperthermic intraperitoneal chemotherapy. The patient experienced durable partial response to the treatment, resolution of ascites, and returned to his normal daily life activities. With the exception of palliative chemotherapy in case of patients in good condition, therapeutic options in patients with peritoneal mesothelioma are currently very limited. The combination of pemetrexed and cisplatin can lead to long-term control in selected patients.
Incretin-based therapy for type 2 diabetes mellitus is promising for treating neurodegenerative diseases
Authors: Li Yanwei , Li Lin , Hölscher Christian 
Published: June 2016

Abstract
Incretin hormones include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Due to their promising action on insulinotropic secretion and improving insulin resistance (IR), incretin-based therapies have become a new class of antidiabetic agents for the treatment of type 2 diabetes mellitus (T2DM). Recently, the links between neurodegenerative diseases and T2DM have been identified in a number of studies, which suggested that shared mechanisms, such as insulin dysregulation or IR, may underlie these conditions. Therefore, the effects of incretins in neurodegenerative diseases have been extensively investigated. Protease-resistant long-lasting GLP-1 mimetics such as lixisenatide, liraglutide, and exenatide not only have demonstrated promising effects for treating neurodegenerative diseases in preclinical studies but also have shown first positive results in Alzheimer’s disease (AD) and Parkinson’s disease (PD) patients in clinical trials. Furthermore, the effects of other related incretin-based therapies such as GIP agonists, dipeptidyl peptidase-IV (DPP-IV) inhibitors, oxyntomodulin (OXM), dual GLP-1/GIP, and triple GLP-1/GIP/glucagon receptor agonists on neurodegenerative diseases have been tested in preclinical studies. Incretin-based therapies are a promising approach for treating neurodegenerative diseases.
Early prognostic factors at the time of diagnosis of bone metastasis in patients with bone metastases of differentiated thyroid carcinoma
Authors: Choi Yun Mi , Kim Won Gu , Kwon Hyemi , Jeon Min Ji , Lee Jong Jin , Ryu Jin-Sook , Hong Eun-Gyoung , Kim Tae Yong , Shong Young Kee , Kim Won Bae 
Published: June 2016

Objective
Bone is the second most common site of distant metastases from differentiated thyroid cancer (DTC). Patients with bone metastases were associated with poor clinical outcomes; however, their clinical courses are heterogeneous. The aim of this study is to evaluate early prognostic factors of patients with bone metastases from DTC at the time of diagnosis of bone metastasis.

Methods
This retrospective study included 93 patients with bone metastases from DTC. We defined ‘Pre-RAIT group’ as patients whose bone metastases were detected before initial RAIT. The ‘post-RAIT group’ was defined as patients whose bone metastases were detected after initial RAIT or during the follow-up period.

Results
Median age was 55.4years, and 55 patients (59%) had papillary thyroid cancer. Patients in the pre-RAIT group (n=32) demonstrated significantly poorer overall survival (OS) (HR=1.86, P=0.04) than those in the post-RAIT group. There was no significant difference in the OS according to the initial RAI avidity among all patients (P=0.18). RAI-avid bone metastases had better OS only in the pre-RAIT group (HR=0.23, P=0.01) but not in the post-RAIT group. In the post-RAIT group, older age (>45years), elevated serum thyroglobulin (Tg) level (>250ng/mL), and the presence of skeletal-related events (SREs) were significantly associated with poor OS. RAI avidity was not a significant prognostic factor in the post-RAIT group (P=0.33).

Conclusions
Patients whose bone metastases were diagnosed before initial RAIT demonstrate a poorer prognosis. RAI avidity is an early prognostic indicator in the pre-RAIT group. Old age, higher serum Tg levels, and SRE are associated with poor survival outcomes in the post-RAIT group.
Brasil: deuda pública ¿quién debe a quién?
Authors: Strautmann Gabriel 
Published: June 2016

<p align="justify">El documento presenta un análisis sobre la situación de la deuda pública brasilera y argumenta que a pesar de que el gobierno ha anunciado recientemente la condición de Brasil como Acreedor Externo Neto (situación en la que los activos financieros del país son mayores que sus pasivos), esto se debe fundamentalmente a una mala contabilización de los pasivos del país y a la subvaloración de los registros de la deuda pública y privada con el exterior. El autor señala que a pesar de los anuncios positivos del gobierno, el servicio de la deuda externa sigue siendo una carga onerosa para el presupuesto público brasilero, restando valiosos recursos para resolver los grandes problemas sociales y de pobreza que enfrenta el país.</p>