bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-canonical activity of the podosomal formin FMNL1γ supports immune cell migration
Authors: Miller Matthew R. , Miller Eric W. , Blystone Scott D. 
Published: March 2017

ABSTRACT
Having previously located the formin FMNL1 in macrophage podosomes, we developed an in vivo model to assess the role of FMNL1 in the migration activities of primary macrophages. Deletion of FMNL1 in mice was genetically lethal; however, targeted deletion in macrophages was achieved by employing macrophage-specific Cre. Unchallenged FMNL1-deficient mice exhibited an unexpected reduction in tissue-resident macrophages despite normal blood monocyte numbers. Upon immune stimulus, the absence of FMNL1 resulted in reduced macrophage recruitment in vivo, decreased migration in two-dimensional in vitro culture and a decrease in the number of macrophages exhibiting podosomes. Of the three described isoforms of FMNL1 – α, β and γ – only FMNL1γ rescued macrophage migration when expressed exogenously in depleted macrophages. Surprisingly, mutation of residues in the FH2 domain of FMNL1γ that disrupt barbed-end actin binding did not limit rescue of macrophage migration and podosome numbers. These observations suggest that FMNL1 contributes to macrophage migration activity by stabilizing the lifespan of podosomes without interaction of fast-growing actin termini.
Resiliência, população e território: contributo conceptual para a terminologia dos riscos
Authors: Castro Fátima Velez de , Lourenço Luciano 
Published: March 2017

O trabalho proposto pretende discutir o conceito de “resiliência”, encarando-o como um conjunto de capacidades e características inerentes ao meio físico e aos seres humanos, as quais se poderão modificar, com vista à redução da vulnerabilidade em contexto de recuperação, registada na sequência de perturbações dos sistemas naturais e antrópicos. Com base no efeito de antecipação-reação-recuperação, será abordada a génese do conceito, a suaapropriação terminológica por diversas ciências, assim como a derivação epistemológica, que resultou numa tipologia de resiliência(s) associadas às populações e aos territórios. https://doi.org/10.14195/1647-7723_24_1
The Northwestern Command’s Response to Insurgent Assaults on Dabat, Ethiopia
Authors: Ayele Fantahun 
Published: March 2017

Abstract
Between 1974 and 1991, the Ethiopian army was one of the largest and most heavily armed ground forces in Africa. In March 1978, it scored a decisive victory over Somalia. However, it failed to beat the northern insurgents despite its superiority in numbers and arms. On their part, the northern insurgents carefully studied the army’s weakest points and mounted surprise attacks on poorly defended positions. One such target that suffered from repeated insurgent onslaughts was Dabat, capital of the Wogara awrajja (subprovince) in northern Gondar. The army unit assigned to carry out counterinsurgency operations in that sector was the Northwestern Command. But mainly because of the serious problems within the command structure, the army miserably failed not only to hunt down insurgents but also to defend garrison towns like Dabat. The incidents that occurred at Dabat show us the internal crisis in the Northwestern Command. Using the untapped archives of the Ministry of National Defense and eyewitness accounts, this study seeks to uncover the army’s structural problems, such as intelligence failure, con flict among commanders and officials, infiltration, insubordination, indifference, and indiscipline.
Ireneo Peral: Forty Years as Mentor
Authors: Abdellaoui Boumediene , Aguilar Juan Antonio , Barrios Begoña , Colorado Eduardo , Charro Fernando , García Azorero Jesús , Medina Maria , Merchán Susana , Montoro Luigi , Primo Ana 
Published: March 2017

Abstract
In this article we present a survey of the Ph.D. theses that have been completed under the advice of Ireneo Peral.Following a chronological order, we summarize the main results contained in the works of the former students of Ireneo Peral.
Modeling of the Continuous Absorption of Electromagnetic Radiation in Dense Hydrogen Plasma
Authors: Mihajlov A. A. , Sakan N. M. , Srećković V. A. , Vitel Y. 
Published: March 2017

Abstract
We investigate a new modeling way for describing the continuous absorption of electromagnetic radiation in a dense partially ionized hydrogen plasma with electron densities 5·1018-1.5·1019 cm-3 and temperatures 16 000–25 000 K, in the wavelength range 300–500 nm. The results can be applied to the plasma of partially ionized layers of stellar atmospheres.
Hydrodynamic Studies of the Evolution of Recurrent, Symbiotic and Dwarf Novae: the White Dwarf Components are Growing in Mass
Authors: Starrfield S. , Timmes F. X. , Iliadis C. , Hix W. R. , Arnett W. D. , Meakin C. , Sparks W. M. 
Published: March 2017

Abstract
Symbiotic binaries are systems containing white dwarfs (WDs) and red giants. Symbiotic novae are those systems in which thermonuclear eruptions occur on the WD components. These are to be distinguished from events driven by accretion disk instabilities analogous to dwarf novae eruptions in cataclysmic variable outbursts. Another class of symbiotic systems are those in which the WD is extremely luminous and it seems likely that quiescent nuclear burning is ongoing on the accreting WD. A fundamental question is the secular evolution of the WD. Do the repeated outbursts or quiescent burning in these accreting systems cause the WD to gain or lose mass? If it is gaining mass, can it eventually reach the Chandrasekhar Limit and become a supernova (a SN Ia if it can hide the hydrogen and helium in the system)? In order to better understand these systems, we have begun a new study of the evolution of Thermonuclear Runaways (TNRs) in the accreted envelopes of WDs using a variety of initial WD masses, luminosities and mass accretion rates. We use our 1-D hydro code, NOVA, which includes the new convective algorithm of Arnett, Meakin and Young, the Hix and Thielemann nuclear reaction solver, the Iliadis reaction rate library, the Timmes equation of state, and the OPAL opacities. We assume a solar composition (Lodders abundance distribution) and do not allow any mixing of accreted material with core material. This assumption strongly influences our results. We report here (1) that the WD grows in mass for all simulations so that ‘steady burning’ does not occur, and (2) that only a small fraction of the accreted matter is ejected in some (but not all) simulations. We also find that the accreting systems, before thermonuclear runaway, are too cool to be seen in X-ray searches for SN Ia progenitors.
A New Approach to the Long-Term Activity Behavior of DM UMa
Authors: Taş G. , Evren S. 
Published: March 2017

Abstract
A long-term activity character of DM UMa (K0-1 IV-III), which is one of the most active members of the RS CVn type variables, is examined using the multicolor photometric observations which spread to the time interval between 1980 and 2009. In this work, we present a new approximation for the long-term light and color variation of DM UMa using data obtained by combining our own observations obtained in the Johnson broad-band U,B,V,R filters between the years 1997 and 2008 and data published in literature. Available light and color data were examined for the long-term and seasonal variations using PERIOD04 program. The period analysis of the V-band data reveals the period estimations of 51.2±2.8 years and 15.1±0.7 years superposed on it. The U-B, B-V and V-R colors do not show correlation with the longer period, but they show variations with a period similar to the shorter one, except for B-V color. The amplitude variation also does not exhibit any correlation with the V light and color curves. It is found that the movement of the spot minima phases in years also indicates the migration period of nearly 15 years, similar to the period derived from the analysis of the long-term photometric observations in V-band.
Der neugefundene Text eines Briefes von Maximos Katelianos: noch eine Fälschung von Karl Benedikt Hase
Authors: Medvedev Igor P. 
Published: March 2017

AbstractIn July 1816, answering a request of the Russian count Nikolay Petrovič Rumjanzev, Karl Benedikt Hase wrote him that the Byzantine toponym Sarat should be identified with today’s town of Sudak. Hase’s hypothesis relied on a letter by a certain Maximos Katelianos, dating to the late 13th or early 14th century, preserved - as Hase assured - in the Bibliothèque royale of Paris. In 1971, Ihor Ševčenko argued that Katelianos and his letter had been merely invented by Hase for the satisfaction of Rumjanzev’s curiosity. Actually, Hase attached an autograph copy of Katelianos’ letter to the letter he wrote to Rumjanzev, which the author of this article has recently found among the papers of Alexej Nikolaevič Olenin. In 2006 Ševčenko identified the Oratio gratiosa of John Eugenikos from Par. gr. 2075 as Hase’s direct source for composing the letter of ‘Maximos Katelianos’. The present article includes the letter in Greek with Hase’s Latin translation, accompanied by a new one into German.
The second coordinate sequence of the MP-LRS over nontrivial Galois ring of an odd characteristic
Authors: Tsypyschev Vadim N. 
Published: March 2017

Abstract
A Galois ring is said to be nontrivial if it is neither a field, nor a residue ring. Divisors and multiples of the minimal polynomial of the second p-adic coordinate sequence of a linear recurrent sequence of maximum period (MP LRS) over a nontrivial Galois ring of an odd characteristic are described, as well as their relation to the initial vector of the LRS. As a corollary, nontrivial upper and lower bounds for the rank of the second coordinate sequence of a MP LRS over a nontrivial Galois ring of an odd characteristic are obtained.
Multimodal existential constructions in German: Manual actions of giving as experiential substrate for grammatical and gestural patterns
Authors: Mittelberg Irene 
Published: March 2017

AbstractTaking an Emergent Grammar (Hopper 1998) approach to multimodal usage events in face-to-face interaction, this paper suggests that basic scenes of experience tend to motivate entrenched patterns in both language and gesture (Fillmore 1977; Goldberg 1998; Langacker 1987). Manual actions and interactions with the material and social world, such as giving or holding, have been shown to serve as substrate for prototypical ditransitive and transitive constructions in language (Goldberg 1995). It is proposed here that they may also underpin multimodal instantiations of existential construsctions in German discourse, namely, instances of the es gibt ‘it gives’ (there is/are) construction (Newman 1998) that co-occur with schematic gestural enactments of giving or holding something. Analyses show that gestural existential markers tend to combine referential and pragmatic functions. They exhibit a muted degree of indexicality, pointing to the existence of absent or abstract discourse contents that are central to the speaker’s subjective expressivity. Furthermore, gestural existential markers show characteristics of grammaticalization processes in spoken and signed languages (Bybee 2013; Givón 1985; Haiman 1994; Hopper and Traugott 2003). A multimodal construction grammar needs to account for how linguistic constructions combine with gestural patterns into commonly used cross-modal clusters in different languages and contexts of use.
Is there a multimodal construction based on non-deicticsoin German?
Authors: Ningelgen Jana , Auer Peter 
Published: March 2017

AbstractThe existence of multimodal constructions is highly disputed. One of the most straightforward examples of such constructions includes deictics, among them the German manner adverbial so (‘like this’) (cf. Stukenbrock 2014a, Take the words out of my mouth: Verbal instructions as embodied practices.Journal of Pragmatics65. 80–102, 2015,Deixis in der Face-to-Face-Interaktion. Berlin, München & Boston: De Gruyter), whose deictic use requires a constellation of grammatical, prosodic and gestural as well as gaze-related features. While this multimodal construction is uncontroversial, this paper tests (and refutes) the broader claim that Germansoisregularlyaccompanied by gestures (Streeck 2002: 582, Grammars, words, and embodied meanings. On the evolution and uses ofsoandlike.Journal of Communication52(3). 581–596). We show that non-stressed, non-deicticsocan but need not be coupled with an iconic gesture and hence doesn’t qualify as a multimodal construction.
The shrug as marker of obviousness
Authors: Jehoul Annelies , Brône Geert , Feyaerts Kurt 
Published: March 2017

Abstract
This contribution focuses on the shrug as it is used in stance taking contexts in face-to-face conversations. The shrug qualifies as a ‘compound enactment’, in which prototypically different gestures are combined: “the eye-brows (which are being raised), the hands (which are turned so that the palms face up), the forearms (which may be lifted), and the shoulders (which are also raised). In addition, the head may be tilted” (Streeck 2009: 189. Gesturecraft. The manu-facture of meaning. Amsterdam: Benjamins). More recent studies show that instead of a head tilt, a headshake can also be a part of the shrug (Schoonjans 2014. Modalpartikeln als multimodale Konstruktionen: Eine korpusbasierte Kookkurrenzanalyse von Modalpartikeln und Gestik im Deutschen. Leuven: KU Leuven dissertation). We report on an empirical study, in which the shrug or some of its gestural components are used to express obviousness on the part of the speaker. Although our data reveal multimodal patterns in the expression of obviousness, this study singles out the gestural dimension. The paper is structured as follows. Section 2 explains the methodological aspects of our study, after which Section 3 presents the formal and quantitative results, illustrated with four examples. The paper ends in Section 4 with a brief discussion of our major findings.
Plattformtechnologie für die mobile,
markerfreie Proteindetektion
Authors: Jahns Sabrina , Neustock Lars Thorben , Paulsen Moritz , Moussavi Elmira , Gerken Martina 
Published: March 2017

Zusammenfassung
Wir präsentieren eine Plattformtechnologie zur gleichzeitigen,
mobilen, markerfreien Detektion von mehreren Proteinen. Ein
photonischer Kristall, der mit Liganden lokal funktionalisiert ist,
dient hier als Sensor. Über ein kompaktes, Kamera-basiertes
Messsystem wird die Proteinanbindung an die Sensoroberfläche in
ein Intensitätssignal umgewandelt, über dessen Amplitude die
Proteinkonzentration bestimmt werden kann. Um das Detektionslimit
dieser Technologie weiter zu verbessern, werden hier photonische
Kristalle mit einer multiperiodischen und aperiodischen Gitterstruktur
simulativ und experimentell untersucht. Dafür werden die
Gesamtempfindlichkeit und die Resonanzgüte jeder Struktur bestimmt
und mit der bisher verwendeten monoperiodischen Struktur
verglichen. Es konnte festgestellt werde, dass sich die
Resonanzgüte von mono- über multi- bis aperiodisch deutlich
verbessert. Eine Steigerung der Gesamtempfindlichkeit konnte nicht
festgestellt werden. Jedoch konnte anhand von Analysen der
elektrischen Feldverteilung innerhalb der verschiedenen Strukturen
beobachtet werden, dass die Modenausbreitungen in den aperiodischen
Strukturen stark lokalisiert wird und die elektrische
Feldintensität in diesen „Hot-Spots“ deutlich über der
mittleren Feldintensität, die eine flächige Funktionalisierung
repräsentiert, liegt. Diese lokale Resonanzausbildung konnte zudem
bereits in ersten experimentellen Untersuchungen bestätigt
werden.
Driving Human Motor Cortical Oscillations Leads to Behaviorally Relevant Changes in Local GABAAInhibition: A tACS-TMS Study
Authors: Nowak Magdalena , Hinson Emily , van Ede Freek , Pogosyan Alek , Guerra Andrea , Quinn Andrew , Brown Peter , Stagg Charlotte J. 
Published: March 2017

Beta and gamma oscillations are the dominant oscillatory activity in the human motor cortex (M1). However, their physiological basis and precise functional significance remain poorly understood. Here, we used transcranial magnetic stimulation (TMS) to examine the physiological basis and behavioral relevance of driving beta and gamma oscillatory activity in the human M1 using transcranial alternating current stimulation (tACS). tACS was applied using a sham-controlled crossover design at individualized intensity for 20 min and TMS was performed at rest (before, during, and after tACS) and during movement preparation (before and after tACS). We demonstrated that driving gamma frequency oscillations using tACS led to a significant, duration-dependent decrease in local resting-state GABAAinhibition, as quantified by short interval intracortical inhibition. The magnitude of this effect was positively correlated with the magnitude of GABAAdecrease during movement preparation, when gamma activity in motor circuitry is known to increase. In addition, gamma tACS-induced change in GABAAinhibition was closely related to performance in a motor learning task such that subjects who demonstrated a greater increase in GABAAinhibition also showed faster short-term learning. The findings presented here contribute to our understanding of the neurophysiological basis of motor rhythms and suggest that tACS may have similar physiological effects to endogenously driven local oscillatory activity. Moreover, the ability to modulate local interneuronal circuits by tACS in a behaviorally relevant manner provides a basis for tACS as a putative therapeutic intervention.SIGNIFICANCE STATEMENTGamma oscillations have a vital role in motor control. Using a combined tACS-TMS approach, we demonstrate that driving gamma frequency oscillations modulates GABAAinhibition in the human motor cortex. Moreover, there is a clear relationship between the change in magnitude of GABAAinhibition induced by tACS and the magnitude of GABAAinhibition observed during task-related synchronization of oscillations in inhibitory interneuronal circuits, supporting the hypothesis that tACS engages endogenous oscillatory circuits. We also show that an individual's physiological response to tACS is closely related to their ability to learn a motor task. These findings contribute to our understanding of the neurophysiological basis of motor rhythms and their behavioral relevance and offer the possibility of developing tACS as a therapeutic tool.
Etnologia aplicada e indigenismo no México: a trajetória de Salomon Nahmad vista do Brasil
Authors: Aires Max Maranhão Piorsky 
Published: March 2017

Este artigo analisa a antropologia aplicada no México a partir da trajetória profissional do antropólogo Salomón Nahmad, com a finalidade de explorar a confluência entre texto etnográfico, narrativa autobiográfica, contexto políticoideológico e a formulação de teorias e conceitos antropológicos como resposta a problemas práticos. O objetivo é compreender este estilo de antropologia, suas variações ao longo da carreira do antropólogo, e, em seguida, sob a perspectiva da antropologia praticada no Brasil, realizar alguns apontamentos sobre a relação entre antropologia e indigenismo.
Editorial
Authors: De Gloria Alessandro 
Published: March 2017

Before introducing the new IJSG issue, the first one of the fourth year, I am proud to announce also from these columns the sixth edition of the Gala Conference, that will be held in Lisbon, 5th to 7th December 2017 https://conf.seriousgamessociety.org/. The general chair is João Dias, of INESC-ID and Instituto Superior Técnico, Universidade de Lisboa. It will be another great occasion to meet each other – old and new members of this ever-growing Serious Games Society community - learn personally from our research, and checking the market/industry trends. As in the previous edition, the conference will also host workshops, exhibitions and competitions.The present IJSG issue features five valuable papers, that bring new, significant insights in the field, providing different perspectivesThe present IJSG issue features five valuable papers, that bring new, significant insights in the field, providing different perspectives.
Knowledge, attitudes and practices about goiter among population in Shendi provence. River Nile state of Sudan
Authors: Elmanssury Ahmed Elnadif , Dafaalla Safa Abdalla 
Published: March 2017

Background: Globally, about 2 thousand million people are affected by iodine deficiency. The aim of this study is to Knowledge, attitudes and practices regarding goiter among population in Shendi Provence. River Nile State of Suda. Methods: This study was conducted as a community based descriptive Cross – sectional study. In this study 636 households were included .Questionnaire were used as tools for data collection. The households were selected through a multistage cluster-sampling technique, three cluster stage was used (The locality was divided into four administrative units, All administrative units were divided into cluster villages or block and The required number of households in each village and block was selected by following the systemic random sampling technique) 636 respondents were selected. Results: The study was found that (58.5%) of respondents were recognize goiter disease as an enlargement of thyroid gland. More than sixty (63.4%) were aware of the causes of goiter and its symptoms, (56%) were aware of iodine. More than half of respondents (55.8%) were aware of sources of iodine, (47%) of respondents were aware of foods contain iodine and its types. In addition, study revealed that (41%) of participant were aware of iodized salt. Moreover (48%) of respondents consider that iodized salt is necessary. The results revealed that only 82 (12.9%) were applied Preventive measures. Conclusions: The overall knowledge of respondent regarding goiter were found to be good, they had negative attitude towards goiter and they had proper practice in consumption of food contain.
Knowledge, attitude and practice regarding sickle cell disease in adult sufferers and carriers in a rural area
Authors: Patil Sonali S. , Thikare Anand A. , Wadhva Sarita K. , Narlawar Uday W. , Shukla Shruti 
Published: March 2017

Background: According to State Health Society, there are about 30 lakhs sickle cell carrier and 1.5 lakhs sufferers in Maharashtra, prevalence being more in tribal population. As Sickle cell disease is associated with increased morbidity and mortality, it is important for patients to have awareness regarding its cause, treatment and genetic implication. To assess Knowledge, Attitude and Practices regarding sickle cell disease in adult sufferers and carriers.Materials and Methods: The present study is an cross sectional study, carried out in 232 adult sickle cell disease sufferers and carriers in rural area of Chandrapur district from July 2014 to December 2015.Results: Out of 232 study subjects, 17.24% were sufferers and 82.76% were carriers. Only 62.50% knew the correct cause and only 42.67% had correct knowledge of types of disease. 76.30% had correct knowledge about symptoms of disease. 40.09% patients were availing treatment of some kind. It was found that only 6.77% had done premarital screening of their spouses and 100% had screened their children for sickle cell disease.Conclusion: Knowledge regarding sickle cell disease, its cause, types, treatment and prevention is satisfactory in sufferers but not in carriers. Overall attitude towards treatment and prevention is more or less positive. Treatment seeking behavior is good in sufferers but not in carriers.