bluuebunny/crossref_metadata_2025_split huggingface dataset:
Increased activity of the orexin system in the paraventricular nucleus contributes to salt-sensitive hypertension
Authors: Huber Michael J. , Fan Yuanyuan , Jiang Enshe , Zhu Fengli , Larson Robert A. , Yan Jianqun , Li Ningjun , Chen Qing-Hui , Shan Zhiying 
Published: June 2017

The orexin system is involved in arginine vasopressin (AVP) regulation, and its overactivation has been implicated in hypertension. However, its role in salt-sensitive hypertension (SSHTN) is unknown. Here, we tested the hypothesis that hyperactivity of the orexin system in the paraventricular nucleus (PVN) contributes to SSHTN via enhancing AVP signaling. Eight-week-old male Dahl salt-sensitive (Dahl S) and age- and sex-matched Sprague-Dawley (SD) rats were placed on a high-salt (HS; 8% NaCl) or normal-salt (NS; 0.4% NaCl) diet for 4 wk. HS intake did not alter mean arterial pressure (MAP), PVN mRNA levels of orexin receptor 1 (OX1R), or OX2R but slightly increased PVN AVP mRNA expression in SD rats. HS diet induced significant increases in MAP and PVN mRNA levels of OX1R, OX2R, and AVP in Dahl S rats. Intracerebroventricular infusion of orexin A (0.2 nmol) dramatically increased AVP mRNA levels and immunoreactivity in the PVN of SD rats. Incubation of cultured hypothalamus neurons from newborn SD rats with orexin A increased AVP mRNA expression, which was attenuated by OX1R blockade. In addition, increased cerebrospinal fluid Na+ concentration through intracerebroventricular infusion of NaCl solution (4 µmol) increased PVN OX1R and AVP mRNA levels and immunoreactivity in SD rats. Furthermore, bilateral PVN microinjection of the OX1R antagonist SB-408124 resulted in a greater reduction in MAP in HS intake (−16 ± 5 mmHg) compared with NS-fed (−4 ± 4 mmHg) anesthetized Dahl S rats. These results suggest that elevated PVN OX1R activation may contribute to SSHTN by enhancing AVP signaling. NEW & NOTEWORTHY To our best knowledge, this study is the first to investigate the involvement of the orexin system in salt-sensitive hypertension. Our results suggest that the orexin system may contribute to the Dahl model of salt-sensitive hypertension by enhancing vasopressin signaling in the hypothalamic paraventricular nucleus.
Immunotherapy of Prostate Cancer: Facts and Hopes
Authors: Bilusic Marijo , Madan Ravi A. , Gulley James L. 
Published: June 2017

Abstract
In the last few years, immunotherapy has become an important cancer treatment modality, and although the principles of immunotherapy have evolved over many decades, the FDA approvals of sipuleucel-T and ipilimumab began a new wave in immuno-oncology. Despite the current enthusiasm, it is unlikely that any of the immunotherapeutics alone can dramatically change prostate cancer outcomes, but combination strategies are more promising and provide a reason for optimism. Several completed and ongoing studies have shown that the combination of cancer vaccines or checkpoint inhibitors with different immunotherapeutic agents, hormonal therapy (enzalutamide), radiotherapy (radium 223), DNA-damaging agents (olaparib), or chemotherapy (docetaxel) can enhance immune responses and induce more dramatic, long-lasting clinical responses without significant toxicity. The goal of prostate cancer immunotherapy does not have to be complete eradication of advanced disease but rather the return to an immunologic equilibrium with an indolent disease state. In addition to determining the optimal combination of treatment regimens, efforts are also ongoing to discover biomarkers of immune response. With such concerted efforts, the future of immunotherapy in prostate cancer looks brighter than ever. Clin Cancer Res; 23(22); 6764–70. ©2017 AACR.
Resenha Geografias da Memória
Authors: Vilar Fernanda Salomão 
Published: June 2017

O livro Geometrias da Memória: configurações pós-coloniais é o primeiro volume da série “Memoirs – Filhos de Império”, do grupo de pesquisa de mesmo nome MEMOIRS – Filhos de Império e Pós-memórias Europeias (http://memoirs.ces.uc.pt) financiado pelo Conselho Europeu de Pesquisa (ERC). Organizado por António Sousa Ribeiro e Margarida Calafate Ribeiro, o livro interroga o lugar da memória e da pós-memória colonial na narrativa da história europeia.
The Economic Approach to Crime and Punishment
Authors: Pyle D.J. 
Published: June 2017

In the last twenty five years, economists have devoted considerable research effort to the study of crime and punishment. This article examines the contribution made by economists in two particular areas. First, the economic analysis of participation in criminal activity. Second, the design of “efficient” punishments for convicted criminals. The economic approach to crime and punishment assumes that criminals are rational individuals, who respond to incentives. Empirical analysis, undertaken by economists, tends to confirm this view. Several consequences follow from this, especially in relation to the structure of punishments for (related) crimes. In particular punishments need to be designed so that criminals choose less, rather than more, harmful acts.
The Many Roads toward Achieving Health Equity
Authors: Cohen Alan B. , Grogan Colleen M. , Horwitt Jedediah N. 
Published: June 2017

Abstract
This special issue of the Journal is devoted to understanding the many roads that lead toward achieving health equity. The eleven articles in the issue portray an America that is struggling with the clash between its historical ideal of pursuing equality for all and its ambivalence toward achieving equity in all social domains, especially health. Organized in five sections, the issue contains articles that examine and analyze: the role of civil rights law and the courts in shaping health equity; the political discourse that has framed our understanding of health equity; health policies that affect health equity, such as the Medicaid program, as well as related strategies that might help to improve equity, such as the use of mobile technologies to empower individuals; immigration policies and practices that impact health equity in marginalized populations; and commentaries in the final section that explore how the Affordable Care Act has addressed health equity, how repeal of the law would jeopardize equity gains, and how the political discourse and culture of the Trump administration could adversely affect health equity.
Health Equity in a Trump Administration
Authors: Stone Deborah 
Published: June 2017

Abstract
Donald Trump's rhetoric and leadership are destroying the “culture of community” necessary for progress on health equity. His one-line promises to provide “quality health care at a fraction of the cost” smack of neoliberal nostrums that shifted ever more costs onto patients, thereby preventing many people from getting care. The dangers of Trump go far beyond health policy, however; Trump's presidency threatens the political and cultural institutions that make any good policy possible.
Exact Simulation of the SABR Model
Authors: Cai Ning , Song Yingda , Chen Nan 
Published: June 2017

The stochastic alpha-beta-rho (SABR) model becomes popular in the financial industry because it is capable of providing good fits to various types of implied volatility curves observed in the marketplace. However, no analytical solution to the SABR model exists that can be simulated directly. This paper explores the possibility of exact simulation for the SABR model. Our contribution is threefold. (i) We propose an exact simulation method for the forward price and its volatility in two special but practically interesting cases, i.e., when the elasticity β = 1, or when β < 1 and the price and volatility processes are instantaneously uncorrelated. Primary difficulties involved are how to simulate two random variables whose distributions can be expressed in terms of the Hartman-Watson and the noncentral chi-squared distribution functions, respectively. Two novel simulation schemes are proposed to achieve numerical accuracy, efficiency, and stability. One stems from numerical Laplace inversion and Asian option literature, and the other is based on recent developments in evaluating the noncentral chi-squared distribution functions in a robust way. Numerical examples demonstrate that our method is fast and accurate under various market environments. (ii) When β < 1 but the price and volatility processes are correlated, our simulation method becomes a semi-exact one. Numerical results suggest that it is still quite accurate when the time horizon is not long, e.g., no greater than one year. For long time horizons, a piecewise semi-exact simulation scheme is developed that reduces the biases substantially. (iii) For European option pricing under the SABR model, we propose a conditional simulation method, which reduces the variance of the plain simulation significantly, e.g., by more than 99%. The e-companion is available at https://doi.org/10.1287/opre.2017.1617 .
Betwixt fiction and documentary
Authors: Shōhei Imamura 
Published: June 2017

Abstract
‘Betwixt fiction and documentary’ is Imamura Shōhei’s most cohesive articulation of his quest for a cinema-truth, where fiction and documentary crossover. This short essay situates Imamura’s development as a filmmaker via reference to historical events that variously impacted on the style and form of his work. The original Japanese essay can be found in: S. Imamura (ed.) (2001), Toru: Kannu kara Yamiichi e, Tokyo: Kōsakusha, pp. 234–38.
Imamura Shōhei: Betwixt fiction and documentary − an introduction
Authors: Mihalopoulos Bill 
Published: June 2017

Abstract
‘Betwixt fiction and documentary’ reveals Imamura’s development as a filmmaker through reference to historical events that shaped the style and form of his work. Imamura traces his quest for an authentic cinematic to his involvement in the black market in the years immediately after Japan’s surrender and occupation. ‘Betwixt fiction and documentary’ also gives the background to why Imamura turned his back on commercial filmmaking for most of the 1970s.
ANÁLISE DE BULAS DOS MEDICAMENTOS À BASE DE GINKGO BILOBA L. COMERCIALIZADAS EM PATOS DE MINAS, MINAS GERAIS, BRASIL
Authors: Andrade Érica Belchior de Lima , Ferreira Lilian Abreu 
Published: June 2017

Os medicamentos industrializados elaborados a partir do extrato padronizado de Ginkgo biloba L. são encontrados em farmáciascomunitárias principalmente nas formas de cápsulas e comprimidos. Ao adquirirem o medicamento industrializado, os usuários têm a bula como principal fonte de informação impressa, e para que as informações contidas nesta cumpram sua finalidade, devem ser apresentadas de maneira objetiva, atualizada e completa. Assim, o objetivo do estudo foi analisar as bulas dos medicamentos à base de extrato seco de Ginkgo biloba L. frente às normas exigidas pela RDC nº 47/2009 da Anvisa. Foi realizado um estudo observacional com análise das bulas dos fitoterápicos contendo Ginkgo biloba L. como monofármaco, na forma farmacêutica de cápsulas ou comprimidos, comercializados nas farmácias comunitárias da cidade de Patos de Minas, em relação aos tópicos: Identificação do medicamento, Informações ao paciente, Dizeres legais e Frases obrigatórias. Do total de especialidades farmacêuticas, duas não possuíam bula. Em 45% das bulas, algumas das frases obrigatórias estavam ausentes. Uma bula trazia informação conflitante sobre o real aspecto físico do medicamento. Das informações aos pacientes, 48% das bulas apresentaram-se incompletas, algumas com indicações de uso não estabelecidas pela legislação. Todas as bulas apresentaram as informações referentes aos tópicos Dizeres Legais e Identificação do medicamento, completas. Mesmo diante de uma legislação específica, ainda existem fitoterápicos com suas respectivas bulas fora dos padrões estabelecidos. As bulas podem ter sua função precípua desviada quando deixam de ser um material educativo e informativo tornando-se fonte de confusão e incentivo ao uso incorreto.
AVALIAÇÃO IN VITRO DE ALTERAÇÕES EM LACTUCA SPP. DE SACCHAROMYCES CEREVISEAE NA PRESENÇA DE FÁRMACOS
Authors: Coronetti Mayse Rosa , Cortes Amerieli Leticia Marquezoti , Franzen Mitaly , Hosoi Bruna Maki Utsunomiya , Alves Gabriel Neves , Nicolini Jaqueline , NICOLINI KELLER PAULO 
Published: June 2017

A presença de contaminantes emergentes em águas de superfície foi detectada em estudos realizados por pesquisadores de vários países. Neste estudo foram monitorados parâmetros fisiológicos de substratos contaminados pelos antibacterianos, nitrofurantoína (NTF), cloridrato de tetraciclina (CTC), cefalexina (CEF), amoxicilina (AMX), azitromicina (AZI) e norfloxacina (NOR) e pelos analgésicos, diclofenaco de sódio (DFS), dipirona monoidratada (DMH) e diclofenaco de potássio (DFP), em culturas de Lactuca spp. (alface) e de Saccharomyces cereviseae in vitro.Todas as substâncias avaliadas causam alterações metabólicas e fisiológicas na cultura de Lactuca spp., alterando a taxa de germinação, o comprimento de folhas, o comprimento de raízes e as taxas de clorofila alfa e de clorofila beta. No entanto apenas NOR, DFS e DMH causam alterações na concentração inibitória para a produção de espuma de S.cereviseae em concentrações ≤ 5000 ppm.
INTERAÇÕES PLANTA MEDICINAL X MEDICAMENTO CONVENCIONAL NO TRATAMENTO DA HIPERTENSÃO ARTERIAL
Authors: Ataliba Fábia Jéssica Batista , Da Costa Danielly Albuquerque , Farias Andrezza Duarte , Souza Júlia Beatriz Pereira 
Published: June 2017

A hipertensão arterial sistêmica, dentre as doenças crônicas, apresenta-se como um dos problemas de saúde de maior magnitude na atualidade, sendo uma das principais causas de morbidade e mortalidade cardiovascular no Brasil. Seu tratamento consiste na utilização de medicamentos convencionais e plantas medicinais, sendo essa associação cada vez mais frequente, aumentando os riscos de ocorrência de interações. Este trabalho teve como objetivo descrever, mediante revisão de literatura, as principais interações entre plantas medicinais e medicamentos sintéticos utilizados na terapia da hipertensão arterial e discutir as implicações do uso concomitante desses produtos. Foi realizada uma revisão da literatura em trabalhos publicados no período de 2006 a 2016, abordando interações de medicamentos com plantas medicinais a partir de levantamento entofarmacológico, seguido e estudos de comprovação da atividade anti-hipertensiva. As plantas reconhecidas para o tratamento de hipertensão foram Allium sativum, Alpinia zerumbet, Citrus sp., Lippia alba, Passiflora sp., Cymbopogon citratus, Sechium edule. Foram avaliadas as possíveis interaçõesdessas plantas com os medicamentos convencionais para tratar hipertensão. Foi observado que as principais interações envolvidas no uso concomitante entre plantas medicinais e fármacos são do tipo farmacodinâmicas. Dessa forma se faz necessário ter cautela ao associar o uso de plantas aos medicamentos.
White Blood Cell Subtypes Are Associated with a Greater Long-Term Risk of Death after Acute Myocardial Infarction
Authors: Shiyovich Arthur , Gilutz Harel , Plakht Ygal 
Published: June 2017

We evaluated the association between white blood cell counts and long-term mortality rates in 2,129 patients (mean age, 65.3 ± 13.5 yr; 69% men) who had survived acute myocardial infarction. We obtained white blood cell counts and differential counts of white blood cell subtypes within the first 72 hours of hospital admission. The primary outcome was all-cause death at 1, 5, and 10 years after acute myocardial infarction.
In regard to death in the long term, we found significant negative linear associations (lymphocytes), positive linear associations (neutrophils and the neutrophil-to-lymphocyte ratio), and nonlinear U-shaped associations (basophils, eosinophils, monocytes, and total white blood cell count). After multivariate adjustment for the Soroka Acute Myocardial Infarction risk score, lymphocytes (strongest association), neutrophil-to-lymphocyte ratio, and eosinophils were independently associated with death for up to 10 years after hospital discharge. The independent associations weakened over time.
We conclude that lymphocyte count, neutrophil-to-lymphocyte ratio, and eosinophil count are independently and incrementally associated with death in the long term after acute myocardial infarction.
Degradation of anti-inflammatory drug diclofenac in sewage water
Authors: Gazdová Katarína , Kubiňáková Emília , Híveš Ján , Mackuľak Tomáš 
Published: June 2017

Abstract
In recent years, interest in the presence of chemical and biological pollutants (drugs, pesticides, heavy metals etc.) in sewage water has been permanently increasing and, at the same time, significant effort to eliminate them has been shown. The aim of this work was to investigate the influence of ferrates activity on the decomposition of the drug diclofenac (DCF), which is commonly present in sewage water. The main task is to follow the effect of potassium ferrate dosage on DCF degradation and to evaluate the most effective ferrates concentration in solution. Subsequently, real samples of waste water containing a significant amount of various micro‑pollutants were treated by the same amount of ferrates as laboratory samples. High-performance liquid chromatography (HPLC) was used for the sample analysis. Ferrates removal effectiveness was determined by comparing the chromatographic peak areas of residual DCF in the treated samples. Removal efficiency of diclofenac is proportional to the concentration of potassium ferrate in the treated solutions.
Delivery-flow routing and scheduling subject to constraints imposed by vehicle flows in fractal-like networks
Authors: Bocewicz Grzegorz , Banaszak Zbigniew , Nielsen Izabela 
Published: June 2017

Abstract
The problems of designing supply networks and traffic flow routing and scheduling are the subject of intensive research. The problems encompass the management of the supply of a variety of goods using multi-modal transportation. This research also takes into account the various constraints related to route topology, the parameters of the available fleet of vehicles, order values, delivery due dates, etc. Assuming that the structure of a supply network, constrained by a transport network topology that determines its behavior, we develop a declarative model which would enable the analysis of the relationships between the structure of a supply network and its potential behavior resulting in a set of desired delivery-flows. The problem in question can be reduced to determining sufficient conditions that ensure smooth flow in a transport network with a fractal structure. The proposed approach, which assumes a recursive, fractal network structure, enables the assessment of alternative delivery routes and associated schedules in polynomial time. An illustrative example showing the quantitative and qualitative relationships between the morphological characteristics of the investigated supply networks and the functional parameters of the assumed delivery-flows is provided.
Availability analysis of selected mining machinery
Authors: Brodny Jarosław , Alszer Sara , Krystek Jolanta , Tutak Magdalena 
Published: June 2017

Abstract
Underground extraction of coal is characterized by high variability of mining and geological conditions in which it is conducted. Despite ever more effective methods and tools, used to identify the factors influencing this process, mining machinery, used in mining underground, work in difficult and not always foreseeable conditions, which means that these machines should be very universal and reliable. Additionally, a big competition, occurring on the coal market, causes that it is necessary to take action in order to reduce the cost of its production, e.g. by increasing the efficiency of utilization machines. To meet this objective it should be pro-ceed with analysis presented in this paper. The analysis concerns to availability of utilization selected mining machinery, conducted using the model of OEE, which is a tool for quantitative estimate strategy TPM. In this article we considered the machines being part of the mechanized longwall complex and the basis of analysis was the data recording by the industrial automation system. Using this data set we evaluated the availability of studied machines and the structure of registered breaks in their work. The results should be an important source of information for maintenance staff and management of mining plants, needed to improve the economic efficiency of underground mining.
The effect of cigarette smoking on endothelial damage and atherosclerosis development – modeled and analyzed using Petri nets
Authors: Chmielewska Kaja , Formanowicz Dorota , Formanowicz Piotr 
Published: June 2017

Abstract
Atherosclerosis as one of the crucial causes of cardiovascular diseases (CVD) is the leading reason of death worldwide. One of the contributing factors to this phenomenon is endothelial dysfunction, which is associated with the impact of various agents and their interactions. Tobacco smoke is one of the well known factors here. For better understanding of its significance a model of its impact on atherosclerotic plaque formation has been proposed. The model contains selected aspects of the influence of tobacco smoke, dual function of nitric oxide (NO) (influence of various mechanisms on NO bioavailability), oxidative stress which promotes low density lipoproteins oxidation, macrophages significance and other mechanisms leading to an aggravation of the endothelial disturbances. The model has been built using Petri nets theory and the analysis has been based on t-invariants. This approach allowed to confirm the important role of inflammation and oxidative stress in atherosclerosis development and moreover it has shown the considerable influence of the cigarette smoke.
Sensitivity analysis of signaling pathway models based on discrete-time measurements
Authors: Kardynska Malgorzata , Smieja Jaroslaw 
Published: June 2017

Abstract
The paper is focused on sensitivity analysis of large-scale models of biological systems that describe dynamics of the so called signaling pathways. These systems are continuous in time but their models are based on discrete-time measurements. Therefore, if sensitivity analysis is used as a tool supporting model development and evaluation of its quality, it should take this fact into account. Such models are usually very complex and include many parameters difficult to estimate in an experimental way. Changes of many of those parameters have little effect on model dynamics, and therefore they are called sloppy. In contrast, other parameters, when changed, lead to substantial changes in model responses and these are called stiff parameters. While this is a well-known fact, and there are methods to discern sloppy parameters from the stiff ones, they have not been utilized, so far, to create parameter rankings and quantify the influence of single parameter changes on system time responses. These single parameter changes are particularly important in analysis of signalling pathways, because they may pinpoint parameters, associated with the processes to be targeted at the molecular level in laboratory experiments. In the paper we present a new, original method of creating parameter rankings, based on an Hessian of a cost function which describes the fit of the model to a discrete experimental data. Its application is explained with simple dynamical systems, representing two typical dynamics exhibited by the signaling pathways.