bluuebunny/crossref_metadata_2025_split huggingface dataset:
One step cyclocondensation of (thio) barbituric acid with chalcones in glacial acetic acid and phosphorous pentoxide, Part-II
Authors: Akhter K , Halim ME , Ahmed SM , Sarkar PK , Akter F , Jahan K , Romman UKR , Ahmed MG 
Published: June 2017

A number of new 5, 7-diaryl-1,5-dihydro (or 1, 2, 3, 5-tetrahydro)- pyrano [2, 3-d] pyrimidin-2, 4-diones (or 2-thioxo-4-ones) (3a-g) have been synthesized in one-step by cyclocondensation of barbituric acid or thiobarbituric acid (1) with arylideneacetophenones (2a-d), in glacial acetic acid in the presence of phosphorous pentoxide. The structures of the compounds 3a-g have been determined by UV, IR, 1H NMR, 13C NMR, mass spectral data and elemental analyses. The compounds 3a-g do not seem to be available in the literature.Bangladesh J. Sci. Ind. Res. 52(2), 115-124, 2017
Gauge Dependence of Gravitational Waves Generated from Scalar Perturbations
Authors: Hwang Jai-chan , Jeong Donghui , Noh Hyerim 
Published: June 2017

Abstract
A tensor-type cosmological perturbation, defined as a transverse and traceless spatial fluctuation, is often interpreted as gravitational waves. While decoupled from the scalar-type perturbations in linear order, the tensor perturbations can be sourced from the scalar-type in nonlinear order. The tensor perturbations generated by the quadratic combination of a linear scalar-type cosmological perturbation are widely studied in the literature, but all previous studies are based on a zero-shear gauge without proper justification. Here, we show that, being second order in perturbation, such an induced tensor perturbation is generically gauge dependent. In particular, the gravitational wave power spectrum depends on the hypersurface (temporal gauge) condition taken for the linear scalar perturbation. We further show that, during the matter-dominated era, the induced tensor modes dominate over the linearly evolved primordial gravitational wave amplitude for

even for the gauge that gives the lowest induced tensor modes with the optimistic choice of primordial gravitational waves (r = 0.1). The induced tensor modes, therefore, must be modeled correctly specific to the observational strategy for the measurement of primordial gravitational waves from large-scale structure via, for example, the parity-odd mode of weak gravitational lensing, or clustering fossils.
Additions to the knowledge of Nevada carabid beetles (Coleoptera: Carabidae) and a preliminary list of carabids from the Great Basin National Park
Authors: Will Kipling , Madan Riva , Hsu Han 
Published: June 2017

Additions to the list of Carabidae known for Nevada, USA and carabid beetles found in the Great Basin National Park, NV are reported with notes on ecology and identification resources.
For 79 species of carabids, we present 57 new state records, two state records previously reported in online resources, one confirmation of a previous questionable record for the state, and report 22 records for the Great Basin National Park that includes three new state records.
L’évolution des polices municipales en France : une imitation des polices d’État vouée à l’échec ?
Authors: Mucchielli Laurent 
Published: June 2017

Les polices municipales font un retour remarqué sur la scène policière, dans l’organisation des municipalités et dans le débat public en France depuis les années 1980. Les effectifs cumulés des différentes catégories d’agents municipaux de sécurité dépassent désormais 30 000 personnes, réparties dans environ 3500 communes. Si cette évolution a correspondu à partir des années 1970 à une forte demande de police de proximité de la part des élus locaux, elle se poursuit de nos jours dans une dynamique souvent différente. Derrière un modèle « complémentariste » par rapport aux forces d’État, se profile dans de nombreuses villes un modèle « substitutif ». Ce dernier a été encouragé d’abord par certains maires ayant fortement politisé la question de la sécurité locale. Depuis le tournant sécuritaire des années 2000, amplifié encore par les attentats ayant frappé la France en 2015 et 2016, ce modèle substitutif est désormais encouragé à certains égards par l’État lui-même. Après avoir détaillé cette évolution, l’auteur examine le cas de la ville de Marseille, qui a opéré en 2012 une profonde réforme de sa police municipale, l’engageant volontairement dans le modèle substitutif. Il en propose un bilan montrant les limites de cette stratégie pour les municipalités.
L’humiliation sur Internet : Une nouvelle forme de cyberdélinquance ?
Authors: Dilmaç Julie Alev 
Published: June 2017

Dans cet article, il s’agit de s’interroger sur une nouvelle forme de cybercrime : l’humiliation sur Internet. Définie comme l’atteinte à la dignité de la personne par l’image, celle-ci tend à toucher toutes les tranches de la population. Or, si la cyberhumiliation présente les mêmes caractéristiques que l’humiliation traditionnelle, Internet semble y ajouter de nouveaux éléments et notamment l’impossibilité de répondre à l’affront. À partir d’un terrain effectué avec des jeunes adultes, il s’agit ici de cerner les visions liées à l’humiliation numérique et d’identifier les moyens employés par les individus en vue de se protéger d’une telle déviance. Nous verrons que l’émergence de ces stratégies individuelles n’est en fait que la conséquence de l’inefficacité des moyens préconisés par les autorités en vue d’éradiquer cette cyberdélinquance.
Une paraphrase du Notre Père dans les Actes apocryphes de Jean ? L’hypothèse d’A. Hamman revisitée
Authors: Paschke Boris 
Published: June 2017

Dans les Actes apocryphes de Jean ( ActJ ), un passage paraphrase le Notre Père . L’article confirme donc l’hypothèse formulée par Adalbert Gautier Hamman en 1963. Toutefois, étant donné que ActJ 75 n’est pas adressée au Père, mais à Jésus-Christ, elle étaye le « christomonisme » attribué aux Actes de Jean par la plupart des chercheurs. De plus, les parallèles entre cette prière et le Notre Père soulignent la notoriété que le Notre Père a eue dans le christianisme du ii e siècle.
La « centralité » de l’ASEAN : concept et mise en œuvre
Authors: Chalermpalanupap Termsak , Tarpinian Cécile 
Published: June 2017

Le concept de « centralité » de l’ASEAN a émergé il y a une dizaine d’années, alors que l’organisation semblait menacée par des projets concurrents. Différentes mesures ont été prises pour renforcer la solidité de l’Association mais sa pérennité n’est pas pour autant garantie. Elle souffre notamment d’un désintérêt des populations locales et d’un sous-financement chronique. Un nouveau traité de coopération politique permettrait de donner un second souffle à l’ASEAN.
A Distinct Inhibitory Function for miR-18a in Th17 Cell Differentiation
Authors: Montoya Misty M. , Maul Julia , Singh Priti B. , Pua Heather H. , Dahlström Frank , Wu Nanyan , Huang Xiaozhu , Ansel K. Mark , Baumjohann Dirk 
Published: June 2017

Abstract
Th17 cell responses orchestrate immunity against extracellular pathogens but also underlie autoimmune disease pathogenesis. In this study, we uncovered a distinct and critical role for miR-18a in limiting Th17 cell differentiation. miR-18a was the most dynamically upregulated microRNA of the miR-17–92 cluster in activated T cells. miR-18a deficiency enhanced CCR6+ RAR-related orphan receptor (ROR)γt+ Th17 cell differentiation in vitro and increased the number of tissue Th17 cells expressing CCR6, RORγt, and IL-17A in airway inflammation models in vivo. Sequence-specific miR-18 inhibitors increased CCR6 and RORγt expression in mouse and human CD4+ T cells, revealing functional conservation. miR-18a directly targeted Smad4, Hif1a, and Rora, all key transcription factors in the Th17 cell gene-expression program. These findings indicate that activating signals influence the outcome of Th cell differentiation via differential regulation of mature microRNAs within a common cluster.
The Challenges of Management of High-grade Gliomas in Nigeria
Authors: Ndubuisi Chika Anele , Mezue Wilfred C. , Nzegwu Martin , Okwunodulu Okwuoma , Ejembi Gabriel , Ohaegbulam Samuel C. 
Published: June 2017

ABSTRACT
Background: High-grade gliomas (HGG) are among the most challenging brain tumors despite many research efforts worldwide. Aim: The aim of this study was to evaluate the local challenges that may influence outcome of HGG managed in a neurosurgical center in Nigeria. Methodology: Retrospective analysis of prospectively recorded data of patients managed for intracranial HGG at Memfys Hospital for Neurosurgery, Enugu, Nigeria, between the year 2006 and 2015. Only cases with conclusive histology following surgery were analyzed. Results: Glioma was 60 (23.8%) of 252 histology confirmed brain tumors. HGG represented 53.8% of gliomas with male:female ratio of 2.2:1.0 and peaked from fifth decade of life. Glioblastoma multiforme accounted for 69% of HGG. At 1-year postsurgery, 53% of HGGs were dead and 88% of these deaths were in the World Health Organization Grade IV group. Only 40% of cases could receive adjuvant treatment with only 15% mortality at 1 year in this subgroup that received adjuvant therapy. In addition, 19% of cases had surgery at Karnofsky score (Ks) of ≤70%. However, 94% of mortality at 1 year was related to surgery at Ks of ≤60%. Only four patients had a tumor volume of ≤50 cm3, and among these cases, three patients were independent at 1 year. Patients with tumor volume above 50 cm3 accounted for 94% of mortality. Conclusion: The peak age incidence for HGG seems to be lower than in Caucasians. Most cases present late with poor Ks and big tumor volume. The proportion with access to adjuvant treatment is still poor. Preoperative Karnofsky, extent of resection, duration of hospital, and Intensive Care Unit stay have impact on outcome.
Isolated Intracranial Myeloid Sarcoma Occurring as Relapse in Acute Myeloid Leukemia
Authors: Narayanan Geetha , Soman Lali V. , Haridas Lakshmi , Sugathan Harish 
Published: June 2017

ABSTRACTMyeloid sarcoma (MS) or chloroma is a rare extramedullary tumor composed of extramedullary proliferation of blasts of granulocytic, monocytic, erythroid, or megakaryocytic lineage occurring at sites outside the bone marrow. MS occurs in 2%–8% of patients with acute myeloid leukemia (AML), sometimes it occurs as the presenting manifestation of relapse in a patient in remission. We describe the case of a young male with AML in remission for 6 years presenting with central nervous system symptoms. Magnetic resonance imaging showed an extra-axial altered intensity lesion in the parasagittal parietal region, infiltrating anterosuperiorly into anterior falx, and posterosuperior aspect of the superior sagittal sinus. A biopsy from the lesion was diagnostic of MS which was positive for myeloperoxidase. He did not have any other sites of disease. He has received chemotherapy with FLAG (Fludarabine, Cytosine arabinoside) followed by cranial irradiation and is in complete remission.
Reoperation in Spinal Dysraphism: Does it Help in Reversing the Neurological Deficits?
Authors: Maste Praful Suresh , Lokanath Yadhu Kasetti , Mahantshetti Shambhulingappa S. 
Published: June 2017

ABSTRACT
Aims: After initial primary repair by inexperienced hands for the spectrum of pathological conditions in spinal dysraphism (SD), a few percentage of patients present with recurrent symptoms and worsening neurological status especially when primarily pathology is not identified and dealt properly. When the primary intradural tethering element is left untouched, worsening of symptoms is common. In this retrospective study, we tried to analyze the symptomatology, functional outcome at 1–2 months after the second surgery and associated complications. Subjects and Methods: All patients underwent second surgery at author’s institution. Pre and post-operative data were evaluated using Necker –Enfants Malades (NEM) neurological and modified Hoffer ambulatory scale. Results: The main presenting complaints were bladder incontinence and limb weakness. Preoperative mean scores for motor and bladder were 3.56 and 2.78 out of 5, 2.67 out of 4, and 2.11 out of 3 for bowel and sensory function, respectively. Postoperative mean score for motor, sensory, bladder, and bowel function revealed good neurological improvement. Statistically neurological improvement in bladder and bowel function was significant. More than 60% of patients had normal ambulation at follow-up. Conclusions: Patients presenting with recurrent symptoms in an operated case of SD need to be investigated, cause of recurrence has to be identified, and if needed repeat surgery is recommended at the earliest. Long-standing neurological deficits can potentially improve, especially bladder and bowel function which gives a good quality of life to the patients. Furthermore, we want to stress the fact that since it is an intradural pathology, these cases should be operated by experienced neurosurgeons, and this fact should be made aware among referring doctors.
Predicting Prognosis of Psychosis in Huntington’s Disease: Case Report and Review of Literature
Authors: Kar Sujita Kumar , Shahi Mohit Kumar , Tripathi Adarsh , Sharma Praveen Kumar 
Published: June 2017

ABSTRACTHuntington’s disease (HD) is rare variant of progressive neurodegenerative disorder which follows an autosomal dominant pattern. Psychiatric comorbidities are not uncommon with HD. Mood disorder, cognitive disturbances, anxiety disorders, and psychosis are the psychiatric comorbidities reported with HD. We report here a case of HD, where psychosis developed during illness. Prognosis of psychosis in HD is emphasized in this report with review of literature.
Depression as a manifestation of obstructive sleep apnea
Authors: Shoib Sheikh , Malik Javid A. , Masoodi Shariq 
Published: June 2017

ABSTRACT
Background: Obstructive sleep apnea (OSA) often results in a wide range of comorbid conditions, predominantly of the cardiovascular/respiratory, endocrine/metabolic, and neuropsychiatric symptoms. In view of the ambiguity of literature regarding the association between OSA and depression, we conducted this study to show any association between the two disorders. Objective: The aim of the study was to see the association between OSA and depression and to study the prevalence of OSA in patients suffering from depression. Methods: We performed polysomnography (PSG) studies of patients that were referred from various subspecialty clinics from July 2011 to August 2013. Psychiatric diagnosis was done using mini international neuropsychiatric interview plus scale. This was followed by application of Hamilton Depression Rating Scale (HAM-D). Standard methods of statistical analysis were used for data analysis. Results: Out of 182 patients who underwent PSG, 47 were suffering from depression with a mean age significantly more (P < 0.001) than that of other population (58.60 years vs. 53.60 years). In our 47 depressed patients, 44 (93.6%) had abnormal PSG. Based on apnea-hypopnea index score, 3 (6.8%) patients had mild, 18 (40.9%) had moderate, and 23 (52.3%) had severe OSA. The mean HAM-D score was significantly more in depression patients, (17. 35 ± 5.45) as compared to non depressive patents (8.64 ± 6.24) (P = 0.0001). Conclusion: This study demonstrates significant overlap between the sleep apnea and depression. Health specialists need more information about screening for patients with OSA to ensure proper diagnosis and treatment of those with the condition. Most of the clinicians do not suspect this important comorbidity of depression in the beginning resulting in delayed diagnosis.
Late-onset Familial Amyloidotic Polyneuropathy with Bence Jones Proteinuria and Cardiomyopathy
Authors: García de León Sira Carrasco , González Amalia Hernández , Alonso Carmen Orellana , Lobo Laura Burriel 
Published: June 2017

ABSTRACTFamilial amyloidotic polyneuropathy is a genetically determined disease characterized by deposition of an anomalous transthyretin. A high index of suspicion is needed for this multisymptomatic and lethal disease to be diagnosed. The patient was a 70-year-old male examined due to hypesthesia in the hands and feet, plus difficulty walking. A neurophysiological study delivered the diagnosis of axonal sensorimotor polyneuropathy. He later developed cardiac symptoms and diarrhea. Urine laboratory analyses revealed a monoclonal spike of light chains (kappa). Biopsies of abdominal fat and bone marrow yielded normal results. The genetic study was compatible with a heterozygous Val30Met-transthyretin mutation. Very few case studies have described an association between familial amyloidotic polyneuropathy and monoclonal gammopathy. We stress that genetic confirmation is important regardless of the type of amyloid deposition revealed by the biopsy.
Reflection as a Learning Tool in Graduate Medical Education: A Systematic Review
Authors: Winkel Abigail Ford , Yingling Sandra , Jones Aubrie-Ann , Nicholson Joey 
Published: June 2017

ABSTRACT

Background
Graduate medical education programs employ reflection to advance a range of outcomes for physicians in training. However, the most effective applications of this tool have not been fully explored.

Objective
A systematic review of the literature examined interventions reporting the use of reflection in graduate medical education.

Methods
The authors searched Medline/PubMed, Embase, Cochrane CENTRAL, and ERIC for studies of reflection as a teaching tool to develop medical trainees' capacities. Key words and subject headings included reflection, narrative, residents/GME, and education/teaching/learning. No language or date limits were applied. The search yielded 1308 citations between inception for each database and June 15, 2015. A total of 16 studies, encompassing 477 residents and fellows, met eligibility criteria. Study quality was assessed using the Critical Appraisal Skills Programme Qualitative Checklist. The authors conducted a thematic analysis of the 16 articles.

Results
Outcomes studied encompassed the impact of reflection on empathy, comfort with learning in complex situations, and engagement in the learning process. Reflection increased learning of complex subjects and deepened professional values. It appears to be an effective tool for improving attitudes and comfort when exploring difficult material. Limitations include that most studies had small samples, used volunteers, and did not measure behavioral outcomes.

Conclusions
Critical reflection is a tool that can amplify learning in residents and fellows. Added research is needed to understand how reflection can influence growth in professional capacities and patient-level outcomes in ways that can be measured.
Hysterectomy by Vaginal Route: Not a Pressure
Authors: Vembu Radha , Dharmalingam Sithara 
Published: June 2017

ABSTRACT
Introduction
Vaginal route of hysterectomy is a safe procedure with less morbidity and hospital stay. So, there is a need to expand the indication for vaginal hysterectomy beyond uterovaginal prolapse.

Aims
To determine the feasibility and outcome of nondescent vaginal hysterectomy (NDVH) and to assess the pre- and postoperative complications, duration of surgery, and hospital stay.

Materials and methods
A prospective observational study was conducted between 2012 and 2014 at a tertiary care center. A total of 256 patients satisfying the selection criteria of hysterectomy for benign gynecological conditions, uterus size <16 weeks, and excluding stage IV endometriosis, genital tract malignancy, and uterine prolapse were included. The NDVH was performed by the standard technique, and the following parameters of age, parity, indication for surgery, duration of surgery, intraoperative and postoperative complications, and hospital stay were recorded. The data were analyzed using Statistical Package for the Social Sciences version 16.0 by frequency and percentage analysis and Chi-square test.

Results
All 256 patients were analyzed. The mean age was 44.4 ± 6.1 years; fibroid uterus was the commonest indication. About 89.4% had a uterine size ≤12 weeks and 59% had uterine volume <200 cm3. The mean duration of surgery was 83.5 ± 11.0 minutes; salpingo-oophorectomy was performed in 25.8% of the patients. Intraoperatively, 1.2% had bladder injury and 0.4% required conversion to laparotomy for pelvic hematoma. The mean duration of hospital stay was 4.9 ± 2.2 days, and the mean pain score in numerical rating scale pain scale was 3.0 ± 0.3. Intraoperative blood transfusion was required in 1.9% of the patients only.

Conclusion
The NDVH is a safe and feasible procedure for benign gynecological disorders.

Clinical significance
The NDVH is a boon in this techno-savvy era by reducing the morbidity and promising early return to work.

How to cite this article
Vembu R, Dharmalingam S. Hysterectomy by Vaginal Route: Not a Pressure. J South Asian Feder Menopause Soc 2017;5(1):8-10.
GPS – Zenith Total Delay assimilation in different resolution simulations of a heavy precipitation event over southern France
Authors: Caldas-Álvarez Alberto , Khodayar Samiro , Bock Olivier 
Published: June 2017

Abstract. The aim of this study is to investigate the different pathways of the interaction between an improved atmospheric moisture distribution by Data Assimilation (DA) of Global Positioning System Zenith Total Delays (GPS-ZTD) on the simulation of a selected Heavy Precipitation Event (HPE) across different model horizontal resolutions (7 km, 2.8 km and 500 m). The initiation and evolution of deep moist convection and heavy precipitation taking place on the 24 September 2012, which had a dedicated Intensive Observation Period (IOP6) during the Hydrological cycle in the Mediterranean eXperiment (HyMeX) Special Observation period 1, are analysed. The results show an improvement in the representation of the Integrated Water Vapour (IWV) spatial distribution and temporal evolution when the data assimilation is applied as well as through the refinement of the model grids. However, important discrepancies between the simulated and the observed vertical profiles of humidity still remain after the DA, thus affecting the representation of convection and heavy precipitation. For the presented case study, the model simulations exhibited a wet bias. The assimilation entailed a drying of the low to middle troposphere over the study region during the 6 h prior to the storm initiation for every horizontal resolution. This reduced the instability present at the moment of storm initiation, weakening in return the intensity of convection and the number of cells triggered. The improvement observed in the atmospheric moisture content and distribution was not followed by an improved precipitation representation closer to observations. This highlights the relevance of correctly distributing the assimilated IWV in the vertical direction in the models.
Implementação de orientações de enfermagem aos pacientes pré‑operatórios de cirurgia cardíaca em meio digital
Authors: Almeida Patrícia Silveira , Pellanda Lucia Campos , Caregnato Rita Catalina Aquino , De Souza Emiliane Nogueira 
Published: June 2017

Objetivo: Analisar a implementação das orientações de enfermagem aos pacientes pré‑operatórios de cirurgia de revascularização do miocárdio em meio digital. Método: Estudo de intervenção realizado em hospital de Porto Alegre, Rio Grande do Sul, utilizando método gerencial de processos, que tem como características: planejar, executar, verificar e avaliar. De agosto a setembro de 2015, os pacientes receberam orientações pré‑cirúrgicas por meio de um tablet. Resultados: Após orientações fornecidas, pacientes e enfermeiros avaliaram o uso da estratégia. Os dados foram analisados por estatística descritiva. Foram incluídos 27 pacientes, com idade média de 63,14±10,87 anos. Todos afirmaram ter aprendido mais a respeito da cirurgia e sobre o seu preparo. Também foram inseridas quatro enfermeiras, e todas afirmaram que a utilização do recurso audiovisual padronizou as informações transmitidas aos pacientes. Conclusão: A utilização do tablet favoreceu o entendimento dos pacientes pré‑cirúrgicos de cirurgia de revascularização do miocárdio e padronizou as orientações pré‑operatórias de enfermagem.