bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized controlled trial of emergency department initiated smoking cessation counselling and referral to a community counselling service
Authors: Cheung Ka Wai , Wong Ian WH. , Fingrut Warren , Tsai Amy Po Yu , Ke Sally R. , Shojaie Shayan , Brubacher Jeffrey R. , Stewart Lauren C. , Erdelyi Shannon 
Published: July 2017

AbstractObjectiveWorldwide, tobacco smoke is still the leading cause of preventable morbidity and mortality. Many smokers develop chronic smoking-related conditions that require emergency department (ED) visits. However, best practices for ED smoking cessation counselling are still unclear.MethodsA randomized controlled trial was conducted to determine whether an “ask, advise, and refer” approach increases 12-month, 30-day quit rates in the stable adult ED smoking population compared to usual care. Patients in the intervention group were referred to a community counselling service that offers a quitline, a text-based program, and a Web-based program. Longitudinal intention-to-treat analyses were performed.ResultsFrom November 2011 to March 2013, 1,295 patients were enrolled from one academic tertiary care ED. Six hundred thirty-five were allocated to usual care, and 660 were allocated to intervention. Follow-up data were available for 70% of all patients at 12 months. There was no statistically significant difference in 12-month, 30-day quit rates between the two groups. However, there was a trend towards higher 7-day quit attempts, 7-day quit rates, and 30-day quit rates at 3, 6, and 12 months in the intervention group.ConclusionIn this study, there was a trend towards increased smoking cessation following referral to a community counselling service. There was no statistically significant difference. However, if ED smoking cessation efforts were to provide even a small positive effect, such an intervention may have a significant public health impact given the extensive reach of emergency physicians.
All-terrain vehicle–related injuries and deaths in Newfoundland and Labrador between 2003 and 2013: a retrospective trauma registry review
Authors: Black Holly , Whalen Desmond , Alani Sabrina , Rogers Peter , MacLean Cathy 
Published: July 2017

AbstractBackgroundInjury and death involving all-terrain vehicles (ATV) has been reported in a number of Canadian provinces. The objective of this study is to describe the frequency, nature, severity, population affected, immediate health costs, efficacy of related legislation, and helmet use in ATV related injuries and deaths in Newfoundland and Labrador (NL).MethodsA retrospective review of injured or deceased ATV riders of all ages entered in the Newfoundland and Labrador Trauma Registry from 2003 to 2013 was conducted. Variables studied included demographics, injury type and severity, use of helmets, admission/discharge dates, and referring/receiving institution. Data was also obtained from the Newfoundland and Labrador Center for Health Information (NLCHI) and included all in-hospital deaths and hospitalizations due to ATVs between 1995 and 2013.ResultsThere were a total of 298 patients registered in the trauma registry, resulting in 2759 admission days, nine deaths, and a total estimated immediate healthcare system cost in excess of $1.6 million. More males (N=253, 84.9%) than females (N=45, 15.1%) were injured in ATV related incidents, t(20)=7.12, p<.0001. Head and thorax injuries were the most serious. 38.6% of patients were confirmed to be wearing helmets. Mean injury severity scores are as follows: head injury (M=11, SD=9.51), thorax (M=10, SD=8.3), abdominal/pelvis (M=9, SD=7.62), upper extremity (M=9, SD=8.53), other injuries (M=9, SD=10.56) lower extremity (M=8, SD=8.34), and spine (M=8, SD=6.52).ConclusionsThis study describes ATV related injuries and deaths in NL. Information from this study may guide physician practice, public education, and future legislation.
Patient Hand Colonization With MDROs Is Associated with Environmental Contamination in Post-Acute Care
Authors: Patel Payal K. , Mantey Julia , Mody Lona 
Published: July 2017

We assessed multidrug-resistant organism (MDRO) patient hand colonization in relation to the environment in post-acute care to determine risk factors for MDRO hand colonization. Patient hand colonization was significantly associated with environmental contamination. Risk factors for hand colonization included disability, urinary catheter, recent antibiotic use, and prolonged hospital stay.Infect Control Hosp Epidemiol 2017;38:1110–1113
Acquisition of Clostridium difficile Colonization and Infection After Transfer From a Veterans Affairs Hospital to an Affiliated Long-Term Care Facility
Authors: Ponnada Suresh , Guerrero Dubert M. , Jury Lucy A. , Nerandzic Michelle M. , Cadnum Jennifer L. , Alam M. Jahangir , Donskey Curtis J. 
Published: July 2017

BACKGROUNDClostridium difficile infection (CDI) and asymptomatic carriage of toxigenic C. difficile are common in long-term care facilities (LTCFs). However, whether C. difficile is frequently acquired in the LTCF versus during acute-care admissions remains unknown.OBJECTIVETo test the hypothesis that LTCF residents often acquire C. difficile colonization and infection in the LTCFDESIGNThis 5-month cohort study was conducted to determine the incidence of acquisition of C. difficile colonization and infection in asymptomatic patients transferred from a Veterans Affairs hospital to an affiliated LTCF.METHODSRectal swabs were cultured for toxigenic C. difficile at the time of transfer to the LTCF and weekly for up to 6 weeks. We calculated the proportion of LTCF-onset CDI cases within 1 month of transfer that occurred in residents colonized on admission versus those with new acquisition in the LTCF.RESULTSOf 110 patients transferred to the LTCF, 12 (11%) were asymptomatically colonized with toxigenic C. difficile upon admission, and 4 of these 12 patients (33%) developed CDI within 1 month, including 3 recurrent and 1 initial CDI episode. Of 82 patients with negative cultures on transfer and at least 1 follow-up culture, 22 (27%) acquired toxigenic C. difficile colonization, and 4 developed CDI within 1 month, including 1 recurrent and 3 initial CDI episodes.CONCLUSIONLTCF residents frequently acquired colonization with toxigenic C. difficile after transfer from the hospital, and 3 of 4 initial CDI cases with onset within 1 month of transfer occurred in residents who acquired colonization in the LTCF.Infect Control Hosp Epidemiol 2017;38:1070–1076
James Eadie Todd and the school of history at the Queen’s University of Belfast
Authors: Clarkson L. A. 
Published: July 2017

AbstractJames Eadie Todd was appointed to the chair of modern history in Queen’s University, Belfast in 1919, aged thirty-four, having previously held academic posts in Edinburgh, Montreal and Halifax, Nova Scotia. Todd published almost nothing but spent his career as a teacher, and his carefully prepared formal lectures guided generations of Queen’s students to a pass degree. But he also had the ability to inspire a minority of students to the further study of history and several of his pupils went on to occupy chairs of history in Ireland and Great Britain. During the 1930s, with his former pupil T. W. Moody, he created an honours and graduate school with a strong emphasis on Irish history. Todd stressed the importance of the objective study of the sources. Behind the scenes he was instrumental, with others, in founding the Ulster Society for Irish Historical Studies and establishing Irish Historical Studies. His later years were plagued by ill health and personal bereavement. He retired in 1945 and died four years later. The article concludes with an assessment of Todd’s importance to the professionalisation of Irish historical scholarship.
Being occupied: supporting ‘meaningful activity’ in care homes for older people in England
Authors: SMITH NICK , TOWERS ANN-MARIE , PALMER SINEAD , BEECHAM JENNIFER , WELCH ELIZABETH 
Published: July 2017

ABSTRACTThe benefits of meaningful activity in later life are well documented. Studies show that being occupied contributes to both physical and mental health as well as quality of life. Research also suggests that activity may be beneficial to people residing in care homes, including people living with dementia. This paper presents findings from a study which used the Adult Social Care Outcomes Toolkit (ASCOT) to measure quality of life in six care homes located in the south-east of England. The study found, like previous ones, that care home residents’ days were characterised by a lack of activity. Drawing on observations, interviews and focus groups with residents and staff from these homes, this paper attempts to understand why care home residents do not engage in meaningful activities. We reject the idea that these low levels of activity are a natural part of the ageing process or that they can be explained by notions of resident choice. Instead, the findings point to both insufficient funding and working practices within care homes as more substantive explanations. These explanations inform a discussion of how the low levels of engagement in meaningful activity could be addressed and residents’ quality of life improved.
Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial
Authors: Lindbergh Cutter A. , Renzi-Hammond Lisa M. , Hammond Billy R. , Terry Douglas P. , Mewborn Catherine M. , Puente Antonio N. , Miller L. Stephen 
Published: July 2017

AbstractObjectives:The present study constitutes the first randomized controlled trial to investigate the relation of lutein (L) and zeaxanthin (Z) to brain function using functional magnetic resonance imaging (fMRI). It was hypothesized that L and Z supplementation in older adults would enhance neural efficiency (i.e., reduce activation) and cognitive performance on a verbal learning task relative to placebo.Methods:A total of 44 community-dwelling older adults (mean age=72 years) were randomly assigned to receive either placebo or L+Z supplementation (12 mg/daily) for 1 year. Neurocognitive performance was assessed at baseline and post-intervention on an fMRI-adapted task involving learning and recalling word pairs. Imaging contrasts of blood-oxygen-level-dependent (BOLD) signal were created by subtracting active control trials from learning and recall trials. A flexible factorial model was employed to investigate the expected group (placebovs. supplement) by time (baselinevs. post-intervention) interaction in pre-specified regions-of-interest.Results:L and Z appeared to buffer cognitive decline on the verbal learning task (Cohen’sd=.84). Significant interactions during learning were observed in left dorsolateral prefrontal cortex and anterior cingulate cortex (p< .05, family-wise-error corrected). However, these effects were in the direction of increased rather than decreased BOLD signal. Although the omnibus interaction was not significant during recall, within-group contrasts revealed significant increases in left prefrontal activation in the supplement group only.Conclusions:L and Z supplementation appears to benefit neurocognitive function by enhancing cerebral perfusion, even if consumed for a discrete period of time in late life. (JINS, 2018,24, 77–90)
Organic farmer perceptions of reduced tillage: A Michigan farmer survey
Authors: Lowry Carolyn J. , Brainard Daniel C. 
Published: July 2017

AbstractA common critique of organic farming is that it is very tillage intensive, and therefore deleterious to soil quality. However, little information is available on the tillage practices currently employed by organic farmers, as well as organic farmers’ attitudes toward reduced tillage (RT). To address these knowledge gaps, a detailed written survey of Michigan organic field crop and vegetable farmers was conducted to investigate their current tillage practices, as well as their perceptions of the barriers and benefits to adoption of RT. Respondents reported a wide range in tillage frequency and intensity, both across and within production of specific crops, with operations split evenly between field preparation and cultivation. Compared with field crop growers, vegetable growers were generally smaller scale and relied more heavily on a limited set of tillage (e.g., rototiller) and cultivation tools. Interest in adoption of RT practices among respondents was low to moderate with median Likert scale ratings (0–7 scale with 0 representing no interest and 7 extreme interest) of 4 or less for all forms of RT. Vegetable growers were most interested in permanent beds, rotational tillage and strip tillage, whereas field crop growers were most interested in rotational tillage and strip tillage. The greatest perceived benefits to adoption of RT were improved soil quality and fuel savings. Both groups ranked weeds, impacts on yields, residue management and crop establishment as high barriers to RT adoption. Vegetable growers also cited lack of scale appropriate equipment as a major barrier. Survey results suggest that future research efforts should focus on overcoming key barriers to adoption, such as weed management and access to low-cost adaptable RT equipment rather than reiterating relatively well-known soil quality benefits. Our results also suggest that promotion of incremental reductions in the frequency and intensity of tillage operations on organic farms may be more realistic and equally valuable compared with promotion of more extreme forms of RT such as no-till.
Metagenomic binning of a marine sponge microbiome reveals unity in defense but metabolic specialization
Authors: Slaby Beate M , Hackl Thomas , Horn Hannes , Bayer Kristina , Hentschel Ute 
Published: July 2017

Abstract
Marine sponges are ancient metazoans that are populated by distinct and highly diverse microbial communities. In order to obtain deeper insights into the functional gene repertoire of the Mediterranean sponge Aplysina aerophoba, we combined Illumina short-read and PacBio long-read sequencing followed by un-targeted metagenomic binning. We identified a total of 37 high-quality bins representing 11 bacterial phyla and two candidate phyla. Statistical comparison of symbiont genomes with selected reference genomes revealed a significant enrichment of genes related to bacterial defense (restriction-modification systems, toxin-antitoxin systems) as well as genes involved in host colonization and extracellular matrix utilization in sponge symbionts. A within-symbionts genome comparison revealed a nutritional specialization of at least two symbiont guilds, where one appears to metabolize carnitine and the other sulfated polysaccharides, both of which are abundant molecules in the sponge extracellular matrix. A third guild of symbionts may be viewed as nutritional generalists that perform largely the same metabolic pathways but lack such extraordinary numbers of the relevant genes. This study characterizes the genomic repertoire of sponge symbionts at an unprecedented resolution and it provides greater insights into the molecular mechanisms underlying microbial-sponge symbiosis.
A neural link between generosity and happiness
Authors: Park Soyoung Q. , Kahnt Thorsten , Dogan Azade , Strang Sabrina , Fehr Ernst , Tobler Philippe N. 
Published: July 2017

AbstractGenerous behaviour is known to increase happiness, which could thereby motivate generosity. In this study, we use functional magnetic resonance imaging and a public pledge for future generosity to investigate the brain mechanisms that link generous behaviour with increases in happiness. Participants promised to spend money over the next 4 weeks either on others (experimental group) or on themselves (control group). Here, we report that, compared to controls, participants in the experimental group make more generous choices in an independent decision-making task and show stronger increases in self-reported happiness. Generous decisions engage the temporo-parietal junction (TPJ) in the experimental more than in the control group and differentially modulate the connectivity between TPJ and ventral striatum. Importantly, striatal activity during generous decisions is directly related to changes in happiness. These results demonstrate that top–down control of striatal activity plays a fundamental role in linking commitment-induced generosity with happiness.
Dual loss of human POLQ and LIG4 abolishes random integration
Authors: Saito Shinta , Maeda Ryo , Adachi Noritaka 
Published: July 2017

AbstractHomologous recombination-mediated gene targeting has greatly contributed to genetic analysis in a wide range of species, but is highly inefficient in human cells because of overwhelmingly frequent random integration events, whose molecular mechanism remains elusive. Here we show that DNA polymerase θ, despite its minor role in chromosomal DNA repair, substantially contributes to random integration, and that cells lacking both DNA polymerase θ and DNA ligase IV, which is essential for non-homologous end joining (NHEJ), exhibit 100% efficiency of spontaneous gene targeting by virtue of undetectable levels of random integration. Thus, DNA polymerase θ-mediated end joining is the sole homology-independent repair route in the absence of NHEJ and, intriguingly, their combined absence reveals rare Alu-Alu recombination events utilizing a stretch of homology. Our findings provide new insights into the mechanics of foreign DNA integration and the role of DNA polymerase θ in human genome maintenance.
Reciprocal carbonyl–carbonyl interactions in small molecules and proteins
Authors: Rahim Abdur , Saha Pinaki , Jha Kunal Kumar , Sukumar Nagamani , Sarma Bani Kanta 
Published: July 2017

AbstractCarbonyl-carbonyl n→π* interactions where a lone pair (n) of the oxygen atom of a carbonyl group is delocalized over the π* orbital of a nearby carbonyl group have attracted a lot of attention in recent years due to their ability to affect the 3D structure of small molecules, polyesters, peptides, and proteins. In this paper, we report the discovery of a “reciprocal” carbonyl-carbonyl interaction with substantial back and forth n→π* and π→π* electron delocalization between neighboring carbonyl groups. We have carried out experimental studies, analyses of crystallographic databases and theoretical calculations to show the presence of this interaction in both small molecules and proteins. In proteins, these interactions are primarily found in polyproline II (PPII) helices. As PPII are the most abundant secondary structures in unfolded proteins, we propose that these local interactions may have implications in protein folding.
Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization
Authors: Mazza Giuseppe , Al-Akkad Walid , Telese Andrea , Longato Lisa , Urbani Luca , Robinson Benjamin , Hall Andrew , Kong Kenny , Frenguelli Luca , Marrone Giusi , Willacy Oliver , Shaeri Mohsen , Burns Alan , Malago Massimo , Gilbertson Janet , Rendell Nigel , Moore Kevin , Hughes David , Notingher Ioan , Jell Gavin , Del Rio Hernandez Armando , De Coppi Paolo , Rombouts Krista , Pinzani Massimo 
Published: July 2017

AbstractThe development of human liver scaffolds retaining their 3-dimensional structure and extra-cellular matrix (ECM) composition is essential for the advancement of liver tissue engineering. We report the design and validation of a new methodology for the rapid and accurate production of human acellular liver tissue cubes (ALTCs) using normal liver tissue unsuitable for transplantation. The application of high shear stress is a key methodological determinant accelerating the process of tissue decellularization while maintaining ECM protein composition, 3D-architecture and physico-chemical properties of the native tissue. ALTCs were engineered with human parenchymal and non-parenchymal liver cell lines (HepG2 and LX2 cells, respectively), human umbilical vein endothelial cells (HUVEC), as well as primary human hepatocytes and hepatic stellate cells. Both parenchymal and non-parenchymal liver cells grown in ALTCs exhibited markedly different gene expression when compared to standard 2D cell cultures. Remarkably, HUVEC cells naturally migrated in the ECM scaffold and spontaneously repopulated the lining of decellularized vessels. The metabolic function and protein synthesis of engineered liver scaffolds with human primary hepatocytes reseeded under dynamic conditions were maintained. These results provide a solid basis for the establishment of effective protocols aimed at recreating human liver tissue in vitro.
Differential electron emission from polycyclic aromatic hydrocarbon molecules under fast ion impact
Authors: Biswas Shubhadeep , Champion Christophe , Weck P. F. , Tribedi Lokesh C. 
Published: July 2017

AbstractInteraction between polycyclic aromatic hydrocarbon (PAH) molecule and energetic ion is a subject of interest in different areas of modern physics. Here, we present measurements of energy and angular distributions of absolute double differential electron emission cross section for coronene (C24H12) and fluorene (C13H10) molecules under fast bare oxygen ion impact. For coronene, the angular distributions of the low energy electrons are quite different from that of simpler targets like Ne or CH4, which is not the case for fluorene. The behaviour of the higher electron energy distributions for both the targets are similar to that for simple targets. In case of coronene, a clear signature of plasmon resonance is observed in the analysis of forward-backward angular asymmetry of low energy electron emission. For fluorene, such signature is not identified probably due to lower oscillator strength of plasmon compared to the coronene. The theoretical calculation based on the first-order Born approximation with correct boundary conditions (CB1), in general, reproduced the experimental observations qualitatively, for both the molecules, except in the low energy region for coronene, which again indicates the role of collective excitation. Single differential and total cross sections are also deduced. An overall comparative study is presented.
Barcoding utility in a mega-diverse, cross-continental genus: keeping pace with Cyrtodactylus geckos
Authors: Brennan Ian G. , Bauer Aaron M. , Van Tri Ngo , Wang Yun-yu , Wang Wen-zhi , Zhang Ya-Ping , Murphy Robert W. 
Published: July 2017

AbstractOver the past decade, DNA barcoding has become a staple of low-cost molecular systematic investigations. The availability of universal primers and subsidized sequencing projects (PolarBOL, SharkBOL, SpongeBOL) have driven this popularity, often without appropriate investigation into the utility of barcoding data for the taxonomic group of interest. Here, our primary aim is to determine the phylogenetic value of DNA barcoding (mitochondrial locus COI) within the gecko genus Cyrtodactylus. With >40 new species described since last systematic investigation, Cyrtodactylus represents one of the most diverse extant squamate genera, and their contemporary distribution spans the Indian subcontinent, eastward through Indochina, and into AustraloPapua. The complex biogeographic history of this group, and morphology-only designation of many species have complicated our phylogenetic understanding of Cyrtodactylus. To highlight the need for continued inclusive molecular assessment, we use Vietnamese Cyrtodactylus as a case study showing the geopolitically paraphyletic nature of their history. We compare COI to the legacy marker ND2, and discuss the value of COI as an interspecific marker, as well as its shortcomings at deeper evolutionary scales. We draw attention back to the Cold Code as a subsidized method for incorporating molecular methods into species descriptions in the effort to maintain accurate phylogenies.