bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of 3′,4′‐Diaryl‐4′H‐spiro[indoline‐3,5′‐[1′,2′,4′]oxadiazol]‐2‐ones via DMAP‐Catalyzed Domino Reactions and Their Antibacterial Activity.
Authors: Shi Guanghao , He Xinwei , Shang Yongjia , Xiang Liwei , Yang Cheng , Han Guang , Du Bing 
Published: December 2016

AbstractThe entitled reaction proceeds via a 1,3‐dipolar cycloaddition reaction of imines into aryl nitrile oxides.
ChemInform Abstract: Direct Access to 2‐Amino‐5‐azidomethylfurans Through Palladium‐Catalyzed Azidative Cycloisomerization of Homoallenyl Amides.
Authors: Huang Qianwen , Zheng Hanliang , Liu Shuiyou , Kong Lichun , Luo Fang , Zhu Gangguo 
Published: December 2016

AbstractA novel azidative cycloisomerization of homoallenyl amides (I) and (III) using TmsN3 as the azidation reagent and a hypervalent iodine reagent as the oxidant giving a series of azidomethyl‐furans (II) and (IV), resp., is presented.
ChemInform Abstract: The Synthesis of Multisubstituted Pyrroles via a Copper‐Catalyzed Tandem Three‐Component Reaction.
Authors: Mou Xue‐Qing , Xu Zheng‐Liang , Xu Li , Wang Shao‐Hua , Zhang Bang‐Hong , Zhang Di , Wang Jie , Liu Wei‐Ting , Bao Wen 
Published: December 2016

AbstractA nucleophilic addition/cyclization/aromatization cascade of aromatic alkenes/alkynes, trimethylsilyl cyanide, and N,N‐disubstituted formamides gives pyrroles in moderate to good yields with high regioselectivities.
ChemInform Abstract: AgI‐Promoted Cascade for Difluoromethylation of Activated Alkenes to Difluoromethylated Oxindoles.
Authors: Wang Xinglu , Wan Wen , Chen Yunrong , Li Jialiang , Jiang Haizhen , Wang Yong , Deng Hongmei , Hao Jian 
Published: December 2016

AbstractIn this new Ag(I)‐promoted reaction between N‐arylacrylamides and ethyl trimethylsilyldifluoroacetate, the corresponding 3‐(2‐ethoxycarbonyl‐2,2‐difluoroethyl)‐2‐oxo‐2,3‐dihydro‐1H‐indoles have been prepared in good yields.
ChemInform Abstract: Lewis Acid Catalyzed Displacement of Trichloroacetimidates in the Synthesis of Functionalized Pyrroloindolines.
Authors: Adhikari Arijit A. , Chisholm John D. 
Published: December 2016

AbstractSeveral C‐3a‐substituted pyrroloindolines are obtained by nucleophilic substitution reaction of appropriate pyrroloindolinol trichloroacetimidates utilizing anilines, alcohols, thiols, and carbon nucleophiles.
ChemInform Abstract: Alkaloid‐Catalyzed Enantioselective [3 + 2] Cycloaddition of Ketenes and Azomethine Imines.
Authors: Mondal Mukulesh , Wheeler Kraig A. , Kerrigan Nessan J. 
Published: December 2016

AbstractAn asymmetric formal cycloaddition of in situ generated ketenes and azomethine imines provides bicyclic pyrazolidinones in good to excellent yields with good to excellent diastereoselectivity and excellent enantioselectivity.
ChemInform Abstract: Microwave‐Accelerated and Catalyst‐Free Synthesis of Novel tris‐(Pyrazolyl)methanes.
Authors: Beyrati Maryam , Hasaninejad Alireza 
Published: December 2016

AbstractThe title compounds are prepared by condensation of pyrazolecarbaldehydes, hydrazines, and β‐ketoesters in high yields.
ChemInform Abstract: Iodine‐Mediated Aryl C—H Amination for the Synthesis of Benzimidazoles and Pyrido[1,2‐a]benzimidazoles.
Authors: Lv Zhigang , Liu Jing , Wei Wei , Wu Jie , Yu Wenquan , Chang Junbiao 
Published: December 2016

AbstractAn iodine mediated intramolecular C—H amination of N‐2‐pyridyl substituted electron rich anilines is developed to produce pyrido[1,2‐a]benzimidazoles in good yields, in general.
ChemInform Abstract: Simple but Efficient Synthesis of Novel Substituted Benzimidazoles over ZrO2‐Al2O3.
Authors: Thimmaraju N. , Shamshuddin S. Z. Mohamed , Pratap S. R. , Raja K. , Shyamsundar M. , Mohankumar T. E. 
Published: December 2016

AbstractThe ZrO2—Al2O3 solid acid catalytic material is found to be highly active, recyclable and reusable in the entitled formation of benzimidazoles (III).
ChemInform Abstract: 5‐Hydroxyl Hydantoins via One‐Pot Microwave‐Assisted Air Oxidation of Ugi Products.
Authors: Huang Adrian , Wo Kellie , Pierson Allene , Lee So Yeun Christine , Yang Erin , Johnson Catherine 
Published: December 2016

Abstract11 Hydantoin derivatives are prepared by cyclization of the product of a five‐component Ugi‐type reaction.
ChemInform Abstract: An Efficient Four‐Component Approach for the Synthesis of Novel 5‐Methyl‐4‐(2‐ (3‐methyl‐4‐nitroisoxazol‐5‐yl)‐1‐arylethyl)‐1H‐pyrazol‐3‐ol Derivatives and Their Antibacterial Study.
Authors: Muthineni Narmada , Satish Kumar Nandigama , Chandrasekhara Rao L. , Dileep Kumar V. , Misra Sunil , Raju Chowhan L. , Meshram H. M. 
Published: December 2016

AbstractTitle compounds have been prepared via 4‐component reaction of hydrazine hydrate, ethyl aceto/benzoyl‐acetate ((I) or (VII)), 3,5‐dimethyl‐4‐nitro‐isoxazole (II) and (het)arylaldehydes ((III) and (V)) including 1‐phenyl‐3‐arylpyrazol‐4‐carbaldehydes (IX).
ChemInform Abstract: Exploration and Optimization of an Efficient One‐Pot Sequential Synthesis of Di/Tri‐Substituted Thiazoles from α‐Bromoketones, Thioacids Salt, and Ammonium Acetate.
Authors: Venkateswararao Eeda , Jalani Hitesh B. , Manoj Manickam , Jung Sang‐Hun 
Published: December 2016

Abstract24 Substituted thiazoles of type (III)/(V) are prepared by an optimized one‐pot two‐step procedure.
ChemInform Abstract: Synthesis of Diverse Benzotriazoles from Aryne Precursors Bearing an Azido Group via Inter‐ and Intramolecular Cycloadditions.
Authors: Yoshida Suguru , Morita Takamoto , Hosoya Takamitsu 
Published: December 2016

AbstractStarting from 3‐(azidoalkoxy)aryne precursor, a diverse range of bis‐1,2,3‐triazoles (IV) are obtained via a sequential azide‐alkyne and azide‐aryne cycloaddition, while unique ring‐fused benzotriazoles (VI) are obtained via an intramolecular azido‐aryne cycloaddition.
ChemInform Abstract: Regioselective Synthesis of Bifuroxanyl Systems with the 3‐Nitrobifuroxanyl Core via a One‐Pot Acylation/Nitrosation/Cyclization Cascade.
Authors: Fershtat Leonid L. , Larin Alexander A. , Epishina Margarita A. , Kulikov Alexander S. , Ovchinnikov Igor V. , Ananyev Ivan V. , Makhova Nina N. 
Published: December 2016

AbstractThe title reaction involves the acylation of the sodium salt (II) of dinitromethan with furoxanyl hydroxamic acid chlorides, nitrosation of the resulting product, and subsequent cyclization by slight increase of temperature.
ChemInform Abstract: The Acid and/or Thermal Mediated Ring Contraction of 4H‐1,2,6‐Thiadiazines to Afford 1,2,5‐Thiadiazoles.
Authors: Kalogirou Andreas S. , Kourtellaris Andreas , Koutentis Panayiotis A. 
Published: December 2016

AbstractRing contraction of 1,2,6‐thiadiazin‐4‐one 1,2‐phenylene ketals affords 3‐(benzo[d][1,3]dioxol‐2‐ylmethyl)‐1,2,5‐thiadiazoles.
ChemInform Abstract: Amino Acid Ligands for Ruthenium(II)‐Catalyzed C—H Arylation of Aryltetrazoles with Chlorides: Expedient Access to Antihypertension Drugs.
Authors: Hubrich Jonathan , Ackermann Lutz 
Published: December 2016

AbstractUsing N‐pivaloyl‐L‐valine as the ligand and 1‐benzyltetrazol‐5‐yl group as the directing group regioselective ortho‐arylation of benzyltetrazolyl‐benzenes with (het)aryl halides has been achieved in good yields.
ChemInform Abstract: Glycerol Mediated Green and One‐Pot Synthesis of 6‐Amino‐1,4‐dihydropyrano[2,3‐c]‐pyrazole‐5‐carbonitriles under Catalyst Free Conditions.
Authors: Vekariya Rajesh H. , Patel Hitesh D. 
Published: December 2016

AbstractThe method proceeds in a green reaction media under mild and catalyst‐free reaction conditions.
ChemInform Abstract: An Efficient Solvent‐Free Synthesis of Isoxazolyl‐1,4‐dihydropyridines on Solid Support SiO2 under Microwave Irradiation.
Authors: Zhang Dawei , Chen Xiaodong , Guo Xue , Zhang Yumin , Hou Yaya , Zhao Tianqi , Gu Qiang 
Published: December 2016

Abstractvia a multicomponent reaction strategy
ChemInform Abstract: Synthesis of 2,4,6‐Trisubstituted Pyridines by Oxidative Eosin Y Photoredox Catalysis.
Authors: Rohokale Rajendra S. , Koenig Burkhard , Dhavale Dilip D. 
Published: December 2016

AbstractThe title reaction between acetophenone derivatives and benzylamines delivers various 2,4,6‐trisubstituted pyridines moderate to high yields.
ChemInform Abstract: Metal‐Free C(sp3)—H Oxidation of 2‐Methylquinolines with PIDA under Microwave Irradiation.
Authors: Jiang Long , Huang Yingyi , Yan Yiyan , Xie Yuanyuan 
Published: December 2016

AbstractThe title process allows the conversion of 2‐methylquinolines to aldehydes in high yields.
ChemInform Abstract: Sulfonic Acid—Functionalized Wang Resin (Wang‐OSO3H) as Polymeric Acidic Catalyst for the Ecofriendly Multicomponent Synthesis of Polyhydroquinolines via Hantzsch Condensation.
Authors: Dhanunjaya Rao A. V. , et al.  
Published: December 2016

AbstractIn the title reaction, the Wang sulfonic acid acts as a very efficient and green promoter.
ChemInform Abstract: A Facile Preparation of Imidazo[1,2‐a]pyridin‐3‐amine Derivatives via a Three‐Component Reaction with β‐Cyclodextrin—SO3H as Catalyst.
Authors: Wu Jian , Xu Fang‐Zhou , Feng She‐Lei , Xue Wei , Wang Zhen‐Zhen 
Published: December 2016

AbstractA facile β‐cyclodextrin‐SO3H catalyzed three‐component cyclization of aromatic aldehydes, 2‐pyridylamine, and isocyanides affords imidazo[1,2‐a]pyridin‐3‐amines.
ChemInform Abstract: An Expedient Synthesis and anti‐Microbial Evaluation of Ethoxyphthalimido Derivatives of Pyrimido[4,5‐e]pyrimidine Analogues from 1‐(1H‐Benzimidazol‐2‐yl)guanidine.
Authors: Prajapat Prakash , Kumawat Monika , Kherodiya Bhawana , Talesara Lal Ganpat 
Published: December 2016

AbstractSome of the new compounds, e.g. (Xd), exhibit high antibacterial and antifungal activity similar to the reference drugs.
ChemInform Abstract: PTSA‐Catalyzed One‐Pot Synthesis of Quinoxalines Using DMSO as the Oxidant.
Authors: Zhang Zeyuan , Xie Caixia , Feng Lei , Ma Chen 
Published: December 2016

AbstractAn efficient TosOH‐catalyzed, one‐pot, two‐step oxidative system for the cyclization of o‐diaminobenzene with 1,2‐diaryl‐2‐hydroxyethanone to quinoxalines (III) is described.
ChemInform Abstract: Electrophile‐Induced Cyclization of 3‐Alkynyl‐2‐arylquinoxalines: A Method for Benzo‐ and Naphthophenazine Synthesis.
Authors: Gulveskaya Anna V. 
Published: December 2016

AbstractA facile synthesis of benzo[a]‐, naphtho[1,2‐a]‐ and naphtho[2,1‐a]phenazines by ICl‐promoted 6‐endo‐dig cyclization of 3‐alkynyl‐2‐arylquinoxalines is developed.
ChemInform Abstract: A Selective RhI‐Catalyzed Substrate‐Controlled C—C Bond Activation of Benzyl Sulfonamide/Alcohol‐Tethered Alkylidenecyclopropanes.
Authors: Chen Kai , Liu Jia‐Xin , Tang Xiang‐Ying , Shi Min 
Published: December 2016

AbstractThe title method offers access to three structural motifs, namely benzo[c]azepines/oxepines, dihydronaphthalen‐1‐amines and conjugated dienes.
ChemInform Abstract: A Practical Synthesis of 4‐Amino‐2‐methyl‐10H‐thieno[2,3‐b][1,5]benzodiazepine.
Authors: Ye Ping‐Ping , Liu Ning , Chang Yu‐Wei , Xu Wei‐Ming 
Published: December 2016

AbstractThe title compound (II), a key intermediate for the synthesis of the anti‐psychotic drug olanzapine, is prepared by intramolecular cyclocondensation of [(nitrophenyl)amino]thiophenecarbonitrile (I) using tin powder and HCl a reducing system.
ChemInform Abstract: 1,1‐Dibromoalkenes as Versatile Reagents to a Transition Metal‐Free and Stereoselective Synthesis of (E)‐1‐Bromo‐1‐selenoalkenes and Ketene Selenoacetals.
Authors: Webber Rodrigo , Peglow Thiago J. , Nobre Patrick C. , Barcellos Angelita M. , Roehrs Juliano A. , Schumacher Ricardo F. , Perin Gelson 
Published: December 2016

AbstractThe reaction of dibromoalkenes (I) with diselenides is controlled by stoichiometry and temperature to allow the selective formation of (E)‐1‐bromo‐1‐selenoalkenes (III) or ketene selenoacetals (IV).
ChemInform Abstract: Stachartins A—E, Phenylspirodrimanes from the Tin Mine Tailings‐Associated Fungus Stachybotrys chartarum.
Authors: Chunyu Wei‐Xun , Ding Zhang‐Gui , Li Ming‐Gang , Zhao Jiang‐Yuan , Gu Shao‐Jie , Gao Yuan , Wang Fei , Ding Jian‐Hai , Wen Meng‐Liang 
Published: December 2016

Abstractisolation and structure elucidation
ChemInform Abstract: Campyridones A—D, Pyridone Alkaloids from a Mangrove Endophytic Fungus Campylocarpon sp. HDN13‐307.
Authors: Zhu Meilin , Zhang Xiaomin , Feng Huimin , Che Qian , Zhu Tianjiao , Gu Qianqun , Li Dehai 
Published: December 2016

Abstractisolation, structure elucidation, cytotoxicity and biosynthetic pathway
Proximity‐Dependent Biotinylation for Identification of Interacting Proteins
Authors: Le Sage Valerie , Cinti Alessandro , Mouland Andrew J. 
Published: December 2016

AbstractComplex interaction networks orchestrate key cellular processes including but not limited to transcription, translation, metabolism, and cell signaling. Delineating these interactions will aid in deciphering the regulation and function of these pathways and potential for manipulation. Proximity‐dependent biotin identification (BioID) is quickly gaining popularity as a powerful tool for identifying novel protein‐protein and proximity‐based interactions in live cells. This technique relies on a promiscuous biotin ligase, which is fused to a protein of interest and, upon expression in the desired cell, will biotinylate proximal endogenous proteins. In vivo protein‐protein interactions can be very transient and occur momentarily to facilitate signaling or a metabolic function. BioID is useful in identifying these weak and/or transient interactions that are not detected by traditional methods such as yeast two‐hybrid or affinity purification. Here, we outline a BioID protocol that can be used as a workflow to guide a new application. © 2016 by John Wiley & Sons, Inc.
Measurement of Behavioral Taste Responses in Mice: Two‐Bottle Preference, Lickometer, and Conditioned Taste‐Aversion Tests
Authors: Gaillard Dany , Stratford Jennifer M. 
Published: December 2016

AbstractThe natural like and dislike of foods based on taste is one of the most easily observed behaviors in animals. Animals eat palatable foods and reject aversive foods, which makes measurement of taste perception possible using various behavioral techniques. Three different methods to accurately measure taste behavior are described here. First, two‐bottle preference tests evaluate whether a taste compound (tastant) is preferred over water. Second, lickometer tests quantify the like and dislike for multiple concentrations of the same tastant or multiple tastants at the same time. Finally, conditioned taste aversion tests accurately determine the perceived taste threshold for palatable tastants. Together, these diverse methods enable researchers to observe and measure behavioral taste responses in mice to any tastant. © 2016 by John Wiley & Sons, Inc.
Determining Functional Aptamer‐Protein Interaction by Biolayer Interferometry
Authors: Lou Xinhui , Egli Martin , Yang Xianbin 
Published: December 2016

AbstractShort single‐stranded nucleic acids called aptamers are widely being explored as recognition molecules of high affinity and specificity for binding a wide range of target molecules, particularly protein targets. In biolayer interferometry (BLI), a simple Dip‐and‐Read approach in which the aptamer‐coated biosensors are dipped into microplate wells is used to study the interactions between an aptamer and its target protein. Here we describe the protocol for the analysis of the interaction between a well‐characterized anti‐thrombin RNA aptamer with thrombin (Basic Protocol). We also report on the protocol for the affinity screening of a panel of anti‐thrombin RNA aptamers with a single phosphorodithioate (PS2) modification, whereby the position of the modification along the RNA backbone is varied systematically (Support Protocol). The PS2 modification uses two sulfur atoms to replace two non‐bridging oxygen atoms at an internucleotide phosphodiester backbone linkage. The PS2‐modified RNAs are nuclease resistant and several in vitro and in vivo assays have demonstrated their biological activity. For example, combining the PS2 with the 2′‐OMe modification affords increased loading of modified small interfering RNA (siRNA) duplexes into the RNA‐induced silencing complex (RISC) as well as enhanced gene‐silencing antitumor activity. © 2016 by John Wiley & Sons, Inc.
Gram‐Scale Chemical Synthesis of Base‐Modified Ribonucleoside‐5′‐O‐Triphosphates
Authors: Shanmugasundaram Muthian , Senthilvelan Annamalai , Kore Anilkumar R. 
Published: December 2016

AbstractThis unit delineates a simple, reliable, straight‐forward, general, and efficient chemical method for the synthesis of modified nucleoside‐5′‐O‐triphosphates such as 5‐methylcytidine‐5′‐O‐triphosphate (5‐Me‐CTP), pseudouridine‐5′‐O‐triphosphate (pseudo‐UTP), and N
1‐methylpseudouridine‐5′‐O‐triphosphate (N
1‐methylpseudo‐UTP), starting from the corresponding nucleoside. The reaction utilizes an improved protection‐free “one‐pot, three‐step” Ludwig synthetic strategy that involves the monophosphorylation of the nucleoside with phosphorous oxychloride followed by reaction with tributylammonium pyrophosphate and subsequent hydrolysis of the resulting cyclic intermediate to furnish the corresponding ribonucleoside triphosphate (NTP) in moderate yields. It is noteworthy that the reaction affords high purity (>99.5%) NTPs after DEAE Sepharose column purification. © 2016 by John Wiley & Sons, Inc.
Waste‐to‐Chemicals for a Circular Economy: The Case of Urea Production (Waste‐to‐Urea)
Authors: Antonetti Elena , Iaquaniello Gaetano , Salladini Annarita , Spadaccini Luca , Perathoner Siglinda , Centi Gabriele 
Published: December 2016

AbstractThe economics and environmental impact of a new technology for the production of urea from municipal solid waste, particularly the residue‐derived fuel (RdF) fraction, is analyzed. Estimates indicate a cost of production of approximately €135 per ton of urea (internal rate of return more than 10 %) and savings of approximately 0.113 tons of CH4 and approximately 0.78 tons of CO2 per ton of urea produced. Thus, the results show that this waste‐to‐urea (WtU) technology is both economically valuable and environmentally advantageous (in terms of saving resources and limiting carbon footprint) for the production of chemicals from municipal solid waste in comparison with both the production of urea with conventional technology (starting from natural gas) and the use of RdF to produce electrical energy (waste‐to‐energy). A further benefit is the lower environmental impact of the solid residue produced from RdF conversion. The further benefit of this technology is the possibility to realize distributed fertilizer production.
Catalyst and Process Design for the Continuous Manufacture of Rare Sugar Alcohols by Epimerization–Hydrogenation of Aldoses
Authors: Lari Giacomo M. , Gröninger Olivier G. , Li Qiang , Mondelli Cecilia , López Núria , Pérez‐Ramírez Javier 
Published: December 2016

AbstractInvited for this month′s cover are the groups of Javier Pérez‐Ramírez at ETH Zurich and of Núria López at Barcelona Institute of Science and Technology. The image shows a samba singer and dancer shouting “Azúcar!” (Spanish for sugar), which symbolizes the message of their Full Paper dealing with sugar upgrading. The Full Paper itself is available at 10.1002/cssc.201600755.
Multiscale habitat relationships of snowshoe hares (Lepus americanus) in the mixed conifer landscape of theNorthernRockies,USA: Cross‐scale effects of horizontal cover with implications for forest management
Authors: Holbrook Joseph D. , Squires John R. , Olson Lucretia E. , Lawrence Rick L. , Savage Shannon L. 
Published: December 2016

AbstractSnowshoe hares (Lepus americanus) are an ecologically important herbivore because they modify vegetation through browsing and serve as a prey resource for multiple predators. We implemented a multiscale approach to characterize habitat relationships for snowshoe hares across the mixed conifer landscape of the northern Rocky Mountains,USA. Our objectives were to (1) assess the relationship between horizontal cover and snowshoe hares, (2) estimate how forest metrics vary across the gradient of snowshoe hare use and horizontal cover, and (3) model and map snowshoe hare occupancy and intensity of use. Results indicated that both occupancy and intensity of use by snowshoe hares increased with horizontal cover and that the effect became stronger as intensity of use increased. This underscores the importance of dense horizontal cover to achieve high use, and likely density, of snowshoe hares. Forest structure in areas with high snowshoe hare use and horizontal cover was characterized as multistoried with dense canopy cover and medium‐sized trees (e.g., 12.7–24.4 cm). The abundance of lodgepole pine (Pinus contorta) was associated with snowshoe hare use within a mixed conifer context, and the only species to increase in abundance with horizontal cover wasEngelmann spruce (Picea engelmannii) and subalpine fir (Abies lasiocarpa). Our landscape‐level modeling produced similar patterns in that we observed a positive effect of lodgepole pine and horizontal cover on both occupancy and use by snowshoe hares, but we also observed a positive yet parabolic effect of snow depth on snowshoe hare occupancy. This work is among the first to characterize the multiscale habitat relationships of snowshoe hares across a mixed conifer landscape as well as to map their occupancy and intensity of use. Moreover, our results provide stand‐ and landscape‐level insights that directly relate to management agencies, which aids in conservation efforts of snowshoe hares and their associated predators.
The Electric Discharge Detection Method in the Low Vacuum Region of Vacuum Interrupter
Authors: ABE JUNICHI , TANABE TOMOKO , YANO TOMOTAKA , YOSHIDA SATORU , INOUE NAOAKI 
Published: December 2016

SUMMARYThe vacuum circuit breaker (VCB) achieves the high current interrupting capability in the pressure lower than 10 Pa to 5 Pa. When gas pressure increases, the breakdown voltage of a VCB decreases according to Paschen's law, and in the case of small leak, the partial discharge will occur in the VCB and the high frequency electromagnetic waves are radiated. So, we have developed the partial discharge detection system using an antenna with the region from 200 MHz to 300 MHz placed inside the VCB. However, if the partial discharge occurs outside the VCB, the detection system leads to misdetection as the partial discharge inside the VCB. In order to improve the performance of partial discharge detection, the outputs of antenna voltages inside and outside the VCB are investigated.
The “great flood” of 1926: environmental change and post‐disaster management in british malaya
Authors: Williamson Fiona 
Published: December 2016

Abstract
This paper is an historical case study of a major flood that occurred in British Malaya in 1926. It focuses on two key points. First, that the magnitude and subsequent impacts of the flood were exacerbated by contemporary industrial, agricultural, and hydraulic practices. Second, that this event pushed the British colonial government toward improving their land and river management strategies over the following decades. This article draws on recent research arguing the importance of an historical approach to disaster, as it enables greater insight into a disaster's causes and long‐term political, social, and environmental ramifications. Focussing on December 1926—a month of especially severe flooding likely linked to La Niña—this article will explore how those inundations became disastrous because of man‐made changes enacted on the local environment. It will consider the sequential effect of the inundations, from their immediate to medium‐term impact on the environment, to subsequent government‐led flood mitigation schemes. By viewing the mid‐1920s floods as a catalyst for change, with the benefit of hindsight, it is also possible to assess how far these changes were positive or negative.