bluuebunny/crossref_metadata_2025_split huggingface dataset:
THE INFLUENCE OF DIFFERENT VENTILATION PATTERNS ON TREATMENT OF PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY
Authors: Oliynyk O. V. , Pereviznyk B. O. , Shlifirchyk A. 
Published: February 2017

Background. Respiratory support is a vital method for temporary compensation of external breathing function in patients with severe traumatic brain injury. However, it is not always possible to deal with severe respiratory dysfunction even with the usage of up-to-date respiratory technologies. This work is aimed to find an answer how different pattern of mechanical ventilation influence on a treatment of patients with severe traumatic brain injury. Objective. The influence of respiratory support, as a main method for temporary compensation of external breathing function, on treatment result for patients with severe traumatic brain injury.Methods. Treatment results of 253 patients with severe traumatic brain injury of Ternopil University Hospital were evaluated due to the type of respiratory support used. The results were separately evaluated in alive and dead patients.Results. Mortality rate of patients depended on the type of mechanical ventilation that was used. The highest mortality (58.69 %) was in the group, when a patient was transferred to forced ventilation a volume control. The mortality rate was decreasing by 51.78% in case of adding PEEP. The strategy of using accessory lung ventilation patterns CPAP and BiPAP caused significant (in 1.48 times) decrease of mortality in this group of patients.Conclusion The survival of patients with severe traumatic brain injury, who were ventilated by the method of consistent combination of forced ventilation with pressure control (CРV) and 2 patterns of accessory lung ventilation: Constant Positive Airway Pressure (CPAP) and Biphasic positive airway pressure (BiPAP), is reliably higher than in the case of forced ventilation with volume control with Positive end-expiratory pressure.
Mayflies of the Caucasus Mountains. IV. New species of the genus Nigrobaetis Novikova &amp; Kluge, 1987 (Ephemeroptera, Baetidae) from Georgia
Authors: MARTYNOV ALEXANDER V. , GODUNKO ROMAN J. 
Published: February 2017

A new species of the genus Nigrobaetis Novikova & Kluge, 1987 is described based on larvae from the Caucasus Mountains. Nigrobaetis (Takobia) katerynae Martynov, sp. nov., is easily distinguishable from other Takobia species by the following combination of characters: the shapes of frontal suture, mandibles, labial palp, paraproctal prolongation, gills; the number of setal rows along the external margins of femora; the absence of gills on tergum I; and the colour pattern of body.
Emergent Constraints in Climate Projections: A Case Study of Changes in High-Latitude Temperature Variability
Authors: Borodina Aleksandra , Fischer Erich M. , Knutti Reto 
Published: February 2017

Abstract
Climate projections from phase 5 of the Coupled Model Intercomparison Project (CMIP5) ensemble show a decrease in interannual surface temperature variability over high latitudes with a large intermodel spread, in particular over the areas of sea ice retreat. Here relationships are found between the models’ present-day performance in sea ice–related metrics and future changes in temperature variability. These relations, so-called emergent constraints, can produce ensembles of models calibrated with present-day observations with a narrower spread across their members than across the full ensemble. The underlying assumption is that models in better agreement with observations or reanalyses in a carefully selected metric probably have a more realistic representation of local processes, and therefore are more reliable for projections. Thus, the reliability of this method depends on the availability of high-quality observations or reanalyses. This work represents a step toward formalization of the emergent constraints framework, as so far there is no consensus on how the constraints should be best implemented. The authors quantify the reduction in spread from emerging constraints for various metrics and their combinations, different emission scenarios, and seasons. Some of the general features of emerging constraints are discussed, and how to effectively aggregate information across metrics and seasons to achieve the largest reduction in model spread. It is demonstrated, based on the case of temperature variability, that a robust constraint can be obtained by combining relevant metrics across all seasons. Such a constraint results in a strongly reduced spread across model projections, which is consistent with a process understanding of variability changes due to sea ice retreat.
Observation of a Large Lee Wave in the Drake Passage
Authors: Cusack Jesse M. , Naveira Garabato Alberto C. , Smeed David A. , Girton James B. 
Published: February 2017

AbstractLee waves are thought to play a prominent role in Southern Ocean dynamics, facilitating a transfer of energy from the jets of the Antarctic Circumpolar Current to microscale, turbulent motions important in water mass transformations. Two EM-APEX profiling floats deployed in the Drake Passage during the Diapycnal and Isopycnal Mixing Experiment (DIMES) independently measured a 120 ± 20-m vertical amplitude lee wave over the Shackleton Fracture Zone. A model for steady EM-APEX motion is developed to calculate absolute vertical water velocity, augmenting the horizontal velocity measurements made by the floats. The wave exhibits fluctuations in all three velocity components of over 15 cm s−1 and an intrinsic frequency close to the local buoyancy frequency. The wave is observed to transport energy and horizontal momentum vertically at respective peak rates of 1.3 ± 0.2 W m−2 and 8 ± 1 N m−2. The rate of turbulent kinetic energy dissipation is estimated using both Thorpe scales and a method that isolates high-frequency vertical kinetic energy and is found to be enhanced within the wave to values of order 10−7 W kg−1. The observed vertical flux of energy is significantly larger than expected from idealized numerical simulations and also larger than observed depth-integrated dissipation rates. These results provide the first unambiguous observation of a lee wave in the Southern Ocean with simultaneous measurements of its energetics and dynamics.
Microstructures in striato-thalamo-orbitofrontal circuit in methamphetamine users
Authors: Li Yadi , Dong Haibo , Li Feng , Wang Gaoyan , Zhou Wenhua , Yu Rongbin , Zhang Lingjun 
Published: February 2017

Background Striato-thalamo-orbitofrontal (STO) circuit plays a key role in the development of drug addiction. Few studies have investigated its microstructural abnormalities in methamphetamine (MA) users. Purpose To evaluate the microstructural changes and relevant clinical relevance of the STO circuit in MA users using diffusion tensor imaging (DTI). Material and Methods Twenty-eight MA users and 28 age-matched normal volunteers were enrolled. 3T magnetic resonance imaging (MRI) was employed to obtain structural T1-weighted (T1W) imaging and diffusion-tensor imaging (DTI) data. Freesurfer software was used for automated segmentation of the bilateral nucleus accumbens (NAc), thalami, and orbitofrontal cortex (OFC). Four DTI measures maps, fractional anisotropy (FA), mean diffusivity (MD), axial diffusion (AD), and radial diffusion (RD) were generated and non-linearly co-registered to structural space. Comparisons of DTI measures of the STO circuit were carried out between MA and controls using repeated measures analysis of variance. Correlation analyses were performed between STO circuit DTI measures and clinical characteristics. Results The MA group had significant FA reduction in the bilateral NAc, OFC, and right thalamus ( P < 0.05). Lower left OFC FA and right NAc FA/AD were associated with longer duration of MA use. Lower right OFC FA was associated with younger age at first MA use. Higher FA and lower MD/RD in the thalamus, as well as higher left OFC RD, were associated with increased psychiatric symptoms. Conclusion The STO circuit has reduced microstructural integrity in MA users. Microstructural changes in the thalamus may compensate for dysfunction in functionally connected cortices, which needs further investigation.
The effect of ulnar variance on scapholunate and capitolunate angles
Authors: Tosun Ozgur , Çilengir Atilla Hikmet , Dirim Mete Berna , Uluc Muhsin Engin , Oyar Orhan , Tosun Aliye 
Published: February 2017

Background Ulnar variance (UV), which is measured using anteroposterior (AP) X-rays, is associated with the development of multiple wrist pathologies. The scapholunate angle (SLA) and capitolunate angle (CLA) are measured using lateral X-rays, and these can be used in the diagnosis of intercalated segmental instability. Purpose To determine the effect of UV on SLA and CLA. Material and Methods A total of 140 patients (73 women, 67 men; mean age, 37.8 ± 14.6 years; 95% confidence interval [CI], 35.4–40.3) were included in the study. Participants were excluded if they presented with fractures or malunions, any arthritic conditions, avascular necrosis, congenital deformities, or bone and soft tissue tumors. UV, SLA, and CLA were measured using AP and lateral wrist X-rays. Results Patients were grouped as positive, neutral, and negative UV. There was no statistically significant difference in mean ages, sex, and sides (left or right) between the UV groups ( P > 0.05). In addition, there was no statistically significant difference in the mean values of SLA and CLA between the UV groups ( P > 0.05). UV showed no statistically significant association with SLA and CLA (r = –0.064; P = 0.455, and r = 0.059; P = 0.485, respectively). However, there was a statistically significant association between SLA and CLA (r = –0.482; P < 0.001). Conclusion There is higher prevalence of neutral UV and no correlation between UV with respect to age and sex of patients in the local Turkish population. SLA and CLA are not affected by UV. There is a negative correlation between SLA and CLA.
Efficacy of bubaline fibrin glue on full-thickness pinch and punch skin grafting in a pig
Authors: Dejyong Krittee , Kaewamatawong Theerayuth , Brikshavana Pasakorn , Durongphongtorn Sumit 
Published: February 2017

Fibrin glue, which is formed from the action of thrombin (a serine protease) on fibrinogen, has been developed for use as an adhesive to increase the success of skin graft surgery. The objective of this study was to evaluate if bubaline fibrin glue would promote skin graft survival in pigs. The grafting was divided into two steps. First, granulation wound preparation was performed in a healthy swine by creating four full-skin depth wounds (3 × 12 cm2) at the dorsal part of the loin area on each side. Second, pinch and punch skin grafting, where eight skin discs (0.6 cm diameter) were regularly placed (0.6 cm distance apart) in the granulation tissue bed of each wound, was performed 5 days later. The bubaline fibrin glue was added prior to application of the 16 skin graft discs in two of the wounds, while no glue was added to the other 16 skin graft discs in the other two wounds. The number of surviving graft pieces and histological examination was evaluated after 3, 7, and 14 days post-operation and compared by pairing between the control and the bubaline fibrin glue groups. The number of grafts that remained at 3 and 7 days post-operation and the number of new microvessels at 3 days post-operation were significantly higher ( p < 0.05) in the bubaline fibrin glue group than in the control group. However, there was no significant difference in the number of fibroblasts, the intensity of scarring and the intensity of inflammation between the two groups, except for the significantly lower intensity of inflammation at 7 days post-operation in the bubaline fibrin glue group. In conclusion, bubaline fibrin glue has the advantage of decreasing the skin graft loss by approximately 31.3–37.5% compared with the control group and also promotes angiogenesis.
Disease characterization of systemic lupus erythematosus (SLE) patients in Quebec
Authors: Ng R , Bernatsky S , Rahme E 
Published: February 2017

Objective Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by an array of organ manifestations that can appear during flares and disappear during remissions. The objectives of this study were: (i) to examine SLE manifestation groups longitudinally in an SLE cohort; and (ii) to assess the association between early antimalarial treatment and renal manifestations. Methods Seven SLE manifestation groups—cutaneous, hematologic, lung, musculoskeletal, neuropsychiatric, serositis, renal—were tracked using Kaplan-Meier survival curves in an incident SLE cohort from Quebec health administrative data ( n = 2010). A subgroup with provincial drug insurance coverage was followed over time to examine the association between early antimalarial treatment (within three months after SLE diagnosis) and renal manifestations using a Cox proportional hazards survival model. Results Cutaneous manifestations was the most common manifestation at SLE diagnosis (30.0%, 95% CI: 27.7–32.2%). About two-thirds (66.2%, 95% CI: 63.4–68.9%) of patients had evidence of at least one SLE manifestation at diagnosis, which increased to 87.2% (95% CI: 84.2–90.3%) by the end of follow-up. After adjusting for age, sex, early concomitant systemic steroid therapy, Charlson comorbidity index, primary care visits in the year prior and other SLE manifestations at baseline, no statistically significant association was established between antimalarial therapy and renal manifestations. Conclusion This study provides insight regarding organ manifestations within a population-based sample. Most patients identified with SLE had other diagnostic evidence that supports an underlying diagnosis of SLE. No protective effects for antimalarial agents against renal manifestations could be established in this population-based cohort.
The relationship between white matter fiber damage and gray matter perfusion in large-scale functionally defined networks in multiple sclerosis
Authors: Ma Ashley Y , Vitorino Rita C , Hojjat Seyed-Parsa , Mulholland Alannah D , Zhang Liying , Lee Liesly , Carroll Timothy J , Cantrell Charles G , Figley Chase R , Aviv Richard I 
Published: February 2017

Background: Recent studies utilizing perfusion as a surrogate of cortical integrity show promise for overall cognition, but the association between white matter (WM) damage and gray matter (GM) integrity in specific functional networks is not previously studied. Objective: To investigate the relationship between WM fiber integrity and GM node perfusion within six functional networks of relapsing-remitting multiple sclerosis (RRMS) and secondary progressive multiple sclerosis (SPMS) patients. Methods: Magnetic resonance imaging (MRI) and neurocognitive testing were performed on 19 healthy controls (HC), 39 RRMS, and 45 SPMS patients. WM damage extent and severity were quantified with T2-hyper/T1-hypointense (T2h/T1h) lesion volume and degree of perfusion reduction in lesional and normal-appearing white matter (NAWM), respectively. A two-step linear regression corrected for confounders was employed. Results: Cognitive impairment was present in 20/39 (51%) RRMS and 25/45 (53%) SPMS patients. GM node perfusion was associated with WM fiber damage severity (WM hypoperfusion) within each network—including both NAWM ( R2 = 0.67–0.89, p < 0.0001) and T2h ( R2 = 0.39–0.62, p < 0.0001) WM regions—but was not significantly associated ( p > 0.01) with WM fiber damage extent (i.e. T2h/T1h lesion volumes). Conclusion: Overall, GM node perfusion was associated with severity rather than extent of WM network damage, supporting a primary etiology of GM hypoperfusion.
Ginsenoside Rg1 improves fertility and reduces ovarian pathological damages in premature ovarian failure model of mice
Authors: He Lianli , Ling Li , Wei Tianqin , Wang Yaping , Xiong Zhengai 
Published: February 2017

This study aims to investigate the effect as well as mechanism of ginsenoside Rg1 (Rg1) on premature ovarian failure (POF) induced by d-galactose (d-gal) in mice. C57BL/6 female mice were divided into four groups randomly, which were the saline group, the d-gal group, the d-gal + Rg1 group, and the Rg1 group. Body weight was recorded. Overall ovarian function including estrous cycles, sex hormone secretion, ovarian follicle development, and ovarian morphology was analyzed by H&E staining and ELISA. Effect of Rg1 on aging was determined by analyzing the activities of oxidation-associated biomarkers, pro-inflammatory cytokine secretion, expression of senescence-associated proteins, and fertility. Compared with the d-gal group, in Rg1 + d-gal group, body weight was increased significantly, estrous cycle block was released, and fertility and the morphology of ovaries were restored. And, Rg1 treatment after d-gal administration significantly reduced senescence-associated protein expression, increased the activity of total superoxide dismutase and glutathione peroxidase from bovine erythrocyte, and induced higher follicle stimulating hormone receptor protein expression. Additionally, the expression levels of malondialdehyde, interleukin-1β, tumor necrosis factor-α, and interleukin-6 were significantly decreased. Together, Rg1 improves mouse fertility and reduces ovarian pathological damage in d-gal-induced POF model possibly through enhancing anti-inflammatory and antioxidant capacities and reducing expression of senescence signal pathway proteins. Impact statement Ginsenoside Rg1 (Rg1) is a kind of natural estrogen and it has antioxidation and antiaging effects. However, whether Rg1 has effects on premature ovarian failure (POF) is still not clear. In this study, aging model induced by d-galactose was used to mimic POF. The effect and possible mechanism of Rg1 on ovary aging was investigated. We found that Rg1 treatment up-regulated the expression of follicle stimulating hormone receptor and down-regulated senescence-associated protein expression in granule cells of POF mice. Particularly, Rg1 improved fertility ability and reduced ovarian pathological damages by its antioxidative and anti-inflammation capacity. Thus, Rg1 enhances the antiaging ability of ovary and fertility ability of POF mice through enhancing the anti-inflammatory and antioxidant capacities of ovary.
A contemporary evaluation of carotid endarterectomy outcomes in patients with chronic kidney disease in the United States
Authors: Patel Amit R , Dombrovskiy Viktor Y , Vogel Todd R 
Published: February 2017

Objectives Chronic kidney disease (CKD) has been identified as a significant risk factor for poor post-surgical outcomes. This study was designed to provide a contemporary analysis of carotid endarterectomy (CEA) outcomes in patients with CKD, end-stage renal disease (ESRD), and normal renal function (NF). Methods The Nationwide Inpatient Sample data 2006–2012 was queried to select patients aging 40 years old and above who underwent CEA during two days after admission and had a diagnosis of ESRD on long-term hemodialysis, patients with non-dialysis-dependent CKD, or NF. Patients with acute renal failure were excluded. We subsequently compared procedure outcomes and hospital resource utilization in these patients. Results Totally 573,723 CEA procedures were estimated: 4801 (ESRD)‚ 32,988 (CKD)‚ and 535,934 (NF). Mean age was 71.0 years, 57.7% were males, and 73.7% were white. Overall hospital mortality was 0.20%: 0.69% (ESRD), 0.35% (CKD), and 0.19% (NF), p < 0.0005 between groups. The overall stroke rate was 1.6%: 1.8% (ESRD), 2.0% (CKD), and 1.6% (NF). Comparing NF to CKD there was a significant difference: p < 0.0001. For CKD patients, compared to NF patients, there was an increased risk in cardiac complications (odds ratio = 1.2; 95% CI 1.15–1.32), respiratory complications (odds ratio = 1.2; 95% CI 1.15–1.32), and stroke (odds ratio = 1.1; 95% CI 1.04–1.23). For ESRD patients compared to NF patients there was an increased risk in respiratory complications (odds ratio = 1.3; 95% CI 1.08–1.47) and sepsis (odds ratio = 4.4; 95% CI 3.23–5.94). Mean length of stay and cost were: 2.8 d and $13,903 (ESRD), 2.2 d and $12,057 (CKD), and 1.8 d and $10,130 (NF), all p < 0.0001. Conclusions Patients with ESRD undergoing CEA had an increased risk of respiratory and septic complications, but not a higher risk of stroke compared to patients with normal renal function. The greatest risks of postoperative stroke, respiratory, and cardiac complications were found in patients with CKD. A diagnosis of ESRD and CKD were both found to significantly increase hospital mortality, length of stay and cost. Where clinicians typically consider ESRD patients the highest risk for CEA, further consideration should be given to patients with CKD not yet on dialysis as they had the higher risk of cardiac complications and stroke compared to the others evaluated.
Evaluation of radiographic fracture position 1 year after variable angle locking volar distal radius plating: a prospective multicentre case series
Authors: Teunis T. , Jupiter J. , Schaser K. D. , Fronhöfer G. , Babst R. , Langer M. , Platz A. , Schierz A. , Joeris A. , Rikli D. 
Published: February 2017

Treatment with a variable angle locking plate can, in theory, maintain near anatomic reduction of intra-articular distal radius fractures, but it is unknown to what extent reduction is maintained as measured by computed tomography. We assessed changes in radiographic fracture position 1 year post-operatively. We included 73 patients of whom 66 patients (90%) had radiographs available for review at 1 year post-operatively. We found a small (less than 2 mm or 2°) but statistically significant change in several measures. Accounting for inter-observer variability, this is probably within measurement error. We found no difference in change in fracture position or range of motion, grip strength or patient-reported outcome between the use of one or two distal rows of screws. Our results show that minimal changes in reduction can be expected after volar plate fixation in most patients. We recommend using only one screw row routinely, limiting costs, surgical time and the risk of misplacement of screws. Level of evidence: IV
T-cell assays confirm immunogenicity of tungsten-induced erythropoietin aggregates associated with pure red cell aplasia
Authors: Rubic-Schneider Tina , Kuwana Masataka , Christen Brigitte , Aßenmacher Manuela , Hainzl Otmar , Zimmermann Frank , Fischer Robert , Koppenburg Vera , Chibout Salah-Dine , Wright Timothy M. , Seidl Andreas , Kammüller Michael 
Published: February 2017

Key Points
Tungsten-induced rhEPO aggregates in clinical lots are associated with rhEPO-neutralizing antibodies and PRCA. T-cell responses differentiate nonaggregated from aggregated rhEPO, confirming immunogenicity of tungsten-induced rhEPO aggregates.