bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non‐periodic pulse signal detection based on variable scale coupled Duffing oscillators
Authors: Luo Wen‐mao , Zhang Ye‐rong 
Published: January 2018

Detection of the pulse signal at low signal‐to‐noise ratio (SNR) is difficult but meaningful. Some documents have already used coupled Duffing oscillators to detect non‐periodic pulse signal, but those oscillators have a few defects. This Letter presents a type of strong coupled Duffing oscillators system, and by using the generalised time scale transformation, the system can detect signal with any sampling frequency. The system is coupled by damping force and restoring force of the oscillators and has characteristics of high synchronisation speed and high coupling degree. The simulation results show that the system can detect large amplitude signal, large time‐width pulse, and plus–minus signal, and the detection SNR is lower than −27 dB.
A 2.4/3.5/5.2/5.8‐GHz quad‐band BPF using SLRs and triangular loop resonators
Authors: Wang Jinchen , He Songbai , Gan Decheng 
Published: January 2018

A modified triangular loop resonator with an open‐circuited stepped‐impedance stub, which can generate two closely spaced passbands at 5.2 and 5.8 GHz, is analysed. For verification, the triangular loop resonators along with stub‐loaded resonators (SLRs) are then employed to design a compact 2.4/3.5/5.2/5.8‐GHz quad‐band bandpass filter (BPF) for wireless local area networks as well as worldwide interoperability for microwave access applications. Each of the four centre frequencies in the proposed quad‐band BPF is able to be controlled due to the design freedom.
High‐efficient inverting buck‐boost converter with fully digital‐controlled switch width modulation for microdisplays
Authors: Shin S.‐H. , Hong S.‐K. , Kwon O.‐K. 
Published: January 2018

This letter proposes a highly efficient inverting buck‐boost converter at light‐load for microdisplay applications. The proposed buck‐boost converter, which operates in discontinuous conduction mode, achieves high efficiency by modulating the switch width according to the sensed on‐duty of the main power switch using the full‐digital method. It generates an output voltage of −4 V using an input voltage of 1.8 V for a maximum load current (ILOAD) of 20 mA. The proposed converter was fabricated in a 0.18 μm bipolar CMOS DMOS (BCDMOS) process and measured to verify its performance. The measurement results showed that the proposed buck‐boost converter achieved a maximum efficiency of 89.3% at ILOAD of 20 mA and a high efficiency of up to 81.9% at light‐load, where ILOAD is <5 mA.
Calcium deficiency in hydroxyapatite and its drug delivery applications
Authors: Koppala Sivasankar , Swamiappan Sasikumar , Gangarajula Yuvaraj , Xu Lei , Sadasivuni Kishor Kumar , Ponnamma Deepalekshmi , Rajagopalan Vijayaraghavan 
Published: January 2018

In this work, calcium deficient hydroxyapatites (HAPs) [Ca10−x (PO4)6 (OH)2] [where x = 0 − 0.3] were synthesised by precipitation method and calcined samples were characterised by Fourier transformation infrared spectroscopy, powder X‐ray diffraction, scanning electron microscopy and energy‐dispersive X‐ray spectroscopy techniques to check phase purity, calcium deficiency, particle size and shape. The results indicate that the structure of the HAP can tolerate a calcium deficiency up to 0.2. The calcium deficient HAP (x = 0.1) powder was found to be highly porous with a particle size below 200 nm. This powder was used as a drug delivery carrier for the drug, ciprofloxacin and sustained release of the drug in the phosphate buffer solution was investigated.
Preparation of silver/chemically reduced graphene composite for flexible printed circuits
Authors: Feng Bin , Ma Junjie , Gu Xiaolong , Zhao Xinbing , Zhang Yu 
Published: January 2018

Silver (Ag)/chemically reduced graphene (Ag/CGN) composite succeeded prepared using a simple chemical reduction method. X‐ray diffraction, Raman spectra, Fourier transform infrared spectroscopy and X‐ray photoelectron spectroscopy results revealed the formation of Ag and the reduction of graphite oxide to graphene during the synthesis process. Scanning electron microscopy observation showed that Ag particles were wrapped by graphene. The resistance of Ag/CGN circuits changed <10% when bended at a radius of 10 mm after 500 cycles and <15% when folded after 50 cycles, indicating the printed Ag/CGN fine circuits possess good electrical conductivity, flexibility and electrical stability under mechanical deformations. Furthermore, the Ag/CGN circuits exhibited high thermal stability, indicating its potential application for fabricating high performance flexible printed circuits.
Constraints from thermal Sunyaev-Zel’dovich cluster counts and power spectrum combined with CMB
Authors: Salvati Laura , Douspis Marian , Aghanim Nabila 
Published: January 2018

The thermal Sunyaev-Zel’dovich (tSZ) effect is one of the recent probes of cosmology and large-scale structures. We update constraints on cosmological parameters from galaxy clusters observed by thePlancksatellite in a first attempt to combine cluster number counts and the power spectrum of hot gas; we used a new value of the optical depth and, at the same time, sampling on cosmological and scaling-relation parameters. We find that in the ΛCDM model, the addition of a tSZ power spectrum provides small improvements with respect to number counts alone, leading to the 68% c.l. constraints Ωm= 0.32 ± 0.02,σ8= 0.76 ± 0.03, andσ8(Ωm/0.3)1/3= 0.78 ± 0.03 and lowering the discrepancy with results for cosmic microwave background (CMB) primary anisotropies (updated with the new value ofτ) to ≃1.8σonσ8. We analysed extensions to the standard model, considering the effect of massive neutrinos and varying the equation of state parameter for dark energy. In the first case, we find that the addition of the tSZ power spectrum helps in improving cosmological constraints with respect to number count alone results, leading to the 95% upper limit ∑mν< 1.88 eV. For the varying dark energy equation of state scenario, we find no important improvements when adding tSZ power spectrum, but still the combination of tSZ probes is able to provide constraints, producingw= −1.0 ± 0.2. In all cosmological scenarios, the mass bias to reconcile CMB and tSZ probes remains low at (1 −b) ≲ 0.67 as compared to estimates from weak lensing and X-ray mass estimate comparisons or numerical simulations.
RAPTOR
Authors: Bronzwaer T. , Davelaar J. , Younsi Z. , Mościbrodzka M. , Falcke H. , Kramer M. , Rezzolla L. 
Published: January 2018

Context. Observational efforts to image the immediate environment of a black hole at the scale of the event horizon benefit from the development of efficient imaging codes that are capable of producing synthetic data, which may be compared with observational data.
Aims. We aim to present RAPTOR, a new public code that produces accurate images, animations, and spectra of relativistic plasmas in strong gravity by numerically integrating the equations of motion of light rays and performing time-dependent radiative transfer calculations along the rays. The code is compatible with any analytical or numerical spacetime. It is hardware-agnostic and may be compiled and run both on GPUs and CPUs.
Methods. We describe the algorithms used in RAPTOR and test the code’s performance. We have performed a detailed comparison of RAPTOR output with that of other radiative-transfer codes and demonstrate convergence of the results. We then applied RAPTOR to study accretion models of supermassive black holes, performing time-dependent radiative transfer through general relativistic magneto-hydrodynamical (GRMHD) simulations and investigating the expected observational differences between the so-called fast-light and slow-light paradigms.
Results. Using RAPTOR to produce synthetic images and light curves of a GRMHD model of an accreting black hole, we find that the relative difference between fast-light and slow-light light curves is less than 5%. Using two distinct radiative-transfer codes to process the same data, we find integrated flux densities with a relative difference less than 0.01%.
Conclusions. For two-dimensional GRMHD models, such as those examined in this paper, the fast-light approximation suffices as long as errors of a few percent are acceptable. The convergence of the results of two different codes demonstrates that they are, at a minimum, consistent.
Conception of a New Recoil Proton Telescope for Real-Time Neutron Spectrometry in Proton-Therapy
Authors: Combe Rodolphe , Arbor Nicolas , el Bitar Ziad , Higueret Stéphane , Husson Daniel 
Published: January 2018

Neutrons are the main type of secondary particles emitted in proton-therapy. Because of the risk of secondary cancer and other late occurring effects, the neutron dose should be included in the out-of-field dose calculations. A neutron spectrometer has to be used to take into account the energy dependence of the neutron radiological weighting factor. Due to its high dependence on various parameters of the irradiation (beam, accelerator, patient), the neutron spectrum should be measured independently for each treatment.
The current reference method for the measurement of the neutron energy, the Bonner Sphere System, consists of several homogeneous polyethylene spheres with increasing diameters equipped with a proportional counter. It provides a highresolution reconstruction of the neutron spectrum but requires a time-consuming work of signal deconvolution. New neutron spectrometers are being developed, but the main experimental limitation remains the high neutron flux in proton therapy treatment rooms. A new model of a real-time neutron spectrometer, based on a Recoil Proton Telescope technology, has been developed at the IPHC. It enables a real-time high-rate reconstruction of the neutron spectrum from the measurement of the recoil proton trajectory and energy. A new fast-readout microelectronic integrated sensor, called FastPixN, has been developed for this specific purpose.A first prototype, able to detect neutrons between 5 and 20 MeV, has already been validated for metrology with the AMANDE facility at Cadarache. The geometry of the new Recoil Proton Telescope has been optimized via extensive Geant4 Monte Carlo simulations. Uncertainty sources have been carefully studied in order to improve simultaneously efficiency and energy resolution, and solutions have been found to suppress the various expected backgrounds. We are currently upgrading the prototype for secondary neutron detection in proton therapy applications.
Measuring Electronic Health Record Use in Primary Care: A Scoping Review
Authors: Huang Michael , Gibson Candace , Terry Amanda 
Published: January 2018

Background Simple measures of electronic health record (EHR) adoption may be inadequate to evaluate EHR use; and positive outcomes associated with EHRs may be better gauged when varying degrees of EHR use are taken into account. In this article, we aim to assess the current state of the literature regarding measuring EHR use.
Objective This article conducts a scoping review of the literature to identify and classify measures of primary care EHR use with a focus on the Canadian context.
Methods We conducted a scoping review. Multiple citation databases were searched, as well as gray literature from relevant Web sites. Resulting abstracts were screened for inclusion. Included full texts were reviewed by two authors. Data from the articles were extracted; we synthesized the findings. Subsequently, we reviewed these results with seven EHR stakeholders in Canada.
Results Thirty-seven articles were included. Eighteen measured EHR function use individually, while 19 incorporated an overall level of use. Eight frameworks for characterizing overall EHR use were identified.
Conclusion There is a need to create standardized frameworks for assessing EHR use.
Direct Oral Anticoagulants in End-Stage Renal Disease
Authors: Tagalakis Vicky , Klil-Drori Adi 
Published: January 2018

AbstractPatients with end-stage renal disease (ESRD) were excluded from pivotal clinical trials with oral anticoagulants. While such patients are at an increased risk of venous and arterial thromboembolism, their risk of bleeding is also elevated. It is thus of little surprise that stroke prevention with vitamin K antagonists (VKAs) in ESRD patients with atrial fibrillation is controversial, with observational evidence ranging from beneficial to harmful. This uncertainty extends to the less studied use of VKAs for venous thromboembolism in ESRD. The direct oral anticoagulants (DOACs) apixaban and rivaroxaban have now permissive labeling in the United States for atrial fibrillation in patients with ESRD; this expanded labeling has not yet occurred either in Europe or for venous thromboembolism. This review summarizes the current evidence for the pharmacology of DOACs in ESRD as well as their utilization and safety in patients with ESRD and atrial fibrillation.
Kompetenzbasierte Ausbildung im „geschützten Umfeld“: vom Schonraum zum Realraum
Authors: Quandt Christina , Friedrich Lars 
Published: January 2018

Zusammenfassung„Lernen im geschützten Umfeld“ ist ein häufig gebrauchter, aber unklarer Begriff im Rahmen der anästhesiologischen postgradualen Weiterbildung. Dieser Artikel beleuchtet seine Bedeutung in der Anästhesiologie – einschließlich Lehr- und Lernstrategien, wie kompetenzorientierte und simulationsbasierte Ausbildung. Ein Versuch der Klassifikation von Simulatoren und Unterrichtsmethoden sowie deren Probleme bei der Umsetzung runden den Beitrag ab.
Cloning of a novel lectin from Artocarpus lingnanensis that induces apoptosis in human B-lymphoma cells
Authors: Luo Yu , Liu Xiaoqin , Lin Faquan , Liao Liejun , Deng Yong , Zeng Linjie , Zeng Qiyan 
Published: January 2018

Abstract
We isolated a novel lectin (Artocarpus nitidus subsp. lingnanensis lectin, ALL) from Artocarpus nitidus subsp. lingnanensis and showed its mitogenic activities. In this study, we determined the amino acid sequence of ALL by cDNA sequencing. ALL cDNA (933 bp) contains a 657-bp open reading frame (ORF), which encodes a protein with 218 amino acids. ALL shares high sequence similarities with Jacalin and Morniga G and belongs to jacalin-related lectin family. We also examined the antitumor activity of ALL using Raji, a human B-lymphoma cell line. ALL exhibits a strong binding affinity to cell membrane, which can be effectively inhibited by N-acetyl-D-galactosamine (GalNAc). ALL inhibits Raji cell proliferation in a time- and dose-dependent manner through apoptosis, evidenced by morphological changes, phosphatidylserine externalization, poly ADP-ribose polymerase (PARP) cleavage, Bcl-2 down-regulation, and caspase-3 activation. We further showed that the activation of p38 mitogen-activated protein kinase (MAPK) signaling pathways is required for the pro-apoptotic activity of ALL.
Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors
Authors: Mannakee Brian K , Balaji Uthra , Witkiewicz Agnieszka K , Gutenkunst Ryan N , Knudsen Erik S 
Published: January 2018

Abstract

Motivation
Tumor genome sequencing offers great promise for guiding research and therapy, but spurious variant calls can arise from multiple sources. Mouse contamination can generate many spurious calls when sequencing patient-derived xenografts. Paralogous genome sequences can also generate spurious calls when sequencing any tumor. We developed a BLAST-based algorithm, Mouse And Paralog EXterminator (MAPEX), to identify and filter out spurious calls from both these sources.

Results
When calling variants from xenografts, MAPEX has similar sensitivity and specificity to more complex algorithms. When applied to any tumor, MAPEX also automatically flags calls that potentially arise from paralogous sequences. Our implementation, mapexr, runs quickly and easily on a desktop computer. MAPEX is thus a useful addition to almost any pipeline for calling genetic variants in tumors.

Availability and implementation
The mapexr package for R is available at https://github.com/bmannakee/mapexr under the MIT license.

Supplementary information
Supplementary data are available at Bioinformatics online.
Dual Antiplatelet Therapy Combining Aspirin and Ticagrelor for Intracranial Stenting Procedures: A Retrospective Single Center Study of 154 Consecutive Patients With Unruptured Aneurysms
Authors: Narata Ana Paula , Amelot Aymeric , Bibi Richard , Herbreteau Denis , Angoulvant Denis , Gruel Yves , Janot Kevin 
Published: January 2018

Abstract

BACKGROUND
Dual antiplatelet therapy (DAPT) associating aspirin + clopidogrel is commonly utilized in neurovascular interventions despite unpredictable clopidogrel efficacy with 4% to 50% of patients considered nonresponders. Ticagrelor is an antiplatelet agent with low resistance rates but unknown efficacy and safety in neurovascular patients.

OBJECTIVE
To evaluate frequency of ischemic and hemorrhagic events in patients treated with aspirin and ticagrelor when associated with perioperative heparin bolus for unruptured aneurysms treated with intracranial stents.

METHODS
One hundred fifty-four consecutive patients with unruptured intracranial aneurysms treated by stent procedures (113 = flow diverter stent [FDS], 41 = stent-assisted coiling) were retrospectively analyzed. All patients received aspirin and ticagrelor without platelet function testing. Patients were separated in 2 groups following perioperative heparin dose: group I = 70 U/kg; group II = 50 U/kg. FDS versus stent-assisted coiling procedures were also separately analyzed.

RESULTS
Nine patients (5.8%) presented symptomatic neurological complications poststenting (3 ischemic, 6 hemorrhagic): 8 patients received 70 U/kg of heparin (11.1%) and 1 patient received 50 U/kg (1.2%; P < .009). Four patients died (2.6%) during the 3-mo follow-up period—all deaths were correlated to intracranial hemorrhage: 3 at group I and 1 at group II (P < .251). No difference in complications or death was observed considering separately FDS and stent-assisted coiling procedures.

CONCLUSION
This study did not find more neurological complications than in previous neurointerventional reports using DAPT with aspirin + ticagrelor or aspirin + clopidogrel. Overall number of neurological complications was lower when a lower dose of heparin was administered. Neurovascular studies comparing clopidogrel to ticagrelor and different doses of heparin are necessary to demonstrate which association is more efficient with lower complication rates.
Immunogenicity of high-dose influenza vaccination in patients with primary central nervous system malignancy
Authors: Strowd Roy E , Russell Gregory , Hsu Fang-Chi , Carter Annette F , Chan Michael , Tatter Stephen B , Laxton Adrian W , Alexander-Miller Martha A , High Kevin , Lesser Glenn J 
Published: January 2018

Abstract

Background
For cancer patients, rates of influenza-associated hospitalization and death are 4 times greater than that of the general population. Previously, we reported reduced immunogenicity to the standard-dose influenza vaccine in patients with central nervous system malignancy. In other poorly responding populations (eg, elderly patients), high-dose vaccination has improved efficacy and immunogenicity.

Methods
A prospective cohort study was designed to evaluate the immunogenicity of the Fluzone® high-dose influenza vaccine in brain tumor patients. Data on diagnosis, active oncologic treatment, and immunologic status (eg, CD4 count, CD8 count, CD4:CD8 ratio) were collected. All patients received the high-dose vaccine (180 µg). Hemagglutination inhibition titers were measured at baseline, day 28, and 3 months following vaccination to determine seroconversion (≥4-fold rise) and seroprotection (titer ≥1:40), which were compared to our prior results.

Results
Twenty-seven patients enrolled. Diagnoses included high-grade glioma (85%), CNS lymphoma (11%), and meningioma (4%). Treatment at enrollment included glucocorticoids (n = 8, 30%), radiation (n = 2, 7%), and chemotherapy (n = 9, 33%). Posttreatment lymphopenia (PTL, CD4 ≤ 200) was observed in 4 patients (15%). High-dose vaccination was well tolerated with no grade III-IV toxicity. Overall, seroconversion rates for the A/H1N1, A/H3N2, and B vaccine strains were significantly higher than in our prior study: 65% vs 37%, 69% vs 23%, and 50% vs 23%, respectively (all P < .04). Seroconversion was universally poor in patients with PTL. While seroprotection at 3 months declined in our prior study, no drop was observed following high-dose vaccination in this cohort.

Conclusions
The immunologic response to HD influenza vaccination was higher in this cohort than standard-dose influenza vaccination in our prior report. These findings mirror those in elderly patients where high-dose vaccination is the standard of care and raise the possibility of an immunosenescence phenotype.
An Updated Review of Iclaprim: A Potent and Rapidly Bactericidal Antibiotic for the Treatment of Skin and Skin Structure Infections and Nosocomial Pneumonia Caused by Gram-Positive Including Multidrug-Resistant Bacteria
Authors: Huang David B , Strader Catherine D , MacDonald James S , VanArendonk Mark , Peck Richard , Holland Thomas 
Published: January 2018

Abstract
New antibiotics are needed because of the increased morbidity and mortality associated with multidrug-resistant bacteria. Iclaprim, a bacterial dihydrofolate reductase inhibitor, not currently approved, is being studied for the treatment of skin infections and nosocomial pneumonia caused by Gram-positve bacteria, including multidrug-resistant bacteria. Iclaprim showed noninferiority at –10% to linezolid in 1 of 2 phase 3 studies for the treatment of complicated skin and skin structure infections with a weight-based dose (0.8 mg/kg) but did not show noninferiority at –10% to linezolid in a second phase 3 study. More recently, iclaprim has shown noninferiority at –10% to vancomycin in 2 phase 3 studies for the treatment of acute bacterial skin and skin structure infections with an optimized fixed dose (80 mg). A phase 3 study for the treatment of hospital-acquired bacterial and ventilator-associated bacterial pneumonia is upcoming. If, as anticipated, iclaprim becomes available for the treatment of skin and skin structure infections, it will serve as an alternative to current antibiotics for treatment of severe infections. This article will provide an update to the chemistry, preclinical, pharmacology, microbiology, clinical and regulatory status of iclaprim.
The effects of physical activity on survival in patients with colorectal cancer
Authors: DeTroye Alisha , Christner Margaret , Eganhouse Danielle , Manning Brittany , Sunkin Emily , Gregory Tanya 
Published: January 2018

ABSTRACT
Mortality from colorectal cancer has been declining over the past 20 years due to improvements in screening and treatment. Physical activity improves patient quality of life, slows functional decline, and reduces all-cause mortality. Although some patients may have difficulty participating in physical activity, clinicians should always try to incorporate exercise into a management plan for patients who have survived colorectal cancer.