bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of Shale Gas Reservoir in Barakar and Barren Measures Formations of North and South Karanpura Coalfields, Jharkhand
Authors: Mendhe V. A. , Kamble Alka D. , Bannerjee Mollika , Mishra Subhashree , Mukherjee Sabita , Mishra Parashar 
Published: September 2016

Abstract:
India recognizes the strategic importance for developing shale gas resources like other countries in the world. Shale gas reservoirs are known to be difficult for extracting gas in comparison to conventional reservoirs. Recently, due to high prices of gas, rising demand and enhancement in recovery technologies has attracted the Indian energy industries to explore the shale gas resource. Coal and lignite are the prime source of energy in India and these resources are well explored, while shale is ignored, despite it being associated with coal and lignite bearing formations. The paper presents reservoir characteristics of shale horizons in Barren Measures and Barakar formations of north and south Karanpura coalfields. Shale core samples were collected from exploratory boreholes in air tight canisters. In-situ gas content and adsorption capacities ascertained to be 0.51-1.69 m3/t and 3.90-5.82 m3/trespectively. Desorbed gas derived from canisters contains CH4, C2H6, C3H8, CO2, N2 and O2 and varies from 76.19-82.63, 0.38-0.76, 0.10-0.50, 8.65-12.34, 9.89-19.34 and 0.56-2.24 vol. % respectively. The permeability and porosity determined under reservoir simulated confining pressure is varying from 0.41-0.75 mD and 0.89-2.28 % respectively. The plots of Rock Eval S2vs TOC and HI against Calc. VRo% indicates that all shale samples belong to Type III kerogen, which is prone to generate gas. It is evaluated that in-situ gas content, sorption capacity, saturation level and low permeability of shale beds are critical parameters for development of shale gas resource in the studied area.
Hydrological Characterization of Budge Budge and Dum Dum Areas of South and North 24 Parganas Districts, West Bengal Using Geoelectric and Geochemical Methods
Authors: Majumdar R. K. , Kar S. , Panda A. , Samanta S. K. 
Published: September 2016

Abstract:
Integrated geoelectric, geological and geochemical investigations are carried out in Budge Budge and Dum Dum areas of south and north 24 Parganas district for ascertaining the prevailing hydrological condition and aquifer characteristic with chemical qualities of groundwater for drinking and irrigation purposes. The proposed areas are constituted of alluvium and marine sediments of Quaternary age being a part of Gangetic delta. Vertical electrical soundings (VES) of Budge Budge have delineated four to six layers consisting of top soils, the brackish water zone, clay layer, first fresh water zone, another clay layer and the bottom-most(sixth layer) second fresh water bearing zone. The first fresh water zone is located at a depth of 128 m with thickness of 43 m having resistivity range of 32 ohm.m to 37 ohm.m for VES locations BB2 and BB3. The resistivity of the deeper second fresh water bearing zone is varying from 47 ohm.m to 51 ohm.m. The interpreted VES results significantly correspond with the borehole litholog of Budge Budge area. Similar VES results are also obtained for Dum Dum area showing promising potential aquifer zone especially for VES locations DD3 and DD4. A litho-resistivity relation is also determined for the area. Total TDS content of Budge Budge ground water samples are ranging from 720 mg/l to 4400 mg/l and same is ranging from 1012 mg/l to 1930mg/l for Dum Dum ground water samples. According to IS standard, the value of major cations and anions are near to the permissible limit for Dum Dum but same is not observed in Budge Budge for drinking and irrigation purpose excepting location G7. According to Piper trilinear diagram, the ground water in Budge Budge area is sulphate rich type and in Dum Dum it is fresh in nature. Chemically, the groundwater samples from Dum Dum and Budge Budge is classified as (Ca+Mg+Cl+SO4) facies. The geochemical parameters like total hardness (TH), sodium adsorption ratio (SAR), soluble sodium percentage (SSP), Kelly’s ratio (KR), magnesium ratio (MR), residual sodium carbonate (RSC), corrosivity ratio (CR), Gibb’s ratio-I&II (GR-I & GR-II), chloro alkaline indices (CAI-I & CAI-II), permeability index (PI), sea water contamination (SWC) are also determined for better understanding of the quality of groundwater in the above areas.
Mineralogical Composition and Ash Geochemistry of Raw and Beneficiated High Sulfur Coals
Authors: Saikia Binoy K. , Mahanta Banashree , Gupta Upendra N. , Sahu Om P. , Saikia Prasenjit , Baruah Bimala P. 
Published: September 2016

Abstract:
Coal is one of the most available energy sources on earth. The mineralogical and geo-chemical aspects of coals are of prime importance for their utilization. The mineralogical composition, ash chemistry, and ash fusion temperature (AFT) ranges of raw and beneficiated coals are investigated in this paper. Further, the mineral matter transformation during the beneficiation processes viz. by oxidative desulfurization; alkali extraction and ultrasonication along with the relationship of the ash fusion temperature (AFT) ranges with the ash components in the coal are discussed. The major oxides present in the coal and beneficiated coal ashes include Fe2O3, Al2O3, SiO2, CaO, and MgO, which significantly affect the ash fusion temperature ranges. Initial deformation temperature (IDT) changes with the ash components and, increases with the increase in the Fe2O3 content in coal ash. With increasing concentrations of both Al2O3 and SiO2, the initial deformation temperature (IDT) also increases. The increasing and decreasing nature of the initial deformation temperature (IDT) observed is also dependent upon the CaO and MgO contents. XRD analysis of the coal samples revealed significant changes in mineral matter contents with the types of beneficiation processes adopted for coal. The minerals like chlorite, illite, montmorillonite, pyrite, calcite, aragonite, and alumina have been removed during the beneficiation processes. The FTIR spectra also indicate the presence of minerals like gypsum (G), calcite (C) aragonite (Ar), quartz (Q) and kaolinite (K) in the raw coal and their subsequent removal after the beneficiation processes.
The Assessment of Slope Stability along NH-22 in Rampur-Jhakri Area, Himachal Pradesh
Authors: Sarkar Kripamoy , Singh Ashok Kumar , Niyogi Anurag , Behera Prasanta Kumar , Verma A. K. , Singh T. N. 
Published: September 2016

Abstract:
The present paper demonstrates the assessment of slope stability analysis between Rampur to Jhakri road section along National Highway (NH-22), Himachal Pradesh, India. The different types of slope failures have affected most part of slopes which causes considerable loss of life and property, inconveniences such as disruption of traffic along highways. The poorly designed rock slopes for road widening or construction purposes may weaken the stability of the slopes. A detail field investigation has been carried out to collect the representative rock samples for determination of physico-mechanical properties of rock and joint data for kinematic analysis. The rocks exposed in the area are highly jointed quartzite and quartz-mica schist of Rampur-Larji Group of Palaeoproterozoic age. The continuous slope mass rating (CSMR) technique has been applied for the assessment of slope stability analysis at five vulnerable locations and the results shows slopes are partially stable to unstable. Kinematic analysis mainly shows wedge type of failure along with few toppling and planar failures. The existing slope required immediate treatment to prevent the failure for its long term stability.
Rehabilitation Trends After Lower Extremity Amputations in Canada
Authors: Kayssi Ahmed , Dilkas Steven , Dance Derry L. , de Mestral Charles , Forbes Thomas L. , Roche‐Nagle Graham 
Published: September 2016

AbstractBackgroundThe heterogeneity of medical complications that lead to amputation has resulted in a diverse patient population with differing rehabilitation needs; however, the rehabilitation trends for patients with lower extremity amputations across Canada have not been studied previously.ObjectiveTo describe trends in rehabilitation after lower extremity amputations and the factors affecting rehabilitation length of stay in Canada.DesignRetrospective cohort analysis.SettingCanadian inpatient rehabilitation facilities that received persons with lower extremity amputations discharged from academic or community hospitals.ParticipantsPatients underwent lower extremity amputations between 2006 and 2009 for nontraumatic indications and were then discharged to a rehabilitation facility. Patients were identified from the Canadian Institute for Health Information's Discharge Abstract Database that includes hospital admissions across Canada except Quebec.InterventionsInpatient rehabilitation after lower extremity amputations.Main Outcome MeasuresLength of stay, discharge destination, and change in total and motor function scores.ResultsThe analysis included 5342 persons who underwent lower extremity amputations, 1904 of whom were transferred to a rehabilitation facility (36%). Patients most commonly underwent single below‐knee (74%) and above‐knee (17%) amputations. The duration of rehabilitation varied by whether the amputation was performed by a vascular (median = 36 days), orthopedic (median = 38 days), or general surgeon (median = 35 days). The overall median length of stay was 36 days. Most patients (72%) subsequently were discharged home and 9% were readmitted to hospital. Predictors of longer rehabilitation included amputation by an orthopedic surgeon (beta = 5.0, P ≤ .01), older age (beta = 0.2, P ≤ .01), and a history of ischemic heart disease (beta = 3.8, P = .03) or congestive heart failure (beta = 5, P = .04). Patients who spent <7 days in hospital were significantly more likely to have a shorter rehabilitation stay (beta = −4, P = .03). Advanced patient age was the only predictor for hospital readmission (odds ratio = 1.03, P ≤ .01).ConclusionsRehabilitation length of stay in Canada after lower extremity amputation varies by the type of surgeon performing the amputation. Advanced age, undergoing surgery in the province of Manitoba, and having a history of ischemic heart disease or congestive heart failure predict a longer rehabilitation stay. A shorter perioperative hospitalization period (<7 days) predicts a shorter rehabilitation duration. Future studies are needed to explore these issues and to optimize the delivery of rehabilitation services to Canadians after lower extremity amputation.Level of EvidenceII
Heidegger and the Supposed Meaninglessness of Personal Immortality
Authors: BUBEN ADAM 
Published: September 2016

ABSTRACT:For several decades now, a debate about the desirability of immortality has raged on in philosophy of death circles. While these circles and their debates are found primarily within the analytic tradition, Martin Heidegger, who famously introduces the notion of human life (or something like it) as essentially ‘Being-towards-death’, has much to contribute. At first glance, this idea seems to agree with the views of ‘immortality curmudgeons’ like Samuel Scheffler, and, in fact, on the rare occasions that Heidegger is mentioned in the related literature, his name is usually placed on a list of likely pessimists about immortality. Upon closer inspection, however, it turns out that Heidegger's understanding of the relationship between death and meaning allows for a rather uncurmudgeonly view of immortality. In this paper, I argue that the often-misunderstood Heidegger has important supportive insights to offer when it comes to the prospects of an unending life.
Bystander fatigue and CPR quality by older bystanders: a randomized crossover trial comparing continuous chest compressions and 30:2 compressions to ventilations
Authors: Liu Shawn , Vaillancourt Christian , Kasaboski Ann , Taljaard Monica 
Published: September 2016

ABSTRACTObjectivesThis study sought to measure bystander fatigue and cardiopulmonary resuscitation (CPR) quality after five minutes of CPR using the continuous chest compression (CCC) versus the 30:2 chest compression to ventilation method in older lay persons, a population most likely to perform CPR on cardiac arrest victims.MethodsThis randomized crossover trial took place at three tertiary care hospitals and a seniors’ center. Participants were aged ≥55 years without significant physical limitations (frailty score ≤3/7). They completed two 5-minute CPR sessions (using 30:2 and CCC) on manikins; sessions were separated by a rest period. We used concealed block randomization to determine CPR method order. Metronome feedback maintained a compression rate of 100/minute. We measured heart rate (HR), mean arterial pressure (MAP), and Borg Exertion Scale. CPR quality measures included total number of compressions and number of adequate compressions (depth ≥5 cm).ResultsSixty-three participants were enrolled: mean age 70.8 years, female 66.7%, past CPR training 60.3%. Bystander fatigue was similar between CPR methods: mean difference in HR -0.59 (95% CI −3.51-2.33), MAP 1.64 (95% CI −0.23-3.50), and Borg 0.46 (95% CI 0.07-0.84). Compared to 30:2, participants using CCC performed more chest compressions (480.0 v. 376.3, mean difference 107.7; p<0.0001) and more adequate chest compressions (381.5 v. 324.9, mean difference. 62.0; p=0.0001), although good compressions/minute declined significantly faster with the CCC method (p=0.0002).ConclusionsCPR quality decreased significantly faster when performing CCC compared to 30:2. However, performing CCC produced more adequate compressions overall with a similar level of fatigue compared to the 30:2 method.
Comparison of enteric protozoan infections in four Australian hospitals: variable tests and variable results
Authors: FLETCHER-LARTEY STEPHANIE M. , ANDRESEN DAVID , VAN HAL SEBASTIAN , MERIF JUAN , STARK DAMIEN , RAWLINSON WILLIAM , HARKNESS JOHN , ELLIS JOHN 
Published: September 2016

SUMMARYThere is limited evidence of the prevalence of enteric protozoon infections in developed settings. We estimated the prevalence of enteric protozoa and evaluated the outcome of testing algorithms used in hospital settings in Sydney, Australia. This retrospective study assessed microbiological data from four public clinical laboratories. Pooled data from the four hospitals revealed the most common enteric protozoon detected wasBlastocystisspp. in an average of 5·4% of cases, followed byGiardia intestinalis(1·1%) andDientamoeba fragilis(0·8%). Protozoon detection rates between hospitals were significantly different and could be based on multiple factors. The modified iron haematoxylin staining method, consistently detected higher rates ofBlastocystisspp., andG. intestinalisin comparison with microscopy of wet preparations, as well as higher rates ofG. intestinalisandCryptosporidiumwhen compared with enzyme immunoassay. The study concludes that there are multiple factors that contribute to the variability in protozoa detection rates in metropolitan hospitals, including widespread variability in the testing protocols for enteric protozoa, individual and population characteristics. A gold standard approach for diagnosis of enteric protozoa is recommended. Molecular diagnostic methods such as polymerase chain reaction would provide consistency across laboratories and yield more reliable estimates of the actual prevalence of enteric protozoa.
Male-killing symbiont damages host’s dosage-compensated sex chromosome to induce embryonic apoptosis
Authors: Harumoto Toshiyuki , Anbutsu Hisashi , Lemaitre Bruno , Fukatsu Takema 
Published: September 2016

AbstractSome symbiotic bacteria are capable of interfering with host reproduction in selfish ways. How such bacteria can manipulate host’s sex-related mechanisms is of fundamental interest encompassing cell, developmental and evolutionary biology. Here, we uncover the molecular and cellular mechanisms underlyingSpiroplasma-induced embryonic male lethality inDrosophila melanogaster. Transcriptomic analysis reveals that many genes related to DNA damage and apoptosis are up-regulated specifically in infected male embryos. Detailed genetic and cytological analyses demonstrate that male-killingSpiroplasmacauses DNA damage on the male X chromosome interacting with the male-specific lethal (MSL) complex. The damaged male X chromosome exhibits a chromatin bridge during mitosis, and bridge breakage triggers sex-specific abnormal apoptosis via p53-dependent pathways. Notably, the MSL complex is not only necessary but also sufficient for this cytotoxic process. These results highlight symbiont’s sophisticated strategy to target host’s sex chromosome and recruit host’s molecular cascades toward massive apoptosis in a sex-specific manner.
Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways
Authors: Kikuchi Ippei , Takahashi-Kanemitsu Atsushi , Sakiyama Natsuki , Tang Chao , Tang Pei-Jung , Noda Saori , Nakao Kazuki , Kassai Hidetoshi , Sato Toshiro , Aiba Atsu , Hatakeyama Masanori 
Published: September 2016

AbstractEvolutionally conserved Wnt, Hedgehog (Hh) and Notch morphogen pathways play essential roles in the development, homeostasis and pathogenesis of multicellular organisms. Nevertheless, mechanisms that intracellularly coordinate these signal inputs remain poorly understood. Here we found that parafibromin, a component of the PAF complex, competitively interacts with β-catenin and Gli1, thereby potentiating transactivation of Wnt- and Hh-target genes in a mutually exclusive manner. Parafibromin also binds to the Notch intracellular domain (NICD), enabling concerted activation of Wnt- and Notch-target genes. The transcriptional platform function of parafibromin is potentiated by tyrosine dephosphorylation, mediated by SHP2 phosphatase, while it is attenuated by tyrosine phosphorylation, mediated by PTK6 kinase. Consequently, acute loss of parafibromin in mice disorganizes the normal epithelial architecture of the intestine, which requires coordinated activation/inactivation of Wnt, Hh and/or Notch signalling. Parafibromin integrates and converts signals conveyed by these morphogen pathways into appropriate transcriptional outputs in a tyrosine phosphorylation/dephosphorylation-regulated manner.
The DNA cytosine deaminase APOBEC3H haplotype I likely contributes to breast and lung cancer mutagenesis
Authors: Starrett Gabriel J. , Luengas Elizabeth M. , McCann Jennifer L. , Ebrahimi Diako , Temiz Nuri A. , Love Robin P. , Feng Yuqing , Adolph Madison B. , Chelico Linda , Law Emily K. , Carpenter Michael A. , Harris Reuben S 
Published: September 2016

AbstractCytosine mutations within TCA/T motifs are common in cancer. A likely cause is the DNA cytosine deaminase APOBEC3B (A3B). However, A3B-null breast tumours still have this mutational bias. Here we show that APOBEC3H haplotype I (A3H-I) provides a likely solution to this paradox. A3B-null tumours with this mutational bias have at least one copy of A3H-I despite little genetic linkage between these genes. Although deemed inactive previously, A3H-I has robust activity in biochemical and cellular assays, similar to A3H-II after compensation for lower protein expression levels. Gly105 in A3H-I (versus Arg105 in A3H-II) results in lower protein expression levels and increased nuclear localization, providing a mechanism for accessing genomic DNA. A3H-I also associates with clonal TCA/T-biased mutations in lung adenocarcinoma suggesting this enzyme makes broader contributions to cancer mutagenesis. These studies combine to suggest that A3B and A3H-I, together, explain the bulk of ‘APOBEC signature’ mutations in cancer.
Spatiotemporal dynamics of lesion-induced axonal sprouting and its relation to functional architecture of the cerebellum
Authors: Dhar Matasha , Brenner Joshua M. , Sakimura Kenji , Kano Masanobu , Nishiyama Hiroshi 
Published: September 2016

AbstractNeurodegenerative lesions induce sprouting of new collaterals from surviving axons, but the extent to which this form of axonal remodelling alters brain functional structure remains unclear. To understand how collateral sprouting proceeds in the adult brain, we imaged post-lesion sprouting of cerebellar climbing fibres (CFs) in mice using in vivo time-lapse microscopy. Here we show that newly sprouted CF collaterals innervate multiple Purkinje cells (PCs) over several months, with most innervations emerging at 3–4 weeks post lesion. Simultaneous imaging of cerebellar functional structure reveals that surviving CFs similarly innervate functionally relevant and non-relevant PCs, but have more synaptic area on PCs near the collateral origin than on distant PCs. These results suggest that newly sprouted axon collaterals do not preferentially innervate functionally relevant postsynaptic targets. Nonetheless, the spatial gradient of collateral innervation might help to loosely maintain functional synaptic circuits if functionally relevant neurons are clustered in the lesioned area.
Resilience of bacterial quorum sensing against fluid flow
Authors: Emge Philippe , Moeller Jens , Jang Hongchul , Rusconi Roberto , Yawata Yutaka , Stocker Roman , Vogel Viola 
Published: September 2016

AbstractQuorum sensing (QS) is a population-density dependent chemical process that enables bacteria to communicate based on the production, secretion and sensing of small inducer molecules. While recombinant constructs have been widely used to decipher the molecular details of QS, how those findings translate to natural QS systems has remained an open question. Here, we compare the activation of natural and synthetic Pseudomonas aeruginosa LasI/R QS systems in bacteria exposed to quiescent conditions and controlled flows. Quantification of QS-dependent GFP expression in suspended cultures and in surface-attached microcolonies revealed that QS onset in both systems was similar under quiescent conditions but markedly differed under flow. Moderate flow (Pe > 25) was sufficient to suppress LasI/R QS recombinantly expressed in Escherichia coli, whereas only high flow (Pe > 102) suppressed QS in wild-type P. aeruginosa. We suggest that this difference stems from the differential production of extracellular matrix and that the matrix confers resilience against moderate flow to QS in wild-type organisms. These results suggest that the expression of a biofilm matrix extends the environmental conditions under which QS-based cell-cell communication is effective and that findings from synthetic QS circuits cannot be directly translated to natural systems.
Rigidity of silicone substrates controls cell spreading and stem cell differentiation
Authors: Vertelov Grigory , Gutierrez Edgar , Lee Sin-Ae , Ronan Edward , Groisman Alex , Tkachenko Eugene 
Published: September 2016

AbstractThe dependences of spreading and differentiation of stem cells plated on hydrogel and silicone gel substrates on the rigidity and porosity of the substrates have recently been a subject of some controversy. In experiments on human mesenchymal stem cells plated on soft, medium rigidity, and hard silicone gels we show that harder gels are more osteogenic, softer gels are more adipogenic, and cell spreading areas increase with the silicone gel substrate rigidity. The results of our study indicate that substrate rigidity induces some universal cellular responses independently of the porosity or topography of the substrate.