bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing the accuracy of genus-level data to predict species diversity in Cenozoic marine diatoms
Authors: Wiese Robert , Renaudie Johan , Lazarus David B. 
Published: October 2016

Abstract
Correlations between past biotic diversity and climate can inform humanity’s response to predictions of future global climate change, e.g., extinction risk with global warming. Paleodiversity studies, however, frequently use genera as a proxy for species diversity, a practice that has often been questioned. Tests using actual data of the impact of using species-level versus genus-level taxonomy in paleodiversity-paleoenvironmental studies are also lacking. We conduct such a test, based on a recent study that showed a strong correlation of Cenozoic marine planktonic diatom species diversity to geochemical climate proxies. Using an updated version of the data set, we still find a strong correlation of Cenozoic diatom species diversity to environment. Using identical data but instead genera results in the loss of all significant correlations of diversity to environmental change. This occurs due to the earlier rise and later stability in genus versus species diversity data, a pattern known to be common between taxonomic ranks in the fossil record, and in general models of diversification. We conclude that studies of paleodiversity, particularly those addressing biotic responses to future environmental change, need to demonstrate the adequacy of genera as a proxy for species diversity, or use species-level data.
Breathing more deeply: Deep ocean carbon storage during the mid-Pleistocene climate transition
Authors: Lear Caroline H. , Billups Katharina , Rickaby Rosalind E.M. , Diester-Haass Liselotte , Mawbey Elaine M. , Sosdian Sindia M. 
Published: October 2016

Abstract
The ∼100 k.y. cyclicity of the late Pleistocene ice ages started during the mid-Pleistocene transition (MPT), as ice sheets became larger and persisted for longer. The climate system feedbacks responsible for introducing this nonlinear ice sheet response to orbital variations in insolation remain uncertain. Here we present benthic foraminiferal stable isotope (δ18O, δ13C) and trace metal records (Cd/Ca, B/Ca, U/Ca) from Deep Sea Drilling Project Site 607 in the North Atlantic. During the onset of the MPT, glacial-interglacial changes in δ13C values are associated with changes in nutrient content and carbonate saturation state, consistent with a change in water mass at our site from a nutrient-poor northern source during interglacial intervals to a nutrient-rich, corrosive southern source during glacial intervals. The respired carbon content of glacial Atlantic deep water increased across the MPT. Increased dominance of corrosive bottom waters during glacial intervals would have raised mean ocean alkalinity and lowered atmospheric pCO2. The amplitude of glacial-interglacial changes in δ13C increased across the MPT, but this was not mirrored by changes in nutrient content. We interpret this in terms of air-sea CO2 exchange effects, which changed the δ13C signature of dissolved inorganic carbon in the deep water mass source regions. Increased sea ice cover or ocean stratification during glacial times may have reduced CO2 outgassing in the Southern Ocean, providing an additional mechanism for reducing glacial atmospheric pCO2. Conversely, following the establishment of the ∼100 k.y. glacial cycles, δ13C of interglacial northern-sourced waters increased, perhaps reflecting reduced invasion of CO2 into the North Atlantic following the MPT.
Medical claims-based case–control study of temporal relationship between clinical visits for hand syndromes and subsequent diabetes diagnosis: implications for identifying patients with undiagnosed type 2 diabetes mellitus
Authors: Hou Wen-Hsuan , Li Chung-Yi , Chen Lu-Hsuan , Wang Liang-Yi , Kuo Li-Chieh , Kuo Ken N , Shen Hsiu-Nien , Chiu Chang-Ta 
Published: October 2016

ObjectivesTo investigate whether a temporal relationship is present between clinical visits for diabetes-related hand syndromes (DHSs) and subsequent type 2 diabetes mellitus (T2DM) diagnosis and, accordingly, whether DHSs can be used for identifying patients with undiagnosed T2DM.DesignThis study had a case–control design nested within a cohort of 1 million people from the general population, which was followed from 2005 to 2010. The odds of prior clinical visits for DHSs, namely carpal tunnel syndrome (CTS), flexor tenosynovitis, limited joint mobility and Dupuytren's disease, were estimated for cases and controls. We used a conditional logistic regression model to estimate the OR and 95% CI of T2DM in association with a history of DHSs. The validity and predictive value of using the history of DHSs in predicting T2DM diagnosis were calculated.SettingTaiwan National Health Insurance medical claims.ParticipantsWe identified 33 571 patients receiving a new diagnosis of T2DM (cases) between 2005 and 2010. Each T2DM case was matched with 5 controls who had the same sex and birth year and were alive on the date of T2DM diagnosis.Primary and secondary outcome measuresThe primary outcome measure was T2DM diagnosis.ResultsThe OR of T2DM in association with prior clinical visits was significantly increased for overall DHS and CTS, being 1.15 (95% CI 1.10 to 1.20) and 1.22 (95% CI 1.16 to 1.29), respectively. Moreover, 11% of patients with T2DM made clinical visits for CTS within 3 months prior to T2DM diagnosis. The history of DHSs had low sensitivity (<0.1% to 5.2%) and a positive predictive value (9.9% to 11.7%) in predicting T2DM.ConclusionsDespite the unsatisfactory validity and performance of DHSs as a clinical tool for detecting patients with undiagnosed T2DM, this study provided evidence that clinical visits for DHSs, particularly for CTS, can be a sign of undiagnosed T2DM.
Quantifying the Dynamics of Field Cancerization in Tobacco-Related Head and Neck Cancer: A Multiscale Modeling Approach
Authors: Ryser Marc D. , Lee Walter T. , Ready Neal E. , Leder Kevin Z. , Foo Jasmine 
Published: October 2016

AbstractHigh rates of local recurrence in tobacco-related head and neck squamous cell carcinoma (HNSCC) are commonly attributed to unresected fields of precancerous tissue. Because they are not easily detectable at the time of surgery without additional biopsies, there is a need for noninvasive methods to predict the extent and dynamics of these fields. Here, we developed a spatial stochastic model of tobacco-related HNSCC at the tissue level and calibrated the model using a Bayesian framework and population-level incidence data from the Surveillance, Epidemiology, and End Results (SEER) registry. Probabilistic model analyses were performed to predict the field geometry at time of diagnosis, and model predictions of age-specific recurrence risks were tested against outcome data from SEER. The calibrated models predicted a strong dependence of the local field size on age at diagnosis, with a doubling of the expected field diameter between ages at diagnosis of 50 and 90 years, respectively. Similarly, the probability of harboring multiple, clonally unrelated fields at the time of diagnosis was found to increase substantially with patient age. On the basis of these findings, we hypothesized a higher recurrence risk in older than in younger patients when treated by surgery alone; we successfully tested this hypothesis using age-stratified outcome data. Further clinical studies are needed to validate the model predictions in a patient-specific setting. This work highlights the importance of spatial structure in models of epithelial carcinogenesis and suggests that patient age at diagnosis may be a critical predictor of the size and multiplicity of precancerous lesions. Cancer Res; 76(24); 7078–88. ©2016 AACR.
Potencial ornamental do Maciço Glória Norte, Domínio Macururé, Sistema Orogênico Sergipano
Authors: Lisboa Vinícius Anselmo Carvalho , Simões Caroline Bomfim Santana , Rios Débora Correia , Conceição Herbet 
Published: October 2016

“Granitos ornamentais” correspondem no mercado de rochas ornamentais a rochas que incluem tanto aquelas de origem ígnea quanto metamórfica. Isto reflete a informalidade do setor e sua independência dos conceitos teórico-acadêmicos que definem e classificam as rochas, já que a aceitação de um tipo litológico no mercado de rochas ornamentais depende, principalmente, de fatores estéticos e físicos, deixando muitas vezes de lado a avaliação das propriedades mineralógicas, texturais e estruturais. Este trabalho enfoca a avaliação do potencial de uso ornamental das rochas da Fácies Porfirítica (MP) do Maciço Glória Norte (MGN), em Sergipe, a partir de estudos petrográficos associados com a aplicação do Índice de Atratividade Econômico-Geológica (IAEG). Este índice vem sendo cada vez mais aplicado na avaliação do potencial ornamental de uma rocha a partir da qualificação e quantificação de uma série de critérios que consideram não só os aspectos de campo e mercadológicos, mas incluem a aplicação de estudos petrográficos e a observação de aspectos sobre a mineralogia, forma, dimensões, e relações de contato entre os minerais, bem como as alterações e deformações sofridas por aquele material. Os valores obtidos para o IAEG variam entre 54 e 63. Por sua vez, a determinação de alguns parâmetros físicos a partir do estudo petrográfico revelou a ausência de falhas e/ou fraturas expressivas, pouca alteração dos feldspatos e baixa quantidade de óxidos e sulfetos, o que agrega valor a este material na sua aplicação na construção civil. Os resultados aqui obtidos a partir da associação do IAEG com os parâmetros petrográficos e estruturais evidenciam um potencial ornamental médio a alto, sugerindo a possível utilização das rochas do MGN no mercado de rochas ornamentais, principalmente para os litotipos da Fácies MP. Ressalta-se, entretanto, que este uso comercial ainda exige a aplicação dos testes e ensaios tecnológicos, uma avaliação de mercado, e que haja um esforço dos órgãos competentes para fomentar a criação de uma cadeia ou arranjo produtivo para rochas ornamentais no Estado de Sergipe, que viabilize a sua explotação.
Modelo geométrico de fraturas e análise da tectônica rúptil aplicados ao estudo do fluxo do aquífero cristalino, São Paulo (SP)
Authors: Fernandes Amélia João , Fiume Bruna , Bertolo Reginaldo , Hirata Ricardo Cesar Aoki 
Published: October 2016

A análise detalhada de estruturas rúpteis é uma ferramenta ainda pouco utilizada no estudo de aquíferos fraturados, apesar de ser complementar aos dados obtidos em poços e de fornecer elementos de grande relevância para a elaboração de modelos conceituais de fluxo de água subterrânea. Este trabalho apresenta análise de dados coletados em pedreiras do Complexo Embu, visando elaborar modelo geométrico de fraturas em granitos e gnaisses pré-cambrianos, de modo a fornecer subsídios a projeto mais amplo de caracterização de contaminação de aquíferos por solventes organoclorados da área industrial do Jurubatuba, na cidade de São Paulo. Os dados coletados ao longo de scanlines, com correção do viés de orientação, e em observações pontuais, permitiram caracterizar grupos de fraturas, bem como seus respectivos campos de esforços e idades relativas. Os grupos subverticais de expressão regional são extrapoláveis para a área do Jurubatuba, complementando os dados obtidos em perfilagens de poços verticais. A transmissividade relativa dos grupos de fraturas é indicada pelo seu grau de intemperismo, presença de vegetação e de saídas de água. A pedreira constituída de gnaisses é o melhor análogo da geologia da área industrial. Sua foliação, afetada por dobra cilíndrica aberta e assimétrica, é de baixo a médio mergulho para SE ou NW e foi intensamente reativada como fraturas contínuas e de baixo mergulho, cuja transmissividade é relativamente elevada. Abundantes fraturas NW subverticais podem ser o principal caminho para o fluxo vertical. Fraturas subverticais NE são transmissivas, no entanto apresentam grande espaçamento e, por isso, são consideradas de menor importância para o fluxo, da mesma forma que as frequentes fraturas subverticais EW, de menor transmissividade relativa.
Polygenic Versus Monogenic Causes of Hypercholesterolemia Ascertained Clinically
Authors: Wang Jian , Dron Jacqueline S. , Ban Matthew R. , Robinson John F. , McIntyre Adam D. , Alazzam Maher , Zhao Pei Jun , Dilliott Allison A. , Cao Henian , Huff Murray W. , Rhainds David , Low-Kam Cécile , Dubé Marie-Pierre , Lettre Guillaume , Tardif Jean-Claude , Hegele Robert A. 
Published: October 2016

Objective—
Next-generation sequencing technology is transforming our understanding of heterozygous familial hypercholesterolemia, including revision of prevalence estimates and attribution of polygenic effects. Here, we examined the contributions of monogenic and polygenic factors in patients with severe hypercholesterolemia referred to a specialty clinic.

Approach and Results—
We applied targeted next-generation sequencing with custom annotation, coupled with evaluation of large-scale copy number variation and polygenic scores for raised low-density lipoprotein cholesterol in a cohort of 313 individuals with severe hypercholesterolemia, defined as low-density lipoprotein cholesterol >5.0 mmol/L (>194 mg/dL). We found that (1) monogenic familial hypercholesterolemia–causing mutations detected by targeted next-generation sequencing were present in 47.3% of individuals; (2) the percentage of individuals with monogenic mutations increased to 53.7% when copy number variations were included; (3) the percentage further increased to 67.1% when individuals with extreme polygenic scores were included; and (4) the percentage of individuals with an identified genetic component increased from 57.0% to 92.0% as low-density lipoprotein cholesterol level increased from 5.0 to >8.0 mmol/L (194 to >310 mg/dL).

Conclusions—
In a clinically ascertained sample with severe hypercholesterolemia, we found that most patients had a discrete genetic basis detected using a comprehensive screening approach that includes targeted next-generation sequencing, an assay for copy number variations, and polygenic trait scores.
UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses
Authors: Sasaki Naoto , Yamashita Tomoya , Kasahara Kazuyuki , Fukunaga Atsushi , Yamaguchi Tomoyuki , Emoto Takuo , Yodoi Keiko , Matsumoto Takuya , Nakajima Kenji , Kita Tomoyuki , Takeda Masafumi , Mizoguchi Taiji , Hayashi Tomohiro , Sasaki Yoshihiro , Hatakeyama Mayumi , Taguchi Kumiko , Washio Ken , Sakaguchi Shimon , Malissen Bernard , Nishigori Chikako , Hirata Ken-ichi 
Published: October 2016

Objective—
UVB irradiation is an established treatment for immunoinflammatory cutaneous disorders and has been shown to suppress cutaneous and systemic inflammatory diseases through modulation of the adaptive immune response. However, it remains unknown whether UVB irradiation prevents an immunoinflammatory disease of arteries such as atherosclerosis.

Approach and Results—

Here, we show that UVB exposure inhibits the development and progression of atherosclerosis in atherosclerosis-prone mice by expanding and enhancing the functional capacity of CD4
+
forkhead box P3
+
regulatory T cells and regulating proatherogenic T-cell responses. Experimental studies in Langerhans cell–depleted mice revealed that epidermal Langerhans cells play a critical role in UVB-dependent induction of CD4
+
forkhead box P3
+
regulatory T cells, suppression of proatherogenic T-cell responses, and prevention of atherosclerotic plaque development.

Conclusions—
Our findings suggest the skin immune system as a novel therapeutic target for atherosclerosis and provide a novel strategy for the treatment and prevention of atherosclerosis.
За следите от Методиевия превод на Книгата на пророк Йеремия
Authors: Мострова [Mostrova] Татяна [Tatiana] 
Published: October 2016

On traces of the Methodian translation of the Book of JeremiahThe article presents preliminary observations concerning the excerpts from the Book of Jeremiah in the Archival Chronograph (fifteenth century) and Vilno Chronograph (sixteenth century). According to their content, localization and linguistic characteristics, they fall into two main groups. Some of the excerpts are identified as chapters from the Slavic Prophetolo­gion and are connected with the translation made by Cyril and Methodius. Other chapters, which are not included in the Cyrillic and Glagolitic liturgical books, belong to the first, probably untranslated or now lost, part of the Book of Jeremiah. The excerpts that cannot be found in the Prophetologion also have archaic linguistic bases, connected to the translational techniques characteristic of the Cyrillo-Methodian translations, and differ considerably from the translation with commentaries that was made in Preslav. Whether these excerpts belong to an independent earlier translation, made by Methodius and his co-workers, or they are extracts from encyclopedic miscellany, they provide valuable material for the study of this biblical book and of the Old Bulgarian translation of the Old Testament. O śladach przekładu Księgi Jeremiasza autorstwa św. MetodegoArtykuł prezentuje wstępne obserwacje na temat fragmentów Księgi Jeremiasza, znaj­dujących się w zbiorach Archival Chronograph (XV wiek) i Vilno Chronograph (XVI wiek). Zgodnie z ich zawartością, miejscem powstania i cechami językowymi wchodzą one w skład dwóch głównych grup. Niektóre fragmenty są rozpoznane jako rozdziały słowiańskiego parimejnika i są związane z przekładem autorstwa śś. Cyryla i Metodego. Inne rozdziały, które nie weszły w skład cyrylickich i głagolickich ksiąg liturgicznych, należą do pierwszej, prawdopodobnie nieprzetłumaczonej lub zaginionej, części Księgi Jeremiasza. Fragmenty, które nie znajdują się w parimejniku, także mają archaiczną podstawę językową, związaną z technikami translatorskimi, charakterystycznymi dla przekładów cyrylometodejskich i znacznie różnią się od przekładu z komentarzami, powstałego w Presławiu. Bez względu na to, czy fragmenty te są częścią wcześniejszego, niezależnego tłumaczenia wykonanego przez Metodego i jego współpracowników, czy są fragmentami z encyklopedycznego miscellaneum, stanowią ważny punkt odniesienia do badania tej biblijnej księgi, a także starobułgarskiego przekładu Starego Testamentu.
Парадоксалната българска рецепция на Библията през епохата на Възраждането
Authors: Аретов [Aretov] Николай [Nikolaĭ] 
Published: October 2016

Paradoxical Bulgarian reception of the Bible during the National RevivalThis paper is focused on the difficulties that Bulgarian reception of the Bible encountered in nineteenth century – the lack of older canonical translations and the opposition of the Ecumenical Patriarchate against new translations, which were associated with Protestantism. Some instances that illustrate the ideas of the Bulgarians from that period are presented. One of them is from Two Brothers (Dvama bratya; 1888–1889) by Iliya Blaskov – a semi-documental novel dealing with the fates of the author’s family. The author concludes that the image of the Holy Scripture that even pious teachers had at that time was vague and closer to folklore than to modern biblical notions. Paradoksalna bułgarska recepcja Biblii w czasie odrodzenia narodowegoArtykuł prezentuje problemy bułgarskiej recepcji Biblii w XIX wieku – brak starszego tłumaczenia kanonicznego, a także opór Patriarchatu Konstantynopola wobec nowego przekładu kojarzonego z protestantyzmem. W pracy omówiono kilka przykładów bułgarskich koncepcji przekładu Pisma Świętego. Jedna z nich pochodzi z utworu Двама братя (1888–1889) Ilii Błyskowa – quasi-dokumentalnej powieści opowiadającej o losach rodziny autora. Okazuje się, że obraz Pisma Świętego, jaki mieli w tamtym czasie działacze bułgarskiego odrodzenia narodowego, był bardzo mglisty i bliższy folklorowi aniżeli nowoczesnym kategoriom.
Наблюдения върху лексикалната вариативност при библейските цитати в Йоан-Екзарховия превод на De Fide Orthodoxa
Authors: Илиева [Ilieva] Татяна [Tatiana] 
Published: October 2016

Observations on the theological terminology in the biblical quotations in John the Exarch’s translation of De Fide OrthodoxaThe paper presented here aims at comparing the theological terms as used, on the one hand, in the biblical quotations in John the Exarch’s translation of De fide orthodoxa and, on the other, in the Old Bulgarian (Grigirovich Prophetologion, Codex Marianus, Codex Zographiensis, Sinai Psalter, Enina Apostolos) as well as in some Middle Bulgarian (Bologna Psalter, Karpinski Apostolos, Ohridski Apostolos) Old Russian (Mstislav Gospels, Yurievski Gospels, Pogodinov Psalter, Chudov Psalter, Tolstoev Apostolos, Hristinopol Apostolos) and Old Serbia (Shishatovatski Apostolos, Matich Apostolos) monuments. Also taken in consideration are the respective parts in certain theological writings associated with the Preslav Literary Centre. Uwagi o terminologii teologicznej w cytatach z Biblii w przekładzie De Fide Orthodoxa Jana EgzarchyCelem artykułu jest porównanie terminologii teologicznej w cytatach biblijnych w przekładzie De fide othodoxa Jana Egzarchy, w starobułgarskich zabytkach językowych (Lekcjonarz Grigorowizca, Kodeks Mariański, Kodeks Zografski, Psałterz Synajski, Apostoł Eniński), w wybranych zabytkach średniobułgarskich (Psałterz Boloński, Apostoł Karpinski, Apostoł Ohrydzki), staroruskich (Ewangeliarz Mścisława, Ewangeliarz Jurjewski, Psałterz Pogodina, Psałterz Chłudowa, Apostoł Tołstoja, Apostoł Krystynopolski) i staroserbskich (Apostoł Sziszatowacki, Apostoł Maticia). Analizie poddano także poszczególne części wybranych pism teologicznych powstałych w presławskiej szkole piśmienniczej.
Kazalište kao stjecište kolektivne i privatne traume u Erigonu Jordana Plevneša
Authors: Baković Ivica 
Published: October 2016

Theatre as the confluence of the collective and private trauma in Erigon by Jordan PlevnešThe text problematizes the concept of national history and trauma in the play Erigon, written by the contemporary Macedonian playwright Jordan Plevneš. The starting point of the analysis are some peculiarities of Plevneš’s poetics and of the theatrical conceptions of Antonin Artaud that are central to Erigon as well as the problem of the representation (and performance) of history in drama and theatre. In Erigon one can recognize the critique of eurocentrism and the European centres of power along with their influence on the forma­tion of political and historical processes in Macedonia and the Balkans in general. The main question concerns the societal role of political theatre and its power. Teatr jako ujście zbiorowej i prywatnej traumy w Erigonie Jordana PlevnešaTekst prezentuje koncepcję historii narodowej i traumy w sztuce Erigon autorstwa współ­czesnego macedońskiego dramatopisarza – Jordana Plevneša. Punktem wyjścia do analizy są cechy charakterystyczne poetyki Autora oraz koncepcje teatralne Antonina Artauda, które zajmują w Erigonie miejsce centralne, podobnie jak problem reprezentacji (i performansu) historii w dramacie i teatrze. W Erigonie rozpoznać można krytykę eurocentryzmu obecnego w politycznych i historycznych procesach w Macedonii, a także ogólnie na Bałkanach. Główne pytanie dotyczy roli teatru politycznego i jego siły oddziaływania na społeczeństwo.