bluuebunny/crossref_metadata_2025_split huggingface dataset:
Replies to Nicholas Walker, Taylor Carman, and Peter Gordon
Authors: Macdonald Iain 
Published: September 2024

AbstractIn what follows, I present my replies to Nicholas Walker, Taylor Carman, and Peter Gordon's reflections on my What Would Be Different? Figures of Possibility in Adorno. I begin by summarizing what is at stake in the book. My reply to Nicholas Walker and Taylor Carman focusses on Adorno's criticisms of Heidegger, who claims that the history of metaphysics has blocked our access to an “other beginning” for thinking. This prepares the ground for a comparison of Adorno's and Heidegger's notions of what I call “blocked possibility.” My reply to Peter Gordon clarifies the relation of “blocked possibility” to actuality and, more specifically, to the actuality of happiness in Adorno's writings.
Microstructure of the cerebellum and its afferent pathways underpins dystonia in myoclonus dystonia
Authors: Tarrano Clément , Zito Giuseppe , Galléa Cécile , Delorme Cécile , McGovern Eavan M. , Atkinson‐Clement Cyril , Brochard Vanessa , Thobois Stéphane , Tranchant Christine , Grabli David , Degos Bertrand , Corvol Jean Christophe , Pedespan Jean‐Michel , Krystkowiak Pierre , Houeto Jean‐Luc , Degardin Adrian , Defebvre Luc , Didier Mélanie , Valabrègue Romain , Apartis Emmanuelle , Vidailhet Marie , Roze Emmanuel , Worbe Yulia 
Published: September 2024

AbstractBackground and PurposeMyoclonus dystonia due to a pathogenic variant in SGCE (MYC/DYT‐SGCE) is a rare condition involving a motor phenotype associating myoclonus and dystonia. Dysfunction within the networks relying on the cortex, cerebellum, and basal ganglia was presumed to underpin the clinical manifestations. However, the microarchitectural abnormalities within these structures and related pathways are unknown. Here, we investigated the microarchitectural brain abnormalities related to the motor phenotype in MYC/DYT‐SGCE.MethodsWe used neurite orientation dispersion and density imaging, a multicompartment tissue model of diffusion neuroimaging, to compare microarchitectural neurite organization in MYC/DYT‐SGCE patients and healthy volunteers (HVs). Neurite density index (NDI), orientation dispersion index (ODI), and isotropic volume fraction (ISOVF) were derived and correlated with the severity of motor symptoms. Fractional anisotropy (FA) and mean diffusivity (MD) derived from the diffusion tensor approach were also analyzed. In addition, we studied the pathways that correlated with motor symptom severity using tractography analysis.ResultsEighteen MYC/DYT‐SGCE patients and 24 HVs were analyzed. MYC/DYT‐SGCE patients showed an increase of ODI and a decrease of FA within their motor cerebellum. More severe dystonia was associated with lower ODI and NDI and higher FA within motor cerebellar cortex, as well as with lower NDI and higher ISOVF and MD within the corticopontocerebellar and spinocerebellar pathways. No association was found between myoclonus severity and diffusion parameters.ConclusionsIn MYC/DYT‐SGCE, we found microstructural reorganization of the motor cerebellum. Structural change in the cerebellar afferent pathways that relay inputs from the spinal cord and the cerebral cortex were specifically associated with the severity of dystonia.
N‐of‐1 trials in epilepsy: A systematic review and lessons paving the way forward
Authors: Defelippe Victoria M. , Brilstra Eva H. , Otte Willem M. , Cross Helen J. , O'Callaghan Finbar , De Giorgis Valentina , Poduri Annapurna , Lerche Holger , Sisodiya Sanjay , Braun Kees P. J. , Jansen Floor E. , Perucca Emilio 
Published: September 2024

AbstractObjectiveDefined as prospective single‐patient crossover studies with repeated paired cycles of active and control intervention, N‐of‐1 trials have gained attention as an option to obtain high‐quality evidence of efficacy, particularly for patients with rare epilepsies in whom conduction of well‐powered randomized controlled trials can be challenging. The objective of this systematic review is to provide an appraisal of the literature on N‐of‐1 trials in individuals with epilepsy.MethodsWe searched PubMed and Embase on January 12, 2024, for studies meeting the following criteria: prospectively planned, within‐patient, multiple‐crossover design in individuals with epilepsy and outcomes related to comorbidities. Information on design, outcome measurements, intervention, and analyses was retrieved. Risk of bias assessment was performed using the Risk of Bias in N‐of‐1 Trials (RoBiNT) scale. We highlighted methodological aspects of the N‐of‐1 trials identified and discuss future recommendations.ResultsFive studies met our inclusion criteria. An additional multiple‐crossover trial that evaluated treatment effects exclusively at group level was also included because of its relevance to N‐of‐1 study methodology. The studies enrolled individuals with focal seizures, absences or cognitive impairement and electrographic discharges. Treatments included established or investigational antiseizure medications, off‐label medications, neurostimulation or lifestyle intervention. Three of the five N‐of‐1 trials reported on individual cases. The studies' strengths were the use of individualized treatment dosages and symptom‐specific patient‐reported outcomes. Limitations were related to minimal reporting of baseline characteristics and seizure burden.SignificanceThe trials identified by our search exemplify how the N‐of‐1 design can be applied to assess interventions in individuals with epilepsy‐related disorders. Future N‐of‐1 trials of antiseizure interventions should take into account baseline seizure frequency, should apply statistical models suited to capture seizure frequency changes reliably and make predefined interim assessments. Non‐seizure outcome measures evaluable over short periods should be considered. Tailored N‐of‐1 methodology could pave the way to evidence‐based, treatment selection for patients with rare epilepsies.
Factors associated with poor sleep in children with drug‐resistant epilepsy
Authors: Proost Renee , Cleeren Evy , Jansen Bastiaan , Lagae Lieven , Van Paesschen Wim , Jansen Katrien 
Published: September 2024

AbstractObjectiveWe aimed to investigate sleep in children with drug‐resistant epilepsy (DRE), including developmental and epileptic encephalopathies (DEEs). Next, we examined differences in sleep macrostructure and microstructure and questionnaire outcomes between children with well‐controlled epilepsy (WCE) and children with DRE. Furthermore, we wanted to identify factors associated with poor sleep outcome in these children, as some factors might be targets to improve epilepsy and neurodevelopmental outcomes.MethodsA cross‐sectional study was conducted in children 4 to 18‐years‐old. Children without epilepsy, with WCE, and with DRE were included. Overnight electroencephalography (EEG), including chin electromyography and electrooculography, to allow sleep staging, was performed. Parents were asked to fill out a sleep questionnaire. Classical five‐stage sleep scoring was performed manually, spindles were automatically counted, and slow wave activity (SWA) in the first and last hour of slow wave sleep was calculated.ResultsOne hundred eighty‐two patients were included: 48 without epilepsy, 75 with WCE, and 59 with DRE. We found that children with DRE have significantly lower sleep efficiency (SE%), less time spent in rapid eye movement (REM) sleep, fewer sleep spindles, and a lower SWA decline over the night compared to children with WCE. Subjectively more severe sleep problems were reported by the caregivers and more daytime sleepiness was present in children with DRE. Least absolute shrinkage and selection operator (LASSO) regression showed that multifocal interictal epileptiform discharges (IEDs), benzodiazepine treatment, and longer duration of epilepsy were associated with lower SE% and lower REM sleep time. The presence of multifocal discharges and cerebral palsy was associated with fewer spindles. Benzodiazepine treatment, drug resistance, seizures during sleep, intellectual disability, and older age were associated with lower SWA decline.SignificanceBoth sleep macrostructure and microstructure are severely impacted in children with DRE, including those with DEEs. Epilepsy parameters play a distinct role in the disruption REM sleep, spindle count, and SWA decline.
Investigating EFL teacher agency in instructional practice of blended learning in Chinese higher education: An activity theory perspective
Authors: Rong Mi , Yao Yuan 
Published: September 2024

AbstractTeacher agency is considered a key driver of teacher professional growth, student improvement, and educational change. This study contributes to the sparse research on language teacher agency in blended learning (BL). Using activity theory to conceptualize teacher agency, this study explores how two English as a foreign language (EFL) teachers exerted agency while implementing BL at a Chinese university. This study also examines the factors that mediate the exercise of agency. Data were collected through classroom observations, interviews with both teachers and their students, and course documents to provide a thorough understanding of teachers’ experiences with blended teaching. The data analysis revealed that successful agentic actions to address contradictions included selecting the appropriate delivery to match learning goals, making good use of online tools for interaction, assigning students active roles, flexibly enacting rules, and building a supportive climate. However, some contradictions within the instructional activity system remain unresolved. Mediating factors such as tools (teachers’ expertise and beliefs), community (students and other professors), and rules (curriculum assessment) were found to shape teacher agency in the BL context. This study contributes to the literature on teacher agency in BL, and provides practical recommendations for teacher professional development and curriculum reform.
Peripheral intravenous catheter clinical care standard adherence in emergency departments: A qualitative study underpinned by the behaviour change wheel
Authors: Xu Hui , Bowdery Julie , To Yeng , Duff Jed , Griffin Bronwyn , Ullman Amanda J. , Rickard Claire M. , Plummer Karin 
Published: September 2024

AbstractAimTo explore the barriers and facilitators influencing emergency department clinicians' adherence to the Australian Peripheral Intravenous Catheter (PIVC) Clinical Care Standard, using the Behaviour Change Wheel (BCW).BackgroundSuboptimal PIVC practices are frequently linked to a range of patient‐important adverse outcomes. The first Australian Peripheral Intravenous Catheter Clinical Care Standard was introduced in 2021, aiming to standardize practice. However, a recent national survey revealed a lack of adherence to the Standard among emergency department clinicians.DesignA qualitative descriptive study.MethodThe study was conducted across two Australian emergency departments in 2023. Utilizing purposive sampling, semi‐structured interviews were conducted. The analysis incorporated both deductive and inductive approaches, mapping the findings to the BCW.FindingsInterviews with 25 nurses and doctors revealed nine key subthemes. The main barriers were the stressful environment, insufficient education and training, and the absence of a feedback mechanism. The main facilitators were recognition of suboptimal practice, belief in the importance of patient engagement, and the desire to improve practice.ConclusionMultiple complex factors have an impact on clinicians' adherence to the Standard. The identified interventions will serve as a guide for future implementation of the Standard.Implications for the Profession and Patient CareThe findings inform healthcare organizations of the significance of implementing strategies to enhance clinicians' acceptance of the Standard. Clinicians should consider incorporating the multifaceted interventions developed in accordance with the BCW for future implementation projects.ImpactPromoting adherence to standards opens avenues to challenge suboptimal practice and has the potential to instigate a culture shift in the fundamental skills of frontline clinicians.Reporting MethodThe study is designed and reported according to the Consolidated Criteria for Reporting Qualitative Research checklist.Patient or Public ContributionNo patient or public contribution.
Application of linaclotide in bowel preparation for colonoscopy in patients with constipation: A prospective randomized controlled study
Authors: Xu Haoxin , He Zhu , Liu Yulin , Xu Hong , Liu Pengfei 
Published: September 2024

AbstractBackground and AimColonoscopy plays a crucial role in the early diagnosis and treatment of colorectal cancer. Adequate bowel preparation is essential for clear visualization of the colonic mucosa and lesion detection. However, inadequate bowel preparation is common in patients with constipation, and there is no standardized preparation protocol for these patients. This study aimed to explore the effectiveness and tolerability of a pre‐colonoscopy combination regimen of linaclotide and polyethylene glycol (PEG).MethodsIn this prospective, single‐center, randomized controlled trial, 322 participants were divided into two groups: a 3‐L PEG + 870‐μg linaclotide group (administered as a single dose for 3 days) and a 4‐L PEG group. The primary endpoints were the Boston Bowel Preparation Scale (BBPS) score and the rate of adequate and excellent bowel preparation. Secondary endpoints were the rates of detection of colonic adenomas and polyps, cecal intubation rates, colonoscopy time, adverse reactions, patient satisfaction, and physician satisfaction.ResultsThe study included 319 patients. The 3‐L PEG + linaclotide group showed significantly higher rates of adequate and excellent bowel preparation than the 4‐L PEG group (89.4% vs 73.6% and 37.5% vs 25.3%, respectively; P < 0.05). The mean BBPS score for the right colon in the 3‐L PEG + linaclotide group was significantly higher than that in the 4‐L PEG group. There were no significant between‐group differences regarding the detection rates of colonic polyps and adenomas (44.4% vs 37.7% and 23.1% vs 20.1%, respectively; P > 0.05). There were no significant between‐group differences regarding cecal intubation rates, colonoscopy operation, and withdrawal times. However, patient tolerance and sleep quality were better in the 3‐L PEG + linaclotide group.ConclusionThe combination of 3‐L PEG and 870‐μg linaclotide, because of its lower volume of intake, can be considered as an alternative bowel preparation regimen for constipated patients undergoing colonoscopy, especially for the elderly.
Masculinity's (mis)fortune: Historicizing affect as extractivist infrastructure in Bolivian sodalite mining
Authors: Winchell Mareike 
Published: September 2024

AbstractHow is alienability produced as a mode of relation? Is capital a (racialized) affect? This article examines clashing expectations about minerals, specifically sodalite, at the Cerro Sapo mine in Ayopaya Bolivia. It describes how Cerro Sapo's current owner, a white Kenyan, engaged in narrative and bodily practices that sought to detach him from earlier labor histories and Indigenous demands for redistributive aid. Through a life history approach, the analysis centers one figure to provide insight into what capitalism looks like on the ground. This case sharpens scholarly understanding of the affective workings of extraction, highlighting the need to historicize feelings of trust and accountability by dis‐aggregating the figure of “the mine” and “the firm.” By illuminating Cerro Sapo's continuities with, and revisions to, colonial structures of racial violence and exchange, the article aims to advance studies of racial capitalism and add a new layer to public debates about colonial debts and reparations for slavery.
Deforesting the forest: Territory and relations in the Argentinean Chaco
Authors: Tola Florencia C. 
Published: September 2024

AbstractThis article examines in depth the nuances of the Toba (Qom) people's territorial claims over the Argentinean Chaco. Ethnographic fieldwork carried out from 1997 to the present in Qom communities in the center of the Argentinean Chaco allows me to analyze the relationships that these communities have maintained and continue maintaining with their territory since their insertion into the regional economy after the Chaco's colonization. The analysis of the alternation of destructive and protective practices shows us the Qom cosmological understandings of human‐forest relations and the ambiguities of their coexistence in which Indigenous people, the nation‐state, nongovernmental organizations (NGO), settlers, and nonhuman beings participate. I propose that the forest, rather than being seen by the Qom people as a common good to be protected amid a planetary crisis, is a relation within relations intersected by ambiguity. This article aims to contribute to studies on the particularities of Indigenous people standing against the destruction that the Anthropocene has brought, avoiding unitary ideas about the Anthropocene.
From BBB to PPP: Bioenergetic requirements and challenges for oligodendrocytes in health and disease
Authors: Fernandes Milton Guilherme Forestieri , Pernin Florian , Antel Jack P. , Kennedy Timothy E. 
Published: September 2024

AbstractMature myelinating oligodendrocytes, the cells that produce the myelin sheath that insulates axons in the central nervous system, have distinct energetic and metabolic requirements compared to neurons. Neurons require substantial energy to execute action potentials, while the energy needs of oligodendrocytes are directed toward building the lipid‐rich components of myelin and supporting neuronal metabolism by transferring glycolytic products to axons as additional fuel. The utilization of energy metabolites in the brain parenchyma is tightly regulated to meet the needs of different cell types. Disruption of the supply of metabolites can lead to stress and oligodendrocyte injury, contributing to various neurological disorders, including some demyelinating diseases. Understanding the physiological properties, structures, and mechanisms involved in oligodendrocyte energy metabolism, as well as the relationship between oligodendrocytes and neighboring cells, is crucial to investigate the underlying pathophysiology caused by metabolic impairment in these disorders. In this review, we describe the particular physiological properties of oligodendrocyte energy metabolism and the response of oligodendrocytes to metabolic stress. We delineate the relationship between oligodendrocytes and other cells in the context of the neurovascular unit, and the regulation of metabolite supply according to energetic needs. We focus on the specific bioenergetic requirements of oligodendrocytes and address the disruption of metabolic energy in demyelinating diseases. We encourage further studies to increase understanding of the significance of metabolic stress on oligodendrocyte injury, to support the development of novel therapeutic approaches for the treatment of demyelinating diseases.
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Functional diversity along the anteroposterior axis of the ventromedial hypothalamus
Authors: Gutierrez‐Castellanos Nicolas , Dias Inês C. , Husain Basma F. A. , Lima Susana 
Published: September 2024

AbstractInnate behaviors ensure animal survival and reproductive success. Defending their territory, escaping from predators or mating with a sexual partner, are fundamental behaviors determining the ecological fitness of individuals. Remarkably, all these behaviors share a common neural substrate, as they are under the control of the ventromedial hypothalamus (VMH). Decades of research have contributed to understanding the exquisite diversity of functional ensembles underlying the wide array of functions that the VMH carries out. These functional ensembles are usually distributed throughout the dorsoventral and mediolateral axes of this nucleus. However, increasing evidence is bringing to attention the functional diversity of the VMH across its anteroposterior axis. In this review, we will overview our current understanding of how different ensembles within the VMH control a wide array of animal behaviors, emphasizing the newly discovered roles for its anterior subdivision in the context of conspecific self‐defense.
Socioeconomic Deprivation Weighs Heavily on Liver Fibrosis and Mortality After Hepatitis C Cure (ANRS CO22 Hepather)
Authors: Barré Tangui , Parlati Lucia , Bourlière Marc , Ramier Clémence , Marcellin Fabienne , Protopopescu Camelia , Di Beo Vincent , Moins Cécile , Dorival Celine , Nicol Jérôme , Zucman‐Rossi Jessica , Mathurin Philippe , Larrey Dominique , Boursier Jérôme , Carrat Fabrice , Carrieri Patrizia ,   the ANRS/AFEF Hepather Study group
Published: September 2024

ABSTRACTAlthough Hepatitis C virus (HCV) infection can be cured with direct‐acting antivirals (DAA), some cured patients face a serious risk of advanced liver damage and early mortality. In order to avoid these two negative health outcomes, it is important to identify and assess related risk factors. Little is currently known about socioeconomic and behavioural factors in this context. Using data from the ANRS CO22 Hepather cohort, we tested for associations between socioeconomic and behavioural factors and (i) advanced liver fibrosis (defined as an FIB‐4 > 3.25) assessed longitudinally using a mixed‐effects logistic regression model (both the whole population and stratified on advanced liver fibrosis status at the time of HCV cure) and (ii) all‐cause mortality (Cox proportional hazards model), during post‐HCV cure follow‐up. Among 5833 participants cured of HCV, living in poverty was associated with postcure advanced liver fibrosis in participants without this diagnosis at the time of HCV cure (population attributable fraction—PAF—of 8.6%) and with mortality in the whole study population (PAF of 10.6%). The detrimental effects of unhealthy alcohol use and heavy tobacco smoking, as well as the beneficial effect of living with a stable partner were also highlighted. We highlighted the major role of poverty and behavioural factors in advanced liver fibrosis and all‐cause mortality in patients cured of HCV. Encouraging linkage to social support services and healthy behaviours after successful DAA treatment could limit morbidity and increase survival in this population.Clinical Trial Registration: ClinicalTrials.gov: NCT01953458
Turning the industrially relevant marine alga Nannochloropsis red: one move for multifaceted benefits
Authors: Liu Meijing , Yu Lihua , Zheng Jie , Shao Shengxi , Pan Yufang , Hu Hanhua , Shen Lili , Wang Wenda , Zhou Wenguang , Liu Jin 
Published: September 2024

Summary

Nannochloropsis oceanica is an industrially relevant marine microalga rich in eicosapentaenoic acid (EPA, a valuable ω‐3 polyunsaturated fatty acid), yet the algal production potential remains to be unlocked.

Here we engineered N. oceanica to synthesize the high‐value carotenoid astaxanthin independent of high‐light (HL) induction for achieving multifaceted benefits.

By screening β‐carotenoid ketolases and hydroxylases of various origins, and strategically manipulating compartmentalization, fusion patterns, and linkers of the enzyme pair, a remarkable 133‐fold increase in astaxanthin content was achieved in N. oceanica. Iterative metabolic engineering efforts led to further increases in astaxanthin synthesis up to 7.3 mg g−1, the highest reported for microalgae under nonstress conditions. Astaxanthin was found in the photosystem components and allowed the alga HL resistance and augmented EPA production. Besides, we achieved co‐production of astaxanthin and EPA by the engineered alga through a fed‐batch cultivation approach.

Our findings unveil the untapped potential of N. oceanica as a robust, light‐driven chassis for constitutive astaxanthin synthesis and provide feasible strategies for the concurrent production of multiple high‐value biochemicals from CO2, thereby paving the way for sustainable biotechnological applications of this alga.