bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuropharmacological and neurochemical evaluation of N-n-propyl-3-ethoxyquinoxaline-2-carboxamide (6n): a novel serotonergic 5-HT3 receptor antagonist for co-morbid antidepressant- and anxiolytic-like potential using traumatic brain injury model in rats
Authors: Bhatt Shvetank , Mahesh Radhakrishnan , Jindal Ankur , Devadoss Thangaraj 
Published: September 2016

Abstract

Background:
Several preclinical studies have shown that serotonergic 5-HT3 receptor antagonists play an important role in the management of neuropsychiatric disorders, such as depression and anxiety. In the present study the compound “6n” (N-n-propyl-3-ethoxyquinoxaline-2-carboxamide), a novel 5-HT3 receptor antagonist with an optimal log P (2.52) and pA

2
(7.6) value was screened for its neuro-pharmacological potential in chronic rodent models of depression and anxiety named traumatic brain injury (TBI).

Methods:
In this model, a 1 cm midline scalp incision was made, and the muscles were retracted to expose the skull. A stainless steel disc (10 mm in diameter and 3 mm in depth) was placed centrally between the lambda and bregma regions. The injury was induced using the impact acceleration model of TBI. Specifically, a 400 g metal weight was dropped from a height of 1 m guided by a straight pipe, onto the metal disc placed over the rat’s skull.

Results:
The behavioral anomalies of the TBI rats were attenuated by the chronic treatment of compound 6n (1 and 2 mg/kg, p.o.; 14 days) as observed by the modified open field test (ambulation, rearing, and fecal pellet), sucrose consumption test (% sucrose consumption), elevated plus maze [% open arm entries [OAE] and % time spent in open arm (TSOA)], and marble burying test (numbers). In addition, 6n also increased the levels of neurotransmitters (norepinephrine and serotonin) and brain derived neurotrophic factor (BDNF) in TBI rats.

Conclusions:
The result suggests that compound 6n exhibited antidepressant- and anxiolytic-like effects in rodent models of depression and anxiety.
MicroRNAs as regulatory elements in psoriasis
Authors: Liu Yuan , Liu Quanzhong 
Published: September 2016

Abstract
Psoriasis is a chronic, autoimmune, and complex genetic disorder that affects 23% of the European population. The symptoms of Psoriatic skin are inflammation, raised and scaly lesions. microRNA, which is short, nonprotein-coding, regulatory RNAs, plays critical roles in psoriasis. microRNA participates in nearly all biological processes, such as cell differentiation, development and metabolism. Recent researches reveal that multitudinous novel microRNAs have been identified in skin. Some of these substantial novel microRNAs play as a class of posttranscriptional gene regulator in skin disease, such as psoriasis. In order to insight into microRNAs biological functions and verify microRNAs biomarker, we review diverse references about characterization, profiling and subtype of microRNAs. Here we will share our opinions about how and which microRNAs are as regulatory in psoriasis.
Synthesis and 3D-AFM surface topology of nanographene-like material extracted from sulfonated tri-, di- and monochloroacetic acid
Authors: Elsabawy Khaled M. 
Published: September 2016

AbstractIn this study a graphene-like material was synthesized by chemical exfoliation of sieved graphite powder with an average particles size ≤100 µm in dispersing medium from tri-, di- and monochloroacetic acid sulfonated with 55 % H2SO3. The results indicated that the yield of graphene-like material was the best in case of trichloroacetic 55 % H2SO3, taking into account structure quality and amount of obtained material. Layered graphene-like material was carefully collected after reduction of GO formed by 50 % dimethylhydrazine. AFM-investigations were performed to characterize nanostructural features of produced graphene and expected surface area which is surface topology dependent. Furthermore, Raman spectra were measured to confirm graphene formation.
Depression, Psychotherapy, and Hispanic
Immigrant Charismatic Catholics in the U.S.
Authors: Jencks Lynn B. E. 
Published: September 2016

Abstract
The article engages the topic of the religious values of Hispanic immigrant charismatic
Catholics, or carismáticos, and how these values manifest when carismáticos suffer from chronic
depression. Their religious values prompt carismáticos to understand chronic depression as spiritual
misalignment, which in turn prompts spiritual realignment and religious healing as the most effective
means to address this mental illness. As a result, the carismáticos’ religious experiences lead them to
conclude that psychotherapy is ultimately ineffective. While the carismáticos are beginning to make
room for psychiatric medicine, they still perceive psychotherapists as holding values that irretrievably
conflict with charismatic religious values. Engaging Bergin’s 1980 article “Psychotherapy and Religious
Values,” this current article shares Bergin’s concern regarding the rift between religious values
and psychotherapist’s values, and suggests the need for a more communal, religious approach to
psychotherapy amongst practitioners of charismatic Catholicism.
Mary Sidney’s Translation of ṣeḏeq as ‛Just’
rather than ‛Righteous’
Authors: Willett Elizabeth Ann Remington 
Published: September 2016

Abstract
Mary Sidney’s (1561-1621) interesting and entertaining free translations of the Psalms using lyric
poetry forms prized by the Renaissance literary world highlight women’s roles often glossed over by male
translators. In addition, Mary Sidney chooses to translate Hebrew ṣeḏeq as ‛just’ in contrast to the King
James’s ‛righteous’, perhaps reflecting her concern for community justice, while the king spiritualized the
concept in order to protect his position and right to enforce royal wishes.
The Wildness of Creation: An Interpretation
of the Voice from the Whirlwind in Job
Authors: Nikkel David H. 
Published: September 2016

Abstract
The significance of God’s speaking through the voice from the whirlwind and Job’s subsequent
repentance has often been interpreted as a scolding by God for questioning divine providence and/or as
the assertion of inscrutable mystery. This paper offers an alternative hermeneutics consonant with an open
and relational understanding of the nature of God, arguing that Job can best be interpreted as a strong
endorsement of the unpredictability and wildness of nature, as God grants creation the freedom to act
according to its own integrity. This argument compares Elihu’s speech, which asserts divine complete
control of nature, with the voice from the whirlwind that asserts the wildness of rain and ice, of various
animals, and of the Behemoth and Leviathan, these latter associated with chaos. It concludes that Job, in
experiencing God in the wildness of the whirlwind, finds a new model of divine agency wherein God graces
creation with freedom.
Prospective Descriptive Study of RFID Tag Detection Rates based on Various Exploratory Scenarios Aimed at Identifying Optimal Conditions of Use
Authors: Petit Camille , Bergeron Maxime , Atkinson Suzanne , Lebel Denis , Bussières Jean-François 
Published: September 2016

AbstractObjectiveThe main objective is to evaluate RFID tags detection rates using various exploratory scenarios in order to identify optimal conditions of use. The secondary objective is to evaluate RFID tags detection rates based on a real-life scenario involving a cardiorespiratory resuscitation drug tray used within our institution in order to identify optimal conditions of use.BackgroundThe traceability of goods has been a subject of interest for more than a century. Traceability makes it possible to locate goods at every step in the chain from production through to disposal. Just as with other Automatic Identification and Data Capture technologies, radio frequency identification (RFID) is used to increase the traceability of objects.ResultsSeven variables that could influence RFID tags detection rates were evaluated in eight exploratory scenarios. Optimal detection parameters allowing to a 100 % detection rate were identified: a 10-second reading time; a reading distance of 10 cm; parallel orientation of reader-antenna and at least two back and forth readings for a total of 6 sec were required for optimal reading. Detection rates decreased after 100 RFID tags and it were not affected by the shape of the RFID tags. Reader-antenna and RFID tag interferences resulted from aluminum paper or RFID tags that touched one another. RFID tag detection rates obtained per operator were similar. Regarding real-life scenarios, detection rates increased with reading times and a plateau effect was observed after 10 sec. Undetected elements varied and non-detection was almost always related to the proximity of two RFID tags rather than the nature of the items read.ConclusionTo our knowledge, this is the first prospective descriptive study that compares RFID tag detection rates based on various exploratory scenarios in order to identify optimal conditions of use. Such results can be used to develop a software application supporting drug replenishing through RFID in the drug use process.
Vom Ausruf zum Aushang. Die KommunikationsformÖffentliche Bekanntmachungin Luxemburg (1795–1920): Eine text- und systemlinguistische Analyse
Authors: Moliner Olivier , Beyer Rahel 
Published: September 2016

AbstractThis article presents findings of the binational project “Language Standardization in Diversity: The case of German in Luxembourg (1795–1920)”. Point of departure is the general assumption that language contact and multilingualism figure prominently in language change (Heine and Kuteva 2005). However, their specific impact on language standardization understood as special type of language change (Mattheier, 1998) has scarcely been studied. This is also particularly valid for the history of text genres which have been described as the virtual ‘switch points’ between the history of language and the history of the language community (Mattheier, 1998). With a long history of multilingualism, Luxembourg constitutes a prime case for studying the impact of all these elements, i. e. language contact between Germanic varieties (i. e. Moselle-Franconian/emerging Luxembourgish, colloquial German) and between German and French. To investigate the process of standardization, the project mainly draws on a main corpus of 5.649 predominantly bilingual German/French public notices issued by the municipality of Luxembourg. Published as parallel texts in German and French, an important number of the public notices were produced by four different Luxembourgish printers. However, public notices defined as ‘form of communication’ (Schmitz, 2015) encompass different text genres, e. g. laws, regulations or auctions. Three notices are analyzed in detail concerning functional (Brinker et al. 2014), pragmatic (Klein, 2000) and linguistic aspects. Linguistically, certain constructions can be identified as typical for specific genres and for specific periods. In the text cluster of strongly normative texts, for instance, we find canonical formulas from (French) legal language. Corpus analysis of explanation-introducing ‘considérant que’ shows that their realization in the German column is variable at the beginning of the 19th century and also exhibits structural and lexical similarities with the French original. In the course of the century the formula is firstly expressed more uniformly, secondly adapted to German characteristics (towards nominal structures) and finally subject to lexical changes. After its emergence from the influence of French, the formula thus manages to develop autonomously.
Noninvasive Assessment of Skeletal Muscle Myosin Heavy Chain Expression in Trained and Untrained Men
Authors: Fry Andrew C. , Housh Terry J. , Cramer Joel B. , Weir Joseph P. , Beck Travis W. , Schilling Brian K. , Miller Jonathan D. , Nicoll Justin X. 
Published: September 2016

Abstract
Fry, AC, Housh, TJ, Cramer, JB, Weir, JP, Beck, TW, Schilling, BK, Miller, JD, and Nicoll, JX. Noninvasive assessment of skeletal muscle myosin heavy chain expression in trained and untrained men. J Strength Cond Res 31(9): 2355–2362, 2017—Numerous conditions and types of physical activity (e.g., exercise, aging, and muscle-related diseases) can influence muscle fiber types and the proteins expressed. To date, muscle fibers can only be characterized by actually obtaining a tissue sample using the invasive muscle biopsy procedure. Mechanomyography (MMG) is the assessment of the vibration properties of contracting skeletal muscle and has been proposed as a possible noninvasive method for muscle fiber analysis. Therefore, the purpose of this project was to examine the feasibility of using MMG and muscle performance measures to noninvasively assess muscle fiber characteristics. Fifteen men (5 endurance-trained, 5 weight-trained, and 5 sedentary) provided muscle samples from their vastus lateralis muscle. These samples were analyzed for relative myosin heavy chain (MHC) protein expression, which is highly correlated with % muscle fiber type areas. Additionally, each subject performed several muscle performance tests, and MMG of the quadriceps was assessed during a knee extension exercise. Multiple regression was used to develop prediction equations for determining relative muscle content of MHC types I, IIa, and IIx. A combination of MMG and knee extension performance variables estimated types I, IIa, and IIx MHCs with approximately 80% accuracy. Although preliminary, these data suggest that muscle performance tests in addition to MMG assessments during a simple muscle performance task (knee extension) can be used to estimate muscle fiber type composition in a healthy male population. Such methods could ultimately be used to noninvasively monitor muscle health and fitness.
Desarrollo de la herpetocultura en Costa Rica: Situación actual de herpetarios y manejo ex situ de reptiles y anfibios
Authors: Arias-Ortega Jazmín , Bonilla-Murrilo Fabián , Sasa Mahmood 
Published: September 2016

La tenencia de herpetofauna en cautiverio es una actividad que ha experimentado un enorme desarrollo en distintas partes del mundo, constituyéndose en la base de muchos programas de conservación, educación, e investigación. En Costa Rica, esta tendencia se evidencia en la proliferación de centros que mantienen reptiles y anfibios en las últimas dos décadas. Pese a este desarrollo, no hay disponible información centralizada sobre los herpetarios a nivel del país, por lo que se desconoce la forma como operan o los potenciales impactos que pudieran tener en la conservación de las especies mantenidas en ellos. En este trabajo se describen los centros que actualmente funcionan en el país, para lo cual se realizaron entrevistas a sus propietarios o regentes y visitas de conformación. Un total de 33 centros, que en conjunto albergan 144 especies, fueron encontrados. Este número de herpetarios resulta del desarrollo de la industria turística: la mayoría de ellos tienen como finalidad la exhibición de animales, aunque también algunos reportan fines educativos. Solo en cuatro centros se encontró clara evidencia de programas de investigación, pese a que la mayoría de herpetarios indicó la generación de conocimiento como uno de sus principales objetivos. Una proporción importante de establecimientos obtiene sus animales del medio, lo que supone un impacto en aquellas especies con poblaciones reducidas. Tal parece ser el caso de la matabuey Lachesis stenophrys, que se encontró en 66% de los centros, pese a ser una especie con poblaciones amenazadas en el país actualmente. La existencia de estos establecimientos demuestra el interés de nuestra sociedad por la tenencia de vida silvestre, y supone un interesante mosaico de experiencias, posibilidades y retos para la escena ambiental del país.
ABOUT THE ROBUSTNESS OF ADAPTIVE FEEDBACK LINEARIZATION CONTROLLER FOR INPUT PERTURBED UNCERTAIN FULLY-ACTUATED SYSTEMS
Authors: Chi Nguyen Van , Trung Nguyen Hien , Phuoc Nguyen Doan 
Published: September 2016

The paper proposes a theorem to assert the arbitrarily good robustness of the fully actuated mechanical system controlled by the adaptive feedback linearization controller. The fully actuated system to be controlled is considerately perturbed by input disturbances and contains constant uncertain parameters in its Euler-Lagrange forced model. It is shown in this paper that independent of input disturbances the adaptive feedback linearization controller with appropriately chosen parameters will drive the output of controlled systems to the desired trajectory for any arbitrary precision. The adaptive controller is applied to the two-link planar elbow arm robot with unknown mass of the end-effector of second link and input torque noises caused by the viscous friction forces and Coulomb friction terms. Simulation results show that the arbitrary precision of the tracking errors always are guaranteed.
PHENOLIC COMPOUNDS FROM CALLISTEMON CITRINUS LEAVES AND STEMS
Authors: Khanh Pham Ngoc , Đuc Ho Viet , Huong Tran Thu , Ha Vu Thi , Van Doan Thi , Son Ninh The , Kim Young Ho , Viet Do Quoc , Cuong Nguyen Manh 
Published: September 2016

In the search for bioactive constituents from Vietnamese plants, the leaves and stems of Callistemon citrinus (Curtis) Skeels were selected for chemical investigation. Phytochemical analysis of plant led to the isolation of eight phenolic compounds including two flavonoids (eucalyptine (1) and 8-demethyleucalyptine (2)), two alcohols (blumenol A (3), n-tetratriacontanol (4)), three benzoic acid derivatives (acid gallic (5), methyl gallate (6) protocatechuic acid (7)), one sterol (b-sitosterol (8)), and along with one sesquiterpene (2,6,10-bisabolatriene (9)). The structures of the natural compounds were determined by spectroscopic evidences including 1D- and 2D-NMR and ESI-MS.
GLUCOSIDES AND UREA DERIVATIVES FROM THE SEEDS OF SCAPHIUM MACROPODUM (MIQ.) BEUMÉE
Authors: Tu Vu Anh , Phan Nguyen Huu Toan , Diep Chau Ngoc , Duy Nong Van , Thuan Nguyen Thi Dieu , Thanh Nguyen Van , Cuong Nguyen Xuan , Nam Nguyen Hoai , Minh Chau Van 
Published: September 2016

Five known compounds {carbonylbis[imino(6-methyl-3,1-phenylenel)]}bis[carbamic acid] dimethyl ester (1), (1'R,3'S,5'R,8'S,2E,4E-dihydrophaseic acid) 3'-O-beta-D-glucopyranoside (2), 3-methylbutan-1-ol beta-D-glucopyranoside (3), astragalin (4) and daucosterol (5) were isolated from the methanol extract of the seeds of Scaphium macropodum (Miq.) Beumée. The structures of the isolated compounds were elucidated by the spectroscopic methods including NMR and MS, and also by comparison with the literature data. Compounds 1-3 were isolated from this plant for the first time.
FLAVONOIDS AND TRITERPENOIDS FROM CALLISTEMON CITRINUS AND THEIR INHIBITORY EFFECT ON NO PRODUCTION IN LPS-STIMULATED RAW264.7 MACROPHAGES
Authors: Cuong Nguyen Manh , Khanh Pham Ngoc , Duc Ho Viet , Huong Tran Thu , Kim Youn-Chui , Long Pham Quoc , Kim Young Ho 
Published: September 2016

Phytochemical investigation of the leaves and stems of Callistemon citrinus (Curtis) Skeels led to the isolation of 12 flavonoid and triterpenoid compounds, including one new flavonoid, callistine A (1) and six known flavonoids 6,7- dimethyl-5,7-dihydroxy-4’-methoxy flavone (2), astragalin (3), quercetin (4), catechin (5), eucalyptin (6), and 8-demethyleucalyptin (7), along with 5 triterpenoids, 3-β-acetylmorolic acid (8), 3β-hydroxy-urs-11-en-13(28)-olide (9), betulinic acid (10), diospyrolide (11) and ursolic acid (12). Their chemical structures were determined from the spectroscopic evidences counting 1D- and 2D-NMR and HR-MS data. All the isolated compounds were examined for their anti-inflammatory activity against LPS-activated NO production in macrophage RAW264.7 cells. Among them, quercetin (4) and 3β-hydroxy-urs-11-en-13(28)-olide (9) showed potential inhibition activity in nitric oxide (NO) production in RAW264.7 cells exposed to LPS.
Synthesis of hydroxyl terminated liquid natural rubber by oxidative depolymerization of deproteinized natural rubber
Authors: Giang Le Duc , Thao Dinh Long Mong , Huong Hoang Thi , Thu Hiep Le Thi 
Published: September 2016

Hydroxyl terminated liquid natural rubber (HTLNR) was prepared by the depolymerization of deproteinized natural rubber (DPNR) in mixture of toluene and water at 60oC for 24 hours in the presence of ammonium persulfate as an initiator and tetrahydrofuran (THF) as a homogenizing agent. GPC analysis revealed that the number-average molecular weight (Mn) and weight-average molecular weight (Mw) of HTLNR were found to be 4.334×103 g/mol and 11.702×103 g/mol, respectively, with polydispersity index (PDI) of 2.7. The chemical structure of HTLNR was determined by FTIR and 1H-NMR and 13C-NMR spectroscopic analysis. The mechanism of depolymerization and hydroxylation of NR to form HTNR based on the analytical data is also suggested in this study.
Differential involvement of ascorbate and guaiacol peroxidases in soybean drought resistance
Authors: Moloi Makoena J. , Mwenye Obed J. , Van der Merwe Rouxlene 
Published: September 2016

Soybean (Glycine max L.) is a small but growing component of the agricultural economy of South Africa and is predicted to become a major crop in Africa because of its high protein content. Drought induction at flowering or early stages of pod development has detrimental effects on soybean yield. As antioxidative enzymes play a protective role in plants during various abiotic stress conditions, this study was conducted to investigate how ascorbate (Enzyme Commission (EC) number 1.11.1.1) and guaiacol (EC: 1.11.1.7) peroxidases are involved in soybean drought resistance at different maturity stages (flowering and pod development). We also investigated whether the levels of these enzymes decline with plant maturity. Three tolerant soybean genotypes (G1, G2, G3) and a susceptible genotype (G4*) were used. These cultivars were categorised according to their sensitivity to drought stress in previous studies. The activity of ascorbate peroxidase was significantly induced by drought stress at both growth stages with higher activity in the resistant than susceptible plants, strongly supporting the protective role of this enzyme against drought stress at both developmental stages. The guaiacol peroxidase activity was induced to higher levels in the resistant than in the susceptible plants at flowering only, with no significant increase observed at pod development stage, indicating its selective protective involvement against drought stress. Interestingly, the levels of these enzyme activities were induced in all cultivars at both developmental stages, irrespective of drought stress, indicating that their activities increased with maturity.

Significance:

Guaiacol peroxidase is selectively involved in soybean drought resistance at flowering stage.
The upregulation of ascorbate peroxidase activity at both growth stages in drought-resistant cultivars suggests that this enzyme could be used as a biochemical marker of drought resistance in soybeans.
In contrast to the literature, activities of both enzymes increased with maturity irrespective of whether the plant is drought susceptible or resistant.