bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacted Lower Second Permanent Molars at the Ramus and Coronoid Process: A New Clinical Symptom of the WNT10A Mutation in Ectodermal Dysplasia
Authors: Aboujaoude Samia 
Published: December 2017

ABSTRACTAimHidrotic ectodermal dysplasia (ED) with the WNT10A mutation produces variable dentofacial symptoms. The aim of this study was to describe a new clinical symptom, i.e., specific to the WNT10A mutation in hidrotic ED. The study investigated the migratory trend of the lower second permanent molars to the ramus or coronoid process. To the best of authors' knowledge, no data in the literature describe this trend in cases of hidrotic ED.Materials and methodsA three-generation family pedigree was established for seven families after the diagnosis of hidrotic ED in a 10-year-old boy. Thereafter, a genetic and clinical study was conducted on three families with at least one individual affected by hidrotic ED (20 individuals). We selected the children with molar germs 37 and 47. The eruption axes of these germs were then traced on the panoramic images at the initial time (T0) and 1 year later (T0+ 1 year), and the deviations between these axes were measured.ResultsA significant familial consanguinity was shown. Eight subjects presented with the hidrotic ED phenotype. Among them, three individuals carried germs 37 and 47. Over time, the measured deviations between the eruption axes of the latter displayed, in the majority of the cases, a distal inclination toward the ramus.LimitationsA larger sample size is mandatory to assess the frequencies and treatment modalities.ConclusionThe presence of germs in the lower second permanent molars in patients with hidrotic ED is an important clinical symptom that should be monitored to detect and prevent ectopic migration of these teeth.Clinical significanceIn hidrotic ED cases, the study of the presence of the second lower permanent germs must include clinical and radiological examinations. Establishing an interceptive treatment is necessary to prevent the migration of the molars in question.How to cite this articleSfeir E, Aboujaoude S. Impacted Lower Second Permanent Molars at the Ramus and Coronoid Process: A New Clinical Symptom of the WNT10A Mutation in Ectodermal Dysplasia. Int J Clin Pediatr Dent 2017;10(4):363-368.
Evaluation of Knowledge, Awareness, and Occurrence of Dental Injuries in Participant Children during Sports in New Delhi: A Pilot Study
Authors: Kumar Puneet 
Published: December 2017

ABSTRACTAimTo evaluate the occurrence of dental injuries in children, the level of knowledge of the participants about preventive measures, and management of dental trauma during sports, in New Delhi.Materials and methodsA cross-sectional study was carried out among 450 children aged 6 to 16 years. A structured interviewer-guided questionnaire was used to determine the prevalence of oral injuries sustained during sport activities, the use of mouthguard as well as the athlete's awareness regarding use of mouthguard. The respondents consisted of 313 males (69.6%) and 137 females (30.4%) with a mean age of 12.6 years.ResultsOut of the total participants, 27 (6%) had chipping or fracture of teeth, 25 (5.6%) had soft-tissue laceration, 24 (5.4%) had avulsion of teeth, and 18 (4%) had suffered fracture of jaw/bones. Out of the total participants, 263 (58.4%) knew that it was possible to replant the teeth and 187 (41.6%) did not know that it was possible to replant the teeth. Out of the total participants, 203 (45.1%) did not know what is the best time to put the teeth back in the mouth and 247 (54.9 %) answered in affirmative with variable answer. Of the total participants, 223 (49.6%) answered that they would carry avulsed tooth in water, 94 (20.8%) wrapped in cloth, 57 (12.6%) in mouth/saliva, 9 (2%) in Hanks' balanced salt solution (HBSS), and 67 (14.8%) answered others. Of the total participants, 321 (71.3%) were aware that mouthguards prevent injury and 129 (28.7%) did not know about mouthguards. Out of the total participants, 94 (20.9%) used mouthguards and 356 (79.1%) had never used mouthguards.ConclusionLevel of awareness and knowledge about sports-related orofacial injury is very poor among children in New Delhi. Education on prevention of orofacial trauma should be given to the coaches and children. Wearing of mouthguards during sport activities should be compulsory during practice and competition events.How to cite this articleGoswami M, Kumar P, Bhushan U. Evaluation of Knowledge, Awareness, and Occurrence of Dental Injuries in Participant Children during Sports in New Delhi: A Pilot Study. Int J Clin Pediatr Dent 2017;10(4):373-378.
Management of Mandibular Angle Fracture in a 9-year-old with Miniplate and Monocortical Screws: A Clinical Challenge
Authors: Shunmugavelu Karthik , Subramaniam Kumaravel 
Published: December 2017

ABSTRACT
The main characteristic feature of the pediatric mandible is that of decreased dimension, which leads to compromises in the open reduction and internal fixation (ORIF). In the dental segment, the cervically bulbous short stature primary teeth might act an obstacle during the maxillomandibular fixation conventionally. An increased osteogenic potential of bones favors rapid consolidation and remodeling in the affected region. The mixed dentition of the ugly duckling stage adds more burden while stabilizing the fractured segments. The main goal of the clinician is to achieve and restore the facial appearance and function. Hereby, we present a clinical challenge depicting a 9-year-old male with mandibular angle fracture managed by miniplate and monocortical screws fixation.

How to cite this article
Shunmugavelu K, Subramaniam K. Management of Mandibular Angle Fracture in a 9-year-old with Miniplate and Monocortical Screws: A Clinical Challenge. Int J Clin Pediatr Dent 2017;10(4):391-393.
Reviewer Acknowledgements for International Journal of Statistics and Probability, Vol. 7, No. 1
Authors: Smith Wendy 
Published: December 2017

International Journal of Statistics and Probability wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated.Many authors, regardless of whether International Journal of Statistics and Probability publishes their work, appreciate the helpful feedback provided by the reviewers.Reviewers for Volume 7, Number 1 Afsin Sahin, Gazi University, TurkeyAli Reza Fotouhi, University of the Fraser Valley, CanadaBibi Abdelouahab, University Mentouri Constantine, AlgeriaFelix Almendra-Arao, UPIITA del Instituto Politécnico Nacional , MéxicoLuiz Ricardo Nakamura, University of Sao Paulo, BrazilMaryam Eskandarzadeh, Persion Gulf Boshehr University, IranShatrunjai Pratap Singh, John Hancock Financial Services, USAVilda Purutcuoglu, Middle East Technical University (METU), Turkey Wendy SmithOn behalf of,The Editorial Board of International Journal of Statistics and ProbabilityCanadian Center of Science and Education
Retrieval of Compositional End‐Members From Mars Exploration Rover Opportunity Observations in a Soil‐Filled Fracture in Marathon Valley, Endeavour Crater Rim
Authors: Stein N. T. , Arvidson R. E. , O'Sullivan J. A. , Catalano J. G. , Guinness E. A. , Politte D. V. , Gellert R. , VanBommel S. J. 
Published: December 2017

AbstractThe Opportunity rover investigated a gentle swale on the rim of Endeavour crater called Marathon Valley where a series of bright planar outcrops are cut into polygons by fractures. A wheel scuff performed on one of the soil‐filled fracture zones revealed the presence of three end‐members identified on the basis of Pancam multispectral imaging observations covering ~0.4 to 1 μm: red and dark pebbles, and a bright soil clod. Multiple overlapping Alpha Particle X‐ray Spectrometer (APXS) measurements were collected on three targets within the scuff zone. The field of view of each APXS measurement contained various proportions of the Pancam‐based end‐members. Application of a log maximum likelihood method for retrieving the composition of the end‐members using the 10 APXS measurements shows that the dark pebble end‐member is compositionally similar to average Mars soil, with slightly elevated S and Fe. In contrast, the red pebble end‐member exhibits enrichments in Al and Si and is depleted in Fe and Mg relative to average Mars soil. The soil clod end‐member is enriched in Mg, S, and Ni. Thermodynamic modeling of the soil clod end‐member composition indicates a dominance of sulfate minerals. We hypothesize that acidic fluids in fractures leached and oxidized the basaltic host rock, forming the red pebbles, and then evaporated to leave behind sulfate‐cemented soil.
The Electric Storm of November 1882
Authors: Love Jeffrey J. 
Published: December 2017

AbstractIn November 1882, an intense magnetic storm related to a large sunspot group caused widespread interference to telegraph and telephone systems and provided spectacular and unusual auroral displays. The (ring current) storm time disturbance index for this storm reached maximum −Dst ≈ 386 nT, comparable to Halloween storm of 29–31 October 2003, but from 17 to 20 November the aa midlatitude geomagnetic disturbance index averaged 214.25 nT, the highest 4 day level of disturbance since the beginning of aa index in 1868. This storm contributed to scientists' understanding of the reality of solar‐terrestrial interaction. Past occurrences of magnetic storms, like that of November 1882, can inform modern evaluations of the deleterious effects that a magnetic superstorm might have on technological systems of importance to society.
A Vesicular Stomatitis Virus‐Inspired DNA Nanocomplex for Ovarian Cancer Therapy
Authors: Zhao Wei , Yang Yuping , Song Lingling , Kang Tianyi , Du Ting , Wu Yujiao , Xiong Meimei , Luo Li , Long Jianlin , Men Ke , Zhang Lan , Chen Xiaoxin , Huang Meijuan , Gou Maling 
Published: December 2017

AbstractGene therapy provides a novel method for cancer therapy. This study shows a DNA nanocomplex that is inspired from vesicular stomatitis virus (VSV) for ovarian cancer therapy. This DNA nanocomplex consists of a cationized monomethoxy poly (ethylene glycol)‐poly (d,l‐lactide) (MPEG‐PLA) nanoparticle and a plasmid encoding the matrix protein of vesicular stomatitis virus (VSVMP) that plays a critical role in the VSV‐induced apoptosis of cancer cells. The cationized MPEG‐PLA nanoparticle that is self‐assembled by MPEG‐PLA copolymer and N‐[1‐(2,3‐dioleoyloxy) propyl]‐N,N,N‐trimethylammonium chloride (DOTAP) has low cytotoxicity and high transfection efficiency (>80%). Intraperitoneal administration of the pVSVMP nanocomplex remarkably inhibits the intraperitoneal metastasis of ovarian cancer and does not cause significant systemic toxicity. The apoptosis induction and anti‐angiogenesis are involved in the anticancer mechanism. This work demonstrates a VSV‐inspired DNA nanocomplex that has potential application for the treatment of intraperitoneal metastasis of ovarian cancer.
Crystal Imperfection Modulation Engineering for Functionalization of Wide Band Gap Semiconductor Radiation Detector
Authors: Ji Xu , Chen Liang , Xu Mengxuan , Dong Mei , Yan Kun , Cheng Shuang , Kong Xueqian , Wang Tongyao , Liu Jiandang , Gu Bingchuan , Wang Huanhua , Liu Zhiyong , Wang Shuao , Huang Feng , Ouyang Xiaoping 
Published: December 2017

AbstractControllable and repeatable crystal imperfection modulation engineering (CIME) is important for the development of semiconductor science and technology. However, for wide band gap semiconductors (WBGSs), there still lacks universal and reliable CIME. Here, based on the general idea of chemical composition complete expression design, a well‐designed, repeatable, and feasible CIME for ZnO is introduced, making free modulation of carrier in WBGS become possible. Briefly, this extraordinary CIME is dominated by two innovative procedures: an electrochemical doping and a strong oxidizing atmosphere annealing. The proposed CIME is a repeatable and universal carrier modulation project, which holds technological promise for various WBGS‐based semiconductor devices. Benefiting from this CIME, an α particle detector which operating at a high electric field of 107 V cm−1 can be fabricated successfully.
Semiconductor:Insulator Blends for Speed Enhancement in Organic Photodiodes
Authors: Strobel Noah , Eckstein Ralph , Lehr Jonathan , Lemmer Uli , Hernandez‐Sosa Gerardo 
Published: December 2017

AbstractOrganic photodiodes (OPDs) have been studied intensively for a number of years, as they enable low‐cost fabrication of sensor systems for imaging, medical, or industrial applications. While the device performance in terms of responsivity and detectivity is continuously improving, detection speed still lags behind. One of the major limiting factors is the large transit times of the charges. In this work, an approach of blending insulating polymers into a poly(3‐hexylthiophene‐2,5‐diyl) and [6,6]‐phenyl C61 butyric acid methyl ester bulk heterojunction system, which has already shown beneficial effects on the transport properties in organic field effect transistors or organic solar cells, is followed. Starting from a basic morphological study using poly(methyl methacrylate) (PMMA) with different molecular weights, both the steady‐state and dynamic characteristics of the OPDs are examined. Transient photocurrent measurements show that the inclusion of PMMA results in an increase of the −3 dB cut‐off frequency without adversely affecting the device steady‐state performance under illumination or in the dark. This increase is attributed to a reduced transit time in the active layer when PMMA is present.
Low Boiling Point Solvent Additives for Improved Photooxidative Stability in Organic Photovoltaics
Authors: Holliday Sarah , Luscombe Christine K. 
Published: December 2017

AbstractThe efficiency of organic photovoltaic (OPV) cells is rapidly increasing. However, many of the highest performance OPV devices are also the most unstable, including the two widely used benzodithiophene‐co‐thieno[3,4‐b]thiophene polymers, PTB7 and PTB7‐Th. Here it is shown that both the choice of pendant side chain, and solvents used for film deposition, have an important effect on active layer stability. Specifically, polymers with alkylthienyl side chains are found to be less stable than polymers with alkoxy side chains. Secondly, high boiling point solvent additives such as 1,8‐diiodooctane are found to dramatically accelerate photooxidation unless they are removed fully during device processing, which may be attributed to increased oxygen diffusion in films containing residual solvent. Replacing these higher boiling point solvent additives with lower boiling additives can greatly enhance the polymer stability without requiring high vacuum treatment, making these systems more scalable and compatible with roll‐to‐roll printing. Based on this finding, the non‐halogenated solvent system o‐xylene with 2% N‐methylpyrrolidone is explored as a route to achieving higher active layer stability, while maintaining the favorable, intermixed morphology achieved with higher boiling point, halogenated solvent additives. This result offers a promising way forward in the development of scalable, stable, and high‐efficiency organic solar cells.
Centrifugation‐free washing: A novel approach for removing immunoglobulin A from stored red blood cells
Authors: Vörös Eszter , Piety Nathaniel Z. , Strachan Briony C. , Lu Madeleine , Shevkoplyas Sergey S. 
Published: December 2017

AbstractWashed red blood cells (RBCs) are indicated for immunoglobulin A (IgA) deficient recipients. Centrifugation‐based cell processors commonly used by hospital blood banks cannot consistently reduce IgA below the recommended levels, hence double washing is frequently required. Here, we describe a prototype of a simple, portable, disposable system capable of washing stored RBCs without centrifugation, while reducing IgA below 0.05 mg/dL in a single run. Samples from RBC units (n = 8, leukoreduced, 4‐6 weeks storage duration) were diluted with normal saline to a hematocrit of 10%, and then washed using either the prototype washing system, or via conventional centrifugation. The efficiency of the two washing methods was quantified and compared by measuring several key in vitro quality metrics. The prototype of the washing system was able to process stored RBCs at a rate of 300 mL/hour, producing a suspension of washed RBCs with 43 ± 3% hematocrit and 86 ± 7% cell recovery. Overall, the two washing methods performed similarly for most measured parameters, lowering the concentration of free hemoglobin by >4‐fold and total free protein by >10‐fold. Importantly, the new washing system reduced the IgA level to 0.02 ± 0.01 mg/mL, a concentration 5‐fold lower than that produced by conventional centrifugation. This proof‐of‐concept study showed that centrifugation may be unnecessary for washing stored RBCs. A simple, disposable, centrifugation‐free washing system could be particularly useful in smaller medical facilities and resource limited settings that may lack access to centrifugation‐based cell processors.
Total Synthesis of (±)‐Phomoidride D
Authors: Leung Joyce C. , Bedermann Aaron A. , Njardarson Jón T. , Spiegel David A. , Murphy Graham K. , Hama Naoto , Twenter Barry M. , Dong Ping , Shirahata Tatsuya , McDonald Ivar M. , Inoue Munenori , Taniguchi Nobuaki , McMahon Travis C. , Schneider Christopher M. , Tao Nancy , Stoltz Brian M. , Wood John L. 
Published: December 2017

AbstractDescribed herein is a synthetic strategy for the total synthesis of (±)‐phomoidride D. This highly efficient and stereoselective approach provides rapid assembly of the carbocyclic core by way of a tandem phenolic oxidation/intramolecular Diels–Alder cycloaddition. A subsequent SmI2‐mediated cyclization cascade delivers an isotwistane intermediate poised for a Wharton fragmentation that unveils the requisite bicyclo[4.3.1]decene skeleton and sets the stage for synthesis completion.
Enzymatic Electrosynthesis of Alkanes by Bioelectrocatalytic Decarbonylation of Fatty Aldehydes
Authors: Abdellaoui Sofiene , Macazo Florika C. , Cai Rong , De Lacey Antonio L. , Pita Marcos , Minteer Shelley D. 
Published: December 2017

AbstractAn enzymatic electrosynthesis system was created by combining an aldehyde deformylating oxygenase (ADO) from cyanobacteria that catalyzes the decarbonylation of fatty aldehydes to alkanes and formic acid with an electrochemical interface. This system is able to produce a range of alkanes (octane to propane) from aldehydes and alcohols. The combination of this bioelectrochemical system with a hydrogenase bioanode yields a H2/heptanal enzymatic fuel cell (EFC) able to simultaneously generate electrical energy with a maximum current density of 25 μA cm−2 at 0.6 V and produce hexane with a faradaic efficiency of 24 %.
Utilization and Short‐Term Outcomes of Primary Total Hip and Knee Arthroplasty in the United States and Canada
Authors: Cram Peter , Landon Bruce E. , Matelski John , Ling Vicki , Stukel Therese A. , Paterson J. Michael , Gandhi Rajiv , Hawker Gillian A. , Ravi Bheeshma 
Published: December 2017

ObjectiveTotal knee arthroplasty (TKA) and total hip arthroplasty (THA) are common and effective surgical procedures. This study sought to compare utilization and short‐term outcomes of primary TKA and THA in adjacent regions of Canada and the United States.MethodsThe study was designed as a retrospective cohort study of patients who underwent primary TKA or THA, comparing administrative data from New York and Ontario in 2012–2013. Demographic features of the TKA and THA patients, per capita utilization rates, and short‐term outcomes were compared between the jurisdictions.ResultsA higher percentage of New York hospitals performed TKA compared to Ontario hospitals (75.7% versus 42.1%; P < 0.001), and the mean annual procedural volume for TKAs was lower in New York hospitals (mean 179 versus 327 in Ontario hospitals; P < 0.001). After direct standardization, utilization was significantly lower in New York compared to Ontario, both for TKA (16.1 TKAs versus 21.4 TKAs per 10,000 population per year; P < 0.001) and for THA (10.5 THAs versus 11.5 THAs per 10,000 population per year; P < 0.001). For those who underwent TKA, the length of stay in Ontario hospitals was significantly longer (mean 3.7 days versus 3.4 days in New York hospitals; P < 0.001). A smaller percentage of New York patients were discharged directly home (46.2% versus 90.9% of Ontario patients; P < 0.001), but 30‐day and 90‐day readmission rates were higher in New York compared to Ontario (30‐day rates, 4.6% versus 3.9% [P < 0.001]; 90‐day rates, 8.4% versus 6.7% [P < 0.001]). For the THA cohorts, the results with regard to length of stay, discharge disposition, and readmission rates were similar to those for TKA.ConclusionOntario has higher utilization of total joint arthroplasty than New York but has a smaller percentage of hospitals performing these procedures. Patients are more likely to be discharged home and less likely to be readmitted in Ontario. Our results suggest areas where each jurisdiction could improve.
Cytochrome cCatalyzes the Hydrogen Peroxide‐Assisted Oxidative Desulfuration of 2‐Thiouridines in Transfer RNAs
Authors: Sierant Małgorzata , Kulik Katarzyna , Sochacka Elzbieta , Szewczyk Rafal , Sobczak Milena , Nawrot Barbara 
Published: December 2017

AbstractThe 5‐substituted 2‐thiouridines (R5S2Us) present in the first (wobble) position of the anticodon of transfer RNAs (tRNAs) contribute to accuracy in reading mRNA codons and tuning protein synthesis. Previously, we showed that, under oxidative stress conditions in vitro, R5S2Us were sensitive to hydrogen peroxide (H2O2) and that their oxidative desulfuration produced 5‐substituted uridines (R5Us) and 4‐pyrimidinone nucleosides (R5H2Us) at a ratio that depended on the pH and an R5 substituent. Here, we demonstrate that the desulfuration of 2‐thiouridines, either alone or within an RNA/tRNA chain, is catalyzed by cytochrome c(cyt c). Its kinetics are similar to those of Fenton‐type catalytic 2‐thiouridine (S2U) desulfuration. Cyt c/H2O2‐ and FeII‐mediated reactions deliver predominantly 4‐pyrimidinone nucleoside (H2U)‐type products. The pathway of the cyt c/H2O2‐peroxidase‐mediated S2U→H2U transformation through uridine sulfenic (U‐SOH), sulfinic (U‐SO2H), and sulfonic (U‐SO3H) intermediates is confirmed by LC–MS. The cyt c/H2O2‐mediated oxidative damage of S2U‐tRNA may have biological relevance through alteration of the cellular functions of transfer RNA.
Iron(III) Amine Bis(phenolate) Complex Immobilized on Silica‐Coated Magnetic Nanoparticles: A Highly Efficient Catalyst for the Oxidation of Alcohols and Sulfides
Authors: Karimpour Touraj , Safaei Elham , Karimi Babak , Lee Yong‐Ill 
Published: December 2017

AbstractWe aimed to immobilize a complex of iron(III) amine bis(phenolate) on silica‐coated magnetic nanoparticles as a new magnetically recoverable catalyst (Fe3O4@SiO2‐APTES‐FeLGDC). Both the chemical nature and the structure of catalyst were confirmed by using field‐emission transmission electron microscopy, field‐emission scanning electron microscopy, FTIR spectroscopy, thermogravimetric analysis, vibrating sample magnetometry, X‐ray photoelectron spectroscopy, XRD, atomic absorption spectroscopy, and elemental analysis. This sustainable catalyst leads to the efficient oxidation of a wide range of alcohols and sulfides with excellent conversion and selectivity under a mild conditions to their corresponding oxidized products, acids (or ketones) and sulfoxides, respectively. Furthermore, the stability of the structure and morphology of our efficient recyclable system was investigated, and all of the data proved that the complex was anchored firmly to the magnetite nanoparticles.