bluuebunny/crossref_metadata_2025_split huggingface dataset:
The similar to RCD-one 1 protein SRO1 interacts with GPX3 and functions in plant tolerance of mercury stress
Authors: Zhao Xiaoliang , Gao Lijie , Jin Pingning , Cui Liusu 
Published: December 2017

Abstract
Heavy metals in the environment are one of the major limiting factors affecting plant growth and development. However, the mechanisms of the heavy metal-induced physiological processes remain to be fully dissected. Here, we explored that SRO1 can physically interact with Glutathione Peroxidase 3 (GPX3) in Arabidopsis. Under Hg treatment, similar to the sro1, the growth of the gpx3/sro1 was repressed more seriously and the number of true leaves was more reduced and etiolated than that of the wild type and gpx3 plants. The electrolyte leakage rates showed that cell membrane integrity in gpx3/sro1 was damaged more severely than in the wild type and gpx3 mutant. The Real-time PCR results have shown that the expression of the APX1 and CAT3 was reduced under mercury stress in the sro1 and sro1/gpx3. Our results suggested that the combination of the SRO1 and GPX3 may be contributed to plant response to mercury stress by regulating ROS intracellular oxidative homeostasis.
New Exact Traveling Wave Solutions of the Unstable Nonlinear Schrödinger Equations
Authors: Hosseini K. , Kumar D. , Kaplan M. , Bejarbaneh E. Yazdani 
Published: December 2017

Abstract

The present paper studies the unstable nonlinear Schrödinger equations, describing the time evolution of disturbances in marginally stable or unstable media. More precisely, the unstable nonlinear Schrödinger equation and its modified form are analytically solved using two efficient distinct techniques, known as the modified Kudraysov method and the sine-Gordon expansion approach. As a result, a wide range of new exact traveling wave solutions for the unstable nonlinear Schrödinger equation and its modified form are formally obtained.
Corn Ethanol and U.S. Biofuel Policy 10 Years Later: A Quantitative Assessment
Authors: Hochman Gal , Zilberman David 
Published: December 2017

AbstractWe conduct meta‐analyses of the estimated impacts of corn ethanol on food and fuel prices, as well as greenhouse gases, and analyze the implications for the balance of trade. The meta‐analyses suggest that corn ethanol has minor effects on greenhouse gas emissions and significant yet moderate effects on food and fuel prices. However, corn ethanol has a relatively significant impact on fuel security in terms of reductions in the import of oil to the U.S. and its overall effect on the U.S. balance of trade.
Prevalence of community health-promoting practices in Singapore
Authors: Kailasam Manimegalai , Hsann Yin Maw , Vankayalapati Priyanka , Yang Kok Soong 
Published: December 2017

Summary
Both living and working environments have a substantial influence on promoting healthy living habits. A holistic and accurate assessment of the community health-promoting practices is important to identify gaps and to make continuous, tangible improvements. The aim of the study is to assess the prevalence of the Singapore community health-promoting practices. The community health-promoting practices in all residential zones of an electoral constituency were assessed based on a composite health promotion scoring system comprising of 44 measurable elements under the 5 domains of community support and resources; healthy behaviours; chronic conditions; mental health; and common medical emergencies. An alphabetical grading system was used based on the score ranges: grade ‘A’ (75% and above), grade ‘B’ (60% to below 75%), grade ‘C’ (50% to below 60%) and grade ‘D’ (below 50%). The community health-promoting practices were graded ‘D’ with an overall average score of 41%. The constituency achieved grade ‘C’ (59%) for mental health domain and grade ‘B’ (72%) for common medical emergencies. The health-promoting practices for the other domains were graded ‘D’ (<50%) except for healthy behaviour (physical activity) sub-domain which achieved grade ‘B’ (65%). Significant gaps were identified in the community health-promoting practices. The residential zones may benefit from the scoring system to identify gaps and prioritize high-impact strategies to improve their health practices.
A new gas cooling model for semi-analytic galaxy formation models
Authors: Hou Jun , Lacey Cedric G , Frenk Carlos S 
Published: December 2017

AbstractSemi-analytic galaxy formation models are widely used to gain insight into the astrophysics of galaxy formation and in model testing, parameter space searching and mock catalogue building. In this work, we present a new model for gas cooling in haloes in semi-analytic models, which improves over previous cooling models in several ways. Our new treatment explicitly includes the evolution of the density profile of the hot gas driven by the growth of the dark matter halo and by the dynamical adjustment of the gaseous corona as gas cools down. The effect of the past cooling history on the current mass cooling rate is calculated more accurately, by doing an integral over the past history. The evolution of the hot gas angular momentum profile is explicitly followed, leading to a self-consistent and more detailed calculation of the angular momentum of the cooled down gas. This model predicts higher cooled down masses than the cooling models previously used in galform, closer to the predictions of the cooling models in l-galaxies and morgana, even though those models are formulated differently. It also predicts cooled down angular momenta that are higher than in previous galform cooling models, but generally lower than the predictions of l-galaxies and morgana. When used in a full galaxy formation model, this cooling model improves the predictions for early-type galaxy sizes in galform.
High-resolution repertoire analysis of Tfr and Tfh cells reveals unexpectedly high diversities indicating a bystander activation of follicular T cells
Authors: Ritvo Paul-Gydéon , Chaara Wahiba , El Soufi Karim , Bonnet Benjamin , Six Adrien , Mariotti-Ferrandiz Encarnita , Klatzmann David 
Published: December 2017

ABSTRACTT follicular helper (Tfh) and regulatory (Tfr) cells regulate B cell activation and ultimately antibody production. While concordant results show that Tfh cells are specific for the immunizing antigens, limited and even controversial results have been reported regarding the specificity of Tfr cells. Here we used high-throughput T cell receptor (TCR) sequencing to address this issue. We observed that although the Tfh- and Tfr-cell repertoires are less diverse than those of effector (Teff) and regulatory T (Treg) cells, they still represent thousands of clonotypes after immunization with a single antigen. T-cell receptor beta variable (TRBV) gene usage distinguishes both follicular T cells (Tfol) from non-Tfol cells, as well as helper (Teff and Tfh) vs. regulatory (Treg and Tfr) cells. Analysis of the sharing of clonotypes between samples revealed that a specific response to the immunizing antigen can only be detected in Tfh cells immunized with a non-self-antigen and Tfr cells immunized with a self-antigen. Finally, the Tfr TCR repertoire is more similar to that of Tregs than to that of Tfh or Teff cells. Altogether, our results highlight a bystander Tfol-cell activation during antigenic response in the germinal centres and support the Treg cell origin of Tfr cells.Significance StatementFollicular helper T (Tfh) cells promote high-affinity antibody production by B cells while follicular regulatory T (Tfr) cells represses it. The question of the specificity of follicular T (Tfol) cells is of utmost importance in the understanding of the antibody response specificity and our work is the first to analysed the global Tfol TCR repertoire in wild type mice. This allowed us not only to portray the overall global structure of these repertoires, but also to substantiate the fact that Tfr cells respond to self-antigen while Tfh cells respond to non self-antigen, a still controversial issue. Importantly, our work revealed an unexpected bystander activation of Tfol cells. We think and discuss that it has a general significance in immune responses and possibly immunopathologies.
Robust manipulation of the behavior ofDrosophila melanogasterby a fungal pathogen in the laboratory
Authors: Elya Carolyn , Lok Tin Ching , Spencer Quinn E. , McCausland Hayley , Martinez Ciera C. , Eisen Michael B. 
Published: December 2017

AbstractMany microbes induce striking behavioral changes in their animal hosts, but how they achieve this is poorly understood, especially at the molecular level. Mechanistic understanding has been largely constrained by the lack of a model system with advanced tools for molecular manipulation. We recently discovered a strain of the behavior-manipulating fungal pathogenEntomophthora muscaeinfecting wildDrosophila, and established methods to infectD. melanogasterin the lab. Lab-infected flies manifest the moribund behaviors characteristic ofE. muscaeinfection: hours before death, they climb upward, extend their proboscides and affix in place, then raise their wings, clearing a path for infectious spores to launch from their abdomens. We found thatE. muscaeinvades the fly nervous system, suggesting a direct means by which the fungus could induce behavioral changes. Given the vast molecular toolkit available forD. melanogaster, we believe this new system will enable rapid progress in understanding the mechanistic basis ofE. muscae’s behavioral manipulation in the fly.
mTORC1 activates PASK-Wdr5 signaling to epigenetically connect the nutrient status with myogenesis
Authors: Kikani Chintan K. , Wu Xiaoying , Fogarty Sarah , Kang Seong Anthony Woo , Dephoure Noah , Gygi Steve , Sabatini David , Rutter Jared 
Published: December 2017

SummaryIn the tissue microenvironment, stem cell functions are modulated by extrinsic signaling cues such as peptide hormones and dietary nutrients. These signaling cues maintain the balance between self-renewal and differentiation of its resident stem cells. The mechanistic Target of Rapamycin Complex 1 (mTORC1) is implicated to play an important role in regulating this balance, although its downstream effectors in stem cells have been elusive. We have recently shown that the PASK protein kinase phosphorylates Wdr5 to stimulate muscle stem cell differentiation by epigenetically activating the Myogenin promoter. Here, we show that the PASK-Wdr5 signaling pathway is a nutrient-sensitive downstream target of mTORC1 in muscle stem cells. We show that phosphorylation of PASK, and in turn of Wdr5, by mTORC1 is required for the activation of Myogenin transcription, exit from the self-renewal and induction of the myogenesis program. Thus, mTOR connects the diverse extrinsic signaling cues to a central epigenetic process to regulate the muscle stem cell fate between self-renewal and differentiation.
Client-centred clinical genetic diagnostics
Authors: Otter Maarten , Stumpel Constance , van Amelsvoort Therese 
Published: December 2017

Purpose
The purpose of this paper is to establish the value of clinical genetic diagnostics in the lives of people with an intellectual disability (ID), their families, and their primary and professional caregivers. It has been shown that psychologists are more likely to make use of the opportunities offered by clinical genetic diagnostics if they have seen the psychological benefits in their own practice. Moreover, this paper aims to promote the practice of informing people with ID, their families, and other caregivers regarding the current technological advances in genetic diagnostics, thereby allowing these patients to decide for themselves whether to utilise these opportunities.

Design/methodology/approach
The authors report four case studies in which the psychosocial value to each patient is pivotal.

Findings
In these four cases, it is clear the medical model can augment the social model by providing an interpretation of its meaningfulness in the lives of the people concerned.

Research limitations/implications
Case studies alone can have limited scientific significance. This approach examining the significance of clinical genetic diagnosis should be studied further in larger groups.

Practical implications
It is hoped that psychologists and other professional caregivers will become enthused about the value of clinical genetic diagnostics and will choose to discuss the option of referral for clinical genetic diagnostics with their patients more often.

Social implications
People with an ID who are seeking mental health care, and their caregivers, should be given the opportunity to take part in the decision regarding whether to use clinical genetic diagnostics, which may even have a destigmatising effect.

Originality/value
Quality of life may improve for people with an ID seeking mental healthcare and for their caregivers as well by opening up discussion regarding the opportunities presented by clinical genetic diagnostics. The fact that people are able to make their own choices based on their own considerations can have a destigmatising effect.
Intellectual disabilities and ACT: feasibility of a photography-based values intervention
Authors: Boulton Natalie Elizabeth , Williams Jonathan , Jones Robert S.P. 
Published: December 2017

Purpose
There is limited evidence regarding clinical effectiveness of therapeutic interventions for people with intellectual disabilities (ID). Previous research has highlighted challenges regarding adaptation of Acceptance and Commitment Therapy (ACT) for people with ID. Central to ACT is a focus on living in congruence with individual core values. The concept of values is abstract and difficult for people with a limited verbal understanding to comprehend, and yet this approach holds much promise for people with ID. The paper aims to discuss these issues.

Design/methodology/approach
The current study outlines the adaptations undertaken to facilitate making the concept of values more accessible to people with ID. It also explores the feasibility of the adapted approach to the values component.

Findings
This trial has shown that it is possible to isolate a single component of ACT and adapt it for use with people with ID. The findings highlight the potential feasibility of a value-based approach for people with ID augmented through the use of participant-produced photography to enhance conceptual understanding of the values component of ACT.

Research limitations/implications
Findings were reliant on self-report data, which may result in inaccurate reporting and may be influenced by social demands. Given the diverse and unique presentations of people with ID, the inclusion and exclusion criteria limits the extent to which the current findings may be generalised to people with ID more widely.

Practical implications
Participant-produced photography may be directly applied to clinical practice, with implied benefits of improving access to, and meaningful engagement with psychological therapies for people with ID. Development of (and ability to articulate) a readily available and easily accessible values system, during times of adversity, represents a key implication arising from the current trial.

Originality/value
The current study shows that people with intellectual disability can be helped to appreciate abstract concepts such as personal core values. It also shows the potential to work through the medium of personal photography to explore the feasibility of the adapted approach to the values component – potentially a logical preliminary step towards an ACT-ID evidence base. To the authors’ knowledge, this novel approach is the first of its kind in the ID literature.
Simulation modeling for manpower planning in electrical maintenance service facility
Authors: Choudhari Sanjay , Gajjar Hasmukh 
Published: December 2017

Purpose
The purpose of this paper is to present the simulation model for manpower planning in electrical maintenance service facility and evaluates different scenarios to improve resource utilization while meeting the desired service level.

Design/methodology/approach
The process systematically maps entire system of electrical fault rectification, identifies probability distributions of demand of electrical maintenance requests and its process times using historical data. The simulation software Arena was used to model the entire system and various possible improvements were evaluated to assess performance of maintenance service facility.

Findings
The simulation results obtained for the proposed changes in the system indicated the potential improvement in resource utilization while meeting the average waiting time expectations of customers.

Practical implications
The proposed simulation model can help maintenance people to decide the optimum number of resources to meet the agreed performance level that is expected by various stakeholders.

Originality/value
The paper considers the computer simulation in modeling complex real-life system for understanding the resource requirement of electrical fault maintenance facility to improve resource utilization while meeting the desired service level.
Spreadsheets for business process management
Authors: van der Aalst Wil 
Published: December 2017

Purpose
Process mining provides a generic collection of techniques to turn event data into valuable insights, improvement ideas, predictions, and recommendations. This paper uses spreadsheets as a metaphor to introduce process mining as an essential tool for data scientists and business analysts. The purpose of this paper is to illustrate that process mining can do with events what spreadsheets can do with numbers.

Design/methodology/approach
The paper discusses the main concepts in both spreadsheets and process mining. Using a concrete data set as a running example, the different types of process mining are explained. Where spreadsheets work with numbers, process mining starts from event data with the aim to analyze processes.

Findings
Differences and commonalities between spreadsheets and process mining are described. Unlike process mining tools like ProM, spreadsheets programs cannot be used to discover processes, check compliance, analyze bottlenecks, animate event data, and provide operational process support. Pointers to existing process mining tools and their functionality are given.

Practical implications
Event logs and operational processes can be found everywhere and process mining techniques are not limited to specific application domains. Comparable to spreadsheet software widely used in finance, production, sales, education, and sports, process mining software can be used in a broad range of organizations.

Originality/value
The paper provides an original view on process mining by relating it to the spreadsheets. The value of spreadsheet-like technology tailored toward the analysis of behavior rather than numbers is illustrated by the over 20 commercial process mining tools available today and the growing adoption in a variety of application domains.
Do organisations have a mission for mapping processes?
Authors: Rowell James 
Published: December 2017

Purpose
The purpose of this paper is twofold: to identify and explore the reasons why organisations decide to use process mapping software (PMS) facilities in support of business process management (BPM); and to determine the objectives set by senior management for its introduction, and understand extent to which organisations achieve expected benefits.

Design/methodology/approach
This paper uses an exploratory research design and investigates the elements of organisations’ objectives, implementation and evaluation of using PMS. The research data were collected through semi-structured interviews with business managers responsible for the implementation of PMS. The respondent organisations were selected from a range of industries who were using the same software.

Findings
The results of the research show that organisations do set objectives for using PMS, relevant to a wide range of business, operational and strategic objectives, dependant on the needs of the organisation. Additionally, the results show that some gain further advantages post-implementation, based on their PMS experience. Regarding explicit evaluation of their investment, organisations attempt this to a very limited extent; whilst recognising a broad a range of “softer” benefits.

Research limitations/implications
This exploratory research has been conducted on a small range of organisations, all using the same software, therefore the results cannot be clearly generalizable. The research suggests organisations are making effective decisions regarding adopting PMS, further research on the evaluating its benefits could support better decision-making in the future.

Practical implications
The practical implications of this research are for decision-makers in organisations recognising and understanding the strategic/operational benefits that could be achieved by implementing a software system for BPM.

Originality/value
Whilst the use of process mapping of organisation’s operations is widespread the benefits achieved by organisations are only partially understood. Knowledge of the strategic impact of BPM is limited, as reported by numerous researchers. This research attempts to explore the context of organisations using such software, and point towards further approaches to its investigation.
Examining intention to adopt to internet of things in healthcare technology products
Authors: Karahoca Adem , Karahoca Dilek , Aksöz Merve 
Published: December 2017

PurposeThe purpose of the study is to investigate critical factors affecting individuals’ intention to adopt internet of things (IoT) products in healthcare.Design/methodology/approachAn integrated model was developed based on technology acceptance model (TAM), innovation diffusion theory (IDT), technological innovativeness (TI), protection motivation theory and privacy calculus theory. The model was tested with 426 respondents (222 females, 204 males) using partial least square structural equation model with all data grouped by gender.FindingsBased on the results of the complete model, perceived advantage (PA), image and perceived ease of use (PEOU) constructs have a significant effect on intention to adopt IoT healthcare technology products. The results show that for females, compatibility and trialability have more impact on PEOU whereas for males PA has more impact on PEOU. Image, perceived privacy risk, perceived vulnerability have more impact on males when compared to females.Research limitations/implicationsResearch conducted only among Turkish people.Originality/valueThis study investigated adoption of future technology, “internet of things”, products in healthcare from a behavioral perspective by integrating various theories. The reason is that before launching any technology into the market, its facilitative factors should be researched for the people who are going to use this in their daily routine.