bluuebunny/crossref_metadata_2025_split huggingface dataset:
LRP/LR Antibody Mediated Rescuing of Amyloid-β-Induced Cytotoxicity is Dependent on PrPc in Alzheimer’s Disease
Authors: Pinnock Emma C. , Jovanovic Katarina , Pinto Maxine G. , Ferreira Eloise , Dias Bianca Da Costa , Penny Clement , Knackmuss Stefan , Reusch Uwe , Little Melvyn , Schatzl Hermann M. , Weiss Stefan F.T. 
Published: December 2015

The neuronal perturbations in Alzheimer’s disease are attributed to the formation of extracellular amyloid-β (Aβ) neuritic plaques, composed predominantly of the neurotoxic Aβ42 isoform. Although the plaques have demonstrated a role in synaptic dysfunction, neuronal cytotoxicity has been attributed to soluble Aβ42 oligomers. The 37kDa/67kDa laminin receptor has been implicated in Aβ42 shedding and Aβ42-induced neuronal cytotoxicity, as well as internalization of this neurotoxic peptide. As the cellular prion protein binds to both LRP/LR and Aβ42, the mechanism underlying this cytotoxicity may be indirectly due to the PrPc-Aβ42 interaction with LRP/LR. The effects of this interaction were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assays. PrPc overexpression significantly enhanced Aβ42 cytotoxicity in vitro, while PrP–/– cells were more resistant to the cytotoxic effects of Aβ42 and exhibited significantly less cell death than PrPc expressing N2a cells. Although anti-LRP/LR specific antibody IgG1-iS18 significantly enhanced cell viability in both pSFV1-huPrP1-253 transfected and non-transfected cells treated with exogenous Aβ42, it failed to have any cell rescuing effect in PrP–/– HpL3-4 cells. These results suggest that LRP/LR plays a significant role in Aβ42-PrPc mediated cytotoxicity and that anti-LRP/LR specific antibodies may serve as potential therapeutic tools for Alzheimer’s disease.
Le travail social à l’épreuve du marché : l’émergence des entreprises intermédiaires à la fin des années 1970
Authors: Gérome Clément 
Published: December 2015

Cet article retrace la genèse du champ de l’insertion par l’activité économique (IAE), dont l’objet est la mise au travail de chômeurs « en difficulté » afin de permettre leur accès ultérieur à un emploi de droit commun. Il entend montrer dans quelle mesure la naissance du secteur de l’IAE à la fin des années 1970 constitue une rupture vis-à-vis des pratiques dominantes dans le champ du travail social. La mobilisation du concept d’épreuve permettra de rendre compte des logiques de justification et de légitimation des initiateurs des premiers dispositifs de l’IAE pour répondre aux critiques qui leur sont adressées et tenter d’institutionnaliser l’IAE parmi les politiques d’action sociale françaises.
Application of Grey Forecasting Model Based on Improved Residual Correction in the Cost Estimation of University Education
Authors: Ge Chao , Xie Jiaqi 
Published: December 2015

The forecast of the cost of education in university is conducive to strengthening the management of the cost of education, mining the potential of reducing the cost, improving the management level and improving the use efficiency of the funds. Through accounting and forecasting of the cost of education in university, we can make the school to plan the cost and quota index according to its own practical needs, so as to improve the financial system and cost management system of university education.
This will enable the university to carry out the correct decision-making, and provide support for the preparation of financial budget and long-term planning. At present, there are some defects in existing method of the university education cost prediction. The unitary regression method is very difficult to effectively remove the noise value in the fitting. Artificial neural network model is applied to predict the big data. Although the traditional gray forecasting model has a good prediction effect with the less data and poor information, the model still has the disadvantage that the background value is not smooth enough. In order to solve the above problems, this paper proposes an adaptive residual correction method based on grey system theory, and improves the grey forecasting model. This method can effectively remove the noise in the original data sequence, and it can be used to predict the cost of university education in China.
A Multi-task Combinatorial Optimization Model Based on Genetic Algorithm and its Application in College Education Curriculum Planning
Authors: Li Jianying , Zhou Zhe , Wang Liying 
Published: December 2015

Multi-task combinatorial optimization of a complex system is an important aspect of multi-task planning. To address the existing defects and limitations of the existing multi-task combinatorial optimization methods, the paper proposes a multi-task combinatorial model based on genetic algorithm. As a complex multi-task combinatorial optimization, the curriculum planning for higher education applies to itself the multi-task combinatorial model, which is based on genetic algorithm. Having fully considered such factors as teaching resources distribution, students’ intention and teachers’ intention, the paper designs a more efficient fitness function that has flexibly distributed courses and time in curriculum planning to meet the need of teaching in higher schools. Meanwhile, the paper utilizes specific cases of higher education to verify and analyze the algoritnm, and also carryies out a simulation test under the Matlab environment.
The result indicates that the multi-task combinatorial optimization model based on genetic algorithm can relatively significantly optimize curriculum planning of higher education.
Home Modifications for People With Alzheimer’s Disease: A Scoping Review
Authors: Struckmeyer Linda R. , Pickens Noralyn Davel 
Published: December 2015

Abstract
OBJECTIVE. The purpose of this review was twofold: (1) to gain insight into what is known from the literature about home modifications for people with Alzheimer’s disease (AD) and (2) to identify gaps in the literature that could lead to opportunities for research.
METHOD. A systematic scoping review of peer-reviewed articles published from 1994 through 2014 explored home modifications and AD.
RESULTS. Seventeen articles met the inclusion criteria. The three major findings pertain to (1) the caregiver role and caregiver training, (2) a client-centered collaborative approach to assessment and intervention, and (3) modifications for safety and function. Home modifications involved the physical and social environments as well as cognitive strategies at the task level.
CONCLUSION. Opportunities exist for the development of assessment procedures, the exploration of home modifications in the later stages of AD, and the study of home modification needs of people with dementia who live alone.
Contribution of Head Position, Standing Surface, and Vision to Postural Control in Community-Dwelling Older Adults
Authors: Pociask Fredrick D. , DiZazzo-Miller Rosanne , Goldberg Allon , Adamo Diane E. 
Published: December 2015

Abstract
Postural control requires the integration of sensorimotor information to maintain balance and to properly position and orient the body in response to external stimuli. Age-related declines in peripheral and central sensory and motor function contribute to postural instability and falls. This study investigated the contribution of head position, standing surface, and vision on postural sway in 26 community-dwelling older adults. Participants were asked to maintain a stable posture under conditions that varied standing surface, head position, and the availability of visual information. Significant main and interaction effects were found for all three factors. Findings from this study suggest that postural sway responses require the integration of available sources of sensory information. These results have important implications for fall risks in older adults and suggest that when standing with the head extended and eyes closed, older adults may place themselves at risk for postural disequilibrium and loss of balance.
Protective and Vulnerability Factors Contributing to Resilience in Post-9/11 Veterans With Service-Related Injuries in Postsecondary Education
Authors: Eakman Aaron M. , Schelly Catherine , Henry Kimberly L. 
Published: December 2015

Abstract
OBJECTIVE. To examine differences in psychosocial protective factors (social support, meaningful occupation, and academic self-efficacy) and health-related vulnerability factors (posttraumatic stress, depression, and somatic symptoms) contributing to resilience in post-9/11 veterans with service-related injuries and nonveterans in postsecondary education.
METHOD. A cross-sectional, matched-participants design using propensity score matching was used to test differences in mean levels of protective and vulnerability factors between injured veterans (n = 26) and nonveterans (n = 19); zero-order correlations explored relationships among study variables.
RESULTS. The veteran sample demonstrated lower levels of psychosocial protective factors and higher levels of health-related vulnerability factors compared with nonveterans (|0.49| to |1.56|). Psychosocial protective factors were consistently negatively associated with health-related vulnerability factors (−.27 to −.63).
CONCLUSION. Post-9/11 veterans with service-related injuries are at a substantial disadvantage in terms of resilience; lower protective factors and elevated vulnerability factors may increase their risk for poor campus integration and impede academic achievement.
Adult Attachment, Sensory Processing, and Distress in Healthy Adults
Authors: Meredith Pamela J. , Bailey Kirsty J. , Strong Jenny , Rappel Georgia 
Published: December 2015

Abstract
OBJECTIVE. To better understand the ways in which adult attachment, sensory processing, and distress may be interrelated in healthy adults.
METHOD. A cross-sectional study design was used with a convenience sample of 116 healthy participants who completed questionnaires before participating in a cold pressor pain-inducement task.
RESULTS. Attachment anxiety was significantly positively correlated with sensory sensitivity as measured using the Highly Sensitive Persons Scale and the Sensory Profile and with distress (i.e., stress, anxiety, and depression). Associations between attachment anxiety and both sensory sensitivity variables were lost when controlling for stress. Attachment avoidance was correlated only with sensory sensitivity measured using the Sensory Profile, and this relationship was retained when controlling for stress. Neither the attachment nor the stress variables were associated with sensation seeking.
CONCLUSION. Findings suggest that developing active coping approaches to deal with sensory sensitivities may be a valuable way to minimize distress. Recommendations for future research are provided.
Clinical Trial Registration: The Time Has Come
Authors: Chan Leighton , Heinemann Allen W. 
Published: December 2015

Abstract
Note from the AJOT Editor-in-Chief: AJOT has joined several other major rehabilitation and disability journals in a collaborative initiative to mandate clinical trial registration. Authors of manuscripts reporting clinical trials must ensure that the trials are registered before submitting their manuscript. For trials that are underway and are already enrolling patients, registration will be retrospective. This interim step achieves the goals of educating authors about trial registration and providing documentation of original study designs and primary outcome measures. Multiyear studies that were not registered before enrolling participants, are ongoing at the time of this editorial, and will not be completed before the January 1, 2017, deadline may be considered for publication in AJOT with special permission from the Editor-in-Chief. This permission must be obtained before submitting the manuscript for publication. By adopting these standards, we hope to further enhance the quality of AJOT articles.
This editorial is reprinted from the Archives of Physical Medicine and Rehabilitation, 96, 2093. http://dx.doi.org/10.1016/j.apmr.2015.09.005
Direct Epicardial Assist Device using Artificial Rubber Muscle in a Swine Model of Pediatric Dilated Cardiomyopathy
Authors: Saito Yoshiaki , Suzuki Yasuyuki , Kondo Norihiro , Kowatari Ryosuke , Daitoku Kazuyuki , Minakawa Masahito , Fukuda Ikuo 
Published: December 2015

Purpose Ventricular assist devices are a potent alternative or bridge therapy to heart transplants for dilated cardiomyopathy patients. However, ventricular assist devices have problems related to biocompatibility, hemocompatibility, and thromboembolic events, especially in younger patients. The present study examined the hemodynamic effects of a direct cardiac compression device using circumferential artificial rubber muscles in a young swine model of dilated cardiomyopathy. Methods Dilated cardiomyopathy was established in 6 pigs ( 6 – 8 weeks of rapid right ventricular pacing; average weight, 22.6 ± 2.1 kg). The device was designed using pneumatic rubber muscles (Fluidic Muscle, Festo). Hemodynamic parameters were monitored under baseline conditions, after the assistance, and after inducing ventricular fibrillation. Hemodynamic data were acquired using a PiCCO, multilumened thermodilution catheter in the pulmonary artery, left ventricular pressure monitoring, and epicardial echocardiography. Results Direct epicardial assistance resulted in a significant improvement in hemodynamic data. Cardiac output improved from 1.39 ± 0.24 L/min to 1.96 ± 0.46 (p = 0.02). Stroke volume (14.5 ± 3.2 mL versus 20.1 ± 4.3 ml, p<0.01) and ejection fraction (25.2 ± 3.6% versus 47.7 ± 7.8%, p<0.01) also improved after assistance. After inducing ventricular fibrillation, cardiac output was maintained at 1.33 ± 0.28 L/min. Conclusions Use of a circumferential direct epicardial assistant device resulted in improvement in hemodynamic data in a dilated cardiomyopathy model. Although there is still a need for improvements in device components, the direct cardiac assist device may be a good alternative to recent heart failure device therapies.
An Ethanol/Sodium Citrate Locking Solution Compared to Heparin to Prevent Hemodialysis Catheter-Related Infections: a Randomized Pilot Study
Authors: Vercaigne Lavern M. , Allan Don R. , Armstrong Sean W. , Zacharias James M. , Miller Lisa M. 
Published: December 2015

Purpose The objective of this study was to compare the initial safety and efficacy of a novel 30% ethanol/4% sodium citrate catheter-locking solution to heparin in a hemodialysis population. Methods This was a prospective, randomized, pilot study of 40 hemodialysis patients randomized to a 30% ethanol/4% sodium citrate or heparin 1000 units/mL locking solution. The primary outcome was identification of any serious adverse events over the study duration. Secondary outcomes included the rate per 1000 catheter days for catheter-related bloodstream infections (CRBSI), alteplase use, catheter dysfunction, and catheter removal. Results Three serious adverse events were reported as possibly related to the catheter solutions. Only one CRBSI was observed during the study in the heparin arm. The rate of alteplase use was 1.5/1000 catheter days in the heparin arm compared to 2.8/1000 catheter days in the ethanol/citrate arm (rate ratio = 1.85, 90% CI 0.48, 7.07, p value = 0.45), while the rate of catheter dysfunction was 6.8/1000 catheter days in the heparin arm compared to 1.9/1000 catheter days in the ethanol citrate arm (rate ratio = 0.27, 90% CI 0.10, 0.74, p value = 0.04). Catheter survival to first catheter outcome was longer in the ethanol/citrate group compared to heparin and there were no catheter removals due to bacteremia or thrombosis. Conclusions The ethanol/sodium citrate locking solution was safely used in this study. It appears to prevent CRBSI and may improve catheter survival compared to heparin. Trial registration ClinicalTrials.gov Identifier: NCT01394458.
Insertion of Peripheral Intravenous Cannulae in the Emergency Department: Factors Associated with First-time Insertion Success
Authors: Carr Peter J. , Rippey James C.R. , Budgeon Charley A. , Cooke Marie L. , Higgins Niall , Rickard Claire M. 
Published: December 2015

Background We sought to identify the reasons for peripheral intravenous cannulae insertion in the emergency department (ED), and the first-time insertion success rate, along with patient and clinician factors influencing this phenomenon. Methods A prospective cohort study of patients requiring peripheral cannulae insertion in a tertiary ED. Clinical and clinician data were obtained. Results A total 734 peripheral intravenous cannula (PIVC) insertions were included in the study where 460 insertions were analysed. The first-time insertion success incidence was 86%. The antecubital fossa (ACF) site accounted for over 50% of insertions. Multivariate logistic regression modelling to predict first-time insertion success for patient factors found: age <40 versus 80+ years, emaciated versus normal patient size, having a visible or palpable vein/s, and ACF versus forearm insertion site to be statistically significant. Statistically significant clinician factors predicting success were: higher number of prior cannulation procedures performed, and increased clinician perception of the likelihood of a successful insertion. When patient and clinician factors were combined in a logistic regression model, emaciated versus normal, visible vein/s, ACF versus forearm site, higher number of prior PIVC procedures performed and increased clinician perceived likelihood of success were statistically associated with first-time insertion success. Conclusions Peripheral intravenous cannulation insertion success could be improved if performed by clinicians with greater procedural experience and increased perception of the likelihood of success. Some patient factors predict cannulation success: ‘normal’ body weight, visible vein/s and cubital fossa placement; venepuncture may be a cheaper alternative for others if intravenous therapy is not imperative.
Formulas for Prediction of Insertion Depths of Internal Jugular Vein Catheters Adjusted to Body Height Categories
Authors: Struck Manuel F. , Schmidt Thomas , Winkler Bernd E. , Reinhart Konrad , Schummer Wolfram 
Published: December 2015

Purpose Whether formulas for prediction of central venous catheter (CVC) insertion depths have different applicability in patients with different body heights is not known. Goal of study was to test formulas for catheterizations of internal jugular veins (IJVs) in a population of different body height classes with correct CVC tip positions. Methods Consecutive adult patients requiring CVC for cardiac surgery were enrolled and those with tip positions at the junction of the superior vena cava and the right atrium ±1 cm underwent formula analysis. Precision of formula prediction was calculated for three classes of body height. Results Of the 635 included patients, 254 underwent right IJV catheterization and 381 underwent left IJV catheterization, respectively. Formula-guided approach for both right [formulas (height/10) (in cm) and (height/10) −1 (in cm)] and left [formula (height/10) + 4 (in cm)] IJV CVC was more precise in patients with a body height of 170-180 cm compared with patients with a body height <170 cm (who required deeper insertion than predicted by formula) and patients with a body height >180 cm (who required a more proximal insertion than predicted by formula). Conclusions Independent from body height classes, all formulas calculated a relatively low likelihood of atrial positions but high risks of proximal mal-positioning. Thus, considering inter-individual differences of vascular anatomy and for safety reasons, formulas cannot be recommended.
How Culture Shapes the Reading of Fairy Tales: A Cross-Cultural Approach
Authors: Zhang Yehong , Lauer Gerhard 
Published: December 2015

Abstract
A large body of research consistently found cultural differences in cognition between Westerners and East Asians. We undertook a study to explore whether culture-specific thinking models may influence how German and Chinese children understand fairy tales. By transferring the established theoretical framework of individualism versus collectivism from cultural psychology to literary studies, we hypothesize that readers in western Europe prefer an individualistic-oriented thinking model for character evaluation, adventurous attitude to plot development, as well as concrete time and spatial perception; by contrast, their counterparts in East Asia use social-oriented interpretation styles for character judgment, a self-restrained attitude towards plot development, and a symbolic time and spatial imagination. The method we used relies on questionnaires, item-based analysis and factor analysis to learn about the most salient dimensions for cross-cultural story comprehension. We found differences in all three dimensions of story comprehension, namely character evaluation, plot development, and time/space imagination. The results reveal how culture shapes the way we read and point to the important role of embedded schematic knowledge for story comprehension.
Systeemmishandeling: recht doen aan de zienswijzen van ouderen zelf
Authors: Lindenberg J. , Mysyuk Y. , Westendorp R.G.J. 
Published: December 2015

System abuse: doing justice to the views of the elderly
Two approaches have dominated the way elder abuse is explained and defined: the intrapersonal and interpersonal approaches. More recently, an environmental approach is emerging that takes into account contextual factors. This approach also meets the perspectives of older individuals themselves better. They describe how they feel abused or neglected by the system – by the way in which we organize our institutions. Institutions mirror our society and are shaped in interaction with societal norms and expectations. This influences the way in which older individuals are looked upon, are being approached, and how they see themselves within these institutions. This system abuse is currently beyond the scope of the most commonly used definitions and approaches of elder abuse. However, it is important to acknowledge system abuse, because it makes explicit how older individuals feel abused by and within our institutions. The distress and harm that they experience can therewith be acknowledged and prevented.
Ontspoorde zorg, gehechtheid en interactie
Authors: Royers T. 
Published: December 2015

Stress in caring, attachment behavior and interaction
Caring for someone can be very strainful. In this article the author states that stress reactions are not necessarily due to the burden of the emotional or practical care load itself. More important factors are the individual capability to regulate emotions and the way in which careseeker and caregiver interact on emotional topics such as pain, panic, sorrow, depression, and anger. The author starts from the attachment theory and describes the importance of attachment for someone who feels threatened, sick or fearful. Deep stress may hinder the caregiver to be aware of the thoughts, emotions and acts of the other person. Several effective and non-effective interaction patterns are described. The author argues that without self regulation the risk of care derailing and mistreatment will be substantial while the need for external regulation grows.
Het levenstestament
Authors: Engelbertink C.G.C. 
Published: December 2015

Mental incapacity and the power of attorney
A legal document appointing one or more people to help a person make decisions or to make decisions on the person’s behalf is a power of attorney (levenstestament). It is meant to be used in situations when illness prevents a person to make decisions that need to be made. In the levenstestament certain trusted people have been given the authority to manage money affairs, property and medical decisions on behalf of the ill person. The document is registered. The author argues that mental incapacity can also be temporarily or partially.