bluuebunny/crossref_metadata_2025_split huggingface dataset:
RGD peptide promotes follicle growth through integrins αvβ3/αvβ5 in three-dimensional culture
Authors: Matsushige Cassandra , Kitazumi Kaelyn , Beaman Amanda , Miyagi Marissa , Tallquist Michelle D , Yamazaki Yukiko 
Published: October 2024

In briefThree-dimensional ovarian tissue culture is a unique model to define the effects of molecules on folliculogenesis. Using this model, we determined that RGD–integrin interaction plays a role in antrum formation and theca cell differentiation.AbstractWe recently developed a three-dimensional (3D) ovarian tissue culture system supported by bacterial-derived dextran hydrogel. Arg-Gly-Asp (RGD) is an extracellular matrix-derived triple peptide. Immature ovarian tissues cultured in RGD-modified dextran hydrogel significantly promoted antral follicle growth and oocyte quality compared with those cultured in dextran hydrogel alone. In this study, we examined the mechanism of follicle growth stimulated by RGD treatment in the 3D system. First, we detected that direct contact between RGD-modified dextran hydrogel and ovarian interstitial cells is necessary to promote antral follicle growth. Therefore, we hypothesized that RGD stimulates antral follicle growth through RGD-binding integrin receptors expressed in the interstitial cell mass. Using quantitative PCR (qPCR) and immunochemical staining, we identified that integrins ⍺vβ3 and ⍺v5 are predominantly expressed in the ovarian interstitial compartment. To assess the effect of RGD–integrin interaction on follicle growth, ovarian tissues were cultured with cilengitide (Ci), an inhibitor specific for ⍺vβ3 and ⍺vβ5. Ci treatment suppressed RGD-induced follicle growth and oocyte quality in a dose-dependent manner. When the interstitial cell aggregates were cultured with RGD, cell migration and theca-related gene expression were significantly upregulated. Ci treatment dramatically suppressed these RGD-induced activities. In coculturing the interstitial aggregate and secondary follicles with RGD, migrating cells formed the outermost cell layers around the follicles, like theca layers, which were totally blocked by Ci treatment. In conclusion, our results suggest that RGD stimulates theca cell differentiation in the ovarian interstitial cells through integrins ⍺vβ3 and ⍺v5 to promote antral follicle growth in our 3D system.
ОЦЕНКИ РАЗБАЛАНСИРОВКИ ЗАГРУЗКИ ПРОЦЕССОРОВ ПРИ РАСПАРАЛЛЕЛИВАНИИ РЕШЕНИЯ 3D КРАЕВЫХ ЗАДАЧ НА КВАЗИСТРУКТУРИРОВАННЫХ СЕТКАХ
Authors: КЛИМОНОВ И.А. , КОРНЕЕВ В.Д. , СВЕШНИКОВ В.М. 
Published: October 2024

Проведены исследования влияния разбалансировки загрузки процессоров при распараллеливании решения 3D краевых задач на квазиструктурированных параллелепипедальных сетках. Получены оценки влияния разбалансировки на время решения задачи в зависимости от числа процессоров и числа узлов сетки. Даны результаты численных экспериментов, подтверждающие теоретические предпосылки.
A study of the influence of unbalancing the processor load in parallelization of solutions of 3D boundary value problems on quasi-structured parallelepiped grids is carried out. Estimates of the influence of the unbalance on the time of solving the problems depending on the number of processors and the number of grid nodes used are given. The results of numerical experiments confirm the theoretical conclusions.
ЧУВСТВИТЕЛЬНОСТЬ ФУНКЦИОНАЛОВ К ВХОДНЫМ ДАННЫМ В ЗАДАЧЕ ВАРИАЦИОННОГО УСВОЕНИЯ ДЛЯ МОДЕЛИ ТЕРМОДИНАМИКИ МОРЯ
Authors: ШУТЯЕВ В.П. , ПАРМУЗИН Е.И. 
Published: October 2024

Рассматривается задача вариационного усвоения данных наблюдений для модели термодинамики моря с целью восстановления потоков тепла на поверхности с учетом ковариационных матриц ошибок входных данных. Исследована чувствительность функционалов от решения к входным данным в рассматриваемой задаче вариационного усвоения и приведены результаты численных экспериментов для модели динамики Балтийского моря.
A problem of variational data assimilation for a sea thermodynamics model is considered, with the aim to reconstruct sea surface heat fluxes taking into account the covariance matrices of input data errors. The sensitivity of some solution functionals to input data in this problem of variational assimilation is studied, and the results of numerical experiments for a model of dynamics of the Baltic Sea are presented.
ЧИСЛЕННОЕ СТОХАСТИЧЕСКОЕ МОДЕЛИРОВАНИЕ ПРОСТРАНСТВЕННО НЕОДНОРОДНОЙ ПОПУЛЯЦИИ
Authors: ПЕРЦЕВ Н.В. , ТОПЧИЙ В.А. , ЛОГИНОВ К.К. 
Published: October 2024

Построена непрерывно-дискретная стохастическая модель, описывающая эволюцию пространственно неоднородной популяции. Структура популяции задается в терминах графа с двумя вершинами и двумя однонаправленными ребрами. Граф отражает пребывание индивидуумов популяции в вершинах и их переходы между вершинами по ребрам. Индивидуумы поступают в популяцию из внешнего источника в каждую из вершин графа. Длительности перемещения индивидуумов по ребрам графа постоянны. Индивидуумы могут погибать или превращаться в индивидуумов других популяций, не рассматриваемых в модели. Сформулированы предположения модели, приведены вероятностная формализация модели и алгоритм численного моделирования, основанный на методе Монте-Карло. Исследованы законы распределения численности популяций. Представлены результаты вычислительного эксперимента.
A continuous-discrete stochastic model is constructed to describe the evolution of a spatially heterogeneous population. The population structure is defined in terms of a graph with two vertices and two unidirectional edges. The graph describes the presence of individuals in the population at the vertices and their transitions between the vertices along the edges. Individuals enter the population from an external source at each of the vertices of the graph. The duration of movement of individuals along the edges of the graph is constant. Individuals may die or turn into individuals of other populations not considered in the model. The assumptions of the model are formulated, the probabilistic formalization of the model and the numerical simulation algorithm based on the Monte Carlo method are given. Distribution patterns of the population are studied. The results of a computational experiment are presented.
Analisis Semiotika Roland Barthes Pada Logo Nahdlatul Ulama’
Authors: Sholihah Musarrofatus , Zakarias Cecep 
Published: October 2024

Penelitian ini merupakan kajian semiotik yang mempelajari hakikat tentang keberadaan suatu tanda, dimana persepsi dan pandangan tentang realitas, dikonstruksikan oleh kata-kata dan tanda-tanda lain yang digunakan dalam konteks sosial. Tanda membentuk persepsi manusia, lebih dari sekedar merefleksikan realitas yang ada. Tradisi semiotika mencakup teori utama mengenai bagaimana tanda mewakili objek, ide, situasi, keadaan, perasaan, dan sebagainya yang berada diluar diri. Metode yang digunakkan dalam penelitian ini adalah studi kajian literatur mengenai tanda pada kajian semiotika. Dalam kehidupan sehari-hari manusia tidak dapat lepas dari tanda, lambang, maupun simbol-simbol. Tanda, lambang, dan simbol-simbol tersebut dapat kita jumpai diberbagai upacara tradisional yang diselenggarakan oleh masyarakat Jawa. Agar dapat memahami hal tersebut maka harus mengetahui ilmu yang mendukungnya. Adapun ilmu yang mempelajari tentang tanda, lambang, dan simbol-simbol adalah semiotik. Semiotik oleh Ferdinand de Saussure diartikan sebagai ilmu yang mempelajari peran tanda (sign) sebagai bagian dari kehidupan sosial. Lebih lanjut semiotik adalah ilmu yang mempelajari struktur, jenis, tipologi, serta relasi-relasi tanda dalam penggunannya di dalam masyarakat. Oleh sebab itu, semiotik mempelajari relasi diantara komponen-komponen tersebut dengan masyarakat penggunanya. Pendekatan semiotik merupakan sebuah pendekatan yang memiliki sistem sendiri, berupa sistem tanda. Tanda itu dalam sastra khususnya sastra tulis diberikan dalam suatu bentuk teks, baik yang terdapat di dalam struktur teks maupun di luar struktur teks karya tersebut. Bisa dikatakan, melalui teori Roland Barthes dengan tanda denotasi, konotasi dan mitos, peneliti dapat lebih memahami makna atau simbol yang terkandung dalam dialog yang sehari-hari masyarakat gunakan. Penelitian ini menggunakan metode kualitatif dengan analisis semiotika dari Roland Barthes. Tujuan dari penelitian ini adalah untuk menganalisis makna denotative, konotatif, serta mitos dan ideologi dalam logo Nahdlaatul Ulama’.
Ragam Corak Tafsir: Tafsir Sufi
Authors: Abdillah Ihsan , Baihaqi Mochammad Rizky 
Published: October 2024

Karya-karya tafsir al-Qur’ân bercorak sufistik seperti halnya tasawuf sebagai disiplin ilmu, mendapat label plus-minus dari para pengkaji. Imam al-Thusiy mengomentari penafsiran sufi sebagai “Penafsiran seperti itu keliru (خطاء ) dan dusta (بهتان) kepada Allâh”. Imam al-Suyuthiy menyatakan bahwa pendapat para sufi dalam memaknai al-Qur’ân tidak dianggap sebagai tafsir. Ibn Shalah dalam Fatâwa-nya, Ia mengutip apa yang dikatakan oleh Imam Abi Hasan al-Wahidi; siapa yang menganggap bahwa kitab al-Sulami itu kitab tafsir maka ia telah menjadi kafir. Demikian juga penolakan dari Imam al-Zarkasyiy, Imam al-Nasafi dan Imam al-Rafi’iy. Sementara itu, banyak ulama yang memandang bahwa tafsir sufistik memiliki faidah untuk mengurai sisi esoterik al-Qur’ân dengan asumsi bahwa al-Qur’ân memiliki makna dzahir dan makna bathin. Jika demikian, maka tafsir sufistik memiliki kontribusi jelas pada pemaknaan dari aspek bathinnya dengan perangkat takwil atau isyarat-isyarat tertentu, sementara untuk makna zhâhir-nya sudah digarap oleh perangkat tafsir. Imam al-Ghazali menegaskan bahwa tidak ada larangan seseorang menafsirkan al-Qur’ân dengan penafsiran sufistik jika bermaksud untuk menampilkan kekayaan makna al-Qur’ân hingga batas-batas pemaknaan dengan simbol atau isyarat-isyarat tertentu. Perdebatan tentang status tafsir sufistik antara kebolehan membaca, memahami dan mengamalkannya seperti yang representasikan oleh Imam al-Ghazali versus beberapa ulama yang menolak karya-karya tafsir sufistik, me-niscayakan untuk mendefinisikan tafsir sufistik dan memetakan (mapping) tafsir sufistik dengan membuat kategori-kategori baik paradigma, karya-karya, kelebihan-kelebihan dan kekurangan-kekurangannya.
Analisis Linguistik atas Relevansi Każib dalam Al-Qur’an dengan Prank di Media Sosial
Authors: Sa’dina Ahmad Midrar , Yunus Badruzzaman M. , Taufiq Wildan 
Published: October 2024

Każib adalah salah satu kata yang sering diulang-ulang dalam Al-Qur’an. Pengulangan kata każib dibagi menjadi derivasi dari dua belas każib dalam Al-Qur’an. Każib diletakkan sesuai dengan struktur kalimat dan makna yang terkandung di dalamnya. Sehingga penempatan derivasi każib dalam al-Qur’an sesuai dengan konteks pembahasan di dalamnya. Pembahasannya cenderung pada ranah sosial dan kepercayaan. Oleh karena itu, menarik untuk menganalisisnya dengan menerapkan analisis terstruktur. Tujuan dari penelitian ini adalah untuk mengetahui derivasi każib dalam Al-Qur’an dan menjelaskan struktur yang terkandung dalam derivasi każib dalam Al-Qur’an dengan menggunakan komparasi analisis struktural-Linguistik Ferdinand de Saussure dan Analisis Linguistik Toshihiko Izutsu. Penelitian ini menggunakan metode penelitian kepustakaan dan menggunakan pendekatan komparasi linguistik struktural yang dikemukakan oleh Ferdinand de Saussure dengan linguistik Toshihiko Izutsu yang terdiri dari 4 tahapan komparasi analisis yakni signifier -signified dan makna dasar, analisis langue-parole dengan makna relasional, sinkronik-diakronik dan sintagmatik-paradigmatik dengan Weltanschauung. Analisis data menggunakan model tematik yang melalui tahapan sebagai berikut: 1) mengumpulkan dan mengklasifikasikan data primer berupa ayat-ayat Al-Qur’an yang mengandung turunan każib, 2) memfokuskan pada data yang layak untuk dianalisis, 3) menyajikan hasil penelitian. Data berupa deskripsi naratif pendek. Hasil penelitian ini bahwa prank yang kerap terjadi di media sosial merupakan gambaran struktur każib yang telah lama dideskripsikan al-Quran melalui ayat-ayatnya. Egosentris dan penyamarataan jokes dengan dibungkus oleh asumsi viral menggeser nilai-nilai humanis sebagai manusia bermartabat yang saling menghormati. Hal ini mengindikasikan jika al-Qur’an terus dipelajari dan dipahami maka akan meningkatkan kualitas imam manusia bahwa al-Qur’an hadir sebagai petunjuk bagi umat manusia dan shahih fi kulli zaman wa makan.
Formation of a Methodology for Strategic Assessment of the Factors of the Internal Environment of the Restaurant Business Organization
Authors: Serikov Kirill , Anisimov Alexander 
Published: October 2024

The successful functioning of restaurant business organizations largely depends on the state of internal environmental factors. In this regard, it is very important to use a relevant methodology for assessing the internal environment, which ultimately allows us to formulate a successful development strategy. Thus, there is a need to improve the methodology for strategic assessment of factors in the internal environment of a restaurant business organization. The purpose of the study is to develop and test a methodology for strategic assessment of factors in the internal environment of a restaurant business organization. The following methods were used in the study: benchmarking, expert assessments, correlation analysis, SNW analysis, and GAP analysis. The novelty of the conducted research lies in the development of the theory and methodology of strategic analysis of the internal environment, which consist in developing a methodology for analyzing the internal environment adapted for restaurant business organizations. The result of the study is a methodology for strategic assessment of factors in the internal environment of a restaurant business organization, justified from a socio-economic point of view. The authors conclude that the introduction of a new methodology for assessing internal factors improves the quality of the analysis, and, ultimately, the effectiveness of the development strategy of the restaurant business organization.
Talar head replacement for treatment of Müller – Weiss syndrome: three clinical cases
Authors: Skrebtsov V. V. , Protsko V. G. , Skrebtsov A. V. , Tamoev S. K. 
Published: October 2024

Introduction Müller – Weiss syndrome is a rare condition that is characterized by avascular necrosis of the navicular bone leading to severe foot deformity, pain disturbing activities of daily living. There is no generally accepted treatment for avascular necrosis of the scaphoid, and the available treatments have disadvantages, which necessitates the need for new options.The objective was to present short-term results of three patients with osteonecrosis of the scaphoid and local necrosis of the talar head treated with ceramic talar head prosthesis, plastic surgery, metal osteosynthesis of the scaphoid and related surgical techniques.Material and methods Three patients diagnosed with Müller – Weiss syndrome were treated with ceramic talar head replacement, autologous bone grafting and metal osteosynthesis of the scaphoid bone with accompanying surgical techniques. Severity of pain and the condition of patients were assessed with the VAS and AOFAS AH scores.Results Short-term results showed consolidation at the site of metal osteosynthesis in all patients with no signs of instability of the talus hemiprosthesis. VAS and AOFAS AH scores indicated decrease in the pain and improved condition of the patients.Discussion Hemiarthroplasty of the talar head combined with plastic surgery and restoration of a congruent joint surface of the scaphoid, and associated surgical techniques may become an effective alternative to existing treatments for patients with Müller – Weiss syndrome, with further study.Conclusion The short-term findings showed that hemiarthroplasty was practical for restoration of the talonavicular mobility maintaining stable fixation of the talus.
Arthroplasty of the proximal interphalangeal joint of the hand: the current state of the problem
Authors: Fedotov P. V. , Kovalev D. V. , Mikhailov A. S. 
Published: October 2024

Introduction The proximal interphalangeal joint (PIP joint) plays an important role in ensuring optimal finger dexterity, grip strength and overall hand functionality. Arthroplasty is a promising direction in the surgical treatment of arthritis of the PIP joint of the hand, however, the inconsistency of the results encourages the world scientific community to be restrained and further investigate the problems associated with PIP joint arthroplasty.The purpose of the work was to identify the main problems of PIP joint arthroplasty based on the analysis of foreign and domestic medical literature.Materials and methods In this literature review, an analysis of foreign and domestic scientific publications devoted to the treatment of diseases and injuries of PIP joint was carried out. The purpose of the study was to provide a brief historical background and identify the main problems of PIP joint arthroplasty based on the analysis of foreign and domestic medical literature.Results and discussion The choice of the implant and the surgical aproach used are the two most frequently discussed issues in PIP joint arthroplasty; dorsal, palmar and lateral surgical approaches are described, each with its own advantages and disadvantages. Dorsal approaches are used most often because they are easier to perform; however, the fragile extensor apparatus is damaged with the subsequent development of extensor lag. A number of authors concluded that stiffness and extensor lag were the most common postoperative complications. Several combinations of materials are available: from classic chrome-cobalt/polyethylene to ceramic/ceramic and pyrocarbon/pyrocarbon. Most of them have not stood the test of time yet, and for most implants there is still a lack of real long-term monitoring series for survival of the design.Conclusion The morphology of joints, small bone sizes, complex biomechanics and the load on the hand are a special problem in PIP joint arthroplasty. It is still not possible to restore the full range of motion in this joint, despite the success of colleagues in arthroplasty of large joints.
Supporting preservice teachers to navigate the tensions of teaching English Language Arts: An examination of two teacher educator's literacies pedagogies
Authors: McKee Lori , Scheffel Tara-Lynn 
Published: October 2024

In 1997-1998, we taught in the same independently funded elementary school. As teachers of Grade 1 and Grade 2, the school leadership asked us to research and recommend a program to support early reading instruction and replace the outdated basal readers. Opinions were sometimes diverse as we met with parents and school board members to identify beliefs/priorities in early reading instruction. More than 25 years later, in our work as teacher educators in two provinces, we are embroiled in similar conversations about reading instruction in a field mapped by polarizing views expressed in reports, social media, and teacher professional texts. As teacher educators, we recognize: 1) this context as challenging for preservice teachers to enter professional practice and 2) our role in supporting preservice teachers in entering the field. This was the impetus for a research study examining our pedagogies. We ask: How are we, as teacher educators, supporting preservice teachers to navigate the theoretical and practical tensions of teaching Language Arts through our pedagogies?
In this article, we share findings from a collaborative Self-Study of Teacher Education Practice (S-STEP) where we leverage our long-standing relationship as critical friends in research/teaching to examine our teacher education pedagogies in our elementary English Language Arts courses in 2022-2023. Data sources include teaching artifacts (e.g., syllabi, powerpoints, activities) and videorecordings of discussions as we share these artifacts over Zoom. Guided by posthuman perspectives, we consider the non-human and human entities that were a part of our pedagogies. Analysis is currently underway. Preliminary findings suggest a shift from sharing particular practices with each other to a focus on decision-making to support preservice teachers in weighing the desires of teaching practices in literacies as well as diffusing binaries. This article highlights teacher education practices as relational and moving in response to context.
« Quelle est votre vision de la poésie? » : conceptions croisées de poètes québécois contemporains et d’enseignants du secondaire
Authors: Emery-Bruneau Judith , Alexandre Fednel 
Published: October 2024

Les auteurs de cet article visent à comprendre comment les conceptions de pratiques sociales de référence peuvent contribuer à reconfigurer un objet d’enseignement. Dans le cas présent, ils s’intéressent à l’objet « poésie ». Une analyse de contenu du discours de 32 poètes québécois contemporains confronté à celui de 20 enseignants du secondaire a été réalisée de façon à cerner les complémentarités et les distinctions dans leurs conceptions. Quelques aspects communs ont été identifiés à première vue : la poésie est associée à un travail sur la langue, à l’expression de soi, à des visions du monde représenté et à des dimensions de l’expérience esthétique. Toutefois, les justifications que donnent les uns et les autres pour décrire ces aspects diffèrent à plusieurs égards. Les résultats ouvrent la voie à une reconfiguration de la poésie en tant qu’objet d’enseignement. Ainsi, une transposition didactique de savoirs permettant de développer un rapport plus expérientiel et créatif à la poésie comme le défendent les poètes s’ajouterait à la dimension cognitive qui domine dans les conceptions des enseignants.
“What’s the Use?”: Undoing, Decolonizing, Liberating, and Righting Literacies Assessment in Turbulent Times
Authors: Honeyford Michelle , Watt Jennifer 
Published: October 2024

In this conceptual paper, we draw upon Ahmed (2019) and ask “what’s the use of assessment?” The Reimagining Literacies Assessment knowledge mobilization project contributes examples from research and pedagogy in classrooms with young children, in a Cree language immersion program, in anti-racist creative writing classrooms, and in research in reading instruction and assessment. Undoing, decolonizing, liberating, righting become concepts to think through the use of assessment and to propose critically urgent and emergent questions, practices, and possibilities for students and teachers.