bluuebunny/crossref_metadata_2025_split huggingface dataset:
PiMP my metabolome: an integrated, web-based tool for LC-MS metabolomics data
Authors: Gloaguen Yoann , Morton Fraser , Daly Rónán , Gurden Ross , Rogers Simon , Wandy Joe , Wilson David , Barrett Michael , Burgess Karl 
Published: August 2017

Abstract

Summary
The Polyomics integrated Metabolomics Pipeline (PiMP) fulfils an unmet need in metabolomics data analysis. PiMP offers automated and user-friendly analysis from mass spectrometry data acquisition to biological interpretation. Our key innovations are the Summary Page, which provides a simple overview of the experiment in the format of a scientific paper, containing the key findings of the experiment along with associated metadata; and the Metabolite Page, which provides a list of each metabolite accompanied by ‘evidence cards’, which provide a variety of criteria behind metabolite annotation including peak shapes, intensities in different sample groups and database information.

Availability and implementation
PiMP is available at http://polyomics.mvls.gla.ac.uk, and access is freely available on request. 50 GB of space is allocated for data storage, with unrestricted number of samples and analyses per user. Source code is available at https://github.com/RonanDaly/pimp and licensed under the GPL.

Supplementary information
Supplementary data are available at Bioinformatics online.
Morbidity and Mortality in Patients With Posterior Circulation Aneurysms Treated With the Pipeline Embolization Device: A Subgroup Analysis of the International Retrospective Study of the Pipeline Embolization Device
Authors: Lopes Demetrius K , Jang Dong-Kyu , Cekirge Saruhan , Fiorella David , Hanel Ricardo A , Kallmes David F , Levy Elad I , Lylyk Pedro 
Published: August 2017

Abstract

BACKGROUND
The safety of PipelineTM Embolization Device (PED; Medtronic Inc, Dublin, Ireland) in posterior circulation aneurysms is still controversial.

OBJECTIVE
To study complications associated with the treatment of posterior circulation aneurysms by conducting a subgroup analysis from the International Retrospective Study of PED registry.

METHODS
Data from 91 consecutive patients with 95 posterior circulation aneurysms at 17 centers between July 2008 to February 2013 were analyzed. The primary endpoint was defined as any complication leading to neurological morbidity or death. The outcome predictors were calculated using Kaplan–Meier and Cox regression methods.

RESULTS
The mean aneurysm size was 13.8 mm. Aneurysm types were saccular (36.8%), fusiform (29.5%), dissecting (28.4%), and others (5.3%). The median follow-up was 21.1 mo. Twelve (13.2%) patients encountered a primary endpoint event. In multivariate analysis for the primary endpoint, use of ≥3 PEDs and fusiform shape compared with other shapes had hazard ratios (HRs) of 7.77 (95% confidence interval [CI], 2.48-25.86; P = .0007) and 3.48 (95% CI, 1.06-13.39; P = .0488), respectively. The multivariate HR of aneurysm size for neurological morbidity after PED implantation was 1.11 (95% CI, 1.04-1.18; P = .0015), and HRs of ruptured aneurysm and age for neurological mortality were 8.1 (95% CI, 1.31-41.26; P = .0197) and 1.07 (95% CI, 1.02-1.15; P = .0262), respectively. Basilar artery aneurysm had an HR of 3.54 (95% CI, 1.12-14.18, P = .0529) in the univariate analysis for major outcomes.

CONCLUSION
PED implantation may be considered for the treatment of posterior circulation aneurysms, especially of saccular or dissecting type. Our major complications appear to be comparable to those reported previously after clipping and coiling in the literature. Neurointerventionists should consider the shape, size, rupture, and location of complex posterior circulation aneurysms as well as age and PED number before the PED placement.
Paratendinous Scraping and Excision of Plantaris for Achilles Tendinopathy
Authors: Jowett Charlie R.J. , Richmond Anneka , Bedi Harvinder S. 
Published: August 2017

Abstract:
Recent research has suggested a combined role of the plantaris tendon and neovascularization for Achilles tendinopathy recalcitrant to nonoperative management. The aim of our study was to determine if addressing both these issues improved symptoms of Achilles tendinopathy. We report on the results of a prospective case series involving 2 cohorts of patients between February 2011 and February 2015 undergoing this combined technique. One cohort included recreational athletes (group A), the second included patients who undertook minimal recreational activity (group B). In group A there were 19 patients (25 tendons). The mean age at surgery was 44 years (range, 20 to 55 y). The mean follow-up was 21 months (range, 7 to 38 mo). Patients were satisfied with the results in 21 of the 25 tendons (84%). The mean Victorian Institute of Sports Assessment-Achilles improved from 51 to 90 following surgery (P<0.001). One case was revised. In group B there were 7 patients (9 tendons). Patients were satisfied in 7 of the 9 cases. These results support the use of this combined procedure in recreational athletes with failed nonoperative management. We believe surgery provides a healthier environment for conservative load-based rehabilitation. In the nonathletic population results are less consistent.

Level of Evidence:
Diagnostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Rapid detection of bacterial meningitis using a point-of-care glucometer
Authors: Rousseau Geoffroy , Asmolov Romain , Grammatico-Guillon Leslie , Auvet Adrien , Laribi Said , Garot Denis , Jouan Youenn , Dequin Pierre-François , Guillon Antoine 
Published: August 2017

Background
In case of acute bacterial meningitis, a decision on the need for intensive care admission should be made within the first hour. The aim of this study was to assess the ability of a point-of-care glucometer to determine abnormal cerebrospinal fluid (CSF) glucose concentration at the bedside that contributes toward bacterial meningitis diagnosis.

Methods
We carried out a prospective study and simultaneously measured the glucose concentrations in CSF and blood using a central laboratory and a point-of-care glucometer. We compared CSF/blood glucose ratios obtained at the bedside with a glucometer versus those obtained by the central laboratory. We determined the performance characteristics of the CSF/blood glucose ratio provided by a glucometer to detect bacterial infection in the CSF immediately after CSF sampling.

Results
We screened 201 CSF collection procedures during the study period and included 172 samples for analysis. Acute bacterial meningitis was diagnosed in 17/172 (9.9%) of CSF samples. The median turnaround time for a point-of-care glucometer analysis was 5 (interquartile range 2–10) min versus 112 (interquartile range 86–154) min for the central laboratory (P<0.0001). The optimal cut-off of the CSF/blood glucose ratio calculated from a bedside glucometer was 0.46, with a sensitivity of 94.1% (95% confidence interval: 71.3–99.9%), a specificity of 91% (95% confidence interval: 85.3–95%), and a positive likelihood ratio of 10.

Conclusion
A glucometer accurately detects an abnormal CSF/blood glucose ratio immediately after the lumbar puncture. This cheap point-of-care method has the potential to speed up the diagnostic process of patients with bacterial meningitis.
Will Veterans Answer Sexual Orientation and Gender Identity Questions?
Authors: Ruben Mollie A. , Blosnich John R. , Dichter Melissa E. , Luscri Lorry , Shipherd Jillian C. 
Published: August 2017

Background:
The Veterans Health Administration does not routinely collect and document sexual orientation and gender identity (SOGI) data, despite existing health disparities among sexual and gender minority Veterans. Because of the legacy of previous Department of Defense (DoD) policies that prohibited disclosure of sexual or gender minority identities among active duty personnel, Veterans may be reluctant to respond to SOGI questions.

Objectives:
This population-based study assesses item nonresponse to SOGI questions by Veteran status.

Research Design:
This is a secondary analysis of data from a population-based sample of adults in 20 US states that elected to administer a SOGI module in the 2014 Behavioral Risk Factor Surveillance System survey. Prevalence of SOGI refusals and responses of “don’t know” were compared for Veterans and non-Veterans.

Subjects:
Veterans (n=22,587) and non-Veterans (n=146,475) were surveyed.

Results:
Nearly all Veteran respondents (≥98%) completed the SOGI questions, with 95.4% identifying as heterosexual, 1.2% as gay or lesbian, 1.2% as bisexual, and 0.59% as transgender. A significantly lower proportion of Veterans than non-Veterans refuse to answer sexual orientation (1.5% vs. 1.9%). There was no difference between Veterans and non-Veterans in responses for gender identity.

Conclusions:
Veterans are just as likely as non-Veterans to complete SOGI items in survey research. Asking Veterans about SOGI is unlikely to yield significant nonresponse. These data suggest that future research should investigate Veterans’ perspectives on being asked about SOGI in research settings and as part of routine clinical care.
Harnessing Implementation Science to Increase the Impact of Health Equity Research
Authors: Chinman Matthew , Woodward Eva N. , Curran Geoffrey M. , Hausmann Leslie R.M. 
Published: August 2017

Background:
Health disparities are differences in health or health care between groups based on social, economic, and/or environmental disadvantage. Disparity research often follows 3 steps: detecting (phase 1), understanding (phase 2), and reducing (phase 3), disparities. Although disparities have narrowed over time, many remain.

Objectives:
We argue that implementation science could enhance disparities research by broadening the scope of phase 2 studies and offering rigorous methods to test disparity-reducing implementation strategies in phase 3 studies.

Methods:
We briefly review the focus of phase 2 and phase 3 disparities research. We then provide a decision tree and case examples to illustrate how implementation science frameworks and research designs could further enhance disparity research.

Results:
Most health disparities research emphasizes patient and provider factors as predominant mechanisms underlying disparities. Applying implementation science frameworks like the Consolidated Framework for Implementation Research could help disparities research widen its scope in phase 2 studies and, in turn, develop broader disparities-reducing implementation strategies in phase 3 studies. Many phase 3 studies of disparity-reducing implementation strategies are similar to case studies, whose designs are not able to fully test causality. Implementation science research designs offer rigorous methods that could accelerate the pace at which equity is achieved in real-world practice.

Conclusions:
Disparities can be considered a “special case” of implementation challenges—when evidence-based clinical interventions are delivered to, and received by, vulnerable populations at lower rates. Bringing together health disparities research and implementation science could advance equity more than either could achieve on their own.
Exploring the Role of Key Workers in Cancer Care
Authors: Ling Jonathan , McCabe Karen , Brent Sue , Crosland Ann , Brierley-Jones Lyn 
Published: August 2017

Purpose/Aims:
The key worker role in cancer services was established in England to improve the continuity of care for patients. We examined how the role has been implemented by clinical nurse specialists and how both cancer patients and nursing staff viewed its effectiveness to inform debate about the transfer of patients between clinical nurse specialists during cancer care.

Design:
This study was questionnaire based, with separate surveys developed for patients and staff.

Method:
The questionnaires explored issues including implementation of the key worker role, modifications to it, and where the role was felt to have most impact. The questionnaires were completed by 101 staff members and 46 patients. The data were analyzed descriptively.

Results:
Perspectives on the key worker role differed between nursing staff respondents and patient respondents. Overall, patient respondents were very positive, whereas staff respondents were less so. The following is a key difference related to patient handover: 71% of patient respondents wanted the same key worker throughout their treatment, but only 28% of staff respondents did. Staff respondents wanted more training to clarify the role.

Conclusion:
Continuity of care through an assigned key worker was highly valued by patients. Successful implementation could be better achieved through improved communication with both nursing staff and allied health professions. Where possible, cancer patients should be assigned a dedicated key worker at initial diagnosis.
Contraception After Surgical and Medical Abortion: A Review
Authors: Roe Andrea Hsu , Bartz Deborah 
Published: August 2017

Importance
To prevent subsequent unintended pregnancy, contraception should be initiated soon after surgical and medical abortion. Evidence regarding the safety of postabortion contraception, especially for long-acting reversible methods, has accumulated in recent years.

Objective
This review seeks to provide up-to-date recommendations about the provision and timing of contraception after surgical and medical abortion.

Evidence Acquisition
Recommendations are based on the US Medical Eligibility Criteria (MEC) or on the authors’ review of the current literature for topics that the MEC does not address.

Results
Contraceptive counseling at the time of abortion should be collaborative. All reversible contraceptive methods are safe to begin immediately after surgical abortion, barring concern for surgical complications or underlying medical contraindications. After medical abortion, the implant may be initiated immediately, combined hormonal contraception may be initiated shortly thereafter, and the intrauterine device may be placed once the abortion is complete. Further research is needed to determine the optimal timing of depot medroxyprogesterone acetate initiation after medical abortion.

Conclusions and Relevance
Abortion is an important opportunity for contraceptive counseling and provision. Clinic policies and insurance coverage should maximize access to all contraceptive methods, including long-acting reversible methods.

Target Audience
Obstetricians and gynecologists, family physicians.

Learning Objectives
After completing this activity, the learner should be better able to describe the importance of combining contraception and abortion provision; specify the contraceptive methods that can be safely offered on the same day as surgical and medical abortion; utilize the MEC to identify medical contraindications to contraceptive use; and recognize the public health benefits of the prompt initiation of long-acting reversible methods.
Optimizing Postsurgical Scars: A Systematic Review on Best Practices in Preventative Scar Management
Authors: Perez Justin L. , Rohrich Rod J. 
Published: August 2017

Background:
Scar management is critical for every plastic surgeon’s practice and, ultimately, the patient’s satisfaction with his or her aesthetic result. Despite the critical nature of this component of routine postoperative care, there has yet to be a comprehensive analysis of the available literature over the past decade to assess the best algorithmic approach to scar care. To this end, a systematic review of best practices in preventative scar management was conducted to elucidate the highest level of evidence available on this subject to date.

Methods:
A computerized MEDLINE search was performed for clinical studies addressing scar management. The resulting publications were screened randomized clinical trials that met the authors’ specified inclusion/exclusion criteria.

Results:
This systematic review was performed in May of 2016. The initial search for the Medical Subject Headings term “cicatrix” and modifiers “therapy, radiotherapy, surgery, drug therapy, prevention, and control” yielded 13,101 initial articles. Applying the authors’ inclusion/exclusion criteria resulted in 12 relevant articles. All included articles are randomized, controlled, clinical trials.

Conclusions:
Optimal scar care requires taking into account factors such as incisional tension, anatomical location, and Fitzpatrick skin type. The authors present a streamlined algorithm for scar prophylaxis based on contemporary level I and II evidence to guide clinical practice.
Alzheimer's Disease Caregivers' Health and Important Resources: Next Steps in Intervention Research
Authors: Ross Kharah M. , Carroll Judith E. 
Published: August 2017

ABSTRACT
In this issue of Psychosomatic Medicine, Mausbach and colleagues report that Alzheimer's disease caregivers who engage in more pleasant leisure activities had lower blood pressure for 5 years compared with those who engage in fewer leisure activities. This novel finding suggests that something as simple as taking more walks in the park or more time for reading books could protect the physical health of caregivers. In this editorial, we review possible mechanisms linking pleasant leisure activities with lower blood pressure in caregivers and discuss potential barriers that prevent caregivers from engaging in pleasant leisure activities. One possibility is that caregivers may not give themselves “permission” to take time away from caregiving, or feel guilty or selfish for doing so. Another impediment may be lack of outside assistance or support that would be needed to take time for leisure activities. Primary health care providers may play an important role in helping caregivers overcome these obstacles. In addition, public policy innovations are needed to meet the increasing societal demands on the psychological and medical consequences of caregiver burden.
Gummy Smile Correction Using Lingual Orthodontics and Augmented Corticotomy in Extremely Thin Alveolar Housing
Authors: Nahm Kyung-Yen , Shin Seung-Yun , Ahn Hyo-Won , Kim Seong-Hun , Nelson Gerald 
Published: August 2017

Background:
Tooth movement out of anatomic limitations was assisted by augmented corticotomy using deproteinized bovine bone mineral.

Methods:
Lip protrusion can be reduced by premolar extraction followed by retraction of the anterior teeth. Surgical intervention is appropriate when the alveolar bone housing of the anterior region is insufficient for the tooth movement. In this patient, corticotomy in upper palatal area and anterior segmented osteotomy in the mandible were performed. Anatomic limitation to the retraction was expanded by xenograft. An antero-posterior lingual appliance was used to bodily retract the upper anterior teeth. The gummy smile was resolved by intrusion of upper entire arch using 2 mid-palatal temporary skeletal anchorage devices.

Results:
New bone formation was observed on palatal side of upper anterior teeth. The teeth were moved into augmented area without fenestration or vitality loss. Lip protrusion was resolved, and the gummy smile was effectively improved.

Conclusions:
Orthodontic tooth movement beyond the limitation of the alveolar bone housing can be achieved with surgical assistance, which can be performed under local anesthesia. Without orthognathic surgery, the gummy smile can be reduced using an antero-posterior lingual retractor with mid-palatal skeletal anchorage.
Formation of the Philtral Column Using a Dermal Graft in Secondary Unilateral Cleft Lip
Authors: Kim Jeenam , Park Jongok , Uhm Ki-il , Shin Donghyeok , Choi Hyungon 
Published: August 2017

Introduction:
The philtral column has an important aesthetic significance and is especially important in patients with cleft lip. If the integrity of the philtrum cannot be preserved in patients of unilateral clefts, these patients will have profound abnormalities in their facial musculature. The purpose of this study was to analyze the effects of dermal grafting on the philtral column in patients with a unilateral alveolar cleft.

Methods:
The authors retrospectively studied dermal grafts performed in Konkuk University Medical Center between January 2009 and January 2015. A total of 26 patients with unilateral cleft lip were included in this study; the authors measured philtral symmetry based on differences in convexity and angle using clinical photos. Additionally, panel evaluation was performed.

Results:
Of 26 patients enrolled, 21 completed follow-up and had adequate photographs. Five patients who were lost to follow-up were excluded. The difference in convexity decreased from 0.25 to 0.15 (P < 0.005) and the difference in angle decreased from 10.76 to 6.43 (P < 0.005). The panel evaluation indicated that patient appearances were significantly improved (P < 0.001).

Discussion:
In patients with secondary cleft lip deformity of the philtral depression, the authors’ procedure may augment the thickness of the philtral ridge and have positive aesthetic outcomes.
The Double Intravenous Catheter Technique for Single-Puncture Arthrocentesis
Authors: Nagori Shakil Ahmed , Chattopadhyay Probodh K. , Pathey Kamal K. , Dua Gaurav 
Published: August 2017

Abstract
Traditionally, arthrocentesis involves insertion of 2 needles into the joint space of which one acts as an inflow port and the other as the outflow port. These 2 needles must triangulate and be exactly placed in the upper joint space for the procedure to be effective. Due to the difficulty in maintaining the needle position, single-puncture arthrocentesis is gaining popularity. It is relatively easier to perform and less traumatic to the joint. The authors describe a simple technique of single-puncture arthrocentesis using parts of 2 peripheral intravenous catheters of different gauges. The outflow port is formed by the catheter tube of 1 cannula while the inflow port is formed by the needle of the second cannula. Besides beings easy to perform and cost-effective, our technique provides predictable joint lavage of the joint with minimal trauma to the tissues.
Pediatric Pseudotumor Cerebri Syndrome
Authors: Phillips Paul H. , Sheldon Claire A. 
Published: August 2017

Abstract:
Idiopathic intracranial hypertension, otherwise known as primary pseudotumor cerebri syndrome (PTCS), most frequently occurs in obese women of childbearing age. However, children may be affected as well. This review will address recent findings regarding demographics, diagnosis, and treatment of pediatric PTCS. Prepubertal children with primary PTCS have an equal sex distribution and less frequent obesity compared with adult patients. However, female gender and obesity are risk factors for primary PTCS in postpubertal children. Compared with adults, children with PTCS more frequently present with ocular motility deficits and more often have associated medical conditions that increase the risk of developing PTCS. Visual field testing may be unreliable, and the optimal modality to monitor visual function is unknown. MRI shows signs of elevated intracranial pressure (ICP) in children with PTCS similar to that of adults. It has now been established that elevated ICP in children ≤18 years old is greater than 25 cm H20 in nonobese, nonsedated children, and greater than 28 cm H2O in the remainder. Optical coherence tomography (OCT) may be used to distinguish pseudopapilledema from papilledema, monitor response to treatment in preverbal children, and identify patients with PTCS at risk for permanent visual loss. However, the precise role of OCT in the management of pediatric PTCS remains to be determined.