bluuebunny/crossref_metadata_2025_split huggingface dataset:
A QoS Control Scheme based on Software Defined Fiber-Wireless Access Network for Survivability
Authors: Ren Danping , Zhang Lijing , Zhao Jijun , Zhao Tianwei , Wu Shanshan 
Published: February 2017

Abstract
Fiber-Wireless (FiWi) access network is a promising broadband access network. Taking its heterogeneous structure into consideration, the paper introduces the Software Defined Networks (SDN) into FiWi access network. Survivability is an important issue in FiWi access network. Once there is a single fiber fails, many high-rate traffic flows may loss. A failure detection scheme is proposed for one distribution fiber fault in the new architecture. For the affected data flows recovery, we focus on the bandwidth allocation scheme for different priorities queues to meet the QoS. The simulation results show that the proposed scheme can maintain the QoS performance in terms of delay, loss rate and network throughput. The survivability is improved efficiently.
Serum proPSA as a marker for reducing repeated prostate biopsy numbers
Authors: Ayyıldız Sema Nur , Noyan Tevfik , Ayyıldız Ali , Benli Erdal , Çırakoğlu Abdullah , Ayyıldız Cemal 
Published: February 2017

Abstract

Introduction
Prostate specific antigen (PSA) has a lower sensitivity and specifity range of 4–10 ng/mL. We aimed to investigate the effectiveness of pPSA in reducing number of prostate biopsies.

Methods
This study enrolled 80 patients aged 50 years or older whom had serum total PSA levels between 4 ng/dL and 10 ng/dL. Age, prostate volume, tPSA, fPSA, pPSA, PSA%, pPSA%, t/pPSA, f/pPSA, p/fPSA, p/tPSA, f/p/tPSA, p/f/tPSA, PSAD, fPSA/PSAD, pPSA/PSAD, (Prostate Health Index) PHI, (t/f/pPSA)/tPSA, and PHI2 (New Prostate Health Index) biopsy results were compared between subjects BPH and PCa.

Results
Out of 80 subjects, 23 (29%) had PCa and 57 (71%) had BPH. Prostate volume was 51.65 mL in PCa and 64.85 mL in non-PCa group (p>0.05). The rate of PCa increased as prostate volume was reduced and age increased. fPSA, PSA%, p/f/tPSA, fPSA/PSAD values were significant in favor of respectively; BPH, BPH, PCa and BPH (p<0.05).

Discussion
Using prostate health index (PHI) was beneficial for predicting PCa. In addition, using pPSA in formulas such as (PHI2) pPSA/(fPSA*√tPSA), p/f/tPSA, (t/f/pPSA)/tPSA may also be useful. This study suggests that the use of pPSA may have a role in reducing the number of prostate biopsies in differentiating PCa and BPH.
NT-proBNP levels in β-thalassemia major patients without cardiac hemosiderosis
Authors: Kurtoğlu Ayşegül Uğur , Karakuş Volkan , Kurtoğlu Erdal , Bozkurt Selen 
Published: February 2017

Abstract

Introduction
Heart failure due to hemosiderosis is frequent in beta-thalassemia major (β-TM) patients. Magnetic resonance imaging (MRI) is used in the early detection of heart failure. Amino-terminal pro-brain natriuretic peptide (NT-proBNP) is a very sensitive marker in the diagnosis of heart failure. In this study, we aimed to investigate the efficacy of NT-proBNP levels in thalassemia patients, who are thought to have no cardiac iron deposition according to T2* scoring system (CMRT2*>20 msn), in early identification of cardiac failure.

Methods
NT-proBNP levels of 31 patients, who have T2*>20 ms, and of 25 healthy population were measured by chemoluminescence method.

Results
NT-proBNP levels were not different in thalassemic patients [median: 33 (IQR: 28–94) pg/mL] compared to control group [median: 41 (IQR: 28–59) pg/mL]. We found that NT-proBNP level was above cut-off value in six patients.

Conclusion
NT-proBNP is a cheaper, reachable, and noninvasive method compared to MRI technique, it can be easily used in monthly controls. Detection of high NT-proBNP levels above cut-off values in patients whose T2* values are normal indicates that measurement of NT-pro-BNP is a more sensitive marker in early detection of cardiac failure.
Ubiquitin Ligase RNF138 Promotes Episodic Ataxia Type 2-Associated Aberrant Degradation of Human Cav2.1 (P/Q-Type) Calcium Channels
Authors: Fu Ssu-Ju , Jeng Chung-Jiuan , Ma Chia-Hao , Peng Yi-Jheng , Lee Chi-Ming , Fang Ya-Ching , Lee Yi-Ching , Tang Sung-Chun , Hu Meng-Chun , Tang Chih-Yung 
Published: February 2017

Voltage-gated CaV2.1 channels comprise a pore-forming α1Asubunit with auxiliary α2δ and β subunits. CaV2.1 channels play an essential role in regulating synaptic signaling. Mutations in the human gene encoding the CaV2.1 subunit are associated with the cerebellar disease episodic ataxia type 2 (EA2). Several EA2-causing mutants exhibit impaired protein stability and exert dominant-negative suppression of CaV2.1 wild-type (WT) protein expression via aberrant proteasomal degradation. Here, we set out to delineate the protein degradation mechanism of human CaV2.1 subunit by identifying RNF138, an E3 ubiquitin ligase, as a novel CaV2.1-binding partner. In neurons, RNF138 and CaV2.1 coexist in the same protein complex and display notable subcellular colocalization at presynaptic and postsynaptic regions. Overexpression of RNF138 promotes polyubiquitination and accelerates protein turnover of CaV2.1. Disrupting endogenous RNF138 function with a mutant (RNF138-H36E) or shRNA infection significantly upregulates the CaV2.1 protein level and enhances CaV2.1 protein stability. Disrupting endogenous RNF138 function also effectively rescues the defective protein expression of EA2 mutants, as well as fully reversing EA2 mutant-induced excessive proteasomal degradation of CaV2.1 WT subunits. RNF138-H36E coexpression only partially restores the dominant-negative effect of EA2 mutants on CaV2.1 WT functional expression, which can be attributed to defective membrane trafficking of CaV2.1 WT in the presence of EA2 mutants. We propose that RNF138 plays a critical role in the homeostatic regulation of CaV2.1 protein level and functional expression and that RNF138 serves as the primary E3 ubiquitin ligase promoting EA2-associated aberrant degradation of human CaV2.1 subunits.SIGNIFICANCE STATEMENTLoss-of-function mutations in the human CaV2.1 subunit are linked to episodic ataxia type 2 (EA2), a dominantly inherited disease characterized by paroxysmal attacks of ataxia and nystagmus. EA2-causing mutants may exert dominant-negative effects on the CaV2.1 wild-type subunit via aberrant proteasomal degradation. The molecular nature of the CaV2.1 ubiquitin–proteasome degradation pathway is currently unknown. The present study reports the first identification of an E3 ubiquitin ligase for CaV2.1, RNF138. CaV2.1 protein stability is dynamically regulated by RNF138 and auxiliary α2δ and β subunits. We provide a proof of concept that protecting the human CaV2.1 subunit from excessive proteasomal degradation with specific interruption of endogenous RNF138 function may partially contribute to the future development of a novel therapeutic strategy for EA2 patients.
Safety of Second-Dose Single-Antigen Varicella Vaccine
Authors: Su John R. , Leroy Zanie , Lewis Paige W. , Haber Penina , Marin Mona , Leung Jessica , Woo Emily Jane , Shimabukuro Tom T. 
Published: February 2017

BACKGROUND AND OBJECTIVE:In 2006, routine 2-dose varicella vaccination for children was recommended to improve control of varicella. We assessed the safety of second-dose varicella vaccination.METHODS:We identified second-dose single-antigen varicella vaccine reports in the Vaccine Adverse Event Reporting System during 2006 to 2014 among children aged 4 to 18 years. We analyzed reports by age group (4–6 and 7–18 years), sex, serious or nonserious status, most common adverse events (AEs), and whether other vaccines were administered concomitantly with varicella vaccine. We reviewed serious reports of selected AEs and conducted empirical Bayesian data mining to detect disproportional reporting of AEs.RESULTS:We identified 14 641 Vaccine Adverse Event Reporting System reports after second-dose varicella vaccination, with 494 (3%) classified as serious. Among nonserious reports, injection site reactions were most common (48% of children aged 4–6 years, 38% of children aged 7–18 years). The most common AEs among serious reports were pyrexia (31%) for children aged 4 to 6 years and headache (28%) and vomiting (27%) for children aged 7 to 18 years. Serious reports of selected AEs included anaphylaxis (83), meningitis (5), encephalitis (16), cellulitis (52), varicella (6), herpes zoster (6), and deaths (7). One immunosuppressed adolescent was reported with vaccine-strain herpes zoster. Only previously known AEs were reported more frequently after second-dose varicella vaccination compared with other vaccines.CONCLUSIONS:We identified no new or unexpected safety concerns for second-dose varicella vaccination. Robust safety monitoring remains an important component of the national varicella vaccination program.
Expressões do português brasileiro com o verbo cair: uma abordagem semântico-pragmática para o ensino de língua adicional
Authors: Behle Nanashara Fagundes , Ibaños Ana Maria T. 
Published: February 2017

This study aims to present a way to help learners of Portuguese as an additional language to understand the meaning of expressions of Brazilian Portuguese, which need the context of the communicative process to have their meaning inferred. For this we adopted a semantic-pragmatic approach, with inferential bias proposed by the philosopher Paul Grice (1957, 1975) in his theories of conversation and of meaning. In this paper, we assume expressions of the verb cair because it is a frequent verb in Brazilian Portuguese everyday language, in expressions with a literal meaning and in idioms, assumed by Fernando (1996) as part of idiomaticity process. As a methodology we use Corpus Linguistics (Sardinha, 2004; O'keeffe; Carter; McCarthy, 2007) so we have access to authentic oral and written texts, using the corpus developed and maintained by Mark Davies and Michael J. Ferreira.
Three new species of Pleurothallis (Orchidaceae: Pleurothallidinae) in subsection Macrophyllae-Fasciculatae from northern South America
Authors: Wilson Mark , Baquero Luis , Dupree Katharine , Jiménez Marco M. , LeBlanc Cheryl M. , Merino Gilberto , Portilla Jose , Salas Guerrero Marcos , Tobar Suárez Francisco , Werner Jon D. 
Published: February 2017

The history of the taxonomy of Pleurothallis R.Br. subsection Macrophyllae-Fasciculatae and recent descriptions in that group are summarized. The phylogenetic position of the group based on preliminary molecular data and the appropriateness of the proposed genera Acronia C.Presl. and Zosterophyllanthos Szlach. & Marg. for this group are discussed. Three new species from northern South America are described: Pleurothallis rubrifolia from southeastern Ecuador and northeastern Peru; Pleurothallis nangaritzae from southeastern Ecuador; and Pleurothallis castanea. Labellar micromorphology examined by scanning electron microscopy for P. rubrifolia and P. nangaritzae is discussed in relation to taxonomy and possible pollinator interactions.
A TP53-mutáció-analízis jelentősége krónikus lymphocytás leukaemiában
Authors: Fésüs Viktória , Marosvári Dóra , Kajtár Béla , Király Péter Attila , Demeter Judit , Gurbity Pálfi Tímea , Egyed Miklós , Plander Márk , Farkas Péter , Mátrai Zoltán , Matolcsy András , Bödör Csaba 
Published: February 2017

Abstract: Introduction: In recent years much progress has been made in the therapy of chronic lymphocytic leukaemia, as the new innovative medicine proved to be effective in managing patients carrying TP53 abnormalities. To identify all these patients, it is essential to screen for both forms of TP53 defects, including both 17p deletions and TP53 mutations. Aim: The aim of this study was to determine the frequency of TP53 mutations and their association with 17p deletions in a large Hungarian cohort of 196 patients suffering from chronic lymphocytic leukaemia. Method: We performed mutation analysis of TP53 (exons 3–10) using Sanger sequencing. Results: TP53 mutations were present in 15.8% of patients, half of which were associated with 17p deletion. By analysing both forms, TP53 defect was identified in 25.4% of the patients. Conclusions: Our study demonstrates that by performing a TP53 mutation analysis, an additional 10% of high-risk patients can be detected. Orv. Hetil., 2017, 158(6), 220–228.
A comparative study of electrochemical, optical properties and electropolymerization behavior of thiophene- and furan-substituted diketopyrrolopyrrole
Authors: Ponnappa Supreetha Paleyanda , Arumugam Sivanesan , Spratt Henry J. , Manzhos Sergei , O’Mullane Anthony P. , Ayoko Godwin A. , Sonar Prashant 
Published: February 2017

Abstract
KARAKTERISTIK FISIKA KIMIA PERAIRAN DAN STRUKTUR KOMUNITAS ZOOPLANKTON DI ESTUARI SUNGAI BANYUASIN, SUMATERA SELATAN
Authors: Prianto Eko , Husnah Husnah , Aprianti Solekha 
Published: February 2017

Penelitian ini bertujuan untuk mengetahui kondisi kualitas perairan pasca pembangunan Pelabuhan Tanjung Api-Api dengan mempelajari karakteristik fisika kimia perairan dan struktur komunitas zooplankton. Penelitian tentang kelimpahan dan keanekaragaman jenis zooplankton dilakukan melalui enam titik stasiun pengamatan di muara Sungai Banyuasin pada bulan April sampai Nopember 2009. Contoh air diambil pada kedalaman 1 m dari permukaan air dengan menggunakan kemmerer water sampler dan contoh zooplankton diambil dengan menggunakan ember 50 L pada permukaan perairan. Selanjutnya contoh air disaring dengan menggunakan planktonnet dengan ukuran 25 μm. Hasil analisis kualitas air diperoleh nilai parameter (suhu, pH, NO2, COD, BOD, dan DO) berada dalam ambang batas yang diperbolehkan sesuai dengan Peraturan Pemerintah No.82 Tahun 2001. Nilai parameter padatan tersuspensi (total suspended solids), total dissolvedsolid, amoniak, nitrat, dan fosfat telah melebihi ambang batas lingkungan perairan yang diperbolehkan. Nilai indeks mutu lingkungan perairan menunjukan dalam kondisi tercemar berat. Kelimpahan zooplankton pada tahun 2009 yaitu 2-19 ind/L lebih rendah dari kelimpahan pada tahun 2004 yaitu 5- 34 ind/L sedangkan keanekaragaman jenis pada tahun 2009 mengalami penurunan jika dibandingkan tahun 2004. The aims of this study were to determine water quality conditions after construction of the port of Tanjung Api-Api by studying the physico chemical characteristics of water and zooplankton community structure. Research on zooplankton abundance and species diversity through the six points of observation stations in the estuary of the river Banyuasin in April until November 2009. Water samples taken at a depth of 1 m from water surface water by using a kemmerer water sampler and zooplankton samples were taken by using a bucket about 50 L in the surface. Further water samples were filtered using a plankton net with a size 25 μm. The results of water quality analize obtained that parameter values (temperature, pH, NO2, COD, BOD, and DO) were still in the threshold limit, in accordance with Government Regulation No.82 2001. Value parameters of total suspended solids, total dissolved solid, ammonia, nitrate, and phosphate has exceeded the permissible limit aquatic environment. Value of water environmental quality index showed in heavily polluted conditions. Zooplankton abundance in was 2-19 ind/L lower than the abundance in 2004 of 5-34 ind/L, while species diversity in the year 2009 decreased compared to 2004.
SEBARAN UKURAN HASIL TANGKAPAN DAN ASPEK REPRODUKSI IKAN SIDAT (Anguilla bicolor bicolor McClelland, 1844) DI PERAIRAN SEGARA ANAKAN, CILACAP
Authors: Herianti Isnani , Nugroho Duto 
Published: February 2017

Penelitian biologi sumber daya ikan sidat telah dilakukan di perairan Segara Anakan, Cilacap dengan penekanan pada karakteristik biologi berdasarkan atas sebaran ukuran hasil tangkapan dan keragaan aktivitas reproduksi dalam populasi tersebut. Penampilan reproduksi dianalisis melalui pembuatan penampang lintang gonad dengan metode parafin dan pewarnaan hematoxylin ehrlicheosin terhadap contoh yang dianggap mewakili kelompok ukuran panjang. Hasil penelitian ini menunjukan bahwa sebaran frekuensi panjang mempunyai tipe bimodal dengan kecenderungan perbedaan kisaran ukuran berdasarkan atas musim. Rata-rata ukuran panjang hasil tangkapan berdasarkan atas musim menunjukan beda yang sangat nyata (P<0,01). Keragaan aktivitas reproduksi sebagai bagian dari proses penentuan status pemanfaatan memperlihatkan kisaran pada tingkat belum teridentifikasi, belum berkembang sampai tingkat menuju matang gonad. The biological investigation of eel resources have been conducted in Segara Anakan waters,Cilacap District. This study describes the size distribution and variation of its reproductive activity. The reproductive performances were analyzed through cross section of gonad using paraffin method and stained with hematoxylin ehrlich-eosin to the sample that are considered to represent group of length. The result showed that the length frequency are the typically bimodal distribution with tendencies of differences in size based on seasons. The seasonly average length showed a significantly different (P<0.01). Variation in reproductive activity as part of biological indicator of exploitation level showed some differences level of gonad development stages, starting from unidentified, undevelop, until toward mature gonadal levels.
KUALITAS AIR BAGI KEHIDUPAN ORGANISME BAGIAN TENGAH DAN HILIR SUNGAI MUSI BERDASARKAN PADA SUMBER POLUTAN
Authors: Kaban Siswanta , Husnah Husnah , Aida Siti Nurul 
Published: February 2017

Penelitian ini dilakukan untuk mengetahui kualitas air Sungai Musi tahun 2007 sampai dengan 2008 di bagian tengah dan hilir berdasarkan pada sumber polutan. Empat belas stasiun pengambilan contoh ditetapkan sebagai sumber polutan seperti industri maupun pemukiman penduduk, dan referensi yang jauh dari industri maupun pemukiman yang digunakan sebagai pembanding. Pada setiap stasiun, pengambilan contoh dilakukan 3 kali waktu pengambilan, yaitu bulan April, Juni, dan Januari yang dapat mewakili 3 musim yang berbeda pada tahun tersebut. Beberapa parameter diukur in situ sementara beberapa lain dianalisis di laboratorium dengan standar methods (AWWAWEF, 2005). Dari hasil penelitian didapatkan bahwa industri yang bergerak di bidang pengolahan kelapa sawit dan karet cenderung menurunkan kualitas perairan di Sungai Musi. Kandungan logam berat dalam sedimen di Sungai Musi relatif rendah dengan kandungan Cr+6 dan Pb yang tertinggi masing-masing 13,481 dan 1,747 μg per g. Curah hujan cenderung menurunkan beberapa parameter fisika dan kimia kualitas perairan. Potensi pencemaran cenderung ditemukan di bagian hilir Sungai Musi, karena sebaran industri dan intensitas pemanfaatan perairan cukup tinggi di bagian sungai tersebut. Study in order to know distribution of pollution source and its effect on water quality of the middle and down stream of Musi River was conducted in April and June 2007 and January 2008. Fourteen sampling sites were selected based on the pollution source and the minimal degradation site (reference sites). Parameters observed were pollution source distribution and water and sediment parameters such as physical and chemical parameters. Water sample was collected at 0.5 m from water surface by using Kemmerer water sampler while sediment samples were taken by using Ekman grab. Some of the parameters were analyzed in situ while the rest were analyzed in laboratory. Results indicated that oil palm and rubber industries were mostly the pollution source in Musi River. Potential pollution source was mostly found in the middle and down stream of Musi River since most of pollution source and high water utilization found in this area. Water quality parameters except total suspended solid and biochemical oxygen demand, were still in the range that can be tolerated by the aquatic organisms. Rain fall tends to decrease water quality of the river. Concentration of heavy metal such as Chrom (Cr+6) and plumbum in the sediment were in still in low concentration with the highest concentration reaching 13.481 and 1.747 μg per g respectively.
Pathologic Complete Response with Neoadjuvant Doxorubicin and Cyclophosphamide Followed by Paclitaxel with Trastuzumab and Pertuzumab in Patients with HER2-Positive Early Stage Breast Cancer: A Single Center Experience
Authors: Singh Jasmeet C. , Mamtani Anita , Barrio Andrea , Morrow Monica , Sugarman Steven , Jones Lee W. , Yu Anthony F. , Argolo Daniel , Smyth Lilian M. , Modi Shanu , Schweber Sarah , Boafo Camilla , Patil Sujata , Norton Larry , Baselga Jose , Hudis Clifford A. , Dang Chau 
Published: February 2017

Abstract

Objectives
Trastuzumab (H) and pertuzumab (P) with standard chemotherapy is approved for use in the neoadjuvant setting for human epidermal growth receptor 2 -positive patients. A retrospective analysis was performed of patients treated with dose-dense (dd) doxorubicin and cyclophosphamide (AC) followed by paclitaxel (T), trastuzumab, and pertuzumab (THP) in the neoadjuvant setting. Here, the pathologic complete response (pCR) rates are reported.

Methods
An electronic medical record review was conducted of patients treated with HP-based therapy in the neoadjuvant setting from September 1, 2013, to March 1, 2015. Data on patient demographics, stage of breast cancer, pathology reports, surgical data, and information on systemic therapy were collected. The pCR was defined as total (tpCR, ypT0/is ypN0), German Breast Group (GBG) pCR (ypT0 ypN0), breast pCR (bpCR) with in situ disease (ypT0/is) and without in situ disease (ypT0), and explored axillary pCR (ypN0).

Results
Charts from 66 patients were reviewed, and 57 patients were evaluable for pCR. Median age was 46 years (range 26–68 years). Median tumor size was 4 cm. Of 57 patients, 53 (93%) had operable breast cancer (T1-3, N0-1, M0). Three patients (5.3%) had locally advanced disease (T2-3, N2-3, M0 or T4a-c, any N, M0), and 1 (1.7%) had inflammatory breast cancer (T4d, any N, M0). Overall, 44 (77%) and 13 (23%) had hormone receptor (HR)-positive and negative diseases, respectively. Median numbers of cycles of neoadjuvant treatment were as follows: AC (4, range 1–4), T (4, range 1–4), trastuzumab (6, range 3–8), and pertuzumab (6, range 2–8). In these 57 patients, the rates of tpCR and bpCR with in situ disease were demonstrated in 41/57 (72%) patients, and the rates of GBG pCR and bpCR without in situ disease were found in 30/57 (53%) patients. Of 26 patients with biopsy-proven lymph nodal involvement, axillary pCR occurred in 22 (85%) patients.

Conclusion
At a single center, the tpCR and GBG pCR rates of dd AC followed by THP are high at 72% and 53%, respectively.