bluuebunny/crossref_metadata_2025_split huggingface dataset:
Guettarda viburnoides Cham. & Schltdl.: Neuroprotective Activities in Mice, Molecular Docking and Microchemical and Morphoanatomical
Characteristics of Leaves and Stems
Authors: Cruz de Oliveira Junior Pedro , Janet Sanjinez-Argandoña Eliana , Alberto Marangoni Faoro Janaine , Mussury Franco Silva Rosilda Mara , Castelon Konkiewitz Elisabete , Benjamin Ziff Edward , Pereira Cabral Márcia Regina , Sarragiotto Maria Helena , de Freitas Gauze Gisele , Frederico Rozada Andrew Matheus , Mendes Monteiro Luciane , Manfron Jane , Samara Nazari Formagio Anelise 
Published: September 2024

Background:
Guettarda viburnoides Cham. & Schltdl., “veludinho do campo”, is
used in the Brazilian Amazon for its effects on the central nervous system (CNS) as a “brain
tonic”; however, scientific evidence is needed to elucidate its ethnobotanical uses.

Objective:
This study evaluated the neurobehavioural effects of an ethanolic extract of G. viburnoides
(EEGV). Molecular docking, microchemical and morphoanatomical features of the
species were investigated.

Methods:
EEGV was investigated by UHPLC‒MS/MS and dereplication and molecular network
were investigated using platforms available for natural product chemistry. For the in vivo assay,
EEGV was administered to mice orally (3, 30 or 100 mg/kg). The effect of EEGV on spatial
memory was measured using the Morris water maze test in mice with scopolamine-induced amnesia.
The depression- and anxiety-like effects were assessed by forced swimming, tail suspension,
marble burying and elevated plus maze tests. The AChE inhibition was evaluated in the
brains of treated mice and molecular docking simulations were carried out with the main constituents.
The leaves and stems of G. viburnoides were analysed via optical microscopy, scanning
electron microscopy and energy dispersive X-ray spectroscopy.

Results:
Secoxyloganin, grandifloroside, hyperin/or isoquercitrin, uncaric acid and ursolic acid
were identified by UHPLC‒MS/MS. Molecular networking by three flavonoids, three triterpenes,
two coumarins, two iridoids, and one phenolic acid. EEGV reversed these scopolamineinduced
effects. In the forced swim and tail suspension test, EEGV (30 and 100 mg/kg) significantly
reduced the immobility time. EEGV significantly reduced the number of buried marbles,
while in the elevated plus maze test, no changes were observed compared to the Sco group.
AChE activity was altered in the hippocampus. Studies of the molecular coupling of iridoid glycosides
(grandifloroside and secoxyloganin) and flavonoid hyperin with AChE revealed significant
interactions, corroborating the activity indicated by the inhibition assay.

Conclusions:
These results might be in accordance with medicinal use for neuroprotetor effects
and important microchemical and micromorphological data that support the identification and
quality control of G. viburnoides.
Deciphering the Immunomodulatory Pathways of Mesenchymal Stem Cells
Authors: Yuan Fulin , Qi Qi , Wang Lei , Pan Jinhua , Shi Xiaoyu , Zhang Yu 
Published: September 2024

Abstract:
Mesenchymal stem cells (MSCs) are adult stem cells with immunoregulatory abilities
and low immunogenicity, exhibiting powerful immunosuppressive effects in various inflammatory
diseases and holding promise for therapeutic applications. However, the detailed underlying
mechanisms remain unclear. Multiple studies suggest that the immunomodulatory function of
MSCs is primarily based on the release of immunoregulatory factors through paracrine effects,
contributing to their therapeutic outcomes. Other studies report that the immunosuppressive effects
of MSCs are mainly achieved through apoptosis, mitochondrial transfer, and the newly proposed
migrasomes, highlighting their potential clinical implications. We propose a novel hypothesis,
suggesting that migrasomes released by MSCs play a pivotal role in their immunomodulatory
ability, potentially offering new avenues for therapeutic interventions. This article primarily summarizes
the possible mechanisms by which MSCs exert their immunomodulatory effects, focusing
on MSC apoptosis, mitochondrial transfer, and migrasomes, with implications for developing novel
therapeutic strategies.
Impact of Artificial Intelligence on Healthcare Quality: A Systematic Review and Meta-Analysis
Authors: Alzghoul Bashar 
Published: September 2024

Background
Artificial intelligence embodies the ability of computers to emulate human intelligence and generate well-informed choices. Quality within the healthcare domain encompasses adopting proficient, patient-centric, secure, and productive services that are unbiased, comprehensive, punctual, and streamlined. In this regard, this study aimed to investigate the impact of artificial intelligence on healthcare quality. This study echoed the World Health Organization’s findings that artificial intelligence has great potential for distributed clinical automation, delivering efficient clinical information, and offering extra support in healthcare settings.

Methods
This systematic review employed PRISMA methodology and inclusion and exclusion criteria to search through central databases exploring the impact of artificial intelligence on healthcare quality. Specifically, this study concentrated on randomized controlled trials published in PubMed. The search process employed Boolean operators (AND) and (OR) and the main keywords detailed in the methodological section. As a result, two thousand five hundred forty-four sources were identified. The identified sources underwent a rigorous screening process, which entailed the removal of duplication. These eligibility criteria considered studies published in the English language, availability of full text, thorough description of the research aims, objectives, methodology, findings, and conclusion, the number of references, and general presentation. Out of 2544 identified sources, only 18 sources passed the eligibility criteria and were included in this research. The Meta-analysis was conducted using RevMan 5, Mantel-Haenszel, random effect, and 95% confidence intervals.

Results
Overall, the studies were substantially heterogeneous at I2=92%, Z score was 1.93, and the P-value was within the range of less than or equal to 5. Therefore, the general studies provided a significant positive impact of artificial intelligence on healthcare quality. The heterogeneity was minimized through subgroup analysis, where the studies were divided about the objectives. Generally, 6/18 studies yielded an odd ratio of more than 1, reflecting the positive influence of artificial intelligence on healthcare quality. 12/18 studies positively used artificial intelligence in assisted healing or medication adherence, but none were statistically significant.

Conclusion
Artificial intelligence does not directly influence healthcare quality but helps improve other functions within healthcare services. Healthcare quality is comprehensive, encompassing evidence-based practice, patient-centric care, effective communication, care coordination, effective risk management strategies, health information technology, health promotion, and disease prevention.
Pengaruh Harga, Desain Produk, Dan Celebrity Endorsement Terhadap Keputusan Pembelian
Authors: Pradika Vardholi Wahyu , Hussein Ananda Sabil 
Published: September 2024

This study aims to determine the effect of Price, Product Design and Celebrity Endorsement on the purchasing decision of Specs brand soccer shoes. This type of research is explanatory research used to develop and validate causation between variables through hypothesis testing. This study used a sample of 100 respondents who were at least 18 years old, currently or have used soccer shoes from Specs and live in Madiun City. The sampling technique used non-probability sampling with purposive sampling method. The data used is primary data derived from a questionnaire using a seven point Likert Scale. This study uses multiple linear regression analysis method. The results of this study indicate that Price and Product Design have no significant effect on purchasing decisions while Celebrity Endorsement has a significant positive effect on purchasing decisions. This research suggests that companies can maintain and adjust product prices and improve the quality of their product designs and increase celebrity endorsements for their products so that they are expected to influence consumer decisions to make purchases.

Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh Harga, Desain Produk dan Celebrity Endorsement terhadap keputusan pembelian sepatu sepak bola merek Specs. Jenis penelitian ini adalah explanatory research yang digunakan untuk mengembangkan dan memvalidasi sebab akibat antar variabel melalui pengujian hipotesis. Penelitian ini menggunakan sampel sebanyak 100 responden yang berusia minimal 18 tahun, sedang atau pernah menggunakan produk sepatu sepak bola dari Specs dan berdomisili di Kota Madiun. Teknik pengambilan sampel menggunakan non-probability sampling dengan metode purposive sampling. Data yang digunakan adalah data primer yang berasal dari kuesioner dengan menggunakan Skala Likert tujuh poin. Penelitian ini menggunakan metode analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa Harga dan Desain Produk tidak berpengaruh secara signifikan terhadap keputusan pembelian sedangkan Celebrity Endorsement berpengaruh secara positif signifikan terhadap keputusan pembelian. Penelitian ini menyarankan agar perusahaan dapat mempertahankan dan menyesuaikan harga produk dan meningkatkan kualitas dari Desain Produknya serta meningkatkan Celebrity Endorsement pada produknya sehingga diharapkan dapat mempengaruhi keputusan konsumen untuk melakukan pembelian.
Prediksi Keterserapan Siswa SMK Pada Dunia Industri Dengan Pendekatan Educational Data Mining
Authors: Asih Kuri , Wulandhari Lili Ayu 
Published: September 2024

Tingginya tingkat penyerapan tenaga kerja siswa kejuruan sangat menentukan kualitas suatu Sekolah Menengah Kejuruan (SMK). Semakin banyak siswa yang terserap ke dunia kerja dan semakin cepat bekerja setelah lulus maka semakin baik bagi SMK tersebut. Data mining adalah solusi yang berguna untuk mengidentifikasi pola tersembunyi dan memberikan saran untuk meningkatkan kinerja siswa. Penelitian ini menggunakan data rapor dari 167 siswa jurusan Teknik Jaringan Komputer SMK Negeri 26 Jakarta selama enam semester, dari tiga angkatan siswa yang lulus tahun 2015 hingga 2017. Penelitian ini menggunakan model SVR dan ANN dan metode Mean Absolute Error (MAE). Hasil penelitian menunjukkan bahwa ANN dengan data seluruh fitur yang digunakan, dengan model normalisasi Standard Scaler, dan algoritma aktifasi Relu, jumlah Neuron sebanyak 128 dan Iter Max 150 menunjukkan performa terbaik, yaitu MAE sebesar 2,2 bulan. Heatmap korelasi Pearson mengungkapkan bahwa semua mata pelajaran yang sangat erat hubungannya dan mempengaruhi jumlah serapan mahasiswa di dunia kerja adalah mata pelajaran produktif (vokasi) pada semester 1 & 2 pada aspek penilaian keterampilan (praktik). Untuk meningkatkan angka penyerapan tenaga kerja, mahasiswa harus mempertajam dan memperdalam kompetensi mata pelajaran praktik vokasi pada awal semester. Hasil penelitian ini dapat dijadikan acuan untuk memprediksi penyerapan lulusan SMK di dunia kerja dan sebagai langkah antisipatif untuk meningkatkan nilai kompetensi sebelum memasuki dunia kerja.
Dissidentes intelectuais negras: das encruzilhadas epistemológicas aos paradigmas anticoloniais
Authors: Pereira dos Santos Gyme Gessyka 
Published: September 2024

O presente artigo integra parte de uma pesquisa de doutorado já concluída em que foi utilizada também a metodologia de revisão bibliográfica e documental, o objetivo foi estruturar uma análise epistêmica comparada acerca das produções de Bairros (1995), Fernandes (1989), Gonzalez (1984), Hahner (1981) e Nepomuceno (2013) que abordam questões relacionadas à mulher negra na sociedade brasileira, marcadas sobretudo pelo modo como cada intelectual articula as categorias: raça, gênero e classe, bem como o conceito de interseccionalidade. Gonzalez (1984) com exímio pioneirismo traz à baila discussões acerca das condições da mulher negra na sociedade brasileira, com um pertinente e aguçado olhar voltado aos marcadores sociais de gênero, raça e classe, além das fundamentadas e concisas críticas aos cânones sociológicos cisheteropatriarcais, classistas e brancos como: Gilberto Freyre (1933), Florestan Fernandes (1989) e Costa Pinto (1953) que elaboraram estudos distorcidos sobre realidades onde o racismo, o machismo e sexismo perpetraram-se, ao negligenciarem o recorte de raça em especificidade ao gênero, em seus estudos amplamente difundidos e legitimados, ratificaram a naturalização e o fortalecimento de opressões como o racismo, o machismo e o sexismo. Estas opressões combinadas potencializam as situações de vulnerabilidade que atingem especificamente o segmento social feminino negro.
Est-ce possible d’éviter l’obsolescence des humains?
Authors: Depelchin Jacques 
Published: September 2024

En 2010, une de mes sœurs vivant en Belgique nous a envoyé un livre rédigé par Günther Anders Hiroshima est partout et introduit par une préface très élogieuse de Jean-Pierre Dupuy. Ancien étudiant de Martin Heidegger et de Edmund Husserl, Günther Anders avait compris, longtemps avant ses contemporains, à quel point les humains s’étaient trompés sur l’impact que les rapports entre les humains et les machines avait eu sur la déshumanisation. Les machines se sont solidement imposées sur les humains.
Surgery and postoperative definitive radiotherapy for management of canine soft tissue sarcoma: a multi-institutional retrospective study of 272 dogs (2010–2020)
Authors: Hildebrandt Isabella M. , Skinner Owen T. , Mickelson Megan A. , Daniel Todd E. , Ashworth Hayley L. , Kim Annie , Wustefeld-Janssens Brandan G. , Martin Tiffany W. , McKenna Charly , Oblak Michelle L. , Poirier Valerie J. , Randhawa Karanbir , Turek Michelle M. , McAnulty Jonathan F. , Griffin Maureen A. , Duda Lillian E. , Mendez Valenzuela Carlos R. , Vanhaezebrouck Isabelle F. , Sterman Allyson A. , Bloom Christopher , Selmic Laura E. , Fu Dah-Renn , Gutti Jishnu Rao , Nagata Koichi , Thomsen Brian , Vinayak Arathi , Jenei Beatrix , Maitz Charles A. 
Published: September 2024

Abstract

OBJECTIVE
To report local progression and survival in dogs following surgery and postoperative definitive radiotherapy (dRT) for management of soft tissue sarcoma (STS) and to evaluate risk factors for local progression and survival.

METHODS
Records were retrospectively reviewed at 9 referral hospitals for dogs managed with postoperative dRT between January 1, 2010, and January 1, 2020, following surgery for STS. Data related to presentation, surgery, dRT, systemic therapy, and outcome were abstracted. Selected variables were assessed for association with local progression and overall survival.

RESULTS
272 dogs were included. Histologic grade was reported in 249 dogs: 102 were grade 1 (40.9%), 120 were grade 2 (48.2%), and 27 were grade 3 (10.8%). Local progression was suspected or confirmed in 56 dogs. Local progression rates were similar for grade 1 (24 of 89 [26.7%]), grade 2 (23 of 111 [20.7%]), and grade 3 tumors (6 of 22 [27.3%]). Previous recurrence (P = .010) and subsequent distant metastasis (P = .014) were associated with more frequent local progression; intensity-modulated radiotherapy was associated with decreased local progression (P = .025) compared to other forms of delivery. Age (P = .049), grade (P = .009), previous recurrence (P = .009), and institution type for surgery (P = .043) were associated with overall survival.

CONCLUSIONS
Outcomes for most dogs were good; however, the frequency of local progression indicates an ongoing need to critically appraise local management strategies, particularly for low-grade STS. Intensity-modulated radiotherapy was associated with lower rates of local progression and may be preferred to less precise forms of delivery.

CLINICAL RELEVANCE
These data may guide clinicians when making decisions regarding dRT for management of STS.
Improving sensitivity in the deep regions of a volume conductor using electrical focused impedance methods
Authors: Mobarak Mahjabin , Rabbani K Siddique-e 
Published: September 2024

Abstract
Bioimpedance measurements are becoming important in probing the human body for diagnosis and monitoring. An age old 4-electrode technique called tetrapolar impedance measurement (TPIM), giving transfer impedance, cannot localize a specific zone besides having large zones of negative sensitivity. A new technique named the focused impedance method (FIM) from Dhaka University (DU), Bangladesh used the algebraic average of two concentric and orthogonal TPIMs, localizing a zone of interest and having reduced magnitudes of negative sensitivity. Earlier, this was implemented with electrodes applied from one side of the human body giving information to shallow depths only. To get information from deeper regions, specifically, of the thorax, the same DU group placed two electrodes of a 4-electrode version of FIM at the front and two at the back in a horizontal plane of the thorax, using physics-based visualization. This was followed by a few quantitative studies using point sensitivity, which supported the concept. However, more quantitative studies still need to be performed, particularly using objects of finite sizes, in order to establish the technique on a stronger footing. The present study was taken up with this objective. A simplified approach was used in which the volume conductor was a rectangular non-conducting container filled with saline of uniform conductivity with an embedded spherical object – first an insulator and then a conductor. Electrodes were placed at specific chosen positions following the above visualization. Percentage change in transfer impedance with the object placed at different internal positions, compared to that without the object was obtained first using COMSOL simulation and then through experimental measurements. These were performed for both TPIM and FIM. The new configuration of 4-electrode FIM gave good depth sensitivity supporting the effectiveness of the new placement of electrodes.
Determining the Beneficial Owner of Dividend Income Compared to Other Items of Income in International Taxation: nihil sub sōle novum
1
Authors: Kuźniacki Błażej 
Published: September 2024

Abstract
This article focuses on how the concept of beneficial ownership (BO) is determined and applied in international taxation. Although the article analyzes the concept of BO under tax treaties, i.e., the major source of law reducing or eliminating withholding taxation (WHT) on cross-border income at the source state, it is by analogy relevant to European Union (EU) law. The analysis aims to verify whether the meaning of BO in legal provisions regulating WHT on dividend income is the same as under provisions dealing with such taxation on other types of income (typically interest and royalties). The article answers that research question affirmatively, arguing that the concept of BO should be understood in the same way under all provisions concerning WHT on income. This argument follows from the observation that the concept of BO has one and the same income allocation function under these provisions. In contrast, the anti-abusive function should be essentially dismissed, especially in the presence of general anti-abusive rules such as the principal purposes test (PPT) or the general anti-avoidance rule (GAAR). This approach to determining BO is agnostic, and so it applies alike to WHT on income under tax treaties across the globe and EU law.
Religion Acculturation With Merariq Lombok Traditions, A Study Of The Sorong Serah Aji Krama Procession Symbolic Meaning From A Cultural Communication Perspective
Authors: Ikhsan Ikhsan 
Published: September 2024

The blend of cultural and religious values in the Merariq tradition of the Sasak people is closely related to the perspective of artistic communication. Communication and culture have a very close relationship, where one of the main functions of communication is to disseminate culture. The cultural communication process in question encompasses all stages in the Merariq tradition. This research uses qualitative methods with a descriptive qualitative approach and applies Herbert Blumer's symbolic interactionism as the theoretical framework. The study results show that integrating religious and cultural values in the Merariq tradition produces a harmonious blend. This acculturation has elevated the status of both values to a higher level.
Interventive Policing In Natural Disaster Mitigation Through Integrated Technology Application Management In Pulang Pisau District
Authors: Hartono* Kurniawan , Muriman Chairul , Suryadi Suryadi 
Published: September 2024

lectronic Natural disasters in Indonesia from 2014-2023 have caused numerous casualties and infrastructure damage. Disaster mitigation and planning efforts need to be enhanced to reduce future damages. Although information technology such as the Lancang Kuning application, INA-Buoy, INA-CBT, PUMMA, LIPI-WISELAND, LEWS, and FEWS have been utilized for disaster mitigation, there are still weaknesses such as the vulnerability of sensor infrastructure and high operational costs. The role of the Indonesian National Police (Polri) in disaster management is crucial, including protecting lives and property, evacuation, and maintaining security in affected areas. The writing of this article uses a qualitative analysis method supported by institutional theory. The discussion results show that interventive policing is a proactive approach to law enforcement focusing on preventing crimes and disturbances through direct intervention before problems develop into more serious situations. In natural disaster mitigation in Pulang Pisau Regency, this approach involves the use of data and technology to predict and respond early to potential threats. Integrated technology application management becomes an important strategy, utilizing information and communication technology to enhance effectiveness in data collection, early warning, evacuation, and post-disaster recovery.
Analysis of the Financial Performance of PT Bali Bintang Sejahtera Tbk Before and After the IPO (Initial Public Offering) for the 2017-2022 Period
Authors: Fauzian* Refka Aprialda , Kostini Nenden , Sitio Nurul Mardhiah 
Published: September 2024

This research aims to analyze the differences in financial performance of PT Bali Bintang Sejahtera Tbk at the time before and after the Initial Public Offering in 2017 to 2022. The sample of this study is the financial statement data of PT Bali Bintang Sejahtera Tbk from before and after the company conducted an Initial Public Offering (2017-2022). The research method used in testing differences before and after the company conducted an Initial Public Offering is the Paired Sample t-Test and Wilcoxon Sign Test test methods. Then to determine the increase or decrease in the company's financial performance, the average financial ratio test method is used. The results of this study indicate a significant difference in three of the four financial ratios used. The three financial ratios that experienced significant differences after the company conducted an Initial Public Offering included debt to equity ratio, net profit margin, and total assets turnover. Debt to equity ratio and net profit margin increased after the company did an Initial Public Offering, while the total assets turnover ratio decreased. Then only one financial ratio does not experience a significant difference after the company does an Initial Public Offering, namely the current ratio. But the ratio increased after the company did the Initial Public Offering