bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationships between geomechanical properties and lithotypes in NW European chalks
Authors: Descamps Fanny , Faÿ-Gomord Ophélie , Vandycke Sara , Schroeder Christian , Swennen Rudy , Tshibangu Jean-Pierre 
Published: May 2017

Abstract
As a result of increasing interest in unconventional reservoirs, a wide range of sedimentary systems are now being investigated with regard to petroleum applications, including various tight chalk formations. We examined a wide variety of chalk samples from NW Europe (micritic, grainy, argillaceous, marl seam, cemented and silicified chalks) and investigated the relationships between their petrophysical properties, mechanical properties and associated microtextures and how diagenesis can affect these properties. A diagenesis index based on an evaluation of textural and diagenetic parameters was used to quantify the effect of global porosity-reducing diagenesis on the microtexture of chalks. We used petrographic and petrophysical measurements to determine the petrography, density, porosity, permeability and sonic velocity of the chalk samples and uniaxial compression experiments to assess their mechanical behaviour. Our dataset of >30 samples covers a wide range of values for these properties. We determined a linear porosity–permeability relationship controlled by the diagenesis index. Porosity influences the unconfined compressive strength and Young's modulus, but our analyses suggest that the diagenesis of the studied lithologies provides us with a further understanding of the mechanical behaviour of chalks. Micritic and grainy chalks are associated with the lowest diagenesis index and exhibit the lowest strength, whereas the higher diagenesis indices observed for other microtextures correspond to higher compressive strengths.
Predicting transmissibilities of carbonate-hosted fault zones
Authors: Michie E. A. H. , Yielding G. , Fisher Q. J. 
Published: May 2017

Abstract
It is common practice to incorporate deterministic transmissibility multipliers into simulation models of siliciclastic reservoirs to take into account the impact of faults on fluid flow, but this is not common practice in carbonate reservoirs due to the lack of data on fault permeability. Calculation of fault transmissibilities in carbonates is also complicated by the variety of mechanisms active during faulting, associated with their high heterogeneity and increased tendency to react with fluids. Analysis of the main controls on fault-rock formation and permeability from several carbonate-hosted fault zones is used to enhance our ability to predict fault transmissibility. Lithological heterogeneity in a faulted carbonate succession leads to a variety of deformation and/or diagenetic mechanisms, generating several fault-rock types. Although each fault-rock type has widely varying permeabilities, trends can be observed dependent on host lithofacies, juxtaposition and displacement. These trends can be used as preliminary predictive tools when considering fluid flow across carbonate fault zones. Fewer mechanisms occur at lower displacements (<30 m), creating limited fault-rock types with a narrow range of low permeabilities regardless of lithofacies juxtaposition. At increased displacements, more fault-rock types are produced at juxtaposition of different lithofacies, with a wide range of permeabilities.
Myocardial overexpression of TIMP3 after myocardial infarction exerts beneficial effects by promoting angiogenesis and suppressing early proteolysis
Authors: Takawale Abhijit , Zhang Pu , Azad Abul , Wang Wang , Wang Xiuhua , Murray Allan G. , Kassiri Zamaneh 
Published: May 2017

Myocardial infarction (MI) results in loss of cardiomyocytes, adverse extracellular matrix (ECM) and structural remodeling, and left ventricular (LV) dilation and dysfunction. Tissue inhibitors of metalloproteinase (TIMPs) inhibit matrix metalloproteinases (MMPs), the main regulators of ECM turnover. TIMPs also have MMP-independent functions. TIMP3 levels are reduced in the heart within 24 h of MI in mice. We investigated if overexpression of TIMP3 post-MI limits adverse remodeling and LV dilation and dysfunction. MI was induced by left anterior descending coronary artery ligation in 10- to 12-wk-old male C57BL/6J mice, and adenoviral constructs expressing human (h)TIMP3 (Ad-hTIMP3) or no TIMP (Ad-Null) were injected in the peri-infarct zone (5.4 × 107 plaque-forming units/heart, 5 injections/heart). Cardiac function assessed by echocardiography showed improved LV physiology and reduced LV dilation after TIMP3 overexpression compared with the Ad-Null-MI group. Post-MI adverse remodeling was attenuated in the Ad-hTIMP3-MI group, as assessed by greater cardiomyocyte density, less infarct expansion, and ECM disruption. TIMP3 overexpression blunted the early rise in proteolytic activities post-MI. A higher density of coronary arteries and a greater number of proliferating endothelial cells were detected in the infarct and peri-infarct regions in the Ad-hTIMP3-MI group compared with the Ad-Null-MI group. In vitro three-dimensional angiogenesis assay confirmed that recombinant TIMP3 promotes angiogenesis in human endothelial cells, although biphasically and in a dose-dependent manner. Intriguingly, overexpression of Ad-hTIMP3 at 10-fold higher concentration had no beneficial effects, consistent with antiangiogenic effects of TIMP3 at higher doses. In conclusion, optimal overexpression of TIMP3 can be a promising therapeutic approach to limit adverse post-MI remodeling by dually inhibiting early proteolysis and promoting angiogenesis. NEW & NOTEWORTHY Here, we report that tissue inhibitor of metalloproteinase 3 overexpression after myocardial infarction improves myocardial structural remodeling and function by promoting angiogenesis and inhibiting early proteolysis. This demonstrates the therapeutic potential of preserving the local balance of tissue inhibitor of metalloproteinase 3 in the heart given its diverse functions in modulating different processes involved in the adverse postmyocardial infarction remodeling.
Severity of structural and functional right ventricular remodeling depends on training load in an experimental model of endurance exercise
Authors: Sanz-de la Garza Maria , Rubies Cira , Batlle Montserrat , Bijnens Bart H. , Mont Lluis , Sitges Marta , Guasch Eduard 
Published: May 2017

Arrhythmogenic right ventricular (RV) remodeling has been reported in response to regular training, but it remains unclear how exercise intensity affects the presence and extent of such remodeling. We aimed to assess the relationship between RV remodeling and exercise load in a long-term endurance training model. Wistar rats were conditioned to run at moderate (MOD; 45 min, 30 cm/s) or intense (INT; 60 min, 60 cm/s) workloads for 16 wk; sedentary rats served as controls. Cardiac remodeling was assessed with standard echocardiographic and tissue Doppler techniques, sensor-tip pressure catheters, and pressure-volume loop analyses. After MOD training, both ventricles similarly dilated (~16%); the RV apical segment deformation, but not the basal segment deformation, was increased [apical strain rate (SR): −2.9 ± 0.5 vs. −3.3 ± 0.6 s−1, SED vs. MOD]. INT training prompted marked RV dilatation (~26%) but did not further dilate the left ventricle (LV). A reduction in both RV segments' deformation in INT rats (apical SR: −3.3 ± 0.6 vs. −3.0 ± 0.4 s−1 and basal SR: −3.3 ± 0.7 vs. −2.7 ± 0.6 s−1, MOD vs. INT) led to decreased global contractile function (maximal rate of rise of LV pressure: 2.53 ± 0.15 vs. 2.17 ± 0.116 mmHg/ms, MOD vs. INT). Echocardiography and hemodynamics consistently pointed to impaired RV diastolic function in INT rats. LV systolic and diastolic functions remained unchanged in all groups. In conclusion, we showed a biphasic, unbalanced RV remodeling response with increasing doses of exercise: physiological adaptation after MOD training turns adverse with INT training, involving disproportionate RV dilatation, decreased contractility, and impaired diastolic function. Our findings support the existence of an exercise load threshold beyond which cardiac remodeling becomes maladaptive. NEW & NOTEWORTHY Exercise promotes left ventricular eccentric hypertrophy with no changes in systolic or diastolic function in healthy rats. Conversely, right ventricular adaptation to physical activity follows a biphasic, dose-dependent, and segmentary pattern. Moderate exercise promotes a mild systolic function enhancement at the right ventricular apex and more intense exercise impairs systolic and diastolic function.
Green tea epigallocatechin gallate enhances cardiac function restoration through survival signaling expression in diabetes mellitus rats with autologous adipose tissue-derived stem cells
Authors: Chen Tung-Sheng , Liou Show-Yih , Kuo Chia-Hua , Pan Lung-Fa , Yeh Yu-Lan , Liou Jeffery , Padma V. Vijaya , Yao Chun-Hsu , Kuo Wei-Wen , Huang Chih-Yang 
Published: May 2017

The present study tests a hypothesis that cardioprotective effects mediated by autologous adipose-derived stem cells (ADSC) in rats afflicted with insulin-dependent diabetes mellitus (IDDM) may be synergistically enhanced by oral treatment with green tea epigallocatechin gallate (EGCG). Wistar rats were divided into sham, DM, DM+ADSC (autologous transplanted 1 × 106 cells per rat), and DM+ADSC+E (E, green tea oral administration EGCG). Heart tissues were isolated from all rats, and investigations were performed after 2-mo treatment. In the sham, DM, and DM+ADSC groups, we found that DM induced cardiac dysfunction (sham and DM) and autologous ADSC transplantation could partially recover cardiac functions (DM and DM+ADSC) in DM rats. Compared with DM+ADSC, significant improvement in cardiac functions can be observed in DM+ADSC+E in echocardiographic data, histological observations, and even cellular protein expression. Oral green tea EGCG administration and autologous ADSC transplantation show synergistically beneficial effects on diabetic cardiac myopathy in DM rats. NEW & NOTEWORTHY Cardiomyopathy can be induced in rats with diabetes mellitus (DM). Heart function can be restored in DM rats with adipose-derived stem cell treatment. Oral epigallocatechin gallate (EGCG) administration synergistically enhances cardiac function in DM rats with stem cell treatment. The EGCG and stem cell treatment cross-effect occurs via survival protein expression.
<b>A comparative study of avian diversity in Teknaf Wildlife Sanctuary, Inani Reserve Forest and Chittagong University campus in Bangladesh</b>
Authors: Ahsan M. Farid , Haidar Ibrahim Khalil Al 
Published: May 2017

We performed a comparative study of birds in Teknaf Wildlife Sanctuary (TWS), Inani Reserve Forest (IRF) and the Chittagong University Campus (CUC) in 2015. A total of 249 species belonging to 50 families were recorded: 210 species from 46 families in TWS, 187 species from 45 families in IRF, and 182 species from 45 families in CUC. Of these, 181 species (73%) were resident, 57 (23%) winter visitors, three (1.20%) summer visitors, two (0.80%) passage migrants and five (2%) vagrants. According to their frequency of occurrence, 73 species (29.32%) were very common, 66 (26.5%) common, 62 (25%) uncommon and 48 (19%) rare. 120 species (48%) were passerines (97 in TWS, 95 in IRF and 97 in CUC) and 129 (52%) non-passerines (113 in TWS, 92 in IRF and 85 in CUC). Among the three areas, TWS had the greatest diversity in terms of total species, (210˃187˃182), residents (161˃148˃134), non-residents (49˃48˃39), forest indicator birds (47˃44˃31) and wading birds (48˃34˃24).
<b>Butterflies of the Kole Wetlands, a Ramsar Site in Kerala, India</b>
Authors: Sarath S. , Sreekumar E. R. , Nameer P. O. 
Published: May 2017

A study was conducted to understand the diversity and abundance of butterflies of Kole Wetlands. Fifty-eight species in five families were identified. The relative abundance and seasonal variation in the abundance across the year have been discussed. The endemism as well as the butterflies listed in the schedules of the Wildlife (Protection) Act, 1972 have also been discussed.
Regional Pediatric Acute Stroke Protocol
Authors: Tabone Laurence , Mediamolle Nicolas , Bellesme Celine , Lesage Fabrice , Grevent David , Ozanne Augustin , Naggara Olivier , Husson Beatrice , Desguerre Isabelle , Lamy Catherine , Denier Christian , Kossorotoff Manoelle 
Published: May 2017

Background and Purpose—
To evaluate hyperacute management of pediatric arterial ischemic stroke, setting up dedicated management pathways is the first recommended step to prove the feasibility and safety of such treatments. A regional pediatric stroke alert protocol including 2 centers in the Paris-Ile-de-France area, France, was established.

Methods—
Consecutive pediatric patients (28 days–18 years) with confirmed arterial ischemic stroke who had acute recanalization treatment (intravenous r-tPA [recombinant tissue-type plasminogen activator], endovascular procedure, or both) according to the regional pediatric stroke alert were retrospectively reviewed during a 40-month period.

Results—
Thirteen children, aged 3.7 to 16.6 years, had recanalization treatment. Median time from onset to magnetic resonance imaging was 165 minutes (150–300); 9 out of 13 had large-vessel occlusion. Intravenous r-tPA was used in 11 out of 13 patients, with median time from onset to treatment of 240 minutes (178–270). Endovascular procedure was performed in patients time-out for intravenous r-tPA (n=2) or after intravenous r-tPA inefficiency (n=2). No intracranial or peripheral bleeding was reported. One patient died of malignant stroke; outcome was favorable in 11 out of 12 survivors (modified Rankin Scale score 0–2).

Conclusions—
Hyperacute recanalization treatment in pediatric stroke, relying on common protocols and adult/pediatric ward collaboration, is feasible. Larger systematic case collection is encouraged.
Reciprocal Interaction of 24-Hour Blood Pressure Variability and Systolic Blood Pressure on Outcome in Stroke Thrombolysis
Authors: Kellert Lars , Hametner Christian , Ahmed Niaz , Rauch Geraldine , MacLeod Mary J. , Perini Francesco , Lees Kennedy R. , Ringleb Peter A. 
Published: May 2017

Background and Purpose—
Significance and management of blood pressure (BP) changes in acute stroke care are unclear. Here, we aimed to investigate the impact of 24-hour BP variability (BPV) on outcome in patients with acute ischemic stroke treated with intravenous thrombolysis.

Methods—
From the Safe Implementation of Treatment in Stroke International Stroke Thrombolysis registry, 28 976 patients with documented pre-treatment systolic BP at 2 and 24 hours were analyzed. The primary measure of BP variability was successive variability. Data were preprocessed using coarsened exact matching. We assessed early neurological improvement, symptomatic intracerebral hemorrhage (SICH), and long-term functional outcome (modified Rankin Scale [mRS] at 90 days) by binary and ordinal regression analyses.

Results—

Attempts to explain successive variation for analysis of BPV with patients characteristics at admission found systolic BP (5.5% variance) to be most influential, yet 92% of BPV variance remained unexplained. Independently from systolic BP, successive variation for analysis of BPV was associated with poor functional outcome mRS score of 0 to 2 (odds ratio [OR], 0.94; 95% confidence interval [CI], 0.90–0.98), disadvantage across the shift of mRS (OR, 1.04; 95% CI, 1.01–1.08), mortality (OR, 1.10; 95% CI, 1.01–1.08), SICH
SITS
(OR, 1.14; 95% CI, 1.06–1.23), and SICH
ECASS
(OR, 1.24; 95% CI, 1.10–1.40; ECASS [European Cooperative Acute Stroke Study 2]). Analyzing successive variation for analysis of BPV as a function of pre-treatment, systolic BP significantly improved the prediction of functional outcome (mRS score of 0–1, mRS score of 0–2, neurological improvement, mRS-shift: all
P
interaction
<0.01). Excluding patients with atrial fibrillation in a sensitivity analysis gave consistent results overall.

Conclusions—
This study suggests the need for a more individual BP management accounting for pre-treatment BP and the acute BP course (ie, BPV) to achieve best possible outcome for the patient.
‘I have potential’: Experiences of recovery in the individual placement and support intervention
Authors: Gammelgaard Iben , Christensen Thomas N , Eplov Lene F , Jensen Sofie B , Stenager Elsebeth , Petersen Kirsten S 
Published: May 2017

Background: The individual placement and support (IPS) intervention supports persons with severe mental illness in achieving competitive employment. Although the IPS intervention is labelled a recovery-oriented intervention, little is known about how participants experience IPS to influence recovery. The aim was to investigate how IPS and employment influence recovery in persons with severe mental illness. Material: A qualitative phenomenological hermeneutic study of experiences of 12 participants in IPS. Discussion and conclusion: IPS and competitive work have an impact on personal recovery, may influence work functioning and decrease depressive symptoms, but do not seem to have an impact on psychotic symptoms.
The Psychiatric Morbidity of Women Who Give Birth to Children with Fetal Alcohol Spectrum Disorder (FASD): Results of the Manitoba Mothers and FASD Study
Authors: Singal Deepa , Brownell Marni , Chateau Dan , Hanlon-Dearman Ana , Longstaffe Sally , Roos Leslie L. 
Published: May 2017

Objective:To investigate differences in physician-diagnosed psychiatric disorders between women who gave birth to children with a fetal alcohol spectrum disorder (FASD) diagnosis (study group) compared to women who gave birth to children without FASD (comparison group).Methods:We linked population-level health and social services data to clinical data on FASD diagnoses to identify study group ( n = 702) and comparison group ( n = 2097) women matched 1:3 on date of birth of index child, region of residence, and socioeconomic status. Regression modeling produced relative rates (RRs) for outcomes.Results:Mothers who gave birth to children with FASD had higher adjusted rates of substance use disorder (RR, 12.65; 95% confidence interval [CI], 8.99-17.80), personality disorder (RR, 12.93; 95% CI, 4.88-34.22), and mood and anxiety disorders (RR, 1.75; 95% CI, 1.49-2.07) before the pregnancy of the child. These mothers also had higher adjusted rates of maternal psychological distress during pregnancy (RR, 5.35; 95% CI, 4.58-6.35) and higher rates of postpartum psychological distress (RR, 1.71; 95% CI, 1.53-1.90). These women also had higher adjusted rates for antidepressant prescriptions before, during, and after the pregnancy.Conclusions:A significant psychiatric burden exists for women giving birth to children with FASD. Clinicians should recognise the high rates of psychiatric concerns facing mothers who give birth to children with FASD and should offer treatment and support to these women to improve their health and well-being and prevent further alcohol-exposed pregnancies.
Psychotropic Drug Use before, during, and after Pregnancy: A Population-Based Study in a Canadian Cohort (2001-2013)
Authors: Leong Christine , Raymond Colette , Château Dan , Dahl Matthew , Alessi-Severini Silvia , Falk Jamie , Bugden Shawn , Katz Alan 
Published: May 2017

Objective:To describe the extent of increase in use and the rate of continuation versus discontinuation of psychotropic agents before, during, and after pregnancy.Methods:Rates of psychotropic use (antidepressants, anxiolytic/sedative-hypnotics, antiepileptics, antipsychotics, lithium, stimulants) among women with a hospital-recorded pregnancy outcome were assessed using databases at the Manitoba Centre for Health Policy. Rate of use was defined as ≥1 prescription over the total number of pregnancies in the 3-12 months before pregnancy, 0-3 months before pregnancy, during pregnancy, or 3 months after pregnancy. Continued use was defined as ≥2 prescriptions with gap ≤14 days. Poisson regression was used to analyze trends.Results:Over the study period, a psychotropic drug was used before, during, or after pregnancy in 41,923 of 224,762 pregnancies. From 2001 to 2013, psychotropic use increased 1.5-fold from 11.1% to 16.2% ( p < 0.0001) in the 3-12 months before pregnancy, 1.6-fold from 6.4% to 10.5% ( p < 0.0001) in the 3 months before pregnancy, 1.8-fold from 3.3% to 6.0% ( p < 0.0001) during pregnancy, and 1.5-fold from 6.2% to 9.5% ( p < 0.0001) in the 3 months postpartum. Among the 13,579 women who received at least 1 psychotropic agent in the 3 months prior to pregnancy, 38.5% stopped the agent prior to pregnancy and only 10.3% continued use throughout pregnancy. Continued use throughout pregnancy was higher (56.9%) among the 6693 women who received at least 2 prescriptions for a psychotropic agent and were at least 80% adherent in the 3 months prior to pregnancy.Conclusion:The use of psychotropic agents increased over 12 years. The safety of continuing versus discontinuing these agents during pregnancy remains uncertain, but we observed a decrease in psychotropic drug use during the pregnancy period.
Preventing Underfeeding and Overfeeding: A Clinician’s Guide to the Acquisition and Implementation of Indirect Calorimetry
Authors: Ladd Amy K. , Skillman Heather E. , Haemer Matthew A. , Mourani Peter M. 
Published: May 2017

AbstractBackground: In critically ill patients, indirect calorimetry (IC) is the gold standard to determine energy needs, as the use of predictive equations can result in underfeeding or overfeeding. The aim of this quality improvement (QI) initiative was to describe the rationale for and implementation of a process to target energy provision according to IC measurements in a tertiary academic medical center pediatric intensive care unit (PICU). Materials and Methods: To justify the purchase of an indirect calorimeter for clinical use, a needs assessment was conducted, followed by a training and implementation period. PICU patients were selected for IC according to published guidelines. Measured energy expenditure was compared with predicted energy expenditure and the provided energy prescription. The dietitians assessed IC results and adjusted energy prescriptions, if indicated. Results: Thirty‐five total tests were completed with 24 patients. Sixty‐nine percent of measurements resulted in energy delivery adjustments. Fifteen (47%) energy prescriptions decreased by a mean of 27% ± 11%, and 7 (22%) increased by a mean of 17% ± 15%. Staff and patient/guardians accommodated the use of IC, and PICU dietitian recommendations for IC tests and to adjust nutrition regimens were universally implemented. Conclusions: Data to support the procurement of IC are vital to promote best practice to measure energy expenditure. Critically ill pediatric patients exhibit metabolic alterations that cannot be predicted by standard equations. Our QI initiative demonstrated the implementation and application of IC in the critically ill population and the ability to target energy provision to prevent energy imbalances.