bluuebunny/crossref_metadata_2025_split huggingface dataset:
Meningkatkan produksi punch dengan membuat Rangkaian heater automatic run pada proses departmen workshop PT. XYZ
Authors: SUTARDJO YUDHA WITANTO 
Published: October 2024

Pada Produksi tahun 2023 dengan meningkatnya permintaan punch dari departemen produksi yang mengharuskan peningkatan produksi punch. Dari hasil kajian analisa team engineering dan kajian perhitungan proses produksi di departmen workshop PT. XYZ terdapat peluang perbaikan yaitu membuat model sistem otomatis dalam menghidupkan pemanas atau heater pada meja produksi punch. Untuk memastikan rangkaian heater automatic run dan berfungsi baik, ada beberapa tahapan proses dilakukan yaitu pengumpulan data dan survei lapangan, membuat gambar rancangan, Penyiapan bahan dan komponen, Pembuatan dan perakitan panel control dan Uji fungsi. Dari hasil pembuatan rangkaian heater automatic run setelah berfungsi dengan baik menunjukkan terdapat penambahan waktu efektif kerja, yang selama ini 2 jam dijadikan proses persiapan, sehingga efektifitas waktu 5 jam naik menjadi 7 jam, dengan penambahan jumlah produksi punch dalam 1 hari kerja dari 15 punch menjai 21 punch , naik 40% , dari sebelum dan sesudah dilakukan penambahan rangkaian heater automatic run.
Establishment of a platform based on dual RPA combined with CRISPR/Cas12a for the detection of Klebsiella pneumoniae and its KPC resistance gene
Authors: Tan Meiying , Yi Xueli , Liao Chuan , Zhou Zihan , Ren Baoyan , Liang Lina , Li Xuebin , Wei Guijiang 
Published: October 2024

Carbapenem resistant Klebsiella pneumoniae (CRKP) can cause serious hospital- and community-acquired infections. Treatment for CRKP infection is limited, resulting in prolonged hospitalization and high consultation costs. The KPC genotype has the highest detection rate of CRKP, and its mortality rate is higher than the overall mortality rate of CRKP. However, traditional testing methods have disadvantages such as long time and reliance on complex and sophisticated instruments, which are not conducive to rapid screening for CRKP. Therefore, this study aimed to establish a detection platform for early screening of CRKP so that effective antimicrobial therapy could be administered promptly to prevent the widespread spread of CRKP. We integrated dual RPA with CRISPR/Cas12a to establish a dual platform for the detection of K. pneumoniae (Kp) rcsA-specific gene and KPC resistance gene. Four result reading methods were established, including fluorescence detection (FD), blue light irradiation detection (BLID), ultraviolet irradiation detection (UID), and lateral flow test strips (LFTS). For the rcsA gene, the LOD of FD was 1 × 10 pg/μL, and the other three methods could detect 1 × 101 pg/μL of bacterial DNA. As for the KPC gene, four resultant readout methods were able to detect 1 × 102 pg/μL of bacterial DNA. In 59 clinical strains tested, the dual RPA-CRISPR/Cas12a detection of the rcsA had 100% sensitivity, specificity, and accuracy compared to the culture method. Compared with the drug sensitivity test, the sensitivity of dual RPA-CRISPR/Cas12a detection for the KPC was 85.71%, the specificity was 100%, and the accuracy was 94.92%. In summary, our dual RPA-CRISPR/Cas12a platform proved to be rapid, precise, and convenient for the efficient detection of Kp with KPC in the laboratory or at the point of care.
Fluorinated aggregated nanocarbon with high discharge voltage as cathode materials for alkali-metal primary batteries
Authors: Chen Huixin , Yan Ke , Zou Yan , Xia Qi , Kang Xiaoyu , Yue Hongjun , Chen Ding 
Published: October 2024

Due to its exceptionally high theoretical energy density, fluorinated carbon has been recognized as a strong contender for the cathode material in lithium primary batteries particularly valued in aerospace and related industries. However, CFx cathode with high F/C ratio, which enables higher energy density, often suffer from inadequate rate capability and are unable to satisfy escalating demand. Furthermore, their intrinsic low discharge voltage imposes constraints on their applicability. In this study, a novel and high F/C ratio fluorinated carbon nanomaterials (FNC) enriched with semi-ionic C–F bonds is synthesized at a lower fluorination temperature, using aggregated nanocarbon as the precursor. The increased presence semi-ionic C–F bonds of the FNC enhances conductivity, thereby ameliorating ohmic polarization effects during initial discharge. In addition, the spherical shape and aggregated configuration of FNC facilitate the diffusion of Li+ to abundant active sites through continuous paths. Consequently, the FNC exhibits high discharge voltage of 3.15 V at 0.01C and superior rate capability in lithium primary batteries. At a high rate of 20C, power density of 33,694 W kg–1 and energy density of 1,250 Wh kg–1 are achieved. Moreover, FNC also demonstrates notable electrochemical performance in sodium/potassium-CFx primary batteries. This new-type alkali-metal/CFx primary batteries exhibit outstanding rate capability, rendering them with vast potential in high-power applications.
Campylobacter coli of porcine origin exhibits an open pan-genome within a single clonal complex: insights from comparative genomic analysis
Authors: Ghatak Sandeep , Milton Arockiasamy Arun Prince , Das Samir , Momin Kasanchi M. , Srinivas Kandhan , Pyngrope Daniel Aibor , Priya G. Bhuvana 
Published: October 2024

IntroductionAlthough Campylobacter spp., including Campylobacter coli, have emerged as important zoonotic foodborne pathogens globally, the understanding of the genomic epidemiology of C. coli of porcine origin is limited.MethodsAs pigs are an important reservoir of C. coli, we analyzed C. coli genomes that were isolated (n = 3) from pigs and sequenced (this study) them along with all other C. coli genomes for which pig intestines, pig feces, and pigs were mentioned as sources in the NCBI database up to January 6, 2023. In this paper, we report the pan-genomic features, the multi-locus sequence types, the resistome, virulome, and mobilome, and the phylogenomic analysis of these organisms that were obtained from pigs.Results and discussionOur analysis revealed that, in addition to having an open pan-genome, majority (63%) of the typeable isolates of C. coli of pig origin belonged to a single clonal complex, ST-828. The resistome of these C. coli isolates was predominated by the genes tetO (53%), blaOXA-193 (49%), and APH (3′)-IIIa (21%); however, the virulome analysis revealed a core set of 37 virulence genes. Analysis of the mobile genetic elements in the genomes revealed wide diversity of the plasmids and bacteriophages, while 30 transposons were common to all genomes of C. coli of porcine origin. Phylogenomic analysis showed two discernible clusters comprising isolates originating from Japan and another set of isolates comprising mostly copies of a type strain stored in three different culture collections.
Women's mental health and COVID-19: increased vulnerability and inequalities
Authors: Arilha Margareth , Carvalho Adriana P. , Forster Thais A. , Rodrigues Carla V. M. , Briguglio Bianca , Serruya Suzanne J. 
Published: October 2024

IntroductionThe impact of COVID-19 on mental health has become a relevant object of research. Studies have demonstrated that women have experienced greater mental health challenges, highlighting the importance of public health systems to address women's specific needs.MethodsThis literature review explores the effects of the coronavirus pandemic on psychological distress among women, aiming to provide a comprehensive understanding of the subject and to explore how these research findings can guide public mental health care responses in crisis settings. A total of 131 studies were analyzed and four dimensions were discussed: study characteristics, factors impacting women's mental health in the pandemic setting, particularities of pregnancy and the postpartum period, and proposed interventions. Most studies exclusively addressed populations of adult women, predominantly during pregnancy and the postpartum period.ResultsAnxiety, depression, and stress were the most common outcomes. Lower education and income, preexisting mental health problems, and living alone or with children were risk factors for higher levels of anxiety and depression.DiscussionA comprehensive care approach supported by public health policies and focused on intersectional factors, including race, socioeconomic status, and access to resources, is necessary to improve women's mental health care response in future crises.
Risk factors for poor prognosis in patients with zoster-associated neuralgia who underwent interventional pain management
Authors: Yuan Junpeng , Yu Youjia , Liu Hong , Xu Huichan , Li Yan , Jin Xiaohong 
Published: October 2024

BackgroundZoster-associated neuralgia (ZAN) is recognized as a challenging neuralgia that often leads to poor prognosis in patients receiving interventional pain management. Identifying risk factors early can enable clinicians to develop personalized treatment plans; however, research in this area is limited.MethodsWe retrospectively screened all patients with ZAN who received interventional therapy in the Pain Department of Soochow University First Affiliated Hospital from January 1, 2022 to August 31, 2023. Data on patient demographics, medical history, neutrophil-to-lymphocyte ratio (NLR), clinical scoring, and treatment methods were collected. Interventional therapy included short-term nerve electrical stimulation (st-NES), pulsed radiofrequency (PRF) and radiofrequency thermocoagulation (RF-TC). Patients were categorized into poor prognosis and control groups based on outcomes 3 months post-discharge. Multivariate logistic regression was used to identify risk factors for poor prognosis.ResultsThe final analysis included 282 patients. The rate of poor prognosis was 32.6% (92/282). Multivariate logistic regression analysis revealed that age ≥ 65 years (odds ratio, 2.985; 95% confidence interval, 1.449–6.148; p = 0.003), disease duration &gt;3 months (odds ratio, 3.135; 95% confidence interval, 1.685–5.832; p &lt; 0.001), head and face pain (odds ratio, 3.140; 95% confidence interval, 1.557–6.330; p = 0.001), use of immunosuppressants (odds ratio, 2.737; 95% confidence interval, 1.168–6.416; p = 0.021), higher NLR (odds ratio, 1.454; 95% confidence interval, 1.233–1.715; p &lt; 0.001), PRF (st-NES as reference) (odds ratio, 2.324; 95% confidence interval, 1.116–4.844; p = 0.024) and RF-TC (st-NES as reference) (odds ratio, 5.028; 95% confidence interval, 2.139–11.820; p &lt; 0.001) were found to be independent risk factors for poor prognosis in patients with ZAN who underwent interventional pain management.ConclusionAge ≥ 65 years (odds ratio, 2.985; 95% confidence interval, 1.449–6.148; p = 0.003), disease duration &gt;3 months (odds ratio, 3.135; 95% confidence interval, 1.685–5.832; p &lt; 0.001), head and face pain (odds ratio, 3.140; 95% confidence interval, 1.557–6.330; p = 0.001), immunosuppressants use (odds ratio, 2.737; 95% confidence interval, 1.168–6.416; p = 0.021), higher NLR (odds ratio, 1.454; 95% confidence interval, 1.233–1.715; p &lt; 0.001), PRF (odds ratio, 2.324; 95% confidence interval, 1.116–4.844; p = 0.024) and RF-TC (odds ratio, 5.028; 95% confidence interval, 2.139–11.820; p &lt; 0.001) were identified as independent risk factors for poor prognosis in patients with ZAN who underwent interventional pain management.
Dietary astragalin confers protection against lipopolysaccharide-induced intestinal mucosal barrier damage through mitigating inflammation and modulating intestinal microbiota
Authors: Tang Enhui , Lin Huan , Yang Yihao , Xu Jiawen , Lin Baiwen , Yang Yang , Huang Zijian , Wu Xinlan 
Published: October 2024

IntroductionThe intestinal mucosal barrier (IMB) damage is intricately linked with the onset of numerous intestinal diseases. Astragalin (AS), a flavonoid present in numerous edible plants, exhibits notable antioxidant and anti-inflammatory properties, demonstrating a promising impact on certain intestinal ailments. In this study, our objective was to investigate the protective effects of AS and elucidate the underlying mechanisms by which it mitigates lipopolysaccharide (LPS)-induced damage to the IMB in mice.MethodsDuring the experimental period, mice were subjected to a 7-day regimen of AS treatment, followed by LPS injection to induce IMB damage. Subsequently, a comprehensive evaluation of relevant biological indicators was conducted, including intestinal pathological analysis, serum inflammatory factors, intestinal tight junction proteins, and intestinal microbiota composition.ResultsOur results suggested that AS treatment significantly bolstered IMB function. This was evidenced by the enhanced morphology of the small intestine and the elevated expression of tight junction proteins, including ZO-1 and Claudin-1, in addition to increased levels of MUC2 mucin. Moreover, the administration of AS demonstrated a mitigating effect on intestinal inflammation, as indicated by the reduced plasma concentrations of pro-inflammatory cytokines such as IL-6, IL-1β, and TNF-α. Furthermore, AS treatment exerted a positive influence on the composition of the gut microbiota, primarily by augmenting the relative abundance of beneficial bacteria (including Lachnospiracea and Lactobacillus murinus), while simultaneously reducing the prevalence of the harmful bacterium Mucispirillum schaedleri.ConclusionAS mitigates LPS-induced IMB damage via mitigating inflammation and modulating intestinal microbiota.
A guide to global access to HPV vaccination to all women in low- and middle-income countries; a minireview of innovation and equity
Authors: Ewongwo Agnes , Sahor Aji Fatou , Ngwa Wilfred , Nwachukwu Chika 
Published: October 2024

IntroductionCervical cancer is caused by the human papillomavirus (HV), and accounts for more than 311,000 preventable deaths annually, with 85% occurring in low-and middle-income countries. Despite being preventable through screening and screening, significant barriers to implementing HPV vaccination persist in developing nations. This review study aims to identify these barriers and propose innovative, evidence-based solutions to improve vaccination rates and reduce cervical cancer mortality.MethodsA systematic review search was conducted using PubMed, Embase, and Cochrane Database of Systemic Reviews. Keywords related to HPV vaccination barriers and implementation strategies in developing countries were used. Relevant demonstration projects, pilot studies, and evidence-based research articles were reviewed.ResultsIdentifiable barriers to a successful vaccine implementation program in a developing country include vaccine costs, societal, cultural resistance, misinformation, logistical challenges in vaccine delivery, and inadequate human resources. Solutions to these barriers include a subsidized vaccine pricing, community sensitization, education and well-trained media professionals to dispel misinformation, and partnerships with both public and private sector for efficient vaccine distribution.DiscussionThese findings highlight critical barriers that impede HPV vaccination efforts in developing countries and offers practical solutions to overcome these challenges. This aggregate of data can help inform future developing countries’ implementation programs to further the World Health Assembly mission to vaccinate 90% of eligible girls globally by 2030.
Salidroside may target PPARα to exert preventive and therapeutic activities on NASH
Authors: Chu Xueru , Liu Shousheng , Qu Baozhen , Xin Yongning , Lu Linlin 
Published: October 2024

BackgroundSalidroside (SDS), a phenylpropanoid glycoside, is an antioxidant component isolated from the traditional Chinese medicine Rhodiola rosea and has multifunctional bioactivities, particularly possessing potent hepatoprotective function. Non-alcoholic steatohepatitis (NASH) is one of the most prevalent chronic liver diseases worldwide, but it still lacks efficient drugs. This study aimed to assess the preventive and therapeutic effects of SDS on NASH and its underlying mechanisms in a mouse model subjected to a methionine- and choline-deficient (MCD) diet.MethodsC57BL/6J mice were fed an MCD diet to induce NASH. During or after the formation of the MCD-induced NASH model, SDS (24 mg/kg/day) was supplied as a form of diet for 4 weeks. The histopathological changes were evaluated by H&amp;E staining. Oil Red O staining and Sirius Red staining were used to quantitatively determine the lipid accumulation and collagen fibers in the liver. Serum lipid and liver enzyme levels were measured. The morphology of autophagic vesicles and autophagosomes was observed by transmission electron microscopy (TEM), and qRT-PCR and Western blotting were used to detect autophagy-related factor levels. Immunohistochemistry and TUNEL staining were used to evaluate the apoptosis of liver tissues. Flow cytometry was used to detect the composition of immune cells. ELISA was used to evaluate the expression of serum inflammatory factors. Transcript–proteome sequencing, molecular docking, qRT-PCR, and Western blotting were performed to explore the mechanism and target of SDS in NASH.ResultsThe oral administration of SDS demonstrated comprehensive efficacy in NASH. SDS showed both promising preventive and therapeutic effects on NASH in vivo. SDS could upregulate autophagy, downregulate apoptosis, rebalance immunity, and alleviate inflammation to exert anti-NASH properties. Finally, the results of transcript–proteome sequencing, molecular docking evaluation, and experimental validation showed that SDS might exert its multiple effects through targeting PPARα.ConclusionOur findings revealed that SDS could regulate liver autophagy and apoptosis, regulating both innate immunity and adaptive immunity and alleviating inflammation in NASH prevention and therapy via the PPAR pathway, suggesting that SDS could be a potential anti-NASH drug in the future.
Exploring factors affecting nurse anxiety in Northwest Ethiopia: a multicenter study
Authors: Misganaw Adane , Hailu Mignot , Bayleyegn Gashachew , Aderaw Mekidem , Yigzaw Zeamanuel Anteneh , Alemu Tihtna , Asmare Lakew 
Published: October 2024

IntroductionAnxiety is a commonly reported mental health disorder that significantly contributes to the global burden of disease. However, proper counseling, problem-solving strategies, and promotion of healthy lifestyle practices have a positive effect on reducing nurse anxiety, but there is limited evidence in Ethiopia, particularly in this study area. Therefore, this study aimed to assess the prevalence and identify factors affecting nurse anxiety in Northwest Ethiopia’s comprehensive specialized hospitals.MethodsAn institution-based cross-sectional study was conducted among 746 study participants from April 14 to May 20, 2023. A simple random sampling technique was used. An interviewer-administered questionnaire was used. Data were entered into EpiData version 4.6.0 and exported to STATA version 17 for analysis. In binary logistic regression, variables with a p-value of less than 0.25 were considered candidates for multivariable logistic regression. An association was declared at a p-value of less than 0.05 with a 95% confidence interval.ResultIn this study, the prevalence of anxiety was 33.9%. Thus, being female [adjusted odds ratios (AOR) = 1.53, 95% CI = 1.08, 2.22], working in an emergency department (AOR = 3.65, 95% CI = 1.83, 7.28), working night duty shifts (AOR = 3.12, 95% CI = 2.19, 4.46), having conflict with coworkers (AOR = 1.7, 95% CI = 1.14, 2.51), and having poor social support (AOR = 2.13, 95% CI = 1.23, 3.69) were variables significantly associated with anxiety.ConclusionThis study revealed that one-third of nurses experienced anxiety, which is a critical indicator of mental health within this population. Important factors that were found to be significantly associated with anxiety include being female, working in the emergency department, having a conflict with coworkers, having poor social support, and working night duty shifts. These findings show the need for the implementation of counseling services and the adaptation of effective coping strategies for nurses working at comprehensive specialized hospitals. Understanding the impact of anxiety on nurses is important to design interventions aimed at improving their mental health and job satisfaction.
Analysis of the global burden of cardiovascular diseases linked to exposure to ambient particulate matter pollution from 1990 to 2019
Authors: Zou Binbin , Wu Ping , Luo Juan , Li Le , Zhou Ming 
Published: October 2024

BackgroundThis research endeavors to scrutinize the temporal trends and global burden of cardiovascular diseases (CVDs) associated with ambient particulate matter (PM) pollution spanning from 1990 to 2019.MethodsAge-standardized death rates (ASDRs) and age-standardized disability-adjusted life years (DALYs) for CVDs, as well as their estimated annual percentage changes (EAPCs), were calculated using data from the Global Burden of Disease Study 2019 (GBD 2019).ResultsThe global ASDR and age-standardized DALYs due to CVDs associated with PM pollution increased from 1990 to 2019, with a higher increase in males. The burden was higher among middle-aged and older adults. The ASDR and DALYs increased in low-Socio-demographic Index (SDI), low–middle-SDI, and middle-SDI countries, while they decreased in high-SDI countries. The highest burden was observed in Central Asia, North Africa, the Middle East, East Asia, and South Asia. The highest burdens were reported in Iraq, Egypt, and Uzbekistan at the national level.ConclusionThe burden of CVDs linked to PM pollution has grown significantly from 1990 to 2019, with variations across regions and countries, highlighting the need for targeted prevention and pollution management strategies.
Mediastinal drainage combined with upper mediastinal re-tunneling vs. mediastinal drainage alone in McKeown esophagectomy of esophageal cancer: a retrospective study
Authors: Dai Lei , Tan Xiang , Chen Mingwu , Peng Huajian , Wang Yongyong 
Published: October 2024

BackgroundAlthough mediastinal drainage may lower the risk of anastomotic leakage, the incident rate of anastomotic leakage is still high. The current study aimed to compare the effects of mediastinal drainage combined with upper mediastinal re-tunneling with mediastinal drainage only on anastomotic leakage after McKeown esophagectomy for esophageal cancer.MethodsFrom October 2018 to March 2021, 52 patients diagnosed as esophageal carcinoma were included in the study. 21 patients received mediastinal drainage combined with upper mediastinal re-tunneling (re-tunneling group) and 31 received mediastinal drainage only (standard group) after McKeown esophagectomy. The incidence rate of anastomotic leakage, mediastinal infection, chylothorax, thoracic infection, the peak value of leukocyte count and the mortality related to anastomotic leakage were compared between the two groups.ResultsOne (4.8%) patient in the re-tunneling group developed anastomotic leakage, and no patient experienced mediastinal infection or thoracic infection. Four (12.9%) patients in the standard group developed anastomotic leakage, and all these patients experienced mediastinal infection and thoracic infection (p &lt; 0.05). The drainage volumes of patients in the re-tunneling group and the standard group were (170 ± 60) ml and (155 ± 45) ml, respectively, with no significant difference between the two groups (p &gt; 0.05). The peak values of leukocyte count and temperature in the re-tunneling group were (14.28 ± 1.12) × 109/L and (38.6 ± 1.1) °C, both lower than that of the standard group[ (16.48 ± 1.15) × 109/L and (38.9 ± 1.2) °C, respectively]. But the difference was not statistically significant (p &gt; 0.05). No anastomotic leakage related death occurred in both groups.ConclusionMediastinal drainage combined with upper mediastinal re-tunneling after McKeown esophagectomy for esophageal cancer may decrease the risk of anastomotic leakage, mediastinal and thoracic infection, reduce the inflammatory response of patients, but did not increase the mortality related to anastomotic leakage.Trial registrationThe study was retrospectively registered.