bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning charge carrier transport and optical birefringence in liquid-crystalline thin films: A new design space for organic light-emitting diodes
Authors: Keum Chang-Min , Liu Shiyi , Al-Shadeedi Akram , Kaphle Vikash , Callens Michiel Koen , Han Lu , Neyts Kristiaan , Zhao Hongping , Gather Malte C. , Bunge Scott D. , Twieg Robert J. , Jakli Antal , Lüssem Björn 
Published: January 2018

AbstractLiquid-crystalline organic semiconductors exhibit unique properties that make them highly interesting for organic optoelectronic applications. Their optical and electrical anisotropies and the possibility to control the alignment of the liquid-crystalline semiconductor allow not only to optimize charge carrier transport, but to tune the optical property of organic thin-film devices as well. In this study, the molecular orientation in a liquid-crystalline semiconductor film is tuned by a novel blading process as well as by different annealing protocols. The altered alignment is verified by cross-polarized optical microscopy and spectroscopic ellipsometry. It is shown that a change in alignment of the liquid-crystalline semiconductor improves charge transport in single charge carrier devices profoundly. Comparing the current-voltage characteristics of single charge carrier devices with simulations shows an excellent agreement and from this an in-depth understanding of single charge carrier transport in two-terminal devices is obtained. Finally, p-i-n type organic light-emitting diodes (OLEDs) compatible with vacuum processing techniques used in state-of-the-art OLEDs are demonstrated employing liquid-crystalline host matrix in the emission layer.
Ultrafast consolidation of bulk nanocrystalline titanium alloy through ultrasonic vibration
Authors: Chen P. , Liao W. B. , Liu L. H. , Luo F. , Wu X. Y. , Li P. J. , Yang C. , Yan M. , Liu Y. , Zhang L. C. , Liu Z. Y. 
Published: January 2018

AbstractNanocrystalline (NC) materials have fascinating physical and chemical properties, thereby they exhibit great prospects in academic and industrial fields. Highly efficient approaches for fabricating bulk NC materials have been pursued extensively over past decades. However, the instability of nanograin, which is sensitive to processing parameters (such as temperature and time), is always a challenging issue to be solved and remains to date. Herein, we report an ultrafast nanostructuring strategy, namely ultrasonic vibration consolidation (UVC). The strategy utilizes internal friction heat, generated from mutually rubbing between Ti-based metallic glass powders, to heat the glassy alloy rapidly through its supercooled liquid regime, and accelerated viscous flow bonds the powders together. Consequently, bulk NC-Ti alloy with grain size ranging from 10 to 70 nm and nearly full density is consolidated in 2 seconds. The novel consolidation approach proposed here offers a general and highly efficient pathway for manufacturing bulk nanomaterials.
Hyaluronic acid-based nano-sized drug carrier-containing Gellan gum microspheres as potential multifunctional embolic agent
Authors: Hsu Ming Fang , Tyan Yen Sheng , Chien Yu Chen , Lee Ming Wei 
Published: January 2018

AbstractThe purpose of this study was to develop a gellan gum-based multifunctional embolic agent. Calibrated spherical gellan gum and nanoparticle-containing gellan gum microspheres were prepared via water-in oil emulsification method. Self-assembled nanoparticles composed of short-chain hyaluronic acid and polyethylenimine as the doxorubicin carrier were prepared. The short-chain hyaluronic acid/polyethylenimine/ doxorubicin (sHH/PH/Dox) with the mean size was 140 ± 8 nm. To examine sHH/PH/Dox nanoparticle uptake into cells, the results confirmed that sHH/PH nanoparticles as drug carrier can facilitate the transport of doxorubicin into HepG2 liver cancer cells. Subsequently, sHH/PH/Dox merged into the gellan gum (GG) microspheres forming GG/sHH/PH/Dox microsphere. After a drug release experiment lasting 45 days, the amount of released doxorubicin from 285, 388, and 481 μm GG/sHH/PH/Dox microspheres were approximately 4.8, 1.8 and 1.1-fold above the IC50 value of the HepG2 cell. GG/sHH/PH/Dox microspheres were performed in rabbit ear embolization model and ischemic necrosis on ear was visible due to the vascular after 8 days. Regarding the application of this device in the future, we aim to provide better embolization agents for transcatheter arterial chemoembolization (TACE).
Long-Term Maintenance of Human Pluripotent Stem Cells on cRGDfK-Presenting Synthetic Surfaces
Authors: Lambshead Jack W. , Meagher Laurence , Goodwin Jacob , Labonne Tanya , Ng Elizabeth , Elefanty Andrew , Stanley Edouard , O’Brien Carmel M. , Laslett Andrew L. 
Published: January 2018

AbstractSynthetic human pluripotent stem cell (hPSC) culture surfaces with defined physical and chemical properties will facilitate improved research and therapeutic applications of hPSCs. In this study, synthetic surfaces for hPSC culture in E8 medium were produced for screening by modifying two polymer brush coatings [poly(acrylamide-co-acrylic acid) (PAAA) and poly(acrylamide-co-propargyl acrylamide) (PAPA)] to present single peptides. Adhesion of hPSC colonies was more consistently observed on surfaces modified with cRGDfK compared to surfaces modified with other peptide sequences tested. PAPA-coated polystyrene flasks with coupled cRGDfK (cRGDfK-PAPA) were then used for long-term studies of three hPSC lines (H9, hiPS-NHF1.3, Genea-02). Cell lines maintained for ten passages on cRGDfK-PAPA were assessed for colony morphology, proliferation rate, maintenance of OCT4 expression, cell viability at harvest, teratoma formation potential, and global gene expression as assessed by the PluriTest™ assay. cRGDfK-PAPA and control cultures maintained on Geltrex™ produced comparable results in most assays. No karyotypic abnormalities were detected in cultures maintained on cRGDfK-PAPA, while abnormalities were detected in cultures maintained on Geltrex™, StemAdhere™ or Synthemax™. This is the first report of long term maintenance of hPSC cultures on the scalable, stable, and cost-effective cRGDfK-PAPA coating.
Dysfunction of CD19+CD24hiCD27+ B regulatory cells in patients with bullous pemphigoid
Authors: Liu Zhenfeng , Dang Erle , Li Bing , Qiao Hongjiang , Jin Liang , Zhang Jieyu , Wang Gang 
Published: January 2018

AbstractBullous pemphigoid (BP) is an autoimmune blistering skin disease characterized by the production of autoantibodies against the hemidesmosomal protein BP180. B regulatory cells (Bregs) are crucial in maintaining self-tolerance and suppressing autoantibody production. However, it is still unclear whether the dysfunctions of Bregs contributes to the autoantibody production in BP patients. In this study, we found that CD19+CD24hiCD27+Bregs and IL-10+CD19+Bregs were significantly increased in the peripheral blood samples of BP patients compared with that in healthy controls. Moreover, compared to Bregs from healthy individuals, we found that Bregs from BP patients fails to suppress the production of specific anti-BP180 autoantibody when co-cultured with patient-derived PBMCs. Additionally, Bregs from BP patients were defective in suppressing the CD4+T cell proliferation and the cytokines expression (including IFN-γ, TNF-α and IL-4). Notably, we found that patient-derived Bregs produced high level of TNF-α and the TNF inhibitor etanercept could inhibit the autoantibody production in the culture systemin vitro. Our results indicate that Bregs from BP patient appear phenotypically pro-inflammatory by their cytokine profile and are defective in immunosuppressive function, which suggest that Bregs play a pro-inflammatory role rather than a regulatory role in the pathogenesis of BP.
Transcriptome profiling during mangrove viviparity in response to abscisic acid
Authors: Hong Liwei , Su Wenyue , Zhang Yuanye , Ye Congting , Shen Yingjia , Li Qingshun Q. 
Published: January 2018

AbstractMangrove plants adapt to coastal tidal mudflats with specially evolved viviparity seed development. However, very little is known about the genetic and molecular mechanisms of mangrove viviparity. Here, we tested a hypothesis that plant hormone abscisic acid (ABA) plays a significant role in precocious germination of viviparous Kandelia obovata seeds by exogenous applications. Through transcriptome analysis of ABA treated seeds, it was found that ABA repressed mangrove fruit growth and development, and there were thousands of genes differentially expressed. As a result, dynamics of the pathways were dramatically altered. In particular, “Plant hormone signal transduction” and “MAPK signaling pathway” were represented significantly. Among differentially expressed genes, some key genes of ABA signal transduction were induced, while ABA biosynthesis genes were repressed. Take ABI1 and ABI2, key negative regulators in ABA signal pathway, as examples, homologous alignment and a phylogenetic tree in various species showed that ABI1 and ABI2 are highly conserved among various species. The functional similarity of these genes was confirmed by transgenic work in Arabidopsis. Taken together, ABA inhibited mangrove viviparity, but mangroves developed a mechanism to prevent accidently increase of ABA in the harsh environment for maintaining viviparous reproductive strategy.
Procedure optimisation for green synthesis of silver nanoparticles by Taguchi method
Authors: Aghajani Kalaki Zahra , SafaeiJavan Raheleh , Faraji Hossein 
Published: January 2018

This study is dealing with optimisation of the green synthesised silver nanoparticles (AgNPs) using the Taguchi design. Orthogonal array of L9 type was used as an experimental design to detect the optimum conditions for synthesis of AgNPs. AgNPs were synthesised using the extract of Mentha longifolia as a reducing agent. In addition to the colour changes, ultraviolet visible spectroscopy was used to attest the appearance of AgNPs. Meanwhile, yielded AgNPs were characterised by FT‐IR, scanning electron microscopy and dynamic light scattering (DLS) technique. UV–visible spectrophotometer showed absorbance peak at 340 nm. DLS analysis showed that the synthesised AgNPs are 21.1 nm in optimum conditions. The optimised condition for the synthesis of AgNPs revealed that silver nitrate concentration was 10 mM, temperature was 60°C, pH was 9 and plant extract concentration was 3%. The results demonstrated that AgNPs can be synthesised by controlling silver nitrate and plant extract concentration, pH and temperature. The minimum diameter predicted by statistical model was 35 nm while the obtained diameter was 21.1 nm which is very close to the experimental designed measure. This indicates that the statistical predicated proposed by Taguchi was correct.
Modeling climate diversity, tidal dynamics and the fate of volatiles on TRAPPIST-1 planets
Authors: Turbet Martin , Bolmont Emeline , Leconte Jeremy , Forget François , Selsis Franck , Tobie Gabriel , Caldas Anthony , Naar Joseph , Gillon Michaël 
Published: January 2018

TRAPPIST-1 planets are invaluable for the study of comparative planetary science outside our solar system and possibly habitability. Both transit timing variations (TTV) of the planets and the compact, resonant architecture of the system suggest that TRAPPIST-1 planets could be endowed with various volatiles today. First, we derived from N-body simulations possible planetary evolution scenarios, and show that all the planets are likely in synchronous rotation. We then used a versatile 3D global climate model (GCM) to explore the possible climates of cool planets around cool stars, with a focus on the TRAPPIST-1 system. We investigated the conditions required for cool planets to prevent possible volatile species to be lost permanently by surface condensation, irreversible burying or photochemical destruction. We also explored the resilience of the same volatiles (when in condensed phase) to a runaway greenhouse process. We find that background atmospheres made of N2, CO, or O2are rather resistant to atmospheric collapse. However, even if TRAPPIST-1 planets were able to sustain a thick background atmosphere by surviving early X/EUV radiation and stellar wind atmospheric erosion, it is difficult for them to accumulate significant greenhouse gases like CO2, CH4, or NH3. CO2can easily condense on the permanent nightside, forming CO2ice glaciers that would flow toward the substellar region. A complete CO2ice surface cover is theoretically possible on TRAPPIST-1g and h only, but CO2ices should be gravitationally unstable and get buried beneath the water ice shell in geologically short timescales. Given TRAPPIST-1 planets large EUV irradiation (at least ~103 × Titan’s flux), CH4and NH3are photodissociated rapidly and are thus hard to accumulate in the atmosphere. Photochemical hazes could then sedimentate and form a surface layer of tholins that would progressively thicken over the age of the TRAPPIST-1 system. Regarding habitability, we confirm that few bars of CO2would suffice to warm the surface of TRAPPIST-1f and g above the melting point of water. We also show that TRAPPIST-1e is a remarkable candidate for surface habitability. If the planet is today synchronous and abundant in water, then it should very likely sustain surface liquid water at least in the substellar region, whatever the atmosphere considered.
Gamma-ray emission from internal shocks in novae
Authors: Martin P. , Dubus G. , Jean P. , Tatischeff V. , Dosne C. 
Published: January 2018

Context. Gamma-ray emission at energies ≥100 MeV has been detected from nine novae using the Fermi Large Area Telescope (LAT), and can be explained by particle acceleration at shocks in these systems. Eight out of these nine objects are classical novae in which interaction of the ejecta with a tenuous circumbinary material is not expected to generate detectable gamma-ray emission.
Aim. We examine whether particle acceleration at internal shocks can account for the gamma-ray emission from these novae. The shocks result from the interaction of a fast wind radiatively-driven by nuclear burning on the white dwarf with material ejected in the initial runaway stage of the nova outburst.
Methods. We present a one-dimensional model for the dynamics of a forward and reverse shock system in a nova ejecta, and for the associated time-dependent particle acceleration and high-energy gamma-ray emission. Non-thermal proton and electron spectra are calculated by solving a time-dependent transport equation for particle injection, acceleration, losses, and escape from the shock region. The predicted emission is compared to LAT observations of V407 Cyg, V1324 Sco, V959 Mon, V339 Del, V1369 Cen, and V5668 Sgr.
Results. The ≥100 MeV gamma-ray emission arises predominantly from particles accelerated up to ~100 GeV at the reverse shock and undergoing hadronic interactions in the dense cooling layer downstream of the shock. The emission rises within days after the onset of the wind, quickly reaches a maximum, and its subsequent decrease reflects mostly the time evolution of the wind properties. Comparison to gamma-ray data points to a typical scenario where an ejecta of mass 10−5–10−4 M⊙ expands in a homologous way with a maximum velocity of 1000–2000 km s−1, followed within a day by a wind with a velocity <2000 km s−1 and a mass-loss rate of 10−4–10−3 M⊙ yr−1 declining over a time scale of a few days. Because of the large uncertainties in the measurements, many parameters of the problem are degenerate and/or poorly constrained except for the wind velocity, the relatively low values of which result in the majority of best-fit models having gamma-ray spectra with a high-energy turnover below ~10 GeV. Our typical model is able to account for the main features in the observations of the recent gamma-ray nova ASASSN-16ma.
Conclusions. The internal shock model can account for the gamma-ray emission of the novae detected by Fermi LAT. Gamma-ray observations hold potential for probing the mechanism of mass ejection in novae, but should be combined to diagnostics of the thermal emission at lower energies to be more constraining.
Flare particle acceleration in the interaction of twisted coronal flux ropes
Authors: Threlfall J. , Hood A. W. , Browning P. K. 
Published: January 2018

Aim. The aim of this work is to investigate and characterise non-thermal particle behaviour in a three-dimensional (3D) magnetohydrodynamical (MHD) model of unstable multi-threaded flaring coronal loops.Methods. We have used a numerical scheme which solves the relativistic guiding centre approximation to study the motion of electrons and protons. The scheme uses snapshots from high resolution numerical MHD simulations of coronal loops containing two threads, where a single thread becomes unstable and (in one case) destabilises and merges with an additional thread.Results. The particle responses to the reconnection and fragmentation in MHD simulations of two loop threads are examined in detail. We illustrate the role played by uniform background resistivity and distinguish this from the role of anomalous resistivity using orbits in an MHD simulation where only one thread becomes unstable without destabilising further loop threads. We examine the (scalable) orbit energy gains and final positions recovered at different stages of a second MHD simulation wherein a secondary loop thread is destabilised by (and merges with) the first thread. We compare these results with other theoretical particle acceleration models in the context of observed energetic particle populations during solar flares.
Convective blueshifts in the solar atmosphere
Authors: Löhner-Böttcher J. , Schmidt W. , Stief F. , Steinmetz T. , Holzwarth R. 
Published: January 2018

Context. The solar convection manifests as granulation and intergranulation at the solar surface. In the photosphere, convective motions induce differential Doppler shifts to spectral lines. The observed convective blueshift varies across the solar disk.
Aim. We focus on the impact of solar convection on the atmosphere and aim to resolve its velocity stratification in the photosphere.
Methods. We performed high-resolution spectroscopic observations of the solar spectrum in the 6302 Å range with the Laser Absolute Reference Spectrograph at the Vacuum Tower Telescope. A laser frequency comb enabled the calibration of the spectra to an absolute wavelength scale with an accuracy of 1 m s−1. We systematically scanned the quiet Sun from the disk center to the limb at ten selected heliocentric positions. The analysis included 99 time sequences of up to 20 min in length. By means of ephemeris and reference corrections, we translated wavelength shifts into absolute line-of-sight velocities. A bisector analysis on the line profiles yielded the shapes and convective shifts of seven photospheric lines.
Results. At the disk center, the bisector profiles of the iron lines feature a pronounced C-shape with maximum convective blueshifts of up to −450 m s−1 in the spectral line wings. Toward the solar limb, the bisectors change into a “\”-shape with a saturation in the line core at a redshift of +100 m s−1. The center-to-limb variation of the line core velocities shows a slight increase in blueshift when departing the disk center for larger heliocentric angles. This increase in blueshift is more pronounced for the magnetically less active meridian than for the equator. Toward the solar limb, the blueshift decreases and can turn into a redshift. In general, weaker lines exhibit stronger blueshifts.
Conclusions. Best spectroscopic measurements enabled the accurate determination of absolute convective shifts in the solar photosphere. We convolved the results to lower spectral resolution to permit a comparison with observations from other instruments.
The STAGGER-grid: A grid of 3D stellar atmosphere models
Authors: Chiavassa A. , Casagrande L. , Collet R. , Magic Z. , Bigot L. , Thévenin F. , Asplund M. 
Published: January 2018

Context. The surface structures and dynamics of cool stars are characterised by the presence of convective motions and turbulent flows which shape the emergent spectrum.
Aims. We used realistic three-dimensional (3D) radiative hydrodynamical simulations from the STAGGER-grid to calculate synthetic spectra with the radiative transfer code OPTIM3D for stars with different stellar parameters to predict photometric colours and convective velocity shifts.
Methods. We calculated spectra from 1000 to 200 000 Å with a constant resolving power of λ∕Δλ = 20 000 and from 8470 and 8710 Å (Gaia Radial Velocity Spectrometer – RVS – spectral range) with a constant resolving power of λ∕Δλ = 300 000.
Results. We used synthetic spectra to compute theoretical colours in the Johnson-Cousins UBV (RI)C, SDSS, 2MASS, Gaia, SkyMapper, Strömgren systems, and HST-WFC3. Our synthetic magnitudes are compared with those obtained using 1D hydrostatic models. We showed that 1D versus 3D differences are limited to a small percent except for the narrow filters that span the optical and UV region of the spectrum. In addition, we derived the effect of the convective velocity fields on selected Fe I lines. We found the overall convective shift for 3D simulations with respect to the reference 1D hydrostatic models, revealing line shifts of between −0.235 and +0.361 km s−1. We showed a net correlation of the convective shifts with the effective temperature: lower effective temperatures denote redshifts and higher effective temperatures denote blueshifts. We conclude that the extraction of accurate radial velocities from RVS spectra need an appropriate wavelength correction from convection shifts.
Conclusions. The use of realistic 3D hydrodynamical stellar atmosphere simulations has a small but significant impact on the predicted photometry compared with classical 1D hydrostatic models for late-type stars. We make all the spectra publicly available for the community through the POLLUX database.