bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence and extent of right-to-left shunt on contrast-enhanced transcranial Doppler in Chinese patients with migraine in a multicentre case-control study
Authors: Wang Si-Bo , Liu Kang-Ding , Yang Yi , Li Ya-Jie , Hu Ming-Yi , Lin Pan , Guo Rong , Tian Qian , You Yong , Cui Ying-Hua , Zhang Guan-Ling , Dong Zhao , Gao Yong-Sheng , Xing Ying-Qi 
Published: May 2017

Background The association between RLS and migraine is still debated. The aim of this study is to investigate the prevalence and grade of RLS in Chinese patients with migraine and to evaluate the relationship between RLS and migraine. Methods A multi-center case-control study of contrast-enhanced transcranial Doppler was conducted in 931 consecutive patients with migraine (240 of 931 had migraine with aura and 691 of 931 were in the migraine without aura group) and 282 were healthy adults. Clinical trial no. NCT02425696. Results The prevalence of RLS was 63.8% and 39.9% in the migraine with aura group (MA+) and migraine without aura group (MA−), respectively, significantly higher than that of the healthy group (29.4%, p < 0.001; p < 0.001). The positive rate of large RLS in the MA+ group and MA− group was 32.1% and 16.5%, respectively, significantly higher than healthy group (6.4%, p < 0.001; p < 0.001). There was no difference among groups in terms of positive rate of permanent RLS ( p = 0.704). Conclusion This multi-centre case-control study suggested that there is an association between RLS and migraine with and without aura, especially when the shunt is large.
Discovery of small molecule inhibitors of the Wnt/β-catenin signaling pathway by targeting β-catenin/Tcf4 interactions
Authors: Yan Maocai , Li Guanqun , An Jing 
Published: May 2017

The Wnt/β-catenin signaling pathway typically shows aberrant activation in various cancer cells, especially colorectal cancer cells. This signaling pathway regulates the expression of a variety of tumor-related proteins, including c-myc and cyclin D1, and plays essential roles in tumorigenesis and in the development of many cancers. Small molecules that block the interactions between β-catenin and Tcf4, a downstream stage of activation of the Wnt/β-catenin signaling pathway, could efficiently cut off this signal transduction and thereby act as a novel class of anticancer drugs. This paper reviews the currently reported inhibitors that target β-catenin/Tcf4 interactions, focusing on the discovery approaches taken in the design of these inhibitors and their bioactivities. A brief perspective is then shared on the future discovery and development of this class of inhibitors.Impact statementThis mini-review summarized the current knowledge of inhibitors of interactions of beta-catenin/Tcf4 published to date according to their discovery approaches, and discussed their in vitro and in vivo activities, selectivities, and pharmacokinetic properties. Several reviews presently available now in this field describe modulators of the Wnt/beta-catenin pathway, but are generally focused on the bioactivities of these inhibitors. By contrast, this review focused on the drug discovery approaches taken in identifying these types of inhibitors and provided our perspective on further strategies for future drug discoveries. This review also integrated many recently published and important works on highly selective inhibitors as well as rational drug design. We believe that the findings and strategies summarized in this review have broad implications and will be of interest throughout the biochemical and pharmaceutical research community.
Association between suicidal symptoms and repeat suicidal behaviour within a sample of hospital-treated suicide attempters
Authors: de Beurs Derek P. , van Borkulo Claudia D. , O'Connor Rory C. 
Published: May 2017

BackgroundSuicidal behaviour is the end result of the complex relation between many factors which are biological, psychological and environmental in nature. Network analysis is a novel method that may help us better understand the complex association between different factors.AimsTo examine the relationship between suicidal symptoms as assessed by the Beck Scale for Suicide Ideation and future suicidal behaviour in patients admitted to hospital following a suicide attempt, using network analysis.MethodSecondary analysis was conducted on previously collected data from a sample of 366 patients who were admitted to a Scottish hospital following a suicide attempt. Network models were estimated to visualise and test the association between baseline symptom network structure and suicidal behaviour at 15-month follow-up.ResultsNetwork analysis showed that the desire for an active attempt was found to be the most central, strongly related suicide symptom. Of the 19 suicide symptoms that were assessed at baseline, 10 symptoms were directly related to repeat suicidal behaviour. When comparing baseline network structure of repeaters (n=94) with the network of non-repeaters (n=272), no significant differences were found.ConclusionsNetwork analysis can help us better understand suicidal behaviour by visualising the complex relation between relevant symptoms and by indicating which symptoms are most central within the network. These insights have theoretical implications as well as informing the assessment and treatment of suicidal behaviour.
Cardiac autonomic changes elicited by energy-based healing modality: pilot study
Authors: Imperato Lenita M , Quitério Robison J , Canella Glauco C , Garner David M , Raimundo Rodrigo D , de Abreu Luiz Carlos , Valenti Vitor E 
Published: May 2017

Energy-based healing techniques have rarely been explored in current complementary therapies literature. This therapy is appropriate for cardiac nursing and can be implemented as part of nursing care. The authors investigated the acute effects of a standardised energy-based healing technique on cardiac autonomic regulation. Method: This study was conducted on 18 healthy students (15 female, three male), all non-smokers aged 18–35 years. Heart rate variability (HRV) was analysed 10 minutes before and 10 minutes after the energy-based healing technique was carried out. Geometric, time and frequency domain indices of HRV were examined. The subjects were blindfolded and sat at rest for 10 minutes, then received a standardised energy-based healing technique from an experienced male healer; they remained blindfolded and seated for a further 10 minutes. Results: Time and frequency domain indices of HRV were not significantly different before and after the energy-based healing technique. TINN (triangular interpolation histogram of RR intervals) (P=0.04) and RRTri (triangular index) (P=0.02) were increased after the therapy. A Poincaré plot indicated a slight increase in RR intervals dispersion after energy-based healing technique. Conclusion: A standardised energy-based healing technique marginally improved cardiac autonomic function in healthy subjects.
Use of fat transfer to treat a chronic, non-healing, post-radiation ulcer: a case study
Authors: Mohan A. , Singh S. 
Published: May 2017

Objective: Problematic wound healing and ulceration in radiation-damaged tissue is a surgical challenge. Clinical studies have shown that grafting fat tissue in an irradiated area can improve the quality of the skin and has regenerative effects. This case study describes how fat transfer led to the healing of a chronic ulcer resistant to other forms of treatment. Case history: A 67-year-old lady with a chronic, non-healing ulcer in her leg had a squamous cell carcinoma excised, followed by radiotherapy. Despite multiple excisions, the ulcer continued to cause symptoms. Following an initial procedure in which fat was infiltrated around and under the ulcer, the patient underwent a wide local excision and split-thickness skin grafting. Histology demonstrated a post-radiation dermatitis ulcer with no evidence of malignancy. After a period of management with dressings showing a reduction in ulcer size, more fat was infiltrated around the lesion. Two months later, the ulcer had fully healed and has not recurred. Conclusion: The use of adipose-derived stem cells to heal wounds in irradiated tissue has been the focus of research for some time. This case highlights the potential of adipose tissue to improve damaged skin. Its use could negate the need for complex surgical procedures.
Rozvoj profesního vidění studentů oboru Učitelství pro mateřské školy
Authors: Syslová Zora 
Published: May 2017

Abstrakt: Předložená studie přináší do odborného diskurzu pohled na rozvoj profesního vidění jako jedné z důležitých dimenzí profesionality učitelů mateřských škol. Jejím cílem je popsat povahu profesního vidění studentů učitelství pro mateřské školy a změn, které nastaly po systematické reflexi videonahrávek reálného vzdělávání v mateřské škole. Respondenty výzkumu se stalo 18 studentek oboru Učitelství mateřské školy Pedagogické fakulty Masarykovy univerzity. Data byla sbírána na začátku semestru, ve kterém probíhala intenzivní práce s videonahrávkami a v následujícím semestru. Písemné komentáře studentek byly analyzovány pomocí dvou kategoriálních systémů. Jeden zachytil zaměření jejich pozornosti a druhý, jak o viděném uvažují. Rozdílnosti v zaměření pozornosti a zastoupení myšlenkových operací mezi dvěma měřeními byla ověřena chí-kvadrát testem nezávislosti.Výsledky naznačují, že pozornost studentů je zaměřena především na učitele a v jejich komentářích převažuje popis. Po systematické práci s analýzami videonahrávek došlo ke kvalitativním i kvantitativním změnám, což naznačuje posun v jejich profesním vidění a způsobu přemýšlení o vzdělávací realitě. Klíčová slova: pregraduální vzdělávání, profesní vidění, předškolní vzdělávání, student, videonahrávky, zaměření pozornosti.
The influence of soil salinity on volatile organic compounds emission and photosynthetic parameters of Solanum lycopersicum L. varieties
Authors: Tomescu Daniel , Şumălan Radu , Copolovici Lucian , Copolovici Dana 
Published: May 2017

AbstractSoil salinity is one of the best known stress factors of plants that can lead to crop yield reduction. Therefore, it is important to identify new tolerance varieties of plants that can grow on saline soils. We have studied the influence of salt on five different tomato varieties from the Western region of Romania and compared them with a commercial hybrid and found that one of them (Rudna) is a very salt-tolerant variety (up to 200 mM NaCl). The assimilation rates and stomata conductance of water vapour are affected by salinity but some of the local varieties of tomato exhibit quite good tolerance. We found that all plants under salinity stress emit (Z)-3-hexenol (a C6, green leaf volatile) and the emission of all terpenes increased in proportion to the salt concentration. The emission of three terpenes, (Z)-beta-ocimene. 2-carene and beta-phellandrene, have been quantitatively correlated with salt concentration.
Product Portfolio Management Best Practices For New Product Development: A Review Of Models
Authors: Doorasamy Mishelle 
Published: May 2017

Abstract
The survival of any industrial organization depends on whether producing goods or services hinge on how innovative they have become in managing their product portfolio to craft new products that changes with the ever-changing tastes and needs of their customers. This study delves in to the models and theories that drive product portfolio management practices in a way that they support the successes of new product development. Our review is based on selected studies at the frontier of product management, summarized, and compared based on authors experiences, subsisting models, and theories with the results purely based on qualitative rather than quantitative approaches. The essence is to explore possible new theory or model in this field of research.
A Study on Improving the Effectiveness of a Manufacturing Company in the Context of Knowledge Management – Research Results
Authors: Patalas-Maliszewska Justyna , Kłos Sławomir 
Published: May 2017

AbstractThis paper presents the relationship between the various kinds of knowledge that should be acquired, created, accumulated, shared, and transferred within a manufacturing company in order to improve organizational effectiveness. It is based on the data obtained from 85 Polish and German manufacturing companies from the cross-border cooperation region of Lubuskie/Poland - Brandenburg/ Germany. This is followed by a discussion of the results of empirical studies and of the supporting literature.
Philippine Literature in Spanish: Canon Away from Canon
Authors: Ortuño Casanova Rocío 
Published: May 2017

AbstractWhy does everyone know Claro M. Recto’s name in the Philippines but almost nobody has ever read his works? Following Pascale Casanova as well as some postulates by Pierre Bourdieu and Itamar Even-Zohar, the article outlines the complex linguistic reality in the Philippines at the beginning of the 20th century and traces the origins of the current literary canon of Philippine literature, as well as its contemporary position both nationally and internationally. It also discusses how markers of literary prestige were supplanted by markers of political and patriotic prestige, thereby creating a literary canon based on an author’s contribution to the creation of a suitable ‘Philippine national identity’.
Theatrical Entrepôts: Mediating Locality on the Bandmann Circuit
Authors: Balme Christopher 
Published: May 2017

AbstractThe Bandmann theatrical circuit operated between the 1890 s and the 1920 s and comprised roughly two dozen towns and cities stretching from Gibraltar to Yokohama that the companies visited on a regular basis. This paper will examine a selected number of these localities both in terms of their cultural specificities but also in respect to their connectivity. The concept of theatrical entrepôt proposed here proceeds from an understanding of locality that is predicated on the passage and the conduit of goods (in this case theatrical). It employs terms from actor-network-theory that conceptualize locality not just in splendid isolation but as a set of interconnected nodes. Four entrepôts will be analysed in detail: Malta, Bombay, Calcutta and Singapore. In the case of Bombay and Calcutta, Bandmann’s theatre-building activities will be examined as a means to achieve a greater degree of locality. The ports of call such as Malta and Singapore were important as naval bases but in the case of Singapore as a multicultural entrepôt which enabled the distribution of opium grown in India and designed for export to China and East Asia.
Comparative evaluation of hypoglycemic and hypolipidemic activity of various extract of Anogeissus latifolia bark in streptozotocin-induced diabetic rats
Authors: Ramachandran Subramaniam , Faisal Thekkin Kattil , Anjumary Jose , Rajasekaran Aiyalu , Asokkumar Kuppusamy , Annadurai Kuppusamy , Arivukkarasu Ramasamy , Sharma Rajeev Kumar , Shankar Madhira Bhavani 
Published: May 2017

Abstract

Background

Anogeissus latifolia Wall. (A. latifolia) bark has been traditionally used in the treatment of various diseases which includes diabetes and general debility. The present study was aimed to investigate the comparative hypoglycemic and hypolipidemic activity of various extracts of A. latifolia bark in streptozotocin-induced type 1 diabetic rats.

Methods
Acute toxicity was carried out at 2 g/kg dose of petroleum ether extract of A. latifolia bark (PEALB), chloroform extract of A. latifolia bark (CEALB) and methanol extract of A. latifolia bark (MEALB) in rats. Diabetes was induced by streptozotocin (STZ, 60 mg/kg, i.p.) and it was confirmed at 72 h. Diabetic rats received above extracts at 100 and 200 mg/kg doses for 28 days. Body weight and blood glucose level were determined at every week after the treatment schedule. Serum biochemical parameters and lipid profile levels were estimated at the end of the study.

Results
PEALB, CEALB and MEALB were non-toxic and no death was observed at 2 g/kg dose. Administration of MEALB at 100 and 200 mg/kg showed significant (p< 0.01, p< 0.05) improvement in body weight and reduction in blood glucose at third and fourth week of treatment. Altered serum biochemical parameters and lipid profiles level were brought to near normal level significantly (p<0.001) compared to diabetic control rats after the administration of both doses of MEALB. However, PEALB and CEALB did not exhibit significant hypoglycemic and hypolipidemic activity.

Conclusions
Our findings revealed that long-term (28 days) treatment of MEALB possesses significant hypoglycemic and hypolipidemic activity compared to PEALB and CEALB in type 1 diabetic rats and given evidence to the traditional use of A. latifolia bark in diabetes.
Contracting Out of the Provision of Welfare Services to Private Actors and Liability Issues
Authors: Ulfbeck Vibe , Andrecka Marta 
Published: May 2017

AbstractThe article discusses liability issues related to the contracting out of welfare services. It focuses on the possible liability of the private actor and of the public entity towards the individual (the citizen) for non-performance or mal-performance of the welfare service. It is argued that since there is no contract between the individual and the private service provider there may be several obstacles to a claim against the private service provider based on contract. At the same time it is a general tort law principle that there is no vicarious liability for independent contractors, making it difficult also to succeed with a claim against the public entity based on tort law. Thus, a liability gap seems to exist. However, the article demonstrates that there are signs in different jurisdictions that solutions are being found in case law to this problem allowing to some extent for the imposition of some kind of vicarious liability on the public entity. Four different models are identified. The reasoning behind these models varies but they all have in common that the public law nature of the service that has been outsourced somehow plays a role.
Reason, Culture and Education
Authors: Brock Steen 
Published: May 2017

AbstractOn the basis of first a critique of Bakhurst view on (respectively) the notion of “the space of reasons”, “second nature” and “formation”, and second, Wittgenstein’s view on culture and education, I go into details about how one might apply Wittgensteinian thought within a new assessment of education, seen as a matter of “taking steps” within a toolbox or platform generated by forms of teaching. Invoking Kierkegaard, I conclude that the educated person does not incarnate “an absolute difference” in relation to non-educated beings. The educated person is instead the embodiment of “a difference”, that is, of an individuality. Education is not taking the individual from A (barbarian state) to B (better having than not having); it is providing the platform for the possibility of the actuality of somebody’s “being at B”. The argument is: Teaching gives different individuals the same such platform but each person appropriates the platform differently to the effect that the actuality of being “at B” is different from person to person.
Zum Verhältnis von Buddhismus und Nationalsozialismus
Authors: Zotz Volker 
Published: May 2017

Zusammenfassung
Gab es zwischen 1933 und 1945 unter den Ideologen der NS-Bewegung unterschiedliche Positionen zum Buddhismus, bestand bei deutschen Buddhisten eine überwiegend zustimmende Einstellung zum Nationalsozialismus. Im Umkreis Himmlers wollte der Indologe Walther Wüst zwischen dem Buddha und Adolf Hitler als bedeutender Arier Parallelen feststellen. Auch fand die Idee der Wiedergeburt Zustimmung. Alfred Rosenberg und Alfred Grunsky werteten den Buddha als arischen Mann der Tat. Die der NSDAP angehörenden Philosophen August Faust, Eugen Herrigel und Karlfried Graf Dürckheim versprachen sich Impulse vom Zen-Buddhismus. Dagegen lehnten Ernst Bergmann und Ernst Krieck den Buddhismus ab und warnten vor asiatischen Einflüssen in Europa als einer Bedrohung der Lebensbejahung des westlichen Menschen. Die Exponenten des deutschen Buddhisten hatten zumeist positive Einstellungen zum Nationalsozialismus. Man setzte einem semitischen Christentum den von einem Arier gegründeten Buddhismus entgegen.
Disruption of the Right Temporoparietal Junction Impairs Probabilistic Belief Updating
Authors: Mengotti Paola , Dombert Pascasie L. , Fink Gereon R. , Vossel Simone 
Published: May 2017

Generating and updating probabilistic models of the environment is a fundamental modus operandi of the human brain. Although crucial for various cognitive functions, the neural mechanisms of these inference processes remain to be elucidated. Here, we show the causal involvement of the right temporoparietal junction (rTPJ) in updating probabilistic beliefs and we provide new insights into the chronometry of the process by combining online transcranial magnetic stimulation (TMS) with computational modeling of behavioral responses. Female and male participants performed a modified location-cueing paradigm, where false information about the percentage of cue validity (%CV) was provided in half of the experimental blocks to prompt updating of prior expectations. Online double-pulse TMS over rTPJ 300 ms (but not 50 ms) after target appearance selectively decreased participants' updating of false prior beliefs concerning %CV, reflected in a decreased learning rate of a Rescorla–Wagner model. Online TMS over rTPJ also impacted on participants' explicit beliefs, causing them to overestimate %CV. These results confirm the involvement of rTPJ in updating of probabilistic beliefs, thereby advancing our understanding of this area's function during cognitive processing.SIGNIFICANCE STATEMENTContemporary views propose that the brain maintains probabilistic models of the world to minimize surprise about sensory inputs. Here, we provide evidence that the right temporoparietal junction (rTPJ) is causally involved in this process. Because neuroimaging has suggested that rTPJ is implicated in divergent cognitive domains, the demonstration of an involvement in updating internal models provides a novel unifying explanation for these findings. We used computational modeling to characterize how participants change their beliefs after new observations. By interfering with rTPJ activity through online transcranial magnetic stimulation, we showed that participants were less able to update prior beliefs with TMS delivered at 300 ms after target onset.