bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anger Self-Management Training for Chronic Moderate to Severe Traumatic Brain Injury: Results of a Randomized Controlled Trial
Authors: Hart Tessa , Brockway Jo Ann , Maiuro Roland D. , Vaccaro Monica , Fann Jesse R. , Mellick David , Harrison-Felix Cindy , Barber Jason , Temkin Nancy 
Published: May 2017

Objective:
To test efficacy of 8-session, 1:1 treatment, anger self-management training (ASMT), for chronic moderate to severe traumatic brain injury (TBI).

Setting:
Three US outpatient treatment facilities.

Participants:
Ninety people with TBI and elevated self-reported anger; 76 significant others (SOs) provided collateral data.

Design:
Multicenter randomized controlled trial with 2:1 randomization to ASMT or structurally equivalent comparison treatment, personal readjustment and education (PRE). Primary outcome assessment 1 week posttreatment; 8-week follow-up.

Primary Outcome:
Response to treatment defined as 1 or more standard deviation change in self-reported anger.

Secondary Outcomes:
SO-rated anger, emotional and behavioral status, satisfaction with life, timing of treatment response, participant and SO-rated global change, and treatment satisfaction.

Main Measures:
State-Trait Anger Expression Inventory-Revised Trait Anger (TA) and Anger Expression-Out (AX-O) subscales; Brief Anger-Aggression Questionnaire (BAAQ); Likert-type ratings of treatment satisfaction, global changes in anger and well-being.

Results:
After treatment, ASMT response rate (68%) exceeded that of PRE (47%) on TA but not AX-O or BAAQ; this finding persisted at 8-week follow-up. No significant between-group differences in SO-reported response rates, emotional/behavioral status, or life satisfaction. ASMT participants were more satisfied with treatment and rated global change in anger as significantly better; SO ratings of global change in both anger and well-being were superior for ASMT.

Conclusion:
ASMT was efficacious and persistent for some aspects of problematic anger. More research is needed to determine optimal dose and essential ingredients of behavioral treatment for anger after TBI.
Incidence of Neurological Disorders Among HIV-Infected Individuals With Universal Health Care in Taiwan From 2000 to 2010
Authors: Tsai Yi-Tseng , Chen Yen-Chin , Hsieh Chen-Yang , Ko Wen-Chien , Ko Nai-Ying 
Published: May 2017

Objective:
To determine the incidence of and factors associated with neurological disorders in a large Taiwanese cohort of HIV-infected persons with free access to highly active antiretroviral therapy (HAART).

Design:
A retrospective population-based cohort study was conducted using the National Health Insurance Research Database for the years 2000–2010.

Methods:
We identified 13,316 HIV-positive persons from 2000 through 2010. We used direct standardization to calculate age-adjusted and sex-adjusted incidence rates based on the 2000 World Health Organization world standard population. Factors associated with neurological disorders were analyzed using a Cox proportional hazards model.

Results:
The standardized incidence of neurological disorders among HIV-infected persons increased from 22.16 per 1000 person-years in 2000 to 25.23 per 1000 person-years in 2010. Cognitive disorders increased significantly from 0.36 per 1000 person-years in 2001 to 7.44 per 1000 person-years in 2010 (trend P < 0.001). The rate of neurological disorders increased with age ≥55 years [adjusted hazard ratios (AHRs) 2.54, 95% confidence interval (CI): 1.89 to 3.40], hypertension (AHR 1.41, 95% CI: 1.12 to 1.76), substance abuse (AHR 1.65, 95% CI: 1.36 to 2.02), opportunistic infection (AHR 1.76, 95% CI: 1.47 to 2.11), syphilis (AHR 1.27, 95% CI: 1.10 to 1.47), and emergency department visits >5 (AHR 2.41, 95% CI: 1.96 to 2.97). The incidence of neurological disorders was negatively associated with adherence to HAART (adherence ≥85% AHR: 0.79, 95% CI: 0.64 to 0.97).

Conclusions:
The rising incidence of cognitive disorders among HIV-positive persons highlights the need to provide routine neurological evaluations at clinical visits. Receiving HAART with adherence ≥85% contributes to a reduced risk of neurological disorders.
Defining a Cutoff for Atazanavir in Hair Samples Associated With Virological Failure Among Adolescents Failing Second-Line Antiretroviral Treatment
Authors: Chawana Tariro D. , Gandhi Monica , Nathoo Kusum , Ngara Bernard , Louie Alexander , Horng Howard , Katzenstein David , Metcalfe John , Nhachi Charles F. B. ,   Adolescent Treatment Failure (ATF) study team
Published: May 2017

Background:
Adequate antiretroviral exposure is crucial to virological suppression. We assessed the relationship between atazanavir hair levels with self-reported adherence, virological outcomes, and the effect of a home-based adherence intervention in HIV-infected adolescents failing second-line antiretroviral treatment in Zimbabwe.

Methods:
HIV-infected adolescents on atazanavir/ritonavir-based second-line treatment for ≥6 months with viral load (VL) >1000 copies/mL were randomized to either standard care (control) or standard care plus modified directly administered antiretroviral therapy (intervention). Questionnaires were administered; VL and hair samples were collected at baseline and after 90 days in each group. Viral suppression was defined as <1000 copies/mL after follow-up.

Results:
Fifty adolescents (10–18 years) were enrolled; 23 (46%) were randomized to intervention and 27 (54%) to control. Atazanavir hair concentration <2.35 ng/mg (lower interquartile range for those with virological suppression) defined a cutoff below which most participants experienced virological failure. Male sex (P = 0.03), virological suppression at follow-up (P = 0.013), greater reduction in VL (P = 0.006), and change in average self-reported adherence over the previous month (P = 0.031) were associated with adequate (>2.35 ng/mg) hair concentrations. Participants with virological failure were more likely to have suboptimal atazanavir hair concentrations (RR = 7.2, 95% CI: 1 to 51, P = 0.049). There were no differences in atazanavir hair concentration between the arms after follow-up.

Conclusions:
A threshold of atazanavir concentrations in hair (2.35 ng/mg), above which virological suppression was likely, was defined for adolescents failing second-line atazanavir/ritonavir-based ART in Zimbabwe. Male sex and better self-reported adherence were associated with adequate atazanavir hair concentrations. Antiretroviral hair concentrations may serve as a useful clinical tool among adolescents.
Dynein pulling forces on ruptured nuclei counteract lamin-mediated nuclear envelope repair mechanisms in vivo
Authors: Penfield Lauren , Wysolmerski Brian , Farhadifar Reza , Martinez Michael , Biggs Ronald , Wu Hai-Yin , Mauro Michael , Broberg Curtis , Needleman Daniel , Bahmanyar Shirin 
Published: May 2017

AbstractRecent work done exclusively in tissue culture cells revealed that the nuclear envelope (NE) undergoes ruptures leading to transient mixing of nuclear and cytoplasmic components. The duration of transient NE ruptures depends on lamins, however the underlying mechanisms and the relevance toin vivoevents is not known. Here, we useC. elegansembryos to show that dynein forces that position nuclei increase the severity of lamin-induced NE rupturesin vivo. In the absence of dynein forces, lamin prevents nuclear-cytoplasmic mixing caused by NE ruptures. By monitoring the dynamics of NE rupture events, we demonstrate that lamin is required for a distinct phase in NE recovery that restricts nucleocytoplasmic mixing prior to the full restoration of NE rupture sites. We show that laser-induced puncture of the NE recapitulates phenotypes associated with NE recovery in wild type cells. Surprisingly, we find that embryonic lethality does not correlate with the incidence of NE rupture events suggesting that embryos survive transient losses of NE compartmentalization during early embryogenesis. In addition to presenting the first mechanistic analysis of transient NE rupturesin vivo, this work demonstrates that lamin controls the duration of NE ruptures by opposing dynein forces on ruptured nuclei to allow reestablishment of the NE permeability barrier and subsequent restoration of NE rupture sites.
An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program
Authors: Tasseff Ryan , Jensen Holly A. , Congleton Johanna , Dai Wei , Rogers Katharine V. , Sagar Adithya , Bunaciu Rodica P. , Yen Andrew , Varner Jeffrey D. 
Published: May 2017

ABSTRACTIn this study, we present an effective model All-Trans Retinoic Acid (ATRA)-induced differentiation of HL-60 cells. The model describes reinforcing feedback between an ATRA-inducible signalsome complex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation of the mitogen activated protein kinase (MAPK) cascade. We decomposed the effective model into three modules; a signal initiation module that sensed and transformed an ATRA signal into program activation signals; a signal integration module that controlled the expression of upstream transcription factors; and a phenotype module which encoded the expression of functional differentiation markers from the ATRA-inducible transcription factors. We identified an ensemble of effective model parameters using measurements taken from ATRA-induced HL-60 cells. Using these parameters, model analysis predicted that MAPK activation was bistable as a function of ATRA exposure. Conformational experiments supported ATRA-induced bistability. Additionally, the model captured intermediate and phenotypic gene expression data. Knockout analysis suggested Gfi-1 and PPAR$[gamma] were critical to the ATRA-induced differentiation program. These findings, combined with other literature evidence, suggested that reinforcing feedback is central to hyperactive signaling in a diversity of cell fate programs.
Transcranial alternating current stimulation (tACS) mechanisms and protocols
Authors: Tavakoli Amir Vala , Yun Kyongsik 
Published: May 2017

AbstractWhat if you could affect both neuroplasticity and human cognitive performance by parametrically modulating neural oscillations? Ongoing neuronal activity is susceptible to the modulation of synaptic activity and membrane potentials. This susceptibility leverages transcranial alternating current stimulation (tACS) for neuroplastic interventions. Through neuromodulation of phasic, neural activity, tACS presents a powerful tool for investigations of the neural correlates of cognition alongside other forms of transcranial electric stimulation (tES) and noninvasive brain stimulation (NIBS). The rapid pace of development in this area requires clarification of best practices. Here, we briefly introduce tACS dogma and review the most compelling findings from the tACS literature to provide a starting point for the use of tACS under research conditions.
Poor man's two photon imaging: Scanning Laser Upconversion Microscopy
Authors: Sorbello Cecilia , Etchenique Roberto 
Published: May 2017

ABSTRACTTwo photon microscopy is one of the most powerful techniques for optical images. Its deep penetration, low scattering and mainly its sectioning power allows exquisite control on all three axes of 3D samples, both for imaging and actuation. Unfortunately, this technique involves very expensive femtosecond lasers. Upconverting Nanoparticles display multiphoton absorption at low instantaneous power, which can be achieved by means of cheap laser diodes. Scanning Laser Upconversion Microscopy offers the deep penetration and low scattering of NIR excitation together with the sectioning power of multiphoton techniques for under US$ 1000.
A Liquid Chromatography-Mass Spectrometry Method for Screening Disulfide Tethering Fragments
Authors: Hallenbeck Kenneth K , Davies Julia L. , Merron Connie , Ogden Pierce , Sijbesma Eline , Ottmann Christian , Renslo Adam R. , Wilson Christopher , Arkin Michelle R. 
Published: May 2017

AbstractWe report the refinement of a high-throughput, liquid-chromatography/mass spectrometry (LC/MS)-based screening method for the identification of covalent small-molecule binders to proteins. Using a custom library of 1600 disulfide-capped fragments targeting surface cysteine residues, we optimize sample preparation, chromatography, and ionization conditions to maximize the reliability and flexibility of the approach. Data collection at a rate of 90 seconds per sample balances speed and reliability for sustained screening over multiple, diverse projects run over a 24-month period. The method is applicable to protein targets of various classes and a range of molecular masses. Data are processed in a custom pipeline that calculates a % bound value for each compound and detects false-positives by calculating significance of detected masses (‘signal significance’). An example pipeline has been made available through Biovia’s ScienceCloud Protocol Exchange. Data collection and analysis methods for the screening of covalent adducts of intact proteins are now fast enough to screen the largest covalent compound libraries in 1–2 days.
A combined use of intravoxel incoherent motion MRI parameters can differentiate early stage hepatitis-b fibrotic livers from healthy livers
Authors: Wáng Yì Xiáng J. , Deng Min , Li Yáo T. , Huang Hua , Leung Jason Chi Shun , Chen Weitian , Lu Pu-Xuan 
Published: May 2017

AbstractThis study investigated a combined use of IVIM parameters Dslow (D), PF (f) and Dfast (D*) for liver fibrosis evaluation. 16 healthy volunteers (F0) and 33 hepatitis-b patients (stage F1= 15, stage F2-4 = 18) were included. With a 1.5-T MR scanner and respiration-gating, IVIM diffusion weighted imaging was acquired using a single-shot echo-planar imaging sequence with tenb-values of 10, 20, 40, 60, 80, 100, 150, 200, 400, and 800 s/mm2. Signal measurement was performed on right liver parenchyma. With a 3-dimensional tool, Dslow, PF, and Dfast values were placed along the x-axis, y-axis, and z-axis, and a plane was defined to separate healthy volunteers from patients. 3-dimensional tool demonstrated healthy volunteers and all patients with liver fibrosis could be separated. Classification and Regression Tree showed a combination of PF (PF < 12.55%), Dslow (Dslow < 1.152 ×10−3mm2/s) and Dfast (Dfast <13.36 ×10−3mm2/s) could differentiate healthy subjects and all fibrotic livers (F1-F4) with an area under the curve of logistic regression (AUC) of 0.986. The AUC for differentiation of healthy livers vs. F2-4 livers was 1. PF offered the best diagnostic value, followed by Dslow; however, all three parameters of PF, Dslow, and Dfast contributed to liver fibrosis detection.
Novel chemolithotrophic and anoxygenic phototrophic genomes extracted from ice-covered boreal lakes
Authors: Sinclair Lucas , Peura Sari , Hernández Pilar , Schattenhofer Martha , Eiler Alexander 
Published: May 2017

AbstractAlthough an important fraction of the world’s lakes remains ice-covered during a large proportion of the year, little is known about the microorganisms that govern the biogeochemical processes occurring under-ice along the stratigraphic redox gradients. Reconstructed genomes provide evidence for anoxygenic photosynthesis involving fixation of carbon using reduced sulphur and iron as an electron donor in the anoxic zone of the sampled lake systems. In addition to anoxygenic photosynthesis, our molecular data reveals novel chemolithoautotrophic organisms and supports the existence of methanotrophs in bottom anoxic waters. Reconstructed genomes matched methanotrophs related toMethylobactertundripaludum, phototrophicChloroflexiandChlorobia, as well as lithoautotrophic genomes affiliated to theBetaproteobacteriaclass andPlanctomycetesphylum. Based on our in-depth characterization, complex metabolic interactomes emerge unique to each lake’s redox tower and with sulfur, iron and carbon cycling tightly intertwined through chemolithotrophy and anoxygenic photosynthesis.
Resilience in children and young people with intellectual disabilities: a review of literature
Authors: Raghavan Raghu , Griffin Edward 
Published: May 2017

PurposeBuilding the resilience of children with intellectual disabilities (ChID) can help reduce the personal, social and economic costs associated with mental ill health among such children. The purpose of this paper is to review the research evidence on resilience in ChID and to suggest areas for further research.Design/methodology/approachJournal articles published in the last 20 years were searched in on-line databases to find potential papers for this review. The inclusion criteria were to search for published journal articles covering the theme of resilience in ChID and their families. All identified titles and abstracts were screened which resulted in 50 articles. These were scrutinised more thoroughly and 34 remaining articles were selected for review.FindingsResilience is a dynamic process involving interactions between various risk and protective processes both internal and external to the individual that act to mediate the influences of adverse life events. Five key themes were identified within the literature which helped to form a picture of the current understanding of resilience among ChID and their careers. These were increased risk factors associated with ID, the role of personal attributes on resilience, family and resilience, schooling and resilience, and cultural factors which enhance resilience.Originality/valueDespite the consistency with which poor outcomes for ChID have been reported there is little investigation of the specific causes, contributory factors and processes that might improve them. This paper contributes to greater understanding of resilience factors for children and young people with ID and provides areas for further research.
Adherence of clinicians to guidelines for the prescription of antipsychotic drugs to people with intellectual disabilities
Authors: Ramerman Lotte , de Kuijper Gerda , Hoekstra Pieter J. 
Published: May 2017

PurposeAntipsychotic drugs are frequently prescribed to people with intellectual disabilities (ID) to ameliorate psychotic symptoms and behavioural symptoms with and without mental condition. Guidelines recommend systematic evaluation of treatment effects and adverse effects, and limiting the treatment duration. Studies have shown that adherence to prescription guidelines is beneficial for clients’ outcomes. Therefore, the purpose of this paper is to investigate the adherence to antipsychotic drug prescription guidelines in two treatment settings.Design/methodology/approachA checklist, based on existing antipsychotic drug prescription guidelines, was used to evaluate the adherence of prescribers to guidelines in two settings in the Netherlands, i.e., in specialized intellectual disability (ID) care organizations and mental health care organizations. Data from medical records of clients who used antipsychotic drugs (n=299) were compared to the items of the checklist.FindingsTreatment effects were measured with validated scales in both settings in only 2.7 per cent of cases. Prescriptions were for problem behaviour in the absence of a psychotic disorder or psychotic symptoms in 90 per cent (specialized ID care) and in 79 per cent (mental health care) of cases. In specialized ID care pipamperone (31.9 per cent) and in mental health care risperidone (48.5 per cent) was most often prescribed. Adverse effects were monitored more frequently in specialized ID care.Originality/valueThe adherence to guidelines for prescribing antipsychotic drug to people with ID is insufficient in the Netherlands, because of shortcomings in the evaluation of treatment and adverse effects.
The business model and intellectual capital in the value creation of firms
Authors: Ujwary-Gil Anna 
Published: May 2017

Purpose
The purpose of this paper is to analyze business model (BM) and intellectual capital (IC) of a firm with a focus on their common elements. The common bases in the field of strategic management for these two concepts are, among others, resource-based view, knowledge-based view, intellectual capital-based view, dynamic capabilities, and configurational approach. It indicates areas in which these two concepts can benefit from each other, e.g. in classification of components, their configuration, or dynamic approach. This general review examines the following research questions: What are the common concepts for the BM and IC? What are their common components? What does the dynamic approach to IC and BM mean?

Design/methodology/approach
The Web of Science™ Core Collection database was selected for the period 1975-2014 and the Journal of Intellectual Capital (JIC) indexed in Scopus® (Elsevier) was incorporated into the analysis for the period it had been indexed by Scopus (1990-2015). These databases were selected because they offer a reliable overview of historical data regarding journals, articles, and citation impact. The key filter criteria were the presence of the phrases “business model” or “intellectual capital” in the article title, abstract, and key words in order to narrow down the selection to the most appropriate results for the research area.

Findings
This paper investigates two concepts from the point of view of their underpinnings in management, definitions, and components, as well as value creation. Analysis of the foundations in management allows the author to present a cohesive model, which depicts a comprehensive approach to analysis of these two concepts. Many common elements have been identified and investigated.

Originality/value
First, it provides an indication of the common underpinnings of the analyzed concepts within the framework of strategic management and proposals for their development toward resource, knowledge, and IC accumulation, combination and heterogeneity-based views. Second, it presents an analysis of the BM and IC components, showing common elements between them. Third, it provides a description and analysis of dynamic view of BM and IC components in a value creation context.
Directing our own careers, but getting help from empowering leaders
Authors: Kim Minseo , Beehr Terry A. 
Published: May 2017

PurposeThe purpose of this paper is to examine the potential effects of empowering leadership on followers’ subjective career success through psychological empowerment, protean career orientation, and career commitment.Design/methodology/approachFull-time employees working in the USA were recruited through Amazon’s Mechanical Turk. Participants answered surveys at three separate points over a six-week period (n=261). Structural equation modeling and bootstrapping were used to verify the indirect effect of empowering leadership on career satisfaction controlling for common method variance and growth need strength.FindingsEmpowering leadership was positively related to followers’ subsequent psychological empowerment, which in turn predicted protean career attitudes and career commitment, but only career commitment had a significant relationship with career satisfaction.Research limitations/implicationsEmpowering leadership behaviors focus on potentially career-enhancing factors, including providing followers with the confidence, inspiration, and authority to assume control of their work lives. Empowering leaders benefit their followers’ careers, and psychological empowerment and career commitment may be important mechanisms in the empowering leadership-career success relationship when their effects are considered simultaneously. Employees’ development of a protean career orientation has less direct effect on subjective career success than simple commitment to a career.Originality/valueEmpowering leadership has been overlooked in career literature. The findings advance the understanding of how empowering leader behaviors could help employees’ subjective career success in a serial mediation model. Additionally, the study empirically demonstrates that psychologically empowered employees are more likely to engage in protean career actions and navigate their own career goals.