bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, Attitude, and Practice of Parents Regarding Antibiotic Usage in Treating Children’s Upper Respiratory Tract Infection at Primary Health Clinic in Kuala Lumpur, Malaysia
Authors: Teck Koh Chee , Ghazi Hasanain Faisal , Bin Ahmad Mohd Ikhwan , Binti Abdul Samad Nuraqilah , Ee Yu Karen Lai , Binti Ismail Nurul Farhana , Bin Esa Muhammad Amirul Aizat 
Published: May 2016

Objectives: To assess the knowledge, attitude, and practice of parents regarding antibiotic usage for treating upper respiratory tract infection (URTI) among children. Methods: A cross-sectional study was conducted among 320 randomly selected parents attending a primary health clinic using self-administered questionnaires. Results: About two-thirds (69.1%) of the parents had poor knowledge level. Only 25.2% and 21.6% of the parents could correctly identify amoxicillin and penicillin as the treatment of children’s URTI. However, about two-thirds (67.5%) of the parents were aware of the antibiotic resistance caused by overuse of antibiotics. A significant association was noted between the father’s and mother’s educational level and family income with the knowledge level. Only mother’s educational level depicted a significant association with the attitude. Conclusion: The knowledge of parents regarding antibiotic usage for URTI was poor. More numbers of health promotions and educational campaigns are required to help parents understand about antibiotic usage.
Demonstration of the test-retest reliability and sensitivity of the Lower Limb Functional Index-10 as a measure of functional recovery post burn injury: a cross-sectional repeated measures study design
Authors: Ryland Margaret E. , Grisbrook Tiffany L. , Wood Fiona M. , Phillips Michael , Edgar Dale W. 
Published: May 2016

Abstract

Background
Lower limb burns can significantly delay recovery of function. Measuring lower limb functional outcomes is challenging in the unique burn patient population and necessitates the use of reliable and valid tools. The aims of this study were to examine the test-retest reliability, sensitivity, and internal consistency of Sections 1 and 3 of the Lower Limb Functional Index-10 (LLFI-10) questionnaire for measuring functional ability in patients with lower limb burns over time.

Methods
Twenty-nine adult patients who had sustained a lower limb burn injury in the previous 12 months completed the test-retest procedure of the study. In addition, the minimal detectable change (MDC) was calculated for Section 1 and 3 of the LLFI-10. Section 1 is focused on the activity limitations experienced by patients with a lower limb disorder whereas Section 3 involves patients indicating their current percentage of pre-injury duties.

Results
Section 1 of the LLFI-10 demonstrated excellent test-retest reliability (intra-class correlation coefficient (ICC) 0.98, 95 % CI 0.96–0.99) whilst Section 3 demonstrated high test-retest reliability (ICC 0.88, 95 % CI 0.79–0.94). MDC scores for Sections 1 and 3 were 1.27 points and 30.22 %, respectively. Internal consistency was demonstrated with a significant negative association (rs = −0.83) between Sections 1 and 3 of the LLFI-10 (p &lt; 0.001).

Conclusions
This study demonstrates that Section 1 and 3 of the LLFI-10 are reliable for measuring functional ability in patients who have sustained lower limb burns in the previous 12 months, and furthermore, Section 1 is sensitive to changes in patient function over time.
Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+ T cells through p65 and H2B phosphorylation
Authors: Li Jasmine , Hardy Kristine , Phetsouphanh Chan , Tu Wen Juan , Sutcliffe Elissa L. , McCuaig Robert , Sutton Christopher R. , Zafar Anjum , Munier C. Mee Ling , Zaunders John J. , Xu Yin , Theodoratos Angelo , Tan Abel , Lim Pek Siew , Knaute Tobias , Masch Antonia , Zerweck Johannes , Brezar Vedran , Milburn Peter J. , Dunn Jenny , Casarotto Marco G. , Turner Stephen J. , Seddiki Nabila , Kelleher Anthony D. , Rao Sudha 
Published: May 2016

ABSTRACT
Memory T cells are characterized by their rapid transcriptional programs upon re-stimulation. This transcriptional memory response is facilitated by permissive chromatin, but exactly how the permissive epigenetic landscape in memory T cells integrates incoming stimulatory signals remains poorly understood. By genome-wide ChIP-sequencing ex vivo human CD4+ T cells, here, we show that the signaling enzyme, protein kinase C theta (PKC-θ) directly relays stimulatory signals to chromatin by binding to transcriptional-memory-responsive genes to induce transcriptional activation. Flanked by permissive histone modifications, these PKC-enriched regions are significantly enriched with NF-κB motifs in ex vivo bulk and vaccinia-responsive human memory CD4+ T cells. Within the nucleus, PKC-θ catalytic activity maintains the Ser536 phosphorylation on the p65 subunit of NF-κB (also known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition through Ser32 phosphorylation. Furthermore, using a cytoplasm-restricted PKC-θ mutant, we highlight that chromatin-anchored PKC-θ integrates activating signals at the chromatin template to elicit transcriptional memory responses in human memory T cells.
Pain and pleasures of the look: The female gaze in Malaysian horror film
Authors: Izharuddin Alicia 
Published: May 2016

Abstract
Female ghosts and other supernatural entities, including the pontianak, in Malaysian horror cinema are excessive psychosocial articulations of traditional Malay femininity gone awry. In Malay ghost stories, the pontianak is a vengeful spirit. She is the ghostly reincarnation of a pregnant woman who dies before or during the birth of her child and who then seeks vengeance on the living for causing the gruesome death that kills her and her unborn child. Since biological reproduction is the primary determinant of a woman’s social value in traditional Malay societies, the double death is devastatingly cruel. The pontianak thus embodies the horror of abject femininity associated with thwarted womanhood. Another recurring theme in Malaysian horror cinema relates to women possessed by evil spirits. Typically portrayed as lacking in emotional restraint, and therefore given to hysterical behaviour, such women are thought to be particularly vulnerable. Malaysian horror cinema has been adept at depicting psychosocial horrors of feminine excesses as such that transgress otherwise restrictive social and customary expectations for Malay femininity. This article examines the horror of abject femininity in two contemporary Malaysian films by female film-makers: Shuhaimi Baba’s Pontianak Harum Sundal Malam/Pontianak of the Tuber Rose (2004) and Zarina Abdullah’s Chermin/Mirror (2007). Both films collectively provide a spine-chilling commentary on female–female relations and motherhood that puts to play the female gaze and the monstrous feminine. This article argues that the themes of failed motherhood, death and the abject are salvaged by strong mother–daughter relations and the female gaze, making the two films a women-oriented rejoinder to spirit possession and the misogynistic tale of the pontianak.
‘Friending’ Jet Li on Facebook: The Chinese celebrity persona in online social networks
Authors: Lau Dorothy 
Published: May 2016

Abstract
In recent years, well-known martial arts movie actor Jet Li has attained phenomenal success through star-powered philanthropy, even establishing his own worldwide humanitarian charity, One Foundation. With the advent of participatory Web-based culture, cyberspace becomes an emergent locus of constructing and reinventing Li’s star image. This article investigates Li’s celebrity-philanthropist image in cyberspace and its signification. The analysis focuses on Facebook Pages, an organized virtual space displaying content including user interactions and microblogging known as a timeline. This article argues that Facebook presents a new and promising venue for users to negotiate Li’s ‘polysemic’ personae as martial arts master and philanthropist juxtapose, parallel and contradict each other in a decidedly nationalist vs cosmopolitan manner. Li’s national-yet-cosmopolitan personality not only yields an image of a viable global player in the entertainment arena but also serves as a text of linked significations opened up for users’ relentless (re)making, revisiting and interrogating, complicating the meaning of Chinese celebrities in the milieu of globalcyber culture.
Review
Authors: Henderson Brian 
Published: May 2016

Abstract
INHABITING MULTIPLE WORLDS: IMMERSIVE LITERACY PRACTICES AND GAMING CULTURE: COMPUTER GAMES AND TECHNICAL COMMUNICATION: CRITICAL METHODS & APPLICATIONS AT THE INTERSECTION, JENNIFER DEWINTER AND RYAN M. MOELLER (EDS) (2014) 1st ed., Burlington, VT: Ashgate Publishing Company, 314 pp., ISBN: 9781472426406, h/bk, $119.95 (USD)
Causes and Effects of Adverse Events During Water Supply and Sewerage System Constructions
Authors: Rybka I. , Bondar-Nowakowska E. , Połoński M. 
Published: May 2016

Abstract This paper identifies the adverse events occurring during the execution of water supply and sewerage systems construction. The basis for this paper is research conducted in 2010-2014 on the construction sites of water supply and sewerage systems located in the provinces of Lower Silesia and Opole. The research consisted of direct observations of construction sites and review of construction documentation. It showed that work stoppages on the examined construction sites were frequent. They were caused by violations of work discipline by the production employees, adverse weather conditions, and defects in the project documentation. The study demonstrated that in almost every case, these bad an adverse effect on the completion date and budget of the investment. The analyses show that in such important and expensive investments as water supply and sewerage systems, organizational structures in which a special role is assigned to middle-rank personnel should be adopted.
Does using the ecosystem services concept provoke the risk of assigning virtual prices instead of real values to nature? Some reflections on the benefit of ecosystem services for planning and policy consulting
Authors: Fürst Christine 
Published: May 2016

Abstract
This forum article intends to discuss the question if using the ecosystem services concept in planning, management and decision-making can impair nature conservation objectives by hiding the intrinsic values of nature through overemphasizing monetary aspects in environmental assessments. The conclusion is drawn that using ecosystem services in a holistic social-ecological system understanding would help to overcome justified criticisms of a too narrow perspective on the real values of nature.
The article is referring to and reflecting some thoughts and criticism of “Concerns about the use of ES as a tool for nature conservation: From misleading concepts to providing a price for nature, but not a value” by Morelli and Moller (2015).
The Coming of Age of the Lutheran Congregation in Early Modern Amsterdam
Authors: Hiebsch Sabine 
Published: May 2016

Abstract
Contrary to most of the German Lands of the Empire, Lutherans in the Low Countries were a religious minority. In order to establish a congregation in the nascent Dutch republic the Amsterdam Lutherans had to manoeuver between a non-Lutheran authority, the public Reformed Church with the most rights and the highest visibility and other religious minorities. This article describes the influencing factors that helped the Lutherans in this ongoing dynamic and vulnerable process of negotiation. It shows how experiences made by the first generations of Dutch Lutherans in Antwerp were important for the choice to start as a house church. It further explores the international connections of the Amsterdam Lutherans, especially with Scandinavia, that eventually made it possible for them to own two big, publicly visible churches, while still being a religious minority.
The Council of Trent and the Residence of Bishops in the Diocese of Cape Verde (1553–1705)
Authors: Pereira Jairzinho Lopes 
Published: May 2016

Abstract
The Council of Trent (1545–1563) regarded the reform of the episcopate as the cornerstone of the Catholic Reformation. Hence the Conciliar Fathers put emphasis on the much neglected duty of residence of bishops. To ensure compliance, the Roman Catholic Church relied heavily on Christian monarchs, patrons of the Churches in the territories under their jurisdiction. The present study analyses to what extent the Tridentine decree on the residence of bishops was enforced in the diocese of Cape Verde (under Portuguese control) between 1553 and 1705. The hypothesis of this study can be stated simply: despite the efforts to enforce the residence of bishops in Cape Verde, the socio-economic limitations of the diocese as well as political and administrative constraints in Portugal significantly hampered the authorities in their effort to enforce long-term residence in that overseas diocese.
Crystal structure of poly[bis(μ2-4-(3-(pyridin-3-yl)-1H-1,2,4-triazol-5-yl)benzoato-κ3
N:O,O′)-lead(II)], C28H18O4N8Pb
Authors: Chen Shi-Jun , Li Lei , Liu Bao-Wei , Ji Ke-Zhi , Xia Xiao-Dong , Mu Kai , Liu Wei 
Published: May 2016

Abstract
C28H18O4N8Pb, triclinic, P1̅ (no. 2), a = 9.4277(16) Å, b = 10.9506(18) Å, c = 12.689(2) Å, α = 86.356(2)°, β = 76.565(2)°, γ = 89.669(2)°, V = 1271.5(4) Å3, Z = 2, R
gt
(F) = 0.0295, wR
ref
(F
2
) = 0.0808, T = 293(2) K.
Flying Eyes and Hidden Controllers: A Qualitative Study of People’s Privacy Perceptions of Civilian Drones in The US
Authors: Wang Yang , Xia Huichuan , Yao Yaxing , Huang Yun 
Published: May 2016

Abstract
Drones are unmanned aircraft controlled remotely or operated autonomously. While the extant literature suggests that drones can in principle invade people’s privacy, little is known about how people actually think about drones. Drawing from a series of in-depth interviews conducted in the United States, we provide a novel and rich account of people’s privacy perceptions of drones for civilian uses both in general and under specific usage scenarios. Our informants raised both physical and information privacy issues against government, organization and individual use of drones. Informants’ reasoning about the acceptance of drone use was in part based on whether the drone is operating in a public or private space. However, our informants differed significantly in their definitions of public and private spaces. While our informants’ privacy concerns such as surveillance, data collection and sharing have been raised for other tracking technologies such as camera phones and closed-circuit television (CCTV), our interviews highlight two heightened issues of drones: (1) powerful yet inconspicuous data collection, (2) hidden and inaccessible drone controllers. These two aspects of drones render some of people’s existing privacy practices futile (e.g., notice recording and ask controllers to stop or delete the recording). Some informants demanded notifications of drones near them and expected drone controllers asking for their explicit permissions before recording. We discuss implications for future privacy-enhancing drone designs.
The PROFILE Feasibility Study: Targeted Screening of Men With a Family History of Prostate Cancer
Authors: Castro Elena , Mikropoulos Christos , Bancroft Elizabeth K. , Dadaev Tokhir , Goh Chee , Taylor Natalie , Saunders Edward , Borley Nigel , Keating Diana , Page Elizabeth C. , Saya Sibel , Hazell Stephen , Livni Naomi , deSouza Nandita , Neal David , Hamdy Freddie C. , Kumar Pardeep , Antoniou Antonis C. , Kote-Jarai Zsofia ,   The PROFILE Study Steering Committee, Eeles Rosalind A. 
Published: May 2016

Abstract

Background.
A better assessment of individualized prostate cancer (PrCa) risk is needed to improve screening. The use of the prostate-specific antigen (PSA) level for screening in the general population has limitations and is not currently advocated. Approximately 100 common single nucleotide polymorphisms (SNPs) have been identified that are associated with the risk of developing PrCa. The PROFILE pilot study explored the feasibility of using SNP profiling in men with a family history (FH) of PrCa to investigate the probability of detecting PrCa at prostate biopsy (PB). The primary aim of this pilot study was to determine the safety and feasibility of PrCa screening using transrectal ultrasound-guided PB with or without diffusion-weighted magnetic resonance imaging (DW-MRI) in men with a FH. A secondary aim was to evaluate the potential use of SNP profiling as a screening tool in this population.

Patients and Methods.
A total of 100 men aged 40–69 years with a FH of PrCa underwent PB, regardless of their baseline PSA level. Polygenic risk scores (PRSs) were calculated for each participant using 71 common PrCa susceptibility alleles. We treated the disease outcome at PB as the outcome variable and evaluated its associations with the PRS, PSA level, and DW-MRI findings using univariate logistic regression.

Results.
Of the 100 men, 25 were diagnosed with PrCa, of whom 12 (48%) had clinically significant disease. Four adverse events occurred and no deaths. The PSA level and age at study entry were associated with PrCa at PB (p = .00037 and p = .00004, respectively).

Conclusion.
The results of the present pilot study have demonstrated that PB is a feasible and safe method of PrCa screening in men with a FH, with a high proportion of PrCa identified requiring radical treatment. It is feasible to collect data on PrCa-risk SNPs to evaluate their combined effect as a potential screening tool. A larger prospective study powered to detect statistical associations is in progress.
A Comprehensive Look at Polypharmacy and Medication Screening Tools for the Older Cancer Patient
Authors: Whitman Andrew M. , DeGregory Kathlene A. , Morris Amy L. , Ramsdale Erika E. 
Published: May 2016

Abstract
Inappropriate medication use and polypharmacy are extremely common among older adults. Numerous studies have discussed the importance of a comprehensive medication assessment in the general geriatric population. However, only a handful of studies have evaluated inappropriate medication use in the geriatric oncology patient. Almost a dozen medication screening tools exist for the older adult. Each available tool has the potential to improve aspects of the care of older cancer patients, but no single tool has been developed for this population. We extensively reviewed the literature (MEDLINE, PubMed) to evaluate and summarize the most relevant medication screening tools for older patients with cancer. Findings of this review support the use of several screening tools concurrently for the elderly patient with cancer. A deprescribing tool should be developed and included in a comprehensive geriatric oncology assessment. Finally, prospective studies are needed to evaluate such a tool to determine its feasibility and impact in older patients with cancer.
Characterizing driver–response relationships in marine pelagic ecosystems for improved ocean management
Authors: Hunsicker Mary E. , Kappel Carrie V. , Selkoe Kimberly A. , Halpern Benjamin S. , Scarborough Courtney , Mease Lindley , Amrhein Alisan 
Published: May 2016

AbstractScientists and resource managers often use methods and tools that assume ecosystem components respond linearly to environmental drivers and human stressors. However, a growing body of literature demonstrates that many relationships are non‐linear, where small changes in a driver prompt a disproportionately large ecological response. We aim to provide a comprehensive assessment of the relationships between drivers and ecosystem components to identify where and when non‐linearities are likely to occur. We focused our analyses on one of the best‐studied marine systems, pelagic ecosystems, which allowed us to apply robust statistical techniques on a large pool of previously published studies. In this synthesis, we (1) conduct a wide literature review on single driver–response relationships in pelagic systems, (2) use statistical models to identify the degree of non‐linearity in these relationships, and (3) assess whether general patterns exist in the strengths and shapes of non‐linear relationships across drivers. Overall we found that non‐linearities are common in pelagic ecosystems, comprising at least 52% of all driver–response relationships. This is likely an underestimate, as papers with higher quality data and analytical approaches reported non‐linear relationships at a higher frequency (on average 11% more). Consequently, in the absence of evidence for a linear relationship, it is safer to assume a relationship is non‐linear. Strong non‐linearities can lead to greater ecological and socioeconomic consequences if they are unknown (and/or unanticipated), but if known they may provide clear thresholds to inform management targets. In pelagic systems, strongly non‐linear relationships are often driven by climate and trophodynamic variables but are also associated with local stressors, such as overfishing and pollution, that can be more easily controlled by managers. Even when marine resource managers cannot influence ecosystem change, they can use information about threshold responses to guide how other stressors are managed and to adapt to new ocean conditions. As methods to detect and reduce uncertainty around threshold values improve, managers will be able to better understand and account for ubiquitous non‐linear relationships.