bluuebunny/crossref_metadata_2025_split huggingface dataset:
RSV Neutralizing Antibodies Following Nirsevimab and Palivizumab Dosing
Authors: Wilkins Deidre , Wählby Hamrén Ulrika , Chang Yue , Clegg Lindsay E. , Domachowske Joseph , Englund Janet A. , Muller William J. , Leach Amanda , Kelly Elizabeth J. , Villafana Tonya 
Published: October 2024

BACKGROUND
Data describing respiratory syncytial virus (RSV) neutralizing antibody (nAb) levels for nirsevimab, a recently approved, extended half-life, anti-RSV fusion protein (F protein) monoclonal antibody, relative to the previous standard of care, palivizumab, have not been reported.

METHODS
MEDLEY was a randomized, palivizumab-controlled, phase 2/3 study of nirsevimab during 2 RSV seasons (season 1 and 2) in infants born preterm (≤35 weeks’ gestational age; dosed season 1 only) or with congenital heart disease or chronic lung disease of prematurity (dosed seasons 1 and 2). Participants were randomly assigned to receive a single dose of nirsevimab followed by 4 monthly placebo doses, or 5 once-monthly doses of palivizumab. Anti-RSV F protein serology (ie, levels of prefusion [pre-F]/postfusion [post-F] conformation antibodies), nirsevimab and palivizumab concentrations, and RSV nAbs were measured in participant serum collected at baseline (pre-dose) and days 31, 151, and 361.

RESULTS
Serologic data were similar in seasons 1 and 2. Nirsevimab predominately conferred pre-F antibodies, whereas palivizumab conferred pre-F and post-F antibodies. Nirsevimab and palivizumab serum concentrations highly correlated with nAb levels in both seasons. In season 1, nAb levels in nirsevimab recipients were highest in day 31 samples and gradually declined but remained 17-fold above baseline at day 361. nAb levels in palivizumab recipients increased incrementally with monthly doses to day 151. nAb levels followed similar patterns in season 2. nAb levels were ∼10-fold higher with nirsevimab compared with palivizumab across both seasons.

CONCLUSIONS
Nirsevimab prophylaxis confers ∼10-fold higher and more sustained RSV nAb levels relative to palivizumab.
A munkafüggőség és a technológiai függőségek kapcsolatának vizsgálata egy hazai reprezentatív, longitudinális kutatás tükrében
Authors: Kun Bernadette , Paksi Borbála , Eisinger Andrea , Demetrovics Zsolt 
Published: October 2024

Háttér és célkitűzések: A munkafüggőség egy olyan viselkedési addikció, amely számos negatív következménnyel jár, s mindez érintheti a testi, pszichés és társas kapcsolati jóllétet. A munkafüggők körében gyakoribb a szerhasználat, emellett kedvezőtlenebb egészség-magatartással és egészségtelenebb életmóddal jellemezhetők. A folyamatos túlterheltség, a magasabb szorongás és negatív affektivitás, és a szerfogyasztással való kapcsolat felveti a munkafüggőség más viselkedési addikciókkal, mint a problémás internet-, mobiltelefon- és közösségimédia-használattal való kapcsolatát. Kutatásunk célja volt ezen függőségek együttjárásának longitudinális vizsgálata. Feltételeztük, hogy a maladaptív kogníciók, mint a rágódás és az aggodalmaskodás mediátor szerepet töltenek be a zavarok kapcsolatában. Módszer: Egy három adatfelvételi hullámból (T1: 2019. március–július, T2: 2020. június–szeptember, T3: 2021. június–november) álló longitudinális vizsgálatot végeztünk budapesti, 18–34 év közötti személyek reprezentatív mintáján (N = 2563). A Bergen Munkafüggőség Skálát, a Problémás Mobiltelefonhasználat Kérdőívet, a Problémás Internethasználat Kérdőívet, a Bergen Közösségi Média Függőség Skálát, a Ruminatív Válaszstílus Kérdőívet és a Penn-State Aggodalmaskodás Kérdőívet alkalmaztuk. Eredmények: A T1 munkafüggőség szignifikáns gyenge negatív kapcsolatban áll a T2 és T3 túlzott mobiltelefon-használattal, azonban pozitív és közepes erősségű kapcsolatot mutat a T2 és T3 problémás internet- és közösségimédia-használattal. Útmodellelemzéseink kimutatták, hogy a T2 rágódás és aggodalmaskodás mediál a T1 munkafüggőség és a T3 problémás internet- és közösségimédia-használat között. Következtetések: Eredményeink hangsúlyozzák, hogy a munkafüggőség komorbiditást mutat más viselkedési függőségekkel, emellett rámutatnak a perszeveratív kogníciók szerepére is. A munkafüggőség megelőzése és kezelése szempontjából érdemes a ruminációt és a rágódást a fókuszba helyezni, és ezek csökkentése jótékony hatással lehet a munkafüggőség és az azzal együtt járó problémás technológiahasználat tüneteinek csökkentésére.
Influences of mechanical decompression using different forces on knee joint space, range of motion, and hamstring flexibility in asymptomatic subjects
Authors: Hussein Hisham Mohamed , Ibrahim Ahmed Abdelmoniem , Fadulelmulla Ibtisam Abdallah , Ansari Aisha , Ali Mohammad Shahid , Aljaluod Taif Saad , Farrag Ahmed Taha 
Published: October 2024

INTRODUCTION: Knee joint decompression is one of the promising methods for the treatment of osteoarthritis. Yet, the most appropriate decompression force is not conclusive. OBJECTIVES: To compare the effect of different distraction force magnitudes on knee joint space, active range of motion (ROM), hamstring flexibility, and self-reported discomfort in asymptomatic subjects. METHODS AND MATERIALS: Twenty-five asymptomatic participants were recruited in this study. The dominant knee was distracted for 30 minutes in a 30° flexion position using three force magnitudes (10%, 20%, and 30% body weight (BW)). The traction forces were randomized with one week in between knee distractions. Joint space, range of motion (ROM), and hamstring flexibility were assessed before, immediately after, and 30 minutes after the distraction. The self-reported discomfort was assessed immediately after the distraction only. RESULTS: Medial joint space, ROM, and discomfort showed a significant difference between different force magnitudes post-distraction. The 20% and 30% BW force magnitudes significantly, but equally, increased joint space and ROM post distraction. The discomfort level was directly related to distraction force magnitude and the least comforting was the 30% BW force. Follow-up data was not significantly different than that for post-distraction. Hamstring muscle flexibility showed a significant. Yet, small increase after the 30% BW distraction force. CONCLUSION: Continued mechanical distraction of the knee joint using force magnitudes of 20% and 30% of body weight was effective in increasing medial joint space, active knee ROM, and hamstring flexibility in asymptomatic individuals. 20% force magnitude was more comfortable than the 30% percent.
CLUSTER ANALYSIS OF OBESITY RISK LEVELS USING K-MEANS AND DBSCAN METHODS
Authors: Geovani Dite , Umari Zainal , Ramadini Suci 
Published: October 2024

Obesity is defined as excessive fat accumulation and abnormal accumulation of adipose tissue in the human body that poses health risks. The causes of obesity are multifactorial and include environmental and individual factors. Several factors that cause obesity include genetic, behavioral and environmental factors. Obesity causes various problems in various fields, including health, employment, demographics, economics and family. The problem of obesity has a significant impact on public health. Therefore, understanding and predicting the level of obesity risk is important in efforts to prevent and treat obesity risk. Data on eating habits, physical activity, and other factors associated with obesity levels in certain populations can provide an important basis for understanding obesity risk. This research clusters the risk of obesity to find hidden patterns in the data. The stages in this research consist of pre-processing, clustering, and analysis. The clustering methods used are K-means and DBSCAN. In clustering using the K-means method with a parameter value of k , results are obtained with the same pattern as clustering using the DBSCAN method with a parameter value of epsilon and a minimum sample . In clustering using the K-means method with a parameter value of k , Four clusters were formed which had different patterns. The clustering results obtained in this research can be used as an effort to prevent and treat the risk of obesity.
Genotypic Characterisation of Carbapenemases in Clinical Isolates of Acinetobacter baumannii in a Tertiary Care Teaching Hospital of Kerala
Authors: Sathyanesan Lakshmi K , Jose Rosmi , Valsan Chithra , Joy Liji Maria 
Published: October 2024

Background: The multidrug-resistant and carbapenem-resistant Acinetobacter baumannii strains are an increasing global concern. The primary cause of carbapenem resistance in A. baumannii is production of various beta-lactamases with versatile hydrolytic capacities. The present study investigates the prevalence of different carbapenemases among clinical isolates of carbapenem-resistant A. baumannii from a tertiary care teaching hospital in Kerala, India.
Methods: Non-duplicate isolates from sputum, endotracheal aspirate, pus, urine, and blood samples were included in the study. Isolate identification and antibiotic susceptibility testing of the isolates were done using vitek 2 system. A conventional polymerase chain reaction was used to detect the carbapenemase-encoding genes in the isolates.
Results: A total of the 126 isolates studied, among these 105 (83.3%) isolates were from intensive care unit patients and 21(16.6%) were from non-ICU inpatients. Most of the isolates were obtained from respiratory specimens-78(61.9%) followed by pus-33(26.2%), urine-12(9.5%) and blood- 3(2.4%). The prevalence of carbapenemase genes were as follows:blaOXA-51(n=126, 100%) blaOXA-23 (n=98, 77.7%), blaOXA-58 (n=7, 5.6%), blaNDM (n=66, 52.4%), blaIMP (n=26, 20.6%), and blaVIM (n=20, 15.9%). Among the total isolates 78 (61.9%) isolates harbored metallo-beta-lactamase genes, 47(37.3%) isolates harboured a single carbapenemase gene, while 69(54.8%) isolates harbored two or more genes.
Conclusion: This study reveals a higher prevalence of metallo-beta lactamases and the co-occurrence of multiple carbapenemase genes in Carbapenem resistant A. baumannii isolates.
Calculating the Notional Learning Hours (NLH) for Final-year Medical Students in a Clinical Surgery Clerkship Course
Authors: Shallaly Gamal E.H.A. , Saeed Nausheen , Rao Sathyarayanan 
Published: October 2024

Background: The main objective of this study is to design a method to calculate the notional learning hours (NLH) of final year medical students doing a surgical clerkship course. Secondary objectives include derivation of the Oman Qualification Framework (OQF) credits and setting a benchmark of NLH in clinical courses.Methods: This is an observational cross-sectional study which uses a quantitative way to estimate students’ NLH. A questionnaire was designed and filled by final year medical students at the end of their surgical rotation. Ethical clearance was obtained. The data were uploaded and analyzed using SPSS 25. The NLH was then calculated and mapped on the OQF template.Results:Ninety-seven students participated in the study. Students spent an average of 1.20 (0.99) hours/day to study their clinical sessions and 2.86 (1.4)/day to study for their theory sessions. The mean weekend hours of study on Friday and Saturday were 3.1 hours (2.6), and 3.2 hours (2.5), respectively. The average preparation for the end rotation and the final MD exams were 9.7 (3.3) and 10.4 (3.6) hours, respectively. We calculated the NLH of our students by adding the above data to the contact teaching hours from our course timetable. We compared our results with worldwide medical schools.Conclusion: The NLH of our surgical clerkship students was calculated and subsequently the OQF credits were derived. This suggested method is evidence-based and could be used as a guide by other clinical clerkship courses.
Creditor Driven Insolvency Resolution Law – A Review of Intent v/s Practice.
Authors: Jyoti Nair  , Bhavika Nemade  
Published: October 2024

Purpose- This paper aims to examine the effectiveness of Insolvency Law in India in addressing cases of corporate distress and enabling them to revive the business through restructuring by passing appropriate resolution as envisaged by the Law. It aims to seek evidence as to whether the ‘creditor driven insolvency resolution’ model has a propensity towards ‘resolution’ or is it driven more towards ‘liquidation’ leading to ‘value erosion.’

Design/Methodology/Approach- The paper is descriptive in nature. The paper studies the practice and impact of the Insolvency and Bankruptcy Code in India. The data reported by Insolvency and Bankruptcy Board of India have been used to examine the Insolvency law in practice.

Findings- The author argues that Indian Insolvency Law tends to lean towards ‘Liquidation’ of distressed entity rather than ‘Reorganization’ of the entity against legal wisdom behind insolvency laws to promote revival of the distressed entity. The authors also imprint that increasing instances of withdrawal of admitted cases from IBC is an indicator of distressed entities resorting to informal methods of resolving cases outside IBC.

Originality/Value- The paper puts across the dichotomy between ‘intention’ and ‘impact’ of Insolvency law in India. The study highlights deviation of insolvency resolution framework in India from the ‘Evolutionary Theory’ which states that increased dispersion of corporate ownership would lead to increased affinity towards ‘manager driven insolvency regime.’

Practical Implications-This study would be useful to insolvency resolution regulators, insolvency professionals and government to examine the insolvency law framework to improve effectiveness of Insolvency and Bankruptcy Code in practice.
Hallazgos radiográficos asociados a la alteración nerviosa posquirúrgica en la cirugía de los terceros molares inferiores
Authors: Pilco Guilcapi Alexander Wladimir , Pilco Guilcapi Samantha Angeles , Paltas Miranda Mayra Elizabeth 
Published: October 2024

Objetivo: Identificar los hallazgos radiográficos asociados a una alteración nerviosa posquirúrgica en la cirugía de los terceros molares inferiores de pacientes atendidos en el quirófano de la Facultad de Odontología durante el período 2015-2019. Materiales y métodos: Estudio transversal con una población de estudio compuesta por historias clínicas y radiografías panorámicas de pacientes que se extrajeron los terceros molares inferiores en la FOUCE (Facultad de Odontología de la Universidad Central del Ecuador) durante el período 2015-2019. La muestra se seleccionó con criterios de inclusión y exclusión. Se observó en las radiografías los signos predictores y en las notas de evolución la presencia o ausencia de una alteración nerviosa. Los datos fueron registrados en una ficha de Excel y el análisis estadístico se realizó en el programa SPSS 25.0. Se ejecutó una estadística descriptiva para frecuencias absolutas y relativas, y para la relación entre variables chi-cuadrado con un nivel de confianza del 95 %. Resultados: La frecuencia de la alteración nerviosa fue de 3,8 % (n = 16), para mayores de 25 años se presentó en un 9,7 % (n = 7), y para la clasificación Pell y Gregory tipo C y clase II en un 4,4 % (n = 6) y 2,4 % (n = 13), respectivamente. Adicionalmente, el signo raíz oscura y bífida se presentó en un 8,7 % (n = 2) de las alteraciones nerviosas. Conclusiones: Los signos radiográficos raíz oscura y bífida, pérdida de la línea blanca y desviación del canal están asociados a la alteración nerviosa posquirúrgica en la cirugía de los terceros molares inferiores.
Eficacia de la fibrina rica en plaquetas en su forma membranosa para la cobertura radicular
Authors: Sarduy Bermúdez Lázaro , Véliz Concepción Olga Lidia , Veitia Cabarrocas Felisa , Arce González Manuel Antonio , Barreto Fiu Eligio Eduardo 
Published: October 2024

Objetivo: Evaluar la eficacia de la fibrina rica en plaquetas en su forma membranosa asociada al colgajo avanzado coronalmente en pacientes atendidos por consulta en periodoncia de la Facultad de Estomatología de Villa Clara. Materiales y métodos: Se realizó un estudio longitudinal en la Facultad de Estomatología de Villa Clara, Santa Clara, Cuba, de enero de 2016 a marzo de 2017. Se trabajó con una muestra de 17 personas seleccionadas de forma no probabilística intencional. A estas se les realizó el procedimiento tradicional de colgajo avanzado coronalmente en los dientes con recesión periodontal. Debajo de dicho colgajo, se colocó una membrana de fibrina rica en plaquetas, confeccionada a partir de sangre autóloga y elaborada en el Servicio de Medicina Regenerativa de la misma institución. Se analizaron las variables edad, sexo, largo de la recesión, clasificación de Miller, cobertura radicular, ancho y ganancia de encía insertada, categorías de evaluación y eficacia de la terapéutica. Resultados: El porcentaje de cobertura radicular fue superior en la clase I y se incrementó a lo largo del tiempo en todas las clases de Miller. El ancho y la ganancia de la encía insertada aumentaron del mes hasta el año. El porcentaje de eficacia fue de 93,18 %. Conclusiones: La terapéutica de la recesión periodontal, con la forma membranosa de fibrina rica en plaquetas asociada al colgajo avanzado coronalmente, se consideró eficaz en los pacientes atendidos en la consulta de periodoncia de la Facultad de Estomatología de Villa Clara.
Pemberian ASI terhadap Komposisi Tubuh pada Bayi Prematur: A Systematic Review
Authors: Dzulkifli Achmad , Nadhiroh Siti Rahayu , Syahdana Achidah Nur 
Published: October 2024

Latar Belakang: Bayi prematur lebih rentan terhadap sindrom metabolik dan gangguan kognitif daripada bayi yang cukup bulan. Pemberian air susu ibu (ASI) telah direkomendasikan sebagai makanan alami untuk bayi prematur dan sebagai strategi ekonomi untuk mengurangi penyakit dan beban ekonomi. Mempertimbangkan pertumbuhan bayi prematur dan komposisi tubuh saat keluar dari rumah sakit merupakan hal yang sangat sensitif dan penting untuk dilakukan perawatan selanjutnya
Tujuan: Tujuan penelitian ini adalah untuk membandingkan komposisi tubuh bayi prematur dengan pemberian air susu ibu (ASI) dan susu formula.
Metode: Strategi yang digunakan dalam penelitian ini adalah survei yang teratur termasuk lima belas buku harian eksplorasi yang berlangsung dari tahun 2013-2023. Kata kunci yang digunakan yakni “breastfeeding” OR “body composition” OR “preterm infants”. Seleksi judul dan abstrak digunakan untuk memilih artikel, kemudian kriteria inklusi dan eksklusi digunakan untuk memilihnya lagi.
Diskusi: Pemberian ASI pada bayi prematur berhubungan positif dengan deposisi massa bebas lemak tubuh sehingga berkontribusi terhadap komposisi tubuh, mencegah obesitas, menghambat kerugian pada perkembangan sel saraf, dan mendukung pertumbuhan yang optimal dibandingkan pemberian susu formula. Komposisi tubuh bayi prematur berubah selama pemberian ASI pada usia yang dikoreksi cukup bulan sehingga dapat membantu mengurangi faktor risiko sindrom metabolik.
Kesimpulan: Pemberian ASI pada bayi prematur lebih lambat dalam menaikkan berat badan dibandingkan susu formula dan lebih baik dalam pemulihan komposisi tubuh melalui deposisi massa bebas lemak tubuh sehingga dapat menyebabkan peningkatan hasil metabolisme dan perkembangan saraf. Promosi ASI dan dukungan pemberian ASI menjadi prioritas dalam perawatan bayi prematur.
Fishery and stock dynamics of ribbonfish Trichiurus lepturus (Linnaeus, 1758) in the Indian Exclusive Economic Zone
Authors: Shubhadeep Ghosh  , Prathiba Rohit  , A. Margaret Muthurathinam  , K. M. Rajesh  , Mohammed Koya  , C. Anulekshmi  , Ajay D. Nakhwa  , S. Surya  , H. M. Manas  , Subal K. Roul  , P. Abdul Azeez  , R. Vinoth Kumar  
Published: October 2024

The fishery and stock dynamics of Trichiurus lepturus (Linnaeus, 1758) were studied in the Indian Exclusive Economic Zone (EEZ) for the period 2014-2019. The average annual landing was 2,09,285 t and varied from 1,77,259 to 2,39,355 t. Trawl nets were the majorgear, contributing more than 85% with an average annual catch rate of 4.56 kg h-1. The annual catch rate decreased over the years from 5.40 to 3.85 kg h-1. Landings (23,155-40,354 t) and catch rates (4.24-8.67 kg h-1) were highest during the post-monsoon months (September-December). Around 63% of the landings (1,32,072 t) were from the north-west coast, with Gujarat alone contributing three-fourth (98,296 t) of it, followed by the south-west coast (17%, 36,017 t), the south-east coast (12%, 25,322 t) and the north-east coast (8%, 15,875 t). The von Bertalanffy’s growth equation was Lt = 143.8 [1-e–0.48 (t + 0.03285)]. Natural mortality, Exploitation ratio and Maximum Sustainable Yield (MSY) were 0.76; 0.65 and 1,59,504 t respectively. Recruitment was substantial throughout the year with a single modal peak during June-October. With lower lengths at first capture and recruitment and with exploitation above the maximum permissible level and landings higher than MSY; the species appears to be overexploited along the Indian coasts. The present study is the first holistic report on the population parameters and stock status of T. lepturus from the Indian EEZ.

Keywords: Cutlass fishes, Management, Recruitment, Stock dynamics
Impact of mangrove defoliation by Hyblaea puera on diversity of associated crustaceans in the Dharamtar Estuary, Maharashtra, India
Authors: Chennuri Sathish  , B. Sivaiah  , K. Srinivas  , Vidya Shree Bharti  , A. K. Jaiswar  , Sudheer Joseph  , Geetanjali Deshmukhe  
Published: October 2024

Mangrove defoliation, caused by teak defoliator moth (Hyblaea puera), has been reported in India and other countries. However, research on its impact on the associated fauna remains limited. We observed extensive mangrove defoliation from August to October 2019 in the Dharamtar Estuary, Maharashtra, India. Consequently, a study was conducted to assess the impact of this defoliation on the diversity of crustaceans within the mangroves and the surrounding estuarine waters. A total of 27 crustacean species were recorded in the mangrove region exhibiting reduced species richness and abundance during the mangrove defoliation period. Whereas, a total of 32 species of crustaceans were recorded from the estuarine region, where both species richness and abundance were higher during the defoliation period. These findings indicate that the crustaceans on the mangrove floor and in the estuarine waters responded differently to the changing environmental conditions caused by defoliation.

Keywords: Crustaceans, Diversity, Estuary, Mangrove defoliation, Moth infestation