bluuebunny/crossref_metadata_2025_split huggingface dataset:
Perforated Peptic Ulcer Repair: Factors Predicting Conversion in Laparoscopy and Postoperative Septic Complications
Authors: Muller Markus K. , Wrann Simon , Widmer Jeannette , Klasen Jennifer , Weber Markus , Hahnloser Dieter 
Published: April 2016

AbstractObjectiveThe surgical treatment for perforated peptic ulcers can be safely performed laparoscopically. The aim of the study was to define simple predictive factors for conversion and septic complications.MethodsThis retrospective case–control study analyzed patients treated with either laparoscopic surgery or laparotomy for perforated peptic ulcers.ResultsA total of 71 patients were analyzed. Laparoscopically operated patients had a shorter hospital stay (13.7 vs. 15.1 days). In an intention‐to‐treat analysis, patients with conversion to open surgery (analyzed as subgroup from laparoscopic approach group) showed no prolonged hospital stay (15.3 days) compared to patients with a primary open approach. Complication and mortality rates were not different between the groups. The statistical analysis identified four intraoperative risk factors for conversion: Mannheim peritonitis index (MPI) > 21 (p = 0.02), generalized peritonitis (p = 0.04), adhesions, and perforations located in a region other than the duodenal anterior wall. We found seven predictive factors for septic complications: age >70 (p = 0.02), cardiopulmonary disease (p = 0.04), ASA > 3 (p = 0.002), CRP > 100 (p = 0.005), duration of symptoms >24 h (p = 0.02), MPI > 21(p = 0.008), and generalized peritonitis (p = 0.02).ConclusionOur data suggest that a primary laparoscopic approach has no disadvantages. Factors necessitating conversions emerged during the procedure inhibiting a preoperative selection. Factors suggesting imminent septic complications can be assessed preoperatively. An assessment of the proposed parameters may help optimize the management of possible septic complications.
Comparison of Three Methods for Extraction of Volatile Lipid Oxidation Products from Food Matrices for GC–MS Analysis
Authors: Thomsen Birgitte Raagaard , Yesiltas Betül , Sørensen Ann‐Dorit Moltke , Hermund Ditte Baun , Glastrup Jens , Jacobsen Charlotte 
Published: April 2016

AbstractThe aim of this study was to compare three different collection methods; purge and trap, solid phase micro extraction and automated dynamic headspace/thermal desorption, all followed by GC–MS analysis used for the measurements of concentrations of volatile oxidation products in three different food matrices, namely oil, emulsion and milk. The linearity ranges of calibration curves obtained by the three different methods were compared for oil samples. Overall, the results showed that the three collection methods were comparable, although there were large differences in the linearity range of the calibration curves depending on the collection method. However, some challenges were observed for solid phase micro extraction and automated dynamic headspace/thermal desorption, namely, competition problems and overestimation of concentration by calibration curves, respectively. Based on the results, we suggest mainly to apply solid phase micro extraction on simple matrices and to be cautious with more complex matrices such as enriched milk and highly oxidized oils. Thereby, the study confirmed some challenges observed by other authors regarding competition problems on the fiber when using solid phase micro extraction. Furthermore, we observed that purge and trap, and automated dynamic headspace/thermal desorption were excellent for extraction of volatile compounds in all three matrices. However, automated dynamic headspace/thermal desorption calibration curves did provide an overestimation for oil samples so results must be interpreted with caution.
The ‘triradiate bump’: A novel radiographic sign that may confound assessment of acetabular retroversion
Authors: Morris William Z. , Li Ryan T. , Liu Raymond W. 
Published: April 2016

Purpose The triradiate cartilage transiently projects medially within the pelvic brim around the time of triradiate closure, mimicking the ischial spine sign. The purpose of this study was to characterize this newly identified radiographic sign using a longitudinal radiographic study. Methods We identified 72 subjects from a longitudinal radiographic study of healthy adolescents, each with at least four consecutive, annual anterior−posterior radiographs of the left hip, including physeal closure. Images were reviewed to identify the presence of the triradiate bump, the year it was most prominent, and the number of years relative to triradiate closure after which it had completely remodeled. Results The transient medial projection of the triradiate cartilage (triradiate bump) was identified in 26/40 (65 %) females and 22/32 (69 %) males ( p = 0.74). The medial projection of the triradiate cartilage was most prominent at 10.8 ± 0.8 years of age in females and 12.6 ± 0.7 years of age in males ( p < 0.001). The triradiate cartilage projected medially a mean of 4.7 ± 0.8 or 5.1 ± 1.4 mm for females and males, respectively ( p = 0.29), but remodeled completely in all cases around triradiate closure. Conclusions The transient medial projection of the triradiate cartilage within the pelvic brim, the ‘triradiate bump sign’, is a common radiographic finding in healthy adolescents around the time of closure of the triradiate cartilage that may mimic the ischial spine sign. These two signs can be distinguished as the projection of the ischial spine is located more inferiorly within the pelvic brim and the triradiate bump has a horizontal limb of radiolucency extending to its medial border.
Ideas and Approaches for Quality‐Assessment and Performance‐Improvement Projects in Ambulatory Surgery Centers
Authors: Allison Jan 
Published: April 2016

AbstractIdentifying a performance‐improvement project can be a struggle when a facility's data demonstrate desirable performance. Quality‐improvement teams may be limiting their data collection to only required or traditional outcome indicators. Facility personnel may need guidance on how to broaden the vision to monitor for additional issues that affect the quality of care. This article focuses on approaches and indicators customary to the services and operations of an ambulatory surgery center, going beyond reviewing data from routine outcome measures and explaining the effect these ideas can have on improving quality of care. These approaches and indicators can enable personnel to identify and conduct quality‐assessment and performance‐improvement projects that affect patient safety, patient satisfaction, efficiency, and cost of care.
A phenomenological model for fountain-top entrainment
Authors: Debugne Antoine L. R. , Hunt Gary R. 
Published: April 2016

In theoretical treatments of turbulent fountains, the entrainment of ambient fluid into the top of the fountain, hereinafter fountain-top entrainment $Q_{top}$ ($\text{m}^{3}~\text{s}^{-1}$), has been neglected until now. This neglect, which modifies the energetic balance in a fountain, compromises the predictive ability of existing models. Our aim is to quantify $Q_{top}$ by shedding light on the physical processes that are responsible for fountain-top entrainment. First, estimates for $Q_{top}$ are obtained by applying, in turn, an entrainment closure in the vein of Morton et al. (Proc. R. Soc. Lond., vol. 234, 1956, pp. 1–23) and then of Shrinivas & Hunt (J. Fluid Mech., vol. 757, 2014, pp. 573–598) to the time-averaged fountain top. Unravelling the assumptions that underlie these approaches, we argue that neither capture the dynamical behaviour of the flow observed at the fountain top; the top being characterised by quasi-periodic fluctuations, during which large-scale eddies reverse and engulf parcels of ambient fluid into the fountain. Therefore, shifting our mindset to a periodical framework, we develop a new phenomenological model in which we emphasise the role of the fluctuations in entraining external fluid. Our model suggests that $Q_{top}$ is similar in magnitude to the volume flux supplied to the fountain top by the upflow ($Q_{u}$), i.e. $Q_{top}\sim Q_{u}$, in agreement with experimental evidence. We conclude by providing guidance on how to implement fountain-top entrainment in existing models of turbulent fountains.
Nutritional composition of school meals serving children from 7 to 36 months of age in municipal day-care centres in the metropolitan area of Curitiba, Paraná, Brazil
Authors: Retondario Anabelle , Silva Débora Letícia Frizzi , Salgado Silvana Magalhães , Alves Márcia Aurelina de Oliveira , Ferreira Sila Mary Rodrigues 
Published: April 2016

AbstractThe Brazilian National School Feeding Program (PNAE) seeks to meet student’s nutritional needs during the period they remain in school. This study aimed to determine the nutritional composition of meals provided in municipal day-care centres serving children of 7–11 months (group A) and 12–36 months (group B) of age and to compare observed values with the PNAE’s and dietary reference intakes’ (DRI) recommendations. This cross-sectional study was conducted in 4 day-care centres in the metropolitan area of Curitiba, Paraná, Brazil, between June and November 2013. Food samples of six daily meals were collected during 20 non-consecutive days, totalling 120 samples. For each meal, average served and consumed portions were submitted for laboratory analysis of moisture, ash, proteins, lipids, carbohydrates, dietary fibre, Na, Ca and Fe and compared with the PNAE’s and DRI’s values. No statistically significant difference was found between age groups (P=0·793) regarding portion sizes and nutritional composition. The same menu was offered to both groups in 95 % of the meals (n 114), although the groups’ nutritional needs were different. For group A, served meals met PNAE’s recommendations for energy, carbohydrates, proteins, Na and Ca content, and consumed portions provided 70 % of the nutritional needs for carbohydrates, proteins and Ca. For group B, served portions complied with the PNAE’s values for proteins, Na and Ca. Proteins and Na reached 70 % of the nutritional needs when consumed food was evaluated. School feeding in day-care centres partially meet PNAE’s guidelines and children’s nutritional requirements, contradicting the primary objective established by the national programme.
Redefining Exploitation: Self-Employed Workers’ Movements in India's Garments and Trash Collection Industries
Authors: Agarwala Rina 
Published: April 2016

AbstractThis article examines how self-employed workers are organizing in the garments and waste collection industries in India. Although the question of who is profiting from self-employed workers’ labor is complex, the cases outlined in this paper highlight telling instances of how some self-employed workers are organizing as workers. They are fighting labor exploitation by redefining the concept to include additional exploitation axes (from the state and middle class) and forms (including sexual). In doing so, they are redefining potential solutions, including identities and material benefits, to fit their unique needs. By expanding the category of “workers” beyond those defined by a narrow focus on a standard employer-employee relationship, these movements are also fighting exclusion from earlier labor protections by increasing the number of entitled beneficiaries. These struggles provide an important corrective to contemporary analyses of labor politics that focus too heavily on the precarious nature of employer-employee relationships and too little on broader definitions of work, exploitation, and protection. These broader definitions better represent the world's mass of vulnerable workers and are being articulated from below.
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
Authors: Justin Neil , Zhang Ying , Tarricone Cataldo , Martin Stephen R. , Chen Shuyang , Underwood Elizabeth , De Marco Valeria , Haire Lesley F. , Walker Philip A. , Reinberg Danny , Wilson Jon R. , Gamblin Steven J. 
Published: April 2016

AbstractPolycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27me3) via its catalytic SET domain. A missense mutation in the substrate of PRC2, histone H3K27M, is associated with certain pediatric brain cancers and is linked to a global decrease of H3K27me3 in the affected cells thought to be mediated by inhibition of PRC2 activity. We present here the crystal structure of human PRC2 in complex with the inhibitory H3K27M peptide bound to the active site of the SET domain, with the methionine residue located in the pocket that normally accommodates the target lysine residue. The structure and binding studies suggest a mechanism for the oncogenic inhibition of H3K27M. The structure also reveals how binding of repressive marks, like H3K27me3, to the EED subunit of the complex leads to enhancement of the catalytic efficiency of the SET domain and thus the propagation of this repressive histone modification.
Low level off-road vehicle (ORV) traffic negatively impacts macroinvertebrate assemblages at sandy beaches in south-western Australia
Authors: Davies Rebecca , Speldewinde Peter C. , Stewart Barbara A. 
Published: April 2016

AbstractOff-road vehicle use is arguably one of the most environmentally damaging human activities undertaken on sandy beaches worldwide. Existing studies focused on areas of high traffic volumes have demonstrated significantly lower abundance, diversity and species richness of fauna in zones where traffic is concentrated. The impact of lower traffic volumes is unknown. This study aimed to investigate the impacts of relatively low-level vehicle traffic on sandy beach fauna by sampling invertebrate communities at eight beaches located in south-western Australia. We found that even low-level vehicle traffic negatively impacts the physical beach environment and consequently, the ability of many species to survive in this habitat in the face of this disturbance. Compaction, rutting and displacement of the sand matrix were observed over a large area, resulting in significant decreases in species diversity and density and measurable shifts in community structure on beaches that experienced off-road vehicle traffic. Communities at impact sites did not display seasonal recovery as traffic was not significantly different between seasons. Given a choice between either reducing traffic volumes, or excluding ORV traffic from beaches, our results suggest that the latter would be more appropriate when the retention of ecological integrity is the objective.
Two types of interneurons in the mouse lateral geniculate nucleus are characterized by different h-current density
Authors: Leist Michael , Datunashvilli Maia , Kanyshkova Tatyana , Zobeiri Mehrnoush , Aissaoui Ania , Cerina Manuela , Romanelli Maria Novella , Pape Hans-Christian , Budde Thomas 
Published: April 2016

AbstractAlthough hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels and the corresponding h-current (Ih) have been shown to fundamentally shape the activity pattern in the thalamocortical network, little is known about their function in local circuit GABAergic interneurons (IN) of the dorsal part of the lateral geniculate nucleus (dLGN). By combining electrophysiological, molecular biological, immunohistochemical and cluster analysis, we characterized the properties of Ih and the expression profile of HCN channels in IN. Passive and active electrophysiological properties of IN differed. Two subclasses of IN were resolved by unsupervised cluster analysis. Small cells were characterized by depolarized resting membrane potentials (RMP), stronger anomalous rectification, higher firing frequency of faster action potentials (APs), appearance of rebound bursting, and higher Ih current density compared to the large IN. The depolarization exerted by sustained HCN channel activity facilitated neuronal firing. In addition to cyclic nucleotides, Ih in IN was modulated by PIP2 probably based on the abundant expression of the HCN3 isoform. Furthermore, only IN with larger cell diameters expressed neuronal nitric oxide synthase (nNOS). It is discussed that Ih in IN is modulated by neurotransmitters present in the thalamus and that the specific properties of Ih in these cells closely reflect their modulatory options.
Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade
Authors: Yen Chia-Sheng , Chen Jung-Chien , Chang Yi-Fang , Hsu Ya-Fen , Chiu Pei-Ting , Shiue Ching , Chuang Yu-Fan , Ou George , Hsu Ming-Jen 
Published: April 2016

AbstractStatins are used widely to lower serum cholesterol and the incidence of cardiovascular diseases. Growing evidence shows that statins also exhibit beneficial effects against cancers. In this study, we investigated the molecular mechanisms involved in lovastatin-induced cell death in Fadu hypopharyngeal carcinoma cells. Lovastatin caused cell cycle arrest and apoptosis in FaDu cells. Lovastatin increased p21cip/Waf1 level while the survivin level was decreased in the presence of lovastatin. Survivin siRNA reduced cell viability and induced cell apoptosis in FaDu cells. Lovastatin induced phosphorylation of AMP-activated protein kinase (AMPK), p38 mitogen-activated protein kinase (MAPK) and transcription factor p63. Lovastatin also caused p63 acetylation and increased p63 binding to survivin promoter region in FaDu cells. AMPK-p38MAPK signaling blockade abrogated lovastatin-induced p63 phosphorylation. Lovastatin’s enhancing effect on p63 acetylation was reduced in HDAC3- or HDAC4- transfected cells. Moreover, transfection of cells with AMPK dominant negative mutant (AMPK-DN), HDAC3, HDAC4 or p63 siRNA significantly reduced lovastatin’s effects on p21cip/Waf1 and survivin. Furthermore, lovastatin inhibited subcutaneous FaDu xenografts growth in vivo. Taken together, lovastatin may activate AMPK-p38MAPK-p63-survivin cascade to cause FaDu cell death. This study establishes, at least in part, the signaling cascade by which lovastatin induces hypopharyngeal carcinoma cell death.
Colletotrichum species associated with jute (Corchorus capsularis L.) anthracnose in southeastern China
Authors: Niu Xiaoping , Gao Hong , Qi Jianmin , Chen Miancai , Tao Aifen , Xu Jiantang , Dai Zhigang , Su Jianguang 
Published: April 2016

AbstractAnthracnose, caused by the Colletotrichum species of fungi, is one of the most serious diseases affecting jute in China. The disease causes chlorotic regions with black brown sunken necrotic pits on the surfaces of stems. In late stages of disease, plants undergo defoliation, dieback and blight, which make anthracnose a major threat to jute fiber production and quality in China. In this study, 7 strains of Colletotrichum fungi were isolated from diseased jute stems from Zhejiang, Fujian, Guangxi, and Henan plantations in China. Multi-locus sequence (ACT, TUB2, CAL, GS, GAPDH and ITS) analysis coupled with morphological assessment revealed that C. fructicola, C. siamense and C. corchorum-capsularis sp. nov. were associated with jute anthracnose in southeastern China. C. fructicola and C. siamense were previously not associated with jute anthracnose. C. corchorum-capsularis is a new species formally described here. Pathogenicity tests confirmed that all species can infect jute, causing anthracnose, however the virulence of the 3 species differed. This report is the first associating these three species with jute disease worldwide and is the first description of the pathogens responsible for jute anthracnose in China.
Solar-light photocatalytic disinfection using crystalline/amorphous low energy bandgap reduced TiO2
Authors: Kim Youngmin , Hwang Hee Min , Wang Luyang , Kim Ikjoon , Yoon Yeoheung , Lee Hyoyoung 
Published: April 2016

AbstractA generation of reactive oxygen species (ROS) from TiO2 under solar light has been long sought since the ROS can disinfect organic pollutants. We found that newly developed crystalline/amorphous reduced TiO2 (rTiO2) that has low energy bandgap can effectively generate ROS under solar light and successfully remove a bloom of algae. The preparation of rTiO2 is a one-pot and mass productive solution-process reduction using lithium-ethylene diamine (Li-EDA) at room temperature. Interestingly only the rutile phase of TiO2 crystal was reduced, while the anatase phase even in case of both anatase/rutile phased TiO2 was not reduced. Only reduced TiO2 materials can generate ROS under solar light, which was confirmed by electron spin resonance. Among the three different types of Li-EDA treated TiO2 (anatase, rutile and both phased TiO2), the both phased rTiO2 showed the best performance to produce ROS. The generated ROS effectively removed the common green algae Chlamydomonas. This is the first report on algae degradation under solar light, proving the feasibility of commercially available products for disinfection.
Exploring the Association between Serum BDNF and Attempted Suicide
Authors: Eisen Rebecca B. , Perera Stefan , Bawor Monica , Dennis Brittany B. , El-Sheikh Wala , DeJesus Jane , Rangarajan Sumathy , Vair Judith , Sholer Heather , Hutchinson Nicole , Iordan Elizabeth , Mackie Pam , Islam Shofiqul , Dehghan Mahshid , Brasch Jennifer , Anglin Rebecca , Minuzzi Luciano , Thabane Lehana , Samaan Zainab 
Published: April 2016

AbstractSuicide is a leading cause of death and a significant public health concern. Brain-derived neurotrophic factor (BDNF), a protein important to nervous system function, has been implicated in psychiatric disorders and suicidal behaviour. We investigated the association between serum levels of BDNF and attempted suicide in a sample of 281 participants using a case-control study design. Participants were recruited from clinical and community settings between March 2011 and November 2014. Cases (individuals who had attempted suicide) (n = 84) were matched on sex and age (within five years) to both psychiatric controls (n = 104) and community controls (n = 93) with no history of suicide attempts. We collected fasting blood samples, socio-demographic information, physical measurements and detailed descriptions of suicide attempts. We used linear regression analysis to determine the association between BDNF level (dependent variable) and attempted suicide (key exposure variable), adjusting for age, sex, body mass index, current smoking status and antidepressant use. 250 participants were included in this analysis. In the linear regression model, attempted suicide was not significantly associated with BDNF level (β = 0.28, SE = 1.20, P = 0.82). Our findings suggest that no significant association exists between attempted suicide and BDNF level. However, the findings need to be replicated in a larger cohort study.