bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe
Authors: Lu Mengfei , Lewis Cathryn M. , Traylor Matthew 
Published: January 2017

AbstractBackgroundRapid advances in scientific research have led to an increase in public awareness of genetic testing and pharmacogenetics. Direct-to-consumer (DTC) genetic testing companies, such as 23andMe, allow consumers to access their genetic information directly through an online service without the involvement of healthcare professionals. Here, we evaluate the clinical relevance of such pharmacogenetic tests reported by 23andMe.MethodsThe research papers listed under each 23andMe report were evaluated, extracting information on effect size, sample size and ethnicity. A wider literature search was performed to provide a fuller assessment of the pharmacogenetic test and variants were matched to FDA recommendations. Additional evidence from CPIC guidelines, PharmGKB, and Dutch Pharmacogenetics Working Group was reviewed to determine current clinical practice. The value of the tests across ethnic groups was determined, including information on linkage disequilibrium between the tested SNP and causal pharmacogenetic variant, where relevant.Results23andMe offers 12 pharmacogenetic tests, some of which are in standard clinical practice, and others which are less widely applied. The clinical validity and clinical utility varies extensively between tests. The variants tested are likely to have different degrees of sensitivity due to different risk allele frequencies and linkage disequilibrium patterns across populations. The clinical relevance depends on the ethnicity of the individual and variability of pharmacogenetic markers. Further research is required to determine causal variants and provide more complete assessment of drug response and side effects.Conclusion23andMe reports provide some useful pharmacogenetics information, mirroring clinical tests that are in standard use. Other tests are unspecific, providing limited guidance and may not be useful for patients without professional interpretation. Nevertheless, DTC companies like 23andMe act as a powerful intermediate step to integrate pharmacogenetic testing into clinical practice.
Selectivity matters: rules of thumb for management of plate-sized, sex-changing fish in the live reef food fish trade
Authors: Kindsvater Holly K. , Reynolds John D. , Sadovy de Mitcheson Yvonne , Mangel Marc 
Published: January 2017

AbstractEffective management of fisheries depends on the selectivity of different fishing methods, control of fishing effort, and the life history and mating system of the target species. For sex-changing species, it is unclear how the truncation of age structure or selection of specific size or age classes (by fishing for specific markets) affects population dynamics. We specifically address the consequences of plate-sized selectivity, whereby sub-mature, ‘plate-sized’ fish are preferred in the live reef food fish trade. We use an age-structured model to investigate the decline and recovery of populations fished with three different selectivity scenarios (asymptotic, dome-shaped, and plate-sized) applied to two sexual systems (female-first hermaphroditism and gonochorism). We parameterized our model with life-history data from Brown-marbled grouper (Epinephelus fuscoguttatus) and Napoleon fish (Cheilinus undulatus). ‘Plate-sized’ selectivity had the greatest negative effect on population trajectories, assuming accumulated fishing effort across ages was equal, while the relative effect of fishing on biomass was greatest with low natural mortality. Fishing such sex-changing species before maturation decreased egg production (and the spawning potential ratio) in two ways: average individual size decreased, and, assuming plasticity, females became males at a smaller size. Somatic growth rate affected biomass if selectivity was based on size-at-age because in slow growers, a smaller proportion of total biomass was vulnerable to fishing. We recommend fisheries avoid taking individuals near their maturation age, regardless of mating system, unless catch is tightly controlled. We also discuss the implications of fishing post-settlement individuals on population dynamics and offer practical management recommendations.
US foreign trade zones and import intensity examining determinants of import intensity in US foreign trade zones
Authors: Seyoum Belay 
Published: January 2017

PurposeThe paper aims to investigate the effects of several determinants of firm import intensity in US foreign trade zones (FTZs). Even though the major objective for the establishment of US FTZs is to encourage exports by facilitating the duty-free entry of imports, US firms have used it as a gateway to import goods into the US market. Currently, over 90 per cent of US FTZ output is consumed in the USA. The author examines the major determinants for such import intensity in US FTZs.Design/methodology/approachThe study is based on a survey that was conducted to explore the factors that influence import intensity of firms operating in US FTZs.FindingsThe findings reveal that besides export orientation of firms, the most promising predictors of import intensity of firms operating in USA FTZs are the policy environment in the form of inverted tariff benefits and firm business strategy.Practical implicationsThe findings are important for managers presently operating in US FTZs or intend to do so in future.Originality/valueEven though there are numerous studies on free trade zones and exports, this is the first study to examine the import intensity of US FTZs and their determinants.
Export barriers as liabilities: near perfect substitutes
Authors: Kahiya Eldrede T. 
Published: January 2017

PurposeThis study aims to use analogical reasoning to draw a conceptual link between liabilities in International Business (IB) and export barriers.Design/methodology/approachFollowing a review of 130 articles on export barriers, the study develops and applies a “liabilities” metonymy to connect the source construct (liabilities in the IB) and target subject (export barriers).FindingsLiabilities in the IB map to export barriers, and the concepts of liability of foreignness, liability of outsidership, liability of newness and liability of smallness can substitute export barriers.Practical implicationsAdoption of metonymy creates new opportunities for enhancing theory development while offering alternative perspectives regarding coping mechanisms for overcoming export barriers.Originality/valueThis, to the author’s best knowledge, is the first study in the IB to theorize based on metonymy.
Financial reporting quality of target companies and acquirer returns: evidence from Korea
Authors: Lim Joohyun , Lee Jaehong , Chang jinho 
Published: January 2017

Purpose
– This paper aims to examine the association between financial reporting quality in target companies and acquisition profitability in a sample of 280 acquisitions in South Korea between 2002 and 2011.

Design/methodology/approach
– Using the accruals quality measure developed by McNichols (2002) as a proxy for financial reporting quality, it was found that high-quality financial reporting in target companies is associated with more profitable acquisitions for the acquirer, as measured by the acquirer’s announcement returns.

Findings
– It was found that high-quality financial reporting in target companies is associated with more profitable acquisitions for the acquirer, as measured by the acquirer’s announcement returns. This finding suggests that higher-quality accounting information leads to better decision-making during acquisitions. It was also found that the importance of financial reporting quality increases when information about the target company is scarce. In addition, it was found that the financial reporting quality of target companies is less important when the agency costs of the acquirer are high.

Practical implications
– This analysis also complements several recent papers that examine target firm accounting information and mergers and acquisitions (M&A) returns (Shalev and Martin, 2009; McNichols and Stubben, 2012). By expanding this analysis, the authors help to provide a more complete understanding of how target firm’s accounting quality relates to the valuation of the target company and future expected synergies in M&A deal practice.

Originality/value
– This study is one of a growing body of literature on the relations between financial reporting quality and investment decisions (Bens and Monahan, 2004; Biddle and Hilary, 2006; Hope and Thomas, 2008; McNichols and Stubben, 2008; Biddle et al., 2009; Francis and Martin, 2010). These results extend and generalize the results of prior studies, in that data pertinent to acquisition profitability of M&As in South Korea are used.
The study of patent portfolio strategies of oil shale developers
Authors: Chang Shu-Hao , Chang Hsin-Yuan 
Published: January 2017

Purpose
The development of oil shale has become a popular technique in the energy industry in recent years. Although more research attention has been paid to this topic, there are scanty studies on patent portfolios. This study aims to explore this current mainstream technique and the patent portfolios of oil shale developers and investigates the major assignees at present to find the technical development trend of oil shale as a reference for government, policy makers, investors and industrial strategic development.

Design/methodology/approach
This study applies correspondence analysis and K-means clustering analysis on data mining and probes into the competitive techniques and strategic groups of the main enterprises in the oil shale industry. In addition, by approval dates, this study analyzes technical directions and the development trends of the current main oil shale enterprises.

Findings
The findings show differences in the enterprises regarding technical positions and patent portfolio strategies.

Originality/value
Differential positioning analysis suggests the relative technical advantages of the various enterprises and evaluates the competition among oil shale enterprises.
Influence research of multi-dimensional tech-innovation behavior on tech-innovation performance
Authors: Zhou Fu-li , Wang Xu , Lin Yun , He Yan-dong , Wu Nan 
Published: January 2017

PurposeThe purpose of this study is to investigate the research on the influence of tech-innovation behavior on tech-innovation performance for Chinese manufacturing enterprises. Environmental performance has been taken into consideration with the green manufacturing and sustainability philosophy being a hotspot.Design/methodology/approachTo verify the hypotheses and assumptions, a questionnaire was designed and a semi-structured interview was conducted for data collection. In addition, structural equation modeling (SEM) is applied to verify the influence model through assessing the fitting indexes based on the 317 questionnaire responses in the form of Likert-type scale.FindingsTech-innovation behavior and activity from direction, mode and investment behavior dimensions show their different positive influences on tech-innovation performance. This paper has creatively taken environmental tech-innovation performance into consideration, as well as economic performance. This investigation has provided the interpretation for each individual enterprise from three dimensions when conducting tech-innovation activity.Research limitations/implicationsTech-innovation behavior, which has been a subject of extended discussion during recent decades, is the effective activity or action for tech-innovation. However, there have not been any studies on the environmental performance influence study, as well as the economic performance from these three dimensions and framework.Practical implicationsAs this paper discusses the tech-innovation performance influence study from three dimensions, individual enterprises can choose the corresponding action for the proper tech-innovation path, especially for small- and medium-sized enterprises.Originality/valueThis study helps managers recognize tech-innovation activities for better tech-innovation performance based on the empirical study.
Data, information, knowledge and intelligence
Authors: Tang Victor , Yanine Fernando , Valenzuela Lionel 
Published: January 2017

PurposeThis paper is about data, information, knowledge and judgment; their definitions and their parallel cognitive dimensionalities; and it is about their implications in innovation. This paper aims to discuss and illustrate the implications of this cognitive framework on innovation science and on the ability to innovate. To that end, the authors use a progression of examples and cases to identify and discuss new challenges and predicaments in innovation.Design/methodology/approachThe authors discuss how the development of Chemistry, as a science, inspires this work. But the authors have purposely eschewed examples from mathematics or the natural sciences. Instead, the authors study business examples because they are more readily understood. However, the implications they reveal, on innovation, are no less significant. The explosive volume, complexity and requirements – for data, information, knowledge and intelligence in business – are arguably more messy, demanding and difficult. They are sociotechnical problems of unprecedented scale and qualitative change.FindingsThe authors frame their conclusion as the mega-nano hypothesis, which asserts that problems, at this new scale and qualitative difference, cannot be solved with conventional thinking and tired mental models. They obstruct the ability to innovate and impede creative thinking about theory.Originality/valueThe mega-nano hypothesis is consistent with historical trajectories in scientific development. Namely, when there are mega or nano changes of scale and frame-breaking phenomena, a new science is required to address the new and unprecedented problems that emerge.
Resources and capabilities through the lens of value (co-) creation: a literature review
Authors: França Alexandra , Ferreira João 
Published: January 2017

PurposeInvolving customers to create value is an important strategy for firms to compete, satisfy customized demands and gain competitive advantage. This potentially important alternate viewpoint for strategic management aims to widen avenues of business opportunities.Design/methodology/approachTo date in the strategy discipline, profuse research has been undertaken to identify the typology of resources/capabilities that explain firm’s unique competitiveness and superior performance. However, very little research has been undertaken to explain how firms attempt to create customer value, how resources become valuable for customers maximizing benefits and how investments in dynamic capabilities allow the firm to (co) create value. This paper is intended as a contribution to the ongoing conceptual development of resources and capabilities (RC) through the lens of value co-creation and provides initial guidance for future empirical studies.FindingsThe authors organize and integrate the diverse body of past literature relating to RC and, in doing so, develop a synthesized conceptual model. A critical interpretation of previous literature relating to RC and co-creation reveals how little attention has been paid to these connections and what exists is only partial.Originality/valueThe authors develop a first initial constructing of the past theory which is subsequently refined and strengthened into a conceptual model advancing on theoretical development in the field.
Disclosure of sexual orientation in the USA and its consequences in the workplace
Authors: Bonaventura Luigi , Biondo Alessio Emanuele 
Published: January 2017

Purpose
Discrimination and hostility in the workplace prevents homosexual workers from performing their core functions on the job. Moreover, it introduces unnecessary costs by increasing absenteeism, lowering productivity, and fostering a less motivated, less entrepreneurial, and less committed workforce. By means of an agent-based model, the authors simulated the effects on unemployment rates of an increasing of sexual orientation (SO) disclosure in the workplaces. The authors tested the effects on workers’ utility, level of job satisfaction and segregation. The results show a complessive improvement of the firms’ performances and a better job satisfaction for undeclared and homosexual workers and employers. With a homosexual employer, the authors can observe an increasing homosexual utility and firm profit, with a low decrease in undeclared utility. Instead, with an undeclared employer, the firm’s profit decreases but the total effect is positive. The paper aims to discuss these issues.

Design/methodology/approach
An agent-based model applied.

Findings
Effects of sexual disclosure on unemployment rates, job satisfaction, and job segregation.

Originality/value
The economic literature on SO and job satisfaction is very meager.
Experimental tests and numerical modelling on slender steel columns at high temperatures
Authors: Franssen Jean-Marc , Zhao Bin , Gernay Thomas 
Published: January 2017

Purpose
The purpose of this paper is to gain from experimental tests an insight into the failure mode of slender steel columns subjected to fire. The tests will also be used to validate a numerical model.

Design/methodology/approach
A series of experimental fire tests were conducted on eight full-scale steel columns made of slender I-shaped Class 4 sections. Six columns were made of welded sections (some prismatic and some tapered members), and two columns were made of hot rolled sections. The nominal length of the columns was 2.7 meters with the whole length being heated. The load was applied at ambient temperature after which the temperature was increased under constant load. The load was applied concentrically on some tests and with an eccentricity in other tests. Heating was applied by electrical resistances enclosed in ceramic pads. Numerical simulations were performed with the software SAFIR® using shell elements.

Findings
The tests have allowed determining the appropriate method of application of the electrical heating system for obtaining a uniform temperature distribution in the members. Failure of the columns during the tests occurred by combination of local and global buckling. The numerical model reproduced correctly the failure modes as well as the critical temperatures.

Originality/value
The numerical model that has been validated has been used in subsequent parametric analyses performed to derive design equations to be used in practice. This series of test results can be used by the scientific community to validate their own numerical or analytical models for the fire resistance of slender steel columns.
A modified household economic portfolio model for assessing impact of microfinance using diaries
Authors: Alia Hayyan , Ashta Arvind , Ratsimalahelo Zaka 
Published: January 2017

Purpose
Microfinance impact evaluation studies help in discovering client needs which are diverse, special and different from the needs of the conventional bankable clients. Thus, such area of market research is becoming essential for microfinance institutions for designing better client-centred products. In this research, the authors discuss the specific model of household economic portfolio (HEP) for qualitative impact evaluation in microfinance. The paper aims to discuss the complexity limitations of the HEP. Solutions are provided for overcoming these limitations. The modified household economic portfolio (M-HEP) model is simplified and detailed, and two types of diaries are suggested for implementing it.

Design/methodology/approach
First, the authors briefly review the literature on impact assessment methods in microfinance and on the HEP model. In the second part of the paper, the M-HEP is suggested and discussed in detail. In the third part, the authors present a case study to illustrate the additional information that can be generated by using our suggested research tool and model. Finally, the authors wrap up with a summary of the findings.

Findings
Solutions are provided for overcoming the limitations of the HEP model. The suggested model (M-HEP) is simplified and detailed, and two types of diaries are suggested for implementing it. The case study shows that, certainly, time and money are related. While time may mean money for a rich person, for a poor person, if money is not forthcoming, she may spend time on non-income generating work that adds to her social esteem. She may also consume inexpensive assets because spending time at low cost is important. Finally, she spends time in conducting activities for which she cannot afford to pay.

Originality/value
The paper offers two novelties. First, it details the interactions between the elements of the HEP model of Chen and Dunn. This improvement to the original model is highly important for defining the measures that are required for redrawing the economic portfolio of an individual. The second novelty is in suggesting the collection of time-use and financial daily data. To the best of our knowledge, this is the first time a combined diary is used in microfinance research. These two novelties allow the application of a modified version of the highly interesting HEP model in spite of its complexity.
Service quality and customer satisfaction in thermal tourism
Authors: Silvestri Cecilia , Aquilani Barbara , Ruggieri Alessandro 
Published: January 2017

Purpose
Satisfaction in the tourism sector is a highly sensitive subject, and customer satisfaction (CS) has a significant impact on the choice of destinations made by tourists and on the decision to recommend them to friends or acquaintances. The purpose of this paper is to give empirical evidence of the dimensions of service quality (technical, functional and company image (CI)) and their connections in the sector of thermal tourism. It also aims at investigating the CI, seeking to understand whether some of the technical and functional service quality variables play a role in determining it.

Design/methodology/approach
An empirical survey was conducted by administering a structured research questionnaire in order to collect all necessary data, which was then elaborated to test the hypotheses using factor and multiple regression analyses.

Findings
The results of the survey confirm the direct impact of service quality dimensions (technical, functional and CI) on CS also in the thermal sector when considered individually. Moreover, when the CI was analyzed further, relational quality was found to be dependent on thermal employees’ capabilities, abilities, trustworthiness, availability, etc. Finally, when considered together, functional service quality and CI have a stronger effect on CS than technical service quality.

Originality/value
The originality of the present research relies on the following: a further contribution to the so-called “European perspective” of service quality; the study of service quality dimensions (technical, functional and CI) in the thermal sector; and evidencing the link between thermal employee characteristics and the relational quality factor of the CI, demonstrating that many aspects of this construct need further empirical investigation, in the wellness sector.