bluuebunny/crossref_metadata_2025_split huggingface dataset:
Photometric variability of the Be star population with the KELT survey
Authors: Labadie-Bartz Jonathan , Pepper Joshua , Chojnowski S. Drew , McSwain M. Virginia 
Published: July 2017

AbstractWe are using light curves from the KELT exoplanet transit survey (Pepper et al. 2007) to study the variability of hundreds of Be stars. Combining these light curves with simultaneous time-series spectra from the APOGEE survey (Majewski et al. 2015) provides a glimpse into how changes in the circumstellar environment are correlated to brightness variations.
Helium stars: Towards an understanding of Wolf–Rayet evolution
Authors: McClelland Liam A. S. , Eldridge J. J. 
Published: July 2017

AbstractRecent observational modelling of the atmospheres of hydrogen-free Wolf–Rayet stars have indicated that their stellar surfaces are cooler than those predicted by the latest stellar evolution models. We have created a large grid of pure helium star models to investigate the dependence of the surface temperatures on factors such as the rate of mass loss and the amount of clumping in the outer convection zone. Upon comparing our results with Galactic and LMC WR observations, we find that the outer convection zones should be clumped and that the mass-loss rates need to be slightly reduced. We discuss the implications of these findings in terms of the detectability of Type Ibc supernovae progenitors, and in terms of refining the Conti scenario.
Primary School Students’ Implicit Theories and Their Reading	Motivation
Authors: Hellmich Frank , Hoya Fabian 
Published: July 2017

Abstract. Parents’ and teachers’ effort feedback is considered to be an important prerequisite for children’s implicit theories of intelligence and their academic self-concepts as well as for their learning and achievement motivation. Therefore, our study examines whether differences in N = 685 primary school students’ implicit theories, their reading self-concepts, and their reading motivation can be predicted by their perceptions of their parents’ and teachers’ effort feedback on reading processes. The results of a structural equation model show that children’s perceptions of their parents’ effort feedback predict their implicit theories, their reading self-concepts, and their reading motivation. The correlation between children’s perceived parental effort feedback and their intrinsic reading motivation is mediated by their implicit theories. Children’s implicit theories and their reading motivation cannot be predicted by their perceptions of their teachers’ effort feedback.
53-attosecond X-ray pulses reach the carbon K-edge
Authors: Li Jie , Ren Xiaoming , Yin Yanchun , Zhao Kun , Chew Andrew , Cheng Yan , Cunningham Eric , Wang Yang , Hu Shuyuan , Wu Yi , Chini Michael , Chang Zenghu 
Published: July 2017

AbstractThe motion of electrons in the microcosm occurs on a time scale set by the atomic unit of time—24 attoseconds. Attosecond pulses at photon energies corresponding to the fundamental absorption edges of matter, which lie in the soft X-ray regime above 200 eV, permit the probing of electronic excitation, chemical state, and atomic structure. Here we demonstrate a soft X-ray pulse duration of 53 as and single pulse streaking reaching the carbon K-absorption edge (284 eV) by utilizing intense two-cycle driving pulses near 1.8-μm center wavelength. Such pulses permit studies of electron dynamics in live biological samples and next-generation electronic materials such as diamond.
Predictive modeling of Time-Temperature-Transformation diagram of metallic glasses based on atomistically-informed classical nucleation theory
Authors: Sato Yuji , Nakai Chiaki , Wakeda Masato , Ogata Shigenobu 
Published: July 2017

AbstractTheoretical prediction of glass forming ability (GFA) of metallic alloys is a key process in exploring metallic alloy compositions with excellent GFA and thus with the ability to form a large-sized bulk metallic glass. Molecular dynamics (MD) simulation is a promising tool to achieve a theoretical prediction. However, direct MD prediction continues to be challenging due to the time-scale limitation of MD. With respect to practical bulk metallic glass alloys, the time necessary for quenching at a typical cooling rate is five or more orders of magnitude higher than that at the MD time-scale. To overcome the time-scale issue, this study proposes a combined method of classical nucleation theory and MD simulations. The method actually allows to depict the time-temperature-transformation (TTT) diagram of the bulk metallic glass alloys. The TTT directly provides a prediction of the critical cooling rate and GFA. Although the method assumes conventional classical nucleation theory, all the material parameters appearing in the theory were determined by MD simulations using realistic interatomic potentials. The method is used to compute the TTT diagrams and critical cooling rates of two Cu-Zr alloy compositions (Cu50Zr50 and Cu20Zr80). The results indicate that the proposed method reasonably predicts the critical cooling rate based on the computed TTT.
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1
Authors: Alsøe Lene , Sarno Antonio , Carracedo Sergio , Domanska Diana , Dingler Felix , Lirussi Lisa , SenGupta Tanima , Tekin Nuriye Basdag , Jobert Laure , Alexandrov Ludmil B. , Galashevskaya Anastasia , Rada Cristina , Sandve Geir Kjetil , Rognes Torbjørn , Krokan Hans E. , Nilsen Hilde 
Published: July 2017

AbstractBoth a DNA lesion and an intermediate for antibody maturation, uracil is primarily processed by base excision repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective monofunctional uracil DNA glycosylase (SMUG1). The relativein vivocontributions of each glycosylase remain elusive. To assess the impact of SMUG1 deficiency, we measured uracil and 5-hydroxymethyluracil, another SMUG1 substrate, inSmug1−/−mice. We found that 5-hydroxymethyluracil accumulated inSmug1−/−tissues and correlated with 5-hydroxymethylcytosine levels. The highest increase was found in brain, which contained about 26-fold higher genomic 5-hydroxymethyluracil levels than the wild type.Smug1−/−mice did not accumulate uracil in their genome andUng−/−mice showed slightly elevated uracil levels. Contrastingly,Ung−/−Smug1−/−mice showed a synergistic increase in uracil levels with up to 25-fold higher uracil levels than wild type. Whole genome sequencing of UNG/SMUG1-deficient tumours revealed that combined UNG and SMUG1 deficiency leads to the accumulation of mutations, primarily C to T transitions within CpG sequences. This unexpected sequence bias suggests that CpG dinucleotides are intrinsically more mutation prone. In conclusion, we showed that SMUG1 efficiently prevent genomic uracil accumulation, even in the presence of UNG, and identified mutational signatures associated with combined UNG and SMUG1 deficiency.
Calibration of multi-layered probes with low/high magnetic moments
Authors: Panchal Vishal , Corte-León Héctor , Gribkov Boris , Rodriguez Luis Alfredo , Snoeck Etienne , Manzin Alessandra , Simonetto Enrico , Vock Silvia , Neu Volker , Kazakova Olga 
Published: July 2017

AbstractWe present a comprehensive method for visualisation and quantification of the magnetic stray field of magnetic force microscopy (MFM) probes, applied to the particular case of custom-made multi-layered probes with controllable high/low magnetic moment states. The probes consist of two decoupled magnetic layers separated by a non-magnetic interlayer, which results in four stable magnetic states: ±ferromagnetic (FM) and ±antiferromagnetic (A-FM). Direct visualisation of the stray field surrounding the probe apex using electron holography convincingly demonstrates a striking difference in the spatial distribution and strength of the magnetic flux in FM and A-FM states. In situ MFM studies of reference samples are used to determine the probe switching fields and spatial resolution. Furthermore, quantitative values of the probe magnetic moments are obtained by determining their real space tip transfer function (RSTTF). We also map the local Hall voltage in graphene Hall nanosensors induced by the probes in different states. The measured transport properties of nanosensors and RSTTF outcomes are introduced as an input in a numerical model of Hall devices to verify the probe magnetic moments. The modelling results fully match the experimental measurements, outlining an all-inclusive method for the calibration of complex magnetic probes with a controllable low/high magnetic moment.
NuBBEDB: an updated database to uncover chemical and biological information from Brazilian biodiversity
Authors: Pilon Alan C. , Valli Marilia , Dametto Alessandra C. , Pinto Meri Emili F. , Freire Rafael T. , Castro-Gamboa Ian , Andricopulo Adriano D. , Bolzani Vanderlan S. 
Published: July 2017

AbstractThe intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and products beneficial to human well-being. To uncover the chemistry of Brazilian natural products, the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) was created as the first natural product library from Brazilian biodiversity. Since its launch in 2013, the NuBBEDB has proven to be an important resource for new drug design and dereplication studies. Consequently, continuous efforts have been made to expand its contents and include a greater diversity of natural sources to establish it as a comprehensive compendium of available biogeochemical information about Brazilian biodiversity. The content in the NuBBEDB is freely accessible online (https://nubbe.iq.unesp.br/portal/nubbedb.html) and provides validated multidisciplinary information, chemical descriptors, species sources, geographic locations, spectroscopic data (NMR) and pharmacological properties. Herein, we report the latest advancements concerning the interface, content and functionality of the NuBBEDB. We also present a preliminary study on the current profile of the compounds present in Brazilian territory.
Environmental influence on Pristionchus pacificus mouth form through different culture methods
Authors: Werner Michael S. , Sieriebriennikov Bogdan , Loschko Tobias , Namdeo Suryesh , Lenuzzi Masa , Dardiry Mohannad , Renahan Tess , Sharma Devansh Raj , Sommer Ralf J. 
Published: July 2017

AbstractEnvironmental cues can impact development to elicit distinct phenotypes in the adult. The consequences of phenotypic plasticity can have profound effects on morphology, life cycle, and behavior to increase the fitness of the organism. The molecular mechanisms governing these interactions are beginning to be elucidated in a few cases, such as social insects. Nevertheless, there is a paucity of systems that are amenable to rigorous experimentation, preventing both detailed mechanistic insight and the establishment of a generalizable conceptual framework. The mouth dimorphism of the model nematode Pristionchus pacificus offers the rare opportunity to examine the genetics, genomics, and epigenetics of environmental influence on developmental plasticity. Yet there are currently no easily tunable environmental factors that affect mouth-form ratios and are scalable to large cultures required for molecular biology. Here we present a suite of culture conditions to toggle the mouth-form phenotype of P. pacificus. The effects are reversible, do not require the costly or labor-intensive synthesis of chemicals, and proceed through the same pathways previously examined from forward genetic screens. Different species of Pristionchus exhibit different responses to culture conditions, demonstrating unique gene-environment interactions, and providing an opportunity to study environmental influence on a macroevolutionary scale.
Chemotherapy treatment induces an increase of autophagy in the luminal breast cancer cell MCF7, but not in the triple-negative MDA-MB231
Authors: Garbar Christian , Mascaux Corinne , Giustiniani Jérôme , Merrouche Yacine , Bensussan Armand 
Published: July 2017

AbstractAutophagy is one of the chemotherapy resistance mechanisms in breast cancer. The aim of this study was to determine the level of recruitment of the autophagy pathway in the triple-negative breast cancer (TNBC) cell line MDA-MB231 compared with that in the control luminal breast cancer cell line MCF7 before and after treatment with chemotherapy drugs. Furthermore, we investigated the relationship between autophagy and EGFR, MUC1 and IL17-receptors as activators of autophagy. Immunohistochemistry was performed in cell culture blocks using LC3b, MUC1-C, EGFR, IL17A, IL17-RA and IL17-RB antibodies. We found that the basal autophagy level in MDA-MB231 was high, whereas it was low in MCF7. However, in contrast to MDA-MB231, the autophagy level was increased in MCF7 upon treatment with chemotherapy agents. Interestingly, we observed that the expression levels of MUC1-C, EGFR, IL17-RA, and IL17-RB were not modified by the same treatments. Furthermore, the chemotherapy treatments did not increase autophagy in TNBC cells without affecting the expression levels of MUC1-C, EGFR, IL17-RA or IL17-RB.
Broadband Silicon-On-Insulator directional couplers using a combination of straight and curved waveguide sections
Authors: Chen George F. R. , Ong Jun Rong , Ang Thomas Y. L. , Lim Soon Thor , Png Ching Eng , Tan Dawn T. H. 
Published: July 2017

AbstractBroadband Silicon-On-Insulator (SOI) directional couplers are designed based on a combination of curved and straight coupled waveguide sections. A design methodology based on the transfer matrix method (TMM) is used to determine the required coupler section lengths, radii, and waveguide cross-sections. A 50/50 power splitter with a measured bandwidth of 88 nm is designed and fabricated, with a device footprint of 20 μm × 3 μm. In addition, a balanced Mach-Zehnder interferometer is fabricated showing an extinction ratio of >16 dB over 100 nm of bandwidth.
Dual-specificity tyrosine-phosphorylation regulated kinase 1A Gene Transcription is regulated by Myocyte Enhancer Factor 2D
Authors: Wang Pin , Wang Luanluan , Chen Long , Sun Xiulian 
Published: July 2017

AbstractDual-specificity tyrosine–phosphorylation regulated kinase 1A (DYRK1A) is localized in the Down syndrome critical region of chromosome 21. As a candidate gene responsible for learning defects associated with Down syndrome and Alzheimer’s disease (AD), DYRK1A has been implied to play pivotal roles in cell proliferation and brain development. MEF2D, a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors, was proved to be in control of neuronal cell differentiation and development. Here we demonstrated that MEF2D could upregulate DYRK1A gene expression through specific activation of DYRK1A isoform 5 gene transcription. A MEF2D responsive element from −268 to −254 bp on promoter region of DYRK1A isoform 5 was identified and confirmed by luciferase assay, electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP). The coordinated expression of DYRK1A and MEF2D in mouse brain development indicated a possibility of the cross-interaction of these two genes during neurodevelopment. The DYRK1A kinase activity was also affected by MEF2D’s transcriptional regulation of DYRK1A. Therefore, the molecular regulation of DYRK1A by MEF2D further supported their involvement in neurodevelopment.
FT-IR-based method for rutin, quercetin and quercitrin quantification in different buckwheat (Fagopyrum) species
Authors: Kokalj Ladan Meta , Straus Janka , Tavčar Benković Eva , Kreft Samo 
Published: July 2017

AbstractThe present study explores an alternative method for antioxidants determination in buckwheat (Fagopyrum) samples. Buckwheat contains different amounts of the antioxidants rutin, quercetin and quercitrin in different plant parts. Buckwheat seeds are most commonly used as food; however, preparations from the herb can also be used as a rich source of rutin. Infrared spectroscopy was used for individual and sum quantification of rutin, quercetin and quercitrin in whole and ground flowers and leaves of seven different buckwheat species. Correlation coefficients R of calibration and independent validation set for rutin, quercetin and quercitrin were 1.00 and 0.98, 0.94 and 0.99, 0.99 and 0.95, respectively. Some of the developed models had accuracy comparable to the reference HPLC method. Additionally many different parameters that give an important insight into the FTIR technique are discussed (different plant parts, whole and ground untreated samples, 3 different resolutions, 7 spectra pre-treatments, using individual or averaged spectra, reducing spectral data input, considering additional non-spectral data). The implemented technique used no sample preparation, is non-destructive and uses very little amounts of sample. Result show that infrared spectroscopy can be a fast and environmentally friendly alternative technique for routine analysis of main flavonoids in aerial parts of buckwheat.
Liquid metal amoeba with spontaneous pseudopodia formation and motion capability
Authors: Hu Liang , Yuan Bin , Liu Jing 
Published: July 2017

AbstractThe unique motion of amoeba with a deformable body has long been an intriguing issue in scientific fields ranging from physics, bionics to mechanics. So far, most of the currently available artificial machines are still hard to achieve the complicated amoeba-like behaviors including stretching pseudopodia. Here through introducing a multi-materials system, we discovered a group of very unusual biomimetic amoeba-like behaviors of self-fueled liquid gallium alloy on the graphite surface immersed in alkaline solution. The underlying mechanisms were discovered to be the surface tension variations across the liquid metal droplet through its simultaneous electrochemical interactions with aluminum and graphite in the NaOH electrolyte. This finding would shed light on the packing and the structural design of future soft robots owning diverse deformation capability. Moreover, this study related the physical transformation of a non-living LM droplet to the life behavior of amoeba in nature, which is inspiring in human’s pursuit of advanced biomimetic machine.
Antimalarial troponoids, puberulic acid and viticolins; divergent synthesis and structure-activity relationship studies
Authors: Sennari Goh , Saito Ryo , Hirose Tomoyasu , Iwatsuki Masato , Ishiyama Aki , Hokari Rei , Otoguro Kazuhiko , Ōmura Satoshi , Sunazuka Toshiaki 
Published: July 2017

AbstractDivergent synthesis of antimalarial troponoids, including naturally occurring compounds, some of which were identified and isolated by our group, has been achieved utilizing the total synthetic route of puberulic acid. Structure-activity relationships of natural products and simple troponoids inspired us to explore more detailed properties of this class of compounds. Access to new derivatives was facilitated through intermediate compounds generated during the total synthesis of puberulic acid by a stepwise oxidation-aromatization sequence to provide 7-hydroxytropolones and bromination for conversion of the carboxylic acid moiety. The first total synthesis of viticolin A, as well as the synthesis of different methyl-substituted derivatives, has also been achieved. In vitro antimalarial activity and cytotoxicity of novel derivatives were evaluated and fundamental information to facilitate the discovery of more promising antimalarials was obtained.
A Post-Processing Method for Three-Dimensional Electrical Impedance Tomography
Authors: Martin Sébastien , Choi Charles T. M. 
Published: July 2017

AbstractElectrical impedance tomography is a modern biomedical imaging method. Its goal is to image the electrical properties of human tissues. This approach is safe for the patient’s health, is non-invasive and has no known hazards. However, the approach suffers from low accuracy. Linear inverse solvers are commonly used in medical applications, as they are strongly robust to noise. However, linear methods can give only an approximation of the solution that corresponds to a linear perturbation from an initial estimate. This paper proposes a novel reconstruction process. After applying a linear solver, the conductivity distribution is post-processed with a nonlinear algorithm, with the aim of reproducing the abrupt change in conductivity at the boundaries between tissues or organs. The results are used to compare the proposed method with three other widely used methods. The proposed method offers higher quality images and a higher robustness to noise, and significantly reduces the error associated with image reconstruction.
Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients
Authors: Xiao Fei-Yan , Luo Jian-Quan , Liu Min , Chen Bi-Lian , Cao Shan , Liu Zhao-Qian , Zhou Hong-Hao , Zhou Gan , Zhang Wei 
Published: July 2017

AbstractCarboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite. The effects of CES1 S75N (rs2307240,C>T) on clopidogrel response among 851 acute coronary syndrome patients who came from the north, central and south of China were studied. The occurrence ratios of each endpoint in the CC group were significantly higher than in the CT + TT group for cerebrovascular events (14% vs 4.8%, p < 0.001, OR = 0.31), acute myocardial infarction (15.1% vs 6.1%, p < 0.001, OR = 0.37) and unstable angina (62.8% vs 37.7%, p < 0.001, OR = 0.36). The results showed that there was a significant association between CES1 S75N (rs2307240) and the outcome of clopidogrel therapy. Moreover, the frequency of the T allele of rs2307240 in acute coronary syndrome patients (MAF = 0.22) was more than four times higher than that in the general public (MAF = 0.05).
Separate requirements for detection and perceptual stability of motion in interocular suppression
Authors: Ananyev Egor , Penney Trevor B. , Hsieh Po-Jang 
Published: July 2017

AbstractIn interocular masking, a stimulus presented to one eye (the mask) is made stronger in order to suppress from awareness the target stimulus presented to the other eye. We investigated whether matching the features of the target and the mask would lead to more effective suppression (feature-selective suppression), or not (i.e., non-selective suppression). To control the temporal characteristics of the stimuli, we used a dynamic interocular mask to suppress a moving target, and found that neither matching speed nor pattern of motion led to more effective suppression. Instead, a faster target was detected faster, regardless of the mask type or speed, while a relatively slow (about 1°/s) mask was more perceptually stable (i.e., maintained suppression longer) in a non-selective fashion. While the requirement for target detectability, i.e., salience, is well characterized, relatively little attention is given to the factors that make a mask percept more perceptually stable. Based on these results, we argue that there are separate requirements for detection and perceptual stability.