bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migratory Behavior and Physiological Development as Potential Determinants of Life History Diversity in Fall Chinook Salmon in the Clearwater River
Authors: Tiffan Kenneth F. , Kock Tobias J. , Connor William P. , Richmond Marshall C. , Perkins William A. 
Published: January 2018

AbstractWe studied the influence of behavior, water velocity, and physiological development on the downstream movement of subyearling fall‐run Chinook Salmon Oncorhynchus tshawytscha in both free‐flowing and impounded reaches of the Clearwater and Snake rivers as potential mechanisms that might explain life history diversity in this stock. Movement rates and the percentage of radio‐tagged fish that moved faster than the average current velocity were higher in the free‐flowing Clearwater River than in impounded reaches. This supports the notion that water velocity is a primary determinant of downstream movement regardless of a fish's physiological development. In contrast, movement rates slowed and detections became fewer in impounded reaches, where water velocities were much lower. The percentage of fish that moved faster than the average current velocity continued to decline and reached zero in the lowermost reach of Lower Granite Reservoir, suggesting that the behavioral disposition to move downstream was low. These findings contrast with those of a similar, previous study of Snake River subyearlings despite similarity in hydrodynamic conditions between the two studies. Physiological differences between Snake and Clearwater River migrants shed light on this disparity. Subyearlings from the Clearwater River were parr‐like in their development and never showed the increase in gill Na+/K+‐ATPase activity displayed by smolts from the Snake River. Results from this study provide evidence that behavioral and life history differences between Snake and Clearwater River subyearlings may have a physiological basis that is modified by environmental conditions.
Investigating Pregnancy Outcomes After Abnormal Cell‐Free DNA Test Results
Authors: Lu Jessica , Saller Devereux N. , Fraer Luanne M. , Chen Beatrice A. 
Published: January 2018

AbstractCell‐free DNA (cfDNA) testing has increased sensitivity and specificity compared to other prenatal screening methods, but invasive diagnostic testing (IDT) is recommended for confirmation. We performed a retrospective chart review of 39 women with abnormal cfDNA results between March 2012 and September 2015 at an urban academic hospital to evaluate patient choice and pregnancy outcomes. We analyzed data using descriptive statistics, Fisher's exact tests, and Wilcoxon rank‐sum tests. Median maternal age was 36.0 years [interquartile range (IQR) 31, 39]; 64.1% of women (25/39) were advanced maternal age and 69.2% (27/39) had abnormal ultrasounds. Median gestational age at time of cfDNA testing was 18 3/7 weeks [IQR 12 2/7, 20 5/7]. cfDNA results included trisomy 21 (89.7%, 35/39), trisomy 18 (7.7%, 3/39), and both trisomy 21/monosomy X (2.6%, 1/39). Of 39 women, 22 (56.4%) continued and 10 (25.6%) terminated the pregnancy; six (15.4%) had fetal demises, and one was lost to follow‐up. Of women continuing their pregnancies, 54.6% (12/22) declined further genetic counseling, and 77.3% (17/22) declined IDT. Only 14 women pursued IDT; not pursuing IDT was associated with continuing the pregnancy (Fisher's exact test, p = .001). All women terminating their pregnancy (90.0%, 9/10) pursued IDT or had major anomalies on ultrasound, suggesting that women considering termination undergo more confirmatory tests or already have high suspicion for an abnormal pregnancy.
Disaster Preparedness in Primary Care: Ready or Not?
Authors: Hashikawa Micheleen , Gold Katherine J. 
Published: January 2018

AbstractPurposeTo assess perceptions and attitudes toward disasters and disaster planning among outpatient primary care leaders.MethodsWritten surveys and semi-structured interviews of non-physician clinical managers and physician medical directors were conducted using the 2009 H1N1 pandemic as a case-based scenario at 5 university-affiliated family medicine clinics. Domains assessed included perceived pandemic threat; value, existence, and barriers to creating personal disaster plans; staff absenteeism estimates; barriers to work attendance. Quantitative and qualitative data were analyzed using descriptive statistics and content analysis with identification and coding of common themes, respectively.ResultsAll 12 invited leaders participated and believed a personal disaster plan was important but only 2 had plans. None had ever discussed with their staff the importance of having a personal disaster plan. Two common barriers in creating a plan were low threat perception level and never considering the possibility of pandemic influenza. Only half of respondents could list common barriers preventing staff from working. Staff were confident employees would come to work during a disaster.ConclusionOutpatient primary care leaders may hold misconceptions regarding future disasters, underestimate their potential impact on clinics, and lack personal preparedness. Further investigation and interventions are needed to ensure clinics can be prepared so they can function and help hospital and emergency services when disasters strike. (Disaster Med Public Health Preparedness. 2018;12:644–648)
Use of the Community Assessment for Public Health Response (CASPER) Method by Public Health Agencies in Texas, 2001-2015
Authors: Cross Kayla , Horney Jennifer A. 
Published: January 2018

AbstractObjectivesThe use of the Community Assessment for Public Health Emergency Response (CASPER) method in disaster and non-disaster settings continues to grow. While CASPERs flexibility has been well demonstrated, the documentation of specific actions that have resulted from the utilization of CASPER data has been limited. We attempted to document changes in emergency preparedness planning and policy based on CASPER data.MethodsWritten reports from 19 CASPERs conducted in Texas between 2001 and 2015 were collected. Key informant interviews were conducted with 9 public health staff knowledgeable about the CASPERs. Written reports and interview transcripts were coded and analyzed for themes.ResultsFew specific outcomes could be documented beyond a single successful grant application. Respondents felt CASPER data was not duplicative and was useful for improving existing plans. CASPER is seen as an effective way to enhance relationships with communities and partnerships with agencies including Emergency Management.ConclusionAs the use of CASPER grows, it is increasingly important to document any specific and measurable benefits, actions, and changes to planning or policy taken as the result of data collected using the CASPER method. Without measurable outputs and outcomes, support for the use of CASPER from decision-makers may begin to wane. (Disaster Med Public Health Preparedness. 2018;12:680-684)
PUBLIC REASON'S CHAOS THEOREM
Authors: Kogelmann Brian 
Published: January 2018

ABSTRACTCitizens in John Rawls's well-ordered society face an assurance dilemma. They wish to act justly only if they are reasonably sure their fellow citizens will also act justly. According to Rawls, this assurance problem is solved through public reasoning. This paper argues that public reason cannot serve this function. It begins by arguing that one kind of incompleteness public reason faces that most Rawlsians grant is ubiquitous but unproblematic from a normative standpoint is problematic from an assurance perspective: it makes it possible for citizens to argue for policy conclusions that are favored by their private interests, rather than justice. In response, perhaps the thing to do is structure deliberative democratic institutions such that citizens will always be incentivized to use public reasons to only argue for conclusions they believe are favored by justice. The paper proves that this is impossible by extending the Gibbard–Satterthwaite theorem.
Hospital Water Management Programs for Legionella Prevention, Minnesota, 2017
Authors: Danila Richard N. , Koranteng Nadia , Como-Sabetti Kathy J. , Robinson Trisha J. , Laine Ellen S. 
Published: January 2018

AbstractInfection preventionists at Minnesota hospitals were surveyed to determine whether they had Legionella water management plans. Of 137 hospitals, 84 (61%) responded. Among them, 27% hospitals had a water management plan, 21% regularly sampled for Legionella, and 51% had knowledge of ASHRAE Legionella prevention standards. Significant changes are needed to protect patients from nosocomial infection.Infect Control Hosp Epidemiol 2018;39:336–338
A rare cause of cyanosis in newborns: arteriovenous fistula between the right pulmonary artery and the left atrium and its treatment
Authors: Yakut Kahraman , Varan Birgul , Ozkan Murat 
Published: January 2018

AbstractThe formation of a fistula between the right pulmonary artery and the left atrium via a sac is a very rare cyanotic congenital cardiopulmonary defect. A fistula between the pulmonary artery and left atrium may cause cardiac failure in utero. It can safely be treated surgically and in selected cases closure can be performed with transcatheter insertion of a device. In this article, we present a case with a fistula between the right pulmonary artery and the left atrium that was considered unsuitable for transcatheter closure and was safely treated surgically.
Verbal Memory Deficits in OEF/OIF/OND Veterans Exposed to Blasts at Close Range
Authors: Grande Laura J. , Robinson Meghan E. , Radigan Lauren J. , Levin Laura K. , Fortier Catherine B. , Milberg William P. , McGlinchey Regina E. 
Published: January 2018

AbstractObjectives:This study investigated the relationship between close proximity to detonated blast munitions and cognitive functioning in OEF/OIF/OND Veterans.Methods:A total of 333 participants completed a comprehensive evaluation that included assessment of neuropsychological functions, psychiatric diagnoses and history of military and non-military brain injury. Participants were assigned to a Close-Range Blast Exposure (CBE) or Non-Close-Range Blast Exposure (nonCBE) group based on whether they had reported being exposed to at least one blast within 10 meters.Results:Groups were compared on principal component scores representing the domains of memory, verbal fluency, and complex attention (empirically derived from a battery of standardized cognitive tests), after adjusting for age, education, PTSD diagnosis, sleep quality, substance abuse disorder, and pain. The CBE group showed poorer performance on the memory component. Rates of clinical impairment were significantly higher in the CBE group on select CVLT-II indices. Exploratory analyses examined the effects of concussion and multiple blasts on test performance and revealed that number of lifetime concussions did not contribute to memory performance. However, accumulating blast exposures at distances greater than 10 meters did contribute to poorer performance.Conclusions:Close proximity to detonated blast munitions may impact memory, and Veterans exposed to close-range blast are more likely to demonstrate clinically meaningful deficits. These findings were observed after statistically adjusting for comorbid factors. Results suggest that proximity to blast should be considered when assessing for memory deficits in returning Veterans. Comorbid psychiatric factors may not entirely account for cognitive difficulties. (JINS, 2018,24, 466–475)
Dietary patterns are associated with child, maternal and household-level characteristics and overweight/obesity among young Samoan children
Authors: Choy Courtney C , Wang Dongqing , Baylin Ana , Soti-Ulberg Christina , Naseri Take , Reupena Muagututia S , Thompson Avery A , Duckham Rachel L , Hawley Nicola L 
Published: January 2018

AbstractObjectiveAmong young Samoan children, diet may not be optimal: in 2015, 16·1 % of 24–59-month-olds were overweight/obese, 20·3 % stunted and 34·1 % anaemic. The present study aimed to identify dietary patterns among 24–59-month-old Samoan children and evaluate their association with: (i) child, maternal and household characteristics; and (ii) nutritional status indicators (stunting, overweight/obesity, anaemia).DesignA community-based, cross-sectional study. Principal component analysis on 117 FFQ items was used to identify empirical dietary patterns. Distributions of child, maternal and household characteristics were examined by factor score quintiles. The regression of nutritional status indicatorsv. these quintiles was performed using logistic regression models.SettingTen villages on the Samoan island of Upolu.SubjectsA convenience sample of mother–child pairs (n305).ResultsTwo dietary patterns, modern and neo-traditional, emerged. The modern pattern was loaded with ‘westernized’ foods (red meat, condiments and snacks). The neo-traditional pattern included vegetables, local starches, coconuts, fish and poultry. Following the modern diet was associated with urban residence, greater maternal educational attainment, higher socio-economic status, lower vitamin C intake and higher sugar intake. Following the neo-traditional diet was associated with rural residence, lower socio-economic status, higher vitamin C intake and lower sugar intake. While dietary patterns were not related to stunting or anaemia, following the neo-traditional pattern was positively associated with child overweight/obesity (adjusted OR=4·23, 95 % CI 1·26, 14·17, for the highest quintile,P-trend=0·06).ConclusionsFurther longitudinal monitoring and evaluation of early childhood growth and development are needed to understand the influences of early diet on child health in Samoa.
Investigations of 2,4-D and Multiple Herbicide Resistance in a Missouri Waterhemp (Amaranthus tuberculatus) Population
Authors: Shergill Lovreet S. , Barlow Blake R. , Bish Mandy D. , Bradley Kevin W. 
Published: January 2018

AbstractResearch was conducted from 2015 to 2017 to investigate the potential for 2,4-D and multiple herbicide resistance in a waterhemp [Amaranthus tuberculatus(Moq.) J. D. Sauer] population from Missouri (designated MO-Ren). In the field, visual control of the MO-Ren population with 0.56 to 4.48 kg 2,4-D ha−1ranged from 26% to 77% in 2015 and from 15% to 55% in 2016. The MO-Ren population was highly resistant to chlorimuron, with visual control never exceeding 7% either year. Estimates of the 2,4-D dose required to provide 50% visual control (I50) of the MO-Ren population were 1.44 kg ha−1compared with only 0.47 kg 2,4-D ha−1for the susceptible population. Based on comparisons to a susceptible population in dose–response experiments, the MO-Ren population was approximately 3-fold resistant to 2,4-D, and 7-, 7-, 22-, and 14-fold resistant to atrazine, fomesafen, glyphosate, and mesotrione, respectively. Dicamba and glufosinate were the only two herbicides that provided effective control of the MO-Ren population in these experiments. Examinations of multiple herbicide resistance at the individual plant level revealed that 16% of the plants of the MO-Ren population contained genes stacked for six-way herbicide resistance, and only 1% of plants were classified as resistant to a single herbicide (glyphosate). Results from these experiments confirm that the MO-RenA. tuberculatuspopulation is resistant to 2,4-D, atrazine, chlorimuron, fomesafen, glyphosate, and mesotrione, making this population the third 2,4-D–resistantA. tuberculatuspopulation identified in the United States, and the first population resistant to six different herbicidal modes of action.
Locality and diel cycling of viral production revealed by a 24 h time course cross-omics analysis in a coastal region of Japan
Authors: Yoshida Takashi , Nishimura Yosuke , Watai Hiroyasu , Haruki Nana , Morimoto Daichi , Kaneko Hiroto , Honda Takashi , Yamamoto Keigo , Hingamp Pascal , Sako Yoshihiko , Goto Susumu , Ogata Hiroyuki 
Published: January 2018

Abstract
Viruses infecting microorganisms are ubiquitous and abundant in the ocean. However, it is unclear when and where the numerous viral particles we observe in the sea are produced and whether they are active. To address these questions, we performed time-series analyses of viral metagenomes and microbial metatranscriptomes collected over a period of 24 h at a Japanese coastal site. Through mapping the metatranscriptomic reads on three sets of viral genomes ((i) 878 contigs of Osaka Bay viromes (OBV), (ii) 1766 environmental viral genomes from marine viromes, and (iii) 2429 reference viral genomes), we revealed that all the local OBV contigs were transcribed in the host fraction. This indicates that the majority of viral populations detected in viromes are active, and suggests that virions are rapidly diluted as a result of diffusion, currents, and mixing. Our data further revealed a peak of cyanophage gene expression in the afternoon/dusk followed by an increase of genomes from their virions at night and less-coherent infectious patterns for viruses putatively infecting various groups of heterotrophs. This suggests that cyanophages drive the diel release of cyanobacteria-derived organic matter into the environment and viruses of heterotrophic bacteria might have adapted to the population-specific life cycles of hosts.
Identification of microRNA signature in the progression of gestational trophoblastic disease
Authors: Zhao Jiu-Ru , Cheng Wei-Wei , Wang Ya-Xin , Cai Mei , Wu Wei-Bin , Zhang Hui-Juan 
Published: January 2018

AbstractGestational trophoblastic disease (GTD) encompasses a range of trophoblast-derived disorders. The most common type of GTD is hydatidiform mole (HM). Some of HMs can further develop into malignant gestational trophoblastic neoplasia (GTN). Aberrant expression of microRNA (miRNA) is widely reported to be involved in the initiation and progression of cancers. MiRNA expression profile also has been proved to be the useful signature for diagnosis, staging, prognosis, and response to chemotherapy. Till now, the profile of miRNA in the progression of GTD has not been determined. In this study, a total of 34 GTN and 60 complete HMs (CHM) trophoblastic tissues were collected. By miRNA array screening and qRT-PCR validating, six miRNAs, including miR-370-3p, -371a-5p, -518a-3p, -519d-3p, -520a-3p, and -934, were identified to be differentially expressed in GTN vs. CHM. Functional analyses further proved that miR-371a-5p and miR-518a-3p promoted proliferation, migration, and invasion of choriocarcinoma cells. Moreover, we demonstrated that miR-371a-5p was negatively related to protein levels of its predictive target genes BCCIP, SOX2, and BNIP3L, while miR-518a-3p was negatively related to MST1 and EFNA4. For the first time, we proved that miR-371a-5p and miR-518a-3p directly targeted to 3′-UTR regions of BCCIP and MST1, respectively. Additionally, we found that miR-371a-5p and miR-518a-3p regulated diverse pathways related to tumorigenesis and metastasis in choriocarcinoma cells. The results presented here may offer new clues to the progression of GTD and may provide diagnostic biomarkers for GTN.
The inhibition of UBC13 expression and blockage of the DNMT1-CHFR-Aurora A pathway contribute to paclitaxel resistance in ovarian cancer
Authors: Zhang Xu , Feng Yan , Wang Xin-Yu , Zhang Ya-Nan , Yuan Chun-Nv , Zhang Song-Fa , Shen Yuan-Ming , Fu Yun-Feng , Zhou Cai-Yun , Li Xiao , Cheng Xiao-Dong , Lu Wei-Guo , Xie Xing 
Published: January 2018

AbstractPaclitaxel is widely used as a first-line chemotherapeutic drug for patients with ovarian cancer and other solid cancers, but drug resistance occurs frequently, resulting in ovarian cancer still presenting as the highest lethality among all gynecological tumors. Here, using DIGE quantitative proteomics, we identified UBC13 as down-regulated in paclitaxel-resistant ovarian cancer cells, and it was further revealed by immunohistochemical staining that UBC13 low-expression was associated with poorer prognosis and shorter survival of the patients. Through gene function experiments, we found that paclitaxel exposure induced UBC13 down-regulation, and the enforced change in UBC13 expression altered the sensitivity to paclitaxel. Meanwhile, the reduction of UBC13 increased DNMT1 levels by attenuating its ubiquitination, and the up-regulated DNMT1 enhanced the CHFR promoter DNA methylation levels, leading to a reduction of CHFR expression, and an increased in the levels of Aurora A. Our findings revealed a novel function for UBC13 in regulating paclitaxel sensitivity through a DNMT1-CHFR-Aurora A pathway in ovarian cancer cells. UBC13 could potentially be employed as a therapeutic molecular drug for reversing paclitaxel resistance in ovarian cancer patients.
Prolactin inhibits the progression of intervertebral disc degeneration through inactivation of the NF-κB pathway in rats
Authors: Wu Xiexing , Liu Yu , Guo Xiaobin , Zhou Wei , Wang Liangliang , Shi Jiawei , Tao Yunxia , Zhu Mo , Geng Dechun , Yang Huilin , Mao Haiqing 
Published: January 2018

AbstractIntervertebral disc degeneration (IVDD) is one of the key predisposing factors for low back pain. Although the exact mechanism remains unclear, inflammatory response and nucleus pulposus (NP) apoptosis are known to play important roles in this process. Prolactin protects against inflammation-associated chondrocyte apoptosis in arthritis. Based on prior studies, we hypothesized that prolactin might have therapeutic effects on IVDD by inhibiting the apoptosis of degenerative human disc NP cells. An experimental model of IVDD was established in 3-month-old Sprague-Dawley rats by submitting them to percutaneous disc puncture with a 20-gauge needle on levels 7–8 and 8–9 of the coccygeal vertebrae. Then the rats were injected with 20 or 200 ng prolactin on a weekly basis. Radiologic and histologic analyses were performed on days 4, 7, 14, and 28. The expression of prolactin and its receptor was analyzed in human tissue obtained from symptomatic patients undergoing microencoscopy discectomy, or from scoliosis patients undergoing deformity correction surgery. The results showed that intradiscal injection of prolactin maintained disc height and the mean signal intensity of the punctured disc. Histological analysis indicated that prolactin treatment significantly retained the complete structure of the NP and annulus fibrosus compared with the vehicle group. In addition, more collagen II, but fewer collagen I-containing tissues were detected in the prolactin treatment groups compared to the vehicle group. Moreover, low levels of tumor necrosis factor-α, interleukin-1β, cleaved-caspase 3, and TUNEL staining were observed in the prolactin treatment groups. We also demonstrated that prolactin impaired puncture-induced inflammation and cell apoptosis by downregulating activation of the NF-κB pathway. The degenerated NP tissues from patients had decreased expression of prolactin and its receptor, whereas expression was increased in the NP tissues removed from scoliosis patients. These results suggest that prolactin may be a novel therapeutic target for the treatment of IVDD.