bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction
Authors: Selvaraj Senthil , Patel Shachi , Sauer Andrew J. , McGarrah Robert W. , Jones Philip , Kwee Lydia Coulter , Windsor Sheryl L. , Ilkayeva Olga , Muehlbauer Michael J. , Newgard Christopher B. , Borlaug Barry A. , Kitzman Dalane W. , Shah Sanjiv J. , Margulies Kenneth B. , Husain Mansoor , Inzucchi Silvio E. , McGuire Darren K. , Lanfear David E. , Javaheri Ali , Umpierrez Guillermo , Mentz Robert J. , Sharma Kavita , Kosiborod Mikhail N. , Shah Svati H. 
Published: October 2024

BACKGROUND:
Mechanisms of benefit with SGLT2is (sodium-glucose cotransporter-2 inhibitors) in heart failure (HF) remain incompletely characterized. Dapagliflozin alters ketone and fatty acid metabolism in HF with reduced ejection fraction though similar effects have not been observed in HF with preserved ejection fraction. We explore whether metabolic effects of SGLT2is vary across the left ventricular ejection fraction spectrum and their relationship with cardiometabolic end points in 2 randomized trials of dapagliflozin in HF.

METHODS:
Metabolomic profiling of 61 metabolites was performed in 527 participants from DEFINE-HF (Dapagliflozin Effects on Biomarkers, Symptoms and Functional Status in Patients With HF With Reduced Ejection Fraction) and PRESERVED-HF (Dapagliflozin in PRESERVED Ejection Fraction HF; 12-week, placebo-controlled trials of dapagliflozin in HF with reduced ejection fraction and HF with preserved ejection fraction, respectively). Linear regression was used to assess changes in principal components analysis–defined metabolite factors with treatment from baseline to 12 weeks, as well as the relationship between changes in metabolite clusters and HF-related end points.

RESULTS:

The mean age was 66±11 years, 43% were female, and 33% were self-identified as Black. Two principal components analysis–derived metabolite factors (which were comprised of ketone and short-/medium-chain acylcarnitines) increased with dapagliflozin compared with placebo. Ketosis (defined as 3-hydroxybutyrate >500 μM) was achieved in 4.5% with dapagliflozin versus 1.2% with placebo (
P
=0.03). There were no appreciable treatment effects on amino acids, including branched-chain amino acids. Increases in several acylcarnitines were consistent across LVEF (
P
interaction
>0.10), whereas the ketogenic effect diminished at higher LVEF (
P
interaction
=0.01 for 3-hydroxybutyrate). Increases in metabolites reflecting mitochondrial dysfunction (particularly long-chain acylcarnitines) and aromatic amino acids and decreases in branched-chain amino acids were associated with worse HF-related outcomes in the overall cohort, with consistency across treatment and LVEF.

CONCLUSIONS:
SGLT2is demonstrate common (fatty acid) and distinct (ketogenic) metabolic signatures across the LVEF spectrum. Changes in key pathways related to fatty acid and amino acid metabolism are associated with HF-related end points and may serve as therapeutic targets across HF subtypes.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique Identifiers: NCT03030235 and NCT02653482
EPHB4-RASA1 Inhibition of PIEZO1 Ras Activation Drives Lymphatic Valvulogenesis
Authors: Chen Di , Tang Yipei , Lapinski Philip E. , Wiggins David , Sevick Eva M. , Davis Michael J. , King Philip D. 
Published: October 2024

BACKGROUND:
EPHB4 (ephrin receptor B4) and the RASA1 (p120 Ras GTPase-activating protein) are necessary for the development of lymphatic vessel (LV) valves. However, precisely how EPHB4 and RASA1 regulate LV valve development is unknown. In this study, we examine the mechanisms by which EPHB4 and RASA1 regulate the development of LV valves.

METHODS:
We used LV-specific inducible EPHB4-deficient mice and EPHB4 knockin mice that express a form of EPHB4 that is unable to bind RASA1 yet retains protein tyrosine kinase activity (EPHB4 2YP) to study the role of EPHB4 and RASA1 in LV valve development in the embryo and LV valve maintenance in adults. We also used human dermal lymphatic endothelial cells in vitro to study the role of EPHB4 and RASA1 as regulators of LV valve specification induced by oscillatory shear stress, considered the trigger for LV valve specification in vivo.

RESULTS:
LV valve specification, continued valve development postspecification, and LV valve maintenance were blocked upon induced loss of EPHB4 in LV. LV valve specification and maintenance were also impaired in EPHB4 2YP mice. Defects in LV valve development were reversed by inhibition of the Ras-MAPK (mitogen-activated protein kinase) signaling pathway. In human dermal lymphatic endothelial cells, loss of expression of EPHB4 or its ephrin b2 ligand, loss of expression of RASA1, and inhibition of physical interaction between EPHB4 and RASA1 resulted in dysregulated oscillatory shear stress–induced Ras-MAPK activation and impaired expression of LV specification markers that could be rescued by Ras-MAPK pathway inhibition. The same results were observed when human dermal lymphatic endothelial cells were stimulated with the Yoda1 agonist of the PIEZO1 oscillatory shear stress sensor. Although Yoda1 increased the number of LV valves when administered to wild-type embryos, it did not increase LV valve number when administered to EPHB4 2YP embryos.

CONCLUSIONS:
EPHB4 is necessary for LV valve specification, continued valve development postspecification, and valve maintenance. LV valve specification requires physical interaction between EPHB4 and RASA1 to limit activation of the Ras-MAPK pathway in lymphatic endothelial cells. Specifically, EPHB4-RASA1 physical interaction is necessary to dampen Ras-MAPK activation induced through the PIEZO1 oscillatory shear stress sensor. These findings reveal the mechanism by which EPHB4 and RASA1 regulate the development of LV valves.
Self-supervised representation learning for nerve fiber distribution patterns in 3D-PLI
Authors: Oberstrass Alexander , Muenzing Sascha E.A. , Niu Meiqi , Palomero-Gallagher Nicola , Schiffer Christian , Axer Markus , Amunts Katrin , Dickscheid Timo 
Published: October 2024

Abstract
A comprehensive understanding of the organizational principles in the human brain requires, among other factors, well-quantifiable descriptors of nerve fiber architecture. Three-dimensional polarized light imaging (3D-PLI) is a microscopic imaging technique that enables insights into the fine-grained organization of myelinated nerve fibers with high resolution. Descriptors characterizing the fiber architecture observed in 3D-PLI would enable downstream analysis tasks such as multimodal correlation studies, clustering, and mapping. However, best practices for observer-independent characterization of fiber architecture in 3D-PLI are not yet available. To this end, we propose the application of a fully data-driven approach to characterize nerve fiber architecture in 3D-PLI images using self-supervised representation learning. We introduce a 3D-Context Contrastive Learning (CL-3D) objective that utilizes the spatial neighborhood of texture examples across histological brain sections of a 3D reconstructed volume to sample positive pairs for contrastive learning. We combine this sampling strategy with specifically designed image augmentations to gain robustness to typical variations in 3D-PLI parameter maps. The approach is demonstrated for the 3D reconstructed occipital lobe of a vervet monkey brain. We show that extracted features are highly sensitive to different configurations of nerve fibers, yet robust to variations between consecutive brain sections arising from histological processing. We demonstrate their practical applicability for retrieving clusters of homogeneous fiber architecture, performing classification with minimal annotations and query-based retrieval of characteristic components of fiber architecture such as U-fibers.
Stress, Adaptation and Causal Pathways to Mental Health Disparities
Authors: Maltseva Kateryna 
Published: October 2024

Abstract
The present article addresses the evolutionary dimension of stress process, specifically focusing on the conceptual division into ontologically ‘ancient’ and ‘modern’ stressors. A study conducted in Kyiv, Ukraine (n = 208) in 2020 examined the relationships between both stressor types and measures of short- and long-term mental health outcomes for both positive and negative sides of mental health spectrum. Three empirical observations are noted. (1) Modern stressors but not ancient stressors had a significant effect on depression measure, despite being rated as less severe stressors by the participants. (2) Neither type of stressors was found to affect flourishing. (3) High current socioeconomic status and high degree of social cohesion attenuated the effects of modern stressors (but not that of ancient stressors) on depression; at the same time, socioeconomic status did not diminish the participants’ perceived stress levels. The theoretical implications for the adaptationist perspective on stress, mental health and health disparities are discussed.
BBNJ Agreement and Intellectual Property Implications for Marine Genetic Resources Management in ABNJ
Authors: Taghizadeh Zakieh , Asgarian Hoda 
Published: October 2024

Abstract
The new landmark BBNJ Treaty (Marine Biodiversity of Areas beyond National Jurisdiction Agreement) emphasises applying the notion of ‘common heritage of humankind’ to conserve and sustainably use marine biological diversity in areas beyond national jurisdiction (ABNJ). Existing regulatory gaps and loopholes in international law, biodiversity law, and intellectual property rights (IPR) hinder sustainable use and equitable sharing of benefits from marine genetic resources (MGRs). Effective management of MGR-based patents and digital sequence information is essential for regulating access to and use of biological materials. To foster innovation and regulate bioprospecting, a sui generis IPR regime for inventions derived from ABNJ genetic resources is necessary, potentially including regulations on MGR discoveries. This article argues that IPR considerations significantly impact commercialisation, monetary benefit-sharing from MGR utilisation, as well as the regulation of digital sequence information, capacity-building, technology transfer, and marine scientific research in ABNJ.
De-mythologizing Social Work Education: Ivan Illich Revisited
Authors: Baldwin Clive , LIU Qilin 
Published: October 2024

Abstract
Social work presents itself as a social justice profession, being concerned with the empowerment and liberation of people. Here, we argue that social work as it is instituted in programs of higher education, shares the same assumptions of need, scarcity, and la Technique as the society it criticizes, and is an iatrogenic radical monopoly. We critique these assumptions in relation to social work and social work education and then discuss the Illichian concept of conviviality on the basis of which we make suggestions for reform.
“Locked Out” of China: International Higher Education Students experiences with Involuntary Immobility during Covid-19
Authors: Hollings Stephanie , Green Benjamin J. 
Published: October 2024

Abstract
This article utilizes a dual-pronged aspirations-capabilities framework to highlight the experiences of international students that were “locked out” of China during the extent of the Covid-19 pandemic. This participatory action research (par) was conceived and supported through the collective efforts of an online student support group labelled “Students outside of China”. Through the process of collective institutional redress, students volunteered to have their experiences with involuntary immobility documented and presented within a published manuscript. As such, this research utilizes data garnered from questionnaires and in-depth interviews to answer questions of how pandemic-borne involuntary immobility impacted the ism aspirations/capabilities of China’s “locked out” ihe student population, as well as how this influenced their subsequent perceptions of China and its system of education.
The sculptor and the sculptress
Authors: Mattison Elizabeth Rice 
Published: October 2024

Abstract
The production of sculpture in the early modern Low Countries was gendered as masculine. Seventeenth-century writings about sculptors as well as mythological representations of the artform advanced this masculine notion of carving and casting. Construed as a physical craft, sculpture seemed to necessitate a strong laborer. Nevertheless, women including Anna Maria van Schurman and Maria Faydherbe earned accolades as well as notoriety for their carved works. This chapter argues that the gendered conception of sculpting presented a barrier to entry for the small number of women who worked in stone and wood; they countered this construction of production, however, in subverting expectations about their bodies, self-image, and behaviors. In transgressing conventions of femininity, women could succeed as sculptors in the Low Countries.
Weaving a business
Authors: Beerens Rudy Jos 
Published: October 2024

Abstract
This article sheds new light on the agency of women in the early modern tapestry industry by zooming in on the Amsterdam tapestry producer Clara de Hont (1664–1751). Like most women involved in tapestry making, De Hont’s history was long overshadowed by that of the men around her. She was often referred to solely as the wife or widow of Alexander Baert, with much of her art misattributed to him. This contribution breaks with this androcentric focus. Using new archival findings, it describes De Hont’s role in the establishment and management of her family’s workshop and explores the artistic and entrepreneurial choices she made to keep her business afloat. In addition, De Hont’s situation is compared to that of other women in the tapestry industry in order to emphasize the diversity of strategies that women had to use to carve out spaces for themselves and survive in a male-dominated field.
We could hardly refuse them
Authors: de Vries Anneke 
Published: October 2024

Abstract
The artist Alida Pott (1888–1931) was one of the key members of the Groninger Kunstkring (Groningen artists’ association) De Ploeg in the first years after its foundation in 1918. This contribution discusses the position of Pott and the small number of other female members within De Ploeg in the context of the usually limited role played by women in artists’ societies elsewhere in the Netherlands in the nineteenth and twentieth centuries. De Ploeg’s open-mindedness towards its female members, and the prominence of women in a variety of cultural institutions in Groningen in general at this time, is linked to the local liberal political climate. Pott’s disappearance from view after just a few years in the spotlight is usually (and convincingly) explained by the fact she simultaneously pursued a career as an art teacher, while married to fellow De Ploeg member George Martens and raising two children. However, it also prompts questions about the way female artists were treated even in a comparatively emancipated setting.
‘Impaired in life’: Analyzing people’s accounts of depression in Ethiopia – Implications for a cultural-eco social approach to global mental health
Authors: Limenih Gojjam , MacDougall Arlene , Smith Max well J , Nouvet Elysee 
Published: October 2024

Background: Depression is a global crisis and a major concern in mental health interventions, particularly in low- and middle-income countries (LMICs), where it significantly impacts disability, quality of life, and economic stability. These chronic stressors have been used to argue for scaling up the detection and treatment of depression as a public health and development priority. Aim: This study aimed to explore illness narratives of depression among patients’ and to gain insights into multifaceted suffering, its impact on persons’ lives, and help seeking. This study is part the broader study which examined global mental health, biopolitics, and depression in Ethiopia, conducted in hospice setting to explore the conception of depression in Bahirdar city, Northern Ethiopia, among patients and health care providers. In this study, we focus on patients’ accounts of depression. Method: We employed an ethnography method using in-depth interviews, fieldnotes, and observation to collect the data. A thematic analysis was used to analyze the data. Drawing from cross-cultural and critical psychiatry perspectives, we situate depression within its cultural-eco social framework. Results: The study revealed that patients’ experiences and conception of depression are deeply intertwined with Ethiopia’s sociocultural, economic, and spiritual context. Depression was often described as a state of being ‘impaired in life’, reflecting the complex interplay of individual struggles and societal pressures. Integrating quotes from patients, we demonstrated in this analysis the ways in which biographically specific challenges, societal pressures, and mental well-being are understood by study participants in accordance with Ethiopian cultural and religious norms. Conclusion: The study suggests moving beyond narrow interpretative frameworks in GMH praxis to understand and address the complex dimensions of depression in Ethiopia and similar contexts. The study advocates for a cultural-ecosocial approach to depression, emphasizing the need for mental health interventions that consider the broader social and cultural factors contributing to mental distress.
Comparing the Health Status of Immigrant and New Zealand-Born Older Adults in Aotearoa New Zealand: The Role of Socioeconomic Position
Authors: Szabó Ágnes , Goodin Rachel E. 
Published: October 2024

Objectives The study investigated the health status of older migrants relative to their New Zealand-born peers. We adopted a holistic view of health (physical, mental, and social) and a structural approach to health disparities based on migrant status and socioeconomic position. Methods Using case–control matching based on age, gender, and education, the health status of 357 older migrants and 357 New Zealand-born older adults was compared. Results Older migrants reported significantly poorer social health. Health inequities were patterned by socioeconomic status. Working class older migrants had significantly poorer physical, mental, and social health than their New Zealand-born peers. Inequities in social wellbeing persisted even at the upper end of the social gradient. Discussion Migrant background is an important social determinant of health in older age. The reduced social wellbeing of economically advantaged migrants highlights vulnerabilities regardless of socioeconomic position and the need for targeted social policies.
Study on the application amount optimization of water-based friction modifier based on field experiments
Authors: WU Bingnan , LI Jiaxin , ZHANG Shuyue , SHI Lubing , DING Haohao , LIN Qiang , WANG Wenjian , GUO Jun , ZHOU Zhongrong , LEWIS Roger , ZHOU Jianhua 
Published: October 2024

The utilization of friction modifiers (FMs) can reduce the adhesion coefficient of the top-of-rail to a moderate level, yielding a series of benefits. In this study, the influence of the FM application amount on the adhesion coefficient, noise, and braking distance was explored under field conditions. Results showed that when the FM application amount exceeded threshold values, the braking distance of the locomotive was greatly extended and the friction control performance of FM reached saturation. The FM application amount and application frequency were put forward through a simplified calculation process, which gave values of 0.33 mL/axle and 10axles/application, respectively. These application parameters achieve the desired intermediate friction level along with appropriate reductions in the noise and the lateral force.
A Realistic Ingeniously Designed Cleft Palate Simulator for Training of Residents: Bridging the Gap Between Theory and Practice
Authors: Vathulya Madhubari , Srinivasan Smruti , Kumar K Hemanth , Mohapatra Devi Prasad , Nasida Fathima N , Kapoor Akshay 
Published: October 2024

Objective Cleft palate is a congenital deformity that presents significant challenges in surgical correction. Proper training with an educational model for can greatly enhance the learning curve and improve patient outcomes. This article discusses the development and evaluation of an economical cleft palate model designed to enhance surgical skills and confidence among residents. Design The model was constructed using dental casts, acrylic resin, foam sheets, double-sided adhesives, infant feeding tubes, and red dye. Setting Tertiary care center. Participants Surgical residents. Main outcome measure The assembly time and material costs were recorded. To evaluate its effectiveness, participants’ feedbacks were collected and analyzed. Results The cleft palate model was produced at a cost of 250 INR per unit, with assembly taking approximately 15 minutes. Overall, 32 residents completed the simulation exercise of cleft surgery on the model. Participants gave the model an average score of 4 (±0.60) for realistic anatomical appearance, 3.5 (±1.3) for replicating the tactile nature of human tissue. Anatomical accuracy and ability to manipulate tissue and perform suturing received a rating of 3.4 (±1.1) and 3.7 (±0.81), respectively. The model's value as a training tool scored 4.4 (±0.51), with an overall satisfaction rating of 4.6 (±0.22) among residents. Conclusion Our cleft palate model offers an economical, practical, and accessible solution for surgical training. This model is a viable alternative to more complex and expensive training tools and potentially enhancing the training of healthcare professionals in cleft palate repair.
The Trends of Gastric Cancer in China From 1990 to 2019 and Predictions to 2040: A Bayesian Age-Period-Cohort Prediction Study
Authors: Yang Hongyu , Zhou Suya , Wang Wei , Zhao Yanrong , Qiu Yinwei , Jiang Xuewen , Lin Tianxiang , Yang Qing 
Published: October 2024

Objectives This study aims to provide the most up-to-date temporal trends in incidence, mortality, and disability-adjusted life years (DALYs) of total gastric cancer in China from 1990 to 2019, and to predict the gastric cancer trends up to 2040. Methods Data for the incidence, mortality, and DALYs of stomach cancer in China from 1990 to 2019 were extracted from Global Burden of Disease Study 2019 (GBD 2019). We conducted joinpoint regression analysis to explore possible segmented changes in gastric cancer trends. We predicted gastric cancer trends up to 2040 using a Bayesian age-period-cohort model. Results The absolute incidence, mortality, and DALYs of gastric cancer increased from 1990 to 2019 in China. However, the age-standardized rates (ASRs) of incidence, mortality, and DALYs for gastric cancer decreased between 1990 and 2019, and the reductions were more pronounced for mortality and DALYs for gastric cancer. Conclusion Our study generally reveals favorable declining trends of gastric cancer incidence and predicts that this will continue to 2040. However, the high contemporary incidence combined with China’s aging population will likely slow or even reverse the declining trend in gastric cancer mortality.