bluuebunny/crossref_metadata_2025_split huggingface dataset:
Application of Synchrotron Radiation Technologies to Electrode Materials for Li‐ and Na‐Ion Batteries
Authors: Huang Weifeng , Marcelli Augusto , Xia Dingguo 
Published: July 2017

AbstractThe search for superior‐energy‐density electrode materials for rechargeable batteries is prompted by the continuously growing demand for new electric vehicles and large energy‐storage grids. The structural properties of electrode materials affect their electrochemical performance because their functionality is correlated to their structure at the atomic scale. Although challenging, a deeper and comprehensive understanding of the basic structural operating units of electrode materials may contribute to the advancement of new energy‐storage technologies and many other technologies. Therefore, we must strategically control both the structure and kinetics of electrode materials to achieve optimal electrochemical performance. In this contribution, advancements in synchrotron radiation techniques, specifically in situ/operando experiments on electrode materials for rechargeable batteries, are presented and discussed. Indeed, the latest synchrotron radiation methods offer deeper insights into pristine and chemically modified electrode materials, opening new opportunities to optimize these materials and exploit new technologies. In particular, the most recent results from in situ/operando synchrotron radiation measurements, which play a critical role in the fundamental understanding of the kinetics processes that occur in rechargeable batteries, are discussed.
Novel spatial–temporal image correlation derived indices of tissue vascular impedance: A variability study
Authors: Wu Linda , Ferreira Ana , Stevenson Gordon N , Sanderson Jennifer , Mahajan Aditi , Meriki Neama , Welsh Alec W 
Published: July 2017

AbstractObjectives4D (3D + time) indices of tissue impedance using power Doppler (PD) ultrasound (US) can be measured with spatial–temporal image correlation (STIC) imaging. We wished to evaluate their repeatability and their influence under changes to US machine settings and regional differences within the placenta.MethodsA total of 46 healthy women were recruited at 20–34 weeks of gestation. A total of 9940 3D frames from 644 4D data sets were analysed providing both 3D and 4D indices of vascularity. 4D vs. 3D indices were compared with different machine settings, across the cardiac cycle and in the different placenta regions to assess regional variability.Results3D and 4D indices significantly decreased as wall motion filter (WMF) was increased (P < 0.001). Repeatability decreased as WMF increased (ICC; low1 = 0.80; high1 = 0.60). Indices were significantly lower at the maternal aspect (P = 0.002–0.009) of the placenta and showed less repeatability (ICC; 0.42–0.79) than the fetal aspect (ICC 0.49–0.88). 4D repeatability was good in the central region (ICC 0.80–0.81) but poor in the periphery (ICC 0.45–0.59), while 3D indices were good and comparable between regions (ICC; 0.80 central; 0.81 peripheral).ConclusionsThis study supports the future use of WMF ‘low1’ and PD to generate more reliable 4D indices values. For 3D indices, HD Flow may improve Doppler signal sensitivity. Regarding placental regional variability, the fetal plate and the central region demonstrated more repeatable 4D indices. 4D PD indices have potential to overcome the limitations of VOCAL™ indices and provide an internally standardised measure of localised impedance in vascular beds.
Neutrophil extracellular traps in ischemic stroke thrombi
Authors: Laridan Elodie , Denorme Frederik , Desender Linda , François Olivier , Andersson Tommy , Deckmyn Hans , Vanhoorelbeke Karen , De Meyer Simon F. 
Published: July 2017

ObjectiveNeutrophil extracellular traps (NETs) have been shown to promote thrombus formation. Little is known about the exact composition of thrombi that cause ischemic stroke. In particular, no information is yet available on the presence of NETs in cerebral occlusions. Such information is, however, essential to improve current thrombolytic therapy with tissue plasminogen activator (t‐PA). This study aimed at investigating the presence of neutrophils and more specifically NETs in ischemic stroke thrombi.MethodsSixty‐eight thrombi retrieved from ischemic stroke patients undergoing endovascular treatment were characterized by immunostaining using neutrophil markers (CD66b and neutrophil elastase) and NET markers (citrullinated histone H3 [H3Cit] and extracellular DNA). Neutrophils and NETs were quantified. In addition, extracellular DNA was targeted by performing ex vivo lysis of retrieved thrombi with DNase 1 and t‐PA.ResultsNeutrophils were detected extensively throughout all thrombi. H3Cit, a hallmark of NETs, was observed in almost all thrombi. H3Cit‐positive area varied up to 13.45% of total thrombus area. Colocalization of H3Cit with extracellular DNA released from neutrophils confirmed the specific presence of NETs. H3Cit was more abundant in thrombi of cardioembolic origin compared to other etiologies. Older thrombi contained significantly more neutrophils and H3Cit compared to fresh thrombi. Interestingly, ex vivo lysis of patient thrombi was more successful when adding DNase 1 to standard t‐PA.InterpretationNeutrophils and NETs form important constituents of cerebral thrombi. Targeting of NETs with DNase 1 might have prothrombolytic potential in treatment of acute ischemic stroke. Ann Neurol 2017;82:223–232
Improving collagen extraction through an alternative strategy based on succinic anhydride pretreatment to retain collagen's triple‐helix structure
Authors: Xu Zhou , Guan Xiaoyu , Liu Jie , Fan Haojun , Chen Yi 
Published: July 2017

ABSTRACTThe improvement of the extraction yield of collagen while retaining its triple‐helix structure continues to represent a significant challenge for the high‐value utilization of collagen. In this study, pigskin was pretreated by succinic anhydride via the chemical linking of additional carboxylic groups to epsilon amino groups with a conversion degree of 90.2% to obtain pretreatment acid‐pepsin‐solubilized collagen (PAPC). The pretreatment by succinic anhydride increased the tropocollagen distance from 1.39 to 1.42 nm. This permitted acid and pepsin to more easily enter into the fiber clearance and, thus, improved the collagen extraction yield by 9.6%. Furthermore, X‐ray diffraction, Fourier transform infrared spectroscopy, circular dichroism, ultrasensitive differential scanning calorimetry, and atomic force microscopy analysis demonstrated that the triple‐helix conformation of PAPC was well‐maintained. The equilibrium surface tension and isoelectric point of PAPC were 57.48 mN/m and 4.01, respectively; this suggested that the PAPC had surface activity and better solubility in a neutral pH solution. The novelty of PAPC lay in its facilitating fibroblast proliferation, and no extra cytotoxicity was introduced into the collagen after pretreatment. According to these results, our study revealed that succinic anhydride pretreatment as an alternative strategy retained the triple‐helix structure of collagen and improved its extraction ratio; this might be a feasible, yet promising paradigm for the high‐value utilization of collagen. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45424.
Flexible fluorescent films based on quantum dots (QDs) and natural rubber
Authors: Danna Caroline Silva , Osorio‐Román Igor , Dognani Guilherme , Leopoldo Constantino Carlos Jose , Agarwal Vivechana , Job Aldo Eloizo 
Published: July 2017

ABSTRACTThis article presents the fabrication and characterization of polyisoprene fluorescent films doped with CdTe quantum dots (QDs). The biopolymer (polyisoprene) is extracted from natural rubber latex, generating flexible and transparent films in visible range (transmittance over 90%) ideal as a matrix to support QDs. The water solubility of the biopolymer facilitates its doping with water dispersed QDs at room temperature to obtain the fluorescent films. Thermogravimetric analysis reveals that QDs have no significant effect on the thermal properties of the biopolymer. Photophysical characterization of the solution and solid state (films) of the QDs evidenced that the polymer matrix does not influence its emission properties, the maximum fluorescence peaks have only 2 nm of difference between the solution and solid state (films) samples. Therefore, polyisoprene from natural rubber can be considered as an excellent flexible matrix to fabricate fluorescent films with QDs. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45459.
Global Practical Mittag Leffler Stabilization by Output Feedback for a Class Of Nonlinear Fractional‐Order Systems
Authors: Naifar Omar , Ben Makhlouf Abdellatif , Hammami Mohamed Ali , Chen Liping 
Published: July 2017

AbstractIn this paper, the problem of a global practical Mittag Leffler feedback stabilization for a class of nonlinear fractional order systems by means of observer is described. The linear matrix inequality approach is used to guarantee the practical stability of the proposed feedback fractional order system. An illustrative example is given to show the applicability of the results.
Cardiovascular magnetic resonance imaging for the assessment of ischemic heart disease
Authors: Thompson A. C. M. , Maredia N. 
Published: July 2017

AbstractCardiovascular magnetic resonance imaging (CMR) offers a broader assessment of cardiac structure and function than any other single imaging modality. In patients with known or suspected ischemic heart disease (IHD), a comprehensive CMR protocol provides an assessment of left ventricular function, myocardial perfusion, edema, and viability in a single sitting. There are applications for this technology in both the acute and chronic IHD settings. CMR is also a valuable tool in the assessment of patients presenting with chest pain, raised troponin levels, and unobstructed coronaries.Answer questions and earn CME: https://wileyhealthlearning.com/Activity2/5430068/Activity.aspx
Overview of Admixture Mapping
Authors: Shriner Daniel 
Published: July 2017

AbstractAdmixture mapping is a powerful method of gene mapping for diseases or traits that show differential risk by ancestry. Admixture mapping has been applied most often to Americans who trace ancestry to various combinations of Native Americans, Europeans, and West Africans. Recent developments in admixture mapping include improvements in methods and the reference data needed to make inferences about ancestry, as well as extensions of the mapping approach in the framework of linear mixed models. In this unit, the key concepts of admixture mapping are outlined. Several approaches for inferring local ancestry are described, and strategies for performing admixture mapping depending on the study design are provided. Finally, comparisons and contrasts between linkage analysis, association analysis, and admixture mapping are provided, with an emphasis on integrating admixture mapping and association testing. © 2017 by John Wiley & Sons, Inc.
Brownmillerite‐type Ca2FeCoO5 as a Practicable Oxygen Evolution Reaction Catalyst
Authors: Tsuji Etsushi , Motohashi Teruki , Noda Hiroyuki , Kowalski Damian , Aoki Yoshitaka , Tanida Hajime , Niikura Junji , Koyama Yukinori , Mori Masahiro , Arai Hajime , Ioroi Tsutomu , Fujiwara Naoko , Uchimoto Yoshiharu , Ogumi Zempachi , Habazaki Hiroki 
Published: July 2017

AbstractInvited for this month′s cover is the group of Prof. Dr. Hiroki Habazaki at Hokkaido University with their collaborators from Kanagawa University, Kyoto University, and the National Institute of Advanced Industrial Science and Technology. The image shows the oxygen evolution reaction on brownmillerite‐type Ca2FeCoO5 categorized as an oxygen‐deficiency‐ordered perovskite in a basic solution. The Communication itself is available at 10.1002/cssc.201700499.
Outcomes and healthcare utilization in children and young adults with aplastic anemia: A multiinstitutional analysis
Authors: Gupta Ashish , Fu Pingfu , Hashem Hasan , Vatsayan Anant , Shein Steven , Dalal Jignesh 
Published: July 2017

AbstractBackgroundAplastic anemia is a bone marrow failure syndrome with high mortality affecting children and young adults. Although current treatment guidelines recommend hematopoietic stem cell transplant (HCT) for patients with matched sibling donors, outcomes with alternate donor options have been improving.ProcedureWe analyzed a validated multiinstitutional pediatric cohort using one of the largest pediatric and young adult database, the Pediatric Health Information System, for patients diagnosed with aplastic anemia (AA) from 2006 to 2015. Outcomes with upfront and salvage transplants were analyzed along with healthcare utilization.ResultsAmong 2,169 patients in the study period, almost 20% underwent HCT, while others received immunosuppressive therapy. In a multivariate model, there was no significant difference in mortality with upfront or salvage transplants (odds ratio [OR] 1.24, 95% confidence interval [CI] 0.6–2.58, P = 0.567), while every platelet transfusion was associated with higher mortality (OR 1.37, 95% CI 1.12–1.67, P = 0.002). Healthcare utilization was significantly higher in salvage transplants requiring frequent hospitalization and transfusion requirements. Treatment mortality and graft failure rates were significantly reduced in the salvage transplant group in recent years (2011–2015 as compared to 2006–2010).ConclusionAs outcomes with HCT continue to improve in severe AA, transplant with good alternate donors should be considered upfront in children and young adults.
Pretransplant functional imaging and outcome in pediatric patients with relapsed/refractory Hodgkin lymphoma undergoing autologous transplantation
Authors: Ozuah Nmazuo W. , Dahmoush Hisham M. , Grant Frederick D. , Lehmann Leslie E. , LaCasce Ann S. , Billett Amy L. , Margossian Steven P. 
Published: July 2017

AbstractBackgroundPretransplant functional imaging (FI), particularly a negative positron emission tomography (PET), is a strong predictor of outcome in adults with relapsed or refractory Hodgkin lymphoma (HL), but data in pediatrics are limited.MethodsThe medical records of 49 consecutive pediatric patients, who received autologous transplant at a single institution, were retrospectively analyzed. All patients had either gallium or PET scan before transplant and were conditioned with carmustine, etoposide, cytarabine, and melphalan (BEAM). Deauville scores were retrospectively assigned for patients with PET (score ≥ 4 positive).ResultsOf the 49 patients (median age, 16.2 years), 41 (84%) were pretransplant FI negative and eight (16%) were pretransplant FI positive, after first‐ to fourth‐line salvage therapy, and a median of two salvage cycles. Eighteen patients (37%) received posttransplant radiation. At a median follow up of 46 months, 45 patients (92%) were alive and disease free, and there were three nonrelapse deaths and only one relapse death (Deauville score of 5). The 4‐year progression‐free survival (PFS) for the entire cohort was 92% (95% confidence interval [CI]: 78–97), and PFS based on pretransplant disease status was 95% (95% CI: 82–99%) in the negative FI group versus 75% (95% CI: 31–93) if positive FI (P = 0.057).ConclusionOur analysis revealed outstanding outcomes for children and adolescents with relapsed/refractory HL. There were too few relapses to identify the predictive value of pretransplant metabolic status, but pediatric patients with relapsed/refractory HL and a negative pretransplant FI had excellent survival.
Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature
Authors: Sorge Caryn , Li Rong , Singh Sumit , Reddy Alyssa T. , Solomon David A. , Perry Arie , Friedman Gregory K. 
Published: July 2017

AbstractAnaplastic oligodendroglioma (AO) is rare in children. Treatment typically consists of varying combinations of surgery, chemotherapy, and radiotherapy. We present a pediatric case of frontal lobe AO with periventricular subcallosal extension and local leptomeningeal involvement. The isocitrate dehydrogenase (IDH) wild‐type tumor was MGMT methylated and contained an ATRX mutation, BRAF alteration, and 1p/19q co‐deletion; a combination of alterations mostly encountered in pediatric oligodendrogliomas. The patient underwent a near total resection and had a complete, durable response to temozolomide alone, suggesting that conservative management without radiation may be appropriate in some cases. We review the literature of this uncommon subtype of glioma in children.
Central nervous system relapse of rhabdomyosarcoma
Authors: De Brian , Kinnaman Michael D. , Wexler Leonard H. , Kramer Kim , Wolden Suzanne L. 
Published: July 2017

AbstractPurposeThe optimal management of central nervous system (CNS) relapse of rhabdomyosarcoma (RMS) is unclear. We examined diagnosis, management, and outcomes of patients with RMS developing CNS relapse.MethodsRecords of 23 patients diagnosed with CNS relapse between 1999 and 2016 were reviewed. Median age at presentation of CNS relapse was 15 years (range, 1–34 years). High‐risk features at initial presentation were as follows: 16 alveolar patients, 13 Stage IV, and 13 with primary tumor in parameningeal locations.ResultsCNS relapse occurred at a median 12 months (range, 1–23 months) from diagnosis and most common presenting symptoms were headache (n = 9), nausea/vomiting (n = 8), visual difficulty (n = 5), and none (n = 5). Leptomeningeal metastases were detected in 21 patients while only 2 developed parenchymal metastases without leptomeningeal involvement. Fifteen patients received CNS‐directed radiation therapy (RT), including craniospinal irradiation to a median 36 Gy (range, 18–36 Gy) and/or whole brain radiotherapy to a median 30 Gy (range, 6–41.4 Gy). Three patients received concurrent chemotherapy. Follow‐up magnetic resonance imaging was conducted in 13 patients after RT initiation with 8 demonstrating improvement, 2 with stable disease, and 3 with progression. Twelve patients were tested for reactivity to I‐131‐labeled monoclonal antibody 8H9, and three tested positive and received at least one intra‐Ommaya dose; all three lived >12 months post‐CNS relapse. Twenty‐one patients died of CNS disease and two of metastatic disease at other sites. Median survival post‐CNS relapse was 5 months (range, 0.1–49 months).ConclusionsThe prognosis for patients with RMS developing CNS relapse remains poor. Treatment including CNS‐directed RT should be considered and investigation into preventative therapies is warranted.
Screening of antigenic vesicular fluid proteins of Echinococcus multilocularis as potential viability biomarkers to monitor drug response in alveolar echinococcosis patients
Authors: Valot Benoît , Rognon Bénédicte , Prenel Anais , Baraquin Alice , Knapp Jenny , Anelli Mathilde , Richou Carine , Bresson‐Hadni Solange , Grenouillet Frederic , Wang Junhua , Vuitton Dominique Angèle , Gottstein Bruno , Millon Laurence 
Published: July 2017

PurposeThe only drugs available to treat alveolar echinococcosis (AE) are mostly parasitostatic and in many cases prescribed for life. Decision criteria for discontinuation rely on the absence of parasitic viability. The aim of the present study is to search for candidate proteins that may exhibit good potential as biomarkers for viability.Experimental designSixteen serum samples (five healthy controls, 11 patients with AE), are used. AE‐patients are classified into three groups “Cured” (n = 2), “ABZ‐responders” (n = 4) and “ABZ‐nonresponders” (n = 5). Immunoreactive proteins from vesicular fluid (VF) are identified and quantified by LC‐MS/MS analysis after immunoprecipitation (IP) using all 16 serum samples.ResultsShotgun analysis of VF lead to the identification of 107 E. multilocularis proteins. Comparative proteomics reveal nine proteins more abundant in IP eluates from ABZ‐nonresponder patients (cathepsin b, prosaposin a preprotein, actin modulator protein, fucosidase alpha L1 tissue, gluthatione‐S‐tranferase, beta galactosidase, elongation factor 2, H17g protein tegumental antigen, and NiemannPick C2 protein).Conclusions and clinical relevanceDetection of antibodies against these proteins by ELISA could be helpful to monitor the course of alveolar echinococcosis under albendazole (ABZ) treatment.
Synthesis of Hybrid to Inorganic Quasi 2D‐Layered Perovskite Nanoparticles
Authors: Aamir Muhammad , Khan Malik Dilshad , Sher Muhammad , Malik Mohammad Azad , Akhtar Javeed , Revaprasadu Neerish 
Published: July 2017

AbstractMetal halide perovskites have emerged as a potential candidate for photovoltaic and light emitting applications. Tuning the optical properties by tailoring the perovskite nanostructures could enhance the efficiency of these devices. Herein, we report the synthesis of hybrid to inorganic quasi‐2D perovskites, by using different ratios of PhNH3Br and CsI, to prepare (Cs)x(PhNH3)2‐2xPbBr4‐xIx nanomaterials. The as‐prepared nanostructures were characterized by powder X‐ray diffraction (p‐XRD), Fourier transform infrared spectroscopy (FTIR) and ultraviolet‐visible spectroscopy (UV/Vis). Transmission electron microscopy (TEM) showed that the shape of the as‐prepared nanostructures can be tuned from rectangle/rods to sheet like structures. It was observed that the ratio of the organic cation (anilinium ion) plays a crucial role in the development of the perovskite crystallites size and shape. This is the first such study on the conversion of hybrid 2D perovskite to inorganic quasi‐2D perovskite by using inorganic cation (Cs+) and could be a potential material for optoelectronic applications.
Patients come from populations and populations contain patients. A two‐stage scientific and ethics review: The next adaptation for single institutional review boards
Authors: Knopman David , Alford Eli , Tate Kaitlin , Long Mark , Khachaturian Ara S. 
Published: July 2017

AbstractIntroductionFor nearly 50 years, institutional review boards (IRB) and independent ethics committees have featured local oversight as a core function of research ethics reviews. However growing complexity in Alzheimer's clinical research suggests current approaches to research volunteer safety is hampering development of new therapeutics. As a partial response to this challenge, the NIH has mandated that all NIH‐funded multi‐site studies will use a single Institutional Review Board. The perspective describes a joint program to provide a single IRB of record (sIRB) for phases of multi‐site studies.MethodsThe approach follows two steps. One, an expert Scientific Review Committee (SRC) of senior researchers in the field will conduct the review principally of scientific merit, significance, feasibility, and the likelihood of meaningful results. The second step will be the IRB's regulatory and ethics review. The IRB will apply appropriate regulatory criteria for approval including minimization of risks to subjects and risks reasonable in relation to anticipated benefits, equitable subject selection, informed consent, protections for vulnerable populations, and application of local context considerations, among others.ResultsThere is a steady demand for scientific, ethical and regulatory review of planned Alzheimer's studies. As of January 15, 2017, there are nearly 400 open studies, Phase II and III, industry and NIH sponsored trials on disease indications affecting memory, movement and mood in the US.ConclusionsThe effort will initially accept protocols for studies of Alzheimer's disease, dementia, and related disorders effecting memory, movement and mood. Future aims will be to provide scientific review and, where applicable, regulatory and ethical review in an international context outside North America with sites possibly in Asia, Europe and Australia.