bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐weighing behavior in individuals with eating disorders
Authors: Pacanowski Carly R. , Pisetsky Emily M. , Berg Kelly C. , Crosby Ross D. , Crow Scott J. , Linde Jennifer A. , Mitchell James E. , Engel Scott G. , Klein Marjorie H. , Smith Tracey L. , Le Grange Daniel , Wonderlich Stephen A. , Peterson Carol B. 
Published: May 2016

ABSTRACTObjectiveTo describe the frequency of self‐weighing and reactions to prescribed weekly weighing among individuals with eating disorder (ED) diagnoses, and to compare individuals weighing more or less frequently on mass index (BMI) and the Eating Disorder Examination (EDE) subscales.MethodBaseline EDE and demographics from five studies (N = 758).ResultsSelf‐weighing was most frequent among individuals with anorexia nervosa (AN), followed by those with bulimia nervosa (BN) and binge eating disorder (BED). On average, participants reacted moderately negative to prescribed weekly weighing. No relationship between weighing frequency and BMI was evident in any sample. There was indication of greater pathology (i.e., restraint, shape concern, weight concern, global) in AN with more frequent weighing. In BN, mixed evidence emerged to support a relationship between more frequent weighing and higher shape concern, weight concern, and global score. In BED, higher restraint was found in those who weighed versus those who did not.DiscussionWeighing frequency in each eating disorder (ED) sample was to some extent associated with greater ED severity, but not BMI. Future research should examine relationships between self‐weighing, reactions to changing weighing frequency, and ED symptomatology in both ED and non‐ED groups to understand the impact of self‐weighing in heterogeneous populations. © 2016 Wiley Periodicals, Inc. (Int J Eat Disord 2016; 49:817–821)
The body project 4 all: A pilot randomized controlled trial of a mixed‐gender dissonance‐based body image program
Authors: Kilpela Lisa Smith , Blomquist Kerstin , Verzijl Christina , Wilfred Salomé , Beyl Robbie , Becker Carolyn Black 
Published: May 2016

ABSTRACTObjectiveThe Body Project is a cognitive dissonance‐based body image improvement program with ample research support among female samples. More recently, researchers have highlighted the extent of male body dissatisfaction and disordered eating behaviors; however, boys/men have not been included in the majority of body image improvement programs. This study aims to explore the efficacy of a mixed‐gender Body Project compared with the historically female‐only body image intervention program.MethodParticipants included male and female college students (N = 185) across two sites. We randomly assigned women to a mixed‐gender modification of the two‐session, peer‐led Body Project (MG), the two‐session, peer‐led, female‐only (FO) Body Project, or a waitlist control (WL), and men to either MG or WL. Participants completed self‐report measures assessing negative affect, appearance‐ideal internalization, body satisfaction, and eating disorder pathology at baseline, post‐test, and at 2‐ and 6‐month follow‐up.ResultsLinear mixed effects modeling to estimate the change from baseline over time for each dependent variable across conditions were used. For women, results were mixed regarding post‐intervention improvement compared with WL, and were largely non‐significant compared with WL at 6‐month follow‐up. Alternatively, results indicated that men in MG consistently improved compared with WL through 6‐month follow‐up on all measures except negative affect and appearance‐ideal internalization.DiscussionResults differed markedly between female and male samples, and were more promising for men than for women. Various explanations are provided, and further research is warranted prior to drawing firm conclusions regarding mixed‐gender programming of the Body Project. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:591–602)
Curvilinear smoothed particle hydrodynamics
Authors: Tavakkol Sasan , Zarrati Amir Reza , Khanpour Mahdiyar 
Published: May 2016

SummaryWe suggest a new set of equations to employ smoothed particle hydrodynamics (SPH) in a curvilinear space, and we refer to it as curvSPH. In classical SPH, the horizontal and vertical resolution of discretization is supposed to be equal for fluid particles. However, curvSPH makes the horizontal and vertical resolutions independent from each other. This is performed by transformation of physical space into an appropriate computational space with a different scale in horizontal and vertical directions. Solving a problem using SPH in a curvilinear space also provides capability to model curved boundaries as straight lines. In classical SPH, special care is needed to reach a uniform mass distribution along curved boundaries; however, producing uniform mass distribution along a line using curvSPH is straight forward. Different simulations, including simulation of a flip bucket are performed to demonstrate the applicability of the proposed method. Good agreement of results with experimental data and classical SPH confirms the capabilities of curvSPH. Copyright © 2016 John Wiley & Sons, Ltd.
Average and Marginal Returns to Upper Secondary Schooling in Indonesia
Authors: Carneiro Pedro , Lokshin Michael , Umapathi Nithin 
Published: May 2016

SummaryThis paper estimates average and marginal returns to schooling in Indonesia using a semiparametric selection model. Identification of the model is given by geographic variation in access to upper secondary schools. We find that the return to upper secondary schooling varies widely across individuals: it can be as high as 50% per year of schooling for those very likely to enroll in upper secondary schooling, or as low as −10% for those very unlikely to do so. Average returns for the student at the margin are substantial, but they are also well below those for the average student attending upper secondary schooling. Copyright © 2016 John Wiley & Sons, Ltd.
Acetyl L‐carnitine targets adenosine triphosphate synthase in protecting zebrafish embryos from toxicities induced by verapamil and ketamine: An in vivo assessment
Authors: Guo Xiaoqing , Dumas Melanie , Robinson Bonnie L. , Ali Syed F. , Paule Merle G. , Gu Qiang , Kanungo Jyotshna 
Published: May 2016

AbstractVerapamil is a Ca2+ channel blocker and is highly prescribed as an anti‐anginal, antiarrhythmic and antihypertensive drug. Ketamine, an antagonist of the Ca2+‐permeable N‐methyl‐d‐aspartate‐type glutamate receptors, is a pediatric anesthetic. Previously we have shown that acetyl l‐carnitine (ALCAR) reverses ketamine‐induced attenuation of heart rate and neurotoxicity in zebrafish embryos. Here, we used 48 h post‐fertilization zebrafish embryos that were exposed to relevant drugs for 2 or 4 h. Heart beat and overall development were monitored in vivo. In 48 h post‐fertilization embryos, 2 mm ketamine reduced heart rate in a 2 or 4 h exposure and 0.5 mm ALCAR neutralized this effect. ALCAR could reverse ketamine's effect, possibly through a compensatory mechanism involving extracellular Ca2+ entry through L‐type Ca2+ channels that ALCAR is known to activate. Hence, we used verapamil to block the L‐type Ca2+ channels. Verapamil was more potent in attenuating heart rate and inducing morphological defects in the embryos compared to ketamine at specific times of exposure. ALCAR reversed cardiotoxicity and developmental toxicity in the embryos exposed to verapamil or verapamil plus ketamine, even in the presence of 3,4,5‐trimethoxybenzoic acid 8‐(diethylamino)octyl ester, an inhibitor of intracellular Ca2+ release suggesting that ALCAR acts via effectors downstream of Ca2+. In fact, ALCAR's protective effect was blunted by oligomycin A, an inhibitor of adenosine triphosphate synthase that acts downstream of Ca2+ during adenosine triphosphate generation. We have identified, for the first time, using in vivo studies, a downstream effector of ALCAR that is critical in abrogating ketamine‐ and verapamil‐induced developmental toxicities. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
Sex- and Site-Specific Normative Data Curves for HR-pQCT
Authors: Burt Lauren A , Liang Zhiying , Sajobi Tolulope T , Hanley David A , Boyd Steven K 
Published: May 2016

ABSTRACT

The purpose of this study was to develop age-, site-, and sex-specific centile curves for common high-resolution peripheral quantitative computed tomography (HR-pQCT) and finite-element (FE) parameters for males and females older than 16 years. Participants (n = 866) from the Calgary cohort of the Canadian Multicentre Osteoporosis Study (CaMos) between the ages of 16 and 98 years were included in this study. Participants’ nondominant radius and left tibia were scanned using HR-pQCT. Standard and automated segmentation methods were performed and FE analysis estimated apparent bone strength. Centile curves were generated for males and females at the tibia and radius using the generalized additive models for location, scale, and shape (GAMLSS) package in R. After GAMLSS analysis, age-, sex-, and site-specific centiles (10th, 25th, 50th, 75th, 90th) for total bone mineral density and trabecular number as well as failure load have been calculated. Clinicians and researchers can use these reference curves as a tool to assess bone health and changes in bone quality. © 2016 American Society for Bone and Mineral Research.
Cycloheximide Inhibits Actin Cytoskeletal Dynamics by Suppressing Signaling via RhoA
Authors: Darvishi Emad , Woldemichael Girma M. 
Published: May 2016

ABSTRACTGenome‐wide screening of the yeast Saccharomyces cerevisiae knockout collection was used to characterize chemical‐genetic interactions of cycloheximide (CHX). The results showed that while the act1Δ mutant was the only deletion mutant in the heterozygous essential gene deletion collection that showed hypersensitivity to sub‐inhibitory concentrations of CHX, deletion of nonessential genes that work in concert with either cytoplasmic or nuclear actin in the homozygous deletion collection also highly sensitized yeast to CHX. Fluorescence microscopy analysis revealed that CHX disrupts filamentous actin structures and fluid phase endocytosis in the yeast cell. It also showed that CHX disrupts transforming growth factor‐β1 (TGF‐β1)‐induced actin reorganization and polygonal architecture of microfilaments in mammalian cells. This inhibitory effect is mediated, at least in part, through the actin dynamics signaling pathway via suppression of activation of the small GTPase RhoA. J. Cell. Biochem. 117: 2886–2898, 2016. © 2016 Wiley Periodicals, Inc.
Fully Automated RNAscope In Situ Hybridization Assays for Formalin‐Fixed Paraffin‐Embedded Cells and Tissues
Authors: Anderson Courtney M. , Zhang Bingqing , Miller Melanie , Butko Emerald , Wu Xingyong , Laver Thomas , Kernag Casey , Kim Jeffrey , Luo Yuling , Lamparski Henry , Park Emily , Su Nan , Ma Xiao‐Jun 
Published: May 2016

ABSTRACTBiomarkers such as DNA, RNA, and protein are powerful tools in clinical diagnostics and therapeutic development for many diseases. Identifying RNA expression at the single cell level within the morphological context by RNA in situ hybridization provides a great deal of information on gene expression changes over conventional techniques that analyze bulk tissue, yet widespread use of this technique in the clinical setting has been hampered by the dearth of automated RNA ISH assays. Here we present an automated version of the RNA ISH technology RNAscope that is adaptable to multiple automation platforms. The automated RNAscope assay yields a high signal‐to‐noise ratio with little to no background staining and results comparable to the manual assay. In addition, the automated duplex RNAscope assay was able to detect two biomarkers simultaneously. Lastly, assay consistency and reproducibility were confirmed by quantification of TATA‐box binding protein (TBP) mRNA signals across multiple lots and multiple experiments. Taken together, the data presented in this study demonstrate that the automated RNAscope technology is a high performance RNA ISH assay with broad applicability in biomarker research and diagnostic assay development. J. Cell. Biochem. 117: 2201–2208, 2016. © 2016 The Authors. Journal of Cellular Biochemistry Published by Wiley Periodicals, Inc.
Features of successful academic hospitalist programs: Insights from the SCHOLAR (SuCcessful HOspitaLists in academics and research) project
Authors: Seymann Gregory B. , Southern William , Burger Alfred , Brotman Daniel J. , Chakraborti Chayan , Harrison Rebecca , Parekh Vikas , Sharpe Bradley A. , Pile James , Hunt Daniel , Leykum Luci K. 
Published: May 2016

BACKGROUNDAs clinical demands increase, understanding the features that allow academic hospital medicine programs (AHPs) to thrive has become increasingly important.OBJECTIVETo develop and validate a quantifiable definition of academic success for AHPs.METHODSA working group of academic hospitalists was formed. The group identified grant funding, academic promotion, and scholarship as key domains reflective of success, and specific metrics and approaches to assess these domains were developed. Self‐reported data on funding and promotion were available from a preexisting survey of AHP leaders, including total funding/group, funding/full‐time equivalent (FTE), and number of faculty at each academic rank. Scholarship was defined in terms of research abstracts presented over a 2‐year period. Lists of top performers in each of the 3 domains were constructed. Programs appearing on at least 1 list (the SCHOLAR cohort [SuCcessful HOspitaLists in Academics and Research]) were examined. We compared grant funding and proportion of promoted faculty within the SCHOLAR cohort to a sample of other AHPs identified in the preexisting survey.RESULTSSeventeen SCHOLAR programs were identified, with a mean age of 13.2 years (range, 6–18 years) and mean size of 36 faculty (range, 18–95). The mean total grant funding/program was $4 million (range, $0–$15 million), with mean funding/FTE of $364,000 (range, $0–$1.4 million); both were significantly higher than the comparison sample. The majority of SCHOLAR faculty (82%) were junior, a lower percentage than the comparison sample. The mean number of research abstracts presented over 2 years was 10.8 (range, 9–23).DISCUSSIONOur approach effectively identified a subset of successful AHPs. Despite the relative maturity and large size of the programs in the SCHOLAR cohort, they were comprised of relatively few senior faculty members and varied widely in the quantity of funded research and scholarship. Journal of Hospital Medicine 2016;11:708–713. © 2016 Society of Hospital Medicine
Osteological Observations on the Alytid Anura Latonia nigriventer with Comments on Functional Morphology, Biogeography, and Evolutionary History
Authors: Biton Rebecca , Boistel Renaud , Rabinovich Rivka , Gafny Sarig , Brumfeld Vlad , Bailon Salvador 
Published: May 2016

ABSTRACTThe Hula Painted Frog (Latonia nigriventer) is a rare frog species endemic to the Hula Valley, Israel. The species is the sole relict of a clade that was widespread mainly in Europe from the Oligocene until the beginning of the Pleistocene. The osteological characteristics of L. nigriventer are described based on X‐ray microtomography scans of extant specimens and Pleistocene bones from the Hula Valley, to elucidate the evolutionary history of Alytidae and more specifically of Latonia. Based on the osteological description of L. nigriventer, we now better understand the differences, between Latonia and its sister taxon Discoglossus. They differ mainly in their cranial structure with the reinforced skull of Latonia having powerful jaws. Latonia nigriventer can achieve great force while closing its jaws, due to increased adductor muscle insertion surfaces as expressed by the presence of an additional paracoronoid process and an enlarged upper margin of the postero‐lateral wall of the lower jaw. In addition, a wider pterygoid fossa and higher canthus postero‐lateralis of the frontoparietal, compared to that of Discoglossus, also suggest the presence of well‐developed adductor muscles. Furthermore, L. nigriventer have particularly strong skulls as expressed by: long articulations between different skull elements, interdigitation in the contact area between the nasals and between nasals and the frontoparietals, and fused frontoparietals. Both males and females L. nigriventer have very robust forelimbs, as indicated by well‐developed medial crests of the humerus. Based on limited eastern Mediterranean paleontological data, we can only suspect that the dispersal of Latonia into the Levant from Asia Minor occurred at some point during the Miocene or later. The first appearance of L. nigriventer in the Hula Valley, its current habitat, dates to approximately 780 thousand years ago at the archaeological site of Gesher Benot Ya‘aqov. J. Morphol. 277:1131–1145, 2016. © 2016 Wiley Periodicals, Inc.
Isolated limb perfusion in Merkel cell carcinoma offers high rate of complete response and durable local–regional control: Systematic review and institutional experience
Authors: Thiels Cornelius A. , Gonzalez Alexandra B. , Gray Richard J. , Jakub James W. 
Published: May 2016

IntroductionHyperthermic isolated limb perfusion (HILP) has an established role in the management of melanoma, but its role for Merkel cell carcinoma (MCC) is less well defined.MethodsRetrospective review of our institutional experience with HILP for MCC was conducted (2009–2015). Literature search was performed through 04/2015 and 10 studies met inclusion criteria.ResultsFour patients underwent HILP for MCC at our institution. There were no major complications and complete response was achieved in all patients. Early metastatic recurrence developed in two patients. The remaining two had no evidence of disease at last follow‐up (36 months) or death (39 months). Systematic review identified an additional 12 pts that underwent HILP for MCC, for a total of 16 cases. Median age was 73 [IQR 69–78] years and 56% were men. Of the patients with reported follow‐up, 12 (86%) had complete response, 1 had stable disease, and 1 partial response. Four patients developed local–regional recurrence and six distant metastases, all within 6 months. Overall median follow‐up time was 15 [7–36] months.ConclusionAmong a highly selective group of patients, regional perfusion for MCC is safe and has a high complete response rate. HILP is an acceptable therapeutic modality for obtaining durable loco‐regional control but early distant metastatic disease remains a significant cause of mortality. J. Surg. Oncol. 2016;114:187–192. © 2016 Wiley Periodicals, Inc.
Adjusting Local Molecular Environment for Giant Ambient Thermal Contraction
Authors: Shen Xingyuan , Connolly Timothy , Huang Yuhui , Colvin Michael , Wang Changchun , Lu Jennifer 
Published: May 2016

A low‐energy triggered switch that can generate mechanoresponse has great technological potential. A submolecular moiety, S‐dibenzocyclooctadiene (DBCOD) that is composed of a flexible eight‐membered ring connecting to a phenyl ring at each end, undergoes a conformational change from twist‐boat to chair under a low‐energy stimulus such as near infrared irradiation, resulting in thermal contraction of DBCOD‐based polymer. Experimental evidence corroborated by theoretical calculations indicates that introducing molecular asymmetry can reduce crystallinity significantly and consequently facilitate the kinetics of the conformational change. It has been demonstrated that the negative thermal expansion (NTE) coefficient of a DBCOD‐based polymer system can be adjusted in a range from −1140 to −2350 ppm K−1. −2350 ppm K−1 is ≈10 times better than the value reported by the second best NTE system.
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Online traffic prediction in the cloud
Authors: Dalmazo Bruno L. , Vilela João P. , Curado Marilia 
Published: May 2016

SummaryNetwork traffic prediction is a fundamental tool to harness several management tasks, such as monitoring and managing network traffic. Online traffic prediction is usually performed based on large sets of historical data used in training algorithms, for example, to determine the size of static windows to bound the amount of traffic under consideration. However, using large sets of historical data may not be suitable in highly volatile environments, such as cloud computing, where the coupling between time series observations decreases rapidly with time. To fill this gap, this work presents a dynamic window size algorithm for traffic prediction that contains a methodology to optimize a threshold parameter alpha that affects both the prediction and computational cost of our scheme. The alpha parameter defines the minimum data traffic variability needed to justify dynamic window size changes. Thus, with the optimization of this parameter, the number of operations of the dynamic window size algorithm decreases significantly. We evaluate the alpha estimation methodology against several prediction models by assessing the normalized mean square error and mean absolute percent error of predicted values over observed values from two real cloud computing datasets, collected by monitoring the utilization of Dropbox, and a data center dataset including traffic from several common cloud computing services. Copyright © 2016 John Wiley & Sons, Ltd.
High‐efficiency GaInP/GaAs/GaInNAs solar cells grown by combined MBE‐MOCVD technique
Authors: Tukiainen Antti , Aho Arto , Gori Gabriele , Polojärvi Ville , Casale Mariacristina , Greco Erminio , Isoaho Riku , Aho Timo , Raappana Marianna , Campesato Roberta , Guina Mircea 
Published: May 2016

AbstractTriple‐junction GaInP/GaAs/GaInNAs solar cells with conversion efficiency of ~29% at AM0 are demonstrated using a combination of molecular beam epitaxy (MBE) and metal‐organic chemical vapor deposition (MOCVD) processes. The bottom junction made of GaInNAs was first grown on a GaAs substrate by MBE and then transferred to an MOCVD system for subsequent overgrowth of the two top junctions. The process produced repeatable cell characteristics and uniform efficiency pattern over 4‐inch wafers. Combining the advantages offered by MBE and MOCVD opens a new perspective for fabrication of high‐efficiency tandem solar cells with three or more junctions. Copyright © 2016 John Wiley & Sons, Ltd.
A reference library of peripheral blood mononuclear cells for SWATH‐MS analysis
Authors: Silva Carolina , Santa Cátia , Anjo Sandra Isabel , Manadas Bruno 
Published: May 2016

PurposePeripheral blood mononuclear cells (PBMCs) play quite diverse and important roles in monitoring immune homeostasis. Thus, this subset of blood cells may provide access to potential physiological relevant biomolecules, namely proteins. For this reason, PBMCs represent a promising alternative biological sample in scientific research, particularly as a source of potential biomarkers. Prior proteomic studies of PBMCs from healthy individuals focused only on a qualitative analysis, lacking the quantitative analysis information crucial for biomarker discovery, since most of the biological alterations result in slight changes in protein levels, not affecting the overall proteome composition. Therefore, this study aimed to provide a comprehensive PBMCs proteome library to be use in protein quantification by SWATH‐MS.Experimental designA SWATH‐MS library was generated by a comprehensive 2D‐LC‐MS/MC analysis of a pooled sample of PBMCs from 6 different donors. GeLC‐SWATH‐MS analysis of the 6 donors was further used to test the generated library.ResultsThe generated library comprises 1102 proteins involved in diverse human diseases and in immune system‐related pathways. When tested in biological samples this library allowed the quantification of 920 different proteins, and around 700 per individual.Conclusions and clinical relevanceThe provided PBMCs proteome library will be useful in further studies that aim to reproducibly quantify a large number of PBMCs' proteins without the need to perform protein identification. Furthermore, this robust microLC‐SWATH‐MS analysis is suitable with clinical practice