bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Rest-Break Intention on Rest-Break Frequency and Work-Related Fatigue
Authors: Blasche Gerhard , Pasalic Sanja , Bauböck Verena-Maria , Haluza Daniela , Schoberberger Rudolf 
Published: October 2016

Objectives: The present paper presents findings from two studies addressing the effects of the employee’s intention to have rest breaks on rest-break frequency and the change of well-being during a workday. Background: Rest breaks are effective in avoiding an accumulation of fatigue during work. However, little is known about individual differences in rest-break behavior. Method: In Study 1, the association between rest-break intention and the daily number of rest breaks recorded over 4 consecutive workdays was determined by generalized linear model in a sample of employees ( n = 111, 59% females). In Study 2, professional geriatric nurses ( n = 95 females) who worked over two consecutive 12-hour day shifts recorded well-being (fatigue, distress, effort motivation) at the beginning and the end of their shifts. The effect of rest-break intention on the change of well-being was determined by multilevel modeling. Results: Rest-break intention was positively associated with the frequency of rest breaks (Study 1) and reduced the increase of fatigue and distress over the workday (Study 2). Conclusion: The results indicate that individual differences account for the number of breaks an employee takes and, as a consequence, for variations in the work-related fatigue and distress. Application: Strengthening rest-break intentions may help to increase rest-break behavior to avoid the buildup of fatigue and distress over a workday.
Assessment of the wish to hasten death in patients with advanced disease: A systematic review of measurement instruments
Authors: Bellido-Pérez Mercedes , Monforte-Royo Cristina , Tomás-Sábado Joaquín , Porta-Sales Josep , Balaguer Albert 
Published: October 2016

Background: Patients with advanced conditions may present a wish to hasten death. Assessing this wish is complex due to the nature of the phenomenon and the difficulty of conceptualising it. Aim: To identify and analyse existing instruments for assessing the wish to hasten death and to rate their reported psychometric properties. Design: Systematic review based on PRISMA guidelines. The COnsensus-based Standards for the selection of health Measurement INstruments checklist was used to evaluate the methodological quality of validation studies and the measurement properties of the instrument described. Data sources: The CINAHL, PsycINFO, Pubmed and Web of Science databases were searched from inception to November 2015. Results: A total of 50 articles involving assessment of the wish to hasten death were included. Eight concerned instrument validation and were evaluated using COnsensus-based Standards for the selection of health Measurement INstruments criteria. They reported data for between two and seven measurement properties, with ratings between fair and excellent. Of the seven instruments identified, the Desire for Death Rating Scale or the Schedule of Attitudes toward Hastened Death feature in 48 of the 50 articles. The Schedule of Attitudes toward Hastened Death is the most widely used and is the instrument whose psychometric properties have been most often analysed. Versions of the Schedule of Attitudes toward Hastened Death are available in five languages other than the original English. Conclusion: This systematic review has analysed existing instruments for assessing the wish to hasten death. It has also explored the methodological quality of studies that have examined the measurement properties of these instruments and offers ratings of the reported properties. These results will be useful to clinicians and researchers with an interest in a phenomenon of considerable relevance to advanced patients.
Evaluation of the carotid artery stenosis based on minimization of mechanical energy loss of the blood flow
Authors: Sia Sheau Fung , Zhao Xihai , Li Rui , Zhang Yu , Chong Winston , He Le , Chen Yu 
Published: October 2016

Background: Internal carotid artery stenosis requires an accurate risk assessment for the prevention of stroke. Although the internal carotid artery area stenosis ratio at the common carotid artery bifurcation can be used as one of the diagnostic methods of internal carotid artery stenosis, the accuracy of results would still depend on the measurement techniques. The purpose of this study is to propose a novel method to estimate the effect of internal carotid artery stenosis on the blood flow based on the concept of minimization of energy loss. Methods: Eight internal carotid arteries from different medical centers were diagnosed as stenosed internal carotid arteries, as plaques were found at different locations on the vessel. A computational fluid dynamics solver was developed based on an open-source code (OpenFOAM) to test the flow ratio and energy loss of those stenosed internal carotid arteries. For comparison, a healthy internal carotid artery and an idealized internal carotid artery model have also been tested and compared with stenosed internal carotid artery in terms of flow ratio and energy loss. Results: We found that at a given common carotid artery bifurcation, there must be a certain flow distribution in the internal carotid artery and external carotid artery, for which the total energy loss at the bifurcation is at a minimum; for a given common carotid artery flow rate, an irregular shaped plaque at the bifurcation constantly resulted in a large value of minimization of energy loss. Thus, minimization of energy loss can be used as an indicator for the estimation of internal carotid artery stenosis.
Exploring early language detection in balanced bilingual children: The impact of language-specificity on cross-linguistic nonword recognition
Authors: Schröter Pauline , Schroeder Sascha 
Published: October 2016

Aims and objectives: Recent findings on the mechanisms of lexical access suggest that bilinguals are sensitive to the orthographic structure of their languages. Several studies have demonstrated that if presented with language-specific sub-lexical information, bilingual adults use this information to speed up word recognition, which provides evidence for language-selective lexical access. In the present study, we investigated the presence of such an early language detection mechanism in children. Methodology: Forty-six balanced bilingual third-graders performed two seemingly monolingual lexical decision tasks, one in English and one in German, including nonwords with different degrees of word-likeness in each language. Data and analysis: Accuracy scores and reaction times were analyzed for nonwords using mixed-effects models with the statistical software R. Findings: Results show no impact of language-specific sub-lexical information on children’s performance in either task. We argue that bilingual lexical access is initially language-nonselective, and that sensitivity to language-specific orthographic structures first emerges over time. In contrast to bilingual adults, language detection in bilingual children is exclusively based on lexical information. Originality: The present study provides first data on the detection mechanism for language membership at the early stages of bilingual reading development. We are the first to demonstrate an important difference in the architecture of the bilingual lexicon between children and adults. Implications: Findings contribute to knowledge on the development of lexical access in bilinguals and pose limitations to the generalizability of the Bilingual Interactive Activation Plus (BIA+) extended model.
Biological Knee Reconstruction With Concomitant Autologous Chondrocyte Implantation and Meniscal Allograft Transplantation
Authors: Ogura Takahiro , Bryant Tim , Minas Tom 
Published: October 2016

Background: Treating articular cartilage defects and meniscal deficiency is challenging. Although some short- to mid-term follow-up studies report good clinical outcomes after concurrent autologous chondrocyte implantation (ACI) and meniscal allograft transplantation (MAT), longer follow-up is needed. Purpose: To evaluate mid- to long-term outcomes after combined ACI with MAT. Study Design: Case series; Level of evidence, 4. Methods: We performed a retrospective review of prospectively gathered data from patients who had undergone ACI with MAT between 1999 and 2013. A single surgeon treated 18 patients for symptomatic full-thickness chondral defects with meniscal deficiency. One patient was lost to follow-up. Thus, 17 patients (18 knees; mean age, 31.7 years) were evaluated over a mean 7.9-year follow-up (range, 2-16 years). A mean 1.8 lesions per knee were treated over a total surface area of 7.6 cm2 (range, 2.3-21 cm2) per knee. Seventeen lateral and 1 medial MATs were performed. Survival was analyzed using the Kaplan-Meier method. The modified Cincinnati Knee Rating Scale, Western Ontario and McMaster Universities Osteoarthritis Index, visual analog scale, and Short Form–36 were used to evaluate clinical outcomes. Patients also self-reported knee function and satisfaction. Standard radiographs were scored for Kellgren-Lawrence (K-L) grade. Results: Both 5- and 10-year survival rates were 75%. Outcomes for 6 knees were considered failures. Of the 6 failures, 4 knees were converted to arthroplasty and the other 2 knees underwent biological revision surgery. Of the 12 successfully operated knees, all clinical measures significantly improved postoperatively. Ten patients representing 11 of the 12 knees rated outcomes for their knees as good or excellent, and 1 rated their outcome as fair. Eight patients representing 9 of the 12 knees were satisfied with the procedure. There was no significant osteoarthritis progression based on K-L grading from preoperatively to a mean 5.9 years after surgery. Seven of the 12 knees (58%) required subsequent surgical procedures (5 arthroscopic alone, 2 both arthroscopic and open). Conclusion: Combined ACI with MAT provided significant improvement in 65% of the operated knees over a mid- to long-term follow-up. This procedure can allow patients to retain their biological knees, delay or prevent rapid degeneration to osteoarthritis, and could be recognized as a bridge procedure before artificial knee replacement. However, careful discussion between the patient and surgeon is necessary before surgery to ensure realistic expectations.
Halloysite nanotubes as a new drug-delivery system: a review
Authors: Hanif Muhammad , Jabbar Fazila , Sharif Sana , Abbas Ghulam , Farooq Athar , Aziz Mubashar 
Published: October 2016

AbstractNew drug-delivery systems have remained a challenge for pharmaceutical scientists due to the use of expensive polymers and the low loading capacity of prepared nanoparticles. There is pressure to develop formulations that contain not only cheaper materials but also have controlled-release properties. Halloysite nanotubes (HNTs) are a naturally occurring clay mineral similar to kaolin, possessing a special particle shape in the form of an ultramicroscopic multilayered hollow cylinder. Its uses encompass a wide range in anticancer therapy, sustained- and controlled-release drug-delivery systems, cosmetics, delivery of proteins, vaccines and genes. These advantages are due to its biocompatibility, significant mechanical strength and natural availability. The surfaces of the tubules can be modified by coating different polymers for application in the drug-delivery system. This review is focused on the various aspects of HNTs such as structure, properties, loading methods, applications and characterizations.
Halloysite behaving badly: geomechanics and slope behaviour of halloysite-rich soils
Authors: Moon Vicki 
Published: October 2016

AbstractHalloysite-rich soils derived fromin situweathering of volcanic materials support steep stable slopes, but commonly fail under triggers of earthquakes or rainfall. Resulting landslides are slideflow processes, ranging from small translational slides to larger rotational failures with scarps characteristic of sensitive soils. Remoulding of failed materials results in high-mobility flows with apparent friction angles of 10–16°. The materials characteristically have high peak-friction angles (∼25– 37°), low cohesion (∼12–60 kN m−2) and plasticity ( plasticity index ∼10–48%), and low dry bulk density (∼480–1,080 kg m−3) with small pores due to the small size of the halloysite minerals. They remain saturated under most field conditions, with liquidity indexes frequently >1. Remoulded materials have limited cohesion (<5 kN m−2) and variable residual friction angles (15°–35°). Halloysite mineral morphology affects the rheology of remoulded suspensions: tubular minerals have greater viscosity and undrained shear strength than spherical morphologies.
How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients
Authors: El Chaer Firas , Shah Dimpy P. , Chemaly Roy F. 
Published: October 2016

AbstractCytomegalovirus (CMV) infection is a significant complication in hematopoietic cell transplantation (HCT) recipients. Four antiviral drugs are used for preventing or treating CMV: ganciclovir, valganciclovir, foscarnet, and cidofovir. With prolonged and repeated use of these drugs, CMV can become resistant to standard therapy, resulting in increased morbidity and mortality, especially in HCT recipients. Antiviral drug resistance should be suspected when CMV viremia (DNAemia or antigenemia) fails to improve or continue to increase after 2 weeks of appropriately dosed and delivered antiviral therapy. CMV resistance is diagnosed by detecting specific genetic mutations. UL97 mutations confer resistance to ganciclovir and valganciclovir, and a UL54 mutation confers multidrug resistance. Risk factors for resistance include prolonged or previous anti-CMV drug exposure or inadequate dosing, absorption, or bioavailability. Host risk factors include type of HCT and degree of immunosuppression. Depending on the genotyping results, multiple strategies can be adopted to treat resistant CMV infections, albeit no randomized clinical trials exist so far, after reducing immunosuppression (if possible): ganciclovir dose escalation, ganciclovir and foscarnet combination, and adjunct therapy such as CMV-specific cytotoxic T-lymphocyte infusions. Novel therapies such as maribavir, brincidofovir, and letermovir should be further studied for treatment of resistant CMV.
Pneumococcal urinary antigen test use in diagnosis and treatment of pneumonia in seven Utah hospitals
Authors: West Devin M. , McCauley Lindsay M. , Sorensen Jeffrey S. , Jephson Al R. , Dean Nathan C. 
Published: October 2016

The pneumocococcal urine antigen test increases specific microbiological diagnosis over conventional culture methods in pneumonia patients. Data are limited regarding its yield and effect on antibiotic prescribing among patients with community-onset pneumonia in clinical practice.We performed a secondary analysis of 2837 emergency department patients admitted to seven Utah hospitals over 2 years with international diagnostic codes version 9 codes and radiographic evidence of pneumonia.Mean age was 64.2 years, 47.2% were male and all-cause 30-day mortality was 9.6%. Urinary antigen testing was performed in 1110 (39%) patients yielding 134 (12%) positives. Intensive care unit patients were more likely to undergo testing, and have a positive result (15%versus8.8% for ward patients; p<0.01). Patients with risk factors for healthcare-associated pneumonia had fewer urinary antigen tests performed, but 8.4% were positive. Physicians changed to targeted antibiotic therapy in 20 (15%) patients, de-escalated antibiotic therapy in 76 patients (57%). In 38 (28%) patients, antibiotics were not changed. Only one patient changed to targeted therapy suffered clinical relapse. Length of stay and mortality were lower in patients receiving targeted therapy.Pneumococcal urinary antigen testing is an inexpensive, noninvasive test that favourably influenced antibiotic prescribing in a “real world”, multi-hospital observational study.
Ex-vivo expansion of nonhuman primate CD34+ cells by stem cell factor Sall4B
Authors: Shen Bin , Zhang Yu , Dai Wei , Ma Yupo , Jiang Yongping 
Published: October 2016

Abstract
Background
Hematopoietic CD34+ stem cells are widely used in the clinical therapy of complicated blood diseases. Stem cell factor Sall4B is a zinc finger transcription factor that plays a vital role in hematopoietic stem cell expansion. The purpose of our current study is to further evaluate how Sall4B might affect the expansion of CD34+ cells derived from nonhuman primates.

Methods
Sall4B was overexpressed in nonhuman primate bone marrow-derived CD34+ cells via a lentiviral transduction system. The granulocyte–erythrocyte–macrophage–megakaryocyte colony-forming unit (CFU) assay evaluated the differentiation potential of primate CD34+ cells that were expanded with Sall4B. Furthermore, an in-vivo murine system was employed to evaluate the hematopoietic potential of primate Sall4B-expanded CD34+ cells.

Results
Overexpression of Sall4B promoted ex-vivo nonhuman primate CD34+ cell expansion by 9.21 ± 1.94-fold on day 9, whereas lentiviral transduction without Sall4B expanded cells by only 2.95 ± 0.77-fold. Sall4B maintained a significant percentage of CD34+ cells as well. The CFU assay showed that the Sall4B-expanded CD34+ cells still possessed multilineage differentiation potential. A study using nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mice in vivo revealed that Sall4B led to an increase in the number of repopulating cells and the 9-day-old Sall4B-transduced CD34+ cells still possess self-renewal and multilineage differentiation capacity in vivo, which are similar stemness characteristics to those in freshly isolated primate bone marrow-derived CD34+ cells.

Conclusions
We investigated the expansion of nonhuman primate bone marrow-derived CD34+ cells using the Sall4B lentiviral overexpression approach; our findings provide a new perspective on mechanisms of rapid stem cell proliferation. The utilization of Sall4B to expand CD34+ cells on a large scale through use of suitable model systems would prove helpful towards preclinical trials of autologous transplantation.
Discrepancy between short-term and long-term effects of bone marrow-derived cell therapy in acute myocardial infarction: a systematic review and meta-analysis
Authors: Lee Seon Heui , Hong Jin Hyuk , Cho Kyoung Hee , Noh Jin-Won , Cho Hyun-Jai 
Published: October 2016

Abstract
Background
Bone marrow-derived cell therapy has been used to treat acute myocardial infarction. However, the therapeutic efficacy of this approach remains controversial. Here, we performed a systematic review and meta-analysis to evaluate short-term and long-term effectiveness of bone marrow-derived therapy.

Methods
We searched eight databases (Ovid-Medline, Ovid-EMBASE, Cochrane Library, KoreaMed, KMBASE, KISS, RISS, and KisTi) up to December 2014. Demographic characteristics, clinical outcomes, and adverse events were analyzed. We identified 5534 potentially relevant studies; 405 were subjected to a full-text review. Forty-three studies with 2635 patients were included in this review.

Results
No safety issues related to cell injection were reported during follow-up. At 6 months, cell-injected patients showed modest improvements in left ventricular ejection fraction (LVEF) compared with the control group. However, there were no differences between groups at other time points. In the cardiac MRI analysis, there were no significant differences in infarct size reduction between groups. Interestingly, mortality tended to be reduced at the 3-year follow-up, and at the 5-year follow-up, cell injection significantly decreased all-cause mortality.

Conclusions
This meta-analysis demonstrated discrepancies between short-term LV functional improvement and long-term all-cause mortality. Future clinical trials should include long-term follow-up outcomes to validate the therapeutic efficacy of cell therapy.
Adopting incentive mechanisms for large-scale participation in mobile crowdsensing: from literature review to a conceptual framework
Authors: Ogie R. I. 
Published: October 2016

AbstractMobile crowdsensing is a burgeoning concept that allows smart cities to leverage the sensing power and ubiquitous nature of mobile devices in order to capture and map phenomena of common interest. At the core of any successful mobile crowdsensing application is active user participation, without which the system is of no value in sensing the phenomenon of interest. A major challenge militating against widespread use and adoption of mobile crowdsensing applications is the issue of how to identify the most appropriate incentive mechanism for adequately and efficiently motivating participants. This paper reviews literature on incentive mechanisms for mobile crowdsensing and proposes the concept of SPECTRUM as a guide for inferring the most appropriate type of incentive suited to any given crowdsensing task. Furthermore, the paper highlights research challenges and areas where additional studies related to the different factors outlined in the concept of SPECTRUM are needed to improve citizen participation in mobile crowdsensing. It is envisaged that the broad range of factors covered in SPECTRUM will enable smart cities to efficiently engage citizens in large-scale crowdsensing initiatives. More importantly, the paper is expected to trigger empirical investigations into how various factors as outlined in SPECTRUM can influence the type of incentive mechanism that is considered most appropriate for any given mobile crowdsensing initiative.
Circadian rhythms have significant effects on leaf-to-canopy scale gas exchange under field conditions
Authors: Resco de Dios Víctor , Gessler Arthur , Ferrio Juan Pedro , Alday Josu G , Bahn Michael , del Castillo Jorge , Devidal Sébastien , García-Muñoz Sonia , Kayler Zachary , Landais Damien , Martín-Gómez Paula , Milcu Alexandru , Piel Clément , Pirhofer-Walzl Karin , Ravel Olivier , Salekin Serajis , Tissue David T , Tjoelker Mark G , Voltas Jordi , Roy Jacques 
Published: October 2016

Abstract

Background
Molecular clocks drive oscillations in leaf photosynthesis, stomatal conductance, and other cell and leaf-level processes over ~24 h under controlled laboratory conditions. The influence of such circadian regulation over whole-canopy fluxes remains uncertain; diurnal CO2 and H2O vapor flux dynamics in the field are currently interpreted as resulting almost exclusively from direct physiological responses to variations in light, temperature and other environmental factors. We tested whether circadian regulation would affect plant and canopy gas exchange at the Montpellier European Ecotron. Canopy and leaf-level fluxes were constantly monitored under field-like environmental conditions, and under constant environmental conditions (no variation in temperature, radiation, or other environmental cues).

Results
We show direct experimental evidence at canopy scales of the circadian regulation of daytime gas exchange: 20–79 % of the daily variation range in CO2 and H2O fluxes occurred under circadian entrainment in canopies of an annual herb (bean) and of a perennial shrub (cotton). We also observed that considering circadian regulation improved performance by 8–17 % in commonly used stomatal conductance models.

Conclusions
Our results show that circadian controls affect diurnal CO2 and H2O flux patterns in entire canopies in field-like conditions, and its consideration significantly improves model performance. Circadian controls act as a ‘memory' of the past conditions experienced by the plant, which synchronizes metabolism across entire plant canopies.