bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Machine Learning Algorithms in the Analysis of Sentiments of E- Commerce Customer Reviews and Recommendations Feedback
Authors: Alrusaini Othman , Beyari Hasan 
Published: October 2024

Abstract

The aim of this research is to examine the use of machine learning models in the context of e-commerce customer reviews’ analysis, and more specifically, to classify customers’ recommendations based on textual feedback. The accumulation of a huge amount of unstructured big data reviews on the e-commerce platforms has a major drawback concerning the proper interpretation of the analyzed data, particularly in terms of the identification of overall customer sentiments. In the present study, we used a dataset of women’s clothing reviews and five classification algorithms, namely logistic regression, support vector machine, Naive Bayes, random forest, and light gradient boosting machine, and assessed their performance based on accuracy, precision, recall, and F1 score. The results show that the support vector machine model had the highest overall performance with 89.06% for accuracy and 90.49% for precision can be recommended for sentiment analysis with balanced performance. As for the results, logistic regression and light gradient boosting machine were also quite stable, especially in terms of precision and recall, while Naive Bayes and random forest were characterized by high recall and are good in identifying positive sentiment but with certain trade-offs in precision. The findings of the study are then compared with the previous literature for similarities and differences, especially with ensemble methods, such as random forest that had a fluctuating performance. The study finds that one model does not outperform the others, and the selection of the machine learning algorithm should be based on the characteristics of the dataset and the purpose of the analysis. Further studies are suggested to examine the utilization of deep learning models, the effect of elaborate preprocessing of data, and the concept of combining different models in order to improve the performance of sentiment analysis in the context of e-commerce.
Knowledge, Behavioural Lifestyle, and Preventive Measures of Myopia among Undergraduates in the University of Ibadan, Ibadan, Oyo State
Authors: Aroyehun Simon-P , Oluwasanu Mojisola Morenike 
Published: October 2024

Abstract

Background
Myopia, or short-sightedness, affects many young people globally. The condition has witnessed a significant increase, especially among adolescents and young adults. By 2050, almost half of the global population may suffer from it. The youth population, particularly in Nigeria, shows higher prevalence rates of myopia, necessitating investigations into knowledge, behavioural lifestyles, and prevention among undergraduates. The study examined the knowledge, behavioural lifestyle, and prevention strategies related to myopia among undergraduates in the University of Ibadan.
Methods
A cross-sectional survey was conducted at the University of Ibadan, among 401 undergraduates from 10 faculties selected through a multistage sampling technique. Data on knowledge of myopia, behavioural lifestyles, and preventive measures were collected using a semi-structured, self-administered questionnaire. Analysis was done using SPSS software, employing both descriptive and inferential statistics, which includes Chi-square and Kruskal-Wallis tests at α0.05 .
Results
Respondents’ age was 21.7 ± 2.8, 64.8% were males and 35.2% were females. About 53.9% of the respondents demonstrated good knowledge of myopia. Less than half, (46.5%) reported using digital devices for more than 3 hours daily without breaks, while 31.6% admitted to reading under dim light more than 5 times a week. Almost two-fifth of the respondents, (45.9%) demonstrated good preventive measures against myopia. Significant associations were identified between knowledge levels and socio-demographic characteristics, including age, gender, faculty, and monthly allowance. Additionally, there was an association between knowledge levels and lifestyle behaviours, and the practice of preventive measures.
Conclusion
The study showed that the University of Ibadan undergraduates have knowledge gaps about myopia, along with common lifestyle behaviours contributing to it. It also highlights the need for targeted educational interventions to improve undergraduates' knowledge about myopia, promote healthier lifestyle behaviours, and encourage the adoption of effective preventive measures among university students. To address these gaps, it's crucial to include myopia education in the General Studies (GST) curriculum. This should cover causes and prevention, and promote eye-friendly habits. Additionally, students should have easy access to eye care services. Collaboration between health professionals and the university is essential for a comprehensive approach to eye health education.
Shadow Economy or Economic Driver? The Impact of Counterfeiting on Italy's Growth
Authors: Beqiraj Elton , Fedeli Silvia , Giuriato Luisa 
Published: October 2024

Abstract

This study examines the impact of economic crime, specifically counterfeiting, on economic growth in Italy after the Great Recession (2008-19), when the country experienced lower economic growth than its developed counterparts. Counterfeiting is orchestrated by mafia-like organizations that turn large areas into hubs for the production/trading of counterfeit goods, thereby damaging genuine brands.
Our study, using a unique regional dataset, demonstrates that in Italy, two direct effects of counterfeiting are significant. First, it stimulates economic growth by flooding markets with counterfeit goods. Second, it undermines market modernization by violating the intellectual property rights of innovative firms in high-value sectors. Moreover, the resources absorbed by illegal activities determine an indirect negative effect: once counterfeiting is controlled, the standard drivers of economic development become more effective. This suggests that if all growth drivers were channeled into legal activities, Italy would experience a development path in line with the performance of its top competitor countries.
JEL: E26; O47; C23; K14
Sensory impairments and loneliness among older Europeans: Insights from a cross-national longitudinal study
Authors: Hansen Mathilde Sofie Schmidt , Lykkegaard Jesper , Möller Sören , Stokholm Lonny , Kjær Niels Kristian , Ahrenfeldt Linda Juel 
Published: October 2024

Abstract

Sensory impairments are linked to loneliness, but the reasons are not well understood. This study aims to investigate the associations between sensory impairments and loneliness over time, considering sex, age, and European regions, and to examine the mediating roles of activity participation, activities of daily living (ADL), depressive symptoms, quality of life (QoL), cognitive function, and social network. We conducted a cohort study of 83,329 Europeans aged 50 + years, participating in at least two waves of the Survey of Health, Ageing and Retirement in Europe (SHARE) from 2011–2022. Loneliness was measured on a scale from 3–9. Mixed-effects regression models with sex-interactions, adjusting for socio-demographic factors and medical history, were used. Compared to those with good vision and hearing, individuals with vision impairment (VI) (coef. = 0.12, 95% CI: 0.10; 0.14), hearing impairment (HI) (coef. = 0.11, 95% CI: 0.08; 0.14), and dual sensory impairment (DSI) (coef. = 0.28, 95% CI: 0.25; 0.31) had a higher risk of loneliness. Dose-response relationships were observed in all associations. Most associations were consistent across sex and age groups, but the association with HI was strongest for females up to age 79 years but only observed in males thereafter. Associations varied across Europe, with the strongest associations in Northern Europe for females with VI and males with HI. For DSI, the associations were mainly mediated by activity participation (17.4%), depressive symptoms (17.3%), and QoL (16.6%). To mitigate the effect of sensory impairments on loneliness, particularly limitations in activity participation should be targeted.
Healthcare-Seeking Behaviour for schistosomiasis-related signs and symptoms in Ghana’s capital
Authors: Appiaha David Boateng , Oduro Williams Ampadu , Lardy Linda Awinbel Akum 
Published: October 2024

Abstract

Background: Schistosomiasis, a parasitic disease spread through contaminated water, remains a significant public health challenge in areas with poor sanitation, including the Ga South Municipal District in Ghana. Despite preventive efforts by the World Health Organization, understanding the healthcare-seeking behavior for schistosomiasis symptoms is crucial to improving treatment outcomes.
Methods: A cross-sectional study was conducted in the Galilea and Mahem communities of the Ga South District, near a lake known for schistosomiasis transmission. A structured questionnaire was administered to 242 randomly selected household heads to assess their healthcare-seeking behavior when faced with schistosomiasis symptoms. Data were analyzed using SPSS version 21 to identify trends and patterns in behavior.
Results: Awareness of schistosomiasis was high among respondents, with 92.6% indicating familiarity with the disease. About 77.7% reported that they would seek treatment at hospitals or clinics if infected. The choice of healthcare facilities was largely influenced by the perceived efficacy of treatment. A significant association was found between the respondents' area of residence and their healthcare-seeking behavior (p=0.007), suggesting that location plays a crucial role in how individuals approach treatment.
Conclusions: The high awareness of schistosomiasis in the Galilea and Mahem communities is likely due to ongoing educational efforts. While most residents preferred formal healthcare settings, there is still a need to address the risks associated with self-medication through further education. Enhancing accessibility to healthcare facilities and continued public health education could improve timely treatment and reduce the disease burden.
Liposomal Nanoformulation-encapsulated Paclitaxel for Reducing Chemotherapy Side Effects in Lung Cancer Treatments: Recent Advances and Future Outlooks
Authors: Mohammad-Jafari Kave , Naghib Seyed Morteza , Mozafari M. R. 
Published: October 2024

Abstract:
Paclitaxel is one notable chemotherapy drug that is used to treat a number of
cancers, including lung cancer. Nevertheless, it has drawbacks such as toxicity, low solubility
in water, and the emergence of multidrug resistance (MDR). This article reviews
the use of liposomal formulations to improve paclitaxel administration and efficacy for
lung cancer therapy. Paclitaxel's pharmacological characteristics can be improved by liposomes
through increased solubility, extended circulation, passive tumor targeting
through leaky vasculature, and decreased side effects. Recent developments in paclitaxel
liposomal formulations, including as cationic liposomes, conventional liposomes, targeted
liposomes with particular ligands, and liposome-loaded microorganisms, are outlined
in this article. In comparison to free paclitaxel, these nanoformulations exhibit enhanced
cytotoxicity, cellular uptake, apoptosis, tumor growth suppression, and anticancer effects
in lung cancer cell lines and animal models. One efficient way to get around the
drawbacks of paclitaxel is to alter its size, makeup, and surface characteristics. This will
let the medication accumulate and penetrate tumors more easily, avoid multidrug resistance,
and cause less systemic toxicity. The article explores clinical studies showcasing
the safety and therapeutic efficacy of liposomal paclitaxel for individuals afflicted with
lung cancer. In its entirety, the document provides an in-depth examination of the potential
enhancement in paclitaxel's dispersion and anti-tumor impacts through the utilization
of liposomal technology when addressing diverse manifestations of lung cancer.
Development of a Mitochondrial Membrane Permeability Transition Prognosis System in Colon Adenocarcinoma: Risk Stratification and Therapeutic Target Identification
Authors: Zhang Bomiao , Xia Mingyu , Zhao Shihui , Li Yien , Yu Chenfeng , Song Liqiang , Wang Shaoke , Cui Binbin 
Published: October 2024

Aims:
Explore the role of mitochondrial membrane permeability transition
(MPT) in colon adenocarcinoma (COAD).

Background:
Further exploration of risk stratification for COAD prognostic assessment
has important clinical value. MPT-related pathways play a key role in the pathogenesis
of many human diseases, including tumorigenesis. Its impact on COAD is still unknown.

Objective:
Bioinformatics analysis was conducted by analyzing the GEO database and
TCGA database, and the bioinformatics results were verified by in vitro experiments.

Method:
Through the analysis of the transcriptome data of 1008 COAD samples in the
GEO database and TCGA database, the differential expressions of MPT-related genes in
COAD were explored, followed by molecular subtype analysis based on MPT characteristics
by univariate Cox algorithm analysis and the consensus clustering algorithm.
The gene signature associated with MPT molecular subtypes was further identified and
the MPT scoring system was established by the LASSO-univariate Cox analysis algorithm.
After evaluating the prognostic value of the MPT scoring system in COAD patients
via nomogram establishment, the clinical value of the MPT scoring system was
comprehensively analyzed through somatic mutation characteristics analysis, immunotherapy
response analysis, immunoinfiltration analysis, and drug sensitivity analysis.
CCK-8, WB, PCR, colony formation method, and Transwell method were used to
verify the effect of the screened target on the proliferation and invasion of COAD cells.

Result:
We successfully established a scoring system related to MPT and validated the
prognostic value of COAD patients. The potential clinical value of the MPT scoring system
was also analyzed. VSIG4 was selected for further in vitro experiments to verify the
effect of the screened targets on the proliferation and invasion ability of COAD cells.

Conclusions:
We established an MPT scoring system for effective risk stratification of
COAD patients, demonstrating the impact of MPT on the development of COAD and its
potential value as an intervention factor.
Jiangu Recipe Suppresses ER Stress-Induced Apoptosis and Inhibits Extracellular Matrix Degradation in Chondrocytes through Upregulating
SIRT1 Expression
Authors: Qiao Jie , Cheng Chang , Yang Gongxu , Zhong Chuanqi , Jin Jun , Wu Bin 
Published: October 2024

Objective:
This study aimed to explore the effects of Jiangu Recipe (JGR) on chondrocyte
responses under tert-Butyl hydroperoxide (TBHP)-induced oxidative stress, specifically
focusing on apoptosis and extracellular matrix (ECM) degradation.

Methods:
Chondrocytes were treated with varying JGR concentrations, and cell viability was
assessed. The impact of JGR on TBHP-induced apoptosis and protein expression levels of apoptosis-
related molecules (Bcl-2, Bax, and cleaved caspase-3) and ECM components (Collagen II,
Aggrecan, MMP-13) was evaluated.

Results:
JGR exhibited protective effects against oxidative stress in chondrocytes. Moreover, it
maintained cell viability under tert-butyl hydroperoxide (TBHP) induction, suppressing apoptosis
(Bax, cleaved caspase-3) and enhancing anti-apoptotic Bcl-2. JGR also attenuated extracellular
matrix (ECM) degradation, promoting Collagen II and Aggrecan while reducing MMP-13
expression. Investigating endoplasmic reticulum (ER) stress, it was found that JGR downregulated
TBHP-induced GRP78, CHOP, ATF4, p-PERK, and p-eIF2α, thus indicating ER stress
modulation. SIRT1 played a key role, as JGR upregulated SIRT1, mitigating TBHP-induced
downregulation. SIRT1 knockdown reversed JGR's protective effects, highlighting its crucial
role in JGR-mediated responses.

Conclusion:
Our findings suggest that JGR mitigated TBHP-induced chondrocyte apoptosis and
ECM degradation, highlighting its potential therapeutic application in osteoarthritis. Mechanistically,
our study highlights that SIRT1 plays a crucial role in mediating the protective effects of
JGR against ER stress-induced chondrocyte apoptosis and ECM degradation, providing a foundation
for further clinical exploration in managing osteoarthritic conditions.
Multi-Stimuli-Responsive Biocompatible Magnetic Nanocarrier as Drug Delivery System to MCF-7 Breast Cancer Cells
Authors: Ehsanimehr Sedigheh , Badr Kimya , Dehaen Wim , Irannejad Vahid Shafiei , Moghadam Peyman Najafi 
Published: October 2024

Introduction:
The last strategy in targeted drug delivery systems is to deliver the anticancer
drug to the tumor tissue to increase its therapeutic effect and minimize its undesirable side
effects. In line with this goal in this research, the redox/pH-responsive disulfide magnetic nanocarriers
based on PF127-NH2/L-cysteine-CM-β-CD-FA were synthesized and evaluated in a doxorubicin
delivery system.

Methods:
We effectively surrounded Fe3O4 nanoparticles with SiO2 using the sol-gel method, and
then confidently coated them with oleic acid on Fe3O4@SiO2 nanoparticles.. In another reaction, a
PF127-NH2/L-cysteine-CM-β-CD-FA was synthesized. The process involved modifying pluronic
F127 (PF 127) with maleic anhydride and aminating it to form PF127-NH2. The obtained PF127-NH2
was attached to L-cysteine, followed by condensing with carboxymethyl-β-cyclodextrin and then
functionalized by folic acid. Finally, PF127-NH2/L-cysteine-CM-β-CD-FA was coated on the surface
of magnetic nanoparticles, and the resulting PF127-NH2/L-cysteine-CM-β-CD-FA was disulfidated
to form the final nanocarrier network, which was abbreviated as LCMNPs-SS. The doxorubicin
was used as a model drug and loaded into the LCMNPs-SS nanocarrier.

Results:
The LCMNPs-SS nanocarrier exhibited excellent properties for controlled release, with a
well-defined release rate, a controllable level by an external magnet, and adjusting by DLdithiothreitol
concentration. The LCMNPs-SS nanocarrier could also break apart when exposed to an
oxidant or a change in pH. This meant that the drug release could be fine-tuned in response to temperature,
pH, or more than one stimulus.

Conclusion:
These drug-carrying systems are valuable in reducing the dose of doxorubicin. High
internalization of the synthesized LCMNPs-SS caused sped cellular uptake.
Approaches to Improve the Sleep Quality in Long Covid Patients: A Systematic Review
Authors: ShamsiKhani Soheila , Hosseini Mahsa 
Published: October 2024

Background:
Given the high prevalence of Long COVID, sleep problems have
emerged as a significant issue for individuals after COVID-19 infection, potentially impacting
their quality of life.

Objective:
Our study aims to identify effective strategies for improving sleep quality and offers recommendations
for future research.

Methods:
The present systematic review study investigated ways to improve sleep quality in
Long COVID patients. The study was conducted according to the updated PRISMA guidelines.
The risk of bias was assessed using ROB 2.0.

Results:
Finally, six articles were included in the present study to identify strategies for improving
and enhancing sleep quality in Long COVID. The results of the present study indicate that
various interventions have been carried out to improve sleep quality, including psychological, cognitive,
and physical factors related to long-term COVID-19 conditions.

Conclusion:
Based on existing evidence, interventions such as mind meditation, yoga, and hyperbaric
oxygen therapy have demonstrated efficacy in enhancing sleep quality among Long COVID
patients.
Bioactive Formulation and Bulk Allopurinol and Lycopene Estimation by UV Spectroscopy
Authors: Mishra Soumya , Harwansh Ranjit K. , Mazumder Rupa 
Published: October 2024

Background:
This study developed a UV spectrophotometric method for quantifying allopurinol and lycopene in both bulk and dosage forms, aiming for simplicity and practicality.

Materials and Methods:
The method was developed and validated using methanol and lyco-pene in phosphate buffer saline at various pH levels (7.4, 6.8, 1.2, 5.5). Validation parameters included linearity, accuracy, precision, limit of quantification (LOQ), and limit of detection (LOD) according to ICH standards.

Results:
The method demonstrated high sensitivity and linearity over a concentration range of 4-20 μg/ml, adhering to Beer's law. The LOQ and LOD were 2–18 μg/ml and 2–6 μg/ml, re-spectively. Optimal absorbance wavelengths were 251 nm for lycopene and 471 nm for allopu-rinol. Calibration curves showed a high correlation coefficient (0.9994), indicating a strong lin-ear relationship.

Conclusion:
The developed UV spectrophotometric method is effective, interference-free, and suitable for routine quality control, providing reliable measurements for allopurinol and lyco-pene.
Fixed Prosthodontic Rehabilitation of a Patient with Cleidocranial Dysplasia: A Case Report
Authors: Karakaya Merve , Çötert İrem , Yücel İrem Nur , Çötert H. Serdar 
Published: October 2024

Introduction
Cleidocranial Dysplasia (CCD) is a rare congenital disease characterized by skeletal and dental anomalies. Clinical findings of CCD patients include low facial height, pseudoprognathism, unerupted teeth, an excessive deep bite, chewing difficulties, and unsatisfied dentofacial appearance. These patients’ dental treatments present a substantial challenge.

Case Representation
This case report describes the prosthodontic treatment of a 29-year-old male CCD patient using porcelain-fused-to-metal restorations. The avoidance of a surgical procedure serves to minimize the potential for complications and expedites the attainment of outcomes with greater celerity. Throughout the follow-up period of 1 year, the patient maintained good periodontal health. The restoration of masticatory function and enhancement of facial esthetics were successfully achieved and the patient expressed a high degree of satisfaction with the outcome of the treatment.

Conclusion
The use of fixed prostheses in CCD patients is a treatment modality that resolves many of the issues caused by the surgical approach.