bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new reconstruction of continentalTreptichnusbased on exceptionally preserved material from the Jurassic of Massachusetts
Authors: Getty Patrick R. , McCarthy Thomas D. , Hsieh Shannon , Bush Andrew M. 
Published: June 2016

AbstractContinental deposits of the Early Jurassic East Berlin Formation in Holyoke, Massachusetts, have yielded an exceptional occurrence of the ichnogenusTreptichnus. Here, burrows are preserved in full relief within thin mud laminae between layers of fine-grained, cross-bedded sandstone. We studied these burrows to evaluate whether earlier explanations of burrow morphology are applicable to allTreptichnus. Our research focused on three questions. (1) Do the HolyokeTreptichnushave significant vertical relief? (2) Does the lack of projections in some of the HolyokeTreptichnusresult from stratinomic sectioning through the bottom of the burrow? (3) Do expanded, bulbous ends of burrow segments result from sediment compaction? While addressing these questions, the Holyoke fossils were compared to syntype and topotype material ofTreptichnusfrom the Carboniferous of Indiana. The HolyokeTreptichnusdid not exhibit significant vertical relief, and the presence and absence of projections is explained by the positioning of new segments at different points along older ones. The bulbous ends of burrow segments resulted from trace-maker behavior, not sediment compaction. Drawing on the analysis of the Holyoke material, a new reconstruction is proposed that presents continentalTreptichnusas a shallow mole-tunnel-like burrow produced just below the sediment surface. This reconstruction is consistent with the morphology of RecentTreptichnus-like burrows produced by fly (dipteran) larvae, which are considered the most likely makers of the HolyokeTreptichnus.
Low fruit consumption and omission of daily meals as risk factors for increased blood pressure in adults
Authors: Domingos Talita Barbosa , Pereira Avany Fernandes , Yokoo Edna Massae , Salles-Costa Rosana 
Published: June 2016

AbstractA population-based cross-sectional survey with cluster sampling design and with inverse sampling was conducted in 2010, in a sample of 1590 adults (19–60 years old) exposed to a high prevalence of food insecurity, in the municipality of Duque de Caxias, metropolitan region of Rio de Janeiro, Brazil. The objective of the study was to evaluate the association of socio-demographic factors, the consumption of fruits and vegetables and the number of meals with increased blood pressure (BP). A hierarchical model that considered variables related to the basic, intermediate and immediate determinants of increased BP was adopted. By using Poisson’s regression, univariate models were tested to obtain the prevalence ratio (PR) and its respective 95 % CI. After fitting the model, age (age group 50–59 years) (PR 1·62; 95 % CI 1·09, 2·41), low consumption of fruits in a week (PR 1·37; 95 % CI 1·07, 1·74), fewer meals per day (PR 1·72; 95 % CI 1·21, 2·43) and overweight (PR 1·78; 95 % CI 1·31, 2·20) remained significantly associated with increased BP. Therefore, the results found here reinforce the importance of encouraging and developing strategies that ensure access to healthy foods to minimise increased BP in similar populations.
The Language of Compromise in International Agreements
Authors: Linos Katerina , Pegram Tom 
Published: June 2016

AbstractTo reach agreement, international negotiators often compromise by using flexible language: they make controversial provisions vague, or add options and caveats. Does flexibility in agreement language influence subsequent state behavior? If so, do states follow both firm and flexible language somewhat, as negotiators hope? Or do governments respond strategically, increasing their energies on firmly specified tasks, and reducing their efforts on flexibly specified ones? Testing theories about agreement language is difficult because states often reserve flexible language for controversial provisions. To make causal claims, we study an unusually drafted agreement in which states had almost no opportunity to dilute agreement language. We examine the influence of the 1991 Paris Principles on the Design of National Human Rights Institutions (NHRIs), using an original data set of twenty-two institutional safeguards of NHRIs in 107 countries, and case studies. We find that variations in agreement language can have large effects on state behavior, even when the entire agreement is nonbinding. Both democracies and authoritarian states followed the principles' firm terms closely. However, authoritarian states either ignored or reduced their efforts on flexibly specified tasks. If flexibly specifying a task is no different from omitting it altogether, as our data suggest, the costs of compromise are much greater than previously believed.
Beyond risk: Prospective effects of GABA Receptor Subunit Alpha-2 (GABRA2) × Positive Peer Involvement on adolescent behavior
Authors: Trucco Elisa M. , Villafuerte Sandra , Burmeister Margit , Zucker Robert A. 
Published: June 2016

AbstractResearch on Gene × Environment interactions typically focuses on maladaptive contexts and outcomes. However, the same genetic factors may also impact susceptibility to positive social contexts, leading to adaptive behavior. This paper examines whether the GABA receptor subunit alpha-2 (GABRA2) single nucleotide polymorphism rs279858 moderates the influence of positive peer affiliation on externalizing behavior and various forms of competence. Regions of significance were calculated to determine whether the form of the interaction supported differential susceptibility (increased sensitivity to both low and high positive peer affiliation) or vantage sensitivity (increased sensitivity to high positive peer affiliation). It was hypothesized that those carrying the homozygous minor allele (GG) would be more susceptible to peer effects. A sample (n = 300) of primarily male (69.7%) and White (93.0%) adolescents from the Michigan Longitudinal Study was assessed from ages 12 to 17. There was evidence for prospective Gene × Environment interactions in three of the four models. At low levels of positive peer involvement, those with the GG genotype were rated as having fewer adaptive outcomes, while at high levels they were rated as having greater adaptive outcomes. This supports differential susceptibility. Conceptualizing GABRA2 variants as purely risk factors may be inaccurate. Genetic differences in susceptibility to adaptive environmental exposures warrants further investigation.
Definiteil y a-clefts in spoken French
Authors: VERWIMP LYAN , LAHOUSSE KAREN 
Published: June 2016

ABSTRACTThis article discussesil y a-clefts in spoken French. In the linguistic literature, only one function ofil y a-clefts is widely acknowledged, namely presenting a new event in the discourse. By studying corpus examples in their wider context, we found however that many occurrences do not easily fit in the properties described in the literature. We make a distinction between presentationalil y a-clefts, which can be event-presenting or entity-presenting, and specificational enumerativeil y a-clefts, which give an example of a class that was implicitly or explicitly evoked in the context.
Comparison of different measures of obesity in their association with health-related quality of life in older adults – results from the KORA-Age study
Authors: Riedl Anna , Vogt Susanne , Holle Rolf , de las Heras Gala Tonia , Laxy Michael , Peters Annette , Thorand Barbara 
Published: June 2016

AbstractObjectiveAs ageing is associated with changes in body composition, BMI may not be the appropriate obesity measure for older adults. To date, little is known about associations between obesity measures and health-related quality of life (HRQoL). Thus, we aimed to compare different obesity measures in their association with HRQoL and self-rated physical constitution (SRPC) in older adults.DesignSeven obesity measures (BMI, waist circumference (WC), waist-to-hip ratio, waist-to-height ratio, fat mass percentage based on bioelectrical impedance analysis, hypertriglyceridaemic waist (HTGW) and sarcopenic obesity) were assessed at baseline in 2009. HRQoL, using the EQ-5D questionnaire, and SRPC, using one single question, were collected at baseline and at the 3-year follow-up in 2012. Linear and logistic regression analyses were used to examine the associations between the obesity measures and both outcomes. Model comparisons were conducted by area under the receiver-operating characteristic curve, R2, Akaike and Schwarz Bayesian information criteria.SettingKORA-Age study in Southern Germany (2009–2012).SubjectsOlder adults (n 883; aged ≥65 years).ResultsNearly all obesity measures were significantly inversely associated with both outcomes in cross-sectional analyses. Concerning HRQoL, the WC model explained most of the variance and had the best model adaption, followed by the BMI model. Regarding SRPC, the HTGW and BMI models were best as rated by model quality criteria, followed closely by the WC model. Longitudinal analyses showed no significant associations.ConclusionsThese results suggest that, with regard to HRQoL/SRPC, simple anthropometric measures are sufficient to determine obesity in older adults in medical practice.
Mimetite Formation from Goethite-Adsorbed Ions
Authors: Kleszczewska-Zębala Anna , Manecki Maciej , Bajda Tomasz , Rakovan John , Borkiewicz Olaf J. 
Published: June 2016

AbstractBioavailability of arsenic in contaminated soils and wastes can be reduced to insignificant levels by precipitation of mimetite Pb5(AsO4)3Cl. The objective of this study is to elucidate mechanisms of the reaction between solution containing lead ions and arsenates adsorbed on synthetic goethite (AsO4-goethite), or arsenate ions in the solution and goethite saturated with adsorbed Pb (Pb-goethite). These reactions, in the presence of Cl, result in rapid crystallization of mimetite. Formation of mimetite is faster than desorption of AsO4 but slower than desorption of Pb from the goethite surface. Slow desorption of arsenates from AsO4-goethite results in heterogeneous precipitation and formation of mimetite incrustation on goethite crystals. Desorption of lead from Pb-goethite is at least as fast as diffusion and advection of AsO4 and Cl in suspension allowing for homogeneous crystallization of mimetite in intergranular solution. Therefore, the mechanism of nucleation is primarily driven by the kinetics of constituent supply to the saturation front, rather than by the thermodynamics of nucleation. The products of the reactions are well documented using microscopy methods such as scanning electron microscopy, electron backscattered diffraction, X-ray diffraction, and Fourier transform infrared spectroscopy.
Implementing Transmission Electron Backscatter Diffraction for Atom Probe Tomography
Authors: Rice Katherine P. , Chen Yimeng , Prosa Ty J. , Larson David J. 
Published: June 2016

AbstractThere are advantages to performing transmission electron backscattering diffraction (tEBSD) in conjunction with focused ion beam-based specimen preparation for atom probe tomography (APT). Although tEBSD allows users to identify the position and character of grain boundaries, which can then be combined with APT to provide full chemical and orientation characterization of grain boundaries, tEBSD can also provide imaging information that improves the APT specimen preparation process by insuring proper placement of the targeted grain boundary within an APT specimen. In this report we discuss sample tilt angles, ion beam milling energies, and other considerations to optimize Kikuchi diffraction pattern quality for the APT specimen geometry. Coordinated specimen preparation and analysis of a grain boundary in a Ni-based Inconel 600 alloy is used to illustrate the approach revealing a 50° misorientation and trace element segregation to the grain boundary.
Spontaneous incorporation of gold in palladium-based ternary nanoparticles makes durable electrocatalysts for oxygen reduction reaction
Authors: Wang Deli , Liu Sufen , Wang Jie , Lin Ruoqian , Kawasaki Masahiro , Rus Eric , Silberstein Katharine E. , Lowe Michael A. , Lin Feng , Nordlund Dennis , Liu Hongfang , Muller David A. , Xin Huolin L. , Abruña Héctor D. 
Published: June 2016

AbstractReplacing platinum by a less precious metal such as palladium, is highly desirable for lowering the cost of fuel-cell electrocatalysts. However, the instability of palladium in the harsh environment of fuel-cell cathodes renders its commercial future bleak. Here we show that by incorporating trace amounts of gold in palladium-based ternary (Pd6CoCu) nanocatalysts, the durability of the catalysts improves markedly. Using aberration-corrected analytical transmission electron microscopy in conjunction with synchrotron X-ray absorption spectroscopy, we show that gold not only galvanically replaces cobalt and copper on the surface, but also penetrates through the Pd–Co–Cu lattice and distributes uniformly within the particles. The uniform incorporation of Au provides a stability boost to the entire host particle, from the surface to the interior. The spontaneous replacement method we have developed is scalable and commercially viable. This work may provide new insight for the large-scale production of non-platinum electrocatalysts for fuel-cell applications.
Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes
Authors: Barrow-McGee Rachel , Kishi Naoki , Joffre Carine , Ménard Ludovic , Hervieu Alexia , Bakhouche Bakhouche A. , Noval Alejandro J. , Mai Anja , Guzmán Camilo , Robbez-Masson Luisa , Iturrioz Xavier , Hulit James , Brennan Caroline H. , Hart Ian R. , Parker Peter J. , Ivaska Johanna , Kermorgant Stéphanie 
Published: June 2016

AbstractReceptor tyrosine kinases (RTKs) and integrins cooperate to stimulate cell migration and tumour metastasis. Here we report that an integrin influences signalling of an RTK, c-Met, from inside the cell, to promote anchorage-independent cell survival. Thus, c-Met and β1-integrin co-internalize and become progressively recruited on LC3B-positive ‘autophagy-related endomembranes’ (ARE). In cells growing in suspension, β1-integrin promotes sustained c-Met-dependent ERK1/2 phosphorylation on ARE. This signalling is dependent on ATG5 and Beclin1 but not on ATG13, suggesting ARE belong to a non-canonical autophagy pathway. This β1-integrin-dependent c-Met-sustained signalling on ARE supports anchorage-independent cell survival and growth, tumorigenesis, invasion and lung colonization in vivo. RTK–integrin cooperation has been assumed to occur at the plasma membrane requiring integrin ‘inside-out’ or ‘outside-in’ signalling. Our results report a novel mode of integrin–RTK cooperation, which we term ‘inside-in signalling’. Targeting integrin signalling in addition to adhesion may have relevance for cancer therapy.
Correlation and anti-correlation of the East Asian summer and winter monsoons during the last 21,000 years
Authors: Wen Xinyu , Liu Zhengyu , Wang Shaowu , Cheng Jun , Zhu Jiang 
Published: June 2016

AbstractUnderstanding the past significant changes of the East Asia Summer Monsoon (EASM) and Winter Monsoon (EAWM) is critical for improving the projections of future climate over East Asia. One key issue that has remained outstanding from the paleo-climatic records is whether the evolution of the EASM and EAWM are correlated. Here, using a set of long-term transient simulations of the climate evolution of the last 21,000 years, we show that the EASM and EAWM are positively correlated on the orbital timescale in response to the precessional forcing, but are anti-correlated on millennial timescales in response to North Atlantic melt water forcing. The relation between EASM and EAWM can differ dramatically for different timescales because of the different response mechanisms, highlighting the complex dynamics of the East Asian monsoon system and the challenges for future projection.
Demographic routes to variability and regulation in bird populations
Authors: Sæther Bernt-Erik , Grøtan Vidar , Engen Steinar , Coulson Tim , Grant Peter R. , Visser Marcel E. , Brommer Jon E. , Rosemary Grant B. , Gustafsson Lars , Hatchwell Ben J. , Jerstad Kurt , Karell Patrik , Pietiäinen Hannu , Roulin Alexandre , Røstad Ole W. , Weimerskirch Henri 
Published: June 2016

AbstractThere is large interspecific variation in the magnitude of population fluctuations, even among closely related species. The factors generating this variation are not well understood, primarily because of the challenges of separating the relative impact of variation in population size from fluctuations in the environment. Here, we show using demographic data from 13 bird populations that magnitudes of fluctuations in population size are mainly driven by stochastic fluctuations in the environment. Regulation towards an equilibrium population size occurs through density-dependent mortality. At small population sizes, population dynamics are primarily driven by environment-driven variation in recruitment, whereas close to the carrying capacityK, variation in population growth is more strongly influenced by density-dependent mortality of both juveniles and adults. Our results provide evidence for the hypothesis proposed by Lack that population fluctuations in birds arise from temporal variation in the difference between density-independent recruitment and density-dependent mortality during the non-breeding season.
Reconfigurable optical assembly of nanostructures
Authors: Montelongo Yunuen , Yetisen Ali K. , Butt Haider , Yun Seok-Hyun 
Published: June 2016

AbstractArrangements of nanostructures in well-defined patterns are the basis of photonic crystals, metamaterials and holograms. Furthermore, rewritable optical materials can be achieved by dynamically manipulating nanoassemblies. Here we demonstrate a mechanism to configure plasmonic nanoparticles (NPs) in polymer media using nanosecond laser pulses. The mechanism relies on optical forces produced by the interference of laser beams, which allow NPs to migrate to lower-energy configurations. The resulting NP arrangements are stable without any external energy source, but erasable and rewritable by additional recording pulses. We demonstrate reconfigurable optical elements including multilayer Bragg diffraction gratings, volumetric photonic crystals and lenses, as well as dynamic holograms of three-dimensional virtual objects. We aim to expand the applications of optical forces, which have been mostly restricted to optical tweezers. Holographic assemblies of nanoparticles will allow a new generation of programmable composites for tunable metamaterials, data storage devices, sensors and displays.
Modularity and stability in ecological communities
Authors: Grilli Jacopo , Rogers Tim , Allesina Stefano 
Published: June 2016

AbstractNetworks composed of distinct, densely connected subsystems are called modular. In ecology, it has been posited that a modular organization of species interactions would benefit the dynamical stability of communities, even though evidence supporting this hypothesis is mixed. Here we study the effect of modularity on the local stability of ecological dynamical systems, by presenting new results in random matrix theory, which are obtained using a quaternionic parameterization of the cavity method. Results show that modularity can have moderate stabilizing effects for particular parameter choices, while anti-modularity can greatly destabilize ecological networks.
UK prescribing practices as proxy markers of unmet need in allergic rhinitis: a retrospective observational study
Authors: Price David B , Scadding Glenis , Bachert Claus , Saleh Hesham , Nasser Shuaib , Carter Victoria , von Ziegenweidt Julie , Durieux Alice M S , Ryan Dermot 
Published: June 2016

AbstractLittle data on UK prescribing patterns and treatment effectiveness for allergic rhinitis (AR) are available. We quantified unmet pharmacologic needs in AR by assessing AR treatment effectiveness based on the prescribing behaviour of UK general practitioners (GP) during two consecutive pollen seasons (2009 and 2010). We conducted a retrospective observational study with the data from the Optimum Patient Care Research Database. We assessed diagnoses and prescription data for patients with a recorded diagnosis of rhinitis who took rhinitis medication during the study period. We assessed the data from 25,069 patients in 2009 and 22,381 patients in 2010. Monotherapy was the initial prescription of the season for 67% of patients with seasonal AR (SAR) and 77% of patients with nonseasonal upper airways disease (NSUAD), for both years. Initial oral antihistamine (OAH) or intranasal corticosteroid (INS) monotherapy proved insufficient for >20% of SAR and >37% of NSUAD patients. Multiple therapy was the initial prescription for 33% of SAR and 23% of NSUAD in both years, rising to 45% and >50% by season end, respectively. For NSUAD, dual-therapy prescriptions doubled and triple-therapy prescriptions almost tripled during both seasons. Many patients revisited their GP regardless of initial prescription. Initial OAH or INS monotherapy provides insufficient symptom control for many AR patients. GPs often prescribe multiple therapies at the start of the season, with co-prescription becoming more common as the season progresses. However, patients prescribed multiple therapies frequently revisit their GP, presumably to adjust treatment. These data suggest the need for more effective AR treatment and management strategies.
Functional characterization of three trehalase genes regulating the chitin metabolism pathway in rice brown planthopper using RNA interference
Authors: Zhao Lina , Yang Mengmeng , Shen Qida , Liu Xiaojun , Shi Zuokun , Wang Shigui , Tang Bin 
Published: June 2016

AbstractRNA interference (RNAi) is an effective gene-silencing tool and double stranded RNA (dsRNA) is considered a powerful strategy for gene function studies in insects. In the present study, we aimed to investigate the function of trehalase (TRE) genes (TRE 1-1, TRE 1-2 and TRE-2) isolated from the brown planthopper Nilaparvata lugens, a typical piercing-sucking insect in rice and investigate their regulating roles in chitin synthesis by injecting larvae with dsRNA. The results showed that TRE1 and TRE2 had compensatory function and the expression of each increased when the other was silenced. The total rate of insects with phenotypic deformities ranged from 19.83 to 24.36% after dsTRE injection, whereas the mortality rate ranged from 14.16 to 31.78%. The mRNA levels of genes involved in the chitin metabolism pathway in RNA-Seq and DGEP, namely hexokinase (HK), glucose-6-phosphate isomerase (G6PI) and chitinase (Cht), decreased significantly at 72 h after single dsTREs injection, whereas two transcripts of chitin synthase (CHS) genes decreased at 72 h after dsTRE1-1 and dsTREs injection. These results demonstrated that TRE silencing could affect the regulation of chitin biosynthesis and degradation, causing moulting deformities. Therefore, expression inhibitors of TREs might be effective tools for the control of planthoppers in rice.