bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: AIBN/NaBr‐Promoted Aerobic Oxidation of Benzylic Alcohols via a Radical Process.
Authors: Liu Chengkou , Fang Zheng , Yang Zhao , Li Qingwen , Guo Shiyu , Guo Kai 
Published: April 2016

AbstractA green and economic aerobic oxidation of benzylic, (hetero)aryl, and allyl alcohols is developed.
ChemInform Abstract: A Novel Protocol for the One‐Pot Borylation/Suzuki Reaction Provides Easy Access to Hinge‐Binding Groups for Kinase Inhibitors.
Authors: Hooper A. , Zambon A. , Springer C. J. 
Published: April 2016

AbstractAn one‐pot sequence of borylation and Suzuki reaction is used for the preparation of 20 bi‐ and polyarenes, e.g. vemurafenib precursor (IIId) and analogues (V) of kinase inhibitor GDC‐0879.
ChemInform Abstract: C—C Activation by Retro‐Aldol Reaction of Two β‐Hydroxy Carbonyl Compounds: Synergy with Pd‐Catalyzed Cross‐Coupling to Access Mono‐α‐Arylated Ketones and Esters.
Authors: Zhang Song‐Lin , Yu Ze‐Long 
Published: April 2016

AbstractThe cross‐coupling reaction of aryl halides with aldol‐type ketones and esters produces selectively mono‐α‐arylated ketones and esters.
ChemInform Abstract: DMF‐Mediated Deprotection of Bulky Silyl Esters under Neutral and Fluoride‐Free Conditions.
Authors: Chen Bo , Sun Hui‐Xia , Qin Jian‐Feng , Wang Bing 
Published: April 2016

AbstractThis simple protocol allows the cleavage of a wide range of bulky silyl esters and tolerates various acid and base labile functional groups.
ChemInform Abstract: Synthesis of 2,5‐Epoxy‐1,4‐benzoxazepines via Rhodium(II)‐Catalyzed Reaction of 1‐Tosyl‐1,2,3‐triazoles and Salicylaldehydes.
Authors: Meng Jiang , Ding Xiangfeng , Yu Xingxin , Deng Wei‐Ping 
Published: April 2016

AbstractThe title synthesis probably follows an α‐Imino carbene formation/[3 + 2]‐cycloaddition/ring opening/ring closing sequence.
ChemInform Abstract: One Pot Oxidative N—S Bond Formation to Access 2‐Sulfenylimine Chromenes.
Authors: Kale Ashok , Chennapuram Madhu , Bingi Chiranjeevi , Nanubolu Jagadeesh Babu , Atmakur Krishnaiah 
Published: April 2016

AbstractThe simple, efficient and one‐pot, catalyst‐free protocol leads to the synthesis of new 2‐sulfenylimine chromene compounds.
ChemInform Abstract: Asymmetric α,γ‐Regioselective [3 + 3] Formal Cycloadditions of α,β‐Unsaturated Aldehydes via Cascade Dienamine—Dienamine Catalysis.
Authors: Xiao Wei , Yin Xiang , Zhou Zhi , Du Wei , Chen Ying‐Chun 
Published: April 2016

AbstractThe title reaction between α,β‐unsaturated aldehydes and 2‐nitroallylic acetates followed by base‐mediated epimerization provides multifunctionalized cyclohexene derivatives in moderate yields and with excellent enantioselectivities as trans‐diastereomers, and cis‐diastereomers may be isolated upon omitting epimerization.
ChemInform Abstract: A Protocol for Amide Bond Formation with Electron Deficient Amines and Sterically Hindered Substrates.
Authors: Due‐Hansen Maria E. , Pandey Sunil K. , Christiansen Elisabeth , Andersen Rikke , Hansen Steffen V. F. , Ulven Trond 
Published: April 2016

AbstractA method for efficient in situ coupling of sterically hindered carboxylic acids with hindered or electron deficient amines and oxazolidinones is developed.
ChemInform Abstract: Selective Direct N‐Alkylation of Amines with Alcohols Using Iron(III) Phthalocyanine Chloride under Solvent‐Free Conditions.
Authors: Minakawa Maki , Okubo Masataka , Kawatsura Motoi 
Published: April 2016

AbstractN‐alkyl amines are prepared with excellent selectivity by mono‐alkylation of various primary aromatic amines with benzyl alcohols using microwave irradiation.
ChemInform Abstract: Regioselective Rhodium‐Catalyzed Addition of 1,3‐Dicarbonyl Compounds to Terminal Alkynes.
Authors: Beck Thorsten M. , Breit Bernhard 
Published: April 2016

AbstractThe title reaction has a broad substrate scope and provides valuable branched α‐allylated 1,3‐dicarbonyl compounds in often very high yields.
ChemInform Abstract: Unprecedented Reaction of Ninhydrin with Ethyl Cyanoacetate and Diethyl Malonate on Ultrasonic Irradiation.
Authors: Saini Yeshwinder , Khajuria Rajni , Rana Love Karan , Hundal Geeta , Gupta Vivek K. , Kant Rajni , Kapoor Kamal K. 
Published: April 2016

AbstractIn addition to the title reactions, ninhydrin is also transformed with ethyl acetonate, ethyl nitroacetate, and dimedone.
ChemInform Abstract: Facile Synthesis of Functionalized 6‐Cyano‐2‐oxa‐7‐azabicyclo[4.1.0]hept‐3‐en‐1‐yl Acetates: A Catalyst Free Approach to Access the Pyran Fused 2‐Acetoxy‐NH‐aziridines.
Authors: Mukherjee Prasun , Das Asish R. 
Published: April 2016

AbstractThe highly functionalized products are obtained following a one‐step reaction of 4H‐pyrans or spiropyrans with iodobenzene diacetate without aid of any other reagent or catalyst.
ChemInform Abstract: A Fortuitously Straightforward Synthesis of 4‐Acetoxy‐2‐propyltetrahydrothiophene.
Authors: Ma Bianbian , Yang Shaoxiang , Tao Feiyan , Sun Baoguo , Liu Yongguo , Tian Hongyu 
Published: April 2016

AbstractThe title tetrahydrothiophene is synthesized by a three‐step procedure involving a known epoxidation step of 1‐hepten‐4‐ol and subsequent mesylation and acetoxylation‐ring closing reactions.
ChemInform Abstract: Palladium‐Catalyzed Propargylative and Allenylative Dearomatization of 2‐(Chloromethyl)thiophenes: Remarkable Effect of Solvents.
Authors: Ullah Aziz , Zhang Sheng , Bao Ming , Yamamoto Yoshinori , Almansour Abdulrahman I. , Arumugam Natarajan , Kumar Raju Suresh 
Published: April 2016

AbstractThe title reaction affords only propargylic compounds in coordinating solvent MeCN, but gives allenic compounds as major products in uncoordinating solvent CH2Cl2.
ChemInform Abstract: An Efficient Route to Regioselective Functionalization of Benzo[b]thiophenes via Palladium‐Catalyzed Decarboxylative Heck Coupling Reactions: Insights from Experiment and Computation.
Authors: Yang Daoshan , Liu Yuxia , Sun Pengfei , Zhang Ning , Wei Wei , Sun Mingyang , Chen Guang , Bi Siwei , Wang Hua 
Published: April 2016

AbstractThe decarboxylative Heck coupling reaction of 3‐chlorobenzo[b]thiophene‐2‐carboxylic acids (I) with styrenes leads to desired (E)‐3‐chloro‐2‐styrylbenzo[b]thiophenes (III) in good to high yields, while the reactions with 1‐pentene and methyl acrylate fail.
ChemInform Abstract: One‐Pot Synthesis of 14‐Aryl‐14 H‐Dibenzo[a,j]xanthene Derivatives Catalyzed by Nano‐Alumina Sulfuric Acid Through Solvent‐Free Conditions.
Authors: Davod Fereshteh , Kiasat Ali R. , Enjilzadeh Marzieh , Cheraghchi Mina 
Published: April 2016

AbstractAn environmentally friendly method for preparation of the title xanthenes by multicomponent condensation of naphthol and aromatic benzaldehydes in short times and high yield is developed.
ChemInform Abstract: Regioselective α‐Arylation of Coumarins and 2‐Pyridones with Phenylhydrazines under Transition‐Metal‐Free Conditions.
Authors: Chauhan Parul , Ravi Makthala , Singh Shikha , Prajapati Prashant , Yadav Prem P. 
Published: April 2016

AbstractIn addition to coumarins and N‐methyl or N‐unprotected 2‐pyridones the reaction is also applied to aza‐coumarins.
ChemInform Abstract: Cobalt‐Catalyzed Carbonylative Cyclization of Pyridinyl Diazoacetates for the Synthesis of Pyridoisoquinolinones.
Authors: Baek Yonghyeon , Kim Sunghwa , Jeon Bongkeun , Lee Phil Ho 
Published: April 2016

AbstractThe title reaction is extended to a semi‐one‐pot transformation of ethylpyridinyl aryl acetates into pyridoisoquinolinones.
ChemInform Abstract: Catalytic Enantioselective Synthesis of N—C Axially Chiral Phenanthridin‐6‐one Derivatives.
Authors: Hirata Tomoaki , Takahashi Isao , Suzuki Yuya , Yoshida Hiroaki , Hasegawa Hiroshi , Kitagawa Osamu 
Published: April 2016

AbstractPhenanthridinone derivatives bearing ortho‐substituted phenyl groups on the nitrogen atom are enantioselectively obtained by a palladium/Segphos‐catalyzed intramolecular Buchwald—Hartwig amination.
ChemInform Abstract: Silica—ZnCl2: An Efficient and Reusable Solid Catalyst for One Pot Synthesis of 5‐Methyl Mercaptothiocarbonyl‐4‐aryl‐3‐dihydropyrimidin‐2(1H)‐ones under Solvent‐Free Conditions.
Authors: Devi Laishram Ronibala , Chanu Leimajam Vartima , Choi Hojune , Lee Dahyun , Singh Okram Mukherjee , Lee Sang‐Gyeong 
Published: April 2016

AbstractAn eco‐friendly method is developed for preparation of the title compounds by one‐pot three‐component reaction of β‐oxodithiocarboxylates, benzaldehydes, and urea.
ChemInform Abstract: Reaction of Elemental Phosphorus with α‐Methylstyrenes: One‐Pot Synthesis of Secondary and Tertiary Phosphines, Prospective Bulky Ligands for Pd(II) Catalysts.
Authors: Trofimov Boris A. , et al.  
Published: April 2016

AbstractDepending on the reaction conditions, the one‐pot transformation of α‐methylstyrenes with red phosphorus gives secondary and tertiary phosphines or phosphinic acids.
ChemInform Abstract: Copper‐Catalyzed One‐Pot Tandem Synthesis of Unsymmetrical Diaryl Chalcogenides from Two Different Aryl Iodides.
Authors: Zhang Shaozhong , Koe Adam , Heintz Christina , Senior Aunajay , Jin Jin 
Published: April 2016

AbstractCoupling of aryl iodides with elemental selenium or tellurium affords symmetrical diaryl dichalcogenide intermediates which are further converted to unsymmetrical diaryl chalcogenides through the reaction with different aryl iodides.
ChemInform Abstract: Synthesis of D‐Desosamine and Analogues by Rapid Assembly of 3‐Amino Sugars.
Authors: Zhang Ziyang , Fukuzaki Takehiro , Myers Andrew G. 
Published: April 2016

AbstractKey step in the synthesis of D‐desosamine and analogs (V) is the chromatography‐free procedure for the coupling of chiral nitrobutanols (I) with glyoxal to give pure 3‐nitro sugars by crystallization.
ChemInform Abstract: Total Synthesis of (‐)‐Hymenosetin.
Authors: Kauhl Ulrich , Andernach Lars , Weck Stefan , Sandjo Louis P. , Jacob Stefan , Thines Eckhard , Opatz Till 
Published: April 2016

AbstractHymenosetin (I) and its N‐methyl analogue are prepared in 11 and 8 steps, respectively, from citronellal employing an intramolecular Diels‐Alder reaction as the key step.
ChemInform Abstract: Filling the Gap Between the Quantum and Classical Worlds of Nanoscale Magnetism: Giant Molecular Aggregates Based on Paramagnetic 3d Metal Ions
Authors: Papatriantafyllopoulou Constantina , Moushi Eleni E. , Christou George , Tasiopoulos Anastasios J. 
Published: April 2016

AbstractReview: [syntheses, structures and magnetic properties of giant molecular 3d and 3d/4f paramagnetic metal clusters; 79 refs.
Solution‐Based Chemical Process for Synthesis of Highly Active Li2S/Carbon Nanocomposite for Lithium‐Sulfur Batteries
Authors: Strubel Patrick , Althues Holger , Kaskel Stefan 
Published: April 2016

AbstractA novel method for the preparation of Li2S integrated into porous carbon black as host material by using a facile solution‐based chemical process is described. Li2S was synthesized by disproportionation of a Li2S6 polysulfide solution. The combination of a homogeneous Li2S distribution with small Li2S particle size and good contact with the carbon surface leads to ideal properties for the application in high‐energy‐density long‐cycle‐life lithium‐sulfur batteries. An initial discharge capacity of 1259 mA h g−1sulfur with good cycle stability as well as low polarization are achieved, rendering the novel method particularly suitable for application in full cells with silicon‐ or carbon‐based anodes, which are used to overcome the main limitations observed using metallic lithium as anode in lithium‐sulfur batteries.
Conversion of Xylose to Furfuryl Alcohol and 2‐Methylfuran in a Continuous Fixed‐Bed Reactor
Authors: Cui Jinglei , Tan Jingjing , Cui Xiaojing , Zhu Yulei , Deng Tiansheng , Ding Guoqiang , Li Yongwang 
Published: April 2016

AbstractAn efficient process was designed for the synthesis of furfuryl alcohol and 2‐methylfuran from xylose using a continuous fixed‐bed reactor over a catalyst combining Hβ zeolite and Cu/ZnO/Al2O3 in γ‐butyrolactone (GBL)/water as solvent. The cooperative effect of Hβ zeolite and GBL facilitated the dehydration of xylose and enhanced largely the furfural yield. The production of furfuryl alcohol and 2‐methylfuran can be simply tuned by changing the hydrogenation temperature for furfural over the Cu/ZnO/Al2O3 catalyst. The yield for furfuryl alcohol reached 87.2 % at 150 °C whereas a yield of 86.8 % was achieved for 2‐methylfuran at 190 °C.
The Energy‐Autocorrelation Function in Magnetized and Unmagnetized Strongly Coupled Plasmas
Authors: Ott T. , Donkó Z. , Bonitz M. 
Published: April 2016

AbstractThe energy‐autocorrelation function is calculated for a screened Coulomb system in equilibrium and the contributions of different energy transport channels to the total heat conductivity are explored for magnetized and unmagnetized systems. A special focus is on the time scales of the energy‐autocorrelation function which contribute to the field‐parallel enhancement of heat conduction in strongly coupled plasmas. The investigation is based on first‐principle molecular dynamics simulations. (© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Equation of State of Nickel in WDM Region
Authors: Lomonosov I.V. , Gryaznov V.K. 
Published: April 2016

AbstractResults of theoretical calculations and experimental measurements of the equation of state (EOS) in the region of warm dense matter (WDM) are discussed and applied to nickel. The thermodynamic properties of nickel and its phase diagram are calculated with the use of multi‐phase EOS model. Theoretical calculations of thermodynamic properties of the solid, liquid, and plasma phases, and of the critical point, are compared with results of experiments. The analysis deals with thermodynamic properties of solid nickel at T = 0 and 298 K from different band–structure theories, static compression experiments in diamond anvil cells, and the information obtained in shock‐wave experiments. Thermodynamic data in the liquid and plasma states, resulting from traditional thermophysical measurements, ”exploding wire” experiments, and evaluations of the critical point are presented. Numerous shock‐wave experiments for nickel have been done to measure shock adiabats of crystal and porous samples and release isentropes. These data are analyzed in a self‐consistent manner together with all other available data at high pressure. (© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A native plant competitor mediates the impact of above‐ and belowground damage on an invasive tree
Authors: Carrillo Juli , Siemann Evan 
Published: April 2016

AbstractPlant competition may mediate the impacts of herbivory on invasive plant species through effects on plant growth and defense. This may predictably depend on whether herbivory occurs above or below ground and on relative plant competitive ability. We simulated the potential impact of above‐ or belowground damage by biocontrol agents on the growth of a woody invader (Chinese tallow tree, Triadica sebifera) through artificial herbivory, with or without competition with a native grass, little bluestem (Schizachyrium scoparium). We measured two defense responses of Triadica through quantifying constitutive and induced extrafloral nectar production and tolerance of above‐ and belowground damage (root and shoot biomass regrowth). We examined genetic variation in plant growth and defense across native (China) and invasive (United States) Triadica populations. Without competition, aboveground damage had a greater impact than belowground damage on Triadica performance, whereas with competition and above‐ and belowground damage impacted Triadica similarly. Whole plant tolerance to damage below ground was negatively associated with tolerance to grass competitors indicating tradeoffs in the ability to tolerate herbivory vs. compete. Competition reduced investment in defensive extrafloral nectar (EFN) production. Aboveground damage inhibited rather than induced EFN production while belowground plant damage did not impact aboveground nectar production. We found some support for the evolution of increased competitive ability hypothesis for invasive plants as United States plants were larger than native China plants and were more plastic in their response to biotic stressors than China plants (they altered their root to shoot ratios dependent on herbivory and competition treatments). Our results indicate that habitat type and the presence of competitors may be a larger determinant of herbivory impact than feeding mode and suggest that integrated pest management strategies including competitive dynamics of recipient communities should be incorporated into biological control agent evaluation at earlier stages.
Landscape‐scale ecohydrological mapping demonstrating how flood inundation water quality types relate to floodplain vegetation communities
Authors: Keizer F. M. , Schot P. P. , Okruszko T. , Wassen M. J. 
Published: April 2016

AbstractLandscape‐scale ecohydrological mapping is commonly restrained to one‐dimensional ecohydrological transect studies or two‐dimensional vegetation distributions lacking adequate spatial coverage of explanatory hydrological data. The objective of this paper is to construct a two‐dimensional (semi‐3D) landscape‐scale ecohydrological map based on vegetation distribution maps and detailed spatial, multi‐year, floodplain inundation water quality data. The dataset comes from the near‐natural Biebrza floodplain mire in Poland encompassing 658 inundation water quality analyses over the period 2002–2012, covering 17 different vegetation communities of freshwater marshes and rich fens. The data represent the main hydrological gradients from valley edge to river encompassing groundwater seepage, local stagnant precipitation influences and river flooding and drainage. We used chi‐squared Haberman residuals analysis to correlate communities to inundation water quality types, resembling river water and three different types of groundwater. Out of 17 communities, six showed a preference for river water, three showed a preference for clean groundwater, four for diluted groundwater and one for polluted groundwater. For three communities, no significant preference was found. Spatial patterns in vegetation and attributed water quality preference can be linked to three dominant hydrological processes at the landscape scale, i.e. discharge of clean and polluted groundwater near the valley edges, dilution of exfiltrated groundwater with local snowmelt and precipitation water and flooding with river water along the river. The ecohydrological relations are depicted in two‐dimensional maps and a semi‐3D diagram with typical cross sections. Copyright © 2016 John Wiley & Sons, Ltd.
Plasma calcidiol, calcitriol, and parathyroid hormone and risk of new onset heart failure in a population‐based cohort study
Authors: Meems Laura M. G. , Brouwers Frank P. , Joosten Michel M. , Lambers Heerspink Hiddo J. , de Zeeuw Dick , Bakker Stephan J. L. , Gansevoort Ron T. , van Gilst Wiek H. , van der Harst Pim , de Boer Rudolf A. 
Published: April 2016

AbstractBackgroundHeart failure (HF) is a major problem in the Western world, with increasing prevalence and incidence. Because HF cannot be cured, prevention of HF is of utter importance. Calcidiol, calcitriol, and parathyroid hormone (PTH) have been identified as risk factors for cardiovascular disease. However, their association with new onset HF remains to be established. We investigated whether calcidiol, calcitriol, and PTH could be used to identify those subjects at risk for new onset HF, and if they had additive predictive value over established risk predictors like N‐terminal‐pro Brain‐type natriuretic peptide and highly sensitive Troponin‐T.Methods and resultsWe examined 7470 HF‐free participants in Prevention of Renal and Vascular End‐stage Disease, a community‐based cohort study in Groningen, the Netherlands (latitude 53°N, mean age: 49 years, 48% male). During follow‐up time of 12.6 years (interquartile range: 12.3–12.9), 281 participants (4%) developed HF: 181 (66%) HF with reduced and 94 (34%) HF with preserved ejection fraction (HFrEF [left ventricular ejection fraction ≤ 40%], and HFpEF [left ventricular ejection fraction ≥ 50%], respectively). Mean (±SD) of calcidiol was 58 (±24) nmol/L, mean calcitriol 145 (±48) pmol/L, and median (interquartile range) PTH was 3.7 (3.0–4.6) pmol/L. Calcidiol levels were univariately associated with new onset HF [hazard ratio (HR) 0.82 (95% CI 0.69–0.96)], but calcitriol levels were not [HR 0.85 (95% CI 0.71–1.03)]. PTH levels kept their predictive value after adjustment for age, sex, and day of blood withdrawal (HR 1.26 [95% CI 1.04–1.53]). However, in our full model this association was lost [HR 1.10 (95% CI 0.92–1.32)]. Calcidiol, calcitriol, and PTH could not differentiate between new onset HFrEF or HFpEF.ConclusionsAfter adjustment for confounding factors, a single measurement of plasma calcidiol, calcitriol, or PTH was not associated with risk of developing HF. Screening for these markers to identify subjects at risk for new onset HF cannot be advocated.
Zinc‐Catalyzed Multicomponent Reactions: Easy Access to Furyl‐Substituted Cyclopropane and 1,2‐Dioxolane Derivatives
Authors: Mata Sergio , González Jesús , Vicente Rubén , López Luis A. 
Published: April 2016

AbstractA convenient synthesis of cyclopropyl‐substituted furan derivatives by a zinc‐catalyzed three‐component coupling of 1,3‐dicarbonylic compounds, 2‐alkynals and alkenes is reported. A sequence consisting of an initial Knoevenagel condensation, cyclization, and a final cyclopropanation reaction would account for the formation of the final products. In most cases, this multicomponent process proceeds in good yield under mild reaction conditions and in the presence of a low catalyst loading. The efficient formation of 1,2‐dioxolane derivatives by the zinc‐promoted aerobic oxidation of some cyclopropane derivatives is also reported. The 1,2‐dioxolane derivatives are also available by a four‐component reaction.
Role of MicroRNA 126 in screening, diagnosis, and prognosis of diabetic patients in Egypt
Authors: Rezk Noha A. , Sabbah Norhan A. , Saad Mohamed S.S. 
Published: April 2016

AbstractMicroRNAs (miRNAs), family of non‐coding small RNAs, play a vital role in the regulation of blood glucose level. We aimed to investigate the relation of serum miRNA‐126 expression with impaired glucose tolerance as well as type 2 diabetes mellitus (T2DM) patients with and without complications. One hundred healthy controls, eighty‐six patients with IGT, and one hundred patients with T2DM were recruited in this study. Serum miRNA‐126 expression was assessed by quantitative real‐time polymerase chain reaction. We found a significant decrease of serum miRNA‐126 expression between IGT patients as well as diabetic patients when both compared with controls and between diabetic patients compared to IGT patients. A significant decrease of serum miRNA‐126 expression was detected in diabetic patients with complications compared to those without evident complications especially those with diabetic macrovascular complications and diabetic retinopathy. Serum microRNA‐126 expression could be a good marker for diagnosis of IGT and T2DM as well as for monitoring the outcomes of such disease. © 2016 IUBMB Life, 68(6):452–458, 2016