bluuebunny/crossref_metadata_2025_split huggingface dataset:
Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L.
Authors: Végh Krisztina , Riethmüller Eszter , Tóth Anita , Alberti Ágnes , Béni Szabolcs , Balla József , Kéry Ágnes 
Published: June 2016

AbstractFeverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraine, headache and rheumatoid arthritis and possesses numerous pharmacological activities. An ultra‐high‐performance supercritical fluid chromatographic method (UHPSFC) was developed and validated in accordance with the International Conference on Harmonization guidelines in order to determine the camphor content of the volatile oil, which was accurate, precise, robust and selective. The method was validated for specificity, accuracy (100.2%), repeatability and intermediate precision, linearity (r2 > 0.999), limit of detection (2.055 μg/mL), limit of quantification (6.228 μg/mL) and robustness. The common range of accuracy and linearity was between 0.125 and 1.000 mg/mL. Steam distillation was carried out in order to study the essential oil yield of three different T. parthenium L. samples originating from Hungarian medicinal herb collections. The camphor content of the essential oils from the aerial parts of feverfew samples from different origin was compared. Although the composition of the essential oil is well reported, a validated quantitative UHPSFC method for the determination of the constituents is presented herein for the first time.
Finding the right fit: the search and selection process for direct assessment program enrollees
Authors: Morrison Cali M.K. 
Published: June 2016

BackgroundCoupling the new majority of learners being 22 or older with the dawning of new alternative programs such as direct assessment competency‐based programs this study serves two purposes—to test a model for researching college choice of competency‐based education (CBE) students and investigate how learners, like participant one mentioned above, who ultimately enroll in a direct assessment competency‐based program, search for and choose that program.MethodThis qualitative study utilized interviews to investigate how learners, who recently enrolled in direct assessment CBE programs, undertook the college choice process.ResultsInitial results found that 80% of participants (N = 5) did not complete a formal search process and chose to enroll based on information from a trusted source—namely their employers and in one case, the Washington Post. The flexibility and the potential for cost savings, both through credit for prior learning and the ability to move quickly, were key enrollment catalysts.ConclusionThe implications of this study are important for institutions developing competency‐based education programs—adult learners may not be actively looking for a program, the program has to find them through a trusted source and appeal to their wallet and career aspirations with flexible programs that treat them like the professionals they are.
A rare type of congenital Sturge‐Weber Syndrome: presenting with history of perinatal asphyxia
Authors: Ejike Obuoha , Odume Calistus , Ekwochi Uchenna , Ndu Ikenna , Imanyikwa Ugochukwu 
Published: June 2016

Key Clinical MessageThe presentation of a newborn with perinatal asphyxia and poor developmental milestones in a resource‐poor setting. Many a times, obscured, unsuspected, and uncommon etiologies compound well‐known causes of failure to thrive; in this case a rare finding of Type III Sturge‐Weber Syndrome was revealed by Brain CT scanning.
Thrombotic thrombocytopenic purpura presenting as acute coronary syndrome
Authors: Mouabbi Jason Aboudi , Zein Rami , Kafri Zyad , Al‐Katib Ayad , Hadid Tarik 
Published: June 2016

Key Clinical MessageIn patients presenting with thrombotic thrombocytopenia purpura and non‐ST elevation myocardial infarction, prompt initiation of plasma exchange takes precedence over other invasive diagnostic procedures for coronary artery disease. Such procedures should be delayed until clinical condition and laboratory parameters have been stabilized.
Conformation‐Controlled Diplatinum(II)–Ferrocene Dyads to Achieve Long‐Lived Charge‐Separated States
Authors: Wang Ge‐Xia , Feng Ke , Crossley Maxwell J. , Xing Ling‐Bao , Xiao Hong‐Yan , Li Wen , Tung Chen‐Ho , Wu Li‐Zhu 
Published: June 2016

AbstractSquare‐planar polypyridyl platinum(II) complexes possess a rich range of structural and spectroscopic properties that are ideal for designing artificial photosynthetic centers. Taking advantage of the directionality in the charge‐transfer excitation from the metal to the polypyridyl ligand, we describe here diplatinum(II)–ferrocene dyads, open‐butterfly‐like dyad 1 and closed‐butterfly‐like dyad 2, which were designed to understand the conformation and orientation effects to prolong the lifetime of charge‐separated state. In contrast to the open‐butterfly‐like dyad 1, the closed‐butterfly‐like dyad 2 shows three‐times long lifetime of charge separated state upon photoexcitation, demonstrating that the orientation in the rigid structure of dyad 2 is a very important issue to achieve long‐lived charge separated state.
A Sustainable, Semi‐Continuous Flow Synthesis of Hydantoins
Authors: Vukelić Stella , Koksch Beate , Seeberger Peter H. , Gilmore Kerry 
Published: June 2016

AbstractHydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps and often use reagents that are not commercially available or sustainable. Herein, an efficient process is described for accessing hydantoins starting from commercially available amines using consecutive gas–liquid transformations (oxygen, carbon dioxide). This semi‐continuous process produced ten benzylic/aliphatic hydantoins in good overall yields (52–84 %).
Room‐Temperature Gold‐Catalysed Arylation of Heteroarenes: Complementarity to Palladium Catalysis
Authors: Cresswell Alexander J. , Lloyd‐Jones Guy C. 
Published: June 2016

AbstractTailoring of the pre‐catalyst, the oxidant and the arylsilane enables the first room‐temperature, gold‐catalysed, innate C−H arylation of heteroarenes. Regioselectivity is consistently high and, in some cases, distinct from that reported with palladium catalysis. Tolerance to halides and boronic esters, in both the heteroarene and silane partners, provides orthogonality to Suzuki–Miyaura coupling.
ChemInform Abstract: The Crystal Structures of Ni3+xSn4Zn and Ni6+xSn8Zn and Their Structural Relations to Ni3+xSn4, NiSn and Ni5‐δZnSn4.
Authors: Schmetterer Clemens , Effenberger Herta Silvia , Rajamohan Divakar , Flandorfer Hans 
Published: June 2016

AbstractTwo new compounds, Ni3+xSn4Zn (x≈1.35, monoclinic, space group I2/m, Z = 2, single crystal XRD) and Ni6+xSn8Zn (x≈1.35, monoclinic, space group C2/m, Z = 2) are prepared by solid state reaction of the elements (Al2O3 crucible in evacuated quartz tubes, 1453 K).
ChemInform Abstract: Na2Hg3M2S8 (M: Si, Ge, and Sn): New Infrared Nonlinear Optical Materials with Strong Second Harmonic Generation Effects and High Laser‐Damage Thresholds.
Authors: Wu Kui , Yang Zhihua , Pan Shilie 
Published: June 2016

AbstractThe new title compounds are prepared from mixtures of Na, HgS, M (M: Si, Ge, Sn), and excess sulfur (600—700 °C, 60 h, 80% yield for Na2Hg3Si2S8).
ChemInform Abstract: Flower‐Like Cu2In2ZnS5 Nanosheets: A Novel Promising Photoelectrode for Water Splitting.
Authors: Hong Tiantian , Liu Zhifeng , Zhang Jing , Li Guangmin , Liu Junqi , Zhang Xueqi , Lin Shaohua 
Published: June 2016

AbstractA flower‐like Cu2In2ZnS5 structure composed of nanosheets on an indium tin oxide (ITO) substrate is hydrothermally synthesized from a mixture of CuCl, InCl4, Zn(OAc)2, and thioacetamide in EtOH together with the ITO substrate (autoclave, 200 °C, 1 h).
ChemInform Abstract: Chiral Squaramide Catalyzed Synthesis of C4 Substituted Chiral Pyrazol‐3‐ol Derivatives via a Facile Asymmetric Michael Addition of 3‐Methyl‐2‐pyrazolin‐5‐one to β‐Nitrostyrenes.
Authors: Rao Kadiyala Srinivasa , Ramesh Pambala , Trivedi Rajiv , Kantam M. Lakshmi 
Published: June 2016

AbstractA series of different chiral squaramide catalysts are screened for the enantioselective Michael addition of pyrazolinones (I) and (IV) to nitrostyrenes.
ChemInform Abstract: Organophotocatalytic Synthesis of Phosphoramidates.
Authors: Meazza Marta , Kowalczuk Agnieszka , Shirley Luke , Yang Jung Woon , Guo Hao , Rios Ramon 
Published: June 2016

AbstractDehydrogenative cross‐coupling reactions between phosphites and amines are performed using organic dyes and visible light, thus providing a sustainable and green protocol for preparation of phosphoramidates.
ChemInform Abstract: An Unexpected C—C Bond Cleavage of Acetophenones: Synthesis of Bis(heteroaryl)arylmethanes and Triarylmethanes via SeO2/Lanthanide Chloride Catalyzed Friedel—Crafts Arylation.
Authors: Kumar G. Santosh , Kumar A. Sanjeeva , Swetha A. , Babu B. Madhu , Meshram H. M. 
Published: June 2016

AbstractThe catalyst is recyclable.
ChemInform Abstract: CO2 Conversion into Esters by Fluoride‐Mediated Carboxylation of Organosilanes and Halide Derivatives.
Authors: Frogneux Xavier , von Wolff Niklas , Thuery Pierre , Lefevre Guillaume , Cantat Thibault 
Published: June 2016

AbstractAn optimized method is developed which allows the preparation of heteroaromatic esters under metal‐free conditions.
ChemInform Abstract: Ruthenium‐Catalyzed Multicomponent Reactions: Access to α‐Silyl‐β‐Hydroxy Vinylsilanes, Stereodefined 1,3‐Dienes, and Cyclohexenes.
Authors: Trost Barry M. , Koester Dennis C. , Sharif Ehesan U. 
Published: June 2016

AbstractA broad spectrum of linear unsaturated silanes can be prepared from the same educts (I), (II) and different aliphatic or aromatic aldehydes in the presence of a ruthenium catalyst via variation of the reaction conditions.
ChemInform Abstract: Highly Efficient Biphasic Ozonolysis of Alkenes Using a High‐Throughput Film‐Shear Flow Reactor.
Authors: Kendall Alexander J. , Barry Justin T. , Seidenkranz Daniel T. , Ryerson Ajay , Hiatt Colin , Salazar Chase A. , Bryant Dillon J. , Tyler David R. 
Published: June 2016

AbstractA new method for flow ozonolysis using a film‐shear reactor is developed.
ChemInform Abstract: Palladium‐Catalyzed Carbonylative α‐Arylation of tert‐Butyl Cyanoacetate with (Hetero)aryl Bromides.
Authors: Jensen Mikkel T. , Juhl Martin , Nielsen Dennis U. , Jacobsen Mikkel F. , Lindhardt Anders T. , Skrydstrup Troels 
Published: June 2016

AbstractA mild method is developed for the synthesis of a variety of β‐ketonitriles from aryl‐, hetaryl‐, and cinnamyl bromides, tert‐butyl 2‐cyanoacetate, and carbon monoxide using a two chamber system.
ChemInform Abstract: TBHP‐Promoted and Iodide‐Catalyzed Synthesis of Anhydrides via Cross Dehydrogenative Coupling (CDC) of Aldehydes.
Authors: Singha Raju , Ghosh Munmun , Nuree Yasin , Ray Jayanta K. 
Published: June 2016

AbstractThe newly developed method can also be successfully applied for the synthesis of amides.
ChemInform Abstract: Highly Energetic, Low Sensitivity Aromatic Peroxy Acids.
Authors: Gamage Nipuni‐Dhanesha H. , Stiasny Benedikt , Stierstorfer Joerg , Martin Philip D. , Klapoetke Thomas M. , Winter Charles H. 
Published: June 2016

AbstractAcids (II) and (IV) are prepared as shown.
ChemInform Abstract: Pummerer Reaction of Sulfoxides in Acetic Anhydride Catalyzed by Al‐MCM‐41.
Authors: Ito Suguru , Kubota Yoshihiro , Asami Masatoshi 
Published: June 2016

AbstractAl‐MCM‐41 is found to be a useful catalyst for both inter‐ and intramolecular Pummerer reactions of sulfoxides.
ChemInform Abstract: Chemoselective Claisen—Schmidt Bis‐substitutional Condensation Catalyzed by an Alkoxy‐Bridged Dinuclear Ti(IV) Cluster.
Authors: Wu Yufei , Hou Jie , Liu Yuliang , Zhang Mingfu , Tung Chen‐Ho , Wang Yifeng 
Published: June 2016

AbstractAn efficient approach to a series of α,α‐bis‐substituted alkanone structures becomes possible in the presence of DTC (mechanism of the catalytic process).
ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Kinetic Resolution of Indolines Based on a Self‐Redox Reaction.
Authors: Saito Kodai , Akiyama Takahiko 
Published: June 2016

AbstractThe oxidative kinetic resolution involves an asymmetric intermolecular hydride transfer from indoline to an iminium intermediate generated from indoline and the salicylaldehyde reagent.
ChemInform Abstract: Simple and Mild Synthesis of Indoles via Hydroamination Reaction Catalyzed by NHC‐Gold Complexes: Looking for Optimized Conditions.
Authors: Michalska Malina , Grela Karol 
Published: June 2016

Abstract2‐Alkynylanilines are converted into the corresponding indoles using AuCl(IPr) complex as catalyst with catalyst loadings as low as 0.25 mol% for many of the substrates.
ChemInform Abstract: Highly Regioselective Synthesis of Pyrazole Derivatives Using a 1,3‐Dipolar Cycloaddition Approach.
Authors: Alizadeh Abdolali , Moafi Leila , Zhu Long‐Guan 
Published: June 2016

Abstract3‐Formylchromones and aryloyl chloride phenylhydrazones react regioselectively under basic conditions to give the 1‐phenyl‐3‐aryl‐5‐(2‐hydroxybenzoyl)pyrazoles via an intermediary formed nitrile imine.
ChemInform Abstract: Generation of Oxazolidine‐2,4‐diones Bearing Sulfur‐Substituted Quaternary Carbon Atoms by Oxothiolation/Cyclization of Ynamides.
Authors: Huang Hai , Fan Junzhen , He Guangke , Yang Zhimin , Jin Xiaodong , Liu Qi , Zhu Hongjun 
Published: June 2016

AbstractA novel method for the metal‐free oxothiolation of ynamides to construct oxazolidine‐2,4‐diones bearing sulfur‐substituted quaternary carbon atoms is developed.
ChemInform Abstract: DBU and DBU‐Derived Ionic Liquid Synergistic Catalysts for the Conversion of Carbon Dioxide/Carbon Disulfide to 3‐Aryl‐2‐oxazolidinones/[1,3]Dithiolan‐2‐ylidenephenylamine.
Authors: Wang Binshen , Luo Zhoujie , Elageed Elnazeer H. M. , Wu Shi , Zhang Yongya , Wu Xiaopei , Xia Fei , Zhang Guirong , Gao Guohua 
Published: June 2016

AbstractThe title compounds are prepared by conversion of CO2/CS2, epoxides, and amines under solvent‐ and metal‐free conditions.
ChemInform Abstract: Triacetic Acid Lactone as a Common Intermediate for the Synthesis of 4‐Hydroxy‐2‐pyridones and 4‐Amino‐2‐pyrones.
Authors: Kraus George A. , Wanninayake Umayangani K. , Bottoms Jashaun 
Published: June 2016

AbstractTriacetic acid lactones (I) and (IV) react with amines at room temperature to yield 4‐aminopyrans (VI).
ChemInform Abstract: Metal‐Free Oxidative Hydrophosphinylation of 1,7‐Enynes.
Authors: Zhu Yi‐Long , Wang De‐Cai , Jiang Bo , Hao Wen‐Juan , Wei Ping , Wang Ai‐Fang , Qiu Jiang‐Kai , Tu Shu‐Jiang 
Published: June 2016

AbstractA method for construction of polyfunctionalized dihydroquinolines is developed.
ChemInform Abstract: Synthesis of Two ′Heteroaromatic Rings of the Future′ for Applications in Medicinal Chemistry.
Authors: Silva P. E. Jr. , Rezende L. C. D. , Possamai Gimenes Julia , Goncalves Maltarollo Vinicius , Dale James , Trossini G. H. G. , Emery F. S. , Ganesan A. 
Published: June 2016

AbstractA short and inexpensive route to pyrazolopyridinol (II) and to the previously unknown naphthyridinol (X) is reported.
ChemInform Abstract: Hydrophobically Directed, Catalyst‐Free, Multi‐Component Synthesis of Functionalized 3,4‐Dihydroquinazolin‐2(1H)‐ones.
Authors: Ramana Daggupati V. , Vinayak B. , Dileepkumar V. , Murty U. S. N. , Chowhan L. Raju , Chandrasekharam M. 
Published: June 2016

AbstractA wide range of the title quinazolinones (44 examples) is prepared by environmentally benign one‐pot, three‐component reaction of o‐formyl carbamate, a primary amine, and indole or naphthol as nucleophiles involving a Mannich type reaction and subsequent intramolecular cyclization.
ChemInform Abstract: Simple and Efficient Copper‐Catalyzed Synthesis of Symmetrical Diaryl Selenides from Triarylbismuthanes and Selenium under Aerobic Conditions.
Authors: Matsumura Mio , Kumagai Hanae , Murata Yuki , Kakusawa Naoki , Yasuike Shuji 
Published: June 2016

AbstractAn atom‐economic, simple Cu‐catalyzed procedure for preparation of biologically and pharmaceutically interesting symmetrical diaryl selenides is developed.
ChemInform Abstract: The Total Synthesis of (.+‐.)‐Naupliolide: A Tetracyclic Sesquiterpene Lactone.
Authors: Abe Hideki , Morishita Tomoyuki , Yoshie Toshihiro , Long Kerya , Kobayashi Toyoharu , Ito Hisanaka 
Published: June 2016

AbstractThe first total synthesis of racemic naupliolide is accomplished from a known cyclic acetal in a total of 18 steps and includes a Simmons‐Smith cyclopropanation of an allylic alcohol, diastereoselective cleavage of a benzylidene acetal group, radical cyclization of an aldehyde with a cyclopropane ring, and construction of an eight‐membered ring by ring‐closing metathesis.
ChemInform Abstract: Haebaruol, a 9,11‐Secosteroid Isolated from the Soft Coral Clavularia sp.
Authors: Inuzuka Toshiyasu , Kawazoe Yoshinori , Kobayashi Satomi , Matsumoto Rie , Yabe Jouto , Ohmura Sachikazu , Uemura Daisuke 
Published: June 2016

Abstractisolation and structure determination of the novel cytotoxic secosteroid (I)
ChemInform Abstract: KOtBu‐Mediated Aromatic O‐Glycosylation of 1,2‐Anhydrosugar and Aryl Boronic Acid.
Authors: Liu Chen‐Fu , Xiong De‐Cai , Ye Xin‐Shan 
Published: June 2016

AbstractA new useful method for the synthesis of phenolic glycosides by the reaction of 1,2‐anhydrosugars with aryl boronic acids is reported.
ChemInform Abstract: Vinmajorines C—E, Monoterpenoid Indole Alkaloids from Vinca major.
Authors: Zhang Zhi‐Jun , Du Ru‐Nan , He Juan , Wu Xing‐De , Li Yan , Li Rong‐Tao , Zhao Qin‐Shi 
Published: June 2016

AbstractVinmajorines C (Ia), D (Ib) and E (Ic) are isolated from the whole plants of Vinca major along with 18 known analogues.
ChemInform Abstract: Structural Characterization of Dimeric Indole Alkaloids from Psychotria brachybotrya by NMR Spectroscopy and Theoretical Calculations.
Authors: Ribeiro Marcos A. dos S. , Gomes Carla M. B. , Formagio Anelise S. N. , Pereira Zefa V. , Melo Ulisses Z. , Basso Ernani A. , da Costa Willian F. , Baldoqui Debora C. , Sarragiotto Maria H. 
Published: June 2016

AbstractChemical study of Psychotria brachybotrya leads to the isolation of a new dimeric tryptamine‐related alkaloid named brachybotryne (I), its N‐oxide derivative (II), and a known compound identified as bufotenine.
ChemInform Abstract: Copper‐Catalyzed Direct Cross‐Coupling of Compounds Containing Activated C—H/Heteroatom—H Bonds with N‐Tosylhydrazones
Authors: Jadhav Amol P. , Ray Devalina , Rao V. U. Bhaskara , Singh Ravi P. 
Published: June 2016

AbstractReview: [42 refs.
Vorkalkulation chemischer Anlagen
Authors: Rähse Wilfried 
Published: June 2016

AbstractDie wirtschaftliche Analyse von Herstellprozessen erlaubt eine Standortbestimmung und die Priorisierung von Entwicklungsprojekten. Zunächst erfolgt eine Vorkalkulation zur Abschätzung der Investitionskosten. Kalkulationsbasis ist ein vollständiges Verfahrensfließbild mit Massen‐ und Energiebilanzen zur Auslegung der Verfahrensstufen, ausgeführt im Standardwerkstoff 1.4571. Andere Werkstoffe lassen sich über angegebene Faktoren anpassen, andere Größen und Kapazitäten über Degressionsexponenten. Die Vorkalkulation wird beispielhaft erläutert. Investitionskosten bilden die Grundlage zur anschließenden Ermittlung der Herstellkosten.
Impact of fine solids on mined athabasca oil sands extraction II. Effect of fine solids with different surface wettability on bitumen recovery
Authors: Zhou Zoe A. , Li Haihong , Chow Ross , Adeyinka Olusola B. , Xu Zhenghe , Masliyah Jacob 
Published: June 2016

ABSTRACTThe effect of solids wettability on bitumen extraction recovery and froth quality was examined by adding fine solids (< 5 and < 40 μm silica, or < 5 μm kaolinite clays) and surfactants (dodecylamine) to the oil sands slurry. Oil sands extraction tests were run using a 1‐L Denver flotation cell at 50 °C. The results show that solids wettability plays a significant role in bitumen extraction recovery and froth quality. Adding fine solids to the oil sands slurry decreased bitumen recovery, and increased the amount of solids and water in the bitumen froth. The addition of finer solids (< 5 μm) into the oil sands slurry resulted in more solids and water in the bitumen froth than the addition of coarser solids (< 40 μm). Compared to hydrophilic solids, hydrophobized fine solids due to amine addition led to more fine solids being recovered to the bitumen froth. However, recovery of hydrophobized fine solids (resulting from amine adsorption) increased with smaller particle sizes, which is contrary to the trend in single mineral flotation where hydrophobized solids recovery increased with increasing particle sizes (for the size faction of < 44 μm).
Impaired constitutive and regenerative neurogenesis in adult hyperglycemic zebrafish
Authors: Dorsemans Anne‐Claire , Soulé Stéphanie , Weger Meltem , Bourdon Emmanuel , Lefebvre d'Hellencourt Christian , Meilhac Olivier , Diotel Nicolas 
Published: June 2016

AbstractA growing body of evidence supports hyperglycemia as a putative contributor to several brain dysfunctions observed in diabetes patients, such as impaired memory capacity, neural plasticity, and neurogenic processes. Thanks to the persistence of radial glial cells acting as neural stem cells, the brain of the adult zebrafish constitutes a relevant model to investigate constitutive and injury‐induced neurogenesis in adult vertebrates. However, there is limited understanding of the impact of hyperglycemia on brain dysfunction in the zebrafish model. This work aimed at exploring the impact of acute and chronic hyperglycemia on brain homeostasis and neurogenesis. Acute hyperglycemia was shown to promote gene expression of proinflammatory cytokines (il1β, il6, il8, and tnfα) in the brain and chronic hyperglycemia to impair expression of genes involved in the establishment of the blood–brain barrier (claudin 5a, zona occludens 1a and b). Chronic hyperglycemia also decreased brain cell proliferation in most neurogenic niches throughout the forebrain and the midbrain. By using a stab wound telencephalic injury model, the impact of hyperglycemia on brain repair mechanisms was investigated. Whereas the initial step of parenchymal cell proliferation was not affected by acute hyperglycemia, later proliferation of neural progenitors was significantly decreased by chronic hyperglycemia in the injured brain of fish. Taken together, these data offer new evidence highlighting the evolutionary conserved adverse effects of hyperglycemia on neurogenesis and brain healing in zebrafish. In addition, our study reinforces the utility of zebrafish as a robust model for studying the effects of metabolic disorders on the central nervous system. J. Comp. Neurol. 525:442–458, 2017. © 2016 Wiley Periodicals, Inc.