bluuebunny/crossref_metadata_2025_split huggingface dataset:
Heat shock proteins (HSPs) in non-alcoholic fatty liver disease (NAFLD): from molecular mechanisms to therapeutic avenues
Authors: Nie Zhenwang , Xiao Congshu , Wang Yingzi , Li Rongkuan , Zhao Fangcheng 
Published: October 2024

AbstractNon-alcoholic fatty liver disease (NAFLD), a spectrum of liver conditions characterized by fat accumulation without excessive alcohol consumption, represents a significant global health burden. The intricate molecular landscape underlying NAFLD pathogenesis involves lipid handling, inflammation, oxidative stress, and mitochondrial dysfunction, with endoplasmic reticulum (ER) stress emerging as a key contributor. ER stress triggers the unfolded protein response (UPR), impacting hepatic steatosis in NAFLD and contributing to inflammation, fibrosis, and progression to NASH and eventually hepatocellular carcinoma (HCC). Heat shock proteins (HSPs), including small HSPs such as HSP20 and HSP27, HSP60, HSP70, GRP78, and HSP90, are integral to cellular stress responses. They aid in protein folding, prevent aggregation, and facilitate degradation, thus mitigating cellular damage under stress conditions. In NAFLD, aberrant HSP expression and function contribute to disease pathogenesis. Understanding the specific roles of HSP subtypes in NAFLD offers insights into potential therapeutic interventions. This review discusses the involvement of HSPs in NAFLD pathophysiology and highlights their therapeutic potential. By elucidating the molecular mechanisms underlying HSP-mediated protection in NAFLD, this article aims to pave the way for the development of targeted therapies for this prevalent liver disorder.
Review of the current ongoing clinical trials exploring the possible anti-anxiety effects of cannabidiol
Authors: Bhuller Rhenu , Schlage Walter K. , Hoeng Julia 
Published: October 2024

Abstract
Background
Anxiety disorders (ADs) are a complex group of mental disorders and majorly contribute to the global health-related burden. Symptoms and clinical management differ widely depending on the specific diagnosis. There is a need for new, more effective pharmacological treatments for these patients as many patients do not respond to treatment and treatment is not available for several types of AD. The increased interest in the potential effects of cannabidiol (CBD) on symptoms of AD has led to several preclinical and clinical studies that suggest that CBD may be effective in some patients with AD. However, it remains unclear whether and how CBD can be used in the clinical management of ADs due to a lack of sufficiently robust clinical evidence.

Comparative evaluation
This narrative review provides a critical analysis of the current state of the art for ADs and summarizes six recently completed and 22 currently ongoing clinical trials investigating the effects of CBD on ADs or anxiety. The aim was to examine whether the ongoing trials are likely to provide the necessary solid evidence, or whether new studies with more robust design parameters can help to overcome the prevailing lack of solid clinical data for this CBD indication. Most of the trials reviewed are considered exploratory and do not focus on specific types of clinical anxiety or ADs as the primary condition studied. Participant numbers, CBD dose, treatment duration, and CBD formulation vary widely among the studies, and all but two are single-center studies.

Conclusion
For an effective clinical management of ADs using CBD, there is a need for sufficiently powered and appropriately designed clinical trials (RCT, multicenter, defined doses and exposure monitoring, robust primary outcomes) investigating the effect of CBD in specific ADs, such as social anxiety disorder and panic disorder, or in post-traumatic stress disorder.
Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next-generation sequencing data analysis
Authors: Vastrad Basavaraj , Vastrad Chanabasayya 
Published: October 2024

Abstract
Background
Endometriosis is a common cause of endometrial-type mucosa outside the uterine cavity with symptoms such as painful periods, chronic pelvic pain, pain with intercourse and infertility. However, the early diagnosis of endometriosis is still restricted. The purpose of this investigation is to identify and validate the key biomarkers of endometriosis.

Methods
Next-generation sequencing dataset GSE243039 was obtained from the Gene Expression Omnibus database, and differentially expressed genes (DEGs) between endometriosis and normal control samples were identified. After screening of DEGs, gene ontology (GO) and REACTOME pathway enrichment analyses were performed. Furthermore, a protein–protein interaction (PPI) network was constructed and modules were analyzed using the Human Integrated Protein–Protein Interaction rEference database and Cytoscape software, and hub genes were identified. Subsequently, a network between miRNAs and hub genes, and network between TFs and hub genes were constructed using the miRNet and NetworkAnalyst tool, and possible key miRNAs and TFs were predicted. Finally, receiver operating characteristic curve analysis was used to validate the hub genes.

Results
A total of 958 DEGs, including 479 upregulated genes and 479 downregulated genes, were screened between endometriosis and normal control samples. GO and REACTOME pathway enrichment analyses of the 958 DEGs showed that they were mainly involved in multicellular organismal process, developmental process, signaling by GPCR and muscle contraction. Further analysis of the PPI network and modules identified 10 hub genes, including vcam1, snca, prkcb, adrb2, foxq1, mdfi, actbl2, prkd1, dapk1 and actc1. Possible target miRNAs, including hsa-mir-3143 and hsa-mir-2110, and target TFs, including tcf3 (transcription factor 3) and clock (clock circadian regulator), were predicted by constructing a miRNA-hub gene regulatory network and TF-hub gene regulatory network.

Conclusions
This investigation used bioinformatics techniques to explore the potential and novel biomarkers. These biomarkers might provide new ideas and methods for the early diagnosis, treatment and monitoring of endometriosis.
THE HIERARCHY OF VALUE ORIENTATIONS OF STUDENTS
Authors: Pavlova Ksenia N. 
Published: October 2024

The article is devoted to the study of the hierarchy of value orientations of students. The relevance of the study is due to the fact that in the modern world, the value orientations of young people are undergoing changes. The transformation of values, one way or another, can be influenced by political, economic events and internal processes. It is known that young people are the most sensitive to all changes. Therefore, it is important to consider the value orientations of student youth, since this category of people is the main engine of progress in our society.
Purpose. To consider the hierarchy of value orientations of students.
Research methods. The value questionnaire of Sh. Schwartz, R. Inglehart's method (modified by M.S. Yanitsky).
As a result of the research, the hierarchy of value orientations of students is analyzed at the level of normative ideals and individual priorities, as well as by value types (adaptation, socialization, individualization).
Pneumoparotid with imaging findings: A case report and review of literature
Authors: Kubota Wakako , Kyan-Onodera Makiko , Fujimoto Yasuomi , Sakuma Akihiro , Katada Ryuji , Sugiura Chihiro 
Published: October 2024

BACKGROUND
Pneumoparotid is a rare disease associated with retrograde airflow into the ductal system. There is no established treatment for this disease, which has no known complications. Mouth puffing and playing wind instruments are known to be the causes of this disease.
CASE SUMMARY
We managed a case, in which pneumoparotid suddenly recurred 4 months after surgery for purulent parotiditis. The patient did not report any obvious etiological factors, such as mouth puffing or playing a wind instrument. We reviewed 128 articles (from 1941 to 2023) that reported on a total of 166 patients with pneumoparotid, including the patient from the present case report, with imaging findings. This is the first reported case of pneumoparotid following surgery for purulent parotitis. The etiology in our case was classified as idiopathic.
CONCLUSION
Imaging findings could be sufficient for accurate pneumoparotid diagnoses and the exclusion of complications; computed tomography could be useful.
Potential of organometallic complexes in medicinal chemistry
Authors: Qader Sarbaz Mohammed , Azhin hamad mohammed  , Muhammed Akar Mahmood , Omer Rebaz Anwar , Abdulkareem Eman Ibraheem , Rashid Rzgar Faruq 
Published: October 2024

Abstract
Organometallic complexes, which include ligands such as carbon monoxide (CO), carbenes, alkyls, phenyls, p-bound alkynes, alkenes, cyclopentadienyls, and arenes, have been extensively utilized in fields like materials chemistry and catalysis. These complexes also offer opportunities for the development of new medications with unique modes of action. Specifically, we are interested in anticancer drugs that can enhance the effectiveness of platinum treatments, broaden their range of action, reduce adverse effects, and prevent resistance. The distinct physiochemical properties of organometallic complexes have made them valuable in homogeneous catalysis, including the production of lead compounds and therapeutic possibilities. Over the past 20 years, a small group of researchers worldwide has explored the medical applications of these compounds’ unique characteristics, such as their structural diversity, potential for ligand exchange, and redox and catalytic properties. The results have been remarkable, and it is anticipated that numerous other organometallic compounds will undergo clinical trials in the coming years in addition to those already underway. In this brief study, we outline the advantages that organometallic metal complexes have over coordination compounds and pure organic molecules.
Hybrid system for nitric oxide and hydrogen production
Authors: Selemir V. D. , Shirshin A. S. , Buranov S. N. , Valueva J. V. , Golovanov V. V. , Smirnov D. P. , Tyrzov V. N. 
Published: October 2024

The device for nitric oxide inhalation therapy TIANOX has been put into use in clinical practice. It produces NO in nonequilibrium plasma of a diffusive spark discharge in the air at atmospheric pressure. There is a tendency to use a therapeutic gas mixture with high NO concentration for inhalation in the developing medical treatment methods. Nitric oxide transition into active compounds such as nitric dioxide, peroxynitrite, and nitrotyrosine can lead to oxidative stress. The use of hydrogen as an antioxidant that decreases the levels of hydroxyl radicals and peroxynitrite can protect cells from oxidative damage. Positive effect of the nitric oxide mixture and hydrogen is shown in the experiments with animals.The aim of the article is to describe development and performance the first hybrid system producing nitric oxide and hydrogen that was created in Federal State Unitary Enterprise “Russian Federal Nuclear Center – All-Russian Research Institute of Experimental Physics”. The system is based on the plasmochemical generator Tianox and the hydrogen generator, which is based on the electrolyzer with a solid polymeric electrolyte. It is fitted with H2, NO, and NO2 monitor and provides a continuous monitoring of concentrations of these gases and helps ensure safety of medical procedures by disconnecting NO and H2 generators at the moment when the gas concentrations exceed maximum levels (H2max, NOmax, NO2max).Conclusion. This hybrid system for nitrogen and hydrogen production passed the first study in human successfully. The preclinical studies also demonstrated its efficacy and safety.
The Prevalence and Predictors of Workplace Violence Among Hospital Staff
Authors: Ghavami Vahid , Daghighbin Elahe , Fathi Mohammad , Kokabisaghi Fatemeh , Shabanikiya Hamidreza 
Published: October 2024

Background: Workplace violence has always been a serious chal-lenge in health care systems. It reduces employees’ satisfaction and productivity, and increases the potential for adverse medical events. This study aimed to determine the prevalence and predictors of workplace violence among hospital clinical staff.
Methods: This cross-sectional study was conducted on 140 hospital care staff including nurses and paramedics in 2022. The standard questionnaire of WHO on workplace violence in health sector was used to collect data. To describe the quantitative variables, the mean and standard deviations were utilized, and for analyzing the data, multiple logistic regression model was used. The analysis was performed using SPSS 26.
Results: The results showed that 47.9% of the participants ex-perienced verbal violence at least once in the past year, and 19.3% experienced sexual violence. Regarding the perpetrators of violence, except for physical violence, colleagues accounted for the highest. Most physical violence cases against the clinical staff were perpetrated by one of the patient’s family members. Gender, marital status, and years of work experience were determined as predictors of workplace violence. Married male employees with limited work experience were disproportionately at risk of workplace violence.
Conclusion: Hospital clinical staff were exposed to all kinds of violence, especially verbal violence. Training personnel on the management of workplace violence and enhancing their communication skills and determining the scope, and predictors of workplace violence can help healthcare managers reduce the violence and its complications.
A Questionnaire Based Study on Awareness of Sanitization of Tooth Brushes in Indian Population and Their Disinfection with an Oral Hygiene Aid Sterilizer: A Clinical and In-Vitro Study.
Authors: Patil Dr. Chitra Laxmikant , Ghodke Dr.Monali , Redkar Dr.Gaurav , Dedhia Dr.Maitri , Pal Dr.Poulomi , Jain Dr.Devi 
Published: October 2024

Abstract:
Oral diseases are a major public health concern, owing to their high prevalence and their relationship with systemic health. Oral health maintenance can only be accomplished with proper tooth brushing & tongue cleaning. Toothbrushes are kept in places which is a hub of contaminants. They should be correctly stored, disinfected and changed at regular intervals.
Aims: Our study focuses on awareness of disinfection of toothbrushes among general population and invention of a newer device that not only keeps the toothbrush moisture free but also germ free: Oral Hygiene Aid Sterilizer (OHA-S).
Methods and Material: A cross sectional questionnaire based study of sample size 100 was conducted in which samples were randomly selected and distributed with a questionnaire form. All the study participants were asked to brush their teeth with the tooth brush provided. After brushing, the contaminated bristles were disinfected in the newer device: OHA-S and were observed under phase contrast microscope.
Statistical analysis used: Randomized control trial
Results: Survey results showed that 61% of general population was unaware of sanitization of toothbrushes. The remaining being aware, almost 72% did not perform sanitization on daily basis. Also, there was a significant decrease in microbial flora of the bristles which were sanitized using OHA-S when observed under the phase contrast microscope
Conclusions: As majority of population failed at sanitizing oral hygiene aids daily, OHA-S was effective in not only making the oral hygiene aids moisture free but also in reducing the amount of microbial load which is the main causative factor for periodontal diseases .
Architectural Design Studio Works Exploring Archetype based on Ecological Sensibilities from Experiencing Najdi Architecture of At-Turaif town and Modern Riyadh
Authors: Yun SukHee , Yi Tae Yeual 
Published: October 2024

The numbness to human loss becomes ordinary. Indifference to human affairs seems normal after experiencing the global lockdown. Bringing up empathy becomes the most challenging task in architectural design studios after COVID pandemic. Examining otherness solidified after global pandemic would be a way to revive the empathy to engage more in architecture design studios. The physiological disparity between the modern and the vernacular environments narrows down with the revival of Najd architecture, Salmani architecture style and Diriyah Gate Project in Riyadh, KSA. The disparity is caused by intangible factors such as speed and density, but the revival focuses heavily on the tangible, formal expression. The architectural elements in the vernacular, Najd architecture, have different meanings and roles more than being a decorative motif. The feeble values of the vernacular undermined by touristic images are challenged by a series of radical design projects not to be generalized again by picturesque replicas of the past. Seeing the lost, the ecological sensibility of a community or collective will that embraced the harshest land with full respect, might not be visual but radically experiential like a serendipitous breeze in Riyadh. This paper introduces a series of studio works that challenged how to bring back the living structure in the harshest environment to daily lives through experimental and speculative design processes. It proposes how a community is called onto guard the environmental landscape again defying the visual interpretation of Najd architecture in the political landscape dominated by high fence walls.
Analysis of the impact of mechanisms of integration of university science into the regional innovation system on the spatial development of the Voronezh region
Authors: Golikova G. V. , Prityko E. A. , Makarova O. S. , Kazmin A. A. 
Published: October 2024

Relevance. University science is the basis for the progressive development of the regions of the Russian Federation, providing new knowledge and ideas, turning knowledge into technology and accelerated development of the cultural environment. The introduction of scientific research into the educational process is necessary and important conditions for maintaining the high professional level of teachers, the formation of professional competencies, and advanced training of future specialists. In the last few years, the main economic processes have demonstrated positive dynamics, which indicates the effectiveness of the implemented strategy of socio-economic development of the region, as well as an effective policy of spatial development of the territory are key factors in achieving a positive trend in the development of the region. Minister of Science and Higher Education V.N. Falkov in April 2024 He stated the need to transform the higher education system, focusing on specialized higher education based on an interdisciplinary approach that will more effectively integrate university science into regional spatial development and the national innovation system.The purpose of the study is to determine the mechanisms of integration of university science in the spatial development of the Voronezh region through the innovation system.Objectives: to analyze the impact of the mechanisms of integration of university science on the trends of spatial development; to analyze scientific and technological development; to formulate the main conclusions about university science as part of the socio-economic system of the territory.Methodology. The general scientific methods of logical analysis, method of desk research, method of systematization, descriptive method were used in the study. Results. The study revealed the key factors that contributed to the positive dynamics of the economy of the Voronezh region and considered the mechanisms of integration of university science into the regional innovation system.Conclusions. In the realities of scientific and technological development there is a need to improve the methods of integration of university science into the regional innovation system, and recommendations related to the optimization of spatial development of the Voronezh region in order to improve the quality and attractiveness of university science on the basis of innovative aspects functioning in the region have been proposed.
Management of scientific and technological regional development in the Volga Federal District: review of government programs
Authors: Gataullina A. A. , Zyabbarova A. A. 
Published: October 2024

Relevance. In light of the growing interest in the scientific and technological development of regions, setting goals for scientific and technological advancement at the national level, the issue of developing programs for the development of science and education leading to the technological sovereignty of the country becomes relevant.The purpose is to analyze the ongoing programs for scientific and technological development of the regions of the Volga Federal District, as well as individual indicators characterizing the dynamics of the scientific and educational sector of the constituent entities of the Russian Federation.Objectives: conduct an economic and statistical analysis of the main indicators characterizing the scientific and technological progress of the regions of the Volga Federal District; identify regions of the Volga Federal District in which state programs for scientific and technological development have been developed, and consider their features.Methodology. The study used methods of economic-statistical and comparative analysis.Results. A review of state programs for scientific and technological development shows that four pilot regions of the Volga Federal District (Nizhny Novgorod region, Republic of Tatarstan, Republic of Bashkortostan and Republic of Mordovia) have already developed corresponding programs, and two regions (Orenburg region and Perm Territory) are under development. The remaining regions either have state programs that indirectly indicate the development of scientific and technological potential, or they do not exist.Conclusions. Scientific and technological development programs represent an important document that defines strategic guidelines for the development of science, technology and higher education. Regions that have already developed state programs for scientific and technological development have a high scientific reserve and are located in the top positions in the National Rating of Scientific and Technological Development of Regions. Such regions show strong results in the scientific and educational sector, which contributes to improving the economic and social development of the region. A systematic analysis of these programs makes it possible to identify their impact on various aspects of social life, as well as determine the effectiveness of the measures taken and mechanisms for achieving the set goals. It is important to take into account the variety of approaches to the development and implementation of strategic programs, which should be aimed at the unique characteristics of the country’s regions, their bottlenecks and development prospects, taking into account an assessment of their potential.