bluuebunny/crossref_metadata_2025_split huggingface dataset:
Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse
Authors: Li Jie , Xia Wei , Su Xueting , Qin Xingliang , Chen Ying , Li Shaohua , Dong Jie , Ding Hongmei , Li Hui , Huang Aixue , Ge Xingfeng , Hou Lvbin , Wang Chaonan , Sun Leqiao , Bai Chenjun , Shen Xuelian , Fang Tao , Liu Yuanlin , Zhang Yi , Zhang Hongru , Zhang Hongwen , Shao Ningsheng 
Published: May 2016

AbstractIn recent years, p53 was identified to regulate the expression of many miRNAs and was also regulated by miRNAs. In this paper, we found that miR-138 showed a pronounced increase after p53 activation in human non-small cell lung cancer (NSCLC) cells, which is mediated by p53 binding sites in the promoter region of its host gene, but this did not happen with rat and mouse cells. More interestingly, we found that p53 could be also regulated by miR-138 in mouse and rat cells, but not in the human NSCLC cells. Our results suggest the existence of species-specific differences of the regulations of miRNA against its targets and the regulations of miRNA itself by other proteins.
Prevalence of colonic diverticulosis in mainland China from 2004 to 2014
Authors: Hong Wandong , Geng Wujun , Wang Chao , Dong Lemei , Pan Shuang , Yang Xinjing , Zippi Maddalena , Xu Chunfang , Zhou Mengtao , Pan Jingye 
Published: May 2016

AbstractThe aim of this study was to determine the prevalence of colonic diverticulosis in mainland China. Sixty two thousand and thirty-four colonoscopies performed between Jan 2004 and Dec 2014 were reviewed retrospectively. The overall diverticulosis prevalence was 1.97% and out of this, 85.3% was right-sided. Prevalence does not change, significantly, on trends between the period 2004–2014. The peak of prevalence of diverticulosis was compared between the female group aged >70 years to the male one of 41–50 years. The other peak, otherwise, was compared between the group of 51–60 years with the right-sided diverticulosis to the one of >70 years with left-sided disease. Multivariate analysis suggested that the male gender could be a risk factor for diverticulosis in the group aged ≤70 years, but not for the older patients. In addition, among men was registered an increased risk factor for right-sided diverticulosis and, at the same time, a protective one for left-sided localization. In conclusion, the prevalence of colonic diverticulosis is very low in mainland China and it does not change significantly on trends over the time. Both the prevalence of this condition and its distribution changes according to the age and the genders. These findings may lead the researchers to investigate the mechanisms causing this kind of disease and its distribution in regard of the age and the gender.
CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage
Authors: Chang Yan , Jia Xiaoyi , Wei Fang , Wang Chun , Sun Xiaojing , Xu Shu , Yang Xuezhi , Zhao Yingjie , Chen Jingyu , Wu Huaxun , Zhang Lingling , Wei Wei 
Published: May 2016

AbstractPaeoniflorin-6′-O-benzene sulfonate (code: CP-25), a novel ester derivative of paeoniflorin (Pae), was evaluated in rats with adjuvant-induced arthritis (AA) to study its potential anti-arthritic activity. AA rats were treated with CP-25 (25, 50, or 100 mg/kg) from days 17 to 29 after immunization. CP-25 effectively reduced clinical and histopathological scores compared with the AA groups. CP-25-treated rats exhibited decreases in pro-inflammatory cytokines (IL-1β, IL-6, IL-17 and TNF-α) coupled with an increase in the anti-inflammatory cytokine TGF-β1 in the serum. CP-25 treatment inhibited M1 macrophage activation and enhanced M2 macrophage activation by influencing cytokine production. Decreases in Th17-IL-17 and the Th17-associated transcription factor RAR-related orphan receptor gamma (ROR-γt) dramatically demonstrated the immunomodulatory effects of CP-25 on abnormal immune dysfunction. In addition, CP-25 suppressed the production of receptor activator of nuclear factor kappa B ligand (RANKL) and matrix metalloproteinase (MMP) 9, which supported its anti-osteoclastic effects. The data presented here demonstrated that CP-25 significantly inhibited the progression of rat AA by reducing inflammation, immunity and bone damage. The protective effects of CP-25 in AA highlight its potential as an ideal new anti-arthritic agent for human RA.
Preventing High Fat Diet-induced Obesity and Improving Insulin Sensitivity through Neuregulin 4 Gene Transfer
Authors: Ma Yongjie , Gao Mingming , Liu Dexi 
Published: May 2016

AbstractNeuregulin 4 (NRG4), an epidermal growth factor-like signaling molecule, plays an important role in cell-to-cell communication during tissue development. Its function to regulate energy metabolism has recently been reported. This current study was designed to assess the preventive and therapeutic effects of NRG4 overexpression on high fat diet (HFD)-induced obesity. Using the hydrodynamic gene transfer method, we demonstrate that Nrg4 gene transfer in mice suppressed the development of diet-induced obesity, but did not affect pre-existing adiposity and body weight in obese mice. Nrg4 gene transfer curbed HFD-induced hepatic steatosis by inhibiting lipogenesis and PPARγ-mediated lipid storage. Concurrently, overexpression of NRG4 reduced chronic inflammation in both preventive and treatment studies, evidenced by lower mRNA levels of macrophage marker genes including F4/80, Cd68, Cd11b, Cd11c, and macrophage chemokine Mcp1, resulting in improved insulin sensitivity. Collectively, these results demonstrate that overexpression of the Nrg4 gene by hydrodynamic gene delivery prevents HFD-induced weight gain and fatty liver, alleviates obesity-induced chronic inflammation and insulin resistance, and supports the health benefits of NRG4 in managing obesity and obesity-associated metabolic disorders.
Coupled crystal orientation-size effects on the strength of nano crystals
Authors: Yuan Rui , Beyerlein Irene J. , Zhou Caizhi 
Published: May 2016

AbstractWe study the combined effects of grain size and texture on the strength of nanocrystalline copper (Cu) and nickel (Ni) using a crystal-plasticity based mechanics model. Within the model, slip occurs in discrete slip events exclusively by individual dislocations emitted statistically from the grain boundaries. We show that a Hall-Petch relationship emerges in both initially texture and non-textured materials and our values are in agreement with experimental measurements from numerous studies. We find that the Hall-Petch slope increases with texture strength, indicating that preferred orientations intensify the enhancements in strength that accompany grain size reductions. These findings reveal that texture is too influential to be neglected when analyzing and engineering grain size effects for increasing nanomaterial strength.
Interface Engineering of Organic Schottky Barrier Solar Cells and Its Application in Enhancing Performances of Planar Heterojunction Solar Cells
Authors: Jin Fangming , Su Zisheng , Chu Bei , Cheng Pengfei , Wang Junbo , Zhao Haifeng , Gao Yuan , Yan Xingwu , Li Wenlian 
Published: May 2016

AbstractIn this work, we describe the performance of organic Schottky barrier solar cells with the structure of ITO/molybdenum oxide (MoOx)/boron subphthalocyanine chloride (SubPc)/bathophenanthroline (BPhen)/Al. The SubPc-based Schottky barrier solar cells exhibited a short-circuit current density (Jsc) of 2.59 mA/cm2, an open-circuit voltage (Voc) of 1.06 V, and a power conversion efficiency (PCE) of 0.82% under simulated AM1.5 G solar illumination at 100 mW/cm2. Device performance was substantially enhanced by simply inserting thin organic hole transport material into the interface of MoOx and SubPc. The optimized devices realized a 180% increase in PCE of 2.30% and a peak Voc as high as 1.45 V was observed. We found that the improvement is due to the exciton and electron blocking effect of the interlayer and its thickness plays a vital role in balancing charge separation and suppressing quenching effect. Moreover, applying such interface engineering into MoOx/SubPc/C60 based planar heterojunction cells substantially enhanced the PCE of the device by 44%, from 3.48% to 5.03%. Finally, we also investigated the requirements of the interface material for Schottky barrier modification.
Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder
Authors: Young C B , Chen T , Nusslock R , Keller J , Schatzberg A F , Menon V 
Published: May 2016

AbstractAnhedonia, the reduced ability to experience pleasure in response to otherwise rewarding stimuli, is a core symptom of major depressive disorder (MDD). Although the posterior ventromedial prefrontal cortex (pVMPFC) and its functional connections have been consistently implicated in MDD, their roles in anhedonia remain poorly understood. Furthermore, it is unknown whether anhedonia is primarily associated with intrinsic ‘resting-state’ pVMPFC functional connectivity or an inability to modulate connectivity in a context-specific manner. To address these gaps, a pVMPFC region of interest was first identified using activation likelihood estimation meta-analysis. pVMPFC connectivity was then examined in relation to anhedonia and general distress symptoms of depression, using both resting-state and task-based functional magnetic resonance imaging involving pleasant music, in current MDD and healthy control groups. In MDD, pVMPFC connectivity was negatively correlated with anhedonia but not general distress during music listening in key reward- and emotion-processing regions, including nucleus accumbens, ventral tegmental area/substantia nigra, orbitofrontal cortex and insula, as well as fronto-temporal regions involved in tracking complex sound sequences, including middle temporal gyrus and inferior frontal gyrus. No such dissociations were observed in the healthy controls, and resting-state pVMPFC connectivity did not dissociate anhedonia from general distress in either group. Our findings demonstrate that anhedonia in MDD is associated with context-specific deficits in pVMPFC connectivity with the mesolimbic reward system when encountering pleasurable stimuli, rather than a static deficit in intrinsic resting-state connectivity. Critically, identification of functional circuits associated with anhedonia better characterizes MDD heterogeneity and may help track of one of its core symptoms.
Breast Augmentation by Water-Jet Assisted Autologous Fat Grafting: A Report of 300 Operations
Authors: Muench Daniel 
Published: May 2016

Background The BEAULI -method (Breast Augmentation by Lipotransfer) is available for extraction and processing of large transplantable fat quantities. The aim of this work is to describe the surgical technique precisely and reproducibly and to provide an overview of the autologous fat transfer based on surgical experience.
Method The author performed 300 autologous fat transplantations on 254 women between September 3, 2010, and May 13, 2015. Patients desiring moderate volume increase, fuller and firmer breasts, as well as an optimization of the silhouette, ideally with the concurrent desire of the correction of unwanted fat deposits, were selected. The fat was extracted via water-jet assisted liposuction (Body-jet, Human Med AG, Schwerin, Germany), and the fat cells were subsequently separated with the Lipocollector® (Human Med AG, Schwerin, Germany).
Results The results were assessed with a control exam and photo comparison and were based on the responses on a questionnaire. Overall, 35.9% of the patients defined the result as very good, 38.6% as good, 22.4% as satisfactory, and 3.1% as poor.
Conclusion This study shows that the autologous fat cell transplantation into the female breast via water-jet assisted liposuction achieves a moderate and harmoniously appearing breast volume enlargement as well as contour improvement. Further studies with more cases and longer observation periods over several years could contribute to improving the method of the autologous fat transfer regarding the grow-in rate, efficiency, and safety.
Time discounting and criminal behavior
Authors: Åkerlund David , Golsteyn Bart H. H. , Grönqvist Hans , Lindahl Lena 
Published: May 2016

SignificanceOne of the most fundamental predictions of almost any model of crime is that individual time preferences matter. However, empirical evidence on this basic property of the model is essentially nonexistent. We empirically investigate whether individual time discounting measured at age 13 predicts subsequent criminal involvement up to age 31. We show that time discounting significantly predicts criminal activity and that high discount rates predict crime more strongly at the extensive margin rather than for total crime. The link is much stronger for property crime and among males with low intelligence.
Memories of unethical actions become obfuscated over time
Authors: Kouchaki Maryam , Gino Francesca 
Published: May 2016

Significance
We identify a consistent reduction in the clarity and vividness of people’s memory of their past unethical actions, which explains why they behave dishonestly repeatedly over time. Across nine studies using diverse sample populations and more than 2,100 participants, we find that, as compared with people who engaged in ethical behavior and those who engaged in positive or negative actions, people who acted unethically are the least likely to remember the details of their actions. That is, people experience unethical amnesia: unethical actions tend to be forgotten and, when remembered, memories of unethical behavior become less clear and vivid over time than memories of other types of behaviors. Our findings advance the science of dishonesty, memory, and decision making.
Biodiversity enhances reef fish biomass and resistance to climate change
Authors: Duffy J. Emmett , Lefcheck Jonathan S. , Stuart-Smith Rick D. , Navarrete Sergio A. , Edgar Graham J. 
Published: May 2016

SignificanceMarine fisheries provide a major global source of protein, feeding billions of people, but they face destabilization in many regions from overexploitation and climate change. Using the most comprehensive dataset of fish diversity and abundance, encompassing over 4,500 surveys from nearshore habitats around the world, we show that biodiversity is among the strongest predictors of reef fish community biomass, comparable in importance to global temperature gradients and human impacts. Importantly, diverse fish communities were more resistant to rising and variable temperature, suggesting that high biodiversity also buffers against changing climate. Maintaining taxonomically and functionally diverse fish communities can thus stabilize fisheries’ yields in a changing ocean.
Measuring Consumer Responses to a Bottled Water Tax Policy
Authors: Berck Peter , Moe‐Lange Jacob , Stevens Andrew , Villas‐Boas Sofia 
Published: May 2016

AbstractUsing panel data of retail purchases, we measure the effects of the introduction, and later removal, of a bottled‐water tax in the state of Washington. We use a difference‐in‐differences approach to measure effects of the tax against untreated stores (in comparable control states) and untreated weeks (the pre‐period). We further estimate triple‐difference specifications comparing bottled water to juice and milk substitute products. Our results show that, when imposed, the tax causes bottled water sales to drop by nearly 6% in our preferred specification. Sales never fully recover, even after the tax removal. In terms of the heterogeneity of this effect, we find larger quantity drops in high tax rate areas and in the lowest and highest quintile income areas.
Identifying the ‘true’ radius of the hot sub-Neptune CoRoT-24b by mass-loss modelling
Authors: Lammer H. , Erkaev N. V. , Fossati L. , Juvan I. , Odert P. , Cubillos P. E. , Guenther E. , Kislyakova K. G. , Johnstone C. P. , Lüftinger T. , Güdel M. 
Published: May 2016

Abstract
For the hot exoplanets CoRoT-24b and CoRoT-24c, observations have provided transit radii RT of 3.7 ± 0.4R⊕ and 4.9 ± 0.5R⊕, and masses of ≤5.7M⊕ and 28 ± 11M⊕, respectively. We study their upper atmosphere structure and escape applying an hydrodynamic model. Assuming RT ≈ RPL, where RPL is the planetary radius at the pressure of 100 mbar, we obtained for CoRoT-24b unrealistically high thermally driven hydrodynamic escape rates. This is due to the planet's high temperature and low gravity, independent of the stellar EUV flux. Such high escape rates could last only for &lt;100 Myr, while RPL shrinks till the escape rate becomes less than or equal to the maximum possible EUV-driven escape rate. For CoRoT-24b, RPL must be therefore located at ≈1.9–2.2R⊕ and high altitude hazes/clouds possibly extinct the light at RT. Our analysis constraints also the planet's mass to be 5–5.7M⊕. For CoRoT-24c, RPL and RT lie too close together to be distinguished in the same way. Similar differences between RPL and RT may be present also for other hot, low-density sub-Neptunes.
The Canarias Einstein ring: a newly discovered optical Einstein ring
Authors: Bettinelli M. , Simioni M. , Aparicio A. , Hidalgo S. L. , Cassisi S. , Walker A. R. , Piotto G. , Valdes F. 
Published: May 2016

Abstract
We report the discovery of an optical Einstein ring in the Sculptor constellation, IAC J010127-334319, in the vicinity of the Sculptor dwarf spheroidal galaxy. It is an almost complete ring (∼300°) with a diameter of ∼4.5 arcsec. The discovery was made serendipitously from inspecting Dark Energy Camera (DECam) archive imaging data. Confirmation of the object nature has been obtained by deriving spectroscopic redshifts for both components, lens and source, from observations at the 10.4 m Gran Telescopio CANARIAS (GTC) with the spectrograph OSIRIS. The lens, a massive early-type galaxy, has a redshift of z = 0.581, while the source is a starburst galaxy with redshift of z = 1.165. The total enclosed mass that produces the lensing effect has been estimated to be Mtot = (1.86 ± 0.23) × 1012 M⊙.
Optical variability properties of mini-BAL and NAL quasars
Authors: Horiuchi Takashi , Misawa Toru , Morokuma Tomoki , Koyamada Suzuka , Takahashi Kazuma , Wada Hisashi 
Published: May 2016

Abstract
While narrow absorption lines (NALs) are relatively stable, broad absorption lines (BALs) and mini-BAL systems usually show violent time variability within a few years via a mechanism that is not yet understood. In this study, we examine the variable ionization state (VIS) scenario as a plausible mechanism, as previously suspected. Over three years, we performed photometric monitoring observations of four mini-BAL and five NAL quasars at zem ∼ 2.0–3.1 using the 105 cm Kiso Schmidt Telescope in u, g, and i bands. We also performed spectroscopic monitoring observation of one of our mini-BAL quasars (HS 1603+3820) using the 188 cm Okayama Telescope over the same period as the photometric observations. Our main results are as follows: (1) Structure function (SF) analysis revealed that the quasar UV flux variability over three years was not large enough to support the VIS scenario, unless the ionization condition of outflow gas is very low. (2) There was no crucial difference between the SFs of mini-BAL and NAL quasars. (3) The variability of the mini-BAL and quasar light curves was weakly synchronized with a small time delay for HS 1603+3820. These results suggest that the VIS scenario may need additional mechanisms such as variable shielding by X-ray warm absorbers.
Introduction of Enhanced Recovery for Elective Cesarean Section Enabling Next Day Discharge: A Tertiary Centre Experience
Authors: Wrench I.J. , Allison A. , Galimberti A. , Radley S. , Wilson M.J. 
Published: May 2016

(Int J Obstet Anesth. 2015;24(2):124–130)
Enhanced recovery programs (fast-track surgery) are designed to optimize aspects of patient care after surgery in order to improve recovery and facilitate earlier discharge without reducing quality of care or patient satisfaction. There is mounting evidence linking enhanced recovery programs to improved patient outcomes postoperatively, including reduced patient morbidity, reduced length of stay, and earlier return to normal activities.
Influenza Virus Infection in Pregnancy: A Review
Authors: Meijer W.J. , van Noortwijk A.G. , Bruinse H.W. , Wensing A.M. 
Published: May 2016

(Acta Obstet Gynecol Scand. 2015;94:797–819)
In most patients, the influenza virus is a self-limiting infection. However, this common infection can lead to more serious complications among pregnant women.
Emergency Peripartum Hysterectomy: Results From the Prospective Nordic Obstetric Surveillance Study (NOSS)
Authors: Jakobsson M. , Tapper A.M. , Colmorn L.B. , Lindqvist P.G. , Klungsøyr K. , Krebs L. , Børdahl P.E. , Gottvall K. , Källén K. , Bjarnadóttir R.I. , Langhoff-Roos J. , Gissler M. 
Published: May 2016

(Acta Obstetricia et Gynecologica Scandinavica. 94 (2015) 745–754)
When hemorrhage is so severe and uncontrollable that it threatens the life of a parturient, an emergency peripartum hysterectomy may be performed. Emergency hysterectomies are used only after conservative treatments have failed and are the last option to prevent maternal morbidity or even death.
Monitoring Obstetric Anesthesia Safety Across Hospitals Through Multilevel Modeling
Authors: Guglielminotti J. , Li G. 
Published: May 2016

(Anesthesiology. 2015;122(6):1268–1279)
In 2001, the Agency for Healthcare Research and Quality released a list of 27 patient safety indicators. The number 1 indicator was the rate of complications of anesthesia. To ensure that this indicator remains relevant and reliable across hospitals, logistic models are used for risk adjustment that take into account patient characteristics and the types of procedures.
Delivery of Breech Presentation at Term Gestation in Canada, 2003 to 2011
Authors: Lyons J. , Pressey T. , Bartholomew S. , Liu S. , Liston R.M. , Joseph K.S. 
Published: May 2016

(Obstet Gynecol. 2015;125:1153–1161)
Publication of the Term Breech Trial led to an immediate decline in vaginal breech delivery in many countries, as the trial found that perinatal mortality and serious neonatal morbidity was significantly lower after planned cesarean delivery than after planned vaginal delivery.
Carbetocin at Cesarean Delivery for Labour Arrest: A Sequential Allocation Trial to Determine the Effective Dose
Authors: Nguyen-Lu N. , Carvalho J.C. , Farine D. , Seaward G. , Ye X.Y. , Balki M. 
Published: May 2016

(Can J Anesth. 2015;62:866–874)
Currently, oxytocin is the primary drug used to reduce the incidence of postpartum hemorrhage. However, oxytocin does have limitations, including a half-life of only 4 to 10 minutes, administration by means of an intravenous infusion, and a high rate of dose-dependent adverse effects. In contrast, carbetocin is administered as a single intravenous dose, but the recommended dosages are not well established. The authors of this study sought to determine an effective dose of carbetocin to provide satisfactory uterine tone following an intrapartum cesarean delivery in parturients whose labors were augmented.