bluuebunny/crossref_metadata_2025_split huggingface dataset:
Roles ofST2,IL‐33 andBNPin predicting major adverse cardiovascular events in acute myocardial infarction after percutaneous coronary intervention
Authors: Wang Yan‐Peng , Wang Jian‐Hua , Wang Xiao‐Long , Liu Jun‐Yi , Jiang Fang‐Yun , Huang Xiao‐Li , Hang Jing‐Yu , Qin Wei , Ma Shi‐Xin , Zhang Jie , Yuan Min‐Jie , Li Jing‐Bo , Lu Zhi‐Gang , Wei Meng 
Published: June 2017

AbstractThis study investigated roles of serumST2,IL‐33 andBNPin predicting major adverse cardiovascular events (MACEs) in acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Blood samples were collected from the includedAMIpatients (n = 180) who underwentPCI. All patients were divided into theMACEs andMACEs‐free groups. Enzyme‐linked immunosorbent assay was performed to measure serum levels ofST2,IL‐33 andBNP. Severity of coronary artery lesion was evaluated by Gensini score. Pearson correlation analysis was used. A receiver operating characteristics curve was drawn to evaluate the potential roles ofST2,IL‐33 andBNPin predictingMACEs, and Kaplan–Meier curve to analyse the 1‐year overall survival rate. Logistic regression analysis was conducted to analyse the independent risk factors forMACEs. Compared with theMACEs‐free group, the serum levels ofST2,IL‐33 andBNPwere significantly higher in theMACEs group. Serum levels ofST2,IL‐33 andBNPwere positively correlated with each other and positively correlated with Gensini score. The area under curves ofST2,IL‐33 andBNP, respectively, were 0.872, 0.675 and 0.902. The relative sensitivity and specificity were, respectively, 76.27% and 85.92%, 69.49% and 58.68%, as well as, 96.61% and 77.69%. Serum levels ofST2,IL‐33 andBNPwere independent risk factors forMACEs. The 1‐year overall survival rate was higher inAMIpatients with lower serum levels ofST2,IL‐33 andBNP. In conclusion, serum levels ofST2,IL‐33 andBNPhave potential value in predictingMACEs inAMIpatients undergoingPCI.
5‐aminosalicylic acid agents for prevention of recurrent diverticulitis: A systematic review and meta‐analysis
Authors: Urushidani Seigo , Kuriyama Akira , Matsumura Masami 
Published: June 2017

AbstractBackground and AimPrevalence of colonic diverticulosis is increasing worldwide with age, and up to 25% of patients who have colonic diverticulosis might experience diverticulitis. However, a definitive approach of preventing recurrent diverticulitis remains unknown. 5‐aminosalicylic acid (5‐ASA) agents are anti‐inflammatory agents and have been used to prevent recurrent diverticulitis, and there have been some randomized clinical trials (RCTs). However, the efficacy results for secondary prevention in uncomplicated diverticulitis differed across studies. Our aim was to clarify the efficacy and safety of 5‐ASA agents in the prevention of recurrent diverticulitis.MethodsWe searched MEDLINE, EMBASE, Web of Science, and the Cochrane library with no language restrictions. Two reviewers independently assessed and selected RCTs. The data were pooled using a random effect model and were presented in the pooled risk ratio (RR) and 95% confidence interval (CI). Cochrane's Q and I‐squared statistics were used to assess heterogeneity. The protocol was registered at PROSPERO.ResultsSeven articles with eight RCTs from 329 potentially relevant articles were included. 5‐ASA agents were not superior to controls in preventing recurrent diverticulitis (RR 0.86, 95% CI 0.63 to 1.17, I2 = 60%) and the incidence of adverse events was not different between 5‐ASA agents and controls (RR 0.97, 95% CI 0.84 to 1.11, I2 = 45%). However, some included studies were few in number of participants and substantial risk of bias.Conclusions5‐aminosalicylic acid agents were not associated with prevention of recurrent diverticulitis.
Arabidopsis TOR signaling is essential for sugar‐regulated callus formation
Authors: Lee Kyounghee , Seo Pil Joon 
Published: June 2017

SummaryDedifferentiation is a remarkable process that produces pluripotent stem cells from differentiated somatic cells to ensure developmental plasticity. Plants have evolved the ability of cellular dedifferentiation, and signaling cascades related to auxin and cytokinin‐dependent callus formation have been extensively investigated. However, the molecular mechanism underlying sugar‐dependent callus formation remains unknown. Here, we show that sugar‐dependent callus formation is mainly regulated by the TOR‐E2Fa module in Arabidopsis. Sugar‐activated TOR kinase phosphorylates and stabilizes E2Fa proteins to transcriptionally activate S‐phase genes during callus formation. In parallel, E2Fa is transcriptionally regulated by the ARF‐LBD transcription cascade. Multi‐layered regulation of E2Fa by sugar and auxin is likely to shape balanced cellular dedifferentiation capability in Arabidopsis.
Ozone‐induced foliar damage and release of stress volatiles is highly dependent on stomatal openness and priming by low‐level ozone exposure in Phaseolus vulgaris
Authors: Li Shuai , Harley Peter C. , Niinemets Ülo 
Published: June 2017

AbstractAcute ozone exposure triggers major emissions of volatile organic compounds (VOCs), but quantitatively, it is unclear how different ozone doses alter the start and the total amount of these emissions, and the induction rate of different stress volatiles. It is also unclear whether priming (i.e. pre‐exposure to lower O3 concentrations) can modify the magnitude and kinetics of volatile emissions. We investigated photosynthetic characteristics and VOC emissions in Phaseolus vulgaris following acute ozone exposure (600 nmol mol−1 for 30 min) under illumination and in darkness and after priming with 200 nmol mol−1 O3 for 30 min. Methanol and lipoxygenase (LOX) pathway product emissions were induced rapidly, followed by moderate emissions of methyl salicylate (MeSA). Stomatal conductance prior to acute exposure was lower in darkness and after low O3 priming than in light and without priming. After low O3 priming, no MeSA and lower LOX emissions were detected under acute exposure. Overall, maximum emission rates and the total amount of emitted LOX products and methanol were quantitatively correlated with total stomatal ozone uptake. These results indicate that different stress volatiles scale differently with ozone dose and highlight the key role of stomatal conductance in controlling ozone uptake, leaf injury and volatile release.
Level of acceptance of islet cell and kidney xenotransplants by personnel of hospitals with and without experience in clinical xenotransplantation
Authors: Abalovich Adrian , Matsumoto Shinichi , Wechsler Carlos J. , Carulla Mariana E. , Siciliano Martín E. , Sznaider Daniel , Denner Joachim , Elliott Robert B. 
Published: June 2017

AbstractBackgroundRecently, significant progress in both safety and efficacy has been achieved in the field of xenotransplantation, as exemplified by results from the first clinical trials of porcine islet transplantation. It would be of interest to learn whether the attitude of the clinical staff involved in such trials changes as the trials are carried out in their own hospital.MethodsOne hundred and four clinical staff members from the Eva Peron Hospital of San Martin (Buenos Aires, Argentina) where clinical trials of islet xenotransplantation have been performed and 92 similar staff members from the Diego Thompson Hospital (Buenos Aires, Argentina) where no such xenotransplantation has been carried out participated in the study. Data were collected anonymously using questionnaires.ResultsStatistically significant differences between the acceptance of xenotransplantation by clinical personnel in a hospital that had carried out clinical xenotransplantation trials were observed when compared with the acceptance of a similar staff from the hospital that had not carried out such trials.ConclusionThis study shows that involvement in clinical xenotransplantation trials significantly changes the attitude of the clinical staff towards this technology and suggests that better information given to the society may increase acceptance of the xenotransplantation.
Experiences of non-specialist nurses caring for patients and their significant others undergoing transitions during palliative end-of-life cancer care: a systematic review
Authors: Thorn Hrønn , Uhrenfeldt Lisbeth 
Published: June 2017

EXECUTIVE SUMMARY

Background
Non-specialist nurses, who are providing palliative end-of-life cancer care to patients and significant others undergoing psychosocial and existential transitions, may experience dissatisfaction, frustration and sorrow. On the other hand, they may also experience happiness, increased knowledge and personal growth.

Objective/question
What are non-specialist nurses’ experiences when providing palliative end-of-life cancer care that involves the psychosocial and existential transitions of their patients and significant others?

Inclusion criteria Types of participants
The current review considered studies that included a description of the experiences of non-specialist trained registered nurses (RNs) working in non-specialist wards.

Phenomena of interest
The current review considered studies that investigated experiences of RNs when providing palliative end-of-life cancer care that involves the psychosocial and existential transitions of their patients and significant others.

Context
The contact and care for patients and their significant others during palliative end-of-life cancer care.

Types of studies
The current review considered studies that focused on qualitative data including, but not limited to, designs such as phenomenology, grounded theory, ethnography, action research and feminist research.

Search strategy
The search aimed at finding both published and unpublished studies in English, Danish, Norwegian, Swedish and German, and was unrestricted by time. Eleven electronic databases and seven websites were searched.

Methodological quality
Methodological validity of the qualitative papers was assessed independently by two reviewers using the standardized critical appraisal instruments from the Joanna Briggs Institute Qualitative Assessment and Review Instrument (JBI-QARI).

Data extraction
Data were extracted from papers included in the review using the standardized data extraction tool from the JBI-QARI.

Data synthesis
Qualitative research findings were synthesized using the JBI-QARI.

Results
A total of 81 findings were extracted from the three studies and allocated to five categories and merged into a meta-synthesis with the overarching synthesized finding related to the challenges that non-specialist nurses faced when providing palliative end-of-life cancer care. The summary of findings is illustrated below.

Conclusion
The studies in this review provided useful and credible statements from non-specialist nurses working in non-specialist wards about their challenges when providing palliative end-of-life cancer care to patients and their significant others undergoing psychosocial and existential transitions.
Effects of dexamethasone on sugammadex reversal times of rocuronium: a systematic review protocol
Authors: Held Cassie R. , Sullivan Mackenzie D. 
Published: June 2017

Review question/objective:
The objective of the review is to identify the effect of dexamethasone on reversal times of rocuronium when utilizing sugammadex as the reversal agent. The incidence of the prolonged time to extubation in patients who have received concurrent dexamethasone and sugammadex therapies as opposed to those who have not received dexamethasone will also be examined.
The proposed PICO question is as follows: In patients undergoing reversal of aminosteroidal neuromuscular blockade with rocuronium, does dexamethasone administration affect sugammadex reversal times, as compared to patients who have not received dexamethasone?
Effectiveness of teaching strategies to improve critical thinking in nurses in clinical practice: a systematic review protocol
Authors: da Costa Carbogim Fábio , de Oliveira Larissa Bertacchini , de Campos Guilherme Gushiken , de Araújo Nunes Esther Alves , Alves Katiusse Rezende , de Araújo Püschel Vilanice Alves 
Published: June 2017

Objectives
The aim of this review is to identify and synthesize the best available evidence on the effectiveness of teaching strategies aimed at improving critical thinking (CT) in registered nurses who provide direct patient care. Specifically, the research question is: What are the best teaching strategies to improve CT skills in registered nurses who provide direct patient care?
Absolute clinical skill decay in the medical, nursing and allied health professions: a scoping review protocol
Authors: Maehle Valerie , Cooper Kay , Kirkpatrick Pamela 
Published: June 2017

Review questions/objectives:
The objective of this scoping review is to examine and map absolute clinical skill decay in the medical, nursing and allied health professions and to map the range of approaches used to address decay of clinical skills in these professions.
Specifically, the review questions are: which clinical skills, performed by which professional groups, are reported to be most susceptible to absolute clinical skill decay, and what approaches have been reported for addressing absolute clinical skill decay in the medical, nursing and allied health professions?
In addressing the review questions, the following sub-questions will also be addressed:Which healthcare settings have been investigated in relation to addressing absolute clinical skill decay?What are the characteristics of the approaches used to address absolute clinical skill decay in the medical, nursing and allied health professions?Which outcomes have been utilized when investigating approaches to addressing absolute clinical skill decay?

It is anticipated that this scoping review will inform further systematic review/s on the topic of addressing clinical skill decay in the medical, nursing and allied health professions, as well as identify gaps in the research knowledge base that will inform further primary research.
Medication safety programs in primary care: a scoping review protocol
Authors: Khalil Hanan , Roughead Libby 
Published: June 2017

Review objective/question:
The objective of this scoping review is to examine the characteristics of medication safety programs in the primary care setting and to map evidence on the outcome measures used to assess the effectiveness of medication safety programs in improving patient safety.
The current review will be guided by the following research questions:What are the types of medication safety programs described in literature on primary care?What are the outcome measures reported in studies addressing medication safety programs in primary care assessing patient safety?
Indicators to measure pre-hospital care quality: a scoping review protocol
Authors: Pap Robin , Lockwood Craig , Stephenson Matthew , Simpson Paul 
Published: June 2017

Review question/objective:
: The current scoping review seeks to locate, examine and describe international literature on indicators used to measure pre-hospital care quality. Specifically, the review will:Map attributes of definitions or descriptions of “quality” in the context of pre-hospital care provided by ambulance services.Chart indicators that have been developed to measure pre-hospital care quality and detail their development processes as well as how the indicators fit into respective measurement frameworks/matrixes.
Efficacy of a respiratory physiotherapy intervention for intubated and mechanically ventilated adults with community acquired pneumonia: a systematic review protocol
Authors: van der Lee Lisa , Hill Anne-Marie , Patman Shane 
Published: June 2017

Review objectives:
The objective of the review is to map evidence on the efficacy of a respiratory physiotherapy intervention for intubated and mechanically ventilated adults with community acquired pneumonia (CAP). Specifically, the review seeks to investigate if respiratory physiotherapy interventions can achieve the following for intubated and mechanically ventilated adults with CAP:Improve airway clearance, respiratory mechanics and oxygenation.Reduce mechanical ventilation time, time taken to stand up and/or walk, intensive care length of stay and hospital length of stay.Improve quality of life.Reduce mortality.
Patient-reported outcomes following neoadjuvant chemotherapy or chemoradiotherapy treatment for esophageal cancer: a scoping review protocol
Authors: Trenerry Camilla , Peters Micah D. J. , Corsini Nadia , Damarell Raechel A. , Wilson Carlene , Flight Ingrid 
Published: June 2017

Review objective:
The objective of this scoping review is to identify, describe and compare studies investigating patient-reported outcomes (PROs) in esophageal cancer patients following neoadjuvant (preoperative) chemotherapy (CT) and surgery or neoadjuvant chemoradiotherapy (CRT) and surgery.
After preliminary searching of the literature and consultation with experts in the fields of esophageal cancer surgery, behavioral science, information systems and scoping review methodology, the following research objectives were defined as follows:To identify, describe and compare the characteristics and timing of PROs, specifically, psychological and somatic quality of life and symptoms, experienced by esophageal cancer patients during and/or following neoadjuvant CT or CRT.To identify and describe the instruments used to measure PROs in esophageal cancer patients following neoadjuvant CT or CRT.
The impact of the Helping Babies Survive program on neonatal outcomes and health provider skills: a systematic review protocol
Authors: Dol Justine , Campbell-Yeo Marsha , Tomblin-Murphy Gail , Aston Megan , McMillan Douglas , Richardson Brianna 
Published: June 2017

Review objective/question:
The objective of this review is to evaluate the impact of the Helping Babies Survive program on neonatal outcomes and healthcare provider knowledge and skills. This quantitative review will aim to answer the following question: What is the impact of the Helping Babies Survive modules (Helping Babies Breathe, Essential Care for Every Baby and Essential Care for Small Babies) on neonatal outcomes and health provider knowledge and skills?
Risk factors for readmission to hospital in adult patients with heart failure and reduced ejection fraction: a systematic review protocol
Authors: Schjødt Inge , Larsen Palle , Johnsen Søren Paaske , Strömberg Anna , Løgstrup Brian Bridal 
Published: June 2017

Review question/objective:
: The objective of this systematic review is to identify and synthesize the best available evidence on risk factors associated with hospital readmission at different time points within the first year after heart failure (HF) hospitalization in patients suffering from HF with reduced ejection fraction (EF).
More specifically, the question is: what are the risk factors for the prediction of hospital readmission within seven, 15, 30, 60, 90, 180 and 365 days of discharge in hospitalized patients with HF with reduced EF aged 18 years or older?
Non-alcoholic fatty liver disease, bulb carotid intima-media thickness and obesity phenotypes: results of a prospective observational study
Authors: Farcas Anca Daniela , Vonica Camelia Larisa , Golea Adela 
Published: June 2017

Aims: The objective of this prospective study was to assess the correlation between carotid intima-media thickness at the common carotid (CIMTc) and carotid bifurcation (CIMTb) level, hepatic fat accumulation, and obesity phenotypes.Material and methods: Two hundred obese adults, in which CIMTc and CIMTb thickness was determined, were included. According to body mass index (BMI) and presence of metabolic syndrome (MetS), patients were classified as metabolically healthy obese (MHO, obesity without MetS) and metabolically unhealthy obese (MUHO, obesity with MetS). MHO patients were further classified as MHO1 (obese with increased waist circumference) and MHO2 (obese with increased waist circumference plusone of the 4 criteria for MetS). Non-alcoholic fatty liver disease (NAFLD) presence was assessed by fatty liver index (FLI). Results: CIMTc and CIMTb increased with obesity phenotypes from 0.74 mm and 1.04 mm in MHO1 to 0.84 mm and 1.23 mm in MHO2 and 0.88 mm and 1.74 mm in MUHO. Obesity phenotypes were significantly correlated with CIMTb. NAFLD frequency increased from 66.0% in the MHO1 to 73.0% in the MHO2 and 84.2% in the MUHO (p<0.05). Independent of age, BMI, total cholesterol, HbA1c, and HOMA-IR, the CIMTc was significantly associated with FLI in all obesity phenotypesand CIMTb only in MHO2 and MUHO.Conclusions: Our results suggest that subclinical atherosclerosis varies according to obesity phenotypes and is correlated with the hepatic fat accumulation.
Twinkle, twinkle little stone: an artifact improves the ultrasound performance!
Authors: Gliga Mirela Liana , Chirila Cristian Nicolae , Podeanu Daniela Maria , Imola Torok , Voicu Sanda Lucia , Gliga Mihail Gheorghe , Gliga Paula Maria 
Published: June 2017

Aims: Ultrasound is a noninvasive method used for the diagnosis of urinary lithiasis. When the length of the stone is less than 5 mm, its detection may be difficult. The twinkling artifact (TwA) is an intense alternating color signal behind calcifications and stones in different organs. The aim of this paper was to evaluate the importance of the TwA in detecting kidney stones less than 5 mm in length. Material and methods: We examined 230 patients with lumbar pain or a history of kidney stones. We excluded patients with stones larger than 5 mm. 174 patients corresponded to the inclusion criteria. We performed color Doppler ultrasound and we noticed the presence of the twinkling artifact. The gold standard for the diagnosis was either computed tomography (CT) scan, intravenous urography (IVU) or the spontaneous elimination of the stones.Results: We found renal stones in 123 patients. The twinkling artifact was present in 113 cases and absent in the rest of 10 patients. In two patients the artifact was present but the stones were not confirmed by CT. The twinkling artifact had sensitivity, specificity, positive predictive value and negative predictive value of 99.12%, 90.91%, 99.12%, and 90.91% respectively.Conclusions: The twinkling artifact is a very useful color Doppler ultrasound tool for the detection of small urinary stones. We suggest the routine use of color Doppler in all suspicious cases in order to avoid unnecessary irradiating and expensive radiological methods.