bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of a multicomponent positive psychology program to prevent gaming disorder and enhance mental wellness in primary pupils: A randomized controlled trial
Authors: Cheng Cecilia , Li Shuo , Chen Si 
Published: September 2024

AbstractBackground and AimsGaming disorder (GD) is a prevalent and complex issue that has recently been recognized as a condition that impairs mental health, underscoring the urgent need for early prevention measures. This evaluation study examined the effectiveness of the Digital Netizen Alliance (D.N.A.) program, a new multicomponent positive psychology program for preventing GD and bolstering mental wellness among Chinese children.MethodsDrawing on gamification and positive psychology principles, the program builds four key positive skills collectively referred to as the P-A-G-E framework: psychological resilience, active coping, growth mindset, and emotion regulation. A randomized controlled trial was conducted with 264 primary school pupils attending fourth, fifth, or sixth grade in Hong Kong (63% female; mean age = 10.83, SD = 1.18).ResultsThe findings revealed that participation in the program effectively promoted active coping, a growth mindset, and emotion regulation. Moreover, program participation alleviated GD symptoms and reduced negative affect. These desirable changes were fully explained by the P-A-G-E framework.Discussion and ConclusionsThe new D.N.A. program, which cultivates the positive psychology skills specified in the P-A-G-E framework, facilitates favorable psychological changes among children. These results emphasize the importance of using multicomponent frameworks for interventions targeting GD prevention.
Correlation between optical coherence tomography angiography measured vessel density and retinal nerve fiber layer thickness in moderate primary open angle glaucoma cases and normal controls
Authors: Priya R Jaya , B Radhakrishnan  , Naveena M  
Published: September 2024

: Aim of this study was to establish a correlation between findings obtained from Optical Coherence Tomography Angiography (OCT-A) and Retinal Nerve Fiber Layer (RNFL) thickness measurements in a series of moderate Primary Open Angle Glaucoma (POAG) cases and normal controls. In this observational cross-sectional study a total of 100 eyes were included, comprising 50 eyes with glaucoma and 50 control eyes without glaucoma. All participants underwent comprehensive anterior and posterior segment evaluations, intraocular pressure (IOP) measurement using Goldmann applanation tonometer, gonioscopy, visual field testing, and OCT imaging, which included OCT-A. The OCT-A imaging was performed using the RTvue XR Avanti by Optovue. Two types of analysis were conducted: a comparative analysis between the normal and glaucomatous groups using an unpaired t-test to assess differences in RNFL thickness and vessel density values, and a correlation analysis within each group to examine the strength of correlation between RNFL loss and reduction in vascular density. The results showed a significant reduction in vessel density index in all quadrants of glaucomatous eyes compared to normal eyes. Moreover, this reduced vessel density was found to be significantly correlated with the reduction in RNFL thickness in glaucoma patients. Specifically, the uperior and inferior quadrants exhibited the strongest correlation with each other. The severity of vascular compromise demonstrated a significant correlation with the extent of retinal nerve fiber loss in patients with glaucoma. OCT-A can serve as a valuable adjunct in the diagnosis of glaucoma and monitoring its progression.
Comparison of retinal nerve fiber thickness in emmetropes, myopes and hyperopes using optical coherence tomography
Authors: Gunasekaran Gokulappriya , Vendhan Ezhil , Devi Sozhama , Shiva Lavanya , Kannan R Rajesh 
Published: September 2024

Aim of this study was to analyze retinal nerve fiber layer thickness by using spectral domen Optical Coherence Tomography (OCT) in different refractive status (emmetrops, myopes and hypermetrops).A cross-sectional study involved 150 patients aged 18-40, with and without refractive errors. Three groups (Emmetropic, Myopic, Hypermetropic) were tested using spectral domain OCT after pupil dilation, comparing RNFL thickness.In this study, 150 participants were categorized into three groups: emmetropia, myopia, and hypermetropia. The age group most represented was 21-25 years, comprising 35.3% of the sample. Of the total, 80 were male (53.3%), and 70 were female. Among males, 22 patients were emmetropia, myopia in 31 and hypermetropia in 27. The mean axial length for emmetropia was 23.54 ± 0.48 SD, myopia was 24.53 ± 0.48 and hypermetropia was 22.36 ± 1.11. Hypermetropia was further categorized into low-grade 22.49 ± 1.06 SD, moderate 22.26 ± 1.12 SD and high-grade 22.45 ± 1.00 based on axial length.Myopic individuals exhibited significant RNFL thinning, particularly in the inferior and superior quadrants, resembling early glaucoma-related changes. This has implications for glaucoma suspect evaluations.
A study on intraocular pressure variation in primigravida and multigravida in trimesters of pregnancy and puerperium
Authors: Samal Arun , Mohanty Asit , Sahoo Kamala Kanta 
Published: September 2024

To study intraocular pressure variation in primigravida and multigravida in trimesters of pregnancy and puerperium.This is a cross sectional and hospital based study of intraocular pressure (IOP) assessment of 693 female patients of non-pregnant, 1 trimester, 2nd trimester and 3 trimesters of pregnancy and puerperium during routine ocular examination. This study carried out in nine groups of 77 in each group.In primigravida the mean IOP was 14.31 ± 1.78 mmHg, 14.82 ± 2.09 mmHg, 12.86 ± 1.75 mmHg in first, second and third trimesters respectively. In multigravida the mean IOP was 14.38 ±1.97 mmHg, 14.36 ± 2.01 mmHg, 12.71 ± 1.63 mmHg in first, second and third trimesters respectively. In primigravida puerperal period the mean IOP was 14.55 ± 1.88 mmHg and in multigravida puerperal period the mean IOP was 14.04 ± 2.52 mmHg. Mean IOP during whole period of pregnancy was 14.00 ± 1.87 mmHg and 13.81 ± 1.08 mmHg in primigravida and multigravida respectively. Control group IOP was 15.92 ± 2.11 mmHg.There is a trend of decrease of intraocular pressure during pregnancy and comes towards no pregnant level during puerperal period both in primigravida and multigravida. IOP decreased more towards second and third trimester of pregnancy. There was variation of IOP in primigravida and multigravida during pregnancy and puerperium. IOP was significantly low in multigravida than primigravida. The higher IOP in primigravida could be due to antenatal and postnatal anxiety and stress and sleeplessness. Pregnancy related effect on IOP is usual phenomenon and temporary.
Expert opinion on the prescription practice of artificial tear formulations for the management of dry eye disease in Indian settings: A questionnaire-based survey
Authors: Manjula S  , Kumar M Krishna 
Published: September 2024

Clinical studies suggested that Carboxymethyl cellulose (CMC) and Hyaluronic acid (HA) were equally effective in treating DED, other studies have shown that one treatment option outperforms the other.So, this study aimed to explore expert opinions on the use of artificial tear formulations for the effective treatment of dry eye disease (DED) in Indian settings, specifically focusing on prescribing practices for different severity levels of DED. The cross-sectional, questionnaire-based study in which data was collected through a multiple-response questionnaire. The questionnaire comprised 22 questions, covering various aspects such as the clinical characteristics of DED patients and the utilization of artificial tear formulations at different stages of the disease. Among the 54 respondents, 63% of them observed a higher prevalence of DED in individuals aged 25 to 40 years. Furthermore, 77.77% of respondents identified burning or stinging in the eyes as a significant symptom of aqueous deficiency in DED patients. As a first-line treatment for mild DED, 51.85% of participants recommended 0.5% Carboxymethyl cellulose (CMC) eye drops, while 44.44% suggested using combination eye drops containing polyethylene glycol and Propylene glycol (PEG-PG) for moderate DED cases. In the case of severe DED, the majority (68.52%) of respondents preferred prescribing sodium Hyaluronate (SH) eye drops.Experts have recommended the use of CMC eye drops to provide temporary relief from itchiness and pain caused by eye dryness, wind exposure or sun exposure. They have recommended the prescription of 0.5% CMC eye drops three times daily for mild DED patients.
Association of lipid profile with primary open angle glaucoma in non-obese patients
Authors: Agarwal Aashna , Singh Luxmi , Sharma Kanika , Bansal Vaishali 
Published: September 2024

Hyperlipidemia has been shown to be associated with Glaucoma as well as increased intra ocular pressure (IOP). We conducted a case control study to further study the association of Lipid profile with Primary Open Angle Glaucoma (POAG) in non-obese patients.: With the approval from Institutional Ethics Committee (ICE) and written informed consent, 100 adult patients were included in the case control study. The methods applied in the study adhered to the tenets of the declaration of Helsinki. 50 non-obese POAG patients of above 40 years aged were included as cases and another 50 without Glaucoma were taken as controls. Patients were further subjected to biochemical investigation of the serum lipid profile performed by Vitros 5600.: Mean total cholesterol, triglyceride and low-density lipoprotein (LDL) levels were found to be significantly higher in non-obese POAG cases as compared to that in controls (p&#60;0.05), whereas mean high density lipoprotein (HDL) levels were significantly lower in non-obese POAG cases as compared to that in controls (p&#60;0.001). The odds of high cholesterol levels to be associated with POAG in non-obese are statistically significant (p&#60;0.001).: The study demonstrated a relationship of serum lipid levels with risk of primary open angle glaucoma.
Study of prevalence of non-strabismic binocular vision anomalies in a tertiary centre: An important but often forgotten cause of ophthalmic headache
Authors: Shwetha Hebbale Ramakrishna , Bhat Archana , Ramesh Anisha , Maria Delmin 
Published: September 2024

To study the presence of non strabismic binocular vision anomalies in young patients presenting with headache. A prospective, non-interventional study of 110 patients was conducted for a period of one year in our tertiary eye care institute after obtaining informed consent and taking into consideration the inclusion and exclusion criteria. Patients presenting with asthenopic symptoms were subjected to thorough ophthalmic examination. After excluding refractive errors, patients were further subjected to detailed orthoptic evaluation (including accommodation and convergence assessment). Other non-ocular causes of headache were ruled out by appropriate referrals. Out of 110 patients, 33% were found to have accommodative insufficiency, 14% were having convergence insufficiency and 4% showed both accommodative and convergence insufficiency. 49% patients showed no extraocular muscle imbalance and were referred to relevant specialities for further evaluation. It is important to perform a thorough evaluation of patients presenting with headache for the presence of non strabismic binocular vision anomalies after ruling out other ophthalmic causes.
Dissolution method development and validation of brexpiprazole
Authors: Patole Mansi , Bendale Atul , Pathan Vasim , Narkhede Sushil , Revar Namrata , Jadhav Anil G 
Published: September 2024

A stability-indicating RP-HPLC method was established and validated for the determination of Brexpiprazole in bulk drug-using 1260 Infinity HPLC having column Hemochrom C-8, 25 cm X 4.6 mm x 5 µ, USP Apparatus Type II (Paddle), and sonicator. The prepared mobile phase was filtered as per the standard procedure. Analysis was carried out at wavelength 227 nm, flow rate 1ml per minute, 18-22 °C temperature, with an injection volume of 50 µl with time 21 minutes.It was found that interference of diluent and placebo is not more than 0.5% of Brexpiprazole. The individual % recovery was found to be between 97.0% to 100.0%, the linearity was within the range of 10- 60 µg mL with a Correlation Coefficient of 0.999, Slope of the regression line was found to be 1299178.9578 which means all parameters were found to be within range. In precision % RSD for % released dissolution values were found to be 99.16, in robustness, all the parameters like change in the flow rate, wavelength, and in RPM shows that the developed method was robust. The proposed approach performed well in terms of sensitivity, precision, accuracy, linearity and range, robustness. The well-known RP-HPLC method for the study of Brexpiprazole was shown to be trustworthy, as well as easy, consistent, cost-effective, and exact. For quality control or routine quantification, this method is applicable to determine Brexpiprazole in a bulk and pharmaceutical dosage form. This developed method required less time.
Phytochemical characterization and biological evaluation of lemongrass (Cymbopogon citratus) extracts: A systematic experimental study
Authors: Dwivedi Mahendra 
Published: September 2024

Lemongrass () is widely used in traditional medicine, with growing interest in its pharmacological properties. This study aims to systematically investigate the phytochemical composition and biological activities of lemongrass extracts, focusing on optimizing extraction methods and evaluating their therapeutic potential.Various extraction techniques were employed, including solvent-based methods (ethanol, methanol, and water) and green extraction approaches (ultrasound-assisted and microwave-assisted extraction). Phytochemical profiling was conducted using qualitative and quantitative techniques, including gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS). The biological activities of the extracts were assessed through in vitro assays for antioxidant (DPPH, ABTS), antimicrobial (agar diffusion), anti-inflammatory (COX inhibition), and cytotoxicity activities (on HeLa, MCF-7, and HEK-293 cell lines). Ethanol extracts showed the highest yield of bioactive compounds, including flavonoids, terpenoids, and phenolic acids. These extracts also exhibited significant antioxidant activity with DPPH and ABTS assays. The antimicrobial tests revealed strong activity against Staphylococcus aureus and Candida albicans, while the COX inhibition assay indicated notable anti-inflammatory effects. Cytotoxicity studies demonstrated selective toxicity toward cancer cell lines (HeLa, MCF-7) with minimal effects on normal cells (HEK-293). Lemongrass extracts, particularly those obtained via ethanol extraction, exhibit promising antioxidant, antimicrobial, anti-inflammatory, and anticancer properties. These findings highlight its potential for pharmaceutical and therapeutic applications, warranting further investigation in vivo and in clinical trials.
Application of Machine Learning for Crises Factor Significance Analysis
Authors: Semyonov Semyon 
Published: September 2024

This paper focuses on the main factors of economic crises. The factors are analysed via machine learning models. The article provides the detailed analysis of scientific papers of applications of machine learning for crises analysis. The article discusses an application of two machine learning algorithms, decision trees and gradient boosting. Decision trees are created by dividing data into subsets based on the value of the input features. The gradient boosting is an ensemble method, which is trained by combining many small models to create a final model. A detailed analysis of scientific research of machine learning applications for crises analysis is performed. The factors consists of macroeconomic indicators, stock market data and socio-political factors. The data is analyzed using statistical time series analysis and the data is standardized for machine learning models. Model parameters are selected based on the data using cross-validation method. The most effective models are used to analyze the significance of crises factors. The results show the potential of using machine learning models in crisis analysis. The conclusion provides with a potential for development of new tools for early detection of crises and strategic planning by government agencies. Future directions for research include improvement of statistical interpretation of machine learning results, application of more complex models and creation of real-time analysis systems.
Interaksi Nisbah Daun: Buah dan Perlakuan Pupuk Daun pada Kualitas Buah Abiu (Pouteria caimito Radlk.)
Authors: Thamara Aria , Susanto Slamet , Matra Deden Derajat , Widodo Winarso Drajad 
Published: September 2024

Abiu (Pouteria caimito Radlk.) is a plant of Sapotaceae family that can be consumed fresh, processed, or as a medical product. The fruit and leaves of this plant contain bioactive compounds. This research aims to inform the interaction between leaf:fruit ratio treatment and foliar fertilizer on the quality of the abiu fruit. The study was conducted at Kebun Balungbang Jaya, Dramaga, Bogor, West Java Province, from July 2022 to November 2022. The experiment used a factorial split plot design. The main plot was a leaf:fruit ratio treatment (N1, 45 leaves:1 fruit, and N2, 30 leaves:1 fruit) on each tertiary branch, and the tiller plot was foliar fertilizer (P1: 1 g L-1, P2: 2 g L-1, and P3: 3 g L-1), which consisted of 3 replications. The results showed that treatment of the leaf-fruit ratio and foliar fertilizer did not affect the quality of the abiu fruit. The interaction between leaf:fruit ratio and foliar fertilizer had a significant effect on ATT, as indicated by the lowest acidity value in the leaf:fruit ratio treatment of 45:1 and a fertilizer concentration of 1 g L-1 with a value of 0.12% but has no significant effect on the external and internal quality of other fruits.

Keywords: Bioactive compounds, sapotaceae, tertiary branch, titratable acidity
Respons Agronomi dan Fisiologi Genotipe Padi (Oryza sativa L.) pada Budi Daya Berkelanjutan
Authors: Subarjo Subarjo , Dulbari Dulbari , Dewi Ratna 
Published: September 2024

Efforts to maintain rice production in the future face many challenges, including the availability of increasingly narrow land, attacks by plant pest organisms, and declining land fertility due to improper cultivation systems. More than 70% of rice fields are in a disturbed ecological status due to cultivation technology that could be more environmentally friendly, which can interfere with the sustainability of rice self-sufficiency. An environmentally friendly rice cultivation system needs to be developed. This study aims to measure the agronomic and physiological responses of 3 rice genotypes in sustainable cultivation systems. The experiment used a Group Random Design on 3 rice genotypes (black, red, and white) in both conventional and sustainable cultivation systems. The research was carried out in the experimental garden of Polinela Organic Farm, Lampung State Polytechnic, from September 2020 to September 2021. The results showed that the plant, leaf greenery, number of tillers, number of panicles, grain weight per panicle, and biomass weight were not significantly different between conventional and sustainable cultivation. At the same time, the harvest and production indices per hectare were significantly different. The physiological responses to the photosynthesis and transpiration rates differed markedly in conventional and continuous cultivation. In contrast, the conductance of stomata did not differ significantly in both cultivation systems. The red rice genotype is the best, and it has a broader adaptation to conventional and sustainable cultivation systems.

Keywords: agronomy, conventional sysem, physiology, rice genotype, sustainable system
Pengaruh Bokashi Limbah Kulit Kopi pada Bibit Pepaya (Caraca Papaya L.) Calina
Authors: Suhada Hadisfied Rama , Trisnaningsih Umi , Wahyuni Siti 
Published: September 2024

This study aimed to determine the effect of the proportion of coffee peel bokashi in the planting medium on the growth of papaya plant seedlings (Carica papaya L.) cv Calina. The research was conducted at the Faculty of Agriculture Screenhouse on Jalan Perjuangan, Cirebon City, at an altitude of 5 m above sea level. The research was conducted from May 2022 to June 2022. The experimental method used with a completely randomized design. The treatment consisted of 4 proportions of bokashi in the planting media, each of which was repeated 6 times so that there were 24 experimental units. Each experimental unit consisted of 10 polybags. The total papaya plant seeds used were 240 seeds. The treatments studied were: K0 = top soil, K1 = 250 g bokashi + 1 kg soil, K2 = 500 g bokashi + 1 kg soil, and K3 = 750 g bokashi + 1 kg soil. The results showed that the proportion of coffee peel waste bokashi significantly affected the growth of papaya plants. Using 500 g coffee skin waste bokashi in 1 kg of soil had the best effect on plant height, stem diameter, plant growth rate, number of leaves, root volume, root length, root ratio, and net assimilation rate.

Keywords: coffee peel, bokashi, papaya
Aplikasi Ekstrak Mimosa invisa L. dan Pupuk NPK Dosis Rendah dalam Pengendalian Hama dan Patogen Padi Gogo
Authors: Rahayu Ahadiyat Yugi , Djatmiko Heru Adi , Syarifah Risqa Naila Khusna 
Published: September 2024

This study aimed to determine the effect of Mimosa invisa L. weed extract application and a low dose of NPK fertilizer on the intensity of pest attack and pathogen infection on upland rice. This research has been done using Split Plot Design with 3 replications. The main plot was the dose of NPK fertilizer (50% and 100% NPK). The subplot was the concentration of weed extract (0, 1.25, 1.67, 2.5, and 5% concentrations). The variables observed include the intensity of grasshopper and case worm attack, Cercospora sp. that causes brown spots, and Xanthomonas oryzae pv. oryzae that causes bacterial leaf blight. The results showed that the application of weed extract under a low dose (50% NPK) has not been able to suppress the intensity of grasshopper and case worm attacks, and the intensity of the pathogen causes brown spots and bacterial leaf blight. However, 2,5% and 5% concentrations of weed extract can potentially suppress pathogen infection that causes brown spots on upland rice.

Keywords: grasshopper, brown spots, Mimosa invisa L.weed extract, case worm, bacterial leaf blight, NPK fertilizer