bluuebunny/crossref_metadata_2025_split huggingface dataset:
Naked-eye 3D visualization of cultural relics based on integrated imaging
Authors: Wang Lu , Wang Yu , Liu Quanyang , Wang Qi 
Published: October 2024

Abstract
Digital technology has become crucial for the protection of cultural relics, enabling their acquisition, preservation, exhibition, and dissemination in a non-contact manner.At present, the three-dimensional(3D) visualization technology of cultural relics focuses on the research of non-true 3D visualization, which cannot provide continuous viewing angle and takes a long time to render. This paper focuses on the acquisition and reproduction of digital information related to cultural relics, and proposes to achieve the true 3D display of cultural relics from a continuous perspective based on integrated imaging(InIm). Building up on traditional InIm, an Element image array (EIA) generation algorithm based on local depth template matching is designed by using spatial geometry relation. Experimental results show that the algorithm not only enables naked-eye 3D visualization of cultural relics, but also the generation speed is more than twice that of the compared 3D display data source generation algorithm.
Mechanism of lactic acidemia-promoted pulmonary endothelial cells death in sepsis: role for CIRP-ZBP1-PANoptosis pathway
Authors: Gong Ting , Wang Qing-De , Loughran Patricia A. , Li Yue-Hua , Scott Melanie J. , Billiar Timothy R. , Liu You-Tan , Fan Jie 
Published: October 2024

Abstract
Background
Sepsis is often accompanied by lactic acidemia and acute lung injury (ALI). Clinical studies have established that high serum lactate levels are associated with increased mortality rates in septic patients. We further observed a significant correlation between the levels of cold-inducible RNA-binding protein (CIRP) in plasma and bronchoalveolar lavage fluid (BALF), as well as lactate levels, and the severity of post-sepsis ALI. The underlying mechanism, however, remains elusive.

Methods
C57BL/6 wild type (WT), Casp8−/−, Ripk3−/−, and Zbp1−/− mice were subjected to the cecal ligation and puncture (CLP) sepsis model. In this model, we measured intra-macrophage CIRP lactylation and the subsequent release of CIRP. We also tracked the internalization of extracellular CIRP (eCIRP) in pulmonary vascular endothelial cells (PVECs) and its interaction with Z-DNA binding protein 1 (ZBP1). Furthermore, we monitored changes in ZBP1 levels in PVECs and the consequent activation of cell death pathways.

Results
In the current study, we demonstrate that lactate, accumulating during sepsis, promotes the lactylation of CIRP in macrophages, leading to the release of CIRP. Once eCIRP is internalized by PVEC through a Toll-like receptor 4 (TLR4)-mediated endocytosis pathway, it competitively binds to ZBP1 and effectively blocks the interaction between ZBP1 and tripartite motif containing 32 (TRIM32), an E3 ubiquitin ligase targeting ZBP1 for proteasomal degradation. This interference mechanism stabilizes ZBP1, thereby enhancing ZBP1-receptor-interacting protein kinase 3 (RIPK3)-dependent PVEC PANoptosis, a form of cell death involving the simultaneous activation of multiple cell death pathways, thereby exacerbating ALI.

Conclusions
These findings unveil a novel pathway by which lactic acidemia promotes macrophage-derived eCIRP release, which, in turn, mediates ZBP1-dependent PVEC PANoptosis in sepsis-induced ALI. This finding offers new insights into the molecular mechanisms driving sepsis-related pulmonary complications and provides potential new therapeutic strategies.
Abnormally high plasma concentrations of M-4, the active metabolite of edoxaban, at the onset of acute kidney injury in a patient receiving rifampin and clarithromycin: a case report
Authors: Nakagawa Junichi , Ishido Keinosuke , Kimura Norihisa , Nagase Hayato , Wakasa Yusuke , Yokoyama Satoshi , Ueno Kayo , Hakamada Kenichi , Niioka Takenori 
Published: October 2024

Abstract
Background
Edoxaban, the only factor Xa inhibitor with active metabolites, is metabolized by carboxylesterase-1 to its main active metabolite, M-4, which is a substrate of organic anion transporting polypeptide 1B1 (OATP1B1) and is excreted in bile and urine. Because the area under the plasma concentration–time curve ratio of M-4 to parent compound is typically less than 10% in healthy subjects, M-4 is generally considered to exhibit negligible antithrombotic activity in patients treated with edoxaban. However, we identified a case in which drug interactions and kidney impairment led to a substantive increase in plasma M-4 concentrations.

Case presentation
This case report involved a 68-year-old man with pancreatic cancer who was orally administered edoxaban tablets for prevention of thrombus formation in non-valvular atrial fibrillation, in addition to rifampin and clarithromycin (CAM) for treatment of mycobacterium avium complex lung disease. These medications were temporarily discontinued for a pancreaticoduodenectomy but were resumed 8 days post-surgery (POD8). On POD9, the patient developed acute kidney injury, and the trough concentrations of edoxaban and M-4 were 131.1 ng/mL and 115.8 ng/mL, respectively (M-4 ratio: 88.3%). On POD11, the M-4 trough concentration and M-4 ratio increased to 216.2 ng/mL and 186.2%, respectively. The plasma concentration of coproporphyrin-I, an endogenous biomarker of OATP1B1 activity, increased during this period.

Conclusions
This case suggests that in patients with impaired renal function taking edoxaban, co-administration of carboxylesterase-1 inducers such as rifampin and/or OATP1B1 inhibitors such as rifampin or clarithromycin may increase plasma concentrations of M-4 to clinically non-negligible levels.
Stapler-induced vascular injury during uniportal VATS lobectomy: lessons learned from a rare complication case
Authors: Nakashima Yasuhiro , Hanafusa Mariko , Ishibashi Hironori , Hosoda Hiroshi 
Published: October 2024

Abstract
Background
Due to advances in video-assisted thoracic surgery (VATS), the majority of lung resections can be performed safely via VATS with low morbidity and mortality. However, pulmonary artery (PA) bleeding often requires emergency conversion to thoracotomy, potentially leading to a life-threatening situation. We report a case of pulmonary artery injury caused by an unexpected stapler-tissue interaction during uniportal VATS lobectomy, highlighting the importance of recognizing and managing such rare complications to improve patient outcomes.

Case presentation
A 63-year-old man underwent uniportal VATS left upper lobectomy for a suspected primary lung cancer. During the procedure, unexpected bleeding occurred from the third branch of the pulmonary artery (A3) after withdrawal of an unfired stapler. The protruding staple of the A3 stump was inadvertently hooked and stretched by the groove of the staple anvil. Although the bleeding was controlled by compression with the lung, the injured A3 stump required repair. Due to the extensive intimal injury near the central part of the left main pulmonary artery and the potential risk of fatal postoperative complications, we converted to open thoracotomy for definitive vascular repair by suturing. The patient had no postoperative complications and was discharged on postoperative day 8.

Conclusions
This case report provides valuable lessons regarding the rare stapler-related vascular injury during uniportal VATS lobectomy. It is important to note that even during non-vascular dissection, unexpected stapler-tissue interactions can lead to bleeding. To prevent the vessel stump entanglement with stapler components, maintaining separation between the stapler and staple stumps is crucial. In uniportal VATS, manipulation during stapler insertion is one of the most challenging phases for instrument interference, requiring increased caution to prevent complications such as the vascular injury described in this case. Thorough preoperative planning, specific intraoperative precautions, and adapted safety protocols that address the limitations of uniportal VATS are essential for effective management of potential complications. Although techniques for thoracoscopic vascular control exist, they are not always feasible and conversion to open thoracotomy should be considered when necessary to ensure patient safety.
Effect of group psychotherapy on self-care skills in schizophrenia
Authors: Sayed Shymaa Mohammed , Ahmed Gellan K. , Abdullah Saleh O. , Khalifa Sanaa Mostafa 
Published: October 2024

Abstract
Background
Schizophrenia is a serious neurodevelopmental psychiatric disorder that places a considerable strain on the healthcare system on a national, regional, and global scale. This study's objective was to measure the level of self-care among individuals with schizophrenia. In addition, to develop, implement, and evaluate the impact of 3 month group therapy on self-care skills in this specific group of patients. The sample comprised 120 individuals diagnosed with schizophrenia, with 60 assigned to study group (receiving group therapy) and 60 to control group (without group therapy). The Positive and Negative Syndrome Scale (PANSS) and The Exercise of Self-Care Agency Scale (ESCAS) were administered to all subjects. The study group observed a substantial decrease in the mean score of positive symptoms, negative symptoms, and symptoms of general psychopathology from baseline assessment to follow-up assessment.

Results
During the follow-up assessment, the study group exhibited a reduction in the mean of PANNS subscales by more than half and increase more than double in total score of ESCAS compared to the baseline assessment. Consequently, only the study group achieved a 70% increase in self-care in follow-up assessment. Increased self-care was more likely in patients who participated in the program, as indicated by the regression model.

Conclusions
Individuals with schizophrenia who underwent group therapy exhibited a significant decrease in positive, negative symptoms, and symptoms of general psychopathology. In addition, the implementation of group therapy led to a noticeable improvement in self-care skills compared to those without group therapy.
Mechanism of metabolic memory: progression in diabetic nephropathy—a descriptive review
Authors: Begum Farhana , Lakshmanan Karpagavel 
Published: October 2024

AbstractDiabetes mellitus and its complications exploit significantly impact global human well-being and economic burden. Previous studies and clinical trials have provided insights into the concept of metabolic memory, which sustains even after hyperglycemia has been resolved, causing diabetic complications completely. The term “metabolic memory” refers to the body’s abnormal metabolism, which can have long-term effects and influence both health and disease conditions. It involves various molecular processes causing cellular shifts, tissue and organ dysfunctions, disease progression, and effects on offspring. The conceptual framework of metabolic memory is defined and strengthened, offering a comprehensive understanding of the underlying causes of diabetic nephropathy (DN) and providing a potential new approach for diagnosing and treating the disease. In this review, we elucidated the importance, characteristics, cellular and molecular importance, and therapeutic intervention to eradicate metabolic memory in DN once hyperglycemia has been eliminated. The regulation of metabolic memory is assisted based on an epigenetic mechanism. Therefore, this report traces the significant factors involved in regulating epigenetic modifications such as DNA methylation, histone modification, and chromatin remodeling. This mechanism significantly triggers epigenetic regulation, leading to glucose stress, oxidative stress induction, and apoptosis, causing DN. It occurs beyond various signaling cascades, resulting in alterations in transcription factors and receptor molecules, which enhance the metabolic memory in the post-sustenance of hyperglycemia. This condition can be modulated based on therapeutic interventions involving lifestyle modification and the inclusion of natural substances like bioactive compounds, polyphenols, and terpenoids in the diet, followed by medications acting as epigenetic modifiers.
Effect of body mass index on quadriceps angle and tibial torsion in school-aged children
Authors: Elhoseny Hanaa Ahmed , Eltohamy Amira Mohamed , Diab Olfat Abdelrahman 
Published: October 2024

Abstract
Background
The prevalence of excessive body mass (BMI) is increasing in pediatric population. Accordingly, the number of musculoskeletal problems in this population is also likely to increase. The quadriceps angle (Q-angle) is a clinical measure used to measure knee alignment in relation to the hip, femur, and tibia, as well as evaluating alignment of the patella. Tibial torsion (T.T) is an important morphological feature of human tibia. The aim of that study was to study the relationship between the Q-angle and TT in children 8 to 12 years old, the effect of BMI on Q-angle and T.T, and the difference in Q-angle and TT between dominant and non-dominant side.

Results
“Seventy-five children from primary schools” were enrolled in the study and allocated into 3 groups (25 subjects in each group), according to BMI: group I (normal weight = 25), group II (overweight = 25), and group III (obese = 25). The mean value of age of groups I, II, and III was 10.35 ± 1, 10.74 ± 1.2, and 10.17 ± 1.18 years respectively; the mean value of weight was 29.88 ± 3.94, 43.68 ± 6.55, and 50.06 ± 10.44 kg respectively; the mean value of height was 135.28 ± 7.63, 143.2 ± 8.85, and 140.72 ± 9.3 cm respectively; and the mean value of BMI was 16.22 ± 1, 21.18 ± 1.4, and 25.17 ± 2.67 kg/m2. The number (%) of boys in groups I, II, and III was 15 (60%), 18 (72%), and 17 (68%) respectively and of girls was 10 (40%), 7 (28%), and 8 (32%) respectively.
The significant values were Q-angle and TT. Data were expressed as mean ± SD. ANOVA was used to compare between subjects’ characteristics of the groups. Kolmogorov-Smirnov test was used for testing normality of data distribution. One-way MANOVA was used to compare parametric variables (Q-angle and TT) between the two groups. Compared with normal weight children, there was statistically significant increase in Q-angle and TT angle in overweight and obese children.

Conclusion
Any change in BMI would eventually lead to change in both Q-angle and TT angle. The greater the BMI values, the greater the values of Q-angle and TT angle.
The functions of apolipoproteins and lipoproteins in health and disease
Authors: Ma Zijun , Zhong Jixin , Tu Wei , Li Shiliang , Chen Jun 
Published: October 2024

AbstractLipoproteins and apolipoproteins are crucial in lipid metabolism, functioning as essential mediators in the transport of cholesterol and triglycerides and being closely related to the pathogenesis of multiple systems, including cardiovascular. Lipoproteins a (Lp(a)), as a unique subclass of lipoproteins, is a low-density lipoprotein(LDL)-like particle with pro-atherosclerotic and pro-inflammatory properties, displaying high heritability. More and more strong evidence points to a possible link between high amounts of Lp(a) and cardiac conditions like atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis (AS), making it a risk factor for heart diseases. In recent years, Lp(a)'s role in other diseases, including neurological disorders and cancer, has been increasingly recognized. Although therapies aimed at low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) have achieved significant success, elevated Lp(a) levels remain a significant clinical management problem. Despite the limited efficacy of current lipid-lowering therapies, major clinical advances in new Lp(a)-lowering therapies have significantly advanced the field. This review, grounded in the pathophysiology of lipoproteins, seeks to summarize the wide-ranging connections between lipoproteins (such as LDL-C and HDL-C) and various diseases, alongside the latest clinical developments, special emphasis is placed on the pivotal role of Lp(a) in cardiovascular disease, while also examining its future potential and mechanisms in other conditions. Furthermore, this review discusses Lp(a)-lowering therapies and highlights significant recent advances in emerging treatments, advocates for further exploration into Lp(a)'s pathogenic mechanisms and its potential as a therapeutic target, proposing new secondary prevention strategies for high-risk individuals.
Investigating the behavior of vertical trapezoidal CSSWs stiffened with flat steel plate
Authors: Shen Lisen 
Published: October 2024

AbstractSteel shear wall (SSW) is an efficient system used to construct and improve many structures over the past decades. The main weakness of the traditional flat plate SSW is the premature buckling of the plate, for which the corrugated steel shear wall (CSSW) is a suitable alternative. However, the reduced resistance of CSSW compared to flat SSWs is a disadvantage. In this research, their reinforcement by flat steel plates with different dimensions and thicknesses has been used to improve the behavior of vertical trapezoidal steel shear walls (VTSSW). The samples studied in this research were subjected to cyclic loading after verification in Abaqus finite element software. The outcomes showed that reinforcing CSSWs with flat plates increased strength and energy absorption between 6 to 63% and 16 to 92%, respectively. Also, the equivalent viscous damping has increased between 5 and 82%. Also, due to strengthening the CSSWs, the pinching phenomenon in the hysteresis curves has been reduced, and the sudden decrease in strength after buckling in the CSSWs without stiffener has been significantly reduced.
Quantum nonlocality of density operators and their corresponding density matrices
Authors: Hu K. F. , Guo Z. H. , Cao H. X. , Lu L. 
Published: October 2024

Abstract
Quantum nonlocality represents correlations between subsystems of a composite quantum system, usually including Bell nonlocality, steerability, and entanglement. According to the hypothesis of quantum mechanics, states of a quantum system Q described by a d-dimensional Hilbert space

are denoted by density operators acting on

. Under a basis e for the Hilbert space

, every abstract density operator ρ of the system AB corresponds to a density matrix ρ

e
, which is a state of the

complex Hilbert space

. In this work, we discuss the consistency of quantum nonlocality of density operators ρ and their corresponding density matrices ρ

e
under the chosen basis e. It is proved that only when a basis e is a product one, a density operator ρ is entangled (respectively, Bell nonlocal, steerable) if and only if its density matrix ρ

e
is entangled (respectively, Bell nonlocal, steerable).
Laparoscopic-Assisted Peritoneal Access in Ventriculoperitoneal Shunt Placement: Systematic Review and Meta-Analysis
Authors: Abdelmageed Sunny , Sarkar Prottusha , Shlobin Nathan A. , Davila Daniel G. , Potts Matthew B. 
Published: October 2024

BACKGROUND AND OBJECTIVES:
The most common treatment of hydrocephalus is ventriculoperitoneal (VP) shunting. Peritoneal access is commonly conducted through an open laparotomy, but laparoscopic peritoneal access is gaining popularity. Many studies have reported the benefits of minimally invasive laparoscopic peritoneal access, but there is no consensus on its use. We conducted a systematic review and meta-analysis to compare open laparotomy vs laparoscopic peritoneal access in VP shunting.

METHODS:
A systematic search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines using 3 databases. Twelve studies included only adults, 3 included only pediatric patients, and 3 included both adults and pediatric patients.

RESULTS:
Compared with open laparotomy, laparoscopic peritoneal access was associated with a reduction in distal shunt failure (6.1% vs 2.2%, P = .01), operative time (69.4 vs 56.3 minutes, P < .001), and length of stay (LOS) (9.6 vs 7.3 days, P < .001). There were no differences in proximal shunt failure, total shunt failure, intraoperative complications, or infection rate. In the pediatric population, laparoscopic access was associated with a reduced LOS (7.8 vs 5.9 days, P < .001). Heterogeneity was high but explained by the varying study populations and techniques.

CONCLUSION:
Laparoscopic peritoneal access for VP shunt insertion is associated with improved outcomes, including reduced distal shunt failure, reduced operative time, and reduced hospital LOS, when compared with open laparotomy and should be considered for shunt insertion. Additional studies are necessary to further determine the benefit of laparoscopic access, especially in the pediatric population.
Binocular camera calibration using a BP algorithm optimized by an improved subtraction-average-based optimizer
Authors: Hao Haixia , Liu Ji , Wu Jinhui , Chen Yabo , Chen Wei 
Published: October 2024

The BP algorithm exhibits drawbacks such as reduced precision and extended iteration
duration during the process of calibrating a binocular
camera system. A technique employing an improved
subtraction-average-based optimizer to optimize the BP algorithm
(ISABO-BP) is introduced to address these limitations and complete the
calibration of the binocular camera. The pixel values of the corner in
2D space and the coordinate values in 3D space are used as the input
and output for the BP algorithm, respectively. First, the logistic
chaotic mapping is used to initialize the population to increase the
diversity of the initial population. The piecewise mapping is employed
to generate random values to replace the coefficient values in the
individual position update formula, making the population distribution
more uniform. The golden sine strategy is adopted to help particles
escape from local optima. The ISABO-BP algorithm is utilized to
perform the process of calibrating a binocular camera. Then, through
numerical experiments, the mean calibration precision for the BP
algorithm is 0.1501 and 0.0445 cm for the ISABO-BP algorithm.
The calibration precision has been enhanced by 70.4%. The iterative
steps of the BP algorithm are 353 epochs, while the ISABO-BP algorithm
are 76 epochs, and the iterative speed is increased by nearly four
times. It is evident that the ISABO-BP algorithm enhances the
calibration precision and expedites the convergence rate. Finally,
other intelligent algorithms to optimize the BP algorithm for
calibrating a binocular camera are compared, and the superiority of
this algorithm is also verified.
45 W kHz-linewidth single-frequency fiber laser at 1120 nm
Authors: Peng Yan , Zheng Junjie , Li Wei , Yang Huan , Liu Wei , Pan Zhiyong , Chen Zilun , Xiao Hu , Ma Pengfei , Wang Zefeng , Xu Shanhui 
Published: October 2024

Single-frequency fiber lasers (SFFLs) at 1120 nm have been widely used in biochemical analysis applications by generating 560 nm lasers. Here, we investigate the capacity of large-mode-area Yb-doped fiber for 1120 nm single-frequency laser amplification. By optimizing the length of large-mode-area Yb-doped fiber to balance the amplified spontaneous emission and stimulated Brillouin scattering effect, the output power of the 1120 nm SFFL could be enhanced to 45 W with a slope efficiency of 59.9%. At the maximum power level, the optical signal-to-noise ratio, the linewidth, and the beam quality of the output laser are 45 dB, 7.03 kHz, and M
x
2=1.52/M
y
2=1.49, respectively. Our study proves that using large-mode-area fiber in cooperation with a gain coefficient and fiber length optimization is promising to improve the output power of 1120 nm SFFL. And the experimental results provide implications for the expansion of Yb-doped single-frequency lasers to the wavelength above 1100 nm.