bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bird Phylogenetic Diversity Increases With Temperature Worldwide
Authors: Barrios Pelayo , Martinez‐Nuñez Carlos 
Published: October 2024

ABSTRACTAimTemperature significantly influences the composition and structure of biotic communities at large scales. While its role in shaping taxonomic diversity is well‐documented, its relationship with other facets of biodiversity, like phylogenetic diversity, remains poorly known. Understanding how and to which extent temperature contributes to global patterns of phylogenetic diversity compared to other biodiversity‐structuring factors is crucial for comprehending how bird assemblages are structured worldwide, predicting their response to global‐change drivers and supporting conservation policies focused on preserving bird genetic diversity and evolutionary history.LocationWorldwide.MethodsWe analyse the role of temperature in predicting bird regional phylogenetic richness (PD) and divergence (MPD) worldwide, before and after controlling for the effect of species richness (SR). We also assess the shape of this relationship in different biogeographic realms and compare its explanatory power with other key biodiversity‐structuring factors such as elevation, human impact index, net primary productivity and land use diversity.ResultsOur findings underscore the high significance and consistency of temperature as a key predictor positively associated with bird PD and MPD across the six main biogeographic realms, even after accounting for SR and latitude, suggesting that temperature modulates the intrinsic capacity of environments to support a diverse array of lineages. In addition, PD and MPD tended to increase at low elevations, but the human‐impact index did not effectively predict bird phylogenetic diversity at this scale. Furthermore, high PD was linked to regions with high primary productivity and high land‐use diversity, although both of these relationships were strongly mediated by SR.ConclusionsThis study unveils the key role of temperature in explaining bird phylogenetic diversity worldwide over other key biodiversity‐structuring factors and points to the profound implications that climate change will have on the amount of evolutionary history held in bird assemblages, beyond species extinctions or range shifts alone.
A randomized phase I study of BI 1820237, a novel neuropeptide Y receptor type 2 agonist, alone or in combination with low‐dose liraglutide in otherwise healthy men with overweight or obesity
Authors: Beetz Nadine , Kalsch Brigitte , Forst Thomas , Schmid Bernhard , Schultz Armin , Hennige Anita M. 
Published: October 2024

AbstractAimsPharmacotherapeutic options for obesity treatment include glucagon‐like peptide‐1 receptor (GLP‐1R) agonists, for example, liraglutide. However, an unmet need remains, particularly in patients with a high body mass index (BMI), as GLP‐1R agonists are associated with gastrointestinal adverse events (AEs) and some patients do not respond to treatment. Neuropeptide Y (NPY) and peptide YY bind G‐protein‐coupled Y receptors and represent attractive targets for modulating bodyweight.Materials and MethodsThis first‐in‐human, three‐part, partially blinded phase I study (NCT04903509) investigated the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of the peptidic NPY2R agonist BI 1820237, with/without low‐dose liraglutide: part 1 (participants randomized to receive BI 1820237: 0.075–2.4 mg or placebo), part 2 (BI 1820237: 1.2 mg or placebo) and part 3 (BI 1820237: 0.025–1.2 mg + liraglutide 0.6 mg or placebo + liraglutide 0.6 mg). Primary endpoint is the proportion of participants with drug‐related AEs. Secondary endpoints are tolerability, PK and PD.ResultsIn total, 95 otherwise healthy men with increased BMI (25.0–34.9 kg/m2) were randomized. Drug‐related AEs, mainly gastrointestinal events, were reported by 39.0% of participants (n = 23) in parts 1 + 2 and 30.6% of participants (n = 11) in part 3; one drug‐related AE (11.1%, part 3) was reported in a participant receiving placebo with liraglutide. Post‐dose paracetamol PK suggested that BI 1820237 and low‐dose liraglutide exhibited additive effects on gastric emptying.ConclusionsBI 1820237 treatment was associated with transient nausea and vomiting at higher doses. No differences in tolerability were observed when combined with liraglutide; effects on gastric emptying appeared additive.
ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function
Authors: Dicenta‐Baunach Valerie , Laspa Zoi , Schaale David , Sigle Manuel , Bayrak Alp , Castor Tatsiana , Pillaiyar Thanigaimalai , Laufer Stefan , Gawaz Meinrad Paul , Rohlfing Anne‐Katrin 
Published: October 2024

AbstractBackgroundPlatelet receptors ACKR3 and CXCR4 play a crucial role in a variety of cardiovascular diseases. Like most chemokine receptors, CXCR4 is a G protein coupled receptor that induces platelet activation. In contrast, the atypical chemokine receptor 3 (ACKR3) lacks the ability to activate heterotrimeric G proteins and its activation leads to platelet inhibition and attenuates thrombus formation. In nucleated cells, heterodimerization of ACKR3 with CXCR4 regulates CXCL12‐dependent signalling. The aim of our study was to investigate the formation of ACKR3/CXCR4 heterodimers in platelets and the subsequent consequences for platelet function.Methods and ResultsUsing a proximity ligation assay (PLA, Duolink®) to screen for CXCR4/ACKR3 heterodimerization inducing compounds, we found that ACKR3 agonism but not conventional platelet agonists or endogen ligands lead to heterodimer formation. To further characterize the formation of ACKR3/CXCR4 heterodimers, we studied the CXCL12‐dependent platelet activation via CXCR4. Both, CXCL12‐dependent platelet aggregation and collagen‐dependent ex vivo thrombus formation were significantly downregulated by ACKR3 agonism. Moreover, platelet intracellular calcium and Akt signalling were increased by CXCL12 and again suppressed by ACKR3‐specific agonists. Previously, CXCL12 was shown to decrease platelet cAMP levels via CXCR4. Treatment with a specific ACKR3 agonist counteracted this CXCL12/CXCR4‐dependent cAMP decrease.ConclusionOur results reveal that the formation of platelet ACKR3/CXCR4 heterodimers is dependent on ACKR3 rather than CXCR4. Furthermore, ACKR3 agonism induced heterodimerization is associated with mitigating CXCL12/CXCR4‐dependent platelet activation possibly by modulating CXCR4‐dependent G protein signalling. Our results indicate possible ACKR3 agonist functions and reinforce the potential therapeutic applications of ACKR3 agonists.
A newly developed, easy‐to‐use prehospital drug‐derived score compared with three conventional scores: A prospective multicenter study
Authors: Jurado‐Palomo Jesús , Martin‐Conty José Luis , Polonio‐López Begoña , Bernal‐Jiménez Juan J. , Conty‐Serrano Rosa , Dileone Michele , Castro Villamor Miguel A. , del Pozo Vegas Carlos , López‐Izquierdo Raúl , Rivera‐Picón Cristina , Martín‐Rodríguez Francisco , Sanz‐García Ancor 
Published: October 2024

AbstractIntroductionThe use of medications by emergency medical services (EMS) is increasing. Conventional scores are time‐consuming and therefore difficult to use in an emergency setting. For early decision‐making, an easy‐to‐use score based on the medications administered by the EMS may have prognostic value. The primary objective of this study was to develop the prehospital drug‐derived score (PDDS) for 2‐day mortality.MethodsA prospective, multicenter, ambulance‐based cohort study was conducted in adults with undifferentiated acute diseases treated by EMS and transferred to the emergency department. Demographic data, prehospital diagnosis data, prehospital medication and variables for the calculation of the National Early Warning Score 2 (NEWS2), Rapid Emergency Medicine Score (REMS), and Rapid Acute Physiology Score (RAPS) were collected. The PDDS was developed and validated, establishing three levels of risk of 2‐day mortality. The predictive capability of each score was determined by the area under the curve of the receiver operating characteristic curve (AUROC) and compared using the Delong's test (p‐value).ResultsA total of 6401 patients were included. The PDDS included age and the use of norepinephrine, analgesics, neuromuscular blocking agents, diuretics, antihypertensive agents, tranexamic acid, and bicarbonate. The AUROC of PDDS was .86 (95% CI: .816–.903) versus NEWS2 .866 (95% CI: .822–.911), p = .828; versus REMS .885 (95% CI: .845–.924), p = .311; versus RAPS .886 (95% CI: .846–.926), p = .335, respectively.ConclusionThe newly developed easy‐to‐use prehospital drug‐derived PDDS score has an excellent predictive value of early mortality. The PDDS score was comparable to the conventional risk scores and therefore might serve as an alternative score in the prehospital emergency setting.
A Joanna Briggs Institute Framework Approach to Shared Decision Making in End‐of‐Life
Authors: Glaría Marta Gil , Fernández María Martín , Salgado Carla , Hernández‐Leal María José 
Published: October 2024

ABSTRACTAimTo implement shared decision‐making (SDM) through a patient decision aid (PtDA) for the initiation of palliative care (PC) in end‐of‐life (EOL) cancer patients.MethodologyA comprehensive Scoping Review was conducted on SDM in PubMed, CINAHL and PsycInfo. An evidence‐based implementation of PtDAs was created using the Joanna Briggs Institute framework, which followed rigorous pillars: (1) context, (2) facilitation and (3) evaluation.ResultsFifteen studies were identified and categorised into (1) Implementation characteristics and (2) Strategies for implementing SDM in terminally ill cancer patients. SDM should consider the decision‐making location, optimal timing, participants and decision type. Strategies include professional training, PtDAs and implementation programmes. A PtDA implementation protocol in video format for deciding to initiate PC is proposed, following International Patient Decision Aid Standards (IPDAS) and Clinical Practice Guidelines (CPG).ConclusionsSDM implementation should be guided by evidence‐based methodological models justifying and structuring its execution, especially in complex and interdisciplinary contexts. National or international frameworks facilitate the adoption of health innovations, such as PtDAs, benefiting patients and improving their usage.Practice ImplicationsSDM is not just a concept but an important approach to the Care of cancer patients at EOL, enhancing patient satisfaction and improving care quality. The success and sustainability of SDM hinge on the fundamental aspects of staff training, interdisciplinary collaboration and ongoing evaluation. The lack of specific aid in Spanish underscores the immediate need for local development. Further research is needed in this area, as most reviewed studies did not measure SDM effectiveness in diverse hospital settings.Patient or Public ContributionThis proposal was developed based on the experience and input of the nursing staff from the healthcare service where it is intended to be implemented.
Comparison of the safety and efficacy of laparoscopic single‐incision triangulated umbilical surgery pyeloplasty with traditional three‐hole surgery in a pediatric tertiary center
Authors: Lu Liangsheng , Zhang Bin , Tang Liangfeng , Shen Jian , Wang Xiang , Geng Hongquan 
Published: October 2024

ObjectiveTo report the application of laparoscopic single‐incision triangulated umbilical surgery (SITUS) pyeloplasty in children with ureteropelvic junction obstruction (UPJO) and compare its feasibility and efficacy with traditional three‐hole laparoscopic pyeloplasty.MethodsData from children with UPJO who underwent SITUS between July 2018 and August 2021 were included in this retrospective study and patients who were treated with traditional laparoscopic pyeloplasty were chosen for comparison. Thirty‐two patients from SITUS group and 72 patients from traditional group were reviewed. The clinical characteristics, complications, and follow‐up results were collected and compared.ResultsThe preoperative demographic data and imaging parameters, including sex, surgical side, age, BMI, and preoperative anterior–posterior pelvic diameter (APD), showed no significant differences between the two groups. The median surgical time was 135 min (IQR: 119.75–160.5) in SITUS group, while 163.5 min (IQR: 141.25–187.5) in the traditional group (p = 0.0008). Two Clavien‐Dindo III complications (6.25%) in SITUS group and 11 (15.3%) in the traditional group were recorded (p = 0.335). The success rate was 100% (32/32) in SITUS group and 94% (68/72) in the traditional group (p = 0.309).ConclusionSITUS pyeloplasty is a feasible and effective laparo‐endoscopic single‐site (LESS) technique for pediatric patients with excellent cosmetic results comparable to the conventional laparoscopic pyeloplasty. More cases and longer follow‐up periods are needed to determine the exact outcomes of the modified LESS technique.
Hierarchical materials with interconnected pores from capillary suspensions for bone tissue engineering
Authors: Nider Souhaila , De Ceulaer Femke , Göksel Berfu , Braem Annabel , Koos Erin 
Published: October 2024

AbstractThe increasing demand for bone grafts due to the aging population has opened new opportunities for the manufacture of porous ceramics to assist in bone reconstruction. In our study, we investigate a new, promising method to manufacture hierarchically porous structures in a straightforward and tunable way. It consists of combining the novel technology of capillary suspensions, formed by mixing solid particles and two immiscible liquids, one less than 5 vol%, with freeze casting. We have successfully achieved alumina and beta‐tricalcium phosphate (β‐TCP) materials with both <2 µm and 20–50 µm as the smallest and largest pore sizes, respectively. The microstructure exhibits fully open pores and high levels of porosity (>60%). The capillary suspensions’ rheological behavior indicates that silica nano‐suspensions as a secondary fluid creates a stronger internal particle network than sucrose for the alumina system. Conversely, the opposite was observed with the β‐TCP system. These differences were attributed to the change in affinity between the secondary fluids and the solid loading. In our study, both systems have served to deepen the knowledge about the new area of capillary suspensions and proved their use in hierarchical porous scaffolds for bone tissue engineering.
Aggressive Behaviour Risk Assessment Tool for Hospitalised Patients in Non‐Psychiatric Inpatient Units
Authors: Kim Son Chae , Vejnovich Chris , Hall Lyndsi , Rawlings Melinda , Thompson Karissa 
Published: October 2024

ABSTRACTAimTo refine and validate an electronic version of the Aggressive Behaviour Risk Assessment Tool (ABRAT) and determine the sensitivity and specificity for identifying potentially violent patients in non‐psychiatric inpatient units.DesignA prospective cohort study design was used.MethodsAll patients admitted or transferred to three inpatient units of an acute care hospital in Nebraska, USA, from 7 February to 9 April 2023, were included. The 10‐item ABRAT assessments were performed daily for the first 3 days of admission. The violent events were collected until discharge in three categories: Physical aggression towards others, physical aggression towards property and verbal intimidation/threat towards others. Kendall's tau tests and a multivariate logistic regression procedure were performed to select a parsimonious set of items that best predict violent events.ResultsOf 1179 patients, 69 had ≥1 violent event (5.9%). The revised six‐item tool with item weighting was named ABRAT for Hospitalised Patients (ABRAT‐H). The area under the curve from the Receiver Operating Characteristics analysis was 0.82. The sensitivity and specificity at a cutoff score of two were 68.1% and 85.2%, respectively. As ABRAT‐H scores increased, the percentage of violent patients also increased and for patients with scores ≥5, 55.2% became violent.ConclusionABRAT‐H appears to be useful for identifying potentially violent patients in non‐psychiatric inpatient units with satisfactory sensitivity and specificity.Implications for Patient CareThe availability of ABRAT‐H may help provide focused preventive measures that target patients at high risk for violence and reduce violent events.ImpactA majority of the nursing workforce is employed in acute care hospital setting, and the availability of ABRAT‐H can further enhance the culture of a safe work environment and have positive impacts not only on the nurses' physical and mental health but also on the quality of patient care.Reporting MethodWe have adhered to relevant STROBE guidelines for reporting observational studies.Patient or Public ContributionNo Patient or Public Contribution.
Research Review: Pharmacological and non‐pharmacological treatments for adolescents with attention deficit/hyperactivity disorder – a systematic review of the literature
Authors: Sibley Margaret H. , Flores Sabrina , Murphy Madeline , Basu Hana , Stein Mark A. , Evans Steven W. , Zhao Xin , Manzano Maychelle , van Dreel Shauntal 
Published: October 2024

BackgroundAttention Deficit/Hyperactivity Disorder (ADHD) demonstrates unique developmental manifestations in adolescence with implications for optimized, age‐appropriate treatment. This 10‐year update is the third in a series of systematic reviews examining the efficacy and safety of adolescent ADHD treatments. We broadly examined efficacy on ADHD symptoms, impairments, and other reported outcomes. Acute and long‐term efficacy, and treatment moderators, were considered.MethodWe performed PubMed, EMBASE, and PsycINFO searches for articles published or in press from 2013 to 2024, integrated with hand search and randomized controlled trials (RCTs) identified in this series' earlier reviews. RCTs examining the safety or efficacy of interventions delivered to adolescents (ages 10.0–19.9) with a diagnosis of ADHD were included. Study characteristics were extracted and reviewed, quality of evidence was assessed using GRADE, and effect sizes were calculated for individual studies and illustrated using forest plots.ResultsSixty‐three RCTs were identified. Quality of evidence ranged from high (medication; k = 29) to very low (nutrient supplementation, neurofeedback, occupational therapy; k = 1 each). Medications demonstrated consistent strong impact on ADHD symptoms and inconsistent impact on impairment. Diverse cognitive/behavioral treatments (C/BTs) demonstrated inconsistent impact on ADHD symptoms but strong and consistent impact on impairment and executive function skills, plus moderate benefits on internalizing symptoms. No interventions demonstrated significant safety concerns. Long‐term maintenance (up to 3 years post‐treatment) was demonstrated for C/BTs, though moderate quality of evidence was noted because participants cannot be fully blinded to receipt of treatment.ConclusionsThe effects of C/BTs and medication appear complementary, not duplicative. Combining medication and C/BT is advised at treatment outset to maximize engagement, maintenance, and response breadth (i.e. improving both ADHD symptoms/cognitive performance and coping skills/functional impairments). Engagement strategies (e.g. motivational interviewing) may facilitate uptake. Novel treatments do not yet demonstrate effects on ADHD symptoms or impairments in adolescents but remain a promising area for research.
Hidden species diversity in the Enteromius Cope, 1867 (Teleostei: Cyprinidae) from the Aruwimi basin (Middle Congo) in the Okapi Wildlife Reserve (Democratic Republic of the Congo)
Authors: Mayo Ilodiri Wilson , Huyghe Charlotte E. T. , da Costa Luis M. , Mambo Baba Taylor , Danadu Mizani Célestin , Vreven Emmanuel J. W. M. N. 
Published: October 2024

AbstractTwo new African minnow species, Enteromius cerinus sp. nov. and Enteromius ruforum sp. nov., are described for science from the Angadiko River, a left‐bank sub‐affluent of first order of the Nepoko River, draining the north‐eastern part of the Okapi Wildlife Reserve (OWR). Both new species belong to the group of Enteromius for which the last unbranched dorsal‐fin ray is flexible and underrated. Within this morphological group, both are most similar to Enteromius kamolondoensis, especially in life colour pattern characteristics. However, Enteromius cerinus sp. nov. differs from E. kamolondoensis by its low number of circumpeduncular scales, 10–11 (vs. 12), low maximum body depth, 22.8%–25.7% standard length (Ls) (vs. 26.1%–30.0%), and long anterior and posterior barbel lengths, 32.6%–35.3% head length (LH) (vs. 23.6%–27.2%) and 41.6%–43.9% LH (vs. 30.3%–34.9%), respectively. Further, E. ruforum sp. nov. is also easily distinguished from E. kamolondoensis by its high maximum body depth, 30.6%–33.3% Ls (vs. 26.1%–30.0%), and small, isometric, eye diameter, 26.2%–28.0% LH (vs. 29.1%–31.9%). A barcoding study (mtDNA, cytochrome oxidase subunit I [COI]) revealed that specimens of both new species form lineages well differentiated from those of other available species. As such, (i) E. cerinus sp. nov. diverges from E. kamolondoensis by a K2P genetic distance (GD) of 10.3% and (ii) E. ruforum sp. nov. by a K2P GD of 11.2%. To the present day, the fish fauna of the left‐bank sub‐affluents of the Nepoko River, in general, remains poorly known or undocumented. Unfortunately, at the same time, multiple anthropogenic impacts are affecting this fauna, such as (i) the destruction of habitats along the river banks for agriculture and fishing and (ii) the use of illegal fishing practices, such as fishing with plant‐based ichthyotoxins during ecopage, which is combined with dam building. As a result of the demographic growth, this ecopage results in overfishing and thus is threatening both new species in particular, but all other co‐occurring fish species as well. Both new species, E. cerinus sp. nov. and E. ruforum sp. nov., should thus be considered Vulnerable (VU) according to IUCN criterion D2. It is therefore hoped that their discovery highlights the urgent need for a better protection and further in situ exploration of the reserve's freshwater (fish) biodiversity, in general, and that of those small sub‐affluents, in particular.