bluuebunny/crossref_metadata_2025_split huggingface dataset:
IOT system architecture for the diagnosis of Parkinson's disease using neural networks and OSTIS
Authors: Vishniakou U. A. , Xia I. W. 
Published: September 2024

The purpose of this work is to develop an IT diagnostic system for Parkinson's disease (PD) with remote access based on the Internet of Things (IoT) network.Methods. The authors have developed a method for complex recognition of Parkinson's disease using machine learning, based on markers of voice analysis and changes in patient movements on known datasets. In the architecture of the Internet of Things network, a smartphone is the point of initial data collection and preprocessing, including extracting features from an audio recording of the patient's voice and his motor activity. Data is transmitted via a local Flask server, which acts as a channel for sending functional data to the Open Semantic Technology for Intelligent Systems (OSTIS) server. The OSTIS server processes the data received from the local Flask server and uses a neural network prediction agent to recognize BP. This agent downloads features and makes predictions based on a trained neural network, linking these predictions with knowledge in the OSTIS system, and stores them in a database.The result of the study is the architecture and algorithms of the IoT network. The workflow of the entire system includes data collection and preprocessing by the Internet of Things device, subsequent data transfer to the local Flask server, further forwarding to the OSTIS server, processing of the neural network model by a neural network predictor agent and, ultimately, linking the processed results to the knowledge graph and storing them in the system.The BP remote IT diagnostics system provides real-time processing of patient data, recognition of disease signs on the Internet of Things, support for advanced analysis and decision-making for further treatment.
Reconfiguration of four-degree limited Laman graphs
Authors: Trinh Hoang Minh 
Published: September 2024

Abstract

This paper considers the problem of expanding and reducingLamangraphs, of which each vertex has at most four neighbors. To this end, several simple algorithms that can be repeatedly applied to construct or degenerate a given four-degree limitedLamangraph are proposed. The correctness of the proposed algorithms is asserted based onLaman’scriterion. Numerous examples and discussions are provided to demonstrate the applicability and impact of these algorithms.
Genomic subtypes and cellular phenotypes of high-grade endometrial carcinoma
Authors: Kawazu Masahito , Taguchi Ayumi , Yoshida Emiko , Yoshida Hiroshi , Uno Masaya , Inoue Satoshi , Yamamoto Yoko , Sakashita Shingo , Ueno Toshihide , Nakamura Yuki , Lin Jason , Kojima Shinya , Kawase Katsushige , Ishizaka Aya , Miyata Suguru , Kojima Motohiro , Ikemura Masako , Sone Kenbun , Ishikawa Mitsuya , Kato Tomoyasu , Mano Hiroyuki , Terao Yasuhisa , Oda Katsutoshi 
Published: September 2024

Abstract

Recent genomic analyses of endometrial carcinoma (EC) have delineated four distinct subtypes: ultra-mutated (POLE) type, microsatellite instability–high (MSI-H) type, copy number–high (CN-H) type, and copy number–low (CN-L) type. Despite these classifications, the relationship between genomic subtype and histological classification of high-grade EC remains obscure. This study is a comprehensive genomic analysis specifically focusing on high-grade EC. Examination of 81 high-grade EC tumors revealed that serous carcinoma is frequently characterized by TP53 mutations as described previously. However, the correspondence between genomic subtype and histological classification of high-grade EC was weak overall. Gene expression–based clustering showed that clear cell carcinoma, not specifically associated with any particular genomic subtype, had high expression of glandular/lumenal cell marker genes. We also identified a subset of tumors characterized by the expression of genes related to ciliated cells. Our findings underscore the significance of considering cellular phenotypes that might reflect cell of origin and differentiation status, alongside genomic subtype, to precisely understand individual tumors of various histological types. Importantly, cellular phenotype might be closely associated with the immunological status of cancer cells; tumors with the glandular/lumenal phenotype are thought to present antigens more efficiently. Such stratification might have clinical implications, potentially impacting post-surgical adjuvant treatment or the use of immune therapy in women with high-grade EC. We propose that RNA clustering is a clinically valuable tool for the precise stratification and treatment planning for high-grade EC, emphasizing its potential to enhance personalized medicine approaches for EC.
Recurrent Founder Variant in Inherited FVII Deficiency: Molecular Spectrum Analysis in Southeast China Recurrent Founder Variant in Inherited FVII Deficiency: Molecular Spectrum Analysis in Southeast China
Authors: Ye Longying , Qin Langyi , Wang Saifang , Jin Yanhui , Yang Lihong , Wang Mingshan , Xie Yaosheng 
Published: September 2024

Abstract

Background
Factor VII (FVII) deficiency is a rare congenital coagulation disorder inherited in an autosomal recessive manner, characterized by reduced plasma FVII levels. Several variants in the F7 gene have been identified across different populations, with higher prevalence in certain regions. However, limited reports exist on predominant variants in Chinese and East Asian populations, highlighting the need for this study to fill the gap and improve understanding of genotype-phenotype correlations.
Result
This study characterizes severe FVII deficiency in 85 unrelated Chinese families, 57 exhibited severe FVII defects. Notably, 31 out of 57 experienced various bleeding manifestations, with the most prevalent being gingival bleeding, epistaxis, and menorrhagia. The Pearson's rank correlation test yielded correlation coefficients of − .496 (P = .000), − .266 (P = .014), and .149 (P = .175) between FVII activity and PT, FVII activity and bleeding scores, and PT and bleeding scores, respectively. Direct sequencing of the exons of the F7 gene and its border regions was conducted on all patients. The five variants with the highest allele frequencies were p.Arg364Gln, p.His408Gln, p.Arg337Cys, p.Cys10Profs16, and p.Cys389Gly. The p.Arg364Gln variant was identified in 11 individuals with homozygotes and 6 with compound heterozygosity, with the highest allele frequency of 30.51%. The variants p.Gln160Leu, p.Leu170*, p.Ser329Pro, and p.Trp344Gly were previously identified and reported by our research group. Additionally, a novel variant, p.Ile421Serfs76, is reported for the first time. This study, representing one of the largest cohorts of FVII variants in China, suggests that the prevalence of FVII deficiency may be underestimated. This conclusion is supported by the high proportion of asymptomatic subjects found to have low FVII levels.
Conclusion
The findings of this study, which represents one of the largest cohorts of FVII variants in China, indicate that the prevalence of FVII deficiencies may be underestimated. This is due to the high proportion of asymptomatic individuals with low FVII:C levels. The significant association between FVII:C levels, prothrombin time, and bleeding symptoms highlights the necessity for continued genetic analysis to enhance our comprehension of genotype-phenotype correlations and to refine diagnostic and management strategies for FVII deficiency in the Chinese population.
Can we improve the existing management of pain after cesarean delivery at Eastern Regional Referral Hospital? A retrospective survey
Authors: Wangchuk Tashi , Tshering Ugyen 
Published: September 2024

Abstract

Background
Pain after surgery is generally considered undertreated worldwide. This may be because of resource and skill constraints. Inadequate management of pain after cesarean delivery (CD), can adversely affect the well-being of both mothers and newborns, potentially leading to a higher incidence of chronic post-operative pain. We must therefore constantly improve the quality of pain care for CDs. This study aimed to review the existing management of pain associated with CD at Eastern Regional Referral Hospital (ERRH)
Methods
This retrospective review of the management of pain after CDs, was conducted between December 2017 and December 2018 at ERRH, Bhutan. A total of 107 CD patients were reviewed.
Results
Of the 107 patients with CDs reviewed, only 2% received analgesics before surgery, and 20% received analgesics during surgery. The majority of the patients (63%) received a single injection of Diclofenac sodium, followed by oral Ibuprofen (56%) on the following day.
Conclusions
Despite the availability of resources and skills, the present review revealed that the existing management strategy of pain after CDs at ERRH was mostly a single-drug therapy, with focus mainly on the post-operative period.
Ridge-ridge-ridge triple junction instability: Unveiling the dynamics and evolution with 3-D numerical simulations
Authors: Marques Fernando , Balazs Attila , Gerya Taras , Hildenbrand Anthony 
Published: September 2024

Abstract

The most important form of plate evolution occurs where three tectonic plates meet, a triple junction1 (TJ). Ridge-ridge-ridge (RRR) TJs are unique because they are stable at all ridge configurations and spreading velocities1. This idealised and simplified RRR TJ with three straight rifts is challenged here by showing that it does not apply if at least one rift is not straight (sigmoidal). Despite its great importance for plate tectonics, how and why a stable RRR TJ configuration becomes unstable is unclear. The state-of-the-art 3-D numerical simulations reported here using the Azores TJ (ATJ) as a prototype bring a new understanding of RRR TJ stability and evolution. The current knowledge and critical similarities in both the simulations and prototype in terms of timing, transient grabens distribution, rift and triple junction jump, diffuse plate boundary, depth of the main rift, and rift shoulder uplift indicate that the ATJ is unstable because of the sigmoidal shape of the Azores-Gibraltar fracture zone and how Nubia has moved relative to Eurasia in the last 4 Ma. Consequently, the fracture zone that turned into a first-order plate boundary became unstable, and the Azores block moved from Eurasia to Nubia.
The Effect of General Anesthesia Combined with Transversus Abdominis Plane Block on Postoperative Sleep Disorders in Elderly Patients Undergoing Gastrointestinal Tumor Surgery: A Prospective, Randomized Controlled Trial
Authors: Pu Jie , Guo Chendong , Xiao Yue , Cao Yanan , Liu Zhenhua , Jin Yuzhong , Hu Yimin 
Published: September 2024

Abstract

Purpose: This study aimed to investigate the effect of general anesthesia combined with transversus abdominis plane block on postoperative sleep disorders in elderly patients undergoing gastrointestinal tumor surgery.
Methods: We recruited 94 elderly patients diagnosed with gastrointestinal malignancies, all scheduled for radical laparoscopic surgery. The patients were allocated to two groups using the random number table method: the general anesthesia group (group GA) and the general anesthesia combined with transversus abdominis plane block group (group GT). Group GT got bilateral transversus abdominis plane blocks (TAPB) following the same induction of anesthesia as Group GA, which received the intravenous-inhalation complicated general anesthesia regimen. Wearable devices were utilized to measure sleep on the first day before surgery (P1) as well as the first and third day after surgery (D1 and D3). On P1, D1, and D3 nights, respectively, the Pittsburgh Sleep Quality Index (PSQI) scale was utilized to measure sleepiness and the occurrence of postoperative sleep disorders (POSD).
Results: The group GT demonstrated a significant decrease in the usage of remifentanil during surgery (P<0.05) as compared to the group GA. At D1, there was a substantial decrease in the number of awake (P<0.05) and an increase in the ratio of deep sleep to rapid eye movement sleep (REM) in the GT group. The percentage of REM was still rising at D3, and PSQI values at D1 and D3 were considerably lower (P<0.05). Furthermore, there was a decreasing tendency (P<0.05) in the incidence of POSD and the visual analog scores (VAS) at 0.5 and 6 hours after surgical activity in D1. The overall condition, intraoperative state, remedial analgesia, and number of analgesic pump presses did not differ significantly between the two groups (P>0.05).
Conclusion: General anesthesia combined with transversus abdominis plane block can improve the postoperative sleep quality of elderly patients with gastrointestinal tumors and reduce the incidence of sleep disorders.
Preventive and Therapeutic Efficacy of Thalidomide in Paclitaxel-Induced Peripheral
Authors: Yi Hai-Zhen , Chen Jin-Jing , Lv Wei , Lin Zhan 
Published: September 2024

Abstract

Purpose: The main adverse effects of paclitaxel chemotherapy are arthralgia, myalgia, and neuropathic pain. The objective of this research was to assess the potential preventive benefits, continuous management strategies, and the likelihood of remission and recurrence of these symptoms after Thalidomide treatment.
Methods: This retrospective study reviewed the medical histories of 120 cancer patients who experienced arthralgia, myalgia, and neuropathic pain while undergoing paclitaxel chemotherapy at The First People’s Hospital of Yulin, Guangxi, from March 2022 to December 2023. The patients were stratified into two groups according to whether they received Thalidomide or not: with Thalidomide (n = 48) or without Thalidomide (n = 34). Pain assessments were initiated at the first sign of symptoms during the initial treatment cycle and were repeated over the next three cycles to assess the effectiveness of Thalidomide in managing symptoms and its preventive capabilities. The assessments employed the Common Terminology Criteria for Adverse Events (CTCAE) and the painDETECT questionnaire to measure the intensity of pain experienced by the patients.
Findings: At the study’s inception, the neuropathic pain score was 21.17±2.69 for the Thalidomide group and 20.24±2.47 for the non-Thalidomide group. Subsequent follow-ups revealed a dramatic reduction to 0.13±0.44 in the Thalidomide group and to 6.68±1.90 in the non-Thalidomide group.. Neuropathic pain, along with arthralgia and myalgia, was more pronounced at baseline and in the third treatment cycle. A significant difference was noted between the two groups (all p<0.05).
Implications: The findings of this research indicate that Thalidomide is effective in alleviating neuropathic paindue to paclitaxel. The preemptive application of Thalidomide proved to be exceptionally potent in providing rapid pain relief. Subsequent monitoring revealed that Thalidomide sustained its efficacy across multiple treatment cycles.
Prevalence and Associated Factors of Postoperative Nausea and Vomiting Among Pediatric Patients Undergoing Elective Surgery Under General Anesthesia at Addis Ababa Public Hospital in 2021/22: a Multi-center Cross-sectional Study
Authors: Waktasu Desta , Haddis Lidya , Seyoum Emebat , Nigussie Mistre , Amsalu Molla 
Published: September 2024

Abstract

Background: Postoperative nausea and vomiting (PONV) is a common and distressing complication following surgical procedures, affecting up to 70% of paediatric patients. PONV can lead to delayed recovery, increased hospital stay, and reduced patient satisfaction, posing a significant burden on healthcare systems. In the paediatric population, PONV is particularly concerning due to the potential risk of aspiration, dehydration, and electrolyte imbalances
Methods: A multicentre cross-sectional study method was carried out, with study population of 186 surgical paediatrics patient populations from December 1, 2021 to May 30, 2022. The magnitude of Paediatrics population was evaluated according to specific criteria encompassing socio demographic and preoperative paediatrics characteristics, intraoperative, and postoperative characteristics of paediatrics PONV.
Results: The magnitude of pediatrics PONV in PACU and Ward identified with their associated risk factors of perioperative anxiety, motion sickness and long duration of surgery and anaesthesia.
Conclusion: The magnitude of paediatrics PONV at Addis Ababa Public Hospital is 12%.Using opioid for postoperative management is not related to paediatrics PONV in our study. Reduction strategy as well as prevention and treatment are vital for enhancing paediatrics patient safety and perioperative care quality.
Improved levan production by novel Calidifontibacillus erzurumensis LEV207 using one variable at a time approach
Authors: Palkar Omkar Prakash , Rayasam Keerthi , Peddireddy Vidyullatha , Kolluru Viswanatha Chaitanya 
Published: September 2024

Abstract

Levan, an exopolysaccharide, has applications in the medical and food sectors. Under natural conditions, levan is produced at a low concentration by microorganisms. This current study focuses on optimizing levan production by a one-variable-at-a-time approach from a novel marine bacterium, Calidifontibacillus erzurumensis LEV207. The growth and levansucrase production by C. erzurumensis LEV207 were studied to optimize the media components and conditions. Sucrose and yeast extract proved to be a good levansucrase inducer. The pH of 6.0 and temperature of 30°C, along with MgSO4 as salt, increased the enzyme activity. Sucrose and yeast extract at the concentration of 50% and 1%, respectively, produced the maximum enzyme activity of 427.4 µmol/mL/min after 48 hrs of incubation. The optimization process increased the levan (EPSLEV207) production 7-fold with a final yield of 65.58 g/L. To confirm the structure and nature of EPSLEV207, NMR and XRD were performed, and the functional groups present in EPSLEV207 were determined using FTIR. Chemical hydrolysis of levan confirmed fructose as the monomer, making EPSLEV207 a homopolysaccharide. EPSLEV207 exhibited 49% and 22% radical scavenging activity against DPPH and ABTS radicals, respectively, and promoted the growth of probiotic strain. EPSLEV207 showed an 88% water solubility index and 78% water retention capacity. The optimization process has increased the yield of levan up to 7-fold, highlighting the potential of C. erzurumensis LEV207 to be a viable option for industrial applications.
Impacts of irrigation expansion on moist-heat stress: first results from IRRMIP
Authors: Yao Yi , Ducharne Agnès , Cook Benjamin , De Hertog Steven , Aas Kjetil , Arboleda-Obando Pedro , Buzan Jonathan , Colin Jeanne , Costantini Maya , Decharme Bertrand , Lawrence David , Lawrence Peter , Leung L. Ruby , Lo Min-Hui , Narayanappa Devaraju , Wieder William , Wu Ren-Jie , Zhou Tian , Jaegermeyr Jonas , McDermid Sonali , Pokhrel Yadu , Elling Maxwell , Hanasaki Naota , Muñoz Paul , Nazarenko Larissa , Otta Kedar , Satoh Yusuke , Yokohata Tokuta , Jin Lei , Wang Xuhui , Mishra Vimal , Ghosh Subimal , Thiery Wim 
Published: September 2024

Abstract

Irrigation rapidly expanded during the 20th century, thereby affecting climate via changes in water, energy, and biogeochemical cycling. Previous assessments of these historical climate effects of irrigation expansion predominantly relied on a single Earth System Model, and therefore suffered from structural model uncertainties. Here we quantify the impacts of historical irrigation expansion on climate by analysing simulation results from six Earth system models participating in the Irrigation Model Intercomparison Project (IRRMIP). Despite the large range of simulated irrigation water withdrawal from those models (~900 to ~4000 km3 after the year 2000), our results show that irrigation expansion causes a rapid increase in irrigation water withdrawal, which leads to less frequent 2-meter air temperature heat extremes across heavily irrigated areas (>4 times less likely). However, due to the irrigation-induced increase in air humidity, the cooling effect of irrigation expansion on moist-heat stress is less pronounced or even reversed, depending on the heat stress metric. In summary, this study suggests the priorities in irrigation dataset collection and parameterisation development, and shows that irrigation deployment is not an efficient adaptation measure to escalating human heat stress under climate change, calling for carefully dealing with the increased exposure of local people to moist-heat stress.
Bifunctional RhIII-complex catalyzed CO2 reduction and NADH regeneration for direct bioelectrochemical synthesis of C3 and C4
Authors: Wang Yajie , Li Hailong , Wu Yizhou , Wang Yuxuan , Zhang Kai , Zhu Jin , Ji Yuan , Gu Tao , Nie Weixuan , Sun Licheng 
Published: September 2024

Abstract

Bioelectrochemical synthesis is emerging as an eco-friendly method for CO2 fixation. These systems typically rely on electrochemically regenerated NAD(P)H to provide the necessary reducing equivalents for formate dehydrogenase (FDH) to convert CO2 into formate. However, the efficiency of these systems is currently unsatisfactory due to the unfavorable dynamics of the CO2-to-formate conversion by FDH. In this study, we developed a one-pot cooperative bioelectrochemical system featuring a rhodium-based catalyst [Cp*Rh(bpy)Cl]2+ (RhIII-complex or [RhIII-H2O]2+) working cooperatively with enzymatic cascades of acetyl-CoA synthase (ACS), acetaldehyde dehydrogenase (ACDH), alcohol dehydrogenase (ADH), formolase (FLS), and d-fructose-6-phosphate aldolase mutant FSAA129S to convert CO2 into several C2+ chemicals. The bifunctional RhIII-complex concurrently catalyzes the reduction of CO2 to formate at a rate of 15.8 mM/h and NADH regeneration at a rate of 0.24 mM/min. The formation of formate is 83.2 times faster than using one of the best aerobic FDH from Clostridium ljungdahlii (ClFDH), resulting in a 3.6 times enhanced methanol production rate of 0.43 mM/h in the bioelectroenzymatic system (RhIII-complex-ACS-ACDH-ADH) compared to that of 0.12 mM/h in tandem enzymatic system (ClFDH-ACS-ACDH-ADH). Bifunctional RhIII-complex also works cooperatively with tandem enzymatic cascades to produce dihydroxyacetone (C3) and L-erythrulose (C4) at the yield of 2.63 mM, and 1.93 mM, respectively. This study leveraged the synthetic capabilities of both electrochemical catalysis and enzymatic catalysis, offering an alternative for electroenzymatic CO2 reduction to yield value-added compounds with enhanced productivity.