bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgery for Glioblastoma in Light of Molecular Markers: Impact of Resection and MGMT Promoter Methylation in Newly Diagnosed IDH-1 Wild-Type Glioblastomas
Authors: Gessler Florian , Bernstock Joshua D , Braczynski Anne , Lescher Stephanie , Baumgarten Peter , Harter Patrick N , Mittelbronn Michel , Wu Tianxia , Seifert Volker , Senft Christian 
Published: January 2018

Abstract

BACKGROUND
Previous studies addressing the influence of surgery on the outcome of patients with glioblastomas (GBM) have not addressed molecular markers. The value of surgery versus the tumor's major biological markers remains unclear.

OBJECTIVE
We investigate the extent of resection as a prognosticator for patients with newly diagnosed primary GBM with the incorporation of molecular diagnostics as per the updated WHO 2016 diagnostic criteria for GBM.

METHODS
Patients with newly diagnosed GBM who underwent resection were prospectively included within a database. We analyzed patients with newly diagnosed GBM and excluded patients who presented with IDH1 R132H mutations. Gross total resection (GTR) was defined as complete removal of enhancing disease.

RESULTS
One hundred seventy-five patients were included within the analysis. One hundred four patients (59.4%) had GTR, 71 patients (40.6%) had subtotal or partial resection. Eighty patients (45.7%) displayed O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, 95 patients (54.3%) showed no MGMT promoter methylation. In Cox regression analysis, MGMT promoter methylation (hazard ratio [HR] 1.55; 95% confidence interval [CI], 1.01-2.19; P = .0133) and GTR (HR 1.48; 95% CI, 1.06-2.07; P = .0206) were significantly associated with favorable progression-free survival. MGMT promoter methylation (HR 2.13; 95% CI, 1.45-3.12; P = .0001) and GTR (HR 1.81; 95% CI, 1.24-2.63; P = .002) were associated with favorable overall survival (OS). Of other risk factors analyzed, age (>60 vs ≤ 60 yr) was significantly associated with progression-free survival (HR 1.60; 95% CI, 1.14-2.24; P = .006) and OS (HR 2.19; 95% CI, 1.51-3.19; P < .0001).

CONCLUSION
GTR and MGMT promoter methylation are independent prognosticators for improved overall and progression-free survival in a homogeneous cohort of newly diagnosed patients with IDH wild-type glioblastoma.
Adalimumab for Corticosteroid and Infliximab-Resistant Immune Reconstitution Inflammatory Syndrome in the Setting of TB/HIV Coinfection
Authors: Lwin Nilar , Boyle Michael , Davis Joshua S 
Published: January 2018

Abstract
Corticosteroids are the mainstay of therapy for immune reconstitution inflammatory syndrome (IRIS). However, little is known about how to treat IRIS unresponsive to steroids. We report a patient with HIV-TB coinfection who was unresponsive to first prednisolone and then infliximab but whose IRIS resolved with adalimumab.
Energy-dependent intensity variation of the persistent X-ray emission of magnetars observed with Suzaku
Authors: Nakagawa Yujin , Ebisawa Ken , Enoto Teruaki 
Published: January 2018

Abstract
The emission mechanism of magnetars is still controversial even though various observational and theoretical studies have been made. In order to investigate mechanisms of both the persistent X-ray emission and the burst emission of the magnetars, we propose a model in which the persistent X-ray emission consists of numerous micro-bursts of various sizes. If this model is correct, root mean square (rms) intensity variations of the persistent emission would exceed the values expected from the Poisson distribution. Using Suzaku archive data of 11 magnetars (22 observations), the rms intensity variations were calculated from 0.2 keV to 70 keV. As a result, we found significant excess rms intensity variations from all 11 magnetars. We suppose that numerous micro-bursts constituting the persistent X-ray emission cause the observed variations, suggesting that the persistent X-ray emission and the burst emission have identical emission mechanisms. In addition, we found that the rms intensity variations clearly increase toward higher energy bands for four magnetars (six observations). The energy-dependent rms intensity variations imply that the soft thermal component and the hard X-ray component are emitted from different regions far apart from each other.
Persistent Symptoms and Objectively Measured Balance Performance Among OEF/OIF Veterans With Remote Mild Traumatic Brain Injury
Authors: Hebert Jeffrey R. , Forster Jeri E. , Stearns-Yoder Kelly A. , Penzenik Molly E. , Brenner Lisa A. 
Published: January 2018

Objective:
To investigate linear relationships between dizziness, fatigue, and depression and posttraumatic stress disorder (PTSD) and objectively measured balance performance in Veterans with remote mild traumatic brain injury (mTBI).

Setting:
Academic laboratory; Veterans Affairs Medical Center.

Participants:
Thirty Veterans (28 men) who served in Iraq/Afghanistan and whose most recent mTBI was sustained more than 6 months prior to enrollment.

Design:
Cross-sectional, observational trial.

Main Measures:
The Computerized Dynamic Posturography-Sensory Organization Test (CDP-SOT) and the Community Balance and Mobility (CB&M) scale measured balance. Dizziness (Dizziness Handicap Inventory), fatigue (Modified Fatigue Impact Scale), depression-related symptoms (Beck Depression Inventory-II), and PTSD-related symptoms (PTSD Checklist 5) were also measured.

Results:
Objectively measured balance, CDP-SOT composite, was impaired (mean score of 67.9). CDP-SOT scores correlated with dizziness (r = −0.53; P = .002), fatigue (r = −0.38; P = .03), depression (r = −0.55; P = .001), and PTSD symptoms (r = −0.53; P = .002). Dizziness, time since most recent mTBI, and PTSD symptoms and depression combined explained significant variability in CDP-SOT scores (R
2 = 0.46; P = .003), as did fatigue depression and PTSD symptoms (R
2 = 0.33; P = .01).

Conclusions:
Impaired balance was identified among the cohort. Findings suggest that dizziness, fatigue, depression and PTSD, and time since most recent mTBI may influence balance performance. Additional research is needed to identify the potentially interrelated natural histories of these co-occurring symptoms.
The Interaction of Genetic Predisposition and Socioeconomic Position With Type 2 Diabetes Mellitus: Cross-Sectional and Longitudinal Analyses From the Lifelines Cohort and Biobank Study
Authors: van Zon Sander K.R. , Reijneveld Sijmen A. , van der Most Peter J. , Swertz Morris A. , Bültmann Ute , Snieder Harold 
Published: January 2018

ABSTRACT

Objective
A strong genetic predisposition for type 2 diabetes mellitus (T2DM) may aggravate the negative effects of low socioeconomic position (SEP) in the etiology of the disorder. This study aimed to examine cross-sectional and longitudinal associations and interactions of a genetic risk score (GRS) and SEP with T2DM and to investigate whether clinical and behavioral risk factors can explain these associations and interactions.

Methods
We used data from 13,027 genotyped participants from the Lifelines study. The GRS was based on single-nucleotide polymorphisms genome-wide associated with T2DM and was categorized into tertiles. SEP was measured as educational level. T2DM was based on biological markers, recorded medication use, and self-reports. Cross-sectional and longitudinal associations and interactions between the GRS and SEP on T2DM were examined.

Results
The combination of a high GRS and low SEP had the strongest association with T2DM in cross-sectional (odds ratio = 3.84, 95% confidence interval = 2.28–6.46) and longitudinal analyses (hazard ratio = 2.71, 1.39–5.27), compared with a low GRS and high SEP. Interaction between a high GRS and a low SEP was observed in cross-sectional (relative excess risk due to interaction = 1.85, 0.65–3.05) but not in longitudinal analyses. Clinical and behavioral risk factors mostly explained the observed associations and interactions.

Conclusions
A high GRS combined with a low SEP provides the highest risk for T2DM. These factors also exacerbated each other's impact cross-sectionally but not longitudinally. Preventive measures should target individual and contextual factors of this high-risk group to reduce the risk of T2DM.
Cochlear Implantation in Postmeningitic Deafness
Authors: Tokat Taskin , Catli Tolgahan , Bayrak Feda , Bozkurt Ergul Basaran , Olgun Levent 
Published: January 2018

Purpose:
The aim of this study is to evaluate long-term outcomes of cochlear implantation (CI) in patients with postmeningitic deafness.

Methods:
Twenty-seven patients with severe to profound hearing loss due to bacterial meningitis and received CI were the subjects of this study. Surgical findings and long-term audiological performances were evaluated. Speech perception and speech intelligibility of the implanted patients were evaluated with the categories of auditory performance–II (CAP-II) test and speech intelligibility rating (SIR) test, respectively.

Results:
Eighteen of the 27 patients had received full electrode insertion through the patent cochlear lumen. Remaining 9 patients had varying degrees of ossification throughout the cochlea and needed to be drilled to achieve partial electrode insertion. None of the patients exhibited surgical complication. Scores in both test batteries (CAP-II and SIR) were comparable between patients who received full or partial electrode insertion (P > 0.05).

Conclusion:
Cochlear implantation after postmeningitic deafness has favorable outcomes especially in long term. Although this type of inner ear pathology may require special considerations during surgery, it is a relatively safe procedure.
Three-Dimensional Printed Pediatric Airway Model Improves Novice Learners' Flexible Bronchoscopy Skills With Minimal Direct Teaching From Faculty
Authors: DeBoer Emily M. , Wagner Jennifer , Kroehl Miranda E. , Albietz Joseph , Shandas Robin , Deterding Robin R. , Rustici Matthew J. 
Published: January 2018

Introduction
Training in pediatric flexible bronchoscopy (FB) is predominantly completed on patients. Early trainees are less accurate and slower than experienced bronchoscopists. This report describes the development of a three-dimensional printed airway model and describes how the model was used to teach learners basic FB skills.

Methods
Postgraduate year two (PGY2) pediatric residents completing a 1-month pediatric pulmonology rotation with minimal previous exposure to FB were randomized into a simulation trainee group (n = 18) or a control resident group (n = 9). The simulation group received four 15-minute practice sessions (3 self-directed, 1 with feedback). Participants completed a bronchoscopy assessment on the model at prestudy, poststudy, and delayed (at least 2 months after the rotation) time points. Outcomes were identification of markers located in the six lung areas and completion time.

Results
There was no difference in prestudy scores between groups. In the poststudy assessment, the simulation participants correctly identified more lung area markers (median = 6 vs 1.5, P < 0.001) and were faster (median = 102 vs 600 seconds, P < 0.001). In the delayed assessment, correct marker identification trended toward improvement in the simulation group compared with controls (median = 4 vs 2, P = 0.077).

Conclusions
With 1 hour of practice time, requiring 15 minutes of direct teaching, novice resident bronchoscopists are able to more accurately identify and visualize the five lung lobes and lingula via FB and are able to do so in less time than control residents. This anatomically accurate model could be used to train basic FB skills at a low cost compared with other models.
Targeting the SUMO pathway primes all-trans-retinoic acid-induced differentiation of non promyelocytic Acute Myeloid Leukemias
Authors: Baik Hayeon , Boulanger Mathias , Hosseini Mohsen , Kowalczyk Julie , Zaghdoudi Sonia , Salem Tamara , Sarry Jean-Emmanuel , Hicheri Yosr , Cartron Guillaume , Piechaczyk Marc , Bossis Guillaume 
Published: January 2018

AbstractDifferentiation therapies using All-trans-retinoic acid (ATRA) are highly efficient at treating Acute Promyelocytic Leukemia (APL), a minor subtype of Acute Myeloid Leukemias (AML). However, their efficacy, if any, is very limited in the case of non-APL AMLs. We report here that the inhibition of SUMOylation, a post-translational modification related to ubiquitinylation, restores the pro-differentiation and anti-proliferative activities of retinoids in non-APL AMLs. Controlled inhibition of SUMOylation with pharmacological inhibitors (2-D08 or anacardic acid), orviaoverexpression of SENP desumoylases, strongly enhances the ATRA-induced expression of key genes involved in differentiation, proliferation and apoptosis in non-APL AML cells. This activates ATRA-induced terminal myeloid differentiation and reduces cell proliferation and viability, including in AML cells resistant to chemotherapeutic drugs. Conversely, enhancement of SUMOylation by overexpressing the SUMO-conjugating enzyme Ubc9 dampens the expression of ATRA-responsive genes and prevents differentiation. Thus, inhibition of the SUMO pathway is a promising strategy to sensitize non-APL AML patients to retinoids and improve the treatment of this poor prognosis cancer, which has not significantly changed over the past 40 years.
Identification and comparison of individual chromosomes of threeHordeum chilenseaccessions,Hordeum vulgareandTriticum aestivumby FISH
Authors: Rey María-Dolores , Moore Graham , Martín Azahara C. 
Published: January 2018

AbstractKaryotypes of three accessions ofHordeum chilense(H1, H16 and H7),Hordeum vulgareandTriticum aestivumwere characterized by physical mapping of several repetitive sequences. A total of fourteen repetitive sequences were used as probes for fluorescence in situ hybridization (FISH) with the aim of identifying inter‐ and intra-species polymorphisms. The (AG)12and 4P6 probes only produced hybridization signals in wheat, the BAC7 probe only hybridized to the centromeric region ofH. vulgare, and the pSc119.2 probe hybridized to both wheat andH. chilense, but not toH. vulgare. The remaining repetitive sequences used in this study produced a hybridization signal in all the genotypes. Probes pAs1, pTa535, pTa71, CCS1 and CRW were much conserved, showing no significant polymorphism among the genotypes studied. Probes GAA, (AAC)5, (CTA)5, HvT01 and pTa794 produced the most different hybridization pattern. We identified large polymorphisms in the three accessions ofH. chilensestudied, supporting the proposal of the existence of different groups insideH. chilensespecies. The set of probes described in this work allowed the identification of every single chromosome in all three species, providing a complete cytogenetic karyotype ofH. chilense, H. vulgareandT. aestivumchromosomes, useful in wheat and tritordeum breeding programs.
Help thine enemy: the evolution of short ranging signals
Authors: Számadó Szabolcs 
Published: January 2018

AbstractThe proximity risk model offers one possible explanation of honest signalling of aggressive intent in biology. This model assumes that the probability of successful attack is a function of the distance between the contestants and that this distance can be correctly estimated. This later assumption may not hold in nature where contestants have to estimate this distance under noisy conditions. Here I investigate with the help of a game theoretical model whether short-range ranging signals can be evolutionarily stable under such conditions. These signals can help the opponent to estimate the correct distance, thus they can promote honest signalling of intentions. Here I show that ranging signals that help the estimation of distance between opponents can be evolutionarily stable. However, such help only benefits those individuals who are able and willing to attack. As a result, ranging signals in themselves are an honest cue of proximity and in turn they are honest cues of aggressive intent. I give an example: “soft-song” in birds, and I discuss the predictions of the model.
When metabolism meets physiology: Harvey and Harvetta
Authors: Thiele Ines , Sahoo Swagatika , Heinken Almut , Heirendt Laurent , Aurich Maike K. , Noronha Alberto , Fleming Ronan M.T. 
Published: January 2018

AbstractPrecision medicine is an emerging paradigm that requires realistic, mechanistic models capturing the complexity of the human body. We present two comprehensive molecular to physiological-level, gender-specific whole-body metabolism (WBM) reconstructions, named Harvey, in recognition of William Harvey, and Harvetta. These validated, knowledge-based WBM reconstructions capture the metabolism of 20 organs, six sex organs, six blood cells, the gastrointestinal lumen, systemic blood circulation, and the blood-brain barrier. They represent 99% of the human body weight, when excluding the weight of the skeleton. Harvey and Harvetta can be parameterized based on physiological, dietary, and omics data. They correctly predict inter-organ metabolic cycles, basal metabolic rates, and energy use. We demonstrate the integration of microbiome data thereby allowing the assessment of individual-specific, organ-level modulation of host metabolism by the gut microbiota. The WBM reconstructions and the individual organ reconstructions are available underhttp://vmh.life. Harvey and Harvetta represent a pivotal step towards virtual physiological humans.
Kinetics of winter deacclimation in response to temperature determines dormancy status and explains budbreak in differentVitisspecies
Authors: Kovaleski Alisson P. , Reisch Bruce I. , Londo Jason P. 
Published: January 2018

2.AbstractBud dormancy and cold hardiness are critical adaptations for surviving winter cold stress for temperate perennial plant species, with shifting temperature-based responses during the winter. The objective of this study was to uncover the relationship between dormancy transition (chilling requirement) and temperature on the loss of cold hardiness and budbreak. Dormant cuttings ofVitis vinifera,V. aestivalis,V. amurensis, andV. ripariawere examined to determine the relationship between chilling requirement and temperature on rate of deacclimation (kdeacc). Differential thermal analysis was used to determinekdeaccusing mean low temperature exotherms. Effect of chill was evaluated as the deacclimation potential (ψdeacc), which was the change inkdeaccdue to chill accumulation. Budbreak was also evaluated in fully chilled buds at different temperatures. Results indicate that ψdeaccvaries dependent on dormancy state, following a logarithmic response to chill accumulation. The effect of temperature onkdeaccwas exponential at low and logarithmic at high temperatures. The combination of ψdeaccandkdeaccresulted in good prediction of deacclimation. Budbreak phenology was also explained by differences inkdeacc. Deacclimation rates can be used as a quantitative determinant of dormancy transition and budbreak, and to refine models predicting effects of climate change.
Social rewards: the basis for collaboration in honor cultures
Authors: Ramirez-Marin Jimena Yolanda , Shafa Saïd 
Published: January 2018

Purpose
The purpose of this paper is twofold: first, to define social rewards, as acts and expressions which specifically signal respect, courtesy and benevolence to the other party, based on cultural scripts found in honor cultures. Second, to explore whether social rewards mitigate competitive aspirations and foster collaboration in competitive settings, with honor values being a culturally relevant mechanism for this effect.

Design/methodology/approach
This paper reports on two experiments assessing high-honor and low-honor culture participants’ aspirations and behavioral decisions. In study 1, participants described a personal situation where they were praised by close others (social reward) or praised themselves (control condition), before responding to a buyer/seller negotiation scenario. In study 2, participants were either complimented (social reward) or not complimented (control condition), before engaging in live competition with a confederate for monetary outcomes.

Findings
Both studies indicate that social rewards diminish competitive aspirations and offers among high-honor culture participants, but not among low-honor culture participants. Results of study 1 indicate that endorsement of honor values mediates this effect. In conclusion, social rewards can improve interactions with members of honor cultures.

Research limitations/implications
These studies advance our understanding of cultural differences in negotiations and provide insight into social rewards as one of the mechanisms necessary to successfully manage intercultural negotiations and collaboration. Future research should address the effect of social rewards on self-worth and empowerment.

Originality/value
This research is the first to shed light on the relevance and importance of social rewards as a device to facilitate social interactions in honor cultures.
A novel bearing-assisted TDOA-GROA approach for passive source localization
Authors: Luo Ji-An , Tan Zhi-Wen , Peng Dong-Liang 
Published: January 2018

Purpose
The passive source localization (PSL) problem using angles of arrival (AOA), time differences of arrival (TDOA) or gain ratios of arrival (GROA) is generally nonlinear and nontrival. In this research, the purpose of this paper is to design an accurate hybrid source localization approach to solve the PSL problem. The inspiration is drawn from the fact that the bearings, TDOAs and GROAs are complementary in terms of their geometry properties.

Design/methodology/approach
The maximum-likelihood (ML) method is reexamined by using hybrid measurements. Being assisted by the bearings, a new hybrid weighted least-squares (WLS) method is then proposed by jointly utilizing the bearing, TDOA and GROA measurements.

Findings
Theoretical performance analysis illustrates that the mean-square error of the ML or WLS method can attain the Cramér-Rao lower bound for Gaussian noise over small error region. However, the WLS method has much lower computational complexity than the ML algorithm. Compared with the AOA-only, TDOA-only, AOA-TDOA, TDOA-GROA methods, the localization accuracy can be greatly improved by combining the AOAs, TDOAs and GROAs, especially for some specific geometries.

Originality/value
A novel bearing-assisted TDOA-GROA method is proposed for source localization, and a new hybrid WLS estimator is presented inspired from the fact that the bearings, TDOAs and GROAs are complementary in terms of their geometry properties.
Value-at-risk and related measures for the Bitcoin
Authors: Stavroyiannis Stavros 
Published: January 2018

Purpose
The purpose of this paper is to examine the value-at-risk and related measures for the Bitcoin and to compare the findings with Standard and Poor’s SP500 Index, and the gold spot price time series.

Design/methodology/approach
A GJR-GARCH model has been implemented, in which the residuals follow the standardized Pearson type-IV distribution. A large variety of value-at-risk measures and backtesting criteria are implemented.

Findings
Bitcoin is a highly volatile currency violating the value-at-risk measures more than the other assets. With respect to the Basel Committee on Banking Supervision Accords, a Bitcoin investor is subjected to higher capital requirements and capital allocation ratio.

Practical implications
The risk of an investor holding Bitcoins is measured and quantified via the regulatory framework practices.

Originality/value
This paper is the first comprehensive approach to the risk properties of Bitcoin.