bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Trabectedin in Patients with Advanced Translocation-Related Sarcomas: Pooled Analysis of Two Phase II Studies
Authors: Takahashi Mitsuru , Takahashi Shunji , Araki Nobuhito , Sugiura Hideshi , Ueda Takafumi , Yonemoto Tsukasa , Morioka Hideo , Hiraga Hiroaki , Hiruma Toru , Kunisada Toshiyuki , Matsumine Akihiko , Shimura Masashi , Kawai Akira 
Published: May 2017

Abstract

Background
Trabectedin is reported as effective, especially against translocation-related sarcomas (TRSs) after failure of or intolerance to standard chemotherapy. We conducted two phase II studies of TRS, confirming high efficacy of 1.2 mg/m2 trabectedin. The updated data of 66 patients in these studies was integrated to evaluate the efficacy of trabectedin against each histological subtype, and analyze final overall survival (OS).

Methods
Trabectedin was administered on day one of a 21-day cycle. Efficacy was assessed using progression-free survival (PFS), OS, and best overall response. An analysis of OS and PFS was performed for subgroups divided by baseline lymphocyte count (&lt;1,000/μL, ≥1,000/μL) or number of previous chemotherapy regimens (0, 1, 2, ≥3 regimens), and a Weibull parametric model was used to estimate the numerical relationship between lymphocyte count and PFS and OS.

Results
Median PFS and OS in overall patients were 5.6 (95% confidence interval [CI]: 4.1–7.3) and 17.5 months (95% CI: 12.6–23.6), respectively. PFS in the myxoid and round-cell liposarcoma (MRCL) group (7.4 months [95% CI: 5.6–11.1]) was longer than in the other subtypes. The response rate was also highest in the MRCL group. Median OS was longer in patients with baseline lymphocyte counts ≥1,000/μL than in those with counts of &lt;1,000/μL, but median PFS was not different between the two subgroups.

Conclusion
Our updated and pooled data showed that trabectedin exerted prolonged disease control and antitumor effects in patients with advanced TRS, especially in MRCL. We consider that the subgroup analyses also provide important information for trabectedin treatment in patients with TRS.
p16, HPV, and Cetuximab: What Is the Evidence?
Authors: Bonner James A. , Mesia Ricard , Giralt Jordi , Psyrri Amanda , Keilholz Ulrich , Rosenthal David I. , Beier Frank , Schulten Jeltje , Vermorken Jan B. 
Published: May 2017

Abstract
Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common cancer worldwide. It has recently been appreciated that human papillomavirus (HPV) status (or p16 status, which is a frequently used surrogate for HPV status) is prognostic for oropharyngeal SCCHN. Here, we review and contextualize existing p16 and HPV data, focusing on the cetuximab registration trials in previously untreated, locoregionally advanced, nonmetastatic SCCHN (LA SCCHN) and in recurrent and/or metastatic SCCHN (R/M SCCHN): the IMCL-9815 and EXTREME clinical trials, respectively. Taken together, the available data suggest that, while p16 and HPV are prognostic biomarkers in patients with LA SCCHN and R/M SCCHN, it could not be shown that they are predictive for the outcomes of the described cetuximab-containing trial regimens. Consequently, although HPV status provides prognostic information, it is not shown to predict therapy response, and so is not helpful for assigning first-line therapy in patients with SCCHN. In addition, we discuss assays currently used to assess p16 and HPV status, as well as the differentiation between these two biomarkers. Ultimately, we believe HPV E6/E7 polymerase chain reaction–based mRNA testing may represent the most informative technique for assessing HPV status in patients with SCCHN. While p16 is a valid surrogate for HPV status in oropharyngeal carcinoma (OPC), there is a higher risk of discordance between p16 and HPV status in non-OPC SCCHN. Collectively, these discussions hold key implications for the clinical management of SCCHN.
Management of Treatment-Related Adverse Events with Agents Targeting the MAPK Pathway in Patients with Metastatic Melanoma
Authors: Daud Adil , Tsai Katy 
Published: May 2017

Abstract
Tremendous progress has been made in the clinical landscape of advanced-stage BRAF V600–mutant melanoma treatment over the past 5 years. Targeted therapies that inhibit specific steps of the mitogen-activated protein kinase pathway have been shown to provide significant overall treatment benefit in patients with this difficult-to-treat disease. Combination therapy with BRAF and MEK inhibitors (dabrafenib plus trametinib or vemurafenib plus cobimetinib, respectively) has become standard of care. These agents are administered until disease progression or unacceptable toxicity occurs; thus, some patients may remain on maintenance therapy for an extended period of time, while toxicities may result in early discontinuation in other patients. Because the goal of treatment is to prolong survival with minimal impairment of quality of life, drug-related adverse events (AEs) require prompt management to ensure that patients derive the best possible benefit from therapy. Proper management depends on an understanding of which AEs are most likely BRAF or MEK inhibitor associated, thus providing a rationale for dose modification of the appropriate drug. Additionally, the unique safety profile of the chosen regimen may influence patient selection and monitoring. This review discusses the toxicity profiles of these agents, with a focus on the most commonly reported and serious AEs. Here, we offer practical guidance derived from our clinical experience for the optimal management of key drug-related AEs.
PERDAS E IMPUREZAS NA COLHEITA MECANIZADA DE CANA-DE-AÇUCAR UTILIZANDO DIFERENTES CONFIGURAÇÕES DE TRABALHO DA COLHEDORA
Authors: Guedes Ramos Carlos Renato , Lanças Kléber Pereira , Santos Ronilson de Souza , Silva Romulo Leonardo da 
Published: May 2017

A colheita mecanizada de cana-de-açúcar tem apresentado deficiências em qualidade da matéria-prima colhida em função das condições encontradas no canavial e da falta de regulagem apropriada das colhedoras. A quantidade de impurezas junto à carga e a redução das perdas de matéria-prima podem ser minimizadas a partir do investimento em treinamento para operadores. O trabalho teve por objetivo avaliar a qualidade da colheita mecanizada da cana-de-açúcar em função da sua velocidade de deslocamento, rotação do extrator primário da colhedora e produtividade agrícola do canavial. Como tratamentos, foram selecionadas duas velocidades de deslocamento para a colhedora, sendo uma velocidade padrão de colheita e a máxima velocidade alcançada. Foram utilizadas três diferentes rotações do extrator primário da colhedora: baixa, intermediária e alta. Além disso, o experimento foi realizado em duas áreas com produtividade agrícola distintas, sendo uma de baixa e a outra de alta produtividade. Foram avaliadas as perdas visíveis de matéria-prima e o índice de impurezas vegetais eminerais presentes na matéria-prima colhida. As perdas de matéria-prima foram influenciadas pelo aumento da velocidade de deslocamento da colhedora e podem ser menores em áreas de alta produtividade agrícola do que em áreas com menor produtividade agrícola, quando analisadas em percentual. O aumento da velocidade de colheita causou aumento na presença de impurezas vegetais e minerais. Observou-se que a eficiência de extração de impurezas vegetais foi melhor na área de alta produtividade agrícola do que na área de baixa produtividade.
Analysis of treatment outcome in multi-drug resistant tuberculosis patients treated under programmatic conditions
Authors: Janmeja A. K. , Aggarwal Deepak , Dhillon Ruchika 
Published: May 2017

Background: Programmatic management of MDR-TB has taken over the un-standardized and unsupervised treatment practice in India. However, despite being implemented in whole of country, the data on the program surveillance is scarce. Hence the present study was sought to evaluate the treatment outcome in patients with MDR TB in Chandigarh being treated under programmatic conditions.Methods: A retrospective study was carried out by enrolling all MDR-TB patients registered between January 2012 to December 2014. Medical records of 140 patients were scrutinized for necessary information on demographic, clinical parameters and previous TB treatment. Treatment outcomes to Cat IV anti-TB therapy, any interruptions in treatment, adverse drug reactions, culture conversion etc. were evaluated from the records.Results: Of the 140 patients, 77 (55%) were declared cured, 11 (7.9%) completed treatment, 23 patients (16.4%) died, 13 (9.3%) defaulted on treatment, 5 (3.6%) had treatment failure and 11 (7.9%) were shifted to Cat V therapy. On comparison, BMI, haemoglobin, treatment outcome in previous ATT, treatment adherence and time to sputum culture conversion were significantly different in different treatment outcome groups.Conclusions: The treatment success rate of MDR‑TB patients have shown improvement under programmatic conditions. Interventions to improve BMI and treatment adherence might further help to improve the success rate.
Foreign bodies in aero-digestive tract in children: spectrum of presentation and management
Authors: Patil Rajashekhar T. , Prakash Advait 
Published: May 2017

Background: Foreign body (FB) ingestion and aspiration is quite common in children. It can be a life-threatening condition. Early diagnosis of foreign body aspiration is essential as delay in its recognition and treatment results in high morbidity and mortality. Symptoms seem to mostly depend on the anatomical location. The absence of specific symptoms indicating the occurrence of FB injury can lead to delay in diagnosis, thereby increasing the risk of complications.Methods: This is a prospective study which comprised of 50 patients with between 8 months and 4.5 years. FB involving different parts of the aero-digestive tract were included in the study. The site, side, symptoms and radiographic findings were recorded for each patient. Different procedures were used for retrieval of various FB at different locations. Majority of these procedures were performed under anaesthesia.Results: Most of the FB were organic in nature. Right side bronchus was more commonly involved. A combination of different procedures was used according to the site involved. All the FB were removed successfully and smoothly. There was minimum morbidity with no mortality and the overall outcome was excellent. Hospital stay varied according to the site of involvement.Conclusions: The symptoms of FB change with the site involved and many patients are even asymptomatic. A differential diagnosis of foreign body should always be made in an acute or chronic presentation of respiratory cases. Aspiration of foreign body should be suspected in all cases of broncho-pulmonary infection with atypical course. High index of suspicion is the cornerstone of diagnosis. Bronchoscopy is the best diagnostic and therapeutic method in all suspicions of foreign body of tracheo-bronchial tree. Proper and timely intervention optimizes the outcome.
Factors influencing perforated appendicitis in a tertiary care hospital
Authors: A. Palachandra , R. Shashank , C. Y. Sreelatha 
Published: May 2017

Background: Appendicitis is among the most common abdominal conditions requiring admission to emergency surgery departments. It has a life time risk of 6%. Untreated appendicitis may be complicated with development of gangrene or perforation, resulting in high morbidity and mortality rates in almost all age groups. The frequency of appendicitis may show variation by population, age, sex, socioeconomic status, and race. The objective of this study was to know the influence of some demographic factors on perforated appendicitis in a tertiary care hospital.Methods: A descriptive cross sectional was done in a teaching hospital which is a referral center. All the acute appendicitis cases admitted to the hospital between January 2015 to December 2016 were included in the study. A total of 532 acute appendicitis cases were diagnosed based on pathological features and were allocated to either the perforated or non-perforated appendicitis groups.Results: In our study total 532 cases were operated for appendicitis. Among that 294 (56%) were males and 238 (44%) were females with a ratio of 1.27:1.00. The mean age was 26.8±13.2 among non -perforated cases and 22.4±12.3 among perforated cases. In present study, maximum cases were in the age group 21-30 years and perforation was more among >50 years age group (23.3%).Conclusions: Perforation was higher among >50 years age group and in the patients from rural area which was found to be statistically significant. The reasons can be misdiagnosis, delayed diagnosis, financial and transportation problems.
Urinary incontinence: prevalence, risk factors, impact on quality of life and treatment seeking behaviour among middle aged women
Authors: Agarwal Brijesh Kumar , Agarwal Namita 
Published: May 2017

Background: Urinary incontinence (UI) is one of the priority health issue recognized by WHO. Urinary incontinence (UI) is defined by the international continence society as "a condition in which involuntary loss of urine is objectively demonstrable and is a social and hygiene problem. It is a common and distressing medical condition severely affecting quality of life (QOL). Urinary incontinence is a common health problem among women, with the prevalence varying from 8-45% in different studies.Methods: This study was based among the population around SRM-IMS, Bareilly. Total 464 women were interviewed out of 2860 total inhabitants.Results: Out of 464, 236 females were selected for this study. 28 women had urinary incontinence. The overall prevalence of urinary incontinence in our study was about 12%. There was significant association of increasing age and presence of urinary incontinence. Urinary incontinence does impact on quality of life of a woman having urinary incontinence. Impact of personal factors do not have much impact on urinary incontinence. 22% women had stress urinary incontinence, 38% had urgency incontinence and 38% had mixed type of urinary incontinence.Conclusions: Various obstetrical factors do contribute to urinary incontinence. Urinary incontinence is a significant health problem in the society leading to restriction in social and sexual activities. Almost 1 in 12 women suffering from urinary incontinence. Simple epidemiological tools such as a questionnaire can unveil the urinary incontinence subjectively. Further efforts are to be done to improve the quality of life and minimizing the urinary incontinence by pursuing them for treatment.
To study hematological profile in malaria patients
Authors: Yadav Rakesh Kumar , Kumar Sujit 
Published: May 2017

Background: Malaria has been a problem in India for centuries and it is responsible for many deaths in rural areas. This study was done to observe hematological profile in malaria patients and to study the incidence of complications in different species of malaria patients and to find any relation with hematological changes.Methods: The study was conducted at MLN Medical College, Allahabad in the Department of Medicine between January 2016 to December 2016. One hundred consecutive patients aged 18 years or more with malaria fever were interviewed and examined.Results: Out of 100 patients 26 patients had Plasmodium vivax malaria and 59 patients had Plasmodium falciparum infection while 15 patients had mixed PV and PF infection. In present study thrombocytopenia was most common hematological abnormality. Thrombocytopenia was present in 87 patients, out of them 18 had very severe thrombocytopenia while 69 had mild to moderate thrombocytopenia. Frank bleeding was present in 14 of total studied population and had both PV and PF infection. Petechial rashes were present in 10 patients. Anemia was present in 80 patients.Conclusions: Thrombocytopenia is very frequent finding in patients suffering from malaria, and even in presence of thrombocytopenia bleeding manifestations are uncommon. So, platelet transfusion should not be performed routinely in all thrombocytopenia patients, rather it should be indicated only if bleeding manifestations are present. Anemia, pancytopenia and leucopenia are other frequent laboratory findings of malaria infection.
Ozone discolysis in lumbar disc prolapse
Authors: Charan Rajat , Runu Ritesh , Kumar Animesh , Chauhan Himanshu 
Published: May 2017

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Treatment of low back ache due to prolapsed intervertebral disc is still controversial. Several conservative modalities are available with varied results. Surgical discectomy may lead to failed back syndrome due to change in vertebral column anatomy and its mechanics. To prevent it, conservative means are better and Ozone discolysis is one of the nonsurgical methods. The indications and effectiveness of this condition is not well defined. The present study was done to correlate the clinical outcome of this technique.</span></p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">This was a prospective study conducted on 67 patients presenting with symptoms of back pain with arid without radicular symptoms. X ray and MRI were done in all cases. Then intradiscal ozone gas was given at one level from a specialized machine under C arm guidance. For evaluation Oswestry disability index and Macnab scoring system was used. Post injection patients were evaluated at 2, 6 weeks and 6 months</span>.<strong></strong></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Sixty seven patients with mean age of 47.7 years were followed up for 7.8 months. Low back pain was the commonest symptom and SLR was positive in 5.36%. The modified Macnab scoring with good and fair score improved from 16% to 89% and Oswestry disability index with minimal and moderate disability improved from 41% to 91% at end of 6 months. Seven patients had relapse of pain due to repeat disc prolapse. </span></p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Ozone discloses is better modality of treatment for low back pain with disc bulge and early disc prolapsed.</span></p><p class="abstract"> </p>
Ethno-Religious Pluralism and Sustainable National Development: The Nigeria Experience
Authors: Eneji C.V.O. , Ntamu G.U. , Asor Love Joseph 
Published: May 2017

<p>Ethno-religious pluralism and sustainable national development in Nigeria seem a paradox as well as an unattainable goal. Lives and properties have been wantonly destroyed with unabated zeal without due consideration to our common humanity. Resources that would have lifted the poor and underprivileged to higher levels of existence are regularly wasted in restoring damaged infrastructures. The Nigerian experience appears bleak without any hope in the horizon. This paper examines how these serious but intangible phenomena have bedeviled Nigeria as a nation. The study was carried out in sixteen Nigerian Universities. The research sample was made up of 800 lecturers from sixteen Nigerian University divided into north and south. The sampling technique adopted was the multi staged random sampling technique; data was collected through the use of structured questionnaire administered directly by the researchers and 10 research assistants over a period of 3 months. Two research questions and two hypotheses were designed to guide the study. After coding the data generated from the field using the research instrument, data was subjected to independent t-test analysis. Results obtained show that Muslim staff religious tolerance (15.9&gt;8.2); this produced t-value of 33.9 with a p-value higher than the .05 significance level with 798 degree of freedom, this implies that religious tolerance does significantly influence sustainable national development. The result of the second hypothesis also shows that mean score for north is slightly greater than the mean score for south (11.86&gt;10.73); this produced t-value of 2.41with a p-value higher than the .05 significance level with 798 degree of freedom. This implies ethnocentrism (religious pluralism and ethnicity) has significant influence on sustainable national development in Nigeria. The authors concluded that despite the religious pluralism as is observed in Nigeria, Nigerians can still live peacefully among the different ethnic nationalities and carry out sustainable national development. It was however recommended that leaders should make their followers understand that Nigeria is a country for all of us and as such every citizen has equal rights and privileged to govern or lead and every leader should give equal opportunities to every sector of the country.</p>
The Influence of Job demand On Burnout with Job Resource and Personal Resource as moderator: Study on PT Kusumaputra Santosa Karanganyar
Authors: Oktarina Ardianti Nur , Harsono Mugi 
Published: May 2017

The aim of this research was to analyse the effect of job demand on burnout and to analyse the moderators (job resource and personal resource) effect on the relationship between job demand and burnout. This research used quantitative research method with 232 peoples sample respondents. Data analysis techniques were using multiple linear regression and MRA (Moderating Regression Analysis) to determine the effect of moderators. The results of this research are follows: 1) Job demand has a significant positive effect on burnout, and tested on every Job demand dimensions (Qualitative demand, quantitative demand, and organizational demand) positively affects burnout significantly. 2) Job resources become moderation predictor of job demand on burnout. Meanwhile, when tested on every dimension of job demand (Qualitative demand, quantitative demand, organizational demand), then can be concluded Job resource becomes <em>moderation quasi</em> in qualitative demand on burnout, and job resource becomes moderation predictor in quantitative demand on burnout, job resource becomes moderation predictor in organizational demand on burnout. 3) Personal resources become moderation predictor between job demand on burnout. Meanwhile, when tested on every dimension of job demand (Qualitative demand, quantitative demand, organizational demand), then showed Personal Resource becomes <em>moderation quasi</em> on qualitative demand on burnout, and Personal resource becomes moderation predictor in quantitative demand on burnout, Personal resource becomes moderation predictor in organizational demand on burnout.
Gestión participativa en la elaboración de estrategias de revitalización urbana para el Barrio histórico de San José, Puebla
Authors: Ramírez Rosete Norma Leticia , Calderón Calderón Basilio , Milián Ávila María Guadalupe , Guevara Romero María Lourdes 
Published: May 2017

La necesidad de incidir en la forma de intervenir el Centro Histórico de Puebla para mejorar las condiciones de habitabilidad y cohesión social del barrio de San José, nos conlleva a construir una propuesta metodológica de alcance multidisciplinario que sea un modelo de intervención. De esta manera, se deberán analizar las políticas, estrategias y el impacto generado por los proyectos de rehabilitación urbana implementados por el gobierno en el Centro Histórico y, principalmente, enfatizar el papel de la participación de la comunidad en la protección, rescate y conservación de sus barrios. Esta preocupación investigativa nos conduce a la reflexión teórica y al estudio del arte de la rehabilitación urbana sostenible —de gran relevancia en el ámbito internacional— y da la pauta para analizar la viabilidad de diferentes tipos de intervención (conservación, renovación, regeneración, etc.) realizados de manera parcial y fragmentada a principios del siglo XX. Resultado de esas intervenciones es la formulación de un modelo integral de rehabilitación urbana sostenible como principal acción de mejoramiento, capaz de recuperar estos espacios históricos en los ámbitos social, cultural, económico, urbano y ambiental. En este sentido, la gestión participativa coadyuvará a fortalecer la propuesta de estrategias de rehabilitación a escala de barrio que garantice la integración social y la mejora de la calidad de vida en el barrio de San José.