bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative Analysis of Parental Observations on Quality of Life in Australian Children with Down Syndrome
Authors: Murphy Nada , Epstein Amy , Leonard Helen , Davis Elise , Reddihough Dinah , Whitehouse Andrew , Jacoby Peter , Bourke Jenny , Williams Katrina , Downs Jenny 
Published: January 2017

ABSTRACT:

Objective:
There are many challenges to health, functioning, and participation for children with Down syndrome; yet, the quality-of-life (QOL) domains important for this group have never been clearly articulated. This study investigated parental observations to identify QOL domains in children with Down syndrome and determined whether domains differed between children and adolescents.

Methods:
The sample comprised 17 families whose child with Down syndrome was aged 6 to 18 years. Primary caregivers took part in semistructured telephone interviews to explore aspects of their child's life that were satisfying or challenging. Qualitative thematic analysis was implemented using a grounded theory framework to identify domains. The coded data set was divided into 2 groups (childhood and adolescence) at 3 age cut points to observe whether differences existed between the coded domains and domain elements: (1) 6 to 11 years with 12 to 18 years; (2) 6 to 13 years with 14 to 18 years; and (3) 6 to 15 years with 16 to 18 years.

Results:
Eleven domains were identified: physical health, behavior and emotion, personal value, communication, movement and physical activity, routines and predictability, independence and autonomy, social connectedness and relationships, variety of activities, nature and outdoors, and access to services. No differences in domains and domain elements were identified across childhood and adolescence.

Conclusion:
Our data form a preliminary framework from which to design investigations of the child's perspectives on life quality and suggest a range of necessary supports and services.
Arcanobacterium haemolyticum Central Nervous System Abscess and Bacteremia Following Head Trauma
Authors: Cortés-Penfield Nicolás , Kohli Anjali , Weatherhead Jill , El Sahly Hana 
Published: January 2017

Abstract

Arcanobacterium haemolyticum is an uncommon cause of pharyngitis with rash that occurs predominantly among adolescents and that has been only rarely implicated in severe or systemic infections. We report a case of subdural empyema and bacteremia due to A. haemolyticum in a female adolescent following physical assault with trauma to the head, which required neurosurgical intervention combined with prolonged antibiotic therapy. In addition, we describe the previous occurrences of A. haemolyticum culture positivity recorded over a 15-year period by the microbiology laboratories of the 2 large academic medical centers at which this patient received care and review the epidemiology, laboratory identification, and treatment of this unusual pathogen.
Challenges and opportunities to enhance global drug development in neonates
Authors: Smith Alexandra M. , Davis Jonathan M. 
Published: January 2017

Purpose of review
This study reviews the history of neonatal drug development, recent legislative efforts designed to facilitate the study of therapeutic agents in neonates, and future steps necessary to advance drug development.

Recent findings
Although many federal regulations have been introduced over the past 15 years to encourage pediatric and neonatal drug development, the majority of medications that are used in the Neonatal Intensive Care Unit are not approved by the Food and Drug Administration (FDA) for use in neonates. There are many challenges that investigators encounter in conducting neonatal clinical trials. The Critical Path Institute working in conjunction with the FDA has developed several consortia, including the International Neonatal Consortium and Pediatric Trials Consortium, to address these concerns and facilitate interactions of researchers, regulators, funding agencies, industry, and others across the globe to produce regulatory ready and high quality data for neonatal therapeutics.

Summary
Neonatal drug development is an area which deserves significant attention if we hope to continue to improve outcomes. With the help of international collaborations, it is possible to accelerate efficient and high quality neonatal research through multidisciplinary teams that share data, knowledge, and expertise to advance medical innovation and regulatory science.
Basal Ganglion Hemorrhage as Delayed Complication of Diethylene Glycol Ingestion
Authors: Gupta Avneesh , Diaz Francisco J. , Lal Anita , Sung Lokman , Aaron Cynthia K. 
Published: January 2017

Abstract
Diethylene glycol (DEG), an organic compound (HOCH2CH2)2O is a commonly used solvent. Mass poisoning outbreaks have been reported because of frequent contaminations. A PubMed search for diethylene resulted in 795 publications with 151 specifically discussing the toxicity. Of the 151 reported toxicity reviews/case reports, only 6 publications discussed the long-term neurological effects of diethylene toxicity. We report a fatal case of oral ingestion of DEG with complications from delayed toxicity. She died 7 days after the second admission. Autopsy disclosed a right basal ganglia hemorrhage within the brain and microscopic deposits of polarizable crystals into small cerebral blood vessels. Both kidneys illustrate tubular necrosis with scattered tubular deposition of polarizable calcium oxalate crystals. PubMed search leads to only 2 reported cases of basal ganglia hemorrhage (based on radiological findings) after ethylene glycol intoxication. Our case is the first reportable case of basal ganglia hemorrhage after DEG ingestion.
Prediction of Anastomotic Leakage After Laparoscopic Low Anterior Resection in Male Rectal Cancer by Pelvic Measurement in Magnetic Resonance Imaging
Authors: Tsuruta Atsushi , Tashiro Jo , Ishii Toshimasa , Oka Yasuo , Suzuki Asami , Kondo Hiroka , Yamaguchi Shigeki 
Published: January 2017

Objective:
Anastomotic leakage after laparoscopic low anterior resection in male rectal cancer patients with a narrow pelvis cannot be easily resolved. The objective of this study is to assess numerical information of narrow pelvis and to determine whether prediction of morbidity can be possible.

Methods:
Retrospective medical record review was performed. From July 2007 to January 2013, 43 consecutive male patients with low rectal cancer who underwent laparoscopic low anterior resection were divided into the anastomotic leakage–negative group and anastomotic leakage–positive group. Eleven anatomic parameters were measured from preoperative magnetic resonance imaging of pelvis and a new index called “pelvic index” was calculated.

Results:
The pelvic index (difference between the interspinous distance and the diameter of the mesorectum divided by the depth of the cavity of the lesser pelvis) in the leakage-positive group was significantly smaller than that in the negative group (P=0.038). Comparison between those 2 groups at the border of the cut-off value of the pelvic index (13.0) showed a significant difference.

Conclusions:
Preoperative assessment by the pelvic index can predict the narrow pelvis and risk of anastomotic leakage.
Ancient antagonism between CELF and RBFOX families tunes mRNA splicing outcomes
Authors: Gazzara Matthew R , Mallory Michael J. , Roytenberg Renat , Lindberg John , Jha Anupama , Lynch Kristen W. , Barash Yoseph 
Published: January 2017

ABSTRACTOver 95% of human multi-exon genes undergo alternative splicing, a process important in normal development and often dysregulated in disease. We sought to analyze the global splicing regulatory network of CELF2 in human T cells, a well-studied splicing regulator critical to T cell development and function. By integrating high-throughput sequencing data for binding and splicing quantification with sequence features and probabilistic splicing code models, we find evidence of splicing antagonism between CELF2 and the RBFOX family of splicing factors. We validate this functional antagonism through knockdown and overexpression experiments in human cells and find CELF2 represses RBFOX2 mRNA and protein levels. Because both families of proteins have been implicated in the development and maintenance of neuronal, muscle, and heart tissues, we analyzed publicly available data in these systems. Our analysis suggests global, antagonistic co-regulation of splicing by the CELF and RBFOX proteins in mouse muscle and heart in several physiologically relevant targets including proteins involved in calcium signaling and members of the MEF2 family of transcription factors. Importantly, a number of these co-regulated events are aberrantly spliced in mouse models and human patients with diseases that affect these tissues including heart failure, diabetes, or myotonic dystrophy. Finally, analysis of exons regulated by ancient CELF family homologs in chicken, andDrosophilasuggests this antagonism is conserved through evolution.
Lift offset: an analytical insight
Authors: Rand Omri , Khromov Vladimir 
Published: January 2017

Purpose
This paper aims to present an analytical insight into the effect known as lift offset. This effect may be of advantage in terms of power consumption when configurations that consists of two main rotors (coaxial, tandem, etc.) are operated at high speed forward flight. Fundamentally, each of the main rotors is producing a roll moment in opposite direction that is overall canceled to allow trim. The first-order phenomena of lift offset are therefore related to the load distribution over each rotor and may be analyzed independently of the interaction between the rotors.

Design/methodology/approach
Using simple analytical model, this paper analytically and explicitly evaluates the lift offset effect. It also demonstrates in a closed analytical form the various phenomena involved, including the optimal values obtained.

Findings
The paper shows that the main effect of lift offset is its influence on the lift coefficient distribution over the disk. It is also demonstrated that lift offset substantially reduces both the average and the azimuthal variation of the lift coefficient.

Originality/value
Comparison with numerical predictions shows adequate correlation. Overall, the insight provided may be use as a guideline for advance design of rotorcraft configurations of coaxial/tandem rotor systems.
Superior economic performance in developed and developing countries
Authors: Ruiz Sandra , Arvate Paulo , Xavier Wlamir 
Published: January 2017

Purpose
The extant literature on emerging economies states that the development of the institutional context contributes to the creation of hypercompetitive conditions. The purpose of this paper is to test this assertion by using data from both developing and developed countries.

Design/methodology/approach
The study used a probit model, Kolmogorov Smirnov tests and propensity score matching to determine the difference in persistent superior economic performance. Panel data from 600 firms in 26 different countries were used for the period from 1995 to 2011.

Findings
The empirical results support the proposition that there is a significant difference in superior economic performance and persistent superior economic performance sustainability between firms in developed and developing countries.

Originality/value
This study contributes by fostering other theories related to competitive advantages and giving special emphasis to the comparison between developed and developing countries.
The influence of culture on real earnings management
Authors: Pacheco Paredes Angel Arturo , Wheatley Clark 
Published: January 2017

Purpose
The purpose of this paper is to extend prior literature regarding the interrelationships between national culture and accounting practices.

Design/methodology/approach
Using Hofstede’s (1980) cultural indices, the authors employ hierarchical linear modeling to examine the impact of economic growth (emerging markets), country, and culture on real earnings management (REM) for a sample of firms from 31 countries.

Findings
The results reveal a negative association between REM and Hofstede’s (1980) measures of individualism, masculinity, and uncertainty avoidance, but a positive association with power distance. These results hold even after controlling for discretionary accruals. The results further reveal that measures of investor protection are subsumed by culture.

Research limitations/implications
The findings are limited by the use of Hofstede’s (1980) data. There is, however, a significant body of research that continues to rely on and support the use of Hofstede’s model.

Practical implications
The results should be of significant importance to investors who should consider cultural characteristics when assessing firm reported performance, and should prompt auditors and regulators to apply greater scrutiny to the financial reports in cultures characterized by high levels of power distance, especially given the apparent tradeoffs between accruals and REM.

Social implications
The results reveal that status as an emerging market does not influence managers’ use of REM, and that the strength of a country’s investor protection mechanisms are subsumed by culture. Similarly, accounting systems (e.g. International Financial Reporting Standards), by themselves, do not bring about a convergence of managerial behavior. Rather, investors should consider culture when making decisions regarding capital allocation.

Originality/value
The increasing trend toward economic globalization and accounting harmonization makes the understanding of differences in accounting practices, and the possible impact of national culture on manager’s decisions, more important than ever. This research links REM to cultural values and tests for evidence that national culture, values, and structures of investor protection affect REM in the ways they affect managers’ attitudes toward the management of earnings through accruals.
The data-driven analytics for investigating cargo loss in logistics systems
Authors: Wu Pei-Ju , Chen Mu-Chen , Tsau Chih-Kai 
Published: January 2017

Purpose
Cargo loss has been a major issue in logistics management. However, few studies have tackled the issue of cargo loss severity via business analytics. Hence, the purpose of this paper is to provide guidance about how to retrieve valuable information from logistics data and to develop cargo loss mitigation strategies for logistics risk management.

Design/methodology/approach
This study proposes a research design of business analytics to scrutinize the causes of cargo loss severity.

Findings
The empirical results of the decision tree analytics reveal that transit types, product categories, and shipping destinations are key factors behind cargo loss severity. Furthermore, strategies for cargo loss prevention were developed.

Research limitations/implications
The proposed framework of cargo loss analytics provides a research foundation for logistics risk management.

Practical implications
Companies with logistics data can utilize the proposed business analytics to identify cargo loss factors, while companies without logistics data can employ the proposed cargo loss mitigation strategies in their logistics systems.

Originality/value
This pioneer empirical study scrutinizes the critical cargo loss issues of cargo damage, cargo theft, and cargo liability insurance through exploiting real cargo loss data.
Supply chain 2.0 revisited: a framework for managing volatility-induced risk in the supply chain
Authors: Christopher Martin , Holweg Matthias 
Published: January 2017

PurposeThe purpose of this paper is to provide an update to the Supply Chain Volatility Index (SCVI), and expand on prior work by presenting a conceptual framework illustrating how firms can deal with persistent volatility, the ensuing risk and mitigate the cost implications for their supply chain operations.Design/methodology/approachThe authors use long-term time series of secondary data to assemble a “basket” of key indicators that are relevant to the business context within which global supply chains operate. The authors also report on five years of feedback gained from presentations of the SCVI to scholars and practitioners.FindingsVolatility has reduced from record levels experienced during the global financial crises, yet remains at levels considerably higher than prior to the crisis, with no sign of a return to the more stable conditions that prevailed when many current supply chain networks were designed.Research limitations/implicationsThe authors reaffirm that new mental models are needed which embrace volatility as a factor in supply chain design, rather than seek to eradicate it in supply chain operations. Traditional static “network optimisation” based on a simple definition of low unit cost seems no longer appropriate under conditions of persistent volatility.Practical implicationsThe authors provide a conceptual link of volatility, risk and cost in the supply chain, and outline how firms can develop a supply chain strategy by managing their exposure to volatility.Originality/valueThe authors challenge the common assumption that volatility invariably leads to risk and higher cost in the supply chain. Instead the authors argue that the supply chain structure can mitigate the exposure to supply chain risk. The authors introduce the concepts of recovery and resilience cost within a framework designed to help firms manage volatility-induced risk by minimising the adverse cost implications of volatility in their supply chains.
Do high workload and job insecurity predict workplace bullying after organizational change?
Authors: Spagnoli Paola , Balducci Cristian 
Published: January 2017

Purpose
Organizational change eliciting negative outcomes might play a role in the development of workplace bullying. The purpose of this paper is to examine the direct and the interaction effect of two particular negative outcomes of organizational change, such as high workload and job insecurity, on workplace bullying.

Design/methodology/approach
Participants in the study were 134 Italian workers who had just experienced an organizational change. A multiple regression analysis, using the stepwise method, was conducted to test for whether workload, job insecurity, and their interactions predicted workplace bullying.

Findings
Results show that high level of workload is related to workplace bullying; job insecurity is not directly related to workplace bullying; the interaction between high workload and job insecurity enhanced the risk for workplace bullying. In particular, when the level of job insecurity is high there is a stronger relationship between workload and bullying, compared to when the level of job insecurity is low.

Research limitations/implications
The cross-sectional design applied does not allow inference on the causal relationships between the predictors and outcomes.

Practical implications
In order to decrease the occurrence of bullying, managers should avoid that employees experience high workload after organizational change by carefully designing the reengineering process. Additionally, they should try to reduce, as far as possible, employee perceptions of job insecurity.

Originality/value
The focus of the study is on the “survivors” after organizational change and on particular interaction of workplace bullying’s causes that could extremely enhance the risk of the phenomena.
Factors influencing compliance level with AAOIFI financial accounting standards by Islamic banks
Authors: Mnif Sellami Yosra , Tahari Marwa 
Published: January 2017

Purpose
The purpose of this paper is to investigate the compliance level of Islamic banks with disclosure accounting standards in some Middle East and North African countries, and most importantly to analyse the factors associated with compliance.

Design/methodology/approach
This study uses a self-constructed checklist of 203 items to measure the compliance of 38 Islamic banks with disclosure accounting standards during the 2011-2013 period. A multivariate regression analysis is used to determine significant factors influencing the extent of this compliance.

Findings
The results show a wide variation in compliance levels among the disclosure accounting standards and reveal that compliance is positively related to the listing status, the existence of an audit committee, the bank’s age and the country of domicile.

Research limitations/implications
This study analyses the compliance level with only disclosure accounting standards. It remains to future research to examine compliance with all Accounting and Auditing Organization for Islamic Financial Institutions’ Financial Accounting Standards (AAOIFI FAS). Moreover, the explanatory power of the model remains modest. This connotes the existence of omitted variables that could be explored in future research.

Practical implications
The research contributes to the international financial accounting literature about the banking industry. The results are relevant for researchers, accounting professionals, stakeholders, standard-setters and regulatory bodies that are concerned with Islamic banks’ disclosures.

Originality/value
Although AAOIFI was established since 1991, very few empirical studies about compliance with the FAS have been undertaken. To the authors’ knowledge, there are no studies that investigated the determinants of compliance level with AAOIFI FAS. Then, this study concentrates on disclosure accounting standards (FAS 1 and FAS 5) with a high risk of non-compliance.
Audit committees and financial reporting quality
Authors: Al-Shaer Habiba , Salama Aly , Toms Steven 
Published: January 2017

PurposeThe purpose of this paper is to examine the determinants of the volume of environmental disclosures and their quality, with particular focus on the role of audit committees (ACs) and the effects of the Smith report recommendations for the UK Corporate Governance Code.Design/methodology/approachQuantitative large sample analysis of UK FTSE350 companies for the period 2007-2011.FindingsFirms with higher quality ACs make higher quality disclosures. Larger firms with block shareholders have greater volume of disclosures, whilst AC quality does not increase disclosure volume.Research limitations/implicationsFindings are based on evidence from single country and imply further international comparative research.Practical implicationsACs mitigate the requirement for prescriptive legislation on narrative accounting disclosures relating to environmental issues.Originality/valueThe paper contributes to research that has examined the relationship between corporate governance mechanisms, specifically ACs, and the quality of financial reporting by considering voluntary narrative disclosures on environmental matters.