bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidental emotions influence risk preference and outcome evaluation
Authors: Zhao Ding , Gu Ruolei , Tang Ping , Yang Qiwei , Luo Yue‐Jia 
Published: June 2016

AbstractIncidental emotions, which are irrelevant to the current decision, play a significant role in the decision‐making process. In this study, to investigate the influence of incidental emotions on behavioral, psychological, and electrophysiological responses in the process of decision making, participants were required to perform a monetary gambling task. During the selection stage, an emotional picture, which was chosen from the Chinese Affective Picture System and fell into one of three categories: negative, neutral, and positive, was presented between two alternatives (small/large amount of bet). The pictures were provided to induce incidental emotions. ERPs and self‐rating emotional experiences to outcome feedback were recorded during the task. Behavioral results showed that positive incidental emotions elicited risk preference, but emotional experiences to outcome feedback were not influenced by incidental emotions. The feedback‐related negativity amplitudes were larger in the positive emotion condition than in the negative and neutral emotion conditions for small outcomes (including wins and losses), whereas there was no difference between the three conditions for large outcomes. In addition, the amplitudes of P3 were reduced overall in the negative emotion condition. We suggest that incidental emotions have modulated both the option assessment stage (manifested in behavioral choices) and the outcome evaluation stage (manifested in ERP amplitudes) of decision making unconsciously (indicated by unchanged subjective emotional experiences). The current findings have expanded our understanding of the role of incidental emotion in decision making.
Strategies to restore floodplain vegetation after abandonment of human activities
Authors: González Eduardo , Masip Adrià , Tabacchi Eric , Poulin Monique 
Published: June 2016

AbstractRestoring the flooding‐related disturbance regime by removing and setting back flood defenses (channel widening) is the most efficient strategy for recovering riparian plant communities in floodplains formerly impacted by human activities such as agriculture, mining, and forestry. Removing flood defenses is generally not socially accepted, and alternative recovery strategies must be explored. We assessed vegetation establishment on 33 sites in the floodplains of the Middle Ebro River and three of its tributaries (NE Spain) where restoration approaches applied in the last 20 years include channel widening, floodplain excavation, and abandonment of agriculture, gravel extraction, and hybrid poplar plantations, with and without plantation of native species. Using analysis of similarity and ordinations, we found that channel widening led to plant communities closely resembling those found on natural gravel bars, including new recruits of keystone tree species. Excavation of the floodplain as the restoration approach resulted in pioneer, non‐strictly riparian communities. Abandonment of agricultural land or clearing of poplar plantations resulted in alternative stable states predominating, regardless of time elapsed since restoration and whether poles of native species were planted. However, forest‐like communities relatively similar to mature, natural riparian references were attainable when hybrid poplars were allowed to resprout after clear‐cutting, or after the human activities were abandoned and trees were not cut. Combining channel widening and assisted revegetation where flood defenses cannot be altered may partially reproduce a mosaic of habitats typical of natural floodplains.
Metallogeny and Mineralization Potential of the Bazman Granitoids, SE Iran
Authors: Ghodsi Mohammad Reza , Boomeri Mohammad , Bagheri Sasan , Lentz David , Ishiyama Daizo 
Published: June 2016

AbstractThe Mesozoic Bazman granitoids are located in Sistan and Baluchestan province, southeastern Iran. Geology of the study area consists of Carboniferous shale, sandstone, and limestone and Permian siltstone, shale, sandstone, limestone, and dolomite that were intruded by the Bazman granitoids. These granitoids include various phases of granite, granodiorite, quartz‐monzodiorite, monzodiorite, diorite, and gabbro. They are metaluminous to slightly peraluminous, reduced, calc‐alkaline and I‐type, and display geochemical characteristics of continental margin (ensialic) granitoids. In this paper, field, petrography, and geochemical data were used to discriminate the Bazman granitoids either as productive or barren granitoids. Although there are a few skarn‐related mineral occurrences adjacent to the Bazman granitoids, most exposed intrusions are not hydrothermally altered and mineralized. Rb/Sr, Zr/Hf, and K/Rb ratios indicate that the granitic magmas that formed most of the Bazman granitoids indicate that they are moderately evolved and have generally not undergone post‐magmatic hydrothermal activity. The Sm/Eu and Rb/Ba ratios and the concentrations of Rb, Ba, and Sr within the aforementioned granitoids show that the rocks are similar to the averages of granitoids devoid of Li, Be, U, Sn, W, and Ta deposits. The I‐type arc characteristics and other geochemical features of the Bazman granitoids show that they are not typical of parental magmas to Sn, W, Mo, and Zn mineralization, but are mainly fertile for Cu and Fe (Au) skarn‐related granitoids.
Does Preschool Boost the Development of Minority Children?: The Case of Roma Children
Authors: Felfe Christina , Huber Martin 
Published: June 2016

Summary
Does universal preschool constitute an effective policy tool to promote the development and integration of children from minority groups? We address this question for the children of the Roma—the largest and most disadvantaged minority group in Europe. To tackle the issue of non-random selection into preschool, we exploit variation in the individual distance to the nearest preschool facility. Non-parametric instrumental variable estimations reveal significant short-term gains in terms of children's literacy. Preschool attendance also increases the prevalence of vaccinations but has no effect on other observed health outcomes. Overall, preschool also does not seem to enhance integration measured by children's language proficiency or social–emotional development, at least not in the short term.
Exploring myrmecophily based on the phylogenetic interrelationships of FalagoniaSharp, 1883 (Coleoptera: Staphylinidae: Aleocharinae) and allied genera
Authors: SANTIAGO‐JIMÉNEZ QUIYARI J. , ESPINOSA DE LOS MONTEROS ALEJANDRO 
Published: June 2016

AbstractThe taxonomy of Lomechusini Fleming has a complex history. Recent studies have shown that this group is polyphyletic; however, little is known about the evolutionary interrelationships among its constituent genera. The goals of the present study are to infer the phylogenetic relationships of Falagonia Sharp and closely related genera; to define the boundaries of those genera based on synapomorphic characters; and to explore the evolution of myrmecophily within the lineage. The phylogenetic analyses are based exclusively on morphological characters of adults. A total of 36 operational taxonomic units were used for the analysis. The best trees were selected based on maximum parsimony and Bayesian inference. During the parsimony reconstruction, different weighting strategies were used to recover the most robust phylogenetic hypothesis. Although minor differences were observed in the results of the different analyses, the topologies were consistent throughout. Several groups of genera proposed by Seevers (1965), such as the ‘Tetradonia’ and ‘Ecitopora’ groups, were not recovered. Thus, these may represent nonmonophyletic groups that were based on nonsynapomorphic diagnostic characters. Our analyses consistently recovered the genera Asheidium Santiago‐Jiménez, Delgadoidium Santiago‐Jiménez, Falagonia, Newtonidium Santiago‐Jiménez, Pseudofalagonia Santiago‐Jiménez, Sharpidium Santiago‐Jiménez, Tetradonia Wasmann and Thayeridium Santiago‐Jiménez, forming a monophyletic group that we have called the ‘Asheidium complex’. Falagonia mexicana Sharp shows seven autapomorphies, none of which were used to establish the genus. Based on the phylogenetic results, myrmecophily has evolved independently at least three times within the lineage. This study, based on morphological characters, is one of the first approaches towards gaining an understanding of the phylogenetic relationships within the polyphyletic tribe Lomechusini.
Spatial discovery and the research library
Authors: Lafia Sara , Jablonski Jon , Kuhn Werner , Cooley Savannah , Medrano F. Antonio 
Published: June 2016

AbstractAcademic libraries have always supported research across disciplines by integrating access to diverse contents and resources. They now have the opportunity to reinvent their role in facilitating interdisciplinary work by offering researchers new ways of sharing, curating, discovering, and linking research data. Spatial data and metadata support this process because location often integrates disciplinary perspectives, enabling researchers to make their own research data more discoverable, to discover data of other researchers, and to integrate data from multiple sources. The Center for Spatial Studies at the University of California, Santa Barbara (UCSB) and the UCSB Library are undertaking joint research to better enable the discovery of research data and publications. The research addresses the question of how to spatially enable data discovery in a setting that allows for mapping and analysis in a GIS while connecting the data to publications about them. It suggests a framework for an integrated data discovery mechanism and shows how publications may be linked to associated data sets exposed either directly or through metadata on Esri's Open Data platform. The results demonstrate a simple form of linking data to publications through spatially referenced metadata and persistent identifiers. This linking adds value to research products and increases their discoverability across disciplinary boundaries.
Distinct roles of the histone chaperones NAP1 and NRP and the chromatin‐remodeling factor INO80 in somatic homologous recombination in Arabidopsis thaliana
Authors: Zhou Wangbin , Gao Juan , Ma Jing , Cao Lin , Zhang Chi , Zhu Yan , Dong Aiwu , Shen Wen‐Hui 
Published: June 2016

SummaryHomologous recombination (HR) of nuclear DNA occurs within the context of a highly complex chromatin structure. Despite extensive studies of HR in diverse organisms, mechanisms regulating HR within the chromatin context remain poorly elucidated. Here we investigate the role and interplay of the histone chaperones NUCLEOSOME ASSEMBLY PROTEIN1 (NAP1) and NAP1‐RELATED PROTEIN (NRP) and the ATP‐dependent chromatin‐remodeling factor INOSITOL AUXOTROPHY80 (INO80) in regulating somatic HR in Arabidopsis thaliana. We show that simultaneous knockout of the four AtNAP1 genes and the two NRP genes in the sextuple mutant m123456‐1 barely affects normal plant growth and development. Interestingly, compared with the respective AtNAP1 (m123‐1 and m1234‐1) or NRP (m56‐1) loss‐of‐function mutants, the sextuple mutant m123456‐1 displays an enhanced plant hypersensitivity to UV or bleomycin treatments. Using HR reporter constructs, we show that AtNAP1 and NRP act in parallel to synergistically promote somatic HR. Distinctively, the AtINO80 loss‐of‐function mutation (atino80‐5) is epistatic to m56‐1 in plant phenotype and telomere length but hypostatic to m56‐1 in HR determinacy. Further analyses show that expression of HR machinery genes and phosphorylation of H2A.X (γ‐H2A.X) are not impaired in the mutants. Collectively, our study indicates that NRP and AtNAP1 synergistically promote HR upstream of AtINO80‐mediated chromatin remodeling after the formation of γ‐H2A.X foci during DNA damage repair.
Mucous membrane pemphigoid in dogs: a retrospective study of 16 new cases
Authors: Tham Heng L. , Olivry Thierry , Linder Keith E. , Bizikova Petra 
Published: June 2016

BackgroundMucous membrane pemphigoid (MMP) is a chronic autoimmune subepidermal blistering disease of dogs, cats and humans.ObjectivesThe goal of this study was to describe the clinical, histological and immunological features and treatment outcomes of canine MMP.AnimalsSixteen dogs were diagnosed with MMP based on the presence of mucosal‐ or mucocutaneous‐predominant vesiculation and/or ulceration, histological confirmation of subepidermal clefting and an age of disease onset greater than 6 months.ResultsSix of 16 dogs (38%) were German shepherd dogs and their crosses. The median age of disease onset was 6 years (range: 1–10 years). At the time of presentation, the dogs exhibited erosions and ulcers in the oral cavity (11 of 16; 69%), nasal (nine of 16; 56%), periocular (eight of 16; 50%) and genital (six of 16; 38%) regions. Haired skin lesions were less frequent (six of 16; 38%) and involved mostly concave pinnae. Information on treatment outcome was available for 11 dogs (69%). A complete remission (CR) of lesions was achieved in 10 of 11 dogs (91%). The median time to CR was 33 weeks (range: 6–64 weeks). Treatment regimens varied widely but six of 10 (60%) dogs received a combination of tetracycline antibiotic and niacinamide alone, or with another drug, at the time of CR. Forty percent of the dogs in which CR had occurred experienced lesion relapse upon drug dose reduction.Conclusions and clinical importanceCanine MMP is a chronic and relapsing disease requiring long term treatment. Combination therapy is often needed to achieve CR.
Assessing the risk of transfusion‐transmitted emerging infectious diseases
Authors: Custer B. 
Published: June 2016

BackgroundEmerging infectious diseases (EIDs) remain a source of significant concern in blood safety.MethodsEmerging infectious diseases of concern will be described and methods used to conduct risk assessment will be reviewed, with a focus on transfusion medicine. The issues that make EIDs more challenging for blood safety compared to other areas of public health will be demonstrated through specific examples.ResultsCurrent EIDs include mosquito‐borne infections such as dengue, chikungunya and Zika virus. In addition, tick‐borne infections such as Babesia, Borrelia, Anaplasma and Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) are or have the potential to become significant EIDs in transfusion. Other zoonoses, such as HEV, are expected to emerge or re‐emerge. Often in risk assessment, assumptions are made that transfusion‐transmitted (TT) infection will have the same progression as infection transmitted in other ways. Even with explosive mosquito‐borne epidemics of chikungunya virus, no evidence of TT has been documented. Substantial TT of dengue virus can occur, but significant clinical outcome differences between recipients of dengue RNA(+) and RNA(−) transfusions have not been found. In contrast, while TT of Babesia microti in the USA is a clear threat, there is no consensus on appropriate risk mitigation.SummaryGeneralizations from one route of transmission to another and from one pathogen to another may be appropriate for precaution, but may lead to ineffective and cost‐ineffective policies. For risk assessment and blood safety policy to be evidence based, studies of the consequences to blood recipients need to be conducted.
Current status and new developments in the production of plasma derivatives
Authors: Burnouf T. 
Published: June 2016

Plasma fractionation is a unique biotechnology and bioengineering industry characterized by its capacity to extract a diverse range of protein therapeutics that are often the only options for treating life‐threatening pathological conditions of patients suffering from bleeding, immunological disorders, infections or trauma. Current plasma products include several coagulation factors, polyvalent and hyperimmune immunoglobulins (Igs), albumin, protease inhibitors and anticoagulants. In many pathological situations, these products are used for long‐term replacement therapy to compensate for a congenital or acquired protein deficiency. Most products are obtained by plasma fractionation technologies that derive from the cold ethanol fractionation process developed in the mid‐/late 1940s by Cohn and collaborators. Still, in the last 20 years, this core technology has undergone substantial evolutions illustrated by the integration of several viral reduction steps for all products and by the introduction of chromatographic purification steps to extract labile proteins from cryoprecipitate‐poor plasma. The most recent technological changes, intended mostly to improve recoveries and remove trace protein contaminants, concern the production process of intravenous Igs through implementing chromatographic steps and caprylic acid treatment in early stages of the ethanol fractionation process. A number of new fractionation technologies are currently under development and have not been licensed at least for the time being by major regulatory authorities. One target of these technologies is to improve the recovery of the most important plasma protein products, under conditions facilitating large‐scale implementation in emerging countries.
Modular modelling with Physiome standards
Authors: Cooling Michael T. , Nickerson David P. , Nielsen Poul M. F. , Hunter Peter J. 
Published: June 2016

Key points
The complexity of computational models is increasing, supported by research in modelling tools and frameworks. But relatively little thought has gone into design principles for complex models.
We propose a set of design principles for complex model construction with the Physiome standard modelling protocol CellML.
By following the principles, models are generated that are extensible and are themselves suitable for reuse in larger models of increasing complexity.
We illustrate these principles with examples including an architectural prototype linking, for the first time, electrophysiology, thermodynamically compliant metabolism, signal transduction, gene regulation and synthetic biology.
The design principles complement other Physiome research projects, facilitating the application of virtual experiment protocols and model analysis techniques to assist the modelling community in creating libraries of composable, characterised and simulatable quantitative descriptions of physiology.
AbstractThe ability to produce and customise complex computational models has great potential to have a positive impact on human health. As the field develops towards whole‐cell models and linking such models in multi‐scale frameworks to encompass tissue, organ, or organism levels, reuse of previous modelling efforts will become increasingly necessary. Any modelling group wishing to reuse existing computational models as modules for their own work faces many challenges in the context of construction, storage, retrieval, documentation and analysis of such modules. Physiome standards, frameworks and tools seek to address several of these challenges, especially for models expressed in the modular protocol CellML. Aside from providing a general ability to produce modules, there has been relatively little research work on architectural principles of CellML models that will enable reuse at larger scales. To complement and support the existing tools and frameworks, we develop a set of principles to address this consideration. The principles are illustrated with examples that couple electrophysiology, signalling, metabolism, gene regulation and synthetic biology, together forming an architectural prototype for whole‐cell modelling (including human intervention) in CellML. Such models illustrate how testable units of quantitative biophysical simulation can be constructed. Finally, future relationships between modular models so constructed and Physiome frameworks and tools are discussed, with particular reference to how such frameworks and tools can in turn be extended to complement and gain more benefit from the results of applying the principles.
Competitive Swimming and Handball Participation Have a Positive Influence on Bone Parameters as Assessed by Phalangeal Quantitative Ultrasound in Female Adolescents
Authors: Krahenbuhl Tathyane , Gonçalves Ezequiel Moreira , Guimarães Roseane de Fatima , Guerra-Júnior Gil , Barros-Filho Antonio de Azevedo 
Published: June 2016

Purpose:To examine the influence of participation in competitive sports on bone parameters, as assessed by quantitative ultrasound (QUS) of the phalanges in female adolescents.Methods:Female adolescents (n = 329, 13.0–16.7 years old) were classified into handball (n = 55), swimming (n = 49) and control (n = 225) groups. QUS was used to evaluate the amplitude-dependent speed of sound (AD-SoS) and bone transmission time (BTT), and their z-scores (zAD-SoS and zBTT) were calculated. Anthropometric measurements and Tanner’s stages were also obtained.Results:Swimmers had higher AD-SoS (2089 ± 43.8 m/s) and zAD-SoS (0.47 ± 0.8) than controls (2060 ± 54.0 m/s; 0.09 ± 1.0; both p ≤ .05) and both groups of athletes had higher BTT (handball: 1.44 ± 0.2 μs; swimming: 1.45 ± 0.2) and zBTT (handball: 0.71 ± 0.8; swimming: 0.72 ± 1.1) than the control group (1.37 ± 0.2 μs; 0.32 ± 0.9; all p ≤ .05). Swimmers had a higher total training time (TTT: 52.5 ± 27.6 months) and frequency of training per week (FT: 5.38 ± 0.1) compared with the handball group (35.9 ± 18.1; 3.32 ±0.8; p ≤ .05). zAD-SoS, BTT and zBTT were positively correlated with FT, while BTT and zBTT showed a positive correlation with TTT.Conclusions:Sports practice influences bone parameters and higher bone parameter values are related to the amount of time and frequency of weekly training. The differences in phalangeal QUS parameters are independent of the impact of weight-bearing exercise.
Antibacterial Efficacy of Eravacycline
In Vivo
against Gram-Positive and Gram-Negative Organisms
Authors: Monogue Marguerite L. , Thabit Abrar K. , Hamada Yukihiro , Nicolau David P. 
Published: June 2016

ABSTRACT

Members of the tetracycline class are frequently classified as bacteriostatic. However, recent findings have demonstrated an improved antibacterial killing profile, often achieving ≥3 log
10
bacterial count reduction, when such antibiotics have been given for periods longer than 24 h. We aimed to study this effect with eravacycline, a novel fluorocycline, given in an immunocompetent murine thigh infection model over 72 h against two methicillin-resistant
Staphylococcus aureus
(MRSA) isolates (eravacycline MICs = 0.03 and 0.25 μg/ml) and three
Enterobacteriaceae
isolates (eravacycline MICs = 0.125 to 0.25 μg/ml). A humanized eravacycline regimen, 2.5 mg/kg of body weight given intravenously (i.v.) every 12 h (q12h), demonstrated progressively enhanced activity over the 72-h study period. A cumulative dose response in which bacterial density was reduced by more than 3 log
10
CFU at 72 h was noted over the study period in the two Gram-positive isolates, and eravacycline performed similarly to comparator antibiotics (tigecycline, linezolid, and vancomycin). A cumulative dose response with eravacycline and comparators (tigecycline and meropenem) over the study period was also observed in the Gram-negative isolates, although more variability in bacterial killing was observed for all antibacterial agents. Overall, a bacterial count reduction of ≥3 log was achieved in one of the three isolates with both eravacycline and tigecycline, while meropenem achieved a similar endpoint against two of the three isolates. Bactericidal activity is typically defined
in vitro
over 24 h; however, extended regimen studies
in vivo
may demonstrate an improved correlation with clinical outcomes by better identification of antimicrobial effects.