bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of an alternative approach to measuring quality in a volume-to-value world: a case study of diabetes care
Authors: Coombs Letoynia Jenee , Burston Betty , Liu Darren 
Published: December 2017

BackgroundTo develop a statistical tool that allows practitioners and/or their practice managers to easily select the relevant range in which volume and value are maximised.MethodsData for the study were based on 55 primary care practices that participated in the Colorado Improving Performance in Practice programme in 2014. We used two composite variables including the volume of processes of care variables listed in Diabetes Practice Guidelines and value (quality) as measured by changes in the intermediate outcomes. We assessed volume/value trade-offs using a multilevel model with a time-varying covariate partitioned into a between-practice and within-practice effect.ResultsThe study revealed a strong linear relationship between volume and value (P<0.0001). Specifically, practices with an above-average volume of care as measured by their process of care scores also had above-average quality outcomes (expected value 57; average volume 49.48) as quantified by their intermediate outcome scores. Additionally, in those months when practices provided a volume of care that exceeded their average process of care score, further improvements occurred in quality as measured by intermediate outcome scores (P<0.0001).ConclusionSuch findings suggest an inherent linkage between volume of care and quality. This statistical approach, if provided as an app containing an easy-to-use statistical calculator, will allow practice managers and clinicians to systematically identify volume/quality trade-offs, thereby reducing undertreatment and/or overtreatment among patients with chronicities.
Surgical correction of four cases of hydrometra in ewes
Authors: Brabant Olivia , Laurence Michael 
Published: December 2017

Four nulliparous, pet, merino ewes from the same property were evaluated at The Animal Hospital at Murdoch University, Western Australia, over a one‐year period. The ewes presented with a history of chronic serosanguinous vaginal discharge. Age ranged from 5 to 11 years. Medical treatment with cloprostenol (Juramate, Jurox) and oxytocin (Syntocin, Ilium) failed in two ewes. A decision to surgically manage the cases was made. Midline laparotomy and surgical ovariohysterectomy resulted in permanent resolution of clinical signs. The first uterus and ovaries were submitted for histopathological examination and hydrometra was confirmed. Hydrometra is a known cause of infertility in sheep however more frequently noted as an incidental finding on abattoir specimens. It is an uncommon histopathological diagnosis. This case report expands the differentials for vaginal discharge in ewes, provides details of surgical correction of hydrometra and highlights the increased likelihood of unusual clinical presentations in older livestock kept as pets.
Integrated Molecular Characterization of the Lethal Pediatric Cancer Pancreatoblastoma
Authors: Isobe Tomoya , Seki Masafumi , Yoshida Kenichi , Sekiguchi Masahiro , Shiozawa Yusuke , Shiraishi Yuichi , Kimura Shunsuke , Yoshida Misa , Inoue Yoshikage , Yokoyama Akira , Kakiuchi Nobuyuki , Suzuki Hiromichi , Kataoka Keisuke , Sato Yusuke , Kawai Tomoko , Chiba Kenichi , Tanaka Hiroko , Shimamura Teppei , Kato Motohiro , Iguchi Akihiro , Hama Asahito , Taguchi Tomoaki , Akiyama Masaharu , Fujimura Junya , Inoue Akiko , Ito Tsuyoshi , Deguchi Takao , Kiyotani Chikako , Iehara Tomoko , Hosoi Hajime , Oka Akira , Sanada Masashi , Tanaka Yukichi , Hata Kenichiro , Miyano Satoru , Ogawa Seishi , Takita Junko 
Published: December 2017

Abstract
Pancreatoblastoma is a rare pediatric pancreatic malignancy for which the molecular pathogenesis is not understood. In this study, we report the findings of an integrated multiomics study of whole-exome and RNA sequencing as well as genome-wide copy number and methylation analyses of ten pancreatoblastoma cases. The pancreatoblastoma genome was characterized by a high frequency of aberrant activation of the Wnt signaling pathway, either via somatic mutations of CTNNB1 (90%) and copy-neutral loss of heterozygosity (CN-LOH) of APC (10%). In addition, imprinting dysregulation of IGF2 as a consequence of CN-LOH (80%), gain of paternal allele (10%), and gain of methylation (10%) was universally detected. At the transcriptome level, pancreatoblastoma exhibited an expression profile characteristic of early pancreas progenitor-like cells along with upregulation of the R-spondin/LGR5/RNF43 module. Our results offer a comprehensive description of the molecular basis for pancreatoblastoma and highlight rational therapeutic targets for its treatment.
Significance: Molecular genetic analysis of a rare untreatable pediatric tumor reveals Wnt/IGF2 aberrations and features of early pancreas progenitor-like cells, suggesting cellular origins and rational strategies for therapeutic targeting. Cancer Res; 78(4); 865–76. ©2017 AACR.
Dilemas e perspectivas da abordagem sociológica dos desastres naturais
Authors: Mattedi Marcos 
Published: December 2017

O texto examina as controvérsias da abordagem sociológica dos desastres valendo-se dos subsídios extraídos da sociologia da ciência. Mais precisamente, considera os impasses cognitivos e políticos inerentes à sociologia dos desastres por meio das contribuições produzidas pelo estudo das controvérsias científicas. Sustenta que o desenvolvimento da abordagem sociológica dos desastres estrutura-se em torno de três controvérsias: (a) interdisciplinar: oposição evento-impacto; (b) intradisciplinar: oposição consenso-conflito; (c) extradisciplinar: oposição leigo-perito. Para tentar ultrapassar esses obstáculos, o texto apresenta o modelo Problema-Solução extraído do desenvolvimento da sociologia da ciência e da tecnologia. Com base nesse modelo teórico visa apresentar uma nova definição de desastres. Para desenvolver esse argumento, o texto foi dividido em cinco partes principais: (1) inicia com uma apresentação da problemática sociotécnica do estudo dos desastres; (2) segue com a apresentação das controvérsias interdisciplinares; (3) em seguida, das controvérsias intradisciplinares; (4) e das controvérsias extradisciplinares; (5) e termina com a formulação de uma nova definição de desastre
Land–Atmosphere Interactions: The LoCo Perspective
Authors: Santanello Joseph A. , Dirmeyer Paul A. , Ferguson Craig R. , Findell Kirsten L. , Tawfik Ahmed B. , Berg Alexis , Ek Michael , Gentine Pierre , Guillod Benoit P. , van Heerwaarden Chiel , Roundy Joshua , Wulfmeyer Volker 
Published: December 2017

AbstractLand–atmosphere (L-A) interactions are a main driver of Earth’s surface water and energy budgets; as such, they modulate near-surface climate, including clouds and precipitation, and can influence the persistence of extremes such as drought. Despite their importance, the representation of L-A interactions in weather and climate models remains poorly constrained, as they involve a complex set of processes that are difficult to observe in nature. In addition, a complete understanding of L-A processes requires interdisciplinary expertise and approaches that transcend traditional research paradigms and communities. To address these issues, the international Global Energy and Water Exchanges project (GEWEX) Global Land–Atmosphere System Study (GLASS) panel has supported “L-A coupling” as one of its core themes for well over a decade. Under this initiative, several successful land surface and global climate modeling projects have identified hot spots of L-A coupling and helped quantify the role of land surface states in weather and climate predictability. GLASS formed the Local Land–Atmosphere Coupling (LoCo) project and working group to examine L-A interactions at the process level, focusing on understanding and quantifying these processes in nature and evaluating them in models. LoCo has produced an array of L-A coupling metrics for different applications and scales and has motivated a growing number of young scientists from around the world. This article provides an overview of the LoCo effort, including metric and model applications, along with scientific and programmatic developments and challenges.
Weather-Induced Transport through a Tidal Channel Calibrated by an Unmanned Boat
Authors: Li Chunyan , Weeks Eddie , Huang Wei , Milan Brian , Wu Renhao 
Published: December 2017

AbstractAn unmanned surface vehicle (USV) was designed and constructed to operate continuously for covering both flood and ebb and preferably a complete tidal cycle (e.g., ~24 h) to measure the vertical profiles of horizontal flow velocity. It was applied in a tidal channel at Port Fourchon, Louisiana. A bottom-mounted ADCP was deployed for 515 days. The first EOF mode of the velocity profiles showed a barotropic type of flow that explained more than 98.2% of the variability. The second mode showed a typical estuarine flow with two layers, which explained 0.47% of the variability. Using a linear regression of the total transport from the USV with the vertically averaged velocity from the bottom-mounted ADCP, with an R-squared value of 98%, the total along-channel transport throughout the deployment was calculated. A low-pass filtering of the transport allowed for examining the impact of 76 events with cold, warm, or combined cold–warm fronts passing the area. The top seven most severe events were discussed, as their associated transports obviously stood out in the time series, indicating the importance of weather. It is shown that large-scale weather systems with frontal lines of ~1500–3000-km horizontal length scale control the subtidal transport in the area. Cold (warm) fronts tend to generate outward (inward) transports, followed by a rebound. The maximum coherence between the atmospheric forcing and the ocean response reached ~71%–84%, which occurred at about a frequency f of ~0.29 cycle per day or T of ~3.4 days in the period, consistent with the atmospheric frontal return periods (~3–7 days).
New fired bricks based on municipal solid waste incinerator bottom ash
Authors: Taurino R , Karamanova E , Barbieri L , Atanasova-Vladimirova S , Andreola F , Karamanov A 
Published: December 2017

The main objective of this work was to study the sintering process and technological properties of new fired bricks based on high amount of post-treated municipal solid waste incinerator bottom ash and refractory clay. In addition, the effect of the minor addition of flux (Na2CO3) or reinforce (corundum) was also highlighted. Several methods were used to study the effect of compositions variations on the sintering process, structure and the mechanical characteristics of the test briquettes. Differential thermal analysis (TG/DTA) and dilatometry techniques were applied to study the thermal behaviour while scanning electron microscopy coupled with energy-dispersive X-ray spectroscopy and high-temperature X-ray diffraction were used to elucidate the structure and the phase composition. The mechanical characteristics were estimated by micro-indentation, strength and various physical tests (porosity, linear shrinkage and water absorption, etc). The results highlight the possibility to use very high amount of municipal solid waste incinerator bottom ashes in the production of new fired bricks with good performances at all levels. It is also shown that the addition of additives managed the final properties, affecting the crystal phase formation, porosity and greatly the strength of the samples.
Randomized, Placebo-controlled Crossover Study of Dalfampridine Extended-release in Transverse Myelitis
Authors: Schwartz Kateryna , Wymbs Nicholas F , Huang Hwa , Mealy Maureen A , Pardo Carlos A , Zackowski Kathleen , Levy Michael 
Published: December 2017

Background Dalfampridine has the potential to be effective in patients with transverse myelitis (TM) as this rare disorder shares some clinical and pathogenic similarities with multiple sclerosis. Methods This is a randomized, double-blind, placebo-controlled crossover study of dalfampridine extended-release (D-ER, Ampyra®). Sixteen adult study participants with monophasic TM confirmed by MRI were enrolled if their baseline timed 25-foot walking speed was between 5 and 60 seconds. Participants were randomized to receive 10 mg twice-daily doses of either D-ER or placebo control for eight weeks, then crossed over to the second arm of placebo or dalfampridine for eight weeks. The primary outcome measure was the timed 25-foot walk. Results Of 16 enrolled participants, three withdrew and 13 completed the trial. Among the 13 completers, nine individuals showed an average timed walk that was faster in the D-ER arm compared to the placebo arm, but only four participants met the stricter statistical threshold to be classified as a responder. Analyses of secondary clinical outcome measures including strength, balance assessments, spasticity, and Expanded Disability Status Scale (EDSS) score showed trends toward improvement with D-ER. Conclusions D-ER may be beneficial in TM to improve walking speed and other neurological functions.
Dehydration-hydration reactivity of laumontite: analyses and tests for easy detection
Authors: Bravo Arturo , Jerez Oscar , Kelm Ursula , Poblete Mauro 
Published: December 2017

AbstractHydration reactions are known to affect rock or aggregate stability in construction; laumontite is not usually considered to be a ‘problem-mineral’ though drill cores from the very low-grade metamorphic altered andesites and volcanoclastic rocks from Central Chile showed detachments of shotcrete in a tunnel exposed to periodic water flow, with expandable clay phases presumed to be responsible for the observed failure. Abundant laumontite detected in the cores may also be responsible for the detachment, however, resulting from the structural expansion and contraction in response to hydration and drying. Clay reactivity in construction projects is often tested on site by 30 days of ethylene glycol exposure, but adequate monitoring options for laumontite are not deployed. Options for laumontite characterization involving a combination of water immersion and slaking and modified oedometer-based expansibility tests were used here to observe the response to laumontite expansion pressure. All tests were formulated considering minimal implementation efforts for building sites or the easy availability of analytical and testing facilities.Laumontite was identified by optical microscopy, semiquantitative X-ray diffraction, and automated mineralogical analysis. A combination of the latter two methods provided reliable information about the presence of sub-microscopic laumontite and a visual impression of the textural arrangement of the zeolite in the rock.A slaking test based on four cycles of immersion followed by drying and final application of weight (simulated overburden) is best suited to indirect detection and for demonstrating rock reactivity due to the presence of laumontite. Rocks with laumontite show expansion when crushed, recompacted and fitted into an oedometer, but mineralogical information is required for adequate interpretation of the results.
Retract p < 0.005 and propose using JASP, instead
Authors: Perezgonzalez Jose D. , Frías-Navarro M. Dolores 
Published: December 2017

Seeking to address the lack of research reproducibility in science, including psychology and the life sciences, a pragmatic solution has been raised recently: to use a stricter p < 0.005 standard for statistical significance when claiming evidence of new discoveries. Notwithstanding its potential impact, the proposal has motivated a large mass of authors to dispute it from different philosophical and methodological angles. This article reflects on the original argument and the consequent counterarguments, and concludes with a simpler and better-suited alternative that the authors of the proposal knew about and, perhaps, should have made from their Jeffresian perspective: to use a Bayes factors analysis in parallel (e.g., via JASP) in order to learn more about frequentist error statistics and about Bayesian prior and posterior beliefs without having to mix inconsistent research philosophies.
Gender politics of the ‘war of narratives’: Russian TV-news in the times of conflict in Ukraine
Authors: Voronova Liudmila 
Published: December 2017

Abstract
This article focuses on the gender politics of the news broadcast on the Russian state-controlled TV channels – Channel One (Pervyj kanal), Russia-1 (Rossiya-1), Russia-24 (Rossiya-24), NTV and RT (formerly Russia Today) – from January to September 2015, a period when the TV news closely followed the conflict in Ukraine and the growing tensions between Russia and Europe. The study shows that the news on the state-controlled TV channels interpret the state politics in only one possible way – ascribing the most traditional and essentialist characteristics to the country, prioritizing male actors and military activities and suggesting no alternatives to ‘(re)masculinization’ of the image of Russia in the situation of the conflict on the territory of another state, despite the alleged disengagement of the country in it. The article concludes that the state-controlled TV channels use essentialist gendering as a part of nation-branding and nation-building strategies, with an aim to construct the gendered and intersectionalized ideology of the ‘Russian world’ that would target both internal and external audiences and go beyond the borders of the Russian Federation.
Bodily Capital and the Strength and Conditioning Professional
Authors: Edmonds Shaun 
Published: December 2017

ABSTRACT
BOURDIEU'S THEORY OF DIFFERENCE IS A USEFUL SOCIOLOGICAL THEORY FOR EXPLORING THE WAYS IN WHICH A STRENGTH AND CONDITIONING PROFESSIONAL'S PHYSICAL APPEARANCE MAY FACTOR IN TO ASSUMPTIONS ABOUT THEIR KNOWLEDGE AND SKILLS. THROUGH BOURDIEU'S CONCEPT OF BODILY CAPITAL, THIS ARTICLE EXAMINES THE WAYS IN WHICH THE PHYSICAL APPEARANCE OF THE BODY IS OFTEN INTERPRETED AS A MARKER OF KNOWLEDGE AND EXPERTISE. THE CONFLATION OF PHYSICAL APPEARANCE WITH COACHING AND TRAINING ABILITY HAS NUMEROUS ECONOMIC, SOCIAL, AND CULTURAL IMPLICATIONS WITHIN THE STRENGTH AND CONDITIONING FIELD.
Nationwide multicenter study on the management of pulmonary neuroendocrine (carcinoid) tumors
Authors: Sadowski Samira M , Christ Emanuel , Bédat Benoit , Kollár Attila , Karenovics Wolfram , Perren Aurel , Triponez Frédéric , _ _ 
Published: December 2017

Background and aim
To analyze the management and outcome of patients with primary typical (TC) and atypical lung carcinoids (AC) in Switzerland.

Methods
Retrospective analysis of patients selected from a neuroendocrine tumor (NET) registry. Patients were divided into TC and AC according to pathology reports, and surgical procedures were grouped as wedge/segmentectomy, lobectomy/bilobectomy and pneumectomy. Survival analysis was performed using the Kaplan–Meier method and log-rank test.

Results
Over 7 years, 113 pulmonary carcinoids (61.9% females, mean age 59.4 years) were included from 19 hospitals, with pathology data on Ki67 and necrosis incomplete in 16 cases. Eighty-three TC and 14 AC underwent surgical resection with a primary tumor size of median 14.5 (range 1–80) mm and diagnosis was established in 55.8% at surgery. Mean follow-up was 30.2 ± 23.1 months. Lobectomy was performed in 54.2% and wedge resection in 17.7% of cases. Six patients received additional systemic therapy. There was a trend for larger primary lesion size and a significantly higher rate of N2–N3 status in AC. Mean survival tended to be increased in patients with TC compared to AC (86.1 vs 48.4 months, P = 0.06) and mean disease-free interval after surgical resection was 74.1 and 48.3 months for TC and AC, respectively (P = 0.74).

Conclusion
AC of the lung has a more malignant behavior and a trend to a worse outcome. The results of this registry reinforce the need for standardized histological diagnosis and inter-disciplinary therapeutic decision making to improve the quality of care of patients with TC and AC.
Characterizing the Natural Temperature and Humidity Environment Severity
Authors: Aldridge Dustin S. 
Published: December 2017

Abstract
Severe yet common product environmental tests are 1000 hours at 85 °C/85% RH or 95 °C/95% RH for products, circuit card assemblies, and electronic components. Such environments never occur naturally; however, they attempt to simulate the corrosion damage that could be expected in service. To what natural environment do these tests correlate? Further, how do tests based on MIL-HDBK-310, MIL-STD-810, and STANAG 2895 B3 daily environments compare to these standard test environments? The analysis employs the Physics-of-Failure (POF) Peck power law temperature-humidity model with common conservative values for the Arrhenius activation energy and the relative humidity exponent, based on aluminum corrosion, coupled with climatological data from 49 United States weather stations and 19 international locations. The monthly average temperature and humidity extremes were transformed into an hourly diurnal cycle assumed to occur every day of each month. Using the power law model the equivalent time at the test condition was calculated for each day, and summed for each month and location. The 85 °C/85% RH test can be correlated with about 10 years in a hot and moist natural environment, such as Singapore, with 1000 hours of 95 °C/95% RH exposure equivalent to 25 years. Long-term tests based on the worst-case diurnal temperature and humidity cycles in military standards are on the order of 1 in 1,000,000 probability of occurrence in nature.
Mujeres y pobreza: una discusión entre universalismo y el paternalismo
Authors: Rivera Sanín María Lucía 
Published: December 2017

<p class="p1"><span class="Apple-converted-space"> </span>La discusión sobre la justicia en relación con la calidad de vida constituye un aporte significativo de la teoría de las capacidades propuesta por Amartya Sen y Martha Nussbaum. Dicha teoría propone la existencia de necesidades y umbrales mínimos de bienestar para todos los seres humanos, y defiende un universalismo de las consideraciones sobre lo justo y lo injusto. Este universalismo, sin embargo, despierta preguntas sobre la posibilidad de un paternalismo que contradiga los cimientos liberales de la propuesta. A partir de un análisis de las relaciones y tensiones entre el liberalismo político y la teoría de las capacidades, este escrito expondrá algunas reflexiones basadas en el tratamiento que Martha Nussbaum hace de la circunstancia de las mujeres pobres en la India.</p>
Intra-Articular Patellar Dislocation: A Technique for Closed Reduction
Authors: Wight Lachlan , James Dugal 
Published: December 2017

Case:
An 87-year-old man fell onto a flexed knee and sustained a closed intra-articular patellar dislocation. A closed reduction was performed under intravenous sedation by flexing the knee to 90°, applying an anterior drawer force to the tibia, and applying pressure to the inferior pole of the patella. The day after reduction, weight-bearing was begun in a hinged brace set at 0° to 90°. Full function was regained by 6 weeks postreduction.

Conclusion:
Intra-articular patellar dislocation may present as an unusual cause of a locked knee. Our experience confirms that it can be managed successfully with closed reduction under light sedation in an emergency department.