bluuebunny/crossref_metadata_2025_split huggingface dataset:
The National Earth System Prediction Capability: Coordinating the Giant
Authors: Carman Jessie C. , Eleuterio Daniel P. , Gallaudet Timothy C. , Geernaert Gerald L. , Harr Patrick A. , Kaye Jack A. , McCarren David H. , McLean Craig N. , Sandgathe Scott A. , Toepfer Frederick , Uccellini Louis W. 
Published: August 2016

Abstract
The United States has had three operational numerical weather prediction centers since the Joint Numerical Weather Prediction Unit was closed in 1958. This led to separate paths for U.S. numerical weather prediction, research, technology, and operations, resulting in multiple community calls for better coordination. Since 2006, the three operational organizations—the U.S. Air Force, the U.S. Navy, and the National Weather Service—and, more recently, the Department of Energy, the National Aeronautics and Space Administration, the National Science Foundation, and the National Oceanic and Atmospheric Administration/Office of Oceanic and Atmospheric Research, have been working to increase coordination. This increasingly successful effort has resulted in the establishment of a National Earth System Prediction Capability (National ESPC) office with responsibility to further interagency coordination and collaboration. It has also resulted in sharing of data through an operational global ensemble, common software standards, and model components among the agencies. This article discusses the drivers, the progress, and the future of interagency collaboration.
Paternalismv. autonomy – are we barking up the wrong tree?
Authors: Lepping Peter , Palmstierna Tom , Raveesh Bevinahalli N. 
Published: August 2016

SummaryWe explore whether we can reduce paternalism by increasing patient autonomy. We argue that autonomy should not have any automatic priority over other ethical values. Thus, balancing autonomyv.other ethical pillars and finding the optimal balance between the patient's wishes and those of other relevant stakeholders such as the patient's family has to be dynamic over time.
Patients or prisoners? Time to reconsider the voting rights of mentally disordered offenders
Authors: Rees Gareth , Reed James 
Published: August 2016

SummaryAlthough the Representation of the People Act 2000 permits most psychiatric in-patients to register on the electoral register, transferred prisoners and those admitted to hospital under hospital orders remain disenfranchised by law. This article clarifies the voting rights of individuals receiving in-patient psychiatric care and contends that the selective disenfranchisement of some mentally disordered offenders is problematic, discriminatory and may breach international human rights law. There are therefore strong arguments for the UK government to address this long-standing inequality before the next general election.
A multidimensional Framework for Routine Outcome Measurement in Liaison Psychiatry (FROM-LP)
Authors: Trigwell Peter , Kustow James 
Published: August 2016

SummaryIn the field of liaison psychiatry, as in all areas of healthcare, there is an essential need for well-organised and consistent collection of information on outcomes, from a range of perspectives. This special article introduces, and describes the development of, the multidimensional Framework for Routine Outcome Measurement in Liaison Psychiatry (FROM-LP). This was challenging owing to the variety of service settings and types of intervention which characterise liaison psychiatry. Similar challenges may be faced by other specialties and this, along with the direct relevance of much of the eventual content of the framework, will broaden the interest of this article.
It is time to bring borderline intellectual functioning back into the main fold of classification systems
Authors: Wieland Jannelien , Zitman Frans G. 
Published: August 2016

SummaryBorderline intellectual functioning is an important and frequently unrecognised comorbid condition relevant to the diagnosis and treatment of any and all psychiatric disorders. In the DSM-IV-TR, it is defined by IQ in the 71–84 range. In DSM–5, IQ boundaries are no longer part of the classification, leaving the concept without a clear definition. This modification is one of the least highlighted changes in DSM–5. In this article we describe the history of the classification of borderline intellectual functioning. We provide information about it and on the importance of placing it in the right context and in the right place in future DSM editions and other classification systems such as the International Classification of Diseases.
Service and treatment engagement of people with very late-onset schizophrenia-like psychosis
Authors: Lam Chun Chiang Sin Fai , Reeves Suzanne J. , Stewart Robert , Howard Robert 
Published: August 2016

Aims and methodElectronic patient records were used to investigate the level of engagement and treatment that patients with very late-onset schizophrenia-like psychosis (VLOSLP) had with mental health services.ResultsOf 131 patients assessed and diagnosed, 63 (48%) were taking antipsychotic treatment at 3 months, 46 (35%) at 6 months and 36 (27%) at 12 months. At discharge from mental health services, 54% of patients had failed to engage with services or became lost to follow-up, 18% had engaged with services but were not taking antipsychotic medication and only 28% were taking treatment.Clinical implicationsResults showed that less than half of the patients with VLOSLP were commenced on antipsychotic treatment and less than a third remained on treatment at 1 year or at point of discharge. This highlights the need for services to consider being more assertive in taking potentially effective treatment to this patient group.
The use of collagen matrix (Ologen) as a patch graft in glaucoma tube shunt surgery, a retrospective chart review
Authors: Stephens John D. , Sarkisian, Jr. Steven R. 
Published: August 2016

Purpose: To determine the safety and efficacy of collagen matrix as a patch graft in glaucoma drainage surgery. Collagen matrix grafts may be advantageous because they do not need to be harvested from human donors. Methods: An institutional, retrospective review of 43 patients with at least 12 months follow-up status post-glaucoma drainage implant surgery were evaluated for signs of tube erosion after initial placement of collagen matrix patch graft. Results: Forty-one of 43 eyes (95.3%) required no intervention for patch graft melting with tube erosion. Average time of follow-up was 32 months (range: 12-45). Two cases had tube erosion at 4 months and 26 months post-op requiring tube revision, which was successfully revised with conjunctiva (4 month erosion) and donor sclera (26 month erosion). Conclusion: Our results suggest that collagen matrix patch grafts may be used successfully as a patch graft in glaucoma tube shunt surgery, and may be advantageous because they do not have to be harvested from human donors. It is possible that exposure rates may be higher after longer follow-up and with larger numbers of patients. Further research is needed to compare Ologen to traditional graft materials to conclusively determine the safety and efficacy of collagen matrix as a novel patch graft material.
Teaching and learning preferences of ‘Generation Y’ occupational therapy students in practice education
Authors: Hills Caroline , Levett-Jones Tracy , Warren-Forward Helen , Lapkin Samuel 
Published: August 2016

Background/Aims: Practice education is integral to health professional curricula. There is emerging evidence that student generational attributes may be impacting on practice education. Students born between 1982 and 2000, termed ‘Generation Y’, are said to have a different outlook on learning to those students from other generational groups. However, there is little research from student perspectives to investigate these claims. This study aimed to identify ‘Generation Y’ occupational therapy students' preferred teaching and learning approaches in practice education. Methods: Using a qualitative descriptive approach and purposive sampling, 22 semi-structured interviews were undertaken with third and fourth year ‘Generation Y’ occupational therapy students from one Australian university. Interview transcripts were analysed thematically. Findings: Four themes emerged from the data: developing practice skills and confidence; essential communication; valued educational approaches; and the supervisory relationship and the team. Conclusion: Findings relate to ‘Generation Y’ characteristics. Practice educators may need to consider that these students have unique learning preferences. Students prefer ‘doing’ to observing, they want to be given clear expectations and responsibility for their own work tasks, they want to work in a team, they prefer to self-evaluate prior to feedback and access to the internet is essential for their learning.
Cross-cultural adaptation, validity and reliability of the Hausa version of the Neck Disability Index questionnaire
Authors: Kaka Bashir , O Ogwumike Omoyemi , Vernon Howard , F Adeniyi Ade , O Ogunlade Samuel 
Published: August 2016

Background/Aims: The aim of this study was to translate and cross-culturally adapt initiated psychometric tests of the Neck Disability Index (NDI) questionnaire into Hausa language. The prevalence of neck conditions among Hausa patients in Northern Nigeria necessitates the use of the NDI questionnaire. The fact that there was no Hausa version of this instrument has limited its use, hence there is a need for its translation into the Hausa language. Methods: The English version of the NDI questionnaire was translated into Hausa language through a forward and backward translation process. Sixty-two patients were selected for validation of the questionnaire using a purposive sampling technique. The original English version (NDI) and the Hausa version (NDI-H) were administered to the patients and re-administered within the space of one week to ensure validation. Psychometric testing was done to ascertain reliability and construct validity. Findings: The Hausa version of the NDI showed good internal consistency (α= 0.741) and test-retest reliability of r=0.84, p< 0.05. The responsiveness analysis revealed a significant relationship (r = 0.47, p=0.01). Factor analysis revealed a 2-factor 10 items structure which explained the variance of 49.7%. Conclusions: The NDI was successfully translated into Hausa language and validated with good psychometric properties.
Greater inadvertent muscle damage in direct anterior approach when compared with the direct superior approach for total hip arthroplasty
Authors: Amanatullah D. F. , Masini M. A. , Roger D. J. , Pagnano M. W. 
Published: August 2016

AimsWe wished to quantify the extent of soft-tissue damage sustained during minimally invasive total hip arthroplasty through the direct anterior (DA) and direct superior (DS) approaches.Materials and MethodsIn eight cadavers, the DA approach was performed on one side, and the DS approach on the other, a single brand of uncemented hip prosthesis was implanted by two surgeons, considered expert in their surgical approaches. Subsequent reflection of the gluteus maximus allowed the extent of muscle and tendon damage to be measured and the percentage damage to each anatomical structure to be calculated.ResultsThe DA approach caused substantially greater damage to the gluteus minimus muscle and tendon when compared with the DS approach (t-test, p = 0.049 and 0.003, respectively). The tensor fascia lata and rectus femoris muscles were damaged only in the DA approach. There was no difference in the amount of damage to the gluteus medius muscle and tendon, piriformis tendon, obturator internus tendon, obturator externus tendon or quadratus femoris muscle between approaches. The posterior soft-tissue releases of the DA approach damaged the gluteus minimus muscle and tendon, piriformis tendon and obturator internus tendon.ConclusionThe DS approach caused less soft-tissue damage than the DA approach. However the clinical relevance is unknown. Further clinical outcome studies, radiographic evaluation of component position, gait analyses and serum biomarker levels are necessary to evaluate and corroborate the safety and efficacy of the DS approach. Cite this article: Bone Joint J 2016;98-B1036–42.
Antibiotic-loaded bone void filler accelerates healing in a femoral condylar rat model
Authors: Shiels S. M. , Cobb R. R. , Bedigrew K. M. , Ritter G. , Kirk J. F. , Kimbler A. , Finger Baker I. , Wenke J. C. 
Published: August 2016

AimsDemineralised bone matrix (DBM) is rarely used for the local delivery of prophylactic antibiotics. Our aim, in this study, was to show that a graft with a bioactive glass and DBM combination, which is currently available for clinical use, can be loaded with tobramycin and release levels of antibiotic greater than the minimum inhibitory concentration for Staphylococcus aureus without interfering with the bone healing properties of the graft, thus protecting the graft and surrounding tissues from infection.Materials and MethodsAntibiotic was loaded into a graft and subsequently evaluated for drug elution kinetics and the inhibition of bacterial growth. A rat femoral condylar plug model was used to determine the effect of the graft, loaded with antibiotic, on bone healing.ResultsWe found that tobramycin loaded into a graft composed of bioglass and DBM eluted antibiotic above the minimum inhibitory concentration for three days in vitro. It was also found that the antibiotic loaded into the graft produced no adverse effects on the bone healing properties of the DBM at a lower level of antibiotic.ConclusionThis antibiotic-loaded bone void filler may represent a promising option for the delivery of local antibiotics in orthopaedic surgery. Cite this article: Bone Joint J 2016;98-B:1126–31.
Surface Modification of Smectite Clays Via Ion-Dipole Bonding
Authors: Beall Gary W. 
Published: August 2016

Abstract
Smectite clays have been modified with organic onium ions for more than 60 y and are important in a diverse range of industries including oil-well drilling, paint, grease, ink, cosmetics, environmental clean-up, polymer nanocomposites, and pharmaceuticals. The number of commercially available onium ions limits the variety of surface modifications that can be made. A substantial amount of research has been conducted on other methods of organic modification of smectite clays in order to remedy this situation. One method that has seen increased attention is the use of ion-dipole-bonding of organic molecules, oligomers, or polymers to the exchangeable cation on the clay surface. Utilizing this method, a unique class of surface-modified clays can be produced. In some cases self-assembly of certain organic molecules has been discovered in which the molecules form rigid posts around each cation on the surface. The intercalation/exfoliation behavior of smectite clays modified via ion-dipole bonding utilizing various small organic molecules and selected polar polymers is discussed here. The types of organic molecules that can be utilized to surface modify smectites is discussed in detail as are the characteristics of the complexes that are formed.
Cytotype Regulation Facilitates Repression of Hybrid Dysgenesis by Naturally OccurringKPElements inDrosophila melanogaster
Authors: Simmons Michael J , Grimes Craig D , Czora Cody S 
Published: August 2016

AbstractP elements inserted in the Telomere Associated Sequences (TAS) at the left end of the X chromosome are determiners of cytotype regulation of the entire P family of transposons. This regulation is mediated by Piwi-interacting (pi) RNAs derived from the telomeric P elements (TPs). Because these piRNAs are transmitted maternally, cytotype regulation is manifested as a maternal effect of the TPs. When a TP is combined with a transgenic P element inserted at another locus, this maternal effect is strengthened. However, when certain TPs are combined with transgenes that contain the small P element known as KP, stronger regulation arises from a zygotic effect of the KP element. This zygotic effect is observed with transgenic KP elements that are structurally intact, as well as with KP elements that are fused to an ancillary promoter from the hsp70 gene. Zygotic regulation by a KP element occurs only when a TP was present in the maternal germ line, and it is more pronounced when the TP was also present in the grand-maternal germ line. However, this regulation does not require zygotic expression of the TP. These observations can be explained if maternally transmitted piRNAs from TPs enable a polypeptide encoded by KP elements to repress P element transposition in zygotes that contain a KP element. In nature, repression by the KP polypeptide may therefore be facilitated by cytotype-mediating piRNAs.
Transcriptomic Analysis of Differentially Expressed Genes During Larval Development ofRapana venosaby Digital Gene Expression Profiling
Authors: Song Hao , Yu Zheng-Lin , Sun Li-Na , Xue Dong-Xiu , Zhang Tao , Wang Hai-Yan 
Published: August 2016

AbstractDuring the life cycle of shellfish, larval development, especially metamorphosis, has a vital influence on the dynamics, distribution, and recruitment of natural populations, as well as seed breeding. Rapana venosa, a carnivorous gastropod, is an important commercial shellfish in China, and is an ecological invader in the United States, Argentina, and France. However, information about the mechanism of its early development is still limited, because research in this area has long suffered from a lack of genomic resources. In this study, 15 digital gene expression (DGE) libraries from five developmental stages of R. venosa were constructed and sequenced on the IIIumina Hi-Sequation 2500 platform. Bioinformaticsanalysis identified numerous differentially and specifically expressed genes, which revealed that genes associated with growth, nervous system, digestive system, immune system, and apoptosis participate in important developmental processes. The functional analysis of differentially expressed genes was further implemented by gene ontology, and Kyoto encyclopedia of genes and genomes enrichment. DGE profiling provided a general picture of the transcriptomic activities during the early development of R. venosa, which may provide interesting hints for further study. Our data represent the first comparative transcriptomic information available for the early development of R. venosa, which is a prerequisite for a better understanding of the physiological traits controlling development.
Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels inDrosophila melanogaster
Authors: Remnant Emily J , Williams Adam , Lumb Chris , Yang Ying Ting , Chan Janice , Duchêne Sebastian , Daborn Phillip J , Batterham Philip , Perry Trent 
Published: August 2016

AbstractLigand-gated chloride channels have established roles in inhibitory neurotransmission in the nervous systems of vertebrates and invertebrates. Paradoxically, expression databases in Drosophila melanogaster have revealed that three uncharacterized ligand-gated chloride channel subunits, CG7589, CG6927, and CG11340, are highly expressed in nonneuronal tissues. Furthermore, subunit copy number varies between insects, with some orders containing one ortholog, whereas other lineages exhibit copy number increases. Here, we show that the Dipteran lineage has undergone two gene duplications followed by expression-based functional differentiation. We used promoter-GFP expression analysis, RNA-sequencing, and in situ hybridization to examine cell type and tissue-specific localization of the three D. melanogaster subunits. CG6927 is expressed in the nurse cells of the ovaries. CG7589 is expressed in multiple tissues including the salivary gland, ejaculatory duct, malpighian tubules, and early midgut. CG11340 is found in malpighian tubules and the copper cell region of the midgut. Overexpression of CG11340 increased sensitivity to dietary copper, and RNAi and ends-out knockout of CG11340 resulted in copper tolerance, providing evidence for a specific nonneuronal role for this subunit in D. melanogaster. Ligand-gated chloride channels are important insecticide targets and here we highlight copy number and functional divergence in insect lineages, raising the potential that order-specific receptors could be isolated within an effective class of insecticide targets.
The Rate and Spectrum of Spontaneous Mutations in Mycobacterium smegmatis, a Bacterium Naturally Devoid of the Postreplicative Mismatch Repair Pathway
Authors: Kucukyildirim Sibel , Long Hongan , Sung Way , Miller Samuel F , Doak Thomas G , Lynch Michael 
Published: August 2016

Abstract
Mycobacterium smegmatis is a bacterium that is naturally devoid of known postreplicative DNA mismatch repair (MMR) homologs, mutS and mutL, providing an opportunity to investigate how the mutation rate and spectrum has evolved in the absence of a highly conserved primary repair pathway. Mutation accumulation experiments of M. smegmatis yielded a base-substitution mutation rate of 5.27 × 10−10 per site per generation, or 0.0036 per genome per generation, which is surprisingly similar to the mutation rate in MMR-functional unicellular organisms. Transitions were found more frequently than transversions, with the A:T→G:C transition rate significantly higher than the G:C→A:T transition rate, opposite to what is observed in most studied bacteria. We also found that the transition-mutation rate of M. smegmatis is significantly lower than that of other naturally MMR-devoid or MMR-knockout organisms. Two possible candidates that could be responsible for maintaining high DNA fidelity in this MMR-deficient organism are the ancestral-like DNA polymerase DnaE1, which contains a highly efficient DNA proofreading histidinol phosphatase (PHP) domain, and/or the existence of a uracil-DNA glycosylase B (UdgB) homolog that might protect the GC-rich M. smegmatis genome against DNA damage arising from oxidation or deamination. Our results suggest that M. smegmatis has a noncanonical Dam (DNA adenine methylase) methylation system, with target motifs differing from those previously reported. The mutation features of M. smegmatis provide further evidence that genomes harbor alternative routes for improving replication fidelity, even in the absence of major repair pathways.
rDNA Copy Number Variants Are Frequent Passenger Mutations in Saccharomyces cerevisiae Deletion Collections and de Novo Transformants
Authors: Kwan Elizabeth X , Wang Xiaobin S , Amemiya Haley M , Brewer Bonita J , Raghuraman M K 
Published: August 2016

Abstract
The Saccharomyces cerevisiae ribosomal DNA (rDNA) locus is known to exhibit greater instability relative to the rest of the genome. However, wild-type cells preferentially maintain a stable number of rDNA copies, suggesting underlying genetic control of the size of this locus. We performed a screen of a subset of the Yeast Knock-Out (YKO) single gene deletion collection to identify genetic regulators of this locus and to determine if rDNA copy number correlates with yeast replicative lifespan. While we found no correlation between replicative lifespan and rDNA size, we identified 64 candidate strains with significant rDNA copy number differences. However, in the process of validating candidate rDNA variants, we observed that independent isolates of our de novo gene deletion strains had unsolicited but significant changes in rDNA copy number. Moreover, we were not able to recapitulate rDNA phenotypes from the YKO yeast deletion collection. Instead, we found that the standard lithium acetate transformation protocol is a significant source of rDNA copy number variation, with lithium acetate exposure being the treatment causing variable rDNA copy number events after transformation. As the effects of variable rDNA copy number are being increasingly reported, our finding that rDNA is affected by lithium acetate exposure suggested that rDNA copy number variants may be influential passenger mutations in standard strain construction in S. cerevisiae.