bluuebunny/crossref_metadata_2025_split huggingface dataset:
Orai1 Plays a Crucial Role in Central Sensitization by Modulating Neuronal Excitability
Authors: Dou Yannong , Xia Jingsheng , Gao Ruby , Gao Xinghua , Munoz Frances M. , Wei Dongyu , Tian Yuzhen , Barrett James E. , Ajit Seena , Meucci Olimpia , Putney James W. , Dai Yue , Hu Huijuan 
Published: December 2017

Pathological pain is a common and debilitating condition that is often poorly managed. Central sensitization is an important mechanism underlying pathological pain. However, candidate molecules involved in central sensitization remain unclear. Store-operated calcium channels (SOCs) mediate important calcium signals in nonexcitable and excitable cells. SOCs have been implicated in a wide variety of human pathophysiological conditions, including immunodeficiency, occlusive vascular diseases, and cancer. However, the role of SOCs in CNS disorders has been relatively unexplored. Orai1, a key component of SOCs, is expressed in the human and rodent spinal cord dorsal horn, but its functional significance in dorsal horn neurons is poorly understood. Here we sought to explore a potential role of Orai1 in the modulation of neuronal excitability and A-type potassium channels involved in pain plasticity. Using both male and female Orai1 knock-out mice, we found that activation of Orai1 increased neuronal excitability and reduced A-type potassium channels via the protein kinase C–extracellular signal-regulated protein kinase (PKC–ERK) pathway in dorsal horn neurons. Orai1 deficiency significantly decreased acute pain induced by noxious stimuli, nearly eliminated the second phase of formalin-induced nociceptive response, markedly attenuated carrageenan-induced ipsilateral pain hypersensitivity and abolished carrageenan-induced contralateral mechanical allodynia. Consistently, carrageenan-induced increase in neuronal excitability was abolished in the dorsal horn from Orai1 mutant mice. These findings uncover a novel signaling pathway involved in the pain process and central sensitization. Our study also reveals a novel link among Orai1, ERK, A-type potassium channels, and neuronal excitability.SIGNIFICANCE STATEMENTOrai1 is a key component of store-operated calcium channels (SOCs) in many cell types. It has been implicated in such pathological conditions as immunodeficiency, autoimmunity, and cancer. However, the role of Orai1 in CNS disorders remains poorly understood. The functional significance of Orai1 in neurons is elusive. Here we demonstrate that activation of Orai1 modulates neuronal excitability and Kv4-containing A-type potassium channels via the protein kinase C–extracellular signal-regulated protein kinase (PKC–ERK) pathway. Genetic knock-out of Orai1 nearly eliminates the second phase of formalin-induced pain and markedly attenuates carrageenan-induced pain hypersensitivity and neuronal excitability. These findings reveal a novel link between Orai1 and neuronal excitability and advance our understanding of central sensitization.
The Primary Role of Flow Processing in the Identification of Scene-Relative Object Movement
Authors: Rushton Simon K. , Niehorster Diederick C. , Warren Paul A. , Li Li 
Published: December 2017

Retinal image motion could be due to the movement of the observer through space or an object relative to the scene. Optic flow, form, and change of position cues all provide information that could be used to separate out retinal motion due to object movement from retinal motion due to observer movement. In Experiment 1, we used a minimal display to examine the contribution of optic flow and form cues. Human participants indicated the direction of movement of a probe object presented against a background of radially moving pairs of dots. By independently controlling the orientation of each dot pair, we were able to put flow cues to self-movement direction (the point from which all the motion radiated) and form cues to self-movement direction (the point toward which all the dot pairs were oriented) in conflict. We found that only flow cues influenced perceived probe movement. In Experiment 2, we switched to a rich stereo display composed of 3D objects to examine the contribution of flow and position cues. We moved the scene objects to simulate a lateral translation and counter-rotation of gaze. By changing the polarity of the scene objects (from light to dark and vice versa) between frames, we placed flow cues to self-movement direction in opposition to change of position cues. We found that again flow cues dominated the perceived probe movement relative to the scene. Together, these experiments indicate the neural network that processes optic flow has a primary role in the identification of scene-relative object movement.SIGNIFICANCE STATEMENTMotion of an object in the retinal image indicates relative movement between the observer and the object, but it does not indicate its cause: movement of an object in the scene; movement of the observer; or both. To isolate retinal motion due to movement of a scene object, the brain must parse out the retinal motion due to movement of the eye (“flow parsing”). Optic flow, form, and position cues all have potential roles in this process. We pitted the cues against each other and assessed their influence. We found that flow parsing relies on optic flow alone. These results indicate the primary role of the neural network that processes optic flow in the identification of scene-relative object movement.
A mellkassebészeti műtéti teherbíró képesség megítélése, perioperatív légzésrehabilitáció
Authors: Vágvölgyi Attila , Rozgonyi Zsolt , Vadász Pál , Varga János Tamás 
Published: December 2017

Abstract: Introduction: Besides the oncology and operative surgical technics, functional aspects influence the operability of lung cancer. Preoperative risk stratification, evaluation of postoperative complications needs to be considered. Aim: To review international literature and experiences of our institute. Method: We focused the literature of risk stratification of thoracic surgery. Lung function, lung mechanics, chest kinematics, exercise physiology were considered. Effectiveness of pulmonary rehabilitation for cardiovascular system, lung mechanics, muscles, exercise capacity and quality of life were evaluated. Laboratory parameters, comorbidities, obesity, cachexia, smoking cessation were considered. Results: Elevated blood sugar, kidney function, reduced albumin level increased the risk. COPD, sleep apnoea, heart failure, obesity and cachexia influences the outcome. Smoking cessation may reduce postoperative complications. Controlled breathing technics, chest wall mobilization, training have favourable effects. Psychosocial support and dietetics are important. Conclusions: Risk stratification is supported by laboratory parameters, lung function, oxygen uptake and comorbidities. Pulmonary rehabilitation can improve functionality and quality of life. Orv Hetil. 2017; 158(50): 1989–1997.
A D-dimer laboratóriumi eredményeinek és klinikai értékelésének elemzése
Authors: Jákó János 
Published: December 2017

Abstract: D-dimer is a product of the enzymatic degradation of the fibrinogen-fibrin molecule, and its existence is demonstrable in circulation. The test based limits may be considered as normal values. It was first thought to be a product of coagulation, then a product of lysis. High-concentration D-dimer in blood detected in thromboembolic diseases is considered to be of diagnostic value. In cases where thromboembolism was ruled out despite elevated titres but heparin (LMWH) or CLOPIDOGREL was given as a cautionary measure, we found that D-dimer values remained elevated. This finding means that in vivo coagulation is not a precondition to D-dimer formation. Analysis of such cases uncovers liver or kidney disease in the background, but old age may also be a factor. Often elevated ferritin levels were observed ‘in parallel’ with elevated D-dimer values. These findings lead us to presume an enzymatic degradation process of ‘elderly’ protein molecules, which is universally applicable. Orv Hetil. 2017; 158(50): 1971–1976.
DIFERENTES ÁREAS ADESIVAS AFETAM A RESISTÊNCIA DE UNIÃO AO MICROCISALHAMENTO?
Authors: Thiesen Kevelin Poliana Palma Rigo , Ribas Mariana Macedo , Andrade Guilherme Schmitt de , Nahsan Flávia Pardo Salata , Schmitt Vera Lucia , Naufel Fabiana Scarparo 
Published: December 2017

Quanto menor a superfície da área, maior a resistência de união, pois, espécimes com pequena área de superfície apresentam melhor distribuição de estresse, bem como reduzido número de defeitos internos. O objetivo deste estudo foi verificar a resistência de união ao microcisalhamento de espécimes com dois diferentes diâmetros, 0.55 mm e 0.76 mm. 40 fatias de cerâmica Suprinity, com 1,3 mm de espessura, polidas em lixa #600, foram divididas aleatoriamente em dois grupos (n=20). Em cada fatia, quatro áreas adesivas foram delimitadas por fita adesiva, sendo então fixadas as matrizes circulares. Os espécimes foram condicionados com ácido fluorídrico a 5% (FGM) por 20 s, lavados e secos; então silanizados (RelyX Ceramic Primer - 3M ESPE) e secos com jato de ar. As matrizes foram preenchidas com cimento resinoso RelyX U200 3M ESPE e fotopolimerizadas por 100 s. Após 24 h em água deionizada a 37o C, os espécimes foram submetidos ao teste de microcisalhamento sob velocidade de 0,5 mm/min. Os dados normais e homogêneos foram submetidos à ANOVA para o experimento inteiramente casualizado, não exibindo diferença significativa (p =0,62) entre as duas áreas avaliadas – 23,74±4,49 e 24,85±4,41, respectivamente para as áreas 0,55 e 0,76 mm. Concluímos que, não há diferença na resistência de união ao microcisalhamento quando se utilizam as diferentes áreas adesivas estudadas.
PERBANDINGAN PENERAPAN PEMBELAJARAN KOOPERATIF TIPE JIGSAW DENGAN TAI TERHADAP HASIL BELAJAR RANAH KOGNITIF KELAS VIII [A COMPARISON OF THE IMPLEMENTATION OF COOPERATIVE LEARNING METHODS JIGSAW AND TAI ON COGNITIVE LEARNING OUTCOMES OF GRADE 8 STUDENTS]
Authors: Susilawati Yuni Eka , Silalahi Desri Kristina , Saragih Melda Jaya 
Published: December 2017

<p>One of the factors affecting student learning outcomes is the learning process in the classroom. A teacher-centered learning process provides little learning experience for students. Student-centered learning needs to be developed so that students may experience meaningful learning and achieve good outcomes. The purpose of this study was to see the different cognitive learning outcomes caused by the implementation of two cooperative learning methods: jigsaw and TAI. The research method used is a quantitative quasi experiment with Nonequivalent Control Group Design. Student learning outcomes were measured by a post test. The difference in the learning outcomes were tested using a t-test. The research concludes that there is a significant difference of cognitive learning outcomes between students who are given cooperative learning jigsaw type (mean 43.14) and TAI (mean 47.85).</p><p><strong>ABSTRAK BAHASA INDONESIA: </strong>Salah satu faktor yang memengaruhi hasil belajar siswa adalah proses pembelajaran di kelas. Pembelajaran yang berpusat kepada guru cenderung memberikan sedikit pengalaman belajar kepada siswa. Pembelajaran yang berpusat kepada siswa perlu dikembangkan agar siswa dapat mengalami pembelajaran yang bermakna dan mendapatkan hasil belajar yang baik. Tujuan penelitian ini untuk melihat perbedaan hasil belajar kognitif karena penerapan dua jenis pembelajaran kooperatif yaitu <em>jigsaw</em> dan <em>TA</em>I pada dua kelas yang berbeda. Metode penelitian yang digunakan adalah kuantitatif <em>quasi eksperimen </em>dengan desain penelitian <em>Nonequivalent Control Group Design</em>. Hasil belajar siswa diukur menggunakan nilai <em>post-test</em>. Perbedaan hasil belajar dianalisis menggunakan uji t. Hasil penelitian menunjukkan bahwa terdapat perbedaan signifikan (hasil belajar ranah kognitif antara siswa yang diberikan pembelajaran kooperatif tipe <em>jigsaw</em> (mean 43.14) dengan tipe <em>TAI</em> (mean 47.85).</p>
J-class abelian semigroups of matrices on ℝ
n
Authors: Marzougui Habib 
Published: December 2017

Abstract
We establish, for finitely generated abelian semigroups G of matrices on ℝ
n
, and by using the extended limit sets (the J-sets), the following equivalence analogous to the complex case: (i) G is hypercyclic, (ii) JG
(v
η) = ℝ
n
for some vector v

η
given by the structure of G, (iii)
G(vη
) = ℝ
n
. This answer a question raised by the author. Moreover we construct for any n = 2 an abelian semigroup G of GL(n, ℝ) generated by n + 1 diagonal matrices which is locally hypercyclic (or J-class) but not hypercyclic and such that J
G
(ek
) = ℝ
n
for every k = 1,…, n, where (e
1,…, e

n
) is the canonical basis of ℝ
n
. This gives a negative answer to a question raised by Costakis and Manoussos
Accounting for Fluid-Property Variations in Temperature-Transient Analysis
Authors: Mao Yilin , Zeidouni Mehdi 
Published: December 2017

Summary
Significant fluid-property variation can be induced with pressure and temperature dynamics in the reservoir associated with oil production. The existing analytical solutions for temperature-transient analysis (TTA) generally assume constant fluid properties, which can be invalid especially for cases of high drawdown and strong temperature signals. In this study, we present a method to account for the fluid-property variations in TTA. The method introduces corrections on fluid-property values as input for analytical solutions, considering the quasilinear behavior of the temporal Joule-Thomson effect on a semilog plot. The corrections are performed on four identified fluid properties in an iterative manner, which can be easily implemented in available temperature-analysis procedures. To validate the developed approach, we model drawdown- and buildup-transient-temperature signals with the fluid-property correction method for nondamaged and damaged reservoirs under different production rates and reservoir-fluid compositions. The analytical modeling results are compared with numerical simulations. In addition, by finding the dominating fluid property, a simplified approach of property correction is presented. Through application to example problems, we show that using the fluid-property correction method presented here can improve the permeability estimations by 60% for the conditions considered in this paper. We present a modified method for damaged reservoirs, which results in an additional 25% improvement on the permeability estimations. With these improvements, the applicability of TTA using analytical solutions can be extended from cases with limited sandface-temperature signals of a few degrees Celsius to stronger signals of 20 to 30°C.
A importância das Tecnologias de Comunicação e Informação (TIC) como ferramenta pedagógica na Educação Infantil e nas Séries Iniciais do Ensino Fundamental
Authors: De Souza Jean André , Cirilo Eliene Maciel , Da Silva Nathalia Diogo , Ricci Maria Fernanda Caravana de Castro Moraes , Rodrigues Marinéa Figueira 
Published: December 2017

Esta pesquisa tem como objetivo investigar a importância das Tecnologias de Comunicação e Informação (TIC) como ferramenta pedagógica no processo ensino aprendizagem na Educação Infantil e nas Séries Iniciais do Ensino Fundamental. Para tanto, realizou-se uma pesquisa de cunho bibliográfico, baseada em renomados autores no assunto, a saber: Almeida (2004), Alonso (2012), Barros (2005) (Dowbor (2001), Thomé (2015) dentre outros. As TIC auxiliam a prática docente, possibilitando o professor trabalhar com diversos tipos de ferramentas e aplicativos que tornarão suas aulas mais interessantes e motivadoras e a aprendizagem do aluno mais produtiva e interativa.Palavras chave: Educação; Ensino e Aprendizagem; Tecnologia da Informação e Comunicação. Abstract:This research aims to investigate the importance of Communication and Information Technologies (ICT) as a pedagogical tool in the process of teaching learning in Early Childhood Education and Early Years of Primary Education. To that end, a bibliographic research was carried out, based on renowned authors in the subject, namely: Almeida (2004), Alonso (2012), Barros (2005) (Dowbor (2001), Thomé (2015) among others. ICT help teachers, enabling the teacher to work with different types of tools and applications that will make their classes more interesting and motivating and student learning more productive and interactive.Keywords: Education; Teaching and learning; Technology of Information and Communication.
Postoperative Evaluation of Health-Related Quality-of-Life (HRQoL) of Patients With Lumbar Degenerative Spondylolisthesis After Instrumented Posterolateral Fusion (PLF): A prospective Study With a 2-Year Follow-Up
Authors: Kapetanakis S. , Gkasdaris G. , Thomaidis T. , Charitoudis G. , Nastoulis E. , Givissis P. 
Published: December 2017

Background:
Several studies have compared instrumented PLF with other surgical approaches in terms of clinical outcomes, however little is known about the postoperative HRQoL of patients, especially as regards to degenerative spondylolisthesis.

Methods:
A group of 62 patients, 30 women (48,4%) and 32 men (51,6%) with mean age 56,73 (SD +/- 9,58) years old, were selected to participate in a 2-year follow-up. Their pain was assessed via the visual analogue scale (VAS) for low back pain (VASBP) and leg pain (VASLP) separately. Their HRQoL was evaluated by the Short Form (36) Health Survey (SF-36). Both scales, VAS and SF36, were measured and re-assessed at 10 days, 1 month, 3 months, 6 months, 12 months and 2 years.

Results:
VASBP, VASLP and each parameter of SF36 presented statistically significant improvement (p<0.01). VASBP, VASLP and SF36 scores did not differ significantly between men and women (p≥0.05). The most notable amelioration of VASBP, VASLP was observed within the first 10 days and the maximum improvement within the first 3 months. From that point, a stabilization of the parameters was observed. The majority of SF36 parameters, and especially PF (physical functioning) and BP (bodily pain), presented statistically significant improvement within the follow up depicting a very similar improvement pattern to that of VAS.

Conclusion:
We conclude that instrumented PLF ameliorates impressively the HRQoL of patients with degenerative spondylolisthesis after 2 years of follow-up, with pain recession being the most crucial factor responsible for this improvement.
Neuvotteluja sosiaalisen median arkkitehtuurisesta vallasta <br>Käyttäjien ja ei-käyttäjien suhtautuminen Facebookiin teknologiavälitteisenä tilana
Authors: Saariketo Minna 
Published: December 2017

Facebookin kaltaisten verkkoympäristöjen käytön nivoutuminen osaksi arkea herättää kysymyksen siitä, miten tekniset alustat muovaavat ihmisten toimintaa ja miten ihmiset ymmärtävät näiden alustojen vaikuttavan toiminnan mahdollisuuksiinsa. Lähestyn tätä kysymystä soveltamalla Stuart Hallin tunnettua sisäänkoodaus–uloskoodaus-mallia Facebookin käyttäjien ja ei-käyttäjien ryhmäkeskusteluiden analyysiin. Esitän Hallin mallia mukaillen, että sosiaalista mediaa tutkittaessa on syytä ottaa huomioon samanaikaisesti se, miten sivustot rakentuvat ja ensisijaistavat merkityksiä sekä miten ihmiset ymmärtävät sivustot ja niiden merkityksen toiminnalleen. Empiirisessä analyysissani hahmottelen viisi erilaista neuvotteluasemaa suhteessa Facebookiin. Nämä ovat hyväksyvä, vähättelevä, normatiivinen, tyytyvä ja torjuva. Ryhmäkeskustelijat ensisijaistivat neuvotteluissaan Facebookin tarjoamat mahdollisuudet yhteydenpitoon. Facebookin yhteyksiä ohjaavaa luonnetta ja alustan arkkitehtuurista valtaa ei pidetty oman toiminnan kannalta merkityksellisenä. Poikkeuksen muodosti torjuva neuvotteluasema, johon asettui ei-käyttäjiä sekä käytön lopettaneita tai lopettamista harkitsevia käyttäjiä. Tutkimus antaakin viitteitä siitä, että alustojen arkistuminen ja myönteiset käyttökokemukset saavat internetin toimintaympäristöjen materiaalis-taloudelliset reunaehdot näyttäytymään merkityksettöminä, eikä niitä tunnu mielekkäältä pohtia. Tietojen keräämisen ja myymisen perustuva toimintamalli luonnollistuu eikä kaupallista mallia haastaville vaihtoehdoille nähdä tarvetta.
Amatöörikuvien läheisyys kriisiuutisissa toimittajien ja yleisön tulkitsemina
Authors: Ahva Laura , Pantti Mervi 
Published: December 2017

Ajatus ”lähelle pääsemisestä” toistuu journalistisissa kolumneissa, juhlapuheissa ja strategiapapereissa. Läheisyydestä on tullut journalistinen strategia. Yksi uusista keinoista tuottaa journalismiin läheisyyttä on monenlaisen yleisöaineiston hyödyntäminen. Tässä artikkelissa keskitymme erityisesti kriisi- ja onnettomuusuutisissa julkaistuun kuvalliseen yleisöaineistoon, eli niin sanottuihin amatöörikuviin. Tarkastelemme amatöörikuvien läheisyyteen liittyviä merkityksiä sekä toimittajien että yleisön näkökulmasta. Näissä tulkinnoissa tulee esiin, että amatöörikuvien läheisyys perustuu etenkin niiden ajallis-tilalliseen ja tunteelliseen ulottuvuuteen. Yleisö ottaa kuitenkin toimittajia enemmän etäisyyttä siihen tapaan, jolla näitä ulottuvuuksia on koetettu uutisorganisaatioissa hyödyntää strategisesti.
Aktivoitu yleisö Suomen Big Brotherin internet-keskustelupalstalla
Authors: Hautakangas Mikko 
Published: December 2017

Artikkelissa tarkastellaan yleisön, tekstin ja tuotannon välisiä suhteita. Aineistona käytetään Suomen Big Brotherin virallisella internet-keskustelupalstalla käytyä keskustelua. Big Brotherin kaltaiset osallistavat monimediaformaatit tarjoavat yleisölle mahdollisuuden osallistua mediatekstin muotoutumiseen ja jopa vaikuttaa suoraan tuotannon toimiin. Tällainen vuorovaikutteisuus tuo yleisön ja tuotannon toimijuudet lähemmäksi toisiaan, mikä voi aiheuttaa erityispiirteitä yleisön suhtautumi-sessa tekstiin.
Artikkelissa osallistutaan keskusteluun kulttuurintutkimuksessa käytetystä ”aktiivisen yleisön” käsitteestä ja tarkastellaan Big Brotherin yleisöä aktivoidun yleisön käsitteen kautta. Tämän uuden käsitteen avulla pyritään kiinnittämään huomio erityisesti yleisön ja tekstin suhteisiin sekä näihin suhteisiin liittyviin molemminpuolisiin panostuksiin: ajatus aktivoidusta yleisöstä sisältää sekä yleisön aktiivisen toimijuuden tekstin ja sen merkitysten muotoutumisessa että tekstin aktiivisen toimijuuden, pyrkimyksen kutsua yksilöitä osaksi tekstiä ja panostamaan omaan yleisöyteensä.
Back to the Future: Sparta, Athena, and the battle for the Arab public sphere
Authors: Cherkaoui Tarek 
Published: December 2017

Al Jazeera (AJ) has been a defining feature in developing news media in the Middle East and beyond. The satellite-broadcasting network has played a leading role in bringing stories and perspectives that other international media do not always cover, if at all. More importantly, it has been a champion for democracy and human rights in the Middle East, thereby provoking the ire of Arab autocratic rulers, which went to great length to silence the Qatar-based television news network. The latest Gulf Crisis, in which four countries (Saudi Arabia, the United Arab Emirates, Bahrain, and Egypt) blockaded Qatar in July 2017, is another attempt to silence this media institution and peg back the region to the pre-Arab Spring era. The anti-Qatar quartet issued an ultimatum of 13 demands to be fulfilled within ten days. The list included paying reparations, shutting down Al Jazeera, curbing bilateral relations with Iran, closing a Turkish military base, and submitting to monthly external compliance checks. However, the crisis could be a blessing in disguise for Qatar and the network in its campaign for greater freedom of expression in the Middle East. This article analyses the crisis from a media political economy perspective.