bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous Splenic Rupture Caused by Scrub Typhus
Authors: Thipmontree Wilawan , Suwattanabunpot Kittipong , Supputtamonkol Yupin 
Published: October 2016

Abstract
Spontaneous rupture of the spleen is rarely described as a complication of scrub typhus infection. We report a previously healthy 74-year-old Thai female farmer who presented in Nakhon Ratchasima, Thailand, with a history of fever and malaise for 5 days, followed by abdominal pain for 1 day. An exploratory laparotomy was performed due to peritonitis. Operative findings revealed a ruptured spleen and hemoperitoneum. A splenectomy was performed afterward. Scrub typhus was confirmed by a 4-fold increase of IgM titer using an indirect immunofluorescence antibody assay and a positive result from the polymerase chain reaction targeting the 47- and 56-kDa genes in Orientia tsutsugamushi. She responded well to intravenous chloramphenicol and defervesced within 24 hours without any complication.
Juvenile Probation Professionals’ Perceptions of Community-Based Probation Practices
Authors: Beneby Darren R. 
Published: October 2016

<p>Recent budget restraints and heightened concerns for juvenile offenders’ safety and well-being have compelled juvenile justice policymakers and practitioners to implement community-based approaches for reducing juvenile recidivism. This paper explores whether individual, organizational, and attitudinal factors influence juvenile probation professionals’ perceptions of the community-based probation (CBP) model, a supervision strategy that emphasizes establishing community partnerships to rehabilitate youths. Seventy-one juvenile probation professionals working in probation agencies across Texas completed questionnaires asking them about their perceptions of CBP and its impact on current juvenile offending trends. Results of regression analyses revealed that rehabilitation-oriented juvenile probation professionals were more likely to attribute current decreases in juvenile offending to CBP and more likely to believe that CBP does not endanger public safety. Interestingly, the age of juvenile probation professionals was correlated with an increased probability that professionals believed that CBP poses no threat to public safety. The article concludes with a discussion of the implications for supervision strategies and directions for future research. </p>
Zika Vírus
Authors: Bastos Cynthia Molina , D'Avila Otávio Pereira , Umpierre Roberto Nunes , Rodrigues Marcelo Goncalves , Harzheim Erno 
Published: October 2016

Michele, 32 anos, procura a Unidade de Saúde por manchas na pele, há 24 horas, levemente pruriginosas. A paciente retornou de uma viagem há dois dias. Viajou por cidades do nordeste brasileiro durante dez dias. Ela suspeita de que a reação alérgica se deve ao protetor solar, que pode ter causado a irritação na sua pele. Conforme relata, no último dia das férias, precisou comprar um produto novo, de uma marca que nunca havia utilizado. Além disso, refere que o quadro alérgico está tão importante que não colocou as lentes de contato, devido ao olho levemente vermelho, sem prurido e com discreto lacrimejamento e já iniciou o colírio para conjuntivite alérgica, corticoide tópico nasal e loratadina 10 mg.Quando questionada em relação a outros sintomas associados, refere cansaço, dizendo que adorou a viagem, mas que retornar de férias é sempre mais cansativo. Afirma que não se alimentou direito nos últimos dois dias, o voo durou mais de 12 horas devido as conexões aéreas e que ela está com dor no corpo, mais importantes nas articulações, “toda dolorida”. Cefaleia e sensação de peso na cabeça e malestar. Não sabe se teve febre, pois não aferiu, entretanto, quando questionada acha possível. Nega alterações no hábito intestinal ou urinárias. Refere tosse e discreta secreção hialina nasal, após ter chegado ao seu apartamento, que ficou fechado por dez dias.Michele é professora universitária, natural de Mossoró, no Rio Grande do Norte, católica, casada. Foi morar na região Sul do país, com seu esposo, após assumir um cargo na universidade local. Eles planejam engravidar no ano de 2016, inclusive realizaram sorologias e esclareceram dúvidas na última consulta na unidade de saúde.Segundo anotações do prontuário médico, a paciente apresenta diversas atopias, com quadros de exacerbação de conjuntivite alérgica, dermatite atópica e rinossinusite alérgica mais importantes no inverno e na primavera. Entretanto, tem bom controle dos sintomas com uso de corticoide tópicos nos meses de inverno e primavera. Uso de anticoncepcional oral.Ao exame físico, a paciente apresenta bom estado geral, eutrófica, temperatura axilar de 37,4 graus, sinais vitais sem alteração. Pele com exantema maculopapular, distribuído por todo corpo, sem descamação, sem preservar áreas específicas. Olhos com hiperemia de conjuntiva, sem secreção aparente. Rinoscopia e oroscopia sem alterações. Ausculta pulmonar limpa. Extremidades perfundidas, aquecidas e sem edema.PERGUNTABaseado na história e exame físico, qual o diagnóstico mais provável?a) Zika Vírus.b) Reação alérgica aguda de etiologia ainda desconhecida.c) Parvovirose.d) Exacerbação da dermatite atópica e da conjuntivite alérgica.
Development and Validation of a Green Analytical Method for the Determination of Norfloxacin in Raw Material by FTIR Spectrophotometry
Authors: Natori Jéssica Sayuri Hisano , Tótoli Eliane Gandolpho , Salgado Hérida Regina Nunes 
Published: October 2016

Abstract
Norfloxacin is a broad-spectrum antimicrobial agent, widely used in humans and animals for the treatment of urinary tract infections. It is a second-generation fluoroquinolone. Several analytical methods to analyze norfloxacin have been described in the literature. However, most of them are complex and require the use of large amounts of organic solvents. This paper describes the development and validation of a green analytical method for the determination of norfloxacin in raw material by FTIR spectrophotometry. This method does not require the use of organic solvents, minimizing waste generation in the process and its environmental impacts. The development of methods that promote the reduction, prevention, or elimination of waste generation has become highly attractive to the pharmaceutical industry because of the growing demand from civil society and government authorities for environmentally friendly products and services. The FTIR spectrophotometry method was validated according to International Conference on Harmonization guidelines, showing adequate linearity (r = 0.9936), precision, accuracy, and robustness. This validated method can be used as an environmentally friendly alternative for the quantification of norfloxacin in raw material in QC routine analysis.
Ethical potentialities on physical education as a vehicle for ethical education through sports
Authors: Ávila da Costa Luísa , McNamee Michael , Lacerda Teresa 
Published: October 2016

Sports occupy an interesting ethical space from a pedagogic point of view, being included in physical education curricula in most Western countries. The approach of physical education to sports as vehicle for ethical education is too limited when it is restricted to their minimal functional, constitutive and regulatory goals. This essay’s aim is to argue the extent to which the ethical potential of physical education can embrace more than functional purposes, or whether that will be neglected in terms of limited educational aspirations. We present data from nineteen exploratory interviews with experienced philosophy, sports and physical education researchers and teachers, from six different nations, concerning the ethical potentiality of physical education. We highlight five ethical themes: (i) the regulatory and normative structure of sports; (ii) the spirit of sports and its internal values; (iii) the right playing/doing of sports; (iv) the overcoming in sports; and (v) sports as an opportunity for a supererogatory ethics as fertile ground for future operationalization of the potential of physical education for ethical education through sports.El deporte ocupa un interesante espacio ético desde un punto de vista pedagógico, integrándose en los curricula de educación física en la mayoría de países occidentales. El planteamiento de la educación física como vehículo de la educación ética es limitado cuando restringido a sus objetivos mínimos funcionales, constitutivos y regulatorios. El objetivo de este estudio es discutir si el potencial ético de la educación física puede ir más allá de los propósitos funcionales, que considerados aisladamente constituyen un desperdicio de la experiencia pedagógica del deporte. Para conseguirlo, presentamos datos de diecinueve entrevistas exploratorias con experimentados investigadores y profesores de filosofía, deporte y educación física relacionadas con las potencialidades éticas de la educación física. La muestra incluye individuos de seis diferentes nacionalidades, cuyo trabajo demuestra preocupaciones con el tema. La argumentación resulta de cinco temáticas principales: (i) Estructura normativa y regulativa del deporte; (ii) El espírito del deporte y sus valores internos; (iii) El bien hacer deportivo; (iv) La superación deportiva; (v) El deporte como oportunidad de una ética supererogatoria como contexto fértil para la concretización del potencial ético de una educación deportiva.
Reflexiones para una educación ético-estética de la belleza como contribución a la dignificación de la persona en el deporte
Authors: Sánchez Pato Antonio , De la Torre Olid Francisco 
Published: October 2016

Desde la teología y la filosofía podemos comprender el concepto de belleza en el deporte ligado a la dignidad humana. Para ello, en este artículo: a) analizamos desde la antropología del cristianismo el lugar del cuerpo y el valor del deporte en la vida del ser humano; b) abordamos la estética intentando comprender la belleza ligada a la dignidad; a continuación, c) proponemos una educación estética donde la belleza ligada al deporte no está exenta del sufrimiento, las limitaciones físicas o psíquicas del individuo, para que seamos capaces de ver más allá de las formas, en orden a respetar y salvaguardar la dignidad de la persona humana; finalmente, d) reflexionamos sobre el concepto de belleza que profesores y entrenadores están trasmitiendo a los alumnos y a los deportistas a través del deporte, proponiendo un modelo en el que cabe el dolor, el sufrimiento, las limitaciones e imperfecciones sin dejar por ello de ser bellos.From theology and philosophy we can understand the concept of beauty in sport linked to human dignity. Therefore, in this article: a) we analyze, from the anthropology of Christianity, the body and the value of sport in the lives of human beings; b) we boarded the aesthetic trying to understand beauty linked to dignity; then c) we propose an aesthetic education where beauty linked to sport is not without suffering, physical or mental limitations of the individual, so that we are able to see beyond the forms, in order to respect and safeguard the dignity of the human person; finally, d) we reflect on the concept of beauty that teachers and coaches are transmitting to students and athletes through sport, proposing a model that fits the pain, suffering, limitations and imperfections while still being beautiful.
Características quantitativas e qualitativas da carcaça de ovinos Santa Inês em função da relação volumoso:concentrado na dieta, com e sem gordura protegida
Authors: De Assis Marques Bênnio Alexandre , De Souza Bonifácio Benicio , De Sousa Nobre Ismael , Figueiredo Batista Luanna , Gonçalves Andrade Evyla Layssa , Morais Pereira Filho José , Fontes Cezar Marcílio , Nunes da Silva Elisângela Maria 
Published: October 2016

Objetivou-se avaliar as características quantitativas e qualitativas da carcaça de ovinos Santa Inês alimentados com diferentes níveis de concentrado e volumoso com e sem gordura protegida, criados em sistema de confinamento no semiárido paraibano. Foram utilizados 30 machos inteiros da raça Santa Inês,em um delineamento em blocos ao acaso, composto por 6 tratamentos e 5 repetições. Os tratamentos consistiram de diferentes níveis de concentrado (40, 50 e 60%), e cada nível foi testado com e sem a adição de 2% de gordura protegida (GP). Ao término do período de confinamento, os animais foram abatidos e após 24 horas, foi realizada a avaliação do músculo Longissimus dorsi. Os resultados foram submetidos à análise de variância e os valores médios comparados pelo teste de Tukey a 5% de probabilidade, utilizando o sistema de análise estatística SAS (2003). A relação 40:60 de volumoso:concentrado promoveu aumento nos rendimentos de carcaça, quente e fria (P<0,05). Para a inclusão de gordura protegida, não se observou diferença significativa entre os tratamentos. A utilização de 50:50 de volumoso:concentrado demonstrou atender às necessidades para a obtenção de carcaça ovina com características desejáveis de qualidade e,por apresentar maior viabilidade econômica no que se refere aos custos de produção, seria a proporção volumoso:concentrado mais recomendada entre as proporções estudadas. A utilização de 2% de GP na dieta não influencia significativamente as características qualitativas e quantitativas da carcaça de ovinos Santa Inês criados em confinamento.
Demonstration of ultraprecision ductile-mode cutting for lithium niobate microring waveguides
Authors: Takigawa Ryo , Higurashi Eiji , Kawanishi Tetsuya , Asano Tanemasa 
Published: October 2016

Abstract
In this paper, the application of the ultraprecision ductile-mode cutting method to the fabrication of microring waveguides in lithium niobate crystal was investigated. Although it was difficult to apply a mechanical cutting method to the fabrication of microring waveguides with smooth sidewalls, it was confirmed that no harmful cutting traces on the machined surface occur with the appropriate movement of the cutting tool. The root-mean-square surface roughness of the resulting sidewall was 6.1 nm, which is sufficiently small to suppress the scattering loss of the circulating light. In addition, the conditions for the ductile-mode cutting of lithium niobate crystal were investigated.
Development of a P((MAA‐co‐NVP)‐g‐EG) Hydrogel Platform for Oral Protein Delivery: Effects of Hydrogel Composition on Environmental Response and Protein Partitioning
Authors: Steichen Stephanie , O'Connor Colleen , Peppas Nicholas A. 
Published: October 2016

Hydrogels based upon terpolymers of methacrylic acid, N‐vinyl pyrrolidone, and poly(ethylene glycol) are developed and characterized for their ability to respond to changes in environmental pH and to partition protein therapeutics of varying molecular weights and isoelectric points. P((MAA‐co‐NVP)‐g‐EG) hydrogels are synthesized with PEG‐based cross‐linking agents of varying length and incorporation densities. The composition is confirmed using FT‐IR spectroscopy and shows peak shifts indicating hydrogen bonding. Scanning electron microscopy reveals microparticles with an irregular, planar morphology. The pH‐responsive behavior of the hydrogels is confirmed under equilibrium and dynamic conditions, with the hydrogel collapsed at acidic pH and swollen at neutral pH. The ability of the hydrogels to partition model protein therapeutics at varying pH and ionic strength is evaluated using three model proteins: insulin, porcine growth hormone, and ovalbumin. Finally, the microparticles are evaluated for adverse interactions with two model intestinal cell lines and show minimal cytotoxicity at concentrations below 5 mg mL−1.
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Generating Aptamers Interacting with Polymeric Surfaces for Biofunctionalization
Authors: Schulz Christian , Hecht Jochen , Krüger‐Genge Anne , Kratz Karl , Jung Friedrich , Lendlein Andreas 
Published: October 2016

Common strategies for biofunctionalization of surfaces comprise the immobilization of bioactive molecules used as cell‐binding ligands for cell recruitment. Besides covalent binding, multivalent noncovalent physical forces between substrate and ligand are an alternative way to equip surfaces with biomacromolecules. In this study, polymer binding ligands are screened by means of a DNA‐based in vitro selection process. As candidate biomaterials poly(ether imide) (PEI), polystyrene, and poly[ethylene‐co‐(vinyl acetate)] are selected, due to their different chemical structure, but similar macroscopic interface properties, allowing physical interaction with nucleotide bases by varying valences. Multivalent interacting aptamers are successfully enriched by SELEX method and an area‐wide surface functionalization is achieved, which can be used for further binding of bioactive molecules. In vitro selection against the polymers result in thymine‐dominated aptamer binding motifs. The preferential interaction with thymine is attributed to its chemical structure, connected with a decreased electrostatic repulsion of the π‐system and the hydrophobic character maximizing entropy. The aptamer binding stability correlates with available valences for interaction, resulting in a more stable functionalization of PEI.
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Objective Bayesian Comparison of Constrained Analysis of Variance Models
Authors: Consonni Guido , Paroli Roberta 
Published: October 2016

In the social sciences we are often interested in comparing models specified by parametric equality or inequality constraints. For instance, when examining three group means {μ1,μ2,μ3}\documentclass[12pt]{minimal}
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\begin{document}$$\{ \mu _1, \mu _2, \mu _3\}$$\end{document} through an analysis of variance (ANOVA), a model may specify that μ1<μ2<μ3\documentclass[12pt]{minimal}
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\begin{document}$$\mu _1<\mu _2<\mu _3$$\end{document}, while another one may state that {μ1=μ3}<μ2\documentclass[12pt]{minimal}
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\begin{document}$$\{ \mu _1=\mu _3\} <\mu _2$$\end{document}, and finally a third model may instead suggest that all means are unrestricted. This is a challenging problem, because it involves a combination of nonnested models, as well as nested models having the same dimension. We adopt an objective Bayesian approach, requiring no prior specification from the user, and derive the posterior probability of each model under consideration. Our method is based on the intrinsic prior methodology, suitably modified to accommodate equality and inequality constraints. Focussing on normal ANOVA models, a comparative assessment is carried out through simulation studies. We also present an application to real data collected in a psychological experiment.
PERMISSIVISM AND THE ARBITRARINESS OBJECTION
Authors: Mark simpson Robert 
Published: October 2016

ABSTRACTPermissivism says that for some propositions and bodies of evidence, there is more than one rationally permissible doxastic attitude that can be taken towards that proposition given the evidence. Some critics of this view argue that it condones, as rationally acceptable, sets of attitudes that manifest an untenable kind of arbitrariness. I begin by providing a new and more detailed explication of what this alleged arbitrariness consists in. I then explain why Miriam Schoenfield's prima facie promising attempt to answer the Arbitrariness Objection, by appealing to the role of epistemic standards in rational belief formation, fails to resolve the problem. Schoenfield's strategy is, however, a useful one, and I go on to explain how an alternative form of the standards-based approach to Permissivism – one that emphasizes the significance of the relationship between people's cognitive abilities and the epistemic standards that they employ – can respond to the arbitrariness objection.
Poor stimulus discriminability as a common neuropsychological deficit between ADHD and reading ability in young children: a moderated mediation model
Authors: Lúcio P. S. , Salum G. A. , Rohde L. A. , Swardfager W. , Gadelha A. , Vandekerckhove J. , Pan P. M. , Polanczyk G. V. , do Rosário M. C. , Jackowski A. P. , Mari J. J. , Cogo-Moreira H. 
Published: October 2016

BackgroundAttention deficit hyperactivity disorder (ADHD) is frequently associated with poorer reading ability; however, the specific neuropsychological domains linking this co-occurrence remain unclear. This study evaluates information-processing characteristics as possible neuropsychological links between ADHD symptoms and RA in a community-based sample of children and early adolescents with normal IQ (⩾70).MethodThe participants (n = 1857, aged 6–15 years, 47% female) were evaluated for reading ability (reading single words aloud) and information processing [stimulus discriminability in the two-choice reaction-time task estimated using diffusion models]. ADHD symptoms were ascertained through informant (parent) report using the Development and Well-Being Assessment (DAWBA). Verbal working memory (VWM; digit span backwards), visuospatial working memory (VSWM, Corsi Blocks backwards), sex, socioeconomic status, and IQ were included as covariates.ResultsIn a moderated mediation model, stimulus discriminability mediated the effect of ADHD on reading ability. This indirect effect was moderated by age such that a larger effect was seen among younger children.ConclusionThe findings support the hypothesis that ADHD and reading ability are linked among young children via a neuropsychological deficit related to stimulus discriminability. Early interventions targeting stimulus discriminability might improve symptoms of inattention/hyperactivity and reading ability.
Ontology-based executable design decision template representation and reuse
Authors: Ming Zhenjun , Yan Yan , Wang Guoxin , Panchal Jitesh H. , Goh Chung-Hyun , Allen Janet K. , Mistree Farrokh 
Published: October 2016

AbstractIn decision-based design, the principal role of a designer is to make decisions. Decision support is crucial to augment this role. In this paper, we present an ontology that provides decision support from both the “construct” and the “information” perspectives that address the gap that existing research focus on these two perspectives separately and cannot provide effective decision support. The decision support construct in the ontology is the compromise decision support problem (cDSP) that is used to make multiobjective design decisions. The information for decision making is archived as cDSP templates and represented using frame-based ontology for facilitating reuse, consistency maintaining, and rapid execution. In order to facilitate designers’ effective reuse of the populated cDSP templates ontology instances, we identified three types of modification that can be made when design consideration evolves. In our earlier work, part of the utilization (consistency checking) of the ontology has been demonstrated through a thin-walled pressure vessel redesign example. In this paper, we comprehensively present the ontology utilization including consistency checking, trade-off analysis, and design space visualization based on the pressure vessel example.