bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the readiness of the BRICS grouping for mutually beneficial financial integration
Authors: Bonga‐Bonga Lumengo 
Published: June 2017

AbstractThis paper assesses the extent of transmission of volatility shocks in the equity and foreign exchange markets among BRICS (Brazil, Russia, India, China and South Africa) countries to infer the degree of risk sharing and the possibility of a beneficial financial integration among its member countries. To this end, the paper makes use of the spillover index methodology suggested by Diebold and Yilmaz (). Nonetheless, the paper extends this methodology by incorporating ex ante volatility measures that account for long memory in equity and foreign exchange markets. The paper finds asymmetric influences among BRICS countries in relation to the cross transmission of risks. The finding of the paper implies the possibility of unequal benefit that could result from a possible capital market liberalization between the BRICS countries.
A dose‐escalation study of combretastatin A4‐phosphate in healthy dogs
Authors: Abma E. , Smets P. , Daminet S. , Cornelis I. , De Clercq K. , Ni Y. , Vlerick L. , de Rooster H. 
Published: June 2017

Combretastatin A4‐Phosphate (CA4P) is a vascular disrupting agent revealing promising results in cancer treatments for humans. The aim of this study was to investigate the safety and adverse events of CA4P in healthy dogs as a prerequisite to application of CA4P in dogs with cancer.Ten healthy dogs were included. The effects of escalating doses of CA4P on physical, haematological and biochemical parameters, systolic arterial blood pressure, electrocardiogram, echocardiographic variables and general wellbeing were characterised. Three different doses were tested: 50, 75 and 100 mg m−2.At all 3 CA4P doses, nausea, abdominal discomfort as well as diarrhoea were observed for several hours following administration. Likewise, a low‐grade neutropenia was observed in all dogs. Doses of 75 and 100 mg m−2 additionally induced vomiting and elevation of serum cardiac troponine I levels. At 100 mg m−2, low‐grade hypertension and high‐grade neurotoxicity were also observed.In healthy dogs, doses up to 75 mg m−2 seem to be well tolerated. The severity of the neurotoxicity observed at 100 mg m−2, although transient, does not invite to use this dose in canine oncology patients.
A dog as a generalist plant detection tool
Authors: Mclean I G , Sargisson R J 
Published: June 2017

SummaryWe tested the training of a dog as a generalist plant detector, to be used when plants are at low density or are difficult to find. Using a match‐to‐sample (MTS) protocol and a 10‐choice array, the dog found 11 plant species with 100% reliability from the first trial, and all 19 species tested with 100% reliability after three trials. The dog reliably found other parts of the same plant species when only one part was offered (e.g. flowers offered and leaves found). The methodology focussed on successful detection of an array of species, but false alarms (FAs) are also an issue when using any detection system. Most FAs given by the dog were of the plant used in the immediately preceding trial (proactive interference), which would not occur in an operational situation. Dogs have the potential to serve as generalist plant detectors, and training with the MTS protocol is a suitable and efficient method for producing such a dog.
Complete Genome Sequence of Edwardsiella ictaluri Isolate RUSVM-1 Recovered from Nile Tilapia (
Oreochromis niloticus
) in the Western Hemisphere
Authors: Reichley Stephen R. , Waldbieser Geoffrey C. , Soto Esteban , Lawrence Mark L. , Griffin Matt J. 
Published: June 2017

ABSTRACT

Edwardsiella ictaluri
is a Gram-negative bacillus that has recently been implicated in disease outbreaks in tilapia and zebrafish. We report here the complete and annotated genome sequence of an isolate from a Nile tilapia (
Oreochromis niloticus
), which contains a chromosome of 3,630,639 bp and two plasmids.
Complete Genome Sequence of Biocontroller Bacillus velezensis Strain JTYP2, Isolated from Leaves of
Echeveria laui
Authors: Wang Beibei , Liu Hu , Ma Hailin , Wang Chengqiang , Liu Kai , Li Yuhuan , Hou Qihui , Ge Ruofei , Zhang Tongrui , Liu Fangchun , Ma Jinjin , Wang Yun , Wang Haide , Xu Baochao , Yao Gan , Xu Wenfeng , Fan Lingchao , Ding Yanqin , Du Binghai 
Published: June 2017

ABSTRACT

Bacillus velezensis
JTYP2 was isolated from the leaves of
Echeveria laui
in Qingzhou, China, and may control some of the fungal pathogens of the plant. Here, we present the complete genome sequence of
B. velezensis
JTYP2. Several gene clusters related to its biosynthesis of antimicrobial compounds were predicted.
Genome Sequence of
Prosthecochloris
sp. Strain HL-130-GSB, from the Phylum
Chlorobi
Authors: Thiel Vera , Drautz-Moses Daniela I. , Purbojati Rikky W. , Schuster Stephan C. , Lindemann Stephen , Bryant Donald A. 
Published: June 2017

ABSTRACT

The genome of the green sulfur bacterium
Prosthecochloris
sp. strain HL-130-GSB, isolated from a cyanobacterial mat obtained from Hot Lake, a saline meromictic lake in Washington, USA, comprises 2,437,774 bp in a single contig. The genome is predicted to encode 2,565 proteins and contain 47 tRNA genes and 2 rRNA operons.
First Insights into the Genome Sequence of Clostridium oryzae DSM 28571, Isolated from the Soil of a Japanese Rice Field
Authors: Poehlein Anja , Gippert Anna Lena , Bierenbroodspot Maaike J. , Daniel Rolf 
Published: June 2017

ABSTRACT

Clostridium oryzae
was originally isolated from the soil of a Japanese rice field.
C. oryzae
represents a novel species within the genus
Clostridium
and is associated with anaerobic rice straw degradation. Here, we present the draft genome sequence of
C. oryzae
DSM 28571 (5.076 Mbp), containing 4,590 predicted protein-coding genes.
Complete Genome Sequence of the Campylobacter cuniculorum Type Strain LMG 24588
Authors: Miller William G. , Yee Emma , Revez Joana , Bono James L. , Rossi Mirko 
Published: June 2017

ABSTRACT

Campylobacter cuniculorum
is a thermotolerant species isolated from farmed rabbits (
Oryctolagus cuniculus
). Although
C. cuniculorum
is highly prevalent in rabbits farmed for human consumption, the pathogenicity of this organism in humans is still unknown. This study describes the whole-genome sequence of the
C. cuniculorum
type strain LMG 24588 (=CCUG 56289
T
).
Draft Genome Sequences of Six Enterococcus faecalis Strains Isolated from Malaysian Clinical and Environmental Origins
Authors: Daniel Diane Sunira , Gan Han Ming , Lee Sui Mae , Dykes Gary A. , Rahman Sadequr 
Published: June 2017

ABSTRACT

Enterococcus faecalis
is known to cause a variety of nosocomial infections, including urinary tract infections. Antibiotic resistance and virulence properties in this species are of public concern. The draft genome sequences of six
E. faecalis
strains isolated from clinical and environmental sources in Malaysia are presented here.
Complete Genome Sequence of a Legionella longbeachae Serogroup 1 Strain Isolated from a Patient with Legionnaires’ Disease
Authors: Slow Sandy , Anderson Trevor , Miller James , Singh Siddharth , Murdoch David , Biggs Patrick J. 
Published: June 2017

ABSTRACT

Legionella longbeachae
serogroup 1, predominantly found in soil and composted plant material, causes the majority of cases of Legionnaires’ disease (LD) in New Zealand. Here, we report the complete genome sequence of an
L. longbeachae
serogroup 1 (sg1) isolate derived from a patient hospitalized with LD in Christchurch, New Zealand.
Medicoeconomic analysis of lobectomy using thoracoscopy versus thoracotomy for lung cancer: a study protocol for a multicentre randomised controlled trial (Lungsco01)
Authors: Pagès Pierre-Benoit , Abou Hanna Halim , Bertaux Anne-Claire , Serge Aho Ludwig Serge , Magdaleinat Pierre , Baste Jean-Marc , Filaire Marc , de Latour Richard , Assouad Jalal , Tronc François , Jayle Christophe , Mouroux Jérome , Thomas Pascal-Alexandre , Falcoz Pierre-Emmanuel , Marty-Ané Charles-Henri , Bernard Alain 
Published: June 2017

IntroductionIn the last decade, video-assisted thoracoscopic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC) has had a major effect on thoracic surgery. Retrospective series have reported benefits of VATS when compared with open thoracotomy in terms of postoperative pain, postoperative complications and length of hospital stay. However, no large randomised control trial has been conducted to assess the reality of the potential benefits of VATS lobectomy or its medicoeconomic impact.Methods and analysisThe French National Institute of Health funded Lungsco01 to determine whether VATS for lobectomy is superior to open thoracotomy for the treatment of NSCLC in terms of economic cost to society. This trial will also include an analysis of postoperative outcomes, the length of hospital stay, the quality of life, long-term survival and locoregional recurrence. The study design is a two-arm parallel randomised controlled trial comparing VATS lobectomy with lobectomy using thoracotomy for the treatment of NSCLC. Patients will be eligible if they have proven or suspected lung cancer which could be treated by lobectomy. Patients will be randomised via an independent service. All patients will be monitored according to standard thoracic surgical practices. All patients will be evaluated at day 1, day 30, month 3, month 6, month 12 and then every year for 2 years thereafter. The recruitment target is 600 patients.Ethics and disseminationThe protocol has been approved by the French National Research Ethics Committee (CPP Est I: 09/06/2015) and the French Medicines Agency (09/06/2015). Results will be presented at national and international meetings and conferences and published in peer-reviewed journals.Trial registration numberNCT02502318.
Association of hypercapnia on admission with increased length of hospital stay and severity in patients admitted with community-acquired pneumonia: a prospective observational study from Pakistan
Authors: Iqbal Nousheen , Irfan Muhammad , Zubairi Ali Bin Sarwar , Awan Safia , Khan Javaid A 
Published: June 2017

ObjectiveTo determine whether the presence of hypercapnia on admission in adult patients admitted to a university-based hospital in Karachi, Pakistan with community-acquired pneumonia (CAP) correlates with an increased length of hospital stay and severity compared with no hypercapnia on admission.Study designA prospective observational study.SettingsTertiary care hospital in Karachi, Pakistan.MethodsPatients who met the inclusion criteria were enrolled in the study. The severity of pneumonia was assessed by CURB-65 and PSI scores. An arterial blood gas analysis was obtained within 24 hours of admission. Based on arterial PaCO2levels, patients were divided into three groups: hypocapnic (PaCO2<35 mm Hg), hypercapnic (PaCO2>45 mm Hg) and normocapnic (PaCO2<35–45 mm Hg).OutcomesThe primary outcome was the association of hypercapnia on admission with mean length of hospital stay. Secondary outcomes were the need for mechanical ventilation, ICU admission and in-hospital mortality.ResultsA total of 295 patients of mean age 60.20±17.0 years (157 (53.22%) men) were enrolled over a 1-year period. Hypocapnia was found in 181 (61.35%) and hypercapnia in 57 (19.32%) patients. Hypercapnic patients had a longer hospital stay (mean 9.27±7.57 days), increased requirement for non-invasive mechanical ventilation (NIMV) on admission (n=45 (78.94%)) and longer mean time to clinical stability (4.39±2.0 days) compared with the other groups. Overall mortality was 41 (13.89%), but there was no statistically significant difference in mortality (p=0.35) and ICU admission (p=0.37) between the three groups. On multivariable analysis, increased length of hospital stay was associated with NIMV use, ICU admission, hypercapnia and normocapnia.ConclusionHypercapnia on admission is associated with severity of CAP, longer time to clinical stability, increased length of hospital stay and need for NIMV. It should be considered as an important criterion to label the severity of the illness and also a determinant of patients who will require a higher level of hospital care. However, further validation is required.
Return to work of cancer patients after a multidisciplinary intervention including occupational counselling and physical exercise in cancer patients: a prospective study in the Netherlands
Authors: Leensen Monique C J , Groeneveld Iris F , Heide Iris van der , Rejda Tomas , van Veldhoven Peter L J , Berkel Sietske van , Snoek Aernout , Harten Wim van , Frings-Dresen Monique H W , de Boer Angela G E M 
Published: June 2017

ObjectivesTo support return to work (RTW) among cancer patients, a multidisciplinary rehabilitation programme was developed which combined occupational counselling with a supervised physical exercise programme during chemotherapy. The aim was to investigate RTW rates of cancer patients and to evaluate changes in work-related quality of life and physical outcomes.DesignLongitudinal prospective intervention study using a one-group design.SettingTwo hospitals in the Netherlands.ParticipantsOf the eligible patients, 56% participated; 93 patients with a primary diagnosis of cancer receiving chemotherapy and on sick leave were included. Patients completed questionnaires on RTW, the importance of work, work ability (WAI), RTW self-efficacy, fatigue (MFI), and quality of life (EORTC QLQ C-30) at baseline and 6, 12 and 18 months follow-up. Before and after the exercise programme 1-repetition maximum (1RM) muscle strength and cardiorespiratory fitness (VO2peak) were assessed.ResultsSix months after the start of a multidisciplinary rehabilitation programme that combined occupational counselling with a supervised physical exercise programme, 59% of the cancer patients returned to work, 86% at 12 months and 83% at 18 months. In addition, significant improvements (p<0.05) in the importance of work, work ability, RTW self-efficacy, and quality of life were observed, whereas fatigue levels were significantly reduced. After completing the exercise programme, 1RM muscle strength was significantly increased but there was no improvement in VO2peak level.ConclusionsRTW rates of cancer patients were high after completion of the multidisciplinary rehabilitation programme. A multidisciplinary rehabilitation programme which combines occupational counselling with a supervised physical exercise programme is likely to result in RTW, reduced fatigue and increased importance of work, work ability, and quality of life.
Herbal medicine (Hyeolbuchukeo-tang or Xuefu Zhuyu decoction) for treating primary dysmenorrhoea: protocol for a systematic review of randomised controlled trials
Authors: Jo Junyoung , Leem Jungtae , Lee Jin Moo , Park Kyoung Sun 
Published: June 2017

IntroductionPrimary dysmenorrhoea is menstrual pain without pelvic pathology and is the most common gynaecological condition in women. Xuefu Zhuyudecoction (XZD) or Hyeolbuchukeo-tang, a traditional herbal formula, has been used as a treatment for primary dysmenorrhoea. The purpose of this study is to assess the current published evidence regarding XZD as treatment for primary dysmenorrhoea.Materials and methodsThe following databases will be searched from their inception until April 2017: MEDLINE (via PubMed), Allied and Complementary Medicine Database (AMED), EMBASE, The Cochrane Library, six Korean medical databases (Korean Studies Information Service System, DBPia, Oriental Medicine Advanced Searching Integrated System, Research Information Service System, Korea Med and the Korean Traditional Knowledge Portal), three Chinese medical databases (China National Knowledge Infrastructure (CNKI), Wan Fang Database and Chinese Scientific Journals Database (VIP)) and one Japanese medical database (CiNii). Randomised clinical trials (RCTs) that will be included in this systematic review comprise those that used XZD or modified XZD. The control groups in the RCTs include no treatment, placebo, conventional medication or other treatments. Trials testing XZD as an adjunct to other treatments and studies where the control group received the same treatment as the intervention group will be also included. Data extraction and risk of bias assessments will be performed by two independent reviewers. The risk of bias will be assessed with the Cochrane risk of bias tool. All statistical analyses will be conducted using Review Manager software (RevMan V.5.3.0).Ethics and disseminationThis systematic review will be published in a peer-reviewed journal. The review will also be disseminated electronically and in print. The review will benefit patients and practitioners in the fields of traditional and conventional medicine.PROSPERO registration numberCRD42016050447.
Qualitative analysis of 6961 free-text comments from the first National Cancer Patient Experience Survey in Scotland
Authors: Cunningham Maggie , Wells Mary 
Published: June 2017

ObjectivesTo analyse free-text responses from the first Scottish Cancer Patient Experience Survey (SCPES) to understand patients’ experiences of care, identify valued aspects and areas for improvement.DesignInductive thematic analysis of seven free-text comment boxes covering all stages of the cancer experience, from a national cohort survey.Setting and participantsAdult cancer patients diagnosed across all Health Boards in Scotland between July 2013 and March 2014, and who had an inpatient stay or hospital visit between January and September 2014. 2663 respondents (of n=4835 survey respondents) provided 6961 free-text comments.Main outcome measuresPositive and negative themes of patients’ experiences. Differences in the proportion of positive to negative comments by demographics.MethodsData were analysed as follows: (1) comments were initially categorised at a high level (eg, positive, negative, miscellaneous, etc); (2) inductive codes were derived and applied to all relevant comments; (3) codes sharing similar meaning were amalgamated into subthemes, and code frequencies were measured; (4) subthemes were mapped into overarching themes; (5) difference in the proportion of positive to negative comments by demographics were analysed using χ2tests.ResultsParticipants made more positive than negative comments (1:0.78). Analysis highlighted the importance to patients ofFeeling that Individual Needs Are MetandFeeling Confident Within the System. Comments also provided insight into howProcessesandStructureswithin the system of care can negatively impact on patients’ experience. Particular issues were identified with care experiences in the lead-up to diagnosis.ConclusionsThis analysis provides a detailed understanding of patients’ cancer care experiences, therefore indicating what aspects matter in those experiences. Although the majority of comments were positive, there were a significant number of negative comments, especially about the lead-up to diagnosis. Comments suggest patients would value greater integration of care from services involved in their treatment for cancer.
Community gardening, community farming and other local community-based gardening interventions to prevent overweight and obesity in high-income and middle-income countries: protocol for a systematic review
Authors: Heise Thomas L , Romppel Matthias , Molnar Sandra , Buchberger Barbara , Berg Agnes van den , Gartlehner Gerald , Lhachimi Stefan K 
Published: June 2017

IntroductionThe worldwide prevalence of overweight/obesity has continued to rise over the last decades. To reverse this trend, public health authorities are exploring cost-effective interventions, especially in high-income and middle-income countries. Community gardening offers a unique opportunity for individuals to enhance physical activity levels and improve their diet. However, synthesised evidence on the short-term or long-term effectiveness and on the costs of community gardening interventions to prevent overweight/obesity remains limited. Therefore, this review will investigate: (1) the effectiveness of voluntary participation in community gardening compared with no or a control intervention on overweight/obesity and associated health outcomes, (2) effects on different subgroups of populations and (3) the costs of community gardening interventions.Methods and analysisWe will conduct a systematic review, limited to evaluations of community gardening interventions with controlled quantitative and interrupted time series designs. To identify relevant articles, we will systematically search 12 academic and 5 grey literature databases, as well as 2 trial registers and 6 websites. Articles will then be assessed for eligibility based on a predefined set of criteria. At least two independent reviewers will assess each article for relevance, before evaluating the methodological quality and potential bias of the studies. Data relevant to the objectives of this review will be extracted and cross-validated. Any disagreements will be mediated by a third reviewer. If feasible, meta-analyses of primary outcomes (overweight/obesity, physical activity, food intake, energy intake) will be conducted. We will use the Grading of Recommendations Assessment, Development and Evaluation method to assess the overall quality of evidence.Ethics and disseminationFor this review, no ethical approval is required as we will only extract and analyse secondary data. We aim to submit the final review manuscript to an open access journal for publication and disseminate results via conferences and social media.Trial registration numberInternational Prospective Register of Systematic Reviews (PROSPERO)(CRD42017043696).
Relationships between socioeconomic position and objectively measured sedentary behaviour in older adults in three prospective cohorts
Authors: Shaw Richard John , Čukić Iva , Deary Ian J , Gale Catharine R , Chastin Sebastien FM , Dall Philippa M , Skelton Dawn A , Der Geoff 
Published: June 2017

ObjectivesTo investigate whether sedentary behaviour in older adults is associated with a systematic and comprehensive range of socioeconomic position (SEP) measures across the life course. SEP measures included prospective measures of social class, income, educational qualifications and parental social class and contemporaneous measures of area deprivation.SettingGlasgow and the surrounding (West of Scotland) combined with Edinburgh and the surrounding area (the Lothians).ParticipantsCommunity-dwelling adults aged around 79, 83, and 64 years from, respectively, the Lothian Birth Cohort 1936 (LBC1936) (n=271) and the 1930s (n=119) and 1950s (n=310) cohorts of the West of Scotland Twenty-07 study.Primary outcome measureSedentary behaviour was measured objectively using an activPAL activity monitor worn continuously for 7 days and used to calculate percentage of waking time spent sedentary.ResultsAmong retired participants, for most cohort and SEP combinations, greater social disadvantage was associated with increased sedentary time. For example, in the Twenty-07 1930s cohort, those most deprived on the Carstairs measure spent 6.5% (95% CI 0.3 to 12.7) more of their waking time sedentary than the least deprived. However, for employed people, the relationship between SEP and sedentary behaviour was much weaker. For example, in terms of social class differences, among the retired, the most disadvantaged spent 5.7% more waking time sedentary (95% CI 2.6% to 87%), whereas among the employed, there was effectively no difference (−0.5%; 95% CI −9.0 to 8.0).ConclusionsDiverse SEP measures were associated with increased sedentary behaviour among retired people. There was little evidence for a relationship between SEP measures and sedentary behaviour among employed older adults. Prior to retirement, the constraints of the workplace may be masking effects that are only apparent at weekends.