bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma
Authors: Drew Allison E. , Moradei Oscar , Jacques Suzanne L. , Rioux Nathalie , Boriack-Sjodin Ann P. , Allain Christina , Scott Margaret Porter , Jin Lei , Raimondi Alejandra , Handler Jessica L. , Ott Heidi M. , Kruger Ryan G. , McCabe Michael T. , Sneeringer Christopher , Riera Thomas , Shapiro Gideon , Waters Nigel J. , Mitchell Lorna H. , Duncan Kenneth W. , Moyer Mikel P. , Copeland Robert A. , Smith Jesse , Chesworth Richard , Ribich Scott A. 
Published: December 2017

AbstractCARM1 is an arginine methyltransferase with diverse histone and non-histone substrates implicated in the regulation of cellular processes including transcriptional co-activation and RNA processing. CARM1 overexpression has been reported in multiple cancer types and has been shown to modulate oncogenic pathways in in vitro studies. Detailed understanding of the mechanism of action of CARM1 in oncogenesis has been limited by a lack of selective tool compounds, particularly for in vivo studies. We describe the identification and characterization of, to our knowledge, the first potent and selective inhibitor of CARM1 that exhibits anti-proliferative effects both in vitro and in vivo and, to our knowledge, the first demonstration of a role for CARM1 in multiple myeloma (MM). EZM2302 (GSK3359088) is an inhibitor of CARM1 enzymatic activity in biochemical assays (IC50 = 6 nM) with broad selectivity against other histone methyltransferases. Treatment of MM cell lines with EZM2302 leads to inhibition of PABP1 and SMB methylation and cell stasis with IC50 values in the nanomolar range. Oral dosing of EZM2302 demonstrates dose-dependent in vivo CARM1 inhibition and anti-tumor activity in an MM xenograft model. EZM2302 is a validated chemical probe suitable for further understanding the biological role CARM1 plays in cancer and other diseases.
New tests, new tools: mobile and connected technologies in advancing psychiatric diagnosis
Authors: Roberts Laura Weiss , Chan Steven , Torous John 
Published: December 2017

AbstractMental health is an area of growing interest in the digital health space. Mobile and connected technologies offer new tools that can potentially aid in both the diagnostic and interventional aspects of psychiatric care. To understand the potential of these digital tools in psychiatry, this paper offers an overview of the development, current research, clinical use cases, and next steps necessary to realize the potential of digital health in mental health. Focusing on smartphones’ and wearable sensors’ ability to advance clinical data collection via multiple domains: self-report, behavioral, and physiological, we explore opportunities and challenges in translating these technologies into clinical care tools that can advance how we understand and approach mental illness.
Miniaturised ISM band HMSIW band‐pass filter loaded with wide U slot
Authors: Sandhya Ramalingam , Habiba Hyder Ali Umma 
Published: December 2017

In this study, two half‐mode substrate integrated waveguide (HMSIW) filters are proposed by introducing wide U slot in the conventional SIW (substrate integrated waveguide) structure. In the first case, lower ISM (industrial, scientific and medical radio) band HMSIW filter is designed by extending the centre stub, thereby controlling the resonant frequency and bandwidth. In the second case, higher ISM band HMSIW filter is designed by shorting the extended stub using via. These filters are having a compact core size of 26 mm × 11 mm and work at 2.4 and, 5.8 GHz with a fractional bandwidth of 4.0 and 2.6%, respectively. The filter is fabricated with a single layer standard printed circuit board process. The measured results are good and in agreement with simulated results. The band‐pass filter structure has the advantage of low insertion loss, good return loss, sharp side band rejection and compact size.
Palliative Embolization for Refractory Bleeding
Authors: Niekamp Andrew , Sheth Rahul , Kuban Joshua , Avritscher Rony , Ganguli Suvranu 
Published: December 2017

AbstractBleeding is a common and often challenging complication of malignancy. Etiologies of hemorrhage in this patient population vary, and bleeding may present as an acute, life-threatening emergency or a chronic, low-volume blood loss. For patients with advanced malignancies, interventions to manage bleeding must be balanced by the patient's life expectancy and quality of life. As such, minimally invasive procedures such as transarterial embolization are useful therapeutic options in appropriately selected patients. There is a rich history of palliative transarterial embolization for refractory bleeding in cancer patients. This technique was first applied in the 1970s and has since become an established treatment tool for malignancy-related bleeding throughout the body. While the preponderance of published data comprised case reports and small retrospective studies, the use of embolization continues to expand as experience grows and techniques are refined. In this review, we summarize the literature and provide our perspective on embolization for refractory bleeding in cancer patients.
Risiken umschiffen
Authors: Ehrengruber Maximilian , Wurm Claudius 
Published: December 2017

Zusammenfassung
Risikokompass „Heute wurden Instrumente in einem falschen Container verpackt und keinem ist es aufgefallen.“ Kommen Ihnen solche oder
ähnliche Aussagen bekannt vor? Im OP und in der Medizinprodukteaufbereitung lauern zahlreiche Risiken, die es zu verhindern gilt. Unsere
Autoren haben deshalb eine Methode entwickelt, mit der das Risikomanagement für alle Mitarbeiter verständlich und leicht anwendbar ist: den
Risikokompass.
Sichere Begleitung für Siebe
Authors: Stark Uwe 
Published: December 2017

Zusammenfassung
Leihsiebe In der täglichen OP-Praxis, insbesondere in der Orthopädie und Unfallchirurgie, sind sie nicht mehr wegzudenken: Leihsiebe.
Damit alle Beteiligten den Überblick behalten, hat unser Autor einen internen Begleitschein für Leihsiebe und -implantate entwickelt, der
die Dokumentation erleichtert und ein strukturiertes und transparentes Vorgehen ermöglicht.
Standardisierte Medizin – der Weg in die Zukunft
Authors: Solcher Bertram 
Published: December 2017

Zusammenfassung
Digitalisierung Medizin 4.0 oder Robotermedizin – wie immer man die technisch unterstützten Arbeitsprozesse nennt, sie sorgen für
Skepsis. Dabei birgt der Trend großes Potenzial für Kliniken, außerdem setzt Digitalisierung dort an, wo es niemandem weh tut.
Vom Bildarchiv zum Informationspool
Authors: Kucera Martin 
Published: December 2017

Zusammenfassung
PACS-Systeme Die zunehmende Digitalisierung im Krankenhaus produziert immer mehr Bilder, Videos und elektronische Dokumente. Um dieser
Datenflut Herr zu werden, braucht es eine IT-Strategie. Die Anbieter setzten bei ihren PACS-Systemen auf größtmögliche Flexibilität.
Schuleingangsuntersuchung bei Seiteneinsteigenden – was kann, was soll sie leisten? Ein Diskussionsbeitrag auf Grundlage der Daten aus dem Gesundheitsamt Frankfurt am Main 2006–2016
Authors: Karathana Maria , Krackhardt Bernhard , Schade Manuela , Heudorf Ursel 
Published: December 2017

Zusammenfassung
Fragestellung Die Untersuchung der Schulanfänger ist eine der wesentlichen Aufgaben der Kinder- und Jugendärztlichen Dienste der Gesundheitsämter. Während in allen Bundesländern die Untersuchung aller Erstklässler vor Schuleintritt gesetzlich klar festgeschrieben ist, ist die Situation für Seiteneinsteigende, d.h. Kinder im schulpflichtigen Alter, die aus dem Ausland in eine Gemeinde zuziehen und dort eingeschult werden, in den meisten Schulgesetzen nicht eindeutig geregelt. In dem Beitrag werden die Erfahrungen aus den Seiteneinsteigenden-Untersuchungen in Frankfurt am Main geschildert.
Methode Alle aus dem Ausland nach Frankfurt zugezogenen Kinder im schulpflichtigen Alter werden im Gesundheitsamt untersucht. Diese Untersuchung umfasst eine mithilfe von Dolmetschern durchgeführte standardisierte fragebogengestützte Anamnese inkl. Durchsicht des ggf. vorhandenen Impfbuchs (Anamnesebögen sind in verschiedenen Sprachen vorhanden), einen Seh- und Hörtest sowie eine körperliche Untersuchung. Kinder über 15 Jahren, die aus Hochprävalenzländern für eine Tuberkulose kommen, wurden geröntgt (Röntgen-Thorax).
Ergebnisse Von 2006 bis Ende 2016 wurden insgesamt 8245 Kinder- und Jugendliche untersucht. Auffälligkeiten im Hörscreening wiesen 4% der Untersuchten auf, im Sehscreening 22% – mit steigender Tendenz in den letzten Jahren. Bei zwei Drittel der Kinder blieb der Impfstatus unbekannt, ein Viertel der Kinder war ausreichend gegen Tetanus, Diphtherie, Polio und Pertussis geimpft, 19,5% waren gegen Masern immun (geimpft oder durchgemachte Erkrankung). Bei der körperlichen Untersuchung dominierten Erkrankungen der Atemwege, des Herzens und des Kreislaufs mit insgesamt 4% vor den Muskel-Skeletterkrankungen mit 3%. Läusebefall wurde bei 1,7% der Kinder festgestellt. Bei 0,7% der 2171 geröntgten Kinder wurde ein auffälliger Lungenbefund ermittelt, in keinem einzigen Fall eine Tuberkulose.
Schlussfolgerung Fokus der Seiteneinsteigenden-Untersuchung ist ein schulbezogener Gesundheitsstatus. Auf Grundlage der Erfahrungen aus Frankfurt am Main ist festzustellen, dass die Untersuchung der aus anderen Ländern zugezogenen Seiteneinsteigenden sinnvoll erscheint, insbesondere das Seh- und Hörscreening, die körperliche Untersuchung und die Überprüfung des Impfstatus, ggf. mit Schließung der Impflücken. Demgegenüber erscheint eine ausführliche Entwicklungsdiagnostik bei den unmittelbar schulpflichtigen Kindern und damit bei fehlenden Fördermöglichkeiten vor Schulbeginn nicht vordringlich.
Neuraltherapie in Gynäkologie und Geburtshilfe
Authors: Bernert Klaus-Dieter 
Published: December 2017

ZusammenfassungDie Neuraltherapie stellt ein Bindeglied zwischen Schul- und Komplementärmedizin dar. Die Behandlung mit Lokalanästhetika zielt darauf, sog.
Störfelder zu beseitigen und die körpereigene Regulationsfähigkeit wiederherzustellen.Am Beispiel von Beschwerden in Schwangerschaft, Wochenbett und Gynäkologie werden bewährte Injektionstechniken und deren mögliche Erfolge
anhand von Fällen aus der Praxis des Autors vorgestellt.
Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action
Authors: Robinson James I. , Baxter Euan W. , Owen Robin L. , Thomsen Maren , Tomlinson Darren C. , Waterhouse Mark P. , Win Stephanie J. , Nettleship Joanne E. , Tiede Christian , Foster Richard J. , Owens Raymond J. , Fishwick Colin W. G. , Harris Sarah A. , Goldman Adrian , McPherson Michael J. , Morgan Ann W. 
Published: December 2017

Significance
Autoimmune disease pathogenesis is driven by inflammation, induced partly by IgG autoantibody-containing immune complexes binding to Fc gamma receptors (FcγRs). These receptors are valid therapeutic targets in the treatment of autoimmunity. FcγRIIIa is one of a family of highly homologous receptors for IgG antibodies; previous attempts at therapeutic blockade have resulted in off-target effects involving cells that express the almost identical protein FcγRIIIb. Here we report the identification of functionally specific protein-based inhibitors (Affimer proteins) of FcγRIIIa and the structural/functional basis of their selectivity. As molecular research tools FcγRIIIa-specific Affimer proteins provide the ability to block IgG interaction with a single receptor. Our findings suggest that highly selective protein-based blocking agents that may have therapeutic applications can be readily produced.
Developing together with indigenous knowledge - mini review.
Authors: Sillitoe P. 
Published: December 2017

Abstract
Sustainable development requires integrated cooperation between various disciplines. But interdisciplinary research has proved a challenge. The indigenous knowledge (IK) in development approach arguably offers a promising context in which to further necessary interdisciplinary interaction in view of the holistic all-encompassing character of the know-how, experience and practices of local communities. We regularly hear calls for interdisciplinary, notably in development. It is widely agreed that a broad systems perspective is necessary to understand and address the complex problems of poverty, as evident in the natural resources field with the sustainable livelihoods approach. The current trend away from sector focused work - crop improvement, irrigation construction, livestock management, pest control - demands interdisciplinary, which requires cooperation between specialists with diverse backgrounds in both the natural and social sciences. Regardless of the exhortations, not in themselves new, achieving interdisciplinary co-operation has proved a challenge.
The unity of moral attitudes: recipe semantics and credal exaptation
Authors: Shiller Derek 
Published: December 2017

AbstractThis paper offers a noncognitivist characterization of moral attitudes, according to which moral attitudes count as such because of their inclusion of moral concepts. Moral concepts are distinguished by their contribution to the functional roles of some of the attitudes in which they can occur. They have no particular functional role in other attitudes, and should instead be viewed as evolutionary spandrels. In order to make the counter-intuitive implications of the view more palatable, the paper ends with an account of the evolution of normative judgments as exaptations of the cognitive structures that underlie beliefs.
Solving the problem of creeping minimalism
Authors: Simpson Matthew 
Published: December 2017

AbstractIn this paper I discuss the so-called problem of creeping minimalism, the problem of distinguishing metaethical expressivism from its rivals once expressivists start accepting minimalist theories about truth, representation, belief, and similar concepts. I argue that Dreier's ‘explanation’ explanation is almost correct, but by critically examining it we not only get a better solution, but also draw out some interesting results about expressivism and non-representationalist theories of meaning more generally.
Snake fangs: 3D morphological and mechanical analysis by microCT, simulation, and physical compression testing
Authors: du Plessis Anton , Broeckhoven Chris , le Roux Stephan G 
Published: December 2017

Abstract
This Data Note provides data from an experimental campaign to analyse the detailed internal and external morphology and mechanical properties of venomous snake fangs. The aim of the experimental campaign was to investigate the evolutionary development of 3 fang phenotypes and investigate their mechanical behaviour. The study involved the use of load simulations to compare maximum Von Mises stress values when a load is applied to the tip of the fang. The conclusions of this study have been published elsewhere, but in this data note we extend the analysis, providing morphological comparisons including details such as curvature comparisons, thickness, etc. Physical compression results of individual fangs, though reported in the original paper, were also extended here by calculating the effective elastic modulus of the entire snake fang structure including internal cavities for the first time. This elastic modulus of the entire fang is significantly lower than the locally measured values previously reported from indentation experiments, highlighting the possibility that the elastic modulus is higher on the surface than in the rest of the material. The micro–computed tomography (microCT) data are presented both in image stacks and in the form of STL files, which simplifies the handling of the data and allows its re-use for future morphological studies. These fangs might also serve as bio-inspiration for future hypodermic needles.
Evaluation of Retinal Changes in Progressive Supranuclear Palsy and Parkinson Disease
Authors: Gulmez Sevim Duygu , Unlu Metin , Gultekin Murat , Karaca Cagatay , Mirza Meral , Mirza Galip Ertugrul 
Published: December 2017

Background:
Differentiating Parkinson disease (PD) from progressive supranuclear palsy (PSP) can be challenging early in the clinical course. The aim of our study was to see if specific retinal changes could serve as a distinguishing feature.

Methods:
We used spectral domain optical coherence tomography (SD-OCT) with automatic segmentation to measure peripapillary nerve fiber layer thickness and the thickness and volume of retinal layers at the macula.

Results:
Thicknesses of superior peripapillary retinal nerve fiber layer (pRNFL), macular ganglion cell layer, inner plexiform layer, inner nuclear layer, and macular volume were more affected in PSP compared with PD (P < 0.05). Thicker inferotemporal pRNFL and lower macular volume were detected in levodopa users compared with nonusers in patients with PD.

Conclusions:
PD and PSP are associated with distinct changes in retinal morphology, which can be assessed with SD-OCT.
White matter correlates of hemi-face dominance in happy and sad expression
Authors: Ioannucci Stefano , George Nathalie , Friedrich Patrick , Cerliani Leonardo , de Schotten Michel Thiebaut 
Published: December 2017

AbstractThe neural underpinnings of human emotional expression are thought to be unevenly distributed among the two brain hemispheres. However, little is known on the anatomy supporting this claim, particularly in the cerebral white matter. Here, we explored the relationship between hemi-face dominance in emotional expression and cerebral white matter asymmetries in 33 healthy participants. Measures of emotional expression were derived from pictures of the participant’s faces in a ‘happy smiling’ and a ‘sad frowning’ conditions. Chimeric faces were constructed by mirroring right and left hemi-faces, as done in previous studies, resulting in a left mirrored and right mirrored chimeric face per picture. To gain measures of hemi-face dominance per participant, a jury of 20 additional participants rated which chimeric face shows higher intensity of emotional expressivity, by marking a 155mm line between the two versions. Measures of the asymmetry of the uncinate, the cingulum and the three branches of superior longitudinal fasciculi were derived from diffusion weighted imaging tractography dissections. Group effect analyses indicated that the degree of asymmetry in emotional expression was not as prominent as reported in the literature and showed a large inter-individual variability. The degree of asymmetry in emotional expression was, however, significantly associated with the asymmetries in connective properties of the fronto-temporal and fronto-parietal tracts, specifically the uncinate fasciculus and the first branch of the superior longitudinal fasciculus. Therefore, this result raises novel hypotheses on the relationship of specific white matter tracts and emotional expression, especially their role in mood disorders.Ethical statementNone of the authors have a conflict of interestData collection from human participants was approved by the Comité de Protection des Personnes “CPP Ile de France V”All participants provided written informed consentFunding from ERC (grant agreement No. 818521) and “Agence Nationale de la Recherche” [grants numbers ANR-13-JSV4-0001-01 an ANR-10-IAIHU-06]
FGFs are orchestra conductors of Shh-dependent oligodendroglial fate specification in the ventral spinal cord
Authors: Farreny Marie-Amélie , Agius Eric , Bel-Vialar Sophie , Escalas Nathalie , Khouri-Farah Nagham , Soukkarieh Chadi , Pituello Fabienne , Cochard Philippe , Soula Cathy 
Published: December 2017

AbstractMost oligodendrocytes of the spinal cord originate from ventral progenitor cells of the pMN domain, characterized by expression of the transcription factor Olig2. A minority of oligodendrocytes is also recognized to emerge from dorsal progenitors during fetal development. The prevailing view is that generation of ventral oligodendrocytes depends on Sonic hedgehog (Shh) while dorsal oligodendrocytes develop under the influence of Fibroblast Growth Factors (FGFs). Using the well-established model of the chicken embryo, we evidence that ventral spinal progenitor cells activate FGF signaling at the onset of oligodendrocyte precursor cell (OPC) generation, as do they dorsal counterpart. Inhibition of FGF receptors at that time appears sufficient to prevent generation of ventral OPCs, highlighting that, in addition to Shh, FGF signaling is required also for generation of ventral OPCs. We further reveal an unsuspected interplay between Shh and FGF signaling by showing that FGFs serve dual essential functions in ventral OPC specification. FGFs are responsible for timely induction of a secondary Shh signaling center, the lateral floor plate, a crucial step to create the burst of Shh required for OPC specification. At the same time, FGFs prevent down-regulation of Olig2 in pMN progenitor cells as these cells receive higher threshold of the Shh signal. Finally, we bring arguments favoring a key role of newly differentiated neurons acting as providers of the FGF signal required to trigger OPC generation in the ventral spinal cord.
CLAN: the CrossLinked reads ANalyais tool
Authors: Zhong Cuncong , Zhang Shaojie 
Published: December 2017

AbstractThe crosslinked RNA sequencing technology ligates interacting RNA strands followed by next-generation sequencing. Mapping of the resulting duplex reads allows for functional inference of the corresponding intramolecular/intermolecular RNA-RNA interactions. However, duplex read mapping remains computationally challenging, and the existing best-performing software fails to map a significant portion of the duplex reads. To address this challenge, we develop a novel algorithm for duplex read mapping, called CrossLinked reads ANalysis tool (CLAN). CLAN demonstrates drastically improved sensitivity and high alignment accuracy when applied to real crosslinked RNA sequencing data. CLAN is implemented in GNU C++, and is freely available from http://sourceforge.net/projects/clan-mapping.
A cortical immune network map identifies a subset of human microglia involved in Tau pathology
Authors: Patrick Ellis , Olah Marta , Taga Mariko , Klein Hans-Ulrich , Xu Jishu , White Charles C , Felsky Daniel , Gaiteri Chris , Chibnik Lori B , Mostafavi Sara , Schneider Julie A , Bennett David A , Bradshaw Elizabeth M , De Jager Philip L 
Published: December 2017

AbstractMicroglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer's disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five gene modules of co-expressed genes related to microglia and assess their role in the neuropathologic features of AD in 541 subjects from two cohort studies of brain aging. Two of these transcriptional programs – modules 113 and 114 – relate to the accumulation of β-amyloid, while module 5 relates to tau pathology. These modules are also detectable in the human brain's epigenome, where we replicate these associations. In terms of tau, we propose that module 5, a marker of activated microglia, may lead to tau accumulation and subsequent cognitive decline. We validate our model further by showing that VASP, a representative module 5 gene, encodes a protein that is upregulated in activated microglia in AD.