bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fracture Resistance of Premolars Restored Either with Short Fiber or Polyethylene Woven Fiber‐Reinforced Composite
Authors: Gürel Mügem Asli , Helvacioğlu Kivanç Bağdagül , Ekıcı Adil , Alaçam Tayfun 
Published: September 2016

AbstractObjectiveTo compare the fracture resistance of endodontically treated maxillary premolars with one remaining cavity wall restored either with short fiber‐reinforced composite or polyethylene woven fiber‐reinforced composite.Materials and MethodsForty‐eight maxillary premolars were endodontically treated and randomly assigned to four groups (n = 12). Palatal cusp was removed, buccal wall was remained. In groups 1 to 3, standardized cavities were prepared in the palatal canal entrances. In group 1, short fiber‐reinforced composite was used for restoration both of deep cavity and coronal part. In group 2, short fiber‐reinforced composite was placed inside the deep cavity and core part of the restoration. Coronal restoration was restored by using conventional filler composite. In group 3, both deep cavities and coronal parts were built up by using conventional filler composite. In group 4, post space was prepared in the palatal canal. Polyethylene woven fiber‐reinforced composite post then was placed into post space and the coronal part was restored by using conventional filler composite. Specimens were placed into a universal testing machine. The fracture loads were recorded and analyzed statistically using one‐way ANOVA (α = 0.05). Fracture patterns were analyzed by using Chi‐square test (α = 0.05).ResultsNo statistically significant difference was found in fracture strength (p > 0.05). Group 1 exhibited the highest and group 4 exhibited the lowest incidence of restorable fracture (p < 0.05).ConclusionsThe restoration of severely weakened premolar teeth with the use of short fiber‐reinforced composite might have advantages over conventional filler composite or polyethylene woven fiber‐reinforced composite techniques.Clinical SignificanceThe results of this in vitro study will be helpful to understand reinforced composite materials for restoring endodontically treated maxillary premolars. (J Esthet Restor Dent 28:412–418, 2016)
Kinesin‐14 is Important for Chromosome Segregation During Mitosis and Meiosis in the Ciliate Tetrahymena thermophila
Authors: Kushida Yasuharu , Takaine Masak , Nakano Kentaro , Sugai Toshiro , Vasudevan Krishna Kumar , Guha Mayukh , Jiang Yu‐Yang , Gaertig Jacek , Numata Osamu 
Published: September 2016

AbstractCiliates such as Tetrahymena thermophila have two distinct nuclei within one cell: the micronucleus that undergoes mitosis and meiosis and the macronucleus that undergoes amitosis, a type of nuclear division that does not involve a bipolar spindle, but still relies on intranuclear microtubules. Ciliates provide an opportunity for the discovery of factors that specifically contribute to chromosome segregation based on a bipolar spindle, by identification of factors that affect the micronuclear but not the macronuclear division. Kinesin‐14 is a conserved minus‐end directed microtubule motor that cross‐links microtubules and contributes to the bipolar spindle sizing and organization. Here, we use homologous DNA recombination to knock out genes that encode kinesin‐14 orthologues (KIN141, KIN142) in Tetrahymena. A loss of KIN141 led to severe defects in the chromosome segregation during both mitosis and meiosis but did not affect amitosis. A loss of KIN141 altered the shape of the meiotic spindle in a way consistent with the KIN141's contribution to the organization of the spindle poles. EGFP‐tagged KIN141 preferentially accumulated at the spindle poles during the meiotic prophase and metaphase I. Thus, in ciliates, kinesin‐14 is important for nuclear divisions that involve a bipolar spindle.
Characterization of circular RNAs landscape in multiple system atrophy brain
Authors: Chen Bei Jun , Mills James D. , Takenaka Konii , Bliim Nicola , Halliday Glenda M. , Janitz Michael 
Published: September 2016

AbstractCircular RNAs (circRNAs) have been recently identified as a naturally occurring family of widespread and diverse endogenous non‐coding RNAs that may regulate gene expression in mammals. They are unusually stable RNA molecules with cell type‐ or developmental stage‐specific expression patterns. However, the role of circRNAs in pathology of complex disease is entirely unknown. Here, we report the specific circular transcriptome in the multiple system atrophy (MSA) brain as determined by RNA sequencing. Five circRNAs, namely IQCK, MAP4K3, EFCAB11, DTNA, and MCTP1, were identified and validated as specifically over‐expressed in MSA frontal cortex. The expression levels of linear transcripts were not significantly altered and thus did not follow the pattern of their circular counterparts. Further analysis of expression of five MSA‐specific circRNAs revealed their over‐expression in the white matter of the MSA cortical tissue. Together, this is the first report describing perturbation of circular transcriptome in α‐synucleinopathies.
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Platelet‐rich plasma and hyaluronic acid – an efficient biostimulation method for face rejuvenation
Authors: Ulusal Betul Gozel 
Published: September 2016

SummaryBackgroundCosmetic applications of platelet‐rich plasma (PRP) are new, and reports are scarce and dispersed in the literature. There are a variety of commercially available kits and injection techniques, and the number and intervals of injections vary. New investigations should focus on developing a standardized procedure for PRP preparation and application methods to augment its efficacy and potency.ObjectivesIn this report, we aim to provide data and commentary to assist and add to current guidelines.MethodsA series of 94 female patients with varying degrees of facial aging signs were treated with PRP and hyaluronic acid (HA). Mean age was 53.0 ± 5.6. The mean injection number was 3.6 ± 2.0. Platelet‐poor and platelet‐ rich plasma parts were mixed with 0.5 cc %3.5 hyaluronic acid and 0.5 cc procaine and injected with a 30G, 13‐mm needle into deep dermis and hypodermis. Patients were asked to rate their personal satisfaction with their skin texture, pigmentation, and sagging. In addition, the overall results were rated by three independent physicians and the patients themselves. The outcomes were peer‐reviewed, and correlations between the degree of the aesthetic scores and the number of injections were explored.ResultsThere was a statistically significant difference in general appearance, skin firmness‐sagging and skin texture according to the patients’ before and after applications of PRP. A statistically significant correlation was found between the number of injections and overall satisfaction.ConclusionsCompared to the baseline, the PRP and HA injections provided clinically visible and statistically significant improvement on facial skin. The improvements were more remarkable as the injection numbers increased.
Hair removal‐related injuries in the United States, 1991–2014
Authors: Swain Thomas A , Tully Albert Scott , Redford Travis , McGwin Gerald 
Published: September 2016

SummaryBackgroundHair removal practices have changed in frequency and location on the body. Previous research on hair removal injuries has focused on a specific body region, age, or gender.ObjectiveThis study sought to take a broader perspective of hair removal‐associated injuries in the United States which sought treatment at emergency departments.MethodsData from the National Electronic Injury Surveillance System (NEISS) from 1991 to 2014 were used to identify hair removal‐related injuries. Incidence rates were determined for the overall population and stratified by gender and age category using US Census Bureau population estimates.ResultsFrom 1991 to 2014, there were an estimated 292 053 hair removal‐associated injuries in the United States. The overall incidence rate was highest in 2013 (9/100 000). Those aged 65+ had the highest incidence from 1991 to 2010 with those aged 19–34 having the highest rate starting in 2011. When stratified by body region injured, males had highest injury rates to the face and females had highest rates to the lower limbs. Starting in 2010, those aged 19–34 had higher incidence particularly for pubic and trunk regions.ConclusionThe incidence of hair removal‐associated injuries seen by emergency departments increased nearly ninefold between 1991 and 2013. Due to the increased incidence among 19‐ to 34‐year‐olds, caution should be taken particularly for this age group when undergoing depilatory practices. Overall, individuals should practice safe and acceptable usage of hair removal products to reduce the risk of injury.
Potential health hazards of eating red meat
Authors: Wolk A. 
Published: September 2016

AbstractRed meat (beef, veal, pork, lamb and mutton) consumption contributes several important nutrients to the diet, for example essential amino acids, vitamins (including B12) and minerals (including iron and zinc). Processed red meat (ham, sausages, bacon, frankfurters, salami, etc.) undergoes treatment (curing, smoking, salting or the use of chemical preservatives and additives) to improve its shelf life and/or taste. During recent decades, consumption of red meat has been increasing globally, especially in developing countries. At the same time, there has been growing evidence that high consumption of red meat, especially of processed meat, may be associated with an increased risk of several major chronic diseases. Here, a comprehensive summary is provided of the accumulated evidence based on prospective cohort studies regarding the potential adverse health effects of red meat consumption on major chronic diseases, such as diabetes, coronary heart disease, heart failure, stroke and cancer at several sites, and mortality. Risk estimates from pooled analyses and meta‐analyses are presented together with recently published findings. Based on at least six cohorts, summary results for the consumption of unprocessed red meat of 100 g day−1 varied from nonsignificant to statistically significantly increased risk (11% for stroke and for breast cancer, 15% for cardiovascular mortality, 17% for colorectal and 19% for advanced prostate cancer); for the consumption of 50 g day−1 processed meat, the risks were statistically significantly increased for most of the studied diseases (4% for total prostate cancer, 8% for cancer mortality, 9% for breast, 18% for colorectal and 19% for pancreatic cancer, 13% for stroke, 22% for total and 24% for cardiovascular mortality and 32% for diabetes). Potential biological mechanisms underlying the observed risks and the environmental impact of red meat production are also discussed. The evidence‐based integrated message is that it is plausible to conclude that high consumption of red meat, and especially processed meat, is associated with an increased risk of several major chronic diseases and preterm mortality. Production of red meat involves an environmental burden. Therefore, some European countries have already integrated these two issues, human health and the ‘health of the planet’, into new dietary guidelines and recommended limiting consumption of red meat.
Stressors alter intercellular communication and exosome profile of nasopharyngeal carcinoma cells
Authors: Harmati Maria , Tarnai Zsofia , Decsi Gabor , Kormondi Sandor , Szegletes Zsolt , Janovak Laszlo , Dekany Imre , Saydam Okay , Gyukity‐Sebestyen Edina , Dobra Gabriella , Nagy Istvan , Nagy Katalin , Buzas Krisztina 
Published: September 2016

BackgroundHead and neck cancers comprise the sixth most common cancer type worldwide. One of the most remarkable malignancies of the head and neck is the cancer of the nasopharynx, with a strong metastatic tendency already in the early stage. Besides the conventional pathways of metastasis formation, the information content of exosomes produced by the cancer cells may play a key role in metastatic transformation. The aim of this study was to investigate how stressors alter the characteristic of tumor derived exosomes.MethodsIn our experimental model, we compared the quantity and content of exosomes produced by a nasopharyngeal carcinoma cell line (5‐8F) under conventional (chemotherapy) and alternative (Ag–TiO2‐catalyzed reactive oxygen species generation) cytostatic treatment. After isolation, exosomes were identified by atomic force microscopy and quantified with Nanosight NS500 device. MicroRNA content of them was analyzed using SOLiD 5500xl technology. The sequences were annotated in CLC Genomics Workbench version 5.5.1.ResultsBeyond the classic chemotherapeutic agent (doxorubicin), Ag–TiO2 in a photo‐catalytic process also showed cytostatic activity. Tumor cell damage induced by the cytostatic treatments significantly altered the number of released exosomes and led to the predominance of tumor suppressors in the exosomal miRNA profile.ConclusionsOur results suggest that the intercellular communication between tumor cells and surrounding stroma cells can be altered by microenvironment which increased quantity of exosomes and diversity of miRNAs in this study. Imbalance of oncogenic and tumor suppressor miRNAs caused by cytostatic treatments may influence the antiproliferative and metastasis inhibitory effect of cytostatic agents.
Obstructive Sleep Apnea Management: An Overview of the Literature
Authors: AlRumaih Hamad S. , Baba Nadim Z. , AlShehri Abdulkareem , AlHelal Abdulaziz , Al‐Humaidan Abdulkareem 
Published: September 2016

AbstractPurposeDifferent approaches have been proposed to treat obstructive sleep apnea (OSA). This article reviews a synopsis of the available literature regarding the management of OSA.MethodsA comprehensive review of the literature on the management of OSA began with a search of English‐language peer‐reviewed manuscripts using PubMed and MEDLINE. The focus was on clinical research articles published between 1996 and 2016. A search of relevant dental journals was also completed.ResultsOSA can be managed through behavior management, continuous positive airway pressure (CPAP), oral appliances, and other therapies. Clinicians may select treatment modalities based on the severity of clinical presentation and the patient's symptoms.ConclusionStudies showed an enhancement in the quality of life in many patients who have been treated with oral appliances, and patients in general prefer oral appliances over CPAP therapy or any other treatments for OSA because of its convenience.
In Vitro Effectiveness of a Terpenic Denture Cleanser on Old Biofilm Surfaces
Authors: Martínez Alejandra , Catalán Alfonso , Rojas Ninón , Torres Viviana , Acuña Mónica 
Published: September 2016

AbstractPurposeTo assess the effects of terpenic denture cleanser on denture biofilm removal using scanning electron microscopy (SEM).Materials and MethodsThe internal surface biofilm of four maxillary dentures was elucidated with Caristop‐revelador Dual Tone, and 40 blue‐stained specimens (0.6 cm × 0.4 cm × 2 mm) were obtained. These specimens were randomly assigned to one of the following four groups of 10 specimens each: control, Eci Clean, Fitty Dent, and terpenic denture cleanser. The period of immersion in each solution was 12 hours. Biofilm removal was evaluated using SEM, and morphologically varying areas of the SEM images were quantified with Imaris software. The data were analyzed using Kolmogorov‐Smirnov, t‐tests, ANOVA, and Tamhane's tests (p = 0.05).ResultsData revealed that terpenic denture cleanser removed significantly more biofilm than any other treatment examined in this study. The t‐tests revealed significant differences in the clean area that resulted from the use of the terpenic cleanser compared with the clean area that resulted from the use of Eci Clean (p = 0.013). Fitty Dent was the least effective and left dirty acrylic resin. The average areas with few removed layers were 59.3%, 43.3%, and 9.5% in Fitty Dent, Eci Clean, and terpenic cleanser groups, respectively. Tamhane's tests indicated that the Eci Clean and Fitty Dent groups were significantly different from the 0.5% terpenic cleanser group (p = 0.008).ConclusionThe terpenic denture cleanser was effective in removing denture biofilm.
Utility‐based quality of life in mothers of children with behaviour problems: A population‐based study
Authors: Le Ha ND , Gulenc Alisha , Gold Lisa , Sarkadi Anna , Ukoumunne Obioha C , Bayer Jordana , Wake Melissa , Hiscock Harriet 
Published: September 2016

AimTo examine the relationship between mothers’ health‐related quality of life (HRQoL) and child behaviour problems at age 2 years. To investigate whether the relationship between maternal HRQoL and child behaviour problems is independent of maternal mental health.MethodsCross‐sectional survey nested within a population‐level, cluster randomised trial, which aims to prevent early child behaviour problems. One hundred and sixty mothers of 2‐year‐old children, in nine local government areas in Victoria, Australia. HRQoL was measured using the Assessment of Quality of Life 6D and child behaviour was measured using the child behaviour checklist (CBCL/1.5–5 years). Maternal mental health was measured using the Depression Anxiety Stress Scale. Data were collected at child age 2 years; demographic data were collected at child age 8 months.Results
HRQoL was lower for mothers with children that had borderline/clinical behaviour problems compared to those with children without problems (mean difference −0.14, 95% confidence interval (CI): −0.16 to −0.12, P < 0.001). The finding did not markedly change when adjusting for household income, financial security, child gender, child temperament and intervention group status at child age 8 months (mean difference −0.12, 95% CI: −0.15 to −0.09, P < 0.001), but did attenuate when additionally adjusting for concurrent maternal mental health (mean difference −0.03, 95% CI: −0.05 to −0.02, P < 0.001).ConclusionsChild behaviour problems were associated with lower maternal HRQoL. Child behaviour problems prevention programmes could consider this association with maternal HRQoL and be designed to improve and report both mothers’ and their child's health and wellbeing.
Determinants of developmental progress in pre‐schoolers referred for neuro‐developmental diagnosis
Authors: Milne Susan , McDonald Jenny , Kayrouz Norma 
Published: September 2016

AimTo determine factors associated with change in developmental progress in pre‐schoolers referred to a developmental clinic.MethodsOf 360 pre‐schoolers referred to a Child Assessment clinic for neuro‐developmental diagnosis before 3.6 years, 190 (53%) were reassessed prior to school entry and recruited to this study. They were assessed with the Bayley Scales of Infant and Toddler Development (3rd edn) before 3.5 years and the Griffiths Mental Development Scales before school entry. The influence of medical and environmental variables on improvement or deterioration in scores (±0.5 SD) was examined using logistic regression.ResultsConsistent scores were present in 51.6% of children, and associated with environmental variables. Children with stable scores were more likely to live in a suburb of social advantage (OR = 3.2; 95%CI = 1.37–7.64, P = 0.008) or to come from families dependent on welfare or public housing (OR=4.8; 95%CI = 2.19–10.49, P < 0.001). Improvement was seen in 18.1% of children; they were more likely to have commenced therapy after the first assessment (OR = 2.4; 95%CI = 1.05–5.58, P = 0.038). Deterioration of scores was seen in 30% of children. Children with a mild delay on initial assessment were less likely to deteriorate (OR = 2.9; 95%CI = 1.16–7.04, P = 0.022), while lower scores were more likely in children with neuro‐motor disabilities (OR = 10.8; 95%CI = 2.64–44.58, P < 0.001), and chromosomal variations of both known and unknown significance (OR = 4.4; 95%CI = 1.54–12.76, P = 0.006).ConclusionsSocio‐economic advantage and disadvantage are associated with stable scores, but introducing intervention is associated with improved scores. Deterioration is most likely in children with chromosomal variations or neuro‐motor disabilities, and regular reassessment of these children is recommended.
Emotion Regulation and Coping Strategies in Pedagogical Students with Different Attachment Styles
Authors: Prosen Simona , Vitulić Helena Smrtnik 
Published: September 2016

Abstract: Emotion regulation (ER) and coping strategies were compared in 242 pedagogical students from the Faculty of Education, University of Ljubljana, with different attachment styles: secure (51.3%), fearful (31.9%), preoccupied (14.2%), and dismissive (2.7%). The students’ ages ranged from 18 to 24 years (
M
= 19.02;
SD
= .92), and the majority were female (95.0%). They completed three questionnaires assessing their attachment styles and their use of ER and coping strategies. It was determined that the students used the majority of ER and coping strategies sometimes. Somewhat different patterns in the use of ER and coping strategies were, however, present in each attachment‐based group. Significant differences between these groups appeared in their use of the ER strategies of social support, suppression, and comfort eating, and in the coping strategies of seeking social support and escaping or avoiding stressful situations.
Capromorelin increases food consumption, body weight, growth hormone, and sustained insulin‐like growth factor 1 concentrations when administered to healthy adult Beagle dogs
Authors: Zollers B. , Rhodes L. , Smith R. G. 
Published: September 2016

This study's objective was to determine the effects in dogs of oral capromorelin, a ghrelin agonist, at different doses for 7 days on food consumption, body weight and serum concentrations of growth hormone (GH), insulin‐like growth factor 1 (IGF‐1), and cortisol. Adult Beagles (n = 6) were dosed with placebo BID, capromorelin at 3.0 mg/kg SID, 4.5 mg/kg SID, or 3.0 mg/kg BID. Food consumption, body weight, serum capromorelin, GH, IGF‐1, and cortisol were measured at intervals on days 1, 4, 7, and 9. Capromorelin increased food consumption and body weight compared to placebo and caused increased serum GH, which returned to the baseline by 8 h postdose. The magnitude of the GH increase was less on days 4 and 7 compared to Day 1. IGF‐1 concentrations increased on Day 1 in capromorelin‐treated dogs and this increase was sustained through Day 7. Serum cortisol increased postdosing and returned to the baseline concentrations by 8 h. The magnitude of the increase was less on days 4 and 7 compared to Day 1. A dose of 3 mg/kg was chosen for further study in dogs based on this dose causing increased food consumption and sustained IGF‐1 serum concentrations that may increase lean muscle mass when administered over extended periods.