bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mast Cell-Intervertebral disc cell interactions regulate inflammation, catabolism and angiogenesis in Discogenic Back Pain
Authors: Wiet Matthew G. , Piscioneri Andrew , Khan Safdar N. , Ballinger Megan N. , Hoyland Judith A. , Purmessur Devina 
Published: September 2017

AbstractLow back pain (LBP) is a widespread debilitating disorder of significant socio-economic importance and intervertebral disc (IVD) degeneration has been implicated in its pathogenesis. Despite its high prevalence the underlying causes of LBP and IVD degeneration are not well understood. Recent work in musculoskeletal degenerative diseases such as osteoarthritis have revealed a critical role for immune cells, specifically mast cells in their pathophysiology, eluding to a potential role for these cells in the pathogenesis of IVD degeneration. This study sought to characterize the presence and role of mast cells within the IVD, specifically, mast cell-IVD cell interactions using immunohistochemistry and 3Din-vitrocell culture methods. Mast cells were upregulated in painful human IVD tissue and induced an inflammatory, catabolic and pro-angiogenic phenotype in bovine nucleus pulposus and cartilage endplate cells at the gene level. Healthy bovine annulus fibrosus cells, however, demonstrated a protective role against key inflammatory (IL-1β and TNFα) and pro-angiogenic (VEGFA) genes expressed by mast cells, and mitigated neo-angiogenesis formationin vitro. In conclusion, mast cells can infiltrate and elicit a degenerate phenotype in IVD cells, enhancing key disease processes that characterize the degenerate IVD, making them a potential therapeutic target for LBP.
1, 25(OH)2 D3 Induces Reactivation and Death of Kaposi’s Sarcoma-Associated Herpesvirus of Primary Effusion Lymphoma cells
Authors: Kumar Amit , Mohanty Suchitra , Das Piyanki , Sahu Sushil Kumar , Rajasubramaniam Shanmugam , Choudhuri Tathagata 
Published: September 2017

AbstractKaposi’s sarcoma associated herpesvirus (KSHV) a gammaherpesvirus establishes perennial latency in the host with periodic reactivation. Occasionally change in the physiological condition like hypoxia, host cell differentiation can trigger the lytic switch and reactivation of the virus. The biologically active form of 1, 25(OH)2 D3 plays a critical role in the regulation of various physiological processes (e.g. regulation of mineral homeostasis and control of bone metabolism). Apart from its role in host physiology, 1, 25(OH)2 D3 has been implicated as a potential agent for the prevention and/or treatment of many a tumors. Here we show that 1, 25(OH)2 D3 induces both death of Kaposi sarcoma associated herpesvirus infected PEL cells and KSHV replication. 1, 25(OH)2 D3 mediated inhibition of proliferation was associated with apoptosis of the PEL cells, and virus reactivation. In addition, p38 signalling is required for KSHV reactivation. Furthermore, treatment of PEL cells with p38 inhibitor abrogated the expression of ORF57, thus blocking lytic switch. Furthermore, silencing of VDR resulted in reduced ORF57 expression compared to the control cells, signifying the potential role of 1, 25(OH)2 D3 in KSHV reactivation. Thus, our studies have revealed a novel role of 1, 25(OH)2 D3 in the regulation of KSHV reactivation and PEL cell death.
X-ray microbeam measurements with a high resolution scintillator fibre-optic dosimeter
Authors: Archer James , Li Enbang , Petasecca Marco , Dipuglia Andrew , Cameron Matthew , Stevenson Andrew , Hall Chris , Hausermann Daniel , Rosenfeld Anatoly , Lerch Michael 
Published: September 2017

AbstractSynchrotron microbeam radiation therapy is a novel external beam therapy under investigation, that uses highly brilliant synchrotron x-rays in microbeams 50 μm width, with separation of 400 μm, as implemented here. Due to the fine spatial fractionation dosimetry of these beams is a challenging and complicated problem. In this proof-of-concept work, we present a fibre optic dosimeter that uses plastic scintillator as the radiation conversion material. We claim an ideal one-dimensional resolution of 50 μm. Using plastic scintillator and fibre optic makes this dosimeter water-equivalent, a very desirable dosimetric property. The dosimeter was tested at the Australian Synchrotron, on the Imaging and Medical Beam-Line. The individual microbeams were able to be resolved and the peak-to-valley dose ratio and the full width at half maximum of the microbeams was measured. These results are compared to a semiconductor strip detector of the same spatial resolution. A percent depth dose was measured and compared to data acquired by an ionisation chamber. The results presented demonstrate significant steps towards the development of an optical dosimeter with the potential to be applied in quality assurance of microbeam radiation therapy, which is vital if clinical trials are to be performed on human patients.
Magmatic tempo of Earth’s youngest exposed plutons as revealed by detrital zircon U-Pb geochronology
Authors: Ito Hisatoshi , Spencer Christopher J. , Danišík Martin , Hoiland Carl W. 
Published: September 2017

AbstractPlutons are formed by protracted crystallization of magma bodies several kilometers deep within the crust. The temporal frequency (i.e. episodicity or ‘tempo’) of pluton formation is often poorly constrained as timescales of pluton formation are largely variable and may be difficult to resolve by traditional dating methods. The Hida Mountain Range of central Japan hosts the youngest exposed plutons on Earth and provides a unique opportunity to assess the temporal and spatial characteristics of pluton emplacement at high temporal resolution. Here we apply U-Pb geochronology to zircon from the Quaternary Kurobegawa Granite and Takidani Granodiorite in the Hida Mountain Range, and from modern river sediments whose fluvial catchments include these plutons in order to reconstruct their formation. The U-Pb data demonstrate that the Kurobegawa pluton experienced two magmatic pulses at ~2.3 Ma and ~0.9 Ma; whereas, to the south, the Takidani pluton experienced only one magmatic pulse at ~1.6 Ma. These data imply that each of these magmatic systems were both spatially and temporally distinct. The apparent ~0.7 Myr age gap between each of the three magmatic pulses potentially constrains the recharge duration of a single pluton within a larger arc plutonic complex.
Genetic connection between cell-wall composition and grain yield via parallel QTL analysis in indica and japonica subspecies
Authors: Xu Zuopeng , Li Shance , Zhang Changquan , Zhang Baocai , Zhu Kongzhi , Zhou Yihua , Liu Qiaoquan 
Published: September 2017

AbstractGrain yield is a complicated trait, which is highly associated with biomass productivity. The cell wall is a central element of biomass, and its biogenesis contributes to plant architecture and development. However, the genetic link between cell-wall property and grain yield is largely unclear. Here, we report on identification of quantitative trait loci (QTLs) for grain yield-related traits and cell-wall composition with a set of chromosomal segment substitution lines (CSSLs) that were generated by using 9311, an indica cultivar as donor, and Nipponbare, a japonica cultivar as recipient. Nipponbare and 9311 showed significant differences in grain yield-related traits and cell-wall composition. Genotyping with molecular markers, 125 lines covering 95.6% of the whole genome of 9311 were employed for phenotypic and chemical examinations. Thirty-seven QTLs for grain yield-related traits and nineteen QTLs for cell-wall composition have been identified. In addition to correlation analysis, we found overlapped and closely linked QTLs for two sets of traits. Fine-mapping further narrowed a QTL for cellulose content together with HD17, a known QTL for heading date and grain yield, suggesting that plants may regulate cell wall biogenesis and grain yield via related means. Our study provided genetic clues for cloning QTLs for both complicated traits.
Relationship Between Gestational Weight Gain and Pregnancy Complications or Delivery Outcome
Authors: Yang Wenjia , Han Feifei , Gao Xueying , Chen Yifei , Ji Linong , Cai Xiaoling 
Published: September 2017

AbstractThe purpose of this study is to analyse the association between gestational weight gain and delivery outcome or the morbidity of pregnancy complications. A total of 1,102 pregnant women who delivered at Peking University People’s Hospital in China between January 2011 and December 2012 were included in this study. We divided them into 4 groups according to the baseline BMI quartiles and weight gain quartiles in different trimesters of pregnancy to analyse the status of delivery outcome and morbidity of pregnancy complications. Baseline BMI was significantly positive correlated with the morbidity of gestational hypertension and gestational diabetes. Weight gain in the second trimester of pregnancy was significantly positively correlated with the morbidity of macrosomia. Weight gain in the third trimester of pregnancy showed significantly positive correlation with the morbidity of macrosomia, and significantly negative correlation with the morbidity of neonatal death, preterm birth, gestational diabetes, and low birth-weight infant. Gestational weight gain showed significantly positive correlation with the morbidity of macrosomia and significantly negative correlation with neonatal death, stillbirth, gestational diabetes, preterm birth and low birth-weight infant. There is a correlation between baseline BMI, pregnancy weight gain and gestational complications, adverse pregnancy outcomes, and status of neonate in varying degrees.
Exploration of changes in the brain response to sleep-related pictures after cognitive–behavioral therapy for psychophysiological insomnia
Authors: Kim Seog Ju , Lee Yu Jin , Kim Nambeom , Kim Soohyun , Choi Jae-Won , Park Juhyun , Gwak Ah Reum , Kang Chang-Ki , Kang Seung-Gul , Jeong Do-Un 
Published: September 2017

AbstractPsychophysiological insomnia (PI) includes arousal to sleep-related stimuli (SS), which can be treated by cognitive behavioral therapy for insomnia (CBT-I). The present study was an exploratory, prospective intervention study that aimed to explore brain response to visual SS in PI before and after CBT-I. Blood oxygen level dependent (BOLD) signal differences in response to SS and neutral stimuli (NS) were compared between 14 drug-free PI patients and 18 good sleepers (GS) using functional magnetic resonance imaging (fMRI). BOLD changes after CBT-I in patients were also examined. PI patients showed higher BOLD activation to SS in the precentral, prefrontal, fusiform, and posterior cingulate cortices before CBT-I. The increased responses to SS were reduced after CBT-I. The increased response to SS in the precentral cortex was associated with longer wake time after sleep onset (WASO), and its reduction after CBT-I was associated with improvements in WASO. Clinical improvements after CBT-I were correlated with BOLD reduction in the right insula and left paracentral cortex in response to SS. PI showed hyper-responses to SS in the precentral cortex, prefrontal cortex, and default mode network and these brain hyper-responses were normalized after CBT-I. CBT-I may exert its treatment effects on PI by reducing hyper-responses to SS in the precentral cortex and insula.
Three-dimensional image reconstruction of distribution of Pnmt+ cell-derived cells in murine heart
Authors: Ni Haibo , Wang Yange , Crawford William , Zhang Shanzhuo , Cheng Longxian , Zhang Henggui , Lei Ming 
Published: September 2017

AbstractElucidating the function of specific cell types in a highly complex multicellular system such as the heart often requires detailed anatomic reconstruction. We recently described a distinctive class of phenylethanolamine n-methyltransferase (Pnmt+) cell-derived cardiomyocytes (PdCMs), a new cardiomyocyte population with a potential endocrine role. In this dataset, a 3D reconstruction was carried out to visualise the distribution of PdCMs throughout the murine heart. Rigid registration (stiff rotation and translation) was applied to properly align the fused heart slice images based on landmarks using TrakEM2, an open source plug-in in Fiji. The registered slices were then analysed and reconstructed using MATLAB (MATLAB®. Version 8.3.0.532). The final reconstructed 3D volume was 561×866×48 pixels (corresponding to spatial resolutions of 5.8, 8.9 and 2.5 mm in the x-, y- and z-direction respectively), and visualised in Paraview. The reconstruction allows for detailed analyses of morphology, projections and cellular features of different cell types, enabling further geometrical and topological analyses. Image data can be accessed and viewed through Figshare.
Oscillator with tunable phase capability
Authors: Maundy B.J. , Elwakil A.S. , Elamien M.B. 
Published: September 2017

A novel four‐output oscillator based on cross‐coupled differential pairs is introduced and its validity is verified experimentally using discrete transistors as well as by simulations in a 90 nm CMOS technology. This oscillator has the unique capability of phase tunabililty where the phase shift between two of its outputs can be a design parameter while the phase shift between the other two outputs is always .
Effect of secondary discharge on the repeatability of contact discharge method
Authors: Wan Fayu , Wang Xiangwei , Li Binhong 
Published: September 2017

Submillimetre gaps caused by buttons, switches exist in the electronic device. IEC 61000‐4‐2 indicates that contact discharge method will be used if these floating metals could be touched in its normal use. Secondary discharge happens when conduct contact discharge on these floating metals. The influence of the secondary discharge on the repeatability of contact discharge method using experimental method is analysed. At same applied voltage, the secondary discharge current varies largely, causing bad repeatability. The time lag is the main parameter that influences the secondary discharge greatly. The time lag distribution is also analysed.
Virtual Element Method for the Laplace-Beltrami equation on surfaces
Authors: Frittelli Massimo , Sgura Ivonne 
Published: September 2017

We present and analyze a Virtual Element Method (VEM) for the Laplace-Beltrami equation on a surface in ℝ3, that we call Surface Virtual Element Method (SVEM). The method combines the Surface Finite Element Method (SFEM) (Dziuk, Eliott, G. Dziuk and C.M. Elliott., Acta Numer. 22 (2013) 289–396.) and the recent VEM (Beirão da Veiga et al., Math. Mod. Methods Appl. Sci. 23 (2013) 199–214.) in order to allow for a general polygonal approximation of the surface. We account for the error arising from the geometry approximation and in the case of polynomial order k = 1 we extend to surfaces the error estimates for the interpolation in the virtual element space. We prove existence, uniqueness and first order H1 convergence of the numerical solution.We highlight the differences between SVEM and VEM from the implementation point of view. Moreover, we show that the capability of SVEM of handling nonconforming and discontinuous meshes can be exploited in the case of surface pasting. We provide some numerical experiments to confirm the convergence result and to show an application of mesh pasting.
The Emergence of Classical Homoeopathy as Opposed to the Later Hahnemannian Approach
Authors: Roy Ravi 
Published: September 2017

AbstractCuriously, classical homoeopathy has departed from the unalloyed homoeopathy which Hahnemann developed. The actual discrepancies between Hahnemann's homoeopathy and classical homoeopathy are astounding. The distinction began with the theory of chronic diseases, the miasms, that Hahnemann put forward in 1828. This led to the ignoring of the rules and principles he laid down in his work, The Chronic Diseases. Since then, classical homoeopaths have disregarded the later works of Hahnemann and have adhered to the earlier editions of The Organon. Hering's practice does not confirm to the principles and rules laid down by Hahnemann in The Chronic Diseases, even though Hering praises the genius of Hahnemann's theory of the miasms. He also propagated classical homoeopathy in America; therefore, the last and very fruitful 15 years of Hahnemann's research remains widely unaccounted for in the English literature. The cleft in Germany between classical and Hahnemannian homoeopathy started in the 1830s and the magazine Die Allgemeine Homöopathische Zeitung became the journal for classical homoeopathy. These classical homoeopaths laid down the fundamentals of the homoeopathy they adhered to, and Hahnemann's homoeopathy went into the shadows; it was practised by a very few. Now it is time to revive Hahnemann's homoeopathy and remind people of his extraordinary insights and of their effectiveness.
Health Information Management: Changing with Time
Authors: Fenton S. H. , Low S. , Abrams K. J. , Butler-Henderson K. 
Published: September 2017

Summary
Objective: With the evolution of patient medical records from paper to electronic media and the changes to the way data is sourced, used, and managed, there is an opportunity for health information management (HIM) to learn and facilitate the increasing expanse of available patient data.
Methods: This paper discusses the emerging trends and lessons learnt in relation with the following four areas: 1) data and information governance, 2) terminology standards certification, 3) International Classification of Diseases, 11th edition (ICD-11), and 4) data analytics and HIM.
Results: The governance of patient data and information increasingly requires the HIM profession to incorporate the roles of data scientists and data stewards into its portfolio to ensure data analytics and digital transformation is appropriately managed. Not only are terminology standards required to facilitate the structure and primary use of this data, developments in Canada in relation with the standards, role descriptions, framework and curricula in the form of certification provide one prime example of ensuring the quality of the secondary use of patient data. The impending introduction of ICD-11 brings with it the need for the HIM profession to manage the transition between ICD versions and country modifications incorporating changes to standards and tools, and the availability and type of patient data available for secondary use.
Conclusions: In summary, the health information management profession now requires abilities in leadership, data, and informatics in addition to health information science and coding skills to facilitate the expanding secondary use of patient data.
Contributions from the 2016 Literature on Clinical Decision Support
Authors: Koutkias V. , Bouaud J. 
Published: September 2017

Summary
Objectives: To summarize recent research and select the best papers published in 2016 in the field of computerized clinical decision support for the Decision Support section of the IMIA yearbook.
Methods: A literature review was performed by searching two bibliographic databases for papers related to clinical decision support systems (CDSSs). The aim was to identify a list of candidate best papers from the retrieved papers that were then peer-reviewed by external reviewers. A consensus meeting of the IMIA editorial team finally selected the best papers on the basis of all reviews and section editor evaluation.
Results: Among the 1,145 retrieved papers, the entire review process resulted in the selection of four best papers. The first paper describes machine learning models used to predict breast cancer multidisciplinary team decisions and compares them with two predictors based on guideline knowledge. The second paper introduces a linked-data approach for publication, discovery, and interoperability of CDSSs. The third paper assessed the variation in high-priority drug-drug interaction (DDI) alerts across 14 Electronic Health Record systems, operating in different institutions in the US. The fourth paper proposes a generic framework for modeling multiple concurrent guidelines and detecting their recommendation interactions using semantic web technologies.
Conclusions: The process of identifying and selecting best papers in the domain of CDSSs demonstrated that the research in this field is very active concerning diverse dimensions, such as the types of CDSSs, e.g. guideline-based, machine-learning-based, knowledge-fusion-based, etc., and addresses challenging areas, such as the concurrent application of multiple guidelines for comorbid patients, the resolution of interoperability issues, and the evaluation of CDSSs. Nevertheless, this process also showed that CDSSs are not yet fully part of the digitalized healthcare ecosystem. Many challenges remain to be faced with regard to the evidence of their output, the dissemination of their technologies, as well as their adoption for better and safer healthcare delivery.
Knowledge Representation and Management, It’s Time to Integrate!
Authors: Dhombres F. , Charlet J. 
Published: September 2017

Summary
Objectives: To select, present, and summarize the best papers published in 2016 in the field of Knowledge Representation and Management (KRM).
Methods: A comprehensive and standardized review of the medical informatics literature was performed based on a PubMed query.
Results: Among the 1,421 retrieved papers, the review process resulted in the selection of four best papers focused on the integration of heterogeneous data via the development and the alignment of terminological resources. In the first article, the authors provide a curated and standardized version of the publicly available US FDA Adverse Event Reporting System. Such a resource will improve the quality of the underlying data, and enable standardized analyses using common vocabularies. The second article describes a project developed in order to facilitate heterogeneous data integration in the i2b2 framework. The originality is to allow users integrate the data described in different terminologies and to build a new repository, with a unique model able to support the representation of the various data. The third paper is dedicated to model the association between multiple phenotypic traits described within the Human Phenotype Ontology (HPO) and the corresponding
genotype in the specific context of rare diseases (rare variants). Finally, the fourth paper presents solutions to annotation-ontology mapping in genome-scale data. Of particular interest in this work is the Experimental Factor Ontology (EFO) and its generic association model, the Ontology of Biomedical AssociatioN (OBAN).
Conclusion: Ontologies have started to show their efficiency to integrate medical data for various tasks in medical informatics: electronic health records data management, clinical research, and knowledge-based systems development.