bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predicting Collapse of a Lattice Dome Due to Foundation Settlement
Authors: Shugar T.A. , Holland T.J. 
Published: January 2017

The base of the lattice dome sheltering the Amundsen-Scott South Pole Station is distorting due to movement in the compacted snow foundation. The base ring differential settlement is calculated by a least squares analysis of measured foundation displacement data. The topology and geometry of the dome have been reconstructed, and a one-to-one correspondence exists between the modeled and actual latticed framework. A structural model based on bending elements is employed and its development is discussed relative to an alternative, non-bending model. Practical structural analysis issues for predicting collapse of a lattice dome due to settlement using modern computer methods are discussed. Attempts to calculate post-buckled configurations and the collapse load of the structure were only partially successful. However, application of these methods to the South Pole Dome show that it is in satisfactory condition at its present level of differential settlement.
Torus Gesto Space Structure System
Authors: Georgievski Vladimir 
Published: January 2017

The paper presents the details of the TORUS GESTO system of space structures developed in the Institute of Welding and Welded Constructions at the Department for Metal Structures at the Faculty of Mechanical Engineering, Skopje, Yugoslavia. It contains a brief description of a recent application of a new system of construction used for a large storage hall and discusses the advantages and disadvantages of the system. After the details of the development of the TORUS GESTO jointing system, the article deals briefly with the production technology, erection procedures and full-size tests of space structures constructed in this system.
Tensegrity Systems and Geodesic Domes
Authors: Motro R. 
Published: January 2017

The name Buckminster Fuller is associated with the development of geodesic domes and with tensegrity systems. The principle of the latter is that rigidity is obtained by selfstressing alone. The shapes of domes constructed using tensegrity systems are not generally known a priori; these domes belong to the class of systems with indeterminate shape, such as cable systems. A form-finding method using the dynamic relaxation technique with attenuation of kinetic energy is presented here. The results given by this general method are compared with known solutions in certain cases and make it possible to quantify the deviations between geometries of tensegrity systems and polyhedral geometries. An example is given to illustrate the possibilities of the combination of the principle of tensegity systems with that of geodesic domes. It is a double-layer, double-curvature system whose shape respects the selfstressing criterion. Industrial construction of the system can be envisaged thanks to the design of an assembly node which permits variations in curve radius.
A Study of Morphological Characteristics of Tensegrity Structures
Authors: Chassagnoux A. , Chomarat A. , Savel J. 
Published: January 2017

Tensegrity structures have a special place in the structures classification. Some developments by D.G. Emmerich on their morphology show their important diversity in their geometrical configurations. In this study, the authors describe the mathematical relationships that determine the spatial organisation of the tensegrity structures components and demonstrate that these structures represent the particular characteristics at the origin of mechanisms which transform themselves into stable structures as soon as they are loaded.
Thin Sheet Metal (Membrane) Suspended Roof Structures
Authors: Yeremeyv P.G. , Kiselev D.B. 
Published: January 2017

A membrane roof is a three-dimensional system of thin metal sagging sheets fastened along the perimeter to the supporting contour. The membrane can form the roof of buildings and structures of various shapes of the surface and in-plan outlines with spans of 18 to 300 m. The longer the span the higher the economic efficiency of the membranes, the thickness of which is as low as 1 to 5 mm. The distinctive features of the structure are the most complete use of strength properties of a thin sheet in compression and the continuation in one material of load bearing and enclosure functions. Such a structure is able to resist all types of force actions, wind and seismic ones being among them. The thin-sheet roof are easy to manufacture and erect. The membrane structures are intended for civil and industrial buildings. At present a wide complex of theoretical and experimental studies of the membrane structures is being carried out.
Preliminary Results of PTFE Patch Saphenoplasty to Prevent Neovascularization Leading to Recurrent Varicose Veins
Authors: Earnshaw J. J. , Davies B. , Harradine K. , Heather B. P. 
Published: January 2017

Objective: Recurrence is common after varicose vein surgery. Neovascularization may be one cause of recurrent veins. This was a study of PTFE patch saphenoplasty to try and prevent recurrent veins. Design and setting: Prospective cohort study of patients treated in a vascular surgical unit. Patients and interventions: Fifty patients having surgery for symptomatic long saphenous varicose veins (66 legs, 51 primary and 15 recurrent veins) had a PTFE patch sutured over the saphenous opening after flush saphenofemoral ligation. Main outcome measures: The rate of varicose vein recurrence and neovascularization 1 year after surgery were determined using clinical examination and venous duplex imaging. Results: Forty patients (80%) remained pleased with the results of their surgery. Recurrent veins were visible in 14 (21%) legs: 10 were principally due to neovascularization, two to sapheno-popliteal incompetence and two to an incompetent mid-thigh perforating vein. Three other legs had neovascularization but no recurrent veins. Both recurrent veins (47% versus 14%) and neovascularization (40% versus 14%) were significantly more common in patients having surgery for recurrent veins. Conclusions: PTFE patching was safe but did not abolish neovascularization. Neovascularization was the principal cause of recurrent veins in this study and perseverance with investigations into other barrier methods is worthwhile.
The Clinical and Histological Effects of Ethanolamine in Varicose Veins
Authors: Mosley J. G. , Gupta I. 
Published: January 2017

Objective: To study the histological changes in varicosities after injection of 5% ethanolamine. Design: A prospective study in nine groups of six patients awaiting bilateral varicose vein surgery. Patients: Each patient had a below-knee incompetent perforating vein injected with either 0.5, 1.0 or 2.0 ml 5% ethanolamine. The contralateral varicosity received a similar volume of normal saline. Intervention: The patients wore elasticated stockings until admitted for operation at 2, 4 or 8 weeks after the injections. The injected varicosity was then dissected out. Main outcome measures: Each vein was reported on by a histologist who did not know which had received ethanolamine or saline. The histologist graded each vein according to the severity of change from 0 (no effect) to 5 (total obliteration of vein). Results: Ethanolamine at 0.5, 1.0 and 2.0 ml caused extensive histological damage to the varicosity. After 8 weeks most varicosities had been destroyed. Conclusion: Ethanolamine, unlike sodium tetradecyl sulphate, causes complete destruction of a varicosity. A dose of 0.5 ml is just as effective as 2.0 ml.
Neonatal Renal Vein Thrombosis: Report of a Case
Authors: Bohórquez-Sierra J. C. , Calvo-López M. J. , Martínez-León J. I. , Rodríguez-Piñero M. , Arribas-Aguilar F. , Bohórquez-Sierra C. 
Published: January 2017

Objective: To report a case of neonatal renal vein thrombosis diagnosed by duplex scan and treated successfully with intravenous heparin. Design: Case report. Setting: Angiology and Vascular Surgery Unit, Hospital Universitario Puerta del Mar, Cádiz, Spain. Interventions: Conservative treatment with short-term intravenous heparin. Conclusions: Colour Doppler imaging rapidly assesses flow within the renal veins and inferior vena cava, and should be used as the first line of investigation in evaluating venous thrombosis in the neonatal period. In view of the few reports in the literature assessing the different therapeutic modalities of this entity, we advocate short-term anticoagulation in unilateral renal vein thrombosis in the newborn.
Treatment of Moderately Severe Essential Hypertension in General Practice with a Combination of Cyclopenthiazide with Potassium Chloride (Navidrex K) and Oxprenolol (Trasicor 80mg): A Report on 554 Patients
Authors: Forrest W A 
Published: January 2017

Five hundred and fifty-four patients, with an initial mean diastolic pressure of 130 mm Hg, were treated with a combination of Navidrex K ( 0·5 mg daily) and up to 480 mg (six tablets daily) of Oxprenolol (Trasicor 80 mg). In 69% of this group, good control of the blood pressure was achieved with a daily dose of four tablets ( 320 mg) of Oxprenolol. In the remainder of patients significant reductions in blood pressure levels were noted, again with a mean dose of less than 320 mg daily of oxprenolol. There were indications in this group that better control of blood pressure levels might have been reached, had more of the patients been prescribed the maximum dose of 480 mg daily (six tablets) permitted in the study. Tolerability of this regime was very good. More than 80% of patients reported no side-effects at all, and one patient in four reported ‘feeling better’ after treatment.
A Double-Blind Parallel-Group Comparison of Single Bedtime Doses of Halazepam and Placebo
Authors: McEvilly James P , Etemad Bijan 
Published: January 2017

A single bedtime dose of 120 mg of halazepam was effective in the treatment of patients with mild to moderate anxiety. This dose was superior to both placebo and a 60 mg dose in this 2-week study, as shown by both physician and patient rating scales. The safety of single bedtime doses of halazepam was confirmed. All the reported side-effects were known adverse experiences to benzodiazepines in general.
Quantitative Thermal Imaging to Assess Inositol Nicotinate Treatment for Raynaud's Syndrome
Authors: Ring E F J , Porto L O , Bacon P A 
Published: January 2017

The objective assessment of thermography was used to quantify the response to cold stress in the hands of sufferers from Raynaud's Syndrome over a period of 36 weeks while on inositol nicotinate (Hexopal) in a dose of 4 g per day. Objective improvement was observed in the thermal gradient of the hand after cold challenge (RTG) following this sustained treatment. Statistically significant improvements were noted on four of the five subjective assessments. No drug-related adverse reactions were noted.
Rimactan Parenteral Formulation in Clinical Use
Authors: Kissling M , Xilinas M 
Published: January 2017

One hundred and forty-nine mainly critically ill or comatose patients or patients with problems of gastro-intestinal tolerability and/or absorption have been treated during the last few years with a parenteral formulation of rifampicin made available for release in special cases, on humanitarian grounds. The cases reported include ninety-seven tuberculous patients (eighteen of whom were suffering from tubercular meningitis) and fifty-two patients suffering from non-tuberculous infections, including twenty-two cases of sepsis (fifteen due to staphylococci), four cases of bacterial meningitis and four cases of Legionnaires' disease. R ifampicin was administered in each case, together with at least one other suitable antibacterial agent, mainly by intravenous bolus injection (seventy-four cases) or intravenous drip infusion (forty-four cases), at daily doses ranging from 150 to 1800 mg. The duration of treatment ranged from 1 to 113 days. Data allowing an assessment of effectiveness were made available for sixty-eight tuberculous patients, sixty-three of which (92.6%) showed favourable results, and for twenty-seven patients with non-tuberculous infections, nineteen of which (70.4%) had a favourable outcome. Especially favourable were the results in the cases of staphylococcal sepsis (78.6% of clinical and/or bacteriological cures). Tolerability was good in most cases. Only fourteen of the 149 patients showed signs of local intolerability (thrombo-phlebitis), almost always occurring in patients treated for over 60 days. Fifteen patients (10%) complained of systemic unwanted effects, the relationship of which to the treatment was not always established. Treatment was finally withdrawn because of tolerability problems in only three of the 149 cases (2%). Bearing in mind the very varied nature of the severe, life-threatening infections reported here, two comments may be made: Intravenous rifampicin is useful and even life-saving in both severe tuberculous and non-tuberculous infections. It is safe even in long-term administration. However, treatments lasting over 30–60 days appear to involve a higher risk of venous thrombo-phlebitis.
The Treatment of Hypertension in Older Patients: A Double-Blind, Between-Patient Study in Previously Treated Patients Comparing a Diuretic, a Beta-Receptor Antagonist, and Their Fixed Combination
Authors: Forrest W A 
Published: January 2017

Six hundred and forty-eight previously treated hypertensive patients, with a mean age of 64 years, were studied. In spite of treatment over a mean period of 18 months, their blood pressure was inadequately controlled, with an initial mean level of 180/108 mm Hg. Previous treatment which had consisted of either a diuretic alone, a beta-receptor antagonist alone or these two drugs in combination was discontinued and Datients were randomly allocated, in a double-blind manner, to a 6-week treatment course of cyclopenthiazide (Navidrex®) or sustained release oxprenolol (Slow-Trasicor®) or a fixed combination of these two compounds (Trasidrex®) with the aim of lowering the diastolic pressure to < 100 mm Hg. Blood pressure was substantially reduced in each treatment group, with the lowest final pressures in the group treated with the fixed combination, where 87% of the patients completing the study reached the target level of a diastolic pressure of < 100 mm Hg. Very few side-effects of treatment were reported with any of these compounds. The results from this study suggest that these compounds in their standard dosage range are useful and safe antihypertensive agents in older patients. In those patients where blood pressure control with a single agent was proving difficult, the transfer to one or two tablets daily of the fixed combination (Trasidrex) produced a very satisfactory outcome in the large majority of cases.
A Double-Blind Comparison of Flurbiprofen and Indomethacin Suppositories in the Treatment of Osteoarthrosis and Rheumatoid Disease
Authors: De Moor M , Ooghe R 
Published: January 2017

Forty patients with osteoarthrosis or rheumatoid arthritis were entered in a 4-week double-blind trial to compare the efficacy, safety and tolerance of a flurbiprofen 100 mg suppository formulation with indomethacin 100 mg suppositories. There were twenty patients each on indomethacin and flurbiprofen. Statistically significant improvements were reported for both treatments during the study with respect to morning stiffness, night pain and the overall progress of the patients. Both treatments were equally effective with respect to the amount of improvement shown for the parameters. No improvement was noted on either treatment with respect to grip-strength, functional capacity or the daily intake of analgesic therapy, while a marginally significant decrease in the erythrocyte sedimentation rate was noted on indomethacin. Both treatments were well tolerated with only a few transient and mild side-effects being reported. On the basis of this trial, flurbiprofen and indomethacin suppositories have equal therapeutic effects in the treatment of night pain and morning stiffness.
Analgesia following Adult Tonsillectomy: A Comparative Study of Solpadeine and a Soluble Form of Dextropropoxyphene Napsylate and Paracetamol
Authors: Mac Kay I S , Ananian V 
Published: January 2017

A single-centre, single-blind, between-patient study was carried out to compare the effectiveness and tolerability of Solpadeine and a soluble form of dextropropoxyphene napsylate and paracetamol (DNP) in the alleviation of pain following bilateral tonsillectomy in adult patients. Patients were randomly allocated to receive either two Solpadeine or two DNP 6-hourly over a period of 3 days starting on the day after the operation. The clinician assessed the patients' condition at the time of operation and again at the end of the 3-day treatment period. The patients determined the onset of analgesic action using visual analogue scales and also recorded the severity of their pain at various times during the day. Seventy-four results were analyzed. Twenty per cent of those receiving Solpadeine were considered by the clinician to have excellent pain relief compared with only 8·8% on DNP. On Day 2, 51·3% of patients on Solpadeine described their pain relief as good or excellent in comparison with 37·5% on DNP. However, these differences were not statistically significant. It is concluded that Solpadeine and DNP are both effective analgesics in relieving post-tonsillectomy pain, but that Solpadeine achieves a greater degree of good or excellent pain relief and is, therefore, to be preferred.
Single Dose Treatment of Trichomoniasis
Authors: Gabriel G , Robertson E , Thin R N T 
Published: January 2017

Oral treatment for trichomonas vaginalis infection is now well established. In a previous paper, we established the value of a high single dose regimen of metronidazole for this condition by demonstrating its efficacy in a double-blind controlled study. Tinidazole is another accepted trichomonacide. By means of a single-blind controlled trial, we demonstrate that a 2 g single dose of tinidazole is as effective as a 2 g single dose metronidazole in the treatment of vaginal trichomoniasis. The cure rate for tinidazole was 95% and for metronidazole it was 97·5%. No side-effects were reported with either regimen.
Report on a Double-Blind Comparison of Two Different Regimens of Dothiepin (Prothiaden)
Authors: Boening J 
Published: January 2017

Thirty patients diagnosed as suffering from endogenous depression were entered into a 3-week double-blind trial comparing three times a day dosage of dothiepin with a single night-time dosage in a dosage range of 75 mg to 225 mg per day. The trial was conducted on in-patients and assessments were made pretrial and after 1 and 3 weeks. The patients were assessed by clinician-rated scales for psychomotor and psychic symptoms and by Zung's self-rating scale. Fifteen patients received dothiepin three times a day (day-time group) and fifteen received it as a single night-time dose (node group). There were two withdrawals in the day-time group and three in the node group. All withdrawals were due to lack of therapeutic effect. Over the 3-week trial 67% of the day-time group and 47% of the node group showed a clinical improvement. It was found that there was no statistically significant difference between the two methods of treatment. In the day-time group seven patients and in the night-time group nine patients suffered from side-effects. No particular pattern of side-effects emerged. There were no drug-related changes in the laboratory results. It was concluded that the therapeutic effect of both dosage regimes should be regarded as equivalent. Advantages, due to the specific action of dothiepin, compared with classical antidepressants for reference, could, however, not be presumed by the clinical impression.
A Comparative Study of the Therapeutic Effect of Dithranol Cream 0·1% and 0·25% with That of Dithranol Stylus 0·1% and 0·2% in the Treatment of Psoriasis
Authors: Gisslèn H , Nordin P 
Published: January 2017

In Dithranol cream the oily phase is emulsified with an aqueous phase to make the preparation more convenient to apply. The cream also contains ascorbic acid as an antioxidant, which protects dithranol against atmospheric oxidation, thus increasing its stability. A stylus containing dithranol, ol. cacao, paraffin and vaselinum has been used as a comparative drug. The stylus is routinely used in this clinic. Sixty patients with stable psoriasis were pre-assigned into two treatment groups, receiving at random Dithranol cream 0·1%, 0·25% and Dithranol stylus 0·1%, 0·2%, respectively. Both groups started their treatment with the 0·1% preparation once a day for 2 weeks followed by the 0·2% or 0·25% preparations once a day for another 2 weeks. The following laboratory tests: Hb, WBC, Diff, S-ALAT, S-ASAT and S-creatinine were recorded before and after treatment. Staining of clothes was none to slight in 70% (21/30) of the patients using Dithranol stylus 0·2%, and 80% (24/30) in the patients using Dithranol cream 0·25%. The sensation of burning was none to slight in 83% (25/30) of the patients and skin discolouration was none to slight in approximately 80% (24/30) of the patients using the Dithranol stylus 0·2% and Dithranol cream 0·25% preparations. Both groups showed significant improvement in all effect-variables after 2 and 4 weeks' treatment compared to initial. The results are over all better after 4 weeks' treatment than after 2. No abnormal values due to dithranol treatment could be found in the laboratory tests.
Treatment of HBeAg-Positive Chronic Hepatitis with a Streptococcal Preparation (OK-432)
Authors: Ichida F , Yoshikawa A , Yachi A , Goto Y , Furuta S , Hattori N , Kakumu S , Kosaka Y , Takino T , Nagashima H , Tsuji T , Ota Y 
Published: January 2017

Forty-two patients with hepatitis Be antigen (HBeAg)-positive chronic hepatitis were treated by intramuscular injections with OK-432, an immunopotentiator possessing interferon-inducing activity. They were monitored with serial measurements of virological parameters to evaluate therapeutic effectiveness, and compared with a group of seventy-five untreated patients (natural course group). In the group receiving OK-432 therapy, twenty-seven patients (64·3% of the forty-two patients) became negative for HBeAg in an average observation period of 20·1 months. Of these, fourteen patients (33·3% of the forty-two patients) underwent seroconversion from HBeAg to anti-HBe antibody (anti-HBe). In the natural course group, twenty-three patients (30·7% of the seventy-five patients) lost HBeAg reactivity in a mean follow-up period of 32·3 months, and thirteen patients (17·3% of the seventy-five patients) became seroconverted. Thus, the drug group showed significantly higher percentages of patients with disappearance of HBeAg and seroconversion, notwithstanding the shorter duration of the follow-up. Young males and females, females generally, or patients with high serum GPT levels were more likely to respond to the therapy. The serum GPT level tended to stabilize more inpatients receiving OK-432.
Double-Blind Comparison of Astemizole, Terfenadine and Placebo in Hay Fever with Special Regard to Onset of Action
Authors: Girard J P , Sommacal-Schopf D , Bigliardi P , Henauer S A 
Published: January 2017

In this double-blind study forty-seven patients with hay fever were treated for 8 days with either terfenadine 60 mg twice a day, astemizole 10 mg once a day or placebo. On the second day of treatment terfenadine was statistically significantly superior to astemizole and placebo according to the ratings of symptomatology, efficacy and individual symptoms. The median onset of symptom alleviation was 3 hours for terfenadine and 2 days for astemizole. On the eighth day both astemizole and terfenadine were statistically significantly more efficacious than placebo, but no significant differences were found between the two drugs. Both drugs were well tolerated.