bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Risk Keratoplasty Using Conditioned Media of Mesenchymal Stem Cells in an Experiment
Authors: Tereshchenko A. V. , Trifanenkova I. G. , Temnov A. A. , Bulatova Yu. D. , Demyanchenko S. K. , Sklifas А. N. , Shchatskikh A. V. , Shataev D. A. , Iolchiev R. B. 
Published: October 2024

Purpose: to evaluate in experiment the dynamics and intensity of vascular sprouting in the donor cornea during keratoplasty against the background of pre-existing neoangiogenesis when using a conditioned medium of mesenchymal stem cells.Materials and methods. The object of the study was 15 rabbits (10 recipient rabbits, 5 donor rabbits) of the gray Chinchilla breed weighing 2.5–3.2 kg. The experiments were carried out in two stages. At the first stage, 10 animals were simulated with a unilateral thermal burn of the peripheral zone of the cornea with limbal involvement. Penetrating keratoplasty was performed using standard technology on the 15th day of the experiment. At the second stage, the recipient rabbits were divided into experimental and control groups. 5 rabbits, 5 eyes, in the control group and 5 rabbits, 5 eyes, in the main group. In the main group, instillations of paracrine factors of mesenchymal stem cells were used as postoperative treatment from the 1st to the 30th knocks four times. In the control group, treatment was carried out by instillation of antibiotics (Oftaquix) and keratoprotectors (Korneregel) three times for 30 days. Research methods included biomicroscopy, photographic recording of the anterior segment of the eye, examination using a Pentacam AXL device, and histological examination. The observation periods were 1st, 3rd, 7th, 14th, 30th day.Results. The results of postoperative treatment at the second stage of the experiment, as well as the results of histology, showed a pronounced antiangiogenic effect of the conditioned medium of mesenchymal stem cells. This was confirmed by the absence of pronounced vascularization of the donor cornea, the attenuation of the inflammatory reaction and the formation of a scar on the 30th day of drug instillation. In the control group, graft disease developed from the seventh day.Conclusion. The results obtained during the work seem promising. The use of the conditioned medium of mesenchymal stem cells demonstrated a sufficiently pronounced effectiveness compared with standard drug therapy in the postoperative period after high-risk end-to-end keratoplasty in experimental animals performed on a model of post-burn corneal neovascularization.
Dysfunctional Changes in the Lens in Real Clinical Practice
Authors: Fursova A. Zh. , Loskutov I. A. , Borisov F. G. 
Published: October 2024

Introduction. Presbyopia is a global problem affecting more than 1.5 billion people worldwide. Projections indicate an increase in the average age of the population to 40 years by 2050, which is associated with an increase in the presbyopia incidence and corresponding economic losses. Despite the widespread prevalence of presbyopia, there are currently no effective methods for early prevention and restoration of dynamic accommodation and a standardized approach to assessing age-related changes in the lens that underlie presbyopia. The purpose: to study the effect of age-related changes in the lens on accommodation and to consider modern pharmacological approaches to the prevention and treatment of presbyopia.Methods. A multicenter prospective study was conducted, including analysis of visual acuity, the nearest point of clear vision and the volume of accommodation in individuals aged 40 to 55 years. Study participants were prescribed pyrenoxine (Catalin) as eye drops three times daily for 4 months. The study included 382 questionnaires collected from 29 ophthalmologists.Results. As a result of the study, the average distance to the nearest point of clear vision decreased slightly, but the reserve of accommodation remained at the same level. This indicates the absence of significant progression of age-related decrease in the reserve of accommodation as one of the manifestations of presbyopia and the possible effectiveness of pyrenoxine in preserving the elastic properties of the lens.Conclusion. The study confirmed the effectiveness of pyrenoxine in the prevention of presbyopia and the preservation of accommodative abilities in middle-aged people. The concept of Dysfunctional Lens Syndrome may be useful for clinical practice by providing opportunities for early diagnosis and treatment of presbyopia. Incorporating this concept into clinical guidelines may improve approaches to the treatment and prevention of age-related lens changes.
A ação integrativa como diferencial na formação do Técnico em Comunicação Visual - Projeto Revista
Authors: Da Silva Cíntia , Faria Pereira Heliza , Michael Silva Welisson 
Published: October 2024

Este artigo relata as contribuições de um projeto integrador multidisciplinar para a formação de alunos do Curso Técnico em Comunicação Visual Integrado ao Ensino Médio do IFSULDEMINAS, campus Passos. Apresentamos a experiência da utilização de um projeto editorial em formato de revista, executado no segundo semestre letivo do ano de 2019, com reflexões sobre os conceitos e as habilidades necessárias para o desenvolvimento de projetos de design editorial. Descrevemos, também, as etapas deste projeto integrador, no que diz respeito a sua criação, desenvolvimento e finalização, bem como o seu caráter formativo, por meio de práticas e situações-problema que simularam a realidade do mundo do trabalho e as peculiaridades profissionais da comunicação visual e do design gráfico. Este percurso resultou em produtos de alta qualidade editorial e estética. Além disso, a integração das disciplinas do curso Técnico em Comunicação Visual oportunizou aos estudantes a compreensão sobre uma formação interdisciplinar, corroborando para sua futura atuação como profissional da área.
ECONOMIC FEASIBILITY STUDY FOR THE IMPLEMENTATION OF A MICRO-INDUSTRY PRODUCING KOMBUCHA FLAVORED WITH PASSION FRUIT FROM THE CAATINGA.
Authors: Cerqueira Araujo Magalhães Caroline , Brandão Mafra de Carvalho Giovani , Ailton Conceição Bispo José 
Published: October 2024

Kombucha is a fermented beverage of Chinese origin produced from the infusion of black or green tea from the Camelia sinensis plant, sugar and a symbiotic culture known as SCOBY. After fermentation, the drink becomes rich in natural nutrients with functions that are beneficial to health such as organic acids, amino acids, vitamin C, polyphenols and antibiotic substances. The present work aims at carrying out a study of the economic feasibility of opening a micro-industry for the production of a black tea kombucha flavored with passion fruit from the caatinga. The caatinga passion fruit is a species native to the dry areas of northeastern Brazil. This fruit is rich in flavonoids, vitamin C and carotenoids, which have antimicrobial and antioxidant properties. For the development of the study, specifications of processes, equipment and analysis of financial and economic indicators were carried out. The evaluation of the investments was carried out using the internal rate of return (IRR), minimum attractiveness rate (TAM), net present value (NPV), simple payback and discounted payback methods. The initial investment for the production of 2,000 L of kombucha flavored with passion fruit from the caatinga was R$ 187,199.78. The economic indicators obtained resulted in NPV of R$ 253,154.68, IRR of 22%, TAM of 13.34% p.a. and simple payback of 3.9 years considering a useful life of 10 years. The positive IRR reflects that the enterprise is economically viable and profitable, making it possible to invest and generate income for cooperatives and family farmers.
PROPOSTA DE SINAIS-TERMO PARA PROMOÇÃO DA SAÚDE DA MULHER: GARANTIA PLENA DO DIREITO LINGUÍSTICO DA MULHER SURDA
Authors: Mendes Francisco Gildete S. Amorim 
Published: October 2024

O presente estudo se fundamenta nas discussões levantadas por diversos pesquisadores sobre a acessibilidade da saúde da mulher. São apresentadas as dificuldades de compreensão nos serviços de saúde – tanto para os profissionais do ramo quanto para os pacientes surdos, onde são trazidos relatos de insatisfação de ambas as partes com relação à comunicação. Desta forma, a presente pesquisa tem como objetivo apresentar os trabalhos já desenvolvidos no escopo da acessibilidade em saúde da mulher, especialmente com vistas a produzir o Glossário Bilíngue (Libras-Português) de Saúde da Mulher. Para isso, optou-se por uma busca preliminar de estudos que compõem a revisão de literatura, reunindo as perspectivas de pesquisadores e estudiosos da área. Os resultados se apresentam inicialmente em forma de tabela com sinais em Libras, a partir de vídeos disponíveis gratuitamente nas plataformas digitais. Foram elaboradas cinco fichas terminológicas que indicam uma parte dos 73 sinais-termo que estão sendo desenvolvidos. A elaboração dos materiais demonstrou atender uma carência que ainda se observa quanto à comunicação médico-paciente – que deve estar pautada nos direitos preconizados pelas legislações. Além disso, este estudo buscou incentivar a produção de novos materiais e conteúdos sobre o assunto em tela.
Exploring Impact and Variability of Research Productivity Among Academic Orthopaedic Leaders
Authors: Farooq Hassan , Gaetano Andrew , Shivdasani Krishin , Garbis Nickolas , Salazar Dane 
Published: October 2024

Introduction:
Assessing scholarly contributions in academic orthopaedic surgery remains challenging, despite the importance of publication productivity in evaluating academic leaders. The Hirsch (h)-index and its derivative, the m-index, offer objective measures to compare and evaluate publication productivity. The primary aims of this study were to compare h- and m-indices of department chairs and residency program directors of orthopaedic training programs in the United States and assess the association between h-index and program rank.

Methods:
A publicly available Doximity report was used to identify and rank orthopaedic surgery residency programs in the United States. Internet-based searches of institution-specific websites were performed to confirm current department chairs and residency program directors as of January 2024. H-index data were collected from a publicly available database known as Scopus. The m-index was calculated as the quotient of h-index and years in practice. Gender and years in practice were obtained through available biographies on institution-specific websites.

Results:
Department chairs had significantly higher h- and m-indices at both the career and 5-year time intervals compared with program directors. Upon subgroup analysis, department chairs and program directors at top-10 ranked programs had significantly higher h- and m-indices compared with the entire population of department chairs and program directors. Linear regression analyses demonstrated a direct linear association between department chair/program director h- and m-indices and program rank.

Conclusions:
Publication productivity was higher for department chairs than residency program directors. Orthopaedic leaders at top-10 institutions had higher publication productivity compared with those at institutions outside of the top 10, per Doximity rankings. Finally, there is substantial variation in publication productivity of orthopaedic surgeons in leadership roles at academic institutions in the United States.

Clinical Relevance:
This study highlights the publication productivity of orthopaedic surgery department chairs and residency program directors and describes the linear association between publication productivity of academic orthopaedic leaders and program rank. This information can be utilized by those interested in learning more about the publication productivity among academic orthopaedic surgeons across different institutions and can assist those who are involved in the hiring and promotion process at these academic institutions.
Direct observation of chiral edge current at zero magnetic field in a magnetic topological insulator
Authors: Wang Yihua , Zhu Jinjiang , Feng Yang , Zhou Xiaodong , Wang Yongchao , Lian Zichen , Lin Weiyan , He Qiushi , Lin Yishi , Wang Youfang , Yao Hongxu , Li Hao , Wu Yang , Wang Jing , Shen Jian , Zhang Jinsong , Wang Yayu , Wang Yongqian , Yang Shuai , Liu Chang 
Published: October 2024

Abstract

The chiral edge current is the boundary manifestation of the Chern number of a quantum anomalous Hall (QAH) insulator. Its direct observation is assumed to require well-quantized Hall conductance, and is so far lacking. The recently discovered van der Waals antiferromagnet MnBi2Te4 is theorized as a QAH in odd-layers but has shown Hall resistivity below the quantization value at zero magnetic field. Here, we perform scanning superconducting quantum interference device (sSQUID) microscopy on these seemingly failed QAH insulators to image their current distribution. When gated to the charge neutral point, our device exhibits edge current, which flows unidirectionally on the odd-layer boundary both with vacuum and with the even-layer. The chirality of such edge current reverses with the magnetization of the bulk. Surprisingly, we find the edge channels coexist with finite bulk conduction even though the bulk chemical potential is in the band gap, suggesting their robustness under significant edge-bulk scattering. Our result establishes the existence of chiral edge currents in a topological antiferromagnet and offers an alternative for identifying QAH states.
ROS-Responsive Nanoparticles with Antioxidative Effect for the treatment of Diabetic Retinopathy
Authors: Liu Yujia , Li Jinjin , Geng Kedui , Lu Xin , Shen Xiangchun , Guo Qianqian 
Published: October 2024

Abstract

Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes. While current clinical treatments focus on later stages of the disease, early intervention is crucial to impede its progression. Essential oils derived from Fructus Alpiniae zerumbet (EOFAZ) have shown promise in protecting against high glucose (HG)-induced Müller cell activation and the development of DR. In this study, we designed a reactive oxidative species (ROS)-responsive drug delivery system (NPSPHE@EOFAZ) to target early DR stages and combat oxidative stress. Our nanoparticles were engineered to detect and respond to elevated oxidative stress levels, effectively transporting EOFAZ into HG-exposed Müller cells. The NPSPHE@EOFAZ formulation exhibited significant efficacy in inhibiting abnormal cell growth, reducing oxidative stress, and alleviating inflammation in these cells. Moreover, in vivo experiments on diabetic mice with DR demonstrated that NPSPHE@EOFAZ mitigated early pathological changes by reducing oxidative stress and inflammation. Additionally, the NPSPHE@EOFAZ formulation minimized pathological damage in vital organs such as the heart, liver, spleen, lung, and kidney. These results highlight the potential of NPSPHE@EOFAZ as a promising antioxidant for early intervention in DR pathogenesis.
WITHDRAWN: Green Synthesis of Silver Nanoparticles and Effects on Winter Wheat and Barley Varieties
Authors: Minic Djordje D , Mladenovic-Markovic Katarina , Kesic Ana , Grujovic Mirjana , Markovic Stefan , Torbica Aleksandra , Djukic Nevena 
Published: October 2024

Abstract

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Reducing Acetochlor Toxicity through Subcritical Hydrolysis Technology: Investigating the Hydrolysis Mechanism
Authors: Pan Shuo , Zhou Huaiyu , Wu Shuang , Bai Jingru , Cui Da , Wang Qing , Xu Faxing , Wang Zhenye 
Published: October 2024

Abstract

The primary objective of this investigation was to address the toxicity associated with acetochlor (ACT) through subcritical hydrolysis treatment, assessing the efficacy of this approach in mitigating concerns related to acetochlor's toxicity. Gas chromatography-time-of-flight mass spectrometry (GC × GC-TOFMS), Fourier transform infrared spectrometry (FT-IR), and scanning electron microscopy (SEM) were employed to elucidate distribution patterns, variations in functional groups, and morphological features of the hydrolyzed derivatives of ACT. The hydrolytic transformation pathway and mechanisms of ACT product formation were determined by integrating findings from GC × GC-TOFMS analysis and characterization assessments. The subcritical hydrolysis experiments resulted in the identification of 39 hydrolytic by-products from ACT. The peak hydrolysis rate for ACT was observed at a hydrothermal temperature of 280 °C with a reaction duration of 60 minutes, leading to the complete hydrolysis of toxic by-products. In this study, subcritical hydrolysis technology demonstrated its effectiveness in mitigating the toxicity of ACT, achieving environmentally sustainable treatment, and aiding in the resolution of potential hazards posed by ACT to ecosystems and human health.
Meta-Inflammation and Endotoxemia in a Highly Translational Porcine Model of Diet-Induced Obesity
Authors: Henriksen Betina Lyngfeldt , Starbæk Sofie , Brogaard Louise , Jessen Eline , Jensen Tim , Goletz Steffen , Heegaard Peter M. H. , Skovgaard Kerstin 
Published: October 2024

Abstract

Meta-inflammation (chronic, low-grade systemic inflammation) is increasingly recognized as an essential link between obesity and the development of various non-communicable diseases. However, large animal models for studying obesity-related meta-inflammation are lacking. Minipigs have great potential as models for human diseases, warranting investigation of the performance of the Göttingen minipig as a model for obesity-associated meta-inflammation. Twenty-six pigs were fed a high fat, fructose, and cholesterol diet (HFFC) or a standard diet (SD) for 103 days, resulting in the HFFC group having a 45% higher body weight and 16% larger abdominal circumference by the end of the experiment. Meta-inflammation was shown in the HFFC group by elevated serum concentrations of the acute phase protein C-reactive protein for more than 60 days during development of obesity, accompanied by increased numbers of circulating neutrophils and monocytes. Additional obesity-related abnormalities included dyslipidemia, hepatosteatosis, and transcriptional changes to genes related to inflammation and metabolism in circulating leukocytes, liver, and visceral adipose tissue (VAT). Notably, transcription of genes related to lipid metabolism, namely ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1), was elevated in liver, VAT, and circulating leukocytes (ABCA1 only) in the HFFC group compared to the SD group. Development of obesity was accompanied by endotoxemia, evidenced by a 2.5-fold increase in serum lipopolysaccharide concentration in the HFFC group compared to the SD group, suggesting increased intestinal permeability. In conclusion, the described Göttingen minipig model convincingly links diet-induced obesity, meta-inflammation, and endotoxemia, achieved by short-duration HFFC dieting.
Glycerol and ascorbic acid-assisted synthesis of α-MoO3 nanoparticles as an efficient catalyst for biodiesel production
Authors: Sabzevar Arefe Moatamed , ghahramaninezhad Mahboube 
Published: October 2024

Abstract

This work exhibits a novel method for synthesizing α-MoO3 nanoparticles (NPs) using a convenient recipe that utilizes glycerol and ascorbic acid as polymerizing and green complexing agents. Different analytical techniques, including XRD, FT-IR, TGA, and scanning electron microscopy (SEM), were employed to identify the as-prepared α-MoO3 NPs, and it was used as a catalyst in biodiesel production. Moreover, the TPD experiment was performed to determine the catalyst's acidity strength. The α-MoO3 exhibited high efficiency in producing biodiesel from oleic acid and ethyl alcohol as an oil source and alcohol, respectively. The design of experiments and optimization process were also performed using response surface methodology (RSM) to attain the optimal condition. The influences of several parameters, such as catalyst dosage, reaction time, medium temperature, and alcohol to fatty acid (in molar ratio), were studied. The results demonstrate that at the optimal operating variables of 75°C, 50 min of reaction time, a 30:1 molar ratio of alcohol to oleic acid, and 0.007 g of catalyst, the yield of biodiesel production can approach 85%. Moreover, the obtained results indicated that the catalyst can be efficiently recovered and reused four times without significant loss in its activity.
Evolutionary relationships of the human Schistosoma haematobium clade and its intermediate hosts
Authors: Nelwan Martin 
Published: October 2024

Abstract

Purpose
In this research, I investigated the phylogenetic relationships of Schistosoma haematobium clade as well as the relationships of its intermediate hosts.
Results
Nucleotide BLAST revealed that Schistosoma haematobium DQ677664.1 shares 89.83% identity with S. guineensis DQ677663.1, 88.14% identity with S. bovis, and 84.1% identity with S. intercalatum. Schistosoma haematobium is derived from East Africa in Lake Victoria, i.e., Kenya, Tanzania, or Uganda. In this study, it was derived from Kenya. The African mainland S. haematonium and the Indian Ocean Islands S. haematobium have low genetic diversity. Schistosoma haematobium can infect B. truncatus, B. globosus, B. forskalii, B. nasutus, and B. productus. Schistosoma bovis infects B. tropicus. Bulinus wrighti is the same species as B. nasutus in the Indian Ocean Islands. Bulinus wrighti should be named B. nasutus wrighti.
Conclusions
Schistosoma haematobium has low genetic diversity. Schistosoma haematobium came from Kenya. Bulinus wrighti belongs to B. nasutus. It should be named B. nasutus wrighti.
WITHDRAWN: Study on accumulation deformation characteristics of silty clay based on dynamic triaxial tests
Authors: Chen Guoqiang , Yang Wenjie , Pan Yuangui , Zheng Yuchao , Zhang Huijian , Shao Shiyou , Lu Feng , Yang Chuhan , Guo Leilei 
Published: October 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
WITHDRAWN: An experimental study on the effects of moisture content and confining pressure on the damping ratio of silty clay
Authors: Chen Jianshen , Chen Guoqiang , Pan Yuangui , Zheng Yuchao , Zhang Huijian , Shao Shiyou , Lu Feng 
Published: October 2024

Abstract

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.