bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Elusive 2H‐1,2‐Oxasiletes Through Reactions of an Isolable Dialkylsilylene with Diazocarbonyl Compounds.
Authors: Dong Zhaowen , Xiao Xu‐Qiong , Li Zhifang , Lu Qiong , Lai Guoqiao , Kira Mitsuo 
Published: December 2015

AbstractNovel 2H‐1,2‐oxasiletes (III) are obtained in high yields by reaction of diazocarbonyl compounds (I) with dialkylsilylene (II), whilst diazoketone (IV) leads to spirocyclic adduct (V) without releasing dinitrogen.
ChemInform Abstract: Chloroform‐Based Atherton—Todd‐Type Reactions of Alcohols and Thiols with Secondary Phosphine Oxides Generating Phosphinothioates and Phosphinates.
Authors: Li Shan , Chen Tieqiao , Saga Yuta , Han Li‐Biao 
Published: December 2015

AbstractChloroform replaces the highly toxic CCl4 as halogenating reagent and solvent in Atherton—Todd‐type reactions of alcohols and thiols with secondary phosphine oxides.
ChemInform Abstract: Synthesis of a New Class of Iminosugars Based on Constrained Azaspirocyclic Scaffolds by Way of Catalytic C—H Amination.
Authors: Nocquet Pierre‐Antoine , Hensienne Raphael , Wencel‐Delord Joanna , Wimmer Eric , Hazelard Damien , Compain Philippe 
Published: December 2015

AbstractIminosugars (VI) and (VII) are synthesized from substrate (I) via Rh‐catalyzed intramolecular amination followed by N‐allylation, metathesis reaction, and either hydrogenation/deprotection or dihydroxylation/deprotection sequences.
ChemInform Abstract: Regioselective and 1,2‐cis‐α‐Stereoselective Glycosylation Utilizing Glycosyl‐Acceptor‐Derived Boronic Ester Catalyst.
Authors: Nakagawa Akira , Tanaka Masamichi , Hanamura Shun , Takahashi Daisuke , Toshima Kazunobu 
Published: December 2015

AbstractVarious 1α,2α‐anhydro glycosyl donors such as (I) react with diol glycosyl acceptors in the presence of a boron catalyst, derived in situ from the acceptor component and the boronic acid in the reaction medium.
ChemInform Abstract: Three New Alkaloids from Hippophae rhamnoides Linn. subsp. sinensis Rousi.
Authors: OuYang Jian , Zhou Wen‐Na , Li Gang , Wang Xiao‐Yan , Ding Chen‐Xu , Suo You‐Rui , Wang Hong‐Lun 
Published: December 2015

AbstractThe new organic amide alkaloids (I) and (II) are isolated along with a rare pyridoindole alkaloid, hippophamide (III), from the seed residue of Hippophae rhamnoides Linn.
ChemInform Abstract: Pericoannosin A, a Polyketide Synthase—Nonribosomal Peptide Synthetase Hybrid Metabolite with New Carbon Skeleton from the Endophytic Fungus Periconia sp.
Authors: Zhang Dewu , Tao Xiaoyu , Chen Ridao , Liu Jimei , Li Li , Fang Xiaomei , Yu Liyan , Dai Jungui 
Published: December 2015

AbstractFour new compounds, pericoannosin A (I) having an unusual carbon skeleton and periconiasins D‐F (II), (III), and (IV) are isolated.
Was ist Licht?
Authors: Wöhrle Dieter 
Published: December 2015

Abstract2015 begehen die Vereinten Nationen das “Internationale Jahr des Lichts und der lichtbasierten Technologien”. Licht basiert auf Photonen. In diesem ersten Teil wird der gegenwärtige Kenntnisstand über Photonen, die Energiequanten der elektromagnetischen Strahlung sind und sowohl Wellen‐ als auch Teilchencharakter aufweisen, aufgearbeitet. Der Weg der Photonen von der Sonne als natürliche Strahlungsquelle bis zur Erdoberfläche wird behandelt. Aber auch künstliche Strahlungsquellen, die für unsere visuelle Wahrnehmung wichtig sind, liefern Photonen wie z.B. die ineffiziente Glühlampe und die Energie‐einsparende anorganische und organische Leuchtdiode. Laser als künstliche Strahlungsquelle mit technischer Bedeutung werden auch angesprochen. Der Teil 2 wird sich schwerpunktmäßig mit Anwendungen in der Photokatalyse, der Photochemie und den anorganischen und organischen photovoltaischen Solarzellen befassen.
Defective Single‐Walled Aluminosilicate Nanotubes: Structural Stability and Mechanical Properties
Authors: Liou Kai‐Hsin , Kang Dun‐Yen 
Published: December 2015

AbstractSingle‐walled aluminosilicate nanotubes (AlSiNTs) are expected to possess mechanical strength comparable to that of single‐walled carbon nanotubes (SWCNTs). Most existing theoretical studies on the mechanical properties of AlSiNTs are based on defect‐free models, despite the fact that experimental results have revealed a variety of defects in AlSiNTs. Herein we developed a method for the modeling of defective AlSiNTs to enable the quantitative investigation of relationships among defect structures, structural stability, and mechanical properties of AlSiNTs. The defect structures dealt with in the proposed models are based on experimental findings. Our assessment of the stability and mechanical strength of nanotubes is based on multiscale computational tools, including density functional theory, molecular modeling, and nanoscale continuum modeling. Our study also identified the defect structure with the most pronounced impact on the stability and mechanical properties of AlSiNTs.
Research Progress on the Indirect Hydrogenation of Carbon Dioxide to Methanol
Authors: Du Xian‐Long , Jiang Zheng , Su Dang Sheng , Wang Jian‐Qiang 
Published: December 2015

AbstractMethanol is a sustainable source of liquid fuels and one of the most useful organic chemicals. To date, most of the work in this area has focused on the direct hydrogenation of CO2 to methanol. However, this process requires high operating temperatures (200–250 °C), which limits the theoretical yield of methanol. Thus, it is desirable to find a new strategy for the efficient conversion of CO2 to methanol at relatively low reaction temperatures. This Minireview seeks to outline the recent advances on the indirect hydrogenation of CO2 to methanol. Much emphasis is placed on discussing specific systems, including hydrogenation of CO2 derivatives (organic carbonates, carbamates, formates, cyclic carbonates, etc.) and cascade reactions, with the aim of critically highlighting both the achievements and remaining challenges associated with this field.
The appropriate dose of angiotensin‐converting‐enzyme inhibitors or angiotensin receptor blockers in patients with dilated cardiomyopathy. The higher, the better?
Authors: Ishida Junichi , Konishi Masaaki , von Haehling Stephan 
Published: December 2015

AbstractHeart failure is a major public issue, and dilated cardiomyopathy (DCM) is one of the common etiologies of heart failure. DCM is generally progressive, and some patients with DCM need heart transplant despite optimal medical and mechanical therapy. Current guidelines recommend inhibitors of renin–angiotensin–aldosterone system, namely angiotensin‐converting‐enzyme (ACE) inhibitor, angiotensin receptor blocker (ARB), and mineralocorticoid receptor antagonist as well as beta‐blockers for the medical treatment of heart failure with reduced ejection fraction, including DCM. Furthermore, because they have beneficial effects on the outcome of heart failure in a dose‐related fashion, they should be titrated to the target dose. In clinical practice, the underuse and under‐dose of these agents matter; however, the efficacy and safety of supramaximal dose of ACE inhibitor or ARB have never been investigated in the patients with DCM. In this issue of ESC Heart Failure, it is demonstrated that benazepril or valsartan at supramaximal dose improved left ventricular function and reduced cardiovascular events compared with each drug at low dose, respectively. In this editorial, the current evidence concerning the use of ACE inhibitor or ARB in patients with HF and future prospective will be discussed.
EPR as a Tool for Study of Isolated and Coupled Paramagnetic Centers in Coordination Compounds and Macromolecules of Biological Interest
Authors: Rizzi Alberto C. , Neuman Nicolás I. , González Pablo J. , Brondino Carlos D. 
Published: December 2015

AbstractContinuous Wave Electron Paramagnetic Resonance (CW EPR) is an essential spectroscopic tool for study of systems containing unpaired electrons. The potential capability of the technique has extended its use beyond being solely by experts, and today it is widely used by non‐specialists. In this microreview we present selected examples together with basic theoretical aspects necessary for understanding of the EPR properties of isolated paramagnetic centers and assemblies of them that may be coupled by very weak isotropic exchange interactions (<0.1 cm–1) when linked by diamagnetic extended chemical pathways. The goal of the paper is to show in a unified way the information that CW EPR can provide for understanding of the electronic structures and magnetic properties of distinct types of paramagnetic transition‐metal‐ion‐containing systems of biological relevance, such as low‐molecular‐weight inorganic complexes and metalloproteins.
Self‐Assembly of Triphenylboroxine and the Phenylboronic Ester of Pentaerythritol with Piperazine, trans‐1,4‐Diaminocyclohexane, and 4‐Aminopyridine
Authors: Cruz‐Huerta Jorge , Campillo‐Alvarado Gonzalo , Höpfl Herbert , Rodríguez‐Cuamatzi Patricia , Reyes‐Márquez Viviana , Guerrero‐Álvarez Jorge , Salazar‐Mendoza Domingo , Farfán‐García Norberto 
Published: December 2015

AbstractThe dinuclear phenylboronic ester derived from pentaerythritol and trinuclear triphenylboroxine were combined with three diamine tectons, that is, 1,4‐diazacyclohexane (pz), trans‐1,4‐diaminocyclohexane (1,4‐chda), and 4‐aminopyridine (4‐apy), to generate supramolecular N→B bound assemblies and to enhance the knowledge concerning the factors governing the formation of such aggregates. From these reactions, three novel complexes of composition {(PhBO)3(pz)}n·nDMF (2), {[(PhBO)3]2(1,4‐chda)}·1,4‐chda (3), and {[(PhBO2)2(C5H8)][4‐apy]2}·CHCl3·1.25H2O (4) were achieved and characterized by elemental analysis, IR and NMR spectroscopy, and single‐crystal X‐ray diffraction analysis. Structural characterization in the solid state revealed that all three products exhibit N→B bonds but have different compositions concerning the B and N tectons to give a 1:1 adduct for 2, a 2:1 adduct for 3, and a 1:2 adduct for 4. In the solid state, compound 2 comprises a 1D coordination polymer, whereas compounds 3 and 4 have discrete molecular structures. Owing to the presence of N–H hydrogen‐bonding sites, in all cases overall 2D or 3D hydrogen‐bonding networks are formed. In solution, the N→B aggregates are mostly dissociated at room temperature, as shown by 11B NMR spectroscopy.
Towards Isocoumarin‐Fused Enediyne Systems through the Electrophilic Cyclization of Methyl o‐(Buta‐1,3‐diynyl)benzoates
Authors: Danilkina Natalia A. , Gurskaya Larisa Y. , Vasilyev Aleksander V. , Balova Irina A. 
Published: December 2015

AbstractThe synthesis of enediynes fused to an isocoumarin core was achieved through the electrophilic cyclization of o‐(buta‐1,3‐diynyl)benzoates as a key step, followed by the Sonogashira coupling of the resulting 3‐ethynyl‐4‐iodoisocoumarins with acetylenes. This approach allowed different substituents to be introduced to both ethynyl moieties with complete regiocontrol. The ability of the isocoumarin‐fused enediynes to undergo Bergman cyclization was studied by differential scanning calorimetry.
Fine‐Tuning the Balance between Peptide Thioester Cyclization and Racemization
Authors: Popovic Stanimir , Wijsman Linda , Landman Iris R. , Sangster Maaike F. , Pastoors Dorien , Veldhorst Berend B. , Hiemstra Henk , van Maarseveen Jan H. 
Published: December 2015

AbstractRing‐closure towards seven‐membered bislactams containing an α‐amino acid and β‐alanine is problematic. Such difficult lactamizations are accompanied by side‐reactions such as hydrolysis, oligomerization and racemization. By starting from linear peptide 4‐methoxythiophenol esters, dilution to 1 mM in combination with phosphate buffer (pH 6.8) intermolecular reactions and racemization could be largely suppressed. Thioesters with the chiral residue at the C‐terminus gave the bislactams in yields up to 60 % and enantiomeric excess up to 99 %. Enantiopure bislactams were obtained exclusively from the reversed sequence bearing β‐alanine at the C‐terminus.
Determination of some β‐Blockers by Electrochemical Detection on Polycrstalline Gold Electrode after Solid Phase Extraction (SPE)
Authors: Casella Innocenzo G. , Bonito Rosa , Contursi Michela 
Published: December 2015

AbstractThe electroanalytical characterization and determination of three selected β‐blocker agents, namely propranolol, atenolol and nadolol using cyclic voltammetry and differential pulse voltammetry (DPV) in phosphate buffer solution (pH 2.5) plus 22 % acetonitrile (ACN), was described. The analytes were characterized through their electrooxidation processes on polycrystalline gold electrodes. The analytical determination of the selected molecules was performed using the differential pulse voltammetry (DPV) at pH 2.5. Under DPV conditions, the detection limits (LODs) ranged between 5 μM and 20 μM for propranolol and atenolol, respectively. For all investigated molecules, two well‐defined ranges of linearity Ip vs analyte concentration have been identified which correspond to specific calibration parameters. Calibration graphs (Ip vs concentration) considered in the first interval of linearity, shown correlation coefficients >0.99. A solid phase extraction (SPE) procedure using a polymeric mixed‐mode cationic sorbent (Strata‐X‐C), was studied and optimized. The proposed DPV‐SPE method was successfully applied for the determination of propranolol in several pharmaceutical formulations and urine sample, with results in close agreement with those obtained using traditional liquid chromatography technique coupled with spectrophotometric detection.
Prostate Cancer Biomarker Detection with Carbon Nanotubes Modified Screen Printed Electrodes
Authors: Nur Topkaya Seda , Ozkan‐Ariksoysal Dilsat 
Published: December 2015

AbstractDNA hypermethylation is an epigenetic alteration and a promising biomarker for early prostate cancer detection. Simple, sensitive, easy to handle and rapid detection methodologies are imperative for point of care diagnostics especially for cancer. Herein, we describe for the first time a regenerable and compatible electrochemical biosensor for detection of Glutathione S‐Transferase P‐1 (GSTP‐1) gene hypermethylation related to prostate cancer via DNA hybridization onto the disposable Carbon and Multi Walled Carbon Nanotubes (MWCNT) Screen Printed Electrodes (SPEs). In the study, capture probes were adsorbed onto the SPEs by simple passive adsorption and then hybridization was achieved by sending the complementary target onto the probe‐modified electrodes. The selectivity of the biosensor was proved by control studies. Differential Pulse Voltammetry (DPV) technique was used to detect hybridization via guanine oxidation signals changes. The total time of the optimized method was nearly 1h, measurements took for less than 1 min, and the biosensor response was stable up to 40 days of storage period at 4 °C. The main advantages of the biosensor are very low detection limit (picomolar range) and capability of reusing the biosensor for at least 3 times after very simple regeneration process that is a unique property to reduce the cost of the assay. In addition, this is the first study that demonstrates the detection of GSTP‐1 hypermethylation electrochemically by using SPEs in order to create point of care diagnostics. The optimum parameters for the biosensor, as well as its future prospects to enhance the performance of DNA biosensors were also presented.
The role of coal seam properties on coupled processes during CO2sequestration: A parametric study
Authors: Masoudian Mohsen S. , Airey David W. , El‐Zein Abbas 
Published: December 2015

AbstractIt has been proposed that a considerable amount of CO2can be safely sequestered from the atmosphere in geological formations such as coalbeds. In spite of promising evidence of the economic and technical viability of CO2sequestration in coal seams, many of its hydro‐geomechanical aspects are not fully understood. This paper presents a coupled hydro‐mechanical model that is used to assess the reservoir performance of a coalbed and the induced surface and subsurface deformations. A series of numerical simulations has been performed to study the effects of different parameters on the reservoir and geomechanical behaviors associated with CO2injection. A single‐phase dual‐porosity model is coupled to a one‐dimensional poroelastic model and an analytical model for the ground surface movements. Through these simulations, the role of three sets of parameters at different scales is investigated: fracture characteristics, matrix characteristics, and geomechanical/geometrical characteristics. The comparative impacts of these parameters on reservoir permeability, volume of the stored CO2, and deformations of the coalbed and the ground surface, are quantitatively assessed, in order to identify the most important parameters influencing the hydro‐mechanical response of the ground.
Early detection of Alzheimer's disease using MRI hippocampal texture
Authors: Sørensen Lauge , Igel Christian , Liv Hansen Naja , Osler Merete , Lauritzen Martin , Rostrup Egill , Nielsen Mads ,   for the Alzheimer's Disease Neuroimaging Initiative and the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing
Published: December 2015

AbstractCognitive impairment in patients with Alzheimer's disease (AD) is associated with reduction in hippocampal volume in magnetic resonance imaging (MRI). However, it is unknown whether hippocampal texture changes in persons with mild cognitive impairment (MCI) that does not have a change in hippocampal volume. We tested the hypothesis that hippocampal texture has association to early cognitive loss beyond that of volumetric changes. The texture marker was trained and evaluated using T1‐weighted MRI scans from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, and subsequently applied to score independent data sets from the Australian Imaging, Biomarker & Lifestyle Flagship Study of Ageing (AIBL) and the Metropolit 1953 Danish Male Birth Cohort (Metropolit). Hippocampal texture was superior to volume reduction as predictor of MCI‐to‐AD conversion in ADNI (area under the receiver operating characteristic curve [AUC] 0.74 vs 0.67; DeLong test, p = 0.005), and provided even better prognostic results in AIBL (AUC 0.83). Hippocampal texture, but not volume, correlated with Addenbrooke's cognitive examination score (Pearson correlation, r = −0.25, p < 0.001) in the Metropolit cohort. The hippocampal texture marker correlated with hippocampal glucose metabolism as indicated by fluorodeoxyglucose‐positron emission tomography (Pearson correlation, r = −0.57, p < 0.001). Texture statistics remained significant after adjustment for volume in all cases, and the combination of texture and volume did not improve diagnostic or prognostic AUCs significantly. Our study highlights the presence of hippocampal texture abnormalities in MCI, and the possibility that texture may serve as a prognostic neuroimaging biomarker of early cognitive impairment. Hum Brain Mapp 37:1148–1161, 2016. © 2015 Wiley Periodicals, Inc.
Improving the rate of negative margins after surgery for oral cavity squamous cell carcinoma: A prospective randomized controlled study
Authors: Amit Moran , Na'ara Shorook , Leider‐Trejo Leonor , Akrish Sharon , Cohen Jacob T. , Billan Salem , Gil Ziv 
Published: December 2015

AbstractBackgroundA positive margin is among the most significant factors that affects the outcome in head and neck squamous cell carcinoma (SCC). The purpose of this study was to compare the negative margin rates between 2 methods of intraoperative margin assessment in patients with oral cavity SCC.MethodsA prospective, randomized controlled trial comparing 2 methods of intraoperative margin assessment: specimen‐driven margins and patient‐driven margins.ResultsThe final analysis included 71 patients, 20 (29%) in the patient‐driven margin arm. Frozen section analysis revealed positive/close surgical margins that led to an extension of the surgical resection in 22 of 51 patients (43%) in the specimen‐driven margin arm, and 2 of 20 patients (10%) in the patient‐driven margin arm (p = .01). After final pathological analysis, the wide negative margin rate was 84% in the specimen‐driven margin arm, compared to 55% in the patient‐driven margin arm (p = .02). Extension of the surgical resection prevented escalation of adjuvant treatment in 19 patients (38%) in the specimen‐driven margin arm and 10% in the patient‐driven margin arm.ConclusionSpecimen derived margin assessment led to significant improvement in the rate of negative margins. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1803–E1809, 2016
Salicylic acid‐based poly(anhydride‐ester) nerve guidance conduits: Impact of localized drug release on nerve regeneration
Authors: Lee Yong S. , Griffin Jeremy , Masand Shirley N. , Shreiber David I. , Uhrich Kathryn E. 
Published: December 2015

AbstractNerve guidance conduits (NGCs) can serve as physical scaffolds aligning and supporting regenerating cells while preventing scar tissue formation that often interferes with the regeneration process. Numerous studies have focused on functionalizing NGCs with neurotrophic factors, for example, to support nerve regeneration over longer gaps, but few directly incorporate therapeutic agents. Herein, we fabricated NGCs from a polyanhydride comprised of salicylic acid (SA), a nonsteroidal anti‐inflammatory drug, then performed in vitro and in vivo assays. In vitro studies included cytotoxicity, anti‐inflammatory response, and NGC porosity measurements. To prepare for implantation, type I collagen hydrogels were used as NGC luminal fillers to further enhance the axonal regeneration process. For the in vivo studies, SA‐NGCs were implanted in femoral nerves of mice for 16 weeks and evaluated for functional recovery. The SA‐based NGCs functioned as both a drug delivery vehicle capable of reducing inflammation and scar tissue formation because of SA release as well as a tissue scaffold that promotes peripheral nerve regeneration and functional recovery. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 975–982, 2016.
Safety of intradiscal injection and biocompatibility of polyester amide microspheres in a canine model predisposed to intervertebral disc degeneration
Authors: Willems Nicole , Mihov George , Grinwis Guy C.M. , van Dijk Maarten , Schumann Detlef , Bos Clemens , Strijkers Gustav J. , Dhert Wouter J.A. , Meij Björn P. , Creemers Laura B. , Tryfonidou Marianna A. 
Published: December 2015

AbstractRepair of degenerated intervertebral discs (IVD) might be established via intradiscal delivery of biologic therapies. Polyester amide polymers (PEA) were evaluated for in vitro cytotoxicity and in vivo biocompatibility, and thereafter intradiscal application of PEA microspheres (PEAMs) in a canine model predisposed to IVD degeneration at long‐term (6 months) follow‐up. PEA extracts did not induce cytotoxicity in mouse fibroblast cells (microscopy and XTT assay), while a slight foreign body reaction was demonstrated by histopathology after intramuscular implantation in rabbits. Intradiscal injection of a volume of 40 µL through 26 and 27G needles induced no degenerative changes in acanine model susceptible to IVD disease. Although sham‐injected IVDs showed increased CAV1 expression compared with noninjected IVDs, which may indicate increased cell senescence, these findings were not supported by immunohistochemistry, biomolecular analysis of genes related to apoptosis, biochemical and histopathological results. PEAM‐injected IVDs showed significantly higher BAX/BCL2 ratio vs sham‐injected IVDs suggestive of an anti‐apoptotic effect of the PEAMs. These findings were not supported by other analyses (clinical signs, disc height index, T2 values, biomolecular and biochemical analyses, and IVD histopathology). PEAs showed a good cytocompatibility and biocompatibility. PEAMs are considered safe sustained release systems for intradiscal delivery of biological treatments. © 2015 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 707–714, 2017.