bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stirring the Pot: Supporting and Challenging General Education Science, Technology, Engineering, and Mathematics Faculty to Change Teaching and Assessment Practice
Authors: Stieha Vicki , Shadle Susan E. , Paterson Sharon 
Published: March 2017

Abstract
Evidence-based instructional practices (ebips) have been associated with positive student outcomes; however, institutions struggle to catalyze widespread adoption of these practices in general education science, technology, engineering, and mathematics (stem) courses. Further, linking ebips with integrated learning assessment is rarely discussed in the literature, even though principles of continuous course design for quality higher education assume the connection of learning outcomes, teaching practices, and assessment. This qualitative action research study documents faculty attempting to utilize ebips and authentic assessment when they were provided support and accountability over multiple semesters. It documents participants' current practices and encourage shifts in both teaching and assessment practices targeting greater student success in stem general education courses. Narrative data drawn from interviews and written reflection describe the impact of structured faculty observation and cross-disciplinary conversation on participants' pedagogical and assessment choices. The faculty participants' voices vividly illustrate our findings: incentives, reflection, mentorship, and collaboration over multiple semesters support changing pedagogical practices and integrating outcomes assessment. While stem-based, the study findings are applicable across the general education curriculum.
Cultura, open source y nuevos modos de educar(se)
Authors: Vega Ricardo 
Published: March 2017

Este texto busca introducir, abusando del breve espacio comprometido,
algunas ideas y proyectos que ejempliflcan el valor de la cooperación y el
open source en los cambios de las practicas creativas y educacionales.
Vivimos en una sociedad basada en la idea de comperencia, donde se dan
incentivos a las personas para seguir sus intereses individuales. Pensar y
actuar de manera individual y aislada seria ideal si viviéramos solos en una
isla desierra, pero vivimos en sociedades complejas, en constante interacción
entre nosotros, de uno a uno, de uno a muchos, o de muchos a
muchos. Esta noción tiene diversos orígenes, pero es principalmente el
economista escocés Adam Smith quien planteó la idea sobre la maximización
del beneficio individual, lo que da pie a la manera en que vemos
y conformamos una sociedad. Smith plamea que apelando al egoismo de
los individuos para perseguir sus propios intereses se lograría el bienestar
general de la sociedad. Asi, la idea de individuos compitiendo constantemente
se instala en los hábitos sociales de producción como algo
absolutamente natural.
Crystal Diagnostics Xpress S Kit for the Rapid Detection of Salmonellaspp. in Selected Food Matrixes
Authors: Bullard Brian , Stumpf Curtis H , Zhao Weidong , Kuzenko Stephanie , Niehaus Gary D 
Published: March 2017

Abstract
The Crystal Diagnostics (CDx) Xpress S Kit is a rapid-screening assay for Salmonella spp. in whole raw tomatoes, whole chicken carcasses, raw ground beef, raw beef trim, and whole liquid pasteurized eggs with citric acid when present at levels of 1 CFU/portion size. The Xpress S system comprises an automatic CDx Xpress Reader and a single-use CDx BioCassette that incorporates antibody-coupled microspheres and liquid crystal for the selective identification of the intended microbe. In internal evaluations, the CDx Xpress S Kit detected all 142 Salmonella strains tested, including non-enterica subspecies, and excluded all non-Salmonella species assayed. Method-developer studies, as well as a third-party evaluation, demonstrated that 15 h single-stage enrichment permits rapid detection equivalent to the U.S. Department of Agriculture and U.S. Food and Drug Administration reference methods. The results demonstrate that the CDx Xpress S Kit is one of the fastest, most sensitive, and most accurate methods for detecting Salmonella in food matrixes.
Editorial
Authors: Rabinovich Elaine Pedreira , Gallo Paulo Rogério 
Published: March 2017

A RBCDH está no seu 17º ano, iniciando o seu caminho para a maioridade. Foi concebida, em1991, por um grupo originário de um relacionamento entre professores do Departamento de Saúde Materno-Infantil da Faculdade de Saúde Pública da USP e profissionais externos à Universidade. O objetivo do grupo, iniciado em 1987 – o CDH – era unir teoria e prática, donde a revista nasceu deste propósito e a ele se manteve atrelada. A partir de 2005, a revista passou de duas a três edições anuais, e, atualmente, assume a trimestralidade.
Plantar Static Pressure Distribution in Normal Feet Using Cotton Socks with Different Structures
Authors: Soltanzadeh Zeynab , Najar Saeed Shaikhzadeh , Haghpanahi Mohammad , Mohajeri-Tehrani Mohammd Reza 
Published: March 2017

Background:The major goal of investigating plantar pressure in patients with pain or those at risk for skin injury is to reduce pressure under prominent metatarsal heads, especially the first and second metatarsals. In research, the insole is used to reduce plantar pressure by increasing the contact area in the midfoot region, which, in turn, induces an uncomfortable feeling near the arch during walking. It is deduced that sock structure can redistribute plantar pressure distribution.Methods:Seven sock types with seven structures (plain, single cross tuck, mock rib inlay, cross miss, mock rib, double cross tuck, and double cross miss) for the sole area were produced. A plantar pressure measurement device was used to measure plantar static pressure in ten participants. The barefoot plantar pressure distribution was compared with the plantar pressure distribution with socks.Results:In the seven sock samples, the mean plantar pressure of the cross miss and mock rib structures at high plantar pressure zones (toe and first through fourth metatarsal bone regions) were decreased, and, as a result, the pressure shifted to relatively low pressure zones (fifth metatarsal bone and midfoot regions).Conclusions:These results indicate that wearing socks with cross miss and mock rib structures will reduce mean plantar pressure values compared with the barefoot condition in high plantar pressure zones. In general, the results suggest that mean plantar pressure is redistributed from high to low plantar pressure zones.
Relationship Between Weightbearing Ankle Dorsiflexion Passive Range of Motion and Ankle Kinematics During Gait
Authors: Kang Min-Hyeok , Oh Jae-Seop 
Published: March 2017

Background:Measurement of weightbearing ankle dorsiflexion (DF) passive range of motion (PROM) has been suggested as a way to estimate ankle kinematics during gait; however, no previous study has demonstrated the relationship between ankle DF during gait and ankle DF PROM with knee extension. We examine the relationship between maximum ankle DF during gait and nonweightbearing and weightbearing ankle DF PROM with knee extension.Methods:Forty physically active individuals (mean ± SD age, 21.63 ± 1.73 years) participated in this study. Ankle DF PROM with knee extension was measured in the nonweightbearing and weightbearing conditions; maximum ankle DF during gait was assessed using a three-dimensional motion analysis system. The relationship between each variable was calculated using the Pearson product moment correlation coefficient, and the difference in ankle DF PROM between the nonweightbearing and weightbearing conditions was analyzed using a paired t test.Results:The weightbearing measurement (r = 0.521; P &lt; .001) for ankle DF PROM showed a greater correlation with maximum ankle DF during gait than did the nonweightbearing measurement (r = 0.245; P = .029). Ankle DF PROM was significantly greater in the weightbearing than in the nonweightbearing condition (P &lt; .001) despite a significant correlation between the two measurements (r = 0.402; P &lt; .001).Conclusions:These findings indicate that nonweightbearing and weightbearing measurements of ankle DF PROM with knee extension should not be used interchangeably and that weightbearing ankle DF PROM with the knee extended is more appropriate for estimating ankle DF during gait.
Mid-Term Results of Minimally Invasive Plate Osteosynthesis and Circular External Fixation in the Treatment of Complex Distal Tibia Fractures
Authors: Imren Yunus , Desteli Engin Eren , Erdil Mehmet , Ceylan Hasan Hüseyin , Tuncay Ibrahim , Sen Cengiz 
Published: March 2017

Background:
The treatment of pilon tibia fractures is challenging. Anatomical reduction of the joint surface is essential. Excessive soft-tissue dissection may interfere with the blood supply and can result in nonunion. We sought to compare the outcomes of distal tibia fractures treated with medial locking plates versus circular external fixators.

Methods:
We retrospectively evaluated 41 consecutive patients with closed pilon tibia fractures treated with either minimally invasive locking plate osteosynthesis (n = 21) or external fixation (EF) (n = 20). According to the Ruedi and Allgower classification, 23 fractures were type B and 18 were type C. Soft-tissue injury was evaluated according to the Oestern and Tscherne classification. Time to fracture union, complications, and functional outcomes were assessed annually for 3 years with the American Orthopaedic Foot and Ankle Society (AOFAS) ankle score.

Results:
Mean ± SD values in the plate group were as follows: age, 42.4 ± 14 years; union time, 19.4 ± 2.89 weeks (range, 12–26 weeks); and AOFAS ankle scores, 86.4 ± 2.06, 79.5 ± 1.03, and 77.9 ± 0.80 at 1, 2, and 3 years, respectively. Four patients in the plate group needed secondary bone grafting during follow-up. In the EF group (mean ± SD age, 40.7 ± 12.3 years), all of the patients achieved union without secondary bone grafting at a mean ± SD of 22.1 ± 1.7 weeks (range, 18–24 weeks). In the EF group, mean ± SD AOFAS ankle scores were 86.6 ± 1.69, 82.1 ± 0.77, and 79.7 ± 1.06 at 1, 2, and 3 years, respectively. There were no major complications. However, there were soft-tissue infections over the medial malleolus in five patients in the plate group and grade 1-2 pin-tract infections in 13 patients and grade 3 pin-tract infections in one patient in the EF group. Post-traumatic arthritis was detected in eight plate group patients and seven EF group patients.

Conclusions:
Minimally invasive plating and circular EF methods have favorable union rates with fewer complications.
The Effects of Talus Control Foot Orthoses in Children with Flexible Flatfoot
Authors: Ahn So Young , Bok Soo Kyung , Kim Bong Ok , Park In Sik 
Published: March 2017

Background:A talus control foot orthosis (TCFO) combines an inverted rigid foot orthosis (RFO) with a broad upright portion that rises well above the navicular to cover and protect the talonavicular joint. We sought to identify the therapeutic effect of TCFOs in children with flexible flatfoot.Methods:Flexible flatfoot was diagnosed in 40 children when either of the feet had greater than 4° valgus of resting calcaneal stance position (RCSP) angle and one of the radiographic indicators was greater than 30° in anteroposterior talocalcaneal angles, 45° in lateral talocalcaneal angles, and 4° in lateral talometatarsal angles and less than 10° of calcaneal pitch in barefoot radiographs. Of 40 children with flexible flatfoot, 20 were fitted with a pair of RFOs and 20 with TCFOs, randomly. Follow-up clinical and radiographic measurements were completed 12 months later.Results:All of the radiographic indicators changed toward the corrective direction in both groups. There were significant improvements in calcaneal pitch and RCSP in both groups (P &lt; .05). In the TCFO group, the anteroposterior talocalcaneal angle and the RCSP showed statistically significant improvement compared with the RFO group.Conclusions:In this study, the TCFO was more effective than the RFO at treating children with flexible flatfoot.
Hard time to be parents? Sea urchin fishery shifts potential reproductive contribution of population onto the shoulders of the young adults
Authors: Loi Barbara , Guala Ivan , Pires da Silva Rodrigo , Brundu Gianni , Baroli Maura , Farina Simone 
Published: March 2017

BackgroundIn Sardinia, as in other regions of the Mediterranean Sea, sustainable fisheries of the sea urchinParacentrotus lividushave become a necessity. At harvesting sites, the systematic removal of large individuals (diameter ≥ 50 mm) seriously compromises the biological and ecological functions of sea urchin populations. Specifically, in this study, we compared the reproductive potential of the populations from Mediterranean coastal areas which have different levels of sea urchin fishing pressure. The areas were located at Su Pallosu Bay, where pressure is high and Tavolara-Punta Coda Cavallo, a marine protected area where sea urchin harvesting is low.MethodsReproductive potential was estimated by calculating the gonadosomatic index (GSI) from June 2013 to May 2014 both for individuals of commercial size (diameter without spines, TD ≥ 50 mm) and the undersized ones with gonads (30 ≤ TD < 40 mm and 40 ≤ TD < 50 mm). Gamete output was calculated for the commercial-size class and the undersized individuals with fertile gonads (40 ≤ TD < 50 mm) in relation to their natural density (gamete output per m2).ResultsThe reproductive potential of populations was slightly different at the beginning of the sampling period but it progressed at different rates with an early spring spawning event in the high-pressure zone and two gamete depositions in early and late spring in the low-pressure zone. For each fertile size class, GSI values changed significantly during the year of our study and between the two zones. Although the multiple spawning events determined a two-fold higher total gamete output of population (popTGO) in the low-pressure zone, the population mean gamete output (popMGO) was similar in the two zones. In the high-pressure zone, the commercial-sized individuals represented approximatively 5% of the population, with almost all the individuals smaller than 60 mm producing an amount of gametes nearly three times lower than the undersized ones. Conversely, the high density of the undersized individuals released a similar amount of gametes to the commercial-size class in the low-pressure zone.DiscussionOverall, the lack of the commercial-size class in the high-pressure zone does not seem to be very alarming for the self-supporting capacity of the population, and the reproductive potential contribution seems to depend more on the total density of fertile sea urchins than on their size. However, since population survival in the high-pressure zone is supported by the high density of undersized sea urchins between 30 and 50 mm, management measures should be addressed to maintain these sizes and to shed light on the source of the larval supply.
A pseudo‐homozygous missense variant and Alu‐mediated exon 5 deletion in FARS2 causing spastic paraplegia 77
Authors: Lin Shu‐Huai , Xie Jun‐Hao , Jiang Jun‐Yi , Yan Xin‐Yu , Hong Chao‐Yin , Chen Wan‐Jin , Wang Ning , Lin Xiang 
Published: September 2024

AbstractFARS2‐associated hereditary spastic paraplegia, later onset spastic paraplegia type 77, is a rarely neurodegenerative disease. Here, we reported two affected siblings in an autosomal recessive spastic paraplegia family with a pseudo‐homozygous missense variant and Alu‐mediated exon 5 deletion in FARS2. Both patients gradually developed altered gaits and weakness in both lower limbs. In our literature review, spastic paraplegia type 77 shows high heterogeneity in clinical manifestations. Our study broadens the scope of pathogenic mechanisms of SPG77 resulting from compound heterozygous mutations in FARS2 and provides strong evidence that deletion in FARS2 due to recombination event mediated by Alu element.
Temporopolar blurring signifies abnormalities of white matter in mesial temporal lobe epilepsy
Authors: Li Yuming , Liu Peiwen , Lin Qiuxing , Li Wei , Zhang Yingying , Li Jinmei , Li Xiuli , Gong Qiyong , Zhang Heng , Li Luying , Sima Xiutian , Cao Danyang , Huang Xiang , Huang Kailing , Zhou Dong , An Dongmei 
Published: September 2024

AbstractObjectiveThe single‐center retrospective cohort study investigated underlying pathogenic mechanisms and clinical significance of patients with temporal lobe epilepsy and hippocampal sclerosis (TLE‐HS), in the presence/absence of gray–white matter abnormalities (usually called “blurring”; GMB) in ipsilateral temporopolar region (TPR) on MRI.MethodsThe study involved 105 patients with unilateral TLE‐HS (60 GMB+ and 45 GMB−) who underwent standard anterior temporal lobectomy, along with 61 healthy controls. Resected specimens were examined under light microscope. With combined T1‐weighted and DTI data, we quantitatively compared large‐scale morphometric features and exacted diffusion parameters of ipsilateral TPR‐related superficial and deep white matter (WM) by atlas‐based segmentation. Along‐tract analysis was added to detect heterogeneous microstructural alterations at various points along deep WM tracts, which were categorized into inferior longitudinal fasciculus (ILF), uncinate fasciculus (UF), and temporal cingulum.ResultsComparable seizure semiology and postoperative seizure outcome were found, while the GMB+ group had significantly higher rate of HS Type 1 and history of febrile seizures, contrasting with significantly lower proportion of interictal contralateral epileptiform discharges, HS Type 2, and increased wasteosomes in hippocampal specimens. Similar morphometric features but greater WM atrophy with more diffusion abnormalities of superficial WM was observed adjacent to ipsilateral TPR in the GMB+ group. Moreover, microstructural alterations resulting from temporopolar GMB were more localized in temporal cingulum while evenly and widely distributed along ILF and UF.InterpretationTemporopolar GMB could signify more severe and widespread microstructural damage of white matter rather than a focal cortical lesion in TLE‐HS, affecting selection of surgical procedures.
LncRNA‐Mediated TPI1 and PKM2 Promote Self‐Renewal and Chemoresistance in GBM
Authors: Yang Changxiao , Li Ziwei , Tian Kaifu , Meng Xiangqi , Wang Xinyu , Song Dan , Wang Xuan , Xu Tianye , Sun Penggang , Zhong Junzhe , Song Yu , Ma Wenbin , Liu Yuxiang , Yu Daohan , Shen Ruofei , Jiang Chuanlu , Cai Jinquan 
Published: September 2024

AbstractTemozolomide (TMZ) resistance is one of the major reasons for poor prognosis in patients with glioblastoma (GBM). Long noncoding RNAs (lncRNAs) are involved in multiple biological processes, including TMZ resistance. Linc00942 is a potential regulator of TMZ sensitivity in GBM cells is shown previously. However, the underlying mechanism of TMZ resistance induced by Linc00942 is unknown. In this study, the sequence of Linc00942 by rapid amplification of cDNA ends assay in TMZ‐resistant GBM cells is identified and confirmed that Linc00942 contributes to self‐renewal and TMZ resistance in GBM cells. Chromatin isolation by RNA purification followed by mass spectrometry (ChIRP‐MS) and followed by Western blotting (ChIRP‐WB) assays shows that Linc00492 interacted with TPI1 and PKM2, subsequently promoting their phosphorylation, dimerization, and nuclear translocation. The interaction of Linc00942 with TPI1 and PKM2 leads to increased acetylation of H3K4 and activation of the STAT3/P300 axis, resulting in the marked transcriptional activation of SOX9. Moreover, the knockdown of SOX9 reversed TMZ resistance induced by Linc00492 both in vitro and in vivo. In summary, Linc00942 strongly promotes SOX9 expression by interacting with TPI1 and PKM2 is found, thereby driving self‐renewal and TMZ resistance in GBM cells. These findings suggest potential combined therapeutic strategies to overcome TMZ resistance in patients with GBM.
Design Principles and Applications of Ionic Liquids for Transdermal Drug Delivery
Authors: Gao Sai , Cheng Xueqing , Zhang Ming , Dai Qiong , Liu Chaoyong , Lu Yunfeng 
Published: September 2024

AbstractIonic liquids (ILs) are salts with melting points typically <100 °C, composed of specific anions and cations. Recently, IL application has expanded into material engineering and biomedicine. Due to their unique properties, ILs have garnered significant interest in pharmacological research as solubilizers, transdermal absorption enhancers, antibacterial agents, and stabilizers of insoluble pharmaceutical active ingredients. The improvement of skin permeability by ILs is closely associated with their specific physicochemical characteristics, which are identified by their ionic composition. However, the existing literature on transdermal medication administration is insufficient in terms of a comprehensive knowledge base. This review provides a comprehensive assessment of the design principles involved in IL synthesis. Additionally, it discusses the methods utilized to assess skin permeability and provides a focused outline of IL application in transdermal drug administration.
Ionic Hydrogel‐Based Moisture Electric Generators for Underwater Electronics
Authors: Shen Daozhi , Li Fangzhou , Zhao Jian , Wang Rui , Li Bin , Han Zechao , Guo Linglan , Han Peicheng , Yang Dongqi , Kim Hyun Ho , Su Yanjie , Gong Zhixiong , Zhu Limin 
Published: September 2024

AbstractUbiquitous moisture is of particular interest for sustainable power generation and self‐powered electronics. However, current moisture electric generators (MEGs) can only harvest moisture energy in the air, which tremendously limits the energy harvesting efficiency and practical application scenarios. Herein, the operationality of MEG from air to underwater environment, through a sandwiched engineered‐hydrogel device with an additional waterproof breathable membrane layer allowing water vapor exchange while preventing liquid water penetration, is expanded. Underwater environment, the device can spontaneously deliver a voltage of 0.55 V and a current density of 130 µA cm−2 due to the efficient ion separation assisted by negative ions confinement in hydrogel networks. The output can be maintained even under harsh underwater environment with 10% salt concentration, 1 m s−1 disturbing flow, as well as >40 kPa hydraulic pressure. The engineered hydrogel used for MEG also exhibits excellent self‐healing ability, flexibility, and biocompatibility. As the first demonstration of practical applications in self‐powered underwater electronics, the MEG device is successfully powering a wireless emitter for remote communication in water. This new type of MEG offers an innovative route for harvesting moisture energy underwater and holds promise in the creation of a new range of innovative electronic devices for marine Internet‐of‐Things.