bluuebunny/crossref_metadata_2025_split huggingface dataset:
Self‐adaptation and mutual adaptation for distributed scheduling in benevolent clouds
Authors: Xiao Zheng , Liang Pijun , Tong Zhao , Li Kenli , Khan Samee U. , Li Keqin 
Published: September 2016

SUMMARYJoint service involving several clouds is an emerging form of cloud computing. In hybrid clouds, the schedulers within 1 cloud must not only self‐adapt to the job arrival processes and the workload but also mutually adapt to the scheduling polices of other schedulers. However, as a combinatorial optimization problem, scheduling is challenged by the adaptation to those dynamics and uncertain behaviors of the peers. This article studies the collaboration among benevolent clouds that are cooperative in nature and willing to accept jobs from other clouds. We take advantage of machine learning and propose a distributed scheduling mechanism to learn the knowledge of job model, resource performance, and others' policies. Without explicit modeling and prediction, machine learning guides scheduling decisions based on experiences. To examine the performance of our approach, we conducted simulation using the SP2 job workload log of the San Diego Supercomputer Center under a test bed based on agent‐based systems—SWARM. The results validate that our approach has much shorter mean response time than 5 typical dynamic scheduling algorithms—opportunistic load balancing, minimum execution time, minimum completion time, switching algorithm, and k‐percent best. A better collaboration in hybrid cloud is achieved by full adaptation.
Beneficial effects of treating waste secondary sludge with thermally activated persulfate
Authors: Akmehmet Balcioglu Isil , Bilgin Oncu Nalan , Mercan Nazire 
Published: September 2016

AbstractBACKGROUNDThe presence of numerous emerging contaminants including antimicrobials in waste activated sludge requires an effective treatment to reduce the risk of their dispersion in the environment in the case of land application. The potential ability of activated persulfate oxidation for organic contaminant destruction and sludge dewatering was subjected to detailed study to show the benefits of this process on sludge treatment.RESULTSTreatment of secondary waste sludge with persulfate thermally activated by microwave heating (S2O82−/MW), conventional heating (S2O82−/heat) and simultaneous conventional heating and ferrous iron (S2O82−/heat/Fe2+) were evaluated comparatively for both antimicrobial degradation and variation of sludge properties. Regardless of the activation type used in persulfate treatment, high degradations of model antimicrobials and shortened capillary suction time used to evaluate sludge dewaterability were obtained, with high destruction of tightly and loosely bound fractions of the extracellular polymeric substances.CONCLUSIONWhile S2O82−/MW treatment required shorter treatment period at 140 °C S2O82−/heat/Fe2+ treatment with a two‐fold lower dose of oxidant at 75 °C provided several other advantages including the minimization of adsorbable organic halogen species in the liquid phase of the sludge, enhancement of the overall metal solubilization, and precipitation of solubilized phosphorus. © 2016 Society of Chemical Industry
Quantitative assessment of gadolinium deposition in dentate nucleus using quantitative susceptibility mapping
Authors: Hinoda Takuya , Fushimi Yasutaka , Okada Tomohisa , Arakawa Yoshiki , Liu Chunlei , Yamamoto Akira , Okada Tsutomu , Yoshida Kazumichi , Miyamoto Susumu , Togashi Kaori 
Published: September 2016

PurposeGadolinium deposition in dentate nucleus (DN) has been reported after serial administration of gadolinium‐based contrast agents (GBCAs). Gadolinium complexes have paramagnetic properties; therefore, we evaluated susceptibility changes of gadolinium deposition in DN using quantitative susceptibility mapping (QSM) for patients after serial administration of GBCAs.Materials and MethodsIn all, 48 patients with brain tumors, who had had serial GBCA administrations (GBCA group), and 48 healthy volunteers without any history of GBCA administrations (non‐GBCA group) were enrolled in this study. Susceptibility values in DN on QSM and DN‐to‐cerebellum signal intensity ratios on unenhanced T1‐weighted images (T1 ratios) on 3T were analyzed. The relationship between the number of times of GBCA administrations and susceptibility values or T1 ratios were evaluated in the GBCA group.ResultsSusceptibility values at DN in the GBCA group were 0.107 ± 0.029 ppm, and significantly higher than those of the non‐GBCA group (0.079 ± 0.025 ppm) (P < 0.0001). T1 ratios in DN of the GBCA group were 1.059 ± 0.070, and also significantly higher than that of the non‐GBCA group (0.993 ± 0.016) (P < 0.0001). Spearman rank correlation coefficients between susceptibility values and the number of times of linear GBCA administration showed a modest significant correlation (ρ = 0.45, P = 0.0015). There was good correlation between T1 ratios and the number of times of linear GBCA administration, as reported previously (ρ = 0.76, P < 0.0001).ConclusionSusceptibility values on QSM in DN of the GBCA group, after serial administration of GBCAs, were significantly higher than those of the non‐GBCA group.Evidence Level: 3J. MAGN. RESON. IMAGING 2017;45:1352–1358
Intravoxel incoherent motion diffusion‐weighted imaging for characterizing focal hepatic lesions: Correlation with lesion enhancement
Authors: Choi In Young , Lee Seung Soo , Sung Yu Sub , Cheong Hyunhee , Lee Hoyoung , Byun Jae Ho , Kim So Yeon , Lee So Jung , Shin Yong Moon , Lee Moon‐gyu 
Published: September 2016

PurposeTo evaluate the value of intravoxel incoherent motion (IVIM) parameters for characterizing focal hepatic lesions, and to assess the correlation between IVIM parameters and arterial nodule enhancement.Materials and MethodsWe retrospectively evaluated 161 lesions (91 hepatocellular carcinomas [HCCs], 27 intrahepatic cholangiocarcinomas [IHCCs], 20 hemangiomas, 9 combined hepatocellular‐cholangiocarcinomas, 9 metastases, and 5 other tumors) in 161 patients (105 men and 56 women; mean age, 56.4 years). Diffusion‐weighted imaging was performed using nine b‐values (0–900 s/mm2) at 1.5T. Apparent diffusion coefficient (ADC), molecular diffusion coefficient (Dslow), perfusion fraction (f), and perfusion‐related diffusion coefficient (Dfast) were compared among the hepatic lesions using analysis of variance (ANOVA). Receiver‐operating‐characteristic analysis was performed to assess diagnostic performance. The enhancement fraction (EF) and the relative enhancement (RE) of the hepatic lesions on arterial phase gadoxetic acid‐enhanced images were correlated with the IVIM parameters using Spearman's test.ResultsFor the differentiation of hemangiomas from malignant tumors, Dslow showed the largest area under the curve (0.933) among all parameters. Although ADC did not show any difference among malignant lesions (P ≥ 0.28), HCCs showed a significantly lower Dslow than IHCC (P < 0.001) and a higher f than did IHCC (P < 0.001) and metastasis (P = 0.027); f had a significant positive correlation with EF (r = 0.420, P < 0.001) and RE (r = 0.264, P = 0.001).ConclusionIVIM parameters are more helpful in characterizing malignant hepatic lesions than ADC; f may reflect the extent and degree of hepatic nodule enhancement in the arterial phase, and may allow for differentiation of HCC from IHCC and metastasis.Level of Evidence: 3J. MAGN. RESON. IMAGING 2017;45:1589–1598
Cerebrospinal fluid dynamics at the lumbosacral level in patients with spinal stenosis: A pilot study
Authors: Chun Se‐Woong , Lee Hack‐Jin , Nam Koong‐Ho , Sohn Chul‐Ho , Kim Kwang Dong , Jeong Eun‐Jin , Chung Sun G. , Kim Keewon , Kim Dong‐Joo 
Published: September 2016

ABSTRACTSpinal stenosis is a common degenerative condition. However, how neurogenic claudication develops has not been clearly elucidated. Moreover, cerebrospinal fluid physiology at the lumbosacral level has not received adequate attention. This study was conducted to compare cerebrospinal fluid hydrodynamics at the lumbosacral spinal level between patients with spinal stenosis and healthy controls. Twelve subjects (four patients and eight healthy controls; 25–77 years old; seven males) underwent phase‐contrast magnetic resonance imaging to quantify cerebrospinal fluid dynamics. The cerebrospinal fluid flow velocities were measured at the L2 and S1 levels. All subjects were evaluated at rest and after walking (to provoke neurogenic claudication in the patients). The caudal peak flow velocity in the sacral spine (−0.25 ± 0.28 cm/s) was attenuated compared to that in the lumbar spine (−0.93 ± 0.46 cm/s) in both patients and controls. The lumbar caudal peak flow velocity was slower in patients (−0.65 ± 0.22 cm/s) than controls (−1.07 ± 0.49 cm/s) and this difference became more pronounced after walking (−0.66 ± 0.37 cm/s in patients, −1.35 ± 0.52 cm/s in controls; p = 0.028). The sacral cerebrospinal fluid flow after walking was barely detectable in patients (caudal peak flow velocity: −0.09 ± 0.03 cm/s). Cerebrospinal fluid dynamics in the lumbosacral spine were more attenuated in patients with spinal stenosis than healthy controls. After walking, the patients experiencing claudication did not exhibit an increase in the cerebrospinal fluid flow rate as the controls did. Altered cerebrospinal fluid dynamics may partially explain the pathophysiology of spinal stenosis. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:104–112, 2017.
Clinicopathologic features and prognosis of primary gastrointestinal stromal tumor patients under 35 years of age: A 10‐year retrospective study
Authors: Zhang Peng , Deng Rui , Liu Ke , Shuai Xiao‐Ming , Bai Jie , Chang Wei‐Long , Gao Jin‐Bo , Cai Kai‐Lin , Wang Guo‐Bin , Tao Kai‐Xiong 
Published: September 2016

ObjectivesTo investigate gastrointestinal stromal tumor (GIST) clinicopathologic characteristics in young adults.MethodsClinicopathologic data from GIST patients under 35 years diagnosed at our hospital from January 2005 to December 2014 were retrospectively collected.ResultsThirty‐one (5.3%, 31/585) patients were included; 17 (54.8%) were female. The most common presentation and primary tumor site were gastrointestinal bleeding (n = 18, 58.1%) and the small intestine (n = 13, 41.9%), respectively. Fifteen (48.4%) GISTs were classified as having a high relapse risk; two (6.4%), intermediate; nine (29.0%), low; and five (16.1%), very low. All patients underwent tumor resection. With a median follow‐up of 51 months for 20 (64.5%) patients, 12 (60%) were given imatinib methylate as adjuvant therapy. One (5%) patient died of peritoneal GIST dissemination, four (20%) developed abdominal recurrences, two (10%) had hepatic metastasis, and thirteen (65%) were disease free. The 5‐year disease‐free survival rate was 51.2%.ConclusionsGISTs rarely occur in young adults. The most common location is the small intestine. A slight female predominance was observed in the current study. Adjuvant therapy longer than the recommended duration may be beneficial for GISTs with a high relapse risk. Combined targeted therapy and surgery is appropriate for recurrent and metastatic GISTs in select patients. J. Surg. Oncol. 2016;114:977–981. © 2016 Wiley Periodicals, Inc.
Simulation of continuum electrical conduction and Joule heating using DEM domains
Authors: Hubert C. , André D. , Dubar L. , Iordanoff I. , Charles J.L. 
Published: September 2016

SummaryThis paper proposes an original method to simulate the electrical conduction in continuums with the Discrete Element Method (DEM). The proposed method is based on the graphs theory applied to electrical resistance network, where the resistance between two discrete elements is estimated through the notion of ‘transmission surface’ to assume the discrete domain as a continuous medium. In addition to the electrical conduction, the Joule heating of a DEM domain has also been developed to take full advantage of the electrical conduction. The proposed method has been implemented in the free DEM software named ‘GranOO’.The numerical results were compared against analytical approaches when applicable, or against Finite Element Method if the geometries become more complex or in case of dynamic loadings. The results are found satisfactory with errors around 3% for the electrical conduction and Joule heating of reasonably complex domains and loading cases. When it comes to more complex domains, such as electrical constriction, whilst the results remain close to those obtained with reference solutions (around 6%), they highlight the importance of taking care about the domains discretization.Finally, the proposed method is applied to detect cracks onset on a cylindrical rod torsion test to show how to take advantage of the proposed work. Copyright © 2016 John Wiley & Sons, Ltd.
MicroRNA‐463‐3p/ABCG4: A new axis in glucose‐stimulated insulin secretion
Authors: Hou Xuwei , Wu Wei , Yin Bo , Liu Xuefeng , Ren Fu 
Published: September 2016

ObjectiveGlucose‐stimulated insulin secretion (GSIS) is known to be essential in the control of metabolic fuel homeostasis, though the molecular mechanisms involved remain unclear.MethodsMicroRNA (miRNA)−463‐3p and ATP‐binding cassette A4 (ABCG4) expression was analyzed by real‐time PCR, and the potential role of miRNA‐463‐3p or ABCG4 was evaluated by overexpressing or silencing such miRNA or genes.ResultsThe miRNA‐463‐3p inhibited GSIS without affecting cell viability. Further, mechanistic studies demonstrated that ABCG4 was a direct target of microRNA‐463‐3p and, to this effect, that ABCG4 played an important role in GSIS. The targeting was relevant in pancreatic islet β‐cells, where GSIS through the miRNA‐463‐3p/ABCG4 axis was observed. Interestingly, in type 2 diabetes human pancreatic islets, expression of miRNA‐463‐3p and insulin was upregulated and ABCG4 downregulated compared with nondiabetic controls, and their expression levels were closely correlated.ConclusionsThe findings collectively establish a link between GSIS and the miRNA‐463‐3p/ABCG4 axis and represent a promising target for future diabetes mellitus treatments.
Inner surface modification of halloysite nanotubes and its influence on morphology and thermal properties of polystyrene/polyamide‐11 blends
Authors: Sahnoune Mohamed , Taguet Aurélie , Otazaghine Belkacem , Kaci Mustapha , Lopez‐Cuesta José‐Marie 
Published: September 2016

AbstractThe asymmetry of halloysite surface chemistry was used to perform a selective modification of its inner surface via grafting of a synthesized styrene/(methacryloyloxy)methyl phosphonic acid copolymer. Fourier transform infrared spectroscopy, thermogravimetric analysis (TGA) and pyrolysis gas chromatography/mass spectrometry were used to evidence and quantify the grafting. Then, raw and hybrid nanoparticles were incorporated in polystyrene (PS)/polyamide‐11 (PA11) blends (80/20 and 60/40 wt%). Scanning electron micrographs showed differences in localization of the halloysite nanotubes (HNTs), since raw halloysite is concentrated in the PA11 phase while modified halloysite is also located at the PS/PA11 interface, leading to a better interfacial adhesion between PS and PA11. An inhibiting effect of modified halloysite on PA11 coalescence was evidenced by measuring the particle size distribution of the extracted nodules. Moreover, the presence of modified halloysite at the interface shows an improvement in terms of thermal stability as observed by TGA, but with no significant effects on PA11 crystallization behaviour as shown by differential scanning calorimetry results. Rheological measurements were carried out to study the influence of the surface modification of halloysite on the blend morphology. A gel‐like behaviour was observed for the (60/40 wt%) HNTs reinforced composition that was enhanced in the case of 10% functionalized halloysite. © 2016 Society of Chemical Industry
Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis
Authors: Khalfallah Olfa , Jarjat Marielle , Davidovic Laetitia , Nottet Nicolas , Cestèle Sandrine , Mantegazza Massimo , Bardoni Barbara 
Published: September 2016

Abstract
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and a leading cause of autism. FXS is due to the silencing of the Fragile X Mental Retardation Protein (FMRP), an RNA binding protein mainly involved in translational control, dendritic spine morphology and synaptic plasticity. Despite extensive studies, there is currently no cure for FXS. With the purpose to decipher the initial molecular events leading to this pathology, we developed a stem-cell-based disease model by knocking-down the expression of Fmr1 in mouse embryonic stem cells (ESCs). Repressing FMRP in ESCs increased the expression of amyloid precursor protein (APP) and Ascl1. When inducing neuronal differentiation, βIII-tubulin, p27kip1, NeuN, and NeuroD1 were upregulated, leading to an accelerated neuronal differentiation that was partially compensated at later stages. Interestingly, we observed that neurogenesis is also accelerated in the embryonic brain of Fmr1-knockout mice, indicating that our cellular model recapitulates the molecular alterations present in vivo. Importantly, we rescued the main phenotype of the Fmr1 knockdown cell line, not only by reintroducing FMRP but also by pharmacologically targeting APP processing, showing the role of this protein in the pathophysiology of FXS during the earliest steps of neurogenesis. Our work allows to define an early therapeutic window but also to identify more effective molecules for treating this disorder.
Concise Review: Lessons from Naïve Human Pluripotent Cells
Authors: Ware Carol B. 
Published: September 2016

Abstract
The naïve state of pluripotency is actively being explored by a number of labs. There is some controversy in the field as to the true identity of naïve human pluripotent cells as they are not exact mirrors of the mouse. The various reports published, although in basic agreement, present discrepancies in the characterization of the various lines, which likely reflect the etiology of these lines. The primary lesson learned from these contributions is that a human naïve state reflecting the preimplantation human is likely to exist. The essential factors that will universally maintain the naïve state in human cells in vitro are not yet fully understood. These first need to be identified in order to describe the definitive characteristics of this state. Comparisons of naïve and primed human pluripotent cells have also highlighted consistencies between states and broadened our understanding of embryonic metabolism, epigenetic change required for development, embryonic DNA repair strategies and embryonic expression dynamics.
Phytosterol Esterification is Markedly Decreased in Preterm Infants Receiving Routine Parenteral Nutrition
Authors: Savini Sara , Correani Alessio , Pupillo Daniele , D'Ascenzo Rita , Biagetti Chiara , Pompilio Adriana , Simonato Manuela , Verlato Giovanna , Cogo Paola , Taus Marina , Nicolai Albano , Carnielli Virgilio Paolo 
Published: September 2016

AbstractSeveral studies reported the association between total plasma phytosterol concentrations and the parenteral nutrition‐associated cholestasis (PNAC). To date, no data are available on phytosterol esterification in animals and in humans during parenteral nutrition (PN). We measured free and esterified sterols (cholesterol, campesterol, stigmasterol, and sitosterol) plasma concentrations during PN in 16 preterm infants (500–1249 g of birth weight; Preterm‐PN), in 11 term infants (Term‐PN) and in 12 adults (Adult‐PN). Gas chromatography–mass spectrometry was used for measurements. Plasma concentrations of free cholesterol (Free‐CHO), free phytosterols (Free‐PHY) and esterified phytosterols (Ester‐PHY) were not different among the three PN groups. Esterified cholesterol (Ester‐CHO) was statistically lower in Preterm‐PN than Adult‐PN. Preterm‐PN had significantly higher Free‐CHO/Ester‐CHO and Free‐PHY/Ester‐PHY ratios than Adult‐PN (Free‐CHO/Ester‐CHO: 1.1 ± 0.7 vs. 0.6 ± 0.2; Free‐PHY/Ester‐PHY: 4.1 ± 2.6 vs. 1.3 ± 0.8; *P < 0.05). Free‐CHO/Ester‐CHO and Free‐PHY/Ester‐PHY ratios of Term‐PN (Free‐CHO/Ester‐CHO: 1.1 ± 0.4; Free‐PHY/Ester‐PHY: 2.9 ± 1.7) were not different from either Preterm‐PN or from Adult‐PN. Plasma Free‐CHO/Ester‐CHO and Free‐PHY/Ester‐PHY were unchanged after 24 h on fat‐free PN both in Preterm‐PN and in Adult‐PN. Free‐PHY/Ester‐PHY did not correlate with phytosterol intake in Preterm‐PN. Free‐PHY/Ester‐PHY of Preterm‐PN was positively correlated with the Free‐CHO/Ester‐CHO and negatively correlated with gestational age and birth weight. In conclusion, PHY were esterified to a lesser extent than CHO in all study groups; the esterification was markedly decreased in Preterm‐PN compared to Adult‐PN. The clinical consequences of these findings warrant further investigations.
Go beyond just paying: Effects of payment method on level of construal
Authors: Chen Rong , Xu Xiaobing , Shen Hao 
Published: September 2016

AbstractDoes paying by credit card induce consumers to think more abstractly than paying in cash? In a series of five studies, we show that priming people with a concept of a credit card as the payment method could lead them to construe information more abstractly than priming them with a concept of cash as the payment method. We distinguish between two processes that might account for the above effect, examine the factors that moderate this effect, and demonstrate the marketing implications of our findings.
Sexual Satisfaction and the Importance of Sexual Health to Quality of Life Throughout the Life Course of U.S. Adults
Authors: Flynn Kathryn E. , Lin Li , Bruner Deborah Watkins , Cyranowski Jill M. , Hahn Elizabeth A. , Jeffery Diana D. , Reese Jennifer Barsky , Reeve Bryce B. , Shelby Rebecca A. , Weinfurt Kevin P. 
Published: September 2016

ABSTRACTIntroductionDiscussions about sexual health are uncommon in clinical encounters, despite the sexual dysfunction associated with many common health conditions. Understanding of the importance of sexual health and sexual satisfaction in U.S. adults is limited.AimTo provide epidemiologic data on the importance of sexual health for quality of life and people's satisfaction with their sex lives and to examine how each is associated with demographic and health factors.MethodsData are from a cross-sectional self-report questionnaire from a sample of 3,515 English-speaking U.S. adults recruited from an online panel that uses address-based probability sampling.Main Outcome MeasuresWe report ratings of importance of sexual health to quality of life (single item with five-point response) and the Patient-Reported Outcomes Measurement Information System Satisfaction With Sex Life score (five items, each with five-point responses, scores centered on the U.S. mean).ResultsHigh importance of sexual health to quality of life was reported by 62.2% of men (95% CI = 59.4–65.0) and 42.8% of women (95% CI = 39.6–46.1, P &lt; .001). Importance of sexual health varied by sex, age, sexual activity status, and general self-rated health. For the 55% of men and 45% of women who reported sexual activity in the previous 30 days, satisfaction with sex life differed by sex, age, race-ethnicity (among men only), and health. Men and women in excellent health had significantly higher satisfaction than participants in fair or poor health. Women with hypertension reported significantly lower satisfaction (especially younger women), as did men with depression or anxiety (especially younger men).ConclusionIn this large study of U.S. adults' ratings of the importance of sexual health and satisfaction with sex life, sexual health was a highly important aspect of quality of life for many participants, including participants in poor health. Moreover, participants in poorer health reported lower sexual satisfaction. Accordingly, sexual health should be a routine part of clinicians' assessments of their patients. Health care systems that state a commitment to improving patients' overall health must have resources in place to address sexual concerns. These resources should be available for all patients across the lifespan.