bluuebunny/crossref_metadata_2025_split huggingface dataset:
Real-time Acute Stress Facilitates Allocentric Spatial Processing in a Virtual Fire Disaster
Authors: Cao Zhengcao , Wang Yamin , Zhang Liang 
Published: October 2017

AbstractPrior studies have shown that spatial cognition is influenced by stress prior to task. The current study investigated the effects of real-time acute stress on allocentric and egocentric spatial processing. A virtual reality-based spatial reference rule learning (SRRL) task was designed in which participants were instructed to make a location selection by walking to one of three poles situated around a tower. A selection was reinforced by either an egocentric spatial reference rule (leftmost or rightmost pole relative to participant) or an allocentric spatial reference rule (nearest or farthest pole relative to the tower). In Experiment 1, 32 participants (16 males, 16 females; aged from 18 to 27) performed a SRRL task in a normal virtual reality environment (VRE). The hit rates and rule acquisition revealed no difference between allocentric and egocentric spatial reference rule learning. In Experiment 2, 66 participants (32 males, 34 females; aged from 19 to 30) performed the SRRL task in both a low-stress VRE (a mini virtual arena) and a high-stress VRE (mini virtual arena with a fire disaster). Allocentric references facilitated learning in the high-stressful VRE. The results suggested that acute stress facilitate allocentric spatial processing.
On the observability of Pauli crystals in experiments with ultracold trapped Fermi gases
Authors: Rakshit Debraj , Mostowski Jan , Sowiński Tomasz , Załuska-Kotur Magdalena , Gajda Mariusz 
Published: October 2017

AbstractThe best known manifestation of the Fermi-Dirac statistics is the Pauli exclusion principle: no two identical fermions can occupy the same one-particle state. This principle enforces high-order correlations in systems of many identical fermions and is responsible for a particular geometric arrangement of trapped particles even when all mutual interactions are absent. These geometric structures, called Pauli crystals, are predicted for a system of N identical atoms trapped in a harmonic potential. They emerge as the most frequent configurations in a collection of single-shot pictures of the system. Here we study how fragile Pauli crystals are when realistic experimental limitations are taken into account. The influence of the number of single-shots pictures available to analysis, thermal fluctuations and finite efficiency of detection are considered. The role of these sources of noise on the possibility of experimental observation of Pauli crystals is shown and conditions necessary for the detection of the geometrical arrangements of particles are identified.
Anti-inflammatory and anti-fibrotic effects of intravenous adipose-derived stem cell transplantation in a mouse model of bleomycin-induced interstitial pneumonia
Authors: Kotani Takuya , Masutani Ryota , Suzuka Takayasu , Oda Katsuhiro , Makino Shigeki , Ii Masaaki 
Published: October 2017

AbstractAdipose-derived stem cells (AdSCs) have recently been considered a useful treatment tool for autoimmune disease because of their anti-inflammatory and immunosuppressive effects. We investigated the therapeutic effect of intravenous AdSC transplantation in a mouse model of bleomycin-induced lung injury. AdSCs accumulated in the pulmonary interstitium and inhibited both inflammation and fibrosis in the lung, markedly improving the survival rate of mice with bleomycin-induced lung injury in a cell number-dependent manner. AdSCs inhibited the production of pro-inflammatory cytokines such as TNF-α and IL-12 in activated macrophages, and AdSCs also induced the apoptosis of activated macrophages. AdSCs inhibited the differentiation and proliferation of Th2-type mCD4+ T cells but promoted the differentiation and proliferation of regulatory T cells, suggesting that the phenotypic conversion of T cells may be one of the mechanisms for the anti-inflammatory effect of AdSCs on pulmonary fibrosis. These findings suggest that intravenous AdSCs could be a promising treatment for patients with interstitial pneumonia.
Task-Correlated Cortical Asymmetry and Intra- and Inter-Hemispheric Separation
Authors: Cohen Yaniv , Wilson Donald A. 
Published: October 2017

AbstractCerebral lateralization is expressed at both the structural and functional levels, and can exist as either a stable characteristic or as a dynamic feature during behavior and development. The anatomically relatively simple olfactory system demonstrates lateralization in both human and non-human animals. Here, we explored functional lateralization in both primary olfactory cortex – a region critical for odor memory and perception- and orbitofrontal cortex (OFC) – a region involved in reversal learning- in rats performing an odor learning and reversal task. We find significant asymmetry in both olfactory and orbitofrontal cortical odor-evoked activity, which is expressed in a performance- and task-dependent manner. The emergence of learning-dependent asymmetry during reversal learning was associated with decreased functional connectivity both between the bilateral OFC and between the OFC-olfactory cortex. The results suggest an inter-hemispheric asymmetry and olfactory cortical functional separation that may allow multiple, specialized processing circuits to emerge during a reversal task requiring behavioral flexibility.
Integrated plasmon-enhanced Raman scattering (iPERS) spectroscopy
Authors: Wang Hailong , Li Haibo , Xu Shuping , Zhao Bing , Xu Weiqing 
Published: November 2017

AbstractA new strategy named integrated plasmon-enhanced Raman scattering (iPERS) spectroscopy that features a configuration of evanescent field excitation and inverted collection is presented, which well unites the local field enhancement and far field emission, couples localized and propagating surface plasmons, integrates the SERS substrates and Raman spectrometers via a self-designed aplanatic solid immersion lens. A metallic nanoparticle-on-a film (NOF) system was adopted in this configuration because it improves the amplification of the incidence light field in near field by 10 orders of magnitude due to the simultaneous excitation of quadrupolar and dipolar resonance modes. This iPERS allows for higher excitation efficiency to probed molecules and full collection of the directional-radiation Raman scattering signal in an inverted way, which exhibits a practical possibility to monitor plasmonic photocatalytic reactions in nanoscale and a bright future on interfacial reaction studies.
A Functional Study of Human Inflammatory Arthritis Using Photoacoustic Imaging
Authors: Jo Janggun , Xu Guan , Cao Meng , Marquardt April , Francis Sheeja , Gandikota Girish , Wang Xueding 
Published: October 2017

AbstractBy using our dual-modality system enabling simultaneous real-time ultrasound (US) and photoacoustic (PA) imaging of human peripheral joints, we explored the potential contribution of PA imaging modality to rheumatology clinic. By performing PA imaging at a single laser wavelength, the spatially distributed hemoglobin content reflecting the hyperemia in synovial tissue in metacarpophalangeal (MCP) joints of 16 patients were imaged, and compared to the results from 16 healthy controls. In addition, by performing PA imaging at two laser wavelengths, the spatially distributed hemoglobin oxygenation reflecting the hypoxia in inflammatory joints of 10 patients were imaged, and compared to the results from 10 healthy controls. The statistical analyses of the PA imaging results demonstrated significant differences (p < 0.001) in quantified hemoglobin content and oxygenation between the unequivocally arthritic joints and the normal joints. Increased hyperemia and increased hypoxia, two important physiological biomarkers of synovitis reflecting the increased metabolic demand and the relatively inadequate oxygen delivery in affected synovium, can both be objectively and non-invasively evaluated by PA imaging. The proposed dual-modality system has the potential of providing additional diagnostic information over the traditional US imaging approaches and introducing novel imaging biomarkers for diagnosis and treatment evaluation of inflammatory arthritis.
Determination of total and unbound docetaxel in plasma by ultrafiltration and UPLC-MS/MS: application to pharmacokinetic studies
Authors: Sheu Ming-Thau , Wu Chen-Yuan , Su Chia-Yu , Ho Hsiu-O 
Published: October 2017

AbstractA sensitive and specific liquid chromatographic/tandem mass spectrometric (LC-MS/MS) method was developed and validated for quantifying total and unbound docetaxel drug concentrations in plasma. Calibration curves for unbound and total docetaxel were linear over the respective ranges of 0.108~10.8 and 0.54~216 ng/mL. The intra- and interday assay accuracy and precision did not exceed 15%. The methods were validated to show the standard range linearity, sensitivity, selectivity, accuracy, precision, and stability of docetaxel in the matrices tested. In addition, this method is fast and simple with a short run time of 4.5 min and a small plasma sample volume (500 µL). The validated method was successfully applied to a pharmacokinetic study of a docetaxel micelle formulation in rat plasma after intravenous administration at a dose of 10 mg/kg. Docetaxel micelles slowly released their drug payload, and protein-bound, unbound, and micellar drug pools existed simultaneously. These various forms in plasma pools were also measured in the study. We confirmed that most of the docetaxel in plasma was micelle-associated (96.52% at 24 h and 83.14% at 72 h) after micellar docetaxel administration, as a result of sequestration of the drug in long-circulating micelles.
Context-dependent compensation among phosphatidylserine-recognition receptors
Authors: Penberthy Kristen K. , Rival Claudia , Shankman Laura S. , Raymond Michael H. , Zhang Jianye , Perry Justin S. A. , Lee Chang Sup , Han Claudia Z. , Onengut-Gumuscu Suna , Palczewski Krzysztof , Lysiak Jeffrey J. , Ravichandran Kodi S. 
Published: November 2017

AbstractPhagocytes express multiple phosphatidylserine (PtdSer) receptors that recognize apoptotic cells. It is unknown whether these receptors are interchangeable or if they play unique roles during cell clearance. Loss of the PtdSer receptorMertkis associated with apoptotic corpse accumulation in the testes and degeneration of photoreceptors in the eye. Both phenotypes are linked to impaired phagocytosis by specialized phagocytes: Sertoli cells and the retinal pigmented epithelium (RPE). Here, we overexpressed the PtdSer receptor BAI1 in mice lacking MerTK (Mertk−/−Bai1Tg) to evaluate PtdSer receptor compensationin vivo. WhileBai1overexpression rescues clearance of apoptotic germ cells in the testes ofMertk−/−mice it fails to enhance RPE phagocytosis or prevent photoreceptor degeneration. To determine why MerTK is critical to RPE function, we examined visual cycle intermediates and performed unbiased RNAseq analysis of RPE fromMertk+/+andMertk−/−mice. Prior to the onset of photoreceptor degeneration,Mertk−/−mice had less accumulation of retinyl esters and dysregulation of a striking array of genes, including genes related to phagocytosis, metabolism, and retinal disease in humans. Collectively, these experiments establish that not all phagocytic receptors are functionally equal, and that compensation among specific engulfment receptors is context and tissue dependent.
Serial dependence is absent at the time of perception but increases in visual working memory
Authors: Bliss Daniel P. , Sun Jerome J. , D’Esposito Mark 
Published: November 2017

AbstractRecent experiments have shown that visual cognition blends current input with that from the recent past to guide ongoing decision making. This serial dependence appears to exploit the temporal autocorrelation normally present in visual scenes to promote perceptual stability. While this benefit has been assumed, evidence that serial dependence directly alters stimulus perception has been limited. In the present study, we parametrically vary the delay between stimulus and response in a spatial delayed response task to explore the trajectory of serial dependence from the moment of perception into post-perceptual visual working memory. We find that behavioral responses made immediately after viewing a stimulus show evidence of adaptation, but not attractive serial dependence. Only as the memory period lengthens is a blending of past and present information apparent in behavior, reaching its maximum with a delay of six seconds. These results dovetail with other recent findings to bolster the interpretation that serial dependence is a phenomenon of mnemonic rather than perceptual processes. However, even while this pattern of effects in group-averaged data has now been found consistently, we show that the relative strengths of adaptation and serial dependence vary widely across individuals. Finally, we demonstrate that when leading mathematical models of working memory are adjusted to account for these trial-history effects, their fit to behavioral data is substantially improved.
Characterization of ApoJ-reconstituted high-density lipoprotein (rHDL) nanodisc for the potential treatment of cerebral β-amyloidosis
Authors: Fernández-de-Retana Sofía , Cano-Sarabia Mary , Marazuela Paula , Sánchez-Quesada Jose Luis , Garcia-Leon Annabel , Montañola Alex , Montaner Joan , Maspoch Daniel , Hernández-Guillamon Mar 
Published: November 2017

AbstractCerebral β-amyloidosis is a major feature of Alzheimer’s disease (AD), characterized by the accumulation of β-amyloid protein (Aβ) in the brain. Several studies have implicated lipid/lipoprotein metabolism in the regulation of β-amyloidosis. In this regard, HDL (High Density Lipoprotein)-based therapies could ameliorate pathological features associated with AD. As apolipoprotein J (ApoJ) is a natural chaperone that interacts with Aβ, avoiding its aggregation and toxicity, in this study we propose to prepare reconstituted rHDL-rApoJ nanoparticles by assembling phospholipids with recombinant human ApoJ (rApoJ). Hence, rHDL particles were prepared using the cholate dialysis method and characterized by N-PAGE, dynamic light scattering, circular dichroism and electron transmission microscopy. The preparation of rHDL particles showed two-sized populations with discoidal shape. Functionally, rHDL-rApoJ maintained the ability to prevent the Aβ fibrillization and mediated a higher cholesterol efflux from cultured macrophages. Fluorescently-labelled rHDL-rApoJ nanoparticles were intravenously administrated in mice and their distribution over time was determined using an IVIS Xenogen® imager. It was confirmed that rHDL-rApoJ accumulated in the cranial region, especially in old transgenic mice presenting a high cerebral Aβ load. In conclusion, we have standardized a reproducible protocol to produce rHDL-rApoJ nanoparticles, which may be potentially considered as a therapeutic option for β-amyloid-related pathologies.
Fabrication of Artificial Leaf to Develop Fluid Pump Driven by Surface Tension and Evaporation
Authors: Lee Minki , Lim Hosub , Lee Jinkee 
Published: November 2017

AbstractPlants transport water from roots to leaves via xylem through transpiration, which is an evaporation process that occurs at the leaves. During transpiration, suction pressure is generated by the porous structure of mesophyll cells in the leaves. Here, we fabricate artificial leaf consisting of micro and nano hierarchy structures similar to the mesophyll cells and veins of a leaf using cryo-gel method. We show that the microchannels in agarose gel greatly decrease the flow resistance in dye diffusion and permeability experiments. Capillary tube and silicone oil are used for measuring the suction pressure of the artificial leaf. We maintain low humidity (20%) condition for measuring suction pressure that is limited by Laplace pressure, which is smaller than the water potential of air followed by the Kelvin-Laplace relation. Suction pressure of the artificial leaf is maximized by changing physical conditions, e.g., pore size, wettability of the structure. We change the agarose gel’s concentration to decrease the pore size down to 200 nm and add the titanium nano particles to increase the wettability by changing contact angle from 63.6° to 49.4°. As a result, the measured suction pressure of the artificial leaf can be as large as 7.9 kPa.
Self-deception in and out of illness: are some subjects responsible for their delusions?
Authors: Gibson Quinn Hiroshi 
Published: October 2017

AbstractThis paper raises a slightly uncomfortable question: are some delusional subjects responsible for their delusions? This question is uncomfortable because we typically think that the answer is pretty clearly just ‘no’. However, we also accept thatself-deceptionis paradigmatically intentional behavior for which the self-deceiver isprima facieblameworthy. Thus, if there is overlap between self-deception and delusion, this will put pressure on our initial answer. This paper argues that there is indeed such overlap by offering a novel philosophical account of self-deception. The account offered is independently plausible and avoids the main problems that plague other views. It also yields the result that some delusional subjects are self-deceived. The conclusion is not, however, that those subjects are blameworthy. Rather, a distinction is made between blameworthiness and ‘attributability’. States or actions can be significantly attributable to a subject—in the sense that they are expressions of their wills—without it being the case that the subject is blameworthy, if the subject has an appropriate excuse. Understanding delusions within this framework of responsibility and excuses not only illuminates the ways in which the processes of delusional belief formation and maintenance are continuous with ‘ordinary’ processes of belief formation and maintenance, it also provides a way of understanding the innocence of the delusional subject that does not involve the denial of agency.
Early T cell receptor signals globally modulate ligand:receptor affinities during antigen discrimination
Authors: Pielak Rafal M. , O’Donoghue Geoff P. , Lin Jenny J. , Alfieri Katherine N. , Fay Nicole C. , Low-Nam Shalini T. , Groves Jay T. 
Published: October 2017

Significance
Antigen discrimination by T cells is based on subtle differences in binding of the T cell receptor (TCR) for its peptide major histocompatibility complex (pMHC) ligand. While such binding characteristics are readily mapped with great precision in reconstituted biochemical systems, it is less clear how these interactions are affected in the live cell environment. Here we utilize single-molecule imaging to individually resolve all of the pMHC:TCR binding events in live T cells. The quantitative measurements reveal an active feedback mechanism that globally modulates the probability of pMHC:TCR binding throughout the cell–cell interface, without affecting the unbinding rate. The result is to increase the efficiency with which TCRs scan for antigen pMHC after the first few molecular encounters have occurred.
Strong texturing of lithium metal in batteries
Authors: Shi Feifei , Pei Allen , Vailionis Arturas , Xie Jin , Liu Bofei , Zhao Jie , Gong Yongji , Cui Yi 
Published: October 2017

Significance
This work represents a first attempt to study the crystallographic texture of Li metal in batteries. X-ray diffraction pole-figure analysis demonstrates that the texture of Li deposition is primarily dependent on the type of additive or cross-over molecule from the cathode side. We find that reversibility of Li, which is phenomenologically influenced by morphology, is fundamentally driven by the texture (crystallographic orientation). Additives in electrolytes and the cross-over molecules from the cathode play crucial roles on the crystallographic texture because they hinder the cathodic process and selectively adsorb/react on different crystal planes. Additives with favorable adsorption and reusability will generate controllable texture, resulting in more uniform morphology and better cycling reversibility.
Cooperative cortical network for categorical processing of Chinese lexical tone
Authors: Si Xiaopeng , Zhou Wenjing , Hong Bo 
Published: October 2017

Significance
The variation of pitch in speech not only creates the intonation for affective communication but also signals different meaning of a word in tonal languages, like Chinese. Due to its subtle and brisk pitch contour distinction between tone categories, the underlying neural processing mechanism is largely unknown. Using direct recordings of the human brain, we found categorical neural responses to lexical tones over a distributed cooperative network that included not only the auditory areas in the temporal cortex but also motor areas in the frontal cortex. Strong causal links from the temporal cortex to the motor cortex were discovered, which provides new evidence of top-down influence and sensory–motor interaction during speech perception.
Direct observation of impact propagation and absorption in dense colloidal monolayers
Authors: Buttinoni Ivo , Cha Jinwoong , Lin Wei-Hsun , Job Stéphane , Daraio Chiara , Isa Lucio 
Published: October 2017

Significance
Single-particle characterization of the impact response has unveiled design principles to focus and control stress propagation in macroscopic granular crystalline arrays. We demonstrate that similar principles apply to aqueous monolayers of microparticles excited by localized mechanical pulses. By inducing extreme local deformation rates and tracking the motion of each particle with velocities that reach up to few meters per second, we reveal that a regime of elastic collisions, typically forbidden due to overdamping, becomes accessible. This provides insights on the stress propagation and energy absorption of dense suspensions upon fast deformation rates.
Probing the cooperativity of
Thermoplasma acidophilum
proteasome core particle gating by NMR spectroscopy
Authors: Huang Rui , Pérez Felipe , Kay Lewis E. 
Published: October 2017

Significance
In the cell, protein degradation occurs, to a large extent, by a barrel-like structure called the proteasome. Degradation is highly regulated, ensuring that only proteins targeted for elimination are removed. This is accomplished through gates that close the proteasome entrance pores, localized to the top and bottom of the structure, as well as through the binding of regulator molecules. Here, we study the properties of the individual gates using solution NMR spectroscopy and a labeling procedure in which a series of molecules are prepared with subunits that have different types of gates. Our results show that gates are formed via residues that have a very high intrinsic propensity to enter the lumen of the proteasome, with each gate behaving independently.
Genomic features shaping the landscape of meiotic double-strand-break hotspots in maize
Authors: He Yan , Wang Minghui , Dukowic-Schulze Stefanie , Zhou Adele , Tiang Choon-Lin , Shilo Shay , Sidhu Gaganpreet K. , Eichten Steven , Bradbury Peter , Springer Nathan M. , Buckler Edward S. , Levy Avraham A. , Sun Qi , Pillardy Jaroslaw , Kianian Penny M. A. , Kianian Shahryar F. , Chen Changbin , Pawlowski Wojciech P. 
Published: October 2017

Significance
Meiotic recombination is a process in plants, animals, and fungi during which chromosomes exchange their parts. It generates new genetic variation in the progeny and is one of the reasons why progeny are both similar to and different from their parents. Recombination is initiated by formation of breaks in chromosomal DNA. We generated a high-resolution map of sites where these breaks are formed in the genome of maize. Surprisingly, we found that DNA breaks are abundant in all genome regions, including sites where recombination was thought to be limited, such as repetitive DNA. The map will allow understanding of how recombination patterns shape the genome and aid development of more efficient breeding methods.