bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive impairment in progressive supranuclear palsy is associated with tau burden
Authors: Koga Shunsuke , Parks Adam , Kasanuki Koji , Sanchez‐Contreras Monica , Baker Matthew C. , Josephs Keith A. , Ahlskog J. Eric , Uitti Ryan J. , Graff‐Radford Neill , van Gerpen Jay A. , Wszolek Zbigniew K. , Rademakers Rosa , Dickson Dennis W. 
Published: October 2017

AbstractBackgroundCognitive impairment is one of the core features of progressive supranuclear palsy. This study aimed to clarify the profile of cognitive impairment and its underlying pathology in progressive supranuclear palsy.MethodsWe retrospectively reviewed medical records to evaluate the pattern and severity of cognitive impairment in 121 autopsy‐confirmed progressive supranuclear palsy patients. A subset of 37 patients underwent neuropsychological evaluation as part of their clinical workup. The burden of progressive supranuclear palsy‐related tau pathology (neurofibrillary tangles/pretangles, coiled bodies, tufted astrocytes, and threads) was semiquantitatively scored in 20 vulnerable brain regions. Concurrent pathologies potentially associated with cognitive impairment, such as Alzheimer's‐type pathology, were also assessed. To evaluate possible genetic risk factors for cognitive impairment, genetic analysis for APOE and MAPT was performed.ResultsNinety patients (74%) had documented cognitive impairment based on neurologic evaluation. In a subgroup with neuropsychological testing (n = 37), executive functioning was the most severely impaired cognitive domain. A global cognitive impairment index (Spearman's rho, −0.49; P = 0.005) and executive functioning were negatively correlated with total tau burden (Spearman's rho, −0.51; P = 0.003), but not correlated with the Alzheimer's‐type pathology. APOE ɛ4 carriers had more severe amyloid pathology, but total tau burden and a global cognitive impairment index did not differ from APOE ɛ4 noncarriers.ConclusionCognitive impairment in progressive supranuclear palsy, most notably executive dysfunction, is associated with severity of progressive supranuclear palsy‐related tau pathology. © 2017 International Parkinson and Movement Disorder Society
Dietary Glycation Products Regulate Immune Homeostasis: Early Glycation Products Promote Prostate Cancer Cell Proliferation through Modulating Macrophages
Authors: Chen Yingjia , Filipov Nikolay M. , Guo Tai L. 
Published: October 2017

ScopeWell‐controlled glycation (generally limited to the early stages) has been proposed as a strategy to improve the physiochemical properties of dietary proteins, but the functional studies of glycation products are mostly on advanced glycation end‐products (AGEs) rather than early glycation products (EGPs). Since cytokines are important modulators of various biological processes, this study aims to determine whether EGPs and AGEs affected immune homeostasis differentially and do so through modulating macrophage‐derived factors.Methods and resultsTwo systems (glycine‐glucose and whey protein isolate (WPI)‐glucose) are established to generate glycation products. They are applied to human macrophages (PMA‐differentiated U937 cells), and cell viability and cytokine production are measured. Furthermore, EGPs, AGEs, and their conditioned medium (CM) from macrophages are applied to human prostate cancer (PCa) cells with different etiology (LNCaP and PC‐3) and murine PCa cells (TRAMP‐C2) to determine their direct and indirect effects on PCa cell proliferation. EGPs enhance the production of immunosuppressive cytokines, and this enhancement is associated with increased PCa cell proliferation. In contrast, AGEs inhibit macrophages to secret cytokines, but increase PCa cell proliferation directly.ConclusionsOur data suggest that EGPs promote the prostate tumor proliferation indirectly through modulating macrophages, while AGEs have a direct effect.
Compressed sensing in quantitative determination of GAG concentration in cartilage by microscopic MRI
Authors: Wang Nian , Badar Farid , Xia Yang 
Published: October 2017

PurposeTo evaluate the potentials of compressed sensing (CS) in MRI quantification of glycosaminoglycan (GAG) concentration in articular cartilage at microscopic resolution.MethodsT1‐weighted 2D experiments of cartilage were fully sampled in k‐space with five inversion times at 17.6 μm resolution. These fully sampled k‐space data were re‐processed, by undersampling at various 1D and 2D CS undersampling factors (UFs). The undersampled data were reconstructed individually into 2D images using nonlinear reconstruction, which were used to calculate 2D maps of T1 and GAG concentration. The values of T1 and GAG in cartilage were evaluated at different UFs (up to 16, which used 6.25% of the data). K‐space sampling pattern and zonal variations were also investigated.ResultsUsing 2D variable density sampling pattern, the T1 images at UFs up to eight preserved major visual information and produced negligible artifacts. The GAG concentration remained accurate for different sub‐tissue zones at various UFs. The variation of the mean GAG concentration through the whole tissue depth was 1.20%, compared to the fully sampled results. The maximum variation was 2.24% in the deep zone of cartilage. Using 1D variable density sampling pattern, the quantitative T1 mapping and GAG concentration at UFs up to 4 showed negligible variations.ConclusionThis study demonstrates that CS could be beneficial in microscopic MRI (µMRI) studies of cartilage by acquiring less data, without losing significant accuracy in the quantification of GAG concentration. Magn Reson Med 79:3163–3171, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Internalizing Weight Stigma: Prevalence and Sociodemographic Considerations in US Adults
Authors: Puhl Rebecca M. , Himmelstein Mary S. , Quinn Diane M. 
Published: October 2017

ObjectiveThis study aimed to conduct a comprehensive assessment of the presence, severity, and sociodemographic correlates of weight bias internalization (WBI) across three distinct samples of US adults.MethodsLevels of WBI were compared in (1) a sample of adults with obesity and heightened risk of weight stigma (N = 456), (2) an online community sample (N = 519), and (3) a national online panel (N = 2,529). Samples 2 and 3 comprised adults with and without obesity. Participants completed identical self‐report measures, including demographic variables and weight‐related factors, to determine their relationship with low, mean, and high levels of WBI.ResultsAt least 44% of adults across samples endorsed mean levels of WBI (as determined by sample 3). The highest levels of WBI were endorsed by approximately one in five adults in the general population samples and by 52% in the sample of adults with obesity. Individuals with the highest WBI were white, had less education and income, were currently trying to lose weight, and had higher BMIs, higher self‐perceived weight, and previous experiences of weight stigma (especially teasing).ConclusionsInternalized weight bias is prevalent among women and men and across body weight categories. Findings provide a foundation to better understand characteristics of individuals who are at risk for internalizing weight bias.
Effect of miscibility on migration of third component in star‐like co‐continuous and disperse‐within‐disperse mixed brushes
Authors: Abbaspoor Saleheh , Agbolaghi Samira , Mahmoudi Mojgan , Jahanbani Yalda , Abbasi Farhang , Sarvari Raana 
Published: October 2017

AbstractNovel ternary mixed‐brush single crystals were designed with disperse‐within‐disperse and star‐like co‐continuous morphologies based on poly(ethylene glycol) (PEG)‐b‐polystyrene (PS)/PEG‐b‐poly(methyl methacrylate) (PMMA)/PEG‐b‐polyaniline (PANI) and PEG‐b‐PS/PEG‐b‐PMMA/PEG‐b‐(poly(ϵ‐caprolactone) (PCL) or poly(l‐lactide) (PLLA)) block copolymers, respectively. In the disperse‐within‐disperse ternary mixed brushes, PANI nanorods were dispersed within the matrix (PS)–dispersed (PMMA) amorphous brushes. The flexibility and rigidity of brushes mainly affected the ultimate morphology and arrangement of amorphous coiled brushes in the vicinity of PANI nanorods. In addition, the migration of PCL and PLLA crystallizable brushes was evident into PMMA phases dispersed in the PS matrix, leading to star‐like co‐continuous patterns of PCL and PLLA brushes. This phenomenon was related to the miscibility of crystallizable PCL and PLLA brushes with the PMMA phase. The migration of crystallizable PCL and PLLA brushes increased the size of PMMA domains in the star‐like co‐continuous patterns. Despite the larger osmotic pressure of PLLA brushes, their higher miscibility with PMMA chains reflected the greater PMMA dispersal and wider PLLA star‐like branches. © 2017 Society of Chemical Industry
The impact of conventional and nonconventional inhalants on children and adolescents
Authors: Nasr Samya Z. , Nasrallah Ali Ibrahim , Abdulghani Mariam , Sweet Stuart C. 
Published: October 2017

AbstractAimInhalant abuse in the adolescent population is a growing concern for care givers, communities, physicians, and medical providers. The aim of this article is to provide a review of the literature about this new challenge. In addition, it raises awareness about recent health policy rulings.MethodsReview of the literature was done.ResultsIn this review article, the prevalence of different modes of inhalant use and abuse in children and young adults and their potential health implications will be examined: Cigarettes, ENDS (E Cigarettes), Hookah, Marijuana, and Huffing. Additionally, marketing and advertising tactics will be reviewed to understand how they target this population. A review of current health policy recommendations from the FDA, American Thoracic Society, and the American Academy of Pediatrics will also be discussed.ConclusionThe rapid rise in e‐cigarette and hookah use in school aged children should trigger a call to action in the medical and public health communities. Health policy recommendations need to be made to reduce the level of adolescent substance abuse.
The nuclear DEK interactome supports multi‐functionality
Authors: Smith Eric A. , Krumpelbeck Eric F. , Jegga Anil G. , Prell Malte , Matrka Marie M. , Kappes Ferdinand , Greis Kenneth D. , Ali Abdullah M. , Meetei Amom R. , Wells Susanne I. 
Published: October 2017

AbstractDEK is an oncoprotein that is overexpressed in many forms of cancer and participates in numerous cellular pathways. Of these different pathways, relevant interacting partners and functions of DEK are well described in regard to the regulation of chromatin structure, epigenetic marks, and transcription. Most of this understanding was derived by investigating DNA‐binding and chromatin processing capabilities of the oncoprotein. To facilitate the generation of mechanism‐driven hypotheses regarding DEK activities in underexplored areas, we have developed the first DEK interactome model using tandem‐affinity purification and mass spectrometry. With this approach, we identify IMPDH2, DDX21, and RPL7a as novel DEK binding partners, hinting at new roles for the oncogene in de novo nucleotide biosynthesis and ribosome formation. Additionally, a hydroxyurea‐specific interaction with replication protein A (RPA) was observed, suggesting that a DEK‐RPA complex may form in response to DNA replication fork stalling. Taken together, these findings highlight diverse activities for DEK across cellular pathways and support a model wherein this molecule performs a plethora of functions.
New theoretically predicted RDX‐ and β‐HMX‐based high‐energy‐density molecules
Authors: Jeong Keunhong 
Published: October 2017

AbstractTheoretically new high‐energy‐density materials (HEDM) in which the hydrogens on RDX and β‐HMX (hexahydro‐1,3,5‐trinitro‐1,3,5‐triazine and octahydro‐1,3,5,7‐tetranitro‐1,3,5,7‐tetrazocine, respectively) were sequentially replaced by (NNO2)x functional groups were designed and evaluated using density functional theory calculations in combination with the Kamlet–Jacobs equations and an atoms‐in‐molecules (AIM) analysis. Improved detonation properties and reduced sensitivity compared to RDX and β‐HMX were predicted. Interestingly, the RDX and β‐HMX derivatives having one attached NNO2 group [RDX‐(NNO2)1 and HMX‐(NNO2)1] showed excellent detonation properties (detonation velocities: 9.529 and 9.575 km·s−1, and detonation pressures: 40.818 and 41.570 GPa, respectively), which were superior to the parent compounds. Sensitivity estimations obtained by calculating impact sensitivities and HOMO‐LUMO gaps indicated that RDX‐(NNO2)1 and HMX‐(NNO2)1 were less stable than RDX and HMX but more stable than any of the other derivatives. This method of sequential NNO2 group attachment on conventional HEDMs offers a firm basis for further studies on the design of new explosives. Furthermore, the newly found structures may be promising candidates for better HEDMs.
Distance‐based control of formations with hybrid communication topology
Authors: Hou Yun , Yu Changbin 
Published: October 2017

SummaryIn this paper, we focus on the control of multiagent formations with hybrid communication topology through a distance‐based approach. By saying hybrid topology, we mean that the communication topology contains both undirected and directed links, or the underlying graph of the formation contains both undirected and directed edges. A new type of graph, ie, hybrid graph, is introduced. We discuss the persistence of hybrid graphs and present the persistence verification strategy for hybrid graphs. It is proved that all the minimally persistent hybrid graphs can be obtained from persistent directed graphs by the operation of edge transformation. As the main result, it is shown that multiagent formations modeled by acyclic persistent hybrid graphs can be stabilized locally under distance‐based controllers.
Performance analysis of 2‐DOF tracking control for a class of nonlinear uncertain systems with discontinuous disturbances
Authors: Xue Wenchao , Huang Yi 
Published: October 2017

SummaryIn this paper, the tracking control problem is considered for a class of uncertain nonlinear systems with infinite discontinuous points in the external disturbance. The extended state observer–based 2‐degree‐of‐freedom control is used with one degree to estimate and cancel the “total disturbance” and the other to force the closed‐loop system to have desired characteristics. The tracking error between the state vector and its ideal trajectory in the entire transient process is adequately discussed to illuminate the performance of resulting control systems. The quantitative analysis shows that the tracking error can be small enough by tuning the bandwidth of the extended state observer. Moreover, the necessary and sufficient condition for the tracking error and the estimation error of the “total disturbance” to converge to zero is presented. The simulation results of a motion test demonstrate that the desired performance of the control system can be achieved despite discontinuous disturbance and nonlinear uncertainties.
Adaptive output‐feedback Lyapunov‐based model predictive control of nonlinear process systems
Authors: Das Buddhadeva , Mhaskar Prashant 
Published: October 2017

SummaryThis work addresses the problem of output feedack control of nonlinear uncertain systems via adaptive Lyapunov‐based model predictive control design. To this end, at every control implementation, a moving horizon mechanism is first utilized to generate current estimates of the uncertainty and states. The model with the current estimated uncertainty is then used in a Lyapunov‐based model predictive controller to achieve uncertainty rejection. The key ideas are explained through an illustrative example and the application demonstrated on a networked reactor‐separator process subject to measurement noise and uncertainty.
Stability analysis of time‐delay systems via Bessel inequality: A quadratic separation approach
Authors: Ariba Yassine , Gouaisbaut Frédéric , Seuret Alexandre , Peaucelle Dimitri 
Published: October 2017

SummaryIn this paper, new sufficient stability conditions for the asymptotic stability of time‐delay systems are presented using the quadratic separation approach. The time‐delay system is modeled as an interconnected closed‐loop system involving a linear transformation and delay‐dependent functions, representing the uncertainties brought by the delay. Those complex‐valued functions are then embedded into adequate norm‐bounded uncertainties, which lead to several stability results. The novelty of this approach relies on the introduction of new dedicated functions that are built in accordance to the Bessel inequality. They allow us to model the system as an uncertain feedback system and to control the accuracy of the inequality. Then, a sequence of linear matrix inequality conditions is proposed, which tends to the analytical bounds for both delay‐dependent stability and delay range stability, at least on examples.
How to avoid small results with big data
Authors: Joshi Amit 
Published: October 2017

Big data and analytics are buzzwords that elicit both excitement and fear in managers in most firms, small or large. Firms are competing with each other to implement their data and analytics strategies, in the process spending billions of dollars, either to cement their leadership position or play catch‐up with their closest competitors. According to a recent report by the International Data Corporation, the big data and business analytics (BDA) market is expected to generate a revenue of $150 billion in 2017.Moreover, this industry is predicted to grow at over 12% annually, crossing the $200 billion mark by 2020.
Does stress mediate the association between personal relative deprivation and gambling?
Authors: Mishra Sandeep , Meadows Tyler J. S. 
Published: October 2017

AbstractEvidence has linked subjective feelings of personal relative deprivation with general gambling involvement and problem gambling tendencies. In turn, problem gambling tendencies have been linked with a wide array of damaging physical and mental health consequences. It has been theorized that the deleterious effects of perceived inequality on mental and physical health operate at the individual level through the experience of personal relative deprivation leading to psychosocial stress. We empirically examined whether the experience of perceived stress contributes to explaining the deprivation‐gambling link using cross‐sectional, self‐reported survey data collected from a crowdsourced population of adults (n = 565). Results indicate that personal relative deprivation is associated with problem gambling tendencies (but not general gambling involvement) and that this association is mediated by perceived stress. These associations were particularly strong among participants who reported non‐zero levels of problem gambling tendencies. Together, our results further emphasize the importance of individual‐level social comparison reactions in the context of health.
Reading the Past to Inform the Future: 25 Years of The Reading Teacher
Authors: Mohr Kathleen A.J. , Ding Guoqin , Strong Ashley , Branum Lezlie , Watson Nanette , Priestley K. Lea , Juth Stephanie , Carpenter Neil , Lundstrom Kacy 
Published: October 2017

AbstractThis analysis examines articles from the past 25 years of The Reading Teacher to better understand the journal's content and trends influencing literacy instruction. A research team coded and analyzed the frequency of topics and grade levels targeted, then compared results with those of a similar analysis published in 1992. The Web of Science provided current information about trends in authorship and the popularity of highly cited and frequently accessed articles. This report shares various metrics, insights, and interpretations that help profile the impact of The Reading Teacher and make predictions about the future of reading instruction.
Developing English Learners’ Reading Confidence With Whole‐Class Repeated Reading
Authors: Monobe Gumiko , Bintz William P. , McTeer Janis S. 
Published: October 2017

AbstractThis Teaching Tip describes how one second‐grade teacher used whole‐class repeated reading (WCRR) to promote social interaction and develop reading confidence with English learners (ELs). The authors share a brief review of professional literature on the challenges of ELs and the benefits of repeated reading and WCRR. The authors also provide instructional recommendations for teachers interested in using WCRR in the classroom: prepare intentionally and implement systematically, select texts thoughtfully and sensitively, promote active engagement, support public performance and family involvement, and support reading growth and development. The authors end with final thoughts about how WCRR can help create an inclusive classroom and ultimately help all students, particularly ELs, learn together in an active, meaningful, and enjoyable environment.
Context‐aware movement analytics: implications, taxonomy, and design framework
Authors: Sharif Mohammad , Alesheikh Ali Asghar 
Published: October 2017

Movement of an entity is greatly affected by its internal and external contexts. Such consequential influence has created new paradigms for context‐aware movement data mining and analysis. The significance of incorporating contextual information and movement data is becoming quite evident because of the growing interest in context‐aware movement analysis. Despite such importance, there is limited consensus among researchers on the definition of context and context‐aware system design in movement studies. Therefore, this paper comprehensively reviews current concepts of context and provides a definition and a taxonomy for context in movement analysis. The paper proceeds by providing a definition of context‐aware systems in the movement area after a complete review and comparison of the present definitions present in the literature. Inspired by related works, the paper further suggests a holistic three‐layer design framework tailored to context‐aware systems in movement studies to examine in greater depth the techniques applied during the design stages. The paper outlines the challenges and emergent issues in future research directions in context‐aware movement analysis. The present study is an attempt to bridge the gap between solely using context and developing context‐aware systems, thus paving the way for further research in movement applications. WIREs Data Mining Knowl Discov 2018, 8:e1233. doi: 10.1002/widm.1233This article is categorized under:

Fundamental Concepts of Data and Knowledge > Data Concepts
Fundamental Concepts of Data and Knowledge > Human Centricity and User Interaction
Fundamental Concepts of Data and Knowledge > Key Design Issues in Data Mining