bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between chronic kidney disease with diabetes or hypertension and frailty in community‐dwelling Japanese older adults
Authors: Lee Sungchul , Lee Sangyoon , Harada Kazuhiro , Bae Seongryu , Makizako Hyuma , Doi Takehiko , Tsutsumimoto Kota , Hotta Ryo , Nakakubo Sho , Park Hyuntae , Suzuki Takao , Shimada Hiroyuki 
Published: September 2016

AimThe aim of the present study was to evaluate the relationship between kidney function with concomitant diabetes or hypertension and frailty in community‐dwelling Japanese older adults.MethodsThe participants were 9606 residents (community‐dwelling Japanese older adults) who completed baseline assessments. The estimated glomerular filtration rate (mL/min/1.73 m2) was determined according to the serum creatinine level, and participants were classified into four mutually exclusive categories: ≥60.0 (normal range), 45.0–59.9, 30.0–44.9 and <30.0 mL/min/1.73 m2. Frailty status was defined using five criteria as described by Fried: slow gait speed, muscle weakness, low physical activity, exhaustion and unintentional weight loss. Participants who met three, four or five criteria satisfied the definition of having frailty. Multivariate logistic regression was used to examine the relationships between estimated glomerular filtration rate and frailty.ResultsAfter multivariate adjustment, participants with lower kidney function (estimated glomerular filtration rate <30.0 mL/min/1.73 m2) were more frail (odds ratio [OR] 1.90, 95% confidence interval [CI] 1.01−3.59). In addition, individuals with a history of diabetes (OR 2.76, 95% CI 1.21−8.24) or hypertension (OR 2.53, 95% CI 1.45−5.12) showed a significantly increased risk of frailty in the lower kidney function group, regardless of multivariate controls. Furthermore, the analyses showed an even greater increase in the risk of frailty in patients with a history of both diabetes and hypertension (OR 3.67, 95% CI 1.13−14.1)ConclusionsA lower level of kidney function was associated with a higher risk of frailty in community‐dwelling Japanese older adults. Geriatr Gerontol Int 2017; 17: 1527–1533.
Three cases of spontaneous lumbar artery rupture in hemodialysis patients
Authors: Hwang Na Kyoung , Rhee Harin , Kim Il Young , Seong Eun Young , Lee Dong Won , Lee Soo Bong , Kwak Ihm Soo , Kim Chang Won , Song Sang Heon 
Published: September 2016

AbstractWe encountered three cases of retroperitoneal hematoma caused by spontaneous lumbar artery rupture, a rare vascular complication. At the time of retroperitoneal hematoma, two patients were on anticoagulant/antiplatelet therapy. One patient was not taking any anticoagulant/antiplatelet agents but was receiving hemodialysis treatment with heparin. Lumbar artery rupture was successfully controlled by transcatheter arterial embolization in all patients, but one patient developed multiple organ failure and died. We suggest that spontaneous lumbar artery rupture may occur in patients being treated with maintenance hemodialysis or anticoagulant/antiplatelet therapy. Therefore, clinicians should suspect lumbar artery rupture in patients with unstable vital signs and rapid onset of anemia because early diagnosis and appropriate intervention are necessary to decrease the risks of morbidity and mortality.
Impact of serum and dialysates obtained from chronic hemodialysis patients maintained on high cut‐off membranes on inflammation profile in human THP‐1 monocytes
Authors: Trojanowicz Bogusz , Ulrich Christof , Fiedler Roman , Storr Markus , Boehler Torsten , Martus Peter , Pawlak Michael , Glomb Marcus A. , Henning Christian , Templin Markus , Werner Kristin , Zickler Daniel , Willy Kevin , Schindler Ralf , Girndt Matthias 
Published: September 2016

AbstractIntroduction: Patients with chronic kidney disease maintained on intermittent hemodialysis suffer from systemic chronic inflammation which is causally associated with high mortality. Inflammation mediators of 15–45 kDa range cannot be effectively removed by conventional dialysis membranes. In this study, we tested the influence of serum and dialysates obtained from patients maintained on High cut‐off or High flux membranes on the inflammation profile of THP‐1 monocytes.Methods: THP‐1 monocytes were treated with serum or dialysates obtained from patients maintained on High cut‐off and High flux membranes within a randomized crossover pilot trial. Serum‐treated cells were subjected to qPCR analyses with TaqMan probes specific for IL6, TNFa, osteopontin and osteocalcin, and transcriptional screening with Inflammatory Array. Apoptosis assay was performed flow cytometrically with 7‐AAD and Annexin V staining.Findings: Treatment of the cells with High cut‐off serum led to significant reduction of TNFa and IL‐6 expression as well as inflammation‐related osteopontin and osteocalcin as compared to High flux membrane treatment. As a complementary finding, treatment with High cut‐off dialysates induced a pro‐apoptotic phenotype in the cells as demonstrated by a significantly increased percentage of 7‐AAD and Annexin V positivity. Global screening of serum‐treated cells revealed noticeably decreased inflammation profile under High cut‐off serum as compared to High flux treatment.Discussion: Taken together, these data demonstrate that High cut‐off ‐membranes eliminate a spectrum of mediators from serum into the dialysate that possess proinflammatory properties and may impair cellular viability.
Bone morphogenetic protein‐4 modulates proliferation and terminal differentiation of fetal hepatic stem/progenitor cells
Authors: Goto Fumio , Kakinuma Sei , Miyoshi Masato , Tsunoda Tomoyuki , Kaneko Shun , Sato Ayako , Asano Yu , Otani Satoshi , Azuma Seishin , Nagata Hiroko , Kawai‐Kitahata Fukiko , Murakawa Miyako , Nitta Sayuri , Itsui Yasuhiro , Nakagawa Mina , Asahina Yasuhiro , Watanabe Mamoru 
Published: September 2016

AimFetal hepatic stem/progenitor cells, called hepatoblasts, play central roles in liver organogenesis; however, molecular mechanisms regulating proliferation and terminal differentiation of such cells have not been completely elucidated. Bone morphogenetic protein‐4 (BMP‐4) is essential for the development of stem cells in various tissues, but its function in regulating the phenotype of hepatoblasts after the mid‐gestational fetal stage remains unclear. The aim of this study is to clarify a functional role for BMP‐4 in proliferation and terminal differentiation of murine hepatoblasts in mid‐gestational fetal livers.MethodsA functional role for BMP‐4 in proliferation and terminal differentiation of murine hepatoblasts was validated by assay of colony formation, biliary luminal formation, and hepatic maturation using primary hepatoblasts in vitro. Molecular mechanisms regulating such effects of BMP‐4 on primary hepatoblasts were also analyzed.ResultsStimulation of BMP‐4 upregulated phosphorylation of Smad1/5 in hepatoblasts. Bone morphogenetic protein‐4 significantly suppressed colony formation of primary hepatoblasts in a dose‐dependent manner, significantly suppressed cholangiocytic luminal formation of hepatoblasts, and promoted hepatic maturation of primary hepatoblasts. Stimulation of BMP‐4 regulated the activation of several mitogen‐activated protein kinases, such as extracellular signal‐regulated kinase, Akt, p38 mitogen‐activated protein kinase, and calcium/calmodulin‐dependent protein kinase IIα in primary hepatoblasts. Moreover, Wnt5a, a molecule regulating cholangiocytic luminal formation, and BMP‐4 coordinately suppressed proliferation and cholangiocytic luminal formation of hepatoblasts.ConclusionThis study shows that BMP‐4‐mediated signaling controls proliferation and terminal differentiation of fetal hepatic stem/progenitor cells.
Keeping all options open: Parents’ approaches to advance care planning
Authors: Beecham Emma , Oostendorp Linda , Crocker Joanna , Kelly Paula , Dinsdale Andrew , Hemsley June , Russell Jessica , Jones Louise , Bluebond‐Langner Myra 
Published: September 2016

AbstractBackgroundEarly engagement in advance care planning (ACP) is seen as fundamental for ensuring the highest standard of care for children and young people with a life‐limiting condition (LLC). However, most families have little knowledge or experience of ACP.ObjectiveTo investigate how parents of children and young people with LLCs approach and experience ACP.MethodsOpen‐ended, semi‐structured interviews were conducted with parents of 18 children; nine children who were currently receiving palliative care services, and nine children who had received palliative care and died. Verbatim transcripts of audiotaped interviews were analysed following principles of grounded theory while acknowledging the use of deductive strategies, taking account of both the child's condition, and the timing and nature of decisions made.ResultsParents reported having discussions and making decisions about the place of care, place of death and the limitation of treatment. Most decisions were made relatively late in the illness and by parents who wished to keep their options open. Parents reported different levels of involvement in a range of decisions; many wished to be involved in decision making but did not always feel able to do so.DiscussionThis study highlights that parents’ approaches to decision making vary by the type of decision required. Their views may change over time, and it is important to allow them to keep their options open. We recommend that clinicians have regular discussions over the course of the illness in an effort to understand parents’ approaches to particular decisions rather than to drive to closure prematurely.
Dynamique industrie‐services et développement économique
Authors: KUCERA David , RONCOLATO Leanne 
Published: September 2016

RésuméLe rôle des services dans la croissance fait débat chez les économistes, qui y voient tantôt un substitut, tantôt un complément de l'industrie. Après un rappel des études empiriques sur la question, les auteurs décomposent la croissance dans dix‐huit pays d'Asie et d'Amérique latine pour la période 1980–2005, en mettant l'accent sur les activités qui reposent sur les technologies de l'information et de la communication. Ils recherchent ensuite les caractéristiques structurelles communes aux pays les plus performants et les moins performants en matière d'emploi et de productivité du travail et s'interrogent sur la viabilité de la croissance axée sur les services, en Inde notamment.
L'intensité d'emploi de la croissance en Tunisie, selon le secteur et dans une perspective à long terme
Authors: SASSI Seifallah , GOAIED Mohamed 
Published: September 2016

RésuméLes auteurs examinent le potentiel de création d'emplois des secteurs d'activité tunisiens sur le long terme. Ils estiment l'élasticité production‐emploi de long terme à partir de données de panel portant sur quinze secteurs et sur la période 1983–2010, en utilisant un estimateur de type MG (moyenne de groupe). L'analyse montre que les industries extractives ne peuvent pas absorber de main‐d'œuvre, et que le développement de l'hôtellerie‐restauration se fait sans création d'emplois sur le long terme. Les auteurs préconisent en conséquence d'axer la politique économique sur les secteurs particulièrement intensifs en main‐d'œuvre – services et industries manufacturières d'exportation – et sur les activités paratouristiques plutôt que touristiques.
Mesurer la vulnérabilité au travail en Europe
Authors: BAZILLIER Rémi , BOBOC Cristina , CALAVREZO Oana 
Published: September 2016

RésuméLa progression des formes de travail atypiques et l'augmentation du nombre d'emplois occupés au cours d'une vie professionnelle sont deux tendances marquantes de l'évolution du marché du travail en Europe. Après un tour d'horizon des perspectives sur la question, dont celle de l'OIT, les auteurs s'appliquent à mesurer cette nouvelle «vulnérabilité au travail» en s'appuyant sur une analyse des correspondances multiples et des données de l'Enquête sociale européenne de 2008. Ils proposent ainsi deux indicateurs inédits, un indice de la vulnérabilité liée à l'employeur et un indice de la vulnérabilité liée au poste, qui constituent pris ensemble un indice global de vulnérabilité au travail.
Induction of mucosal immune responses against Helicobacter pylori infection after sublingual and intragastric route of immunization
Authors: Sjökvist Ottsjö Louise , Jeverstam Frida , Yrlid Linda , Wenzel Alexander U. , Walduck Anna K. , Raghavan Sukanya 
Published: September 2016

SummaryThere is a current lack of effective mucosal vaccines against major gastroenteric pathogens and particularly against Helicobacter pylori, which causes a chronic infection that can lead to peptic ulcers and gastric cancer in a subpopulation of infected individuals. Mucosal CD4+ T‐cell responses have been shown to be essential for vaccine‐induced protection against H. pylori infection. The current study addresses the influence of the adjuvant and site of mucosal immunization on early CD4+ T‐cell priming to H. pylori antigens. The vaccine formulation consisted of H. pylori lysate antigens and mucosal adjuvants, cholera toxin (CT) or a detoxified double‐mutant heat‐labile enterotoxin from Escherichia coli (dmLT), which were administered by either the sublingual or intragastric route. We report that in vitro, adjuvants CT and dmLT induce up‐regulation of pro‐inflammatory gene expression in purified dendritic cells and enhance the H. pylori‐specific CD4+ T‐cell response including interleukin‐17A (IL‐17A), interferon‐γ (IFN‐γ) and tumour necrosis factor‐α (TNF‐α) secretion. In vivo, sublingual immunization led to an increased frequency of IL‐17A+, IFN‐γ+ and TNF‐α+ secreting CD4+ T cells in the cervical lymph nodes compared with in the mesenteric lymph nodes after intragastric immunization. Subsequently, IL‐17A+ cells were visualized in the stomach of sublingually immunized and challenged mice. In summary, our results suggest that addition of an adjuvant to the vaccine clearly activated dendritic cells, which in turn, enhanced CD4+ T‐cell cytokines IL‐17A, IFN‐γ and TNF‐α responses, particularly in the cervical lymph nodes after sublingual vaccination.
Predicting sleep hygiene: a reasoned action approach
Authors: Tagler Michael J. , Stanko Kathleen A. , Forbey Johnathan D. 
Published: September 2016

AbstractPoor and insufficient sleep causes physical, cognitive, emotional, and social impairments. Unfortunately, little is known about the social‐cognitive predictors of daily sleep habits. The current study examined if sleep hygiene could be predicted using the Reasoned Action Model (Fishbein & Ajzen, ). Across four studies, the model performed well for the prediction of intentions (R2s = .63–.75), and also significantly predicted both self‐reported (R2 = .15) and actigraphy‐recorded sleep duration (R2 = .11). The results from these studies support the further use of the model toward the goal of designing effective sleep hygiene interventions.
Home‐Based Exercise Supported by General Practitioner Practices: Ineffective in a Sample of Chronically Ill, Mobility‐Limited Older Adults (the HOMEfit Randomized Controlled Trial)
Authors: Hinrichs Timo , Bücker Bettina , Klaaßen‐Mielke Renate , Brach Michael , Wilm Stefan , Platen Petra , Mai Anna 
Published: September 2016

ObjectivesTo evaluate the effects a home‐based exercise program delivered to ill and mobility‐limited elderly individuals on physical function, physical activity, quality of life, fall‐related self‐efficacy, and exercise self‐efficacy.DesignRandomized controlled trial (ISRCTN Registry, Reg.‐No. ISRCTN17727272).SettingFifteen general practitioner (GP) practices and participants' homes.ParticipantsChronically ill and mobility‐limited individuals aged 70 and older (N = 209).InterventionsAn exercise therapist delivered the experimental intervention—a 12‐week multidimensional home‐based exercise program integrating behavioral strategies—in individual counseling sessions at the GPs' practices and over the telephone. The control intervention focused on promoting light‐intensity activities of daily living. Interventions took place between February 2012 and March 2013.MeasurementsThe primary outcome was functional lower body strength (chair‐rise test). Secondary outcomes were physical function (battery of motor tests), physical activity (step count), health‐related quality of life (Medical Outcomes Study 8‐item Short‐Form Survey), fall‐related (Falls Efficacy Scale—International Version), and exercise self‐efficacy (Selbstwirksamkeit zur sportlichen Aktivitaet (SSA) scale). Postintervention differences between the groups were tested using analysis of covariance (intention to treat; adjusted for baseline value and GP practice; significance level P ≤ .05).ResultsParticipants had a mean age ± standard deviation of 80 ± 5, 74% were female, 87% had three or more chronic diseases, and 54% used a walking aid. The difference (intention to treat; experimental minus control) between adjusted postintervention chair‐rise times was −0.1 (95% confidence interval = −1.8–1.7). Differences for all secondary outcomes were also nonsignificant.ConclusionThe program was ineffective in the target population. Possibilities for improving the concept will have to be evaluated.
Association Between Social Participation and 3‐Year Change in Instrumental Activities of Daily Living in Community‐Dwelling Elderly Adults
Authors: Tomioka Kimiko , Kurumatani Norio , Hosoi Hiroshi 
Published: September 2016

ObjectivesTo investigate whether social participation (SP) in older adults is associated with ability to perform instrumental activities of daily living (IADLs).DesignProspective cohort study.SettingTwo local municipalities of Nara, Japan.ParticipantsIndividuals aged 65 to 96 (n = 2,774 male, n = 3,586 female) free of IADL disability at baseline.MeasurementsSP and IADLs were assessed using self‐administered questionnaires. SP was categorized into five types and assessed using the number and type of social activities. IADLs were evaluated using the Tokyo Metropolitan Institute of Gerontology Index of Competence. Logistic regression analysis stratified according to sex was used to examine change in IADLs according to SP, with nonparticipation as a reference.ResultsDuring the 3‐year follow‐up, 13.6% of men and 9.0% of women reported IADL decline. After adjusting for age, family structure, body mass index, pension, occupation, medical treatment, self‐rated health, drinking, smoking, depression, cognitive function, and activities of daily living, participation in various social activities was inversely associated with change in IADLs in women but not men. Participation in the following types of social activities had significant inverse associations with IADL disability: hobby clubs (odds ratio (OR) = 0.68, 95% confidence interval (CI) = 0.49–0.94) for men and local events (OR = 0.68, 95% CI = 0.48–0.95), hobby clubs (OR = 0.53, 95% CI = 0.36–0.79), senior citizen clubs (OR = 0.74, 95% CI = 0.56–0.97), and volunteer groups (OR = 0.56, 95% CI = 0.32–0.99) for women.ConclusionParticipation in a variety of different types of social activities was associated with change in IADLs over the 3 years of this study in women, and participation in hobby clubs was associated with change in IADLs in men and women. Recommending that community‐dwelling elderly adults participate in social activities appropriate for their sex may promote successful aging.
Comparison of The Canary System and DIAGNOdent for the in vitro detection of caries under opaque dental sealants
Authors: Silvertown Josh D. , Wong Bonny P. Y. , Abrams Stephen H. , Sivagurunathan Koneswaran S. , Mathews Sapna M. , Amaechi Bennett T. 
Published: September 2016

AbstractAimThe aim of the present study was to investigate the ability of operators using The Canary System and DIAGNOdent to detect natural pit and fissure caries under four commonly‐used opaque dental sealants.MethodsMixed sound and carious pits/fissures (N = 105) selected from 40 human teeth were randomly assigned (10 teeth/group) to one of four opaque sealant groups (Delton, Embrace WetBond, Helioseal F, UltraSeal XT Plus). Selected pits/fissures sites on occlusal surfaces were scanned with The Canary System and DIAGNOdent, sealed, re‐scanned, and subjected to polarized light microscopy to confirm whether the scanned regions were sound or carious. Sensitivities and specificities for each detection method before and after sealant placement were calculated.ResultsThe Canary System and DIAGNOdent were able to distinguish between sound and carious tissue beneath opaque sealants with an accuracy of 76% and 59%, respectively.ConclusionsThe Canary System can serve as a clinical tool to aid dental professionals to detect and monitor the status of caries lesions and tooth structure underneath sealant. The increased likelihood of false‐positive diagnoses with DIAGNOdent due to intrinsic auto‐fluorescence of sealant filler and opacifying agents might limit its usefulness as an aid to detect caries underneath opaque sealants.
Gender Asymmetry in Educational and Income Assortative Marriage
Authors: Qian Yue 
Published: September 2016

AbstractThe reversal of the gender gap in education has reshaped the U.S. marriage market. Drawing on data from the 1980 U.S. Census and the 2008–2012 American Community Surveys, the author used log‐linear models to examine gender asymmetry in educational and income assortative mating among newlyweds. Between 1980 and 2008–2012, educational assortative mating reversed from a tendency for women to marry up to a tendency for women to marry down in education, whereas the tendency for women to marry men with higher incomes than themselves persisted. Moreover, in both time periods, the tendency for women to marry up in income was generally greater among couples in which the wife's education level equaled or surpassed that of the husband than among couples in which the wife was less educated than the husband. The author discusses the implications of the rising female advantage in education for gender change in heterosexual marriages.
Psychological Well‐being Among Older Adults: The Role of Partnership Status
Authors: Wright Matthew R. , Brown Susan L. 
Published: September 2016

AbstractToday's older adults are increasingly unmarried. Some are in cohabiting unions, others are dating, and many remain unpartnered. Unmarried older adults are at risk of poorer well‐being than married older adults, but it is unclear whether older cohabitors fare worse than or similar to their married counterparts; nor have well‐being differences among cohabitors, daters, and unpartnered persons been considered. Conceptualizing marital status as a continuum of social attachment, data from Waves I and II of the National Social Life, Health, and Aging Project are used to examine how older married, cohabiting, dating, and unpartnered individuals differ across multiple indicators of psychological well‐being. Among men, cohabitors appear to fare similarly to the married, and better than daters and the unpartnered. In contrast, there are few differences in psychological well‐being by partnership status for women.