bluuebunny/crossref_metadata_2025_split huggingface dataset:
Angle comparison using an autocollimator
Authors: Geckeler Ralf D , Just Andreas , Vasilev Valentin , Prieto Emilio , Dvorácek František , Zelenika Slobodan , Przybylska Joanna , Duta Alexandru , Victorov Ilya , Pisani Marco , Saraiva Fernanda , Salgado Jose-Antonio , Gao Sitian , Anusorn Tonmueanwai , Tan Siew Leng , Cox Peter , Watanabe Tsukasa , Lewis Andrew , Chaudhary K P , Thalmann Ruedi , Banreti Edit , Nurul Alfiyati , Fira Roman , Yandayan Tanfer , Chekirda Konstantin , Bergmans Rob , Lassila Antti 
Published: January 2018

Autocollimators are versatile optical devices for the contactless measurement of the tilt angles of reflecting surfaces. An international key comparison (KC) on autocollimator calibration, EURAMET.L-K3.2009, was initiated by the European Association of National Metrology Institutes (EURAMET) to provide information on the capabilities in this field. The Physikalisch-Technische Bundesanstalt (PTB) acted as the pilot laboratory, with a total of 25 international participants from EURAMET and from the Asia Pacific Metrology Programme (APMP) providing measurements. This KC was the first one to utilise a high-resolution electronic autocollimator as a standard. In contrast to KCs in angle metrology which usually involve the full plane angle, it focused on relatively small angular ranges (±10 arcsec and ±1000 arcsec) and step sizes (10 arcsec and 0.1 arcsec, respectively). This document represents the approved final report on the results of the KC.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCL, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Association between polycystic ovary syndrome and hot flash presentation during the midlife period
Authors: Yin Ophelia , Zacur Howard A. , Flaws Jodi A. , Christianson Mindy S. 
Published: January 2018

Abstract

Objective:
Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in reproductive-aged women; however, the impact of PCOS on menopausal symptoms remains poorly understood. This study aims to determine the influence of PCOS on hot flash presentation in midlife women.

Methods:
Participants were recruited from the Midlife Women's Health Study involving 780 women aged 45 to 54 years. All women completed detailed questionnaires on hot flash symptoms. Between June 2014 and March 2015, participants were screened for history of PCOS based on the Rotterdam criteria. Fisher's exact tests and Wilcoxon rank-sum tests were used for analysis. Multivariate logistic regression was performed to identify factors associated with hot flashes at midlife.

Results:
In all, 453 women (69%) consented to the telephone interview and 9.3% (n = 42) met diagnostic criteria for PCOS; 411 were included as controls. Mean age was 48.0 and body mass index was 27.3 for women with PCOS. The majority of participants were white (72%). There was no difference between PCOS and control women for levels of follicle-stimulating hormone, testosterone, progesterone, or estradiol. Multivariate logistic regression demonstrated that PCOS was not associated with increased odds of hot flash incidence. Smoking was the only variable associated with experiencing hot flashes (odds ratio 2.0, 95% confidence interval 1.05-3.98).

Conclusions:
A history of PCOS was not associated with increased hot flash symptoms during the midlife period. Additional research should continue to investigate the health and quality of life associated with a history of PCOS in the aging population.
Temporal Fluctuations in Indoor Background Gamma Radiation Using NaI(Tl)
Authors: Smith Travis , Cao Sana , Kearfott Kimberlee J. 
Published: January 2018

Abstract
An enhanced understanding of background gamma radiation is necessary for accurate radionuclide activity quantification. Background spectra are routinely subtracted from spectra of samples prepared in known geometries, with data collection time chosen to optimize statistics for counting uncertainties. The work presents measured background spectra collected inside and outside shields of varying geometry and composition, showing the effects of these on background. Gamma background measurements with and without blank samples are included along with spectra from different sizes and shapes of NaI(Tl) detectors. If the environment is being monitored for quick and confident detection of recently appearing radiation sources, a thorough knowledge of the background radiation and its temporal variation is essential. To study the requirements of such background measurements, sequential background gamma radiation collections were obtained on an hourly basis for a total of 316 h from an unshielded 5.5 × 11 × 40 cm3 NaI(Tl) detector located inside a laboratory setting where small sources are routinely stored and used. Finally, a strategy for optimizing data collection times and analyzing background gamma radiation spectra for long-term radionuclide monitoring is presented.
DIRECTIONAL VARIABILITY OF FUNDUS REFLECTANCE IN ACUTE MACULAR NEURORETINOPATHY: EVIDENCE FOR A CONTRIBUTION OF THE STILES–CRAWFORD EFFECT
Authors: Bottin Caroline , Grieve Kate , Rossant Florence , Pedinielli Alexandre , Mrejen Sarah , Paques Michel 
Published: January 2018

Purpose:
To document directional reflectivity of fundus lesions in a case of acute macular neuroretinopathy.

Methods:
Case report. Clinical and imaging data from a patient with acute macular neuroretinopathy were reviewed. Imaging comprised infrared scanning laser ophthalmoscopy, optical coherence tomography and flood-illumination adaptive optics images acquired through different entry pupils in the cardinal directions (approximately 2° eccentricity).

Results:
The patient reported acute bilateral paracentral scotoma revealing dark, wedge-shaped macular plaques which by optical coherence tomography were associated with focal loss of the visibility of the cone outer segment tip and inner/outer segment lines. Comparing scanning laser ophthalmoscopy images taken at different entry points in the pupil showed that macular plaques varied from hyporeflectance to isoreflectance. Cone counts by flood-illumination adaptive optics within plaques and optical coherence tomography features of the cone outer segment tip showed also a strong directional variability, peaking at near-normal values. Within each modality, fusion images showed that directional variability covered most of macular plaques.

Conclusion:
The characteristic fundus abnormalities of acute macular neuroretinopathy may show a strong directional variability. Our findings suggest that the Stiles–Crawford effect may be an important factor in signs and symptoms of acute macular neuroretinopathy.
In Vitro Evaluation of a Hypochlorous Acid Hygiene Solution on Established Biofilms
Authors: Romanowski Eric G. , Stella Nicholas A. , Yates Kathleen A. , Brothers Kimberly M. , Kowalski Regis P. , Shanks Robert M. Q. 
Published: January 2018

Objectives:
The purpose of this study was to determine whether a commercial formulation of hypochlorous acid hygiene solution (0.01%), Avenova, can destroy existing biofilms formed by ocular clinical bacterial isolates, including blepharitis isolates of Staphylococcus aureus and coagulase-negative staphylococci, and a keratitis isolate of Pseudomonas aeruginosa.

Methods:
Biofilms grown in bacterial growth media on disposable contact lens cases were challenged with hypochlorous acid hygiene solution. At various time points, surviving bacteria were quantified by serial dilution and colony counts. Staphylococcus aureus biofilms formed on glass were challenged using a hypochlorous acid hygiene solution and imaged using vital staining and confocal laser scanning microscopy.

Results:
Bactericidal activity (≥3 Log10; 99.9%) was observed for all tested bacterial species after a 30-min exposure. Staphylococcus aureus biofilms had a bactericidal level of killing by 10 min (P<0.01), Staphylococcus capitis by 5 min (P<0.001), Staphylococcus epidermidis by 30 min (P<0.001), and P. aeruginosa by 10 min (P<0.01). Confocal microscopy and crystal violet staining analysis of bacterial biofilms treated with hypochlorous acid solution both demonstrated that biofilm bacteria were readily killed, but biofilm structure was largely maintained.

Conclusions:
Hypochlorous acid (0.01%) hygiene solution was able to achieve bactericidal levels of killing of bacteria in biofilms but did not disrupt biofilm structures. Susceptibility of tested staphylococcal blepharitis isolates varied by species, with S. capitis being the most susceptible and S. epidermidis being the least susceptible.
Stenotrophomonas maltophilia—A Case Series of a Rare Keratitis Affecting Patients With Bandage Contact Lens
Authors: Hogg Henry D. J. , Siah We Fong , Okonkwo Arthur , Narayanan Manjusha , Figueiredo Francisco C. 
Published: January 2018

Objectives:

Stenotrophomonas maltophilia is an opportunistic pathogen known to form biofilms on contact lens and case surfaces that may result in permanent visual loss in cases of microbial keratitis. Because of its multiple drug resistance and extremely low incidence, there is little consensus on treatment. We investigated the predisposing factors, management, and visual outcomes in a small case series of patients to better inform the management of this rarely reported keratitis.

Methods:
Retrospective analysis of medical records was performed at a single tertiary referral center between 2011 and 2017. The case notes of each microbiology confirmed S. maltophilia keratitis were examined.

Results:
Six cases were identified (four men) with a median age of 62 years (range 1 month–90 years) and pre-existing ocular surface disease in all cases. At presentation, four patients were using bandage contact lenses and three were on topical antibiotic and steroid medications. Initial antibiotic treatment was intensive topical 0.3% ofloxacin and 5% cefuroxime, which was modified based on corneal scrape culture and sensitivity and clinical findings. One patient chose not to complete the treatment course. The 5 remaining patients had complete resolution of ulceration over a mean of 2.9 months (SD 0.8 months).

Conclusions:
Contact lens in the context of ocular surface problems, prolonged topical antibiotic and steroid treatments may predispose to S. maltophilia, a rare cause of keratitis. We report successful treatment with case-specific combinations of topical antibiotics such as fluoroquinolone, cotrimoxazole, and/or cephalosporin agents, although visual outcomes remain poor due to corneal scar.
Health Service Utilization Among People With Noncommunicable Diseases in Rural Vietnam
Authors: Van Minh Hoang , Oh Juhwan , Giang Kim Bao , Bao Ngoc Nguyen , Minh Hoang Nguyen , Giang Huong Tran Thi , Van Huy Nguyen , Son Dinh Thai , Lee Jong-Koo , Hoat Luu Ngoc 
Published: January 2018

Context:
Chronic noncommunicable diseases (NCDs) have been shown to be major causes of morbidity and mortality in hospitals for the whole country.

Objective:
This study aims to describe the situation of health service utilization among people with NCDs in a rural area and identify association between the situation of health service utilization among people with chronic diseases and their socioeconomic status.

Design:
This was a cross-sectional study.

Setting:
A rural district located in the North of Vietnam.

Participants:
People 15 years of age and older. Health service utilization was analyzed only among people who reported having NCD.

Main Outcome Measures:
Data were collected through a personal household interview conducted by 12 trained field workers. The dependent variable is health care service utilization among people with chronic NCDs. The explanatory variables include both household attributes such as household economic conditions, and so forth, and individual characteristics.

Results:
Eighteen percent of the adults and 51% of the elderly respondents reported having at least 1 of the NCDs. The proportions of people with NCDs who used at least 1 outpatient service and used at least 1 inpatient health service during the last 12 months were 68.1% and 10.7%, respectively (the nonutilization rates of 31.9% and 89.3%, respectively). The statistically significant correlates of health care service utilization among people with NCDs were ethnicity (ethnic minority was significantly associated with a lower odds of health care service utilization) and health insurance (no health insurance was significantly associated with lower odds of health care service utilization).

Conclusion:
Given the evidence from this study, actions to improve access to health care services among people with NCDs are clearly needed. The capacity of primary health care system for the prevention and control of NCDs should be ranked a top priority.
Universal Health Insurance Coverage in Vietnam: A Stakeholder Analysis From Policy Proposal (1989) to Implementation (2014)
Authors: Hoang Chi K. , Hill Peter , Nguyen Huong T. 
Published: January 2018

Context:
In 1989, health insurance (HI) was introduced in Vietnam and began to be implemented in 1992. There was limited progress until the 2014 Law on HI that was revised with the aim of universal health insurance coverage (UHIC) by 2020. This article explores stakeholder roles and positions from the initial introduction of HI to the implementation of the Master Plan accelerating UHIC.

Objective:
To better understand the influence of stakeholders in accelerating UHIC to achieve equity in health care.

Design:
Using a qualitative study design, we conducted content analysis of HI-related documents and interviewed social security and health system key informants, government representatives, and community stakeholders to determine their positions and influence on UHIC.

Results:
Our findings demonstrate different levels of support of stakeholders that influence in the HI formulation and implementation, from opposition when HI was first introduced in 1989 to collaboration of stakeholders from 2013 when the Master Plan for UHIC was implemented. Despite an initial failure to secure the support of the Parliament for a Law on HI, a subsequent series of alternative legislative strategies brought limited increases in HI coverage. With government financial subsidization, the involvement of multiple stakeholders, political commitment, and flexible working mechanisms among stakeholders have remained important, with an increasing recognition that HI is not only a technical aspect of the health system but also a broader socioeconomic and governance issue. The different levels of power and influence among stakeholders, together with their commercial and political interests and their different perceptions of HI, have influenced stakeholders' support or opposition to HI policies.

Conclusions:
Despite high-level policy support, stakeholders' positions may vary, depending on their perceptions of the policy implications. A shift in government stakeholder positions, especially at the provincial level, has been necessary to accelerate UHIC progress and build institutional capacity.
PD-1/PD-L1 Axis in Lung Cancer
Authors: Santini Fernando C. , Hellmann Matthew D. 
Published: January 2018

Abstract
Cancer immunotherapies have revolutionized the treatment of non–small cell lung cancer. Yet, only a small subset of patients will benefit from PD-1 or PD-L1 blockade. PD-L1 tumor cell expression is the only approved biomarker at present. Tumor mutational burden and other emerging biomarkers should improve patient selection. Combination therapy approaches with chemotherapy or cytotoxic T-lymphocyte-associated protein 4 blockade may increase the proportion of patients who benefit from immunotherapy. Although use of immunotherapy in lung cancers with targetable oncogenes has not been particularly successful, the benefit of PD-(L)1 inhibitors in early-stage disease is emerging. This review briefly describes the evolution of the clinical development and future directions of PD-(L)1 blockade in patients with lung cancers.
PD-L1 and Emerging Biomarkers in Immune Checkpoint Blockade Therapy
Authors: Cottrell Tricia R. , Taube Janis M. 
Published: January 2018

Abstract
PD-L1 checkpoint blockade is revolutionizing cancer therapy, and biomarkers capable of predicting which patients are most likely to respond are highly desired. The detection of PD-L1 protein expression by immunohistochemistry can enrich for response to anti–PD-(L)1 blockade in a variety of tumor types, but is not absolute. Limitations of current commercial PD-L1 immunohistochemical (IHC) assays and improvements anticipated in next-generation PD-L1 testing are reviewed. Assessment of tumor-infiltrating lymphocytes in conjunction with PD-L1 testing could improve specificity by distinguishing adaptive (interferon γ driven and cytotoxic T-lymphocyte associated) from constitutive (non–immune mediated) expression. The presence of a high tumor mutational burden also enriches for response to therapy, and early data indicate that this may provide additive predictive value beyond PD-L1 IHC alone. As candidate biomarkers continue to emerge, the pathologist's assessment of the tumor microenvironment on hematoxylin-eosin stain combined with PD-L1 IHC remains a rapid and robust way to evaluate the tumor-immune dynamic.
Is electroweak baryogenesis dead?
Authors: Cline James M. 
Published: January 2018

Electroweak baryogenesis is severely challenged in its traditional settings: the minimal supersymmetric standard model, and in more general two Higgs doublet models. Fine tuning of parameters is required, or large couplings leading to a Landau pole at scales just above the new physics introduced. The situation is somewhat better in models with a singlet scalar coupling to the Higgs so as to give a strongly first-order phase transition due to a tree-level barrier, but even in this case no UV complete models had been demonstrated to give successful baryogenesis. Here, we point out some directions that overcome this limitation, by introducing a new source of particle–antiparticle (CP) violation in the couplings of the singlet field. A model of electroweak baryogenesis requiring no fine tuning and consistent to scales far above 1 TeV is demonstrated, in which dark matter plays the leading role in creating a CP asymmetry that is the source of the baryon asymmetry.
This article is part of the Theo Murphy meeting issue ‘Higgs cosmology’.
Asymmetric effects of environmental filtering on the assembly of tropical bird communities along a moisture gradient
Authors: Gomez Juan Pablo , Robinson Scott , Ponciano Jose Miguel 
Published: January 2018

AbstractThe species-sorting hypothesis (SSH) states that environmental factors influence local community assembly of metacommunities by selecting for species that are well adapted to the specific conditions of each site. Along environmental gradients, the strength of selection against individuals that are marginally adapted to the local conditions increases towards the extremes of the environment where the climate becomes harsh. In rainfall gradients, the strength of selection by the environment has been proposed to decrease with rainfall. Under this scenario SSH would predict that immigration of individuals from the metacommunity should be restricted into the dry end of the gradient creating a positive relationship between immigration and rainfall. However, if the selection is strong in both ends of the gradient, the restriction should be expected to be in both directions such that the ends behave as independent metacommunities even in the absence of geographical barriers. In this study we used models based on neutral theory to evaluate if SSH can explain the distribution of bird species along a steep rainfall gradient in Colombia. We found a strong positive relationship between immigration rates and precipitation suggesting that the dry forests impose stronger challenges for marginally adapted bird populations. However, a two-metacommunity model separating dry and wet forests was a better fit to the observed data, suggesting that both extremes impose strong selection against immigrants. The switch from the dry forest to the wet forest metacommunities occurred abruptly over a short geographic distance in the absence of any apparent geographic barrier; this apparent threshold occurs where the forest becomes mostly evergreen. The relative number of rare species in dry forest was lower than in wet forests suggesting that the selection against marginally adapted populations is stronger in the dry forests. Overall, our analyses are consistent with SSH at the regional scales, but the rarity analysis suggests that the mechanisms at the local scales are substantially different. Based on these results, we hypothesize that abiotic (climatic) factors limit immigration into dry forest communities and whereas biotic factors such as competition and predation may limit immigration into bird communities in the wet forest.
Feasibility of clinician-facilitated 3D printing of synthetic cranioplasty flaps
Authors: Panesar Sandip S , Belo Joao Tiago A , D’Souza Rhett N 
Published: January 2018

AbstractObjectives3D scanning and stereolithographic printing technology becoming increasingly common, however its implementation into clinical practice is in its primacy. These technologies may be esoteric to the practicing neurosurgeon. We explored a range of 3D scanning and stereolithographic techniques to create patient-specific synthetic implants.MethodsWe simulated bilateral craniectomies from a single cadaveric specimen to create 3 methods of creating stereolithographically-viable virtual models. Firstly, we used ‘pre-and-post operative’ CT derived bony windows to create a virtual skull model, from which the flap was extracted. Secondly, we used an entry-level 3D light-scanner to scan and render models of the individual bone pieces. Thirdly, we used an arm-mounted, 3D laser-scanner to create virtual models using a real-time approach.ResultsFlaps were printed from the CT scanner and laser scanner models only, in a UV-cured polymer. The light scanner did not produce suitable virtual models for printing. The CT scanner derived models required extensive post-fabrication modification to fit the existing defects. The laser-scanner models assumed good fit within the defects without any modification.ConclusionsThe methods presented varying levels of complexity in acquisition and model rendering. Each technique required hardware at varying in price points from $0 to ∼$100,000. The laser-scanner models produced the best quality parts which bore near-perfect fit with the original defects. We discuss potential neurosurgical applications of this technology.
Loss of PRMT5 promotes PDGFRα degradation during oligodendrocyte differentiation and myelination
Authors: Calabretta Sara , Vogel Gillian , Yu Zhenbao , Choquet Karine , Darbelli Lama , Nicholson Thomas B. , Kleinman Claudia L. , Richard Stéphane 
Published: January 2018

SummaryPlatelet derived growth factor receptor α (PDGFRα) signaling is required for proliferation, commitment and maintenance of oligodendrocyte (OL) precursor cells (OPCs). PDGFRα signaling promotes OPC homeostasis and its attenuation signals OPC differentiation and maturation triggering the onset of myelination of the central nervous system (CNS). The initial steps of how PDGFRα signaling is attenuated are still poorly understood. Herein we show that decreased Protein Arginine MethylTransferase5 (PRMT5) expression, as occurs during OPC differentiation, is involved in the down-regulation of PDGFRα by modulating its cell surface bioavailability leading to its degradation in a Cbldependent manner. Mechanistically, loss of arginine methylation at R554 of the PDGFRα intracellular domain reveals a masked Cbl binding site at Y555. Physiologically, depletion of PRMT5 in OPCs results in severe CNS myelination defects. We propose that decreased PRMT5 activity initiates PDGFRα degradation to promote OL differentiation. More broadly, inhibition of PRMT5 may be used therapeutically to manipulate PDGFRα bioavailability.