bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mortality and health-related quality of life in patients surgically treated for spondylodiscitis
Authors: Dragsted Casper , Aagaard Theis , Ohrt-Nissen Søren , Gehrchen Martin , Dahl Benny 
Published: June 2017

Purpose: To assess mortality, disability, and health-related quality of life (HRQL) in patients surgically treated for spondylodiscitis. Methods: A retrospective longitudinal study was conducted on all patients surgically treated for spondylodiscitis over a 6-year period at a single tertiary spine center. Indications for surgery, pre- and postoperative neurological impairment, comorbidities, and mortality were recorded. A survey was conducted on all eligible patients with the EuroQol 5-dimension (EQ-5D) questionnaire and Oswestry Disability Index (ODI). Results: Sixty-five patients were diagnosed with spondylodiscitis not related to recent spine surgery. One-year mortality rate was 6%. In all, 36% and 27% had pre- and postoperative neurological impairment, respectively, with only one patient experiencing deterioration postoperatively. At final follow-up (median 2 years), mean ODI was 31% (SD = 22) and mean EQ-5D time trade-off score was 0.639 (SD = 0.262); this was significantly lower than that in the normal population ( p < 0.001). Patients with neurological impairment prior to index surgery had lower EQ-5D scores ( p = 0.005) and higher ODI ( p = 0.02) at final follow-up compared with patients without neurological impairment. Conclusions: Several years after surgery, patients surgically treated for spondylodiscitis have significantly lower HRQL and more disability than the background population. Neurological impairment prior to index surgery predicts adverse outcome in terms of disability and lower HRQL.
Comparison of clinical efficacy among remifentanil, nicardipine, and remifentanil plus nicardipine continuous infusion for hypotensive anesthesia during arthroscopic shoulder surgery
Authors: Kim Joon Yub , Song Seong Hun , Cho Jae Ho , Cho Hyung Rae 
Published: June 2017

Purpose: Hypotensive anesthesia is crucial during arthroscopic shoulder surgery to reduce bleeding and allow for clear visibility. The aim of this study was to compare the clinical efficacy of continuous infusion of remifentanil, nicardipine, and remifentanil plus nicardipine to control hypotensive anesthesia in arthroscopic shoulder surgery. Methods: For this study, we enrolled 45 consecutive patients who were scheduled to have arthroscopic rotator cuff repair surgery and randomly allocated them into remifentanil (group R, n = 15), nicardipine (group N, n = 15), and remifentanil plus nicardipine (group RN, n = 15) groups. During the surgeries, these drugs were administered with continuous infusion. We analyzed the mean arterial pressure (MAP) and heart rate during surgery, stay time in the recovery room, visual analogue scale (VAS) scores, use of antiemetics in the recovery room, and postoperative blood urea nitrogen and creatinine changes. Results: The VAS score in the recovery room was higher for group R (mean 5.6, SD 1.4) than for groups N (mean 3.9, SD 0.9) and RN (mean 4.0, SD 1.1; p = 0.000). There were no statistical differences regarding other clinical variables among the three groups (all p > 0.05) except for MAP at 120 min of surgery between groups N and RN (N: 84.67 (SD 10.7) mmHg, RN: 65.4 (SD 9.2) mmHg, p = 0.027). Conclusion: The continuous infusion of remifentanil plus nicardipine appeared to be advantageous for maintaining hypotensive anesthesia until 120 min of arthroscopic shoulder surgery without rebound pain in a postanesthesia care unit.
NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival
Authors: Prince Lynne R. , Prosseda Svenja D. , Higgins Kathryn , Carlring Jennifer , Prestwich Elizabeth C. , Ogryzko Nikolay V. , Rahman Atiqur , Basran Alexander , Falciani Francesco , Taylor Philip , Renshaw Stephen A. , Whyte Moira K. B. , Sabroe Ian 
Published: June 2017

Key PointsWe demonstrate an important role for NR4A receptors in regulating neutrophil lifespan and homeostasis in vitro and in vivo. These findings may define targets for therapies for diseases driven by defects in neutrophil number and/or survival.
Inserción de los países de la Alianza del Pacífico en Asia-Pacífico: más allá de las relaciones comerciales
Authors: Rojas Lozano Daniel , Terán Obando José Miguel 
Published: June 2017

El siglo XXI ha sido considerado como el siglo del Pacífico. La Alianza del Pacífico no es ajena a dicho fenómeno la cual, entre otros motivos, surgió para lograr una mejor inserción de sus países miembro en esta área y, más específicamente, en la parte asiática del Pacífico. Dicha inserción ha tendido a explicarse en términos de intercambios comerciales, los cuales se han incrementado en los últimos años y tienen una importancia central en las interrelaciones, pero no evidencian el amplio alcance que tienen las relaciones entre Chile, Colombia, México y Perú con Asia-Pacífico; además, la política exterior no se limita a la búsqueda de nuevos mercados y socios económicos. Este trabajo presenta una sistematización de tratados establecidos entre los países que son actualmente miembros de la Alianza del Pacífico con China, Corea y Japón entre los años 1990 y 2016. A partir del análisis comparado del conjunto de tratados se observa que el tema de comercio tiene una participación muy baja en la totalidad de las relaciones que se consolidan a través de los tratados.
La política de la despolitización. Un análisis de la construcción del relato PRO
Authors: Schuttenberg Mauricio 
Published: June 2017

Recientemente la alianza Cambiemos logró acceder al gobierno argentino por elecciones e incluso ganar un histórico bastión del peronismo como lo era la provincia de Buenos Aires. Este triunfo del PRO rompe con la histórica dificultad de la derecha de lograr acceder al poder por medios electorales. Esta situación, inesperada para un sector amplio de las ciencias sociales, reabre indudablemente el debate en torno a los alcances y a la naturaleza del proceso político en ciernes. El artículo propone un análisis del discurso político para mostrar la conformación de un relato que tiende a ocultar la dimensión conflictiva de la política y reemplazarla por una concepción consensualista a la vez que se construye desde una mirada deshistorizadora de nuestro pasado como elemento nodal del relato.
Comunicar el riesgo desde la anticipación. El Periodismo de Prevención, una propuesta.
Authors: Alende Castro Silvia 
Published: June 2017

Definida como sociedad del riesgo, la actual es una sociedad propensa a distintos tipos de trastornos y situaciones de inseguridad. En este contexto, la práctica social del periodismo se asocia con el aporte al sujeto de recursos y habilidades para desenvolverse en el medio social. En este sentido, se presenta una propuesta teórica acerca del Periodismo de Prevención (PdP) como una modalidad informativa que busca aproximarse a la cotidianeidad del lector por medio de la publicación anticipada de información de carácter útil que permita una adecuada gestión de riesgos en su entorno próximo. Así, en este trabajo se ofrecen los resultados de un estudio más amplio sobre el modelo teórico en el que se sustenta el Periodismo de Prevención así como sobre sus características de publicación, testadas a través del análisis de contenido. metodológicamente, este estudio plantea un análisis de más de 30000 unidades informativas revisadas en 406 ejemplares de 12 diarios españoles en galicia. Entre las principales conclusiones, esta investigación permite afirmar que el PdP se centra temáticamente en riesgos vinculados a la salud humana.
Insights into Diagenesis and Pore Structure of Opalinus Shale Through Comparative Studies of Natural and Reconstituted Materials
Authors: Seiphoori Ali , Whittle Andrew J. , Krakowiak Konrad J. , Einstein Herbert H. 
Published: June 2017

AbstractShales have undergone a complex burial diagenesis that involved a severe modification of the pore structure. Reconstituted shales can provide new insights into the nature of the pore structure in natural materials. The effects of diagenesis on the microfabric, pore size distribution, and porosity of Opalinus shale were measured by comparing the behavior of natural and reconstituted specimens. The parent material (Opalinus shale) was reconstituted through multiple grinding operations, sedimentation from a dispersed slurry, and one-dimensional isothermal consolidation. This process produced uniform specimens that were not cemented and had replicable microfabric and engineering properties. The microfabric and mineralogy of the materials were examined using high-resolution scanning/backscattered electron microscopy (SEM/BSEM) and energy-dispersive X-ray spectroscopy (EDS) for specimens with broken and milled surfaces. Mercury intrusion porosimetry (MIP) and N2 adsorption were used to assess the pore size distributions and specific surface areas of the materials. The microstructure of natural shale was characterized to be highly heterogeneous with significant concentrations of calcareous microfossils, calcite, and quartz particles embedded within the clay matrix. The microfossils were observed to be locally infilled and rimmed by a calcite cement that showed evidence of dissolution. The reconstituted specimens showed a double-structure microfabric that evolved with the level of consolidation stress and converged into a single-structure material (comparable to the natural shale) at a consolidation stress of more than twice the estimated maximum in situ effective stress. The natural shale had a lower specific surface area in comparison to the reconstituted material, which was consolidated at large effective stresses. These differences can be attributed to cementation at a submicron pore scale and highlight chemical diagenesis effects that were not replicated in the reconstituted specimens.
Analgesia and Opioids: A Pharmacogenetics Shortlist for Implementation in Clinical Practice
Authors: Matic Maja , de Wildt Saskia N , Tibboel Dick , van Schaik Ron H N 
Published: June 2017

Abstract

BACKGROUND
The use of opioids to alleviate pain is complicated by the risk of severe adverse events and the large variability in dose requirements. Pharmacogenetics (PGx) could possibly be used to tailor pain medication based on an individual's genetic background. Many potential genetic markers have been described, and the importance of genetic predisposition in opioid efficacy and toxicity has been demonstrated in knockout mouse models and human twin studies. Such predictors are especially of value for neonates and young children, in whom the assessment of efficacy or side effects is complicated by the inability of the patient to communicate this properly. The current problem is determining which of the many potential candidates to focus on for clinical implementation.

CONTENT
We systematically searched publications on PGx for opioids in 5 databases, aiming to identify PGx markers with sufficient robust data and high enough occurrence for potential clinical application. The initial search yielded 4257 unique citations, eventually resulting in 852 relevant articles covering 24 genes. From these genes, we evaluated the evidence and selected the most promising 10 markers: cytochrome P450 family 2 subfamily D member 6 (CYP2D6), cytochrome P450 family 3 subfamily A member 4 (CYP3A4), cytochrome P450 family 3 subfamily A member 5 (CYP3A5), UDP glucuronosyltransferase family 2 member B7 (UGT2B7), ATP binding cassette subfamily B member 1 (ABCB1), ATP binding cassette subfamily C member 3 (ABCC3), solute carrier family 22 member 1 (SLC22A1), opioid receptor kappa 1 (OPRM1), catechol-O-methyltransferase (COMT), and potassium voltage-gated channel subfamily J member 6 (KCNJ6). Treatment guidelines based on genotype are already available only for CYP2D6.

SUMMARY
The application of PGx in the management of pain with opioids has the potential to improve therapy. We provide a shortlist of 10 genes that are the most promising markers for clinical use in this context.
Plants foraged by bees for honey production in northern India: The diverse flora of India and its implications for apiculture
Authors: Chauhan Mohan Singh , Farooqui Anjum , Trivedi Anjali 
Published: June 2017

AbstractThe plants foraged by bees for honey production vary from place to place in the diverse flora of India. This paper reports a palynological study of honey from eight sites of agriculture and urbanisation in the Gangetic Plain of Uttar Pradesh (UP), and presents data from similar studies done in India. Pollen grains of 55 species were recorded in the honey from south-western, central and eastern parts of Uttar Pradesh, whereAgeratum conyzoides, a noxious invasive weed, is a very dominant plant taxon. The second plant community used for foraging by honeybees consists ofSyzygium cumini,Feronia limonia,Eucalyptus globulus,Prosopis spicigera,Prosopis juliflora,Brassica campestris,Pimpinella tomentosa,Xanthium strumarium, andZiziphussp. The third plant community foraged by honeybees includes diverse plant species such asCapparissp.,Ficussp.,Murraya koenigii,Aegle marmelos, andTinospora cordifolia, as well as Caryophyllaceae and nectarless families. The last group of plants foraged by honeybees comprises ca 37 species sparsely present in the vicinity. If honeybees have access to their preferred plant species they rarely visit non-preferred species, but in the urban and rural agricultural areas where the vegetation is sparse they are forced to forage several other plants including invasive species. The quality and character of honey, whether multifloral, monofloral, or bifloral, largely indicates the changing pattern of vegetation in a particular area, and can furnish decadal to century-scale information about the vegetational changes induced by climate or anthropopression. Palynological data also shed light on medicinally important or allergenic pollen protein present in honey (valuable information for consumers) and the details about plant taxa foraged by honeybees can be used for branding and marketing particular types of honey.
The use of previously known languages in the oral production of L3 English learners: A pseudolongitudinal study
Authors: Arratibel-Irazusta Izaskun , Martínez Adrián María 
Published: June 2017

AbstractRecent studies have concluded that type of language teaching programs such as Content and Language Integrated Learning (CLIL) may have an effect on the use of previously known languages. Most of the studies that have tackled the use of previously known languages in the CLIL literature have compared CLIL to non-CLIL learners. However, few (pseudo)longitudinal studies have been conducted in this respect. This paper will try to fill this gap by examining the use of previously known languages (L1 Spanish/L2 Basque) in an oral narration task in two different age/proficiency CLIL groups. Participants are Basque/Spanish bilinguals learning English as a third language (L3) in a CLIL setting. Both groups started learning English at the age of 3 but differ in length and amount of exposure. Results show that both groups behave in the same way in terms of the use of previously known languages except for the production of foreignizings, which were more frequent in the younger group. The examination of the results also revealed that discourse markers was the most common manifestation of use of previous linguistic experience when compared to the rest of the categories.
The effect of storage and processing on vitamin C content in Japanese quince fruit
Authors: Bieniasz Monika , Dziedzic Ewa , Kaczmarczyk Elżbieta 
Published: June 2017

Abstract
Stability of vitamin C in stored fruit and sugar syrup of Japanese quince was tested. Vitamin C was measured in the fruit at harvest and after a few weeks of storage under normal atmospheric conditions. Sugar syrup obtained from the fruit was subjected to analysis before and after pasteurisation, and after several weeks of storage. The Chaenomeles genotypes tested were valuable in terms of vitamin C content. Storage significantly reduced the vitamin C content in the fruit, by 20% on average after 2 weeks of storage. The mechanical treatment and preparation of sugar syrup decreased the vitamin content by nearly two-thirds when compared with the fruit at harvest. Pasteurisation and storage of the sugar syrup contributed to further losses of vitamin C, reducing it to a very low level.
Improvement of shear strength, wood failure percentage and wet delamination of cross-laminated timber (CLT) panels made with superheated steam treated (SHST) layers of larch wood
Authors: Han Yeonjung , Park Yonggun , Chang Yoon-Seong , Chung Hyunwoo , Eom Chang-Deuk , Yeo Hwanmyeong 
Published: June 2017

AbstractCross-laminated timber (CLT) panels – consisting of several cross-wise stacked layers of glued boards – have a high dimensional stability. However, the outer surfaces of CTL are exposed to environmental humidity changes and thus to swelling and shrinking. To improve CLT’s dimensional stability further, the layers of kiln dried (KD) CLT were substituted partly (on the surfaces) and entirely with superheated steam treated (SHST) wood. The effects of SHST wood and the performance of the one-component polyurethane resin (PUR) were tested by block shear and delamination tests after water soaking. Under various conditions, the shear strength ranged from 1.3 MPa to 4.7 MPa and the wood failure percentage (WFP) from 76% to 92%. The optimal parameter were ascertained as pressing time (30–45 min), pressure (0.98 MPa) and adhesive amount (175–200 g m−2). The water soaked delamination of CLT manufactured with SHST wood was approximately 50% lower than that of CLT made of KD wood.
Research Progress on Infectious Inflammation Markers in Blood
Authors: Dong Xifeng 
Published: June 2017

AbstractAcute phase protein (APP) is a type of special protein closely related to infection inflammation. In recent years, a large number of studies have shown that multiple positive and negative APPs, including C-reactive protein, serum amyloid A, procalcitonin, haptoglobin, alpha1 acid glycoprotein, ceruloplasmin, fibrinogen, prealbumin, leptin, albumin, and plasma fibronectin, are significantly correlated to infectious inflammation and that this method is more accurate and reliable than somatic cell test, erythrocyte sedimentation rate test, enzyme activity and content change test, and the like. Therefore, APP could be used as an infectious inflammation marker.
New Research Progress in Mycoplasma pneumoniae Infection
Authors: Li Fengtan 
Published: June 2017

AbstractAs an important pathogen of respiratory tract infection,Mycoplasma pneumoniae (MP)may not only lead to primary atypical pneumonia but also cause systemic organ conditions. MP causes respiratory tract infection among school-age children and is also an important infectious agent for adult respiratory tract infection. Intensive studies on roles ofMPinfection on the innate immune system significantly aid development of targeted therapy drugs. Epidemic studies on associated symptoms also help in clinical prevention and diagnosis and show importance to personalized treatment utilizing different drugs for different patients. This study summarizes the abovementioned three points based onMPstudies in recent years.
Advances in Animal Models of Hepatitis B Virus Infection
Authors: Zhang Hang 
Published: June 2017

Abstract
Hepatitis B virus (HBV) infection seriously affects human health. Stable and reliable animal models of HBV infection bear significance in studying pathogenesis of this health condition and development of intervention measures. HBV exhibits high specificity for hosts, and chimpanzee is long used as sole animal model of HBV infection. However, use of chimpanzees is strictly constrained because of ethical reasons. Many methods were used to establish small-animal models of HBV infection. Tupaia is the only nonprimate animal that can be infected by HBV. Use of HBV-related duck hepatitis virus and marmot hepatitis virus infection model contributed to evaluation of mechanism of HBV replication and HBV treatment methods. In recent years, development of human–mouse chimeric model provided possibility of using common experimental animals to carry out HBV research. These models feature their own advantages and disadvantages and can be complementary in some ways. This study provides an overview of current and commonly used animal models of HBV infection.
Advances in Epidemiological Studies of Herpes Zoster
Authors: Liu Yuan 
Published: June 2017

AbstractHerpes zoster (HZ) is a varicella zoster virus (VZV) that attacks locality of nerves and skin, resulting information of clusters of blisters on the skin connected unilateral facial nerve and accompanying apparent nerve pain. Incidence ranges from 3.2 to 4.2 per 1000 populations per year in the United States. Influence factors of HZ include age, infection history with VZV, vaccination history of varicella vaccine, reduced immunocompetence, and other diseases. Current domestic studies on HZ mainly focus on clinical reports of case treatment. This study reviews advances in foreign epidemiological studies of HZ.
Analysis on Risk Factors of Nosocomial Infection in Orthopedic Patients and Research on Nursing Strategies
Authors: Guo Zhitao 
Published: June 2017

Abstract
Orthopedic patients mostly comprise traumatic patients and elderly or sick individuals. More patients with emergency surgery suffer from open wounds and serious pollution, and operation time is relatively long. Thus, orthopedic patients with surgical incision infection account for a large proportion of incidence of hospital infection. Orthopedic patients are also bedridden for long periods, and they receive poor bone tissue blood supply. In surgical incision infections, mild cases suffer from delayed wound healing, whereas severe cases can form osteomyelitis. This study reviews progress of research on risk factors of nosocomial infection among orthopedic patients in recent years.
Topological Optimization of Communication Networks by Modeling and Management of Information Flows
Authors: Trichkov K. , Trichkova E. 
Published: June 2017

Abstract
This paper has a main goal which is to offer a topology synthesis through modelling and management of information flows. To proposes an optimal solution for changing the existing communication network from type “star” to a dual- or triple-connected topology. To proposes a model for quantifying the quality, the continuity and fault tolerance of services provided to achieve a technologic and structural improvement of the communication network.
Decoupling Fuzzy-Neural PID Controller for TITO Nonlinear Systems
Authors: Ganchev I. , Ahmed S. , Taneva A. , Petrov M. 
Published: June 2017

AbstractThis paper presents a fuzzy-neural structure of a Decoupling Fuzzy PID controller with self-tuning parameters. This structure is appropriate for Two-Input-Two-Output (TITO) nonlinear system. The main advantage here is that the equation of classical PID control and decoupling coefficients are used as a Sugeno function into the fuzzy rules. Hence the designed decoupling fuzzy PID controller can be viewed as a natural similarity to the conventional one with decoupling elements. A benchmark quadruple tank, implementing a TITO nonlinear system is considered to illustrate the benefits of the design paradigm. The performance of this set up was studied for reference tracking and disturbance rejection cases. Simulation results confirm the effectiveness of the proposed solution.