bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergence of cutaneous neosporosis in a dog receiving immunosuppressive therapy: molecular identification and management
Authors: Legnani Sara , Pantchev Nikola , Forlani Annalisa , Zini Eric , Schares Gereon , Balzer Jörg , Roccabianca Paola , Ferri Filippo , Zanna Giordana 
Published: December 2015

BackgroundNeosporosis is a multisystemic disease caused by the intracellular protozoan Neospora caninum. In dogs the disease primarily affects the central nervous system. Canine cutaneous neosporosis is a rare condition often associated with old age or concurrent immunosuppressive treatments for different underlying conditions.AnimalsA 10‐year‐old female spayed golden retriever dog affected by primary immune‐mediated myelofibrosis and treated with immunosuppressive therapies for 6 weeks that developed severe cutaneous lesions.MethodsDefinitive diagnosis was based on several investigation techniques including serology (immunoblotting), immunohistochemistry (IHC), species‐specific conventional and real‐time PCR, and DNA sequencing.ResultsRemission of cutaneous neosporosis was obtained with the administration of clindamycin while the concurrent immunosuppressive therapy was maintained to manage the underlying primary condition.Conclusions and clinical importanceTo the best of the authors' knowledge this is the first report of species‐specific PCR and DNA sequencing used as diagnostic methods for canine cutaneous neosporosis emerging in a dog receiving immunosuppressive therapy.
Long‐term effect of different tillage systems on the emergence and demography of Bromus diandrus in rainfed cereal fields
Authors: Recasens J , García A L , Cantero‐Martínez C , Torra J , Royo‐Esnal A 
Published: December 2015

SummaryThe adoption of no‐tillage systems in semi‐arid cereal fields in northern Europe has resulted in difficulties in controlling Bromus diandrus. However, in some fields, lower densities are observed in continuous long‐term no‐tillage management than in other reduced tillage systems. A cumulative effect on the seedbank could promote changes in the period of seedling emergence and in population demography. This study evaluated the effect of long‐term mouldboard plough (MbP), chisel plough (ChP), subsoiler (SS) and no‐tillage (NT) on the population dynamics of B. diandrus. The work was carried out in a barley (Hordeum vulgare)–wheat (Triticum aestivum)–barley rotation during three seasons where these soil management systems had been applied for the last 22 years. Cumulative emergence (CE) and densities of B. diandrus followed a gradient of ChP > SS > NT > MbP. This cumulative effect over time resulted in significant differences in population demography. A previous hydrothermal emergence model developed for this species estimated the percentage of emergence prior to the date of sowing to be: 71%, 92% and 53% for the seasons 2008–2009, 2009–2010 and 2010–2011 respectively. Furthermore, the reduction in CE observed was on average 53% in SS, 92% in NT and 98% in MbP in comparison with that recorded in ChP. The long‐term effect of different tillage systems tended to cause changes to soil characteristics (photo‐inhibition of germination, soil temperature, water availability) affecting B. diandrus demography, reaching equilibrium in weed densities over years, which were significantly lower in MbP and NT than in ChP or SS.
Determination of fatty acids content, global antioxidant activity and energy value of weed seeds from agricultural fields in France
Authors: Bretagnolle F , Matejicek A , Gregoire S , Reboud X , Gaba S 
Published: December 2015

SummaryThe ecological consequences of seed size variation have been studied extensively in plants. Curiously, little attention has been paid to the qualitative and quantitative variation of the seed‐stored molecules and on their ecological significance. Here, we analysed the oil content and oil composition of ca. 200 weed seed species from agricultural fields in France based on single seed accessions, concentrating on interspecies differences and ignoring within‐species variation. The relationships between seed weight, oil %, fatty acids (FAs) and the energetic value of the seed and its antioxidant properties were also investigated. The antioxidant activity could contribute to protect the oily seed reserves from alteration over time. Among the species analysed, we found a considerable quantitative (oil%) and qualitative variation of FAs stored in the seeds. Such variation was largely related to the plant family of the different species, but intrafamily variation was also found. Heavier seeds contained less oil on a per gram basis than lighter seeds, suggesting a trade‐off between seed weight and oil ratio in the seed and that oil storage strategy depends on seed size. Moreover, oily seeds contained more polyunsaturated FAs. However, contrary to our hypothesis, we did not found a higher antioxidant capability in oily seed extracts than in non‐oily seeds, nor to the quantitative or to the qualitative variation of FAs in the seeds. Considering the role of these important trait variations on weed ecological strategies, such as germination period, seed predation rate and competition–colonisation trade‐off, could improve the sustainable management of weed communities.
The Influence of Clinical Decision Support on Diagnostic Accuracy in Nurse Practitioners
Authors: Vetter Mary Jo 
Published: December 2015

ABSTRACTBackgroundClinical decision support systems (CDSSs) at the point of care are evidence‐based interventions that have demonstrated incremental positive impact on quality of healthcare delivery over the past two decades. Existing best practices inform strategies to promote adoption and achievement of targeted outcomes. The purpose of this improvement project was to conduct a pilot implementation to understand the contextual factors and readiness for dissemination of a newly acquired electronic CDSS by evaluating its influence on diagnostic accuracy in nurse practitioners (NPs) functioning in a community health setting.AimsThe specific aims of this project were to measure and compare diagnostic accuracy in a pilot group before and after CDSS use, educate clinicians about the system and pilot its use, and then leverage the experience to design the practice–wide CDSS dissemination strategy.MethodsThe project engaged a subset of NPs from a home–based primary care practice and other organizational stakeholders who provided tangible support and necessary resources for successful adoption of this innovation in practice. A structured conceptual model of Evidence‐Based Practice Improvement enhanced with elements of the Promoting Action on Research Implementation in Health Sciences framework was used to guide the development, implementation and evaluation of this practice improvement initiative.A group of seven NP representatives of the practice participated in the project. Data collection was composed of small tests of change (plan‐do‐study‐act) cycles at the local practice level, measuring achievement of improvement of the chosen outcome of correctness of medical diagnosis evidenced by appropriate substantiating clinical documentation.Linking evidence to actionIn this home visiting primary care practice setting, use of a CDSS by NPs achieved eventual improvement in diagnostic accuracy and clinical documentation, as demonstrated on chart audit, though the improvement was not sustained over time. The pilot findings ultimately informed decision making about CDSS dissemination strategies and future uses of the system. When appropriately deployed, a CDSS offers the potential to improve professional practice, support differential diagnosis and evidence‐based treatment, and provide detailed information about the disease state to facilitate robust clinical documentation.
Revelación y teología de las religiones: J. Dupuis y A. Torres Queiruga en diálogo
Authors: Restrepo Jaramillo Luis Guillermo 
Published: December 2015

<p>¿Es posible la legitimación del pluralismo religioso desde la revelación cristiana? Entre los muchos teólogos contemporáneos que se han ocupado de la cuestión, proponemos un diálogo entre J. Dupuis y A. Torres Queiruga, que permite afirmar que la revelación por hechos y palabras, como la presenta la Dei Verbum, supone una acción salvífica de Dios en las religiones del mundo. El pluralismo religioso, entonces, no es extraño al plan divino de salvación.</p>
Texto, narrador y lector en Lc 10,25-37
Authors: Barrios Hernando 
Published: December 2015

<p>Exégesis y hermenéutica, comprensión, explicación y aplicación del texto son operaciones que continúan divorciadas en los inicios del siglo XXI. El análisis narrativo se encamina al diálogo texto-lector en el contexto de las racionalidades<br />relacionadas con la literatura, la comunicación y la filosofía del lenguaje. Texto-narrador-lector forman un triángulo inseparable, tanto en la génesis como en la interpretación del texto. El artículo presenta la exégesis narrativa de Lc 10,25-37 a partir de la relación texto-narrador-lector, sujetos con su propio horizonte y con la posibilidad de diálogo entre ellos.</p>
Athletic groin pain (part 1): a prospective anatomical diagnosis of 382 patients—clinical findings, MRI findings and patient-reported outcome measures at baseline
Authors: Falvey É C , King E , Kinsella S , Franklyn-Miller A 
Published: December 2015

BackgroundAthletic groin pain remains a common field-based team sports time-loss injury. There are few reports of non-surgically managed cohorts with athletic groin pain.AimTo describe clinical presentation/examination, MRI findings and patient-reported outcome (PRO) scores for an athletic groin pain cohort.MethodsAll patients had a history including demographics, injury duration, sport played and standardised clinical examination. All patients underwent MRI and PRO score to assess recovery. A clinical diagnosis of the injured anatomical structure was made based on these findings. Statistical assessment of the reliability of accepted standard investigations undertaken in making an anatomical diagnosis was performed.Result382 consecutive athletic groin pain patients, all male, enrolled. Median time in pain at presentation was (IQR) 36 (16–75) weeks. Most (91%) played field-based ball-sports. Injury to the pubic aponeurosis (PA) 240 (62.8%) was the most common diagnosis. This was followed by injuries to the hip in 81 (21.2%) and adductors in 56 (14.7%) cases. The adductor squeeze test (90° hip flexion) was sensitive (85.4%) but not specific for the pubic aponeurosis and adductor pathology (negative likelihood ratio 1.95). Analysed in series, positive MRI findings and tenderness of the pubic aponeurosis had a 92.8% post-test probability.ConclusionsIn this largest cohort of patients with athletic groin pain combining clinical and MRI diagnostics there was a 63% prevalence of PA injury. The adductor squeeze test was sensitive for athletic groin pain, but not specific individual pathologies. MRI improved diagnostic post-test probability. No hernia or incipient hernia was diagnosed.Clinical trial registration numberNCT02437942.
The incidence of concussion in youth sports: a systematic review and meta-analysis
Authors: Pfister Ted , Pfister Ken , Hagel Brent , Ghali William A , Ronksley Paul E 
Published: December 2015

ObjectiveTo conduct a comprehensive systematic review and meta-analysis of studies assessing the incidence of concussion in youth athletes. Specifically, we estimate the overall risk of concussion in youth sports and compare sport-specific estimates of concussion risk.DesignSystemic review and meta-analysis.Data sourcesA search of Medline, Embase (1980 through September 2014), and SportDiscus (1985 through September 2014) supplemented by manual searches of bibliographies and conference proceedings.Inclusion criteriaWe included studies if they met the inclusion criteria of study design (prospective cohort study), relevant sports identified from the literature (eg, American football, rugby, hockey, lacrosse, soccer/football, basketball, baseball, softball, wrestling, field hockey, track, taekwondo, volleyball and cheerleading), population (males and females ≤18 years old), and outcome (concussion).ResultsOf the 698 studies reviewed for eligibility, 23 articles were accepted for systematic review and 13 of which were included in a meta-analysis. Random effects models were used to pool overall and sport-specific concussion incidence rates per 1000 athlete exposures (AEs). The overall risk of concussion was estimated at 0.23 (95% CI 0.19 to 0.28). The three sports with the highest incidence rates were rugby, hockey and American football at 4.18, 1.20 and 0.53, respectively. Lowest incidence rates per 1000 AEs occurred in volleyball, baseball and cheerleading at 0.03, 0.06 and 0.07, respectively. Quality of the included studies varied, with the majority of studies not reporting age and gender-specific incidence rates or an operational definition for concussion.ConclusionsThere are striking differences in the rates of incident youth concussion across 12 sports. This systematic review and meta-analysis can serve as the current sport-specific baseline risk of concussion among youth athletes.
Professional Rugby Union players have a 60% greater risk of time loss injury after concussion: a 2-season prospective study of clinical outcomes
Authors: Cross Matthew , Kemp Simon , Smith Andrew , Trewartha Grant , Stokes Keith 
Published: December 2015

AimTo investigate incidence of concussion, clinical outcomes and subsequent injury risk following concussion.MethodsIn a two-season (2012/2013, 2013/2014) prospective cohort study, incidence of diagnosed match concussions (injuries/1000 h), median time interval to subsequent injury of any type (survival time) and time spent at each stage of the graduated return to play pathway were determined in 810 professional Rugby Union players (1176 player seasons).ResultsMatch concussion incidence was 8.9/1000 h with over 50% occurring in the tackle. Subsequent incidence of any injury for players who returned to play in the same season following a diagnosed concussion (122/1000 h, 95% CI 106 to 141) was 60% higher (IRR 1.6, 95% CI 1.4 to 1.8) than for those who did not sustain a concussion (76/1000 h, 95% CI 72 to 80). Median time to next injury following return to play was shorter following concussion (53 days, 95% CI 41 to 64) than following non-concussive injuries (114 days, 95% CI 85 to 143). 38% of players reported recurrence of symptoms or failed to match their baseline neurocognitive test during the graduated return to play protocol.Summary and conclusionsPlayers who returned to play in the same season after a diagnosed concussion had a 60% greater risk of time-loss injury than players without concussion. A substantial proportion of players reported recurrence of symptoms or failed to match baseline neurocognitive test scores during graduated return to play. These data pave the way for trials of more conservative and comprehensive graduated return to play protocols, with a greater focus on active rehabilitation.
Great Britain Rowing Team Guideline for diagnosis and management of rib stress injury: Part 1
Authors: Evans Guy , Redgrave Ann 
Published: December 2015

BackgroundRib stress injury (RSI) is the development of pain due to bone oedema caused by overload along the rib shaft and is commonly seen in rowers. Often clinicians who manage this injury are experienced with the condition at the elite level. There may, however, be a lack of confidence in diagnosing and managing this condition by clinicians who are not regularly exposed to this injury. As a result, an evidence-based guideline has been developed to aid diagnosis and management of RSI.MethodsA detailed literature search was conducted reviewing the diagnosis and management of RSI. Detailed discussions were held by the Great Britain Rowing Medical Team to identify key issues in diagnosis and management of RSI. An up-to-date, evidence-based approach to managing RSI was created using both expert knowledge and current literature to formulate a functional guideline outlining best practice in management of RSI in rowers.ResultsA clinical guideline has been created incorporating 5 key areas: diagnosis, severity grading, investigation, management and associated risk factors for RSI. Important indicators for each key area are incorporated within the guideline using relevant literature where possible alongside expert opinion. The guideline has deliberately been kept concise and tailored for use in the clinical setting.ConclusionsA new clinical guideline for management of RSIs has been developed to facilitate clinicians in identifying RSI, aiding accurate diagnosis and providing effective management. This guideline is to be disseminated to clinicians, rowing coaches and clubs throughout the UK.
Leadership and followership in the healthcare workplace: exploring medical trainees’ experiences through narrative inquiry
Authors: Gordon Lisi J , Rees Charlotte E , Ker Jean S , Cleland Jennifer 
Published: December 2015

ObjectivesTo explore medical trainees’ experiences of leadership and followership in the interprofessional healthcare workplace.DesignA qualitative approach using narrative interviewing techniques in 11 group and 19 individual interviews with UK medical trainees.SettingMultisite study across four UK health boards.ParticipantsThrough maximum variation sampling, 65 medical trainees were recruited from a range of specialties and at various stages of training. Participants shared stories about their experiences of leadership and followership in the healthcare workplace.MethodsData were analysed using thematic and narrative analysis.ResultsWe identified 171 personal incident narratives about leadership and followership. Participants most often narrated experiences from the position of follower. Their narratives illustrated many factors that facilitate or inhibit developing leadership identities; that traditional medical and interprofessional hierarchies persist within the healthcare workplace; and that wider healthcare systems can act as barriers to distributed leadership practices.ConclusionsThis paper provides new understandings of the multiple ways in which leadership and followership is experienced in the healthcare workplace and sets out recommendations for future leadership educational practices and research.
Study protocol for a phase III multicentre, randomised, open-label, blinded-end point trial to evaluate the efficacy and safety of immunoglobulin plus cyclosporin A in patients with severe Kawasaki disease (KAICA Trial)
Authors: Aoyagi Reiko , Hamada Hiromichi , Sato Yasunori , Suzuki Hiroyuki , Onouchi Yoshihiro , Ebata Ryota , Nagashima Kengo , Terauchi Moe , Terai Masaru , Hanaoka Hideki , Hata Akira 
Published: December 2015

IntroductionKawasaki disease (KD) is an acute, self-limited vasculitis of unknown aetiology that predominantly affects infants and young children. We hypothesise that cyclosporin A (CsA) may be effective in treating KD by regulating the Ca2+/NFAT signalling pathway. This trial compares the current standard therapy of intravenous immunoglobulin (IVIG) and the combined IVIG+CsA therapy in paediatric patients with severe KD.Methods and analysisThis trial is a phase III, multicentre, randomised, open-label, blinded-end point trial that evaluates the efficacy and safety of IVIG+CsA therapy. Patients with severe KD who satisfy the eligibility criteria are randomised (1:1) to receive either CsA (5 mg/kg/day for 5 days; Neoral) plus high-dose IVIG (2 g/kg for 24 h and aspirin 30 mg/kg/day), or high-dose IVIG alone (2 g/kg for 24 h and aspirin 30 mg/kg/day). The primary end point is the frequency of occurrence of coronary artery abnormalities during the trial period. An independent end point review committee will be in charge of the trial assessment.Ethics and disseminationThe protocol was approved by the Institutional Review Board of each institution. The trial was notified and registered at the Pharmaceutical and Medical Devices Agency, in Japan. The trial is currently on-going and is scheduled to finish in April 2017. The findings will be disseminated through peer-reviewed publications and conference presentations.Trial registration numberJMA-IIA00174; Pre-results.
Physiological and biochemical variables in captive tigers (Panthera tigris) immobilised with dexmedetomidine and ketamine or dexmedetomidine, midazolam and ketamine
Authors: Clark‐Price S. C. , Lascola K. M. , Schaeffer D. J. 
Published: December 2015

Physiological and biochemical variables in captive tigers (Panthera tigris) immobilised with dexmedetomidine and ketamine or dexmedetomidine, midazolam and ketamine were evaluated. Thirty tigers received either dexmedetomidine (0.025 mg/kg) and ketamine (3 mg/kg) (group DK) or dexmedetomidine (0.0125 mg/kg), midazolam (0.1 mg/kg) and ketamine (3 mg/kg) (group DMK). Heart rate, SPO2and blood pressure were measured at five‐minute intervals. Arterial pH, PO2, PCO2, glucose, K+and arterial and venous lactate were measured at 15 and 45 minutes after immobilisation. A generalised linear mixed model was used for statistical comparison. There was no difference within or between groups at any time point for any measured variable. Measured PO2was 73.2±17.5 mm Hg and SPO2was 88.9±10.8 per cent. Systolic, mean and diastolic blood pressures were 170.5±48.4, 138.9±41.8 and 121.8±37.2 mm Hg, respectively. Venous lactate was higher than arterial lactate within groups at each time point. Seizure‐like behaviour was observed in 25 per cent of tigers in group DK but not in group DMK. The addition of midazolam into a protocol for immobilisation of tigers did not result in a difference in any of the measured variables but may have prevented the development of seizure‐like behaviour.
The CDK9 Inhibitor Dinaciclib Exerts Potent Apoptotic and Antitumor Effects in Preclinical Models of MLL-Rearranged Acute Myeloid Leukemia
Authors: Baker Adele , Gregory Gareth P. , Verbrugge Inge , Kats Lev , Hilton Joshua J. , Vidacs Eva , Lee Erwin M. , Lock Richard B. , Zuber Johannes , Shortt Jake , Johnstone Ricky W. 
Published: December 2015

Abstract
Translocations of the mixed lineage leukemia (MLL) gene occur in 60% to 80% of all infant acute leukemias and are markers of poor prognosis. MLL-AF9 and other MLL fusion proteins aberrantly recruit epigenetic regulatory proteins, including histone deacetylases (HDAC), histone methyltransferases, bromodomain-containing proteins, and transcription elongation factors to mediate chromatin remodeling and regulate tumorigenic gene expression programs. We conducted a small-molecule inhibitor screen to test the ability of candidate pharmacologic agents targeting epigenetic and transcriptional regulatory proteins to induce apoptosis in leukemic cells derived from genetically engineered mouse models of MLL-AF9–driven acute myeloid leukemia (AML). We found that the CDK inhibitor dinaciclib and HDAC inhibitor panobinostat were the most potent inducers of apoptosis in short-term in vitro assays. Treatment of MLL-rearranged leukemic cells with dinaciclib resulted in rapidly decreased expression of the prosurvival protein Mcl-1, and accordingly, overexpression of Mcl-1 protected AML cells from dinaciclib-induced apoptosis. Administration of dinaciclib to mice bearing MLL-AF9–driven human and mouse leukemias elicited potent antitumor responses and significantly prolonged survival. Collectively, these studies highlight a new therapeutic approach to potentially overcome the resistance of MLL-rearranged AML to conventional chemotherapies and prompt further clinical evaluation of CDK inhibitors in AML patients harboring MLL fusion proteins. Cancer Res; 76(5); 1158–69. ©2015 AACR.