bluuebunny/crossref_metadata_2025_split huggingface dataset:
Disaster preparedness among nurses: a systematic review of literature
Authors: Labrague L.J. , Hammad K. , Gloe D.S. , McEnroe‐Petitte D.M. , Fronda D.C. , Obeidat A.A. , Leocadio M.C. , Cayaban A.R. , Mirafuentes E.C. 
Published: March 2017

AimThis review explored peer‐reviewed publications that measure nurses’ preparedness for disaster response.BackgroundThe increasing frequency of disasters worldwide necessitates nurses to adequately prepare to respond to disasters to mitigate the negative consequences of the event on the affected population. Despite growing initiatives to prepare nurses for any disasters, evidence suggests they are under prepared for disaster response.MethodsThis is a systematic review of scientific articles conducted from 2006 to 2016 on nurses’ preparedness for disasters. SCOPUS, MEDLINE, PubMed, CINAHL and PsychINFO were the primary databases utilized for search of literature. Keywords used in this review were as follows: ‘emergency’, ‘disaster’, ‘disaster preparedness’, ‘disaster competencies’, ‘disaster nursing’, ‘disaster role’ and ‘nurse’. Seventeen (17) articles were selected for this review.FindingsFactors that increase preparedness for disaster response include previous disaster response experience and disaster‐related training. However, it is widely reported that nurses are insufficiently prepared and do not feel confident responding effectively to disasters.ConclusionThe findings of this review contribute to a growing body of knowledge regarding disaster preparedness in nurses and have implications for academia, hospital administration and nursing educators. The findings of this review provide evidence that could be used by nurse educators and nurse administrators to better prepare nurses for disaster response.Implications for nursing and health policyThe findings from this review place an emphasis on hospitals to implement policies to address lack of preparedness among their employees. Furthermore, this review highlights the benefit of further research and provision of well‐grounded disaster exercises that mimic actual events to enhance the preparedness of the nursing workforce.
Higher education and sustainability in Thailand: a review of National Research University roles in sustainable agriculture education
Authors: Visetnoi Supawan , Nelles Wayne 
Published: March 2017

AbstractThe agricultural sector has played a significant role in Thailand's national economy and is a major source of income for many Thais. Yet globally, and for much of South East Asia, agriculture is one of the greatest contributors to environmental problems. At the same time there have been many debates about Thailand's unsustainable agricultural system and the role of education in addressing such concerns.To illustrate broader issues and challenges this paper analyses related themes at an institutional level, while examining specific policies and concerns about sustainability among Thailand's nine government‐designated National Research Universities (NRUs). This paper reviews courses and programmes in sustainable agriculture (SA) offered by each NRU, research funding and budget allocations intended to contribute to sustainability and environmental awareness.Also, this study employs SWOT analysis to demonstrate strengths and weaknesses of sustainability and education in Thai NRUs. The results of this study suggest that national education plans and policies on SA learning and research to support NRUs seem unclear and there is still a lack of comprehensive SA courses and programmes with solid support from most Thai universities and the government. This paper is a first step to systematically document and explain the state of higher education about and for sustainable agriculture reflected in policies and practices of Thai universities and their implications for national development.
A bibliometric analysis of the Journal of Advanced Nursing, 1976–2015
Authors: Železnik Danica , Blažun Vošner Helena , Kokol Peter 
Published: March 2017

AbstractAimThe aim of this study was to examine the publication characteristics and development of Journal of Advanced Nursing during its 40‐year history.BackgroundBibliometric studies of single journals have been performed, but to the best of our knowledge, bibliometric analysis and bibliometric mapping have not yet been used to analyse the literature production of the Journal of Advanced Nursing.Design/MethodUsing descriptive bibliometrics, we studied the dynamics and trend patterns of literature production and identified document types and the most prolific authors, papers, institutions and countries. Bibliometric mapping was used to visualize the content of published articles and determine the most prolific research terms and themes published in Journal of Advanced Nursing and their evolution through time. We were also interested in determining whether there were any ‘Sleeping Beauties’ among the articles published in the journal.ResultsThe study revealed a positive trend in literature production, although recently, the number of articles published in Journal of Advanced Nursing has slightly decreased. The most productive institutions are from the United Kingdom, which ranks in the highest place in terms of successful publishing in the journal. Thematic analysis showed that the most prolific themes corresponded to the basic aims and scope of the journal.ConclusionJournal of Advanced Nursing contributes to advances in nursing research, practice and education as well as the quality of health care, teamwork and family care, with an emphasis on knowledge transfer and partnership between various healthcare professionals.
Uric acid ameliorates indomethacin‐induced enteropathy in mice through its antioxidant activity
Authors: Yasutake Yuichi , Tomita Kengo , Higashiyama Masaaki , Furuhashi Hirotaka , Shirakabe Kazuhiko , Takajo Takeshi , Maruta Koji , Sato Hirokazu , Narimatsu Kazuyuki , Yoshikawa Kenichi , Okada Yoshikiyo , Kurihara Chie , Watanabe Chikako , Komoto Shunsuke , Nagao Shigeaki , Matsuo Hirotaka , Miura Soichiro , Hokari Ryota 
Published: March 2017

AbstractBackground and AimUric acid is excreted from blood into the intestinal lumen, yet the roles of uric acid in intestinal diseases remain to be elucidated. The study aimed to determine whether uric acid could reduce end points associated with nonsteroidal anti‐inflammatory drug (NSAID)‐induced enteropathy.MethodsA mouse model of NSAID‐induced enteropathy was generated by administering indomethacin intraperitoneally to 8‐week‐old male C57BL/6 mice, and then vehicle or uric acid was administered orally. A group of mice treated with indomethacin was also concurrently administered inosinic acid, a uric acid precursor, and potassium oxonate, an inhibitor of uric acid metabolism, intraperitoneally. For in vitro analysis, Caco‐2 cells treated with indomethacin were incubated in the presence or absence of uric acid.ResultsOral administration of uric acid ameliorated NSAID‐induced enteropathy in mice even though serum uric acid levels did not increase. Intraperitoneal administration of inosinic acid and potassium oxonate significantly elevated serum uric acid levels and ameliorated NSAID‐induced enteropathy in mice. Both oral uric acid treatment and intraperitoneal treatment with inosinic acid and potassium oxonate significantly decreased lipid peroxidation in the ileum of mice with NSAID‐induced enteropathy. Treatment with uric acid protected Caco‐2 cells from indomethacin‐induced oxidative stress, lipid peroxidation, and cytotoxicity.ConclusionsUric acid within the intestinal lumen and in serum had a protective effect against NSAID‐induced enteropathy in mice, through its antioxidant activity. Uric acid could be a promising therapeutic target for NSAID‐induced enteropathy.
Brefeldin A sensitive mechanisms contribute to endocytotic membrane retrieval and vesicle recycling in cerebellar granule cells
Authors: Rampérez Alberto , Sánchez‐Prieto José , Torres Magdalena 
Published: March 2017

AbstractThe recycling of synaptic vesicle (SV) proteins and transmitter release occur at multiple sites along the axon. These processes are sensitive to inhibition of the small GTP binding protein ARF1, which regulates the adaptor protein 1 and 3 complex (AP‐1/AP‐3). As the axon matures, SV recycling becomes restricted to the presynaptic bouton, and its machinery undergoes a complex process of maturation. We used the styryl dye FM1‐43 to highlight differences in the efficiency of membrane recycling at different sites in cerebellar granule cells cultured for 7 days in vitro. We used Brefeldin A (BFA) to inhibit AP‐1/AP‐3‐mediated recycling and to test the contribution of this pathway to the heterogeneity of the responses when these cells are strongly stimulated. Combining imaging techniques and ultrastructural analyses, we found a significant decrease in the density of functional boutons and an increase in the presence of endosome‐like structures within the boutons of cells incubated with BFA prior to FM1‐43 loading. Such effects were not observed when BFA was added 5 min after the end of the loading step, when endocytosis was almost fully completed. In this situation, vesicles were found closer to the active zone (AZ) in boutons exposed to BFA. Together, these data suggest that the AP‐1/AP‐3 pathway contributes to SV recycling, affecting different steps in all boutons but not equally, and thus being partly responsible for the heterogeneity of the different recycling efficiencies.
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Cover Image for this issue: doi. 10.1111/jnc.13801.
CRIP1a inhibits endocytosis of G‐protein coupled receptors activated by endocannabinoids and glutamate by a common molecular mechanism
Authors: Mascia Fabrizio , Klotz Lisa , Lerch Judith , Ahmed Mostafa H. , Zhang Yan , Enz Ralf 
Published: March 2017

AbstractThe excitability of the central nervous system depends largely on the surface density of neurotransmitter receptors. The endocannabinoid receptor 1 (CB1R) and the metabotropic glutamate receptor mGlu8R are expressed pre‐synaptically where they reduce glutamate release into the synaptic cleft. Recently, the CB1R interacting protein cannabinoid receptor interacting protein 1a (CRIP1a) was identified and characterized to regulate CB1R activity in neurons. However, underlying molecular mechanisms are largely unknown. Here, we identified a common mechanism used by CRIP1a to regulate the cell surface density of two different types of G‐protein coupled receptors, CB1R and mGlu8aR. Five amino acids within the CB1R C‐terminus were required and sufficient to reduce constitutive CB1R endocytosis by about 72% in the presence of CRIP1a. Interestingly, a similar sequence is present in mGlu8aR and consistently, endocytosis of mGlu8aR depended on CRIP1a, as well. Docking analysis and molecular dynamics simulations identified a conserved serine in CB1R (S468) and mGlu8aR (S894) that forms a hydrogen bond with the peptide backbone of CRIP1a at position R82. In contrast to mGlu8aR, the closely related mGlu8bR splice‐variant carries a lysine (K894) at this position, and indeed, mGlu8bR endocytosis was not affected by CRIP1a. Chimeric constructs between CB1R, mGlu8aR, and mGlu8bR underline the role of the identified five CRIP1a sensitive amino acids. In summary, we suggest that CRIP1a negatively regulates endocytosis of two different G‐protein coupled receptor types, CB1R and mGlu8aR.
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Contributing factors for therapeutic diet adherence in patients receiving haemodialysis treatment: an integrative review
Authors: Oquendo Lissete González , Asencio José Miguel Morales , de las Nieves Candela Bonill 
Published: March 2017

Aims and objectivesThe objective of this integrative review is to identify the factors that contribute to diet adherence in people suffering from kidney disease who are receiving haemodialysis treatment.BackgroundAdherence to the therapeutic regimen determines therapeutic success, quality of life and survival in patients on haemodialysis. Lack of diet adherence ranges from 25%–86% in patients receiving haemodialysis treatment and affects patient morbidity and mortality.DesignAn integrative literature review was conducted based on the criteria of Whittemore & Knafl.MethodsA literature review was performed by two members of the team using twelve databases including PubMed, CUIDEN, CINAHL, The Cochrane Library and ScienceDirect.ResultsThe main issues identified after analysing the results were as follows: the intrinsic barriers (age, dialysis time, motivation, perceived benefit, distorted perception of adherence) and facilitators (self‐efficacy, perception of disease, perception of control), extrinsic barriers (family dysfunction, lack of social support, cultural patterns of consumption of food) and facilitators (social support, relationship with healthcare providers), and interventions to encourage diet adherence, such as the use of motivational interviewing in educational interventions, and the training and education of relevant professionals in communication skills.ConclusionsDiet nonadherence remains a serious health problem and suffers from a lack of solid criteria to identify this condition. The onset of depression signs and the level of social support available to the patient should be assessed, because these are important factors that determine adherence to treatment.Relevance to Clinical PracticeProfessionals should be trained in health education and communication techniques to contribute to the patient's self‐management and motivation for diet adherence. Controlled and randomised clinical studies involving predialysis stages should be performed to investigate the impact of the assessment and control of barriers to diet adherence.
Reference gene selection for reverse transcription quantitative polymerase chain reaction in chicken hypothalamus under different feeding status
Authors: Simon Á. , Jávor A. , Bai P. , Oláh J. , Czeglédi L. 
Published: March 2017

SummaryThis study was designed to investigate the stability of 10 candidate reference genes, namely ACTB, B2M, GAPDH, HMBS, LBR, POLR2B, RN18S, RPS17, TBP, and YWHAZ for the normalization of gene expression data obtained by quantitative real‐time polymerase chain reaction (qPCR) in studies related to feed intake of chicken. Samples were isolated from hypothalamus under three different nutritional status (ad libitum, fasted for 24 hr, fasted for 24 hr then refed for 2 hr). Five different algorithms were applied for the analysis of reference gene stability: BestKeeper, geNorm, NormFinder, the comparative ΔCt method, and a novel approach using multivariate linear mixed‐effects modelling for stable reference gene selection. TBP and POLR2B were identified as the two most suitable and B2M and RN18S as the two least stable reference genes for normalization. Despite our review, the current literature showing that RN18S is one of the most commonly used reference gene in chicken gene expression studies, its applicability for normalization should be evaluated before each qPCR experiment.
Vasoactive effect of fibronectin‐derived epiviosamine‐1 and related peptides in quiescent and stress models
Authors: Frame Mary D. , Lin Fubao , Dewar Anthony M. , Clark Richard A. F. 
Published: March 2017

AbstractObjectiveFollowing thermal burn injury, plasma fibronectin degrades within the interstitium; one possible product is EVA‐1, PSHISKYILRWRPK found within the FNIII1. EVA‐1 ameliorates thermal burn injury progression, and binds to and enhances PDGF‐BB in promoting cell metabolism, growth and survival; shorter related peptides lose these abilities. Here we study the effect of EVA‐1 and shorter peptides for their vasoactivity under quiescent and stress conditions.MethodsUsing the hamster cheek pouch intravital microscopy model, five EVA‐1 related peptides were applied to small arterioles via micropipette (10−16‐10−4mol L−1) in quiescent tissue and after defined stress: nitric oxide or heat.ResultsPeak dilation occurred with nanomolar doses (longer peptides) or below (shorter peptides), blocked by propranolol (beta‐adrenergic receptor antagonist). Micromolar doses of the same peptides induced only constriction, not antagonized by phentolamine (alpha‐adrenergic receptor antagonist). Scrambled variants of two peptides yielded only constriction, suggesting constriction might be due peptide charge. Each stressor caused a left shift in dilation response, blocked by carazolol.ConclusionsThus, this important region of FNIII1 contains sequences that have a gradation of biological functions dependent on the length of the peptide sequence, with increased efficacy for dilation following stressors.
Lymphomatosis cerebri showing transient spontaneous regression
Authors: Inamasu Joji , Nishimoto Masaaki , Kitamura Yohei , Mayanagi Keita , Nakatsukasa Masashi , Yoshii Masami , Oshima Takeo , Tomiyasu Kazuhiro 
Published: March 2017

AbstractWe describe the case of a 35‐year‐old man who presented with a seizure. Brain magnetic resonance imaging showed multiple white matter lesions in the cerebral hemispheres. His seizure was controllable with antiepileptics, and he remained asymptomatic for the next 4 months with follow‐up magnetic resonance imaging showing transient spontaneous regression. However, he developed progressive decline in cognitive functions approximately 1 year after symptom onset. Magnetic resonance imaging showed recurrence of the white matter lesions and progression of brain atrophy. A brain biopsy established the pathological diagnosis of diffuse large B‐cell lymphoma, and he was clinically diagnosed with lymphomatosis cerebri. Lymphomatosis cerebri is a rare variant of primary central nervous system lymphoma characterized by diffuse infiltration of lymphomatous cells into the brain without forming a cohesive tumor mass. Although the clinical and radiographic course is rapidly progressive in the great majority of patients with lymphomatosis cerebri, transient spontaneous regression can occur, posing diagnostic challenges for physicians.
Timing of diapause termination in relation to variation in winter climate
Authors: Lehmann Philipp , Van Der Bijl Wouter , Nylin Sören , Wheat Christopher W. , Gotthard Karl 
Published: March 2017

AbstractIn temperate insects, winters are typically endured by entering diapause, which comprises a deep resting stage. Correct timing of diapause termination is vital for synchronization of emergence with conspecifics and for mobilizing resources when conditions for growth and reproduction become favourable. Although critical to survival, the intrinsic and extrinsic drivers of diapause termination timing are poorly understood. In the present study, we investigate diapause development under a range of durations (10–24 weeks) spent at different temperatures (−2 to 10 °C) in the pupal diapausing butterfly Pieris napi Linnaeus (Lepidoptera:Pieridae). We determine: (i) the maximum cold temperature for diapause development; (ii) if pupae in diapause count cold days or cold sums; and (iii) whether diapause termination is distinct or gradual. The results indicate large and idiosyncratic effects of high and low nonlethal temperatures on diapause development in P. napi. Although all temperatures tested lead to diapause termination, a thermal optimum between 2 and 4 °C is observed. Lower temperatures lead to decreased eclosion propensity, whereas higher temperatures slow down development and increase emergence desynchronization. These data suggest that, rather than a simple cold‐summing process with a distinct diapause termination point, there are trade‐offs between time and temperature at the low and high end of the thermal range, resulting in a nonlinear thermal landscape showing a ridge of increasing eclosion propensity at moderate temperatures. The present study suggests that the effects of temperature on diapause development should be included in projections on post‐winter phenology models of insects, including pest species.
Photochemical Immobilization of Polymers on a Surface: Controlling Film Thickness and Wettability
Authors: Carroll Gregory T. , Turro Nicholas J. , Mammana Angela , Koberstein Jeffrey T. 
Published: March 2017

AbstractIn this manuscript, we demonstrate the control of film thickness and surface wettability in the photochemical immobilization of poly (vinyl alcohol) (PVA) to a self‐assembled monolayer (SAM) containing a phthalimide chromophore. Surface attachment is characterized by ellipsometry and contact angle measurements. The wettability of the resulting films is shown to depend on the chemical composition of the polymer. The film thickness is shown to depend on the irradiation time and molecular weight of the polymer. Using a photomask, micropatterns of polymers can be grafted to the SAM. The photopatterned surface can be “developed” by coating with a thin layer of a mixture containing poly (styrene) (PS) and triphenylsulfonium triflate.
Frontal EEG asymmetry during symptom provocation predicts subjective responses to intrusions in survivors with and without PTSD
Authors: Meyer Thomas , Quaedflieg Conny W. E. M. , Weijland Kim , Schruers Koen , Merckelbach Harald , Smeets Tom 
Published: March 2017

AbstractStudies suggest that frontal alpha asymmetry is closely linked to psychological adjustment following stressful experiences, such that more left‐sided frontal activation during symptom provocation might predict lower levels of posttraumatic stress disorder (PTSD). Here, we tested whether frontal asymmetry at rest and during exposure to neutral, positive, negative, and trauma‐related images would be associated with PTSD, and particularly with characteristic reexperiencing symptoms. Symptoms were assessed in trauma victims with (n = 24) and without PTSD (n = 15), using both retrospective measures and 1‐week ambulatory assessments with a diary and a smartphone. While resting frontal asymmetry was unrelated to all retrospective measures, left‐sided activation in response to the negative picture correlated with lower levels of psychopathology. Left‐sided activation in the trauma‐related picture condition was more specifically associated with less emotionally intense intrusions and responses to viewing the picture, even when corrected for other symptoms of psychopathology. These effects tended to increase when participants with possible overreporting tendencies were removed from the analyses. Moreover, trauma victims without PTSD (i.e., relatively more resilient individuals) displayed higher left‐sided frontal activation in response to the negative picture, also when compared with a third group of healthy, trauma‐free individuals (n = 15). Our findings suggest that state‐dependent changes in frontal asymmetry could serve as a biological marker of PTSD symptoms and could eventually be used for diagnostic purposes or as a target for neuromodulation interventions. Future studies should establish whether this marker can serve as an early predictor of psychopathology in recently traumatized individuals.