bluuebunny/crossref_metadata_2025_split huggingface dataset:
Volume-based structural connectome of epilepsy partialis continua in Rasmussen’s encephalitis
Authors: Fu Cong , Yang Xue , Wang Mengyang , Wang Xiongfei , Tang Chongyang , Luan Guoming 
Published: September 2024

Abstract
Rasmussen's encephalitis is a rare, progressive neurological inflammatory with hemispheric brain atrophy. Epilepsy partialis continua (EPC) is a diagnostic clinical condition in patients with Rasmussen's encephalitis. However, the incidence of EPC in the natural course of Rasmussen's encephalitis is only about 50%. The majority of experts hold the belief that EPC is associated with dysfunction in the motor cortex, yet the whole pathogenesis remains unclear. We hypothesize that there is a characteristic topological discrepancy between groups with EPC and without EPC from the perspective of structural connectome. To this end, we described the structural MRI findings of 20 Rasmussen's encephalitis cases, 11 of which had EPC, and 9 of which did not have EPC (NEPC), and 20 healthy controls. We performed voxel-based morphometry to evaluate the alterations of grey matter volume. Using a volume-based structural covariant network, the hub distribution and modularity were studied at the group level. Based on the radiomic features, an individual radiomics structural similarity network was constructed for global topological properties, such as small-world index, higher path length, and clustering coefficient. And then, the Pearson correlation was used to delineate the association between duration and topology properties. In the both EPC and NEPC groups, the volume of the motor cortex on the affected side was significantly decreased, but putamen atrophy was most pronounced in the EPC group. Hubs in the EPC group consisted of the executive network, and the contralateral putamen was the hub in the NEPC group with the highest betweenness centrality. Compared to the NEPC, the EPC showed a higher path length and clustering coefficient in the structural similarity network. Moreover, the function of morphological network integration in EPC patients was diminished as the duration of Rasmussen's encephalitis increased. Our study indicates that motor cortex atrophy may not be directly related to EPC patients. Whereas atrophy of the putamen, and a more regularized configuration may contribute to the generation of EPC. The findings further suggest that the putamen could potentially serve as a viable target for controlling EPC in patients with Rasmussen's encephalitis.
Cortisol in fish scales remains stable during extended periods of storage
Authors: O’Toole Christina , White Philip , Graham Conor T , Conroy Caitlin , Brophy Deirdre 
Published: September 2024

Abstract
Measurement of cortisol in fish scales is attracting considerable attention as a non-invasive indicator of chronic stress in wild populations. For many fish species of management and conservation interest, extensive scale collections exist that could provide extended records of individual stress responses, by combining cortisol measurements with life history information. However, it is not yet known how well cortisol is preserved in the scale during storage. To investigate the stability of scale cortisol, we accelerated potential degradation by storing scales from an individual farmed Atlantic salmon (Salmo salar) in an oven at 50°C for between 2 and 12 weeks. We found no significant relationship between scale cortisol concentration and either storage time or storage temperature. Cortisol concentrations in scales from the same fish were consistent (18.54–21.82 ng. g−1; coefficient of variation (CV) = 3.6%), indicating that scale cortisol can be reliably quantified, even in scales stored for varying periods of time or under different conditions. We also examined the effects of storage in real time using Atlantic salmon scales that were stored in paper envelopes at room temperature for between 3 and 32 years and found no significant relationship between scale cortisol concentration and storage time. Scale cortisol concentrations ranged from 4.05 to 135.37 ng.g−1 and levels of between-individual variability were high (CV = 61%). Given that scale cortisol does not degrade during long-term storage, historical scale collections and associated data describing fish life histories could potentially be used to develop bioindicators of physiological responses in fish populations. Further research is needed to understand scale cortisol variability and its biological relevance.
A shrapnel migration from a peripheral vein to the right ventricle: case report
Authors: Sharony Ram , Statlender Liran , Shapira Yaron , Vaturi Mordehay , Tamir Shlomit 
Published: September 2024

Abstract

Background
Foreign bodies that migrate into the heart may include medical devices dislodged from their original location or, rarely, external particles (shrapnel and other foreign bodies) that penetrate the vein, remain intraluminal, and migrate via the venous blood flow to the right heart. Most reported entry sites of these external foreign bodies were in the torso, thigh, or neck; none of them penetrated through a distal extremity of the body. We report a case where shrapnel was found in the right ventricle (RV) following penetrating injury to the hand.

Case summary
An otherwise healthy 24-year-old man presented with an isolated shrapnel injury to his right hand and forearm from an explosion trauma. Computed tomography demonstrated multiple small metal objects in the forearm, hand, and wrist. Additionally, a 3 × 3.5 mm metal object was found in the RV, consistent with a metal shrapnel embolus from the forearm. Echocardiography indicated the fragment to be in a fixed position within the RV, without any additional pathology.

Discussion
Even shrapnel that penetrates through the hand or forearm may migrate to the heart. In this case, following a multidisciplinary discussion, a conservative approach was recommended based on the following condition: lack of symptoms, small size of the foreign body, no obstruction of venous effluent, low risk of significant embolization to the pulmonary vasculature, absence of fever or endocarditis, no current evidence or risk of valve dysfunction, and no myocardial irritation indicated by arrhythmia. The patient was instructed to avoid magnetic resonance imaging scans.
Performance of D-dimer, cardiac troponin T, C-reactive protein, and NT-proBNP in prediction of long-term mortality in patients with suspected pulmonary embolism
Authors: Kauppi Juha , Airaksinen K E Juhani , Lehto Joonas , Pouru Jussi-Pekka , Saha Juuso , Purola Petra , Jaakkola Samuli , Lehtonen Jarmo , Vasankari Tuija , Juonala Markus , Kiviniemi Tuomas 
Published: September 2024

Abstract

Aims
Pulmonary embolism (PE) is a common and potentially life-threatening condition requiring emergent diagnostic work-up. Despite wide use of biomarkers, little is known how they predict long-term prognosis of patients evaluated for suspected PE.

Methods and results
We sought to assess the predictive performance of N-terminal pro-brain natriuretic peptide (NT-proBNP), C-reactive protein, fibrin D-dimer (FIDD), and cardiac troponin T (cTnT) in patients who underwent computed tomography pulmonary angiography (CTPA) for clinical suspicion of PE. The analysis involved 1001 patients, with 222 (22.2%) receiving a PE diagnosis at index imaging. Mean ages of patients with and without PE were 65.0 ± 17.1 and 64.5 ± 17.7 years, respectively. Median follow-up time was 3.9 years (interquartile range 2.9–4.9). Mortality was relatively high among both patients with and without documented PE (24.8% vs. 31.7%, P = 0.047). In patients with PE, only elevated NT-proBNP &gt; 1000 ng/L and C-reactive protein &gt; 50 mg/L levels at hospital admission were associated with higher mortality in an adjusted Cox regression model, but receiver operating characteristic (ROC) analysis showed no improved prediction compared to clinical variables. Among patients without PE, elevated NT-proBNP &gt; 1000 ng/L, C-reactive protein &gt; 10 mg/L, cTnT &gt; 50 ng/L, and FIDD &gt; 1.0 mg/L all predicted mortality. In an ROC analysis among patients without PE, models including NT-proBNP, cTnT, or C-reactive protein provided improved predictive performance.

Conclusion
Patients evaluated for clinical suspicion of PE have high long-term mortality. Commonly used biomarkers provide long-term prognostic value in patients without PE. Given the relatively young age, it is vital to identify these high-risk patients and perform differential diagnosis work-up for alternative life-threatening conditions, and manage them as appropriate.
Simple endoscopic estimation to predict anastomotic complications after bronchoplastic procedures
Authors: Fukui Mariko , Suzuki Kenji , Imashimizu Kota , Ichikawa Tomohiro , Matsunaga Takeshi , Hattori Aritoshi , Tomita Hisashi , Takamochi Kazuya 
Published: September 2024

Abstract

OBJECTIVES
Endoscopic evaluation of anastomosis is effective for the early detection of anastomotic complications after a bronchoplastic procedure. Herein, we aimed to clarify important findings for predicting anastomotic complications.

METHODS
This single-centre retrospective study included patients who underwent bronchoplastic surgery between April 2013 and September 2023. Only cases in which bronchoscopy was performed both 1 and 2 weeks after surgery were included. Endoscopic findings (classification by Ludwig and Stoelben, mucosa colour, oedema, slough area and colour and depression) were reviewed for all cases. The accuracy of these findings for predicting anastomotic complications was evaluated.

RESULTS
Of the 190 patients included in this study, 14 (7.4%) experienced anastomotic abnormalities, 11 had fistulas (5.8%) and 7 had stenosis (3.7%). The onsets of fistula and stenosis were 20–28 and 20–44 days after surgery, respectively. In 102 patients (53.7%), the slough worsened from the first to the second week postsurgery. Therefore, it was easier to evaluate slough 2 weeks postsurgery rather than 1-week postsurgery. The positive/negative predicted values of anastomotic complications in endoscopic findings 2 weeks postsurgery were circular slough, 34.2%/99.3%; slough with dark colour, 39.3%/98.1%; and depression, 54.2%/99.4%. The incidence of anastomotic abnormalities was 0% in cases without the 3 findings, 10% in cases with at least 1 finding and 67% in cases with all 3 findings.

CONCLUSIONS
The endoscopic findings of slough on the anastomosis 2 weeks after bronchoplasty can be easily evaluated and accurately predict complications. Three important endoscopic findings were circular slough, dark colour and depression.
How learning about harms impacts the optimal rate of artificial intelligence adoption
Authors: Gans Joshua S 
Published: September 2024

SUMMARY
This paper examines recent proposals and research suggesting that artificial intelligence (AI) adoption should be delayed until its potential harms are fully understood. Conclusions on the social optimality of delayed AI adoption are shown to be sensitive to assumptions about the process by which regulators learn about the salience of particular harms. When such learning is by doing – based on the real-world adoption of AI – this generally favours acceleration of AI adoption to surface and react to potential harms more quickly. This case is strengthened when AI adoption is potentially reversible. This paper examines how different conclusions regarding the optimality of accelerated or delayed AI adoption influence and are influenced by other policies that may moderate AI harm.
Prognostic value of ventricular arrhythmia in early post-infarction left ventricular dysfunction: the French nationwide WICD-MI study
Authors: Echivard Mathieu , Sellal Jean-Marc , Ziliox Chloé , Marijon Eloi , Bordachar Pierre , Ploux Sylvain , Benali Karim , Marquié Christelle , Docq Clémence , Klug Didier , Eschalier Romain , Maille Baptiste , Deharo Jean-Claude , Babuty Dominique , Genet Thibaud , Gandjbakhch Estelle , Da Costa Antoine , Piot Olivier , Minois Damien , Gourraud Jean-Baptiste , Mondoly Pierre , Maury Philippe , Boveda Serge , Pasquié Jean-Luc , Martins Raphaël , Leclercq Christophe , Guenancia Charles , Laurent Gabriel , Becker Mathieu , Bertrand Julien , Chevalier Philippe , Manenti Vladimir , Kubala Maciej , Defaye Pascal , Jacon Peggy , Desbiolles Antoine , Badoz Marc , Jesel Laurence , Lellouche Nicolas , Milliez Paul-Ursmar , Ollitrault Pierre , Fareh Samir , Bercker Matthieu , Mansourati Jacques , Guy-Moyat Benoît , Chabert Jean-Pierre , Luconi Nicolas , Winum Pierre-François , Anselme Frédéric , Extramiana Fabrice , Delahaye Camille , Jourda François , Bizeau Olivier , Nasarre Mathieu , Olivier Arnaud , Fromentin Stéphane , Villemin Thibault , Levavasseur Olivier , Hammache Néfissa , Magnin-Poull Isabelle , Blangy Hugues , Sadoul Nicolas , Duarte Kevin , Girerd Nicolas , de Chillou Christian 
Published: September 2024

Abstract

Background and Aims
Prophylactic implantable cardioverter–defibrillators (ICDs) are not recommended until left ventricular ejection fraction (LVEF) has been reassessed 40 to 90 days after an acute myocardial infarction. In the current therapeutic era, the prognosis of sustained ventricular arrhythmias (VAs) occurring during this early post-infarction phase (i.e. within 3 months of hospital discharge) has not yet been specifically evaluated in post-myocardial infarction patients with impaired LVEF. Such was the aim of this retrospective study.

Methods
Data analysis was based on a nationwide registry of 1032 consecutive patients with LVEF ≤ 35% after acute myocardial infarction who were implanted with an ICD after being prescribed a wearable cardioverter–defibrillator (WCD) for a period of 3 months upon discharge from hospital after the index infarction.

Results
ICDs were implanted either because a sustained VA occurred while on WCD (VA+/WCD, n = 72) or because LVEF remained ≤35% at the end of the early post-infarction phase (VA−/WCD, n = 960). The median follow-up was 30.9 months. Sustained VAs occurred within 1 year after ICD implantation in 22.2% and 3.5% of VA+/WCD and VA−/WCD patients, respectively (P &lt; .0001). The adjusted multivariable analysis showed that sustained VAs while on WCD independently predicted recurrence of sustained VAs at 1 year (adjusted hazard ratio [HR] 6.91; 95% confidence interval [CI] 3.73–12.81; P &lt; .0001) and at the end of follow-up (adjusted HR 3.86; 95% CI 2.37–6.30; P &lt; .0001) as well as 1-year mortality (adjusted HR 2.86; 95% CI 1.28–6.39; P = .012).

Conclusions
In patients with LVEF ≤ 35%, sustained VA during the early post-infarction phase is predictive of recurrent sustained VAs and 1-year mortality.
Oral Health Problems Among Flemish and Dutch Nursing Home Residents Assessed by Nondental Caregivers Using the Novel Oral Health Section for Inclusion in interRAI
Authors: Schoebrechts Emilie , de Almeida Mello Johanna , Vandenbulcke Patricia A I , Palmers Ellen E , van Hout Hein P J , De Lepeleire Jan , Declercq Anja , Declerck Dominique , Duyck Joke 
Published: September 2024

Abstract

Background and Objectives
Oral health of older adults in nursing homes is poor, which can negatively affect general health and well-being. Most oral health problems are preventable with good oral hygiene and regular dental check-ups. Caregivers can help improve residents’ oral health through regular oral health assessments. The interRAI instrument used in Long-Term Care Facilities to evaluate older adults’ health and well-being, has the potential to integrate oral care into general care planning. The recently optimized Oral Health Section for inclusion in the interRAI instruments (OHS-interRAI) enables nondental caregivers to identify residents requiring help with oral hygiene and/or a dental referral. This study reports the first data obtained using the OHS-interRAI, describing the oral health situation of older adults in Flemish and Dutch nursing homes.

Research Design and Methods
In this cross-sectional study, interRAI Long-Term Care Facilities data, including OHS-interRAI data, were collected from October 2020 to January 2023 and analyzed from 417 and 795 persons aged 65 years or older in Flemish and Dutch nursing homes, respectively.

Results
Most common oral health problems were poor oral hygiene and compromised teeth. Differences in oral health were found between Flemish and Dutch residents. Flemish residents had significantly more problems with chewing, dry mouth, oral and denture hygiene, and tongue condition than their Dutch counterparts. They also had a higher need for help with oral hygiene (19.4% vs 14.0%), and a dental referral (36.8% vs 20.9%). Older adults in Flemish nursing homes (20.3%) had significantly fewer dental check-ups than those in Dutch nursing homes (73.5%).

Discussion and Implications
The use of the OHS-interRAI by nondental caregivers identified at least one-third of the residents requiring help with oral hygiene and/or a dental referral. By means of trigger algorithms (Collaborative Action Points), the OHS-interRAI enables the integration of oral care into general care planning.
Safety of Rotavirus Vaccination in Infants That Were Exposed to Biologics In Utero: A Systematic Review
Authors: Schell Trevor L , Fass Lucas , Hitchcock Mary E , Farraye Francis A , Hayney Mary S , Saha Sumona , Caldera Freddy 
Published: September 2024

Abstract

Background
In infants that were exposed to biologics in utero, gastroenterology societal guidelines have either recommended against administration of the live rotavirus vaccine until 6-12 months of age or until serum biologic levels are undetectable. We performed a systematic review to evaluate the safety of rotavirus vaccination in biologic-exposed infants.

Methods
EMBASE, PubMed, Scopus, and Cochrane databases were searched from 2006 to 2024 for original data reporting on the safety of rotavirus vaccination in infants that were exposed to anti-tumor necrosis factors (TNFs) (ie, infliximab, adalimumab, golimumab, certolizumab) and non-TNF biologics (ie, vedolizumab, ustekinumab, rizankizumab, mirikizumab) in utero.

Results
A database search yielded 7185 screening results of which 10 studies met inclusion criteria. There were over 300 instances of rotavirus vaccination in biologic-exposed infants (n = 162 exposed to anti-TNFs, n = 142 exposed to non-TNF biologics). Biologic-exposed infants were not at an increased risk of severe adverse events or adverse events of any severity related to rotavirus vaccination.

Conclusions
Administration of the live rotavirus vaccine appears to be safe in biologic-exposed infants. As such, with careful examination of the risks and benefits, there may be a role for rotavirus vaccination in this population.
A Geometric Approach to Feigin–Loktev Fusion Product and Cluster Relations in Coherent Satake Category
Authors: Dumanski Ilya 
Published: September 2024

Abstract
We propose a geometric realization of the Feigin–Loktev fusion product of graded cyclic modules over the current algebra. This allows us to compute it in several new cases. We also relate the Feigin–Loktev fusion product to the convolution of perverse coherent sheaves on the affine Grassmannian of the adjoint group. This relation allows us to establish the existence of exact triples, conjecturally corresponding to cluster relations in the Grothendieck ring of coherent Satake category.
The Chilean Constitutional Convention: An Exercise for the Pluriverse
Authors: Delucchi Adriana Suárez 
Published: September 2024

Abstract
Neoliberal principles were codified in a constitution and implemented during a right-wing military dictatorship (1973–1990) in Chile producing important social inequalities, as well as cultural and ecological destruction. Resistance against the arrangements inherited from that period and deepened thereafter has been paramount to recent politics. In October 2019, considerable street protests were institutionally channeled into a constitutional process where a referendum was mandated to replace the dictatorship’s constitution. There were two attempts to write a new charter: one under a Constitutional Convention that took a decolonial character, and a second one dominated by a far-right council. Drawing on Loughlin’s “constitutional imagination,” the article poses that the Convention was a world-making exercise where social movements, independent candidates, Indigenous representatives, and their allies engaged in efforts for designing a pluriverse where many worlds could fit. I claim the Convention was a space where utopia and ideology met allowing for different worlds to work together for the first time in the political arena creating an incipient intercultural politics. As a text with world-making capacity, the draft from the Convention, although rejected in 2022, materializes a process from which stronger intersectional solidarity among feminist, Indigenous, and ecological movements should be forged.
Deciphering the spatial distribution of Gli1-lineage cells in dental, oral, and craniofacial regions
Authors: Li Bo , Ding Zhangfan , Ouchi Takehito , Liao Yueqi , Li Bingzhi , Gong Jiajing , Xie Yuhang , Zhao Zhihe , Li Longjiang 
Published: September 2024

Abstract
The craniofacial bone, crucial for protecting brain tissue and supporting facial structure, undergoes continuous remodeling through mesenchymal (MSCs) or skeletal stem cells in their niches. Gli1 is an ideal marker for labeling MSCs and osteoprogenitors in this region, and Gli1-lineage cells are identified as pivotal for bone growth, development, repair, and regeneration. Despite its significance, the distribution of Gli1-lineage cells across the dental, oral, and craniofacial (DOC) regions remains to be systematically explored. Utilizing tissue-clearing and light sheet fluorescence microscopy with a Gli1CreER; tdTomatoAi14 mouse model, we mapped the spatial distribution of Gli1-lineage cells throughout the skull, focusing on calvarial bones, sutures, bone marrow, teeth, periodontium, jaw bones, and the temporomandibular joint. We found Gli1-lineage cells widespread in these areas, underscoring their significance in DOC regions. Additionally, we observed their role in repairing calvarial bone defects, providing novel insights into craniofacial biology and stem cell niches and enhancing our understanding of stem cells and their progeny’s behavior in vivo.
Interferon-gamma induces epithelial reprogramming driving CXCL11-mediated T-cell migration
Authors: Cutilli Alessandro , Jansen Suze A , Paolucci Francesca , van Hoesel Marliek , Frederiks Cynthia L , Mulder Tessa A M , Chalkiadakis Theofilos , Mokry Michal , Prekovic Stefan , Mocholi Enric , Lindemans Caroline A , Coffer Paul J 
Published: September 2024

Abstract
The cytokine interferon-gamma plays a multifaceted role in intestinal immune responses ranging from anti- to proinflammatory depending on the setting. Here, using a 3D co-culture system based on human intestinal epithelial organoids, we explore the capacity of interferon-gamma exposure to reprogram intestinal epithelia and thereby directly modulate lymphocyte responses. Interferon-gamma treatment of organoids led to transcriptional reprogramming, marked by a switch to a proinflammatory gene expression profile, including transcriptional upregulation of the chemokines CXCL9, CXCL10, and CXCL11. Proteomic analysis of organoid-conditioned medium posttreatment confirmed chemokine secretion. Interferon-gamma treatment of organoids led to enhanced T-cell migration in a CXCL11-dependent manner without affecting T-cell activation status. Taken together, our results suggest a specific role for CXCL11 in T-cell recruitment that could be targeted to prevent T-cell trafficking to the inflamed intestine.