bluuebunny/crossref_metadata_2025_split huggingface dataset:
p‐Coumaric acid, a dietary polyphenol ameliorates inflammation and curtails cartilage and bone erosion in the rheumatoid arthritis rat model
Authors: Neog Manoj Kumar , Joshua Pragasam Samuel , Krishnan Moorthy , Rasool Mahaboobkhan 
Published: July 2017

AbstractThis study was designed to explore the underlying mechanism of p‐coumaric acid (CA), a dietary polyphenol in adjuvant‐induced arthritis (AIA) rat model with reference to synovitis and osteoclastogenesis. Celecoxib (COX‐2 selective inhibitor) (5 mg/kg b.wt) was used as a reference drug. CA remarkably suppressed the paw edema, body weight loss and inflammatory cytokine and chemokine levels (TNF‐α, IL‐1β, IL‐6, and MCP‐1) in serum and ankle joint of arthritic rats. Consistently, CA reduced the expression of osteoclastogenic factors (RANKL and TRAP), pro‐inflammatory cytokines (TNF‐α, IL‐1β, IL‐6, and IL‐17), and inflammatory enzymes (iNOS and COX‐2) in arthritic rats. However, OPG expression was found elevated. Besides, the abundance of transcription factors (NF‐κB‐p65, and p‐NF‐κB‐p65, NFATc‐1, and c‐Fos) and MAP kinases (JNK, p‐JNK, and ERK1/2) expression was alleviated in CA administered arthritic rats. In addition, CA truncated osteoclastogenesis by regulating the RANKL/OPG imbalance in arthritic rats and suppressing the RANKL‐induced NFATc‐1 and c‐Fos expression in vitro. Radiological (CT and DEXA scan) and histological assessments authenticated that CA inhibited TRAP, bone destruction and cartilage degradation in association with enhanced bone mineral density. Taken together, our findings suggest that CA demonstrated promising anti‐arthritic effect and could prove useful as an alternative drug in RA therapeutics. © 2017 BioFactors, 43(5):698–717, 2017
MiR‐376a suppresses the proliferation and invasion of non‐small‐cell lung cancer by targeting c‐Myc
Authors: Wang Youyu , Cong Wei , Wu Gang , Ju Xueming , Li Zhixi , Duan Xin , Wang Xueli , Gao Hong 
Published: July 2017

AbstractIt has been reported that miR‐376a is involved in the formation and progression of several types of cancer. However, the expression and function of miR‐376a is still unknown in non‐small cell lung carcinomas (NSCLC). In this study, the expression of miR‐376a in NSCLC tissues and cell lines were examined by real‐time PCR, the effects of miR‐376a on cell proliferation, apoptosis and invasion were evaluated in vitro. Luciferase reporter assay was performed to identify the targets of miR‐376a. The results showed that miR‐376a was significantly downregulated in NSCLC tissues and cell lines. Restoration of miR‐376a in NSCLC cell line A549 significantly inhibited cell proliferation, increased cell apoptosis and suppressed cell invasion, compared with control‐transfected A549 cells. Luciferase reporter assay showed that c‐Myc, an oncogene that regulating cell survival, angiogenesis and metastasis, was a direct target of miR‐376a. Over‐expression of miR‐376a decreased the mRNA and protein levels of c‐Myc in A549 cells. In addition, upregulation of c‐Myc inhibited miR‐376a‐induced inhibition of cell proliferation and invasion in A549 cells. Therefore, our results indicate a tumor suppressor role of miR‐376a in NSCLC by targeting c‐Myc. miR‐376a may be a promising therapeutic target for NSCLC.
Salvage of an osteocutaneous thermonecrosis secondary to tibial reaming by the induced membrane procedure
Authors: Cambon‐Binder Adeline , Revol Marc , Hannouche Didier 
Published: July 2017

Key Clinical MessageOsteocutaneous thermonecrosis is a rare but devastating complication of tibial reaming, which can cause large and infected bone and cutaneous defects. The case presented here illustrates that the induced membrane technique described by Masquelet is a valuable option in treating this complication.
Promotional Effect of Fe Impurities in Graphene Precursors on the Activity of MnOX/Graphene Electrocatalysts for the Oxygen Evolution and Oxygen Reduction Reactions
Authors: Morales Dulce M. , Masa Justus , Andronescu Corina , Schuhmann Wolfgang 
Published: July 2017

AbstractBifunctional oxygen electrocatalysts were fabricated following a three‐step synthesis method, which consisted of i) liquid‐phase exfoliation of graphite in the presence of nitrogen‐containing manganese macrocyclic complexes, using DMF as the dispersion medium under formation of few‐layer graphene sheets. Subsequently, ii) solvent removal by vacuum filtration and drying, and iii) pyrolysis of the resulting composites under an inert gas atmosphere with subsequent mild calcination yielded manganese oxides embedded within a graphitic carbon matrix (MnOX/G). We further demonstrate that traces of Fe impurities in the used graphite result in enhanced electrocatalytic activity of the MnOX/G towards both the oxygen reduction and the oxygen evolution reactions, owing to synergistic interaction of the iron impurities with the species formed upon thermal decomposition of Mn macrocyclic complexes.
Ferroelectric Fractional‐Order Capacitors
Authors: Agambayev Agamyrat , Patole Shashikant P. , Farhat Mohamed , Elwakil Ahmed , Bagci Hakan , Salama Khaled N. 
Published: July 2017

AbstractPoly(vinylidene fluoride)‐based polymers and their blends are used to fabricate electrostatic fractional‐order capacitors. This simple but effective method allows us to precisely tune the constant phase angle of the resulting fractional‐order capacitor by changing the blend composition. Additionally, we have derived an empirical relationship between the ratio of the blend constituents and the constant phase angle to facilitate the design of a fractional‐order capacitor with a desired constant phase angle. The structural composition of the fabricated blends is investigated by using Fourier transform infrared spectroscopy and X‐ray diffraction techniques.
Regulated Drug Release Abilities of Calcium Carbonate–Gelatin Hybrid Nanocarriers Fabricated via a Self‐Organizational Process
Authors: Murai Kazuki , Kurumisawa Kazuya , Nomura Yoshihiro , Matsumoto Mutsuyoshi 
Published: July 2017

AbstractIn this study, we investigated the drug‐releasing behavior of a calcium carbonate (CaCO3)–gelatin hybrid nanocarrier, fabricated through a single process using biomimetic mineralization. The organic scaffold (gelatin) of the fabricated nanocarrier is responsible for its capacity to load anionic drugs and for controlling the morphology of the inorganic matrix (CaCO3). We studied the drug‐releasing properties of the nanocarrier by investigating the response of the CaCO3 matrix to acidic conditions. We found that under neutral conditions, drug release from the nanocarrier was inhibited, whereas under acidic conditions, the drug was efficiently released. Therefore, drug release from the nanocarrier is largely dependent on the surrounding pH.
Aquivion Perfluorosulfonic Superacid as an Efficient Pickering Interfacial Catalyst for the Hydrolysis of Triglycerides
Authors: Shi Hui , Fan Zhaoyu , Hong Bing , Pera‐Titus Marc 
Published: July 2017

AbstractRational design of the surface properties of heterogeneous catalysts can boost the interfacial activity in biphasic reactions through the generation of Pickering emulsions. This concept, termed Pickering interfacial catalysis (PIC), has shown promising credentials in acid‐catalyzed transesterification, ester hydrolysis, acetalization, etherification, and alkylation reactions. PIC has now been applied to the efficient, solvent‐free hydrolysis of the triglyceride glyceryl trilaurate to lauric acid, catalyzed by Aquivion perfluorosulfonic superacid at mild conditions (100 °C and ambient pressure).
Towards Extending Solar Cell Lifetimes: Addition of a Fluorous Cation to Triple Cation‐Based Perovskite Films
Authors: Salado Manuel , Fernández M. Asunción , Holgado Juan P. , Kazim Samrana , Nazeeruddin Mohammad Khaja , Dyson Paul J. , Ahmad Shahzada 
Published: July 2017

AbstractOrganohalide perovskites have emerged as highly promising replacements for thin‐film solar cells. However, their poor stability under ambient conditions remains problematic, hindering commercial exploitation. The addition of a fluorous‐functionalized imidazolium cation during the preparation of a highly stable cesium‐based mixed perovskite material Cs0.05(MA0.15FA0.85)0.95Pb(I0.85Br0.15)3 (MA=methylammonium; FA=formamidinium) has been shown to influence its stability. The resulting materials, which vary according to the amount of the fluorous‐functionalized imidazolium cation present during fabrication, display a prolonged tolerance to atmospheric humidity (>100 days) along with power conversion efficiencies exceeding 16 %. This work provides a general route that can be implemented in a variety of perovskites and highlights a promising way to increase perovskite solar cell stability.
Carbon Dioxide Capture by Aqueous Ionic Liquid Solutions
Authors: Simon Nathalia M. , Zanatta Marcileia , dos Santos Francisco P. , Corvo Marta C. , Cabrita Eurico J. , Dupont Jairton 
Published: July 2017

AbstractConfined water in aqueous solutions of imidazolium‐based ionic liquids (ILs) associated with acetate and imidazolate anions react reversibly with CO2 to yield bicarbonate. Three types of CO2 sorption in these “IL aqueous solutions” were observed: physical, CO2‐imidazolium adduct generation, and bicarbonate formation (up to 1.9 molbicarbonate mol−1 of IL), resulting in a 10:1 (molar ratio) total absorption of CO2 relative to imidazolate anions in the presence of water 1:1000 (IL/water). These sorption values are higher than the classical alkanol amines or even alkaline aqueous solutions under similar experimental conditions.
Development and validation of an optical biosensor for rapid monitoring of adalimumab in serum of patients with Crohn's disease
Authors: Bian Sumin , Lu Jiadi , Delport Filip , Vermeire Séverine , Spasic Dragana , Lammertyn Jeroen , Gils Ann 
Published: July 2017

AbstractTherapeutic drug monitoring of adalimumab is recommended to improve therapeutic outcome in patients with Crohn's disease. Performing an ELISA requires a rather long time‐to‐result and the necessity of collecting multiple samples to decrease the cost per adalimumab determination. In this study, we aim to develop and validate a rapid assay suitable for measuring a single adalimumab serum sample using a fiber‐optic surface plasmon resonance (FO‐SPR) based sensor. Therefore, we have immobilized MA‐ADM28B8 as capture antibody on an FO‐probe and conjugated MA‐ADM40D8 as detecting antibody to gold nanoparticles. A dose–response curve ranging from 2.5 to 40 ng/mL adalimumab was obtained in 1/400 diluted serum. Serum samples of patients with adalimumab concentrations between 1 and 16 μg/mL were measured whereas the negative control, a sample spiked with infliximab at a concentration of 16 μg/mL, showed no significant signal. Using a pre‐functionalized FO‐probe, the technology requires less than 45 minutes for measuring a single sample. Comparison of measurements between the biosensor and the ELISA revealed an excellent agreement with a Pearson r coefficient of 0.99 and an intra‐class coefficient of 0.99. The reduced assay time and the possibility of measuring a single sample are major advantages compared to the ELISA. The developed and validated optical adalimumab biosensor could be a valuable point‐of‐care diagnostic tool for adalimumab quantification in patients with Crohn's disease.
Reproductive consequences of habitat fragmentation for a declining resident bird of the longleaf pine ecosystem
Authors: Winiarski Jason M. , Moorman Christopher E. , Carpenter John P. , Hess George R. 
Published: July 2017

AbstractHabitat loss and fragmentation are major threats to bird population persistence. Yet, our understanding of the demographic factors behind the adverse effects of fragmentation remains limited for many species. We studied the breeding demographics of the Bachman's Sparrow (Peucaea aestivalis), a species of conservation concern that is associated with highly imperiled longleaf pine ecosystems in the southeastern United States. We quantified the effects of local‐ and landscape‐scale factors on different components of reproductive success (i.e., pairing success and probability of fledging offspring) for 96 male sparrows at eight sites in southeastern North Carolina. Pairing success of monitored sparrows was 69%, and 77% of paired males fledged ≥1 offspring. Habitat amount in the surrounding landscape, rather than local habitat quality, was the most influential predictor of pairing success for male Bachman's Sparrows. In contrast, we documented no predictors of successfully fledging offspring for paired males. We infer that reduced pairing success is limiting reproduction in isolated landscapes and may be a contributing factor for the low occupancy and declines of Bachman's Sparrow in our study region. Overall, our results suggest that managers can promote breeding opportunities for Bachman's Sparrows by prioritizing resources to patches near large, preexisting longleaf pine forest to ensure ≥20% habitat within the surrounding landscape.
Marginally Hydrogenated Triphasic Titania Nanotubes for Effective Visible‐Light Photocatalytic Hydrogen Generation
Authors: Preethi Laguduva K. , Mathews Tom , Walczak Lukasz , Gopinath Chinnakonda S. 
Published: July 2017

AbstractWe report the first demonstration of hydrogen‐annealed triphase TiO2 nanotubes (anatase–rutile–brookite) (T‐ARB) as a visible‐light‐active photocatalyst for water splitting with high quantum efficiency. As‐synthesized T‐ARB was annealed under hydrogen atmosphere at 250 and 450 °C for 2 h. We found that the tubular structures were retained in the hydrogenated TiO2 samples. It was observed that the concentrations of Ti3+ and the oxygen vacancies and their distribution significantly increased with respect to the hydrogen annealing temperature. Such changes in defects were found to be critical in enhancing the photocatalytic activity of the hydrogen‐annealed triphase TiO2 nanotubes. The triphase TiO2 nanotubes hydrogen annealed at 450 °C were 16 times more efficient than pristine TiO2. Such an increase in the photocatalytic activity was explained by a triphase band diagram with defect states below the conduction band of each phase, which facilitated visible‐light activity and easy transfer of charge carriers from one phase to another. Our study showed that the well‐designed multiphase construction with oxygen vacancies enhanced the photocatalytic activity tremendously owing to the presence of a higher number of phase junctions.
Hydrogen Generation on Metal/Mesoporous Oxides: The Effects of Hierarchical Structure, Doping, and Co‐catalysts
Authors: Moon Song Yi , Gwag Eun Heui , Park Jeong Young 
Published: July 2017

AbstractPhotocatalytic water splitting for the generation of hydrogen fuel under solar‐light illumination is a sustainable and renewable energy technology to solve environmental issues. Numerous attempts have been made to develop a stable and efficient visible‐light‐driven photocatalyst for hydrogen evolution. Several factors (e.g., morphology, surface area, crystallinity, and band structure of the catalyst and charge transfer at the oxide‐metal interface) have been shown to affect the solar‐to‐hydrogen energy‐conversion efficiency. Recently, various modification strategies for metal‐oxide photocatalysts, including cation/anion doping for visible‐light harvesting, have been suggested. Furthermore, a series of new engineering methods that introduce co‐catalysts, dye sensitizers, and quantum dots appear to improve the photocatalytic activity for hydrogen generation. In this article, we give an overview of the molecular‐scale factors that influence the efficiency of hydrogen evolution and outline recent progress of commonly used engineering strategies that search for higher efficiency in the generation of hydrogen. Specifically, nanostructured photocatalysts, including hierarchical mesoporous structures, were investigated for the production of hydrogen. Finally, great achievements in the emerging field of surface‐plasmon‐induced hot‐electron‐driven hydrogen generation are discussed.
Structured identification of response options to address environmental health risks at the Agbogbloshie electronic waste site
Authors: Cazabon Danielle , Fobil Julius N , Essegbey George , Basu Niladri 
Published: July 2017

Abstract

Electronic waste (e-waste) is a growing problem across low- and middle-income countries. Agbogbloshie (Accra, Ghana) is among the world's largest and most notorious e-waste sites, with an increasing number of studies documenting a range of environmental health risks. The present study aimed to provide national, regional, and international stakeholders with a summary of expert opinion on the most pressing problems arising from e-waste activities at Agbogbloshie, as well as suggested solutions to address these problems. Structured interviews were performed between April and September 2015 that used a Logical Framework Approach as a scoping exercise to gauge problems and benefits of e-waste recycling, and the Delphi methodology to identify response options. Stakeholders (n = 19) from 15 institutions were interviewed with 2 rounds of a Delphi Poll: open-ended interviews followed by an electronic questionnaire in which experts ranked various proposed response options based on health, environmental, social, and economic benefit and feasibility. The goal was to prioritize potential interventions that would address identified problems at Agbogbloshie. Experts identified the most beneficial and feasible options in decreasing rank order as follows and prefaced by the statement “it is recommended that”: 1) there be further research on the health effects; 2) e-waste workers be given appropriate personal protective equipment; 3) the Ministry of the Environment, Science, Technology and Innovation re-visit Ghana's Hazardous Waste Bill; 4) e-waste workers be involved in the planning process of interventions and are be kept informed of any results; and 5) there be increased education and sensitization on hazards related to e-waste for both workers and the general public. These solutions are discussed in relation to ongoing dialogue at the international level concerning e-waste recycling interventions, with strengths and weaknesses examined for the Ghanaian context. Integr Environ Assess Manag 2017;13:980–991. ©2017 SETAC

Key Points
This is one of the first studies to systematically identify options to address the environmental health concerns associated with e-waste, even though the activity is escalating worldwide. Key response options included a need for more research, the use of personal protective equipment, passing national laws, involvement of the workers themselves in the planning of interventions, and education. The outcome of the study has direct and immediate relevance to a number of active discussions at the national, regional, and international levels concerning the assessment and management of e-waste.
In vivo comparison of jellyfish and bovine collagen sponges as prototype medical devices
Authors: Widdowson Jonathan P. , Picton Alex J. , Vince Valerie , Wright Chris J. , Mearns‐Spragg Andrew 
Published: July 2017

AbstractJellyfish have emerged as a source of next generation collagen that is an attractive alternative to existing sources, such as bovine and porcine, due to a plentiful supply and providing a safer source through lack of bovine spongiform encephalopathy (BSE) transmission risk and potential viral vectors, both of which could be transmitted to humans. Here we compare collagen implantable sponges derived for the first time from the Rhizostoma pulmo jellyfish. A further novelty for the research was that there was a comparison for sponges that were either uncrosslinked or crosslinked using 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide hydrochloride (EDC), and an assessment on how this affected resorption, as well as their biocompatibility compared to bovine type I collagen sponges. The scaffolds were prepared and examined using sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS PAGE) and scanning electron microscopy (SEM). The samples were implanted in adult male Wistar rats for in vivo experimentation. Both crosslinked and uncrosslinked jellyfish collagen sponges showed a significant reduction in histopathology scores over the course of the study, whereas the bovine collagen sponge scores were not significantly reduced. Both jellyfish collagen sponges and the bovine sponge were tolerated well by the hosts, and a recovery was visible in all samples, suggesting that R. pulmo jellyfish‐derived collagen could offer compelling biocompatibility with wound healing applications. We also demonstrate that noncrosslinked samples could be safer with better resorption times than crosslinked samples. © 2017 The Authors Journal of Biomedical Materials Research Part B: Applied Biomaterials Published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1524–1533, 2018.
A Review of Moxifloxacin for the Treatment of Drug‐Susceptible Tuberculosis
Authors: Naidoo Anushka , Naidoo Kogieleum , McIlleron Helen , Essack Sabiha , Padayatchi Nesri 
Published: July 2017

AbstractMoxifloxacin, an 8‐methoxy quinolone, is an important drug in the treatment of multidrug‐resistant tuberculosis and is being investigated in novel drug regimens with pretomanid, bedaquiline, and pyrazinamide, or rifapentine, for the treatment of drug‐susceptible tuberculosis. Early results of these studies are promising. Although current evidence does not support the use of moxifloxacin in treatment‐shortening regimens for drug‐susceptible tuberculosis, it may be recommended in patients unable to tolerate standard first‐line drug regimens or for isoniazid monoresistance. Evidence suggests that the standard 400‐mg dose of moxifloxacin used in the treatment of tuberculosis may be suboptimal in some patients, leading to worse tuberculosis treatment outcomes and emergence of drug resistance. Furthermore, a drug interaction with the rifamycins results in up to 31% reduced plasma concentrations of moxifloxacin when these are combined for treatment of drug‐susceptible tuberculosis, although the clinical relevance of this interaction is unclear. Moxifloxacin exhibits extensive interindividual pharmacokinetic variability. Higher doses of moxifloxacin may be needed to achieve drug exposures required for improved clinical outcomes. Further study is, however, needed to determine the safety of proposed higher doses and clinically validated targets for drug exposure to moxifloxacin associated with improved tuberculosis treatment outcomes. We discuss in this review the evidence for the use of moxifloxacin in drug‐susceptible tuberculosis and explore the role of moxifloxacin pharmacokinetics, pharmacodynamics, and drug interactions with rifamycins, on tuberculosis treatment outcomes when used in first‐line tuberculosis drug regimens.