bluuebunny/crossref_metadata_2025_split huggingface dataset:
FABP1 induces lipogenesis by regulating the processing of SREBP1 in hepatocytes of large yellow croaker (Larimichthys crocea)
Authors: Chen Fan , Hao Tingting , Chen Qiang , Sun Yuning , Shen Yanan , Zhao Zengqi , Du Jianlong , Li Yueru , Mai Kangsen , Ai Qinghui 
Published: September 2024

AbstractFatty acid‐binding protein 1 (FABP1) plays an important role in regulating fatty acid metabolism in liver, which is a potential therapeutic target for diseases such as non‐alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms are not well defined. Using complementary experimental models, we discovered FABP1 induction in hepatocytes as a primary mediator of lipogenesis when exposed to fatty acids, especially saturated fatty acids (SFAs). In the feeding trial, palm oil led to excess lipid accumulation in the liver of large yellow croaker (Larimichthys crocea), accompanied by significant induction of FABP1. In cultured cells, palmitic acid (PA), a kind of SFA, triggered the fabp1 expression and increased triglyceride (TG) contents. Knockdown of FABP1 dampened PA‐induced TG accumulation through mitigated lipogenesis. The overexpression of FABP1 showed the opposite result. Furthermore, the inactivation of FABP1 led to induction in insulin‐induced gene 1 (INSIG1) expression, which attenuated the processing of sterol regulatory element‐binding protein 1 (SREBP1) by down‐regulating the nuclear‐localized SREBP1. These results revealed a previously unrecognized function of FABP1 in response to PA, providing additional evidence for targeting FABP1 in the treatment of NAFLD caused by SFA.
IRF5 Variants Are Risk Factors for Systemic Lupus Erythematosus in Two Mexican Populations
Authors: López-Briceño Isaac A. , Ramírez-Bello Julian , Montúfar-Robles Isela , Barbosa-Cobos Rosa Elda , Ángulo-Ramírez Angélica V. , Valencia-Pacheco Guillermo 
Published: September 2024

Introduction
Interferon regulatory factor 5 (IRF5) is one of the pivotal genes implicated in systemic lupus erythematosus (SLE) among diverse ethnic groups, including Europeans, Asians, Hispanics, and Africans. Notably, its significance appears particularly pronounced among Hispanic populations. Previous studies have identified several single-nucleotide variants within IRF5, such as rs2004640G/T, rs2070197T/C, and rs10954213G/A, as associated with susceptibility to SLE among patients from Mexico City. However, the population of Yucatan, located in the Southeast of Mexico and characterized by a greater Amerindian genetic component, remains largely unexplored in this regard.

Objectives
Our study aimed to replicate the observed association between IRF5 variants and susceptibility to SLE among patients from Central Mexico and Yucatan. Furthermore, we investigated the impact of IRF5 rs59110799G/T, a variant that has not been previously studied in SLE individuals.

Method
Our study included 204 SLE patients and 160 controls from Central Mexico, as well as 184 SLE patients and 184 controls from Yucatan. All participants were females 18 years and older. We employed a TaqMan assay to detect the presence of the following single-nucleotide variants: rs2004640G/T, rs2070197T/C, rs10954213G/A, and rs59110799G/T. Furthermore, we utilized 2 distinct web tools and databases to predict the potential functional implications of IRF5 variants.

Results
In SLE patients from Central Mexico, several IRF5 alleles showed significant associations with the disease following adjustment by the Bonferroni test: the rs2070197C allele (odds ratio [OR], 2.08), the rs10954213A allele (OR, 1.59), and the rs59110799G allele (OR, 1.71). Conversely, among patients from Yucatan, the following alleles showed associations: rs2004640T (OR, 1.51), rs2070197C (OR, 1.62), rs10954213A (OR, 1.67), and rs59110799G (OR, 1.44).

Conclusion
Our findings highlight genetic variations between Mexican populations and emphasize the role of IRF5 as a risk factor in SLE patients from both Central Mexico and Yucatan.
Wind tunnel investigation of hemispherical forebody interaction on the drag coefficient of a D-shaped model
Authors: V. Suresh , Balusamy Kathiravan , Chidambaram Senthilkumar 
Published: September 2024

Purpose
An experimental investigation of hemispherical forebody interaction effects on the drag coefficient of a D-shaped model is carried out for three-dimensional flow in the subcritical range of Reynolds number 1 × 105 ≤ Re ≤ 1.8 × 105. To study the interaction effect, hemispherical shapes of various sizes are attached to the upriver of the D-shaped bluff body model. The diameter of the hemisphere (b1) varied from 0.25 to 0.75 times the diameter of the D-shaped model (b2) and its gap from the D-shaped model (g/b2) ranged from 0.25 to 1.75 b2.

Design/methodology/approach
The experiments were carried out in a low-speed open-circuit closed jet wind tunnel with test section dimensions of 1.2 × 0.9 × 1.8 m (W × H × L) capable of generating maximum velocity up to 45 m/s. The wind tunnel is equipped with a driving unit which has a 175-hp motor with three propellers controlled by a 160-kW inverter drive. Drag force is measured with an internal six-component balance with the help of the Spider 3013 E-pro data acquisition system.

Findings
The wind tunnel results show that the hemispherical forebody has a diameter ratio of 0.75 with a gap ratio of 0.25, resulting in a maximum drag reduction of 67%.

Research limitations/implications
The turbulence intensity of the wind tunnel is about 5.6% at a velocity of 18 m/s. The uncertainty in the velocity and the drag coefficient measurement are about ±1.5 and ±2.83 %, respectively. The maximum error in the geometric model is about ±1.33 %.

ractical implications
The results from the research work are helpful in choosing the optimum spacing of road vehicles, especially truck–trailer and launch vehicle applications.

Social implications
Drag reduction of road vehicle resulting less fuel consumption as well as less pollution to the environment. For instance, tractor trailer experiencing approximately 45% of aerodynamics drag is due to front part of the vehicle. The other contributors are 30% due to trailer base and 25% is due to under body flow. Nearly 65% of energy was spent to overcome the aerodynamic drag, when the vehicle is traveling at the average of 70 kmph (Seifert 2008 and Doyle 2008).

Originality/value
The benefits of placing the forebody in front of the main body will have a strong influence on reducing fuel consumption.
Responsibilization as a return to collectivity? Legitimating the responsibilization of preparedness: the case of the Swedish Civil Contingencies Agency (MSB)
Authors: Ågren Malin 
Published: September 2024

PurposeThis study investigates how communication is used by a Swedish public authority to legitimate the responsibilization of preparedness, i.e. how the state encourages individual citizens to take more responsibility for their security.Design/methodology/approachA multimodal discursive approach drawing on multimodal narrative analysis of video clips and multimodal critical discourse analysis (MCDA) is used to examine how the responsibilization of preparedness is legitimated in video material published on Swedish Civil Contingencies Agency's (MSB’s) YouTube channel.FindingsThe study finds that the responsibilization of preparedness is legitimated through an ongoing but evolving normalization of threat. The findings also show how responsibilization is legitimated in moralizing terms of individual contribution to society, which may indicate a return from neo-liberal values to more traditional Swedish collectivist values.Originality/valueThe study shows how communication around preparedness and responsibilization is discursively constructed and legitimated through multimodal features, while previous research has mainly focused on verbal or written communication.
Evaluating Uganda’s preferential market access; trade intensity, comparative advantage and the potential for trade
Authors: Ecel Aaron , Ahimbisibwe Godwin Mwesigye , Nuwagaba Dennis , Nankya Mariah Nakintu , Nahurira Shareen 
Published: September 2024

Purpose
Preferential market access is a pillar of the enabling clause in international trade, and as such has received scholarly attention in the recent past. This study aims to empirically examine intensity and utilisation of Uganda’s preferential market access.

Design/methodology/approach
Secondary data at the six-digit level of the harmonised system was sourced from the International Trade Centre’s and UN COMTRADE’s Trade Map database on trade flows to compute; trade intensity indices, Balsa’s revealed comparative advantage (RCA) indices and the existing potential trade. The time period was 2013–2022.

Findings
It is evident that Uganda is not taking full advantage of its preferential market access. The findings of the trade intensity analysis revealed that the strength of trade relations between Uganda and its preferential markets has been consistently weak in the period 2013–2022, while the intensity of trade relations with its FTA partners has been strong. The RCA results revealed that all Uganda’s agricultural exports to its preferential markets have a comparative advantage, with exports of roses reporting an exceptionally high RCA relative to other agricultural exports. The RCA results also show that the comparative advantage of Uganda’s coffee exports recovered after a significant fall in the period 2014–2022. The analysis of the existing potential for trade reveals a disproportionally low market share held by Uganda across all product lines, notably, only 2.3% of the US$29bn coffee imports in its preferential markets.

Research limitations/implications
One limitation of this study is that it primarily relied on quantitative data from the International Trade Centre and thus lacks an exhaustive understanding of the circumstances at the export firm level. Qualitative data, such as interviews with exporters and policymakers, could provide deeper insights into the specific challenges and opportunities faced by Ugandan businesses in these markets.

Practical implications
This paper highlights the need for additional trade facilitation measures to address preferential market access bottlenecks such as stringent rules of origin and call for an aggressive government intervention in enhancing the export readiness of SMEs in Uganda. In addition, the paper is informative to Uganda’s exporters regarding the existing and potential increase in their exports to international markets.

Originality/value
The strength of Uganda’s trade relations with its preferential markets is empirically examined in this paper and provides useful insights for enhancing utilisation of preferential market access by beneficiary countries.
Facility network design by using k-mean and elbow method: a case of Indian handloom industry
Authors: Naik M.K.P. , Bhardwaj Prabhas 
Published: September 2024

Purpose
This study aims to design a facility network for the weavers to do direct business in the Indian handloom industry by using tourists as potential customers.

Design/methodology/approach
Data from 4,001 weavers of the handloom industry and 82 tourist locations of Varanasi city were collected. This data was analysed using the k-mean and elbow methods to determine the locations and the optimal number of collection centres, selling stores and warehouses to provide opportunities for the weavers to do direct business.

Findings
The study's findings showed that a greater opportunity could be provided with four optimal collection centres and selling stores, along with two warehouses in the handloom industry of Varanasi city. These results provide valuable guidance for policymakers to plan the Varanasi handloom network of facilities efficiently and effectively to improve the conditions of weavers.

Originality/value
Determining the optimal locations is crucial for designing a facility network. The proposed network will aid the government and policymakers in comprehending and pinpointing potential sites to establish new facilities in the handloom industry in Varanasi, a city with tourism potential.
Role of social media and library marketing in Indian universities
Authors: Kumar Shiv , Chohda Nirupma , Gupta Richa 
Published: September 2024

Purpose
Social media marketing (SMM) denotes attaining website traffic or attention through social media platforms. The paper aims to focus on examining the viewpoint of library professionals from different universities along with the user respondents from different disciplines and universities on the role of social media tools to market university libraries.

Design/methodology/approach
It is a survey-based study that used the questionnaire as its chief data collection instrument designed to be administered to library professionals (n = 100) and users (n = 1,189) from eight universities. The study also adopted the general observation and interview methods to supplement the data. The data was analyzed using SPSS software, and Chi-square test and ANOVA were applied to ascertain the significant variations in viewpoints of the library professionals and the users.

Findings
The research study showed that library professionals (from different universities) and users (from different disciplines and universities) felt that social media could be an appropriate marketing tool for libraries in the future. Observations during data collection highlighted a lack of confidence and unwillingness among library professionals to implement any changes in the present time.

Practical implications
The present study provides some significant insights for improving the current situation of the libraries under study in terms of increasing awareness among the students and adopt social media tools for marketing of library facilities and services in future. It is important to note that a few issues that came into light during data collection were a marked lack of willingness and prevalence of less confidence among the library professionals to execute or implement the social media tools to market library resources and services among the users.

Originality/value
SMM programs focus on creating content that attracts attention and encourages readers to use it. This study attempts to fill the gap in of marketing in libraries through social media. The paper offers insights into the use of marketing tools for promoting library resources and services as per the needs of library users. The research work differs from other studies undertaken on library marketing related to social media as it has included both library professionals and users together to obtain a better picture in this regard.
Exploring the antecedents and consequences of brand addiction among Iranian consumers
Authors: Vakili Marziyeh , Salehzadeh Reza , Esmailian Hassan 
Published: September 2024

Purpose
Because brand addiction is one of the most intense forms of consumer–brand relationships, this type of behavior has recently attracted the attention of researchers in the field of consumer behavior management. The purpose of this paper is to investigate the antecedents and consequences of brand addiction among Iranian consumers.

Design/methodology/approach
This research used a cross-sectional study based on a questionnaire to collect data from a sample of 401 people in Iran. Structural equation modeling was used to test the hypotheses.

Findings
This study found that brand love and brand involvement significantly influence brand addiction. Brand addiction was also positively associated with contingent self-esteem (CSE), compulsive shopping and resilience to negative information. Additionally, the results revealed a positive and significant effect of brand involvement on brand love and a similar positive and significant effect of CSE on compulsive shopping.

Originality/value
By examining the antecedents and consequences of brand addiction in an Islamic country, this research offers valuable insights that can enrich the literature on brand addiction in consumer behavior and brand management.
You want my loyalty? Treat me fairly! A study of Islamic banking customers in South Africa
Authors: Roberts-Lombard Mornay , Petzer Daniël Johannes 
Published: September 2024

Purpose
The purpose of this study is to investigate possible drivers of loyalty amongst Islamic banking customers in Gauteng, South Africa. We ponder the relationships of service fairness (a secondorder reflective construct) with perceived value, satisfaction, and loyalty.

Design/methodology/approach
Data were obtained from Islamic banking customers in South Africa using interview-administered questionnaires. A total of 350 responses were perceived as being suitable for data analysis. The measurement and structural models were measured through structural equation modelling.

Findings
Service fairness and perceived value were found to be important drivers of loyalty within this context.

Research limitations/implications
This study demonstrates that service fairness and perceived value are precursors to the future loyalty intentions of Islamic banking customers. As such, they should be nurtured as key elements of the relationship building process.

Practical implications
The study guides South African Islamic banks and South African banks with Islamic windows to better understand how service fairness (interactional, procedural and distributive) fosters satisfaction, perceived value and loyalty (attitudinal and behavioural).

Originality/value
Enhancing comprehension of the relationship between service fairness and customer loyalty, with satisfaction and perceived value playing intermediary roles, represents an unexplored avenue in academic research within the context of Islamic banking in an emerging African market.
A call to adopt pedagogies of optimism in times of armed conflicts: theoretical and practical insights
Authors: Oplatka Izhar 
Published: September 2024

PurposeThe paper argues for the introduction of pedagogies of optimism (and implicitly of hope) in schools as a response to the danger of pessimism, skepticism and helplessness characterizing periods of armed conflicts.Design/methodology/approachA conceptual analysis.FindingsFollowing an analysis of armed conflicts and their impact on educational systems, the critical contribution of pedagogies of optimism is illuminated. Teachers are encouraged to follow major phases in this kind of pedagogy, such as discovery, acceptance of the situation, imagination and critical thinking.Originality/valuePractical suggestions are provided at the end of the paper.
Artificial intelligence (AI) tools for academic research
Authors: Oyelude Adetoun A. 
Published: September 2024

Purpose
The purpose of the paper is to explore the rapidly evolving landscape of artificial intelligence (AI) tools in academic research, highlighting their potential to transform various stages of the research process. AI tools are transforming academic research, offering numerous benefits and challenges.

Design/methodology/approach
Academic research is undergoing a significant transformation with the emergence of (AI) tools. These tools have the potential to revolutionize various aspects of research, from literature review to writing and proofreading. An overview of AI applications in literature review, data analysis, writing and proofreading, discussing their benefits and limitations is given. A comprehensive review of existing literature on AI applications in academic research was conducted, focusing on tools and platforms used in various stages of the research process. AI was used in some of the searches for AI applications in use.

Findings
The analysis reveals that AI tools can enhance research efficiency, accuracy and quality, but also raise important ethical and methodological considerations. AI tools have the potential to significantly enhance academic research, but their adoption requires careful consideration of methodological and ethical implications. The integration of AI tools also raises questions about authorship, accountability and the role of human researchers. The authors conclude by outlining future directions for AI integration in academic research and emphasizing the need for responsible adoption.

Originality/value
As AI continues to evolve, it is essential for researchers, institutions and policymakers to address the ethical and methodological implications of AI adoption, ensuring responsible integration and harnessing the full potential of AI tools to advance academic research. This is the contribution of the paper to knowledge.
Implementing a mental health app intervention in a university setting: multi-methods evaluation study
Authors: Liverpool Shaun , Fletcher Ken , Chopra Tahira Kaur , Jay David , Walters Faye , Kaye Linda K. 
Published: September 2024

Purpose
The number of university students seeking mental health support is rapidly increasing. To provide additional psychological support to students accessing well-being services, this study aimed to pilot a mental health Web application (app) called Orpheus®.

Design/methodology/approach
Guided by student consultations, a multi-methods approach was adopted, including an examination of in-app data, chart reviews of routinely collected student information and interviews with mental health practitioners. Usage data were analysed descriptively. Changes in mental health outcomes were examined using means, standard deviations and reliable change indices for anxiety and depression scores. Inductive and deductive thematic analysis was conducted on qualitative data from staff interviews and student feedback.

Findings
A total of 26 students registered an account with 39 completed app visits. On 37 of the 39 (94.9%) occasions, students reported reductions in the intensity of unwanted negative emotions. Statistically significant reductions in the average pooled anxiety and depression scores were observed. Of the 15 students who completed pre- and post-routine outcome measures, between 20% and 60% showed reliable and meaningful symptom improvements. Students reported that the app was helpful and easy to set up and use, with no adverse events. Practitioners highlighted barriers and facilitators related to the technology features, situational contexts and individual differences.

Originality/value
Integrating Orpheus in real-world settings resulted in promising implementation processes, potential for future uptake and positive outcomes. However, ongoing research, staff training and app testing are needed to further improve the implementation processes for digital mental health interventions.