bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regeneration-Induced Variances of Aeroelastic Properties of Turbine Blades
Authors: Stania Lennart , Seume Joerg R. 
Published: September 2024

AbstractRegeneration and wear result in geometric deviations between design intent and reality of turbine blades. These deviations influence the aerodynamic flow field and the aeroelastic behaviour of downstream blades. As an example for the effect of such deviations between modules on blade vibration amplitudes, an experiment is set up to determine the influence of cold streaks, which can occur due to widening of cooling air holes. The vibration amplitude for an off-design point is increased by 20% and for the design point as well. We conclude that the forced response caused by cooling air from the turbine blades must be considered during the design process and for life predictions, especially for higher relative cooling air mass flows. Furthermore, different geometric deviations may occur simultaneously, which can magnify the vibration amplitude even further. A probabilistic process presented here investigates these combined effects. It is shown that a maximum amplitude exists within the given geometric boundaries. Using this information, new safety margins can be set for geometric deviations in the repair or manufacturing process.
Local Governments and Public Administration
Authors: Ohsugi Satoru 
Published: September 2024

AbstractA quarter of a century after decentralization reforms began, local governments in Japan find themselves standing at a crossroads.The role of local autonomous bodies in the government sector is exceedingly huge. On the other hand, significant financial disparities continue to exist among local governments. The level of administrative services has been left to the discretion of the regions due to decentralization reforms. When we consider the full-scale arrival of a society marked by a declining birthrate, aging population, and depopulation, it is uncertain as to whether the current system is sustainable.In this chapter, the author will focus on the organizational structure and operations of local governments and go over their basic structure and operational reality. It can be said that the ability of local governments to proactively and flexibly deal with the various challenges faced by Japan rests on this point. Going forward, local governments are expected to be the driving force behind open innovation at the will of the local community as they aim to cultivate a society rich in diversity in accordance with actual local conditions while coordinating with various actors.
Multimorbidität als Prädiktor für eine stationäre Aufnahme in der klinischen Notfall- und Akutmedizin
Authors: Grüneberg E. , Fliedner R. , Beißbarth T. , von Arnim C. A. F. , Blaschke S. 
Published: September 2024

Zusammenfassung
Hintergrund
Infolge der demografischen Entwicklung ist ein deutlicher Anstieg von multimorbiden Notfallpatient*innen in der klinischen Notfall- und Akutmedizin in Deutschland zu verzeichnen. Zur Definition operationalisierbarer Kriterien für die Notwendigkeit der stationären Aufnahmeindikation in diesem Patientenkollektiv wurde eine hierarchische Clusteranalyse durchgeführt.

Methodik
In einer retrospektiven, monozentrischen Studie wurden Daten von n = 35.249 Notfällen (01/2016–05/2018) analysiert. Multimorbidität (MM) wurde bei Vorliegen von mehr als 5 im Behandlungsverlauf resultierenden ICD-10-GM-Diagnosen definiert. Es erfolgte eine hierarchische Clusteranalyse der zuvor in 112 Subcluster zusammengefassten Diagnosen zur Ermittlung spezifischer Cluster stationärer und ambulanter Fälle.

Ergebnisse
Stationäre Aufnahmen erfolgten bei 81,2 % aller Notfälle (n = 28.633). Die Kriterien der MM wurden bei 54,7 % der stationären (n = 15.652) und 0,97 % der ambulanten Fälle (n = 64) erfüllt. Der Altersunterschied zwischen letzteren war hochsignifikant (68,7/60,8 Jahre; p < 0,001).
Durch hierarchische Clusteranalyse wurden für stationär aufgenommene, multimorbide Patient*innen (MP) 13 Cluster mit unterschiedlichen Diagnosen und für ambulante MP 7 Cluster mit vorrangig hämatologischen Malignomen identifiziert. Die Notaufnahmeverweildauer (VWD) stationärer MP war mehr als doppelt so lang (max. 8,3 h) wie die ambulanter MP (max. 3,2 h).

Schlussfolgerungen
Es wurden für MM typische Diagnosekombinationen in Form von Clustern identifiziert. Im Vergleich zu monodimensionalen oder kombinierten Diagnosen resultiert durch die statistisch erhobene Clusterbildung eine wesentlich genauere Prognose für die Disposition in der klinischen Notfallversorgung als auch für die leistungsrechtliche Prozesszuordnung.
Allies not enemies—creating a more empathetic and uplifting patient experience through technology and art
Authors: Tagliaferri Luca , Fionda Bruno , Casà Calogero , Cornacchione Patrizia , Scalise Sara , Chiesa Silvia , Marconi Elisa , Dinapoli Loredana , Di Capua Beatrice , Chieffo Daniela Pia Rosaria , Marazzi Fabio , Frascino Vincenzo , Colloca Giuseppe Ferdinando , Valentini Vincenzo , Miccichè Francesco , Gambacorta Maria Antonietta 
Published: September 2024

Abstract

Objective
To understand whether art and technology (mainly conversational agents) may help oncology patients to experience a more humanized journey.

Methods
This narrative review encompasses a comprehensive examination of the existing literature in this field by a multicenter, multidisciplinary, and multiprofessional team aiming to analyze the current developments and potential future directions of using art and technology for patient engagement.

Results
We identified three major themes of patient engagement with art and three major themes of patient engagement with technologies. Two real-case scenarios are reported from our experience to practically envision how findings from the literature can be implemented in different contexts.

Conclusion
Art therapy and technologies can be ancillary supports for healthcare professionals but are not substitutive of their expertise and responsibilities. Such tools may help to convey a more empathetic and uplifting patient journey if properly integrated within clinical practice, whereby the humanistic touch of medicine remains pivotal.
Tensile properties of 3D-printed PLA prismatic cellular structures: an experimental investigation
Authors: Khan Hashim , Siddiqi Muftooh ur Rehman , Saher Saim , Muhammad Riaz , Rehan Muhammad Saad 
Published: September 2024

AbstractAdvancements in additive manufacturing have significantly increased the use of cellular structures in product development, especially in the automotive, aerospace, and biomedical industries, due to their enhanced strength-to-weight ratio and energy-absorbing capabilities. This study investigates the tensile properties of 3D-printed PLA prismatic cellular structures, focusing on the effects of fillet radius, wall thickness, and cell size on tensile strength, Young’s modulus, and strength-to-weight ratio. Using a full factorial design and ANOVA, we examined the impact and interaction of each geometrical parameter. Our findings show that triangular cellular structures exhibit a higher stiffness of 1.36 GPa and tensile strength of 24.28 MPa, resulting in a notable 5.78 MPa/gram strength-to-weight ratio. Increasing cell count and wall thickness enhances both tensile strength and Young’s modulus, whereas adding fillet radii at corners reduces these properties. Fracture behaviors are influenced by geometrical design: shorter, thicker walls lead to progressive crack propagation, while longer, thinner walls tend to fail catastrophically. Fillet radius introduction shifts the fracture initiation point from the nodes. ANOVA results indicate that wall thickness and cell size significantly affect tensile strength and Young’s modulus, contributing 36.53% and 53.54%, respectively.
New evidence of late Neolithic and early Metal Period agriculture in Turku, southwest Finland
Authors: Lempiäinen-Avci Mia , Pukkila Jouko , Bläuer Auli , Pääkkönen Mirva , Asplund Henrik 
Published: September 2024

AbstractA re-evaluation of late Neolithic cereal grains, combined with new archaeobotanical data, add to the evidence of late Neolithic and early Metal Period farming in southwest Finland. Earlier indications of late Neolithic cereals at the Niuskala Kotirinne site in Turku are confirmed by new radiocarbon dating results. An early occurrence of Hordeum has also found at a second site nearby, Räntämäki Riihivainio. The finds are discussed in relation to early dates of cereal finds and other indications of farming, as well as general interpretations of the earliest cereal growing in Finland and the northern Baltic region.
Procedural safety of rotational atherectomy and modified balloon angioplasty: insights from a German national registry
Authors: Maier Alexander , Gissler Mark Colin , Jäckel Markus , Oettinger Vera , Bacmeister Lucas , Heidenreich Adrian , Rilinger Jonathan , Heger Lukas A. , Bojti István , Weber Christian , Wolf Dennis , Hilgendorf Ingo , Rahimi Faridun , Ferenc Miroslaw , Westermann Dirk , Kaier Klaus , von zur Mühlen Constantin 
Published: September 2024

Abstract
Background
Modified balloons (MB) and rotational atherectomy (RA) are recommended tools for treatment of coronary plaques with superficial calcium. Knowledge about in-hospital safety is limited.

Methods
Patients with coronary artery disease who underwent coronary angiography with RA or MB angioplasty in Germany were identified via ICD and OPS codes from 2017 to 2020. Acute coronary syndromes were excluded. Since patients were not randomized toward MB or RA, potential confounding factors were taken into account using the propensity score methods. Thereby, inverse probability weighting was applied.

Results
Ten thousand.ninety-twopatients underwent RA with an increasing trend from 1817 in 2017 toward 3166 in 2020. MBs were used in 22,378 patients also with an increasing trend from 4771 in 2017 toward 6078 in 2020.
Patients receiving RA were older (74.23 ± 8.68 vs. 71.86 ± 10.02, p < 0.001), had a higher Charlson Comorbidity Index (2.07 ± 1.75 vs. 1.99 ± 1.76, p = 0.001) and more frequently left main (17.96% vs. 12.91%, p < 0.001) or three vessel disease (66.25% vs. 58.10%, p < 0.001). Adjusted procedural risk of major adverse cardiac and cerebrovascular events (MACCE) was similar in both groups, while pericardial effusion (RR 2.69; 95% CI 1.88–3.86, p < 0.001), pericardial puncture/pericardiotomy/pericardial tamponade (RR 2.66; 95% CI 1.85–3.81, p < 0.001) and bleeding (RR 1.65; 95% CI 1.12–2.43, p < 0.011) occurred more frequently in patients receiving RA. Patients treated with RA at high volume centers were hospitalized shorter (p = 0.005) and had a lower rate of acute cerebrovascular events (p < 0.001). Rate of MACCE, bleeding and pericardial puncture were not influenced by the annual RA numbers per center.

Conclusion
MBs had a lower risk of bleeding and pericardial puncture. Patients treated at centers with high annual RA procedure numbers had a lower risk of acute cerebrovascular events and were hospitalized shorter.
Classification of hallux valgus deformity–is there a standard?
Authors: Spindler Fabian T. , Ettinger Sarah ,   D. A. F. Scientific committee, Stukenborg-Colsman Christina , Ochman Sabine , Rammelt Stefan , Polzer Hans , Gutteck Natalia , Harrasser Norbert , Plaass Christian , Baumbach Sebastian F. 
Published: September 2024

Abstract
Introduction
Hallux valgus deformity severity is one determent for the surgical procedure for hallux valgus (HV) correction. HV deformities are usually classified into mild/moderate/severe. The aim was to investigate the cut-off criteria used to classify HV deformity.

Materials and Methods
The study was based on a previous living systematic review. Four common databases were searched for the last decade. All review-steps were conducted by two reviewers. Data assessed were the individual cut-off values used to classify HV deformity into mild/moderate/severe, and the referenced classification systems.

Results
46 studies were included. 21/18 studies grade deformity based on the intermetatarsal angle (IMA)/ hallux valgus angle (HVA) with great heterogeneity throughout the different cut-off values. The most referenced classification systems were the Coughlin and Mann’s and the Robinson classification.

Conclusions
The currently used classification systems are heterogenic, and no standard could be defined. The community should define a uniform classification system.
Level of Evidence.
Level I, systematic review of randomized controlled trials and prospective comparative studies.
Better restoration of joint line obliquity in tibia first restricted kinematic alignment versus mechanical alignment TKA
Authors: Shichman Ittai , Hadad Aidan , Brandstetter Addy S. , Ashkenazi Itay , Warschwaski Yaniv , Gold Aviram , Snir Nimrod 
Published: September 2024

Abstract
Introduction
In total knee arthroplasty (TKA), suboptimal restoration of joint line obliquity (JLO) and joint line height (JLH) may lead to diminished implant longevity, increased risk of complications, and reduced patient reported outcomes. The primary objective of this study is to determine whether restricted kinematic alignment (rKA) leads to improved restoration of JLO and JLH compared to mechanical alignment (MA) in TKA.

Materials and Methods
This retrospective study assessed patients who underwent single implant design TKA for primary osteoarthritis, either MA with manual instrumentation or rKA assisted with imageless navigation robotic arm TKA. Pre- and post-operative long standing AP X-ray imaging were used to measure JLO formed between the proximal tibial joint line and the floor. JLH was measured as the distance from the femoral articular surface to the adductor tubercle.

Results
Overall, 200 patients (100 patients in each group) were included. Demographics between the two groups including age, sex, ASA, laterality, and BMI did not significantly differ. Distribution of KL osteoarthritis classification was similar between the groups. For the MA group, pre- to post-operative JLO significantly changed (2.94° vs. 2.31°, p = 0.004). No significant changes were found between pre- and post-operative JLH (40.6 mm vs. 40.6 mm, p = 0.89). For the rKA group, no significant changes were found between pre- and post-operative JLO (2.43° vs. 2.30°, p = 0.57). Additionally, no significant changes were found between pre- and post-operative JLH (41.2 mm vs. 42.4 mm, p = 0.17). Pre- to post-operative JLO alteration was five times higher in the MA group compared to the rKA group, although this comparison between groups did not reach statistical significance (p = 0.09).

Conclusion
rKA-TKA results in high restoration accuracy of JLO and JLH, and demonstrates less pre- and post-operative JLO alteration compared to MA-TKA. With risen interest in joint line restoration accuracy with kinematic alignment, these findings suggest potential advantages compared to MA. Future investigation is needed to correlate between joint line restoration accuracy achieved by rKA and enhanced implant longevity, reduced risk of post-operative complications, and heightened patient satisfaction.
Autonomic regulation and comorbid symptoms in children with attention deficit hyperactivity disorder
Authors: Kehm Kira , Schloß Susan , Mann Christopher , Becker Katja , König Udo , Pott Wilfried , Chavanon Mira-Lynn , Pauli-Pott Ursula 
Published: September 2024

Abstract

Objective
Vagally-mediated heart rate variability (vmHRV) is regarded as transdiagnostic marker of emotion regulation and cognitive control capacity. We analysed vmHRV of children with attention deficit/hyperactivity disorder (ADHD). Based on previous research, we expected to find comorbid symptom dimensions (i.e. internalizing symptoms, conduct problems (CP), and callous unemotional (CU) traits) to relate to vmHRV measures.

Methods
The sample comprised 100 (70 boys) medication naïve children with ADHD. Children were 6 to 11 years old. High frequency HRV (HF-HRV) was measured at rest and during a delay of gratification task. Additionally, sympathetic reactivity was assessed via skin conductance responses (SCR). Comorbid symptoms were assessed by parent-report questionnaires and clinical interviews.

Results
The multiple correlation between CU traits and the HF-HRV scores proved statistically significant. Higher CU traits were associated with higher HRV resting-state and response scores. CP were positively associated with the SCR score.

Conclusion
In children with ADHD, increased CU traits might point to a comparatively less impaired self-regulation capacity in the reward-related context. The result corresponds to findings from previous studies. In the future, CU traits should be considered in analyses of autonomic regulation in ADHD.
Sasaki versus Kähler groups
Authors: Kotschick D. , Placini G. 
Published: September 2024

AbstractWe study fundamental groups of compact Sasaki manifolds and show that compared to Kähler groups, they exhibit rather different behaviour. This class of groups is not closed under taking direct products, and there is often an upper bound on the dimension of a Sasaki manifold realising a given group. The richest class of Sasaki groups arises in dimension 5.
MicroRNA signatures in the pathogenesis and therapy of inflammatory bowel disease
Authors: Ramadan Yasmin N. , Kamel Ayat M. , Medhat Mohammed A. , Hetta Helal F. 
Published: September 2024

AbstractInflammatory bowel disease (IBD) is a persistent inflammatory illness of the gastrointestinal tract (GIT) triggered by an inappropriate immune response to environmental stimuli in genetically predisposed persons. Unfortunately, IBD patients' quality of life is negatively impacted by the symptoms associated with the disease. The exact etiology of IBD pathogenesis is not fully understood, but the emerging research indicated that the microRNA (miRNA) plays an important role. miRNAs have been documented to possess a significant role in regulating pro- and anti-inflammatory pathways, in addition to their roles in several physiological processes, including cell growth, proliferation, and apoptosis. Variations in the miRNA profiles might be a helpful prognostic indicator and a valuable tool in the differential diagnosis of IBD. Most interestingly, these miRNAs have a promising therapeutic target in several pre-clinical animal studies and phase 2 clinical studies to alleviate inflammation and improve patient's quality of life. This comprehensive review discusses the current knowledge about the significant physiological role of different miRNAs in the health of the intestinal immune system and addresses the role of the most relevant differentially expressed miRNAs in IBD, identify their potential targets, and emphasize their diagnostic and therapeutic potential for future research.
The vascular endothelial growth factor as a candidate biomarker of systemic lupus erythematosus: a GRADE-assessed systematic review and meta-analysis
Authors: Mangoni Arduino A. , Zinellu Angelo 
Published: September 2024

AbstractThere is an ongoing search for novel biomarkers of endothelial damage, active disease, and organ dysfunction in systemic lupus erythematosus (SLE). We investigated the role of the vascular endothelial growth factor (VEGF) as a candidate biomarker by conducting a systematic review and meta-analysis of studies examining VEGF concentrations in SLE patients and healthy controls. We searched electronic databases (PubMed, Scopus, and Web of Science) from inception to 31 May 2024 (inclusion criteria: VEGF measurement in SLE patients and healthy controls and SLE patients with and without active disease or specific organ dysfunction in case–control studies, recruitment of adult participants, and availability of the full text in the English language; exclusion criteria: non-case–control studies, participants under 18 years, articles reporting duplicate or irrelevant data, and animal studies). We assessed the risk of bias and the certainty of evidence using the JBI Critical Appraisal Checklist and GRADE, respectively (PROSPERO registration number: CRD42024561636). Circulating VEGF concentrations were significantly higher in SLE patients than in controls (22 studies; standardised mean difference, SMD = 0.71, 95% CI 0.44 to 0.98, p < 0.001; low certainty of evidence). In SLE patients, VEGF concentrations were significantly higher in those with active disease (six studies; SMD = 1.10, 95% CI 0.27 to 1.92, p = 0.009; very low certainty of evidence) and lupus nephritis (four studies; SMD = 0.80, 95% CI 0.03 to 1.57, p = 0.042; very low certainty of evidence). Only one study reported VEGF concentrations in SLE patients with and without pulmonary arterial hypertension. The effect size of the differences in VEGF concentrations between SLE patients and controls was not associated with disease duration, use of glucocorticoids and immunosuppressors, biological matrix assessed, or analytical method used. However, it was significantly associated with the study’s geographical location. The evidence was limited by the high but partially explainable heterogeneity and the presence of publication bias which was addressed with the “trim-and-fill” method (SLE presence), the high but partially explainable heterogeneity and lack of assessment of publication bias because of the limited study number (active disease), and the limited study number preventing the identification of sources of heterogeneity, sensitivity analysis, and assessment of publication bias (lupus nephritis). Our results highlight VEGF’s potential role as a SLE biomarker and the need for further research, also given the aforementioned limitations, investigating VEGF concentrations in a wide range of SLE patient subgroups.
Patterns of global and regional integration in the East African Community
Authors: Krantz Sebastian 
Published: September 2024

AbstractUsing detailed global trade and novel Multi-Region Input–Output data, this paper examines the East African Community’s (EAC) global and regional integration through trade, global, and regional value chains (GVCs and RVCs). With surgical attention to detail, the first part of the paper dissects key patterns and trends of EAC members’ participation in global and regional trade and production networks at the aggregate, bilateral, sectoral, and bilateral-sectoral levels. The second part then provides causal reduced-form evidence for the economic benefits of EAC integration through trade, GVCs, and RVCs at the sector level. Findings imply that the region is moderately integrated into GVCs and RCVs but shows no overall trend towards greater integration. Regional integration is advancing in agriculture and food processing, and Kenya is becoming a more dominant regional supplier of manufactures. Integration through trade and GVCs positively affects economic development in the region, particularly deeper forward GVC linkages in manufacturing. Deepening regional trade and forward linkages yields additional economic benefits vis-a-vis global linkages.