bluuebunny/crossref_metadata_2025_split huggingface dataset:
ANALYTICAL FORMULATION OF THE SINGLE-VISIT COMPLETENESS JOINT PROBABILITY DENSITY FUNCTION
Authors: Garrett Daniel , Savransky Dmitry 
Published: August 2016

ABSTRACT
We derive an exact formulation of the multivariate integral representing the single-visit obscurational and photometric completeness joint probability density function for arbitrary distributions for planetary parameters. We present a derivation of the region of nonzero values of this function, which extends previous work, and discuss the time and computational complexity costs and benefits of the method. We present a working implementation and demonstrate excellent agreement between this approach and Monte Carlo simulation results.
Migration of legacy data to new media formats for long-time storage and maximum visibility: Modern pollen data from the Canadian Arctic (1972/1973)
Authors: Nichols Harvey , Stolze Susann 
Published: August 2016

This Data Management Plan (DMP) was created using the DMPTool. It describes modern pollen data collected along a 2500 mile (~4000 km) transect in the Canadian Arctic in 1972/73 as part of an NSF funded research project (GB-33497). The project was undertaken at the Institute of Arctic and Alpine Research at the University of Colorado Boulder. This legacy dataset originally stored as a paper copy and on 35-mm film will be migrated to digital formats that allow upload of the dataset to an international open-access library for permanent storage and visibility. This DMP was submitted to the 2015 Best Digital Data Management Plan and Practices - Competition (https://data.colorado.edu/cudmpguidance).
The study provides a baseline pollen dataset for the interpretation of Holocene pollen diagrams from this region and for comparison with modern surface pollen samples, allowing the assessment of the effects of modern climate change on Arctic and subarctic ecosystems.
Benefits of a Culturally Tailored Health Promotion Program for Latino Youth With Disabilities and Their Families
Authors: Suarez-Balcazar Yolanda , Hoisington Molly , Orozco Alexander Agudelo , Arias Dalmina , Garcia Claudia , Smith Kayla , Bonner Briana 
Published: August 2016

Abstract
Little research is available about youth with disabilities, who experience numerous inequalities in health outcomes compared with youth without disabilities. Youth with disabilities experience many environmental and attitudinal barriers in maintaining healthy lifestyles, which put them at risk for obesity. Strong evidence has suggested that obesity rates are higher among youth with disabilities than among their nondisabled peers. The purpose of this study was to implement and examine the benefits of a culturally tailored healthy lifestyles program for Latino youth with disabilities and their families. Several cultural adaptations were made to align with the target population’s cultural norms. Seventeen Latino families identified 67 behaviors they wanted to change or new habits they wanted to establish. The postassessment data showed that several family routines improved, and families reported engaging in many of the healthy habits they had identified for themselves. Implications of culturally appropriate and accessible programming are discussed.
A new estimator of heat periods for decadal climate predictions – a complex network approach
Authors: Weimer Michael , Mieruch Sebastian , Schädler Gerd , Kottmeier Christoph 
Published: August 2016

Abstract. Regional decadal predictions have emerged in the past few years as a research field with high application potential, especially for extremes like heat and drought periods. However, up to now the prediction skill of decadal hindcasts, as evaluated with standard methods, is moderate and for extreme values even rarely investigated. In this study, we use hindcast data from a regional climate model (CCLM) for eight regions in Europe and quantify the skill of the model alternatively by constructing time-evolving climate networks and use the network correlation threshold (link strength) as a predictor for heat periods. We show that the skill of the network measure to estimate the low-frequency dynamics of heat periods is superior for decadal predictions with respect to the typical approach of using a fixed temperature threshold for estimating the number of heat periods in Europe.
Year-to-year correlation, record length, and overconfidence in wind resource assessment
Authors: Bodini Nicola , Lundquist Julie K. , Zardi Dino , Handschy Mark 
Published: August 2016

Abstract. Interannual variability of wind speeds presents a fundamental source of uncertainty in preconstruction energy estimates. Our analysis of one of the longest and geographically most widespread extant sets of instrumental wind-speed observations (62-year records from 60 stations in Canada) shows that deviations from mean resource levels persist over many decades, substantially increasing uncertainty. As a result of this persistence, the performance of each site's last 20 years diverges more widely than expected from the P50 level estimated from its first 42 years: half the sites have either fewer than 5 or more than 15 years exceeding the P50 estimate. In contrast to this 10-year-wide interquartile range, a 4-year-wide range (2.5 times narrower) was found for "control" records where statistical independence was enforced by randomly permuting each station's historical values. Similarly, for sites with capacity factor of 0.35 and interannual variability of 6  %, one would expect 9 years in 10 to fall in the range 0.32–0.38; we find the actual 90  % range to be 0.27–0.43, or three times wider. The previously un-quantified effect of serial correlations favors a shift in resource-assessment thinking from a climatology-focused approach to a persistence-focused approach: for this data set, no improvement in P50 error is gained by using records longer than 4–5 years, and use of records longer than 20 years actually degrades accuracy.
Merleau-Ponty and the Myth of Human Incarnation
Authors: Smyth Bryan 
Published: August 2016

ABSTRACT
In this article I argue that Merleau-Ponty's initial reinterpretation of Husserlian phenomenology is premised methodologically on a certain mythic understanding of human embodiment—what I term “the myth of human incarnation.” This is not an objection but a clarification of how Merleau-Ponty resolved the problem of the external horizonality of phenomenological experience on an intuitional (rather than speculative) basis. This methodological priority of myth is implicated in the epistemic status of phenomenological claims concerning prereflective phenomena such as “bodily” intentionality and thus has important consequences for questions concerning the “naturalization” of phenomenology.
Managing Risks and Stakeholders in the Design of a new Financial Product
Authors: Lanz Luciano Quinto , Tomei Patricia Amelia 
Published: August 2016

This article analyses risk’ and stakeholders’ management in the project to establish a product created by BNDES to provide partial credit guarantees for micro, small and medium enterprises (MSMEs), the Investment Guarantee Fund (FGI). The project went through several adjustments during its development to adapt it to changes in the credit market, the demands of financial agents and credit access’ public policy. For this analysis were used risk management models, stakeholder management in projects and guarantee systems. The methodology used was the single case study with the fund manager, with document analysis and semi-structured interviews. The results of the analysis indicate that the corrections in the direction and the adequacy of the fund project development pace, together with stakeholder management techniques use and project risk management, led to increased security in the Fund implementation, minimizing the need for rework and schedule delays. This context prevented several risks associated with the operation and the adequacy of the final product, contributing to a gradual but steady adoption of the Fund's guarantee by financial agents.
Update on the College of American Pathologists Experience With High-Risk Human Papillomavirus Proficiency Testing for Cytology
Authors: Ghofrani Mohiedean , Zhao Chengquan , Davey Diane D. , Fan Fang , Husain Mujtaba , Laser Alice , Ocal Idris T. , Shen Rulong Z. , Goodrich Kelly , Souers Rhona J. , Crothers Barbara A. 
Published: August 2016

Context.—Since 2008, the College of American Pathologists has provided the human papillomavirus for cytology laboratories (CHPV) proficiency testing program to help laboratories meet the requirements of the Clinical Laboratory Improvement Amendments of 1988.Objectives.—To provide an update on trends in proficiency testing performance in the College of American Pathologists CHPV program during the 4-year period from 2011 through 2014 and to compare those trends with the preceding first 3 years of the program.Design.—Responses of laboratories participating in the CHPV program from 2011 through 2014 were analyzed using a nonlinear mixed model to compare different combinations of testing medium and platform.Results.—In total, 818 laboratories participated in the CHPV program at least once during the 4 years, with participation increasing during the study period. Concordance of participant responses with the target result was more than 98% (38 280 of 38 892). Overall performance with all 3 testing media—ThinPrep (Hologic, Bedford, Massachusetts), SurePath (Becton, Dickinson and Company, Franklin Lakes, New Jersey), or Digene (Qiagen, Valencia, California)—was equivalent (P = .51), and all 4 US Food and Drug Administration (FDA)–approved platforms—Hybrid Capture 2 (Qiagen), Cervista (Hologic), Aptima (Hologic), and cobas (Roche Molecular Systems, Pleasanton, California)—outperformed laboratory-developed tests, unspecified commercial kits, and other (noncommercial) methods in ThinPrep medium (P &lt; .001). However, certain off-label combinations of platform and medium, most notably Cervista with SurePath, demonstrated suboptimal performance (P &lt; .001).Conclusions.—Laboratories demonstrated proficiency in using various combinations of testing media and platforms offered in the CHPV program, with statistically significant performance differences in certain combinations. These observations may be relevant in the current discussions about FDA oversight of laboratory-developed tests.
Molecular Testing of Thyroid Nodules: A Review of Current Available Tests for Fine-Needle Aspiration Specimens
Authors: Zhang Ming , Lin Oscar 
Published: August 2016

Context.—Fine-needle aspiration of thyroid nodules is a reliable diagnostic method to determine the nature of thyroid nodules. Nonetheless, indeterminate cytology diagnoses remain a diagnostic challenge. The development of multiplex molecular techniques and the identification of genetic alterations associated with different follicular cell–derived cancers in the thyroid have led to the introduction of several commercially available tests.Objective.—To summarize the most common commercially available molecular testing in thyroid cancer, focusing on the technical features and test performance validation.Data Sources.—Peer-reviewed original articles, review articles, and published conference abstracts were reviewed to analyze the advantages and limitations of the most common tests used in the evaluation of thyroid needle aspirations.Conclusions.—The most common tests available include the Afirma Gene Expression Classifier, ThyGenX, and ThyroSeq. The excellent negative predictive value (NPV) of the Afirma test allows it to be used as a “rule out” test. ThyGenX analyzes a panel of DNA mutations and RNA translocation fusion markers to assess the risk of malignancy with good NPV and positive predictive value. ThyroSeq is a next-generation sequencing–based gene mutation and fusion test that has been reported to have the best NPV and positive predictive value combined, suggesting that it can be used as a “rule in” and “rule out” test. Molecular testing of cytology specimens from thyroid nodules has the potential to play a major role in the evaluation of indeterminate thyroid lesions.
Autopsy and Postmortem Studies Are Concordant: Pathology of Zika Virus Infection Is Neurotropic in Fetuses and Infants With Microcephaly Following Transplacental Transmission
Authors: Schwartz David A. 
Published: August 2016

Context.—Pathology studies have been important in concluding that Zika virus infection occurring in pregnant women can result in vertical transmission of the agent from mother to fetus. Fetal and infant autopsies have provided crucial direct evidence that Zika virus can infect an unborn child, resulting in microcephaly, other malformations, and, in some cases, death.
Objective.—To better understand the etiologic role and mechanism(s) of Zika virus in causing birth defects such as microcephaly, this communication analyzes the spectrum of clinical and autopsy studies reported from fetuses and infants who developed intrauterine Zika virus infection, and compares these findings with experimental data related to Zika virus infection.
Design.—Retrospective analysis of reported clinical, autopsy, pathology, and related postmortem studies from 9 fetuses and infants with intrauterine Zika virus infection and microcephaly.
Results.—All fetuses and infants examined demonstrated an overlapping spectrum of gross and microscopic neuropathologic abnormalities. Direct cytopathic effects of infection by the Zika virus were confined to the brain; in cases where other organs were evaluated, no direct viral effects were identified.
Conclusions.—There is concordance of the spectrum of brain damage, reinforcing previous data indicating that the Zika virus has a strong predilection for cells of the fetal central nervous system following vertical transmission. The occurrence of additional congenital abnormalities suggests that intrauterine brain damage from Zika virus interferes with normal fetal development, resulting in fetal akinesia. Experimental in vitro and in vivo studies of Zika virus infection corroborate the human autopsy findings of neural specificity.
De la codépendance à l’indépendance
Authors: Faugier Étienne 
Published: August 2016

Comment le tourisme influence-t-il le transport ? Comment le transport influence-t-il le tourisme ? Comment démarre et comment se développe la coopération entre le tourisme et l’automobile dans la première moitié du XXe siècle ? Cet article entend montrer l’évolution des liens entre le tourisme et le transport en s’appuyant sur le cas de la province de Québec entre 1906 et 1936. Ce territoire constitue un exemple pertinent car durant cette période, le tourisme et la voirie se rejoignent pour former une politique étatique. Il s’agit d’en comprendre les origines, l’évolution et les conséquences que cela a pu avoir sur ces deux thématiques que sont le tourisme et le transport automobile.
À partir d’une recherche en histoire, l’article montre que les actions entreprises par les clubs automobiles de la province ont incité à l’essor du tourisme automobile. Puis, nous verrons que la pression associative amène l’État à participer activement au phénomène en devenant un des acteurs principaux de son élaboration à travers le ministère de la Voirie. La conclusion ouvre la réflexion sur l’historiographie.
Intermodalité, billettique et mobilité touristique
Authors: Salomon Christine 
Published: August 2016

La mobilité touristique constitue un enjeu essentiel du développement du tourisme urbain. La maîtrise des flux par les acteurs locaux renforce l’attractivité de la ville-centre de la destination et permet d’accroître sa fréquentation temporelle et spatiale par la diffusion des flux vers les sites périphériques. Elle suppose une offre de transport adaptée, leur gestion intégrée et la création d’un produit billettique servant l’intermodalité.
Cet article cherche à comprendre comment les grandes destinations urbaines construisent et gèrent leur « système logistique touristique » territorial. Les interrelations entre le réseau-système et le système de transport conditionnent l’accessibilité de la destination, aujourd’hui condition première, de l’attractivité devenue seconde.
Dans le cadre d’un travail de recherche en géographie, nous avons cherché à appréhender l’importance des mobilités touristiques dans le succès d’une destination à travers l’étude de l’impact de l’artecard, outil local de mobilité touristique, et son articulation avec d’autres produits. Cette analyse centrée sur l’outil billettique révèle les carences du système logistique touristique local et de sa gouvernance liées aux insuffisances du réseau-système et du réseau d’accessibilité générale.
La chaîne d’accessibilité, pivot de l’accès au Tourisme Handicap
Authors: Blaho-Ponce Claude 
Published: August 2016

L’une des dimensions les plus élémentaires du tourisme est l’action de voyager et de visiter un site pour son plaisir. Or, force est de constater que les départs en vacances pour les personnes en situation de handicap restent marginaux et bien souvent encore loin de portée. En fait, pour développer l’accès des personnes handicapées aux vacances et aux loisirs, il convient de mettre en oeuvre une réelle chaine touristique d’accessibilité dans les domaines de la vie quotidienne comme dans l’offre touristique standard. Ce processus est loin d’être enclenché ! Aujourd’hui, en France, à partir de la corrélation entre l’obligation réglementaire d’accessibilité, l’adaptation progressive des composantes de la chaîne touristique, les attentes de la clientèle handicapée et la certification nationale « Tourisme et handicap », se dessinent de nouvelles perspectives territoriales. Comment, dans la période actuelle, dépasser les frontières d’une mise en accessibilité fractionnée d’un lieu, d’un site, pour réaliser cette chaîne globale d’accessibilité d’un territoire, relier chaque maillon de la chaîne de consommation touristique et de vie quotidienne pour constituer une réelle offre de séjour à taille humaine ?
À partir de la littérature et d’une réflexion déductive, cet article, dans le champ de discipline de l’aménagement, vise à mieux faire comprendre les besoins des touristes handicapés, tenter de déterminer le principe des situations handicapantes, notamment l’interaction entre l’environnement, le contexte et le sujet handicapé, et pointer le besoin d’une information fiable et descriptive des sites et des équipements tout au long des composantes de la chaine touristique. Le principe d‘une chaine d’accessibilité territorialisée et adaptée au quotidien constitue le fondement de l’accès aux vacances et aux loisirs de la clientèle à besoins spécifiques.
Le camp de la jeunesse aux Jeux olympiques
Authors: Monnin Éric , Polycarpe Cyril 
Published: August 2016

L’analyse des camps de la jeunesse aux Jeux olympiques (JO) nous montre que les jeunes participants se rassemblent en proposant des activités spécifiques dans la connaissance et l’accessibilité de l’olympisme grâce à la culture de la ville accueillante. La spécificité de ces camps tient dans le fait qu’ils rassemblent les notions de lieu et de patrimoine culturel, tant pour l’histoire olympique que pour la ville hôte, conférant une tendance à la mondialisation des valeurs olympiques au service du méga-événement et du lieu organisateur. Le camp de la jeunesse devient un objet de transmission décliné en catégories diverses : géographie, culture, sport, etc. Il participe ainsi à la dynamique des territoires et de l’évènement olympique en tant qu’acteur du tourisme national par la mise en avant de son patrimoine et social, par la transmission de savoirs vernaculaires.
L’État et l’informalité en Amérique latine : virage à gauche. Changement de cap ?
Authors: Rebotier Julien 
Published: August 2016

La littérature en sciences sociales sur l’informalité en Amérique latine permet de suivre les pulsations de l’économie politique dans la région depuis les années 1970. Il en va de même pour les recompositions de la figure de l’État. L’attention portée aux liens entre les évolutions de l’informalité et les recompositions de l’État se concentre sur la période du « virage à gauche » des années 2000. Il en ressort le poids limité du retour récent et partiel de l’État, ainsi que celui, plus significatif, d’un grand récit libéral dans la définition de l’informalité et de sa portée dans la région aujourd’hui.
Les transmigrants colporteurs souterrains du capitalisme marchand moderne
Authors: Missaoui Lamia 
Published: August 2016

En contexte de globalisation, la dualité des économies bâties, d’une part, sur la classique verticalité des échanges internationalement régulés et, d’autre part, sur l’horizontalité « entre pauvres » hors contrôles étatiques, est mondialement apparue pour des produits vestimentaires et électroniques. C’est ainsi que des milliards de dollars de marchandises « d’entrée de gamme » produites dans le Sud-Est asiatique sont vendues sans taxes, via Dubaï, en Europe auprès des populations pauvres par des transmigrants moyen-orientaux. Cet article décrit, à partir d’une recherche récente (Tarrius, Missaoui et Qacha, 2013) comment ces transmigrants offrent aux grandes firmes mondiales le vaste marché des pauvres en passant en Europe des produits totalement hors taxes et hors contingentements. Cette description permet à l’auteur de discuter des notions clés qui rendent compte de ces divers phénomènes : initiatives économiques, invisibilisation, mobilités, conscience migratoire.
Investigation of the mechanisms of action behind Electromotive Drug Administration (EMDA)
Authors: Kos Bor , Vásquez Juan Luis , Miklavčič Damijan , Hermann Gregers G.G. , Gehl Julie 
Published: August 2016

ObjectiveBladder cancer is a cause of considerable morbidity worldwide. Electromotive Drug Administration is a method that combines intravesical chemotherapy with local electric field application. Electroporation has been suggested among other mechanisms as having a possible role in the therapy, so the goal of the present study was to investigate the electric fields present in the bladder wall during the treatment to determine which mechanisms might be involved.Material and MethodsElectromotive Drug Administration involves applying intravesical mitomycin C with direct current of 20 mA delivered through a catheter electrode for 30 min. For numerical electric field computation we built a 3-D nonhomogeneous patient specific model based on CT images and used finite element method simulations to determine the electric fields in the whole body.ResultsResults indicate that highest electric field in the bladder wall was 37.7 V/m. The mean electric field magnitude in the bladder wall was 3.03 V/m. The mean magnitude of the current density in the bladder wall was 0.61 A/m2.ConclusionsThe present study shows that electroporation is not the mechanism of action in EMDA. A more likely explanation of the mechanism of action is iontophoretic forces increasing the mitomycin C concentration in the bladder wall.