bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of transcutaneous electrical nerve stimulation therapy on condylar position and myofascial pain in patients with temporomandibular joint disorders—A pilot clinical trial
Authors: Rebekah R , Navaneethan R , Nagachandran KS 
Published: September 2024

OBJECTIVE:
Temporomandibular joint disorders (TMD) are a type of disorder that affects the temporomandibular joint, muscles, and nerves leading to persistent facial pain. Transcutaneous electrical nerve stimulation (TENS) therapy is an alternative treatment for pain relief in TMD patients. The aim of the study was to assess the condylar position changes and pain levels occurring in TMD patients after TENS therapy.

MATERIALS AND METHODOLOGY:
According to the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) criteria, a total of seven patients with TMD were included in this study. Routine diagnostic investigations were taken for each patient along with joint vibration analysis (JVA), electromyography (EMG), and a cone beam computed tomography (CBCT) at rest position. Using the Dolphin software (version 11.95), the temporomandibular joint spaces were measured on the CBCT for the right and left sides individually for each patient. These patients were then subjected to TENS therapy, and an EMG reading was taken post-TENS therapy to evaluate the effect on muscle strain. A CBCT was taken after the TENS therapy to assess its effect on the condylar position. The statistical significance of the pre- and post-temporomandibular joint spaces and the EMG readings post-TENS therapy were assessed using paired t-tests, respectively.

RESULTS:
There was a change in the anterior, middle, and posterior dimensions observed radiographically, before and after TENS. However, the results were found to be statistically significant only in the anterior region on the right joint space (P = 0.03) and posterior region of the left joint space (P = 0.04).

CONCLUSION:
TENS therapy has been found to bring about a change in the condylar position and pain intensities by relieving inadvertent muscle activity in the temporomandibular region. Therefore, further studies with larger sample sizes and control are required to fully ascertain the role of inadvertent muscle activity on the TMJ.
Evaluation of surface roughness, cytotoxicity, and antibacterial effects of silver nanoparticle coating on copper nickel titanium orthodontic arch wires – in vitro study
Authors: Anishya Daphane , Jain Ravindra K. 
Published: September 2024

BACKGROUND:
Surface roughness of arch wires directly impacts their corrosion behavior, friction resistance, and plaque accumulation, which may hinder tooth movement and lead to dental caries.

OBJECTIVES:
The study aims to synthesize vanillin-mediated silver nanoparticles (AgNPs), characterize them, assess surface roughness and cytotoxicity of arch wires after silver nanoparticle coating, and test their antibacterial properties.

MATERIALS AND METHODS:
Nine copper–nickel–titanium arch wires (CuNiTi) were cut into equal pieces. Three were sent for surface roughness assessment, three for cytotoxicity, and three for antibacterial testing. Dip coating of wires was done using the sol–gel thin film method. The surface roughness (Ra) before and after coating was evaluated using scanning electron microscopy and atomic force microscopy. Cytotoxicity testing was done with a (3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay using gingival fibroblasts. Statistical analysis was done using SPSS software. Antibacterial activity against S. mutans was tested using the Agar-well diffusion method.

RESULTS:
The CuNiTi wires were coated successfully, and the coating appeared homogeneous. The mean Ra after coating (297.3+/- 30.4 nm) was significantly less than that before coating (339.7+/-49.2 nm). AgNPs showed minimal cytotoxicity against human gingival fibroblasts at different concentrations. Optical microscopy showed over 90% viability between 12.5 and 100 µg/ml. At 100 µg/ml, only 80% of cells remained viable. AgNP coating is biocompatible at concentrations up to 75 µg/ml. There was a significant intergroup difference in the zone of inhibition (antibacterial activity) noted with higher values in noncoated wires. (P value <0.007).

CONCLUSION:
AgNPs coated on CuNiTi arch wires showed reduced surface roughness and minimal cytotoxic effects on human gingival cells and good antibacterial activity against S. mutans compared to noncoated arch wires.
Determinants of decision-making in biopsy of PI-RADS 3 transition zone lesions
Authors: Wee Nicole Kessa , Tan Cher Heng , Choo Zhen Wei , Lee Chau Hung 
Published: September 2024

Abstract

Introduction:
Cancer rates for Prostate Imaging-Reporting and Data System (PI-RADS) 3 lesions are low. We aimed to determine the clinical and magnetic resonance imaging (MRI) parameters that can provide risk stratification for PI-RADS 3 transition zone (TZ) lesions to guide decision for biopsy, which can improve the cost-effectiveness of resource utilisation.

Methods:
The MRI scans of all patients who underwent MRI–ultrasound fusion targeted biopsy from 1 May 2016 to 31 December 2022 were retrospectively assessed by two board-certified abdominal radiologists. The following data were collected and analysed serum prostate-specific antigen, Prostatic Health Index (PHI), prostate volume, histological results, lesion size, location, diffusion-weighted imaging (DWI) parameter scores and overall PI-RADS score.

Results:
Two hundred and fourteen TZ lesions were included. Among 131 PI-RADS 3 lesions, those with marked restricted diffusion (DWI score ≥4), diameter ≥1 cm, prostrate-specific antigen density (PSAD) ≥0.11 and PHI ≥34 were more likely to contain clinically significant prostate cancer (csPCa; P = 0.04, 0.02, 0.049 and 0.05, respectively), with areas under the receiver operating characteristics curve of 0.9, 0.76, 0.84 and 0.80, respectively. Apical lesions were more likely to contain csPCa compared to midgland or basal lesions (P = 0.01).

Conclusion:
Clinical parameters (PSAD and PHI) and MRI features (lesion size, DWI score, lesion location) can be used to risk stratify PI-RADS 3 TZ lesions and guide decision for targeted biopsy.
Clinical Features of Behçet’s Disease Uveitis
Authors: Yalçindag Nilüfer , Oklar Murat 
Published: September 2024

Abstract:
Behçet’s disease (BD) is a chronic, multisystemic vasculitis first described by Professor Hulusi Behçet in 1937. It is characterized by recurrent inflammatory attacks affecting multiple organs, with uveitis being a significant and severe complication that can lead to blindness. BD typically emerges between the ages of 20 and 30 years, with a higher prevalence in males and rare occurrences in children. The prevalence and severity of BD and its ocular symptoms tend to diminish with age. In Turkey, BD is a leading cause of noninfectious uveitis, and its prevalence varies across different regions. Ocular involvement, seen in up to 90% of BD patients, often appears 2–4 years after disease onset and may be the initial sign in 10%–20% of cases. BD uveitis is characterized by recurrent nongranulomatous panuveitis and retinal vasculitis, typically affecting both eyes. Diagnostic tools such as fluorescein angiography (FA), optical coherence tomography (OCT), and laser flare photometry (LFP) are essential for monitoring disease activity and guiding treatment. FA is crucial for identifying occlusive and leaky vasculitis, while OCT helps in detecting macular complications and visualizing retinal infiltrates and their sequelae. LFP quantitatively evaluates intraocular inflammation. Recognizing the ocular manifestations of BD early is vital for accurate diagnosis and effective management. This review highlights the clinical features, diagnostic tools, and importance of early diagnosis in managing BD uveitis.
“Don’t miss the globe” – Study of diagnostic accuracy of computed tomography in detecting open globe injury
Authors: George Georgina , Monteiro Berton C. , Noronha Dilon D. , Mijar Mahesh , Karanth Krishna K. S. 
Published: September 2024

Abstract:

PURPOSE:
The purpose is to determine the computed tomography (CT) characteristics of open globe injury and establish the relative accuracy and reliability of various features on CT. Second, to assess the significance of a difference in the anterior chamber depths (ACDs) on CT in cases of open globe injury.

METHODS:
The diagnostic database of our radiology department was retrospectively reviewed to obtain details of patients with a history of blunt or penetrating injury to the orbit between September 2018 and March 2021. A total of 190 patients (144 males and 46 females) were included. A radiologist analyzed the CT scans without prior knowledge of ophthalmologic findings or surgical outcomes. Operative and ophthalmic examination findings were considered the gold standard for comparison.

RESULTS:
Out of 190 injured globes, the final clinical diagnosis confirmed 54 (28.4%) open globe injuries and 136 (71.5%) closed globe injuries. Between the two groups, intraocular hemorrhage, lens dislocation, lens injury or absence, intraocular foreign body, intraocular air, wall/contour defect, and ACD change were considered statistically significant (P < 0.05). The average sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of CT in diagnosing open globe injury were 71.3%, 98.5%, 83.6%, 95.75%, and 94.9%, respectively.

CONCLUSION:
Globe contour deformity or defect, intraocular hemorrhage, and a change in ACD were the three most predictive signs of open globe injury. CT is of valuable help in a multi-trauma setting and in an uncooperative patient for ophthalmological examination to draw attention to globe injury. However, CT examination alone is insufficient in detecting all cases of open globe injury. There is a need for a more collaborative approach among emergency physicians, ophthalmologists, and radiologists.
Cataract surgery with corneal endothelial pathology
Authors: Chaudhari Isha , Mehta Jodhbir S. 
Published: September 2024

Abstract:It is not uncommon for Fuch’s endothelial corneal dystrophy (FECD) patients to present with a co-existent cataract. Surgeons are often faced with a choice between simultaneous and staged corneal and cataract surgery. Descemet’s membrane endothelial keratoplasty (DMEK) has been found to have better visual outcomes as compared to Descemet’s stripping endothelial keratoplasty (DSEK) and penetrating keratoplasty and is currently the preferred surgery for FECD. Endothelial cell count and pachymetry cutoffs were earlier used for decision-making. Various other investigations such as Scheimpflug imaging and confocal microscopy are now used to prognosticate the outcome when performing cataract surgery only. Triple DMEK has the advantage of a definite treatment in a single sitting. Whereas, a staged approach with DMEK followed by cataract surgery has a better visual outcome. This is due to variable refractive changes in the cornea post-DMEK or DSEK that can lead to inaccurate intraocular lens (IOL) power calculation. Even though the graft detachment rates and rebubbling rates have been found to be comparable in triple DMEK versus a staged surgery, in view of increasing patient demands and expectations for a spectacle-independent outcome, a staged surgery is now preferable. Conventionally, surgeons favored the use of only monofocal lenses; however, the use of premium IOLs, especially extended depth of focus lenses, is now increasing. In this review, we will discuss the various advantages and disadvantages of a simultaneous and staged approach and pearls on decision-making in FECD with cataracts.
ANALISIS PENGARUH CURRENT RATIO, RETURN ON ASSETS, DEBT TO EQUITY RATIO, DAN TOTAL ASSETS TURN OVER TERHADAP PERTUMBUHAN LABA PERUSAHAAN PERTAMBANGAN BATU BARA TAHUN 2017-2022 DENGAN COMPANY SIZE SEBAGAI VARIABEL MODERASI
Authors: Wiguna Nanda Shautiya , Hakim Lukman 
Published: September 2024

This study aims to analyze the effect of current ratio, return on assets, debt to equity ratio, and total assets turn over on profit growth of coal mining companies in 2017-2022 with company size as a moderating variable. This research method is quantitative. This research data is secondary data. The secondary data used in this study consists of published financial reports of mining companies. In addition, the official website of the Indonesia Stock Exchange (IDX). The population in this study were coal sector mining companies in the 2017-2020 period, totaling 5 of the 19 coal sector companies on the Indonesia Stock Exchange (IDX). In this study, the sampling used was purposive sampling technique. . This research data analysis technique with the help of SPSS software. The results of this study are that the Current ratio has a significant impact and has a negative effect on the profit growth of coal companies. Return on assets has a negative and significant effect on the profit growth of coal companies. Debt to equity ratio has a positive and significant impact on profit growth. Total assets turnover has a positive but insignificant impact on earnings growth. Company size cannot moderate the current ratio on the profit growth of coal companies. Company size is able to moderate the impact of return on assets on the profit growth of coal companies. Company size is able to moderate the debt to equity ratio on the profit growth of coal companies. Company size is unable to moderate total assets turnover on the profit growth of coal companies
PENGARUH KESADARAN WAJIB PAJAK DAN PENGETAHUAN PERPAJAKAN TERHADAP KEPATUHAN WAJIB PAJAK DALAM MEMBAYAR PAJAK BUMI DAN BANGUNAN
Authors: Asfira Asfira , Rijal Abdul , Hamzah Hajrah 
Published: September 2024

This research aims to analyze to analyze the influence of taxpayer awareness and tax knowledge towards Taxpayer Compliance in Paying Land and Building Taxes in East Tonrokassi Village, Tamalatea District, Jeneponto Regency. The population in this research is land and building tax payers in East Tonrokassi Village, Tamalatea District, Jeneponto Regency. The population in this study was 2698 Taxpayers. while the sample was 97 taxpayers taken using a non-probability sampling technique using a purposive sampling method. Data collection was carried out using questionnaires. The data analysis used is instrument testing, classical assumption testing, and hypothesis testing using SPSS v. 25 for windows. The results of this research show that Taxpayer Awareness and Tax Knowledge influence taxpayer compliance in paying Land and Building Tax in East Tonrokassi Village, Tamalatea District, Jeneponto Regency
ANALISIS PENGARUH MANAJEMEN MODAL KERJA TERHADAP PROFITABILITAS: STUDI KASUS PADA RUMAH SAKIT X
Authors: Ayuntari Chivalrind G , Wahyuningrum Dwi Sari 
Published: September 2024

This study aims to analyze the effect of working capital management on profitability in X Hospital. The research method used is descriptive quantitative. The data source used comes from secondary data in the form of financial statements of Hospital X for the period 2020 - 2022. Working capital analysis is carried out by analyzing financial ratios using cash turnover, accounts receivable turnover, and inventory turnover ratios. Meanwhile, to analyze profitability, the ratios of return on assets (ROA), return on equity (ROE,) and net profit margin (NPM) were used. The results showed that working capital management has a significant effect on profitability
Survival in myotonic dystrophy type 1: a long time follow up-study with special reference to gastrointestinal symptoms
Authors: Rönnblom Anders , Ekbom Anders 
Published: September 2024

Background: Myotonic dystrophy type 1 (DM1) is a monogenetic disease affecting many organs. Gastrointestinal symptoms are prevalent and of considerable consequences for affected individuals. The life expectancy is shortened and the objective of the study is to evaluate if gastrointestinal symptoms can predict the outcome of the disease.
Method: Fifty-one patients with DM1 were interviewed regarding symptoms from the gastrointestinal tract in the mid-1990s. Survival of all patients was evaluated in 2023 and the impact of symptoms on survival was assessed.
Results: At the beginning of the study, the mean age was 35.9 years, (median 37.0, 9–63). At the end of the study 47 out of the 51 patients were deceased at a mean age of 53.7 years (median 55.7, 32.5–79.0). Patients with the congenital form of DM1 (n = 6) died at an age of 46.0 years (median 45.2, 40.0–53.6). There was no correlation between the gastrointestinal symptoms and survival.
Conclusion: Albeit prevalent and of considerable clinical consequence, gastrointestinal symptoms are not correlated to survival in myotonic dystrophy type 1.
Pokomunistinio tranzito buvusios SSRS valstybėse vaizdinys
Authors: Šermukšnytė Rūta 
Published: September 2024

Aptariama kultūros istorikės Rasos Čepaitienės monografija „Postsovietinis tranzitas: nuo Sovietų Sąjungos žlugimo iki karo Ukrainoje: atmintis, paveldas, tapatumas buvusioje SSRS“ (Kaunas: Obuolys, 2022) lietuviškoje istoriografijoje išsiskiria šiais požymiais: 1) daugiakultūriu (tyrimo erdvė – buvusios SSRS teritorijoje susikūrusios valstybės); 2) tarpdisciplininiu (tyrime naudojamos įvairios humanitarinių ir socialinių mokslų teorijos, prieigos); 3) sintezės (knygoje pateikiamas tam tikras posovietinės transformacijos buvusios SSRS teritorijoje susikūrusiose valstybėse vaizdinys). Monografijoje pagrindinis dėmesys sutelkiamas į įvairias institucijas, priemones, strategijas ir asmenybes, dalyvavusias formuojant buvusios SSRS teritorijoje gyvenančių visuomenių atmintį apie sovietmetį. Tai mąstyti provokuojantis, toliau gilintis, klausti ir ieškoti atsakymų skatinantis veikalas.
USO DE TECNOLOGIAS PELOS PROFESSORES: CAPACITAÇÃO DE PROFESSORES PARA A UTILIZAÇÃO EFICAZ DAS TICS (TECNOLOGIAS DA INFORMAÇÃO E COMUNICAÇÃO) NO ENSINO
Authors: Giovanelli Roberta Preissler Marcolino , Coutinho Diógenes José Gusmão 
Published: September 2024

O estudo tem como tema o uso da tecnologia na educação a partir do ponto de vista da atuação dos professores. Tendo como intuito investigar a importância da capacitação dos profissionais da educação, especificamente, os professores que utilizam ferramentas da tecnologia digital. O foco principal foi investigar os impactos da inserção da tecnologia digital na dinâmica de trabalho e atuação dos docentes. Deve-se reconhecer que o uso da tecnologia em ambientes escolares ainda é tema controverso porque traz à tona muitos problemas enfrentados a falta de recursos presentes na educação no Brasil e inexperiência. As escolas precisam estar preparadas para acolher tais recursos de forma efetiva, buscando atender às necessidades dos alunos. A introdução da tecnologia nos ambientes escolares apresenta inúmeros desafios para os professores, pois eles são os responsáveis pela inserção da tecnologia no processo de ensino e aprendizagem. Em relação à metodologia, a pesquisa utilizada baseou-se em revisão bibliográfica, possui método de abordagem de pesquisa qualitativa, através do método de abordagem dedutivo. As questões centrais deste estudo são baseadas na falta de conhecimento e profundidade da compreensão dessas ferramentas e na falta de investimento por parte das instituições responsáveis. Conclui-se que há necessidade de maiores investimentos em educação e que o uso de tecnologias são importantes ferramentas de aprendizagem.
Gregorio de Santiago Vela (1865-1924), insigne biógrafo, bibliógrafo e historiador, en el primer centenario de su muerte
Authors: Lazcano González Rafael 
Published: September 2024

Con motivo del primer centenario de la muerte del ilustre bibliógrafo Gregorio de Santiago Vela (1865-1924), el autor del presente estudio expone las notas predominantes de su vida, nacimiento, estudios, formación agustiniana y eclesiástica, actividad misionera en Filipinas y labor cultural, realizada con tanto afán y método que le han convertido en uno de los grandes bibliógrafos de la Orden de San Agustín y de España, aunque su conocimiento y estudio sea todavía limitado.Además de editor y primer director de la revista Archivo Agustiniano, entonces bimestral y titulada Archivo Histórico Hispano-Agustiniano (1914-1924), de 128 páginas cada número, donde la mayor parte de sus numerosos y meritorios trabajos de historia agustiniana, es autor del Ensayo de una Biblioteca iberoamericana de la Orden de San Agustín (Madrid 1913-1931), proyectada en 8 tomos, si bien el cuarto quedó inédito. El Ensayo, obra bio-bibliográfica de gran amplitud, solidez y perfección, está posicionado muy por encima de las realizadas hasta entonces con semejantes características. En ella no solo abundan los datos novedosos, tanto de vidas como de obras impresas e inéditas, sino que ofrece con rigor, método y criterio innumerables hitos y acontecimientos históricos, sociales, religiosos y culturales, así como la descripción física de algunos miles de libros y sus contenidos, ediciones, traducciones, etc. En el plano crítico sobresale por sus juicios luminosos, profundos y certeros, señal inequívoca de un intenso estudio, erudición y labor bibliográfica.
Pediatric puzzle: Large ovarian dermoid cyst and markedly elevated CA 19-9 in an 8-year-old
Authors: Abdelmoaty Muhamed Ahmed , Taha Wael Soliman 
Published: September 2024

Background: Mature cystic teratomas, also known as dermoid cysts, are the most prevalent form of ovarian germ cell tumors. While they typically manifest in women of reproductive age, they can also occur in pediatric patients. These tumors are generally benign and comprise a diverse array of tissue types. However, large lesions, particularly those exceeding 10 cm in diameter, are infrequent and can present diagnostic and therapeutic challenges. Notably, elevated tumor markers, such as cancer antigen 19-9 (CA 19-9), are not commonly associated with mature cystic teratomas, rendering this case particularly unusual.
Case presentation: The clinical case involved an 8-year-old female patient who presented with an exceptionally large ovarian teratoma, measuring 13 × 12 cm. While the prepubertal presentation of such tumors is not uncommon, the remarkable size of the lesion was an extraordinary occurrence. Preoperative evaluation revealed markedly elevated levels of CA 19-9, a tumor marker, at 297 U/mL—an atypical finding for mature cystic teratomas. Imaging studies identified a complex cystic adnexal mass, indicative of a teratoma. Consequently, a laparotomy was performed, revealing an intact, benign lesion that was successfully resected via cystectomy, with preservation of the ovary. Histopathological examination confirmed the diagnosis of a mature cystic teratoma, without any evidence of malignant transformation. Notably, following the surgical intervention, the elevated CA 19-9 levels normalized, suggesting a potential association between the teratoma and the abnormal tumor marker levels.
Discussion: This report delineates the surgical management and clinical course of an exceptionally large ovarian teratoma in a pediatric patient with abnormal preoperative tumor markers. Despite atypical features, the excellent prognosis following fertility-sparing resection underscores the significance of conservative treatment in young females.
Conclusion: This case highlights the occurrence of a large mature cystic teratoma with elevated CA-19-9 in a pediatric patient with no complications such as torsion, rupture, or malignancy. The elevation in CA-19-9 likely relates directly to the teratoma itself. A conservative, fertility-sparing surgical approach proved effective, emphasizing the importance of careful preoperative evaluation and management in similar cases.