bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive Behavioral Therapy plus Amitriptyline for Children and Adolescents with Chronic Migraine Reduces Headache Days to ≤4 Per Month
Authors: Kroner John W. , Hershey Andrew D. , Kashikar‐Zuck Susmita M. , LeCates Susan L. , Allen Janelle R. , Slater Shalonda K. , Zafar Marium , Kabbouche Marielle A. , O'Brien Hope L. , Shenk Chad E. , Rausch Joseph R. , Kroon Van Diest Ashley M. , Powers Scott W. 
Published: March 2016

ObjectiveThe objective of this secondary analysis of results from a previously published trial (Clinical Trials Registration Number: NCT00389038) in chronic migraine in children and adolescents was to examine if participants who received cognitive behavioral therapy and amitriptyline reached a greater level of reduction in headache frequency that no longer indicated a recommendation for preventive treatment as compared to those who received headache education and amitriptyline.BackgroundChronic migraine negatively affects children's home, school, and social activities. Preventive medication therapy is suggested for 5 or more headaches per month. Reduction to one headache day per week or less may suggest that preventive treatment is no longer indicated and provide a clinically relevant outcome for treatment efficacy and patient care.MethodsRandomized study participants (N = 135) kept a daily record of their headache frequency during 20 weeks of treatment and during a 1 year follow‐up period. Baseline headache frequency was determined at the end of a 28 day screening period. Post treatment frequency was determined at 20 weeks (N = 128 completed) and post treatment follow‐up was measured 12 months later (N = 124 completed). A chi‐square test of independence was conducted by treatment group and by time point to determine group differences in the proportion of headache days experienced.ResultsAt 20 weeks (post treatment), 47% of the cognitive behavioral therapy plus amitriptyline group had ≤4 headache days per month compared to 20% of the headache education plus amitriptyline group, (P = .0011), and 32% of the cognitive behavioral therapy plus amitriptyline group had ≤3 headache days per month at 20 weeks compared to 16% of the headache education plus amitriptyline group, (P = .0304). At the month 12 follow‐up, 72% of the cognitive behavioral therapy plus amitriptyline group had ≤4 headache days per month compared to 52% of the headache education plus amitriptyline group, (P = .0249), and 61% of the cognitive behavioral therapy plus amitriptyline group had ≤3 headache days per month at their month 12 follow‐up compared to 40% of the headache education plus amitriptyline group, (P = .0192).ConclusionsParticipants who received cognitive behavioral therapy and amitriptyline were more likely than participants who received headache education plus amitriptyline to reach the clinically meaningful outcome of less than or equal to 4 headache days per month at both time points. These results may help inform what treatment outcomes are possible for children and adolescents suffering from chronic migraine and provides further evidence for behavioral treatment to be considered as a key part of a first line treatment regimen.
A successful case of deceased donor liver transplantation for a patient with intrahepatic arterioportal fistula
Authors: Takagi Kosei , Yagi Takahito , Yoshida Ryuichi , Shinoura Susumu , Umeda Yuzo , Nobuoka Daisuke , Watanabe Nobuyuki , Kuise Takashi , Sui Kenta , Hirose Akira , Tsuboi Makiko , Ogasawara Mitsunari , Iwasaki Shinji , Saibara Toshiji , Fujiwara Toshiyoshi 
Published: March 2016

Intrahepatic arterioportal fistula (IAPF) is a rare cause of portal hypertension that is often difficult to treat with interventional radiology or surgery. Liver transplantation for IAPF is extremely rare. We report a case of bilateral diffuse IAPF with severe portal hypertension requiring deceased donor liver transplantation (DDLT). A 51‐year‐old woman with no past medical history was admitted to another hospital complaining of abdominal distension and marasmus. A computed tomography scan and digital subtraction angiography indicated a massive pleural effusion, ascites, and a very large IAPF. Several attempts of interventional embolization of the feeding artery failed to ameliorate arterioportal shunt flow. As ruptures of the esophageal varices became more frequent, hepatic encephalopathy worsened. After repeated, uncontrollable attacks of hepatic coma, the patient was referred to our facility for further treatment. Surgical approaches to IAPF other than liver transplantation were challenging because of diffuse collateralization; therefore, we placed the patient on the national waiting list for DDLT. Although her Model for End‐Stage Liver Disease score was relatively low, she received a DDLT 2 months after the waiting period. The postoperative course was uneventful, and the patient was discharged 44 days after her transplant. Liver transplantation may be a valid treatment option for uncontrollable IAPF with severe portal hypertension.
Prevalence of apical periodontitis and root filled teeth in a Belgian subpopulation found on CBCT images
Authors: Van der Veken D. , Curvers F. , Fieuws S. , Lambrechts P. 
Published: March 2016

AbstractAimTo investigate the prevalence of apical periodontitis (AP) and root filled teeth found on cone‐beam computed tomography (CBCT) scans in a Belgian subpopulation in a retrospective cross‐sectional study.MethodologyAt the university hospital of Leuven, 804 patients received a CBCT scan between 01/01/2013 and 01/01/2014. The investigated sample included 631 scans with a permanent dentition and a total of 11 117 teeth. Prevalences and their confidence intervals are reported and the association between treatment, position of a tooth, gender and age with AP was determined using logistic regressions.ResultsA total of 656 teeth (5.9%) had signs of AP and 1357 teeth (12.2%) had been root filled. AP was present in 212 of the 9760 nonroot filled teeth (2.2%) and in 444 of the 1357 root filled teeth (32.7%). Adequate root fillings were detected in approximately half (49.3%) of the root filled teeth. The prevalence of AP was 22.8% when the root filling was adequate, when scored inadequate the prevalence increased to 41%. Univariate and multivariable logistic regression analyses revealed a significant relation of tooth position and treatment with AP. No difference in the prevalence of AP between male and female patients was detected.ConclusionThe prevalence of AP was comparable with findings in other epidemiological studies. Root filled teeth had significantly more AP than nonroot filled teeth. The technical quality of the root fillings had a significant impact on the presence of AP. Therefore, emphasis on the quality of work and continuing education in the field of Endodontology must be provided in Belgium.
Diffusion of antimicrobials in multispecies biofilms evaluated in a new biofilm model
Authors: van der Waal S. V. , de Almeida J. , Krom B. P. , de Soet J. J. , Crielaard W. 
Published: March 2016

AbstractAimTo describe the application of a newly‐developed in vitro model in which the diffusion of antimicrobials in oral biofilms can be studied.MethodologyIn a flow chamber consisting of three parallel feeding channels connected with each other by eight perpendicular side channels, multispecies biofilms were grown from saliva of a single donor for 48 h. The dimensions of the side channels were 100 μm × 100 μm × 5130 μm (H × W × L). When one or more side channels were filled with biofilm, the biofilms were stained with fluorescent stains. Then, one side‐channel biofilm was selected and treated with phosphate buffered saline, 2% sodium hypochlorite (NaOCl), 17% ethylenediaminetetra‐acetic acid (EDTA) or modified salt solution (MSS). Diffusion of the irrigants was observed by acquiring fluorescence images at 10× objective every 15 s for 30 min.ResultsIt was possible to culture biofilms in the narrow (100 μm) channels. The biofilms varied in phenotype. In this model, no diffusion of NaOCl into the biofilms was seen after its application. Seventeen‐percentage EDTA only diffused into the biofilm up to 200 μm in 30 min. MSS did diffuse in the biofilm over a distance of 450 μm within 2 min after a single application.ConclusionsThis new model enables the investigation of the diffusion of antimicrobials in biofilms. Other applications to improve our understanding of the characteristics of biofilms are now possible.
Comparing the differences of characteristic flavour between natural maturation and starter culture for Mucor‐type Douchi
Authors: He Guiqiang , Huang Jun , Liang Ru , Wu Chongde , Zhou Rongqing 
Published: March 2016

SummaryIn this research, effects of maturation times on volatiles of Mucor‐type Douchi were investigated. Results showed that 2‐year matured sample exhibited higher concentrations of characteristic flavours including alcohols, esters, phenols, ketones and pyrazines. Additionally, effects of starter cultures addition on volatiles were investigated, and results demonstrated that inoculated fermented samples presented higher amounts of aldehydes, ketones, phenols and pyrazines compared with that of naturally fermented sample. Analysis of odour activity value (OAV) suggested that increased OAVs of eight compounds that mainly contributed to the flavour of Douchi ranged from onefold to 6.5‐fold in the Tetragenococcus halophilus, Zygosaccharomyces rouxii and Candida versatilis co‐cultured sample. Furtherly, by comparing the characteristic flavour of co‐cultured and 2‐year matured samples, no significant difference was observed in the OAV of flavour except rose‐like and soapy flavour, which indicated that co‐culture of the three strains during Douchi fermentation may facilitate the formation of flavours and shorten the fermentation process.
Comparative studies of quality changes in white and dark muscles from common carp (Cyprinus carpio) during refrigerated (4 °C) storage
Authors: Li Qian , Li Dongping , Qin Na , Hong Hui , Luo Yongkang 
Published: March 2016

SummaryDifferences between white and dark muscles from common carp (Cyprinus carpio) in sensory assessment, total viable counts (TVC), total volatile basic nitrogen (TVB‐N), pH, electrical conductivity (EC), biogenic amines (BAs), nucleotide degradation products and colours were investigated under air and vacuum conditions during refrigerated (4 °C) storage. Compared with white muscle, dark muscle had a higher lipid content, but lower crude protein and moisture content. TVC, TVB‐N, pH, and L* value were higher in white muscle, while K value and a* value were higher in dark muscle. Under both conditions, white and dark muscles had significant (P < 0.05) differences in tyramine and cadaverine content. Although dark muscle was significantly (P < 0.05) lower in ATP content, it had higher rate of IMP degradation and K value increase. Taking sensory and microbial indexes into consideration, dark muscle appeared to have a longer shelf life than white muscle under both conditions.
Interactions between maternal killer cell immunoglobulin receptor genes and foetal HLA ligand genes contribute to type 1 diabetes susceptibility in Han Chinese
Authors: Sun C. , Sanjeevi S. , Luo F. , Zhi D. , Sanjeevi C. B. 
Published: March 2016

SummaryIn this study, we aimed to test the hypothesis that KIR haplotypes (that interact with HLA class I molecules) are associated with susceptibility in patients with T1DM in utero through maternal–foetal interaction of KIR and their HLA class I ligands in Han Chinese population. We determined the KIR genes and KIR/ligand gene combination frequencies in 59 Han Chinese children with T1D and their mothers and compared it with 159 healthy control children and their mothers. The absence of KIR‐2DS1 in the mother and the presence of HLA‐C2 ligand in the child were negatively associated with type 1 diabetes in the child. Our results indicate that maternal KIR genes and their interaction with foetal HLA‐C2 may contribute to the risk of type 1 diabetes among Han Chinese children.
Incisional negative pressure wound therapy in reconstructive surgery of poststernotomy mediastinitis
Authors: Rashed Aref , Frenyo Magdolna , Gombocz Karoly , Szabados Sandor , Alotti Nasri 
Published: March 2016

AbstractThe efficacy of negative pressure wound therapy in the treatment of poststernotomy mediastinitis has been revealed in many reports. The present retrospective observational study examined the efficacy of incisional negative pressure wound therapy in the reconstructive surgery of poststernotomy mediastinitis. We retrospectively examined 1034 consecutive patients, who underwent median sternotomy in the period between October 2013 and September 2015. Mediastinitis developed in 21 patients (2%), who subsequently underwent surgical reconstruction. We applied incisional negative pressure wound therapy (iNPWT) after primary closure of the wound over redon drains in ten patients (iNPWT + redon group). In 11 patients, only redons were used (redons only group). We observed the time between the introduction and removal of redon drains, hospital stay until final wound closure and the rate of failure of treatment. Failure of treatment is defined as the need for further surgical reconstruction. In the iNPWT + redon group, the duration of redon drainage therapy was 6·9 ± 5·2 days versus 13·36 ± 11·58 in the redons only group. Hospital stay was 11·4 ± 8·6 versus 101·64 ± 89·2, and failure of treatment was 10% versus 45·5%, respectively. The primary results of this study appear to support the beneficial effect of iNPWT after radical wound reconstruction.
Quantitative analysis of short‐ and long‐distance racing performance in young and adult horses and association analysis with functional candidate genes in Spanish Trotter horses
Authors: Negro Rama S. , Valera M. , Membrillo A. , Gómez M.D. , Solé M. , Menendez‐Buxadera A. , Anaya G. , Molina A. 
Published: March 2016

SummaryThe association of five candidate genes with sporting performance in young and adult Spanish Trotter horses (STHs) was performed according to a previous selection based on quantitative analysis of the trait time per kilometre (TPK). A total of 334 516 records of TPK from 5958 STHs were used to estimate the estimated breeding values (EBVs) at different age groups (young and adults horses) throughout the range of distances (1600–2700 m) using a bicharacter random regression model. The heritability estimated by distance ranged from 0.16 to 0.40, with a different range for the two age groups. Considering the animals with the best and the worst deregressed EBV, 321 STHs were selected for SNP genotyping in MSTN, COX4I2, PDK4, DMRT3 and CKM genes. An association analysis based on ridge and logistic regression revealed that the young trotters with genotype GG in PDK4 (p < 0.05) and AA of DMRT3 (p < 0.001) SNPs show the best potential in short‐distance races, while those carrying the genotype AA in DMRT3 (p < 0.001) and CC in CKM (p < 0.05) genes seem to be the best in long‐distance races. Adult trotters with genotype AA in DMRT3 also display greater speed (p < 0.05) and endurance (p < 0.001).
The Differential Impact of Tourette's Syndrome and Comorbid Diagnosis on the Quality of Life and Functioning of Diagnosed Children and Adolescents
Authors: O'Hare Deirdre , Helmes Edward , Reece John , Eapen Valsamma , McBain Kerry 
Published: March 2016

PROBLEMTourette's syndrome (TS) is a neuropsychiatric disorder associated with adverse outcomes. High rates of comorbidity (80–90%) complicate presentation, yet the relationship among TS, common comorbid diagnoses, and adversity is not well understood. This research investigated the impact of comorbidity, and the discrete effects of common comorbid diagnoses, on quality of life (QoL) and functioning of youth with TS.METHODSA community sample of parents of youth with TS (n = 86) participated in this survey‐based study. Differences in QoL (Pediatric Quality of Life Inventory) and rates of psychological, behavioral, and social difficulties (Strength and Difficulties Questionnaire) reported for youth with or without comorbid disorder were determined, in addition to outcomes associated with individual disorders.FINDINGSParametric and nonparametric analyses revealed strong associations between comorbidity and decreased global QoL, impaired emotional and school functioning, and increased emotional symptomatology (p < .001). The impact of individual comorbid disorders was restricted and disorder specific, and TS was uniquely associated with impaired social functioning and peer relationship problems.CONCLUSIONSUnderstanding the risks associated with TS, particularly to psychosocial well‐being, and the specific risks accompanying individual comorbid disorders, may improve assessment, prioritization of treatment goals, and interventions targeting the individual, multidimensional needs of youth with TS.
Focus on Teen Men: Evaluating the Effectiveness of the Wise Guys Program
Authors: Herrman Judith W. , Moore Christopher , Rahmer Brian 
Published: March 2016

PROBLEMMany interventions designed to promote safe sexual behaviors in teens focus on young women. Wise Guys is one curricular intervention designed to foster safe sexual practices in young men. This study assessed knowledge, attitude, and behavioral changes as the result of Wise Guys.METHODSThis pre/posttest descriptive study measured changes in knowledge, attitudes, and sexual behaviors in 159 young men.FINDINGSThis study detected limited knowledge and attitude changes but yielded statistically significant differences in safe sexual behaviors and likelihood to talk with parents or guardians about sexuality and dating.CONCLUSIONSThis study revealed important benefits of Wise Guys and proposed future mixed methods research to ensure that authentic teen voices inform programing. Nurses working with adolescents may find this information valuable as they address sexual health issues in their work.
Twenty years of enamel matrix derivative: the past, the present and the future
Authors: Miron Richard J. , Sculean Anton , Cochran David L. , Froum Stuart , Zucchelli Giovanni , Nemcovsky Carlos , Donos Nikos , Lyngstadaas Staale Petter , Deschner James , Dard Michel , Stavropoulos Andreas , Zhang Yufeng , Trombelli Leonardo , Kasaj Adrian , Shirakata Yoshinori , Cortellini Pierpaolo , Tonetti Maurizio , Rasperini Giulio , Jepsen Søren , Bosshardt Dieter D. 
Published: March 2016

AbstractBacgroundOn June 5th, 2015 at Europerio 8, a group of leading experts were gathered to discuss what has now been 20 years of documented evidence supporting the clinical use of enamel matrix derivative (EMD). Original experiments led by Lars Hammarström demonstrated that enamel matrix proteins could serve as key regenerative proteins capable of promoting periodontal regeneration including new cementum, with functionally oriented inserting new periodontal ligament fibres, and new alveolar bone formation. This pioneering work and vision by Lars Hammarström has paved the way to an enormous amount of publications related to its biological basis and clinical use. Twenty years later, it is clear that all these studies have greatly contributed to our understanding of how biologics can act as mediators for periodontal regeneration and have provided additional clinical means to support tissue regeneration of the periodontium.AimsThis review article aims to: (1) provide the biological background necessary to understand the rational for the use of EMD for periodontal regeneration, (2) present animal and human histological evidence of periodontal regeneration following EMD application, (3) provide clinically relevant indications for the use of EMD and (4) discuss future avenues of research including key early findings leading to the development of Osteogain, a new carrier system for EMD specifically developed with better protein adsorption to bone grafting materials.
Longitudinal quantification of the gingival crevicular fluid proteome during progression from gingivitis to periodontitis in a canine model
Authors: Davis Ian J. , Jones Andrew W. , Creese Andrew J. , Staunton Ruth , Atwal Jujhar , Chapple Iain L. C. , Harris Stephen , Grant Melissa M. 
Published: March 2016

AbstractAimInflammatory periodontal disease is widespread in dogs. This study evaluated site‐specific changes in the canine gingival crevicular fluid (GCF) proteome during longitudinal progression from very mild gingivitis to mild periodontitis. Periodontitis diagnosis in dogs requires general anaesthesia with associated risks and costs; our ultimate aim was to develop a periodontitis diagnostic for application in conscious dogs. The objective of this work was to identify potential biomarkers of periodontal disease progression in dogs.Material and MethodsGingival crevicular fluid was sampled from a total of 10 teeth in eight dogs at three different stages of health/disease and samples prepared for quantitative mass spectrometry (data available via ProteomeXchange; identifier PXD003337). A univariate mixed model analysis determined significantly altered proteins between health states and six were evaluated by ELISA.ResultsFour hundred and six proteins were identified with 84 present in all samples. The prevalence of 40 proteins was found to be significantly changed in periodontitis relative to gingivitis. ELISA measurements confirmed that haptoglobin was significantly increased.ConclusionsThis study demonstrates for the first time that proteins detected by mass spectrometry have potential to identify novel biomarkers for canine periodontal disease. Further work is required to validate additional biomarkers for a periodontitis diagnostic.
Contribution of the distal small intestine to metabolic improvement after bariatric/metabolic surgery: Lessons from ileal transposition surgery
Authors: Oh Tae Jung , Ahn Chang Ho , Cho Young Min 
Published: March 2016

AbstractRoux‐en Y gastric bypass is a highly effective bariatric/metabolic surgical procedure that can induce robust weight loss and even remission of type 2 diabetes. One of the characteristic consequences of Roux‐en Y gastric bypass is the expedited nutrient delivery to the distal small intestine, where L‐cells are abundant and bile acid reabsorption occurs. To examine the role of the distal small intestine in isolation from other components of Roux‐en Y gastric bypass, the ileal transposition (IT) surgery has been used in various rat models. IT relocates the distal ileal segment to the upper jejunum distal to the ligament of Treitz without any other alterations in the gastrointestinal anatomy. Therefore, IT exposes the distal ileal tissue to ingested nutrients after a meal faster than the normal condition. Although there is some inconsistency in the effect of IT according to different types of rat models and different types of surgical protocols, IT typically improved glucose tolerance, increased insulin sensitivity and induced weight loss, and the findings were more prominent in obese diabetic rats. Suggested mechanisms for the metabolic improvements after IT include increased L‐cell secretion (e.g., glucagon‐like peptides and peptide YY), altered bile acid metabolism, altered host–microbial interaction, attenuated metabolic endotoxemia and many others. Based on the effect of IT, we can conclude that the contribution of the distal small intestine to the metabolic benefits of bariatric/metabolic surgery is quite considerable. By unveiling the mechanism of action of IT, we might revolutionize the treatment for obesity and type 2 diabetes.