bluuebunny/crossref_metadata_2025_split huggingface dataset:
O tabu da relação do lobby e políticas públicas no Brasil
Authors: Santano Ana Claudia , De Miranda Netto Fernando Gama , Blanchet Luiz Alberto 
Published: March 2017

Tema pouco estudado na literatura jurídica pátria, a pesquisa orienta-se pela possibilidade de o lobby trazer alguma contribuição para o desenvolvimento de políticas públicas no Brasil. Em tempos de desconfiança e de grande pressão exercidas sobre os poderes Executivo, Legislativo e Judiciário, torna-se importante analisar figuras marginalizadas e alvo de tabu no sistema, como os grupos de interesse, os grupos de pressão e o lobby. Neste sentido, fazendo uso do método bibliográfico, pretende-se estudar a relação existente entre esses fenômenos, bem como a outros aspectos que a eles estão vinculados. O trabalho finda por apresentar o lobby como um verdadeiro canal de comunicação entre as diversas esferas da organização política, ensejando a participação dos cidadãos em grupo das decisões do país, o que pode favorecer a transparência e até mesmo ao combate à corrupção.
Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52
Authors: Joshi Jugal Bharat , Patel Divya , Morton Derrick J. , Sharma Pankaj , Zou Jin , Hewa Bostanthirige Dhanushka , Gorantla Yamini , Nagappan Peri , Komaragiri Shravan Kumar , Sivils Jeffrey C. , Xie Huan , Palaniappan Ravi , Wang Guangdi , Cox Marc B. , Chaudhary Jaideep 
Published: March 2017

Castration‐resistant prostate cancer (CRPC) is the emergence of prostate cancer cells that have adapted to the androgen‐depleted environment of the prostate. In recent years, targeting multiple chaperones and co‐chaperones (e.g., Hsp27, FKBP52) that promote androgen receptor (AR) signaling and/or novel AR regulatory mechanisms have emerged as promising alternative treatments for CRPC. We have shown that inactivation of inhibitor of differentiation 4 (ID4), a dominant‐negative helix loop helix protein, promotes de novo steroidogenesis and CRPC with a gene expression signature that resembles constitutive AR activity in castrated mice. In this study, we investigated the underlying mechanism through which loss of ID4 potentiates AR signaling. Proteomic analysis between prostate cancer cell line LNCaP (L+ns) and LNCaP lacking ID4 (L(−)ID4) revealed elevated levels of Hsp27 and FKBP52, suggesting a role for these AR‐associated co‐chaperones in promoting constitutively active AR signaling in L(−)ID4 cells. Interestingly, protein interaction studies demonstrated a direct interaction between ID4 and the 52‐kDa FK506‐binding protein (FKBP52) in vitro, but not with AR. An increase in FKBP52‐dependent AR transcriptional activity was observed in L(−)ID4 cells. Moreover, pharmacological inhibition of FKBP52‐AR signaling, by treatment with MJC13, attenuated the tumor growth, weight, and volume in L(−)ID4 xenografts. Together, our results demonstrate that ID4 selectively regulates AR activity through direct interaction with FKBP52, and its loss, promotes CRPC through FKBP52‐mediated AR signaling.
The role of mantle‐derived magmas in the isotopic evolution of Yellowstone's magmatic system
Authors: Stelten Mark E. , Cooper Kari M. , Wimpenny Josh B. , Vazquez Jorge A. , Yin Qing‐Zhu 
Published: March 2017

AbstractInjection of mantle‐derived magmas into the Earth's crust provides the heat necessary to develop and maintain large silicic magmatic systems. However, the role of mantle‐derived magmas in controlling the compositional evolution of large silicic systems remains poorly understood. Here we examine the role of mantle‐derived magmas in the postcaldera magmatic system at Yellowstone Plateau, the youngest magmatism associated with the Yellowstone hotspot. Using microbeam techniques, we characterize the age and Hf isotope composition of single zircon crystals hosted in rhyolites from the most recent eruptive episode at Yellowstone Plateau, which produced the Central Plateau Member rhyolites. We place these zircon data into context by comparing them to new solution Hf isotope data for the Central Plateau Member glasses, Yellowstone basalts, and potential local crustal sources. Zircons in the Central Plateau Member rhyolites record a wide range of Hf isotope compositions relative to their host melts and extend from values similar to previously erupted Yellowstone rhyolites to values similar to Yellowstone basalts. Most zircons (∼90%) are in isotopic equilibrium with their host melt, but a significant proportion show εHf values higher than their host melt, thus providing the direct evidence that silicic derivatives of mantle‐derived basalts have recharged Yellowstone's magmatic system. Mixing models confirm that the isotopic characteristics of the youngest Yellowstone rhyolites can be explained by recharge of Yellowstone's magma reservoir with silicic derivatives of underplating, mantle‐derived basalts (∼5–10% material added by mass). This process helps drive the long‐term isotopic evolution of Yellowstone's magmatic system.
Petrogenesis of Early Cretaceous basaltic lavas from the North China Craton: Implications for cratonic destruction
Authors: Qian Sheng‐Ping , Ren Zhong‐Yuan , Richard Wysoczanski , Zhang Le , Zhang Yin‐Hui , Hong Lu‐Bing , Ding Xiang‐Li , Wu Ya‐Dong 
Published: March 2017

AbstractThe North China Craton (NCC) is believed to be the best example of cratonic destruction. However, the processes leading to cratonic destruction remain unclear, largely due to a lack of knowledge of the nature of the Mesozoic NCC lithospheric mantle. Here we report new petrological and geochemical data for Early Cretaceous NCC basalts, which provide insights into the nature of the underlying lithospheric mantle. The Early Cretaceous basalts (all tholeiites) show a limited variation in geochemical composition. In contrast, olivine‐hosted melt inclusions from these basalts display a wide range in compositional variation and include both alkalic and tholeiitic basaltic compositions. This result provides the direct evidence of the contribution of silica‐undersaturated alkali basaltic melts in the petrogenesis of the Early Cretaceous NCC basalts. In addition, the compositions of olivine phenocrysts and reconstructed primary melts indicate that the Early Cretaceous basalts are derived from a mixed peridotite and refertilized peridotite source. The Pb isotopic compositions of melt inclusions in high fugacity of oxygen (fo) olivines combined with trace element characteristics of these basalts reveal that heterogeneous lithospheric mantle sources for Early Cretaceous basalts were metasomatized by carbonate‐bearing eclogite‐derived melts. The Pb isotopic variations of the melt inclusions and clinopyroxene and plagioclase phenocrysts demonstrate that the mantle‐derived magmas were variably contaminated by lower continental crust. We propose that multiple subduction events during the Phanerozoic, combined with mantle‐plume activity, likely play a vital role in the generation of the Early Cretaceous voluminous magmatism and cratonic destruction.
Temperature flux carried by individual eddies across 47°N in the Atlantic Ocean
Authors: Müller Vasco , Kieke Dagmar , Myers Paul G. , Pennelly Clark , Mertens Christian 
Published: March 2017

AbstractSurface geostrophic velocity fields derived from satellite altimetry between January 1993 and April 2014 are used to detect and investigate eddies in the North Atlantic between 40°N–55°N and 60°W–10°W. Focus is on a zonal section along 47°N, roughly at the boundary between the subpolar and the subtropical gyres. Sea surface temperature data are used to quantify the temperature anomalies associated with eddies and the respective surface temperature fluxes related to these eddies. Identified eddy pathways across 47°N are related to the mean background velocity from full‐depth ship observations carried out on 11 cruises between 2003 and 2014. The analysis is repeated in two model simulations with 1/4° and 1/12° horizontal resolution, respectively, for the period 2002–2013. The analysis reveals almost 37,000 altimeter‐derived eddies with a lifetime longer than 1 week in the area. The highest number of eddies is found along the pathway of the North Atlantic Current, roughly following the 4000 m isobath, and on the Grand Banks of Newfoundland. Time series of temperature fluxes by eddies crossing 47°N reveal that single isolated eddies with large SST signatures contribute ∼25% to the surface temperature flux. Relating the observed eddies to the observed top‐to‐bottom velocity distribution at 47°N points to the existence of eddy pathways across 47°. The highest‐temperature fluxes are linked to the fastest and most pronounced current branches in the western Newfoundland Basin. While there are fewer eddies in both model simulations, the key findings are consistent between the observations and the two model simulations.
Frequency content of sea surface height variability from internal gravity waves to mesoscale eddies
Authors: Savage Anna C. , Arbic Brian K. , Richman James G. , Shriver Jay F. , Alford Matthew H. , Buijsman Maarten C. , Thomas Farrar J. , Sharma Hari , Voet Gunnar , Wallcraft Alan J. , Zamudio Luis 
Published: March 2017

AbstractHigh horizontal‐resolution (
and
) 41‐layer global simulations of the HYbrid Coordinate Ocean Model (HYCOM), forced by both atmospheric fields and the astronomical tidal potential, are used to construct global maps of sea surface height (SSH) variability. The HYCOM output is separated into steric and nonsteric and into subtidal, diurnal, semidiurnal, and supertidal frequency bands. The model SSH output is compared to two data sets that offer some geographical coverage and that also cover a wide range of frequencies—a set of 351 tide gauges that measure full SSH and a set of 14 in situ vertical profilers from which steric SSH can be calculated. Three of the global maps are of interest in planning for the upcoming Surface Water and Ocean Topography (SWOT) two‐dimensional swath altimeter mission: (1) maps of the total and (2) nonstationary internal tidal signal (the latter calculated after removing the stationary internal tidal signal via harmonic analysis), with an average variance of
and
, respectively, for the semidiurnal band, and (3) a map of the steric supertidal contributions, which are dominated by the internal gravity wave continuum, with an average variance of
. Stationary internal tides (which are predictable), nonstationary internal tides (which will be harder to predict), and nontidal internal gravity waves (which will be very difficult to predict) may all be important sources of high‐frequency “noise” that could mask lower frequency phenomena in SSH measurements made by the SWOT mission.
Cultivating the ‘In‐Between’: Humanising the Modern Healthcare Experience
Authors: Montgomery Terry 
Published: March 2017

Corridors and waiting rooms are as important to the patient experience as clinical spaces. Yet in modernist hospitals they tend to be isolating, soul‐destroying places to be. Since the 1970s, Toronto‐based Montgomery Sisam Architects have been redressing the balance, enhancing patient wellbeing and restoring a connection to the great outdoors by focusing on the porch, the gallery and the courtyard.Terry Montgomery, one of the firm's cofounders, here cites their inspirations, from traditional towns and centuries‐old hospitals to modern urban theorists, and presents some of their recent buildings.
Phosphine‐Mediated Dimerization of Conjugated Ene‐Yne Ketones: Stereoselective Construction of Dihydrobenzofurans
Authors: Zhu Cheng‐Zhi , Sun Yao‐Liang , Wei Yin , Shi Min 
Published: March 2017

AbstractA new strategy for the phosphine‐mediated dimerization of conjugated ene‐yne ketones to produce functionalized dihydrobenzofurans has been developed, affording diversified 4,5‐dihydrobenzofurans in moderate to excellent yields with high diastereoselectivities under mild conditions. This new synthetic method can tolerate a variety of functional groups and can be performed on a gram scale and in an asymmetric variant using the chiral phosphine Xyl‐BINAP to give the desired products with up to 94% ee.magnified image
A case of circumferential type A aortic dissection with intimal intussusception diagnosed using repeat transthoracic echocardiography examination
Authors: Yamagishi Toshinobu , Kashiura Masahiro , Nakata Kazuya , Miyazaki Kazuki , Yukawa Takahiro , Tanabe Takahiro , Sugiyama Kazuhiro , Akashi Akiko , Hamabe Yuichi 
Published: March 2017

CaseSometimes it is difficult to diagnose circumferential aortic dissection with enhanced computed tomography alone. A 58‐year‐old woman presented with sudden‐onset chest discomfort and loss of consciousness. Transthoracic echocardiogram showed mild aortic regurgitation. Enhanced computed tomography scans showed no obvious intimal tear or flap at the proximal ascending aorta, but an intimal flap was observed from the aortic arch to both common iliac arteries. Stanford type B dissection was tentatively diagnosed. Repeat detailed transthoracic echocardiography examination showed an intimal tear and flap at the ascending aorta; prolapse into the left ventricle caused severe aortic regurgitation. Type A aortic dissection was definitively diagnosed; emergent operation showed a circumferential intimal tear originating from the ascending aorta.OutcomeThe ascending aorta was replaced; aortic regurgitation disappeared. The patient was discharged in a good condition 58 days postoperatively.ConclusionDynamic evaluations with transthoracic echocardiography should be carried out to diagnose circumferential aortic dissection.
Transient dynamics of a one‐dimensional Holstein polaron under the influence of an external electric field
Authors: Huang Zhongkai , Chen Lipeng , Zhou Nengji , Zhao Yang 
Published: March 2017

Following the Dirac‐Frenkel time‐dependent variational principle, transient dynamics of a one‐dimensional Holstein polaron with diagonal and off‐diagonal exciton‐phonon coupling in an external electric field is studied by employing the multi‐D2 Ansatz, also known as a superposition of the usual Davydov D2 trial states. Resultant polaron dynamics has significantly enhanced accuracy, and is in perfect agreement with that derived from the hierarchy equations of motion method. Starting from an initial broad wave packet, the exciton undergoes typical Bloch oscillations. Adding weak exciton‐phonon coupling leads to a broadened exciton wave packet and a reduced current amplitude. Using a narrow wave packet as the initial state, the bare exciton oscillates in a symmetric breathing mode, but the symmetry is easily broken by weak coupling to phonons, resulting in a non‐zero exciton current. For both scenarios, temporal periodicity is unchanged by exciton‐phonon coupling. In particular, at variance with the case of an infinite linear chain, no steady state is found in a finite‐sized ring within the anti‐adiabatic regime. For strong diagonal coupling, the multi‐ Anstaz is found to be highly accurate, and the phonon confinement gives rise to exciton localization and decay of the Bloch oscillations.
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Preparation of antibacterial cellulose with s‐triazine‐based quaternarized N‐halamine
Authors: Jiang Zhiming , Qiao Mingyu , Ren Xuehong , Zhu Ping , Huang Tung‐Shi 
Published: March 2017

ABSTRACTTo reduce the neutral salt used in the textile finishing with s‐triazine derivatives, a novel s‐triazine‐based quaternarized N‐halamine precursor was synthesized by two simple steps and characterized by H‐NMR and FT‐IR. This compound can be effectively coated onto cellulose by nucleophilic substitution process without neutral salt. The treated cellulose was rendered with powerful biocidal efficacy after transferring to an N‐halamine structure by exposing to dilute sodium hypochlorite solution through the synergistic antimicrobial effect quaternary ammonium salt and N‐halamine. The chlorinated samples could inactivate 6‐logs of Staphylococcus aureus and Escherichia coli O157:H7 within 1 min and 5 min, respectively. In addition, about 50% of oxidant chlorine remained after 50 washing cycles and 30 days storage, and all of the lost active chlorines in the N‐halamine molecules recovered after exposing to bleach solution. With these advantages, the as‐prepared antimicrobial fabrics will have potential application, especially in the medical and healthcare textiles. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 44998.
Ausstanzmodell mit Rissreibung für Verbunddübelleisten im gerissenen Beton
Authors: Claßen Martin , Hegger Josef 
Published: March 2017

AbstractDie Schubtragfähigkeit von Verbunddübelleisten mit Ausstanzversagen wird durch Querrisse im Betongurt vermindert. Experimentelle Untersuchungen zeigen, dass Querrisse als Begrenzungen des Betonausstanzkegels wirken, an denen eine Kraftübertragung lediglich durch Rissreibung erfolgt. In den bisherigen Bemessungsansätzen für Verbunddübelleisten wird der Einfluss von Rissbildung im Beton nicht berücksichtigt. Hieraus kann ein Sicherheitsdefizit in der Bemessung von Verbundträgern mit Verbunddübelleisten resultieren, falls der Betongurt vollständig oder bereichsweise aufreißt. Im vorliegenden Beitrag wird daher ein mechanisch basierter Modellansatz für das Ausstanzen von Verbunddübelleisten im gerissenen und ungerissenen Beton hergeleitet, der die Übertragung von Schubspannungen durch Rissverzahnung berücksichtigt. Mit dem Modell lassen sich die vorhandenen Versuche mit guter Genauigkeit nachrechnen. Das Ausstanzmodell für den gerissenen und ungerissenen Beton wird anhand einer Versuchsdatenbank validiert und auf das Bemessungsniveau überführt. Das entwickelte Modell lässt sich auf das Tragverhalten von Befestigungen (Kopfbolzen und Hinterschnittdübel) im gerissenen Ankergrund übertragen. Alle vorgestellten Untersuchungen wurden im Rahmen von [1] durchgeführt und sind hierin ausführlich beschrieben.
Der armierte Beton im Geschossbau
Authors: Polónyi Stefan 
Published: March 2017

AbstractDer französische Gärtner Joseph Monier hat seine aus Zementmörtel hergestellten Pflanzkübel mit Drahtringen armiert. Seiner Idee wurde 1867 das Patent erteilt. Die Bauingenieure waren bemüht, diese Erfindung auf ihre Tragkonstruktionen anzuwenden. Für die rechnerische Erfassung des bewehrten Balkens standen drei Analogtragverhalten zur Verfügung: der Bogen, das Hängewerk und das Fachwerk. Da man sich gerade unter der „Herrschaft” der Fachwerkstatik befand, entschied man sich für das Fachwerk, womit die Eigenschaften des Betons im Wesentlichen außer Acht blieben. Aus Rundstäben wurden Bewehrungskörbe gebunden und diese einbetoniert.Im Gegensatz zu seiner großen Druckfestigkeit besitzt Beton nur eine geringe Zugfestigkeit. Das bedeutet, dass Bewehrungsstäbe dort eingelegt werden müssen, wo der Beton die während der vorgesehenen Nutzung auftretende Zugbeanspruchung nicht aufnehmen kann. Im Folgenden wird erörtert, wo und wie der Beton eines mehrgeschossigen Hauses bewehrt bzw. nicht bewehrt werden soll [1].
Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non‐diphosphate Inhibitors
Authors: O'Dowd Bing , Williams Sarah , Wang Hongxin , No Joo Hwan , Rao Guodong , Wang Weixue , McCammon J. Andrew , Cramer Stephen P. , Oldfield Eric 
Published: March 2017

AbstractIsoprenoid biosynthesis is an important area for anti‐infective drug development. One isoprenoid target is (E)‐1‐hydroxy‐2‐methyl‐but‐2‐enyl 4‐diphosphate (HMBPP) reductase (IspH), which forms isopentenyl diphosphate and dimethylallyl diphosphate from HMBPP in a 2H+/2e− reduction. IspH contains a 4 Fe−4 S cluster, and in this work, we first investigated how small molecules bound to the cluster by using HYSCORE and NRVS spectroscopies. The results of these, as well as other structural and spectroscopic investigations, led to the conclusion that, in most cases, ligands bound to IspH 4 Fe−4 S clusters by η1 coordination, forming tetrahedral geometries at the unique fourth Fe, ligand side chains preventing further ligand (e.g., H2O, O2) binding. Based on these ideas, we used in silico methods to find drug‐like inhibitors that might occupy the HMBPP substrate binding pocket and bind to Fe, leading to the discovery of a barbituric acid analogue with a Ki value of ≈500 nm against Pseudomonas aeruginosa IspH.
Delayed right ventricular defibrillation lead perforation presenting as cardiac tamponade and treated surgically
Authors: Noguchi Masahiko , Nakai Toshiko , Kawano Yuji , Shibayama Kentaro , Obunai Kotaro , Tabata Minoru , Watanabe Hiroyuki 
Published: March 2017

Key Clinical MessageRight ventricular perforation leading to cardiac tamponade can occur during the chronic phase after cardiac device implantation. Physicians who manage the pacemaker clinic must be alert to the wide range of symptoms and signs that can accompany delayed right ventricular perforation. Surgical rather than percutaneous lead extraction may be prudent.
Persistence of a t(11;14)‐positive clone in a patient with mantle cell lymphoma for 20 years
Authors: Otsuka Yasuyuki , Nishikori Momoko , Kitano Toshiyuki , Oka Tomomi , Ishikawa Takayuki , Haga Hironori , Takaori‐Kondo Akifumi 
Published: March 2017

Key Clinical MessageWe report here a patient with extremely indolent mantle cell lymphoma (MCL) who had progressed and required immunochemotherapy 20 years after diagnostic splenectomy. Non‐nodal, indolent MCL patients may progress after such an extraordinary long indolent phase, and we recommend lifelong follow up for such cases.
Adrenal venous sampling in a patient with left inferior vena cava
Authors: Fujii Yuichi , Ueda Tomohiro , Uchimura Yuko , Teragawa Hiroki 
Published: March 2017

Key Clinical MessageAdrenal venous sampling (AVS), although difficult, is recommended for patients with primary aldosteronism (PA) to diagnose the subtype. Recognizing anatomical variation is key to a successful AVS. We report on a patient with PA and left inferior vena cava (IVC) whose left adrenal vein drained directly into the IVC.
Innovative Carbon Dioxide‐Capturing Organic Solvent: Reaction Mechanism and Kinetics
Authors: Orhan Ozge Yuksel , Tankal Hilal , Kayi Hakan , Alper Erdogan 
Published: March 2017

AbstractThe reaction rates of CO2 with an innovative CO2‐capturing organic solvent (CO2COS), consisting of blends of 2‐tert‐butyl‐1,1,3,3‐tetramethylguanidine (BTMG) and 1‐propanol, were obtained as function of BTMG concentration and temperature. A stopped‐flow apparatus with conductivity detection was used. The reaction was modeled by means of a modified termolecular reaction mechanism which resulted in a second‐order rate constant, and activation energies were calculated for a defined temperature range. Quantum chemical calculations at the B3LYP/6‐31G(d) level also produced the activation energy of this reaction system which strongly supports the experimental findings.
From Moldy Orange Waste to Natural Reductant and Catalyst Support: Active Palladium/Biomass‐Derived Carbonaceous Hybrids for Promoted Methanol Electro‐Oxidation
Authors: Da Zulin , Niu Xiangheng , Li Xin , Zhang Wenchi , He Yanfang , Pan Jianming , Qiu Fengxian , Yan Yongsheng 
Published: March 2017

AbstractFacile, green, and low‐cost synthesis of advanced electrocatalysts is widely considered an urgent issue and a current challenge for clean energy conversion. Here, we report the green fabrication of a new Pd/C(OJ) hybrid, using orange juice (OJ) simultaneously as a natural reductant and a support precursor, for the methanol oxidation reaction (MOR) in alkaline media. The juice extracted from discarded moldy oranges is capable of reducing the [PdCl4]2− species into metallic Pd through a simple hydrothermal reaction, and then becomes the nitrogen‐doped carbonaceous support after pyrolysis for active catalyst loading. In the synthesized Pd/C(OJ) hybrid, Pd nanoparticles with a mean size of 7.3 nm are highly dispersed throughout the support, providing a larger electrochemically active surface area than commercial Pd/C. As a result, the Pd/C(OJ) electrocatalyst exhibits 1.78 times the mass activity of the latter for the MOR. The preferable performance durability of Pd/C(OJ) is also verified by using cyclic voltammetry and simulative startup−shutdown measurements.