bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetics in type 1 diabetes:TNFagene promoter methylation status in Chilean patients with type 1 diabetes mellitus
Authors: Arroyo-Jousse Viviana , Garcia-Diaz Diego F. , Codner Ethel , Pérez-Bravo Francisco 
Published: November 2016

AbstractTNF-αis a pro-inflammatory cytokine that is involved in type 1 diabetes (T1D) pathogenesis. TheTNFagene is subject of epigenetic regulation in which folate and homocysteine are important molecules because they participate in the methionine cycle where the most important methyl group donor (S-adenosylmethionine) is formed. We investigated whetherTNFagene promoter methylation status in T1D patients was related to blood folate, homocysteine and TNF-αin a transversal case–control study. We studied T1D patients (n25, mean=13·7 years) and healthy control subjects (n25, mean=31·1 years), without T1D and/or other autoimmune diseases or direct family history of these diseases. A blood sample was obtained for determination of serum folate, plasma homocysteine and TNF-αconcentrations. Whole blood was used for the extraction of DNA to determine the percentage of methylation by real-time PCR and melting-curve analysis. Results are expressed as means and standard deviations for parametric variables and as median (interquartile range) for non-parametric variables. T1D patients showed a higherTNFagene promoter methylation (39·2 (sd19·5) %) when compared with control subjects (25·4 (sd13·7) %) (P=0·008).TNFagene promoter methylation was positively associated only with homocysteine levels in T1D patients (r0·55,P=0·007), but not in control subjects (r−0·122,P=0·872). To our knowledge, this is the first work that reports the methylation status of theTNFagene promoter and its relationship with homocysteine metabolism in Chilean T1D patients without disease complications.
Fāṭimid gardens: archaeological and historical perspectives
Authors: Pradines Stephane , Khan Sher Rahmat 
Published: November 2016

AbstractThis article is the first systematic investigation on the location, layout, design and functions of Fāṭimid gardens. Our study is based on primary sources and focuses on different elements of the recreational and ceremonial functions of gardens. Very little is known about the layout of the royal Fāṭimid gardens because no garden has survived or been excavated so far as we are aware. However, we collected physical insights on the layout and shape of these Fāṭimid gardens through different archaeological excavations in Cairo and outside of Egypt, including our recent discoveries and the garden that we found in Darrāsa.
Emerging preoccupations, developing lexicon
Authors: Poole Brian 
Published: November 2016

‘There is a very close link between the life of a society and the lexicon of the language spoken by it.’ (Wierzbicka, 1997: 1).A few decades ago it probably seemed, to proficient English language users, that if one was ‘active’ that would be sufficient to win plaudits from one's boss and to impress one's friends. After all, being active implies, amongst other things, that one's behaviour is ‘characterized by busy or lively activity’ (Oxford Dictionaries online). However, more recently it has begun to seem that activeness is not enough: one must be ‘proactive’. Cooley (2016) provides readers with ten ways in which they can be more proactive at work. The promotion of proactiveness (or should that be proactivity?) seems, at least on the evidence of this extract, to require a liberal sprinkling of exclamation marks
Epidemic host community contribution to mosquito-borne disease transmission: Ross River virus
Authors: KOOLHOF I. S. , CARVER S. 
Published: November 2016

SUMMARYMost vector-borne diseases infect multiple host species, but disentangling the relative importance of different host species to transmission can be complex. Here we study how host species’ abundance and competence (duration and titre of parasitaemia) influence host importance during epidemic scenarios. We evaluate this theory using Ross River virus (RRV, family Togaviridae, genus Alphavirus), a multi-host mosquito-borne disease with significant human health impacts across Australia and Papua New Guinea. We used host contribution models to find the importance of key hosts (possums, wallabies, kangaroos, horses, humans) in typical mammal communities around five Australian epidemic centres. We found humans and possums contributed most to epidemic RRV transmission, owing to their high abundances, generally followed by macropods. This supports humans as spillover hosts, and that human–mosquito and possum–mosquito transmission is predominant during epidemics. Sensitivity analyses indicate these findings to be robust across epidemic centres. We emphasize the importance of considering abundance and competence in identifying key hosts (during epidemics in this case), and that competence alone is inadequate. Knowledge of host importance in disease transmission may help to equip health agencies to bring about greater effectiveness of disease mitigation strategies.
Competing systems in Philadelphia phonology
Authors: Labov William , Fisher Sabriya , Gylfadottír Duna , Henderson Anita , Sneller Betsy 
Published: November 2016

AbstractThis is a study of the competition of linguistic systems within the speech community, tracing the opposition of distinct phonological configurations. Among younger Philadelphians oriented to higher education, the traditional short-a system is giving way to the nasal system, in which all prenasal vowels are tense. We present evidence that this shift occurs systematically in both the lax and tense allophones. The degree of conformity to each system is measured for 106 subjects by the Pillai statistic; community-wide patterns are revealed by regression modeling and bimodality diagrams. Adherence to the traditional system is greatest for White speakers who graduated from Catholic high schools, while the nasal system is strongest for graduates from elite schools with special admission requirements. African American students show no orientation to the traditional system, but parallel White students in the shift to the nasal system. The histories of students through the educational system show that the speaker's short-a system is largely determined during their middle and high school years, before entering college. Special admission interviews play a special role in this process, as brief speech events that strongly determine the person's linguistic environment for the years that follow.
ON THE TRAIL OF QUETZALCOATL/KUKULCAN: TRACING MYTHIC INTERACTION ROUTES AND NETWORKS IN THE MAYA LOWLANDS
Authors: Folan William J. , Bolles David D. , Ek Jerald D. 
Published: November 2016

AbstractThis paper examines ethnohistoric accounts and oral histories accumulated during the last 50 years concerning the movements of the mythical personage of Quetzalcoatl/Kukulcan (Kukul Can) and the role of these narratives in political ideologies between the Epiclassic and Postclassic periods. These narratives outline the movements of Quetzalcoatl/Kukulcan by way of terrestrial, celestial, and subterranean routes that connected pilgrimage centers across the Maya lowlands in the peninsula of Yucatan. Ethnographic and ethnohistoric data presented in this paper describe linkages between important political, economic, and ritual centers that had roots in pan-Mesoamerican social dynamics originating as early as the Terminal Classic or Epiclassic period. Links between cities included not just the physical intersite connections evidenced by causeways that are so prominent in the archaeological record but also intangible, mythical, and symbolic connections embodied in mythical histories of subterranean passageways and celestial umbilical cords. These accounts and oral histories highlight the importance of migration and founding events in the establishment of new cities during the major political, economic, and social reorganizations that took place after the end of the Late Classic period. As a whole, these linkages comprised a political infrastructure connecting a network of cities within the highly integrated and international Postclassic Mesoamerican world. The indigenous histories outlined in this paper complement archaeological data, reflecting an increase in internationalism, economic integration, and the spread of new religious movements beginning in the Terminal or Epiclassic periods across Mesoamerica.
HUMAN SACRIFICE AND DIVINE NOURISHMENT IN MESOAMERICA: THE ICONOGRAPHY OF CACAO ON THE PACIFIC COAST OF GUATEMALA
Authors: Chinchilla Mazariegos Oswaldo 
Published: November 2016

AbstractThis article explores the sacrificial symbolism of cacao (Theobromasp.) on the Pacific coast of Guatemala, manifest in the iconography of ceramic objects and stone sculptures from the Classic period, in textual references from the colonial period, and in contemporary ethnographic data from the southern highlands. The iconographic and textual metaphors contained in these sources linked cacao pods with dead warriors, captives, and sacrificial victims. As interpreted in this article, the harvest of cacao was equated with the acquisition of sacrificial victims, and both were conceived as precious sources of nourishment for the gods. Changes in artistic representations are discernible from Early Classic Teotihuacan-style censers to Early Postclassic Plumbate ceramic effigies. Cacao and other fruits from the Pacific coastal piedmont are still related to the symbolism of war and sacrifice in contemporary rituals from the Tz'utujil town of Santiago Atitlán. Data from southern Guatemala may be relevant to understand the sacrificial symbolism of cacao throughout Mesoamerica.
THE POLYCHROME CERAMICS OF TUTUTEPEC (YUCU DZAA), OAXACA, MEXICO: ICONOGRAPHY AND IDEOLOGY
Authors: Forde Jamie E. 
Published: November 2016

AbstractIn this article, I present the results of an analysis of codex-style polychrome ceramics recovered from excavations of commoner households at the Late Postclassic center of Tututepec (Yucu Dzaa), Oaxaca, Mexico. In employing a basic semiotic approach, I examine the images depicted on these materials to draw inferences regarding salient themes they expressed, and how these themes related to broader social discourse and political ideology. In short, I argue that the data suggest an articulation between the popular ideologies of commoners and ideals that were promoted by the site's ruling elites, a concordance that likely arose through dialogic social processes, rather than coercion or false consciousness. This state of affairs may have contributed to the success of the polity, which was the center of a powerful territorial empire at the time of Spanish contact.
FILTH AND HEALING IN YUCATAN: INTERPRETING IX HUN AHAU, A MAYA GODDESS
Authors: Knowlton Timothy W. 
Published: November 2016

AbstractThis paper analyzes the roles and attributes of the Maya goddess Ix Hun Ahau, the female manifestation of Hun Ahau that appears in theRitual of the Bacabs. This Colonial Yucatec text is our earliest surviving source for how Maya cosmology provided a framework for healing practices. Although the extant manuscript dates to the late eighteenth century, it is the culmination of centuries of interethnic interaction, including innovations emerging from the intellectual exchange that characterized Mesoamerica during the Late Postclassic period (ca. A.D. 1200–1500). The accoutrements and activities ascribed to this goddess in the incantations identify her as a Maya parallel to Tlazolteotl-Ixcuina, the Nahua goddess of weaving, sexuality, pollution, and its purification. Pollution concepts and purification practices that are otherwise peripheral in theRitual of the Bacabs are specifically related to Ix Hun Ahau, suggesting that early intellectual exchange between Mesoamerican peoples extended to medical cosmologies as well.
A SEVENTH-CENTURY INSCRIBED MINIATURE FLASK FROM COPAN FOUND AT TAZUMAL, EL SALVADOR
Authors: Card Jeb J. , Zender Marc 
Published: November 2016

AbstractLate Classic interaction between Copan and western El Salvador has been archaeologically recognized in prestige items, monumental influences, and the common use of Copador ceramics. An inscribed flask excavated in 1952 in the main pyramid at Tazumal, El Salvador provides historical evidence for these ties. The flask is dedicated as the property of K'ahk' Uti' Witz' K'awiil (Copan Ruler 12), a long-lived seventh-century ruler who presided over the expansion of Copan's influence far outside of the Copan valley. The flask is the only hieroglyphic text from El Salvador naming a recognizable individual or that can be dated to an absolute calendrical span, one of only a few miniature Classic Maya vessels tagged with an individual's name, and the only one naming anajaw(lord). The vessel's text, iconography, and context brings the political relationship between Copan and western El Salvador into sharper focus.
CASTING MAIZE SEEDS IN AN AYÖÖK COMMUNITY: AN APPROACH TO THE STUDY OF DIVINATION IN MESOAMERICA
Authors: Rojas Araceli 
Published: November 2016

AbstractRecent investigation among the Ayöök (Mixe) people of Oaxaca showed that the on-going use of a 260-day calendar complements the divinatory technique of casting maize seeds. This paper offers a detailed description of this mantic practice as a means to approach and better understand precolonial divinatory practices and the people who practiced them, such as thetonalopouhqueamong the Nahua. In particular, this new data will also serve to shed light on the use of the pictorial manuscripts that portray the 260-day calendar, such as the so-called Borgia Group Codices. Along these lines, historical and colonial accounts, origin narratives, visual culture, and the archaeology surrounding divination will also be re-examined. This article will show that, similar to the Ayöök contemporary daykeepers and diviners, those that lived in the past were also wise women and men who were specialized in managing the complicated system of symbolism surrounding prognostication and prescription set out over 260 days. Furthermore, they employed divination for medical purposes and aided people with afflictions, curing them of sickness.
Auditory Vigilance and Working Memory in Youth at Familial Risk for Schizophrenia or Affective Psychosis in the Harvard Adolescent Family High Risk Study
Authors: Seidman Larry J. , Pousada-Casal Andrea , Scala Silvia , Meyer Eric C. , Stone William S. , Thermenos Heidi W. , Molokotos Elena , Agnew-Blais Jessica , Tsuang Ming T. , Faraone Stephen V. 
Published: December 2016

AbstractBackground: The degree of overlap between schizophrenia (SCZ) and affective psychosis (AFF) has been a recurring question since Kraepelin’s subdivision of the major psychoses. Studying nonpsychotic relatives allows a comparison of disorder-associated phenotypes, without potential confounds that can obscure distinctive features of the disorder. Because attention and working memory have been proposed as potential endophenotypes for SCZ and AFF, we compared these cognitive features in individuals at familial high-risk (FHR) for the disorders. Methods: Young, unmedicated, first-degree relatives (ages, 13–25 years) at FHR-SCZ (n=41) and FHR-AFF (n=24) and community controls (CCs, n=54) were tested using attention and working memory versions of the Auditory Continuous Performance Test. To determine if schizotypal traits or current psychopathology accounted for cognitive deficits, we evaluated psychosis proneness using three Chapman Scales, Revised Physical Anhedonia, Perceptual Aberration, and Magical Ideation, and assessed psychopathology using the Hopkins Symptom Checklist -90 Revised. Results: Compared to controls, the FHR-AFF sample was significantly impaired in auditory vigilance, while the FHR-SCZ sample was significantly worse in working memory. Both FHR groups showed significantly higher levels of physical anhedonia and some psychopathological dimensions than controls. Adjusting for physical anhedonia, phobic anxiety, depression, psychoticism, and obsessive-compulsive symptoms eliminated the FHR-AFF vigilance effects but not the working memory deficits in FHR-SCZ. Conclusions: The working memory deficit in FHR-SZ was the more robust of the cognitive impairments after accounting for psychopathological confounds and is supported as an endophenotype. Examination of larger samples of people at familial risk for different psychoses remains necessary to confirm these findings and to clarify the role of vigilance in FHR-AFF. (JINS, 2016, 22, 1026–1037)
Earth analogues for past and future life on Mars: isolation of perchlorate resistant halophiles from Big Soda Lake
Authors: Matsubara Toshitaka , Fujishima Kosuke , Saltikov Chad W. , Nakamura Satoshi , Rothschild Lynn J. 
Published: November 2016

AbstractThe Martian regolith is known to contain a maximum of 0.5% (w/v) perchlorate (ClO4−) that is toxic for most living organisms. With such high concentrations of perchlorates on Mars, is there any possibility of life? Here, in order to search and identify potential organisms on Earth, which could survive the perchlorate levels on Mars, we have isolated four perchlorate resistant, halophilic/halotolerant bacterial species from Big Soda Lake (BSL) in Nevada, USA. The 16S ribosomal RNA sequences revealed that these halophiles belong to the genera Bacillus, Alkalibacillus and Halomonas. Growth curves were obtained using a saline medium with different concentrations of magnesium, sodium and/or calcium perchlorate salt to simulate the Martian eutectic brine water. All four species, BSL1-4, grew in high saline media in the presence of perchlorates. This is the first growth experiment using multiple perchlorate salts. BSL3 relative to Halomonas salifodinae showed high maximum growth (Optical Density) comparing with other isolates in the presence of 1% perchlorate salts. Also, BSL1 relative to Bacillus licheniformis survived in the presence of 5% Na-perchlorate, but growth was slower in the absence of Na-perchlorate. The results revealed that these new model microbes are capable of tolerating the hypothesized hypersaline and perchlorate-rich Martian subsurface water environment. Perchlorate-resistant halophile would serve as a new model to understand the biochemistry that may occur on Mars.
Realism, Idealism and the French Reception of Hanslick
Authors: Verzosa Noel 
Published: November 2016

When Charles Bannelier’s French translation of Hanslick’s Vom Musikalisch-Schönen was published in 1877, it elicited discussions among French musicians and critics that can seem puzzling from our twenty-first century vantage point. The French were almost entirely ambivalent to the issue of descriptive versus non-programmatic music and were perfectly comfortable disregarding this seemingly central point of contention in Hanslick’s treatise. French critics focused instead on issues that seem tangential to the main thrust of Vom Musikalisch-Schönen: German music education, the merits of philosophy versus philology, and so forth.The French reception of Hanslick becomes less puzzling, however, when we consider the conceptual framework within which French musical discourse operated in the late nineteenth century. By 1877, musical aesthetics and criticism in France were an extension of broader trends in French intellectual culture, in which a materialist, realist view of the world vied with a metaphysical, idealist conception of the divine. Between these two ideological poles lay a rich spectrum of ideas that had profound ramifications for music and art criticism. The degree to which works of art could be understood as products of historical circumstances, for example, or whether art embodied ineffable meanings resisting explanation, were questions whose answers depended on one’s position along this realist–idealist spectrum.In this article, I show how this tension between realism and idealism formed the conceptual framework for French critics’ readings of Hanslick’s Vom Musikalisch-Schönen. I survey writings by Théodule Ribot, Jules Combarieu, Camille Bellaigue and others to show how this network of texts, when placed alongside each other, was effectively a manifestation of the realist–idealist spectrum. By putting these writings in conversation with each other, this article brings to light the intellectual premises of French writings on music in the nineteenth century. Only by understanding these premises, I argue, can we make sense of the French reception of Hanslick.
Epigenetic programming of Dnmt3a mediated by AP2α is required for granting preadipocyte the ability to differentiate
Authors: Guo Wei , Chen Jiangnan , Yang Ying , Zhu Jianbei , Wu Jiarui 
Published: December 2016

AbstractAdipogenesis has an important role in regulating energy homeostasis in mammals. 3T3-L1 preadipocytes have been widely used as an in vitro model for analyzing the molecular mechanism of adipogenesis. Previous reports indicated that the stage of contact inhibition (CI), through which the proliferating cells exit from the cell cycle, was required for granting preadipocyte the ability to differentiate. While this kind of the granting mechanism remains elusive. In the present study, we showed that DNA (cytosine-5) methyltransferase 3a (Dnmt3a) was upregulated at both the mRNA and protein level during the CI stage, and resulted in increasing promoter methylation of adipogenic genes. We further identified that the expression of Activator protein 2α (AP2α), a member of the transcription factor activator protein 2 (AP2) family, was highly correlated with the expression of Dnmt3a during the CI stage. In addition, we showed that AP2α transcriptionally upregulated Dnmt3a by directly binding to its proximal promoter region. Importantly, treatment of 3T3-L1 preadipocytes with AP2α-specific siRNAs inhibited the preadipocyte differentiation in a stage-dependent manner, supporting the conclusion that AP2α has an important role during the CI stage. Furthermore, overexpression of Dnmt3a partially rescued the impairment of adipogenesis induced by AP2α knockdown. Collectively, our findings reveal that AP2α is an essential regulator for granting preadipocyte the ability to differentiate through the upregulation of Dnmt3a expression during the CI stage.
Topological magnetoplasmon
Authors: Jin Dafei , Lu Ling , Wang Zhong , Fang Chen , Joannopoulos John D. , Soljačić Marin , Fu Liang , Fang Nicholas X. 
Published: November 2016

AbstractClassical wave fields are real-valued, ensuring the wave states at opposite frequencies and momenta to be inherently identical. Such a particle–hole symmetry can open up new possibilities for topological phenomena in classical systems. Here we show that the historically studied two-dimensional (2D) magnetoplasmon, which bears gapped bulk states and gapless one-way edge states near-zero frequency, is topologically analogous to the 2D topological p+ip superconductor with chiral Majorana edge states and zero modes. We further predict a new type of one-way edge magnetoplasmon at the interface of opposite magnetic domains, and demonstrate the existence of zero-frequency modes bounded at the peripheries of a hollow disk. These findings can be readily verified in experiment, and can greatly enrich the topological phases in bosonic and classical systems.