bluuebunny/crossref_metadata_2025_split huggingface dataset:
Boundaries From Borders: Cross-Border Relationships in the Context of the Mental Perception of a Borderline – Experiences from Spanish-French and Polish-German Border Twin Towns
Authors: Markuszewska Iwona , Tanskanen Minna , Subirós Josep Vila 
Published: June 2016

Abstract
In this paper, the borderlands, in the context of the psychological perception of frontiers, were presented. The common relationships between different nationalities living in border twin towns was a principal point of analysis. During the investigation two main research questions were asked: Is a frontier a barrier or a bridge in the common relationships between nationalities living on both sides of the borderline? and Does the trans-border casual social integration stimulate openness to neighbours? The study was conducted in two double towns: la Jonquera (Els límits) - Le Perthus at the Spanish-French border and Słubice - Frankfurt-am-Oder at the Polish-German border. The data were gathered from surveys by questioning locals and visitors during street polling. The design of the questionnaire included three main groups of questions relating to: 1) the perception of the borderline and the role of the border twin towns, 2) the attitude towards neighbours and identification with the borderlands, and 3) the future of the borderline in the context of the twin towns existence and cross-border linkages. The results showed that the historical circumstances and cultural background play a crucial role in the current bilateral interrelations between nations sharing the common space of the twin towns. These two aspects of the borderland have an influence on the psychological perception of the border that creates mental boundaries in local societies. However, as the results proved, the necessity of living together pushed locals to be more open-minded, which as a consequence supported the establishment of social bonds.
Serum Levels of Oxidative Stress Markers in Patients with Type 2 Diabetes Mellitus and Non-alcoholic Steatohepatitis
Authors: Casoinic F. , Sampelean D. , Buzoianu Anca D. , Hancu N. , Baston Dorina 
Published: June 2016

Abstract
Introduction. Oxidative stress is one of the key mechanisms responsible for disease progression in non-alcoholic fatty liver disease. The aim of this study was to evaluate the serum levels of oxidative stress markers in patients with type 2 diabetes mellitus (DMT2) and non-alcoholic steatohepatitis (NASH) and test their relationships with clinical and biochemical patient characteristics, compared to patients with DMT2 without non-alcoholic fatty liver disease (NAFLD), and controls.
Materials and methods. In all, 60 consecutive patients with DMT2 and NASH, 55 with DMT2 without NAFLD, and 50 age-and-gender-matched healthy subjects participated in the study. The serum levels of protein carbonyls and 8-isoprostane were determined by ELISA methods, while the serum levels of malondialdehyde (MDA) were detected by means of the spectrophotometric method. Clinical, demographic, and laboratory parameters were examined for all the subjects included in the study. Multivariate logistic regression was used to test the independent predictive factors in the relationships investigated here.
Results. Patients with DMT2 and NASH displayed significantly higher serum levels of protein carbonyls (1.112 ± 0.42 nmol/dL), MDA (6.181 ± 1.81 ng/mL), and 8-isoprostane (338.6 ± 98.5 pg/mL) compared to patients with DMT2 without NAFLD, and controls. Results of multivariate logistic regression analyses indicate that in patients with DMT2 and NASH, the serum levels of oxidative stress markers were independently and positively associated with: HbA1c, duration of diabetes, the UKPDS cardiovascular risk score (for protein carbonyls); age, LDL-cholesterol (for 8-isoprostane); and triglycerides serum levels (for MDA).
Conclusions. Our findings indicate that the process of oxidative stress tends to increase in patients with DMT2 and NASH, compared to patients with DMT2 without NAFLD, and controls. This evidence suggests that an antioxidant therapy might prove useful in the treatment of patients with DMT2 and NASH.
EEG Abnormalities as Diagnostic and Prognostic Factor for Encephalitis
Authors: Gavrilovic Aleksandar , Drakulic Svetlana Miletic , Matic Tatjana Boskovic , Vesic Katarina , Aleksic Dejan , Toncev Slavco , Gavrilovic Jagoda 
Published: June 2016

Abstract
The aim of the study is to examine whether EEG abnormalities in patients with encephalitis might be prognostic and diagnostic factors for final epilepsy outcome and/or be correlated with the severity of the disability.
The most frequent causes of encephalitis were HSV, WNV, INF V, MTB, St PN, St AU. There was a highly statistically significant positive correlation between the severity of the EEG abnormalities at the beginning of the disease (r = 0.410, p <0.01) and the ultimate outcome.
Electroencephalography in the early stages of encephalitis shows diagnostic and prognostic significance and, in combination with the overall severity of the clinical picture, could contribute to the diagnosis and assessment of outcomes and, ultimately, the correction of treatment and faster recovery of patients. This is particularly true for viral encephalitis.
Possible Uses of Data from Hospital Discharge Reports
Authors: Kocic Sanja , Vasiljevic Dragan , Radovanovic Snezana , Radevic Svetlana , Vukomanovic Ivana Simic , Mihailovic Natasa 
Published: June 2016

Abstract
Almost all countries in the world keep some form of hospital discharge report (HDR). Although there are many variations, every report contains such data as patient demographics, the main cause of hospitalization, comorbidities, the length of stay in hospital and outcome. The advantages of using data obtained from HDRs are numerous: The data from HDRs are already collected in a designated centre and thus easily available and relatively cheap; HDRs contain information for many previous years; they are sometimes more reliable than data obtained through any other method; and finally, they provide a large and representative database. HDRs databases can be connected with other databases using a unified patient identification number. The limitations of using data obtained through HDRs are as follows: inconsistencies in defining and coding diagnoses and applied procedures, common underestimations of comorbidity, limited possible applications in specific studies and partial coverage of inpatient institutions. The prediction that in the future, a growing number of diagnostic and treatment procedures will be performed on an outpatient basis will also limit the use of HDRs. When electronic recordkeeping becomes a practice, we may assume that these data will no longer be needed. There is no perfect model for collection and processing data regarding hospitalized patients. HDRs, with their advantages and disadvantages, currently represent the best way to perceive the size, type, quality and efficiency of the health care services provided to patients at the secondary and tertiary level.
Encopresis in Children: An Overview of Recent Findings
Authors: Vuletic Biljana 
Published: June 2016

Abstract
The term ‘encopresis’, derived from ancient Greek ἐγκόπρησις / egkóprēsis, which means stool, was first introduced in 1926 by Weissenberg to describe the loss of stool in underwear as the faecal equivalent of enuresis. The soiling of underwear is defined as the accidental passage of very small amounts of faeces into underpants. Quantitatively, the content of stool between encopresis and soiling is difficult to determine, and it is especially difficult for parents assess it. Therefore, a new term was adopted – faecal incontinence – that encompasses both encopresis and soiling.
Faecal incontinence is defined as the discharge of faeces in socially awkward situations at least once per month in children ≥ 4 years old. In approximately 95% of cases, faecal incontinence in children is not organic in origin, but instead appears as a functional gastrointestinal disorder. In 80% of children with functional faecal incontinence, the symptoms are associated with functional constipation. The remaining 20% of the cases involve no signs of faecal retention and are defined as non-retentive functional faecal incontinence.
This paper aims to present the latest findings within this area of paediatric gastroenterology.
Ranks of permutative matrices
Authors: Hu Xiaonan , Johnson Charles R. , Davis Caroline E. , Zhang Yimeng 
Published: June 2016

Abstract
A new type of matrix, termed permutative, is defined and motivated herein. The focus is upon identifying
circumstances under which square permutative matrices are rank deficient. Two distinct ways, along
with variants upon them are given. These are a special kind of grouping of rows and a type of partition in
which the blocks are again permutative. Other, results are given, along with some questions and conjectures.
Investigation on the Film Cooling Performance of Diffuser Shaped Holes with Different Inclination Angles
Authors: Zhai Ying-Ni , Liu Cun-Liang , He Yi-Hong , Zhou Zhi-Xiang 
Published: June 2016

AbstractFilm cooling performances of laidback hole and laidback fan-shaped hole have been investigated using transient liquid crystal measurement technique. For film cooling of laidback hole, the increase of inclination angle reduces the film cooling effectiveness under small blowing ratio, while produces better film coverage and higher film cooling effectiveness under larger blowing ratios. Heat transfer coefficient is higher in the upstream region of laidback hole film cooling with large inclination angle, while laidback hole with small inclination angle has relatively higher heat transfer coefficient in the downstream region. The increase of inclination angle reduces the film cooling effectiveness and heat transfer coefficient of laidback fan-shaped hole film cooling, especially in the upstream region. Increase of inclination angle is beneficial to the thermal protection of laidback hole film cooling under large blowing ratio. Film hole with large inclination angle has larger discharge coefficient due to smaller aerodynamic loss in the hole.
Magnetic Field and Slip Effects on the Flow and Heat Transfer of Stagnation Point Jeffrey Fluid over Deformable Surfaces
Authors: Turkyilmazoglu Mustafa 
Published: June 2016

Abstract
The Mhd slip flow and heat transfer of stagnation point Jeffrey fluid over deformable surfaces are the state of the art of this article. Following an analytical approach, the existence, uniqueness, and possible multiplicity of the physical solutions affected by several physical parameters are investigated. Particularly, magnetic interaction and slip factor are shown to much influence the structure of the solutions regarding both momentum and thermal boundary layers. The presented exact solutions not only provide a clear understanding of fruitful physical mechanisms present in this nonlinear flow problem but they have also merits in calculations by means of numerous numerical schemes aiming to explore further complex phenomena.
Hypoglycemic activity of Gleditsia caspica extract and its saponin-containing fraction in streptozotocin-induced diabetic rats
Authors: El Awdan Sally A. , Abdel Jaleel Gehad A. , Saleh Dalia O. , Abdel Basset Marawan , Melek Farouk R. , Kassem Iman A.A. , Badawi Manal 
Published: June 2016

Abstract
The fruits of Gleditsia species (Fabaceae) have been known in traditional medicine as a saponin-rich herbal medicine. The present study aimed to investigate the effects of the total methanolic extract of Gleditsia caspica (MEGC) and its saponin-containing fractions (SFGC) on hyperglycemia in streptozotocin (STZ)-induced diabetic rats. A single intraperitoneal injection of STZ (55 mg/kg body weight) was used to induce hyperglycemia in male albino rats. MEGC (15, 30 and 60 mg/kg, p.o.) and SFGC (15, 30 and 60 mg/kg, p.o.) were administered to the diabetic rats daily for 14 days. The anti-diabetic drug gliclazide (10 mg/kg, p.o.) was used as a positive control. Blood samples were collected from overnight fasted rats for the evaluation of the antihyperglycemic, antihyperlipidemic and antioxidant activities. The levels of glucose, triglycerides (TG), cholesterol (TC) and malondialdehyde (MDA) were increased significantly, whereas the levels of α-amylase, insulin and reduced glutathione (GSH) were decreased in the experimental diabetic rats. Pancreas and liver of the diabetic rats exhibited significant changes in the histopathology, morphology and DNA content. Administration of MEGC or SFGC led to a decrease in the levels of glucose, TG, TC and MDA. In addition, the levels of α-amylase, insulin and GSH were increased in MEGC and SFGC treated diabetic rats. Also, the histopathological and morphological changes, as well the changes in DNA were significantly reversed by the extracts. Thus, MEGC and SFGC exhibited potent hypoglycemic and hypolipidemic activities in STZ- induced diabetic rats.
SLC26A11 (KBAT) in Purkinje Cells Is Critical for Inhibitory Transmission and Contributes to Locomotor Coordination
Authors: Rahmati Negah , Vinueza Veloz Maria Fernanda , Xu Jie , Barone Sharon , Rodolfo Ben Hamida Nahuel , Schonewille Martijn , Hoebeek Freek E. , Soleimani Manoocher , De Zeeuw Chris I. 
Published: June 2016

AbstractChloride homeostasis determines the impact of inhibitory synaptic transmission and thereby mediates the excitability of neurons. Even though cerebellar Purkinje cells (PCs) receive a pronounced inhibitory GABAergic input from stellate and basket cells, the role of chloride homeostasis in these neurons is largely unknown. Here we studied at both the cellular and systems physiological level the function of a recently discovered chloride channel, SLC26A11 or kidney brain anion transporter (KBAT), which is prominently expressed in PCs. Using perforated patch clamp recordings of PCs, we found that a lack of KBAT channel in PC-specific KBAT KO mice (L7-KBAT KOs) induces a negative shift in the reversal potential of chloride as reflected in the GABAA-receptor-evoked currents, indicating a decrease in intracellular chloride concentration. Surprisingly, bothin vitroandin vivoPCs in L7-KBAT KOs showed a significantly increased action potential firing frequency of simple spikes, which correlated with impaired motor performance on the Erasmus Ladder. Our findings support an important role for SLC26A11 in moderating chloride homeostasis and neuronal activity in the cerebellum.
Relationship between Continuity of Care and Adverse Outcomes Varies by Number of Chronic Conditions among Older Adults with Diabetes
Authors: DuGoff Eva H. , Bandeen-Roche Karen , Anderson Gerard F. 
Published: June 2016

Background Continuity of care is a basic tenant of primary care practice. However, the evidence on the importance of continuity of care for older adults with complex conditions is mixed. Objective To assess the relationship between measurement of continuity of care, number of chronic conditions, and health outcomes. Design We analyzed data from a cohort of 1,600 US older adults with diabetes and ≥1 other chronic condition in a private Medicare health plan from July 2010 to December 2011. Multivariate regression models were used to examine the association of baseline continuity (the first 6 months) and the composite outcome of any emergency room use or inpatient hospitalization occurring in the following 12-month period. Results After adjusting for baseline covariates, high known provider continuity (KPC) was associated with an 84% (adjusted odds ratio 0.16; 95% confidence interval 0.09–0.26) reduction in the risk of the composite outcome. High KPC was significantly associated with a lower risk of the composite outcome among individuals with ≥6 conditions. However, the usual provider of care and continuity of care indices were not significantly related with the composite outcome in the overall sample or in those with ≥6 conditions. Conclusion The relationship between continuity of care and adverse outcomes depends on the measure of continuity of care employed. High morbidity patients are more likely to benefit from continuity of care interventions as measured by the KPC, which measures the proportion of a patient's visits that are with the same providers over time.
Las mutaciones de la conciencia de Jean Gebser: una revisión crítica desde la evolución biológica y cultural
Authors: Mestres Naval Francesc , Vives Rego Josep 
Published: June 2016

En este artículo desarrollamos una serie de apreciaciones y consideraciones acerca de las ideas de Gebser sobra las estructuras de la conciencia. Para explicar su aparición él utilizó el símil de las “mutaciones”. Los nuevos conocimientos en la Evolución biológica sirven para potenciar y revalorizar sus ideas. En el ser humano a partir de esta Evolución biológica surge la evolución cultural, y ambas son fundamentales para el desarrollo de la conciencia. Evolución significa cambio en el tiempo y este último concepto es crucial para Gebser. Pensamos que el dominio del tiempo caracterizará la nueva estructura integral de la conciencia humanahttp://dx.doi.org/10.15304/ag.35.2.2823
Determinant of The Poverty in The Moslem Countries: Ibn Khaldun Development Model
Authors: Putra Dian Paisal , Indra Indra 
Published: June 2016

This current paper examined the determinant of the poverty in the OIC countries. Our empirical model was based on Ibn Khaldun development model that emphasizes several aspects, namely: the country's wealth (proxied by GDP per capita), the role of government (proxied by health and education expenditures), human resources (proxied by HDI), sharia (proxied by corruption perception index), development (proxied by investment), and justice (proxied by Gini index). We used panel data model consisting nine OIC countries over 2003-2012. This study verified that GDP per capita significantly contribute to the reduction of poverty in the OIC countries. We also found that unemployment (as a control variable) encountered a role in triggering poverty in OIC countries. Meanwhile, it found that education expenditure, Gini index, HDI, and Corruption Perception Index found no significant effect on poverty. DOI: 10.15408/sjie.v5i1.3130
Cleft Palate and Aglossia Result from Perturbations in Wnt and Hedgehog Signaling
Authors: Yuan Gongjie , Singh Gurpreet , Chen Serafine , Perez Kristy Carrington , Wu Yan , Liu Bo , Helms Jill Ann 
Published: June 2016

Objective The objective of this study was to explore the molecular basis for cleft secondary palate and arrested tongue development caused by the loss of the intraflagellar transport protein, Kif3a. Design Kif3a mutant embryos and their littermate controls were analyzed for defects in facial development at multiple stages of embryonic development. Histology was employed to understand the effects of Kif3a deletion on palate and tongue development. Various transgenic reporter strains were used to understand how deletion of Kif3a affected Hedgehog and Wnt signaling. Immunostaining for structural elements of the tongue and for components of the Wnt pathway were performed. BrdU activity analyses were carried out to examine how the loss of Kif3a affected cell proliferation and led to palate and tongue malformations. Results Kif3a deletion causes cranial neural crest cells to become unresponsive to Hedgehog signals and hyper-responsive to Wnt signals. This aberrant molecular signaling causes abnormally high cell proliferation, but paradoxically outgrowths of the tongue and the palatal processes are reduced. The basis for this enigmatic effect can be traced back to a disruption in epithelial/mesenchymal signaling that governs facial development. Conclusion The primary cilium is a cell surface organelle that integrates Hh and Wnt signaling, and disruptions in the function of the primary cilium cause one of the most common—of the rarest—craniofacial birth defects observed in humans. The shared molecular basis for these dysmorphologies is an abnormally high Wnt signal simultaneous with an abnormally low Hedgehog signal. These pathways are integrated in the primary cilium.
Patient Counseling and Management of Symptoms During Olaparib Therapy for Recurrent Ovarian Cancer
Authors: Moore Kathleen N. , Monk Bradley J. 
Published: June 2016

Abstract
Our primary objective is to review the safety and tolerability profile of olaparib, a novel anticancer therapy, and to discuss key considerations for symptom management in patients with advanced ovarian cancer. Olaparib is the first of a new class of anticancer therapies, poly (ADP-ribose) polymerase (PARP) inhibitors that target tumors that have deficits in homologous recombination repair (such as BRCA mutations) by a process known as synthetic lethality. Through this process, neither the deficiency in homologous recombination repair nor PARP inhibition alone is cytotoxic, but the combination of these two conditions leads to cell death. In December 2014, olaparib received accelerated approval by the U.S. Food and Drug Administration (FDA) as monotherapy for patients with known or suspected deleterious germline BRCA-mutated (as detected by an FDA-approved test) advanced ovarian cancer who had been treated with at least three lines of chemotherapy. Most adverse events (AEs) reported during olaparib clinical trials conducted in patients with recurrent ovarian cancer and measurable disease were of grade 2 or less severity according to the National Cancer Institute’s Common Terminology Criteria for Adverse Events. Fatigue and gastrointestinal AEs are among the most common in ovarian cancer clinical trials and can be particularly bothersome to patients. We focus on interventions to address these AEs in patients who are candidates for treatment with olaparib and allow them to remain on therapy for as long as clinically indicated.
Clinical Implications of the Progression-Free Survival Endpoint for Treatment of Hormone Receptor-Positive Advanced Breast Cancer
Authors: Kaklamani Virginia G. 
Published: June 2016

Abstract
Hormonal therapy for advanced breast cancer (ABC) has evolved significantly since the introduction of tamoxifen more than 40 years ago. The availability of selective antiestrogen therapies has further improved treatment options for women with hormone receptor-positive (HR+) ABC. However, with the development of resistance to hormonal therapies, a new treatment paradigm has emerged based on our understanding of biological pathways involved in HR+ breast cancer and mechanisms of resistance to hormonal therapy. Recent drug development efforts have focused on combining hormonal treatment with agents that target mammalian target of rapamycin serine-threonine kinases and cyclin-dependent kinases. In parallel with the evolution of hormonal and targeted therapies, our understanding of the utility of clinical endpoints has deepened. Progression-free survival (PFS) is a primary endpoint well-understood by clinicians and is increasingly accepted as a surrogate for overall survival (OS) by the U.S. Food and Drug Administration. Yet the perceived clinical benefit of PFS to patients is less well understood. Patients may not grasp the implications of prolonged PFS, highlighting the reality that patient preference in treatment selection encompasses factors that extend beyond drug activity. This presents an opportunity for clinicians to discuss PFS with patients in the context of their treatment plans, clinical outcomes, and quality-of-life measures. The objective of this review is to explore the clinical validity of the PFS and OS endpoints and the clinical relevance of PFS and OS to patients, especially in light of drivers that led to a range of treatment options for patients with HR+ ABC.