bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive impairment in patients with obesity and impaired carbohydrate metabolism (dysglycemia)
Authors: Dzgoeva F. Kh. , Ekusheva E. V. , Demidova V. V. 
Published: September 2024

Obesity is a chronic disease, heterogeneous in etiology and clinical manifestations, progressing with a natural course, characterized by excessive deposition of fat mass in the body. This pathological condition has taken on the scale of a global epidemic in recent years, which continues to progress steadily, currently affecting more than 2 billion people worldwide. Due to its heterogeneity, obesity has a negative impact on the work of almost all organs and systems of the body, contributing to the emergence of new concomitant diseases and pathological conditions that significantly worsen the quality of life of these patients. Thus, a close relationship between type 2 diabetes mellitus and cognitive impairment has long been known, as well as with a number of other somatic diseases: coronary heart disease, atherosclerosis, non-alcoholic fatty liver disease, dyslipidemia, malignant neoplasms and other associated pathological conditions against the background of overweight and obesity.Currently, the problem of the relationship of cognitive impairment in patients with overweight or changes in the glycemic profile is very relevant, due to the high prevalence and insufficient study of this issue.
Summary of the 2023 European Society of Cardiology clinical guidelines on the management of cardiovascular disease in patients with diabetes mellitus
Authors: Erlikh A. D. , Zilov A. V. , Shchekochikhin D. Y. , Shornikov S. B. , Bublik E. V. , Vinogradskaya O. I. , Grishkovets A. I. , Farmanov A. G. , Ryzhkova E. G. 
Published: September 2024

The prevalence of cardiovascular diseases (CVDs) is well known. According to the World Health Organization (WHO), almost 18 million people die from CVDs worldwide every year, accounting for 31% of all causes of death [1]. CVDs often develop concomitantly with diabetes mellitus (DM), with approximately 20% of cardiovascular deaths attributed to elevated blood glucose levels [2]. Notably, CVDs are the leading cause of death among patients with type 2 diabetes (T2DM). Based on data from the Federal Register of Diabetes 2022 in Russia, chronic heart failure was the direct cause of death in 24.2% of T2DM cases, followed by acute heart failure (13.1%), cerebrovascular events (10.0%), and myocardial infarction (3.7%) [3].The pathophysiological interplay between atherosclerotic cardiovascular disease and DM has led to a situation where cardiologists are increasingly involved in the treatment of patients with DM, while endocrinologists are encountering a growing number of patients with CVDs. This association has become so apparent that in a recent article published in the European Journal of Cardiology, Yu. Braunwald speculated about the emergence of a new subspecialty - diabetocardiology [4]. Unfortunately, experts predict that the global number of diabetic patients will reach 783 million [5].Recent data on the CV benefits of certain hypoglycemic drugs (primarily, certain SGLT2 inhibitors, several GLP-1 receptor agonists, and a novel non-steroidal mineralocorticoid receptor antagonist finerenone) prove the need for a unified interdisciplinary approach to managing CVDs and DM.Given the importance of integrated and coordinated efforts in managing patients with CVD and DM, the Task Force of the ­European Society of Cardiology (ESC) updated, formulated, and published clinical guidelines on the treatment of CVD in diabetic patients in 2023 [6]. This article provides a concise overview of the key provisions outlined in the guidelines.
The application of cell products for the treatment of critical limb ischemia in patients with diabetes mellitus: a review of the literature
Authors: Chugan G. S. , Lyundup A. V. , Bondarenko O. N. , Galstyan G. R. 
Published: September 2024

The number of patients with diabetes mellitus (DM) has been progressively increasing worldwide over the past decades, and many international organizations consider DM as a public health emergency of the 21st century.Critical limb ischemia (CLI) is the most severe stage of peripheral arterial disease (PAD) in DM and is characterized by a high risk of limb loss without revascularization. Traditional treatment tactics include open and endovascular revascularization surgical techniques. However, in patients not eligible for revascularization and in cases where performed surgical treatment performed has been ineffective, there are almost no therapeutic alternatives, often leading to amputations and death. As of today, one of the newest non-surgical treatment options is cell therapy. Among different cells, mesenchymal stromal cells (MSCs) are potentially one of the most prospective for use in this patient population.This article provides an overview of clinical trials using cell therapy in patients with CLI.To analyze publications, electronic databases PubMed, SCOPUS, ClinicalTrials, and ScienceDirect were searched to identify published data from clinical trials, research studies, and review articles on cell therapy for critical lower extremity ischemia. After the search, 489 results were received.As a result of systematic selection, 22 clinical trials were analyzed.According to the analyzed literature data, the use of cell products in this category of patients is effective and safe. Cell therapy can stimulate the formation of new vessels and enhances collateral circulation; it is also reported improved distal perfusion, increased pain-free walking distance, decreased amputation rates, and increased survival rates.Nevertheless, further study of the potential use of this category of drugs is needed.
Flow and heat transfer insights into a chemically reactive micropolar Williamson ternary hybrid nanofluid with cross-diffusion theory
Authors: Khan Muhammad Naveed , Ahmad Shafiq , Wang Zhentao , Hussien Mohamed , Alhuthali Abdullah M. S. , Ghazwani Hassan Ali 
Published: September 2024

Abstract
The need for efficient nanotechnology has led to unexpected developments. Conserving continuous thermal propagation is essential in many industrial and thermal systems because it improves the efficiency of thermal engineering engines and machinery. Therefore, a promising platform to increase thermal power energy is the hybridization of magnetic nanoparticles in a heat-supporting, non-Newtonian fluid. In light of the above applications, a mathematical model is established to analyze the variable fluid features of the thermally radiative and chemically reactive flow of a micropolar Williamson ternary hybrid nanofluid with electromagnetohydrodynamic and electroosmosis forces on a porous stretching surface. Stratification boundary conditions and variable fluid properties were used to analyze the thermal and solutal behavior of the fluid flow. Furthermore, to measure the disorder of the flow system, entropy generation was considered by the impact of Joule heating and viscous dissipation. To develop the numerical scheme BVP4C in MATLAB, we first converted the mathematical flow model into two ordinary differential equations using a suitable transformation. The graphical and numerical results were determined against several parameters of a ternary hybrid nanofluid

(

MWCNT
,

A

l

2

O

3

,

SiC

)

({\rm{MWCNT}},\hspace{0.25em}{\rm{A}}{{\rm{l}}}_{2}{{\rm{O}}}_{3},\hspace{0.25em}{\rm{SiC}})

and unary nanofluid

(

A

l

2

O

3

)

({\rm{A}}{{\rm{l}}}_{2}{{\rm{O}}}_{3})

. The results indicate that the heat transfer rate is more prominent in the ternary hybrid nanofluid than in the unary nanofluid because the addition of nanofluids to the base fluid is used to improve the heat transport rate. It can be seen from the figures that a greater estimation of the magnetic and electric field parameters improves the fluid velocity because, for low values of

M
≤
1

M\le 1

, the aiding force is dominant compared to the retarding force, which results in an improvement in the velocity profile. Furthermore, the entropy generation rate increases for higher values of the Brinkman number and temperature ratio parameter because more heat is produced due to the greater values of

Br

{\rm{Br}}

.
Evaluation of the Utilization of Web-based Library Application Information Systems using Whitebox and Blackbox Testing Methods
Authors: Pamungkas Ananda Cipta , Samihardjo Rosalin 
Published: September 2024

The library information system is a computerized process for integrated data management. This research was conducted in the library located at SMAN 12 Bandung, Jl. Sekejati No. 36, Sukapura. The importance of performance measurement. The validity of implementation from the perspective of effectiveness and efficiency of web-based libraries is the main thing in the aim of managing library digitalization. This research was carried out using the Whitebox and Blackbox Testing integration method. The purpose of the research is to conduct an Information Technology Audit with the validity of measuring the effectiveness and efficiency of application functions. The research results show that the technical analysis of FlowGraph Whitebox is based on source code and flowcharts running on Cyclomatic Complexity which counts the number of nodes and edges in FlowGraph. Research implications support the assessment of the concrete validity of the method used. This can be seen from the research results that the performance of the Web-based Widyantara Library application at SMAN 12 Bandung is considered satisfactory with a good level of validity, this is proven by the test results using the white box testing method. Meanwhile, based on the analysis of the black box testing method on application functionality, the test results are said to be good with a validity percentage reaching 100%. Validity according to application design is proven by testing 10 application scenarios.
Health Services Use for SARS-CoV-2–Infected Children With Croup or Bronchiolitis
Authors: Tyler Amy , Bakel Leigh Anne , Tucker Joshua , Moss Angela , Kille Briana , Rifken Katharine , Forrest Christopher B. , Schroeder Alan , Jhaveri Ravi , Christakis Dimitri , Muszynski Jennifer , Khaitan Alka , Morizono Hiroki , Fitzgerald Megan , Pajor Nathan , Bunnell Timothy , Bailey L. Charles , Rao Suchitra 
Published: September 2024

BACKGROUND AND OBJECTIVES
Croup and bronchiolitis are common reasons for hospitalization in children, and the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on utilization outcomes for these conditions is not well understood. To compare health care utilization including the rates of hospitalization, readmission, length of stay, and ICU admission for croup and bronchiolitis in children with and without evidence of concurrent SARS-CoV-2 infection over the pandemic period.

METHODS
This retrospective cohort study used inpatient and outpatient electronic health record data from PEDSnet institutions to examine health services use for children aged 30 days to 14 years with SARS-CoV-2 infection and diagnosed with croup or bronchiolitis. The time frame (March 2020–May 2022) was divided into predelta, delta, and omicron variant periods. Multivariable mixed effects logistic and log gamma regression models were used to calculate adjusted odds ratios for factors linked to utilization outcomes for children with versus without SARS-CoV-2 infections. Disease burden was described by variant time period.

RESULTS
Across all time periods, among subjects with croup and bronchiolitis, 9.65% of croup patients and 3.92% of bronchiolitis patients were SARS-CoV-2–positive. The omicron variant period had the highest number of SARS-CoV-2 cases for both croup and bronchiolitis. After controlling for patient-level variables and hospital variability, we found no statistically significant differences in utilization outcomes comparing children with and without SARS-CoV-2.

CONCLUSIONS
Pediatric patients with croup and bronchiolitis and positive SARS-CoV-2 polymerase chain reaction testing did not exhibit a significant increase in hospital and ICU admissions, which may have implications for future staffing models and public health recommendations.
Digital Detox and Well-Being
Authors: Marciano Laura , Jindal Sanmit , Viswanath Kasisomayajula 
Published: September 2024

In a May 2023 advisory, the US Surgeon General raised concerns about the effects of social media use on well-being. One implied strategy to reduce its impact is abstaining from digital media use. This state-of-the-art review summarizes the most recent studies on reducing or abstaining from digital media use, including social media (ie, “digital detox”) and its effect on well-being to inform parents, educators, schools, policymakers, and the public when taking action. In June 2023, we conducted a literature search in Google Scholar, PubMed, and ScienceDirect. We included reviews and original research articles (1) focusing on interventions to reduce screen time/social media time and (2) its impact on/association with well-being. We summarized the key points of the 2 published reviews and 6 articles (published between 2013 and 2023), including 139 articles in total. Our main findings are: there is no clear definition of digital detox and no consistency in the assessment of interventions’ effectiveness;reducing social media/smartphone time rather than promoting total abstinence showed more beneficial effects on well-being;the effect of the interventions and their duration varies depending on the type of outcome; andthe effects are influenced by gender, age, and contextual factors.Available evidence on interventions aiming at reducing social media use on well-being is limited, leaving no clear implications for policymaking at this point. More empirical, high-quality research is needed to understand the circumstances under which digital detox interventions are helpful and for whom.
Percepción de las evaluaciones formativas y sumativas en los estudiantes cuarto semestre de la carrera de enfermería en una universidad Pública del Ecuador
Authors: Quiroz Figueroa Martha , Lucas Cho´éz Mercedes María , Delgado Bernal Doris Susana , Delgado Molina Jaqueline Beatriz 
Published: September 2024

Introducción. La evaluación para el aprendizaje o evaluación formativa desempeña un papel clave en la mejora del aprendizaje de los estudiantes, permiten medir el progreso que contribuye a que al final del semestre se generen evaluaciones sumativas para la aprobación o desaprobación del semestre.
Objetivo. Analizar la percepción de las evaluaciones formativas y sumativas en los estudiantes de cuarto de semestre de la carrera de enfermería.
Método. Se realizó un estudio observacional, descriptivo y transversal, el universo estuvo constituido por 113 estudiantes de cuarto semestre, la muestra constituida de manera aleatoria simple por 88 participantes, con un nivel de confianza del 95%; y un margen de error del 5%. Se utilizó la escala validada inventario de preferencias de evaluación estructurada por 69 ítems categorizadas en 3 dimensiones. El análisis estadístico de los datos se hizo a través de estadística descriptiva para el cálculo de media, desviaciones estándar, frecuencias y porcentajes mediante la utilización del programa SPSS versión 25.0 con licencia adquirida.
Resultados. El rango de edad de los estudiantes de cuarto semestre oscila 19 a 25 años, y el genero que predomina es el femenino, en las preferencias de evaluación los estudiantes prefieren las evaluaciones de opción múltiple y en menor direccionamiento las pruebas escritas y examen oral. En el enfoque de rol y responsabilidad consideran es factible que el docente de una lista de preguntas del examen entre las cuales puedan elegir y consideran hacer que los estudiantes realicen las preguntas del examen en menor ponderación.

Conclusiones. Las evaluaciones que el docente realiza directamente son evaluaciones sumativas durante el proceso de enseñanza y aprendizaje en la formación de enfermeros de una universidad pública, y se relacionan con las percepciones de los estudiantes, que denotan las debilidades en las evaluaciones formativas que son fundamentales para retroalimentar cada actividad que se imparte, a fin de identificar brechas de aprendizaje y brindar Feedback positivo que permite contribuir a la formación del conocimiento teórico practico.
Human in the Loop: Decoding MPD Incidents Using Practical Human Factors
Authors: Kvalo P. E. M. , Duarte M. , Laird E. 
Published: September 2024

Abstract
To err is human. The definition of error is not abstract, error is used as a catch-all term that encompasses the failures of planned actions to achieve their intended outcome. Conversely, the root cause of an error is up to debate and tied to an organization's and/or individual's viewpoint. The old view of Human Error is based on the philosophy that systems are inherently safer than humans and as such by minimizing human interactions and removing them from the loop; the result is a safer-less error-prone system. This inherently identifies humans as the root cause of most errors. The new view is based on the theory that human errors are unavoidable and are a symptom of a systemic problem and rarely the root cause. A focus on the human element is pivotal in the prevention of errors within any given system. The emergence of automated systems decreases individuals' interaction with progressively complex systems while increasing cognitive workloads. These critical processes can often lead to errors if Human Factors are not accounted for.
Most MPD operations include critical human-in-the-loop interactions that must be designed around human factors such as sensory overload, distractibility, input device deficiencies, communication failures, cognitive workloads, time pressure, and fatigue. Understanding the intricacies of Practical Human factors and its role in safe drilling operations will provide a path forward to mitigate errors and identify root causes when they occur.
An Integrated Workflow for Improved Lateral Placement in Underbalanced Coiled Tubing Drilling Operations
Authors: Al Abdrabalnabi H. , Abu Alsaud S. , Malik H. 
Published: September 2024

Abstract
This paper describes an integrated workflow that was developed to identify sweet spot and maximize lateral placement in underbalanced coiled tubing drilling (UBCTD). As fields mature and become more challenging, UBCTD becomes an effective solution to extract hydrocarbon. In some implementations, UBCTD encounters drilling challenges that result in shorter laterals or lower net-to-gross ratio than planned. Effective lateral placement precision in sweet spot is one of the main requirements to optimize productivity of oil and gas reservoirs. The constructed workflow maps key operational indicators extracted from offset wells to drive optimized well placement and maximized gas output.
The workflow involves selecting key indicators from multiple offset wells to identify vertical and spatial variations. These variation profiles are generated based on a pattern and trends with highest success rates across available data. Based on the ideal productivity profile identified and the matched target well placement, the operational plan is then integrated with seismic data to boost lateral placement accuracy across the target. Developed data maps and actual gas rate are assessed to verify placement accuracy, and call for decisions to adjust well trajectory plans in real time.
The introduced solution has demonstrated improvements in lateral placement by utilizing key operational indicators from offset wells data. The workflow was conducted on a synthetic thin carbonate reservoir box, where the generated stratigraphic window was adjusted based on an optimal performance data. The data collected during UBCTD operations was further inverted to enhance and improve operations. The developed workflow pinpoints operations variation and allows steering corrections to place the lateral within the expected target, where gas flow readings will confirm reliability of the operation parameters and thus model robustness and validity.
The process implemented focuses on integrating real-time data to optimize predictive models and avoids drilling non-reservoir footage. In addition, the workflow accounts for time delay challenge between bit position and logging tools in the bottom hole assembly during data acquisition.
Automating Influx Management Envelope (IME) Generation Through Cloud-Based Solutions
Authors: Zhou L. , Liu Y. , Anfinsen B. , Hashemian Y. , Yuan Z. , Gilje A. 
Published: September 2024

Abstract
This study focuses on automating the generation of Influx Management Envelopes (IME) for MPD through a digital cloud-based solution, aiming to simplify the process for routine application in drilling operations. The integration of digital cloud-based solutions and parallel computing enhances the efficiency of IME generation by parameterizing various influx scenarios. Utilizing a transient multiphase flow engine, the study establishes kick tolerance thresholds for safe influx volume determination. The analysis includes assessing associated risks during kick circulation using MPD system. Parallel computing ensures faster computations and improved scalability. The combined approach integrates simulation results into an operational envelope for safer decision-making. The study emphasizes the importance of applying and enforcing company well control policies, integrating corporate rules into every simulation for adherence to established guidelines and maintain a consistent and standardized approach to well control practices. Collaborative workflows are highlighted as essential, fostering seamless teamwork, communication, and coordination. The integration of a collaborative framework enables effective sharing of expertise and contributes significantly to a comprehensive understanding of drilling operations. Additionally, the capability to review and approve simulations within this environment enhances accountability, quality control, and adherence to industry best practices in MPD.
Valorization of Green Market Waste as a Renewable Energy Source
Authors: Ozmihci Serpil , Hacıoğlu İlknur , Karapınar İlgi , Küs Meltem 
Published: September 2024

Abstract

High organic carbon wastes can be used for biofuel production for reducing raw material costs. Green market wastes (GMW) are one of the raw material candidates to generate biofuel by fermentation with low-cost production and high yield of fuel formation. Biohydrogen and biomethane are potential gaseous energy sources that can be obtained through sequential fermentation of GMW. In this study, the ground and hydrolyzed GWM (a mixture of lettuce, parsley, spring onion, and dill) solid-liquid mixture was first valorized for biohydrogen, then the organic acid-rich residue of biohydrogen fermentation was subjected to biomethane production. Biohydrogen and biomethane was produced at mesophilic (37°C) and thermophilic (55°C) temperatures. The initial GWM amount varied between 1000-5000 g wb at mesophilic biohydrogen production. The highest cumulative hydrogen formation (CHF) and the rate were obtained at 5000 g wb as CHF=8.9 L and 916 mL H2 /L day, respectively. Thermophilic biohydrogen fermentation was conducted at 1000 and 5000 g wb and CHF reached to 14.2 L at 5000 g wb GMW. The yield of hydrogen formation was 1.6 times higher at thermophilic than that of mesophilic conditions. The residues from two fermentation temperatures of 5000 g wb GMW were used to produce biomethane under both fermentation conditions. Mesophilic and thermophilic conditions resulted in cumulative biomethane formations (CMFs) of 8.3 L and 5.8 L, and biomethane production yields of 0.17 mL CH4/g VFA and 0.13 mL CH4/g VFA, respectively. The findings revealed that GMW is a suitable substrate for efficient biohydrogen and biomethane production.