bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continuous Glucose Monitoring Measures Can Be Used for Glycemic Control in the ICU: An In-Silico Study
Authors: Zhou Tony , Dickson Jennifer L. , Shaw Geoffrey M. , Chase J. Geoffrey 
Published: November 2017

Background: Continuous glucose monitoring (CGM) technology has become more prevalent in the intensive care unit (ICU), offering potential benefits of increased safety and reduced workload in glycemic control (GC). The drift and higher point accuracy errors of CGM devices over traditional intermittent blood glucose (BG) measures have so far limited their application in the ICU. This study delineates the trade-offs of performance, safety and workload that CGM sensors provide in GC protocols. Methods: Clinical data from 236 patients were used for clinically validated virtual trials. A CGM-enabled version of the STAR GC protocol was used to evaluate the use of guard rails and rolling windows. Safety was assessed through percentage of patients who had a severe hypoglycemic episode (BG < 40 mg/dl) as well as percentage of resampled BG < 72 mg/dl. Performance was assessed as percentage of resampled measurements in the 80-126 mg/dl and the 80-144 mg/dl target bands. Workload was measured by number of manual BG measures per day. Results: CGM-enabled versions of STAR decreased the number of required blood draws by up to 74%, while maintaining performance (76.6% BG measurements in the 80-126 mg/dl range vs 62.8% clinically, 87.9% in the 80-144 mg/dl range vs 83.7% clinically) and maintaining patient safety (1.13% of patients experienced a severe hypoglycemic event vs 0.85% clinically, 1.37% of BG measurements were less than 72 mg/dl vs 0.51% clinically). Conclusion: CGM sensor traces were reproduced in virtual trials to guide GC. Existing GC protocols such as STAR may need to be adjusted only slightly to gain the benefits of the increased temporal measurements of CGM sensors, through which workload may be significantly decreased while maintaining GC performance and safety.
Pharmacotherapy in overactive bladder
Authors: Hopkinson VCG , Pearce I 
Published: November 2017

Overactive bladder syndrome (OAB) has a high prevalence within the population and has a negative effect on quality of life. Although the precise pathophysiology has yet to be fully elucidated, pharmacotherapeutic agents have been developed targeting two main pathways, antimuscarinic drugs and β3-adrenoreceptor agonists. Conservative management strategies, for example, bladder training, should be used as first-line treatment, with pharmacotherapy used as an adjunct if this is insufficiently effective. Antimuscarinics have a moderate effect on treating the symptoms of OAB, are associated with side effects, particularly dry mouth, and have low adherence rates in the long term. No single agent has consistently shown superiority over another. Antimuscarinics can affect cognition and may contribute to the anticholinergic burden in elderly patients. Mirabegron, a β3-agonist, appears to be as effective as antimuscarinics in improving symptoms of OAB with fewer side effects and improved adherence, and is currently recommended if treatment with antimuscarinics has failed. A combination of an antimuscarinic and β3-agonist may be worth considering if symptoms remain refractory or to reduce the side-effect profile associated with higher doses of antimuscarinics. Level of evidence: Not applicable.
Stereotactic Body Radiotherapy for Early-Stage Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American Society for Radiation Oncology Evidence-Based Guideline
Authors: Schneider Bryan J. , Daly Megan E. , Kennedy Erin B. , Antonoff Mara B. , Broderick Stephen , Feldman Jill , Jolly Shruti , Meyers Bryan , Rocco Gaetano , Rusthoven Chad , Slotman Ben J. , Sterman Daniel H. , Stiles Brendon M. 
Published: November 2017

Purpose The American Society for Radiation Oncology (ASTRO) produced an evidence-based guideline on treatment with stereotactic body radiotherapy (SBRT) for patients with early-stage non–small-cell lung cancer. ASCO has a policy and set of procedures for endorsing and/or adapting clinical practice guidelines that have been developed by other professional organizations. Methods The ASTRO Evidence-Based Guideline for Stereotactic Body Radiotherapy for Early-Stage Non–Small-Cell Lung Cancer was reviewed for developmental rigor by methodologists. An ASCO Expert Panel updated the literature search and reviewed the guideline content and recommendations. Results The ASCO Expert Panel determined that the recommendations from the ASTRO guideline, published in 2017, are clear, thorough, and based on the most relevant scientific evidence. ASCO statements and minor modifications were added to enhance the applicability of the ASTRO guideline for the broader ASCO audience. Recommendations For standard operative risk patients with stage I NSCLC, SBRT is not recommended outside of a clinical trial. Lobectomy with systematic lymph node evaluation remains the recommended treatment, although a sublobar resection may be considered in select clinical scenarios. Recommendations are provided regarding the use of SBRT in high operative risk patients and for inoperative patients, including in challenging scenarios where tumors are: centrally located, > 5 cm in diameter, lacking tissue diagnosis, synchronous primary or multifocal, second primary after pneumonectomy, proximal to or involved with mediastinal structures, abutting the chest wall, or recurring after previous treatment. Qualifying statements are included to provide further guidance for implementation, and the importance of a discussion of treatment options among members of the multidisciplinary cancer care team is emphasized. Additional information is available at: www.asco.org/thoracic-cancer-guidelines and www.asco.org/guidelineswiki .
Understanding the aetiology and resolution of chronic otitis media from animal and human studies
Authors: Bhutta Mahmood F. , Thornton Ruth B. , Kirkham Lea-Ann S. , Kerschner Joseph E. , Cheeseman Michael T. 
Published: November 2017

ABSTRACTInflammation of the middle ear, known clinically as chronic otitis media, presents in different forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative otitis media (CSOM). These are highly prevalent diseases, especially in childhood, and lead to significant morbidity worldwide. However, much remains unclear about this disease, including its aetiology, initiation and perpetuation, and the relative roles of mucosal and leukocyte biology, pathogens, and Eustachian tube function. Chronic otitis media is commonly modelled in mice but most existing models only partially mimic human disease and many are syndromic. Nevertheless, these models have provided insights into potential disease mechanisms, and have implicated altered immune signalling, mucociliary function and Eustachian tube function as potential predisposing mechanisms. Clinical studies of chronic otitis media have yet to implicate a particular molecular pathway or mechanism, and current human genetic studies are underpowered. We also do not fully understand how existing interventions, such as tympanic membrane repair, work, nor how chronic otitis media spontaneously resolves. This Clinical Puzzle article describes our current knowledge of chronic otitis media and the existing research models for this condition. It also identifies unanswered questions about its pathogenesis and treatment, with the goal of advancing our understanding of this disease to aid the development of novel therapeutic interventions.
Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia
Authors: Lin Hong , Magrane Jordi , Rattelle Amy , Stepanova Anna , Galkin Alexander , Clark Elisia M. , Dong Yi Na , Halawani Sarah M. , Lynch David R. 
Published: November 2017

ABSTRACT
Friedreich ataxia (FRDA), the most common recessive inherited ataxia, results from deficiency of frataxin, a small mitochondrial protein crucial for iron-sulphur cluster formation and ATP production. Frataxin deficiency is associated with mitochondrial dysfunction in FRDA patients and animal models; however, early mitochondrial pathology in FRDA cerebellum remains elusive. Using frataxin knock-in/knockout (KIKO) mice and KIKO mice carrying the mitoDendra transgene, we show early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in this FRDA model. At asymptomatic stages, the levels of PGC-1α (PPARGC1A), the mitochondrial biogenesis master regulator, are significantly decreased in cerebellar homogenates of KIKO mice compared with age-matched controls. Similarly, the levels of the PGC-1α downstream effectors, NRF1 and Tfam, are significantly decreased, suggesting early impaired cerebellar mitochondrial biogenesis pathways. Early mitochondrial deficiency is further supported by significant reduction of the mitochondrial markers GRP75 (HSPA9) and mitofusin-1 in the cerebellar cortex. Moreover, the numbers of Dendra-labeled mitochondria are significantly decreased in cerebellar cortex, confirming asymptomatic cerebellar mitochondrial biogenesis deficits. Functionally, complex I and II enzyme activities are significantly reduced in isolated mitochondria and tissue homogenates from asymptomatic KIKO cerebella. Structurally, levels of the complex I core subunit NUDFB8 and complex II subunits SDHA and SDHB are significantly lower than those in age-matched controls. These results demonstrate complex I and II deficiency in KIKO cerebellum, consistent with defects identified in FRDA patient tissues. Thus, our findings identify early cerebellar mitochondrial biogenesis deficits as a potential mediator of cerebellar dysfunction and ataxia, thereby providing a potential therapeutic target for early intervention of FRDA.
Prospective observational research on the clinical profile and outcome analysis among a cohort of patients sustaining traumatic cervical spine and cord injury in a peripheral tertiary spine care centre in Nepal
Authors: Munakomi Sunil , Bhattarai Binod , Cherian Iype 
Published: November 2017

Background: In developing nations like Nepal, spinal cord injury has multispectral consequences for both the patient and their family members. It has the tendency to cripple and handicap the patients, and burn out their caretakers, both physically and mentally. Furthermore, the centralization of health care with only a handful of dedicated rehabilitation centers throughout Nepal further places patients into disarray. This study was carried out as a pilot study to determine the modes of injury, age groups affected, clinical profiles and patterns of injury sustained, as well as the efficacy of managing a subset of patients, who have sustained cervical spine and cord injuries. Methods: This was a prospective cohort study comprising of 163 patients enrolled over a period of three years that were managed in the spine unit of College of Medical Sciences, Bharatpur, Nepal. Results: Road traffic accidents were implicated in 51% of these patients. 65% of them were in the age group of 30-39 years. Traumatic subluxation occurred in 73 patients with maximum involvement of the C4/5 region (28.76%). Good outcome was seen in patients with ASIA ‘C’ and ‘D’ with 55% of patients showed improvement from ‘C’ to ‘D’ and 95% of patients showed improvement from ‘D’ to ‘E’ at 1 year follow up. The overall mortality in the patients undergoing operative interventions was only 1.98%. Conclusions: The prevalence of cervical spine injuries in the outreach area is still significant. The outcome of managing these patients, even in the context of a resource limited setup in a spine unit outside the capital city of a developing nation, can be as equally as effective and efficient compared to the outcome from a well-equipped and dedicated spine unit elsewhere.
The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa (ALPHA): Data on mortality, by HIV status and stage on the HIV care continuum, among the general population in seven longitudinal studies between 1989 and 2014
Authors: Slaymaker Emma , McLean Estelle , Wringe Alison , Calvert Clara , Marston Milly , Reniers Georges , Kabudula Chodziwadziwa Whiteson , Crampin Amelia , Price Alison , Michael Denna , Urassa Mark , Kwaro Daniel , Sewe Maquins , Eaton Jeffrey W. , Rhead Rebecca , Nakiyingi-Miiro Jessica , Lutalo Tom , Nabukalu Dorean , Herbst Kobus , Hosegood Victoria , Zaba Basia 
Published: November 2017

Timely progression of people living with HIV (PLHIV) from the point of infection through the pathway from diagnosis to treatment is important in ensuring effective care and treatment of HIV and preventing HIV-related deaths and onwards transmission of infection. Reliable, population-based estimates of new infections are difficult to obtain for the generalised epidemics in sub-Saharan Africa. Mortality data indicate disease burden and, if disaggregated along the continuum from diagnosis to treatment, can also reflect the coverage and quality of different HIV services. Neither routine statistics nor observational clinical studies can estimate mortality prior to linkage to care nor following disengagement from care. For this, population-based data are required. The Network for Analysing Longitudinal Population-based HIV/AIDS data on Africa brings together studies in Kenya, Malawi, South Africa, Tanzania, Uganda, and Zimbabwe. Eight studies have the necessary data to estimate mortality by HIV status, and seven can estimate mortality at different stages of the HIV care continuum. This data note describes a harmonised dataset containing anonymised individual-level information on survival by HIV status for adults aged 15 and above. Among PLHIV, the dataset provides information on survival during different periods: prior to diagnosis of infection; following diagnosis but before linkage to care; in pre-antiretroviral treatment (ART) care; in the first six months after ART initiation; among people continuously on ART for 6+ months; and among people who have ever interrupted ART.
Reducing missed opportunities for vaccination in selected provinces of Mozambique: A study protocol
Authors: Magadzire Bvudzai Priscilla , Joao Gabriel , Shendale Stephanie , Ogbuanu Ikechukwu Udo 
Published: November 2017

Background: A missed opportunity for vaccination (MOV) refers to any contact with health services by an individual who is eligible for vaccination, which does not result in the person receiving the vaccine doses for which he or she is eligible. A consortium of partners, including VillageReach, the Ministry of Health in Mozambique and the World Health Organization, will implement a strategy to reduce MOV in Mozambique. The strategy involves demonstrating the magnitude of missed opportunities and their causes, and exploring tailored health system interventions to reduce them, with the aim of increasing vaccination coverage and timeliness of vaccinations. Methods: A mixed-methods approach will incorporate both quantitative and qualitative tools. The assessment will target caregivers of children between the ages of 0–23 months who attend a health facility in the selected districts on the day of the assessment. Caregivers who are at least 18 years old will be eligible for inclusion. Another component of the assessment will target all health workers in the selected health facilities on the day of the assessment. A sample of 30 health facilities in different regions of the country will be assessed, with a target sample size of 600 caregiver exit interviews, 300 health worker interviews and focus group discussions with both caregivers and health workers. Data collection will commence late 2017, and the data will be electronically captured, managed and analyzed. Thematic analysis of data from the qualitative aspects of the assessment will be conducted, presenting the scope of interviews, representative verbatim quotes and key conclusions. Conclusions: A concerted effort to reduce or eliminate MOV could increase vaccine coverage by up to 30% and may contribute to wider improvements in efficiencies of service delivery beyond the immunization program. In addition, the findings could contribute to a better understanding of MOV in similar settings.
Techno-Economic Analysis of Solar Absorption Cooling for Commercial buildings in India
Authors: Narayanan Muthalagappan 
Published: November 2017

Space cooling and heating always tends to be a major part of the primary energy usage. By using fossil fuel electricity for these purposes, the situation becomes even worse. One of the major electricity consumptions in India is air conditioning. There are a lot of different technologies and few researchers have come up with a debate between solar absorption cooling and PV electric cooling. In a previous paper, PV electric cooling was studied and now as a continuation, this paper focuses on solar thermal absorption cooling systems and their application in commercial/office buildings in India. A typical Indian commercial building is taken for the simulation in TRNSYS. Through this simulation, the feasibility and operational strategy of the system is analysed, after which parametric study and economic analysis of the system is done. When compared with the expenses for a traditional air conditioner unit, this solar absorption cooling will take 13.6 years to pay back and will take 15.5 years to payback the price of itself and there after all the extra money are savings or profit. Although the place chosen for this study is one of the typical tropical place in India, this payback might vary with different places, climate and the cooling demand.Article History: Received May 12th 2017; Received in revised form August 15th 2017; Accepted 1st Sept 2017; Available onlineHow to Cite This Article: Narayanan, M. (2017). Techno-Economic Analysis of Solar Absorption Cooling for Commercial Buildings in India. International Journal of Renewable Energy Development, 6(3), 253-262.https://doi.org/10.14710/ijred.6.3.253-262
The Effects of Different Roughness Configurations on Aerodynamic Performance of Wind Turbine Airfoil and Blade
Authors: Jafari Kamyar , Djavareshkian Mohammad Hassan , Feshalami Behzad Forouzi 
Published: November 2017

In this research, viscous and turbulent flow is simulated numerically on an E387 airfoil as well as on a turbine blade. The main objective of this paper is to investigate various configurations of roughness to find a solution in order to mitigate roughness destructive impacts. Hence, the sand grain roughness is distributed uniformly along pressure side, suction side and both sides during the manufacturing process. Navier-Stokes equations are discretized by the finite volume method and are solved by SIMPLE algorithm. Results indicated that in contrast with previous studies, the roughness will be useful if it is applied on only pressure side of the airfoil. In this condition, the lift coefficient is increased to and 1.2% compare to the airfoil with rough and smooth sides, respectively. However, in 3-D simulation, the lift coefficient of the blade with pressure surface roughness is less than smooth blade, but still its destructive impacts are much less than of both surfaces roughness and suction surfaces roughness. Therefore, it can be deduced that in order to reveal the influence of roughness, the simulation must be accomplished in three dimensions.Article History: Received Jun 12th 2017; Received in revised form August 27th 2017; Accepted Oct 3rd 2017; Available onlineHow to Cite This Article: Jafari, K., Djavareshkian, M.H., Feshalami, B.H. (2017) The Effects of Different Roughness Configurations on Aerodynamic Performance of Wind Turbine Airfoil and Blade. International Journal of Renewable Energy Development, 6(3), 273-281.https://doi.org/10.14710/ijred.6.3.273-281
Pengujian Pengeringan Garam Briket Skala Laboratorium
Authors: Kiono Berkah Fajar Tamtomo , Sony Severianus 
Published: November 2017

Tingginya konsumsi garam beryodium di Indonesia, membuat pemerintah membuat dan mendorong UMKM untuk memproduksi garam beryodium pada jumlah besar. Salah satu provinsi yang mempunyai jumlah UMKM garam yang banyak adalah Provinsi Jawa Tengah. Daerah terbesar produksi garam beryodium adalah Kabupaten Pati. Namun untuk memiliki produktivitas yang tinggi, pabrik garam beryodium yang ada di Pati harus mengganti alat pengeringnya dengan alat pengering yang tepat. Salah satu alat pengering yang harus diganti adalah alat pengering untuk garam briket. Dalam mendesain suatu alat pengering untuk garam briket, perlu dilakukan penelitian mengenai pengeringan garam briket skala laboratorium untuk mengetahui parameter-parameter untuk pengeringan garam. Penelitian ini dilakukan dengan menggunakan oven. Garam dikeringkan dengan menggunakan 1 heater dan 2 heater. Variasi temperatur oven dengan mengubah bukaan damper. Bukaan damper diatur setengah bukaan dan bukaan penuh (WOT/Wide Opening Throttle). Temperatur oven bervariasi dari 120OC sampai 190OC, sedangkan temperatur garam maksimum adalah 108OC.Titik didih garam sangat tingi yaitu 801,1OC, sedangkan titik didih Yodium adalah 184,4OC. Pengujian ini mendapatkan hasil pengeringan berturut-turut sebagai berikut, dengan suhu udara akhir 120OC membutuhkan waktu pengeringan selama 221 menit, sedangkan untuk suhu 130OC waktu pengeringannya adalah 200 menit, dengan suhu akhir 176OC adalah 55 menit, dan pengeringan dengan suhu akhir 200OC adalah 55 menit. Proses pengeringan optimum garam pada suhu 170-180OC dengan waktu pengeringan 19 menit
Chemical aspects related to using recycled geopolymers as aggregates
Authors: Chaliasou Napoleana Anna , Heath Andrew , Paine Kevin , Calabria Holley Juliana 
Published: November 2017

Despite extensive research into sustainability of geopolymers, end-of-life aspects have been largely overlooked. A recycling scenario is examined in this study. This requires an investigation of alkali leaching potential from a geopolymeric matrix. To study the feasibility of geopolymer cement (GPC) recycling, the migration of alkalis was evaluated for the first time on a microstructural level through energy dispersive X-ray (EDX) scanning electron microscopy (SEM) elemental mapping and leaching tests. Macroscale impacts were assessed through an investigation of Portland cement (PC) mortar properties affected by alkali concentration. Leaching tests indicated that alkalis immediately become available in aqueous environments, but the majority remain chemically or physically bound in the matrix. This type of leaching accelerates the initial setting of PC paste. Elemental mapping and EDX/SEM analysis showed a complex paste–aggregate interfacial transition zone. Exchange of calcium and sodium, revealed by the maps, resulted in the migration of sodium into the PC paste and the formation of additional calcium–silicon-based phases in the geopolymeric matrix. Strength values of mortars with 25% and 50% recycled aggregates (RA) showed negligible differences compared with the reference sample. Screening tests indicated a low potential for GPC RA inducing alkali–silica reaction. Transport of GPC RA alkalis and the underlying mechanisms were observed. This transport phenomenon was found to have minor effects on the properties of the PC mortar, indicating that recycling of geopolymers is a viable reuse practice.
Guided Growth: Current Perspectives and Future Challenges
Authors: Yang Irene , Gottliebsen Martin , Martinkevich Polina , Schindeler Aaron , Little David G. 
Published: November 2017

* Guided growth by tethering part of the growth plate is an established technique for the correction of frontal angular deformities about the knee in children.* A better understanding of the underlying conditions, factors affecting longitudinal growth, and mechanism of response of the growth plate to retardation forces could lead to improvement and expansion of this technique to other sites and indications.* This review article highlights areas of future research and outlines the possible future of guided growth techniques.