bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract P360: MicroRNAs: Potential Biomarkers and Therapeutic Targets for Hypertensive Nephropathy
Authors: Al Kayed Hadeel , Altintas Mehmet , Oktay Ahmet 
Published: October 2024

Introduction:
Hypertensive nephropathy (HN) is the second most common cause of end-stage renal disease after diabetic nephropathy. miRNAs are small epigenetic modulators whose levels change in many diseases. This review summarizes the diagnostic and therapeutic potential of miRNAs in HN.

Methodology:
We conducted a thorough literature review on PubMed, including both retrospective and prospective studies on animal and human subjects. Additional references were sourced through cross-referencing the bibliographies of the initial articles.

Results:
Our literature review revealed that intra-renal levels of miR-200a, miR-141, miR-200b, miR-205, miR-429, and miR-192 were elevated in patients with HN. Conversely, intra-renal miR-204-5p levels were decreased, and further reductions in animal models using anti-miR-204-5p or miR-204 gene knockout exacerbated renal injury.

Exposure of renal tissue to exogenous albumin increased intra-renal miR-184 levels, prompting further investigation into whether albumin excretion from kidney injury alters miRNA expression or if miRNA dysregulation initiates kidney injury and subsequent albumin excretion.
Urinary miR-146a, miR-184, and miR-34a levels were lower in patients with albuminuria than those without, whereas urinary miR-200a levels were higher. Interestingly, urinary miR-21 levels increased before the onset of albuminuria in hypertensive mice.
A positive correlation was also observed between miR-208b and miR-133a levels in blood cells and urinary albumin excretion (UAE). Notably, plasma levels of miR-let-7g-5p and miR-191-5p correlated positively with eGFR but not with UAE. Since miRNA levels varied based on the sampling source, a pivotal study identified a consistent miRNA profile in HN patients, showing that miR-208a and miR-301a were upregulated in urine yet downregulated in plasma.
The therapeutic potential of miRNAs was highlighted by an animal study showing that the knockdown of miR-103a-3p can nullify albuminuria in hypertensive mice.

Conclusion:
The role of miRNAs in HN is increasingly evident. Studies have linked varying miRNA expression profiles in patients with HN, and specific miRNAs were detectable earlier than albuminuria. Furthermore, certain miRNAs correlate with eGFR independently of UAE. Targeting specific miRNAs, using miRNA mimics and anti-miRNAs, could underpin preventive and therapeutic strategies. These findings advocate for further research into miRNAs as potential biomarkers and therapeutic targets for HN.
Abstract P421: Differential Osmolyte Profiles in Hypertensive and Normotensive Rats.
Authors: Ufnal Marcin , Tomasova Lenka , Szudzik Mateusz , Maksymiuk Klaudia 
Published: October 2024

Hypertension is known to be associated with water-electrolyte balance disturbances that lead to changes in osmotic pressure. Osmolytes are small organic molecules essential for cellular adaptation to changes in osmotic pressure.
This study investigates the levels of osmolytes in serum and tissues using two well-established rat models of hypertension: spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats with angiotensin II-induced hypertension (WKY-ANG).
Experiments were conducted on male Wistar-Kyoto (WKY) rats, SHRs, and WKY-ANG rats. Blood and tissue samples were collected from all groups for liquid chromatography with mass spectrometry (LC-MS) analysis of selected osmolytes.
Anesthetized SHR and WKY-ANG rats displayed significantly elevated mean arterial blood pressures compared to WKY rats (118.4±1.3, 110.2±0.9, and 76.5±1.2 mmHg, respectively). The serum and tissue levels of sarcosine were significantly decreased in SHRs compared to WKY rats (1.90±0.21 vs. 3.80±0.80 for serum, 55.55±9.79 vs 92.37±10.57 for liver, 6.06±0.78 vs. 10.55±1.19 for renal cortex, 9.14±0.45 vs.13.83±1.14 for renal medulla, 11.59±1.17 vs. 22.34±3.11 for lungs, 1.80±0.14 vs. 3.30±0.39 for heart, respectively). Reduced levels of beta-alanine were observed only in the serum of SHRs compared to WKY and WKY-ANG rats (6.48±0.93 vs. 59.43±9.47, 41.32±3.13 respectively). Additionally, higher levels of L-alanine were noted in the renal cortex and medulla of WKY than in SHRs and WKY-ANG rats (19685±592.3 vs. 14510±456.8, 14289±719.4 for cortex and 14043±560.3 vs. 11520±206.8, 10651±292.4 for medulla, respectively). Conversely, SHR rats exhibited significantly higher levels of serum glycerophosphocholine (GPC) than WKY-ANG rats (38.21±10.02 vs. 12.47±2.25). Simultaneously, lower levels of betaine were observed in the lungs of SHR rats when compared to WKY and WKY-ANG rats (1 and 351.20±36.02, 607.10±64.20, 606.70±55.88 for lungs respectively). All results are indicated in μmol/L and means±SE.
In conclusion significant alterations in osmolyte concentrations are evident in hypertensive rats. These findings suggest that hypertension may be associated with disruptions in osmolyte balance. Further studies are needed to assess the potential clinical significance of osmolyte disturbances in hypertension.
Attempting to Break Binary Oppositions of East and West: Hanan Al-Shaykh’s “I Sweep the Sun off Rooftops”
Authors: Balaa Luma 
Published: October 2024

Abstract
Hanan Al-Shaykh’s, “I Sweep the Sun off Rooftops”, calls for cross-cultural dialogue between different cultures. The text explores the cultural tensions that shape an individual’s identity within the postcolonial context. This article examines an encounter in the text between the Moroccan protagonist and her English boyfriend, his sister and his friends in London. Engaging in dialogue between multiple postcolonial theories such as Frantz Fanon’s concept of “absolute depersonalization”, Edward Said’s Orientalism and “contrapuntal consciousness” – Mary Louise Pratt’s theory of transculturation and Homi Bhabha’s notion of “hybridity”, this research studies how the processes of transculturation and hybridity can act to transcend cultural clashes and East–West divisions. The author resorts to using colonial tropes or Orientalist stereotypes to eventually subvert these problems but, at times, this causes ambiguity and contradictions in her text. The female protagonist follows a non-linear trajectory, experiencing various stages before she reaches a hybrid state; these stages involve a fascination with London, cultural clashes, self-assertion and integration, incorporating cultural crossing and hybridity. The female protagonist slips back and forth from one stage to another with all her experiences contributing towards the attainment of cultural dialogue.
Progressive Tension Sutures in Fleur de Lis Abdominoplasty: A Case Report
Authors: Ray Andrew , Baldwin Leah , Zaremba Shelby 
Published: October 2024

Introduction: As the field of cosmetic and plastic surgery progresses patient safety and comfort remain paramount. Over the past 30 years, multiple studies have demonstrated the effectiveness of progressive tension sutures (PTS) in drainless abdominoplasties and case series have been published evaluating the outcomes of PTS/drainless abdominoplasties in high-volume liposuction cases (liposuction with over 3 L of aspirate). To date, there have been no reports in the literature regarding PTS usage in Fleur de Lis (FDL)-type abdominoplasties. Materials/Methods: We describe our experience using PTS in a patient with a drainless FDL abdominoplasty and several patients in which PTS was used to limit the number of drains needed in an FDL abdominoplasty. Results: In our follow-up with the patient, she had no adverse events or seroma formation. Discussion/conclusion: The cases documented here suggest that FDL abdominoplasty can be performed without the need for drains or with minimal drains.
A New Bailout Maneuver to Manage Type IIIa Endoleak Due to Displaced Renal Bridging Stent Graft in Narrow Aorta
Authors: Mezzetto Luca , Grosso Lorenzo , Veraldi Gian Franco 
Published: October 2024

Purpose: To present endovascular management of an intraoperative type IIIc endoleak (EL) in a patient with migration of the right renal artery (RRA) bridging stent graft (BSG) during branched aortic aneurysm repair. Technique: The technique is demonstrated in an 80-year-old woman who underwent branched endograft repair of a symptomatic 6-cm type II TAAA. The t-Branch thoracoabdominal stent graft was positioned without difficulty. A “partial graft deployment” was performed, with the distal portion of the device remaining inside the delivery system and the right renal and superior mesenteric arteries were stented. When the constraining wires were removed, the RRA BSG migration from the branch was displayed, due to endograft twisting resulting in a horizontal rotation of the t-Branch. The RRA BSG remained oriented upward with the proximal edge positioned above the distal edge of the directional branch, making cannulation very difficult. This bailout technique uses a balloon placed at the level of the RRA BSG through the celiac artery (CA) directional branch; keeping the balloon inflated and in thrust, the edge of the BSG has moved downward making it possible to engage it and relining through the RRA directional branch. Conclusions: This paper describes an endovascular bailout technique for relining a displaced bridging stent graft, oriented upwards with the proximal edge positioned above the distal edge of the directional branch. Clinical Impact This sophisticated technique adds to the spectrum of bailout techniques that can be applied in cases of type IIIa EL with migration and complete separation of BSG.
Orbital tuberculosis presenting as vision loss and headache: early management is paramount
Authors: Pal Sandeep , Patidar Narendra , Tomar Gunjan , Gaikwad Himanshu 
Published: October 2024

AbstractOrbital tuberculosis is a rare form of extra pulmonary TB and may arise either by hematogenous route or spread directly from the paranasal sinus. We herein report two cases of orbital TB with a vision threatening complication. Case-1 is a 31-year-old female with a headache, a diminution of vision in the right eye, and pain in ocular movement. On examination, there was no proptosis with RAPD present in right eye and tenderness on palpation. CEMRI revealed a diffuse infiltrating lesion at the orbital apex, suggesting of inflammatory pathology. Case-2 is a 40-year-old male with similar complaints in the left eye, CECT showed edema and swelling in the optic nerve and extraocular muscle of the left eye. A detailed investigation was done, and a diagnosis of orbital tuberculosis was made in both patients. They were started on ATT and oral steroids but lost follow-up initially and due to delayed treatment, it led to irreversible vision loss. A long-term follow-up showed resolution of ocular symptoms with occasional headaches.
Partnership quality and maternal depressive symptoms in the transition to parenthood: a prospective cohort study
Authors: Schwarze Cornelia E. , Lerche Veronika , Wallwiener Stephanie , Pauen Sabina 
Published: October 2024

Abstract
Background
Pregnancy and childbirth are critical life events which lead to significant changes in family structures and roles, thus having a substantial impact on partner relationship and maternal wellbeing. A dysfunctional partnership during this critical time of life has been associated with maternal depressiveness. However, sub-components of partnership quality and the causal relation with maternal symptoms of depression in the perinatal period have been sparsely studied so far. The current study aims to longitudinally assess the course of relationship quality and its sub-components from pregnancy to postpartum and to test a potential causal association with maternal symptoms of depression in the perinatal period.

Methods
Differing from previous studies, partnership quality and symptoms of depression have been assessed prospectively and longitudinally from an early stage of pregnancy (second trimester) until six months postpartum. Cross-lagged panel models were applied to investigate a potential causal relationship between partnership quality and maternal depressive symptoms.

Results
Relationship quality decreased significantly during the transition to parenthood (p < .05) with the steepest decline referring to tenderness (p < .001). We also found a substantial association of relationship quality and maternal depressiveness, but no indication for a clear causal direction of this association.

Conclusions
Our results suggest that relationship quality and maternal depressiveness are substantially related in the perinatal period, thus pointing to the need of early prevention and intervention programs for peripartum women and their partners to prevent adverse outcome for the couple and the family.
Socioecological factors influencing the risk of developing hypertensive disorders of pregnancy in India: a rapid review
Authors: Alur Anumita , Phipps Jennifer E. , Simmons Leigh Ann 
Published: October 2024

Abstract
Background
The prevalence of hypertensive disorders of pregnancy (HDPs) in India is 11%, which is one of the highest rates globally. Existing research on HDPs in India primarily focuses on biological risk factors, with minimal research on how socioecological factors combine to increase risk of HDPs. We conducted a rapid review using Bronfenbrenner’s Ecological Model to understand the social and cultural factors associated with HDPs among Indian pregnant women to identify possible intervention targets that may uniquely improve health in this population. Bronfenbrenner’s Ecological Model is a framework that can be used to understand the complex relationship between multiple influences on health.

Methods
We reviewed studies published between January 2010 and January 2024 using PubMed, Science Direct, and Scopus databases. Search terms included variants of hypertension, pregnancy, and India. Inclusion criteria were: (1) peer-reviewed journal article; (2) published between January 2010 to January 2024; (3) participants consisted of Indian women living in India; (4) studies evaluated socioecological risk factors associated with HDPs. One independent reviewer performed searches, screening, data extraction, and quality assessment. Each included study was then organized within Bronfenbrenner’s Ecological Model.

Results
A total of 921 studies were generated from the initial search, with 157 exclusions due to duplicates. Following screening for inclusion and exclusion criteria at the title/abstract and full text levels, 17 studies remained in the final review. Socioecological risk factors of HDPs were identified at each level, with the most commonly identified influences including: low socioeconomic status (SES), lacking community education and knowledge on HDP management and prevention, and lacking prenatal HDP screening.

Conclusion
This study determined that the high risk for HDPs in India is influenced by many intertwined socioecological factors. Women in rural and low SES areas need more health education on HDP management and prevention. There also needs to be more adequate prenatal HDP screening, with at least 4 and ideally 8 prenatal visits. Prenatal screenings should be accompanied with culturally appropriate patient education, especially for low SES women who have limited literacy, so that they can effectively make individual and microsystemic lifestyle decisions aimed at either managing or preventing HDPs.
Health, economic and social impacts of the Brazilian cash transfer program on the lives of its beneficiaries: a scoping review
Authors: Magalhães Júlia , Ziebold Carolina , Evans-Lacko Sara , Matijasevich Alicia , Paula Cristiane Silvestre 
Published: October 2024

Abstract
Background
The Bolsa Família cash transfer Program (BFP) aims to break the poverty cycle by providing a minimum income to poor families conditioned on their investment in human capital (such as, education and health) and currently is the largest Program in the world in terms of the number of beneficiaries. Because there is a scarcity of reviews grouping studies on the impacts of the BFP, the objective of this scoping review was to identify and describe studies which evaluate the impact of the BFP on poverty, health, education, and other related outcomes.

Methods
We searched for quantitative, qualitative, and mixed-method articles that assessed the impact of the BFP on any aspect of the beneficiaries' lives between 2003 and March 2021. We included quantitative articles that used experimental, quasi-experimental or pre and post comparison designs. We excluded articles that analyzed impacts on political outcomes. There was no age restriction for the participants. The search was done in seven electronic databases.

Results
One thousand five hundred forty-six papers were identified and 94 fulfilled the inclusion criteria. Poverty and health outcomes were the most common outcomes studied. We found consistent evidence of the positive impact of the BFP on poverty reduction, as well as employment outcomes. We also found positive impacts in relation to mortality rates for children and adults, school dropout and school attendance among children and adolescents, and violence related outcomes such as homicide, suicide, crime, and hospitalization. However, we also found some evidence that BFP increased intimate partner violence and gender stereotypes among women and no evidence of impact on teenage pregnancy.

Conclusions
Overall, the studies included found that BFP showed positive impacts on most poverty, health and education outcomes. More studies are needed to confirm some results, especially about violence and stereotype against women as there were few evaluations on these outcomes.
Reliability assessment of the ‘field audit for children’s active transport routes to school’ (FACTS) tool
Authors: Vasey Thomas V. , Dale Michael J. , Carroll Suzanne J. 
Published: October 2024

Abstract
Background
Children’s active travel to school is associated with physical activity and thus health. Safe Routes to School (SR2S) programs identify ‘safe routes’ to promote children’s active travel to school. No field audit tool exists specifically to assess the microscale built environment of these ‘safe routes’ within Australia. This study describes the reliability assessment of the Field Audit for Children’s Active Transport to School (FACTS) tool.

Methods
The FACTS tool was developed using a multi-step process, including a literature search, expert opinion, and pilot testing. For the reliability assessment, two trained auditors collected data at eight schools over three weeks in April 2021. For inter-rater reliability, auditors conducted audits on the ‘safe routes’ for the same six schools. For intra-rater reliability, auditors conducted repeat measures on the ‘safe routes’ for four schools each (eight schools total), including three different schools each from the six used for inter-rater reliability and one additional school. Item-by-item reliability was assessed using Cohen’s Kappa, Cohen’s Weighted Kappa, and percentage agreement. The reliability of calculated domain scores was assessed using intraclass correlation coefficients.

Results
For inter-rater reliability, 31 of the 45 (68.9%) items had moderate to almost perfect agreement, seven items (15.6%) had below moderate agreement, and a Kappa statistic could not be calculated for seven items (15.6%) due to constant values. For intra-rater reliability, 37 of the 45 (82.2%) items had moderate to almost perfect agreement, two items (4.4%) had below moderate agreement, and a Kappa statistic could not be calculated for six items (13.3%) due to constant values. For inter- and intra-rater reliability of the segment domain scores, three of the four domains had substantial to almost perfect agreement. For inter- and intra-rater reliability of the crossing domain scores, all four domains had moderate to almost perfect agreement. For inter- and intra-rater reliability of the segment, crossing, route, and school scores, all had substantial to perfect agreement.

Conclusions
The FACTS tool can reliably characterise the microscale built environment of promoted ‘safe routes’ for their use within SR2S programs, and should be considered for use in future SR2S programs within the suburban Australian context.
Exploring the effects of COVID-19 outbreak control policies on services offered to people experiencing homelessness
Authors: Davis Alexa J. , Halperin Donna M. , Condran Brian R. , Kervin Melissa S. , Di Castri Antonia M. , Salter Katherine L. , Bettinger Julie A. , Parsons Janet A. , Halperin Scott A. 
Published: October 2024

Abstract
Background
The COVID-19 pandemic and subsequent implementation of public health policies exacerbated multiple intersecting systemic inequities, including homelessness. Housing is a key social determinant of health that played a significant part in the front-line defence against COVID-19, posing challenges for service providers working with people experiencing homelessness (PEH). Public health practitioners and not-for-profit organizations (NFPs) had to adapt existing COVID-19 policies and implement novel measures to prevent the spread of disease within congregate settings, including shelters. It is essential to share the perspectives of service providers working with PEH and their experiences implementing policies to prepare for future public health emergencies and prevent service disruptions.

Methods
In this qualitative case study, we explored how service providers in the non-profit sector interpreted, conceptualized, and implemented COVID-19 public health outbreak control policies in Nova Scotia. We interviewed 11 service providers between September and December 2020. Using thematic analysis, we identified patterns and generated themes. Local, provincial, and national policy documents were useful to situate our findings within the first year of the COVID-19 pandemic and contextualize participants’ experiences.

Results
Implementing policies in the context of homelessness was difficult for service providers, leading to creative temporary solutions, including pop-up shelters, a dedicated housing isolation phone line, comfort stations, and harm reduction initiatives, among others. There were distinct rural challenges to navigating the pandemic, which stemmed from technology limitations, lack of public transportation, and service closures. This case study illustrates the importance of flexible and context-specific policies required to support PEH and mitigate the personal and professional impact on service providers amid a public health emergency. Innovative services and public health collaboration also exemplified the ability to enhance housing services beyond the pandemic.

Conclusions
The results of this project may inform context-specific emergency preparedness and response plans for COVID-19, future public health emergencies, and ongoing housing crises.