bluuebunny/crossref_metadata_2025_split huggingface dataset:
Device that safely closes the incisions made with trocars in laparoscopic surgery
Authors: Padilla Luis , Montoya-Ramírez Jesús , Aguilar-Soto Oscar , Herran-Motta Fanny Stella , Landero-Yoshioka Takeshi , López-Gutiérrez Javier , Carranza-Castro Carranza-Castro , Nuño-Lámbarri Natalia , Ortega-Salgado José Arturo , Ortiz-Fernández Moisés , Silvio Mauricio Di , Montalvo-Javé Eduardo Esteban 
Published: September 2024

Abstract

Objective:
To describe and demonstrate the safety and efficacy of an OcluPad (OP) that closes surgical incisions in the abdominal wall, made with trocars in laparoscopic surgery in obese patients, avoiding hernias.
Material and methods:
After preclinical studies in rats and pigs, we obtained authorization from the Research, Ethics, and Biosafety commissions of the "20 de Noviembre" National Medical Center to develop a clinical trial and apply the OP device to 40 of the 80 patients subjected to Gastric bypass or gastric sleeve surgery as a surgical treatment for morbid obesity. The patients were divided into two groups: Group I, 40 patients with three OP devices applied to close the trocar holes, and Group II, 40 patients without surgical closure of the three trocar holes.
Results:
The groups were evaluated two years after the bariatric surgery procedure using abdominal tomography. Obtaining zero hernias in group I and 14 hernias in group II generated a 35% prevalence. (p = 0.001) (OR = 0.04) CI = 0.005–0.38.
Conclusions:
OP is a device that prevents the formation of trocar hernias in obese patients. It is efficient, simple, quick to apply, economical, and meets the concept of safety and effectiveness since it has excellent biocompatibility; generating a layer of neo-mesothelium induces minimal adhesions.
POEMS syndrome combined with anti-Caspri1 antibody-mediated autoimmune nodo-paranodopathy: a case report
Authors: Zou xuan , Hong Yan , Zhou Guanen 
Published: September 2024

Abstract

Background POEMS syndrome is a rare paraneoplastic syndrome caused by abnormal proliferation of plasma cells. It can cause multiple peripheral neuropathy, but the specific mechanism is still unclear. we describe a case of POEMS syndrome combined with anti-Caspri1 antibody-mediated autoimmune nodo-paranodopathy.Case presentation A 66-year-old male patient developed flaccid paralysis of the limbs after diarrhea two months ago. He was diagnosed with POEMS syndrome 4 years ago. The titer of the IgG antibody against contact associated protein1 (Caspr1) in the patient's serum was 1:100, and the IgG and IgM antibodies against GM1 were weakly positive. Brain MRI shows left paraventricular infarction, accompanied by cerebrovascular stenosis, severe heart failure, and pleural effusion. The patient's condition improved after receiving plasma exchange (PE) and methylprednisolone treatment.Conclusion There is report of POEMS syndrome combined with anti-GM1 antibody1, but there has been no report of POEMS syndrome combined with anti-Caspr1 antibody. Abnormal plasma cell proliferation in POEMS syndrome may be the culprit behind the production of antibodies.
Estimates of non-communicable disease expenditure by disease phase, sex, and age group for all OECD countries
Authors: Grimshaw Samantha , Bourke Emily , Blakely Tony 
Published: September 2024

Abstract

Background:
Across OECD member countries, non-communicable diseases (NCDs) accounted for nearly 90% of deaths and over half of disability-adjusted life years lost. NCD health expenditure estimates are necessary to estimate future health expenditure trajectories for different prevention and treatment policies. However, no dataset of comparable estimates exists across OECD countries.
This study generates disease expenditure estimates in all 38 OECD member countries in 2019, for 80 major NCDs by disease phase, sex, and age group – filling a critical information gap in global health data.
Methods:
Health expenditure per person with disease by sex and age group was taken from a comprehensive Australian disease expenditure study and disaggregated by disease phase (first year of diagnosis, last year of life if dying of disease, otherwise prevalent) using Global Burden of Disease data and New Zealand estimates of relative expenditure ratios by phase. These estimates were applied to case numbers in each OECD country and scaled to each country’s total health system expenditure to estimate total NCD expenditure in 2019 United States dollars by disease phase. Estimates were compared with pre-existing disease expenditure estimates for Norway, Switzerland, and the United States of America.
Results:
Average health expenditure on NCDs across OECD countries was US$207 million per 100,000 population. Pooled across countries, musculoskeletal disorders contributed to the highest proportion of total health expenditure (17.4%), followed by cancer and other neoplasms (9.4%), and CVD (9.1%). The highest proportion expenditure conditions for females were musculoskeletal disorders (56.1%), mental and substance use disorders (55.8%), and neurological conditions (54.8%). For males it was kidney and urinary diseases (63.8%), cancer and other neoplasms (58.3%), and cardiovascular diseases (50.7%). The first year of diagnosis represented on average 36.8% of total NCD expenditure, while last year of life expenditure attributable to disease causing death accounted for 2.6%.
Similarities and differences were observed between our estimates and pre-existing country-specific estimates.
Conclusions:
Our estimates represent a starting point for understanding the impact of NCDs on health system expenditure. We recommend evolving our paper’s methods to include multiple country-level studies as inputs – augmented by covariates (e.g. GDP, public/private split) to better predict disease expenditure.
Phase Angle and Body Composition in Long-term Type 1 Diabetes in Adults: A comparative study in a Brazilian Public Reference Outpatient Clinic
Authors: Pena Natália Fenner , Fajardo Virginia Capistrano , Froes Lívia , Carvalho Paulo Augusto Miranda , Lauria Márcio Weissheimer , Torres Henrique Oswaldo da Gama 
Published: September 2024

Abstract

Introduction: Type 1 Diabetes Mellitus (DM1) is a disease that affects a small percentage of the population. Nevertheless prevalence is currently growing, with alarming data on lack of control. The importance of body composition and Phase Angle (PA) as assessed by Bioelectrical Impedance (BIA) in long term DM1 patients lies in the fact that alterations in cellular integrity and body compartments may affect risk profiles and metabolic control. The objective of this study was to compare different PA and body composition parameters in a sample of adults with DM1, with healthy controls.
Methods: A comparative study was carried out in a state public university outpatient clinic, including a cohort of adult patients of both sexes, diagnosed with DM1, and a control group matched by age and sex, in a 2:1 ratio. Anthropometric measurements included weight, height and BMI. From the raw bioelectrical impedance data of Resistance and Reactance, Fat-Free Mass (FFM), Fat Mass (FM), Fat-Free Mass Index (FFMI), Fat Mass Index (FMI), PA and standardized PA (SPA) were calculated. Means or medians were compared. Regression models were used to show distinguishing characteristics of both groups or to disclose associations within the diabetic group (HbA1c, disease duration, presence of microvascular complications, capillary blood glucose, BMI and FMI).
Results: 88 patients with Type 1 Diabetes and 46 healthy controls were evaluated. PA was lower in diabetics (6.05 vs 6.85, p = 0.000), as well as SPA (-1.47 vs -1.36, p = 0.000). Diabetics displayed higher adiposity (%FM = 29.6 vs 27.6, p = 0.016; FMI = 7.00 vs 6.33, p= 0.016) and lower %FFM. Most of the differences were maintained after sex stratification and diabetic man disclose a lower FFMI than male controls (18.2 vs20.16, p = 0.029).
Conclusion:Patients with DM1 present greater nutritional risk and worse cell membrane integrity when assessed by PA. Significant body composition differences among groups and between sexes were highlighted, with data showing greater adiposity in diabetic women and diabetic men displaying lower muscle mass. These findings suggest the importance including PA and body composition evaluation in the multidisciplinary clinical outpatient follow-up of patients with Type 1 Diabetes, in an attempt to obtain better metabolic control and consequently, a better prognosis.
The Relationship Between Gratitude and Coping Strategies: A Mediation Analysis Based on Longitudinal Cross-sectional Data
Authors: ZHANG Jun , YIN Zhimin , DENG Ping , YANG Jieying 
Published: September 2024

Abstract

Purpose This study evaluated the potential relationship between gratitude and coping strategies, examining the mediating effects of perceived social support and self-esteem between gratitude and coping strategies. Methods Starting from January 2023, our research team conducted three longitudinal surveys on 2018 high school students, using Mplus software to construct a structural equation model to explore the relationships between gratitude, coping strategies, perceived social support, and self-esteem. Results Gratitude can significantly predict coping strategies directly and indirectly through perceived social support and self-esteem. Conclusion Gratitude can significantly and positively predict coping strategies both directly and indirectly. This study delves into the complex relationship between gratitude and coping strategies, deepening our understanding of this dynamic. Schools and families should prioritize strengthening children's gratitude education and nurturing their confidence and self-esteem to help them cultivate a positive mindset and engage in positive prosocial behaviors.
A 26 years old primigravida woman presented with Abdominal cutaneous entrapment syndrome: a case report
Authors: Berhanu Melaku Tsediew , Kebede Molla Asnake , Tessfaw Adamu Tigabu , Tekle Alemayehu Beharu , Birhanu Anteneh Messele , Deresa Meron Teka 
Published: September 2024

Abstract

Background: Abdominal cutaneous nerve entrapment syndrome (ACNES) is characterized by severe, mostly refractory, chronic pain due to the entrapment of the cutaneous branches of the lower torso intercostal nerves at the lower edge of the rectus abdominis muscle. ACNES is rare compared to other pregnancy-related peripheral neuropathies and is often overlooked as a differential diagnosis for abdominal pain, despite the diagnosis relying primarily on patient history and physical examination. Emergency physicians and other medical personnel's lack of exposure to such cases results in unnecessary laboratory requests, repeated visits, and increased fear and tension for the patient.
Case presentation: A 26-year-old primigravida woman on her second trimester of pregnancy presented to our Emergency department with persistent localized right upper quadrant abdominal pain. Despite repeated visit to the nearby hospital, no diagnosis was settled and the pain persisted. At our ED after a thorough history, physical examination and diagnostic test no abnormality was found. Finally Abdominal cutaneous nerve entrapment syndrome (ACNES) was considered and a mixture of 1 ml 2% lidocaine with adrenaline and 1 ml dexamethasone (4 mg) was infiltrated into the fascial plane in a fanning fashion into the most tender area using a modified technique and the patient reported significant improvement in pain.
Conclusion: Abdominal cutaneous nerve entrapment syndrome (ACNES) is a cause of abdominal pain in pregnancy that is often overlooked. The objective of this study is to describe a rare case of ACNES in a 26-year-old primigravida woman who presented to a low-resource emergency department to assist patient management.
Clinical efficacy of arthroscopic calcium sulfate loaded with vancomycin and implanted to treat postoperative infection after anterior cruciate ligament reconstruction
Authors: Zhou Peng , Zhao ZhengRong , Liu Yang , Zhao MaoSheng , Li ZhiGang , Li ShenSong , Zhang Peng 
Published: September 2024

Abstract

Purpose
To evaluate the efficacy of vancomycin-loaded calcium sulfate for treating postoperative infection after anterior cruciate ligament (ACL) reconstruction, provide a foundation for early diagnosis and treatment of postoperative infection of the anterior cruciate ligament.
Methods
Between September 2015 and September 2021, 34 patients with postoperative ACL infection received treatment. The infected patients were divided into calcium sulfate group and arthroscopic cleaning group. The blood routine chemistry, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were followed up at 1, 2, and 3 weeks postsurgically; knee mobility and visual analog scale (VAS) scores were evaluated at 6 weeks postsurgically; and the knee stability (KT-2000), Lysholm scores, the International Knee Documentation Committee (IKDC) scores, and Tegner scores were followed up at 2 years postsurgically.
Results
The knee range of motion and VAS score of both groups of patients improved significantly at 6 weeks postsurgically compared to presurgically (P < 0.05). Seven patients in the arthroscopic cleaning group still did not achieve the normal knee range of motion after 6 weeks, and four of them underwent manual release surgery under general anesthesia again. There was a significant improvement in knee joint stability, Lysholm scores, IKDC scores, and Tegner scores between the two groups of patients at the 2-year follow-up (P < 0.05). The Lysholm score and IKDC score of the calcium sulfate group were better than those of the arthroscopic cleaning group, and the differences between the groups were statistically significant (P < 0.05). Between the two groups, there was no significant difference in knee joint stability or Tegner score (P > 0.05).
Conclusions
Arthroscopic debridement combined with vancomycin-loaded calcium sulfate antibacterial particles in intra-articular filling can reduce the incidence of knee joint adhesion in ACL reconstruction patients with infections and has good therapeutic efficacy, making it worthy of clinical application.
Level of evidence:
Level III.
Synthesis of Polyacrylamide Nanomicrospheres Modified with a Reactive Carbamate Surfactant for Efficient Profile Control and Plugging
Authors: Yang Wenwen , Lai Xiaojuan , Wang Lei , Shi Huaqiang , Li Haibin , Chen Jiali , Wen Xin , Li Yulong , Song Xiaojiang , Wang Wenfei 
Published: September 2024

Abstract

A carbamate surfactant was synthesized using octadecanol polyoxyethylene ether(AEO) and isocyanatoethyl methacrylate(IEM) as functional monomers. Subsequently, active-carbamate-surfactant-modified PER nanomicrospheres were prepared through two-phase aqueous dispersion polymerization, utilizing acrylamide (AM), 2-acrylamido-2-methylpropanesulfonic acid (AMPS), and ethylene glycol dimethacrylate (EGDMA) as raw materials. The microstructures and properties of the nanomicrospheres were characterized and examined using infrared spectroscopy, nanolaser particle size analysis, thermogravimetric analysis, scanning electron microscopy, rheometry, rotating drop ultra-low interfacial tensiometry, and core-driven experiments. The results revealed that the synthesized PER nanomicrospheres exhibit a uniform particle size distribution, with an average particle size of 336 nm. Furthermore, the nanomicrospheres exhibit a thermal decomposition temperature of 278℃, demonstrating good thermal stability. The nanomicrospheres also exhibit favorable expansion and viscoelastic properties. Upon the injection of 3wt.% of the PER nanomicrospheres into a non-homogeneous core, the blocking rate (η) reaches 90.32%, while the recovery rate increases by 30.2%. This improvement is attributed to the unique structural design of the nanomicrospheres, allowing them to form a thin film at the three-phase oil-water-rock interface and promoting oil emulsification and stripping. Overall, the PER nanomicrospheres effectively control fluid dynamics within reservoirs, mitigate the loss of oil and gas resources, enhance the economic benefits of oil and gas fields, and thus demonstrate good application prospects.
Association between human blood metabolome and risk of myocarditis: a Mendelian randomization study
Authors: Wang Ziyi , Tian Haonan , Wang Jun 
Published: September 2024

Abstract

Objective
Myocarditis is a common disease of the cardiovascular and immune systems, but the relationship between relevant metabolites in the blood and the risk of myocarditis has not been established. To identify biometabolic markers in myocarditis blood, we performed a two-sample MR study.
Methods
MR preliminary analysis: based mainly on the results of IVW, supplemented by MR-Egger, weighted median, and weighted mode for FDR multiple correction; removal of confounders: screened on the GWAS Catalog website; sensitivity analyses: Cochrane Q-test, Egger regression, MR- PRESSO, scatterplot, funnel plot, forest plot; Genetic and directional analysis: co-localization analysis, steiger test; Replicative and Meta-analysis: meta-analysis by extracting the same ending GWAS from another database.
Results
MR analysis identified significant correlations after FDR for 5 metabolic biomarkers (P < 0.05). Four known metabolites: kynurenine, 1-stearoyl-GPE (18:0), Deoxycarnitine, 5-acetylamino-6-formylamino-3-methyluracil with one unknown metabolite: X-25422. Among them, kynurenine (OR = 1.441, 95%CI = 1.089–1.906, P = 0.018) and 1-stearoyl-GPE (18:0) (OR = 1.263, 95%CI = 1.029–1.550, P = 0.029) were risk factors for myocarditis, Deoxycarnitine (OR = 0.813, 95%CI = 0.676–0.979, P = 0.029), 5-acetylamino-6-formylamino-3-methyluracil (OR = 0.864, 95%CI = 0.775–0.962, P = 0.018) and X-25422 (OR = 0.721, 95%CI = 0.587–0.886, P = 0.009) were protective factors against myocarditis. There was no heterogeneity, horizontal pleiotropy, or sensitivity (P < 0.05), no shared genetic factors between exposure and outcome, and the causality was in the right direction. Meta-analysis results again identified five metabolites causally related to myocarditis (I2 < 50%, P < 0.05).
Conclusion
This study identified a causal relationship between five circulating metabolites and myocarditis, and Kynurenine, 1-stearoyl-GPE (18:0), Deoxycarnitine, X-25422, and 5-acetylamino-6-formylamino-3-methyluracil may be as potential drug targets for myocarditis, providing a theoretical basis for the prevention, diagnosis, and treatment of myocarditis.
Evaluating Diagnosis Strategy of Sarcopenia in Chinese Community Older People according to the 2019 Asian Working Group guideline: A Cross-Sectional Study
Authors: Yan Huamei , Chai Yongli , Zhang Yujie , Rong Jiaqi , Zhao Ye , Yuan Weian 
Published: September 2024

Abstract

Background
Most diagnostic studies of sarcopenia in Asian areas follow the 2019 Asia Working Group for Sarcopenia (AWGS) guideline. The guideline proposed separated diagnosis strategies for community vs hospital for difficulty of measuring muscle mass in community settings. Evaluation the whole diagnosis process together with screening instruments in community preventive service setting is serious needed.
Methods
The study is a cross-sectional study. Questionnaire survey was done to evaluate SARC-F and SARC-CalF. Calf circumference(CC), Handgrip strength, gait speed and bioelectrical impedance analysis (BIA) were measured. Four scenarios about different diagnosis strategies were simulated, the sensitivity, specificity and AUC of ROC curve were calculated to evaluate the diagnostic accuracy.
Results
A total of 2453 participants were included. The sarcopenia prevalence was 14.1%, separately 15.4% and 13.1% for male and female. According to the diagnosis procedure of community, in case-finding stage, when using CC, SARC-CalF and SARC-F alone or combined three instruments, the sensitivities were separately 0.84,0.23,0.07 and 0.86, the specificities were separately 0.58,0.93,0.99 and 0.57, the AUCs of ROC curve were 0.710,0.581,0.530 and 0.717 respectively. Using CC and combined situations showed acceptable sensitivity and AUC, but SARC-F or SARC-CalF alone had missed most of sarcopenia. In assessment stage, handgrip strength test was added to those positive people in case-finding stage. the sensitivities were 0.61,0.17,0.06 and 0.63 respectively, the specificities were 0.92,0.98,0.99 and 0.92 respectively, the AUCs of ROC curve were 0.768,0.575,0.523 and 0.776. The sensitivity dropped quickly. In diagnosis stage, measurement of BIA and gait speed were added to those positive people in assessment stage, the sensitivities were 0.61,0.17,0.06 and 0.63, the specificities were all 1.00, the AUCs were 0.806,0.587,0.530 and 0.816. For CC, when cut-offs including critical value would extremely improve sensitivity and AUC of ROC curve.
Conclusions
Diagnosing sarcopenia in community, using SARC-F or SARC-CalF alone should not be recommended in case-finding stage, however, using CC and including critical value of cut-offs are more appropriate. In assessment stage, combined using muscle strength and physical performance rather than choosing one are recommended to avoid sharp reduce in sensitivity.
Cultural Competence and Associated Factors Among Nurses in Ethiopia: A systemic review and Meta-analysis
Authors: Wudu Muluken Amare , Wondifraw Endalik Birrie , Getaneh Fekadeselassie Belege , Bekalu Yemane Eshetu , Birhanu Tarikua Afework 
Published: September 2024

Abstract

Background
Despite constituting three-quarters of the healthcare workforce and being frontline providers of extended care to patients and their families, there is no nationally representative data on cultural competence among nurses in Ethiopia. Therefore, this systematic review was conducted to assess cultural competence and its associated factors among nurses in Ethiopia.
Methods
A systematic review and meta-analysis adhering to the PRISMA guidelines was conducted. The PubMed, Scopus, Google Scholar, and EMBASE databases were searched to identify relevant studies. A Šidák–Jonkman random-effects model was employed to calculate the pooled mean score. Heterogeneity among studies was assessed using Cochrane's Q-test and the I² statistic. Funnel plots and Egger's test were used to assess publication bias. The pooled mean score and meta-regression analysis were performed using STATA 17.
Results
A comprehensive analysis of 643 articles yielded six studies involving 2,344 nurses for inclusion. The pooled mean cultural competence score among Ethiopian nurses was 2.79 (95% CI: 2.25, 3.3). Key factors associated with cultural competence included health institution level (β = 2.28; 95% CI: 1.92–2.87; I2 = 0.00%), experience in caring for diverse patients (β = 1.34; 95% CI: 1.1–1.64; I2 = 42.37%), and educational level (β = 1.3; 95% CI: 1.01–2.23; I2 = 0.00%).
Conclusion
The level of cultural competence among nurses was found to be moderate, indicating a substantial need for improvement to achieve the standards of culturally competent nursing care. This study revealed that health institution level, experience in caring for diverse patients, and educational level were associated with nurses' cultural competence. Policymakers prioritize initiatives aimed at enhancing cultural competence among nurses working in lower-level health institutions and within nursing programs at technical and vocational levels.