bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nostalgia and the City: Urdushahr āshobpoetry in the aftermath of 1857
Authors: TIGNOL EVE 
Published: September 2017

AbstractAfter the Uprising of 1857, many poets from north Indian cities resorted to the Urdu nostalgic genre ofshahr āshobto recall mournfully pre-colonial urban landscapes and articulate emotional and poetic narratives of loss. This article proposes to open new perspectives for the historical study of collective memory and trauma among Urdu-speakingashrāfin the nineteenth century by looking at one collection of such poems entitled ‘The Lament for Delhi (Fuġhān-e Dehlī)’ (1863), which has recently started to attract the attention of historians. Although scholarship has generally emphasised the continuity of these poems with theshahr āshobtradition, this article re-assesses this body of texts through a careful analysis of their main literary motifs and highlights their originality and divergence from previousshahr āshobs. Beyond the stereotypical, the poems of ‘The Lament for Delhi’ both construct 1857 as cultural trauma through the use of powerful literary devices and the performance of collective grief as well as re-channel memory and melancholy into the urban landscape by emphasising its materiality and reinvesting it with new meanings and stakes. This paper more broadly underlines the importance of this under-studied source to understand the impact of 1857 on the imaginary of Urdu-speakingashrāfand on the cultural and social history of colonial India.
Ruralising the City: Migration and Viraha in Translocal Nepal
Authors: STIRR ANNA 
Published: September 2017

AbstractThroughout the history of movement between country and city in the Nepali-speaking areas of the Indian subcontinent, musical links between cities and the rural hills have integrated emotional associations with rural hill life into the fabric of city life. Songs in the thematic genre ofviraha– longing and the pain of separation – articulate lyrical and musical tropes that have come to characterise the experience of moving between hill villages, cities, and back again. This article explores over a century of Nepali-languagevirahasongs related to labour migration, arguing that as these songs take root in translocal publics crossing urban-rural divides, they contribute to an ruralisation of social and emotional life in the cities.
Breast cancer risk factors in relation to estrogen receptor, progesterone receptor, insulin-like growth factor-1 receptor, and Ki67 expression in normal breast tissue
Authors: Oh Hannah , Eliassen A. Heather , Beck Andrew H. , Rosner Bernard , Schnitt Stuart J. , Collins Laura C. , Connolly James L. , Montaser-Kouhsari Laleh , Willett Walter C. , Tamimi Rulla M. 
Published: September 2017

AbstractStudies have suggested that hormone receptor and Ki67 expression in normal breast tissue are associated with subsequent breast cancer risk. We examined the associations of breast cancer risk factors with estrogen receptor (ER), progesterone receptor (PR), insulin-like growth factor-1 receptor (IGF-1R), and Ki67 expression in normal breast tissue. This analysis included 388 women with benign breast disease (ages 17–67 years) in the Nurses’ Health Studies. Immunohistochemical staining was performed on tissue microarrays constructed from benign biopsies containing normal breast epithelium and scored as the percentage of epithelial cells that were positively stained. Ordinal logistic regression (outcomes in tertiles), adjusting for age and potential confounders, was performed to estimate odds ratios (OR) and 95% confidence intervals (CI) for the associations with risk factors. Alcohol consumption was positively associated (≥2.5 vs.<0.4 drink/wk: OR = 2.69, 95% CI = 1.26–5.75, p-trend = 0.008) and breastfeeding was inversely associated (≥6 months vs. never: OR = 0.11, 95% CI = 0.04–0.35, p-trend = 0.0003) with ER expression. Height (≥66 vs.<64 inches: OR = 2.50, 95% CI = 1.34–4.67, p-trend = 0.005) and BMI at age 18 (≥22 vs.<20 kg/m2: OR = 2.33, 95% CI = 1.18–4.62, p-trend = 0.01) were positively associated with PR expression. Body size at age 5–10 years was inversely associated with Ki67 (Level ≥ 2.5 vs. 1: OR = 0.55, 95% CI = 0.30–1.01, p-trend = 0.03). Premenopausal BMI (≥25 vs.<20 kg/m2) was positively associated with cytoplasmic IGF-1R (OR = 5.06, 95% CI = 1.17–21.8, p-trend = 0.04). Our data suggest that anthropometrics, breastfeeding, and alcohol intake may influence the molecular characteristics of normal breast tissue, elucidating the mechanisms by which these risk factors operate. However, larger studies are required to confirm these results.
Research on flexible display at Ulsan National Institute of Science and Technology
Authors: Park Jihun , Heo Sanghyun , Park Kibog , Song Myoung Hoon , Kim Ju-Young , Kyung Gyouhyung , Ruoff Rodney Scott , Park Jang-Ung , Bien Franklin 
Published: September 2017

AbstractDisplays represent information visually, so they have become the fundamental building block to visualize the data of current electronics including smartphones. Recently, electronics have been advanced toward flexible and wearable electronics that can be bent, folded, or stretched while maintaining their performance under various deformations. Here, recent advances in research to demonstrate flexible and wearable displays are reviewed. We introduce these results by dividing them into several categories according to the components of the display: active-matrix backplane, touch screen panel, light sources, integrated circuit for fingerprint touch screen panel, and characterization tests; and we also present mechanical tests in nano-meter scale and visual ergonomics research.
Investigation of Interfacial Layer for Ultrasonic Spot Welded Aluminum to Copper Joints
Authors: Zhang Zijiao , Wang Kaifeng , Li Jingjing , Yu Qian , Cai Wayne 
Published: September 2017

AbstractThe bonding formation for ultrasonic welding of dissimilar metals has been shrouded in mystery because of the complex thermomechanical behavior at the bonding interface. We investigated the microstructure and phases at the bonding interface of ultrasonically welded aluminum to copper joints using transmission electron microscopy, and found a ~10 nm thick transition layer composed of amorphous phase and nanocrystallines, which was believed to form the bonding between these two metals in addition to mechanical interlocking observed at a larger scale. Interdiffusion of parent elements (i.e. Al and Cu) was noticed in the amorphous phase, which was mainly driven by plastic deformation in solid state introduced by ultrasonic vibration. High densities of dislocations and stacking faults were also observed in the parent metals close to the transition layer, confirming the effects of severe plastic deformation.
Pain outside the body: defensive peripersonal space deformation in trigeminal neuralgia
Authors: Bufacchi R. J. , Sambo C. F. , Di Stefano G. , Cruccu G. , Iannetti G. D. 
Published: September 2017

AbstractPerception of space has been guiding effective therapeutic interventions in a number of unilateral chronic pain conditions. However little is known about how trigeminal neuralgia (TN), a condition in which trigeminal stimulation triggers paroxysmal facial pain, affects defensive peripersonal space (DPPS), the portion of space surrounding the body within which defensive responses are enhanced. Given that TN is unilateral, in TN patients the DPPS of the face might not be horizontally symmetric as in pain-free individuals, but instead larger around the affected side. We tested this a priori hypothesis by measuring the proximity-dependent modulation of the hand-blink reflex. Stimuli delivered to the hand ipsilateral to TN elicited a stronger blink, particularly when it was measured from the eye ipsilateral to TN and the hand was closer to the face. Geometric modelling revealed (1) that DPPS was larger on the side of space ipsilateral to TN, and (2) this asymmetry was consequent to an increased estimated potential of sensory events to cause harm when they occur ipsilaterally to TN. These observations demonstrate that neural mechanisms underlying body protection in TN are adjusted to reduce the likelihood that external events evoke the painful paroxysm typical of this condition.
Human in vitro Model Reveals the Effects of Collagen Cross-linking on Keratoconus Pathogenesis
Authors: Sharif Rabab , Hjortdal Jesper , Sejersen Henrik , Frank Garett , Karamichos Dimitrios 
Published: September 2017

AbstractKeratoconus (KC) is a corneal thinning disorder that leads to severe vision impairment As opposed to corneal transplantation; corneal collagen crosslinking (CXL) is a relatively non-invasive procedure that leads to an increase in corneal stiffness. In order to evaluate the effect of CXL on human corneal stromal cells in vitro, we developed a 3-D in vitro CXL model, using primary Human corneal fibroblasts (HCFs) from healthy patients and Human Keratoconus fibroblasts (HKCs) from KC patients. Cells were plated on transwell polycarbonate membranes and stimulated by a stable vitamin C. CXL was performed using a mixed riboflavin 0.1% PBS solution followed by UVA irradiation. Our data revealed no significant apoptosis in either HCFs or HKCs following CXL. However, corneal fibrosis markers, Collagen III and α-smooth muscle actin, were significantly downregulated in CXL HKCs. Furthermore, a significant downregulation was seen in SMAD3, SMAD7, and phosphorylated SMADs -2 and -3 expression in CXL HKCs, contrary to a significant upregulation in both SMAD2 and Lysyl oxidase expression, compared to HCFs. Our novel 3-D in vitro model can be utilized to determine the cellular and molecular effects on the human corneal stroma post CXL, and promises to establish optimized treatment modalities in patients with KC.
Reconstructing human population history from dental phenotypes
Authors: Rathmann Hannes , Reyes-Centeno Hugo , Ghirotto Silvia , Creanza Nicole , Hanihara Tsunehiko , Harvati Katerina 
Published: September 2017

AbstractDental phenotypic data are often used to reconstruct biological relatedness among past human groups. Teeth are an important data source because they are generally well preserved in the archaeological and fossil record, even when associated skeletal and DNA preservation is poor. Furthermore, tooth form is considered to be highly heritable and selectively neutral; thus, teeth are assumed to be an excellent proxy for neutral genetic data when none are available. However, to our knowledge, no study to date has systematically tested the assumption of genetic neutrality of dental morphological features on a global scale. Therefore, for the first time, this study quantifies the correlation of biological affinities between worldwide modern human populations, derived independently from dental phenotypes and neutral genetic markers. We show that population relationship measures based on dental morphology are significantly correlated with those based on neutral genetic data (on averager = 0.574,p < 0.001). This relatively strong correlation validates tooth form as a proxy for neutral genomic markers. Nonetheless, we suggest caution in reconstructions of population affinities based on dental data alone because only part of the dental morphological variation among populations can be explained in terms of neutral genetic differences.
Omega-6 and omega-3 oxylipins are implicated in soybean oil-induced obesity in mice
Authors: Deol Poonamjot , Fahrmann Johannes , Yang Jun , Evans Jane R. , Rizo Antonia , Grapov Dmitry , Salemi Michelle , Wanichthanarak Kwanjeera , Fiehn Oliver , Phinney Brett , Hammock Bruce D. , Sladek Frances M. 
Published: September 2017

AbstractSoybean oil consumption is increasing worldwide and parallels a rise in obesity. Rich in unsaturated fats, especially linoleic acid, soybean oil is assumed to be healthy, and yet it induces obesity, diabetes, insulin resistance, and fatty liver in mice. Here, we show that the genetically modified soybean oil Plenish, which came on the U.S. market in 2014 and is low in linoleic acid, induces less obesity than conventional soybean oil in C57BL/6 male mice. Proteomic analysis of the liver reveals global differences in hepatic proteins when comparing diets rich in the two soybean oils, coconut oil, and a low-fat diet. Metabolomic analysis of the liver and plasma shows a positive correlation between obesity and hepatic C18 oxylipin metabolites of omega-6 (ω6) and omega-3 (ω3) fatty acids (linoleic and α-linolenic acid, respectively) in the cytochrome P450/soluble epoxide hydrolase pathway. While Plenish induced less insulin resistance than conventional soybean oil, it resulted in hepatomegaly and liver dysfunction as did olive oil, which has a similar fatty acid composition. These results implicate a new class of compounds in diet-induced obesity–C18 epoxide and diol oxylipins.
Single-cell analysis reveals sexually dimorphic repertoires of Interferon-γ and IL-17A producing T cells in salivary glands of Sjögren’s syndrome mice
Authors: Wanchoo Arun , Voigt Alexandria , Sukumaran Sukesh , Stewart Carol M. , Bhattacharya Indraneel , Nguyen Cuong Q. 
Published: September 2017

AbstractThe development of Sjögren’s syndrome (SjS) is a dynamic and temporal process with a female predilection. Following the initial influx of immune cells, T cell clusters develop, accelerating the pathology in the salivary glands. Proinflammatory cytokines, IFN-γ and IL-17A, produced by T cells contribute synergistically to the disease. In this study, we examined the sexual dimorphism in cellular infiltrates of the salivary glands by using functional single-cell microengraving analysis. Using high-throughput sequencing, we investigated the clonal diversity of the T cell receptors (TCRs) of infiltrating IFN-γ and IL-17A-producing T cells in male and female SjS-susceptible (SjSs) C57BL/6.NOD-Aec1Aec2mice. There were elevated frequencies of IFN-γ and IL-17A-producing effector T cell populations in female SjSSmice compared to male SjSSmice. MEME analysis shows high frequency and unique, sexually dimorphic motifs in the TCR hypervariable regions in the SjSSmice. Male mice selected for TRAV8/TRAJ52 (CATDLNTGANTGKLTFG) TCR genes in Th1 cells and TRBV16/(TRBD1/2)TRBJ1-7 (CGGKRRLESIFR) in Th1 and Th17 cells. Female SjSSmice selected for TRAV8/TRAJ52 (CATDLNTGANTGKLTFG), TRAV13D-2/TRAJ23 (CVYLEHHFE), and TRBV23/(TRBD2)TRBJ2-2 (CRKLHSCATCALNFL) in Th1 cells. These findings suggest that there is an elevated prevalence of pathogenic effector T cells in the glands with a sexually dimorphic selection bias of TCR repertoires.
A proposed method to measure weak magnetic field based on a hybrid optomechanical system
Authors: Liu Zeng-Xing , Wang Bao , Kong Cui , Si Liu-Gang , Xiong Hao , Wu Ying 
Published: September 2017

AbstractOptomechanical systems have long been considered in the field of precision measurement. In this work, measurement of weak magnetic field in a hybrid optomechanical system is discussed. In contrast to conventional measurements based on detecting the change of magnetic flux, our scheme presents an alternative way to measure the magnetic field with a precision of 0.1 nT. We show that the effective cavity resonance frequency will be revised due to the electromagnetic interactions. Therefore, a resonance valley in the transmission spectrum of the probe field will shift in the presence of the magnetic field, and the width of an asymmetric transparency in the optomechanically induced transparency (OMIT) shows a strong dependence on the magnetic field strength. Our results may have potential application for achieving high precision measurement of the magnetic field.
Functional relationship of AtABCG21 and AtABCG22 in stomatal regulation
Authors: Kuromori Takashi , Sugimoto Eriko , Ohiraki Haruka , Yamaguchi-Shinozaki Kazuko , Shinozaki Kazuo 
Published: September 2017

AbstractStomatal regulation is important for water transpiration from plants. Stomatal opening and closing are controlled by many transporter proteins in guard cells. AtABCG22 is a member of the ATP-binding cassette (ABC) transporters and is a stomatal regulator; however, the function of AtABCG22 has not yet been determined fully, although a mutant phenotype included a significant effect on stomatal status. Here, we further investigated the function of the AtABCG22 gene and its functional relationships with other subfamily genes. Among close family members, we found a functional relationship of stomatal phenotypes with AtABCG21, which is also expressed specifically in guard cells. Based on an analysis of double mutants, adding the atabcg21 mutation to atabcg22 mutant partially suppressed the open-stomata phenotype of atabcg22. Multiple-mutant analyses indicated that this suppression was independent of abscisic acid signaling in guard cells. We also found that atabcg22 mutant showed a unique time course-dependent phenotype, being defective in maintenance of stomatal status after initial stomatal opening elicited by light signaling. The function of AtABCG22 and its relationship with AtABCG21 in stomatal regulation are considered.
Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis
Authors: Fakouri Nima Borhan , Durhuus Jon Ambæk , Regnell Christine Elisabeth , Angleys Maria , Desler Claus , Hasan-Olive Md Mahdi , Martín-Pardillos Ana , Tsaalbi-Shtylik Anastasia , Thomsen Kirsten , Lauritzen Martin , Bohr Vilhelm A. , de Wind Niels , Bergersen Linda Hildegard , Rasmussen Lene Juel 
Published: September 2017

AbstractNucleic acids, which constitute the genetic material of all organisms, are continuously exposed to endogenous and exogenous damaging agents, representing a significant challenge to genome stability and genome integrity over the life of a cell or organism. Unrepaired DNA lesions, such as single- and double-stranded DNA breaks (SSBs and DSBs), and single-stranded gaps can block progression of the DNA replication fork, causing replicative stress and/or cell cycle arrest. However, translesion synthesis (TLS) DNA polymerases, such as Rev1, have the ability to bypass some DNA lesions, which can circumvent the process leading to replication fork arrest and minimize replicative stress. Here, we show that Rev1-deficiency in mouse embryo fibroblasts or mouse liver tissue is associated with replicative stress and mitochondrial dysfunction. In addition, Rev1-deficiency is associated with high poly(ADP) ribose polymerase 1 (PARP1) activity, low endogenous NAD+, low expression of SIRT1 and PGC1α and low adenosine monophosphate (AMP)-activated kinase (AMPK) activity. We conclude that replication stress via Rev1-deficiency contributes to metabolic stress caused by compromized mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis.
HDL cholesterol efflux normalised to apoA-I is associated with future development of type 2 diabetes: from the CORDIOPREV trial
Authors: Blanco-Rojo Ruth , Perez-Martinez Pablo , Lopez-Moreno Javier , Martinez-Botas Javier , Delgado-Lista Javier , van-Ommen Ben , Yubero-Serrano Elena , Camargo Antonio , Ordovas Jose M. , Perez-Jimenez Francisco , Gomez-Coronado Diego , Lopez-Miranda Jose 
Published: September 2017

AbstractThis prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years of follow-up. Cholesterol efflux was quantified by incubation of cholesterol-loaded THP-1 cells with the participants’ apoB-depleted plasma. Disposition index was estimated as beta-cell function indicator. During follow-up 106 individuals progressed to T2DM. The cholesterol efflux/apoA-1 ratio was inversely associated with T2DM development independently of traditional risk factors (model-1, OR: 0.647, 95%CI: 0.495–0.846), and after additional adjustment for glycaemic parameters (model-2, OR: 0.670, 95%CI: 0.511–0.878). When cumulative incidence of diabetes was analysed by quartiles of cholesterol efflux/apoA-I, incidence of T2DM was reduced by 54% in subjects who were in the higher cholesterol efflux/apoA-I quartile compared to subjects in the lowest quartile (p = 0.018 and p = 0.042 for model-1 and 2). Moreover, participants who were in the higher cholesterol efflux/apoA-I presented significantly higher disposition index (β = 0.056, SE = 0.026; p = 0.035). In conclusion, HDL-cholesterol efflux normalised to apoA-I was inversely associated with T2DM development in cardiovascular patients. This association was independent of several T2DM risk factors, and may be related to a preserved beta-cell function.
Schwann cells promote post-traumatic nerve inflammation and neuropathic pain through MHC class II
Authors: Hartlehnert Maike , Derksen Angelika , Hagenacker Tim , Kindermann David , Schäfers Maria , Pawlak Mathias , Kieseier Bernd C. , Meyer zu Horste Gerd 
Published: September 2017

AbstractThe activation of T helper cells requires antigens to be exposed on the surface of antigen presenting cells (APCs) via MHC class II (MHC-II) molecules. Expression of MHC-II is generally limited to professional APCs, but other cell types can express MHC-II under inflammatory conditions. However, the importance of these conditional APCs is unknown. We and others have previously shown that Schwann cells are potentially conditional APCs, but the functional relevance of MHC-II expression by Schwann cells has not been studied in vivo. Here, we conditionally deleted the MHC-II β-chain from myelinating Schwann cells in mice and investigated how this influenced post-traumatic intraneural inflammation and neuropathic pain using the chronic constriction injury (CCI) model. We demonstrate that deletion of MHC-II in myelinating Schwann cells reduces thermal hyperalgesia and, to a lesser extent, also diminishes mechanical allodynia in CCI in female mice. This was accompanied by a reduction of intraneural CD4+ T cells and greater preservation of preferentially large-caliber axons. Activation of T helper cells by MHC-II on Schwann cells thus promotes post-traumatic axonal loss and neuropathic pain. Hence, we provide experimental evidence that Schwann cells gain antigen-presenting function in vivo and modulate local immune responses and diseases in the peripheral nerves.
Pore formation in lipid membrane II: Energy landscape under external stress
Authors: Akimov Sergey A. , Volynsky Pavel E. , Galimzyanov Timur R. , Kuzmin Peter I. , Pavlov Konstantin V. , Batishchev Oleg V. 
Published: September 2017

AbstractLipid membranes are extremely stable envelopes allowing cells to survive in various environments and to maintain desired internal composition. Membrane permeation through formation of transversal pores requires substantial external stress. Practically, pores are usually formed by application of lateral tension or transmembrane voltage. Using the same approach as was used for obtaining continuous trajectory of pore formation in the stress-less membrane in the previous article, we now consider the process of pore formation under the external stress. The waiting time to pore formation proved a non-monotonous function of the lateral tension, dropping from infinity at zero tension to a minimum at the tension of several millinewtons per meter. Transmembrane voltage, on the contrary, caused the waiting time to decrease monotonously. Analysis of pore formation trajectories for several lipid species with different spontaneous curvatures and elastic moduli under various external conditions provided instrumental insights into the mechanisms underlying some experimentally observed phenomena.