bluuebunny/crossref_metadata_2025_split huggingface dataset:
Risk Factors Associated With Grade 3 Pivot Shift After Acute Anterior Cruciate Ligament Injuries
Authors: Song Guan-yang , Zhang Hui , Wang Qian-qian , Zhang Jin , Li Yue , Feng Hua 
Published: December 2015

Background: Recent literature has demonstrated that involvement in pivoting sports at the time of injury, increased posterior-inferior tibial slope (PITS), anterolateral capsular ligament (ALCL) disruptions, and combined lateral meniscal lesions all contribute to a higher grade of pivot shift after acute anterior cruciate ligament (ACL) injuries. Purpose: To identify risk factors associated with grade 3 pivot shift after acute ACL injuries. Study Design: Case-control study; Level of evidence, 3. Methods: A database of patients undergoing primary ACL reconstruction from 2009 to 2015 after acute ACL injuries was retrospectively reviewed. A total of 30 patients (30 knees) with grade 3 pivot shift were identified as the study group. Moreover, 30 patients (30 knees) with grade 1 and 30 patients (30 knees) with grade 2 pivot shift were randomly chosen as the 2 control groups. All pivot-shift tests were performed with the patients under anesthesia. Predictors of grade 3 pivot shift that were explored included patient age, sex, time from injury to surgery, pivoting sports involvement at the time of injury, lateral PITS, medial PITS, ALCL disruptions, preoperative KT-1000 arthrometer side-to-side difference, and combined lateral or medial meniscal lesions. Comparisons were performed between the study group and the 2 control groups. Univariable and multivariable logistic regressions were used to identify independent risk factors that were associated with grade 3 pivot shift. Results: Univariable and multivariable logistic regressions between the study group and the 2 control groups showed that pivoting sports involvement at the time of injury (odds ratio1 [OR1; grade 3 vs grade 1 pivot shift with grade 1 = reference], 11.88; 95% CI, 1.94-149.91; OR2 [grade 3 vs grade 2 pivot shift with grade 2 = reference], 3.41; 95% CI, 1.92-22.60), abnormal degree of lateral PITS (OR1, 14.41; 95% CI, 1.69-174.78; OR2, 6.41; 95% CI, 1.48-47.70), ALCL disruptions (OR1, 8.28; 95% CI, 1.71-117.14; OR2, 4.96; 95% CI, 1.07-28.75), and combined lateral meniscal lesions (OR1, 27.56; 95% CI, 5.48-240.52; OR2, 5.83; 95% CI, 1.21-38.56) were independent risk factors of grade 3 pivot shift after acute ACL injuries. Conclusion: For acute ACL injuries, the best set of predictors of grade 3 pivot shift were pivoting sports involvement at the time of injury, abnormal lateral PITS, ALCL disruptions, and combined lateral meniscal lesions. These results may provide additional information for counseling patients on residual laxity and risks for graft rerupture after ACL reconstruction.
Effects of eccentricity and vibration response on high-speed rigid rotor supported by hybrid foil-magnetic bearing
Authors: Jeong Sena , Lee Yong Bok 
Published: December 2015

A hybrid foil-magnetic bearing (HFMB) consists of an air foil bearing (AFB) and an active magnetic bearing (AMB). The HFMB, inherently proposed as a backup bearing for an AMB, has many advantages, such as good controllability and the ability to exhibit preload sharing with the two types of bearings (i.e., the AFB and AMB) in high-speed turbomachinery. However, because the bearing has a limited clearance, the eccentric position of the rotor affects its stability and the reliability parameters of the AFBs such as the initial preload rub. In this study, a rigid rotor supported by an HFMB was operated at speeds of up to 18 kr/min and was tested using a proportional-derivative control algorithm, in order to reduce the vibration amplitude. In addition, to elucidate the effect of the initial eccentric position of the rotor, the control algorithm was started from the initial position of the rotor (X: from –100 to 100 µm and Y: from –80 to 200 µm) using a constant gain value. When the HFMB was active, the magnetic control force was remarkably effective in reducing the subsynchronous vibration of the rotor supported by the HFMB. Eccentricities of 0.2–0.5 corresponded to appropriate rotor positions for the hybrid bearing, and the corresponding load distribution of the AFB was found to be the optimal one. In addition, the proportional-derivative control gain was not very high. The performance of the bearing could be improved further by controlling the eccentricity. An HFMB was tested experimentally, and it was verified that it is possible to determine the effective load carrying capacity for a specific load distribution of the AFB.
Direct Oral Anticoagulants for Very Elderly People With Atrial Fibrillation
Authors: Pasca Samantha , Venturelli Ugo , Bertone Antonella , Barillari Giovanni 
Published: December 2015

Background: Four direct oral anticoagulants (DOACs) have been licensed for the treatment of atrial fibrillation (AF); efficacy and safety have been shown in clinical trials, but its real use in elderly and very elderly people is still unclear. Aim: To evaluate the impact of DOACs in our patients (pts) aged ≥75 years and switched from other treatments. Methods: From September 2013 to May 2015, all consecutive pts aged ≥75 years, males and females, in treatment for AF and switched to DOACs are considered in this study. Follow-up (FU) was scheduled after 3 and 6 months by phone and after 12 months by visit. Results: Two hundred thirty-two pts in treatment for AF were switched to DOACs, among these 143 (61.6%) pts aged ≥75 years (mean age, 81 years). The medium FU was 9.6 months, during which 4 minor bleedings in 4 different pts and 1 clinically relevant nonmajor bleeding were reported, all treated with temporary cessation or reduction in DOACs. Two strokes occurred in pts in treatment with dabigatran 110 mg, both resolved without serious sequelae; 2.8% of pts had nausea, itching, vomiting, or discomfort, half of these returned to acenocumarol, and the remaining switched to other DOAC. Four pts died, but the deaths were not related to anticoagulation. Conclusion: As reported for general people, also in our elderly population, DOACs resulted in a good alternative to old antithrombotic therapies. Efficacy and safety associated with a higher compliance by pts bring these drugs to be the first choice for long-term anticoagulation.
Superoxide anions produced by Streptococcus pyogenes group A-stimulated keratinocytes are responsible for cellular necrosis and bacterial growth inhibition
Authors: Regnier Elodie , Grange Philippe A , Ollagnier Guillaume , Crickx Etienne , Elie Laetitia , Chouzenoux Sandrine , Weill Bernard , Plainvert Céline , Poyart Claire , Batteux Frédéric , Dupin Nicolas 
Published: December 2015

Gram-positive Streptococcus pyogenes (group A Streptococcus or GAS) is a major skin pathogen and interacts with keratinocytes in cutaneous tissues. GAS can cause diverse suppurative and inflammatory infections, such as cellulitis, a common acute bacterial dermo-hypodermitis with a high morbidity. Bacterial isolation yields from the lesions are low despite the strong local inflammation observed, raising numerous questions about the pathogenesis of the infection. Using an in vitro model of GAS-infected keratinocytes, we show that the major ROS produced is the superoxide anion ([Formula: see text]), and that its production is time- and dose-dependent. Using specific modulators of ROS production, we show that [Formula: see text] is mainly synthesized by the cytoplasmic NADPH oxidase. Superoxide anion production leads to keratinocyte necrosis but incomplete inhibition of GAS growth, suggesting that GAS may be partially resistant to the oxidative burst. In conclusion, GAS-stimulated keratinocytes are able to develop an innate immune response based on the production of ROS. This local immune response limits GAS development and induces keratinocyte cell death, resulting in the skin lesions observed in patients with cellulitis.
Regional Differential Genetic Response of Human Articular Cartilage to Impact Injury
Authors: Vernon Lauren L. , Vance Danica D. , Wang Liyong , Rampersaud Evadnie , Vance Jeffery M. , Pericak-Vance Margaret , Huang C.-Y. Charles , Kaplan Lee D. 
Published: December 2015

Objective Normal physiological movement creates different weightbearing zones within a human knee: the medial condyle bearing the highest and the trochlea bearing the lowest weight. Adaptation to different physiological loading conditions results in different tissue and cellular properties within a knee. The objective of this study was to use microarray analysis to examine gene expression differences among three anatomical regions of human knee articular cartilage at baseline and following induction of an acute impact injury. Design Cartilage explants were harvested from 7 cadaveric knees (12 plugs per knee). A drop tower was utilized to introduce injury. Plugs were examined 24 hours after impact for gene expression using microarray. The primary analysis is the comparison of baseline versus impacted samples within each region separately. In addition, pairwise comparisons among the three regions were performed at baseline and after impact. False discovery rate (FDR) was used to evaluate significance of differential gene expression. Results In the comparison of before and after injury, the trochlear had 130 differentially expressed genes (FDR ≤ 0.05) while the condyles had none. In the comparison among regions, smaller sets of differentially expressed genes ( n ≤ 21) were found, with trochlea being more different than the condyles. Most of more frequently expressed genes in trochlea are developmental genes. Conclusions Within the experimental setup of this study, only the trochlea was displaying an acute genetic response on injury. Our data demonstrated the regional-specific response to injury in human articular cartilage.
Thalassemia and sickle cell anemia in Swedish immigrants: Genetic diseases have become global
Authors: Hemminki Kari , Li Xinjun , Försti Asta , Sundquist Jan , Sundquist Kristina 
Published: December 2015

Aims: Some 15% of the Swedish population is born outside Sweden, originating from all continents of the world. Thalassemia and sickle cell anemia constitute the most common inherited recessive disorders globally and they are endemic in areas of Africa and Asia, origins of many immigrants to Sweden. We aimed at investigating the origins of the Swedish sickle cell and thalassemia patients. Methods: Patients were identified using data from the Swedish Hospital Discharge Register since 1987 and from the Outpatient Register since 2001 up to year 2010. Results: A total of 3064 persons were diagnosed with thalassemia. The incidence was highest, 62.9/100,000 for immigrants from Thailand, followed by Iraqis (47.1/100,000); the rate was 0.7/100,000 among those born in Sweden. The total number of sickle cell anemia patients was 584 and the highest rate of 13.0/100,000 was found for Sub-Saharan immigrants. For thalassemia, 363 of the patients were siblings, while for sickle cell anemia, 180 were siblings. Conclusions: The data showed that >90% of sickle cell and thalassemia patients were first- or second-generation immigrants to Sweden and the endemic regions for these were the origins of immigrants with the highest incidence. Global immigration provides global challenges to national health care systems.
Systematic review and network meta-analysis of the relative efficacy and safety of edoxaban versus other nonvitamin K antagonist oral anticoagulants among patients with nonvalvular atrial fibrillation and CHADS2 score ⩾ 2
Authors: Fernandez Maria M , Wang Jianmin , Ye Xin , Kwong Winghan Jacqueline , Sherif Bintu , Hogue Susan , Sherrill Beth 
Published: December 2015

Background: The nonvitamin K antagonist oral anticoagulants pivotal clinical trials for stroke prevention in atrial fibrillation have important differences in trial designs and baseline patient characteristics. Objective: We sought to evaluate the relative efficacy and safety of edoxaban versus other nonvitamin K antagonist oral anticoagulants in the management of stroke prevention in atrial fibrillation by adjusting for differences in baseline stroke risk and the length of follow-up among the four phase 3 randomized controlled trials. Methods: We conducted a systematic literature review of randomized controlled trials evaluating the nonvitamin K antagonist oral anticoagulants for stroke prevention in atrial fibrillation and performed a network meta-analysis using data from ENGAGE AF-TIMI 48, RE-LY, ROCKET-AF, and ARISTOTLE, with warfarin as a common comparator. To adjust for between-trial differences in CHADS2 score and length of follow-up, annualized event rates among patients with CHADS2 score ⩾ 2 were analyzed using a mixed Poisson’s regression model. Results: Once-daily high-dose edoxaban was associated with significant lower major bleeding episodes compared with once-daily rivaroxaban (risk ratio, 0.76; 95% confidence interval, 0.66–0.89), twice-daily dabigatran 150 mg (risk ratio, 0.78; 95% confidence interval, 0.61–0.84), and twice-daily dabigatran 110 mg (risk ratio, 0.83; 95% confidence interval, 0.71–0.98) and similar bleeding risk compared with twice-daily apixaban (risk ratio, 1.08; 95% confidence interval, 0.91–1.28). Risk of stroke and systemic embolism was similar for the high-dose edoxaban and other nonvitamin K antagonist oral anticoagulant regimens. The low-dose edoxaban regimen was associated with a significant lower risk of major bleeding than other nonvitamin K antagonist oral anticoagulants and a significant higher risk of stroke and systemic embolism compared with apixaban and dabigatran 150 mg. Conclusion: Among patients with atrial fibrillation and CHADS2 score ⩾ 2, the high-dose edoxaban regimen may offer similar efficacy to the other nonvitamin K antagonist oral anticoagulants but with a significant major bleeding benefit over rivaroxaban and dabigatran.
An observational study comparing the prototype device with the existing device for the effective visualization of invisible veins in elderly patients in Japan
Authors: Kimori Keiko , Sugama Junko , Nakatani Toshio , Nakayama Kazuya , Miyati Tosiaki , Sanada Hiromi 
Published: December 2015

Objective: To compare the performance on the detection of the invisible veins between our modified prototype device and an existing device in elderly hospitalized patients. Methods: A prospective, cross-sectional, and observational study was performed in the invisible veins in elderly patients. The major variables, skin color near the invisible veins, and diameter and depth of the invisible veins were measured. The vein visualization rate was calculated as the ratio of the visualized veins to the invisible veins by the visualization device. Results: We analyzed 53 invisible veins in the cubital fossa and 56 invisible veins in the forearm in a total of 72 patients (median age, 73 years). The visualization rate for our prototype device was higher than that for an existing device in the cubital fossa and the forearm sites. The visualized veins of the prototype device had a higher intensity ratio than that of an existing device. No significant differences were observed in the body mass index, vein depth, and vein diameter of the visualized veins at the cubital fossa and forearm sites. Conclusion: The prototype surpassed the existing device in visualizing the invisible veins. However, the prototype was unable to visualize all the invisible veins. We need to look for ways to reduce noise and to visualize the invisible veins, and the visualization rate of devices needs to be investigated in further association with the percentage of success with actual intravenous access and locating time to vein.
Self-resolving focal non-ossifying myositis: a poorly known clinical and imaging entity diagnosed with MRI
Authors: Perlepe Vasiliki , Dallaudière Benjamin , Omoumi Patrick , Hristova Lora , Rezzazadeh Afshin , Vande Berg Bruno , Malghem Jacques , Lecouvet Frederic 
Published: December 2015

BackgroundFocal myositis is a rare benign inflammatory pseudotumor, presenting as a painful nodular mass within a muscle, and characterized by spontaneous resolution within weeks.PurposeTo assess the clinical and imaging findings of focal nodular myositis simulating a neoplasm at clinical examination, with no history of trauma.Material and MethodsThis study describes the locations and appearance at ultrasonography (US), computed tomography (CT), and magnetic resonance imaging (MRI) of this condition in a series of five patients.ResultsMRI and US displayed a solid intramuscular “tumor” and suggested a continuum between the proximal and distal muscle fibers that appeared thickened within the nodular lesion, a sign that has been reported in myositis ossificans. MRI showed edema in adjacent muscles and soft tissues, as well as intense enhancement of the mass. Intense vascular flows were seen at Doppler analysis. CT did not reveal the appearance of peripheral ossifications, ruling out the diagnosis of myositis ossificans. In some patients, the diagnosis of sarcoma had been suggested as possible by the radiologist. Imaging follow-up with MRI showed complete resolution of the masses over several weeks, thus avoiding a biopsy; no recurrence was observed at long-term follow-up (more than 24 months).ConclusionThis paper highlights MRI and US findings in focal non-ossifying myositis, and emphasizes the role of MRI in suggesting this diagnosis, leading to the careful follow-up of the lesion until its resolution, and ruling out more aggressive lesions.
Non-contrast-enhanced hepatic MR arteriography with balanced steady-state free-precession and time spatial labeling inversion pulse: optimization of the inversion time at 3 Tesla
Authors: Kawahara Seiya , Isoda Hiroyoshi , Ohno Tsuyoshi , Furuta Akihiro , Togashi Kaori 
Published: December 2015

Background A 3 Tesla (3 T) magnetic resonance (MR) scanner is a promising tool for upper abdominal angiography. However, no report has focused on the contrast behavior of non-contrast-enhanced hepatic MR arteriography at 3 T. Purpose To establish the optimal inversion time (TI) for favorable selective visualization of the hepatic arteries on non-contrast-enhanced MR arteriography with time spatial labeling inversion pulse (Time-SLIP) at 3 T. Material and Methods Twenty-five healthy volunteers were examined using respiratory-triggered three-dimensional balanced steady-state free-precession combined with Time-SLIP. According to the difference in the TI, five image groups (A, B, C, D, and E, from 1200 to 2000 ms, increasing at 200-ms intervals) were performed and compared to detect the optimal TI for hepatic artery visualization. The relative Cv-l (vessel-to-liver contrast) was quantified. For qualitative evaluation, the vessel visualization quality and order of the depicted hepatic artery branches were evaluated. Results In group C (TI of 1600 ms), the Cv-l showed the highest probably due to a favorable balance between the hepatic vessel signal and signal recovery of the surrounding tissue. Regarding qualitative assessment, in group C, the mean image quality score of all hepatic arteries and mean maximal visible order of the hepatic artery branches were the highest. However, there was no significant difference between these results. Conclusion Non-contrast-enhanced hepatic MR arteriography with Time-SLIP at 3 T enabled the selective visualization of hepatic arteries at a TI of 1600 ms with an optimal balance between Cv-l and peripheral hepatic artery visualization.
KIT D816V–mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progression
Authors: Garcia-Montero Andres C. , Jara-Acevedo Maria , Alvarez-Twose Ivan , Teodosio Cristina , Sanchez-Muñoz Laura , Muñiz Carmen , Muñoz-Gonzalez Javier I. , Mayado Andrea , Matito Almudena , Caldas Carolina , Morgado Jose M. , Escribano Luis , Orfao Alberto 
Published: December 2015

Key Points
Acquisition of the KIT D816V mutation in an early pluripotent progenitor cell confers ISM cases a greater risk for disease progression. Despite the early acquisition of the KIT mutation, onset of clinical symptoms of ISM is often delayed to middle adulthood.
Pulmonary alveolar microlithiasis: review of the 1022 cases reported worldwide
Authors: Castellana Giuseppe , Castellana Giorgio , Gentile Mattia , Castellana Roberto , Resta Onofrio 
Published: December 2015

Pulmonary alveolar microlithiasis (PAM) is a rare disease characterised by the widespread intra-alveolar accumulation of minute calculi called microliths. It is caused by mutation of theSLC34A2gene encoding the type IIb sodium phosphate cotransporter in alveolar type II cells. The present study explores the epidemiological, familial, genetic, clinical, diagnostic, radiological and therapeutic aspects with the aim of contributing to a better understanding of this uncommon disease.We searched articles on PAM published up to December 2014 and 544 papers were found, accounting for 1022 cases.PAM is present in all continents and in many nations, in particular in Turkey, China, Japan, India, Italy and the USA. Familiality is frequent. The clinical course is not uniform and the causes of this clinical variability seem to be largely nongenetic. The optimal diagnostic procedure is the association of chest high-resolution computed tomography (HRCT) with bronchoalveolar lavage, but a chest radiograph may suffice in families in which a case has already been diagnosed. Moreover, chest radiography and HRCT allow the classification of the evolutionary phase of the disease and its severity. At present lung transplantation is the only effective therapy. However, better knowledge of the gene responsible offers hope for new therapies.