bluuebunny/crossref_metadata_2025_split huggingface dataset:
MiCOMP
Authors: Ashouri Amir H. , Bignoli Andrea , Palermo Gianluca , Silvano Cristina , Kulkarni Sameer , Cavazos John 
Published: September 2017

Recent compilers offer a vast number of multilayered optimizations targeting different code segments of an application. Choosing among these optimizations can significantly impact the performance of the code being optimized. The selection of the right set of compiler optimizations for a particular code segment is a very hard problem, but finding the best ordering of these optimizations adds further complexity. Finding the best ordering represents a long standing problem in compilation research, named the
phase-ordering
problem. The traditional approach of constructing compiler heuristics to solve this problem simply cannot cope with the enormous complexity of choosing the right ordering of optimizations for every code segment in an application.

This article proposes an automatic optimization framework we call MiCOMP, which <u>Mi</u>tigates the <u>Com</u>piler <u>P</u>hase-ordering problem. We perform phase ordering of the optimizations in LLVM’s highest optimization level using optimization sub-sequences and machine learning. The idea is to cluster the optimization passes of LLVM’s O3 setting into different clusters to predict the speedup of a complete sequence of all the optimization clusters instead of having to deal with the ordering of more than 60 different individual optimizations. The predictive model uses (1) dynamic features, (2) an encoded version of the compiler sequence, and (3) an exploration heuristic to tackle the problem.
Experimental results using the LLVM compiler framework and the Cbench suite show the effectiveness of the proposed clustering and encoding techniques to application-based reordering of passes, while using a number of predictive models. We perform statistical analysis on the results and compare against (1) random iterative compilation, (2) standard optimization levels, and (3) two recent prediction approaches. We show that MiCOMP’s iterative compilation using its sub-sequences can reach an average performance speedup of 1.31 (up to 1.51). Additionally, we demonstrate that MiCOMP’s prediction model outperforms the -O1, -O2, and -O3 optimization levels within using just a few predictions and reduces the prediction error rate down to only 5%. Overall, it achieves 90% of the available speedup by exploring less than 0.001% of the optimization space.
Informality, Class Structure, and Class Identity in Contemporary Argentina
Authors: Elbert Rodolfo 
Published: September 2017

The dynamics of peripheral capitalism in Latin America includes the employment or self-employment of a significant proportion of the working class under informal arrangements. The neoliberal transformations of the 1990s deepened this feature of Latin American labor markets, and it was not reversed during the period of economic growth that followed the collapse of neoliberalism. In this context, sociological debates have focused on the relationship between the formal and the informal fractions of the working class. Examination of the biographical and family linkages between formal and informal workers in Argentina and the effect of these connections on the patterns of class self-identification of individuals shows that lived experience across the informality boundary makes formal workers similar to informal workers in terms of class self-identification. This research provides preliminary evidence that the two kinds of workers belong to the same social class because of the fluidity of the boundary that separates them. Instead of a class cleavage, this boundary is better defined as the separation between fractions of the working class. La dinámica del capitalismo periférico en América Latina implica la informalidad laboral (sea entre trabajadores contratados o autónomos) de una sustancial parte de la clase obrera. Las transformaciones neoliberales de los años noventa profundizaron esta característica de los mercados de trabajo latinoamericanos, y el problema no se revirtió durante el período de crecimiento económico que siguió al colapso del neoliberalismo. En este contexto, los debates sociológicos se han centrado en la relación entre los grupos formales e informales de la clase obrera. Un análisis de los vínculos biográficos y familiares entre los trabajadores formales e informales en Argentina y el efecto de dichas conexiones en los patrones individuales de autoidentificación de clase muestra que la experiencia vivida en los límites de la informalidad hace que los trabajadores formales se consideren similares a los informales en términos de identificación de clase. Esta investigación brinda evidencia preliminar de que los dos tipos de trabajadores pertenecen a la misma clase social.
Radiation Therapy and Esophageal Cancer
Authors: Shridhar Ravi , Almhanna Khaldoun , Meredith Kenneth L. , Biagioli Matthew C. , Chuong Michael D. , Cruz Alex , Hoffe Sarah E. 
Published: September 2017

Background Squamous cell carcinoma and adenocarcinoma account for more than 90% of all esophageal cancer cases. Although the incidence of squamous cell carcinoma has declined, the incidence of adenocarcinoma has risen due to increases in obesity and gastroesophageal reflux disease. Methods The authors examine the role of radiation therapy alone (external beam and brachytherapy) for the management of esophageal cancer or combined with other modalities. The impact on staging and appropriate stratification of patients referred for curative vs palliative intent with modalities is reviewed. The authors also explore the role of emerging radiation technologies. Results Current data show that neoadjuvant chemoradiotherapy followed by surgical resection is the accepted standard of care, with 3-year overall survival rates ranging from 30% to 60%. The benefit of adjuvant radiation therapy is limited to patients with node-positive cancer. The survival benefit of surgical resection after chemoradiotherapy remains controversial. External beam radiation therapy alone results in few long-term survivors and is considered palliative at best. Radiation dose-escalation has failed to improve local control or survival. Brachytherapy can provide better long-term palliation of dysphagia than metal stent placement. Although three-dimensional conformal treatment planning is the accepted standard, the roles of IMRT and proton therapy are evolving and potentially reduce adverse events due to better sparing of normal tissue. Conclusions Future directions will evaluate the benefit of induction chemotherapy followed by chemoradiotherapy, the role of surgery in locally advanced disease, and the identification of responders prior to treatment based on microarray analysis.
How I manage pulmonary Langerhans cell histiocytosis
Authors: Lorillon Gwenaël , Tazi Abdellatif 
Published: September 2017

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare sporadic cystic lung disease of unknown aetiology that is characterised by the infiltration and destruction of the wall of distal bronchioles by CD1a+Langerhans-like cells. In adults, PLCH is frequently isolated and affects young smokers of both sexes. Recent multicentre studies have led to the more standardised management of patients in clinical practice. Smoking cessation is essential and is occasionally the only suitable intervention. Serial lung function testing is important because a significant proportion of patients may experience an early decline in forced expiratory volume in 1 s and develop airflow obstruction. Cladribine was reported to dramatically improve progressive PLCH in some patients. Its efficacy and tolerance are currently being evaluated. Patients who complain of unexplained dyspnoea with decreased diffusing capacity of the lung for carbon monoxide should be screened for pulmonary hypertension by Doppler echocardiography, which must be confirmed by right heart catheterisation. Lung transplantation is a therapeutic option for patients with advanced PLCH.The identification of theBRAFV600Emutation in approximately half of Langerhans cell histiocytosis lesions, including PLCH, and other mutations of the mitogen-activated protein kinase (MAPK) pathway in a subset of lesions has led to targeted treatments (BRAF and MEK (MAPK kinase) inhibitors). These treatments need to be rigorously evaluated because of their potentially severe side-effects.
Postoperative Complications Affecting Survival After Cardiac Arrest in General Surgery Patients
Authors: Kim Minjae , Li Guohua 
Published: September 2017

BACKGROUND:
Postoperative cardiac arrest is uncommon but associated with a high mortality risk in general surgery patients and is often preceded by postoperative complications. The relationships between previous complications and mortality after cardiac arrest in general surgery patients have not been completely evaluated.

METHODS:
A retrospective, observational cohort of general surgery in patients with cardiac arrest occurring after postoperative day (POD) #0 (and up to POD #30) was obtained from the 2012–2013 American College of Surgeons National Surgical Quality Improvement Program. Previous complication was defined as at least one of the following occurring before the POD of cardiac arrest: (1) acute kidney injury; (2) acute respiratory failure; (3) deep vein thrombosis/pulmonary embolus; (4) myocardial infarction; (5) sepsis/septic shock; (6) stroke; and/or (7) transfusion. The associations between previous complications and mortality after cardiac arrest were assessed using Cox proportional hazards models that adjusted for preoperative risk factors.

RESULTS:
Of 1352 patients with postoperative cardiac arrest, 746 patients (55%) developed at least 1 complication before cardiac arrest. Overall 30-day mortality was 71% (958/1352) and was similar among patients with and without a previous complication (71% [533/746] vs 70% [425/606]; P = .60). Patients with previous complications did not have an increased risk of mortality, compared to patients without previous complications, in adjusted Cox models (hazard ratio, 1.03; 95% confidence interval, 0.90–1.18; P = .70). In addition, no previous complication was associated with increased mortality risk in individual analyses.

CONCLUSIONS:
Among general surgery patients with cardiac arrest after POD #0, complications occurring before cardiac arrest are common but are not associated with increased mortality risk.
Human pluripotent stem cell models of cardiac disease: from mechanisms to therapies
Authors: Brandão Karina O. , Tabel Viola A. , Atsma Douwe E. , Mummery Christine L. , Davis Richard P. 
Published: September 2017

ABSTRACT
It is now a decade since human induced pluripotent stem cells (hiPSCs) were first described. The reprogramming of adult somatic cells to a pluripotent state has become a robust technology that has revolutionised our ability to study human diseases. Crucially, these cells capture all the genetic aspects of the patient from which they were derived. Combined with advances in generating the different cell types present in the human heart, this has opened up new avenues to study cardiac disease in humans and investigate novel therapeutic approaches to treat these pathologies. Here, we provide an overview of the current state of the field regarding the generation of cardiomyocytes from human pluripotent stem cells and methods to assess them functionally, an essential requirement when investigating disease and therapeutic outcomes. We critically evaluate whether treatments suggested by these in vitro models could be translated to clinical practice. Finally, we consider current shortcomings of these models and propose methods by which they could be further improved.
Bioeffect of Negative Ionized Air Impact on the Course of Reparative Processes in the Organism after Gamma-irradiation
Authors: Татаркин С. , Tatarkin S. , Шафиркин А. , Shafirkin A. , Баранцева М. , Baranceva M. , Иванова С. , Ivanova S. , Ворожцова С. , Vorozhcova S. , Татаркина Л. , Tatarkina L. , Хуршут А. , Hurshut A. , Безгрешнов В. , Bezgreshnov V. 
Published: September 2017

Purpose: The integrated research of the reaction of the hematopoietic system, including hematopoietic, metabolic changes in the cells and modify their antioxidant capacity during the recovery period after radiation exposure at doses and concentrations that are typical for interplanetary flight: 1) in isolation, i.e. without any external influence; 2) under the influence of negatively ionized air.
Material and methods: The study was conducted on sexually mature mice of line F1(CBA×C57BL6) subject to the rules and regulations of biomedical ethics on the basis of SSC RF IBMP RAS. The pilot study included 2 stages: 1) fractionated γ-irradiation (350 cGy) with the duration of 63 days; 2) the recovery period, lasting 28 days, during which the animals were exposed to negatively ionized air (daily for 70 min). Studied cytological, morphological, biochemical parameters of hematopoiesis: the total number of nucleated cells (bone marrow); the amount of production of erythrocytes, reticulocytes, hemoglobin (in peripheral blood); the content of ATP, lactate, glutathione, activity of glucose-6-phosphate dehydrogenase (G6PD), lactate dehydrogenase (LDH) (in erythrocyte); the ratio and amount of lipid fractions (in the membrane of erythrocytes).
Results: The biological effect of the impact of negatively ionized air on the course of reparative processes in the body after gamma irradiation consists in the accelerated recovery of the number of peripheral blood cells and in a more pronounced degree of myeloid growth, due to:
•	increase in the rate of recovery of energy production processes (increase in LDH activity, improvement of lactate and ATP, and more pronounced normalization of oxidation-reduction processes), which facilitates recapitalization of cells with lipid membrane saturation with membrane cholesterol.
•	membrane-protective effect of negatively ionized air, based on the restoration of the membrane potential of cells expressing negative effects of blood cells;
•	increased life span of cells in peripheral blood and smaller values of the half-life of granulocytes from the bloodstream in the tissue.
The prevalence and incidence of diabetic foot ulcers among five countries in the Arab world: a systematic review
Authors: Mairghani M. , Elmusharaf K. , Patton D. , Burns J. , Eltahir O. , Jassim G. , Moore Z. 
Published: September 2017

Objective: There is a rising incidence of diabetes worldwide; however there seems to be a higher incidence and prevalence rates in the Arab world when compared with the global average. 1 Out of the top 10 countries with the highest prevalence rates, six are Arab countries and almost 20.5 million people in that part of the world live with diabetes. Despite this, published scientific research from the 22 Arab countries is limited and seems to be of lower quality when compared with the rest of the developed world. 2 Therefore, our aim was to explore the contribution of the different Arab countries in the world literature, to identify the diabetic foot ulcer (DFU) prevalence and incidence rates and to quality appraise these studies. Method: A systematic review, following PRISMA guidelines, was undertaken to identify the incidence and prevalence of DFUs in the Arab world. The following databases were searched: PubMed, Embase CINAHL, Web of Science (Scopus), Global Health and EBSCO Results: A total of nine papers were identified. The mean prevalence of DFU in Saudi Arabia was 11.85% (4.7–19%), in Egypt was 4.2% (1–7.4%), in Jordan was 4.65% (4–5.3%), in Bahrain was 5.9% and in Iraq was 2.7%. A single study identified DFU incidence in Saudi Arabia as 1.8% between 2009–2010. Conclusion: The mean prevalence rates of DFU were highest in Saudi Arabia and Bahrain and lowest in Iraq. Saudi Arabia had the only reported incidence study, thus findings could not be compared to other countries of the Arab world. There were no studies identified during our search reporting prevalence rates of DFU in 17 of the 22 Arab countries. It is clear that further research is required to determine the incidence and prevalance of DFUs in the Arab world and that progress is needed in order to improve the quality of research conducted in those countries.
Evaluation of osteopontin expression in chronic wounds: a potential prognostic and therapeutic biomarker
Authors: Chimento S. , Billero V. , Cavallin L. , Romanelli M. , Nadji M. , Romanelli P. 
Published: September 2017

Objective: Osteopontin (OPN) is abundantly expressed during tissue repair, acting as a powerful chemokine that recruits inflammatory cells such as neutrophils, macrophages, and Langerhans cells. The role of OPN in chronic wounds has not been explored. In this study, we assess the expression levels of OPN in chronic wounds to assess its potential contribution to the exacerbated inflammation seen in chronic ulcers, which is thought to contribute to poor healing. Methods: This retrospective study included archived biopsies of chronic wounds from several aetiologies. Immunohistochemical staining and blind analysis of OPN expression were carried out. Results: We assessed biopsies from venous leg ulcers (n=5), diabetic foot ulcers (n=5), pyoderma gangrenosum (n=5), squamous cell carcinoma ulcers (n=4), and calciphylaxis ulcers (n=3). The data revealed that all these sets of chronic ulcers expressed high levels of OPN. Conclusion: This study provides strong histopathologic evidence that OPN expression is significantly increased in chronic wounds, suggesting that its upregulation could contribute to the exacerbated inflammation. Furthermore, further characterisation of the role of OPN in wound healing could aid the development of specific and efficient anti-OPN therapies for the treatment of chronic wounds.
Very Deep Convolutional Neural Networks for Morphologic Classification of Erythrocytes
Authors: Durant Thomas J S , Olson Eben M , Schulz Wade L , Torres Richard 
Published: September 2017

Abstract

BACKGROUND
Morphologic profiling of the erythrocyte population is a widely used and clinically valuable diagnostic modality, but one that relies on a slow manual process associated with significant labor cost and limited reproducibility. Automated profiling of erythrocytes from digital images by capable machine learning approaches would augment the throughput and value of morphologic analysis. To this end, we sought to evaluate the performance of leading implementation strategies for convolutional neural networks (CNNs) when applied to classification of erythrocytes based on morphology.

METHODS
Erythrocytes were manually classified into 1 of 10 classes using a custom-developed Web application. Using recent literature to guide architectural considerations for neural network design, we implemented a “very deep” CNN, consisting of &gt;150 layers, with dense shortcut connections.

RESULTS
The final database comprised 3737 labeled cells. Ensemble model predictions on unseen data demonstrated a harmonic mean of recall and precision metrics of 92.70% and 89.39%, respectively. Of the 748 cells in the test set, 23 misclassification errors were made, with a correct classification frequency of 90.60%, represented as a harmonic mean across the 10 morphologic classes.

CONCLUSIONS
These findings indicate that erythrocyte morphology profiles could be measured with a high degree of accuracy with “very deep” CNNs. Further, these data support future efforts to expand classes and optimize practical performance in a clinical environment as a prelude to full implementation as a clinical tool.
Consensus of Heterogeneous Multi-Agent Systems with Intermittent Communication
Authors: Xu Lü , Meng Shuanghe , Chen Liang 
Published: September 2017

AbstractThis paper studies consensus of a class of heterogeneous multi-agent systems composed of first-order and second-order agents with intermittent communication. For leaderless multi-agent systems, we propose a distributed consensus algorithm based on the intermittent information of neighboring agents. Some sufficient conditions are obtained to guarantee the consensus of heterogeneous multi-agent systems in terms of bilinear matrix inequalities (BMIs). Meanwhile, the relationship between communication duration and each control period is sought out. Moreover, the designed algorithm is extended to leader-following multi-agent systems without velocity measurements. Finally, the effectiveness of the main results is illustrated by numerical simulations.
Inorganic Fertilization Effects on the Structure of a Calcareous Silt Loam Soil
Authors: Zhou Hu , Fang Huan , Hu Chunsheng , Mooney Sacha Jon , Dong Wenxu , Peng Xinhua 
Published: September 2017

Core Ideas
Long‐term inorganic fertilization decreased aggregate stability.
Long‐term inorganic fertilization decreased soil macroporosity.
Long‐term inorganic fertilization did not change soil organic C content.
Soil water‐holding capacity was not affected by inorganic fertilization.
Swine manure combined with inorganic fertilizers improved soil structure.
Inorganic fertilizers have been intensely used in the North China Plain (NCP) to maintain or increase crop yields, but their effects on soil physical properties, especially soil structure, are unclear. The objective of this study was to evaluate the effects of 12 yr of successive application of inorganic fertilization on soil aggregate stability, pore structure, and hydraulic properties of a calcareous silt loam soil. A long‐term field experiment (2001–2013) was established at Luancheng Ecosystem Station, NCP. The experiment included three fertilization treatments: (i) inorganic fertilizer, NPK; (ii) inorganic fertilizer and organic manure, NPKOM; and (iii) a control treatment with no fertilizer, CK. Results showed plots receiving long‐term NPK and NPKOM had significantly greater wheat (Triticum aestivum L.) (275 and 307%, respectively) and maize (Zea mays L.) yields (59 and 107%, respectively) than the control. However, the application of inorganic fertilizer significantly decreased aggregate stability and macroporosity, by 55.3 and 36.1%, respectively, relative to the control. No differences in soil organic carbon (SOC), bulk density (BD), saturated conductivity (Ks), and water‐holding capacity were found between the NPK and the CK treatments. On the other hand, the addition of organic manure with inorganic fertilizers increased SOC, total porosity, and saturated conductivity by 38.5, 5.2, and 75%, respectively, compared with the CK treatment. This study indicated inorganic fertilization alone could not improve soil structure of the calcareous silt loam, although it maintained high yields. Use of organic amendments along with inorganic fertilizers can improve soil structure and crop yields.