bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impacts of temperature anomalies on mortality of benthic organisms in the Adriatic Sea
Authors: Kružić Petar , Rodić Petra , Popijač Aleksandar , Sertić Maya 
Published: December 2016

AbstractRecurrent climate‐induced mass mortality episodes have been recorded in the Mediterranean Sea over the past 15 years, affecting rocky benthic communities. In this study, we provide for the first time a report on the annual mortality events of benthic sessile invertebrates occurring in the eastern part of the Adriatic Sea. Over the course of 14 consecutive years, we studied the sea temperature gradient to a depth of 40 m and found an abnormal summer warming trend and an increased frequency of above‐average temperatures. Mortality events were recorded in the summers of 10 observed years, in particular in 2009, when the highest mortality rates were recorded. Late in summer 2009, extensive mass mortality of sessile invertebrates was observed in the entire Eastern Adriatic Sea. We performed an analysis of selected target benthic species associated with mass mortality events with inter‐regional differences in hydrological and temperature conditions. We were able to characterize the mortality event by studying five areas covering the northern, central and southern regions of the Eastern Adriatic Sea. The degree of impact on each study area was quantified at 28 sites by estimating the proportion of affected target species. According to the obtained data, the northern sites (Cres area) were the least affected, whereas sites in the Central and Southern Adriatic [Telašćica and Lastovo Nature Parks, Mljet National Park (NP)] displayed the highest impact. In summer 2009, sea surface temperatures reached values of 28 °C in the Cres area and 30 °C in Mljet NP. These thermal conditions were concomitant with moderate to severe mass mortalities of benthic populations. Mass mortality events reached depths of 45 m in most parts of the affected areas. Amongst studied species, the scleractinian coral and gorgonian populations suffered the most extensive damage during the mass mortality events.
A systematic review of serious games in asthma education
Authors: Drummond David , Monnier Delphine , Tesnière Antoine , Hadchouel Alice 
Published: December 2016

AbstractBackgroundSerious games may be useful tools for asthma education. The objectives of this systematic review were to identify the available articles on serious games designed to educate patients and the general public about asthma and to assess their impact on patient's knowledge, behavior, and clinical outcomes related to asthma.MethodsPubMed, EMBASE, Cochrane Library, PsychInfo, and Web of Science were systematically searched from January 1980 to December 2015 for studies investigating serious games in asthma education. Two investigators independently assessed studies against inclusion criteria and rated those included on indicators of quality. Investigators extracted data on serious games’ content and learning objectives, and on outcomes following Kirkpatrick classification.ResultsA total of 12 articles were found to be relevant, describing a total of 10 serious games. All serious games were directed toward children, with eight games for children with asthma and two for school‐based intervention. The average Medical Education Research Study Quality Instrument score was 13.9 of 18, which is high. Most of the serious games were associated with high rates of satisfaction and improvement in children's knowledge. Seven studies evaluated the impact of serious games on clinical outcomes and found no significant difference relative to control groups.ConclusionsAlthough serious games designed for asthma education have evolved with advances in technology, results of their evaluation remained similar across studies, with clear improvements in knowledge but little or no change in behaviors and clinical outcomes.
Quantification of surgical margin length changes after excision of feline injection site sarcomas—A pilot study
Authors: Terry Jesse L. , Milovancev Milan , Nemanic Sarah , Löhr Christiane V. 
Published: December 2016

AbstractObjectiveTo evaluate degree length change of lateral surgical margins at various stages of processing for histological examination and quantify the length change between grossly normal surgical margins (GNSM) and pathologist‐reported histologic tumor‐free margin (HTFM) in widely resected feline injection site sarcoma (FISS) specimens.Study DesignProspective clinical study.AnimalsFive client‐owned cats with injection site sarcomas.MethodsAll cats underwent wide surgical excision (35‐55 mm gross lateral margins, 2 fascial planes deep). Gross normal lateral margin measurements from tumor edge were recorded in 4 directions (cranial, caudal, dorsal, ventral) at 5 time points: intra‐op (in vivo GNSM); immediately following excision (ex vivo GNSM); following formalin fixation (post‐fixation GNSM); after trimming and mounting on glass slides (on‐slide GNSM); and HTFM at the narrowest point from the HTFM from the same slides used for on‐slide GNSM. Percent change in lateral margin length from in vivo measurements was quantified at each time point and compared using 1‐way repeated measures ANOVA.ResultsThe largest mean decrease in percent GNSM length occurred immediately after excision (in vivo to ex vivo GNSM = 29%;P = .016). Formalin fixation, trimming, and mounting on slides did not result in additional significant changes in length. Mean HTFM length was significantly decreased compared to both in vivo GNSM (33%;P = .014) and on‐slide GNSM (7%;P = .024).ConclusionSignificant decreases in surgical margin length in FISS specimens occur immediately following excision (prior to formalin fixation). Subgross evaluation of tumor‐free margins from on‐slide GNSM to HTFM overestimates the actual (histologic) tumor‐free margins.
DIALEKTIKA TOKOH-TOKOH FALSAFAH BARAT ZAMAN REVOLUSI SAINS MENGENAI SAINS DAN NILAI
Authors: Alias Mohd Syahmir 
Published: December 2016

AbstractScientific Revolution which happened in Europe beginning from 17th to 18th century show the philosophers of science such as Francis Bacon and Immanuel Kant appeared with their ideas to strengthen the scientific methodology. Among the issues being debated is relevance of values towards science. However, different perspectives from these philosophers lead to the dialectic between science and values. This raises a question mark about their arguments and conclusions regarding the issue between science and values. Therefore, this paper aims to identify the outstanding philosophers of science whose involved in such debate from 17th to 18th century AD with their arguments. Next, the paper aims to analyze the relationship among these philosophers and their conception of science and values. Based on the content analysis method used, there are three important findings. First, Francis Bacon, the founder of Western scientific methods reject the practice of confounding superstitions and human biasness in scientific research. Second, there is a clear continuity between the thought of René Descartes, David Hume and Immanuel Kant’s dualism of science, but with different perspectives, i.e. mind-body dualism, fact-value dualism, phenomena-noumena dualism respectively. Third, the arguments of these philosophers of science, especially Kant implied in the concept of value-free scientific research for the following centuries. AbstrakRevolusi Sains yang berlaku di Eropah pada abad ke-17 hingga abad ke-18 Masihi menyaksikan tokoh-tokoh falsafah sains seperti Francis Bacon dan Immanuel Kant tampil bersama idea-idea mereka untuk memantapkan metodologi saintifik. Antara perkara yang dibahaskan ialah perkaitan sains dengan nilai. Walau bagaimanapun, perbezaan pandangan tokoh-tokoh ini membawa kepada dialektika tentang sains dan nilai. Hal ini menimbulkan tanda tanya mengenai hujah-hujah mereka dan kesimpulan yang dibuat berkenaan sains dengan nilai. Justeru, makalah ini ditulis dengan dua tujuan utama. Pertama, mengenal pasti konteks perbahasan sains dan nilai oleh tokoh-tokoh falsafah sains abad ke-17 hingga abad ke-18 yang terlibat. Kedua, menganalisis perkaitan antara pemikiran tokoh-tokoh tersebut berkenaan konsepsi mereka tentang hubungan sains dan nilai. Berdasarkan kaedah analisis kandungan yang digunakan, makalah ini mendapati tiga dapatan penting. Pertama, Francis Bacon selaku pengasas kaedah saintifik Barat menolak amalan campur aduk perkara khurafat dan berat sebelah dalam penyelidikan sains. Kedua, terdapat kesinambungan yang jelas di antara pemikiran René Descartes, David Hume dan Immanuel Kant mengenai dualisme ilmu, namun dari perspektif yang berbeza. Ketiga, hujah-hujah kesemua tokoh falsafah sains tersebut, khususnya Kant memberi implikasi kepada konsep bebas nilai dalam penyelidikan saintifik bagi abad-abad berikutnya.
Prospective evaluation of Quasistatic Ultrasound Elastography (USE) compared with Baseline US for parotid gland lesions: preliminary results of elasticity contrast index (ECI) evaluation
Authors: Cantisani Vito , David Emanuele , De Virgilio Armando , Sidhu Paul S. , Grazhdani Hektor , Greco Antonio , De Vincentiis Marco , Corsi Alessandro , De Cristofaro Flaminia , Brunese Luca , Calliada Fabrizio , Blandino Alfredo , Tombolini Mario , Ascenti Giorgio , Stramare Roberto , Caratozzolo Marcello , D’Ambrosio Ferdinando 
Published: December 2016

Aims: To assess the diagnostic value of elasticity contrast index (ECI) elastography, in comparison with conventional ultrasound for the differentiation of benign and malignant parotid lesions. Material and methods: Sixty-three consecutive patients with parotid gland tumors, treated surgically at a single tertiary center were enrolled. Ultrasound evaluation consisted of B-mode, color-Doppler and quasistatic ultrasound elastography (USE), conducted with the ECI technique. For each lesion the echogenicity, margins, vascularization, and capsulation were considered to determine benign or malignant lesions. Histology was considered the gold standard. Results: Using conventional parameters, the observer suggested malignant lesions in 20 cases and benign lesions in 43 cases (accuracy: 61.8%). ECI>3.5 alone was the most accurate parameter (accuracy: 90.5%), with sensitivity of 93.7% and specificity of 89.4%. However, when combined with the other US criteria, no statistically significant diagnostic accuracy improvement was achieved. Conclusions: Our results show that USE with ECI index measurement can help to discriminate preoperatively benign from malignant lesions, with the exception of pleomorphic adenoma which is stiff. We suggest that USE can be used as an additional tool to conventional US evaluation of salivary gland lesions.
A Community-Based Exergaming Physical Activity Program Improves Readiness-to-Change and Self-Efficacy Among Rural-Residing Older Adults
Authors: Sowle Ashleigh J. , Francis Sarah L. , Margrett Jennifer A. , Shelley Mack C. , Franke Warren D. 
Published: December 2016

Rural-residing older adults (OA) are not meeting physical activity (PA) recommendations, such that identifying methods of increasing PA among OA remains an ongoing challenge. This study evaluated the effect of a community-based exergaming program on PA readiness-to-change and self-efficacy among rural-residing OA (n = 265). There was a significant (p = .008) increase in readiness-to-change classification from PRE to POST. Significant increases in self-efficacy, or confidence in their ability to be physically active for a prescribed period of time, were detected for 35 (p = .011) and 40 min (p = .035) of continuous PA. PA self-efficacy change for 35 min of continuous PA (F [3,137] = 3.973, p = .010) and 40 min of continuous PA (F [3,137) = 2.893, p = .038) were influenced by the interaction between PRE self-reported health and PRE PA readiness-to-change levels. Results suggest that an exergaming-themed PA intervention is effective at increasing PA participation and self-efficacy for PA among rural-residing OA.
Toe-in Landing Increases the Ankle Inversion Angle and Moment During Single-Leg Landing: Implications in the Prevention of Lateral Ankle Sprains
Authors: Koshino Yuta , Ishida Tomoya , Yamanaka Masanori , Samukawa Mina , Kobayashi Takumi , Tohyama Harukazu 
Published: December 2016

Context:Identifying the foot positions that are vulnerable to lateral ankle sprains is important for injury prevention. The effects of foot position in the transverse plane on ankle biomechanics during landing are unknown.Objective:To examine the effects of toe-in or toe-out positioning on ankle inversion motion and moment during single-leg landing.Design:Repeated measures.Setting:Motion analysis laboratory.Participants:18 healthy participants (9 men and 9 women).Interventions:Participants performed single-leg landing trials from a 30-cm high box under 3 conditions: natural landing, foot internally rotated (toe-in), and foot externally rotated (toe-out).Main Outcome Measures:4 toe-in or toe-out angles were calculated against 4 reference coordinates (laboratory, pelvis, thigh, and shank) in the transverse plane. Ankle inversion angle, angular velocity, and external moment in the 200 ms after initial foot-to-ground contact were compared between the 3 landing conditions.Results:All toe-in or toe-out angles other than those calculated against the shank were significantly different between each of the 3 landing conditions (P < .001). Ankle inversion angle, angular velocity, and moment were highest during toe-in landings (P < .01), while eversion angle and moment were highest during toe-out landings (P < .001). The effect sizes of these differences were large. Vertical ground reaction forces were not different between the 3 landing conditions (P = .290).Conclusions:Toe-in or toe-out positioning during single-leg landings impacts on ankle inversion and eversion motion and moment. Athletes could train not to land with the toe-in positioning to prevent lateral ankle sprains.
Effects of a Novel Neurodynamic Tension Technique on Muscle Extensibility and Stretch Tolerance: A Counterbalanced Crossover Study
Authors: Pietrzak Max , Vollaard Niels B.J. 
Published: December 2016

Context: Neurodynamic tension affects hamstring extensibility and stretch tolerance and is considered important in hamstring injury management. Neurodynamic tension was postulated to affect segmental muscle extensibility and stretch tolerance and potentially also to demonstrate extrasegmental and contralateral effects. Objectives: To assess the effects of a novel sciatic-tibial neurodynamic tension technique, the modified long sit slump (MLSS), on segmental, extrasegmental, and contralateral muscle extensibility and stretch tolerance. Study Design: Counterbalanced crossover study. Setting: University research laboratory. Participants: 13 healthy and active subjects (mean ± SD age 24 ± 8 y; BMI, 23.1 ± 2.8 kg/m2). Intervention: MLSS application (5 s, 5 repetitions, 3 sets) on 2 occasions with a 3-wk washout period, and either stance- or skill-leg treated in a counterbalanced manner. Main Outcome Measures: Segmental and extrasegmental muscle extensibility was measured using passive straight-leg raise (PSLR) and prone knee bend (PKB) at pre-, immediately post-, and 1 h postintervention. Stretch-intensity ratings were measured using a simple numerical rating scale (SNRS). Results: MLSS significantly increased PSLR and PKB bilaterally (P < .001). The effect for PSLR was greater in the ipsilateral leg compared to the contralateral leg (baseline to 1 h post: +9° ± 6° and +5° ± 5°, respectively, P < .001) but not for PKB (baseline to 1 h post: ipsilateral leg +5° ± 5°, contralateral leg +5° ±  4°). For both PSLR and PKB the effect of the first session was retained at the start of the second session 3 wk later. SNRS data were consistent with increased stretch tolerance. Conclusions: Application of a novel sciatic-tibial neurodynamic tension technique, the MLSS, increases muscle extensibility and stretch tolerance segmentally, extrasegmentally and contralaterally. Level of Evidence: 2C outcomes research.
Mesozoic phytoclast records in the Sriperumbudur (Palar Basin), Kota (Chintalapudi Sub-Basin) and Dubrajpur (Rajmahal Basin) formations, India
Authors: Duarte Sarah Gonçalves , Jha Neerja , Joshi Harinam , Tavares Eliana Schwartz , Arai Mitsuru , Wanderley Maria Dolores 
Published: December 2016

The studies of fossil plant cuticles in palynological samples recovered from three cored boreholes located in the Indian states of Andhra Pradesh (Kota/Gangapur Formation, Chintalapudi Sub-basin, Godavari Graben, Jurassic–Cretaceous), Tamil Nadu (Sriperumbudur Formation, Palar Basin, Upper Jurassic–lowermost Cretaceous), and Jharkhand (Dubrajpur Formation, Rajmahal Basin, Upper Jurassic–Lower Cretaceous) are presented herein. Cuticles and palynomorphs were recovered by standard palynological practices in the Gondwana Palynological Laboratory of the Birbal Sahni Institute of Palaeosciences, Lucknow, India. Fossil specimens were examined under a binocular microscope and photomicrographs were taken with a digital camera. Twenty seven morphotypes of fossil cuticles (occasionally representing stomata, trichomes and secretory structures) and other tissues (e.g., a plicate parenchyma) were recovered. The morphological analysis of cuticles and associated palynomorphs reflect the presence of different groups of plants (Bennettitales, Coniferales, Ginkgoales, Polypodiales, and Pteridospermales). In some occasions, cuticles display distinct structures (e.g., monocyclic stomata, secretory structures) that allow comparisons with some extant and fossil genera. We conclude that the study of well-preserved fossil cuticles and associated palynomorphs allow taxonomic inferences on the composition of the parent floras.
A palynostratigraphic study of the Umrer Coalfield of Wardha Basin, Maharashtra State, Central India and its putative correlation with Indian and other Gondwanan areas
Authors: Kavali Pauline Sabina , Shivanna Mahesh , Lingappa Mahesh Bilwa , Bernardes-de-Oliveira Mary Elizabeth Cerruti 
Published: December 2016

The present work details the results of the palynological studies carried out in the Umrer Coalfield of Wardha Basin of Maharashtra State, Central India. The coalfield covers an area of 4 sq. km and is characterized by three coal seams designated as bottom, middle and top seams with partings. Statistical analysis of the palynomorphs from these sediments have revealed the dominance of radial monosaccate pollen grains of the genus Parasaccites and subdominance of non-striate bisaccate genus Scheuringipollenites in association with other typical early Permian taxa viz. Crucisaccites, Callumispora, Caheniasaccites, Brevitriletes, Tiwariasporis and Primuspollenites. This association characterizes the palynoflora of the upper Karharbari Formation of India on the basis of which the Umrer Coalfield has been assigned an early Permian late Sakmarian to early Artinskian age. It is further authenticated by the presence of the species Crucisaccites monoletus significant of the Karharbari Formation. Age deductions have also been made by correlations with similar assemblages from different basins in India and early Permian palynoflora from other Gondwanan continents some of which have been associated with radiometrically dated sediments.
The Pivotal Role of the Right Parietal Lobe in Temporal Attention
Authors: Agosta Sara , Magnago Denise , Tyler Sarah , Grossman Emily , Galante Emanuela , Ferraro Francesco , Mazzini Nunzia , Miceli Gabriele , Battelli Lorella 
Published: December 2016

Abstract
The visual system is extremely efficient at detecting events across time even at very fast presentation rates; however, discriminating the identity of those events is much slower and requires attention over time, a mechanism with a much coarser resolution [Cavanagh, P., Battelli, L., & Holcombe, A. O. Dynamic attention. In A. C. Nobre & S. Kastner (Eds.), The Oxford handbook of attention (pp. 652–675). Oxford: Oxford University Press, 2013]. Patients affected by right parietal lesion, including the TPJ, are severely impaired in discriminating events across time in both visual fields [Battelli, L., Cavanagh, P., & Thornton, I. M. Perception of biological motion in parietal patients. Neuropsychologia, 41, 1808–1816, 2003]. One way to test this ability is to use a simultaneity judgment task, whereby participants are asked to indicate whether two events occurred simultaneously or not. We psychophysically varied the frequency rate of four flickering disks, and on most of the trials, one disk (either in the left or right visual field) was flickering out-of-phase relative to the others. We asked participants to report whether two left-or-right-presented disks were simultaneous or not. We tested a total of 23 right and left parietal lesion patients in Experiment 1, and only right parietal patients showed impairment in both visual fields while their low-level visual functions were normal. Importantly, to causally link the right TPJ to the relative timing processing, we ran a TMS experiment on healthy participants. Participants underwent three stimulation sessions and performed the same simultaneity judgment task before and after 20 min of low-frequency inhibitory TMS over right TPJ, left TPJ, or early visual area as a control. rTMS over the right TPJ caused a bilateral impairment in the simultaneity judgment task, whereas rTMS over left TPJ or over early visual area did not affect performance. Altogether, our results directly link the right TPJ to the processing of relative time.
Salience Network Connectivity Modulates Skin Conductance Responses in Predicting Arousal Experience
Authors: Xia Chenjie , Touroutoglou Alexandra , Quigley Karen S. , Feldman Barrett Lisa , Dickerson Bradford C. 
Published: December 2016

AbstractIndividual differences in arousal experience have been linked to differences in resting-state salience network connectivity strength. In this study, we investigated how adding task-related skin conductance responses (SCR), a measure of sympathetic autonomic nervous system activity, can predict additional variance in arousal experience. Thirty-nine young adults rated their subjective experience of arousal to emotionally evocative images while SCRs were measured. They also underwent a separate resting-state fMRI scan. Greater SCR reactivity (an increased number of task-related SCRs) to emotional images and stronger intrinsic salience network connectivity independently predicted more intense experiences of arousal. Salience network connectivity further moderated the effect of SCR reactivity: In individuals with weak salience network connectivity, SCR reactivity more significantly predicted arousal experience, whereas in those with strong salience network connectivity, SCR reactivity played little role in predicting arousal experience. This interaction illustrates the degeneracy in neural mechanisms driving individual differences in arousal experience and highlights the intricate interplay between connectivity in central visceromotor neural circuitry and peripherally expressed autonomic responses in shaping arousal experience.
US intergroup study of chemotherapy plus dasatinib and allogeneic stem cell transplant in Philadelphia chromosome positive ALL
Authors: Ravandi Farhad , Othus Megan , O'Brien Susan M. , Forman Stephen J. , Ha Chul S. , Wong Jeffrey Y. C. , Tallman Martin S. , Paietta Elisabeth , Racevskis Janis , Uy Geoffrey L. , Horowitz Mary , Takebe Naoko , Little Richard , Borate Uma , Kebriaei Partow , Kingsbury Laura , Kantarjian Hagop M. , Radich Jerald P. , Erba Harry P. , Appelbaum Frederick R. 
Published: December 2016

Key Points
Addition of dasatinib to chemotherapy followed by allogeneic stem cell transplant is well tolerated in younger patients with Ph+ ALL. Landmark analysis showed statistically superior advantages for relapse-free and overall survival for the transplanted patients.