bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: SYNTHESIS OF SINGLE ISOMERS (E OR Z) OF UNSATURATED ALCOHOLS BY THE HORNER‐WITTIG REACTION
Authors: BUSS A. D. , GREEVES N. , LEVIN D. , WALLACE P. , WARREN S. 
Published: May 2016

AbstractAus den Phosphinoxiden (I) entstehen nach Metallierung mit Lactonen (II) die Hydroxyalkylketone (III), die mit Boranat zu (IV) reduziert werden und mit NaH zu Olefinen (V) eliminiert werden.
ChemInform Abstract: A NOVEL APPROACH TO AMINOCYCLITOL ANALOGS FROM AZIDOTRIDEOXYHEX‐5‐ENOPYRANOSIDES
Authors: PELYVAS I. , SZTARICSKAI F. , BOGNAR R. 
Published: May 2016

AbstractBei Behandlung des Tridesoxyhexenopyranosids (I) mit Quecksilber(II)‐ chlorid entsteht anstelle des erwarteten Ketons (III) das Cyclohexenon (II).
ChemInform Abstract: REACTIONS OF ORGANIC ANIONS. 111. SOME CARBANIONIC REACTIONS OF α‐CHLOROALLYL SULFONES
Authors: JONCZYK A. , RADWAN‐PYTLEWSKI T. 
Published: May 2016

AbstractDurch. Umsetzung des Sulfons (I) mit Hexachlorethan (II) oder mit dem Dichlorbutenylsulfon (IV) entsteht ein α‐Chlorallylsulfon (III), das sich in situ mit Alkylhalogeniden, aktivierten Olefinen und aromatischen Aldehyden zu verschiedenen Derivaten umsetzen läßt, wie im Formelschema skizziert.
ChemInform Abstract: EFFICIENT SYNTHESIS OF BICYCLO(5.3.0)DECATRIENONES AND OF 2‐TETRALONES VIA RHODIUM(II) ACETATE‐CATALYZED CYCLIZATION OF α‐DIAZOKETONES DERIVED FROM 3‐ARYLPROPIONIC ACIDS
Authors: MCKERVEY M. A. , TULADHAR S. M. , TWOHIG M. F. 
Published: May 2016

AbstractIn Gegenwart eines Rhodiumkatalysators cyclisieren die Diazoketone (Ia) und (Ib)‐(Id) zu den bicyclischen Ketonen (II) bzw. (V), die sich in die 2‐TetraIone (IV) umlagem.
ChemInform Abstract: Tricyclic [10]Annulenes. Part 3. Reactions of 7b‐Methyl‐7bH‐cyclopent[cd]indene.
Authors: MCCAGUE R. , MOODY C. J. , REES C. W. 
Published: May 2016

AbstractEs werden die chemischen Eigenschaften der Titelverbindung (II) untersucht.
ChemInform Abstract: ACETALATION STUDIES, PART V. SOME ASPECTS OF THE REACTION OF GLYCEROL WITH 2,2‐DIMETHOXYPROPANE
Authors: CHITTENDEN G. J. F. 
Published: May 2016

AbstractGlycerin (I) reagiert mit Dimethoxypropan (II) zum racemischen Dioxolan (III), zum Dioxan (IV), zum racemischen Dioxolan (V) und zum Racemat der Diastereomeren (VI).
ChemInform Abstract: A NEW METHOD FOR THE PREPARATION OF 2‐ALKOXYBENZOXAZOLES
Authors: YAMATO M. , TAKEUCHI Y. , HATTORI K. , HASHIGAKI K. 
Published: May 2016

AbstractBenzoxazolthion (I) wird mit Methyliodid (II) alkyliert und mit Alkoholen (III) in die Alkoxy‐benzoxazole (IV) übergefülhrt.
ChemInform Abstract: X:YZH SYSTEMS AS POTENTIAL 1,3‐DIPOLES. PART 2. OXIME CYCLOADDITIONS: FORMATION OF 2:1 ADDUCTS
Authors: GRIGG R. , JORDAN M. , TANGTHONGKUM A. , EINSTEIN F. W. B. , JONES T. 
Published: May 2016

AbstractBei der Cycloaddition der Olefine (II) and die Oxime (I) entstehen die 2:1‐Addukte (III) und (IV).
ChemInform Abstract: ISOXAZOLIDINES BY CYCLOADDITIONS OF N,α‐DIPHENYL NITRONE IN THE BENZO(B)THIOPHENE S‐OXIDE AND S,S‐DIOXIDE SERIES
Authors: BENED A. , DURAND R. , PIOCH D. , GENESTE P. , GUIMON C. , PFISTER GUILLOUZO G. , DECLERCQ J. P. , GERMAIN G. , BRIARD P. , RAMBAUD J. , ROQUES R. 
Published: May 2016

AbstractDie 1,3‐dipolare Cycloaddition des Nitrons (II) an die Sulfone (I) und die Sulfoxide (V) verläuft in fast allen Fällen stereoselektiv unter ausschließlicher Bildung der Dihydrobenzothienoisoxazolidine (III) bzw. (VI), wobei eine lEpimerisierung in "syn" (S‐O‐Bindung und R′ liegen auf entgegengesetzen Seiten der Benzothiophenring‐Ebene) und "anti" nur im Falle (IIIe) beobachtet wurde.
ChemInform Abstract: 2‐(N,N‐Disubstituted Amino)thiazoles with Electron‐withdrawing Groups at Position 5: Preparation and Investigation of Structural Features.
Authors: BIRKINSHAW T. N. , GILLON D. W. , HARKIN S. A. , MEAKINS G. D. , TIREL M. D. 
Published: May 2016

AbstractKondensation von Thio‐harnstoffen (I) mit Ketonen (II), (IV), (VI) liefert die Thiazole (III), (Va) [nachfolgende Verseifung/Decarboxylierung→(Vb)] bzw. (VII).
ChemInform Abstract: THE SYNTHETIC REACTIONS OF ALIPHATIC NITRO COMPOUNDS. XXIV. FORMATION OF N,1‐BIS(3‐PHENYL‐1,2,4‐OXADIAZOL‐5‐YL)DIMETHYLAMINES
Authors: ZEN S. , NISHINO T. , HARADA K. , NAKAMURA H. , IITAKA Y. 
Published: May 2016

AbstractDie primären Nitroalkane (I) reagieren mit Kreatinin (II) zu den Oxadiazol‐Derivaten (III).
ChemInform Abstract: 2‐(PHENYLTHIO)‐2‐PENTEN‐5‐OLIDE, A NEW BUILDING BLOCK FOR THE SYNTHESIS OF 3‐SUBSTITUTED Δ‐LACTONES
Authors: KATO M. , OUCHI A. , YOSHIKOSHI A. 
Published: May 2016

AbstractAus ö‐Valerolacton (I) wird durch Lithierung mit LDA, nachfolgende Umsetzung mit Diphenyldisulfid und anschließende Oxidation das Phenylthio‐pentenolid (III) hergestellt.
ChemInform Abstract: NITRO DERIVATIVES OF 2‐(DIALKYLAMINO)CHROMONES. I. SYNTHESIS OF 3‐NITRO AND 3‐AMINO‐2‐(DIALKYLAMINO)CHROMONES
Authors: BALBI A. , ROMA G. , MAZZEI M. , ERMILI A. 
Published: May 2016

AbstractBei der Nitrierung erhält man je nach Reaktionsbedingungen aus den Aminochromonen (I) bzw. (IV) die G‐Nitro‐ bzw. die 3,6‐Dinitroamino‐chromone (II) und (III) bzw. (V).
ChemInform Abstract: PYRIMIDINE DERIVATIVES AND RELATED COMPOUNDS. XLVI. THERMAL AND PHOTOCHEMICAL L TRANSFORMATION OF 5‐SUBSTITUTED 6‐AZIDO‐1,3‐DIMETHYLURACILS INTO FUSED PYRIMIDINES SUCH AS ISOXAZOLO(3,4‐D)PYRIMIDINES, PYRAZOLO(3,4‐D)PYRIMIDINES, AND PYRIMIDO(4,5‐D)(1,2,3)TRIAZINE
Authors: HIROTA K. , MARUHASHI K. , ASAO T. , KITAMURA N. , MAKI Y. , SENDA S. 
Published: May 2016

AbstractDas aus dem Azidouracil (I) oder dem Chlor‐formyluracil (III) zugängliche Azido‐formyluracil (II) wird zahlreichen Umsetzungen unterworfen.
ChemInform Abstract: CARDIOVASCULAR EFFECTS OF 1,2,4‐BENZOTHIADIAZINE 1,1‐DIOXIDE DERIVATIVES. IX
Authors: PARENTI C. , DI BELLA M. , RAFFA L. , BAGGIO G. G. , GUARINI S. 
Published: May 2016

AbstractDurch Umsetzung mit Methyliodid erhält man aus den Aminoalkylamino‐benzothiadiazinen (I) die entsprechenden quartären Ammoniumsalze (II).
ChemInform Abstract: PREPARATION OF 11‐HYDROXYMETHYL‐2,3‐NAPHTHO‐18‐CROWN‐6 AND ITS CONVERSION INTO A HIGHLY LIPOPHILIC CROWN CARBOXYLIC ACID
Authors: CZECH B. , CZECH A. , BARTSCH R. A. 
Published: May 2016

AbstractNach den im Formelschema angegebenen Verfahren wird aus dem Dihydroxynaphthol (I) die Kronenether‐carbonsäure (Xb) hergestellt.
ChemInform Abstract: SYNTHESIS OF POTENTIAL DRUGS BASED ON HYDROPHOSPHORYLIC COMPOUNDS. PART IV. SYNTHESIS AND ANTIMYCOTIC ACTIVITY OF UNSATURATED ORGANOPHOSPHORUS COMPOUNDS
Authors: YUDELEVICH V. I. , BELAKHOV V. V. , BELYAEVA T.N. , SERGIENKO L.V. , KOMAROV E. V. , IONIN B. I. , MIKHAILOVA M. A. , ARAVIISKII R. A. 
Published: May 2016

AbstractDurch Kombination der bekannten Wirkungsprinzipien von phosphororganischen Fungiciden und Polyen‐Antibiotica mit hoher fungicider Wirkung sollen neue Wirkstoffe gefunden werden.
ChemInform Abstract: STRUCTURAL AND SPECTROSCOPIC CHARACTERIZATION OF COMPLEXES CONTAINING THE MONONUCLEAR TRIHALOMETALLATES TRIIODOCUPRATE(I), TRIBROMOCUPRATE(I), AND TRIODOARGENTATE(I). CRYSTAL STRUCTURE OF BIS(METHYLTRIPHENYLPHOSPHONIUM) TRIIODOCUPRATE(I)
Authors: BOWMAKER G. A. , CLARK G. R. , ROGERS D. A. , CAMUS A. , MARSICH N. 
Published: May 2016

AbstractDurch Auflösen von Metall(I)‐Halogeniden in einer Lösung von [PMePh3]l wurden die neuen Verbindungen (I) dargestellt.
ChemInform Abstract: DIMERIC NAPHTHOQUINONES. IX. ISODIOSPYRIN AND ELLIPTINONE. SYNTHESIS OF 6,6′‐DIMERIC BIJUGLONES BY PHENOL OXIDATION
Authors: LAATSCH H. 
Published: May 2016

AbstractZur näheren Untersuchung von dimeren Naphthochinonen, die durch Oxidation von Inhaltsstoffen tropischer Hölzer entstehen, wird eine Synthese solcher Verbindungen durchgeführt.
ChemInform Abstract: METALLOPORPHYRINS IN COAL. 1. GALLIUM IN BITUMINOUS COALS
Authors: BONNETT R. , CZECHOWSKI F. 
Published: May 2016

AbstractIn den End‐Fraktionen des säulenchromatographisch an Silicagel aufgetrennten schwefelsauer‐methanolischen Extrakts von bituminöser Kohle wurde eine homologe Reihe von Galliumporphyrinen (C26‐C32; Maximum bei C30) gefunden (Gesamtkonzentration ca. 0.2 ug/ g Kohle; Elektronen‐, 1H‐NMR‐ und Massenspektren).
ChemInform Abstract: ASYMMETRIC TOTAL SYNTHESIS OF ANTILEUKEMIC SESQUITERPENE (+)‐IVALIN
Authors: TOMIOKA K. , MASUMI F. , YAMASHITA T. , KOGA K. 
Published: May 2016

AbstractDie Synthese von (+)‐Ivalin (VI), einem antileukämischen Sesquiterpen, wird, ausgehend von dem Cyclohexadien (I), in der angegebenen Weise beschrieben.
ChemInform Abstract: A SIMPLIFIED, ONE STEP SYNTHESIS OF CHOLEST‐5‐EN‐3‐ONE
Authors: PARISH E. J. , CHITROKORN S. 
Published: May 2016

AbstractDas 5‐Cholestenon (III) wird in einer Stufe aus Cholesterin (I) durch Oxidation mit Pyridiniumchlorochromat hergestellt.
ChemInform Abstract: CLAY‐SUPPORTED REAGENTS. 5. NITRATION OF ESTRONE INTO 2‐NITROESTRONE BY CLAY‐SUPPORTED FERRIC NITRATE
Authors: CORNELIS A. , LASZLO P. , PENNETREAU P. 
Published: May 2016

AbstractEstron (I) wird mit einem an Bentonit absorbierten Eisen?lp‐nitrat‐hydrat glatt in Z‐Stellung zu (III) nitriert.
ChemInform Abstract: THE SYNTHESIS OF HIGH PURITY Nα‐BENZYLOXYCARBONYL Nε‐TERT‐BUTYLOXYCARBONYL‐L‐LYSINE
Authors: CHEN S. T. , WANG K. T. 
Published: May 2016

AbstractEs wird ein Verfahren zur isomerenfreien Herstellung von α‐2‐e‐Boc‐Lysin (IV) beschrieben.
ChemInform Abstract: SUGAR 1,3,4‐OXADIAZOLES. VII. CYCLIZATION OF ACETATES OF SUGAR AROYLHYDRAZONES USING LEAD TETRAACETATE
Authors: NASSR M. A. M. 
Published: May 2016

AbstractDie Zucker‐benzoylhydrazone (I) werden durch Bleitetraacetat (II) zu den Oxadiazolen (III) oxidiert.
ChemInform Abstract: DIRECT CONDENSATION OF POLYHYDRIC PHENOLS WITH GLUCOSE
Authors: ONODERA J. , TAKANO M. , KISHI Y. , YOKOYAMA N. , ISHIDA R. 
Published: May 2016

AbstractGlucose (I) reagiert mit zwei‐ und dreiwertigen Phenolen (II) in Gegenwart von p‐Toluolsulfonsäure in Dimethylsulfoxid als Lösungsmittel zu Glucopyranosiden (III), wobei die Bildung der α‐Anomeren bevorzugt ist.
ChemInform Abstract: A NEW CLASS OF NITROSOUREAS. IX. SYNTHESIS AND ANTITUMOR ACTIVITY OF 3‐SUBSTITUTED 1‐(2‐CHLOROETHYL)‐3‐(METHYL α‐D‐GLUCOPYRANOSID‐6‐YL OR METHYL 2‐ACETAMIDO‐2‐DEOXY‐α‐D‐GLUCOPYRANOSID‐6‐YL)‐1‐NITROSOUREAS
Authors: MORIKAWA T. , TSUJIHARA K. , TAKEDA M. , ARAI Y. 
Published: May 2016

AbstractAus den Glucopyranose‐Derivaten (I) werden auf dem im Formelschema angegebenen Weg die Nitrosoharnstoffe (V), die Antitumorwirkung zeigen, hergestellt.
ChemInform Abstract: STEREOCHEMISTRY OF NUCLEOPHILIC ADDITION REACTIONS, PART XII. REACTIONS OF METHYL 4,6‐O‐BENZYLIDENE‐2,3‐DIDEOXY‐3‐NITRO‐α‐ AND ‐β‐D‐ERYTHRO‐HEX‐2‐ENOPYRANOSIDES WITH PHENYLACETONITRILE: PREPARATION AND STRUCTURAL DETERMINATION OF ADDUCTS AND AN ISOXAZOLE DERIVATIVE
Authors: SAKAKIBARA T. , SUDOH R. 
Published: May 2016

AbstractDie Reaktion des He xenopyranosids (Ia) mit Phenylacetonitril ergibt bevorzugt dievdiastereomeren Glycoside (II) mit manno‐Konfiguration neben dem Glucosid (III), dem Isoxazol (IV), dem Cyanalken (V) und den Nitroalkoholen (VI) und (VII).
ChemInform Abstract: DERIVATIVES OF SUCROSE 3′,4′‐EPOXIDE
Authors: GUTHRIE R. D. , JENKINS I. D. , THANG S. , YAMASAKI R. 
Published: May 2016

AbstractDas Epoxid (III) in Form des Hexaacetats kann in vergleichbar guten Gesamtausbeuten entweder aus Sucrose (I) direkt in einer Eintopfreaktion oder aus der Diisopropylidensucrose (IV) oder dem Sucrose‐pentabenzoat (V) hergestellt werden.
ChemInform Abstract: STUDIES ON TETRAHYDROFURYL‐5‐FLUOROURACILS. IV. MODE OF REACTION OF 5‐FLUOROURACIL WITH 2‐ACETOXYTETRAHYDROFURAN
Authors: YAMASHITA J. , YASUMOTO M. , HASHIMOTO S. 
Published: May 2016

AbstractDie ,Kondensation des Fluoruracils (I) mit Acetoxytetrahydrofuran (II) zu dem Tetrahydrofuranyl‐uracil (III) wird mechanistisch untersucht.
ChemInform Abstract: Synthesis and Ionic Conductivity of New High Li Ion Content Garnets, LnSr2Ta2Li7O12 (Ln: La, Pr, Nd, Sm, Gd).
Authors: Howard M. A. , Clemens O. , Parvathy A. S. , Anderson P. A. , Slater P. R. 
Published: May 2016

AbstractSeveral LnSr2Ta2Li7O12 compounds are prepared as ordered tetragonal garnet phase along with a small amount of cubic garnet by firing stoichiometric amounts of the metal oxides and a 20% excess of Li2CO3 (pre‐reacted pellets on ZrO2 in Al2O3 crucible, 850 °C, 14 h).
ChemInform Abstract: Synthesis and Characterization of Copper Hexathiometadiphosphate Cu2P2S6.
Authors: Kuhn Alexander , Schoop Leslie M. , Eger Roland , Lotsch Bettina V. 
Published: May 2016

AbstractThe title compound is synthesized by solid state reaction of stoichiometric mixture of Cu2S and P2S5 (vacuum‐sealed silica tube, 623 K, 24 h).
ChemInform Abstract: MoO2Cl2‐Catalyzed Efficient Synthesis of Functionalized 3,4‐Dihydropyrimidin‐2(1H)‐ones/thiones and Polyhydroquinolines: Recyclability, Fluorescence and Biological Studies.
Authors: Guggilapu Sravanthi Devi , Prajapti Santosh Kumar , Nagarsenkar Atulya , Lalita Guntuku , Naidu Vegi Ganga Modi , Babu Bathini Nagendra 
Published: May 2016

AbstractThe title compounds are prepared by Biginelli and Hantzsch reactions.
ChemInform Abstract: Functionalizations of Mixtures of Regioisomeric Aryllithium Compounds by Selective Trapping with Dichlorozirconocene.
Authors: Castello‐Mico Alicia , Herbert Simon A. , Leon Thierry , Bein Thomas , Knochel Paul 
Published: May 2016

AbstractLithiation of a variety of substituted arenes gives regioisomeric mixtures of aryllithium intermediates.Transmetalation with a substoichiometric amount of ZrCl2Cp2 transmetalates the least sterically hindered aryllithium intermediate, leaving the more hindered regioisomers for reactions with a variety of electrophiles.
ChemInform Abstract: Diastereoselective Addition of Grignard Reagents to α‐Epoxy N‐Sulfonyl Hydrazones.
Authors: Uteuliyev Maulen M. , Nguyen Thien T. , Coltart Don M. 
Published: May 2016

AbstractThe reaction of α‐epoxy N‐sulfonyl hydrazones with Grignard reagents proceeds with the exception of the tert‐butyl Grignard reagent with high diastereoselectivity to yield β‐hydroxy N‐sulfonyl hydrazones.
ChemInform Abstract: Synthesis of 1H‐Azadienes and Application to One‐Pot Organic Transformations.
Authors: Kwon Yearang , Jeon Mina , Park Jin Yong , Rhee Young Ho , Park Jaiwook 
Published: May 2016

AbstractThe Ru‐catalyzed transformation of allyl azides into 1H‐azadienes is described.
ChemInform Abstract: Transmonocyanoacetylation of Phenylenediamines: A Simple and Efficient Synthesis of Novel N‐(Aminophenyl)‐2‐cyanoacetamides and Their Derivatives.
Authors: Ammar Yousry A. , Abbas Samir Y. , Ghorab Mostafa M. , Al Said Mansour S. 
Published: May 2016

AbstractTreatment of phenylenediamines with cyanoacetylating reagent (II) gives the title compounds (III) of which product (IIIa) is converted with various electrophiles providing N‐functionalized derivatives.
ChemInform Abstract: Amino Group Immobilized on Polyvinyl Alcohol as a Reusable Catalyst for Highly Accelerated N‐Formylation of Amines Using Formic Acid under Solvent‐Free Condition.
Authors: Rezazadeh Soodabeh , Akhlaghinia Batool 
Published: May 2016

AbstractThe catalyst can be reused up to four times without significant loss of activity.
ChemInform Abstract: Cobalt(I)‐Catalyzed CH‐Alkylation of Terminal Olefins, and Beyond.
Authors: Giedyk Maciej , Goliszewska Katarzyna , o Proinsias Keith , Gryko Dorota 
Published: May 2016

AbstractIn the attempted cyclopropanation of terminal olefins with diazo esters using cobalester as catalyst, an unusual sp2 C—H alkylation is observed.
ChemInform Abstract: Pd(II) Trifluoroacetate Complexes Containing Chelating Phosphine Ligands: Synthesis, Structures, and Catalysis.
Authors: Kim Kun‐Woo , Kim Yong‐Joo , Lim Hye Jin , Lee Soon W. 
Published: May 2016

AbstractBiaryls are prepared by Suzuki—Miyaura coupling of aryl bromides and aryl boronic acids using the title palladium complex as highly active catalyst.
ChemInform Abstract: Regio‐ and Chemoselective Kumada—Tamao—Corriu Reaction of Aryl Alkyl Ethers Catalyzed by Chromium under Mild Conditions.
Authors: Cong Xuefeng , Tang Huarong , Zeng Xiaoming 
Published: May 2016

AbstractA broad range of aromatic ethers containing an ortho‐directing imine auxiliary are cross‐coupled in a scalable manner with various aryl and alkyl Grignard reagents.
ChemInform Abstract: Microwave Assisted Facile Synthesis of 1‐Amidoalkyl‐2‐naphthols Catalyzed by Stannous Oxide Nanoparticles.
Authors: Singh Rajesh Kumar , Bala Renu , Kumar Sahil 
Published: May 2016

AbstractThe stannous oxide nanoparticles are an efficient, inexpensive, recyclable and reusable, eco‐friendly heterogenous catalyst.
ChemInform Abstract: Synthesis of Multiply Substituted Polycyclic Aromatic Hydrocarbons by Iridium‐Catalyzed Annulation of Ring‐Fused Benzocyclobutenol with Alkyne Through C—C Bond Cleavage.
Authors: Yu Jiajia , Yan Hong , Zhu Chen 
Published: May 2016

AbstractA unique and expeditious method for the synthesis of polycyclic aromatic hydrocarbons (26 examples) is developed using an unprecedented Ir‐catalyzed intermolecular cyclization of alkynes with ring‐fused benzocyclobutenols (I).
ChemInform Abstract: Access to 3‐Acyl‐(2H)‐indazoles via Rh(III)‐Catalyzed C—H Addition and Cyclization of Azobenzenes with α‐Keto Aldehydes.
Authors: Jeong Taejoo , Han Sang Hoon , Han Sangil , Sharma Satyasheel , Park Jihye , Lee Jong Suk , Kwak Jong Hwan , Jung Young Hoon , Kim In Su 
Published: May 2016

AbstractSymmetrically substituted azobenzenes react with ethyl glyoxalate, and depending on the electronic properties of the aryl substitutents either a single or a mixture of two indazole products is formed.
ChemInform Abstract: Three‐Component Reaction Between Substituted 2‐(2‐Nitrovinyl)‐phenols, Acetylenedicarboxylate and Amines: Diversity‐Oriented Synthesis of Novel Pyrrolo[3,4‐c]coumarins.
Authors: Xue Shuwen , Yao Juan , Liu Jiaming , Wang Lizhong , Liu Xinyu , Wang Cunde 
Published: May 2016

AbstractThis reaction involves the sequential iron trichloride‐mediated nucleophilic addition followed by intramolecular transesterification and intramolecular nucleophilic addition reaction.
ChemInform Abstract: Direct, Regioselective N‐Alkylation of 1,3‐Azoles.
Authors: Chen Shuai , Graceffa Russell F. , Boezio Alessandro A. 
Published: May 2016

Abstract1,3‐Azoles and various derivatives thereof, including substituted 1,3‐benzodiazoles, purines, and imidazopyridines, are efficiently alkylated following a protecting group‐free strategy.
ChemInform Abstract: Synergistic Promoting Effect of Ball Milling and KF—Alumina Support for the Green Synthesis of Benzothiazinones.
Authors: Sharifi Ali , Ansari Mohammad , Darabi Hossein Reza , Abaee M. Saeed 
Published: May 2016

AbstractA solvent‐free reaction of 2‐aminothiophenols with 2‐bromoalkanoates provides benzothiazinones in good to excellent yields using alumina‐supported KF in combination with ball milling.
ChemInform Abstract: Green and Reusable Nanocatalyst for the Synthesis of 1,5‐Benzodiazepines and Its Derivatives under Solvent‐Free Conditions.
Authors: Satyanarayana Kandregula Veera Venkata , Chandra Matangi Ravi , Ramaiah Parimi Atchuta , Murthy Yellajyosula Lakshmi Narasimha , Gil Yoon Soon , Pammi Sri Venkata Narayana 
Published: May 2016

AbstractCdS nanoparticles show superior catalytic activity for the synthesis of benzodiazepines by condensation of o‐phenylenediamine with ketones under solvent‐free conditions.
ChemInform Abstract: Late Stage C—H Activation of a Privileged Scaffold; Synthesis of a Library of Benzodiazepines.
Authors: Khan Raysa , Felix Robert , Kemmitt Paul D. , Coles Simon J. , Day Iain J. , Tizzard Graham J. , Spencer John 
Published: May 2016

AbstractRegioselective direct ortho‐arylation of the phenyl group is achieved using diaryliodonium tetrafluoroborates as the reactant and Pd(II) acetate as the catalyst under microwave irradiation.
ChemInform Abstract: A Study of Luminescence from Eu3+, Ce3+, Tb3+ and Ce3+/Tb3+ in New Potassium Gadolinium Phosphate K3Gd5(PO4)6.
Authors: Meng Fangui , Zhang Hongzhi , Chen Cuili , Kim Sun Il , Seo Hyo Jin , Zhang Xinmin 
Published: May 2016

AbstractThe new phosphors K3Gd5(PO4)6 doped with Eu3+, Ce3+, or Tb3+ and co‐doped with Ce3+ and Tb3+ are prepared by solid state reactions of K2CO3, Gd2O3, NH4H2PO4, Eu2O3, CeO2, and Tb4O7 (600 °C for 2 h and 850 °C for 5 h).
Prognostic impact of a 3‐MicroRNA signature in cytological samples of small cell lung cancer
Authors: Mancuso Giuseppe , Bovio Enrica , Rena Ottavio , Rrapaj Eltjona , Mercalli Francesca , Veggiani Claudia , Paganotti Alessia , Andorno Silvano , Boldorini Renzo 
Published: May 2016

BACKGROUNDSmall cell lung cancer (SCLC) is a highly aggressive neoplasm that accounts for approximately 10% to 15% of lung cancers. In most cases, the diagnosis relies on cytology and needs to be confirmed by immunohistochemistry. Although several genetic and molecular abnormalities have been recorded, molecular markers able to predict the prognosis are still lacking. MicroRNA (miRNA) signatures have been recently proposed as useful biomarkers in lung cancer because of their high stability during standard sample processing.METHODSCytological samples for 50 patients with SCLC were collected from primary tumors (n = 25) and metastases (n = 25) by means of fine‐needle aspiration (FNA) or bronchial washing (BW); they were fixed in ethanol (FNA) or Duboscq‐Brazil fluid (BW). The 3‐miRNA panel expression (miR‐192, miR‐200c, and miR‐205) was quantified with a TaqMan polymerase chain reaction miRNA assay and was compared with overall survival (OS) and clinicopathological data.RESULTSAll samples had sufficient RNA for the miRNA expression analysis to be performed, regardless of the sample source or the fixative medium. Patients with a low expression level of the 3‐miRNA panel were associated with better OS in univariate (P = .032) and multivariate analyses (P = .022). Moreover, in the group of patients older than the mean age of our cohort (65.8 years), a significant OS advantage (P = .013) was seen for patients with a low expression level of the 3‐miRNA panel.CONCLUSIONSA specific 3‐miRNA signature is potentially useful for predicting survival for patients with SCLC, and it may be feasible with cytological samples taken during standard diagnostic procedures. Cancer Cytopathol 2016;124:621–9. © 2016 American Cancer Society.
Balancing push and pull in Confuga, an active storage cluster file system for scientific workflows
Authors: Donnelly Patrick , Thain Douglas 
Published: May 2016

SummaryMost big‐data analysis systems require users to adopt restricted abstractions to achieve scaling and system stability. While highly effective at establishing data locality and eliminating interdependencies, this approach is not easily incorporated into scientific workflows that are often complex and irregular graphs of sequential programs with multiple dependencies. To address this, we have developed an active storage cluster file system named Confuga which harnesses the file information already available in the workflow to enable efficient and controlled distribution of dependencies across active storage nodes. Confuga is built upon the idea of leveraging a job's namespace to eliminate unknown transfers and to plan the replication of all job dependencies. Replication is carried out through two opposing transfer methodologies: centrally managed push transfers and distributed pulls. We evaluate the effectiveness of the two transfer mechanisms using workflows that stress the ability of the cluster to replicate dependencies. Ultimately, we show that a balance of the two approaches achieves optimal file distribution. This is shown in two bioinformatics workflows where a careful balance of the two mechanisms leads to 48% and 77% improvements over only push or pull. Copyright © 2016 John Wiley & Sons, Ltd.