bluuebunny/crossref_metadata_2025_split huggingface dataset:
Educational and wealth inequalities in tobacco use among men and women in 54 low-income and middle-income countries
Authors: Sreeramareddy Chandrashekhar T , Harper Sam , Ernstsen Linda 
Published: November 2016

BackgroundSocioeconomic differentials of tobacco smoking in high-income countries are well described. However, studies to support health policies and place monitoring systems to tackle socioeconomic inequalities in smoking and smokeless tobacco use common in low-and-middle-income countries (LMICs) are seldom reported. We aimed to describe, sex-wise, educational and wealth-related inequalities in tobacco use in LMICs.MethodsWe analysed Demographic and Health Survey data on tobacco use collected from large nationally representative samples of men and women in 54 LMICs. We estimated the weighted prevalence of any current tobacco use (including smokeless tobacco) in each country for 4 educational groups and 4 wealth groups. We calculated absolute and relative measures of inequality, that is, the slope index of inequality (SII) and relative index of inequality (RII), which take into account the distribution of prevalence across all education and wealth groups and account for population size. We also calculated the aggregate SII and RII for low-income (LIC), lower-middle-income (lMIC) and upper-middle-income (uMIC) countries as per World Bank classification.FindingsMale tobacco use was highest in Bangladesh (70.3%) and lowest in Sao Tome (7.4%), whereas female tobacco use was highest in Madagascar (21%) and lowest in Tajikistan (0.22%). Among men, educational inequalities varied widely between countries, but aggregate RII and SII showed an inverse trend by country wealth groups. RII was 3.61 (95% CI 2.83 to 4.61) in LICs, 1.99 (95% CI 1.66 to 2.38) in lMIC and 1.82 (95% CI 1.24 to 2.67) in uMIC. Wealth inequalities among men varied less between countries, but RII and SII showed an inverse pattern where RII was 2.43 (95% CI 2.05 to 2.88) in LICs, 1.84 (95% CI 1.54 to 2.21) in lMICs and 1.67 (95% CI 1.15 to 2.42) in uMICs. For educational inequalities among women, the RII varied much more than SII varied between the countries, and the aggregate RII was 14.49 (95% CI 8.87 to 23.68) in LICs, 3.05 (95% CI 1.44 to 6.47) in lMIC and 1.58 (95% CI 0.33 to 7.56) in uMIC. Wealth inequalities among women showed a pattern similar to that of men: the RII was 5.88 (95% CI 3.91 to 8.85) in LICs, 1.76 (95% CI 0.80 to 3.85) in lMIC and 0.39 (95% CI 0.09 to 1.64) in uMIC. In contrast to men, among women, the SII was pro-rich (higher smoking among the more advantaged) in 13 of the 52 countries (7 of 23 lMIC and 5 of 7 uMIC).InterpretationOur results confirm that socioeconomic inequalities tobacco use exist in LMIC, varied widely between the countries and were much wider in the lowest income countries. These findings are important for better understanding and tackling of socioeconomic inequalities in health in LMIC.
Disruption of Autophagic Degradation with ROC-325 Antagonizes Renal Cell Carcinoma Pathogenesis
Authors: Carew Jennifer S. , Espitia Claudia M. , Zhao William , Han Yingchun , Visconte Valeria , Phillips James , Nawrocki Steffan T. 
Published: November 2016

Abstract
Purpose: Although autophagy plays important roles in malignant pathogenesis and drug resistance, there are few clinical agents that disrupt this pathway, and the potential therapeutic benefit of autophagy inhibition remains undetermined. We used medicinal chemistry approaches to generate a series of novel agents that inhibit autophagic degradation.
Experimental Design: ROC-325 was selected as a lead compound for further evaluation. Comprehensive in vitro and in vivo studies were conducted to evaluate the selectivity, tolerability, and efficacy of ROC-325 in preclinical models of renal cell carcinoma (RCC) with HCQ serving as a comparator. Markers of autophagy inhibition and cell death were evaluated in tumor specimens.
Results: ROC-325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. Focused studies of the mechanism of action and efficacy of ROC-325 in RCC cells showed that drug treatment induced hallmark characteristics of autophagy inhibition, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux. Subsequent experiments showed that ROC-325 antagonized RCC growth and survival in an ATG5/7-dependent manner, induced apoptosis, and exhibited favorable selectivity. Oral administration of ROC-325 to mice bearing 786-0 RCC xenografts was well tolerated, was significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.
Conclusions: Our findings demonstrate that ROC-325 has superior preclinical anticancer activity compared with HCQ and support the clinical investigation of its safety and preliminary efficacy in patients with RCC and other autophagy-dependent malignancies. Clin Cancer Res; 23(11); 2869–79. ©2016 AACR.
An miRNA–DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia
Authors: Solly Françoise , Koering Catherine , Mohamed Aminetou Mint , Maucort-Boulch Delphine , Robert Guillaume , Auberger Patrick , Flandrin-Gresta Pascale , Adès Lionel , Fenaux Pierre , Kosmider Olivier , Tavernier-Tardy Emmanuelle , Cornillon Jérôme , Guyotat Denis , Campos Lydia , Mortreux Franck , Wattel Eric 
Published: November 2016

AbstractPurpose: Azacitidine inhibits DNA methyltransferases, including DNMT1, and is currently the standard of care for patients with higher-risk myelodysplastic syndrome (HRMDS) or low blast count acute myeloid leukemia (AML).Experimental Design: The expression of 754 miRNAs was compared in azacitidine-resistant and azacitidine-sensitive myelodysplastic syndrome cells. We investigated the role of differentially expressed miRNAs on DNMT1 expression and azacitidine resistance in vitro. We next evaluated anti-DNMT1 miRNA expression in pretreatment bone marrow samples derived from 75 patients treated with azacitidine for HRMDS or AML.Results: Seven miRNAs, including 5 that in silico targeted the DNMT1 3′ UTR, were repressed in azacitidine-resistant cells in which DNMT1 protein levels were significantly higher. Ectopic anti-DNMT1 miRNA expression decreased DNMT1 expression and increased azacitidine sensitivity, whereas specific inhibition of endogenous anti-DNMT1 miRNAs increased DNMT1 expression and triggered azacitidine resistance. In patients treated with azacitidine, decreased expression of anti-DNMT1 miRNAs was associated with poor outcome. miR-126* had the strongest prognostic impact. Patients with miR-126*low myelodysplastic syndrome had significantly lower response rates (P = 0.04) and higher relapse rates (P = 0.03), as well as shorter progression-free (PFS; P = 0.004) and overall survival (OS; P = 0.004). Multivariate analysis showed that age, miR-126* expression, and revised International Prognostic Scoring System risk independently predicted PFS and OS. In 15 patient samples collected over time, decreased miRNA expression levels were associated with secondary resistance.Conclusions: A decreased expression of anti-DNMT1 miRNAs might account for azacitidine resistance in HRMDS and AML, and measuring miRNA expression before and during treatment might help predict primary or secondary azacitidine resistance. Clin Cancer Res; 23(12); 3025–34. ©2016 AACR.
Records of Cigaritis zhengweilie Huang, 1998 (Lepidoptera: Theclinae) from Arunachal Pradesh, India and southeastern Tibet, China, and a note on Cigaritis elwesi (Evans, [1925])
Authors: Roy Purnendu 
Published: November 2016

A specimen of Cigaritis zhengweilie Huang (1998) collected from Anini, Upper Dibang Valley District, Arunachal Pradesh, India is recorded and illustrated together with a paratype of Cigaritis zhengweilie chayuensis from Chayu county, southeastern Tibet. Brief diagnostic notes on seperating this species from Cigaritis syama and Cigaritis nipalicus. A note on Cigaritis elwesi.
Foraging of the Indian Short-nosed Fruit Bat Cynopterus sphinx on banana in shops and on the pieces dropped by monkeys at a temple
Authors: Rathinakumar A. , Baskaran S. , Marimuthu G. 
Published: November 2016

The Indian Short-nosed Fruit Bat Cynopterus sphinx fed on the pieces of banana fruit that were dropped by monkeys on the tower of a temple and in nearby shops. The monkeys obtained fruits from devotees and shop owners. The peak number of bat visits occurred during pre- and post- midnight hours at the tower and shops, respectively, coinciding with the lights off situation and reduced human disturbance. The bats landed on bunches of ripe bananas hanging in the front of shops. The number of bat landings on the tower was greater than that in the shops. The overall number of bat visits were higher during October when compared to other periods of the year. This may be due to the occurrence of more festivals during October. Our study is an example of opportunistic feeding, in which banana pieces dropped while monkeys were feeding on them were eaten by the bats.
An occurrence of the rare Sharptail Mola Masturus lanceolatus (Lienard, 1840) (Tetraodontiformes: Molidae), in the coastal waters of Visakhapatnam, India
Authors: Naranji Muddula Krishna , Rao Velamala Govinda , Venu Devara 
Published: November 2016

A single specimen of the Sharptail Mola Masturus lanceolatus (Lienard, 1840) (total length 1.39m) was collected from a commercial trawler operated from Visakhapatnam at a depth range of 150–300 m, east coast of India on 12 April 2016. It was recorded for the first time in Visakhapatnam. A detailed description, morphometric and meristic characters of the species are provided in this paper
The status of the Brahminy Starling Sturnia pagodarum (Gmelin, 1789) (Aves: Passeriformes: Sturnidae) in Southeast Asia
Authors: Naing Soe , Paw Nah Lah Pwai , Lanzinger Beatrix , Soisook Pipat , Pearch Malcolm J. , Bates Paul J.J. 
Published: November 2016

To date, the status of the Brahminy Starling Sturnia pagodarum, in Southeast Asia has been unclear. The origins of the few reported sightings, where commented upon, have often been listed as ‘uncertain’ or ‘unknown’ with the implication that some, maybe all, are escaped captivity birds. The current paper brings together data on distribution, date of observation, and number of individuals to illustrate a pattern that clearly supports the view that records from Myanmar, Thailand, Malaysia, and Singapore should be treated as ‘winter vagrants’. With one exception, they are all of five birds or less and have been observed from October to March. The paper includes the first authenticate record from Myanmar, which is the 1115th wild bird species listed for the country. However, the status of a single record from Cambodia is treated with caution since it represents a considerable range extension and was observed on 01 April, which is relatively late in the season. For these reasons, it is here listed as ‘origin uncertain’ until further data are available.
Dipcadi krishnadevarayae (Asparagaceae), a new plant species from Andhra Pradesh, India
Authors: Rao Boyina Ravi Prasad , Prasad Kothareddy , Veeranjaneyulu Dasari , Naik Mudavath Chennakesavulu , Salamma Sugali , Narayanaswamy Angajala 
Published: November 2016

Dipcadi krishnadevarayae B.R.P.Rao (Asparagaceae), a new species from the Sri Krishnadevaraya University campus, Anantapuramu of Andhra Pradesh, India, is described and illustrated. The novel species is distinct from all other species of Dipcadi in having distinctly 6-lobed stigma and shows close affinity to D. serotinum (L.) Medik. and D. montanum (Dalzell) Baker. It differs from both allies in having a combination of up to 50cm long linear leaves, 85cm long 16–24 flowered scapes, greenish-yellow flowers, dark green band outside the outer tepals, distinctly 6-lobed stigma and up to 10 seeds in each locule.
Parasitization of a huntsman spider (Arachnida: Araneae: Sparassidae: Heteropoda venatoria) by a mermithid nematode (Nematoda: Mermithidae)
Authors: Ranade Sachin P. , Prakash Vibhu 
Published: November 2016

The emergence of a mermithid worm from a huntsman spider Heteropoda venatoria was witnessed at Buxa Tiger Reserve, West Bengal. It appears to be a first record of the spider family Sparassidae serving as a host for a member of the family Mermithidae.
Catalogue of the family Ologamasidae Ryke (Acari: Mesostigmata)
Authors: CASTILHO RAPHAEL C. , SILVA EDMILSON S. , DE MORAES GILBERTO J. , HALLIDAY BRUCE 
Published: November 2016

Mites of the family Ologamasidae are very conspicuous and abundant in soil and litter, especially in the Southern Hemisphere. Little is known of their biology and behaviour, but they appear to be generalist predators. The family is placed in the Rhodacaroidea, but its status and composition have been very unstable. The existing classification and identification keys are obsolete and difficult to use. We present a historical review of the literature on the classification of the Ologamasidae, with revised diagnoses for the family and its included genera, and a new key to genera. We also present a complete catalogue of the species, with details of their nomenclature and bibliography, and a summary of the locality and habitat data for the types for each species. The family includes a total of 467 species arranged in 44 genera. The largest genera are Gamasiphis Berlese (74 species), Gamasellus Berlese (70 species) and Geogamasus Lee (33 species). These three genera together include more than 35% of the valid species in the family. Seven of the genera are monotypic. We list a further 29 species that appear to belong to the family Ologamasidae, but which cannot be confidently assigned to a genus on the basis of the available information. We also list 74 species that have been placed in the Ologamasidae at some time, but which are now placed in other families, especially the Veigaiidae, Digamasellidae, Parasitidae, and Eviphididae. New combinations are proposed for 15 species. The genus Pachymasiphis is described as new, because this name was not made available correctly when it was first proposed.
Czy jesteśmy „ludzkim zoo”?
Authors: Wrzesińska Katarzyna 
Published: November 2016

Are we "human zoo"?Review: The Invention of Race. Scientific and Popular Representation, N. Bancel, T. David, D. Thomas (ed.), Routlege: New York-Abington, 2014, ss. 320.The book under review is a collection of articles presenting the functioning of the idea of the human race in the scientific, social and cultural backgrounds. The main purpose is to demonstrate how the concept of race have circulated from the late 18th century in scholarship as well as in popular reception. Thus the authors focus their attention on the so-called ethnological expositions (such as Negro or Eskimo Villages) organized on the occasion of world‘s fairs, today known as “human zoo.” On the social level, this helped support the conviction of the supremacy of the white race. Czy jesteśmy „ludzkim zoo”?Recenzja: The Invention of Race. Scientific and Popular Representation, N. Bancel, T. David, D. Thomas (ed.), Routlege: New York-Abington, 2014, ss. 320.Recenzowana praca zawiera zbiór artykułów poświęconych przedstawieniu funkcjonowania koncepcji podziału ludzkości na rasy na szerokim tle: naukowym, społecznym i kulturowym. Główny cel stanowi zobrazowanie procesu cyrkulacji idei rasy – od ujęć naukowych począwszy od końca XVIII w. aż do ukazania problemu na płaszczyźnie odbioru masowego. Tu obiektem zainteresowań badawczych stały się tzw. ekspozycje etnologiczne (np. wioski murzyńskie, eskimoskie) organizowane przy okazji wystaw światowych, określane dzisiaj mianem „ludzkich zoo”. Płaszczyzna ta przyczyniła się do utrwalenia w świadomości społecznej poczucia supremacji białej rasy.
Cross-cultural school-based encounters as global health education
Authors: Bruselius-Jensen Maria , Renwick Kerry , Aagaard-Hansen Jens 
Published: November 2016

Objective: Drawing on the concepts of the cosmopolitan person and democratic health education, this article explores the merits of primary school–based, cross-cultural dialogues for global health education. Design: A qualitative study of the learning outcomes of the Move|Eat|Learn (MEL) project. MEL facilitates cultural meetings, primarily Skype-based, between students from Kenya and Denmark, with the aim of promoting reflection on differences and similarities in everyday living conditions and their impact on health practices. Setting: Three Danish and one Kenyan primary schools. Methods: Qualitative analysis of 18 focus group discussions with 72 Danish and 36 Kenyan students. Results: Cross-cultural dialogues promoted students’ engagement and reflections on their own and peers’ health condition, access to education, food cultures, gender and family structures. Conclusion: Findings indicate the merits of cross-cultural dialogues as a means of educating students to become global health agents with a cosmopolitan outlook.
Th17 cell frequency and IL-17A concentrations in peripheral blood mononuclear cells and vitreous fluid from patients with diabetic retinopathy
Authors: Chen Hui , Ren Xiangrong , Liao Nanying , Wen Feng 
Published: November 2016

Objective To quantify T helper (Th)17 cells and determine interleukin (IL)-17A levels in peripheral blood mononuclear cell (PBMC) culture and vitreous fluid from patients with type 2 diabetes mellitus (T2DM) with diabetic retinopathy (DR). Methods Th17 cell frequency and IL-17A concentrations in PBMCs from 60 patients with T2DM with DR, 30 without DR and 30 sex- and age-matched healthy individuals were measured by flow cytometry and enzyme-linked immunosorbent assay (ELISA), respectively. IL-17A levels in vitreous fluid from 31 eyes with proliferative DR and diabetic macular oedema (DR group) and 32 eyes with an epiretinal membrane and macular hole (control group) that underwent vitrectomy were also examined by ELISA. Results Compared with the control group, the proportion of Th17 cells and IL-17A concentrations in PBMCs were significantly increased in patients without DR but decreased in those with DR. IL-17A concentrations and Th17 cell frequency in PBMCs tended to decrease with DR severity and were negatively correlated with body mass index, T2DM duration and glycated haemoglobin. Additionally, vitreous fluid IL-17A levels were significantly elevated in patients with DR compared with those of the control group. Conclusions We conclude that disturbances in Th17 cells and IL-17A levels are possibly associated with DR.
Pro-nociceptive migraine mediator CGRP provides neuroprotection of sensory, cortical and cerebellar neurons via multi-kinase signaling
Authors: Abushik Polina A , Bart Geneviève , Korhonen Paula , Leinonen Hanna , Giniatullina Raisa , Sibarov Dmitry A , Levonen Anna-Liisa , Malm Tarja , Antonov Sergei M , Giniatullin Rashid 
Published: November 2016

Background Blocking the pro-nociceptive action of CGRP is one of the most promising approaches for migraine prophylaxis. The aim of this study was to explore a role for CGRP as a neuroprotective agent for central and peripheral neurons. Methods The viability of isolated rat trigeminal, cortical and cerebellar neurons was tested by fluorescence vital assay. Engagement of Nrf2 target genes was analyzed by qPCR. The neuroprotective efficacy of CGRP in vivo was tested in mice using a permanent cerebral ischemia model. Results CGRP prevented apoptosis induced by the amino acid homocysteine in all three distinct neuronal populations. Using a set of specific kinase inhibitors, we show the role of multi-kinase signaling pathways involving PKA and CaMKII in neuronal survival. Forskolin triggered a very similar signaling cascade, suggesting that cAMP is the main upstream trigger for multi-kinase neuroprotection. The specific CGRP antagonist BIBN4096 reduced cellular viability, lending further support to the proposed neuroprotective function of CGRP. Importantly, CGRP was neuroprotective against permanent ischemia in mice. Conclusion Our data show an unexpected ‘positive’ role for the endogenous pro-nociceptive migraine mediator CGRP, suggesting more careful examination of migraine prophylaxis strategy based on CGRP antagonism although it should be noted that homocysteine induced apoptosis in primary neuronal cell culture might not necessarily reproduce all the features of cell loss in the living organism.
Effectiveness of mycophenolate mofetil as first-line therapy in AQP4-IgG, MOG-IgG, and seronegative neuromyelitis optica spectrum disorders
Authors: Montcuquet Alexis , Collongues Nicolas , Papeix Caroline , Zephir Helene , Audoin Bertrand , Laplaud David , Bourre Bertrand , Brochet Bruno , Camdessanche Jean-Philippe , Labauge Pierre , Moreau Thibault , Brassat David , Stankoff Bruno , de Seze Jerome , Vukusic Sandra , Marignier Romain ,   on behalf of NOMADMUS study group and the Observatoire Français de la Sclérose en Plaques (OFSEP)
Published: November 2016

Objective: To evaluate the effectiveness and tolerance of mycophenolate mofetil (MMF) as a first-line treatment in neuromyelitis optica spectrum disorder (NMOSD). Methods: In all, 67 NMOSD patients treated by MMF as first-line therapy, from the NOMADMUS cohort were included. A total of 65 fulfilled 2015 NMOSD criteria, and 5 were myelin oligodendrocyte glycoprotein (MOG)-immunoglobulin G (IgG) positive. Effectiveness was evaluated on percentage of patients continuing MMF, percentage of patients free of relapse, pre- and post-treatment change in the annualized relapse rate (ARR), and Expanded Disability Status Scale (EDSS). Results: Among 67 patients, 40 (59.7%) continued treatment till last follow-up. A total of 33 (49.3%) were relapse-free. The median ARR decreased from one pre-treatment to zero post-treatment. Of 53 patients with complete EDSS data, the score improved or stabilized in 44 (83%; p < 0.05). Effectiveness was observed in aquaporin-4 (AQP4)-IgG (57.8% continued treatment, 46.7% relapse-free), MOG-IgG (3/5 continued treatment, 4/5 relapse-free), and seronegative NMOSD (64.7% continued treatment, 61.3% relapse-free). In 16 patients with associated steroids, 13 (81.2%) continued MMF till last follow-up versus 15 of 28 (53.6%) in the non-steroid group. Nine patients discontinued treatment for tolerability purpose. Conclusion: MMF showed effectiveness and good tolerability as a first-line therapy in NMOSD, whatever the AQP4-IgG status. Concomitant use of oral steroids at start could limit the risk of treatment failure.
Intrapulmonary Percussive Ventilation as a Lung Recruitment Strategy in Brain-Dead Organ Donors
Authors: Lerg Geralyn , Shanta Linda 
Published: November 2016

Objective: To determine the strength of the evidence evaluating the effectiveness of intrapulmonary percussive ventilation (IPV) as a safe alternative or adjunctive therapy to traditional chest physiotherapy (CPT) among potential organ donors. Data Sources: Literature search conducted from February 2015 to November 2015 using PubMed, Cumulative Index of Nursing and Allied Health Literature, Scopus, and bibliographies of pertinent articles. Search Terms: Intrapulmonary percussive ventilation, chest physiotherapy, chest wall oscillation, organ donors, and ventilation. Study Selection: Articles in English from 1994 to present directly compared IPV to CPT or conventional (no) therapy. Data Extraction: Association of Critical-Care Nurses Levels of Evidence was used to determine the strength of evidence. Level B and level C articles were reviewed. Data Synthesis: No studies were found using IPV in the donor population. Results from studies using IPV in other populations indicated IPV had no adverse effects, improved sputum clearance and oxygenation, and reduced atelectasis and pneumonia in patients with artificial airways. Conclusion: Intrapulmonary percussive ventilation may be a safe and effective alternative or adjunctive to CPT therapy and improve the number of lungs available for transplantation. Clinical research is essential to determine the effectiveness of this therapy for lung recruitment in the donor population.