bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study in Erythromelalgia
Authors: Jelinek V. M. J. 
Published: September 2017

SummaryErythromelalgia is a condition characterized by redness and burning pains in the limbs occurring as a response to a rise of limb temperature. In the past, it has been treated by a number of drugs, none of which has been particularly effective. In this study, an electric blanket was used to produce a rise of limb temperature and development of pain in a 25 year old man who had been disabled by primary erythromelalgia. 10 drugs of known vaso‐active or anti‐inflammatory properties were tested by this method without affecting the pain experienced by the patient. Despite these findings, a pilot clinical study suggested that when used in combination, methysergide 2 mg t.d.s. and ephedrine 60 mg t.d.s. could prevent the occurrence of the patient's symptoms. However, owing to the known toxicity of methysergide, a test was sought which could demonstrate an objective effect of this agent before continuing its use in combination. Further testing with an electric blanket did not confirm its efficacy, but testing with a bicycle ergometer did demonstrate therapeutic benefit of both methysergide and its combination with ephedrine. After nine months successful use of the methysergide and ephedrine combination, it was found that methysergide could be deleted with minimal aggravation of the condition. A review of the clinical features of erythromelalgia suggests that this phenomenon may be due to kinins liberated by a rise of limb temperature in predisposed subjects.
Progressive Systemic Sclerosis (Scleroderma)
Authors: Tay Chong Hai , Khoo Oon Teik 
Published: September 2017

SummarySixteen cases of progressive systemic sclerosis (PSS) were studied in a large general hospital in Singapore from 1957 to 1967. Thirteen were Chinese and 3 Malays. The majority were middle‐aged housewives and half of the cases were seen less than six months after onset. A comparison of clinical features of this series and those from western countries was made. The pattern of cutaneous sclerosis was different and there was notable diminished incidence of Raynaud's phenomenon and associated secondary skin lesions. On the other hand, gastric and duodenal involvements seemed to be more common. A high percentage of cases had mild to moderate albuminuria without any other evidence of renal damage. The laboratory findings were similar to other western series, but with a low incidence of rheumatoid arthritis factor and antinuclear antibodies. Although steroids were given, the majority remained clinically unchanged. The prognosis for the chronic type of PSS is good.
Urinary Excretion and Plasma Levels of Sulphonamides in Patients with Renal Impairment
Authors: Adam W. R. , Dawborn J. K. 
Published: September 2017

SummaryUrine and plasma levels and the clearance of two sulphonamides have been studied in patients with varying degrees of renal failure. In patients with renal impairment there is a decreased sulphadiazine clearance and a reduced 24 hour excretion after a single intravenous dose of sulphadiazine.In 4 patients on 7 occasions on continuous sulphadiazine or sulphamethizole therapy for three days there was an accumulation in the plasma of free and conjugated sulphonamide. In three of these patients elevated sulphonamide levels were associated with toxic side effects.Urine concentrations of free sulphonamide were much reduced in patients with renal impairment. Low urine concentrations and high plasma levels limit the use of sulphonamides in patients with renal damage.
Leber's Optic Atrophy: A Possible Example of Vertical Transmission of a Slow Virus in Man
Authors: Wallace D. C. 
Published: September 2017

SummaryIt is demonstrated that the unusual form of inheritance seen in Leber's disease could be due to the presence of a slow virus acting upon individuals with a variable and partly inherited resistance to the infection. A study of a family afflicted by Leber's disease has demonstrated a pattern strongly suggestive of vertical (i.e. parent‐child) transmission of a slow viral agent with late neurological effects.
The Activated Partial Thromboplastin Time in the Control of Heparin Treatment
Authors: Hirsh J. , O'Sullivan E. F. , Gallus A. S. , Martin M. 
Published: September 2017

SummaryThe effect of heparin on the activated partial thromboplastin time and whole blood clotting time was measured in 30 patients with thrombo‐embolic disease. In 27 of these patients there was good correlation between the results of the two tests. Three patients showed little change of the activated partial thromboplastin time, although the clotting time was prolonged by heparin. It is uncertain at present which of these two tests provides the better measure of the antithrombotic effects of heparin when such a discrepancy exists. However, the activated partial thromboplastin time is more convenient to perform and we consider it to be the more suitable test for the routine control of heparin therapy.
Xanthomatous Tumour of the Lung with Identification of Lipid Content
Authors: Long Frank L. , Nott D. B. , MacArthur E. B. 
Published: September 2017

SummaryA case of benign xanthomatous tumour of the lung presenting with haemoptysis in a woman aged 49 years is described.Histochemical studies were carried out to determine the nature of the lipids present within the tumour and these were found to be cholesterol and cholesterol esters. The xanthoma cells were considered to be the result of macrophage response to haemorrhage.
Information from social networking sites: Context collapse and ambiguity in the hiring process
Authors: Pike Jacqueline C. , Bateman Patrick J. , Butler Brian S. 
Published: September 2017

AbstractForming impressions of job candidates is a challenging process, one characterized by ambiguity brought about by the uncertainty associated with making decisions and judgments. To reduce ambiguity, hiring professionals have established policies and procedures to facilitate the sourcing and use of information about a candidate. However, recently, a public source of information is increasingly being used—information from social networking sites (SNSs). While conventional wisdom says more information is better and can help make decisions less ambiguous, this relationship may not be as straightforward as expected when facing assessments of candidates. This paper examines two such aspects, information‐task quality and context collapse, and their collective impact on ambiguity when making an assessment of a job candidate. Using data from an online survey‐based experiment, the findings suggest information from SNSs can be useful, yet can create ambiguity for decision makers because of context collapse made possible by SNS technologies.
Ayni Real and Imagined: Reciprocity, Indigenous Institutions, and Development Discourses in Contemporary Bolivia
Authors: Wutich Amber , Beresford Melissa , Carvajal Cinthia 
Published: September 2017

ResumenDurante la última década hubo un cambio muy grande en las políticas bolivianas, demarcado por el rechazo a los gobiernos neoliberales y un incremento del activismo indígena. Ayni (“reciprocidad,” quechua) representa nuevas posibilidades para un naciente orden económico. Exploramos el papel que las ONGs tienen en la promoción del ayni como una forma alternativa de desarrollo. Extrayendo de un análisis histórico de ayni, examinamos encuentros y desencuentros entre la retórica en ayni utilizada por ONGs y la realidad de la reciprocidad practicada en comunidades. Encontramos que los discursos de las ONGs sobre ayni, primero, amplían y debilitan el concepto, y segundo, re‐conciben ayni en formas más compatibles con practicas nuevas de reciprocidad vinculadas a la comercialización y reevangelización. Concluimos que ayni ayuda a las ONGs a encontrar un balance entre diferentes corrientes de cambio social–económico, político y religioso–que han cambiado profundamente a Bolivia en los últimos 30 años.
Optimal management of two ecologically interacting deer species—reality matters, beliefs don't
Authors: Elofsson Katarina , Mensah Justice Tei , Kjellander Petter 
Published: September 2017

AbstractThe aim of this paper is to analyze the optimal management of two ecologically interdependent, competing species, roe deer (Capreolus capreolus) and fallow deer (Dama dama). To this end, we develop a numerical stage‐structured model, accounting for species‐specific life history characteristics, gender, and stage‐specific hunting values. Two contrasting management regimes are considered: optimal joint management of the two species and management where the decision maker is ignorant about interspecific competition. Results from our case study show that the presence of interspecific competition reduces roe deer population size and harvest by 30% and 47%, respectively, and reduces the net present value by 9%. High interspecific competition could lead to the exclusion of the roe deer from the area. In contrast, ignorance about the level and consequences of interspecific competition has no impact on harvest decisions and revenues. The explanation is the higher hunting benefits for fallow deer.Summary for Managers
Wildlife managers need bioeconomic models for decisions on ecologically interdependent species.
This study investigates optimal joint management of roe and fallow deer when the fallow deer exerts a negative impact on roe deer due to interspecific competition.
Results show that interspecific competition reduces the net present value of hunting at the study site by 9%.
Regulations will not increase the net present value of hunting in a situation where the manager is ignorant of interspecific competition.
Documentation of heritage buildings using close‐range UAV images: dense matching issues, comparison and case studies
Authors: Murtiyoso Arnadi , Grussenmeyer Pierre 
Published: September 2017

AbstractThree‐dimensional (3D) documentation of heritage buildings has long employed both image‐based and range‐based techniques. Unmanned aerial vehicles (UAVs) provide a particular advantage for image‐based techniques in acquiring aerial views, which are difficult to attain using classical terrestrial‐based methods. The technological development of optical sensors and dense matching algorithms also complement existing photogrammetric workflows for the documentation of heritage objects. In this paper, fundamental concepts in photogrammetry and 3D reconstruction based on structure from motion (SfM) will be briefly reviewed. Two case studies were performed using two types of UAVs, one being a state‐of‐the‐art platform dedicated to obtaining close‐range images. Comparisons with laser scanning data were performed and several issues regarding the aerial triangulation and dense matching results were assessed. The results show that although the dense matching of these UAV images may generate centimetre‐level precision, a further increase in precision is often hampered by the quality of the onboard sensor.
Complete Genome Sequence of
Dehalobacterium formicoaceticum
Strain DMC, a Strictly Anaerobic Dichloromethane-Degrading Bacterium
Authors: Chen Gao , Murdoch Robert W. , Mack E. Erin , Seger Edward S. , Löffler Frank E. 
Published: September 2017

ABSTRACT

Dehalobacterium formicoaceticum
utilizes dichloromethane as the sole energy source in defined anoxic bicarbonate-buffered mineral salt medium. The products are formate, acetate, inorganic chloride, and biomass. The bacterium’s genome was sequenced using PacBio, assembled, and annotated. The complete genome consists of one 3.77-Mb circular chromosome harboring 3,935 predicted protein-encoding genes.
Complete Genome Sequence of Ralstonia solanacearum FJAT-91, a High-Virulence Pathogen of Tomato Wilt
Authors: Chen Deju , Liu Bo , Zhu Yujing , Zhang Haifeng , Chen Zheng , Zheng Xuefang , Xiao Rongfeng , Chen Yanping 
Published: September 2017

ABSTRACT

Ralstonia solanacearum
FJAT-91, which displays higher virulence toward plants belonging to the family
Solanaceae
, was isolated from a wilted tomato plant vessel in Fujian province, southeast China. Here, we report the complete genome sequence of
R. solanacearum
FJAT-91 using long-read single-molecule PacBio sequencing technology. The genome comprises a 3,873,214-bp circular chromosome and a 2,000,873-bp circular megaplasmid with an overall G+C content of 66.85%.
Complete Genome Sequence of Spiroplasma corruscae EC-1
T
(DSM 19793), a Bacterium Isolated from a Lampyrid Beetle (Ellychnia corrusca)
Authors: Tsai Yi-Ming , Lo Wen-Sui , Kuo Chih-Horng 
Published: September 2017

ABSTRACT

Spiroplasma corruscae
EC-1
T
(DSM 19793) was isolated from the gut of a lampryid beetle (
Ellychnia corrusca
) collected in Beltsville, MD, USA, in 1983. Here, we report the complete genome sequence of this bacterium to facilitate the investigation of its biology and the comparative genomics among
Spiroplasma
species.
Draft Genome Sequence of Klebsiella pneumoniae OK8, a Multidrug-Resistant Mouse and Human Pathogen
Authors: Nagamalleswari Easa , Nagaraja Valakunja 
Published: September 2017

ABSTRACT

We report here the draft genome sequence of
Klebsiella pneumoniae
OK8, a multidrug-resistant strain which was isolated in 1976 from a human and is known to be a mouse pathogen.
Validity of studies suggesting postsurgical chemotherapy for resectable gastric cancer: critical appraisal of randomised trials
Authors: Manzini Giulia , Henne-Bruns Doris , Kremer Michael 
Published: September 2017

Background and aimIn 2013, Diaz-Nietoet alpublished a Cochrane review to summarise the impact of postsurgical chemotherapy versus surgery alone on survival for resectable gastric cancer. The authors concluded that postsurgical chemotherapy showed an improvement in overall survival. The aim of this article was to assess the validity of four studies included in the Cochrane review and to investigate the impact of an exclusion of these four studies on the result of the meta-analysis.MethodsOverall survival was selected as endpoint of interest. Among the 34 included papers which analysed this endpoint, we identified the four publications which have the highest weights to influence the final result. The validity of these papers was analysed using the CONSORT (Consolidated Standards of Reporting Trials) checklist for randomised controlled trials. We performed a new meta-analysis without the four studies in order to assess their impact on the general result of the original meta-analysis.ResultsThe analysed four studies revealed several inconsistencies: inappropriate answers were found in up to 77% of the items of the CONSORT checklist. Unclear or inadequate randomisation, missing blinded set-up, conflict of interest and lacking intention-to-treat analysis were the most common findings. When performing a meta-analysis excluding the four criticised studies, postsurgical chemotherapy still showed a significant improvement in overall survival. Even when excluding all single studies with a statistically significant outcome by themselves and performing a meta-analysis on the remaining 26 studies, the result remains statistically significant.ConclusionThe four most powerful publications in the Cochrane review show substantial deficits. We suggest a more critical appraisal regarding the validity of single studies. However, after the exclusion of these four studies, the result of the meta-analysis did not change.
Effectiveness of a multifactorial intervention based on an application for smartphones, heart-healthy walks and a nutritional workshop in patients with type 2 diabetes mellitus in primary care (EMID): study protocol for a randomised controlled trial
Authors: Alonso-Domínguez Rosario , Gómez-Marcos Manuel A , Patino-Alonso Maria C , Sánchez-Aguadero Natalia , Agudo-Conde Cristina , Castaño-Sánchez Carmen , García-Ortiz Luis , Recio-Rodríguez José I 
Published: September 2017

IntroductionNew information and communication technologies (ICTs) may promote lifestyle changes, but no adequate evidence is available on their combined effect of ICTs with multifactorial interventions aimed at improving diet and increasing physical activity in patients with type 2 diabetes mellitus (DM2). The primary objective of this study is to assess the effect of a multifactorial intervention to increase physical activity and adherence to Mediterranean diet in DM2.Methods and analysisStudy scope and population:The study will be conducted at ‘La Alamedilla’ primary care research unit in Salamanca (Spain). 200 patients with DM2 of both sexes, aged 25–70 years and who meet the inclusion criteria and sign the informed consent will be recruited. Each participant will attend the clinic at baseline and 3 and 12 months after intervention.InterventionBoth groups will be given short advice on diet and physical activity. The intervention group will also take five heart-healthy walks and attend a group session on diet education and will be trained on use of an application for smartphone (EVIDENT II) for 3 months.Variables and measurement instrumentsThe main study endpoints will be changes in physical activity, as assessed by a pedometer and the International Physical Activity Questionnaire, and adherence to the Mediterranean diet, as evaluated by an adherence questionnaire and the Diet Quality Index. Anthropometric parameters and laboratory values, lifestyles and quality of life will also be assessed.Ethics and disseminationIt was approved by the Clinical Research Ethics Committee of Salamanca on 28/11/2016.Trial registrationNCT02991079; Pre-results.
Frequency of low-value care in Alberta, Canada: a retrospective cohort study
Authors: McAlister Finlay A , Lin Meng , Bakal Jeff , Dean Stafford 
Published: September 2017

ObjectiveTo determine how frequently 10 low-value services highlighted by Choosing Wisely are done and what factors influence their provision.MethodsThis is a retrospective cohort study using routinely collected health data from five linked data sets from 2012 to 2015 in the Canadian province of Alberta to determine the frequency with which 10 low-value services were provided.ResultsBetween 2012 and 2015, 162 143 people (4% of all 3 814 536 adult Albertans and 5% of the 3  423 135 who saw a physician at least once in that time frame) received at least one of the 10 low-value services, including 29.8% of Albertans older than 75 years (57 811 of 194 068). The proportion of adults receiving low-value services ranged from carotid artery imaging in 0.1% of asymptomatic adults without cerebrovascular disease, to prostate-specific antigen (PSA) testing in 55.5% of men 75 years or older without a history of prostate cancer. Although age, Charlson scores and frequency of primary care visits were associated with low-value service provision, the directions of the association differed across services; however, higher socioeconomic status, increased frequency of specialist contact and higher ratio of specialists to primary care physicians in the patient’s region were associated with an increased risk of receiving all of the low-value services we examined. The low-value services which resulted in the greatest costs to the healthcare system were cervical cancer screening in women older than 65 without history of cervical dysplasia or genital cancer, PSA testing in men older than 75 without history of prostate cancer and preoperative stress testing/cardiac imaging before non-cardiac surgery.ConclusionsEven within a universal coverage healthcare system, the proportion of patients receiving low-value services varied widely (from <0.1% to 56%). Increased use was associated with higher socioeconomic status, increased frequency of specialist contact and higher ratio of specialists to primary care physicians.
Associations between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis, and betweenMIFgene polymorphisms and disease susceptibility: a meta-analysis
Authors: Bae Sang-Cheol , Lee Young Ho 
Published: September 2017

AbstractAimTo systematically review evidence regarding the relationship between circulating macrophage migration inhibitory factor (MIF) levels and rheumatoid arthritis (RA), and the association between MIF gene polymorphisms and RA susceptibility.DesignWe performed a meta-analysis on data of serum/plasma MIF levels in patients with RA and in controls, and on associations between the MIF−173 C/G and −794CATT5-8 polymorphisms and RA susceptibility.PatientsTwelve studies, comprising a total of 362 RA cases and 531 controls evaluated for MIF levels, and 2367 RA cases and 2395 controls evaluated for MIF polymorphisms, were included.ResultsMIF levels were significantly higher in the RA group than in the control group (standardised mean difference (95% CI) 0.923 (0.766 to 1.080), p&lt;0.001). Stratification by ethnicity revealed significantly higher MIF levels in the RA group in Caucasian, Asian and Latin American populations. MIF levels were significantly higher in patients with RA, regardless of adjustment, sample size or data type evaluated. RA was identified to be significantly associated with the MIF−173 C allele (OR (95% CI) 1.271 (1.141 to 1.416), p&lt;0.001), as well as with the −794CATT7 allele (OR (95% CI) 1.229 (1.084 to 1.415), p=0.002) and the −794CATT7-MIF-173C haplotype RA (OR (95% CI) 1.433 (1.138 to 1.805), p=0.002).ConclusionsOur meta-analyses revealed significantly higher circulating MIF levels in patients with RA, and found evidence of associations between the MIF−173 C/G and −794CATT5-8 polymorphisms and RA susceptibility.
Towards memory-efficient processing-in-memory architecture for convolutional neural networks
Authors: Wang Yi , Zhang Mingxu , Yang Jing 
Published: September 2017

Convolutional neural networks (CNNs) are widely adopted in artificial intelligent systems. In contrast to conventional computing centric applications, the computational and memory resources of CNN applications are mixed together in the network weights. This incurs a significant amount of data movement, especially for highdimensional convolutions. Although recent embedded 3D-stacked Processing-in-Memory (PIM) architecture alleviates this memory bottleneck to provide fast near-data processing, memory is still a limiting factor of the entire system. An unsolved key challenge is how to efficiently allocate convolutions to 3D-stacked PIM to combine the advantages of both neural and computational processing.
This paper presents Memolution, a compiler-based memory efficient data allocation strategy for convolutional neural networks on PIM architecture. Memolution offers thread-level parallelism that can fully exploit the computational power of PIM architecture. The objective is to capture the characteristics of neural network applications and present a hardware-independent design to transparently allocate CNN applications onto the underlining hardware resources provided by PIM. We demonstrate the viability of the proposed technique using a variety of realistic convolutional neural network applications. Our extensive evaluations show that, Memolution significantly improves performance and the cache utilization compared to the baseline scheme.