bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of statin use and stress-induced hyperglycemia in patients with acute ST-elevation myocardial infarction
Authors: Yan Chen , Qin Ma , Juan Yang S , Tao Li Y , dong Gao M , Zechun Zeng , Chun Yang X , Liang Cong H , Yin Liu , Kang Meng 
Published: April 2016

Background Only a few information is available on the risk of stress hyperglycemia following acute myocardial infarction after statin use. We investigate the association of stress-induced hyperglycemia following statin use in patients with acute myocardial infarction. Methods An observational analysis of 476 consecutive patients who suffered acute myocardial infarction was carried out. All selected patients were divided into diabetes mellitus and non-diabetes based on the presence or absence of diabetes. The cardiac incidence of in-hospital and stress-induced hyperglycemia was recorded. Results Among patients with stress hyperglycemia in non-diabetes mellitus subgroups, the average fasting plasma glucose values in statin users were higher than in non-statin users (P < 0.05). But in diabetes mellitus subgroups, the average fasting plasma glucose did not have a significant difference between statin users and non-statin users (P > 0.05). In non-diabetes mellitus patients, the incidence of stress hyperglycemia with statin therapy was significantly higher than with non-statin therapy (P = 0.003). But in diabetes mellitus patients group, there is no significant difference in incidence of stress hyperglycemia between patients with statin therapy and patients without statin therapy (P = 0.902).The incidence of heart failure and in-hospital mortality of acute myocardial infarction in patients with stress-induced hyperglycemia was significantly higher than in non-hyperglycemia patients (P < 0.05). Conclusion Statins are related to higher stress hyperglycemia and cardiac incidences after acute myocardial infarction.
A primal-dual fixed point algorithm for minimization of the sum of three convex separable functions
Authors: Chen Peijun , Huang Jianguo , Zhang Xiaoqun 
Published: April 2016

AbstractMany problems arising in image processing and signal recovery with multi-regularization and constraints can be formulated as minimization of a sum of three convex separable functions. Typically, the objective function involves a smooth function with Lipschitz continuous gradient, a linear composite nonsmooth function, and a nonsmooth function. In this paper, we propose a primal-dual fixed point (PDFP) scheme to solve the above class of problems. The proposed algorithm for three-block problems is a symmetric and fully splitting scheme, only involving an explicit gradient, a linear transform, and the proximity operators which may have a closed-form solution. We study the convergence of the proposed algorithm and illustrate its efficiency through examples on fused LASSO and image restoration with non-negative constraint and sparse regularization.
In vivo Wnt pathway inhibition of human squamous cell carcinoma growth and metastasis in the chick chorioallantoic model
Authors: Rudy Shannon F. , Brenner J. Chad , Harris Jennifer L. , Liu Jun , Che Jianwei , Scott Megan V. , Owen John Henry , Komarck Christine M. , Graham Martin P. , Bellile Emily L. , Bradford Carol R. , Prince Mark EP , Carey Thomas E. 
Published: April 2016

Background Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with poor overall survival. New therapeutic strategies that target specific molecular lesions driving advanced disease are needed. Herein we demonstrate the utility of the chicken chorioallantoic membrane (CAM) assay for in vivo human HNSCC tumor growth and metastasis and the tumor suppressive effects of a new chemotherapeutic agent. Methods We tested anti-metastatic effects of a WNT pathway inhibitor, WNT974 (also known as LGK974), which targets porcupine (PORCN) the palmityl-transferase that is essential for secretion of Wnt proteins. CAM assays were performed with 8 HNSCC cell lines: UM-SCC-1, UM-SCC-10A, UM-SCC-10B, UM-SCC-11A, UM-SCC-14A UM-SCC-17A, UM-SCC-17B, UM-SCC-25, and UM-SCC-34. Results UM-SCC-1 (University of Michigan Squamous Cell Carcinoma cell line) CAM xenografts contain CD44+ and ALDH+ cancer stem cell (CSC) proportions similar to UM-SCC-1 mouse xenografts supporting the applicability of the CAM assay for study of CSCs. Inhibition of WNT signaling by the PORCN inhibitor WNT974 reduced metastatic spread of UM-SCC cells, especially in UM-SCCs with Notch1 deficiency. Conclusions Our data demonstrate decreased tumor growth and metastases in tumors from cell lines that showed in vitro responses to WNT974, providing evidence that this agent may have a role in future HNSCC therapy.
Response to Cetuximab With or Without Irinotecan in Patients With Refractory Metastatic Colorectal Cancer Harboring the KRAS G13D Mutation: Australasian Gastro-Intestinal Trials Group ICECREAM Study
Authors: Segelov Eva , Thavaneswaran Subotheni , Waring Paul M. , Desai Jayesh , Robledo Kristy P. , Gebski Val J. , Elez Elena , Nott Louise M. , Karapetis Christos S. , Lunke Sebastian , Chantrill Lorraine A. , Pavlakis Nick , Khasraw Mustafa , Underhill Craig , Ciardiello Fortunato , Jefford Michael , Wasan Harpreet , Haydon Andrew , Price Timothy J. , van Hazel Guy , Wilson Kate , Simes John , Shapiro Jeremy D. 
Published: April 2016

Purpose RAS mutations predict lack of response to epidermal growth factor receptor monoclonal antibody therapy in patients with metastatic colorectal cancer (mCRC), but preclinical studies and retrospective clinical data suggest that patients with tumors harboring the exon 2 KRAS G13D mutation may benefit from cetuximab. We aimed to assess cetuximab monotherapy and cetuximab plus irinotecan in patients with molecularly selected (G13D mutation) chemotherapy-refractory mCRC in a randomized phase II trial of this rare molecular subtype. Patients and Methods Patients with chemotherapy-refractory KRAS G13D mutation–positive mCRC who had progressed within 6 months of irinotecan therapy were randomly assigned to cetuximab 400 mg/m2 loading dose and then 250 mg/m2 once per week with or without irinotecan 180 mg/m2 once every 2 weeks. The primary end point was 6-month progression-free survival; secondary end points were response rate, overall survival, quality of life, and toxicity. Results Fifty-one of 53 patients recruited over 2 years were eligible. The 6-month progression-free survival rate was 10% (95% CI, 2% to 26%) for cetuximab versus 23% (95% CI, 9% to 40%) for cetuximab plus irinotecan with a hazard ratio of 0.74 (95% CI, 0.42 to 1.32). Response and stable disease rates were 0% and 58% for monotherapy versus 9% and 70% for combination treatment, respectively. Overall survival and quality of life were similar; toxicities were higher with combination therapy. Conclusion In patients with G13D-mutated chemotherapy-refractory mCRC, there was no statistically significant improvement in disease control at 6 months with either cetuximab monotherapy or cetuximab plus irinotecan. No responses were seen with single-agent cetuximab. The responses observed with the combination of cetuximab and irinotecan may reflect true drug synergy or persistent irinotecan sensitivity. The ICECREAM (Irinotecan Cetuximab Evaluation and Cetuximab Response Evaluation Among Patients with a G13D Mutation) study demonstrates the need to prospectively evaluate hypotheses that were previously supported by retrospective analyses and exemplifies the value of international collaboration in trials of rare molecular subtypes.
Estimated probability of Corporate Bankruptcy by the Example of PJSC «Rostelecom»
Authors: Солтаханов  , Soltakhanov A. 
Published: April 2016

Th is article gives a brief overview of the economic situation in Russia in 2014-2015, an analysis was carried
out to determine the fi nancial situation and the probability of bankruptcy of PJSC «Rostelecom» using the most famous
foreign and domestic multifactor models which predict insolvency of the organization.
Biomechanical Rupture Risk Assessment
Authors: Gasser T. Christian 
Published: April 2016

AbstractAbdominal aortic aneurysm (AAA) rupture is a local event in the aneurysm wall that naturally demands tools to assess the risk for local wall rupture. Consequently, global parameters like the maximum diameter and its expansion over time can only give very rough risk indications; therefore, they frequently fail to predict individual risk for AAA rupture. In contrast, the Biomechanical Rupture Risk Assessment (BRRA) method investigates the wall’s risk for local rupture by quantitatively integrating many known AAA rupture risk factors like female sex, large relative expansion, intraluminal thrombus-related wall weakening, and high blood pressure. The BRRA method is almost 20 years old and has progressed considerably in recent years, it can now potentially enrich the diameter indication for AAA repair. The present paper reviews the current state of the BRRA method by summarizing its key underlying concepts (i.e., geometry modeling, biomechanical simulation, and result interpretation). Specifically, the validity of the underlying model assumptions is critically disused in relation to the intended simulation objective (i.e., a clinical AAA rupture risk assessment). Next, reported clinical BRRA validation studies are summarized, and their clinical relevance is reviewed. The BRRA method is a generic, biomechanics-based approach that provides several interfaces to incorporate information from different research disciplines. As an example, the final section of this review suggests integrating growth aspects to (potentially) further improve BRRA sensitivity and specificity. Despite the fact that no prospective validation studies are reported, a significant and still growing body of validation evidence suggests integrating the BRRA method into the clinical decision-making process (i.e., enriching diameter-based decision-making in AAA patient treatment).
Hot Pressing of Wood-Based Composites: A Review
Authors: Wei Peixing , Rao Xin , Yang Jing , Guo Yeyingzi , Chen Huimin , Zhang Yue , Chen Shihui , Deng Xi , Wang Zheng 
Published: April 2016

Abstract
The hot-pressing process is a vital step in the manufacture of wood-based composites and directly affects the properties and quality of the final products. During hot pressing, the heat and mass transfer process interact with each other, coupling with the mechanical deformation process of wood-based composites under the high-temperature interaction. In addition, the curing of resin, although governed by the laws of chemical reactions, can result in the release or absorption of heat and water, which may, in turn, affect the heat and mass transfer process. Realizing its complex and coupling nature, many scientists have conducted long-term, multisided and multilevel studies to better understand hot pressing. This work reviews the development of wood composite hot pressing, including the heating methods of hot pressing, the mechanism of heat and mass transfer, the hot-pressing models, and the experimental testing of the internal environment. The shortage of current studies and potential directions for future research are also discussed.
Von Hippel-Lindau disease: the clinical manifestations and genetic analysis results of two cases from a single family
Authors: Kinyas S , Ozal SA , Guclu H , Gurlu V , Esgin H , Gurkan H 
Published: April 2016

Abstract
von Hippel-Lindau (VHL) disease is an autosomal dominant inherited multi systemic cancer syndrome that is classically associated with neoplasms in multiple organs, and caused by mutations in the VHL gene on chromosome 3p25-p26. Retinal hemangioblastoma (RH) is the most frequent and the earliest clinical sign of the disease, which is seen in 40.0-60.0% of patients. In recent years, studies of patients with VHL tried to put forward the relationship between genotype and phenotype. In this study, two VHL cases in the same family with clinical findings and genetic analysis results are presented. As a consequence of the genetic studies, a heterozygous missense mutation c.202 T>C, p.S68P (Ser68Pro) in exon 1 of the VHL gene that is mapped to chromosome 3p25.3, was found in the patients’ DNA sample. The germline mutation of [c.202T>C, p.S68P (Ser68Pro)] that was detected in both cases, has been reported in only two cases in the literature. However, in these reported cases, any systemic involvement except RH, were not reported. Although our cases had the same mutation, we detected renal involve-ment in both cases, and also central nervous system (CNS) involvement in one case, in addition to RH.
Modelling of Piezothermoelastic Beam with Fractional Order Derivative
Authors: Kumar Rajneesh , Sharma Poonam 
Published: April 2016

AbstractThis paper deals with the study of transverse vibrations in piezothermoelastic beam resonators with fractional order derivative. The fractional order theory of thermoelasticity developed by Sherief et al. [1] has been used to study the problem. The expressions for frequency shift and damping factor are derived for a thermo micro-electromechanical (MEM) and thermo nano-electromechanical (NEM) beam resonators clamped on one side and free on another. The effect of fractional order derivative on the derived expressions is observed analytically and shown graphically in the case of Lead Zirconate Titanate (PZT)-5A material. For α = 1, our results agree with those that are obtained by Grover and Sharma [20] and other particular cases of interest are also discussed.
Effects of exposure to three environmental chemicals on the selected biochemical parameters of the blood plasma of rainbow trout, Oncorhynchus mykiss (Walbaum)
Authors: Řehulka Jiří , Minařík Bohumil , Machala Miroslav 
Published: April 2016

Abstract
Rainbow trout Oncorhynchus mykiss at a weight of 115 ± 24 g (mean ± SD) were experimentally injected with di(2-ethylhexyl)phthalate (DEHP), 2,3,7,8-tetrachlorodibenzo-p-dioxine (TCDD) and gamma isomer of hexachlorocyclohexane (γ-HCH ) to evaluate nitrogen metabolism (total protein [TP], blood urea nitrogen, uric acid [UA], creatinine), carbohydrate metabolism (glucose), mineral metabolism (inorganic phosphate[P], total calcium [Cat]), and catalytic activity of enzymes (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [ALP], lactate dehydrogenase [LD]). After 21 days, the tested xenobiotics, administered by the intraperitoneally route, caused the following effect: in comparison with negative controls, fish injected with DEHP at concentrations of 200 or 50 mg kg-1 of body weight were found to have a higher level of P and lower level of Cat and decreased catalytic concentrations of ALT, AST, ALP and LD in the plasma of the peripheral blood. A higher level of TP and P and a decreased catalytic concentration of ALT were found when TCDD was administered at a dose of 2 μg kg-1. A decrease in the catalytic concentrations of ALT and ALP occurred in fish injected with γ-HCH in a dose of 50 mg kg-1. UA and P levels were decreased in fish injected with γ-HCH in a dose of 5 mg kg-1. DEHP and TCDD caused neutrophilic leucocytosis with a marked left shift. Both concentrations of γ-HCH led to an increase in polychromatophilic erythrocytes. The frequency of micronuclei varied in all experimental groups, including the controls, ranging between 0.8 and 2.1 ‰. Histological examination in fish injected with DEHP at a concentration of 200 mg kg-1 revealed eosinophilic droplets in the epithelium of renal tubules and histological examination in fish injected with γ-HCH at a higher concentration revealed an increased activation of sinusoidal cells in the liver, a fibrous thickening of bile duct walls, bile duct hyperplasia and a periductal inflammatory.
New records of the flat-footed flies (Diptera: Platypezidae) from the Czech Republic and Bohemia
Authors: Tkoč Michal 
Published: April 2016

Abstract
Flat-footed fly (Diptera: Platypezidae) Agathomyia cinerea (Zetterstedt, 1852) is recorded from the Czech Republic for the first time, based on specimens found in the Bukovec Nature Reserve near Jizerka (Kořenov) in the Jizerské hory Mts and Svatý Petr in the Krkonoše Mts. The distribution, seasonal occurrence and habitat preference of this species in Europe are commented. Additionally, two other flat-footed flies, Polyporivora picta (Meigen, 1830) and Seri obscuripennis (Oldenberg, 1916) are recorded for the first time from the territory of Bohemia.
Branding Raw Material to Improve Human Rights: Intel’s Ban on Conflict Minerals
Authors: Osburg Thomas 
Published: April 2016

Abstract
Many companies seek to take over more responsibility for their supply chain and their raw materials. Intel was one of the first companies investigating the origin of conflict minerals like tin, tantalum, gold or tungsten, which are used in many electronic products. Their path to ultimately offering conflict-free microprocessors took more than five years of consistent preparation and intensive reengineering of the business process. They identified smelters as a bottleneck in the supply chain and started cooperating closely with them to trace their minerals’ supply. By developing a bag-and-tag system the company is now able to ensure that their minerals are not sourced from illegal mines, which often finance illegal warlords, for example, in the eastern Democratic Republic of Congo. The cooperation with the smelters brings about higher demand and in consequence higher prices for the legally sourced minerals. Many small miners and their families in the region directly benefit from the higher earnings.
Optimization of Storage Conditions of Malta (Citrus sinensis) Using Response Surface Methodology
Authors: Richa Rishi , Pandey J.P. , Shahi N.C. , Kautkar S.S. 
Published: April 2016

Abstract
Response surface methodology was used to determine the optimum storage conditions of malta fruits that give minimum weight loss and maximum total soluble solid (TSS) retained value. Scavenger (3–5 g), polythene thickness (75–125 gauge) and fungicide concentration (75–200 ppm) were the factors investigated. Experiments were designed according to Box–Behnken design with these three factors, including central points. For each response, a second-order polynomial model was developed using multiple linear regression analysis. Applying desirability function method, optimum storage conditions were found to be 5 g scavenger, 125 gauge polythene thickness and 200 ppm fungicide concentration.
Poeticizing the Psalter in an African Language
Authors: Wendland Ernst R. 
Published: April 2016

Abstract
This study illustrates the application of a literary methodology to the analysis and translation of
biblical poetry. The aim is twofold: first and foundational, to reveal salient aspects of the beauty and power
of Psalm 13 in the original Hebrew; and second, to experiment with different methods of communicating
the original meaning of the psalmist’s passionate prayer with respect to lyric form, content, and function
in Chichewa, a major Bantu language. After a thorough examination of the principal structural and
stylistic features of the biblical text, a typical lament psalm, several published and unpublished Chewa
translations are critically discussed. The ultimate purpose is, as the title of this paper suggests, to produce
an acceptable, functionally equivalent, poetic version of the Hebrew text in the vernacular. In conclusion,
the main principles illustrated in this study are summarized in an effort to encourage more dynamic,
idiomatic, indeed melodic translations of the Scriptures in local languages, where circumstances allow.
“How long” must so many reader-hearers suffer under the burden of a less than communicative version of
the Psalter in their mother tongue?
Theology Without Walls: Sic et Non
Authors: Feldmeier Peter 
Published: April 2016

Abstract
The emerging project, Theology Without Walls, is fascinating and potentially highly fruitful,
particularly given the recognized imperative for doing theology in light of a religiously plural world. But it
is also a project with daunting methodological and philosophical problems. In the first part of the paper,
the author describes why he is attracted to the project and how it might bear theological insight. He also
frames the project along the lines of multiple religious belonging, comparative theology, and the current
cultural zeitgeist. In the second part of the paper, he challenges how such a project would actually work,
given various religions’ diverse and competing metaphysical claims which undergird their theological
principles. Finally, he questions whether such a project would undermine the very purpose of theology for
the kind of public most inclined to being influenced by it. His title’s Sic et Non (Yes and No) refers to both
his commending Theology Without Walls and challenging its viability. He concludes that the collective
weight leads him to challenge the project, at least until it provides a method that satisfactorily addresses
his fundamental concerns.
A ‘No’ at the Core of Life
Authors: Weidenbaum Jonathan 
Published: April 2016

Abstract
The purpose of this essay is to unpack the relevance of William James for the project of a
transreligious theology. While the resources of reason and spiritual experience have long been employed to
arbitrate both within and between different spiritual traditions, I argue that James offers a third principle:
the encouragement of the morally active life, along with a corresponding depiction of the universe in which
our efforts may contribute to the nature of things.
The Breadth of the Riches
Authors: Sydnor Jon Paul 
Published: April 2016

Abstract
Is transreligious theology possible? Yes, but only as a very specific practice. If we accept the
neologism „transreligious“ then we must understand it in contrast with the more traditional terms
„interreligious“ and „comparative“. Interpreted this way, „transreligious theology“ describes religious
discourse about ultimate reality between those with no particular religious identity. Their conversation is
panreligious, treating all theological resources equally, without preference for any tradition over any other
tradition. This conversation will be quite different from interreligious dialogue or comparative theology, in
which participants claim a religious identity while remaining open to the insights of other traditions. Hence,
„transreligious theology“ is a descriptive term rather than a prescriptive method. It is already practiced by
the non-religiously affiliated who hold an interest in the spirituality of all religions. Even though it may
be helpful to some, it is not a necessary practice, since effective theological development can still occur
between those with specific religious identities, and by those who only study their own religious traditions.
Clinical and Pastoral Implications of the
Ministry of Martin Luther and the Protestant
Reformation
Authors: Judd Daniel K. 
Published: April 2016

Abstract
While acknowledging that many theological beliefs and religious practices facilitate mental
health and emotional stability, the major purpose of this paper is to identify and demonstrate that some
of these same beliefs and practices can also contribute to mental instability if understood incorrectly
and practiced unwisely. The unique content of this paper is a pastoral, clinical, and historical narrative
concerning the relationships of religious belief and practice with the mental health of 16th century priest,
pastor, professor, and Protestant reformer Martin Luther. Specifically, this paper discusses Luther’s personal
experiences with mental and emotional instability, including depression and scrupulosity, and explores
ways that discovering and embracing the principle of grace assisted him in dealing with his own mental
and emotional crises. This paper also treats ways that both psychological and theological understanding of
the relationship between the doctrinal principles of grace and human volition can assist both health care
professionals and clergy to provide effective care to those they serve.