bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methionine tumor starvation by erythrocyte‐encapsulated methionine gamma‐lyase activity controlled with per os vitamin B6
Authors: Gay Fabien , Aguera Karine , Sénéchal Karine , Tainturier Angie , Berlier Willy , Maucort‐Boulch Delphine , Honnorat Jérôme , Horand Françoise , Godfrin Yann , Bourgeaux Vanessa 
Published: May 2017

AbstractErymet is a new therapy resulting from the encapsulation of a methionine gamma‐lyase (MGL; EC number 4.4.1.11) in red blood cells (RBC). The aim of this study was to evaluate erymet potential efficacy in methionine (Met)‐dependent cancers. We produced a highly purified MGL using a cGMP process, determined the pharmacokinetics/pharmacodynamics (PK/PD) properties of erymet in mice, and assessed its efficacy on tumor growth prevention. Cytotoxicity of purified MGL was tested in six cancer cell lines. CD1 mice were injected with single erymet product supplemented or not with vitamin B6 vitamer pyridoxine (PN; a precursor of PLP cofactor). NMRI nude mice were xenografted in the flank with U‐87 MG‐luc2 glioblastoma cells for tumor growth study following five intravenous (IV) injections of erymet with daily PN oral administration. Endpoints included efficacy and event‐free survival (EFS). Finally, a repeated dose toxicity study of erymet combined with PN cofactor was conducted in CD1 mice. Recombinant MGL was cytotoxic on 4/6 cell lines tested. MGL half‐life was increased from <24 h to 9–12 days when encapsulated in RBC. Conversion of PN into PLP by RBC was demonstrated. Combined erymet + PN treatment led to a sustained Met depletion in plasma for several days with a 85% reduction of tumor volume after 45 days following cells implantation, and a significant EFS prolongation for treated mice. Repeated injections in mice exhibited a very good tolerability with only minor impact on clinical state (piloerection, lean aspect) and a slight decrease in hemoglobin and triglyceride concentrations. This study demonstrated that encapsulation of methioninase inside erythrocyte greatly enhanced pharmacokinetics properties of the enzyme and is efficacy against tumor growth. The perspective on these results is the clinical evaluation of the erymet product in patients with Met starvation‐sensitive tumors.
Analysis of physical characteristics of Tumor Treating Fields for human glioblastoma
Authors: Lok Edwin , San Pyay , Hua Van , Phung Melissa , Wong Eric T. 
Published: May 2017

AbstractTumor Treating Fields (TTFields) therapy is an approved treatment that has known clinical efficacy against recurrent and newly diagnosed glioblastoma. However, the distribution of the electric fields and the corresponding pattern of energy deposition in the brain are poorly understood. To evaluate the physical parameters that may influence TTFields, postacquisition MP‐RAGE, T1 and T2 MRI sequences from a responder with a right parietal glioblastoma were anatomically segmented and then solved using finite‐element method to determine the distribution of the electric fields and rate of energy deposition at the gross tumor volume (GTV) and other intracranial structures. Electric field–volume histograms (EVH) and specific absorption rate–volume histograms (SARVH) were constructed to numerically evaluate the relative and/or absolute magnitude volumetric differences between models. The electric field parameters EAUC, VE150, E95%, E50%, and E20%, as well as the SAR parameters SARAUC, VSAR7.5, SAR95%, SAR50%, and SAR20%, facilitated comparisons between models derived from various conditions. Specifically, TTFields at the GTV were influenced by the dielectric characteristics of the adjacent tissues as well as the GTV itself, particularly the presence or absence of a necrotic core. The thickness of the cerebrospinal fluid on the convexity of the brain and the geometry of the tumor were also relevant factors. Finally, the position of the arrays also influenced the electric field distribution and rate of energy deposition in the GTV. Using EVH and SARVH, a personalized approach for TTFields treatment can be developed when various patient‐related and tumor‐related factors are incorporated into the planning procedure.
Detail‐preserving SPH fluid control with deformation constraints
Authors: Feng Gang , Liu Shiguang 
Published: May 2017

AbstractIt is challenging to drive particle‐based smoothed‐particle hydrodynamics fluid to match the target shape and the deforming fluid shape between different models smoothly, especially when the natural fluid motion must be preserved. To achieve the desired behavior, we first generate control particles by sampling the target shapes and then apply a deformation constraint to each control particle, with its neighboring fluid particles keeping details within its influence region. For the generation of control particles, we classify input models into source object and target object, then separately sample them by voxelization method, and generate source control particles and target control particles, respectively. Our deformation constraint includes two parts. In the first part, we deform the source control model to the target control model according to specific space point correspondence between source control particles and target control particles; then, fluid particles are attracted by control particles and complete deformation between different shapes. In the second part, to reduce the lacking of fluid details when fluid deforms, we introduce a new control energy transfer mechanism for control particles. This deformation constraint is solved under smoothed‐particle hydrodynamics‐based fluid simulation framework, which makes our simulation fast, robust, and well suitable for interactive applications. Various experiments demonstrated the effectiveness of our method.
Alternative prosthodontic‐based treatment of a patient with hypocalcified type Amelogenesis Imperfecta
Authors: Jivanescu Anca , Miglionico Antonio , Barua Souman , Hategan Simona Ioana 
Published: May 2017

Key Clinical MessageThe Amelogenesis Imperfecta is associated with malocclusion and usually requires an interdisciplinary treatment. Due to the patient's refusal of orthodontic treatment, prosthodontics‐based treatments alternative was considered and planned. The patient was treated with zirconia‐based fixed partial dentures, which resulted in improved occlusion, better oral health, and improved esthetic appearance.
Inhibition of the Aggregation and Toxicity of the Minimal Amyloidogenic Fragment of Tau by Its Pro‐Substituted Analogues
Authors: Chemerovski‐Glikman Marina , Frenkel‐Pinter Moran , Mdah Ragad , Abu‐Mokh Amjaad , Gazit Ehud , Segal Daniel 
Published: May 2017

AbstractInhibiting the toxic aggregation of amyloid‐β and the tau protein, the key pathological agents involved in Alzheimer's, is a leading approach in modulating disease progression. Using an aggregative tau‐derived model peptide, Ac‐PHF6‐NH2, the substitution of its amino acids with proline, a known efficient β‐breaker, is shown to reduce self‐assembly. This effect is attributed to the steric hindrance created by the proline substitution, which results in disruption of the β‐sheet formation process. Moreover, several of the proline‐substituted peptides inhibit the aggregation of Ac‐PHF6‐NH2 amyloidogenic peptide. Two of these modified inhibitors also disassemble pre‐formed Ac‐PHF6‐NH2 fibrils and one inhibits induced cytotoxicity of the fibrils. Taken together, these lead β‐breaker peptides may be developed into novel Alzheimer's disease therapeutics.
Estimation of a generalized linear mixed model for response‐adaptive designs in multi‐centre clinical trials
Authors: Selvaratnam Selvakkadunko , Oyet Alwell J. , Yi Yanqing , Gadag Veeresh 
Published: May 2017

AbstractResponse‐adaptive designs are important alternatives to equal allocation in clinical trials because equal treatment allocation has been found to have ethical issues. In this article we discuss the implementation of response‐adaptive designs in multi‐centre clinical trials. We develop a generalized linear mixed model (GLMM) for analyzing data obtained from multi‐centre clinical trials and use the maximum likelihood (ML) approach to estimate the model parameters. We apply influence function techniques to derive the asymptotic properties of our estimators. The advantage of using the influence function approach is that it leads to a closed form expression for the asymptotic covariance of the estimated parameters. To our knowledge such a closed form expression does not currently exist in the literature. The performance of the ML estimator under various response‐adaptive designs is examined through simulation studies. We use our simulation studies to compare the asymptotic covariance matrix, based on the influence function to that based on the inverse of the Hessian matrix obtained from the likelihood function of the observations. The techniques are applied to real data obtained from a multi‐centre clinical trial designed to compare two cream preparations (active drug/control) for treating an infection. The Canadian Journal of Statistics 45: 310–325; 2017 © 2017 Statistical Society of Canada
The Breast and Cervical Cancer Early Detection Program, Medicaid, and breast cancer outcomes among Ohio's underserved women
Authors: Koroukian Siran M. , Bakaki Paul M. , Htoo Phyo Than , Han Xiaozhen , Schluchter Mark , Owusu Cynthia , Cooper Gregory S. , Rose Johnie , Flocke Susan A. 
Published: May 2017

BACKGROUNDAs an organized screening program, the national Breast and Cervical Cancer Early Detection Program (BCCEDP) was launched in the early 1990s to improve breast cancer outcomes among underserved women. To analyze the impact of the BCCEDP on breast cancer outcomes in Ohio, this study compared cancer stages and mortality across BCCEDP participants, Medicaid beneficiaries, and “all others.”METHODSThis study linked data across the Ohio Cancer Incidence Surveillance System, Medicaid, the BCCEDP database, death certificates, and the US Census and identified 26,426 women aged 40 to 64 years who had been diagnosed with incident invasive breast cancer during the years 2002‐2008 (deaths through 2010). The study groups were as follows: BCCEDP participants (1‐time or repeat users), Medicaid beneficiaries (women enrolled in Medicaid before their cancer diagnosis [Medicaid/prediagnosis] or around the time of their cancer diagnosis [Medicaid/peridiagnosis]), and all others (women identified as neither BCCEDP participants nor Medicaid beneficiaries). The outcomes included advanced‐stage cancer at diagnosis and mortality. A multivariable logistic and survival analysis was conducted to examine the independent association between the BCCEDP and Medicaid status and the outcomes.RESULTSThe percentage of women presenting with advanced‐stage disease was highest among women in the Medicaid/peridiagnosis group (63.4%) and lowest among BCCEDP repeat users (38.6%). With adjustments for potential confounders and even in comparison with Medicaid/prediagnosis beneficiaries, those in the Medicaid/peridiagnosis group were twice as likely to be diagnosed with advanced‐stage disease (adjusted odds ratio, 2.20; 95% confidence interval, 1.83‐2.66).CONCLUSIONSMedicaid/peridiagnosis women are at particularly high risk to be diagnosed with advanced‐stage disease. Efforts to reduce breast cancer disparities must target this group of women before they present to Medicaid. Cancer 2017;123:3097–106. © 2017 American Cancer Society.
Impact of subsequent metastases on costs and medical resource use for prostate cancer patients initially diagnosed with localized disease
Authors: Li Tracy T. , Shore Neal D. , Mehra Maneesha , Todd Mary B. , Saadi Ryan , Leblay Gaetan , Aggarwal Jyoti , Griffiths Robert I. 
Published: May 2017

BACKGROUNDThe impact of subsequent metastases on costs and medical resource use (MRU) for prostate cancer (PC) patients initially diagnosed with localized disease was estimated.METHODSSurveillance, Epidemiology, and End Results data, linked to Medicare (1999‐2012), were used to identify 7482 patients diagnosed with subsequent metastases 12 months or more after the initial diagnosis of localized PC (cases), and they were matched to 25,709 localized PC patients without subsequent metastases (controls). Patients were followed for costs and MRU from 12 months before their index date (subsequent metastases or a matched date for controls) up to 12 months after it. Costs and MRU were stratified by the setting/type of care/service. Multivariate mixed effects regression analyses were used to construct and compare longitudinal trajectories of marginal predicted costs and predicted probabilities of MRU between cases and controls.RESULTSAmong the controls, predicted monthly costs remained relatively stable throughout the entire observation period (weighted mean per patient per month, $2746; range during 24 months, $2603‐2858). In contrast, among the cases, costs increased from $2622 (95% confidence interval [CI], $2525‐2719) 12 months before the diagnosis of subsequent metastases to $4767 (95% CI, $4623‐4910) 1 month before the diagnosis of subsequent metastases, peaked during the month of metastases at $13,291 (95% CI, $13,148‐13,435), and remained significantly higher than costs for the controls thereafter (eg, $4677 at + 12 months; 95% CI, $4549‐4805). Costs and MRU increased across a wide range of settings/types, including inpatient, outpatient, home health, and hospice settings.CONCLUSIONSIn PC patients initially diagnosed with localized disease, a diagnosis of subsequent metastases is associated with substantially increased costs and MRU. Cancer 2017;123:3591‐601. © 2017 American Cancer Society.
Multisite external validation of a risk prediction model for the diagnosis of blood stream infections in febrile pediatric oncology patients without severe neutropenia
Authors: Esbenshade Adam J. , Zhao Zhiguo , Aftandilian Catherine , Saab Raya , Wattier Rachel L. , Beauchemin Melissa , Miller Tamara P. , Wilkes Jennifer J. , Kelly Michael J. , Fernbach Alison , Jeng Michael , Schwartz Cindy L. , Dvorak Christopher C. , Shyr Yu , Moons Karl G.M. , Sulis Maria‐Luisa , Friedman Debra L. 
Published: May 2017

BACKGROUNDPediatric oncology patients are at an increased risk of invasive bacterial infection due to immunosuppression. The risk of such infection in the absence of severe neutropenia (absolute neutrophil count ≥ 500/μL) is not well established and a validated prediction model for blood stream infection (BSI) risk offers clinical usefulness.METHODSA 6‐site retrospective external validation was conducted using a previously published risk prediction model for BSI in febrile pediatric oncology patients without severe neutropenia: the Esbenshade/Vanderbilt (EsVan) model. A reduced model (EsVan2) excluding 2 less clinically reliable variables also was created using the initial EsVan model derivative cohort, and was validated using all 5 external validation cohorts. One data set was used only in sensitivity analyses due to missing some variables.RESULTSFrom the 5 primary data sets, there were a total of 1197 febrile episodes and 76 episodes of bacteremia. The overall C statistic for predicting bacteremia was 0.695, with a calibration slope of 0.50 for the original model and a calibration slope of 1.0 when recalibration was applied to the model. The model performed better in predicting high‐risk bacteremia (gram‐negative or Staphylococcus aureus infection) versus BSI alone, with a C statistic of 0.801 and a calibration slope of 0.65. The EsVan2 model outperformed the EsVan model across data sets with a C statistic of 0.733 for predicting BSI and a C statistic of 0.841 for high‐risk BSI.CONCLUSIONSThe results of this external validation demonstrated that the EsVan and EsVan2 models are able to predict BSI across multiple performance sites and, once validated and implemented prospectively, could assist in decision making in clinical practice. Cancer 2017;123:3781–3790. © 2017 American Cancer Society
The ascending projections of the nuclei of the descending trigeminal tract (nTTD) in the zebra finch (Taeniopygia guttata)
Authors: Faunes Macarena , Wild J. Martin 
Published: May 2017

AbstractIn our traditional view of the avian somatosensory system, input from the beak and head reaches the telencephalon via a disynaptic pathway, involving projections from the principal sensory nucleus (PrV) directly to nucleus basorostralis (previously called nucleus basalis), whereas input from the rest of the body follows a trisynatic pathway similar to that in mammals, involving projections from the dorsal column nuclei to the thalamus, and thence to somatosensory wulst. However, the role of the nuclei of the descending trigeminal tract (nTTD) in this scenario is unclear, partly because their ascending projections have been examined in only one species, the mallard duck. Here we examine the ascending projections of the nTTD in the zebra finch, using in vivo injections of biotinylated dextran amine and verification of projections by means of retrograde transport of the beta subunit of cholera toxin. The results show a high degree of interconnectivity within the nTTD, and that these nuclei project to PrV. We also find a projection from nTTD to the contralateral thalamic nucleus uvaeformis, a multi‐sensory nucleus connected to the song system. Furthermore, our finding of a projection from nTTD to the contralateral somatosensory thalamic nucleus dorsalis intermedius ventralis anterior (DIVA) is consistent with the well‐known projection in mammals from nTTD to the ventrobasal thalamus, suggesting that the ascending trigeminal pathways in birds and mammals are more similar than previously thought.
Personal autonomy in group‐based interventions
Authors: Koudenburg Namkje , Jetten Jolanda , Dingle Genevieve A. 
Published: May 2017

AbstractMarginalized individuals are often caught in a vicious cycle of economic or health problems, a lack of social connection and disempowerment. The present research examines interventions that provide opportunities for social inclusion to break this cycle. Specifically, in two longitudinal field studies, we examined the effect of social inclusion on self‐efficacy and hope in two vulnerable groups, namely, 68 residents in a drug and alcohol rehabilitation centre (Study 1) and 48 marginalized adults taking part in activities organized by a community organization (Study 2). Although somewhat counterintuitive, we hypothesized that social inclusion would affect self‐efficacy by fostering feelings of personal autonomy. The hypothesis was supported by results from both studies revealing an indirect effect from social inclusion via personal autonomy on self‐efficacy and hope. The findings are discussed in relation to how group inclusion may stimulate the development of personal autonomy in disadvantaged adults, an important factor in their recovery and mental health.
Verbs as linguistic markers of agency: The social side of grammar
Authors: Formanowicz Magdalena , Roessel Janin , Suitner Caterina , Maass Anne 
Published: May 2017

AbstractBasic grammatical categories may carry social meanings irrespective of their semantic content. In a set of four studies, we demonstrate that verbs—a basic linguistic category present and distinguishable in most languages—are related to the perception of agency, a fundamental dimension of social perception. In an archival analysis of actual language use in Polish and German, we found that targets stereotypically associated with high agency (men and young people) are presented in the immediate neighborhood of a verb more often than non‐agentic social targets (women and older people). Moreover, in three experiments using a pseudo‐word paradigm, verbs (but not adjectives and nouns) were consistently associated with agency (but not with communion). These results provide consistent evidence that verbs, as grammatical vehicles of action, are linguistic markers of agency. In demonstrating meta‐semantic effects of language, these studies corroborate the view of language as a social tool and an integral part of social perception.
Nostalgia in response to group‐based exclusion: The role of attachment‐related avoidance
Authors: Abakoumkin Georgios , Wildschut Tim , Sedikides Constantine , Bakarou Maria 
Published: May 2017

AbstractWe proposed that nostalgia, by virtue of its sociality, can be an indirect strategy to counteract relational deficiencies stemming from group‐based exclusion. We instructed Greek participants to recall an event in which they experienced exclusion on the basis of their nationality versus a control event. We anticipated that participants would react to group‐based exclusion with increased nostalgia. Specifically, because low attachment‐related avoidance facilitates proximity‐seeking in response to distress, we hypothesized that group‐based exclusion would increase nostalgia (a form of proximity‐seeking) more strongly when avoidance is low. Results supported this moderation hypothesis. In turn, increased nostalgia in response to group‐based exclusion predicted stronger ingroup identification. For low‐avoidants, then, group‐based exclusion fortified ingroup identification via increased nostalgia (moderated mediation).
Developing cognitions about race: White 5‐ to 10‐year‐olds' perceptions of hardship and pain
Authors: Dore Rebecca A. , Hoffman Kelly M. , Lillard Angeline S. , Trawalter Sophie 
Published: May 2017

AbstractWhite American adults assume that Blacks feel less pain than do Whites, but only if they believe that Blacks have faced greater economic hardship than Whites. The current study investigates when in development children first recognize racial group differences in economic hardship and examines whether perceptions of hardship inform children's racial bias in pain perception. Five‐ to 10‐year‐olds (N = 178) guessed which of two items (low versus high value) belonged to a Black and a White child and rated the amount of pain a Black and a White child would feel in 10 painful situations. By age 5, White American children attributed lower‐value possessions to Blacks than Whites, indicating a recognition of racial group differences in economic hardship. The results also replicated the emergence of a racial bias in pain perception between 5 and 10. However, unlike adults', children's perceptions of hardship do not account for racial bias in pain perception.
Thiophene–Arylamine Hole‐Transporting Materials in Perovskite Solar Cells: Substitution Position Effect
Authors: Liu Xuepeng , Kong Fantai , Ghadari Rahim , Jin Shengli , Chen Wangchao , Yu Ting , Hayat Tasawar , Alsaedi Ahmed , Guo Fuling , Tan Zhan'ao , Chen Jian , Dai Songyuan 
Published: May 2017

AbstractTwo facile thiophene–arylamine hole‐transporting materials, obtained by varying the substitution position of arylamine moieties on the thiophene π linker, are reported. The substitution position effect of two hole‐transporting materials on the performance of perovskite solar cells is further investigated theoretically and experimentally. The compound in which arylamine moieties are located on the 2,5‐substitution position of thiophene shows better conjunction than that with the 3,4‐substituent. When used as hole‐transporting materials in CH3NH3PbI3‐based solar cells, the 2,5‐substituent exhibits a power conversion efficiency (PCE) of 15.13 %, which is over 40 % higher than that of the 3,4‐substituent. Moreover, the PCE of 2,5‐substituent based device is comparable with that of 2,2′,7,7′‐tetrakis(N,N‐di‐p‐methoxyphenylamine)‐9,9′‐spirobifluorene (spiro‐OMeTAD).