bluuebunny/crossref_metadata_2025_split huggingface dataset:
A toolbox of immunoprecipitation-grade monoclonal antibodies against human transcription factors
Authors: Venkataraman Anand , Yang Kun , Irizarry Jose , Mackiewicz Mark , Mita Paolo , Kuang Zheng , Xue Lin , Ghosh Devlina , Liu Shuang , Ramos Pedro , Hu Shaohui , Bayron Diane , Keegan Sarah , Saul Richard , Colantonio Simona , Zhang Hongyan , Behn Florencia Pauli , Song Guang , Albino Edisa , Asencio Lillyann , Ramos Leonardo , Lugo Luvir , Morell Gloriner , Rivera Javier , Ruiz Kimberly , Almodovar Ruth , Nazario Luis , Murphy Keven , Vargas Ivan , Rivera-Pacheco Zully Ann , Rosa Christian , Vargas Moises , McDade Jessica , Clark Brian S. , Yoo Sooyeon , Khambadkone Seva G. , Melo Jimmy de , Stevanovic Milanka , Jiang Lizhi , Li Yana , Yap Wendy Y. , Jones Brittany , Tandon Atul , Campbell Elliot , Anderson Stephen , Myers Richard M. , Boeke Jef D. , Fenyo David , Whiteley Gordon , Bader Joel S. , Pino Ignacio , Eichinger Daniel J. , Zhu Heng , Blackshaw Seth 
Published: March 2017

AbstractA key component to overcoming the reproducibility crisis in biomedical research is the development of readily available, rigorously validated and renewable protein affinity reagents. As part of the NIH Protein Capture Reagents Program (PCRP), we have generated a collection of 1406 highly validated, immunoprecipitation (IP) and/or immunoblotting (IB) grade, mouse monoclonal antibodies (mAbs) to 736 human transcription factors. We used HuProt™ human protein microarrays to identify mAbs that recognize their cognate targets with exceptional specificity. Using an integrated production and validation pipeline, we validated these mAbs in multiple experimental applications, and have distributed them to the Developmental Studies Hybridoma Bank (DSHB) and several commercial suppliers. This study allowed us to perform a meta-analysis that identified critical variables that contribute to the generation of high quality mAbs. We find that using full-length antigens for immunization, in combination with HuProt™ analysis, provides the highest overall success rates. The efficiencies built into this pipeline ensure substantial cost savings compared to current standard practices.
Audit quality and audit report lag: case of Indonesian listed companies
Authors: Rusmin Rusmin , Evans John 
Published: March 2017

Purpose
The purpose of this paper is to empirically examine the relation between two dimensions of auditor quality, namely, auditor industry specialization and auditor reputation and the audit report lag.

Design/methodology/approach
The data collection focuses on companies listed on the Indonesia Stock Exchange for the financial year of 2010 and 2011. To ensure data homogeneity and reduce industry bias, this study focuses solely on manufacturing companies identified by the Indonesian Capital Market Directory.

Findings
This study finds a negative and significant association between industry-specialist auditors and audit report timeliness. Companies audited by industry-specialist auditors have shorter audit delays. The authors also find evidence that Big 4 auditors perform significantly faster audit work than their non-Big 4 counterparts. In addition, this study reports a statistical and significant relationship between auditing complexity, companies’ profitability, auditors’ business risk, and industry classification and audit report lag. The results show that firms with a large number of subsidiaries and firms experiencing poorer financial performance are found to be associated with longer reporting delays. Moreover, audit report timeliness is found to be faster for companies in the low-profile industry sector and owned by family members.

Research limitations/implications
Similar to other empirical investigations, this study is not without certain caveats. First, the period of audit report lag in this study reflects the audit work from the year-end to the audit report date. The authors do not consider audit work conducted outside this period in the analysis. Second, there are numerous control variables and although the authors have attempted to capture those variables to maintain the integrity of the research there are likely other excluded variables that may be important in explaining audit report timeliness. Finally, there are other factors, for example, an administrative approval process with the audit firm home office, which can affect audit report lags but have not been included in the model analysis. Future studies can seek to focus on refinements to the proxy measures for dependent and experimental variables.

Practical implications
Insights drawn from this study may be of assistance to policy makers as they consider the costs and benefits associated with varying levels of audit market concentration as well as providing a snapshot of the level of non-compliance on audit timeliness in Indonesia.

Originality/value
This study provides further empirical evidence on the relation between auditor quality and audit report lag using data from a different domestic setting. This study also enriches the auditor quality literature by employing industry-specialist and Big 4 auditors as a predictor for the timeliness of audit reports.
Strategic agility explanations for managing franchising expansion during economic cycles
Authors: Alon Ilan , Madanoglu Melih , Shoham Amir 
Published: March 2017

PurposeThis paper aims to demonstrate how franchising firms can manage system expansion by weathering the economic effects of a location (i.e. country-level economic cycles) by shifting their resources.Design/methodology/approachThe authors use a comprehensive database of 151 US hybrid franchising organizations, including observations for the years between 2001 and 2008. Data analysis is conducted with count model panel data with a Poisson distribution.FindingsThe model reveals a curvilinear U-shaped relationship between location (i.e. economic cycles) and franchising expansion.Originality/valueThis study contributes to competitiveness literature by showing how franchising firms respond to changing local conditions.
International spectrum management regime: is gridlock blocking flexible spectrum property rights?
Authors: El-Moghazi Mohamed , Whalley Jason , Irvine James 
Published: March 2017

Purpose
This paper aims to examine the influence of the international spectrum management regime on the introduction of flexibility in the national allocation of radiocommunication services. This is achieved through focusing on the main elements of the international regime.

Design/methodology/approach
A qualitative inductive methodology is adopted that examines the different elements of the international radiocommunication service allocation framework. Data are drawn from 66 semi-structured interviews with key stakeholders who are actively involved in International Telecommunication Union Radiocommunication Sector discussions.

Findings
The international radio regulations (RR) are perceived to be more of a framework for harmonisation that does not constrain the flexibility of countries. Countries are only restricted on their borders with their neighbours, and flexibility is already facilitated through a range of different measures. Moreover, several elements of the RR can be used to achieve both, i.e. to promote flexibility and to restrict the decisions of others.

Practical implications
The international spectrum management regime is not one of the reasons for the unsuccessful practical application of the flexible spectrum property rights concept. This suggests the need for reviewing whether there still is a need for such a concept given the increasing importance of global harmonisation and economies of scales.

Originality/value
This paper sheds light on spectrum property rights from the perspective of the international spectrum management regime. Such a perspective is largely overlooked in the on-going current debate.
How do new ventures attract and retain talented employees? The case of Shaadisaga
Authors: Batra Safal 
Published: March 2017

PurposeThis paper aims to make an attempt to highlight how small businesses and new ventures, which are invariably resource-constrained and cannot match the salaries of their larger counterparts, attract and retain talented employees. The study uses the setting of a new Indian venture called Shaadisaga to demonstrate successful employee development practices for new ventures.Design/methodology/approachFindings are based on in-depth interviews with the team of Shaadisaga.FindingsFindings reveal that new ventures – which operate with limited resources and market presence – need to leverage their human resources to their highest potential. The only way to hire and retain good talent is to keep the employees motivated, offer challenging assignments which enhance their learning and skills and make them partners of the growth story of the company.Practical implicationsManagers and entrepreneurs who are building new ventures need to pay special attention to the development of their employees. Long-term promising careers, challenging assignments, diverse roles and a share in the growth of the company can help organizations retain good talent and get the best out of them.Originality/valueExtant research offers insights into how to manage and motivate people in large organizations. However, little is still known about the management practices of new ventures, especially of those operating in the emerging economies. This study tries to highlight the human resource practices of a new venture that has been successfully building a team of motivated employees delivering to the expectations of the organization.
Determinants of health at work in the EU15
Authors: Coupaud Marine 
Published: March 2017

PurposeWorkers’ health is a main concern in industrialized countries. The structural evolution of the labor market should have encouraged better working conditions, as should have increasing interest in corporate social responsibility. But work arduousness takes new forms as work organizations evolve. All workers are potentially affected by onerous working conditions. The purpose of this paper is to explore all types of working conditions that may affect workers.Design/methodology/approachThe author creates four indicators of working conditions using the multiple correspondence analysis and also analyzes how they relate to the workers’ physical and mental health using a logit model.FindingsPerforming the analysis on data from the third and fifth waves of the European Working Conditions Survey, the author presents the results showing the growing importance of interpersonal relationships at work and observes a rise in inequalities in terms of health over the period 2000-2010 for people belonging to the vulnerable categories: women and lower-income groups.Originality/valueThe author offers to describe the evolution of the working conditions of the European workers over an interesting period during which many changes took place. Moreover, this paper investigates the respective impacts of different types of working conditions to come up with policy recommendations.
The impact of product complexity and variety on supply chain integration
Authors: Shou Yongyi , Li Ying , Park Young Won , Kang Mingu 
Published: March 2017

PurposeThe purpose of this paper is to examine the antecedents of supply chain integration (SCI) at the product level. More specifically, it aims to show the relationship between product-level characteristics (i.e. product complexity and product variety) and different dimensions of SCI (i.e. internal, supplier and customer integration).Design/methodology/approachA survey-based research design is developed to measure different dimensions of SCI, product complexity and product variety. The authors use structural equation modelling to test the related hypotheses.FindingsThis research shows that internal integration is an enabler to supplier and customer integration. The results also show that under high product complexity, firms tend to implement internal and supplier integration, while product complexity does not have a direct impact on customer integration. Product variety is confirmed to be positively related to all dimensions of SCI.Originality/valueThis paper contributes to the SCI literature by first, providing empirical evidence which supports the study of the product design-supply chain interface; and second, exploring the relationships between product complexity, variety and internal, supplier and customer integration based on a governance view.
The electrical impedance measurements of dry electrode materials for the ECG measuring after repeated washing
Authors: Kaappa Emma Sofia , Joutsen Atte , Cömert Alper , Vanhala Jukka 
Published: March 2017

Purpose
The purpose of this paper was to offer more reliable dry electrode materials for long-term measuring and determine how repeated machine washing affects the measured impedance and surface resistance of the sample electrodes. The aim was to manufacture electrodes that could be used for the measurement of ECG. Skin friendly, metal sheet type, electrodes could be a solution.

Design/methodology/approach
In addition to two conventional electrodes already used in heart rate belts, the authors prepared and tested three different sheet metal electrodes. Three 20-mm-diameter electrodes were manufactured from the following materials: silvered knit, conductive polymer, stainless steel, silver and platinum. Electrode impedance was measured at seven frequencies from 1 Hz to 1 MHz, by placing two electrodes face-to-face. Measurements were taken on unused electrodes and after multiple machine washes at 40°C.

Findings
Analysis of the measurements indicates that with every material tested, the impedances are elevated after repeated washes. All metallic materials have impedances in the range of 0.01 to 4.5 Ω. Metal sheet electrodes can be integrated comfortably into the textile, and they endure textile maintenance without loss of electrical properties.

Practical implications
Metal sheet electrodes function well in long-term vital signs monitoring, provide a reliable signal and are resistant to maintenance. For the reasons described in this research, they can be used as a long-term wearable sensor.

Originality/value
Novel electrode material for long-term measuring research is important in many disciplines such as health care and apparel manufacturing. These findings suggest that pure metal electrodes are better than conductive textiles in long-term measuring.
Commodity Dependence and Human Development
Authors: Nkurunziza Janvier D. , Tsowou Komi , Cazzaniga Sofia 
Published: March 2017

AbstractThis paper explores the relationship between commodity dependence and human development measured by the human development index (HDI). Commodity dependence negatively affects human development through several channels, including the negative secular terms of trade affecting commodity‐dependent developing countries (CDDCs), slow economic growth, high macroeconomic instability, and political instability. The paper finds that although the effect of commodity dependence on human development is negative, on average, this relationship is complex. It changes with the level of dependence as well as the type of commodity a country depends on. This negative effect is strongest in countries where commodities account for more than 60 percent of total merchandise exports.
Core themes in textbook definitions of physical geography
Authors: Day Terence 
Published: March 2017

Key Messages

Contemporary physical geography has core themes that define the subject as it is taught at the undergraduate level in North America and the United Kingdom.
Physical geography textbooks have responded well to the emerging theme of anthropogenic processes.
These textbooks, however, struggle to represent coherent perspectives on space, the uniqueness of places, and the apparent contradiction of physical geography as a science.
On Faith, Merit, and Eternal Life
Authors: Vainio Olli‐Pekka 
Published: March 2017

AbstractCan eternal life be merited? The traditional Lutheran answer to this question has been negative. However, the question is not as simple as it first seems. For example, recently, Mats Wahlberg has argued that Lutherans should admit that eternal life can be merited, especially if they support the “Finnish Luther interpretation.” Although I find much to commend in Wahlberg's reading, there are at least two problems in his proposal. First, the language of merit is tied to a particular philosophical framework that is not shared ecumenically; and second, all Lutherans do not share all the details of the Finnish reading of Luther. However, both Wahlberg's proposal and the Finnish interpretation of Luther have genuine ecumenical potential if they are developed so that they can address the concerns related to the philosophy of action and Christian life.
Interactive audience response systems in oral and maxillofacial radiology undergraduate lectures
Authors: de Oliveira‐Santos Christiano , Tirapelli Camila , Rodrigues Clarissa Teles , Domaneschi Carina , Caldeira Monteiro Solange Aparecida 
Published: March 2017

AbstractObjectivesTo evaluate the impact of audience response systems (ARS) on student participation (SP) during Oral and Maxillofacial Radiology (OMR) undergraduate lectures and on final examination scores (FES). Furthermore, an analysis of unanimity assessed the influence of ARS on students’ responses. Students’ perceptions were also assessed.MethodsA controlled crossover study was designed. Four lectures covering topics of OMR were each taught with ARS and without ARS (i.e. hand‐raising method). SP and FES were compared between ARS and HR groups. Unanimity of answers was analyzed for both groups. Questionnaires assessed students’ impressions about ARS.ResultsMean SP of ARS and HR groups were 97.6% and 47.3%, respectively, and this difference was statistically significant (P<.05). Mean FES for the ARS group (77%) was slightly higher than HR group (75.1%), however, not statistically significant. There was positive correlation between SP and FES. With ARS, only 5.7% of the questions were unanimous, whilst 51.4% were unanimous with HR method. Most students reported that the use of ARS had positive influence on their attention (92%), participation (96%), classmates’ participation (82.7%), interest (74.7%), and learning (86.7%). For the five‐point scale ratings of the relevance of ARS features, anonymity had an average 3.6, whilst other items received an average 4.6 or higher.ConclusionsARS significantly increased participation in OMR lectures; however, an increase in FES could not be associated with ARS by itself. Not taking into consideration which method was used to answer questions posed during lectures, higher participation correlated with higher scores. ARS is well‐accepted and students believe that these devices positively influence their performance. Among the recognized advantages of ARS, anonymity was considered the least relevant.
Formative evaluation of a teledentistry training programme for oral health professionals
Authors: McFarland K. K. , Nayar P. , Chandak A. , Gupta N. 
Published: March 2017

AbstractIntroductionThe objective of this study was to conduct a formative evaluation of a teledentistry (TD) programme that was developed for a predominantly rural state in the Midwestern United States.Materials and MethodsFormative evaluation data were collected on programme activities from the TD programme records. In addition, the effectiveness of the TD training programme was evaluated using a self‐administered paper‐based survey administered to the participants, immediately following completion of the training activity. Ninety‐three dental students, oral health and other health professionals participated in the TD training programme.ResultsOverall, the trainees rated the TD training programme highly, with regard to the content, format and skills improvement. The evaluation also demonstrated a positive change in all trainees’ attitudes following the training sessions, with most trainees acknowledging a positive impact of the training on their knowledge and competency.Discussion and ConclusionsWe identified challenges in the development of the TD programme and in expanding access to oral health care for rural communities. Challenges included reimbursement and a limited interest amongst established dental offices. Dental schools can play an important role in preparing both dental health professionals and other health professionals in the use of TD by providing training and oral health expertise. The use of TD by non‐dental providers for consultation, referral and disease management has the potential to improve oral health outcomes, particularly for rural and underserved populations. Evaluation data provide critical feedback to programme planners and administrators.
Non‐obstructive carotid atherosclerosis and patent foramen ovale in young adults with cryptogenic stroke
Authors: Jaffre A. , Guidolin B. , Ruidavets J.‐B. , Nasr N. , Larrue V. 
Published: March 2017

Background and purposeUp to 50% of ischaemic strokes in young adults are classified as cryptogenic despite extensive work‐up. We sought to evaluate the prevalence of non‐obstructive carotid atherosclerosis (NOCA) and its association with patent foramen ovale (PFO) in young adults with cryptogenic stroke (CS).MethodsPatients aged 18–54 years, consecutively treated for first‐ever CS in an academic stroke service, were included. NOCA was assessed using carotid ultrasound examination and was defined as carotid plaque with <50% stenosis. PFO was diagnosed with transesophageal echocardiography.ResultsA total of 164 patients [mean age (SD) = 43.7 (8.5) years; 104 men] were included. A PFO was found in 79/164 (48.2%) patients. NOCA was demonstrated in 41/164 (25%) patients. NOCA was more common in patients without PFO [37.6% vs. 11.4%, P < 0.001; adjusted odds ratio (95% confidence interval), 0.24 (0.10–0.56)]. Older age (P = 0.046) and subcortical location of cerebral infarct (P = 0.015) were also associated with the absence of PFO, whereas hypertension, diabetes and smoking were not.ConclusionsThis study demonstrates that NOCA is common in young adults with CS. NOCA is negatively associated with PFO. Detecting NOCA is an important component of stroke investigation in young adults.
Pyoderma gangrenosum: clinical characteristics, associated diseases, and responses to treatment in a retrospective cohort study of 31 patients
Authors: Vacas Aldana S. , Torre Ana C. , Bollea‐Garlatti María L. , Warley Fernando , Galimberti Ricardo L. 
Published: March 2017

AbstractObjectiveThe aim of this study was to describe the clinical characteristics of patients with pyoderma gangrenosum (PG) and to evaluate the association between these characteristics, the treatment followed, and the patient responses, relapses, and mortality rates.Material and methodsThis retrospective cohort study identified adults diagnosed with pyoderma gangrenosum over the duration of 10 years.ResultsThirty‐one patients were evaluated; 58% were women and 55% were older than 65 years, 87% presented with the ulcerative type, and 77% showed lower limb compromise. Approximately 74% of the cases were associated with systemic disease. The most frequent were inflammatory bowel disease (32%) and hematologic malignancies (22%). Pyoderma gangrenosum preceded the associated disease in 26% of the patients, all of them were younger than 50 years old (P = 0.059). In 83% of the latter, the diagnosis of associated disease followed the cutaneous lesions within 24 months. Among the 10 patients with inflammatory bowel disease, six required biologic agents to control the pyoderma gangrenosum (P = 0.002).ConclusionDespite the advances that have been made in the treatment of patients with pyoderma gangrenosum, we are still unclear as to the optimal way in which patients should be followed up once the diagnosis is made. The results of our study underline the importance of doing screening tests to detect potential disease, emphasizing patients younger than 50 years old, for a minimum time lapse of 24 months. It is essential to design randomized‐controlled trials to understand the most appropriate and effective ways of following up patients with pyoderma gangrenosum.