bluuebunny/crossref_metadata_2025_split huggingface dataset:
From Labquakes to Megathrusts: Scaling Deep Learning Based Pickers Over 15 Orders of Magnitude
Authors: Shi Peidong , Meier Men‐Andrin , Villiger Linus , Tuinstra Katinka , Selvadurai Paul Antony , Lanza Federica , Yuan Sanyi , Obermann Anne , Mesimeri Maria , Münchmeyer Jannes , Bianchi Patrick , Wiemer Stefan 
Published: October 2024

AbstractThe application of machine learning techniques in seismology has greatly advanced seismological analysis, especially for earthquake detection and seismic phase picking. However, machine learning approaches still face challenges in generalizing to data sets that differ from their original training setting. Previous studies focused on retraining or transfer‐learning models for these scenarios, but require high‐quality labeled data sets. This paper demonstrates a new approach for augmenting already trained models without the need for additional training data. We propose four strategies—rescaling, model aggregation, shifting, and filtering—to enhance the performance of pre‐trained models on out‐of‐distribution data sets. We further devise various methodologies to ensemble the individual predictions from these strategies to obtain a final unified prediction result featuring prediction robustness and detection sensitivity. We develop an open‐source Python module quakephase that implements these methods and can flexibly process input continuous seismic data of any sampling rate. With quakephase and pre‐trained ML models from SeisBench, we perform systematic benchmark tests on data recorded by different types of instruments, ranging from acoustic emission sensors to distributed acoustic sensing, and collected at different scales, spanning from laboratory acoustic emission events to major tectonic earthquakes. Our tests highlight that rescaling is essential for dealing with small‐magnitude seismic events recorded at high sampling rates as well as larger magnitude events having long coda and remote events with long wave trains. Our results demonstrate that the proposed methods are effective in augmenting pre‐trained models for out‐of‐distribution data sets, especially in scenarios with limited labeled data for transfer learning.
Parent-perceived oral habits among a group of school children: prevalence and predictors
Authors: Khattab Nagwa Mohamed Ali , Abd-Elsabour Mennat Allah Ashraf , Omar Ola Moustafa 
Published: October 2024

Abstract
Purpose
Practicing oral habits beyond the normal age range is assumed to be due to underlying psychological disturbance and could result in a deformation of the orofacial structure. The first step in managing such a health condition is to evaluate its size. Thus, this study aimed primarily to assess the prevalence of oral habits among a group of school children aged from 5 to 7 years, in Cairo, Egypt. The secondary aim of the study was to investigate some possible related predictors along with the mother’s perception of the child’s oral health-related quality of life.

Methods
A Google form questionnaire was designed, utilizing the third domain of Nordic Orofacial Test-Screen (NOT-S), to assess the presence or absence of oral habits and their types, if reported. Also, there were two global rating items to test the child’s oral health-related quality of life from the mother’s prospection, along with one item to inquire if the mother thinks that the oral habits are harmful to the child. A total number of 23 schools in Cairo, Egypt were randomly selected, and the link to the Google form was distributed through the parent’s groups on social media. All high-quality complete responses were analyzed using the SPSS program, and a Log-binomial regression model was constructed, to determine the significant predictors of practicing oral habits in children.

Results
Among the analyzed 1128 responses, the total number of answers to the third domain of interview part of NOT-S was 1235, with a response rate of (60.39%), no habits were reported in 635 children (51.4%), while nail biting was noted in 21.8%, bruxism in 17.9% and Sucking habits in 8.9%. In total, 63.8% of children who were reported by their parents to be the “only child” didn’t practice any habit, and a higher prevalence of oral habits was detected in children with siblings. There was no detectable association between the mother’s educational level and practicing any of the habits, although there was an association between the mother’s educational level and their awareness of the harmful effect of oral habits on the child. The mothers’ answers to the global rating items were not associated with any of the oral habits.

Conclusion
The most prevalent oral habit in the current study was the nail-biting habit. The presence of other siblings and the number of siblings were contributory factors in the occurrence of oral habits, while mothers’ educational level was not associated with practicing oral habits. The mothers’ awareness of the harmful effect of oral habits on the children was not satisfactory, and there was no association between oral health-related quality of life and the children’s oral habits, from the mothers’ perspective.
A novel methodology for analysing dental implant positional changes from virtual planning to placement without CBCT
Authors: Nulty Adam B. 
Published: October 2024

AbstractIntroduction This paper introduces a novel methodology for analysing dental implant positioning in vivo, advancing beyond traditional methods that rely on post-placement cone beam computed tomography (CBCT) scans.Method The core of the methodology is comparing stereolithography (STL) files, representing pre-planned and actual post-placement implant positions. These STL files, exported from guided surgery planning and computer-aided design software, focus on clinically significant key points, like the apical and coronal midpoints. Additionally, the method uses pose detection, differing fundamentally from CBCT scan approximations.Discussion Relying on pose detection instead of scanner resolution, this method aligns with international standards and overcomes CBCT and intra-oral scanner limitations. It allows for a more precise and accurate assessment of implant positions, independent of scanner technology constraints. Further refinements include potential detailed reporting of apical deviations, enhancing implant placement accuracy.Conclusion This research has significant implications for dental implantology, enhancing implant placement precision and overall procedure success. Introducing an automated process for report generation through a batch script improves efficiency and precision, streamlining the analysis process. This innovation sets the stage for future technological advancements, improving both the accuracy and reliability of implant placement assessments.
What are the public health benefits of community-based education in dentistry? A scoping review
Authors: Ayibuofu-Uwandi Vivian , Dyer Thomas A. 
Published: October 2024

AbstractAim To examine what is known about the public health benefits of community-based education in dentistry.Method A scoping review was conducted using a modified Arksey and O'Malley framework. Database searches were undertaken on PubMed, Medline via Ovid, CINAHL via EBSCO and ERIC, and a grey literature search was undertaken on OpenGrey, Medlar, BASE and the British Library. Reference lists of included studies were also searched. Although no formal quality assessment was undertaken, observations on methodological rigour were recorded.Results In total, 31 studies from nine countries met the inclusion criteria. Most were from high-income countries. Methodologies of included studies varied: quantitative (n = 17); qualitative (n = 5); mixed methods (n = 6); and reviews (n = 3). Several potential public health benefits were reported: increased access to dental services (including improvements in their availability, affordability, acceptability, accessibility, and accommodation); improved awareness/health literacy of students and communities; and improved clinical outcomes. The overall quality of the evidence was low and had little community engagement.Conclusion Notwithstanding the methodological limitations of the included studies, several potential public health benefits have been associated with community-based education in dentistry. Rigorously designed, methodologically appropriate research is needed, which should include engagement with communities.
The αvβ6 integrin specific virotherapy, Ad5NULL-A20.FCU1, selectively delivers potent “in-tumour” chemotherapy to pancreatic ductal adenocarcinoma
Authors: Badder Luned M. , Davies James A. , Meniel Valerie S. , Marušková Mahulena , Salvador-Barbero Beatriz , Bayliss Rebecca J. , Phesse Toby J. , Hogan Catherine , Parker Alan L. 
Published: October 2024

Abstract
Background
Pancreatic ductal adenocarcinoma (PDAC) represent an unmet clinical need. Approximately 90% of PDACs express high levels of αvβ6 integrin. We have previously described Ad5NULL-A20, an adenovirus vector with ablated native means of cell entry and retargeted to αvβ6 integrin by incorporation of an A20 peptide.

Methods
Here, we incorporate suicide genes FCY1 and FCU1 encoding for cytosine deaminase (CDase) or a combination of CDase and UPRTase, capable of catalysing a non-toxic prodrug, 5-FC into the chemotherapeutic 5-FU and downstream metabolites, into replication-deficient Ad5 and Ad5NULL-A20.

Results
We show that Ad5NULL-A20 enables the transfer of suicide genes to αvβ6 integrin-positive PDAC cells which, in combination with 5-FC, results in cell death in vitro which is further mediated by a bystander effect in non-transduced cells. Intratumoural delivery of Ad5NULL-A20.FCU1 in combination with intraperitoneal delivery of 5-FC further results in tumour growth inhibition in a cell line xenograft in vivo. Using clinically-relevant 3D organoid models, we show selective transduction and therapeutic efficacy of FCU1 transgenes in combination with 5-FC.

Conclusion
Taken together these data provide the preclinical rationale for combined Ad5NULL-A20.FCU1 plus 5-FC as a promising targeted therapy to mediate “in-tumour chemotherapy” and merits further investigation for the treatment of PDAC patients.
The phonon-modulated Jahn–Teller distortion of the nitrogen vacancy center in diamond
Authors: Carbery William P. , Farfan Camille A. , Ulbricht Ronald , Turner Daniel B. 
Published: October 2024

AbstractThe negatively charged nitrogen vacancy (NV) center in diamond is an optically accessible material defect with a unique combination of spin and optical properties that has attracted interest in quantum-information sciences and as a design candidate for nanoscale quantum sensors. Here, we present time-resolved nonlinear optical spectroscopy measurements, conducted with ultrabroadband laser pulses, that reveal strong modulation of the excited-state by the longitudinal optical (LO) phonon of the diamond lattice. The LO phonon and its overtones geometrically distort neighboring NV centers, driving long lived (3.5 ps) excited state relaxation of coupled NV centers after the initial excitation and ultrafast (<150 fs) decay of the Jahn–Teller distortion. These observations elevate the LO phonon to an important tuning mode of the Jahn–Teller conical intersection and help resolve previous spectroscopy experiments that noted longer-lived excited-state dynamics.
Effects of iron supplements and iron-containing micronutrient powders on the gut microbiome in Bangladeshi infants: a randomized controlled trial
Authors: Baldi Andrew , Braat Sabine , Hasan Mohammed Imrul , Bennett Cavan , Barrios Marilou , Jones Naomi , Abdul Azeez Imadh , Wilcox Stephen , Roy Pradip Kumar , Bhuiyan Mohammad Saiful Alam , Ataide Ricardo , Clucas Danielle , Larson Leila M. , Hamadani Jena , Zimmermann Michael , Bowden Rory , Jex Aaron , Biggs Beverley-Ann , Pasricha Sant-Rayn 
Published: October 2024

AbstractAnemia is highly prevalent globally, especially in young children in low-income countries, where it often overlaps with a high burden of diarrheal disease. Distribution of iron interventions (as supplements or iron-containing multiple micronutrient powders, MNPs) is a key anemia reduction strategy. Small studies in Africa indicate iron may reprofile the gut microbiome towards pathogenic species. We seek to evaluate the safety of iron and MNPs based on their effects on diversity, composition, and function of the gut microbiome in children in rural Bangladesh as part of a large placebo-controlled randomized controlled trial of iron or MNPs given for 3 months (ACTRN12617000660381). In 923 infants, we evaluate the microbiome before, immediately following, and nine months after interventions, using 16S rRNA gene sequencing and shotgun metagenomics in a subset. We identify no increase in diarrhea with either treatment. In our primary analysis, neither iron nor MNPs alter gut microbiome diversity or composition. However, when not adjusting for multiple comparisons, compared to placebo, children receiving iron and MNPs exhibit reductions in commensal species (e.g., Bifidobacterium, Lactobacillus) and increases in potential pathogens, including Clostridium. These increases are most evident in children with baseline iron repletion and are further supported by trend-based statistical analyses.
Sport mental health continuum in young Brazilian athletes: adaptation and psychometric properties
Authors: Tozetto Willen Remon , Milan Fabrício João , Lima Cláudio Olivio Vilela , Milistetd Michel 
Published: October 2024

AbstractInstruments used to assess the mental well-being of young athletes in Brazil are scarce. Therefore, the present study aimed to translate, cross-culturally adapt for young athletes, and gather evidence of validity for the Sport Mental Health—Short Form (S-MHC) for use in Brazilian Portuguese. The research was conducted in five stages: translation, synthesis, back-translation, expert review, and validation of the psychometric properties. For validation, 246 young athletes of both genders (88 females, 35.8%), aged between 12 and 18 years (14.5 ± 1.9 years), were recruited. Psychometric methods were employed to confirm and validate the translated and adapted versions of the S-MHC for young athletes, including internal consistency using Cronbach's alpha and McDonald's omega, composite reliability, Item Characteristic Curve (ICC) using Item Response Theory (IRT), and Confirmatory Factor Analysis (CFA). Two structures were tested, with Model 1 loading the 14 items of the translated version of the S-MHC into a single latent factor and Model 2 loading the items into three factors related to emotional, social, and psychological sport well-being. Both models showed good validity, consistency, and reliability measures and can be used to investigate the sport well-being of young athletes. It was concluded that the translated version of the S-MHC in Brazilian Portuguese can be used to assess the sport well-being of young athletes in Brazil. Model 2 structure is recommended to observe the different nuances of emotional, social, and psychological well-being.
Synthesis and characterization of some new Schiff base azo disperse dyes based on chromene moiety for simultaneous dyeing and antimicrobial finishing
Authors: Fathy Hagar , Helal M. H. , Abbas Dina , Mohamed Fatma A. 
Published: October 2024

AbstractNew azo Schiff base disperse dyes based on a chromene moiety were synthesized by reacting (2-amino-7-hydroxy-4-(4-methoxyphenyl)-4 H-chromene-3 carbonitrile) and(2-amino-4-(3,4-dimethoxyphenyl)-7-hydroxy-4 H-chromene-3-carbonitrile), with vanillin and ninhydrin, producing new chromene Schiff base derivatives, which in turn were coupled with 2-chloro-4-nitroaniline diazonium salt to give new 4 azo disperse dyes (1–4). The structures of the prepared dyes were confirmed using elemental analysis, 1HNMR spectroscopy, mass spectrometry, and IR. The synthesized dyes were applied to polyester and nylon fabrics using different dyeing techniques: high temperature- high pressure, and ultrasonic dyeing methods. The highest K/S values for all investigated dyes were achieved usinga high temperature-high pressure dyeing technique. Also, the color reflectance of all synthesized dyes with different dyeing shades (1%, 2%, and 3%) was obtained. The fastness properties of the dyed samples using the investigated dyes showed good color fastness toward light, washing, rubbing, and perspiration fastness. The presence of a chromene moiety and Schiff base in the investigated dyes promotes a higher antimicrobial activity on nylon and polyester fabrics against all tested bacteria (E. coli gram-negative and Staphylococcus aureus gram-positive) and two fungi, Aspergillus Niger and Candida albicans.
Incorporating date palm fibers for sustainable friction composites in vehicle brakes
Authors: Ammar Zeina , Adly Mahmoud , Abdalakrim Somia Yassin Hussain , Mehanny Sherif 
Published: October 2024

AbstractThe demand for eco-friendly materials in automotive components has spurred research into natural fibers as sustainable alternatives for brake pads. This study examines the potential of date palm fibers, particularly the palm frond midrib (PFM), in brake pad composites. The effects of epoxy, PFM, and calcium carbonate on the composites’ mechanical and tribological properties were analyzed. The optimal formulation (25% epoxy, 30% PFM, 35% calcium carbonate) exhibited superior properties, including a hardness of 87 HRB, wear rate of 1.5E-03 mg/mm, and COF of 0.73, surpassing commercial pads. Additionally, an inverse relationship between PFM/calcium carbonate content and compressibility was observed, with increased calcium carbonate enhancing wear resistance. This research underscores the potential of utilizing date palm resources in eco-friendly brake manufacturing, reducing the environmental and health impacts of traditional materials.
Comparative analysis of the influence of BpfA and BpfG on biofilm development and current density in Shewanella oneidensis under oxic, fumarate- and anode-respiring conditions
Authors: Klein Edina Marlen , Heintz Hannah , Wurst René , Schuldt Simon , Hähl Hendrik , Jacobs Karin , Gescher Johannes 
Published: October 2024

AbstractBiofilm formation by Shewanella oneidensis has been extensively studied under oxic conditions; however, relatively little is known about biofilm formation under anoxic conditions and how biofilm architecture and composition can positively influence current generation in bioelectrochemical systems. In this study, we utilized a recently developed microfluidic biofilm analysis setup with automated 3D imaging to investigate the effects of extracellular electron acceptors and synthetic modifications to the extracellular polymeric matrix on biofilm formation. Our results with the wild type strain demonstrate robust biofilm formation even under anoxic conditions when fumarate is used as the electron acceptor. However, this pattern shifts when a graphite electrode is employed as the electron acceptor, resulting in biofilm formation falling below the detection limit of the optical coherence tomography imaging system. To manipulate biofilm formation, we aimed to express BpfG with a single amino acid substitution in the catalytic center (C116S) and to overexpress bpfA. Our analyses indicate that, under oxic conditions, overarching mechanisms predominantly influence biofilm development, rather than the specific mutations we investigated. Under anoxic conditions, the bpfG mutation led to a quantitative increase in biofilm formation, but both strains exhibited significant qualitative changes in biofilm architecture compared to the controls. When an anode was used as the sole electron acceptor, both the bpfA and bpfG mutations positively impacted mean current density, yielding a 1.8-fold increase for each mutation.
Defected photonic crystal as propylene glycol THz sensor using parity-time symmetry
Authors: Zaky Zaky A. , Al-Dossari M. , Zhaketov V. D. , Aly Arafa H. 
Published: October 2024

AbstractDetecting unsafe levels of chemical gases and vapors is essential in improving and maintaining a healthy environment for all to enjoy. Propylene glycol is a colorless, synthetic gas commonly used in medications, fragrances, and cosmetics. It causes side effects such as headaches, lightheadedness, nausea, and fainting. So, monitoring of propylene glycol is critically vital. This study uses a defected photonic crystal as a propylene glycol THz sensor. Due to the high absorption of propylene glycol, the intensity of the resonant confined mode is very small. As a result, the performance of the designed sensor seems unsatisfactory. We will use parity-time symmetry for the first time in THz to magnify the resonant confined mode to detect propylene glycol. The effect of microcavity thickness, incident angle, and gain/loss factor will be studied. The optimized sensor recorded distinguished results compared to other studies for the detection of propylene glycol.
Characterizing the allele-specific gene expression landscape in high hyperdiploid acute lymphoblastic leukemia with BASE
Authors: Andersson Jonas , Aydın Efe , Gunnarsson Rebeqa , Lilljebjörn Henrik , Fioretos Thoas , Johansson Bertil , Paulsson Kajsa , Yang Minjun 
Published: October 2024

AbstractSomatic copy number variations (CNVs), including abnormal chromosome numbers and structural changes leading to gain or loss of genetic material, play a crucial role in initiation and progression of cancer. CNVs are believed to cause gene dosage imbalances and modify cis-regulatory elements, leading to allelic expression imbalances in genes that influence cell division and thereby contribute to cancer development. However, the impact of CNVs on allelic gene expression in cancer remains unclear. Allele-specific expression (ASE) analysis, a potent method for investigating genome-wide allelic imbalance profiles in tumors, assesses the relative expression of two alleles using high-throughput sequencing data. However, many existing methods for gene-level ASE detection rely on only RNA sequencing data, which present challenges in interpreting the genetic mechanisms underlying ASE in cancer. To address this issue, we developed a robust framework that integrates allele-specific copy number calls into ASE calling algorithms by leveraging paired genome and transcriptome data from the same sample. This integration enhances the interpretability of the genetic mechanisms driving ASE, thereby facilitating the identification of driver events triggered by CNVs in cancer. In this study, we utilized BASE to conduct a comprehensive analysis of ASE in high hyperdiploid acute lymphoblastic leukemia (HeH ALL), a prevalent childhood malignancy characterized by gains of chromosomes X, 4, 6, 10, 14, 17, 18, and 21. Our analysis unveiled the comprehensive ASE landscape in HeH ALL. Through a multi-perspective examination of HeH ASEs, we offer a systematic understanding of how CNVs impact ASE in HeH, providing valuable insights to guide ASE studies in cancer.