bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simulación y evaluación de una voladura de producción en una cantera mediante análisis con el software JKSimBlast, perfilometría láser 2D y sismógrafos.
Authors: Morato Medina Antonio , Cebrián Romo Benjamín 
Published: June 2017

En la cantera de árido de estudio se extrae roca caliza para su explotación como material de construcción. La función principal de las voladuras de producción es obtener mediante el uso de explosivos civiles, un tamaño de bloque adecuado para la planta de trituración, conseguir un frente de talud estable, bien marcado y rectilíneo para garantizar la estabilidad de la explotación y minimizar las vibraciones en las estructuras y zonas de interés circundantes. Para ello se define una voladura tipo en la que se simulan y evalúan los principales parámetros de diseño mediante el uso del software JKSimBlast, un perfilómetro 2D y dos sismógrafos, buscando conciliar una producción óptima con un nivel mínimo de vibraciones en las zonas a monitorear. AbstractAt the studied quarry, limestone is extracted for its exploitation as construction material. The main functions of production blasts are to obtain, by using civil explosives, a suitable block size for the crushing plant, to achieve a stable, well-marked and rectilinear slope, to guarantee the stability of the operation and to minimize the vibrations in the surrounding structures and areas of interest. For this, a type blast is defined in which the main design parameters are simulated and evaluated using JKSimBlast software, a 2D profiler and two seismographs, seeking to reconcile optimal production with a minimum level of vibration in the areas to be monitored.
Estrategias de comercialización de las distribuidoras de productos de consumo masivo de la provincia de Santa Elena.
Authors: Vera Campuzano Nury , Ventura Suárez Alba , Fortis Suárez Joel , Andrade Vera Alicia , Santos Tomalá Julia , Collins Ventura Nathyn 
Published: June 2017

El objetivo del presente artículo consiste en diagnosticar la percepción de los consumidores de las distribuidoras de productos de consumo masivo de la provincia de Santa Elena. La contribución teórica radica en la concepción de la teoría y práctica en las acciones estratégicas de comercialización atendiendo al contexto, la definición y caracterización de la gestión de marketing, con el fin de determinar los factores decisorios y de éxito para las empresas, constituye el aporte teórico para argumentar la investigación realizada. Se realizó una investigación exploratoria dirigida a consumidores de productos masivos de entre 20 y 54 años de la provincia de Santa Elena y se realizó entrevistas a tres representantes de distribuidoras de productos de consumo masivo. Los resultados recomiendan que con la aplicación de estrategias de comercialización asertivas basadas en las preferencias del grupo meta, y tendencias del mercado, se mejoraría el desempeño organizacional, mediante la captación de prospectos, y generación de lazos de fidelización de clientes actuales. AbstractThe objective of the present scientific article is to diagnose the perception of the consumers of the distributors of products of mass consumption of the province of Santa Elena. The theoretical contribution lies in the conception of theory and practice in strategic marketing actions, taking into account the context, the definition and characterization of marketing management, in order to determine the decisive and success factors for the companies, constitutes the contribution Theoretical to argue the research carried out. An exploratory investigation was conducted for consumers of mass products between 20 and 54 years of Santa Elena province and interviews were conducted with three distributors of mass consumer products. The results recommend that with the application of assertive marketing strategies based on the preferences of the target group, and market trends, organizational performance would be improved by attracting prospects and generating loyalty ties of current clients.
Las reformas al impuesto al valor agregado y su efecto en la economía del consumidor en la provincia de Santa Elena. Año 2016
Authors: Asencio Cristóbal Nelson , Panchana Margarita , Tomalá Mónica , Asencio Cristóbal Luis 
Published: June 2017

El objetivo del presente reporte es elaborar un análisis de las reformas tributarias del IVA implementadas en el país en el año 2016 y referir su impacto en la economía del consumidor en la provincia de Santa Elena. Desde una perspectiva teórica, se define la estructura impositiva del país y su importancia en la generación de ingresos públicos para la consecución objetivos sociales; así como también los fines que conllevan las reformas tributarias tendientes a regular la economía, fomentar el empleo, incentivar la producción, la demanda y el consumo. En la investigación que dio origen a este artículo se aplicaron procedimientos metodológicos deductivo, cuantitativo, y documental provenientes de fuentes oficiales y técnicas de investigación que permitieron obtener información relevante para el análisis descriptivo de las reformas, cuyos resultados reflejan la necesidad de que el gobierno, previa a la adopción de estas medidas, realice con profundidad un estudio socio-económico, que permita valorar las incidencias que tendrían en el sector productivo del país y en el consumido específicamente. En la investigación se describen las últimas reformas tributarias del IVA para luego referir su efecto general en el consumo de bienes y servicios del consumidor peninsular. AbstractThe objective of the present report is to develop an analysis of VAT tax reforms implemented in the country in the year 2016 and see its impact on the economy of the consumer in the province of Santa Elena. From a theoretical perspective, defines the country's tax structure and its importance in the generation of revenue to achieve social objectives; as well as also the purposes involving tax reforms aimed at regulating the economy, promoting employment, encourage the production, demand and consumption. In the research that gave origin to this article is applied procedures methodological deductive, quantitative, and documentary from of sources official and technical of research that allowed obtain information relevant to the analysis descriptive of them reforms, whose results reflect the need of the Government, prior to the adoption of these measures perform with depth a study partner-economic, that allow rating them incidents that would have in the sector productive of the country and in the consumed specifically. In the research is described the latest reforms tax of the VAT to then refer its effect general in the consumption of goods and services of the consumer peninsular.
Patients’ attitudes and perceptions towards treatment of hypothyroidism in general practice: an in-depth qualitative interview study
Authors: Dew Rosie , King Kathryn , Okosieme Onyebuchi E , Pearce Simon , Donovan Gemma , Taylor Peter , Leese Graham , Hickey Janis , Razvi Salman , Dayan Colin , Wilkes Scott 
Published: June 2017

BackgroundSuboptimal thyroid hormone replacement is common in patients with hypothyroidism and the behavioural factors underlying this are poorly understood.AimTo explore the attitudes and perceptions of patients to thyroid hormone replacement therapy.Design & settingAn in-depth qualitative interview study with patients with hypothyroidism residing in Northumberland, and Tyne and Wear, UK.MethodTwenty-seven patients participated, of which 15 patients had thyroid stimulating hormone (TSH) levels within the reference range (0.4–4.0 mU/L) and 12 patients had TSH levels outside the reference range. A grounded theory approach was used to explore and develop emerging themes, which were mapped to the health belief model (HBM).ResultsPatients generally had a low understanding of their condition or of the consequences of suboptimal thyroid hormone replacement. Patients that had experienced hypothyroid symptoms at initial diagnosis had a better perception of disease susceptibility, and this was reflected in excellent adherence to levothyroxine in this group of patients. The main benefits of optimal thyroid replacement were improved wellbeing and performance. However, patients who remained unwell despite a normal serum TSH level felt that their normal result presented a barrier to further evaluation of their symptoms by their GP.ConclusionEducating patients with hypothyroidism regarding the consequences of inadequate thyroid hormone replacement may reduce barriers and improve treatment outcomes. An over-reliance on TSH as a sole marker of wellbeing reduced opportunities for clinicians to address patient symptoms. Evaluating symptoms in combination with biochemical indices, may lead to better patient outcomes than relying on laboratory tests alone.
Identification of PAH Isomeric Structure in Cosmic Dust Analogs: The AROMA Setup
Authors: Sabbah Hassan , Bonnamy Anthony , Papanastasiou Dimitris , Cernicharo Jose , Martín-Gago Jose-Angel , Joblin Christine 
Published: June 2017

Abstract
We developed a new analytical experimental setup called AROMA (Astrochemistry Research of Organics with Molecular Analyzer) that combines laser desorption/ionization techniques with ion trap mass spectrometry. We report here on the ability of the apparatus to detect aromatic species in complex materials of astrophysical interest and characterize their structures. A limit of detection of 100 femto-grams has been achieved using pure polycyclic aromatic hydrocarbon (PAH) samples, which corresponds to 2 × 108 molecules in the case of coronene (C24H12). We detected the PAH distribution in the Murchison meteorite, which is made of a complex mixture of extraterrestrial organic compounds. In addition, collision induced dissociation experiments were performed on selected species detected in Murchison, which led to the first firm identification of pyrene and its methylated derivatives in this sample.
Pierres, mortiers et parements de la tour des Minimes au regard du compte de construction de 1495-1496, des investigations archéologiques et des analyses pétrographiques
Authors: Gaugain Lucie , Bréheret Jean-Gabriel , Mechling Jean-Michel , Prigent Daniel 
Published: June 2017

Le chantier de Charles VIII (1483-1498) au château
d’Amboise se déroula entre 1492 et 1498. L’année 1495-1496 est
documentée par un livre de compte concernant notamment la tour
cavalière des Minimes, aujourd’hui bien conservée. L’étude croisée du
bâti, du livre de compte, des pierres de taille (pétrographie et
statistique), des mortiers (granulométrie et analyses de la chaux) et
du badigeon recouvrant les joints a nécessité la mise en place d’une
méthodologie précise, demandant de continuels échanges entre
historiens de l’architecture, géologues et archéologues. Ces
investigations permettent d’identifier les dénominations des pierres
et le vocabulaire technique en usage à la fin du Moyen Âge. Mais bien
au-delà, elles démontrent l’intervention probable d’un appareilleur,
l’organisation du chantier régi en plusieurs pôles et ateliers, ainsi
que son rythme très soutenu puisque, pour la seule tour, plus de 15 m
de maçonneries voûtées furent élevées. Ce fut possible grâce à la
connaissance empirique des matériaux qu’avaient les hommes œuvrant à
la construction, à la qualité des matériaux employés et à la
remarquable mise en œuvre qui en fut faite. Il en résulte un ouvrage
hors du commun, d’une rare audace où quatre révolutions et demie de
voûtes d’ogives montent autour d’un noyau creux.
La construction de l'enseignement secondaire (1802-1914)
Authors: Savoie Philippe 
Published: June 2017

Cet ouvrage constitue la première histoire d'ensemble de l'enseignement secondaire au XIXe siècle. Il s’agit d’un magnifique outil de travail qui s’est attaché à retrouver la réalité des établissements en exploitant les rapports envoyés au ministère et les statistiques exceptionnellement riches du XIXe siècle. Ils permettent d’apprécier les effectifs d’élèves dans leur diversité de classe et de statut comme le fonctionnement pédagogique des « maisons ». L’histoire retracée s’articule autour de deux évolutions solidaires, l’une institutionnelle, l’autre pédagogique. Elle éclaire d’un jour nouveau bien des aspects actuels de notre enseignement. En analysant le passé, l’ouvrage explique le présent. C’est pourquoi il ne s’intéresse pas seulement aux historiens mais aussi aux actuels responsables et réformateurs de notre système éducatif.
Treatment of Low-Blast Count AML using Hypomethylating Agents
Authors: De Bellis Eleonora , Fianchi Luana , Buccisano Francesco , Criscuolo Marianna , Maurillo Luca , Cicconi Laura , Brescini Mattia , Del Principe Maria Ilaria , Di Veroli Ambra , Venditti Adriano , Lo-Coco Francesco , Voso Maria Teresa 
Published: June 2017

In 2002, the WHO classification reduced the proportion of blasts in the bone marrow (BM) necessary for the diagnosis of acute myeloid leukemia (AML) from 30% to 20%, eliminating the RAEB-t subtype of myelodysplastic syndromes (MDS). However, this AML subtype, defined as low-blast count AML (LBC-AML, with 20-30% BM-blasts) is characterized by peculiar features, as increased frequency in elderly individuals and after cytotoxic treatment for a different primary disease (therapy-related), poor-risk cytogenetics, lower white blood cell counts, and less frequent mutations of NPM1 and FLT3 genes. The clinical course of this entity is often similar to MDS with 10-19% BM-blasts. The hypomethylating agents azacitidine and decitabine have been shown to induce responses and prolong survival both in MDS and LBC-AML. The role of these agents has been also demonstrated in AML with >30% BM-blasts, particularly in patients with poor-risk cytogenetics and in AML with myelodysplasia related changes. Most recent studies are evaluating strategies to improve outcome, including combinations of hypomethylating agents with immune-response checkpoint inhibitors, which have a role in cancer immune surveillance. Efforts are also ongoing to identify mutations which may predict response and survival in these patients.
Foreign capital inflow and its welfare implications in a developing country context
Authors: Mukherjee Rudrarup 
Published: June 2017

Abstract
In a small open developing country context, the author considers a three-sector general equilibrium framework and tries to find out the effects of foreign capital inflow on welfare of the country. Comparative-static results show that foreign capital inflow widens the skilledunskilled wage gap under some reasonable conditions, although it causes an expansion of the foreign enclave and the agricultural sector and contraction of the domestic manufacturing sector. Taking sector specific foreign capital, the authors find that foreign direct investment is beneficial in a free market small open economy in the absence of tariff.
El desafío de la igualdad domestica a la apertura de las fronteras: el argumento de la singularidad de la coacción estatal | The challenge of domestic equality to the opening of borders: the argument of the singularity of state coercion
Authors: Arcos Ramírez Federico 
Published: June 2017

Resumen: Este trabajo examina uno de los argumentos más relevantes empleado para justificar que los integrantes de una misma comunidad política se deban mutuamente deberes de justicia distributiva más exigentes y fuertes que lo que tienen respecto al resto de seres humanos, hasta el punto de justificar un sistema de fronteras cerradas similar al actual. Se trata del que cabría denominar como “argumento de la singularidad de la coacción estatal”. El mismo asume como premisa empírica que dicha coacción es estructural y funcionalmente diferente a la que podamos encontrar en el ámbito internacional, incluida la que se ejerce a través de la prevención y represión directa de la entrada de personas a una determinada comunidad política por medio de los controles fronterizos. Abstract: The purpose of this paper is to examine one of the most relevant arguments among those used to justify that the members of the same political community owe each other more demanding and strong distribu- tive justice duties than they have with respect to other human beings, to the point of justify a system of closed borders similar to the current one. It is the one that could be denominated like "argument of the singularity of the state coercion". It assumes as an empirical premise that such coercion is structurally and functionally different from what we can find in the international arena, including that which is exercised through the direct prevention and repression of the entry of persons into a given political community by means of border controls.
Presupuestos hermenéuticos de la teoría comunicacional del derecho de Gregorio Robles | Hermeneutical Assumptions of Gregorio Robles’s Communicational Theory of Law
Authors: Santos Arnaiz José Antonio 
Published: June 2017

Resumen: El presente trabajo se centra en los presupuestos hermenéuticos de los que parte la teoría comunicacional del derecho de Gregorio Robles, como doctrina que muestra una vía de superación de la dicotomía entre filosofía analítica y hermenéutica con la finalidad de hacer más claro el lenguaje de los juristas. Para ello, se analizan cuatro de las obras del autor, desde un punto de vista descriptivo y crítico, que presentan una mayor impronta hermenéutica como son Introducción a la Teoría del Derecho, El Derecho como texto, Teoría del Derecho y Comunicación, lenguaje y derecho, para abordar el contexto en el que se mueve, sus influencias, la plausibilidad de la propia teoría dentro del marco analítico-hermenéutico, y el análisis descriptivo y crítico del manejo de determinados conceptos del debate hermenéutico en la teoría comunicacional del derecho. Abstract: The present paper focuses on the hermeneutical assumptions of Gregorio Robles’s communicational theory of law, as doctrine that shows a way of overcoming the dichotomy between analytical philosophy and hermeneutics in order to clarify the language of jurists. For that purpose, it analyzes four of the author’s works from a descriptive and critical point of view that present a greater hermeneutical influence such as Introduction to Legal Theory, Law as Text, Legal Theory and Communication, Language and Law, to tackle the context of the author, his influences, the plausibility of the theory itself within the analytical and hermeneutical framework, and the descriptive and critical analysis of the use of certain concepts of the hermeneutical debate in the communicational theory of law.
Shared Decision Making and Autonomy Among US Participants with Multiple Sclerosis in the NARCOMS Registry
Authors: Cofield Stacey S. , Thomas Nina , Tyry Tuula , Fox Robert J. , Salter Amber 
Published: June 2017

Background:
Treatment decisions in multiple sclerosis (MS) are affected by many factors and are made by the patient, doctor, or both. With new disease-modifying therapies (DMTs) emerging, the complexity surrounding treatment decisions is increasing, further emphasizing the importance of understanding decision-making preferences.

Methods:
North American Research Committee on Multiple Sclerosis (NARCOMS) Registry participants completed the Fall 2014 Update survey, which included the Control Preferences Scale (CPS). The CPS consists of five images showing different patient/doctor roles in treatment decision making. The images were collapsed to three categories: patient-centered, shared, and physician-centered decision-making preferences. Associations between decision-making preferences and demographic and clinical factors were evaluated using multivariable logistic regression.

Results:
Of 7009 participants, 79.3% were women and 93.5% were white (mean [SD] age, 57.6 [10.3] years); 56.7% reported a history of relapses. Patient-centered decision making was most commonly preferred by participants (47.9%), followed by shared decision making (SDM; 42.8%). SDM preference was higher for women and those taking DMTs and increased with age and disease duration (all P &lt; .05). Patient-centered decisions were most common for respondents not taking a DMT at the time of the survey and were preferred by those who had no DMT history compared with those who had previously taken a DMT (P &lt; .0001). There was no difference in SDM preference by current MS disease course after adjusting for other disease-related factors.

Conclusions:
Responders reported most commonly considering their doctor's opinion before making a treatment decision and making decisions jointly with their doctor. DMT use, gender, and age were associated with decision-making preference.
In-silicoprediction and modeling of theEntamoeba histolyticaproteins: Serine-richEntamoeba histolyticaprotein and 29 kDa Cysteine-rich protease
Authors: Manochitra Kumar , Parija Subhash Chandra 
Published: June 2017

BackgroundAmoebiasis is the third most common parasitic cause of morbidity and mortality, particularly in countries with poor hygienic settings. There exists an ambiguity in the diagnosis of amoebiasis, and hence there arises a necessity for a better diagnostic approach. Serine-richEntamoeba histolyticaprotein (SREHP), peroxiredoxin and Gal/GalNAc lectin are pivotal inE. histolyticavirulence and are extensively studied as diagnostic and vaccine targets. For elucidating the cellular function of these proteins, details regarding their respective quaternary structures are essential. However, studies in this aspect are scant. Hence, this study was carried out to predict the structure of these target proteins and characterize them structurally as well as functionally using appropriatein-silicomethods.MethodsThe amino acid sequences of the proteins were retrieved from National Centre for Biotechnology Information database and aligned using ClustalW. Bioinformatic tools were employed in the secondary structure and tertiary structure prediction. The predicted structure was validated, and final refinement was carried out.ResultsThe protein structures predicted by i-TASSER were found to be more accurate than Phyre2 based on the validation using SAVES server. The prediction suggests SREHP to be an extracellular protein, peroxiredoxin a peripheral membrane protein while Gal/GalNAc lectin was found to be a cell-wall protein. Signal peptides were found in the amino-acid sequences of SREHP and Gal/GalNAc lectin, whereas they were not present in the peroxiredoxin sequence. Gal/GalNAc lectin showed better antigenicity than the other two proteins studied. All the three proteins exhibited similarity in their structures and were mostly composed of loops.DiscussionThe structures of SREHP and peroxiredoxin were predicted successfully, while the structure of Gal/GalNAc lectin could not be predicted as it was a complex protein composed of sub-units. Also, this protein showed less similarity with the available structural homologs. The quaternary structures of SREHP and peroxiredoxin predicted from this study would provide better structural and functional insights into these proteins and may aid in development of newer diagnostic assays or enhancement of the available treatment modalities.