bluuebunny/crossref_metadata_2025_split huggingface dataset:
Winner of the society for biomaterials young investigator award for the annual meeting of the society for biomaterials, April 11–14, 2018, Atlanta, GA: S‐nitrosated poly(propylene sulfide) nanoparticles for enhanced nitric oxide delivery to lymphatic tissues
Authors: Schudel Alex , Sestito Lauren F. , Thomas Susan N. 
Published: January 2018

AbstractNitric oxide (NO) is a therapeutic implicated for the treatment of diseases afflicting lymphatic tissues, which range from infectious and cardiovascular diseases to cancer. Existing technologies available for NO therapy, however, provide poor bioactivity within lymphatic tissues. In this work, we address this technology gap with a NO encapsulation and delivery strategy leveraging the formation of S‐nitrosothiols on lymphatic‐targeting pluronic‐stabilized, poly(propylene sulfide)‐core nanoparticles (SNO‐NP). We evaluated in vivo the lymphatic versus systemic delivery of NO resulting from intradermal administration of SNO‐NP benchmarked against a commonly used, commercially available small molecule S‐nitrosothiol NO donor, examined signs of toxicity systemically as well as localized to the site of injection, and investigated SNO effects on lymphatic transport and NP uptake by lymph node (LN)‐resident cells. Donation of NO from SNO‐NP, which scaled in proportion to the total administered dose, enhanced LN accumulation by two orders of magnitude without substantially reducing lymphatic transport of NP or the viability and extent of NP uptake by LN‐resident cells. Additionally, NO delivery by SNO‐NP was accompanied by low‐to‐negligible NO accumulation in systemic tissues with no apparent inflammation. These results suggest the utility and selectivity of SNO‐NP for the targeted treatment of NO‐regulated diseases that afflict lymphatic tissues. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1463–1475, 2018.
Induced cumulus expansion of poor quality buffalo cumulus oocyte complexes by Interleukin‐1beta improves their developmental ability
Authors: Chaubey Gaurav Kumar , Kumar Sandeep , Kumar Manish , Sarwalia Parul , Kumaresan Arumugam , De Sachinandan , Kumar Rakesh , Datta Tirtha Kumar 
Published: January 2018

AbstractThe present study was conceived with the aim of modulating the cumulus expansion characteristics of poor quality (BCB−) buffalo oocyte complexes (COCs) in order to improve their fertilization outcomes. BCB− COCs were subjected to in vitro maturation (IVM) in presence of Interleukin‐1 beta (IL‐1β) along with BCB‐ (control) and good quality (BCB+) COCs. Results were assessed morphologically, by scanning electron microscopy (SEM) and by expression analysis of cumulus expansion related genes. Also, numbers of zona pellucida bound spermatozoa were counted and development rates of oocytes were monitored under different groups. Expression of versican isoforms and ADAMTS‐1 was observed to be significantly different between cumulus cells of BCB+ and BCB− COCs. Upon IL‐1β supplementation, ADAMTS‐1 expression increased in BCB− COCs along with corresponding cumulus expansion rates. SEM analysis also revealed improved cumulus expansion in IL‐1β supplemented BCB‐ COCs. HAS2 and TNFAIP‐6 were significantly up‐regulated after IL‐1β supplementation while PTGS2 expression remained unaffected. Significantly more numbers of sperms crossed the cumulus barrier, especially in 100 ng/mL IL‐1β supplemented COCs. Besides, cleavage and blastocyst development rates were also improved upon IL‐1β addition. We concluded that IL‐1β supplementation in IVM medium can improve cumulus expansion and development ability of poor quality buffalo oocytes.
Localization of palmitoylated and activated G protein α‐subunit in Dictyostelium discoideum
Authors: Alamer Sarah , Kageyama Yusuke , Gundersen Robert E. 
Published: January 2018

AbstractGuanine nucleotide‐binding proteins (G proteins) act as molecular switches to regulate many fundamental cellular processes. The lipid modification, palmitoylation, can be considered as a key factor for proper G protein function and plasma membrane localization. In Dictyostelium discoidum, Gα2 is essential for the chemotactic response to cAMP in their developmental life cycle. However, the regulation of Gα2 with respect to palmitoylation, activation and Gβγ association is less clear. In this study, Gα2 is shown to be palmitoylated on Cys‐4 by [3H]palmitate labeling. Loss of this palmitoylation site results in redistribution of Gα2 within the cell and poor D. discoideum development. Cellular re‐localization is also observed for activated Gα2. In the membrane fraction, Gα2‐wt (YFP) is highly enriched in a low‐density membrane fraction, which is palmitoylation‐dependent. Activated Gα2 monomer and heterotrimer are shifted to two different higher‐density fractions. These results broaden our understanding of how G protein localization and function are regulated inside the cells.
Empirically derived lifespan polytraumatization typologies: A systematic review
Authors: Contractor Ateka A. , Caldas Stephanie , Fletcher Shelley , Shea M. Tracie , Armour Cherie 
Published: January 2018

AbstractContextPolytraumatization classes based on trauma endorsement patterns relate to distinct clinical outcomes. Person‐centered approaches robustly evaluate the nature, and construct validity of polytraumatization classes.ObjectiveOur review examined evidence for the nature and construct validity of lifespan polytraumatization typologies.Data sourcesIn September 2016, we searched Pubmed, PSYCINFO, PSYC ARTICLES, Academic Search Complete, PILPTS, Web of Science, CINAHL, Medline, PsycEXTRA, and PBSC. Search terms included “latent profile,” “latent class,” “latent analysis,” “person‐centered,” “polytrauma,” “polyvictimization,” “traumatization,” “lifetime,” “cooccurring,” “complex,” “typology,” “multidimensional,” “sequential,” “multiple,” “subtype,” “(re)victimization,” “cumulative,” “maltreatment,” “abuse,” and “stressor.” Inclusionary criteria included: peer‐reviewed; latent class/latent profile analyses (LCA/LPA) of lifespan polytrauma classes; adult samples of size greater than 200; only trauma types as LCA/LPA indicators; mental health correlates of typologies; and individual‐level trauma assessment. Of 1,397 articles, nine met inclusion criteria.Data extractionFollowing Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, research assistants completed a secondary reference search, and independently extracted data with standardized coding forms.ResultsThree‐class (n = 5) or four‐class (n = 4) solutions were found. Seven studies found a class characterized by higher trauma endorsement (high‐trauma). All studies found a class characterized by lower trauma endorsement (low‐trauma), and predominance of specific traumas (specific‐trauma; e.g., childhood maltreatment). High‐trauma versus low‐trauma classes and specific‐trauma versus low‐trauma classes differed on mental health correlates.ConclusionEvidence supports the prevalence of a high‐trauma class experiencing poorer mental health, and the detrimental impact of aggregated interpersonal and other traumas. We highlight the clinical importance of addressing polytraumatization classes, and comprehensively assessing the impact of all traumas.
Heavy gas oil biodesulfurization using a low‐cost bacterial consortium
Authors: Porto Bruna , Maass Danielle , Oliveira José V , de Oliveira Débora , Yamamoto Carlos Itsuo , Ulson de Souza Antônio A , Ulson de Souza Selene M A Guelli 
Published: January 2018

AbstractBACKGROUNDPetroleum and its derivatives usually contain large amounts of sulfur. During the combustion of fossil fuels, sulfur is liberated to the atmosphere in the form of one of the most noxious pollutants: sulfur dioxide (SOx). The removal of sulfur content to the ultralow levels demanded by worldwide legislation has been a challenge to the refinery industry, principally due to the inefficiency of conventional processes, such as hydrodesulfurization, which are not capable of removing the recalcitrant sulfur compounds. Biodesulfurization is a biological process that removes these sulfur compound pollutants from hydrocarbons. However, there are several unsolved technological difficulties associated with this procedure, including the development of a stable and efficient biocatalyst, and a low‐cost culture medium. Thus, the use of a bacterial consortium (BC) as a substitute for both biocatalyst and nutritional medium was studied in order to improve the biodesulfurization process.RESULTSThe desulfurization activity was determined at different temperatures and BC concentrations. An efficient desulfurization capacity (71.2%) was observed using only 5% (w/w) of BC at 45 °C. At this temperature, the total time required for biodesulfurization was substantially reduced; only 2 h was required to achieve the highest desulfurization capacity.CONCLUSIONThe BC can be used as a substitute for biocatalysts and nutritional media for heavy gas oil desulfurization. Desulfurization capacity using the BC was similar to that achieved using other pure bacterial strains and culture media, and the process time was diminished. BC use represents an important improvement in biodesulfurization technology. © 2018 Society of Chemical Industry
NIR‐responsive nanomaterials and their applications; upconversion nanoparticles and carbon dots: a perspective
Authors: Chien Yi‐Hsin , Chan Kok Ken , Yap Stephanie Hui Kit , Yong Ken‐Tye 
Published: January 2018

AbstractNear‐infrared (NIR) light responsive materials have received much attention for diverse applications due to their excellent optical properties. This type of material exhibits upconverted luminescence, a non‐linear optical process in which two or more low energy photons, usually from NIR light irradiation are transformed to high energy photons emission through energy transfer upconversion, excited state absorption, photon avalanche or multiphoton absorption. The NIR range of excitation source is favorable for biological imaging and cancer theranostic applications due to their high penetration depth, low autofluorescence, minimal light scattering, reduced photodamage, and negligible phototoxicity. Having these properties, NIR responsive materials such as upconversion nanoparticles (UCNPs) and carbon dots (CDs) which perform upconversion luminescence are actively exploited in a wide variety of applications such as display and sensory technology. While CDs are well known for their versatility in using different chemicals and green precursors to achieve tunable optical properties, UCNPs also have the advantage that a continuous‐wave NIR laser can be used as the excitation source. This article reviews the properties of these two materials in the aspects of luminescence mechanisms and their recent developments in cancer theranostics, display technology, biosensing and metal ions sensing applications. © 2018 Society of Chemical Industry
Nonlinear response of precipitation to climate indices using a non‐stationary Poisson‐generalized Pareto model: case study of southeastern Canada
Authors: Thiombiano Alida N. , St‐Hilaire André , El Adlouni Salah‐Eddine , Ouarda Taha B. M. J. 
Published: January 2018

ABSTRACTQuantile estimates are generally interpreted in association with the return period concept in practical engineering. To do so with the peaks‐over‐threshold (POT) approach, combined Poisson‐generalized Pareto distributions (referred to as PD‐GPD model) must be considered. In this article, we evaluate the incorporation of non‐stationarity in the generalized Pareto distribution (GPD) and the Poisson distribution (PD) using, respectively, the smoothing‐based B‐spline functions and the logarithmic link function. Two models are proposed, a stationary PD combined to a non‐stationary GPD (referred to as PD0‐GPD1) and a combined non‐stationary PD and GPD (referred to as PD1‐GPD1). The teleconnections between hydro‐climatological variables and a number of large‐scale climate patterns allow using these climate indices as covariates in the development of non‐stationary extreme value models. The case study is made with daily precipitation amount time series from southeastern Canada and two climatic covariates, the Arctic Oscillation (AO) and the Pacific North American (PNA) indices. A comparison of PD0‐GPD1 and PD1‐GPD1 models showed that the incorporation of non‐stationarity in both POT models instead of solely in the GPD has an effect on the estimated quantiles. The use of the B‐spline function as link function between the GPD parameters and the considered climatic covariates provided flexible non‐stationary PD‐GPD models. Indeed, linear and nonlinear conditional quantiles are observed at various stations in the case study, opening an interesting perspective for further research on the physical mechanism behind these simple and complex interactions.
The impacts of the Indonesian Throughflow on the inter‐basin seesaw mechanism, in idealized experiments
Authors: Santis Wlademir , Aímola Luis , Castellanos Paola , Campos Edmo J. D. 
Published: January 2018

ABSTRACTThe role that the Indonesian Throughflow plays on climate is investigated in an alternative scenario, expected during glacial ages. The equatorwards shift of the Southern Hemisphere westerlies found in glacial ages acts to decrease the Agulhas Leakage (AL) and the thermohaline circulation (THC) in the Atlantic. Recent results suggest that these changes are followed by an increased THC in the Pacific, through an inter‐basin seesaw mechanism. The enhanced circulation in the Pacific demands thermocline water to cross the equator towards northern latitudes, which shifts the water source of the throughflow from the low‐salinity North Pacific to the relative saltier South Pacific. It is shown that in this equilibrium, the salinity anomalies of the throughflow impact the inter‐basin seesaw towards the restoration of the modern climate, enhancing the North Atlantic Deep Water (NADW) formation and decreasing the THC in the Pacific. These results are consistent with paleo‐observations and provide new insights to interpreting the climate changes in glacial periods.
Differential proteomic analysis of synovial fluid from hip arthroplasty patients with a pseudotumor vs. Periprosthetic osteolysis
Authors: Catelas Isabelle , Lehoux Eric A. , Ning Zhibin , Figeys Daniel , Baskey Stephen J. , Beaulé Paul E. 
Published: January 2018

ABSTRACTAdverse tissue reactions to metal implants, including pseudotumors, can compromise implant functionality and survivorship. The identification of specific proteins in the synovial fluid (SF) of hip arthroplasty patients with a pseudotumor may lead to a better understanding of the underlying pathomechanisms. The objective of the present study was to compare the protein content of SF from patients with a short‐term metal‐on‐metal hip implant associated with a pseudotumor and patients with a long‐term metal‐on‐polyethylene hip implant associated with periprosthetic osteolysis. Discovery proteomics was used to identify differentially abundant proteins in albumin‐depleted SF. In toto, 452 distinct proteins (present in at least half of the patients in one or both groups) were identified. Thirty of these 452 proteins were differentially abundant between the two groups, including two potential biomarkers: 6‐phosphogluconate dehydrogenase (which plays a major protective role against oxidative stress) for the pseudotumor group, and scavenger receptor cysteine‐rich type 1 protein M130 (which is involved in low‐grade inflammation) for the periprosthetic osteolysis group. Other differentially abundant proteins identified suggest the presence of an adaptive immune response (particularly a type‐IV hypersensitivity reaction), necrosis, and greater oxidative stress in patients with a pseudotumor. They also suggest the presence of an innate immune response, oxidative stress, tissue remodeling, and apoptosis in both patient groups, although differences in the specific proteins identified in each group point to differences in the pathomechanisms. Overall, results provide insights into the molecular mechanisms underlying metal‐related pseudotumors and periprosthetic osteolysis, and may ultimately help elucidate pseudotumor etiology and assess the risk that asymptomatic pseudotumors will develop into an aggressive lesion. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1849–1859, 2018.
Characteristics of proanthocyanidins in leaves of Chamaecyparis obtusa var. formosana as strong α‐glucosidase inhibitors
Authors: Hsu Chia‐Yun , Lin Gong‐Min , Lin Huan‐You , Chang Shang‐Tzen 
Published: January 2018

AbstractBACKGROUNDIn recent decades, there has been a growing demand for natural products with a view to using them as α‐glucosidase inhibitors for reducing postprandial hyperglycemia. In this study, the hot water extract (HWE) from Chamaecyparis obtusa var. formosana (Hayata) Rehder (Cupressaceae) leaves and its soluble fractions were screened for α‐glucosidase inhibition properties. The n‐butanol‐soluble fraction of HWE was further fractionated into 14 subfractions (B1–B14) using a Sephadex LH‐20 column. The α‐glucosidase‐inhibitory activities and proanthocyanidin contents of all subfractions were determined. The structural characteristics of proanthocyanidins in proanthocyanidin‐rich fractions were also elucidated.RESULTSHWE produced a dose‐dependent inhibition of α‐glucosidase at low dose. Its IC50 value was 1.4 µg mL−1, showing high inhibitory activity. Subfractions B7–B14 displayed powerful α‐glucosidase‐inhibitory activities with IC50 values ranging between 1 and 0.015 µg mL−1 and contained abundant proanthocyanidins exceeding 300 mg g−1. The proanthocyanidins with higher mean degree of polymerization (mDP), higher proportions of procyanidin dimer (A1 or A2) and (epi)afzelechin of extension units and a lower proportion of epicatechin of terminal units displayed high α‐glucosidase‐inhibitory activities.CONCLUSIONProanthocyanidins in HWE were viewed as potential natural α‐glucosidase inhibitors for decreasing postprandial hyperglycemia. The results indicated that specific structural characteristics of proanthocyanidins would be required for α‐glucosidase‐inhibitory activity. © 2018 Society of Chemical Industry
Effect of methyl salicylate in combination with 1‐methylcyclopropene on postharvest quality and decay caused by Botrytis cinerea in tomato fruit
Authors: Min Dedong , Li Fujun , Zhang Xinhua , Shu Pan , Cui Xixi , Dong Lulu , Ren Chuntao , Meng Demei , Li Jian 
Published: January 2018

AbstractBACKGROUNDPostharvest diseases result in major losses in fruits. Tomato is susceptible to postharvest rot caused by Botrytis cinerea and is regarded as a good model system to study postharvest disease and quality deterioration in fruit. To develop a safe and effective technique to alleviate disease and maintain fruit quality, the effects of methyl salicylate (MeSA) and 1‐methylcyclopropene (1‐MCP) either separately or combined on quality and gray mold caused by B. cinerea in tomato fruit were investigated.RESULTSThe results showed that application of MeSA (0.05 mmol L−1) delayed fruit ripening and reduced gray mold. Compared with MeSA treatment, 1‐MCP (0.5 µL L−1) effectively delayed fruit ripening. Further, MeSA combined with 1‐MCP treatment was more effective in inhibiting fungal decay during storage than MeSA treatment alone. The combined treatment not only enhanced pathogenesis‐related protein 1 (PR1) expression, activities of defense enzymes and total phenolic content but also inhibited the increase in electrical conductivity and malondialdehyde content. The combined treatment was also more effective in retaining firmness, color change and titratable acidity content than MeSA treatment alone.CONCLUSIONMeSA combined with 1‐MCP treatment was a useful technique to maintain quality and alleviate gray mold in postharvest tomato fruit during storage. © 2018 Society of Chemical Industry
A laser optical method for predicting adulteration of clover honey
Authors: El‐Raie Ahmed Emam , Hassan Helmy Elsayed , Abdel‐Raouf Abdel‐Rahman , Rabea Shaimaa 
Published: January 2018

AbstractBACKGROUNDThe authenticity of honey is of great importance for commercial and health reasons, because adulteration of bee honey with cheaper sweetening materials is sometimes carried out for financial gain. The objectives of this study were to evaluate clover honey quality according to physicochemical characteristics, to measure light transmission through honey samples using a visible laser technique (He–Ne laser at 632.8 nm) and to predict types of adulterants of clover honey according to the transmission intensity of the laser beam through the sample.RESULTSThe transmission intensity of pure clover honey was 3520 lx. Addition of water or sugar solution at various concentrations led to increased transmission intensities in the range 4720–6980 lx, while addition of glucose honey led to increased transmission intensities in the range 3570–4120 lx. However, addition of starch suspension or black honey led to decreased transmission intensities in the ranges 3440–120 and 2770–85 lx respectively. The physicochemical properties of pure clover honey were within the standard limits. The light microscope image of pollen in the honey indicated that the pollen came from the clover plant.CONCLUSIONThe transmission intensity method using visible laser light to predict the type of adulteration of clover honey can be considered a fast and accurate method. © 2018 Society of Chemical Industry
From lesser‐known to super vegetables: the growing profile of African traditional leafy vegetables in promoting food security and wellness
Authors: Aworh Ogugua C 
Published: January 2018

AbstractThere are hundreds of traditional leafy vegetables and wild food plants of horticultural and nutritional significance in Africa. These lesser‐known crops and wild food plants that are highly adapted to harsh growing conditions thrive with little care and are available when other sources of food fail or are out of season. They are rich in micronutrients and are often the cheapest sources of many essential vitamins and minerals in many localities. Many of them are very important functional foods in African traditional diets and are rich in nutraceuticals, including polyphenols, tannins, flavonoids and flavonols, that exert demonstrable antioxidant, free radical scavenging and enzyme inhibition activities and have antimicrobial properties that provide scientific justification and possible mechanisms for their use in the management of a wide range of ailments, including diet‐related, non‐communicable diseases such as diabetes, hypertension and cardiovascular diseases. African traditional leafy vegetables are invaluable in promoting food security and wellness in Africa on account of their availability and affordability, their great nutritional value, chemotherapeutic and health‐promoting properties and other unique qualities. Long recognised by the rural populace as quality food items, they are becoming more popular even with the more affluent urban elites. There is the need to develop improved management practices for these super vegetables to promote their cultivation and boost their exploitation for food security and wellness in Africa. © 2018 Society of Chemical Industry