bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the Claim that Islam Frightens People with Eternal Pain
Authors: Saruhan Müfit Selim 
Published: September 2024

There are various prejudices in society regarding the Islamic concepts of faith. These prejudices are easily eliminated when faced with true knowledge and basic religious sources. Allegations often represent uninformed judgment. The main goal of this article is to clarify a frequently asked question about Islamic beliefs regarding the afterlife. According to some, this question has recently caused young people to break away from faith. To what extent can we embrace a religion that predicts eternal torment? In this article, we draw attention to these prejudices and encourage readers to investigate the intellectual depth of Islam based on knowledge. Humans have great potential. However, a person can achieve happiness in both the world and the hereafter by revealing the potential given to him from birth through his/her choices and behaviors. A person can reveal his existing talent in the best and most accurate way by reflecting on the meanings of the names of his Lord, who created him, in his life and living in accordance with them. Prejudices regarding Islamic religion’s understanding of the afterlife have come to the fore on social media and books. In this article, we discuss the claim about Islam that "it scares us with eternal torment.” Does Islam really scare people with punishments? Are people attached to Islam out of fear, as claimed? Does the Holy Quran suppress questioning? Or does this encourage it? It is possible to find many pros and consensuses in the history of commentary and theology regarding whether punishment is eternal. While evaluating these views, we must be responsible for ensuring and filtering whether they conform to the spirit and basic goals of the Holy Quran and Hadiths. The fact that the names of forgiving, merciful, and merciful are among the beautiful Names of Allah (Al-Asma Al-Husna), but the names of the one who punishes, the one who is angry, and the one who torments are excluded, should be accepted as evidence that the punishment will not be eternal. Mercy is an ancient attribute that cannot be separated from the essence of Allah.
TAKHRIJ AL-HADITH IN MU’JAM AL-KABIR: THE PROHIBITION OF OVEREATING IN ISLAM
Authors: Nasution Alhafidh , Nurdiana Evi , Rohmah Qonitatu Zulfatu 
Published: September 2024

<div class="WordSection1"><p>This research is motivated by the fact that many Muslims are not aware of the urgency of studying the science of hadith and its implementation in life. Therefore, this study aims to examine a hadith related to the prohibition of excessive eating in the book <em>Mu’jam al-Kabir </em>by Imam at-Thabrani as one of the efforts in implementing the science of hadith. This study also aims to provide understanding to the Muslim community to avoid diseases that harm health due to overeating. The result of this research is that in the book <em>Mu’jam al-Kabir, </em>it is explained that the Prophet Muhammad likened people who overeat to unbelievers who are less grateful for the favor of Allah. On the contrary, it is said that a grateful believer will understand how to be right with Allah and not make material things the purpose of his life. Therefore, it can be seen the difference in attitudes and views between Believers and Infidels in receiving Allah’s favor. Using the methodology of takhrij hadith, it can be concluded that the hadith has the degree of shahih, there is no <em>shadz, ‘illah, </em>or defects in the hadith. All narrators of hadith have the nature of <em>Thiqah </em>so that the hadith can be accepted.</p><p> </p><p>[</p><p>Penelitian ini dilatarbelakangi oleh banyaknya umat Muslim yang kurang sadar akan urgensi mempelajari ilmu hadis serta implementasinya dalam kehidupan. Oleh karena itu, tujuan penelitian ini adalah untuk mengkaji suatu hadis terkait larangan makan berlebihan dalam kitab <em>Mu’jam al-Kabir </em>karya Imam at-Thabrani sebagai salah satu upaya dalam implementasi ilmu hadis. Penelitian ini juga bertujuan untuk memberikan pemahaman kepada masyarakat Muslim agar terhindar dari penyakit yang merugikan kesehatan sebab makan berlebihan. Adapun hasil dari penelitian ini adalah dalam kitab <em>Mu’jam al- Kabir </em>dijelaskan bahwa Nabi Muhammad mengumpamakan orang yang makan berlebih layaknya orang kafir yang kurang bersyukur akan nikmat Allah. Sebaliknya, dikatakan bahwa orang Mukmin yang bersyukur akan mengerti bagaimana adab yang benar terhadap Allah dan tidak menjadikan materi sebagai tujuan dari hidupnya. Oleh karena itu, dapat dilihat perbedaan sikap dan pandangan antara orang Mukmin dan Kafir dalam menerima nikmat Allah. Dengan menggunakan metodologi takhrij hadis, dapat disimpulkan bahwa hadis tersebut memiliki derajat shahih, tidak ada <em>syadz, ‘illah</em>, maupun kecacatan dalam hadis. Serta keseluruhan perawi hadis memiliki sifat <em>Thiqah </em>sehingga hadis tersebut dapat diterima.]</p></div>
Effectiveness of Proprioceptive Neuromuscular Facilitation Pattern on Upper Extremity and Scapula in Patients with Adhesive Capsulitis: A single centre assessor-blinded Randomised controlled trial (RCT)
Authors: Khan Abid Hasan , Bhuiyan Md. Saruar Hossain , Kabir Md. Feroz , Hossain Md. Zahid , Jahan Sharmila , Hos Kazi Md. Amran , Rahman Ehsanur 
Published: September 2024

Abstract

Background
Adhesive capsulitis (AC) is a progressive inflammatory condition of the shoulder that causes functional limitations and leads to long-term disability. The study aimed to elicit the effectiveness of Proprioceptive neuromuscular facilitation (PNF) compared to standard physiotherapy approaches on AC.
Methods
An assessor-blinded single-centre Randomized control trial (RCT) was carried out on 80 AC patients between May and December 2023 in Bangladesh. Random assigned and concealed allocated patients were recruited equally (n = 40) to each PNF and conventional capsular stretching group. The experimental group received a PNF approach, and the control group received capsular stretching to the affected shoulder for 24 sessions in 6 weeks. Both groups received electrical modalities as standard treatment. The primary outcome was pain measured by the Numeric pain rating scale (NPRS) and range of motion in a universal goniometer. The secondary outcome was functional limitation measured by the Shoulder pain and disability index (SPADI). As per the distribution of data, non-parametric tests were employed to analyse the superiority between and within groups with intention-to-treat analysis.
Results
Baseline compatibility was noted in all the key variables (P > 0.05). Both PNF and capsular stretching had a decrease in pain compared to baseline in all capsular pattern positions (P < 0.001), and PNF had more significant improvement compared to control (P < 0.001). Both groups had equal improvement in shoulder ROM (P < 0.001) except abduction (P < 0.05). Both groups had improvements in disability (P < 0.05), and PNF had statistical superiority of improvement (P < 0.001).
Conclusions
The findings of this study support the potential of PNF intervention for 6 weeks as a treatment for shoulder Adhesive capsulitis, showing improvements in pain, ROM, and functional disability. However, further multicentre trials with a follow-up design are needed to fully understand the superiority of PNF on shoulder AC, encouraging continued engagement in this area of research.
Trial registration:
The Australian New Zealand Clinical Trial Registry (http://www.anzctr.org.au) (ACTRN12621001299897).
Ginsenosides mixture from Panax ginseng C.A.Meyer improves CoCl2-induced oxidative stress and mitochondrial dysfunction through NAD+-dependent SIRT1 activation in cardiomyocytes
Authors: Lou Tingting , Huang Qungxia , Zhao Daqing , Li Xiangyan 
Published: September 2024

Abstract

Introduction: There is growing recognition that medical therapies aimed at mediating mitochondrial ROS production may be important strategies to ameliorate cardiac disorders. Total ginsenosides (GS), a primary constituent extracted from Panax ginseng C.A.Meyer (ginseng) roots shows a strong therapeutic activity in heart disease and health benefits for hypoxia-related diseases. However, it is unclear whether GS protects hypoxic cardiomyocytes based on ROS production and mitochondrial function, as well as its molecular mechanism. Methods: In this study, mitochondrial respiratory function, ATP production, mitochondrial biosynthesis, glucose uptake, and NAD+-dependent SIRT1 activation in hypoxic and GS-pretreated H9c2 cells were investigated.
Results: We found that GS protected cells from oxidative damage and also maintained normal mitochondrial function in CoCl2-stimulated cardiomyocytes. GS significantly reduced the glucometabolism disorder and mitochondrial respiration dysfunction as well. Further studies confirmed GS increased mitochondrial contents through regulating the NAD+ dependent SIRT1 activation, which was completely abrogated by nicotinamide. Importantly, we found that the ginsenoside Rg1, Re, Rf, Rb1, Rc and Rb2 are the key substances in GS associated with the anti-hypoxic action.
Conclusion: This study may provide new insights into the protection of ginseng against cardiac hypoxia damage.
Causal relationship between plasma metabolites and chronic original pain: a Mendelian randomization study
Authors: Li Yanwen , Peng Kang , Li Yan , Zhang Wei , Guo Liling , Chen Long 
Published: September 2024

Abstract

Background
Chronic pain is an enormous economic and personal health burden worldwide, with more than one-third of the population suffering from chronic pain. However, no studies have systematically analyzed the potential role of plasma metabolites in chronic original pain.
Methods
Pooled genome-wide association study (GWAS) data for 1400 plasma metabolites from Brent Richards' research were used as exposures and genetic data from the UK Biobank related to 8 chronic regional pains were used as outcomes, including headache, facial pain, neck and shoulder pain, back pain, hip pain, abdominal pain, knee pain, and general pain. Causal associations between genetically predicted plasma metabolites and chronic regional pain were analyzed using the inverse variance weighting (IVW) method as the main tool for Mendelian randomization (MR) analyses, and horizontal pleiotropy tests and sensitivity analyses were performed for each pain phenotype by MR PRESSO and leave-one-out. In addition, four additional analyses were used to strengthen our findings, including weighted median, sample mode, weighted mode, and MR Egger. Finally, inverse MR analyses were performed to refine our results further.
Results
Significant evidence from MR analyses showed that 134 plasma metabolites associated with eight chronic pain conditions were screened for MR analysis, and a total of 140 associations showing evidence of causality were identified, with six metabolites acting in both pain conditions. Of these, 78 were identified as protective factors for chronic regional pain and 66 as risk factors. Notably, sensitivity analyses and heterogeneity tests strengthened the reliability of these results. The reverse MR analysis showed that neck-shoulder pain decreased the AMP to N-palmitoyl-sphingosine ratio.
Conclusions
The results of this research provide genetic proof for the study of chronic pain, revealing a latent genetic propensity between plasma metabolites and chronic pain, and identifying a role for plasma metabolites in different chronic pain phenotypes. These insights provide a framework for future clinical trials, suggesting that future research directions could focus on interventions related to plasma metabolites to treat or moderate chronic regional pain and its associated risk factors.
Modeling and Optimization Control of SOEC with Flexible Adjustment Capabilities
Authors: He Yaqing , Wang Weiqing , Chi Yingtian , Li Jiarong , Zhang Xinyan , Liu Bowen 
Published: September 2024

Abstract

Due to the random fluctuations in power experienced by high-temperature green electric hydrogen production systems, further deterioration of spatial distribution characteristics such as temperature, voltage/current, and material concentration inside the solid oxide electrolysis cell (SOEC) stack may occur. This has a negative impact on the system's flexibility and the corresponding control capabilities. In this paper, based on the SOEC electrolytic cell model, a comprehensive optimization method using an adaptive incremental Kriging surrogate model is proposed. The reliability of this method is verified by accurately analyzing the dynamic performance of the SOEC and the spatial characteristics of various physical quantities. Additionally, a thermal dynamic analysis is performed on the SOEC, and an adaptive time-varying LPV-MPC optimization control method is established to ensure the temperature stability of the electrolysis cell stack, aiming to maintain a stable, efficient, and sustainable SOEC operation. The simulation analysis of SOEC hydrogen production adopting a variable load operation has demonstrated the advantages of this method over conventional PID control in stabilizing the temperature of the stack. It allows for a rapid adjustment in the electrolysis voltage and current and improves electrolysis efficiency. The results highlighted that the increase in the electrolysis load increases the current density, while the water vapor, electrolysis voltage, and H2 flow rate significantly decrease. Finally, the SOEC electrolytic hydrogen production module is introduced for optimization scheduling of energy consumption in Xinjiang, China. The findings not only confirmed that the SOEC can transition to the current load operating point at each scheduling period but also demonstrated higher effectiveness in stabilizing the stack temperature and improving electrolysis efficiency.
Integrating a Microphysiological System and Physiologically Based Pharmacokinetic Modeling to Predict Human Responses to Diclofenac
Authors: Han Sungpil , Choi Suein , Lee Junghyun , Kim Okju , Ryu Taehoon , Kim Su Jung , Kim Eun Joo , Sung Jong Hwan , Cha Hwa Jun , Jung Yushin 
Published: September 2024

Abstract

Conventional two-dimensional in vitro cell cultures and animal models often inadequately predict human pharmacokinetics (PKs) and pharmacodynamics owing to the complexity of human physiology and interspecies diversity. This study introduces an innovative approach integrating a microphysiological systems (MPS) with physiologically based pharmacokinetic (PBPK) modeling and transcriptomic analysis to address these challenges. Our multiorgan MPS, incorporating gut, liver, and kidney chips, employs advanced microfluidic technology with cocultures of relevant human cell types to more accurately replicate the human physiological environment. Employing diclofenac, a widely used nonsteroidal anti-inflammatory drug, as a case study, we validated our model, demonstrating its accuracy in simulating human PK parameters. Integration of PBPK modeling with MPS results enhanced predictive precision. Furthermore, we incorporated transcriptomic analysis to investigate diclofenac’s mechanistic effects, revealing pathways potentially associated with its gastrointestinal toxicity and identifying differentially expressed genes linked to drug exposure and adverse effects. The integrated MPS with PBPK and transcriptomic approach holds substantial promise for improving drug development processes, offering a more predictive, ethical, and comprehensive method for drug behavior and toxicity assessments in humans. Our findings suggest that this methodology could advance early-stage drug development, potentially reducing reliance on animal testing and enabling more personalized therapeutic strategies.
Exploring Challenges Experienced by Nursing Students Regarding Objective Structured Clinical Examination in malawian Nursing Colleges: A Qualitative Phenomenology Study.
Authors: Taibu Evelyn , Phuma Ellemes , Mbakaya Balwani , Mhango Lucky , Bvumbwe Thokozani , Chipeta Mep 
Published: September 2024

Abstract

Background: Objective Structured Clinical Examination (OSCE) is a widely used clinical assessment method in health professions education. It is a reliable and objective assessment tool that accurately measures students’ clinical skills and knowledge, confirming their competence in real world practice. However, despite the OSCE being used to certify students’ clinical competency skills, many nursing students often lack the necessary clinical skills to provide quality patient care. The study aimed to explore challenges that college diploma nursing students encounter with OSCE at selected nursing colleges in Malawi.
Methods: The study employed a qualitative husserlian phenomenological design at three nursing colleges: Malawi College of Health Sciences (Zomba Campus) in the Southern Region, Nkhoma College of Health Sciences in the Central Region and St. John’s Institute for Health in the Northern Region. The study recruited fifty-three final year college diploma nursing students from the three nursing colleges using purposive sampling technique. Three focus group discussions and twenty-five in-depth interviews were conducted in English, audiotaped and later transcribed verbatim. Data from both sources were triangulated and then manually analyzed using Colaizzi’s data analysis method.
Results: Three themes related to challenges faced by nursing students regarding OSCE emerged from the Colaizzi’s data analysis. These included (1) emotional and psychological issues, notably high levels of stress and anxiety related to the OSCE, (2) administrative difficulties and (3) academic difficulties.
Conclusion: Diploma nursing students’ encounter complex challenges with OSCE in Malawi. The study findings emphasized the need for nursing education institutions to address the challenges through targeted interventions which can enhance the learning environment and produce competent nursing professionals.
Numerical simulation of MHD mixed convection Copper-Iron Oxides/water hybrid nanofluid over circular concentric tubes
Authors: Waqas Hassan , Hasan Md. Jahid , Ahmad Shafee , Muhammad Taseer 
Published: September 2024

Abstract

Researchers have explored various design parameters and conditions to identify the most suitable and efficient designs. One area of research that has shown promise is the geometric modification of concentric heat tubes under different conditions. A significant research gap is the implementation of hybrid nanofluids in concentric tubes under MHD, mixed convection changing the various heat transfer parameters. So, the present work examines the impact of the different inner radii of a concentric tube under a magnetic field and mixed convection using copper-iron oxides/water (Cu-Fe3 O4/H2O) hybrid nanofluid. The finite element method with nonlinear governmental equations has been employed for this study. The model has been validated from the past literature with minimal numerical error. The controlling parameters for the study are chosen as the inner radius (r1 =0.2, 0.4. 0.6, and 0.8), central angle 30 °≤ γ ≤ 90°, Hartmann number (0 ≤ Ha ≤ 100), Prandtl number (Pr= 0.71, 6.5, 25), Rayleigh number (103 ≤ Ra ≤ 106) and solid volume fractions (ϕ = 0.1, 0.2, 0.3, 0.4, 0.5). The results have been shown as streamlines, isotherm plots, local Nusselt number (Nu) for the inner and outer arc for variable inner radius, Ra, Pr, Ha, central angles and ϕ. The findings show that with the ascends of the inner arc length, the Nu decreases and for the outer arc length, it increases.
TUBB2B regulates epithelial-mesenchymal transition via interaction with Vimentin to promote glioma migration and invasion
Authors: Li Junxi , Zhang Junrong , Zhou Zhengjun , Wang Ming , Luan Xingzhao , Zhao Mingkuan , Jiang Geng , Wang Guiyuan , Li Shenjie , Xiang Wei , Chen Ligang , Zhou Jie 
Published: September 2024

Abstract

Background
Epithelial-mesenchymal transition (EMT) plays a crucial role in the migration and invasion capabilities of glioblastoma (GBM) cells. Several studies have established tubulin as a significant regulator of the EMT process. Tubulin beta 2B class IIb (TUBB2B), a critical component of microtubules, has been linked to the prognosis of various tumors. However, the specific biological function and mechanism of TUBB2B in GBM remain unclear.
Methods
In vitro experiments demonstrated that TUBB2B knockdown inhibited the migration and invasion of GBM cells, while its overexpression enhanced these capabilities. Western blot, immunofluorescence (IF) and co-immunoprecipitation (Co-IP) assays revealed that TUBB2B interacts with Vimentin. Molecular docking and residue mutation scanning indicated that TUBB2B interacts with Vimentin at the R391/K392/A393/F394 sites. In vivo experiments using nude mice confirmed that TUBB2B knockdown inhibited GBM cell invasion and migration.
Results
TUBB2B was upregulated in GBM tissue samples compared with normal tissues. The sites of TUBB2B(R391/K392/A393/F394) physically interacts with Vimentin to induce EMT, which promotes migration and invasion.
Conclusion
TUBB2B may regulate EMT and promote the migration and invasion of GBM cells through its interaction with Vimentin, highlighting TUBB2B as a potential therapeutic target for GBM.
Clinical outcomes and nephrotoxicity of colistin methanesulfonate in critically ill patients with carbapenem-resistant organisms infections: a retrospective study
Authors: Ren Xindie , Xu Jun , Zhou Hua , Cai Hongliu 
Published: September 2024

Abstract

Background
Carbapenem resistant organisms (CRO) infection is one of the most common causes of high mortality among critically ill patients. Colistin methanesulfonate (CMS) represents a significant treatment option for CRO infections, yet the available data on CMS in the Chinese population remains limited. This study aimed to analyze the clinical outcomes and nephrotoxicity of CMS in treating critically ill patients with CRO infections in China.
Methods
A retrospective study was conducted from June 2022 to September 2023 in critically ill patients with CRO infections who received CMS treatment. The clinical outcomes were assessed by clinical effective, microbiological eradication, infection-related hospital mortality, the length of ICU stay, and total hospital stay. A sub-group analysis was conducted on patients with lung infection. The nephrotoxicity was assessed by the acute kidney injury (AKI).
Results
A total of 96 critically ill patients with CRO infections were enrolled in the study. The overall clinical effective, microbiological eradication and infection-related hospital mortality rates were 67.90%, 60.49% and 8.33%, respectively. The median length of ICU and total hospital stays was 28 and 32.5 days, respectively. In patients with lung infection, 70.31% and 61.19% achieved clinical effective and microbiological eradication, respectively. The younger patients (< 65 years old), patients who received intravenous combined nebulized CMS, and infections caused by CRE benefitted more from CMS treatment. The incidence of acute kidney injury (AKI) was 28 cases (30.43%), with the majority (82.14%) occurring in stage 1.
Conclusions
CMS treatment in Chinese critically ill patients with CRO infections achieved favorable outcomes, with acceptable nephrotoxicity, providing a promising option for this fatal disease.