bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Laguerre spectral method as applied to
numerical solution of a two−dimensional linear
dynamic seismic problem for porous media
Authors: Berdyshev Abdumauvlen , Imomnazarov Kholmatzhon , Tang Jian-Gang , Mikhailov Aleksander 
Published: January 2017

Abstract
The initial boundary value problem of the dynamics
of fluid saturated porous media, described by three
elastic parameters in the reversible hydrodynamic approximation,
is numerically solved. A linear two-dimensional
problem as dynamic equations of porous media for components
of velocities, stresses and pore pressure is considered.
The equations of motion are based on conservation
laws and are consistent with thermodynamic conditions.
In this case, a medium is considered to be ideally
isotropic (in the absence of energy dissipation) and twodimensional
heterogeneous with respect to space. For a
numerical solution of the dynamic problem of poroelasticity
we use the Laguerre transform with respect to time and
the finite difference technique with respect to spatial coordinates
on the staggered grids with fourth order of accuracy.
The description of numerical implementation of the
algorithm offered is presented, and its characteristics are
analyzed. Numerical results of the simulation of seismic
wave fields for the test layered models have been obtained
on the multiprocessor computer.
On the simultaneous recovery of boundary heat transfer coefficient and initial heat status
Authors: Wang Yuchan , Liu Jijun 
Published: January 2017

Abstract
Consider the heat conduction process with heat flux exchanges on the boundary of a 2-dimensional domain. The aim is to identify both the boundary heat exchange coefficient and the initial heat distribution simultaneously from the final measurement data of the heat field.
We prove the uniqueness for this nonlinear inverse problem for the strictly positive exchange coefficient and initial heat distribution in terms of the maximal principle and the eigenfunction expansions. Then a regularizing scheme combining the data mollification and quasi-reversibility method along time direction together is established to recover two unknowns, with the choice strategies for the regularizing parameters and the error estimates on the regularizing solutions. The reconstruction implementations are carried out in terms of the potential representation of the heat field, with numerical examples showing the validity of the proposed scheme.
Ectopic pregnancy treatment by combination therapy
Authors: Cymbaluk-Płoska Aneta , Chudecka-Głaz Anita , Kuźniak Sławomir , Menkiszak Janusz 
Published: January 2017

Abstract
Detectability of early stages of ectopic pregnancies has increased due to improvements in ultrasonographic and biochemical techniques. Since the patients’ future procreative plans must be taken into consideration when commencing treatment, the goal of this work was to compare the effects of treatment methods and their impact on fertility. The study included 91 patients treated surgically for ectopic pregnancy. The choice of treatment depended on patients’ general condition, ultrasonographic evaluation and serum level of beta-hCG. A combination of laparoscopic and conservative systemic treatment was applied in 70% of cases. More rapid beta-hCG reduction was noted when laparoscopy and intra-oviductal injection of hyperosmolar glucose or methotrexate (MTX) were combined with intramuscular administration of MTX at a dose of 50 mg/m2. Follow-up examination of 66 patients revealed that the greatest number of spontaneous pregnancies (48%) resulted after this combination therapy. We conclude that this combination treatment is safe and provides satisfactory results in terms of future fertility.
A meta-analysis of association between glutathione S-transferase M1 gene polymorphism and Parkinson’s disease susceptibility
Authors: Weikang Chen , Jie Li , Likang Lan , Weiwen Qiu , Liping Lu 
Published: January 2017

Abstract
The aim of this meta-analysis was to evaluate whether there was an association between glutathione S-transferase M1(GSTM1)gene polymorphism and Parkinson’s disease (PD) susceptibility by pooling published data.
We performed comprehensive electronic database search for articles published between February12,2015 and April30 2016. The published case-control or cohort studies related to GSTM1 gene polymorphism and Parkinson’s disease susceptibility were screened, reviewed, and included in this meta-analysis. The correlation between GSTM1 gene polymorphism and PD susceptibility was expressed by odds ratio (OR) and its corresponding 95% confidence interval (95%CI). Publication bias was evaluated by Begg’s funnel plot and Egger’s line regression test. All analysis was done by stata11.0 software.
After searching the PubMed, EMBASE, and CNKI databases, seventeen case-control studies with 3,538 PD and 5,180 controls were included in the final meta-analysis. The data was pooled by a fixed-effect model for lack of statistical heterogeneity across the studies; the results showed GSTM1 null expression can significant increase the susceptibility of PD (OR=1.11, 95% CI:1.01-1.21, P<0.05). Subgroup analysis indicated GSTM1 gene polymorphism was associated with PD susceptibility in the Caucasian ethnic group (OR=1.15, 95% CI:1.05-1.27, P<0.05) but not in the Asian ethnic group (OR=0.89, 95% CI:0.70-1.12, P>0.05). Begg’s funnel plot and Egger’s line regression test showed no significant publication bias.
Based on the present evidence, GSTM1 null expression can significant increase the susceptibility of PD in persons of Caucasian ethnicity.
Plastination: ethical and medico-legal considerations
Authors: Bin Paola , Conti Adelaide , Buccelli Claudio , Addeo Giuseppe , Capasso Emanuele , Piras Mauro 
Published: January 2017

Abstract
The international plastination phenomenon has proved to be immensely popular with audiences world-wide. Never before has the human body been exposed to public gaze in such an accessible manner. The exhibitions have perplexed many, included anatomists, some of whom find the display of human bodies unethical. The objective of this study is to review the attention on the use of plastination and exhibition of entire human bodies for non-educational or commercial purposes. The nature of these exhibitions and the uneasy balance between entertainment and education has caused heated debate. The possible legitimacy of the expression of one’s will as far as exhibition purposes isn’t considered sufficient for the indiscriminate use of a corpse despite the ethical necessity of respecting the wishes of individuals based on respect for the deceased. The informed consent of an individual represents only the most basic and minimal prerequisite for the use of the deceased’s body for exhibition purposes, and is absolutely not enough on its own to justify its use in entertainment exhibitions or for the commercialization of the death
A study on validating KinectV2 in comparison of Vicon system as a motion capture system for using in Health Engineering in industry
Authors: Jebeli Mahvash , Bilesan Alireza , Arshi Ahmadreza 
Published: January 2017

AbstractThe currently available commercial motion capture systems are constrained by space requirement and thus pose difficulties when used in developing kinematic description of human movements within the existing manufacturing and production cells. The Kinect sensor does not share similar limitations but it is not as accurate. The proposition made in this article is to adopt the Kinect sensor in to facilitate implementation of Health Engineering concepts to industrial environments. This article is an evaluation of the Kinect sensor accuracy when providing three dimensional kinematic data. The sensor is thus utilized to assist in modeling and simulation of worker performance within an industrial cell. For this purpose, Kinect 3D data was compared to that of Vicon motion capture system in a gait analysis laboratory. Results indicated that the Kinect sensor exhibited a coefficient of determination of 0.9996 on the depth axis and 0.9849 along the horizontal axis and 0.2767 on vertical axis. The results prove the competency of the Kinect sensor to be used in the industrial environments.
Nanotechnology and its medical applications: revisiting public policies from a regulatory perspective in Australia
Authors: Solaiman S.M. , Yamauchi Yusuke , Kim Jung Ho , Horvat Joseph , Dou Shi Xue , Alici Gursel , Ooi Lezanne , Martinac Boris , Shiddiky Muhammad J.A. , Gopalan Vinod , Hossain Md Shahriar A. 
Published: January 2017

AbstractNanobiotechnology is an immensely potential invention, which is expected to bring about revolutionary changes in many aspects of essential human needs including medical treatments and foods. Although the technology has passed through its embryonic stage, its medical applications in preparing and delivering drugs to target cells of human bodies to cure incurable diseases are still under scientific scrutiny. A 2007 study suggests that Australia needs to have a review of its regulatory framework for nanotechnology by 2017. This article examines the current regulation of nanotechnology and its medical applications in Australia, and observes that it would be premature to impose any stringent regulation at this stage on medical experimentations. We are of the view that an excessively precautionary policy may hinder further research, which is critical to discovering the benefit and harm with certainty. Hence, in the greater interest of the facilitation of research and affirmation of benefits of this technology, we recommend that adopting a hybrid regulatory method composed of self-regulation and accommodating government regulation would be an appropriate policy approach to the regulation of nanobiotechnology. We also accept the need for a set of internationally harmonized policy principles to guide our actions in relation to this technology.
Recognition of Phytophthora infestans in potato
(Solanum tuberosum L.): Scr74 gene as an
example
Authors: Bitew Mulusew Kassa , Domazakis Emmanouil 
Published: January 2017

Abstract
Phytophthora infestans is the causal agent of late
blight, the most devastating disease of potato worldwide.
The P. infestans genome encodes potentially polymorphic
genes that evolve continually to evade the recognition of
plant R genes, though it has hundreds of predicted and
conserved effector proteins recognised by the plant. The
gene Scr74 encodes a predicted 74-amino acid secreted
cysteine-rich protein belonging to a highly polymorphic
gene family within P. infestans. This study screened the
recognition of Scr74 genes in wild potato genotypes
from August 2013 to January 2014 in the Plant Breeding
Laboratory of Wageningen University, the Netherlands. To
identify the recognition of the Scr74 gene, we grew potato
genotypes in the green house for PVX assays, detached leaf
assays and molecular work. Twenty-seven good-quality
sequences of the Scr74 gene variant with a length of 74
amino acids were found and more frequent amino acid
variation was detected on the mature protein. Seventeen
Scr74 constructs were identified as diversified and two
effectors were strongly recognised by wild S. verrucosum
genotypes via effectoromics from the PVX assay. A strong
plant cell death hypersensitive response (HR) was recorded
on wild S. verrucosum and S. tuberosum genotypes from
the detached leaf assay. This recognition seems to be a
useful indicator for the presence of a resistance gene (s) to
the polymorphic effectors of P. infestans (as it has seen on
Scr74 gene) in the wild potato genotypes.
Positioning and aligning CNTs by external magnetic field to assist localised epoxy cure
Authors: Ariu G. , Hamerton I. , Ivanov D. 
Published: January 2017

Abstract
This work focuses on the generation of conductive networks through the localised alignment of nano fillers, such as multi-walled carbon nanotubes (MWCNTs). The feasibility of alignment and positioning of functionalised MWCNTs by external DC magnetic fields was investigated. The aim of this manipulation is to enhance resin curing through AC induction heating due to hysteresis losses from the nanotubes. Experimental analyses focused on in-depth assessment of the nanotube functionalisation, processing and characterisation of magnetic, rheological and cure kinetics properties of the MWCNT solution. The study has shown that an external magnetic field has great potential for positioning and alignment of CNTs. The study demonstrated potential for creating well-ordered architectures with an unprecedented level of control of network geometry. Magnetic characterisation indicated cobalt-plated nanotubes to be the most suitable candidate for magnetic alignment due to their high magnetic sensitivity. Epoxy/metal-plated CNT nanocomposite systems were validated by thermal analysis as induction heating mediums. The curing process could therefore be optimised by the use of dielectric resins. This study offers a first step towards the proof of concept of this technique as a novel repair technology.
Prüftechnik und deren Einfluss bei der Kalibrierung von Messwandlern
Authors: Mohns Enrico , Räther Peter 
Published: January 2017

Zusammenfassung
Bei der Richtigkeitsprüfung von Messwandlern für Verrechnungszwecke in anerkannten Stellen müssen zukünftig
Unsicherheitsnachweise im Rahmen des Qualitätsmanagements erbracht werden. Im vorliegenden Beitrag werden daher die
Messabweichungen von Messwandlern definiert und deren Ursachen analysiert. Die Rückführung der relevanten Prüfmittel für
die Messwandlerprüfung auf die nationalen Normale der PTB wird zusammen mit den erreichbaren Messunsicherheiten und den
erlaubten Grenzwerten dargestellt. Abschließend ist ein Beispiel einer Messunsicherheitsbilanz für einen Stromwandler der
Klasse 0, 2S angegeben.
Eye Movements in Darkness Modulate Self-Motion Perception
Authors: Clemens Ivar Adrianus H. , Selen Luc P. J. , Pomante Antonella , MacNeilage Paul R. , Medendorp W. Pieter 
Published: January 2017

AbstractDuring self-motion, humans typically move the eyes to maintain fixation on the stationary environment around them. These eye movements could in principle be used to estimate self-motion, but their impact on perception is unknown. We had participants judge self-motion during different eye-movement conditions in the absence of full-field optic flow. In a two-alternative forced choice task, participants indicated whether the second of two successive passive lateral whole-body translations was longer or shorter than the first. This task was used in two experiments. In the first (n= 8), eye movements were constrained differently in the two translation intervals by presenting either a world-fixed or body-fixed fixation point or no fixation point at all (allowing free gaze). Results show that perceived translations were shorter with a body-fixed than a world-fixed fixation point. A linear model indicated that eye-movement signals received a weight of ∼25% for the self-motion percept. This model was independently validated in the trials without a fixation point (free gaze). In the second experiment (n= 10), gaze was free during both translation intervals. Results show that the translation with the larger eye-movement excursion was judged more often to be larger than chance, based on an oculomotor choice probability analysis. We conclude that eye-movement signals influence self-motion perception, even in the absence of visual stimulation.
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway
Authors: Zheng Honghua , Jia Lin , Liu Chia-Chen , Rong Zhouyi , Zhong Li , Yang Longyu , Chen Xiao-Fen , Fryer John D. , Wang Xin , Zhang Yun-wu , Xu Huaxi , Bu Guojun 
Published: January 2017

Triggering Receptor Expressed on Myeloid cells 2 (TREM2), which is expressed on myeloid cells including microglia in the CNS, has recently been identified as a risk factor for Alzheimer's disease (AD). TREM2 transmits intracellular signals through its transmembrane binding partner DNAX-activating protein 12 (DAP12). Homozygous mutations inactivating TREM2 or DAP12 lead to Nasu–Hakola disease; however, how AD risk-conferring variants increase AD risk is not clear. To elucidate the signaling pathways underlying reduced TREM2 expression or loss of function in microglia, we respectively knocked down and knocked out the expression of TREM2 inin vitroandin vivomodels. We found that TREM2 deficiency reduced the viability and proliferation of primary microglia, reduced microgliosis inTrem2−/−mouse brains, induced cell cycle arrest at the G1/S checkpoint, and decreased the stability of β-catenin, a key component of the canonical Wnt signaling pathway responsible for maintaining many biological processes, including cell survival. TREM2 stabilized β-catenin by inhibiting its degradation via the Akt/GSK3β signaling pathway. More importantly, treatment with Wnt3a, LiCl, or TDZD-8, which activates the β-catenin-mediated Wnt signaling pathway, rescued microglia survival and microgliosis inTrem2−/−microglia and/or inTrem2−/−mouse brain. Together, our studies demonstrate a critical role of TREM2-mediated Wnt/β-catenin pathway in microglial viability and suggest that modulating this pathway therapeutically may help to combat the impaired microglial survival and microgliosis associated with AD.SIGNIFICANCE STATEMENTMutations in theTREM2(Triggering Receptor Expressed on Myeloid cells 2) gene are associated with increased risk for Alzheimer's disease (AD) with effective sizes comparable to that of the apolipoprotein E (APOE) ε4 allele, making it imperative to understand the molecular pathway(s) underlying TREM2 function in microglia. Our findings shed new light on the relationship between TREM2/DNAX-activating protein 12 (DAP12) signaling and Wnt/β-catenin signaling and provide clues as to how reduced TREM2 function might impair microglial survival in AD pathogenesis. We demonstrate that TREM2 promotes microglial survival by activating the Wnt/β-catenin signaling pathway and that it is possible to restore Wnt/β-catenin signaling when TREM2 activity is disrupted or reduced. Therefore, we demonstrate the potential for manipulating the TREM2/β-catenin signaling pathway for the treatment of AD.
Distinct inflammatory gene expression in extraocular muscle and fat from patients with Graves’ orbitopathy
Authors: Romero-Kusabara Ivana Lopes , Filho José Vital , Scalissi Nilza Maria , Melo Keli Cardoso , Demartino Giovanni , Longui Carlos Alberto , Melo Murilo Rezende , Cury Adriano Namo 
Published: January 2017

Objective
This study sought to compare patients with thyroid eye disease (TED) and normal controls with respect to the expression of the NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1 genes in orbital fat (OF) and extraocular muscle (EOM).

Design and methods
A prospective study design was used to evaluate 34 TED patients and 38 healthy controls. OF was harvested from 33 TED patients and 27 controls. EOM biopsies were obtained from 32 TED patients and 18 controls. Samples were examined by real-time PCR and evaluated using appropriate statistical analyses with a significance cut-off of P < 0.05.

Results
NR3C1 mRNA levels were higher in TED EOM (median 213 (96–376)) than those in control EOM (78 (34–138)) (P < 0.001), and NFKB expression was elevated in TED muscle (223 (31–520)) relative to that in control muscle (8 (6–31)) (P < 0.001). HSD11B1 expression was higher in TED EOM (0.78 (0.47–2.01)) than that in control EOM (0.22 (0.09–0.51)) (P < 0.001). Levels of CHUK, IKBKB, and FOS were higher in TED EOM (115 (20–223), 111 (54–299) and 0.11 (0.03–0.19), respectively) than those in control EOM (5.8 (2–13), 21 (5–52) and 0.05 (0.001–0.03) respectively) (P < 0.001).

Conclusion
Tissues involved in GO exhibited different mRNA levels of NR3C1, CHUK, IKBKB, FOS, NFKB and HSD11B1. Gene expression in OF was similar for TED patients and controls. CHUK, IKBKB, FOS, NFKB, and HSD11B1 mRNA levels were higher in TED EOM than those in control EOM. NFKB was disproportionally elevated compared with NR3C1; this finding was indicative of a local proinflammatory profile.
Improving Early Identification and Intervention for Children at Risk for Autism Spectrum Disorder
Authors: Rotholz David A. , Kinsman Anne M. , Lacy Kathi K. , Charles Jane 
Published: January 2017

OBJECTIVES:
To provide an example of a successful, novel statewide effort to increase early identification of young children at risk for autism spectrum disorder (ASD) using a 2-tiered screening process with enhanced quality assessment, interagency policy collaboration and coordination.

METHODS:
The South Carolina Act Early Team (SCAET) provided focused collaboration among leaders representing state agencies, universities, health care systems, private organizations, and families to improve quality of life for children with ASD. Specific focus was on implementing policy changes and training to result in earlier identification and home-based behavioral intervention for young children at risk for ASD.

RESULTS:
Policy changes, training, and modified state agency practices were accomplished. Presumptive eligibility, on the basis of a 2-tiered screening process was implemented by BabyNet (South Carolina’s Early Intervention Program) in collaboration with the lead agency for developmental disability services. There was a fivefold increase in children eligible for early intensive behavioral intervention without waiting for a diagnosis of ASD, avoiding long waits for diagnostic evaluations. Only 16 children (2.5%) were later found not to have ASD from a comprehensive evaluation.

CONCLUSIONS:
Improvements in early identification and intervention are feasible through collaborative policy change. The South Carolina Act Early Team and its key stakeholders committed to improving outcomes for this population used existing tools and methods in new ways to improve early identification of children with ASD and to make available evidence-based intervention services. This example should be replicable in other states with key stakeholders working collaboratively for the benefit of young children with ASD.
Estudio de seguimiento a personas graduadas de postgrados de la Facultad de Ciencias Sociales y Humanísticas (FCSH) de la Escuela Superior Politécnica del Litoral (ESPOL)
Authors: Rodriguez-Morales Katia Lorena , Valenzuela-Ortiz Mónica Giomary 
Published: January 2017

Este artículo muestra la situación de los sujetos graduados del Departamento de Postgrado de la Facultad de Ciencias Sociales y Humanísticas (FCSH) de la Escuela Superior Politécnica del Litoral (ESPOL), en relación con su perfil general, evaluación de la enseñanza recibida, la pertinencia de los programas en el entorno en el que se desenvuelven, el impacto en su empleo, entre otros aspectos, en 5 programas de maestrías activos e inactivos de la Facultad. El estudio, con enfoque cuantitativo-descriptivo, consideró a las 273 personas graduadas hasta julio de 2014. Además, se aplicó un cuestionario en línea utilizando la herramienta Google Drive. Con las conclusiones de este estudio, se amplía la información con la que se contaba sobre este grupo de ex-estudiantes, ayudando así a tomar medidas y plantear recomendaciones que contribuirán a mantener los procesos de mejora continua de la unidad académica.