bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Progress on Structure and Bioactivity of Polysaccharides from Platycodon grandiflorum
Authors: Chen Jiaxin , Ji Xiaolong , Du Xin , Xu Rongling , Shi Fengcheng , Guo Xudan 
Published: September 2024

AbstractPlatycodon grandiflorum is a commonly used Chinese herbal medicine in China, containing saponins, flavonoids, phenolic compounds, fatty acids, volatile oils, polysaccharides, and other active ingredients. It has the effects of regulating immunity, anti‐inflammatory, expectorant, lowering blood lipids, antioxidation, etc., and can be used to treat symptoms such as cough, sore throat, lung pain, and expectoration. Polysaccharides are one of the important bioactive substances in P. grandiflorum, which have better anti‐tumor and enhancing immune activity, and are widely used in medicine, health food, and other fields. P. grandiflorum polysaccharide (PGP) has various biological activities and is the main component and key bioactive substance of P. grandiflorum. It has various biological effects, including immune regulation, antioxidant, anti‐tumor, liver protection, hypoglycemic, and gastrointestinal protection. This paper systematically reviews the research progress on the extraction, separation and purification, structural characteristics, and biological activity of P. grandiflorum polysaccharides in recent years both domestically and internationally, to provide the theoretical basis for improving the utilization of P. grandiflorum polysaccharides and further studying the structure–activity relationship of P. grandiflorum polysaccharides.
An improved Chinese load code method for the evaluation of wind‐induced base shear force on base‐isolated buildings
Authors: Zhou Hehong , Lie Wenchen 
Published: September 2024

AbstractThe isolator units in a seismically isolated structure shall have a surplus yield strength under wind loads. The isolation interface must have enough strength to state at an elastic stage under wind loads. This necessitates an accurate evaluation of wind‐induced base shear force. Initially, to calculate the equivalent static wind load (ESWL) and the base shear force of a base‐isolated building, the validity of the inertial wind load (IWL) method and Chinese load code (CLC) method, the simplification based on the IWL method, are examined via comparison with response‐history analysis results. Comparative analysis reveals that the IWL method was more accurate in evaluating the ESWL and the base shear force of base‐isolated building, while the CLC method underestimated them due to the following reasons: inaccurate fundamental modal shape, a reduced peak factor, the omission of the ESWL contribution from the isolation interface, and flawed assumptions of uniform mass distribution. Subsequently, an improved CLC method that combined the exponential modal shape and first modal generalized mass modification coefficient is proposed and verified by a case study. Compared with the CLC method, the fluctuating base shear force calculated by the improved CLC method increased by 10% in the case study. Finally, the effect of non‐uniformly distributed mass is further considered in the proposed method by devising a mass conversion coefficient, and the case study has also validated this method. Without considering the effect of the non‐uniform mass, the fluctuating base shear force will be underestimated by 7.8% in the case study.
Primary mast cell tumour of the soft palate in a dog
Authors: Frapwell Emily , Harper Aaron , Hall Jon 
Published: September 2024

AbstractA 12‐year‐old, male, entire Labrador retriever was presented to its primary care practice with a history of vomiting. A soft tissue mass was identified within the soft palate. Cytology from a fine‐needle aspirate revealed atypical mast cells, consistent with a mast cell tumour. Initial staging included complete blood count, serum biochemistry, serum electrolyte assay, thoracic, abdominal and cervical radiographs, computed tomography of the head and neck, and ultrasound‐guided aspirates of the retropharyngeal lymph nodes, liver and spleen. No evidence of nodal or distant metastasis was identified, and a diagnosis of primary soft palatal mast cell tumour was made. The dog underwent staphylectomy followed by adjunctive chemotherapy. Repeat staging was performed, which did not identify any evidence of metastasis. The dog died 22 months after initial presentation from an unknown cause.
Shoulder arthrodesis in a cat with humeral head dysplasia
Authors: Singh Miren , Solano Miguel Angel , Elmenhorst Kine 
Published: September 2024

AbstractShoulder arthrodesis is a recognised procedure for incapacitating shoulder conditions in dogs in cases where traditional surgical or medical interventions are not feasible. However, the use of shoulder arthrodesis in the feline patient has not been described. This case report details the novel use of shoulder arthrodesis in a 10‐month‐old cat with a chronic right forelimb lameness attributed to humeral head dysplasia. Surgical stabilisation of the right shoulder arthrodesis was achieved with two 2.4 mm Synthes locking compression plates and two 2.4 mm inter‐fragmentary positional screws. Short‐term follow‐up indicated adequate bone healing with good alignment and implant integrity. Subsequent long‐term phone follow‐up 22 months after surgery revealed a successful outcome with no visible stiffness and only a mechanical lameness. This result underscores the viability of shoulder arthrodesis as a potential option for feline patients necessitating shoulder salvage procedures.
Terrorist Trials Under Literary Scrutiny: Literature as Counterterrorist Response
Authors: Folkvord Ingvild , Lassègue Jean 
Published: September 2024

Abstract Judicial trials are recognized as important steps when societies are trying to come to terms with terrorist attacks. And yet trials are often thought of either as final conclusions that can settle the matter of justice once for all or criticized as utterly insufficient, unable to reach what matters to individuals (grief, mourning, recognition and justice). In both cases, individuals are silenced as they are reduced to the status of “victims”, and their way of dealing with their own personal reconstruction being left aside. This article therefore investigates how literary responses to terrorist attacks can go beyond this conundrum and play a specific role in maintaining and developing a collective level of awareness that law, as it is performed in these very specific trials, does not cover the whole meaning of justice and injustice.Based on literary examples from three different European contexts, Norway, Germany and France, we show various literary strategies that enable reflection on the trials themselves and on the ‘sense of injustice’ (Skhlar 1990) that remains forceful and needs to be addressed after trials are brought to an end: there is still something to be reflected upon collectively once justice has tried to establish a measure for the damages suffered. Three literary texts focused on trials are explored: Endre Ruset’s Prosjektil (2012), Yannick Haenel’s Notre solitude (2021), and Kathrin Röggla’s Verfahren (2022), all belonging to the same European post 9/11 era. Our aim is to point out how a literary re-working of judicial material, ideas and versions of the past takes place, pushing the borders of what can be thought, imagined and felt after extreme experiences of crisis and rupture.
Out in the Open
Authors: Ibarrola Jose 
Published: September 2024

Abstract​An umbrella is, in itself, a curious paradox; for although we think we are sheltered, it only protects us from the rain and yet we always end up wet. The umbrella we beg for when it starts to rain is of no use to us when the storm breaks. It simply makes us feel covered in the open. Following the assassination of Jose Luis López de Lacalle at the hands of ETA, Jose Ibarrola would create his series ‘Memory and Umbrellas’ to speak about objects, images, remembrance, absence, emotions, metaphors, and tribute. Painting, for him, is an exercise of memory.
The Origin of Music and Its Specific Characteristics (the Historical-Ontological Aspect)
Authors: Rimas Juozas , Rimas Jr Juozas 
Published: September 2024

AbstractThe etymology of the word “music” (Isidore of Seville, the Li Ki). The importance of music in the formation of personality (Plato). The relationship between music and numbers (Pythagoras, G. W. Leibniz, A. Schopenhauer, V. Sesemann). St Augustine’s definition of music as the ability to modulate well (scientia bene modulandi). Primeval speech as primeval song (R. Steiner). The primacy of music over the text in two traditional Lithuanian harvest songs: Bėk, barali (“Run, little row of rye”) and Vai tu, rugeli (“O, you little rye”) (links to recordings, sung by the author). Music as an art of motion detected in intonations: relation of this definition of B. Asaf’ev to ideas of movement expressed by authors of different epochs (Heraclitus; St Augustine, who describes music as the science of moving well (scientia bene movendi); A. Losev, who considers continuous change is the main characteristic of music). Comparison of the expression of music with reading, which H. Gadamer defines as a constant hermeneutic movement guided by anticipation of the whole. Without expression, a piece of music is only the potential repository of intonations and a question in suspense awaiting an answer (and this answer is an expression which fulfils the idea of the work).
The Logic of Music
Authors: Rimas Juozas , Rimas Jr Juozas 
Published: September 2024

AbstractThe harmonic regulation of tonal relations as “musical logic,” following J. N. Forkel. The relationship between musical logic and language (J. N. Forkel, E. Hanslick; C. Dahlhaus). Language as the house of being (M. Heidegger): musical language as a way of manifesting the being of music (its idea). The thematic logic of music (F. Schlegel). “Forms set in motion by sounding” as the sole content of music (E. Hanslick): the idea, which appears in the musical material, Hanslick called “form.” The exaltation of articulated sound to the expression of thought makes up the form of language (W. von Humboldt). Music is first and last in relation to language: interjection versus lyricism (S. Kierkegaard). Absolute music as language above language (T. W. Adorno). The inner logic of music (L. B. Meyer; S. Langer; J. Shepherd). Music brings an encounter with a logic of sense other than that of reason (G. Steiner).
Something About Rhythm
Authors: Rimas Juozas , Rimas Jr Juozas 
Published: September 2024

AbstractThe concept of rhythm is compared with bar, meter, cadence (G. Hegel, F. Couperin) and tempo (W. Landowska). Rhythmic organisation can be seen in ancient poetic composition. Melodic rhythm expresses the true accents of the music. Also, there is a demonstration of the energetic quality of musical movement illustrated by a recording of Rondino by Jean Sibelius (Op. 81, No. 2) for oboe and piano, with the author playing oboe.
A plethora of long-range neutrino interactions probed by DUNE and T2HK
Authors: Agarwalla Sanjib Kumar , Bustamante Mauricio , Singh Masoom , Swain Pragyanprasu 
Published: September 2024

Abstract
Upcoming neutrino experiments will soon search for new neutrino interactions more thoroughly than ever before, boosting the prospects of extending the Standard Model. In anticipation of this, we forecast the capability of two of the leading long-baseline neutrino oscillation experiments, DUNE and T2HK, to look for new flavor-dependent neutrino interactions with electrons, protons, and neutrons that could affect the transitions between different flavors. We interpret their sensitivity in the context of long-range neutrino interactions, mediated by a new neutral boson lighter than 10−10 eV, and sourced by the vast amount of nearby and distant matter in the Earth, Moon, Sun, Milky Way, and beyond. For the first time, we explore the sensitivity of DUNE and T2HK to a wide variety of U(1)′ symmetries, built from combinations of lepton and baryon numbers, each of which induces new interactions that affect oscillations differently. We find ample sensitivity: in all cases, DUNE and T2HK may constrain the existence of the new interaction even if it is supremely feeble, may discover it, and, in some cases, may identify the symmetry responsible for it.
Infinite and finite consistent truncations on deformed generalised parallelisations
Authors: Blair Chris D. A. , Pico Martín , Varela Oscar 
Published: September 2024

Abstract
Given a manifold $$ \mathbbm{M} $$
M
admitting a maximally supersymmetric consistent truncation, we show how to formulate new consistent truncations by restricting to a set of Kaluza-Klein modes on $$ \mathbbm{M} $$
M
invariant under some subgroup of the group of isometries of $$ \mathbbm{M} $$
M
. These truncations may involve either finite or infinite sets of modes. We provide their global description using exceptional generalised geometry to construct a ‘deformed’ generalised parallelisation starting with that on $$ \mathbbm{M} $$
M
. This allows us to explicitly embed known consistent truncations directly into exceptional generalised geometry/exceptional field theory, and to obtain the equations governing situations where the consistent truncation retains an infinite tower of modes.
Revising pathogenesis of AP1S1-related MEDNIK syndrome: a missense variant in the AP1S1 gene as a causal genetic lesion
Authors: Rackova Marketa , Mattera Rafael , Svaton Michael , Fencl Filip , Kanderova Veronika , Spicakova Karolina , Park Sang Yoon , Fabian Ondrej , Koblizek Miroslav , Fronkova Eva , Bonifacino Juan S. , Skvarova Kramarzova Karolina 
Published: September 2024

Abstract
MEDNIK syndrome is a rare autosomal recessive disease characterized by mental retardation, enteropathy, deafness, peripheral neuropathy, ichthyosis, and keratoderma, and caused by variants in the adaptor-related protein complex 1 subunit sigma 1 (AP1S1) gene. This gene encodes the σ1A protein, which is a subunit of the adaptor protein complex 1 (AP-1), a key component of the intracellular protein trafficking machinery. Previous work identified three AP1S1 nonsense, frameshift and splice-site variants in MEDNIK patients predicted to encode truncated σ1A proteins, with consequent AP-1 dysfunction. However, two AP1S1 missense variants (c.269 T > C and c.346G > A) were recently reported in patients who presented with severe enteropathy but no additional symptoms of MEDNIK. This condition was described as a novel non-syndromic form of congenital diarrhea caused specifically by the AP1S1 missense variants. In this study, we report two patients with the same c.269 T > C variant, who, contrary to the previous cases, presented as complete MEDNIK syndrome. These data substantially revise the presentation of disorders associated with AP1S1 gene variants and indicate that all the identified pathogenic AP1S1 variants result in MEDNIK syndrome. We also provide a series of functional analyses that elucidate the impact of the c.269 T > C variant on σ1A function, contributing to a better understanding of the molecular pathogenesis of MEDNIK syndrome.

Key messages

A missense AP1S1 c.269 T > C (σ1A L90P) variant causes full MEDNIK syndrome.

The σ1A L90P variant is largely unable to assemble into the AP-1 complex.

The σ1A L90P variant fails to bind [DE]XXXL[LI] sorting motifs.

The σ1A L90P variant results in loss-of-function of the protein.
The Most Influential Publications Regarding Hair Transplantation: A Bibliometric Review
Authors: Lizardi Juan J. , Treger Dylan , Braud Savannah C. , Boghosian Tanya , Abd Rawan El , Jabori Sinan K. , Thaller Seth R. 
Published: September 2024

Abstract

Introduction
This bibliometric review aims to assess the impact of significant publications within the field of hair transplantation. Citation counts will serve as a primary influence indicator.

Methods
An exhaustive search was conducted using Clarivate’s Web of Science database, yielding 260 publications related to hair transplantation. These were evaluated and sorted based on citations, narrowing down to the 50 most highly cited works for analysis. Parameters including citation density, authorship, institutional affiliations, country of origin, year of publication, article topic, and the level of evidence for each publication were obtained.

Results
Analyzed publications were cited a total of 1341 times. Authorship analysis revealed that the most significant contributors regarding hair transplantation were Bernstein and Rassman. We also identified the leading institutions affiliated with these works, highlighting the primary academic and research centers driving the field. Geographical analysis exhibited the US' dominance in producing impactful publications. Most publications were also classified within Level IV and Level V according to the Oxford Levels of Evidence system.

Conclusion
This review provides a comprehensive snapshot of the pivotal publications shaping hair transplantation. Our findings underscore significant contributions within this field and may assist researchers and clinicians in understanding the evolution and the current state of the hair transplantation literature. This bibliometric analysis can serve as a roadmap for those seeking to delve into this rapidly evolving field, facilitating the identification of research gaps and formulating future research directions.

Level of Evidence V
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
Systems Modeling of the Water-Energy-Food-Ecosystems Nexus: Insights from a Region Facing Structural Water Scarcity in Southern Spain
Authors: Hurtado Antonio R. , Mesa-Pérez Enrique , Berbel Julio 
Published: September 2024

AbstractThe complex relationship between water, energy, food, and ecological systems, known as the WEFE nexus, has emerged as a major topic in the debate about sustainable economic development and resource management. This subject is of special interest in Mediterranean coastal areas as rapid economic expansion driven by population growth, higher influx of tourists, and intensification of agriculture is leading to structural water scarcity conditions. However, addressing the diverse range of issues associated with the nexus is a difficult task due to the existence of intricate interconnections, interdependencies, and nonlinearities within and across its various components. Accordingly, this case study applies a combination of participatory systems modeling and network analysis tools to yield insights into the complexity of this nexus in Axarquia, a region with features that make it an example of water-stressed jurisdictions in the Mediterranean. Overall, our results provide a strong foundation to understand the dynamics that govern this nexus in regions where the availability of freshwater resources is a significant concern. Furthermore, they lay the groundwork for the development of models and scenarios to simulate the impact of various policies and interventions on the overall system.
Retrospective study on the outcomes and satisfaction with endometrial ablation by bipolar energy (NovaSure®) for the treatment of heavy menstrual bleeding
Authors: Alvarez López Covadonga , González Paredes Aida , Martínez Morales Sonia , Aguilar Romero Maria Teresa , Gutiérrez Simón Mónica , Fernández Parra Jorge , Hernández Gutiérrez Alicia 
Published: September 2024

Abstract
Purpose
To determine the effectiveness, safety, and participant satisfaction with endometrial ablation by bipolar energy (NovaSure®) in the treatment of heavy menstrual bleeding (HMB), and to investigate factors associated with poorer outcomes.

Methods
Multicenter retrospective observational study based on medical record review of the outcomes related to endometrial ablation by the bipolar-energy technique procedure to treat HMB in the setting of three university teaching hospitals in Spain.

Results
A total of 333 women were included in the study. Most bipolar-energy ablations were successful (85.12%; n = 269 out of 316), with amenorrhea the most frequent outcome (39.6%, n = 131 out of 316). The majority of participants had no complications (95.5%; n = 317 out of 332), and of those who did, only 2.1% were related to the technique. No further treatment was required for HMB in 82.8% of women (n = 274 out of 331), and surgery was avoided in 91.8%; only 5.9% of women underwent ablation-related hysterectomy. In women with previous transverse cesarean sections (CS), 91.0% avoided subsequent surgical treatment. Eighty-six percent of women (n = 221 out of 257) were satisfied with the procedure.

Conclusion
Bipolar-energy ablation is very effective and safe for the treatment of HMB and yielded a high rate of participant satisfaction in our setting. The presence of comorbidities or previous CS may slightly reduce the effectiveness of the method, while performing concomitant surgery (mainly curettage) increases the rate of complications. Notably, despite the known increased risk of hysterectomy, most participants with previous CSs who underwent ablation avoided major surgery.
Evaluating cochlear implant outcomes in DFNA9 subjects: a comprehensive study on cerebral white matter lesions and vestibular abnormalities
Authors: Fehrmann M.L.A. , Meijer F.J.A. , Mylanus E.A.M. , Pennings R.J.E. , Lanting C.P. , Huinck W.J. 
Published: September 2024

Abstract

Purpose
This study assessed whether the Fazekas score could account for the variability in cochlear implantation (CI) outcomes among individuals with DFNA9 and evaluated signal loss in the semicircular canals (SCCs) on magnetic resonance imaging (MRI) among individuals with DFNA9.

Method
This retrospective cross-sectional study included CI recipients with DFNA9. Pre-implantation MRI-scans were reviewed to determine the Fazekas score, localizing and grading cerebral white matter lesions (WML), and identify abnormalities in the SCCs. CI performance was assessed by evaluating phoneme scores one year post-implantation. The function of the SCCs was evaluated using rotatory chair testing with electronystagmography (ENG) and the video Head Impulse Test (vHIT).

Results
Forty-five subjects (49 ears) were enrolled. The phoneme scores significantly improved from 35% (IQR 11–50) pre-implantation to 84% (IQR 76–90) one year post-implantation. No correlation was observed between the Fazekas score and the one-year post-implantation phoneme score (rsp=0.003, p = 0.986). Signal loss in at least one SCCs was detected in 97.7% of subjects and 77.8% of ears. There was no correlation between vestibular test results and fluid signal loss in the SCCs on MRI.

Conclusion
Most individuals with DFNA9 show improved speech recognition with CI. The observed variability in CI outcomes was not linked to the Fazekas score. Additionally, our study confirms a high prevalence of focal sclerosis in DFNA9. Recognizing the limitations of this study, further research is needed to explore the predictive role of the Fazekas score on CI outcomes and its relationship with vestibular function.