bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bilateral anterior shoulder dislocation
Authors: Rudy Bruce S. , Hennrikus William L. 
Published: June 2017

ABSTRACT
Shoulders are the most common major joint to become disarticulated, and shoulder dislocation is a frequent patient presentation to the ED. Bilateral shoulder dislocations, however, are rare and typically caused by seizure activity or electrocution. Posterior disarticulation is most common following seizure activity. This article describes an adolescent girl who dislocated both shoulders anteriorly following seizure activity.
What do PAs need to know about prescription drug monitoring programs?
Authors: Mospan Geoffrey A. , Lucas Austin 
Published: June 2017

ABSTRACT
As controlled-substance abuse continues to increase in the United States, clinicians find themselves on the front lines of this epidemic. State-operated prescription drug monitoring programs are a valuable resource that prescribers can use to see patients' controlled substance history. Despite some limitations, these programs have been shown to be an effective method in reducing overdose deaths and the supply of controlled substances in the community.
Adjuvant steroid therapy in community-acquired pneumonia
Authors: Sisson Caroline Bell 
Published: June 2017

ABSTRACT
Despite medical advances, pneumonia is a leading cause of death worldwide. Because inflammation is a key defense mechanism, adjuvant corticosteroid therapy has long been considered but never widely recommended to treat pneumonia. New research is exploring potential benefits of this therapy, including reduced time to clinical stability, reduced hospital stay, reduced rates of treatment failure, and prevention of complications.
CaMKII Activation Promotes Cardiac Electrical Remodeling and Increases the Susceptibility to Arrhythmia Induction in High-fat Diet–Fed Mice With Hyperlipidemia Conditions
Authors: Zhong Peng , Quan Dajun , Huang Yan , Huang He 
Published: June 2017

Background:
Obesity/hyperlipidemia is closely related to both atrial and ventricular arrhythmias. CaMKII, a multifunctional serine/threonine kinase, has been involved in cardiac arrhythmias of different etiologies. However, its role in obesity/hyperlipidemia-related cardiac arrhythmia is unexplored. The aim of this was to determine the involvement of CaMKII in the process.

Methods:
Adult male APOE−/− mice were fed a high-fat diet (HFD), administrated with KN93 (10 mg·kg−1·2d−1), a specific inhibitor of CaMKII. Serum lipid and glucose profile, cardiac function, and surface electrocardiogram were determined. Electrophysiological study and epicardial activation mapping were performed in Langendorff-perfused heart. Expression of cardiac ion channels, gap junction proteins, Ca2+ handling proteins, and CaMKII were evaluated, coupled with histological analysis.

Results:
A hyperlipidemia condition was induced by HFD in the APOE−/− mice, which was associated with increased expression and activity of CaMKII in the hearts. In Langendorff-perfused hearts, HFD-induced heart showed increased arrhythmia inducibility, prolonged action potential duration, and decreased action potential duration alternans thresholds, coupled with slow ventricular conduction, connexin-43 upregulation, and interstitial fibrosis. Downregulation of ion channels including Cav1.2 and Kv4.2/Kv4.3 and disturbed Ca2+ handling proteins were also observed in HFD-induced heart. Interestingly, all these alterations were significantly inhibited by KN93 treatment.

Conclusion:
Our results demonstrated an adverse effect of metabolic components on cardiac electrophysiology and implicated an important role of CaMKII underlying this process.
A Microbiological and Ultrastructural Comparison of Aseptic versus Sterile Acellular Dermal Matrix as a Reconstructive Material and a Scaffold for Stem Cell Ingrowth
Authors: Mendenhall Shaun D. , Schmucker Ryan W. , Daugherty Timothy H. F. , Kottwitz Katherine M. , Reichensperger Joel D. , Koirala Janak , Cederna Paul S. , Neumeister Michael W. 
Published: June 2017

Background:
Recent data suggest an increased risk for infection when acellular dermal matrix is used in breast reconstruction. This may be because some acellular dermal matrices are actually not terminally sterilized but are instead “aseptically processed.” This study evaluates aseptic and sterile matrices for evidence of bacterial contamination and whether or not terminal sterilization affects matrix collagen architecture and stem cell ingrowth.

Methods:
Five separate samples of 14 different matrices were analyzed by fluorescent in situ hybridization using a bacterial DNA probe to detect bacterial DNA on the matrices. Separate samples were incubated for bacteria, acid-fast bacilli, and fungi for 2 to 6 weeks to detect living organisms. The impact of terminal sterilization on the collagen network and stem cell ingrowth on the matrices was then assessed.

Results:
Traces of bacterial DNA were encountered on all matrices, with more bacteria in the aseptic group compared with the sterile group (3.4 versus 1.6; p = 0.003). The number of positive cultures was the same between groups (3.8 percent). Electron microscopy demonstrated decreased collagen organization in the sterile group. Stem cell seeding on the matrices displayed a wide variation of cellular ingrowth between matrices, with no difference between aseptic and sterile groups (p = 0.2).

Conclusions:
Although there was more evidence of prior bacterial contamination on aseptically processed matrices compared with sterile matrices; clinical cultures did not differ between groups. Terminal sterilization does not appear to affect stem cell ingrowth but may come at the cost of damaging the collagen network.

CLINICAL QUESTION/LEVEL OF EVIDENCE:
Therapeutic, V.
Is Maintenance Electroconvulsive Therapy Always an Elective Procedure?
Authors: Rosenthal Isobel A. , Kellner Charles H. 
Published: June 2017

Abstract
Because of the severe nature of psychiatric illness, electroconvulsive therapy (ECT) is not always an “elective procedure.” The pre-ECT medical evaluation, although important, should not be an impediment to timely ECT. We argue that an arbitrary regulation requiring new assessments every 30 days may be unduly burdensome and unnecessary. The small medical risk of treatment should be weighed against the potential psychiatric risk (including suicide) of delayed treatment.
MELD: Mixed Effects for Large Datasets
Authors: Nielson Dylan M. , Sederberg Per B. 
Published: June 2017

AbstractMixed effects models provide significant advantages in sensitivity and flexibility over typical statistical approaches to neural data analysis, but mass univariate application of mixed effects models to large neural datasets is computationally intensive. Threshold free cluster enhancement also provides a significant increase in sensitivity, but requires computationally-intensive permutation-based significance testing. Not surprisingly, the combination of mixed effects models with threshold free cluster enhancement and nonparametric permutation-based significance testing is currently completely impractical. With mixed effects for large datasets (MELD) we circumvent this impasse by means of a singular value decomposition to reduce the dimensionality of neural data while maximizing signal. Singular value decompositions become unstable when there are large numbers of noise features, so we precede it with a bootstrap-based feature selection step employing threshold free cluster enhancement to identify stable features across subjects. By projecting the dependent data into the reduced space of the singular value decomposition we gain the power of a multivariate approach and we can greatly reduce the number of mixed effects models that need to be run, making it feasible to use permutation testing to determine feature level significance. Due to these innovations, MELD is much faster than an element-wise mixed effects analysis, and on simulated data MELD was more sensitive than standard techniques, such as element-wise t-tests combined with threshold-free cluster enhancement. When evaluated on an EEG dataset, MELD identified more significant features than the t-tests with threshold free cluster enhancement in a comparable amount of time.
Following Snowden: an international survey
Authors: Adams Andrew A. , Murata Kiyoshi , Lara Palma Ana María 
Published: June 2017

Purpose
This paper aims to present the baseline English survey used in the other papers in this special issue.

Design/methodology/approach
The survey includes yes/no, Likert scale and free text responses, which were analysed quantitatively and qualitatively.

Findings
Respondents to the survey expressed divergent views of whether they would emulate Snowden, even though most in all countries believed he had helped rather than harmed society.

Originality/value
This is the only such broad survey on attitudes to Snowden of which the authors are aware.
Few youngsters would follow Snowden’s lead in Japan
Authors: Murata Kiyoshi , Fukuta Yasunori , Orito Yohko , Adams Andrew A. 
Published: June 2017

PurposeThis paper aims to deal with the attitudes towards and social impact of Edward Snowden’s revelations in Japan, taking the Japanese socio-cultural and political environment surrounding privacy and state surveillance into account.Design/methodology/approachA questionnaire survey of 1,820 university students and semi-structured follow-up interviews with 56 respondents were conducted, in addition to reviews of the literature on privacy and state surveillance in Japan. The outcomes of the survey were statistically analysed, and qualitative analyses of the interview results were also performed.FindingsSnowden’s revelations have had little influence over Japanese youngsters’ attitudes towards privacy and state surveillance, mainly due to their low level of awareness of the revelations and high level of confidence in government agencies.Practical implicationsThe study results imply a need for reviewing educational programmes for civic education in lower and upper secondary education.Social implicationsThe results of this study based on a large-scale questionnaire survey indicate an urgent necessity for providing Japanese youngsters with opportunities to learn more about privacy, liberty, individual autonomy and national security.Originality/valueThis study is the first attempt to investigate the social impact of Snowden’s revelations on Japanese youngsters’ attitudes towards privacy and state surveillance as part of cross-cultural analyses between eight countries.
Surveillance following Snowden: a major challenge in Spain
Authors: Adams Andrew A. , Arias-Oliva Mario , Lara Palma Ana María , Murata Kiyoshi 
Published: June 2017

Purpose
This study aims to analyse the impacts of Edward Snowden’s revelations in Spain focusing on issues of privacy and state surveillance. This research takes into consideration the Spanish context from a multidimensional perspective: social, cultural, legal and political.

Design/methodology/approach
The paper reviews the Spanish privacy and state surveillance situation. Responses to a questionnaire were collected from 207 university students studying at Universitat Rovira i Virgili or Burgos University. The quantitative responses to the survey were statistically analysed as well as qualitative considerations of free-text answers.

Findings
The survey outcomes demonstrate that a majority of respondents are aware of Snowden’s revelations, but only a few have even considered taking serious actions to improve their online privacy. One of the most relevant findings is that Spanish citizens find it acceptable to lose privacy and be subject to state surveillance if that provides a benefit in security.

Practical implications
The research points out the importance of privacy in a multicultural environment. A sensitised society is a keystone for the healthy and balanced development of state surveillance policy and practice.

Social implications
Training programmes are a critical dimension to ensure awareness across society regarding privacy and digital technologies. Suitable educational policies and curricula at all levels should be fostered.

Originality/value
Privacy and state surveillance based on information and communication technologies is an emerging research topic with important consequences for social values and ethics. This study provides an overview of Spanish higher education students’ attitudes in these areas.
Reverse logistics for the end-of-life and end-of-use products in the pharmaceutical industry: a systematic literature review
Authors: Campos Elaine Aparecida Regiani de , Paula Istefani Carisio de , Pagani Regina Negri , Guarnieri Patricia 
Published: June 2017

Purpose
The aim of this paper is to develop a systematic literature review (SLR) aiming to identify reverse logistics (RL) concepts and practices applied to the end-of-life (EOL) and end-of-use (EOU) of pharmaceuticals and to identify and synthesize, through bibliometric indicators, research opportunities on RL, considering the analysis of publications in the periodical Supply Chain Management: An International Journal (SCMij).

Design/methodology/approach
The SLR followed two steps, namely, search for articles on the subject and content analysis of selected material and bibliometric analysis of publications using VOSviewer®.

Findings
The SLR allowed the compilation of evidences regarding pharmaceutical RL in the groups: environmental risk, the RL evolution and regulatory and stakeholder’s educational perspective. Despite the timid specific literature on pharmaceutical RL, it was also possible to point out research gaps and opportunities. Pharmaceutical RL seems to be influenced by studies from traditional RL including mathematical modeling, managerial strategies and technologies but prescind of a systemic solution. Besides reducing environmental impact, the motivation to implement pharmaceutical RL resides in its potential for revenue. Considering integrated logistics as a trend and an emerging issue, RL for the pharmaceutical industry needs to be addressed more thorough and broadly.

Research limitations/implications
The limited number of papers returned in this SLR of pharmaceutical RL impaired the bibliometric analysis of them, leading to the inclusion of papers on general RL.

Originality/value
This study provides an overview of the evolution of RL in the pharmaceutical industry, it also clarifies concepts and EOL/EOU practices, particularly directed to the pharmaceutical industry RL.
Towards a classification of supply chain relationships: a routine based perspective
Authors: Ahmed Muhammad Usman , Kristal Mehmet Murat , Pagell Mark , Gattiker Thomas F. 
Published: June 2017

PurposeThis paper studies buyer–supplier relationships (BSRs) by taking a routine-based approach and develops a taxonomy of BSRs. Recent advances in the BSR literature have shown that firms implement a host of diverse routines, called integrative practices, with their supply chain partners. Relationships differ based on what integrative practices are present in them. This paper aims to develop a taxonomy of supply chain relationships based on integrative practices measured at the relationship level.Design/methodology/approachThe authors use survey data collected from North American manufacturers to establish the measurement properties of new relationship level constructs that represent different aspects of integration. Cluster analysis is used with these new constructs to develop a taxonomy of supply chain relationships. Regression and bootstrapping techniques are used to establish the predictive validity and stability of the taxonomy.FindingsThe results show four distinct types of relationships. On comparison, the authors find salient differences between their results and past classifications. As a result of taking a routine-based multidimensional view of integration, the authors find two types of relationships that have not been discovered by past taxonomies.Originality/valueThe new relationship level constructs will allow academics to have greater precision in their research questions on BSRs, as not all aspects of integration behave in the same manner. The four types of relationships identified by this study provide a useful framework to manage supply chain relationships for practitioners.
Variation in leaf anatomical traits from tropical to cold‐temperate forests and linkage to ecosystem functions
Authors: He Nianpeng , Liu Congcong , Tian Miao , Li Meiling , Yang Hao , Yu Guirui , Guo Dali , Smith Melinda D. , Yu Qiang , Hou Jihua 
Published: June 2017

Abstract

Leaf anatomical traits may reflect plants adaption to environmental changes and influence ecosystem functions, as they regulate light absorption and gas exchange to some extent. Here, we hypothesized that leaf anatomical traits were closely related to gross primary productivity (GPP) because photosynthesis commonly occurs in the chloroplasts of palisade and spongy tissues in leaf.

Eight leaf anatomical traits were measured in 916 plant species inhabiting from tropical to cold‐temperate forests in eastern China: adaxial epidermis thickness (AD), abaxial epidermis thickness (AB), leaf thickness (LT), palisade tissue thickness (PT), and spongy tissue thickness (ST), palisade–spongy tissue ratio (PT/ST), palisade tissue–leaf thickness ratio (PT/LT), and spongy tissue–leaf thickness ratio (ST/LT).

Leaf anatomical traits showed significant latitudinal patterns at species, plant functional group (PFG), and community levels (p < .05), and they differed between PFG and community. Temperature and precipitation were the main factors influencing AD, AB, PT/ST, and PT/LT, explaining 33–72% of the total variation at large scale. Furthermore, AB, LT, PT/ST, and PT/LT were significantly correlated with the aridity index.

Our findings filled the data gap of plant anatomical traits at regional scales, and broadened current knowledge on the adaptation strategies of plant anatomical traits, which also provided new evidence for linkages of plant traits and functioning across natural communities.

A plain language summary is available for this article.
Percentage arterial enhancement: An objective index for accurate identification of parathyroid adenoma/hyperplasia in primary hyperparathyroidism
Authors: Goroshi Manjunath , Lila Anurag R. , Jadhav Swati S. , Sonawane Sushil , Hira Priya , Goroshi Shetteppa , Garle Mahadev N. , Dalvi Abhay , Sathe Pragati , Bandgar Tushar R. , Shah Nalini S. 
Published: June 2017

SummaryBackgroundRadiation exposure to neck by four‐dimensional computerized tomography (4DCT) is relatively high and limits its use as a first‐line investigation in evaluation of primary hyperparathyroidism (PHPT). Radiation exposure can be reduced by restricting the number of CT phases. Our aim was to study the performance of 4DCT in cohort of surgery‐naïve PHPT patients, and to evaluate percentage enhancement as an objective radiological index to discriminate parathyroid lesions (adenoma/hyperplasia) from thyroid tissue and lymph nodes.Materials and methodRetrospective study of 49 PHPT patients {(44 single‐gland diseases (SGD) and five multiple‐gland disease (MGD)} who underwent 4DCT (unenhanced, early arterial, early venous and delayed venous phase) pre‐operatively. Two radiologists who were blinded to surgical location of parathyroid lesions examined the scans. Attenuation values were recorded for parathyroid lesions (n=50), thyroid gland (n=50) and lymph nodes (n=12) in different phases. Percentage enhancement for different phases was calculated as “(HU in a specific enhanced phase‐HU in unenhanced phase)/HU in unenhanced phase” ×100.ResultsInter‐rater reliability between the two radiologists was 0.83 (Cohen's kappa). In SGD, sensitivity and PPV were 93.18% and 98.8% for lateralization, and 89.77% and 95.18% for quadrant localization, respectively. In MGD, 4DCT showed 50% sensitivity and 100% PPV. Percentage arterial enhancement showed highest area under curve (AUC=0.992) for differentiation of parathyroid lesions from thyroid tissue and lymph nodes. A cut‐off value of 128.9% showed 95.8% sensitivity and 100% specificity for the identification of parathyroid lesions.ConclusionsWe propose that percentage arterial enhancement can be used as an objective radiological index for accurate identification of parathyroid adenoma/hyperplasia.
Enhanced Visualization of Detected 3D Geometric Differences
Authors: Palma Gianpaolo , Sabbadin Manuele , Corsini Massimiliano , Cignoni Paolo 
Published: June 2017

AbstractThe wide availability of 3D acquisition devices makes viable their use for shape monitoring. The current techniques for the analysis of time‐varying data can efficiently detect actual significant geometric changes and rule out differences due to irrelevant variations (such as sampling, lighting and coverage). On the other hand, the effective visualization of such detected changes can be challenging when we want to show at the same time the original appearance of the 3D model. In this paper, we propose a dynamic technique for the effective visualization of detected differences between two 3D scenes. The presented approach, while retaining the original appearance, allows the user to switch between the two models in a way that enhances the geometric differences that have been detected as significant. Additionally, the same technique is able to visually hides the other negligible, yet visible, variations. The main idea is to use two distinct screen space time‐based interpolation functions for the significant 3D differences and for the small variations to hide. We have validated the proposed approach in a user study on a different class of datasets, proving the objective and subjective effectiveness of the method.
Early clearance vs persistence of de novo donor‐specific antibodies following lung transplantation
Authors: Islam Ana K. , Sinha Neeraj , DeVos Jennifer M. , Kaleekal Thomas S. , Jyothula Soma S. , Teeter Larry D. , Nguyen Duc T. M. , Eagar Todd N. , Moore Linda W. , Puppala Mamta , Wong Stephen T. C. , Knight Richard J. , Frost Adaani E. , Graviss Edward A. , Osama Gaber A. 
Published: June 2017

AbstractBackgroundThe natural history of de novo donor‐specific antibodies (dnDSA) after lung transplantation is not well‐described. We sought to determine the incidence and risk factors associated with dnDSA and compare outcomes between recipients with transient (or isolated) vs persistent dnDSA after transplantation.MethodsA single‐center review of all lung transplants from 1/2009‐7/2013. DSAs were tested eight times in the first year and every 4 months thereafter. Outcomes examined included acute rejection and graft failure.ResultsMedian follow‐up was 18 months (range: 1‐61 months), and 24.6% of 333 first‐time lung‐only transplant recipients developed a dnDSA. Ethnicity, HLA‐DQ mismatches, post‐transplantation platelet transfusion and Lung Allocation Score >60 were associated with dnDSA (P<.05). Overall graft survival was worse for dnDSA‐positive vs negative recipients (P=.025). Of 323 recipients with 1‐year follow‐up, 72 (22.2%) developed dnDSA, and in 25 (34.7%), the dnDSA was transient and cleared. Recipients with transient dnDSA were less likely to develop acute rejection than those with persistent dnDSA (P=.007).ConclusionsEarly post‐lung transplantation, dnDSA occurred in 1/4 of recipients, was associated with peri‐transplant risk factors and resulted in decreased survival. Spontaneous clearance of dnDSA, seen in one‐third of recipients, was associated with a lower risk of acute rejection.