bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le savoir-faire des professionnel.le.s de la modération dans les bus nocturnes genevois
Authors: Krummenacher Leititia 
Published: November 2016

D’un projet issu d’une « mobilisation communautaire », l’association Noctambus, gérant un réseau de bus nocturnes à Genève, est devenu en vingt ans une institution à analyser selon nous dans une « perspective étatique » (Parazelli, 2004). Ce qui pose la question de la place des passager.ère.s dans cette association et plus précisément de leur participation. Bien que les passager.ère.s ne participent pas aux décisions prises par l’association, notre analyse pragmatiste du savoir-faire des modératrices et modérateurs, employé.e.s par Noctambus, démontre que, dans la pratique, la modération exige une certaine participation des passager.ère.s, sans laquelle la mission des professionnel.le.s ne pourrait pas être remplie.
Hundred-picosecond narrowband chirped-pulse generation in an Yb:YAG regenerative amplifier using transmission gratings
Authors: Hwang SungIn , Tokita Shigeki , Kawashima Toshiyuki , Nishioka Hajime , Kawanaka Junji 
Published: November 2016

Abstract
We have demonstrated a seed source for an optical parametric chirped pulse amplification pumping source through a cryogenically cooled Yb:YAG regenerative amplifier, which can vary the pulse duration depending on the number of passes and generate a very high chirp rate. The Fourier-transform-limited pulse duration of 10 ps was extended to a few hundred picoseconds (109 to 165 ps) to prevent damage to the gain medium in the subsequent high-pulse-energy pumping source, which was seeded by the regenerative amplifier. This was achieved by inserting a transmission diffraction grating pair inside the cavity of the regenerative amplifier. The variable pulse duration could be set between 109 and 165 ps by electronically adjusting the pass number of pulses inside the cavity. The stretched pulse duration and the spectral width as functions of the pass number were characterized by considering the dispersion from the grating stretcher as well as the gain narrowing effect.
High-density formation of Ta nanodot induced by remote hydrogen plasma
Authors: Wang Yaping , Takeuchi Daichi , Ohta Akio , Ikeda Mitsuhisa , Makihara Katsunori , Miyazaki Seiichi 
Published: November 2016

Abstract
We have studied the formation of Ta nanodots (NDs) on thermally grown SiO2/Si by exposing a thin metal layer to a remote H2 plasma (H2-RP) without external heating. Atomic force microscopy (AFM) analyses show that a combination of a Ge (∼30.0 nm)/Ta (∼2.0 nm) bilayer stack with subsequent H2-RP exposure is effective for forming electrically isolated Ta NDs with an areal dot density as high as ∼1011 cm−2, where the Ge layer plays an important role as a barrier layer against the oxidation of the ultrathin Ta layer surface. The change in the chemical structure of the Ge/Ta bilayer stack on SiO2/Si upon Ta ND formation by H2-RP exposure is investigated by hard X-ray photoemission spectroscopy (HAXPES) and X-ray photoelectron spectroscopy (XPS).
Site‐Selective Iron(III) Chloride‐Catalyzed Arylation of 4‐Aryl‐4‐methoxy‐2,5‐cyclohexadienones for the Synthesis of Polyarylated Phenols
Authors: Sawama Yoshinari , Masuda Masahiro , Nakatani Ryosuke , Yokoyama Hiroki , Monguchi Yasunari , Dohi Toshifumi , Kita Yasuyuki , Sajiki Hironao 
Published: November 2016

AbstractThe iron(III) chloride‐catalyzed Friedel–Crafts arylation of 4‐aryl‐4‐methoxy‐2,5‐cyclohexadienones, which were easily prepared by the phenyliodine(III) diacetate (PIDA)‐mediated oxidation of 4‐arylphenols in methanol, proceeded site‐selectively to form meta‐terphenyl (2,4‐diarylphenol) derivatives in good yields. The subsequent PIDA‐mediated oxidation and iron(III) chloride‐catalyzed Friedel–Crafts arylation of the resulting products gave the corresponding 2,4,6‐triarylphenol derivatives. The present method provides useful highly substituted polyarylated compounds.magnified image
Bioreduction of α‐Acetoxymethyl Enones: Proposal for an SN2′ Mechanism Catalyzed by Enereductase
Authors: Paula Bruno R. S. , Zampieri Davila , Rodrigues J. Augusto R. , Moran Paulo J. S. 
Published: November 2016

Abstract(Z)‐3‐Acetoxymethyl‐4‐R‐3‐buten‐2‐ones (R=aryl, alkyl) and (Z)‐3‐methyl‐4‐R‐3‐buten‐2‐ones (R=aryl) were synthesized and submitted to reduction by the yeast Saccharomyces cerevisiae producing the (R)‐ and (S)‐4‐R‐3‐methybutan‐2‐ones, respectively. This stereochemistry control strategy was applied in the syntheses of (R)‐ and (S)‐Tropional® with moderate to high enantiomeric excesses. Other (Z)‐3‐acyloxymethyl‐4‐phenyl‐3‐buten‐2‐ones showed similar behavior to the (Z)‐3‐acetoxymethyl counterpart, and the acylated Morita–Baylis–Hillman adduct 1‐acetoxy‐2‐methylene‐1‐phenylbutan‐3‐one produced a mixture of products, with and without the acetoxy group, via three different reaction pathways. In addition to experiments employing whole cells, those in which isolated enereductases were used suggested that the main pathway through which the loss of the acetoxy group occurs during the biocatalytic cascade is an SN2′‐type reaction, rather than formal hydrogen addition followed by acetic acid elimination. Finally, related ethyl enones were reduced enantioselectively by the yeast Candida albicans, producing both (R)‐ and (S)‐reduction products, depending on the presence of the acetoxy group in the starting material.magnified image
Nickel‐Catalyzed C–H Trifluoromethylation of Electron‐Rich Heteroarenes
Authors: Wu Yun , Zhang Hao‐Ran , Jin Ruo‐Xing , Lan Quan , Wang Xi‐Sheng 
Published: November 2016

AbstractThe first example of a nickel‐catalyzed C–H trifluoromethylation of electron‐rich heteroarenes, including imidazopyridines, indoles and thiophenes, has been developed with the commercially available and relatively inexpensive industrial raw material iodotrifluoromethane (CF3I) as the trifluoromethylating reagent. The synthetic potential of this method is demonstrated by its successful application to the direct trifluoromethylation of the biologically active molecules melatonin and zolmitriptan.magnified image
Synthesis and study on the binding of thiazol‐2(3H)‐ylidine derivative with human serum albumin using spectroscopic and molecular docking methods
Authors: Hassan Mohammad Fahimul , Rauf Abdul 
Published: November 2016

AbstractIn this article, a facile and convenient synthesis of thiazol‐2(3H)‐ylidine derivatives of fatty acid (3a–c) is described. The binding of N′‐(4,5‐dimethyl‐3‐penylthiazol‐2(3H)‐ylidine)octadec‐9‐enehydrazide (3a) with human serum albumin (HSA) is explored using various spectral methods and molecular docking. Fluorescence quenching results show that 3a induces conformational changes in HSA and the polarity around the tryptophan residues is increased. Stern–Volmer quenching plots at different temperatures (298, 305 and 312 K) show that the fluorescence quenching mechanism is static quenching. Synchronous fluorescence, 3D fluorescence spectra, circular dichroism and Fourier transform infrared spectroscopy are used to determine the structural change in HSA on interaction with 3a. Förster resonance energy transfer analysis shows that the binding distance (r0 = 2.78 nm) between HSA (Trp214) and 3a is within the of range 2–8 nm for quenching to occur. The molecular docking study also confirms that 3a is located in subdomain IIA (site I) of HSA and is stabilized by hydrogen bonding and hydrophobic forces.
Characterization of Different Conductive Salts in ACN‐Based Electrolytes for Electrochemical Double‐Layer Capacitors
Authors: Krummacher Jakob , Schütter Christoph , Passerini Stefano , Balducci Andrea 
Published: November 2016

AbstractHerein we report a systematic investigation of the chemical and physical properties of acetonitrile‐based electrolytes that contained the salts tetraethylammonium tetrafluroroborate (Et4NBF4), tetraethylammonium bis(trifluoromethanesulfonyl)‐ imide (Et4NTFSI), 1‐butyl‐1‐methylpyrrolidinium tetrafluoroborate (Pyr14BF4), or 1‐butyl‐1‐methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (Pyr14TFSI). The ionic conductivity, viscosity, density, and electrochemical stability windows of these electrolytic solutions have been considered in detail. From these results, the electrolyte Et4NTFSI (1 mol dm−3) in ACN appeared to display a promising set of properties that allow the realization of ACN‐based electrochemical double‐layer capacitors able to display stable behavior at 3.1 V.
Validation of a non‐conforming monolithic fluid‐structure interaction method using phase‐contrast MRI
Authors: Hessenthaler Andreas , Röhrle Oliver , Nordsletten David 
Published: November 2016

AbstractThis paper details the validation of a non‐conforming arbitrary Lagrangian‐Eulerian fluid‐structure interaction technique using a recently developed experimental 3D fluid‐structure interaction benchmark problem. Numerical experiments for steady and transient test cases of the benchmark were conducted employing an inf‐sup stable and a general Galerkin scheme. The performance of both schemes is assessed. Spatial refinement with three mesh refinement levels and fluid domain truncation with two fluid domain lengths are studied as well as employing a sequence of increasing time step sizes for steady‐state cases. How quickly an approximate steady‐state or periodic steady‐state is reached is investigated and quantified based on error norm computations. Comparison of numerical results with experimental phase‐contrast magnetic resonance imaging data shows very good overall agreement including governing of flow patterns observed in the experiment.
Cloud‐aided scalable revocable identity‐based encryption scheme with ciphertext update
Authors: Wang Changji , Li Yuan , Fang Jian , Xie Jianguo 
Published: November 2016

SummaryKey revocation and ciphertext update are two critical issues for identity‐based encryption schemes. Designing an identity‐based encryption scheme with key revocation and ciphertext update functionalities simultaneously is still a tricky challenge. Recently, Liang et al. introduce the notion of cloud‐based revocable identity‐based proxy re‐encryption scheme and present a concrete scheme with aim to solve the challenge. In this paper, we first showed the scheme of Liang et al. cannot resist re‐encryption key forgery attack and collusion attack. We then introduced a new cryptographic primitive, named cloud‐aided revocable identity‐based encryption scheme with ciphertext update (CA‐RIBE‐CU), to achieve both ciphertext update and key revocation for identity‐based encryption schemes. We also defined the syntax and security model of CA‐RIBE‐CU scheme and proposed a CA‐RIBE‐CU scheme from bilinear pairings. Compared with the scheme of Liang et al., our proposed scheme is collusion resistant, takes lower decryption computation, and achieves constant size re‐encrypted ciphertext. Finally, we proved the proposed scheme is adaptively secure under the decisional bilinear Diffie–Hellman assumption in the standard model. Copyright © 2016 John Wiley & Sons, Ltd.
Explaining the Cyclic Voltammetry of a Poly(1,4‐phenylene‐ethynylene)‐alt‐poly(1,4‐phenylene‐vinylene) Copolymer upon Oxidation by using Spectroscopic Techniques
Authors: Enengl Christina , Enengl Sandra , Bouguerra Nassima , Havlicek Marek , Neugebauer Helmut , Egbe Daniel A. M. 
Published: November 2016

AbstractPoly(1,4‐phenylene‐ethynylene)‐alt‐poly(1,4‐phenylene‐vinylene) (PPE‐PPV) copolymers have attracted quite a lot of attention in the last few years for electronic device applications owing to their enhanced fluorescence. In this work, we focus on one particular PPE‐PPV copolymer with dissymmetrically substituted 1,4‐phenylene‐ethynylene and symmetrically substituted 1,4‐phenylene‐vinylene building units. Six successively performed cyclic voltammograms are presented, measured during the oxidation reactions. As the oxidation onset of the electrochemical reaction shifts to lower potentials in each cycle, this behavior is elucidated by using spectroscopic techniques ranging from UV/Vis/near‐IR to mid‐IR including spin‐resonance techniques. Hence, these findings help to explain some of the copolymer's most advantageous properties in terms of possible oxidation products.
Psychotropic Drug Development Strategies that Target Neuropsychiatric Etiologies in Alzheimer's and Parkinson's Diseases
Authors: Van der Schyf Cornelis J. 
Published: November 2016

ABSTRACT

Preclinical Research

Neuropsychiatric symptoms are currently recognized as a common burden in patients suffering from Alzheimer's disease (AD), Parkinson's disease (PD), and many other neurodegenerative disorders. Earlier theories positing that these symptoms emerge predominantly in patients with late‐stage disease have been largely dismissed. It is now generally accepted that many neuropsychiatric symptoms commonly manifest very early in neurodegenerative disease stages, and in many cases are even considered prodromal indicators. Despite intense research efforts, no reliable drug treatment strategies have been found for the neuropsychiatric symptoms associated with AD and PD. Among the medications commonly used at this stage, many present significant risks for patients in this particular cohort. Transcriptomic tools and proteomic profiling have clearly indicated that neurodegenerative diseases and their associated neuropsychiatric comorbidities are multifactorial in origin. As such, multiple—and in many cases divergent—disease etiologies lead to the neuropsychiatric symptoms associated with AD, PD, and other neurodegenerative disorders. The complexity of these pathways (initiated by a cascade of molecular events that involve several neurotransmitter systems) offer significant challenges to drug discovery efforts aimed at addressing these symptoms. In response to this complexity, a new paradigm has emerged that challenges the widely held assumption that “targeted” drug design is superior to the development of “multi‐targeted” drugs as a strategy to address the neuropsychiatric symptoms associated with AD and PD. In this Overview, I offer an overview of drug discovery strategies and investigative drugs currently under development that address multiple CNS etiological targets associated with an array of neuropsychiatric symptoms. Drug Dev Res 77 : 458–468, 2016. © 2016 Wiley Periodicals, Inc.
Metabolic support for the heart: complementary therapy for heart failure?
Authors: Heggermont Ward A. , Papageorgiou Anna‐Pia , Heymans Stephane , van Bilsen Marc 
Published: November 2016

AbstractThe failing heart has an increased metabolic demand and at the same time suffers from impaired energy efficiency, which is a detrimental combination. Therefore, therapies targeting the energy‐deprived failing heart and rewiring cardiac metabolism are of great potential, but are lacking in daily clinical practice. Metabolic impairment in heart failure patients has been well characterized for patients with reduced ejection fraction, and is coming of age in patients with ‘preserved’ ejection fraction. Targeting cardiomyocyte metabolism in heart failure could complement current heart failure treatments that do improve cardiovascular haemodynamics, but not the energetic status of the heart. In this review, we discuss the hallmarks of normal cardiac metabolism, typical metabolic disturbances in heart failure, and past and present therapeutic targets that impact on cardiac metabolism.
Stochastic geometry model to analyze 5G energy efficiency based on a novel dynamic spectrum access scheme
Authors: Bohli Afef , Bouallegue Ridha 
Published: November 2016

ABSTRACTThe communication network has to undergo a significant change to be able to keep up with the exponential demand for mobile data. The next 5G mobile generation, based essentially on the heterogeneous network architecture—a macro tier overlayed with unplanned small cell tiers—is defined as a promising solution to meet those needs. Despite the considerable increase in data rates through the small cell concept and the shared spectrum access, the most crucial challenge is the interference management issue. To overcome this limitation and establish an economical and ecological design, the need for new spectrum management concepts is triggered. Unlike the classical cell association scheme, which requires cell tier cooperations, the contribution of this paper is to conceive an efficient cell association scheme in a non coordination 5G heterogeneous network architecture, based on a novel dynamic spectrum access (DSA) approach. The suggested DSA is based on the dynamic common cognitive monitor channel—with a cognitive monitor strategy using the maximum holding time distribution—and the highest signal‐to‐interference‐plus‐noise ratio–based cell association. The coverage probability and the throughput for a typical user in a two‐tier heterogeneous network (macro and small cell tiers) as well as the analytical expression of the energy efficiency are derived and analyzed using a stochastic geometry system model. The performance of the suggested DSA scheme is quantified and highlighted through detailed simulations and numerical results.
Establishment and characterization of a novel Hodgkin lymphoma cell line, AM‐HLH, carrying the Epstein‐Barr virus genome integrated into the host chromosome
Authors: Hayashida Masahiko , Daibata Masanori , Tagami Erika , Taguchi Takahiro , Maekawa Fumiyo , Takeoka Kayo , Fukutsuka Katsuhiro , Shimomura Daiki , Hayashi Takamasa , Iwatani Yoshinori , Ohno Hitoshi 
Published: November 2016

AbstractWe describe the establishment and characterization of a cell line, AM‐HLH, obtained from a patient with Epstein‐Barr virus–positive (EBV+) nodular sclerosis–type Hodgkin lymphoma (HL). The cells were positive for CD2 and CD30 and negative for CD15. The immunoglobulin heavy‐ and κ light–chain genes were rearranged. The karyotype was of the triploid range. Southern blotting using the EBV terminal repeat probe detected 3 hybridizing bands that were identical to those of the parental HL material. The cells expressed EBV‐encoded RNAs as well as latent genes (EBNA1, EBNA2, LMP1, and LMP2A) and lytic genes (BZLF1 and BALF2). Fluorescence in situ hybridization (FISH) with the cosmid pJB8 clone containing a fragment of EBV DNA as a probe revealed multiple hybridization signals at a marker chromosome. Additional FISH using whole chromosome painting and centromere probes in combination with multicolor FISH determined that multiple EBV copies were clustered within the chromosome 20 materials of the marker chromosome. Culture supernatants of AM‐HLH contained IL‐10 as measured by the bead‐based immunoassay. It is possible that an integrated EBV genome and cellular genes on chromosome 20 were coamplified, leading to the enhanced expression of genes involved in cell growth control. The AM‐HLH cell line will be useful to clarify the role of cytokines in the development of EBV+ HL.
Oxygenation dynamics of sepsis patients undergoing far‐infrared intervention based on near‐infrared spectroscopy
Authors: Chuang Kuei‐Hung , Chuang Ming‐Lung , Sia Sung‐kien , Sun Chia‐Wei 
Published: November 2016

Near‐infrared spectroscopy (NIRS; continuous wave type) is a noninvasive tool for detecting the relative change of oxyhemoglobin and deoxyhemoglobin. To make this change, intervention methods must be applied. This study determined the hemodynamics of 44 healthy participants and 35 patients with sepsis during exposure to FIR as a novel physical intervention approach. Local microcirculation of their brachioradialis was monitored during exposure and recovery through NIRS. The variations in blood flow and microvascular reaction were determined by conducting paired and unpaired t tests. The oxyhemoglobin levels of the healthy participants increased continuously, even during recovery. In contrast to expextations, the oxyhemoglobin levels of the patients plateaued after only 5 min of FIR illumination. The proposed method has potential applications for ensuring efficient treatment and facilitating doctors in diagnosing the functions of vessels in intensive care units.
Mapping diagrams of HbO2 in healthy males and males with sepsis illustrated unique scenarios during the process.magnified imageMapping diagrams of HbO2 in healthy males and males with sepsis illustrated unique scenarios during the process.
Therapeutic Potential of Small Molecule Inhibitors
Authors: Khera Nimmish , Rajput Sandeep 
Published: November 2016

ABSTRACTWithin the last two decades, the advancement in cellular and cancer biology research can be defined by a few foundational pillars—one of the most important ones being the advent of small‐molecule inhibitors (SMIs). Due to their several advantages over contemporary cytotoxic drugs, these engineered molecules have not only shed light on a much deeper understanding of the cellular microenvironment and signal transduction pathways, they have also provided hope of achieving clinical benefits of better patient tolerability while surpassing the efficacy of chemotherapeutic agents. It is, therefore, no surprise that research and development of SMIs has witness a steady surge amongst pharmaceutical industries and research institutions. It is, however, safe to assume that the current applications of SMIs are the mere tip of a yet‐inconceivable iceberg. J. Cell. Biochem. 118: 959–961, 2017. © 2016 Wiley Periodicals, Inc.
Isolated intrasplenic vascular calcifications in a child with type 1 diabetes mellitus‐‐‐A case report
Authors: Patil Parag V. , Patil Manojkumar G. , Patil Abhijit M. 
Published: November 2016

ABSTRACTWe report a case of vascular calcifications in the spleen of a 7‐year‐old girl who was diagnosed with type 1 diabetes mellitus (DM). The possible etiology for vascular calcifications might be medial sclerosis associated with DM. To the best of our knowledge, this finding has not yet been reported in the literature. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45:438–440, 2017
Subcortical 18F‐AV‐1451 binding patterns in progressive supranuclear palsy
Authors: Cho Hanna , Choi Jae Yong , Hwang Mi Song , Lee Seung Ha , Ryu Young Hoon , Lee Myung Sik , Lyoo Chul Hyoung 
Published: November 2016

ABSTRACTBackgroundAccumulation of cortical and subcortical tau pathology is the primary pathological substrate for progressive supranuclear palsy (PSP). 18F‐AV‐1451, a radiotracer that binds to the pathological tau protein, may be helpful for in vivo visualization and quantitation of tau pathology in PSP.ObjectivesThe objectives of this study were to investigate cortical and subcortical 18F‐AV‐1451 binding patterns in patients with PSP.MethodsWe recruited 14 PSP patients and compared their cortical and subcortical binding patterns in 18F‐AV‐1451 positron emission tomography (PET) studies with those of 15 Parkinson's disease (PD) patients and 15 healthy controls.ResultsIn both the PD and PSP groups, subcortical 18F‐AV‐1451 binding did not correlate with the severity of motor dysfunctions, and cortical binding did not differ between the controls and each patient group. However, the PSP patients showed greater 18F‐AV‐1451 binding in the putamen, globus pallidus, subthalamic nucleus, and dentate nucleus when compared with the controls, whereas the PD patients showed lower 18F‐AV‐1451 binding in the substantia nigra than controls.ConclusionsThe PSP and PD patients showed distinct subcortical 18F‐AV‐1451 binding patterns reflecting subcortical tau pathology in PSP and reduced nigral neuromelanin in PD. However, there was no correlation with the severity of motor dysfunction, no cortical regions with increased binding in PSP patients, and variable degrees of subcortical binding even in the controls. Therefore, the 18F‐AV‐1451 PET may be less than ideal for assessing tau pathology in PSP. Further studies will be required to validate the clinical correlation and to understand the clinical utility of 18F‐AV‐1451 PET for PSP patients. © 2016 International Parkinson and Movement Disorder Society