bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis, Antioxidant Activity, and Molecular Docking of Novel Paeoniflorin Derivatives
Authors: Ni Jiating , Yang Meng , Zheng Xinyue , Wang Mingtao , Xiao Qian , Han Hua , Dong Peiliang 
Published: September 2024

ABSTRACTPaeoniflorin (PF) is one of the active constituents of the traditional Chinese medicine Paeoniae Radix Rubra and has been actively explored in the pharmaceutical area due to its numerous pharmacological effects. However, severe difficulties such as limited bioavailability and low permeability limit its utilization. Therefore, this study developed and synthesized 25 derivatives of PF, characterized them by 1H NMR, 13C NMR, and HR‐MS, and evaluated their antioxidant activity. Firstly, the antioxidant capacity of PF derivatives was investigated through DPPH radical scavenging experiment, ABTS radical scavenging experiment, reducing ability experiment, and O2.− radical scavenging experiment. PC12 cells are routinely used to evaluate the antioxidant activity of medicines, therefore we utilize it to establish a cellular model of oxidative stress. Among all derivatives, compound 22 demonstrates high DPPH radical scavenging capacity, ABTS radical scavenging ability, reduction ability, and O2.− radical scavenging ability. The results of cell tests reveal that compound 22 has a non‐toxic effect on PC12 cells and a protective effect on H2O2‐induced oxidative stress models. This might be due to the introduction of 2, 5‐difluorobenzene sulfonate group in PF, which helps in scavenging free radicals under oxidative stress. Western blot and molecular docking indicated that compound 22 may exert antioxidant activity by activating Nrf2 protein expression. As noted in the study, compound 22 has the potential to be a novel antioxidant.
Physical exercise‐induced circAnks1b upregulation promotes protective endoplasmic reticulum stress and suppresses apoptosis via miR‐130b‐5p/Pak2 signaling in an ischemic stroke model
Authors: Yang Xiaofeng , Mu Yating , Feng Yifeng , Li Mingyue , Hu Haojie , Zhang Xiaoya , Zuo Zejie , Wu Rui , Xu Jinghui , Zheng Fang , He Xiaofei , Hu Xiquan , Zhang Liying 
Published: September 2024

AbstractAimsPhysical exercise (PE) can accelerate post‐stroke recovery. This study investigated contributions of circRNAs to PE‐induced improvements in post‐stroke neurological function.MethodsRats subjected to transient middle cerebral artery occlusion were left sedentary or provided running‐wheel access for 4 weeks during recovery. CircRNAs from peri‐infarct cortex were identified by high‐throughput sequencing, and interactions with miRNAs by immunoprecipitation, fluorescence in suit hybridization, and dual‐luciferase reporter assays. In vivo circRNA knockdown was achieved using shRNA‐AAVs and in vitro overexpression by plasmid transfection. Transmission electron microscopy, western blotting, and TUNEL assays were conducted to explore circRNA contributions to endoplasmic reticulum (ER) stress and neuronal apoptosis. CircRNA levels were measured in plasma from stroke patients by qRT‐PCR and associations with neurological scores assessed by Pearson's correlation analysis.ResultsPE upregulated circAnks1b, reduced infarct volume, and mitigated neurological dysfunction, while circAnks1b knockdown exacerbated neurological dysfunction and increased infarct size despite PE. CircAnks1b sponged miR‐130b‐5p, thereby disinhibiting Pak2 expression. Conversely, Pak2 downregulation disrupted PE‐mediated protective ER stress, leading to reduced IRE1/XBP1 and heightened apoptosis. Plasma circAnks1b was higher in stroke patients receiving PE than sedentary patients and correlated negatively with neurological scores.ConclusionsCircAnks1b upregulation may be an effective therapeutic strategy for post‐stroke recovery.
Caring organizational cultures and the future of work
Authors: Saks Alan M. , Gruman Jamie A. 
Published: September 2024

AbstractThere is substantial evidence that workplaces of the future will be dominated by an increase in advanced technology. This trend might lead to the objectification and dehumanization of employees and other stakeholders who interact with organizations as impersonal operations and procedures become normative and employees are subordinated to technology. This also means that the needs of employees and other stakeholders will be changing and organizations must respond if they are to be effective and successful in the future. In this paper, we argue that in order to counteract the dehumanizing effects of technology, organizations of the future need to be more caring and this requires building a culture of care in which the organization places a high priority on the needs and well‐being of employees, managers, customers, and the community in which it operates. We provide a multiple‐stakeholder perspective of organizational care and explain how care and concern can move up, down, around, and outside organizations and the positive consequences of care for organizations and all stakeholders. The paper also offers suggestions for future research and practice on organizational care and caring organizational cultures.
Coordination contract design for a two‐echelon supply chain considering risk aversion and yield uncertainties
Authors: Cai Jianhu , Cao Zhengang , Zhang Xiaoyang , Jia Lishuang , Xu Jie 
Published: September 2024

AbstractThis study establishes a two‐echelon supply chain (SC) wherein the supplier and the manufacturer suffer from yield uncertainty, and the supplier has a risk‐averse attitude. The SC members’ optimal input quantity and order quantity are investigated. On this basis, the revenue‐sharing and subsidy contracts are introduced to achieve SC coordination. The findings indicate that the two contracts are valid on SC coordination, and there exists a one‐to‐one relationship between these two contracts. Moreover, the two contracts can achieve the same utility allocation between the SC members under specific conditions. Overall, our findings help the SC members develop more efficient cooperation mechanisms.
The Power of Calling: How Founder CEOs Drive Ambidexterity and Innovation in Firms
Authors: Pan Jingzhou , Hmieleski Keith M. , Ma Bin , Lysova Evgenia I. , Tang Ziyang , Huang Xu 
Published: September 2024

AbstractThis study investigates the phenomenon of founder CEOs playing an inordinately crucial role in achieving firm innovation performance. While existing research compares the effectiveness of founder and non‐founder CEOs, the reasons behind founder CEOs’ advantage in achieving high innovation performance remain unclear. Building on upper echelons theory, this study explores micro‐foundations underlying this phenomenon. We propose that CEO founder status positively influences innovation performance through the application of ambidextrous firm strategy, with such effects being moderated by the extent to which CEOs experience a sense of calling for their work. Based on data from 200 small‐ and medium‐sized high‐tech enterprises in China, we find that founder, as compared to non‐founder, CEOs have a more positive relationship with innovation performance, mediated by ambidextrous firm strategy, and this effect is strengthened by calling for their work. These findings provide new insights regarding how and when a ‘founder advantage’ is most likely to be achieved regarding innovation performance. Moreover, by focusing on Chinese firms, this study responds to calls for expanding management research beyond Western contexts, enriching our understanding of founder CEOs and innovation in diverse cultural settings.
IgA nephropathy: Correlation between pathologic findings and complement activation
Authors: Haas Mark 
Published: September 2024

Summary at a glanceComplement plays a vital role in the pathogenesis of IgA nephropathy. Kidney biopsies with IgA nephropathy show glomerular immune complex deposits with evidence of complement activation by the alternative pathway and in a subset of cases the mannose binding lectin pathway. The recent development of specific drugs targeting these complement pathways represent a potentially important new approach to treating IgA nephropathy.
My journey on the path to understanding IgA nephropathy: From bench to bedside
Authors: Tomino Yasuhiko 
Published: September 2024

AbstractWhen Berger et al. first reported IgA nephropathy in 1968, the prognosis was generally thought to be benign. However, as more case data were accumulated, it became evident that not all patients with IgA nephropathy necessarily had a good prognosis. IgA nephropathy has a significant morbidity, culminating in end‐stage kidney disease (ESKD) in about 40% of patients without treatment within 20 years of the diagnosis. Although almost 20% of patients remain stable in their renal function, 30%–40% of patients develop ESKD from its onset. The important factors of renal outcome in patients with IgA nephropathy is the severity of histopathological findings, heavy proteinuria, long duration of proteinuria, haematuria and hypertension.
Mucosal targeting in IgA nephropathy targeting the gut associated lymphoid tissue
Authors: Barratt Jonathan 
Published: September 2024

AbstractIgA nephropathy is a mucosally driven disease and new therapeutic approaches are specifically targeting the mucosal production of IgA in the hope that this will lead to a reduction in circulating IgA immune complexes and mesangial IgA deposition. In this lecture, I discuss the rationale for targeting the mucosal immune system of the gut and the existing data from clinical trials supporting such an approach as a disease modifying treatment for IgA nephropathy.
Ablation of Supraventricular Arrhythmias With as Low as Reasonably Achievable X‐Ray exposure (AALARA)
Authors: Amin Mohammad , Abdrakhmanov Ayan , Kropotkin Evgeniy , Traykov Vasil , Salló Zoltán , Gellér László , Lorgat Faizel , Sapelnikov Oleg , Toman Ondrej , Al‐Muti Khalid , Aljaabari Mohamed , Bystriansky Adrian , Környei László , Mujović Nebojša , Simons Stefanie , Szegedi Nándor 
Published: September 2024

ABSTRACTIntroductionThe reduction of fluoroscopic exposure during catheter ablation of supraventricular arrhythmias is widely adopted by experienced electrophysiology physicians with a relatively short learning curve and is becoming the standard of care in many parts of the world. While observational studies in the United States and some parts of Western Europe have evaluated the minimal fluoroscopic approach, there are scarce real‐world data for this technique and the generalizability of outcomes in other economic regions.MethodThe AALARA study is a prospective, observational, multicenter, and multinational open‐label study. Patients were recruited from 13 countries across Central Eastern Europe, North and South Africa, the Middle East, and the CIS (Commonwealth of Independent States), with different levels of operator expertise using minimal fluoroscopic exposure techniques. Data on radiation exposure, procedural success, complications, recurrence, and quality of life changes were collected and analyzed.ResultA total of 680 patients were enrolled and followed for 6 months. The majority were ablation naïve with the commonest arrhythmia ablated being typical AVNRT (58%) followed by Atrial Flutter (23%). Zero fluoroscopy exposure was observed in almost 90% of the cases. Fluoroscopy was most commonly used during the ablation phase of the procedure. We observed a high acute success rate (99%), a low complication rate (0.4%), and a 6‐month recurrence rate of 3.8%. There was a significant improvement in the patient's symptoms and quality of life as measured by patient global assessment.ConclusionThe routine use of a 3D mapping system during right‐sided ablation was associated with low radiation exposure and associated with high acute success rate, low complications, and recurrence rate along with significant improvement in quality of life. The data confirm the reproducibility of this approach in real‐world settings across different healthcare systems, and operator experience supporting this approach to minimize radiation exposure without compromising efficacy and safety.Trial RegistrationNCT04716270
In‐Hospital Outcomes of Ventricular Tachycardia Catheter Ablation in the Presence of Intra‐Cardiac Thrombus
Authors: Margolis Gilad , Nov Carmel , Kazatsker Mark , Kobo Ofer , Roguin Ariel , Leshem Eran 
Published: September 2024

ABSTRACTBackgroundVentricular tachycardia (VT) catheter ablation in the presence of intracardiac thrombi was evaluated in very few studies.ObjectivesTo investigate in‐hospital outcomes of VT ablation in the presence of an intracardiac thrombus, in a large inpatient US registry.MethodsUsing the National Inpatient Sample (NIS) database, patients who underwent non‐elective VT catheter ablations in the United States between 2016 and 2019 were identified using ICD‐10 codes. Sociodemographic, clinical data, in‐hospital procedures, and outcomes as well as in‐hospital mortality were collected. In‐hospital outcomes were compared using propensity score (PS) matching analysis with a 1:3 ratio between patients with and without intracardiac thrombus.ResultsA weighted total of 15,725 admissions for non‐elective VT ablation were included in the study, of which 190 (1.2%) had a discharge diagnosis of intracardiac thrombus. Patients with intracardiac thrombus had a higher comorbidity burden and were more likely to have ischemic cardiomyopathy and a diagnosis of cardiac aneurysm. In PS analysis, the presence of intracardiac thrombus was significantly associated with higher rates of any in‐hospital complications (42.1% vs. 19.3%, p < 0.009), driven by higher periprocedural cerebrovascular accident and vascular injury events. In‐hospital mortality rates were not significantly different between the groups.ConclusionsIn patients undergoing non‐elective VT ablation, intracardiac thrombus was associated with higher rates of in‐hospital complications, but not higher in‐hospital mortality. These findings suggest that intracardiac thrombus should not contraindicate VT ablation when deemed necessary, while efforts should be made to decrease potential complications.
Earning trust in intergroup contexts: The interplay of perceived warmth and competence
Authors: Wei Cong , Wu Ziyi , Dang Jianning , Liu Li 
Published: September 2024

AbstractPrevious research on intergroup trust has focused predominantly on trustors' dispositional profiles while overlooking the pivotal role of perceptions of the target outgroup and their intricate interactions. Building on the “Big‐Two” model of social perception, four studies (N = 802) examined the proposition that intergroup trust is a joint function of the target outgroup's perceived warmth and competence. Studies 1 and 2 investigated how American and Chinese people's perceptions of each other regarding warmth and competence impact their mutual trust, respectively. Study 3 manipulated social perceptions of a virtual group by presenting warmth‐ and competence‐related cues and captured the resulting intergroup trust behavior. Study 4 examined intergroup trust toward four natural groups generally perceived to have different levels of warmth and competence in both cooperative and competitive contexts. Consistent with our theoretical predictions, perceived warmth promoted intergroup trust only when the target outgroup was perceived as competent. Alternatively, the sign of perceived competence's role in predicting intergroup trust depended primarily on perceived warmth. These findings underscore the indispensability of both warmth and competence in shaping intergroup trust and have implications for international conflict resolution and peacekeeping.
How do multidimensional energy justices work?: Specifying the role of anthropocentric and ecological justice in the acceptance of solar energy
Authors: Jeon Sehyeok , Kim Seoyong , Kim Miri 
Published: September 2024

AbstractThis study analyzed the acceptance of solar energy in terms of energy justice. The critical issue of energy supply, demand, and transition is a process of social redistribution of risks from old to new energy systems. The question of the appropriate distribution of risks for the energy system is closely related to energy justice. Previous studies are limited in empirically testing whether or not energy justice can contribute to the acceptance of new energy system. In addition, previous studies have heavily depended on energy justice in terms of anthropocentric type. Anthropocentric definitions of energy justice have focused primarily on the benefits and costs allocated only to humans. Such an anthropocentric view of justice lacks consideration of the value of various ecological beings. Therefore, this study aims to shed light on the role of not only four anthropocentric types of energy justices but also on for four ecological ones in the acceptance of solar energy. The analysis reveals that recognitive justice, generational justice, deep ecological justice, social ecological justice, and distributional justice positively influence the acceptance of solar energy, whereas procedural justice, restorative justice, and eco‐socialist justice have no effect on it. In particular, this study found that recognitive justice moderates the effect of personal norms on acceptance of solar energy, whereas restorative justice moderates the effect of knowledge on it.
Governing climate change in a changing world
Authors: Westman Linda 
Published: September 2024

AbstractThis commentary reflects on a longstanding interdisciplinary exchange across geography and political science, which has crystallised into the scholarship on climate governance. This debate has fundamentally shaped ideas on how climate change can be managed as a societal challenge and with what consequences. The analysis briefly maps the emergence of climate governance as a concept and its progressive embedding in climate policy discourse. Next, the discussion reflects on how the application of associated frameworks may become increasingly ‘stretched’, as theoretical toolkits travel far beyond the settings in which they were developed.
Effects of topical 0.5% tropicamide and 1% atropine on pupil diameter, intraocular pressure, and tear production, in healthy pet rabbits
Authors: Cabrero María , Guyonnet Alexandre , Mercado Laura , Andrejak‐Benit Juliette , Meric Tristan , Bourguet Aurélie 
Published: September 2024

AbstractObjectiveTo evaluate the effects of topical application of 0.5% tropicamide and 1% atropine on pupil diameter (PD), intraocular pressure (IOP), and tear production (TP) in healthy pet rabbits.Animals StudiedTen healthy client‐owned rabbits.ProceduresA prospective, randomized, blinded, crossover study was conducted. Each animal received one drop of 0.5% tropicamide or 1% atropine in a randomly selected eye. PD, IOP, and TP were evaluated before drug instillation and at 0.25 h, 0.5 h, 0.75 h, 1 h, 2 h, 4 h, 6 h, 8 h, 10 h, 12 h, 24 h, 36 h, 48 h, 60 h, and 72 h post‐instillation. Data were analyzed using a paired two‐sample repeated measures T‐test with Bonferroni correction.ResultsIn both tropicamide and atropine treated eyes, the mean PD significantly increased from 15 min until 12 h after treatment with a maximum PD at 45 min (+2.7 mm and + 2.4 mm respectively). Following tropicamide and atropine instillation, IOP increased significantly in treated eyes at 45 min (+2.9 mmHg) and 15 min (+5.2 mmHg) respectively, compared to untreated eyes. No significant effects were found on TP, in both tropicamide and atropine treated eyes at any time. No effects were observed in the untreated eyes on any of the parameters evaluated for both drugs.ConclusionsTopical treatment with 0.5% tropicamide and 1% atropine induced mydriasis in healthy pet rabbits and could be considered as effective options when mydriatic/cycloplegic drugs are required.
Contrast computed tomography dacryocystorhinography identifies nasolacrimal duct obstruction secondary to chronic dental disease in two chinchilla langeria
Authors: Hisey Erin A. , Rodriguez Paula , Tarbert Danielle K. , Paul‐Murphy Joanne R. , Hendrickson Carli , Brust Kelsey , Maggs David J. , Leonard Brian C. 
Published: September 2024

AbstractObjectiveTo determine the impact of chronic dental disease on the nasolacrimal duct of chinchillas using contrast CT dacryocystorhinography.Animals StudiedTwo 12‐year‐old female chinchillas with uni‐ or bilateral ocular discharge and a history of chronic, moderate (Chinchilla 1, one‐year) or severe (Chinchilla 2, three‐years) dental disease.ProceduresContrast CT dacryocystorhinography was performed to identify abnormalities in the nasolacrimal duct and dentition, and to correlate those changes.ResultsChinchilla 1 had a focal soft tissue attenuating expansion of the maxillary bone rostral to the first left premolar interpreted as possible abscessation causing deviation of the nasolacrimal duct over its dorsomedial margin. The right nasolacrimal duct appeared normal. Chinchilla 2 had periapical abscessation of a retained subgingival left maxillary incisor fragment which extended into the nasal cavity causing focal narrowing and distal dilation of the left nasolacrimal duct. Complete contrast infusion of the right nasolacrimal duct could not be completed on Chinchilla 2. A focal area of superficial corneal fibrosis ipsilateral to the obstructed nasolacrimal duct was also identified in Chinchilla 2. Treatment consisted of occlusal adjustments to correct the coronal elongation, systemic antibiotics (metronidazole and either marbofloxacin or azithromycin), and topical tear replacement therapy and diclofenac as needed. Ocular discharge decreased in both chinchillas but did not resolve long‐term in either animal.ConclusionsChronic dental disease including periapical abscessation in chinchillas can obstruct the nasolacrimal duct, leading to impaired tear drainage. Management of dental disease is crucial to maintain patency of the nasolacrimal duct.
Characteristics and diagnostic performance of nonechoplanar diffusion‐weighted imaging in detecting canine tympanokeratoma (cholesteatoma)
Authors: Coeuriot Charlotte , Gaillot Hugues , Agoulon Albert , Madec Stephane , Michel Guillaume , Prelaud Pascal , Briand Amaury , Bensignor Emmanuel , Bruet Vincent , Abadie Jérôme , Ruel Yannick , Fusellier Marion 
Published: September 2024

AbstractTympanokeratomas (cholesteatomas) are destructive keratinic masses of the middle ear that are often treated surgically. In humans, nonechoplanar (non‐EP) diffusion‐weighted (DW) MRI is efficient in diagnosing tympanokeratomas and differentiating recurrent tympanokeratomas from granulation or fibrous tissue after surgery. The objectives of this study were to (1) determine the characteristics of non‐EP DWI of histologically or cytologically confirmed canine tympanokeratomas, (2) determine the performance of non‐EP DW images, apparent diffusion coefficient (ADC) map and ADC values in discriminating between tympanokeratomas and other causes of otitis media in dogs, and (3) find an optimal ADC cut‐off value. Medical records of dogs diagnosed on MRI with otitis media in two veterinary hospitals were retrospectively reviewed. Sixty‐two ears with a cytological or pathological diagnosis of either tympanokeratoma (36/62) or nontympanokeratoma otitis media (26/62) were selected. Diffusion‐weighted images had an accuracy of 77.4%, a sensitivity of 94.4%, and a specificity of 53.8% for the detection of tympanokeratoma. The ADC value of middle ear content ranged from 517 to 1355.10−6 mm2/s in tympanokeratoma and from 454 to 2447 × 10−6 mm2/s in nontympanokeratoma otitis media. An ADC value below 916 × 10−6 mm2/s interpreted as a tympanokeratoma yielded an accuracy of 78.7%, a sensitivity of 92.6%, and a specificity of 60%. In the study population, combined qualitative analysis of DW images and ADC maps was the most effective method for diagnosing tympanokeratomas with an accuracy of 80.9%, a sensitivity of 92.6%, and a specificity of 65%.