bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gonadal macrophage infiltration in congenital lipoid adrenal hyperplasia
Authors: Ishii Tomohiro , Fukuzawa Ryuji , Sato Takeshi , Muroya Koji , Adachi Masanori , Ihara Kenji , Igaki Junko , Hasegawa Yukihiro , Sato Seiji , Mitsui Toshikatsu , Hasegawa Tomonobu 
Published: May 2016

Objective
Congenital lipoid adrenal hyperplasia (lipoid CAH) results in impairment of adrenal and gonadal steroidogenesis caused by STAR mutations. Our previous study revealed upregulation of genes associated with inflammatory or immune response and macrophage infiltration in the adrenal cortex of Star-knockout mice. This study aimed at investigating macrophage infiltration in the gonads from human patients with lipoid CAH.

Design
This study includes seven patients with lipoid CAH who underwent gonadectomy: two XX women (age, 22 and 40 years) and five XY boys (1 year). Two women with ovarian cysts (32 and 40 years) and six boys with autopsy or tumor (1 year) were examined as controls. Immunohistochemical analysis of their gonads was performed to determine steroidogenic cells by NR5A1 or CYP17A1 and macrophages by IBA1 or CD68.

Results
An increased number of macrophages infiltrated into the ovaries of lipoid CAH and consisted of two subpopulations: one scattered within and around a layer of theca cells of maturing follicles and the other massively aggregated in the stroma. Abundant cytoplasmic lipid droplets were observed not only in the theca cells but also in the stromal macrophages. There was no significant difference in the number of macrophages in the testicular interstitium between lipoid CAH (95% confidence interval (95% CI: 19.3–47.7 per 0.2mm2) and controls (95% CI: 13.3–25.8 per 0.2mm2) (P=0.10).

Conclusions
These results demonstrate that macrophages infiltrate the ovaries of lipoid CAH, where the theca cells and the stromal macrophages have abundant cytoplasmic lipid droplets.
Higher diurnal salivary cortisol levels are related to smaller prefrontal cortex surface area in elderly men and women
Authors: Stomby Andreas , Boraxbekk Carl-Johan , Lundquist Anders , Nordin Annelie , Nilsson Lars-Göran , Adolfsson Rolf , Nyberg Lars , Olsson Tommy 
Published: May 2016

Objective
Elevated cortisol levels with aging have been associated with atrophy of the hippocampus and prefrontal cortex (PFC), as well as with impaired cognitive functions in men. However, coexisting diseases have confounded many studies examining these relationships. Studies in women are lacking. Our objective was to test whether salivary cortisol levels were related to morphology of the hippocampus and the PFC, and to cognitive performance.

Design
A cross-sectional study including 200 elderly (55–80 years old) men and women.

Method
We used magnetic resonance imaging, tests of episodic-, semantic-, and working memory, visuospatial ability, and cortisol levels in four saliva samples collected during 1 day.

Results
Area under the curve (AUC) for cortisol levels was negatively related to cortical surface area of the left anterior cingulate gyrus (caudal P<0.001; rostral P=0.006), right lateral orbitofrontal cortex (P=0.004), and right rostral middle frontal gyrus (P=0.003). In women, there was also a negative relationship with cortical surface area in the left rostral middle frontal gyrus (P=0.006). No relationship was found between cortisol levels and hippocampal volume.

Conclusion
This study suggests that the structure of the medial PFC is related to cortisol levels in both elderly women and men.
The Impact of ROA, BOPO, and FDR to Indonesian Islamic Bank's Mudharabah Deposit Profit Sharing
Authors: Harfiah Laila Mugi , Purwati Atiek Sri , Ulfah Permata 
Published: May 2016

This study aims to determine the effect of profitability ratio (ROA) the cost-revenue ratio (BOPO) and financing to deposit ratio (FDR) toward profit sharing of time deposit mudharaba in Islamic banking in Indonesia. This research is a quantitative study using heading the entire population of Islamic banks in Indonesia and the sample was selected using purposive sampling method. Samples were obtained at 7 Islamic banks and research data in the form of quarterly reports Islamic Banks 2011-2014 period. The analysis namely with the used is a multiple linear regression analysis. The results of the data analysis showed that ROA, BOPO and FDR significant positive effect on the level of profit sharing of time deposit mudharaba. Is divided in changes in the rise and fall rate for the time deposits mudharaba can be explained 47.9 percent by ROA, BOPO and FDR, while 52.1 percent can be explained by other variables not examinedDOI: 10.15408/etk.v15i1.3109
Building constructions and structures Part I. classification of buildings according to framework
Authors: Lámer G. 
Published: May 2016

The study involves structures applicable in building structures. Present part I includes structures applicable in building structures. Building structures for this are classified according to functions. Two main groups can be distinguished: frameworks and building structures ensuring serviceability. Further subgroups can be distinguished within both main groups.
Upon examining the structural frame it is clear that buildings can be well classified according to frameworks. The four-element-classification of vertical load-bearing structural elements, walls and pillars — wall frame, pillar frame, mixed frame and frames without walls and pillars — provide a rather simple classification. Considering the different construction technologies of walls and pillars, and frameworks differing from these provides a multi-element classification. Various subgroups can be distinguished based on the relationship between walls and pillars as well as ceilings within the individual groups.
Orientation dependence of swift heavy ion track formation in potassium titanyl phosphate
Authors: Ma Yu-Jie , Mota Santiago Pablo , Rodriguez Matias D. , Kremer Felipe , Schauries Daniel , Afra Boshra , Bierschenk Thomas , Llewellyn David J. , Lu Fei , Ridgway Mark C. , Kluth Patrick 
Published: May 2016

Abstract
Facile Synthesis of Semiconductor-Metal Hybrid Nanoparticles with an Anisotropic Structure
Authors: Ohnuma Akira , Iwasaki Kouta 
Published: May 2016

ABSTRACTHere we report a facile and versatile procedure for the preparation of semiconductor-metal hybrid nanoparticles with an anisotropic structure consisting of bismuth telluride (Bi2Te3) and gold (Au) (or silver (Ag)) nanoparticles. We simply added flake-shaped Bi2Te3 nanoparticles (Bi2Te3 nanoflakes) and trisodium citrate to an aqueous Au or Ag precursor solution heated to boiling. The edge part of the Bi2Te3 nanoflake was preferentially modified with Au or Ag nanoparticles, and the Bi2Te3-Au hybrid nanoparticles had a broad peak of light absorption around the visible region and a higher thermoelectric power factor than ordinary Bi2Te3 nanoflakes. Because of the simplicity of the procedure, the hybrid nanoparticles are expected to be used as a new class of functional materials in the large scale production.
VIOLÊNCIA OBSTÉTRICA: VIVÊNCIAS DE SOFRIMENTO ENTRE GESTANTES DO BRASIL
Authors: Barboza Luciana Pereira , Mota Alessivânia 
Published: May 2016

Esse texto teve como objetivo realizar uma revisão de literatura sobre as práticas de violência obstétrica que ocorrem nas maternidades no momento do parto, suas implicações no bem-estar subjetivo das mulheres e as relações sociais que estruturam estas práticas. Realizou-se uma busca dos artigos relacionados ao tema nas bases de dados eletrônico Lilacs e Scielo, que foram agrupados em três grandes temas centrais. Na primeira parte do texto analisou-se a base histórica e social relacionada ao desenvolvimento desta violência, destacando as relações de poder e dominação da medicina e do machismo na estruturação dessas práticas assistenciais. A medicina, através da patologização do parto e sua consequente medicalização, assume o controle deste processo e objetifica a mulher, que perde a autonomia sobre teu corpo e sofre agressões físicas, psicológicas e sexuais nas maternidades, e ao invés de cuidado é desenvolvido relações de opressão nestas instituições. Na segunda parte identificou-se e foi descrito como as várias formas de violência são reproduzidas nas rotinas dos serviços de saúde e naturalizadas nos fluxos assistenciais, abordando as falas de mulheres que vivenciaram essas agressões e o sofrimento desencadeado por estas práticas. Na terceira parte abordou-se a política de humanização do parto que está sendo estimuladas pelo Ministério da Saúde desde 2000 com a Política Nacional de Humanização do Parto, e foram analisados os avanços da proposta enquanto possibilidade de modificação das relações de opressão que ocorrem no momento do parto e fortalecimento do protagonismo das mulheres.
REFLEXÕES ACERCA DE UM PROCESSO CRÍTICO DE ENSINO E FORMAÇÃO EM PSICOLOGIA
Authors: De Oliveira Santiago Maria das Graças , Solaterrar da Silva Carneiro Ueslei 
Published: May 2016

Quem tem sede, necessita de água limpa; quem tem fome, precisa de comida substanciosa para alimentar o corpo. Mas são tantas as nossas sedes e ambiciosas as nossas necessidades alimentares que é preciso entrar no campo dos desejos e esperanças, das ansiedades e realizações, dos prazeres e desprazeres desta vida, tão severina para uns e tão estrelada para outros. É preciso pensarmos então em como ir além do que está posto; como poderemos seguir viagem rumo a uma Psicologia e Educação contra a barbárie. Nesse sentido, a questão central que se coloca é: de quais instrumentos potentes dispõe o nosso rico saber psicológico para contribuir com o rompimento do instituído e com todas as formas de humilhação social existentes?
Comprehensive Care of Patients with Spastic Paresis – A Long-Term Commitment
Authors: Ward Anthony , Jost Wolfgang , Jech Robert , Gracies Jean-Michel ,   North Staffordshire Rehabilitation Centre, Haywood Hospital, Stoke-on-Trent, UK,   Parkinson’s Disease Clinic Wolfach, University of Freiburg, Germany,   Department of Neurology, Charles University, Prague, Czech Republic,   Henri Mondor University Hospital, Créteil, France
Published: May 2016

Spastic paresis is a frequent complication of lesions to central motor pathways. Patients who develop spasticity require specialised rehabilitation programmes to alleviate their symptoms, help them to relearn motor skills and regain some independence. Long-term management of patients with spastic paresis requires a comprehensive approach that addresses the patient’s physical needs and mental wellbeing, and continues throughout all stages of the rehabilitation process.There are three pillars of success for long-term rehabilitation programmes in spastic paresis. Since most human behaviour is goal-directed, the first is to employ patient-centred goal setting to engage and motivate patients to play an active part in their own rehabilitation. Goals should be meaningful for and achievable by the patient, and revised as necessary. The second foundation of success is to ensure detailed clinical assessment, using appropriate spasticity assessment scales to inform Botulinum toxin treatment plans -doses and muscles to be injected. Lastly, the use of guided self-rehabilitation programmes encourages an active role for patients in their treatment and maximises outcomes.This paper summarises proceedings from theComprehensive Care of Patients with Spastic Paresis: A Long-Term Commitmentsymposium, at the International Society of Physical and Rehabilitation Medicine World Congress, 2015.
Contaminación del suelo en la zona minera de Rasgatá Bajo (Tausa). Modelo conceptual
Authors: Guerrero Useda María Eugenia , Pineda Acevedo Vanessa 
Published: May 2016

<p>Se desarrolló un modelo conceptual del riesgo de contaminación físico química del suelo en la vereda Rasgatá Bajo. Esta vereda del municipio de Tausa, en Cundinamarca, está en la zona limítrofe del declarado por la Corporación Autónoma Regional de Cundinamarca en 2009, Distrito Regional de Manejo Integrado de los Recursos Naturales Renovables Páramo Guargua y Laguna Verde. La vocación productiva local por tradición ha sido el cultivo de papa (<em>Solanum tuberosum L</em>) y la extracción y transformación de arcilla y carbón, actividades con graves impactos sobre el suelo, por lo que el objetivo del proyecto fue identificar y evaluar la condición de este recurso en territorios donde confluyen actividades de extracción y transformación de arcilla y carbón. Se siguió un enfoque metodológico mixto que combinó investigación documental, observaciones <em>in situ </em>y medición de características físico químicas para determinar las fuentes y tipos de contaminantes con riesgo de afectar el suelo aledaño a las faenas mineras y con impactos toxicológicos para las personas, la fauna y la flora. Los datos obtenidos aportarán al rediseño y evaluación de los planes de manejo ambiental local.</p>
Outcomes for Hip Arthroscopy According to Sex and Age
Authors: Frank Rachel M. , Lee Simon , Bush-Joseph Charles A. , Salata Michael J. , Mather Richard C. , Nho Shane J. 
Published: May 2016

Background:Factors such as age and sex are postulated to play a role in outcomes following arthroscopy for femoroacetabular impingement; however, to our knowledge, no data currently delineate outcomes on the basis of these factors. The purpose of this study was to compare clinical outcomes of patients undergoing hip arthroscopy for femoroacetabular impingement according to sex and age.Methods:One hundred and fifty patients undergoing hip arthroscopy for femoroacetabular impingement by a single fellowship-trained surgeon were prospectively analyzed, with 25 patients in each of the following groups: female patients younger than 30 years of age, female patients 30 to 45 years of age, female patients older than 45 years of age, male patients younger than 30 years of age, male patients 30 to 45 years of age, and male patients older than 45 years of age. The primary outcomes included the Hip Outcome Score Activities of Daily Living Subscale (HOS-ADL), Hip Outcome Score Sport-Specific Subscale (HOS-Sport), the modified Harris hip score (mHHS), and clinical improvement at the time of follow-up.Results:At a minimum 2-year follow-up, all groups demonstrated significant improvements in the HOS-ADL, the HOS-Sport, and the mHHS (p < 0.0001). Female patients older than 45 years of age scored significantly worse on the HOS-ADL, HOS-Sport, and mHHS compared with female patients younger than 30 years of age (p < 0.0001 for all) and female patients 30 to 45 years of age (p < 0.017 for all). Male patients older than 45 years of age scored significantly worse on all outcomes compared with male patients younger than 30 years of age (p ≤ 0.011 for all) and male patients 30 to 45 years of age (p ≤ 0.021 for all). Incorporating both sexes, patients older than 45 years of age scored significantly worse on all outcomes compared with patients younger than 30 years of age (p < 0.0001 for all) and patients 30 to 45 years of age (p ≤ 0.001 for all). Female patients older than 45 years of age had significantly reduced radiographic preoperative joint space width compared with the two other female groups and the male groups who were 45 years of age or younger (p < 0.05 for all).Conclusions:Although all patients had significant improvements in all outcomes following hip arthroscopy, patients older than 45 years of age performed worse than younger patients, with female patients older than 45 years of age demonstrating the lowest outcome scores. In the age group of 45 years or younger, female patients performed as well as male patients in terms of hip clinical outcome scores. Overall, care must be individualized to optimize outcomes following hip arthroscopy for femoroacetabular impingement.Level of Evidence:PrognosticLevel II. See Instructions for Authors for a complete description of levels of evidence.
Capital Femoral Growth Plate Extension Predicts Cam Morphology in a Longitudinal Radiographic Study
Authors: Morris William Z. , Weinberg Douglas S. , Gebhart Jeremy J. , Cooperman Daniel R. , Liu Raymond W. 
Published: May 2016

Background:
Recent evidence has suggested that cam morphology may be related to alterations in the capital femoral growth plate during adolescence. The purpose of this study was to evaluate the relationship between capital femoral growth plate extension and cam morphology in a longitudinal radiographic study.

Methods:
We used a historical, longitudinal radiographic collection to identify 96 healthy adolescents (54 boys and 42 girls) with at least 5 consecutive annual radiographs of the left hip including closure of the capital femoral physis. We reviewed 554 anteroposterior radiographs of the left hip to measure the anteroposterior modification of the alpha angle of Nötzli and of the superior epiphyseal extension ratio (EER), measured as the ratio of extension of the capital femoral epiphysis down the femoral neck relative to the diameter of the femoral head. Measurements were made at 3 points in femoral head maturation corresponding to the Oxford bone age (OBA) femoral head stages 5, 6, and 7/8.

Results:
There was a mean increase in the anteroposterior alpha angle (10.7° ± 14.0°) and EER (0.12 ± 0.08) between OBA stages 5 and 7/8, corresponding to maturation and closure of the capital femoral physis. There was a positive correlation between the final anteroposterior alpha angle and both the final EER (r = 0.60) and the change in the EER (r = 0.58). A receiver operating characteristic curve generated to predict an anteroposterior alpha angle of ≥78° through the EER demonstrated an area under the curve of 0.93, indicating that an increasing EER had excellent diagnostic accuracy for predicting concurrent cam morphology.

Conclusions and Clinical Relevance:
Superior epiphyseal extension was directly and temporally associated with an increase in anteroposterior alpha angle and more cam-like morphology. This alteration in the capital femoral epiphysis occurred immediately before physeal closure (OBA stage 7/8). Given the association of epiphyseal extension with activities that increase shear forces across the physis, we proposed that epiphyseal extension may be an adaptive mechanism to stabilize the physis and prevent slipped capital femoral epiphysis.
Synthesis, Characterization and Antimicrobial Evaluation of Novel Mannich Bases Containing Pyrazole-5-One Phosphonates
Authors: Rani V. E. , Ravindranath L. K. 
Published: May 2016

Background:
Newly synthesised compounds of phosphonates were prepared by condensation of diethylphosphate with imine which undergoes a reaction of mannich bases with pyrazole containing schiffs base. The base was prepared by condensation of aldehyde with primary amine. These newly synthesised derivatives were characterised by spectral analysis.

Objective:
Mannich bases are very important to synthesize wide variety of natural products and pharmaceuticals.

Method:
Thin Layer Chromatography was performed on aluminum sheet of silica gel 60F254, E-Merk, Germany using iodine as visualizing agent. IR Spectra were recorded as KBr pellets on Perkin-Elmer 1000 units, instruments. All 1H and 13C-NMR spectra were recorded on a Varian XL-300 spectrometer operating at 400MHz and 75 MHz. 31P-NMR spectra were recorded on a Varian XL-spectrometer operating at 161.89MHz. The compounds were dissolved in dimethylsulfoxide and Chemical shifts were referenced to Trimethylsilane (1H and 13C-NMR) and 85% phosphoric acid (31P-NMR).

Results:
Some of the novel synthetic compounds of Pyrazole Mannich base-Phosphonates showed great potential in field of medicinal chemistry and good biological activity.

Conclusion:
It can be concluded that this class of compounds certainly holds great potential for the discovery of novel classes of antimicrobial agents.
Association of Urinary Biomarkers of Inflammation, Injury, and Fibrosis with Renal Function Decline: The ACCORD Trial
Authors: Nadkarni Girish N. , Rao Veena , Ismail-Beigi Faramarz , Fonseca Vivian A. , Shah Sudhir V. , Simonson Michael S. , Cantley Lloyd , Devarajan Prasad , Parikh Chirag R. , Coca Steven G. 
Published: May 2016

Background and objectives
Current measures for predicting renal functional decline in patients with type 2 diabetes with preserved renal function are unsatisfactory, and multiple markers assessing various biologic axes may improve prediction. We examined the association of four biomarker-to-creatinine ratio levels (monocyte chemotactic protein-1, IL-18, kidney injury molecule-1, and YKL-40) with renal outcome.

Design, setting, participants, & measurements
We used a nested case-control design in the Action to Control Cardiovascular Disease Trial by matching 190 participants with ≥40% sustained eGFR decline over the 5-year follow-up period to 190 participants with ≤10% eGFR decline in a 1:1 fashion on key characteristics (age within 5 years, sex, race, baseline albumin-to-creatinine ratio within 20 μg/mg, and baseline eGFR within 10 ml/min per 1.73 m2), with ≤10% decline. We used a Mesoscale Multiplex Platform and measured biomarkers in baseline and 24-month specimens, and we examined biomarker associations with outcome using conditional logistic regression.

Results
Baseline and 24-month levels of monocyte chemotactic protein-1-to-creatinine ratio levels were higher for cases versus controls. The highest quartile of baseline monocyte chemotactic protein-1-to-creatinine ratio had fivefold greater odds, and each log increment had 2.27-fold higher odds for outcome (odds ratio, 5.27; 95% confidence interval, 2.19 to 12.71 and odds ratio, 2.27; 95% confidence interval, 1.44 to 3.58, respectively). IL-18-to-creatinine ratio, kidney injury molecule-1-to-creatinine ratio, and YKL-40-to-creatinine ratio were not consistently associated with outcome. C statistic for traditional predictors of eGFR decline was 0.70, which improved significantly to 0.74 with monocyte chemotactic protein-1-to-creatinine ratio.

Conclusions
Urinary monocyte chemotactic protein-1-to-creatinine ratio concentrations were strongly associated with sustained renal decline in patients with type 2 diabetes with preserved renal function.