bluuebunny/crossref_metadata_2025_split huggingface dataset:
Difficult-to-treat psoriatic arthritis. Data from the All-Russian registry of patients with psoriatic arthritis
Authors: Loginova E. Yu. , Korotaeva T. V. , Gubar E. E. , Korsakova Yu. L. , Nasonov E. L. 
Published: October 2024

Objective: to characterize patients with difficult-to-treat (D2T) psoriatic arthritis (PsA) and to assess risk factors for its development.Material and methods. The study included 263 PsA patients treated with biologic disease- modifying antirheumatic drugs (bDMARDs) or targeted synthetic DMARDs (tsDMARDs) and followed up for ≥2 years in the All-Russian Registry of PsA Patients. All patients underwent a standard clinical and laboratory examination, and concomitant diseases were recorded. PsA activity was assessed using DAPSA index and minimal disease activity criteria.Results and discussion. 152 (57.8%) patients who received 1 bDMARD/tsDMARD for 2 years achieved remission/low disease activity (LDA) according to DAPSA and were categorized as having non-D2T PsA. Other 111 (42.2%) patients switched ≥2 bDMARDs/tsDMARDs within 2 years, 71 (27%) of them achieved remission/LDS, and 40 (15.2%) patients who continued to have high or moderate PsA activity met the D2T criteria. A comparative analysis of 40 patients (20 men and 20 women) with D2T PsA and 152 patients (78 men and 74 women) with PsA who did not fulfil the D2T criteria was performed. It was found that patients with D2T PsA had a significantly longer duration of PsA (p=0.017), more frequent polyarthritis (p=0.014), dactylitis (p=0.004), enthesitis (p=0.001), BSA >10% (p=0.008), onycholysis (p=0.001), HAQ >0.5 (p=0.039), depression (p=0.007) and elevated blood uric acid levels (p=0.023).Conclusion. In real-life clinical practice, the D2T variant of PsA is reported in 15% of cases. Treatment-resistant PsA patients are characterized by a longer duration of PsA, more widespread severe psoriasis with onycholysis and are more likely to have polyarthritis, dactylitis, enthesitis and functional disorders at the time of bDMARD prescription, as well as concomitant diseases, especially depression and hyperuricaemia.
Brain-computer interfaces based on near-infrared spectroscopy and electroencephalography registration in post-stroke rehabilitation: a comparative study
Authors: Mokienko O. A. , Lyukmanov R. Kh. , Bobrov P. D. , Isaev M. R. , Ikonnikova E. S. , Cherkasova А. N. , Suponeva N. A. , Piradov M. A. 
Published: October 2024

Motor imagery training under the control of a brain-computer interface (BCI) facilitates motor recovery after stroke. The efficacy of BCI based on electroencephalography (EEG-BCI) has been confirmed by several meta-analyses, but a more convenient and noise-resistant method of near-infrared spectroscopy in the BCI circuit (NIRS-BCI) has been practically unexamined; comparisons of the two types of BCI have not been performed.Objective: to compare the control accuracy and clinical efficacy of NIRS-BCI and EEG-IMC in post-stroke rehabilitation.Material and methods. The NIRS-BCI group consisted of patients from an uncontrolled study (n=15; 9 men and 6 women; age – 59.0 [49.0; 70.0] years; stroke duration – 7.0 [2.0; 10.0] months; upper limb paresis – 47.0 [35.0; 54.0] points on the Fugl-Meyer Assessment for motor function evaluation of the upper limb – FM-UL). The EEG-IMC group was formed from the main group of the randomized controlled trial “iMove” (n=17; 13 men and 4 women; age – 53.0 [49.0; 70.0] years; stroke duration – 10.0 [6.0; 13.0] months; upper limb paresis – 33.0 [12.0; 53.0] points on the FM-UL). Patients participated in a comprehensive rehabilitation program supplemented by BCI-guided movement imagery training (average of 9 training sessions).Results. Median of average BCI control rates achieved by the patients was 46.4 [44.2; 60.4]% in the NIRS group and 40.0 [35.7; 45.1]% in the EEG group (p=0.004). For the NIRS-BCI group, the median of the maximum BCI control accuracy achieved was 66.2 [56.4; 73.7]%, for EEGBCI – 50.6 [43.0; 62.3]% (p=0.006). The proportion of patients who achieved a clinically significant improvement according ARAT and the proportion of patients who achieved a clinically significant improvement according FM-UL were comparable in both groups. The NIRS-BCI group showed greater improvement in motor function compared to the EEG-BCI group according to Action Research Arm Test (ARAT; an increase of 5.0 [4.0; 8.0] points compared to an increase of 1.0 [0.0; 3.0] points; p=0.008), but not according to FM-UL scale (an increase of 5.0 [1.0; 10.0] and 4.0 [2.0; 5.0] points, respectively; p=0.455).Conclusion. NIRS-BCI has an advantage in control accuracy and ease of use in clinical practice. Achieving higher control accuracy of BCI provides additional opportunities for the use of game feedback scenarios to increase patient motivation.
Humoral serotonin and neuropsychological status of patients with dizziness
Authors: Borodulina I. I. , Karakulova Yu. V. 
Published: October 2024

Dizziness is often accompanied by affective disorders such as anxiety and depression, in the occurrence of which the role of the serotonergic system is discussed.Objective: to investigate the serotonin content in blood serum and neuropsychological status in patients with vestibular and non-vestibular dizziness.Material and methods. The study included 97 patients. Two observation groups were formed according to the type of dizziness complaints. The first group (n=47) comprised patients with vestibular (systemic) dizziness against a background of peripheral vestibulopathy, the second group (n=35) comprised patients with non-vestibular (non-systemic) dizziness with a diagnosis of probable persistent postural-perceptual dizziness (PPPD). The control group (n=15) consisted of patients without complaints of dizziness. Neurological and otoneurological status, psychoemotional parameters (level of anxiety and depression) and cognitive functions were analyzed, and the quantitative level of serotonin in blood serum was determined by enzyme immunoassay.Results. The study revealed a significant decrease in the serum serotonin levels in vestibular and non-vestibular dizziness; a lower serotonin level was found in non-vestibular dizziness (p<0.05). The presence of affective disorders did not correlate with a decrease in serotonin levels in vestibular dizziness against a background of peripheral vestibulopathy. It is assumed that a decrease in serotonin content plays a role in pathogenesis of vestibular dizziness on the background of peripheral part of vestibular system involvement.Conclusion. We demonstrated possibility of using the level of serotonin in peripheral blood as an objective laboratory marker of vestibular and non-vestibular dizziness in general clinical medical practice.
Efficacy and safety of cladribine tablets in multiple sclerosis in real-world clinical practice
Authors: Peshkin A. N. , Kotov S. V. , Toniya G. T. , Sutormin M. V. , Eltayoury A. F. 
Published: October 2024

Cladribine has a well-defined activity against lymphocytes, leading to their selective depletion.Objective: to determine the efficacy and safety of cladribine in the treatment of multiple sclerosis (MS) in real-world clinical practice.Material and methods. The study involved 82 patients (57 women and 25 men, mean age 36.4±9.3 years) with a disease duration of 2.2±1.5 years. Seven (9%) patients had secondary progressive MS (SPMS), 6 (7%) had rapidly progressive MS (RPMS) and 69 (84%) had highly active MS (HAMS). According to the instructions for use, oral therapy with cladribine was administered in two short courses (up to 10 days per year) to achieve a long-term effect on the immune system. The dose of cladribine was calculated based on the body weight.Results. The average frequency of exacerbations per year before starting therapy was 1.6, while it decreased to 0.2 during cladribine therapy. An exacerbation was observed in 18 patients (22%) at the end of the first course of cladribine treatment and in one patient (2.6%) after the second treatment course. Thus, the number of exacerbations decreased by 78% after the first year of treatment and by 97.4% after the second year of treatment. The mean EDSS score was 3.2±2.5 points before the start of treatment, 3.6±2.5 points after the first course of treatment and 3.4±2.5 points after the second course (p>0.05). MRI results showed a decrease in disease activity by 83% after the first course of cladribine therapy and by 97.4% after the second course. No serious adverse events occurred in any of the patients.Conclusion. We demonstrated efficacy and safety of cladribine in real-life clinical practice in MS patients with frequent exacerbations and rapid disability progression (SPMS, RPMS, HAMS).
Surveying the Types of Tables in Ancient Greek Texts
Authors: Tolsa Cristian 
Published: October 2024

Abstract
We may take tables for granted. However, due to a variety of factors, tables were a rarity in the history of ancient Greek culture, used only limitedly in very special contexts and generally in a non-systematic way, except in astronomy. In this paper I present the main types of tables that can be found in ancient Greek texts: non-ruled columnar lists (accounts and other types of informal tables), ruled columnar lists (mostly astronomical tables), and symmetric tables (mainly Pythagorean displays of numbers).
The application of social network analysis in applied linguistics research: a systematic review
Authors: Li Citing , Li Zibei , Gao Xuesong (Andy) 
Published: October 2024

Abstract
Social network analysis (SNA) has recently drawn increasing scholarly attention in applied linguistics research in response to the social turn in the field. In this review, we analyze and identify the methodological characteristics and topical concerns of articles addressing SNA in Social Science Citation Index (SSCI) journals. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we identify a total of 60 articles published between 1980 and 2023. Our analysis reveals that a growing body of research is adopting qualitative and mixed methods to examine the relationships between social networks and language learning, teaching and use. These findings confirm that social context constitutes an essential part of the ecosystem intertwined with various cognitive, social, and psychological factors, which have a synergistic impact on language learning and teaching. While these studies show that social networks afford learners with valuable linguistic, emotional, and social resources, they reveal that networks may also exert negative influences in their learning behaviors in some contexts. We conclude the review with recommendations for future research to broaden the scope of investigations and consider exploring how different types of social networks at meso- and macro-levels may influence the learning and teaching of language.
Research on the influence of cemented carbide micro-textured structure on tribological properties
Authors: Tang Zhixiong , Ge Zhenghao , Li Jie 
Published: October 2024

Abstract
To examine how micro-textures with distinct structures affect the tribological properties of cemented carbide tool-cutting processes, various micro-textures were meticulously fabricated on YG8 cemented carbide blocks. Subsequently, friction and wear experiments were systematically conducted to examine the microstructure nuances resulting from the diverse structures. The influence of these micro-textures on the friction coefficient of cemented carbide and its underlying factors was comprehensively analyzed. To further investigate the impact of these micro-textures on the cutting force in cemented carbide tools, finite element analysis was conducted. Identical micro-textures used in the tribological experiment were applied to the tool, followed by milling simulations aimed at elucidating the impact of these varied micro-textures on the three-dimensional cutting force exerted by the tool. Empirical investigations and finite element analyses revealed that micro-textures characterized as parallel (parallel to the main cutting edge), perpendicular (perpendicular to the main cutting edge), and a combination of “parallel + perpendicular” significantly enhance the tribological properties of cemented carbide tools. This enhancement is evident in the reduction of both the friction coefficient and cutting force of the tool. Particularly noteworthy is the substantial efficacy of vertical micro-textures in minimizing both the frictional force and cutting force, resulting in a noteworthy reduction of the primary cutting force by more than 60% and a concomitant alleviation of tool feeding force by approximately 25%.
Thermal-hydraulic simulation of loss of flow accident for WWR-S research reactor
Authors: El-Morshedy Salah El-Din , Moawed Mohamed , Abdelrahman Mohamed A. , Abu Elnour Asmaa G. , Taha Mohammed 
Published: October 2024

Abstract
A thermal-hydraulic model has been developed by RELAP5 code to simulate the thermal-hydraulic behavior of a WWR-S research reactor under loss of flow accident (LOFA). The reactor power is 2 MW with downward flow direction and different types of fuel bundles of different power densities and different coolant flow-rates. The simulation is performed for two scenarios; protected and unprotected LOFA. In the protected LOFA scenario; Scram is triggered as soon as the coolant flow rate reaches 85 % of its nominal value while in the unprotected LOFA scenario; the reactor continues operation during pump cost-down and natural circulation flow. Once the flow is low enough, the buoyancy force increases in the core leading to flow inversion phenomenon and establishment of a natural circulation mechanism within the core coolant channels in both scenarios. In the protected LOFA scenario, the coolant remains subcooled by a vast margin during transient while bulk boiling is predicted at the upper part of the core for the unprotected LOFA scenario. The heat fluxes leading to the onset of nucleate boiling and the critical heat flux are predicted and the safety margins are determined. The results for both scenarios are analyzed and discussed.
Das Glück der schönen Mädchen? Überlegungen zu einem spätantiken Kerkergraffito aus Korinth (IG IV2 3, 1274)
Authors: Wojciech Katharina 
Published: October 2024

Abstract
The article focuses on a graffito from Corinth, which was discovered in an ancient prison and very probably written by a prostitute: “νικᾷ ἡ τύχη το͂ν καλο͂ν κορασίον το͂ν φιλόντον τοὺς ἀγάμους”. On the one hand, the possible circumstances of the woman’s imprisonment are discussed in light of late antique prostitution laws. On the other hand, the Christian view of prostitution at the time is examined. Instead of assuming – as has been done so far – that the imprisoned prostitute shows remorse, the article looks for alternative interpretations and considers whether the lines could rather refer to the lack of alternatives to prostitution, suggesting a translation such as: “The happiness of the beautiful girls will prevail because they welcome the unmarried men!”
The role of presence of wormlike micelles of ionic surfactants on the sterilization efficiency of sodium hypochlorite
Authors: Khalil Rabah Ali , Hammad Fahad Jumaah 
Published: October 2024

Abstract
This paper describes an attempt to increase the sterilising efficacy of sodium hypochlorite (SH) by prolonging its shelf life in gel mode through the presence of wormlike micelles. No effect was observed on the presence of SH on the ratio of highest viscosity peak of 20:80 of 3 % (w/w) sodium dodecylsulfate (SDS) and cetyltrimethylammonium bromide (CTAB). On the other side, the presence of SH has a relatively negative effect on transformation process from spherical (three-dimensional, 3D) micelles to wormlike (one-dimensional, 1D) micelles. The gel state of the aqueous SH solution is maintained even at a ratio of 20:80 SDS:CTAB 3 % (w/w). Measurements of the biological activity of the gel using Staphylococcus aureus bacteria show that the sterilizing efficiency of SH is enhanced by the presence of 1D micelles. In contrast, the stability of SH using the kinetic method shows a sudden decrease in its stability due to the presence of 1D micelles, and the same is the case when both SDS and CTAB micelles are present. It was concluded that the increase in the biological activity of SH due to presence of micelles in gel or liquid mode resulted from their chemical interference, which acts as an antibacterial formulation.
Optimizing equine sperm quality: an alternative to single layer centrifugation for sperm isolation
Authors: Medica Ashlee Jade , Gibb Zamira , Aitken Robert John 
Published: October 2024

Graphical abstract

Abstract
In vitro semen purification techniques have been developed that seek to mimic the in vivo selection process in order to generate the highest possible chance of oocyte fertilization following artificial insemination. Numerous methods have been developed to isolate functional spermatozoa for artificial insemination, yet only one method, single-layer centrifugation using commercial preparations like EquiPure, has been widely employed. In this study, we have introduced a novel approach for isolating spermatozoa and compared their quality to those isolated using EquiPure. The AI port system (Memphasys, Ltd. in Sydney, Australia) features a disposable cartridge with an inoculation chamber for depositing extended semen and a harvest chamber for extracting isolated spermatozoa. These chambers are separated by a 5 µm polyethylene terephthalate (PETE) membrane, allowing highly motile spermatozoa to migrate from the inoculation chamber to the harvest chamber over a 20-minute period. This migration effectively leaves behind seminal plasma and other cell types, such as leukocytes. Comparative analyses between spermatozoa isolated with the AI port and EquiPure demonstrated that, across all measured sperm parameters, including yield, vitality, motility, morphology, DNA fragmentation, and mitochondrial superoxide generation, the AI port-isolated cells exhibited comparable or superior performance, particularly in terms of DNA fragmentation. In summary, the AI port system demonstrates the potential to efficiently isolate high-quality spermatozoa, possibly offering a cost-effective and user-friendly alternative that may enhance the success rates of artificial insemination in breeding programs.

Lay summary
This study aimed to create a new method for refining stallion semen to increase the likelihood of a successful pregnancy through artificial insemination. While there are existing techniques for isolating high-quality sperm, the most common involves a complicated process using a centrifuge, which spins the semen to separate it. This research introduces a new approach called the AI port system that uses a disposable cartridge with two separate chambers for putting in semen and getting out isolated sperm. A membrane between the chambers acts like a filter, letting highly motile sperm swim across, leaving behind unwanted substances like bacteria and blood cells. Compared to the centrifugation method, the AI port system effectively produces sperm with comparable or better quality in various aspects, including vitality, movement, shape, DNA integrity, and energy production. In summary, the AI port system is an easy-to-use alternative with the potential to improve the success of artificial insemination in horse breeding programs.
An unusual presentation of Wegener’s granulomatosis during pregnancy
Authors: Haridas Vikram Muralidhar , S Chandrashekara  , Dharmanand Balebail Gopalakrishna 
Published: October 2024

The occurrence of Wegener’s granulomatosis (WG), a multisystem autoimmune disease of unknown etiology, during pregnancy and postpartum is rare. We present here a rare case of a pregnant woman with corneal ulcer that occurred secondary to WG during the postpartum period.
Personality Traits and Common Ingroup Identity: Support for Refugee Policies Among Host Members
Authors: Çoksan Sami , Kekeli Burak , Turgut Buse , Sağdış Elif 
Published: October 2024

Türkiye, which has hosted the largest number of refugees in recent years, requires remedial intervention programs to facilitate adaptation and coexistence. The irony of harmony studies that guide these interventions seem incomplete due to limited sample characteristics and a lack of attention to personality traits. Hence, we aimed to explore relationships between personality traits, identification with common ingroup identity, and support for social policies toward refugees by sampling the advantaged majority and the disadvantaged largest minority in Türkiye across two correlational studies (Ntotal = 772). In Study 1, agreeableness, extraversion, openness, narcissism, and psychopathy were associated with support for positive social policies. On the other hand, neuroticism was linked with support for negative social policies. However, when identification with common ingroup identity was included in the model, the significance of personality traits in almost all models disappeared, indicating that only the prediction of identification with common ingroup identity remained. The findings of Study 2 replicated and extended the previous result by sampling disadvantaged group members. We suggest that it may be more effective to focus on intergroup variables rather than personality traits to strengthen support for refugee policies, as the overall findings pointed out.
Results of surgical treatment for drug-resistant temporal epilepsy and related predictors of negative post-surgery outcome
Authors: Al-Sahli O.A.M. , Tibekina L. M. , Ivanova A. E. 
Published: October 2024

Objective: to evaluate the results of surgical treatment and identify related predictors of unfavorable outcome in patients with temporal drug-resistant epilepsy (DRE) in long-term postoperative period.Material and methods. Fifty-one patients with temporal lobe DRE were examined using clinical, neuroimaging, electro- physiological, and laboratory research methods from June 2020 to June 2023. Anteromedial temporal lobectomy (AMLE) and selective amygdalohippocampectomy (SAHE) were performed in 38 (74.5%) and 13 (25.5%) cases, respectively. Postsurgery outcomes were evaluated in 51 patients 6 months later, continued in 43 and 20 patients 1 year and 2 years, respectively, afterwards.Results. The percentage of patients with significant improvement (Engel I/II) 6 months, 1 year and 2 years post-surgery was 82.4%, 72.1%, and 55.0%, respectively. After AMLE vs. SAHE, patients had a more favorable outcome while assessing seizure control. The predictors of unfavorable post-surgery outcome included a prolonged epilepsy course before surgery, the presence of electroencephalography-verified epileptiform activity in postoperative period, and repeated surgical intervention. Patient age, the presence of focal seizures evolving into bilateral tonic-clonic seizures as well as more frequent seizures before surgery were considered as potential predictors.Conclusion. The study results show that quite high effectiveness of seizure control in postoperative period in temporal DRE is quite high that may be accounted for by probability of removing epileptogenic foci and suppression of the mechanisms ensuring emergence and irritation of epileptic discharges. Nevertheless, effectiveness of surgical treatment fades off with time, which requires to further investigate the negative factors countering long-term post-surgery effect. In connection with this, a special attention should be paid to factors such as the presence of electroencephalography-verified epileptiform activity in postoperative period, repeated surgical intervention as well as prolonged epilepsy before surgery.