bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tragedy and ēthos in Andocides’ On His Return and at his later trial
Authors: Hill Theodore 
Published: October 2024

AbstractThis article argues that Andocides’ speech On His Return (Andocides 2) makes use of themes drawn from tragedy, including a near-quotation from Sophocles, in order to present the orator as deserving of pity and forgiveness. This neglected speech is therefore an ingenious work of rhetoric in its creation of ēthos and evocation of pathos. Moreover, it is a key document for the development of religious argumentation in the Athenian courts, and for the early reception of Sophocles. This also affects our interpretation of the two extant speeches from Andocides’ later trial in ca. 400, Against Andocides ([Lysias] 6) and On the Mysteries (Andocides 1), which both develop similar tragic themes in new directions.
The Value of the Creative Faculty in Man
Authors: Gill Eric 
Published: October 2024

What is the nature of Man—“Quid est homo? … Constituisti eum super omnia opera manuum tuarum.” In what is this superiority? “I have said you are gods.” In what way are men as gods? What do we know of God? Credo in Deum … creatorem coeli et terrae. Creatorem—what does create mean? The Shorter Oxford Dictionary says: to bring into being; to cause to exist; to form out of nothing; to originate.Now the existence of anything is dependent upon four causes. Take for example this table, (I) There is something that makes tables tables and not candlesticks; this kind of thing, not another kind. But, further, as an individual thing: this particular table and not that; a table like this one and not like that one—what makes tables tables, and this particular table this particular shape is the formal cause and without that cause this table would not exist.
Racial and ethnic disparities in social isolation and 11-year dementia risk among older adults in the United States
Authors: Grullon J. , Soong D. , Wong R. 
Published: October 2024

Abstract

Aims
Social isolation has been implicated in the development of cognitive impairment, but research on this association remains limited among racial-ethnic minoritized populations. Our study examined the interplay between social isolation, race–ethnicity and dementia.

Methods
We analyzed 11 years (2011–2021) of National Health and Aging Trends Study (NHATS) data, a prospective nationally representative cohort of U.S. Medicare beneficiaries aged 65 years and older. Dementia status was determined using a validated NHATS algorithm. We constructed a longitudinal score using a validated social isolation variable for our sample of 6,155 community-dwelling respondents. Cox regression determined how the interaction between social isolation and race–ethnicity was associated with incident dementia risk.

Results
Average longitudinal frequency of social isolation was higher among older Black (27.6%), Hispanic (26.6%) and Asian (21.0%) respondents than non-Hispanic White (19.1%) adults during the 11-year period (t = −7.35, p < .001). While a higher frequency of social isolation was significantly associated with an increased (approximately 47%) dementia risk after adjusting for sociodemographic covariates (adjusted hazard ratio [aHR] = 1.47, 95% CI [1.15, 1.88], p < .01), this association was not significant after adjusting for health covariates (aHR = 1.21, 95% CI [0.96, 1.54], p = .11). Race–ethnicity was not a significant moderator in the association between social isolation and dementia.

Conclusions
Older adults from racial-ethnic minoritized populations experienced a higher longitudinal frequency of social isolation. However, race–ethnicity did not moderate the positive association observed between social isolation and dementia. Future research is needed to investigate the underlying mechanisms contributing to racial-ethnic disparities in social isolation and to develop targeted interventions to mitigate the associated dementia risk.
Afterslip and Creep in the Rate‐Dependent Framework: Joint Inversion of Borehole Strain and GNSS Displacements for the Mw 7.1 Ridgecrest Earthquake
Authors: Hanagan C. , Bennett R. A. , Barbour A. , Hughes A. N. 
Published: October 2024

AbstractThe elusive transition toward afterslip following an earthquake is challenging to capture with typical data resolution limits. A dense geodetic network recorded the Mw 7.1 Ridgecrest earthquake, including 16 Global Navigation Satellite System (GNSS) stations and 3 borehole strainmeters (BSM). The sub‐nanostrain precision and sub‐second sampling rate of BSMs bridges a gap between conventional seismologic and geodetic methods, exemplified by atypical postseismic shear strain reversals observed at nearfield (<2 km) station B921 that remain unexplained. We jointly invert GNSS displacements and BSM strains for coseismic and postseismic slip spanning hours to months over 7 independent periods. Cosiesmically, our model resolves the largest slip magnitudes of up to 6.6 m on the mainshock rupture plane, with similar patterns to other inferred slip distributions. The foreshock fault appears to slip coincidently with mainshock, revealing potential asperities activated during the preceding Mw 6.4 event. Postseismically, the best‐fitting models adhere to mechanical rate‐and‐state expectations of logarithmically decaying slip adjacent to the coseismic rupture terminus, and where deep rheologic conditions favor creep. Most spatial variation occurs in the early postseismic timeframe (<1–2 weeks), with evidence for regional rheologic control and static stress dependence. Triggered creep on the neighboring Garlock Fault unexpectedly persists for >178 days—further highlighting the importance of fault networks in postseismic stress redistribution, critical to assessing future hazard.
Differential Phase Analysis for Volcanic Tremor Detection and Source Location
Authors: Barajas Andrés , Shapiro Nikolai M. , Prieto German 
Published: October 2024

AbstractWe present observations showing that during episodes of volcanic tremors, the phase of inter‐station cross‐correlations becomes stable. We propose a new quantity, the phase coherence, to identify the differential phase stability in recordings obtained from a single pair of stations, which is extrapolated to the seismic network. Then, we present a new approach based on the estimation of differential travel times through the differential phase measurements, to locate the sources of tremors occurring at the end of 2015 at the Klyuchevskoy Volcanic Group in Kamchatka, Russia. We present evidence supporting the existence of two types of activity happening simultaneously during the tremor episode: the main tremor source, originating from a region located between 7 and 9 km depth under the main volcanoes, and the widespread occurrence of weak low‐frequency earthquakes occurring at random locations. We show how the phase coherence and the differential phases can be used to provide information on the stability of the tremor source position and to estimate its location.
Pressure Monitoring of Disposal Reservoirs in North‐Central Oklahoma: Implications for Seismicity and Geostorage
Authors: Allen B. , Murray K. , Ogwari P. , Suriamin F. , Walter J. I. , Hayman N. W. 
Published: October 2024

AbstractDisposal of industrial wastewater and activities such as underground sequestration depend upon pressure conditions within deep geologic reservoirs. Sometimes, injection and storage are associated with induced seismicity, suggested to result from reservoir compartmentalization, leakage into faults, or other mechanisms in the subsurface. To understand subsurface pressure conditions within a major regional disposal reservoir, the Arbuckle Group of Oklahoma, we monitored the water levels in 15 inactive injection wells. The wells were monitored at 30‐s intervals, with eight wells monitored since September 2016, and an additional seven from July 2017. All the wells were monitored until early March 2020. Since 2016, hydraulic head decreased in 13 of the 15 wells, proportional to near‐borehole fluid pressure even considering decreasing regional injection volumes during this period. The well pressures respond to three types of perturbations: (i) gravitational fluctuations (a.k.a. solid‐earth tides) (ii) distal and proximal earthquakes, and (iii) injections into nearby wells. Parameterization of tidal responses illustrates that the near wellbore environments have negative fluid flux (i.e., are leaking). Earthquakes cause differing pressure responses from well to well, with some highly sensitive to proximal events, some to distal events, and some apparently insensitive. Injections have variable impacts in some cases masking tidal and earthquake pressure signals. Collectively, there appears to be a threshold injection rate above which well pressure becomes less sensitive to the volume of injections within 15 km. Multi‐scale geological structure and temporal permeability changes are likely controlling the pressure field, indicating leakage of fluids across the system.
Living without pain: A 10-year study of congenital insensitivity to pain with anhidrosis
Authors: klaitman Shai Shlomi , ling Galina , Kristal Eyal , David Odeya , Elamour Siham , Hershkovitz Eli , Ling Eduard 
Published: October 2024

Abstract
Background
Congenital Insensitivity to Pain with Anhidrosis (CIPA) is a rare hereditary neuropathy caused by NTRK1 gene mutations, predisposing patients to recurrent infections and chronic wounds. Long-term studies on microbial and clinical outcomes in CIPA are limited. This study presents analysis of infection patterns, antibiotic resistance, and clinical outcomes in CIPA patients.

Methods
A comprehensive ten-year retrospective cohort study was conducted at Soroka University Medical Center, Beer Sheva, Israel, from January 2014 to January 2023. Electronic medical records were reviewed to identify 63 CIPA patients, all were of consanguineous Bedouin families. Data collection included demographic details, clinical presentations, genetic analysis, documentation of infections, wound sites, hospital duration, and surgical interventions.

Results
Staphylococcus aureus, notably methicillin-resistant, dominated, with Gram-negative bacteria common in lower limbs. The study noted reduced extended-spectrum beta-lactamase bacteria and linked demographic factors to infection traits, antibiotic resistance, and surgical needs.

Conclusion
This study provides valuable insights into the clinical and microbial patterns of CIPA, highlighting dynamic shifts in microbial compositions and antibiotic resistance profiles over time. Staphylococcus aureus, and Gram-negative bacteria particularly in lower limb infections, pose significant challenges in patient management. The findings underscore the importance of tailored approaches to address evolving microbial profiles and optimize patient care in CIPA.

Impact

Key Message: This is the largest cohort study on CIPA to date, highlighting the dominance of Staphylococcus aureus, including methicillin-resistant strains, and significant Gram-negative bacterial infections in lower limbs.

Contribution to Literature: It draws parallels between infection dynamics in CIPA and diabetic foot ulcers, emphasizing similar challenges due to neuropathy and ischemia, enhancing understanding of infection susceptibility and management in neuropathic conditions.

Impact: The findings inform clinical practices by detailing infection and resistance patterns, supporting the development of targeted treatment strategies to improve outcomes for CIPA and similar conditions.
Mechanism of curcumin in the prevention and treatment of oral submucosal fibrosis and progress in clinical application research
Authors: She Rong , Xu Pu 
Published: October 2024

Abstract
Introduction
Oral submucosal fibrosis is a potentially life-threatening oral disease that significantly impacts physiological functions such as speech and swallowing while also diminishing the quality of life for patients. Currently, the mainstream treatment for oral submucosal fibrosis in clinical practice involves invasive glucocorticoid drugs such as injection therapy. However, this method often leads to intraoperative pain, anxiety, fear, and poor medical experience due to associated side effects.

Methods
There is an urgent need to actively explore new drugs and relatively noninvasive approaches for the treatment of oral submucosal fibrosis in order to enhance patients’ medical experience and compliance. This has become a focal point of attention in clinical research. After conducting an extensive literature search, it was discovered that curcumin, a natural polyphenolic compound, exhibits potent anti-tumor, anti-inflammatory, antioxidant, anti-metastatic and anti-angiogenic properties. Moreover, curcumin holds significant clinical potential in the prevention and treatment of various diseases such as oral submucosal fibrosis.

Conclusion
This review presents a comprehensive elaboration encompassing the action mechanisms, biological activity, potential applications, and clinical characteristics of curcumin in the management of oral submucosal fibrosis, aiming to provide diagnostic insights and novel therapeutic perspectives for its prevention and treatment.
One-carbon-mediated purine synthesis underlies temozolomide resistance in glioblastoma
Authors: Ghannad-Zadeh Kimia , Ivanova Alyona , Wu Megan , Wilson Taylor M. , Lau Alyssa , Flick Robert , Munoz David G. , Das Sunit 
Published: October 2024

AbstractGlioblastoma accounts for nearly half of all primary malignant brain tumors in adults, and despite an aggressive standard of care, including excisional surgery and adjuvant chemoradiation, recurrence remains universal, with an overall median survival of 14.6 months. Recent work has revealed the importance of passenger mutations as critical mediators of metabolic adaptation in cancer progression. In our previous work, we identified a role for the epigenetic modifier ID-1 in temozolomide resistance in glioblastoma. Here, we show that ID-1-mediated glioblastoma tumourigenesis is accompanied by upregulation of one-carbon (1-C) mediated de novo purine synthesis. ID-1 knockout results in a significant reduction in the expression of 1-C metabolism and purine synthesis enzymes. Analysis of glioblastoma surgical specimens at initial presentation and recurrence reveals that 1-C purine synthesis metabolic enzymes are enriched in recurrent glioblastoma and that their expression correlates with a shorter time to tumor recurrence. Further, we show that the 1-C metabolic phenotype underlies proliferative capacity and temozolomide resistance in glioblastoma cells. Supplementation with exogenous purines restores proliferation in ID-1-deficient cells, while inhibition of purine synthesis with AICAR sensitizes temozolomide-resistant glioblastoma cells to temozolomide chemotherapy. Our data suggest that the metabolic phenotype observed in treatment-resistant glioma cells is a potential therapeutic target in glioblastoma.
Lyophilised amniotic membrane patches are a safe and effective treatment for rhegmatogenous lesions in combined tractional and rhegmatogenous retinal detachment: a prospective interventional study
Authors: García-Vásquez Ángel , Rojas-Juárez Sergio , Rios-Nequis Geovanni , Ramirez-Estudillo Abel 
Published: October 2024

Abstract

Objectives
This study was performed to evaluate the safety and effectiveness of a lyophilised amniotic membrane (LAM) as a patch for the treatment of retinal breaks and to describe the structural changes at the implantation site.

Design
Prospective, interventional case series study. Patients with diabetic retinopathy and combined tractional and rhegmatogenous retinal detachment.

Methods
Patients were organised into 3 groups according to the number of rhegmatogenous lesions: those in group A had a single break, those in group B had two breaks, and those in group C had three or more breaks. The location of the break was also evaluated as either superior or inferior. Structural outcomes were assessed using SD-OCT during a 3-month follow-up period.

Results
Of a total of 23 eyes of 23 patients, 22 (95.6%) achieved retinal repair without associated complications. Patients with 2 or fewer rhegmatogenous lesions located in the superior sector had a better anatomical result as they achieved 100% surgical success. The structural changes observed by SD-OCT over the follow-up period showed adequate adaptation of the lyophilised patch and complete closure of the rhegmatogenous lesion with no alterations in the adjacent tissue.

Conclusions
The LAM patch seems to be safe and effective, as it promotes therapeutic closure of rhegmatogenous lesions without damaging the retinal architecture adjacent to the implantation site.
Persistence and recurrence after removal of idiopathic epiretinal membrane
Authors: Reichel Felix F. , Labbe Eduardo , Gelisken Faik , Seitz Immanuel P. , Hagazy Sherif , Dimopoulos Spyridon 
Published: October 2024

Abstract

Objectives
To analyse the incidence of persistence and recurrence after the peeling of idiopathic epiretinal membrane (ERM) and to describe its clinical features.

Methods
This retrospective study included 666 eyes (645 patients) that underwent macular surgery for ERM removal. Optical coherence tomographic (OCT) images taken within three months after surgery and at the following visits, clinical parameters and surgery related factors were analysed to investigate the incidence and associated factors of ERM persistence and recurrence. Postoperative ERM types were categorised depending on the size ( < 100 µm, ≥100 µm) and the location (foveal, parafoveal, outside the parafovea)

Results
The mean follow-up time was 29.4 months. ERM persistence (examination within 3 months) was found in 29.6% of all eyes. Only 1.9% of the eyes presented foveal ERM persistence. Foveal recurrence, defined as reappearance or growth of persistent ERM covering the fovea, was found in 8.2%. In 84.4% of eyes with foveal ERM recurrence, postoperative persistence of ERM of varying severity were identified. None of the pre-operative or surgery related factors were found significantly associated with ERM recurrence. Persistent ERM within the parafovea was the most significant risk factor for foveal ERM recurrence.

Conclusion
Recurrence of ERM is generally preceded by the persistence of ERM fragments found in the early postoperative period. Growth of ERM persistence from the parafoveal region was often the origin of foveal ERM recurrence. Insufficient peeling seems to be the most significant predisposing factor for foveal ERM recurrence.
Mouse enteric neurons control intestinal plasmacytoid dendritic cell function via serotonin-HTR7 signaling
Authors: Zhang Hailong , Hasegawa Yuko , Suzuki Masataka , Zhang Ting , Leitner Deborah R. , Jackson Ruaidhrí P. , Waldor Matthew K. 
Published: October 2024

AbstractSerotonergic neurons in the central nervous system control behavior and mood, but knowledge of the roles of serotonergic circuits in the regulation of immune homeostasis is limited. Here, we employ mouse genetics to investigate the functions of enteric serotonergic neurons in the control of immune responses and find that these circuits regulate IgA induction and boost host defense against oral, but not systemic Salmonella Typhimurium infection. Enteric serotonergic neurons promote gut-homing, retention and activation of intestinal plasmacytoid dendritic cells (pDC). Mechanistically, this neuro-immune crosstalk is achieved through a serotonin-5-HT receptor 7 (HTR7) signaling axis that ultimately facilitates the pDC-mediated differentiation of IgA+ B cells from IgD+ precursors in the gut. Single-cell RNA-seq data further reveal novel patterns of bidirectional communication between specific subsets of enteric neurons and lamina propria DC. Our findings thus reveal a close interplay between enteric serotonergic neurons and gut immune homeostasis that enhances mucosal defense.
Enhanced ocean CO2 uptake due to near-surface temperature gradients
Authors: Ford Daniel J. , Shutler Jamie D. , Blanco-Sacristán Javier , Corrigan Sophie , Bell Thomas G. , Yang Mingxi , Kitidis Vassilis , Nightingale Philip D. , Brown Ian , Wimmer Werenfrid , Woolf David K. , Casal Tânia , Donlon Craig , Tilstone Gavin H. , Ashton Ian 
Published: October 2024

AbstractThe ocean annually absorbs about a quarter of all anthropogenic carbon dioxide (CO2) emissions. Global estimates of air–sea CO2 fluxes are typically based on bulk measurements of CO2 in air and seawater and neglect the effects of vertical temperature gradients near the ocean surface. Theoretical and laboratory observations indicate that these gradients alter air–sea CO2 fluxes, because the air–sea CO2 concentration difference is highly temperature sensitive. However, in situ field evidence supporting their effect is so far lacking. Here we present independent direct air–sea CO2 fluxes alongside indirect bulk fluxes collected along repeat transects in the Atlantic Ocean (50° N to 50° S) in 2018 and 2019. We find that accounting for vertical temperature gradients reduces the difference between direct and indirect fluxes from 0.19 mmol m−2 d−1 to 0.08 mmol m−2 d−1 (N = 148). This implies an increase in the Atlantic CO2 sink of ~0.03 PgC yr−1 (~7% of the Atlantic Ocean sink). These field results validate theoretical, modelling and observational-based efforts, all of which predicted that accounting for near-surface temperature gradients would increase estimates of global ocean CO2 uptake. Accounting for this increased ocean uptake will probably require some revision to how global carbon budgets are quantified.
A multiple session dataset of NIRS recordings from stroke patients controlling brain–computer interface
Authors: Isaev Mikhail R. , Mokienko Olesya A. , Lyukmanov Roman Kh. , Ikonnikova Ekaterina S. , Cherkasova Anastasiia N. , Suponeva Natalia A. , Piradov Michael A. , Bobrov Pavel D. 
Published: October 2024

AbstractThis paper presents an open dataset of over 50 hours of near infrared spectroscopy (NIRS) recordings. Fifteen stroke patients completed a total of 237 motor imagery brain–computer interface (BCI) sessions. The BCI was controlled by imagined hand movements; visual feedback was presented based on the real–time data classification results. We provide the experimental records, patient demographic profiles, clinical scores (including ARAT and Fugl–Meyer), online BCI performance, and a simple analysis of hemodynamic response. We assume that this dataset can be useful for evaluating the effectiveness of various near–infrared spectroscopy signal processing and analysis techniques in patients with cerebrovascular accidents.
The impact of education level on all-cause mortality in patients with atrial fibrillation
Authors: Sztaniszláv Áron , Björkenheim Anna , Magnuson Anders , Bryngelsson Ing-Liss , Edvardsson Nils , Poci Dritan 
Published: October 2024

AbstractThe association of socioeconomic status with cardiovascular morbidity and mortality is well known, but data on the influence of education level on mortality in individuals with atrial fibrillation (AF) are scarce. We investigated education level as a predictor of all-cause mortality in patients diagnosed with AF. This retrospective cohort study used a database created from several Swedish nationwide registries to identify all patients hospitalized with a diagnosis of AF hospitalized from 1995 to 2008. Education level was categorized as primary, secondary, and academic. All-cause mortality risk was estimated in subpopulations defined by the Charlson Comorbidity Index and several comorbidities. A total of 272,182 patients (56% male; mean age 72 ± 10 years) were followed for five years. Cox regression models showed a reduction in all-cause mortality risk with increased education level. Hazard ratios (HR) relative to primary education remained significant after stratification and adjustment for several confounders: secondary education HR = 0.88; 95% CI: 0.86–0.89; P < 0.001; academic education HR = 0.70; 95% CI: 0.67–0.72; P < 0.001. Subpopulation analyses confirmed a significant reduction in relative risk with higher education level. Targeted screening and education programs could be effective in reducing mortality in AF patients with fewer years of formal education.