bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolism of bisphenol S in mice after oral administration
Authors: Song Yuanyuan , Xie Peisi , Cai Zongwei 
Published: December 2017

RationaleAs an important substitute of bisphenol A (BPA), bisphenol S (BPS) shows comparable estrogenic effects. BPS is now widely used in consumer products with widespread human exposure. In order to evaluate the health risk of BPS, it is essential to develop a rapid method for the determination of BPS and its metabolites as well as its biotransformation capacity in vivo.MethodsTwo major BPS phase II metabolites, BPS glucuronide (BPS‐G) and BPS sulfate (BPS‐S), were synthesized and used as standards for the development of a ultra‐performance liquid chromatography/electrospray ionization tandem mass spectrometry (UPLC/ESI‐MS/MS) method. Phase II metabolism of BPS in imprinting control region (ICR) female mice after oral administration with different dosages (10, 100, 1000 μg/kg body weight) was investigated.ResultsUrinary elimination was the main excretion route for BPS, with the total recovery ranging from 52.8% to 78.1%. In urine, BPS‐G was identified as the predominant metabolite, and the maximum concentrations of BPS‐G and BPS‐S were obtained at 6 h after the oral administration upon the adjustment by creatinine. BPS was the major compound existed in feces. Only trace amounts of BPS and its metabolites were detected in digestive and excretory related tissues (<1%).ConclusionsThe distribution and metabolic pathway of BPS in mice were assessed. More than 50% of BPS was excreted through phase II metabolism. Due to the biological inactivity of BPS‐G and BPS‐S, rapid metabolism of BPS to BPS‐G and BPS‐S may result in reduced toxicity of BPS in vivo.
High degrees in random recursive trees
Authors: Addario‐Berry Louigi , Eslava Laura 
Published: December 2017

AbstractFor , let Tn be a random recursive tree (RRT) on the vertex set . Let be the degree of vertex v in Tn, that is, the number of children of v in Tn. Devroye and Lu showed that the maximum degree Δn
of Tn satisfies almost surely; Goh and Schmutz showed distributional convergence of along suitable subsequences. In this work we show how a version of Kingman's coalescent can be used to access much finer properties of the degree distribution in Tn. For any , let . Also, let be a Poisson point process on with rate function . We show that, up to lattice effects, the vectors converge weakly in distribution to . We also prove asymptotic normality of when slowly, and obtain precise asymptotics for when and is not too large. Our results recover and extends the previous distributional convergence results on maximal and near‐maximal degrees in RRT.
Control of Target Molecular Recognition in a Small Pore Space with Biomolecule‐Recognition Gating Membrane
Authors: Okuyama Hiroto , Oshiba Yuhei , Ohashi Hidenori , Yamaguchi Takeo 
Published: December 2017

AbstractA biomolecule‐recognition gating membrane, which introduces thermosensitive graft polymer including molecular recognition receptor into porous membrane substrate, can close its pores by recognizing target biomolecule. The present study reports strategies for improving both versatility and sensitivity of the gating membrane. First, the membrane is fabricated by introducing the receptor via a selectively reactive click reaction improving the versatility. Second, the sensitivity of the membrane is enhanced via an active delivering method of the target molecules into the pores. In the method, the tiny signal of the target biomolecule is amplified as obvious pressure change. Furthermore, this offers 15 times higher sensitivity compared to the previously reported passive delivering method (membrane immersion to sample solution) with significantly shorter recognition time. The improvement will aid in applying the gating membrane to membrane sensors in medical fields.
Bioadhesive Polymersome for Localized and Sustained Drug Delivery at Pathological Sites with Harsh Enzymatic and Fluidic Environment via Supramolecular Host–Guest Complexation
Authors: Zhu Meiling , Wei Kongchang , Lin Sien , Chen Xiaoyu , Wu Chia‐Ching , Li Gang , Bian Liming 
Published: December 2017

AbstractTargeted and sustained delivery of drugs to diseased tissues/organs, where body fluid exchange and catabolic activity are substantial, is challenging due to the fast cleansing and degradation of the drugs by these harsh environmental factors. Herein, a multifunctional and bioadhesive polycaprolactone‐β‐cyclodextrin (PCL‐CD) polymersome is developed for localized and sustained co‐delivery of hydrophilic and hydrophobic drug molecules. This PCL‐CD polymersome affords multivalent crosslinking action via surface CD‐mediated host–guest interactions to generate a supramolecular hydrogel that exhibits evident shear thinning and efficient self‐healing behavior. The co‐delivery of small molecule and proteinaceous agents by the encapsulated PCL‐CD polymersomes enhances the differentiation of stem cells seeded in the hydrogel. Furthermore, the PCL‐CD polymersomes are capable of in situ grafting to biological tissues via host–guest complexation between surface CD and native guest groups in the tissue matrix both in vitro and in vivo, thereby effectively extending the retention of loaded cargo in the grafted tissue. It is further demonstrated that the co‐delivery of small molecule and proteinaceous drugs via PCL‐CD polymersomes averts cartilage degeneration in animal osteoarthritic (OA) knee joints, which are known for their biochemically harsh and fluidically dynamic environment.
Aminolated and Thiolated PEG‐Covered Gold Nanoparticles with High Stability and Antiaggregation for Lateral Flow Detection of Bisphenol A
Authors: Lin Li‐Kai , Uzunoglu Aytekin , Stanciu Lia A. 
Published: December 2017

AbstractThe few lateral flow assays (LFAs) established for detecting the endocrine disrupting chemical bisphenol A (BPA) have employed citrate‐stabilized gold nanoparticles (GNPs), which have inevitable limitations and instability issues. To address these limitations, a more stable and more sensitive biosensor is developed by designing strategies for modifying the surfaces of GNPs with polyethylene glycol and then testing their effectiveness and sensitivity toward BPA in an LFA. Without the application of any enhancement strategy, this modified BPA LFA can achieve a naked‐eye limit of detection (LOD) of 0.8 ng mL−1, which is 12.5 times better than the LOD of regular BPA LFAs, and a quantitative LOD of 0.472 ng mL−1. This modified LFA has the potential to be applied to the detection of various antigens.
Issues and Challenges Facing Flexible Lithium‐Ion Batteries for Practical Application
Authors: Cha Hyungyeon , Kim Junhyeok , Lee Yoonji , Cho Jaephil , Park Minjoon 
Published: December 2017

AbstractWith the advent of flexible electronics, lithium‐ion batteries have become a key component of high performance energy storage systems. Thus, considerable effort is made to keep up with the development of flexible lithium‐ion batteries. To date, many researchers have studied newly designed batteries with flexibility, however, there are several significant challenges that need to be overcome, such as degradation of electrodes under external load, poor battery performance, and complicated cell preparation procedures. In addition, an in‐depth understanding of the current challenges for flexible batteries is rarely addressed in a systematical and practical way. Herein, recent progress and current issues of flexible lithium‐ion batteries in terms of battery materials and cell designs are reviewed. A critical overview of important issues and challenges for the practical application of flexible lithium‐ion batteries is also provided. Finally, the strategies are discussed to overcome current limitations of the practical use of flexible lithium‐based batteries, providing a direction for future research.
3D Graphene Encapsulated Hollow CoSnO3 Nanoboxes as a High Initial Coulombic Efficiency and Lithium Storage Capacity Anode
Authors: Huang Jian , Ma Yating , Xie Qingshui , Zheng Hongfei , Yang Jingren , Wang Laisen , Peng Dong‐Liang 
Published: December 2017

Abstract3D Graphene sheets encapsulated amorphous hollow CoSnO3 nanoboxes (H‐CoSnO3@reduced graphene oxide [RGO]) are successfully fabricated by first preparing 3D graphene oxides encapsulated solid CoSn(OH)6 nanocubes, followed by an alkaline etching process and subsequent heating treatment in Ar. The hollow CoSnO3 nanoboxes with average particle size of 230 nm are uniformly and tightly encapsulated by RGO sheets. As an anode material for Li‐ion batteries, H‐CoSnO3@RGO displays high initial Coulombic efficiency of 87.1% and large reversible capacity of 1919 mA h g−1 after 500 cycles at the current density of 500 mA g−1. Moreover, excellent rate capability (1250, 1188, 1141, 1115, 1086, 952, 736, and 528 mA h g−1 at 100, 200, 300, 400, 500, 1000, 2000, and 5000 mA g−1, respectively) is acquired. The reasons for excellent lithium storage properties of H‐CoSnO3@RGO are discussed in detail.
Offshore wind speed estimates from a high‐resolution rapidly updating numerical weather prediction model forecast dataset
Authors: James Eric P. , Benjamin Stanley G. , Marquis Melinda 
Published: December 2017

AbstractIn association with the Department of Energy–funded Position of Offshore Wind Energy Resources (POWER) project, we present results from compositing a 3‐year dataset of 80‐m (above ground level) wind forecasts from the 3‐km High‐Resolution Rapid Refresh (HRRR) model over offshore regions for the contiguous United States. The HRRR numerical weather prediction system runs once an hour and features hourly data assimilation, providing a key advantage over previous model‐based offshore wind datasets. On the basis of 1‐hour forecasts from the HRRR model, we highlight the different climatological regimes of the nearshore environment, characterizing the mean 80‐m wind speed as well as the frequency of exceeding 4, 12, and 25 m s−1 for east and west coast, Gulf of Mexico, and Great Lake locations. Preliminary verification against buoy measurements demonstrates good agreement with observations. This dataset can inform the placement of targeted measurement systems in support of improving resource assessments and wind forecasts to advance offshore wind energy goals both in New England and other coastal regions of the United States.
Spatial and temporal variations in the frequency of thunderstorm days over India
Authors: Singh Omvir , Bhardwaj Pankaj 
Published: December 2017

AbstractThe present study investigates the spatial and temporal variations in the frequency of thunderstorm days over India, based on data from 294 observatory stations for four overlapping 30‐year time periods: 1951–1980, 1961–1990, 1971–2000 and 1981–2010. Analysis of the data revealed a significant decreasing trend in thunderstorm frequency over India. Relative to the 1951–1980 time period, there has been a net decrease of 34% in the frequency of thunderstorm days during the 1981–2010 period. Seasonal analysis confirms, unsurprisingly, that the maximum thunderstorm frequency occurs during monsoon season (June–September), with the lowest frequency occurring over the winter season (January–February). June is the month with the highest number of thunderstorm days, while December has the lowest. The greatest number of thunderstorms is observed over northeastern India, and the smallest number in the western parts of the country. Regional investigations show a wide variability in the occurrence of thunderstorms over space and time. The frequency of thunderstorm days over the mountains is much higher than over the plains at the same latitude.
Emerging roles of RNA‐binding proteins in diabetes and their therapeutic potential in diabetic complications
Authors: Nutter Curtis A. , Kuyumcu‐Martinez Muge N. 
Published: December 2017

Diabetes is a debilitating health care problem affecting 422 million people around the world. Diabetic patients suffer from multisystemic complications that can cause mortality and morbidity. Recent advancements in high‐throughput next‐generation RNA‐sequencing and computational algorithms led to the discovery of aberrant posttranscriptional gene regulatory programs in diabetes. However, very little is known about how these regulatory programs are mis‐regulated in diabetes. RNA‐binding proteins (RBPs) are important regulators of posttranscriptional RNA networks, which are also dysregulated in diabetes. Human genetic studies provide new evidence that polymorphisms and mutations in RBPs are linked to diabetes. Therefore, we will discuss the emerging roles of RBPs in abnormal posttranscriptional gene expression in diabetes. Questions that will be addressed are: Which posttranscriptional mechanisms are disrupted in diabetes? Which RBPs are responsible for such changes under diabetic conditions? How are RBPs altered in diabetes? How does dysregulation of RBPs contribute to diabetes? Can we target RBPs using RNA‐based methods to restore gene expression profiles in diabetic patients? Studying the evolving roles of RBPs in diabetes is critical not only for a comprehensive understanding of diabetes pathogenesis but also to design RNA‐based therapeutic approaches for diabetic complications. WIREs RNA 2018, 9:e1459. doi: 10.1002/wrna.1459This article is categorized under:

RNA in Disease and Development > RNA in Disease
RNA Processing > Splicing Regulation/Alternative Splicing
Translation > Translation Regulation
Impact of the Weekday of Surgery on Outcome in Gastric Cancer Patients who Underwent D2‐Gastrectomy
Authors: Berlth Felix , Messerle K. , Plum P. S. , Chon S.‐H. , von Ambüren J. , Hohn A. , Dübbers M. , Bruns C. J. , Mönig S. P. , Bollschweiler E. , Hölscher A. H. , Alakus H. 
Published: December 2017

AbstractBackgroundThe impact of the weekday of surgery in major elective cases of the upper‐GI has been discussed controversially. The objective of this study was to assess whether weekday of surgery influences outcome in patients undergoing D2‐gastrectomy.
Materials and methodsPatients who underwent D2‐gastrectomy for gastric adenocarcinoma between 1996 and 2016 were included. Weekday of surgery was recognized, and subgroups were analyzed regarding clinical and histopathological differences. Survival analysis was performed based on weekday of surgery, and early weekdays (Monday–Tuesday) were compared with late weekdays (Wednesday–Friday).
ResultsIn total, 460 patients, 71% male and 29% female, were included into analysis. The median age was 65 years. Distribution to each weekday was equal and ranged from 86 cases (Wednesday) to 96 cases (Tuesday). The pT, pN and M category and the rate of patients who underwent neoadjuvant treatment did not show significant differences (p = 0.641; p = 0.337; p = 0.752; p = 0.342, respectively). The subgroups did not differ regarding the number of dissected lymph nodes and rate of R‐1/2 resections (p = 0.590; p = 0.241, respectively). Survival analysis showed a median survival of 43 months (95% CI 31–55 months), and there was no single weekday or a combination of weekdays (Mon/Tue vs Wed/Thu/Fri) with a significant favorable or worse outcome (p = 0.863; p = 0.30, respectively). The outcome did not differ regarding mortality within the first 90 days after surgery (p = 0.948).ConclusionsThe present study does not show any evidence for a significant impact of weekday of surgery on short‐ and long‐term outcome of patients undergoing gastrectomy for gastric adenocarcinoma.
Predicted Coronary Heart Disease Risk Decreases in Obese Patients After Laparoscopic Sleeve Gastrectomy
Authors: Huang Cheng‐Chiao , Wang Weu , Chen Ray‐Jade , Wei Po‐Li , Tzao Ching , Chen Ping‐Ling 
Published: December 2017

AbstractPurposeTo assess the reduction of 6 and 12 months postoperatively of Framingham risk score in morbidly obese patients with laparoscopic sleeve gastrectomy (LSG).Material and methodsIn total, 870 morbid obesity patients received LSG in Taipei Medical University Hospital from June 2007 to June 2014 were retrospectively studied preoperatively, 6 and 12 months after surgery. The coronary heart disease risk was calculated using Framingham risk score.ResultsThe body mass index in men and women decreased from 43.3 ± 6.9, 39.2 ± 6.0 kg/m2 preoperatively to 32.9 ± 6.7, 31.0 ± 5.2 kg/m2 and to 30.4 ± 5.6, 28.2 ± 4.7 kg/m2, respectively, at 6 and 12 months after surgery (P < 0.0001). At 6 and 12 months after LSG, there was a marked improvement on lipid profile as well as a significant decline in the prevalence of diabetes mellitus, systemic hypertension, and smoking. The Framingham risk score in men and women reduced from 3.2 ± 5.7, 6.1 ± 5.7 preoperatively to 1.4 ± 5.9, 3.3 ± 5.9 and 0.1 ± 6.2, 2.8 ± 6.1, respectively, at 6 and 12 months after surgery (P < 0.0001).ConclusionsLaparoscopic sleeve gastrectomy is efficient not only in the reduction of obesity and its related comorbidities but also in decreasing the long‐term coronary event risk. Early intervention for the high‐risk group is strongly recommended.
Endoscopic full-thickness resection of gastric and duodenal subepithelial lesions using a new, flat-based over-the-scope clip
Authors: Kappelle Wouter F. W. , Backes Yara , Valk Gerlof D. , Moons Leon M. G. , Vleggaar Frank P. 
Published: December 2017

Abstract
Background
Surgical resection of upper gastrointestinal (GI) subepithelial tumors (SETs) is associated with significant morbidity and mortality. A new over-the-scope (OTS) clip can be used for endoscopic full-thickness resection (eFTR). We aimed to prospectively evaluate feasibility and safety of upper GI eFTR with a new, flat-based OTS clip.

Methods
Consecutive patients with a gastric or duodenal SET < 20 mm were prospectively included. After identification of the lesion, the clip was placed and lesions were resected. Patients were followed for 1 month to assess severe adverse events (SAEs); 3–6 months after eFTR, endoscopy was performed.

Results
eFTR was performed on 13 lesions in 12 patients: 7 gastric and 6 duodenal SETs. Technical success was achieved in 11 cases (85%). In all 11 cases, R0-resection was achieved. In all 6 duodenal cases and in one gastric case, FTR was achieved (64%). One SAE (pain) was observed after eFTR of a gastric SET. After eFTR of duodenal SETs, several SAEs were observed: perforation (n = 1), microperforation (n = 3), and hemorrhage (n = 1). During follow-up endoscopy, the clip was no longer in situ in most patients (7 of 10; 70%).

Conclusions
eFTR with this new flat-based OTS clip is feasible and effective. Although gastric eFTR was safe, eFTR in the duodenum was complicated by (micro)perforation in several patients. Therefore, the design of the clip or the technique of resection needs further refinement to improve safety of resection of SET in thin-walled areas such as the duodenum before being applied in clinical practice.
Dutch trial register: NTR5023.
Growth responses of Canada goldenrod (Solidago canadensis L.) to increased nitrogen supply correlate with bioavailability of insoluble phosphorus source
Authors: Wan Ling‐Yun , Qi Shan‐Shan , Dai Zhi‐Cong , Zou Chris B. , Song Yi‐Ge , Hu Zhi‐Yuan , Zhu Bin , Du Dao‐Lin 
Published: December 2017

AbstractAnthropogenic nitrogen (N) inputs lead to the increase of phosphorus (P) demand for plants and plant species competition in a N enriched environment may hinge on its ability to utilize soil P sources. In soils, P mostly exists as insoluble phosphate compounds with three mineral elements: iron (Fe), aluminum (Al) or calcium (Ca), and it remains largely unknown whether invasive plant species are able to access such insoluble P sources and its interaction with N enrichment to gain competitive advantage. We determined the morphological traits, growth and nutrient status of an invasive plant Canada goldenrod (Solidago canadensis L.) cultured in soluble phosphate KH2PO4 (Ortho‐P), and insoluble inorganic phosphate AlPO4 (Al–P), FePO4 (Fe–P), Ca5(OH)(PO4)3 (Ca–P) at three N supply levels. Results showed that S. canadensis was able to selectively utilize P from Al–P but not from Fe–P or Ca–P by increasing root number and length under N additions. The increasing growth in S. canadensis was closely correlated with the increasing foliar P. Ability to utilize insoluble P sources under enriched N environment serves as a competitive advantage for S. canadensis in Al rich soils. Effective control of S. canadensis invasion may need to consider soil P management in the context of atmospheric N deposition as well.
Distribution breadth and species turnover of night‐flying beetles and moths on different mainland and island mountains
Authors: Choi Sei‐Woong , Thein Pyae Pyae 
Published: December 2017

AbstractDistribution breadth and species turnover rates of two night‐flying insect groups (moths and beetles) were analyzed on two mountains in warm temperate forests of South Korea, Mt. Hallasan (range 278–1109 m) on Jejudo island (HL) and Mt. Jirisan (range 319–1330 m) in southern Korea (JR). The goals of the study were to compare the spatial changes in the two insect groups on both mountains and to identify ecological factors influencing the diversity pattern. Insects were collected from 16 sites in two mountains from May to October of 2013 and 2014 using a UV light trap. Moths were generally more diverse on JR than on HL, but similarity among sites was higher on JR than on HL. However, beetles were not different between the two mountains in diversity and similarity of assemblages among sites. The distributional range of both moths and beetles were significantly narrower on HL than JR, while the distributional range curves peaked at mid‐elevations, being positively skewed at HL and negatively skewed at JR. Whittaker's species turnover rates of moths and beetles were higher for HL than JR. On both mountains, latitude was a significant variable influencing moth species richness and abundance, while soil fertility and plant species richness were significant variables influencing beetle abundance. Geographic distance and elevation played a significant role in segregating insect assemblages on both mountains, except for moths in JR. The pattern and mechanism of spatial changes in night‐flying insect assemblages on both mountains varied depending on insect group and location.