bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and evaluation of an 18F‐labeled trifluoroborate derivative of 2‐nitroimidazole for imaging tumor hypoxia with positron emission tomography
Authors: Nunes Paulo Sérgio Gonçalves , Zhang Zhengxing , Kuo Hsiou‐Ting , Zhang Chengcheng , Rousseau Julie , Rousseau Etienne , Lau Joseph , Kwon Daniel , Carvalho Ivone , Bénard François , Lin Kuo‐Shyan 
Published: December 2017

Abstract2‐Nitroimidazole‐based hypoxia imaging tracers such as 18F‐FMISO are normally imaged at late time points (several hours post‐injection) due to their slow clearance from background tissues. Here, we investigated if a hydrophilic zwitterion‐based ammoniomethyl‐trifluoroborate derivative of 2‐nitroimidazole, 18F‐AmBF3‐Bu‐2NI, could have the potential to image tumor hypoxia at earlier time points. AmBF3‐Bu‐2NI was prepared in 4 steps. 18F labeling was conducted via 18F‐19F isotope exchange reaction, and 18F‐AmBF3‐Bu‐2NI was obtained in 14.8 ± 0.4% (n = 3) decay‐corrected radiochemical yield with 24.5 ± 5.2 GBq/μmol specific activity and >99% radiochemical purity. Imaging and biodistribution studies in HT‐29 tumor‐bearing mice showed that 18F‐AmBF3‐Bu‐2NI cleared quickly from blood and was excreted via the hepatobiliary and renal pathways. However, the tumor was not visualized in PET images until 3 hours post‐injection due to low tumor uptake (0.54 ± 0.13 and 0.19 ± 0.04%ID/g at 1 and 3 hours post‐injection, respectively). The low tumor uptake is likely due to the highly hydrophilic motif of ammoniomethyl‐trifluoroborate that prevents free diffusion of 18F‐AmBF3‐Bu‐2NI across the cell membrane. Our results suggest that highly hydrophilic 18F‐labeled ammoniomethyl‐trifluoroborate derivatives might not be suitable for imaging intracellular targets including nitroreductase, a common tumor hypoxia imaging target.
Simultaneous acquisition of MR angiography and diagnostic images of abdomen at view‐sharing multiarterial phases and comparing the effect of two different contrast agents
Authors: Noda Yoshifumi , Goshima Satoshi , Namimoto Tomohiro , Shinkawa Norihiro , Nakagawa Masataka , Kajita Kimihiro , Kawada Hiroshi , Kawai Nobuyuki , Tanahashi Yukichi , Matsuo Masayuki , Bae Kyongtae T , Hirai Toshinori , Yamashita Yasuyuki 
Published: December 2017

BackgroundSimultaneous acquisition of magnetic resonance angiography (MRA) and diagnostic images is challenging in contrast‐enhanced upper abdominal MRI.PurposeTo evaluate the image quality of MRA of the abdomen acquired simultaneously with diagnostic MR images, and to compare the contrast effect, conspicuity of aortic branches, and pancreatic lesions in MRA between gadobutrol and gadoterate meglumine.Study TypeProspective.PopulationEighty‐eight patients with known and suspected upper abdominal disease.Field Strength/Sequences3T/4D‐eTHRIVE (T1‐weighted fat‐suppressed 3D fast gradient echo) for multiarterial phase imaging.AssessmentThe artery‐to‐muscle signal intensity ratio (SIR), conspicuity of aortic branches on the axial, maximum intensity projection (MIP), and volume‐rendered (VR) images, and conspicuity of focal pancreatic lesions were compared between gadobutrol and gadoterate meglumine. The diameters of aortic branches were measured on axial MRA and computed tomography angiography (CTA) images and then compared.Statistical TestsQuantitative and qualitative data were assessed with the Mann–Whitney U‐test. The diameters of aortic branches between MRA and CTA were compared with a Spearman rank correlation test.ResultsView‐sharing multiarterial phase imaging was successfully performed in all patients. The SIRs of common hepatic artery (P = 0.0051) and left renal artery (RA) (P = 0.045), vascular conspicuities of right and left hepatic arteries (P = 0.010 and 0.030) and right and left RAs on axial (P = 0.0065 and 0.036), and that of gastroduodenal artery on MIP (P = 0.039) with gadobutrol were significantly higher than those with gadoterate meglumine. The conspicuity of focal pancreatic lesions were comparable between the gadobutrol and gadoterate meglumine (P = 0.73). The vascular diameters on MRA and CTA were strongly correlated in all aortic branches (r = 0.842–0.942, P < 0.0001).Data ConclusionHigh‐quality MRA of the abdomen was obtained simultaneously with the diagnostic MR images using view‐sharing multiarterial phase imaging that also demonstrated comparable image quality between gadobutrol and gadoterate meglumine.Level of Evidence: 2Technical Efficacy Stage 1J. Magn. Reson. Imaging 2017.
Igniting and resolving content disagreements during team interactions: A statistical discourse analysis of team dynamics at work
Authors: Lehmann‐Willenbrock Nale , Chiu Ming Ming 
Published: December 2017

SummaryDisagreements are integral to fruitful team collaboration but have rarely been studied within actual team interactions. We develop a temporal account of how disagreement episodes begin and are resolved during team interactions, testing explanatory factors at multiple levels: team context (team conflict states and team productivity), individual characteristics and perceptions (individual status and perceptions of team viability), and behavioral patterns (problem solving versus off‐task communication) with a statistical discourse analysis of 32,448 turns of talk by 259 employees during 43 team meetings. As hypothesized, problem‐solving behaviors (e.g., describing problems and proposing solutions) ignited content disagreements, often by participants who perceived greater team viability. In contrast, after off‐task behaviors or talk by higher status team members, participants started fewer content disagreements. Moreover, content disagreements started by higher status individuals were more likely than those started by others to be resolved with agreements, especially via agreements with higher status individuals. Also, problem‐solving behaviors facilitated the resolution of disagreement episodes with agreement, whereas off‐task behaviors hindered them. Contrary to our hypotheses, team conflict states and productivity were not linked to starting or ending disagreements. We discuss the conceptual and methodological importance of capturing team interaction dynamics at work and derive practical implications for managing content disagreement.
Dispersion and isogeometric analyses of second‐order and fourth‐order implicit gradient‐enhanced plasticity models
Authors: Kolo Isa , de Borst René 
Published: December 2017

SummaryImplicit gradient plasticity models incorporate higher‐order spatial gradients via an additional Helmholtz type equation for the plastic multiplier. So far, the enrichment has been limited to second‐order spatial gradients, resulting in a formulation that can be discretised using
‐continuous finite elements. Herein, an implicit gradient plasticity model is formulated that includes a fourth‐order gradient term as well. A comparison between the localisation properties of both the implicit gradient plasticity formulations and the explicit second‐order gradient plasticity model is made using a dispersion analysis. The higher‐order continuity requirement for the fourth‐order implicit gradient plasticity model has been met by exploiting the higher‐order continuity property of isogeometric analysis, which uses nonuniform rational B‐splines as shape functions instead of Lagrange polynomials. The discretised variables, displacements, and plastic multiplier may require different orders of interpolation, an issue that is also addressed. Numerical results show that both formulations can be used as a localisation limiter, but that quantitative differences occur, and a different evolution of the localisation band is obtained for 2‐dimensional problems.
Predictors of adherence to exercise interventions during and after cancer treatment: A systematic review
Authors: Ormel H.L. , van der Schoot G.G.F. , Sluiter W.J. , Jalving M. , Gietema J.A. , Walenkamp A.M.E. 
Published: December 2017

AbstractObjectiveExercise interventions benefit cancer patients. However, only low numbers of patients adhere to these interventions. This review aimed to identify predictors of exercise intervention adherence in patients with cancer, during and after multimodality cancer treatment.MethodsA literature search was performed using electronic databases (PubMed, Embase, and Cochrane) to identify relevant papers published before February 1, 2017. Papers reporting randomized controlled trials, conducted in adult cancer patients who participated in an exercise intervention during and/or after multimodality cancer treatment, and providing outcome of factors predicting exercise adherence were included. Papers were assessed for methodological quality by using the Physiotherapy Evidence Database scale.ResultsThe search identified 720 potentially relevant papers, of which 15 fulfilled the eligibility criteria. In these 15 studies, 2279 patients were included and 1383 of these patients were randomized to an exercise intervention. During cancer treatment, the factors predicting exercise adherence were as follows: location of the rehabilitation center, extensive exercise history, high motivation for exercise, and fewer exercise limitations. After cancer treatment, factors that predicted adherence were as follows: less extensive surgery, low alcohol consumption, high previous exercise adherence, family support, feedback by trainers, and knowledge and skills of exercise. Methodological quality of the included papers was rated “high”.ConclusionsThe most prominent predictors of adherence to exercise interventions were location of the rehabilitation center, extensive exercise history, high motivation for exercise, and fewer exercise limitations. To increase the number of cancer patients who will benefit, these results should be considered into the development and implementation of future exercise interventions.
Antiinflammatory properties of betulinic acid and xylopic acid in the carrageenan‐induced pleurisy model of lung inflammation in mice
Authors: Ekuadzi Edmund , Biney Robert P. , Benneh Charles K. , Osei Amankwaa Bismark , Jato Jonathan 
Published: December 2017

This study investigated the antiinflammatory properties of betulinic acid (BA) and xylopic acid (XA) extracted from Margaritaria discoidea and Xylopia aethiopica, respectively. M. discoidea and X. aethiopica are plants native in Ghana and the West‐African region and used traditionally to treat different pathologies including inflammatory conditions. The antiinflammatory effect of BA and XA was established by an in vivo assay using the carrageenan‐induced pleural inflammation model in mice. Also, the ability of BA and XA to increase catalase, superoxide dismutase, glutathione levels and decrease lipid peroxidation level in reactive oxidative assays was assessed. In addition, the ability of XA and BA to prevent potential lung tissue damage was quantified. Pretreatment with BA and XA reduced significantly, signs of inflammation: neutrophil infiltration, oedema, and alveoli septal thickening in carrageenan‐treated lung tissue. Additionally, BA or XA pretreatment lowered the degree of lipid peroxidation in the lung tissue while increasing the levels of catalase, superoxide dismutase, and glutathione in vivo. Comparatively, XA was more efficacious than BA in the prevention of lung tissue damage. BA and XA derived from X. aethiopica and M. discoidea possess antiinflammatory and in vivo antioxidant activities in mice pleurisy model. The effect of these compounds gives credence to the traditional use in the management of inflammatory conditions of the airway.
Western herbal medicine consultations for common menstrual problems; practitioner experiences and perceptions of treatment
Authors: Fisher Carole , Adams Jon , Frawley Jane , Hickman Louise , Sibbritt David 
Published: December 2017

To explore the prevalence with which Australian Western herbalists treat menstrual problems and their related treatment, experiences, perceptions, and interreferral practices with other health practitioners. Members of the Practitioner Research and Collaboration Initiative practice‐based research network identifying as Western Herbalists (WHs) completed a specifically developed, online questionnaire. Western Herbalists regularly treat menstrual problems, perceiving high, though differential, levels of effectiveness. For menstrual problems, WHs predominantly prescribe individualised formulas including core herbs, such as Vitex agnus‐castus, and problem‐specific herbs. Estimated clients' weekly cost (median = $25.00) and treatment duration (median = 4–6 months) covering this Western herbal medicine treatment appears relatively low. Urban‐based women are more likely than those rurally based to have used conventional treatment for their menstrual problems before consulting WHs (p = .001). Only 19% of WHs indicated direct contact by conventional medical practitioners regarding treatment of clients' menstrual problems despite 42% indicating clients' conventional practitioners recommended consultation with WH. Western herbal medicine may be a substantially prevalent, cost‐effective treatment option amongst women with menstrual problems. A detailed examination of the behaviour of women with menstrual problems who seek and use Western herbal medicine warrants attention to ensure this healthcare option is safe, effective, and appropriately co‐ordinated within women's wider healthcare use.
Cover Image, Volume 10, Issue 1
Authors: Rinaldi Gianmarco , Rossi Matteo , Fendt Sarah‐Maria 
Published: December 2017

The cover image, by Gianmarco Rinaldi et al., is based on Advanced Review Metabolic interactions in cancer: cellular metabolism at the interface between the microenvironment, the cancer cell phenotype and the epigenetic landscape, DOI: 10.1002/wsbm.1397.
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Control of Resistant Colorado Potato Beetle in Early Market Potato, Big Lake, Mn, 1993
Authors: Noetzle David , Miller Jennifer 
Published: December 2017

Abstract
Continued failure of most insecticides for control of CPB in the Anoka Sand Plains growing area stimulated further comparisons of biologicals, inorganics, and synthetic materials for CPB management. Soils are sands at this location. Plots were established in an irrigated commercial potato field. The individual plot consisted of 4—25 ft rows with a row width of 3 ft. Treatments were arranged in a randomized complete block design and were replicated 4 times. The grower treated all of the field, including the plots, with Thiodan and Asana XL at 1.0 lb and 0.5 lb Al/acre respectively on 8 Jul and 16 Jul. Plot treatments were applied on 25 Jun, 6 and 19 Jul using a CO2 hand sprayer with about 20 gals total material/acre and 40 psi pressure. Larval ratings and defoliation estimates were taken on 6 and 19 Jul. Vines were killed on 3 Aug and yields collected on 18 Aug. The center 2 rows of each plot were harvested for yield.
Potato Insect Control, 1991
Authors: Slocombe A. C. , Ferro D. N. 
Published: December 2017

Abstract
Potatoes were planted on 7 May in South Deerfield, Massachusetts. Fertilizer (900 lbs 10N:10P:10K/ acre) was banded into the furrow at planting. Soil type was a fine sandy loam with a pH of 5.6. Manzate (fungicide) was applied at 1 lb. Al/acre on 14, 21, and 28 Jun and 11 and 18 Jul. CPB densities prior to first application were 2.9 adults, 8.2 egg masses, 16.3 early instars and 0.8 late instars per plant on 10 Jun. Treatments were replicated 4 times in a randomized complete block design. Each plot consisted of two 30 ft. rows with a 6 ft. fallow area between plots. Treatments were applied with CO2-pressurized sprayers at 40 psi, delivering 70 gal/acre. Applications were made on 10, 17, and 24 Jun and 1 and 10 Jul. The first application of ECX9124EH was on 10 Jun followed by weekly applications of M-Trak. CPB population densities were determined by counting larvae on 10 whole stalks in each plot. To evaluate microbial insecticides M-Trak, M-One, Trident II, and Foil OF, larvae were counted and recorded as early instars (first and second) or late instars (third and fourth). The performance of these materials was evaluated primarily by comparing late instars, as it took 4-5 days for the dead larvae to drop from the plants and early instars could have hatched between the last spray and the following count. The control plots were 70% defoliated when they were plowed under on 3 Jul.
Use of Furadan 4F for Striped Cucumber Beetle Control in Yellow Squash, Spring, 1993
Authors: Speese John 
Published: December 2017

Abstract
Squash was planted on 10 Jun at the Eastern Shore Agricultural Experiment Station, Painter, VA. Each plot consisted of a 25 ft row bordered on each side by an untreated guard row, with 5 ft row spacing. Plots were replicated 4 times in a randomized complete block design. Furadan 4F treatments were applied with a single nozzle boom backpack sprayer in furrow immediately prior to planting. Foliar sprays were applied on the dates indicated in the table in 45 gal water/acre at 40 psi. A single nozzle boom was used for the first spray, and a three nozzle boom for subsequent sprays after the plants had begun to fill in between the rows. Evaluation criteria consisted of insect counts on 6 ft of row and ratings of percent defoliation. The fruit was harvested from 5 marked plants in each plot on 19, 22, 27, and 30 Jul. SCB was the dominant insect species present, with low numbers of spotted cucumber beetle and squash bug also present.
Armyworm and Tomato Pinworm Control on Fresh Market Tomatoes in West-Central Florida, Fall 1992
Authors: Schuster David J. 
Published: December 2017

Abstract
Transplants were set 2 Sep, 15 inches apart on 8-inch-high beds of EauGallie fine sand covered with white polyethylene mulch. Each plot consisted of a single 15 ft row with rows on 5 ft centers. Treatments were replicated 4 times in a randomized complete block design and were applied with a 2.5 gal, hand-held CO2-powered sprayer on 1,9, 16, 22, 29 Oct, 5 and 26 Nov. Applications were not made the weeks of 9 and 16 Nov because of inclement weather. The sprayer was operated at 60 psi and delivered 60 gpa for the first three applications and 120 gpa for the remaining applications using a single nozzle fitted with a D-5 disk and #45 core. On 20 Nov, the numbers of large (0.5 inch) and small (&lt;0.5 inch) southern armyworm larvae per plot were determined by a whole plant search. Fruit were harvested on 25 Nov and 9 Dec. The number and weight of undamaged fruit and the number and weight of fruit damaged by armyworm and tomato pinworm larvae were determined.
Foliar Sprays for Insect Control in Tomatoes, 1993
Authors: Speese John 
Published: December 2017

Abstract
Tomatoes were transplanted on 23 Jul at the Eastern Shore Agricultural Experiment Station, Painter, VA. Each plot consisted of a 25 ft. row, bordered on each side by an untreated guard row, and replicated 4 times in a randomized, complete block design. Spacing was 5 ft. between rows. Sprays were applied weekly beginning 20 Aug through 23 Sep using a 3 nozzle hollow cone boom backpack sprayer delivering 45 gal water/acre at 40 psi. Evaluation criteria consisted of counts of new or living leaf mines present on five marked plants/plot on the dates indicated in the table, and number of marketable fruit from the same five plants harvested on 8 and 22 Sep.
Evaluation of Selected Insecticides for Control of Onion Thrips on Onions, 1993
Authors: Sparks Alton N. , Riley David G. 
Published: December 2017

Abstract
A small plot test was conducted at the Texas A&M Research and Extension Center in Weslaco, Texas, to evaluate selected insecticides for control of onion thrips on onions. Experimental plots measured one row (40 in.) by 25 ft, with two border rows between plots. Treatments were arranged in a randomized complete block design with four replications. Insecticides were applied with a CO2 pressurized backpack sprayer at 40 psi in a total volume of 25 gal per acre. Nozzles were arranged with two 10X nozzles per row (over-top). Applications were made on 9, 12 and 20 Feb. Thrips populations were monitored by counting all thrips present on each of five randomly selected plants per plot.
Potato Leafhopper Control, 1993
Authors: McLeod M. J. , Twidwell E. K. , Gallenberg D. J. , Voss T. S. 
Published: December 2017

Abstract
Evaluation of several insecticide against potato leafhopper infesting alfalfa were made at 2 locations in SD, Beresford and Brookings. Plots were 30 ft × 30 ft. All treatments and the untreated check were replicated 4 times in a RCBD. Insecticides were applied in a final spray volume of 20 gal per acre at 35 psi using a hand-held sprayboom consisting of 4, 8002S nozzles on 19 inch centers. Applications were made on 22 Jul at Beresford and 31 Aug at Brookings. Early harvest was made on the day of insecticide application at both locations. Potato leafhopper populations were monitored by taking 10 sweeps per plot with a standard 15 inch diam net prior to application and at 4, 7, 10, and 14 DAT at Beresford. At Brookings, samples were obtained 1 d before and 1, 4, 7, 10 and 14 DAT. Yield was obtained from a 45 ft2 area in the center of each plot 14 DAT for each experiment.
Late Season Insect Control in Canola, 1993A
Authors: McCaffrey J. P. , Harmon B. L. 
Published: December 2017

Abstract
A large block was seeded on 7 inch centers at 7 lb/acre using a plot drill on 11 May at the University of Idaho Plant Science Farm in Moscow, ID. Individual 12 × 23 ft plots were later tilled-out of the block. Insecticide treatments were arranged in a RCBD with 4 replications each. Treatments were applied on 27 Jul when about 10% of the plants were still in bloom. Temperatures at the time of spray application were 82°F. Insecticides were applied using a CO2-pressurized backpack sprayer equipped with 80° fan nozzles on a 6-ft boom that delivered 20 gal/acre at 20 psi. Pretreatment and posttreatment counts of DBM were made by dislodging larvae into a 5 gal plastic bucket with a beat of the hand at each end of the plot. The proportion of aphid-infested canola terminals was assessed by randomly selecting 50 terminals in each plot and recording the presence or absence of aphids. Plot yields were obtained by making one pass along the center of each plot with a smallplot combine (4.6 ft header). Seed was cleaned and weighed. All data were subjected to analysis of variance and protected LSD tests.