bluuebunny/crossref_metadata_2025_split huggingface dataset:
UJI AKTIVITAS SITOTOKSIK EKSTRAK ETIL ASETAT DAUN ALPUKAT (Persea americana Mill)
Authors: Aulia Bakhtra Dwi Dinni , Fajrina Anzharni , Wiliantari Selvia , Puspitasari Meike 
Published: September 2024

Tanaman alpukat (Persea americana Mill) merupakan salah satu jenis tanaman yang banyak digunakan sebagai obat tradisional. Daun alpukat menghasilkan senyawa metabolit sekunder yang berpotensi untuk dikembangkan sebagai obat antikanker dan aktivitas antioksidan. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak etil asetat daun alpukat terhadap sel kultur HeLa dan menentukan aktivitas sitotoksiknya. Penelitian ini menggunakan pelarut etil asetat untuk mengekstraksi daun alpukat dan pengujian aktivitas sitotoksik menggunakan metode Microculture tetrazolium test dengan berbagai variasi konsentrasi uji. Dari hasil penelitian, ekstrak etil asetat daun alpukat mempengaruhi pertumbuhan sel HeLa, peningkatan konsentrasi menurunkan persentase viabilitas sel HeLa. Dari hasil pengujian, ekstrak etil asetat daun alpukat memiliki aktivitas sitotoksik yang berada dalam kategori toksik dengan nilai IC50 139,2515 μg/mL. Dari hasil penelitian dapat disimpulkan bahwa ekstrak etil asetat daun alpukat dapat mempengaruhi pertumbuhan sel dan memiliki aktivitas sitotoksik terhadap sel HeLa
Identification and validation of autophagy-related genes and exploration of their relationship with disease severity in chronic rhinosinusitis with nasal polyps
Authors: Zi Jiajia , Yu Longgang , Wang Lin , Yan Xudong , Li Danyang , Du Xiaoyun , Zhang Jisheng , Jiang Yan 
Published: September 2024

Background:
Chronic rhinosinusitis with nasal polyps (CRSwNP) pathogenesis might be impacted by autophagy. Nevertheless, autophagy-related gene utilization as a disease indicator about the course of CRSwNP has yet to be elucidated.

Objective:
This investigation aimed at discovering pivotal molecules related to autophagy to identify potential treatment targets for CRSwNP.

Methods:
The dataset GSE136825 was obtained via the Gene Expression Omnibus (GEO) database, and afterward, differentially expressed genes (DEGs) analysis linked to autophagy was employed via the R software. A comprehensive examination of autophagy-related DEGs was conducted using functional analytic techniques. The utilization of the protein-protein interaction (PPI) network facilitated hub gene identification. Quantitative real-time polymerase chain reaction (qRT-PCR), western blot, and immunohistochemistry staining techniques were performed to validate the expression levels of the central genes in clinical samples. Correlation analysis was performed to examine the correlation between hub genes and disease severity parameters.

Results:
A comprehensive set of 86 autophagy-related DEGs were discovered. The functional enrichment analysis of autophagy-related DEGs revealed the identification of enrichment terms involved with the autophagy process. The results obtained from the PPI analysis suggest that there was interaction among the autophagy-related genes. The qRT-PCR, immunohistochemistry staining, and western blot techniques yielded results, demonstrated that CXCR4, HMOX1, and SPP1 expression levels in CRSwNP agreed with the bioinformatics analysis of the dataset. Furthermore, a favorable association between CXCR4, HMOX1, and SPP1 expression levels with illness severity indicators was found.

Conclusion:
Bioinformatics analysis yielded 86 autophagy-related DEGs in CRSwNP. CXCR4, HMOX1, and SPP1 regulation of autophagy has been confirmed in CRSwNP progression and pathogenesis.
Factors associated with computational thinking skills among colleges in the university
Authors: Tarigan Wenny Pinta Litna , Paidi  , Wiyarsi Antuni , Handoyo Luisa Diana , Nuryani Hadistia Siti , Dewi Rishe Purnama 
Published: September 2024

Computational Thinking (CT) skills are crucial for students in various academic disciplines. This study investigated the relationship between CT perspective, digital competence, and unplugged CT skills among college students. The study aimed to assess the influence of the CT perspective and digital competence onunplugged CT skills across different academic departments and programs. It also explored potential moderating effect of gender, grade level, study program, and GPA. The unplugged CT refers to practicing computational thinking skills without the use of Scratch applications. A cross-sectional survey design with a random sampling method was employed. Data was collected from 500 college students enrolled in bachelor’s degree programs (science and non-science) at seven universities in Indonesia, from December 2023 to April 2024. The CT skills was collected through 25-item-multiple-choice questions test. CT perspective and digital competence were measured using separate 15-item and 20-item questionnares, respectively, all administered on a 5-point Likert scale that was distributed via Google Form. A structural model with a partial least squares approach was used tp analyze the relationship between the variables. The results indicated that there was a positive relationship between CT perspectives, digital competence, and CT skills. There were significant differences in CT skills based on study program, grade, and GPAs, but not gender. Students in science programs, upper grades, and with higher GPAs demonstrated higher CT skills. This study highlights the importance of fostering CT perspective and digital competence to enhance unplugged CT skills in various academic contexts.
Een verkenning van civiele aansprakelijkheden onder de CSDDD
Authors: Baks M.A.B. , Pennink S.T. 
Published: September 2024

Een verkenning van civiele aansprakelijkheden onder de CSDDD. Een nieuw duurzaamheidsnormenkader in het Nederlandse (ondernemings)recht
Dit artikel onderzoekt mogelijke implicaties van de Corporate Sustainability Due Diligence Directive (CSDDD) voor vennootschappen. Het onderzoek benadrukt de uitdagingen van het aantonen van schendingen van zorgvuldigheidsverplichtingen, de rol van aansprakelijkheidsrecht bij het stimuleren van duurzaamheid en de toenemende aansprakelijkheidsrisico’s volgend uit duurzaamheidsnormering. De bevindingen wijzen op de noodzaak van het implementeren van een effectief due diligence-beleid en transparantie in duurzaamheidsverslaggeving, en op de risico’s van greenwashing in dit kader. De relevantie van dit onderzoek ligt in het benadrukken van de verantwoordelijkheid en plichten van vennootschappen volgend uit de CSDDD om zorgvuldig om te gaan met ESG-thema’s.
Analysis of the Level of Compliance with the Use of Personal Protective Equipment at PT XX Industrial and Construction Development
Authors: Nurfaizah Hasibuan  , Susilawati  Susilawati  
Published: September 2024

The industrial and construction development sector is a sector that really needs workers in the field, therefore with the work in the field, PT must always be vigilant under any circumstances to keep workers from work accidents. By using personal protective equipment to workers. The government has considered the issue of protection for labor, namely through Law No. 1 of 1970 concerning Labor Safety Work safety equipment is equipment that can protect workers from workplace hazards. Compliance with the use of personal protective equipment in PT XX Industrial and Construction Development has been very good. This research uses qualitative research methods. This research was conducted by interviewing workers of pt. XX Industrial and Construction Development. The focus of this study is on the analysis of the level of compliance with the use of personal protective equipment. The population taken was 4 informants, namely 3 workers and 1 safety man. Data taken includes interviews, observations, documentation and data recording. The knowledge of workers in PT XX Industrial and Construction Development is very good, compliance with the use of worker personal protective equipment is also quite good, the personal protective equipment facilities provided by PT are very complete, and the supervision provided by PT is also very routine and has sanctions for those who are caught not wearing PPE in the form of reprimands.
Hubungan Kebiasaan Sarapan Dan Status Gizi Dengan Prestasi Belajar Siswa SDN 345 Kaduaja Benteng Deata Kecamatan Gandang Batu Sillanan, Kabupaten Tana Toraja
Authors: Hayuti Windha Pagiu  , Nofita Tudang Rombeallo  , Fera Dwiyanti  , Nurul Zahira A.N  
Published: September 2024

Introduction: Children's growth and development and learning achievements require adequate nutritional intake by eating breakfast or what is usually called breakfast. Research objective: To determine the relationship between breakfast habits and nutritional status with student learning achievement at SDN 345 ​​Kaduaja, Benteng Deata, Gandang Batu Sillanan District, Tana Toraja Regency. Research method: This research method is descriptive correlational with a cross sectional approach, the sample size is 37 respondents. represents the population. This sampling technique is Proportional Stratified Random Sampling. Data was collected using a questionnaire and tested statistically. Research results: From the results of this research, the majority of respondents were female, 21 students (56.8%), the majority of respondents were 10 years old, 12 students (32.4%). The majority of respondents with good breakfast habits were 19 students (51.4%), the majority of respondents with good nutritional status were 19 students (51.4%) and the majority of respondents with good performance were 25 students (67.6%). The results of the Fisher's exact test statistical test showed that there was no relationship between breakfast habits and learning achievement with a p-value = 0.528 and it was found that there was a relationship between nutritional status and learning achievement with a p-value = 0.033. Conclusion: Based on the research results, it was concluded that there was no relationship breakfast habits and learning achievement. There is a relationship between nutritional status and learning achievement of students at SDN 345 ​​Kaduaja, Deata Deata Castle, Gandang Batu Sillanan subdistrict, Tana Toraja Regency. It is recommended that students meet their nutritional needs by eating healthy and balanced foods.
Profil Risiko Penyakit Jantung Koroner (PJK) pada Wanita Premenopause menggunakan Rasio Profil Lipid
Authors: Mutmainnah Abbas  , Olin Toyi  , Julia F.N  , Rosdiana Mus  
Published: September 2024

Premenopause is a transitional period between the reproductive period and the elderly which is physiological and occurs around age of 45-55 years. Conditions premenopause phase are caused by hormone changes, decreased levels of hormone estrogen. Hormone estrogen functions to regulate balance of body fat and maintain lipolysis in fat tissue and can also prevent in blood by increasing HDL cholesterol levels and reducing triglyceride levels. Atherogenic Index (IA) is a new marker to measure level of atherogenicity directly related to the risk of atherosclerosis calculated from the Log ratio (TG/HDL-c). This research aims to determine the risk profile of Coronary Heart Disease (CHD) in premenopausal women using lipid profile ratios. This study used an analytical method with a cross sectional approach. From 40 subjects who met research criteria, atherogenic index result in low risk category were 6 (15%) people, medium risk 21 (52.5%) people, and high risk 13 (32.5%) people. Based on the research it can be concluded the atherogenic index in premenopause women is 0.27 which the high risk.
Resilience Terhadap Anxiety Lansia Dengan Diabetes Mellitus
Authors: Urafidah Sifa , Eppy Setiyowati  , Ananda Yulistiya Kartini  , Sitti Lathifatul Isniah  , Riska Puspita Rahmawati  , Cindy Fareza  , Lailiyatul Fitri  
Published: September 2024

Seiring bertambahnya usia seseorang, kondisi fisiknya akan memburuk. Kecemasan dapat mengakibatkan perubahan pada kondisi fisik dan psikis. Tujuan Penelitiaan ini bertujuan menganalisis suatu hubungan antara resilience terhadap anxiety pada lansia dengan diabetes mellitus. Metode penelitian menerapkan desain cross sectional. Populasi penelitian ialah lansia di Desa Klurak, Candi, Sidoarjo. Dengan menggunakan metode total sampling, jumlah sampel sebesar 33 responden. Instrumen yang digunakan adalah angket Connor and Davidson Resilience Scale (CD-RISC) dengan 5 indikator untuk mengukur resilience dan kuesioner Hamilton Anxiety Rating Scale (HARS) dengan 14 indikator penilaian untuk mengukur kecemasan. Hasil penelitian uji statistik p-value 0,018 dengan menggunakan uji Spearman, artinya terdapat hubungan signifikan antara resilience terhadap anxiety pada lansia dengan diabetes mellitus. Kesimpulan, semakin baik resilience yang dimiliki oleh lansia dengan diabetes mellitus maka kecemasan akan semakin berkurang, begitu pula sebaliknya. Saran yang diharapkan kepada peneliti selanjutnya yaitu dapat melakukan penelitian yang lebih intensif pada lansia dengan jumlah sampel yang lebih besar, yang akan memperoleh hasil lebih signifikan dan dapat menjadi acuan teori dimasa mendatang
HUBUNGAN PENGGUNAAN GADGET DENGAN KUALITAS TIDUR PADA ANAK USIA REMAJA DI SMA NEGERI 1 TILAMUTA
Authors: Firmawati Firmawati  , Andi Akifa Sudirman  , Maria Rinny Lilir  
Published: September 2024

Gadget merupakan sebuah alat elektronik yang memilki fungsi khusus dengan berbagai teknologi sehingga membuat hidup manusia menjadi lebih praktis. Penggunaan gadget dapat menimbulkan dampak negatif pada anak antara lain menjadi pribadi yang tertutup, kesehatan terganggu, gangguan tidur, suka menyendiri, dan ancaman ciberbullying. Kualitas tidur adalah ukuran dimana seseorang itu dapat kemudahan dalam memulai tidur dan mempertahankan tidur. Anak remaja merupakan masa peralihan dari kanak-kanak menjadi dewasa. Tujuan dari peneIitian ini untuk mengetahui Hubungan Penggunaan Gadget Dengan Kualitas Tidur Pada Anak Remaja di SMA Negeri 1 Tilamuta. Desain peneIitian ini menggunakan metode Deskriptif Analitik dengan rancangan cross sectional. Teknik pengambilan sampel menggunakan proportionate stratisfied random sampling dengan jumlah sampel 91 orang. Tekanik analisis yaitu dengan uji Chi Square. Penelitian ini dilakukan dengan membagikan kuesioner. HasiI peneIitian dengan analisa data menggunakan uji chi square didapatkan nilai significancy 0.001. Berdasarkan nilai tersebut karena nilai p < 0.05 dapat diambil kesimpulan bahwa penggunaan gadget memiliki hubungan terhadap kualitas tidur pada anak usia remaja. di SMA Negeri 1 Tilamuta.
PENGARUH TERAPI MASSAGE EFFLUERAGE TERHADAP NYERI KALA I PADA IBU INPARTU DI RUANGAN PONEK RSUD TANI DAN NELAYAN KABUPATEN BOALEMO
Authors: Rizky Hamidah Assagaf  , Harismayanti Harismayanti  , Ani Retni  
Published: September 2024

Nyeri pada ibu bersalin dapat menyebabkan meningkatnya kadar katekolamin atau hormon sterss. Peningkatan kadar ketekolamin atau hormon sterss dapat mengurangi kemampuan tubuh menahan rasa nyeri.Tujuan dari penelitian ini untuk mengetahui pengaruh terapi massage effluerage terhadap nyeri kala I pada ibu inpartu. Desain penelitian pre eksperimental dengan penelitian one group pre-post test. Populasi dalam penelitian ini ibu bersalin secara normal di ruangan ponek bulan agustus-oktober berjumlah 56 ibu. Sampel berjumlah 36 ibu dengan menggunakan rumus slovin. Instrument yang digunakan yaitu lembar observasi dan menggunakan uji statistik sampel paired T-test. Hasil yang diperoleh nyeri sebelum perlakuan sebanyak 23 responden merasakan nyeri sedang dan 13 responden merasakan nyeri berat, setelah perlakuan 19 responden merasakan nyeri ringan, 15 responden merasakan nyeri sedang dan 2 responden merasakan nyeri berat. Kesimpulan terdapat pengaruh p=0.000 (<0.05) terapi massage effleurage terhadap nyeri kala I pada ibu inpartu diruangan ponek.
KEPATUHAN IBU HAMIL DALAM PEMERIKSAAN ANTENATAL CARE (ANC) 10T DIPUSKESMAS ASPARAGA KAB. GORONTALO
Authors: Astin Maadi  , Harismayanti Harismayanti  , Ani Retni  
Published: September 2024

Pemeriksaan ANC merupakan kegiatan yang sangat penting dalam mengidentifikasi kesejahteraan ibu dan janin. Penelitian ini bertujuan untuk mengetahui Kepatuhan ibu hamil dalam pemeriksaan antenatal care (ANC) 10T. Desain penelitian ini Deskriptif Kuantitatif. Teknik pengambilan sampel menggunakan teknik purposive sampling. Hasil yang di peroleh adalah mayoritas karakteristik responden berdasarkan usia yaitu 17-25 Tahun, mayoritas karakteristik responden berdasarkan pendidikan yaitu SMP, mayaoritas pekerjaan tertinggi yaitu IRT, mayoritas karakteristik Usia Kehamilan tertinggi yaitu Trimester II, mayoritas karakteristik Kepatuhan ibu hamil berdasarkan kunjungan ANC tertinggi dan Berdasarkan hasil penelitian yang dilakukan di Puskesmas Asparaga Kabupaten Gorontalo di dapatkan hasil 24 ibu hamil patuh kunjungan Antenatal Care (ANC) dengan tidak berkualitas (10T) dan di dapatkan hasil 21 ibu hamil dengan tidak patuh kunjungan Antenatal Care (ANC). Hasil penelitian ini diharapkan dapat meningkatkan pelayanan Antenatal Care (ANC) dan mampu memberikan pelayanan Antenatal Care (ANC) berkualitas. Penelitian ini dapat dijadikan sebagai dasar untuk penelitian selanjutnya yang akan bermanfaat bagi kita semua, khususnya dalam pemilihan variabel penelitian yaitu pekerjaan dan dukungan suami.
A imprensa na formação da gramática dos direitos humanos no Brasil: uma estratégia educativa
Authors: Gomes Ana Luisa Zaniboni , Quiroga Aldo Patricio Flores 
Published: September 2024

Discutimos neste artigo estratégias adotadas por jornalistas brasileiros para pautar e produzir reportagens sobre direitos humanos na imprensa nacional. Para esta análise, recorremos a registros de mais de quatro décadas de um dos principais e mais antigos concursos de jornalismo no Brasil – o Prêmio Jornalístico Vladimir Herzog de Anistia e Direitos Humanos (PVH) – e a relatos de profissionais premiados na última década. Tais relatos foram selecionados por critérios de visibilidade jornalística e categorizados a partir de temas como a) aspectos garantidores de publicação; b) envolvimento emocional com temas e fontes; c) linguagem e recursos estéticos para efeito de sentidos, d) temas recorrentes e e) importância da troca de experiências. Partimos da hipótese de que a compreensão desses mecanismos poderia contribuir tanto na ampliação desse tipo de cobertura nos mais variados veículos de mídia do país quanto no estudo de métodos de trabalho dos profissionais, beneficiando o público leitor, estudantes e pesquisadores da área por demonstrar e estimular a importânca da imprensa na gramática dos direitos humanos, na formação da cidadania e na defesa dos valores democráticos. O artigo conclui que, ao criar o espaço público para revelar os bastidores da produção das reportagens premiadas, o PVH introduz uma relação educativa entre discurso jornalístico, público leitor e os próprios profissionais do jornalismo. Tal recurso explicita e contextualiza as condições reais de produção de uma peça jornalística tanto a quem produz quanto para quem lê e estuda jornalismo.
Remote Control and Monitoring System for rural Pump stations using PLC
Authors: Abdulqader Rafeeq Wadhah , TH.H. Thabet Hassaan , Khaire Hussain Mohammed 
Published: September 2024

Several water systems are mechanized to minimize human labor, optimize water utilization, and mitigate water wastage. The researchers suggested implementing remote administration and control for an automated water system. On a remote agricultural property, a pump will utilize a well to replenish a water tank with water. Because of the expensive nature of wired control, it is necessary to activate and deactivate this pump using wireless means in accordance with the water tank's filling level. The system's operator needs have constant access to a cell phone in order to monitor the water level in the tank. In order to accomplish the aforementioned objectives, this article utilizes a LOGO!® Programmable Logic Controller (PLC) and a LOGO!® Communication Module Radio (CMR) manufactured by SIEMENS. SIEMENS utilizes SoftComfort V8.3 as the software for programming and controlling the system.
Le diagnostic médical comme fiction religieuse
Authors: Krause Pamela 
Published: September 2024

L’article rend sensible la critique coctélienne du partage entre le sain et le pathologique à partir de la lecture de son journal intime, intitulé Opium, Journal d’une désintoxication. Rédigé en pleine cure de désintoxication, le journal remet en question la nosologie de l’institution médicale et en refuse les préceptes quasi « religieux ». L’institution médicale est accusée d’assujettir ses patients en les amenant à se constituer comme une subjectivité unitaire, transparente et confessante – sommés d’incorporer et d’incarner les étapes d’un récit téléologique et salvateur. Le parti pris du journal intime remet en cause le « récit » médico-religieux de l’addiction puisqu’échappant à toute totalisation rétrospective, révélant la complexité du vécu en souffrance. Le journal réussit à mettre en lumière l’aveuglement du corps médical face à la fiction inhérente au diagnostic et à la potentialité curative de la littérature.
Images de l’entre-deux : l’Irlande du Nord dans les films Divorcing Jack et ’71
Authors: Bazin Cécile 
Published: September 2024

Le cinéma, à travers sa construction discursive, sa voix indépendante et sa portée populaire, offre un véhicule unique pour aborder la violence politique en Irlande du Nord liée à la division sectaire. Les films sur ce conflit politique, assez répandus depuis ces trois dernières décennies, ont reflété les changements en Irlande du Nord et ont donc participé à l'évolution de la société. Cet article, qui traite de deux films sur le début et la fin des Troubles - Divorcing Jack (1998) de David Caffrey et ’71 (2014) de Yann Demange - observe la lutte incertaine du « héros » qui, pour une raison ou une autre, se trouve dans une zone dangereuse « entre deux » factions. Notre intention ici est de nous concentrer sur ces deux films, à la croisée de genres différents, qui dépeignent le sort des individus qui n'appartiennent à aucune communauté. L'article aborde les questions d’un espace entre-deux, une notion qui bouscule les stéréotypes et les représentations de l’Irlande du Nord.
Un tombeau en musique : souvenir et rituel de deuil dans la fiction britannique et irlandaise contemporaine
Authors: Lecomte Héloïse 
Published: September 2024

Le mythe d’Orphée offre un exemple paradigmatique des liens qui unissent les pouvoirs incantatoires de la musique et le désir (aporétique ?) de ranimer les ombres des morts dans le récit de deuil. Dans la lignée de ce mythe, plusieurs ouvrages de fiction britannique et irlandaise contemporaine comportent des scènes musicales qui semblent œuvrer à la fois à préserver le souvenir des défunts et à constituer un rituel funéraire pour accompagner le processus de deuil. La fin de la nouvelle « The Dead » dans Dubliners (1914) de James Joyce met en scène l’écoute d’une chanson qui mène à une profonde introspection. Dans Artful (2012), Ali Smith dissémine le texte d’une ballade funèbre pour rythmer le retour du fantôme mais aussi des souvenirs du·de la défunt·e, tout comme la musique d’Orphée lui restitue temporairement son Eurydice. Dans The Child in Time (1987) et The Gathering (2007), Ian McEwan et Anne Enright soulignent la valeur relationnelle de la performance musicale. L’élégie visant avant tout à « émouvoir » et à « se souvenir » (Maulpoix De l’élégie 2018, 65), deux caractéristiques qu’elle partage avec la musique, nous chercherons à explorer dans cet article la contribution ou non des scènes musicales au geste élégiaque et à la commémoration (ou mémoire partagée) des défunt·e·s.Dans ces ouvrages, ce n’est pas seulement la pensée de la musique, mais plutôt la performance musicale concrète qui fait émerger la prosopopée, la voix des défunts. Alors que le temps du souvenir envahit la narration, la limite entre vivants et morts s’en trouve brouillée. Cet article se propose d’étudier comment l’irruption de la musique au sein du récit de la mémoire, en constituant un rituel de deuil, peut transformer le roman en un tombeau, au sens musical et monumental du terme.