bluuebunny/crossref_metadata_2025_split huggingface dataset:
A provably secure RFID authentication protocol based on elliptic curve signature with message recovery suitable for m‐Health environments
Authors: Benssalah Mustapha , Djeddou Mustapha , Drouiche Karim 
Published: March 2017

AbstractRadio frequency identification (RFID) is a promising wireless emerging technology for automatic objects identification. This technology is widely deployed in numerous applications and is becoming popular in health‐care environments. Many health‐care services, such as patient monitoring, drug administration systems, and telecare medicine information systems, are automated and powered by the RFID technology. This rigorous redeployment is done to improve the quality and effectiveness of patient care and many other aspects. Henceforth, the confidentiality and privacy of the personal electronic health‐care information become progressively challenging. In this context, with more and more significant and rigorous security requirements, elliptic curve cryptography has been intensively suggested to design efficient RFID authentication protocols. In this paper, we propose a secure mobile RFID authentication protocol to increase the safety of the patient data records and the work efficiency of medical staff. Our proposal uses the elliptic curve signature with message recovery. To the best of our knowledge, it is the first time the elliptic curve signature with message recovery signature is introduced for RFID medical applications. The proposed protocol is validated using field programmable gate arrays) technology. In addition, via formal and informal security analysis, we show that our proposal could solve security weaknesses of some previously proposed protocols, provide mobility, privacy, scalability, and can be adapted for multiserver environment.
Emergence of a hierarchical brain during infancy reflected by stepwise functional connectivity
Authors: Pendl Suzanne L. , Salzwedel Andrew P. , Goldman Barbara D. , Barrett Lisa F. , Lin Weili , Gilmore John H. , Gao Wei 
Published: March 2017

AbstractThe hierarchical nature of the brain's functional organization has long been recognized, but when and how this architecture emerges during development remains largely unknown. Here the development of the brain's hierarchical organization was characterized using a modified stepwise functional connectivity approach based on resting‐state fMRI in a fully longitudinal sample of infants (N = 28, with scans after birth, and at 1 and 2 years) and adults. Results obtained by placing seeds in early sensory cortices revealed novel hierarchical patterns of adult brain organization ultimately converging in limbic, paralimbic, basal ganglia, and frontoparietal brain regions. These findings are remarkably consistent with predictive coding accounts of neural processing that place these regions at the top of predictive coding hierarchies. Infants gradually developed toward this architecture in a region‐ and step‐dependent manner, and displayed many of the same regions as adults in top hierarchical positions, starting from 1 year of age. The findings further revealed patterns of inter‐sensory connectivity likely reflecting the emergence and development of multisensory processing strategies during infancy, the strengths of which were correlated with early cognitive development scores. Hum Brain Mapp 38:2666–2682, 2017. © 2017 Wiley Periodicals, Inc.
Improving patient health engagement with mobile texting: A pilot study in the head and neck postoperative setting
Authors: Sosa Alan , Heineman Nathan , Thomas Kimberly , Tang Kai , Feinstein Marie , Martin Michelle Y. , Sumer Baran , Schwartz David L. 
Published: March 2017

ABSTRACTBackgroundCell phone ownership is nearly universal. Messaging is one of its most widely used features. Texting‐based interventions may improve patient engagement in the postoperative setting, but remain understudied.MethodsPatients were recruited before discharge from the hospital and received automated daily texts for 1 week providing information about expected recovery. Patients were encouraged to text questions to providers, which were triaged for intervention. Web‐based surveys solicited patient feedback about the platform.ResultsThirty‐two patients were approached, and 23 patients (72%) were enrolled in the study. All study patients texted their providers, although frequency (median, 7 texts; range, 2–44 texts) varied. Unmarried patients and those facing surgical complications used the platform more frequently. Mean patient satisfaction with the platform was high (mean, 3.8 on a 4‐point Likert scale).ConclusionText messaging seems feasible in the acute postoperative setting and potentially improves engagement of patients with head and neck cancer. Further study is warranted to confirm scalability and impact. © 2017 Wiley Periodicals, Inc. Head Neck 39: 988–995, 2017
Longitudinal monitoring of the head and neck lymphatics in response to surgery and radiation
Authors: Rasmussen John C. , Tan I‐Chih , Naqvi Syed , Aldrich Melissa B. , Maus Erik A. , Blanco Angel I. , Karni Ron J. , Sevick–Muraca Eva M. 
Published: March 2017

ABSTRACTBackgroundThe lymphatic vasculature provides a route for cancer metastases, and its dysfunction after cancer treatment can result in lymphedema. However, changes in the lymphatics before, during, and after surgery and radiation remain unclear.MethodsNear‐infrared fluorescence lymphatic imaging was performed before and after lymph node dissection and fractionated radiotherapy to assess changes in external lymphatic function.ResultsPatients who underwent both lymph node dissection and radiotherapy developed lymphatic dermal backflow on treated sides ranging from days after the start of radiotherapy to weeks after its completion, whereas contralateral regions that were not associated with lymph node dissection but also treated with radiotherapy experienced no such changes in external lymphatic anatomies.ConclusionThe external lymphatics undergo transient changes during and weeks after lymph node dissection and radiotherapy. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1177–1188, 2017
Spatiotemporal estimation of snow depth using point data from snow stakes, digital terrain models, and satellite data
Authors: Collados‐Lara Antonio‐Juan , Pardo‐Igúzquiza Eulogio , Pulido‐Velazquez David 
Published: March 2017

AbstractSnow availability in Alpine catchments plays an important role in water resources management. In this paper, we propose a method for an optimal estimation of snow depth (areal extension and thickness) in Alpine systems from point data and satellite observations by using significant explanatory variables deduced from a digital terrain model. It is intended to be a parsimonious approach that may complement physical‐based methodologies. Different techniques (multiple regression, multicriteria analysis, and kriging) are integrated to address the following issues: We identify the explanatory variables that could be helpful on the basis of a critical review of the scientific literature. We study the relationship between ground observations and explanatory variables using a systematic procedure for a complete multiple regression analysis. Multiple regression models are calibrated combining all suggested model structures and explanatory variables. We also propose an evaluation of the models (using indices to analyze the goodness of fit) and select the best approaches (models and variables) on the basis of multicriteria analysis. Estimation of the snow depth is performed with the selected regression models. The residual estimation is improved by applying kriging in cases with spatial correlation. The final estimate is obtained by combining regression and kriging results, and constraining the snow domain in accordance with satellite data. The method is illustrated using the case study of the Sierra Nevada mountain range (Southern Spain). A cross‐validation experiment has confirmed the efficiency of the proposed procedure. Finally, although it is not the scope of this work, the snow depth is used to asses a first estimation of snow water equivalent resources.
Effect of Applying Sewage Effluent with Subsurface Drip Irrigation on Soil Enzyme Activities during the Maize Growing Season
Authors: Qiu Zhenjie , Li Jiusheng , Zhao Weixia 
Published: March 2017

AbstractSubsurface drip irrigation is an appropriate method when using sewage effluent for crop irrigation, but its resultant heterogeneous distribution of water and nutrients in the soil may affect enzyme activities (EAs). Field experiments were designed, with three lateral depths at 0, 15, and 30 cm beneath the soil surface and three irrigation levels of 70, 100, and 130% of evapotranspiration, to investigate the effects of lateral depth, irrigation level, and water quality on the EAs of alkaline phosphatase, urease, and invertase in soil. Over 2 years, a greater lateral depth noticeably enhanced EAs in deeper soils, while EAs at a shallow lateral depth were higher in topsoil. Compared to lateral depth, the effects of irrigation level on EAs were unstable in both years. The correlations between urease activities and NO3‐N content indicated that the character of urease activities in soil N cycling was initially facilitating N mineralization and was subsequently converted to facilitate N uptake and immobilization during the maize growing seasons. Additionally, the EAs with both sewage effluent and groundwater irrigation at harvest, were generally higher than EAs measured prior to sowing. Furthermore, the sewage effluent irrigation imposed no negative effects on nutrient exchange and ecosystem functions in the soil. Our study recommends subsurface drip irrigation as a promising method for applying sewage effluent. Copyright © 2017 John Wiley & Sons, Ltd.
Prognostic significance of CD133 and ezrin expression in colorectal carcinoma
Authors: Fathi Anan , Mosaad Hala , Hussein Samia , Roshdy Mona , Ismail Eman I. 
Published: March 2017

AbstractDespite the improvement in the diagnostic and the therapeutic modalities, colorectal cancer (CRC) morbidity and mortality remain high in both the developed and the developing countries. So, we are in a need to recognize new efficient diagnostic and prognostic biomarkers of CRC. That may help in providing individualized targeted therapy for this lethal malignancy. In this study, we investigated the expression and the prognostic significance of CD133 and ezrin mRNA and protein by quantitative RT‐PCR and immunohistochemical analysis in primary CRC cases and the surrounding normal colonic mucosa. The correlations between the expression of both markers and clinicopathological parameters were performed. Compared to control, the expression of CD133 and ezrin mRNA and protein in CRC were significantly up‐regulated (P < 0.05). In addition, a strong positive correlation between both markers was found (r = 0.867, P < 0.001). Moreover, elevated levels of both markers were significantly associated with the stage, lymph node involvement, distant metastasis, and recurrence at both mRNA and protein levels (P < 0.05). In conclusion, there is a clinical significance of CD133 and ezrin as potential biomarkers for predicting CRC patients of aggressive behavior and poor prognosis. © 2017 IUBMB Life, 69(5):328–340, 2017
Effects of aging on cadmium concentrations and renal dysfunction in inhabitants in cadmium‐polluted regions in Japan
Authors: Phuc Hoang Duc , Kido Teruhiko , Oanh Nguyen Thi Phuong , Manh Ho Dung , Anh Le Thai , Oyama Yuko , Okamoto Rie , Ichimori Akie , Nogawa Kazuhiro , Suwazono Yasushi , Nakagawa Hideaki 
Published: March 2017

AbstractThe absorption of cadmium (Cd) may lead to Cd‐related diseases such as renal tubular dysfunction and bone disease, and it is known to take around 10–30 years to reduce Cd concentrations to half their original levels. Urinary β2‐microglobulin (β2‐MG), N‐acetyl‐β‐D‐glucosaminidase (NAG), protein, glucose and albumin were used as indicators of renal dysfunction caused by Cd exposure. Our previous study found that urinary Cd concentrations had increased recently and that age was more strongly associated with urinary β2‐MG concentration than recent Cd body burden. Therefore, the purpose of the present study was to investigate the effect of aging on Cd concentrations and renal dysfunction. The Cd, β2‐MG, NAG, protein, glucose and albumin concentrations in the urine of 40 Japanese subjects (20 females and 20 males) environmentally exposed to Cd were collected. They lived in the Kakehashi River basin and were divided into three age categories: 50–69, 70–79 and 80–99 years. Significant differences in urinary Cd and β2‐MG concentrations were found among age groups, with urinary Cd levels tending to increase with age in both sexes. No significant correlations were found between urinary Cd and any indicators of renal dysfunction. The correlation between age, Cd and indicators of renal dysfunction was observed more clearly in females than in males. Age is more strongly correlated with indicators of renal dysfunction than Cd body burden. Copyright © 2017 John Wiley & Sons, Ltd.
The effect of cell debris within biologic scaffolds upon the macrophage response
Authors: Londono Ricardo , Dziki Jenna L. , Haljasmaa Eric , Turner Neill J. , Leifer Cynthia A. , Badylak Stephen F. 
Published: March 2017

AbstractAll biomaterials, including biologic scaffolds composed of extracellular matrix (ECM), elicit a host immune response when implanted. The type and intensity of this response depends in part upon the thoroughness of decellularization and removal of cell debris from the source tissue. Proinflammatory responses have been associated with negative downstream remodeling events including scar tissue formation, encapsulation, and seroma formation. The relative effects of specific cellular components upon the inflammatory response are not known. The objective of the present study was to determine the effect of different cell remnants that may be present in ECM scaffold materials upon the host innate immune response, both in vitro and in vivo. Collagen scaffolds were supplemented with one of three different concentrations of DNA, mitochondria, or cell membranes. Murine macrophages were exposed to the various supplemented scaffolds and the effect upon macrophage phenotype was evaluated. In vivo studies were performed using an abdominal wall defect model in the rat to evaluate the effect of the scaffolds upon the macrophage response. Murine macrophages exposed in vitro to scaffolds supplemented with DNA, mitochondria, and cell membranes showed increased expression of proinflammatory M1 marker iNOS and no expression of the proremodeling M2 marker Fizz1 regardless of supplementation concentration. A dose‐dependent response was observed in the rat model for collagen scaffolds supplemented with cell remnants. DNA, mitochondria, and cell membrane remnants in collagen scaffolds promote a proinflammatory M1 macrophage phenotype in vivo and in vitro. These results reinforce the importance of a thorough decellularization process for ECM biologic scaffold materials. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2109–2118, 2017.
The Opportunity of Precision Medicine for Breast Cancer With Context‐Sensitive Tumor Suppressor Maspin
Authors: Bernardo Margarida M. , Dzinic Sijana H. , Matta Maria J. , Dean Ivory , Saker Lina , Sheng Shijie 
Published: March 2017

ABSTRACTTo improve the precision of molecular diagnosis and to develop and guide targeted therapies of breast cancer, it is essential to determine the mechanisms that underlie the specific tumor phenotypes. To this end, the application of a snapshot of gene expression profile for breast cancer diagnosis and prognosis is fundamentally challenged since the tissue‐based data are derived from heterogonous cell types and are not likely to reflect the dynamics of context‐dependent tumor progression and drug sensitivity. The intricate network of epithelial differentiation program can be concertedly controlled by tumor suppressor maspin, a homologue of clade B serine protease inhibitors (serpin), through its multifaceted molecular interactions in multiple subcellular localizations. Unlike most other serpins that are expressed in multiple cell types, maspin is epithelial specific and has distinct roles in luminal and myoepithelial cells. Endogenously expressed maspin has been found in the nucleus and cytoplasm, and detected on the surface of cell membrane. It is also secreted free and as an exosomal cargo protein. Research in the field has led to the identification of the maspin targets and maspin‐associated molecules, as well as the structural determinants of its suppressive functions. The current review discusses the possibility for maspin to serve as a cell type‐specific and context‐sensitive marker to improve the precision of breast cancer diagnosis and prognosis. These advancements further suggest a new window of opportunity for designing novel maspin‐based chemotherapeutic agents with improved anti‐cancer potency. J. Cell. Biochem. 118: 1639–1647, 2017. © 2017 Wiley Periodicals, Inc.
Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1‐Dependent Mechanism During Hepatocyte Lipotoxicity
Authors: Tomita Kyoko , Kabashima Ayano , Freeman Brittany L. , Bronk Steven F. , Hirsova Petra , Ibrahim Samar H. 
Published: March 2017

ABSTRACTSaturated fatty acids (SFA) and their toxic metabolites contribute to hepatocyte lipotoxicity in nonalcoholic steatohepatitis (NASH). We previously reported that hepatocytes, under lipotoxic stress, express the potent macrophage chemotactic ligand C‐X‐C motif chemokine 10 (CXCL10), and release CXCL10‐enriched extracellular vesicles (EV) by a mixed lineage kinase (MLK) 3‐dependent mechanism. In the current study, we sought to examine the signaling pathway responsible for CXCL10 induction during hepatocyte lipotoxicity. Here, we demonstrate a role for signal transducer and activator of transcription (STAT) 1 in regulating CXCL10 expression. Huh7 and HepG2 cells were treated with lysophosphatidylcholine (LPC), the toxic metabolite of the SFA palmitate. In LPC‐treated hepatocytes, CXCL10 induction is mediated by a mitogen activated protein kinase (MAPK) signaling cascade consisting of a relay kinase module of MLK3, MKK3/6, and p38. P38 in turn induces STAT1 Ser727 phosphorylation and CXCL10 upregulation in hepatocytes, which is reduced by genetic or pharmacological inhibition of this MAPK signaling cascade. The binding and activity of STAT1 at the CXCL10 gene promoter were identified by chromatin immunoprecipitation and luciferase gene expression assays. Promoter activation was attenuated by MLK3/STAT1 inhibition or by deletion of the consensus STAT1 binding sites within the CXCL10 promoter. In lipotoxic hepatocytes, MLK3 activates a MAPK signaling cascade, resulting in the activating phosphorylation of STAT1, and CXCL10 transcriptional upregulation. Hence, this kinase relay module and/or STAT1 inhibition may serve as a therapeutic target to reduce CXCL10 release, thereby attenuating NASH pathogenesis. J. Cell. Biochem. 118: 3249–3259, 2017. © 2017 Wiley Periodicals, Inc.
Randomized Controlled Trial of Inner Resources Meditation for Family Dementia Caregivers
Authors: Waelde Lynn C. , Meyer Hilary , Thompson Jason M. , Thompson Larry , Gallagher‐Thompson Dolores 
Published: March 2017

ObjectiveThis randomized controlled trial examined the comparative effectiveness of 2 interventions for improving diurnal cortisol slope and life satisfaction and reducing stress symptoms among older female dementia family caregivers.MethodThirty‐one family dementia caregivers were randomized to 8 weeks of Inner Resources for Stress mindfulness meditation and mantra training (IR) or psychoeducation and telephone support (PTS).ResultsIntention‐to‐treat analyses revealed statistically significant pre‐post improvements in diurnal cortisol slope and overall life satisfaction, but not depression or self‐efficacy, in the IR relative to the PTS group. Adherence to between‐session meditation practice was significantly associated with decreases in depression and self‐reported improvements in ability to cope with stress. In addition, IR participants rated the overall benefits of the program more highly than the PTS group.ConclusionThese results indicate that mindfulness meditation and mantra has promise as a feasible and effective caregiver intervention for quality of life and physiological responding to stress.
Initial experience with intra‐fraction motion monitoring using Calypso guided volumetric modulated arc therapy for definitive prostate cancer treatment
Authors: Bell Linda J. , Eade Thomas , Kneebone Andrew , Hruby George , Alfieri Florencia , Bromley Regina , Grimberg Kylie , Barnes Mardi , Booth Jeremy T. 
Published: March 2017

AbstractIntroductionAccurate delivery of radiation while reducing dose to organs at risk is essential in prostate treatment. The Calypso motion management system detects and corrects both inter‐ and intra‐fraction motion which offers potential benefits over standard alignment to fiducial markers. The aims of this study were to implement Calypso with Dynamic Edge™ gating and to assess both the motion seen, and interventions required.MethodsAn implementation group was formed which assessed changes needed to standard workflows. Three patients had Calypso beacons inserted into their prostate. All patients were treated using volumetric modulated arc therapy to a dose of 80 Gy in 40 fractions. Standard inter‐fraction motion correction using either kilovoltage (kV) orthogonal paired imaging or cone beam computed tomography (CBCT) image‐guided radiotherapy techniques, were used along with the Calypso system to compare accuracy. A gating threshold of >0.5 cm was used during treatment. Workflow variations along with inter‐ and intra‐fraction motion and interventions required were assessed.ResultsA total of 116 fractions were treated using Calypso with Dynamic Edge™ gating. There was a strong concordance between aligning beacons using kV orthogonal imaging or CBCT and Calypso (mean variation ≤0.06 cm). The mean intra‐fraction motion detected was ≤0.2 cm in all directions with the largest motion recorded being 2.2 cm in the left direction while the treatment beam was off. Prostate rotation was largest in the pitch direction and 28 fractions exceeded the 10° tolerance. A total of 78 couch shift corrections of ≥0.3 cm were required, usually following standard imaging, and before treatment starting. Three gating events due to intra‐fraction motion occurred during treatment.ConclusionsIntra‐fraction motion monitoring with Calypso was successfully implemented. Greatest movement was seen between time of standard imaging and treatment starting with more than half the treatments requiring a ≥0.3 cm adjustment. This would not have been detected without intra‐fraction monitoring.