bluuebunny/crossref_metadata_2025_split huggingface dataset:
Daylight strategies for architectural studio facilities: the literature review
Authors: Anas Bin Othman Muhammad , Ahmad Nur Azfahani , Md Ajis Azizah 
Published: June 2017

Abstract
The implementation of daylighting strategies in buildings is a common aspect in architecture. However, due to the availability of inexpensive electricity, natural lighting strategies became insignificant, and been overlooked by designers. With the current concern over rapid increment on electricity cost, many designers now try to revitalized daylighting strategies in buildings. This includes educational buildings. In Malaysian cases, it is a norm that universities; especially during lecture and studio sessions, used artificial lighting throughout the day. Definitely, this is not parallel with the “green” aim made by the Government in the Malaysian Plan. Therefore, this paper aims to explore the impact of daylight strategies for educational studios in universities, by maximising the penetration of natural daylight into the space towards creating a more green-conducive studio. The paper review literature about the types, criteria and benefits of daylight strategies. This paper also presented a pilot study that has been performed in one university in Perak, Malaysia, by selecting architectural studios as the main subject.
Dependence of the separative power of an optimised Iguassu gas centrifuge on the velocity of rotor
Authors: Bogovalov Sergey Vladimirovich , Borman Vladimir Dmitrievich , Borisevich Valentin Dmitrievich , Tronin Vladimir Nikolaevich , Tronin Ivan Vladimirovich 
Published: June 2017

Purpose
The purpose of this work is to determine dependence of the separative power of the Iguassu gas centrifuge (GC) on the velocity of the rotor.

Design/methodology/approach
The dependence is determined by means of computer simulation of the gas flow in the GC and numerical solution of the diffusion equation for the light component of the binary mixture of uranium isotopes. 2D axisymmetric model with the sources/sinks of the mass, angular momentum and energy reproducing the scoops was explored for the computer simulation. Parameters of the model correspond to the parameters of the so-called Iguassu centrifuge. The separative power has been optimised in relation to the pressure of the gas, temperature of the gas, the temperature drop along the rotor, power of the source of angular momentum and energy, feed flow and geometry of the lower baffle.

Findings
In the result, the optimised separative power depends only on the velocity, length and diameter of the rotor. The dependence on the velocity is described by the power law function with the power law index 2.6 which demonstrate stronger dependence on the velocity than it follows from experimental data. However, the separative power obtained with limitation on the pressure growth with the velocity depends on the velocity on the power ∼ 2 which well agree with the experiments.

Originality/value
For the first time, the optimised separative power of the GCs have been calculated via numerical simulation of the gas flow and diffusion of the binary mixture of isotope.
Unsteady MHD rear stagnation-point flow over off-centred deformable surfaces
Authors: Turkyilmazoglu Mustafa , Naganthran Kohilavani , Pop Ioan 
Published: June 2017

Purpose
The purpose of this paper is to present both an analytical and a numerical analysis of the unsteady magnetohydrodynamic (MHD) rear stagnation-point flow over off-centred deformable surfaces.

Design/methodology/approach
The numerical MATLAB solver bvp4c suitable for routine boundary value problem is used for the set of ordinary differential equations reduced from the governing partial differential equations.

Findings
Multiple solutions are found for particular eigenvalues. The physical solution is computed by the help of a linear stability analysis. The authors have succeeded in discovering the second solutions, and it is suggested that these solutions are unstable and not physically realisable in practice. The current findings add to a growing body of literature on MHD stagnation-point flow problems. It is also found that the governing parameters have different effects on the flow characteristics.

Practical implications
Even though problems of steady MHD flows have been extensively studied for stagnation-point flows, limited findings can be found on the unsteady MHD rear stagnation-point flow over off-centred deformable surfaces.

Originality/value
The originality of this work is the application of a magnetic field on a time-dependent MHD rear stagnation-point flow over off-centred deformable surfaces.
Macrophage inhibitory cytokine‐1/growth differentiation factor‐15 as a predictor of colonic neoplasia
Authors: Danta M. , Barber D. A. , Zhang H. P. , Lee‐Ng M. , Baumgart S. W. L. , Tsai V. W. W. , Husaini Y. , Saxena M. , Marquis C. P. , Errington W. , Kerr S. , Breit S. N. , Brown D. A. 
Published: June 2017

SummaryBackgroundSerum macrophage inhibitory cytokine‐1 (MIC‐1/GDF15) concentration has been associated with colonic adenomas and carcinoma.AimsTo determine whether circulating MIC‐1/GDF15 serum concentrations are higher in the presence of adenomas and whether the level decreases after excision.MethodsPatients were recruited prospectively from a single centre and stratified into five groups: no polyps (NP); hyperplastic polyps (HP); sessile serrated ademona (SSA); adenomas (AP); and colorectal carcinoma (CRC). Blood samples were collected immediately before and 4 weeks after colonoscopy. MIC‐1/GDF15 serum levels were quantified using ELISA.ResultsParticipants (n=301) were stratified as: NP; n=116 (52%), HP; n=37 (12%), SSA; n=19 (7%), AP; n=68 (23%); and CRC; n=3 (1%). Patients were excluded from the study due to nondiagnostic pathology (n=9, 3%) and exclusion criteria (n=20, 6%). In the 272 remaining subjects (M=149; F=123), age (P=.005), history of colonic polyps (P=.003) and family history of colonic polyps (P=.002) were associated with presence of adenomas. Baseline median MIC‐1/GDF15 serum levels increased significantly from NP 609 (460‐797) pg/mL, HP 582 (466‐852) pg/mL, SSA 561 (446‐837) pg/mL to AP 723 (602‐1122) pg/mL and CRC 1107 (897‐1107) pg/mL; (P<.001). In the pre‐ and postpolypectomy paired adenoma samples median MIC‐1/GDF15 reduced significantly from 722 (603‐1164) pg/mL to 685 (561‐944) pg/mL (P=.002). A ROC analysis for serum MIC‐1/GDF15 to identify adenomatous polyps indicated an area under the curve of 0.71.ConclusionsOur data suggest that serum MIC‐1/GDF15 has the diagnostic characteristics to increase the detection of colonic neoplasia and improve screening.
Randomised non‐inferiority trial: 1600 mg versus 400 mg tablets of mesalazine for the treatment of mild‐to‐moderate ulcerative colitis
Authors: D'Haens G. R. , Sandborn W. J. , Zou G. , Stitt L. W. , Rutgeerts P. J. , Gilgen D. , Jairath V. , Hindryckx P. , Shackelton L. M. , Vandervoort M. K. , Parker C. E. , Muller C. , Pai R. K. , Levchenko O. , Marakhouski Y. , Horynski M. , Mikhailova E. , Kharchenko N. , Pimanov S. , Feagan B. G. 
Published: June 2017

SummaryBackgroundHigh concentration mesalazine formulations are more convenient than conventional low concentration formulations for the treatment of ulcerative colitis (UC).AimTo compare the efficacy and safety of 1600 mg and 400 mg tablet mesalazine formulations.MethodsPatients with mild‐to‐moderate active UC (Mayo Clinic Score >5; N=817) were randomised to 3.2 g of oral mesalazine, administered as two 1600 mg tablets once, or four 400 mg tablets twice daily. We hypothesised that treatment with the 1600 mg tablet was non‐inferior (within a 10% margin) to the 400 mg tablet for induction of clinical and endoscopic remission at week 8. Open‐label treatment with the 1600 mg tablet continued for 26‐30 weeks based on induction response. Predictors of treatment response were also explored.ResultsAt week 8, remission occurred in 22.4% and 24.6% of patients receiving the 1600 mg and 400 mg tablets, respectively (absolute difference −2.2%, 95% CI: −8.1% to 3.8%, non‐inferiority P=.005). Endoscopic and histopathologic disease activity, leucocyte concentration and age were significantly associated with clinical remission (P=.022, .042, .014 and .023, respectively). At week 38, 43.9% (296/675) of patients who continued treatment with the 1600 mg formulation were in remission, including 70.3% (142/202) of patients who received a reduced dose of mesalazine (1.6 g/d). The overall incidence of serious adverse events was low.ConclusionsInduction therapy with 3.2 mg mesalazine using two 1600 mg tablets once‐daily was statistically and clinically non‐inferior to a twice‐daily regimen using four 400 mg tablets (NCT01903252).
DOES NEAR‐RATIONALITY MATTER IN FIRST‐ORDER APPROXIMATE SOLUTIONS? A PERTURBATION APPROACH
Authors: Hespeler Frank , Sorge Marco M. 
Published: June 2017

ABSTRACTThis paper studies first‐order approximate solutions to near‐rational dynamic equilibrium models. Under near‐rationality, agents' subjective beliefs are distorted away from rational expectations via a change of measure process which fulfills some regularity conditions. In most applications, the beliefs distortion process is also directly observed by (a subset of) the decision‐makers – e.g., ambiguity‐averse households or policy‐makers with a concern for robustness – and therefore included into their optimization problems. We investigate conditions for existence and local uniqueness of solutions under endogenous distortions, as well as the relation with their rational expectations counterparts. We show that linearly perturbed solutions may well be affected by the presence of distorted beliefs, depending on the underlying model economy. In particular, while directly affecting first‐order decision rules, near‐rationality may also induce failure of the certainty equivalence principle. Moreover, the martingale representation of distorted beliefs might prove non‐unique, pointing to a subtle form of equilibrium indeterminacy.
South–South? Culture Talk and Labour Relations at a Chinese‐owned Factory in Hungary
Authors: Nyíri Pál , Xu Xiuli 
Published: June 2017

ABSTRACTIn 2011, a large Hungarian chemical factory was acquired by a Chinese competitor. The resulting encounter between Chinese managers and Hungarian staff — which took place in the context of a harsh retrenchment that has curtailed the powers of organized labour in Hungary — highlights the inadequacy of dichotomies such as North/South, East/West and socialist/capitalist. As with other corporate acquisitions in Europe, Chinese managers expected to ‘learn’ from ‘advanced Western management practices’; instead, they found what they interpreted as a backward, ‘socialist’ work culture in need of modernization. For their part, Hungarian staff feared the imposition of a culturally inappropriate ‘Asian labour discipline’, but have come to see at least some of the changes as part of a necessary modernization. ‘Asian’, ‘European’, ‘Western’ and ‘socialist’ are floating signifiers used by both Chinese and Hungarian staff at the factory in various, often contradictory ways to justify management choices, staff resistance or individual preferences. As a result of their analysis, the authors suggest that discussions about the impact of Chinese investment on labour practices should recognize a wider range of contexts, including the presence of precarious socioeconomic environments within the so‐called ‘advanced economies’.
Single‐incision percutaneous pericardial ICD lead placement in a piglet model
Authors: Clark Bradley C. , Opfermann Justin D. , Davis Tanya D. , Krieger Axel , Berul Charles I. 
Published: June 2017

AbstractIntroductionOur group has demonstrated the feasibility of percutaneous pericardial ICD lead placement in a piglet model utilizing direct visualization from a lateral thoracoscopic approach. Development of a novel delivery tool that incorporates visualization allows for the procedure to be performed with a 1 cm subxiphoid incision.Methods and resultsA 1 cm incision is made in the subxiphoid area and a novel self‐anchoring delivery tool is inserted. A rigid thoracoscope and needle are inserted into two crossed working channels of the tool. After needle visualization, pericardial needle access, followed by sheath access is obtained. A modified side‐biting ICD lead is inserted and fixated to the ventricular epicardial surface. The lead is connected to an ICD generator and lead testing followed by defibrillation threshold testing (DFT) is performed. Single‐incision ICD lead placement was performed in 6 piglets without acute complications. Median time from subxiphoid incision to DFT testing was 64 minutes; median time from thoracoscope insertion to lead fixation was 16.5 minutes (range 9–30). All had adequate ventricular sensing and pacing at implant and underwent successful defibrillation (range 3–5 J). Survival period ranged from 1 to 16 weeks. Two piglets had survival periods of 12 and 16 weeks with mean weight gain of 7 kg; both had successful repeat DFT at 10 J. All survival animals had stable lead impedances and R‐wave amplitudes throughout the survival period.ConclusionPercutaneous pericardial placement of an ICD lead using our novel access tool can be safely performed through a 1 cm incision without complications.
Slow antegrade excitation and delayed retrograde activation through an “inexcitable zone”: A basis for arrhythmia formation in infarcted myocardium ex vivo
Authors: Patterson Eugene , Scherlag Benjamin J. 
Published: June 2017

AbstractIntroductionThe electrophysiologic mechanism for rate‐dependent PVBs associated with double potentials (DPs) was investigated in infarcted canine hearts using bipolar and intracellular microelectrode recordings.Methods and resultsDogs exhibiting rate‐related ventricular ectopic beats (coupling interval, 390 ± 54 milliseconds) during sinus rhythm or atrial pacing were studied 4–5 days (N = 63) or 25 days (N = 16) following anterior descending coronary artery ligation. Sites of DP and rate‐dependent arrhythmia formation were identified in vivo using bipolar recordings for subsequent ex vivo studies. Rate‐dependent conduction delays with increasing duration isoelectric intervals representing very slow conduction were observed at sites of DP formation, frequently provoking both manifest and concealed reentry (non‐stimulated beats) over a narrow range of paced cycle lengths. Both slow antegrade and retrograde activation across an inexcitable gap (reflection) were integral components of extrasystole formation. Retrograde reflection to a region of very slow conduction (mid‐potential) during antegrade activation was routinely observed at 4–5 days (42 of 63 preparations, 67%) and 25 days (22 of 26 preparations, 85%) postcoronary artery ligation. Reflection and premature re‐activation of the proximal site was then observed in 6 of 63 (9%), and 3 of 26 preparations (12%).ConclusionThe present experiments demonstrate DP formation and rate‐dependent constant‐coupled late epicardial premature beats in infarcted dog hearts. Microelectrode recordings at DP sites demonstrating prolonged isoelectric intervals display very slow conduction preceding distal activation and “reentrant” re‐activation of more proximal sites, representing reflection as an arrhythmia mechanism in ischemically injured epicardium during subacute myocardial infarction.
A Personal Social History of a Typology of Intimate Partner Violence
Authors: Johnson Michael P. 
Published: June 2017

AbstractThis article is a personal social narrative of the development of my control‐based typology of intimate partner violence (IPV). The influence of friends and colleagues in all aspects of this process was so central and so pervasive that it just did not make sense to me to make this a story only about myself. After I tell the social story of the development of the first version and then later versions of my thinking about types of IPV, I leave the personal realm and lay out the implications of the typology for the question of the relationship between gender and intimate partner violence. Finally, I briefly tie the gender question to the general issues of inequality that have driven me throughout my career.
Long‐term clinical results of bioresorbable absorb scaffolds using the PSP‐technique in patients with and without diabetes
Authors: Markovic Sinisa , Kugler Christine , Rottbauer Wolfgang , Wöhrle Jochen 
Published: June 2017

ObjectivesWe evaluated clinical results up to 36 months after implantation of Absorb BVS using PSP‐technique and compared the outcome of patients with and without diabetes mellitus.BackgroundAbsorb II demonstrated that interventional treatment of coronary artery disease with bioresorbable vascular scaffolds (BVS) without proper PSP‐technique (pre‐dilation, proper sizing, and post‐dilation) is associated with an increased thrombotic risk, even in simple lesions.MethodsIn this prospective study 319 patients with 420 lesions were enrolled and treated with the Absorb BVS. Pre‐dilation was mandatory and post‐dilation with a high‐pressure balloon was performed in patients with a scaffold length >12 mm. Patients were clinically followed up to 3 years. Primary outcome measure was the device‐oriented endpoint (DoCE) defined as cardiac death, myocardial infarction not clearly related to a non‐target vessel and target lesion revascularization.ResultsDoCE was 5.0%, 7.1%, and 10.0% after 12, 24, and 36 months for the total population. Rate of scaffold thrombosis was 0.5%, 0.8%, and 1.4% after 12, 24, and 36 months. Rate of DoCE was higher in the diabetic subgroup with 9.1%, 12.6%, and 12.9% after 12, 24, and 36 months compared with 4.0% (P = 0.13), 5.6% (P = 0.05), and 9.9% (P = 0.20) in patients without diabetes mellitus.ConclusionsPatients treated with the Absorb BVS using the PSP‐technique show good results up to 3 years with a low rate of scaffold thrombosis. Patients suffering from diabetes mellitus have an increased rate of DoCE compared with non‐diabetic patients.Clinical Trial Registrationclinicaltrials.gov_NCT02162056.
The Vexed Question of Market Stewardship in the Public Sector: Examining Equity and the Social Contract through the Australian National Disability Insurance Scheme
Authors: Carey Gemma , Dickinson Helen , Malbon Eleanor , Reeders Daniel 
Published: June 2017

AbstractPersonalized care and market‐based approaches to public service provision have gained prominence in a range of Organisation for Economic Co‐operation and Development countries. Australia has recently joined this trend, launching a complex and expansive programme of individualized care funding for disability through the National Disability Insurance Scheme. Public sector markets (i.e. where governments either directly fund a market by way of competitive tendering, or through personal budgets) have been embraced by actors at different points of the political spectrum and for a range of reasons, including efficacy and efficiency gains, empowerment of citizens and efforts to cater for diversity. Despite the growing dominance of public sector markets and individualized funding, many questions about the role and responsibility of governments in managing and regulating these markets remain unanswered. In this article we outline different roles governments might assume in the creation and management of public sector markets, based on the types of risks governments are willing to take responsibility for. We argue that to fulfil the social contract between government and citizens, governments need to ensure that markets are properly stewarded and embedded in broader social safety nets. This, we contend, can ensure citizens receive the gains of market models while being protected from market failures or market‐produced inequities.
Somatic Mutations Drive Distinct Imaging Phenotypes in Lung Cancer
Authors: Rios Velazquez Emmanuel , Parmar Chintan , Liu Ying , Coroller Thibaud P. , Cruz Gisele , Stringfield Olya , Ye Zhaoxiang , Makrigiorgos Mike , Fennessy Fiona , Mak Raymond H. , Gillies Robert , Quackenbush John , Aerts Hugo J.W.L. 
Published: June 2017

Abstract
Tumors are characterized by somatic mutations that drive biological processes ultimately reflected in tumor phenotype. With regard to radiographic phenotypes, generally unconnected through present understanding to the presence of specific mutations, artificial intelligence methods can automatically quantify phenotypic characters by using predefined, engineered algorithms or automatic deep-learning methods, a process also known as radiomics. Here we demonstrate how imaging phenotypes can be connected to somatic mutations through an integrated analysis of independent datasets of 763 lung adenocarcinoma patients with somatic mutation testing and engineered CT image analytics. We developed radiomic signatures capable of distinguishing between tumor genotypes in a discovery cohort (n = 353) and verified them in an independent validation cohort (n = 352). All radiomic signatures significantly outperformed conventional radiographic predictors (tumor volume and maximum diameter). We found a radiomic signature related to radiographic heterogeneity that successfully discriminated between EGFR+ and EGFR− cases (AUC = 0.69). Combining this signature with a clinical model of EGFR status (AUC = 0.70) significantly improved prediction accuracy (AUC = 0.75). The highest performing signature was capable of distinguishing between EGFR+ and KRAS+ tumors (AUC = 0.80) and, when combined with a clinical model (AUC = 0.81), substantially improved its performance (AUC = 0.86). A KRAS+/KRAS− radiomic signature also showed significant albeit lower performance (AUC = 0.63) and did not improve the accuracy of a clinical predictor of KRAS status. Our results argue that somatic mutations drive distinct radiographic phenotypes that can be predicted by radiomics. This work has implications for the use of imaging-based biomarkers in the clinic, as applied noninvasively, repeatedly, and at low cost. Cancer Res; 77(14); 3922–30. ©2017 AACR.
Emerging Data and Current Challenges for Young, Old, Obese, or Male Patients with Breast Cancer
Authors: Freedman Rachel A. , Partridge Ann H. 
Published: June 2017

Abstract
There are distinct subgroups of patients who have historically been underrepresented in most prospective clinical trials in breast cancer, including the youngest and oldest patients, male patients, and those struggling with obesity. Herein, we review current and future directions in research for each of these special populations with breast cancer, highlighting significant knowledge gaps and priorities in tumor biology and heterogeneity, therapeutic decision making promotion of adherence, supportive care, and psychosocial and functional well-being. In younger women, future study should focus on the biological underpinnings of aggressive disease and optimizing adherence and treatment decision making while addressing their unique survivorship needs. The latter includes generating a scientific basis for interruption of therapy for pregnancy. Among older patients, interventions should focus on increasing clinical trial accrual, predicting and mitigating toxicity so that functional status can be optimized, tailoring needs for dose modification, and anticipating life expectancy in the context of competing causes of death. For men with breast cancer, we need worldwide collaboration to answer even basic questions on optimal treatment, supportive care, and survivorship strategies. Finally, for those struggling with obesity, we need to better understand the biological associations with cancer incidence, prognosis and outcome, and how we can best intervene to assure weight loss at the “right time.” It is only through highly collaborative, far-reaching, prospective, multidisciplinary, patient-centered, and patient-engaged efforts that we can optimize the physical and psychologic outcomes for all patients with breast cancer. Clin Cancer Res; 23(11); 2647–54. ©2017 AACR.
See all articles in this CCR Focus section, “Breast Cancer Research: From Base Pairs to Populations.”