bluuebunny/crossref_metadata_2025_split huggingface dataset:
Indonesian Throughflow promoted eastward propagation of the Madden-Julian Oscillation
Authors: Liu Fei , Ma Libin , Li Mingting , Li Juan 
Published: October 2024

Abstract

Understanding the impacts of the Indonesian Throughflow (ITF) on the eastward propagation of the Madden-Julian Oscillation (MJO) is crucial for accurately simulating the MJO and achieving high-skill sub-seasonal predictions. Our analyses demonstrate a significant enhancement of MJO eastward propagation due to the strong ITF. Blocking the ITF decreases the eastward sea surface temperature (SST) gradient over the tropical Indian Ocean, hindering MJO propagation across the Maritime Continent (MC). Removing the MJO circulation-induced intraseasonal variability of the ITF transport also weakens the eastward propagation of the MJO, as the MJO easterly winds enhance the ITF transport and warm the eastern tropical Indian Ocean. These experiments reveal that mean and intraseasonal variability of the ITF transport contribute to 73% and 42% of the eastward propagation of the MJO over the MC, respectively. The findings presented in this study highlight the significant role of the ITF in shaping the propagation of the MJO.
The Effect of Endometrial Thickness on The Day of Human Chorionic Gonadotropin Injection on Reproductive Outcome in Clomiphene Citrate and Intrauterine Insemination Cycles
Authors: Aksan Alperen , Dilbaz Berna , Erturun Ayse Gülen , Dilbaz Serdar , Sarıkaya Dilara 
Published: October 2024

Abstract

Backround:
To evaluate the effect of endometrial thickness (EMT) on the day of Human Chorionic Gonadtropin(hCG) injection on reproductive outcome in clomiphene citrate and intrauterine insemination cycles (CC + IUI).
Methods
Overall 640 cycles in couples with unexplained infertility or WHO Category 2 normogonadotropic anovulatory women and met the inclusion criteria were analyzed retrospectively. Our study was approved by Ministry of Health, Health Sciences University Etlik Zübeyde Hanim Women’s Institutional Board (30/12/2020-90057706-799) who applied to Reproductive Endocrinology Department of a tertiary center between February 2019 and February 2020 and received ovulation induction with CC + IUI. The demographic characteristics and EMT at the hCG injection day were compared in the group with a clinical pregnancy with those who failed to achieve pregnancy.
Results
Out of the evaluated 640 cycles, 92 cases had a high β-hCG (14.4%) and 80 (12.5%) resulted in a clinical pregnancy. While 23 (23/640, 3.6%) of the cases with clinical pregnancy experienced spontaneous abortion, 52 (8.1%) resulted in live birth. Maternal age, duration of infertility and clomiphene citrate dosage were found to have an impact on the clinical pregnancy and live birth ratio. The cut-off value for endometrial thickness is 8.45 mm (sensitivity 49.4%, specificity 55.3%) for clinical pregnancy. The incidence of biochemical pregnancy was less while the incidence of clinical pregnancy (p = 0.010) and live birth (p = 0.002) was high in cases with an EMT > 8–9 mm on the day of β-HCG injection
Conclusion
Higher pregnancy rates have been reported at certain EMT values. However, cycle success can be predicted not only by EMT but also by considering other factors such as female age, infertility duration, and endometrial pattern.
The impact of preoperative maintaining antithrombotic medications for clinical outcomes in patients undergoing non-coronary endovascular interventions
Authors: Li Jiaqi , Fu Linlin , Zhang Yepeng , Qiao Tong , Wang Baoyan 
Published: October 2024

Abstract

It is common for patients on antithrombotic medications to undergo endovascular interventions. This study aimed to evaluate the effects of preoperative maintaining antithrombotic medications on perioperative clinical outcomes, especially intraoperative blood transfusion, in patients undergoing these procedures. A total of 5743 patients who underwent endovascular interventions from January 2019 to December 2022 were identified and divided into four groups based on the preoperative antithrombotic medications. Clinical outcomes, including blood transfusion, hematoma and pseudoaneurysm, were analyzed using multivariate logistics regression. Subsequently, patients were stratified according to whether they received blood transfusion. All-cause mortality, adverse cardiovascular events and infectious events were used to evaluate the impact of blood transfusion. The stabilized inverse probability of treatment weights (IPTW) with using propensity score was employed to adjust for covariate imbalance. Compared to patients not receiving any antithrombotic medications, those undergoing dual antiplatelet therapy or anticoagulant therapy exhibited an increased risk of requiring blood transfusion (OR: 2.05, 95%CI: 1.30-3.23; OR: 1.92, 95%CI: 1.22-3.03). Additionally, patients receiving anticoagulant therapy demonstrated a higher risk of hematoma (OR: 2.71, 95% CI: 1.20-6.13). No significant difference in the incidence of pseudoaneurysm was observed. Subgroup analysis indicated that the risk of blood transfusion varied according to the type of anesthesia, number of puncture sites and renal function, with a significant interaction (P < 0.05). Patients who required blood transfusion had significantly higher rate of one-year all-cause mortality (HR: 2.18, 95% CI: 1.10-4.32) and three-month infectious events at three months (HR: 4.92, 95% CI: 1.72-14.06). Preoperative maintaining dual antiplatelet or anticoagulant therapy increased the risk of blood transfusion in endovascular interventions. Blood transfusion was independently associated with increased risk of all-cause mortality and infectious events. Interventional physicians should assess thrombosis and bleeding risks preoperatively, and determine whether to discontinue antithrombotic medications and avoid liberal blood transfusion.
C–C motif chemokine ligand 14 characterization for prediction of persistent severe AKI in post-cardiac surgery children
Authors: Brandewie Katie , Alten Jeffrey A , Goldstein Stuart L. , Rose James , Kim Michael E , Ollberding Nicholas J. , Zang Huaiyu , Gist Katja M 
Published: October 2024

Abstract

Objectives Evaluate the association of early postoperative urinary c-c motif chemokine ligand 14 (CCL14) and persistent severe acute kidney injury (AKI) in pediatric post-cardiac surgery patients.Methods Retrospective single center cohort study of patients < 18 years of age undergoing cardiac surgery who provided a biorepository urine sample within the first 24 postoperative hours. Persistent severe AKI was defined as any AKI stage lasting for ≥ 72 hours with at least one time point of AKI stage 2 or 3 during that time frame. Patients with persistent severe AKI were matched 2:1 with non-AKI patients on age and sex. Urine samples were measured for CCL14 concentration. Logistic regression was used to evaluate associations between CCL14 and persistent severe AKI.Results Persistent severe AKI occurred in 14 (5.4%) patients and was more common in patients with higher surgical complexity and longer cardiopulmonary bypass and cross-clamp duration. Patients with persistent severe AKI had longer median cardiac intensive care unit (CICU) (5 [3, 10] vs. 2 [1.5, 5.5], p-value = 0.039) and hospital length of stays (13.5 [7.8, 16.8] vs. 6 [4, 8], p-value = 0.009). There was no difference in CCL14 levels between patients with and without persistent severe AKI (46.7 pg/ml [31.0, 82.9] vs. 44.2 pg/ml [25.1, 74.9], p-value = 0.49) in univariable and logistic regression.Conclusions In this heterogenous cohort of children undergoing cardiac surgery, CCL14 was not associated with persistent severe AKI. Future studies are needed to evaluate the use of CCL14 for predicting persistent severe AKI in children
Re-evaluating the timing of sequential cranial ultrasound screening in very preterm infants for predicting neurodevelopmental outcomes: A Population Study
Authors: Ramdass Sunaina , Disher Tim , Vincer Michael , Afifi Jehier , Ahmad Tahani 
Published: October 2024

Abstract

Objective:
The accurate prediction and early detection of neurodevelopmental impairment (NDI) is a crucial endeavor in caring for very preterm infants (VPI). Sequential cranial ultrasound (CUS) is the standard of care for imaging evaluation. There is no consensus on the timing and frequency of CUS screening. At our institution four time points CUS are performed for screening. We hypothesize that the 2-week CUS is not necessary for NDI prognostication.
Materials and methods:
In this retrospective, multi-center, population-based cohort, we included all liveborn VPI born 220-306 weeks gestation between January 2004 and December 2018 who had a neurodevelopmental assessment at 36 months corrected age. A model with and without 2-week CUS was compared to a reference model including gestational age, infant sex, and 6-week CUS.
Results:
Out of 786 preterm babies born during the study period, 656 survivors were included in the analysis. 30% of our cohort has NDI as per clinical assessment. The mean gestational age was 27.8 weeks with the mean birth weight being 1133 grams, and 55% being male infants. One in three survivors developed NDI when assessed at 36 months of corrected age.
There was no strong evidence that the addition of the 2-weeks CUS meaningfully contributes to the risk prediction of any NDI or major NDI. Models with and without the 2-week CUS showed nearly identical performance across a broad set of metrics.
Conclusion:
The comparison of two methods of sequential CUS screening showed reliable performance of the 3-time points model to predict NDI at 36 months of corrected age.
The efficacy and safety analysis of immunotherapy combined with chemotherapy with or without targeted therapy versus chemotherapy alone as second-line treatment for advanced biliary tract malignant tumors
Authors: Jiang Chengzhi , Yang Liu , Kong LingYang , Fang Tianyuan , Chang Lele , He Lei , Ma Qian , Cheng YiBo , Wang Wanying , Ma Zhigang , Li Qingwei , Tao Ji 
Published: October 2024

Abstract

Objective
The treatment of biliary tract cancer (BTC) keep still limited, especially after the progress of first-line treatment. Immune checkpoint inhibitors (ICIs) have been proved effects in various of solid tumors, so as BTC. But their efficacy and safety in patients with advanced BTC are still need further exploration.
Methods
The clinical information of 126 patients diagnosed with advanced BTC between 2014 and 2024 who received the first-line therapy or neoadjuvant therapy but assessing progress or intolerance were retrospectively reviewed. All patients were treated with chemotherapy, while 57 of them were treated with ICIs in combination targeted therapy or not, the other 69 of them were not. Therefore, we divided the patients into two groups, SC (simple chemotherapy) and CT (combined treatment), then we analyzed the benefit of adding ICIs with or without targeted therapy according to efficacy, adverse events, progression-free survival (PFS), overall survival (OS), progressive disease (PD), and the influence of various factors and effectiveness.
Results
The mean PFS was 4.68 months for CT group and 3.50 months for SC group. And the mean OS was 30.26 months for CT group and 17.14 months for SC group. The PFS and OS were prolonged by 1.18 months and 13.12 months with ICIs with or without targeted therapy respectively, and the difference were statistically significant (p = 0.0012; p < 0.001). The objective response rate (ORR) was 5.26% (3/57) for the CT group versus 1.45% (1/69) for the SC group, and the disease control rate (DCR) was 54.39% (31/57) versus 33.33% (23/69), respectively. Regression analysis demonstrated that factors such as TNM stage, T stage, histological grade, whether CA199 decreased, and therapeutic evaluation grade were related to OS (p < 0.05). For the treatment-related adverse events (TRAEs), the highest grade 3–4 adverse effects was hemoglobin count decreased (29.37%).
Conclusion
Our study showed that ICIs combined with chemotherapy with or without targeted therapy exhibited good antitumor activity with acceptable safety and could be recommended as second-line treatment for patients with advanced BTC.
Effect of tele-training tai chi versus strength exercise on markers of oxidative stress and muscle mass in older Mexican women during the COVID-19 pandemic
Authors: Hernández-Álvarez David , Rosado-Pérez Juana , Gavia-García Graciela , Arista-Ugalde Taide Laurita , Aguiñiga-Sánchez Itzen , Osorio Edelmiro Santiago , Vaquero-Barbosa Nayeli , Mendoza-Núñez Víctor Manuel 
Published: October 2024

Abstract

Background Physical exercise teletrining can be a good option to maintain intrinsic capacity, especially in confinement situations such as the one experienced during the COVID-19 pandemic. To determine the effect of tele-training tai chi vs. strength exercise on markers of oxidative stress and muscle mass in Mexican older adults during the COVID-19 pandemic. Methods A quasi-experimental exploratory study of a convenience sample of 38 older women who participated in a zoom tele-exercise program, divided into two groups: (i) tai chi group (TCG) n = 19; (ii) strength training group (STG) n = 19. All participants had blood markers of oxidative stress (OxS), inflammation and body composition parameters assessed at baseline and after six months of tele-exercise training. Results Adherence to the tele-training by zoom program was observed in more than 80% of the participants. A statistically significant decrease in the concentration of carbonylated proteins was found in the TCG compared to the STG (TCG, baseline 47.30 ± 5.16, post. 37.09 ± 12.90 vs. STG, baseline, 35.64 ± 13.96, post. 47.68 ± 16.85, p < 0.05), in addition to a decrease in the oxidative stress index (TOS/TAS) in the TCG compared to the STG (TCG, base-line, 9.34 ± 6.88, Post. 5.79 ± 3.95 vs. GST, baseline 5.35 ± 2.39, post 13.24 ± 7.07, p < 0.01). Likewise, a greater increase in the ratio of free fat mass and skeletal muscle mass was observed in the TCG compared to the STG with borderline statistical significance (p = 0.06). Conclusion Our findings suggest that tai chi tele-training by zoom has a significantly greater antioxidant effect than ST linked to an increase in fat-free mass and skeletal muscle mass. Therefore, the use of remote digital platforms, such as zoom, may be an option for healthy aging interventions through the tai chi tele-training to maintain or improve intrinsic capacity.
Unravelling Africa’s raw material footprints and their drivers
Authors: Osei-Owusu Albert , Danquah Michael , Towa Edgar , Cabernard Livia 
Published: October 2024

Abstract

African economies, reliant on resource extraction and exports, face rising demand for their critical minerals essential to the green transition and net-zero targets. To capitalise on these opportunities, Africa must address environmental concerns and regulatory, technological, and financial challenges in decoupling growth from resource use while pursuing decarbonisation. This study applies an environmentally extended input-output analysis, leveraging the Resolved Exiobase database, to estimate the global raw material footprints of 51 African nations from 1995 to 2018. It employs the least absolute shrinkage and selection operator and panel regression models to quantify the effects of diverse variables on these footprints. The findings showed that the raw material footprints of Africa’s production and consumption grew by 60 per cent (3.65-5.76 Gt) and 58 per cent (2.85-4.55 Gt), respectively, from 1995 to 2018, mainly due to biomass and non-metallic minerals. Our findings also show that Africa’s share of outsourced consumption footprints increased from 14-32% over the studied period, while over 40% of its production footprint embodied in exports. These findings underscore the urgent need for policy reforms in Africa to address the challenges of resource overexploitation, extreme rent-seeking and bad governance. Such reforms are critical for decoupling economic growth from Africa’s material consumption and its related environmental impacts to achieve sustainable development in the region.
Research on Student Performance Prediction Based on Deep Learning
Authors: Xu Wenjin , Gao Chang , Yang Hongning 
Published: October 2024

Abstract

Student performance serves as a crucial indicator for assessing learning outcomes across various educational institutions. Conducting reasonable predictions and analyses can provide insights into students' future academic achievements. Predicting student performance is a significant research direction in the current exploration of educational data analysis patterns. Accurate predictions can assist educational administrators and teachers in promptly identifying academic risks, optimizing the allocation of scarce educational resources, and consequently improving education quality and learning outcomes. This paper establishes a Convolutional Neural Network (CNN) prediction model, constructing training and testing datasets using PyTorch tensors based on existing student information data. By extracting target information columns, the model identifies patterns within the data and ultimately predicts a student's score in a specific subject for their next exam. Upon completing the predictions, the results are displayed in a chart alongside existing scores for analysis, providing a reference for developing subsequent training programs.
Inhibition of TFF3 Synergizes with c-MET Inhibitors to Decrease the CSC-like Phenotype and Metastatic Burden in ER+HER2+ Mammary Carcinoma
Authors: Lobie Peter , He Chuyu , Wang Xuejuan , Chiou Yi-Shiou , Basappa Basappa , Zhu tao , Pandey Vijay 
Published: October 2024

Abstract

The interaction between HER2 and ERα signaling pathways contributes to resistance to anti-estrogen and HER2-targeted therapies, presenting substantial treatment challenges in ER-positive (ER+) HER2-positive (HER2+) mammary carcinoma (MC). Trefoil Factor-3 (TFF3) has been reported to mediate resistance to both anti-estrogen and anti-HER2 targeted therapies in ER+ and ER+HER2+ MC, respectively. Herein, the function and mechanism of TFF3 in ER+HER2+ MC was delineated; and novel combinatorial therapeutic strategies were identified. Elevated expression of TFF3 promoted the oncogenicity of ER+HER2+ MC cells, including enhanced cell proliferation, survival, anchorage-independent growth, 3D growth, cancer stem cell-like (CSC-like) phenotype, invasion, migration, and xenograft growth. Targeting TFF3 with an interfering RNA plasmid or a small-molecule inhibitor (AMPC) inhibited these oncogenic characteristics, highlighting the therapeutic potential of targeting TFF3 in ER+HER2+ MC. Furthermore, a high-throughput combinatorial anti-cancer compound library screening revealed that AMPC preferentially synergized with receptor tyrosine kinase c-MET inhibitors (c-METis) to reduce cell survival and the CSC-like phenotype. The combination of AMPC and c-METis also synergistically suppressed in vivo growth of ER+HER2+ MC cell-derived xenografts and abrogated lung metastasis. Mechanistically, TFF3 was observed to activate c-MET signaling through a positive-feedback loop to enhance the CSC-like phenotype of ER+HER2+ MC. Therefore, proof of concept is provided herein that antagonizing of TFF3 is a promising therapeutic strategy in combination with c-MET inhibition for the treatment of ER+HER2+ MC.
Identification of the factors influencing the liquid sloshing wave height in a sloped bottom tank under horizontal excitation using PCA approach
Authors: Ren Wenhao , Zhong Zuowei 
Published: October 2024

Abstract

The dynamic behavior of liquid storage tanks represents a pivotal research area concerning structural safety and reliability. Notably, sloped bottom tanks exhibit heightened sloshing with reduced liquid mass compared to rectangular counterparts. This study adopts a hybrid approach that seamlessly integrates the linear potential-flow theory, renowned for its analytical rigor in fluid dynamics modeling, with principal component analysis (PCA), a potent technique for dimensionality reduction and feature extraction. The hybrid methodology initially employs the linear potential-flow theory to simulate the fundamental fluid dynamics within sloped bottom tanks subjected to horizontal excitation. Subsequently, PCA is applied to the simulated data, identifying key components of liquid sloshing wave height variations. Through the analysis of these principal components, an accurate model of the maximum sloshing wave height is derived, achieving a close correlation with ANSYS simulation results, exhibiting a correlation coefficient of 0.98 and a mean absolute error of 2.5%. This approach uniquely facilitates the evaluation of the intricate interplay between multiple factors, including tank geometry and excitation frequency, on the dynamic characteristics of liquid sloshing waves in sloped bottom tanks. The findings emphasize the significant influence of tank height and tilt angle, with a sensitivity analysis indicating a 4.07% increase in maximum wave height per degree increase in tilt angle under specified experimental conditions. This comprehensive methodology not only enhances understanding of the complex liquid sloshing phenomenon but also provides precise theoretical and practical guidance for fluid sway control strategies. Future investigations will further expand the scope and elucidate the fundamental mechanisms governing liquid sloshing dynamics.
Optimizing Concrete Sustainability: Impact of Bagasse Ash and Stone Dust on Mechanical Properties and Durability
Authors: Khan Muhammad Adeel , Zhang Boshan , Ahmad Mahmood , Niekurzak Mariusz , Khan Muhammad Salman , Sabri Mohanad Muayad Sabri , Chen Weizhen 
Published: October 2024

Abstract

Effectively managing and reducing industrial and municipal waste is crucial for addressing environmental issues like pollution and resource depletion. Since cement production is a major contributor to greenhouse gases, using eco-friendly building materials becomes essential in the fight against global warming and for a more sustainable future. This research proposes an innovative approach to concrete technology by concurrently exploring the use of SCBA and SD as partial replacements for cement and sand at varying ratios in eco-strength concrete mixes for 28 and 34 MPa. This combination of materials will help to evaluate the economic and environmental benefits of using these alternative materials, such as reduced reliance on traditional cement and sand resources, potential cost savings, and the mitigation of environmental impacts through waste utilization. The influence of BA and SD on workability, mechanical properties, and durability were experimentally investigated. The introduction of 9% SCBA as a substitute for cement and 40-50% SD as a replacement for sand leads to a substantial enhancement in both compressive and tensile strength. This improvement is attributed to factors such as pozzolanic reactions, enhanced particle packing, and optimal curing conditions. Additionally, a notable increase in flexural strength is observed with 6% cement replacement using SCBA and 40% sand replacement with SD. However, it is observed that as the ratios of SCBA and SD increase, there is a concurrent rise in water absorption. The findings reveal that the optimized mix, derived from response surface analysis, closely aligns with the control mix in terms of mechanical strengths, emphasizing its appropriateness for structural applications.