bluuebunny/crossref_metadata_2025_split huggingface dataset:
MAIT cells accumulate in placental intervillous space and display a highly cytotoxic phenotype upon bacterial stimulation
Authors: Solders Martin , Gorchs Laia , Erkers Tom , Lundell Anna-Carin , Nava Silvia , Gidlöf Sebastian , Tiblad Eleonor , Magalhaes Isabelle , Kaipe Helen 
Published: July 2017

AbstractDuring pregnancy, the maternal immune system must tolerate the developing foetus, and yet retain a potent antimicrobial response to prevent infections. Mucosal associated invariant T (MAIT) cells recognize microbial-derived vitamin B metabolites presented on the MR1 molecule, but their presence and function at the foetal-maternal interface is not known. We here isolated mononuclear cells from paired samples of peripheral blood (PB), intervillous blood (IVB), and decidua parietalis (DP) following uncomplicated term pregnancies. Interestingly, MAIT cells were highly enriched in IVB compared to PB and DP. The activation status of IVB MAIT cells was similar to that of PB MAIT cells, except for a lower expression of PD-1. Both IVB MAIT cells and conventional T cells were more dominated by an effector memory phenotype compared to PB MAIT cells and T cells. IVB MAIT cells also responded more vigorously with expression of IFN-γ, granzyme B, and perforin in response toEscherichia colistimulation compared to PB. MR1 was not expressed in syncytiotrophoblasts, but in placental villous and decidual macrophages. These data indicate that maternal MAIT cells accumulate in the intervillous space of the placenta and that they are highly armed to quickly respond if bacteria are encountered at the foetal-maternal interface.
Trypanosoma brucei growth control by TNF in mammalian host is independent of the soluble form of the cytokine
Authors: Vanwalleghem Gilles , Morias Yannick , Beschin Alain , Szymkowski David E. , Pays Etienne 
Published: July 2017

AbstractInfection of C57Bl/6 mice by pleomorphic African trypanosomesTrypanosoma brucei and T. congolenseis characterized by parasitemia waves coupled with the production of systemic levels of TNF. This cytokine is known to controlT. bruceigrowth, but also to contribute to tissue damage, shortening the survival time of infected mice. Using a dominant-negative version of TNF to discriminate between the effects of the membrane-form versus the soluble form of TNF, we show that the second form is involved in neither parasite control nor induction of liver injury. Therefore, soluble TNF is likely not a major contributor to disease outcome. We propose that membrane-bound TNF is responsible for bothT. bruceicontrol and host pathology.
Scenarios of polaron-involved molecular adsorption on reduced TiO2(110) surfaces
Authors: Cao Yunjun , Yu Min , Qi Shandong , Huang Shiming , Wang Tingting , Xu Mingchun , Hu Shujun , Yan Shishen 
Published: July 2017

AbstractThe polaron introduced by the oxygen vacancy (Vo) dominates many surface adsorption processes and chemical reactions on reduced oxide surfaces. Based on IR spectra and DFT calculations of NO and CO adsorption, we gave two scenarios of polaron-involved molecular adsorption on reduced TiO2(110) surfaces. For NO adsorption, the subsurface polaron electron transfers to a Ti:3d-NO:2p hybrid orbital mainly on NO, leading to the large redshifts of vibration frequencies of NO. For CO adsorption, the polaron only transfers to a Ti:3d state of the surface Ti5c cation underneath CO, and thus only a weak shift of vibration frequency of CO was observed. These scenarios are determined by the energy-level matching between the polaron state and the LUMO of adsorbed molecules, which plays a crucial role in polaron-adsorbate interaction and related catalytic reactions on reduced oxide surfaces.
Differentiating malignant from benign thyroid nodules with indeterminate cytology by 99mTc-MIBI scan: a new quantitative method for improving diagnostic accuracy
Authors: Campennì A. , Siracusa M. , Ruggeri R. M. , Laudicella R. , Pignata S. A. , Baldari S. , Giovanella L. 
Published: July 2017

AbstractQuantitative99mTc-MIBI thyroid scintigraphy is a useful tool in differentiating malignant from benign thyroid nodules with indeterminate cytology. The aim of our report is to compare the diagnostic performance of different quantitative methods. We prospectively evaluated 20 patients affected by a thyroid nodule with a cytological diagnosis of class III or IV according to the Bethesda system. Planar images of the thyroid were acquired 10 and 60 minutes after99mTc-MIBI administration and two different quantitative methods applied (i.e. wash-out index, WOind;retention index, R.I.). All patients underwent lobectomy or thyroidectomy and final histological findings were matched with MIBI results obtained with both quantitative methods. Four out of 20 patients had a final histological result of differentiated thyroid cancer, while benign findings were found in the remaining cases. Overall sensitivity, specificity, accuracy, PPV and NPV were 100% in all for the WOindand 100%, 57.1%, 62.5%, 25% for the R.I., respectively. In conclusion99mTc-semiquantitative MIBI thyroid scintigraphy with WOindcalculation is highly accurate in differential diagnosis of nodules with indeterminate cytology reading.
Interprofessional Peer-Assisted Learning as a Model of Instruction in Doctor of Audiology Programs
Authors: Serpanos Yula C. , Senzer Deborah , Gordon Daryl M. 
Published: July 2017

Purpose
This study reports on interprofessional peer-assisted learning (PAL) as a model of instruction in the preparation of doctoral audiology students.

Method
Ten Doctor of Audiology (AuD) students provided training in audiologic screening for 53 graduate speech-language pathology students in 9 individual PAL sessions. Pre- and post-surveys assessed the peer teaching experience for AuD students in 5 areas of their confidence in audiologic screening: knowledge, skill, making a referral based on outcomes, teaching, and supervising. Pre- and post-learning outcomes in audiologic screening for the speech-language pathology student trainees determined the effectiveness of training by their AuD student peers.

Results

Survey outcomes revealed significant (
p
< .001) improvement in the overall confidence of AuD student peer instructors. Speech-language pathology students trained by their AuD peers exhibited significant (
p
= .003) improvements in their knowledge and skill and making outcome-based referrals in audiologic screening, supporting the effectiveness of the PAL paradigm.

Conclusions
In addition to meeting required accreditation and professional certification competency standards, the PAL instructional model offers an innovative curricular approach in interprofessional education and in the teaching and supervisory preparation of students in doctoral audiology programs.
“New York just like I pictured it – skyscrapers and everything”
Authors: Katrina Gutierrez Anna 
Published: July 2017

Abstract
Maps of New York City, whether visual or verbal, evoke an abundance of scripts and schemas related to adolescent romance, adventure, and coming-of-age. Some of these are associated with iconic sights, for example, the Empire State Building and the ‘romantic rendezvous’ script. In these texts New York is a storyworld grounded on a map that exists outside of the narrative but is built from the blend of disparate New York schemas: those called upon by the focalizing characters and those held in the mind of the reader. In Nick and Norah’s Infinite Playlist (2006) and Dash and Lily’s Book of Dares (2010), the coming-of-age romance begins with a map, and the mapping of script onto storyworld is enriched by intertextual links with music, poetry, and literature. The intertextual meaning-making combined with the active blending of New York City schemas that occur in the background emphasize the complexity of intersubjective development.
Mapping illusions
Authors: Mikhaylova Olga 
Published: July 2017

Abstract
This chapter examines the artistic functions of the visual and verbal depiction of a child’s fantasy country in Lev Kassil’s novel Sсhwambrania (1933) against the background of the state’s interest in geography and cartography. After a short overview of the political circumstances that accompanied the reforms in Soviet cartography, this chapter applies Harley’s approach to the interpretation of the two maps of the child’s fantasy world of Sсhwambrania, considering the graphic and linguistic components of these maps and their description in the text, and, in addition, reconstructing the different types of context relevant to Kassil’s book.
Epistemic buck-passing and the interpersonal view of testimony
Authors: Baker Judith , Clark Philip 
Published: July 2017

AbstractTwo ideas shape the epistemology of testimony. One is that testimony provides a unique kind of knowledge. The other is that testimonial knowledge is a social achievement. In traditional terms, those who affirm these ideas are anti-reductionists, and those who deny them are reductionists. There is increasing interest, however, in the possibility of affirming these ideas without embracing anti-reductionism. Thus, Sanford Goldberg uses the idea of epistemic buck-passing to argue that even reductionists can accept the uniqueness of testimonial knowledge, and Jennifer Lackey gives both speaker and hearer an essential role in testimonial justification, rejecting both reductionism and anti-reductionism in favor of what she calls dualism. After distinguishing a weaker and a stronger notion of buck-passing, we show how anti-reductionists can use the stronger notion to motivate their position, and to answer Goldberg’s and Lackey’s challenges.
Evaluating Head-of-Reservoir Water Temperature for Juvenile Chinook Salmon and Steelhead at Shasta Lake with Modeled Temperature Curtains
Authors: Clancey Katherine , Saito Laurel , Hellmann Kurt , Svoboda Connie , Hannon John , Beckwith Randy 
Published: July 2017

Abstract
Loss of historical spawning and rearing habitat in the rivers and tributaries of California's Central Valley is one of the factors that led to the listing of Chinook Salmon Oncorhynchus tshawytscha and steelhead O. mykiss under the Endangered Species Act. To recover these salmonid populations, an interagency committee is developing a plan to reintroduce fish to tributaries upstream of Shasta Dam and provide juvenile fish passage downstream past the dam. One downstream fish passage alternative involves the collection and transport of juvenile fish from head-of-reservoir locations. A hydrodynamic and water quality model (CE-QUAL-W2) of Shasta Lake and its main tributaries was used to assess where and when water temperatures were favorable for juvenile salmonid collection on the McCloud River arm of the lake under different hydrologic scenarios. The application of anchored and floating temperature curtains (i.e., flexible fabric flow barriers) was examined to assess whether they could be used to improve temperature conditions for juvenile fish by reducing temperatures to within an optimal range. Model results indicated that head-of-reservoir conditions without a temperature curtain were suitable for spring-run Chinook Salmon, fall-run Chinook Salmon, and steelhead but not for winter-run and late-fall-run Chinook Salmon. However, permanent or temporary use of temperature curtains, especially a long floating curtain, may improve conditions for juvenile winter-run and late-fall-run Chinook Salmon by reducing or eliminating lethal water temperatures.
Received January 28, 2017; accepted June 26, 2017 Published online September 8, 2017
Enhanced rutin accumulation in tobacco leaves by overexpressing the NtFLS2 gene
Authors: Shi Junli , Li Wenzheng , Gao Yulong , Wang Bingwu , Li Yong , Song Zhongbang 
Published: July 2017

Abstract
Rutin, one of the metabolites of the flavonoid pathway, shows great potential in industrial applications as a key component in pharmaceutical medicines and biological pesticides. Although the genetic manipulation of transcription factors (TFs) could increase rutin levels in plants, the accompanying accumulation of structurally similar chemicals complicates industrial rutin extraction. In this study, we demonstrated remarkably elevated rutin content (3.5-4.4-fold relative to controls) in transgenic tobacco plants by overexpressing NtFLS2. The levels of other intermediates in the branch pathway did not change much except for a moderate increase of kaempferol-3-O-rutinoside. Furthermore, the transcript levels of pathway genes in transgenic lines were comparable with controls, indicating genetic engineering did not significantly alter the branch pathway. Additionally, the transgenic tobacco plants appeared normal except for a flower color change from light red to white suggesting that it could be a valuable material for industrial extraction of rutin.
Sixth International Zooplankton Production Symposium: new challenges in a changing ocean
Authors: Dalpadado Padmini , Gislason Astthor 
Published: July 2017

Abstract
The Sixth Zooplankton Production Symposium (ZPS) was organized to create an arena to discuss state of the art research on marine zooplankton. Eight sessions and seven workshops of broad scope were held at the conference to explore themes such as the role of zooplankton in marine food webs, response on production and biodiversity to climate change, use of new monitoring technologies, and the potential for zooplankton harvesting. It is the largest international symposium specifically devoted to research on zooplankton that has enabled participants to come together and disseminate findings from the world seas. The ZPS served as a global platform for international scientific collaboration to explore zooplankton dynamics, structure, and function in a changing ocean.
Prognostic biomarkers in oral squamous cell carcinoma: a systematic review
Authors: Rivera César , de Oliveira Ana Karina , Pereira e Costa Rute Alves , Rossi Tatiane De , Paes Leme Adriana Franco 
Published: July 2017

ABSTRACTOver the years, several tumor biomarkers have been suggested to foresee the prognosis of oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articles reporting overall survival, disease-free survival and cause-specific survival as outcomes. Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies.
Genetic and Environmental Contributions to The Association Between Violent Victimization and Major Depressive Disorder
Authors: Kavish Nicholas , Connolly Eric J. , Boutwell Brian B. 
Published: July 2017

AbstractResearch suggests victims of violent crime are more likely to suffer from major depressive disorder (MDD) compared to non-victims. Less research has utilized longitudinal data to evaluate the directionality of this relationship or examined the genetic and environmental contributions to this association across the life course. The current study evaluated 473 full-sibling pairs and 209 half-sibling pairs (N= 1,364) from the National Longitudinal Survey of Youth (Mage= 20.14, SD = 3.94). Cross-lagged models were used to examine the directionality of effects between violent victimization and MDD over time. Biometric liability models were used to examine genetic and environmental influences on single and chronic violent victimization and MDD. Violent victimization was associated with increases in MDD during late adolescence, but MDD was more associated with increased risk for violent victimization across young adulthood. Biometric analysis indicated that 20% and 30% of the association between MDD and single and chronic victimization, respectively, was accounted for by common genetic influences. Results from the current study suggest individuals who exhibit symptoms of MDD are at higher risk for chronic victimization rather than developing MDD as a result of victimization. Shared genetic liability accounted for between 20 to 30% of this longitudinal relationship.
The activation loop residue serine 173 ofS.pombeChk1 kinase is critical for the response to DNA replication stress
Authors: Coulton Naomi , Caspari Thomas 
Published: July 2017

AbstractWhy the DNA damage checkpoint kinase Chk1 protects the genome of lower and higher eukaryotic cells differentially is still unclear. Mammalian Chk1 regulates replication origins, safeguards DNA replication forks and promotes fork progression. Conversely, yeast Chk1 acts only in G1 and G2. We report here that the mutation of serine 173 (S173A) in the activation loop of fission yeast Chk1 abolishes the G1-M and S-M checkpoints without affecting the G2-M arrest. Although Chk1-S173A is fully phosphorylated at serine 345 by the DNA damage sensor Rad3 (ATR) when DNA replication forks break, cells fail to stop the cell cycle. Mutant cells are uniquely sensitive to the DNA alkylation agent methyl- methanesulfate (MMS). This MMS sensitivity is genetically linked with the lagging strand DNA polymerase delta. Chk1-S173A is also unable to block mitosis when the G1 transcription factor Cdc10 is impaired. Serine 173 is equivalent to lysine 166 in human Chk1, an amino acid important for substrate specificity. We conclude that the removal of serine 173 impairs the phosphorylation of a Chk1 target that is important to protect cells from DNA replication stress.Summary statementMutation of serine-173 in the activation loop of Chk1 kinase may promote cancer as it abolishes the response to genetic alterations that arise while chromosomes are being copied.
Aging with intellectual and developmental disabilities and dementia in Manitoba
Authors: Shooshtari Shahin , Stoesz Brenda M. , Udell Leslie , Fenez Leanne , Dik Natalia , Burchill Charles , Sachs Elizabeth , Menec Verena 
Published: July 2017

Purpose
Information on the risk of dementia in aging persons with intellectual and/or developmental disability (IDD) in Manitoba, Canada is lacking. The purpose of this paper is to estimate dementia prevalence in adults with IDD.

Design/methodology/approach
Anonymized population-level health and non-health administrative data (1979-2012) contained in the Population Health Research Data Repository of the Manitoba Centre for Health Policy (MCHP) were linked to identify adults with IDD, and estimate the prevalence of dementia based on the presence of ICD codes. Prevalence of dementia was estimated for persons aged 18-55 years and 55+ years, and was reported by sex, type of residence, region of residence, neighbourhood income quintiles, and IDD diagnostic category.

Findings
Of the 8,655 adults with IDD identified, 8.1 per cent had an indication of dementia in their medical records; an estimate three times greater than that found for those without IDD (2.6 per cent). More than 17 per cent of Manitobans with IDD aged 55+ years had an indication of dementia, which was nearly twice the rate reported previously. Of those with IDD and dementia, 34.7 per cent lived in long-term care facilities.

Originality/value
Health and social support services are typically available to individuals with dementia aged 65+ years; thus, younger adults with IDD and dementia may not be eligible for those supports. To promote equity in health and access to care, dementia screening and increased supports for aging individuals with IDD are recommended.
Open innovation: effects from external knowledge sources on abandoned innovation projects
Authors: Tranekjer Tina Lundø 
Published: July 2017

Purpose
Innovation projects are often risky and costly. But not all innovation projects lead to commercialisation; some are abandoned, and these abandoned innovation projects can be classified as a waste of resources. Therefore, this paper studies the influence of different external sources and a firm’s decision to abandon an innovation project. The purpose of this paper is to provide a broader understanding of abandoned projects.

Design/methodology/approach
The data applied are quantitative data and the empirical background is the Danish Innovation Survey 2009. The sample consists of Danish manufacturing firms with ten employees or more (n=840). The results are based on logistic regression analysis.

Findings
Results reveal that firms should consider that the involvement of customers can lead them to abandon innovation projects. However, if firms combine customers with universities, it will decrease the likelihood of innovation projects being abandoned. A more in-depth analysis shows that the involvement of customers from “Europe” (countries in Europe excluding Denmark) and the “US” leads to innovation projects being abandoned while customers from “other countries” (the rest of the world, including China and India) have the opposite effect.

Originality/value
The contribution is to the limited literature on abandoned innovation projects by suggesting that the type of external sources is a significant factor in firms’ decisions to abandon innovation projects. The paper identifies that the involvement of certain external sources leads firms to decide to abandon innovation projects, and that the country of origin of the external sources is an important criterion to consider in relation to a firm’s decision to abandon innovation projects.
Effects of supply chain agility on profitability
Authors: Abdoli Bidhandi Reza , Valmohammadi Changiz 
Published: July 2017

Purpose
The purpose of this paper is to identify factors affecting agile supply chain and evaluate the effect of these factors on profitability. To that end, after reviewing the theoretical foundations of this field, the authors identified the factors affecting supply chain agility and profitability and provided an appropriate conceptual model to measure and verify this relationship.

Design/methodology/approach
A 48-item questionnaire was prepared and distributed among 270 members of staff and managers of the company from which 240 questionnaire were completed and returned. The response rate was 88 percent. Using exploratory factor analysis (EFA), 37 indicators were selected and redundant questions were excluded. Results were analyzed using the structural equation modeling technique, and the relationships between factors were obtained and the impact of each supply chain agility factor on profitability was determined and prioritized.

Findings
Through EFA, the indicators related to each supply chain agility factor and profitability were extracted and using the literature, supply chain agility indicators were classified in four factors of speed, responsiveness, competency and flexibility and the indicators related to profitability in one factor, and confirmatory factor analysis (CFA) was conducted accordingly. The CFA results showed that all four factors are significantly associated with profitability, and flexibility has the greatest impact on profitability, and speed has minimal impact on profitability.

Research limitations/implications
As this study has been done in the context of Iran, cautious should be taken to generalize the results.

Originality/value
Other studies have examined the effect of agility on business performance and the relationship between them but this study, by providing a comprehensive set of supply chain agility evaluation criteria and indicators and considering all its dimensions, intends to identify the factors affecting supply chain agility and evaluate and determine the effects of these factors on profitability and examine if supply chain agility affects profitability.