bluuebunny/crossref_metadata_2025_split huggingface dataset:
Age distribution characteristics of 1915 cases of otitis media with effusion in children
Authors: Li Mingyang , Chen Xiangyu , Xu Jingyue , Liu Zihan , Xie Cuncun , Jia Xiaodong , Ding Shaoguang , Wang Guangke , Liu Hongjian 
Published: September 2024

AbstractObjectiveObjective To study the age distribution characteristics of otitis media with effusion in children and provide a basis for the selection of the timing of tympanic membrane perforation repair in children.MethodsA total of 1915 children with otitis media with effusion who visited our hospital from 2017 to 2022 were collected and divided into 4 groups according to age, namely, infant group, preschool group, school-age group and adolescent group, to study the distribution characteristics of the age of onset of children with otitis media with effusion.ResultsThe peak age of children with otitis media with effusion in the preschool period of 4-6 years old was the peak age of children with otitis media with effusion. The number of visits for otitis media with effusion in children aged 7 years old showed an obvious decline “inflection point”, and the number of visits for otitis media with effusion in adolescent children after the age of 13 years old tended to be stable.ConclusionThe incidence of otitis media with effusion in children decreased significantly after the age of 7, and the number of visits for otitis media with effusion in children aged 13 years was close to that of adults. This conclusion provides a theoretical basis for the timing of tympanic membrane perforation repair in children.Short summaryThis study aims to investigate the characteristics of otitis media with effusion otitis media with effusion (OME) in children, focusing on the peak periods for treatment and surgical intervention, the “inflection point” in treatment trends, and the overall changing trends in OME. The findings will provide a foundation for determining the appropriate timing for surgical intervention in pediatric OME cases.
Constructing well-defined neural networks of multiple cell types by picking and placing of neuronal spheroids using FluidFM
Authors: Connolly Sinéad , Vulić Katarina , Zare-Eelanjegh Elaheh , Simonett Marta , Duru Jens , Ruff Tobias , Clément Blandine F. , Vörös János 
Published: September 2024

AbstractControlled placement of single cells, spheroids and organoids is important forin vitroresearch, especially for bottom-up biology and for lab-on-a-chip and organ-on-a-chip applications. This study utilised FluidFM technology in order to automatically pick and place neuronal spheroids and single cells. Both single cells and spheroids of interest could be selected using light microscopy or fluorescent staining. A process flow was developed to automatically pick and pattern these neurons on flat surfaces, as well as to deposit them into polydimethylsiloxane microstructures on microelectrode arrays. It was shown that highly accurate and reproducible neuronal circuits can be built using the FluidFM automated workflow.
Research report CERITER Clinical study - Stride One
Authors: Meyer Sarah , Limet Jan , Stevens Piet , Michielsen Marc 
Published: September 2024

AbstractObjectiveThis study investigates the short-term impact of the use of Ceriter Stride One on the quality of gait in patients rehabilitating after a cerebrovascular accident (CVA). Stride One is a smart insole that provides real-time audio feedback (cues) to the patient when performing a certain exercise. The goal of Stride One is to allow patients to practice walking more intensively and with higher quality during rehabilitation.MethodTen patients were offered therapy using Stride One for one week. The quality of the gait pattern was evaluated at the beginning and at the end of the week, with and without the use of Stride One. An additional evaluation was performed three to four days after the end of therapy without the use of Stride One. One patient was unable to complete the therapy due to a fall.ResultsBoth therapist and patient reported an improvement in the quality of the foot roll-off pattern in 100% of cases. This improvement was also objectively determined in the data measured by Stride One, with an average of 8% improvement on Stride One general quality parameter, and an average of 25% improvement on Stride One specific quality parameter for the specific patient. Furthermore, 89% of patients indicate that using Stride One helps them to understand their physiotherapist better, and 67% of patients indicate that they can practice more and better with Stride One.ConclusionPracticing one week with Stride One generates a positive clinical impact on the gait pattern. A lasting improvement in the gait pattern without using Stride One, three to four days after the intervention, could not be demonstrated in this short time period. Further research is needed to evaluate the effect of Stride One after more long-term use.Additional research questions are suggested.
Satellite glial cells modulate proprioceptive neuron activity in dorsal root ganglia
Authors: Rabah Yasmine , Agulhon Cendra 
Published: September 2024

AbstractProprioception, the sense of body and limb position, is mediated by proprioceptors and is crucial for important motor functions such as standing and walking. Proprioceptor cell bodies reside within the peripheral dorsal root ganglia (DRG) and are tightly enveloped by satellite glial cells (SGCs). SCGs express a number of Gqprotein-coupled receptors (GqGPCRs), but their functional consequences on proprioceptor activity is unknown. Using a combination of chemogenetics, genetics, Ca2+imaging, pharmacology, immunohistochemistry, and biochemistry, we provide evidence that SGC GqGPCR signaling is sufficient to drive purinergic receptor-mediated Ca2+responses in proprioceptor cell bodies. Our findings suggest a potential role for SGC GqGPCR signaling in shaping proprioceptor information processing. Furthermore, this demonstration of SGC-induced proprioceptor activation has profound implications with SGC GqGPCR signaling and purinergic receptors representing potential therapeutic targets for alleviating some proprioceptor and sensorimotor impairments associated with spinal muscular atrophy or Friedreich’s ataxia.
Perioperative albumin versus other fluids to prevent cardiac surgery associated kidney injury: a protocol for a systematic review and meta-analysis of randomised trials
Authors: Darlison Phoebe , Brown Alastair , Neto Ary Serpa , Pakavakis Adrian , Balachandran Mayurathan , Shehabi Yahya 
Published: September 2024

AbstractBackgroundAcute kidney injury is a common complication following cardiac surgery. Albumin infusions have been proposed as an intervention that reduce the risk of this complication, but existing data have shown heterogenous results. The recent completion of two randomised controlled trial of Albumin infusions in cardiac surgical patients provides the opportunity to conduct a systematic review and meta-analysis to improve the precision of the estimated treatment effect of Albumin infusions in cardiac surgery.MethodsWe will conduct a systematic review of randomised controlled trials that have evaluated the use of peri-operative Albumin infusions compared to comparator fluids in patient undergoing on-pump cardiac surgery. We will conduct a search of MEDLINE, EMBASE, CINAHL and Cochrane Central from inception to 22nd August. The review will be conducted and reported in accordance with the PRISMA 2020 statement. We will use a bayesian framework to estimate the treatment effect of albumin to prevent acute kidney injury defined according to the KDIGO criteria.ResultsThis systematic review has been prospectively registered on PROSPERO (CRD42024580170) and the formal search was conducted on 23rdAugust 2024. Title and abstract screening has commenced with data extraction to commence following the submission of the protocol.ConclusionThis systematic review will provide an updated systematic review and meta-analysis to inform clinicians about the role Albumin infusion in cardiac surgery.
Pyrotinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (PERSIST): A multicenter phase II trial
Authors: Cao Feilin , Ma Zhaosheng , Wu Zenggui , Wu Weizhu , Wang Ouchen , Cui Binbin , Zhu Xiaotao , Hao Jing , Ji Xiaochun , Li Zhanwen , Tao Deyou , Feng Qingjing , Lin Wei , Shi Dongbo , Shu Jingde , Zhou Jichun , Huang Shifen 
Published: September 2024

BackgroundApproximately one-third of patients with HER2-positive breast cancer experienced recurrence within 10 years after receiving 1 year of adjuvant trastuzumab. The ExteNET study showed that 1 year of extended adjuvant neratinib after trastuzumab-based adjuvant therapy could reduce invasive disease-free survival (iDFS) events compared with placebo. This study investigated the efficacy and safety of pyrotinib, an irreversible pan-HER receptor tyrosine kinase inhibitor, after trastuzumab-based adjuvant therapy in patients with high-risk, HER2-positive early or locally advanced breast cancer.MethodsThis multicenter phase II trial was conducted at 23 centers in China. After enrollment, patients received 1 year of extended adjuvant pyrotinib (400 mg/day), which should be initiated within 6 months after the completion of 1-year adjuvant therapy (trastuzumab alone or plus pertuzumab). The primary endpoint was 2-year iDFS rate.ResultsBetween January 2019 and February 2022, 141 eligible women were enrolled and treated. As of October 10, 2022, the median follow-up was 24 (interquartile range, 18.0-34.0) months. The 2-year iDFS rate was 94.59% (95% CI: 88.97-97.38) in all patients, 94.90% (95% CI: 86.97-98.06) in patients who completed 1-year treatment, 90.32% (95% CI: 72.93-96.77) in patients who completed only 6-month treatment, 96.74% (95% CI: 87.57-99.18) in the hormone receptor-positive subgroup, 92.77% (95% CI: 83.48-96.93) in the hormone receptor-negative subgroup, 96.88% (95% CI: 79.82-99.55) in the lymph node-negative subgroup, 93.85% (95% CI: 86.81-97.20) in the lymph node-positive subgroup, 97.30% (95% CI: 82.32-99.61) in patients with adjuvant trastuzumab plus pertuzumab, and 93.48% (95% CI: 86.06-97.02) in patients with adjuvant trastuzumab. The most common adverse events were diarrhea (79.4%), fatigue (36.9%), lymphocyte count decreased (36.9%), nausea (33.3%), and hand-foot syndrome (33.3%).ConclusionExtended adjuvant pyrotinib administrated after trastuzumab-based adjuvant therapy showed promising efficacy in patients with high-risk HER2-positive breast cancer. The follow-up is ongoing to determine the long-term benefit.
Bonding and antibonding electromagnetic coupling in two interacting toroidal metamolecules
Authors: Wu Tong , Evlyukhin Andrey B. , Tuz Vladimir R. 
Published: September 2024

The existence of a toroidal-like eigenmode and its electromagnetic coupling in a system of dielectric particles are studied. A constituent structure (metamolecule) is made of a ring consisting of the radial arrangement of several vertically standing dielectric disks (meta-atoms). In the eigenstate of the given metamolecule, the second-order term related to the exact electric dipole in the multipole decomposition is much greater than the first-order term. This eigenstate is defined as a toroidal-like mode. Then, the characteristics of a system (metamacromolecule) composed of two identical rings are studied in both eigen- and excited states to reveal the peculiarities of the toroidal-like mode coupling. Similar to the well-known electric dipole-dipole and magnetic dipole-dipole interactions, the interaction of toroidal-like modes also appears in symmetric (bonding) and antisymmetric (antibonding) forms. Their excitation in the metamacromolecule depends on the propagation direction and polarization of the irradiating wave. The manifestation of toroidal-like mode coupling is confirmed by checking the extinction cross section and near-field distributions obtained from the full-wave numerical simulation and microwave experiment. A clear understanding of the nature of toroidicity is important from the fundamental physics perspective and practical implementation of metamaterials operated in such exotic states.

Published by the American Physical Society
2024
Production of a
BB¯
bound state via
ϒ(4S)
radiative decays
Authors: Britto André L. M. , Abreu Luciano M. 
Published: September 2024

Motivated by recent theoretical predictions about the existence of a BB¯ bound state [also denoted as X(10550)], in this work we estimate the production of the S-wave B+B− molecule via ϒ(4S) radiative decays. In particular, we make use of effective Lagrangian approach and the compositeness condition to calculate the X(10550) production rate via ϒ(4S)→γX(10550) decays employing triangle diagrams. Our results show that the partial decay width of this reaction is of the order of 0.5–192 keV for a respective binding energy of 1–100 MeV, corresponding to a branching fraction of 10−5–10−3. These findings suggest that the existence of the X(10550) might be checked via the analysis of the mentioned decay in present and future experiments.

Published by the American Physical Society
2024
Boundary objects: sustainability reporting and the production of organizational stability
Authors: Fernández Chulián Manuel , Garcia-Torea Nicolas , Larrinaga Carlos , Bebbington Jan 
Published: September 2024

PurposeThe study investigates how sustainability reporting constructs a narrative about an organization that provides its members with a reality they can accept, with the consequence of producing organizational stability.Design/methodology/approachThe article reports a research engagement concerning the “backstage” of sustainability reporting in one Spanish savings bank, which the researchers engaged with for more than three years.FindingsThe article describes how sustainability reporting operates as a boundary object occupying the space between the organization’s loosely coupled systems and facilitating the cooperation of members with different interpretations of the organization. Different translations of discourses and actions ensure that the sustainability report conveys a ductile narrative that can be tailored to specific interpretations. At the same time, the editing inherent in sustainability reporting ensures that any narrative that may challenge the organization’s dominant perspective is ignored and marginalized. In this way, sustainability reporting produces a discourse that inscribes a narrative of the organization and eventually ensures organizational inertia.Research limitations/implicationsThe article highlights the relevance of investigating sustainability reports by exploring the backstage of their production rather than solely the final document.Originality/valueIn contrast to prior research that has been concerned with exploring the extent to which sustainability reporting is associated with organizational change, this study applies different lenses to show how and why sustainability reporting is implicated in the construction of the organization and the maintenance of its stability and inertia.
A second life for second-hand products: the role of anthropomorphism and taboo trade-offs
Authors: Wan Jing , Aggarwal Pankaj 
Published: September 2024

Purpose
Trade-offs that involve secular values of money and sacred human values are often seen as taboo. This paper aims to examine how consumers avoid making taboo trade-offs with anthropomorphized products, by choosing options that ensure the well-being of the humanized products, even at a financial cost to themselves.

Design/methodology/approach
The authors conducted five experiments, across different marketplace contexts (i.e. repairing, buying and selling), to test the broad generalizability of the extent to which consumers are willing to incur a financial cost due to concern for the well-being of anthropomorphized products.

Findings
The results reveal that consumers are willing to accept financially inferior options to protect the humanness endowed upon anthropomorphized products. The effect is mediated by consumers’ concern for the treatment of the anthropomorphized product. The effect is moderated by consumers’ trait empathy level, such that those low in empathy are willing to sacrifice human value for the sake of greater financial gain.

Research limitations/implications
Future research could examine, in the context of anthropomorphized products, if there are types of human values that are less inviolable, leading consumers to be more willing to trade them off for monetary gains.

Practical implications
The findings have direct implications for second-hand markets. For potential buyers of anthropomorphized products, they should signal concern for the product; for sellers, anthropomorphizing their products can reduce haggling behavior. From a sustainability perspective, consumers may be more motivated to repair or recycle their products if it is framed as “infusing new life” into their products.

Originality/value
This work highlights a novel effect of anthropomorphism: when marketplace decisions are involved, anthropomorphizing a product can introduce a tension between secular monetary values and sacred human values. To the best of the authors’ knowledge, this work is the first to show that consumers are willing to incur a monetary loss to protect the humanness of anthropomorphized product, driven by their concern for the proper treatment of such humanized products.
Embracing the gig workers performance: an empirical investigation of location-based gig workers
Authors: Guduru Shravani , Santhanam Nivethitha 
Published: September 2024

PurposeThe aim of the study is to investigate the impact of job characteristics on gig worker performance in India. In addition, this study examines the role of work–life balance as a mediator in exploring the impact of job characteristics, namely, flexibility and job autonomy and person–job fit on gig workers performance among location-based gig workers.Design/methodology/approachA total of 266 responses were collected by gig workers using a questionnaire-based survey. The responses were analyzed using the partial least square structural equation modeling technique.FindingsThe study results indicate that factors of job characteristics and person–job fit significantly enhance the gig worker performance and also finds work–life balance as significant mediator. These results provide evidence for the hypotheses, which emphasizes that these aspects will have a beneficial effect on the performance of gig workers.Originality/valueThis research contributes to the field of the gig economy by empirically examining the study factors to understand the work dynamics in flexible work arrangements. Based on the findings, the gig platforms and policymakers can formulate strategies for establishing job design for enhancing work–life balance, which subsequently enhances gig workers performance.
Connecting the dots: exploring the role of ebullient supervision in fostering knowledge sharing through curiosity and informal learning
Authors: Islam Talat , Ahmad Saima , Chaudhary Arooba 
Published: September 2024

PurposeThe purpose of this paper is to examine curiosity as a distal predictor of knowledge sharing facilitated by informal learning. It also probes the boundary conditions imposed by ebullient supervision in the influence of curiosity on knowledge sharing.Design/methodology/approachThe authors collected data through a two-wave survey of 349 knowledge workers in the IT sector and used structural equation modeling to analyze the data.FindingsThe results indicated a positive relationship between curiosity and knowledge sharing. In particular, informal learning was found to mediate the relationship between curiosity and knowledge sharing and ebullient supervision was identified as a significant condition that strengthens the effect of curiosity on informal learning.Practical implicationsOrganizations can promote knowledge sharing by harnessing curiosity as an intrinsic motivator for employees to engage in informal learning. Moreover, the findings identified ebullient supervision as an extrinsic motivator within the work environment, suggesting its potential to enhance the impact of curiosity on knowledge sharing.Originality/valueThis paper broadens the limited literature on ebullient leadership by revealing how it strengthens the effects of curiosity and informal learning on knowledge sharing.
The trees of occupation are flourishing: employment and substitution effects of regional economic complexity
Authors: Long Teng , Li Linmu 
Published: September 2024

PurposeCan regional economic complexity improve the employment effect, and is the employment structure also affected by heterogeneity? In order to solve these doubts, this paper plans to carry out systematic theoretical analysis and quantitative tests on these problems.Design/methodology/approachBased on the macroeconomic data of 129 countries from 1995 to 2022, this paper empirically studies the impact of economic complexity on the employment effect and its mechanism channel by building relevant models.FindingsThe results show that regional economic complexity can significantly improve the employment effect of society. At the same time, regional economic complexity has an indirect positive role in promoting employment from two aspects: accumulating fiscal surplus and increasing the working-age population. The former can stimulate employment policies by increasing the government’s tax sources, while the latter can increase production specialization and complexity by stimulating demand and increasing employment. In addition, regional economic complexity will lead to job market differentiation, making the boundary between the service sector and the labor market between industry and agriculture and between the informal employment market and the formal employment more obvious, thus triggering the substitution effect of employment.Originality/valueThe possible innovations and marginal contributions of this paper are as follows: First, there are many studies on the influencing factors of employment or unemployment, and this paper provides a new research direction for the literature on the influencing factors of employment effect by using the concept of regional economic complexity for the first time. Second, this paper broadens the research perspective of the employment effect of regional economic complexity, divides the employment substitution effect of various sectors from the perspective of industrial structure and further analyzes the employment promotion effect of regional economic complexity.