bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyberespace et attentes eschatologiques : comment les technosciences participent-elles à la croyance en une humanité spirituellement connectée ?
Authors: Calheiros Cécilia 
Published: November 2015

Dans la continuité des études analysant les phénomènes de religiosité que les nouvelles technologies suscitent (O. Krueger, D. Noble, H. Campbell), cet article propose de questionner les façons dont Internet est appréhendé comme moyen de salut. Ce média, intrinsèquement lié à l’idée d’unité spirituelle de l’humanité comme stade supérieur de l’évolution, a inspiré des innovations technologiques sous-tendues par des préoccupations eschatologiques. Elles sont liées au fonctionnement de l’esprit, aux moyens de l’augmenter par les technosciences et sont motivées par une quête d’immortalité visant, à terme, à se débarrasser de la chair en transférant l’esprit humain dans la machine. Ainsi, des logiciels prédictifs, comme le Global Consciousness Project, le WebBot Project ou Google Brain, articulant conscience globale, anticipation du futur et fin du monde sont apparus. Quel sens donner à ce phénomène de réappropriation religieuse d’Internet ? Comment passe-t-on d’un lien technologique à un lien spirituel qui transcenderait l’humanité ? Et surtout, quels liens peut-il y avoir entre des logiciels prédictifs et la volonté de décorporéiser l’humain, afin de le rendre immortel ? À partir d’une analyse des sources canoniques de la cyberculture et d’une étude des communautés adhérant aux énoncés de logiciels prédictifs, cet article analyse les usages de la croyance en la conscience globale lorsqu’elle est corrélée à la divination assistée par Internet. Il montre que le développement de ces logiciels, en se parant d’un positivisme scientifique, est révélateur d’une certaine sécularisation des discours autour de la conscience globale et nous informe du rôle des technosciences dans la fabrication d’utopies pratiquées.
Ascèse sportive et mode de vie communautaire : le quotidien de sportifs de haut niveau en athlétisme
Authors: Derycke Sylvaine 
Published: November 2015

L’enquête se déroule dans un centre sportif d’excellence, l’INSEP. Il présente de profondes similitudes avec la vie monastique ce qui permet de l’envisager comme une « utopie pratiquée ». Une forme d’ascèse apparaît comme le moyen de réalisation de cette nouvelle utopie. Elle est envisagée comme le cadre à partir duquel se nouent et se dénouent les relations entre les personnes. La démarche consiste à comprendre ces connivences entre le milieu sportif et la sphère religieuse afin d’envisager la puissance implicite d’un héritage judéo-chrétien réactivé par des logiques contemporaines, et ainsi estimer la juste mesure du potentiel de renouvellement et de déplacement de productions croyantes.
De l’hypothèse d’une analogie entre « direction spirituelle » et cure psychanalytique
Authors: Botton Léo 
Published: November 2015

Cet article a été présenté lors d’une journée d’études doctorales à l’initiative du CEIFR et du CARE intitulée « Sacrés liens ! » ayant eu lieu le 21 mai 2013 à l’ÉHESS. Cette journée d’étude, problématisée autour de la notion de Lien et pariant sur son efficacité heuristique dans le cadre large et interdisciplinaire des sciences sociales des religions, a permis dans le cadre de sa quatrième session consacrée à « l’ascèce et les pratiques de soi : individu et liens sacrés » de réinterroger l’hypothèse audacieuse formulée, mais jamais développée, par Michel de Certeau d’une analogie entre pratique des Exercices spirituels et cure psychanalytique.Il a pour objectif de mettre en lumière la spécificité de la triangulation du lien entre directeur, exercitant et Dieu dans cette pratique de soi si singulière que constitue les Exercices spirituels d’Ignace de Loyola, pratique trouvant ses racines dans le xvie siècle espagnol et se voyant dispensée depuis maintenant plus de cinq siècles à un public aussi bien régulier que laïque. Pour ce faire, je m’attacherai à analyser trois extraits du texte des Exercices spirituels, à savoir la primera annotacion, le prosupuesto et le principio y fundamento, pour mettre en relief la circulation de l’expérience au sein de cette pratique spirituelle jésuite qui pourrait alors se voir rapprochée d’une pratique de soi plus contemporaine que constitue la pratique psychanalytique.
Sacrés liens ou non-liens sacrés ? Hécate, les mortels et les lieux de passage en Grèce ancienne
Authors: Serafini Nicola 
Published: November 2015

Cette étude analyse la relation qui unit la déesse Hécate aux lieux de passage, par le biais des sources littéraires qui documentent une série de rituels pratiqués dans les carrefours. De plus, la déesse était présente dans les entrées : elle est une divinité apotropaïque, qui sauvegarde l’intérieur en le protégeant des menaces de l’extérieur. À travers l’analyse des rituels accomplis dans les lieux de passage en honneur de la déesse Hécate, on explore les relations existant entre les mortels, cette divinité, et les non-lieux, en démontrant que les pratiques exécutées pour Hécate dans les non-lieux ne créaient pas de « liens sacrés » proprement dits, mais plutôt instauraient de subtils non-liens entre les mortels et la divinité, « en les liant sans les lier », pour ainsi dire.
Bidirectional Counterregulation of Human Lung Mast Cell and Airway Smooth Muscle β2 Adrenoceptors
Authors: Lewis Rebecca J. , Chachi Latifa , Newby Chris , Amrani Yassine , Bradding Peter 
Published: November 2015

Abstract
Human lung mast cells (HLMCs) play a central role in asthma pathogenesis through their relocation to the airway smooth muscle (ASM) bundles. β2 adrenoceptor (β2-AR)-agonists are used to relieve bronchoconstriction in asthma, but may reduce asthma control, particularly when used as monotherapy. We hypothesized that HLMC and human ASM cell (HASMC) responsiveness to β2-AR agonists would be attenuated when HLMCs are in contact with HASMCs. Cells were cultured in the presence of the short-acting β2-agonist albuterol, and the long-acting β2-agonists formoterol and olodaterol. Constitutive and FcεRI-dependent HLMC histamine release, HASMC contraction, and β2-AR phosphorylation at Tyr350 were assessed. Constitutive HLMC histamine release was increased in HLMC–HASMC coculture and this was enhanced by β2-AR agonists. Inhibition of FcεRI-dependent HLMC mediator release by β2-agonists was greatly reduced in HLMC–HASMC coculture. These effects were reversed by neutralization of stem cell factor (SCF) or cell adhesion molecule 1 (CADM1). β2-AR agonists did not prevent HASMC contraction when HLMCs were present, but this was reversed by fluticasone. β2-AR phosphorylation at Tyr350 occurred within 5 min in both HLMCs and HASMCs when the cells were cocultured, and was inhibited by neutralizing SCF or CADM1. HLMC interactions with HASMCs via CADM1 and Kit inhibit the potentially beneficial effects of β2-AR agonists on these cells via phosphorylation of the β2-AR. These results may explain the potentially adverse effects of β2-ARs agonists when used for asthma therapy. Targeting SCF and CADM1 may enhance β2-AR efficacy, particularly in corticosteroid-resistant patients.
Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development
Authors: Song Yinghui , Kumar Vivek , Wei Hua-Xing , Qiu Ju , Stanley Pamela 
Published: November 2015

Abstract
Lunatic, Manic, and Radical Fringe (LFNG, MFNG, and RFNG) are N-acetylglucosaminyltransferases that modify Notch receptors and regulate Notch signaling. Loss of LFNG affects thymic T cell development, and LFNG and MFNG are required for marginal zone (MZ) B cell development. However, roles for MFNG and RFNG in T cell development, RFNG in B cell development, or Fringes in T and B cell activation are not identified. In this study, we show that Lfng/Mfng/Rfng triple knockout (Fng tKO) mice exhibited reduced binding of DLL4 Notch ligand to CD4/CD8 double-negative (DN) T cell progenitors, and reduced expression of NOTCH1 targets Deltex1 and CD25. Fng tKO mice had reduced frequencies of DN1/cKit+ and DN2 T cell progenitors and CD4+CD8+ double-positive (DP) T cell precursors, but increased frequencies of CD4+ and CD8+ single-positive T cells in the thymus. In spleen, Fng tKO mice had reduced frequencies of CD4+, CD8+, central memory T cells and MZ B cells, and an increased frequency of effector memory T cells, neutrophils, follicular, and MZ P B cells. The Fng tKO phenotype was cell-autonomous and largely rescued in mice expressing one allele of a single Fng gene. Stimulation of Fng tKO splenocytes with anti-CD3/CD28 beads or LPS gave reduced proliferation compared with controls, and the generation of activated T cells by Concanavalin A or L-PHA was also reduced in Fng tKO mice. Therefore, each Fringe contributes to T and B cell development, and Fringe is required for optimal in vitro stimulation of T and B cells.
The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer
Authors: Fonteneau Jean Francois , Brilot Fabienne , Münz Christian , Gannagé Monique 
Published: November 2015

Abstract
NY-ESO-1–specific CD4+ T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II molecules for direct CD4+ T cell recognition of melanoma cells. We could rule out proteasome and autophagy-dependent endogenous Ag processing for MHC class II presentation. In contrast, intercellular Ag transfer, followed by classical MHC class II Ag processing via endocytosis, sensitized neighboring melanoma cells for CD4+ T cell recognition. However, macroautophagy targeting of NY-ESO-1 enhanced MHC class II presentation. Therefore, both elevated NY-ESO-1 release and macroautophagy targeting could improve melanoma cell recognition by CD4+ T cells and should be explored during immunotherapy of melanoma.
CD137 Agonist Therapy Can Reprogram Regulatory T Cells into Cytotoxic CD4+ T Cells with Antitumor Activity
Authors: Akhmetzyanova Ilseyar , Zelinskyy Gennadiy , Littwitz-Salomon Elisabeth , Malyshkina Anna , Dietze Kirsten K. , Streeck Hendrik , Brandau Sven , Dittmer Ulf 
Published: November 2015

Abstract
Recent successes in immune therapeutic strategies aimed to improve control over tumor growth have sparked hope that long-lived control of cancer through stimulation of the immune system can be possible. However, the underlying immunological mechanisms that are induced by immunotherapeutic strategies are not well understood. In this study, we used the highly immunogenic Friend virus–induced FBL-3 tumor as a model to study the mechanisms of immunological tumor control by CD4+ T cells in the course of CD137 (4-1BB) agonist immunotherapy in the absence of a CD8 T cell response. We demonstrate that treatment with a CD137 agonist resulted in complete FBL-3 tumor regression in CD8+ T cell–deficient mice. CD137 signaling enhanced the production of proinflammatory cytokines and cytotoxic molecules in tumor-specific CD4+ T cells. Interestingly, a subset of CD4+Foxp3+ regulatory T cells was reprogrammed to eliminate immunogenic virus-induced tumor cells in response to CD137 agonist treatment. These cells expressed markers characteristic for Th cells (CD154) and produced the cytokine TNF-α or the T-box transcriptional factor Eomesodermin and granzyme B without loss of Foxp3 expression. Foxp3 Eomes double-positive CD4+ T cells were capable of eliminating immunogenic virus-induced tumor cells in vivo. Thus, our data show that tumor-induced Foxp3+CD4+ T cells can be reprogrammed into cytotoxic effector cells upon therapeutic costimulatory signaling and restore antitumor immunity.
Cutting Edge: Nonobese Diabetic Mice Deficient in Chromogranin A Are Protected from Autoimmune Diabetes
Authors: Baker Rocky L. , Bradley Brenda , Wiles Timothy A. , Lindsay Robin S. , Barbour Gene , Delong Thomas , Friedman Rachel S. , Haskins Kathryn 
Published: November 2015

Abstract
T cells reactive to β cell Ags are critical players in the development of autoimmune type 1 diabetes. Using a panel of diabetogenic CD4 T cell clones derived from the NOD mouse, we recently identified the β cell secretory granule protein, chromogranin A (ChgA), as a new autoantigen in type 1 diabetes. CD4 T cells reactive to ChgA are pathogenic and rapidly transfer diabetes into young NOD recipients. We report in this article that NOD.ChgA−/− mice do not develop diabetes and show little evidence of autoimmunity in the pancreatic islets. Using tetramer analysis, we demonstrate that ChgA-reactive T cells are present in these mice but remain naive. In contrast, in NOD.ChgA+/+ mice, a majority of the ChgA-reactive T cells are Ag experienced. Our results suggest that the presence of ChgA and subsequent activation of ChgA-reactive T cells are essential for the initiation and development of autoimmune diabetes in NOD mice.
Annihilators and Power Values of Generalized Skew Derivations on Lie Ideals
Authors: De Filippis Vincenzo 
Published: November 2015

AbstractLet R be a prime ring of characteristic diòerent from 2, let Qrbe its right Martindale quotient ring, and let C be its extended centroid. Suppose that F is a generalized skew derivation of R, L a non-central Lie ideal ofand n, s ≥ 1 fixed integers. Iffor all u > L, then either R b Mz(C), the ring of 2 × 2 matrices over C, or m = 0 and there exists b ∊ Qrsuch that F(x) = bx, for any x ∊ R, with ab = 0.
On a Theorem of Bers, with Applications to the Study of Automorphism Groups of Domains
Authors: Krantz Steven 
Published: November 2015

AbstractWe study and generalize a classical theoremof L. Bers that classifies domains up to biholomorphic equivalence in terms of the algebras of holomorphic functions on those domains. Then we develop applications of these results to the study of domains with noncompact automorphism group
Solving Two Point Boundary Value Problems for Ordinary Differential Equations Using Exponential Finite Difference Method
Authors: Pandey Pramod K. 
Published: November 2015

In this article, a new exponential finite difference scheme for the numerical solution of two point boundary value problems with Dirichlet's boundary conditions is proposed. The scheme is based on an exponential approximation of the Taylor expansion for the discretized derivative .The convergence of the scheme discussed under appropriate condition .The theoretical and numerical results show that this new scheme is efficient and at least fourth order accurate.
Ideally slowly oscillating sequences
Authors: Hazarika Bipan 
Published: November 2015

An ideal $I$ is a family of subsets of positive integers $\mathbb{N}$ which is closed under taking finite unions and subsets of its elements. In this paper, we introduce the notion of ideally slowly oscillating sequences, which is lying between ideal convergent and ideal quasi-Cauchy sequences, and study on ideally slowly oscillating continuous functions, and ideally slowly oscillating compactness.
De shockschadevordering in het strafproces
Authors: Engelhard E.S. , Hebly M.R. , van der Zalm I. 
Published: November 2015

De shockschadevordering in het strafproces
Naasten en nabestaanden van slachtoffers van ernstige misdrijven kunnen, indien zij door de confrontatie met de schokkende gebeurtenis psychische schade lijden, zich met hun vordering tot vergoeding van shockschade voegen in het strafproces. Hoe en in welke mate worden shockschadevorderingen in het strafproces inhoudelijk behandeld, gegeven het feit dat deze vorderingen snel een onevenredige belasting van het strafproces kunnen opleveren? Welke invloed en betekenis heeft de verruiming van het voegingscriterium per 1 januari 2011 hierin? Ter beantwoording van deze vragen hebben de auteurs uitvoerig jurisprudentieonderzoek uitgevoerd naar het ‘lot’ van shockschadevorderingen in het strafproces.
Drieluikherstelbemiddeling bij seksueel misbruik, een symbiose van erkenning en financiële genoegdoening
Authors: Klijn L.P.M. 
Published: November 2015

Drieluikherstelbemiddeling bij seksueel misbruik, een symbiose van erkenning en financiële genoegdoening
Uit de contacten met slachtoffers van seksueel misbruik binnen kerkelijk verband werd duidelijk dat zij andere behoeften hadden dan enkel schadevergoeding. Met name omdat in het verleden het misbruik was ontkend of was genegeerd, bleek vooral erkenning belangrijk. Hiervoor is het nodig dat partijen tot elkaar worden gebracht. Enkel toekennen van schadevergoeding via een schadevergoedingsprocedure is daarvoor niet een passende remedie, want die brengt partijen eerder tegenover elkaar dan tot elkaar. Samen met slachtoffers is gezocht naar een weg waarbij erkenning en schadevergoeding zo konden worden gebundeld dat het een niet ten koste van het ander ging. Dat leidde tot de (door)ontwikkeling van de drieluikherstelbemiddeling. Daarover gaat dit artikel.
The Role of Exosomes and its Cargos in Drug Resistance of Cancer
Authors: Yujie Xie  , Liwu Fu  
Published: November 2015

Chemotherapy is one of the main therapies in cancer and plays an important role in controlling tumor progression, which can offer a longer overall survival (OS) for patients. But as the accumulation of drugs used in vivo, cancer cells develop drug resistance, even multi-drug resistance (MDR), that can cause failure of the whole therapy. The similar phenomenon can be observed in vitro. There are several mechanisms of drug resistance such as drug efflux, mediated by extracellular vesicles. Exosomes, a subset of extracellular vesicles (EVs), can be secreted by many types of cells and transfer proteins, lipids, and miRNA/mRNA/DNAs between cells in vitro and in vivo. Particularly cancer cells secrete more exosomes than healthy cells and resistance cells secrete more exosomes than sensitive cells. Exosomes have function of intercellular communication and molecular transfer, both associated with tumor growth, invasion, metastasis, angiogenesis, and drug resistance. In this paper, we will review the current knowledge regarding the emerging roles of exosomes and its cargo in drug resistance.
Adjusting HIV prevalence estimates for non‐participation: an application to demographic surveillance
Authors: McGovern Mark E. , Marra Giampiero , Radice Rosalba , Canning David , Newell Marie‐Louise , Bärnighausen Till 
Published: November 2015

IntroductionHIV testing is a cornerstone of efforts to combat the HIV epidemic, and testing conducted as part of surveillance provides invaluable data on the spread of infection and the effectiveness of campaigns to reduce the transmission of HIV. However, participation in HIV testing can be low, and if respondents systematically select not to be tested because they know or suspect they are HIV positive (and fear disclosure), standard approaches to deal with missing data will fail to remove selection bias. We implemented Heckman‐type selection models, which can be used to adjust for missing data that are not missing at random, and established the extent of selection bias in a population‐based HIV survey in an HIV hyperendemic community in rural South Africa.MethodsWe used data from a population‐based HIV survey carried out in 2009 in rural KwaZulu‐Natal, South Africa. In this survey, 5565 women (35%) and 2567 men (27%) provided blood for an HIV test. We accounted for missing data using interviewer identity as a selection variable which predicted consent to HIV testing but was unlikely to be independently associated with HIV status. Our approach involved using this selection variable to examine the HIV status of residents who would ordinarily refuse to test, except that they were allocated a persuasive interviewer. Our copula model allows for flexibility when modelling the dependence structure between HIV survey participation and HIV status.ResultsFor women, our selection model generated an HIV prevalence estimate of 33% (95% CI 27–40) for all people eligible to consent to HIV testing in the survey. This estimate is higher than the estimate of 24% generated when only information from respondents who participated in testing is used in the analysis, and the estimate of 27% when imputation analysis is used to predict missing data on HIV status. For men, we found an HIV prevalence of 25% (95% CI 15–35) using the selection model, compared to 16% among those who participated in testing, and 18% estimated with imputation. We provide new confidence intervals that correct for the fact that the relationship between testing and HIV status is unknown and requires estimation.ConclusionsWe confirm the feasibility and value of adopting selection models to account for missing data in population‐based HIV surveys and surveillance systems. Elements of survey design, such as interviewer identity, present the opportunity to adopt this approach in routine applications. Where non‐participation is high, true confidence intervals are much wider than those generated by standard approaches to dealing with missing data suggest.
Origin of activated combustion in steady-state premixed burner flame with superposition of dielectric barrier discharge
Authors: Zaima Kazunori , Akashi Haruaki , Sasaki Koichi 
Published: November 2015

Abstract
The objective of this work is to understand the mechanism of plasma-assisted combustion in a steady-state premixed burner flame. We examined the spatiotemporal variation of the density of atomic oxygen in a premixed burner flame with the superposition of dielectric barrier discharge (DBD). We also measured the spatiotemporal variations of the optical emission intensities of Ar and OH. The experimental results reveal that atomic oxygen produced in the preheating zone by electron impact plays a key role in the activation of combustion reactions. This understanding is consistent with that described in our previous paper indicating that the production of “cold OH(A2Σ+)” via CHO + O → OH(A2Σ+) + CO has the sensitive response to the pulsed current of DBD [K. Zaima and K. Sasaki, Jpn. J. Appl. Phys. 53, 110309 (2014)].
Influence of Na2SiO3 addition on surface microstructure and cavitation damage characteristics for plasma electrolytic oxidation of Al–Mg alloy
Authors: Lee Jung-Hyung , Son Chang-Ryeon , Kim Seong-Jong 
Published: November 2015

Abstract
Recently, plasma electrolytic oxidation (PEO) has emerged as a promising surface modification technique to improve surface properties of Al alloys. In this study, PEO coating process for Al–Mg alloy was conducted with two different electrolyte solutions under the same electrical parameters: one was potassium hydroxide (KOH) aqueous solution, and the other involved potassium hydroxide aqueous solution with sodium silicate (Na2SiO3). The surface morphology was observed with scanning electron microscope (SEM) and elemental compositions were identified with energy dispersive spectroscopy (EDS) analysis. The chemical structures of PEO coatings were identified by X-ray diffraction analysis. Cavitation experiment was performed using ultrasonic vibratory cavitation erosion testing apparatus. Cavitation damage of PEO coatings was characterized using SEM and three-dimensional (3D) microscope. The result indicated that the surface of Al–Mg alloy were successfully modified having complete different surface morphologies by changing electrolyte composition. It was found that the surface morphology had a great influence on the cavitation damage behavior of PEO coating.