bluuebunny/crossref_metadata_2025_split huggingface dataset:
El contrato de seguro y los contratos de la actividad financiera: Coberturas y tendencias del seguro global bancario
Authors: Narváez Bonnet Jorge Eduardo 
Published: December 2016

<p>Este artículo corresponde a la ponencia presentada por el autor el XXVIII Congreso de la Asociación Colombiana de Seguros –ACOLDESE- celebrado en la ciudad de Medellín en octubre de 2015.</p><p>Se analizan los principales desarrollos en materia de pólizas globales bancarias en las últimas décadas, si bien las pólizas que se utilizan en el mercado colombiano, provienen del Reino Unido, las cuales no han sufrido cambio alguno, la forma americana No. 24 que sirvió de base a las pólizas inglesas, evidentemente ha sufrido distintos ajustes y alteraciones, particularmente, en el amparo de infidelidad de empleados.</p><p>El análisis también comprende diversos tópicos, como son: la configuración del descubrimiento según los parámetros de la jurisprudencia americana; la supuesta abusividad de las cláusulas de infidelidad de empleados y de limitación de descubrimiento en estas pólizas; la extensión del deber de mitigar el daño.</p><p>Finalmente, el autor realiza un breve recuento de los desarrollos más recientes de las coberturas de responsabilidad profesional bancaria, de fraudes por sistemas computarizados y de los amparos denominados “cyber risks” y “cyber liability”.</p>
Draft Genome Sequence of the Yeast Saccharomyces cerevisiae GUJ105 From Gujarat, India
Authors: Badapanda Chandan , Detroja Rajesh , Rathore Ankita 
Published: December 2016

ABSTRACT

Here, we report the draft genome sequence of
Saccharomyces cerevisiae
strain GUJ105, isolated clinically. The size of the genome is approximately 11.5 Mb and contains 5,447 protein-coding genes.
Whole-Genome Sequence of a Suid Herpesvirus-1 Strain Isolated from the Brain of a Hunting Dog in Italy
Authors: Pizzurro Federica , Mangone Iolanda , Zaccaria Guendalina , De Luca Eliana , Malatesta Daniela , Innocenti Marco , Carmine Irene , Cito Francesca , Marcacci Maurilia , Di Sabatino Daria , Lorusso Alessio 
Published: December 2016

ABSTRACT

Suid herpesvirus-1 (SHV-1), a DNA virus of the family
Herpesviridae
, causes a severe and fatal disease in a wide range of mammals. Here, we report the whole-genome sequence of an SHV-1 isolated in Italy in 2014 from the brain of a hunting dog that suffered from an acute and severe disease.
Complete Genome Sequence of the Barley Pathogen Xanthomonas translucens pv. translucens DSM 18974
T
(ATCC 19319
T
)
Authors: Jaenicke Sebastian , Bunk Boyke , Wibberg Daniel , Spröer Cathrin , Hersemann Lena , Blom Jochen , Winkler Anika , Schatschneider Sarah , Albaum Stefan P. , Kölliker Roland , Goesmann Alexander , Pühler Alfred , Overmann Jörg , Vorhölter Frank-Jörg 
Published: December 2016

ABSTRACT

We report here the complete 4.7-Mb genome sequence of
Xanthomonas translucens
pv. translucens DSM 18974
T
, which causes black chaff disease on barley (
Hordeum vulgare
). Genome data of this
X. translucens
type strain will improve our understanding of this bacterial species.
Whole-Genome Sequencing Applied to the Molecular Epidemiology of Shiga Toxin-Producing Escherichia coli O157:H7 in Argentina
Authors: Carbonari Claudia Carolina , Fittipaldi Nahuel , Teatero Sarah , Athey Taryn B. T. , Pianciola Luis , Masana Marcelo , Melano Roberto G. , Rivas Marta , Chinen Isabel 
Published: December 2016

ABSTRACT

Shiga toxin-producing
Escherichia coli
strains are worldwide associated with sporadic human infections and outbreaks. In this work, we report the availability of high-quality draft whole-genome sequences for 19 O157:H7 strains isolated in Argentina.
Draft Genome Sequence of a Multiresistant Bovine Isolate of Staphylococcus lentus from Tanzania
Authors: Seni Jeremiah , Mshana Stephen E. , Msigwa Felician , Matee Mecky , Mazigo Humphrey , Parkhill Julian , Holmes Mark A. , Paterson Gavin K. 
Published: December 2016

ABSTRACT

We report here the draft genome sequence of a
Staphylococcus lentus
isolate, 050AP, collected in Tanzania from a swab of healthy bovine perineum. The draft genome sequence contained 2.72 Mbp and 2,750 coding sequences with a G+C content of 31.7%.
Protection against Streptococcus pneumoniae Invasive Pathogenesis by a Protein-Based Vaccine Is Achieved by Suppression of Nasopharyngeal Bacterial Density during Influenza A Virus Coinfection
Authors: Khan M. Nadeem , Xu Qingfu , Pichichero Michael E. 
Published: November 2016

ABSTRACT

An increase in
Streptococcus pneumoniae
nasopharynx (NP) colonization density during a viral coinfection initiates pathogenesis. To mimic natural
S. pneumoniae
pathogenesis, we commensally colonized the NPs of adult C57BL/6 mice with
S. pneumoniae
serotype (ST) 6A or 8 and then coinfected them with mouse-adapted H1N1 influenza A virus (PR/8/34).
S. pneumoniae
established effective commensal colonization, and influenza virus coinfection caused
S. pneumoniae
NP density to increase, resulting in bacteremia and mortality. We then studied histidine triad protein D (PhtD), an
S. pneumoniae
adhesin vaccine candidate, for its ability to prevent invasive
S. pneumoniae
disease in adult and infant mice. In adult mice, the efficacy of PhtD vaccination was compared with that of PCV13. Vaccination with PCV13 led to a greater reduction of
S. pneumoniae
NP density (>2.5 log units) than PhtD vaccination (∼1-log-unit reduction). However, no significant difference was observed with regard to the prevention of
S. pneumoniae
bacteremia, and there was no difference in mortality. Depletion of CD4
+
T cells in PhtD-vaccinated adult mice, but not PCV13-vaccinated mice, caused a loss of vaccine-induced protection. In infant mice, passive transfer of antisera or CD4
+
T cells from PhtD-vaccinated adult mice led to a nonsignificant reduction in NP colonization density, whereas passive transfer of antisera and CD4
+
T cells was needed to cause a significant reduction in NP colonization density. For the first time, these data show an outcome with regard to prevention of invasive
S. pneumoniae
pathogenesis with a protein vaccine similar to that which occurs with a glycoconjugate vaccine despite a less robust reduction in NP bacterial density.
Ethnic differences in the prevalence of knee pain among adults of a community in a cross-sectional study
Authors: Chia Yook Chin , Beh Hooi Chin , Ng Chirk Jenn , Teng Cheong Lieng , Hanafi Nik Sherina , Choo Wan Yuen , Ching Siew Mooi 
Published: December 2016

ObjectiveTo determine the prevalence of knee pain among 3 major ethnic groups in Malaysia. By identifying high-risk groups, preventive measures can be targeted at these populations.Design and settingA cross-sectional survey was carried out in rural and urban areas in a state in Malaysia. Secondary schools were randomly selected and used as sampling units.ParticipantsAdults aged ≥18 years old were invited to answer a self-administered questionnaire on pain experienced over the previous 6 months. Out of 9300 questionnaires distributed, 5206 were returned and 150 participants who did not fall into the 3 ethnic groups were excluded, yielding a total of 5056 questionnaires for analysis. 58.2% (n=2926) were women. 50% (n=2512) were Malays, 41.4% (n=2079) were Chinese and 8.6% (n=434) were Indians.Results21.1% (n=1069) had knee pain during the previous 6 months. More Indians (31.8%) experienced knee pain compared with Malays (24.3%) and Chinese (15%) (p<0.001). The odds of Indian women reporting knee pain was twofold higher compared with Malay women. There was a rising trend in the prevalence of knee pain with increasing age (p<0.001). The association between age and knee pain appeared to be stronger in women than men. 68.1% of Indians used analgesia for knee pain while 75.4% of Malays and 52.1% of Chinese did so (p<0.001). The most common analgesic used for knee pain across all groups was topical medicated oil (43.7%).ConclusionsThe prevalence of knee pain in adults was more common in Indian women and older women age groups and Chinese men had the lowest prevalence of knee pain. Further studies should investigate the reasons for these differences.
Defining adolescent common mental disorders using electronic primary care data: a comparison with outcomes measured using the CIS-R
Authors: Cornish Rosie P , John Ann , Boyd Andy , Tilling Kate , Macleod John 
Published: December 2016

ObjectiveTo compare the prevalence of common mental disorders (CMDs) derived from data held in primary care records with that measured using the revised Clinical Interview Schedule (CIS-R) in order to assess the potential robustness of findings based only on routinely collected data.Design and settingComparison study using linkage between the Avon Longitudinal Study of Parents and Children (ALSPAC) and electronic primary care records.ParticipantsWe studied 1562 adolescents who had completed the CIS-R in ALSPAC at age 17–18 years and had linkage established to their primary care records.Outcome measuresOutcome measures from ALSPAC were whether or not an individual met International Classification of Diseases-10 criteria for a diagnosis of (1) a CMD or, specifically, (2) depression. Lists of Read codes corresponding to diagnoses, symptoms and treatments were used to create 12 definitions of CMD and depression alone using the primary care data. We calculated sensitivities and specificities of these, using CIS-R definitions as the reference standard.ResultsSensitivities ranged from 5.2% to 24.3% for depression and from 3.8% to 19.2% for CMD. The specificities of all definitions were above 98% for depression and above 96% for CMD.For both outcomes, the definition that included current diagnosis, treatment or symptoms identified the highest proportion of CIS-R cases.ConclusionsMost individuals meeting case definitions for CMD based on primary care data also met CIS-R case definitions. Conversely many individuals identified as cases using the CIS-R had no evidence of CMD in their clinical records. This suggests that clinical databases are likely to yield underestimates of the burden of CMD in the population. However, clinical records appear to yield valid diagnoses which may be useful for studying risk factors and consequences of CMD. The greatest epidemiological value may be obtained when information is available from survey and clinical records.
Postoperative prophylaxis in Crohn's disease after intestinal resection: a retrospective analysis
Authors: O'Connor Anthony , Hamlin Peter J , Taylor Jennifer , Selinger Christian , Scott Nigel , Ford Alexander C 
Published: December 2016

IntroductionUp to 80% of patients with Crohn's disease (CD) may require surgery at some point in their lives, and it is estimated that as many as 40% may require several surgeries. It has been suggested that prophylactic medication decreases the rate of clinical and endoscopic recurrence following intestinal resection. This study aims to describe real-world clinical outcomes observed from a pragmatic, individualised strategy in postoperative CD.MethodsAll patients undergoing intestinal resection for CD between 2009 and 2013 were identified. The endpoint of the study, treatment success, was defined as glucocorticosteroid-free, resection-free survival, at the last point of follow-up, without requiring an escalation or change of therapy during this time. Clinical information was extracted from chart reviews, endoscopy and radiology reports, and from prescribing databases. Patients were followed from the date of surgery, and the last point of follow-up was 31 January 2015.Results149 patients were analysed. Median duration of follow-up was 32 months (range 1–69 months). 101 patients received postoperative prophylactic therapy, and 48 did not. In 77 (51.7%) patients, thiopurines were used as first-line therapy, with treatment success occurring in 32 (41.6%) with a median follow-up of 25 months. 11 patients (7.4%) received anti-tumour necrosis factor (TNF)-α monotherapy, with treatment success occurring in 5 patients (45.5%) with a median follow-up of 35 months. 13 (8.7%) patients received first-line combination therapy, with 11 (84.6%) patients achieving treatment success with a median follow-up of 21 months.ConclusionsIn our study, combination therapy with anti-TNF-α and immunomodulator therapy was well tolerated, efficacious (efficacy appeared durable for patients with postoperative CD) and superior to monotherapy with either thiopurines or anti-TNF-α drugs. Several limitations notwithstanding, our data suggest that there may be merit in the use of combination therapy in carefully selected postoperative patients whose care has been individualised via a multidisciplinary team meeting format. Prospective, controlled studies are therefore required to further assess the efficacy and safety of combination therapy for postoperative prophylaxis in CD.
Effects of the etonogestrel contraceptive implant (Implanon®) on bone metabolism during lactation: a prospective study
Authors: Iltemir Duvan Candan , Onaran Yuksel , Aktepe Keskin Esra , Yüce Ebru , Yanık Burcu , Kafali Hasan , Ozturk Turhan Nilgun 
Published: December 2016

AimTo evaluate the effects of the etonogestrel contraceptive implant (Implanon®) on bone metabolism in lactating women using markers for bone formation and resorption.Study designThis single-centre, prospective cohort study was conducted in Turgut Ozal University Medical Faculty Obstetrics and Gynecology Department with healthy lactating women aged between 24 and 38 years to compare the effect on bone metabolism of 6 months’ use of either the implant or a non-hormonal contraceptive method. The study group (n=25) used an implant and the control group (n=25) used a non-hormonal contraceptive intrauterine device inserted 40 days’ postpartum. Bone metabolism differences at the time of insertion and after 6 months were assessed quantitatively by biochemical analysis of serum and urine samples.ResultsAt baseline, serum levels of bone metabolism parameters were similar for the two groups. In the implant group, serum alkaline phosphatase (ALP) levels decreased (p=0.004) and total protein levels increased (p=0.045) at 6 months. In the control group, serum levels of bone metabolism parameters did not change at 6 months compared to baseline. However, serum levels of phosphorus (p=0.013) and ALP (p=0.003) decreased at 6 months compared to baseline.ConclusionSix months’ postpartum use of Implanon was found to have no deleterious impact on bone turnover in healthy lactating women.
Unique cytokine and chemokine responses to exertional heat stroke in mice
Authors: King Michelle A. , Leon Lisa R. , Morse Deborah A. , Clanton Thomas L. 
Published: December 2016

In heat stroke, cytokines are believed to play important roles in multiorgan dysfunction and recovery of damaged tissue. The time course of the cytokine response is well defined in passive heat stroke (PHS), but little is known about exertional heat stroke (EHS). In this study we used a recently developed mouse EHS model to measure the responses of circulating cytokines/chemokines and cytokine gene expression in muscle. A very rapid increase in circulating IL-6 was observed at maximum core temperature (Tc,max) that peaked at 0.5 h of recovery and disappeared by 3 h. IL-10 was not elevated at any time. This contrasts with PHS where both IL-6 and IL-10 peak at 3 h of recovery. Keratinocyte chemoattractant (KC), granulocyte-colony-stimulating factor (G-CSF), macrophage inflammatory protein (MIP)-2, MIP-1β, and monocyte chemoattractive factor-1 also demonstrated near peak responses at 0.5 h. Only G-CSF and KC remained elevated at 3 h. Muscle mRNA for innate immune cytokines (IL-6, IL-10, IL-1β, but not TNF-α) were greatly increased in diaphragm and soleus compared with similar measurements in PHS. We hypothesized that these altered cytokine responses in EHS may be due to a lower Tc,maxachieved in EHS or a lower overall heat load. However, when these variables were controlled for, they could not account for the differences between EHS and PHS. We conclude that moderate exercise, superimposed on heat exposure, alters the pattern of circulating cytokine and chemokine production and muscle cytokine expression in EHS. This response may comprise an endocrine reflex to exercise in heat that initiates survival pathways and early onset tissue repair mechanisms.NEW & NOTEWORTHY Immune modulators called cytokines are released following extreme hyperthermia leading to heat stroke. It is not known whether exercise in hyperthermia, leading to EHS, influences this response. Using a mouse model of EHS, we discovered a rapid accumulation of interleukin-6 and other cytokines involved in immune cell trafficking. This response may comprise a protective mechanism for early induction of cell survival and tissue repair pathways needed for recovery from thermal injury.
Patent Foramen Ovale With Atrial Septal Aneurysm Is Strongly Associated With Migraine With Aura: A Large Observational Study
Authors: Snijder Roel J. R. , Luermans Justin G. L. M. , de Heij Albert H. , Thijs Vincent , Schonewille Wouter J. , Van De Bruaene Alexander , Swaans Martin J. , Budts Werner I. H. L. , Post Martijn C. 
Published: December 2016

Background

A patent foramen ovale (
PFO
) with atrial septal aneurysm (
ASA
) has been identified as a risk factor for cryptogenic stroke. Patients with migraine with aura (
MA
) appear to be at risk for silent brain infarction, which might be related to the presence of a
PFO
. However, the association between
MA
and
PFO
with
ASA
has never been reported. We examined this association in a large observational study.

Methods and Results

Patients (>18 years) who underwent an agitated saline transesophageal echocardiography (c
TEE
) at our outpatient clinics within a timeframe of 4 years were eligible to be included. Before c
TEE
they received a validated headache questionnaire. Two neurologists diagnosed migraine with or without aura according to the International Headache Criteria. A total of 889 patients (mean age 56.4±14.3 years, 41.7% women) were included. A
PFO
was present in 23.2%, an isolated
ASA
in 2.7%, and a
PFO
with
ASA
in 6.9%. The occurrence of migraine was 18.9%; the occurrence of
MA
was 8.1%. The prevalence of
PFO
with
ASA
was significantly higher in patients with
MA
compared to patients without migraine (18.1% vs 6.1%;
OR
3.72, 95%
CI
1.86‐7.44,
P
<0.001). However, a
PFO
without
ASA
was not significantly associated with
MA
(
OR
1.50, 95%
CI
0.79‐2.82,
P
=0.21). Interestingly, a
PFO
with
ASA
was strongly associated with
MA
(
OR
2.71, 95%
CI
1.23‐5.95,
P
=0.01).

Conclusion

In this large observational study,
PFO
with
ASA
was significantly associated with
MA
only.
PFO
closure studies should focus on this specific intra‐atrial anomaly.
Prediction of Blood–Brain Barrier Disruption and Intracerebral Hemorrhagic Infarction Using Arterial Spin-Labeling Magnetic Resonance Imaging
Authors: Niibo Takeya , Ohta Hajime , Miyata Shirou , Ikushima Ichiro , Yonenaga Kazuchika , Takeshima Hideo 
Published: December 2016

Background and Purpose—
Arterial spin-labeling magnetic resonance imaging is sensitive for detecting hyperemic lesions (HLs) in patients with acute ischemic stroke. We evaluated whether HLs could predict blood–brain barrier (BBB) disruption and hemorrhagic transformation (HT) in acute ischemic stroke patients.

Methods—
In a retrospective study, arterial spin-labeling was performed within 6 hours of symptom onset before revascularization treatment in 25 patients with anterior circulation large vessel occlusion on baseline magnetic resonance angiography. All patients underwent angiographic procedures intended for endovascular therapy and a noncontrast computed tomography scan immediately after treatment. BBB disruption was defined as a hyperdense lesion present on the posttreatment computed tomography scan. A subacute magnetic resonance imaging or computed tomography scan was performed during the subacute phase to assess HTs. The relationship between HLs and BBB disruption and HT was examined using the Alberta Stroke Program Early Computed Tomography Score locations in the symptomatic hemispheres.

Results—

A HL was defined as a region where CBF
relative
≥1.4 (CBF
relative
=CBF
HL
/CBF
contralateral
). HLs, BBB disruption, and HT were found in 9, 15, and 15 patients, respectively. Compared with the patients without HLs, the patients with HLs had a higher incidence of both BBB disruption (100% versus 37.5%;
P
=0.003) and HT (100% versus 37.5%;
P
=0.003). Based on the Alberta Stroke Program Early Computed Tomography Score locations, 21 regions of interests displayed HLs. Compared with the regions of interests without HLs, the regions of interests with HLs had a higher incidence of both BBB disruption (42.8% versus 3.9%;
P
<0.001) and HT (85.7% versus 7.8%;
P
<0.001).

Conclusions—
HLs detected on pretreatment arterial spin-labeling maps may enable the prediction and localization of subsequent BBB disruption and HT.
Infarct Pattern and Collateral Status in Adult Moyamoya Disease
Authors: Kim Dong Yeop , Son Jeong Pyo , Yeon Je Young , Kim Gyeong-Moon , Kim Jong-Soo , Hong Seung-Chyul , Bang Oh Young 
Published: December 2016

Background and Purpose—
Moyamoya disease (MMD) is a unique cerebrovascular disease characterized by the progressive stenosis of large intracranial arteries and a hazy network of basal collaterals, called moyamoya vessels. Although hemodynamic studies have been applied in MMD patients, the mechanisms of stroke in MMD are still unclear. The present study evaluated the infarct pattern and collateral status using multimodal magnetic resonance imaging in MMD patients.

Methods—
Adult MMD patients with acute ischemic stroke were prospectively recruited, and infarct pattern on diffusion-weighted imaging was evaluated. A collateral flow map, derived from magnetic resonance perfusion–weighted imaging data, was generated through automatic postprocessing, and collateral status was assigned into 3 grades. Transcranial Doppler monitoring was performed to detect microembolic signals in selected patients.

Results—
A total of 67 hemispheres (31 patients with bilateral and 5 patients with unilateral MMD) were analyzed. Most patients (83.7%) showed embolic pattern and rarely deep (9.3%) or hemodynamic infarct pattern (7.0%) on diffusion-weighted imaging. Most cases (86%) showed good collateral status, and few patients with acute infarcts of embolic pattern showed poor collateral status (n=7). One third (31.6%) of patients who underwent transcranial Doppler monitoring showed microembolic signals.

Conclusions—
In the studied population of adult MMD patients, embolic phenomenon played an important role in ischemic stroke. Therapeutic strategies against thromboembolism, as well as collateral enhancing strategies targeting improvement of hemodynamic status or increased washout of emboli, are warranted.