bluuebunny/crossref_metadata_2025_split huggingface dataset:
Double-strand breaks are not the main cause of spontaneous sister chromatid exchange in wild-type yeast cells
Authors: Claussin Clémence , Porubský David , Spierings Diana C.J. , Halsema Nancy , Rentas Stefan , Guryev Victor , Lansdorp Peter M. , Chang Michael 
Published: July 2017

SummaryHomologous recombination involving sister chromatids is the most accurate, and thus most frequently used, form of recombination-mediated DNA repair. Despite its importance, sister chromatid recombination is not easily studied because it does not result in a change in DNA sequence, making recombination between sister chromatids difficult to detect. We have previously developed a novel DNA template strand sequencing technique, called Strand-seq, that can be used to map sister chromatid exchange (SCE) events genome-wide in single cells. An increase in the rate of SCE is an indicator of elevated recombination activity and of genome instability, which is a hallmark of cancer. In this study, we have adapted Strand-seq to detect SCE in the yeastSaccharomyces cerevisiae. Contrary to what is commonly thought, we find that most spontaneous SCE events are not due to the repair of DNA double-strand breaks.
ShinyGPAS: Interactive genomic prediction accuracy simulator based on deterministic formulas
Authors: Morota Gota 
Published: July 2017

AbstractBackgroundDeterministic formulas highlight the relationships among prediction accuracy and potential factors influencing prediction accuracy prior to performing computationally intensive cross-validation. Visualizing such deterministic formulas in an interactive manner may lead to a better understanding of how genetic factors control prediction accuracy.ResultsThe software to simulate deterministic formulas for genomic prediction accuracy was implemented in R and encapsulated as a web-based Shiny application. ShinyGPAS (Shiny Genomic Prediction Accuracy Simulator) simulates various deterministic formulas and delivers dynamic scatter plots of prediction accuracy vs. genetic factors impacting prediction accuracy, while requiring only mouse navigation in a web browser. ShinyGPAS is available at:https://chikudaisei.shinyapps.io/shinygpas/.ConclusionShinyGPAS is a shiny-based interactive genomic prediction accuracy simulator using deterministic formulas. It can be used for interactively exploring potential factors influencing prediction accuracy in genome-enabled prediction, simulating achievable prediction accuracy prior to genotyping individuals, or supporting in-class teaching. ShinyGPAS is open source software and it is hosted online as a freely available web-based resource with an intuitive graphical user interface.
Neural network models of the tactile system develop first-order units with spatially complex receptive fields
Authors: Zhao Charlie W. , Daley Mark J. , Pruszynski J. Andrew 
Published: July 2017

AbstractFirst-order tactile neurons have spatially complex receptive fields. Here we use machine learning tools to show that such complexity arises for a wide range of training sets and network architectures, and benefits network performance, especially on more difficult tasks and in the presence of noise. Our work suggests that spatially complex receptive fields are normatively good given the biological constraints of the tactile periphery.
How do South Korean female executives’ definitions of career success differ from those of male executives?
Authors: Cho Yonjoo , Park Jiwon , Han Soo Jeoung “Crystal” , Ju Boreum , You Jieun , Ju Ahreum , Park Chan Kyun , Park Hye Young 
Published: July 2017

PurposeThe purpose of this study was to compare South Korean female executives’ definitions of career success with those of male executives, identify their career development strategies for success and provide implications for research and practice. Two research questions guiding our inquiry included: How do female executives’ definitions of career success differ from those of male executives? What career development strategies do male and female executives use for career success?Design/methodology/approachA basic qualitative research design was used and semi-structured interviews were conducted with 15 male executives and 15 female executives in diverse corporations by using an interview protocol of 13 questions regarding participants’ background, definitions of career success and final thoughts. To analyze the interview data, we used both NVivo 11 and a manual coding method.FindingsGender differences were detected in the participants’ definitions of career success and success factors. As previous studies indicated, male and female executives had different perspectives on career success: men tended to define career success more objectively than women. Many male executives, through experiencing transforming changes in their careers, began to appreciate work–life balance and personal happiness from success. Gender differences were also detected in their career development challenges, meanings of mentors and networking activities. While work stress surfaced as a challenge that men faced, experiencing the token status in the gendered workplace was a major challenge for female participants.Research limitations/implicationsIn this study, three research agendas are presented, needing further investigation on career success, women’s token status and comparative analyses.Practical implicationsThree implications for practice have been provided, including organizational support, government’s role and HRD’s role.Originality/valueGender differences in this study were not as distinctive as previous literature has indicated. Some male executives valued more subjective career success than others, while a few female executives spoke of more objective definitions than others. These subtle differences could be captured through in-depth interviews. By hearing the participants’ stories, both objective and subjective definitions of success, for both genders, could be observed, which might not have been possible in quantitative research. In addition, the study findings reflect the nature of a uniquely Korean context. The participants worked in a Confucian and military culture, which operates in hierarchical structures and the command and control system, coupled with a heightened camaraderie spirit in the workplace.
The role of non-governmental organizations in vaccine development and delivery
Authors: Walton Jason 
Published: July 2017

Purpose
The purpose of this paper is to define the role non-governmental organizations (NGOs) play across the vaccine development and delivery spectrum within the vaccine enterprise. As demonstrated in this paper, NGOs can play a critical role in prioritizing and accelerating the development and introduction of new vaccines against diseases that disproportionally burden children, women, and communities in the poorest countries around the world.

Design/methodology/approach
The author has used case studies from decades of work by PATH, an international NGO, to help develop and implement vaccines, to illustrate the roles of NGOs can play during each of the stages along the development and delivery spectrum.

Findings
There are four key considerations that can help determine the ability of a given vaccine to be introduced and scaled within a health system: accessibility, affordability, acceptability, and availability. As more vaccine candidates are identified and move along the development and delivery pathway, there will be increased demand for NGOs to continue playing a pivotal role to address these considerations.

Originality/value
This paper aims to highlight a few of the lessons learned from PATH's four decades of experience in the hope they will contribute and be applied to the evolving environment of vaccine enterprise.
Parenting as politics: social identity theory and vaccine hesitant communities
Authors: Attwell Katie , Smith David T. 
Published: July 2017

Purpose
The purpose of this paper is to develop a theoretical framework for understanding the identity politics associated with parental hesitancy and refusal of vaccines for their children (“vaccine hesitancy or refusal” or “VHR”). Understanding these identity politics helps policymakers to craft appropriate communication interventions that do not make the problem worse.

Design/methodology/approach
Social identity theory is a way of understanding how group identities develop around the lifestyle practices that often include refusal to vaccinate, and how this group identity is accentuated by conflict with the pro-vaccinating societal mainstream. This paper critically appraises existing studies of VHR to explore this groupness across many different contexts.

Findings
Groupness is evident across many different contexts. There are also key group characteristics: preference for natural birth and breastfeeding, nature as a concept and use of complementary and alternative medicine.

Research limitations/implications
The paper is speculative and theoretical, using existing sources. Future studies will need to demonstrate empirically with new data. However, this theoretical approach sets up a new research agenda.

Social implications
These findings can help governments and policymakers minimise social conflict that risks further polarising vaccine conversations and wedging parents on the fence.

Originality/value
This paper argues that the decision to vaccinate or not is an inherently social one, not a matter of pure individual rationality. This is a novel approach to engaging with what is often characterised and studied as an individual decision.
The long way to professional recognition: project management in Italy
Authors: Sabini Luca , Muzio Daniel 
Published: July 2017

Purpose
The professionalization of project management (PM) profession has developed differently according to the different environments in which it has been introduced. The purpose of this paper is to examine an example of this professional project (Italy) with this research question: “what have been the professionalization strategies of PM professional associations within Italian field?”

Design/methodology/approach
The authors develop a qualitative case study made up of semi-structured interviews and archival data.

Findings
The analysis demonstrates how PM in Italy has embarked on a clear upward trajectory in terms of its occupational size, economic significance and institutional development. However, the development of PM in Italy considerably lags behind Anglo-Saxon countries. The authors also identify three main strategies through which this professionalization project is being accomplished (see Section 5). These are corporate engagement, expanding membership and institutional recognition.

Research limitations/implications
The study reviews the professionalization of PM in Italy. This is not a comparative study, but rather highlights Italian PM professionalization. Moreover, the authors expect significant findings could be reached with a comparable research across different national contexts.

Originality/value
This work constitutes the first detailed and comprehensive study in the field of PM within the Italian context.
Defining project partnering
Authors: Børve Sjur , Rolstadås Asbjørn , Andersen Bjorn , Aarseth Wenche 
Published: July 2017

Purpose
Due to observed problems in real-life projects stemming from the lack of a unified definition, the purpose of this paper is to formulate a new definition of project partnering (PP) through documenting the specific characteristics researchers attribute to this approach.

Design/methodology/approach
PP definition phrases extracted from a literature review were sorted into a basic framework of who, what, how, when and where. In a web-based survey, a group of experts marked the phrases from the literature review as being specific, generic, or irrelevant to PP. The expert group comprised highly ranked and experienced PP researchers. Based on the survey results, a new definition was formulated. The new definition specifies the participants, the objectives and the knowledge, skills, tools and techniques applied to pursue the objectives in PP. A verification survey of the expert group gave a 78-96 per cent combined approve and support score for each element of the new definition.

Findings
PP and a partnering project are defined by a framework encompassing three basic dimensions: participants, objectives, knowledge, skills, tools and techniques applied to pursue the objectives. The new definition is: “project partnering is a relationship strategy whereby a project owner integrates contractors and other major contributors into the project”. Through commitment to mutual project objectives, collaborative problem solving and a joint governance structure, partners pursue collaborative relationships, trust and improved performance. The new definition indicates that PP neither varies with early contractor involvement nor gain and pain share, but varies with the degree of mutual project objectives, collaborative problem solving and joint governance structure.

Originality/value
PP is a complex concept with no widely accepted definition. The basic framework applied to the formulation of the definition in this project can also be applied to define and implement a partnering project and to define and distinguish between other relationship-based procurement forms.
Innovation in alliancing for improved delivery of road infrastructure projects
Authors: Che Ibrahim Che Khairil Izam , Costello Seosamh B. , Wilkinson Suzanne , Walker Derek 
Published: July 2017

Purpose
The purpose of this paper is to explore innovation in alliance contracting in the New Zealand construction industry in terms of features (i.e. development process, risk/reward framework and leadership structure) that could influence successful project outcomes.

Design/methodology/approach
This study employed a qualitative research methodology. Three alliancing projects have been identified as the cases. By using interviews with the project’s owner and non-owner participants and related project documentation, the relevant features in the three examined cases were identified and compared.

Findings
The findings revealed differences in the reasoning why a particular alliance approach was implemented, how the alliance selection process was conducted and what kind of leadership structure was adopted. Interestingly, a number of unique and innovative practices to alliancing were also highlighted, notably the innovative agreements, innovative governance structure and innovative functional teams that influence the synergistically creative solutions to suit the clients’ needs.

Practical implications
The innovative practices identified in this study have brought the alliancing concept to a new level of practice in the industry. The findings provide a basis and a platform for discussion, both nationally and internationally, to gain greater understanding in managing different alliance contracting towards breakthrough outcomes.

Originality/value
This study extends the alliancing procurement literature, in particular, but also provides significant insights into innovative advancements to the collaborative procurement approaches.
Investigating supplier-induced complexity in supply chains
Authors: Gerschberger Markus , Manuj Ila , Freinberger Patrick 
Published: July 2017

Purpose
The purpose of this paper is to understand and measure empirically the objective and perceived dimensions of supplier-induced complexity in supply chains.

Design/methodology/approach
An equal-weight, complementary mixed-method approach is used to investigate supplier-induced complexity and understand its impact on outcomes. Initial qualitative research and extant literature review allowed the identification of supplier characteristics that add complexity to supply chains and development of four research hypotheses. Subsequently, quantitative analysis was used for testing the hypotheses.

Findings
The results suggest that supplier-induced complexity is related to adverse outcomes, and both perceived and objective dimensions of complexity are valuable in understanding and measuring supplier-induced complexity.

Research limitations/implications
This study employs a mixed-method approach to establish and test relationships among perceived and objective supplier-induced complexity, and their outcomes. The unit of analysis is the first-tier suppliers of one farm equipment manufacturing firm. This limits the generalizability of the results to similar industrial manufacturing firms.

Practical implications
This paper presents an approach to identify suppliers that add the highest levels of complexity to a supply chain and, thus, require closer monitoring. Specific supplier characteristics are identified for individual suppliers. Developing specific complexity-related measures helps better identify critical suppliers compared to traditional approaches (e.g. ABC analysis).

Originality/value
This paper contributes to supply chain management literature by comprehensively exploring supplier-induced complexity, incorporating the often-ignored perceived complexity dimension, and providing a managerially useful framework.
A bibliometric analysis of reverse logistics research (1992-2015) and opportunities for future research
Authors: Wang Jian-Jun , Chen Haozhe , Rogers Dale S. , Ellram Lisa M. , Grawe Scott J. 
Published: July 2017

PurposeInterest in reverse logistics (RL) as a critical component of supply chain management (SCM) is gaining more traction with both practitioners and academics. Because of RL’s growing strategic importance, it is imperative to conduct a timely and comprehensive literature review and to identify associated opportunities for future research. The paper aims to discuss these issues.Design/methodology/approachIn this paper, the researchers conduct an extensive bibliometric analysis of published academic articles on RL for the period of 1992-2015. Specifically, the CiteSpace software is utilized to conduct document co-citation analysis and burst detection analysis on 912 selected RL articles and their 22,642 references.FindingsThis research identifies the most influential RL research publications/citations in each of the five periods and their research contribution. Using co-citation analysis, the authors are able to identify and illustrate major research themes, knowledge groups, and future research opportunities in the RL field.Originality/valueIn contrast to existing literature review studies in the logistics field, the study uses impact factor as a key article selection criterion. The influential articles identified in this process well represent the core literature and RL body of knowledge and have important implications for future research.
The Physical Internet – review, analysis and future research agenda
Authors: Sternberg Henrik , Norrman Andreas 
Published: July 2017

Purpose
The Physical Internet (PI) is an emerging concept that applies the Digital Internet as a design metaphor for the development of sustainable, interoperable and collaborative freight transport. With the aim of aiding researchers and policy makers in their future efforts to develop efficient logistics systems, the purpose of this paper is to present a review of the existing literature on the PI, to critically discuss the concept and to outline a research agenda.

Design/methodology/approach
The literature review investigates scientific papers, project reports, specifications and other publications related to PI. In total, 46 publications were finally analyzed. The approach used in this paper is technology adoption by firms. The authors examine the PI based on four factors: organizational readiness (technological blueprints), external pressure (promised effects), perceived benefits (business model) and adoption.

Findings
A growing number of strategies, blueprints and specifications have been developed for PI, yet there are no currently developed models that illustrate how the move from the entrenched logistics business models to the PI could ensue. There is a lack of understanding of the business models needed that can involve critical actors and promote the adoption of the PI concept.

Research limitations/implications
While using the internet as a metaphor for reimagining physical transports is certainly exciting, this review and analysis suggest that several research questions need to be addressed before further PI blueprint work is carried out.

Practical implications
The “grand challenge” of sustainability in logistics needs to be addressed and improved, but the authors’ analysis suggests that, to some extent, it is uncertain how the PI will contribute to improving sustainability, and why logistics service providers should engage in PI. Policy makers and practitioners are provided with critical issues to consider in the practical development and adoption of the concept.

Originality/value
This paper provides an outsider and technology-adoption perspective of PI research, as well as important implications for policy makers and researchers.
Pedagogical content knowledge of sustainability
Authors: Singer-Brodowski Mandy 
Published: July 2017

Purpose
This paper’s purpose is to describe students’ learning processes in a project-based and self-organized seminar on sustainability. A detailed knowledge of typical learning processes is part of a pedagogical content knowledge of sustainability and can therefore contribute to the professional development of university educators.

Design/methodology/approach
In a project-based and self-organized seminar, a case study has been conducted with the grounded theory’s methodological approach. Data were collected from student interviews, group discussions and observations of students’ planning and organization meetings.

Findings
The results of the case study show that students’ learning processes vary depending on their pre-seminar sustainability experiences. Two types have been established: sustainability newcomers and sustainability experts. Furthermore, the results indicate the importance of emotions in the involvement with sustainability.

Research limitations/implications
The significance of the case study is limited by a small number of cases. Also, the results are specific for a seminar self-organized by the students and can therefore not simply be transferred to other seminars.

Practical implications
Knowledge of specific learning processes and a possible conceptual change in sustainability classes could be an important issue in the professional development of university educators because it would increase the educators’ pedagogical content knowledge.

Originality/value
The triangulation of qualitative data mainly served the investigation of students’ perspectives and therefore the understanding of subjective preferences, experiences and learning processes in the field of higher education for sustainable development (HESD).