bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oncogenic miR-9 is a target of erlotinib in NSCLCs
Authors: Chen Xi , Zhu Lingjun , Ma Zhuo , Sun Geng , Luo Xuan , Li Min , Zhai Sulan , Li Ping , Wang Xuerong 
Published: November 2015

AbstractEGFR-targeted cancer therapy is a breakthrough in non-small cell carcinoma. miRNAs have been proved to play important roles in cancer. Currently, for the role of miRNAs in EGFR-targeted cancer therapy is unclear. In this study, first we found that erlotinib reduced the expression of miR-9. MiR-9 expression was increased in human lung cancer tissues compared with peripheral normal tissues and miR-9 promoted the growth of NSCLC cells. Overexpression of miR-9 decreased the growth inhibitory effect of erlotinib. Second, miR-9 decreased FoxO1 expression by directly inhibition of its mRNA translation. Adenovirus-mediated overexpression of FoxO1 or siRNA-mediated downregulation of FoxO1 negatively regulated cell growth. And exogenous overexpression FoxO1 reduced the pro-growth effect of miR-9. Finally, we found that erlotinib upregulated FoxO1 protein expression. Moreover, overexpression of miR-9 decreased erlotinib-induced FoxO1 expression and overexpression of FoxO1 enhanced the growth inhibitory effects of erlotinib. Additionally, we found that erlotinib downregulates miR-9 expression through suppressing the transcrption of miR-9-1 and enhanced DNA methylation maybe involved. These findings suggest that oncogenic miR-9 targeted FoxO1 to promote cell growth and downregulation of this axis was involved in erlotinib’s growth inhibitory effects. Clarifying the regulation of miRNAs by erlotinib may indicate novel strategies for enhancing EGFR-targeted cancer therapy.
Modeling the consequences of the demise and potential recovery of a keystone-species: wild rabbits and avian scavengers in Mediterranean landscapes
Authors: Cortés-Avizanda Ainara , Colomer Maria Àngels , Margalida Antoni , Ceballos Olga , Donázar José Antonio 
Published: November 2015

AbstractRestoration of demised keystone-species populations is an overriding concern in conservation biology. However, since no population is independent of its environment, progress is needed in predicting the efficacy of restoration in unstable ecological contexts. Here, by means of Population Dynamics P-system Models (PDP), we studied long-term changes in the population size of Egyptian vultures (Neophron percnopterus) inhabiting a Natural Park, northern Spain, to changes in the numbers of wild rabbits (Oryctolagus cuniculus), a keystone-species of Mediterranean ecosystems that have suffered >90% population decline after a hemorrhagic disease outbreak. Low availability of rabbit carcasses leads Egyptian vultures to extend their foraging activities to unprotected areas with higher non-natural mortality whereas growing numbers of griffon vultures (Gyps fulvus), a dominant competitor, progressively monopolize trophic resources resulting in a focal population decrease. Modeling shows that, even if keystone-species populations recover in core protected areas, the return to the original studied population size may be unfeasible, due to both the high non-natural mortality rates in humanized areas and long-term changes in the scavenger guild structure. Policy decisions aimed to restore keystone-species should rely on holistic approaches integrating the effects of spatial heterogeneity on both producer and consumer populations as well as within-guild processes.
Beta diversity determinants in Badagongshan, a subtropical forest in central China
Authors: Qiao Xiujuan , Li Qianxi , Jiang Qinghu , Lu Junmeng , Franklin Scott , Tang Zhiyao , Wang Qinggang , Zhang Jiaxin , Lu Zhijun , Bao Dachuan , Guo Yili , Liu Haibo , Xu Yaozhan , Jiang Mingxi 
Published: November 2015

AbstractNiche and neutral theories emphasize different processes contributing to the maintenance of species diversity. In this study, we calculated the local contribution to beta diversity (LCBD) of every cell, using variation partitioning in combination with spatial distance and environmental variables of the 25-ha Badagongshan plot (BDGS), to determine the contribution of environmentally-related variation versus pure spatial variation. We used topography and soil characteristics as environmental variables, distance-based Moran’s eigenvectors maps (dbMEM) to describe spatial relationships among cells and redundancy analysis (RDA) to apportion the variation in beta diversity into three components: pure environmental, spatially-structured environmental and pure spatial. Results showed LCBD values were negatively related to number of common species and positively related to number of rare species. Environment and space jointly explained ~60% of the variation in species composition; soil variables alone explained 21.6%, slightly more than the topographic variables that explained 15.7%; topography and soil together explained 27%, slightly inferior to spatial variables that explained 34%. The BDGS forest was controlled both by the spatial and environmental variables and the results were consistent across different life forms and life stages.
Neuron Image Analyzer: Automated and Accurate Extraction of Neuronal Data from Low Quality Images
Authors: Kim Kwang-Min , Son Kilho , Palmore G. Tayhas R. 
Published: November 2015

AbstractImage analysis software is an essential tool used in neuroscience and neural engineering to evaluate changes in neuronal structure following extracellular stimuli. Both manual and automated methods in current use are severely inadequate at detecting and quantifying changes in neuronal morphology when the images analyzed have a low signal-to-noise ratio (SNR). This inadequacy derives from the fact that these methods often include data from non-neuronal structures or artifacts by simply tracing pixels with high intensity. In this paper, we describe Neuron Image Analyzer (NIA), a novel algorithm that overcomes these inadequacies by employing Laplacian of Gaussian filter and graphical models (i.e., Hidden Markov Model, Fully Connected Chain Model) to specifically extract relational pixel information corresponding to neuronal structures (i.e., soma, neurite). As such, NIA that is based on vector representation is less likely to detect false signals (i.e., non-neuronal structures) or generate artifact signals (i.e., deformation of original structures) than current image analysis algorithms that are based on raster representation. We demonstrate that NIA enables precise quantification of neuronal processes (e.g., length and orientation of neurites) in low quality images with a significant increase in the accuracy of detecting neuronal changes post-stimulation.
A combination approach to treating fungal infections
Authors: Shrestha Sanjib K. , Fosso Marina Y. , Garneau-Tsodikova Sylvie 
Published: November 2015

AbstractAzoles are antifungal drugs used to treat fungal infections such as candidiasis in humans. Their extensive use has led to the emergence of drug resistance, complicating antifungal therapy for yeast infections in critically ill patients. Combination therapy has become popular in clinical practice as a potential strategy to fight resistant fungal isolates. Recently, amphiphilic tobramycin analogues, C12 and C14, were shown to display antifungal activities. Herein, the antifungal synergy of C12 and C14 with four azoles, fluconazole (FLC), itraconazole (ITC), posaconazole (POS) and voriconazole (VOR), was examined against seven Candida albicans strains. All tested strains were synergistically inhibited by C12 when combined with azoles, with the exception of C. albicans 64124 and MYA-2876 by FLC and VOR. Likewise, when combined with POS and ITC, C14 exhibited synergistic growth inhibition of all C. albicans strains, except C. albicans MYA-2876 by ITC. The combinations of FLC-C14 and VOR-C14 showed synergistic antifungal effect against three C. albicans and four C. albicans strains, respectively. Finally, synergism between C12/C14 and POS were confirmed by time-kill and disk diffusion assays. These results suggest the possibility of combining C12 or C14 with azoles to treat invasive fungal infections at lower administration doses or with a higher efficiency.
Elevated Extinction Rates as a Trigger for Diversification Rate Shifts: Early Amniotes as a Case Study
Authors: Brocklehurst Neil , Ruta Marcello , Müller Johannes , Fröbisch Jörg 
Published: November 2015

AbstractTree shape analyses are frequently used to infer the location of shifts in diversification rate within the Tree of Life. Many studies have supported a causal relationship between shifts and temporally coincident events such as the evolution of “key innovations”. However, the evidence for such relationships is circumstantial. We investigated patterns of diversification during the early evolution of Amniota from the Carboniferous to the Triassic, subjecting a new supertree to analyses of tree balance in order to infer the timing and location of diversification shifts. We investigated how uneven origination and extinction rates drive diversification shifts and use two case studies (herbivory and an aquatic lifestyle) to examine whether shifts tend to be contemporaneous with evolutionary novelties. Shifts within amniotes tend to occur during periods of elevated extinction, with mass extinctions coinciding with numerous and larger shifts. Diversification shifts occurring in clades that possess evolutionary innovations do not coincide temporally with the appearance of those innovations, but are instead deferred to periods of high extinction rate. We suggest such innovations did not cause increases in the rate of cladogenesis, but allowed clades to survive extinction events. We highlight the importance of examining general patterns of diversification before interpreting specific shifts.
Wideband radar cross‐section reduction by AMC
Authors: Esmaeli S.H. , Sedighy S.H. 
Published: November 2015

A new planar wideband chessboard structure is designed to reduce the radar cross‐section (RCS) of an object. This proposed chessboard configuration is composed of two different artificial magnetic conductor (AMC) tiles. One of these tiles is formed by saltire arrow unit cells, whereas the other one is formed by four E‐shaped ones. A 180° ± 30° phase difference between these tiles achieved by precise design of the AMC unit cells of more than 9.4–23.28 GHz (85%) reduces the RCS by more than 10 dB. The fabricated board results show very good agreement with the simulated ones, which verify the ability and capability of the proposed structure.
Inductively coupled modular battery system for electric vehicles
Authors: Kandasamy Karthik , Vilathgamuwa Don Mahinda , Madawala Udaya Kumara , Tseng King‐Jet 
Published: November 2015

This study proposes two novel modularised battery systems capable of controlling the power of each module independently, and with inductive interface for convenient battery swapping. The proposed systems aid in overcoming the limitations such as unavailability of electric vehicle (EV) due to battery pack fault and lengthy battery recharging time which largely hampers the adoption of EVs for personal transportation. The proposed systems consist of a plurality of battery modules which are wirelessly coupled to the EV through inductive power transfer technology. The proposed systems are described in detail, and models are presented to analyse their steady‐state behaviours. A design guideline for a 24 kWh 80 kW battery micro‐pack system is discussed. Performances of the proposed topologies are investigated using simulations. To demonstrate the applicability, prototype systems of 1.5 kW are implemented and tested under various operating conditions. Results convincingly indicate that the proposed systems improve the vehicle's availability under fault condition.
Simple Implant Augmentation Rhinoplasty
Authors: Nguyen Anh H. , Bartlett Erica L. , Kania Katarzyna , Bae Sang Mo 
Published: November 2015

AbstractAugmentation rhinoplasty among Asian patients is often performed to improve the height of the nasal dorsum. As the use of autogenous tissues poses certain limitations, alloplastic materials are a viable alternative with a long history of use in Asia. The superiority of one implant prosthesis over another for augmentation rhinoplasty is a matter of debate, with each material representing varying strengths and weaknesses, indications for use, and precautions to consider in nasal implant placement. An implant prosthesis should be used on a case-by-case basis. Augmentation rhinoplasty requires the consideration of specific anatomical preoperative factors, including the external nose, nasal length, nasofrontal angle, humps, and facial proportions. It is equally important to consider several operative guidelines to appropriately shape implants to minimize the occurrence of adverse effects and postoperative complications. The most common postoperative complications include infection, nasal height change, movement of implant prosthesis, and silicone implant protrusion. In addition, the surgeon should consider the current standards of Asian beauty aesthetics to better understand the patient's desired outcome.
The sparkling Universe: the coherent motions of cosmic voids
Authors: Lambas Diego García , Lares Marcelo , Ceccarelli Laura , Ruiz Andrés N. , Paz Dante J. , Maldonado Victoria E. , Luparello Heliana E. 
Published: November 2015

Abstract
We compute the bulk motions of cosmic voids, using a Λ cold dark matter numerical simulation considering the mean velocities of the dark matter inside the void itself and that of the haloes in the surrounding shell. We find coincident values of these two measures in the range ∼300–400 km s−1, not far from the expected mean peculiar velocities of groups and galaxy clusters. When analysing the distribution of the pairwise relative velocities of voids, we find a remarkable bimodal behaviour consistent with an excess of both systematically approaching and receding voids. We determine that the origin of this bimodality resides in the void large-scale environment, since once voids are classified into void-in-void (R-type) or void-in-cloud (S-type), R-types are found mutually receding away, while S-types approach each other. The magnitude of these systematic relative velocities account for more than 100 km s−1, reaching large coherence lengths of up to 200 h−1 Mpc . We have used samples of voids from the Sloan Digital Sky Survey Data Release 7 and the peculiar velocity field inferred from linear theory, finding fully consistent results with the simulation predictions. Thus, their relative motion suggests a scenario of a sparkling universe, with approaching and receding voids according to their local environment.
Pilot CBT trial for anxiety in alcohol use disorders treatment
Authors: Fielder Andrea Louise , Mikocka-Walus Antonina , McCallum Stacey , Stewart Benjamin , Alvaro Pasquale , Esterman Adrian 
Published: November 2015

Purpose
– The purpose of this paper is to test the effectiveness of a self-directed cognitive behavioural therapy (CBT) booklet allowing immediate access to treatment for anxiety during alcohol use disorder (AUD) interventions.

Design/methodology/approach
– Parallel pilot randomised controlled trial: 69 individuals in AUD treatment, continued to receive treatment alone (control: n=29) or in addition, a self-directed, four week CBT booklet to manage anxiety (intervention: n=40). Primary outcome measures were changes in state (SAnx) and trait anxiety (TAnx) at four weeks. Secondary outcome measures were changes in adaptive (ACop), maladaptive (MCop) coping and quality of life (QoL, physical (PHQoL), psychological (PSQoL), social (SQoL), environment (EQoL)) at four weeks.

Findings
– Participants had significantly higher SAnx (p
<
0.01) and TAnx (p
<
0.01) baseline scores compared to the general population. There were no statistically significant group changes in SAnx or TAnx (p
>
0.05). Control group allocation predicted improvement in ACop (p
<
0.01), MCop (p
<
0.05), PHQoL (p
<
0.01), PSQoL (p
<
0.05) and SQoL (p
<
0.01); CBT group allocation predicted improvement in EQoL (p=0.05). All effect sizes were small to moderate (Cohen’s d
<
0.50). Percentage of book completion did not determine changes in anxiety, coping or quality of life.

Originality/value
– A four week self-directed CBT booklet did not significantly reduce anxiety during AUD treatment. Larger sample sizes will determine the most suitable treatment delivery mode for this type of CBT.
Core memories in library finance
Authors: Steele Kirstin 
Published: November 2015

Purpose
– This paper aims to explore the author
'
s own personal involvement with library finance.

Design/methodology/approach
– This is a viewpoint piece.

Findings
– This piece explores the idea of core memories in relation to library finance.

Originality/value
– This is an autobiographical piece inspired by Pixar
'
s 2015 film Inside Out.
Nudges and decision making: a winning combination
Authors: Hall-Ellis Sylvia D. 
Published: November 2015

Purpose
– Evaluating a situation and circumstance to make a decision is an essential managerial skill. Experienced managers can use nudging to influence decisions that subordinate and embed the practice within the institution as a learning organization. Adopting a nudge theory perspective changes the workplace environment, so that individuals make decisions that are helpful to themselves for job satisfaction and professional growth as well as positive for the organization. Research suggests that nudging has positive results that contribute to increased productivity, higher morale and decreased expenses.

Design/methodology/approach
– This is an opinion piece.

Findings
– This is an opinion piece.

Research limitations/implications
– This is not a research article.

Practical implications
– Administrators can use the recommendations in this column.

Social implications
– Administrators can use the recommendations in this column.

Originality/value
– This is an original viewpoint.
Management innovations in a Chinese hotel company: the case of 7 Days Inn
Authors: Qin Yu , Li Bin , Yu Larry 
Published: November 2015

Purpose– This study aims to analyze management innovations developed by a homegrown Chinese hotel company aimed at sustaining its growth and reveals some unorthodox management practices in the lodging industry in China.Design/methodology/approach– A theoretical sampling process was used to choose 7 Days Inn as a single case study. Semi-structured in-depth personal interviews of 15 informants with varying responsibilities were conducted to obtain organization-specific insights. Content analysis of the transcripts was performed to analyze interview data. Secondary data and interviews of managers in competing hotels were also used to support the findings.Findings– This study identified seven major innovative management practices developed by 7 Days Inn. Most of these innovations arose from the company’s idiosyncratic collective mindset. The company created a different approach to thinking about the basic issues regarding business and management – including managerial roles, mistakes and change – that constituted the cornerstones of its management innovations.Research limitations/implications– Owing to the limitations of case method, the findings may not be generalizable to other Chinese hotel companies.Practical implications– As little is known about innovative management practices by homegrown hotel companies in China, this study sheds new light on a creative and distinctive management system in the Chinese hotel industry. Introducing management styles that differ significantly from those of Western companies will benefit both management researchers and practitioners.Originality/value– This study extends previous findings in management innovation by uncovering indigenous innovation influenced by traditional Chinese cultural values in China’s hospitality industry.
How to make your Facebook posts attractive
Authors: Su Na , Reynolds Dennis , Sun Bixuan 
Published: November 2015

Purpose
– This study aims to identify what type of post is most effective in drawing fans to like, comment on or share it, building on the premise that hotels can only benefit when “fans” – customers who “like” them – engage in discussion and interaction on Facebook.

Design/methodology/approach
– In the case of the Super 8 Hotels Facebook fan page, 14 underlying factors related to themes, media, characteristics and time are identified in a content analysis of its posts. Multilevel regression is employed in the study to test the effects of these 14 factors on the number of fans who like, comment on or share a post.

Findings
– Posts about hotel products and attributes diminish the attractiveness to the hotel brand’s Facebook page. The posts that include award and discount information, expressed in a humorous way or end with requests to like tend to be liked more often by fans. Furthermore, posts ending with a question are likely to get more comments, but these questions have a negative influence on the number of likes the post receives. In addition, posts with pictures or involving environment concerns are more likely to be shared by fans.

Practical implications
– The paper provides hotel practitioners with implementable communication tactics to increase their appeal to consumers on Facebook.

Originality/value
– The study represents a new academic area of how to communicate using social media and concludes with practical strategies for hoteliers seeking to utilize Facebook as an effective marketing tool.
Employment support to home-workers: the role of civil society
Authors: Mitra Arup , Kumar Rajnish 
Published: November 2015

Purpose
– The purpose of this paper is to examine the effectiveness of civil society in providing higher levels of employment and earnings compared to what labour contractors usually offer.

Design/methodology/approach
– Based on the primary survey data the authors have estimated econometric models to capture who is likely to join the civil society and whether joining actually improves the earnings.

Findings
– The authors observe that a civil society not necessarily is able to provide employment opportunities on a large scale nor it is able to take a lead role in multiple activities. The binomial logit model is indicative that women from large households with greater domestic burden tend to join the civil society and subsequently their earnings increase. However, the lack of work consignment forces many workers to operate through the contractors. Not necessarily the functioning of a civil society ensures optimal outcomes.

Research limitations/implications
– The survey was conducted on the members of only one civil society.

Practical implications
– For a civil society to be successful active operation and a large scale coverage are important. The government and civil society closely may have to operate in order to reap better outcomes. Otherwise like government failures civil society failures can also be rampant.

Originality/value
– A direct evaluation of civil society participation is done in comparison to those who do operate through the contractors.