bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of Gestational Diabetes Mellitus With Left Ventricular Structure and Function: The CARDIA Study
Authors: Appiah Duke , Schreiner Pamela J. , Gunderson Erica P. , Konety Suma H. , Jacobs David R. , Nwabuo Chike C. , Ebong Imo A. , Whitham Hilary K. , Goff David C. , Lima Joao A. , Ku Ivy A. , Gidding Samuel S. 
Published: January 2016

OBJECTIVE
Gestational diabetes mellitus (GDM) predicts incident cardiovascular disease (CVD). However, mechanisms linking GDM to CVD beyond intervening incident diabetes are not well understood. We examined the relation of GDM with echocardiographic parameters of left ventricular (LV) structure and function, which are important predictors of future CVD risk.

RESEARCH DESIGN AND METHODS
We studied 609 women (43% black) from the Coronary Artery Risk Development in Young Adults (CARDIA) study who delivered one or more births during follow-up and had echocardiograms in 1990–1991 (mean age 28.8 years) and 2010–2011.

RESULTS
During the 20-year follow-up, 965 births were reported, with GDM developing in 64 women (10.5%). In linear regression models adjusted for sociodemographic factors, BMI, physical activity, parity, smoking, use of oral contraceptives, alcohol intake, family history of coronary heart disease, systolic blood pressure, and lipid levels, women with GDM had impaired longitudinal peak strain (−15.0 vs. −15.7%, P = 0.025), circumferential peak strain (−14.8 vs. −15.6%, P = 0.028), lateral e′ wave velocity (11.0 vs. 11.8 cm/s, P = 0.012), and septal e′ wave velocity (8.6 vs. 9.3 cm/s, P = 0.015) in 2010–2011 and a greater 20-year increase in LV mass indexed to body surface area (14.3 vs. 6.0 g/m2, P = 0.006) compared with women with non-GDM pregnancies. Further adjustment for incident type 2 diabetes after pregnancy did not attenuate these associations.

CONCLUSIONS
Pregnancy complicated by GDM is independently associated with increased LV mass and impaired LV relaxation and systolic function. Implementation of postpartum cardiovascular health interventions in women with a history of GDM may offer an additional opportunity to reduce future CVD risk.
Health Care Transition in Young Adults With Type 1 Diabetes: Perspectives of Adult Endocrinologists in the U.S.
Authors: Garvey Katharine C. , Telo Gabriela H. , Needleman Joseph S. , Forbes Peter , Finkelstein Jonathan A. , Laffel Lori M. 
Published: January 2016

OBJECTIVE
Young adults with type 1 diabetes transitioning from pediatric to adult care are at risk for adverse outcomes. Our objective was to describe experiences, resources, and barriers reported by a national sample of adult endocrinologists receiving and caring for young adults with type 1 diabetes.

RESEARCH DESIGN AND METHODS
We fielded an electronic survey to adult endocrinologists with a valid e-mail address identified through the American Medical Association Physician Masterfile.

RESULTS
We received responses from 536 of 4,214 endocrinologists (response rate 13%); 418 surveys met the eligibility criteria. Respondents (57% male, 79% Caucasian) represented 47 states; 64% had been practicing &gt;10 years and 42% worked at an academic center. Only 36% of respondents reported often/always reviewing pediatric records and 11% reported receiving summaries for transitioning young adults with type 1 diabetes, although &gt;70% felt that these activities were important for patient care. While most respondents reported easy access to diabetes educators (94%) and dietitians (95%), fewer (42%) reported access to mental health professionals, especially in nonacademic settings. Controlling for practice setting and experience, endocrinologists without easy access to mental health professionals were more likely to report barriers to diabetes management for young adults with depression (odds ratio [OR] 5.3; 95% CI 3.4, 8.2), substance abuse (OR 3.5; 95% CI 2.2, 5.6), and eating disorders (OR 2.5; 95% CI 1.6, 3.8).

CONCLUSIONS
Our findings underscore the need for enhanced information transfer between pediatric and adult providers and increased mental health referral access for young adults with diabetes post-transition.
Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial
Authors: Fedorko Ludwik , Bowen James M. , Jones Wilhelmine , Oreopoulos George , Goeree Ron , Hopkins Robert B. , O’Reilly Daria J. 
Published: January 2016

OBJECTIVE
Hyperbaric oxygen therapy (HBOT) is used for the treatment of chronic diabetic foot ulcers (DFUs). The controlled evidence for the efficacy of this treatment is limited. The goal of this study was to assess the efficacy of HBOT in reducing the need for major amputation and improving wound healing in patients with diabetes and chronic DFUs.

RESEARCH DESIGN AND METHODS
Patients with diabetes and foot lesions (Wagner grade 2–4) of at least 4 weeks' duration participated in this study. In addition to comprehensive wound care, participants were randomly assigned to receive 30 daily sessions of 90 min of HBOT (breathing oxygen at 244 kPa) or sham (breathing air at 125 kPa). Patients, physicians, and researchers were blinded to group assignment. At 12 weeks postrandomization, the primary outcome was freedom from meeting the criteria for amputation as assessed by a vascular surgeon. Secondary outcomes were measures of wound healing.

RESULTS
One hundred fifty-seven patients were assessed for eligibility, with 107 randomly assigned and 103 available for end point adjudication. Criteria for major amputation were met in 13 of 54 patients in the sham group and 11 of 49 in the HBOT group (odds ratio 0.91 [95% CI 0.37, 2.28], P = 0.846). Twelve (22%) patients in the sham group and 10 (20%) in the HBOT group were healed (0.90 [0.35, 2.31], P = 0.823). All other indices of wound healing were also not statistically significantly different between groups.

CONCLUSIONS
HBOT does not offer an additional advantage to comprehensive wound care in reducing the indication for amputation or facilitating wound healing in patients with chronic DFUs.
Day-and-Night Hybrid Closed-Loop Insulin Delivery in Adolescents With Type 1 Diabetes: A Free-Living, Randomized Clinical Trial
Authors: Tauschmann Martin , Allen Janet M. , Wilinska Malgorzata E. , Thabit Hood , Stewart Zoë , Cheng Peiyao , Kollman Craig , Acerini Carlo L. , Dunger David B. , Hovorka Roman 
Published: January 2016

OBJECTIVE
To evaluate feasibility, safety, and efficacy of day-and-night hybrid closed-loop insulin delivery in adolescents with type 1 diabetes under free-living conditions without remote monitoring or supervision.

RESEARCH DESIGN AND METHODS
In an open-label, randomized, free-living, crossover study design, 12 adolescents receiving insulin pump therapy (mean [±SD] age 15.4 ± 2.6 years; HbA1c 8.3 ± 0.9%; duration of diabetes 8.2 ± 3.4 years) underwent two 7-day periods of sensor-augmented insulin pump therapy or hybrid closed-loop insulin delivery without supervision or remote monitoring. During the closed-loop insulin delivery, a model predictive algorithm automatically directed insulin delivery between meals and overnight; prandial boluses were administered by participants using a bolus calculator.

RESULTS
The proportion of time when the sensor glucose level was in the target range (3.9–10 mmol/L) was increased during closed-loop insulin delivery compared with sensor-augmented pump therapy (72 vs. 53%, P &lt; 0.001; primary end point), the mean glucose concentration was lowered (8.7 vs. 10.1 mmol/L, P = 0.028), and the time spent above the target level was reduced (P = 0.005) without changing the total daily insulin amount (P = 0.55). The time spent in the hypoglycemic range was low and comparable between interventions.

CONCLUSIONS
Unsupervised day-and-night hybrid closed-loop insulin delivery at home is feasible and safe in young people with type 1 diabetes. Compared with sensor-augmented insulin pump therapy, closed-loop insulin delivery may improve glucose control without increasing the risk of hypoglycemia in adolescents with suboptimally controlled type 1 diabetes.
Effects of post-curing on the thermo-mechanical behavior and the chemical structure of highly filled phenolic molding compounds
Authors: Scheffler Thomas , Englich Sascha , Heyne Ulrich , Gehde Michael 
Published: January 2016

AbstractDue to their excellent thermomechanical properties, as well as their good media resistance, phenolic molding compounds are outstanding materials for high temperature applications, such as components for the engine compartment. An additional post-curing process, after injection molding, shifts the glass transition temperature towards high temperatures up to 300 °C. The objective of this work is to analyze the influence of the post-curing process on the chemical structure of the material. This structure is responsible for the mechanical and thermal properties of the material. Therefore tensile test bars were molded with a highly filled phenolic molding compound and different post-curing cycles under different atmospheres were done. The tensile properties and the glass transition temperatures (TMA) were measured. To get detailed information of the chemical structure ATR-FTIR and NMR analyses were done. The mechanical properties decreased up to 25 % with higher post-curing temperature (under air atmosphere) although the glass transition temperatures (TMA) and the grades of curing (NMR) increased. Furthermore, in the ATR-FTIR measurements, oxidation products were detected on the surface of the sample which were post-cured under air atmosphere. In comparison, no oxidation products could be detected on the samples post-cured under nitrogen atmosphere and the mechanical properties just decreased about 4 %. Oxidation processes could be provided by post-curing under nitrogen atmosphere which led to higher mechanical properties, in connection with a high grade of cure and a higher glass transition temperature in comparison with post-curing under air atmosphere.
Effect of drawing with shear on structure and properties of low-carbon steel
Authors: Pashinskaya Elena , Zavdoveev Anatoly , Mironov Sergey , Varyukhin Victor , Maksakova Anna 
Published: January 2016

AbstractThe feasibility of drawing with shear of low-carbon steel for wire production was studied. The new approach was shown to be more effective in producing of homogeneous microstructure with refined grain size, reduced porosity and increased mechanical strength. These effects were attributed to a specific “twist” character of material flow.
Isolation and characterization of 28 microsatellite loci for a Korean endemic, Lespedeza maritima (Fabaceae)
Authors: Jin Dong‐Pil , Cho Won‐Bum , Choi In‐Su , Choi Byoung‐Hee 
Published: January 2016

Premise of the study:We developed microsatellite primers for Lespedeza maritima (Fabaceae), a Korean endemic shrub, and conducted cross‐amplifications for closely related species.Methods and Results:We produced 28 polymorphic microsatellite markers through reference mapping of 300‐bp paired‐end reads obtained from Illumina MiSeq data. For 47 individual plants from two populations, the total alleles numbered two to 13, and observed and expected heterozygosities ranged from 0.067 to 0.867 and from 0.064 to 0.848, respectively. Most of these markers were well amplified in closely related species.Conclusions:In future research, the microsatellite markers described here will help reveal the taxonomic entity of this species.
Preservation of iridescent colours in Phorinia Robineau-Desvoidy, 1830 (Diptera: Tachinidae)
Authors: Braet Yves , Downes Stephen , Simonis Priscilla 
Published: January 2016

Iridescent blue-green colours are exhibited by various organisms including several taxa in the Tachinidae (Diptera) with notable examples within the Afrotropical members of the genus Phorinia Robineau-Desvoidy, 1830. The vivid colouration observed in life quickly fades to a dull golden-yellow when a specimen is dried. Although well known, no published explanation has been given for this phenomenon.
We illustrate the mechanism associated with this colour change. We also test and propose technical alternatives to retain the living colours in dried specimens.
Une anomalie normale de l’État de droit
Authors: Salle Grégory 
Published: January 2016

Dans le cadre d’un dossier sur les « réformes de l’enfermement », cette contribution étudie la détention provisoire en République fédérale d’Allemagne depuis l’après-guerre à partir des critiques incessantes dont ce régime est chroniquement la cible. Les excès comme les lacunes de cette pratique font en effet l’objet de griefs récurrents et consensuels, pouvant aller jusqu’à mettre en cause la qualité de l’État de droit elle-même. Ils alimentent en retour d’incessants appels à la « réforme » de ce qui fait figure d’exception abusivement normalisée depuis au moins l’ordonnance d’exécution faisant autorité en la matière, dont la version initiale date de 1953, sans grand changement en pratique. Comment expliquer la persistance d’un fonctionnement quasi unanimement décrié comme anormal, voire scandaleux ? Cet article propose un début de réponse en présentant d’abord les motifs structurants des critiques adressées depuis lors à la détention avant jugement, en distinguant le vide juridique, la démesure quantitative, la discrimination judiciaire, l’aberration carcérale et l’instrumentalisation sociopolitique. Sur cette base, il s’efforce ensuite de rendre compte de la baisse sensible du nombre de détenus prévenus depuis vingt ans, qui peut apparaître comme un signe d’intégration de la critique, en replaçant cette tendance quantitative dans une recomposition plus générale des moyens de la coercition étatique.
Genetically-based resistance of balsam fir (Pinaceae) to damage from the balsam twig aphid (Hemiptera: Aphididae)
Authors: Edwards Sara , Jesson Linley K. , Quiring Dan , Weng Yuhui , Johns Rob , Park Yill Sung 
Published: January 2016

AbstractWe evaluated the effect of tree genotype on the resistance of balsam fir,Abies balsamea(Linnaeus) Miller (Pinaceae), to damage from the balsam twig aphid,Mindarus abietinusKoch (Hemiptera: Aphididae), by visually assessing aphid damage in clonal seed orchards located in New Brunswick and Nova Scotia, Canada, during four consecutive years. Estimates of clone mean heritability were moderate, suggesting that heritability of resistance is influenced by genetic factors. In New Brunswick, positive phenotypic and genetic correlations of clone-mean damage among years indicate that clones rank similarly each year. Our results suggest that selectively breeding for increased resistance could result in genetic gains.
Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood
Authors: Quách Tâm D. , Rodríguez-Zhurbenko Nely , Hopkins Thomas J. , Guo Xiaoti , Hernández Ana María , Li Wentian , Rothstein Thomas L. 
Published: January 2016

Abstract
Human Ab-secreting cell (ASC) populations in circulation are not well studied. In addition to B-1 (CD20+CD27+CD38lo/intCD43+) cell and conventional plasmablast (PB) (CD20-CD27hiCD38hi) cell populations, in this study, we identified a novel B cell population termed 20+38hi B cells (CD20+CD27hiCD38hi) that spontaneously secretes Ab. At steady-state, 20+38hi B cells are distinct from PBs on the basis of CD20 expression, amount of Ab production, frequency of mutation, and diversity of BCR repertoire. However, cytokine treatment of 20+38hi B cells induces loss of CD20 and acquisition of CD138, suggesting that 20+38hi B cells are precursors to PBs or pre-PBs. We then evaluated similarities and differences among CD20+CD27+CD38lo/intCD43+ B-1 cells, CD20+CD27hiCD38hi 20+38hi B cells, CD20−CD27hiCD38hi PBs, and CD20+CD27+CD38lo/intCD43− memory B cells. We found that B-1 cells differ from 20+38hi B cells and PBs in a number of ways, including Ag expression, morphological appearance, transcriptional profiling, Ab skewing, Ab repertoire, and secretory response to stimulation. In terms of gene expression, B-1 cells align more closely with memory B cells than with 20+38hi B cells or PBs, but differ in that memory B cells do not express Ab secretion-related genes. We found that B-1 cell Abs use Vh4-34, which is often associated with autoreactivity, 3- to 6-fold more often than other B cell populations. Along with selective production of IgM anti–phosphoryl choline, these data suggest that human B-1 cells might be preferentially selected for autoreactivity/natural specificity. In summary, our results indicate that human healthy adult peripheral blood at steady-state consists of three distinct ASC populations.
Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone
Authors: St. Louis Derek , Romero Roberto , Plazyo Olesya , Arenas-Hernandez Marcia , Panaitescu Bogdan , Xu Yi , Milovic Tatjana , Xu Zhonghui , Bhatti Gaurav , Mi Qing-Sheng , Drewlo Sascha , Tarca Adi L. , Hassan Sonia S. , Gomez-Lopez Nardhy 
Published: January 2016

Abstract
Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality worldwide. Although intra-amniotic infection is a recognized cause of spontaneous preterm labor, the noninfection-related etiologies are poorly understood. In this article, we demonstrated that the expansion of activated CD1d-restricted invariant NKT (iNKT) cells in the third trimester by administration of α-galactosylceramide (α-GalCer) induced late PTB and neonatal mortality. In vivo imaging revealed that fetuses from mice that underwent α-GalCer–induced late PTB had bradycardia and died shortly after delivery. Yet, administration of α-GalCer in the second trimester did not cause pregnancy loss. Peroxisome proliferator–activated receptor (PPAR)γ activation, through rosiglitazone treatment, reduced the rate of α-GalCer–induced late PTB and improved neonatal survival. Administration of α-GalCer in the third trimester suppressed PPARγ activation, as shown by the downregulation of Fabp4 and Fatp4 in myometrial and decidual tissues, respectively; this suppression was rescued by rosiglitazone treatment. Administration of α-GalCer in the third trimester induced an increase in the activation of conventional CD4+ T cells in myometrial tissues and the infiltration of activated macrophages, neutrophils, and mature dendritic cells to myometrial and/or decidual tissues. All of these effects were blunted after rosiglitazone treatment. Administration of α-GalCer also upregulated the expression of inflammatory genes at the maternal–fetal interface and systemically, and rosiglitazone treatment partially attenuated these responses. Finally, an increased infiltration of activated iNKT-like cells in human decidual tissues is associated with noninfection-related preterm labor/birth. Collectively, these results demonstrate that iNKT cell activation in vivo leads to late PTB by initiating innate and adaptive immune responses and suggest that the PPARγ pathway has potential as a target for prevention of this syndrome.
Madinat Al-Zahra. La Ciudad Brillante La investigación como difusión
Authors: Montilla Torres Irene , Vallejo Triano Antonio 
Published: January 2016

<p>As Madinat al-Zahra grows with the opening of its new Museum, it required a huge increase within the diffusion resources used until that precise moment in order to explain the caliphal city. One of the chosen options was to create an audiovisual presentation which, on the base of computer graphics and compiling the results of the research developed on the last decades in the Archaeological Site, shall offer a scientifically rigorous explanation and, at the same time, easy to understand for a diverse audience. This tool so becomes in a powerful instrument in order to transfer scientific knowledge to society.</p>
The soundscape of the ceremonies for the beatification of St Teresa of Ávila in the Crown of Aragon, 1614
Authors: Knighton Tess , Mazuela-Anguita Ascensión 
Published: January 2016

Abstract: The beatification of Saint Teresa of Ávila in October 1614 gave rise to widespread celebrations in many of the cities and towns of the Iberian Peninsula. Printed relaciones describing these celebrations, despite their limitations ?in terms of political agenda, propaganda, rivalry and literary style— can nevertheless provide information about musical experience and can help to recreate the ephemeral soundscapes of these events. This article will focus on the ceremonies held in the Crown of Aragon, especially Saragossa and Barcelona, taking into consideration the typology of different musics?heraldic, divine and festive?and factors such as the moment in time, function, dynamic, urban spaces and blurring of boundaries, public (listeners), musical resources and performance practice, repertories and genres, signifiers and associations for listeners, and impact. Keywords: urban musicology; Teresa of Jesus; beatification festivities; musical experience; Crown of Aragon Resum: Paraules clau:
Insertion of interlayers in efficient polymer-based organic solar cells for control of phase separation
Authors: Taima Tetsuya , Tanaka Jun , Kuwabara Takayuki , Takahashi Kohshin 
Published: January 2016

Abstract
To improve the solar cell performance of polymer-based organic solar cells, the control of phase separation in the bulk heterojunction (BHJ) layer is important. In the case of a thienothiophene–benzodithiophene-based polymer (PTB7)-based solar cell, 1,8-diiodoctane (DIO) is added into the chlorobenzene solvent. However, it is well known that DIO addition causes degradation in long-term operation. Here, we try to improve the performance of the PTB7-based BHJ solar cell by controlling the phase separation in the BHJ layer through the insertion of an inorganic semiconducting copper iodide (CuI) interlayer between the BHJ layer and indium tin oxide. The power conversion efficiency of the PTB7-based solar cell is improved from 3.5 to 3.9% upon inserting the CuI interlayer without DIO addition.
Observation of ambipolar switching in a silver nanoparticle single-electron transistor with multiple molecular floating gates
Authors: Yamamoto Makoto , Shinohara Shuhei , Tamada Kaoru , Ishii Hisao , Noguchi Yutaka 
Published: January 2016

Abstract
Ambipolar switching behavior was observed in a silver nanoparticle (AgNP)-based single-electron transistor (SET) with tetra-tert-butyl copper phthalocyanine (ttbCuPc) as a molecular floating gate. Depending on the wavelength of the incident light, the stability diagram shifted to the negative and positive directions along the gate voltage axis. These results were explained by the photoinduced charging of ttbCuPc molecules in the vicinity of AgNPs. Moreover, multiple device states were induced by the light irradiation at a wavelength of 600 nm, suggesting that multiple ttbCuPc molecules individually worked as a floating gate.
Physical and antimicrobial properties of quinoa flour‐based films incorporated with essential oil
Authors: Pagno Carlos Henrique , Klug Tâmmila Venzke , Costa Tania Maria Haas , de Oliveira Rios Alessandro , Flôres Simone Hickmann 
Published: January 2016

ABSTRACTFilms of quinoa flour (Chenopodium quinoa, W) incorporated with oregano (Origanum vulgare L.) and thyme (Thymus vulgaris L.) essential oils (EOs) at 0.5%, 1%, and 2% p/p were prepared to examine their physical and mechanical properties and antimicrobial activity against Escherichia coli and Staphylococcus aureus. The type of EO was not significant for the physical and barrier parameters of the films. The increase in the EOs concentration led to an increase in the elongation at break, but decrease in the tensile strength, Young's modulus, solubility and water vapor permeability. Films containing 1% and 2% EOs exhibited an inhibitory effect on the growth of S. aureus and E. coli. However, S. aureus was more sensitive to both EOs and the oregano was more efficient in the inactivation to both microorganisms. The incorporation of EOs as natural antibacterial agents may lead to their potential application as active packaging materials to increase food safety. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43311.