bluuebunny/crossref_metadata_2025_split huggingface dataset:
A - 50 Menstruation Problems and Sleep Interactions: Implications for the Mental Health of Adolescent Females
Authors: Patel Richa , Edwards Naomi , Totah Natalie , Cheu Anastasia , Hickson Robert , Muller-Oehring Eva , Gombert-Labedens Marie , Baker Fiona , Kiss Orsolya , Schulte Tilman 
Published: September 2024

Abstract

Objective
Adolescent females frequently experience internalizing symptoms like sadness and anxiety during this developmental period of hormonal, emotional, and sleep changes. However, the interaction between sleep, menstruation-related challenges, and internalizing symptoms is not currently understood.

Methods
Data from 2814 postmenarcheal female adolescents (Year 3, Mean-age = 13.03, [12–15] years) in the ABCD Study® were analyzed. Internalizing symptom scores were obtained from the Brief Problem Monitor and menstrual cycle characteristics were obtained from a customized questionnaire. The Munich Chronotype Questionnaire measured sleep duration and bedtime. Linear mixed-effect models explored the relationship between menstrual problems, sleep, and internalizing symptoms, with covariates including time since menarche, body mass index, parental education, and socio-demographic factors.

Results
Among adolescent females, greater internalizing problems were associated with menstrual cycle irregularity (p &lt; 0.01), more premenstrual symptoms (p &lt; 0.01), shorter sleep duration (p &lt; 0.01) and later bedtimes (p &lt; 0.01). Those with longer menstrual periods (p &lt; 0.01) and heavier flow (p &lt; 0.01) exhibited higher levels of internalizing symptoms, particularly in those with short sleep duration (p = 0.016, p = 0.003). Additionally, more intense menstrual pain (p &lt; 0.01) and its significant impact on daily activities (p &lt; 0.01) were linked to more internalizing problems; these relationships were both moderated by later bedtimes (pain x bedtime p = 0.004; pain impact x bedtime p = 0.002).

Conclusion
Internalizing symptoms are associated with menstrual cycle characteristics and menstrual pain in female adolescents, especially in those with shorter sleep and later bedtimes. The relationship between the menstrual cycle, sleep, and psychophysiology needs to be integrated in healthcare practice to promote well-being and resilience in young female adolescents.
A - 60 Validity of Caregiver Reported Behavioral Symptoms in Autism Spectrum Disorder Evaluations
Authors: Olsen Aarika , Richard Annette 
Published: September 2024

Abstract

Objective
Informant report of a child’s behavior is an important component of Autism Spectrum Disorder (ASD) evaluations. Informant-report measures with symptom validity scales are crucial to identifying invalid reporting of symptoms. This study examined the prevalence of, and characteristics associated with caregiver-report symptom validity (SVT) failure in an ASD evaluation clinic.

Method
Particpants were 212 youth, 6 to 18 years old (Mage = 11.5, 79.7% white, 91% non-Hispanic) whose caregivers completed a Conners, 3rd Edition, Adaptive Behavior Assessment System (ABAS) 2nd or 3rd Edition, and Child Behavior Checklist (CBCL) as part of a multidisciplinary autism evaluation.

Results
Rates of symptom validity failure, specifically negative impression (z = −3.338, p &lt; 0.001) and inconsistency (z = −2.051, p = 0.04) were significantly higher in this sample compared to the Conners, 3rd edition general population normative sample. Elevated negative impression index was associated with lower scores on the ABAS Social index (r = 0.152, p = 0.028) and higher scores on the CBCL Withdrawn scale (r = −0.285, p &lt; 0.001). Those with an elevated negative impression index were more likely to not receive an ASD diagnosis [Χ2 = 8.116, p = 0.006].

Conclusion
Caregiver report in children seeking diagnostic clarification for ASD is more likely to raise concerns for validity of reported behavioral symptoms than in the general population. Negative impression management is associated with lower likelihood of clinical ASD diagnosis, perhaps suggestive of caregiver motivation to obtain ASD diagnosis for non-autistic children. These findings support consideration of SVT failure when examining caregiver-reported behavioral symptoms.
A - 66 Factors Impacting Appointment No-Shows and Cancellations in Neuropsychology: Predictors for Improving Access to Care for a Diverse Patient Population
Authors: Woolsey Alejandra N , Rosenstein Leslie D , Stagni Alessandra M , Mercano Alejandro Perez , Nieves Emmanuel Rosario 
Published: September 2024

Abstract

Objective
Access to care can be impacted adversely by appointment adherence. We aimed to identify predictors of no-shows and cancellations for neuropsychological services offered by a healthcare system serving diverse communities.

Method
Demographics and appointment status were documented from a sample of 537 consecutive patients scheduled for neuropsychological evaluation at an outpatient psychiatry clinic. Patients included 220 males and 317 females with an average formal education of 11.01 years (SD = 3.87) and age of 55.64 years (SD = 16.2). Chi-square analyses were used to evaluate the association between appointment status and gender, race/ethnicity, payor, availability of a collateral, and MyChart access. Multivariate analysis of variance was used to assess the relationship between age, education, proxy income, and prior no-show rate with appointment status.

Results
The overall rate of no-shows or late cancellations was 20%, and some patients no-showed multiple times. No-shows and late cancellations were associated with historical no-show rates and older age (F = 14.60, p &lt; 0.0001), while race/ethnicity and MyChart activation had slight impacts (χ2 = 5.572, p = 0.062 and χ2 = 3.69, p = 0.055, respectively). Being a monolingual Spanish speaker was associated negatively with MyChart activation, but positively with collateral availability (p &lt; 0.05).

Conclusions
No-show rates, which impact access to care, are high and associated with prior history of no-shows. Other factors, such as MyChart activation and culturally-associated barriers may also impact access. Implementing interventions addressing prior no-show rates and enhancing MyChart access could significantly increase show rates; such improvements could increase patient access to care, reduce the system’s financial burden, and decrease wait times for other patients.
A - 70 Contextualizing Racial/Ethnic Differences in Baseline Assessment among Collegiate Athletes
Authors: Sakamoto McKenna S , Thomas Garrett A , Bradson Megan L , Becnel Breanna J , Arnett Peter A 
Published: September 2024

Abstract

Objective
Compared to other factors that influence neuropsychological test performance, few studies have examined the relationship between racial/ethnic identity and baseline assessment performance in collegiate athletes, and even fewer have contextualized results using structural factors linked to test performance (e.g., premorbid cognitive ability). This study examined racial/ethnic differences in baseline assessment performance before and after controlling for premorbid functioning. We hypothesized that there would be racial/ethnic differences in performance but that controlling for premorbid functioning would reduce these differences.

Method
Participants included 875 collegiate athletes who were grouped based on racial/ethnic identity (White = 661, Black = 165, Another Race = 49) and underwent a comprehensive neuropsychological battery. Cognitive composite scores and intraindividual variability (IIV) were calculated for two neurocognitive domains: attention/processing speed and memory. Premorbid functioning was assessed with the Wechsler Test of Adult Reading (WTAR). ANCOVAs were used to examine racial/ethnic differences in these four cognitive domains before and after controlling for WTAR scores.

Results
Before controlling for WTAR scores, there were significant racial/ethnic differences in the attention/processing speed and memory composite scores and in attention/processing speed IIV, p’s &lt; 0.001, ηp2 = 0.02–0.03. However, there were no significant racial/ethnic differences in memory IIV, p = 0.97. After controlling for WTAR scores, there were no significant racial/ethnic differences in the attention/processing (p = 0.530, ηp2 = 0.001) or memory (p = 0.183, ηp2 = 0.004) composite scores, and the relationship between racial/ethnic identity and attention/processing speed IIV became less significant (p = 0.014, ηp2 = 0.01).

Conclusions
Results suggest that racial/ethnic differences at baseline assessment can be largely accounted for by premorbid functioning, which underscores the importance of considering sociocultural context when assessing racially/ethnically diverse athletes.
A - 72 Cross-Cultural Comparison of Cognitive Performance between Cameroon and the United States in Adults
Authors: Heavens Brittany , Golden Charles , Stripling Ashley , Tchienga Ines 
Published: September 2024

Abstract

Objective
Over the past twenty-five years, the field of neuropsychology has expanded internationally. To date, an accurate understanding of the appropriateness of psychometric tests available in African countries remains limited despite the established need and potential benefits. Given the influence of culture on cognition the current study explores the differences in cognitive test performance between Cameroonian and American adults to add to the existing knowledge base.

Methods
The Cameroonian sample, 250 adults ages 22–72 (mean age = 42.91 [SD = 13.76], 52% male, mean education = 13.54 [SD = 4.58]) resided in Yaoundé, Cameroon. Participants were tested at a district center. Deidentified data from a community mental health center’s archival database comprised the American sample. An independent sample t-test was conducted to examine differences in performance between Cameroonian adults and a matched sample of American adults on selected measures.

Results
The results indicate significant differences between Cameroonians and Americans in cognitive performance on the WAIS-IV Digit Span [t(777) = −31.534, p = 0.013 &lt; 0.05, d = 4.70], Stroop Word [t(823) = −1.117, p = 0.000 &lt; 0.05, d = 13.244], Stroop Color [t(823) = −0.518, p = 0.000 &lt; 0.05, d = 10.443], Stroop Color Word [t(823) = −14.539, p = 0.000 &lt; 0.05, d = 8.999] subtests.

Conclusion
The significant variation in performance between the groups indicates the potential for culturally distinctive functioning and the need for further exploration of how test bias may manifest cross-culturally in neuropsychological assessments within Cameroon. Implications of the current findings include specific recommendations for research and practice within Cameroon to best serve this population.
A - 76 Associations between Proportion of Life Spent in the U.S. and Cognitive Performance in Spanish-Speaking Older Latino Immigrants: Preliminary Findings from the Boston Latino Aging Study
Authors: Solis Isabel , Munera Diana , Bonillas Félix Nikole A , Badillo Cabrera Alex L , Martinez Jairo E , Giudicessi Averi , Vila-Castelar Clara , Ramirez-Gomez Liliana A , Gonzalez Marta , Saldana Daniel , Quiroz Yakeel T 
Published: September 2024

Abstract

Objective
Latinos represent the largest immigrant demographic in the U.S. and are the second-fastest growing minority group. Older Latinos face an increased risk of dementia compared to their non-Hispanic white counterparts. However, there is a notable scarcity of research examining how immigration-related factors among Latinos influence their vulnerability to cognitive decline and dementia. We explored the associations between the proportion of life spent in the U.S. and cognitive performance in older Latino immigrants.

Method
116 Spanish-speaking participants (mean age: 68.8 ± 8.6, educational attainment: 10.5 ± 4.8, 79% female, MMSE: 25.4 ± 3.8) from the Boston Latino Aging Study were included. The adapted Preclinical Alzheimer’s Cognitive Composite-5 (PACC5), comprising the Mini-Mental State Examination-MMSE, Symbol Digit Modalities Test, NEUROPSI-Historias, Free-and-Cued-Selective-Reminding-Test, and Semantic Fluency was used to assess cognition. Spearman’s correlations examined the association between the proportion of life spent in the U.S. (number of years in the U.S./age) and cognition, controlling for age and education.

Results
The proportion of life spent in the U.S. (mean: 41.6 ± 22.7 years) did not significantly correlate with PACC5 performance (ρ = 0.02, p &gt; 0.05). Nonetheless, there was a significant association with global cognitive function (MMSE ρ = 0.19, p = 0.04).

Conclusions
Our initial results did not reveal a correlation between the duration of time spent in the U.S. and the PACC5. However, a higher percentage of years lived in the U.S. correlated with better global cognition. Future studies utilizing larger cohorts are necessary to gain a comprehensive understanding of cognitive health in elderly Latinos, including investigating the effects of immigration-related factors.
A - 85 Age-Related Differences in Cognitive Mechanisms: Exploring the Role of Processing Speed in Working Memory and Prospective Memory
Authors: Killingsworth Derek , Coldiron Allyson M , DiGiovanna Ben J , Motley John E , Tran Sarah H , Carter Ericka , Way Sarah D , Arreola Langarica Ashely L , Barnett Michael D 
Published: September 2024

Abstract

Objective
Research links working memory (WM) and prospective memory (PM) on cognitively demanding tasks. Older adults demonstrate more frontal lobe activation than young adults during WM and PM tasks; however, the underlying mechanisms remain unclear. The current study hypothesized processing speed (PS) as a mediator between WM and PM with age cohort as a possible moderator.

Method
Healthy older adults (n = 80; age 60–89, M = 72.51, SD = 7.08) and young adults (n = 63; age 18–29, M = 19.27, SD = 2.12) were administered WAIS-IV Digit Span, WAIS-IV Coding, and the Virtual Kitchen Protocol for Prospective Memory.

Results
A moderated mediation model revealed that WM positively influenced PM (c:B = 0.69, p &lt; 0.001) with a positive indirect relationship through PS among older adults (ab:B = 0.26, 95% CI [0.13, 0.43]), but not young adults (ab:B = −0.08, 95% CI [−0.19, 0.03]).

Conclusion
PS appears to play a significant role in older adults’ use of WM for PM but not in young adults. This could suggest that older adults recruit additional cognitive resources – those involved in PS – as a compensatory strategy for real-world PM tasks, which would support prior research indicating that diminished functioning in older adults results from reduced ability to redirect neurocognitive networks. Alternatively, age-related declines in PS could be a root cause underlying both worse WM and worse PM in older adults, as postulated by Salthouse. Future research would benefit from further differentiating the direction of influences between WM, PS, and PM in older adults.
A - 89 Systemic Inflammation and Cognitive Performance during Mid-Life: a Complex Longitudinal Relationship
Authors: Persin Michael J , McWhorter Micah L , Bennett Jeanette M 
Published: September 2024

Abstract

Objective
Systemic inflammation, such as interleukin-6 (IL-6) and C-reactive protein (CRP), can affect an individual’s functioning and is a consequence of stress-related physiological changes, especially as one ages. Cognitive functioning is a critical factor of healthy aging and strongly associated with sleep and chronic conditions/symptoms. IL-6 can induce CRP production, leading to downstream effects, however IL-6 levels may also contextualize how CRP may be linked to cognition.

Methods
Using MIDUS waves 2 (M2) and 3 (M3) data, the participants included 770 adults (58.1% Female; 84.9% white; 53.28 ± 10.7 years) who completed two BTACT cognitive assessments over a ten-year period and provided blood samples and psychosocial self-report data at M2. Using PROCESS macro (model 1), we examined the interaction of proinflammatory markers on cognitive decline.

Results
M2 IL-6 interacted with M2 CRP to predict M3 cognition while accounting for age, education, race, gender, sleep, and M2 cognition (ΔR2 = 0.002, F(1,759) = 4.74, p = 0.030). Specifically, among those with lower IL-6, their CRP levels were negatively linked to M3 cognitive performance (b = −0.114, p = 0.007), while for those with higher IL-6, there was no relationship (b = −0.008, p = 0.842).

Conclusion
Findings suggest that a dynamic relationship exists between inflammatory markers and cognitive function. Not only can IL-6 directly affect CRP, it may also provide additional context on how a clinically relevant inflammatory marker may be related to cognitive decline. From a stress and adaptive systems lens, further research should investigate how IL-6 may highlight the accumulation of stressful life events or other chronic psychosocial factors, using a more holistic approach to cognitive aging.
A - 91 Nocturnal Motor Activity and Wake after Sleep Onset and Neuropsychological Health in Veterans with Gulf War Illness
Authors: Reinhard Matthew , Breneman Charity B , Allen Nathaniel , Pollin Kamila U , Chacko Thomas , Summers Angela C 
Published: September 2024

Abstract

Objective
To examine the association between actigraphy-based sleep parameters and neuropsychological health in Veterans with Gulf War Illness (GWI).

Methods
Objective sleep data was obtained from 85 GW Veterans (Mage = 54.2, 79% Male) using an actigraphy monitor (Phillips Respironics Actiwatch-2) worn for 24 hours/day for seven consecutive days. Actigraphy data was manually scored to define time in bed (TIB), and total sleep time (TST), wake after sleep onset (WASO), number of awakenings (NWAK), and motor activity counts (MAC) during sleep were derived using the device software. Participants completed a battery of questionnaires: Patient Health Questionnaire (PHQ-9), Posttraumatic Symptom Checklist (PCL-5), and Pittsburgh Sleep Quality Index (PSQI). Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Correlation analysis was conducted to discover associations between sleep parameters, self-reported measures, and cognitive function.

Results
MAC was positively correlated with elevated scores on PSQI (r = 0.35, p &lt; 0.01), PHQ-9 (r = 0.26, p &lt; 0.05), and PCL-5 (r = 0.26, p &lt; 0.05), and negatively correlated with RBANS Total Index score (r = −0.27, p &lt; 0.05). WASO was also positively correlated with PSQI scores (r = 0.29, p &lt; 0.01). TIB and TST were positively correlated with age (r = 0.25, r = 0.28; all p &lt; 0.05).

Conclusion
Objective parameters of disrupted sleep – nocturnal MAC and WASO – were associated with greater self-reported sleep disturbance. MAC was additionally correlated with increased self-reported symptoms of depression and PTSD, as well as lower performance on a measure of objective cognitive function. This study identifies aspects of sleep disruption as potential sleep intervention targets related to both mood and cognitive symptoms.
A - 93 How Normal Is Normal? Comparison of “within Normal Limits” Patients in a Memory Clinic with Cognitively Healthy Community Volunteers
Authors: Collyer Alexandra , Grueninger Kaite , Cheatham Megan , Gavitt Gabrielle , Roccaforte Analise , LoGalbo Anthony , Webbe Frank 
Published: September 2024

Abstract

Objective
Among patients who present for evaluation at a Memory Disorder Clinic (MDC), a small number are found to have “cognition within normal limits” (WNL). The fact they sought an evaluation suggests WNL may overstate their level of functioning. We compared performance on a brief neurocognitive battery of a recruited sample of healthy older volunteers (HV) to a WNL group from an MDC.

Methods
183 HVs with MoCA score ≥ 25 (M age = 75.07, SD = 5.60; 73% female) and 178 (MDC) patients diagnosed WNL (M age = 77.08, SD = 6.62; 53% female) were administered the Shepherd Verbal Learning Test (SVLT; Gifford & Webbe, 2008); the TOMM; a shortened version of the BNT (MACK-SF4); and the Trailmaking Test (TMT-A&B).

Results
Independent-samples t-tests revealed that HVs had significantly better TMT A & B scores than WNL patients: (M = 33.23, SD = 11.69) vs. (M = 41.19, SD = 15.76), p &lt; 0.001 and (M = 88.98, SD = 35.20) vs. (M = 115.96, SD = 59.61), p &lt; 0.001, respectively. HVs also had significantly better MACK-SF4 scores than WNL (M = 14.31, SD = 1.15) vs. (M = 13.28, SD = 2.27), p &lt; 0.001. No significant group differences were found among SVLT or TOMM scores. WNL was slightly older and less well-educated.

Conclusion
TOMM scores for both groups were above 47, suggesting good effort. Both HVs and WNL patients performed equally well on all SVLT measures. HVs scored significantly better in Trail-making and confrontational naming, suggesting that in WNL executive function and language might be less than “normal.” These mixed outcomes suggest that WNL performance at a Memory Clinic may still fall short of true normal.
A - 94 Comparing Framingham Risk Score and Cognitive Performance in a Black/African American Cohort
Authors: Frydman Alexia J , Bosworth Brooke , Neer Emory , Ortega Alexandra , Correa Rebecca , Carballea Denise , Crenshaw Kirsten Horne , Crocco Elizabeth A , Loewenstein David , Curiel Cid Rosie E 
Published: September 2024

Abstract

Objective
Past research indicates that higher Framingham Cardiovascular Disease Risk Scores (FCVDRS) is associated with decreased cognitive function. Cardiovascular risk factors are strongly associated with cognitive decline, and previous research shows that individuals with a greater number of risk factors have increased levels of cognitive impairment that may manifest well in advance before apparent clinical symptoms. Despite a higher prevalence of cardiovascular risk factors among Black/African Americans (B/AA), research on FCVDRS in this group is lacking. This study explores potential links between FCVDRS and cognitive function in B/AA older adults.

Method
76 B/AA’s (37 female) from a Registry for African American Older Adults at the University of Miami were studied. Data on Framingham Hard Coronary Heart Disease (10-year-risk) and demographic variables were collected. FCVDRS was categorized as low (20%). Cognitive performance was assessed across multiple measures.

Results
There were statistically significant correlations between FCVDRS and performance on 9 of 17 measures of cognition. Specifically, results showed high-risk FCVDRS scores were related to poor performance on measures of general cognition, structured and unstructured verbal memory, processing speed, working memory, phonemic fluency, and visuo-constructional tests.

Conclusion
Previous studies have shown that FCVDRS could be a predictive tool for cognitive decline. However, most research has focused on non-Hispanic White subjects with a higher socioeconomic status. Understanding the association between FCVDRS and cognition across various ethnic groups can inform screening protocols for heterogeneous populations. This study adds to the limited literature on the relationship between FCVDRS and cognition in underserved communities.