bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pre-existence and Persistence of Resistant Minority Hepatitis C Virus Variants in Genotype 1-Infected Patients Treated With Simeprevir/Peginterferon/Ribavirin
Authors: Fevery Bart , Thys Kim , Van Eygen Veerle , Verbinnen Thierry , Van Rossem Elizabeth , Buelens Annemie , Aerssens Jeroen , Witek James , Picchio Gaston , De Meyer Sandra , Lenz Oliver 
Published: March 2016

Abstract
Background.  The pre-existence of minority hepatitis C virus (HCV) variants and their impact on treatment outcome, as well as the persistence of emerging resistant variants posttreatment in patients failing treatment with simeprevir/peginterferon/ribavirin (SMV/PR), were assessed by deep sequencing (DS).
Methods.  Population sequencing (PS) and Illumina DS were performed on HCV genotype 1 isolates from patients treated with SMV/PR in Phase 2b (PILLAR [NCT00882908] and ASPIRE [NCT00980330]) and Phase 3 (QUEST-1 [NCT01289782], QUEST-2 [NCT01290679], and PROMISE [NCT01281839]) trials.
Results.  Minority polymorphisms (ie, detected pretreatment by DS only) reducing SMV activity in vitro were uncommon (3.6%, 19 of 534 patients). These SMV-resistant minority polymorphisms were detected in similar proportions of patients achieving (3.7%) and not achieving (3.3%) sustained virologic response with SMV/PR and generally did not emerge as major variants at time of failure. SMV-resistant variants emerging at time of failure were no longer detected at end of study in 69.3% and 52.0% of the patients by PS and DS, respectively.
Conclusions.  Minority polymorphisms did not impact outcome of SMV/PR treatment. The majority of emerging variants that became undetectable at end of study by PS were also undetectable by DS. These results suggest no added value of DS for clinical usage of SMV.
“Learning to listen”: boys’ gender narratives – implications for theory and practice
Authors: Farrell Francis 
Published: March 2016

Purpose
– The purpose of this paper is to critically investigate year 6 and year 9 boys’ constructions of masculinity in the light of theories of inclusive masculinity and to consider the implications of the findings for critical masculinities scholarship in educational research.

Design/methodology/approach
– Qualitative data was collected through fieldwork in school settings consisting of observations and semi-structured interviews. Data analysis draws upon pro-feminist and post-structuralist theories of the gendered subject.

Findings
– The data shows some evidence of inclusive forms of masculinity expressed by the boys’ rejection of a “boy code” (Pollack, 1999) and their narratives of caring and emotional experience. However, discourses of dominant masculinity persist and continue to shape the boys’ subjectivities. The most striking finding is the capacity of the educational gender work programme reported on in this study to provide boys with the resources to problematise the social construction of masculinity.

Research limitations/implications
– The data suggests analysis in binary terms of inclusive or dominant masculinity fails to recognise the fuzzy educational middle ground occupied by the “overlooked ordinary boys” (Brown, 1987; Roberts, 2012) of this study.

Practical implications
– Educational gender work programmes which provide boys with the resources to question dominant masculine practices enable boys to exceed the “symbolic order” and trouble dominant gender discourse.

Originality/value
– In order to develop nuanced theory and practice researchers need to listen to boys’ accounts of their experiences. Analysis of boys gender work in terms of binary adult constructs of masculinity run the risk of perpetuating the essentialism they purport to avoid rather than producing studies which provide an empirically robust foundation for developing an effective practical educational agenda. In a neo-liberal policy context the role of gender equity programmes with the capacity to produce more reflexive masculine subjects requires reassertion within the curriculum.
Systematic exploration of scenario spaces
Authors: Carlsen Henrik , Eriksson E. Anders , Dreborg Karl Henrik , Johansson Bengt , Bodin Örjan 
Published: March 2016

Purpose– Scenarios have become a vital methodological approach in business as well as in public policy. When scenarios are used to guide analysis and decision-making, the aim is typically robustness and in this context we argue that two main problems at scenario set level is conservatism, i.e. all scenarios are close to a perceived business-as-usual trajectory and lack of balance in the sense of arbitrarily mixing some conservative and some extreme scenarios. The purpose of this paper is to address these shortcomings by proposing a methodology for generating sets of scenarios which are in a mathematical sense maximally diverse.Design/methodology/approach– In this paper, we develop a systematic methodology, Scenario Diversity Analysis (SDA), which addresses the problems of broad span vs conservatism and imbalance. From a given set of variables with associated states, SDA generates scenario sets where the scenarios are in a quantifiable sense maximally different and therefore best span the whole set of feasible scenarios.Findings– The usefulness of the methodology is exemplified by applying it to sets of storylines of the emissions scenarios of the Intergovernmental Panel on Climate Change. This ex-post analysis shows that the storylines were not maximally diverse and given the challenges ahead with regard to emissions reduction and adaptation planning, we argue that it is important to strive for diversity when developing scenario sets for climate change research.Originality/value– The proposed methodology adds significant novel features to the field of systematic scenario generation, especially with regard to scenario diversity. The methodology also enables the combination of systematics with the distinct future logics of good intuitive logics scenarios.
Foresight and the third mission of universities: the case for innovation system foresight
Authors: Piirainen Kalle Artturi , Andersen Allan Dahl , Andersen Per Dannemand 
Published: March 2016

Purpose– This paper aims to argue that innovation system foresight (ISF) can significantly contribute to the third mission of universities by creating an active dialogue between universities, industry and society.Design/methodology/approach– This paper’s approach is conceptual. The authors analyse the third mission and relevant literature on innovation systems and foresight to explain how and why foresight contributes to the third mission.Findings– The authors propose that foresight contributes to the third mission of universities, particularly to the research and development and innovation dimensions through the development of joint understanding of the agendas and future needs of stakeholders. In addition, foresight enables education to be designed to address identified needs.Research limitations/implications– The findings are both conceptual and exploratory in nature. Thus, the argument needs further examination through a broader study on foresight in the university–industry context and/or longitudinal research on the outcomes and impact of foresight in this context.Practical implications– The findings highlight the importance of understanding the systemic nature of innovation and its role in economic development. Universities must understand their role within the larger innovation system to fulfil the potential of economic development and by extension, their third mission.Originality/value– The paper outlines a novel approach of using ISF to promote university–industry partnerships and the growth of innovation systems. The paper also contributes to the discussion of the third mission by outlining that mission in practical terms.
Prospective games for defence strategic decisions in Brazil
Authors: Correa C. R. , Cagnin C. H. 
Published: March 2016

Purpose– This paper aims to propose a model, based on strategic simulation and scenario planning, to improve the decision-making process in the Brazilian defence area.Design/methodology/approach– Participants are disposed in three levels: decision-makers team – which goes beyond the Ministry of Defence (and military services) alone and includes other representatives of the executive and legislative branches; political and strategic advisory team – civilian representatives with a broad understanding of the national and international contexts that can contribute to developing insights and shaping the forces that may contribute to the nation’s future; and experts database— experts in fields of interest to national defence, comprising representatives of several sectors and broad areas of knowledge, including scholars, scientists, politicians, military, industry, among others.Findings– The planning and preparation of national defence strategies require a long-term approach, which is multidisciplinary, participatory and contextualized to the geopolitical and institutional frames of the country.Research limitations/implications– However, despite many policy papers intentions, defence issues have always been considered a matter for the military arena due to the country’s cultural background.Practical/implications– Because decisions about defence have long-range impacts and political implications, policy-makers should shape them bearing in mind a complex and politically shared foresight process.Social/implications– This proposed planning process enables a participatory engagement with some civil organizations and individuals as well as amplifies their commitment in national defence issues.Originality/value– The proposal is innovative in South America, considering that it encompasses integrated simulations on participatory foresight processes as well as broadened the civilian–military dynamic relationship and the diverse viewpoints in defence implications analysis to include a wider share of the Brazilian society.
The impact of strategic organizational orientations on green supply chain management and firm performance
Authors: Kirchoff Jon F , Tate Wendy L , Mollenkopf Diane A 
Published: March 2016

Purpose– Empirical research provides evidence that green supply chain management (SCM) practices positively impact firm performance. Yet, questions remain regarding how firms configure their organizations and design green practices to achieve improved performance, especially in light of a constantly changing business environment. This research uses the resource-based and strategic choice theories to better understand the antecedent roles of two strategic orientations, supply chain orientation (SCO) and environmental orientation (EO), on both the implementation and outcomes of green SCM practices. The paper aims to discuss these issues.Design/methodology/approach– Survey responses from 367 supply chain managers are tested through structural equation modeling.Findings– Findings suggest that a combination of SCO and EO capabilities positively influence the implementation of green SCM practices, and positively impact firm performance. Results also suggest that the capability bundle of SCO, EO, and green SCM should be adaptable to the changing business environment.Originality/value– This research contributes through the combination of the resource-based theory, supported by strategic choice theory, to better understand how managers configure and re-configure valuable green-related capabilities to adapt to the constantly changing business environment.
The benefits of logistics clustering
Authors: Rivera Liliana , Gligor David , Sheffi Yossi 
Published: March 2016

Purpose– The purpose of this paper is to analyze the benefits of logistics clustering, with the intent to explain their growth and popularity among private agents and policy makers during the last decade.Design/methodology/approach– Because of limited knowledge about the benefits of logistics clustering a main objective of this paper is theory building. The authors employed a grounded theory approach and conducted 135 open and semi structured interviews with logistics executives, government officials, academics, and chambers of commerce representatives.Findings– Study results revealed that, the agglomeration of logistics firms provides several key benefits to companies. Specifically, it was found that logistics clustering facilitates collaboration-related benefits, offering of value added services, career mobility for the logistics workforce within the cluster, and promotes job growth at multiple levels within the cluster. The authors offer a rich description of these benefits and the mechanisms that facilitate these outcomes.Research limitations/implications– This paper uses a qualitative approach. Further research using a quantitative approach to measure the magnitude of the impacts and benefits of logistics clusters would be desirable.Originality/value– This paper identifies the benefits associated with logistics clustering and thus provides justification for public authorities and private agents to invest in this phenomenon.
An empirical study on applicability of lean and green practices in the foundry industry
Authors: Prasad Suresh , Khanduja Dinesh , Sharma Surrender K. 
Published: March 2016

Purpose
– The purpose of this paper is to investigate the applicability of lean and green practices to foundry industry in India for improving productivity and eliminating waste, incorporating the sustainability into business performance measures.

Design/methodology/approach
– The study used survey questionnaire method to collect data against 16 lean and green practices from 71 middle- to senior-level professionals belonging to Indian foundry industry. The survey instrument of lean and green practices was developed based on a number of sources from the literature and formal discussions with academicians and foundry industry professionals. The responses were received on a five-point Likert scale ranging from least applicable to most applicable. Exploratory factor and reliability analyses are conducted to obtain and validate constructs and measure each constructs Cronbach’s α (i.e. a consistency coefficient). The lean and green practices are categorized into the four constructs, namely, workplace organization practices, management practices, inventory control practices, and industrial manufacturing and quality improvement practices. Further, descriptive statistics is employed to find out the relative significance of lean and green practices.

Findings
– Factor and reliability analyses show that all four constructs are adequate and reliable to illustrate lean and green practices. Descriptive statistics indicates that lean and green practices are applicable for implementation to a certain extent in the foundry industry. Correlation analysis shows that lean practices are positively and moderately interrelated with green practices. Thus, the results present a strong evidence that lean and green practices are moderately applicable for implementation in the foundry industry.

Originality/value
– The paper provides insights into the applicability of lean and green practices implementation in the context of a developing country and presents evidence that lean and green practices are moderately applicable in the foundry industry. In addition, this paper is one of the few efforts to promote sustainable development within the industry.
Just-in-time: organizing the Lakota Sun Dance
Authors: Modaff Daniel Paul 
Published: March 2016

Purpose
– The purpose of this paper is to investigate the organizing practices of a Lakota Sun Dance, and to contribute to the literature on rituals and ceremonies in organizational culture.

Design/methodology/approach
– The researcher acted as participant-as-observer during this extended ceremony. Fieldnotes capturing observations and informal interviews with Lakota elders were the source of data as recording devices were not permitted on the Sun Dance grounds. Observations were conducted for approximately 45 hours over the course of five days.

Findings
– The Lakota Sun Dance can be understood through organizational theory, particularly through a unique integration of the concepts of agency, loosely coupled systems, and just-in-time organizing. The current research highlights the role of agency in organizational ceremonies.

Originality/value
– This research offers a thick description of the organizing practices of an extended Lakota ceremony. The integration of traditional Lakota organizing principles with modern organizational theory is absent from the literature, and offers a unique perspective on organizing from a non-Western perspective.
Planning an accessible expo 2020 within Dubai’s 5 star hotel industry from legal and ethical perspectives
Authors: Morris Stephanie , Kazi Scolah 
Published: March 2016

Purpose
The purpose of this paper is to provide an understanding of the accessibility laws currently in effect in the United Arab Emirates and, specifically, Dubai. Further, it recommends methods of integrating accessible hospitality and tourism in Dubai with core legal and ethical direction in preparation for EXPO 2020.

Design/methodology/approach
Review of current legislation and analysis of interpretation by industry providers was used to illustrate the impact on the current accessibility environment in Dubai and to recommend a revised regulatory scheme.

Findings
The paper explains how legal and ethical issues have influenced the planning and building of 5 star hotels in Dubai, and offers recommendations for amendments and additions to the region’s current laws that address needs of people with disabilities (PwD).

Originality/value
Little research has been conducted in the region concerning the rights and needs of PwD. The paper significantly contributes by demonstrating how an ethical and legal framework will address the needs of PwD thereby aiding in Dubai’s successful hosting of EXPO 2020. This contribution is notably opportune in view of the anticipated changes in applicable legislation.
Past, present and future of tourist tracking
Authors: Thimm Tatjana , Seepold Ralf 
Published: March 2016

Purpose
The purpose of this paper is to find out tourism movement patterns via the tracking of tourists with the help of positioning systems like GPS in the rural area of the Lake Constance destination in Germany. In doing so past, present and future of tourist tracking is illustrated.

Design/methodology/approach
The tracking is realized via common smartphones extended by an app, with dedicated sensors like position loggers and a survey. The three different approaches are applied in order to compare and cross-check results (triangulation of data and methods).

Findings
Movement patterns turned out to be diverse and individualistic within the rural destination of Lake Constance and following an ants trail in sub-destinations like the city of Constance. Repeat visitors and first-time visitors alike always visit the bigger cities and main day-trip destinations of the Lake. A possible prediction tool enables new avenues of governing tourism movement patterns.

Research limitations/implications
The tracking techniques can be developed further into the direction of “quantified self” using gamification in order to make the tracking app even more attractive.

Practical implications
An algorithm-based prediction tool would offer new perspectives to the management of tourism movements.

Social implications
Further research is needed to overcome the feeling of invasiveness of the app to allow tracking with that approach.

Originality/value
This study is original and innovative because of the first-time use of a smartphone app in tourist tracking, the application on a rural destination and the conceptual description of a prediction tool.
A framework for planning academic library spaces
Authors: Choy Fatt Cheong , Goh Su Nee 
Published: March 2016

Purpose
– The focus on designing spaces for users in the last decade or so signifies the gradual change in the mission of libraries from provision of resources to that of a pro-active partner in learning. Planning for user space in support of learning is far more complex as it needs to take into account the variety of users’ needs and behaviour. Before specifying the actual layout and design of users’ spaces it is important to consider all the major factors that affect the use of the intended library space. The purpose of this paper is to provide a guide to library planning base on the experience of the authors at Nanyang Technological University (NTU) Libraries.

Design/methodology/approach
– The framework for planning library spaces developed at NTU Libraries consists of four components – collaborative space, sanctuary space, interaction space and community space. Discussion on the rationale of these spaces and suggestions for their implementation will assist others in asking appropriate questions on their own library space planning exercise.

Findings
– The paper reinforced the view that a good library building has to provide a wide variety of spaces, some of which are contradictory as the needs of a student is different from another. A student also has different needs at different times. Providing and balancing these needs is essential.

Originality/value
– This paper provides a tried and tested conceptual framework for use by library space designers.
Intangible organizational resources in Polish libraries
Authors: Wojciechowska Maja Dorota 
Published: March 2016

Purpose
– The purpose of this paper is to present the main assumptions of the resource-based theory according to which the success of an organization is mainly dependent on the ability of capitalizing its inner capacity. The author draws attention to the measurement of intangible resources of libraries and their evaluation, crucial from the point of view of library effectiveness and the quality of its services. The author also emphasizes the specific character of intangible resources, including lack of their mobility, specialization and difficulty in their replacing, which may result in hindering management processes.

Design/methodology/approach
– The second part of the paper illustrates the author’s research in the field of intangible resources in Polish libraries, including human resources (knowledge, competencies, employee skills), competencies of library management staff, business strategies, organizational culture, communication skills and relations between employees, the ability to communicate and relations with the library community, in particular with its users, library reputation, brand, library innovativeness and the ability to adapt to changes and expectations of the community, the ability of the library to cooperate with other institutions, including networks and consortia, the ability to use and support new technological solutions, the ability to introduce new technologies in the library, the ability to create and acquire intellectual property (copyright, licensing, trademark protection, etc.).

Findings
– Research has shown that libraries pay growing attention to the relation with the community. Concentrating on library resources means concentrating on readers and providing services that would satisfy readers. However, it seems that the knowledge of library management in the field of managing of intangible resources is still insufficient.

Originality/value
– The paper presents the first study of this kind conducted in Poland.