bluuebunny/crossref_metadata_2025_split huggingface dataset:
Use of menopausal hormone therapy before and after diagnosis and ovarian cancer survival—A prospective cohort study in Australia
Authors: Na Renhua , Jordan Susan J. , DeFazio Anna , Williams Merran , Livingstone Karen , Obermair Andreas , Friedlander Michael , Grant Peter , Webb Penelope M. ,   for the OPAL Study Group
Published: September 2024

AbstractMenopausal hormone therapy (MHT) use before ovarian cancer diagnosis has been associated with improved survival but whether the association varies by type and duration of use is inconclusive; data on MHT use after treatment, particularly the effect on health‐related quality of life (HRQOL), are scarce. We investigated survival in women with ovarian cancer according to MHT use before and after diagnosis, and post‐treatment MHT use and its association with HRQOL in a prospective nationwide cohort in Australia. We used Cox proportional hazards regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) and propensity scores to reduce confounding by indication. Among 690 women who were peri‐/postmenopausal at diagnosis, pre‐diagnosis MHT use was associated with a significant 26% improvement in ovarian cancer‐specific survival; with a slightly stronger association for high‐grade serous carcinoma (HGSC, HR = 0.69, 95%CI 0.54–0.87). The associations did not differ by recency or duration of use. Among women with HGSC who were pre‐/perimenopausal or aged ≤55 years at diagnosis (n = 259), MHT use after treatment was not associated with a difference in survival (HR = 1.04, 95%CI 0.48–2.22). Compared to non‐users, women who started MHT after treatment reported poorer overall HRQOL before starting MHT and this difference was still seen 1–3 months after starting MHT. In conclusion, pre‐diagnosis MHT use was associated with improved survival, particularly in HGSC. Among women ≤55 years, use of MHT following treatment was not associated with poorer survival for HGSC. Further large‐scale studies are needed to understand menopause‐specific HRQOL issues in ovarian cancer.
Humoral immune response as an indicator for protection against Covid‐19 after anti‐SARS‐COV2‐booster vaccination in hematological and oncological patients
Authors: Mainka Dieter , Bauer Nathalie , Dietze Lutz , Lehnert Sonja , Krandick Johanna , Himmelreich Daniel , Jomaa Hassan , Zimmermann Maximilian , Borchmann Peter , Herbrandt Swetlana , Rothe Achim 
Published: September 2024

AbstractCancer patients are at a higher risk to develop severe COVID‐19 symptoms after SARS‐CoV‐2 infection compared to the general population and regularly show an impaired immune response to SARS‐CoV‐2 vaccination. In our oncological center, 357 patients with hematological and oncological diseases were monitored for neutralizing antibodies from October 2021 over 12 months. All patients had received three anti‐SARS‐CoV‐2 vaccinations with an mRNA—(Comirnaty/BionTech or Spikevax/Moderna) or a vector vaccine (Vakzevria/AstraZeneca or JCOVDEN/Johnson&Johnson). Neutralizing anti‐SARS‐CoV‐2 IgG antibodies in the patients' sera were detected within 3 months before, 3–10 weeks and 5–7 months after the booster vaccination (third vaccination). 112 patients developed a breakthrough SARS‐CoV‐2 infection during the observation period. High anti‐SARS‐Cov‐2 antibody levels before infection significantly protected against symptomatic Covid‐19 disease (p = .003). The median antibody titer in patients with asymptomatic Covid‐19 disease was 2080 BAU/ml (binding antibody units per Milliliter) and 765 BAU/ml in symptomatic patients. 98% of the solid tumor patients reached seroconversion after the booster vaccination in comparison to 79% of the hematological patients. High antibody titers of >2080 BAU/ml after the booster vaccination were detected in 61% of the oncological and 34.8% of the hematological patients. 7–10 months after the booster vaccination, the anti‐SARS‐CoV‐2 antibody titer declined to an average of 849 BAU/ml. Considering the heterogenous humoral immune response of cancer patients observed in this study, an individual vaccination strategy based on regular measurement of anti‐SARS‐CoV‐2 antibody levels should be considered in contrast to fixed vaccination intervals.
A case report of troubleshooting against bleeding from inferior vena cava injury
Authors: Shibuya Tadamasa , Inoue Toru , Ando Tadasuke , Shin Toshitaka 
Published: September 2024

IntroductionWe report a case of troubleshooting against bleeding from an inferior vena cava injury using a gelatin–thrombin matrix.Case presentationA 58‐year‐old man underwent robot‐assisted partial adrenalectomy for a right adrenal adenoma causing subclinical Cushing's syndrome. During the surgery, while dissecting between the adrenal gland and the inferior vena cava, bleeding occurred secondary to an inferior vena cava injury. Despite attempts at hemostasis, applying a human fibrinogen–thrombin patch and suturing were both difficult because of poor vision secondary to the bleeding. Hemostasis was ultimately achieved using a gelatin–thrombin matrix, which was accurately placed on the bleeding point using gauze. Open conversion was hence avoided, allowing the completion of the surgery as planned.ConclusionGelatin–thrombin matrix may be effective for managing relatively small inferior vena cava injuries.
BODIPY‐based iridium and ruthenium complexes: Synthesis, photophysical, and photochemical properties
Authors: Cabir Beyza , Cetindere Seda 
Published: September 2024

AbstractThe design, synthesis, and characterization of novel BODPY‐based iridium and ruthenium complexes were reported. The structures of new compounds were fully characterized by FT‐IR, MALDI‐TOF mass analysis, elemental analysis, 1H, and 19F NMR spectroscopies. Precursor BODIPY was characterized by single‐crystal x‐ray diffraction technique for the first time. Photophysical properties including absorption and emission profiles and lifetimes were investigated via UV–vis absorption and emission spectroscopy. Photochemical properties were investigated via direct method, and the singlet oxygen production capabilities of new complexes were determined by NIR phosphorescence methods. BODIPY‐based new complexes were efficient at producing 1O2. Besides, both complexes showed more remarkable photosensitization ability than some commonly used photosensitizer based on BODIPY derivatives. This study points out that novel complexes are effective 1O2 photosensitizers that might be used for different application areas like photodynamic therapy.
Comparative efficacy of aspirin versus direct oral anticoagulants for venous thromboembolism prophylaxis following primary total hip arthroplasty or total knee arthroplasty: A systematic review and meta‐analysis of randomised controlled trials
Authors: Syed Fauzaan Ali , Amin Hamzah , Benjamin Biju , Hendrix Michiel , Savaridas Terence 
Published: September 2024

AbstractIntroductionVenous thromboembolisms (VTEs), including deep vein thrombosis (DVT) and pulmonary embolisms (PE), are common after total knee (TKA) and hip arthroplasty (THA). Recent studies suggest that aspirin effectively prevents VTE following major orthopaedic surgery. This meta‐analysis compares randomised controlled trials (RCTs) evaluating aspirin versus direct oral anticoagulants (DOACs) for VTE prevention after primary THA and TKA.MethodsWe included RCTs from 2017 to 2023 that looked at aspirin versus DOACs for VTE prophylaxis in primary THA and TKA. A search strategy was conducted which used Boolean operators and MESH terms. Primary outcomes included VTE rates, symptomatic, asymptomatic DVT and PE. Secondary outcomes were mortality and bleeding complications. Statistical analysis was performed using REVMAN software. An odds ratio with a 95% confidence interval was generated for the pooled studies. Heterogeneity was assessed using the I2 variable, and publication bias was evaluated with a funnel plot.ResultsSeven RCTs with 3967 patients were included for analysis. Rivaroxaban 10 mg OD was compared to varying doses of aspirin (81–300 mg). There were no significant differences between the groups in the incidence of VTE (OR: 1.21, 95% CI: 0.72–2.01), PE (OR: 1.01, 95% CI: 0.39–2.61), asymptomatic DVT (OR: 1.39, 95% CI: 0.64–3.00), suspected DVT (OR: 1.13, 95% CI: 0.49–2.61) and major bleeding (OR: 0.84, 95% CI: 0.55–1.27).DiscussionAspirin is as effective as rivaroxaban for primary thromboprophylaxis post‐THA and TKA, without increased incidence of complications. Further research is needed to determine the optimal dosing regimen of aspirin and its long‐term efficacy in preventing VTE.Level of EvidenceLevel I.
An aptamer‐guided fluorescence polarisation platform for extracellular vesicle liquid biopsy
Authors: Pham Cuong Viet , Chowdhury Rocky , Patel Shweta , Jaysawal Satendra Kumar , Hou Yingchu , Xu Huo , Jia Lee , Zhang Yu‐mei , Wang Xiaowei , Duan Wei , Xiang Dongxi 
Published: September 2024

AbstractThe translation of discoveries on extracellular vesicle (EV) based cancer biomarkers to personalised precision oncology requires the development of robust, sensitive and specific assays that are amenable to adoption in the clinical laboratory. Whilst a variety of elegant approaches for EV liquid biopsy have been developed, most of them remain as research prototypes due to the requirement of a high level of microfabrication and/or sophisticated instruments. Hence, this study is set to develop a simple DNA aptamer‐enabled and fluorescence polarisation‐based homogenous assay that eliminates the need to separate unbound detection ligands from the bound species for EV detection. High specificity is achieved by immobilising EVs with one set of antibodies and subsequently detecting them with a DNA aptamer targeting a distinct EV biomarker. This two‐pronged strategy ensures the removal of most, if not all, non‐EV substances in the input biofluids, including soluble proteins, protein aggregates or non‐vesicular particles, prior to quantifying biomarker‐positive EVs. A limit of detection of 5.0 × 106 EVs/mL was achieved with a linear quantification range of 5.0 × 108 to 2.0 × 1010 EVs/mL. Facilitated by a multiple parametric analysis strategy, this aptamer‐guided fluorescence polarisation assay was capable of distinguishing EVs from three different types of solid cancer cells based on quantitative differences in the levels of the same sets of biomarkers on EVs. Given the simplicity of the method and its ease of implementation in automated clinical biochemistry analysers, this assay could be exploited for future EV‐based continuous and real‐time monitoring of the emergence of new macro‐ or micro‐metastasis, cancer progression as well as the response to treatment throughout different stages of cancer management in the clinic.
Clinical guideline highlight for the hospitalist: Diagnosis and management of acute bacterial arthritis in children
Authors: Palmer Brandon , Cummings Austin , Hahn Danita 
Published: September 2024

GUIDELINE TITLE: Clinical Practice Guideline by the Pediatric Infectious Diseases Society (PIDS) and the Infectious Diseases Society of America (IDSA): 2023 Guideline on Diagnosis and Management of Acute Bacterial ArthritisRELEASE DATE: January 1, 2024PRIOR VERSION(S): n/aDEVELOPER: Pediatric Infectious Diseases Society (PIDS), Infectious Diseases Society of America (IDSA)FUNDING SOURCE: PIDS and IDSATARGET POPULATION: Children with suspected or confirmed acute bacterial arthritis
Mixed motives behind migrants' remittance‐sending practices: Evidence from China
Authors: Xu Licheng 
Published: September 2024

AbstractAn abundant collection of literature investigates why migrants remit. Migrants' remittance‐sending practices can be driven by either altruism or the insurance motive. In this study, I first develop a stylized theoretical framework that generates testable predictions regarding the two frequently discussed motives. Then, using a panel data set pooled from three waves of the China Laborforce Dynamic Survey (2012–2016), I find empirical evidence for migrants' remittance‐sending practices under mixed motives that incorporate both altruism and insurance. Findings presented in this study are of great significance in understanding family ties and the risk sharing mechanism between rural‐to‐urban migrants and households of origin.
Long‐term assessment of macro‐ and micronutrients in foliage of European beech (Fagus sylvatica L.) in thinned versus unmanaged old‐growth stands
Authors: Borys Alexander , Wieczorek Barbara , Nicke Anka , Walstab Jutta 
Published: September 2024

AbstractBackgroundScience‐based decisions regarding forest management require the knowledge of the impact of thinning regimens on the forests’ vitality and resilience. There is no systematic study analysing the role of forest management approaches on the nutritional status of forests, serving as a surrogate for their health and growth.AimsWe assessed the impact of ‘heavy thinning from above’ versus ‘no management’ on the foliar chemistry of old‐growth European beech stands on a calcareous site with cambisol/chromic luvisol soil in Thuringia, Germany.MethodsMacro‐ and micronutrients were analysed by serial foliar analysis of six trees per experimental plot over 13 years (2009–2021). To assess potential differences of foliar chemistry between the two plots and over time, a linear mixed‐effects model was applied.ResultsFoliar concentrations of all macro‐ and micronutrients were not significantly different between the two plots (p > 0.05), demonstrating that the management approach had no relevant impact on the nutritional status of beech trees growing at the calcareous site. Furthermore, all foliar concentrations were dynamic over the 13‐year evaluation period. Hence, long‐term forest monitoring is crucial to capture the complex interplay between the trees and environmental conditions.ConclusionsSerial foliar analysis allows for a reliable evaluation of a forest's nutritional status. The results indicate that either regimen, that is, ‘heavy thinning from above’ or ‘no management’, shall not pose any risk in terms of growth and stability. Our results add to the understanding of beech forest dynamics and may provide a further piece for science‐based strategies of sustainable forest management.
Quantitative Raman Spectroscopy of Urea and Thiourea in the Reaction Mixtures of Allantoin and 4,5‐Dihydroxyimidazolidine‐2‐Tione Formation
Authors: Kalichkina L. E. , Krivolapenko P. K. , Tuguldurova V. P. 
Published: September 2024

ABSTRACTThe present work introduces a new approach to quantitative determine the reagent concentrations (thiourea and urea) using in situ Raman spectroscopy in the reaction mixture exemplified by the reactions of formation of allantoin and 4,5‐dihydroxyimidazolidine‐2‐thione. The approach comprises the use of a commercially available immersion probe (MarqMetrix Process Elite BallProbe with sapphire lens) as a standard for the immersion probe band at 790 cm−1 of optical glass. This leads to a linear dependence of the ratio of the intensity of non‐overlapping analyte bands at 1003 cm−1 of ‐C‐N‐ vibrations in urea to the one of the 790 cm−1 immersion probe band on the concentration of urea in the test solution. The definable method parameters such as precision (repeatability and reproducibility), linearity, limit of detection (LoD), limit of quantitation (LoQ), and accuracy were determined. The quantitative Raman spectroscopy method is linear, precise within the range of determined concentrations from 0.75 to 2.00 M and can be used to calculate the kinetics of allantoin formation. Using thiourea as an example, it is shown that despite the partial overlap of the analyte band at 730 cm−1 of the ‐C=S vibrations of thiourea with the immersion probe band at 790 cm−1, the method to determine thiourea in the reaction of 4,5‐dihydroxyimidazolidine‐2‐thione preparation is also linear and precise in the range of determined concentrations from 0.10 to 1.57 M.
Recyclable and Stable Strain Sensors Based on Semi‐Wrapped Structure of Silver Nanowires in Polyvinyl Alcohol for Human Motion Monitoring
Authors: Chen Yiyi , Li Yanlin , Zhang Qi , Peng Ting , Yu Huangzhong , Shi Shengwei 
Published: September 2024

AbstractHighly sensitive strain sensors have been widely used in human motion monitoring, medical treatment, soft robots, and human–computer interaction, and the recycling of functional materials is in a huge demand for eco‐friendly and sustainable electronics. However, the manufacturing of recyclable strain sensors still remains challenging. Here, a semi‐wrapped structure based on silver nanowires and polyvinyl alcohol is proposed to realize a recyclable and stable strain sensor. It has shown excellent sensitivity, fast response, high stretchability and good environmental stability, and is successfully applied for human motion monitoring. In addition, a simple strategy is developed to effectively recycle silver nanowires in an eco‐friendly manner. The recyclable and stable strain sensor demonstrates potential applications in wearable and stretchable electronics, and the recycling strategy can be extended to other noble metal nanomaterials.
Localized operators on weighted Herz spaces
Authors: Ho Kwok‐Pun 
Published: September 2024

AbstractWe introduce the notion of localized operators. We extend the boundedness of the localized operators from the weighted Lebesgue spaces to the weighted Herz spaces. The localized operators include the Hardy operator, the Riemann–Liouville fractional integrals, the general Hardy‐type operators, the geometric mean operator, and the one‐sided maximal function. Therefore, this paper extends the mapping properties of the the Hardy operator, the Riemann–Liouville fractional integrals, the general Hardy‐type operators, the geometric mean operator, and the one‐sided maximal function to the weighted Herz spaces.
A Novel Heterozygous Intronic FBN1 Variant Contributes to Aberrant RNA Splicing in Marfan Syndrome
Authors: Dougarem Djouhayna , Chen Yi‐Xiao , Sun Yi‐Na , Huang He‐Feng , Luo Qiong 
Published: September 2024

ABSTRACTBackgroundMarfan syndrome (MFS) is a complex genetic systemic connective tissue disorder. It is well known that genetic factors play a critical role in the progression of MFS, with nearly all cases attributed to variants in the FBN1 gene.MethodsWe investigated a Chinese family with MFS spanning two generations. Whole exome sequencing, in silico analysis, minigene constructs, transfection, RT‐PCR, and protein secondary structure analysis were used to analyze the genotype of the proband and his father.ResultsThe main clinical manifestations of the proband and his father were subluxation of the left lens and high myopia with pectus deformity. Whole exome sequencing identified a novel single nucleotide variant (SNV) in the FBN1 gene at a non‐canonical splice site, c.443‐3C>G. This variant resulted in two abnormal mRNA transcripts, leading to a frameshift and an in‐frame insertion. Further in vitro experiments indicated that the c.443‐3C>G variant in FBN1 was pathogenic and functionally harmful.ConclusionThis research identified a novel intronic pathogenic FBN1: c.443‐3C>G gene variant, which led to two different aberrant splicing effects. Further functional analysis expands the variant spectrum and provides a strong indication and sufficient basis for preimplantation genetic testing for monogenic disease (PGT‐M).
Management of a Complex, Recurrent Case of Medial Thigh Sarcoma With Pedicled Deep Inferior Epigastric Artery Perforator (DIEP) Lymphatic Flow‐Through (LyFT) Flap and Secondary Anterolateral Thigh (ALT) Free Flap With Innervated Vastus Lateralis Anastomosed to Synthetic Artery Graft: A Case Report
Authors: Martini Federica , Meroni Matteo , Scaglioni Mario F. 
Published: September 2024

ABSTRACTSoft‐tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin and account for only 1% of adult malignancies. They tend to occur most commonly in the lower extremities. Reconstruction after sarcoma resection can be challenging, especially when important structures are involved and recurrences occur. Additionally, more attention is now being paid to reconstructing the lymphatic system to prevent lymphatic complications. In this case report, we presented the management of recurrent medial thigh sarcoma that necessitated multiple challenging reconstructions to provide valuable insights for lectures on similar cases. A 50‐year‐old male patient was diagnosed with an undifferentiated pleomorphic cell sarcoma (UPS) of the anteromedial thigh. After preoperative radiotherapy, a mass of 23 × 15 cm was removed, and reconstruction with a pedicled deep inferior epigastric artery perforator (p‐DIEP) flap‐based lymphatic flow through (LyFT) was performed. Six months later, the patient developed the first local recurrence with the presence of a distant metastasis. Following the tumor resection, the medial part of the DIEP flap was de‐epithelized and buried in the defect for dead space obliteration. Another local recurrence arose 7 months after the second surgery. Therefore, a major debulking surgery involving the femoral neurovascular bundle was performed. The femoral artery was reconstructed with a synthetic graft, and the femoral vein with the great saphenous vein harvested from the contralateral thigh. A composite myocutaneous neurotized anterolateral thigh (ALT) flap from the contralateral thigh was used to obliterate the defect and restore the loss of function of the quadriceps femoris. Two lymphaticovenular anastomoses (LVAs) were performed at the ankle to reduce the risk of lymphatic sequelae. This case report highlights the importance of integrating various techniques to create a tailored approach that effectively addresses complex surgical requirements to avoid limb amputation and maintain functionality.
QRAGE—Simultaneous multiparametric quantitative MRI of water content, T1, T2*, and magnetic susceptibility at ultrahigh field strength
Authors: Zimmermann Markus , Abbas Zaheer , Sommer Yannic , Lewin Alexander , Ramkiran Shukti , Felder Jörg , Worthoff Wieland A. , Oros‐Peusquens Ana‐Maria , Yun Seong Dae , Shah N. Jon 
Published: September 2024

AbstractPurposeTo introduce quantitative rapid gradient‐echo (QRAGE), a novel approach for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, and magnetic susceptibility at ultrahigh field strength.MethodsQRAGE leverages a newly developed multi‐echo MPnRAGE sequence, facilitating the acquisition of 171 distinct contrast images across a range of TI and TE points. To maintain a short acquisition time, we introduce MIRAGE2, a novel model‐based reconstruction method that exploits prior knowledge of temporal signal evolution, represented as damped complex exponentials. MIRAGE2 minimizes local Block‐Hankel and Casorati matrices. Parameter maps are derived from the reconstructed contrast images through postprocessing steps. We validate QRAGE through extensive simulations, phantom studies, and in vivo experiments, demonstrating its capability for high‐precision imaging.ResultsIn vivo brain measurements show the promising performance of QRAGE, with test–retest SDs and deviations from reference methods of < 0.8% for water content, < 17 ms for T1, and < 0.7 ms for T2*. QRAGE achieves whole‐brain coverage at a 1‐mm isotropic resolution in just 7 min and 15 s, comparable to the acquisition time of an MP2RAGE scan. In addition, QRAGE generates a contrast image akin to the UNI image produced by MP2RAGE.ConclusionQRAGE is a new, successful approach for simultaneously mapping multiple MR parameters at ultrahigh field.