bluuebunny/crossref_metadata_2025_split huggingface dataset:
Migraciones, digitalizaciones y prácticas educativas en el contexto argentino
Authors: Esnaola Horacek Graciela A. , Ottaviano Melania Liliana , Palacios Nilda Graciela 
Published: December 2015

<p>La migración lectora hacia la digitalización de la palabra escrita conlleva la diversificación de componentes ajustados al nuevo formato digital. El tránsito del proceso lector a través de vínculos hipertextuales se modifica incorporando nuevas competencias cognitivas que amplían los significados que el propio autor de la obra diseñó antes de la producción. Estudiando este tránsito desde nuestras primeras investigaciones (Esnaola Horacek, 2003) hasta el escenario actual de Argentina en particular, y en el mundo en general, las pantallas han ganado espacios con una ubicuidad y transparencia muy significativa. Sostenemos que este proceso de mutación<br />en los formatos estéticos va generando “residuos cognitivos” (San Martín Alonso, 1995, p 158) en la “mente alfabética” (Havelock, 1982) que el proceso lectoescritor implica, incorporando procesos propios de la “lectura calidoscópica” (Murray, 1997) que promueven estos nuevos entornos. Este proceso atravesó los muros de todas las instituciones, en particular a la escuela, transformando la superficie del papel en los cristales de las pantallas.</p><p>Los datos analizados llevan a reflexionar sobre el impacto que este panorama implica para la formación del lector crítico y del productor creativo de textos, desde el profesorado y las múltiples transformaciones<br />que renuevan a la clásica figura del “libro de texto escolar”. Abrimos la lectura de los múltiples sentidos del mundo contemporáneo a través de los hipermedios que convocan a transitar en “el jardín de los senderos que se bifurcan” que Borges anticipó en 1941...</p>
Feasibility and acceptability of mobile phone short message service as a support for patients receiving antiretroviral therapy in rural Uganda: a cross‐sectional study
Authors: Kim Jiho , Zhang Wendy , Nyonyitono Maureen , Lourenco Lillian , Nanfuka Mastula , Okoboi Stephen , Birungi Josephine , Lester Richard T , Kaleebu Pontiano , Munderi Paula , Moore David M 
Published: December 2015

IntroductionMobile phone technologies have been promoted to improve adherence to antiretroviral therapy (ART). We studied the receptiveness of patients in a rural Ugandan setting to the use of short messaging service (SMS) communication for such purposes.MethodsWe performed a cross‐sectional analysis measuring mobile phone ownership and literacy amongst patients of The AIDS Support Organisation (TASO) in Jinja, Uganda. We performed bivariate and multivariate logistic regression analyses to examine associations between explanatory variables and a composite outcome of being literate and having a mobile phone.ResultsFrom June 2012 to August 2013, we enrolled 895 participants, of whom 684 (76%) were female. The median age was 44 years. A total of 576 (63%) were both literate and mobile phone users. Of these, 91% (527/ 576) responded favourably to the potential use of SMS for health communication, while only 38.9% (124/319) of others were favourable to the idea (p<0.001). A lower proportion of literate mobile phone users reported optimal adherence to ART (86.4% vs. 90.6%; p=0.007). Male participants (AOR=2.81; 95% CI 1.83–4.30), sub‐optimal adherence (AOR=1.76; 95% CI 1.12–2.77), those with waged or salaried employment (AOR=2.35; 95% CI 1.23–4.49), crafts/trade work (AOR=2.38; 95% CI 1.11–5.12), or involved in petty trade (AOR=1.85; 95% CI 1.09–3.13) (in comparison to those with no income) were more likely to report mobile phone ownership and literacy.ConclusionsIn a rural Ugandan setting, we found that over 60% of patients could potentially benefit from a mobile phone‐based ART adherence support. However, support for such an intervention was lower for other patients.
Transformation of the nickel donor center by annealing in silicon measured by deep-level transient spectroscopy
Authors: Nakamura Minoru , Murakami Susumu , Udono Haruhiko 
Published: December 2015

Abstract
The concentration changes of nickel-related species after thermal annealing in Schottky electrode-formed (EL-formed) and electrode-free (EL-free) p-type silicon samples diffused with nickel were measured by deep-level transient spectroscopy. The nickel donor center began to decay at approximately 100 °C with the activation energies of 1.06 and 0.26 eV for the EL-formed and EL-free samples, respectively, which were analyzed as the required energies for the center to form complexes with interstitial nickel (Nii) and hydrogen, respectively. These complexes evolved into extended complexes by further bonding of Nii at higher annealing temperatures. All the complexes above disappeared by evolving into precipitates within temperatures lower than 400 °C without recovering the nickel donor center. The transformation reactions of the complexes progressed at lower temperatures and shorter times in the EL-formed samples than in the EL-free samples because of the electric neutralization of the nickel-related species in the space-charge region of the electrode.
Co2MnSi Heusler alloy as an enhancing layer of perpendicular magnetic anisotropy for MgO-based magnetic tunnel junctions with L10 ordered FePd
Authors: Bae Taejin , Ko Jungho , Lee Sangho , Cha Jongin , Hong Jongill 
Published: December 2015

Abstract
Ultra-thin Co2MnSi Heusler alloy improves perpendicular magnetic anisotropy of FePd in an MgO-based magnetic tunnel junction after annealing it just once at a temperature of as low as 400 °C. Co2MnSi as thin as 1.0 nm inserted between MgO and FePd facilitated phase-transformation of 3-nm-thick FePd to ordered L10 and led a change in magnetic anisotropy to perpendicular-to-the-plane. To make it even better, FePd also helped the phase-transformation of Co2MnSi to ordered B2 known to have high spin polarization, which makes the L10 FePd/B2 Co2MnSi bilayer promising for perpendicular-magnetic tunnel junction and improving both thermal stability and tunnel magnetoresistance.
Detection of discrete surface charge dynamics in GaAs-based nanowire through metal-tip-induced current fluctuation
Authors: Sato Masaki , Yin Xiang , Kuroda Ryota , Kasai Seiya 
Published: December 2015

Abstract
We investigated the detection of discrete charge dynamics of an electron trap in a GaAs-based nanowire surface through current fluctuation induced by a metallic scanning probe tip. An equivalent circuit model indicated that the charge state in the surface strongly reflects the channel potential when the local surface potential is fixed by the metal tip, which suggests that random charging and discharging dynamics of the trap appears as random telegraph signal (RTS) noise in the nanowire current. Experimental demonstration of the concept was carried out using a GaAs-based nanowire and an atomic force microscope (AFM) system with a conductive tip. We observed the RTS noise in the drain current and superposition of the Lorentzian component in the noise spectrum when the metal tip was in contact with the nanowire surface at specific positions. The obtained results indicate the possibility of detecting charge dynamics of the individual surface trap in semiconductor devices.
Biodegradable and magnetic core–shell composite particle prepared by emulsion solvent diffusion method
Authors: Oka Chiemi , Ushimaru Kazunori , Horiishi Nanao , Tsuge Takeharu , Kitamoto Yoshitaka 
Published: December 2015

Abstract
The present paper describes optimization of preparation conditions of a core–shell composite particle, and its heat generation by alternating magnetic fields. The composite particles are prepared with a modified emulsion solvent diffusion method, which is combined with Pickering emulsion stabilized by magnetic nanoparticles. In this method, the magnetic nanoparticles act as an emulsifier, and its amount and size are crucial to morphology of the composite particles. The magnetic nanoparticles of 8–9 nm would be strongly adsorbed at a liquid–liquid interface rather than the larger nanoparticles. At the optimized concentration of the magnetic nanoparticle’s suspension for the preparation, small and uniform composite particles are obtained since the amount of the nanoparticles is enough to prevent coalescence of droplets during the formation of the composites. The heat generation by alternating magnetic fields emerged certainly. This result suggests the composite particles have a property as a heat-generating carrier for hyperthermia treatment.
Composite of magnetic drug carriers with thermo-responsive polymer for controlled drug release
Authors: Liu Jia , Kitamoto Yoshitaka 
Published: December 2015

Abstract
The present paper describes organic/inorganic composite nanoparticles (CNPs) with a thermal response for biomedical applications. The composite nanoparticles are composed of a thermo-responsive polymer shell of hydroxypropyl cellulose (HPC) and a magnetic FeO
x
/silica core that exhibits a heat-generation capability against alternating magnetic fields. The heat-generation capability of the FeO
x
core was improved by modifying the synthesis process of the NPs to oxidize nonmagnetic FeO to magnetic Fe3O4. The HPC shell is observed by transmission electron microscopy after coating FeO
x
/silica NPs with HPC; the coating is confirmed by the increase of the hydrodynamic size of NPs and the weight loss with thermogravimetry. The FeO
x
/silica/HPC composite NPs exhibit a thermal response, which is confirmed by the temperature-dependent hydrodynamic size of the NPs. These results indicate that the thermo-responsive FeO
x
/silica/HPC composite particles have a potential as a drug carrier with a capability of controlled release.
Pulmonary Vein Isolation vs Sham Intervention in Symptomatic Atrial Fibrillation
Authors: Dulai Rajdip , Sulke Neil , Freemantle Nick , Lambiase Pier D. , Farwell David , Srinivasan Neil T. , Tan Stuart , Patel Nikhil , Graham Adam , Veasey Rick A. 
Published: September 2024

ImportanceThere are concerns that pulmonary vein isolation for atrial fibrillation may have a profound placebo effect, but no double-blind randomized clinical trials have been conducted.ObjectiveTo determine whether pulmonary vein isolation is more effective than a sham procedure for improving outcomes in atrial fibrillation.Design, Setting, and ParticipantsDouble-blind randomized clinical trial conducted at 2 tertiary centers in the UK between January 2020 and March 2024 among patients with symptomatic paroxysmal or persistent atrial fibrillation. Major exclusion criteria included long-standing persistent atrial fibrillation, prior left atrium ablation, other arrhythmias requiring ablative therapy, a left atrium of 5.5 cm or larger, and ejection fraction of less than 35%.InterventionParticipants were randomly assigned to receive pulmonary vein isolation with cryoablation (n = 64) or a sham procedure with phrenic nerve pacing (n = 62).Main Outcomes and MeasuresThe primary end point was atrial fibrillation burden at 6 months, excluding a 3-month blanking period. Secondary outcomes included quality-of-life measures, time to events, and safety. Atrial fibrillation burden was measured by an implantable loop recorder.ResultsA total of 126 participants were randomized (mean age, 66.8 years; 89 men [70.63%]; 20.63% with paroxysmal atrial fibrillation). The absolute mean atrial fibrillation burden change from baseline to 6 months was 60.31% in the ablation group and 35.0% in the sham group (geometric mean difference, 0.25; 95% CI, 0.15-0.42; P &amp;lt; .001). The estimated difference in the overall Atrial Fibrillation Effect on Quality of Life score at 6 months, favoring catheter ablation, was 18.39 points (95% CI, 11.48-25.30 points). The Short Form 36 general health score also improved substantially more with ablation, with an estimated difference of 9.27 points at 6 months (95% CI, 3.78-14.76 points).Conclusions and RelevancePulmonary vein isolation resulted in a statistically significant and clinically important decrease in atrial fibrillation burden at 6 months, with substantial improvements in symptoms and quality of life, compared with a sham procedure.Trial RegistrationClinicalTrials.gov Identifier: NCT04272762
Universal Genetic Testing for Newly Diagnosed Invasive Breast Cancer
Authors: Rezoug Zoulikha , Totten Stephanie P. , Szlachtycz David , Atayan Adrienne , Mohler Kristen , Albert Sophie , Feng Leila , Lemieux Anglin Brianna , Shen Zhen , Jimenez Daniel , Hamel Nancy , Meti Nicholas , Esfahani Khashayar , Boileau Jean-François , Prakash Ipshita , Basik Mark , Meterissian Sarkis , Tremblay Francine , Fleiszer David , Anderson Dawn , Chong George , Wong Stephanie M. , Foulkes William D. 
Published: September 2024

ImportanceBetween 5% and 10% of breast cancer cases are associated with an inherited germline pathogenic or likely pathogenic variant (GPV) in a breast cancer susceptibility gene (BCSG), which could alter local and systemic therapy recommendations. Traditional genetic testing criteria misses a proportion of these cases.ObjectiveTo evaluate the prevalence and clinicopathological associations of GPVs in 2 groups of BCSGs among an ethnically diverse cohort of women with newly diagnosed breast cancer.Design, Setting, and ParticipantsThis cross-sectional study, conducted at 3 Montreal hospitals between September 2019 and April 2022, offered universal genetic counseling and testing to all women with a first diagnosis of invasive breast cancer. Women were offered an obligatory primary panel of BRCA1, BRCA2, and PALB2 (B1B2P2) and an optional secondary panel of 14 additional BCSGs. Eligible participants were women 18 years of age or older who received a diagnosis of a first primary invasive breast cancer not more than 6 months before the time of referral to the study. Data were analyzed from November 2023 to June 2024.ResultsOf 1017 referred patients, 805 were eligible and offered genetic counseling and testing, and 729 of those 805 (90.6%) consented to be tested. The median age at breast cancer diagnosis was 53 years (range, 23-91 years), and 65.4% were White and of European ancestry. Fifty-four GPVs were identified in 53 patients (7.3%), including 39 patients (5.3%) with B1B2P2 and 15 patients (2.1%) with 6 of the 14 secondary panel BCSGs (ATM, BARD1, BRIP1, CHEK2, RAD51D, and STK11). On multivariable analysis, clinical factors independently associated with B1B2P2-positive status included being younger than 40 years of age at diagnosis (odds ratio [OR], 6.83; 95% CI, 2.22-20.90), triple-negative breast cancer (OR, 3.19; 95% CI, 1.20-8.43), high grade disease (OR, 1.68; 95% CI, 1.05-2.70), and family history of ovarian cancer (OR, 9.75; 95% CI, 2.65-35.85). Of 39 B1B2P2-positive patients, 13 (33.3%) were eligible for poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors.Conclusions and RelevanceIn this cross-sectional universal genetic testing study of women with newly diagnosed invasive breast cancer, the prevalence of GPVs was 7.3%, with 5.3% of patients testing positive for B1B2P2. Among B1B2P2-women women, one-third were eligible for PARP inhibitors.
SOX‐5 Transcription Factor: a Novel Psoriatic Autoantigen Preferentially Found in Women
Authors: Orbai Ana‐Maria , Fiorentino David , Perin Jamie , Darrah Erika , Yang Qingyuan , Gutierrez‐Alamillo Laura , Bingham Clifton O. , Petri Michelle , Rosen Antony , Casciola‐Rosen Livia 
Published: September 2024

ObjectiveAdaptive immunity mediates psoriatic disease pathogenesis. We aimed to identify novel psoriatic autoantigens and their phenotypic associations in deeply characterized patient cohorts.MethodsSera from psoriatic arthritis (PsA) patients were used for autoantibody discovery. Immunoprecipitations performed with cell lysates were on‐bead digested, and autoantigens were identified by mass spectrometry. Prevalence and clinical features associated with anti–SRY‐Box transcription factor‐D (SOX‐D) antibodies were determined by screening discovery cohorts of patients with PsA (n = 135), patients with psoriasis without PsA (n = 24), and healthy controls (n = 41). A PsA validation cohort (n = 325) and disease control samples of individuals with rheumatoid arthritis (RA; n = 66) and systemic lupus erythematosus (SLE, n = 66) were assayed for anti‐SOX5 antibodies. Disease characteristics were compared by antibody status. Longitudinal data were analyzed using linear mixed‐effects models with patient‐specific intercept to ascertain associations. We also tested PsA sera for the recently described anti–ADAMTS‐L5 autoantibody in PsA.ResultsThe novel autoantigens identified were SOX‐D transcription factors, with SOX‐5 being the focus of this analysis. Anti‐SOX5 antibodies were present in 8.9% (12 of 135) and 4.3% (14 of 323) of patients in the PsA discovery and validation cohorts, respectively, 12.5% of patients (3 of 24) in the psoriasis group, 2.4% (1 of 41) of healthy controls, and 7.6% (5 of 66) each of patients in the RA and SLE groups. Anti‐SOX5 were associated with female sex in both PsA cohorts (discovery: 15.7% women, 2.6% men, P = 0.006; validation: 6.3% women, 1.4% men, P = 0.049). In a longitudinal analysis adjusted for sex, anti‐SOX5 associated with biologic disease‐modifying antirheumatic drug treatment (95% vs 61%; P = 0.001; n = 96) and with differences in estimated treatment effects by mechanism of action. Anti–ADAMTS‐L5 autoantibodies were identified in 8 of 124 patients (6.5%) in the PsA group.ConclusionSOX‐D transcription factors are novel psoriatic autoantigens. Anti‐SOX5 antibodies were preferentially found in women with PsA and associated with specific clinical and treatment characteristics, suggesting that anti‐SOX5 antibodies may identify mechanistic subgroups. We independently validated anti–ADAMTS‐L5 autoantibodies in PsA.
Microchip Based Isolation and Drug Delivery of Patient‐Derived Extracellular Vesicles Against Their Homologous Tumor
Authors: Ge Ke , Ren Yongan , Hong Zichen , Mao Zhenjun , Yao Bo , Ye Kai , Jia Changku 
Published: September 2024

AbstractExtracellular vesicles (EVs) have demonstrated significant potential in drug delivery and anti‐tumor therapy. Despite this promising strategy, challenges such as specific targeting, EVs purification persist. In this study, a personalized nanodrug delivery platform using patient‐derived tumor EVs (PT‐EVs) based on a microchip is presented. The microchip integrates multiple functions, including capture, enrichment, drug loading, and elution of PT‐EVs. The isolation and drug‐carrying procedures are completed within a 12 h timeframe, achieving a recovery rate of 65%, significantly surpassing the conventional ultracentrifuge (UC) method. Furthermore, PT‐EVs derived from patient tumor models are first utilized as natural drug carriers, capitalizing on their inherent homing ability to precisely target homologous tumors. Lenvatinib and doxorubicin (DOX), two commonly utilized drugs in the clinical treatment of hepatocellular carcinoma (HCC), are loaded into PT‐EVs and delivered to a matched in vitro tumor model that recapitulates original tumors for drug susceptibility testing. As is proven, PT‐EVs exhibit robust tumor cell targeting and efficient receptor‐mediated cellular uptake, and the efficacy of chemotherapeutic drugs is improved significantly. These results suggest that this platform could be a valuable tool for efficient isolation of PT‐EVs and personalized drug customization, particularly when working with limited clinical samples, thus supporting personalized and precision medicine.
Transition Metal Complexes as Therapeutics: A New Frontier in Combatting Neurodegenerative Disorders through Protein Aggregation Modulation
Authors: Navale Govinda R. , Ahmed Imtiaz , Lim Mi Hee , Ghosh Kaushik 
Published: September 2024

AbstractNeurodegenerative disorders (NDDs) are a class of debilitating diseases that progressively impair the protein structure and result in neurological dysfunction in the nervous system. Among these disorders, Alzheimer's disease (AD), prion diseases such as Creutzfeldt‐Jakob disease (CJD), and Parkinson's disease (PD) are caused by protein misfolding and aggregation at the cellular level. In recent years, transition metal complexes have gained significant attention for their potential applications in diagnosing, imaging, and curing these NDDs. These complexes have intriguing possibilities as therapeutics due to their diverse ligand systems and chemical properties and can interact with biological systems with minimal detrimental effects. This review focuses on the recent progress in transition metal therapeutics as a new era of hope in the battle against AD, CJD, and PD by modulating protein aggregation in vitro and in vivo. It may shed revolutionary insights into unlocking new opportunities for researchers to develop metal‐based drugs to combat NDDs.
Decorating Delivery Vehicles Using Hyaluronic Acid Oligosaccharides Enables Active Targeting Toward Cancer and Minimizes Adverse Effect of Chemotherapeutics
Authors: Jia Weibin , Li Runrun , Zou Fengjuan , Li Min , Weng Hongjuan , Shen Qianqian , Qi Guozhen , Zhou Ruipiao , Shi Yikang , Gu Guofeng , Wang Fengshan , Chen Zonggang 
Published: September 2024

AbstractThe major drawback of conventional chemotherapeutic treatment is the non‐specificity or inability to ascertain and target cancerous cells directly. In this study, an active targeting strategy that is poised to carry the anticancer agents to the desired sites for therapeutic action while avoiding toxicity to normal organs is provided. The active targeting of delivery vehicles is achieved by ligand‐receptor interactions, in particular the specific binding between hyaluronic acid oligosaccharides (oHAs) and CD44 receptors. This study first prepares oHAs by the size‐exclusion chromatography and utilizes them to decorate chitosan (CTS) as basic materials (oHAs‐CTS) for drug delivery, then fabricates oHAs‐CTS into micro/nanoscale carriers to encapsulate agents for cancer chemotherapy. The oHAs‐CTS micro/nanocarriers exhibit high drug encapsulation efficiency (58–87%), and the drug releases present a sustained behavior. Notably, oHAs‐CTS delivery vehicles display an enhanced active targeting toward cancers and alleviate the cytotoxic effects on normal cells. Additionally, in vivo results show that drug‐laden oHAs‐CTS nanocarriers demonstrate a significant inhibitory effect on 4 T1 tumors without any toxicity to the major organs. Taken together, the findings highlight the potential of oHAs‐CTS micro/nanospheres as delivery vehicles with enhanced active targeted capability toward cancers and minimized adverse effects of chemotherapeutic agents for cancer treatment.
Three‐Component Synthesis of Substituted Azepines by Gold/Magnesium Orthogonal‐Relay Catalysis
Authors: Kosuge Shuto , Kiraku Yoshihiro , Tsuge Kiyoshi , Sugimoto Kenji , Matsuya Yuji 
Published: September 2024

AbstractA three‐component one‐pot synthesis of substituted azepines was realized by gold/magnesium orthogonal relay catalysis. The one‐pot synthesis involves simply mixing and heating propiolates, imines, and activated cyclopropanes to initiate a gold‐catalyzed aza‐enyne metathesis between propiolates and imines, followed by a magnesium‐catalyzed [4+3] cycloaddition reaction of the resultant 1‐azabutadienes and the cyclopropanes, yielding substituted azepines. The substituted azepines including 22 derivatives could be successfully prepared in good to excellent yield (61–95%). The reaction was also conducted on one‐gram scale.