bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transcending Carbon Life: A Vision for Sustainable Future
Authors: Aghanouri Reza 
Published: September 2024

Abstract
The concept of “transcending carbon life” proposes a shift from traditional carbon-based biological existence to a data-centric, digital form of life. This is driven by the need to address escalating environmental crises caused by carbon-intensive human activities. The main challenges of carbon-based life include climate change, resource depletion, and environmental degradation. “Transcending Carbon Life” aims to address these issues by leveraging advancements in digital technologies and data science. The core principles involve digital existence, where life forms could be replicated and preserved as data, and data-centric living, emphasizing the use of high-quality data and synthetic data to drive decision-making and innovation. Potential benefits include improved environmental sustainability, enhanced medical research and life extension, and better global connectivity and knowledge sharing. However, significant technological development, ethical considerations, and infrastructure challenges need to be addressed to make this vision a reality. Overall, “transcending carbon life” represents a transformative approach to ensuring the long-term survival, superior intelligence governance, and ecological balance of all living entities on earth.
Detection of Vibrio cholerae as a Potential Microbiological Hazard from Water Samples Used for Cleaning Purpose of Pani-puri Serving Plates in Dhaka City, Bangladesh
Authors: Momo Maisha Farzana , Alam Seemi Tasnim , Monir Sawda Binte , Shayem H. M. Abu , Sultana Raquiba , Tisha Rowson Habiba , Sultana Sadiya , Islam Jahidul , Uddin Md. Aftab 
Published: September 2024

Abstract

BACKGROUND:
Cholera remains a significant public health concern, particularly in endemic regions like Bangladesh. This study aimed to assess the prevalence and characteristics of Vibrio cholerae contamination in pani-puri plate wash water in Dhaka city, employing biochemical, microscopic, and antibiotic resistance analyses.

METHODS:
A total of 20 pani-puri plate wash water samples were collected from various locations in Dhaka between August 2023 and October 2023. The samples were analyzed at the Department of Microbiology, Stamford University Bangladesh.

RESULTS:

V. cholerae was found to be highly prevalent, especially in crowded urban areas. Biochemical tests confirmed the identity of the isolates as V. cholerae. Antibiotic susceptibility testing revealed concerning resistance patterns, with 100% resistance to commonly used drugs such as meropenem and ampicillin. In addition, resistance to cefixime, nalidixic acid, and chloramphenicol was observed, emphasizing the need for alternative treatment options.

CONCLUSION:
These findings highlight the significance of ongoing monitoring of V. cholerae populations for virulence factors and changes in antibiotic resistance to inform public health interventions and cholera control measures. The study underscores the importance of strict hygienic standards in the preparation of street food, particularly in endemic locations such as Dhaka, Bangladesh, to reduce the risk of waterborne diseases. Continuous surveillance for drug resistance and microbiological contamination is crucial for effective cholera treatment and prevention.
Thalassemia Disorders: A Scoping Insight toward Management and Patient Care Prospects
Authors: Al-Taie Anmar , Ürek Ammar , Kayas Hala , Tahir Hassan 
Published: September 2024

Abstract
Thalassemia (TH) is a group of inherited autosomal recessive blood disorders that are among the most common genetic diseases in the world and originate in the Mediterranean. The condition is caused by a number of genetic defects, and depending on the severity of the disease, untreated individuals may develop clinical complications such as skeletal deformities and growth retardation, splenomegaly, extramedullary hematopoiesis, heart failure, and endocrine complications. Based on a growing understanding of the sequential pathophysiological events, this study provides a scoping review of currently applied treatment, new attractive and potentially novel therapies that are starting to immerge for TH. Furthermore, because this genetic disorder necessitates long-term care, preventing the homozygous state is a critical tool in management alongside preventative measures toward patient care.
CEBPB dampens the cuproptosis sensitivity of colorectal cancer cells by facilitating the PI3K/AKT/mTOR signaling pathway
Authors: Huang Tianchen , Zhang Yong , Wu Yachao , Han Xiaodong , Li Lei , Guo Zhipeng , Li Kan , Xin Yanshan , Wang Weijie 
Published: September 2024

Abstract

Background:
Cuproptosis is a novel pathway that differs from other forms of cell death and has been confirmed to be applicable for predicting tumor prognosis and clinical treatment response. However, the mechanism underlying the resistance of colorectal cancer (CRC) to cuproptosis at the molecular level has not been elucidated.

Methods:
Using bioinformatics analysis, the expression of CCAAT/enhancer-binding protein beta (CEBPB) in CRC tissues and its enrichment in biological processes were detected. Quantitative reverse transcription polymerase chain reaction and western blotting (WB) were employed to test the expression of CEBPB in CRC cells. WB was utilized to assess the levels of proteins related to cuproptosis and the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway. The MTT assay was used to test cell viability. Cell proliferation was assessed by a colony formation assay. Transwell assays were used to measure cell migration and invasion ability. DLAT-aggregate formation was determined by immunofluorescence.

Results:
CEBPB was highly upregulated in CRC cells to enhance cell viability, proliferation, migration, and invasion. CEBPB was strongly implicated in copper ion homeostasis and the mTOR signaling pathway in CRC. In a CRC cuproptosis cell model, rescue experiments revealed that a PI3K/AKT/mTOR pathway inhibitor attenuated the promoting effect of CEBPB overexpression on the PI3K/AKT/mTOR pathway and rescued the sensitivity of CRC to cuproptosis.

Conclusion:
This work demonstrated that CEBPB can activate the PI3K/AKT/mTOR signaling pathway, thereby decreasing the sensitivity of CRC to cuproptosis. These data suggested that targeting CEBPB or the PI3K/AKT/mTOR pathway may enhance the sensitivity of CRC patients to cuproptosis, providing a combined therapeutic strategy for cuproptosis-induced therapy.
A pattern of presentation and management of lip cancer in a tertiary institution in Northwestern Nigeria: A retrospective study
Authors: Bala Mujtaba , Ibikunle Adebayo Aremu , Braimah Ramat Oyebunmi , Taiwo Abdulrazaq Olanrewaju , Yabo Sufiyanu Umar , Aliyu Bashar Muhammad , Abdulhakeem Abdullateef , Olayemi Lukman A. , Abubakar Sadeeq Fawa , Bawa Anas Tsafe 
Published: September 2024

Introduction:
The lips just like any other part of the body could be affected ny myriads of diseases including infection and neoplasm. Surgical management of lip cancer is often challenging in both reconstructive options and outcomes.

Aims:
This study aimed to assess the pattern of presentation and management of lip cancer in Usmanu Danfodiyo University Teaching Hospital Sokoto.

Materials and Methods:
This was a retrospective study of cases of lip cancer managed at the Department of Dental and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital Sokoto, northern Nigeria, over 9 years. Data collected included patients’ demographics, lip involved, treatment given, and the treatment outcomes data were analyzed using IBM SPSS version 25.

Results:
Of the 47 cases in the study, 31 (66.0%) were male and 16 (34.0%) were female and the majority of them were aged over 50 years. The range was 43–76 years with a mean of ± standard deviation of 55.06 ± 8.9. There were no statistically significant differences in either age or gender. The lower lip was involved in 41 (87.2%), whereas the upper lip was involved in 6 (12.8%) cases. Squamous cell carcinoma (SCC) constituted the majority at 42 (89.4%), which were mostly well differentiated. Of the 6 cases of the lower lip, 4 cases were basal cell carcinoma, 1 case was SCC, and the remaining 1 case was sebaceous carcinoma. A total of 38 (80.9%) patients were surgically treated, and the remaining 9 (19.1%), were referred to the oncology department. Of the various options available in the literature for lip reconstruction after tumor excision, nasolabial flap 17 (44.7%) was the most frequently used in our cases, and the outcome of all the surgeries was found satisfactory.

Conclusion:
Lip cancer is a relatively common cancer in the orofacial region, and the majority is SCC. All the cases of basal cell carcinoma occur in the upper lip. Several options are available for the reconstruction of the lip defect after resection, with the nasolabial flap being a versatile option.
Dental anxiety, pain, and quality of life among exodontia patients: A cross-sectional study
Authors: Famurewa Bamidele A. , Emmanuel Abimbola A. , Alade Omolola T. , Adedigba Michael A. 
Published: September 2024

Introduction:
There are few studies on dental anxiety (DA) among patients who are planned for routine dental extraction compared with a plethora of published reports on DA and oral health-related quality of life (OHRQoL) in patients undergoing third molar surgery.

Aim:
This study aims to investigate anxiety level, pain experience and OHRQoL of patients scheduled for routine exodontia at a Nigerian tertiary hospital.

Materials and Methods:
This was a cross-sectional study conducted at the Oral Surgery clinic of Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria from April to September 2019. DA, pain, and OHRQoL of participants were assessed using Corah’s DA Scale (DAS), Visual Analog Scale (VAS) and 14-item oral health impact profile (OHIP-14) questionnaire, respectively. Just before routine exodontia, the demographic variables of the participants were also recorded. Data were analyzed using R version 4.2.2.

Results and Discussion:
One hundred fifty-nine participants planned for routine exodontia of one or two permanent tooth/teeth with 41.7 ± 19.8 years mean age. The mean DAS score for the study population was 7.9 ± 3.6 (range: 4–18) with the proportion of dentally anxious patients (DAS score ≥13) being 15.1%. The majority (125; 78.6%) reported preexodontia dental pain VAS score of 4–10. Only 22.6% of the participants had their OHRQoL significantly impaired with OHIP-14 score of 29–56.

Conclusion:
The prevalence of DA among Nigerian adults scheduled for routine exodontia was 15.1%. At least seven in ten patients had moderate and severe dental pain, while one-fifth presented with significantly impaired OHRQoL.
Evaluation of nano-hydroxyapatite application on fluorosed and nonfluorosed dentinal surface: A scanning electron microscope study
Authors: Vandana Kharidhi Laxman , Aditya Vangara , Mahajan Neha 
Published: September 2024

Introduction:
Although there are many desensitizing medications on the market with promising results, their therapeutic advantages are sometimes fleeting or diminished over time since they might be gradually destroyed by consistent tooth brushing or ingestion of acidic beverages.

Aim:
In this scanning electron microscope study, an initial effort was made to evaluate and compare the dentinal changes that occurred after healthy fluorosed and nonfluorosed teeth were subjected to the application of 1% and 10% nano-hydroxyapatite (n-HAP) desensitizing agents.

Materials and Methods:
This study included 10 healthy fluorosed teeth and 10 nonfluorosed teeth with ages ranging from 20 to 40 years. Test Group 1 received 1% n-HAP desensitizing agent, whereas test Group 2 received 10% n-HAP formulation. Over 7 days, the dentin samples were brushed twice daily for 2 min. The samples were subsequently exposed to artificial saliva for 1 week. The diameter of the dentinal tubules was measured using ImageJ, and the dentinal tubules were manually counted using Adobe Photoshop CS3.

Results and Discussion:
When comparing the quantity and percentage of completely and partially occluded dentinal tubules in teeth treated with 1% and 10% n-HAP desensitizing agents, no statistically significant differences between fluorosed and nonfluorosed teeth were found (P = 0.94). Furthermore, the mean diameter of partially occluded dentinal tubules in fluorosed and nonfluorosed teeth was statistically significant (P = 0.00).

Conclusion:
When n-HAP toothpaste was used, dentinal tubules were occluded. Data from this trial and other studies indicate the therapeutic efficacy of the n-HAP dentifrice, suggesting that it could be utilized to reduce dentin hypersensitivity.
Robotically assisted dental implant surgery
Authors: Fatani Bader 
Published: September 2024

Introduction:
The most critical factor affecting implant treatment outcome is implant placement accuracy which includes the depth, angle, and position of the implant within the bone. Previousstudieshavediscussedtheapplicationoftheroboticsyst eminthesurgicalfield. However, few of these studies addressed the use of the computerized system in dental implant surgery.

Aim:
This study aims to review recent updates and guidelines discussing robotic-assisted implant surgery.

Materials and methods:
Major scientific databases were searched during 2021-2022.97 articles were collected and was screened using inclusion criteria. A total of 18 articles were used for this review.

Results and Discussion:
Robotically assisted dental implant surgery is a form of surgical guidance that provide precise advice for implant treatment planning, preparation, and placement of dental implants, as well as accurate visual navigation. The advantages of robotic-assisted implant surgery include greater efficiency, sustained precision, flexibility, and increased stability.

Conclusion:
The combination of the robot's stabilization with the surgeon's experience is considered the standard of treatment during the placement of dental implants. Thus, a surgeon–robot collaboration system should be considered for a bettertreatmentoutcome.
Permanent teeth loss
Authors: Braimah Ramat Oyebunmi , Ali-Alsuliman Dawood , Sharma Harit Kanwar , Taiwo Abdulrazaq O. , Ibikunle Adebayo Aremu , Alsalah Yahyah , Makrami Reham , Alwalah Abdullah S. , Alajam Mohammed S. , Alalharith Abdullrahman Saeed 
Published: September 2024

Introduction:
Tooth loss is a worldwide public health concern of huge proportion. Problems associated with permanent tooth loss are enormous.

Aim:
This study aims to investigate the major reasons and patterns of permanent tooth extraction in a government referral dental center.

Materials and Methods:
This retrospective study was conducted on patients who had intra-alveolar extraction of teeth in our facility between January 2016 and December 2020. Sociodemographic data and type of tooth extracted were recorded. Reasons for extraction were classified into the following: caries, failed root canal treatment, failed restoration, periodontitis, prosthodontic, orthodontic, trauma, and over-eruption. Data were stored and analyzed with SPSS for MOS, Version 20.0.

Results and Discussion:
A total of 8065 (3248, 0.3%) males and 4817 (59.3%, females) patients presented for teeth extraction during the study period with 11,746 extractions done, giving an average of 1.5 extractions per individual. The age range of 11–102 years with a mean (±standard deviation) of 36.0 (16.6) was observed. The majority of the patients were in the age groups of 21–30 years (1992 (24.7%), then 31–40 years (1773 (22.0%). Caries and its sequelae accounted for the main reasons for tooth mortality. In the mandible, a total of 5321 (45.3%), while in the maxilla, a total of 6425 (54.7%) teeth were extracted. Molars were the most extracted tooth in both jaws (3485 (29.7%))

Conclusions:
The current study found that dental caries, and its sequelae, was the main reason for tooth extraction in a Saudi subpopulation, Najran. Molars were the most commonly extracted teeth.
Successful rehabilitation of a child patient with ankyloglossia using the diode laser of wavelength 808 nm and speech therapy
Authors: Khan Mohammad Kamran , Jindal Mahendra Kumar 
Published: September 2024

Abstract
Ankyloglossia is an abnormal congenital condition of the tongue characterized by abnormal attachment of lingual frenum or shorter lingual frenulum. Although various conventional surgical modalities and lasers for frenectomy has been described in literature, only few articles have been reported in the existing literature regarding the diode laser of 808 nm wavelength for frenectomy procedure in pediatric patient. Hence, the current article describes the clinical case report of successful and effective treatment of ankyloglossia using soft-tissue diode laser of 808 nm wavelength with minimally invasive dentistry approach in a 10-year-old male pediatric patient. In addition, the tongue-tie was clinically evaluated using the Hazelbaker Assessment Tool for Lingual Frenulum Function. Diode lasers can be used as a safe alternative surgical tool for managing tongue-tie with minimally invasive dentistry approach and also for alleviating the dental anxiety in pediatric patients.
Prosthetic rehabilitation of acquired maxillary defect secondary to mucormycosis with magnet-retained two-part prosthesis
Authors: Rathee Manu , Wakure Poonam , Malik Sanju , Singh Sandeep , Chahal Sujata , Divakar S. 
Published: September 2024

Abstract
Mucormycosis has recently become more common in India, with COVID-19 patients being the most affected. Pulmonary, gastrointestinal, disseminated, or rhinocerebral infections have various forms of mucormycosis. The most prevalent type is rhinocerebral, which affects the maxilla, nose, sinuses, and brain. A total or partial maxillectomy has an impact on a patient's cosmetic, functional, and psychological well-being. To replace not only missing teeth but also lost soft tissues and bone, such as the hard palate and alveolar ridges, a maxillofacial prosthodontist must overcome numerous obstacles. For the rehabilitation of such deformities, prosthetic rehabilitation has become the preferred option. Magnets are an efficient technique to provide retention, quality, and consistency in a system. This clinical report describes the prosthetic rehabilitation of an acquired maxillary defect secondary to mucormycosis with a magnet-retained two-part prosthesis.
Brown's tumor of mandible as a manifestation of primary hyperparathyroidism
Authors: Seraj Samia , Aggarwal Ashish , Upadhyay Nitin , Agarwal Nupur , Vishnurao Sowmya Gujjar , Rathore Ankit Singh 
Published: September 2024

Abstract
Hypercalcemia and increased or abnormal serum levels of parathyroid hormone are indicators of primary hyperparathyroidism (HPT). Brown tumor of bone is a rare nonneoplastic lesion that arises due to abnormal bone metabolism caused by HPT. The reported prevalence of brown tumor is 0.1%. In today's world, however, skeletal illness caused by primary HPT is quite rare. Patient consent was obtained. Here, we present a rare case of bony lytic lesion in the mandible that raised suspicion of giant cell lesion, compelling further investigations. The patient underwent blood investigations which revealed hypercalcemia. Ultrasonography revealed a hypoechoic mass on the left inferior thyroid lobe. An incisional biopsy was done which revealed hemorrhagic fibrovascular connective tissue in a background of multinucleated giant cells; the mandibular lesion was classified as a giant cell lesion. A final diagnosis of Brown tumor of the mandible was made based on the investigations. The left parathyroidectomy was done. Curettage of the mandibular lesion was done surgically. The patient was on follow-up for 6 months and showed no signs of recurrence. Although Brown tumor of mandible is a rare lesion, it should be considered a differential diagnosis for osteolytic lesions of the jaw. Early diagnosis can help to prevent late outcomes of the disease.
Evaluation of alveolar bone changes of jaws in periodontitis patients with and without dental fluorosis using cone-beam computed tomography
Authors: Vandana Kharidhi Laxman , Thushara Mohanan , Shivaprasad S. 
Published: September 2024

ABSTRACT

Background:
The periodontal management in patients affected by dental fluorosis and its effect on jawbone quality presents a blind spot due to a lack of knowledge.

Aim:
The aim of the study was to determine how dental fluorosis affects the periodontium in terms of cortical plate thickness, trabecular pattern, and bone density (BD), and the study compares patients with and without dental fluorosis who have periodontitis.

Materials and Methods:
There were a total of 30 patients in each of both groups, nonfluorosed periodontitis and fluorosed periodontitis. The age group of 35–50 years belonged to both sexes. The clinical and radiographic characteristics (BD, trabecular pattern, and cortical plate thickness) of each group were assessed and evaluated.

Results:
Thicker buccal cortical plate was found in the fluorosed healthy group (1.1 mm). The BD of the fluorosed diseased group was found to be greater than that of the nonfluorosed diseased group. Significant differences between several trabecular patterns were visible in the trabecular pattern (P = 0.02). Nevertheless, both healthy (63%) and diseased (80%) fluorosed sites exhibited the most significant levels of thick dense pattern.

Conclusion:
The fluorosed and nonfluorosed groups had significantly different bone quality, according to cone-beam computed tomography (CBCT) results.
Factors associated with undertriage of trauma patients at level 1 trauma center
Authors: Al Babtain Ibrahim , Alnasser Mohammed , Dohaim Abrar Bin , Alomar Sahar Hammad 
Published: September 2024

Background:
Applying American College of Surgeons Trauma Team Activation (TTA) criteria could improve trauma system outcomes and minimize both overtriage and undertriage of trauma patients. However, a percentage of trauma patients might slip through the system and become undertriaged.

Objective:
The objective of the study is to investigate factors related to undertriage of trauma patients at level 1 trauma center.

Design:
This was a retrospective cohort study.

Setting and Subjects:
We included all trauma patients at a level 1 trauma center from January 1, 2016, to December 31, 2019.

Methods and Main Outcome Measures:
We compared those who received TTA after 5 min of their arrival to emergency department (ED) (undertriaged cohort) to those who received no TTA (properly triaged cohort) in terms of demographic, anatomical, and physiological factors as well as injury severity assessment.

Results:
A total of 3740 trauma patients were included; 3330 (89%) were appropriately triaged and needed no TTA while 410 (10.9%) were undertriaged. In multivariate logistic regression model, the following factors were significantly associated with undertriage: arriving to ED in weekends (odd ratio, 1.417, confidence interval [CI] 95%, 1.047–1.916), motorcycle accidents (odds ratio, 3.709, 95% CI, 1.422–9.671), pedestrian victims (odds ratio, 7.477, 95% CI, 3.048–18.341), heart rate <60 (odds ratio, 2.657, 95% CI, 1.083–6.522), systolic blood pressure 76–89 (odds ratio, 4.235, 95% CI, 1.596–11.235), and Glasgow coma scale 9–12 (odds ratio, 4.365, 95% CI, 2.747–6.936).

Conclusion:
This study displayed different factors predictive of delayed TTA. Recognizing these factors could improve patient outcomes.

Limitations:
Poor prehospital documentation and communication from emergency medical services and a large number of missing data.