bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue inhibitor of metalloproteinase (TIMP)-1 predicts failure of recovery of ejection fraction in acute heart failure with reduced ejection fraction
Authors: Tseng Chih-Hsueh , Huang Wei-Ming , Chang Hao-Chih , Yu Wen-Chung , Cheng Hao-Min , Chiang Chern-En , Chen Chen-Huan , Sung Shih-Hsien 
Published: September 2024

BackgroundHeart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinases-9 (MMP-9) in the recovery of left ventricular ejection fraction (LVEF).MethodsSubjects who presented with acute decompensated HF and reduced LVEF of ≤40% were eligible for this study. HFimpEF was defined by a follow-up LVEF >40% and a ≥10% improvement in LVEF. Overnight fasting N-terminal pro-brain natriuretic peptide (NT-proBNP), MMP-9 and TIMP-1 were measured within 24 hours before discharge. The study participants were followed for up to 5 years.ResultsAmong a total of 91 participants (70.1±16.2 years, baseline LVEF 28.9±7.6%), 19 (20.8%) of them had HFimpEF and 72 (79.2%) had persistent HFrEF at 6 months. The receiver operating characteristic curve analyses showed the area under curve measures for TIMP-1, MMP-9 and NT-proBNP in the prediction of HFimpEF were 0.69, 0.52 and 0.65, respectively. TIMP-1 was negatively correlated with HFimpEF as continuous variables (OR per 1-SD and 95% CI 0.99 (0.98 to 1.00)) and categorical variables (cut-off value 200.68 ng/mL, OR and 95% CI 0.16 (0.05 to 0.54)) after adjustment of confounding factors. During a mean follow-up duration 34.8 months, patients with HFimpEF will have better long-term survival than those with persistent HFrEF.ConclusionsIn subjects with decompensated HFrEF, TIMP-1, but not MMP-9 was associated with the reverse remodelling in LVEF. In addition, patients with HFimpEF would have better long-term survival.
TCTN1 Induces Fatty Acid Oxidation to Promote Melanoma Metastasis
Authors: Li Yinlam , Ming Ren , Zhang Tianyi , Gao Zixu , Wang Lu , Yang Yang , Shen Kangjie , Wei Chenlu , Zhu Yu , Li Jianrui , Zheng Shaoluan , Luo Zucheng , Ding Yiteng , Xuan Jiangying , Hu Qianrong , Yang Yanwen , Gu Jianying , Wei Chuanyuan 
Published: September 2024

Abstract
Metabolic reprogramming promotes and sustains multiple steps of melanoma metastasis. Identification of key regulators of metabolic reprogramming could lead to the development of treatments for preventing and treating metastatic melanoma. In this study, we identified that tectonic family member 1 (TCTN1) promotes melanoma metastasis by increasing fatty acid oxidation (FAO). In clinical melanoma samples, high expression of TCTN1 correlated with increased metastasis and shorter patient survival. Functionally, TCTN1 promoted melanoma invasion and migration in vitro and distant metastasis in vivo and induced a mesenchymal-like phenotype switch. Mechanistically, TCTN1 acted as a protein scaffold to promote the binding of HADHA and HADHB, subunits of the mitochondrial trifunctional protein complex, thus leading to FAO activation. TCTN1-mediated FAO activated the p38/MAPK signaling pathway in melanoma cells, promoting tumor epithelial–mesenchymal transition and stemness. Molecular docking indicated that the prostaglandin F receptor agonist fluprostenol can block HADHA/HADHB binding, which was confirmed experimentally. Treatment with fluprostenol was able to inhibit TCTN1-induced melanoma invasion and metastasis. Taken together, these findings elucidate the mechanism of TCTN1-mediated promotion of melanoma metastasis and support the potential application of fluprostenol for targeted therapy of metastatic melanoma.
Significance: TCTN1 activates fatty acid oxidation to induce melanoma mesenchymal phenotype switching and invasion by promoting the binding of the subunits of MTP, which can be targeted with fluprostenol to inhibit melanoma metastasis.
Identification of a Triangular Random Coefficient Model using a Correction Function
Authors: Carlson Alyssa 
Published: September 2024

Abstract
Previously, identification of triangular random coefficient models required a restriction on the dimension of the first stage heterogeneity or independence assumptions across the different sources of the heterogeneity. This note proposes a new identification strategy that does not rely on either of these restrictions but rather assumes conditional means have a conditional linear projection representation in order to construct “correction functions” to address endogeneity and gain identification of the average partial effect. This identification strategy allows for both continuous and discrete instruments. Finally, the proposed identification method is illustrated in estimating the returns to education.
Do Firms Value Court Enforceability of Noncompete Agreements? A Revealed Preference Approach
Authors: Hiraiwa Takuya , Lipsitz Michael , Starr Evan 
Published: September 2024

Abstract
Do firms value court enforceability of their workers' noncompete agreements (NCAs)? We leverage a 2020 Washington law that made NCAs unenforceable for workers earning less than $100k per year. If firms value the ability to enforce NCAs in court, then they should give just-below threshold workers raises to reach the threshold, resulting in excess mass just above the threshold. Using administrative data, we find no evidence of bunching, even where efficiency arguments are most plausible. A survey of Washington employment attorneys suggests little bunching because firms rarely need to enforce NCAs and because firms can use other, less restrictive alternatives.
The Divine Fish in the Unraveling Net: Riparian Futures and Ontological Collapse on the Mekong
Authors: Johnson Andrew Alan 
Published: September 2024

Abstract
On the Mekong, where hydropower and hybrid species have altered the river’s ecology, new sources of potential arise. As the yearly rise and fall of the river is punctuated by sporadic floods and ebbs depending on hydropower generation needs, fish and other species find their spawning and feeding cycles dramatically altered. In turn, they are replaced with new, hybrid species. In the social and religious realms, this material change gives rise to new spirits, and new networks of human and nonhuman forces. While many from the region turn to cash crops or migrant labor, others seek to make new connections by fishing this changed landscape. Through making kin with the new, monstrous river and its new denizens, through tying a new social net as old fishing nets fail, fishermen on the river reach toward new ways of belonging in altered social, ecological, and ontological worlds.
Youth Experiences With a Therapy Dog: Insights From a Therapeutic Mentoring Program
Authors: Stutey Diane M. , Rogalla Kylie , Jaime Michelle , Stark Cortny , Burr Becca , Wehrman Joseph , Denzler Nicole , Tapia Jose Luis 
Published: September 2024

Abstract
Dogs serve as companions with youth in a variety of therapeutic ways that help to increase positive mental health and wellness. In this study, a therapy dog, registered with the Alliance of Therapy Dogs (ATD), was introduced into a 12-week therapeutic youth mentoring program. Eleven youth, ages 11–15, had the opportunity to meet weekly with the therapy dog and completed the short-form State-Trait Anxiety Inventory (STAI) at the end of each visit. Observational data during weekly visits were collected and at the end of the 12 weeks, all youth participated in semi-structured individual interviews. Phenomenology was utilized to analyze data and a total of four themes emerged: Emotional Regulation, Connection and Support, Empathy and Vulnerability, and Presence. Results of this study suggested youth mentoring programs may benefit from partnering or integrating therapy dog services into pre-existing structures to help further support youth mental health.
Competing Models of Political Debate: Popular Representation in the Late Nineteenth-Century Meeting Hall
Authors: Petterson Anne 
Published: September 2024

Abstract
The high profile elections, parties, and petitions have acquired has placed public meetings at the lower end of the historians’ research agenda. The study of political meetings, however, offers an important addition to the diverse institutional landscape of the history of democracy. In the nineteenth century, meetings were regarded as an opportunity for political representation and a place where citizens and representatives of the people met. The meeting hall was a place where two political repertoires competed: Was the popular assembly a continuation of the political conventions of the streets, or should parliamentary rules of debate lead the way? This contribution demonstrates how the commitment to a fair and regulated debate was not only the effect of a top-down disciplinary strategy but was also actively demanded by participants in the meeting themselves. A case study of a public meeting on compulsory education in Amsterdam in 1889 makes clear how questions of access, regulation, and representation were continuously negotiated. As such, this contribution offers insight into nineteenth-century political representation and the participation of ordinary citizens in the political arena.
Introduction to the Supplement ‘Coming together to fight cancer: a series of policy briefs taking stock of the implementation of Europe’s Beating Cancer Plan in Belgium’
Authors: Delnord Marie , Schittecatte Gabrielle , Ghattas Jinane , Van Den Bulcke Marc 
Published: September 2024

AbstractCancer is one of the main public health challenges globally. In Europe, it is also the second leading cause of mortality and incidence is likely to increase from nearly 4 million cases per year in 2020 to over 5 million new cases per year by 2040. Recognizing the urgency of tackling the entire disease pathway and supporting European Union (EU) Member States (MS), the European Commission (EC) launched two major initiatives: Europe's Beating Cancer Plan (EBCP) and the Mission on Cancer (MoC). Belgium is one of the few EU MS that has set up a dedicated structure, known as the Belgian EBCP Mirror Group (MG), to support the implementation of the EU strategy against cancer. The MG is a large national stakeholder platform coordinated by the Cancer Centre at Sciensano (Belgian Institute of Health). This Supplement between includes eight policy briefs developed by the MG on the most pressing needs to address in the Belgian cancer field. The policy briefs take into account relevant interventions at national level as well as Belgium's participation in European projects as of 2021-2023.
Simultaneous low-frequency vibration isolation and energy harvesting via attachable metamaterials
Authors: Hyun Jaeyub , Jung Jaesoon , Park Jeongwon , Choi Wonjae , Kim Miso 
Published: September 2024

AbstractIn this study, we achieved energy localization and amplification of flexural vibrations by utilizing the defect mode of plate-attachable locally resonant metamaterials, thereby realizing compact and low-frequency vibration energy suppression and energy harvesting with enhanced output performance. We designed a cantilever-based metamaterial unit cell to induce local resonance inside a periodic supercell structure and form a bandgap within the targeted low-frequency range of 300–450 Hz. Subsequently, a defect area was created by removing some unit cells to break the periodicity inside the metamaterial, which led to the isolation and localization of the vibration energy. This localized vibration energy was simultaneously converted into electrical energy by a piezoelectric energy harvester coupled with a metamaterial inside the defect area. Consequently, a substantially enhanced energy harvesting output power was achieved at 360 Hz, which was 43-times higher than that of a bare plate without metamaterials. The proposed local resonant metamaterial offers a useful and multifunctional platform with the capability of vibration energy isolation and harvesting, while exhibiting easy handling via attachable designs that can be tailored in the low-frequency regime.
The digital age in retinal practice
Authors: Anguita Rodrigo , Ferro Desideri Lorenzo , Loewenstein Anat , Zinkernagel Martin 
Published: September 2024

AbstractThis editorial examines the transformative impact of the digital revolution on retinal practice, highlighting how technological advances are transforming patient care and pushing the boundaries of ophthalmology. It explores key areas of progress, including personalised medicine through big data, artificial intelligence and advanced imaging techniques; the role of telemedicine and home OCT in improving access and monitoring; advances in robotic surgery and 3D printing for vitreoretinal procedures; and the potential of large language models in patient education and communication. While highlighting the immense potential of these innovations, the editorial also addresses ethical considerations related to privacy and algorithmic bias. It emphasises the importance of multidisciplinary collaboration and maintaining a patient-centred approach in the digital age.
Acute pancreatitis occurring after COVID-19 vaccine: a case report and literature review
Authors: Kabaoglu Ceren , Ozisik Hatice , Kocabas Gokcen Unal , Yurekli Banu Sarer , Erdogan Mehmet 
Published: September 2024

Abstract
Background
Vaccines are uncommon causes of pancreatitis, and only a few case reports have described COVID-19 vaccine-related pancreatitis.

Case presentation
A 45-year-old male patient applied to the emergency department due to having serious abdominal pain. Pfizer-BioNTech COVID-19 vaccine, the last dose was administered 1 week ago. One week after vaccination, he experienced abdominal pain. Laboratory tests demonstrated elevated C-reactive protein, amylase, and lipase levels, and Ig G4 levels were normal. Abdominal computer tomography (CT) displayed acute edematous pancreatitis and peripancreatic inflammatory changes. The patient was diagnosed with acute pancreatitis due to the vaccine.

Conclusion
We should be aware that acute pancreatitis induced by the vaccine may occur a few days or weeks after the vaccine, especially in patients who have risk factors for acute pancreatitis.
Trajectories of daily antipsychotic use and weight gain in people hospitalized for the first episode of psychosis
Authors: Vochoskova Kristyna , McWhinney Sean R. , Fialova Marketa , Kolenic Marian , Spaniel Filip , Furstova Petra , Boron Petra , Okaji Yurai , Trancik Pavel , Hajek Tomas 
Published: September 2024

Abstract

Background
We need to better understand the risk factors and predictors of medication-related weight gain to improve metabolic health of individuals with schizophrenia. This study explores how trajectories of antipsychotic medication (AP) use impact body weight early in the course of schizophrenia.

Methods
We recruited 92 participants with first-episode psychosis (FEP, n = 92) during their first psychiatric hospitalization. We prospectively collected weight, body mass index (BMI), metabolic markers, and exact daily medication exposure during 6-week hospitalization. We quantified the trajectory of AP medication changes and AP polypharmacy using a novel approach based on meta-analytical ranking of medications and tested it as a predictor of weight gain together with traditional risk factors.

Results
Most people started treatment with risperidone (n = 57), followed by olanzapine (n = 29). Then, 48% of individuals remained on their first prescribed medication, while 33% of people remained on monotherapy. Almost half of the individuals (39/92) experienced escalation of medications, mostly switch to AP polypharmacy (90%). Only baseline BMI was a predictor of BMI change. Individuals in the top tercile of weight gain, compared to those in the bottom tercile, showed lower follow-up symptoms, a trend for longer prehospitalization antipsychotic treatment, and greater exposure to metabolically problematic medications.

Conclusions
Early in the course of illness, during inpatient treatment, baseline BMI is the strongest and earliest predictor of weight gain on APs and is a better predictor than type of medication, polypharmacy, or medication switches. Baseline BMI predicted weight change over a period of weeks, when other traditional predictors demonstrated a much smaller effect.
Ideal Family Size and Reproductive Orientations: An Exploration of Change Over Time in the United States
Authors: Behrman Julia A. 
Published: September 2024

Abstract
Drawing on more than 30 years of nationally representative microdata from the General Social Survey, this article comprehensively updates recent trends in ideal family size in the United States. It first documents stability in ideal family sizes between the mid-1980s and 2018, even in the face of a recent fertility decline. Next, the study adopts a latent class approach that identifies typologies of “reproductive orientations,” defined as multidimensional mental models of reproduction encompassing ideal family size, attitudes toward reproductive labor, and views on reproduction contexts. The findings indicate three distinct classes of reproductive orientations: Progressive Familialists, Conservative Familialists, and Blended Egalitarians. Further analyses suggest that the prevalence of these classes has changed over time and that class membership is associated with distinct patterns of childbearing and marriage. These findings deepen contemporary understandings of ideal family size in the United States and have broader implications for how demographers conceptualize and measure fertility preferences across diverse contexts.
Do Migrants Exhibit More Grit? A Research Note
Authors: White Michael J. , Myroniuk Tyler W. , Ginsburg Carren , Pheiffer Chantel 
Published: September 2024

Abstract
Strong expectations exist for the selectivity of migration along key demographic characteristics, such as age, sex, and education, which are often linked to social and economic drivers. Scholars acknowledge, however, that migratory behavior is also likely to be selective on characteristics that are less readily observable. This research note expands the list by examining “grit”—in other words, a measure of perseverance in the face of adversity. We test for a relationship between South African rural–urban migration, net of other standard covariates, and an established composite psychosocial measure of grit. We draw on two waves of survey data originating from a demographic surveillance platform but with respondents followed irrespective of their subsequent geographic mobility. Simple bivariate regressions suggest that grit is strongly associated with migration. Using multivariate models, we continue to detect a statistically significant association of migration with grit in the presence of controls. When the model is further refined to stratify by sex and separate geographic destinations, a sex differential emerges, with grit being more predictive for females. We conclude by suggesting that such findings should encourage broader inquiries that consider grit and other psychological characteristics, particularly investigations that might help further illuminate differentials by the experience of gender.
Actional Orientalism
Authors: Rivera Takeo 
Published: September 2024

Abstract
Through an analysis of the 2014 video game Dragon Age: Inquisition, this essay brings two contemporary problematics into dialogue—the neoliberal gamification of society and the logic of queer liberalism—to suggest that they converge upon a common, long-standing animus: the figure of the massified Oriental. The massified Oriental haunts Asianness, and retains East and Southwest Asia as its primary cultural referents, but the deterritorialization of Orientalism as an epistemic apparatus locates Orientalism in the realm of affect rather than geography. Thus, this paper proposes a heuristic of “actional Orientalism,” which draws attention to the procedural and discursive production of agency and the consequent narrative validation of that agency, contrasting agentic players against their objectified, thingified, and massified gameworlds. Whereas in Tara Fickle's “ludo-Orientalism,” wherein racialization is premised upon the otherness of the type of risk-taking and play, actional Orientalism draws on whether the racialized figure is capable of agency at all, finding within the Oriental the complete absence of the bounded, liberal, choosing subject. Dragon Age: Inquisition deploys actional Orientalism on full display, offering liberal transgender representation contingent upon acceptance of an individualist affect, requiring the full abjection of massified, Orientalized, queer others to enable this representation to survive.
Connecting to the Test: Investigating Gaps in E-Rate Subsidies for Internal Connectivity during California’s Transition to the Common Core State Standards
Authors: Hashim Ayesha K. 
Published: September 2024

abstract: Internet connectivity has become a critical resource for teaching and learning. The Common Core State Standards (CCSS) is a prime example, with schools expected to implement online assessments and use online resources for instruction. Yet there is little known about the extent to which local education agencies (LEAs) and schools are taking advantage of policies that subsidize spending on internet connectivity. This article assesses the gaps in LEA access to subsidies for internet connectivity provided under the Federal Communication Commission’s E-Rate program. This analysis is situated in California, an early-adopting state of the CCSS and one of the largest recipients of E-Rate subsidies. This article focuses on Category 2 subsidies earmarked for building high-density, wireless internal connectivity networks necessary for supporting multiuser, online testing in schools. Drawing on longitudinal data from the 2006–07 to 2016–17 school years, the growing LEA demand for Category 2 subsidies following California’s adoption of the CCSS in 2010–11 is documented. At the same time, there are notable gaps in LEA applications and funding for these subsides across attributes such as enrollment size, rural location, per-pupil revenues, prior success in funding, and for LEAs with lower enrollments of free and reduced-price lunch eligible students. In further analysis, this article shows that LEAs that were denied Category 2 subsidies incurred greater spending on non-capitalized equipment post-CCSS adoption and experienced a decline in ELA and math test scores that started even prior to the denial of funding for Category 2 subsidies, suggesting a somewhat challenging transition to the CCSS. However, unfunded LEAs did not perform as poorly in ELA and math once online testing for the CCSS started. This article discusses how the FCC’s Modernization Order has addressed funding gaps in E-Rate and considerations for future reforms to the program.