bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic protein–protein interaction mapping for clinically relevant human GPCRs
Authors: Sokolina Kate , Kittanakom Saranya , Snider Jamie , Kotlyar Max , Maurice Pascal , Gandía Jorge , Benleulmi‐Chaachoua Abla , Tadagaki Kenjiro , Oishi Atsuro , Wong Victoria , Malty Ramy H , Deineko Viktor , Aoki Hiroyuki , Amin Shahreen , Yao Zhong , Morató Xavier , Otasek David , Kobayashi Hiroyuki , Menendez Javier , Auerbach Daniel , Angers Stephane , Pržulj Natasa , Bouvier Michel , Babu Mohan , Ciruela Francisco , Jockers Ralf , Jurisica Igor , Stagljar Igor 
Published: March 2017

AbstractG‐protein‐coupled receptors (GPCRs) are the largest family of integral membrane receptors with key roles in regulating signaling pathways targeted by therapeutics, but are difficult to study using existing proteomics technologies due to their complex biochemical features. To obtain a global view of GPCR‐mediated signaling and to identify novel components of their pathways, we used a modified membrane yeast two‐hybrid (MYTH) approach and identified interacting partners for 48 selected full‐length human ligand‐unoccupied GPCRs in their native membrane environment. The resulting GPCR interactome connects 686 proteins by 987 unique interactions, including 299 membrane proteins involved in a diverse range of cellular functions. To demonstrate the biological relevance of the GPCR interactome, we validated novel interactions of the GPR37, serotonin 5‐HT4d, and adenosine ADORA2A receptors. Our data represent the first large‐scale interactome mapping for human GPCRs and provide a valuable resource for the analysis of signaling pathways involving this druggable family of integral membrane proteins.
Pneumococcal Vaccine Response After Exposure to Parasites in Utero, in Infancy, or Mid-Childhood
Authors: Nayakwadi Singer Monica , Heath Claire , Muinde Jackson , Gildengorin Virginia , Mutuku Francis M. , Vu David , Mukoko Dunstan , King Christopher L. , Malhotra Indu J. , King Charles H. , LaBeaud A. Desirée 
Published: March 2017

BACKGROUND AND OBJECTIVE:Streptococcus pneumoniae is a leading cause of mortality before age 5, but few studies examine details of childhood response to pneumococcal vaccine in less-developed settings. Although malnutrition, HIV, and concurrent infections can impair response, evidence suggests that chronic parasitic infections can also contribute to poor vaccination results. The objective of this study was to determine whether response to pneumococcal vaccine varied among children either exposed to parasitic infections in utero, previously infected in infancy, or infected at the time of immunization.METHODS:Children from a 2006 to 2010 maternal–infant cohort were eligible for the current study. Children were screened for malaria, schistosomiasis, filariasis, intestinal helminths, and protozoa. Data on in utero exposure and early life infections were linked, and baseline antipneumococcal immunoglobulin G levels and nasopharyngeal carrier status were determined. Participants received decavalent pneumococcal vaccine, and 4 weeks later, serology was repeated to assess vaccine response.RESULTS:A total of 281 children were included. Preimmunity was associated with greater postvaccination increments in anti–pneumococcal polysaccharide immunoglobulin G, especially serotypes 4, 7, 9, 18C, and 19. Present-day growth stunting was independently associated with weaker responses to 1, 4, 6B, 7, 9V, and 19. Previous exposure to Trichuris was associated with stronger responses to 1, 5, 6B, 7, 18C, and 23, but other parasite exposures were not consistently associated with response.CONCLUSIONS:In our cohort, hyporesponsiveness to pneumococcal conjugate vaccine was associated with growth stunting but not parasite exposure. Parasite-related vaccine response deficits identified before age 3 do not persist into later childhood.
An Educational Intervention to Support the Development of a Sense of Mastery of the Anticipated Paternal Role in Expectant Fathers: A Clinical Project
Authors: Bourget Mélanie , Héon Marjolaine , Aita Marilyn , Michaud Monique 
Published: March 2017

ABSTRACTThis article presents a clinical project of the development and evaluation of an educational intervention that aimed at promoting the development of a sense of mastery of the anticipated paternal role in soon-to-be fathers. The preventive role supplementation conceptual framework guided the development of 4 educational sessions that were delivered to 6 expectant fathers attending prenatal classes at a local community services center in Greater Montreal area. The participants highly appreciated the content and format of the educational intervention. They also expressed to have developed a sense of mastery of the anticipated paternal role. This interactive educational intervention, which focused on the specific needs of expectant fathers, seems appropriate to support men in their transition to fatherhood.
Perceived Benefits of Childbirth Education on Future Health-Care Decision Making
Authors: Leach Jane , Bowles Betty , Jansen Lauren , Gibson Martha 
Published: March 2017

ABSTRACTThe aim of this qualitative study was to explore the perception of women regarding long-term effects of childbirth education on future health-care decision making. This qualitative study used a purposive sample of 10 women who participated in facilitated focus groups. Analysis of focus group narratives provided themes in order of prevalence: (a) self-advocacy, (b) new skills, (c) anticipatory guidance, (d) control, (e) informed consent, and (f) trust. This small exploratory study does not answer the question of whether childbirth education influences future health-care decision making, but it demonstrates that the themes and issues from participants who delivered 15–30 years ago were comparable to current findings in the literature.
KHILAFAH ISLAMIYAH PERSPEKTIF AHMADIYAH (SEBUAH GERAKAN SPIRITUAL KEAGAMAAN)
Authors: Muhtador Moh 
Published: March 2017

Ahmadiyah adalah organisasi keagamaan yang didirikan di India oleh Mirza Ghulam Ahmad. Sebagai sebuah organisasi, Ahmadiyah menjadi wadah dalam mepersatukan umat muslim, sehingga Ahmadiyah berkembang di beberapa negara besar di Eropa dan Asia, termasuk Indonesia. Meski sebagai golongan minoritas di Indonesai, tetapi perkembanganya di negara Eropa sangat pesat. Ajaran toleransi dan kedamaian yang diajarkan oleh khalifah menjadi inspirasi gerakan spritual bagi pengikut Ahmadiyah. Jemat Ahmadi meyakini bahwa, seorang khalifah adalah pembimbing keagamaan yang bersifat rohani dan syariat, oleh sebab itu, dalam memberikan ajaran seorang khalifah selalu menekankan pada aspek kedamaian dan toleransi, seperti jargon “<em>love for all hatred for none”.</em> Pada wilayah tersebut Ahmadi lebih mengartikan khilafah yang bersifat spritual keagamaan dibanding politik kenegaraan. Hal ini yang membedakan antara Ahmdiyah dengan kelompok Islam lainnya, seperti ISIS, Al-Qaeda dan HTI. Ahmadiyah menekankan konsep khilafahnya pada wilayah spritualitas tanpa dibatasi dengan territorial, kesatuan jiwa dan rasa tidak dapat memisahkan jemaat Ahmadi dengan khalifahnya. Meskipun jemaat Ahmadi berada diberbagai negara, namun kesetiannya terhadap khalifah didasari dengan rasa cinta.
Interactional organization and pedagogic aims of reading aloud practices in L1 education
Authors: Tainio Liisa , Slotte Anna 
Published: March 2017

The aim of this article is to examine the activity of reading aloud is as it occurs in and through interaction in L1-classrooms. Our data consist of video-recorded classroom interaction in Finnish comprehensive schools (grade 6 with 12-year-old students). The method adopted is conversation analysis. This analysis encompasses reading aloud exercises with reference to genre, source of the text and recipients’ visual access or non-access to the text. According to our analysis, the oral reading of a text is used to create a shared reference point in classrooms in terms of allocating turns, emphasizing the importance of the content or ideology of the text, deepening the knowledge and motivation for learning, fostering writing skills, or merely to enjoy the text or to fill up lesson time. Our main objective is to offer new knowledge of oral reading as an interactional phenomenon and a pedagogic tool for developing literacy skills in a classroom setting.
O Programa Institucional de Bolsas de Iniciação Científica para o Ensino Médio (PIBIC-EM): a política pública, a ciência e a cidadania
Authors: Silva Larissa Reducino , Assis Ana Elisa Spaolonzi Queiroz 
Published: March 2017

Por meio do presente artigo, socializamos resultado de pesquisa cujo objetivo foi o de analisar a organização do Programa Institucional de Bolsas de Iniciação Científica para o Ensino Médio (PIBIC-EM) na Universidade Estadual de Campinas (UNICAMP) e a sua contribuição para a formação crítica dos estudantes do nível médio das escolas públicas no que diz respeito à ciência e a cidadania. A pesquisa, de caráter exploratório, foi realizada por meio de análise bibliográfica e documental – valendo-se dos materiais produzidos nos projetos desenvolvidos no Laboratório de Políticas Públicas e Planejamento Educacional (LaPPlanE) – discutindo o programa e a sua contribuição para a efetivação de um diálogo entre a Educação Básica e o Ensino Superior. O texto introduz o contexto nacional e local do Programa, para então apresentar os conceitos de ciência e de cidadania assumidos na pesquisa, bem como as atividades desenvolvidas nos projetos, e a partir daí estabelece uma relação dialógica entre essas atividades e a abordagem teórica, finalizando com algumas considerações vinculadas aos resultados da pesquisa, dos quais podemos destacar mudança significativa na forma como os alunos bolsistas entendem a ciência e se reconhecem como sujeitos de direito. Palavras-chave: Iniciação Científica. Ensino Médio. Cidadania.
Planos Municipais de Educação - perfil dos Municípios que não possuíam Plano Municipal de Educação no segundo ano de vigência da Lei N. 13.005/14
Authors: Nascimento Gilvânia Da Conceição , Grossi Junior Geraldo , Pereira Jhonata Moreira 
Published: March 2017

Em 2009 a elaboração do PNE passou a ser uma exigência constitucional. Com as deliberações da Conferência Nacional de Educação/2010, o Governo apresentou o PL 8025/2010. Depois de tramitar por aproximadamente quatro anos no Congresso Nacional foi sanciona a Lei N. 13.005/2014. Em seu artigo oitavo determina que todos os entes federativos deveriam instituir seus planos de educação no prazo de um ano após a publicação do PNE. Houve um esforço do Ministério da Educação juntamente com a Undime e o Consed, criando a Rede de Assistência Técnica para Elaboração ou Adequação dos Planos de Educação, visando assessorar os estados, o Distrito Federal e os municípios para cumprirem esta determinação legal. A fim de prestar o melhor suporte aos entes federativos, três meios de orientação foram constituídos: organização em rede, documentos orientadores e portal eletrônico de acesso à informação. Esta pesquisa, teve como recorte somente os 49 municípios que não cumpriram a determinação legal e buscou estabelecer um perfil destes, a partir de características comuns, visando identificar os motivos que levaram ao descumprimento do preceito legal. Para esta análise, foram estabelecidas as seguintes variáveis: população; IDHM; partido político da administração municipal; e, visão dos coordenadores estaduais da rede de Assistência Técnica da SASE/MEC. Os dados analisados nos permitiram identificar que embora não exista um perfil comum para estes municípios, existem pontos de convergência que ajudam a compreender as dificuldades dos municípios para o planejamento municipal de longo prazo. Palavras-chave: Planos de Educação. Regime de Colaboração. Perfil de Municípios.
O currículo e o estágio supervisionado na formação do professor de educação física na Amazônia
Authors: Carvalho Filho Josué José de , Brasileiro Tânia Suely Azevedo 
Published: March 2017

Este artigo e parte de uma dissertação de mestrado e traz reflexões sobre o Estágio Curricular Supervisionado na Amazônia. Com isso, o objetivo consistiu em analisar o estágio curricular supervisionado na formação do professor de Educação Física em uma IFES da região norte, levando em consideração seu currículo. A pesquisa foi descritiva/qualitativa, a partir de um estudo de caso no curso de Educação Física da UNIR. O marco teórico adotado dialogou com autores como: Bianchi, Alvarenga e Bianchi (2009), Contreras (2012), D’Avila (2013), Dourado (2015), Libâneo (2013), Pimenta (2012a, 2012b), Pimenta e Lima (2011) e Veiga (2010, 2004), entre outros que discutem a temática abordada. Os participantes e instrumentos do estudo foram dois docentes, um deles foi coordenador de curso e o outro o supervisor de estagio, e quatorze discentes, sendo aplicação de entrevista aos primeiros e questionário semiestruturado com os segundos. O tratamento e discussão das informações coletadas se deram à luz da análise de conteúdos de Bardin (2009). Os resultados revelaram que o estágio na formação do professor de Educação Física contribui para a mobilização de saberes e implica na decisão em “ser ou não ser” um professor. Trata-se, portanto, de uma proposta de estágio realimentada pelos sujeitos que vivem a teoria e a prática a partir do currículo vivido, pela profissão exercida e pelo compromisso com o futuro campo de trabalho. Palavras-chave: Estágio Curricular Supervisionado. Educação Física na Amazônia. Currículo.
EVALUASI STRATEGI BERSAING SMA KRISTEN 1 SALATIGA
Authors: Tehupeiory Eclesia , Sulasmono Bambang Suteng 
Published: March 2017

<p>This study aims to evaluate the competitive strategies of SMA Kristen 1 Salatiga. The type of this study was a qualitative evaluation, through data collection by means of interviews, questionnaires, observation and documentation study. Data obtained and analyzed by an evaluation component based on Rumelt (2000) were consistency, consonance, advantage and feasibility. The results showed that: (1) Consistency evaluation of competitive strategy applied by SMA Kristen 1 Salatiga has shown consistency with the goals, values and policies of the school. (2) Consonance evaluation of competitive strategy has demonstrated suitability with the needs of society, while for competition with other schools, the school programs such as Peduli Kasih program, Sekolah Lima Hari, moving class, SMUQI Radio and multimedia extracurricular namely cinematography and photography are not appropriate. (3) Advantage evaluation of competitive strategy in the school programs such as Peduli Kasih, moving class, and Sekolah Lima Hari do not excel the resources, skills and superior positions. Other programs such as multimedia Extracurricular namely photography and cinematography is not superior to the superior position. Meanwhile, special programs such as the education expo, parenting day, career day and the Field Trip program through Live In and outdoor study do not excel in superior skills. (4) Feasibility evaluation shows that multimedia extracurricular programs have not showed the feasibility of the physical resources which involves computer supporting facilities and Wi-Fi. Suggestion to school in order to maintain the consistency that was owned, suitability to the needs of society as well as pay attention to competition with other schools also enhance the achievement of advantage and checking of IT facilities.</p>
PENERAPAN SUPERVISI KUNJUNGAN KELAS UNTUK MENINGKATKAN KINERJA GURU SEKOLAH DASAR NEGERI
Authors: Danurwati Suprih , Slameto Slameto 
Published: March 2017

<p>This study aimed to know that the implementation of classroom visit supervision can improve the performance of teachers SD Negeri 2 Kalimanggis in learning management. Subjects in this study were teachers at the SD Negeri 2 Kalimanggis, Kaloran District, Temanggung. The procedure used in this study consisted of three series of activities that will be carried in repeating cycles, include (a) planning, (b) the action by observation, and (c) reflection. The research approach used action research methods, while the data collection used study of documentation, observation, questionnaires and interviews. The results showed an increased ability of teachers to prepare lesson plans and manage the learning of the first, second, to the third action. The conclusion was the classroom visit supervision can improve the performance of teachers at SDN 2 Kalimanggis in learning management. Suggestions given to teacher was need to utilize the supervision activities as a source of information to improve teachers competence and performance. For the school principle need to utilize the result of this study as a reference in conducting research, while for school supervisor also need to utilize the results of this study as one of the references in the activities guidance towards principal and teachers in improving their performance.</p>
PENERAPAN SUPERVISI KUNJUNGAN KELAS UNTUK MENINGKATKAN KINERJA GURU SD NEGERI 2 KALIMANGGIS KECAMATAN KALORAN, TEMANGGUNG
Authors: Danurwati Suprih , Slameto Slameto 
Published: March 2017

<p>Suprih Danurwati, 942013161. Implementation of supervision class visiting to increase teacher’s performance of SD Negeri 2 Kalimanggis District of Kaloran. Thesis. The graduatiton Program Master of Management Education Satya Wacana Christian University Salatiga. Supervisor Prof. Dr. Slameto, M.Pd. This study is to determine that through the implementation of supervision class visiting can improve the performance of teachers in the learning management. The subjects of this study are teachers in SD Negeri 2 Kalimanggis, Kaloran, Temanggung. The procedure used in this study consists of a series of three main activities undertaken in a repeating cycle, including (a) plan, (b) action by observation, and (c) reflection. research approach using action research methods, while the method of data collection using the study documentation, observations, questionnaires, and interviews. The results showed an increasing in the ability of teachers to prepare lesson plans and manage the learning of the first act, second, until the third act. The inference that supervision class visiting that can improve the performance of teachers in the learning management. Suggestions given to teachers, is taking advantage of supervision activities as a source of information to improve the competence and performance, for principals use the results of this study as a reference in conducting research, while for school superintendent will use the results of this study as one of the references in activity guidance to the heads of schools and teachers to improve their performance.</p>
PENGUASAAN KOMPETENSI PEDAGOGIK GURU TERSUPERVISI KLINIS DAN GURU TANPA SUPERVISI DI DUA SMA SWASTA DI KOTA AMBON
Authors: Kaipatty Leinora Juliana , Loekmono Lobby , Slameto Slameto 
Published: March 2017

<p>This study is an experimental research with using pretest and posttest control group design. The aimed of the study were: 1). To know the differences significant of teacher’s mastery of pedagogical competences between teachers clinical supervised in SMA Kristen YPKPM Ammbon and non-supervised teachers in SMA Kartika XIII-I Ambon, 2). To determine how the the clinical supervision influenced the teachers’ mastery of pedagogical competences. The data was collected by using observation toward teaching profile competence from Wasserman and Egert. Data analyzed using t test comparative and linear regression analysis. The result of the study was the coefficient t test was 4,184 with significant 0,001 &lt; 0,05. It proved that there was a difference between supervision and non-supervision teachers significantly. The clinical supervision has influence about 41,9% on teachers pedagogical competences.</p>
EFEKTIFITAS PENERAPAN PROJECT BASED LEARNING BERBANTUAN WEB 2.0 TOOLS DAN DEMING CYCLE PADA MATAKULIAH PEMECAHAN MASALAH MATEMATIKA
Authors: Yemima Nohel 
Published: March 2017

<p>This is a Quasi Experimental research which aimed to know the effectiveness of implementing Project Based Learning (PBL) with assistance of Web 2.0 tools and Deming Cycle towards the learning achievement in Mathematics Problem Soving Course of undergraduate students in Primary School Teacher Education Program in Satya Wacana Christian Univerisity (PGSD, UKSW). This research included 52 students which were devided into two classes consist of 26 students. In the experimental group, the treatment were given by implementing a PBL with Web 2.0 tools and Deming Cycle whereas in control group, PBL was implemented but without the use of Web 2.0 tools and Deming Cycle. The T-Test anylisis showed that the experimental group had the significant increasing of learning achievement compare to the control group. As the result, in the third term of 2013/2014 accademic year, it is effective to improve students learning achievement in Mathematics Problem Solving Course by implementing PBL with the assistance of Web 2.0 tools and Deming Cylce.</p>
ANTUSIASME GURU DALAM PROGRAM PENGEMBANGAN KOMPETENSI PEDAGOGIK DAN DETERMINANNYA *)
Authors: Samuel Donald 
Published: March 2017

<p>This study aimed to describe the enthusiasm of the teachers at SMPN 2 Gedangsari, Gunung kidul in the program of Education and Training (Dik-lat) for pedagogic competence development, organized by the Education Foundation of Astra-Michael D. Ruslim (which is running a program of Corporate Social Responsibility in the field of education in the middleschool. In addition, this study also aimed to find the determinant factor for the enthusiasm of the teachers. This research applied mixed method. The results showed enthusiasm in participating in teacher training pedagogical competence development was quite high. In quantitative terms, the level of enthusiasm of teachers was worth on average 3.8 with H was rejected (teacher enthusiasm was high). In addition, there were several determinants affecting the enthusiasm of teachers, namely, the intensity of individual meetings (b value = 0.633), while the suitability of the teacher trainers approach did not affect the enthusiasm (b value = 0.364). Thus, the trainer advised to frequently meet with the teacher so that the enthusiasm of teachers increased, and dik-lat program targets could be achieved well. 0</p>