bluuebunny/crossref_metadata_2025_split huggingface dataset:
WDNfinder: A method for minimum driver node set detection and analysis in directed and weighted biological network
Authors: Chu Yanshuo , Wang Zhenxing , Wang Rongjie , Zhang Ningyi , Li Jie , Hu Yang , Teng Mingxiang , Wang Yadong 
Published: September 2017

Structural controllability is the generalization of traditional controllability for dynamical systems. During the last decade, interesting biological discoveries have been inferred by applied structural controllability analysis to biological networks. However, false positive/negative information (i.e. nodes and edges) widely exists in biological networks that documented in public data sources, which can hinder accurate analysis of structural controllability. In this study, we propose WDNfinder, a comprehensive analysis package that provides structural controllability with consideration of node connection strength in biological networks. When applied to the human cancer signaling network and p53-mediate DNA damage response network, WDNfinder shows high accuracy on essential nodes prediction in these networks. Compared to existing methods, WDNfinder can significantly narrow down the set of minimum driver node set (MDS) under the restriction of domain knowledge. When using p53-mediate DNA damage response network as illustration, we find more meaningful MDSs by WDNfinder. The source code is implemented in python and publicly available together with relevant data on GitHub: https://github.com/dustincys/WDNfinder .
Subterranean millipedes (Diplopoda) of the Iberian Peninsula
Authors: REBOLEIRA ANA SOFIA P.S. , ENGHOFF HENRIK 
Published: September 2017

We present a checklist of subterranean millipedes from the Iberian Peninsula. Among the 16 orders of millipedes present worldwide, nine are represented in the Iberian Peninsula, of which five have troglobiont species: Polyxenida, Glomerida, Polydesmida, Chordeumatida and Julida. Currently, 75 species of troglobiont millipedes are known from the Iberian Peninsula, although only 68 have been described so far. Most of this diversity occurs in Spain, while only seven species are known from Portugal, two endemic to Gibraltar, and three in the Balearic archipelago. We compiled all of the literature and added our own records of the troglobiont millipedes known in the Iberian Peninsula.
An fMRI study of the effects on normal language areas when acupuncturing the Tongli (HT5) and Xuanzhong (GB39) acupoints
Authors: Liu Shuyong , Li Min , Tang Weijun , Wang Guangbin , Lv Yinghui 
Published: September 2017

Objective Functional magnetic resonance imaging (fMRI) analysis of the effects of acupuncturing the Tongli (HT5) and Tongli (HT5)–Xuanzhong (GB39) acupoints on the normal language areas with a view to providing a theoretical basis for using acupuncture to treat patients with aphasia. Methods This study enrolled healthy volunteers. The following acupoints were stimulated: right Tongli (HT5), right Tongli (HT5)–Xuanzhong (GB39), right Tongli (HT5) sham acupuncture, left Tongli (HT5), and left Tongli (HT5)–Xuanzhong (GB39) acupoints. Acupuncture stimulation was delivered whilst fMRI scanning of the brain was undertaken. Results Ten healthy volunteers (five males) were included in this study (mean age 44.5 ± 2.5 years; range 40–55 years). Based on the statistical analyses, only acupuncturing the right Tongli (HT5) acupoint resulted in activation of multiple regions of the bilateral cerebral hemisphere that were closely related to the language regions. The right Tongli (HT5) stimulation had a laterality index of 0.0952; with the activated voxels on the left side language-related areas being greater than those on the right side. Conclusions Acupuncturing the right Tongli (HT5) acupoint results in activation of the bilateral language-related areas, so this acupoint might be useful for the acupuncture treatment of aphasia caused by cerebral infarction.
Expanding collaborative care: integrating the role of dietitians and nutrition interventions in services for people with mental illness
Authors: Teasdale Scott B , Latimer Geogina , Byron Annette , Schuldt Vanessa , Pizzinga Josephine , Plain Janice , Buttenshaw Kerryn , Forsyth Adrienne , Parker Elizabeth , Soh Nerissa 
Published: September 2017

Objective: This article aims to draw mental health clinicians’ attention to the connections between nutrition and mental health, and the roles that Accredited Practising Dietitians play in improving mental and physical health through dietary change. Methods: Selective narrative review. Results: Unhealthy dietary practices are common in high prevalence and severe mental illness. Epidemiological evidence demonstrates that nutrients and dietary patterns impact on mental health. In addition, poor physical health is well documented in people with mental illness and the greatest contributor to the mortality gap. Dietary intervention studies demonstrate improved mental and physical health outcomes. Accredited Practising Dietitians translate nutrition science into practical advice to improve the nutritional status of patients with mental illness, and prevent and manage comorbidities in a variety of care settings. Conclusions: Medical Nutrition Therapy offers opportunities to improve the physical and mental health of people living with mental illness.
Hope, recovery and symptoms: the importance of hope for people living with severe mental illness
Authors: Hayes Laura , Herrman Helen , Castle David , Harvey Carol 
Published: September 2017

Objectives: Hope is an important part of recovery from severe mental illness. Our aim was to assess hope and its correlation with symptoms in people living with severe mental illness. Methods: We used validated questionnaires to assess hope, social isolation, quality of life and symptoms among 60 people living with severe mental illness. Results: Hope scores were significantly lower than those reported for many community groups. There was a negative association between psychiatric symptoms and levels of hope. Conclusions: Some people living with enduring severe mental illness in the Australian community feel hopeless. Being hopeful and initiating recovery are evidently difficult when symptoms remain severe. Appropriate acknowledgement and support for patients and their families is required.
Mutuality and heart failure self-care in patients and their informal caregivers
Authors: Hooker Stephanie A , Schmiege Sarah J , Trivedi Ranak B , Amoyal Nicole R , Bekelman David B 
Published: September 2017

Background: Heart failure is a progressive condition characterized by frequent hospitalizations for exacerbated symptoms. Informal family caregivers may help patients improve self-care, which may in turn reduce hospitalizations. However, little is known about how mutuality, defined as the quality of the patient–caregiver relationship, and caregiver burden affect self-care. Objective: This study examines the associations among mutuality, patient self-care confidence (beliefs in abilities to engage in self-care behaviors) and maintenance (behaviors such as medication adherence, activity, and low salt intake), caregiver confidence in and maintenance of patient care, and caregiver perceived burden. Methods: This study used cross-sectional baseline data from a multi-site randomized clinical trial of a symptom and psychosocial care intervention. Patient–caregiver dyads ( N=99) completed self-report surveys of mutuality and self-care confidence and maintenance, and caregivers completed a measure of caregiver burden. Path analysis, with actor (effects within a person) partner (effects across the dyad) interdependence model paths and regression models were used to examine the associations among mutuality, caregiver burden, and self-care. Results: The majority of patients ( M age=66, 21% female) and caregivers ( M age=57, 81% female) were spouses (60%). The path model demonstrated significant actor effects; patients and caregivers with better mutuality were more confident in patient self-care ( p<.05). Partner effects were not significant. Regression models indicated that caregivers with greater mutuality reported less perceived burden ( p<.01). Conclusions: Mutuality in patient–caregiver dyads is associated with patient self-care and caregiver burden and may be an important intervention target to improve self-care and reduce hospitalizations.
(Dis)Ableing Notions of Authentic Leadership Through the Lens of Critical Disability Theory
Authors: Procknow Greg , Rocco Tonette S. , Munn Sunny L. 
Published: September 2017

The Problem Persons with disabilities (PWD) are regarded as “the Other” and are sequestered from “normative” society because of their “Otherness.” “Othering” results in discrimination and the systemic preclusion of PWD. Ableism is the belief that being without a disability, impairment, or chronic illness is the norm. The notion that people without disabilities are the norm and are inherently superior is accepted without critique by those that advocate for authentic leadership. This privileges ableism and furthers the “Othering” of PWD within a leadership style intended to promote self-awareness, beliefs and ethics, and interpersonal relationships. The Solution The disabled experience and differently abled voice must be restored through relationally “being” with others and authentic dialogue. What is needed is a shift from the deficit model of authentic leadership to a social paradigm of authentic leadership, welcoming of bodily and psychic difference. This will better enable both leaders and employees to craft an authentic profile in the workplace. The Stakeholders Leaders and those who seek to become leaders following an authentic leadership approach can benefit from a better understanding of how their ingrained belief systems impact those that they lead who are both “able-bodied” and “disabled.” Human resource development (HRD) practitioners and leadership development practitioners can use this information to deconstruct and reconstruct leadership development opportunities to be inclusive as an authentic leader.
An Examination of Sociocultural Factors Associated With Mammography Screening Among Latina Immigrants
Authors: Luque John S. , Tarasenko Yelena N. , Bryant Debbie Chatman , Davila Caroline , Soulen Grace 
Published: September 2017

Introduction: The study hypothesized that sociocultural factors would be associated with breast cancer screening within the past 2 years among Latina immigrant women. Method: This study employed a survey design and included 82 Latina immigrant female participants 40 to 64 years of age for the analysis. Two multivariable binary logistic regression models were estimated, one for the sociocultural deterrents and the other for the symptomatic deterrents from the Cultural Cancer Screening Scale. Results: The results indicated two constructs of the Cultural Cancer Screening Scale, sociocultural deterrents (odds ratio = 2.00; 95% confidence interval = 1.04-3.86) and symptomatic deterrents (odds ratio = 1.65; 95% confidence interval = 1.08-2.54), were associated with screening in the past 2 years, when adjusting for sociodemographic and health-related characteristics. Conclusion: These findings provide evidence for the importance of sociocultural factors in Latina immigrant women’s timely mammography screening.
A telehealth intervention to promote healthy lifestyles after stroke: The Stroke Coach protocol
Authors: Sakakibara Brodie M , Lear Scott A , Barr Susan I , Benavente Oscar , Goldsmith Charlie H , Silverberg Noah D , Yao Jennifer , Eng Janice J 
Published: September 2017

Rationale Recurrent stroke is prevalent and associated with high mortality rates, disability, and social and economic costs. Adequate management of risk factors may reduce recurrent stroke; however, many stroke survivors have poor control of risk factors. We have developed a theoretically sound and evidence-based lifestyle modification program called the Stroke Coach, a telephone-based self-management program to improve control of risk factors. Hypothesis Individuals who participate in Stroke Coach will achieve more lifestyle improvements than individuals in an attention controlled Memory Training Program. Design In this single blind randomized controlled trial, 126 community-living stroke survivors will be randomized to Stroke Coach or the attention control group. Participants randomized to the six-month Stroke Coach will receive seven telephone lifestyle coaching sessions, self-management education and practice, and a self-monitoring kit, comprised of a health report card, with blood pressure and activity monitors. Study Outcomes The primary outcome will be measured using the Health Promoting Lifestyle Profile II. Secondary outcomes include behavioral and physiological risk factors, quality of life, cognitive status, health and social service use. Measurements will be taken at baseline, immediately after the intervention and six-month post-intervention. Summary The results of this trial will add to our understanding of the use of self-management to improve control of risk factors, and may facilitate the development of a larger trial evaluating the effect of Stroke Coach on endpoints such as recurrent stroke or cardiac events as the primary outcome.
Optical improvements in the diagnosis of bladder cancer: implications for clinical practice
Authors: Schubert Tina , Rausch Steffen , Fahmy Omar , Gakis Georgios , Stenzl Arnulf 
Published: September 2017

Background For over 100 years white-light cystoscopy has remained the gold-standard technique for the detection of bladder cancer (BCa). Some limitations in the detection of flat lesions (CIS), the differentiation between inflammation and malignancy, the inaccurate determination of the tumor margin status as well as the tumor depth, have led to a variety of technological improvements. The aim of this review is to evaluate the impact of these improvements in the diagnosis of BCa and their effectiveness in clinical practice. Methods A systematic literature search was conducted according to the PRISMA statement to identify studies reporting on imaging modalities in the diagnosis of NMIBC between 2000 and 2017. A two-stage selection process was utilized to determine eligible studies. A total of 74 studies were considered for final analysis. Results Optical imaging technologies have emerged as an adjunct to white-light cystoscopy and can be classified according to their scope as macroscopic, microscopic and molecular. Macroscopic techniques including photodynamic diagnosis (PDD), narrow-band imaging (NBI) and the Storz Professional Image Enhancement System (IMAGE1 S, formerly known as SPIES) are similar to white-light cystoscopy, but are superior in the detection of bladder tumors by means of contrast enhancement. Especially the detection rate of very mute lesions in the bladder mucosa (CIS) could be significantly increased by the use of these methods. Microscopic imaging techniques like confocal laser endomicroscopy and optical coherence tomography permit a real-time high-resolution assessment of the bladder mucosa at a cellular and sub-cellular level with spatial resolutions similar to histology, enabling the surgeon to perform an ‘optical biopsy’. Molecular techniques are based on the combination of optical imaging technologies with fluorescence labeling of cancer-specific molecular agents like antibodies. This labeling is intended to favor an optical distinction between benign and malignant tissue. Conclusions Optical improvements of the standard white-light cystoscopy have proven their benefit in the detection of BCa and have found their way into clinical practice. Especially the combination of macroscopic and microscopic techniques may improve diagnostic accuracy. Nevertheless, HAL-PDD guided cystoscopy is the only approach approved for routine use in the diagnosis of BCa by most urological associations in the EU and USA to date.
Functional and quality of life outcomes after partial glossectomy: A multi-institutional longitudinal study of the head and neck research network
Authors: Dzioba Agnieszka , Aalto Daniel , Papadopoulos-Nydam Georgina , Seikaly Hadi , Rieger Jana , Wolfaardt Johan , Osswald Martin , Harris Jeffrey R. , O'Connell Daniel A. , Lazarus Cathy , Urken Mark , Likhterov Ilya , Chai Raymond L. , Rauscher Erika , Buchbinder Daniel , Okay Devin , Happonen Risto-Pekka , Kinnunen Ilpo , Irjala Heikki , Soukka Tero , Laine Juhani ,   Head and Neck Research Network
Published: September 2017

Background While aggressive treatment for oral cancer may optimize survival, decrements in speech and swallowing function and quality of life often result. This exploratory study investigated how patients recover their communicative function, swallowing ability, and quality of life after primary surgery [with or without adjuvant (chemo)radiation therapy] for tongue cancer over the course of the first year post-operation. Methods Patients treated for oral cancer at three institutions (University of Alberta Hospital, Mount Sinai Beth Israel Medical Center, and Turku University Hospital) were administered patient-reported outcomes assessing speech [Speech Handicap Index (SHI)], swallowing [(M.D. Anderson Dysphagia Inventory (MDADI)] and quality of life [European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Head and Neck Module (EORTC-H&N35)]. Outcome measures were completed pre-operatively and at 1-, 6-, and 12-months post-operatively. Results One hundred and seventeen patients undergoing partial glossectomy with reconstruction participated in this study. Results indicated no significant differences in swallowing function (MDADI and EORTC-H&N35 subscales) between baseline and 6 months post-surgery and no significant differences in speech function (SHI subscales) between baseline and 1 year post-surgery. Most quality of life domains (EORTC-H&N35 subscales) returned to baseline levels by 1 year post-operation, while difficulties with dry mouth and sticky saliva persisted. A clear time trend of adjuvant (chemo)radiation therapy negatively affecting dry mouth scores over time was identified in this study, while negative independent effects of chemoradiation on MDADI swallowing, and EORTC-H&N35 swallowing, eating, and opening mouth subscales were found. Conclusions Assessment time influenced patient-reported speech, swallowing, and quality of life outcomes, while treatment (by time) effects were found for only swallowing and quality of life outcomes. Results of the present study will help guide clinical care and will be useful for patient counseling on expected short and long-term functional and quality of life outcomes of surgical and adjuvant treatment for oral cavity cancer.
A prospective analysis of risk factors for pediatric burn mortality at a tertiary burn center in North India
Authors: Dhopte Amol , Bamal Rahul , Tiwari Vinay Kumar 
Published: September 2017

Abstract

Background
None of the available mortality predicting models in pediatric burns precisely predicts outcomes in every population. Mortality rates as well as their risk factors vary with regions and among different centers within the regions. The aim of this study was to identify socio-demographic and clinical risk factors for mortality in pediatric burns in an effort to decrease the mortality in these patients.

Methods
A prospective analytical study was conducted in patients up to the age of 18 years admitted for burn injuries in a tertiary care burn center in India from January to December 2014. Clinical and demographic data was collected through questionnaire-interview and patient follow-up during their stay in the hospital. Univariate and multivariate firth logistic regression was used to identify various risk factors for mortality in pediatric burns.

Results
A total of 475 patients were admitted during the study period. Overall mortality was 31.3% (n = 149) in this study. Mean age of the patients who died was 8.68 years. Of the 149 deaths, 74 were males and 75 were females (male to female ratio = 0.98). Mean total body surface area (TBSA) involved of the patients who expired was 62%. Inhalational injury was seen in 15.5% (n = 74) of pediatric burn admissions. Mortality was significantly higher (74.3%) in patients with inhalation injury. Mortality was highest in patients with isolates of Acinetobacter + Klebsiella (58.3%), followed by Pseudomonas + Klebsiella (53.3%), Acinetobacter (31.5%), and Pseudomonas (26.3%) (p &lt; 0.0005). Factors found to be significant on univariate firth analysis were older age, female gender, suicidal burns, higher TBSA, presence of inhalation injury, increased depth of burn, and positive microbial cultures. On multivariate analysis, higher TBSA was identified as an independent risk factor for mortality. The adjusted odds ratios for TBSA involvement was 21.706 (25.1-50%), 136.195 (50.1-75%), and 1019.436 (75.1-100%), respectively.

Conclusion
TBSA is the most important factor predicting mortality in pediatric burns. The higher the TBSA, the higher is the risk of mortality. Other significant risk factors for mortality are female gender, deeper burns, positive wound cultures, and inhalation injury. Risk of mortality was significantly lower in children who belonged to urban areas, nuclear family, who sustained burn injury in the last quarter of the year, and who stayed in the hospital for longer period.
Approach to interpret images produced by new generations of multidetector CT scanners in post-operative spine
Authors: Zeitoun Rania , Hussein Manar 
Published: September 2017

Objective:
To reach a practical approach to interpret MDCT findings in post-operative spine cases and to change the false belief of CT failure in the setting of instruments secondary to related artefacts.

Methods:
We performed observational retrospective analysis of premier, early and late MDCT scans in 68 post-operative spine patients, with emphasis on instruments related complications and osseous fusion status. We used a grading system for assessment of osseous fusion in 35 patients and we further analysed the findings in failure of fusion, grade (D).

Results:
We observed a variety of instruments related complications (mostly screws medially penetrating the pedicle) and osseous fusion status in late scans. We graded 11 interbody and 14 posterolateral levels as osseous fusion failure, showing additional instruments related complications, end plates erosive changes, adjacent segments spondylosis and malalignment.

Conclusion:
Modern MDCT scanners provide high quality images and are strongly recommended in assessment of the instruments and status of osseous fusion. In post-operative imaging of the spine, it is essential to be aware for what you are looking for, in relevance to the date of surgery.

Advances in knowledge:
Modern MDCT scanners allow assessment of instruments position and integrity and osseous fusion status in post-operative spine. We propose a helpful algorithm to simplify interpreting post-operative spine imaging.