bluuebunny/crossref_metadata_2025_split huggingface dataset:
Amyloid PET detects the deposition of brain Aβ earlier than CSF fluid biomarkers
Authors: Lowe Val J. , Mester Carly T. , Lundt Emily S. , Lee Jeyeon , Ghatamaneni Sujala , Algeciras‐Schimnich Alicia , Campbell Michelle R. , Graff‐Radford Jonathan , Nguyen Aivi , Min Hoon‐Ki , Senjem Matthew L. , Machulda Mary M. , Schwarz Christopher G. , Dickson Dennis W. , Murray Melissa E. , Kandimalla Karunya K. , Kantarci Kejal , Boeve Bradley , Vemuri Prashanthi , Jones David T. , Knopman David , Jack Clifford R. , Petersen Ronald C. , Mielke Michelle M. 
Published: October 2024

AbstractINTRODUCTIONUnderstanding the relationship between amyloid beta (Aβ) positron emission tomography (PET) and Aβ cerebrospinal fluid (CSF) biomarkers will define their potential utility in Aβ treatment. Few population‐based or neuropathologic comparisons have been reported.METHODSParticipants 50+ years with Aβ PET and Aβ CSF biomarkers (phosphorylated tau [p‐tau]181/Aβ42, n = 505, and Aβ42/40, n = 54) were included from the Mayo Clinic Study on Aging. From these participants, an autopsy subgroup was identified (n = 47). The relationships of Aβ PET and Aβ CSF biomarkers were assessed cross‐sectionally in all participants and longitudinally in autopsy data.RESULTSCross‐sectionally, more participants were Aβ PET+ versus Aβ CSF− than Aβ PET− versus Aβ CSF+ with an incremental effect when using Aβ PET regions selected for early Aβ deposition. The sensitivity for the first detection of Thal phase ≥ 1 in longitudinal data was higher for Aβ PET (89%) than p‐tau181/Aβ42 (64%).DISCUSSIONAβ PET can detect earlier cortical Aβ deposition than Aβ CSF biomarkers. Aβ PET+ versus Aβ CSF− findings are several‐fold greater using regional Aβ PET analyses and in peri‐threshold‐standardized uptake value ratio participants.Highlights
Amyloid beta (Aβ) positron emission tomography (PET) has greater sensitivity for Aβ deposition than Aβ cerebrospinal fluid (CSF) in early Aβ development.
A population‐based sample of participants (n = 505) with PET and CSF tests was used.
Cortical regions showing early Aβ on Aβ PET were also used in these analyses.
Neuropathology was used to validate detection of Aβ by Aβ PET and Aβ CSF biomarkers.
Nitrogen‐Oxidized Tröger's Base Macrocyclic Arenes: Unprecedented Enantioselective Recognition in Water
Authors: Liang Xiaotong , Zhao Ting , Shen Yanling , Fang Lizhi , Chen Long , Zhou Dayang , Wu Wanhua , Yang Cheng 
Published: October 2024

AbstractAchieving high enantioselectivity with synthetic receptors, particularly in water, remains a significant challenge despite the success seen in natural biological systems. In this study, we introduce a facile synthesis of Tröger's base (TB)‐containing macrocyclic arenes (TBn), where TB units are linked via methylene bridges, providing the macrocycles with a rigid framework. Oxidation of enantiopure TBn yields corresponding chiral nitrogen oxides (TBnNO) with excellent water solubility, attributed to the high polarity of the N−O bond, surpassing the pH limitations of traditional ion‐functionalized approaches. Remarkably, TBnNO exhibits exceptional enantioselective recognition toward a wide range of chiral guests in aqueous solution, achieving enantioselectivities as high as 41.0. The underlying mechanism involves a combination of hydrophobic interactions and steric effects caused by rigid chiral cavities. These findings highlight the potential of nitrogen‐oxidized macrocycles as a transformative tool for supramolecular application in water.
Removal and mechanism investigation of polycyclic aromatic hydrocarbons in coconut oils by ionic liquids
Authors: Zhao Gege , Xu Haoyu , Zhang Hai , Zhang Hong , Bi Yanlan , Xu Xuebing 
Published: October 2024

AbstractCrude coconut oil often contains high levels of polycyclic aromatic hydrocarbons (PAHs), which are commonly carcinogenic. The present work demonstrated that PAHs in coconut oil were significantly removed by ionic liquids (ILs). The relationship between the removal efficiency and the structures of ILs was investigated, using 12 different types ILs. Among these, 1‐butyl‐3‐methylimidazolium tosylate ([Bmim][TOS]) showed the highest efficiency in removing benzo(a)pyrene (BaP). The optimal process conditions for the removal of PAHs using [Bmim][TOS] were explored, and the removal efficiency for benzo(a)anthracene (BaA), chrysene (CHR), benzo(b)fluoranthene (BbF), and BaP under the optimal conditions were 42.7 ± 1.0, 33.3 ± 1.4, 88.8 ± 0.9, and 73.8 ± 1.0%, respectively. Importantly, [Bmim][TOS] could be recycled up to five times without a significant decrease in PAHs removal. The quantum chemistry calculations and spectrum analyses were conducted to study the interactions between ILs and PAHs, using BaP as a model compound. The ability of [Bmim][TOS] to remove PAHs originate its high hydrogen bond accepting ability and the collaborative hydrogen bond interactions between the PAHs and ILs.
Synthesis of perylene‐PEO hyperdispersants for aqueous graphene dispersion
Authors: Yong Yuxuan , Kang Yafang , Zhu Aiping 
Published: October 2024

AbstractGraphene, with excellent thermal conductivity, electrical and corrosion shielding performance has great application potential in the fields of heat dissipation coating, conductive agent and anticorrosion composite coatings. However, due to its large specific surface area, resulting strong aggregation behavior limits its application. Herein, the hyperdispersants with perylene anchoring groups are synthesized through the amidation coupling reaction between diacid anhydride and polyetheramine. The branching degree and length of hydrophilic chains on hyperdispersant are revealed to be the very important factors to affect the dispersion stability of aqueous graphene dispersion. The hyperdispersant with a single hydrophilic chain and the molecular weight 2000 of polyetheramine has the excellent dispersal activity discovered by Rheology, particle size distribution and Raman measurements. The possible mechanism is the strongest anchoring effect of perylene on graphene surface and thus achieving in best effective spatial exclusion stabilization effect of hydrophilic chains.
When data sharing is an answer and when (often) it is not: Acknowledging data‐driven, non‐data, and data‐decentered cultures
Authors: Huvila Isto , Sinnamon Luanne S. 
Published: October 2024

AbstractContemporary research and innovation policies and advocates of data‐intensive research paradigms continue to urge increased sharing of research data. Such paradigms are underpinned by a pro‐data, normative data culture that has become dominant in the contemporary discourse. Earlier research on research data sharing has directed little attention to its alternatives as more than a deficit. The present study aims to provide insights into researchers' perspectives, rationales and practices of (non‐)sharing of research data in relation to their research practices. We address two research questions, (RQ1) what underpinning patterns can be identified in researchers' (non‐)sharing of research data, and (RQ2) how are attitudes and data‐sharing linked to researchers' general practices of conducting their research. We identify and describe data‐decentered culture and non‐data culture as alternatives and parallels to the data‐driven culture, and describe researchers de‐inscriptions of how they resist and appropriate predominant notions of data in their data practices by problematizing the notion of data, asserting exceptions to the general case of data sharing, and resisting or opting out from data sharing.
Nonlinear control of a planar vertical take‐off and landing with a slung load
Authors: Lozano Rogelio , Gonzalez‐Hernandez Ivan , Salazar Sergio , Calderon Samantha 
Published: October 2024

AbstractThis paper presents the development of the dynamical model of a planar vertical take‐off and landing (PVTOL) carrying a suspended load. The complete model is obtained using the Euler–Lagrange approach. Furthermore, the synthesis of a nonlinear control is presented that stabilizes the vehicle to a desired position, and the load is stabilized as well. The stability is obtained using LaSalle invariance theorem. The performance of the obtained controller is shown in numerical simulations.
Wärmedämmverbundsysteme mit Holzfaserdämmplatten
Authors: Rüther Norbert , Li Xinyi , Sieder Mike 
Published: October 2024

AbstractWärmedämmverbundsysteme werden in Systemprüfungen hinsichtlich ihrer Gebrauchstauglichkeit und Standsicherheit untersucht. Die Prüfungen sind über Jahrzehnte entstanden und bergen einzelne Schwachstellen. Die Prognose des Trag‐ und Verformungsverhaltens mittels rechnerischer Methoden ist bisher in der Praxis unüblich, würde jedoch große Zeit‐ und Kostenersparnisse ermöglichen können. Insgesamt hat sich über die Jahrzehnte eine unbefriedigende Situation eingestellt. Im Rahmen mehrerer Vorhaben wurden umfangreiche experimentelle und rechnerische Untersuchungen an Materialien, Materialkombinationen und Bauteilen durchgeführt, die insgesamt zu einem größeren Verständnis bauphysikalischer und mechanischer Eigenschaften führen sollen. Die Erkenntnisse können dazu beitragen, das Trag‐ und Verformungsverhalten von WDVS mit Holzfaserdämmplatten mittels rechnerischer Verfahren prognostizieren zu können. In diesem Beitrag wird die Vorgehensweise innerhalb eines Forschungsvorhabens beschrieben. Die Ergebnisse der Arbeiten zeigen die Möglichkeiten der Simulation auf.
TRIP13: A promising cancer immunotherapy target
Authors: Jing Shengnan , Zhao Liya , Zhao Liwen , Gao Yong‐Jing , He Tianzhen 
Published: October 2024

AbstractThe tumor microenvironment (TME) facilitates tumor development through intricate intercellular signaling, thereby supporting tumor growth and suppressing the immune response. Thyroid hormone receptor interactor 13 (TRIP13), an AAA+ ATPase, modulates the conformation of client macromolecules, consequently influencing cellular signaling pathways. TRIP13 has been implicated in processes such as proliferation, invasion, migration, and metastasis during tumor progression. Recent studies have revealed that TRIP13 also plays a role in immune response suppression within the TME. Thus, inhibiting these functions of TRIP13 could potentially enhance immune responses and improve the efficacy of immune checkpoint inhibition. This review summarizes the recent research progress of TRIP13 and discusses the potential of targeting TRIP13 to improve immune‐based therapies for patients with cancer.
Steering Photoinduced Electron Transfer in Intramolecular Photocatalysts by Peripheral Ligand Control
Authors: Bagemihl Benedikt , Müller Carolin , Shillito Georgina E. , Hartkorn Marco , Mengele Alexander K. , Kupfer Stephan , Dietzek‐Ivanšić Benjamin , Rau Sven 
Published: October 2024

AbstractBridged photosensitizer‐catalyst systems are promising models to study photocatalytic hydrogen evolution. However, the systems in the literature structurally diverse and therefore hard to compare. Many systems show highly complex photophysics including several accepting orbitals for the excited state, as a result catalytic activity is hard to predict. Here we present a bimetallic Ru−Pt photocatalyst bearing peripheral spectator ligands at the ruthenium(II) photocenter as a member of the Ru‐tpphz‐Pt family. Consequently, it features a single acceptor tpphz ligand and so‐called unidirectional electron transfer, i. e., electron transfer without co‐occurring transfer to peripheral ligands, from the excited state. Thus – and in contrast to recently used peripheral ligands – the new spectator ligands do not disrupt electron transfer towards the catalytic center. By comparison to known systems, this facilitates unprecedented insight into the importance of electron transfer from the bridge to the catalytic center moving towards more rational design of oligonuclear photocatalysts.
In‐Situ Polymerized Solid/Quasi‐Solid Polymer Electrolyte for Lithium‐Metal Batteries: Recent Progress and Perspectives
Authors: Zhang Hangyu , Xu Xijun , Fan Weizhen , Zhao Jingwei , Huo Yanping 
Published: October 2024

AbstractIn pursuit of high energy density, lithium metal batteries (LMBs) are undoubtedly the best choice. However, leakage and inevitable dendrite growth in liquid electrolytes seriously hinder its practical application. Solid/quasi‐solid state electrolytes have emerged as an answer to solve the above issues. Especially, polymer electrolytes with excellent interface compatibility, high flexibility, and ease of machining have become a research hotspot for LMBs. Nevertheless, the interface contact between polymer electrolyte and inorganic electrode materials and the low ionic conductivity restrict its development. On account of these, in situ polymerized polymer electrolyte is proposed. Polymer solid electrolytes produced through in situ polymerization promote robust interface contact between the electrolyte and electrode while simplifying the preparation steps. This review summarized the latest research progress in in situ polymerized solid electrolytes for LMBs. These electrolytes were divided into three parts according to their polymerization methods: thermally induced polymerization, chemical initiator polymerization, ionizing radiation polymerization, and so on. Furthermore, we concluded the major challenges and future trends of in situ polymerized solid electrolytes for LMBs. It's hoped that this review will provide meaningful guidance on designing high‐performance polymer solid electrolytes for LMBs.
Pro‐aromatic Natural Terpenes as Unusual “Slingshot” Antioxidants with Promising Ferroptosis Inhibition Activity
Authors: Jin Zongxin , Mollica Fabio , Huang Yeqin , Guernelli Susanna , Baschieri Andrea , Diquigiovanni Chiara , Rizzardi Nicola , Valenti Francesca , Pincigher Luca , Bergamini Christian , Amorati Riccardo 
Published: October 2024

AbstractFerroptosis is a cell death mechanism based on extensive cellular membrane peroxidation, implicated in neurodegenerative and other diseases. The essential oil component γ‐terpinene, a natural monoterpene with a unique highly oxidizable pro‐aromatic 1,4‐cyclohexadiene skeleton, inhibits peroxidation of polyunsaturated lipid in model heterogeneous systems (micelles and liposomes). Upon H‐atom abstraction, an unstable γ‐terpinene‐derived peroxyl radical is formed, that aromatizes to p‐cymene generating HOO⋅ radicals. As HOO⋅ are small and hydrophilic radicals, they quickly diffuse outside the lipid core, blocking the radical chain propagation of polyunsaturated lipids. This unprecedented antioxidant “slingshot” mechanism explains why γ‐terpinene shows a protective activity against ferroptosis, being effective at submicromolar concentrations in human neuroblastoma (SH‐SY5Y) cells.
Adipocyte‐Targeted Nanotechnology and Cell‐Based Therapy for Obesity Treatment
Authors: Wu Yue , Deng Siqi , Wei Siyu , Wei Wenqi , He Yunxiang , Guo Junling 
Published: October 2024

AbstractObesity is a critical risk factor for the development of metabolic diseases and is often associated with dysfunctional adipocytes. Prevalent treatments such as lifestyle intervention, pharmacotherapy, and bariatric surgery are often accompanied by adverse side effects and poor patient compliance. Nanotechnology and cell‐based therapy offer innovative approaches for targeted obesity treatments, as they can directly target adipocytes, regulate lipid metabolism, and minimize off‐target effects. Here, we provide an overview of the intricate relationship between adipocytes and obesity, highlighting the potential of nanotechnology and cell‐based therapy in obesity treatment. Additionally, we discuss the advancements of adipose‐derived mesenchymal stem cells (ADMSCs) in obesity progression, including the latest challenges and considerations for developing adipose‐targeted treatments for obesity. The objective is to provide a perspective on the design and development of nanotechnology and cell‐based therapy for treating obesity and related comorbidities.
Reduction of myeloid‐derived suppressor cells in prostate cancer murine models and patients following white button mushroom treatment
Authors: Wang Xiaoqiang , Ma Shoubao , Twardowski Przemyslaw , Lau Clayton , Chan Yin S. , Wong Kelly , Xiao Sai , Wang Jinhui , Wu Xiwei , Frankel Paul , Wilson Timothy G. , Synold Timothy W , Presant Cary , Dorff Tanya , Yu Jianhua , Sadava David , Chen Shiuan 
Published: October 2024

AbstractBackgroundIn a previously reported Phase I trial, we observed therapy‐associated declines in circulating myeloid‐derived suppressor cells (MDSCs) with the administration of white button mushroom (WBM) tablets in prostate cancer (PCa) patients. These observations led us to hypothesise that WBM could mitigate PCa progression by suppressing MDSCs.MethodsWe performed bidirectional translational research to examine the immunomodulatory effects of WBM consumption in both syngeneic murine PCa models and patients with PCa participating in an ongoing randomised Phase II trial (NCT04519879).ResultsIn murine models, WBM treatment significantly suppressed tumour growth with a reduction in both the number and function of MDSCs, which in turn promoted antitumour immune responses mediated by T cells and natural killer (NK) cells. In patients, after consumption of WBM tablets for 3 months, we observed a decline in circulating polymorphonuclear MDSCs (PMN‐MDSCs), along with an increase in cytotoxic CD8+ T and NK cells. Furthermore, single immune cell profiling of peripheral blood from WBM‐treated patients showed suppressed STAT3/IRF1 and TGFβ signalling in circulating PMN‐MDSCs. Subclusters of PMN‐MDSCs presented transcriptional profiles associated with responsiveness to fungi, neutrophil chemotaxis, leukocyte aggregation, and regulation of inflammatory response. Finally, in mouse models of PCa, we found that WBM consumption enhanced the anticancer activity of anti‐PD‐1 antibodies, indicating that WBM may be used as an adjuvant therapy with immune checkpoint inhibitors.ConclusionOur results from PCa murine models and patients provide mechanistic insights into the immunomodulatory effects of WBM and provide a scientific foundation for WBM as a nutraceutical intervention to delay or prevent PCa progression.Highlights
White button mushroom (WBM) treatment resulted in a reduction in pro‐tumoural MDSCs, notably polymorphonuclear MDSCs (PMN‐MDSCs), along with activation of anti‐tumoural T and NK cells.
Human single immune cell gene expression profiling shed light on the molecular alterations induced by WBM, specifically on PMN‐MDSCs.
A proof‐of‐concept study combining WBM with PD‐1 blockade in murine models revealed an additive effect on tumour regression and survival outcomes, highlighting the clinical relevance of WBM in cancer management.
Fine Needle Aspiration Cytology of Pancreatoblastoma in Adult/Adolescent Patients, One With Histology Mimicking NUT Carcinoma
Authors: Xu Zhengfan , Aryal Sameer Chhetri , McHugh Kelsey , Theisen Brian K. , Yuan Lisi 
Published: October 2024

ABSTRACTPancreatoblastoma is a rare malignant neoplasm. Cytologic diagnosis is challenging due to the tumor's heterogeneity and requirement of the presence of squamoid nests. Commonly affects children, but the tumor rarely is seen in adult patients. We are reporting three cases from two patients. First patient was a 38‐year‐old male with a mass in the pancreatic body and numerous hepatic lesions. Fine‐needle aspiration (FNA) of the pancreas showed a biphasic malignancy, predominantly composed of a primitive component with intermingled squamoid nests. Subsequent Liver FNA from the same patient showed a similar biphasic malignancy. NUT carcinoma was the top differential and was ruled out by molecular testing. Second patient was a 24‐year‐old female with a history of pancreatoblastoma related to Gardner's syndrome initially diagnosed in 2015 at age 17, status post distal pancreatectomy and chemotherapy. Celiac lymph node FNA in 2021 showed few cohesive clusters of atypical epithelioid cells, which were highlighted by beta‐catenin. Lastly, the literature was reviewed; differential diagnosis and ancillary testing were discussed.
Marine reserves can buffer against environmental fluctuations for overexploited but not sustainably harvested fisheries
Authors: White J. Wilson , Kilduff D. Patrick , Hastings Alan , Botsford Louis W. 
Published: October 2024

AbstractGlobally, decision‐makers are seeking management levers that can mitigate the negative effects of climate change on ecosystems that have already been transformed from their natural state by the effects of fishing. An important question is whether marine reserves can provide buffering (i.e., population‐level resilience) against climate disturbances to fished populations. Here, we examine one aspect of this question, by asking whether marine reserves can reduce the variability in either overall biomass or in fishery yield, in the face of environmental variability. This could happen because greater reproduction of longer‐lived, larger fish inside reserves could supplement recruitment to the fished portion of the population. We addressed this question using age‐structured population models, assuming a system where some proportion of the coastline is protected in marine reserves (0%–30%), and the remainder is fished (at a range of possible harvest rates). We modeled populations with sedentary adults and dispersal via a larval pool. Since recent extreme climate events (e.g., marine heatwaves) have reduced juvenile survival for some fish species, we assumed that environmental variability affected the survival of the first age class in our model. We viewed population variability as a question of buffering, measured as the proportion of time a simulated population spent below a target reference point, with the idea that marine reserves could prevent the population from reaching low levels in the face of fishing and environmental variability. We found that fisheries with more area in marine reserves always had less variability in biomass. However, adding marine reserves only reduced variability in fisheries yield when the fished part of the population was being harvested at a rate exceeding the maximum sustainable yield. This new result on reducing variability is in line with previous findings that the “spillover” effects of marine reserve benefits to fishery yields only accrue when the fishery outside reserve boundaries is being overharvested.