bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alterations in wheat pollen lipidome during high day and night temperature stress
Authors: Narayanan Sruthi , Prasad P.V. Vara , Welti Ruth 
Published: January 2018

AbstractUnderstanding the adaptive changes in wheat pollen lipidome under high temperature (HT) stress is critical to improving seed set and developing HT tolerant wheat varieties. We measured 89 pollen lipid species under optimum and high day and/or night temperatures using electrospray ionization‐tandem mass spectrometry in wheat plants. The pollen lipidome had a distinct composition compared with that of leaves. Unlike in leaves, 34:3 and 36:6 species dominated the composition of extraplastidic phospholipids in pollen under optimum and HT conditions. The most HT‐responsive lipids were extraplastidic phospholipids, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol, phosphatidic acid, and phosphatidylserine. The unsaturation levels of the extraplastidic phospholipids decreased through the decreases in the levels of 18:3 and increases in the levels of 16:0, 18:0, 18:1, and 18:2 acyl chains. PC and PE were negatively correlated. Higher PC:PE at HT indicated possible PE‐to‐PC conversion, lower PE formation, or increased PE degradation, relative to PC. Correlation analysis revealed lipids experiencing coordinated metabolism under HT and confirmed the HT responsiveness of extraplastidic phospholipids. Comparison of the present results on wheat pollen with results of our previous research on wheat leaves suggests that similar lipid changes contribute to HT adaptation in both leaves and pollen, though the lipidomes have inherently distinct compositions.
The behavioral immune system: Current concerns and future directions
Authors: Ackerman Joshua M. , Hill Sarah E. , Murray Damian R. 
Published: January 2018

AbstractThe behavioral immune system is a motivational system that helps minimize infection risk by changing cognition, affect, and behavior in ways that promote pathogen avoidance. In the current paper, we review foundational concepts of the behavioral immune system and provide a brief summary of recent social psychological research on this topic. Next, we highlight current conceptual and empirical limitations of this work and delineate important questions that have the potential to drive major advances in the field. These questions include predicting the ontological development of the behavioral immune system, specifying the relationship between this system and the physiological immune system, and distinguishing conditions that elicit direct effects of situational pathogen threats versus effects that occur only in interaction with dispositional disease concerns. This discussion highlights significant challenges and underexplored topics to be addressed by the next generation of behavioral immune system research.
The Food Outlook: A World Imperative
Authors: Eastwood Ralph A. 
Published: January 2018

Population has proved its propensity to grow faster than its food supply until a balance is reached at the Asiatic level of subsistence. The less-developed countries continue in nutritional crisis largely because of inadequate application of food production technology and the resource requirements imposed by child dependency. Developed countries show much more promise of avoiding this tragedy through management of resources and populations.
Increases are essential in research, teaching and extension education in the many competencies comprising the technologies of food production and public health if food supply is to gain on population. Mechanical engineers must lead if that technology is to be applied through mechanization to bring about desired increases in the economy, efficiency and effectiveness of the food industry, so people may heed their nutritional history and not relive it.
Paper published with permission.
Centralized Control Techniques for the Citrus Concentrating Plant
Authors: Stephenson Ed 
Published: January 2018

There is a strong tendency within the citrus industry to regard the citrus concentrating plant as being a series of discrete operations. From the viewpoint of the instrument engineer the process is a continuous one, incorporating three major dead time areas:
(a) the fruit bins,
(b) the surge (evaporator feed) tanks, and
(c) the tank farm
At all other points in the process the product can be treated as a continuous flow.
Paper published with permission.
Citrus in Brazil
Authors: Mayer Peter C. 
Published: January 2018

The Citrus Engineering Conference Committee of the American Society of Mechanical Engineers is to be commended in choosing this timely subject, Citrus in Brazil.
As most of you know, and as this paper will confirm, Brazil is second only to Florida in the production of frozen concentrated orange juice.
One of the essential components of an effective marketing program is to know your competition so that effective strategies may be developed.
The purpose of this presentation is to give you an overview of citrus in Brazil and its relationship to the Florida industry.
Paper published with permission.
Condensate Reuse: Phase II
Authors: Hamilton Richard A. 
Published: January 2018

During the 1976 edition of the Citrus Engineering Conference, Mr. Dave Hamrick, Technical Vice President of Tropicana Products, delivered a paper entitled “Condensate Reuse in Citrus Plants”. In this paper, he described the nature and composition of process condensate, showed the quantity which might be available for reuse, and recommended several areas where this water might be used.
Paper published with permission.
Florida’s Revised Water Quality Regulations
Authors: Bottcher John G. 
Published: January 2018

On March 1, 1979 revisions to the Florida water quality regulations became effective. These revisions reflect over five years of work and comprise the first major modification to the regulations in their ten year history. Minor modifications have occurred sporadically throughout this time and will continue. Other parts have been challenged in court and further modifications, as a result, are a possibility. Also, as the department gains experience in implementing the rules and new scientific evidence indicates a need for a change, other modifications will be proposed. So it seems that these rules along with most other environmental standards are in a constant state of flux — changes being considered even before the ink drys on the last change.
Paper published with permission.
Chlorine Dioxide: An Effective Biocide for Recycled or Reused Water Systems
Authors: Synan John F. 
Published: January 2018

The desire and indeed the need of industry to recycle or reuse process waters wherever possible is becoming increasingly more urgent. Limited supplies of quality water in many parts of the country and more stringent EPA regulations for waste disposal and water discharge are but two of the many reasons for this.
Paper published with permission.
Human service work, gender and antidepressant use: a nationwide register-based 19-year follow-up of 752 683 women and men
Authors: Buscariolli André , Kouvonen Anne , Kokkinen Lauri , Halonen Jaana I , Koskinen Aki , Väänänen Ari 
Published: January 2018

ObjectivesTo examine antidepressant use among male and female human service professionals.MethodsA random sample of individuals between 25 years and 54 years of age (n=752 683; 49.2% women; mean age 39.5 years). Information about each individual’s filled antidepressant prescriptions from 1995 to 2014 was provided by the Social Insurance Institution. First, antidepressant use in five broad human service categories was compared with that in all other occupations grouped together, separately for men and women. Then, each of the 15 human service professions were compared with all other occupations from the same skill/education level (excluding other human services professions). Cox models were applied and the results are presented as HRs for antidepressant use with 95% CIs.ResultsThe hazard of antidepressant use was higher among men working in human service versus all other occupations with the same skill/occupational level (1.22, 95% CI 1.18 to 1.27), but this was not the case for women (0.99, 95% CI 0.98 to 1.01). The risks differed between professions: male health and social care professionals (including medical doctors, nurses, practical nurses and home care assistants), social workers, childcare workers, teachers and psychologists had a higher risk of antidepressant use than men in non-human service occupations, whereas customer clerks had a lower risk.ConclusionsMale human service professionals had a higher risk of antidepressant use than men working in non-human service occupations. Gendered sociocultural norms and values related to specific occupations as well as occupational selection may be the cause of the elevated risk.
Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity after chronic hypoxia
Authors: Weise-Cross Laura , Sands Michelle A. , Sheak Joshua R. , Broughton Brad R. S. , Snow Jessica B. , Gonzalez Bosc Laura V. , Jernigan Nikki L. , Walker Benjimen R. , Resta Thomas C. 
Published: January 2018

Chronic hypoxia (CH) augments basal and endothelin-1 (ET-1)-induced pulmonary vasoconstrictor reactivity through reactive oxygen species (ROS) generation and RhoA/Rho kinase (ROCK)-dependent myofilament Ca2+ sensitization. Because ROCK promotes actin polymerization and the actin cytoskeleton regulates smooth muscle tension, we hypothesized that actin polymerization is required for enhanced basal and ET-1-dependent vasoconstriction after CH. To test this hypothesis, both end points were monitored in pressurized, endothelium-disrupted pulmonary arteries (fourth-fifth order) from control and CH (4 wk at 0.5 atm) rats. The actin polymerization inhibitors cytochalasin and latrunculin attenuated both basal and ET-1-induced vasoconstriction only in CH vessels. To test whether CH directly alters the arterial actin profile, we measured filamentous actin (F-actin)-to-globular actin (G-actin) ratios by fluorescent labeling of F-actin and G-actin in fixed pulmonary arteries and actin sedimentation assays using homogenized pulmonary artery lysates. We observed no difference in actin polymerization between groups under baseline conditions, but ET-1 enhanced actin polymerization in pulmonary arteries from CH rats. This response was blunted by the ROS scavenger tiron, the ROCK inhibitor fasudil, and the mDia (RhoA effector) inhibitor small-molecule inhibitor of formin homology domain 2. Immunoblot analysis revealed an effect of CH to increase both phosphorylated (inactive) and total levels of the actin disassembly factor cofilin but not phosphorylated cofilin-to-total cofilin ratios. We conclude that actin polymerization contributes to increased basal pulmonary arterial constriction and ET-1-induced vasoconstrictor reactivity after CH in a ROS- and ROCK-dependent manner. Our results further suggest that enhanced ET-1-mediated actin polymerization after CH is dependent on mDia but independent of changes in the phosphorylated cofilin-to-total cofilin ratio. NEW & NOTEWORTHY This research is the first to demonstrate a role for actin polymerization in chronic hypoxia-induced basal pulmonary arterial constriction and enhanced agonist-induced vasoconstrictor activity. These results suggest that a reactive oxygen species-Rho kinase-actin polymerization signaling pathway mediates this response and may provide a mechanistic basis for the vasoconstrictor component of pulmonary hypertension.
miR-508 Defines the Stem-like/Mesenchymal Subtype in Colorectal Cancer
Authors: Yan Ting-Ting , Ren Lin-Lin , Shen Chao-Qin , Wang Zhen-Hua , Yu Ya-Nan , Liang Qian , Tang Jia-Yin , Chen Ying-Xuan , Sun Dan-Feng , Zgodzinski Witold , Majewski Marek , Radwan Piotr , Kryczek Ilona , Zhong Ming , Chen Jinxian , Liu Qiang , Zou Weiping , Chen Hao-Yan , Hong Jie , Fang Jing-Yuan 
Published: January 2018

Abstract
Colorectal cancer includes an invasive stem-like/mesenchymal subtype, but its genetic drivers, functional, and clinical relevance are uncharacterized. Here we report the definition of an altered miRNA signature defining this subtype that includes a major genomic loss of miR-508. Mechanistic investigations showed that this miRNA affected the expression of cadherin CDH1 and the transcription factors ZEB1, SALL4, and BMI1. Loss of miR-508 in colorectal cancer was associated with upregulation of the novel hypoxia-induced long noncoding RNA AK000053. Ectopic expression of miR-508 in colorectal cancer cells blunted epithelial-to-mesenchymal transition (EMT), stemness, migration, and invasive capacity in vitro and in vivo. In clinical colorectal cancer specimens, expression of miR-508 negatively correlated with stemness and EMT-associated gene expression and positively correlated with patient survival. Overall, our results showed that miR-508 is a key functional determinant of the stem-like/mesenchymal colorectal cancer subtype and a candidate therapeutic target for its treatment.
Significance: These results define a key functional determinant of a stem-like/mesenchymal subtype of colorectal cancers and a candidate therapeutic target for its treatment. Cancer Res; 78(7); 1751–65. ©2018 AACR.
Forkhead Box F2 Suppresses Gastric Cancer through a Novel FOXF2–IRF2BPL–β-Catenin Signaling Axis
Authors: Higashimori Akira , Dong Yujuan , Zhang Yanquan , Kang Wei , Nakatsu Geicho , Ng Simon S.M. , Arakawa Tetsuo , Sung Joseph J.Y. , Chan Francis K.L. , Yu Jun 
Published: January 2018

Abstract
DNA methylation has been identified as a hallmark of gastric cancer (GC). Identifying genes that are repressed by DNA promoter methylation is essential in providing insights into the molecular pathogenesis of gastric cancer. Using genome-wide methylation studies, we identified that transcription factor forkhead box F2 (FOXF2) was preferentially methylated in gastric cancer. We then investigated the functional significance and clinical implication of FOXF2 in gastric cancer. FOXF2 was silenced in gastric cancer cell lines and cancer tissues by promoter methylation, which was negatively associated with mRNA expression. Ectopic expression of FOXF2 inhibited proliferation, colony formation, G1–S cell-cycle transition, induced apoptosis of gastric cancer cell lines, and suppressed growth of xenograft tumors in nude mice; knockdown of FOXF2 elicited opposing effects. FOXF2 inhibited Wnt signaling by inducing β-catenin protein ubiquitination and degradation independently of GSK-3β. FOXF2 directly bound the promoter of E3 ligase interferon regulatory factor 2-binding protein-like (IRF2BPL) and induced its transcriptional expression. IRF2BPL in turn interacted with β-catenin, increasing its ubiquitination and degradation. Multivariate Cox regression analysis identified FOXF2 hypermethylation as an independent prognostic factor of poor survival in early-stage gastric cancer patients. In conclusion, FOXF2 is a critical tumor suppressor in gastric carcinogenesis whose methylation status serves as an independent prognostic factor for gastric cancer patients.
Significance: FOXF2-mediated upregulation of the E3 ligase IRF2BPL drives ubiquitylation and degradation of β-catenin in gastric cancer, blunting Wnt signaling and suppressing carcinogenesis. Cancer Res; 78(7); 1643–56. ©2018 AACR.
Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer
Authors: Li Lifeng , Wang Liping , Li Jieyao , Fan Zhirui , Yang Li , Zhang Zhen , Zhang Chaoqi , Yue Dongli , Qin Guohui , Zhang Tengfei , Li Feng , Chen Xinfeng , Ping Yu , Wang Dan , Gao Qun , He Qianyi , Huang Lan , Li Hong , Huang Jianmin , Zhao Xuan , Xue Wenhua , Sun Zhi , Lu Jingli , Yu Jane J. , Zhao Jie , Zhang Bin , Zhang Yi 
Published: January 2018

Abstract
Metformin is a broadly prescribed drug for type 2 diabetes that exerts antitumor activity, yet the mechanisms underlying this activity remain unclear. We show here that metformin treatment blocks the suppressive function of myeloid-derived suppressor cells (MDSC) in patients with ovarian cancer by downregulating the expression and ectoenzymatic activity of CD39 and CD73 on monocytic and polymononuclear MDSC subsets. Metformin triggered activation of AMP-activated protein kinase α and subsequently suppressed hypoxia-inducible factor α, which was critical for induction of CD39/CD73 expression in MDSC. Furthermore, metformin treatment correlated with longer overall survival in diabetic patients with ovarian cancer, which was accompanied by a metformin-induced reduction in the frequency of circulating CD39+CD73+ MDSC and a concomitant increase in the antitumor activities of circulating CD8+ T cells. Our results highlight a direct effect of metformin on MDSC and suggest that metformin may yield clinical benefit through improvement of antitumor T-cell immunity by dampening CD39/CD73-dependent MDSC immunosuppression in ovarian cancer patients.
Significance: The antitumor activity of an antidiabetes drug is attributable to reduced immunosuppressive activity of myeloid-derived tumor suppressor cells. Cancer Res; 78(7); 1779–91. ©2018 AACR.
The Strategy of PIKing a Target: What Is AKTually Most Effective?
Authors: Costa Carlotta , Bosch Ana 
Published: January 2018

Abstract
Breast and gynecologic cancers harboring PIK3CA mutations showed no significant responses to AZD5363, a pan-AKT catalytic inhibitor, in contrast with previous in vitro data showing activity of the drug in this subset of cancers. These results raise the question of how to select the most accurate predictive biomarkers of response. Clin Cancer Res; 24(9); 2029–31. ©2018 AACR.
See related article by Banerji et al., p. 2050
The Antigen ASB4 on Cancer Stem Cells Serves as a Target for CTL Immunotherapy of Colorectal Cancer
Authors: Miyamoto Sho , Kochin Vitaly , Kanaseki Takayuki , Hongo Ayumi , Tokita Serina , Kikuchi Yasuhiro , Takaya Akari , Hirohashi Yoshihiko , Tsukahara Tomohide , Terui Takeshi , Ishitani Kunihiko , Hata Fumitake , Takemasa Ichiro , Miyazaki Akihiro , Hiratsuka Hiroyoshi , Sato Noriyuki , Torigoe Toshihiko 
Published: January 2018

AbstractColorectal cancer consists of a small number of cancer stem cells (CSC) and many non-CSCs. Although rare in number, CSCs are a target for cancer therapy, because they survive conventional chemo- and radiotherapies and perpetuate tumor formation in vivo. In this study, we conducted an HLA ligandome analysis to survey HLA-A24 peptides displayed by CSCs and non-CSCs of colorectal cancer. The analysis identified an antigen, ASB4, which was processed and presented by a CSC subset but not by non-CSCs. The ASB4 gene was expressed in CSCs of colorectal cancer, but not in cells that had differentiated into non-CSCs. Because ASB4 was not expressed by normal tissues, its peptide epitope elicited CD8+ cytotoxic T-cell (CTL) responses, which lysed CSCs of colorectal cancer and left non-CSCs intact. Therefore, ASB4 is a tumor-associated antigen that can elicit CTL responses specific to CSCs and can discriminate between two cellular subsets of colorectal cancer. Adoptively transferred CTLs specific for the CSC antigen ASB4 could infiltrate implanted colorectal cancer cell tumors and effectively prevented tumor growth in a mouse model. As the cancer cells implanted in these mice contained very few CSCs, the elimination of a CSC subset could be the condition necessary and sufficient to control tumor formation in vivo. These results suggest that CTL-based immunotherapies against colorectal CSCs might be useful for preventing relapses. Cancer Immunol Res; 6(3); 358–69. ©2018 AACR.
РЕАБІЛІТАЦІЯ ХВОРИХ ІЗ ОСТЕОХОНДРОЗОМ ХРЕБТА
Authors: Popovych D. V. , Koval V. B. , Salayda I. M. , Vajda O. V. , Rutska A. V. 
Published: January 2018

Вступ Надання кваліфікованої допомоги Хворов при наявності у них неврологічніх проявів вертебрального остеохондрозу (ВО) є однією з остаточно НЕ вірішеніх, найбільш складних та багатоплановіх проблем сучасної науки, а отже, важлівім завдання сучасної медичної РЕАБІЛІТАЦІЇ.Мета дослідження : Візначіті ефективність впліву ЗАСОБІВ фізичної РЕАБІЛІТАЦІЇ комплексного! Застосування удосконалення методик лікувального масажу комплексу лікувальної гімнастікі статико-дінамічніх вправо та вправо на дошці Євмінова на Хворов з остеохондрозом шийно-грудного відділу хребта.Матеріали и методи Обстежено 50 пацієнтів ВІКОМ від 25 до 55 років, Які проходили обстеження и лікування в університетській лікарні.Хворі розподілені на 2 групи: контрольну та експериментальну. Во время дослідження Використано різноманітні методи дослідження стану опорно-рухової системи - ортопедичне и неврологічне обстеження, что включало як суб'єктивні методи дослідження (Скарги, анамнез), так и об'єктивні методи дослідження (огляд, пальпаторно обстеження, діагностика зон шкірної гіперестезії, тригерних зон та функціональніх блокад хребтових-рухового сегментів).Результати ДОСЛІДЖЕНЬ та їх Обговорення. В обох групах у залежності від віку, характеру, локалізації и стадії захворювання, інтенсівності больового синдрому, актівності процесса, симптоматики, супутніх захворювань Хворі пройшли курс фізичної РЕАБІЛІТАЦІЇ. А в експеріментальній групі, разом з комплексом лікувальної гімнастікі статико-дінамічніх вправо, як и в основній групі, додатково застосовувалісь лікувальний масаж, вправі на дошці Євмінова.Висновки . Аналіз безпосередніх результатів лікування довів, что комплексна система виявило більш ефективного у знікненні або зменшенні больового та міотонічного сіндромів, поліпшенні функціонального стану хребта, стану психо-емоційної сфери, підвіщенні якості життя пацієнтів.
АКТУАЛЬНІСТЬ ВІКОВОГО АСПЕКТА КЛІНІЧНОГО ПЕРЕБІГУ І ВЕДЕННЯ ХВОРИХ НА ХРОНІЧНИЙ ПАНКРЕАТИТ (ОГЛЯД ЛІТЕРАТУРИ)
Authors: Babinets L. S. , Shevchenko N. A. 
Published: January 2018

За останні роки спостерігається чітке зростання поширеності патології ПЗ в осіб молодого працездатного віку, однак загострення хронічного процесу у разі «сприятливих умов» відбувається у всіх вікових категоріях. У статті проаналізовано останні літературні дані щодо розповсюдженості, клініко-патогенетичних особливостей найбільш розповсюджених різних за етіологічним чинником форм хронічного панкреатиту з урахуванням вікових груп пацієнтів. Доведено актуальність поглибленого вивчення вікових аспектів хронічного панкреатиту, встановлення клініко-патогенетичних особливостей різних вікових груп хворих, а також розробки на основі цього алгоритмів ведення пацієнтів з хронічним панкреатитом і коморбідними станами із урахуванням встановлених вікових особливостей.Сучасні тенденції медицини і суспільного життя в Україні - впровадження низки реформ на державному рівні щодо збільшення пенсійного віку людей, «помолодшання» і переважання людей працездатного віку серед хворих на хронічний панкреатит, наявність великої кількості коморбідних станів у хворих похилого віку на хронічний панкреатит, виявлення нових невивчених етіологічних форм хронічного панкреатиту та їх вікових особливостей та ін. – роблять актуальною проблему поглибленого вивчення вікових аспектів хронічного панкреатиту, встановлення клініко-патогенетичних особливостей різних вікових груп хворих, а також розробку на основі цього алгоритмів ведення пацієнтів з хронічним панкреатитом і коморбідними станами із урахуванням встановлених вікових особливостей.