bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mothers' Mobility after Separation: Do Grandmothers Matter?
Authors: Das Marjolijn , de Valk Helga , Merz Eva‐Maria 
Published: January 2016

AbstractStarting from a life course perspective, this study aims to gain more insight into mobility patterns of recently separated mothers, focusing especially on moves to the location of their own mother: the maternal grandmother. Separated mothers, having linked lives with their own mothers, may benefit from their practical and emotional support. Additionally, the grandparents' home can be a (temporary) place to stay shortly after divorce. Data come from the System of social statistical datasets (Statistics Netherlands). This unique dataset combines longitudinal data from a vast number of administrative registers. It covers the complete Dutch population, making it exceptionally well suited for life course and mobility research. We studied mothers with minor children between 1/1/2008 and 31/12/2010. Our study included 579,500 mothers, of whom about 8,800 (1.5%) experienced a separation in 2008. Separated mothers moved to the grandmother's municipality more often than non‐separated mothers, which might be partially motivated by the need for childcare. They also coresided with the grandmother more than non‐separated movers, mostly because of a vulnerable socio‐economic position. Although often temporary, coresidence appears to have a prolonged impact on the mothers' location choice; mothers frequently stayed in the grandmother's municipality after moving out. Finally, our results indicated that some mothers seemed to use the parental home as a stepping stone to cohabit with a new partner. © 2016 The Authors. Population, Space and Place published by John Wiley & Sons Ltd.
Alkoxide bridged Copper(II) Hinokitiolato and Tropolonato Complexes: Polymorphism, Reconstructive Phase Transition, and Magnetic Properties
Authors: Schnitzler Silvia , Lamberts Kevin , Speldrich Manfred , Kögerler Paul , Englert Ulli 
Published: January 2016

AbstractPolymorphism and an unexpected reconstructive phase transition in [Cu(trop)(μ‐OMe)]2 (trop = tropolonate) were studied by single crystal and powder X‐ray diffraction; the phase transition is associated with a huge hysteresis of ca. 200 °C. In the readily reproducible crystal form, the methoxide‐bridged dinuclear subunits aggregate to infinite chains by longer bonds in the Jahn‐Teller distorted coordination sphere. Analogous alkoxide‐bridged derivatives with the substituted ligand hinokitiol (hino), [Cu(hino)(μ‐OR)]2 (R = Me, Et, iPr) form pairs of dinuclear complexes and aggregate to discrete tetranuclear molecules. The inter‐cation distance patterns are reflected in the magnetic properties of these two structure types: Strong antiferromagnetic coupling within the dinuclear subunits is observed in either case, but susceptibility measurements confirm differences in exchange coupling between neighboring central CuII atoms.
On the Crystal Structure of a Previously Unknown Anhydrous Zinc Hydroxide Sulfate
Authors: Germann Luzia S. , Dinnebier Robert E. , Liu Xin , Dong Yaping , Li Wu 
Published: January 2016

AbstractAnhydrous zinc hydroxide sulfates are promising precursors for the preparation of pigments and ZnO nanomaterials. The crystal structure of one such compound 5[Zn(OH)2]·2[ZnSO4] was determined from high resolution laboratory X‐ray powder diffraction data by use of a combination of charge flipping,18 simulated annealing,26 and difference Fourier analysis. The material crystallizes in the space group P with the lattice parameters of a = 5.4559(2) Å, b = 8.0528(3) Å, c = 8.9275(3) Å, α = 112.697(2)°, β = 85.219(3)°, γ = 95.441(3)°, and a volume of V = 359.76(2) Å3. The basic crystal structure consists of brucite type Zn(OH)2 layers where every sixth octahedral site is vacant. Tetrahedrally coordinated zinc ions are located above and below these vacancies and consecutive layers are bridged by sulfate molecules. The composition of this layered structure can be written as [Zn5VI□(OH)4·Zn2IV(OH)6·(SO4)2]. Its thermal decomposition was studied by X‐ray powder diffraction and thermal analysis.
Influence of methanol/sorbitol co-feeding rate on pAOX1 induction in a Pichia pastoris Mut+ strain in bioreactor with limited oxygen transfer rate
Authors: Carly F , Niu H , Delvigne F , Fickers P 
Published: January 2016

Abstract
High Pichia pastoris biomass density could be obtained using high co-feeding rate of methanol and sorbitol in a fed-batch or continuous culture, while further higher feeding rate finally leads to oxygen limitation in bioreactor. In the literature, there is lack of report about AOX1 promoter regulation with regard to dissolved oxygen level (DO). Therefore, in this work, chemostat cultures were performed to investigate the cell growth, metabolism and regulation of the AOX1 promoter (pAOX1) regarding co-feeding rate of optimized methanol/sorbitol mixture (methanol fraction 0.60 C-mol/C-mol) using a P. pastoris Mut+/pAOX1-lacZ strain. The oxygen transfer rates (OTR) in bioreactor were kept in the range of typical values of large bioreactor, i.e., 4–8 g/(L h) if DO equals 30 % saturation or 5–10 g/(L h) if DO nears zero. For DO &gt;0, an increase of the carbon fed led to an increase of pAOX1 induction. By contrast, when dissolved oxygen was completely depleted, methanol accumulated, causing a 30 % decrease of pAOX1 induction. However, this decrease is more likely to be lined to methanol accumulation than to low level of dissolved oxygen (&lt;4 % DO). Methanol/sorbitol co-feeding allowed cells to adapt to oxygen transient limitations that often occur at industrial scale with reduced effect on pAOX1 induction. The optimal feeding rate tested here was 6.6 mmol C (DCW h)−1 at an OTR of 8.28 g O2(L h)−1 with over fivefold pAOX1 induction (probably directly associated with target protein productivity) compared with previous work.
High-throughput screening of high Monascus pigment-producing strain based on digital image processing
Authors: Xia Meng-lei , Wang Lan , Yang Zhi-xia , Chen Hong-zhang 
Published: January 2016

Abstract
This work proposed a new method which applied image processing and support vector machine (SVM) for screening of mold strains. Taking Monascus as example, morphological characteristics of Monascus colony were quantified by image processing. And the association between the characteristics and pigment production capability was determined by SVM. On this basis, a highly automated screening strategy was achieved. The accuracy of the proposed strategy is 80.6 %, which is compatible with the existing methods (81.1 % for microplate and 85.4 % for flask). Meanwhile, the screening of 500 colonies only takes 20–30 min, which is the highest rate among all published results. By applying this automated method, 13 strains with high-predicted production were obtained and the best one produced as 2.8-fold (226 U/mL) of pigment and 1.9-fold (51 mg/L) of lovastatin compared with the parent strain. The current study provides us with an effective and promising method for strain improvement.
The yajC gene from Lactobacillus buchneri and Escherichia coli and its role in ethanol tolerance
Authors: Liu Siqing , Skory Chris , Qureshi Nasib , Hughes Stephen 
Published: January 2016

Abstract
The yajC gene (Lbuc_0921) from Lactobacillus buchneri NRRL B-30929 was identified from previous proteomics analyses in response to ethanol treatment. The YajC protein expression was increased by 15-fold in response to 10 % ethanol vs 0 % ethanol. The yajC gene encodes the smaller subunit of the preprotein translocase complex, which interacts with membrane protein SecD and SecF to coordinate protein transport and secretion across cytoplasmic membrane in Escherichia coli. The YajC protein was linked to sensitivity to growth temperatures in E. coli, involved in translocation of virulence factors during Listeria infection, and stimulating a T cell-mediated response of Brucella abortus. In this study, the L. buchneri yajC gene was over-expressed in E. coli. The strain carrying pET28byajC that produces YajC after isopropyl β-d-1-thiogalactopyranoside induction showed tolerance to 4 % ethanol in growth media, compared to the control carrying pET28b. This is the first report linking YajC to ethanol stress and tolerance.
A dose escalating phase I study of GLPG0187, a broad spectrum integrin receptor antagonist, in adult patients with progressive high-grade glioma and other advanced solid malignancies
Authors: Cirkel Geert A. , Kerklaan Bojana Milojkovic , Vanhoutte Frédéric , der Aa Annegret Van , Lorenzon Giocondo , Namour Florence , Pujuguet Philippe , Darquenne Sophie , de Vos Filip Y. F. , Snijders Tom J. , Voest Emile E. , Schellens Jan H. M. , Lolkema Martijn P. 
Published: January 2016

SummaryBackground Integrin signaling is an attractive target for anti-cancer treatment. GLPG0187 is a broad spectrum integrin receptor antagonist (IRA). GLPG0187 inhibited tumor growth and metastasis in mouse models. Methods We aimed to determine the Recommended Phase II Dose (RP2D) and to assess safety and tolerability of continuous i.v. infusion in patients with advanced malignant solid tumors. Anticipated dose levels were 20, 40, 80, 160, 320, and 400 mg/day in a modified 3 + 3 design. Plasma concentrations of GLPG0187 were assessed to characterize the pharmacokinetics (PK). C-terminal telopeptide of type I collagen (CTX) was used as pharmacodynamics marker. Results Twenty patients received GLPG0187. No dose limiting toxicities (DLTs) were observed. The highest possible and tested dose was 400 mg/day. Fatigue was the most frequently reported side effect (25 %). Recurrent Port-A-Cath-related infections and skin toxicity suggest cutaneous integrin inhibition. No dose-dependent toxicity could be established. PK analysis showed a short average distribution (0.16 h) and elimination (3.8 h) half-life. Continuous infusion resulted in dose proportional PK profiles. We observed decreases in serum CTX levels independent of the dose given, suggesting target engagement at the lowest dose level tested. Single agent treatment did not result in tumor responses. Conclusions GLPG0187 was well tolerated with a dose-proportional PK profile upon continuous infusion. No formal maximal tolerated dose could be established. GLPG0187 showed signs of target engagement with a favourable toxicity profile. However, continuous infusion of GLPG0187 failed to show signs of monotherapy efficacy.
Audit of Atypical Femoral Fractures and a Description of Some of Their Features
Authors: Lian Kevin , Trollip Jacques , Sandhu Supna , Moosavi Mandana , Gill Amninder , Kendler David , Dian Larry , Lentle Brian 
Published: January 2016

Purpose Atypical femoral fractures (AFF) are recently described events related to osteoporosis and, potentially, a rare result of antiresorptive treatment. Methods We set out to audit the diagnosis of AFF in an acute hospital. Charts and radiographs were reviewed retrospectively from patients diagnosed with subtrochanteric femoral fractures according to hospital discharge coding at Vancouver General Hospital (VGH), Canada, from January 2005 to March 2013. Results A total of 3084 patients were discharged from the hospital with a diagnosis of hip fracture between 2005 and 2013. Of these, 204 were coded as having had subtrochanteric fractures; 178 of the patients thus coded had radiographic evidence of other fracture types—usually intertrochanteric fractures. Eleven patients did not have available radiographs. Of the remaining 193 patients whose radiographs were reviewed, 24 (12.4%) fulfilled the published criteria for AFF. Our observations were 1) laterality: 13 of 24 AFF (54.2%) were right-sided; 2) there was only one incomplete AFF in this series: a completed fracture was an inclusion criterion, but 1 patient with an AFF had both that fracture and an incomplete fracture and further foci of periosteal or endosteal foci of new bone (PENB) involving the contralateral femur; 3) radiologists had only diagnosed AFF in only 1 of the 24 patients with characteristic radiographic signs of AFF; 4) all but 1 patient had a focus of periosteal and/or endosteal new bone (PENB) through which the fracture line invariably passed, and in the 1 exception the radiography was too poor to be sure of this but there was a symmetrical contralateral focus of PENB; 5) in 19 of 24 patients there was an adequate image of part of the contralateral femur and of these 12 (63%) had a contralateral focus of PENB situated ±2.5 cm from the index lesion site when measured from the upper aspect of the greater trochanter, and in another patient a prior fracture of the contralateral femur had been treated surgically and it was at a symmetrical contralateral location from the index fracture.; 6) in 3 of the 19 patients multiple foci of PENB were detected on the lateral aspect of the contralateral femur even though the examination was of limited extent; and 7) AFFs were associated with bisphosphonate medication in 75% of the patients studied. Conclusions Hospital discharge coding misclassified a great majority of femoral fractures as subtrochanteric. As an essential criteria for diagnosing AFF is their subtrochanteric location, this misclassification impaired our ability to retrospectively search for AFF patients. Radiologists tended not to report AFF when typical radiographic characteristics were present. Bilateral and multifocal disease is of interest in pointing to the diagnosis and in suggesting that the mechanism of injury in respect of these unusual fractures is more complex than simple low-energy trauma.
Review of the feed industry from a historical perspective and implications for its future
Authors: Coffey D. , Dawson K. , Ferket P. , Connolly A. 
Published: January 2016

SummaryThe history of the feed industry is pertinent in terms of understanding how and why certain practices have evolved. Some of these practices have been superseded by modern, more natural alternatives, for example the traditional use of antibiotics in feed. In other cases, such as inorganic minerals, more natural versions akin to those found in plant and animal materials are available, although these new initiatives are still being taken up globally. Research continues to increase our knowledge and understanding of nutrient balance and digestion, and in some species this is more advanced than others. The following paper represents the first complete history of the feed industry, its major milestones, and projects how it might continue to utilise new technology developments to improve animal feeding practices.
Dairy consumption and CVD: a systematic review and meta-analysis
Authors: Alexander Dominik D. , Bylsma Lauren C. , Vargas Ashley J. , Cohen Sarah S. , Doucette Abigail , Mohamed Muhima , Irvin Sarah R. , Miller Paula E. , Watson Heather , Fryzek Jon P. 
Published: January 2016

AbstractInverse associations between dairy consumption and CVD have been reported in several epidemiological studies. Our objective was to conduct a meta-analysis of prospective cohort studies of dairy intake and CVD. A comprehensive literature search was conducted to identify studies that reported risk estimates for total dairy intake, individual dairy products, low/full-fat dairy intake, Ca from dairy sources and CVD, CHD and stroke. Random-effects meta-analyses were used to generate summary relative risk estimates (SRRE) for high v. low intake and stratified intake dose–response analyses. Additional dose–response analyses were performed. Heterogeneity was examined in sub-group and sensitivity analyses. In total, thirty-one unique cohort studies were identified and included in the meta-analysis. Several statistically significant SRRE below 1.0 were observed, namely for total dairy intake and stroke (SRRE=0·91; 95 % CI 0·83, 0·99), cheese intake and CHD (SRRE=0·82; 95 % CI 0·72, 0·93) and stroke (SRRE=0·87; 95 % CI 0·77, 0·99), and Ca from dairy sources and stroke (SRRE=0·69; 95 % CI 0·60, 0·81). However, there was little evidence for inverse dose–response relationships between the dairy variables and CHD and stroke after adjusting for within-study covariance. The results of this meta-analysis of prospective cohort studies have shown that dairy consumption may be associated with reduced risks of CVD, although additional data are needed to more comprehensively examine potential dose–response patterns.
Interactions between retinol,α-tocopherol and cholecalciferol need consideration in diets for farmed mink (Mustela vison)
Authors: Hymøller Lone , Clausen Tove N. , Jensen Søren K. 
Published: January 2016

AbstractA sufficient but balanced vitamin supplementation is a prerequisite for a satisfactory growth pattern and an effective immune system in mink and all other species. The fat-soluble vitamins are very sensitive to over- or under-supply because they interact with each other with respect to dose–response and chemical form. The purpose of the present study was to investigate the effect of increasing the amount of retinol in combination with RRR-α-tocopherol orall-rac-α-tocopherol in the feed given to growing mink on their retinol, cholecalciferol andα-tocopherol concentrations in plasma and selected organs. The results showed that the mink met their retinol requirements from the basal diet, but there were no negative effects of supplying various amounts of retinol on their plasmaα-tocopherol concentrations. On the other hand, the study showed that the cholecalciferol status in plasma, assessed as the 25-hydroxycholecalciferol concentration, was low when retinol was supplemented in the feed at high levels. In addition, supplementation with RRR-α-tocopherol in the feed negatively affected the plasma concentration of 25-hydroxycholecalciferol compared with supplementation withall-rac-α-tocopherol. In general, female mink had higher concentrations of fat-soluble vitamins in plasma than male mink.
When Jews Speak Arabic: Dialectology and Difference in Colonial Morocco
Authors: Kosansky Oren 
Published: January 2016

AbstractThis article explores how Judeo-Arabic and its speaking population were constituted as objects of research and reformation in colonial Morocco. I argue that the colonial project of dialectology, which emphasized the differentiated linguistic terrain of indigenous society, operated at two opposing levels. On one hand, the study of Judeo-Arabic contributed to the idea of homogeneous orality attributed to native languages, which despite their diverse relationships with literate textuality were made to appear divorced from locally established systems of writing. On the other, the historical and affective relationship between Jews and their Arabic dialect was figured in terms that stressed Jewish alienation from their mother tongue and thereby cast native Jews as differentiated objects of francophone linguistic reform. I pay particular attention to the material mechanics of ethnographic methodology, orthographic entextualization, and editorial arrangement through which colonial dialectologists rendered the Jewish dialect as an essentially oral and Arabic dialect, despite the countervailing circulation of Judeo-Arabic texts written in the Hebrew script. This investigation contributes to our understanding of how dialectology operated as a colonial science through which the hierarchical social categories of colonial rule were established, sustained, and manipulated against the backdrop of linguistic practices that never fully conformed to their colonial representation.
Export-Import Theory and the Racialization of Anti-Semitism: Turkish- and Arab-Only Prevention Programs in Germany
Authors: Özyürek Esra 
Published: January 2016

AbstractSince the year 2000, remembering the Holocaust and fighting anti-Semitism have come to be accepted as cornerstones of European identity. The flip side of this development has been racialization of Muslims by singling them out as the main contemporary anti-Semites. After discussing the emergence of the concept “Muslim anti-Semitism,” I scrutinize government-issued reports and anti-Semitism-prevention programs in Germany. I show how the recent wave of struggle against anti-Semitism depicts Muslims as outsiders who bring unwanted ideologies, evaluates their anti-Semitism as more dangerous than that of right-wing German nationals, and attributes to Muslims culturally transmitted psychopathologies that make Muslim nations prone to anti-Semitism. Experts locate the root of Turkish anti-Semitism in their “myth of tolerance toward Jews,” and of Arab anti-Semitism in their sense of a “false victimhood” and “desire for power and pride.” Educators focus on each nationality separately to distinguish these alleged group-specific myths and feelings. Efforts and money that go into producing nation-specific Muslim anti-Semitisms depict a new Germany that has fully liberated itself from any anti-democratic tendencies surviving from its Nazi past. It also obscures connections between anti-Semitism and anti-Muslim racism, both of which are active forces in mainstream German society.
Effects of time and dose of organic fertilizers on soil fertility, nutrient content and yield of vegetables
Authors: HERENCIA J. F. , MAQUEDA C. 
Published: January 2016

SUMMARYA comparative study of the effect of organic fertilization at different times and doses on soil fertility and crop yield was performed over 3 years in a calcareous loamy soil. Nutrient availability in the soil and macronutrient concentration in leaves and in the edible part of the plants was examined in plots that were previously handled conventionally and ecologically for several years. The organic fertilizers used were manure compost at two doses in plots after 4 years of organic management treatment, and green residues of previous crops in plots with 10 years of organic management. In general, soil organic carbon (C), nitrogen (N), phosphorous (P) and magnesium (Mg) contents were found to be considerably greater in organically fertilized soils in comparison with soil receiving mineral fertilizer (conventional treatment (CT)). For C and N, the highest contents were observed in the long-term organic treatment (OR). However, few differences were found for potassium (K) and sodium (Na). The results obtained for electrical conductivity and pH indicated that, in general, there were no significant differences between treatments. The differences in the values of EC and pH occurred among cultivation cycles irrespective of the type of fertilization, but there was a contradictory trend for each of the above parameters. The results obtained for leaves and the edible part of the plant indicated that, in general, there were no significant differences between treatments, except for P with a trend for higher P content in organic crops. The nitrate values in leaves showed great variability, making it difficult to draw conclusions. The associations of fertilization and the chemical properties of soil with nutrient content in crops were checked by principal component analysis (PCA). For soil data, different clusters were observed between CT and OR treatments. However, PCA showed that the influence of crop type on plant nutrient concentrations was greater than type of fertilization. The effect of fertilization on crop yield was variable depending on plant species. The results indicated that organic fertilization did not cause deficiencies in the nutrient content and yield of vegetables when compared with conventional fertilization, showing that ecological management can be used effectively.