bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-machine batch scheduling problem with job rejection and resource dependent processing times
Authors: Huang Weifan , Wu Chin-Chia , Liu Shangchia 
Published: May 2017

This paper addresses single-machine batch scheduling with job rejection and convex resource allocation. A job is either rejected, in which case a rejection penalty will be incurred, or accepted and processed on the machine. The accepted jobs are combined to form batches containing contiguously scheduled jobs. For each batch, a batch-dependent machine setup time, which is a function of the number of batches processed previously, is required before the first job in the batch is processed. Both the setup times and job processing times are controllable by allocating a continuously divisible nonrenewable resource to the jobs. The objective is to determine an accepted job sequence, a rejected job set, a partition of the accepted job sequence into batches, and resource allocation that jointly minimize a cost function based on the total delivery dates of the accepted jobs, and the job holding, resource consumption, and rejection penalties. An dynamic programming solution algorithm with running time O (n6) is developed for the problem. It is also shown that the case of the problem with a common setup time can be solved in O (n5) time.
Vereinbarkeit von Familie und Beruf bei Beschäftigten im Gesundheitswesen als Handlungsfeld der Versorgungsforschung
Authors: Lukasczik Matthias , Ahnert Jutta , Ströbl Veronika , Vogel Heiner , Donath Carolin , Enger Ilka , Gräßel Elmar , Heyelmann Lena , Lux Heidemarie , Maurer Jochen , Özbe Dominik , Spieckenbaum Stefanie , Voigtländer Elzbieta , Wildner Manfred , Zapf Andreas , Zellner Angela , Hollederer Alfons 
Published: May 2017

Zusammenfassung
Hintergrund/Ziele Beschäftigte im Gesundheitswesen sind mit besonderen beruflichen Rahmenbedingungen und Anforderungen konfrontiert, die sich auf das Verhältnis von Familie und Arbeit/Beruf auswirken können und mittelbar auch die Qualität der Gesundheitsversorgung beeinflussen. Ziel des vorliegenden Beitrags ist es, einen Überblick über den Forschungsstand zu diesem Thema zu geben. Dieser ist für die Versorgungsforschung von Relevanz. Er kann als Ausgangspunkt dafür dienen, Strukturen im Gesundheitswesen (auch in ländlichen Regionen) dahingehend zu verändern, dass sie eine bessere Vereinbarkeit von Familie und Beruf ermöglichen.
Methode Es wurde eine systematische nationale und internationale Literaturrecherche in Form eines Scoping Review durchgeführt, um den aktuellen Forschungsstand zur Vereinbarkeit von Familie und Gesundheitsberuf zu dokumentieren. Als inhaltliche Suchkriterien wurden definiert: Vereinbarkeit von Beruf und Familie (allgemein); Vereinbarkeitserleben und -konflikte bei Gesundheitsberufen; Vereinbarkeit von Familie und Gesundheitsberuf im ländlichen Raum; Interventionsansätze zur Förderung der Vereinbarkeit von Beruf und Familie. Im Ergebnis eines mehrstufigen Selektionsprozesses wurden 145 Publikationen in die inhaltliche Auswertung einbezogen.
Ergebnisse Die dokumentierte Literatur bezieht sich schwerpunktmäßig auf die Berufsgruppen Ärzte und beruflich Pflegende, für andere Berufsgruppen liegen kaum Arbeiten vor. Die methodische Qualität der Studien ist meist niedrig, Metaanalysen liegen nicht vor. Mehrere Arbeiten dokumentieren eine Unzufriedenheit bei Ärzten und beruflich Pflegenden bzgl. Möglichkeiten der Vereinbarkeit von Familie und Beruf. Es konnten nur wenige Interventionsstudien zur Förderung der Vereinbarkeit von Familie und Beruf gefunden werden, diese sind wiederum nur teilweise spezifisch auf Gesundheitsberufe ausgerichtet. Defizite bestehen zudem hinsichtlich der Vernetzung mit Fragen der Verbesserung der Gesundheitsversorgung in ländlichen Gebieten.
Schlussfolgerung Zur Thematik „Vereinbarkeit von Familie und Gesundheitsberuf“ existiert national wie international nur wenig systematische Forschung. Insbesondere zur Evaluation von Maßnahmen bestehen Defizite. Der Literaturüberblick ermöglicht die Ableitung von Ansatzpunkten, um eine Verbesserung der Vereinbarkeit von Familie und Beruf zu erreichen.
A Genetic Marker Associated with Shoulder Dislocation
Authors: Kim Stuart , Kleimeyer John , Ahmed Marwa , Avins Andy , Fredericson Michael , Dragoo Jason , Ioannidis John 
Published: May 2017

AbstractShoulder dislocations are common shoulder injuries associated with athletic activity in contact sports, such as football, rugby, wrestling, and hockey. Identifying genetic loci associated with shoulder dislocation could shed light on underlying mechanisms for injury and identify predictive genetic markers. To identify DNA polymorphisms associated with shoulder dislocation, a genome-wide association screen was performed using publically available data from the Research Program in Genes, Environment and Health including 662 cases of shoulder dislocation and 82 602 controls from the European ancestry group. rs12913965 showed an association with shoulder dislocation at genome-wide significance (p=9.7×10−9; odds ratio=1.6) from the European ancestry group. Individuals carrying one copy of the risk allele (T) at rs12913965 showed a 69% increased risk for shoulder dislocation in our cohort. rs12913965 is located within an intron of the TICRR gene, which encodes TOPBP1 interacting checkpoint and replication regulator involved in the cell cycle. rs12913965 is also associated with changes in expression of the ISG20 gene, which encodes an antiviral nuclease induced by interferons. This genetic marker may one day be used to identify athletes with a higher genetic risk for shoulder dislocation. It will be important to replicate this finding in future studies.
Koinzidenz und Therapie von Beinachsdeviationen bei degenerativen Knorpelschäden des Kniegelenks. Ergebnisse aus dem Deutschen KnorpelRegister DGOU
Authors: Spahn Gunter , Fritz Jürgen , Albrecht Dirk , Angele Peter , Fickert Stefan , Aurich Matthias , Hofmann Gunther , Niemeyer Phillip 
Published: May 2017

Zusammenfassung
Zielsetzung Ziel dieser arthroskopischen Multicenterstudie war es, die Koinzidenz von degenerativ bedingten Knorpelschäden mit Varus- oder Valgusfehlstellungen zu bestimmen. Weiterhin war es Ziel, die Häufigkeit von die knorpelregenerativen Eingriffe begleitenden Korrekturoperationen von Varus- oder Valgusfehlstellungen in der deutschen Versorgungsrealität zu ermitteln.
Material und Methode Von insgesamt 1778 Patienten, die zum Stichtag 01.08.2016 im Deutschen KnorpelRegister registriert waren, wurde in 90,9% der Fälle die Beinachse durch den Operateur klinisch und in 56,0% der Fälle durch eine radiologische Messung bestimmt. In die Auswertung wurden insgesamt 614 Patienten mit einem fokalen degenerativ bedingten Knorpelschaden aufgenommen, bei denen präoperativ sowohl eine klinische als auch eine radiologische Beinachsendiagnostik erfolgt war.
Ergebnisse Der durchschnittliche mechanische Tibia-Femur-Winkel nach Paley (mTFA) betrug bei klinisch neutraler Beinachse 0,2° (SD 0,6; 0 – 5), bei klinischem Varus 5,0° (SD 3,2; 0 – 15) und bei klinischem Valgus − 4,7° (SD − 4,0; − 15 – 0). Damit hatten 76,9% der Patienten eine normale Beinachse. Ein Varus wurde in 18,9% und ein Valgus in 4,2% der Fälle bestimmt. Varusfehlstellungen waren häufiger mit Knorpelschäden im medialen und Valgusfehlstellungen häufiger mit Schäden im Bereich des lateralen Kompartiments assoziiert. In 72,4% wurde bei vorliegendem Varus der Knorpeleingriff mit einem zeitnahen Korrektureingriff der Beinachse kombiniert. Beim Vorliegen einer Valgusfehlstellung wurde dies in der Hälfte der Fälle vorgenommen. Auf die Entscheidung des Operateurs zur gleichzeitigen Achskorrektur hatte die Wahl des knorpelregenerativen Verfahrens keinen Einfluss.
Schlussfolgerungen Degenerative Knorpelschäden im Bereich des Kniegelenks sind in etwa einem Viertel der Fälle mit pathologischen Abweichungen der Beinachse (18,9% Varus; 4,2% Valgus) assoziiert. In einem hohen Prozentsatz solcher Fehlstellungen werden durch die Operateure zusätzlich zum knorpelregenerativen Eingriff zeitnah Korrektureingriffe vorgenommen. Dabei ist jedoch bislang unklar, inwieweit dies die Prognose und das Ergebnis beeinflusst.
Salvia plebeia Extract Inhibits Xanthine Oxidase Activity In Vitro and Reduces Serum Uric Acid in an Animal Model of Hyperuricemia
Authors: Kim Jin , Kim Woo , Hyun Jung , Lee Jong , Kwon Jin , Seo Changon , Song Myung-Jin , Choi Chun , Hong Seong , Park Kyuhee , Kim Pansoo , Sung Hachang , Lee Jin , Choi Yongmun 
Published: May 2017

AbstractHyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improved safety and efficacy. Here, we discovered that Salvia plebeia extract inhibited the enzyme activity of xanthine oxidase, which is a key enzyme generating uric acid in the liver. In an animal model of hyperuricemia, S. plebeia extract reduced serum urate to the levels observed in control animals. The urate-lowering effect of S. plebeia extract in vivo was supported by the identification of compounds that inhibit xanthine oxidase enzyme activity in vitro. Nepetin, scutellarein, and luteolin contributed significantly to S. plebeia bioactivity in vitro. These compounds showed the highest potency against xanthine oxidase with IC50 values of 2.35, 1.74, and 1.90 µM, respectively, and were present at moderate quantities. These observations serve as a basis for further elaboration of the S. plebeia extracts for the development of new therapeutics for hyperuricemia and related diseases.
Low temperature nullifies the circadian clock in cyanobacteria through Hopf bifurcation
Authors: Murayama Yoriko , Kori Hiroshi , Oshima Chiaki , Kondo Takao , Iwasaki Hideo , Ito Hiroshi 
Published: May 2017

Significance
Loss of circadian rhythms of poikilotherms or plants occurs widely at low temperatures. Here we chilled the simplest circadian oscillator reconstituted in a test tube and found that a reduction in amplitude abrogated rhythmicity, which transitioned into a damped circadian rhythm oscillator at approximately 19 °C. Physicists in the field of dynamical systems refer to this phenomenon as the Hopf bifurcation. Further, diminished amplitude was restored by resonating with temperature cycles. These results suggest that the amplitude of the cyanobacterial circadian rhythm is sufficiently maintained during periods of cold temperatures through resonating with a periodical environment.
The state and civility: a crucial nexus
Authors: Wickham Gary , Evers Anna Louise Barbara , Goodie Jo-Ann 
Published: May 2017

ABSTRACT
The study of civility is branching out. A wide range of new studies have been published in the last twenty years. While the increase in the diversity of approaches usefully expands the scope of the concept, it is also a cause for concern. Much of the new work pays little attention to civility’s complex history as a practice and simply assumes its fundamental capacity to lead interaction between human beings in a peaceful direction, leaving this body of work in no position to fully appreciate the crucial role of the state. Our main argument here is that civility emerged alongside the modern state in early-modern Europe to form an ongoing state–civility nexus, a nexus by which the state produces and maintains conditions that allow civility to flourish, in turn allowing civility to help the state maintain itself, particularly by restraining the state’s raw power. We pursue this argument by exploring two sets of writings. One set is composed of work by early-modern writers, especially Thomas Hobbes, with some attention paid to four others: Justus Lipsius, Jean Bodin, Samuel Pufendorf, and Christian Thomasius. The second set is composed of work by twentieth-century writers, especially Norbert Elias, with some attention paid to two others: Max Weber and Edward Shils.
Preoperative Ultrasound-Guided Wire Localization of the Lateral Femoral Cutaneous Nerve
Authors: Hanna Amgad S. , Ehlers Mark E. , Lee Kenneth S. 
Published: May 2017

Abstract

BACKGROUND: Difficulty and sometimes inability to find the lateral femoral cutaneous nerve (LFCN) intraoperatively is well known. Variabilities in the course of the nerve are well documented in the literature. In a previous paper, we defined a tight fascial canal that completely surrounds the LFCN in the proximal thigh. These 2 factors sometimes render finding the nerve intraoperatively, to treat meralgia paresthetica, very challenging.

OBJECTIVE: To explore the use of preoperative ultrasound to minimize operative time and eliminate situations in which the nerve is not found.

METHODS: Since 2011, we have used preoperative ultrasound-guided wire localization (USWL) in 19 cases to facilitate finding the nerve intraoperatively. Data were collected prospectively with recording of the timing from skin incision to identifying the LFCN; this will be referred to as the skin-to-nerve time.

RESULTS: In 2 cases, the localization was incorrect. In the 17 cases in which the LFCN was correctly localized, the skin-to-nerve time ranged from 3 min to 19 min. The mean was 8.5 min, and the median was 8 min.

CONCLUSION: Preoperative USWL is a useful technique that minimizes the time needed to find the LFCN. For the less experienced surgeon, it is extremely valuable. For the experienced surgeon, it can identify anatomical abnormalities such as duplicate nerves, which may not be readily recognizable without ultrasound. Collaboration between the surgeon and the radiologist is very important, especially in the early cases.
Tarlov Cyst Causing Sacral Insufficiency Fracture
Authors: Puffer Ross C. , Gates Marcus J. , Copeland William , Krauss William E. , Fogelson Jeremy 
Published: May 2017

Abstract

BACKGROUND AND IMPORTANCE: Tarlov cysts, also known as perineural cysts, have been described as meningeal dilations of the spinal nerve root sheath between the peri- and endoneurium at the dorsal root ganglion. Most often they are found in the sacrum involving the nerve roots. Normally asymptomatic, they have been reported to present with radiculopathy, paresthesias, and even urinary or bowel dysfunction. Sacral insufficiency has not been a well-documented presentation.

CLINICAL PRESENTATION: The patient is a 38-year-old female who started to develop left low back pain and buttock pain that rapidly progressed into severe pain with some radiation down the posterior aspect of her left leg. There was no recent history of spine or pelvic trauma. These symptoms prompted her initial emergency department evaluation, and imaging demonstrated a large Tarlov cyst with an associated sacral insufficiency fracture. She was noted to have a normal neurological examination notable only for an antalgic gait. She was taken to surgery via a posterior approach and the cyst was identified eccentric to the left. The cyst was fenestrated and the nerve roots identified. Given her large area of bone erosion and insufficiency fractures, fixation of the sacroiliac joints was deemed necessary. Fusion was extended to the L5 vertebral body to buttress the fixation. She tolerated the procedure well and was discharged from the hospital on postoperative day 3.

CONCLUSION: Tarlov cysts of the sacrum can lead to significant bone erosion and subsequent insufficiency fractures, requiring fenestration and in some cases, complex sacropelvic fixation.
The Cardiac Rehabilitation Model Improves Fitness, Quality of Life, and Depression in Breast Cancer Survivors
Authors: Dolan Lianne B. , Barry Danielle , Petrella Teresa , Davey Lindsay , Minnes Ann , Yantzi Allison , Marzolini Susan , Oh Paul 
Published: May 2017

Purpose:
Exercise is a demonstrated, therapeutic strategy for cancer survivors to minimize many treatment-induced side effects and may decrease risk of recurrence. Nonetheless, structured programs that combine exercise and education are not yet standardized within cancer care. The Health, Exercise, Active Living, Therapeutic lifestyle (HEALTh) program is a clinical exercise program based on the established cardiac rehabilitation model, but customized for female breast cancer survivors. This study assessed the effects of a cardiac rehabilitation program on cardiorespiratory fitness, quality of life, and depressive symptoms in breast cancer survivors.

Methods:
Charts were reviewed to evaluate the cardiac rehabilitation model. The program consisted of 1 weekly supervised session for 22 group sessions. Each patient was provided with personalized aerobic and resistance exercises plus 12 group educational sessions to encourage behavioral adoption to a healthy lifestyle. Cardiorespiratory fitness (direct

JOURNAL/jcprh/04.03/01273116-201807000-00007/7FSM1/v/2023-09-11T074623Z/r/image-gif

o
2peak), quality of life (Short Form-36 Health Status [SF-36] and Functional Assessment of Cancer Therapy-Breast [FACT-B]), and depression (Centre of Epidemiological Studies Depression [CES-D]) were assessed at baseline and after program completion.

Results:
Two hundred seventy-four files were accessed with 152 eligible files analyzed. Baseline cardiorespiratory fitness and quality-of-life values were below population norms. Program adherence was 66.6%. Cardiorespiratory fitness improved by 14% (21 ± 6 to 24 ± 7 mL/kg/min, P < .001), with significant improvements in quality of life (P < .001) and depression scores (P = .019). Bodily pain was the only domain not significantly affected (P = .311).

Conclusion:
The cardiac rehabilitation model improved physical and mental health in breast cancer survivors. These results provide support for the collaborative effort between cardiology and oncology to improve patient care across the cancer care continuum.
Childhood Trauma and Lifetime Traumatic Brain Injury Among Individuals Who Are Homeless
Authors: Song Michael Jae , Nikoo Mohammadali , Choi Fiona , Schütz Christian G. , Jang Kerry , Krausz Reinhard Michael 
Published: May 2017

Objectives:
To study the association of childhood trauma and lifetime prevalence of traumatic brain injury (TBI) among individuals who are homeless.

Design:
Cross-sectional survey.

Setting:
Three cities in British Columbia, Canada.

Participants:
Five hundred individuals who are homeless and 19 years of age or older in 2009.

Measurements:
Traumatic brain injury was identified with National Survey of Homeless Assistance Providers and Clients (NSHAPC) and childhood trauma using the Childhood Trauma Questionnaire—Short Form (CTQ-SF). The relationship between childhood trauma and TBI was explored using multivariable logistic regression approach, adjusting for age, gender, any psychiatric diagnosis (anxiety disorder, mood disorder, psychosis), alcohol dependence, and substance dependence. The effect of number of childhood trauma types on TBI was also explored using multiple variables logistic regression approach adjusting for the same covariates.

Results:
The prevalence of TBI was 63.6% and childhood maltreatment was 87.7% among the sample population. During childhood of 487 participants included in the analysis, 57.7% experienced physical abuse, 62.8% physical neglect, 45.8% sexual abuse, 62.4% emotional abuse, and 55.2% emotional neglect. After adjustment, childhood trauma (adjusted odds ratio [aOR] = 2.26; 95% confidence interval [CI], 1.04-5.02), childhood physical abuse (aOR = 2.13; 95% CI, 1.19-3.87; n = 487), and childhood emotional abuse (aOR = 1.95; 95% CI, 1.09-3.51; n = 487) were significantly associated with history of TBI. After adjustment, having 4 different types of childhood trauma (aOR = 2.81; 95% CI, 1.11-7.31) was significantly associated with higher odds of reporting TBI history.

Conclusions:
Childhood trauma is significantly associated with lifetime prevalence of TBI in homeless populations in British Columbia, Canada, indicating an added level of vulnerability in this population. In addition, these findings suggest a potential role for childhood trauma prevention strategies and services mindful of the patients' history of trauma for this particularly vulnerable population.
Traumatic Brain Injury and Depression in a Community-Based Sample: A Cohort Study Across the Adult Life Span
Authors: Osborn A. J. , Mathias J. L. , Fairweather-Schmidt A. K. , Anstey K. J. 
Published: May 2017

Objectives:To determine whether self-reported traumatic brain injuries (TBIs) are associated with “cases” of clinically significant depression in the general community. To examine interactions between variables previously linked to depression after a TBI.Setting:Population-based community study (Canberra and Queanbeyan, Australia).Participants and Design:Three age cohorts: young, middle-aged, and older adults (aged 20-24, 40-44, and 60-64 years at baseline) randomly selected from the electoral roll and followed across 3 waves (4 years apart). A total of 7397, 6621, and 6042 people provided their TBI history in waves 1 to 3.Measures:Lifetime (TBIlifetime: sustained at any time since birth), recent (TBIrecent: in the preceding 4 years), and multiple (TBImultiple: more than 1) TBIs, current depression, and known risk factors for depression (age, sex, marital/employment status, prior history of depression, medical conditions, recent life events, alcohol consumption, social support, physical activity).Results:Generalized estimating equations demonstrated a significant association between sustaining a TBI and experiencing clinically significant depression (cases), even after controlling for multiple demographic and health/lifestyle factors.Conclusion:There is an enduring association between depression and TBI, suggesting that, following a TBI, individuals should be monitored and supported to optimize their long-term psychological health.
Anxiety Disorders in Adults With Childhood Traumatic Brain Injury: Evidence of Difficulties More Than 10 Years Postinjury
Authors: Albicini Michelle , McKinlay Audrey 
Published: May 2017

Objective:
To explore long-term psychiatric outcomes in individuals with a history of childhood traumatic brain injury (TBI) or orthopedic injury (OI).

Setting:
Hospital emergency department, medical admission records and outpatient settings.

Participants:
There were 95 males (M = 22.78 years, SD = 3.44 years) and 74 females (M = 22.27 years, SD = 3.09 years), 65 with mild TBI (M = 23.25 years, SD = 3.58 years), 61 with moderate-severe TBI (M = 22.34 years, SD = 2.79 years), and 43 with OI (M = 21.81 years, SD = 3.36 years).

Design:
Longitudinal, between-subjects, cross-sectional design using retrospective and current data.

Main Measures:
Semistructured interview to obtain psychiatric diagnoses and background information, and medical records for identification of TBI.

Results:
Group with moderate-severe TBI presented with significantly higher rates of any anxiety disorder (χ2
2 = 6.81, P = .03) and comorbid anxiety disorder (χ2
2 = 6.12, P < .05). Group with overall TBI presented with significantly higher rates of any anxiety disorder (χ2
1 = 5.36, P = .02), panic attacks (χ2
1 = 4.43, P = .04), specific phobias (χ2
1 = 4.17, P = .04), and depression (χ2
1 = 3.98, P < .05). Prediction analysis revealed a statistically significant model (χ2
7 = 41.84, P < .001) explaining 23% to 37% of the variance in having any anxiety disorder, with significant predictors being group (TBI) and gender (female).

Conclusions:
Children who have sustained a TBI may be vulnerable to persistent anxiety, panic attacks, specific phobias, and depression, even 13 years after the injury event.