bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systemic Juvenile Idiopathic Arthritis and arthralgia - can it be diagnosed early within the window period? – An observation of serum biomarkers and analysis with other differential conditions in children
Authors: RAM SUDHAN S  , MuthuKumar Subramanian  , Rajkumar V  , Fardeen Shariff  , Linish Baalan R  , Sharat Balemane  
Published: September 2024

Background: Systemic juvenile idiopathic arthritis (sJIA)is a cause of persisting arthralgia which is often missed. Diagnosing sJIA can be challenging, especially when overt arthritis is absent at presentation, highlighting the need for a diagnostic biomarker. Few recent studies have assessed potential biomarkers for sJIA, however, there is no consensus in detecting early. We conducted a study evaluating serum IL-1, IL-6, IL-18, S100A8, and S100A9 as potential diagnostic markers to distinguish sJIA from other conditions presenting as joint pain in children.
Methods: A prospective study was conducted in our institute from May-2019 to October-2020 in children under 16 years, who had persisting arthralgia. Serum concentrations of IL-1, IL-6, IL-18, S100A9, and S100A8 were determined using ELISA kits. Receiver operating curve (ROC) analysis was used to determine the cut-off values for IL-1, IL-6, IL-18, S100A8, and S100A9 for differentiating sJIA from other causes of joint pain and fever.
Results- Out of 47 children who presented with joint pain and fever 19 of them were eventually diagnosed with sJIA. In the other 28 children, arthralgia and fever was attributed to conditions other than sJIA (non-sJIA). The non-sJIA group comprised children with acute lymphoblastic leukemia, hemophagocytic histiocytosis, systemic lupus erythematosus, Kawasaki disease, Kikuchi disease, and inflammatory bowel disease. Serum levels of IL-18, S100A8, and S100A9 were significantly higher in patients with sJIA compared to the non-sJIA group (p<0.05). The area under the curve (AUC) was significant for IL-18(77.9%), S100A8 (74.9%), and S100A9(71.2%). A serum IL-18 cut-off level of > 2030.45 pg/ml was useful for differentiating between sJIA and other diseases with a sensitivity of 66.67% and specificity of 75.86% for the diagnosis of sJIA.
Conclusion- Serum IL-18, S100A8, and S100A9 can be useful in differentiating sJIA early from other causes of persisting arthralgia in children provided with appropriate identification of symptomatology and suspicion.
Konsep Administrasi Pendidikan
Authors: Fathimah Meti , Hasanah Amalia , Azkiyah Azkiyah 
Published: September 2024

This paper explains the concept of educational administration which is a support for achieving educational goals effectively and efficiently. Administration in education that is orderly and organized is needed to improve the ability to manage education for principals and teachers. The purpose of this paper is to explain the meaning, urgency, purpose, function, process and scope of educational administration. The research method used in this research uses the library research method, namely research based on processed manuscripts (manuscript studies), facts and primary and secondary data (supporting data) related to the focus of the research. The results of this study indicate that educational administration is essentially a tool to achieve optimal educational goals. Because the school is a sub-system of the national education system. The educational administration process includes the functions of organizational planning, coordination, communication, supervision, financing supervision, and evaluation. All these functions are very closely related to each other.
El centro profundo de mi ombligo
Authors:   Atarraya
Published: September 2024

<strong>
Brenda R. Fernández
</strong>
, DR © Colección: Transponibilidad Mixed media on canvas. 120 x 100 cms De esta colección dice su autora: Una tarde, reflexionando sobre la conceptualización del amor, me di cuenta como de forma subconsciente hemos construido, como humanidad, la idea del Amor desde la violencia y el condicionamiento.
Sin título
Authors:   Atarraya
Published: September 2024

<strong>
Adriana Marenco Sánchez
</strong>
, DR © Fotografía digital Córdoba, Veracruz, s.a. Esta es una reproducción digital, con fines de divulgación, de una obra original proporcionada por su autor/a o propietario/a. Todos los derechos están reservados por el/la artista.
Retos en la formación del Grado en Farmacia ante la nueva Directiva europea 2024/782 de 4 de marzo de 2024
Authors: Gastelurrutia Miguel Ángel , Solinís María Ángeles , Calvo Begoña 
Published: September 2024

Recientemente se ha publicado la Directiva Delegada (UE) 2024/782 de la Comisión, de 4 de marzo de 2024, por la que se modifica la Directiva 2005/36/CE del Parlamento Europeo y del Consejo en lo relativo a los requisitos mínimos de formación para las profesiones de enfermero responsable de cuidados generales, odontólogo y farmacéutico.
Tal como se señala en el documento, su contenido es consecuencia del análisis de la evolución de la profesión en el que se constataron los grandes avances científicos y técnicos que, según la Comisión, no estaban representados, o no estaban suficientemente representados, en los requisitos mínimos de formación que establecía la Directiva 2005/36/CE actualmente vigente…
Implementasi Bimbingan Mengaji dengan Metode Yanbu’a sebagai Upaya Pembentukan Karakter Religiusitas pada Anak TPQ As-Sidiq Desa Talang Sebaris
Authors: Adrian Topano  , Indah Oktaviani  , Novita Kemala Dewi  , Shella Pironica  , Deva Surya Firdaus  , Robi Riyansyah  , Lidya Damayanti  
Published: September 2024

Religious education and character education are two related concepts. In its application, Al-Quran teaching plays a very important role in shaping children's character through guidance, continuous education and advice to instill religious, independent and communicative qualities in them from an early age. The aim of this research is to develop the implementation of religious character in higher education religious activities. The research methodology used is qualitative. With religious education that teaches the art of reading the Koran and its translations, the role of Taman Al-Coran (TPQ) is very important in forming the character of babies from an early age. Apart from that, there are other religious practices, such as memorizing short poetry and daily prayers, which can indirectly provide Islamic life lessons. However, a child's character must also be shaped and guided by his family so that he grows into a good person. The application of religious character in religious activities takes the form of participation in what are called "testimony and prayer activities" (Dhuha), direct direction of tahfidz, tilawati, and Friday blessing activities carried out in the context of santri activities. develop religious character. There is a positive correlation, meaning that there is a positive influence of religious activities on students' religious character. Religious activities are a useful means of developing and practicing religious character. Character development through positive habits will give birth to the habit of appreciating lessons, values, thoughts, ideology, or even doctrine, so that it becomes a belief and fosters a sense of self-awareness of reality or normative values ​​that appear in actions and attitudes. With the aim of being applicable to all schools in Indonesia, this research has implications for the growth of religious character in education.
Hacia una Loja sostenible: estrategias para la administración eficaz
Authors: Samaniego Luna Patricia Noemi 
Published: September 2024

Las ciudades sostenibles son fundamentales para lograr un desarrollo humano equilibrado y respetuoso con la naturaleza. Estas ciudades tienen la capacidad de garantizar plenamente los derechos fundamentales de sus residentes, permitiendo el acceso universal a vivienda digna, agua potable, saneamiento adecuado, seguridad alimentaria, servicios de educación y salud de calidad; de la misma manera una infraestructura resiliente que facilite una movilidad sostenible y preserve un ambiente sano. Por lo tanto, esta investigación tiene como como objetivo, desarrollar una revisión de la literatura académica sobre los elementos clave que definen una ciudad sostenible y las estrategias que permiten a las ciudades avanzar hacia la consolidación de un modelo de desarrollo urbano sustentable e integral, con un enfoque en la planificación inclusiva, sostenible y resiliente para la ciudad de Loja. A través de una metodología bibliográfica, se concluye que la implementación de políticas y estrategias que promovieron el uso adecuado de los recursos de origen natural y tecnológicos contribuyeron a la reducción de la contaminación y la degradación ambiental. No obstante, es relevante señalar que no existe un modelo único de ciudad sostenible ideal; cada ciudad define su propia visión del futuro y se apoya en un modelo de planificación inclusiva.
Designing Information Technology Governance in the Data Management Process Using Cobit Framework V 4.1 At the Pamulang University IT Center
Authors: Zein Afrizal 
Published: September 2024

This paper explores the implementation of Information Technology (IT) governance in the data management process using the Control Objectives for Information and Related Technologies (COBIT) framework version 4.1 at the IT Center of Pamulang University. The study begins by providing an overview of the COBIT framework and its relevance to IT governance in educational settings. It then delves into the specific application of COBIT V 4.1 in the context of data management processes at Pamulang University IT Center. This includes the identification of key control objectives and control practices within the COBIT framework that are applicable to data management, such as data governance, data quality management, data security, and data lifecycle management. Furthermore, the paper discusses the methodology used for implementing COBIT V 4.1 in the data management process, including the steps involved in assessing current practices, identifying areas for improvement, and designing governance structures and processes. It highlights the importance of collaboration between IT professionals, data stewards, and organizational leadership in ensuring the successful implementation of IT governance practices. The findings of the study reveal the benefits of adopting COBIT V 4.1 in the data management process at Pamulang University IT Center, including improved data quality, enhanced data security, and increased accountability and transparency in data handling practices.
EFFICACY OF SHRIMP SHELL SYNTHESIZED CHITOSAN AGAINSTPOST-HARVEST SPOILAGE FUNGI OF Sesamum indicum
Authors: IHUM TEMITOPE ADEPEU , Oledibe Chioma Francisca , Aremu Mariam Bukola , Yusuf Kayode Abel , Ige Mercy Itohan , Kurrah Inikpi Amazing grace , Tope Joyce Olatunji , Elizabeth Abiola Kayode 
Published: September 2024

Contamination of Agricultural commodities by moulds poses significant challenges due to conducive climatic conditions. Mycotoxins produced by moulds like Aspergillus, Penicillium, and Fusarium present health risks and economic losses. Traditional control measures such as the use of fungicides have drawbacks, necessitating the exploration of eco-friendly alternatives. One such alternatives is the use of Chitosan, a biopolymer derived from chitin found in crustacean exoskeletons. This study evaluated the efficacy of chitosan synthesized from shrimp shells in inhibiting the growth of Aspergillus niger, a common food borne mould of oil seeds such as Sesame. Synthesized Chitosan was characterized using FTIR spectroscopy, UV-visible spectroscopy, and the degree of deacetylation was determined. FTIR analysis showed characteristic absorption peaks ranging from 3911.77 cm-1 to 794.70 cm-1, with higher wave numbers corresponding to stretching vibrations of the C-H, O-H, and N-H bonds functional groups. UV-visible spectroscopy displayed an absorbance peak at 232 nm with an absorbance value of 2.15. The degree of deacetylation of synthesized chitosan was determined to be 98.99%. In vitro experiments showed a concentration-dependent inhibition of A. niger growth by shrimp shell synthesized chitosan. The highest level of inhibition was seen at day 3 with 0.75mg/ml (50%) and 1.0mg/ml (52.1%), meaning the higher the concentration of shrimp shell synthesized chitosan the higher the inhibition. Results suggest chitosan as a potential anti-fungal agent for food preservation and agricultural protection against mould contamination and mitigate post harvest losses and ensure food safety.
QАDRIYАTLАR SОHАSI VА АKSIОLОGIYА QОNUNLАRI TRАNSFОRMАTSIYАSINING IJTIMОIY TАRАQQIYОTGА BОG‘LIQLIGI
Authors: To‘xtayev Hakim 
Published: September 2024

The article reveals the content of the development of values in society and the improvement of their transformation, as well as the role of social and axiological factors that are specific to a particular place in the process of developing our national values.
Evolution and Innovation of Guangxi Yao Mountain Residential Architecture Space from the Perspective of Cultural Heritage
Authors: Ying Xu  , Pisit Puntien  , Akapong Inkuer  , Chanoknart Mayusoh  
Published: September 2024

Enhancing national cultural self-confidence involves promoting and strengthening the protection and utilisation of traditional national villages. Studying how to protect and inherit the resources of these villages, as well as utilising existing resources in a sustainable manner, poses a challenging issue. Further research is needed to investigate the influence of regional culture on residential buildings in the mountainous areas of the Yao people in Guangxi, and to explore how traditional architectural elements can preserve their cultural essence using modern artistic language. The project aims to: 1. Examine how regional culture influences Yao ethnic minority houses in Guangxi's mountains; 2. Evaluate existing challenges and implement contemporary design for improvement; 3. Create sustainable and culturally significant Yao mountain dwellings. The research collected qualitative data from six towns using a combination of semi-structured interviews, participant observation, and reviewing internet and print news sources. The residential structures in Yaochi Mountain District, Guangxi exhibit unique regional cultural traits, although they also have deficiencies in several areas. This study find that the beauty of the natural environment remains constant but the architectural vestiges and cultural history show remarkable variance, both of which greatly contribute to sustainable development. This study found that traditional villages in Guangxi share a number of characteristics, including a severe deficiency in clean energy and a poor rate of carbon utilisation, during our investigation of the sustainable development of the spatial dimension of the ecological legacy of these communities. According to a weight analysis performed at the sub-index factor level, the variety of building uses is the most important indicator of the spatial sustainability of traditional villages in Guangxi. The outcomes of this study provided a valuable empirical evidence and practical suggestions for areas and nations involved in the preservation of cultural heritage and the investigation of sustainable rural development.
Virtual Screening of Novel Non-Lactam Inhibitors Against CTX-M-15 β-Lactamase for Enhancement and Remodeling of Antibiotic Efficiency
Authors: Aaroj  , Siddiqui Mahrukh , Rehman Arsheen , Hurera Abu , Ahmad Rehan , Muhammad Islam Saad 
Published: September 2024

Background & Objective: The CTX-M-15 are beta-lactamases that break down practically all the antibiotics that belong to the beta-lactam group resulting in antibiotic resistance in bacteria. Several beta-lactam inhibitors can be used in combination with different cephalosporin antibiotics to treat infections caused by microbes that produce the CTX-M-15 enzyme. This study aims to use a multi-step virtual screening strategy to screen three new non—lactam inhibitors against CTX-M-15.
Methods: A study was designed and conducted in the Department of Biotechnology at the University of Central Punjab. A multi-step virtual screening strategy was used to screen three new non—lactam inhibitors against CTX-M-15. The CTX-M-15 binding sites were explored to determine the possible target sites of the inhibitors. Compounds from the E-LEA3D were subjected to virtual screening, and their performance was evaluated based on the binding energies and various other factors. Using Auto Dock Vina, the docking complexes were formed and visualized in Pymol where their RMSD values and binding energies were compared.
Results: The best results were found in the case of Isoproterenol as it inhibited the lactamase activity of CTX-M 15 by forming a stable docked complex. The molecular docking simulations using Autodock Vina revealed favorable binding interactions, indicating the ability of Isoproterenol to bind to the active site.
Conclusion: The lactamase activity of CTX-M 15 was inhibited by Isoproterenol as they form a stable docked complex. Designing inhibitors against the CTX-M-15 type β-lactamase represents a promising avenue for combating drug-resistant bacteria.
Pendampingan Pengabdian Masyarakat Program Penghijauan di Kelurahan Koang Jaya Kota Tangerang, Provinsi Banten
Authors: Christiani Susan 
Published: September 2024

Kelurahan Koang Jaya memiliki kampung tematik dengan konsep kampung wisata BAMBU (belajar dan berkebun) dua tempat yang mewakili tempat tersebut adalah Kampung Inggris sebagai pusat belajar dan Kampung Paniis sebagai pusat berkebun.

Kata kunci :Pendampingan pengabdian masyarakat, program penghijauan
BERBAGI TAKJIL DI BULAN RAMADHAN BERSAMA SIVITAS AKADEMIKA DALAM KEBERSAMAAN DAN KERAGAMAN
Authors: Sutrisno Gono , Swastika Gusti Krisna Dewi Puri , Bramantyo Andreas , Amelia Dahlia 
Published: September 2024

Tujuan dengan diadakannya kegiatan berbagi Tajil bersama Sivitas akademika Universitas Utpadaka Swastika di bulan Ramadhan,diharapakan dapat memperkuat hubungan kebersamaan,menguatkan nilai-nilai persauadaraan antara Mahasiswa ,Dosen,Tenaga kependidikan dan Yayasan.Diharapkan juga mahasiswa dapat memiliki rasa kerperdulian dan tanggung jawab,juga meningkatkan semangat keagamaan mahasiswa dan semangat toleransi Kegiatan pembagian Tajil bersama merupakan upaya untuk mempererat hubungan antar anggota komunitas akademik selama bulan Ramadhan. Kegiatan pengabdian masyarakat dalam bentuk berbagi Tajil ini adalah untuk meningkatkan kebersamaan, menghormati keanekaragaman, menghidupkan nilai-nilai kemanusiaan, membangun persaudaraan, memberikan kenyamanan bagi yang berpuasa, dan mengenalkan budaya Ramadhan. Metode yang digunakan mencakup perencanaan, promosi, persiapan makanan, dan pelaksanaan kegiatan yang dilaksanan dari tanggal 13 Maret samapi 3 April 2024 dengan tempat pelaksanaan kegiatan di Kampus Universitas Utpadaka Swastika.Hasilnya mencakup partisipasi yang luas, peningkatan kebersamaan, penghargaan terhadap keanekaragaman, pemahaman yang lebih baik tentang nilai-nilai kemanusiaan, pembentukan hubungan persaudaraan yang kuat, dukungan bagi yang berpuasa, dan peningkatan kesadaran tentang budaya Ramadhan. Melalui kegiatan ini, Sivitas Akademika Universitas Utpadaka swastika dapat memperkaya kehidupan sosial mereka, memperkuat ikatan persaudaraan, dan mempromosikan nilai-nilai inklusivitas dan kepedulian sosial di antara anggotanya.
ANALISIS DESAIN LOGO UNIVERSITAS UTPADAKA SWASTIKA (UTPAS) : KAJIAN SEMIOTIKA
Authors: Dian Sari Nani 
Published: September 2024

Logo UTPAS (Universitas Utpadaka Swastika) menghadirkan beberapa bentuk atau objek, seperti kelopak bunga, tumbuhan padi, kapas, mercusuar, pita serta di dominasi dengan warna kuning dan ungu yang tentunya mewakili identitas UTPAS. Peneliti tertarik mengkaji logo UTPAS karena ingin mengetahui makna yang terdapat pada logo UTPAS dan sekaligus mampu menjadi media informasi bagi masyarakat terhadap UTPAS. Penelitian ini menggunakan metode kualitatif, serta dianalisis dengan menggunakan pendekatan semiotika Charlesh Sanders Pierce. Berdasarkan hasil analisis bahwa logo UTPAS dimaknai berdasarkan jenis dan representamen yaitu menggambarkan sebuah Lembaga Pendidikan Tinggi yang memiliki tujuan sebagai pedoman hidup setiap insan yang berada di dalam lingkupnya melalui ilmu pengetahuaan, sikap toleransi, dan penyertaan Tuhan Yang Maha Esa. Hal tersebut direpresentasikan dengan objek bentuk buku, mercusuar dan api yang menimbulkan kesan cahaya. Selain itu pada desain logo juga menjelaskan histories lahirnya nama UTPADAKA SWASTIKA yang di representasikan dengan objek padi berjumlah tiga puluh dan kapas berjumlah enam yang di interpretasikan sebagai tanggal dan bulan lahirnya nama UTPAS. Selanjutnya berdasarkan relasi tanda dengan objeknya, logo UTPAS menggunakan representasi objek yang telah disepakati secara umum, sehingga setiap penikmat melihat visual representasi objek dalam logo mengeluarkan pernyataan (Sinsign) dengan arti yang telah disepakati secara Legisign sesuai pengalaman penikmat, serta terdapat kombinasi warna ungu menyimbolkan kreativitas dan kebijaksanaan dan warna kuning menyimbolkan kebahagiaan. Posisi bawah pada bagian logo UTPAS terdapat teks yang bertuliskan “Universitas Utpadaka Swastika” yang melambangkan hasil akhir dan landasan dari proses yang ada sebelumnya yaitu menciptakan kejayaan dengan tetap menjaga persatuan dan persaudaraan. Berdasarkan keseluruhan, logo UTPAS telah memenuhi kaidah-kaidah dalam penciptaan sebuah design grafis, kaidah tersebut bisa dilihat salah satunya yaitu kesesuaian makna logo terhadap entitas.
INNOVATION MANAGEMENT TO CREATE A GROWING COMPANY BY USING A MEMBER CARD AT NATASHA MILK SHOP
Authors: Toto.Hermanto Toto.Hermanto 
Published: September 2024

ABSTRACT
Every year the development of technology is getting faster and every year many companies develop technology from small companies to bona fide companies. Natasha's milk shop is a company that has only started pioneering since 2010 so there are many problems starting with the absence of member cards for consumers, member cards aim to provide promos, discounts and points for every product sales transaction to consumers who shop and with the member card, both parties are mutually beneficial between consumers and companies, member cards also function as branding media, branding media when consumers feel many benefits from using member cards, consumers want to shop and use member cards again. Natasha milk shop companies do not apply member cards If the member card does not exist this is a very serious problem and must be addressed immediately by the natasha milk shop company, the development of technology that cannot be utilized properly by the natasha milk shop company so that there are problems that must be overcome. So with this peniliti want to discuss, innovate and find solutions for the progress of the company natasha milk shop, the purpose of this study wants to make an innovation in the development of technology by making application-based applications so that readers understand the procedures for use from starting member card registration to using member cards in the application. After the application has been developed, the company gives questions to consumers, these questions are to provide the extent of the System Usability Scale for the company. After the System Usability Scale is carried out the results of 15 respondents form 1315: 15 = 88 then for the total calculation of 88, (70 - 90 Good Exellent).