bluuebunny/crossref_metadata_2025_split huggingface dataset:
СУЧАСНІ АСПЕКТИ ДІАГНОСТИКИ ПАТОЛОГІЧНИХ ПРОЦЕСІВ ШИЙКИ МАТКИ В ЖІНОК ІЗ ЕНДОКРИННИМ НЕПЛІДДЯМ
Authors: Boichuk A. V. , Shadrina V. S. , Sopel V. V. , Khudobiak V. O. 
Published: October 2017

Мета дослідження – вивчити особливості гормональних змін в організмі жінки при патологічних процесах шийки матки.Матеріали та методи. Під час обстеження використовували клінічні, біохімічні, гістологічні, апаратно-інструментальні методи обстеження. Зокрема вивчали анамнестичні дані, результати CVU, цитології, Пап-тесту, даних розширеної кольпоскопії, гістологічного обстеження, УЗД, базальної температури, результатів обстеження на ІПСШ і ВПЛ методом ПЛР, гормонального обстеження.Результати дослідження та їх обговорення. За період з 2011 по 2015 рік під спостереженням перебували 105 жінок віком від 18 до 42 років, середній вік яких становив (25,92±0,61) року. Критеріями для включення пацієнток у дослідження були патологічні процеси шийки матки і порушення менструального циклу. Пацієнток було поділено на 2 групи, по 40 жінок у кожній. Першу групу становили жінки із фоновими процесами шийки матки (ектопії, ектропіони, цервіцити), другу групу – жінки із передраковими захворюваннями шийки матки (дисплазії, лейкоплакії). До групи контролю входили 25 гінекологічно здорових невагітних жінок віком від 18 до 38 років, середній вік яких становив (21,44±0,38) року. При аналізі рівнів гормональних показників у жінок із ендокринними порушеннями і патологічними процесами шийки матки було встановлено вплив гіперандрогенії і недостатності лютеїнової фази на перебіг проліферативних процесів шийки матки. Виявлено, що у таких жінок спостерігається високий відсоток гіперандрогенії (у 46,25 %) та недостатності лютеїнової фази (у 32,5 %), рідше – гіперестрогенемія (у 11,25 %).Висновки. Встановлено, що серед етіологічних факторів розвитку захворювань шийки матки провідне місце належить вірусним асоціаціям, видовий спектр яких складають переважно асоціації родини герпесвірусів (цитомегаловірус – 43,75 %, вірус простого герпесу ½ типу – 41,25 %, вірус Епштейна–Барр – 27,5 %), а також вірус папіломи людини – 40,0 % та інфекції, що передаються статевим шляхом (Ureaplasma spp. – 62,5 %, Chlamydia trachomаtis – 11,25 %, Mycoplasma genitalium – 3,75 %).
Outcomes of Primary and Secondary Carotid Artery Stenting
Authors: Arhuidese Isibor J. , Rizwan Muhammad , Nejim Besma , Malas Mahmoud 
Published: October 2017

Background and Purpose—
Little is known of the excess risk attributable to secondary carotid angioplasty and stenting (CAS). This study evaluates outcomes of redo-CAS and CAS after prior ipsilateral carotid endarterectomy (CASAPICEA) relative to primary-CAS.

Methods—
We studied all patients in the Vascular Quality Initiative, who underwent primary-CAS, CASAPICEA, or redo-CAS (2003–2016). Kaplan–Meier, multivariable logistic and Cox regression analyses were used to evaluate outcomes within 30 days and up to 1 year and identify their predictors.

Results—

There were 11 742 CAS procedures performed: 8519 (72%) primary-, 2645 (23%) CASAPICEA, and 578 (5%) redo-CAS. Comparing primary-CAS versus CASAPICEA versus redo-CAS, 30-day stroke/death was 2.5% versus 2.0% versus 1.3% for asymptomatic patients (
P
=0.23) and 5.2% versus 2.6% versus 5.0% for symptomatic patients (
P
=0.003). CASAPICEA was associated with significantly lower 30-day stroke/death (odds ratio: 0.60; 95% confidence interval: 0.37–0.98;
P
=0.04) compared with primary-CAS among symptomatic patients. The odds of bradycardia were lower following CASAPICEA (odds ratio: 0.32; 95% confidence interval: 0.26–0.39;
P
<0.001) and redo-CAS (odds ratio: 0.55; 95% confidence interval: 0.39–0.78;
P
=0.001) compared with primary-CAS. Similarly, the odds of hypotension were significantly lower in both groups compared with primary-CAS (CASAPICEA: 0.41 [0.35–0.48],
P
<0.001; redo-CAS: 0.66 [0.50–0.86]
P
=0.003). There were no significant differences in the hazards of stroke/death at 1 year for CASAPICEA and redo-CAS compared with primary-CAS.

Conclusions—
CASAPICEA is associated with significantly lower odds of periprocedural stroke/death compared with primary-CAS among symptomatic patients. CASAPICEA and redo-CAS are associated with significantly lower odds of periprocedural hypotension and bradycardia but higher odds of hypertension compared with primary-CAS.
Predictors of Outcome in Aneurysmal Subarachnoid Hemorrhage Patients
Authors: Galea James P. , Dulhanty Louise , Patel Hiren C. 
Published: October 2017

Background and Purpose—
The mortality and morbidity after aneurysmal subarachnoid hemorrhage has improved because of better diagnosis, early treatment to secure the aneurysm, and better management of disease-specific complications. With these improvements in care, it is not clear if the previously identified independent predictors of a negative outcome have changed. The aim of this study was to identify the independent predictors of an unfavorable outcome (Glasgow Outcome Score 1, 2, and 3) in aneurysmal subarachnoid hemorrhage patients.

Methods—
Univariate and multivariate analysis of prospectively collected data on patients presenting with an aneurysmal subarachnoid hemorrhage was performed. Outcome was assessed at discharge. Data were collected from 14 centers in the United Kingdom over a period of 4 years (September 2011–2015).

Results—

The median age (interquartile range) at presentation of 3341 patients with aneurysmal subarachnoid hemorrhage was 55 (18) years. Most patients were female (n=2288 [68.5%]), presented in good grade (2397 [70%]; World Federation of Neurological Surgeons grade 1 and 2), and were treated by endovascular coiling (n=2600; 75%). The independent predictors of an unfavorable outcome (95% confidence interval [CI]) were increasing age (odds ratio [OR], 1.04; 95% CI, 1.03–1.05;
P
<0.001), World Federation of Neurological Surgeons grade (OR, 2.06; 95% CI, 1.91–2.22;
P
<0.001), preoperative rebleeding (OR, 7.41; 95% CI, 4.48–12.30;
P
<0.001), need for cerebrospinal fluid diversion (OR, 3.25; 95% CI, 2.58–4.09;
P
<0.001), and delayed cerebral ischemia (OR, 2.21; 95% CI, 1.72–2.83;
P
<0.001).

Conclusions—
These data suggest that potentially modifiable risk factors of preoperative rebleeding and delayed cerebral ischemia are associated with unfavorable outcomes. Understanding the reasons why patients requiring cerebrospinal fluid diversion have 3.25-fold higher adjusted odds of a poor outcome at discharge needs to be studied.
One-Year Outcomes After Minor Stroke or High-Risk Transient Ischemic Attack
Authors: Park Hong-Kyun , Kim Beom Joon , Han Moon-Ku , Park Jong-Moo , Kang Kyusik , Lee Soo Joo , Kim Jae Guk , Cha Jae-Kwan , Kim Dae-Hyun , Nah Hyun-Wook , Park Tai Hwan , Park Sang-Soon , Lee Kyung Bok , Lee Jun , Hong Keun-Sik , Cho Yong-Jin , Lee Byung-Chul , Yu Kyung-Ho , Oh Mi-Sun , Kim Joon-Tae , Choi Kang-Ho , Kim Dong-Eog , Ryu Wi-Sun , Choi Jay Chol , Johansson Saga , Lee Su Jin , Lee Won Hee , Lee Ji Sung , Lee Juneyoung , Bae Hee-Joon 
Published: October 2017

Background and Purpose—
Patients with minor ischemic stroke or transient ischemic attack are at high risk of recurrent stroke and vascular events, which are potentially disabling or fatal. This study aimed to evaluate contemporary subsequent vascular event risk after minor ischemic stroke or transient ischemic attack in Korea.

Methods—
Patients with minor ischemic stroke or high-risk transient ischemic attack admitted within 7 days of symptom onset were identified from a Korean multicenter stroke registry database. We estimated 3-month and 1-year event rates of the primary outcome (composite of stroke recurrence, myocardial infarction, or all-cause death), stroke recurrence, a major vascular event (composite of stroke recurrence, myocardial infarction, or vascular death), and all-cause death and explored differences in clinical characteristics and event rates according to antithrombotic strategies at discharge.

Results—
Of 9506 patients enrolled in this study, 93.8% underwent angiographic assessment and 72.7% underwent cardiac evaluations; 25.1% had symptomatic stenosis or occlusion of intracranial arteries. At discharge, 95.2% of patients received antithrombotics (antiplatelet polytherapy, 37.1%; anticoagulation, 15.3%) and 86.2% received statins. The 3-month cumulative event rate was 5.9% for the primary outcome, 4.3% for stroke recurrence, 4.6% for a major vascular event, and 2.0% for all-cause death. Corresponding values at 1 year were 9.3%, 6.1%, 6.7%, and 4.1%, respectively. Patients receiving nonaspirin antithrombotic strategies or no antithrombotic agent had higher baseline risk profiles and at least 1.5× higher event rates for clinical event outcomes than those with aspirin monotherapy.

Conclusions—
Contemporary secondary stroke prevention strategies based on thorough diagnostic evaluation may contribute to the low subsequent vascular event rates observed in real-world clinical practice in Korea.
After Marx, the Deluge
Authors: Blumenfeld Jacob 
Published: October 2017

Abstract
‘After Marx’ or ‘According to Marx’. Thus translates the intentionally ambiguous title of ‘Nach Marx’, an international collection of twenty diverse essays in German on Marx and social philosophy today. ‘Nach Marx’ contains over five hundred pages of contributions from twelve prominent German philosophers and sociologists (Hauke Brunkhorst, Alex Demirović, Rainer Forst, Axel Honneth, Rahel Jaeggi, Daniel Loick, Andrea Maihofer, Oliver Marchart, Christoph Menke, Hartmut Rosa, Michael Quante, Titus Stahl), six American political philosophers, German idealists, and historians (Wendy Brown, Daniel Brudney, Raymond Geuss, Frederick Neuhouser, Terry Pinkard, Moishe Postone), along with a British Hegelian philosopher (Andrew Chitty) and a French political thinker (Étienne Balibar). Although the book is divided into six themed parts (I. Freedom and Community, II. Normativity and Critique, III. Truth and Ideology, IV. Right and Subjectivity, V. Critique of Capitalism and Class Struggle, VI. Political Praxis), the essays are mostly individual excurses in Marx scholarship.
Thinking Through Balibar’s Dialectics of Emancipation
Authors: Bromberg Svenja 
Published: October 2017

AbstractIn this review, I discuss Balibar’s ‘proposition of equaliberty’ with regard to its theoretical status and contribution, its relationship to other contemporary theories of radical democracy as well as to the problematic of bourgeois versus communist emancipation in Marx. The primary interest of this essay is to develop a detailed understanding of Balibar’s analytical schema, which draws a complex picture of our contemporary ‘human condition’, and to place it within his own theoretical development since his contribution toReading Capitalin the 60s. On that basis, it will be possible to assess his contribution to thinking politics with and after Marx and place it more concretely within the generalised radical-democratic turn in post-Marxist theory.
The European Cooperation in the Southern Mediterranean: The Multilateralization of Bilateral Relations?
Authors: Bicchi Federica 
Published: October 2017

Summary
This article focuses on institutionalized forms of diplomatic cooperation among European Union (eu) members in southern Mediterranean capitals. It argues that European diplomatic cooperation represents a thin form of multilateralization of member states’ bilateral relations with southern Mediterranean countries. By analysing diplomatic presence on the ground, it shows that the European Union delegations in the area are not only big, but also politically strong, and they interact with a large number of national diplomats. The article examines how eu delegations in the southern Mediterranean represent a diplomatic ‘site’, in which diplomacy occurs in the shape of information-gathering, representation and negotiation, including among eu member states. This does not amount to a single European diplomatic system, however, as coordination remains thin to date and the agenda-setting mechanisms for eu delegations’ work and for European diplomatic cooperation have not (yet?) been fully developed.
Multicenter Validation of Enhancer of Zeste Homolog 2 Expression as an Independent Prognostic Marker in Localized Clear Cell Renal Cell Carcinoma
Authors: Ho Thai Huu , Kapur Payal , Eckel-Passow Jeanette E. , Christie Alana , Joseph Richard W. , Serie Daniel J. , Cheville John C. , Thompson R. Houston , Homayoun Farrah , Panwar Vandana , Brugarolas James , Parker Alexander S. 
Published: October 2017

Purpose Enhancer of zeste homolog 2 (EZH2), a chromatin remodeler, is implicated in the pathogenesis of clear cell renal cell carcinoma (ccRCC). However, the effect of EZH2 on outcomes in localized ccRCC is unclear, and molecular biomarkers are not currently integrated into prognostic models or adjuvant therapy trials. Methods We performed Cox regression to evaluate the association of tumor-based EZH2 gene and protein expression with survival in three independent cohorts: a cohort from The Cancer Genome Atlas (n = 532), a cohort from University of Texas Southwestern Medical Center (n = 122), and a cohort from Mayo Clinic (n = 1,338). Analyses were adjusted for the prognostic stage, size, grade, and necrosis (SSIGN) score as well as within low-, intermediate-, and high-risk SSIGN groups. Results Patients in The Cancer Genome Atlas cohort with EZH2-high gene expression were 1.5 times more likely to experience overall death than patients with EZH2-low expression (95% CI, 1.1 to 2.3; P = .028). Patients in the University of Texas Southwestern Medical Center cohort with EZH2-high protein expression were two times more likely to experience overall death than patients with EZH2-low expression (95% CI, 1.1 to 4.4; P = .034). Similarly, patients in the Mayo Clinic cohort with EZH2-high protein expression were 1.4 times more likely to experience overall death (95% CI, 1.2 to 1.7; P < .001). Patients in the Mayo Clinic cohort with EZH2-high protein expression were nearly two times more likely to experience RCC-specific death (95% CI, 1.5 to 2.6; P < .001); EZH2 protein expression was particularly prognostic among patients with low-risk SSIGN tumors (HR, 6.1; 95% CI, 3.4 to 11.1; P < .001). Conclusion EZH2 expression accurately predicts risk of RCC death beyond existing clinicopathologic models, particularly in low- and intermediate-risk SSIGN tumors. Further studies are required to incorporate molecular biomarkers into surveillance guidelines and adjuvant clinical trials.
Association Between Precautionary Behaviors and Breast Cancer–Related Lymphedema in Patients Undergoing Bilateral Surgery
Authors: Asdourian Maria S. , Swaroop Meyha N. , Sayegh Hoda E. , Brunelle Cheryl L. , Mina Amir I. , Zheng Hui , Skolny Melissa N. , Taghian Alphonse G. 
Published: October 2017

Purpose This study examined the lifestyle and clinical risk factors for lymphedema in a cohort of patients who underwent bilateral breast cancer surgery. Patients and Methods Between 2013 and 2016, 327 patients who underwent bilateral breast cancer surgery were prospectively screened for arm lymphedema as quantified by the weight-adjusted volume change (WAC) formula. Arm perometry and subjective data were collected preoperatively and at regular intervals postoperatively. At the time of each measurement, patients completed a risk assessment survey that reported the number of blood draws, injections, blood pressure readings, trauma to the at-risk arm, and number of flights since the previous measurement. Generalized estimating equations were applied to ascertain the association among arm volume changes, clinical factors, and risk exposures. Results The cohort comprised 327 patients and 654 at-risk arms, with a median postoperative follow-up that ranged from 6.1 to 68.2 months. Of the 654 arms, 83 developed lymphedema, defined as a WAC ≥ 10% relative to baseline. On multivariable analysis, none of the lifestyle risk factors examined through the risk assessment survey were significantly associated with increased WAC. Multivariable analysis demonstrated that having a body mass index ≥ 25 kg/m2 at the time of breast cancer diagnosis ( P = .0404), having undergone axillary lymph node dissection ( P = .0464), and receipt of adjuvant chemotherapy ( P = .0161) were significantly associated with increased arm volume. Conclusion Blood pressure readings, blood draws, injections, and number or duration of flights were not significantly associated with increases in arm volume in this cohort. These findings may help to guide patient education about lymphedema risk reduction strategies for those who undergo bilateral breast cancer surgery.
Adjuvant Chemoradiotherapy With Epirubicin, Cisplatin, and Fluorouracil Compared With Adjuvant Chemoradiotherapy With Fluorouracil and Leucovorin After Curative Resection of Gastric Cancer: Results From CALGB 80101 (Alliance)
Authors: Fuchs Charles S. , Niedzwiecki Donna , Mamon Harvey J. , Tepper Joel E. , Ye Xing , Swanson Richard S. , Enzinger Peter C. , Haller Daniel G. , Dragovich Tomislav , Alberts Steven R. , Bjarnason Georg A. , Willett Christopher G. , Gunderson Leonard L. , Goldberg Richard M. , Venook Alan P. , Ilson David , O’Reilly Eileen , Ciombor Kristen , Berg David J. , Meyerhardt Jeffrey , Mayer Robert J. 
Published: October 2017

Purpose After curative resection of gastric or gastroesophageal junction adenocarcinoma, Intergroup Trial 0116 (Phase III trial of postoperative adjuvant radiochemotherapy for high risk gastric and gastroesophageal junction adenocarcinoma: Demonstrated superior survival for patients who received postoperative chemoradiotherapy with bolus fluorouracil (FU) and leucovorin (LV) compared with surgery alone. CALGB 80101 (Alliance; Phase III Intergroup Trial of Adjuvant Chemoradiation After Resection of Gastric or Gastroesophageal Adenocarcinoma) assessed whether a postoperative chemoradiotherapy regimen that replaced FU plus LV with a potentially more active systemic therapy could further improve overall survival. Patients and Methods Between April 2002 and May 2009, 546 patients who had undergone a curative resection of stage IB through IV (M0) gastric or gastroesophageal junction adenocarcinoma were randomly assigned to receive either postoperative FU plus LV before and after combined FU and radiotherapy (FU plus LV arm) or postoperative epirubicin, cisplatin, and infusional FU (ECF) before and after combined FU and radiotherapy (ECF arm). Results With a median follow-up duration of 6.5 years, 5-year overall survival rates were 44% in the FU plus LV arm and 44% in the ECF arm ( Plogrank = .69; multivariable hazard ratio, 0.98; 95% CI, 0.78 to 1.24 comparing ECF with FU plus LV). Five-year disease-free survival rates were 39% in the FU plus LV arm and 37% in the ECF arm ( Plogrank = .94; multivariable hazard ratio, 0.96; 95% CI, 0.77 to 1.20). In post hoc analyses, the effect of treatment seemed to be similar across all examined patient subgroups. Conclusion After a curative resection of gastric or gastroesophageal junction adenocarcinoma, postoperative chemoradiotherapy using a multiagent regimen of ECF before and after radiotherapy does not improve survival compared with standard FU and LV before and after radiotherapy.
Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study
Authors: Wang Xuexia , Sun Can-Lan , Hageman Lindsey , Smith Kandice , Singh Purnima , Desai Sunil , Hawkins Douglas S. , Hudson Melissa M. , Mascarenhas Leo , Neglia Joseph P. , Oeffinger Kevin C. , Ritchey A. Kim , Robison Leslie L. , Villaluna Doojduen , Landier Wendy , Bhatia Smita 
Published: October 2017

Purpose Survivors of childhood cancer treated with cranial radiation therapy are at risk for subsequent CNS tumors. However, significant interindividual variability in risk suggests a role for genetic susceptibility and provides an opportunity to identify survivors of childhood cancer at increased risk for these tumors. Methods We curated candidate genetic variants from previously published studies in adult-onset primary CNS tumors and replicated these in survivors of childhood cancer with and without subsequent CNS tumors (82 participants and 228 matched controls). We developed prediction models to identify survivors at high or low risk for subsequent CNS tumors and validated these models in an independent matched case-control sample (25 participants and 54 controls). Results We demonstrated an association between six previously published single nucleotide polymorphisms (rs15869 [ BRCA2], rs1805389 [ LIG4], rs8079544 [ TP53], rs25489 [ XRCC1], rs1673041 [ POLD1], and rs11615 [ ERCC1]) and subsequent CNS tumors in survivors of childhood cancer. Including genetic variants in a Final Model containing age at primary cancer, sex, and cranial radiation therapy dose yielded an area under the curve of 0.81 (95% CI, 0.76 to 0.86), which was superior ( P = .002) to the Clinical Model (area under the curve, 0.73; 95% CI, 0.66 to 0.80). The prediction model was successfully validated. The sensitivity and specificity of predicting survivors of childhood cancer at highest or lowest risk of subsequent CNS tumors was 87.5% and 83.5%, respectively. Conclusion It is possible to identify survivors of childhood cancer at high or low risk for subsequent CNS tumors on the basis of genetic and clinical information. This information can be used to inform surveillance for early detection of subsequent CNS tumors.
Introduction: 2016 Daniel H. Wagner Prize for Excellence in Operations Research Practice
Authors: Butler C. Allen , Robinson Randall S. 
Published: October 2017

Competition for the 2016 Daniel H. Wagner Prize for Excellence in Operations Research Practice provided the six finalist papers featured in this special issue of Interfaces. The prestigious Wagner Prize—awarded for achievement in implemented operations research, management science, and advanced analytics—emphasizes quality and originality of mathematical models and clarity of written and oral exposition. Researchers from the Université Laval, The Forestry Research Institute of Sweden, and the SDC, Sweden, won the competition for their development of a highly successful algorithm and software to determine optimal routing for trucks operating in the Swedish forestry industry. The remaining finalist papers describe work to improve hospital staffing, dealer inventory of automotive vehicles, agricultural productivity through genetic modifications of crops, wastewater treatment, and real-time video ad selection. Full presentation videos with slides are available in the INFORMS Video Library at https://www.informs.org/Resource-Center/Video-Library , and as electronic companions to the Interfaces articles.