bluuebunny/crossref_metadata_2025_split huggingface dataset:
FUMA: Functional mapping and annotation of genetic associations
Authors: Watanabe Kyoko , Taskesen Erdogan , Arjen van Bochoven , Arjen van Bochoven , Posthuma Danielle 
Published: February 2017

ABSTRACTA main challenge in genome-wide association studies (GWAS) is to prioritize genetic variants and identify potential causal mechanisms of human diseases. Although multiple bioinformatics resources are available for functional annotation and prioritization, a standard, integrative approach is lacking. We developed FUMA: a web-based platform to facilitate functional annotation of GWAS results, prioritization of genes and interactive visualization of annotated results by incorporating information from multiple state-of-the-art biological databases.
An analysis of barriers for plastic recycling in the Indian plastic industry
Authors: Satapathy Suchismita 
Published: February 2017

Purpose
The purpose of this paper is to develop a new model in which the interrelationship between the barriers can be determined that hinder the implementation of effective recycling processes in the plastic sectors of India.

Design/methodology/approach
Today manufacturers do not want their input to be deemed waste and subsequently be discarded, so their efforts and resources have been channeled into the development of efficient recycling methods. However, there are several barriers hindering the implementation of effective and efficient recycling. In this paper several of the most influential barriers are taken into consideration and implemented in the interpretive structural modeling.

Findings
The results divided the barriers into four clusters and identified the weak and strong barriers and implemented relationships between them.

Research limitations/implications
Globally plastic waste has been steadily increasing. Recycling plastic has received much attention because many companies are using it as a strategic tool to serve their customers and to generate good revenue, but there is a lack of effective recycling units in India. The work of this paper and its results will be helpful in the implementation of an effective and efficient recycling unit for the plastic sector.

Practical implications
The recycling process can be improved by avoiding barriers of PLASTIC recycling.

Originality/value
In this paper, the plastic industries of India are studied and analyzed, and the barriers are found.
Motivation and training initiation: evidence from Poland
Authors: Mielniczuk Emilia , Laguna Mariola 
Published: February 2017

PurposeBased on the self-determination theory and the model of action phases, the present study aims to provide insight into motivational factors that are important for training initiation. It investigates the relations between three types of motivation (intrinsic, extrinsic and amotivation) and training initiation: intention to initiate new training and plan formulation.Design/methodology/approachData were collected from 155 employees using the Motivation for Training Initiation Scale and the Training Intention and Training Planning Scales.FindingsThe results of hierarchical regression analyses show that intrinsic and extrinsic motivation are positively, while amotivation is negatively, related to intention to start new training. Intrinsic motivation is a significant predictor of training plan formulation. The stronger is the intention, the more precise are plans to undertake training.Research limitations/implicationsThe cross-sectional study design limits causal conclusions concerning actual training action. This, therefore, encourages the validation of study hypotheses in a longitudinal manner.Practical implicationsThe results offer suggestions on how to foster training initiation taking into account types of motivation.Originality/valueThe study for the first time combines the model of action phases with the self-determination theory.
Delivering a shared library management system for Wales
Authors: Owen Gareth Wyn 
Published: February 2017

Purpose
A case study of the Wales Higher Education Libraries Forum (WHELF) project to procure and implement a shared library management system (LMS) for all universities in Wales, together with the National Health Service Libraries in Wales and the National Library of Wales. In particular, the purpose of this paper is to explore the drivers to this collaboration, outline the benefits achieved and the framework to realise further benefits.

Design/methodology/approach
Case study review of the process, together with a review of literature on consortia and LMSs.

Findings
WHELF has developed into a more mature consortium through procuring and implementing a shared LMS. The process has delivered tangible benefits and is driving more work to realise further benefits.

Research limitations/implications
As the WHELF Shared LMS project is only nearing the end of the implementation phase, many of the anticipated operational benefits cannot be reported.

Practical implications
Useful case study for other consortia or potential consortia.

Originality/value
WHELF is in vanguard of consortia developments in the UK, and this is the first case study of the project.
The future of workplace wellness programs
Authors: Ho Sam 
Published: February 2017

Purpose
A comprehensive look at how technology, health plan design and employee communication can improve workplace wellness programs.

Design/methodology/approach
There are numerous ways for employers to enhance their workplace wellness programs, helping to improve employee health and more effectively manage health-care costs.

Findings
There are numerous ways for employers to enhance their workplace wellness programs, helping to improve employee health and more effectively manage health-care costs.

Originality/value
The paper is original to Strategic HR Review.
Reduced inflammatory responses of follicular helper T cell promote the development of regulatory B cells after Roux‐en‐Y gastric bypass
Authors: Zhan Junfang , Huang Liyu , Ma Haiyong , Chen Huan , Yang Yuan , Tan Sheng , Song Wendy , Zhao Weiguo , Dai Xiaojiang 
Published: February 2017

SummaryBariatric surgery is currently the most effective strategy in treating severe obesity and its comorbidities, such as type 2 diabetes (T2D). However, the mechanism through which bariatric surgery mediates its benefits is not completely understood. Since obesity and T2D represent yet another inflammatory disease, and follicular helper T (Tfh) cells play important roles in inflammatory disorders, we investigated whether the Tfh activity was altered after Roux‐en‐Y gastric bypass (RYGB), one of the most common bariatric surgery procedures. We found that the Tfh cells after RYGB were not significantly changed in number, but presented altered cytokine secretion profile, including lower interferon (IFN)‐γ, interleukin (IL)‐2, IL‐4, and IL‐17 secretion. Tfh cells after RYGB also downregulated inducible co‐stimulator and programmed death‐1. Interestingly, after Tfh cell‐naive B cell coculture, Tfh cells after RYGB secreted more IL‐10 than autologous Tfh cells before RYGB. The frequencies of IL‐10‐expressing and transforming growth factor (TGF)‐β‐expressing regulatory B cells after Tfh cell‐naive B cell coculture were directly correlated with the frequency of IL‐10‐expressing Tfh cells. Depletion of IL‐10 in the coculture, however, resulted in fewer regulatory B cells. Finally, patients with greater increase in IL‐10‐expressing Tfh cells presented further reductions in body mass index, glycaemia, and body fat percentage. Together, these data demonstrated that the Tfh cells after RYGB presented lower inflammatory status and secreted higher IL‐10, through which these Tfh cells promoted the development of regulatory B cells. Higher IL‐10‐expressing Tfh cell level also predicted better patient response to RYGB.
Low‐dose rituximab and concurrent adjuvant therapy for pemphigus: Protocol and single‐centre long‐term review of nine patients
Authors: Robinson Aaron J , Vu Mi , Unglik Gary A , Varigos George A , Scardamaglia Laura 
Published: February 2017

AbstractPemphigus is an autoimmune B‐cell mediated blistering disease associated with significant morbidity and mortality. Rituximab has proven effective for the treatment of steroid‐refractory pemphigus, although there is controversy over the optimum dosing protocol. Additionally, effective disease control often requires long‐term immunosuppression, even in disease‐free periods. We present a case series of a single‐centre long‐term follow up of nine patients with pemphigus, treated with two 500‐mg doses of rituximab separated by 14 days along with concurrent adjuvant therapy. In all these patients, low‐dose rituximab resulted in B‐cell depletion, along with a reduction in blistering disease. Three of these patients required repeat dosing cycles due to either relapsed disease or incomplete disease control following the first dosing cycle, and have remained disease free up to 154 weeks thus far. Six patients developed minor infections during the course of their treatment, but no major complications were observed.
Variable Familial Exudative Vitreoretinopathy in a family harbouring variants in both FZD4 and TSPAN12
Authors: Schatz Patrik , Khan Arif O. 
Published: February 2017

AbstractPurposeTo report a family affected by familial exudative vitreoretinopathy (FEVR) in which more severe disease phenotypes segregated with digenic rather than monogenic variants in FEVR‐related genes.MethodsPhenotype was documented with high‐resolution imaging of retinal structure and wide‐field fundus photography. Next‐generation sequencing (NGS) of known genes involved in FEVR was performed.ResultsThree affected individuals within a family with FEVR presented with variable disease severity. All three affected family members harboured mutation c.349T>C (p.Cys117Arg) in FZD4. In addition, the youngest family member, a 9‐year‐old boy, who presented with bilateral tractional retinal detachment, and his mother, who presented with retinal pigmentary alterations and bilateral dragging of the macula and atrophy, both harboured the variant c.565T>C (p.Cys189Arg) in TSPAN12. Both suffered from bilateral severe visual loss. On the other hand, the older sister who presented with mild visual loss, temporal avascularity in the right eye and dragging of the blood vessels over the disc and macula in the left eye did not harbour the variant p.Cys189Arg in TSPAN12.ConclusionThese data suggest variants in more than one FEVR‐related gene can underlie variable expressivity for FEVR phenotypes in a single family. Further studies of phenotype–genotype correlation, including next‐generation sequencing, in larger cohorts of patients with FEVR are needed to investigate whether changes in more than one gene coding for proteins in the Norrin–β‐catenin pathway are a recurrent cause for variable expressivity in the disease.
Glomerular hyperfiltration is strongly correlated with age in Congolese children with sickle cell anaemia
Authors: Aloni Michel Ntetani , Ngiyulu René Makuala , Ekulu Pépé Mfutu , Mbutiwi Fiston IkwaNdol , Makulo Jean Robert , Gini‐Ehungu Jean Lambert , Nseka Nazaire Mangani , Lepira François Bompeka 
Published: February 2017

AbstractAimGlomerular hyperfiltration is an early marker of sickle cell nephropathy and can lead to microalbuminuria and renal failure. Our aim was to identify the associated risk factors, as these could be of preventative importance.MethodsWe recruited 150 children with sickle cell anaemia (SCA), aged two to 18 years and living in Kinshasa, the Democratic Republic of Congo. Hyperfiltration and microalbuminuria were defined as an estimated glomerular filtration rate of less than 140 mL/min/1.73 m² and an albumin creatinine ratio of between 30 and 299 mg/g, respectively. Independent determinants of hyperfiltration were assessed using logistic regression analysis.ResultsGlomerular hyperfiltration was observed in 60 (40%) children, who were significantly older (10.2 ± 4.1 versus 7.9 ± 4.3 years, p = 0.001) and had a lower body mass index level (14.7 ± 2.3 versus 15.0 ± 2.3 kg/m2) than the 60% without. A higher proportion had microalbuminuria (25.0 versus 13.3%), but the difference was not statistically significant (p>0.05). Increased age and decreased body mass index were the main independent factors associated with glomerular hyperfiltration in the multivariate analysis. A quarter (25%) of the 60 children with SCA with glomerular hyperfiltration had microalbuminuria.ConclusionGlomerular hyperfiltration was a common finding in this study and was significantly associated with age.
Real exchange rate fluctuations, wage stickiness and tradability
Authors: Naknoi Kanda 
Published: February 2017

AbstractWhen we classify factors of production by their tradability, the relative wage of nontraded labour influences the real exchange rate through the relative cost of distribution services. We confirm this prediction using monthly data on the sector‐level US–Canada real exchange rate and the relative wage of service‐producing labour. The relative wage accounts for 40% of the variability of the real exchange rate at a one‐month horizon. Furthermore, when we use the effective nontraded labour content to classify goods into nontraded and traded ones, the variability of the price of the nontraded‐goods basket accounts for more than half of the variability of the real exchange rate.
New vehicle feebates
Authors: Rivers Nicholas , Schaufele Brandon 
Published: February 2017

AbstractNew vehicle feebate programs encourage improved fleet‐wide vehicle fuel efficiency; yet analyses of these policies have been limited to ad hoc proposals. In this paper, we exploit an extensive, multi‐year dataset which includes more than 16 million observations to evaluate the welfare implications of a long‐standing vehicle feebate program in the Canadian province of Ontario. We: (1) show that second‐best optimal feebates can be written as a function of new vehicle Pigouvian taxes; (2) find that Ontario's feebate program was welfare‐enhancing relative to a no feebate scenario but that a second‐best optimal benchmark would have yielded additional welfare while reducing fleet‐wide emissions; and (3) find that Ontarian consumers responded asymmetrically to fees versus rebates.
Does caregiver participation in decision making within child welfare agencies influence children's primary and mental health care service use?
Authors: Jolles M. P. , Wells R. 
Published: February 2017

AbstractBackgroundMany children in contact with child welfare agencies do not receive needed health services. These agencies have used participatory decision making (PDM) practices as a way to increase families' use of recommended services. However, we lack evidence of whether caregiver participation in PDM increases children's use of health services. This study uses a national sample of children involved with child welfare to compare their health service use between those children serve through a PDM practice and those who did not experience it.MethodsCross‐sectional analyses using the 2009–2010 National Survey of Child and Adolescent Well‐Being. Propensity score analysis accounted for observed selection bias. PDM practice was measured as whether the caregiver was included in decision‐making during service planning meetings. Health service use was measured as child's receipt of any primary or mental health care services in the past year. Primary health care need was measured using standardized measures and caseworker report. The sample was comprised of children ages 2–17 with primary or mental health needs in contact with a child welfare agency.ResultsIn the unmatched sample of 1,358 children, 14% were served through a PDM service practice, and 12% had a primary health care and 37% a mental health need. Families served through PDM were also reported by caseworkers as more cooperative during the child welfare investigation, and with fewer reports of domestic violence and agency re‐referrals (P < 0.05). Analyses using matched samples showed that for primary health care, 59% of PDM children received services compared with 40% for non‐PDM children (P = 0.004). Group differences were not significant for mental health services.ConclusionsLower‐risk families were more likely to be served through PDM which was positively associated with child use of primary health services. Inclusion of caregivers in decision making may not be sufficient to overcome barriers to children's mental health service use.
The Development of Implicit Memory From Infancy to Childhood: On Average Performance Levels and Interindividual Differences
Authors: Vöhringer Isabel A. , Kolling Thorsten , Graf Frauke , Poloczek Sonja , Fassbender Ina , Freitag Claudia , Lamm Bettina , Suhrke Janina , Teiser Johanna , Teubert Manuel , Keller Heidi , Lohaus Arnold , Schwarzer Gudrun , Knopf Monika 
Published: February 2017

The present multimethod longitudinal study aimed at investigating development and stability of implicit memory during infancy and early childhood. A total of 134 children were followed longitudinally from 3 months to 3 years of life assessing different age‐appropriate measures of implicit memory. Results from structural equation modeling give further evidence that implicit memory is stable from 9 months of life on, with earlier performance predicting later performance. Second, it was found that implicit memory is present from early on, and no age‐related improvements are found from 3 months on. Results are discussed with respect to the basic brain structures implicit memory builds on, as well as methodological issues.
Civil society, social accountability and service delivery in Zimbabwe
Authors: Muchadenyika Davison 
Published: February 2017

AbstractPost‐2000, the deterioration of Zimbabwe's socioeconomic and political conditions is widely acknowledged as phenomenal and unprecedented. Consequently, government and local authorities are struggling to provide basic services. At the same time, civil society initiatives are promoting transparency and accountability in service delivery. The article explains how civil society coalitions and citizens are promoting and demanding accountability in the delivery of public services by local authorities. In particular, it focuses on four critical issues; namely local authority–citizen engagement, social accountability focus areas, social accountability tools and emerging social accountability issues. The article concludes that civil society‐led social accountability initiatives are effective under conditions of civil society capacity, institutionalization of social accountability by local authorities, and negotiating local political dynamics.
High‐temperature LCF life estimation based on stress gradient effect of notched GH4169 alloy specimens
Authors: Wang J. L. , Wei D. S. , Wang Y. R. , Zhong B. 
Published: February 2017

AbstractBased on the Neuber's rule and Walker equation, a new measurement method considering the influence of mean stress and stress gradient is proposed. A stress gradient factor is defined to correct the traditional Walker equation; thus, it is easy to estimate the life of the structural components only based on the purely elastic finite element analysis. The low‐cycle fatigue experiment was carried out by using the direct aging GH4169 notched specimen with different stress concentration factors under evaluated temperature. The fracture morphology of specimens was analyzed to determine the crack initiation position and the damage mechanism. The data points of the experiment life and the estimation life are correlated well within a three times scatter band. It indicates that the Walker equation corrected by introducing a new kind of measurement of stress gradient is reliable to estimate the notched specimen fatigue life.
The effectiveness of intravenous vitamin K in correcting cirrhosis-associated coagulopathy
Authors: Rivosecchi Ryan M , Kane-Gill Sandra L , Garavaglia Jeffrey , MacLasco Adam , Johnson Heather 
Published: February 2017

AbstractObjectivesThe goal of this study was to evaluate the effectiveness of intravenous (IV) vitamin K in cirrhosis.MethodsThis was a retrospective study of cirrhotic patients, not on anticoagulation, with administration of IV vitamin K and a baseline INR &gt; 1.5. The primary outcome was the effectiveness of therapy defined by a 30% decrease in INR or a reduction in INR to an absolute value of ≤1.5.Key FindingsA total of 96 patients were included in the cohort. There was an average decrease in INR of 0.31; however, 60 patients (62.3%) failed to achieve at least a 10% decrease. Sixteen patients (16.7%) met the primary effectiveness endpoint.ConclusionsThe use of IV vitamin K to correct coagulopathy of cirrhosis may not be beneficial.
A novel strategy to achieve NaGdF4:Eu3+ nanofibers with color‐tailorable luminescence and paramagnetic performance
Authors: Li Dan , Ma Qianli , Song Yan , Xi Xue , Dong Xiangting , Yu Wensheng , Wang Jinxian , Liu Guixia 
Published: February 2017

AbstractLuminescent‐magnetic bifunctional NaGdF4:Eu3+ nanofibers were fabricated through the bond of electrospinning followed by calcination with fluorination technology for the first time. The structure, morphologies, luminescence, and magnetism of nanofibers have been characterized using various techniques. X‐ray diffraction measurement indicates that NaGdF4:Eu3+ nanofibers are hexagonal phase. Scanning electron microscope measurement shows that the mean diameters of electrospinning‐made polyvinyl pyrrolidone/[NaNO3+Gd(NO3)3+Eu(NO3)3] composite nanofibers and NaGdF4:Eu3+ nanofibers are, respectively, 428±4 and 231±4 nm under the confidence level of 95%. Under 274‐nm ultraviolet light excitation, NaGdF4:Eu3+ nanofibers exhibit characteristic 5D3,2,1,0→7FJ emissions of Eu3+ and the tendency of color tones of samples varies from blue, cold white, warm white to red via varying Eu3+ content. In addition, samples exhibit paramagnetic features and the magnetic properties of NaGdF4:Eu3+ nanofibers are tailorable by modulating the doping concentration of Eu3+. More importantly, the color‐tailorable luminescence and paramagnetic properties are simultaneously realized in single‐phase NaGdF4:Eu3+ nanofibers, which ideally suit to apply in many fields such as lighting and color displays, bioimaging, and magnetic resonance imaging. This design conception and construction strategy may provide some new guidance for synthesizing other rare‐earth fluorides nanomaterials of multifarious morphologies.
Experimental synthesis and density functional theory investigation of radiation tolerance of Zr3(Al1‐xSix)C2MAX phases
Authors: Zapata‐Solvas Eugenio , Christopoulos Stavros‐Richard G. , Ni Na , Parfitt David C. , Horlait Denis , Fitzpatrick Michael E. , Chroneos Alexander , Lee William E. 
Published: February 2017

AbstractSynthesis, characterization and density functional theory calculations have been combined to examine the formation of the Zr3(Al1–xSix)C2 quaternary MAX phases and the intrinsic defect processes in Zr3AlC2 and Zr3SiC2. The MAX phase family is extended by demonstrating that Zr3(Al1–xSix)C2, and particularly compositions with x≈0.1, can be formed leading here to a yield of 59 wt%. It has been found that Zr3AlC2 ‐ and by extension Zr3(Al1–xSix)C2 ‐ formation rates benefit from the presence of traces of Si in the reactant mix, presumably through the in situ formation of ZrySiz phase(s) acting as a nucleation substrate for the MAX phase. To investigate the radiation tolerance of Zr3(Al1–xSix)C2, we have also considered the intrinsic defect properties of the end‐members. A‐element Frenkel reaction for both Zr3AlC2 (1.71 eV) and Zr3SiC2 (1.41 eV) phases are the lowest energy defect reactions. For comparison we consider the defect processes in Ti3AlC2 and Ti3SiC2 phases. It is concluded that Zr3AlC2 and Ti3AlC2 MAX phases are more radiation tolerant than Zr3SiC2 and Ti3SiC2, respectively. Their applicability as cladding materials for nuclear fuel is discussed.