bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior
Authors: Jones Brandon C. , Kelley Laura C. , Loskutov Yuriy V. , Marinak Kristina M. , Kozyreva Varvara K. , Smolkin Matthew B. , Pugacheva Elena N. 
Published: February 2017

Abstract
Commonly upregulated in human cancers, the scaffolding protein NEDD9/HEF1 is a known regulator of mesenchymal migration and cancer cell plasticity. However, the functional role of NEDD9 as a regulator of different migration/invasion modes in the context of breast cancer metastasis is currently unknown. Here, it is reported that NEDD9 is necessary for both mesenchymal and amoeboid individual cell migration/invasion in triple-negative breast cancer (TNBC). NEDD9 deficiency results in acquisition of the amoeboid morphology, but severely limits all types of cell motility. Mechanistically, NEDD9 promotes mesenchymal migration via VAV2-dependent Rac1 activation, and depletion of VAV2 impairs the ability of NEDD9 to activate Rac1. In addition, NEDD9 supports a mesenchymal phenotype through stimulating polymerization of actin via promoting CTTN phosphorylation in an AURKA-dependent manner. Interestingly, an increase in RhoA activity in NEDD9-depleted cells does not facilitate a switch to functional amoeboid motility, indicating a role of NEDD9 in the regulation of downstream RhoA signaling effectors. Simultaneous depletion of NEDD9 or inhibition of AURKA in combination with inhibition of the amoeboid driver ROCK results in an additional decrease in cancer cell migration/invasion. Finally, we confirmed that a dual targeting strategy is a viable and efficient therapeutic approach to hinder the metastasis of breast cancer in xenograft models, showcasing the important need for further clinical evaluation of this regimen to impede the spread of disease and improve patient survival.
Implications: This study provides new insight into the therapeutic benefit of combining NEDD9 depletion with ROCK inhibition to reduce tumor cell dissemination and discovers a new regulatory role of NEDD9 in the modulation of VAV2-dependent activation of Rac1 and actin polymerization. Mol Cancer Res; 15(6); 670–82. ©2017 AACR.
<b>New records of Aplousobranch ascidians to Indian waters from Andaman Islands</b>
Authors: Mondal Jhimli , Raghunathan C. , Venkataraman K. 
Published: February 2017

Aplousobranchia represents the largest order under the class Ascidiacea. Two reef associated aplousobranch ascidians, Rhopalaea macrothorax Tokioka, 1953 under the family Diazonidae and Clavelina robusta Kott, 1990 under the family Clavelinidae, found from the Andaman group of islands are reported as new records to the Indian waters. The present paper describes the taxonomic characters and distribution of these two newly recorded species.
<b>Additions to the scorpion fauna (Arachnida: Scorpiones) of Kerala, India, with an illustrated key to the genera</b>
Authors: Aswathi K. , Sureshan P. M. 
Published: February 2017

Twospecies of scorpions ( Arachnida : Scorpiones) viz., LychaslaevifronsPocock and Heterometrus flavimanus (Pocock) are reported for the first time form Kerala and an illustrated key to the genera and checklist of scorpion species of Kerala are provided. Currently 21species under 09genera of scorpions are known from the state.
<b>A report on occurrence of aphidophagous predators of <I>Aphis odinae</I> (van der Goot) (Hemiptera: Aphididae) in cashew ecosystem from Goa, India</b>
Authors: Maruthadurai Ramasamy , Singh Narendra Pratap 
Published: February 2017

The aphid, Aphis odinae (Van der Goot) (Hemiptera: Aphididae) is a polyphagous, occasional insect pest of cashew. A field survey was conducted from 2014 to 2015 in cashew plantations to record the incidence of aphid and its predators. Periodical sampling revealed, the occurrence of six species of aphidophagous predators comprising three species of coccinellids, viz., Scymnus castaneus Sicard, Cheilomenes sexmaculata (Fabricius) and Pseudaspidimerus flaviceps (Walker) and three species of syrphids, viz., Paragus serratus (Fabricius), Dideopsis aegrota (Fabricius) and Ischidon scutellaris (Fabricius) were found predating on A. odinae. All the immature stages of predators were found predating on first, second, third and fourth instars of the aphid. Among the coccinellids, the dominant species were S. castaneus (4.26 grubs/nut) followed by C. sexmaculata (0.42 grubs/leaf) and P. flaviceps (0.14 grubs/nut). Of the syrphids, P. serratus 2.39 larvae/nut was the major predator. The species D. aegrota (1.2 larvae/leaf) and I. scutellaris (0.5 larvae/nut) were recorded as minor predators. Seasonal abundance of predators was synchronized with the aphid with a maximum occurrence during February 2015. The aphid population gradually reduced from April onwards due to the voracious feeding activity of the predators. The study concluded that the aphidophagous predators, viz., coccinellids and syrphids play a major role in managing the aphid A. odinae in cashew and could be encouraged for augmentation and conservation of these predators in a cashew based ecosystem.
<b>Moths of the family Limacodidae Duponchel, 1845 (Lepidoptera: Zygaenoidea) from Bhutan with six new generic and 12 new species records</b>
Authors: Irungbam Jatishwor Singh , Chib Meenakshi Singh , Solovyev Alexey V. 
Published: February 2017

The present paper provides a checklist of 51 species in 37 genera of moths belonging to the family Limacodidae from Bhutan, of which, six genera, Setora Walker, 1855, Tennya Solovyev & Witt, 2009, Iraga Matsumura, 1927, Vanlangia Solovyev & Witt 2009, Sansarea Solovyev & Witt, 2009, and Belippa Walker, 1865 are reported for the first time from Bhutan, and 12 species, Setora postornata (Hampson, 1900), Setora fletcheri Holloway, 1987, Scopelodes testacea Butler, 1886, Thosea magna Hering, 1931, Miresa fulgida Wileman, 1910, Susica himalayana Holloway, 1982, Tennya propolia (Hampson, 1900), Iraga rugosa (Wileman, 1911), Cheromettia ferruginea (Moore, 1877), Vanlangia uniformis (Hering, 1931), Sansarea circulifera (Hering, 1933) and Belippa horrida Walker, 1865 are new records for Bhutan. The study was conducted at Tsirang, Dagana and Sarpang districts of Bhutan from 2013 to 2015.
<b>Diversity of two families Libellulidae and Coenagrionidae (Odonata) in Regional Institute of Education Campus, Bhubaneswar, Odisha, India</b>
Authors: Pandey Priyamvada , Mohapatra Animesh Kumar 
Published: February 2017

Libellulidae and Coenagrionidae are the most dominant families among dragonflies and damselflies. The present study deals with the diversity, occurrence and present status of libellulids and coenagrionids within the Regional Institute of Education Campus in Bhubaneswar, Odisha, India (RIEC). The major objectives of this study are to prepare a preliminary checklist of libellulids and coenagrionids species in the RIEC and to find out the status and distribution of genera and species in their respective families. This study is also aimed at systematic planning for developing different strategies for conservation of odonates in the campus. During this study a total of 24 species have been recorded out of which 20 species belong to the family Libellulidae representing 15 genera and four species belong to the family Coenagrionidae representing four genera. The findings of this study are based on the survey which was carried out for a period of four months in 2015.
<b>On the feeding habit of the Guiana Dolphin Sotalia guianensis (van Bénedèn, 1864) (Mammalia: Cetartiodactyla: Delphinidae) in southeastern Brazil (~220S): has there been any change in more than two decades?</b>
Authors: Di Beneditto Ana Paula Madeira , Badia Clara Da Cruz Vidart , Siciliano Salvatore 
Published: February 2017

Along the north and central coast of Rio de Janeiro State (22025’S–23000’S), southeastern Brazil, the Guiana Dolphin Sotalia guianensis forages on neritic prey, mainly fish. From the analysis of the dolphin’s stomach contents and the identification of partially digested prey, it was verified that the most frequent prey species were young specimens of Trichiurus lepturus. Comparing our results with previous studies on the feeding habits of Guiana Dolphin in the same region, we noticed the maintenance of its feeding preferences during more than two decades, indicating little or no change in the use of prey by this top predator.
<b>A century later the Manipur Argus <I>Callerebia suroia</I> Tytler, 1914 (Lepidoptera: Nymphalidae: Satyrinae) recorded in its type locality in Manipur, India</b>
Authors: Irungbam Jatishwor Singh , Huidrom Harmenn , Soibam Baleshwor Singh 
Published: February 2017

The present paper reports the sighting of Callerebia suroia Tytler, 1914 at Shirui Kashong Peak, Ukhrul District which confirms the continued presence of the species in Manipur State, India. The butterfly was sighted on 13 July 2016 near the footpath leading to the summit at an altitude of 2,330m. Callerebia suroia Tytler, 1914 is protected under Schedule II of the Indian Wildlife (Protection) Act 1972. The sighting of such very rare species in Manipur after a decade shows that more surveys are needed in the hills and valleys of Manipur to determine the butterfly fauna of the region.
<b>Odonates of Coimbatore District, Tamil Nadu, India</b>
Authors: Muhil M. Suhirtha , Pramod P. 
Published: February 2017

Odonates were surveyed in Coimbatore District from September 2012 to January 2016. The survey sites covered three major rivers—the Noyyal, Bhavani and Aliyar. Aquatic habitats such as forest streams, riverine sites, irrigational tanks and paddy fields were surveyed in the study. A total of 70 species of odonates were recorded in the survey, which brings the list of odonates in Coimbatore to 87 species. Eighteen species are first time records to the district. In this paper, we catalogue odonates and their distribution from the present survey and pre-existing records.
<b>First record of the predatory stinkbug <I>Eocanthecona concinna</I> (Walker, 1867) (Pentatomidae: Asopinae) from India</b>
Authors: Waghmare Sadashiv Hanumant , Gaikwad Sunil Madhukar 
Published: February 2017

The genus Eocanthecona is distributed in oriental, Ethiopian and Australasian regions. This genus is represented by 24 species from the world of which only five species are reported from India. The bug Eocanthecona concinna was first reported from Hong Kong, China in 1867. Later again reported from different regions of China and Taiwan in 1910, 1934, 1961 and 2013. The review of literature indicates no record of E. concinna in India. Hence, the report of this stinkbug from Kolhapur becomes first report for India and the geographic range of the species in China and Taiwan is extended towards India.
<b>Flora richness as an indicator of desert habitat quality in Kuwait</b>
Authors: Al-Shehabi Yahya , Murphy Kevin 
Published: February 2017

An assessment of the vegetation in the arid desert habitats of Kuwait was carried out in 2008 and 2009. The richness of vegetation was examined in relation to human activity (e.g., grazing, recreational camping) and impact factors in two open areas (north of SAANR, NS; south of Kabd, SK) were compared with two protected areas (SAANR, Kabd). In total, 420 quadrats were sampled along 84 transects at random locations along off-road vehicle tracks in the study area. The data were classified using two-way indicator species analysis (TWINSPAN) to divide samples into three groups of high internal similarity in terms of plant species presence. Total plant species richness was 20, 35, 2 and 17 species per area in SAANR, Kabd, NS and SK, respectively. Compared to protected areas, open grazed land had markedly fewer species and reduced vegetation cover in the form of grasses, forbs and shrubs. Habitat conditions were especially impoverished in NS, with 99% of samples supporting only one plant species. The low plant diversity in the unprotected open rangelands demonstrates the need for a new strategy to rehabilitate ecological habitats.
Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study
Authors: Hu Sining , Zhu Yinchun , Zhang Yingying , Dai Jiannan , Li Lulu , Dauerman Harold , Soeda Tsunenari , Wang Zhao , Lee Hang , Wang Chao , Zhe Chunyang , Wang Yan , Zheng Gonghui , Zhang Shaosong , Jia Haibo , Yu Bo , Jang Ik‐Kyung 
Published: February 2017

Background
Plaque rupture and erosion are the 2 most common mechanisms for acute coronary syndromes. However, the outcome of these 2 distinct pathologies in patients with acute coronary syndromes has never been studied.

Methods and Results

We retrospectively studied 141 patients with acute coronary syndromes who underwent optical coherence tomography (
OCT
) imaging of the culprit lesion prior to stenting from the Massachusetts General Hospital
OCT
Registry. Management (stent versus no stent), poststent
OCT
findings, and outcomes were compared. Among the 141 culprit lesions, rupture was found in 79 (56%) patients and erosion in 62 (44%). Stent implantation was performed in 77 (97.5%) patients with rupture versus 49 (79.0%) in those with erosion (
P
<0.001). Immediately after percutaneous coronary intervention,
OCT
showed a higher incidence of malapposition (37.5% versus 7.3%,
P
<0.001), thrombus (59.4% versus 14.6%,
P
<0.001), and protrusion (93.8% versus 73.2%,
P
=0.008) in the rupture group compared with the erosion group. Plaque rupture was associated with a higher incidence of no reflow or slow flow and distal embolization. Although cardiac event rates were comparable between the two groups at the 1‐year follow‐up, none of the erosion patients who were treated conservatively without stenting had adverse cardiac events.

Conclusions

Unfavorable poststent
OCT
findings were more frequent in rupture patients compared with erosion patients. A subset of erosion patients who were treated conservatively without stenting remained free of adverse cardiac events for up to 1 year.
Prehospital Emergency Care in Childhood Arterial Ischemic Stroke
Authors: Stojanovski Belinda , Monagle Paul T. , Mosley Ian , Churilov Leonid , Newall Fiona , Hocking Grant , Mackay Mark T. 
Published: February 2017

Background and Purpose—
Immediately calling an ambulance is the key factor in reducing time to hospital presentation for adult stroke. Little is known about prehospital care in childhood arterial ischemic stroke (AIS). We aimed to determine emergency medical services call-taker and paramedic diagnostic sensitivity and to describe timelines of care in childhood AIS.

Methods—
This is a retrospective study of ambulance-transported children aged <18 years with first radiologically confirmed AIS, from 2008 to 2015. Interhospital transfers of children with preexisting AIS diagnosis were excluded.

Results—
Twenty-three children were identified; 4 with unavailable ambulance records were excluded. Nineteen children were included in the study. Median age was 8 years (interquartile range, 3–14); median Pediatric National Institutes of Stroke Severity Scale score was 8 (interquartile range, 3–16). Emergency medical services call-taker diagnosis was stroke in 4 children (21%). Priority code 1 (lights and sirens) ambulances were dispatched for 13 children (68%). Paramedic diagnosis was stroke in 5 children (26%), hospital prenotification occurred in 8 children (42%), and 13 children (68%) were transported to primary stroke centers. Median prehospital timelines were onset to emergency medical services contact 13 minutes, call to scene 12 minutes, time at scene 14 minutes, transport time 43 minutes, and total prehospital time 71 minutes (interquartile range, 60–85).

Conclusions—
Emergency medical services call-taker and paramedic diagnostic sensitivity and prenotification rates are low in childhood AIS.
Successful Reperfusion With Mechanical Thrombectomy Is Associated With Reduced Disability and Mortality in Patients With Pretreatment Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Score ≤6
Authors: Desilles Jean-Philippe , Consoli Arturo , Redjem Hocine , Coskun Oguzhan , Ciccio Gabriele , Smajda Stanislas , Labreuche Julien , Preda Cristian , Ruiz Guerrero Clara , Decroix Jean-Pierre , Rodesch Georges , Mazighi Mikael , Blanc Raphaël , Piotin Michel , Lapergue Bertrand , Wang Adrien , Evrard Serge , Tchikviladzé Maya , Bourdain Frederic , Gonzalez-Valcarcel Jaime , Di Maria Federico , Pico Fernando , Rakotoharinandrasana Haja , Tassan Philippe , Poll Roxanna , Corabianu Ovide , de Broucker Thomas , Smadja Didier , Alamowitch Sonia , Obadia Michael , Ille Olivier , Manchon Eric , Garcia Pierre-Yves 
Published: February 2017

Background and Purpose—
In acute ischemic stroke patients, diffusion-weighted imaging (DWI)–Alberta Stroke Program Early Computed Tomography Score (ASPECTS) is correlated with infarct volume and is an independent factor of functional outcome. Patients with pretreatment DWI-ASPECTS ≤6 were excluded or under-represented in the recent randomized mechanical thrombectomy trials. Our aim was to assess the impact of reperfusion in pretreatment DWI-ASPECTS ≤6 patients treated with mechanical thrombectomy.

Methods—
We analyzed data collected between January 2012 and August 2015 in a bicentric prospective clinical registry of consecutive acute ischemic stroke patients treated with mechanical thrombectomy. Every patient with a documented internal carotid artery or middle cerebral artery occlusion with pretreatment DWI-ASPECTS ≤6 was eligible for this study. The primary end point was a favorable outcome defined by a modified Rankin Scale score ≤2 at 90 days.

Results—

Two hundred and eighteen patients with a DWI-ASPECTS ≤6 were included. Among them, 145 (66%) patients had successful reperfusion at the end of mechanical thrombectomy. Reperfused patients had an increased rate of favorable outcome (38.7% versus 17.4%;
P
=0.002) and a decreased rate of mortality at 3 months (22.5% versus 39.1%;
P
=0.013) compared with nonreperfused patients. The symptomatic intracranial hemorrhage rate was not different between the 2 groups (13.0% versus 14.1%;
P
=0.83). However, in patients with DWI-ASPECTS <5, favorable outcome was low (13.0% versus 9.5%;
P
=0.68) with a high mortality rate (45.7% versus 57.1%;
P
=0.38) with or without successful reperfusion.

Conclusions—
Successful reperfusion is associated with reduced mortality and disability in patients with a pretreatment DWI-ASPECTS ≤6. Further data from randomized studies are needed, particularly in patients with DWI-ASPECTS <5.
Distributions of Subclinical Cardiovascular Disease in a Socioeconomically and Racially Diverse Sample
Authors: Wendell Carrington R. , Waldstein Shari R. , Evans Michele K. , Zonderman Alan B. 
Published: February 2017

Background and Purpose—
Differential subgroup vulnerability to subclinical cardiovascular disease is likely, and yet few, if any, studies have addressed interactive relations of age, sex, race, and socioeconomic status (SES) to these conditions to examine nuances of known health disparities. We examined distributions of carotid atherosclerosis and arterial stiffness in a socioeconomically diverse, biracial, urban sample.

Methods—
Participants (n=2270) in the population-based HANDLS study (Healthy Aging in Neighborhoods of Diversity Across the Life Span; 30–64 years old, 44% men, 57% African American, 39% with household income <125% federal poverty threshold) underwent carotid intimal medial thickness (IMT) and pulse wave velocity assessment.

Results—
In cross-sectional hierarchical regression analyses, interactive race×SES effects were identified for IMT and pulse wave velocity, such that high SES African Americans had significantly thicker IMTs and faster pulse wave velocities than all other subgroups (ie, low SES African Americans, low SES whites, and high SES whites). A race×sex effect was also identified for IMT, such that the IMT discrepancy between white men and women was more pronounced than the discrepancy between African American men and women. Finally, an SES×sex effect indicated that while IMTs of high SES and low SES men did not significantly differ, high SES women had marginally thicker IMTs than low SES women.

Conclusions—
High SES African Americans may be particularly vulnerable to subclinical cardiovascular diseases, placing them at enhanced risk for clinical cardiovascular diseases, including stroke. These findings suggest that male sex, low SES, and African American ancestry may represent imprecise generalizations as risk factors for subclinical cardiovascular disease.
Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke
Authors: Jing Jing , Pan Yuesong , Zhao Xingquan , Zheng Huaguang , Jia Qian , Mi Donghua , Chen Weiqi , Li Hao , Liu Liping , Wang Chunxue , He Yan , Wang David , Wang Yilong , Wang Yongjun 
Published: February 2017

Background and Purpose—
Insulin resistance was common in patients with stroke. This study investigated the association between insulin resistance and outcomes in nondiabetic patients with first-ever acute ischemic stroke.

Methods—
Patients with ischemic stroke without history of diabetes mellitus in the ACROSS-China registry (Abnormal Glucose Regulation in Patients With Acute Stroke Across China) were included. Insulin resistance was defined as a homeostatis model assessment–insulin resistance (HOMA-IR) index in the top quartile (Q4). HOMA-IR was calculated as fasting insulin (μU/mL)×fasting glucose (mmol/L)/22.5. Multivariable logistic regression or Cox regression was performed to estimate the association between HOMA-IR and 1-year prognosis (mortality, stroke recurrence, poor functional outcome [modified Rankin scale score 3–6], and dependence [modified Rankin scale score 3–5]).

Results—

Among the 1245 patients with acute ischemic stroke enrolled in this study, the median HOMA-IR was 1.9 (interquartile range, 1.1–3.1). Patients with insulin resistance were associated with a higher mortality risk than those without (adjusted hazard ratio, 1.68; 95% confidence interval, 1.12–2.53;
P
=0.01), stroke recurrence (adjusted hazard ratio, 1.57, 95% confidence interval, 1.12–2.19;
P
=0.008), and poor outcome (adjusted odds ratio, 1.42; 95% confidence interval, 1.03–1.95;
P
=0.03) but not dependence after adjustment for potential confounders. Higher HOMA-IR quartile categories were associated with a higher risk of 1-year death, stroke recurrence, and poor outcome (
P
for trend =0.005, 0.005, and 0.001, respectively).

Conclusions—
Insulin resistance was associated with an increased risk of death, stroke recurrence, and poor outcome but not dependence in nondiabetic patients with acute ischemic stroke.
Cerebral Arteriovenous Malformation Flow Is Associated With Venous Intimal Hyperplasia
Authors: Shakur Sophia F. , Hussein Ahmed E. , Amin-Hanjani Sepideh , Valyi-Nagy Tibor , Charbel Fady T. , Alaraj Ali 
Published: February 2017

Background and Purpose—
The pathogenesis of venous intimal hyperplasia and venous outflow stenosis associated with cerebral arteriovenous malformation (AVM) draining veins is poorly understood. We sought to determine the relationship between maximum vein wall thickness and AVM flow.

Methods—
Patients who underwent AVM surgical resection and had flow measured before treatment using quantitative magnetic resonance angiography were retrospectively reviewed. Specimens were mounted on slides and stained with elastin special stain. Perinidal veins were identified, and maximum wall thickness was measured from digitized images. Relationship between maximum vein wall thickness and AVM flow was assessed.

Results—

Twenty-eight patients were included. Spearman correlation revealed a statistically significant relationship between maximum vein wall thickness and total AVM flow (ρ=+0.51;
P
=0.006), AVM flow per draining vein (ρ=+0.41;
P
=0.03), and mean intranidal vessel diameter (ρ=+0.39;
P
=0.04).

Conclusions—
Maximum vein wall thickness increases with higher total AVM flow and AVM flow per draining vein. This finding implicates chronically high AVM inflow in venous intimal hyperplasia.