bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hipertensión arterial, dislipidemia y obesidad en pacientes diabéticos tipo 2 que consultaron en un hospital de Paraná, Entre Ríos, Argentina
Authors: Gómez Marisa Ileana , Genzelis Mariana Clara 
Published: September 2024

Introducción. La diabetes es una enfermedad crónica metabólica, caracterizada por altos niveles de glucosa en sangre, que afecta la micro y la macrocirculación. Las comorbilidades más comunes en los diabéticos son las que corresponden al síndrome metabólico. Los objetivos de esta investigación fueron conocer la prevalencia de hipertensión arterial, dislipidemia y obesidad en pacientes con diabetes tipo 2 atendidos en un hospital de Paraná, Entre Ríos, durante el período comprendido entre los años 2018 y 2023, y recabar información sobre estos pacientes (edad, sexo, años de evolución, índice de masa corporal, control metabólico, complicaciones, comorbilidades, fármacos utilizados, tabaquismo).Metodología. Estudio retrospectivo, descriptivo de corte transversal de historias clínicas digitales de pacientes diabéticos que consultaron en un hospital de la ciudad de Paraná durante los años 2018 y 2023, con un muestreo de tipo aleatorio simple.Resultados. Se incluyeron cien pacientes con una edad media de 60,6 (DE 10,6) años, de los cuales el 51 % eran mujeres y el 49 %, hombres, la mayoría con diagnóstico reciente (<10 años) y la mitad de ellos sin un correcto control metabólico. El 87 % de los pacientes tenía hipertensión arterial, el 90 % tenía dislipidemia y el 61 % tenía obesidad; el 98 % tenía síndrome metabólico. El 43 % tenía alguna complicación por la diabetes, siendo la más frecuente la nefropatía diabética (22 %). El tratamiento antidiabético más elegido fue la administración de antidiabéticos orales, en especial la metformina; el antihipertensivo, los inhibidores de la enzima convertidora de angiotensina; y el hipolipemiante, las estatinas. El 42 % de los pacientes fumaban o fumaron alguna vez.Conclusión. La amplia mayoría de los pacientes presentaba dos o más factores de riesgo cardiovascular. Los pacientes con mal control metabólico tenían mayor frecuencia de complicaciones.
ANALYZING WHEAT VARIETY NAWAB-21 FOR AGRONOMIC, PATHOLOGICAL AND ZINC BIOFORTIFICATION ATTRIBUTES UNDER MULTILOCATIONAL TRIALS
Authors: Mahmood Khalid , Mashal Rehman  , Imtiaz Ali  , Rana Imtiaz Ahmed  , Akash Zafar  , Natasha Kanwal  , Abdul Majid Khan  , Muhammad Arshad Hussain  , Abid Ali  , Naeem Arshad Maan  , Muhammad Imran Akhtar  , Asad-ur-Rahman Ch.  , Wajiha Anum  , Madiha Mobeen Khan  , Nadia Manzoor  
Published: September 2024

Wheat variety Nawab-21 is one of the elite genotypes of CIMMYT germplasm Harvest plus yield trial (7-HPYT, 2016-17) with high zinc contents and more yield potential as compared to earlier evolved biofortified and non-biofortified wheat varieties. The variety was initially screened out at the Regional Agricultural Research Institute, Bahawalpur, Pakistan in station yield trials, where it gave 5537 kg ha-1grain yield which was 11% higher than the check varieties. In multi-locational yield trials, the variety’s yield potential was recorded as 7007 kg ha-1 in Alipur region. The variety also came-up when tested in National Wheat Disease Screening Nursery’s (NWDSN) for disease (rusts) resistance in both years of national uniform wheat yield trials (NUWYT 2019-20 and 2020-21). Nawab-21 is medium in maturity with head emerging from the flag leaf between 90-95 days and matures within 140-145 days.
FOOD METABOLISM AND OBESITY. REPORT 2 (CONSUMPTION, DEPOSIT, SPENDING)
Authors:   Irkutsk State Medical University, Maiboroda Askold A 
Published: September 2024

Background. The high percentage of people with overweight and obesity is a social problem almost all over the world. The main cause of obesity is overeating. Understanding the pattern of gradual food intake, its expenditure and deposi-tion is the basis of rational nutrition. Results. The lecture presents the order of macronutrient utilization in the process of abdominal and cellular digestion. It is shown that the utilization of proteins, lipids and polysaccharides occurs by changing sequential states: poly-mer ↔ monomer. The deposition of polymers and oxidation of monomers has organ specificity, while the deposition of glycogen is limited, and the deposition of fats is carried out proportionally to the excess of consumed macronutrients. Under conditions of regular and frequent nutrition, the needs of the basal metabolism are provided by glycogenolysis and glycolysis. Under conditions of fasting and physical activity, fats become in demand, which through hydrolysis and subsequent oxidation of fatty acids, are converted into acetyl-CoA and are used in the tricarboxylic acid cycle. Under conditions of regular, excessive nutrition and low physical activity, adipocyte triglycerides are required by the body only for the basal metabolism. The deposition of food organic by the human body ensures the continuous need of vital activity under conditions of peri-odic food intake. The deposited reserve guarantees the state of homeostasis. The volumes of carbohydrate deposition are strictly controlled, but the volumes of deposited fats can significantly exceed their reserve needs. Under conditions of frequent and abundant nutrition, adipocyte fats are practically not in demand by the body, and the excess of con-sumed proteins, lipids and carbohydrates are converted into fats. The expenditure of nutrients consumed by a person is controlled by the basal metabolism, thermogenesis and psy-chophysical activity. People cannot control the basal metabolism. It ensures the very existence of a person (gas exchange, blood circulation, excretion, cellular homeostasis, etc.). A person can control the volume of food consump-tion and include expenditure on bursts of muscle activity – there are receptors for adrenaline in muscles. Adrenaline stimulates glycolysis in muscle cells and lipolysis in adipocytes. Increased physical activity and fasting are the only ways in which a person can “include” the expenditure of triglycerides. Conclusion. When the body’s expenditure on basic metabolism, thermogenesis and psychophysical activity is satis-fied, the deposit system automatically, without our conscious participation, deposits triglycerides in volume of more than half of the dry body mass. There are simply no other ways to control food surpluses in the body. All food surpluses are deposited in fats.
Le discours actuel sur les transclasses et les autosociobiographies en France et en Allemagne : un entre-deux à bien des égards
Authors: Schuhen Gregor 
Published: September 2024

L’article aborde tout d'abord la thèse selon laquelle les autosociobiographies constituent une forme narrative hybride qui peut très bien être caractérisée par le modèle de l’« entre-deux ». On peut constater que les récits autosociobiographiques franchissent les frontières entre la littérature et les sciences sociales, en racontant des parcours personnels dans le miroir d’un diagnostic socio-analytique. Au niveau du texte, le caractère hybride peut également être démontré à l’aide des protagonistes transclasses car des individus passent d’un milieu d’origine populaire à la bourgeoisie. Sur le plan narratologique, ce caractère « entre-deux » se manifeste à travers le statut du narrateur autodiégétique : le « je » narré est représentatif du milieu d’origine modeste, tandis que le « je » narrateur a déjà pris pied dans le milieu bourgeois. Ces deux niveaux du « je » se rapprochent de plus en plus au fil du récit autosociobiographique, ce qui reflète aussi la mobilité sociale des protagonistes.Dans un deuxième temps, l’accent est mis sur le discours sur les transclasses et la réception des autosociobiographies, en adoptant une perspective comparative entre la France et l’Allemagne. Il s’avère que les débats en France sont bien plus controversés qu’en Allemagne. Cela s’explique d’une part par le fait que les autosociobiographies ont une tradition nettement plus longue en France, alors qu’elles n’ont été découvertes en Allemagne qu’à partir de 2016 et que le courant ne s’est imposé que lentement. Qui plus est, l’acuité des débats en France est due au fait que les catégories sociales de classe et du milieu d’origine ont été intégrées dans les controverses générales sur les politiques d’identité, ce que l’on ne peut pas (encore) observer en Allemagne en 2023/2024.La dernière étape consiste à expliquer dans quelle mesure le fait que de nombreux auteurs transclasses se considèrent comme des ‘héritiers’ de Bourdieu est également en partie responsable des débats parfois âpres qui ont lieu en France. Le fait que Bourdieu ait lui-même une biographie transclasse et que ses recherches et son engagement social aient déjà fait l’objet de vives critiques de son vivant de la part des représentants conservateurs de sa discipline et aussi des médias conservateurs est sans doute l’une des raisons pour lesquelles ses héritiers autoproclamés doivent eux aussi faire face à tant de vents contraires.
Pernikahan Mualaf Belum Sirkumsisi (Khitan) Dalam Islam
Authors: Burhan Ali , Arifin Samsul 
Published: September 2024

Abstract
This journal discusses the issue of the validity of marriage for a convert to Islam who has not yet circumcised (circumcision). The results of the research can be presented or explained in this journal that marriage for someone, especially for converts who have not been circumcised (Circumcision) is still considered valid as long as the conditions and harmony in marriage are fulfilled. Because the ulama do not require circumcision (Circumcision) as a condition for marriage. Likewise, in the law of circumcision (Circumcision) there are differences of opinion among the priests of the sect.
Jurnal ini membahas tentang permasalahan keabsahan pernikahan bagi seorang mualaf yang belum sirkumsisi ( khitan ). Adapun hasil penelitian dapat dipaparkan atau dijelaskan dalam jurnal ini bahwa pernikahan bagi seseorang khususnya bagi mualaf yang belum sirkumsisi ( Khitan ) tetap dihukumi sah selama syarat dan rukun dalam pernikahan terpenuhi. Karena para ulama tidak mensyaratkan kepada sirkumsisi ( Khitan ) sebagai sebuah syarat dalam pernikahan. begitu pula di dalam hukum sirkumsisi ( Khitan ) terdapat perbedaan pendapat di kalangan para imam mazhab.
Analysis of the Patriotic Health Movement in China: A Study on the Crude Health Movement.
Authors: Shan Chonghe 
Published: September 2024

Due to multifaceted pressures encountered in developing countries, there exists significant resistance towards implementing public medical activities, particularly due to the contradictions arising from limited educational attainment. This paper commences by examining the patriotic health movement in China during the 1950s as a means of identifying solutions to these challenges. It initially reviews the difficulties faced by the Chinese government during the patriotic health campaign and explores potential remedies, subsequently assessing their applicability in contemporary times. An analysis of public health responses in various developing nations over recent years reveals that many seemingly rudimentary approaches remain highly effective today.
Making Molecular Tools to Determine the Effect of Amino Acid Supply on Protein Synthesis
Authors: Yang Yutong 
Published: September 2024

Background: The twenty amino acids making up proteins in animals are classified into three nutritional classes: EAAs, NEAAs and CEAAs. Proteins with extreme amino acid ratios are closely related to growth, malnourishment, cancer and other health problems. Previous studies have shown that the amino acid composition of a protein can influence the protein expression level. The hypothesis that CEAA-rich proteins tend to reduce expression, especially in cells proliferating quickly is expected to be proven, which may provide new ideas for amino acid therapy for some diseases. Lay Abstract: The twenty amino acids making up proteins in animals are classified into three nutritional classes: EAAs, NEAAs and CEAAs. Previous studies show that the amino acid composition of proteins can interact with amino acid availability to influence protein expression levels, independently of the amount of mRNA produced. By analysing the bioinformatic data of protein expression levels in human cells, protein expression was observed to be affected in the way that the more CEAAs present in a protein, the lower its expression, which was particularly evident in cells proliferating quickly. In this project, plasmid constructs were created that express artificial proteins containing almost only one amino acid nutritional class with a V5 epitope at the terminal. These were transfected into A549 cells to test the hypothesis from data analysis in real-life cells that proteins with extreme proportions of CEAAs tend to reduce expression and are most affected by proliferation compared with proteins with other proportions of amino acid class. The V5 tag is an epitope that can be detected by certain antibodies on Western blot or in cells. Through measuring the amount of certain A549 cell protein synthesis in different treatment groups, the results show that proteins with extreme proportions of CEAAs tend to reduce in expression but are not the most affected by proliferation. However, proteins of what amino acid composition ratio are most affected by proliferation and the specific mechanism behind the effect need further study.
A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model
Authors: Sugimoto Mitsuru , Takagi Tadayuki , Suzuki Tomohiro , Shimizu Hiroshi , Shibukawa Goro , Nakajima Yuki , Takeda Yutaro , Noguchi Yuki , Kobayashi Reiko , Imamura Hidemichi , Asama Hiroyuki , Konno Naoki , Waragai Yuichi , Akatsuka Hidenobu , Suzuki Rei , Hikichi Takuto , Ohira Hiromasa 
Published: September 2024

Background:Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) is a severe and deadly adverse event following ERCP. The ideal method for predicting PEP risk before ERCP has yet to be identified. We aimed to establish a simple PEP risk score model (SuPER model: Support for PEP Reduction) that can be applied before ERCP.Methods:This multicenter study enrolled 2074 patients who underwent ERCP. Among them, 1037 patients each were randomly assigned to the development and validation cohorts. In the development cohort, the risk score model for predicting PEP was established via logistic regression analysis. In the validation cohort, the performance of the model was assessed.Results:In the development cohort, five PEP risk factors that could be identified before ERCP were extracted and assigned weights according to their respective regression coefficients: –2 points for pancreatic calcification, 1 point for female sex, and 2 points for intraductal papillary mucinous neoplasm, a native papilla of Vater, or the pancreatic duct procedures (treated as ‘planned pancreatic duct procedures’ for calculating the score before ERCP). The PEP occurrence rate was 0% among low-risk patients (≤0 points), 5.5% among moderate-risk patients (1–3 points), and 20.2% among high-risk patients (4–7 points). In the validation cohort, the C statistic of the risk score model was 0.71 (95% CI 0.64–0.78), which was considered acceptable. The PEP risk classification (low, moderate, and high) was a significant predictive factor for PEP that was independent of intraprocedural PEP risk factors (precut sphincterotomy and inadvertent pancreatic duct cannulation) (OR 4.2, 95% CI 2.8–6.3; p<0.01).Conclusions:The PEP risk score allows an estimation of the risk of PEP prior to ERCP, regardless of whether the patient has undergone pancreatic duct procedures. This simple risk model, consisting of only five items, may aid in predicting and explaining the risk of PEP before ERCP and in preventing PEP by allowing selection of the appropriate expert endoscopist and useful PEP prophylaxes.Funding:No external funding was received for this work.
In silico directed evolution of Anabas testudineus AtMP1 antimicrobial peptide to improve in vitro anticancer activity
Authors: Fazry Shazrul , Najm Ahmed Abdulkareem , Mahdi Ibrahim Mahmood , Ang Arnold , Lee LiTing , Loh Choy-Theng , Syed Alwi Sharifah Sakinah , Li Fang , Law Douglas 
Published: September 2024

Various studies have demonstrated that directed evolution is a powerful tool in enhancing protein properties. In this study, directed evolution was used to enhance the efficacy of synthesised Anabas testudineus AtMP1 antimicrobial peptides (AMPs) in inhibiting the proliferation of cancer cells. The modification of antimicrobial peptides (AMPs) and prediction of peptide properties using bioinformatic tools were carried out using four databases, including ADP3, CAMP-R3, AMPfun, and ANTICP. One modified antimicrobial peptide (AMP), ATMP6 (THPPTTTTTTTTTTTTTAAPARTT), was chosen based on its projected potent anticancer effect, taking into account factors such as amino acid length, net charge, anticancer activity score, and hydrophobicity. The selected AMPs were subjected to study in deep-learning databases, namely ToxIBTL and ToxinPred2, to predict their toxicity. Furthermore, the allergic properties of these antimicrobial peptides (AMPs) were verified by utilising AllerTOP and AllergenFP. Based on the results obtained from the database study, it was projected that antimicrobial peptides (AMPs) demonstrate a lack of toxicity towards human cells that is indicative of the broader population. After 48 hours of incubation, the IC50 values of ATMP6 against the HS27 and MDA-MB-231 cell lines were found to be 48.03 ± 0.013 µg/ml and 7.52 ± 0.027 µg/ml, respectively. The IC50 values of the original peptide ATMP1 against the MDA-MB-231 and HS27 cell lines were determined to be 59.6 ± 0.14 µg/ml and 8.25 ± 0.14 µg/ml, respectively, when compared. Furthermore, the results indicated that the injection of ATMP6 induced apoptosis in the MDA-MB-231 cell lines. The present investigation has revealed new opportunities for advancing novel targeted peptide therapeutics to tackle cancer.
Diverse Reactivity in a Rhodium(III)‐Catalyzed Vinylic sp2 C–H Bond Functionalization: Synthesis of Fused Polycyclic Heteroarenes or Conjugated Dienes
Authors: Li Shuai‐Shuai , Xia Ying‐Qi , Liu Chen‐Fei , Zhang Guo‐Tai , Su Fu , Zhang Xiao‐Mei , Dong Lin 
Published: November 2016

AbstractAn efficient rhodium(III)‐catalyzed vinylic sp2 C–H bond activation of 7‐azaindoles with alkynes is reported, leading to the controlled synthesis of stereodefined diene and fused polycyclic heteroarene products. The novel strategy for the synthesis of diverse coupling products was controlled by the reaction conditions and the substitutions on the vinyl group.magnified image
Copper‐Mediated Tandem C(sp2)–H Sulfenylation and Annulation of Arenes with 2‐Mercaptoimidazoles: Regio‐ and Site‐selective Access to Polycyclic Fused Imidazo[2,1‐b][1,3]thiazinones
Authors: Liu Jidan , Xue Zixi , Zeng Zhizhao , Chen Yi‐xin , Chen Guoshu 
Published: November 2016

AbstractAn efficient copper‐mediated tandem C(sp2)–H sulfenylation and annulation of arenes with 2‐mercaptoimidazoles to provide polycyclic fused imidazo[2,1‐b][1,3]thiazinones has been developed. This tandem reaction is likely initiated by C(sp2)–H thiolation of benzamide with 2‐mercaptoimidazole followed by intramolecular nucleophilic substitution of the amide carbonyl group. A notable feature of this reaction is that it can afford rather complex products in a single synthesis step from easily accessible starting materials using amide‐oxazoline as a removable bidentate directing group. A variety of benzamides and 2‐mercaptoimidazoles bearing different substituents are compatible with this transformation.magnified image
Synthesis of 3‐Benzazepines by Metal‐Free Oxidative C–H Bond Functionalization–Ring Expansion Tandem Reaction
Authors: Gini Andrea , Bamberger Julia , Luis‐Barrera Javier , Zurro Mercedes , Mas‐Ballesté Rubén , Alemán José , Mancheño Olga García 
Published: November 2016

AbstractA metal‐free synthesis of biologically important benzazepines is achieved through a single synthetic operation involving an oxidative C–H bond functionalization and ring expansion with diazomethanes as key reagent. This represents a new, strong methodology for the straightforward construction of the seven‐ring N‐heterocyclic structures under mild conditions using a 2,2,6,6‐tetramethylpiperidine 1‐oxyl (TEMPO) oxoammonium salt as oxidant. Moderate to good yields are achieved from simple, readily available tetrahydroisoquinolines, and this methodology has been further successfully applied for the synthesis of the 3‐benzazepine drug Lorcaserin. A possible mechanistic pathway for the ring expansion step, comprising the extrusion of nitrogen in a concerted asynchronic process, is proposed based on both mechanistic proof and density function theory (DFT) calculations.magnified image
Large‐Area, Freestanding MOF Films of Planar, Curvilinear, or Micropatterned Topographies
Authors: Yoon Seok Min , Park Jun Heuk , Grzybowski Bartosz A. 
Published: November 2016

AbstractFreestanding MOF films up to six‐inches across and replicating various surface (micro)patterns are prepared via a templated growth method. When grown on copper supports, these films have preferred orientation of the constituent crystallites, translating into markedly different wetting properties of the film's two surfaces (water‐pinning vs. water repellant). In addition, the films exhibit differential sorption of various organic solvents, can recover oil spills from seawater, and can also act as active layers of chemical sensors.
Das Tris(pentafluorethyl)silanid‐Anion
Authors: Schwarze Nico , Steinhauer Simon , Neumann Beate , Stammler Hans‐Georg , Hoge Berthold 
Published: November 2016

AbstractTris(pentafluorethyl)silan, das durch die simple Umsetzung von Si(C2F5)3X (X=Cl, Br) mit Bu3SnH zugänglich ist, wird in Hydrosilylierungsreaktionen eingesetzt. In Gegenwart eines Palladiumkatalysators liefert die Hydrosilylierung von Phenylacetylen mit Si(C2F5)3H das α‐Additionsprodukt, wohingegen die Hydrosilylierung von Trimethylsilylacetylen zur Bildung des β‐trans‐Produktes führt. Sterisch anspruchsvolle Basen wie Lithiumdiisopropylamid ermöglichen die Deprotonierung des Tris(pentafluorethyl)silans bei tiefen Temperaturen, was die Bildung des entsprechenden Silanid‐Anions zur Folge hat. Die Zugabe von Kronenethern oder Kryptanden zu dieser hochreaktiven Spezies erlaubt die Isolierung und Charakterisierung des salzartigen Tris(pentafluorethyl)silanids bei Raumtemperatur.
Biomimicry Promotes the Efficiency of a 10‐Step Sequential Enzymatic Reaction on Nanoparticles, Converting Glucose to Lactate
Authors: Mukai Chinatsu , Gao Lizeng , Nelson Jacquelyn L. , Lata James P. , Cohen Roy , Wu Lauren , Hinchman Meleana M. , Bergkvist Magnus , Sherwood Robert W. , Zhang Sheng , Travis Alexander J. 
Published: November 2016

AbstractFor nanobiotechnology to achieve its potential, complex organic–inorganic systems must grow to utilize the sequential functions of multiple biological components. Critical challenges exist: immobilizing enzymes can block substrate‐binding sites or prohibit conformational changes, substrate composition can interfere with activity, and multistep reactions risk diffusion of intermediates. As a result, the most complex tethered reaction reported involves only 3 enzymes. Inspired by the oriented immobilization of glycolytic enzymes on the fibrous sheath of mammalian sperm, here we show a complex reaction of 10 enzymes tethered to nanoparticles. Although individual enzyme efficiency was higher in solution, the efficacy of the 10‐step pathway measured by conversion of glucose to lactate was significantly higher when tethered. To our knowledge, this is the most complex organic–inorganic system described, and it shows that tethered, multi‐step biological pathways can be reconstituted in hybrid systems to carry out functions such as energy production or delivery of molecular cargo.