bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-sectional associations between dietary intake and carotid intima media thickness in type 2 diabetes: baseline data from a randomised trial
Authors: Chiavaroli Laura , Mirrahimi Arash , Ireland Christopher , Mitchell Sandra , Sahye-Pudaruth Sandhya , Coveney Judy , Olowoyeye Omodele , Patel Darshna , de Souza Russell J , Augustin Livia S A , Bashyam Balachandran , Pichika Sathish Chandra , Blanco Mejia Sonia , Nishi Stephanie K , Leiter Lawrence A , Josse Robert G , McKeown-Eyssen Gail E , Moody Alan R , Kendall Cyril W C , Sievenpiper John L , Jenkins David J A 
Published: March 2017

ObjectiveTo assess associations between dietary intake and carotid intima media thickness (CIMT) by carotid ultrasound (CUS), a surrogate marker of cardiovascular disease (CVD) risk, in those with type 2 diabetes.DesignCross-sectional analysis of baseline data from 325 participants from three randomised controlled trials collected in the same way.SettingRisk Factor Modification Centre, St. Michael's Hospital, Toronto, Canada.Participants325 participants with type 2 diabetes, taking oral antidiabetic agents, with an HbA1c between 6.5% and 8.0% at screening, without a recent cardiovascular event.Main outcome measuresCIMT by CUS and associations with dietary intake from 7-day food records, as well as anthropometric measures and fasting serum samples.ResultsCIMT was significantly inversely associated with dietary pulse intake (β=−0.019, p=0.009), available carbohydrate (β=−0.004, p=0.008), glycaemic load (β=−0.001, p=0.007) and starch (β=−0.126, p=0.010), and directly associated with total (β=0.004, p=0.028) and saturated (β=0.012, p=0.006) fat intake in multivariate regression models adjusted for age, smoking, previous CVD event, blood pressure medication, antidiabetic medication and ultrasonographer.ConclusionsLower CIMT was significantly associated with greater consumption of dietary pulses and carbohydrates and lower total and saturated fat intake, suggesting a potential role for diet in CVD risk management in type 2 diabetes. Randomised controlled trials are anticipated to explore these associations further.Trial registration numberNCT01063374.
Engagement and learning in simulation: recommendations of the Simnovate Engaged Learning Domain Group
Authors: Choi Wayne , Dyens Ollivier , Chan Teresa , Schijven Mariles , Lajoie Susanne , Mancini Mary E , Dev Parvati , Fellander-Tsai Li , Ferland Mathieu , Kato Pamela , Lau James , Montonaro Michael , Pineau Joelle , Aggarwal Rajesh 
Published: March 2017

BackgroundHealth professions education (HPE) is based on deliberate learning activities and clinical immersion to achieve clinical competence. Simulation is a tool that helps bridge the knowledge-to-action gap through deliberate learning. This paper considers how to optimally engage learners in simulation activities as part of HPE.MethodsThe Simnovate Engaged Learning Domain Group undertook 3 teleconferences to survey the current concepts regarding pervasive learning. Specific attention was paid to engagement in the learning process, with respect to fidelity, realism and emotions, and the use of narratives in HPE simulation.ResultsThis paper found that while many types of simulation exist, the current ways to categorise the types of simulation do not sufficiently describe what a particular simulation will entail. This paper introduces a novel framework to describe simulation by deconstructing a simulation activity into 3 core characteristics (scope, modality and environment). Then, the paper discusses how engagement is at the heart of the learning process, but remained an understudied phenomenon with respect to HPE simulation. Building on the first part, a conceptual framework for engaged learning in HPE simulation was derived, with potential use across all HPE methods.DiscussionThe framework considers how the 3 characteristics of simulation interplay with the dimensions of fidelity (physical, conceptual and emotional), and how these can be conveyed by and articulated through beauty (as a proxy for efficiency) as coexisting factors to drive learner engagement. This framework leads to the translation of deliberately taught knowledge, skills and attitudes into clinical competence and subsequent performance.
Evaluating the role of simulation in healthcare innovation: recommendations of the Simnovate Medical Technologies Domain Group
Authors: Madani Amin , Gallix Benoit , Pugh Carla M , Azagury Dan , Bradley Paul , Fowler Dennis , Hannaford Blake , Macdonald Sumaira , Miyasaka Kiyoyuki , Nuño Natalia , Szold Amir , Verter Vedat , Aggarwal Rajesh 
Published: March 2017

BackgroundInnovation in healthcare is the practical application of new concepts, ideas, processes or technologies into clinical practice. Despite its necessity and potential to improve care in measurable ways, there are several issues related to patient safety, high costs, high failure rates and limited adoption by end-users. This mixed-method study aims to explore the role of simulation as a potential testbed for diminishing the risks, pitfalls and resources associated with development and implementation of medical innovations.MethodsSubject-matter experts consisting of physicians, engineers, scientists and industry leaders participated in four semistructured teleconferences each lasting up to 2 hours each. Verbal data were transcribed verbatim, coded and categorised according to themes using grounded theory, and subsequently synthesised into a conceptual framework. Panelists were then invited to complete an online survey, ranking the (1) current use and (2) potential effectiveness of simulation-based technologies and techniques for evaluating and facilitating the product life cycle pathway. This was performed for each theme of the previously generated conceptual framework using a Likert scale of 1 (no effectiveness) to 9 (highest possible effectiveness) and then segregated according to various forms of simulation.ResultsOver 100 hours of data were collected and analysed. After 7 rounds of inductive data analysis, a conceptual framework of the product life cycle was developed. This framework helped to define and characterise the product development pathway. Agreement between reviewers for inclusion of items after the final round of analysis was 100%. A total of 7 themes were synthesised and categorised into 3 phases of the pathway: ‘design and development’, ‘implementation and value creation’ and ‘product launch’. Strong discrepancies were identified between the current and potential roles of simulation in each phase. Simulation was felt to have the strongest potential role for early prototyping, testing for safety and product quality and testing for product effectiveness and ergonomics.ConclusionsSimulation has great potential to fulfil several unmet needs in healthcare innovation. This framework can be used to help guide innovators and channel resources appropriately. The ultimate goal is a structured, well-defined process that will result in a product development outcome that has the greatest potential to succeed.
Defending strong tobacco packaging and labelling regulations in Uruguay: transnational tobacco control network versus Philip Morris International
Authors: Crosbie Eric , Sosa Particia , Glantz Stanton A 
Published: March 2017

ObjectiveDescribe the process of enacting and defending strong tobacco packaging and labelling regulations in Uruguay amid Philip Morris International’s (PMI) legal threats and challenges.MethodsTriangulated government legislation, news sources and interviews with policy-makers and health advocates in Uruguay.ResultsIn 2008 and 2009, the Uruguayan government enacted at the time the world’s largest pictorial health warning labels (80% of front and back of package) and prohibited different packaging or presentations for cigarettes sold under a given brand. PMI threatened to sue Uruguay in international courts if these policies were implemented. The Vazquez administration maintained the regulations, but a week prior to President Vazquez’s successor, President Mujica, took office on 1 March 2010 PMI announced its intention to file an investment arbitration dispute against Uruguay in the International Centre for the Settlement of Investment Disputes. Initially, the Mujica administration announced it would weaken the regulations to avoid litigation. In response, local public health groups in Uruguay enlisted former President Vazquez and international health groups and served as brokers to develop a collaboration with the Mujica administration to defend the regulations. This united front between the Uruguayan government and the transnational tobacco control network paid off when Uruguay defeated PMI’s investment dispute in July 2016.ConclusionTo replicate Uruguay’s success, other countries need to recognise that strong political support, an actively engaged local civil society and financial and technical support are important factors in overcoming tobacco industry’s legal threats to defend strong public health regulations.
Methods and resources for computing semantic relatedness
Authors: Feng Yue , Bagheri Ebrahim 
Published: March 2017

Semantic relatedness (SR) is defined as a measurement that quantitatively identifies some form of lexical or functional association between two words or concepts based on the contextual or semantic similarity of those two words regardless of their syntactical differences. Section 1 of the entry outlines the working definition of SR and its applications and challenges. Section 2 identifies the knowledge resources that are popular among SR methods. Section 3 reviews the primary measurements used to calculate SR. Section 4 reviews the evaluation methodology which includes gold standard dataset and methods. Finally, Sec. 5 introduces further reading. In order to develop appropriate SR methods, there are three key aspects that need to be examined: (1) the knowledge resources that are used as the source for extracting SR; (2) the methods that are used to quantify SR based on the adopted knowledge resource; and (3) the datasets and methods that are used for evaluating SR techniques. The first aspect involves the selection of knowledge bases such as WordNet or Wikipedia. Each knowledge base has its merits and downsides which can directly affect the accuracy and the coverage of the SR method. The second aspect relies on different methods for utilizing the beforehand selected knowledge resources, for example, methods that depend on the path between two words, or a vector representation of the word. As for the third aspect, the evaluation for SR methods consists of two aspects, namely (1) the datasets that are used and (2) the various performance measurement methods. SR measures are increasingly applied in information retrieval to provide semantics between query and documents to reveal relatedness between non-syntactically-related content. Researchers have already applied many different information and knowledge sources in order to compute SR between two words. Empirical research has already shown that results of many of these SR techniques have reasonable correlation with human subjects interpretation of relatedness between two words.
Certifying a file system using crash hoare logic
Authors: Chajed Tej , Chen Haogang , Chlipala Adam , Kaashoek M. Frans , Zeldovich Nickolai , Ziegler Daniel 
Published: March 2017

FSCQ is the first file system with a machine-checkable proof that its implementation meets a specification, even in the presence of fail-stop crashes. FSCQ provably avoids bugs that have plagued previous file systems, such as performing disk writes without sufficient barriers or forgetting to zero out directory blocks. If a crash happens at an inopportune time, these bugs can lead to data loss. FSCQ's theorems prove that, under any sequence of crashes followed by reboots, FSCQ will recover its state correctly without losing data.
To state FSCQ's theorems, this paper introduces the Crash Hoare logic (CHL), which extends traditional Hoare logic with a crash condition, a recovery procedure, and logical address spaces for specifying disk states at different abstraction levels. CHL also reduces the proof effort for developers through proof automation. Using CHL, we developed, specified, and proved the correctness of the FSCQ file system. Although FSCQ's design is relatively simple, experiments with FSCQ as a user-level file system show that it is sufficient to run Unix applications with usable performance. FSCQ's specifications and proofs required significantly more work than the implementation, but the work was manageable even for a small team of a few researchers.<!-- END_PAGE_1 -->
Nutrient sensing by absorptive and secretory progenies of small intestinal stem cells
Authors: Kishida Kunihiro , Pearce Sarah C. , Yu Shiyan , Gao Nan , Ferraris Ronaldo P. 
Published: March 2017

Nutrient sensing triggers responses by the gut-brain axis modulating hormone release, feeding behavior and metabolism that become dysregulated in metabolic syndrome and some cancers. Except for absorptive enterocytes and secretory enteroendocrine cells, the ability of many intestinal cell types to sense nutrients is still unknown; hence we hypothesized that progenitor stem cells (intestinal stem cells, ISC) possess nutrient sensing ability inherited by progenies during differentiation. We directed via modulators of Wnt and Notch signaling differentiation of precursor mouse intestinal crypts into specialized organoids each containing ISC, enterocyte, goblet, or Paneth cells at relative proportions much higher than in situ as determined by mRNA expression and immunocytochemistry of cell type biomarkers. We identified nutrient sensing cell type(s) by increased expression of fructolytic genes in response to a fructose challenge. Organoids comprised primarily of enterocytes, Paneth, or goblet, but not ISC, cells responded specifically to fructose without affecting nonfructolytic genes. Sensing was independent of Wnt and Notch modulators and of glucose concentrations in the medium but required fructose absorption and metabolism. More mature enterocyte- and goblet-enriched organoids exhibited stronger fructose responses. Remarkably, enterocyte organoids, upon forced dedifferentiation to reacquire ISC characteristics, exhibited a markedly extended lifespan and retained fructose sensing ability, mimicking responses of some dedifferentiated cancer cells. Using an innovative approach, we discovered that nutrient sensing is likely repressed in progenitor ISCs then irreversibly derepressed during specification into sensing-competent absorptive or secretory lineages, the surprising capacity of Paneth and goblet cells to detect fructose, and the important role of differentiation in modulating nutrient sensing.NEW & NOTEWORTHY Small intestinal stem cells differentiate into several cell types transiently populating the villi. We used specialized organoid cultures each comprised of a single cell type to demonstrate that 1) differentiation seems required for nutrient sensing, 2) secretory goblet and Paneth cells along with enterocytes sense fructose, suggesting that sensing is acquired after differentiation is triggered but before divergence between absorptive and secretory lineages, and 3) forcibly dedifferentiated enterocytes exhibit fructose sensing and lifespan extension.
Increased hypoxia-inducible factor-1α in striated muscle of tumor-bearing mice
Authors: Devine Raymond D. , Bicer Sabahattin , Reiser Peter J. , Wold Loren E. 
Published: March 2017

Cancer cachexia is a progressive wasting disease resulting in significant effects on the quality of life and high mortality. Most studies on cancer cachexia have focused on skeletal muscle; however, the heart is now recognized as a major site of cachexia-related effects. To elucidate possible mechanisms, a proteomic study was performed on the left ventricles of colon-26 (C26) adenocarcinoma tumor-bearing mice. The results revealed several changes in proteins involved in metabolism. An integrated pathway analysis of the results revealed a common mediator in hypoxia-inducible factor-1α (HIF-1α). Work by other laboratories has shown that extensive metabolic restructuring in the C26 mouse model causes changes in gene expression that may be affected directly by HIF-1α, such as glucose metabolic genes. M-mode echocardiography showed progressive decline in heart function by day 19, exhibited by significantly decreased ejection fraction and fractional shortening, along with posterior wall thickness. Using Western blot analysis, we confirmed that HIF-1α is significantly upregulated in the heart, whereas there were no changes in its regulatory proteins, prolyl hydroxylase domain-containing protein 2 (PHD2) and von Hippel-Lindau protein (VHL). PHD2 requires both oxygen and iron as cofactors for the hydroxylation of HIF-1α, marking it for ubiquination via VHL and subsequent destruction by the proteasome complex. We examined venous blood gas values in the tumor-bearing mice and found significantly lower oxygen concentration compared with control animals in the third week after tumor inoculation. We also examined select skeletal muscles to determine whether they are similarly affected. In the diaphragm, extensor digitorum longus, and soleus, we found significantly increased HIF-1α in tumor-bearing mice, indicating a hypoxic response, not only in the heart, but also in skeletal muscle. These results indicate that HIF-1α may contribute, in part, to the metabolic changes that occur during cancer cachexia. NEW & NOTEWORTHY We used proteomics and metadata analysis software to identify contributors to metabolic changes in striated muscle during cancer cachexia. We found increased expression of hypoxia-inducible factor-1α in the heart and skeletal muscle, suggesting a potential target for the therapeutic treatment of cancer cachexia.
Muscle length-dependent contribution of motoneuron Cav1.3 channels to force production in model slow motor unit
Authors: Kim Hojeong 
Published: March 2017

Persistent inward current (PIC)-generating Cav1.3 channels in spinal motoneuron dendrites are thought to be actively recruited during normal behaviors. However, whether and how the activation of PIC channels influences force output of motor unit remains elusive. Here, building a physiologically realistic model of slow motor unit I demonstrated that force production induced by the PIC activation is much smaller for short than lengthened muscles during the regular firing of the motoneuron that transitions from the quiescent state by either a brief current pulse at the soma or a brief synaptic excitation at the dendrites. By contrast, the PIC-induced force potentiation was maximal for short muscles when the motoneuron switched from a stable low-frequency firing state to a stable high-frequency firing state by the current pulse at the soma. Under the synaptic excitation at the dendrites, however, the force could not be potentiated by the transitioning of the motoneuron from a low- to a high-frequency firing state due to the simultaneous onset of PIC at the dendrites and firing at the soma. The strong dependency of the input-output relationship of the motor unit on the neuromodulation and Ia afferent inputs for the PIC channels was further shown under static variations in muscle length. Taken together, these findings suggest that the PIC activation in the motoneuron dendrites may differentially affect the force production of the motor unit, depending not only on the firing state history of the motoneuron and the variation in muscle length but also on the mode of motor activity.NEW & NOTEWORTHY Cav1.3 channels in motoneuron dendrites are actively involved during normal motor activities. To investigate the effects of the activation of motoneuron Cav1.3 channels on force production, a model motor unit was built based on best-available data. The simulation results suggest that force potentiation induced by Cav1.3 channel activation is strongly modulated not only by firing history of the motoneuron but also by length variation of the muscle as well as neuromodulation inputs from the brainstem.
The effects of short work vs. longer work periods within intermittent exercise on V̇o2pkinetics, muscle deoxygenation, and energy system contribution
Authors: McCrudden Michael C. , Keir Daniel A. , Belfry Glen R. 
Published: March 2017

We examined the effects of inserting 3-s recovery periods during high-intensity cycling exercise at 25-s and 10-s intervals on pulmonary oxygen uptake (V̇o2p), muscle deoxygenation [deoxyhemoglobin (HHb)], their associated kinetics (τ), and energy system contributions. Eleven men (24 ± 3 yr) completed two trials of three cycling protocols: an 8-min continuous protocol (CONT) and two 8-min intermittent exercise protocols with work-to-rest periods of 25 s to 3 s (25INT) and 10 s to 3 s (10INT). Each protocol began with a step-transition from a 20-W baseline to a power output (PO) of 60% between lactate threshold and maximal V̇o2p(Δ60). This PO was maintained for 8 min in CONT, whereas 3-s periods of 20-W cycling were inserted every 10 s and 25 s after the transition to Δ60 in 10INT and 25INT, respectively. Breath-by-breath gas exchange measured by mass spectrometry and turbine and vastus lateralis [HHb] measured by near-infrared spectroscopy were recorded throughout. Arterialized-capillary lactate concentration ([Lac−]) was obtained before and 2 min postexercise. The τV̇o2pwas lowest ( P < 0.05) for 10INT (24 ± 4 s) and 25INT (23 ± 5 s) compared with CONT (28 ± 4 s), whereas HHb kinetics did not differ ( P > 0.05) between conditions. Postexercise [Lac−] was lowest ( P < 0.05) for 10INT (7.0 ± 1.7 mM), was higher for 25INT (10.3 ± 1.9 mM), and was greatest in CONT (14.3 ± 3.1 mM). Inserting 3-s recovery periods during heavy-intensity exercise speeded V̇o2pkinetics and reduced overall V̇o2p, suggesting an increased reliance on PCr-derived phosphorylation during the work period of INT compared with an identical PO performed continuously.NEW & NOTEWORTHY We report novel observations on the effects of differing heavy-intensity work durations between 3-s recovery periods on pulmonary oxygen uptake (V̇o2p) kinetics, muscle deoxygenation, and energy system contributions. Relative to continuous exercise, V̇o2pkinetics are faster in intermittent exercise, and increased frequency of 3-s recovery periods improves microvascular O2delivery and reduces V̇o2pand arterialized-capillary lactate concentration. The metabolic burden of identical intensity work is altered when performed intermittently vs. continuously.