bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pelvic retroversion: a compensatory mechanism for lumbar stenosis
Authors: Pourtaheri Sina , Sharma Akshay , Savage Jason , Kalfas Iain , Mroz Thomas E. , Benzel Edward , Steinmetz Michael P. 
Published: June 2017

OBJECTIVEThe flexed posture of the proximal (L1–3) or distal (L4–S1) lumbar spine increases the diameter of the spinal canal and neuroforamina and can relieve symptoms of neurogenic claudication. Distal lumbar flexion can result in pelvic retroversion; therefore, in cases of flexible sagittal imbalance, pelvic retroversion may be compensatory for lumbar stenosis and not solely compensatory for the sagittal imbalance as previously thought. The authors investigate underlying causes for pelvic retroversion in patients with flexible sagittal imbalance.METHODSOne hundred thirty-eight patients with sagittal imbalance who underwent a total of 148 fusion procedures of the thoracolumbar spine were identified from a prospective clinical database. Radiographic parameters were obtained from images preoperatively, intraoperatively, and at 6-month and 2-year follow-up. A cohort of 24 patients with flexible sagittal imbalance was identified and individually matched with a control cohort of 23 patients with fixed deformities. Flexible deformities were defined as a 10° change in lumbar lordosis between weight-bearing and non–weight-bearing images. Pelvic retroversion was quantified as the ratio of pelvic tilt (PT) to pelvic incidence (PI).RESULTSThe average difference between lumbar lordosis on supine MR images and standing radiographs was 15° in the flexible cohort. Sixty-eight percent of the patients in the flexible cohort were diagnosed preoperatively with lumbar stenosis compared with only 22% in the fixed sagittal imbalance cohort (p = 0.0032). There was no difference between the flexible and fixed cohorts with regard to C-2 sagittal vertical axis (SVA) (p = 0.95) or C-7 SVA (p = 0.43). When assessing for postural compensation by pelvic retroversion in the stenotic patients and nonstenotic patients, the PT/PI ratio was found to be significantly greater in the patients with stenosis (p = 0.019).CONCLUSIONSFor flexible sagittal imbalance, preoperative attention should be given to the root cause of the sagittal misalignment, which could be compensation for lumbar stenosis. Pelvic retroversion can be compensatory for both the lumbar stenosis as well as for sagittal imbalance.
Neuropsychological Symptoms in Sporadic Creutzfeldt-Jakob Disease Patients in Germany
Authors: Krasnianski Anna , Bohling Geeske T. , Heinemann Uta , Varges Daniela , Meissner Bettina , Schulz-Schaeffer Walter J. , Reif Andreas , Zerr Inga 
Published: June 2017

Background: The polymorphism at codon 129 of the prion protein gene (PRNP) and the PrPSc types 1 and 2 belong to a molecular classification of sporadic Creutzfeldt-Jakob disease (sCJD) that correlates well with the clinical and neuropathological phenotype of sCJD. Objective: The aim of the study was to perform the first detailed evaluation of neuropsychological deficits in a large group of definite sCJD patients with known molecular subtype. Methods: We analyzed neuropsychological symptoms in a cohort of 248 sCJD patients with known M129 V polymorphism of PRNP and prion protein type. Results: Neuropsychological symptoms were very frequent in our patients (96%) and occurred as early as in the first third of the disease course. Besides amnesia and impaired attention (89% each), frontal lobe syndrome (75%), aphasia (63%), and apraxia (57%) were the most common neuropsychological deficits. There was no statistically significant difference with regard to frequency of neuropsychological symptoms between the subtypes. In MV2 and VV2 patients, the onset of neuropsychological symptoms was significantly later than in all other subtypes. Conclusion: We provide the first detailed analysis of neuropsychological symptoms in a large group of sCJD patients with known M129 V genotype and prion protein type. We suggest that the rate of progression of neuropsychological symptoms is subtype-specific. These data may improve the diagnosis in atypical sCJD subtypes.
Update on the application of optic nerve sheath fenestration
Authors: Chen Hui , Zhang Qian , Tan Song , Fu Huazhu , Farris Bradley K. , Yang Zhenglin 
Published: June 2017

Background:With the ongoing development of surgical procedures and instruments, the safety of optic nerve sheath fenestration (ONSF) has been improved. Objective:Through the past three decades, progress has been made in preventing visual loss from chronic optic nerve swelling in idiopathic intracranial hypertension (IIH), secondary intracranial hypertension and local optic nerve diseases. We now review the updated application of ONSF in those diseases. Methods:The application of ONSF in papilledema due to IIH, secondary intracranial hypertension to cerebral venous sinus occlusion, Cryptococcal meningitis, and intracranial mass or tumors is reviewed. Additionally, the potential benefits of ONSF in local optic neuropathy from optic nerve sheath meningioma, optic nerve drusen, traumatic optic neuropathy and optic nerve/sheath biopsy are also described. Results:Although ONSF has little or no effect on intracranial pressure, it is a safe, relative easy and effective surgical procedure to prevent or reverse visual loss in IIH. When other treatment modalities fail to timely protect vision, ONSF can be useful in protecting visual function or delay visual loss in secondary intracranial hypertension. Conclusion:We recommend that ONSF should be considered as a meaningful alternative or an adjunct therapy to reduce or delay the visual morbidity of these diseases, although the use of ONSF for some of them remains controversial.
Effects of intermittent theta burst stimulation on spasticity after spinal cord injury
Authors: Nardone Raffaele , Langthaler Patrick B. , Orioli Andrea , Höller Peter , Höller Yvonne , Frey Vanessa N. , Brigo Francesco , Trinka Eugen 
Published: June 2017

Purpose: Spasticity is a common disorder in patients with spinal cord injury (SCI). The aim of this study was to investigate whether intermittent theta burst stimulation (iTBS), a safe, non-invasive and well-tolerated protocol of excitatory repetitive transcranial magnetic stimulation (rTMS), is effective in modulating spasticity in SCI patients. Methods: In this randomized, double-blind, crossover, sham-controlled study, ten subjects with incomplete cervical or thoracic SCI received 10 days of daily sessions of real or sham iTBS. The H/M amplitude ratio of the Soleus H reflex, the amplitude of the motor evoked potentials (MEPs) at rest and during background contraction, as well as Modified Ashworth Scale (MAS) and the Spinal Cord Injury Assessment Tool for Spasticity (SCAT) were compared before and after the stimulation protocols. Results: Patients receiving real iTBS showed significant increased resting and active MEPs amplitude and a significant reduction of the H/M amplitude ratio. In these patients also the MAS and SCAT scores were significantly reduced after treatment. These changes persisted up to 1 week after the end of the iTBS treatment, and were not observed under the sham-TBS condition. Conclusion: These findings suggest that iTBS may be a promising therapeutic tool for the spasticity in SCI patients.
The role of the dorsal Anterior Cingulate Cortex (dACC) in a cognitive and emotional counting Stroop task: Two cases
Authors: To Wing Ting , De Ridder Dirk , Menovsky Tomas , Hart John , Vanneste Sven 
Published: June 2017

Background: The anterior cingulate cortex (ACC) has been implicated in both cognitive and emotional processing, with cognitive information proposed to be processed through the dorsal/caudal ACC and emotional information through the rostral/ventral ACC. Objective: The objective of this study is to investigate the role of the dorsal anterior cingulate cortex (dACC) in cognitive and emotional processing using a cognitive and emotional counting Stroop task in two patients in whom abnormalities in the dACC were identified and treated. Methods: Two patients performed the cognitive and emotional counting Stroop task before and after treatment to examine whether the dACC has a specific or more general processing function. Results: We observed an overall improvement in the emotional, cognitive, and neutral trials of the counting Stroop task after the intervention, indicating that the dACC is not a subregion of the ACC that only contributes to a specific domain. Conclusion: This study reveals that the dACC is not just a subregion of the ACC that contributes to a specific cognitive function, but is rather part of a salience network that influences general brain functioning, influencing cognitive as well as emotional processing.
Role of Whole-Body Tc 99m MDP Bone Scintigraphy for Evaluating Skeletal Metastasis in Patients with Lung Cancer
Authors: Afrin Rawnak , Haque Fatema Sultana , Biswas Shankar Kumar , Hossain Sanowar , Jahan Mahmood Uz 
Published: June 2017

Lung cancer is the third most common site of origin of metastatic cancer deposits in bone, after breast and prostate. Its metastasis to bone is one of the most aggressive tumors and has a very unfavorable prognosis. This retrospective descriptive study was designed to detect the skeletal metastasis of carcinoma (Ca) lung patient by Tc 99m MDP bone scan. The medical records of all patients attended between January 2015 and July 2015 with a diagnosis of lung cancer were reviewed. Lung cancer in all patients was confirmed pathologically, and patients underwent whole-body bone scan for evaluating skeletal metastasis. Patient with clinical and laboratory evidence of infection, trauma, metabolic disease or arthropathy were not included in the study. Bone scan was done after three hours of intravenous administration of 20mci Tc 99m MDP (methylene diphosphonate) and images were obtained on a gamma camera. The mean age of the patients was Mean ± SD was 55.5 ± 12.5 with range from 31 to 90 years. Out of 47 cases, 36 (76.59%) were diagnosed as positive for skeletal metastasis by bone scan and 11 (23.41%) were negative for bony metastasis. Among 36 positive patients, 28 patients (77.86%) were histopathologically diagnosed as adenocarcinoma, 7 patients (19.44%) had squamous cell carcinoma and only one patient (2,7%) had small cell carcinoma. Bone scan findings were compared by either conventional X-ray/CT scan/MRI /pathologically. In present study, the distribution of lesions in bone scan had recorded. Maximum 47.22 % lesions were found in ribs, 27.77% lesions were in lumbar vertebrae, 19.44% in thoracic vertebrae, 19.44% in joints, 16.66% in long bones (femur and humerus), 11.11% in skull bones, 22.22% in pelvic bones, 5.55% in clavicle and 2.77% in scapula. Tc 99m MDP bone scan plays a pivotal role for detection of skeletal metastasis which is very essential to manage Ca lung patient. As bone scintigraphy is very cost effective in govt. nuclear medicine centre in comparison to other imaging modalities, so it can play a major role in detecting skeletal metastasis in ca lung patients in a developing country like Bangladesh.
Incidence of Negative Appendicectomy: Correlation Between Clinical, Peroperative and Histopathological Findings
Authors: Rahman Mohammad Zillur , Islam Johirul , Hasanuzzaman Md. , Habib Ahsan , Bhattachari Avisak 
Published: June 2017

Appendicitis is one of the most difficult diagnostic problems to confront the emergency physician and it is the most common intra-abdominal condition requiring emergency surgery. The term Negative appendicectomy used for operation done for suspected appendicitis, in which the appendix is found to be normal on histological evaluation. The study aimed to find out the incidence of negative appendicectomy evaluating the correlation between clinical, per-operative and histopathological findings. It was a prospective study of 100 cases clinically diagnosed as acute appendicitis selected over a period of one year (July 2006 to June 2007) from different surgical ward of Mymensingh Medical College Hospital. The study revealed a negative appendicectomy rate of 12%. Moreover, in all cases of acute appendicitis, there was a well established bias towards male patients and young male patients constituted the majority of the cases. But the rate of negative appendicectomy found to be higher in female patients, which is 15.9% as compared to only 8.92% male patients. In addition, among female patients differential diagnostic difficulties encountered in females of reproductive age group. More emphasis on technology at the expense of clinical evaluation is certainly responsible for the diminish in accuracy of diagnosis. The diagnosis of acute appendicitis remains essentially clinical, requiring a mixture of observation, clinical acumen and accurate use of diagnostic tools. A correct diagnosis is certainly important than a rapid diagnosis.
Fanconi Anaemia  A Rare Case Report
Authors: Aziz Md Abdul , Chowdhury Mesba Uddin , Khan Rafiquzzaman , Shah Md Salauddin , Islam Shafiqul 
Published: June 2017

Fanconi anaemia is a rare and most common form of inherited aplastic anaemia. It is mostly autosmal (except one x link) recessive disorder characterized by diverse congenital malformations, progressive pancytopenia, and predisposition to both haematological malignancy and solid tumours. Congenital malformation varies from patient to patient and may affect the skeletal system as well as organ systems. Highly variable phenotypic presentation with clinical menifestations makes difficult for diagnosis in some cases. Chromosomal breakage study induce by Mitomycin-C (MMC)/Diepoxybutane(DEB) provide a unique cellular marker for the diagnosis.The incidence of FA is approximately 1 to 5 per million. In Bangladesh, so far no study or even any case was reported. In this case report, a two years nine months old male child presented with generalized weakness , recurrent episodes of fever and physical deformities. It was found him short stature, microcephaly, trianguler face,generalized hyperpigmentation with café au lait spots,absent both thumbs with flexor deformity of both wrists. Peripheral smear found bicytopenia, bone marrow aspiration and biopsy showed hypoplastic marrow mildly elevated LDH, X-ray and USG showed bone and organ agenesis and chromosomal breakage study is also positive.
MULTIGRID METHOD FOR THE SOLUTION OF COMBINED EFFECT OF VISCOSITY VARIATION AND SURFACE ROUGHNESS ON THE SQUEEZE FILM LUBRICATION OF JOURNAL BEARINGS
Authors: Awati Vishwanath B. , Kengangutti Ashwini , N. Mahesh Kumar 
Published: June 2017

The paper presents, the multigrid method for the solution of combined effect of surface roughness and viscosity variation on the squeeze film lubrication of a short journal bearing operating with micropolar fluid. The modified Reynolds equation which incorporates the variation of viscosity in micropolar fluid is analysed using Multigrid method. The governing modified Reynolds equation is solved numerically for the fluid film pressure and bearing characteristics viz. load carrying capacity and squeeze time. The analysis of the results predicts that, the viscosity variation factor decreases the load carrying capacity and squeeze film time, resulting into a longer bearing life. The results are compared with the corresponding analytical solutions.
ANALYSIS OF PERFORMANCE AND EMISSION CHARACTERISTICS OF A DIESEL ENGINE FUELLED WITH BIODIESEL
Authors: Raman R. Sundara , Narayanan G. Sankara , Manoharan N. , Sendilvelan S. 
Published: June 2017

The rapid depletion in world petroleum reserves and uncertainty in petroleum supply due to political and economical reasons along with the sharp escalation in the petroleum prices have simulated the search for alternatives to petroleum based fuels especially diesel and gasoline. Moreover, bulks of petroleum fuels are being consumed by agriculture and transport sector for which diesel engine happens to be the prime mover. Though there are wide varieties of alternative fuels available the research has not yet provided the right renewable fuel to replace diesel. Vegetable oil due to their properties being close to diesel fuel may be a promising alternative for diesel engines. Due to their high viscosity, they cannot be directly used in a diesel engine. Transesterification is one method by which viscosity could be drastically reduced and the fuel could be adopted for use in diesel engine. Present investigation focuses on use of Rice Bran Oil in Diesel engine. Performance and exhaust emission characteristics of the engine have been evaluated. Esterified Rice Bran Oil has exhibited performance very close to that of diesel fuel. In the present work it is observed that, the NOX and unburned hydrocarbon emission decreases and carbon monoxide, particulate emission and smoke intensity increases with the use of biodiesel in diesel engine. When compared to non-esterified Rice Bran Oil, esterified Rice Bran Oil emits less smoke and therefore be regarded as an environment friendly fuel.
INVESTIGATION ON THE PERFORMANCE OF FLAXSEED BIODIESEL BLENDS WITH TIO2 COATED PISTON ON A FOUR STROKE DI DIESEL ENGINE
Authors: Reddy R. Bhaskar , Reddy S. Sunilkumar 
Published: June 2017

Diesel engines are being used extensively for fuel economy but due to gradual depletion of Petroleum resources and increase in exhaust emissions, there is an urgent need for suitable alternative fuels for the diesel engines. As our country is an agricultural country, if the alternate fuels are produced by our farmers it will be beneficial for the country and the farmers also. In recent studies, researchers studied various vegetable oils like canola oil, alovera oil, soya been oil, flaxseed oil and hone oil etc. Out of all flaxseed oil play an important role as an alternative fuel. But the properties of flaxseed oil are not suitable for the usage in the existing diesel engines without blending with diesel fuel. The performance of the engine depends on the combustion phenomenon and it further depends on the amount of heat retained in the combustion chamber. Hence the present work is planned accordingly to develop an insulated engine by coating the piston with TIO2material. So that more amount of heat will be retained in the combustion chamber which aids the combustion. Further the performance of flaxseedbiodiesel blend namely B10, B20, B30 and B40 are tested and the results are mentioned accordingly.
Formation of Complex Molecules in Prestellar Cores: A Multilayer Approach
Authors: Vasyunin A. I. , Caselli P. , Dulieu F. , Jiménez-Serra I. 
Published: June 2017

Abstract
We present the results of chemical modeling of complex organic molecules (COMs) under conditions typical for prestellar cores. We utilize an advanced gas-grain astrochemical model with updated gas-phase chemistry, with a multilayer approach to ice-surface chemistry and an up-to-date treatment of reactive desorption (RD) based on recent experiments of Minissale et al. With the chemical model, radial profiles of molecules, including COMs, are calculated for the case of the prototypical prestellar core L1544 at the timescales when the modeled depletion factor of CO becomes equal to that observed. We find that COMs can be formed efficiently in L1544 up to the fractional abundances of 10(−10) wrt. total hydrogen nuclei. Abundances of many COMs such as CH3OCH3, HCOOCH3, and others peak at similar radial distances of 2000–4000 au. Gas-phase abundances of COMs depend on the efficiency of RD, which in turn depends on the composition of the outer monolayers of icy mantles. In prestellar cores, the outer monolayers of mantles likely include large fractions of CO and its hydrogenation products, which may increase the efficiency of RD according to Minissale et al., and makes the formation of COMs efficient under conditions typical for prestellar cores, though this assumption is yet to be confirmed experimentally. The hydroxyl radical (OH) appears to play an important role in gas-phase chemistry of COMs, which makes it deserving of further detailed studies.
Search for Gamma-Ray Bursts with the ARGO-YBJ Detector in Shower Mode
Authors: Bartoli B. , Bernardini P. , Bi X. J. , Cao Z. , Catalanotti S. , Chen S. Z. , Chen T. L. , Cui S. W. , Dai B. Z. , D’Amone A. , Danzengluobu  , Mitri I. De , Piazzoli B. D’Ettorre , Girolamo T. Di , Sciascio G. Di , Feng C. F. , Feng Zhaoyang , Feng Zhenyong , Gao W. , Gou Q. B. , Guo Y. Q. , He H. H. , Hu Haibing , Hu Hongbo , Iacovacci M. , Iuppa R. , Jia H. Y. , Labaciren  , Li H. J. , Liu C. , Liu J. , Liu M. Y. , Lu H. , Ma L. L. , Ma X. H. , Mancarella G. , Mari S. M. , Marsella G. , Mastroianni S. , Montini P. , Ning C. C. , Perrone L. , Pistilli P. , Salvini P. , Santonico R. , Shen P. R. , Sheng X. D. , Shi F. , Surdo A. , Tan Y. H. , Vallania P. , Vernetto S. , Vigorito C. , Wang H. , Wu C. Y. , Wu H. R. , Xue L. , Yang Q. Y. , Yang X. C. , Yao Z. G. , Yuan A. F. , Zha M. , Zhang H. M. , Zhang L. , Zhang X. Y. , Zhang Y. , Zhao J. , Zhaxiciren  , Zhaxisangzhu  , Zhou X. X. , Zhu F. R. , Zhu Q. Q. ,   (The ARGO-YBJ Collaboration)
Published: June 2017

Abstract
The ARGO-YBJ detector, located at the Yangbajing Cosmic Ray Laboratory (4300 m a. s. l., Tibet, China), was a “full coverage” (central carpet with an active area of ∼93%) air shower array dedicated to gamma-ray astronomy and cosmic-ray studies. The wide field of view (∼2 sr) and high duty cycle (>86%), made ARGO-YBJ suitable to search for short and unexpected gamma-ray emissions like gamma-ray bursts (GRBs). Between 2007 November 6 and 2013 February 7, 156 satellite-triggered GRBs (24 of them with known redshift) occurred within the ARGO-YBJ field of view (zenith angle θ ≤ 45°). A search for possible emission associated with these GRBs has been made in the two energy ranges 10–100 GeV and 10–1000 GeV. No significant excess has been found in time coincidence with the satellite detections nor in a set of different time windows inside the interval of one hour after the bursts. Taking into account the EBL absorption, upper limits to the energy fluence at a 99% confidence level have been evaluated, with values ranging from ∼10−5 erg cm−2 to ∼10−1 erg cm−2. The Fermi-GBM burst GRB 090902B, with a high-energy photon of 33.4 GeV detected by Fermi-LAT, is discussed in detail.
On the Maximum Mass of Accreting Primordial Supermassive Stars
Authors: Woods T. E. , Heger Alexander , Whalen Daniel J. , Haemmerlé Lionel , Klessen Ralf S. 
Published: June 2017

Abstract
Supermassive primordial stars are suspected to be the progenitors of the most massive quasars at z ∼ 6. Previous studies of such stars were either unable to resolve hydrodynamical timescales or considered stars in isolation, not in the extreme accretion flows in which they actually form. Therefore, they could not self-consistently predict their final masses at collapse, or those of the resulting supermassive black hole seeds, but rather invoked comparison to simple polytropic models. Here, we systematically examine the birth, evolution, and collapse of accreting, non-rotating supermassive stars under accretion rates of 0.01–10 M
⊙ yr−1 using the stellar evolution code Kepler. Our approach includes post-Newtonian corrections to the stellar structure and an adaptive nuclear network and can transition to following the hydrodynamic evolution of supermassive stars after they encounter the general relativistic instability. We find that this instability triggers the collapse of the star at masses of 150,000–330,000 M
⊙ for accretion rates of 0.1–10 M
⊙ yr−1, and that the final mass of the star scales roughly logarithmically with the rate. The structure of the star, and thus its stability against collapse, is sensitive to the treatment of convection and the heat content of the outer accreted envelope. Comparison with other codes suggests differences here may lead to small deviations in the evolutionary state of the star as a function of time, that worsen with accretion rate. Since the general relativistic instability leads to the immediate death of these stars, our models place an upper limit on the masses of the first quasars at birth.