bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma
Authors: Powles Thomas , Lackner Mark R. , Oudard Stéphane , Escudier Bernard , Ralph Christy , Brown Janet E. , Hawkins Robert E. , Castellano Daniel , Rini Brian I. , Staehler Michael D. , Ravaud Alain , Lin Wei , O’Keeffe Bridget , Wang Yulei , Lu Shan , Spoerke Jill M. , Huw Ling-Yuh , Byrtek Michelle , Zhu Rui , Ware Joseph A. , Motzer Robert J. 
Published: March 2016

Purpose To the best of our knowledge, this study is the first to compare dual inhibition of PI3K/mammalian target of rapamycin (mTOR) by apitolisib (GDC-0980) against single inhibition of mTORC1 by everolimus in metastatic renal cell carcinoma (mRCC). Patients and Methods Patients with clear-cell mRCC who progressed on or after vascular endothelial growth factor–targeted therapy were randomly assigned to apitolisib 40 mg once per day or to everolimus 10 mg once per day. End points included progression-free survival, safety, overall survival, and objective response rate. Biomarker assessments were conducted. Results Eighty-five patients were randomly assigned. After 67 events, stratified analysis revealed that median progression-free survival was significantly shorter for apitolisib than for everolimus (3.7 v 6.1 months; hazard ratio, 2.12 [95% CI, 1.23 to 3.63; P < .01]); apitolisib was not favored in any stratification subgroup. Median overall survival was not significantly different but trended in favor of everolimus (16.5 v 22.8 months; hazard ratio, 1.77 [95% CI, 0.97 to 3.24; P = .06]). The objective response rate was 7.1% for apitolisib and 11.6% for everolimus. Patients administered apitolisib with a greater incidence of grade 3 to 4 adverse events were more likely to discontinue treatment (31% v 12% for everolimus). No drug-related deaths were observed. Apitolisib in comparison with everolimus was associated with substantially more high-grade hyperglycemia (40% v 9%) and rash (24% v 2%). Apitolisib pharmacokinetics suggested a relationship between exposure, and rash and hyperglycemia. Retrospective biomarker analyses revealed a relationship between VHL mutation status and outcome with everolimus but not with apitolisib. High hypoxia-inducible factor 1α protein expression was associated with better outcome in both arms. Conclusion This study demonstrated that dual PI3K/mTOR inhibition by apitolisib was less effective than was everolimus in mRCC, likely because full blockade of PI3K/mTOR signaling resulted in multiple on-target adverse events. VHL mutation and hypoxia-inducible factor 1α expression may be predictive of an mTOR inhibitor benefit, although prospective validation is required.
Surgical Proficiency Gain and Survival After Esophagectomy for Cancer
Authors: Markar Sheraz R. , Mackenzie Hugh , Lagergren Pernilla , Hanna George B. , Lagergren Jesper 
Published: March 2016

Purpose We aimed to identify the presence and length of esophagectomy proficiency gain curves in terms of short- and long-term mortality for esophageal cancer. Patients and Methods Patients who underwent esophagectomy for esophageal cancer between 1987 and 2010 with follow-up until 2014 were identified from a well-established, population-based, nationwide Swedish cohort study. Proficiency gain curves were created by using risk-adjusted cumulative sum analysis for 30-day, 90-day, 1-year, 3-year, and 5-year all-cause and disease-specific mortality measures. Similarly, the proficiency gain curves for lymph node harvest, resection margin status, and reoperation incidence were assessed as performance-contributing factors to the observed changes in long-term survival. Results Esophagectomies in 1,821 patients with esophageal cancer were conducted by 139 surgeons. The change-point in proficiency gain curve for all-cause 30-day mortality was early, at 15 cases, when mortality decreased from 7.9% to 3.1% (P < .001). Later change-points, which ranged from 35 to 59 cases, were observed for 1-, 3- and 5-year mortality rates, for which all-cause mortality decreased from 34.9% to 27.7% (P = .011), from 47.4% to 41.5% (P = .049), and from 31.4% to 19.1% (P = .009), respectively. Similar change-points were observed in disease-specific mortality at 1 and 3 years. There was a continuous increase in lymph node harvest, which did not plateau. Also, change-points were observed for resection margin with tumor involvement at 17 cases, with a reduction from 20.9% to 15.2% (P = .004), and for reoperation rate at 55 cases, with a reduction from 12.6% to 5.0% (P < .001). Conclusion The gain of proficiency in esophagectomy for cancer is associated with measurable changes in short- and long-term mortality results. These findings indicate a need for structured national training and mentorship programs for esophageal cancer surgery.
Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer
Authors: Halabi Susan , Kelly William Kevin , Ma Hua , Zhou Haojin , Solomon Nicole C. , Fizazi Karim , Tangen Catherine M. , Rosenthal Mark , Petrylak Daniel P. , Hussain Maha , Vogelzang Nicholas J. , Thompson Ian M. , Chi Kim N. , de Bono Johann , Armstrong Andrew J. , Eisenberger Mario A. , Fandi Abderrahim , Li Shaoyi , Araujo John C. , Logothetis Christopher J. , Quinn David I. , Morris Michael J. , Higano Celestia S. , Tannock Ian F. , Small Eric J. 
Published: March 2016

Purpose Reports have suggested that metastatic site is an important predictor of overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC), but these were based on a limited number of patients. We investigate the impact of site of metastases on OS of a substantial sample of men with mCRPC who received docetaxel chemotherapy in nine phase III trials. Patients and Methods Individual patient data from 8,820 men with mCRPC enrolled onto nine phase III trials were combined. Site of metastases was categorized as lymph node (LN) only, bone with or without LN (with no visceral metastases), any lung metastases (but no liver), and any liver metastases. Results Most patients had bone with or without LN metastases (72.8%), followed by visceral disease (20.8%) and LN-only disease (6.4%). Men with liver metastases had the worst median OS (13.5 months). Although men with lung metastases had better median OS (19.4 months) compared with men with liver metastases, they had significantly worse median survival duration than men with nonvisceral bone metastases (21.3 months). Men with LN-only disease had a median OS of 31.6 months. The pooled hazard ratios for death in men with lung metastases compared with men with bone with or without LN metastases and in men with any liver metastases compared with men with lung metastases were 1.14 (95% CI, 1.04 to 1.25; P = .007) and 1.52 (95% CI, 1.35 to 1.73; P < .0001), respectively. Conclusion Specific sites of metastases in men with mCRPC are associated with differential OS, with successive increased lethality for lung and liver metastases compared with bone and nonvisceral involvement. These data may help in treatment decisions, the design of future clinical trials, and understanding the variation in biology of different sites of metastases in men with mCRPC.
The process of rehabilitation of mined forest lands toward degraded forest ecosystem recovery in Kalimantan, Indonesia
Authors: SUDARMADJI TRIYONO , HARTATI WAHJUNI 
Published: March 2016

Sudarmadji T, Hartati W. 2016. The process of rehabilitation of mined forest lands toward degraded forest ecosystemÂ recovery in Kalimantan, Indonesia. Biodiversitas 17: 185-191. An overview of mined forest lands at East and Central KalimantanÂ Indonesia was conducted to determine most important influencing factors supporting degraded forest ecosystem recovery. Consecutivestages of rehabilitation processes consist of reclamation-backfilling, re-contouring, re-shaping, topsoils spreading, and revegetationland preparation, planting, maintenance covering minimum topsoils spreading, soil acidity, plant hole size, soil improvement application (dolomite, organic-inorganic fertilizers),Â vegetation plantingÂ vegetation planting (plant species selection-quality and site matching-verified plantmaterial sources, hardening-off, planting techniques), and land management implementation. The potential degraded forest ecosystem recovery was shown by cover crops and fast growing species plant and undergrowths, survive primary species, decreasing surface runoff/overlandÂ flowsÂ followingÂ increasingÂ soilÂ infiltrationÂ capacities,Â decreasingÂ soilÂ erosionÂ rateÂ andÂ itâ€™sÂ erosionÂ hazard,Â andÂ anÂ improvedÂ environments as habitat for invading wildlifes. The general characteristics of potential degraded forest ecosystem recovery after rehabilitation processes are: spread soil materials thickness > 70 cm, bulk density + 1,2 g.ml-1, soil acidity > 5,5, macro nutrients (N, P, K, Ca, Mg)-low to moderate, decreasing overland water flow following increasing soil infiltration capacity-moderate to high, decreasing soil erosion rate-very low to moderate, decreasing erosion hazard level-very slight to moderate, growing plants of fast growing species with significant layers and land cover, and growing interline planted primary species. Viewed from the ecological aspect, in the revegetated degraded forest lands wildlife such as insects, birds, reptiles, amphibians and small mammals were found feeding and alsopermanently living in ecosystem regeneration following gradual habitat improvement. The ecosystem status was identified as a progression towards degraded forest ecosystem recovery.
Consensus Statement on Electronic Health Predictive Analytics: A Guiding Framework
to Address Challenges
Authors: Amarasingham Ruben , Audet Anne-Marie J. , Bates David W. , Cohen I. Glenn , Entwistle Martin , Escobar G. J. , Liu Vincent , Etheredge Lynn , Lo Bernard , Ohno-Machado Lucila , Ram Sudha , Saria Suchi , Schilling Lisa M. , Shah Anand , Stewart Walter F. , Steyerberg Ewout W. , Xie Bin 
Published: March 2016

Context: The recent explosion in available electronic health record (EHR) data is
motivating a rapid expansion of electronic health care predictive analytic (e-HPA)
applications, defined as the use of electronic algorithms that forecast clinical events
in real time with the intent to improve patient outcomes and reduce costs. There is an
urgent need for a systematic framework to guide the development and application of e-HPA
to ensure that the field develops in a scientifically sound, ethical, and efficient
manner.Objectives: Building upon earlier frameworks of model development and
utilization, we identify the emerging opportunities and challenges of e-HPA, propose a
framework that enables us to realize these opportunities, address these challenges, and
motivate e-HPA stakeholders to both adopt and continuously refine the framework as the
applications of e-HPA emerge.Methods: To achieve these objectives, 17 experts with
diverse expertise including methodology, ethics, legal, regulation, and health care
delivery systems were assembled to identify emerging opportunities and challenges of
e-HPA and to propose a framework to guide the development and application of
e-HPA.Findings: The framework proposed by the panel includes three key domains where
e-HPA differs qualitatively from earlier generations of models and algorithms (Data
Barriers, Transparency, and Ethics) and areas where current frameworks are insufficient
to address the emerging opportunities and challenges of e-HPA (Regulation and
Certification; and Education and Training). The following list of recommendations
summarizes the key points of the framework:1. Data Barriers: Establish mechanisms within
the scientific community to support data sharing for predictive model development and
testing.2. Transparency: Set standards around e-HPA validation based on principles of
scientific transparency and reproducibility.3. Ethics: Develop both individual-centered
and society-centered risk-benefit approaches to evaluate e-HPA.4. Regulation and
Certification: Construct a self-regulation and certification framework within e-HPA.5.
Education and Training: Make significant changes to medical, nursing, and
paraprofessional curricula by including training for understanding, evaluating, and
utilizing predictive models.
Effects of water immersion on the recovery of upper and lower body anaerobic power following a wrestling session
Authors: Cengiz Asim , Kocak Mehmet Settar 
Published: March 2016

The aim of this study was to examine effects of cold-water immersion after exercise on powerresponses of wrestlers. Twenty elite male wrestlers were formed by similar age, height, weight and fitness parameters. The wrestling training session included a 60-minute of vigorous exercise. It consisted of warm-up exercises, standing technical and tactical exercises that mostly allocates arm and leg muscles. Vertical jump height, ropes climb height, and delayed onset of soreness was measured before, after, 24 h and 48 hors after the wrestling training. Cold-water immersion caused decrements in power loss at each follow-up time in comparison to a thermo neutral immersion. It can be suggested that the longer time needed for power to return to normal levels after cold treatment and assessment of varied contraction types may present a more broad demonstration of muscle function and consequential capacity for dynamic exercise following exercise-induced muscle damage.
Relations between teachers’ organizational justice perceptions and organizational commitment and job satisfaction in the school: A meta-analysis
Authors: Demir Kamile 
Published: March 2016

The purpose of this research study is to investigate the relationship between teachers’ organizational justice perceptions and organizational commitment and job satisfaction in the school via meta-analysis. An extensive literature search was conducted to identify both published and unpublished reports that examined the relationship between teachers’ perceptions of justice, job satisfaction and the organizational commitment to minimize potential availability bias. In total, research reports have identified providing usable data for 24 independent samples. Eight of these studies were published and 16 were unpublished dissertations. In this study, as indicator of effect size is chosen the correlation coefficient. Random effects model was preferred according to heterogeneity tests conducted for organizational commitment and job satisfaction. As a result of meta-analysis, it was found that distributive justice correlated positively with organizational commitment. There is a positive correlation between interactional justice and organizational commitment. Interactional justice has a significant relationship with organizational commitment. Teachers’ overall perception of justice was positively related to organizational commitment. The distributive justice was found to have a significant relationship with teachers’ job satisfaction. Procedural justice was found to be significantly related to the teachers’ job satisfaction. There is a positive correlation between interactional justice and teachers’ job satisfaction. Finally, organizational justice positive correlated with job satisfaction.
Experimental Study and Numerical Simulation of the Air Gap Membrane Distillation (AGMD) Process
Authors: Karbasi Ehsan , Karimi-Sabet Javad , Mohammadi Roshandeh J. , Moosavian M. A. , Ahadi H. 
Published: March 2016

Abstract
Some challenges, including inappropriate distribution of currents on the membrane surface, poor hydrodynamics and existing severe temperature polarization (TP) phenomenon in MD modules, impede industrialization of MD process. Computational fluid dynamics (CFD) method was used for numerical simulation of hydrodynamics in air gap membrane distillation modules. One of two simulated modules in this work is a novel developed one in which heat and mass transfer data was compared with available literature data. Moreover, the effect of using baffles in module was investigated. Comparison between the novel module and conventional module indicates higher trans-membrane mass flux and gained output ratio (GOR) coefficient by 7% and 15%, respectively. Moreover, the effects of different operating conditions including feed temperatures and feed flow rates on permeate flux were investigated.
The effectiveness of physical factors used in the treatment of patients with Multiple Sclerosis. Literature review
Authors: Zwolińska Jolanta , Kwolek Andrzej , Gąsior Monika 
Published: March 2016

AbstractIntroduction: Multiple Sclerosis (MS) is a chronic progressive disease of the nervous system which etiology is still unknown. Environmental factors, genetic predisposition and complex autoimmune reactions play a significant role in its pathogenesis. MS is not a fatal disease, but patients often require constant medical care and complex social welfare. Physiotherapy conducted at every stage of the disease depends on the current state of a patient and their functional capability and gradually occurring disorders and dysfunctions. Physical therapy is an important element of the therapy.Aim: To evaluate the usefulness of physical treatments used in the treatment of the MS patients.Material and methods: An analysis of domestic and foreign literature published between 2004 and 2014. The following databases were searched: PubMed, Science Direct, Termedia, Polish Medical Bibliography, Cochrane. The papers concerning the use of physical treatment as monotherapy and combination therapy were included.Summary and conclusions: Numerous research confirm both safety and efficacy of physical methods used in treatment of the MS patients. The implementation of research on the mechanism of action and effectiveness of physical factors, which are well-designed in terms of methodology, allows for the selection of the optimal physical procedure. Modern equipment and current methods of physiotherapy change views on the previously used treatments, their methodology and application.
Exposure assessment of lead from food and airborne dusts and biomonitoring in pregnant mothers, their fetus and siblings in Karachi, Pakistan and Shimotsuke, Japan
Authors: Kayama Fujio , Fatmi Zafar , Ikegami Akihiko , Mizuno Atsuko , Ohtsu Mayumi , Mise Nathern , Cui Xiaoyi , Ogawa Masanori , Sakamoto Takako , Nakagi Yoshiko , Yoshida Takahiko , Sahito Ambreen , Naeem Shahla , Ghias Kulsoom , Zuberi Hina , Tariq Kanwal , Kobayashi Yayoi , Nohara Keiko 
Published: March 2016

Abstract

Aim: Exposure assessment of lead (Pb) and Arsenic (As) from food, water, and house dust intake were assessed among pregnant women, their children and fetuses in Pakistan and Japan, as well as their body burden of the metals in their blood.

Method: Fifty families which included a pregnant woman, a fetus and the 1–3-year-old siblings were recruited in Karachi and Khairpur in Pakistan, and Shimotsuke and Asahikawa in Japan, respectively. Their dietary exposure to Pb and As was measured in 3-day food duplicates and drinking water by ICP-MP. Pb in house dust and respirable dust was evaluated with an energy dispersive X-ray fluorescence spectrometry. Non-radioactive isotope Pb profiles of blood specimens will be compared with those of the exposure origins, such as food duplicates, respirable house dust, the soils nearby, and gasoline.

Results: Judging from the data collected and analyzed so far, contribution from dietary intake is highly correlated to higher body burden of Pb among Pakistani mothers. Additional data analyses will reveal the status of Pb and As body burden in Pakistani mothers, fetuses and their siblings, and causal sources of high body burden is delineated by Pb isotope profile analysis of different sources of Pb exposure.
Community-based efforts in health promotion in indigenous villages on the Thailand-Myanmar border
Authors: Suk Ann N. 
Published: March 2016

Abstract
This case study of mainly Karen and Mon communities in Kanchanaburi Province, western Thailand, offers insight into the challenges that these rural villages face with regard to food security and environmental health issues. As non-Thai communities, these villages receive little support from the Thai government, and are often vulnerable in terms of access to food markets, infrastructure, and education and livelihood opportunities. This discussion further considers the involvement of Pattanarak Foundation, a Thai NGO, in health promotion and economic development in these villages as an example of a community partnership at the grassroots level. Examining Pattanarak’s efforts to build skills in household vegetable gardening and livestock-raising, raise awareness about child nutrition issues, and improve community sanitation illustrates the value of a participatory process, and also demonstrates some of the challenges associated with on-the-ground health promotion in disadvantaged rural communities. Applying a community-based participatory research (CBPR) framework to pursue partnerships between communities, NGOs, and researchers may offer an avenue for effective interventions to improve health in marginalized communities.
Pacific connections for health, ecosystems and society: new approaches to the land-water-health nexus
Authors: Parkes Margot W. 
Published: March 2016

AbstractRenewed effort to understand the social-ecological context of health is drawing attention to the dynamics of land and water resources and their combined influence on the determinants of health. A new area of research, education and policy is emerging that focuses on the land-water-health nexus: this orientation is applicable from small wetlands through to large-scale watersheds or river basins, and draws attention to the benefits of combined land and water governance, as well as the interrelated implications for health, ecological and societal concerns. Informed by research precedents, imperatives and collaborations emerging in Canada and parts of Oceania, this review profiles three integrative, applied approaches that are bringing attention to the importance the land-water-health nexus within the Pacific Basin: wetlands and watersheds as intersectoral settings to address land-water-health dynamics; tools to integrate health, ecological and societal dynamics at the land-water-health nexus; and indigenous leadership that is linking health and well-being with land and water governance. Emphasis is given to key characteristics of a new generation of inquiry and action at the land-water-health nexus, as well as capacity-building, practice and policy opportunities to address converging environmental, social and health objectives linked to the management and governance of land and water resources.