bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tuning in to art: A predictive processing account of negative emotion in art
Authors: Van de Cruys Sander , Chamberlain Rebecca , Wagemans Johan 
Published: November 2017

AbstractWe use the example of art-derived solace to discuss a broader mechanism by which negative affect is instrumental in creating positive appreciation of artworks. Based on the theory of predictive processing, we argue that increasing attunement or reduction of prediction errors, which implies increasing validation of the agents (models), is experienced as positive, even if the artwork's content is negative.
Kant After Marx
Authors: Love S. M. 
Published: November 2017

AbstractWhile there are many points of opposition between the political philosophies of Marx and Kant, the two can greatly benefit from one another in various ways. Bringing the ideas of Marx and Kant together offers a promising way forward for each view. Most significantly, a powerful critique of capitalism can be developed from their combined thought: Kant’s political philosophy offers a robust idea of freedom to ground this critique, while Marx provides the nuanced understanding of social and political power structures under capitalism that allows this idea of freedom to be properly applied.
Broad modulus range nanomechanical mapping by magnetic-drive soft probes
Authors: Meng Xianghe , Zhang Hao , Song Jianmin , Fan Xinjian , Sun Lining , Xie Hui 
Published: November 2017

AbstractStiffness matching between the probe and deformed portion of the sample in piezo-drive peak force modulation atomic force microscopy (AFM) limits the modulus measurement range of single probes. Here we develop a magnetic drive peak force modulation AFM to broaden the dynamic range of the probe with direct cantilever excitation. This approach not only successfully drives the softest commercial probe (6 pN nm−1) for mapping extremely soft samples in liquid but also provides an indentation force of hundreds of nanonewtons for stiff samples with a soft probe. Features of direct measurements of the indentation force and depth can unify the elastic modulus range up to four orders of magnitude, from 1 kPa to 10 MPa (in liquid) and 1 MPa to 20 GPa (in air or liquid) using a single probe. This approach can be particularly useful for analysing heterogeneous samples with large elastic modulus variations in multi-environments.
Adhesion toughness of multilayer graphene films
Authors: Wood Joseph D. , Harvey Christopher M. , Wang Simon 
Published: November 2017

AbstractInterface adhesion toughness between multilayer graphene films and substrates is a major concern for their integration into functional devices. Results from the circular blister test, however, display seemingly anomalous behaviour as adhesion toughness depends on number of graphene layers. Here we show that interlayer shearing and sliding near the blister crack tip, caused by the transition from membrane stretching to combined bending, stretching and through-thickness shearing, decreases fracture mode mixity GII/GI, leading to lower adhesion toughness. For silicon oxide substrate and pressure loading, mode mixity decreases from 232% for monolayer films to 130% for multilayer films, causing the adhesion toughness Gc to decrease from 0.424 J m−2 to 0.365 J m−2. The mode I and II adhesion toughnesses are found to be GIc = 0.230 J m−2 and GIIc = 0.666 J m−2, respectively. With point loading, mode mixity decreases from 741% for monolayer films to 262% for multilayer films, while the adhesion toughness Gc decreases from 0.543 J m−2 to 0.438 J m−2.
Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
Authors: Batson Sarah , de Chiara Cesira , Majce Vita , Lloyd Adrian J. , Gobec Stanislav , Rea Dean , Fülöp Vilmos , Thoroughgood Christopher W. , Simmons Katie J. , Dowson Christopher G. , Fishwick Colin W. G. , de Carvalho Luiz Pedro S. , Roper David I. 
Published: November 2017

AbstractD-cycloserine is an antibiotic which targets sequential bacterial cell wall peptidoglycan biosynthesis enzymes: alanine racemase and D-alanine:D-alanine ligase. By a combination of structural, chemical and mechanistic studies here we show that the inhibition of D-alanine:D-alanine ligase by the antibiotic D-cycloserine proceeds via a distinct phosphorylated form of the drug. This mechanistic insight reveals a bimodal mechanism of action for a single antibiotic on different enzyme targets and has significance for the design of future inhibitor molecules based on this chemical structure.
Major depletion of SOX2+ stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling
Authors: Roose Heleen , Cox Benoit , Boretto Matteo , Gysemans Conny , Vennekens Annelies , Vankelecom Hugo 
Published: November 2017

AbstractThe pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2+ cells through diphtheria toxin (DT)-mediated ablation. DT treatment of adult Sox2CreERT2/+;R26iDTR/+ mice (after tamoxifen-induced expression of DT receptor in SOX2+ cells) resulted in 80% obliteration of SOX2+ cells in the endocrine pituitary, coinciding with reduced pituisphere-forming activity. Counterintuitively for a stem cell population, the SOX2+ cell compartment did not repopulate. Considering the more active phenotype of the stem cells during early-postnatal pituitary maturation, SOX2+ cell ablation was also performed in 4- and 1-week-old animals. Ablation grade diminished with decreasing age and was accompanied by a proliferative reaction of the SOX2+ cells, suggesting a rescue attempt. Despite this activation, SOX2+ cells did also not recover. Finally, the major SOX2+ cell depletion in adult mice did not affect the homeostatic maintenance of pituitary hormonal cell populations, nor the corticotrope remodelling response to adrenalectomy challenge. Taken together, our study shows that pituitary SOX2+ fail to regenerate after major depletion which does not affect adult endocrine cell homeostasis and remodelling. Thus, pituitary SOX2+ cells may constitute a copious stem cell reserve or may have other critical role(s) still to be clearly defined.
Fish trader’s gender and niches in a declining coral reef fishery: implications for sustainability
Authors: McClanahan Timothy R. , Abunge Caroline 
Published: November 2017

ABSTRACT

Introduction:
The state of natural resources is greatly influenced by market access. Consequently, resource trader’s incentives, decisions, and willingness to comply with management can influence efforts to achieve sustainability. Trader’s impacts will depend on their economic niches, which are influenced by cultural norms, skill, social relationships, profitability, and the spatial scale of markets. Consequently, we examined the potential of traders to influence fisheries’ sustainability by evaluating their jobs, gender roles, religion, socioeconomic status, association and perceptions of management systems, and future plans. We studied 142 traders in 19 Kenyan coral reef fisheries landing sites distributed among four gear management systems.

Outcomes:
We found a strong role of gender, geography, and religion in the participation of these fisheries that was primarily driven by fisheries’ profitability. The associations suggest that overfished fisheries should retain traders with low education, capital, and savings – often women; whereas sustainable stocks favor the opposite characteristics, and often men.

Conclusions:
Therefore, managing for increasing yields, profits, and sustainability could exclude women traders unless they successfully access or adopt the more traditional male economic niche. Gender coexistence is most likely to be achieved by managing for intermediate resource levels where net production, catch, and fish body size diversity are high. Further, reducing risk and increasing the capital and mobility of women traders should reduce their chances of exclusion when fisheries are sustainable.
Assessing the heterogeneity of in silico plasmid predictions based on whole-genome-sequenced clinical isolates
Authors: Laczny Cedric C , Galata Valentina , Plum Achim , Posch Andreas E , Keller Andreas 
Published: November 2017

AbstractHigh-throughput next-generation shotgun sequencing of pathogenic bacteria is growing in clinical relevance, especially for chromosomal DNA-based taxonomic identification and for antibiotic resistance prediction. Genetic exchange is facilitated for extrachromosomal DNA, e.g. plasmid-borne antibiotic resistance genes. Consequently, accurate identification of plasmids from whole-genome sequencing (WGS) data remains one of the major challenges for sequencing-based precision medicine in infectious diseases. Here, we assess the heterogeneity of four state-of-the-art tools (cBar, PlasmidFinder, plasmidSPAdes and Recycler) for the in silico prediction of plasmid-derived sequences from WGS data. Heterogeneity, sensitivity and precision were evaluated by reference-independent and reference-dependent benchmarking using 846 Gram-negative clinical isolates. Interestingly, the majority of predicted sequences were tool-specific, resulting in a pronounced heterogeneity across tools for the reference-independent assessment. In the reference-dependent assessment, sensitivity and precision values were found to substantially vary between tools and across taxa, with cBar exhibiting the highest median sensitivity (87.45%) but a low median precision (27.05%). Furthermore, integrating the individual tools into an ensemble approach showed increased sensitivity (95.55%) while reducing the precision (25.62%). CBar and plasmidSPAdes exhibited the strongest concordance with respect to identified antibiotic resistance factors. Moreover, false-positive plasmid predictions typically contained only few antibiotic resistance factors. In conclusion, while high degrees of heterogeneity and variation in sensitivity and precision were observed across the different tools and taxa, existing tools are valuable for investigating the plasmid-borne resistome. Nevertheless, additional studies on representative clinical data sets will be necessary to translate in silico plasmid prediction approaches from research to clinical application.
Regulation of low-density lipoprotein cholesterol by intestinal inflammation and the acute phase response
Authors: Herbert Karl E , Erridge Clett 
Published: November 2017

AbstractSystemic inflammation, induced by disease or experimental intervention, is well established to result in elevated levels of circulating triglycerides, and reduced levels of high-density lipoprotein-cholesterol (HDL-C), in most mammalian species. However, the relationship between inflammation and low-density lipoprotein-cholesterol (LDL-C) concentrations is less clear. Most reports indicate that systemic inflammation, as observed during sepsis or following high dose experimental endotoxaemia, lowers total, and LDL-C in man. However, isolated reports have suggested that certain inflammatory conditions are associated with increased LDL-C. In this review, we summarize the emerging evidence that low-grade inflammation specifically of intestinal origin may be associated with increased serum LDL-C levels. Preliminary insights into potential mechanisms that may mediate these effects, including those connecting inflammation to trans-intestinal cholesterol efflux (TICE), are considered. We conclude that this evidence supports the potential downregulation of major mediators of TICE by inflammatory mediators in vitro and during intestinal inflammation in vivo. The TICE-inflammation axis therefore merits further study in terms of its potential to regulate serum LDL-C, and as a readily druggable target for hypercholesterolaemia.
Discovery of electron cyclotron MASER emission from the magnetic Bp star HD 133880 with the Giant Metrewave Radio Telescope
Authors: Das Barnali , Chandra Poonam , Wade Gregg A 
Published: November 2017

Abstract
We report the discovery of coherent radio emission from the young, rapidly rotating magnetic Bp star HD 133880 at a frequency of 610 MHz with the Giant Metrewave Radio Telescope (GMRT). This is only the second magnetic star in which coherent radio emission has been detected. In our observations of HD 133880 covering the full rotational cycle of the star (except for a phase window 0.17–0.24), we witness an abrupt order-of-magnitude flux enhancement along with ≈100 per cent right circular polarization. We attribute this phenomenon to coherent electron cyclotron MASER emission. We attribute the lack of left circularly polarized emission to the asymmetric topology of the star's magnetic field. The phase of enhancement, 0.73, differs from the previously reported phase of enhancement, 0.16, (at 610 MHz)by one-half cycle. However, no flux enhancement is found at phase 0.16 in our data, which could be due to an unstable or drifting emission region, or a consequence of the reported changes of the star's rotational period. Either of these factors could have shifted the enhancement to the above-mentioned phase window not sampled by our observations.
NaV1.7 and pain: contribution of peripheral nerves
Authors: Hoffmann Tal , Sharon Ohad , Wittmann Jürgen , Carr Richard W. , Vyshnevska Alina , Col Roberto De , Nassar Mohammed A. , Reeh Peter W. , Weidner Christian 
Published: November 2017

Abstract
The sodium channel NaV1.7 contributes to action potential (AP) generation and propagation. Loss-of-function mutations in patients lead to congenital indifference to pain, though it remains unclear where on the way from sensory terminals to central nervous system the signalling is disrupted. We confirm that conditional deletion of NaV1.7 in advillin-expressing sensory neurons leads to impaired heat and mechanical nociception in behavioural tests. With single-fiber recordings from isolated skin, we found (1) a significantly lower prevalence of heat responsiveness to normally mechanosensitive C-fibers, although (2) the rare heat responses seemed quite vigorous, and (3) heat-induced calcitonin gene-related peptide release was normal. In biophysical respects, although electrical excitability, rheobase, and chronaxy were normal, (4) axonal conduction velocity was 20% slower than in congenic wild-type mice (5) and when challenged with double pulses (<100 milliseconds interval), the second AP showed more pronounced latency increase (6). On prolonged electrical stimulation at 2 Hz, (7) activity-dependent slowing of nerve fiber conduction was markedly less, and (8) was less likely to result in conduction failure of the mutant single fibers. Finally, recording of compound APs from the whole saphenous nerve confirmed slower conduction and less activity-dependent slowing as well as the functional absence of a large subpopulation of C-fibers (9) in conditional NaV1.7Adv knockouts. In conclusion, the clear deficits in somatic primary afferent functions shown in our study may be complemented by previously reported synaptic dysfunction and opioidergic inhibition, together accounting for the complete insensitivity to pain in the human mutants lacking NaV1.7.
Computed Tomography–Based Imaging of Voxel-Wise Lesion Water Uptake in Ischemic Brain
Authors: Broocks Gabriel , Flottmann Fabian , Ernst Marielle , Faizy Tobias Djamsched , Minnerup Jens , Siemonsen Susanne , Fiehler Jens , Kemmling Andre 
Published: November 2017

Objectives
Net water uptake per volume of brain tissue may be calculated by computed tomography (CT) density, and this imaging biomarker has recently been investigated as a predictor of lesion age in acute stroke. However, the hypothesis that measurements of CT density may be used to quantify net water uptake per volume of infarct lesion has not been validated by direct volumetric measurements so far. The purpose of this study was to (1) develop a theoretical relationship between CT density reduction and net water uptake per volume of ischemic lesions and (2) confirm this relationship by quantitative in vitro and in vivo CT image analysis using direct volumetric measurements.

Materials and Methods
We developed a theoretical rationale for a linear relationship between net water uptake per volume of ischemic lesions and CT attenuation. The derived relationship between water uptake and CT density was tested in vitro in a set of increasingly diluted iodine solutions with successive CT measurements. Furthermore, the consistency of this relationship was evaluated using human in vivo CT images in a retrospective multicentric cohort. In 50 edematous infarct lesions, net water uptake was determined by direct measurement of the volumetric difference between the ischemic and normal hemisphere and was correlated with net water uptake calculated by ischemic density measurements.

Results
With regard to in vitro data, water uptake by density measurement was equivalent to direct volumetric measurement (r = 0.99, P < 0.0001; mean ± SD difference, −0.29% ± 0.39%, not different from 0, P < 0.0001). In the study cohort, the mean ± SD uptake of water within infarct measured by volumetry was 44.7 ± 26.8 mL and the mean percent water uptake per lesion volume was 22.7% ± 7.4%. This was equivalent to percent water uptake obtained from density measurements: 21.4% ± 6.4%. The mean difference between percent water uptake by direct volumetry and percent water uptake by CT density was −1.79% ± 3.40%, which was not significantly different from 0 (P < 0.0001).

Conclusions
Volume of water uptake in infarct lesions can be calculated quantitatively by relative CT density measurements. Voxel-wise imaging of water uptake depicts lesion pathophysiology and could serve as a quantitative imaging biomarker of acute infarct lesions.
Disruption to functional networks in neonates with perinatal brain injury predicts motor skills at 8 months
Authors: Linke Annika C. , Wild Conor , Zubiaurre-Elorza Leire , Herzmann Charlotte , Duffy Hester , Han Victor K. , Lee David S.C. , Cusack Rhodri 
Published: November 2017

AbstractObjectiveFunctional connectivity magnetic resonance imaging (fcMRI) of neonates with perinatal brain injury could improve prediction of motor impairment before symptoms manifest, and establish how early brain organization relates to subsequent development. Methods: This cohort study is the first to describe and quantitatively assess functional brain networks and their relation to later motor skills in neonates with a diverse range of perinatal brain injuries. Infants (n=65, included in final analyses: n=53) were recruited from the neonatal intensive care unit (NICU) and were stratified based on their age at birth (premature vs. term), and on whether neuropathology was diagnosed from structural MRI. Functional brain networks and a measure of disruption to functional connectivity were obtained from 14 minutes of fcMRI acquired during natural sleep at term-equivalent age.ResultsDisruption to connectivity of the somatomotor and frontoparietal executive networks predicted motor impairment at 4 and 8 months. This disruption in functional connectivity was not found to be driven by differences between clinical groups, or by any of the specific measures we captured to describe the clinical course.ConclusionfcMRI was predictive over and above other clinical measures available at discharge from the NICU, including structural MRI. Motor learning was affected by disruption to somatomotor networks, but also frontoparietal executive networks, which supports the functional importance of these networks in early development. Disruption to these two networks might be best addressed by distinct intervention strategies.
Effect of product involvement and brand prominence on advergamers’ brand recall and brand attitude in an emerging market context
Authors: Vashist Devika 
Published: November 2017

Purpose
The purpose of this paper is to investigate the impact of product involvement and brand prominence on advergamers’ brand recall and brand attitude in an emerging market context. Specifically, this research illustrates the conditions under which brand placements in online games create attention, elaboration and subsequent brand recall and brand attitude by drawing the insights from the limited capacity model of attention and the elaboration likelihood model.

Design/methodology/approach
A 2 (product involvement: low or high) × 2 (brand prominence: prominent or subtle) between-subject measures design is used. In total, 280 students participated in the study. A 2×2 between-subjects MANOVA is used to test the hypotheses.

Findings
In the context of advergames, for a low-involvement product, a prominent brand placement results in greater brand recall than a subtle brand placement. However, for a high-involvement product, a subtle-placement results in greater brand recall than a prominent brand placement. Further, results reveal that for a low-involvement product, a subtle brand placement results in more favorable brand attitude than a prominent brand placement. For a high-involvement product, a prominent brand placement results in more favorable brand attitude than a subtle brand placement.

Research limitations/implications
The findings and conclusions are very important for advertising experts in terms of advergame designing, execution and for an operational use of brand placements in advergames.

Originality/value
This investigation adds to the online advertising literature, specifically the advergames context by examining and analyzing the real-time roles of advergame-specific factor, such as brand prominence and the gamer-specific factor, such as product involvement in creating gamers’ brand recall and brand attitude from attention and elaboration perspectives in an emerging market context like India.
Understanding and predicting antecedents of mobile shopping adoption
Authors: Madan Khushbu , Yadav Rajan 
Published: November 2017

PurposeThe purpose of this paper is to determine the key factors influencing mobile shopping adoption intention and actual usage in the backdrop of the moderating effect of gender and age.Design/methodology/approachThe study identifies eight independent variables including two relatively new variables, i.e. perceived regulatory support (PRS) and perceived benefits, and proposes an integrated framework to understand mobile shopping behavior. A total of 304 mobile device users were surveyed using a comprehensive questionnaire. The collected data were utilized to analyze the hypothesized relationships through structural equation modeling.FindingsThe results indicated that all the factors considered in the framework were significant in predicting mobile shopping behavioral intention (BI) except for PRS. Demographic variables such as age and gender moderate the effect of factors such as perceived critical mass, personal innovativeness and hedonic motivation on mobile shopping BI.Research limitations/implicationsThe small sample sizes and a possibility to include new variables other than consumer-centric factors are some of the limitations of this study.Practical implicationsThe findings of this paper are of significant use for mobile shopping app developers, mobile payment gateway providers and other institutions involved in facilitation and provision of such mobile shopping services to develop suitable strategies to encourage adoption of mobile devices as a medium of online shopping.Originality/valueThe study is first of its kind in India and integrates variables from different areas of technology adoption along with two new variables, i.e PRS and perceived benefits to understand mobile shopping behavior.