bluuebunny/crossref_metadata_2025_split huggingface dataset:
Carbon quantum dots composite for enhanced selective detection of dopamine with organic electrochemical transistors
Authors: Gamboa Jillian , el Attar Reem , Thuau Damien , Estrany Francesc , Abbas Mamatimin , Torras Juan 
Published: October 2024

Abstract A compact organic electrochemical transistors (OECT) sensor enriched with carbon quantum dots (CQDs) was developed to enhance the transconductance of an electropolymerized poly(3,4-ethylenedioxythiophene) (PEDOT) film, enabling the precise and selective detection of dopamine (DA). Accurate monitoring of DA levels is critical for diagnosing and managing related conditions. Incorporating CQDs, we have achieved a remarkable up to threefold increase in current at the DA detection peak in differential pulse voltammetry. This enhancement showcases superior selectivity even in the presence of high concentrations of interferents like uric acid and ascorbic acid. This material significantly boosts the sensitivity of OECTs for DA detection, delivering an amperometric response with a detection limit of 55 nM and a broader detection range (1 − 500 µM). Our results underscore the potential of low-dimensional carbonaceous materials in creating cost-effective, high-sensitivity devices for detecting DA and other biomolecules. This breakthrough sets the stage for the development of next-generation biosensors for point-of-care diagnostics.
Graphical Abstract
Gesundheitsberufliche und spezialisierte Spiritual Care
Authors: Peng-Keller Simon 
Published: October 2024

Zusammenfassung

Hintergrund
Als evidenzbasierter Einbezug der spirituellen Dimension in klinische Kontexte entwickelt sich Spiritual Care gegenwärtig als ein interprofessionelles Aufgabenfeld und interdisziplinäres Forschungsgebiet, das auch für die Onkologie von Bedeutung ist. Das Bemühen, die spirituelle Dimension in die moderne Gesundheitsversorgung zu integrieren, reicht weit zurück und wurde in der 2. Hälfte des 20. Jahrhunderts sowohl von der Hospizbewegung als auch von der Weltgesundheitsorganisation (WHO) aufgegriffen und verstärkt. Im Kontext religiös-spiritueller Diversifizierung steht Spiritual Care unter dem Anspruch, einer wachsenden Vielfalt an Vorstellungen und Bedürfnissen zu entsprechen.

Methodik
Im vorliegenden Übersichtsartikel werden Hintergründe und Inhalte der aktuellen Diskussion um interprofessionelle Spiritual Care und klinische Seelsorge skizziert und analysiert. Es wird beschrieben, inwiefern Spiritual Care auch eine gesundheitsberufliche Aufgabe darstellt und sich klinische Seelsorge als spezialisierte Spiritual Care verstehen lässt.

Schlussfolgerungen
Es lassen sich 3 Hauptgründe nennen, weshalb spirituelle Aspekte in der onkologischen Versorgung angesprochen und einbezogen werden sollten: (1) weil die Konfrontation mit einer schweren Erkrankung oder dem Lebensende spirituellen Distress auslösen kann; (2) weil spirituelle Faktoren im Umgang mit Krankheit und Sterben nicht selten eine Ressource oder ein Problem darstellen; (3) weil spirituelle Überzeugungen und Haltungen therapeutische Entscheidungen beeinflussen können.
Imagining Letting Go: a Preliminary Test of Written Imagery Rescripting to Facilitate Discarding in a High Hoarding Sample
Authors: Sabel Isaac , Yap Keong , Grisham Jessica R. 
Published: October 2024

AbstractMental images appear to be important mental events in hoarding that may maintain the disorder by interfering with discarding. We tested whether a novel written imagery rescripting task, focused on modifying a negative imagined outcome of discarding a hoarded object into a positive alternative, could be used to promote discarding in individuals with hoarding traits, and compared this against other cognitive-behavioural strategies used to encourage discarding. We also examined whether the success of imagery rescripting depended on imagining ability. High hoarding participants (n = 176), recruited through Cloudresearch.com, were asked to imagine a negative outcome of discarding an object they were still attached to. We then randomized them into one of four conditions: imagery rescripting, imaginal exposure, cognitive restructuring, or a positive imagery control, and presented them with a discarding task. Rescripting was associated with increased readiness and motivation to discard, and discarding frequency, compared to other conditions. Rescripting also reduced state negative emotions and increased state positive emotions relative to exposure and restructuring. We found reductions in object attachment in rescripting, restructuring, and positive imagery. The effect of rescripting on readiness and motivation to discard was moderated by imagining ability, such that higher imagining ability was associated with greater readiness and motivation to discard after rescripting. Pending replication and extension, written imagery rescripting may have promise as a clinical strategy to facilitate discarding in individuals with hoarding difficulties.
Trends in Lower-Risk Gambling by Age and Net Income among Finnish Men and Women in 2011, 2015, and 2019
Authors: Grönroos Tanja , Kontto Jukka , Young Matthew M. , Hodgins David C. , Salonen Anne H. 
Published: October 2024

Abstract
Lower-risk Gambling Guidelines (LRGGs) were developed in Canada to reduce the risk of gambling-related harm. The LRGGs, published in 2021, consist of three limits: gamble no more than 1% of household income per month; gamble no more than four days per month; and avoid regularly gambling at more than two types of games. All three limits should be followed at the same time. This study focuses on the situation in Finland before the LRGGs were published. The aim of this study is to investigate trends in lower-risk gambling by age and net income among men and women in the Finnish adult population in 2011, 2015, and 2019. Data were drawn from cross-sectional Finnish Gambling population surveys, including permanent residents in Mainland Finland aged 15–74 with Finnish, Swedish or Sámi as their mother tongue (2011; n = 4,484, 2015; n = 4,515, and 2019; n = 3,994). The results showed an increase in the prevalence of lower-risk gambling, rising from 29% in 2011 to 39% in 2019. This upward trend was observed among both men and women, with the prevalence among men increasing from 23 to 33%, and among women from 34 to 45%. The lowest prevalence of lower-risk gambling was found among individuals aged 60–74, especially regarding expenditure guidelines, as well as among women in the lowest income tertile. In conclusion, although the prevalence of lower-risk gambling has increased in Finland, there is still potential for further improvement to minimize harm.
Leveraging a Dual Organisation-Development (OD) Process: A Longitudinal Study of a Start-up’s Transformation in the Energy Sector
Authors: Rubach Synnøve 
Published: October 2024

AbstractThis paper explores the transformative journey of a start-up company in the energy sector, employing a Dual Organisation-Development (OD) Process, as conceptualised within the co-generative learning/organisation development (OD) model. Originating from a doctoral thesis, this research unveils the application of the dual OD process in a longitudinal study of a start-up’s pursuit to revolutionise the Energy Attribute Certificates (EACs) market through digitalisation. The company aimed to connect energy users directly with renewable energy producers, ensuring transparency and traceability of the renewable origin of energy. Initiated through the “DIgitalised Node-trading for renewable energy with GO (DINGO)” project, the start-up received funding from a Norwegian research fund called Oslofjordfondet, propelling the development of a digitalised platform and the underlying research. This paper documents the dynamic interplay between daily business operations and the DINGO project, presenting the dual OD process as a bridged, facilitated intraorganisational and interorganisational development mechanism. Grounded in participatory organisation development and the cogenerative learning model, the study draws on historical written sources and insider perspectives. The research unfolds three key dimensions of the dual OD process within the start-up. Firstly, the research-based innovation project itself serves as a continuous learning and maturing process, reshaping the company over time. Secondly, the project opens avenues for accessing crucial financial, technological, and human resources, fostering new interorganisational collaborations. Thirdly, the project introduces friction between the research project and daily business operations, propelling the business model into unforeseen pathways, resulting in intraorganisational changes. To enhance the depth of the study, a reflection dialogue with the project owner were conducted in the spring 2024, offering a hindsight reflection on the effectiveness of the dual OD process in enhancing project outcomes and its continued application within the company. The paper contributes to understanding the pivotal role of research in early-stage business development, introducing the dual OD process as a valuable model for comprehending the intricate interaction between daily business operations, business modelling, and research projects. It also pays homage to Professor Morten Levin, highlighting the enduring influence of his mentorship and the co-generative learning model. In addition, entrepreneurs can derive practical insights from the dual OD model, providing a framework for navigating the challenges and opportunities inherent in combining business modelling and research, thereby facilitating successful business development.
Deformation Mechanisms of (100) and (110) Single-Crystal BCC Gum Metal Studied by Nanoindentation and Micropillar Compression
Authors: Jarząbek Dariusz M. , Włoczewski Mateusz , Milczarek Michał , Jenczyk Piotr , Takesue Naohisa , Golasiński Karol M. , Pieczyska Elżbieta A. 
Published: October 2024

AbstractIn this paper, small-scale testing techniques—nanoindentation and micropillar compression—were used to investigate the deformation mechanisms, size effects, and strain rate sensitivity of (100) and (110) single-crystal Gum Metal at the micro/nanoscale. It was observed that the (100) orientation exhibits a significant size effect, resulting in hardness values ranging from 1 to 5 GPa. Conversely, for the (110) orientation, this effect was weaker. Furthermore, the yield strength obtained from the micropillar compression tests was approximately 740 MPa for the (100) orientation and 650 MPa for the (110) orientation. The observed deformations were consistent with the established features of the deformation behavior of body-centered cubic (bcc) alloys: significant strain rate sensitivity with no depth dependence, pile-up patterns comparable to those reported in the literature, and shear along the {112}<111> slip directions. However, the investigated material also exhibited Gum Metal-like high ductility, a relatively low modulus of elasticity, and high yield strength, which distinguishes it from classic bcc alloys.
Supported g-C3N4/WO3 mixed layers for photocatalytic water remediation
Authors: Brabec Libor , Mikyskova Eliska , Zin Olha , Walderova Barbora , Zouzelka Radek , Rathousky Jiri , Weers Marco , Schechterle Arne , Wark Michael 
Published: October 2024

Abstractg-C3N4 layers with good mechanical properties, including their cohesion and adhesion to stainless-steel supports, were prepared by the quantitative electrophoretic co-deposition of g-C3N4 and WO3 nanocrystals. It was carried out in a mixture of organic solvents by applying a voltage of 750 V. The typical layer area density was 0.64 mg cm–2. The photocatalytic degradation of 4-chlorophenol under blue-light irradiation showed that the performance of stable composite layers containing 25–50 wt.% of WO3 was only slightly weaker than that of unstable pristine g-C3N4 ones. The high photocatalytic performance was due to g-C3N4, while WO3 contributed to a good mechanical resistance of layers in stirred water. Finally, the composite layers exhibited a very high 4-chlorophenol mineralization of 75% in 24 h, even higher than the corresponding suspensions. Owing to their stability in water and performance, the developed layers are suitable for applications in environmental technologies.
Graphic Abstract
The Role of Subcutaneous Furosemide in Heart Failure Management: A Systematic Review
Authors: Widiarti Wynne , Saputra Pandit Bagus Tri , Ariyanto Melissa Valentina , Savitri Cornelia Ghea , Multazam Chaq El Chaq Zamzam , Putranto Johanes Nugroho Eko , Alkaff Firas Farisi 
Published: October 2024

Abstract
Background
Acute decompensated heart failure (ADHF) patients with symptomatic congestion often require in-hospital admission for intravenous (IV) diuretic, impacting both patient well-being and healthcare expenses. Subcutaneous (SC) furosemide has a potential to facilitate outpatient management of ADHF patients. Thus, this study aims to assess the efficacy and safety of SC furosemide utilization, offering a potential alternative to traditional IV administration.

Methods
A systematic search was conducted until April 14 2024 across scientific databases. This review included studies comparing SC furosemide with oral and IV formulations in adult HF patients.

Results
This study analyzed 687 patients from 20 studies. The results demonstrate that SC furosemide can effectively manage symptomatic congestion in HF patients and results in significant cost reductions, symptom relief, and improved quality of life. Although further investigation into mortality rates is needed, SC furosemide demonstrates efficacy comparable to IV furosemide in diuresis and weight loss, with similar bioavailability and natriuretic effects. Adverse events are generally minor, predominantly related to skin irritation. Innovative strategies, such as developing isotonic alkaline solutions and improved infusion devices, are being explored to address these challenges.

Conclusion
SC furosemide offers a promising alternative for managing ADHF, particularly in symptomatic HF patients with volume overload. The integration of SC furosemide into routine clinical practice and future guidelines, could optimize the management of HF, reducing hospital admission and improving patient outcomes.
Glycoprofile Comparison of the SARS-CoV-2 Spike Proteins Expressed in CHO and HEK Cell Lines
Authors: Wright Helen L. , Evans Caroline , Jackson Philip J. , James David C. , Tee Kang Lan , Wong Tuck Seng , Dickman Mark J. , Pandhal Jagroop 
Published: October 2024

AbstractCoronavirus SARS-CoV-2 spike protein remains a key focus of research due to a continued need for diagnostic and therapeutic tools to monitor and respond to new variants. Glycosylation of the spike protein is critical for the protein’s functions in viral attachment and host cell entry. For scalable and cost-effective production of the spike protein, expression system-driven divergence in glycosylation patterns on recombinant spike proteins needs to be fully understood. This study assessed the N-glycosylation profiles of a full-length trimeric spike protein expressed in either Human Embryonic Kidney (HEK Expi293F) or Chinese Hamster Ovary (CHO-S) cells. Glycopeptide analysis was performed using a tandem mass spectrometry workflow and BioPharma $${\hbox {Finder}}^{\textrm{TM}}$$

Finder

TM

incorporating HEK and CHO glycan databases for protein characterisation. The results outline important differences in the variety and types of N-glycan generated by the two cell lines across the 22 known N-glycosylation sites of the spike protein. A notable increase in terminal sialylation, as well as the presence of the potentially immunogenic N-glycolylneuraminic acid at a functionally key N-glycosylation site, was observed in the CHO-S derived spike protein. With the potential for the relatively vast and more complex CHO glycan repertoire (182 glycans relative to 39 human glycans) to produce functional implications with CHO-S expressed spike protein, this study adds valuable knowledge to aid Quality by Design approaches and enable Multi Attribute Monitoring of specific N-glycosylation sites for proteoform analyses. This can further inform antigen development with future variants in order to devise updated diagnostic tests and therapeutic vaccine designs.
Analysing cross-border logistics operations for performance improvement: development and validation of a reference model
Authors: Bandaranayake Namal , Kiridena Senevi , Kulatunga Asela K. , Dam Hoa 
Published: October 2024

AbstractThe critical role played by cross-border logistics (CBL) systems in sustaining fast, efficient and responsive global supply chains is widely recognised. However, scholarly research focusing on CBL systems is limited, which means that theoretical frameworks and methodological approaches available for analysing and improving CBL operations are underdeveloped. As such, coordination among diverse stakeholders, meeting regulatory requirements, adapting to a rapidly evolving technological environment, and limited capacity for investing in high-value assets, all remain ongoing challenges hindering the smooth and swift flow of cargo across borders. With a view to addressing these challenges and research gaps, this paper develops a reference model for analysing and improving CBL-specific processes. Seven underlying process dimensions have been identified following a rigorous methodological approach for the modelling, analysis and improvement of CBL operations. The efficacy of the reference model is demonstrated using two purposive case applications. The reference model also helps identify potential technological interventions to improve operations and benchmark CBL systems, operations and processes.
Exploring the Ability of ChatGPT to Act as a Research Aid in Otolaryngology
Authors: Shaari Ariana L. , Herzog Isabel , Kokush Emily , Zabielski Sylvia , Langer Sydney , Filimonov Andrey 
Published: October 2024

AbstractRecently artificial intelligence (AI) platforms have developed at a rapid pace. To date no studies have explored AI platform ChatGPT’s ability to serve as an aid in research in the field of otolaryngology. The objective of our study is to evaluate the ability of ChatGPT to generate unique research ideas relevant to Otolaryngology. ChatGPT was tasked to generate novel research project ideas. Seven categories for all otolaryngology subspecialties were created: general otolaryngology, facial plastics and reconstructive surgery, rhinology and skull base surgery, pediatrics, head and neck oncology, laryngology, and otology/neurotology. Within each of the subspecialties, ChatGPT was prompted to provide research ideas for two specific research topics in order to gauge ChatGPT’s ability to explore specific domains. Ten prompts were entered for general otolaryngology, and five prompts were entered for each subspecialty and subspecialty topic. ChatGPT was subsequently prompted with the same query to generate systematic review ideas for each category. Ideas were deemed novel if there were no similar systematic reviews retrieved during the literature review on PubMed, Scopus, or Web of Science. Ideas were graded for Clinical Relevance on a scale of 0 to 5, 5 being considered highly relevant/would contribute greatly to patient care and 0 being considered not relevant/not beneficial to patient care. Two reviewers graded each response. Out of 100 systematic review ideas generated by ChatGPT, we found that the artificial intelligence platform was incapable of creating unique systematic review research ideas. However, the ideas that it did generate were largely feasible and clinically relevant. Future studies should investigate the ability of ChatGPT to generate research inquiries with non-systematic review methodologies and in more specific otolaryngology topics.
Species richness − environmental diversity relationships are shaped by the underlying species − area curves and negative secondary effects
Authors: Lamont Byron B. , Pausas Juli G. 
Published: October 2024

Abstract
Background
The relationship between the environmental (ED) or habitat (HD) diversity of a landscape and its species richness (S) is of global interest. The standard linear relationship tested is that total S rises with an increase in variability of environmental properties.

Findings
We recognize three basic S − ED patterns: convex, unimodal, and concave. These are shown to be based on three underlying species − area (S − A) curves: power, logarithmic, and sigmoid. From these, we find that the standard linear relationship lacks theoretical support. There are two sets of circumstances that can lead to a humped relationship: a particular type of S-A curve (logarithmic), and the operation of negative secondary effects as habitats become smaller and more isolated. The preponderance of positive linear and dearth of unimodal S − ED and S − HD relationships reported so far can be attributed to six causes. These include: only testing for linear relationships; limited data sets that exclude small, unique, or isolated habitats; regressions against non-causal variables; and/or use of biased data that have not been ground-truthed.

Conclusions
Informed by the underlying S − A curves and the level of negative biotic effects at high ED, one can predict the numerous shapes of the S − ED curve. Hump-backed S − ED curves should apply widely in regions with species-rich biotas and where the environmental range is large and numerous isolated habitats are present.
Unconscious Perception, Action, and the Problem of Attribution
Authors: Zięba Paweł Jakub 
Published: October 2024

AbstractAccording to Phillips, (1) genuine perception is attributable to the individual (i.e. it is a personal state/event, as opposed to sub-personal states/events in the individual’s brain); (2) since unconscious perceptual representations are ill-suited to guide action, there is no good reason to attribute them to the individual; (3) not being attributable to the individual, they do not instantiate genuine perception, thereby failing to support the hypothesis that genuine perception can occur unconsciously. I argue that this reasoning is flawed and cannot be easily fixed. Phillips contends that unconscious perceptual representations do not guide action because they fail to meet certain conditions that are sufficient for action guidance. But those conditions may not be necessary for action guidance. Consequently, unconscious perceptual representations may guide action even if they do not meet Phillips’ conditions. Furthermore, due to his commitment to the distinction between personal and sub-personal states/events, Phillips is not in a position to argue that his conditions are necessary for action guidance. For the distinction applies to action as well as to perception, and when genuine action is identified by personal-level criteria, Phillips’ conditions turn out unnecessary for action guidance.
Sharp Weighted Non-tangential Maximal Estimates via Carleson-Sparse Domination
Authors: Rosén Andreas 
Published: October 2024

Abstract
We prove sharp weighted estimates for the non-tangential maximal function of singular integrals mapping functions from

$${\textbf{R}}^n$$

R

n

to the half-space in

$${\textbf{R}}^{1+n}$$

R

1
+
n

above

$${\textbf{R}}^n$$

R

n

. The proof is based on pointwise sparse domination of the adjoint singular integrals that map functions from the half-space back to the boundary. It is proved that these map

$$L_1$$

L
1

functions in the half-space to weak

$$L_1$$

L
1

functions on the boundary. From this a non-standard sparse domination of the singular integrals is established, where averages have been replaced by Carleson averages.