bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mediterranean diet after prostate cancer diagnosis and urinary and sexual functioning: The health professionals follow‐up study
Authors: Bauer Scott R. , Van Blarigan Erin L. , Stampfer Meir J. , Chan June M. , Kenfield Stacey A. 
Published: December 2017

BackgroundMen with prostate cancer often experience urinary and sexual dysfunction after treatment. Previous studies have demonstrated a relationship between dietary factors and these symptoms among men with diabetes or metabolic syndrome. However, there are limited data on whether diet after prostate cancer diagnosis, including a Mediterranean dietary pattern, affects urinary and sexual function among prostate cancer survivors.MethodsMen diagnosed with non‐metastatic prostate cancer in the Health Professionals Follow‐up Study (n = 2960) from 1986 to 2012 were prospectively followed for a median of 8.3 years after treatment. Participants completed validated dietary questionnaires every 4 years and a health‐related quality of life assessment in 2010 or 2012. We used generalized linear models to examine associations between post‐diagnosis Mediterranean Diet Score (including individual score components and dietary fat subtypes) and quality of life domains (sexual functioning, urinary irritation/obstruction, urinary incontinence) assessed using the Expanded Prostate Cancer Index Composite Short Form (score 0‐100; higher scores indicate better function).ResultsNo statistically significant relationships were observed between the Mediterranean Diet Score after prostate cancer diagnosis and urinary or sexual function. However, the associations did vary depending on pre‐diagnosis urinary and sexual dysfunction for urinary irritation/obstruction and sexual function scores, respectively (P‐interactions < 0.0001). Men with higher post‐diagnosis vegetable intake reported higher urinary incontinence scores (72 vs 76 comparing lowest to highest quintile; P‐trend = 0.003). Similarly, higher vegetable intake and lower polyunsaturated fat intake were associated with higher urinary irritation/obstruction scores (vegetable: 80 vs 84 comparing lowest to highest quintile, P‐trend = 0.01; polyunsaturated fat: 84 vs 78 comparing lowest to highest quintile, P‐trend = 0.005), however these associations were observed only among men with urinary symptoms prior to their prostate cancer diagnosis.ConclusionsAmong men with prostate cancer, diet intake after diagnosis was not significantly associated with urinary or sexual function, although some relationships appeared to differ among men with and without symptoms prior to their prostate cancer diagnosis. Higher vegetable intake and lower polyunsaturated fat intake after prostate cancer diagnosis may be associated with better urinary function. However, this analysis was exploratory, and further research is needed to better delineate these relationships and guide dietary recommendations for men with prostate cancer.
Material properties determining the insecticidal activity of highly divided porous materials on the pharaoh ant (Monomorium pharaonis)
Authors: Van Den Noortgate Heleen , Lagrain Bert , Pulinthanathu Sree Sreeprasanth , Kerkhofs Stef , Wenseleers Tom , Martens Johan A 
Published: December 2017

AbstractBACKGROUNDHistorically, inert insecticidal powders such as diatomaceous earth were researched for pest management applications, and it was revealed that these types of powders killed insects by desiccation. However, data on the critical material properties that affect their efficacy are sparse. The present study investigated the insecticidal effect of powdered materials on the pharaoh ant, a notorious domestic pest.RESULTSThe insecticidal activity of 24 porous materials was tested. Eight of these materials performed better than the benchmark, diatomaceous earth. Zeolite Y and carbon black II performed best, inducing 50% mortality within 40 and 55 minutes, respectively. Statistical analysis of seven material properties revealed that macroporous surface area and Brunauer–Emmett–Teller (BET) specific surface area were most predictive of insecticidal activity. For zeolites and ordered mesoporous silica materials, the most important parameters were, respectively, BET and large mesopore surface area. Finally, gas chromatography–mass spectrometry (GC–MS) analysis confirmed the adsorption of epicuticular hydrocarbons onto the zeolite powders.CONCLUSIONThis study shows clear potential for the use of environmentally friendly, inert porous materials as insecticides against the pharaoh ant and identified the key material properties influencing insecticidal activity. The GC–MS data support the hypothesis that the mortality was caused by the removal of the protective epicuticular hydrocarbons. © 2017 Society of Chemical Industry
Spinosad‐mediated effects on the walking ability, midgut, and Malpighian tubules of Africanized honey bee workers
Authors: Lopes Marcos Pereira , Fernandes Kenner Morais , Tomé Hudson Vaner Ventura , Gonçalves Wagner Gonzaga , Miranda Franciane Rosa , Serrão José Eduardo , Martins Gustavo Ferreira 
Published: December 2017

AbstractBACKGROUNDThe global decline in Apis mellifera colonies is attributed to multiple factors, including pesticides. The bioinsecticide spinosad was initially recognized as safe for non‐target organisms; however, its toxicity has been changing this view. Here, we investigated the survival, behavioral changes, and structural changes in the midgut and Malpighian tubules of A. mellifera treated orally with a spinosad formulation.RESULTSThe field‐recommended concentration of spinosad killed 100% of the bees. The 5% and 50% lethal concentrations (LC5 and LC50, respectively) of spinosad altered the behavioral activity, reducing the walking distance and velocity, and increased the resting time in comparison to the control. The LC50 caused disorganization of the epithelia of tested organs and induced oxidative stress and cell death.CONCLUSIONSThe present work provides new insights into the debate about the role of bioinsecticides in the mortality of Africanized honey bees. Even at very low concentrations, the spinosad formulation was toxic to the vital organs midgut and Malpighian tubules and adversely affected walking behavior. This detailed evaluation of the impact of the bioinsecticide on A. mellifera will contribute to the clarification of disturbances probably caused by spinosad formulations, which can be used to develop more sustainable protocols in agriculture. © 2017 Society of Chemical Industry
Trends in the diffusion of robotic surgery: A retrospective observational study
Authors: Marcus Hani J. , Hughes‐Hallett Archie , Payne Christopher J. , Cundy Thomas P. , Nandi Dipankar , Yang Guang‐Zhong , Darzi Ara 
Published: December 2017

AbstractBackgroundRecent studies have suggested that the use of robotic surgery for prostatectomy has been increasing, but characterization of the diffusion of robotic surgery in other procedures has not been available.MethodsData were analysed for the years 2006–2014 using hospital episode statistics (HES), a database of all admissions to National Health Service (NHS) hospitals in England. OPCS codes were used to determine the annual number of prostatectomy, partial nephrectomy, and total abdominal hysterectomy procedures. Concurrent OPCS codes were then used to identify whether these procedures were robotic, conventional laparoscopic or open surgery.ResultsThe proportion of robotic cases varied depending on the surgical procedure. Diffusion of robotic surgery was relatively rapid in prostatectomy, moderate in partial nephrectomy, and slow in total abdominal hysterectomy.ConclusionsAlthough high institutional cost might explain the earliest delays in diffusion, this barrier does not fully account for the different rates of diffusion among surgical procedures.
What factors affect the suspended sediment concentrations in rivers? A study of the upper Warta River (Central Poland)
Authors: Skolasińska K. , Nowak B. 
Published: December 2017

AbstractThe suspended sediment concentration (SSC) of the Warta River was analysed using data collected at the Sieradz gauging station (Central Poland) during the period of 1961–1980. The aim of the study was to characterize the trend in the suspended sediment transported over this multi‐annual period and search for possible correlations between the suspended sediment values and the discharge and thermal seasonality factors. This study also investigated whether the SSC is affected by anthropogenic factors. The SSC in the river water increased over the analysed 20‐year period. It was caused mainly by the training works in the Warta valley upstream of Sieradz and the opening of the Bełchatów lignite mine. No direct relationship between the SSC and fluctuations in the discharge was noted. A connection existed between the SSC and ice phenomena on the river. The river ice breakup was often coincident with increases in SSC; however, the SSC increased rapidly during the freezing of the river. There was also a positive correlation between the SSC and the temperature of the water during the summer half‐year, which resulted from the growth of phytoplankton. This process was supported by the general warming trend observed in the river water and by an increase in the quantity of nutrients noted since the early 1970s. It is worth emphasizing that the relationships established between the SSC and the studied factors are not always unequivocal and repetitive. It follows that, as a rule, the SSC is influenced by more factors than are actually considered in this study.
A Pilot Study of Mesenchymal Stem Cell Therapy for Acute Liver Allograft Rejection
Authors: Shi Ming , Liu Zhenwen , Wang Ying , Xu Rounan , Sun Yanling , Zhang Min , Yu Xi , Wang Hongbo , Meng Lingzhan , Su Haibin , Jin Lei , Wang Fu-Sheng 
Published: December 2017

Abstract
Acute allograft rejection remains common after liver transplantation despite modern immunosuppressive agents. In addition, the long-term side effects of these regimens, including opportunistic infections, are challenging. This study evaluated the safety and clinical feasibility of umbilical cord-derived mesenchymal stem cell (UC-MSC) therapy in liver transplant patients with acute graft rejection. Twenty-seven liver allograft recipients with acute rejection were randomly assigned into the UC-MSC infusion group or the control group. Thirteen patients received one infusion of UC-MSCs (1 × 106/kg body weight); one patient received multiple UC-MSC infusions; 13 patients were used as controls. All enrolled patients received conventional immunosuppressive agents with follow-up for 12 weeks after UC-MSC infusions. No side effects occurred in treated patients. Four weeks after UC-MSC infusions, alanine aminotransferase levels had decreased markedly and remained lower throughout the 12-week follow-up period. Importantly, allograft histology was improved after administration of UC-MSCs. The percentage of regulatory T cells (Tregs) and the Treg/T helper 17 (Th17) cell ratio were significantly increased 4 weeks after infusions; in contrast, the percentage of Th17 cells showed a decreasing trend. In controls, the percentages of Tregs and Th17 cells and the Treg/Th17 ratio were statistically unchanged from the baseline measurements. Transforming growth factor beta 1 and prostaglandin E2 were increased significantly after UC-MSC infusions; by contrast, there were no significant changes in controls. Our data suggest that UC-MSC infusion for acute graft rejection following liver transplantation is feasible and may mediate a therapeutic immunosuppressive effect.
New Hybrid Nanomaterials Derived from Chemical Functionalization of Clicked Graphene Oxide / Magnetite Nanocomposite with Peroxopolyoxotungstate Species
Authors: Masteri‐Farahani Majid , Modarres Maryam 
Published: December 2017

AbstractTwo new hybrid nanomaterials were developed by immobilization of peroxopolyoxotungstate on the surface of clicked graphene oxide/magnetite nanocomposite. First, graphene oxide/magnetite nanocomposite was produced through the thiol‐ene click reaction of graphene oxide with mercaptopropyl‐functionalized magnetite nanoparticles in the presence of benzoyl peroxide. Then, the prepared graphene oxide/magnetite nanocomposite was functionalized with (3‐aminopropyl)triethoxysilane or cysteamine hydrochloride as spacer groups for the subsequent immobilization of peroxopolyoxotungstate species. The prepared hybrid nanomaterials exhibited high activities and complete selectivities (>99%) in the epoxidation of olefins with H2O2 under mild reaction conditions. In addition, they can be magnetically separated and reused several times without remarkable loss of catalytic efficiency.
A Novel and Template‐Free Synthesis of Multifunctional Double‐Shelled Fe3O4‐C Nanoreactor as an Ideal Support for Confined Catalytic Reactions
Authors: Arora Gunjan , Yadav Manavi , Gaur Rashmi , Gupta Radhika , Sharma Rakesh K. 
Published: December 2017

AbstractA novel, facile and straightforward approach is developed to fabricate magnetic carbon nanoreactor consisting of multi‐functional double‐layered shell, large void space, tailored dimensions, and high surface area. The presented strategy involves unexampled one‐pot combination of gas‐bubble assisted Ostwald ripening method and polymerization of resorcinol‐formaldehyde. The inner Fe3O4 layer imparts the nanoreactor with superparamagnetic character and thereby, simplifies its separation from the reaction media. The outermost carbon shell protects the inner layer from harsh external environment and also provides additional sites for metal decoration. The internal cavity of the nanoreactor was easily filled with copper metal. Thus, due to the presence of large number of catalytic active sites and the advantages of hollow architecture, Cu@Fe3O4‐C exhibited excellent catalytic activity with perfect reusability for the oxidative bromination reaction. This work indicates that magnetic porous carbon nanoreactor could provide an ideal support for the immobilization of metals in the urge to develop highly efficient catalysts.
Fe(III)‐Exchanged Montmorillonite as Reusable Heterogeneous Protonic Acid Catalyst for Michael Addition of Indole in Water
Authors: Matsuzawa Ryosuke , Nishimura Shun , Ebitani Kohki 
Published: December 2017

AbstractFe3+‐exchanged montmorillonite (Fe3+‐mont) was found to be an effective and a reusable heterogeneous acid catalyst for the Michael addition of indole with methyl vinyl ketone at 333 K in H2O to afford 4‐(1H‐indol‐3‐yl)butan‐2‐one in high yields. Investigations on activity of the Fe3+‐mont catalyst for deprotection of acetal and Meerwein‐Ponndorf‐Verley (MPV) reduction of aldehyde suggest that protonic acid sites of the Fe3+‐mont catalyst are responsible for the present Michael addition of indole.
In Silico Exploration of Vinca Domain Tubulin Inhibitors: A Combination of 3D‐QSAR‐Based Pharmacophore Modeling, Docking and Molecular Dynamics Simulations
Authors: Lone Mohsin Y. , Athar Mohd , Manhas Anu , Jha Prakash C. , Bhatt Shruti , Shah Anamik 
Published: December 2017

AbstractA predictive ligand based quantitative pharmacophore model has been constructed to extract the essential features accountable for the inhibition of vinca domain inhibitors. To generate pharmacophore model a set of 23 functionally diverse training compounds was exploited by employing the Phase algorithm. The statistically significant (R2=0.81, Q2=0.61, RMSE=0.63 and Pearson‐R=0.79) five feature pharmacophore model consist of one hydrogen‐bond acceptor, one hydrogen‐bond donor, a hydrophobic feature, one positive ionizable and a ring aromatic feature was chosen to screen the ZINC natural product database of IBScreen. The retreived hits were subjected to molecular docking examination by using FlexX. Furthermore, the dynamic behaviour and conformational features of the top scored docked molecule was envisioned via molecular dynamics simulations. The rationale behind the present work was to bid healthier perceptive about the binding of the tubulin inhibitors and abet in discovering new leads with potent antitumor activities.
Highly Porous Silicon Nanowires Made with Solvent‐Mediated Wet Chemical Etching and Their Thermoelectric Applications
Authors: Tang Chien‐Hsin , Li Wen‐Jin , Hung Chia‐Hsiang , Hsiao Po‐Hsuan , Chen Chia‐Yun 
Published: December 2017

AbstractPorous silicon (Si) nanostructures with heavily doping concentrations possess many intriguing properties different from bulk Si, but the fabrication remains greatly challenging for the large‐quantity production. Therefore, in this study, the heavily doped Si nanowires with highly porous features were prepared using a co‐solvent mediated metal‐assisted chemical etching (MaCE). Unlike the conventional MaCE method with sole water as solvents, the mixed co‐solvents, with the addition of highly volatile methanol at ambient temperature are found to facilitate the significant sidewall etching through the evaporation of solvents when etching reaction proceeds. In addition, thermoelectric performances of incorporating such porous Si nanowires as inclusions with (BiSb)2Te3 particles as matrix were investigated. The beneficial effects, examined from three various amounts of Si nanowires dispersed in (BiSb)2Te3 matrix, are originated from the supplement of increased carrier concentrations. Meanwhile, the increase of thermal conductivity is not obvious due to the existence of porous Si nanowires, thus leading to the improved figure of merit (ZT) value, which is more than 1.3 times higher than that of pure (BiSb)2Te3 samples.
Pyronin B‐Graphene Oxide‐Based Turn‐On Fluorescent Sensors for Fe3+ in an Aqueous Medium: Synthesis and Living Cell Application
Authors: Batir Gokhan Guven , Gedikli Semin , Arik Mustafa 
Published: December 2017

AbstractPyronin B (PyB)–graphene oxide (GO) is reported for metal‐ion sensing since it is based fluorescent sensor. PyB–GO nanocomposites are synthesized in aqueous solution by Ultrasonic Homogenizers. The structure of PyB–GO nanocomposites is characterized with X‐ray diffraction (XRD),Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, UV–vis spectroscopy and Fluorescence Microscopy. PyB–GO binary system are studied for the sensing ability in the detection of metal ions as a fluorescent sensor. It shows high sensitivity and selectivity for Fe3+ metal ions in aqueous medium as a result of the spectroscopic data.
Hollow Semiconductor Nanospheres‐Anchored Graphene Oxide Sheets for Effective Microwave Absorption
Authors: Biswas Sourav , Dutta Suvanka , Panja Sujit S. , Bose Suryasarathi 
Published: December 2017

AbstractConsiderable attention has been given in recent years towards the development of electromagnetic interference (EMI) shielding materials. In spite of the fact that leading polymer composites containing different magnetic and dielectric nanofillers have been used broadly, nevertheless, the impact of inorganic semiconducting nanomaterials has not been utilized fully. Herein, we have designed hollow ZnS nanospheres doped reduced graphene oxide sheets (rGO) via template‐free, one‐pot hydrothermal synthesis process and fabricated nanocomposites with poly(vinylidene fluoride), PVDF as matrix. Three dimensional conducting network of rGO sheets along with high interacting surface area with heterogeneous dielectrics led to a very high total shielding effectiveness (−40 dB) with 93% absorption. The underlying mechanism, supported by skin‐depth estimation and attenuation constant, is discussed in detail. This study opens new avenues in the field of EMI shielding materials as inorganic semiconductors show promising results in contrast to traditional materials involving conducting, dielectric and magnetic nanoparticles embedded polymer nanocomposites.
Absolute Configuration of Eight Cephalimysins Isolated from the Marine‐Derived Aspergillus fumigatus.
Authors: Yamada Takeshi , Kimura Hiroyuki , Arimitsu Kenji , Kajimoto Tetsuya , Kikuchi Takashi , Tanaka Reiko 
Published: December 2017

AbstractEight new metabolites with spiro‐heterocyclic γ‐lactam cores, cephalimysins E–L, were isolated from a culture broth of Aspergillus fumigatus that was originally separated from the marine fish Mugil cephalus. In spite of the presence of six chiral centers in cephalimysins E–L, no other diastereomers of them were isolated from the natural source except for eight unnatural forms that could be obtained by treating cephalimysins E–L with acidic methanol. The occurrence of cephalimysins E–L was rationalized via molecular energy calculations by assuming that these isomers were derived from annelation of a spiro‐heterocyclic γ‐lactam with an E‐olefin on the side chain such as the E‐isomer of pseurotin A. Biosynthetic consideration of the metabolites based on molecular orbital calculations demonstrated that the 16 stereoisomers can all exist, and their stereochemistry was unambiguously determined using circular dichroism spectra, nuclear Overhauser effect spectroscopy, and two‐dimensional nuclear magnetic resonance spectra.
A remote marking device and newly developed permanent dyes for Wildlife research
Authors: Baird Patricia , Robinette Dan , Hink Scot A. 
Published: December 2017

ABSTRACTNoninvasive, safe, quick marking of individual animals using distinctive colors that are highly visible and persistent is a valuable methodology, but practical techniques and permanent safe dyes are lacking. Here we describe a novel, remotely controlled dye machine to rapidly mark stationary animals in predictable locations, such as birds sitting on nests on the ground or mammals at a den or burrow site. From the month of June when birds were on eggs, using the machine, we spot‐dyed 77 California least terns (Sternula antillarum browni) at a colony in California, USA, in 4 days without handling them. Concomitantly, we developed a suite of permanent (until molt or shedding), mainly phthalocyanine dyes that are incorporated chemically into feathers or fur of animals and cannot be preened or rubbed off, which have never been used before to dye animals. We found no toxicity of the dyes during in vivo testing over 1 month. This method of remote marking with permanent dyes should prove to be a useful method in animal ecology for distinguishing among individuals with minimal disturbance. © 2017 The Wildlife Society.
Effective dose and persistence of Rhodamine‐B in wild pig Vibrissae
Authors: Webster Sarah C. , Cunningham Fred L. , Kilgo John C. , Vukovich Mark , Rhodes Olin E. , Beasley James C. 
Published: December 2017

ABSTRACTAs a result of substantial ecological and economic damage attributed to wild pigs (Sus scrofa), there is international interest in using pharmaceutical baits to control populations. To assess the efficacy and specificity of baiting programs, chemical biomarkers can be used to evaluate uptake of pharmaceutical baits. Rhodamine B (RB) is known to be an effective biomarker in wild pigs. However, significant data gaps exist regarding the minimum effective dosage and persistence of RB in wild pigs. We used a controlled double‐blind study experiment conducted in spring of 2014 on the Savannah River Site, Aiken, South Carolina, USA, wherein we administered a one‐time dose of RB at 3 treatment levels (5 mg/kg, 15 mg/kg, or 30 mg/kg) to 15 captive pigs, with 5 pigs/treatment group to investigate persistence of RB. Facial vibrissae were collected pre‐RB ingestion as a control and every 2 weeks post‐RB ingestion for 12 weeks. We examined samples for RB presence and used a generalized linear mixed model (GLMM) to determine the influence of treatment dose on persistence of RB. Additionally, we measured distance moved by the RB mark away from the vibrissae root and used a GLMM to assess movement rates of RB bands along growing vibrissae. We found consistently greater persistence of RB in the 15‐ and 30‐mg/kg treatments across the sampling period. A significant, positive movement trend in RB bands was observed within the 15 mg/kg and 30 mg/kg groups. Based on our results, a 15 mg/kg dosage can be considered a minimum effective dose for wild pigs and will reliably produce a detectable RB mark up to and likely beyond 12 weeks after ingestion. © 2017 This article is a U.S. Government work and is in the public domain in the USA.