bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anion‐ and Solvent‐Induced Assembly and Reversible Structural Transformation of d10‐Metal Coordination Architectures Containing N‐(4‐(4‐Aminophenyloxy)phenyl)isonicotinamide
Authors: Tzeng Biing‐Chiau , Hung Yu‐Ching , Lee Gene‐Hsiang 
Published: December 2015

AbstractWe set out studies on anion‐ and solvent‐induced assembly based on the ligand N‐(4‐(4‐aminophenyloxy)phenyl)isonicotinamide (papoa), which is synthesized to show a bent and flexible backbone. Reactions of papoa with ZnX2 (X=Cl, Br, and I) gave the dinuclear macrocycles ([ZnX2(papoa)]2; X=Cl (1 a), Br (2 a), I (3)), the structure of which was determined by X‐ray diffraction. Notably, the less bulky Cl and Br compounds afforded the coordinated imine in acetone (i.e., [ZnX2(papoi)]2, papoi=N‐(4‐(4‐(propan‐2‐ylideneamino)phenoxy)phenyl)isonicotinamide; X=Cl (1 b), Br (2 b)), whereas the iodine one only gave the coordinated amine compound 3 under the same reaction condition. In fact, the coordinated imine can return to the amine analogue upon exposure to air or in DMSO, which has been monitored by 1H NMR spectroscopy and powder X‐ray diffraction. Both the dinuclear [Zn(papoa)(NO3)2]2 (4 a) and the 1D [Zn(papoa)2(NO3)2]n (4 b) were formed from the reaction of Zn(NO3)2 and papoa in mixed solvents with acetone and acetonitrile, respectively. In addition, Cd(ClO4)2 can react with papoa to give the 1D framework {[Cd(papoa)2(CH3CN)2](ClO4)2}n (5 a) and the 2D framework [Cd(papoa)2(ClO4)2]n (5 b), depending on the solvent used, that is, MeOH and CH3CN, respectively. Importantly, the 1D framework with axially coordinated CH3CN molecules and the 2D framework with axially coordinated ClO4− ions can be interconverted by heating and grinding in the presence of CH3CN, respectively. Such a reversible structural transformation process was proven by PXRD studies.
[U(bipy)4]: A Mistaken Case of U0?
Authors: Fortier Skye , Veleta José , Pialat Amélie , Le Roy Jennifer , Ghiassi Kamran B. , Olmstead Marilyn M. , Metta‐Magaña Alejandro , Murugesu Muralee , Villagrán Dino 
Published: December 2015

AbstractAfter more than 50 years, the synthesis and electronic structure of the first and only reported “U0 complex” [U(bipy)4] (1) has been reinvestigated. Additionally, its one‐electron reduced product [Na(THF)6][U(bipy)4] (2) has been newly discovered. High resolution crystallographic analyses combined with magnetic and computational data show that 1 and its derivative 2 are best described as highly reduced species containing mid‐to‐high‐valent uranium ligated by redox non‐innocent ligands.
The rise of concurrent care for veterans with advanced cancer at the end of life
Authors: Mor Vincent , Joyce Nina R. , Coté Danielle L. , Gidwani Risha A. , Ersek Mary , Levy Cari R. , Faricy‐Anderson Katherine E. , Miller Susan C. , Wagner Todd H. , Kinosian Bruce P. , Lorenz Karl A. , Shreve Scott T. 
Published: December 2015

BACKGROUNDUnlike Medicare, the Veterans Health Administration (VA) health care system does not require veterans with cancer to make the “terrible choice” between receipt of hospice services or disease‐modifying chemotherapy/radiation therapy. For this report, the authors characterized the VA's provision of concurrent care, defined as days in the last 6 months of life during which veterans simultaneously received hospice services and chemotherapy or radiation therapy.METHODSThis retrospective cohort study included veteran decedents with cancer during 2006 through 2012 who were identified from claims with cancer diagnoses. Hospice and cancer treatment were identified using VA and Medicare administrative data. Descriptive statistics were used to characterize the changes in concurrent care, hospice, palliative care, and chemotherapy or radiation treatment.RESULTSThe proportion of veterans receiving chemotherapy or radiation therapy remained stable at approximately 45%, whereas the proportion of veterans who received hospice increased from 55% to 68%. The receipt of concurrent care also increased during this time from 16.2% to 24.5%. The median time between hospice initiation and death remained stable at around 21 days. Among veterans who received chemotherapy or radiation therapy in their last 6 months of life, the median time between treatment termination and death ranged from 35 to 40 days. There was considerable variation between VA medical centers in the use of concurrent care (interquartile range, 16%‐34% in 2012).CONCLUSIONSConcurrent receipt of hospice and chemotherapy or radiation therapy increased among veterans dying from cancer without reductions in the receipt of cancer therapy. This approach reflects the expansion of hospice services in the VA with VA policy allowing the concurrent receipt of hospice and antineoplastic therapies. Cancer 2016;122:782–790. © 2015 American Cancer Society.
Facile Synthesis of Nanostructured MnO2 as Anode Materials for Sodium‐Ion Batteries
Authors: Zhang Zhian , Zhao Xingxing , Li Jie 
Published: December 2015

AbstractNanostructured MnO2 (including nanorods and nanoflowers) has been synthesized by a simple two‐step hydrothermal method and thermal treatment. When employed as anode materials for sodium‐ion batteries, MnO2 nanorods and nanoflowers demonstrate high initial sodium ion storage capacities of 427.4 and 487.8 mA h g−1, respectively, at a current density of 50 mA g−1. Compared with MnO2 nanorods, MnO2 nanoflowers achieved a much better electrochemical performance including good rate capability (103.3 mA h g−1 at 800 mA g−1 after 100 cycles) and superior cyclability (133.6 mA h g−1 at 400 mA g−1 after 1000 cycles). The good performance can be ascribed to the nanocrystalline nature and the three‐dimensional hierarchical architecture of MnO2 nanoflowers, which promotes the contact between MnO2 and electrolyte and shortens the electronic sodium ion pathway in the charge and discharge processes.
Detection of Plasmon Coupling between Silver Nanowires Based on Hyperspectral Darkfield and SERS Imaging and Supported by DDA Theoretical Calculations
Authors: Santos Jonnatan J. , Ivanov Evandro , dos Santos Diego P. , Toma Henrique E. , Corio Paola 
Published: December 2015

AbstractWe report the unprecedented observation of plasmon coupling between silver nanowires, showing how the surface‐enhanced Raman scattering depends upon this interaction and how the spectrum can be shaped by the hot spot. Such observations were accomplished by Raman spectroscopy mapping of silver nanowires modified with rhodamine. The local spectra on the hot spots were measured by darkfield hyperspectral microscopy, a powerful but uncommonly used technique that is capable of determining the location, structure, and spectra of the hot spots. The result obtained by the simulation of two parallel nanowires based on the discrete dipole approximation (DDA) method was in excellent agreement with the results obtained experimentally.
Synthesis of Perdeuterated 1‐Palmitoyl‐2‐oleoyl‐sn‐glycero‐3‐phosphocholine ([D82]POPC) and Characterisation of Its Lipid Bilayer Membrane Structure by Neutron Reflectometry
Authors: Yepuri Nageshwar R. , Darwish Tamim A. , Krause‐Heuer Anwen M. , Leung Anna E. , Delhom Robin , Wacklin Hanna P. , Holden Peter J. 
Published: December 2015

Abstract1‐Palmitoyl‐2‐oleoyl‐sn‐glycero‐3‐phosphocholine (POPC), an unsaturated acyl chain containing lipid, is often the predominant lipid in eukaryotic cell membranes in which it is crucial for the fluidity of membranes under physiological conditions. Commercially available, partially deuterated [D31]1‐palmitoyl‐2‐oleoyl‐sn‐glycero‐3‐phosphocholine ([D31]POPC) does not provide sufficient isotopic contrast for detailed structural studies of multicomponent membranes through neutron techniques. Herein, a relatively straightforward and generic chemical deuteration method is discussed for the asymmetric synthesis of perdeuterated [D31]1‐palmitoyl‐[D33]2‐oleoyl‐sn‐[D5]glycero‐[D13]3‐phosphocholine ([D82]POPC) that also allows selective deuteration of any of its constituent groups. Neutron reflectivity of a [D82]POPC‐supported bilayer was used to experimentally determine the neutron scattering length density profile of the lipid. The acyl chains of [D82]POPC are closely contrast‐matched to heavy water, whereas the very high scattering length density of the deuterated glycerophosphocholine head groups provides good contrast to membrane‐binding agents in both deuterated and non‐deuterated solvent environments.
Effects of root mat buoyancy and heterogeneity on floating fen hydrology
Authors: Stofberg Sija F , van Engelen Joeri , Witte Jan‐Philip M , van der Zee Sjoerd EATM 
Published: December 2015

AbstractFloating fen ecosystems are home to several protected habitats and species. Their development and conservation require special attention regarding water management. Although they are known to be heterogeneous and partially buoyant, their root mats are simulated in hydrological models as homogeneous, static systems. The objective of this study is to quantify root mat heterogeneity and buoyancy and to assess their effects on groundwater flow and transport, and to determine if these factors need to be taken into account in modelling.We conducted field measurements of root mat heterogeneity and buoyancy in the ‘Nieuwkoopse Plassen’, the Netherlands. We found that hydraulic conductivity varied over four orders of magnitude and negatively correlated with degree of decomposition, resulting in a zonation of high conductivity near the surface and low conductivity in the deeper layers. Also, we found that the root mat moved vertically with the surface water. It became more buoyant with higher temperatures, but less buoyant with increasing groundwater levels relative to the surface.We implemented the findings in a semi‐steady state hydrological model of a floating fen to compare the effects with other parameters. The profound heterogeneity had a limited effect on the water budget, but a clear effect on the flow lines and thus should be taken into account when modelling transport processes in floating fens. Although buoyancy affected the relative groundwater level near the root mat edge, it did not affect the water budget or the flow lines and may therefore be neglected in water budget modelling. Copyright © 2015 John Wiley & Sons, Ltd.
Plasma growth hormone is a strong predictor of risk at 1 year in acute heart failure
Authors: Bhandari Sanjay S. , Narayan Hafid , Jones Donald J.L. , Suzuki Toru , Struck Joachim , Bergmann Andreas , Squire Iain B. , Ng Leong L. 
Published: December 2015

AbstractAimsWe sought to compare the prognostic utility of growth hormone (GH) with NT‐proBNP) and the ADHERE score in a large cohort of acute heart failure (HF) patients, subcategorized into HF with reduced EF <50% (HFrEF) and preserved EF ≥50% (HFpEF).Methods and resultsGH and NTproBNP levels were measured in 537 patients (HFrEF n = 415; HFpEF n = 122) with acute HF recruited into this prospective cohort study. The main outcome measure was death or HF readmission at 1 year. GH levels were higher in both HFrEF [1.26 (0.54–2.62) vs. 0.8 (0.26–1.94) ng/mL, P < 0.001] and HFpEF [1.04 (0.48–2.92) vs. 0.53 (0.18–1.94) ng/mL, P = 0.020] patients with the outcome compared with event‐free survivors. GH levels were independently predictive for the outcome at 1 year in the entire cohort [HR 1.47, 95% confidence interval (CI) 1.16–1.86, P = 0.001] and those with HFrEF (HR 1.54, 95% CI 1.19–1.99, P = 0.001) in multivariate Cox hazard analysis. GH improved risk classification as measured by continuous net reclassification improvement (NRI) when added to the ADHERE multivariate logistic model of age, sex, urea, heart rate, and systolic blood pressure, for all patients [NRI 29.6 (12.1–47.1), P = 0.001] and HFrEF NRI 21.7 (1.9–41.6), P = 0.034] patients, as well as in addition to the ADHERE model combined with NT‐proBNP for all patients [NRI 25.4 (7.8–43.1), P = 0.005].ConclusionsGH offers incremental prognostic information over the ADHERE score clinical predictors and NT‐proBNP for risk stratification of acute HF patients.
Correlating the Structural and Photo­physical Features of Pincer Luminophores and Monodentate Ancillary Ligands in PtII Phosphors
Authors: Galstyan Anzhela , Naziruddin Abbas Raja , Cebrián Cristina , Iordache Adriana , Daniliuc Constantin G. , De Cola Luisa , Strassert Cristian A. 
Published: December 2015

AbstractInvited for the cover of this issue are Prof. Luisa De Cola and Priv.‐Doz. Cristian A. Strassert from the Westfälische Wilhelms‐Universität Münster, Germany. The cover image shows a series of bright PtII complexes with improved excited state properties.
Optical and Electrochemical Properties of Anthraquinone Imine Based Dyes for Dye‐Sensitized Solar Cells
Authors: Prinzisky Christian , Meyenburg Ingo , Jacob Andreas , Heidelmeier Benjamin , Schröder Fabian , Heimbrodt Wolfram , Sundermeyer Jörg 
Published: December 2015

AbstractA number of anthraquinone imines (1–3, 5–8) and an anthrone diamine (4) have been synthesized by the condensation of 9,9‐dimethoxy‐10‐anthrone derivatives (13, 18, and 23) with different primary aromatic amines and, in the case of benzoacridinone 7, by a subsequent photoinduced 6 electrocyclization. All the compounds were fully characterized by UV/Vis spectroscopy, cyclic voltammetry, and X‐ray diffraction. The XRD analyses proved that the preferred tautomers of 1, 3, and 5 have the 9‐amino‐1,10‐anthraquinone or 1‐hydroxy‐9,10‐anthraquinone imine core. Furthermore, aminoanthraquinone 9 and phenoxazine 10 were synthesized by the reaction of 1‐amino‐9,10‐anthraquinone with 3,5‐di‐tert‐butylphenyl‐o‐benzoquinone, which led to dyes with high molar extinction coefficients of up to 101600 L mol–1 cm–1. In addition, the absorption maxima of the 1‐hydroxy‐9,10‐anthraquinone imines appear in the range of 246 and 591 nm, at variance with the absorption maxima of the parent 1‐hydroxy‐9,10‐anthraquinone. The cyclic voltammograms of all the compounds show multiple redox processes. In addition, the optical absorption and photoluminescence spectra of 3 show suppressed segregation on mesoporous TiO2 and an almost pure molecule photoluminescence spectrum containing two main transitions. A new excitonic transition was found in the crystal form.
Western environment/lifestyle is associated with increased genome methylation and decreased gene expression in Chinese immigrants living in Australia
Authors: Zhang Guicheng , Wang Kui , Schultz Ennee , Khoo Siew‐Kim , Zhang Xiaopeng , Annamalay Alicia , Laing Ingrid A. , Hales Belinda J. , Goldblatt Jack , Le Souëf Peter N. 
Published: December 2015

Introduction: Several human diseases and conditions are disproportionally distributed in the world with a significant “Western‐developed” vs. “Eastern‐developing” gradient.Methods: We compared genome‐wide DNA methylation of peripheral blood mononuclear cells in 25 newly arrived Chinese immigrants living in a Western environment for less than 6 months (“Newly arrived”) with 23 Chinese immigrants living in the Western environment for more than two years (“Long‐term”) with a mean of 8.7 years, using the Infinium HumanMethylation450 BeadChip. In a sub‐group of both subject groups (n = 12 each) we also investigated genome‐wide gene expression using a Human HT‐12 v4 expression beadChip.Results: There were 62.5% probes among the total number of 382,250 valid CpG sites with greater mean Beta (β) in “Long‐term” than in “Newly arrived”. In the regions of CpG islands and gene promoters, compared with the CpG sites in all other regions, lower percentages of CpG sites with mean methylation levels in “Long‐term” greater than “Newly arrived” were observed, but still >50%. The increase of methylation was associated with a general decrease of gene expression in Chinese immigrants living in the Western environment for a longer period of time. After adjusting for age, gender and other confounding factors the findings remained.Conclusion: Chinese immigrants living in Australia for a longer period of time have increased overall genome methylation and decreased overall gene expression compared with newly arrived immigrants. Environ. Mol. Mutagen. 57:65–73, 2016. © 2015 Wiley Periodicals, Inc.
Flexible Operation of Fixed‐Bed Reactors for a Catalytic Fuel Synthesis—CO2 Hydrogenation as Example Reaction
Authors: Iglesias González María , Eilers Hilko , Schaub Georg 
Published: December 2015

AbstractIt may become attractive in the future to operate fuel‐related chemical reactions, with H2 as reactant, under flexible load conditions when H2 is produced through H2O electrolysis using fluctuating renewable energy. In this way, the size of the H2 storage device connected to the electrolysis cell can be reduced and, consequently, its investment costs. The design of a flexible reactor depends on the characteristics of the catalyst and the chemical reaction. CO2 hydrogenation over Fe catalysts to short‐chain hydrocarbons, which can be used to adjust the heating value of substitute natural gas, is investigated as example reaction. A specific reactor design for flexible operation with gas recycling is a consequence of the constraints resulting from product partial pressures and reaction temperature. The experimental and mathematical methods developed can be applied to other fuel‐synthesis processes.
Rheological, baking, and sensory properties of composite bread dough with breadfruit (Artocarpus communis Forst) and wheat flours
Authors: Bakare Adegoke H. , Osundahunsi Oluwatooyin F. , Olusanya Joseph O. 
Published: December 2015

AbstractThe rheological (Pasting, farinograph, and alveograph) properties of wheat flour (WF) replaced with breadfruit four (05–40%) was analyzed. Baking and sensory qualities of the resulting bread were evaluated. Differences in baking properties of loaves produced under laboratory and industrial conditions were analyzed with t‐test, whereas ANOVA was used for other analyses. Peak and final viscosities in the composite blends (CB) ranged from 109.20 to 114.06 RVU and 111.86 to 134.40 RVU, respectively. Dough stability decreased from 9.15 to 0.78 min, whereas farinograph water absorption increased 59.7–65.9%. Alveograph curve configuration ratio increased from 1.27 to 7.39, whereas specific volume (Spv) of the loaves decreased from 2.96 to 1.32 cm3/g. The Spv of WF loaves were not significantly different (P > 0.05) from that of the 5% CB, whereas production conditions had no significant effects on absorbed water (t = 0.532, df = 18 P = 0.3005), weight loss during baking (t = 0.865, df = 18, P = 0.199), and Spv (t = 0.828, df = 14.17, P = 0.211). The sensory qualities of the 5% blend were not significantly different from the WF.
A study on the physicochemical parameters for Penicillium expansum growth and patulin production: effect of temperature, pH, and water activity
Authors: Tannous Joanna , Atoui Ali , El Khoury André , Francis Ziad , Oswald Isabelle P. , Puel Olivier , Lteif Roger 
Published: December 2015

AbstractPenicillium expansum is among the most ubiquitous fungi disseminated worldwide, that could threaten the fruit sector by secreting patulin, a toxic secondary metabolite. Nevertheless, we lack sufficient data regarding the growth and the toxigenesis conditions of this species. This work enables a clear differentiation between the favorable conditions to the P. expansum growth and those promising for patulin production. A mathematical model allowing the estimation of the P. expansum growth rate according to temperature, aW, and pH, was also developed. An optimal growth rate of 0.92 cm/day was predicted at 24°C with pH level of 5.1 and high aW level of 0.99. The model's predictive capability was tested successfully on artificial contaminated apples. This model could be exploited by apple growers and the industrialists of fruit juices in order to predict the development of P. expansum during storage and apple processing.
Incompletely Fractured Families
Authors: McCallum Peter , Lang Moshe 
Published: December 2015

The modern family is increasingly isolated and increasingly unstable. As a result, family therapists are faced with a variety of problems in families where the parents have separated or divorced. One previously unrecognised problem occurs when the partners, although separated, covertly remain attached to the old alliance. Frequently a child, by becoming “ill”, remains as a bridge between them to prevent the final disintegration of the marriage bond.Three case histories are provided as an illustration of this phenomenon.
Pharmacokinetics, Mechanisms of Action, Indications, and Adverse Effects of Timolol Maleate, A Nonselective Beta‐Adrenoreceptor Blocking Agent
Authors: Dunn Francis G. , Frohlich Edward D. 
Published: December 2015

Timolol, a nonselective beta‐adrenoreceptor blocking agent without intrinsic sympathomimetic or membrane stabilizing activity, has been shown effective in the treatment of angina and hypertension. It is particularly useful in patients with stable angina pectoris and patients with mild to moderate hypertension. In both of these conditions, timolol appears to be comparable to propranolol. A recent study has suggested that timolol reduces mortality and reinfarction rate in patients who have recently had a myocardial infarction. When given topically timolol reduces intraocular pressure in patients with open‐angle glaucoma; the drug may be used as the primary agent or as an adjunct to standard therapy.Careful selection of patients will reduce the frequency of adverse effects due to beta‐receptor inhibition. Thus, timolol should not be used in patients who are predisposed to asthmatic bronchitis or cardiac failure, and it should be used with caution in patients with peripheral vascular disease or diabetes mellitus.
Mechanism of Action, Antimicrobial Activity, Pharmacology, Adverse Effects, and Clinical Efficacy of Cefotaxime
Authors: LeFrock Jack L. , Prince Randall A. , Left Richard D. 
Published: December 2015

Cefotaxime sodium, a parenteral cephalosporin antibiotic, exerts its bactericidal action through inhibition of bacterial cell wall synthesis. Chemical structure modifications have enabled this compound to be resistant to the action of Richmond I, III, IV, and V β‐lactamase enzymes. Excellent activity against many gram‐negative bacilli, especially Enterobacteriaceae, has been demonstrated. Antipseudomonal activity is generally poor, however. Activity against gram‐positive cocci, with the notable exception of Streptococcus fecalis, is adequate. Anaerobic activity is variable, particularly against Clostridia and Bacteroides species.Acute, subacute, and chronic toxicity studies in animals were generally unremarkable. No mutagenic effects or reproductive toxicity have been noted in animals.In man, cefotaxime is desacetylated to a microbiologically active metabolite. Urinary excretion is approximately 50–60% and 15–20% of a dose for the parent compound and desacetyl metabolite, respectively. The elimination half‐life of cefotaxime is about one hour, with the total body clearance being approximately twice that of the renal clearance. Severe renal dysfunction causes a prolongation of the elimination half‐life of cefotaxime and particularly desacetyl cefotaxime. A relatively low degree of protein binding in part attributes to a wide bodily distribution of cefotaxime.Cefotaxime is effective in a variety of infectious processes caused by susceptible organisms. Local reactions at the injection site and hypersensitivity phenomena are the most common adverse effects. Comparative trials attesting to cefotaxime's clinical utility over other parenteral cephalosporins or aminoglycosides are very limited.Based on the available evidence, cefotaxime should be most useful in combating serious gram‐negative infections, because of its excellent activity against most of these organisms and its low toxicity profile.