bluuebunny/crossref_metadata_2025_split huggingface dataset:
Affective experience of physical user interfaces: Similarities and differences among control types
Authors: Rhiu Ilsun , Bahn Sangwoo , Nam Chang S. , Yun Myung Hwan 
Published: September 2017

AbstractThis study aims to determine similarities and differences in affective experience when manipulating 3 physical user interfaces (PUIs): button, touch screen, and jog dial inputs. First, we conducted literature and expert reviews to identify key affective experiences of PUI manipulation. As a result, seven affective experiences (Softness, Elasticity, Heaviness, Smoothness, Sharpness, Clarity of Feedback, and Rattle) were identified, and they were categorized into two dimensions (Force and Feedback Vibration). Three experiments, including 51 types of buttons, 25 synthesized stimuli for touch screen, and 51 types of jog dials, were then conducted to determine the relationship between affective experiences, satisfaction, and physical parameters of each PUI. According to the results, it was common for all three PUIs that Clarity of Feedback was the most important factor for satisfaction. However, there were also differences between the effects of affective experiences and physical parameters. User satisfaction on manipulating jog dials was found to be less affected by affective experiences than buttons and touch screens. Among physical parameters, the strength of feedback was the most important factor for the affective experience of buttons and touch screens, whereas the period of feedback was the most important factor for jog dials. These similarities and differences could be explained by cognitive and manipulative factors (e.g., attention level, types of feedback, and hand posture of manipulation). The results of this study can help researchers and practitioners better understand and enhance the affective aspects of PUI manipulations.
How toddlers' irritability and fearfulness relate to parenting: A longitudinal study conducted among Quebec families
Authors: Armour Jessie‐Ann , Joussemet Mireille , Kurdi Vanessa , Tessier Jeanne , Boivin Michel , Tremblay Richard E. 
Published: September 2017

AbstractAlthough child difficult temperament is a well‐known risk factor for parenting quality, few studies have focused on the association between specific temperament dimensions and parental behaviours. This study focused on negative emotionality, one of the best‐accepted dimensions of temperament, and its subdimensions of irritability and fearfulness. The aim of the present study was to evaluate the predictive value of irritability and fearfulness at 17 months upon parenting practices (involvement, coercion, and overprotection) at 29 months, beyond the influence of other well‐known risk factors (e.g., socio‐economic status and maternal depression). The study used data from the Quebec Longitudinal Study of Child Development, a longitudinal study conducted upon 1,829 families from Quebec (Canada), using self‐report questionnaires and medical files. Structural equation modelling identified irritability as a predictor of coercion, an externally controlling practice, whereas fearfulness predicted overprotection, an internally controlling practice. No significant associations were found after modelling between dimensions of negative emotionality and involvement. These results underline how certain aspects of child temperament may differentially “pull for control” and lead parents to act in a certain way, which may thwart young children's development and need for autonomy.Highlights

This article investigates the associations between negative emotionality (i.e., irritability and fearfulness) and parenting (i.e., involvement, coercion, and overprotection).
Structural equation modelling was used on data collected during a longitudinal study with a representative sample of 2,223 families.
Each dimension of negative emotionality was associated to a different form of controlling parenting 1 year later (i.e., irritability with coercion and fearfulness with overprotection).
Impact of maternal weight on the intra‐observer and inter‐observer reproducibility of fetal ultrasonography measurements in the third trimester
Authors: Policiano Catarina , Mendes Jorge M. , Fonseca Andreia , Barros Joana , Martins Diana , Reis Inês , Clode Nuno , Graça Luís M. 
Published: September 2017

AbstractObjectiveTo evaluate the effect of maternal weight on the intra‐ and inter‐observer reproducibility of third‐trimester ultrasonography fetal measurements.MethodsThe present prospective study, performed at a tertiary hospital, enrolled patients at between 35+0 weeks and 36+6 weeks of singleton pregnancies between January 1, 2015, and July 1, 2016. Fetal ultrasonography measurements were evaluated twice by a first observer and a third time by a second observer. Intra‐ and inter‐observer consistency were analyzed using the Cronbach α reliability coefficient, and measurement reproducibility was compared with patients stratified by a body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) of below 25 or at least 25.ResultsThe study included 197 patients (133 with BMI <25 and 64 with BMI ≥25). Among patients with a BMI below 25, the reliability coefficients for bi‐parietal diameter, head circumference, abdominal circumference, and femur length measurements were 0.97, 0.95, 0.98, and 0.96, respectively, for intra‐observer consistency, and were 0.97, 0.93, 0.98, and 0.95, respectively, for inter‐observer consistency. Among patients with a BMI of at least 25, these values were 0.97, 0.96, 0.98, and 0.97, respectively, for intra‐observed consistency, and 0.97, 0.94, 0.98, and 0.96, respectively, for inter‐observer consistency.ConclusionHigh intra‐ and inter‐observer reproducibility was observed for third‐trimester fetal ultrasonography measurements, including for patients who were overweight.
A practical approach to assess inhalation toxicity of metal oxide nanoparticles in vitro
Authors: Dankers Anita C. A. , Kuper C. Frieke , Boumeester Anja J. , Fabriek Babs O. , Kooter Ingeborg M. , Gröllers‐Mulderij Mariska , Tromp Peter , Nelissen Inge , Zondervan‐Van Den Beuken Esther K. , Vandebriel Rob J. 
Published: September 2017

AbstractExposure of humans to metal oxide nanoparticles (NPs) occurs mainly via air, and inhaled metal oxide NPs may generate inflammation. The aim of this study was to investigate the proinflammatory potential of six metal oxide NPs (CeO2, Mn2O3, CuO, ZnO, Co3O4 and WO3; 27–108 μg ml−1) using human primary 3‐dimensional airway epithelium (MucilAir™) and dendritic cell (DC) models. Metal oxide NPs were mainly aggregated/agglomerated in the cell media, as determined by dynamic light scattering, scanning electron microscopy and differential centrifugal sedimentation. WO3 and ZnO were highly soluble, both with and without respiratory mucus. Proinflammatory signalling by the epithelium was evaluated after a 24 hour exposure by increased interleukin‐6 and ‐8 and monocyte chemoattractant protein 1 cytokine release, which occurred only for CuO. Moreover, maturation of immature human DCs, which play a key role in the lung immune system, were evaluated by expression of surface markers HLA‐DR, CD80, CD83 and CD86 after a 48 hour exposure. Only Mn2O3 consistently upregulated DC maturation markers. Furthermore, by addition of medium from metal oxide NP‐exposed 3‐dimensional airway cultures to metal oxide NP‐exposed DC cultures, the interplay between lung epithelium and DCs was studied. Such an interplay was again only observed for Mn2O3 and in one of five DC donors. Our results show that, even when using dosages that represent very high in vivo exposure levels, up to 27 hours of constant human airway exposure, metal oxide NPs cause minimal proinflammatory effects and that epithelial cells not necessarily interfere with DC maturation upon metal oxide NP exposure. The present approach exemplifies a relevant translation towards human safety assessment.
A preliminary in vitro evaluation of the bioactive potential of cryogel scaffolds incorporated with Manuka honey for the treatment of chronic bone infections
Authors: Hixon Katherine R. , Lu Tracy , Carletta Marissa N. , McBride‐Gagyi Sarah H. , Janowiak Blythe E. , Sell Scott A. 
Published: September 2017

AbstractPrevious studies have identified honey as an agent in bacterial inhibition and a mediator in lowering the pH at the wound site. Manuka honey (MH), indigenous to New Zealand, contains a Unique Manuka Factor that provides an additional antibacterial agent. While there are many potential benefits to incorporating MH into wounds, there is currently no ideal way to deliver the material to the site of injury. Cryogels are a type of scaffold that possess high porosity, mechanical stability, and a sponge‐like consistency. This study uniquely incorporates varying amounts of MH into cryogel scaffolds, utilizing its properties in a sustained release fashion to assist in the overall healing process, while using the cryogel structure as a tissue template. All cryogels were evaluated to determine the effects of MH on porosity, swelling potential, mechanical durability, and cell compatibility. The release of MH was also quantified to evaluate bacterial clearance potential, and the scaffolds were mineralized to replicate native bone. It was determined that a 5% MH silk fibroin cryogel has the potential to inhibit bacterial growth while still maintaining adequate porosity, mechanical properties, and cell infiltration. Such a scaffold would have use in a number of applications, including bone regeneration. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1918–1933, 2018.
Association of Lp‐PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population
Authors: Ni Jing , Gu Hong , Hu Wuhao , Zhou Fang , Zhu Xue , Wang Ke 
Published: September 2017

AbstractThe association between lipoprotein‐associated phospholipase A2 (Lp‐PLA2) G994T gene polymorphism and the risk of ischemic stroke is unclear. The aim of this study is to investigate the influence of Lp‐PLA2 G994T genetic variant on the pathogenesis of ischemic stroke in Chinese population. A total of 348 patients with a clinical diagnosis of ischemic stroke and 260 gender‐matched control subjects under physical examination were recruited from hospitals and genotyped for G994T gene polymorphism. The results showed that there was a significant difference in the genotype distribution between the two groups and people with GT or TT genotype were associated with the higher risk of ischemic stroke even after adjusting the effects of potential confounding factors. In addition, both ischemic stroke patients and control subjects carrying T allele showed relatively lower Lp‐PLA2 activity and higher oxLDL level. Therefore, Lp‐PLA2 G994T gene polymorphism may be an independent risk factor of ischemic stroke in Chinese population.
Sequence and timing of early cranial skeletal development in Xenopus laevis
Authors: Lukas Paul , Olsson Lennart 
Published: September 2017

AbstractXenopus laevis is widely used as a model organism in biological research. Morphological descriptions of the larval cartilaginous skeleton are more than half a century old and comprehensive studies of early cartilage differentiation and development are missing. A proper understanding of early cranial skeletal development in X. laevis requires a detailed description that can function as a baseline for experimental studies. This basis makes it possible to evaluate skeletal defects produced by experiments on gene interactions, such as gain‐ or loss‐of function experiments. In this study, we provide a detailed description of the pattern and timing of early cartilage differentiation and development in the larval head of X. laevis. Methods used include antibody staining, confocal laser scanning microscopy and 3D‐reconstruction. Results were than compared to earlier studies based on classical histological approaches and clearing‐and‐staining. The first cartilage to chondrify is, in contrast to other vertebrates investigated so far, the ceratohyal. The components of the branchial basket chondrify in anterior‐to‐posterior direction as reported for other amphibians. Chondrification of different cartilages begins at different stages and the majority of cartilages are fully developed at Ziermann and Olsson stage 17. Our baseline data on the pattern and timing of early cartilaginous development in X. laevis is useful for evaluation of experiments which alter head skeletal development as well as for identifying heterochronic shifts in head development in other amphibians.
Palovarotene inhibits connective tissue progenitor cell proliferation in a rat model of combat‐related heterotopic ossification
Authors: Wheatley Benjamin M. , Cilwa Katherine E. , Dey Devaveena , Qureshi Ammar T. , Seavey Jonathan G. , Tomasino Allison M. , Sanders Erin M. , Bova Wesley , Boehm Cynthia A. , Iwamoto Masahiro , Potter Benjamin K. , Forsberg Jonathan A. , Muschler George F. , Davis Thomas A. 
Published: September 2017

ABSTRACTHeterotopic ossification (HO) develops in the extremities of wounded service members and is common in the setting of high‐energy penetrating injuries and blast‐related amputations. No safe and effective prophylaxis modality has been identified for this patient population. Palovarotene has been shown to reduce bone formation in traumatic and genetic models of HO. The purpose of this study was to determine the effects of Palovarotene on inflammation, progenitor cell proliferation, and gene expression following a blast‐related amputation in a rodent model (n = 72 animals), as well as the ability of Raman spectroscopy to detect early HO before radiographic changes are present. Treatment with Palovarotene was found to dampen the systemic inflammatory response including the cytokines IL‐6 (p = 0.01), TNF‐α (p = 0.001), and IFN‐γ (p = 0.03) as well as the local inflammatory response via a 76% reduction in the cellular infiltration at post‐operative day (POD)‐7 (p = 0.03). Palovarotene decreased osteogenic connective tissue progenitor (CTP‐O) colonies by as much as 98% both in vitro (p = 0.04) and in vivo (p = 0.01). Palovarotene treated animals exhibited significantly decreased expression of osteo‐ and chondrogenic genes by POD‐7, including BMP4 (p = 0.02). Finally, Raman spectroscopy was able to detect differences between the two groups by POD‐1 (p < 0.001). These results indicate that Palovarotene inhibits traumatic HO formation through multiple inter‐related mechanisms including anti‐inflammatory, anti‐proliferative, and gene expression modulation. Further, that Raman spectroscopy is able to detect markers of early HO formation before it becomes radiographically evident, which could facilitate earlier diagnosis and treatment. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1135–1144, 2018.
BIO alleviated compressive mechanical force‐mediated mandibular cartilage pathological changes through Wnt/β‐catenin signaling activation
Authors: Jiang Yuan‐Yuan , Wen Juan , Gong Cheng , Lin Shuang , Zhang Cai Xia , Chen Sheng , Cheng Wei , Li Huang 
Published: September 2017

ABSTRACTOsteoarthritis induced by compressive mechanical force is characterized by decreased chondrocyte proliferation and degradation of the ECM. To examine underlying mechanisms of the pathological changes of mandibular cartilage induced by compressive mechanical force, an established animal model was used to examine Wnt signaling activation by glycogen synthase kinase‐3 beta (GSK3β) inhibitor 6‐Bromoindirubin‐3′‐oxime (BIO) injection in vivo. Histological changes in mandibular cartilage were assessed via hematoxylin & eosin (HE), masson, and alcian blue staining. Immunohistochemistry and real‐time PCR were performed to evaluate activation of the Wnt signaling pathway and chondrocytes proliferation markers. Chondrocytes apoptosis was examined by TUNEL staining. During the compressive mechanical force loading‐mediated process, Wnt signaling was largely inhibited, which showed the inhibited expression of β‐catenin and the increased expression of GSK‐3β. The expression of chondrocytes proliferation markers Ki67, and proliferating cell nuclear antigen (PCNA) also decreased. With BIO injection, the Wnt signaling was restored and the proliferation of mandibular chondrocytes was also increased in the late stage (7 days) of compressive mechanical force loading. Finally, the decreasing mandibular cartilage thickness, the degradation of extracellular matrix, and the erosion of bone trabecula were subsequently restored. Also, the changes of extracellular matrix markers such as collagen II and collagen X, matrix metalloproteases, and inflammatory cytokines were reversed followed by the injection of BIO. In summary, compressive mechanical force decreased endogenously Wnt signaling, leading to impaired proliferation in chondrocytes and degradation in cartilage matrix. Restoration of Wnt signaling largely recovered the proliferation defects and alleviated the pathological changes of mandibular cartilage. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1228–1237, 2018.
In vitro loading models for tendon mechanobiology
Authors: Wang Tao , Chen Peilin , Zheng Monica , Wang Allan , Lloyd David , Leys Toby , Zheng Qiujian , Zheng Ming H. 
Published: September 2017

ABSTRACTTendons are the connective tissue responsible for transferring force from muscles to bones. A key factor in tendon development, maturation, repair, and degradation is its biomechanical environment. Understanding tendon mechanobiology is essential for the development of injury prevention strategies, rehabilitation protocols and potentially novel treatments in tendon injury and degeneration. Despite the simple overall loading on tendon tissue, cells within the tissue in vivo experience a much more complex mechanical environment including tension, compression and shear forces. This creates a substantial challenge in the establishment of in vitro loading models of the tendon. This article reviews multiple loading models used for the study of tendon mechanobiology and summarizes the main findings. Although impressive progress has been achieved in the functionality and mimicry of in vitro loading models, an ideal platform is yet to be developed. Multidisciplinary approaches and collaborations will be the key to unveiling the tendon mechanobiology. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:566–575, 2018.
Flooding history of Lake Nakaumi, western Japan, inferred from sediment records spanning the past 700 years
Authors: Ota Yuki , Kawahata Hodaka , Sato Takaharu , Seto Koji 
Published: September 2017

ABSTRACTManagement of flood risk can benefit from a knowledge‐based approach to flooding history. However, the data on such events are often insufficient for an objective evaluation of flooding characteristics such as their intensity. Therefore, we analyzed a 14C‐dated sediment core recovered from near the Iinashi River mouth in Lake Nakaumi, western Japan, and reconstructed flooding records over the past 700 years from rock magnetism, grain‐size distribution and sediment geochemistry. The sediment core contained three black layers, characterized by high magnetic susceptibility, low anhysteretic remanent magnetization to saturation isothermal remanent magnetization ratio, high total organic carbon (TOC) to total nitrogen ratio, and coarse mean grain size, which we identified as possible flooding event deposits. Moreover, the chemical index of alteration was low and the TOC to total sulfur ratio was high in these layers, indicating intensified erosion associated with more freshwater inflow due to the flood events. We tentatively correlated the three event deposits with historical floods along the Iinashi River in AD 1596, 1666 and 1826. The variations in rock magnetic and geochemical properties suggest that the flooding in AD 1666 may have been the least extreme of the events detected in the core.
Raman spectroscopy of methane (CH4) to 165 GPa: Effect of structural changes on Raman spectra
Authors: Proctor J.E. , Maynard‐Casely H.E. , Hakeem M.A. , Cantiah D. 
Published: September 2017

AbstractWe have conducted a Raman study of methane (CH4), a major constituent of the outer planets, at pressures up to 165 GPa. We observe splitting of the principal Raman‐active vibrational mode above 45 GPa and a nonlinear dependence of Raman peak position on pressure. A discontinuous change in the pressure derivative of the ν3 peak position is observed at approximately 75 GPa, corresponding to the phase change previously observed using X‐ray diffraction. The Grüneisen parameters for the principal Raman‐active modes of methane in the simple cubic and high‐pressure cubic phases are calculated. The predicted dissociation of methane at ultrahigh pressure to form C2H6 and H2 is not observed, but an additional discontinuous change in the pressure‐induced shift of the Raman peaks is observed at 110 GPa. We suggest that this may be due to some reorientation or reordering of the methane molecules within the framework of the known cubic lattice.
Through barrier detection of ethanol using handheld Raman spectroscopy—Conventional Raman versus spatially offset Raman spectroscopy (SORS)
Authors: Nicolson Fay , Jamieson Lauren E. , Mabbott Samuel , Shand Neil C. , Graham Duncan , Faulds Karen 
Published: September 2017

AbstractSpatially offset Raman spectroscopy (SORS) provides chemical analysis at depth even when obscuring barriers such as plastic or tissue are present. As the collection probe is moved further away from the point of laser excitation, scattered photons from deeper layers begin to dominate the acquired spectra, thus giving rise to through barrier detection. Here, we demonstrate the potential of conventional Raman (CR) and SORS for through barrier detection using handheld spectrometers. We report the collection of Raman signals from an ethanol solution through plastic at thicknesses of up to 21 mm using SORS in combination with multivariate analysis. SORS is compared to CR, where we also demonstrate impressive through barrier detection of ethanol at depths up to 9 mm. We also highlight the advantage of applying multivariate analysis for through barrier detection using CR or SORS, particularly when peaks with similar spectral features are present in both the barrier and analyte spectra. In addition, to the best of our knowledge, this is the first report of the assessment of the maximum level of through barrier detection using handheld CR and SORS instruments with a backscattering geometry.
Polarized Raman scattering on single crystals of rare earth orthochromite RCrO3 (R = La, Pr, Nd, and Sm)
Authors: Camara Nimbo Robert , Ta Phuoc Vinh , Monot‐Laffez Isabelle , Zaghrioui Mustapha 
Published: September 2017

AbstractWe report on polarized Raman scattering on orthorhombic RCrO3 (R = La, Pr, Nd, and Sm) single crystals at room temperature. The analysis of polarized Raman spectra as a function of polarizer and analyzer angles with respect to crystallographic axes allowed to observe in these flux grown crystals phonon modes that were not detected yet. On the basis of both Raman selection rules and lattice dynamics calculations within density functional perturbations theory framework, the observed Ag, B1g, B2g, and B3g phonon modes were unambiguously assigned. Phonon mode wave number evolutions as a function of orthorhombic distortion, related to rare earth ionic radius, were investigated and highlighted a complex behavior for several low wave number modes allowed crossing. For the modes of same symmetry, a mode mixing behavior is observed, and numerical calculations based on two or three coupling systems were performed to fit experimental data and to extract the coupling constants.