bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nasal high-flow therapy reduces work of breathing compared with oxygen during sleep in COPD and smoking controls: a prospective observational study
Authors: Biselli Paolo J. C. , Kirkness Jason P. , Grote Ludger , Fricke Kathrin , Schwartz Alan R. , Smith Philip , Schneider Hartmut 
Published: November 2016

Patients with chronic obstructive pulmonary disease (COPD) endure excessive resistive and elastic loads leading to chronic respiratory failure. Oxygen supplementation corrects hypoxemia but is not expected to reduce mechanical loads. Nasal high-flow (NHF) therapy supports breathing by reducing dead space, but it is unclear how it affects mechanical loads of patients with COPD. The objective of this study was to compare the effects of low-flow oxygen and NHF therapy on ventilation and work of breathing (WOB) in patients with COPD and controls during sleep. Patients with COPD ( n = 12) and controls ( n = 6) were recruited and submitted to polysomnography to measure sleep parameters and ventilation in response to administration of oxygen and NHF. A subset of six patients also had an esophageal catheter inserted for the purpose of measuring WOB. Patients with COPD had similar minute ventilation (V̇e) but lower tidal volumes than matched controls. With oxygen, [Formula: see text]was increased and V̇e was reduced in both controls and patients with COPD, but there was an increase in transcutaneous CO2 levels. NHF produced a greater reduction in V̇e and was associated with a reduction in CO2 levels. Although NHF halved WOB, oxygen produced only a minor reduction in this parameter. We conclude that oxygen produced little change in WOB, which was associated with CO2 elevations. On the other hand, NHF produced a large reduction in V̇e and WOB with a concomitant decrease in CO2 levels. Our data indicate that NHF improves alveolar ventilation during sleep compared with oxygen and room air in patients with COPD and therefore can decrease their cost of breathing. NEW & NOTEWORTHY Nasal high-flow (NHF) therapy can support ventilation in patients with chronic obstructive pulmonary disease during sleep by decreasing the work of breathing and improving CO2 levels. On the other hand, oxygen supplementation corrects hypoxemia, but it produces only a minimal reduction in work of breathing and is associated with increased CO2 levels. Therefore, NHF can be a useful method to assist ventilation in patients with increased respiratory mechanical loads.
MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer
Authors: Oudin Madeleine J. , Barbier Lucie , Schäfer Claudia , Kosciuk Tatsiana , Miller Miles A. , Han Sangyoon , Jonas Oliver , Lauffenburger Douglas A. , Gertler Frank B. 
Published: November 2016

Abstract
Taxane therapy remains the standard of care for triple-negative breast cancer. However, high frequencies of recurrence and progression in treated patients indicate that metastatic breast cancer cells can acquire resistance to this drug. The actin regulatory protein MENA and particularly its invasive isoform, MENAINV, are established drivers of metastasis. MENAINV expression is significantly correlated with metastasis and poor outcome in human patients with breast cancer. We investigated whether MENA isoforms might play a role in driving resistance to chemotherapeutics. We find that both MENA and MENAINV confer resistance to the taxane paclitaxel, but not to the widely used DNA-damaging agents doxorubicin or cisplatin. Furthermore, paclitaxel treatment does not attenuate growth of MENAINV-driven metastatic lesions. Mechanistically, MENA isoform expression alters the ratio of dynamic and stable microtubule populations in paclitaxel-treated cells. MENA expression also increases MAPK signaling in response to paclitaxel treatment. Decreasing ERK phosphorylation by co-treatment with MEK inhibitor restored paclitaxel sensitivity by driving microtubule stabilization in MENA isoform–expressing cells. Our results reveal a novel mechanism of taxane resistance in highly metastatic breast cancer cells and identify a combination therapy to overcome such resistance. Mol Cancer Ther; 16(1); 143–55. ©2016 AACR.
Dual Endothelin-A/Endothelin-B Receptor Blockade and Cardiac Remodeling in Heart Failure With Preserved Ejection Fraction
Authors: Valero-Munoz Maria , Li Shanpeng , Wilson Richard M. , Boldbaatar Batbold , Iglarz Marc , Sam Flora 
Published: November 2016

Background—
Despite the increasing prevalence of heart failure with preserved ejection fraction (HFpEF) in humans, there remains no evidence-based therapies for HFpEF. Endothelin-1 (ET-1) antagonists are a possibility because elevated ET-1 levels are associated with adverse cardiovascular effects, such as arterial and pulmonary vasoconstriction, impaired left ventricular (LV) relaxation, and stimulation of LV hypertrophy. LV hypertrophy is a common phenotype in HFpEF, particularly when associated with hypertension.

Methods and Results—
In the present study, we found that ET-1 levels were significantly elevated in patients with chronic stable HFpEF. We then sought to investigate the effects of chronic macitentan, a dual ET-A/ET-B receptor antagonist, on cardiac structure and function in a murine model of HFpEF induced by chronic aldosterone infusion. Macitentan caused LV hypertrophy regression independent of blood pressure changes in HFpEF. Although macitentan did not modulate diastolic dysfunction in HFpEF, it significantly reduced wall thickness and relative wall thickness after 2 weeks of therapy. In vitro studies showed that macitentan decreased the aldosterone-induced cardiomyocyte hypertrophy. These changes were mediated by a reduction in the expression of cardiac myocyte enhancer factor 2a. Moreover, macitentan improved adverse cardiac remodeling, by reducing the stiffer cardiac collagen I and titin n2b expression in the left ventricle of mice with HFpEF.

Conclusions—
These findings indicate that dual ET-A/ET-B receptor inhibition improves HFpEF by abrogating adverse cardiac remodeling via antihypertrophic mechanisms and by reducing stiffness. Additional studies are needed to explore the role of dual ET-1 receptor antagonists in patients with HFpEF.
Crustacean zooplankton assemblages in Algerian saline lakes: a comparison with their Chilean Altiplano counterparts
Authors: De los Ríos-Escalante Patricio , Amarouayache Mounia 
Published: November 2016

Crustacean communities in saline lakes are regulated mainly by salinity, and a significant inverse correlation can be found between salinity and species richness. The aim of the present study is to compare the carcinological diversity of two distinct arid regions of the world: Algerian saline lakes, locally called “chotts” and “sebkhas”, and their Chilean Altiplano counterparts, and to determine if there are similar regulator patterns that influence the composition of those communities. The main halophilic taxon common to both regions was the anostracan Artemia at high salinities. However, many other halotolerant crustaceans may occur in Algerian chotts and sebkhas, such as Phallocryptus spinosa, Branchinectella media, Moina salina, Cletocamptus retrogressus, Arctodiaptomus salinus and Heterocypris sp. In Chilean saline lakes the calanoid copepod Boeckella poopoensis was an important component of zooplankton at high salinities, while ostracods were totally absent. The results of correlation analysis revealed a significant inverse correlation between salinity and species number (Algeria, , , p-value = 0.0032; Chile, , ; p-value < 0.0165). The results of null model analysis describing species co-occurrence showed that the species communities are random for Algerian saline lakes due to the presence of many halotolerant species. For Chilean saline lakes, the species communities are structured.
The Vertical Structure of Low-Frequency Motions in the Nearshore. Part II: Theory
Authors: Lippmann Thomas C. , Bowen Anthony J. 
Published: November 2016

AbstractField observations from a vertical stack of two-component current meters obtained from the 1994 Duck94 nearshore field experiment (presented in a companion paper by Lippmann, et al.) show significant vertical structure in energy, phase, and rotation of motions at low frequencies around 0.005 Hz. Low-frequency motions are typically modeled in the surfzone with the shallow-water (depth averaged) momentum equations that do not allow for any vertical structure. Following work from the shelf tidal community (Prandle), this study shows that the observations are consistent with the depth-varying momentum equations including shear stresses induced by a bottom boundary layer described by a constant eddy viscosity νt and bottom friction given by a constant drag coefficient and depth-averaged velocity . The bidirectional flow field is solved over arbitrary depth profiles varying only in the cross-shore direction h(x) in the presence of a vertically uniform mean alongshore current with cross-shore shear structure V(x). Analytic solutions are found to depend on νt, cd, h, ∂V/∂x, and the parameter , where σ and k are the radian frequency and alongshore wavenumber of the oscillating motion. Model behavior is explored by plotting solutions for a given parameter space as functions of the nondimensional depth H = λh and dimensionless friction parameter that combines the effects of bottom drag and vertical mixing. The behavioral changes in amplitude, phase shift, and rotational structure over the water column are qualitatively similar to those observed in the field.
Deadly Tornadoes in Poland from 1820 to 2015
Authors: Taszarek Mateusz , Gromadzki Jakub 
Published: November 2016

Abstract
Using historical sources derived from 12 Polish digital libraries, an investigation into killer tornado events was carried out. Although some of the cases took place more than 150 years ago, it was still possible to identify tornado phenomena and the course of events. This study has shown that historical sources contain dozens of tornado reports, sometimes with information precise enough to reconstruct the tornado damage paths. In total, 26 newly identified deadly tornado cases were derived from the historical sources and the information on 11 currently known was expanded. An average of 1–2 killer tornadoes with 5 fatalities may be depicted for each decade and this rate is decreasing over time. It was estimated that 5%–10% of significant tornadoes in Poland have caused fatalities and the average number of fatalities per significant tornado was roughly 0.27. Most of the cases were reported in late July and early August. The majority of deaths and injuries were associated with victims being lifted or crushed by buildings (usually a wooden barn). Most of these cases took place in rural areas but some tornadoes hit urban areas, causing a higher number of fatalities. The spatial distribution of cases included maxima in the central lowland and south-central upland of Poland. In a noticeable fraction of cases (38%), large hail occurred either before or after passage of the tornado.
Assessing the Accuracy of Generalized Inferences From Comparison Group Studies Using a Within-Study Comparison Approach
Authors: Jaciw Andrew P. 
Published: November 2016

Background: Various studies have examined bias in impact estimates from comparison group studies (CGSs) of job training programs, and in education, where results are benchmarked against experimental results. Such within-study comparison (WSC) approaches investigate levels of bias in CGS-based impact estimates, as well as the success of various design and analytic strategies for reducing bias. Objectives: This article reviews past literature and summarizes conditions under which CGSs replicate experimental benchmark results. It extends the framework to, and develops the methodology for, situations where results from CGSs are generalized to untreated inference populations. Research design: Past research is summarized; methods are developed to examine bias in program impact estimates based on cross-site comparisons in a multisite trial that are evaluated against site-specific experimental benchmarks. Subjects: Students in Grades K–3 in 79 schools in Tennessee; students in Grades 4–8 in 82 schools in Alabama. Measures: Grades K–3 Stanford Achievement Test (SAT) in reading and math scores; Grades 4–8 SAT10 reading scores. Results: Past studies show that bias in CGS-based estimates can be limited through strong design, with local matching, and appropriate analysis involving pretest covariates and variables that represent selection processes. Extension of the methodology to investigate accuracy of generalized estimates from CGSs shows bias from confounders and effect moderators. Conclusion: CGS results, when extrapolated to untreated inference populations, may be biased due to variation in outcomes and impact. Accounting for effects of confounders or moderators may reduce bias.
Does Availability of Worksite Supports for Physical Activity Differ by Industry and Occupation?
Authors: Dodson Elizabeth A. , Hipp J. Aaron , Lee Jung Ae , Yang Lin , Marx Christine M. , Tabak Rachel G. , Brownson Ross C. 
Published: November 2016

Purpose: To explore combinations of worksite supports (WSS) for physical activity (PA) that may assist employees in meeting PA recommendations and to investigate how availability of WSS differs across industries and occupations. Design: Cross-sectional. Setting: Several Missouri metropolitan areas. Participants: Adults employed >20 h/wk outside the home. Measures: Survey utilized existing self-reported measures (eg, presence of WSS for PA) and the International Physical Activity Questionnaire. Analysis: Logistic regression was conducted for 2 outcome variables: leisure and transportation PA. Independent variables included 16 WSS. Of particular interest were interaction effects between WSS variables. Analyses were stratified by 5 occupation and 7 industry types. Results: Overall, 2013 people completed the survey (46% response rate). Often, availability of 1 WSS did not increase the likelihood of meeting PA recommendations, but several pairs of WSS did. For example, in business occupations, the odds of meeting PA recommendations through transportation PA increased when employees had access to showers and incentives to bike/walk (odds ratio [OR] = 1.6; 95% confidence interval [CI] = 1.16-2.22); showers and maps (OR = 1.25; 1.02-1.55); maps and incentives to bike/walk (OR = 1.48; 1.04-2.12). Conclusion: Various combinations of WSS may increase the likelihood that employees will meet PA recommendations. Many are of low or no cost, including flexible time for exercise and maps of worksite-adjacent walk/bike routes. Findings may be instructive for employers seeking to improve employee health through worksite PA.
Breast cancer incidence: Decreasing trend in large tumours in women aged 50–74
Authors: Molinié Florence , Delacour-Billon Solenne , Tretarre Brigitte , Delafosse Patricia , Seradour Brigitte , Colonna Marc 
Published: November 2016

Objective A decrease in advanced breast cancer incidence is considered an early indicator of breast cancer mortality reduction in a screening programme. We describe trends in breast cancer incidence according to tumour size and age in three French administrative areas, where an organized screening programme was implemented during the 1990s. Methods Our study included all 28,092 invasive breast cancers diagnosed from 2000 to 2010 in women living in three areas (Hérault, Isère, Loire-Atlantique). Age, year of diagnosis, and size of tumour at diagnosis was provided by the three area cancer registries. Poisson regression models were fitted to estimate changes in incidence over time, after adjustment for age and administrative area. Results From 2000 to 2010, the incidence rate of large (tumour size >20 mm) breast cancer linearly decreased in women aged 50–74 (target age of the screening programme) from 108.4 to 84.1/100,000 (annual percent change = −1.9%, p < 0.001). No change in large breast cancer incidence rate was found in women aged 20–49, or older than 74. Conclusions A decreasing trend in incidence of large tumour size breast cancer in the target age of the screening programme is demonstrated for the first time in France. The overall 20.9% linear decrease over 11 years in these three areas is encouraging and should be closely monitored and extended to other areas of France, where the screening programme was generally implemented only in 2004.
Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice
Authors: Morihara Hirofumi , Yamamoto Tsuyoshi , Oiwa Harunori , Tonegawa Kota , Tsuchiyama Daisuke , Kawakatsu Ikki , Obana Masanori , Maeda Makiko , Mohri Tomomi , Obika Satoshi , Fujio Yasushi , Nakayama Hiroyuki 
Published: November 2016

Background: Phospholamban (PLN) inhibition enhances calcium cycling and is a potential novel therapy for heart failure (HF). Antisense oligonucleotides (ASOs) are a promising tool for unmet medical needs. Nonviral vector use of locked nucleic acid (LNA)-modified ASOs (LNA-ASOs), which shows strong binding to target RNAs and is resistant to nuclease, is considered to have a potential for use in novel therapeutics in the next decades. Thus, the efficacy of a single-dose injection of LNA-ASO for cardiac disease needs to be elucidated. We assessed the therapeutic efficacy of a single-dose LNA-ASO injection targeting PLN in pressure overload-induced cardiac dysfunction. Methods and Results: Mice intravenously injected with Cy3-labeled LNA-ASO displayed Cy3 fluorescence in the liver and heart 24 hours after injection. Subsequently, male C57BL/6 mice were subjected to sham or transverse aortic constriction surgery; after 3 weeks, these were treated with PLN-targeting LNA-ASO (0.3 mg/kg) or scrambled LNA-ASO. Cardiac function was measured by echocardiography before and 1 week after injection. Phospholamban-targeting LNA-ASO treatment significantly improved fractional shortening (FS) by 6.5%, whereas administration of the scrambled LNA-ASO decreased FS by 4.0%. Conclusion: Our study revealed that a single-dose injection of PLN-targeting LNA-ASO improved contractility in pressure overload-induced cardiac dysfunction, suggesting that LNA-ASO is a promising tool for hypertensive HF treatment.
Blunt traumatic transection of the right common carotid artery
Authors: Jambhekar Amani , Maselli Amy , Lindborg Ryan , Bobka Thomas , Fahoum Bashar , Rucinski James 
Published: November 2016

Background Carotid injuries are infrequent following blunt traumatic injury but can have potentially devastating neurologic consequences. We present a case of a 31-year-old male with right common carotid transection after blunt trauma to the neck. Case report A 31-year-old male with no notable medical history presented as a trauma level one activation after riding his bicycle into an open car door causing a Zone II laceration of his right anterior neck. The patient was hemodynamically normal, had an intact airway and had no neurologic deficits on evaluation in the trauma bay. He underwent a computed tomography angiogram of his neck which revealed a focal dissection of the right common carotid artery causing a 70%–80% luminal narrowing suspicious for a grade II injury. The patient was taken to the operating room for exploration of his neck laceration. He was found to have a grade V injury with complete transection of the right common carotid artery through the intima and media with intact adventitia. The arterial injury was repaired with polytetrafluoroethylene interposition graft. Perioperatively, the patient was started on dual antiplatelet therapy. He recovered uneventfully without neurologic deficits. Conclusion Complete transection of the common carotid artery following blunt trauma is rarely reported. Based on a review of the literature regarding blunt carotid injuries, it is reasonable to repair such injuries with prosthetic graft followed by either systemic anticoagulation or dual antiplatelet therapy.
Delayed presentation of penetrating carotid injury: Two cases and a review of the literature
Authors: Jambhekar Amani , Maselli Amy , Lindborg Ryan , Bobka Thomas , Fahoum Bashar , D’Ayala Marcus , Rucinski James 
Published: November 2016

Background Carotid injuries secondary to a penetrating mechanism of trauma can present immediately, weeks, or even years after the initial injury. Although uncommon, these injuries are associated with significant morbidity and mortality. We present two cases of delayed presentation of carotid injury after penetrating neck trauma, both of which were managed surgically. Case report A 57-year-old male presented with a symptomatic left facial artery pseudoaneurysm two weeks after sustaining a Zone III laceration at angle of mandible. He underwent successful left neck exploration and repair of pseudoaneurysm with complete resolution of his symptoms post-operatively. A 33-year-old female with a history of penetrating right neck trauma repaired primarily 10 years prior in Russia presented with new onset left upper extremity weakness and tingling. Outpatient diagnostic workup revealed a right common carotid aneurysm which was repaired with a polytetrafluoroethylene interposition graft. The patient was discharged without residual neurologic deficits. She represented several years later with neurologic symptoms and an occluded graft. She underwent successful ligation of her graft and was discharged with complete resolution of her symptoms. Conclusion Penetrating carotid injuries can manifest in an immediate or delayed fashion. Computerized tomographic angiography appears to be an appropriate diagnostic tool. Once diagnosed, either endovascular or surgical repair may be valid treatment options.
No sex differences in long-term functional outcome after intracerebral hemorrhage
Authors: de Ridder Inger , Kuramatsu Joji , Gerner Stefan , Madžar Dominik , Lücking Hannes , Kloska Stefan , Dippel Diederik , Schwab Stefan , Huttner Hagen B. 
Published: November 2016

Background There is conflicting evidence about the influence of sex on outcome after spontaneous intracerebral hemorrhage (sICH) and the majority of the research focused on mortality and short-term outcome only. We investigated sex differences in long-term functional outcome after sICH. Methods We used data from a prospective hospital registry and included all consecutive patients with ICH admitted to our institution between January 2006 and July 2014. Functional outcome was assessed by modified Rankin Scale evaluated 3 and 12 months after ICH. We explored the influence of sex on long-term functional outcome using multivariable regression models and additionally by means of propensity score matching. Results We analyzed 823 patients, of whom 380 (46%) women. Women were on average three years older (p < 0.001), men had more often deep hematomas (p = 0.01). Unadjusted mortality rates were significantly increased in women at three months (42% vs. 35%; odds ratio (OR): 1.35; 95% confidence interval (CI): 1.02–1.80). After adjusting for baseline prognostic factors there were no differences between men and women in short- and long-term mortality (OR = 1.01; 95% CI = 0.66–1.54 and OR = 1.04; 95%CI = 0.69–1.57, respectively) and short- and long-term unfavorable outcome (OR = 1.02; 95%CI = 0.67–1.55 and OR = 0.96; 95% CI = 0.62–1.48, respectively). Conclusion We found no sex-related differences in long-term functional outcome in patients with sICH. The apparently worse functional outcome in women can be explained by differences in age.