bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolation and Structure Determination of New Antibacterial Peptide Curacomycin Based on Genome Mining
Authors: Kaweewan Issara , Komaki Hisayuki , Hemmi Hikaru , Kodani Shinya 
Published: September 2017

AbstractA new antibacterial cyclic peptide, named curacomycin (1), and its analogue dechlorocuracomycin (2) were isolated from Streptomyces curacoi (NBRC 12761T) and Streptomyces noursei (NBRC 15452T), respectively, by using genome mining. The chemical structures of these two peptides were determined by using a combination of MS (ESI) and NMR spectroscopy. The structure of compound 1 was determined to be a cyclic peptide that consisted of six amino acids, including: valine (Val), leucine (Leu), isoleucine (Ile), ornithine (Orn), β‐hydroxyasparagine (OHAsn), and 5‐chlorotryptophan (ClTrp). The NMR data of compound 2 were very similar to that of compound 1, which indicated that the structure of compound 2 was a dechlorinated analogue of compound 1. A comparison of the antimicrobial activities of these two peptides indicated that the presence of chlorine in compound 1 was critical for its antimicrobial activity. The proposed biosynthetic gene clusters for compounds 1 and 2 were found in the genome data of S. curacoi and S. noursei, respectively. The functions of the biosynthetic genes were considered by comparison of the two gene clusters.
Mapping the Inhospitable Landscapes of the Orkney Islands using RPAS
Authors: Hanus Kasper 
Published: September 2017

AbstractThis paper reports the outcome of the RPAS‐based prospection of four prehistoric and early historic sites on Mainland, Rousay and South Ronaldsay Islands of the Orkney archipelago (Northern Scotland). Application of RPAS (Remotely Piloted Aircraft System) improved the effectiveness and accuracy of the mapping of the archaeological landscape, comparing to the ground‐base survey. The paper presents the workflow used to obtain the low altitude images using RPAS and photogrammetric pipeline applied to create ortophotomaps and digital elevation models. Then the interpretation of mapped remnants at the sites of Brough of Deerness, Burrian, Hashwick and Burwick is discussed. Beside reporting the new datasets for the Orkney the author is clarifying the problem of surveying “the inhospitable” landscapes ‐ the areas that for different reasons might be difficult to access by survey using ground‐based methods. Therefore Remotely Piloted Aircraft Systems are advocated as a solution in such challenging conditions.
Near‐Infrared‐Emissive Amphiphilic BODIPY Assemblies Manipulated by Charge‐Transfer Interaction: From Nanofibers to Nanorods and Nanodisks
Authors: Yin Jia‐Fu , Hu Yi , Wang Huan , Jin Zhong , Zhang Yi , Kuang Gui‐Chao 
Published: September 2017

AbstractA novel near‐infrared (NIR)‐emissive amphiphilic BODIPY derivative, BBDP, was successfully prepared and thoroughly characterized. The photophysical properties in various organic solvents and THF/H2O mixtures with different fractions of water were investigated. BBDP self‐assembled into nanofibers in a water environment owing to its amphiphilic properties. Through charge‐transfer interactions, BBDP co‐assembled with a perylene bisimide derivative, PBI, and a viologen derivative, MV, to generate two superamphiphiles. These two superamphiphiles were able to aggregate in water media at appropriate concentrations. The BBDP–PBI charge‐transfer complex formed nanorods, whereas the BBDP–MV aggregates expressed a disk‐like morphology. This research paves the way for us to manipulate the morphology of dye assemblies.
Mexican case report of a never‐treated Laron syndrome patient evolving to metabolic syndrome, type 2 diabetes, and stroke
Authors: Castilla‐Cortazar Inma , Femat‐Roldán Giovana , Rodríguez‐Rivera Joel , Aguirre Gabriel A. , García‐Magariño Mariano , Martín‐Estal Irene , Espinosa Luis , Díaz‐Olachea Carlos 
Published: September 2017

Key Clinical MessageGlucose and lipid profile together with blood pressure should always be considered for low sera‐IGF‐1 patients. Even when adulthood is reached, IGF‐1 therapy in these patients should be pursued as metabolic and protective cellular effects could be triggered. Real incidence of growth hormone insensitivity is still to be uncovered.
Incarcerated giant uterine leiomyoma within an incisional hernia: a case report
Authors: Exarchos Georgios , Vlahos Nikolaos , Dellaportas Dionysios , Metaxa Linda , Theodosopoulos Theodosios 
Published: September 2017

Key Clinical MessageUterine leiomyomas presenting as incarcerated or strangulated hernias in surgical emergencies are extremely rare and should be considered in the differential diagnosis in patients with known uterine fibroids and an irreducible ventral abdominal wall hernia. Detailed history and multidisciplinary approach optimize the diagnosis and decision making toward surgical treatment.
Recurrent TransIent Perivascular Inflammation of the Carotid artery syndrome with temporary carotid plaque on ultrasonography: a case report
Authors: Takamura Akiteru , Hori Ariyuki 
Published: September 2017

Key Clinical MessageTransIent Perivascular Inflammation of the Carotid artery (TIPIC) syndrome is a rare syndrome with an unknown cause that is characterized by unilateral neck pain. Its existence as a pathological entity was controversial. We describe a 44‐year‐old male presenting with a 10‐day history of right neck pain diagnosed recurrent TIPIC syndrome with temporary carotid plaque followed by ultrasonography.
Acute drop of platelets in metastatic colon cancer
Authors: Ahmed Ahmed‐Tarig , Gupta Shweta 
Published: September 2017

Key Clinical MessageOxaliplatin is a platinum commonly used in the treatment of metastatic colon cancer. It can cause thrombocytopenia through different mechanism. Sudden isolated drop in platelets should raise the concern for oxaliplatin immune‐induced thrombocytopenia and abrupt discontinuation of the drug. Patients should not be rechallenged with oxaliplatin once diagnosis of OIIT is confirmed.
Improving the Structural Stability of Li‐Rich Layered Cathode Materials by Constructing an Antisite Defect Nanolayer through Polyanion Doping
Authors: Ma Leilei , Mao Lei , Zhao Xiaofeng , Lu Jianhao , Zhang Fan , Ding Pengchong , Chen Lizefang , Lian Fang 
Published: September 2017

AbstractTo mitigate the gradual phase transition and improve the structural stability of Li‐rich layered cathode materials, an antisite defect nanolayer (transition‐metal ions replacing Li+ in a Li slab) with a thickness of approximately 2 nm was induced on the surface of Li1.16(Ni0.25Mn0.75)0.84O2 by doping with boracic polyanions. It is found that the 2 and 3 mol % BO33−‐doped samples show excellent cycling stability with capacity retentions of 91.2 and 93.7 %, respectively, after 300 cycles at 0.5 C. More importantly, the BO33− doping restrains the decay of discharge voltage upon cycling and has the prospect to overcome the fatal drawback of Li‐rich layered oxides. The results demonstrate that the BO33− doping contributes to the generation of an antisite defect nanolayer on the surface, which hinders the formation of Li‐ion vacancies and the continued migration of more transition‐metal ions to the Li slab in a deep charging state. The antisite defect nanolayer clearly improves surface structural stability and inhibits the appearance of the amorphous domain in the bulk, which are favorable to maintain the facile lithium‐diffusion pathways during cycling and improve the capacity retention and rate capability.
Uncertainty evaluation and propagation for spectral measurements
Authors: Schmähling Franko , Wübbeler Gerd , Krüger Udo , Ruggaber Benjamin , Schmidt Franz , Taubert Richard D. , Sperling Armin , Elster Clemens 
Published: September 2017

AbstractThe measurement of the spectral power distribution (SPD) of a radiation source by array spectroradiometers is a technique that is widely used. In many applications, quantities that are derived from the SPD by a weighted integral over a wavelength interval are of interest. These integral quantities ought to be accompanied by a reliable uncertainty statement, for example, to assess conformity with prescribed limits or in order to judge the consistency of results obtained at different laboratories. We have developed a generally applicable Monte Carlo procedure for evaluating the uncertainty of spectral measurements. The procedure naturally accounts for correlations in the SPD which turn out to be crucial. Means are provided to handle and transfer these large‐scale correlation matrices easily. The proposed approach is illustrated by the determination of the SPD of colored LEDs from array spectroradiometer measurements, together with the derived CIE 1931 color coordinates. MATLABTM software implementing the proposed analysis procedure is made available.
Evaluating a formal methodology for dynamic tuning of large‐scale parallel applications
Authors: Martínez Andrea , Sikora Anna , César Eduardo , Sorribes Joan 
Published: September 2017

SummaryLarge‐scale parallel applications performance is usually far from the expected. Dynamic tuning is a powerful technique that helps to improve the performance of parallel applications. To bring this technique to large‐scale computers, this work presents a model that enables decentralized dynamic tuning of large‐scale parallel applications. In this model, applications are decomposed into disjoint subsets of tasks that can be tuned individually but also abstracted to obtain a global view of the parallel application. The proposed model has been designed as a hierarchical tuning network of distributed analysis modules and implemented in the form of ELASTIC, an environment for large‐scale dynamic tuning. Using ELASTIC an experimental evaluation has been conducted over a synthetic large‐scale parallel application and a real agent‐based parallel application. The results show that the proposed model, embodied in ELASTIC, is able to scale to meet the demands of dynamic tuning over thousands of processes, while effectively improving the performance of large‐scale applications.
Children's psychosocial functioning and parents' quality of life in paediatric short stature: The mediating role of caregiving stress
Authors: Silva Neuza , Bullinger Monika , Sommer Rachel , Rohenkohl Anja , Witt Stefanie , Quitmann Julia 
Published: September 2017

ObjectivesOn the basis of the multidimensional model of the caregiving process, this study aimed (a) to compare the levels of quality of life (QoL) and psychological problems of children with short stature and the levels of caregiving stress and QoL of their parents, between diagnostic, treatment, and current height deviation groups, and (b) to examine the direct and indirect links, via caregiving stress, between children's psychosocial functioning and their parents' QoL.MethodThe sample was collected in 5 European countries and comprised 238 dyads of 8‐ to 18‐year‐old children and adolescents with a clinical diagnosis of growth hormone deficiency or idiopathic short stature and one of their parents. The children completed self‐report measures of height‐related QoL (Quality of Life in Short Stature Youth Core Module) and psychological problems (Strengths and Difficulties Questionnaire); the parents reported on their own QoL (EUROHIS‐QOL‐8 Index) and caregiving stress (Quality of Life in Short Stature Youth Effects on Parents subscale).ResultsChildren who were treated and who achieved normal height reported better QoL compared to those untreated and with current short stature. Parents of children with idiopathic short stature and current short stature presented greater caregiving stress than parents of children with growth hormone deficiency and achieved normal height. Children's better psychosocial functioning was indirectly associated with parents' better QoL, via less caregiving stress, and these links were invariant across diagnoses, treatment status, and current height deviation.ConclusionsThese results suggest that, along with growth hormone treatments, multidisciplinary interventions in paediatric endocrinology should be family‐centred, by targeting both the children's psychosocial functioning and the parents' stress, in order to improve individual and family adaptation.
Trading heat and hops for water: Dehydration effects on locomotor performance, thermal limits, and thermoregulatory behavior of a terrestrial toad
Authors: Anderson Rodolfo C. O. , Andrade Denis V. 
Published: September 2017

AbstractDue to their highly permeable skin and ectothermy, terrestrial amphibians are challenged by compromises between water balance and body temperature regulation. The way in which such compromises are accommodated, under a range of temperatures and dehydration levels, impacts importantly the behavior and ecology of amphibians. Thus, using the terrestrial toad Rhinella schneideri as a model organism, the goals of this study were twofold. First, we determined how the thermal sensitivity of a centrally relevant trait—locomotion—was affected by dehydration. Secondly, we examined the effects of the same levels of dehydration on thermal preference and thermal tolerance. As dehydration becomes more severe, the optimal temperature for locomotor performance was lowered and performance breadth narrower. Similarly, dehydration was accompanied by a decrease in the thermal tolerance range. Such a decrease was caused by both an increase in the critical minimal temperature and a decrease in the thermal maximal temperature, with the latter changing more markedly. In general, our results show that the negative effects of dehydration on behavioral performance and thermal tolerance are, at least partially, counteracted by concurrent adjustments in thermal preference. We discuss some of the potential implications of this observation for the conservation of anuran amphibians.
Acute kidney injury in cardiogenic shock: definitions, incidence, haemodynamic alterations, and mortality
Authors: Tarvasmäki Tuukka , Haapio Mikko , Mebazaa Alexandre , Sionis Alessandro , Silva‐Cardoso José , Tolppanen Heli , Lindholm Matias Greve , Pulkki Kari , Parissis John , Harjola Veli‐Pekka , Lassus Johan ,   on behalf of the CardShock Study Investigators
Published: September 2017

AimsTo investigate the incidence, haemodynamic alterations and 90‐day mortality of acute kidney injury (AKI) in patients with cardiogenic shock. We assessed the utility of creatinine, urine output (UO) and cystatin C (CysC) definitions of AKI in prognostication.Methods and resultsCardiogenic shock patients with serial plasma samples (n = 154) from the prospective multicenter CardShock study were included in the analysis. Acute kidney injury was defined and staged according to the KDIGO criteria by creatinine (AKIcrea) and/or UO (AKIUO). CysC‐based AKI (AKICysC) was defined similarly to AKIcrea. Changes in haemodynamic parameters were assessed over time from baseline until 96 h. Mean age of the study population was 66 ± 12 years and 74% were men. Median baseline creatinine was 1.12 [interquartile range (IQR) 0.87–1.54] mg/dL and CysC 1.19 (IQR 0.90–1.69) mg/L. The 90‐day mortality was 38%. The incidences for AKI were: AKIcrea 31%, AKIUO 50%, and AKICysc 33%. AKIcrea [odds ratio (OR) 12.2, 95% confidence interval (CI) 4.1–36.0] and AKICysC (OR 2.5, 95% CI 1.1–6.1), but not AKIUO, were independent predictors of mortality. However, a stricter UO cut‐off of <0.3 mL/kg/h for 6 h was independently associated with 90‐day mortality (OR 3.6, 95% CI 1.4–9.3). Development of AKI was associated with persistently elevated central venous pressure and decreased cardiac index and mean arterial pressure.ConclusionsAcute kidney injury is frequent in patients with cardiogenic shock and especially AKIcrea predicts poor outcome. The KDIGO UO criterion seems, however, rather liberal and a stricter AKI definition of UO <0.3 mL/kg/h for at least 6 h seems more useful for mortality risk prediction. Haemodynamic alterations reflecting venous congestion and hypoperfusion were associated with AKI.
Screening for heart transplantation and left ventricular assist system: results from the ScrEEning for advanced Heart Failure treatment (SEE‐HF) study
Authors: Lund Lars H. , Trochu Jean‐Noel , Meyns Bart , Caliskan Kadir , Shaw Steven , Schmitto Jan D. , Schibilsky David , Damme Laura , Heatley Jerry , Gustafsson Finn 
Published: September 2017

BackgroundHeart transplantation (HTx) and implantable left ventricular assist systems (LVAS) improve outcomes in advanced heart failure but may be underutilized. We hypothesized that screening can identify appropriate candidates.Methods and resultsThe ScrEEning for advanced Heart Failure treatment (SEE‐HF) study was a multicentre prospective study screening patients with existing cardiac resynchronization therapy (CRT) and/or implantable cardioverter‐defibrillator (ICD) for ejection fraction ≤40% and New York Heart Association (NYHA) class III–IV, and subsequently for guideline‐based HTx and LVAS indication. Of 1722 (mean age 64 ± 14 years, 26% women) patients screened at eight centres in seven European countries, 121 (7.0%) were eligible and 99 (5.7%; mean age 61 ± 10 years, 19% women) patients were enrolled for detailed assessment. Twenty‐six of the 99 enrolled patients (26%) were eligible for either HTx or LVAD (18 eligible for HTx; 7 eligible for LVAD; and 1 eligible for both). Eleven patients were listed for HTx and three received an LVAS. Eligible patients were 61 ± 8 years and 19% women, whereas those actually receiving intervention were 56 ± 8 years and 8% women.ConclusionsAmong patients with CRT and/or ICD, a minority have NYHA class III–IV heart failure and ejection fraction ≤40%. Among these, however, more than one‐quarter have an unrecognized need for HTx or LVAS. When patients are offered intervention based on screening, many decline. Discrepancies exist between clinical and patient equipoise.Clinical Trial Registration ClinicalTrials.gov Unique Identifier: NCT00894387
Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED‐HF study
Authors: Welsh Paul , Kou Lei , Yu Changhong , Anand Inder , van Veldhuisen Dirk J. , Maggioni Aldo P. , Desai Akshay S. , Solomon Scott D. , Pfeffer Marc A. , Cheng Sunfa , Gullestad Lars , Aukrust Pål , Ueland Thor , Swedberg Karl , Young James B. , Kattan Michael W. , Sattar Naveed , McMurray John J.V. 
Published: September 2017

AimsTo test the prognostic value of emerging biomarkers in the Reduction of Events by Darbepoetin Alfa in Heart Failure (RED‐HF) trial.Methods and resultsCirculating cardiac [N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), and high‐sensitivity troponin T (hsTnT)], neurohumoral [mid‐regional pro‐adrenomedullin (MR‐proADM) and copeptin], renal (cystatin C), and inflammatory [high‐sensitivity C‐reactive protein (hsCRP)] biomarkers were measured at randomization in 1853 participants with complete data. The relationship between these biomarkers and the primary composite endpoint of heart failure hospitalization or cardiovascular death over 28 months of follow‐up (n = 834) was evaluated using Cox proportional hazards regression, the c‐statistic and the net reclassification index (NRI). After adjustment, the hazard ratio (HR) for the composite outcome in the top tertile of the distribution compared to the lowest tertile for each biomarker was: NT‐proBNP 3.96 (95% CI 3.16–4.98), hsTnT 3.09 (95% CI 2.47–3.88), MR‐proADM 2.28 (95% CI 1.83–2.84), copeptin 1.66 (95% CI 1.35–2.04), cystatin C 1.92 (95% CI 1.55–2.37), and hsCRP 1.51 (95% CI 1.27–1.80). A basic clinical prediction model was improved on addition of each biomarker individually, most strongly by NT‐proBNP (NRI +62.3%, P < 0.001), but thereafter was only improved marginally by addition of hsTnT (NRI +33.1%, P = 0.004). Further addition of biomarkers did not improve discrimination further. Findings were similar for all‐cause mortality.ConclusionOnce NT‐proBNP is included, only hsTnT moderately further improved risk stratification in this group of chronic heart failure with reduced ejection fraction patients with moderate anaemia. NT‐proBNP and hsTnT far outperform other emerging biomarkers in prediction of adverse outcome.
Children with migraine: Provocation of headache via pressure to myofascial trigger points in the trapezius muscle? – A prospective controlled observational study
Authors: Landgraf M.N. , Biebl J.T. , Langhagen T. , Hannibal I. , Eggert T. , Vill K. , Gerstl L. , Albers L. , von Kries R. , Straube A. , Heinen F. 
Published: September 2017

AbstractBackgroundThe objective was to evaluate a supposed clinical interdependency of myofascial trigger points and migraine in children. Such interdependency would support an interaction of spinal and trigeminal afferences in the trigemino‐cervical complex as a contributing factor in migraine.MethodsChildren ≤18 years with the confirmed diagnosis of migraine were prospectively investigated. Comprehensive data on medical history, clinical neurological and psychological status were gathered. Trigger points in the trapezius muscle were identified by palpation and the threshold of pressure pain at these points was measured. Manual pressure was applied to the trigger points, and the occurrence and duration of induced headache were recorded. At a second consultation (4 weeks after the first), manual pressure with the detected pressure threshold was applied to non‐trigger points within the same trapezius muscle (control). Headache and related parameters were again recorded and compared to the results of the first consultation.ResultsA total of 13 girls and 13 boys with migraine and a median age of 14.5 (Range 6.3–17.8) years took part in the study. Manual pressure to trigger points in the trapezius muscle led to lasting headache after termination of the manual pressure in 13 patients while no patient experienced headache when manual pressure was applied to non‐trigger points at the control visit (p < 0.001). Headache was induced significantly more often in children ≥12 years and those with internalizing behavioural disorder.ConclusionWe found an association between trapezius muscle myofascial trigger points and migraine, which might underline the concept of the trigemino‐cervical complex, especially in adolescents.SignificanceIn children with migraine headache can often be induced by pressure to myofascial trigger points, but not by pressure to non‐trigger points in the trapezius muscle. This supports the hypothesis of a trigemino‐cervical‐complex in the pathophysiology of migraine, which might have implications for innovative therapies in children with migraine.
C‐reactive protein levels and treatment resistance in schizophrenia—A Danish population‐based cohort study
Authors: Horsdal Henriette Thisted , Wimberley Theresa , Benros Michael Eriksen , Gasse Christiane 
Published: September 2017

AbstractObjectiveSchizophrenia is associated with increased levels of inflammatory markers. However, it remains unclear whether inflammatory markers are associated with treatment‐resistant schizophrenia.MethodsWe conducted a population‐based follow‐up study among individuals with a first‐time schizophrenia diagnosis and a baseline C‐reactive protein measurement (a commonly available marker of systemic inflammation) from 2000 to 2012. We defined treatment resistance as the earliest observed instance of either clozapine initiation or hospital admission due to schizophrenia after having received at least 2 prior antipsychotic monotherapy trials of adequate duration. We used adjusted Cox regression analysis to calculate hazard ratios.ResultsWe identified 390 individuals with a C‐reactive protein measurement at first‐time schizophrenia diagnosis. A nonsignificant higher median C‐reactive protein (4.0 vs. 3.1 mg/L, p = .13) was observed among the 52 (13.3%) treatment‐resistant individuals. Increased levels of C‐reactive protein (above 3 mg/L) at baseline were not associated with treatment resistance (adjusted hazard ratio = 0.99, 95% confidence interval [0.56, 1.73]).ConclusionsC‐reactive protein, as a single inflammatory marker, appears insufficient to detect treatment‐resistant schizophrenia.