bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding end-of-life doula care provision: reporting on the design of a bereavement survey to evaluate doula support
Authors: Bashir Kirsten , Clare Emma , Pestano Catherine , Ramsey-Jones Esther , Borgstrom Erica 
Published: October 2024

Background: Delivery of consistent patient-centred care at end-of-life care continues to challenge healthcare providers and research continues to suggest that peoples’ needs are not being reliably met. Consequently, healthcare services are looking to innovate how support is provided, such as commissioning doulas to support dying people and those close to them. Objective: Within the United Kingdom, there is little existing research about peoples’ experience of receiving end-of-life doula support. This paper outlines the design of a survey for the family or friends of a person who received end-of-life doula support. Design: To evaluate the role of an end-of-life doula in supporting the dying person and those who care for them, we designed a post-bereavement survey as part of a wider evaluation strategy of doula services. Following multiple literature reviews and an iterative process of consulting with the professional organisation and previous service users, a questionnaire was developed to collect this data. This survey is hosted online, with paper copies available to widen accessibility. Conclusion: End-of-life doula support is a relatively new area of provision for dying people and those important to them, such as family and friends. It is even more innovative to have doula support commissioned as part of a locality’s healthcare service. There is a dire need for empirical research to understand the impact of this further. The process of researching the area and designing the evaluation survey for this service revealed the complexity of the role and the difficulty of capturing what was found to be helpful for the dying person and those around them.
The mineralogical composition of the zeolitic rocks of Santorini Island and their potential use as feed additives and nutrition supplements
Authors: Mytiglaki Christina , Kovaiou Soultana Kyriaki , Vogiatzis Dimitrios , Kantiranis Nikolaos , Filippidis Anestis 
Published: October 2024

AbstractThe zeolitic rocks of Akrotiri, on Santorini Island (Aegean Sea, Greece), can be grouped according to the zeolite minerals present. The first group includes zeolitic rocks that contain only clinoptilolite, the second group contains clinoptilolite and mordenite and the third group contains only mordenite. Clinoptilolite accounts for up to 56 wt.% and mordenite for up to 69 wt.% of the rocks. All samples contain feldspars (8–36 wt.%), clay minerals (6–8 wt.%), quartz (3–6 wt.%), opal-CT (2 wt.%), amphibole (2–4 wt.%) and amorphous materials (4–7 wt.%). The studied samples were classified chemically as andesites or dacites. The ammonium-exchange capacity of the studied samples was 104–158 meq 100 g–1. According to Commission Implementing Regulation (EU) No. 651/2013, zeolitic rocks that contain ≥80 wt.% clinoptilolite, ≤20 wt.% clay minerals and are free of fibrous minerals and quartz can be used as feed additives in animal husbandry. Zeolites with fibrous habit (mordenite, erionite, secondarily roggianite and mazzite) and SiO2 minerals such as quartz, cristobalite and tridymite can be dangerous to both humans and animals. The mineralogical study showed that, due to their low clinoptilolite content and the presence of both quartz and fibrous mordenite, the studied zeolitic rocks do not conform with European Regulation No. 651/2013. As a result, their use as feed additives and nutrition supplements is prohibited.
Induction of factor VIII tolerance by hemophilia gene transfer to eradicate factor VIII inhibitors
Authors: Young Guy 
Published: October 2024

Abstract
Patients with hemophilia A can develop antifactor antibodies to factor VIII. The incidence is ∼30%, and such patients suffer worse morbidity and mortality. The only proven method to eradicate these inhibitors is via immune tolerance induction therapy, which consists of infusing factor VIII concentrates at regular intervals. This approach is effective ∼65% of the time, leaving at least a third of patients who develop inhibitors with this lifelong problem. Although emicizumab has greatly improved the quality of life of inhibitor patients, eradicating the inhibitor remains an important treatment goal. Animal models have shown the potential for gene therapy to induce tolerance. A recent abstract describing a study in humans demonstrated the potential for successful tolerance induction. This article will describe the rationale for using gene therapy to induce tolerance and provide this author's viewpoint on the importance and possible historic significance of attempting to eradicate inhibitors with this approach.
Lower-intensity CPX-351 plus venetoclax induction for adults with newly diagnosed AML unfit for intensive chemotherapy
Authors: Uy Geoffrey L. , Pullarkat Vinod , Baratam Praneeth , Stuart Robert K. , Walter Roland B. , Winer Eric S. , Wang Qi , Faderl Stefan , Chakravarthy Divya , Menno Diane , Cheung Ronald S. , Lin Tara L. 
Published: October 2024

Abstract
Preclinical data suggest a rationale for combining CPX-351, a dual-drug liposomal encapsulation of daunorubicin and cytarabine, with venetoclax, a B-cell lymphoma-2 inhibitor. This phase 1b study evaluated lower-intensity CPX-351 combined with venetoclax in adults with acute myeloid leukemia (AML) considered unfit/ineligible for intensive chemotherapy. In a dose-exploration phase using a 3+3 design, patients received stepwise dosing of CPX-351 IV on days 1 and 3 plus venetoclax 400 mg orally on days 2 to 21 per cycle to determine the recommended phase 2 dose (RP2D) for this combination. During the expansion phase, additional patients received CPX-351 plus venetoclax at the identified RP2D. The primary end points were the RP2D and safety of CPX-351 combined with venetoclax. Secondary end points included preliminary efficacy and pharmacokinetics. Overall, 35 patients were enrolled in the study. A RP2D of CPX-351 30 units/m2 (daunorubicin 13.2 mg/m2 and cytarabine 30 mg/m2) plus venetoclax 400 mg was established. The safety profile of the combination was consistent with the known safety profiles of CPX-351 and venetoclax. Complete remission (CR)/CR with incomplete hematologic recovery (CRi) was achieved by 17 of 35 patients (49%), all after cycle 1; of these, 14 were negative for measurable residual disease. CR was achieved by 1 of 8 patients (13%) with a mutation in TP53, and CR/CRi was achieved by 15 of 26 patients (58%) with wild-type TP53. This study highlights that lower-intensity therapy of CPX-351 plus venetoclax as induction therapy provides a well-tolerated treatment option in adults with AML deemed unfit for intensive chemotherapy. This trial was registered at www.ClinicalTrials.gov as #NCT04038437.
Access barriers to anti-CD19+ CART therapy for NHL across a community transplant and cellular therapy network
Authors: Battiwalla Minoo , Tees Michael , Flinn Ian , Pantin Jeremy , Berdeja Jesus , Gregory Tara , Maris Michael , Bhushan Vikas , Vance Estil , Mathews John , Bachier Carlos , Shaughnessy Paul , Ramakrishnan Aravind , Malik Shahbaz , Mori Shahram , Martin Casey , Billups Rocky , Blunk Betsy , LeMaistre Charles F. , Majhail Navneet S. 
Published: October 2024

Abstract
We analyzed access barriers to anti-CD19+ chimeric antigen receptor T cells (CARTs) for non-Hodgkin lymphoma (NHL) within a community-based transplant and cell therapy network registry. A total of 357 intended recipients for approved anti-CD19+ CARTs were identified between 2018 to 2022. The median age at referral was 61 years; referral years were 2018 (4%), 2019 (14%), 2020 (18%), 2021 (26%), and 2022 (38%). Diagnoses included diffuse large B cell (69%), follicular (13%), follicular/large (7%), mantle cell (4%), or other (7%). Axicabtagene ciloleucel (62%), tisagenlecleucel (16%), brexucabtagene autoleucel (13%), and lisocabtagene maraleucel (9 %) were infused into 182 patients. The median durations between referral to consultation, consultation to apheresis, and collection to infusion were 11, 107, and 32 days, respectively. The median duration from consultation to CART infusion declined steadily from 207 days in 2019 to 108 days in 2022 (P &lt; .0001). A total of 124 patients (41%) did not receive CART, mostly for disease progression (34%) or poor health (15%). Multivariable logistic regression showed no significant differences in demographic, financial, or social determinants compared with those receiving CART. Notably, the proportion of ineligible patients declined from 53% in 2018-2020 to 34% by 2021-2022 (P = .001). In conclusion, 41% of community patients were unable to access timely CART therapy, mostly due to attrition from disease-related causes, and the overall time to infusion exceeded 4 months. Time to infusion and the proportion receiving CARTs improved over time. Reducing time to apheresis, early referral, and attention to salvage/bridging strategies are necessary.
Impact of thrombocytopenia on bleeding and thrombotic outcomes in adults with cancer-associated splanchnic vein thrombosis
Authors: Andersen Michael , Fernandez Turizo Maria J. , Dodge Laura E. , Hsu Charles , Barnum Kevin , Berry Jonathan , Zwicker Jeffrey I. , Patell Rushad 
Published: October 2024

Abstract
Malignancy is a risk factor for splanchnic vein thrombosis (SpVT). Data on the natural history of cancer-associated SpVT are limited. This was a single-center, retrospective cohort study of 581 adult patients with cancer and SpVT. We aimed to characterize the impact of thrombocytopenia on major bleeding and progression or recurrence of SpVT within 1 year of an initial cancer-associated SpVT diagnosis. Baseline thrombocytopenia (platelet &lt;100 × 103/μL within 15 days of SpVT diagnosis) was present in 39.5% of patients. A total of 39.2% of patients received therapeutic anticoagulation within 2 weeks of an SpVT diagnosis. The cumulative 1-year incidence of major bleeding was 10.7% (95% confidence interval [CI], 8.2-13.2) and 16.2% (95% CI, 13.2-19.2) for SpVT recurrence/progression. In the multivariable regression analysis, therapeutic anticoagulation was associated with increased major bleeding (adjusted risk ratio [aRR], 1.74; 95% CI, 1.08-2.81) and decreased progression/recurrence of SpVT (aRR, 0.55; 95% CI, 0.35-0.86). Baseline thrombocytopenia was not independently associated with either major bleeding (aRR, 0.76; 95% CI, 0.43-1.34) or progression/recurrence of SpVT (aRR, 1.14; 95% CI, 0.73-1.78). A secondary analysis using inverse probability of treatment weighting with propensity scores for baseline thrombocytopenia corroborated that patients with thrombocytopenia did not have an increased bleeding risk (adjusted hazard ratio [aHR], 0.81; 95% CI, 0.48-1.39). The multivariable analysis in which platelets were treated as a time varying covariate also did not reveal an association with major bleeding (aHR, 0.89; 95% CI, 0.55-1.45). Bleeding and thrombosis progression were frequent in patients with cancer-associated SpVT. Anticoagulation was associated with increased major bleeding and decreased thrombotic progression; thrombocytopenia did not impact the outcomes.
Role of fibroblasts in nonfibrotic autoimmune skin diseases
Authors: He Yuexi , Han Zhenxin , Zhang Qiuli , Liu Lin , Chang Jianmin 
Published: October 2024

AbstractAutoimmune diseases, a disease characterized by immune imbalance caused by the human immune system mistakenly attacking its own components, include vitiligo, psoriasis and atopic dermatitis (AD). Previous studies on autoimmune diseases have focused mainly on immune cells, keratinocytes and endothelial cells. Fibroblasts, the main cells that secrete the extracellular matrix (ECM) in the dermis, have been studied thoroughly in terms of fibrosis and wound healing. However, an increasing number of studies have shown that fibroblasts play an important role in nonfibrotic autoimmune skin diseases. In this article, the previously reported role of fibroblasts in nonfibrous autoimmune skin diseases such as psoriasis, vitiligo and AD is summarized to provide new ideas for the treatment of this disease.
Fungi as versatile biocatalytic tool for treatment of textile wastewater effluents
Authors: Pundir Ashok , Thakur Mohindra Singh , Prakash Suraj , Kumari Neeraj , Sharma Niharika , Parameswari Ettiyagounder , He Zhongqi , Nam Sunghyun , Thakur Mamta , Puri Sunil , Puranik Shriniketan , Kumar Sunil , Madhu  , Kumar Manoj 
Published: October 2024

AbstractTextile wastewater poses a significant environmental challenge, primarily due to the presence of diverse contaminants, especially textile dyes. Untreated release of these effluents directly into aquatic systems can lead to esthetic degradation, eutrophication, reduced photosynthetic activity, and accumulation of hazardous substances. Although conventional treatment methods are employed for reducing the contaminant load in effluents, they often are less efficient, thus prompting the exploration of innovative alternatives. Current review highlights myco-remediation as an inexpensive, promising and environmentally sustainable solution. Fungi, with their diverse decontamination mechanisms such as biosorption, biotransformation, and immobilization, prove effective in reducing heavy metals, persistent organic pollutants, and emerging contaminant levels present in these effluents, However, more research effort is needed to apply the biodegradation strategy to decompose completely the “forever chemicals” per‐ and polyfluorinated alkyl substances. Fungi play a key role in degrading and decolorizing textile dyes due to their biocatalytic activity mediated by the production of oxidative enzymes, such as laccases, lignin peroxidases, and manganese peroxidases, as well as their dye adsorption capabilities. This comprehensive review concentrates on fungi-based remediation of textile wastewater effluents, including the mechanisms they employ. While most studies concentrate on effluent treatment, this review also explores the concurrent utilization of biomass and growth kinetics for efficient reduction in pollutant concentrations. Further, the current work showed data on optimization of growth conditions such as pH, temperature and nutrient requirements that lead to efficient effluent decontamination.
Longitudinal investigation of a single variant SARS-CoV-2-outbreak in the immunologically naïve population of Ulvik, Norway
Authors: Mortensen Nicolay , Wensaas Knut-Arne , Solem Unni , Sivertsen Audun , Grewal Harleen M. S. , Rortveit Guri , Ulvestad Elling , Litleskare Sverre 
Published: October 2024

Abstract
Purpose
To perform an extensive investigation of the clinical features and long-term complications among the n = 134 adults and children with nucleic acid amplification test (NAAT) verified SARS-CoV-2-infection in the immunologically naïve population of Ulvik, Norway, during the single variant B.1.1.7 outbreak in late January through February 2021.

Methods
Every infected person regardless of whether symptoms of COVID-19 were present was invited to answer a web-based questionnaire at two- and seven months after testing positive. The period from initial infection to the first questionnaire was assessed retrospectively, and the time points at two- and seven months were assessed prospectively.

Results
A total of 87 of 134 (65%) NAAT-positive persons answered the first questionnaire, of which 35/87 (40%) were children, and 74 of 87 (85%) answered the second questionnaire. Children experienced symptoms less often than adults during the acute phase of infection (51% (18/35) versus 81% (42/52) (p = .004)). At two-months follow-up 88% (53/60) of participants with symptoms during the acute phase, including all children, reported no longer having symptoms. Among those with persisting symptoms at seven months, fatigue (18/25) and insomnia (16/24) were common.

Conclusion
In an immunologically naïve population infected with the SARS-CoV-2 B.1.1.7 variant, the clinical features of acute phase symptoms were similar to previous studies. Children underwent asymptomatic infection more often than adults, and adults more often experienced persisting symptoms. Insomnia and fatigue were common complaints among those with persisting symptoms seven months after infection.
Calculation of virtual 3D subtraction angiographies using conditional generative adversarial networks (cGANs)
Authors: Müller Sebastian Johannes , Einspänner Eric , Klebingat Stefan , Zubel Seraphine , Schwab Roland , Fuchs Erelle , Diamandis Elie , Khadhraoui Eya , Behme Daniel 
Published: October 2024

Abstract
Objective
Subtraction angiographies are calculated using a native and a contrast-enhanced 3D angiography images. This minimizes both bone and metal artifacts and results in a pure image of the vessels. However, carrying out the examination twice means double the radiation dose for the patient. With the help of generative AI, it could be possible to simulate subtraction angiographies from contrast-enhanced 3D angiographies and thus reduce the need for another dose of radiation without a cutback in quality. We implemented this concept by using conditional generative adversarial networks.

Methods
We selected all 3D subtraction angiographies from our PACS system, which had performed between 01/01/2018 and 12/31/2022 and randomly divided them into training, validation, and test sets (66%:17%:17%). We adapted the pix2pix framework to work on 3D data and trained a conditional generative adversarial network with 621 data sets. Additionally, we used 158 data sets for validation and 164 for testing. We evaluated two test sets with (n = 72) and without artifacts (n = 92). Five (blinded) neuroradiologists compared these datasets with the original subtraction dataset. They assessed similarity, subjective image quality, and severity of artifacts.

Results
Image quality and subjective diagnostic accuracy of the virtual subtraction angiographies revealed no significant differences compared to the original 3D angiographies. While bone and movement artifact level were reduced, artifact level caused by metal implants differed from case to case between both angiographies without one group being significant superior to the other.

Conclusion
Conditional generative adversarial networks can be used to simulate subtraction angiographies in clinical practice, however, new artifacts can also appear as a result of this technology.
Progress in physical activity research, policy, and surveillance in Canada: The global observatory for physical activity – GoPA!
Authors: Cathro Ashley , Spence John C , Cameron Christine , Varela Andrea Ramirez , Morales Diana , Kohn Eduardo Ribes , Pratt Michael , Hallal Pedro C 
Published: October 2024

Abstract
Background
The purpose of this paper is to examine the evolution of physical activity research and the comprehensiveness of national physical activity policies and surveillance systems in Canada.

Methods
A systematic review was conducted by the Global Observatory for Physical Activity (GoPA! ) on physical activity and health publications between 1950 and 2019. Findings from Canada were extracted and included in the present analysis. The number of articles published, female researcher involvement in authorship, author institution affiliations, and publication themes were examined. Policies were evaluated by determining if there was a standalone physical activity plan and if national guidelines existed. Surveillance systems were assessed for periodicity, instruments used, and age inclusivity.

Results
Out of 23,000 + publications analyzed worldwide; 1,962 included data collected in Canada. Physical activity research in Canada increased considerably from the 2000s to 2010s (543 articles vs. 1,288 articles), but an apparent stabilization has been observed more recently. Most physical activity publications in Canada focused on surveillance (37%), with fewer articles on policy (8%) and interventions (7%). The proportion of female first authors increased from 38% in the 1980s to 60% in the last decade. However, females remain the minority for senior authors. With respect to policy, “A Common Vision” is Canada’s national plan, which has a singular policy focus on physical activity. National surveillance data is collected regularly with both the Canadian Health Measures Survey (CHMS) and the Canadian Community Health Survey. In addition to self-report, the CHMS also collects accelerometer data from participants.

Conclusion
Through collaborative and coordinated action, Canada remains well equipped to tackle physical inactivity. Continued efforts are needed to enhance sustained awareness of existing physical activity promotion resources to increase physical activity.
Elemental analysis and micromorphological patterns of tooth/restoration interface of three ion-releasing class V restorations
Authors: Sarhan Hebatallah , Mehesen Rabab , Hamama Hamdi , Mahmoud Salah Hasab 
Published: October 2024

Abstract
Objectives
To evaluate and compare the ion-releasing capability of three different restorative systems at the restoration/tooth interface elemental analysis using energy-dispersive X-ray technique. Additionally, micromorphological patterns of the restoration/tooth interfaces was investigated.

Materials and methods
Eighteen freshly extracted sound human premolars were collected for the study. The premolars were randomly assigned into 3 groups (n = 6) based on the type of restorative materials used: Giomer (Beautifill II), ion-releasing composite (Activa Presto), and RMGI (Riva Light Cure). Half of the specimens in each group were tested after 24 h (the “immediate group”), while the remaining half were tested after 6 months of storage in deionized water (the “delayed group”). Standardized box-shaped cavities along the cervical area of teeth crowns and restored them with the assigned restorative material following manufacturers’ instructions. The specimens were sectioned buccolingually into 2 halves. One half of each specimen was subjected to elemental analysis using energy-dispersive X-ray technique (EDX), while the remaining half was sputter coated and underwent micromorphological analysis of the restoration/tooth interface using a scanning electron microscope (SEM). The collected data from elemental analysis test were tabulated and subjected to statistical analysis.

Results
The two-way ANOVA test showed significant differences in both phosphorus and calcium levels among the tested restorative systems (p < 0.05). In the immediate subgroup, RMGI recorded the highest phosphorus level (0.1527), followed by the ion-releasing composite (0.1172), while Giomer exhibited the least levels (0.0326) (p < 0.05). The ion-releasing composite group had the highest calcium level (0.2797), followed by RMGI (0.248), and Giomer (0.2385) respectively (p < 0.05). In the delayed subgroups, Giomer recorded the highest phosphorus level (0.1526), followed by the ion-releasing composite (0.1058), and RMGI group (0.0466) respectively (p < 0.05). RMGI had the highest calcium level (0.2801), followed by the ion-releasing composite (0.2659), and Giomer had the lowest level (0.1792) (p < 0.05). The micromorphological analysis of the restoration/tooth interfaces showed good adaptation between the composite and tooth substrate in different restorative groups.

Conclusions
The ion-releasing capability of the three restorative systems appears to be comparable. The rate of mineral release and diffusion is affected by time and composition.