bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gravity-Driven Film Flow of a Power-Law Fluid over a Wavy Substrate with Slip Condition
Authors: Selim R. S. , Zakaria Kadry 
Published: September 2024

Abstract
In the current manuscript, the flow of a thin film of a power-law fluid over a slippery topographical substrate is discussed.The von Karman–Pohlhausen method is used to develop the integral boundary layer (IBL)—model for the film thickness using an analytical approach.The findings are supported by earlier research on the resonance phenomena in gravity-driven Newtonian films with and without slippery properties. The novelty of this study lies in the influence of the slip condition at various power-law index n values.The study of the linear and non-linear resonance interactions between the free surface and the slippery undulating substrate yields expressions for the resonant Reynolds number for the largest free-surface amplitudes. The effects of shear-thinning and shear-thickening on the model system’s stability are taken into account when treating the slippery offer. The free surface amplitude is significantly affected by the slip length parameter’s rise, which has a major passive effect on the model system’s instability.
Correlation between glycated albumin (GA) and CHA2DS2-VASc score in comparison to GRACE score regarding outcomes in acute coronary syndrome patients undergoing percutaneous coronary intervention
Authors: Moustafa Ahmed , Gaber Sayed , Abdelfattah Ahmed , Ali Mohamed 
Published: September 2024

Abstract
Background
Acute coronary syndrome (ACS) is responsible for one-third of total deaths in people older than 35 years old. Number of prognostic models aims to estimate the future risk of mortality, or the combined risk of all-cause mortality or MI has been developed, such as GRACE score.

Objective
The aim of our study is to assess the utility of GA and CHA2DS2-VASc score in predicting outcomes in patients admitted with acute coronary syndromes.

Patients and methods
This study was conducted on 90 patients diagnosed with acute coronary syndrome who were admitted receiving PCI, CHA2DS2-VASc score was calculated on admission, and a serum sample for GA was withdrawn within 24 h from admission.

Results
Combined GA and CHA2DS2-VASc score could significantly predict MACCE with sensitivity 100%, specificity 79%, and diagnostic accuracy 80.9% and significantly predict hospital mortality with sensitivity 100%, specificity 75.3%, and diagnostic accuracy 76.7%; on the other hand, GRACE score can predict MACCE using cutoff point 112.5 with sensitivity 75% and specificity 66%.

Conclusion
It was concluded that GA and CHADSVASC score can significantly predict major adverse cardiovascular events, in-hospital mortality, and poor clinical outcomes.
What leader behaviors evoke employee innovative work behavior in Asia? Validation of a new survey scale
Authors: Tan Amy B. C. , van Dun Desirée H. , Wilderom Celeste P. M. 
Published: September 2024

Abstract
In Asian workplaces, effective innovative work behavior (IWB) presents challenges. Knowledge on how Asian leaders can promote employee IWB through their behavioral repertoire is needed. This assumption prompted us to develop and validate the so-called Innovative Leader Survey (ILS), covering a repertoire of leader behaviors by which employee IWB is stimulated in Asia. Study 1 interviewed 60 high-performing leaders and employees on such behaviors, bringing forth three leader-behavioral dimensions and survey items for fostering employee idea generation, promotion, and implementation, labeled Envisioning, Energizing, and Enabling. Study 2 involved 1,037 survey respondents through which we validated these three sets of specific leader behaviors. Study 3, with 287 respondents, established ILS’s discriminant validity while all of its 11 operationalized leader behaviors were found to predict their followers’ IWB after 4 months. Future research with the ILS is proposed to enrich theory and empirical research on the relationship between effective leadership and employees’ IWB in Asian organizations.
Deliberate synchronization of speech and gesture: effects of neurodiversity and development
Authors: Eigsti Inge-Marie , Pouw Wim 
Published: September 2024

AbstractThe production of speech and gesture is exquisitely temporally coordinated. In autistic individuals, speech-gesture synchrony during spontaneous discourse is disrupted. To evaluate whether this asynchrony reflects motor coordination versus language production processes, the current study examined deliberately performed hand movements during speech in youth with autism spectrum disorder (ASD) compared to neurotypical youth. Neurotypical adult performance provided a mature baseline. Participants read aloud rhythmic nursery rhymes, while producing a beat-like hand movement. An automated pixel-change video measure identified kinematic peaks; using smoothed acoustic envelope analyses, we identified peaks in speech. Results indicated few diagnostic group differences in explicit speech-movement coordination, although adolescent performance differed from adults. Adults demonstrated higher tempo and greater rhythmicity in their coordination; this group difference suggests that the method is sufficiently subtle to reveal individual differences and that this form of complex coordination undergoes ongoing maturation beyond adolescence. The sample is small, and thus results are necessarily preliminary. In the context of prior speech-gesture coordination studies, these findings of intact synchrony are consistent with the hypothesis that it is the demands of discourse planning, rather than motor coordination, that have led to prior findings of asynchrony during spontaneous speech; this possibility awaits future research.
Investigating social protection amongst platform workers in Germany: forced individualisation, hybrid income generation and undesired regulation
Authors: Beckmann Fabian , Glanz Sabrina , Hoose Fabian , Topal Serkan 
Published: September 2024

Abstract
The social protection of platform workers is considered one of the most precarious features and political challenges of this new form of employment. Still, there have only been a few empirical investigations on this issue to date. This article presents an explorative empirical analysis of the social protection of platform workers in Germany – a conservative welfare regime with a strong link between standard employment and institutionalised social protection. On the basis of an online survey amongst 719 self-employed platform workers, we examine how different employment patterns correspond to institutionalised protection against sickness and old age. We empirically explore different protection types and analyse how they differ regarding working conditions in platform work and individual social policy preferences. Findings reveal that conditions of platform work and social protection as well as demands and regulatory preferences vary notably across different clusters of platform workers. Still, the vast majority votes against obligatory social insurances for platform workers and favours self-employment over dependent employment. Against this background, we discuss challenges for future attempts aiming at improving social protection for platform workers. This study adds to the literature by empirically exploring platform workers’ social protection and social policy preferences, which have been overlooked to date.
Salt-responsive miRNA-SSR markers from Dongxiang wild rice: characterization and potential application in exploring salt-tolerant genetic resources
Authors: Gao Rifang , Chen Yong , Huang Jie , Mao Yingying , Zhou Yi , Xie Jiankun , Zhang Fantao 
Published: September 2024

AbstractMicroRNAs (miRNAs) play important roles in regulating salt tolerance in Dongxiang wild rice (DXWR, Oryza rufipogon Griff.). The development of salt-responsive miRNA-simple sequence repeat (SSR) markers will significantly bolster research on DXWR, providing novel tools for exploring salt-tolerant genetic resources and advancing the development of salt-tolerant rice varieties. In the present study, a total of 137 miRNA-SSR markers were successfully developed, specifically derived from miRNAs responsive to salt stress in DXWR. Subsequently, a subset of 20 markers was randomly selected for validation across three distinct DXWR populations, along with 35 modern rice varieties. Notably, 13 of these markers exhibited remarkable polymorphism. The polymorphic markers collectively amplified 52 SSR loci, averaging four alleles per locus. The polymorphism information content values associated with these loci spanned from 0.23 to 0.70, with a mean value of 0.49. Particularly noteworthy is the miR162a-SSR marker, which demonstrated distinct allelic patterns and holds potential as a diagnostic marker for discriminating the salt-tolerant rice varieties from the non-tolerant varieties. This study provides a valuable tool for genetic analysis and precision breeding, facilitating the identification and utilization of valuable salt-tolerant genetic resources.
On the Timescales of Border Fault Growth: Pleistocene Slip Acceleration and Lateral Border Fault Propagation in the Lower Shire Graben, East Africa
Authors: Dulanya Z. , Kolawole F. , Gallen S. F. , Williams J. N. 
Published: September 2024

AbstractNormal fault systems may grow by the lateral propagation of segments, yet little is known about the timescales over which this may occur and the implications for rift propagation. Footwall bedrock river networks provide a means to delineate the recent fault displacement patterns since erosional landscapes are sensitive recorders of rock uplift histories. Here, we analyze river profiles and map knickpoints in the Ruo River network and several adjacent rivers draining the footwalls of the en‐echelon Thyolo‐Muona‐Camacho border fault system of the Lower Shire Graben, southern East African Rift System. Using parameters calibrated in previous studies, we estimate the knickpoint initiation times and use linear river profile inversions to understand footwall uplift histories. Abrupt increases in bedrock river channel steepness indices approaching the faults suggest a recent acceleration in fault slip rates. Linear inversion of the bedrock river profiles reveals that footwall uplift rates accelerated from ∼0.1 to 0.3 mm/yr at ∼2–3 Ma in the Thyolo‐Muona footwalls. Later, at ∼0.75–1.0 Myr, farther southeast, the Camacho footwall river profiles show an increase in rock uplift rate from ∼0.05 to 0.2 mm/yr, but this signal decays moving southeast. Modern uplift rates along the Thyolo‐Muona section attain 0.33–0.56 mm/yr, and Camacho 0.19–0.29 mm/yr. We propose that within <2 Myr timescale, the border fault grew by an initial (Early Pleistocene) accelerated slip and hard linkage of the already‐nucleated segments, later followed by the southeastward lateral propagation of the system toward the adjacent rift, the Nsanje Graben.
Modeling Climate and Tectonic Controls on Bias in Measured River Incision Rates
Authors: DeLisle Clarke , Yanites Brian J. 
Published: September 2024

AbstractRates of land surface processes provide insights into climatic and tectonic influences on topography. Bedrock incision rates are estimated by dating perched landforms such as strath terraces, assuming a constant bedrock incision rate from terrace abandonment to the next terrace level or present river level. These estimates express biases from the stochastic nature of sediment and water discharge in controlling river incision as well as from using a mobile channel elevation as a reference frame, leading to different incision rates when calculated over different timeframes. We introduce a 1‐D model incorporating fluvial mechanics, tectonics, sediment, and climate variability to predict these biases and assess their sensitivity to climate and tectonics. Findings suggest biases intensify under highly variable climates and slow rock uplift, with climate periodicity being a primary control for our modeled scenarios. Our model provides a mechanism to improve river incision measurement uncertainty, impacting paleoclimate and tectonic geomorphology reconstructions.
The spinal cord injury (SCI) peer support evaluation tool: the development of a tool to assess outcomes of peer support programs within SCI community-based organizations
Authors: Sweet Shane N. , Shi Zhiyang , Pastore Olivia , Shaw Robert B. , Comeau Jacques , Gainforth Heather L. , McBride Christopher B. , Noonan Vanessa K. , Scott Launel , Flaro Haley , Casemore Sheila , Aslam Lubna , Clarke Teren , Martin Ginis Kathleen A. 
Published: September 2024

Abstract
Study design
Guided by the 4-step process outlined in the Consensus-based Standards for the selection of health Measurement INstruments (COSMIN) guideline, multiple methodologies were used: Delphi, literature reviews, ratings with consensus, think-aloud, and test-retest.

Objectives
The purpose of this study was to develop and test a spinal cord injury (SCI) peer support evaluation tool that meets the needs of community-based SCI organizations in Canada.

Setting
Peer support programs for people with SCI delivered by community-based SCI organizations.

Methods
This research was co-constructed with executives and staff from SCI community-based organizations, people with SCI, researchers, and students. Given the multiple steps of this study, sample size and characteristics varied based on each step. Participants included people with SCI who received peer support (mentees) or provided peer support (mentors/supporters) and staff of community-based organizations.

Results
In step 1, the 20 most important outcomes for SCI peer support were identified. In step 2 and 3, the 97 items were identified to assess the outcomes and by using rating and multiple consensus methodologies 20 items, one to assess each outcome, were selected. In step 4, content and face validity and test-retest reliability were achieved. The resulting SCI Peer Support Evaluation Tool consists of 20 single-item questions to assess 20 outcomes of SCI peer support.

Conclusion
Through a systematic process, the SCI Peer Support Evaluation Tool is now ready to be implemented to assess outcomes of SCI peer support programs delivered by community-based SCI organizations.
Abrupt increase in Arctic-Subarctic wildfires caused by future permafrost thaw
Authors: Kim In-Won , Timmermann Axel , Kim Ji-Eun , Rodgers Keith B. , Lee Sun-Seon , Lee Hanna , Wieder William R. 
Published: September 2024

AbstractUnabated 21st-century climate change will accelerate Arctic-Subarctic permafrost thaw which can intensify microbial degradation of carbon-rich soils, methane emissions, and global warming. The impact of permafrost thaw on future Arctic-Subarctic wildfires and the associated release of greenhouse gases and aerosols is less well understood. Here we present a comprehensive analysis of the effect of future permafrost thaw on land surface processes in the Arctic-Subarctic region using the CESM2 large ensemble forced by the SSP3-7.0 greenhouse gas emission scenario. Analyzing 50 greenhouse warming simulations, which capture the coupling between permafrost, hydrology, and atmosphere, we find that projected rapid permafrost thaw leads to massive soil drying, surface warming, and reduction of relative humidity over the Arctic-Subarctic region. These combined processes lead to nonlinear late-21st-century regime shifts in the coupled soil-hydrology system and rapid intensification of wildfires in western Siberia and Canada.
Cryo-EM structures of the Spo11 core complex bound to DNA
Authors: Yu You , Wang Juncheng , Liu Kaixian , Zheng Zhi , Arter Meret , Claeys Bouuaert Corentin , Pu Stephen , Patel Dinshaw J. , Keeney Scott 
Published: September 2024

Abstract
DNA double-strand breaks that initiate meiotic recombination are formed by the topoisomerase-relative enzyme Spo11, supported by conserved auxiliary factors. Because high-resolution structural data have not been available, many questions remain about the architecture of Spo11 and its partners and how they engage with DNA. We report cryo-electron microscopy structures at up to 3.3-Å resolution of DNA-bound core complexes of Saccharomyces cerevisiae Spo11 with Rec102, Rec104 and Ski8. In these structures, monomeric core complexes make extensive contacts with the DNA backbone and with the recessed 3′-OH and first 5′ overhanging nucleotide, establishing the molecular determinants of DNA end-binding specificity and providing insight into DNA cleavage preferences in vivo. The structures of individual subunits and their interfaces, supported by functional data in yeast, provide insight into the role of metal ions in DNA binding and uncover unexpected structural variation in homologs of the Top6BL component of the core complex.
Chromosome-level genome assembly of Tritrichomonas foetus, the causative agent of Bovine Trichomonosis
Authors: Abdel-Glil Mostafa Y. , Solle Johannes , Wibberg Daniel , Neubauer Heinrich , Sprague Lisa D. 
Published: September 2024

AbstractTritrichomonas foetus is a parasitic protist responsible for bovine trichomonosis, a reproductive disease associated with significant economic burden to the livestock industry throughout the world. Here, we present a chromosome-level reference genome of T. foetus -KV-1 (ATCC 30924) using short-read (Illumina Miseq), long-read (Oxford Nanopore) and chromatin-linked (Hi-C) sequencing. This is the first chromosome-level genome of a parasitic protist of the order Tritrichomonadida and the second within the Parabasalia lineage, after Trichomonas vaginalis, the human-associated causative agent of the sexually transmitted infection in humans. Our constructed genome is 148 Mb in size, with a N50 length of the scaffolds of 22.9 Mb. The contigs are anchored in five super-scaffolds, corresponding to the expected five chromosomes of the species and covering 78% of the genome assembly. We predict 41,341 protein-coding genes, of which 95.10% have been functionally annotated. This high-quality genome assembly serves as a valuable reference genome for T. foetus to support future studies in functional genomics, genetic conservation and taxonomy.
Local and non-local effects (on the posterior chain) of four weeks of foot exercises: a randomized controlled trial
Authors: Gabriel Anna , Ridge Sarah T. , Birth Michael , Horstmann Thomas , Pohl Torsten , Konrad Andreas 
Published: September 2024

AbstractThis study investigated the local, remote, and contralateral effects of a four-week intrinsic foot muscle exercise intervention in recreationally active participants on foot parameters, flexibility, and performance of the posterior chain (PC). Twenty-eight healthy participants (12f, 16m) were randomly assigned to a control group or performed 2 × 6 min of foot exercises twice daily unilaterally at least five days/week for four weeks. At baseline (M1), after the intervention (M2), and after a four-week wash-out period (M3), we assessed bilateral Foot Posture Index-6, medial longitudinal arch mobility, single-leg stance balance, range of motion (ROM) (first metatarsophalangeal joint and ankle), and flexibility and performance of the PC. The FPI-6 score changes over time differed significantly between groups for both legs, improving by 26% in the trained- (p < .001) and 11% in the untrained leg (p = .02) in the intervention group from M1 to M2. Improvements were maintained at M3 for the trained leg (p = .02). Ankle range of motion and balance of the trained leg improved from M1 to M2, yet only became significant at M3 (ROM: p = .02; balance: p = .007). The other parameters did not change significantly. A four-week foot exercise intervention might have local but no remote effects in healthy young adults.German Clinical Trial Register (DRKS00027923) (24/08/2022).
Applications of blockchain technology in peer-to-peer energy markets and green hydrogen supply chains: a topical review
Authors: Bhavana G. B. , Anand R. , Ramprabhakar J. , Meena V. P. , Jadoun Vinay Kumar , Benedetto Francesco 
Published: September 2024

AbstractCountries all over the world are shifting from conventional and fossil fuel-based energy systems to more sustainable energy systems (renewable energy-based systems). To effectively integrate renewable sources of energy, multi-directional power flow and control are required, and to facilitate this multi-directional power flow, peer-to-peer (P2P) trading is employed. For a safe, secure, and reliable P2P trading system, a secure communication gateway and a cryptographically secure data storage mechanism are required. This paper explores the uses of blockchain (BC) in renewable energy (RE) integration into the grid. We shed light on four primary areas: P2P energy trading, the green hydrogen supply chain, demand response (DR) programmes, and the tracking of RE certificates (RECs). In addition, we investigate how BC can address the existing challenges in these domains and overcome these hurdles to realise a decentralised energy ecosystem. The main purpose of this paper is to provide an understanding of how BC technology can act as a catalyst for a multi-directional energy flow, ultimately revolutionising the way energy is generated, managed, and consumed.
Positron emission tomography combined with serum biomarkers detects fibrotic MASH
Authors: Romeo Sean , Chan Connie , Matsukuma Karen , Corwin Michael T. , Lyo Victoria , Chen Shuai , Wang Guobao , Sarkar Souvik 
Published: September 2024

AbstractMetabolic dysfunction-associated steatohepatitis (MASH) is a rising global disease signaling the urgent need for non-invasive tests (NITs). Recent work demonstrated that dynamic 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging can identify MASH by measuring liver glucose transport rate, K1, and liver CT attenuation. By combining dynamic PET/CT with the serum-based fibrosis-4 (FIB-4) test, we were able to better distinguish clinical MASH from fibrotic subtypes, enabling determination of the core tenets of MASH: steatosis, inflammation, and fibrosis. Future studies using FDG-PET technology can further enable concomitant prediction of MASH severity and extrahepatic comorbidities such as cardiovascular disease.
Cancer associated variant enrichment CAVE, a gene agnostic approach to identify low burden variants in chronic lymphocytic leukemia
Authors: Yaacov Adar , Lazarian Gregory , Pandzic Tatjana , Weström Simone , Baliakas Panagiotis , Imache Samia , Lefebvre Valérie , Cymbalista Florence , Baran-Marszak Fanny , Rosenberg Shai , Soussi Thierry 
Published: September 2024

AbstractIntratumoral heterogeneity is an important clinical challenge because low burden clones expressing specific genetic alterations drive therapeutic resistance mechanisms. We have developed CAVE (cancer-associated variant enrichment), a gene-agnostic computational tool to identify specific enrichment of low-burden cancer driver variants in next-generation sequencing (NGS) data. For this study, CAVE was applied to TP53 in chronic lymphocytic leukemia (CLL) as a cancer model. Indeed, as TP53 mutations are part of treatment decision-making algorithms and low-burden variants are frequent, there is a need to distinguish true variants from background noise. Recommendations have been published for reliable calling of low-VAF variants of TP53 in CLL and the assessment of the background noise for each platform is essential for the quality of the testing. CAVE is able to detect specific enrichment of low-burden variants starting at variant allele frequencies (VAFs) as low as 0.3%. In silico TP53 dependent and independent analyses confirmed the true driver nature of all these variants. Orthogonal validation using either ddPCR or NGS analyses of follow-up samples confirmed variant identification. CAVE can be easily deployed in any cancer-related NGS workflow to detect the enrichment of low-burden variants of clinical interest.