bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening for Psychiatric Disorders in Chronic Rhinosinusitis Patients Waiting for Surgery: A Prospective Cross‐Sectional Study
Authors: Peng Liang , Wang Hui‐Fang , Wang Dong‐Fang , Wen Yi‐Hui , Zhong Hua , Wen Wei‐Ping , Li Jian 
Published: October 2024

ABSTRACTObjectiveTo assess the prevalence of depression, anxiety, insomnia and somatic symptom disorder (SSD) in chronic rhinosinusitis (CRS) patients who were waiting for surgery and to predict these psychiatric disorders using the 22‐item Sinonasal Outcome Test (SNOT‐22).DesignA prospective cross‐sectional study.SettingThe rhinology ward at our institution, a tertiary hospital.ParticipantsAdult patients (> 18 years) diagnosed with CRS who were admitted to the rhinology ward for endoscopic sinus surgery and were able to understand and complete the study questionnaires.Main Outcome MeasuresPatient Health Questionnaire‐9 (PHQ‐9), Generalised Anxiety Disorder‐7 (GAD‐7), Insomnia Severity Index (ISI), Patient Health Questionnaire‐15 (PHQ‐15) and SNOT‐22.ResultsOf the 159 participants recruited, 58 were at risk of depression (defined by PHQ‐9 > 4, while 25 with PHQ‐9 > 9), 49 were at risk of anxiety (defined by GAD‐7 > 4, while 25 with GAD‐7 > 9), 81 were at risk of insomnia (defined by ISI > 7, while 51 with ISI > 14) and 69 were at risk of SSD (defined by PHQ‐15 > 4, while 24 with PHQ‐15 > 9). The SNOT‐22 score was closely correlated with the scores of psychometric tests and was an independent predictor of these psychiatric disorders. Patients with a high SNOT‐22 score (> 30) are likely to be affected by comorbid psychiatric disorders and should be further evaluated by otolaryngologists.ConclusionDepression, anxiety, insomnia and SSD are prevalent in CRS patients. Otolaryngologists should have a low threshold to ask the patient about psychiatric symptoms, especially for patients with an SNOT‐22 score > 30.
Insights into hair dye use and self‐reported adverse skin reactions in the Dutch general population: A cross‐sectional questionnaire‐based study
Authors: Rosenberg Fieke M. , Ofenloch Robert F. , van der Most Peter J. , Snieder Harold , Schuttelaar Marie L. A. 
Published: October 2024

AbstractBackgroundHair dyes are widely used in daily life. However, data on self‐reported adverse skin reactions are scarce.ObjectivesTo estimate the proportion of lifetime hair dye use and self‐reported adverse skin reactions in the Dutch general population, and to investigate the association between (adverse skin reactions to) hair dye use and contact allergy‐related factors.MethodsThis cross‐sectional study collected questionnaire‐derived data from the Lifelines cohort. Logistic regression analyses were conducted between (adverse skin reactions to) hair dye use and black henna tattoo use, reactions to henna tattoos, patch testing, hand eczema and an occupation as hairdresser or beautician.ResultsThe proportion of hair dye use was 63.1% of 70 987 participants, of which 6.8% experienced adverse skin reactions, mostly mild (77.7%). Hair dye users and those with skin reactions were both positively associated (p < 0.05) with female sex, middle‐age, (positive) patch test results and hairdresser or beautician occupations. Hair dye users were more likely to have had henna tattoos, and those with reactions to hair dye were more likely to have had reactions to henna tattoos.ConclusionsHair dye use is prevalent among the Dutch general population and frequently causes adverse skin reactions, especially in females who had black henna tattoos.
The prognostic value of [18F]FDG PET/CT texture analysis prior to transplantation for unresectable colorectal liver metastases
Authors: Stern Nadide Mutlukoca , Mikalsen Lars Tore Gyland , Dueland Svein , Schulz Anselm , Line Pål‐Dag , Stokke Caroline , Grut Harald 
Published: October 2024

AbstractIntroductionTo determine whether heterogeneity in colorectal liver metastases (CRLM) 18F fluorodeoxyglucose [18F]FDG distribution is predictive of disease‐free survival (DFS) and overall survival (OS) following liver transplantation (LT) for unresectable CRLM.MethodsThe preoperative [18F]FDG positron emission tomography/computed tomography examinations of all patients in the secondary cancer 1 and 2 studies were retrospectively assessed. Maximum standardized uptake value (SUVmax), metabolic tumour volume (MTV), and six texture heterogeneity parameters (joint entropyGLCM, dissimilarityGLCM, grey level varianceSZM, size zone varianceSZM, and zone percentageSZM, and morphological feature convex deficiency) were obtained. DFS and OS for patients over and under the median value for each of these parameters were compared by using the Kaplan Meier method and log rank test.ResultsTwenty‐eight out of 40 patients who underwent LT for unresectable CRLM had liver metastases with uptake above liver background and were eligible for inclusion. Low MTV (p < 0.001) and dissimilarityGLCM (p = 0.016) were correlated to longer DFS. Low MTV (p < 0.001) and low values of the texture parameters dissimilarityGLCM (p = 0.038), joint entropyGLCM (p = 0.015) and zone percentageSZM (p = 0.037) were significantly correlated to longer OS. SUVmax was not correlated to DFS and OS.ConclusionAlthough some texture parameters were able to significantly predict DFS and OS, MTV seems to be superior to predict both DFS and OS following LT for unresectable CRLM.
Practical Approach to Reporting Based on the International System for Serous Fluid Cytopathology
Authors: Viljanen Eliisa , Kholová Ivana , Chandra Ashish 
Published: October 2024

ABSTRACTThe International System for Serous Fluid Cytopathology (TIS) is intended for reporting cytological specimens from serous cavities: pleural, abdominal and pericardial cavities. TIS is being adopted into practice in cytology laboratories worldwide. In this system, there are six diagnostic categories: non‐diagnostic, negative for malignancy, atypia of undetermined significance, suspicious for malignancy, malignant‐primary and malignant‐secondary. Malignant‐primary category almost always implies malignant mesothelioma and malignant‐secondary usually refers to metastasis from carcinoma but also to involvement of serous cavity by haematolymphoid and other malignancies. When evaluating effusion cytological specimen adequacy, the factors that must be considered are sample volume, cellular content and cellular preservation. In the diagnostic analysis and interpretation, it is helpful to consider systematically all basic cytomorphological components in a sample. The basic components are architecture, cell populations, cell size, cytoplasm, nuclei and background elements. One important requirement for a successful evaluation of an effusion cytological specimen is sufficient clinical and radiological information in a referral. Clinical information may guide ancillary testing. In the present review, we provide a practical and educational approach to reporting serous effusion cytology based on the TIS.
Pegylated interferon‐α2a in cutaneous T‐cell lymphoma – a multicenter retrospective data analysis with 70 patients
Authors: Hansen‐Abeck Inga , Geidel Glenn , Abeck Finn , Kött Julian , Cankaya Rohat , Dobos Gabor , Mitteldorf Christina , Nicolay Jan P. , Albrecht Jana D. , Menzer Christian , Livingstone Elisabeth , Mengoni Miriam , Braun Andreas D. , Wobser Marion , Klemke Claus‐Detlev , Tratzmiller Sabine , Assaf Chalid , Terheyden Patrick , Klespe Kai‐Christian , Schneider Stefan W. , Booken Nina 
Published: October 2024

SummaryBackgroundInterferon‐alpha is an important therapeutic option for the treatment of the cutaneous T‐cell lymphomas (CTCL). Since the approved recombinant interferon‐α‐2a (IFN‐α2a) has no longer been produced since January 2020, pegylated interferon‐α2a (pegIFN‐α2a) can be used as an alternative treatment, even though it is not approved for the treatment of CTCL. The aim of this multicentre study was to generate comprehensive data on the efficacy and tolerability of pegIFN‐α2a in the treatment of CTCL.Patients and MethodsA multicenter retrospective study was conducted with 70 patients with CTCL from twelve German skin centers.ResultsIn total, 70 patients were included in the study, with 57.2% male and a mean age of 58.8 ± 14.9 years. Mycosis fungoides was present in 71.4% of cases and Sézary Syndrome in 28.6%. An overall response rate of 55.2% was observed with pegIFNα‐2a therapy. In 50% of cases, therapy was discontinued after 63.6 ± 33.5 weeks. The most common reason for discontinuation was adverse events, which occurred in 68.6% of cases and which were classified as severe in 29.2%. Blood count changes, fatigue and liver toxicity occurred most frequently.ConclusionsOur analysis provides comprehensive data on the efficacy and tolerability of pegIFNα‐2a therapy in patients with CTCL. In terms of response rates and side effect profile, pegIFNα‐2a appears to be comparable to IFN‐α2a therapy.
Reinforced pain catastrophizing during menstrual phase among women with primary dysmenorrhea is mediated by cerebral blood flow in the medial prefrontal cortex
Authors: Shang Meiling , Liu Huiping , Ma Ling , Fan Tongtong , Bai Weixian , Yang Jing , Quan Lu , Zhang Yuchen , Dun Wanghuan 
Published: October 2024

AbstractPain catastrophizing is a prominent psychological factor that is strongly correlated with pain. Although the complex properties of pain catastrophizing vary across different pain phases, the contribution of chronic pain to its progression from a general trait to a higher state remains unclear. This study aimed to examine the neural mechanisms and degree to which pain catastrophizing is reinforced in the context of primary dysmenorrhea (PDM), one of the most prevalent gynaecological complaints experienced by women of reproductive age. Altogether, 29 women with moderate‐to‐severe PDM were included in this study. Arterial spin labelling was used to quantify the cerebral blood flow (CBF) in each participant in both the pain‐free and painful phases. The pain catastrophizing scale (PCS) was completed in two phases, and the Short‐Form McGill Pain Questionnaire was completed in the painful phase. Compared with pain catastrophizing in the pain‐free phase (PCSpf), pain catastrophizing in the painful phase (PCSp) is higher and positively correlated with the composite factor of menstrual pain. CBF analysis indicated that the PCSp is positively associated with CBF in the frontal cortex, hippocampus and amygdala. The reinforcement of pain catastrophizing correlates with CBF in the prefrontal cortex. Specifically, the medial prefrontal cortex, which correlates with pain state, plays a crucial role in mediating the reinforcing effect of pain in the PCSp. These results promote the mechanical comprehension of pain catastrophizing management in individuals with chronic pain.
Advancing healthcare systems: A tri‐tier architecture by using data communication, AI data generative and regulation and compliance standards
Authors: Qureshi Kashif Naseer , Nafea Hanaa , Kim Pyoungwon 
Published: October 2024

AbstractTraditional healthcare systems have suffered from different data communication, security, data processing, and compliance issues. The traditional systems are also not well equipped to handle the new technologies like Artificial Intelligence (AI) by enabling more accurate diagnostics, personalized treatment plans, and improved patient outcomes. The existing data communication and security protocols and compliance are also not fully implemented to tackle the system's challenges. This article proposes a Tri‐Tier architecture by using data communication, AI data generative, and regulation and compliance tiers. The data communication tier is based on advanced sensing and monitoring technologies like cloud and edge‐based systems integrated with security detection mechanisms. The edge and cloud layer provides the all functions of the perception layer like smart sensing, visual sensing, and monitoring services, and can control the device's perception and behaviour. The second tier provides the AI data generative functionalities to handle real‐time synthetic medical images for predictive analytics to enhance patient care. This tier also automates routine tasks, such as administrative work and data analysis, which can free up healthcare professionals to focus on more complex tasks. The last regulation and compliance tier is responsible for handling the standards and compliance for healthcare systems. Experiments are conducted to test the data communication and security level of the proposed architecture. The results showed the suitability of existing solutions and synchronization with the proposed architecture.
High levels of seed dispersal by a declining wintering population of migratory geese
Authors: Jiménez‐Martín Iciar , Monreal Adrián , Martín‐Vélez Víctor , Navarro‐Ramos María J. , Fox Anthony D. , Lovas‐Kiss Ádám , Green Andy J. 
Published: October 2024

Abstract

Ducks are known to be important seed dispersers, but the role of geese in plant dispersal is less clear. Wintering populations of migratory geese are undergoing rapid changes in distribution and habitat use in response to climate change and changes in land use, and the implications for seed dispersal have not previously been studied. At the southern end of Eurasian goose flyways, numbers are declining through short‐stopping.

The Doñana wetlands, or ‘marismas del Guadalquivir’, in south‐west Spain were formerly Europe's most important wintering grounds for the greylag goose Anser anser. There, we collected 151 faecal samples to compare seed dispersal by endozoochory in early and late winter in natural marshes and ricefields. We also tested seed germinability and simulated potential seed dispersal distances to assess the importance of this decreasing wintering population for dispersal of dry‐fruited plants previously assumed to rely on abiotic seed dispersal over short distances.

We retrieved 1196 intact seeds belonging to 24 different taxa, including eight species not previously reported from waterfowl (Anatidae) vectors. Seeds were present in 47% of samples, with a peak of 90% in natural marshes in November, compared to only 27% in ricefields at the same time, or in the same marsh site in February. Seed abundance and richness per sample were significantly higher in early than late winter, and in natural compared to in artificial wetlands. Major differences in plant species composition between sampling sites were partly related to habitat differences and moisture requirements of individual species. Germinability in aquatic plants was higher when gut passage was followed by cold storage for 2 months prior to germination tests.

We simulated seed dispersal events to and from our sampling sites using GPS tracking of three geese. This suggested that seeds can be dispersed up to 25 km during daily movements, with a median of 0.2–5 km, depending on the sampling site. The most frequent dispersal syndrome assigned to the plant species dispersed by geese was barochory (gravity), and geese disperse plants much farther than the mechanisms predicted by their syndromes.

Geese likely have an important role in the dispersal and connectivity of plant populations within and beyond Mediterranean wetlands, providing an ecosystem service which is threatened by changes in migratory behaviour. Our results highlight the importance of studying seed dispersal interactions involving migratory waterbirds in the current context of species loss and distribution shifts, as many crucial interactions may be disappearing even before they are discovered.
Recovery of Soil Microbial Metabolism After Rewetting Depends on Interacting Environmental Conditions and Changes in Functional Groups and Life History Strategies
Authors: Li Xiankun , Leizeaga Ainara , Rousk Johannes , Zhou Siyuan , Hugelius Gustaf , Manzoni Stefano 
Published: October 2024

ABSTRACTClimate change is causing an intensification of soil drying and rewetting events, altering microbial functioning and potentially destabilizing soil organic carbon. After rewetting, changes in microbial community carbon use efficiency (CUE), investment in life history strategies, and fungal to bacterial dominance co‐occur. Still, we have yet to generalize what drives these dynamic responses. Here, we collated 123 time series of microbial community growth (G, sum of fungal and bacterial growth, evaluated by leucine and acetate incorporation, respectively) and respiration (R) after rewetting and calculated CUE = G/(G + R). First, we characterized CUE recovery by two metrics: maximum CUE and time to maximum CUE. Second, we translated microbial growth and respiration data into microbial investments in life history strategies (high yield (Y), resource acquisition (A), and stress tolerance (S)). Third, we characterized the temporal change in fungal to bacterial dominance. Finally, the metrics describing the CUE recovery, investment in life history strategies, and fungal to bacterial dominance after rewetting were explained by environmental factors and microbial properties. CUE increased after rewetting as fungal dominance declined, but the maximum CUE was explained by the CUE under moist conditions, rather than specific environmental factors. In contrast, higher soil pH and carbon availability accelerated the decline of microbial investment in stress tolerance and fungal dominance. We conclude that microbial CUE recovery is mostly driven by the shifting microbial community composition and the metabolic capacity of the community, whereas changes in microbial investment in life history strategies and fungal versus bacterial dominance depend on soil pH and carbon availability.
Pathways for Strengthening Lived Experience Leadership for Transformative Systems Change: Reflections on Research and Collective Change Strategies
Authors: Loughhead Mark , Hodges Ellie , McIntyre Heather , Procter Nicholas , Barbara Anne , Bickley Brooke , Martinez Lee , Albrecht Leticia , Huber Lisa 
Published: October 2024

ABSTRACTIntroductionThe Activating Lived Experience Leadership (ALEL) project was a South Australian participatory action research project that aimed to improve the ways lived experience is recognised, valued and integrated across mental health and social sector systems. ALEL was completed during 2019–2021, where it engaged 182 participants in generating community action and research knowledge.ObjectiveOur paper discusses the project's processes of building a collective partnership among lived experience leaders and other leaders from within the sector, so that the actions and strategies identified through research could be implemented by systems‐level impact. We describe the collaborative process and key learnings that resulted in eight key action areas for transformative systems change in South Australia.MethodsThe project invited a diverse range of self‐identified lived experience and other leaders to be involved in a PAR process featuring formal qualitative research (focus groups, surveys and interviews) as well as community development activities (leaders' summit meetings, consultations, training and community of practice meetings). These processes were used to help us describe the purpose, achievements and potential of lived experience leadership. Project priorities and systems‐level analysis was also undertaken with lived experience sector leaders and project advisors across two leaders' summit meetings, integrating research outcomes with sector planning to define high‐level actions and a vision for transformational change.ResultsParticipatory action research as informed by systems change and collective impact strategies assisted the project to generate detailed findings about the experiences and complexities of lived experience leadership, and collective responses of how systems could better support, be accountable to and leverage lived experience perspectives, experience and peer‐work approaches.ConclusionSystems change to define, value and embed lived experience leadership benefits from collective efforts in both formal research and sector development activities. These can be used to generate foundational understandings and guidance for working together in genuine ways for transforming mental health and social sector systems, experience and outcomes.Public ContributionMembers of lived experience communities codesigned the project, and contributed to project governance and the development of all findings and project reports.
HMGA2‐positive salivary gland neoplasms with prominent trabecular/canalicular morphology: a focus on carcinomas arising within this phenotype
Authors: Dababneh Melad N , Azzato Elizabeth M , Nakitandwe Joy , Cracolici Vincent , Shah Akeesha A 
Published: October 2024

AimsPleomorphic adenoma (PA) with a prominent trabecular/canalicular morphology has consistent HMGA2 protein expression, and association with HMGA2 fusions. We report our experience with this subtype, with emphasis on the carcinomas that can arise in this context.Methods and ResultsA retro‐ and prospective review (2013–2024) of major salivary gland tumours with prominent trabecular/canalicular morphology was performed. Twenty‐one parotid tumours met the criteria: 14 benign (66.7%), six carcinomas (28.6%), and one of uncertain behaviour (4.7%). HMGA2 immunohistochemistry (IHC) was performed on all cases. Next‐generation sequencing was successfully performed on 18. Seven benign cases had a conventional PA component. In all cases, the tumour cells in these trabecular/canalicular areas demonstrated variable papillary thyroid carcinoma‐like nuclear changes, including chromatin clearing, overcrowding, membrane irregularities, and intranuclear pseudoinclusions. Benign tumours were well‐demarcated, whereas carcinomas demonstrated either a multinodular pattern of invasion or subtle infiltration. Two carcinomas showed increased cytologic atypia and architectural complexity and one had perineural invasion. By IHC, all were positive for HMGA2. In the trabecular/canalicular areas, there was consistent strong expression of CAM5.2, S‐100, and SOX‐10 and variable expression of p63 but negative p40. HMGA2 alterations were detected in 16 of 18 cases (89%). Follow‐up was available on two carcinomas, with one being locally recurrent.ConclusionWhile most HMGA2‐positive salivary gland neoplasms with a prominent trabecular/canalicular growth pattern are benign, they, like traditional PAs, may give rise to carcinomas that can locally recur. These carcinomas can be deceptively bland, subtly infiltrative, or have a multinodular pattern of invasion.
Synthesis of mullite ceramics from powdered mine tailings reinforced with Al2O3
Authors: Kamara Saidu , Ma Yukun , Foday Edward Hingha , Kallon Hadji Dauda Smaila 
Published: October 2024

AbstractMullite is an aluminosilicate compound that can be fabricated from various sources of raw materials. Mullite (α) was synthesized from six different mine tailings reinforced with alumina. The tailings were finely ground into powder to determine their chemical components using X‐ray fluorescence (XRF) and X‐ray diffraction (XRD) spectroscopic technologies. Silica was discovered in all the tailings in significant quantities followed by alumina (high purity α‐alumina). 50 g of the first sample which composed 68.8 w(M)/10−2 of SiO2 and 13.2 w(M)/10−2 of Al2O3 was measured, reinforced with 81.1 g of Al2O3 and subjected to a high‐energy ball mill for 30 min to enhance the reaction between SiO2 and Al2O3. The process was repeated for all six powdered tailings. Each mixture was sintered at 1100°C and 1200°C in a muffle furnace for 4 hours at a heating rate of 10°C/min. The sintered materials were characterized using SEM, EDS, XRD, and FTIR techniques. Results and analysis show a significant amount of prismatic α‐mullite formed in all six sintered samples. The formation of mullite crystals was observed to increase with an increase in temperature from 1100°C to 1200°C. The phenomenal fabrication of mullite from mine tailings is significant in ceramic technology.