bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trust Building Recruitment Strategies for Researchers Conducting Studies in African American (AA) Churches
Authors: Bonner Gloria , Williams Sharon , Wilkie Diana , Hart Alysha , Burnett Glenda , Peacock Geraldine 
Published: August 2016

Background: An initial and vital important step in recruiting participants for church-based hospice and palliative care research is the establishment of trust and credibility within the church community. Mistrust of medical research is an extremely important barrier hindering recruitment in African American (AA) communities. A church-based EOL dementia education project is currently being conducted at four large urban AA churches. Church leaders voiced mistrust concerns of previous researchers who conducted investigations in their faith-based institutions. We explored strategies to ameliorate the mistrust concerns. Specific aim: To identify trust-rebuilding elements for researchers following others who violated trust of AA church leaders. Methods: Face-to-face, in-depth interviews were conducted from a convenient sample of four established AA church leaders. Interviews were held in the informants’ churches to promote candor and comfort in revealing sensitive information about trust /mistrust. Content analysis framework was used to analyze the data. Elements identified from the analysis were then used to create themes. Results: Multidimensional overarching themes emerged from the analysis included: Experience with researchers (positive and extremely negative), violation of trust and trust building strategies. Conclusions: Findings suggest that researchers who wish to conduct successful studies in the AA religious institutions must implement trust rebuilding strategies that include mutual respect, collaboration and partnership building. If general moral practices continue to be violated, threat to future hospice and palliative care research within the institutions may prevail. Thus, potential benefits are thwarted for the church members, AA community, and advancement of EOL care scholarship.
An equal marriage retrospective in two voices: Where have ten years taken us?
Authors: Onishenko Dawn M , Erbland Julie A 
Published: August 2016

This article represents the reflexive journey of one of six couples that launched a Constitutional Challenge to the definition of marriage. An account of our motivation for marriage deconstructs the experience from two disparate, yet shared, spaces. Using reflection and documentation, we explore multiple truths and realities of what the case, and the ‘right to marry’, meant to us: then, and now – 10 years later. In recounting our story, we expose the embodiment of risk taken by sexual minorities when engaging in activism and claiming heteronormative public spaces. Each with our own epistemological foundation, we explore the pitfalls and possibilities of marriage activism and consider its role as a space of queer liberation. Illustrating how the struggle for equal marriage is situated in the messy notion of what it means to be queer, we posit two narratives as a means of challenging dominant discourse. To research marriage as an objective ‘reality’ is to desexualize and depersonalize queer identity; an autoethnographic account claims the subjective sexual identity and facilitates a discussion of the nuances and complexities of queer lives and choices. Given the vitriolic marriage debate, documenting and deconstructing our experience is an important element of queer history and praxis. Using reflexivity to explore our individual and collective perspectives and reflect upon how those experiences were shaped through intersection with family, friends, each other, community and society allows us to claim our insider positionality and challenge queer/straight binaries, force conversations about these binaries, and demonstrate how the personal is political.
Shoulder Injuries in Individuals Who Participate in CrossFit Training
Authors: Summitt Ryan J. , Cotton Ryan A. , Kays Adam C. , Slaven Emily J. 
Published: August 2016

Background: CrossFit, a sport and fitness program, has become increasingly popular both nationally and internationally. Researchers have recently identified significant improvements in health and wellness due to CrossFit. However, some individuals assert that CrossFit poses an inherent risk of injury, specifically to the shoulder, due to the intensity of training. Currently, there is limited evidence to support this assertion. Hypothesis: Exercises performed during CrossFit do not place the shoulder at greater risk for injury. Injury rates are comparable to other sports of similar intensity. Study Design: Descriptive survey study. Level of Evidence: Level 5. Methods: An electronic survey was developed and dispersed to approximately 980 individuals who trained in CrossFit gyms. The survey identified demographic data, training characteristics, and the prevalence of injury over a 6-month period in individuals who participated in CrossFit training. Results: A total of 187 (19.1%) individuals completed the survey. Forty-four (23.5%) indicated that they had experienced a shoulder injury during CrossFit training over the previous 6 months. Of those who reported injury, 17 (38.6%) stated that this injury was an exacerbation of a previous injury sustained prior to starting CrossFit. There was no significant relationship between several demographic and training variables and shoulder injury. All shoulder injuries occurred at a rate of 1.94 per 1000 hours training, while “new” shoulder injuries occurred at a rate of 1.18 per 1000 hours training. The most commonly attributed causes of injury were improper form (33.3%) and exacerbation of a previous injury (33.3%). Twenty-five (64.1%) of those who experienced injury reported 1 month or less of training reduction due to the injury. Conclusion: Shoulder injury rates during CrossFit training are comparable to other methods of recreational exercise. Clinical Relevance: Clinicians should be aware of training demands of exercises in CrossFit and modifications for these exercises to safely progress their patients back to participation.
The Financial and Professional Impact of Anterior Cruciate Ligament Injuries in National Football League Athletes
Authors: Secrist Eric S. , Bhat Suneel B. , Dodson Christopher C. 
Published: August 2016

Background: Anterior cruciate ligament (ACL) injuries can have negative consequences on the careers of National Football League (NFL) players, however no study has ever analyzed the financial impact of these injuries in this population. Purpose: To quantify the impact of ACL injuries on salary and career length in NFL athletes. Study Design: Cohort study; Level of evidence, 3. Methods: Any player in the NFL suffering an ACL injury from 2010 to 2013 was identified using a comprehensive online search. A database of NFL player salaries was used to conduct a matched cohort analysis comparing ACL-injured players with the rest of the NFL. The main outcomes were the percentage of players remaining in the NFL and mean salary at 1, 2, 3, and 4 years after injury. Cohorts were subdivided based on initial salary: group A, <$500,000; group B, ≤$500,000 to $2,000,000; and group C, >$2,000,000. Mean cumulative earnings were calculated by multiplying the percentage of players remaining in the league by their mean salaries and compounding this each season. Results: NFL athletes suffered 219 ACL injuries from 2010 to 2013. The 7504 other player seasons in the NFL during this time were used as controls. Significantly fewer ACL-injured players than controls remained in the NFL at each time point ( P < .05). In group A, significantly less ACL-injured players remained in the NFL at 1 to 3 seasons after injury ( P < .05), and in group B, significantly less ACL-injured players remained in the NFL at 1 and 2 seasons after injury ( P < .05). There was no significant decrease in group C. Players in groups A and B remaining in the NFL also had a lower mean salary than controls ( P < .05 in season 1). The mean cumulative earnings over 4 years for ACL-injured players was $2,070,521 less per player than uninjured controls. Conclusion: On average, ACL-injured players earned $2,070,521 less than salary-matched controls over the 4 years after injury. Players initially earning less than $2 million per year have lower mean salaries and are less likely to remain in the league than uninjured controls. The careers of players initially earning over $2 million per year, meanwhile, are not negatively affected. This demonstrates the degree of negative impact these injuries have on the careers of NFL players. It also indicates that a player’s standing within the league before injury strongly influences how much an ACL injury will affect his career.
How many stroke patients might be eligible for mechanical thrombectomy?
Authors: Tawil Salwa El , Cheripelli Bharath , Huang Xuya , Moreton Fiona , Kalladka Dheeraj , MacDougal Niall JJ , McVerry Ferghal , Muir Keith W 
Published: August 2016

Introduction Recent studies showed improved patient outcomes with endovascular treatment of acute stroke compared to medical care, including IV rtPA, alone. Seven trials have reported results, each using different clinical and imaging criteria for patient selection. We compared eligibility for different trial protocols to estimate the number of patients eligible for treatment. Patients and methods Patient data were extracted from a single centre database that combined patients recruited to three clinical studies, each of which obtained both CTA and CTP within 6 h of stroke onset. The published inclusion and exclusion criteria of seven intervention trials (MR CLEAN, EXTEND–IA, ESCAPE, SWIFT-PRIME, REVASCAT, THERAPY and THRACE) were applied to determine the proportion that would be eligible for each of these studies. Results A total of 263 patients was included. Eligibility for IAT in individual trials ranged from 53% to 3% of patients; 17% were eligible for four trials and under 10% for two trials. Only three patients (1%) were eligible for all studies. The most common cause of exclusion was absence of large artery occlusion (LAO) on CTA. When applying simplified criteria requiring an ASPECT score > 6, 16% were eligible for IAT, but potentially 40% of these patients were excluded by perfusion criteria and more than half by common NIHSS thresholds. Conclusion Around 15% of patients presenting within 6 h of stroke onset were potentially eligible for IAT, but clinical trial eligibility criteria have much more limited overlap than is commonly assumed and only 1% of patients fulfilled criteria for all recent trials.
inv(16) and NPM1mut AMLs engraft human cytokine knock-in mice
Authors: Ellegast Jana M. , Rauch Philipp J. , Kovtonyuk Larisa V. , Müller Rouven , Wagner Ulrich , Saito Yasuyuki , Wildner-Verhey van Wijk Nicole , Fritz Christine , Rafiei Anahita , Lysenko Veronika , Dudkiewicz Ewa , Theocharides Alexandre P. , Soldini Davide , Goede Jeroen S. , Flavell Richard A. , Manz Markus G. 
Published: August 2016

Key Points
Humanized cytokine KI mice support engraftment of human favorable-risk AML. Engraftment and gene-enrichment analysis suggest M-CSF dependency of inv(16) AML.
Access to Care in Vermont: Factors Linked With Time to Chemotherapy for Women With Breast Cancer—A Retrospective Cohort Study
Authors: Johnson Ali , Shulman Leanne , Kachajian Jennifer , Sprague Brian L. , Khan Farrah , James Ted , Cranmer David , Young Peter , Heimann Ruth 
Published: August 2016

Purpose: In the rural United States, there are multiple potential barriers to the timely initiation of chemotherapy. The goal of this study was to identify factors associated with delays in the time from initial diagnosis to first systemic therapy (TTC) among women with breast cancer in Vermont. Methods: Using data from the Vermont Cancer Registry, we explored TTC for 702 female Vermont residents diagnosed with stage I to III breast cancer between 2006 and 2010 who received adjuvant chemotherapy. Multivariable linear regression was used to evaluate the associations between TTC and patient, tumor, treatment, and geographic variables. Results: Mean TTC was 10.2 weeks. Longer drive time (P < .001), more invasive surgery (P = .01), and breast reconstruction (P < .001) were each associated with longer TTC. Each additional 15 minutes of drive time was associated with a 0.34-week (95% CI, 0.22 to 0.46 weeks) increase in TTC. Participants age younger than 65 years whose primary payer was Medicare (n = 27) had significantly longer average TTC, by 2.37 weeks (P = .001), compared with those with private or military insurance. There was also substantial variation in TTC across hospitals (P < .001). Conclusion: Most female patients with stage I to III breast cancer in Vermont are receiving adjuvant chemotherapy within the National Comprehensive Cancer Network–recommended timeframe; however, improvements remain needed for certain subgroups. Novel approaches for women with long drive times need to be developed and evaluated in the community. Variation in TTC by hospital, even after adjusting for patient, tumor, and treatment factors, also suggests opportunities for process improvement.
Increased fat catabolism sustains water balance during fasting in zebra finches
Authors: Rutkowska Joanna , Sadowska Edyta T. , Cichoń Mariusz , Bauchinger Ulf 
Published: August 2016

ABSTRACTPatterns of physiological flexibility in response to fasting are well established, but much less is known about the contribution of water deprivation to the observed effects. We investigated body composition and energy and water budget in three groups of zebra finches: birds with access to food and water, food-deprived birds having access to drinking water and food-and-water-deprived birds. Animals were not stimulated by elevated energy expenditure and they were in thermoneutral conditions; thus, based on previous studies, water balance of fasting birds was expected to be maintained by increased catabolism of proteins. In contrast to this expectation, we found that access to water did not prevent reduction of proteinaceous tissue, but it saved fat reserves of the fasting birds. Thus, water balance of birds fasting without access to water seemed to be maintained by elevated fat catabolism, which generated 6 times more metabolic water compared with that in birds that had access to water. Therefore, we revise currently established views and propose fat to serve as the primary source for metabolic water production. Previously assumed increased protein breakdown for maintenance of water budget would occur if fat stores were depleted or if fat catabolism reached its upper limits due to high energy demands.
Effects of support diameter and compliance on common marmoset (Callithrix jacchus) gait kinematics
Authors: Young Jesse W. , Stricklen Bethany M. , Chadwell Brad A. 
Published: August 2016

ABSTRACTLocomotion is precarious in an arboreal habitat, where supports can vary in both diameter and level of compliance. Several previous studies have evaluated the influence of substrate diameter on the locomotor performance of arboreal quadrupeds. The influence of substrate compliance, however, has been mostly unexamined. Here, we used a multifactorial experimental design to investigate how perturbations in both diameter and compliance affect the gait kinematics of marmosets (Callithrix jacchus; N=2) moving over simulated arboreal substrates. We used 3D-calibrated video to quantify marmoset locomotion over a horizontal trackway consisting of variably sized poles (5, 2.5 and 1.25 cm in diameter), analyzing a total of 120 strides. The central portion of the trackway was either immobile or mounted on compliant foam blocks, depending on condition. We found that narrowing diameter and increasing compliance were both associated with relatively longer substrate contact durations, though adjustments to diameter were often inconsistent relative to compliance-related adjustments. Marmosets also responded to narrowing diameter by reducing speed, flattening center of mass (CoM) movements and dampening support displacement on the compliant substrate. For the subset of strides on the compliant support, we found that speed, contact duration and CoM amplitude explained &gt;60% of the variation in substrate displacement over a stride, suggesting a direct performance advantage to these kinematic adjustments. Overall, our results show that compliant substrates can exert a significant influence on gait kinematics. Substrate compliance, and not just support diameter, should be considered a critical environmental variable when evaluating locomotor performance in arboreal quadrupeds.
Predictors and brain connectivity changes associated with arm motor function improvement from intensive robotic practice in chronic stroke
Authors: Wittenberg George F. , Richards Lorie G. , Jones-Lush Lauren M. , Roys Steven R. , Gullapalli Rao P. , Yang Suzy , Guarino Peter D. , Lo Albert C. 
Published: August 2016

Background and Purpose: The brain changes that underlie therapy-induced improvement in motor function after stroke remain obscure. This study sought to demonstrate the feasibility and utility of measuring motor system physiology in a clinical trial of intensive upper extremity rehabilitation in chronic stroke-related hemiparesis. Methods: This was a substudy of two multi-center clinical trials of intensive robotic arm therapy in chronic, significantly hemiparetic, stroke patients. Transcranial magnetic stimulation was used to measure motor cortical output to the biceps and extensor digitorum communus muscles. Magnetic resonance imaging (MRI) was used to determine the cortical anatomy, as well as to measure fractional anisotropy, and blood oxygenation (BOLD) during an eyes-closed rest state. Region-of-interest time-series correlation analysis was performed on the BOLD signal to determine interregional connectivity. Functional status was measured with the upper extremity Fugl-Meyer and Wolf Motor Function Test. Results: Motor evoked potential (MEP) presence was associated with better functional outcomes, but the effect was not significant when considering baseline impairment. Affected side internal capsule fractional anisotropy was associated with better function at baseline. Affected side primary motor cortex (M1) activity became more correlated with other frontal motor regions after treatment. Resting state connectivity between affected hemisphere M1 and dorsal premotor area (PMAd) predicted recovery. Conclusions: Presence of motor evoked potentials in the affected motor cortex and its functional connectivity with PMAd may be useful in predicting recovery. Functional connectivity in the motor network shows a trends towards increasing after intensive robotic or non-robotic arm therapy. Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifiers: CT00372411 & NCT00333983.
Predicting Outcomes of Hormone and Chemotherapy in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) Study by Biochemically-inspired Machine Learning
Authors: Rezaeian Iman , Mucaki Eliseos J. , Baranova Katherina , Pham Huy Q. , Angelov Dimo , Ngom Alioune , Rueda Luis , Rogan Peter K. 
Published: August 2016

Genomic aberrations and gene expression-defined subtypes in the large METABRIC patient cohort have been used to stratify and predict survival. The present study used normalized gene expression signatures of paclitaxel drug response to predict outcome for different survival times in METABRIC patients receiving hormone (HT) and, in some cases, chemotherapy (CT) agents. This machine learning method, which distinguishes sensitivity vs. resistance in breast cancer cell lines and validates predictions in patients, was also used to derive gene signatures of other HT (tamoxifen) and CT agents (methotrexate, epirubicin, doxorubicin, and 5-fluorouracil) used in METABRIC. Paclitaxel gene signatures exhibited the best performance, however the other agents also predicted survival with acceptable accuracies. A support vector machine (SVM) model of paclitaxel response containing the ABCB1, ABCB11, ABCC1, ABCC10, BAD, BBC3, BCL2, BCL2L1, BMF, CYP2C8, CYP3A4, MAP2, MAP4, MAPT, NR1I2, SLCO1B3, TUBB1, TUBB4A, TUBB4B genes was 78.6% accurate in 84 patients treated with both HT and CT (median survival ≥ 4.4 yr). Accuracy was lower (73.4%) in 304 untreated patients. The performance of other machine learning approaches were also evaluated at different survival thresholds. Minimum redundancy maximum relevance feature selection of a paclitaxel-based SVM classifier based on expression of ABCB11, ABCC1, BAD, BBC3 and BCL2L1 was 79% accurate in 53 CT patients. A random forest (RF) classifier produced a gene signature (ABCB11, ABCC1, BAD, BCL2, CYP2C8, CYP3A4, MAP4, MAPT, NR1I2, TUBB1, GBP1, OPRK1) that predicted >3 year survival with 82.4% accuracy in 420 HT patients. A similar RF gene signature showed 79.6% accuracy in 504 patients treated with CT and/or HT. These results suggest that tumor gene expression signatures refined by machine learning techniques can be useful for predicting survival after drug therapies.
Predators of the Alfalfa Aphids Acyrthosiphon pisum (Harris), Aphis craccivora Koch, and Therioaphis trifolii (Monell) (Hemiptera: Aphidoidea) as Determined by the Serological Technique
Authors: Cunha Suzan Beatriz Zambon da , Sousa e Silva Carlos Roberto , Diniz Flávio Henrique Góis , Berti-Filho Evôneo 
Published: August 2016

Predators of the Alfalfa Aphids Acyrthosiphon pisum (Harris), Aphis craccivora Koch,and Therioaphis trifolii (Monell) (Hemiptera: Aphidoidea) as Determined by the Serological TechniqueAbstract. The serology is an immunological technique based on antigen/antibody reactions in where its main advantages are high sensitivity and specificity that allows the biological recognition at the molecular level. This study evaluates the use of serology technique to determine the predators of the alfalfa aphids Acyrthosiphon pisum (Harris), Aphis craccivora Koch,and Therioaphis trifolii (Monell)(Hemiptera: Aphidoidea). The aphid samplings to obtain the antibodies and their possible predators to be used as antigens were carried out in the alfalfa fields of the Embrapa Pecuária Sudeste Unit, São Carlos, SP. In the period from August 2011 to July 2012. A total of 2,161 arthropod predators, including insects and spiders, were tested. The antibodies obtained for the aphid A. craccivora, A. pisum, and T. trifolii showed partial identity nevertheless still allowed to recognize the predators of alfalfa aphids. Among the insects, syrphids and chrysopids presented the highest percentage of positive results in the serological tests. The species A. craccivora was the most preyed aphid.Determinação de Predadores dos Pulgões da Alfafa Acyrthosiphon pisum (Harris), Aphis craccivora Koch e Therioaphis trifolii (Monell)(Hemiptera: Aphidoidea) por meio da Técnica SerológicaResumo. A serologia é uma técnica imunológica baseada em reações antígeno/anticorpo, em que suas principais vantagens são a alta sensibilidade e especificidade que permitem o reconhecimento biológico em nível molecular. Este trabalho avalia o uso da técnica serológica para determinar os predadores dos pulgões da alfafa, Acyrthosiphon pisum (Harris), Aphis craccivora Koch e Therioaphis trifolii (Monell) (Hemiptera: Aphidoidea). As coletas dos pulgões para a obtenção dos anticorpos e de seus possíveis predadores para serem utilizados como antígenos foram realizadas nos campos de alfafa da Unidade da Embrapa Pecuária Sudeste, São Carlos, SP. no período de agosto de 2011 a julho de 2012. Foram testados 2.161 artrópodes predadores, incluindo insetos e aranhas. Os anticorpos obtidos para os pulgões A. craccivora, A. pisum, e T. trifolii mostraram identidade parcial mas, ainda assim, permitiu reconhecer os predadores dos pulgões da alfafa. Dentre os insetos, sirfídeos e crisopídeos foram os que apresentaram as maiores porcentagens de resultados positivos nos testes serológicos. A. craccivora foi o afídeo mais consumido pelos predadores.