bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comparison between SALT/SAAO observations and kilonova models for AT 2017gfo: the first electromagnetic counterpart of a gravitational wave transient − GW170817
Authors: Buckley David A H , Andreoni Igor , Barway Sudhanshu , Cooke Jeff , Crawford Steven M , Gorbovskoy Evgeny , Gromadzki Mariusz , Lipunov Vladimir , Mao Jirong , Potter Stephen B , Pretorius Magaretha L , Pritchard Tyler A , Romero-Colmenero Encarni , Shara Michael M , Väisänen Petri , Williams Ted B 
Published: December 2017

Abstract
We report on SALT low-resolution optical spectroscopy and optical/IR photometry undertaken with other SAAO telescopes (MASTER-SAAO and IRSF) of the kilonova AT 2017gfo (a.k.a. SSS17a) in the galaxy NGC4993 during the first 10 d of discovery. This event has been identified as the first ever electromagnetic counterpart of a gravitational wave event, namely GW170817, which was detected by the LIGO and Virgo gravitational wave observatories. The event is likely due to a merger of two neutron stars, resulting in a kilonova explosion. SALT was the third observatory to obtain spectroscopy of AT 2017gfo and the first spectrum, 1.2 d after the merger, is quite blue and shows some broad features, but no identifiable spectral lines and becomes redder by the second night. We compare the spectral and photometric evolution with recent kilonova simulations and conclude that they are in qualitative agreement for post-merger wind models with proton:nucleon ratios of Ye = 0.25–0.30. The blue colour of the first spectrum is consistent with the lower opacity of the lanthanide-free r-process elements in the ejecta. Differences between the models and observations are likely due to the choice of system parameters combined with the absence of atomic data for more elements in the ejecta models.
Detection of periodicity based on independence tests – III. Phase distance correlation periodogram
Authors: Zucker Shay 
Published: December 2017

Abstract
I present the Phase Distance Correlation (PDC) periodogram – a new periodicity metric, based on the Distance Correlation concept of Gábor Székely. For each trial period, PDC calculates the distance correlation between the data samples and their phases. PDC requires adaptation of the Székely’s distance correlation to circular variables (phases). The resulting periodicity metric is best suited to sparse data sets, and it performs better than other methods for sawtooth-like periodicities. These include Cepheid and RR-Lyrae light curves, as well as radial velocity curves of eccentric spectroscopic binaries. The performance of the PDC periodogram in other contexts is almost as good as that of the Generalized Lomb–Scargle periodogram. The concept of phase distance correlation can be adapted also to astrometric data, and it has the potential to be suitable also for large evenly spaced data sets, after some algorithmic perfection.
Spontaneous Microguidewire Extrusion From the Foot Following Cerebral Aneurysm Treatment: First Case Report
Authors: Nader Kurdow , Lamin Saleh , Leyon Joseph , Chavda Swarupsinh , Thomas Allan , Kuruvath Sarin 
Published: December 2017

Abstract

BACKGROUND AND IMPORTANCE
Microguidewire entrapment and failure related to endovascular therapy is a rare complication with limited case reports available, most of which are from cardiac endovascular intervention. Migration of the microguidewire has been reported in coronary intervention with some resulting in severe complications, but there are no reported cases of spontaneous extrusion of wire fragment following a neurointerventional procedure. We report the first case of a microguidewire entrapment with subsequent fracture, followed by spontaneous extrusion of the wire fragment.

CLINICAL PRESENTATION
A 40-yr-old woman was admitted for an elective flow-diversion stent treatment of an unruptured paraophthalamic aneurysm. Microguidewire entrapment occurred during an attempted balloon-aided dilatation of the partially opened stent. Careful attempts failed to retrieve the wire; hence, the decision was made to leave it behind. She presented to her family doctor 6 mo later with spontaneous extrusion of a 60-cm fragment of the retained wire, from her heel ipsilateral to the femoral puncture site. This had not resulted in any further vascular or non-vascular complications.

CONCLUSION
Fracture with extrusion is a potential consequence of a retained microguidewires. While this is an extremely rare complication, it is important to alert clinicians and patient about the possibility of wire migration and extrusion. Early follow-up with clinical assessment, and targeted imaging should lead to identification of this occurrence.
Early Cyclical Neuromuscular Electrical Stimulation Improves Strength and Trophism by Akt Pathway Signaling in Partially Paralyzed Biceps Muscle After Spinal Cord Injury in Rats
Authors: de Freitas Gabriel R , Santo Caroline C do Espírito , de Machado-Pereira Nicolas A M M , Bobinski Franciane , dos Santos Adair R S , Ilha Jocemar 
Published: December 2017

Abstract

Background
Electrical stimulation is often used to treat weakness in people with spinal cord injury (SCI); however its efficacy for increasing strength and trophism is weak, and the mechanisms underlying the therapeutic benefits are unknown.

Objective
The purpose of this study was to analyze the effects of neuromuscular electrical stimulation (NMES) on muscle function, trophism, and the Akt pathway signaling involved in muscular plasticity after incomplete SCI in rats.

Design
This was an experimental study.

Methods
Twenty-one adult female Wistar rats were divided into sham, SCI, and SCI plus NMES groups. In injured animals, SCI hemisection was induced by a surgical procedure at the C5-C7 level. The 5-week NMES protocol consisted of biceps brachii muscle stimulation 5 times per week, initiated 48 h after injury. Forepaw function and strength, biceps muscle trophism, and the expression of phosphorylated Akt, p70S6K, and GSK-3ß cellular anabolic pathway markers in stimulated muscle tissue were assessed.

Results
There was an increase in bicep muscle strength in the NMES group compared with the untreated SCI group, from postoperative day 21 until the end of the evaluation period. Also, there was an increase in muscle trophism in the NMES group compared with the SCI group. Forelimb function gradually recovered in both the SCI group and the NMES group, with no differences between them. Regarding muscle protein expression, the NMES group had higher values for phospho-Akt, phospho-p70S6K, and phospho-GSK-3ß than did the SCI group.

Limitations
The experimental findings were limited to an animal model of incomplete SCI and may not be fully generalizable to humans.

Conclusions
Early cyclical NMES therapy was shown to increase muscle strength and induce hypertrophy after incomplete SCI in a rat model, probably by increasing phospho-Akt, phospho-p70S6K, and phospho-GSK-3ß signaling protein synthesis.
Continuous Infusion of Low-Dose Iohexol Measures Changing Glomerular Filtration Rate in Critically Ill Patients
Authors: Dixon John J. , Lane Katie , Dalton R. Neil , Turner Charles , MacPhee Iain A. M. , Chis Ster Irina , Philips Barbara J. 
Published: December 2017

Objective:
Measurement of changing glomerular filtration rate in acute kidney injury remains problematic. We have previously used a continuous infusion of low-dose Iohexol to measure glomerular filtration rate in stable subjects and postulate that changes greater than 10.3% in critically ill patients indicate acute kidney injury. Our objective is to explore the extent to which continuous infusion of low-dose Iohexol can be a measure of changing glomerular filtration rate during acute kidney injury.

Design:
Clinical observational exploratory study.

Setting:
Adult ICU.

Patients:
Three patient groups were recruited: nephrectomy group: predictable onset of acute kidney injury and outcome (n = 10); surgery group: predictable onset of acute kidney injury, unpredictable outcome (n = 11); and acute kidney injury group: unpredictable onset of acute kidney injury and outcome (n = 13).

Interventions:
Continuous infusion of low-dose Iohexol was administered for 24–80 hours. Plasma (ClP) and renal (ClR) Iohexol clearances were measured at timed intervals.

Measurements and Main Results:
Kidney Disease: Improved Global Outcomes acute kidney injury criteria were fulfilled in 22 patients (nephrectomy = 5, surgery = 4, and acute kidney injury = 13); continuous infusion of low-dose Iohexol demonstrated acute kidney injury in 29 patients (nephrectomy = 10, surgery = 8, acute kidney injury = 11). Dynamic changes in glomerular filtration rate were tracked in all patients. In the nephrectomy group, ClR decreased by an expected 50% (50.8% ± 11.0%). Agreement between ClP and ClR improved with increasing duration of infusion: bias of ClP versus ClR at 48 hours was –0.1 ± 3.6 mL/min/1.73 m2 (limits of agreement: –7.2 to 7.1 mL/min/1.73 m2). Coefficient of variation of laboratory sample analysis was 2.4%.

Conclusions:
Continuous infusion of low-dose Iohexol is accurate and precise when measuring glomerular filtration rate and tracks changes in patients with differing risks of acute kidney injury. Continuous infusion of low-dose Iohexol may provide a useful standard against which to test novel biomarkers for the diagnosis of acute kidney injury.
Structural and functional abnormalities of the insular cortex in trigeminal neuralgia: a multimodal magnetic resonance imaging analysis
Authors: Wang Yue , Zhang Yuanchao , Zhang Jinlei , Wang Jiaojian , Xu Jinping , Li Jie , Cui Gaoyu , Zhang Jiuquan 
Published: December 2017

Abstract
Trigeminal neuralgia (TN) is a chronic neuropathic pain disorder characterized by intense, lancinating attacks of facial pain. Increasing evidence suggests that TN is accompanied by abnormalities in brain morphology, white matter microstructure, and function. However, whether these abnormalities are linked or reflect independent etiologies remains unknown. Using multimodal magnetic resonance imaging data of 20 patients with TN and 21 healthy controls, we investigated cortical gyrification abnormalities, their relationships with abnormalities of the underlying white matter microstructure and gray matter morphology, as well as their functional significance in TN. Compared with controls, patients with TN showed significant local gyrification index (LGI) reductions predominantly in the left insular cortex, which were negatively correlated with pain intensity. In this cluster, patients with TN had concurrent cortical thickness reductions but unaltered cortical surface area. Meanwhile, LGI of this cluster was not correlated with overlying cortical thickness or surface area but was positively correlated with the fractional anisotropy of 2 nearby white matter clusters, suggesting that insular LGI reductions may be primarily driven by microstructural abnormalities of the underlying white matter tracts, rather than by abnormalities in cortical thickness and surface area. In addition, patients with TN exhibited increased insula functional connectivity to the left posterior cingulate cortex and thalamus, which was positively correlated with disease duration. These findings provide new evidence for the involvement of insular abnormalities in the pathophysiology of TN.
Coronal CT is Comparable to MR Imaging in Aiding Diagnosis of Dementia in a Memory Clinic in Singapore
Authors: Thiagarajan Sasinthiran , Shaik Muhammad A. , Venketasubramanian Narayanaswamy , Ting Eric Y.S. , Hilal Saima , Chen Christopher 
Published: December 2017

Purpose:
The present study investigated (a) the agreement between computerized tomography (CT) and 3 T magnetic resonance imaging (MRI) in the visual grading of medial temporal atrophy (MTA); and (b) whether MTA on CT differentiated patients with dementia from no dementia in memory clinics.

Materials and Methods:
Data were obtained from patients who underwent CT scans at the National University Hospital of Singapore, and from a subsample who subsequently underwent 3 T MRI scans in a research study. Agreements and disagreements between CT and MRI were determined. Area under the curve (AUC) analyses determined if CT-graded MTA distinguished patients with dementia from no dementia.

Results:
Of the 107 patients in the subsample, MTA scores of 71 agreed on both CT and MRI. The true positive rate between CT and MRI for MTA scores ≥2 was 79.7%. The true negative rate for MTA scores between 0 and 1 was 96.4%. CT underestimated MTA severity in 33 of 36 disagreements with the MRI. MTA scores ≥2 on CT distinguished dementia from no dementia in both discovery [n=263; AUC (95% confidence interval)=0.77 (0.72-0.83); sensitivity=0.69; specificity=0.74] and validation [n=264; AUC (95% confidence interval)=0.77 (0.71-0.82); sensitivity=0.72; specificity=0.72] groups.

Conclusions:
MTA graded on CT is a viable alternative to MRI to aid in the diagnosis of dementia in memory clinics.
Introgression of a block of genome under infinitesimal selection
Authors: Sachdeva Himani , Barton Nicholas H. 
Published: December 2017

AbstractAdaptive introgression is common in nature and can be driven by selection acting on multiple, linked genes. We explore the effects of polygenic selection on introgression under the infinitesimal model with linkage. This model assumes that the introgressing block has an effectively infinite number of genes, each with an infinitesimal effect on the trait under selection. The block is assumed to introgress under directional selection within a native population that is genetically homogeneous. We use individual-based simulations and a branching process approximation to compute various statistics of the introgressing block, and explore how these depend on parameters such as the map length and initial trait value associated with the introgressing block, the genetic variability along the block, and the strength of selection. Our results show that the introgression dynamics of a block under infinitesimal selection is qualitatively different from the dynamics of neutral introgression. We also find that in the long run, surviving descendant blocks are likely to have intermediate lengths, and clarify how the length is shaped by the interplay between linkage and infinitesimal selection. Our results suggest that it may be difficult to distinguish introgression of single loci from that of genomic blocks with multiple, tightly linked and weakly selected loci.
A rhamnose-inducible system for precise and temporal control of gene expression in cyanobacteria
Authors: Kelly Ciarán L. , Hitchcock Andrew , Torres-Méndez Antonio , Heap John T. 
Published: December 2017

ABSTRACTCyanobacteria are important for fundamental studies of photosynthesis and have great biotechnological potential. In order to better study and fully exploit these organisms, the limited repertoire of genetic tools and parts must be expanded. A small number of inducible promoters have been used in cyanobacteria, allowing dynamic external control of gene expression through the addition of specific inducer molecules. However, the inducible promoters used to date suffer from various drawbacks including toxicity of inducers, leaky expression in the absence of inducer and inducer photolability, the latter being particularly relevant to cyanobacteria which, as photoautotrophs, are grown under light. Here we introduce the rhamnose-induciblerhaBADpromoter ofEscherichia coliinto the model freshwater cyanobacteriumSynechocystissp. PCC 6803 and demonstrate it has superior properties to previously reported cyanobacterial inducible promoter systems, such as a non-toxic, photostable, non-metabolizable inducer, a linear response to inducer concentration and crucially no basal transcription in the absence of inducer.
Municipal tax structure and accounting disclosure
Authors: Sanders George D. , Ingram Robert W. 
Published: December 2017

Two competing hypotheses have been developed in the public economics literature to explain the growth of government spending. The first, termed the fiscal illusion hypothesis, holds that governments have incentives to induce a misperception in the population about the cost of government. By constructing complex systems of taxation that obscure the true cost of government services, governments can lead the taxpayer to demand a larger quantity of services. The other hypothesis, the fiscal stress hypothesis, holds that tax complexity diversifies revenues, leading to less revenue variability and, hence, lower costs. Taxpayers, then, demand more government services. The two hypotheses make very different assumptions about the incentives of governments in regard to an informed electorate. The fiscal illusion hypothesis suggests incentives to obscure information, while the fiscal stress hypothesis suggests incentives to reveal true costs.Accounting and financial reporting can play a role in revealing fiscal information to taxpayers, directly or indirectly, through information intermediaries. If the fiscal illusion hypothesis describes the behavior of governments, we would expect that such governments would attempt to protect the information advantage that is conveyed by a complex tax structure by minimizing accounting disclosures. On the other hand, the fiscal illusion hypothesis suggests that a government with a complex tax structure has no reason to minimize disclosure, and may have incentives publicize lower service costs.This study examines the association of tax complexity and financial disclosure. We find that there is more disclosure in cities with more complex tax systems, a result that supports the fiscal stress hypothesis.
The gamification of trust: the case of China’s “social credit”
Authors: Ramadan Zahy 
Published: December 2017

PurposeChina is establishing a social credit rating system with the aim to score the trust level of citizens. The scores will be based on an integrated database that includes a vast range of information sources, rating aspects like professional conduct, corruption, type of products bought, peers’ own scores and tax evasion. While this form of gamification is expected to have dire consequences on brands and consumers alike, the literature in that particular area of interest remains non-existent. The paper aims to discuss these issues.Design/methodology/approachA conceptual framework is suggested that highlights early on the risks and implications on brands and companies operating in that particular upcoming landscape.FindingsThe gamification of trust that the social credit system focuses on presents potential risks on brand and consumer relationships. This in turn will affect brand sustainabilityvis-à-visthe expected drastic changes in the Chinese business landscape. This study suggests the strategies to follow which will be of high interest to companies, consumers, as well as to the Chinese authorities during and after implementation stage.Originality/valueThis paper is amongst the first to discuss the potential effects of the Chinese social credit rating system on brands. The conceptual framework fills a sizeable gap in the literature and pioneers the discussion on potential dilemmas brands will be faced with within this new business landscape.
Recent development of SPR spectroscopy as potential method for diagnosis of dengue virus E-protein
Authors: Omar Nur Alia Sheh , Fen Yap Wing 
Published: December 2017

Purpose
This paper aims to review the potential application of surface plasmon resonance (SPR) in diagnosis of dengue virus (DENV-2) E-protein and the development of SPR to become an alternative DENV sensor.

Design/methodology/approach
In this review, the existing standard laboratory techniques to diagnosis of DENV are discussed, together with their drawbacks. To overcome these drawbacks, SPR has been aimed to be a valuable optical biosensor for identification of antibodies to the DENV antigen. The review also includes the future studies on three-dimensional poly(amidoamine) (PAMAM) dendrimer-surface-assembled monolayer (SAM)-Au multilayer thin films, which are envisaged to have high potential sensitive and selective detection ability toward target E-proteins.

Findings
Application of SPR in diagnosis of DENV emerged over recent years. A wide range of immobilized biorecognition molecules have been developed to combine with SPR as an effective sensor. The detection limit, sensitivity and selectivity of SPR sensing in DENV have been enhanced from time to time, until the present.

Originality/value
The main purpose of this review is to provide authors with up-to-date and useful information on sensing DENV using SPR and to introduce a novel three-dimensional PAMAM-SAM-Au multilayer thin films for future research on SPR sensing applications.
Cell‐cell recognition and social networking in bacteria
Authors: Troselj Vera , Cao Pengbo , Wall Daniel 
Published: December 2017

SummaryThe ability to recognize self and to recognize partnering cells allows microorganisms to build social networks that perform functions beyond the capabilities of the individual. In bacteria, recognition typically involves genetic determinants that provide cell surface receptors or diffusible signalling chemicals to identify proximal cells at the molecular level that can participate in cooperative processes. Social networks also rely on discriminating mechanisms to exclude competing cells from joining and exploiting their groups. In addition to their appropriate genotypes, cell‐cell recognition also requires compatible phenotypes, which vary according to environmental cues or exposures as well as stochastic processes that lead to heterogeneity and potential disharmony in the population. Understanding how bacteria identify their social partners and how they synchronize their behaviours to conduct multicellular functions is an expanding field of research. Here, we review recent progress in the field and contrast the various strategies used in recognition and behavioural networking.
100 Days of marine Synechococcus–Ruegeria pomeroyi interaction: A detailed analysis of the exoproteome
Authors: Kaur Amandeep , Hernandez‐Fernaud Juan R. , Aguilo‐Ferretjans Maria del Mar , Wellington Elizabeth M. , Christie‐Oleza Joseph A. 
Published: December 2017

SummaryMarine phototroph and heterotroph interactions are vital in maintaining the nutrient balance in the oceans as essential nutrients need to be rapidly cycled before sinking to aphotic layers. The aim of this study was to highlight the molecular mechanisms that drive these interactions. For this, we generated a detailed exoproteomic time‐course analysis of a 100‐day co‐culture between the model marine picocyanobacterium Synechococcus sp. WH7803 and the Roseobacter strain Ruegeria pomeroyi DSS‐3, both in nutrient‐enriched and natural oligotrophic seawater. The proteomic data showed a transition between the initial growth phase and stable‐state phase that, in the case of the heterotroph, was caused by a switch in motility attributed to organic matter availability. The phototroph adapted to seawater oligotrophy by reducing its selective leakiness, increasing the acquisition of essential nutrients and secreting conserved proteins of unknown function. We also report a surprisingly high abundance of extracellular superoxide dismutase produced by Synechococcus and a dynamic secretion of potential hydrolytic enzyme candidates used by the heterotroph to cleave organic groups and hydrolase polymeric organic matter produced by the cyanobacterium. The time course dataset we present here will become a reference for understanding the molecular processes underpinning marine phototroph‐heterotroph interactions.