bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fibromyalgia Among Patients With Chronic Migraine and Chronic Tension‐Type Headache: A Multicenter Prospective Cross‐Sectional Study
Authors: Cho Soo‐Jin , Sohn Jong‐Hee , Bae Jong Seok , Chu Min Kyung 
Published: September 2017

ObjectivesTo investigate the frequency and impact of fibromyalgia among patients with chronic migraine (CM) and chronic tension‐type headache (CTTH).BackgroundFibromyalgia (FM) is a common comorbidity in patients with chronic headaches. CM and CTTH are the two common types of chronic headaches.MethodsWe conducted a cross‐sectional study in neurology outpatient clinics of four university hospitals and selected first‐visit 136 patients with CM and 35 patients with CTTH. FM was assessed based on the 2010 American College of Rheumatology diagnostic criteria.ResultsThe frequency of FM was significantly higher among patients with CM when compared to those with CTTH (91/136 [66.9%] vs 9/35 [25.7%], P < .001). Logistic regression analyses revealed an increased odds ratio (OR) for FM for patients with CM when compared to those with CTTH after adjustment for age, sex, anxiety, depression, and insomnia (OR = 3.6, 95% confidence interval = 1.1‐11.4). Furthermore, CM patients with FM had higher scores in FM Impact Questionnaire compared to CTTH patients with FM (51.5 ± 16.3 vs 43.7 ± 18.7, P = .015). Comorbidity of FM was associated with increased frequency of photophobia, phonophobia, anxiety, depression, and insomnia among patients with CM. Such association was not noted among patients with CTTH.ConclusionFM based on 2010 American College of Rheumatology diagnostic criteria was more prevalent among patients with CM than those with CTTH. Some clinical features and comorbidities of CM varied with the presence of FM.
Epidemiology of Helicobacter pylori infection in asymptomatic schoolchildren in Bhutan
Authors: Wangda Sonam , Richter James M. , Kuenzang Pema , Wangchuk Kinley , Choden Tashi , Tenzin Karma , Malaty Hoda M. 
Published: September 2017

AbstractAimBhutan is a small mountainous country between Tibet and India with relatively homogenous population. According to the World Health Organization, gastric cancer is the most frequent cause of cancer death in Bhutan. This study examined the prevalence of Helicobacter pylori among children in Bhutan with emphasis on water source and living conditions.MethodsA cross‐sectional sero‐epidemiologic study was conducted among schoolchildren who attended public schools in Thimphu, Bhutan. Between 2015 and 2016, blood samples from schoolchildren were collected after obtaining an informed consent from the school management and the children's parents. Demographic information, parents’ education, family size living in the same household, and aspects of household environment including type of latrines, boiling drinking water were collected. All serum samples were tested for H. pylori immunoglobulin G (IgG) by commercial ELISA kits.ResultsThere were 327 children between 4 and 19 years of age participated, 44% boys, mean age = 13.6 ± 3 years. The overall prevalence of H. pylori was 66% with no difference between boys and girls (66 vs 64%, respectively), P = .42. H. pylori prevalence was 75% among both 4‐7 and 15‐19 years and not statically different from that of the 8‐10 or 11‐14 age groups (59% and 63%, respectively), P = .1. H. pylori prevalence was inversely correlated with the level of mother's education (70% vs 55%) for those without and with a college education, respectively (OR = 2.3; 95%CI = 0.9‐1.7), P = .08. The total number of people living in the same household did not correlate with H. pylori sero‐prevalence, but households had less than 3 children had lower prevalence than those with 3 or more children (62% vs 71%, respectively OR = 1.7, 95% CI = [1.0‐2.6], P = .05).ConclusionsH. pylori infection is prevalent among all age group children in Bhutan. The results suggest that transmission of H. pylori is related to personal care practices that directly correlate with the mothers’ education and crowded living condition with children. Our results are important to developing prevention strategies for gastric cancer in Bhutan.
Effect of biopsy site on detection of gastric cancer high‐risk groups by OLGA and OLGIM stages
Authors: Kim Young‐Il , Kook Myeong‐Cherl , Cho Soo‐Jeong , Lee Jong Yeul , Kim Chan Gyoo , Joo Jungnam , Choi Il Ju 
Published: September 2017

AbstractBackground/AimsThe operative link for gastritis assessment (OLGA) and operative link on gastric intestinal metaplasia assessment (OLGIM) staging systems are recommended to assess the severity of gastritis, but the optimal biopsy sites have not been clearly defined. We aimed to investigate whether the scoring of the OLGA and OLGIM stages was affected by the use of different biopsy sites.MethodsBetween 2014 and 2015, to determine OLGA and OLGIM stages, seven biopsy samples were obtained from the antrum (lesser and greater curvatures [LG] of the antrum and lesser curvature of the angle) and corpus (LG and anterior and posterior walls [AP]) in 247 patients diagnosed with gastritis, gastric adenoma, or adenocarcinoma. The OLGA and OLGIM stages were scored using four different protocols: antrum + angle + corpus LG, antrum + angle + corpus AP, antrum + corpus LG, and antrum + corpus AP. High‐risk group included patients who had OLGA or OLGIM stages III and IV.ResultsFor the OLGA stage, the angle + antrum + corpus LG protocol placed more patients in the high‐risk group (64.4%) than the angle + antrum + corpus AP (55.5%, P < .001), antrum+corpus LG (59.5%, P = .031), and antrum + corpus AP (47.8%, P < .001) protocols. Likewise, for the OLGIM stage, the angle + antrum + corpus LG protocol placed more patients in the high‐risk group (48.6%) than the angle + antrum + corpus AP (46.2%, P = .134), antrum + corpus LG (36.8%, P < .001), and antrum + corpus AP (37.2%, P < .001) protocols.ConclusionsTo prevent underestimation of OLGA and OLGIM stages, it is necessary to include an angle biopsy, and to obtain corpus biopsy specimens from lesser and greater curvature sites rather than from anterior and posterior wall sites.
Cervical and middle dorsal actinomycetomas from Guerrero State, Mexico
Authors: Estrada‐Chávez Guadalupe E. , Estrada Roberto , Fernandez Ramon , Arenas Roberto , Reyes Alain , Guevara Cindy , Chávez‐López Guadalupe 
Published: September 2017

AbstractBackgroundMycetomas are frequent subcutaneous mycoses with typical clinical characteristics such as sinuses, blood‐stained, serous, or purulent exudates as well as local swelling. Even though the most commonly affected areas are the lower limbs, we report four cases affecting the neck and midback regions, of which three were young females. We draw attention to the importance of early identification of these cases for prevention and specific treatment in order to avoid severe consequences or irreversible complications such as quadriplegia.ObjectiveTo document the occurrence of cervical spine and middle dorsal thoracic mycetomas, as well as their severity, clinical manifestations, and secondary complications.Material and MethodsThis was an observational and descriptive study in which we reviewed cases with neck and middle dorsal thoracic mycetomas diagnosed at the Acapulco General Hospital of Guerrero State, Mexico. We describe the cases including the mechanism of inoculation, neurological symptoms, and severity.ConclusionsWe describe three cases initially diagnosed clinically as cervical mycetomas and one in the middle dorsal thoracic region. All the cases were diagnosed at the Acapulco General Hospital of Guerrero State in Mexico.
An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non‐human primate neonates
Authors: Holbrook Beth C. , Aycock S. Tyler , Machiele Emily , Clemens Elene , Gries Danielle , Jorgensen Matthew J. , Hadimani Mallinath B. , King S. Bruce , Alexander‐Miller Martha A. 
Published: September 2017

SummaryImpaired immune responsiveness is a significant barrier to vaccination of neonates. By way of example, the low seroconversion observed following influenza vaccination has led to restriction of its use to infants over 6 months of age, leaving younger infants vulnerable to infection. Our previous studies using a non‐human primate neonate model demonstrated that the immune response elicited following vaccination with inactivated influenza virus could be robustly increased by inclusion of the Toll‐like receptor agonist flagellin or R848, either delivered individually or in combination. When delivered individually, R848 was found to be the more effective of the two. To gain insights into the mechanism through which these adjuvants functioned in vivo, we assessed the initiation of the immune response, i.e. at 24 hr, in the draining lymph node of neonate non‐human primates. Significant up‐regulation of co‐stimulatory molecules on dendritic cells could be detected, but only when both adjuvants were present. In contrast, R848 alone could increase the number of cells in the lymph node, presumably through enhanced recruitment, as well as B‐cell activation at this early time‐point. These changes were not observed with flagellin and the dual adjuvanted vaccine did not promote increases beyond those observed with R848 alone. In vitro studies showed that R848 could promote B‐cell activation, supporting a model wherein a direct effect on neonate B‐cell activation is an important component of the in vivo potency of R848 in neonates.
Subjective Probability Density Functions from FX Option Prices: Predictive Power and Performance on a Carry Trade Strategy
Authors: Santos André , Guerra João , Neves Tiago 
Published: September 2017

AbstractIn this article, we extracted the risk‐neutral densities (RNDs) and subjective probability density functions of the US Dollar/Brazilian Real (USD/BRL) exchange rate and evaluated its performance in predicting the future realizations of the USD/BRL exchange rate. The RNDs were estimated using two structural models and three nonstructural models. In the first category, we included the Variance Gamma‐OU model and the CGMY Gamma‐OU model. In the second category, we included the density functional based on confluent hypergeometric function model, the mixture of lognormal distributions model, and the smoothed implied volatility smile. The density functional based on confluent hypergeometric function and the CGMY Gamma‐OU produced 1‐month term densities (RND and subjective probability density function) with the highest forecasting power of the 1‐month USD/BRL exchange rate. Finally, we applied the CGMY Gamma‐OU model to extract a sample of subjective cumulative probabilities of 1‐month USD/BRL movements, and used them as explanatory variables in predictive time series models, whose dependent variable was the 1‐month carry trade return. Its predictive power was then tested and confirmed in three trading strategies that over performed the standard carry trade strategy in terms of annualized cumulative returns.
Structure, mechanical, and thermal properties of Ti1‐xAlxN/CrAlN (x = 0.48, 0.58, and 0.66) multilayered coatings
Authors: Liu Ziqiang , Chen Li , Xu Yuxiang 
Published: September 2017

AbstractNano‐multilayered TiAlN/CrAlN coatings combining advantages of Ti‐Al‐N and Cr‐Al‐N are considered to be promising candidates for advanced machining processes. Here, the structure and thermal properties of Ti1‐xAlxN/CrAlN (x = 0.48, 0.58, and 0.66) multilayered coatings as well as referential Ti1‐xAlxN and Cr0.32Al0.68N monolithic coatings were investigated. Ti1‐xAlxN coatings show a structural transformation from cubic structure for x = 0.48 to mixed cubic and wurtzite structure for x = 0.58 and 0.66, and Cr0.32Al0.68N coating exhibits a single cubic structure. Through a multilayer arrangement with Cr0.32Al0.68N layers, the Ti0.52Al0.48N and Ti0.42Al0.58N layers can be stabilized in their metastable cubic structure, but the Ti0.34Al0.66N layer still tends to crystallize in the mixed cubic and wurtzite structure. The hardness of Ti0.52Al0.48N/CrAlN and Ti0.42Al0.58N/CrAlN coatings is higher than that of corresponding monolithic coatings regardless of as‐deposited and annealed states. Especially, after annealing at 800°C, the Ti0.52Al0.48N/CrAlN and Ti0.42Al0.58N/CrAlN coatings reach their peak hardness of ~34.2 and 32.8 GPa due to the spinodal decomposition of Ti1‐xAlxN layers. However, the oxidation resistance of Ti1‐xAlxN/CrAlN coatings is mainly up to the Al content of Ti1‐xAlxN layers, where only the Ti0.34Al0.66N/CrAlN coating can survive the 10 h exposure to air at 1000°C.
Identification of electrocardiographic risk markers for the initial and recurrent episodes of ventricular fibrillation in patients with Brugada syndrome
Authors: Morita Hiroshi , Watanabe Atsuyuki , Kawada Satoshi , Miyamoto Masakazu , Morimoto Yoshimasa , Nakagawa Koji , Nishii Nobuhiro , Nakamura Kazufumi , Ito Hiroshi 
Published: September 2017

AbstractIntroductionNew onset of ventricular fibrillation (VF) in asymptomatic patients with Brugada‐type ECG is not frequent, but it cannot be negligible. Risk markers for predicting VF are usually based on results of analysis in symptomatic patients, and they have not been determined for asymptomatic patients. We analyzed ECG markers in patients with Brugada syndrome to differentiate the risk factors for VF in both symptomatic and asymptomatic patients.MethodsThe subjects were 471 patients with Brugada syndrome and we divided the subjects into two groups: Asymptomatic group (n = 326) and Symptomatic group (syncope: n = 122, VF: n = 23). We analyzed the following ECG markers: RR, PQ, QRS, QT and Tpeak‐Tend (Tpe) intervals, ST level, atrial fibrillation (AF), atrioventricular block, spontaneous type 1 ECG, early repolarization (ER) and fragmented QRS (fQRS).ResultsDuring follow‐up (91 ± 64 months), 41 patients experienced VF (Asymptomatic: n = 10, Symptomatic: n = 31). Univariable analysis showed that spontaneous type 1 ECG, Tpe interval (≥95 milliseconds), high ST level (≥0.52 mV) and fQRS were common predictors for VF in both the Asymptomatic and Symptomatic groups. In addition to the common risk factors, wide QRS (≥107 milliseconds), long QT interval (≥420 milliseconds), ER and AF were predictors for VF in Symptomatic group. Multivariable analysis of the Symptomatic group showed fQRS, Tpe and ER were independent predictors of prognosis.ConclusionsfQRS and Tpe interval are common risk factors for VF in both asymptomatic and symptomatic patients, whereas ER is a predictor for recurrent VF.
Long‐term follow‐up on patients treated for abdominal fat using a selective contactless radiofrequency device
Authors: Fritz Klaus , Salavastru Carmen 
Published: September 2017

SummaryBackground and objectiveThe aim of this study was to evaluate how abdominal circumferential reduction achieved after using a noninvasive radiofrequency device (BTL Vanquish, BTL Industries Inc., Boston, MA) evolves over a 4‐year period.MethodsThis is a follow‐up on patients who were treated in our practice for abdominal fat in an earlier published multicenter prospective study. Patients were recalled for biometric data collection 4 years (±60 days) after the last treatment. Body and weight measurements were compared to the historical data. Digital images of the treated area were taken. Independent panelists were asked to recognize the original baseline images from the 4‐year follow‐up images.ResultsThe evaluation encompasses 13 subjects. In the original study, these patients lost on average 5.88 ± 4.14 cm of waist circumference (P < .001) while losing on average 1.29 kg. After 4 years, the same subjects had an average reduction of 4.42 ± 2.85 cm (P < .001) compared to the baseline, while gaining on average 0.50 kg. In both cases, the waist change was statistically independent of the weight change (P < .01). The patients preserved on average 75.2% of the original body contouring effect after 4 years as measured by circumference. None of the patients grew in circumference when compared to the baseline. Reviewers recognized the baseline patient images from the follow‐up patient images in 82.1% cases. No long‐term side effects were observed that would relate to the treatments.ConclusionsIn the study group, patients with ordinary weight changes preserved most of the original waist reduction after 4 years.
Relationship between acne vulgaris and cosmetic usage in Sri Lankan urban adolescent females
Authors: Perera Magelage Prabhavi Nilupulee , Peiris Wadu Mesthrige Dilhani Mihiri , Pathmanathan Diranjala , Mallawaarachchi Sudaraka , Karunathilake Indika Mahesh 
Published: September 2017

SummaryBackgroundAcne vulgaris is one of the commonest skin disorders affecting up to 80% of the world population at least during adolescence. Significant psychosocial effects such as depression and poor personality development have been linked with acne, especially in female adolescents. Various causative factors, including cosmetic exposure, have been attributed toward acne.ObjectiveTo analyze the association between frequent exposure to cosmetics and severity of acne in adolescent females.MethodA cross‐sectional analytical study was performed on 140 girls from three schools in Colombo, Sri Lanka. A self‐administered questionnaire was utilized to assess the patterns of cosmetic usage. Grading acne of the participants was performed by the researchers utilizing a standard acne grading scale.ResultsThe overall prevalence of acne in our study population was 91.4% with a mean acne grade of 3.09. At least one cosmetic type was used by 126 (90%) of the population. A Pearson correlation coefficient (r) value of .452 (P < .001) was obtained between cosmetic exposure and acne grade, which indicates a statistically significant correlation. A chi‐square value of 22.875 was obtained at a degree of freedom of 2 (P < .001), enabling us to reject the null hypothesis that there is no significant association between cosmetic usage and acne severity.ConclusionOur results convey a significant positive association between frequent exposure to cosmetics and severity of acne in adolescent females. Girls of this age group must be made aware that cosmetic usage may be a potential aggravating factor for their facial acne.
The moderating role of age in the job characteristics–absenteeism relationship: A matter of occupational context?
Authors: Bouville Gregor , Dello Russo Silvia , Truxillo Donald 
Published: September 2017

This study addresses the relationship between job characteristics and sickness absenteeism, examining it under two important boundary conditions, employee age, and occupational group. Drawing from psychological theories that explain age‐related differences in the workplace, as well as the sociology of occupations, we formulate hypotheses concerning two‐ and three‐way interactions between five key job characteristics (job demands, autonomy, skill variety, supervisor, and colleague support), age, and occupational group, namely blue‐collar workers versus clerks. We test our hypotheses on an archival sample of 5,175 employees taken from the French National Survey of Employment Conditions. Hierarchical negative binomial regressions reveal that many of our hypotheses are supported. For example, autonomy and supervisor and colleague support have a differential impact on sickness absenteeism depending on age and the occupational group of employees. We discuss the implications of our findings for both theory and practice.Practitioner pointsSickness absences can be predicted by job characteristics as function of age and occupational groups.Supervisor support is associated with fewer sickness absences in younger workers, especially clerks.Occupational context may mask the age differences because for Job Autonomy and Colleague Support, age‐related differences were detected only within the blue‐collar and clerical groups, respectively.The impact of job demands and skill variety on sickness absences is moderated by age and does not vary across the two occupational groups.
Dynamic daily associations between insomnia symptoms and alcohol use in adults with chronic pain
Authors: Miller Mary Beth , Chan Wai Sze , Boissoneault Jeff , Robinson Michael , Staud Roland , Berry Richard B. , McCrae Christina S. 
Published: September 2017

SummaryIndividuals with chronic pain are at risk for sleep disruption and heavy alcohol use, yet the daily associations between these behaviours are not well characterized. This study aimed to determine the extent to which alcohol use affects insomnia symptoms and vice versa in adults reporting symptoms of chronic pain. Participants were 73 individuals (93% women) reporting alcohol use in addition to symptoms of insomnia and chronic pain. They completed daily diaries assessing insomnia symptoms and alcohol use for 14 days. Multilevel modelling was used to evaluate the bidirectional associations between alcohol use and insomnia symptoms at the daily level. Consistent with laboratory‐based research, alcohol use was associated with decreased sleep‐onset latency the same night but increased sleep‐onset latency 2 nights later. Specifically, for every alcoholic drink consumed, time to sleep onset decreased by 5.0 min in the same night but increased by 4.3 min 2 nights later. Alcohol use was not significantly associated with subsequent wake after sleep onset or total sleep time, and insomnia symptoms were not significantly associated with subsequent alcohol use. To our knowledge, these data provide the first evidence that alcohol use negatively affects insomnia symptoms up to 2 days post‐consumption in patients reporting symptoms of insomnia and chronic pain. Findings suggest that one drink will have minimal impact on sleep, but heavier drinking (e.g. four–five drinks) may have a clinically significant impact (16–25‐min increase in sleep‐onset latency). Future studies may assess alcohol use as a point of intervention within this population.