bluuebunny/crossref_metadata_2025_split huggingface dataset:
PERÓXIDO DE CARBAMIDA 37% NO CLAREAMENTO DENTÁRIO E SUA ATUAÇÃO NA EFETIVIDADE CLAREADORA E ELIMINAÇÃO DE SENSIBILIDADE: RELATO DE CASO
Authors: De Araújo Isabela Dantas Torres , Soares Gabriella Peixoto de Araújo , Araújo Laura Geissler Ramos Aladim de , De Assunção Isauremi Vieira 
Published: September 2024

Introdução: A sensibilidade dentária é o efeito adverso mais comum relacionado ao clareamento dentário. Na técnica de consultório, o peróxido de carbamida a 37%, surgiu como possibilidade de clarear e não causar sensibilidade. Objetivo: trata-se de um relato de caso, que avaliou a eficácia (mudança de cor) e a presença ou não de sensibilidade dentária quando fez-se o uso de um produto à base de peróxido de hidrogênio a 35% (PH) e outro de peróxido de carbamida a 37% (PC), na técnica de clareamento dentário de consultório. Relato de caso: Paciente de 25 anos, sexo masculino, submetido a estudo de boca dividida, onde no hemiarco esquerdo foi aplicado peróxido de hidrogênio a 35% e no hemiarco direito, peróxido de carbamida a 37%. Foram feitas 3 sessões, sendo PC com aplicação única de 45 minutos, e PH com 3 aplicações de 15 minutos, em seu respectivo lado de aplicação e intervalo de sete dias entre cada sessão. Os valores de sensibilidade foram analisados antes e depois de cada sessão por meio da escala visual analógica de dor, e a alteração de cor foi avaliada através da Escala Vita, analisando incisivos e caninos superiores, antes de cada sessão. Conclusões: O clareamento dental com o PH apresentou melhor eficácia clareadora e o PC apresentou ausência de sensibilidade durante o procedimento clareador. Sugerem-se mais estudos do tipo ensaio clínico, com o PC, para que se possa, com uma amostra maior de pacientes, verificar suas vantagens no quesito sensibilidade, bem como sua efetividade clareadora.
ESTUDO DAS DIFERENTES FORMAS DE TRATAMENTO PARA DISFUNÇÕES TEMPOROMANDIBULARES
Authors: Nascimento Lucas Mateus do , Chianca Rafaelly Domingos Campos de Souza , Silva Ricardo Felipe Ferreira da , Mendonça Luana da Rocha Alves 
Published: September 2024

Introdução: Disfunções temporomandibulares (DTMs) são um termo genérico para uma série de sinais e sintomas clínicos que envolvem os músculos mastigatórios, a articulação temporomandibular e estruturas associadas. O tratamento de pacientes com DTM deverá envolver uma equipe multidisciplinar e para que haja uma intervenção eficaz no tratamento da disfunção é necessário que os profissionais envolvidos atuem em conjunto e tenham pleno conhecimento das funções estomatognáticas. Objetivo: o objetivo deste artigo é revisar a literatura sobre as formas terapêuticas das disfunções temporomandibulares e sua eficácia. Metodologia: Trata-se de um estudo sobre o panorama atual das terapêuticas utilizadas para o tratamento de disfunções temporomandibulares. Para compor o presente trabalho foi consultado o banco de dados da PubMed utilizando as palavras-chave “temporomandibular disorder” e “therapy” associados ao operador booleano AND. Os critérios de inclusão foram os artigos publicados, limitando-se ao período de 2020 a 2024 no idioma inglês. A busca computou um total de 545 artigos, dos quais foram excluídos os artigos que desviavam do tema proposto, artigos que abordavam técnicas com pouco embasamento científico e os artigos que não estavam disponíveis por completo. Resultados: os achados na literatura corroboram com a escolha em primeiro plano de um tratamento conservador, reversível e não invasivo. Dentre as opções destacam-se orientações de autocuidado, confecção de placa oclusal, terapias manuais, exercícios musculares, biofeedback e manejo farmacológico em casos de sintomas somáticos. A toxina botulínica tem sido sugerida para tratamento em casos de DTMs musculares, no entanto, com baixa evidência científica quanto aos efeitos adversos. Técnicas cirúrgicas são indicadas em casos de não resolução com terapias conservadoras. Conclusões: Apesar da grande diversidade nos protocolos, o tratamento conservador demonstra resolução do problema na maioria dos casos de DTMs e aqueles tratamentos que combinam várias técnicas evidenciam melhores resultados do que tratamentos isolados.
ATENÇÃO PRIMÁRIA E INFORMAÇÃO EM SAÚDE: DESEMPENHO E FINANCIAMENTO NO MUNICÍPIO DE NATAL/RN
Authors: Araújo Isabelle Maria Mendes de , Silva Gabriela Pires da , Silva Gislany Stefane Felício da , Silva Sidcley dos Santos , Lima Roberval Edson Pinheiro de , Nascimento Dmitri Felix do 
Published: September 2024

Introdução: O país adota, com a criação do Programa Previne Brasil, uma nova forma de financiamento da Atenção Primária à Saúde (APS), com a portaria ministerial 2.979/2019, a qual estabeleceu critérios para alocação de recursos, com foco para o desempenho e produtividade da APS. Tal modelo vem sendo alvo de críticas pelo campo acadêmico da Saúde Coletiva e por gestões municipais, que em diferentes situações demonstram perdas financeiras, sobretudo, devido ao componente de capitação ponderada. Objetivo: Sistematizar o desempenho da Atenção Primária à Saúde do município de Natal, Rio Grande do Norte, com base em indicadores de desempenho do Sistema de Informação em Saúde para a Atenção Básica (SISAB), e o financiamento da APS, com base no Sistema de Informações sobre Orçamentos Públicos em Saúde (SIOPS), entre os anos 2019 a 2022. Metodologia: Trata-se de uma pesquisa descritiva-exploratória, com utilização de dados secundários e sistematização dos sete indicadores de desempenho da APS via SISAB e das despesas com saúde, em especial gastos com a APS via SIOPS, do município de Natal/RN. Resultados: Dos sete indicadores analisados, o município de Natal alcançou a meta em dois indicadores, referente à proporção de gestantes com pelo menos seis consultas pré-natal realizadas (46% em 2022) e com realização de exames para sífilis e HIV (67% em 2022). O município destinou à Atenção Primária, em 2022, apenas 6,33% de todas suas despesas com saúde. Destaca-se, também, que a cobertura da APS no município é de 60%, havendo ainda um vazio assistencial para grande parte da população natalense. Conclusões: A análise de indicadores de saúde, torna-se importante ferramenta para a ação avaliativa do SUS, bem como dá suporte para a tomada de decisão por parte de gestores e equipes de saúde, além de produzir conhecimento crítico para a qualificação da APS.
Characterization and In vitro Release & In vivo Behavior Study of Self-Assembled Nano-Emulsion in XiaoYao Pill for Enhanced Drug Delivery
Authors: Yuan Zhao Fang , QingXia Guan , MeiWei Zhu , LianZhi Wang , FangFang Yang , ZhiPing Yang , ZhongXin Chen , XiaoFang Dai 
Published: September 2024

Background:
Traditional Chinese medicine formulations often contain hydrophobic components
with limited solubility and stability, leading to low oral bioavailability. Self-assembled nanoparticles
(SANs) have shown promise in enhancing oral bioavailability of these components.
However, whether un-decocted Chinese herbal pellets can generate SANs and the impact of SANs
formed by multiple components on pharmacokinetic parameters remains unexplored.

Methods:
In this study, single-factor approach was employed to determine the optimal separation
method of nano-emulsion phase of XiaoYao pill (N-XY). Morphological and particle size analyses
confirmed the nanoscale nature of N-XY. High-performance liquid chromatography (HPLC) fingerprint
analysis was conducted to compare the distribution of active ingredients among three different
phases of XiaoYao pill (XY pill). In vitro release studies were performed to evaluate the release
mechanism of four ingredients from N-XY. Additionally, in vivo pharmacokinetics and tissue distribution
behaviors were investigated in rats.

Results:
N-XY exhibited uniform and stable characteristics as a water-in-oil (O/W) nano-emulsion.
Fingerprint analysis identified 25 characteristic peaks and 8 key ingredients in N-XY, with the highest
peak areas. In vitro release studies showed a sustained release behavior of N-XY. The pharmacokinetics
study showed that the ferulic acid of N-XY had a 1.37-fold higher AUC, 1.44-fold lower
Vd/F, 1.39-fold lower CL/F, and a prolonged t1/2 than A-XY, indicating enhanced bioavailability
due to reduced elimination. Furthermore, the tissue distribution revealed that the levels of paeoniflorin
and ferulic acid from N-XY significantly increased in liver, spleen, lungs, uterus and ovaries, exhibiting
targeting characteristics.

Conclusion:
This study comprehensively explored the formation, characterization, and pharmacokinetics
of nano-emulsion in XY pill, introducing novel perspectives and initiating preliminary research
on potential SANs in un-decocted traditional Chinese medicine formulations. It also emphasized
the importance of enhancing pharmacokinetics of hydrophobic components in Chinese herbal
formulations and laid the foundation for future nano-formulation research for XY pill.
Investigation of Dual-Loaded Doxorubicin and Sorafenib Liposomes Co-Modified with Glycyrrhetinic Acid and Cell-Penetrating Peptide TAT
Authors: Su Houlin , Tu Zhiqiang , Jing Lin , Huang Yanling , Liu Xu , Yuan Mingqing 
Published: September 2024

Background:
Combining Doxorubicin (DOX) with sorafenib (SF) is a promising strategy
for treating Hepatocellular Carcinoma (HCC). However, strict dosage control is required for both
drugs, and there is a lack of target selectivity.

Objective:
This study aims to develop a novel nano-drug delivery system for the combined use of
DOX and SF, aiming to reduce their respective dosages, enhance therapeutic efficacy, and improve
target selectivity.

Methods:
DOX/SF co-loaded liposomes (LPs) were prepared using the thin-film hydration method.
The liposomes were modified with 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine (DSPE)-
polyethylene glycol (PEG2000), DSPE-PEG1000-cell penetrating peptide TAT, and Glycyrrhetinic
Acid (GA). The basic properties of the liposomes were characterized. CCK-8 cell viability assays
were conducted using HepG2, MHCC97-H, and PLC cell models, and apoptosis experiments were
performed using HepG2 cells to determine if this delivery system could reduce the respective dosages
of DOX and SF and enhance HCC cytotoxicity. Liposome uptake experiments were performed
using HepG2 cells to validate the target selectivity of this delivery system.

Results:
A GA/TAT-DOX/SF-LP liposomal nano drug delivery system was successfully constructed,
with a particle size of 150 nm, a zeta potential of -7.9 mV, a DOX encapsulation efficiency of
92%, and an SF encapsulation efficiency of 88.7%. Cellular experiments demonstrated that this delivery
system reduced the required dosages of DOX and SF, exhibited stronger cytotoxicity against
liver cancer cells, and showed better target selectivity.

Conclusion:
A simple and referenceable liposomal nano drug delivery system has been developed
for the combined application of DOX and SF in hepatocellular carcinoma treatment.
Mechanisms Underlying the Protective Effects of Obeticholic Acid-Activated FXR in Valproic Acid-Induced Hepatotoxicity via Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulations
Authors: Chen Ya'nan , Zhou Jingkai , Xu Shansen , Wang Lei 
Published: September 2024

Background:
Valproic acid (VPA)-induced hepatotoxicity is among the most common
and severe adverse drug reactions, limiting its clinical application. Recent studies have suggested
that activating the farnesoid X receptor (FXR) could be a promising therapeutic approach to alleviate
VPA-induced hepatotoxicity; however, related research remains limited.

Objective:
This study aims to comprehensively investigate the mechanisms underlying FXR activation
by obeticholic acid (OCA) for the treatment of VPA-induced hepatotoxicity.

Methods:
Network pharmacology was performed to identify potential targets and pathways underlying
the amelioration of VPA-induced hepatotoxicity by OCA. The identified pathways were validated
through GEO data analysis, and the affinities between OCA and potential key targets were
predicted using molecular docking as well as molecular dynamics simulations.

Results:
A total of 462 targets associated with VPA-induced hepatotoxicity and 288 targets of
OCA were identified, with 81 shared targets. KEGG pathway and GO enrichment analysis indicated
that the effect of OCA on VPA-induced hepatotoxicity primarily involved lipid metabolism, as
well as oxidative stress and inflammation. The results from GEO data analysis, molecular docking,
and molecular dynamics simulations revealed a close association between bile secretion, the
PPAR signaling pathway, and the treatment of VPA-induced hepatotoxicity by OCA.

Conclusion:
Our findings suggest that OCA exhibits potential therapeutic efficacy against VPAinduced
hepatotoxicity through multiple targets and pathways, thereby highlighting the therapeutic
potential of FXR as a target for treating VPA-induced hepatotoxicity.
Knowledge and awareness related to Anemia and its treatment; among the Non-Medico Population in the PCMC Region: A Cross-Sectional Survey Study
Authors: Shweta Gupta  , Joshi Mrudula Vinayak  , Shipra Agrahari  , Joshi Vinayak Nilkanth  
Published: September 2024

Background: Anemia, a significant public health concern, particularly among the young adult population aged 18-25 years, is a condition characterized by low hemoglobin levels and reduced red blood cells. Objectives: A cross-sectional survey study aimed to assess the knowledge and awareness regarding anemia and its treatment in non-medico population. Material & Methods: Data from ACS college of PCMC region were obtained by conducting a survey with 307 respondents from the target age group. The survey instrument consisted of validated closed-ended questionnaire designed to evaluate respondents’ knowledge and practices concerning anemia. Results: The survey revealed a generally high level of awareness about anemia as a health issue caused by low iron levels and reduced red blood cell (RBC) counts. Most respondents (83.1%) identified the complete blood count (CBC) as the primary diagnostic test for anemia and recognized iron supplementation (86.6%) and blood transfusions (89.6%) as treatment options. However, gaps in knowledge were identified. The contributing factors, such as worm infestations (37.1%), heavy menstruation (78.5%), and dietary deficiencies (14%), are not widely understood. The survey also highlighted societal biases, with 68.4% perceiving anemic adolescent girls as physically feeble. Regular hemoglobin monitoring and deworming medication intake practices were limited. Conclusion: Anemia awareness was relatively high among the studied population, targeted educational efforts could enhance the understanding of its multifactorial causes, symptoms and treatment. Identified knowledge gaps like misconceptions and biases can lead to improved anemia prevention. Regular hemoglobin monitoring and increasing access to deworming medication could be valuable interventions.
Prevalence and consumption of Millets in various districts of Himachal Pradesh - A Survey Study
Authors: Swati Sharma  , Soni Kapil  , Shalini Thakur  
Published: September 2024

Millets are a group of small seeded grains that are widely grown around the world as cereal crops and used both for human food and fodder. Millets are an important crop of semi-arid area like Asia and especially of India. They are favoured due to its productivity and short growing season under varying weather conditions. In Ayurveda Millets are classified under Ksudra Dhanya. The UN general assembly has declared Year 2023 as the International Year of Millets because it is an ideal solution for countries to increase self-sufficiency and reduce reliance on imported cereal grains. This is an opportunity to raise awareness of and direct policy attention to nutritional and health benefits of Millets. The present study is planned to assess the ground reality of mass awareness about cultivation, consumption of Millets in Himachal Pradesh. About 500 participants from different districts of Himachal Pradesh were selected randomly for survey study and data collected was analyzed. The results of study reflect that population of Himachal Pradesh is fairly aware about Millet’s cultivation and consumption. Though lot of policies to promote cultivation and commercialization of Millet crops are in pipeline by Government of Himachal Pradesh, yet a concerted effort is still required to achieve the desired goal.
Intention to Seek Mental Health Services During the 2022 Shanghai COVID-19 City-Wide Lockdown: Web-Based Cross-Sectional Study
Authors: Luo Lingzi , Li Gen , Tang Weiming , Wu Dan , Hall Brian 
Published: September 2024

Background
The implementation of COVID-19 lockdown measures had immediate and delayed psychological effects. From March 27, 2022, to June 1, 2022, the Shanghai government enforced a city-wide lockdown that affected 25 million residents. During this period, mental health services were predominantly provided through digital platforms. However, limited knowledge exists regarding the general population’s intention to use mental health services during this time.

Objective
This study aimed to assess the intention of Shanghai residents to use mental health services during the 2022 Shanghai lockdown and identify factors associated with the intention to use mobile mental health services.

Methods
An online survey was distributed from April 29 to June 1, 2022, using a purposive sampling approach across 16 districts in Shanghai. Eligible participants were adults over 18 years of age who were physically present in Shanghai during the lockdown. Multivariable logistic regression was used to estimate the associations between demographic factors, lockdown-related stressors and experiences, physical and mental health status, and study outcomes–mobile mental health service use intention (mobile applications and WeChat Mini Programs [Tencent Holdings Limited]).

Results
The analytical sample comprised 3230 respondents, among whom 29.7% (weighted percentage; n=1030) screened positive for depression or anxiety based on the 9-item Patient Health Questionnaire or the 7-item Generalized Anxiety Disorder Scale. Less than one-fourth of the respondents (24.4%, n=914) expressed an intention to use any form of mental health services, with mobile mental health service being the most considered option (19.3%, n=728). Only 10.9% (n=440) used digital mental health services during the lockdown. Factors associated with increased odds of mobile mental health service use intention included being female, being employed, being a permanent resident, experiencing COVID-19–related stressors (such as loss of income, food insecurity, and potentially traumatic experiences), and having social and financial support. Individuals with moderate or severe anxiety, as well as those with comorbid anxiety and depression, demonstrated a higher intention to use mobile mental health services. However, individuals with depression alone did not exhibit a significantly higher intention compared with those without common mental disorders.

Conclusions
Despite a high prevalence of common mental disorders among Shanghai residents, less than one-fourth of the study respondents expressed an intention to use any form of mental health services during the lockdown. Mobile apps or WeChat Mini Programs were the most considered mental health service formats. The study provided insights for developing more person-centered mobile mental health services to meet the diverse needs of different populations.
National Sovereignty and Mining Conflicts in Peru
Authors: Mamani-Flores Adderly , Quispe David Eleazar Barra , Atencio-Mendoza Claudia María Ricardina , Mamani-Zapana William Harold , Paredes-Calatayud Edith Fernanda , Barra-Quispe Tania Laura 
Published: September 2024

Objetive: Understand the theoretical definition of the role of the State and the exercise of its sovereignty in relation to mining concessions in Peru.

Theoretical framework: The notion of State and sovereignty has a deep meaning in the context of the use and exploitation of resources, as well as in the guarantee of well-being for the population within its territory. This concept, originated in the modern era, is related to various socio-cultural, economic and political events. It is made up of elements such as territory (resource), people (population), power (government) and sovereignty (rights), the latter understood as the authority that the people transfer to a government.

Method: Mixed, descriptive and non-experimental method, based on bibliographic analysis and statistical interpretation provided by state institutions, using the SPSS package

Results and Discussion: The results show that the Peruvian State is the entity responsible for regulating and controlling the territory and society; Mining concessions in Peru, being areas granted for the exploration and exploitation of mineral resources and being subject to collective rights, have generated controversies due to their environmental impacts, the quality of life and the participation rights of the social actors involved in these territories.

Research Implications:The internal recognition of a delimited territory and the external distinction of other states is not exclusive to the nation-state, but also an expression of the legal-political order of the peoples that make up the State, thus maintaining a duality in the definition of power. at the local (traditional) level. This analysis is complex since sovereignty allows the State to manage its resources directly.
The Impact of Covid-19 on Religious Tourism: an Approach Through Institutional Logics in Aparecida do Norte – SP
Authors: Oliveira Paulo Roberto Lucas de , Telles Renato , Bernardes Junior Roberto , Santos Peron Avelino , Martins Cristiane Ferreira de Souza 
Published: September 2024

Objective: The objective of this study is to investigate the impact of the COVID-19 pandemic on religious tourism in Aparecida do Norte, aiming to understand the challenges and opportunities generated by the crisis and propose strategies for the sector's recovery and adaptation.

Theoretical Framework: The theory of institutional logics is highlighted, providing a solid foundation for understanding the social and institutional dynamics that permeate religious tourism.

Method: The methodology adopted for this research includes a qualitative approach, comprising a local technical visit, semi-structured interviews with key actors, and document analysis. Data collection was carried out through direct observation, interviews, and the gathering of official documents.

Results and Discussion: The results revealed the existence of conflicting institutional logics among the main agents involved in religious tourism in Aparecida do Norte. In the discussion section, these results are contextualized in light of the theory of institutional logics, highlighting the need for institutional reconfiguration to ensure the sector's sustainability and resilience.

Research Implications: The practical and theoretical implications of this research are discussed, providing insights on how the results can be applied to revitalize the local economy, strengthen institutional articulation, and promote sustainable tourism in Aparecida do Norte. These implications encompass social, economic, and management areas.

Originality/Value: This study contributes to the literature by using the theory of institutional logics to analyze the impact of the pandemic on religious tourism. The relevance and value of this research are evidenced by offering a theoretical proposition that supports the construction of strategies aimed at the sustainability of the local tourism ecosystem in the post-pandemic context.