bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Pharmacist-Led Interventions on (Non)Motor Symptoms, Medication-Related Problems, and Quality of Life in Parkinson Disease Patients: A Pilot Study
Authors: Stuijt Clementine , Karapinar-Çarkit Fatma , van den Bemt Bart , van Laar Teus 
Published: January 2018

Introduction
Patients with Parkinson disease (PD) use multiple drugs. This pill burden with consequent poor adherence may cause worsening of motor symptoms and drug-related problems. Therefore, a multifaceted pharmacist-led intervention program was designed to improve adherence, motor-functioning, and quality of life (QoL) in PD patients.

Methods
This prospective pilot study was performed in an outpatient PD clinic, where usual care was compared with stepwise introduction of 3 interventions: unit dose packaging (UDP), Parkinson KinetiGraph (PKG), and pharmacist-led medication review (MR).The study analyzed endpoints at 6 weeks (stage 1, usual care), 10 weeks (stage 2, UDP), 14 weeks (stage 3, UDP + PKG), and 26 weeks (UDP + PKG + MR) on motor symptoms, medication adherence, and QoL.

Results
Medication adherence improved significantly after the combined UDP, PKG, and MR intervention in nonadherent patients. On time significantly increased from 56% (±30) at stage 1, to 64% (±25) at stage 3, and to 68% (±27) at stage 4, which correlated with an increase of 1.4 and 2.2 hours in stage 3 and 4, respectively. Quality of life only improved significantly after MR (Parkinson's Disease Questionnaire with 8 domains, 21.0 ± 3.5 in stage 3 vs 19.5 ± 5.3 in stage 4, P = 0.01).

Conclusions
Our data did not support the added value of UDP alone or in combination with PKG. Only the combined intervention of UDP, PKG, and MR showed significant improvements in medication adherence, on time, and QoL. This supports the effectiveness of MR by a clinical pharmacist for PD patients in an outpatient setting. Therefore, this small scale study should be followed by larger-scale trials on this topic.
Carbamazepine Treatment of Hyperactivity and Intrusiveness in Dementia
Authors: Stewart Jonathan T. 
Published: January 2018

Abstract
Behavioral problems are seen in most patients with dementia and are often poorly characterized in the literature. We present a 70-year-old man with advanced Alzheimer disease and problematic disinhibited behaviors, including intrusiveness and Witzelsucht (disinhibited humor). These symptoms responded robustly to carbamazepine. Carbamazepine may be a useful adjunct in managing problematic behaviors in dementia, especially when those problems can be framed as behavioral disinhibition.
Electrophysiology of Cranial Nerve Testing: Spinal Accessory and Hypoglossal Nerves
Authors: Stino Amro M. , Smith Benn E. 
Published: January 2018

Summary:
Multiple techniques have been developed for the electrodiagnostic evaluation of cranial nerves XI and XII. Each of these carries both benefits and limitations, with more techniques and data being available in the literature for spinal accessory than hypoglossal nerve evaluation. Spinal accessory and hypoglossal neuropathy are relatively uncommon cranial mononeuropathies that may be evaluated in the outpatient electrodiagnostic laboratory setting. A review of available literature using PubMed was conducted regarding electrodiagnostic technique in the evaluation of spinal accessory and hypoglossal nerves searching for both routine nerve conduction studies and repetitive nerve conduction studies. The review provided herein provides a resource by which clinical neurophysiologists may develop and implement clinical and research protocols for the evaluation of both of these lower cranial nerves in the outpatient setting.
Electrophysiology of Cranial Nerve Testing: Trigeminal and Facial Nerves
Authors: Muzyka Iryna M. , Estephan Bachir 
Published: January 2018

Summary:
The clinical examination of the trigeminal and facial nerves provides significant diagnostic value, especially in the localization of lesions in disorders affecting the central and/or peripheral nervous system. The electrodiagnostic evaluation of these nerves and their pathways adds further accuracy and reliability to the diagnostic investigation and the localization process, especially when different testing methods are combined based on the clinical presentation and the electrophysiological findings. The diagnostic uniqueness of the trigeminal and facial nerves is their connectivity and their coparticipation in reflexes commonly used in clinical practice, namely the blink and corneal reflexes. The other reflexes used in the diagnostic process and lesion localization are very nerve specific and add more diagnostic yield to the workup of certain disorders of the nervous system. This article provides a review of commonly used electrodiagnostic studies and techniques in the evaluation and lesion localization of cranial nerves V and VII.
The genome of the water striderGerris buenoireveals expansions of gene repertoires associated with adaptations to life on the water
Authors: Armisén David , Rajakumar Rajendhran , Friedrich Markus , Benoit Joshua B , Robertson Hugh M. , Panfilio Kristen A. , Ahn Seung-Joon , Poelchau Monica F. , Chao Hsu , Dinh Huyen , Doddapaneni HarshaVardhan , Dugan Shannon , Gibbs Richard A. , Hughes Daniel S.T. , Han Yi , Lee Sandra L. , Murali Shwetha C. , Muzny Donna M. , Qu Jiaxin , Worley Kim C. , Munoz-Torres Monica , Abouheif Ehab , Bonneton François , Chen Travis , Chiang Li-Mei , Childers Christopher P. , Cridge Andrew Graham , Crumière Antonin Jean Johan , Decaras Amelie , Didion Elise M. , Duncan Elizabeth , Elpidina Elena N. , Favé Marie-Julie , Finet Cédric , Jacobs Chris G.C. , Jarvela Alys , Jennings Emily J. , Jones Jeffery W. , Lesoway Maryna P. , Lovegrove Mackenzie , Martynov Alexander , Oppert Brenda , Lillico-Ouachour Angelica , Rajakumar Arjuna , Refki Peter Nagui , Rosendale Andrew J. , Santos Maria Emilia , Toubiana William , van der Zee Maurijn , Vargas Jentzsch Iris M. , Lowman Aidamalia Vargas , Viala Severine , Richards Stephen , Khila Abderrahman 
Published: January 2018

AbstractThe semi-aquatic bugs conquered water surfaces worldwide and occupy ponds, streams, lakes, mangroves, and even open oceans. As such, they inspired a range of scientific studies from ecology and evolution to developmental genetics and hydrodynamics of fluid locomotion. However, the lack of a representative water strider genome hinders thorough investigations of the mechanisms underlying the processes of adaptation and diversification in this group. Here we report the sequencing and manual annotation of theGerris buenoi (G. buenoi)genome, the first water strider genome to be sequenced so far.G. buenoigenome is about 1 000Mb and the sequencing effort recovered 20 949 predicted protein-coding genes. Manual annotation uncovered a number of local (tandem and proximal) gene duplications and expansions of gene families known for their importance in a variety of processes associated with morphological and physiological adaptations to water surface lifestyle. These expansions affect key processes such as growth, vision, desiccation resistance, detoxification, olfaction and epigenetic components. Strikingly, theG. buenoigenome contains three Insulin Receptors, a unique case among metazoans, suggesting key changes in the rewiring and function of the insulin pathway. Other genomic changes include wavelength sensitivity shifts in opsin proteins likely in association with the requirements of vision in water habitats. Our findings suggest that local gene duplications might have had an important role during the evolution of water striders. These findings along with theG. buenoigenome open exciting research opportunities to understand adaptation and genome evolution of this unique hemimetabolous insect.
Time-restricted foraging under natural light/dark condition shifts the molecular clock in the honey bee,Apis mellifera
Authors: Jain Rikesh , Brockmann Axel 
Published: January 2018

AbstractHoney bees have a remarkable sense of time and individual honey bee foragers are capable to adjust their foraging activity with respect to the time of food availability. Although, there is plenty of experimental evidence that foraging behavior is guided by the circadian clock, nothing is known about the underlying cellular and molecular mechanisms. Here we present a first study exploring whether the time-restricted foraging under natural light-dark condition affects the molecular clock in honey bees. In an enclosed flight chamber (12m × 4m × 4m), food was presented either for 2 hours in the morning or 2 hours in the afternoon for several consecutive days and daily cycling of the two major clock genes,cryptochrome2 (cry2)andperiod (per), were analyzed in three different tissues involved in feeding-related behaviors: brain, antennae and subesophageal ganglion (SEG). We found that morning and afternoon trained foragers showed significant phase-differences in the cycling of both clock genes in all three tissues. Furthermore, the phase-differences were more pronounced when the feeder was scented with the general plant odor linalool. Our results clearly demonstrate that foraging time functions as a strong circadian Zeitgeber in honey bees. More surprisingly our results suggest that foraging time might have the potential to override the entrainment effect of the light-dark cycle.
Management control systems and corporate social responsibility: perspectives from a Japanese small company
Authors: Hosoda Masahiro 
Published: January 2018

Purpose
Corporate social responsibility (CSR) has become part of daily business for small- and medium-sized enterprises (SMEs) in Japan. The purpose of this study is to explore how management control systems (MCSs) can support the translation of activities into CSR actions using a case study of a SME in Japan.

Design/methodology/approach
The case is based on an interview with a CEO of a SME in Japan. The paper contributes to the discussion on CSR and MCSs and investigates the integration of CSR activities in SMEs in Japan through MCSs.

Findings
The case company’s formal control systems incorporate environmental and social aspects that are reflected in its top-down, stakeholder-centered approach into CSR through a formal CSR policy. An informal control system is evident and reflected in the CEO’s emphasis on creating shared value by implementing CSR. An interactive control system, a type of formal control system, is useful in the interactions between CEOs and employees and in translating the opinions of stakeholders into CSR actions. Formal control systems can be supported by informal control systems in the implementation of CSR activities.

Originality/value
This research contributes to the management accounting literature by showing that formal and informal control systems can support the motivation of employees and the integration of stakeholders’ opinions on the implementation of SMEs CSR activities in Japan. The MCS approach also contributes to SMEs in Japan that seek to address the demographic and economic challenges.
Climate change in Colombia
Authors: Pardo Martínez Clara Inés , Alfonso P. William H. 
Published: January 2018

Purpose
This research analyses and evaluates the trends and perspectives of climate change in Colombia. This study aims to understand the main ideas and concepts of climate change in five regions of the country by analysing attitudes and values, information habits, institutionalism and the social appropriation of science and technology.

Design/methodology/approach
The research study involved a focus group technique. Ten focus groups in five regions of the country, including rural regions, were administered. The selection of cities and municipalities in this study took into account vulnerability scenarios based on the two criteria of temperature and precipitation for the 2011-2040 period.

Findings
The participants of the focus groups believe that climate change began 10 years ago and that human activities have caused climate change. The main effects of climate change are believed to be droughts and floods that have appeared in the past several years and have negatively impacted agricultural activities and the quality of life of the population. Moreover, the participants believe that it is important to design and apply adequate measures to adapt to and mitigate climate change.

Originality/value
This study makes an important contribution to the extant climate change literature by identifying and categorising the main ideas and knowledge on this issue from the perspective of the population in Colombia. In developing countries with high climate change vulnerability, it is especially important to analyse this issue to determine relevant official policy instruments that could promote adequate actions and instruments to prevent, adapt to and mitigate climate change.
US experiences with STEM education reform and implications for Asia
Authors: Fendos Justin 
Published: January 2018

Purpose
The first indication that traditional lecture-style teaching is not very effective was provided by Dr Donald Bligh in the 1980s and 1990s. As empirical evidence about this fact has continued to accumulate, science, technology, engineering, and math (STEM) education in the USA has undergone a significant change in emphasis away from lecture-based approaches in favor of systems emphasizing more interactive learning. The paper aims to discuss this issue.

Design/methodology/approach
A wide range of experimental research has employed the principles of scientific teaching to investigate the efficacy of an ever widening range of pedagogical methods. For STEM education, the most successful of these has been active learning.

Findings
At its core, active learning is a redesign of in-class activities to maximize interactivity and feedback through facilitated problem-solving environments. Although the efficacies of both scientific teaching and active learning have been verified in a wide range of empirical works, the dissemination of these platforms, in general, teaching has been slow, even in the USA.

Research limitations/implications
The first significant impediment has been an overall lack of awareness coupled with general skepticism about alternative learning methods.

Practical implications
This paper first reviews the education literature behind scientific teaching and active learning before reviewing some of the challenges to their implementation on an institutional level.

Social implications
These challenges and known solutions are then applied to the European and East Asian contexts to examine why scientific teaching and active learning remain predominantly an American phenomenon.

Originality/value
For East Asian countries, the authors offer a commentary on how certain aspects of Confucian classroom culture may interact negatively with efforts to install scientific teaching and active learning systems.
Safety assessment of a high-rise dormitory in case of fire
Authors: Rahouti Anass , Datoussaïd Sélim , Descamps Thierry 
Published: January 2018

Purpose
This paper aims to focus on the combination of fire- and agent-based modelling approaches to assess the level of safety of a multi-storeyed building case study.

Design/methodology/approach
For an existing building to be occupied such as the engineering student dormitory of Mons (Belgium), engineers must establish, among the other things, that the building affords a sufficient level of safety during fire incident. This can be verified in accordance with prescriptive- and performance-based methodologies. The performance-based approach consists on using simulation tools such as fire dynamics simulator with evacuation to ensure/verify the level of safety required. In this paper, a model case study was built and then various scenarios have been implemented to answer some safety questions.

Findings
For this building layout, the results demonstrate that combining different egress components (i.e. stairs and outdoor ladders) has a negative impact on the evacuation process than using only the stairs to evacuate the building; phased evacuation strategy will not necessarily lead to faster evacuation; adding fire doors in the stairs and between the floors has a beneficial effect on the evacuation process.

Originality/value
This case study proposes some recommendations about adapted evacuation strategy and investments to improve the safety of high-rise student’s dormitory in case of fire.
Toward a unified view of technology and activity
Authors: Karanasios Stan 
Published: January 2018

PurposeThis theory development paper argues that activity theory, as a theory of practice, can help overcome long-standing challenges in the field of information systems (IS) by better accounting for the material in work and social activity. It also suggests ways in which IS research can inform the development of activity theory. The purpose of this paper is to be forward looking as much as reflective to advance an enlarged understanding of activity theory, and argue for its development in IS studies.Design/methodology/approachThe paper is conceptual and draws upon existing literature and research to propose and cultivate an updated understanding of activity theory as a theoretical lens capable of accounting for social and technical aspects in IS.FindingsThe paper has three aims. First, to cultivate the use of activity theory in IS. It elaborates on the use and contribution of activity theory in IS, charts it’s use over the last 20 years and discusses how it brings together a range of ideas that have been neglected in other social theories. Second, to explore the challenges surrounding the use of activity theory in understanding interaction between actors and technology. Third, to set an agenda for its advancement in IS, to ruminate upon future research concerning the extension of activity theory and develop a “fourth-generation” activity theory.Originality/valueThe paper presents the first attempt to juxtapose activity theory with other theoretical philosophical perspectives; to chart the use of activity theory in IS over the last 20 years; and, to discuss how activity theory brings together a range of ideas that have hitherto been excluded from – or inadequately formulated in – other contemporary social theories.
Internet Village Motoman Project in rural Cambodia: bridging the digital divide
Authors: Luo Margaret Meiling , Chea Sophea 
Published: January 2018

Purpose
Community wireless networking has become a growing trend in both metropolitan and rural areas around the world. However, few studies have sought to understand what motivates people to use community wireless networks and the unintended effects that those technologies have on communities, particularly for rural users. The purpose of this paper is to explore the benefits and usage of an asynchronous wireless internet system in a rural village of Cambodia to examine the issues and challenges in the acceptance of a new technology in a less-developed country.

Design/methodology/approach
By employing qualitative methods of in-depth case analysis, the authors revealed various usage motivations and unintended effects of the system.

Findings
The authors identified five reasons that motivated users to use the system: avowed identity, a means to an end, maintaining personal ties, power and influence, and psychological commitment and ownership. The unintended effects of the system included increased number of interactions among actors and other uses of the system, including internet commerce, telemedicine, and e-government.

Research limitations/implications
This study explores the wireless internet project known as the “Internet Village Motoman Project” that was initiated by a non-governmental organization with funding from private donors, supplemented with matching funds from the Asian Development Bank and the World Bank.

Originality/value
This study contributes to the academic understanding of rural regions of Cambodia and its evidence supports the current theoretical assumptions that user behaviors are not determined only by users’ decisions alone (as proposed by traditional cognitive IS research), but also by users and their social interactions as stated in the four-dimensional social actor framework proposed by Lamb and Kling (2003). The latter provides better explanation of the motivation for internet use in the region. The theoretical contribution of this study is the useful adoption of the actor-network approach in a non-organizational setting. The findings also contribute to the literature on how practical internet engineering can bridge the digital divide. Fulfilling the needs identified in the research and understanding unintended effects of the system will contribute to the successful implementation of new internet projects in other rural areas.
Comparative human development thresholds for absolute and relative pro-poor mobile banking in developing countries
Authors: A. Asongu Simplice , Nwachukwu Jacinta C. 
Published: January 2018

Purpose
The purpose of this paper is to assess the correlations between mobile banking and inclusive development (poverty and inequality) in 93 developing countries for the year 2011.

Design/methodology/approach
Mobile banking entails the following: “mobile phones used to pay bills” and “mobile phones used to receive/send money”, while the modifying policy indicator includes the human development index (HDI). The data are decomposed into seven sub-panels based on two fundamental characteristics: regions (Latin America, Asia and the Pacific, Central and Eastern Europe, and Middle East and North Africa) and income levels (upper middle income, lower middle income and low income).

Findings
The results show that at certain thresholds of the HDI, mobile banking is positively linked to inclusive development. The following specific findings are established. First, the increased use of mobile phones to pay bills is negatively correlated with: poverty in lower-middle-income countries (LMIC), upper-middle-income countries (UMIC) and Latin American (LA) countries, respectively, at HDI thresholds of 0.725, 0.727 and 0.778 and inequality in UMIC and LA with HDI thresholds of, respectively, 0.646 and 0.761. Second, the increased use of mobile phones to send/receive money is negatively correlated with: poverty in LMIC, UMIC and Central and Eastern European (CEE) countries with corresponding HDI thresholds of 0.631, 0.750 and 0.750 and inequality in UMIC, CEE and LA at HDI thresholds of 0.665, 0.736 and 0.726, respectively.

Practical implications
The findings are discussed in the light of current policy challenges in the transition from the UN’s Millennium Development Goals to Sustainable Development Goals.

Originality/value
The authors have exploited the only macroeconomic data on mobile banking currently available.