bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of ADP-ribosylation in regulating DNA interstrand crosslink repair
Authors: Gunn Alasdair R. , Banos-Pinero Benito , Paschke Peggy , Sanchez-Pulido Luis , Ariza Antonio , Day Joseph , Emrich Mehera , Leys David , Ponting Chris P. , Ahel Ivan , Lakin Nicholas D. 
Published: September 2016

ABSTRACT
ADP-ribosylation by ADP-ribosyltransferases (ARTs) has a well-established role in DNA strand break repair by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium to uncover a role for ADP-ribosylation in regulating DNA interstrand crosslink repair and redundancy of this pathway with non-homologous end-joining (NHEJ). In silico searches were used to identify a protein that contains a permutated macrodomain (which we call aprataxin/APLF-and-PNKP-like protein; APL). Structural analysis reveals that this permutated macrodomain retains features associated with ADP-ribose interactions and that APL is capable of binding poly(ADP-ribose) through this macrodomain. APL is enriched in chromatin in response to cisplatin treatment, an agent that induces DNA interstrand crosslinks (ICLs). This is dependent on the macrodomain of APL and the ART Adprt2, indicating a role for ADP-ribosylation in the cellular response to cisplatin. Although adprt2− cells are sensitive to cisplatin, ADP-ribosylation is evident in these cells owing to redundant signalling by the double-strand break (DSB)-responsive ART Adprt1a, promoting NHEJ-mediated repair. These data implicate ADP-ribosylation in DNA ICL repair and identify that NHEJ can function to resolve this form of DNA damage in the absence of Adprt2.
Safety and effectiveness of rivaroxaban versus standard anticoagulation for the treatment of symptomatic deep vein thrombosis in routine clinical practice
Authors: Haas S. , Kreutz R. , Gebel M. , Herold J. , Schneider J. , Weyrauch P. , Beyer-Westendorf J. , Bauersachs R.M. ,   für die XALIA-DE Studiengruppe
Published: September 2016

SummaryIn addition to parenteral anticoagulants and vitamin K antagonists (standard AC), non-vitamin K antagonist oral anticoagulants (NOAC) are increasingly being used for the acute and long-term treatment of deep vein thrombosis (DVT).The international, prospective, non-interventional XALIA study compared the acute and long-term treatment of DVT with rivaroxaban or standard AC under routine clinical practice and confirmed the safety and efficacy of rivaroxaban demonstrated in Phase III studies: annual event rates for major bleeding, VTE and all-cause mortality were 1.2 %, 2.4 % and 0.8 % respectively, compared to 3.4 %, 3.9 %, and 6.2 % with standard AC.The XALIA-DE subgroup analysis examined whether the XALIA results were applicable to Germany. The 586 rivaroxaban patients were younger and fewer had active cancer than the 355 treated with standard AC. As in XALIA, the incidence of major bleeding (1.6 vs. 4.1/100 patient-years [PY]), recurrent VTE (1.9 vs. 4.7/100 PY) and all-cause mortality (1.6 vs. 6.8/100 PY) were lower under rivaroxaban than under standard AC. These rates indicate a favourable benefit-risk profile of rivaroxaban under the conditions of everyday practice.
Open discectomy vs microdiscectomy for lumbar disc herniation - a protocol for a pragmatic comparative effectiveness study
Authors: Sørlie Andreas , Gulati Sasha , Giannadakis Charalampis , Carlsen Sven M. , Salvesen Øyvind , Nygaard Øystein P. , Solberg Tore K. 
Published: September 2016

Introduction: Since the introduction of lumbar microdiscectomy in the 1970’s, many studies have attempted to compare the effectiveness of this method with that of standard open discectomy with conflicting results. This observational study is designed to compare the relative effectiveness of microdiscectomy (MD) with open discectomy (OD) for treating lumbar disc herniation, -within a large cohort, recruited from daily clinical practice. Methods and analysis: This study will include patients registered in the Norwegian Registry for Spine Surgery (NORspine). This clinical registry collects prospective data, including preoperative and postoperative outcome measures as well as individual and demographic parameters. The primary outcome is change in Oswestry disability index between baseline and 12 months after surgery. Secondary outcome measures are improvement of leg pain and changes in health related quality of life measured by the Euro-Qol-5D between baseline and 12 months after surgery, complications to surgery, duration of surgical procedures and length of hospital stay.
Waiting To Give: Stated and Revealed Preferences
Authors: Craig Ashley C. , Garbarino Ellen , Heger Stephanie A. , Slonim Robert 
Published: September 2016

We estimate and compare the effect of increased time costs on consumer satisfaction and behavior. We are able to move beyond the existing literature, which focuses on satisfaction and intention, and estimate the effect of waiting time on return behavior. Further, we do so in a prosocial context and our measure of cost is the length of time a blood donor spends waiting. We find that relying on satisfaction data masks important time cost sensitivities; namely, it is not how the donor feels about the wait time that matters for return behavior, but rather the actual duration of the wait. Consistent with theory we develop, our results indicate that waiting has a significant longer-term social cost: we estimate that a 38% increase (equivalent to one standard deviation) in the average wait would result in a 10% decrease in donations per year. This paper was accepted by Uri Gneezy, behavioral economics.
THE EFFECT OF Sauropus androgynus LEAF EXTRACT ON PERFORMANCE, EGG QUALITY AND CHEMICAL COMPOSITION OF EGGS
Authors: Santoso U. , Fenita Y. 
Published: September 2016

The purpose of this research was to produce the enriched eggs, but low in cholesterol content. Forty eight layer chickens aged 72 weeks (strain Dekalb Warren) were distributed into six treatment groups. One group of laying hens was fed diets without Sauropus androgynusleaf extract (SALE) as the control, and another five groups were fed diet supplemented to 9 g SALE, 18 g SALE, 27 g SALE, 36 g SALE, and 45 g SALE/kg diet, respectively. Completely randomized design was used in the present study.The experimental results showed that SALE supplementation had no effect on egg production, feed intake, feed conversion ratio, egg weight, yolk weight, albumen weight, shell egg, egg index, eggshell thickness, and yolk index (P>0.05), but significantly affected Haugh Unit, albumen index, yolk color, egg odor, egg taste, and yolk color (P<0.05). The protein, fat, calsium, phosphor, kaliumand iron contents of eggs did not change (P>0.05), but the cholesterol content of egg was significantly reduced (P<0.05). In conclusion, the supplementation of SALE did not enhance performance, but it improve egg quality and its chemical composition.
Positive Answer to Berestycki’s Open Problem on the Unit Ball
Authors: Dai Guowei , Yang Bianxia 
Published: September 2016

Abstract
In this paper, we establish a unilateral global bifurcation result from intervals for a class of semilinear problems on the unit ball. By applying the above result, we obtain the spectrum of a class of half-linear problems on the unit ball. Our results partially give a positive answer to the open problem proposed by Berestycki.
Bibliotheken als Dritte Orte
Authors: Büttner Stephan , Freyberg Lisa 
Published: September 2016

Zusammenfassung
Am Fachbereich Informationswissenschaften der Fachhochschule Potsdam fand vom 27. bis 28. Mai 2016 zum zweiten Mal die #VisDom (Visualisierung von Daten und Informationen – Symposium an der FH Potsdam) statt. Während die Veranstaltung sich 2015 ausschließlich mit der visuellen Darstellung, speziell mit dem Einsatz von AR beschäftigte, war 2016 das Themenfeld wesentlich breiter gefasst und stellte des Prinzip der „Smart Libraries“ in den Vordergrund. Der vorliegende Artikel fasst die wesentlichen Diskussionsbeiträge und Inhalte der Tagung zusammen.
„Schmökerabend“ an der Technischen Hochschule Wildau
Authors: Hofmann Daniel , Dreiß Carina 
Published: September 2016

Zusammenfassung
In diesem Artikel möchten wir unseren, seit 2012 jährlich durchgeführten „Schmökerabend“ näher beleuchten.
Dies soll mit Hauptaugenmerk auf die folgenden drei Aspekte geschehen:

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Das Angebot von Programmpunkten und Workshops vor Ort,

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Ziele und Nutzwert dieser und ähnlicher von der TH und Hochschulbibliothek durchgeführten Veranstaltungen,

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der betriebene Arbeitsaufwand und Hilfsmittel (z. B. Projektmanagement Tools), die für Vorbereitung und Organisation solcher Veranstaltungen interessant oder hilfreich sein können.
Unitals in shift planes of odd order
Authors: Trombetti Rocco , Zhou Yue 
Published: September 2016

Abstract
A finite shift plane can be equivalently defined via abelian relative difference sets as well as planar functions. In this paper, we present a generic way to construct unitals in finite shift planes of odd square order. We investigate various geometric and combinatorial properties of these planes, such as the self-duality, the existence of O’Nan configurations, Wilbrink’s conditions, the designs formed by circles and so on. We also show that our unitals are inequivalent to the unitals derived from unitary polarities in the same shift planes. As designs, our unitals are also not isomorphic to the classical unitals (the Hermitian curves).
On the cohomology and their torsion of real toric objects
Authors: Choi Suyoung , Park Hanchul 
Published: September 2016

Abstract
In this paper, we do the following two things:

(i)
We present a formula to compute the rational cohomology ring of a real topological toric manifold, and thus that of a small cover or a real toric manifold, which implies the formula of Suciu and Trevisan. Furthermore, the formula also works for an arbitrary coefficient ring G in which 2 is a unit.

(ii)
We construct infinitely many real toric manifolds and small covers whose integral cohomology rings have a q-torsion for any positive odd integer q.
On the difference between a Vitali–Bernstein selector and a partial Vitali–Bernstein selector
Authors: Kharazishvili Alexander 
Published: September 2016

Abstract
It is shown that the difference between a Vitali–Bernstein
selector and a partial Vitali–Bernstein selector can be of Lebesgue measure
zero and of first Baire category. This result gives an answer to
a question posed by G. Lazou.
Fast and reliable quantification of lignin reactivity via reaction with dimethylamine and formaldehyde (Mannich reaction)
Authors: Wang Miao , Sjöholm Elisabeth , Li Jiebing 
Published: September 2016

Abstract
The influence of pH on the Mannich reaction (amino alkylation in the presence of formaldehyde) has been analyzed by liquid chromatography-mass spectrometry (LC-MS) with vanillin (VA) as a model compound and a purified softwood kraft lignin (SKL) as a substrate. The reaction products of VA were studied at pH 5, 7, and 9 at 60°C for 4 h. The Mannich adduct and side reaction products with methylene bridge were found at both pH 7 and 9, while only di-substituted by-products were observed at pH 5. Nitrogen contents determined from blank runs were substantial at pH 5 and negligible at pH 7. In VA or SKL, the resulting N-contents at pH 7 corresponded to a 76 or 62 mol% of the theory, respectively, i.e. based on the available C5 positions in phenolic guaiacyl units (G-units). In the case of SKL, 31P-NMR analysis confirmed a 77% conversion of all phenolic G-units into their C5 substituted derivatives. The Mannich reaction should be performed on lignin at pH 7 for 1 h to suppress unwanted side reactions, which could be observed by LC-MS under other pH conditions. The reaction is suitable for fast and reliable determination of reactive C5-positions in lignin by multiplication of the N-content of the reaction products with a factor of 1.6.
The formation and transformation of hormones in maternal, placental and fetal compartments: biological implications
Authors: Pasqualini Jorge R. , Chetrite Gérard S. 
Published: September 2016

Abstract
The fetal endocrine system constitutes the earliest system developing in fetal life and operates during all the steps of gestation. Its regulation is in part dependent on the secretion of placental and/or maternal precursors emanating across the feto-maternal interface. Human fetal and placental compartments possess all the enzymatic systems necessary to produce steroid hormones. However, their activities are different and complementary: the fetus is very active in converting acetate into cholesterol, in transforming pregnanes to androstanes, various hydroxylases, sulfotransferases, while all these transformations are absent or very limited in the placenta. This compartment can transform cholesterol to C21-steroids, convert 5-ene to 4-ene steroids, and has a high capacity to aromatize C19 precursors and to hydrolyze sulfates. Steroid hormone receptors are present at an early stage of gestation and are functional for important physiological activities. The production rate of some steroids greatly increases with fetal evolution (e.g. estriol increases 500–1000 times in relation to non-pregnant women). Other hormones, such as glucocorticoids, in particular the stress hormone cortisol, adipokines (e.g. leptin, adiponectin), insulin-like growth factors, are also a key factor for regulating reproduction, metabolism, appetite and may be significant in programming the fetus and its growth. We can hypothesize that the fetal and placental factors controlling hormonal levels in the fetal compartment can be of capital importance in the normal development of extra-uterine life.
Claiming too much, delivering too little: testing some of Hofstede’s generalisations
Authors: McSweeney Brendan , Brown Donna , Iliopoulou Stravroula 
Published: September 2016

AbstractThis paper considers Geert Hofstede’s claim that his national cultural ‘dimension scores’ and related rankings of countries enable effective prediction by examining a causal generalisation he has repeatedly used to illustrate that capability. When tested against cross-sectional and longitudinal empirical data about conflicts in industrial relations, the generalisation is shown not to have predictive power. A second generalisation is then tested, which also fails to demonstrate predictive capability. This paper discusses some characteristics of valid cross-national research in the light of these predictive failures.
Management adaptation of business association services: long-term stability 1783-2012 and ‘change points’ for Irish chambers of commerce
Authors: Bennett Robert J. 
Published: September 2016

AbstractThis paper seeks to fill an important gap in literature on institutional adaptation, using Irish chambers of commerce services to examine how managers of business associations adjust long-term balances in services, and respond to short-term challenges. The paper uses the theoretical expectations from collective action theory, transactions cost economics, the theory of organisational evolution and interactions with state supports to explore how the management strategies of chambers adapted to challenges from the economic and institutional environment. The paper demonstrates durability in the long term over the 200- year history of chambers, by an adaptation of service bundles and resource mixes, with major ‘change points’ being critical to re-balancing services and income sources. Using the example of challenges arising from the ‘change point’ of the Irish economic contraction 2008–2012, the paper shows how short-term adaptation mechanisms operate. Larger chambers generally survived better. Smaller chambers had more challenges, but demonstrate the durability of engaged management by volunteers.
Analysis of Shrinkage Characteristics of Aluminium Silicon Alloy
Authors: Hussainy Syed Ferhathullah , Mohiuddin Mohd. Viquar , Laxminarayana P. , Sundarrajan S. , Krishnaiah A. 
Published: September 2016

AbstractAnalysis of shrinkage characteristics of Aluminium-Silicon alloy was studied theoretically and experimentally. The Aluminium alloys considered in the study are A413 (LM6), A360 (LM9) and A380 (LM24). Extensive literature survey has suggested that cavity filling and solidification process are two most critical aspects to produce high quality casting components. A statistical model of parameters and response to understand the influence of parameters on shrinkage and casting yield studies has been presented. Experiments were conducted in foundry in industrial environment to produce commercially treated aluminium alloy castings in sand mould. Alloy was found to be most significant factor influencing shrinkage. The yield of casting was improved using insulating and exothermic sleeves. Solidification time of exothermic riser was 10 % more than insulated riser. Thus, in order to produce radiographic quality casting a theoretical and experimental method is presented so that number of trials in foundry is reduced which leads to increased reliability and productivity. Study also shows that by using sleeves considerable metal is saved, energy saving during melting, improved quality, reduced cost and increased capacity of plant can be achieved.
Ergebnisstruktur und Ergebnisentwicklung von Genossenschaftsbanken und Sparkassen Vor dem Hintergrund der Finanzmarktkrise
Authors: Hölscher Reinhold , Kalhöfer Christian , Helms Nils 
Published: September 2016

Abstract
There is an ongoing debate about whether a permanent deterioration in the revenue of banks could be the result of the remaining low interest rate or not. Against this background this article wants to examine how the results of cooperative and savings banks have developed during the last years and how the changed regulatory framework affected negative results of the banks.
PAPP-A, IGFBP-4 and IGF-II are secreted by human adipose tissue cultures in a depot-specific manner
Authors: Gude Mette Faurholdt , Hjortebjerg Rikke , Oxvig Claus , Thyø Anne Anker , Magnusson Nils Erik , Bjerre Mette , Pedersen Steen Bønløkke , Frystyk Jan 
Published: September 2016

ObjectiveAdipose tissue secretes pregnancy-associated plasma protein-A (PAPP-A), which may increase local IGF action through cleavage of IGF-binding protein-4 (IGFBP-4). We tested whether this mechanism was operational in human visceral and subcutaneous adipose tissue (i.e. VAT and SAT).DesignExplants of VAT and SAT from 26 obese subjects (hereof 17 women, BMI 39.5 (37.2; 42.8) kg/m2(median (25%; 75% confidence interval) and SAT from eight lean, age-matched women (BMI 23.6 (22.4; 24.9) kg/m2) were incubated with or without GH (100 µg/L) and the media were harvested.MethodsMedia were assessed for concentrations of PAPP-A, intact and PAPP-A-cleaved IGFBP-4, IGF-I and IGF-II, and IGF-I receptor (IGF-IR) activation by bioassay.ResultsIn obese subjects, VAT media contained higher concentrations than SAT of PAPP-A (4.4-fold) and both PAPP-A-generated IGFBP-4 fragments (C-terminal: 3.3-fold, N-terminal: 1.5-fold) (allP < 0.0005). Intact IGFBP-4 levels were similar in SAT and VAT. VAT media contained elevated IGF-II (1.4-fold;P < 0.005), but similar IGF-I concentrations compared with SAT. Still, VAT media contained a 1.8-fold increased ability to stimulate the IGF-IR (P < 0.005). IGF-I protein concentration and IGF-IR activation increased more in VAT media than SAT media following GH stimulation (bothP < 0.05). At baseline, SAT media protein levels from lean and obese women were similar, with the exception of PAPP-A being 1.8-fold elevated in VAT media (P < 0.05). GH induced a similar increase in IGF-I media levels in SAT from obese and lean women.ConclusionHuman adipose tissue cultures secrete enzymatically active PAPP-A, IGFBP-4 and IGF-II in a depot-specific manner, suggesting differential regulation of IGF activity. Further, IGF-II appears to be more prominent than IGF-I. Finally, VAT appears more GH responsive than SAT.
Manifest Intertextuality and Readability in SLA Handbooks
Authors: Parham Fatemeh 
Published: September 2016

It is argued that meaning has no originatory source and is the outcome of relationships between texts, or intertextuality, the manifest type of which is cued by concrete references to the works of others in direct or indirect forms. The present research, then, is an attempt to illustrate how intertextual networks are set up in SLA handbooks; manifest intertextuality is in the next phase mapped onto a diachronic axis to see if there is any meaningful pattern regulating intertextuality in the corpus of the study. The obtained results revealed a far greater reliance on contemporary works which may be justified in the light of the constant development of our knowledge of the field. Intertextuality is then examined in the framework of relevance theory to show the possible connections between the intertextual quality of a text and its readability. Since many SLA handbooks serve as textbooks for graduate students, the results of this study can help with measuring the degree of readability of handbooks and their optimality for given students.
Crescimento pondero-estatural de pacientes de 0 a 16 anos com anemia ferropriva
Authors: Niero Cintia Vieira , Morais Fábio Almeida , Madeira Kristian , Serafim Guilherme Savi , Serafim Anie Savi , Simões Priscyla Waleska 
Published: September 2016

Introdução: A anemia ferropriva figura entre os problemas de saúde mais comuns da infância, sendo um problema de saúde pública, uma vez que atinge em média 30% da população mundial. Objetivos: Avaliar a influência dos níveis de hemoglobina no crescimento pondero-estatural de pacientes com diagnóstico de anemia ferropriva de 0 a 16 anos. Métodos: Estudo observacional transversal, retrospectivo e quantitativo. A população foi composta por pacientes de 0 a 16 anos que realizaram duas ou mais consultas no período de janeiro/2010 a dezembro/2012, com o diagnóstico de anemia, resultando em 55 prontuários. Resultados: A idade mediana da população no momento do diagnóstico foi de 1,50 anos (1,08 – 3,17). O grupo etário que obteve a maior frequência foi de 1 a 2 anos incompletos, totalizando 49,1% (n=27) dos pacientes. A maior parcela dos pacientes fazia profilaxia com ferro, correspondendo a 50,9% (n=28). Quanto à classificação de peso dos pacientes para a idade em relação à hemoglobina, 3,6% (n=2) dos pacientes foram classificados como baixo peso, 76,4% (n=42) como eutróficos, 18,2% (n=10) como sobrepeso e um paciente (1,8%) como peso elevado. Comparando-se a estatura para a idade dos pacientes em relação à hemoglobina, os eutróficos corresponderam a 89,1% (n=49) da amostra. Conclusão: Não houve relação entre déficit pondero-estatural e anemia ferropriva, porém parece haver relação entre a anemia ferropriva e tendência à obesidade.
GESTÃO DE POLÍTICA PúBLICA DE GERAÇÃO DE TRABALHO E RENDA: uma análise do programa nacional de incubadoras de cooperativas populares
Authors: Natividade Elisângela Abreu , Pereira José Roberto , Oliveira Vânia Aparecida Rezende de 
Published: September 2016

Este estudo tem como objetivo identificar e analisar as principais características da forma de gestão empreendida na condução do Programa Nacional de Incubadoras de Cooperativas Populares (Proninc). Considera que as políticas públicas representam o Estado em ação e entende que a forma de administração que assume o Estado influenciará decisivamente nas características de gestão de uma política pública. Utiliza uma abordagem qualitativa de natureza teórico-empírica. A coleta de informações ocorreu por meio de pesquisa bibliográfica, pesquisa documental e realização de entrevistas com atores-chaves do Proninc. Verifica que, ao apresentar características alinhadas com a perspectiva de gestão pública societal, a gestão do Proninc insere-se no campo de uma administração pública que tem a gestão social como um forte pilar. No entanto, a fragilidade institucional manifestada, sobretudo nas dificuldades vividas em relação às fontes instáveis e inseguras de recursos financeiros, limita o pleno exercício dessa construção e compromete a efetividade da política pública estudada.