bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design, Synthesis and in vitro Antimycobacterial Activities of Isatin‐1,2,3‐triazole‐moxifloxacin Hybrids
Authors: Hu Yuan‐Qiang , Xu Zhi , Qiang Min , Lv Zao‐Sheng 
Published: October 2017

A new class of isatin‐1,2,3‐triazole‐moxifloxacin (MXFX) hybrids 5a–j was designed, synthesized, and screened for their in vitro antimycobacterial activities against Mycobacterium tuberculosis H37Rv and MDR‐TB. All the synthesized hybrids (MIC: 0.10–0.78 μg/mL) exhibited excellent activities against MTB H37Rv and MDR‐TB, in spite of none of them were more potent than the parent MXFX (MIC: 0.10 and 0.12 μg/mL). Against MTB H37Rv, the most active 5f (MIC: 0.10 μg/mL) was comparable with MXFX and 4 times more potent than RIF (MIC: 0.39 μg/mL). Against MDR‐TB, all hybrids were more active than RIF (MIC: 32 μg/mL) and INH (MIC: >128 μg/mL). In particular, hybrid 5e (MIC: 0.10 μg/mL) was comparable with MXFX and 256 and >1,024 times more potent than RIF and INH. Both conjugates 5e and 5f warrant further investigations.
Single‐dose bone pharmacokinetics of vancomycin in a porcine implant‐associated osteomyelitis model
Authors: Bue Mats , Hanberg Pelle , Koch Janne , Jensen Louise Kruse , Lundorff Martin , Aalbæk Bent , Jensen Henrik Elvang , Søballe Kjeld , Tøttrup Mikkel 
Published: October 2017

ABSTRACTThe increasing incidence of orthopaedic methicillin‐resistant Staphylococcus aureus (MRSA) infections represents a significant therapeutic challenge. Being effective against MRSA, the role of vancomycin may become more important in the orthopaedic setting in the years to come. Nonetheless, vancomycin bone and soft tissue penetration during infection remains unclear. In eight pigs, implant‐associated osteomyelitis was induced on day 0, using a Staphylococcus aureus strain. Following administration of 1,000 mg of vancomycin on day 5, vancomycin concentrations were obtained with microdialysis for 8 h in the implant bone cavity, in cancellous bone adjacent to the implant cavity, in subcutaneous adipose tissue (SCT) adjacent to the implant cavity, and in healthy cancellous bone and healthy SCT in the contralateral leg. Venous blood samples were also obtained. The extent of infection and inflammation was evaluated by post‐mortem computed tomography scans, C‐reactive protein serum levels and cultures of blood and swabs. In relation to all the implant cavities, bone destruction was found. Ranging from 0.20 to 0.74, tissue penetration, expressed as the ratio of the area under the concentration–time curve from 0 to the last measured value, was incomplete for all compartments except for healthy SCT. The lowest penetration was found in the implant cavity. In conclusion, Staphylococcus aureus implant‐associated osteomyelitis was found to reduce vancomycin bone penetration, especially in the implant cavity. These findings suggest that it may be unsafe to rely solely on vancomycin therapy when treating acute osteomyelitis. Particularly when metaphyseal cavities are present, surgical debridement seems necessary. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1093–1098, 2018.
Using small‐scale measurements to estimate hypolimnetic oxygen depletion in a deep lake
Authors: Schwefel Robert , Steinsberger Thomas , Bouffard Damien , Bryant Lee D. , Müller Beat , Wüest Alfred 
Published: October 2017

AbstractLow oxygen concentrations in lakes and reservoirs are an ongoing environmental concern, particularly in light of increasing anthropogenic activity and climate change. Oxygen depletion processes in lakes are still not completely understood and a variety of models have been proposed based on limited field observations. Here, we present field measurements of oxygen depletion processes in a deep lake, Lake Geneva (Switzerland). The aim of this study was to quantify three basic processes controlling hypolimnetic oxygen depletion and their relative contribution to the total oxygen depletion (TOD) rate. Sediment oxygen uptake (SOU) and the flux of reduced substances were estimated based on oxygen microprofile measurements and sediment core data of reduced substances. Acoustic Doppler current profiler measurements and hydrodynamic modeling were used to ensure that SOU was measured under typical hydrodynamic conditions. Comparison with long‐term monitoring data allowed for an estimate of the relative importance of SOU and water column mineralization (WCM). Results show a decrease in both SOU and WCM down to mid‐depth which could not be explained by changes in hydrodynamic conditions or temperature. Below mid‐depth, TOD increased due to an enhanced sediment area to water volume ratio (α). This vertical pattern of oxygen depletion is driven by (1) lake morphometry paired with increasing α, and (2) decreasing organic matter mineralization in the water column with depth. The findings are explained by a model which separates the oxygen depletion into an exponentially decreasing component, representing the fast‐decaying fraction of the organic matter, and a constant background component.
Detecting phytoplankton diatom fraction based on the spectral shape of satellite‐derived algal light absorption coefficient
Authors: Zheng Guangming , DiGiacomo Paul M. 
Published: October 2017

AbstractKnowledge about phytoplankton composition is important for biological and biogeochemical research as well as for ecological applications (e.g., water quality) in coastal and inland waters. Satellite remote sensing can potentially map the baseline patterns, anomalies, and trends of phytoplankton composition on a synoptic basis. A prominent challenge is the attribution of the total optical signal to phytoplankton amid interference from minerals and humus. Here, we obtained the phytoplankton light absorption coefficient, aph(λ), in the Chesapeake Bay by partitioning satellite‐derived total light absorption coefficient of water using the generalized stacked‐constraints model (GSCM). We show that the red‐to‐blue band ratio of GSCM‐derived aph(670)/aph(440) can be associated with diatom fraction in Chesapeake Bay. Further, the spatial‐temporal patterns shown in the satellite‐derived diatom fraction data agree well with field studies conducted previously around this region, including low diatom dominance in summer, high diatom dominance in the lower bay in winter, diatom‐dominated spring blooms in coastal waters outside of the bay, and increasing seasonal variability of diatom fraction from the upper to the lower bay. We also found that in the middle bay the summer diatom fraction correlates strongly with spring streamflow on an annual basis, which can be explained because sediment deposited by spring freshets is the main source of silicate supply during summer. These results suggest that the satellite‐derived diatom fraction maps can serve as a baseline for detecting phytoplankton composition anomalies, and highlight the effectiveness of using absorption‐based approach to extract phytoplankton composition information for optically complex waters.
Relaxation Dynamics and Strain Persistency of Azobenzene‐Functionalized Polymers and Actuators
Authors: Skandani Amir A. , Chatterjee Sourav , Wang David H. , Tan Loon‐Seng , White Timothy J. , Shankar Meenakshisundaram Ravi , Smith Matthew L. 
Published: October 2017

AbstractThe accumulation of photoinduced deformation in azobenzene functionalized polymers has received a significant amount of attention in recent years. Critically, the induced photomechanical deformation in these systems experiences varying degrees of relaxation. Control over the persistence of photomechanical strains is vital to the broader utility of these materials in shape programmable systems including soft robotics and engineered origami. Furthermore, investigations of relaxation in light responsive polymer systems triggered by UV light are more prominent than those triggered by blue‐green light. In this study, the impact of chain mobility and initially induced photostrain on the relaxation dynamics of azobenzene‐functionalized polyimides after irradiation with blue light is examined. A modeling effort coupling chromophore population dynamics to material strain is carried out to further explore the relationship between material structure, relaxation dynamics, and macroscopic deformation. The implications for controlling strain persistence are highlighted by simulating one example of a photoprimed bistable actuator.
Preparation of Hollow Fiber Membranes by Nonsolvent Induced Phase Separation along with Hydrogen Gas Formation Using a Single Orifice Spinneret
Authors: Zhang Yu , Chen Yingbo , Hu Xiaoyu , Cheng Bowen , Liu Huiqiang 
Published: October 2017

AbstractTraditional nonsolvent induced phase separation (NIPS) process for fabrication of hollow fiber membranes (HFMs) faces challenges, like design and manufacture of spinneret with two concentric orifices to provide parallel and continuous feed of polymer solution and bore fluid at specific rates. These factors limit the use of traditional technique to produce HFMs. Here, a new direct spinning method for fabricating HFMs by feeding a polymer solution, containing a gas producing agent using single orifice spinneret is reported. Polysulfone‐dimethylacetamide solution containing NaBH4 is extruded through a stainless‐steel needle (single orifice spinneret) into HCl aqueous solution (coagulation bath) at specific rates. Effects of polysulfone concentration, temperature, and pH of coagulant bath on structure and performance of the HFMs are investigated. Synergy between hydrogen from NaBH4 hydrolysis and NIPS process benefits fabrication of HFMs with good hollow bore structure and high porous wall. The prepared HFMs show good dye separation.
Effects of Dairy Products Consumption on Body Weight and Body Composition Among Adults: An Updated Meta‐Analysis of 37 Randomized Control Trials
Authors: Geng Tingting , Qi Lu , Huang Tao 
Published: October 2017

ScopeEffects of dairy consumption on body weight and body composition have been inconsistently observed in randomized control trials (RCTs). Our meta‐analysis aims to systematically evaluate the effects of dairy consumption on body weight and body composition among the adults.Methods and resultsWe conducted a comprehensive search of the Cochrane Library, PubMed, and Embase databases of the relevant studies from 1966 to Mar 2017 regarding dairy consumption on body weight and body composition including body fat, lean mass, and waist circumference (WC). The summary results are pooled by using a random‐effects meta‐analysis. Thirty‐seven RCTs with 184 802 participants are included in this meta‐analysis. High dairy intervention increased body weight (0.01, 95% CI: −0.25, 0.26, I2 = 78.3%) and lean mass (0.37, 95% CI: 0.11, 0.62, I2 = 83.4%); decreased body fat (−0.23, 95% CI: −0.48, 0.02, I2 = 78.2%) and WC (−1.37, 95% CI: −2.28, −0.46, I2 = 98.9%) overall. In the subgroup analysis, we found that consumption of dairy products increases body weight (0.36, 95% CI: 0.01, 0.70, I2 = 83.1%) among participants without energy restriction. Dairy consumption decreases body weight (−0.64, 95% CI: −1.05, −0.24, I2 = 60.2%), body fat (−0.56, 95%CI: −0.95, −0.17, I2 = 66.6%), and waist circumference (−2.18, 95%CI: −4.30, −0.06, I2 = 99.0%) among the adults with energy restriction.ConclusionsThis meta‐analysis suggests a beneficial effect of energy‐restricted dairy consumption on body weight and body composition. However, high dairy consumption in the absence of caloric restriction may increase body weight.
Decoy receptor 3 promotes cell adhesion and enhances endometriosis development
Authors: Tsai Hsiao‐Wen , Huang Ming‐Ting , Wang Peng‐Hui , Huang Ben‐Shian , Chen Yi‐Jen , Hsieh Shie‐Liang 
Published: October 2017

AbstractEndometriosis is a multifactorial inflammatory disease with persistent activation of the nuclear factor‐κB (NF‐κB) signalling pathway. Aberrant adhesion of endometrium is the essential step in the progression of endometriosis, but the molecular mechanism of ectopic growth of endometrium is still unclear. Decoy receptor 3 (DcR3)/TNFRSF6B, a pleiotropic immunomodulator regulated by oestrogen, is able to activate focal adhesion kinase to promote cell adhesion. We found that DcR3 is upregulated in human ectopic endometrial cells via activation of the Akt–NF‐κB signalling pathway, and its expression level correlates positively with that of the adhesion molecules intercellular adhesion molecule 1 (ICAM‐1) and homing cell adhesion molecule (HCAM; CD44). In a multivariate regression model, DcR3 expression level was the most significant parameter associated with endometriosis severity. Knockdown of DcR3 not only downregulated the expression of ICAM‐1 and HCAM, but also reduced cell adhesion and migration. In vivo investigation further showed that DcR3 promoted the growth and spread of endometrium, whereas knockdown of DcR3 by lentivirus‐delivered short hairpin RNA inhibited ectopic adhesion of endometrium and abrogated endometriosis progression. These observations are in support of DcR3 playing a critical role in the pathogenesis of endometriosis, and the inhibition of DcR3 expression being a promising approach for the treatment of endometriosis. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
GUB06‐046, a novel secretin/glucagon‐like peptide 1 co‐agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice
Authors: van Witteloostuijn Søren B. , Dalbøge Louise S. , Hansen Gitte , Midtgaard Søren Roi , Jensen Grethe Vestergaard , Jensen Knud J. , Vrang Niels , Jelsing Jacob , Pedersen Søren L. 
Published: October 2017

Bariatric surgery is currently the most effective treatment of obesity, which has spurred an interest in developing pharmaceutical mimetics. It is thought that the marked body weight‐lowering effects of bariatric surgery involve stimulated secretion of appetite‐regulating gut hormones, including glucagon‐like peptide 1. We here report that intestinal expression of secretin is markedly upregulated in a rat model of Roux‐en‐Y gastric bypass, suggesting an additional role of secretin in the beneficial metabolic effects of Roux‐en‐Y gastric bypass. We therefore developed novel secretin‐based peptide co‐agonists and identified a lead compound, GUB06‐046, that exhibited potent agonism of both the secretin receptor and glucagon‐like peptide 1 receptor. Semi‐acute administration of GUB06‐046 to lean mice significantly decreased cumulative food intake and improved glucose tolerance. Chronic administration of GUB06‐046 to diabetic db/db mice for 8 weeks improved glycemic control, as indicated by a 39% decrease in fasting blood glucose and 1.6% reduction of plasma HbA1c levels. Stereological analysis of db/db mice pancreata revealed a 78% increase in beta‐cell mass after GUB06‐046 treatment, with no impact on exocrine pancreas mass or pancreatic duct epithelial mass. The data demonstrate beneficial effects of GUB06‐046 on appetite regulation, glucose homeostasis, and beta‐cell mass in db/db mice, without proliferative effects on the exocrine pancreas and the pancreatic duct epithelium. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.
Event‐triggered MPC design for distributed systems toward global performance
Authors: Mi Xiaoxiao , Zou Yuanyuan , Li Shaoyuan 
Published: October 2017

SummaryThis paper studies the coordination control problem of stabilizing large‐scale dynamically coupled systems via a novel event‐triggered distributed model predictive control (DMPC) approach. In order to achieve global performance, certain constraints relevant to the triggering instant are imposed on the DMPC optimization problem, and triggering mechanisms are designed by taking into account coupling influences. Specifically, the triggering conditions derived from the feasibility and stability analysis are based on the local subsystem state and the information received from its neighbors. Based on these triggering mechanisms, the event‐triggered DMPC algorithm is built, and a dual‐mode strategy is adopted. As a result, the controllers solve the optimization problem and coordinate with each other asynchronously, which reduces the amount of communication and lowers the frequency of controller updates while achieving global performance. The recursive feasibility of the proposed event‐triggered DMPC algorithm is proved, and sufficient parameter conditions about the prediction horizon and the triggering threshold are established. It shows that the system state can be gradually driven into the terminal set under the proposed strategy. Finally, an academic example and a realistic simulation problem to the water level of a 4‐tank system are provided to verify the effectiveness of the proposed algorithm.
Stochastic model predictive control for probabilistically constrained Markovian jump linear systems with additive disturbance
Authors: Lu Jianbo , Xi Yugeng , Li Dewei 
Published: October 2017

SummaryModel predictive control (MPC) for Markovian jump linear systems with probabilistic constraints has received much attention in recent years. However, in existing results, the disturbance is usually assumed with infinite support, which is not considered reasonable in real applications. Thus, by considering random additive disturbance with finite support, this paper is devoted to a systematic approach to stochastic MPC for Markovian jump linear systems with probabilistic constraints. The adopted MPC law is parameterized by a mode‐dependent feedback control law superimposed with a perturbation generated by a dynamic controller. Probabilistic constraints can be guaranteed by confining the augmented system state to a maximal admissible set. Then, the MPC algorithm is given in the form of linearly constrained quadratic programming problems by optimizing the infinite sum of derivation of the stage cost from its steady‐state value. The proposed algorithm is proved to be recursively feasible and to guarantee constraints satisfaction, and the closed‐loop long‐run average cost is not more than that of the unconstrained closed‐loop system with static feedback. Finally, when adopting the optimal feedback gains in the predictive control law, the resulting MPC algorithm has been proved to converge in the mean square sense to the optimal control. A numerical example is given to verify the efficiency of the proposed results.
Cu–Immobilized Mesoporous Silica Nanoparticles [Cu2+@MSNs‐(CO2−)2] as an Efficient Nanocatalyst for One‐Pot Synthesis of Pyrazolopyranopyrimidines in Water
Authors: Nasresfahani Zahra , Kassaee Mohammad Zaman 
Published: October 2017

AbstractAbstract Cu2+@MSNs‐(CO2−)2 has been prepared and characterized by using small angle powder X‐ray diffraction (XRD), Nitrogen adsorption–desorption analysis, Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), Energy dispersive X‐ray (EDX), Thermal analyses (TGA‐DTA) and FT‐IR studies. A facile one‐pot, four‐component condensation reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes, and barbituric acid for synthesis of pyrazolopyranopyrimidines is efficiently catalyzed over Cu2+@MSNs‐(CO2−)2 in water. This catalyst is easily recovered from the reaction mixture and reused several times without any loss in catalytic activity.
A Dimetallic Aminonitrone Nickel(II) Complex: Further Insights into Metal‐Mediated Nucleophilic Activation of Amidoximes
Authors: Bolotin Dmitrii S. , Bikbaeva Zarina M. , Novikov Alexander S. , Suslonov Vitalii V. , Bokach Nadezhda A. 
Published: October 2017

AbstractThe reaction of NiCl2•2H2O with acetamidoxime (MeC(NH2)=NOH) in the presence of PhCN in MeOH gave the cationic dimetallic complex [1]Cl4, bearing bridging O‐coordinated aminonitrone and chelating imidoylamidoxime ligands, derived from amidoxime‐PhCN coupling. The experimental data and theoretical calculations (M06/MDF10(Ni) and 6–31G*(other atoms) indicated that the aminonitrone form of amidoxime was stabilized only as a μ2‐O‐bridging ligand, whereas Noxime‐coordination was preferred rather than O‐coordination for monodentate‐coordinated amidoximes.
Grains in Selectively Grown MoS2 Thin Films
Authors: Kim Hyung‐Jun , Kim Hojoong , Yang Suk , Kwon Jang‐Yeon 
Published: October 2017

AbstractTransition metal dichalcogenides (TMDCs) have recently been studied using various synthesis methods, such as chemical vapor deposition for large‐scale production. Despite the realization of large‐scale production with high material quality, a range of approaches have been made to solve the patterning issue of TMDCs focusing on the application of integrated devices; however, patterning is still under study to accurately represent nanoscale‐sized patterns, as well as the desired positions and shapes. Here, an insulating substrate is treated selectively with O2 plasma, and MoS2 growth is induced in the superhydrophilic area. Selectively well‐grown MoS2 patterns are confirmed by atomic force microscopy and Raman and photoluminescence spectroscopy. In addition, the grain size, according to the growth size, and grain boundary are analyzed by annual dark field transmission electron microscopy (TEM) and spherical aberration‐corrected scanning TEM to confirm the selective growth. An analysis of the device performance and the optical properties reveals an enhancement with increasing grain size. This method presents the path of the growth technique for patterning, as well as the direction that can be applied to devices and integrated circuits.
K‐MING: A mobile proxy handoff control scheme for proximate group‐based geodata sharing
Authors: Huang Chung‐Ming , Mai Chia‐Ming 
Published: October 2017

SummaryThis work adopts a mobile social network in proximity (MSNP)–centric group touring service concept to share geo–points of interest's (POIs') data among mobile users belonging to the same touring group. In a group‐based touring service, a mobile user can create a group in the MSNP that can consist of some clusters in which some members having the 3G/3.5G/4G cellular network service are selected as cluster leaders to enable their Wi‐Fi hot spot functions as mobile proxies. After that, each group member can join one of the clusters by connecting with a cluster leader's Wi‐Fi hot spot. Thereafter, each cluster leader downloads geo‐POIs' data using 3G/3.5G/4G cellular network and then shares the downloaded POIs' data with its cluster members through its Wi‐Fi hot spot. This work proposed a handoff mechanism such that each mobile user can handoff from its currently connected cluster to the other one that belongs to the same MNSP group. The main handoff concern is that each handheld device only allows a limited number of handheld devices to connect with its Wi‐Fi hot spot at the same time. This work proposed a K‐member‐limited MSNP‐based INter Group handoff scheme called K‐MING to tackle the handoff problem. The performance analysis shows that K‐MING for the group touring scenario has better performance for the sharing of geo‐POIs' data downloading in terms of average power consumption and average downloaded data volume from 3G/3.5G/4G cellular network than that of the individual touring scenario.
Tri‐Texts: A Potential Next Step for Paired Texts
Authors: Ciecierski Lisa M. , Bintz William P. 
Published: October 2017

AbstractThis article presents the concept of tri‐texts as a potential next step from paired texts following a collaborative inquiry with fifth‐grade students. Paired texts are two texts intertextually connected, whereas tri‐texts are three texts connected this way. The authors begin the article with a short literature review highlighting some of the benefits of teaching in an intertextual manner. Next, a minilesson demonstrating how tri‐texts might be used in the classroom is presented. Several tri‐texts that may be considered for use in the classroom are also shared. Final thoughts are presented to conclude the article.