bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing environmental and spatial variables associated with the incidental catch of olive ridley (Lepidochelys olivacea) in the Eastern Tropical Pacific purse‐seine fishery
Authors: Montero Jose T. , Martinez‐Rincon Raul O. , Heppell Selina S. , Hall Martin , Ewal Michael 
Published: December 2015

AbstractIn the Eastern Tropical Pacific (ETP), a region of high fishing activity, olive ridley (Lepidochelis olivacea) and other sea turtles are accidentally caught in fishing nets with tuna and other animals. To date, the interaction between fishing activity, ocean conditions and sea turtle incidental catch in the ETP has been described and quantified, but the factors leading to the interaction of olive ridleys and fishing activity are not well understood. This information is essential for the development of future management strategies that avoid bycatch and incidental captures of sea turtles. We used Generalized additive models (GAM) to analyze the relationship between olive ridley incidental catch per unit effort (iCPUE) in the ETP purse‐seine fisheries and environmental conditions, geographic extent and fishing set type (associated with dolphins, floating objects or in free‐swimming tuna schools). Our results suggest that water temperature, set type and geographic location (latitude, longitude and distance to nesting beaches) are the most important predictor variables to describe the probability of a capture event, with the highest iCPUE observed in sets made over floating objects. With the environmental predictors used, sea surface temperatures (SST) of 26–30°C and chlorophyll‐a (chl‐a) concentrations <0.36 mg m−3 were associated with the highest probability of an incidental catch. Temporally, the highest probability of an incidental catch was observed in the second half of the year (June to December). Four regions were observed as high incidental catch hotspots: North and south of the equator between 0–10°N; 0–10°S and from 120 to 140°W; and along the Colombian coast and surrounding regions.
Spatial association between northern fur seal (Callorhinus ursinus) and potential prey distribution during the wintering period in the northern Sea of Japan
Authors: Horimoto Takanori , Mitani Yoko , Sakurai Yasunori 
Published: December 2015

AbstractElucidating the response of marine predators to oceanographic features helps in understanding their foraging strategies and the cause of their spatial overlap and interference with fishery activities. Northern fur seal is a highly pelagic species during the wintering period. In recent years, fur seals have consistently been found distributed near the coast of southwest Hokkaido, Japan. Because interference by fur seals with coastal fishery activities has become a serious concern, an understanding is sought as to why fur seals come ashore in this area. We conducted ship‐based observations and estimated fur seal density. To elucidate the spatial and seasonal association of fur seal distribution and ocean environments, we constructed statistical models to describe how potential prey distribution and oceanographic features influenced the fur seal spatial distribution during the wintering period. Fur seal distribution corresponded markedly to potential prey distribution, and they tended to aggregate along the narrow continental shelf that is the main geographic feature of this area, which is 2000 m deep and approximately 10 km from the coast. Walleye pollock [Gadus chαlcogrαmmα(Theragra chαlcogrαmmα)] and arabesque greenling (Pleurogrammus azonus), which are one of the main prey for fur seals, move to the shallow area to spawn on the continental shelf seasonally, so potential prey abundance could be higher in coastal areas than offshore. Moreover, the absence of a mesopelagic biotic community may be one of the main factors in the coastal distribution of the fur seal.
North by north‐west: climate change and directions of density shifts in birds
Authors: Lehikoinen Aleksi , Virkkala Raimo 
Published: December 2015

AbstractThere is increasing evidence that climate change shifts species distributions towards poles and mountain tops. However, most studies are based on presence–absence data, and either abundance or the observation effort has rarely been measured. In addition, hardly any studies have investigated the direction of shifts and factors affecting them. Here, we show using count data on a 1000 km south–north gradient in Finland, that between 1970–1989 and 2000–2012, 128 bird species shifted their densities, on average, 37 km towards the north north‐east. The species‐specific directions of the shifts in density were significantly explained by migration behaviour and habitat type. Although the temperatures have also moved on average towards the north north‐east (186 km), the species‐specific directions of the shifts in density and temperature did not correlate due to high variation in density shifts. Findings highlight that climate change is unlikely the only driver of the direction of species density shifts, but species‐specific characteristics and human land‐use practices are also influencing the direction. Furthermore, the alarming results show that former climatic conditions in the north‐west corner of Finland have already moved out of the country. This highlights the need for an international approach in research and conservation actions to mitigate the impacts of climate change.
Impact of branched‐chain amino acid supplementation on survival in patients with advanced hepatocellular carcinoma treated with sorafenib: A multicenter retrospective cohort study
Authors: Imanaka Kazuho , Ohkawa Kazuyoshi , Tatsumi Tomohide , Katayama Kazuhiro , Inoue Atsuo , Imai Yasuharu , Oshita Masahide , Iio Sadaharu , Mita Eiji , Fukui Hiroyuki , Yamada Akira , Nakanishi Fumihiko , Inada Masami , Doi Yoshinori , Suzuki Kunio , Kaneko Akira , Marubashi Shigeru , Ito Yuri , Fukui Keisuke , Sakamori Ryotaro , Yakushijin Takayuki , Hiramatsu Naoki , Hayashi Norio , Takehara Tetsuo ,   the Osaka Liver Forum
Published: December 2015

AimThe therapeutic efficacy of branched‐chain amino acid (BCAA) when added to sorafenib has not been fully assessed in patients with advanced hepatocellular carcinoma (HCC). This multicenter study investigated whether BCAA supplementation improves prognosis in patients with advanced HCC who underwent sorafenib treatment.MethodsThis retrospective analysis included 256 patients with advanced HCC treated with sorafenib, including 55 who did and 201 who did not receive BCAA supplementation. Clinical characteristics and outcomes in relation to Child–Pugh classification were compared in the two groups. Statistical analyses of univariate, multivariate and propensity score‐based procedures were used for this study.ResultsAssessment of 216 Child–Pugh A patients showed that median overall survival was significantly longer in patients with BCAA supplementation than in those without it (440 vs 299 days, P = 0.023). Multivariate analysis showed that BCAA supplementation (P = 0.023), low α‐fetoprotein (<100 ng/mL) (P < 0.001), less progressive Barcelona Clinic Liver Cancer stage (A and B) (P = 0.007) and male sex (P = 0.018) were significant independent contributors to better overall survival. The significantly longer overall survival by BCAA supplementation was verified in the analysis using the propensity score in combination with the inverse probability of treatment weighted adjustment (P = 0.026). Assessment of the 40 Child–Pugh B patients showed no significant differences in overall survival between patients with and without BCAA supplementation.ConclusionBCAA supplementation may be a valuable adjunctive therapy for improving prognosis in sorafenib‐treated Child–Pugh A patients with advanced HCC.
Ductal carcinoma in situ – update on risk assessment and management
Authors: Pang Jia‐Min B , Gorringe Kylie L , Fox Stephen B 
Published: December 2015

Ductal carcinoma in situ (DCIS) accounts for ~20–25% of breast cancers. While DCIS is not life‐threatening, it may progress to invasive carcinoma over time, and treatment intended to prevent invasive progression may itself cause significant morbidity. Accurate risk assessment is therefore necessary to avoid over‐ or undertreatment of an individual patient. In this review we will outline the evidence for current management of DCIS, discuss approaches to DCIS risk assessment and challenges facing identification of novel DCIS biomarkers.
E‐cadherin immunohistochemistry in breast pathology: uses and pitfalls
Authors: Canas‐Marques Rita , Schnitt Stuart J 
Published: December 2015

E‐cadherin immunohistochemistry is used commonly in surgical pathology practice to help distinguish lobular carcinoma in situ from ductal carcinoma in situ and invasive lobular carcinoma from invasive ductal carcinoma in histologically problematic or indeterminate cases. However, the interpretation of E‐cadherin immunostains is not always straightforward. Failure to recognize the pitfalls and limitations of E‐cadherin immunostains can lead to an erroneous diagnosis which may result in inappropriate patient management, particularly for patients with in‐situ lesions. In this paper we review the uses and, particularly, the pitfalls in the interpretation of E‐cadherin immunostains in distinguishing lobular from ductal lesions of the breast.
Overcoming super‐knock down resistance (super‐kdr) mediated resistance: multi‐halogenated benzyl pyrethroids are more toxic to super‐kdr than kdr house flies
Authors: Sun H. , Tong K. P. , Kasai S. , Scott J. G. 
Published: December 2015

AbstractTarget site insensitivity because of mutations in the voltage‐sensitive sodium channel gene (Vssc) is a major mechanism of resistance to pyrethroid insecticides in the house fly, Musca domestica. There are three known Vssc alleles that confer resistance to pyrethroids in the house fly: knock down resistance (kdr; L1014F), super‐kdr (M918T + L1014F) and kdr‐his (L1014H), but there has been no side‐by‐side comparison of the resistance levels that they confer. We compared the levels of resistance conferred by the three Vssc alleles in congenic strains to 19 structurally diverse pyrethroids, and compared the full‐length Vssc cDNA sequences from each strain. Generally, the levels of resistance conferred were kdr‐his < kdr < super‐kdr. However, there was significant variation in this pattern, especially for super‐kdr, for which both high and low resistance ratios were observed for several pyrethroids. We also examined the levels of resistance in heterozygotes. Resistance in each of the hybrids was generally inherited as an incompletely recessive trait, except for the kdr‐his/kdr hybrids, which showed incompletely to completely dominant resistance (ie had resistance levels comparable to kdr homozygotes). The importance of these results to understanding the frequencies of these resistance alleles in natural populations, the evolution of insecticide resistance and resistance management strategies are discussed.
Beliefs about antidepressant medication and associated adherence among older Chinese patients with major depression: A cross‐sectional survey
Authors: Lu Yang , Arthur David , Hu Lili , Cheng Gen , An Fengrong , Li Zheng 
Published: December 2015

AbstractAntidepressant non‐adherence among people with depressive disorder is a major, ongoing public health issue, yet few studies have focused on older adults and their medication adherence. Although treatment adherence is determined by multiple factors, one of the important and modifiable predictors are patients’ attitudes and beliefs about medication. We explored a sample of 135 older Chinese people with major depression, and the relationship between beliefs about antidepressants and medication adherence. Sociodemographic and illness variables were also examined. In all, high antidepressant adherence was reported in 37.8%, moderate adherence in 39.2%, and low adherence in 23%. Ordinal regression analysis showed perceived necessity (P < 0.01) and concern (P < 0.01) about antidepressants were significant influencing factors. Other variables with a positive association with higher adherence were lower average income (P < 0.05), fewer number of prior episodes of depression (P < 0.01), and comorbid anxiety (P < 0.05). The present study highlights low adherence in a sample of older depressed Chinese people, and highlights how beliefs about medication affect adherence. Therefore, more attention should be focused on non‐adherence in older patients, and there is a need to establish accessible and systematic education programmes to correct misconceptions to improve their adherence.
Revitalising young workers' union participation: a comparative analysis of two organisations in Quebec (Canada)
Authors: Dufour‐Poirier Mélanie , Laroche Mélanie 
Published: December 2015

AbstractThis paper examines how two trade union organisations in Quebec (Canada) manage to integrate issues of concern to young members (30 years old and under) and spur changes in their agenda, structures and practices. Between 2009 and 2014, 25 interviews were conducted in these two organisations, while 41 focus group discussions were held with more than 430 members. We contend that improving young members' feeling of belonging to the union, enhancing internal network density and implementing more participatory forms of democracy are key elements when it comes to increasing their participation. Our findings reveal that unions must dare to integrate young members, without seeking to mould them to fit with the values and practices they deem to be outdated. It means not only training young members to carry the necessary message to their peers but also allowing them to challenge the strategic orientations suggested therein.
Antecedents of concession bargaining in the Great Recession: evidence from Ireland
Authors: Roche William K. , Teague Paul 
Published: December 2015

AbstractConcession or ‘give back’ bargaining involves firms seeking changes in pay and conditions of employment from trade unions in return for pledges of enhanced job security and sometimes other forms of reciprocation. Several distinct modes of concession bargaining are distinguishable in the literature, and three modes of concession bargaining have been identified in Ireland during the Great Recession: integrative, distributive and minimal engagement. Deploying qualitatively informed quantitative data on the conduct of collective bargaining during the Great Recession, this article examines a series of antecedent influences on the choices firms make in conducting concession bargaining with unions.
Access to multiple mates increases fecundity but does not affect per‐offspring maternal investment in a marine gastropod
Authors: Collin Rachel , Ochoa Isis 
Published: December 2015

AbstractFemales of many organisms mate more than once and with more than one male, suggesting that polyandry confers some advantage to the female or her offspring. However, variation in maternal investment in response to mate choice and mate number can confound efforts to determine if there are benefits of polyandry. Access to multiple mates could increase maternal investment in offspring via a number of different mechanisms. Few studies have determined if investment is influenced by mate choice and number, and data are particularly lacking for marine invertebrates. This study was designed to determine if maternal investment and offspring size increase with access to increasing numbers of mates in the protandrous intertidal slipper snail Crepidula cf. marginalis. Virgin female slipper limpets were exposed to one, three, or five potential mates and their fecundity, egg size, and hatchling size were measured for multiple clutches. Treatment had a significant effect on fecundity, with fecundity increasing with the number of potential mates. Treatment did not have an effect on the size of eggs or hatchlings, on the variation in egg size or hatchling size within broods, or on the frequency of oviposition. Treatment did alter the variation in average offspring size among females, but not in the way predicted by theory. The main result, that access to multiple mates does not have an effect on per offspring maternal investment, makes C. cf. marginalis an ideal candidate to study the effects of polyandry on offspring fitness without having to take into account confounding effects of variation in maternal investment.
The influence of the starvation–predation trade‐off on the relationship between ambient temperature and body size among endotherms
Authors: McNamara John M. , Higginson Andrew D. , Verhulst Simon 
Published: December 2015

AbstractAimThe tendency for animals at higher latitudes to be larger (Bergmann's rule) is generally explained by recourse to latitudinal effects on ambient temperature and the food supply, but these receive only mixed support and do not explain observations of the inverse to Bergmann's rule. Our aim was to better understand how ecological variables might influence body size and thereby explain this mixed support.LocationWorld‐wide.MethodsPrevious explanations do not allow for the selective pressure exerted by the trade‐off between predation and starvation, which we incorporate in a model of optimal body size and energy storage of a generalized homeotherm. In contrast to existing arguments, we concentrate on survival over winter when the food supply is poor and can be interrupted for short periods.ResultsWe use our model to assess the logical validity of the heat conservation hypothesis and show that it must allow for the roles of both food availability and predation risk. We find that whether the effect of temperature on body size is positive or negative depends on temperature range, predator density, and the likelihood of long interruptions to foraging. Furthermore, changing day length explains differing effects of altitude and latitude on body size, leading to opposite predictions for nocturnal and diurnal endotherms. Food availability and ambient temperature can have counteracting selective pressures on body mass, and can lead to a non‐monotonic relationship between latitude and size, as observed in several studies.Main conclusionsOur work provides a theoretical framework for understanding the relationships between the costs and benefits of large body size and eco‐geographical patterns among endotherms world‐wide.
Performance of magnetic resonance elastography in primary sclerosing cholangitis
Authors: Eaton John E , Dzyubak Bogdan , Venkatesh Sudhakar K , Smyrk Thomas C , Gores Gregory J , Ehman Richard L , LaRusso Nicholas F , Gossard Andrea A , Lazaridis Konstantinos N 
Published: December 2015

AbstractBackground and Aim:Liver stiffness (LS) measured by magnetic resonance elastography (MRE) is emerging as an important biomarker in chronic liver diseases. We examined the diagnostic performance of MRE, factors associated with an increased LS and the prognostic value of LS as measured by MRE among patients with primary sclerosing cholangitis (PSC).Methods:We performed a retrospective review of 266 patients with PSC to examine whether LS was associated with the primary endpoint of hepatic decompensation (ascites, variceal hemorrhage and hepatic encephalopathy). The ability of MRE to differentiate stages of fibrosis was examined in a subset of patients who underwent a liver biopsy (n = 20).Results:An LS of 4.93 kPa was the optimal point to detected F4 fibrosis (sensitivity, 1.00; 95% confidence interval (CI), 0.40–1.00; specificity, 0.94; 95%CI, 0.68–1.00). While a serum alkaline phosphatase <1.5 times the upper limit of normal excluded the presence of advanced LS, it was not associated with the primary endpoint (hazard ratio, 0.26; 95%CI, 0.01–1.33). However, LS was associated with the development of decompensated liver disease (hazard ratio, 1.55; 95%CI, 1.41–1.70). The optimal LS thresholds that stratified patients at a low, medium and high risk for hepatic decompensation were <4.5, 4.5–6.0 and >6.0 kPa (respectively).Conclusion:Magnetic resonance elastography is able to detect cirrhosis with high specificity and an alkaline phosphatase <1.5 times the upper limit of normal makes the presence of advanced LS unlikely. Moreover, LS obtained by MRE is predictive of hepatic decompensation in PSC.
Association Between Objectively Measured Physical Activity and Cognitive Function in Older Adults—The Reasons for Geographic and Racial Differences in Stroke Study
Authors: Zhu Wenfei , Howard Virginia J. , Wadley Virginia G. , Hutto Brent , Blair Steven N. , Vena John E. , Colabianchi Natalie , Rhodes David , Hooker Steven P. 
Published: December 2015

ObjectivesTo examine the relationship between objectively measured physical activity (PA) and cognitive function in white and black older adults.DesignCross‐sectional.SettingREasons for Geographic and Racial Differences in Stroke (REGARDS) study.ParticipantsOlder adults who provided valid data from accelerometer and cognitive function tests (N = 7,098).MeasurementsAccelerometers provided estimates of PA variables for 4 to 7 consecutive days. PA cut‐points of 50 counts per minute (cpm) and 1,065 cpm were applied to differentiate between being sedentary and light PA and between light and moderate to vigorous PA (MVPA), respectively. Prevalence of cognitive impairment was defined using the Six‐Item Screener (<4/6). Letter fluency, animal fluency, word list learning, and Montreal Cognitive Assessment (orientation and recall) were used to assess memory and executive function.ResultsOf 7,098 participants (aged 70.1 ± 8.5, 54.2% female, 31.5% black), 359 (5.1%) had impaired cognition within ±12 months of PA measurement. The average proportion of time spent in MVPA (MVPA%) was 1.4 ± 1.9%. Participants in the highest quartile of MVPA% (~258.3 min/wk) were less likely to be cognitively impaired than those in the lowest quartile (odds ratio = 0.65, 95% confidence interval = 0.43–0.97). MVPA% was also significantly associated with executive function and memory z‐scores (P < .001). Similar analyses of proportion of time spent in light PA (LPA%) and sedentary time (ST%) showed no significant associations with cognitive function.ConclusionHigher levels of objectively measured MVPA%, rather than LPA% or ST%, were associated with lower prevalence of cognitive impairment and better performance in memory and executive function in aging people. The amount of MVPA associated with lower prevalence of cognitive impairment is consistent with meeting PA guidelines.
Practical limitations of superresolution imaging due to conventional sample preparation revealed by a direct comparison of CLSM, SIM and dSTORM
Authors: BACHMANN MICHAEL , FIEDERLING FELIX , BASTMEYER MARTIN 
Published: December 2015

SummaryWe evaluate the suitability of conventional sample preparation and labelling methods for two superresolution techniques, structured illumination microscopy and direct stochastic optical reconstruction microscopy, by a comparison to established confocal laser scanning microscopy. We show that SIM is compatible with standard fixation procedures and immunofluorescence labelling protocols and improves resolution by a factor of two compared to confocal laser scanning microscopy. With direct stochastic optical reconstruction microscopy, fluorophores can theoretically be localized with much higher precision. However, in practice, with indirect immunofluorescence labelling density can be insufficient due to the bulky probes to reveal biological structures with high resolution. Fine structures like single actin fibres are in fact resolved with direct stochastic optical reconstruction microscopy when using small affinity probes, but require proper adjustment of the fixation protocol. Finally, by a direct comparison of immunofluorescent and genetic labelling with fluorescent proteins, we show that target morphology in direct stochastic optical reconstruction microscopy data sets can differ significantly depending on the labelling method and the molecular environment of the target.