bluuebunny/crossref_metadata_2025_split huggingface dataset:
Numerical Games and Officials’ Achievements
Authors: Ma Qingyu 
Published: December 2016

This case study describes the conditions under which some local Chinese officials may use annual statistics work as overstate their achievements in order to earn praise and promotions. a county-level city in Hubei province of China, reported that the average income of its villagers steadily since 1996. For this the county officials were praised and rewarded time and again. But behind this achievement the plot of stretching the veracity of the numbers. This paper examines weaknesses in the system that have permitted the official to falsely report the statistics: AgricuItural data is not derived from an independent agency: the measure of economic growth in the countryside is too closely measure of the achievement of the government officials; and the present political system is ore of excessive cen- keeping the professional future of the local officials under (he control of the more senior leaders, as opposed to the common people who have elected them. These there factors have worked together to create a numbers game in Dan City.
Government matters more than ever: Toward respect for government in an increasingly privatized world
Authors: Hamilton Mary R. 
Published: December 2016

This article argues that, in our raplidly changing, increasingly complex world, government matters. It always has and arguably now matters more than ever largely because of the context within we live - a context in which more than two decades of government bashing have taken their toll on pride and capacity in public service, leaving an emasucilated public sector to deal with the immense challeges of today's world. To make this argument the historical shifts of perspective on government and the marketplace are described along with the changes occuring so rapidly in our world. Second, the impact of the recent shift to a pro-marketplace bias and the impacts of globalization, interdependence and increased tribalism on governments and on public administration are described. Finally, some key challenges facing public administration as a result of these changes are discussed.
Endogenous economic growth in China
Authors: Tan Qingshan 
Published: December 2016

China has enjoyed spectacular economic growth over the past twenty years or so. However, Chinese regional economic development has relied on forein direct investment, export-oriented industralization, and other traditional growth models. While China can perhaps continue to rely on exports, cheap labor, and a huge domestic market for foreing invetment for some time to come, sooner or later the question will arise: How long can China sustain economic growth based on her current strategies?We propose in this article the endogenous growth model as an alternative and long-term growth strategy, and focus largely on its treatment of knowledge as an independent factor of production in Chinese regional economies. This article thus proposes a new institutional framework defined as a trilateral commission. The commissioners are designed to advise and enhance communication between local and regional government leaders and administrators on knowledge-based collaboration and coordination among business, government, and the research community, as well as on the issue of knowlege generation and utilization.
Blood Calcification Propensity, Cardiovascular Events, and Survival in Patients Receiving Hemodialysis in the EVOLVE Trial
Authors: Pasch Andreas , Block Geoffrey A. , Bachtler Matthias , Smith Edward R. , Jahnen-Dechent Wilhelm , Arampatzis Spyridon , Chertow Glenn M. , Parfrey Patrick , Ma Xiaoye , Floege Juergen 
Published: December 2016

Background and objectives
Patients receiving hemodialysis are at risk of cardiovascular events. A novel blood test (T
50 test) determines the individual calcification propensity of blood.

Design, setting, participants, & measurements

T
50 was determined in 2785 baseline serum samples of patients receiving hemodialysis enrolled in the Evaluation of Cinacalcet Therapy to Lower Cardiovascular Events (EVOLVE) trial and the T
50 results were related to patient outcomes.

Results
Serum albumin, bicarbonate, HDL cholesterol, and creatinine were the main factors positively/directly and phosphate was the main factor negatively/inversely associated with T
50. The primary composite end point (all-cause mortality, myocardial infarction [MI], hospitalization for unstable angina, heart failure, or peripheral vascular event [PVE]) was reached in 1350 patients after a median follow-up time of 619 days. After adjustments for confounding, a lower T
50 was independently associated with a higher risk of the primary composite end point as a continuous measure (hazard ratio [HR] per 1 SD lower T
50, 1.15; 95% confidence interval [95% CI], 1.08 to 1.22; P<0.001). Furthermore, lower T
50 was associated with a higher risk in all-cause mortality (HR per 1 SD lower T
50, 1.10; 95% CI, 1.02 to 1.17; P=0.001), MI (HR per 1 SD lower T
50, 1.38; 95% CI, 1.19 to 1.60; P<0.001), and PVE (HR per 1 SD lower T
50, 1.22; 95% CI, 1.05 to 1.42; P=0.01). T
50 improved risk prediction (integrated discrimination improvement and net reclassification improvement, P<0.001 and P=0.001) of the primary composite end point.

Conclusions
Blood calcification propensity was independently associated with the primary composite end point, all-cause mortality, MI, and PVE in the EVOLVE study and improved risk prediction. Prospective trials should clarify whether T
50-guided therapies improve outcomes.
Parcours d’inclusion de jeunes enfants en situation de handicap en maternelle : rapport(s) au cadre des règles de vie de classe
Authors: Janner-Raimondi Martine , Bedoin Diane 
Published: December 2016

Dix ans après l’adoption de la loi du 11 février 2005, cet article propose un éclairage sur les transformations qualitatives induites dans les écoles maternelles par l’inclusion des jeunes enfants en situation de handicap. À partir d’un double cadre théorique, phénoménologique et interactionniste, il s’agit d’analyser les leviers et les freins à l’inclusion scolaire et sociale des jeunes enfants en situation de handicap en classe ordinaire. Le corpus recueilli est constitué d’entretiens semi-directifs menés auprès de professionnels de la petite enfance non spécialisés (directrices d’école, enseignants et auxiliaires de vie scolaire) et d’observations de classe filmées dans deux classes de maternelle. L’analyse croisée des données permet de saisir le sens attribué à un parcours d’inclusion et de voir les transformations des pratiques professionnelles qui en découlent. Les résultats exploratoires formulés permettent de repérer en quoi un cadre partagé par tous les acteurs et modulable en fonction des besoins éducatifs particuliers est susceptible de favoriser le processus d’inclusion.
« Outiller » les enseignants spécialisés, un enjeu de formation pour des pratiques inclusives renouvelées ?
Authors: Leroyer Laurence 
Published: December 2016

Afin de mieux comprendre les pratiques des enseignants spécialisés, nous avons mené une recherche sur les pratiques évaluatives des enseignants exerçant en ULIS (Unité localisée pour l’inclusion scolaire). Cette recherche, dont le cadre théorique se réfère à la double approche de Robert et Rogalski (2002) se fonde sur huit entretiens compréhensifs (Kaufmann, 2014). Les résultats montrent un déficit de connaissances et de ressources et, pour certains, une conception de l’évaluation dissociée des aspects didactiques. Se pose alors la question de la formation, d’autant plus importante quand celle-ci semble parfois secondaire aux yeux des personnes interrogées. Il apparaît aussi que les pratiques collaboratives font défaut, mais qu’une certaine diffusion des savoirs se met en place : lorsque les enseignants spécialisés sont « ressources », des enseignants non spécialisés s’approprient des gestes adaptés en direction des élèves inclus permettant l’accessibilité pédagogique. En lien avec les recherches centrées sur la thématique des ressources pour enseigner, « outiller » les enseignants spécialisés émerge alors comme un nouvel enjeu de formation, au service de l’école inclusive.
Pratiques inclusives en milieu ordinaire : accessibilité didactique et régulations
Authors: Suau Géraldine , Assude Teresa 
Published: December 2016

Dans le sillage de la théorie anthropologique du didactique (Chevallard, 1999) et de la théorie de l’action conjointe (Sensevy & Mercier, 2007 ; Sensevy, 2011), notre article a comme but de poursuivre l’étude de l’accessibilité didactique définie comme l’ensemble des conditions qui permettent aux élèves d’avoir accès aux savoirs. Cette étude est faite à partir du point de vue de la dynamique topogénétique, soit de la manière dont le partage des responsabilités des tâches et les positions de l’enseignant et des élèves influencent l’accès aux savoirs. Pour cela, nous prenons appui sur une séance ordinaire d’enseignement en mathématiques et sur les récits tenus par les acteurs, et nous observons les phénomènes liés à la forme d’étude du travail en petit groupe et aux régulations apportées par l’enseignant et/ou par des élèves. Nos questions sont : quelles sont les situations « favorables » pour rendre possible l’accès au savoir ? Quels sont la place et le rôle des acteurs (enseignant-élèves) pour créer des conditions d’accessibilité didactique ? Les réponses à ces questions mettent en évidence différents types de régulations topogénétiques, et leurs effets sur l’engagement ou non de l’élève en situation de handicap dans le travail mathématique.
Difficultés de l’éducation inclusive en République tchèque : les besoins éducatifs particuliers, entre défauts et troubles
Authors: Kohout-Diaz Magdalena 
Published: December 2016

En République tchèque comme en France, l’approche inclusive est étayée par la définition de besoins éducatifs particuliers. Cette nomenclature peine cependant à s’imposer tant elle est articulée aux troubles de la santé et spécialement de la santé mentale. De quelles évolutions sociohistoriques les orientations actuelles sont-elles tributaires ? Sur quelles logiques et classifications s’appuient-elles ? Quel est l’impact inclusif des approches réelles ? À partir de données ethnographiques, l’étude montre trois difficultés : le paradoxe de la reconnaissance des particularités, le flou des nomenclatures et leur étayage sur les troubles mentaux. Elle met en valeur l’accentuation de perspectives sanitaires, particulièrement en ce qui concerne le comportement ou les origines socioculturelles. La question de leur efficience en matière d’inclusion reste posée. Le souci louable mais parfois rhétorique de non-discrimination peut aboutir in fine à rabattre les conduites déviantes sur l’anormalité pathologique du trouble mental.
Dix années de politique inclusive à l’école : quel bilan ?
Authors: Chevallier-Rodrigues Émilie , Courtinat-Camps Amélie , de Léonardis Myriam 
Published: December 2016

Cette note a pour objectif de synthétiser les fondements du paradigme inclusif et de souligner les controverses qui le traversent. Depuis la loi du 11 février 2005, la prise en charge des élèves en situation de handicap vise l’accessibilité à la scolarisation et à la vie sociale, la participation civique de tous et le droit à la compensation. Face au passage d’un modèle intégratif à un modèle inclusif, les professionnels, même s’ils en soulignent la faisabilité, se retrouvent quelquefois en difficulté dans leur pratique. Ce paradigme inclusif ne peut opérer sans la mise à disposition de moyens conséquents pour la formation des professionnels et de pratiques coopératives entre les différents acteurs concernés. Les résultats des différentes études, concernant les effets de l’inclusion sur le développement cognitif et socioaffectif des élèves, ne font pas consensus. Les pistes de travail possibles pour la poursuite de l’inclusion se centrent sur diverses pratiques innovantes tant pour la formation des professionnels que pour les adaptations pédagogiques et ce, dans le but de s’inscrire dans une pratique inclusive « raisonnée ».
MARCH1 E3 Ubiquitin Ligase Dampens the Innate Inflammatory Response by Modulating Monocyte Functions in Mice
Authors: Galbas Tristan , Raymond Maxime , Sabourin Antoine , Bourgeois-Daigneault Marie-Claude , Guimont-Desrochers Fanny , Yun Tae Jin , Cailhier Jean-François , Ishido Satoshi , Lesage Sylvie , Cheong Cheolho , Thibodeau Jacques 
Published: December 2016

Abstract
Ubiquitination was recently identified as a central process in the pathogenesis and development of numerous inflammatory diseases, such as obesity, atherosclerosis, and asthma. Treatment with proteasomal inhibitors led to severe side effects because ubiquitination is heavily involved in a plethora of cellular functions. Thus, new players regulating ubiquitination processes must be identified to improve therapies for inflammatory diseases. In addition to their role in adaptive immunity, endosomal MHC class II (MHCII) molecules were shown to modulate innate immune responses by fine tuning the TLR4 signaling pathway. However, the role of MHCII ubiquitination by membrane associated ring-CH-type finger 1 (MARCH1) E3 ubiquitin ligase in this process remains to be assessed. In this article, we demonstrate that MARCH1 is a key inhibitor of innate inflammation in response to bacterial endotoxins. The higher mortality of March1−/− mice challenged with a lethal dose of LPS was associated with significantly stronger systemic production of proinflammatory cytokines and splenic NK cell activation; however, we did not find evidence that MARCH1 modulates LPS or IL-10 signaling pathways. Instead, the mechanism by which MARCH1 protects against endotoxic shock rests on its capacity to promote the transition of monocytes from Ly6CHi to Ly6C+/−. Moreover, in competitive bone marrow chimeras, March1−/− monocytes and polymorphonuclear neutrophils outcompeted wild-type cells with regard to bone marrow egress and homing to peripheral organs. We conclude that MARCH1 exerts MHCII-independent effects that regulate the innate arm of immunity. Thus, MARCH1 might represent a potential new target for emerging therapies based on ubiquitination reactions in inflammatory diseases.
Silk Sericin‐based ROS‐Responsive Oxygen Generating Microneedle Platform Promotes Angiogenesis and Decreases Inflammation for Scarless Diabetic Wound Healing
Authors: Liu Huan , Qin Sumei , Zhang Hongyan , Chen Zhongyin , Zhao Yiwei , Liu Jia , Deng Yan , Liu Miaodeng , Chen Wei , Wang Zheng , Wang Lin 
Published: September 2024

AbstractDiabetic foot ulcer typically undergoes a delayed wound‐healing process owing to the disordered microenvironment, including persistent inflammation, long‐term hypoxia, and excessive fibrosis, eventually leading to severe disabilities and other poor outcomes. However, current strategies cannot meet the dynamic demands during the wound‐healing process. Herein, a reactive oxygen species (ROS)–responsive oxygen‐generating microneedle platform, consisting of a sericin‐based glucose‐responsive hydrogel loaded with verteporfin, for effective diabetic wound healing is proposed. Under a highly oxidative microenvironment, the functionalized sericin protein depletes overproduced ROS to generate oxygen, which can not only alleviate the hypoxic microenvironment and promote angiogenesis by activating extracellular signal‐regulated kinase and Heme Oxygenase‐1 pathways but also decrease the expression of proinflammatory cytokines. Moreover, the hyperglycaemic condition triggers the gradual dissociation of this microneedle platform and promotes the release of verteporfin to enhance scarless re‐epithelization via inhibiting the yes‐associated protein signal. This versatile sericin microneedle system integrates advantageous features including inflammation alleviation, angiogenesis promotion, and scar inhibition capabilities, accelerates diabetic wound repair in vivo, and offers a novel approach for oxygen self‐supply and wound microenvironment remodeling.
Impact of soil spatial variability on young almond trees: A case study on heavy clay soils
Authors: Ballester Carlos , Filev‐Maia Rodrigo , Hornbuckle John 
Published: September 2024

AbstractThe viability of modern horticulture heavily relies on adopting sustainable practices. Understanding soil spatial variability on heavy clay soils and its impact on young trees is crucial to design suitable soil and water management strategies that guarantee the sustainability of orchards. The objective of this study was to assess in an orchard with heavy clay soils of the Riverine Plain, NSW, the impact of soil spatial variability on the development of young almond (Prunus dulcis (Mill.) D. A. Webb) trees and evaluate the use of remote and proximal sensing tools for identifying threatening factors for the sustainability of the crop. Soil and aerial surveys were used to assess the soil and crop spatial variability in an 8.3‐ha irrigation block. The site was divided into five areas based on apparent electrical conductivity (ECa) measurements where soil samples were collected. Tree growth, soil, and plant water status were monitored in two contrasting areas in ECa. In the first year of study, a significant and positive correlation was found between ECa and percentage of ground canopy cover. Soil analysis and soil moisture monitoring revealed that high values of exchangeable sodium percentage, which are indicative of sodic soils prone to dispersion, and limited water infiltration were the cause of the reduced tree growth in areas with low ECa. The impact of soil spatial variability on tree growth decreased in the second growing season due to weather and water management factors that influenced soil water content. This study showcases the usefulness of remote and proximal sensing in assessing potential soil‐spatial‐related issues in newly established orchards as well as the impact soil spatial variability can have on tree development in the first years after planting.
Aggregation‐induced circularly polarized luminescence and delayed fluorescence enabled by activating high‐level reverse intersystem crossing
Authors: Wang Ke , Ou Xinwen , Niu Xiaofei , Wang Zhenghao , Song Fengyan , Dong Xiaobin , Guo Wu‐jie , Peng Hui‐Qing , Zhao Zujin , Lam Jacky W. Y. , Sun Jianwei , Wu Hongkai , Yu Shu‐Yan , Li Fei , Tang Ben Zhong 
Published: September 2024

AbstractCircularly polarized luminescence (CPL) materials with delayed fluorescence have attracted much attention due to their ability to efficiently trap triplet state excitons, thereby improving the photoluminescence quantum yields of CPL materials. However, much effort has been normally focused on the utilization of T1 excitons but seldom on the utilization of higher excited triplet state Tn (n > 1) excitons. Rational manipulation of higher excited triplet state Tn (n > 1) excitons and suppression of Kasha's rule of CPL materials remains a major challenge. Herein, two gold complex enantiomers ((R/S)‐BPAuBC) based on axially chiral binaphthyls and 3,6‐Di‐tert‐butylcarbazole groups are synthesized and systematically investigated. These materials exhibit aggregation‐induced circularly polarized delayed fluorescence. Circularly polarized delayed fluorescence was found to be enabled by activating high‐level reverse intersystem crossing (hRISC). The anti‐Kasha phosphorescence at 77 K proves that the exciton has a large population in the high‐lying triplet state T2, which allows the effective hRISC process to cross back to the singlet state S1 and emit delayed fluorescence. In addition, CPL “on–off” switching is further achieved in nanoparticles by acid–base stimulus, showing its potential as an acid–base responsive material.
The Impact of the COVID‐19 Pandemic on the Sex Ratio at Birth in Ireland
Authors: Masukume Gwinyai , Non Amy L. , Cleaver Peyton , Grech Victor 
Published: September 2024

ABSTRACTObjectivesThe sex ratio at birth (SRB), calculated as male divided by total live births, is an important indicator of population health. Typically, male live births slightly outnumber female live births. Population events, including pandemics, can alter the SRB, with effects sometimes evident 9 months post‐event, potentially due to changes in sexual behavior and/or stress levels. This study investigates the impact of the COVID‐19 pandemic on the SRB in the Republic of Ireland.MethodsPublicly available monthly live birth data for Ireland were obtained from the Central Statistics Office for the period 2015 to 2021. Time series analysis predicted the SRB for 2020 using data from 2015 to 2019, with comparisons made between observed and predicted values.ResultsIn December 2020, 9 months after the March 2020 COVID‐19 declaration, the observed SRB sharply fell to 49.44% (97.80 males for every 100 females), below the 95% prediction interval of 50.31% to 52.15%, significantly deviating from the expected male predominance. December 2020 also recorded the lowest average daily number of births (n = 145) in the study period.ConclusionThe sharp decline in the SRB in December 2020, alongside the lowest birth count, suggests reduced sexual intercourse at the population level, particularly in March 2020, aligning with recommendations from Ireland's Health Service Executive (HSE). The HSE advocated precautionary measures such as limiting partnered sex in March 2020 to mitigate the spread of COVID‐19. These findings highlight the pandemic's potential impact on population dynamics and stress the importance of SRB monitoring as a low‐cost and readily available health indicator, especially during national crises.
Associations between the multitrajectory neuroplasticity of neuronavigated rTMS‐mediated angular gyrus networks and brain gene expression in AD spectrum patients with sleep disorders
Authors: Yao Weina , Hou Xinle , Zhou Huijuan , You Shengqi , Lv Tingyu , Chen Haifeng , Yang Zhiyuan , Chen Chang , Bai Feng 
Published: September 2024

AbstractINTRODUCTIONThe multifactorial influence of repetitive transcranial magnetic stimulation (rTMS) on neuroplasticity in neural networks is associated with improvements in cognitive dysfunction and sleep disorders. The mechanisms of rTMS and the transcriptional‐neuronal correlation in Alzheimer's disease (AD) patients with sleep disorders have not been fully elucidated.METHODSForty‐six elderly participants with cognitive impairment (23 patients with low sleep quality and 23 patients with high sleep quality) underwent 4‐week periods of neuronavigated rTMS of the angular gyrus and neuroimaging tests, and gene expression data for six post mortem brains were collected from another database. Transcription‐neuroimaging association analysis was used to evaluate the effects on cognitive dysfunction and the underlying biological mechanisms involved.RESULTSDistinct variable neuroplasticity in the anterior and posterior angular gyrus networks was detected in the low sleep quality group. These interactions were associated with multiple gene pathways, and the comprehensive effects were associated with improvements in episodic memory.DISCUSSIONMultitrajectory neuroplasticity is associated with complex biological mechanisms in AD‐spectrum patients with sleep disorders.Highlights
This was the first transcription‐neuroimaging study to demonstrate that multitrajectory neuroplasticity in neural circuits was induced via neuronavigated rTMS, which was associated with complex gene expression in AD‐spectrum patients with sleep disorders.
The interactions between sleep quality and neuronavigated rTMS were coupled with multiple gene pathways and improvements in episodic memory.
The present strategy for integrating neuroimaging, rTMS intervention, and genetic data provide a new approach to comprehending the biological mechanisms involved in AD.