bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevention of Recurrent Spontaneous Preterm Delivery Using Probiotics (Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis; PPP Trial): Protocol for a Prospective, Single-Arm, Nonblinded, Multicenter Trial
Authors: Yoneda Satoshi , Kobayashi Tohru , Kikuchi Kayoko , Iwamoto Shintaro , Teramoto Tsuyoshi , Chujo Daisuke , Otsuki Katsufumi , Nakai Akihito , Saito Shigeru 
Published: September 2024

Background
The rate of recurrent spontaneous preterm delivery (sPTD) ranges between 27% and 34% and is 22.3% in Japan. Although it currently remains unclear whether probiotics prevent sPTD, retrospective studies recently reported a reduction in the rate of recurrent sPTD with the administration of probiotics including Clostridium spp., which induce regulatory T cells that play an important role in maintaining pregnancy.

Objective
The objective of this trial is to evaluate the preventative effects of available oral probiotics, including Clostridium butyricum, on recurrent sPTD.

Methods
This is a prospective, single-arm, nonblinded, multicenter trial in Japan. The sample size required for this trial is 345 pregnant women with a history of sPTD, considering a clinically significant reduction in the relative risk of 30% (risk ratio=0.7). The primary endpoint is the rate of recurrent sPTD at <37 weeks of gestation. The secondary endpoints are the rate of sPTD at <34 weeks of gestation, the rate of recurrent sPTD at <28 weeks of gestation, the ratio of intestinal Clostridium spp. (detected by next-generation sequencing), and bacterial vaginosis (using the Nugent score).

Results
The trial procedures were approved by the Clinical Research Review Board of Toyama University Hospital (SCR2020008) on March 31, 2021. The trial was registered on the Japan Registry of Clinical Trial website on April 28, 2021. Recruitment began on May 1, 2021, and the trial is estimated to finish on March 31, 2025.

Conclusions
The findings will clarify the rate of recurrent sPTD following probiotic administration including Clostridium butyricum. Outcomes from this trial will inform clinical practice and guide future randomized controlled trials.

Trial Registration
Japan Registry of Clinical Trials jRCTs041210014; https://jrct.niph.go.jp/latest-detail/jRCTs041210014

International Registered Report Identifier (IRRID)
DERR1-10.2196/59928
Experiences of Social Isolation and Loneliness in Chronic Kidney Disease
Authors: Sluiter Amanda , Cazzolli Rosanna , Jaure Allison , Scholes-Robertson Nicole , Craig Jonathan C. , Johnson David W. , Gonzalez Andrea Matus , Sautenet Benedicte , Smith Ben J. , Manera Karine ,   for the SONG initiative
Published: September 2024

Key Points

Loneliness and social isolation are increasingly recognized as global public health issues; however, little is known about the patient and caregiver experience in CKD.We used qualitative data to explore the experiences of loneliness and social isolation from the perspective of patients and caregivers.

Background
Many patients with CKD experience loneliness and social isolation, which are associated with a higher risk of mortality, morbidity, and poor mental health. We aimed to describe the perspectives of patients with CKD and their caregivers on loneliness and social isolation, to inform strategies to increase social participation.

Methods
A secondary analysis of qualitative data from the Standardized Outcomes in Nephrology initiative dataset (36 focus groups, three Delphi surveys, and seven consensus workshops) was conducted. We extracted and thematically analyzed data from patients with CKD, including those receiving hemodialysis or peritoneal dialysis and those with a kidney transplant, as well as their caregivers, on the perspectives and experiences of loneliness and social isolation.

Results
Collectively, the studies included 1261 patients and caregivers from 25 countries. Six themes were identified: restricted by the burdens of disease and treatment (withdrawing from social activities because of fatigue, consumed by the dialysis regimen, tethered to treatment, travel restrictions); external vulnerability (infection risk, anxiety of dining out); diminishing societal role (grieving loss of opportunities, social consequences of inability to work); fending for oneself in health care (no one to relate to, lost in uncertainty, unmet psychosocial needs); undermining self-esteem (unable to engage in activities which previously defined self, shame and self-consciousness about appearance, hindering confidence for intimate relationships); and feeling ostracized (disconnected by family and friends, fear of stigma and being misunderstood, guilt of burdening others).

Conclusions
For patients with CKD and their caregivers, social participation is substantially impaired by the burden of CKD and its treatment and fear of risks to health such as infection. This undermines patient and caregiver mental health, particularly self-esteem and sense of belonging. Additional interventions are needed to improve social connections among people with CKD and their caregivers.
La buena fe exenta de culpa: utopía de los opositores ante las decisiones del Tribunal Superior del Distrito de Cúcuta- Sala Civil Especializada en Restitución de Tierras
Authors: Bohórquez Galviz Cristian Antonio 
Published: September 2024

Este artículo sobre los procesos de restitución de tierras en Colombia establecidos en la Ley 1148 del 2011, nos muestra de donde proviene estos procesos que se contemplan como medidas de reparación para las víctimas del conflicto armado, se establecen su dos etapas procesales: administrativas y judicial, así como recursos y mecanismos utilizados por los opositores que son los actuales titulares de los predios en disputa y que dentro del término de 15 días realiza la contestación oponiéndose a pretensiones para su reconocimiento y finaliza con los parámetros para configurar los elementos objetivos de la buena fe exenta de culpa en los fallos expedidos por el Tribunal Superior de Distrito Judicial, Sala Civil Especializada en Restitución de tierras de la ciudad de Cúcuta en la compra de predios rurales del departamento del Cesar, es una investigación documental con técnica interpretativa, analítica propia de las ciencias sociales, en donde se aplicó la metodología hermenéutica jurídica con la revisión legal de la jurisprudencia para resolver la pregunta problema y así poder establecer la conclusión sobre la buena fe exenta de culpa como una utopía de los opositores ante decisiones jurisprudenciales en salas especializadas de restitución de tierras de Norte de Santander.
The Transfigured Guitar of Alberto Ginastera Sonata for Guitar, op. 47
Authors: Silvia Escamilla Jiménez  
Published: September 2024

This research takes as a starting point the Alberto Ginastera's Sonata for Guitar, op. 47 (1976) The Sonata represents, within Ginastera's musical trajectory, an example of synthesis of his work, due to the variety of compositional and motivic material that he manages to link. Its interest relies in the way in which avant-garde compositional techniques, such as serialism or twelve-tone technique, are mixed with folklore rhythms and popular elements typical of Argentine traditional music.
It offers the opportunity to verify in his compositional practice the theoretical approaches on music that the composer had presented in his previous works. Discovering the origin of the thematic and rhythm sources of the Sonata for Guitar by Ginastera is an invitation to inquire in the valuable atmosphere of Argentine folklore.
Since its premiere, the Sonata has attracted increasing interest for its innovative contributions to contemporary music. The result is a tribute to the guitar, the Argentine folk music and the avant-garde music. As far as the guitar as an instrument is concerned, in it the composer explores a great variety of innovative resources that verify its suitability to transmit the contents of contemporary music, while at the same time pays off the debt it had with Argentine folklore, present in its rhetoric and symbolically evoked, but now transfigured into a reality.
Finally, this research presents some connections between this guitar piece and the String Quartet No. 1, op. 20, that Ginastera composed more than twenty years before.
Monteverdi’s lamenti and lettere amorose and the pre-existing art of declamation
Authors: Judith Sepulchre  
Published: September 2024

« Should the interpretation of Monteverdi’s lamenti and lettere amorose be closer to the pre-existing art of declamation? »

Nowadays, Monteverdi has become so sacred to the Early musician, that we are afraid of disturbing his art in our interpretation of his written down musical lines. So we stick to what is written, respecting every pitch, every note value, and God forbid we change the tactus! For a lot of Monteverdi’s music, this is a respectable approach. However, when it comes to the interpretation of his lamentations (lamenti) and love letters (lettere amorose), one asks themselves whether it should perhaps be done in a more declamative way. These two genres are composed in the stile recitativo and carry so much unrepeated text that it seems almost improbable that one should approach these compositions from the notes rather than from the poetry. If the seconda pratica is the beginning reign of the text over the harmony in the composition process, then why not adopt this same concept in the interpretation process?

Throughout this research, I will first observe the historical context of these two genres and their connections with the world of the Commedia dell’Arte. I will then discuss the very delicate question of the tactus. And finally, I will attempt to interpret a couple of Monteverdi’s compositions, basing myself on the declamation skills of a Commedia dell’Arte specialist with whom I worked closely.
Onset and progression of dental erosion in a mouse model
Authors: Marie Haabeth Brox Julie , Tulek Amela , Sehic Amer , Mulic Aida , Paaske Utheim Tor , Khan Qalbi 
Published: September 2024

Objective: Purpose of this research was to examine the onset, progression and wear rates of dental erosion in an established mouse model.
Material and methods: Dental erosion in mice was experimentally induced, and the acidic effects of cola drink on their teeth after 2, 4 and 6-weeks were closely analysed by scanning electron microscopy. The tooth height and enamel or dentin loss were established.
Results: The dental erosion on the molars showed clear progression from 2 to 6 weeks. By the 2-week mark, a significant portion of enamel was already eroded, revealing the dentin on the lingual cusps. When adjusted for attritional wear, molars exposed to cola for 2 weeks showed a 35% drop in lingual tooth height compared to controls (533 μm vs. 818 μm). At 4 and 6 weeks, the cola-exposed group continued to display decreased lingual tooth heights by 40% (476 μm vs. 799 μm) and 43% (440 μm vs. 767 μm), respectively.
Conclusion: This study revealed significant acidic effects of cola drink on mouse molars as early as 2 weeks. These findings highlight the challenge of monitoring dental erosion clinically and underscore the importance of early preventive and intervention measures.
Media Pembelajaran Kincir Pintar (KINTAR) terhadap Keterampilan Membaca Nyaring Siswa Kelas II Sekolah Dasar
Authors: Ketut Ninda Putri Ayuni  , Dewa Gede Firstia Wirabrata  
Published: September 2024

Permasalahan yang terjadi di sekolah dasar yaitu minat siswa dalam mmebaca masih rendah. Hal ini terlihat dari siswa yang masih takut, ragu-ragu, serta kurang percaya diri dalam membaca nyaring. Melihat hal tersebut perlu adanya inovasi yang mampu meningkatkan minat membaca siswa salah satunya dengan menggunakan media pembelajaran untuk membantu siswa dalam belajar. Sehingga penelitian ini bertujuan untuk menganalisis pengaruh media pembelajaran kincir pintar terhadap keterampilan membaca nyaring siswa kelas II SD. Rancangan yang digunakan yaitu penelitian kuantitatif dengan desain eksperimen semu (quasi eksperiment). Populasi dalam penelitian ini adalah siswa kelas II yang berjumlah 135 siswa. Sampel dalam penelitian ini ditentukan dengan teknik Random Sampling kemudian dilakukan post-test untuk kelas eksperimen yaitu siswa kelas II berjumlah 17 siswa dan kelas berjumlah 20 siswa. Pengumpulan data dalam penelitian ini menggunakan metode tes unjuk kerja. Instrumen yang digunakan untuk mengukur keterampilan membaca nyaring kelas II SD berupa tes unjuk kerja yang digunakan untuk mengukur aspek psikomotorik sebanyak 1 paragraf cerita dan 1 syair lagu. Setelah data terkumpul kemudian dianalisis menggunakan metode analisis deskriptif yang dilakukan dengan mencari rerata skor, median, dan modus. Teknik analisis data yang digunakan untuk menganalisis data hasil penelitian adalah teknik analisis independent t-test. Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat pengaruh yang signifikan mengenai media pembelajaran kincir pintar terhadap keterampilan membaca nyaring siswa kelas II SD. Implikasi dari penelitian ini yakni diharapkan mampu membantu siswa dan guru dalam menghadirkan pembelajaran yang menyenangkan.
Evaluating Methyl Salicylate Lures on Natural Enemies, Pests and Meristem Damage in Red Maple Fields
Authors: Butcher Alexander M. , Rendon Dalila , Harrington Sinaiah , Lee Jana C. 
Published: September 2024

Abstract
Red maple seedlings transplanted in spring must grow vertically quickly and insecticides are applied to prevent meristem damage. While sprays have achieved desired results, sustainable options are being sought. Methyl salicylate (MeSA) is a common herbivore-induced plant volatile that is available as a commercial lure to attract natural enemies into farms. We conducted a 2-year field study to determine if MeSA-treated plots had more natural enemies, fewer insect pests, and less meristem damage. The only natural enemy detected in statistically higher abundance within MeSA plots was the minute pirate bug (Orius spp.), a predator of thrips (Thripidae) and aphids (Aphidae). However, this increase in abundance was only higher during the end of the second-year trial. Abundance of aphid alates was statistically lower in MeSA blocks 2 weeks after application. No other pests were significantly lower in MeSA-treated than control plots. Meristem damage in MeSA blocks was lower overall in the first year, and for the first 3 weeks in the second-year trial. While MeSA was associated with significantly less meristem damage, the mechanism was not clear from arthropod samples and potential reasons are discussed.
Species used in this study: red maple (Acer rubrum L.); minute pirate bug (Orius spp.).
Chemicals used in this study: Methyl salicylate (Predalure).
Iatrogenic migration of iliac stent graft that was implanted for the reason of iliac artery perforation at the beginning of TAVI into the ascending aorta during the procedure
Authors: Hudák Marek , Koščo Martin , Rašiová Maria 
Published: September 2024

Abstract

Introduction
Vascular complications are one of the substantial complications of transcatheter aortic valve implantation (TAVI). Stent graft implantation is a powerful tool for managing them.

Case presentation
This article describes a case of iliac artery perforation by 10 Fr sheath in an 86-year-old female at the beginning of the TAVI procedure that was solved by stent graft implantation. However, the stent graft was later unintentionally dislocated into the ascending aorta during repeated attempts of sheath and guiding wire introduction. Finally, the migrated stent graft was successfully extracted using a loop snare device.

Conclusions
This article highlights the fact that armamentarium passage through an implanted stent graft, especially when newly deployed, can be tricky and should be done gently and carefully, optimally under fluoroscopic guidance. The permanent multidisciplinary team realizes TAVI can be advantageous for immediate management of difficult clinical situations.
Participatory Budgeting and the Formation of Public Spheres
Authors: Carmo Gisleine do , Pereira José Roberto , Rezende Vânia Aparecida , Felizardo Luiz Flávio 
Published: September 2024

Objective: Describe the role of participatory budgeting (PB) in the formation of public spheres.

Theoretical Framework: The research is based on Habermas's (2012) theory of communicative action and the formation of public spheres, along with approaches related to deliberative democracy, highlighting the role of PB as a channel for citizen engagement and social justice.

Method: The study employs a theoretical analysis to explore the connection between PB and the formation of public spheres, drawing on case studies and existing literature on PB and deliberative democracy.

Results and Discussion: The essay identifies six premises that link PB to the formation of public spheres: 1) Discussions on problem-topics influence through public spheres; 2) Public spheres strengthen deliberative democracy; 3) All citizens can participate; 4) PB enables the participation of “weak publics” and promotes social justice; 5) The educational nature of PB enhances citizen reflexivity; 6) PB exercises social control, promoting good governance and transparency.

Research Implications: The study suggests that by fostering deliberation and citizen participation, PB can strengthen local democracy and contribute to the formulation of more just and inclusive policies.

Originality/Value: This essay offers a theoretical contribution by connecting PB with the theory of communicative action and the foundations for the formation of public spheres, as proposed by Habermas (2012), highlighting its potential to strengthen democracy through deliberative citizen participation.
Production of Cellulolytic Enzymes by Paecilomyces TP08 Using Grape Stalk and Wheat Bran as Substrates in Solid State Culture
Authors: Cabral Emmely Vitória Santana , Andrade Eline de Souza Pontes , Silva Hellen Aparecida Sousa , Morais Maria Luiza Albino , Sousa Adna Cristina Barbosa de , Almeida Andréa Farias de 
Published: September 2024

Objective: The objective of this study is to investigate the use of grape stems and wheat bran as substrates in solid state fermentation, for the production of cellulolytic enzymes using the fungus Paecilomyces TP08 sp.

Theoretical Framework: In grape production, driven by increased consumption and exports, by-products represent 30% of the total volume of grapes processed for wine, requiring efficient management to ensure sustainability.

Method: The methodology adopted for this research involves solid-state cultivation, with a substrate made up of 50% grape stems and 50% wheat bran, with samples taken every 24 hours. Each sample taken went through a filtration process, followed by enzyme activity analysis using the DNS method.

Results and Discussion: The results obtained showed that the cultivation with the association of wheat bran and grape stalks presented good total cellulase activity during the process, value of 0.846 U/g in 144h, followed by the activity of 0.663U/g observed in 24h.

Research Implications: The practical and theoretical implications of this research are discussed, providing insights into how the results can be applied or influence practices in the field of industrial biotechnology. These implications could cover the food, textile and pharmaceutical industries.

Originality/Value: This study contributes to the literature by associating grape stalks with wheat bran for the production of fungal enzymes. The relevance and value of this research are evidenced by the use of an innovative substrate (grape stalks) associated with a conventional substrate (wheat bran) for induction of the microorganism little used in the literature for enzyme production.
TEHNIČKI ASPEKTI PRIKLJUČENJA FOTONAPONSKIH ELEKTRANA NA DISTRIBUTIVNI SISTEM REPUBLIKE SRBIJE
Authors: Pavić Aleksandar , Dumnić Boris 
Published: September 2024

U radu su definisani tehnički uslovi za priključenje fotonaponskih elektrana na distributivni sistem Republike Srbije. Upotrebom softverskog alata ETAP, modelovana je fotonaponska elektrana snage 990 kW i priključena na 20 kV distributivnu mrežu. Na osnovu dobijenih rezultata, sprovedena je analiza tehničkih aspekata priključenja fotonaponske elektrane na distributivni sistem.
<b>ANALISIS PENETAPAN NOMOR 53/PDT.P/2023/PN JKT.SEL MENGENAI PERMOHONAN PENCATATAN PERKAWINAN BEDA AGAMA YANG DIKABULKAN OLEH PENGADILAN NEGERI JAKARTA SELATAN</b>
Authors: Rizky Adytiya Pratama  , Muriani  
Published: September 2024

Interfaith marriage is a marriage in which a person with different religious beliefs and still respective to their religions. Formulation of the problem in this study is whether the South Jakarta District Court has the authority to examine and determine applications for registration of marriages of different religions and whether the South Jakarta District Court judge used the legal considerations used in Decision Number 53/Pdt.P/2023/PN Jkt.Sel in accordance with Law Number 1 of 1974 and the Complication of Islamic Law in granting applications for registration of marriages of different religions. The research method uses normative legal research, is analytical descriptive and data collection uses library research and deductive methods of drawing conclusions. Results of the research and discussion of the South Jakarta District Court Judges are indeed authorized to determine interfaith marriages, but even though they are authorized, the South Jakarta District Court Judges should not grant the application. Conclusion is that the South Jakarta District Court Judge uses legal considerations that are contrary to Law Number 1 of 1974 concerning Marriage, the Complication of Islamic Law and religious provisions in Indonesia and also the lack of legal considerations of judges or Onvoldoende gemotiveerd in granting applications for interfaith marriages
Expression profiling & functional characterization of candidate miRNAs in serum exosomes among Indians with & without HIV-tuberculosis coinfection
Authors: Kushwaha Shweta , Yadav Rajbala , Kumar Roopendra , Kumar Santosh , Chauhan Devendra Singh , Vir Singh Ajay 
Published: September 2024

Background & objectives
Despite the evidence of population differences in miRNA expression, limited information is available about the expression profile of miRNAs in Indian tuberculosis (TB) patients. The present study aimed to investigate the expression profile of candidate serum exosomal microRNAs in Indian patients with and without HIV-TB coinfection.

Methods
The pool samples of serum exosomes of study participants (HIV-TB coinfection, extra-pulmonary TB, HIV mono-infection, pulmonary TB) and healthy humans were processed for the isolation of total RNA followed by miRNA analysis using miRCURY LNA human focus PCR panel by real-time PCR. The significantly altered miRNAs were identified using differential expression analysis. The target genes prediction and potential functional analysis of exclusively differentially expressed miRNAs were performed using bioinformatics tools.

Results
The expression profile of 57, 58, 49 and 11 miRNAs was significantly altered in exosome samples of HIV–TB coinfected, extra-pulmonary TB, HIV mono-infected and pulmonary TB patients compared to healthy controls, respectively. The set of three (hsa-let-7i-5p, hsa-miR-24-3p, hsa-miR-92a-3p), three (hsa-miR-20a-5p, hsa-let-7e-5p, hsa-miR-26a-5p) and four (hsa-miR-21-5p, hsa-miR-19a-3p, hsa-miR-19b-3p, hsa-miR-146a-5p) miRNAs were exclusively significantly differentially expressed in study participants with HIV-TB coinfection, extra-pulmonary TB and pulmonary TB, respectively. Most of the target genes of exclusively differentially expressed miRNAs were enriched in pathways in cancer, MAPK signalling pathway and Ras signalling pathway.

Interpretation & conclusions
The present study demonstrates a distinct expression profile of miRNAs in serum exosomes of the study participants and identified crucial miRNAs which may have a significant impact on the biomarker analysis and pathogenesis of TB in Indian patients.