bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Utility of Multimarker Genetic Risk Scores for Prediction of Incident Coronary Heart Disease
Authors: Iribarren Carlos , Lu Meng , Jorgenson Eric , Martínez Manuel , Lluis-Ganella Carla , Subirana Isaac , Salas Eduardo , Elosua Roberto 
Published: October 2016

Background—
We evaluated whether including multilocus genetic risk scores (GRSs) into the Framingham Risk Equation improves the predictive capacity, discrimination, and reclassification of asymptomatic individuals with respect to coronary heart disease (CHD) risk.

Methods and Results—

We performed a cohort study among 51 954 European-ancestry members of a Northern California integrated healthcare system (67% female; mean age 59) free of CHD at baseline (2007–2008). Four GRSs were constructed using between 8 and 51 previously identified genetic variants. After a mean (±SD) follow-up of 5.9 (±1.5) years, 1864 incident CHD events were documented. All GRSs were linearly associated with CHD in a model adjusted by individual risk factors: hazard ratio (95% confidence interval) per SD unit: 1.21 (1.15–1.26) for GRS_8, 1.20 (1.15–1.26) for GRS_12, 1.23 (1.17–1.28) for GRS_36, and 1.23 (1.17–1.28) for GRS_51. Inclusion of the GRSs improved the C statistic (ΔC statistic =0.008 for GRS_8 and GRS_36; 0.007 for GRS_12; and 0.009 for GRS_51; all
P
<0.001). The net reclassification improvement was 5% for GRS_8, GRS_12, and GRS_36 and 4% for GRS_51 in the entire cohort and was (after correcting for bias) 9% for GRS_8 and GRS_12 and 7% for GRS_36 and GRS_51 when analyzing those classified as intermediate Framingham risk (10%–20%). The number required to treat to prevent 1 CHD after selectively treating with statins up-reclassified subjects on the basis of genetic information was 36 for GRS_8 and GRS_12, 41 for GRS_36, and 43 for GRS_51.

Conclusions—
Our results demonstrate significant and clinically relevant incremental discriminative/predictive capability of 4 multilocus GRSs for incident CHD among subjects of European ancestry.
Defining a Contemporary Ischemic Heart Disease Genetic Risk Profile Using Historical Data
Authors: Mosley Jonathan D. , van Driest Sara L. , Wells Quinn S. , Shaffer Christian M. , Edwards Todd L. , Bastarache Lisa , McCarty Catherine A. , Thompson Will , Chute Christopher G. , Jarvik Gail P. , Crosslin David R. , Larson Eric B. , Kullo Iftikhar J. , Pacheco Jennifer A. , Peissig Peggy L. , Brilliant Murray H. , Linneman James G. , Denny Josh C. , Roden Dan M. 
Published: October 2016

Background—
Continued reductions in morbidity and mortality attributable to ischemic heart disease (IHD) require an understanding of the changing epidemiology of this disease. We hypothesized that we could use genetic correlations, which quantify the shared genetic architectures of phenotype pairs and extant risk factors from a historical prospective study to define the risk profile of a contemporary IHD phenotype.

Methods and Results—

We used 37 phenotypes measured in the ARIC study (Atherosclerosis Risk in Communities; n=7716, European ancestry subjects) and clinical diagnoses from an electronic health record (EHR) data set (n=19 093). All subjects had genome-wide single-nucleotide polymorphism genotyping. We measured pairwise genetic correlations (rG) between the ARIC and EHR phenotypes using linear mixed models. The genetic correlation estimates between the ARIC risk factors and the EHR IHD were modestly linearly correlated with hazards ratio estimates for incident IHD in ARIC (Pearson correlation [
r
]=0.62), indicating that the 2 IHD phenotypes had differing risk profiles. For comparison, this correlation was 0.80 when comparing EHR and ARIC type 2 diabetes mellitus phenotypes. The EHR IHD phenotype was most strongly correlated with ARIC metabolic phenotypes, including total:high-density lipoprotein cholesterol ratio (rG=−0.44,
P
=0.005), high-density lipoprotein (rG=−0.48,
P
=0.005), systolic blood pressure (rG=0.44,
P
=0.02), and triglycerides (rG=0.38,
P
=0.02). EHR phenotypes related to type 2 diabetes mellitus, atherosclerotic, and hypertensive diseases were also genetically correlated with these ARIC risk factors.

Conclusions—
The EHR IHD risk profile differed from ARIC and indicates that treatment and prevention efforts in this population should target hypertensive and metabolic disease.
Variation in Hospital Use and Outcomes Associated With Pulmonary Artery Catheterization in Heart Failure in the United States
Authors: Khera Rohan , Pandey Ambarish , Kumar Nilay , Singh Rajeev , Bano Shah , Golwala Harsh , Kumbhani Dharam J. , Girotra Saket , Fonarow Gregg C. 
Published: October 2016

Background—
There has been an increase in the use of pulmonary artery (PA) catheters in heart failure (HF) in the United States in recent years. However, patterns of hospital use and trends in patient outcomes are not known.

Methods and Results—

In the National Inpatient Sample 2001 to 2012, using
International Classification of Diseases
-Ninth Revision codes, we identified 11 888 525 adult (≥18 years) HF hospitalizations nationally, of which an estimated 75 209 (SE 0.6%) received a PA catheter. In 2001, the number of hospitals with ≥1 PA catheterization was 1753, decreasing to 1183 in 2011. The mean PA catheter use per hospital trended from 4.9 per year in 2001 (limits 1–133) to 3.8 per year in 2007 (limits 1–46), but increased to 5.5 per year in 2011 (limits 1–70). During 2001 to 2006, PA catheterization declined across hospitals; however, in 2007 to 2012, there was a disproportionate increase at hospitals with large bedsize, teaching programs, and advanced HF capabilities. The overall in-hospital mortality with PA catheter use was higher than without PA catheter use (13.1% versus 3.4%;
P
<0.0001); however, in propensity-matched analysis, differences in mortality between these groups have attenuated over time—risk-adjusted odds ratio for mortality for PA catheterization, 1.66 (95% confidence interval, 1.60–1.74) in 2001 to 2003 down to 1.04 (95% confidence interval, 0.97–1.12) in 2010 to 2012.

Conclusions—
There is substantial hospital-level variability in PA catheterization in HF along with increasing volume at fewer hospitals over-represented by large, academic hospitals with advanced HF capabilities. This is accompanied by a decline in excess mortality associated with PA catheterization.
Health Status Outcomes in Patients With Acute Myocardial Infarction After Rehospitalization
Authors: Shore Supriya , Smolderen Kim G. , Kennedy Kevin F. , Jones Philip G. , Arnold Suzanne V. , Cohen David J. , Stolker Joshua M. , Zhao Zhenxiang , Wang Tracy Y. , Ho P. Michael , Spertus John A. 
Published: October 2016

Background—
Rehospitalizations after acute myocardial infarction for unplanned coronary revascularization and unstable angina (UA) are common. However, despite the inclusion of these events in composite end points of many clinical trials, their association with health status has not been studied.

Methods and Results—
We included 3283 patients with acute myocardial infarction enrolled in a prospective, 24-center US study who had rehospitalizations independently classified by experienced cardiologists. Health status was assessed using Seattle Angina Questionnaire and EuroQol-5D Visual Analog Scale. In the propensity-matched cohorts, 1-year health status was compared between those who did and did not experience rehospitalization for UA or revascularization using a hierarchical linear model. Overall, mean age was 59 years, 33% were women, and 70% were white. Rehospitalization rates for UA and unplanned revascularization at 1 year were 4.3% and 4.7%. One-year Seattle Angina Questionnaire summary scores were worse in patients with rehospitalizations for UA (mean difference, −10.1; 95% confidence interval, −12.4 to −7.9) and unplanned revascularization (mean difference, −5.7; 95% confidence interval, −8.8 to −2.5) when compared with patients without such rehospitalizations. Similarly, EuroQol-5D Visual Analog Scale scores were worse among patients with such readmissions. Individual Seattle Angina Questionnaire domains indicated worse 1-year angina and quality of life outcomes among patients rehospitalized for UA or unplanned revascularization.

Conclusions—
Within the first year after acute myocardial infarction, rehospitalizations for UA and unplanned revascularization are associated with worse health status. These findings highlight the impact of such events from a patient’s perspective, beyond their economic impact and support the use of UA and unplanned revascularization as elements of composite end points.
Histopathologic Analysis of Retrieved Thrombi Associated With Successful Reperfusion After Acute Stroke Thrombectomy
Authors: Hashimoto Tetsuya , Hayakawa Mikito , Funatsu Naoko , Yamagami Hiroshi , Satow Tetsu , Takahashi Jun C. , Nagatsuka Kazuyuki , Ishibashi-Ueda Hatsue , Kira Jun-ichi , Toyoda Kazunori 
Published: October 2016

Background and Purpose—
Histopathologic evaluation of occlusive thrombi retrieved from cerebral arteries using endovascular therapy is possible. We investigated the relationship between successful reperfusion after thrombectomy and histopathologic characteristics of retrieved thrombi.

Methods—
Among consecutive patients with acute ischemic stroke treated with endovascular therapy at our institute from December 2010 to July 2015, we retrospectively reviewed those with acute major arterial occlusion from which retrieved thrombi were evaluated histopathologically. Obtained thrombi were assessed for the existence of atheromatous gruel, organization, and the ratios of erythrocyte and fibrin/platelet components. Successful reperfusion was defined as the modified Treatment in Cerebral Ischemia grade of 2b to 3.

Results—

Of 83 patients studied, 58 (70%) underwent successful reperfusion. Atheromatous gruel was less frequently identified (3% versus 20%;
P
=0.024), and the proportion of erythrocyte components was higher (57±23% versus 47±24%;
P
=0.042) in thrombi retrieved from the reperfused than the unreperfused group. On multivariate logistic regression analysis, atheromatous gruel was inversely related (odds ratio, 0.062; 95% confidence interval, 0.002–0.864), and >64% erythrocyte components (cutoff obtained from receiver operating characteristic curve) were positively related (odds ratio, 4.352; 95% confidence interval, 1.185–19.363) to successful reperfusion.

Conclusions—
Successful reperfusion could be associated with the histopathology of occlusive thrombi, including the existence of atheromatous gruel and proportion of erythrocyte components.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02251665.
Surrogate Data Methods Based on a Shuffling of the Trials for Synchrony Detection: The Centering Issue
Authors: Albert Mélisande , Bouret Yann , Fromont Magalie , Reynaud-Bouret Patricia 
Published: October 2016

We investigate several distribution-free dependence detection procedures, all based on a shuffling of the trials, from a statistical point of view. The mathematical justification of such procedures lies in the bootstrap principle and its approximation properties. In particular, we show that such a shuffling has mainly to be done on centered quantities—that is, quantities with zero mean under independence—to construct correct p-values, meaning that the corresponding tests control their false positive (FP) rate. Thanks to this study, we introduce a method, named permutation UE, which consists of a multiple testing procedure based on permutation of experimental trials and delayed coincidence count. Each involved single test of this procedure achieves the prescribed level, so that the corresponding multiple testing procedure controls the false discovery rate (FDR), and this with as few assumptions as possible on the underneath distribution, except independence and identical distribution across trials. The mathematical meaning of this assumption is discussed, and it is in particular argued that it does not mean what is commonly referred in neuroscience to as cross-trials stationarity. Some simulations show, moreover, that permutation UE outperforms the trial-shuffling of Pipa and Grün ( 2003 ) and the MTGAUE method of Tuleau-Malot et al. ( 2014 ) in terms of single levels and FDR, for a comparable amount of false negatives. Application to real data is also provided.
Different continents, same species? Resolving the taxonomy of some Holarctic Ancylis Hübner (Lepidoptera: Tortricidae)
Authors: GILLIGAN TODD , HUEMER PETER , WIESMAIR BENJAMIN 
Published: October 2016

Several species of Ancylis related to A. unguicella (Linnaeus) and A. geminana (Donovan) have been presumed by previous authors to be Holarctic. However, difficulty in identifying genitalic characters to define and separate these taxa has brought into question their true distribution and led to inconsistencies in their taxonomic treatment in Europe and North America. Here we use a combination of DNA barcode sequence data and morphology to resolve these taxonomic differences, determine the actual geographic range of these taxa, and describe three new species. In the A. unguicella group, only A. unguicella and A. uncella (Denis & Schiffermüller) are Holarctic in distribution. In the A. geminana group, none of the taxa are Holarctic in their distribution. Three species are described as new: A. christiandiana Huemer and Wiesmair, sp.n. (Austria, Germany); A. oregonensis Gilligan and Huemer, sp.n. (USA: Oregon); and A. saliana Gilligan and Huemer, sp.n. (USA: Florida). In addition, Ancylis carbonana Heinrich, syn.n., is synonymized with A. uncella; A. cuspidana (Treitschke), syn.rev., is synonymized with A. diminutana (Haworth); and A. diminuatana Kearfott, stat.rev., and A. subarcuana (Douglas), stat.rev., are raised from synonymy.
Dependence of the Ice Water Content and Snowfall Rate on Temperature, Globally: Comparison of in Situ Observations, Satellite Active Remote Sensing Retrievals, and Global Climate Model Simulations
Authors: Heymsfield Andrew , Krämer Martina , Wood Norman B. , Gettelman Andrew , Field Paul R. , Liu Guosheng 
Published: October 2016

AbstractCloud ice microphysical properties measured or estimated from in situ aircraft observations are compared with global climate models and satellite active remote sensor retrievals. Two large datasets, with direct measurements of the ice water content (IWC) and encompassing data from polar to tropical regions, are combined to yield a large database of in situ measurements. The intention of this study is to identify strengths and weaknesses of the various methods used to derive ice cloud microphysical properties. The in situ data are measured with total water hygrometers, condensed water probes, and particle spectrometers. Data from polar, midlatitude, and tropical locations are included. The satellite data are retrieved from CloudSat/CALIPSO [the CloudSat Ice Cloud Property Product (2C-ICE) and 2C-SNOW-PROFILE] and Global Precipitation Measurement (GPM) Level2A. Although the 2C-ICE retrieval is for IWC, a method to use the IWC to get snowfall rates S is developed. The GPM retrievals are for snowfall rate only. Model results are derived using the Community Atmosphere Model (CAM5) and the Met Office Unified Model [Global Atmosphere 7 (GA7)]. The retrievals and model results are related to the in situ observations using temperature and are partitioned by geographical region. Specific variables compared between the in situ observations, models, and retrievals are the IWC and S. Satellite-retrieved IWCs are reasonably close in value to the in situ observations, whereas the models’ values are relatively low by comparison. Differences between the in situ IWCs and those from the other methods are compounded when S is considered, leading to model snowfall rates that are considerably lower than those derived from the in situ data. Anomalous trends with temperature are noted in some instances.
Regional Ensemble–Variational Data Assimilation Using Global Ensemble Forecasts
Authors: Wu Wan-Shu , Parrish David F. , Rogers Eric , Lin Ying 
Published: October 2016

Abstract
At the National Centers for Environmental Prediction, the global ensemble forecasts from the ensemble Kalman filter scheme in the Global Forecast System are applied in a regional three-dimensional (3D) and a four dimensional (4D) ensemble–variational (EnVar) data assimilation system. The application is a one-way variational method using hybrid static and ensemble error covariances. To enhance impact, three new features have been added to the existing EnVar system in the Gridpoint Statistical Interpolation (GSI). First, the constant coefficients that assign relative weight between the ensemble and static background error are now allowed to vary in the vertical. Second, a new formulation is introduced for the ensemble contribution to the analysis surface pressure. Finally, in order to make use of the information in the ensemble mean that is disregarded in the existing EnVar in GSI, the trajectory correction, a novel approach, is introduced. Relative to the application of a 3D variational data assimilation algorithm, a clear positive impact on 1–3-day forecasts is realized when applying 3DEnVar analyses in the North American Mesoscale Forecast System (NAM). The 3DEnVar DA system was operationally implemented in the NAM Data Assimilation System in August 2014. Application of a 4DEnVar algorithm is shown to further improve forecast accuracy relative to the 3DEnVar. The approach described in this paper effectively combines contributions from both the regional and the global forecast systems to produce the initial conditions for the regional NAM system.
False Vocal Fold Characteristics in Presbylarynges and Recurrent Laryngeal Neuropathy
Authors: Persky Michael , Sanders Brian , Rosen Clark A. , Kahane Joel , Fang Yixin , Amin Milan R. , Branski Ryan C. 
Published: October 2016

Objective: Conflicting data exist regarding false vocal fold (FVF) anatomy; it is unclear if this structure is an extension of the thyroarytenoid muscle or an independent muscle system. This confusion is amplified by diverse clinical findings in the setting of unilateral recurrent laryngeal neuropathy and presbylarynges. We sought to characterize FVF behavior in these contexts. Methods: Laryngoscopic/stroboscopic examinations from 11 patients with unilateral recurrent laryngeal nerve paresis and 12 patients with presbylarynges were reviewed by 4 laryngologists, blinded to the goal of the study but informed of diagnosis. Variables related to FVF structure and function at rest and during phonation were rated. Results: In recurrent laryngeal neuropathy, no significant association between atrophic/paretic vocal fold (VF) and FVF size was observed at rest ( P = .69). During phonation, FVF compression was noted bilaterally; contralateral FVF hypertrophy was more common ( P = .002). In presbylarynges, neither FVF size at rest ( P = .86) nor compression during phonation ( P = .37) was associated with the more atrophic VF; FVF compression/hypertrophy was common. Conclusions: Consistent with clinical dogma, FVF compression was more common contralateral to VF neuropathy. This finding, however, was inconsistent and may suggest individual variability in FVF innervation and/or morphology. Intra- and interrater reliability of these clinical findings was poor.
Benign Paroxysmal Positional Vertigo Secondary to Mild Head Trauma
Authors: Balatsouras Dimitrios G. , Koukoutsis George , Aspris Andreas , Fassolis Alexandros , Moukos Antonis , Economou Nicolas C. , Katotomichelakis Michael 
Published: October 2016

Objectives: We studied the clinical characteristics, nystagmographic findings, and treatment outcome of a group of patients with benign paroxysmal positional vertigo (BPPV) secondary to mild head trauma and compared them with a group of patients with idiopathic BPPV. Methods: The medical records of 33 patients with BPPV associated with mild head trauma were reviewed. Data of a complete otolaryngological, audiological, neurotologic, and imaging evaluation were available for all patients. Three hundred and twenty patients with idiopathic BPPV were used as a control group. Results: The patients with BPPV secondary to mild head trauma presented the following features, in which they differed from the patients with idiopathic BPPV: (1) lower mean age, with more intense symptoms; (2) increased rate of horizontal and anterior semicircular canal involvement and frequent multiple canal and bilateral involvement; (3) greater incidence of canal paresis and presence of spontaneous nystagmus; (4) poorer treatment results, attributed mainly to coexisting canal paresis in many patients, and higher rate of recurrence. Conclusions: Benign paroxysmal positional vertigo associated with mild head trauma differs from idiopathic BPPV in terms of several epidemiological and clinical features; it responds less effectively to treatment and is prone to recurrence.
Robust anticipative energy management system: Application of a smart building platform
Authors: Le Minh-Hoang , Ploix Stephane 
Published: October 2016

Robust energy management in buildings is addressed in this paper. The energetic impact of buildings in the current energetic context is first presented. Then the studied optimization problem is defined as the optimal management of production and consumption activities in buildings. A scheduling problem is identified to adjust the energy consumption to both the energy cost and the user’s comfort. The available flexibility of the services provided by domestic appliances is used to compute optimal energy plans. These flexibilities are associated to time windows or heating storage abilities. A constraints formulation of the energy allocation problem is given. A derived mixed linear program is used to solve this problem. The energy consumption in houses is very dependent on uncertain data such as weather forecasts and inhabitants’ activities. Parametric uncertainties are introduced in the home energy management problem in order to provide robust energy allocation. Robust linear programming is implemented. A scenario-based approach is implemented to face this robust optimization problem. Practical application: Because of the increasing part of renewable energy in electricity production, which is difficult to control, consumers will have to become more involved in the grid management. This paper states the problem of energy management in buildings and describes the optimization problem defined to adjust the energy consumption of buildings to production constraints. This decision system is based on the weather forecasts and a variable cost of electricity. Parametric uncertainties on the data are taken into account in order to propose robust energy planning in which a performance is guaranteed over the expected data.