bluuebunny/crossref_metadata_2025_split huggingface dataset:
Engineering Cell Surface Function with DNA Origami
Authors: Akbari Ehsan , Mollica Molly Y. , Lucas Christopher R. , Bushman Sarah M. , Patton Randy A. , Shahhosseini Melika , Song Jonathan W. , Castro Carlos E. 
Published: October 2017

AbstractA specific and reversible method is reported to engineer cell‐membrane function by embedding DNA‐origami nanodevices onto the cell surface. Robust membrane functionalization across epithelial, mesenchymal, and nonadherent immune cells is achieved with DNA nanoplatforms that enable functions including the construction of higher‐order DNA assemblies at the cell surface and programed cell–cell adhesion between homotypic and heterotypic cells via sequence‐specific DNA hybridization. It is anticipated that integration of DNA‐origami nanodevices can transform the cell membrane into an engineered material that can mimic, manipulate, and measure biophysical and biochemical function within the plasma membrane of living cells.
Semiconductive Materials with Tunable Electrical Resistance and Surface Polarity Obtained by Asymmetric Functionalization of Janus Nanoparticles
Authors: Mihali Voichita , Honciuc Andrei 
Published: October 2017

AbstractJanus nanoparticles (JNPs) can offer significant potential for synthesis of multifunctional materials, due to their inherent property contrast between the lobes. Asymmetric surface chemical modifications on JNPs can be performed such that each lobe can carry different surface and/or bulk‐like properties, which could be combined in surprising ways. In this work, it is shown that snowman‐type polymeric JNPs can be used to make conductive materials with tunable resistance and surface polarity. By changing the relative size between a conductive and an electrically insulating lobe, the bulk powder conductivity within a series of JNPs by a factor of 10 without changing the intrinsic conductivity of the polymer can be tuned. In the same time, the surface polarity of the powder material decreased by a factor of 5. The possibility to synthesize multifunctional materials from JNPs building blocks that enable the coupling of a bulk‐like property with a surface functionality is therefore demonstrated.
Palladium‐Catalyzed Ring‐Opening of 2‐Alkylidenecyclobutanols: Stereoselective Synthesis of γ,δ‐Unsaturated Ketones by C−C Bond Cleavage
Authors: Chen Ling , Sun Feng‐Na , Sun Yu‐Li , Xu Zheng , Zheng Zhan‐Jiang , Cui Yu‐Ming , Cao Jian , Xu Li‐Wen 
Published: October 2017

AbstractA facile synthesis of γ,δ‐unsaturated ketones via palladium‐catalyzed ring‐opening of 2‐alkylidenecyclobutanols with organic halides is described. The key step involves
−
bond cleavage via palladium‐catalyzed β‐carbon elimination. The desired γ,δ‐unsaturated ketones are obtained in good to excellent yields and broad functional group tolerability. Aryl, heteroaryl, benzyl, and alkynyl halides all readily participate to forge tri‐substituted carbon‐carbon double bond in a stereoselective manner.magnified image
Community Power Structure Analysis and the Ethical Considerations of “Studying Up”
Authors: Kivell Natalie M. , Evans Scotney D. , Paterson Susan E. 
Published: October 2017

AbstractThis narrative outlines our challenges in studying power and power structures within an individual‐level ethical framework. Taking a social ethics perspective, we share the story of our “sticky situation” (Campbell, ) that transpired during a multi‐year community partnership. We were asked, by our community partners, to help collect interview data without informed consent. As a team of community‐engaged university researchers, we were faced with a seemingly easy ethical situation (no consent, no research) that had unexpectedly complicated and long‐lasting consequences. This experience revealed to us how community‐engaged research and action, under a traditional ethics framework, can often work to protect those in positions of power and offer little to disrupt the status quo. Reflecting on the tension between individual and social ethics, we discuss the limitations of an individual‐level framework, including the definitions for respect for persons, justice, and beneficence, on our ability as a field to understand, critique, and contribute to the dismantling of oppressive power structures.
Reflexivity in Counterspaces Fieldwork
Authors: Case Andrew D. 
Published: October 2017

AbstractReflexivity is an important tool for navigating ethically important moments in fieldwork. It may be particularly useful in situations where the researcher has the potential to undermine the conduct of the study and/or the well‐being‐enhancing role of counterspaces. In this article, I explore my use of reflexivity to traverse ethically important moments I encountered while investigating a counterspace for African‐American youth who had been incarcerated. The ethical challenge concerned whether and how to continue this study in light of realizing that I held implicit biases toward the research participants. I describe my process for arriving at a decision and propose key considerations for the use of reflexivity in supporting ethical fieldwork within counterspaces.
Prognostic significance of additional chromosomal abnormalities at the time of diagnosis in patients with chronic myeloid leukemia treated with frontline tyrosine kinase inhibitors
Authors: Alhuraiji Ahmad , Kantarjian Hagop , Boddu Prajwal , Ravandi Farhad , Borthakur Gautam , DiNardo Courtney , Daver Naval , Kadia Tapan , Pemmaraju Naveen , Pierce Sherry , Garcia‐Manero Guillermo , Wierda William , Verstovsek Srdan , Jabbour Elias , Cortes Jorge 
Published: October 2017

AbstractAdditional cytogenetic abnormalities (ACA) are considered a high risk feature in chronic myeloid leukemia (CML). However, its prognostic significance at the time of diagnosis in the setting of new tyrosine kinase inhibitors (TKIs) is less well understood. Patients with CML in CP with or without ACA at diagnosis treated with frontline TKIs in prospective clinical trials were analyzed for outcomes. Among 603 patients treated, 29 (5%) had ACA. Patients with ACA included 2 of 72 (2.8%) treated with imatinib 400 mg, 9 of 207 (4.3%) with imatinib 800 mg, 10 of 148 (6.7%) with dasatinib, 6 of 126 (4.7%) with nilotinib, and 2 of 50 (4%) with ponatinib. There was a significantly higher rate of complete cytogenetic response (CCyR) at 6 months in patients without ACA (P = .02). However cumulative CCyR and major molecular response (MMR) rates were not different. Similarly, MR4.0 and MR4.5 rates were similar for both groups; two CML‐ACA patients maintained MR 4.5 for at least 2 years. At 5 years, ACA at diagnosis did not significantly impact transformation‐free, failure‐free, event‐free, or overall survival expectations. Acknowledging small sample size estimates, response rates and survival outcomes were comparable in CP with ACA irrespective of whether chromosomal abnormalities were “major route” or other. The presence of ACA at diagnosis does not confer worse prognosis for patients with CML treated with TKI. Thus, the presence of ACA at diagnosis should not alter treatment strategies in these patients.
DNA methylation of methylation complex genes in relation to stress and genome‐wide methylation in mother–newborn dyads
Authors: Clukay Christopher J. , Hughes David A. , Rodney Nicole C. , Kertes Darlene A. , Mulligan Connie J. 
Published: October 2017

AbstractObjectivesEarly life stress is known to have enduring biological effects, particularly with respect to health. Epigenetic modifications, such as DNA methylation, are a possible mechanism to mediate the biological effect of stress. We previously found correlations between maternal stress, newborn birthweight, and genome‐wide measures of DNA methylation. Here we investigate ten genes related to the methylation/demethylation complex in order to better understand the impact of stress on health.Materials and methodsDNA methylation and genetic variants at methylation/demethylation genes were assayed. Mean methylation measures were constructed for each gene and tested, in addition to genetic variants, for association with maternal stress measures based on interview and survey data (chronic stress and war trauma), maternal venous, and newborn cord genome‐wide mean methylation (GMM), and birthweight.ResultsAfter cell type correction, we found multiple pairwise associations between war trauma, maternal GMM, maternal methylation at DNMT1, DNMT3A, TET3, and MBD2, and birthweight.ConclusionsThe association of maternal GMM and maternal methylation at DNMT1, DNMT3A, TET3, and MBD2 is consistent with the role of these genes in establishing, maintaining and altering genome‐wide methylation patterns, in some cases in response to stress. DNMT1 produces one of the primary enzymes that reproduces methylation patterns during DNA replication. DNMT3A and TET3 have been implicated in genome‐wide hypomethylation in response to glucocorticoid hormones. Although we cannot determine the directionality of the genic and genome‐wide changes in methylation, our results suggest that altered methylation of specific methylation genes may be part of the molecular mechanism underlying the human biological response to stress.
A validated model for the 22‐item Sino‐Nasal Outcome Test subdomain structure in chronic rhinosinusitis
Authors: Feng Allen L. , Wesely Nicholas C. , Hoehle Lloyd P. , Phillips Katie M. , Yamasaki Alisa , Campbell Adam P. , Gregorio Luciano L. , Killeen Thomas E. , Caradonna David S. , Meier Josh C. , Gray Stacey T. , Sedaghat Ahmad R. 
Published: October 2017

BackgroundPrevious studies have identified subdomains of the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), reflecting distinct and largely independent categories of chronic rhinosinusitis (CRS) symptoms. However, no study has validated the subdomain structure of the SNOT‐22. This study aims to validate the existence of underlying symptom subdomains of the SNOT‐22 using confirmatory factor analysis (CFA) and to develop a subdomain model that practitioners and researchers can use to describe CRS symptomatology.MethodsA total of 800 patients with CRS were included into this cross‐sectional study (400 CRS patients from Boston, MA, and 400 CRS patients from Reno, NV). Their SNOT‐22 responses were analyzed using exploratory factor analysis (EFA) to determine the number of symptom subdomains. A CFA was performed to develop a validated measurement model for the underlying SNOT‐22 subdomains along with various tests of validity and goodness of fit.ResultsEFA demonstrated 4 distinct factors reflecting: sleep, nasal, otologic/facial pain, and emotional symptoms (Cronbach's alpha, >0.7; Bartlett's test of sphericity, p < 0.001; Kaiser‐Meyer‐Olkin >0.90), independent of geographic locale. The corresponding CFA measurement model demonstrated excellent measures of fit (root mean square error of approximation, <0.06; standardized root mean square residual, <0.08; comparative fit index, >0.95; Tucker‐Lewis index, >0.95) and measures of construct validity (heterotrait‐monotrait [HTMT] ratio, <0.85; composite reliability, >0.7), again independent of geographic locale.ConclusionThe use of the 4‐subdomain structure for SNOT‐22 (reflecting sleep, nasal, otologic/facial pain, and emotional symptoms of CRS) was validated as the most appropriate to calculate SNOT‐22 subdomain scores for patients from different geographic regions using CFA.
Improving Shortcuts to Non‐Hermitian Adiabaticity for Fast Population Transfer in Open Quantum Systems
Authors: Chen Ye‐Hong , Wu Qi‐Cheng , Huang Bi‐Hua , Song Jie , Xia Yan , Zheng Shi‐Biao 
Published: October 2017

AbstractIt is still a challenge to experimentally realize shortcuts to adiabaticity (STA) for a non‐Hermitian quantum system since a non‐Hermitian quantum system's counterdiabatic driving Hamiltonian contains some unrealizable auxiliary control fields. In this paper, we relax the strict condition in constructing STA and propose a method to redesign a realizable supplementary Hamiltonian to construct non‐Hermitian STA. The redesigned supplementary Hamiltonian can be eithersymmetric or asymmetric. For the sake of clearness, we apply this method to an Allen‐Eberly model as an example to verify the validity of the optimized non‐Hermitian STA. The numerical simulation demonstrates that a ultrafast population inversion could be realized in a two‐level non‐Hermitian system.
Tough thiourethane thermoplastics for fused filament fabrication
Authors: Ellson Gregory , Carrier Xavier , Walton Jamie , Mahmood Samsuddin Faisal , Yang Kejia , Salazar Joshua , Voit Walter E. 
Published: October 2017

ABSTRACTFused filament fabrication (FFF) is the most common form of additive manufacturing. Most FFF materials are variants of commercially available engineering plastics. Their performance when printed can widely vary, thus there is an increasing volume of research on alternative materials with thermal and mechanical performance optimized for FFF. In this work, thiol–isocyanate polymerization is used for the development of a one‐pot synthesis for polythiourethane thermoplastics for tough three‐dimensional (3D) printing applications. The thiol–isocyanate reaction mechanism allows for rapid polymer synthesis with minimal byproduct formation and few limitations on reaction conditions. The resulting elastomer has high toughness and a low melting point, making it favorable for use as a 3D printing filament. The elastomer outperforms commercial filaments in tension when printed. Considering the rapid advancement of additive manufacturing and the limitations of many engineering polymers with the 3D printing process, these results are encouraging for the development of bespoke 3D printing thermoplastics. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45574.
Linear viscoelasticity, extensional viscosity, and oxygen permeability of nanocomposites based on propylene copolymer and organoclay
Authors: Riechert Verónica , Quinzani Lidia M. , Failla Marcelo D. 
Published: October 2017

ABSTRACTRandom propylene‐terpolymer (PEBC)/organophilic montmorillonite nanocomposites were prepared by melt mixing, using PEBC modified with maleic anhydride (PEBCg) as compatibilizer. Clay concentrations up to 8 wt %, compatibilizer/clay ratios up to 3:1 and concentrations of anhydride groups (AG) in PEBCg of 0.4 and 0.6 wt % were considered. The degree of exfoliation of the clay increases with PEBCg content and its concentration of AGs. The dynamic moduli allow estimating the percolation threshold of the nanofiller at 5.4 wt %, which yields an average of 11 silicate layers per tactoid at percolation, in agreement with the minimum thickness estimated from XRD data. The presence of exfoliated clay gives place to strain hardening and softening, depending on clay concentration and magnitude of the Hencky strain. The amount of exfoliated clay, however, plays a minor role in front of the content of AGs of the compatibilizer in regard with the oxygen permeability of the polymer. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45840.
Adsorption capability of heavy metals by chitosan/poly(ethylene oxide)/activated carbon electrospun nanofibrous membrane
Authors: Shariful M. I. , Sepehr T. , Mehrali M. , Ang B. C. , Amalina M. A. 
Published: October 2017

ABSTRACTIn this study, activated carbon (AC) was synthesized by chemical activation process from rice husk, with the BET surface area of 2180 m2/g. Chitosan/poly(ethylene oxide) (PEO)/AC nanofibrous membrane (CPANM) was synthesized by electrospinning process. The average fiber diameter was found to be 83 ± 12.5 nm. Incorporation of AC lead to increase in the surface area of CPANM than chitosan/PEO fiber (CPF) by 371 m2/g. X‐ray photoelectron spectroscopy survey and narrow scan analysis further proved the presence of AC in the membrane. CPANM showed higher adsorption capability than CPF. Analysis of the mechanism of heavy metals adsorption by CPANM and CPF hypothesized that, (NH2) is the only active group in CPF, whereas both (NH2) and (COOH) contributed in adsorption for CPANM. Maximum adsorption capacity of CPANM for Cr(VI), Fe(III), Cu(II), Zn(II), and Pb(II) ion was found to be 261.1, 217.4, 195.3, 186.2, and 176.9 mg g−1 respectively. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45851.
The worth of giants: The consumptive and non‐consumptive use value of the giant sea bass (Stereolepis gigas)
Authors: Guerra Ana Sofía , Madigan Daniel J. , Love Milton S. , McCauley Douglas J. 
Published: October 2017

Abstract

Although the economic value of wildlife historically has been attributed to its consumptive use, the global growth of ecotourism has expanded wildlife valuation to include non‐consumptive uses. In California, the critically endangered giant sea bass (Stereolepis gigas) is paradoxically both a flagship species in the recreational dive industry and regularly sold in California's commercial fisheries when incidentally caught. The differences in the economic value of S. gigas to these two key stakeholders – commercial fishers and recreational scuba divers – were explored.
The average annual landing value of S. gigas was US$12 600, this value was determined using California commercial fishery landing receipt data. In contrast the estimated average value of S. gigas to recreational divers was US$2.3 million per year. The non‐consumptive use value was calculated by approximating the annual number of recreational charter boat divers and determining divers' willingness‐to‐pay for a S. gigas sighting.
Stated landings volumes of S. gigas appear to represent a minimum annual extraction of 2% to 19% of the S. gigas population. Using self‐reported fishery catch location data, S. gigas bycatch hotspots were identified and used to inform suggestions for strategic spatial and temporal closures.
Overall, these results highlight the value of giant sea bass beyond fisheries and underscore the importance of incorporating non‐consumptive values when developing harvest policies and marine management plans.
Temporal trends in percutaneous coronary interventions thru the drug eluting stent era: Insights from 18,641 procedures performed over 12‐year period
Authors: Landes Uri , Bental Tamir , Levi Amos , Assali Abid , Vaknin‐Assa Hana , Lev Eli I. , Rechavia Eldad , Greenberg Gabriel , Orvin Katia , Kornowski Ran 
Published: October 2017

AbstractBackgroundThe last decade, regarded as the DES era in PCI, has witnessed significant advances in the management of coronary disease. We aimed to assess temporal trends in the practice and outcome of percutaneous coronary intervention (PCI) during the drug eluting stent (DES) era.MethodsWe analyzed 18,641 consecutive PCI's performed between January 2004 and December 2016, distinguished by procedural date (Q1: 2004–2006, n = 4,865; Q2: 2007–2009, n = 4,977; Q3: 2010–2012, n = 4,230; Q4: 2013–2016, n = 4,569).ResultsAt presentation, mean patients age was 65 (±11) years and 22.8% were females. Over time, there was a rise in the relative number of octogenarians (Q1: 10.7% vs Q4: 15.5%, P < 0.001) and an increase in the burden of most comorbidities (e.g., left ventricular dysfunction ≥ moderate and chronic kidney disease, P < 0.001 for both). Despite a 2‐fold increase in the rate of complex interventions, and a 3‐fold increase in the rate of unprotected left‐main angioplasty (P < 0.001 for both), the radial approach was increasingly adopted (Q1: 2% to Q4: 63.5%, P < 0.001). DES implantation increased from 43% to 83% at the expense of bare metal stent (BMS) application, and accompanied by drug coated balloon sprout to 1.8%, P < 0.001. Kaplan–Meier survival curves revealed a time‐based enhanced outcome, with a decreased rate of death, MI, target vessel revascularization and CABG over the years.ConclusionsIn the last decade, PCI has evolved to offer better outcome to more elderly, sicker patient population, with more complex coronary disease interventions. The shift to second generation DES and to enhanced PCI techniques may explain part of this progress.
Cytotoxicity of Group 5 Transition Metal Ditellurides (MTe2; M=V, Nb, Ta)
Authors: Chia Hui Ling , Latiff Naziah Mohamad , Sofer Zdenĕk , Pumera Martin 
Published: October 2017

AbstractMuch research effort has been put in to study layered compounds with transition metal dichalcogenides (TMDs) being one of the most studied compounds. Due to their extraordinary properties such as excellent electrochemical properties, tuneable band gaps, and low shear resistance due to weak van der Waals interactions between layers, TMDs have been found to have wide applications such as electrocatalysts for hydrogen evolution reactions, supercapacitors, biosensors, field‐effect transistors (FETs), photovoltaics, and lubricant additives. In very recent years, Group 5 transition metal ditellurides have received an immense amount of research attention. However to date, little has been known of the potential toxicities posed by these materials. As such, we conducted the cytotoxicity study by incubating various concentrations of the Group 5 transition metal ditellurides (MTe2; M=V, Nb, Ta) with human lung carcinoma epithelial A549 cells for 24 hours and the remaining cell viabilities after treatment was measured. Our findings indicate that VTe2 is highly toxic whereas NbTe2 and TaTe2 are deemed to exhibit mild toxicities. This study constitutes an exemplary first step towards the understanding of the Group 5 transition metal ditellurides’ toxicity effects in preparation for their possible future commercialisation.
Ferromagnetism and Half‐Metallicity in a High‐Band‐Gap Hexagonal Boron Nitride System
Authors: Choudhuri Indrani , Pathak Biswarup 
Published: October 2017

AbstractMetal‐free half‐metallicity is the subject of intense research in the field of spintronics devices. Using density functional theoretical calculations, atom‐thin hexagonal boron nitride (h‐BN)‐based systems are studied for possible spintronics applications. Ferromagnetism is observed in patterned C‐doped h‐BN systems. Interestingly, such a patterned C‐doped h‐BN exhibits half‐metallicity with a Curie temperature of approximately 324 K at a particular C‐doping concentration. It shows half‐metallicity more than metal‐free systems studied to date. Thus, such a BN‐based system can be used to achieve a 100 % spin‐polarised current at the Fermi level. Furthermore, this C‐doped system shows excellent dynamical, thermal, and mechanical properties. Therefore, a stable metal‐free planar ferromagnetic half‐metallic h‐BN‐based system is proposed for use in room‐temperature spintronics devices.
On‐Surface Synthesis of Adenine Oligomers via Ullmann Reaction
Authors: Zhang Yanmin , Ding Yuanqi , Xie Lei , Ma Honghong , Yao Xinyi , Zhang Chi , Yuan Chunxue , Xu Wei 
Published: October 2017

AbstractDespite the fact that DNA bases have been well‐studied on surface, the on‐surface synthesis of one‐dimensional DNA analogs through in situ reactions is still an interesting topic to be investigated. Herein, from the interplay of high‐resolution scanning tunneling microscopy (STM) imaging and density functional theory (DFT) calculations, we have delicately designed a halogenated derivative of adenine as precursor to realize the combination of DNA bases and Ullmann reaction, and then successfully synthesized adenine oligomers on Au(111) via Ullmann coupling. This model system provides a possible bottom‐up strategy of fabricating adenine oligomers on surface, which may further give access to man‐made DNA strands with multiple bases.