bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimization of greenhouse gas valorization over ceria‐promoted Co–Ni/graphene oxide catalytic materials using response surface methodology
Authors: Mageed Alyaa K. , Alsaffar May Ali , Abdel Ghany Mohamed Abdel Rahman , Sukkar Khalid A. , Ayodele Bamidele Victor 
Published: September 2024

AbstractBackgroundThe mitigation of global warming effect requires intensified research efforts to reduce greenhouse gas emissions. This study was aimed at investigating the valorization of two principal greenhouse gases, namely carbon dioxide (CO2) and methane (CH4), over CeO2‐doped Co–Ni/GO catalytic materials. The CeO2‐doped Co–Ni/GO catalysts were synthesized using a sequential wet impregnation method and employed for CO2 reforming of CH4. The catalytic materials were characterized using various instrumental techniques. Response surface methodology (RSM) was employed to investigate the impact of process factors, namely reaction temperature (ranging from 700 to 800 °C), CeO2 loading (ranging from 5% to 15%) and feed flowrate (ranging from 10n to 50 mL min−1), on the CH4 conversions.ResultsThe three factors were observed to have significant influence on the CH4 conversion based on analysis of variance. The analysis of the RSM quadratic model revealed that the optimum conditions of 800 °C, 14.22% and 10.00 mL min−1 were obtained for the reaction temperature, CeO2 loading and feed flowrate resulting in maximum CH4 conversion of 98.24%. The desirability function for these results was calculated to be 0.934. The predicted process parameters aligned with the results of the actual experimental analysis.ConclusionThis study has demonstrated that the conversion of CH4 to value‐added products such as syngas can be optimized using RSM. The optimum conditions obtained could be used to improve the process performance. © 2024 Society of Chemical Industry (SCI).
Evaluation of developmental milestones and of brain measurements in rats exposed to the pesticide pyriproxyfen in prenatal period
Authors: Pereira Katriane Endiel , de Aguiar Gabrielle Batista , Villanova Bianca , Rabello Nicole Jansen , Schelbauer Rafaela , Carniel Estela Soares , Moresco Rafaela Maria , de Souza Marcelo Alves , Centenaro Lígia Aline 
Published: September 2024

AbstractPyriproxyfen is a pesticide used in Brazil to control the Aedes aegypti mosquito, vector of arboviruses like Zika and dengue. However, this pesticide is structurally similar to retinoic acid, a metabolite of vitamin A that regulates neuronal differentiation and hindbrain development during the embryonic period. Due to the similarity between pyriproxyfen and retinoic acid, studies indicate that this pesticide may have cross‐reactivity with retinoid receptors. Thus, pregnant exposure to pyriproxyfen could interfere in the nervous system development of the fetal. In this context, the present study evaluated whether prenatal exposure to pyriproxyfen affects neonatal development and brain structure in rats. Wistar rat pups were divided in three experimental groups: (1) negative control (CT−)—offspring of rats that drink potable water during pregnancy; (2) pyriproxyfen (PIR)—offspring of rats exposed to Sumilarv® prenatally, a pesticide that has pyriproxyfen as active ingredient; and (3) positive control (CT+)—offspring of rats exposed to an excess of vitamin A prenatally. Only vitamin A treated‐pregnant showed lower weight gain, but gestation length was similar among pregnant that received potable water, water containing vitamin A and water containing Sumilarv. In relation to the offspring, PIR group exhibits a delayed front‐limb suspension response but performed early the negative geotaxis reflex. On the other hand, CT+ group exhibited lower body weight in the 1st postnatal day, delayed audio startle response, but performed early the eyelids opening and hindlimb placing response. A reduction in the maximum brain width was observed both in PIR and CT+ groups, but a reduction in the number of neurons in the M1 cortex was showed only in CT+ group. The number of glial cells in this brain area was similar between the three experimental groups studied. Although prenatal exposure to pyriproxyfen did not alter neonatal milestones in the same way as vitamin A in excess, both substances caused a reduction in the maximum width of the brain, suggesting that this pesticide can produce neurotoxic effects during the embryonic period.
The emergence of parvovirus B19 as a pathogen in acute encephalitis syndrome
Authors: Dey Sayantika , Mohanty Monalisa , Mamidi Prabhudutta , Naik Suprava , Gupta Kavita , Dwibedi Bhagirathi , Devi Sujata , Mahapatra Ashoka , Das Rashmi Ranjan , Behera Bijayini , Bhoi Sanjeev Kumar , Mishra Baijayantimala 
Published: September 2024

AbstractDespite scarcity of data, in recent years, human parvovirus B19 (PVB19) has been emerging as an important pathogen in acute encephalitis syndrome (AES). But, PVB19 virus is mostly looked for only after the exclusion of other common pathogens implicated in AES. Hence, this study was conducted to correlate clinical, radiological, and sequencing data to establish the crucial role of PVB19 in AES. Cerebrospinal fluid and/or serum samples were collected from AES patients as per WHO criteria and tested by ELISA, real‐time PCR and bacterial culture sensitivity for various pathogens. PVB19 positive samples were subjected to sequencing. PVB19 attributed to 5% of total AES cases in the present study with fatalities in two of eight cases. Two isolates of PVB19 belonged to Genotype 1 A whereas one belonged to Genotype 3B. On multivariate analysis of predictive symptoms of PVB19 AES cases, blurring of vision (odds ratio [OR] 20.67; p = 0.001) was found to be significant independent predictor of PVB19 AES. Six of eight patients (two encephalitis specific and four nonspecific) had abnormal radiological findings. Hence, being an emerging viral pathogen, PVB19 should be included in the diagnostic algorithm of AES for prompt diagnosis and definitive management to prevent undesired neurological sequelae.
Electro‐anatomically confirmed sites of origin of ventricular tachycardia and premature ventricular contractions and occurrence of R wave in lead aVR: A proof of concept study
Authors: Abedin Zainul , Smith Seth , Kattamuri Lakshmi , Melendez Amy , Abedin Moeen 
Published: September 2024

AbstractBackgroundThe R wave in lead aVR, during the wide QRS complex tachycardia, is commonly observed in a ventricular tachycardia (VT) arising from certain locations in the ventricles.ObjectivesThis was a retrospective and a proof of concept study to correlate the sites of origin of VT and premature ventricular contractions (PVCs) with the occurrence of R wave in lead aVR.MethodsPatients with VT or high density of PVCs were included. Surface and intracardiac electrograms were recorded during the arrhythmia. VTs and PVCs arising from the inferior, inferolateral, or apical region of the ventricles were grouped into Zone 2. Those arising from the other areas of the ventricles were grouped into Zone 1.ResultsSixty‐four patients were included in the study. The mean age was 57 years. There were 47 males. Among 64 patients with VT or PVCs, 28 patients had an R wave in aVR (43.7%), In 26 of 28 patients with an R wave in aVR, the site of origin of the arrhythmia was in Zone 2. The R wave in aVR was absent in 36 patients, 34 of whom had the origin of arrhythmia focus in Zone 1. The presence of an R wave in aVR correctly identified Zone 2 as a site of origin of the arrhythmia with high sensitivity (93%) and specificity (94%).ConclusionsThe presence of an R wave in aVR during wide QRS complex tachycardia or PVC is a valuable observation for identifying the site of origin of the arrhythmia and hence in distinguishing supraventricular tachycardia with aberrancy from VT.
Genetic Adaptations and Mechanistic Insights Into Bacterial Bioremediation in Ecosystems
Authors: Vinayagam Yamini , Rajeswari Vijayarangan Devi 
Published: September 2024

ABSTRACTMetal pollution poses significant threats to the ecosystem and human health, demanding effective remediation strategies. Bioremediation, which leverages the unique metal‐resistant genes found in bacteria, offers a cost‐effective and efficient solution to heavy metal contamination. Genes such as Cad, Chr, Cop, and others provide pathways to improve the detoxification of the ecosystem. Through multiple techniques, genetic engineering makes bacterial genomes more capable of improving metal detoxification; nonetheless, there are still unanswered questions regarding the nature of new metal‐resistant genes. This article examines bacteria's complex processes to detoxify toxic metals, including biosorption, bioaccumulation, bio‐precipitation, and bioleaching. It also explores essential genes, proteins, signaling mechanisms, and bacterial biomarkers involved in breaking toxic metals.
Force training neural network potential energy surface models
Authors: Devereux Christian , Yang Yoona , Martí Carles , Zádor Judit , Eldred Michael S. , Najm Habib N. 
Published: September 2024

AbstractMachine learned chemical potentials have shown great promise as alternatives to conventional computational chemistry methods to represent the potential energy of a given atomic or molecular system as a function of its geometry. However, such potentials are only as good as the data they are trained on, and building a comprehensive training set can be a costly process. Therefore, it is important to extract as much information from training data as possible without further increasing the computational cost. One way to accomplish this is by training on molecular forces in addition to energies. This allows for three additional labels per atom within the molecule. Here we develop a neural network potential energy surface for studying a hydrogen transfer reaction between two isomers of . We show that, for a much smaller training set, force training not only improves the accuracy of the model compared to only training on energies, but also provides more accurate and smoother first and second derivatives that are crucial to run dynamics and extract vibrational frequencies in the context of transition‐state theory. We also demonstrate the importance of choosing the proper force to energy weight ratio for the loss function to minimize the model test error.
Stimulation conditions leading to electrical vestibular co‐stimulation in cochlear implant users
Authors: Fröhlich Laura , Plontke Stefan K. , Löffler Lea B. , Manthey Antonia , Rahne Torsten 
Published: September 2024

AbstractObjectivesThe study objective was to investigate the influence of electrical stimulus properties on cervical and ocular vestibular‐evoked myogenic potentials to electrical stimulation by cochlear implants (e‐cVEMPs, e‐oVEMPs).MethodsE‐VEMPs were recorded in adult Nucleus cochlear implant (CI) patients using electric pulse trains (4 biphasic pulses at 1000 Hz burst rate). Ground path and stimulation electrodes were varied between monopolar stimulation at basal electrode contact E3 (MP1 + 2 E3), monopolar stimulation at apical electrode contact E20 (MP1 + 2 E20), and bipolar transmodiolar stimulation between E3 and E14 (BP E3‐E14). The electric pulse train was further varied to 2 pulses at 1000 Hz, 2 pulses at 500 Hz, and a single pulse, in patients with present e‐VEMP responses. VEMPs to bone‐conducted vibration (BCV) were recorded as reference in all participants.ResultsMeasurements were conducted in 30 ears of 27 participants (mean age 49.3 years, SD 12.7 years). E‐VEMPs were present in 13 ears (43%). 5 of the 13 cases showed e‐VEMPs but no BCV evoked VEMPs. Response numbers increased with increasing stimulation levels. The highest response rate of 40% was obtained for MP1 + 2 E3 stimulation. Stimulus variation did not affect response numbers. E‐VEMP amplitudes were comparable to BCV‐stimulated VEMPs. Latencies were up to 3.1 ms shorter for electric stimulation. Some patients showed e‐VEMP thresholds close to or below the electric hearing threshold level.ConclusionThe occurrence of e‐VEMPs is dependent on current path and stimulation level. Vestibular co‐stimulation by the CI is more likely in patients with high stimulation levels and for monopolar stimulation of basal electrode contacts.Level of Evidence4.
Prevalence of self‐reported voice and swallowing complaints in an outpatient geriatric population
Authors: Gascon Laurence , Belfiglio Mario , Nowacki Amy S. , Adessa Michelle , Hashmi Ardeshir Z. , Bryson Paul C. 
Published: September 2024

AbstractBackgroundOlder adults suffer from increased rates of dysphagia and dysphonia, both of which have a profound effect on quality of life and are often underdiagnosed. We sought to better understand the prevalence of these complaints and the potential utility of a patient‐reported screening program in a geriatrics clinic.MethodsUsing an IRB‐approved cross‐sectional survey and retrospective cohort design, we recruited participants from a population of new patients seeking care at an academic geriatrics clinic. We used three validated questionnaires to assess self‐reported dysphagia, dysphonia, and pill dysphagia: the Eating‐Assessment Tool‐10 (EAT‐10), the Voice Handicap Index‐10 (VHI‐10), and the PILL‐5. Patients who screened positive on any questionnaire were offered referral to a laryngologist for additional evaluation. Patients who screened positive on the PILL‐5 were also offered referral to our geriatric pharmacist.ResultsAmong our 300 patients surveyed, the mean age was 76 (SD 8.46). A total of 82 (27.3%) patients screened positive (73 on EAT‐10, 10 on PILL‐5, 13 on VHI‐10) and were offered referral, of which 36 accepted. These positive screening patients took more prescription medications (p = .024) and had a higher GDS score (p < .001) when compared to the patients who screened negative.ConclusionsMany new patients seeking generalized care at our center screened positively for dysphagia and/or dysphonia on validated questionnaires. Geriatric patients may benefit from integrating screening for these disorders to identify the need of further evaluation. It is unknown if these survey tools are appropriate in a non‐otolaryngology clinic.Level of evidenceIII.
Characteristics of intestinal flora in nonobese nonalcoholic fatty liver disease patients and the impact of ursodeoxycholic acid treatment on these features
Authors: Wang Liyan , Xu Jiali , You Ningning , Shao Li , Zhuang Zhenjie , Zhuo Lili , Liu Jing , Shi Junping 
Published: September 2024

AbstractThe study aimed to investigate the alterations in gut microbiota among nonobese individuals with nonalcoholic fatty liver disease (NAFLD) and their response to treatment with ursodeoxycholic acid (UDCA). A total of 90 patients diagnosed with NAFLD and 36 healthy subjects were recruited to participate in this study. Among them, a subgroup of 14 nonobese nonalcoholic steatohepatitis (NASH) were treated with UDCA. Demographic and serologic data were collected for all participants, while stool samples were obtained for fecal microbiome analysis using 16S sequencing. In nonobese NAFLD patients, the alpha diversity of intestinal flora decreased (Shannon index, p < 0.05), and the composition of intestinal flora changed (beta diversity, p < 0.05). The abundance of 20 genera, including Fusobacterium, Lachnoclostridium, Klebsiella, etc., exhibited significant changes (p < 0.05). Among them, nine species including Fusobacterium, Lachnoclostridium, Klebsiella, etc. were found to be associated with abnormal liver enzymes and glucolipid metabolic disorders. Among the 14 NASH patients treated with UDCA, improvements were observed in terms of liver enzymes, CAP values, and E values (p < 0.05), however, no improve the glucolipid metabolism. While the alpha diversity of intestinal flora did not show significant changes after UDCA treatment, there was a notable alteration in the composition of intestinal flora (beta diversity, p < 0.05). Furthermore, UCDA treatment led to an improvement in the relative abundance of Alistipes, Holdemanella, Gilisia, etc. among nonobese NASH patients (p < 0.05). Nonobese NAFLD patients exhibit dysbiosis of the intestinal microbiota. UDCA can ameliorate hepatic enzyme abnormalities and reduce liver fat content in nonobese NASH patients, potentially through its ability to restore intestinal microbiota balance.
Efficient Spectral Broadening and Few‐Cycle Pulse Generation with Multiple Thin Liquid Films
Authors: Huang Jiacheng , Lu Xiang , Hu Feilong , Deng Yu , Long Jie , Tang Jiajun , He Lixin , Zhang Qingbin , Lan Pengfei , Lu Peixiang 
Published: September 2024

AbstractHigh‐energy, few‐cycle laser pulses are essential for numerous applications in the fields of ultrafast optics and strong‐field physics, due to their ultrafast temporal resolution and high peak intensity. In this work, different from the traditional hollow‐core fibers and multiple thin solid plates, the generation of an octave‐spanning supercontinuum broadening is demonstrated by utilizing multiple ultrathin liquid films (MTLFs) as the nonlinear media. The continuum covers a range from 380 to 1050 nm, corresponding to a Fourier transform limit pulse width of 2.5 fs when 35 fs Ti: sapphire laser pulse is applied on the MTLFs. The output pulses are compressed to 3.9 fs by employing chirped mirrors. Furthermore, a continuous high‐order harmonic spectrum up to the 33rd order is realized by subjecting the compressed laser pulses to interact with Kr gas. The utilization of flowing liquid films eliminates permanent optical damage and enables wider and stronger spectrum broadening. Therefore, this MTLFs scheme provides new solutions for the generation of highly efficient supercontinuum and nonlinear pulse compression, with potential applications in the fields of strong‐field physics and attosecond science.
Role of N6‐methyladenosine RNA modification in cancer
Authors: Qu Yi , Gao Nannan , Zhang Shengwei , Gao Limin , He Bing , Wang Chao , Gong Chunli , Shi Qiuyue , Li Zhibin , Yang Shiming , Xiao Yufeng 
Published: September 2024

AbstractN6‐methyladenosine (m6A) is the most abundant modification of RNA in eukaryotic cells. Previous studies have shown that m6A is pivotal in diverse diseases especially cancer. m6A corelates with the initiation, progression, resistance, invasion, and metastasis of cancer. However, despite these insights, a comprehensive understanding of its specific roles and mechanisms within the complex landscape of cancer is still elusive. This review begins by outlining the key regulatory proteins of m6A modification and their posttranslational modifications (PTMs), as well as the role in chromatin accessibility and transcriptional activity within cancer cells. Additionally, it highlights that m6A modifications impact cancer progression by modulating programmed cell death mechanisms and affecting the tumor microenvironment through various cancer‐associated immune cells. Furthermore, the review discusses how microorganisms can induce enduring epigenetic changes and oncogenic effect in microorganism‐associated cancers by altering m6A modifications. Last, it delves into the role of m6A modification in cancer immunotherapy, encompassing RNA therapy, immune checkpoint blockade, cytokine therapy, adoptive cell transfer therapy, and direct targeting of m6A regulators. Overall, this review clarifies the multifaceted role of m6A modification in cancer and explores targeted therapies aimed at manipulating m6A modification, aiming to advance cancer research and improve patient outcomes.
Radiogenomics: bridging the gap between imaging and genomics for precision oncology
Authors: He Wenle , Huang Wenhui , Zhang Lu , Wu Xuewei , Zhang Shuixing , Zhang Bin 
Published: September 2024

AbstractGenomics allows the tracing of origin and evolution of cancer at molecular scale and underpin modern cancer diagnosis and treatment systems. Yet, molecular biomarker‐guided clinical decision‐making encounters major challenges in the realm of individualized medicine, consisting of the invasiveness of procedures and the sampling errors due to high tumor heterogeneity. By contrast, medical imaging enables noninvasive and global characterization of tumors at a low cost. In recent years, radiomics has overcomes the limitations of human visual evaluation by high‐throughput quantitative analysis, enabling the comprehensive utilization of the vast amount of information underlying radiological images. The cross‐scale integration of radiomics and genomics (hereafter radiogenomics) has the enormous potential to enhance cancer decoding and act as a catalyst for digital precision medicine. Herein, we provide a comprehensive overview of the current framework and potential clinical applications of radiogenomics in patient care. We also highlight recent research advances to illustrate how radiogenomics can address common clinical problems in solid tumors such as breast cancer, lung cancer, and glioma. Finally, we analyze existing literature to outline challenges and propose solutions, while also identifying future research pathways. We believe that the perspectives shared in this survey will provide a valuable guide for researchers in the realm of radiogenomics aiming to advance precision oncology.
Vascularized Femoral Myo‐Periosteal Graft for Congenital Pseudarthrosis of the Tibia: A Case Report
Authors: Soldado Francisco , Rivas‐Nicolls Danilo , Rojas‐Neira Juliana , Sevilla‐Tirado Juan J. , Nguyen Trong‐Quynh , Knorr Jorge 
Published: September 2024

ABSTRACTPure vascularized periosteal transplants have been shown to be extremely effective at achieving rapid bone healing in children with biologically complex non‐union. Free tibial and fibular periosteal transplants are generally indicated when large periosteal flaps are necessary. We report using a vascularized femoral myo‐periosteal graft (VFMPG) to treat distal tibial osteotomy non‐union in a six‐year‐old boy with congenital pseudarthrosis of the tibia. The graft consisted of a 9 cm myo‐periosteal flap (after 50% of elastic retraction) that incorporated the vastus intermedius muscle and diaphyseal femoral periosteum nourished by the descending branch of the lateral circumflex femoral vessels. Plantaris medialis was used as a recipient vessel. Healing occurred 10 weeks after surgery. The patient resumed gait and sports activity without orthosis. No donor or recipient site complications occurred 17 months after surgery. Employing a VFMPG might be an alternative to other free or large vascularized periosteal flaps currently in use for complex pediatric non‐unions.