bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of early beta-blocker initiation in acute heart failure and cardiogenic shock: systematic review and meta-analysis
Authors: Sinardja Cyndiana Widia Dewi , Jagannatha Gusti Ngurah Prana , de Liyis Bryan Gervais , Kosasih Anastasya Maria 
Published: September 2024

Abstract
Background
The beta-blocker (BB) initiation in acute heart failure (AHF) patients is still controversial. Some show the benefit of BB employment in decreasing the mortality outcome. This study aims to assess the safety and efficacy of in-hospital and long-term outcomes of BB initiation in AHF hospitalized patients. We searched multiple databases examining the outcome of AHF patients who had administered BB as the therapy initiation. Primary outcomes were all-cause mortality, composite endpoint after BB initiation when hospitalized, and post-discharge all-cause mortality. The secondary outcomes were adverse events after in-hospital BB initiation, including hypotension and symptomatic bradycardia after BB initiation when hospitalization and rehospitalization.

Results
Eight cohort studies with 16,639 patients suffering from AHF and cardiogenic shock, with 9923 participants allocated to the early BB group and 6,713 patients in the control group. The follow-up durations ranged from 2 to 24 months. Early BB administration significantly reduced in-hospital composite endpoints (RR: 0.42; 95% CI (0.30–0.58); p < 0.001), in-hospital all-cause mortality (RR: 0.43; 95% CI (0.31–0.61); p < 0.001), discharge mortality (RR: 0.51; 95% CI (0.41–0.63); p < 0.001), and rehospitalization (RR: 0.57; 95% CI (0.44–0.74); p < 0.001). There were no discernible differences in in-hospital BB-related adverse events between the two groups (p = 0.13). Subgroup analyses conducted on AHF patients presenting with cardiogenic shock revealed no significant differences in in-hospital composite endpoint and in-hospital mortality, and similar results were shown in the naive BB population.

Conclusions
The BB initiation in AHF patients shows advantages in efficacy and safety outcome.
An enhanced stochastic error modeling using multi-Gauss–Markov processes for GNSS/INS integration system
Authors: Wu Youlong , Chen Shuai 
Published: September 2024

AbstractAngular random walk (ARW), rate random walk (RRW), and bias instability (BI) are the main noise types in inertial measurement units (IMUs) and thus determine the navigation performance of IMUs. BI is the flicker noise, which determines the noise level of an inertial sensor. The traditional error modeling approach involves modeling the ARW and BI processes as RRW or Gauss–Markov (GM) processes, and this approach is applied as a suboptimal filter in the global navigation satellite system (GNSS)/inertial navigation system (INS) extended Kalman filter (EKF). In this paper, the random error identification processes for white noise and colored noise for inertial sensors are separated using the Allan variance and power spectral density methods and the equivalence of the stochastic process differential equations of bias instability and a combination of multiple first-order GM processes are derived. A colored noise compensation method is proposed based on the enhanced EKF model. Experimental results demonstrate that, compared to traditional error models, our proposed model reduces positional drift error in dynamic testing from 195 to 49 m, enhancing positional accuracy by 40.2%. These findings confirm the potential and superiority of our method in complex navigation environments.
Development and evaluation of a monoclonal antibody-based competitive ELISA for detecting porcine deltacoronavirus antibodies
Authors: Wang Wei , Fan Baochao , Zhang Xuehan , Yang Shanshan , Zhou Junming , Guo Rongli , Zhao Yongxiang , Zhou Jinzhu , Li Jizong , Li Bin 
Published: September 2024

AbstractPorcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that can cause acute diarrhea and vomiting in newborn piglets and poses a potential risk for cross-species transmission. It is necessary to develop an effective serological diagnostic tool for the surveillance of PDCoV infection and vaccine immunity effects. In this study, we developed a monoclonal antibody-based competitive ELISA (cELISA) that selected the purified recombinant PDCoV nucleocapsid (N) protein as the coating antigen to detect PDCoV antibodies. To evaluate the diagnostic performance of the cELISA, 122 swine serum samples (39 positive and 83 negative) were tested and the results were compared with an indirect immunofluorescence assay (IFA) as the reference method. By receiver operating characteristic (ROC) curve analysis, the optimum cutoff value of percent inhibition (PI) was determined to be 26.8%, which showed excellent diagnostic performance, with an area under the curve (AUC) of 0.9919, a diagnostic sensitivity of 97.44% and a diagnostic specificity of 96.34%. Furthermore, there was good agreement between the cELISA and virus neutralization test (VNT) for the detection of PDCoV antibodies, with a coincidence rate of 92.7%, and the κ analysis showed almost perfect agreement (κ = 0.851). Overall, the established cELISA showed good diagnostic performance, including sensitivity, specificity and repeatability, and can be used for diagnostic assistance, evaluating the response to vaccination and assessing swine herd immunity.
Thyroid Autoimmunity is Associated with Dietary Fat Consumption
Authors: Xu Lulian , Liu Zhenzhen , Xu Xu , Wan Qiwen , Zhen Juanying , Jiang Li , Cheung Bernard Man Yung , Li Chao 
Published: September 2024

Abstract

Context
Dietary factors are crucial in the onset and development of autoimmune thyroid disease (AITD), but the relationship between specific fatty acids and AITD remains unexplored.

Methods
We analyzed the US National Health and Nutrition Examination Survey 2007 to 2012 data on 3949 men and 3964 women aged 20 years and over with valid data on antithyroid peroxidase antibodies (TPOAb), antithyroglobulin antibodies (TgAb), and details of fat intake using multivariable regression models to examine the relationship of fat intake and specific fatty acid intake with thyroid autoimmunity.

Results
Of the 7913 participants, 7.5% had TgAb seropositivity and 11.9% had TPOAb seropositivity. The seropositivity of TgAb and TPOAb was more common in low-fat intake participants. In the overall population and men, fats were associated with thyroid autoimmunity before and after full adjustment for age, ethnicity, body mass index, smoking status, and urine iodine concentration [total fat: odds ratio (OR) = 0.64, 95% confidence interval (CI): 0.49-0.83; saturated fatty acid: OR = 0.65, 95% CI: 0.51-0.84; monounsaturated fatty acid: OR = 0.65, 95% CI: 0.50-0.85; polyunsaturated fatty acid: OR = 0.76, 95% CI: 0.57-0.995, after full adjustment in men]. Some specific fatty acids followed a similar pattern. The association between fats and TgAb seropositivity was significant in the overall population and men. The association between fats and TPOAb seropositivity was only found in the overall population.

Conclusion
We found a strong association between fat consumption and thyroid autoimmunity in the overall population and men from the nationally representative population-based survey. Fat and fatty acid consumption may be of benefit to individuals with thyroid autoimmunity.
Point-of-Care Lung Ultrasound to Evaluate Lung Isolation During One-Lung Ventilation in Children: A Blinded Observational Feasibility Study
Authors: Moharir Alok , Yamaguchi Yoshikazu , Aldrink Jennifer H. , Martinez Andrea , Arce-Villalobos Mauricio , Yemele Kitio Sibelle Aurelie , Rice-Weimer Julie , Tobias Joseph D. 
Published: September 2024

BACKGROUND:
Minimally invasive thoracic surgical techniques require effective lung isolation using one-lung ventilation (OLV). Verification of lung isolation may be confirmed by auscultation, visual confirmation using fiberoptic bronchoscopy (FOB), or more recently, point-of-care ultrasound (POCUS). The aim of this study was to prospectively compare lung ultrasound with clinical auscultation to confirm OLV before thoracic surgery in pediatric patients.

METHODS:
This prospectively blinded feasibility study included 40 patients ranging in age from 0 to 20 years. After confirmation of lung separation by the primary anesthesia team using FOB, the sonographer and the auscultator, both blinded to the laterality of surgery and lung separation, entered the operating room. The sonographer evaluated for pleural lung sliding and the auscultator listened for breath sounds. Successful lung separation was definitively confirmed by direct visualization of lung collapse during the operation.

RESULTS:
In confirming effective single-lung ventilation, lung ultrasound had a diagnostic accuracy of 95% (95% confidence interval [CI], 82.7%–98.5%). In contrast, auscultation could only reliably confirm lung isolation with 68% accuracy (95% CI, 51.5%–80.4%). The McNemar test showed a statistically significant difference between the use of lung ultrasound and auscultation (P < .001). The median time to perform ultrasonography was 67 seconds (interquartile range [IQR], 46–142) and the median time to perform auscultation was 21 seconds (IQR, 10–32).

CONCLUSIONS:
Based on the initial results of our feasibility trial, lung ultrasound proved to be a fast and reliable method to verify single-lung ventilation in pediatric patients presenting for thoracic surgery with a high degree of diagnostic accuracy.
Intergenerational Transmission of Divorce in Sweden, 1920–2015
Authors: Stanfors Maria , Bergvall Martin 
Published: September 2024

Abstract
Many studies demonstrate an intergenerational transmission of divorce with a focus primarily on more recent decades; however, the extent to which this relationship is deeply rooted or has changed over time remains unclear. Explanations, including sociodemographic and interpersonal factors, have been offered as links between parental divorce and the stability of offspring's marriage. We use individual-level longitudinal data from the Scanian Economic-Demographic Database to estimate the intergenerational transmission of divorce among first marriages in Sweden over the period 1920–2015. Our investigation focuses on the correlation between parental divorce and offspring's divorce during the transition from a low- to a high-divorce regime. Findings reveal surprising stability in the transmission despite fundamental societal change over the years. Notably, the risk of divorce is highest when either the wife or both spouses have experienced parental divorce. Moreover, the transmission of divorce across time appears to be stronger and more stable for women than for men. These results suggest the intergenerational transmission of divorce is part of the divorce transition and highlight the role of women's independence in this intricate but not yet fully understood process.
Impact of Postoperative Chemotherapy on Survival in Patients with Primary Central Nervous System Lymphoma: A Study Based on the SEER Database
Authors: Chen YuShan , Zheng ShuiShun , Zheng ShunYong , Lin Hong , Wei LiZhen , Chen ShaoQiang 
Published: September 2024

Aims/Background We aimed to investigate the impact of postoperative chemotherapy (POCT) on survival in patients with primary central nervous system lymphoma (PCNSL) using data from the Surveillance, Epidemiology, and End Results (SEER) database. Methods This study included 786 PCNSL patients, of which 605 received chemotherapy after surgery, and 181 did not. Data from the SEER registry database (2007–2020) were used to analyze PCNSL. Baseline information, including age, sex, race, marital status, primary tumour site, histological type, summary stage, surgical procedures, chemotherapy, and radiotherapy, was analyzed. Propensity Score Matching (PSM) (1:1) was employed to balance the effects of confounding variables between the two groups. Subsequently, Cox regression and bidirectional stepwise regression were used to identify independent prognostic factors. Kaplan-Meier (K-M) survival curves were constructed to assess the impact of POCT on patient prognosis. Additionally, two cases of PCNSL with typical magnetic resonance imaging appearances were presented. Results Multivariate Cox regression results revealed that age older than 60 years (hazard ratio [HR] = 1.786; 95% confidence interval [CI]: 1.272–2.509; p = 0.001) and absence of POCT (HR = 2.841; 95% CI: 2.159–3.738; p < 0.001) were independent prognostic risk factors, while primary tumour locations in the meninges (HR = 0.136; 95% CI: 0.032–0.569; p = 0.006) and other nervous system regions (HR = 0.552; 95% CI: 0.326–0.936; p = 0.027), as well as histological morphologies such as diffuse large B-cell lymphoma (HR = 0.233; 95% CI: 0.128–0.425; p < 0.001) and non-Hodgkin lymphoma (HR = 0.559; 95% CI: 0.356–0.876; p = 0.011), were associated with favourable patient outcomes. K-M curves demonstrated that the group undergoing POCT had a significantly more favourable prognosis compared to the non-POCT group, before (HR = 0.454; 95% CI: 0.343–0.600; p < 0.0001) or after PSM (HR = 0.580; 95% CI: 0.431–0.780; p < 0.0001). For patients with PCNSL, those with tumours located in the infratentorial region (HR = 0.231; 95% CI: 0.078–0.682; p = 0.046), supratentorial region (HR = 0.250; 95% CI: 0.163–0.383; p < 0.0001), overlapping brain regions (HR = 0.201; 95% CI: 0.056–0.727; p = 0.0058), and those who underwent biopsy (HR = 0.740; 95% CI: 0.463–1.182; p = 0.003), subtotal resection (STR) (HR = 0.490; 95% CI: 0.265–0.906; p = 0.0064), or gross total resection (GTR) (HR = 0.613; 95% CI: 0.292–1.287; p = 0.0003) had better prognoses in the postoperative chemotherapy group compared to the non-chemotherapy group. Conclusion POCT significantly improves the prognosis of PCNSL patients and identifies the characteristics of the benefiting population. This information aids clinical practitioners in designing personalized treatment plans for individuals and advancing precise treatment.
Theory-based and evidence-based nursing interventions for the prevention of ICU-acquired weakness in the intensive care unit: A systematic review
Authors: Xu Qin , Tan Jie , Wang Yixuan , Tang Manli 
Published: September 2024

Objectives
To synthesise and map the evidence of a theory- and evidence-based nursing intervention for the prevention of ICU-acquired weakness and evaluate its effectiveness in terms of the incidence of ICU-acquired weakness, incidence of delirium, and length of hospital stay.

Methods
We searched PubMed, CINAHL, MEDLINE, Academic Search Complete, Embase, Scopus, Web of Science and the Cochrane Library from database inception to November 2023. The eligible studies focused on critically ill patients in the intensive care unit, used a theory- and evidence-based nursing intervention, and reported the incidence of ICU-acquired weakness and/or used the Medical Research Council Scale. The methodological quality of the included studies was critically appraised by two authors using the appropriate Joanna Briggs Institute appraisal tool for randomised controlled trials, quasi-experimental studies, and cohort studies. Additionally, the weighted kappa coefficient was used to assess inter-rater agreement of the quality assessment. Data were reported using a narrative synthesis. This systematic review was registered by the International Prospective Register of Systematic Review (PROSPERO; CRD42023477011).

Results
A total of 5162 studies were initially retrieved, and 9 studies were eventually included after screening. This systematic review revealed that preventive nursing interventions for ICU-acquired weakness mainly include (a) physiotherapy, including neuromuscular electrical stimulation and early rehabilitation, and (b) nutritional support. In addition, (c) airway management, (d) sedation and analgesia management, (e) complication prevention (delirium, stress injury and deep vein thrombosis prevention), and (f) psychological care were also provided. The theories are dominated by goal-oriented theories, and the evidence is mainly the ABCDE bundle in the included studies. The results show that theory- or evidence-based nursing interventions are effective in reducing the incidence of ICU-acquired weakness (or improving the Medical Research Council Scale scores), decreasing the incidence of delirium, shortening the length of hospital stay, and improving patients’ self-care and quality of life.

Conclusion
Theory- and evidence-based nursing interventions have good results in preventing ICU-acquired weakness in critically ill patients. Current nursing interventions favour a combination of multiple interventions rather than just a single intervention. Therefore, preventive measures for ICU-acquired weakness should be viewed as complex interventions and should be based on theory or evidence. This systematic review is based on a small number of trials. Thus, more high-quality randomised controlled trials are needed to draw definitive conclusions about the impact of theory- and evidence-based nursing interventions on the prevention of ICU-acquired weakness.
Estrogen‐dependent gene regulation: Molecular basis of TIMP‐1 as a sex‐specific biomarker for acute lung injury
Authors: Almuntashiri Sultan , Dutta Saugata , Zhu Yin , Gamare Siddhika , Ramírez Gustavo , Irineo‐Moreno Valeria , Camarena Angel , Regino Nora , Campero Paloma , Hernández‐Cardenas Carmen M. , Rodriguez‐ Reyna Tatiana S. , Zuñiga Joaquin , Owen Caroline A. , Wang Xiaoyun , Zhang Duo 
Published: September 2024

AbstractIncreased circulating tissue inhibitor of metalloproteinases‐1 (TIMP‐1) levels have been observed in patients with acute lung injury (ALI). However, the sex‐specific regulation of TIMP‐1 and the underlying molecular mechanisms have not been well elucidated. In this study, we found that plasma TIMP‐1 levels were significantly higher in COVID‐19 and H1N1 patients compared with those in healthy subjects (n = 25). TIMP‐1 concentrations were significantly different between males and females in each disease group. Among female but not male patients, TIMP‐1 levels significantly correlated with the PaO2/FiO2 ratio and hospital length of stay. Using the mouse model of ALI induced by the H1N1 virus, we found that TIMP‐1 is strikingly induced in PDGFRα‐positive cells in the murine lungs. Moreover, female mice showed a higher Timp‐1 expression in the lungs on day 3 postinfection. Mechanistically, we observed that estrogen can upregulate TIMP‐1 expression in lung fibroblasts, not epithelial cells. In addition, overexpression of estrogen receptor α (ERα) increased the TIMP‐1 promoter activity. In summary, TIMP‐1 is an estrogen‐responsive gene, and its promoter activity is regulated by ERα. Circulating TIMP‐1 may serve as a sex‐specific marker, reflecting the severity and worst outcomes in female patients with SARS‐CoV2‐ and IAV‐related ALI.
Solutions to the coupled Schrödinger systems with steep potential well and critical exponent
Authors: Lv Zongyan , Tang Zhongwei 
Published: September 2024

Abstract
In the present paper, we consider the coupled Schrödinger systems with critical exponent:

−
Δ

u

i

+

λ

V

i

(

x

)

+

a

i

u

i

=

∑

j
=
1

d

β

i
j

u

j

3

u

i

u

i

in

R

3

,

u

i

∈

H

1

(

R

N

)

,

i
=
1,2
,
…
,
d
,

$$\begin{cases}-{\Delta}{u}_{i}+\left(\lambda {V}_{i}\left(x\right)+{a}_{i}\right){u}_{i}=\sum _{j=1}^{d}{\beta }_{ij}{\left\vert {u}_{j}\right\vert }^{3}\left\vert {u}_{i}\right\vert {u}_{i}\quad \,\text{in}\,{\mathbb{R}}^{3},\quad \hfill \\ {u}_{i}\in {H}^{1}\left({\mathbb{R}}^{N}\right),\quad i=1,2,\dots ,d,\quad \hfill \end{cases}$$

where d ≥ 2, β

ii
> 0 for every i, β

ij
= β

ji
when i ≠ j, λ > 0 is a parameter and

0
≤

V

i

∈

L

loc

∞

R

N

$0\le {V}_{i}\in {L}_{\text{loc\,}}^{\infty }\left({\mathbb{R}}^{N}\right)$

have a common bottom int

V

i

−
1

(

0

)

${V}_{i}^{-1}\left(0\right)$

composed of

ℓ

0

ℓ

0

≥
1

${\ell }_{0}\left({\ell }_{0}\ge 1\right)$

connected components

Ω

k

k
=
1

ℓ

0

${\left\{{{\Omega}}_{k}\right\}}_{k=1}^{{\ell }_{0}}$

, where int

V

i

−
1

(

0

)

${V}_{i}^{-1}\left(0\right)$

is the interior of the zero set

V

i

−
1

(

0

)

=

x
∈

R

N

∣

V

i

(

x

)

=
0

${V}_{i}^{-1}\left(0\right)=\left\{x\in {\mathbb{R}}^{N}\mid {V}_{i}\left(x\right)=0\right\}$

of V

i
. We study the existence of least energy positive solutions to this system which are trapped near the zero sets int

V

i

−
1

(

0

)

${V}_{i}^{-1}\left(0\right)$

for λ > 0 large for weakly cooperative case

β

i
j

>
0

s
m
a
l
l

$\left({\beta }_{ij}{ >}0 \mathrm{s}\mathrm{m}\mathrm{a}\mathrm{l}\mathrm{l}\right)$

and for purely competitive case

β

i
j

≤
0

$\left({\beta }_{ij}\le 0\right)$

. Besides, when d = 2, we construct a one-bump fully nontrivial solution which is localised at one prescribed components

Ω

k

k
=
1

ℓ

${\left\{{{\Omega}}_{k}\right\}}_{k=1}^{\ell }$

for large λ.
Trigonometric integrals evaluated in terms of Riemann zeta and Dirichlet beta functions
Authors: Li Jing , Chu Wenchang 
Published: September 2024

Abstract
Three classes of trigonometric integrals involving an integer parameter are evaluated by the contour integration and the residue theorem. The resulting formulae are expressed in terms of Riemann zeta function and Dirichlet beta function. Several remarkable integral identities are presented.
Association of polymorphisms in FBN1, MYH11, and TGF-β signaling-related genes with susceptibility of sporadic thoracic aortic aneurysm and dissection in the Zhejiang Han population
Authors: Yu Shasha , Huang Lujie , Ren Jianfei , Zhang Xiaoying 
Published: September 2024

Abstract

Background
Sporadic thoracic aortic aneurysm and dissection (sTAAD) is a complicated vascular disease with a high mortality rate. And its genetic basis has not been fully explored.

Method
Here, 122 sTAAD patients and 98 healthy individuals were recruited, and 10 single nucleotide polymorphisms were selected and analyzed (FBN1 rs10519177, rs1036477, rs2118181, MYH11 rs115364997, rs117593370, TGFβ1 rs1800469, TGFβ2 rs900, TGFβR2 rs764522, rs1036095, and rs6785385). Moreover, multiple logistic regression analysis was used to evaluate gene–environment interactions.

Results
We identified that TGFβR2 rs1036095 dominant model CC + CG genotype (GT) (P = 0.004) may be a factor of increased risk of sTAAD, especially for women. FBN1 rs1036477 recessive model AA GT (P = 0.009) and FBN1 rs2118181 dominant model CC + CT GT (P = 0.009) were correlated to an increased death rate in sTAAD men patients. Gene–environment interactions indicated TGFβR2 rs1036095 dominant model (CC + CG)/GG to be a higher-risk factor for sTAAD (odds ratio = 3.255; 95% confidence interval: 1.324–8.000, P = 0.01).

Conclusions
TGFβR2 rs1036095, FBN1 rs1036477, and FBN1 rs2118181 were identified as factors of increased risk of sTAAD. Gene–environment interactions were associated with the risk of sTAAD.