bluuebunny/crossref_metadata_2025_split huggingface dataset:
Identification of potential auxin response candidate genes for soybean rapid canopy coverage through comparative evolution and expression analysis
Authors: Ferreira Neres Deisiany , Taylor Joseph S. , Bryant John A. , Bargmann Bastiaan O. R. , Wright R. Clay 
Published: October 2024

IntroductionThroughout domestication, crop plants have gone through strong genetic bottlenecks, dramatically reducing the genetic diversity in today’s available germplasm. This has also reduced the diversity in traits necessary for breeders to develop improved varieties. Many strategies have been developed to improve both genetic and trait diversity in crops, from backcrossing with wild relatives, to chemical/radiation mutagenesis, to genetic engineering. However, even with recent advances in genetic engineering we still face the rate limiting step of identifying which genes and mutations we should target to generate diversity in specific traits.MethodsHere, we apply a comparative evolutionary approach, pairing phylogenetic and expression analyses to identify potential candidate genes for diversifying soybean (Glycine max) canopy cover development via the nuclear auxin signaling gene families, while minimizing pleiotropic effects in other tissues. In soybean, rapid canopy cover development is correlated with yield and also suppresses weeds in organic cultivation.Results and discussionWe identified genes most specifically expressed during early canopy development from the TIR1/AFB auxin receptor, Aux/IAA auxin co-receptor, and ARF auxin response factor gene families in soybean, using principal component analysis. We defined Arabidopsis thaliana and model legume species orthologs for each soybean gene in these families allowing us to speculate potential soybean phenotypes based on well-characterized mutants in these model species. In future work, we aim to connect genetic and functional diversity in these candidate genes with phenotypic diversity in planta allowing for improvements in soybean rapid canopy cover, yield, and weed suppression. Further development of this and similar algorithms for defining and quantifying tissue- and phenotype-specificity in gene expression may allow expansion of diversity in valuable phenotypes in important crops.
How ChatGPT transformed teachers: the role of basic psychological needs in enhancing digital competence
Authors: Zhou Jinshan , Shen Lihan , Chen Weibang 
Published: October 2024

IntroductionWith the rapid development of ChatGPT, its application in the field of education has garnered widespread attention. This study aims to explore the impact of ChatGPT on teachers’ digital competence (TDC) and the mediating role of basic psychological needs satisfaction (BPNS).MethodsThe study was conducted in China, collecting questionnaire data from 632 teachers through the QuestionStar platform. Structural equation modeling was employed using SmartPLS 4.0 to examine the effects of ChatGPT usage on TDC and its relationship with BPNS.ResultsThe findings indicate that ChatGPT has a significant effect on TDC, primarily through the fulfillment of competence and relatedness needs, while the impact of autonomy on TDC was not significant.DiscussionThe results indicate that ChatGPT can enhance TDC and improve intrinsic motivation by satisfying their basic psychological needs. It is recommended that the design of educational tools consider teachers’ psychological needs to promote their professional development and well-being. This provides practical guidance for educational institutions, emphasizing the importance of teachers in the digital transformation process.
Negative interaction between emotional vulnerability and depressive symptoms may heighten suicidal ideation among Japanese university students: a cross-sectional study
Authors: Yamaguchi Shinji , Nagamine Daiki , Murofushi Yuka , Matsuda Kojiro 
Published: October 2024

IntroductionStudies examining the relationships among suicidal ideation, emotional vulnerability, and depressive symptoms are scarce. This study examined the effects of emotional vulnerability and depressive symptoms on suicidal ideation among Japanese university studentsMethodsA questionnaire survey was conducted with 370 Japanese university students. Data were analyzed using descriptive statistics and multiple regression analysisResultsIn the multiple regression analysis, depressive symptoms were significant (β = .46, p &lt;.001) but emotional vulnerability was not (β = .05, p = .318). A significant interaction emerged between emotional vulnerability and depressive symptoms (β = .22, p &lt;.001). The model’s R2 value was.31 (p &lt;.001). Simple slopes tests revealed the impact of depressive symptoms on suicidal ideation, even with low emotional vulnerability (b = .06, β = .27, p &lt;.001), and a higher impact with high emotional vulnerability (b = .15, β = .65, p &lt;.001)DiscussionThe negative interaction between emotional vulnerability and depressive symptoms may heighten suicidal ideation among Japanese university students. Interventions targeting emotional vulnerability may help reduce suicidal ideation and achieve lower suicide rates.
Association between the cardiometabolic index and osteoporosis: a cross-sectional study of the NHANES
Authors: Li Deyan , Li Jinli , Li Yijun , Dong Wei , Lin Zhuofeng 
Published: October 2024

BackgroundThe cardiometabolic index (CMI) is a novel metabolic biomarker, but research on its association with osteporosis (OP) is limited. The objective of this research was to clarify the relationship between CMI and OP in the older adult population of the United States.MethodsThis study conducted a cross-sectional analysis using NHANES data 2007–2018 with exclusion of 2011–2012 and 2015–2016 cycles. Logistic regression was used to investigate the relationship between CMI and OP prevalence. Restricted cubic spline curve (RCS) and threshold saturation analyses were performed to explore the nonlinear association between CMI and OP prevalence. Subgroup analyses, sensitivity analyses, and additional analyses were conducted to ensure the robustness and reliability of the findings.ResultsThe study included 4,191 participants, revealing that those with OP had significantly lower CMI levels. Logistic regression revealed a strong inverse correlation between Log CMI and OP (OR = 0.72, 95% CI = 0.59–0.88), which persisted after adjusting for covariates. RCS analysis revealed a nonlinear inverse relationship with the critical threshold at CMI = 0.93. Below this threshold, each unit increase in CMI was associated with a 37% reduction in OP prevalence, but changes above this threshold were not significant. Subgroup and sensitivity analyses confirmed the robustness of the findings.ConclusionElevated CMI exhibited a robust inverse correlation with the prevalence of OP in the older adult U.S. population. Maintaining a moderate CMI significantly diminishes the risk of developing OP.
Fostering adaptation to climate change among farmers in Pakistan: the influential role of farmers’ climate change knowledge and adaptive capacity
Authors: Mustafa Ghulam , Alotaibi Bader Alhafi 
Published: October 2024

IntroductionAdaptation to climate change (ACC) is imperative to avoid deleterious consequences of climate change in agriculture. However, the uptake of adaptation measures has been slow among farmers because of low adaptive capacity (AC) in developing countries, particularly in Pakistan. Farmers and their supporting institutions have been successful in introducing technological innovations to respond and adapt to environmental challenges. The present study intended to determine the impact of farming technologies, along with human, financial, social, physical, natural, and climate information resources that support AC and hence ACC.MethodsThe study collected data from 360 farmers in Punjab through a multi-stage random sampling technique. A binary logit model and odds ratio were used to identify the factors affecting ACC. The study also utilized correlation tests to show the correlation between each pair of variables included in the analysis.ResultsThe results indicated that physical capital such as ownership of tube wells, transportation, and sowing and harvesting tools by the farmers builds farmers’ AC and consequently determines the ACC such as change crop variety (CCV), change crop type (CCT), change planting date (CPD), soil conservation (SC), water conservation (WC), and diversification strategies (DSs). The findings also revealed that human capital (age, education, family size, and labor), financial capital (off-farm employment, access to the marketing of produce, and agricultural credit), social capital (farmers-to-farmers extensions, access to extension services, and the farm association membership), and natural capital (land ownership, tenancy status, and the location of the farm) were importantly related to farm households’ ACC strategies. The odds (likelihood) of adaptation were higher for the users of farm technology as compared to non-users.DiscussionThe analysis conducted in this study showed that climate information resources amplify the adaptation to climate change: technology allows farming to be much more efficient, while climate change knowledge (CCK) self-motivates farmers to adopt more ACC measures. Our findings provide evidence that suggests the need to provide credits and financial support for farming technologies that speed up the ACC in the long run, while in the short run, climate information should be spread among farming communities.
O futuro da gestão de projetos na PMPR: Inteligência Artificial como ferramenta estratégica
Authors: Rasera Luciano Savogin 
Published: October 2024

O objeto deste estudo se destina a explorar o potencial da Inteligência Artificial - IA para otimização da gestão de projetos na Polícia Militar do Paraná - PMPR, assim aumentando a eficiência, reduzindo custos e aprimorando a qualidade nesta área que tem ganhado cada dia mais importância para a corporação. A pesquisa, baseada em revisão bibliográfica do assunto, de forma sistemática, identifica as tecnologias existentes, como machine learning e automação de processos, entre outras promissoras para utilização na PMPR. Apesar de desafios como resistência da tropa à mudança, a cultura institucional, a qualidade dos dados atualmente disponíveis, destaca-se os benefícios da utilização da tecnologia, incluindo alocação otimizada de recursos, tomada de decisões mais assertivas e maior transparência. Ao final do estudo se propõe a implementação da IA, por meio de encomenda tecnológica, o que pode transformar a gestão de projetos e outras áreas da PMPR, automatizando tarefas e fornecendo possibilidades valiosas de inovações. A abordagem deste estudo visa contribuir para a modernização da gestão pública e possibilitar o olhar do uso da IA na melhoria dos serviços prestados, inicialmente na gestão de projetos, mas podendo chegar a atividade-fim da corporação.
من خصائص المذهب المالكي: اعتبار قاعدة: ما جرى به العمل، مفهومها، حجيتها، ضوابطها، وأثرها في معالجة قضايا العصر
Authors: المحمد خلف محمد 
Published: October 2024

تتمثل فكرة البحث في تميّز المذهب المالكي بخصائص، جعلت منه مرجعاً للقضاة والمفتين؛ لتنوع مصادره وكثرتها، منها: الاستدلال بقاعدة، ما جرى عليه العمل. وهي عمل القضاة، والمفتين المعتمدين بقول مرجوح لمصلحة مناسبة، ويجري هذا العمل، وتكمن أهمية البحث في توظيف هذه القاعدة، وتنزيلها على الواقع، لأن الاعتماد على القول الراجح، أو المشهور، قد يؤدي إلى وقوع الناس في مشقة، وبالأخص في هذا العصر. ومن هنا ظهرت الإشكالية، ألا وهي ما مدى جواز ترك القول الراجح أو المشهور، والأخذ بالقول الضعيف؟ وهل في الأخذ به خروج عن المذهب المالكي؟ ويهدف البحث إلى تجلية موقف فقهاء المالكية من الأخذ بهذه القاعدة، وبيان شروطها وضوابطها، سالكاً في كتابته المنهج الاستقرائي والتحليلي، مُدَعماً ذلك بالمسائل الفقهية من المذهب المالكي، التي فيها أقوال راجحة، أو مشهورة ومرجوحة، ثم عَدل الفقهاء فيها إلى الإفتاء بالقول المرجوح، لسبب معتبر. ومن نتائجه: هذه القاعدة مؤصلة في المذهب المالكي، تدل على التطور والنمو المنهجي للفقه المالكي، وفق قواعد المذهب، تُعالِجُ كثيراً من الأحكام الشرعية للمسائل الفقهية في هذا العصر، مثل مسألة بيع الصفقة وغيرها. وتوصي الدراسة المجامع الفقهية ومراكز الفتوى في القضايا المعاصرة للمسلمين في أوروبا، بالاعتماد على هذا المنهج للضرورة، وتفعيله في معالجة النوازل.
Contribution to the study of mastitis in camels in southeastern Algeria
Authors: Anes Dadda , Abdellah Mohamed Cherif , Anis Abbas , Ibtissem Rezaiguia , Issad Nassima Ait , Khelef Djamel 
Published: October 2024

Mastitis is an important disease on camel farms in Algeria, affecting camels at different stages of lactation. This study includes several camel farms in the wilaya of Oued Souf and Ouergla in southeastern Algeria, where the consumption of raw camel milk is important, but it can expose consumers to the risk of zoonotic agents, which are currently underestimated. The objective of the study is to estimate the prevalence of the disease and detect the bacteria involved. The number of animals in the herds surveyed was 56 dromedaries.The CMT test revealed that mastitis had a prevalence of 26%; it was most prevalent in females aged between 14 and 35 years (57%), and the majority of cases occurred in summer with a prevalence of 38% compared with 19% in spring. Bacteriological analysis showed that staphylococcus aureus was the main cause of subclinical mastitis (79%), followed by Escherichia coli (21%). However, in the clinical form we found that E.coli is the most involved, with a prevalence of 75%, followed by staphylococcus aureus in 25% of cases. The bacterial strains isolated were resistant to certain antibiotics such as streptomycin and ofloxacin, but were also sensitive to amoxicillin and sulphamethoprim.
Pharmacoeconomic Analysis of the Use of C1-inhibitor in Treatment of Hereditary Angioedema: Clinical Trial Data in Belarus
Authors: Гурьянова И.Е. , Романова И.С. , Кожанова И.Н. , Белевцев М.В. , Семёнов А.В. , Солнцева А.В. 
Published: October 2024

Наследственный ангионевротический отек (НАО) представляет собой генетически опосредованное и угрожающее жизни заболевание, клинически проявляющееся рецидивирующими острыми приступами отеков слизистой оболочки, поражающих любые участки тела, которое возникает в среднем у одного из 30 000 человек. В 99% всех случаев это заболевание ассоциировано с недостаточностью С1-ингибитора (количественной – тип I или функциональной – тип II), вызванной патогенетическими нарушениями в гене SERPING1, кодирующем белок С1-ингибитора. Патофизиологическая основа НАО – это прежде всего сосудистая реакция на чрезмерный локальный синтез брадикинина. У пациентов с НАО часто встречаются острые абдоминальные боли, имитирующие клиническую картину «острого живота», ввиду чего им могут проводиться ненужные оперативные вмешательства. Наиболее опасными являются отеки верхних дыхательных путей, которые могут привести к удушью и смерти, если вовремя не применить адекватную терапию. Актуальность клинической проблемы пациентов с НАО обусловлена сложностями диагностики и лечения, а также серьезным и всесторонним влиянием заболевания на жизнь пациентов и их близких. Одним из лекарственных препаратов, имеющих доказательства в профилактике и лечении приступов у пациентов с НАО, является С1-ингибитор (человеческий). В соответствии с действующими национальными и международными нормативными документами, определяющими порядок оказания помощи пациентам с НАО, проведен фармакоэкономический анализ применения лекарственного препарата С1-ингибитор (человеческий) в купировании приступа НАО у взрослых пациентов и детей старше 2 лет.
Hereditary angioedema (HAE) is life-threatening genetic disease, clinically manifested by recurrent acute mucosal edema affecting any part of the body, which occurs on average in one in 30,000 people. In 99% of cases, HAE is associated with quantitative (type 1) or functional (type 2) C1-inhibitor deficiency, caused by pathogenic variants in the SERPING1 gene, encoding protein C1-inhibitor. The pathophysiology of HAE is due to a vascular reaction to excessive local synthesis of bradykinin. Patients with HAE often experience acute abdominal pain clinically similar to an acute abdominal syndrome, due to which unnecessary surgical interventions are performed. Potentially life threatening is upper airway edema, which can lead to asphixy and death, if therapy is not assigned in time. The difficulty of diagnosing and treating patients with hereditary angioedema has a major impact on the lives of patients and their relatives. One of the medicine that has evidence in the prevention and treatment of edema in patients with HAE is a C1-inhibitor (human). Based on national and international regulatory documents, a pharmacoeconomic analysis of the use of the C1-inhibitor (human) for the treatment in adult patients and children over 2 years of age with HAE was conducted.
Management of Patients with Recurrent Vertigo
Authors: Марьенко И.П. 
Published: October 2024

Головокружение может быть симптомом многих соматических, неврологических, психических заболеваний и заболеваний лор-органов. Сложности диагностики причин головокружения обусловлены трудностями в интерпретации жалоб и анамнеза пациентов, спонтанного и провокационного нистагма, что может привести к полипрагмазии. Острый приступ головокружения является состоянием, требующим обширного дифференциального диагноза, включающего как доброкачественные, так и серьезные состояния, требующие неотложного лечения. Установление диагноза у пациента с острым приступом головокружения основано на соответствии или несоответствии острого головокружения признакам острого нарушения мозгового кровообращения или периферической вестибулопатии. Для уточнения типа головокружения, оценки эффективности лечения разработаны опросник выявления типа головокружения и дневник пациента с головокружением. Лечение включает купирование приступа головокружения, лечение причины головокружения, коррекцию психоэмоциональных расстройств, профилактику рецидивов головокружения, вестибулярную реабилитацию.
Vertigo can be a symptom of many somatic, neurological, mental diseases and diseases of the ORL organs. Difficulties in diagnosing the causes of vertigo are due to difficulties in interpreting complaints and patient’s history, spontaneous and provocative nystagmus, which can lead to polypharmacy. An acute attack of vertigo is a condition that requires an extensive differential diagnosis, including both benign and serious conditions requiring emergency treatment. A diagnosis has been made in a patient with an acute attack of vertigo, based on the correspondence or inconsistency of acute vertigo with a severe cerebrovascular accident or peripheral vestibulopathy. To clarify the type of vertigo and assess the effectiveness of treatment, surveys of the type of vertigo and a diary of a patient with vertigo have been developed. Treatment includes relief of an attack of vertigo, treatment of the cause of vertigo, correction of psycho-emotional disorders, prevention of relapses of vertigo, and vestibular rehabilitation.
Hyperuricemia and Cardiovascular Diseases
Authors: Мацкевич С.А. , Романова И.С. , Кожанова И.Н. , Чак Т.А. , Пархомец М.И. 
Published: October 2024

В статье представлен обзор литературы, освещающей роль гиперурикемии как фактора риска развития сердечно-сосудистых заболеваний и одного из факторов прогрессирования существующего заболевания сердечно-сосудистой системы. Приведены эпидемиологические сведения о взаимосвязи гиперурикемии и поражения сердца. Представлены механизмы повреждающего действия мочевой кислоты на сердечно-сосудистую систему, полученные в эксперименте и клинических условиях.
The article provides a review of the literature highlighting the role of hyperuricemia as a risk factor for the development of cardiovascular diseases and one of the factors in the progression of existing cardiovascular disease. Epidemiological information on the relationship between hyperuricemia and heart damage is provided. The mechanisms of the damaging effect of uric acid on the cardiovascular system, obtained in experiments and clinical conditions, are considered.
IN STAVROPOL NIKOLAY IVANOVICH PIROGOV NOT OPERATED
Authors: Карташев А.В. , Дугинец С.М. 
Published: October 2024

Рассматриваются подробности пребывания великого русского хирурга Н.И. Пирогова в Ставрополе в 1847 г., в период его поездки в действующую армию на Кавказ. На основе достоверных исторических источников доказывается, что Н.И. Пирогов операций в Ставропольском военном госпитале не проводил.
The details of the stay of the great Russian surgeon N.I. Pirogov in Stavropol in 1847 during his trip to the army in the Caucasus. On the basis of reliable historical sources, it is proved that N.I. Pirogov did not perform operations in the Stavropol military hospital.
HISTORICAL ASPECT OF THE EUROPEAN PRACTICE OF PRESERVING THE HISTORICAL AND CULTURAL PHARMACEUTICAL HERITAGE
Authors: Мамаева Е.И. 
Published: October 2024

В статье дано определение историко-культурному фармацевтическому наследию, определены основы дифференциации историко-культурного медицинского и фармацевтического наследия, приведены примеры европейских акторов сохранения, изучения и популяризации историко-культурного фармацевтического наследия.
The article defines the historical and cultural pharmaceutical heritage, defines the basis for differentiating the historical and cultural medical and pharmaceutical heritage, and provides examples of European actors in the preservation, study and popularization of the historical and cultural pharmaceutical heritage.
DEMOGRAPHIC POTENTIAL OF SIBERIA XVI – BEGINNING XIX CENTURIES
Authors: Гайдаров Г.М. , Алексеевская Т.И. 
Published: October 2024

В статье представлена характеристика демографических процессов на территории Сибири. Отмечена динамика численности пришлого и коренного населения, его состав, расселение, показатели рождаемости и смертности.
The article presents the characteristics of demographic processes on the territory of Siberia. The dynamics of the number of newcomers and indigenous people, its composition, resettlement, fertility and mortality rates are noted.
CHARITABLE PERFORMANCES FOR INSUFFICIENT PUPILS OF THE UFA GOVERNMENT ZEMSKAYA FELDSHER’S OBSERVING SCHOOL
Authors: Даутбаев Д.Г. 
Published: October 2024

Доступность среднего медицинского образования привела к тому, что среди учениц Уфимской фельдшерско-акушерской школы оказалось много учащихся из бедных сословий, не имевших достаточных материальных средств. Для их поддержки попечительный совет школы и Общество любителей пения, музыки и драматического искусства организовывали благотворительные спектакли, которые проходили ежегодно с 1909 по 1914 г. Материалы Центрального государственного исторического архива Республики Башкортостан проливают свет на то, где и как организовывались концерты, какие суммы при этом удавалось собрать для недостаточных учениц. Благодаря этому становится ясно, что спектакли помогли помочь в получении фельдшерского образования многим ученицам Уфимской фельдшерско-акушерской школы.
The availability of secondary medical education led to the fact that many students of the Ufa paramedic and midwifery school from the poor classes did not have sufficient material resources. To support them, the school’s board of trustees and the Society of Singing, Music and Dramatic Arts organized charitable performances, which were held annually from 1909 to 1914. The materials of the central state historical archive of the Republic of Bashkortostan shed light on where and how the concerts were organized, how much money was collected for the insufficient students. Thanks to this, it becomes clear that the performances helped many students of the Ufa Medical Assistant and Obstetric School in obtaining a medical assistant’s education.