bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thermal Shrinking of Biopolymeric Hydrogels for High Resolution 3D Printing of Kidney Tubules
Authors: Viola Martina , Valverde Marta G. , Bernal Paulina Nuñez , van Trijp Jacobus P. , Hak Jaimie , Marco Greta Di , Neumann Myriam , Schuurmans Carl. C.L. , van Nostrum Cornelus F. , Masereeuw Rosalinde , Mihăilă Silvia M. , Malda Jos , Levato Riccardo , Vermonden Tina 
Published: October 2024

AbstractThe effective replication of microtubular structures in tissue engineering remains a great challenge. In this study, the temperature‐responsive characteristics of poly(N‐isopropylacrylamide) (pNIPAM) to create intricate, high‐resolution tubular structures through a shrinking mechanism is investigated by exploring 2 thermosensitive hydrogels–gelatin methacryloyl (gelMA) and silk fibroin methacryloyl (silkMA)–combined with pNIPAM. Systematic investigations revealed precise control of shrinking behavior at elevated temperatures (33–37 °C) as a function of polymer concentration. The hydrogel sizes reduce by ≈15% from room temperature (RT) to 33 °C and ≈40% from RT to 37 °C for both hydrogel types. The shrinking affects the mechanical properties, increasing the compressive modulus by ≈2.8‐fold for gelMA‐pNIPAM gels and ≈5.1‐fold for silkMA‐pNIPAM gels at 37 °C. Combined with volumetric printing, these materials achieve resolution enhancements of ≈20% for positive features and ≈70% for negative features, enabling the creation of complex, high‐resolution structures within seconds, with open channels (≈50 µm). GelMA‐pNIPAM hydrogels show better cell compatibility compared to silkMA‐pNIPAM hydrogels, promoting cell adhesion and viability. This study demonstrates the thermosensitive hydrogels' capability to engineer intricate, high‐resolution tubular structures with volumetric printing–an efficient route to fabricate microenvironments mimicking native tissues with potential for developing relevant in vitro models.
Photothermal‐Electric Excited Droplet Multibehavioral Manipulation
Authors: Jing Xueshan , Chen Huawei , Shang Xiaopeng , Zhang Liwen , Zhao Song , Zhou Xinzhao , Liu Xiaolin , Wang Zelinlan , Wang Yan , Du Wenxin , Guo Yurun , Jiang Lei 
Published: October 2024

AbstractThe light‐excited droplet manipulation is crucial in diverse industrial and health domains, owning to the merits of real‐time control and noncontact operation. However, strong driving forces and high‐precision maneuverability for splitting or mixing are still the challenges. Here a novel concept of configurating pyroelectric crystal surface is put forward to carry out multifunctional manipulation of the droplet by optical‐thermal‐electrical effect. Dipole‐like electric charge distribution is excited around the light spot to generate sharper inversion of electric field gradient and 10‐fold stronger dielectrophoretic （DEP） force than conventional photopyroelectric approaches. Both the stable mode and metastable‐oscillation mode are found and can be positively used to make on‐demand sliding and inside mixing of droplets. Especially, various droplets with the surface tension ranging from 25.7 to 85.4 mN m−1 can be split by light. The present droplet manipulation technique demonstrates its promising applications in cargo transportation, combinatorial chemistry and biomedical analysis.
Engineering Coordinatively Unsaturated Metal Sites in 2D Metal‐Porphyrin Frameworks for Initiator‐Free, Broadband Photocatalytic Synthesis of Ultrahigh Molecular Weight Polymers
Authors: Gao Qiang , Wang Shiyu , Xie Yi , Chen Jing , Ye Gang 
Published: October 2024

AbstractMetal‐organic frameworks bearing coordinatively unsaturated metal sites (CUSs) exhibit distinctive interactions toward guest molecules, thereby presenting intriguing properties in photocatalytic applications. Herein, an adaptable strategy is established to create 2D metal‐porphyrin frameworks while engineering the CUSs based on the use of bivalent metal nodes (Zn2+, Co2+, Cu2+, Ni2+, Cd2+) and Zr‐O clusters. The strong surface‐coordination effect reduces the energy barriers to activate acrylate monomers adsorbed to the nanosheet frameworks, enabling the generation of anion radicals through a broadband light‐induced electron transfer pathway. Particularly, the photocatalytic cycle offers a hole‐mediated deactivation mechanism to regulate the radical concentrations in the polymerization system, while the propagating chains exhibit a surface‐confined growth behavior that significantly inhibits recombination terminations. Extensive mechanistic studies and theoretical calculations reveal the molecular‐level guest‐framework interactions and establish the guidelines to screen metal centers for fabricating valid photocatalysts and monomers compatible with photo‐regulated polymerization. A series of ultrahigh molecular weight polymers with Mn > 1 000 000 and relatively low dispersity (Đ ≈ 1.5) are obtained upon exposure to the full spectrum of visible light. This study provides novel inspirations for harnessing natural sunlight to drive macromolecular synthesis with minimal energy consumption.
Synergistic Effect of H+ and I− Oxidation Enables Long‐Term Stability of the Precursor Solutions and Enhanced Performance of FA‐Dominated Perovskite Solar Cells
Authors: Yin Song , Jiao Xuewei , Liu Xudong , Liu Mingxuan , Xu Bingshun , Li Na , Lu Yonghao , Yang Shaopeng , Kong Weiguang 
Published: October 2024

AbstractThe role of MA in FAMA mixed perovskite remains far from being fully understood, due to the intricate chemical evolutions in the precursor solutions. Adjusting the content of MA in FAMA mixed perovskite arbitrarily remains a great challenge. This study elucidates a synergistic effect between H+ and I− oxidation which helps to reduce the content of MA in FA‐dominated perovskite. Briefly, excessive H+ boosts the balanced and rapid assembly of MA and FA components in FA‐dominated perovskite and hampers unfavorable chemical evolution induced by nucleophilic reaction between MA and FA in the precursor solution, while I− oxidation accelerates the in situ crystallization of perovskite. Leveraging this synergistic effect, centimeter‐scaled FAxMA(1‐x)PbI3 single crystals with arbitrarily adjustable values of x are successfully fabricated. In addition, peroxyacetic acid is introduced as the additive, enabling the blade‐coated FA0.9MA0.1PbI3 perovskite solar cells (PSCs) to achieve an impressive efficiency of 23.7%. The efficiency achieved here is among the highest values for blade‐coated PSCs with FA content exceeding 90% so far. The optimized solution developed in this study achieved exceptional stability, allowing it to be stored under air conditions for over 2 months without significant degradation in cell efficiency. This outcome satisfies the requirements for commercialization.
Enhanced Pyroelectricity Over Extended Thermal Range in Flexible Polymer Thin Films
Authors: Xie Kaili , Housseini Joulia , Resende Pedro M. , Le Goupil Florian , Isasa Jean‐David , Tencé‐Girault Sylvie , Fleury Guillaume , Kellay Hamid , Hadziioannou Georges 
Published: October 2024

AbstractPolymer‐based pyroelectric thin films are crucial functional materials at the core of flexible and lightweight electronic devices, such as wearable monitoring sensors, energy harvesters, and infrared detectors. Nevertheless, the pyroelectric properties of the polymer films, such as poly(vinylidene fluoride‐trifluoroethylene) (P(VDF‐TrFE)), vanish when the surrounding temperature exceeds the ferroelectric‐to‐paraelectric transition temperature, and thus limits their pyroelectric performance to a low‐temperature range. Herein, to mitigate this issue by employing a new class of P(VDF‐TrFE) copolymer which has a low TrFE molar content is proposed. Fine‐tuning of the structure through thermal annealing in a vacuum environment significantly favors robust and highly polarized polymer films with a large area. Electric poling combined with an optimal annealing temperature (110–120 °C) gives highly ordered ferroelectric crystalline domains in the polymer films. Consequently, this remarkably broadens the temperature range (roughly up to 140 °C) for which the polymer film still presents high pyroelectric properties (pyroelectric coefficient 50 µC (m2K)−1). This study provides an alternative choice for pyroelectric polymer films with enhanced pyroelectricity in applications that require wider temperature ranges.
High‐Throughput Screening of High‐Performance Magnetocaloric Materials by Gradient Additive Manufacturing
Authors: Xie Longlong , Liang Chenguang , Qin Yazhou , Zhou He , Yu Ziyuan , Chen Haodong , Naeem Muhammad Zeeshan , Qiao Kaiming , Wen Yaojie , Zhang Baicheng , Wang Gaofeng , Li Xiao , Liu Jian , Franco Victorino , Chu Ke , Yi Min , Zhang Hu 
Published: October 2024

AbstractMagnetic refrigeration based on magnetocaloric effect (MCE) has become a promising cooling technology to replace the traditional vapor compression refrigeration. However, traditional methods for searching MCE materials require producing many different compositions, causing unbearable workload and long experimental periods. Here, 3D printed La0.7Ce0.3Fe11.65Si1.35–Fe compositionally gradient alloys (CGAs) are successfully prepared using laser powder bed fusion equipped with a powder hopper with dual‐bin structure. This CGAs accelerate the high‐throughput screening for the best composition of La(Fe, Si)13/Fe with both high MCE and mechanical properties. The good interfacial compatibility between brittle 1:13 phase and reinforcing α‐Fe improves the mechanical properties significantly. Even after hydrogenation, the compressive strength and ultimate strain of the La(Fe, Si)13/Fe hydrides are ≈220% and ≈150% higher than those of stoichiometric La(Fe, Si)13. Meanwhile, the hydrogenated composite exhibits a large MCE under low magnetic field, e.g., the magnetic entropy change |ΔSM|max of 7.6 J kg−1 K−1 under 2 T is 52% higher than that of the benchmark Gd (5.0 J kg−1 K−1). Furthermore, this La(Fe, Si)13/Fe is 3D printed into various complex shapes suitable for heat exchangers. This study provides an innovative strategy for high‐throughput screening of new materials.
Halogenation Engineering of Solid Additives Enables 19.39% Efficiency and Stable Binary Organic Solar Cells via Manipulating Molecular Stacking and Aggregation of Both Donor and Acceptor Components
Authors: Su Wenyan , Zhou Xuming , Wu Qiang , Wu Yue , Qin Hongmei , Liang Zezhou , Li Hongxiang , Bai Hairui , Guo Jing , Jiang Long , Liu Yuhang , Ma Ruijie , Li Yuxiang , Zhu Weiguo , Fan Qunping 
Published: October 2024

AbstractBy selectively interacting with acceptor components, various typed solid additives achieve boosted power conversion efficiency (PCE) in organic solar cells (OSCs). However, due to the efficient active layer being composed of donor and acceptor materials, it is difficult to obtain the desired morphology by manipulating the acceptor component alone, limiting further improvement of PCEs. Herein, two solid additives with a same backbone of thiophene‐benzene‐thiophene (halogen‐free D1‐H) but different halogen substituents (fluorinated D1‐F and chlorinated D1‐Cl) are developed to probe the working mechanism of halogenated variation of solid additives in OSCs. Unlike D1‐H with continuous charge distributions, D1‐F and D1‐Cl show isolated positive charge distribution in benzene‐core and negative charge distribution in thiophene, offering stronger non‐covalent interactions with both donor (PM6) and acceptor (L8‐BO), especially D1‐Cl. Consequently, D1‐Cl‐treated active layer obtains an optimized phase separation and improved molecular packing, boosting PCE to 18.59% and device stability of OSCs, with 17.62% for D1‐H‐treated counterparts. Moreover, using D18:L8‐BO and D18:BTP‐eC9 as active layers, D1‐Cl‐treated binary OSCs obtain impressive PCEs of 19.29% and 19.39%, respectively. This work indicates that halogenation engineering developed in solid additives can effectively regulate morphology for improving PCE and stability of OSCs, and elucidates the underlying mechanism.
Dismountable Protein Corona‐Modified Virus‐Like Manganese‐Arsenic Nanomedicine Enables Safe and Targeted Delivery for Synergistic Arsenotherapy
Authors: Tian Haina , Gao Xiaoyang , Wei Haiyun , Ding Zongyao , Ming Qian , Wu Weiwei , Zhang Xiao , Ren Shuaiwei , Li Zhaowei , Shao Fengying , Wang Changlong 
Published: October 2024

AbstractArsenic agents have shown great potential in fighting leukemia, but are poorly known in treating solid tumors, mainly ascribing to the rapid clearance and low targeting ability. It is reported that morphology modulation can enhance the interaction between nanoparticles and cell membrane. Herein, a dismountable protein corona‐modified virus‐like manganese‐arsenic nanomedicine (vMnAs@HR) is rationally proposed for realizing safe and targeted delivery and synergistic arsenotherapy. The virus‐like manganese‐arsenic nanoparticle (vMnAs) is constructed followed by modification of a temporary R848‐loaded HDL (HR) protein corona. Upon intravenous injection, the HR protein corona is stable and actively targeted to tumor tissue by taking advantage of the interaction between HDL and its receptor SR‐BI. Intriguingly, upon accumulated in the tumor, HR can be jettisoned and interacted with macrophages for proinflammatory phenotype modulation. The re‐exposed vMnAs can efficiently enhance endocytosis by taking advantage of the rationally designed spiky morphology. Moreover, the released double‐stranded DNA (dsDNA) and manganese ions during tumor cell apoptosis can cooperatively activate cyclic guanosine monophosphate adenosine monophosphate synthase (cGAS)‐stimulator of interferon genes (STING) signaling pathway of DCs for systematic immune activation. It is anticipated that this morphology‐transformable nanomedicine can realize safe and efficient arsenic delivery for synergistic arsenotherapy.
Concentration‐Switchable Assembly of Carbon Dots for Circularly Polarized Luminescent Amplification in Chiral Logic Gates and Deep‐Red Light‐Emitting Diodes
Authors: Ai Lin , Wang Haolin , Wang Boyang , Liu Suya , Song Haoqiang , Lu Siyu 
Published: October 2024

AbstractStimuli‐responsive circularly polarized luminescent (CPL) materials are expected to find widespread application in advanced information technologies, such as 3D displays, multilevel encryption, and chiral optical devices. Here, using R‐/S‐α‐phenylethylamine and 3,4,9,10‐perylenetetracarboxylic dianhydride as precursors, chiral carbon dots (Ch‐CDs) exhibiting bright concentration‐dependent luminescence are synthesized, demonstrating reversible responses in both their morphologies and emission spectra. By adjusting Ch‐CD concentration, the switchable wavelength is extended over 180 nm (539–720 nm), with the maximum quantum efficiency reaching 100%. Meanwhile, upon increasing Ch‐CD concentration, the emission wavelength red‐shifts, while the chirality of the assembled nanoribbons is synchronously amplified, ultimately achieving CPL at 709 nm and a maximum luminescence asymmetry factor of 2.18 × 10−2. These values represent the longest wavelength and the largest glum reported for CDs. Considering the remarkable optical properties of the synthesized Ch‐CDs, multilevel chiral logic gates are designed, and their potential practical applications are demonstrated in multilevel anti‐counterfeiting encryption, flexible electronic printing, and solid‐state CPL. Furthermore, deep‐red chiral electroluminescence light‐emitting diodes (EL‐LEDs) are prepared using these Ch‐CDs, achieving an external quantum efficiency of 1.98%, which is the highest value reported to date for CDs in deep‐red EL‐LEDs, and the first report of chiral electronic devices based on CDs.
A Mg Battery‐Integrated Bioelectronic Patch Provides Efficient Electrochemical Stimulations for Wound Healing
Authors: Ma Xuenan , Zhou Yan , Xin Meiying , Yuan Hongming , Chao Danming , Liu Fangmeng , Jia Xiaoteng , Sun Peng , Wang Caiyun , Lu Geyu , Wallace Gordon 
Published: October 2024

AbstractBioelectronic patches hold promise for patient‐comfort wound healing providing simplified clinical operation. Currently, they face paramount challenges in establishing long‐term effective electronic interfaces with targeted cells and tissues due to the inconsistent energy output and high bio interface impedance. Here a new electrochemical stimulation technology is reported, using a simple wound patch, which integrates the efficient generation and delivery of stimulation. This is realized by employing a hydrogel bioelectronic interface as an active component in an integrated power source (i.e., Mg battery). The Mg battery enhances fibroblast functions (proliferation, migration, and growth factor secretion) and regulates macrophage phenotype (promoting regenerative polarization and down‐regulating pro‐inflammatory cytokines), by providing an electric field and the ability to control the cellular microenvironment through chemical release. This bioelectronic patch shows an effective and accelerated wound closure by guiding epithelial migration, mediating immune response, and promoting vasculogenesis. This new electrochemical‐mediated therapy may provide a new avenue for user‐friendly wound management as well as a platform for fundamental insights into cell stimulation.
Infrared Photodetectors: Recent Advances and Challenges Toward Innovation for Image Sensing Applications
Authors: Saleem Muhammad Imran , Kyaw Aung Ko Ko , Hur Jaehyun 
Published: October 2024

AbstractHigh‐resolution infrared (IR) imaging technology holds substantial significance across diverse fields including biomedical imaging, environmental surveillance, and IR digital cameras. Current IR detectors used in commercial applications are based on ultra‐high vacuum‐processed traditional inorganic semiconductors like silicon or III‐V compounds (e.g., Si, Ge, and InGaAs). However, the rapid advancements in applications such as autonomous vehicles, virtual reality, and point‐of‐care healthcare are driving an escalating need for innovative imaging technologies. This review aims to bridge the gap by exploring solution‐processed semiconductor photodetectors (PDs), which offer distinct advantages including cost‐effectiveness, tunable spectral response, and potential for multiple‐exciton generation. These characteristics make them particularly suitable for optical communication, IR imaging, and biological monitoring applications. This review provides comprehensive insights into the research trends pertaining to solution‐processed IR detectors and imagers based on colloidal quantum dots, perovskites, organic compounds, and 2D materials. The review commences with the current market worth of image sensors, the fundamental principles of single‐pixel and multipixel array IR imagers, and key parameters used to assess IR detector performance. In essence, the review concludes with a summary of recent advancements and future prospects for next‐generation IR PD devices and their potential application as an IR imager.
Direct Photo‐Crosslinking Patterning for High‐Performance 0D–2D Hybrid Photodetectors
Authors: Kim Jung‐Min , Jeong Seock‐Jin , Kim Hae‐Sik , Kim Do‐Eok , Yu Jeong Hwan , Lee Sang‐Hyeon , Ahn Jae‐Hyeon , Cho Sinyoung , Chae Weon‐Sik , Lee Jong‐Soo 
Published: October 2024

AbstractHigh‐performance 0D–2D hybrid photodetectors integrated with a crosslinker for direct pattering of quantum dots on the large‐scale synthesized MoS2 layer are reported. In the patterned hybrid structure, QD layers are patterned with a resolution of up to 2 µm, ensuring high precision. Enhanced charge transfer from QDs to 2D materials is confirmed using PL quenching, TR‐PL, and UPS analysis. As a result, the QD/2D hybrid photodetectors with crosslinker‐assisted direct patterning demonstrated a remarkable photoresponsivity of ≈105 A W−1 and a specific detectivity of over 1011 Jones, attributed to the difference in built‐in potential. The crosslinker patterning of QDs opens up potential applications for the photodetectors in highly integrated image sensors and can be further extended to high‐resolution display industries, eliminating unnecessary fabrication processes.
Combinatory Immunotherapy for Glioblastoma Treatment
Authors: Ijaz Muhammad , Hasan Ikram , Jiang Zhiru , Ullah Zia , Aslam Bilal , Khurshid Mohsin , Sun Yansun , Guo Bing 
Published: October 2024

AbstractDespite advancements in the treatment of glioblastoma, it faces challenges due to tumor heterogeneity, the blood‐brain barrier, recurrence, immune evasion, and conventional strategies, leading to low survival and a poor prognosis. Therefore, it is crucial to develop novel, useful treatment strategies for improving brain distribution to overcome blood‐brain barriers (BBB) and help the treatment of glioblastoma. Conventional immunotherapy like checkpoint inhibitors, CAR‐T cell therapy, monoclonal antibodies, cancer vaccines, and adoptive cell transfer often suffers from low therapeutic outcomes because the singular therapy generally has shortcomings, such as the cold immune microenvironment of brain tumors. In contrast, the emerging combinatory immunotherapy integrated with chemo‐immunotherapy, photothermal‐immunotherapy, and radio‐immunotherapy has shown great promise to modulate tumoral immune microenvironment and boost treatment outcomes. This review discusses the immune microenvironment of GBM, its impact on immunological effects, current immunotherapy methods, and advanced studies. It also introduces combinational GBM immunotherapy with traditional cancer therapies like chemo‐immunotherapy, surgery‐immunotherapy, photothermal‐immunotherapy, and radiotherapy‐immunotherapy. In the future, it is anticipated that this article will provide beneficial information and a path for the strategy of innovative, efficient combination immunotherapy in the treatment of glioblastoma.
Overcoming Biopotency Barriers: Advanced Oral Delivery Strategies for Enhancing the Efficacy of Bioactive Food Ingredients
Authors: Liu Ling , McClements David Julian , Liu Xuebo , Liu Fuguo 
Published: October 2024

AbstractBioactive food ingredients contribute to the promotion and maintenance of human health and wellbeing. However, these functional ingredients often exhibit low biopotency after food processing or gastrointestinal transit. Well‐designed oral delivery systems can increase the ability of bioactive food ingredients to resist harsh environments inside and outside the human body, as well as allow for controlled or triggered release of bioactives to specific sites in the gastrointestinal tract or other tissues and organs. This review presents the characteristics of common bioactive food ingredients and then highlights the barriers to their biopotency. It also discusses various oral delivery strategies and carrier types that can be used to overcome these biopotency barriers, with a focus on recent advances in the field. Additionally, the advantages and disadvantages of different delivery strategies are highlighted. Finally, the current challenges facing the development of food‐grade oral delivery systems are addressed, and areas where future research can lead to new advances and industrial applications of these systems are proposed.