bluuebunny/crossref_metadata_2025_split huggingface dataset:
Operating strategies for acid phase digestion: an industrial case study
Authors: Gomes Vincent G. , Rabines Mayra , Bustamante Heri 
Published: August 2016

AbstractAcid phase digestion was investigated for enhanced operation in an industrial wastewater treatment plant. In particular, sludge retention time (SRT), temperature and pH were assessed for determining optimal conditions under operating constraints. Volatile fatty acid (VFA) production and soluble chemical oxygen demand (SCOD) were the key process parameters used to assess system performance. Increase in SRT from 0.8 to 1.4 days (at 22°C) had moderate effect on VFA production (approximately 15% increase), achieving a maximum VFA production of 3600 mg/L. High VFA production rate (0.101 ± 0.035 mg/mgVS.d) was obtained at the highest operating retention time during summer (27°C). The degree of solubilisation of particulate organic matter increased with temperature and retention time. Despite an increase in SCOD (6472 ± 873 mg/L max.), a corresponding increase in VFA was not observed. SCOD showed a linear correlation with decrease in pH, while acidogenesis (SCOD conversion to VFA) was found to be favourable at a pH of 4.5.
An approach to investigate the costs of herbicide‐resistant Alopecurus myosuroides
Authors: Gerhards R , Dentler J , Gutjahr C , Auburger S , Bahrs E 
Published: August 2016

SummaryHerbicide resistance in Alopecurus myosuroides causes severe problems in Western European cropping systems. Costs of herbicide resistance were investigated in this study by analysing variable production costs and sales revenues. Three farms were selected for this study, with winter wheat as the dominating crop in all farms. Resistance in A. myosuroides populations was verified at all locations. Four farming approaches were simulated over a period of 20 years: (i) continuing the actual cropping system without increase of resistance, (ii) continuing the actual cropping system with increase of resistance, (iii) changing cropping practice to overcome resistance and (iv) changing cropping practice to prevent resistance. Contribution margins representing the proportion of sales revenue that is not consumed by variable costs were calculated for all approaches. Comparative static simulations showed that average contribution margins in a cropping system with more than 60% winter cereals and reduced tillage practice dropped from 807 € ha−1 a−1 without herbicide resistance to 307 € ha−1 a−1 with herbicide resistance. Alopecurus myosuroides population densities increased to more than 1000 plants m−2. Diverse crop rotations, including spring crops, clover–grass leys and intensive tillage, suppressed A. myosuroides populations, and average contribution margin was 630 € ha−1 a−1. Preventive methods with rotations of winter cereals and spring crops with less clover–grass leys resulted in an average contribution margin of 691 € ha−1 a−1. In conclusion, rotations of winter cereals and spring crops combined with inversion tillage and herbicides provide stable yields and can prevent weed population increase.
Draft Genome Sequence of
Aeromonas dhakensis
Strain F2S2-1, Isolated from the Skin Surface of an Indian Oil Sardine (
Sardinella longiceps
)
Authors: Nadiga Mohan , Vaidyanathan V. V. , Thayumanavan Thangavelu 
Published: August 2016

ABSTRACT

Draft genome sequencing of
Aeromonas dhakensis
strain F2S2-1, isolated from the skin surface of an Indian oil sardine (
Sardinella
longiceps), has been carried out. The draft genome was roughly 4.7 Mb in size with 61.7% G+C content. Annotation of the genome yielded 4,337 genes coding for proteins, tRNAs, and rRNAs. Annotation also revealed the presence of 52 genes linked to resistance to antibiotics/toxic compounds. Pathway analysis revealed the presence of novobiocin biosynthetic genes and genes for biosynthesis of a siderophore group on nonsynthetic peptides.
Draft Genome Sequence of
Aeromonas
sp. Strain EERV15
Authors: Ehsani Elham , Barrantes Israel , Vandermaesen Johanna , Geffers Robert , Jarek Michael , Boon Nico , Springael Dirk , Pieper Dietmar H. , Vilchez-Vargas Ramiro 
Published: August 2016

ABSTRACT

We report here the draft genome sequence of
Aeromonas
sp. strain EERV15 isolated from sand filter. The organism most closely related to
Aeromonas
sp. EERV15 is
Aeromonas veronii
B565, with an average 83% amino acid sequence similarity of putatively encoded protein open reading frames.
Evaluation of statin prescriptions in type 2 diabetes: India Heart Watch-2
Authors: Gupta Rajeev , Lodha Sailesh , Sharma Krishna K , Sharma Surendra K , Gupta Sunil , Asirvatham Arthur J , Mahanta Bhupendra N , Maheshwari Anuj , Sharma Dinesh C , Meenawat Anand S , Khedar Raghubir S 
Published: August 2016

BackgroundContemporary treatment guidelines advise statin use in all patients with diabetes for reducing coronary risk. Use of statins in patients with type 2 diabetes has not been reported from India.MethodsWe performed a multisite (n=9) registry-based study among internists (n=3), diabetologists (n=3), and endocrinologists (n=3) across India to determine prescriptions of statins in patients with type 2 diabetes. Demographic and clinical details were obtained and prescriptions were audited for various medications with a focus on statins. Details of type of statin and dosage form (low, moderate, and high) were obtained. Patients were divided into categories based on presence of cardiovascular risk into low (no risk factors, n=1506), medium (≥1 risk factor, n=5425), and high (with vascular disease, n=1769). Descriptive statistics are presented.ResultsPrescription details were available in 8699 (men 5292, women 3407). Statins were prescribed in 55.2% and fibrates in 9.2%. Statin prescription was significantly greater among diabetologists (64.4%) compared with internists (n=53.3%) and endocrinologists (46.8%; p<0.001). Atorvastatin was prescribed in 74.1%, rosuvastatin in 29.2%, and others in 3.0%. Statin prescriptions were lower in women (52.1%) versus men (57.2%; p<0.001) and in patients aged <40 years (34.3%), versus those aged 40–49 (49.7%), 50–59 (60.1%), and ≥60 years (62.2%; p<0.001). Low-dose statins were prescribed in 1.9%, moderate dose in 85.4%, and high dose in 12.7%. Statin prescriptions were greater in the high-risk group (58.0%) compared with those in the medium-risk (53.8%) and low-risk (56.8%) groups (p <0.001). High-dose statin prescriptions were similar in the high-risk (14.5%), medium-risk (11.8%), and low-risk (13.5%) groups (p=0.31).ConclusionsStatins are prescribed in only half of the clinic-based patients in India with type 2 diabetes. Prescription of high-dose statins is very low.
Severity and pattern of injuries caused by the traditional Swiss team sport ‘Hornussen’: first retrospective study at a level I trauma centre in Switzerland
Authors: Waterkamp Volkmar , Ricklin Meret , Schaller Benoît , Katsoulis Konstantinos , Exadaktylos Aristomenis 
Published: August 2016

BackgroundThis article addresses typical injury patterns related to the traditional Swiss team sport of Hornussen. A small plastic disk is struck with a special elastic racket and then intercepted in the field. Severe injuries have occasionally been reported. We present a systematic review of all cases of Hornussen injuries treated in the University Hospital of Bern from 2000 to 2014.MethodsTo assess the frequency, type and outcome of Hornussen injuries, we performed a database search of all inpatient and outpatient cases related to Hornussen and that were admitted to and/or treated in Bern University Hospital from 2000 to 2014.ResultsA total of 28 such patients could be identified. Apart from 1 woman injured as a bystander and treated as an outpatient, all patients were male and active players. Typical injury patterns comprised midfacial fractures and severe ocular traumata, very often in combination. Almost all of these patients had to be hospitalised due to the severity of the trauma suffered and underwent surgery. 1 patient had to be admitted to the intensive care unit prior to the operation.ConclusionsEye and face injuries caused by Hornussen can be devastating. This resembles the potential risk of other bat-and-ball sports, such as cricket and baseball. Apart from the economic loss due to treatment costs and sick leave, these injuries can be disabling for life. It should therefore be mandatory for all players to wear protective gear, as is already the case for Hornussen players born in 1984 or later.
The effect of Cd substitution doping on the bandgap and absorption spectrum of ZnO
Authors: Hou Qingyu , Li Yong , Qu Lingfeng , Zhao Chunwang 
Published: August 2016

Many research papers have reported that in the ultraviolet area of 290–360 nm wavelength range, blueshift and redshift in the absorption spectrum occurred in ZnO with Cd doping; however, there is no reasonable theoretical explanation to this so far. To solve this problem, this study investigates the differences of blueshift and redshift in doping system by adopting plane-wave ultrasoft pseudopotential technology based on the density functional theory and applying [Formula: see text] method to calculate band structures, density of states and absorption spectrum distribution of the models, which is on the basis of model geometry optimization. By increasing the Cd doping concentration, the following results are obtained: increased volume of the mixed system, raised total energy, a decrease in stability, narrowed bandgaps and a significant redshift in the absorption spectrum in the ultraviolet or visible light area.
The Novel Tubulin-Binding Checkpoint Activator BAL101553 Inhibits EB1-Dependent Migration and Invasion and Promotes Differentiation of Glioblastoma Stem-like Cells
Authors: Bergès Raphaël , Tchoghandjian Aurélie , Honoré Stéphane , Estève Marie-Anne , Figarella-Branger Dominique , Bachmann Felix , Lane Heidi A. , Braguer Diane 
Published: August 2016

AbstractGlioblastoma patients have limited treatment options. Cancer stem-like cells (CSLC) contribute to glioblastoma invasiveness and repopulation; hence, they represent promising targets for novel therapies. BAL101553 is a prodrug of BAL27862, a novel microtubule-destabilizing agent inhibiting tumor cell proliferation through activation of the spindle assembly checkpoint, which is currently in phase I/II clinical development. Broad anticancer activity has been demonstrated against human cancer models, including tumors refractory to conventional treatments. We have shown that overexpression of microtubule + end-binding 1-protein (EB1) correlates with glioblastoma progression and poor survival. Here, we show that BAL27862 inhibits the growth of two glioblastoma CSLCs. As EB1 is overexpressed in the CSLC line GBM6, which displays a high tumorigenicity and infiltrative pattern of migration in vivo, we investigated drug activity on GBM6 according to EB1 expression. BAL27862 inhibited migration and colony formation at subcytotoxic concentrations in EB1-expressing control cells (GBM6-sh0) but only at cytotoxic concentrations in EB1-downregulated (GBM-shE1) cells. Three administrations of BAL101553 were sufficient to provoke an EB1-dependent survival benefit in tumor-bearing mice. Patterns of invasion and quantification of tumor cells in brain demonstrated that GBM6-sh0 cells were more invasive than GBM6-shEB1 cells, and that the antiproliferative and anti-invasive effects of BAL101553 were more potent in mice bearing control tumors than in EB1-downregulated tumors. This was associated with inhibition of stem cell properties in the GBM6-sh0 model. Finally, BAL27862 triggered astrocytic differentiation of GBM6 in an EB1-dependent manner. These results support the potential of BAL101553 for glioblastoma treatment, with EB1 expression as a predictive biomarker of response. Mol Cancer Ther; 15(11); 2740–9. ©2016 AACR.
Real-world comparison of major bleeding risk among non-valvular atrial fibrillation patients initiated on apixaban, dabigatran, rivaroxaban, or warfarin
Authors: Keshishian Allison , Kamble Shital , Pan Xianying , Mardekian Jack , Horblyuk Ruslan , Hamilton Melissa , Lip Gregory Y. H. 
Published: August 2016

SummaryIn addition to warfarin, there are four non-vitamin K antagonist oral anticoagulants (NOACs) available for stroke prevention in non valvular atrial fibrillation (NVAF). There are limited data on the comparative risks of major bleeding among newly anticoagulated NVAF patients who initiate warfarin, apixaban, dabigatran, or rivaroxaban, when used in ‘real world’ clinical practice. The study used the Truven MarketScan® Commercial & Medicare supplemental US claims database. NVAF patients aged ≥18 years newly prescribed an oral anticoagulant 01JAN2013–31DEC2014, with a ≥1-year baseline period, were included (study period: 01JAN2012–31DEC2014). Major bleeding was defined as bleeding requiring hospitalisation. Propensity score matching (PSM) was used to balance age, sex, region, baseline comorbidities, and comedications. Cox proportional hazards models were used to estimate the PSM hazard ratio (HR) of major bleeding. Among 45,361 newly anticoagulated NVAF patients, 15,461 (34.1 %) initiated warfarin, 7,438 (16.4 %) initiated apixaban, 17,801 (39.2 %) initiated rivaroxaban, and 4,661 (10.3 %) initiated dabigatran. Compared to matched warfarin initiators, apixaban (HR: 0.53; 95 % CI: 0.39–0.71) and dabigatran (HR: 0.69; 95 % CI: 0.50–0.96) initiators had a significantly lower risk of major bleeding. Patients initiating rivaroxaban (HR: 0.98; 95 % CI: 0.83–1.17) had a non-significant difference in major bleeding risk compared to matched warfarin patients. When comparisons were made between NOACs, matched rivaroxaban patients had a significantly higher risk of major bleeding (HR: 1.82; 95 % CI: 1.36–2.43) compared to apixaban patients. The differences for apixaban-dabigatran and dabigatran-rivaroxaban matched cohorts were not statistically significant. Among newly anticoagulated NVAF patients in the real-world setting, apixaban and dabigatran initiation was associated with significantly lower risk of major bleeding compared to warfarin initiation. When compared to apixaban, rivaroxaban initiation was associated with significantly higher risk of major bleeding.Note: The review process for this paper was fully handled by Christian Weber, Editor in Chief.Supplementary Material to this article is available online at www.thrombosis-online.com.
Diastolic Backward-Traveling Decompression (Suction) Wave Correlates With Simultaneously Acquired Indices of Diastolic Function and Is Reduced in Left Ventricular Stunning
Authors: Ladwiniec Andrew , White Paul A. , Nijjer Sukhjinder S. , O’Sullivan Michael , West Nick E.J. , Davies Justin E. , Hoole Stephen P. 
Published: August 2016

Background—
Wave intensity analysis can distinguish proximal (propulsion) and distal (suction) influences on coronary blood flow and is purported to reflect myocardial performance and microvascular function. Quantifying the amplitude of the peak, backwards expansion wave (BEW) may have clinical utility. However, simultaneously acquired wave intensity analysis and left ventricular (LV) pressure–volume loop data, confirming the origin and effect of myocardial function on the BEW in humans, have not been previously reported.

Methods and Results—

Patients with single-vessel left anterior descending coronary disease and normal ventricular function (n=13) were recruited prospectively. We simultaneously measured LV function with a conductance catheter and derived wave intensity analysis using a pressure–low velocity guidewire at baseline and again 30 minutes after a 1-minute coronary balloon occlusion. The peak BEW correlated with the indices of diastolic LV function: LV dP/dt
min
(
r

s

=−0.59;
P
=0.002) and τ (
r

s

=−0.59;
P
=0.002), but not with systolic function. In 12 patients with paired measurements 30 minutes post balloon occlusion, LV dP/dt
max
decreased from 1437.1±163.9 to 1299.4±152.9 mm Hg/s (median difference, −110.4 [−183.3 to −70.4];
P
=0.015) and τ increased from 48.3±7.4 to 52.4±7.9 ms (difference, 4.1 [1.3–6.9];
P
=0.01), but basal average peak coronary flow velocity was unchanged, indicating LV stunning post balloon occlusion. However, the peak BEW amplitude decreased from −9.95±5.45 W·m
–2
/s
2
×10
5
to −7.52±5.00 W·m
–2
/s
2
×10
5
(difference 2.43×10
5
[0.20×10
5
to 4.67×10
5
;
P
=0.04]).

Conclusions—
Peak BEW assessed by coronary wave intensity analysis correlates with invasive indices of LV diastolic function and mirrors changes in LV diastolic function confirming the origin of the suction wave. This may have implications for physiological lesion assessment after percutaneous coronary intervention.

Clinical Trial Registration—

URL:
http://www.isrctn.org
. Unique identifier: ISRCTN42864201.
Prevalence of Amyloid Positron Emission Tomographic Positivity in Poststroke Mild Cognitive Impairment
Authors: Wollenweber Frank Arne , Därr Sonja , Müller Claudia , Duering Marco , Buerger Katharina , Zietemann Vera , Malik Rainer , Brendel Matthias , Ertl-Wagner Birgit , Bartenstein Peter , Rominger Axel , Dichgans Martin 
Published: August 2016

Background and Purpose—
Mild cognitive impairment (MCI) is common after stroke and associated with poor outcome. However, the mechanisms underlying poststroke MCI (PS-MCI) are insufficiently understood. We performed amyloid-β positron emission tomography (PET) in a prospective cohort of stroke survivors to determine the role of amyloid pathology in PS-MCI.

Methods—

We studied 178 consecutive patients enrolled into the prospective DEDEMAS study (Determinants of Dementia After Stroke). Follow-up visits 6 months post stroke included detailed cognitive testing, standardized magnetic resonance imaging, and amyloid-β imaging using flutemetamol (
18
F) PET. MCI was defined by the modified Petersen criteria. Amyloid-positivity was assessed visually and quantitatively. Fifty-six (31%) patients agreed to undergo PET imaging.

Results—

Thirty-eight (68%) patients who consented to PET imaging had PS-MCI. Visual assessment revealed amyloid PET positivity in 2 (5%) of the 38 PS-MCI patients and in 2 (11%) of the 18 cognitively healthy stroke survivors. There was no correlation between flutemetamol (
18
F) standardized uptake value ratios and cognitive scores in the 56 patients. PS-MCI patients had significant cognitive impairments on executive function (
P
<0.01) and memory tests (
P
<0.01) when compared with cognitively healthy stroke survivors (
P
<0.01).

Conclusions—
The prevalence of amyloid-pathology in patients with PS-MCI is not increased when compared with cognitively healthy stroke survivors and to recent estimates for cognitively healthy elderly subjects. Factors other than amyloid-pathology likely contribute to the development of PS-MCI.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01334749.
U-shaped curve of psychosis according to cannabis use: New evidence from a snowball sample
Authors: Brañas Antía , Barrigón María L , Garrido-Torres Nathalia , Perona-Garcelán Salvador , Rodriguez-Testal Juan F , Lahera Guillermo , Ruiz-Veguilla Miguel 
Published: August 2016

Background: The aim of this study was to investigate the relationship between psychotic-like experiences (PLEs) assessed using the Community Assessment of Psychic Experience (CAPE) questionnaire and the pattern of cannabis use in a non-clinical sample collected by snowball sampling. Methods: Our sample was composed of 204 subjects, distributed into three groups by their cannabis use pattern: 68 were non-cannabis users, 40 were moderate cannabis users and 96 were daily cannabis users. We assessed the psychotic experiences in each group with the CAPE questionnaire; and then controlled for the effect of possible confounding factors like sex, age, social exclusion, age of onset of cannabis use, alcohol use and other drug use. Results: We found a significant quadratic association between the frequency of cannabis use and positive (β = −1.8; p = 0.004) and negative dimension scores (β = −1.2; p = 0.04). The first-rank and mania factors showed a significant quadratic association ( p < 0.05), while the voices factor showed a trend ( p = 0.07). Scores for the different groups tended to maintain a U-shape in their values for the different factors. When we adjusted for gender, age, social exclusion, age of onset of cannabis use, and use of alcohol and other drugs, only the first-rank experiences remained significant. Conclusions: We found there was a U-shaped curve in the association between cannabis use and the positive and negative dimensions of the CAPE score. We also found this association in mania and first-rank experiences.
Understanding retirement for ageing adults with a disability in supported employment
Authors: Goods Naomi , Millsteed Jeannine 
Published: August 2016

Introduction Employees with disabilities in supported employment are ageing and, as their retirement from work approaches, it is critical to consider how they perceive their occupational roles might change. They need to consider what activities they choose to engage in, and what service or supports might be necessary to make a successful transition to retirement. The aim of this study was to understand how ageing employees with disabilities perceive retirement, and how their occupational roles might change. Method A qualitative study was conducted with 10 participants working in a supported employment service, for whom transitioning from work to retirement was imminent. Findings Participants perceived retirement to be boring, full of meaningless activities and lonely. It also meant a reduced income that would result in hardship, and a loss of self-esteem at losing their employee role. They had limited knowledge about alternative activities in retirement. Conclusion Participants perceived significant barriers to making the transition from employee to retiree. Occupational therapy can provide support with pre-retirement planning and evidence-based strategies such as a client-centred approach, mapping new routines, and training staff and mentors. They could also advocate for changes in service delivery to improve practices that will encourage active ageing for people with disabilities in retirement.
Spanish-Speaking Limited English Proficiency Patients and Call Light Use
Authors: Montie Mary , Galinato Jose Gabriel , Patak Lance , Titler Marita 
Published: August 2016

Introduction: Despite a continuous increase of the limited English proficiency (LEP) population in the United States, disparities in the quality of care received in health care systems persist. Method: This qualitative study explores the perceptions of hospitalized LEP patients on their call light use, as well as their perceptions of a prototype of a new multilingual call light system, Eloquence™. Individual interviews were conducted with 10 Spanish-speaking patient participants. Results: Using a constant comparative method, the following themes emerged: (1) reasons for call light use, (2) challenges with communication, (3) patients’ adaptation to language barriers, (4) perceived staff responses to call light, and (5) responses to the Eloquence™ demonstration. Conclusion: Data from this study shed light on the patient care experience of LEP patients and can help guide clinicians and administrators in providing culturally and linguistically competent care.