bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemical‐Bonding‐Directed Hierarchical Assembly of Nanoribbon‐Shaped Nanocomposites of Gold Nanorods and Poly(3‐hexylthiophene)
Authors: Pan Shuang , He Luze , Peng Juan , Qiu Feng , Lin Zhiqun 
Published: May 2016

AbstractNanoribbon‐shaped nanocomposites composed of conjugated polymer poly(3‐hexylthiophene) (P3HT) nanoribbons and plasmonic gold nanorods (AuNRs) were crafted by a co‐assembly of thiol‐terminated P3HT (P3HT‐SH) nanofibers with dodecanethiol‐coated AuNRs (AuNRs‐DDT). First, P3HT‐SH nanofibers were formed due to interchain π–π stacking. Upon the addition of AuNRs‐DDT, P3HT‐SH nanofibers were transformed into nanoribbons decorated with the aligned AuNRs on the surface (i.e., nanoribbon‐like P3HT/AuNRs nanocomposites). Depending on the surface coverage of the P3HT nanoribbons by AuNRs, these hierarchically assembled nanocomposites exhibited broadened and red‐shifted absorption bands of AuNRs in nIR region due to the plasmon coupling of adjacent aligned AuNRs and displayed quenched photoluminescence of P3HT. Such conjugated polymer/plasmonic nanorod nanocomposites may find applications in fields, such as building blocks for complex superstructures, optical biosensors, and optoelectronic devices.
Näherungsweise Traglastbestimmung von Mikropfählen
Authors: Schaller Gerhard , Jung Stefan 
Published: May 2016

AbstractMikropfähle bestehen in der Regel aus einem Rundstahlkern mit Betonumhüllung. Sie werden bei Gründungen und Gründungsergänzungen unter beengten Verhältnissen wie z. B. in Kellerräumen mit üblicher Geschosshöhe verwandt. In Fällen, in denen das durchörterte Erdreich eine weichere Konsistenz aufweist, besteht u. U. „Knickgefahr”, die besonderer Überlegungen bei der Festlegung der Tragfähigkeit bedarf. Hierauf wird im Folgenden eingegangen. Aufgrund der vergleichsweise einfachen Ansätze ist eine „Handrechnung” – zweckmäßigerweise unter Zuhilfenahme eines Tabellenkalkulationsprogramms – möglich. Dadurch erhöht sich die Transparenz der Berechnung.
Qualitative and quantitative analysis of the chemical constituents in Mahuang‐Fuzi‐Xixin decoction based on high performance liquid chromatography combined with time‐of‐flight mass spectrometry and triple quadrupole mass spectrometers
Authors: Sun Qihui , Cao Hongjie , Zhou Yanyan , Wang Xu , Jiang Haiqiang , Gong Lili , Yang Yong , Rong Rong 
Published: May 2016

AbstractHigh‐performance liquid chromatography coupled with time‐of‐flight mass spectrometry (HPLC‐TOF/MS) and high‐performance liquid chromatography–triple quadrupole mass spectrometry (HPLC‐QQQ/MS/MS) were utilized to clarify the chemical constituents of Mahuang‐Fuzi‐Xixin Decoction. There are 52 compounds, including alkaloids, amino acids and organic acids were identified or tentatively characterized by their characteristic high resolution mass data by HPLC‐QQQ/MS/MS. In the subsequent quantitative analysis, 10 constituents, including methyl ephedrine, aconine, songrine, fuziline, neoline, talatisamine, chasmanine, benzoylmesaconine, benzoylaconine and benzoylhypaconine were simultaneously determined by HPLC‐QQQ/MS/MS with multiple reaction monitoring mode. Satisfactory linearity was achieved with wide linear range and fine determination coefficient (r > 0.9992). The relative standard deviations (RSD) of inter‐ and intra‐day precisions were <3%. This method was also validated by repeatability, stability and recovery with RSD <3% respectively. A highly sensitive and efficient method was established for chemical constituents studying, including identification and quantification of Mahuang‐Fuzi‐Xixin decoction.
Open Cezeri Library: A novel java based matrix and computer vision framework
Authors: Ataş Musa 
Published: May 2016

ABSTRACTIn this paper we introduce the Open Cezeri Library (OCL) framework as a domain specific language (DSL) for researchers, scientists, and engineering students to enable them to develop basic linear algebra operations via simple matrix calculations, image processing, computer vision, and machine learning applications in JAVA programming language. OCL provides a strong intuition of coding for the developer while implementing by means of a fluent interface. The significant aspect of the OCL is to combine the methods of well‐known platforms; MATLAB and JAVA, accordingly. Moreover, OCL supports a fluent interface so that users can extend a single line of codes by putting a dot between the methods because all the methods implemented actually return the host class. It was observed that the learning curve of the OCL is lower than the MATLAB and the native JAVA languages, and makes coding more readable, understandable, traceable, and enjoyable. In addition to this, the experiments revealed that the running performance of the OCL is quite comparable and can be used in a variety of diverse applications. © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:736–743, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21745
Fascin‐1 as a novel diagnostic marker of triple‐negative breast cancer
Authors: Wang Chao‐Qun , Tang Chih‐Hsin , Chang Hao‐Teng , Li Xiao‐Ni , Zhao Yong‐Ming , Su Chen‐Ming , Hu Gui‐Nv , Zhang Tao , Sun Xin‐Xin , Zeng Yue , Du Zhang , Wang Yan , Huang Bi‐Fei 
Published: May 2016

AbstractIn some cases of breast cancer, diagnosis of triple‐negative breast cancer (TNBC) requires further fluorescence in situ hybridization (FISH) for determining human epidermal growth factor receptor 2 (HER2) status. However, few cases undergo FISH in China, leading to difficulty regarding subsequent treatment decisions. Here, we used immunohistochemical analysis to explore expression of fascin‐1, an actin‐bundling protein, as a diagnostic marker of TNBC. A total of 457 cases of breast cancer were divided into four molecular subtypes, including 82 cases (17.9%) of TNBC, 81 (17.7%) of HER2‐enriched, 185 (40.5%) of luminal A, and 109 (23.9%) of luminal B. Positive fascin‐1 expression was seen in 144 cases (31.5%), including 77 (16.8%) strong positive cases. Rates of positive and strong positive expression of fascin‐1 were significantly higher in cases of TNBC than in the other molecular subtypes. In all cases of breast cancer, the sensitivities and specificities of positive and strong positive fascin‐1 expression for predicting TNBC were 87.8% and 80.8%, and 78.0% and 96.5%, respectively. In cases of hormone receptor–negative breast cancer, the sensitivities and specificities of positive and strong positive fascin‐1 expression for predicting TNBC were 87.8% and 61.7%, and 78.0% and 92.6%, respectively. In 24 cases with estrogen receptor (ER)‐, PR‐, and HER2 2 + equivocal status who underwent FISH, the sensitivity and specificity of strong positive fascin‐1 expression for predicting TNBC were 71.4% and 90.0%. These results suggest that strong positive fascin‐1 expression can be used as a diagnostic marker of TNBC.
High expression of integrin β6 in association with the Rho–Rac pathway identifies a poor prognostic subgroup within HER2 amplified breast cancers
Authors: Desai Krisha , Nair Madhumathy G. , Prabhu Jyothi S. , Vinod Anupama , Korlimarla Aruna , Rajarajan Savitha , Aiyappa Radhika , Kaluve Rohini S. , Alexander Annie , Hari P. S. , Mukherjee Geetashree , Kumar Rekha V. , Manjunath Suraj , Correa Marjorrie , Srinath B. S. , Patil Shekhar , Prasad M. S. N. , Gopinath K. S. , Rao Raman N. , Violette Shelia M. , Weinreb Paul H. , Sridhar T. S. 
Published: May 2016

AbstractIntegrin αvβ6 is involved in the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) of the breast. In addition, integrin β6 (ITGB6) is of prognostic value in invasive breast cancers, particularly in HER2+ subtype. However, pathways mediating the activity of integrin αvβ6 in clinical progression of invasive breast cancers need further elucidation. We have examined human breast cancer specimens (N = 460) for the expression of integrin β6 (ITGB6) mRNA by qPCR. In addition, we have examined a subset (N = 147) for the expression of αvβ6 integrin by immunohistochemistry (IHC). The expression levels of members of Rho–Rac pathway including downstream genes (ACTR2, ACTR3) and effector proteinases (MMP9, MMP15) were estimated by qPCR in the HER2+ subset (N = 59). There is a significant increase in the mean expression of ITGB6 in HER2+ tumors compared to HR+HER2‐ and triple negative (TNBC) subtypes (P = 0.00). HER2+ tumors with the highest levels (top quartile) of ITGB6 have significantly elevated levels of all the genes of the Rho–Rac pathway (P‐values from 0.01 to 0.0001). Patients in this group have a significantly shorter disease‐free survival compared to the group with lower ITGB6 levels (HR = 2.9 (0.9–8.9), P = 0.05). The mean level of ITGB6 expression is increased further in lymph node‐positive tumors. The increased regional and distant metastasis observed in HER2+ tumors with high levels of ITGB6 might be mediated by the canonical Rho–Rac pathway through increased expression of MMP9 and MMP15.
An examination of racial differences in 5‐year survival of cervical cancer among African American and white American women in the southeastern US from 1985 to 2010
Authors: Weragoda Janaka , Azuero Andres , Badiga Suguna , Bell Walter C. , Matthews Roland , Piyathilake Chandrika 
Published: May 2016

AbstractDisparities in Cervical Cancer (CC) mortality outcomes between African American (AA) and White women have been studied for decades. However, conclusions about the effect of race on CC survival differ across studies. This study assessed differences in CC survival between AA and White women diagnosed between 1985 and 2010 and treated at two major hospitals in the southeastern US. The study sample included 925 AA and 1192 White women diagnosed with cervical adenocarcinoma, adenosquamous cell carcinoma, or squamous cell carcinoma. Propensity score adjustment and matching were employed to compare 5‐year survival between the two racial groups. Crude comparisons suggested relevant racial differences in survival. However, the racial differences became of small magnitude after propensity‐score adjustment and in matched analyses. Nonlinear models identified age at diagnosis, cancer stage, mode of treatment, and histological subtype as the most salient characteristics predicting 5‐year survival of CC, yet these characteristics were also associated with race. Crude racial differences in survival might be partly explained by underlying differences in the characteristics of racial groups, such as age at diagnosis, histological subtype, cancer stage, and the mode of treatment. The study results highlight the need to improve access to early screening and treatment opportunities for AA women to improve posttreatment survival from CC.
Percutaneous Transcatheter Treatment for Tricuspid Bioprosthesis Failure
Authors: Ruparelia Neil , Mangieri Antonio , Ancona Marco , Giannini Francesco , Agricola Eustachio , Montorfano Matteo , De Bonis Michele , Alfieri Ottavio , Colombo Antonio , Latib Azeem 
Published: May 2016

ObjectivesTo report procedural and 30‐day outcomes following percutaneous transcatheter valve‐in‐valve (VIV) implantation for tricuspid bioprosthesis failure, with a new generation balloon‐expandable transcatheter aortic valve implantation prosthesis.BackgroundSevere tricuspid regurgitation is associated with a reduction in survival and increased morbidity. Many patients previously treated with tricuspid valve replacement require further intervention due to bioprosthesis failure. Surgical redo is the “gold standard” treatment however this is technically challenging and associated with significant risk. Percutaneous VIV intervention that is now well established in the management of aortic and mitral bioprosthesis failure may therefore be an alternative treatment option.MethodsThe study population consisted of all patients that underwent percutaneous transcatheter tricuspid VIV implantation for tricuspid bioprosthesis failure at the San Raffaele Scientific Institute, Milan, Italy.ResultsFive patients underwent successful transfemoral transcatheter tricuspid VIV implantation for bioprosthetic failure. One patient suffered acute kidney injury that was successfully medically managed. The remaining patients suffered no complications prior to hospital discharge. During 30‐day follow‐up, all patients reported a significant improvement in their functional status with normal valve function. Additionally, we observed an improvement in renal function (eGFR baseline 62.0 ± 16.5 vs. follow‐up 70.2 ± 23.1 ml/min/m2, P = 0.12) and improved hepatic congestion: bilirubin (1.47 ± 0.8 vs. 1.01 ± 0.7 mg/DL, P = 0.12), alanine aminotransferase (31.0 ± 11.1 vs. 23.2 ± 5.1 U/L, P = 0.11) and aspartate aminotransferase (35.8 ± 6.3 vs. 29.8 ± 13.6 U/L, P = 0.12).ConclusionsTransfemoral, transcatheter VIV treatment with a new generation balloon expandable devices appears to be a safe and efficacious treatment option for tricuspid bioprosthesis failure. © 2016 Wiley Periodicals, Inc.
Tunable Oxygen Functional Groups as Electrocatalysts on Graphite Felt Surfaces for All‐Vanadium Flow Batteries
Authors: Estevez Luis , Reed David , Nie Zimin , Schwarz Ashleigh M , Nandasiri Manjula I. , Kizewski James P , Wang Wei , Thomsen Edwin , Liu Jun , Zhang Ji‐Guang , Sprenkle Vincent , Li Bin 
Published: May 2016

AbstractA dual oxidative approach using O2 plasma followed by treatment with H2O2 to impart oxygen functional groups onto the surface of a graphite felt electrode. When used as electrodes for an all‐vanadium redox flow battery (VRB) system, the energy efficiency of the cell is enhanced by 8.2 % at a current density of 150 mA cm−2 compared with one oxidized by thermal treatment in air. More importantly, by varying the oxidative techniques, the amount and type of oxygen groups was tailored and their effects were elucidated. It was found that O−C=O groups improve the cells performance whereas the C−O and C=O groups degrade it. The reason for the increased performance was found to be a reduction in the cell overpotential after functionalization of the graphite felt electrode. This work reveals a route for functionalizing carbon electrodes to improve the performance of VRB cells. This approach can lower the cost of VRB cells and pave the way for more commercially viable stationary energy storage systems that can be used for intermittent renewable energy storage.
Understanding Complex Electrochemical Impedance Spectroscopy in Corrosion Systems Using in‐situ Synchrotron Radiation Grazing Incidence X‐ray Diffraction
Authors: Alam Muhammad Tanzirul , Wai Lyn Chan Emilyn , De Marco Roland , Huang Yanliang , Bailey Stuart 
Published: May 2016

AbstractThe difficulty in interpreting electrochemical impedance spectroscopy (EIS) data has limited the potential of the method despite its utility as an electrochemical method for studies of electrode reactions and interfacial structures. Taking the test case of the carbon dioxide corrosion of carbon steel, in‐situ synchrotron radiation grazing incidence X‐ray diffraction (SR‐GIXRD) has been demonstrated to be a powerful technique for validating and understanding the interfacial structures associated with complex EIS data. Carbon dioxide corrosion was found to occur in several steps, which may only be surmised by EIS, but the use of SR‐GIXRD in conjunction with EIS has enabled the establishment of a link between EIS time constants and structural changes associated with the evolution of corrosion products with time. By comparison to previous studies by the authors and others in this field, this communication provides the first direct experimental evidence linking SR‐GIXRD surface compositional data to otherwise indistinctive EIS time constants.
Evaluation and comparison of trace metal accumulation in different tissues of potential bioindicator organisms: Macrobenthic filter feeders Styela plicata, Sabella spallanzanii, and Mytilus galloprovincialis
Authors: Bellante Antonio , Piazzese Daniela , Cataldo Salvatore , Parisi Maria Giovanna , Cammarata Matteo 
Published: May 2016

Abstract

Trace metal concentrations were measured in different tissues of Sabella spallanzanii, Styela plicata, and Mytilus galloprovincialis collected in the Termini Imerese Harbor (Sicily, Italy) to evaluate the potential use of these species as bioindicators. Higher bioaccumulation factors (BAFs) were calculated in the tube of S. spallanzanii, except for As, which had a higher BAF in the branchial crown of the same species. Regarding the other species analyzed, higher BAFs were found in the digestive gland of M. galloprovincialis. An exception was Pb, which was significantly more concentrated in the branchial basket and tunic of S. plicata. The BAFs calculated in the present study show that all the species analyzed accumulate a certain amount of metals as a consequence of filter feeding mechanisms, and thus it was possible to assess the suitability of S. plicata, S. spallanzanii, and M. galloprovincialis as indicators of water quality. In particular, the tube of S. spallanzanii is an important compartment in terms of metal retention and is more suitable for the evaluation of contamination from trace elements. Environ Toxicol Chem 2016;35:3062–3070. © 2016 SETAC
Hyperfractionated radiation therapy in Burkitt's lymphoma: a reconsideration aspect
Authors: Charafeddine Khalil , Hilal Lara , Bazarbachi Ali , Salame Nassima , Youssef Bassem 
Published: May 2016

AbstractBurkitt's lymphoma (BL) is an aggressive non‐Hodgkin's B‐cell lymphoma with an extremely short doubling time that often presents in extra nodal sites or as an acute leukaemia. Nowadays, with the rapid response to chemotherapy and the diffuse nature of BL, there is no established role for radiation therapy (RT) even in localized disease. Regarding the relapsed/refractory BL, the treatment recommendations remain undefined.We present a 56‐year‐old woman, diagnosed with BL refractory to 6 cycles of R‐CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone), who had disease progression on R‐DHAP (rituximab, dexamethasone, high dose cytarabine and cisplatin) with intrathecal methotrexate, then a partial response on RICE (rituximab, ifosfamide, carboplatin and etoposide). Patient received high dose chemotherapy and autologous haematopoietic stem cell transplantation. Then, she was treated with hyperfractionated involved‐field RT regimen. Currently, the patient remains disease free for around 2 years after remission.We acknowledge that RT is not a standard treatment of BL, especially in patients who attain complete response (CR) after first‐line multi‐agent chemotherapy or even in those who have a CR after second‐line chemotherapy pre‐transplant. Yet, the use of a superfractionated regimen of consolidative radiation could be justified in the treatment of recurrent/refractory localized BL who do not achieve a CR even with second‐line salvage chemotherapy. Radiation therapy in this context, given that it is a well‐tolerated treatment, is a modality worthy of being re‐considered in relapsed/refractory BL. Copyright © 2016 John Wiley & Sons, Ltd.
Effects of α‐Thalassemia on HbA1c Measurement
Authors: Xu Anping , Ji Ling , Chen Weidong , Xia Yong , Zhou Yu 
Published: May 2016

Backgroundα‐Thalassemia is a benign condition that is often present in patients with diabetes mellitus. Here, we evaluated the effects of different genotypes α‐thalassemia on HbA1c measurement.MethodsA total of 189 samples from nondiabetic patients were analyzed. HbA1c analysis was performed by ion‐exchange high‐performance liquid chromatography, boronate affinity HPLC, immunoassay, and capillary electrophoresis. Fasting glucose, fructosamin, and HbA2 were also performed. All samples were confirmed by genotyping for thalassemia.ResultsIn patients with two or three functional α‐genes, HbA1c values were not significantly different from those of controls (P > 0.05); however, in individuals with α‐thalassemia with one functional α‐gene (i.e., HbH disease), HbA1c levels were significantly different from those of controls (P < 0.01). HbA1c values were significantly lower in individuals with HbH disease than in control individuals and patients in the other two α‐thalassemia groups. For patients with HbH disease, there were no significant differences in the four HbA1c measurement systems (P > 0.05).ConclusionsIn this study, HbA1c values in samples from individuals with two or three functional α‐genes basically reflected the normal mean blood glucose level, while those in samples from individuals with one functional α‐gene did not.
Evaluation of the Role of Circulating Long Non‐Coding RNA H19 as a Promising Novel Biomarker in Plasma of Patients with Gastric Cancer
Authors: Hashad Doaa , Elbanna Amany , Ibrahim Abeer , Khedr Gihan 
Published: May 2016

BackgroundH19 is one of the long non‐coding RNAs (LncRNA) that is related to the progression of many diseases including cancers. This work was carried out to study the level of the long non‐coding RNA; H19, in plasma of patients with gastric cancer (GC) and to assess its significance in their clinical management.MethodsSixty‐two participants were enrolled in the present study. The first group included 32 GC patients. The second group was formed of 30 age and sex matched healthy volunteers serving as a control group. Plasma samples were used to assess H19 gene expression using real‐time quantitative PCR technique.ResultsH19 expression was up‐regulated and closely related to TNM cancer stages in GC patients. Using Receiver Operating Characteristic (ROC) curve analysis, a cutoff level of 0.5 was set for H19 expression to diagnose GC cases achieving a sensitivity of 68.75%, specificity of 56.67%, positive predictive value (PPV) 62.86% and negative predictive value (NPV) 62.96% with an area under the curve (AUC) of 72.4%. Combined use of Carcinoembryonic Antigen (CEA) and H19 level in GC diagnosis was evaluated using ROC curve revealing improvement in performance with an area under the curve of 80.4%.ConclusionsUp‐regulation of H19 is closely associated with gastric cancer displaying progressive up‐regulation in advanced stages of the disease implementing its role as a potential non‐invasive diagnostic biomarker in gastric cancer and as a novel tool in gastric cancer management with better performance achieved on using both CEA and H19 simultaneously.
A Comparison of Mindray BC‐6800, Sysmex XN‐2000, and Beckman Coulter LH750 Automated Hematology Analyzers: A Pediatric Study
Authors: Ciepiela Olga , Kotuła Iwona , Kierat Szymon , Sieczkowska Sandra , Podsiadłowska Anna , Jenczelewska Anna , Księżarczyk Karolina , Demkow Urszula 
Published: May 2016

BackgroundModern automated laboratory hematology analyzers allow the measurement of over 30 different hematological parameters useful in the diagnostic and clinical interpretation of patient symptoms. They use different methods to measure the same parameters. Thus, a comparison of complete blood count made by Mindray BC‐6800, Sysmex XN‐2000 and Beckman Coulter LH750 was performed.Materials and methodsA comparison of results obtained by automated analysis of 807 anticoagulated blood samples from children and 125 manual microscopic differentiations were performed. This comparative study included white blood cell count, red blood cell count, and erythrocyte indices, as well as platelet count.ResultsThe present study showed a poor level of agreement between white blood cell enumeration and differentiation of the three automated hematology analyzers under comparison. A very good agreement was found when comparing manual blood smear and automated granulocytes, monocytes, and lymphocytes differentiation. Red blood cell evaluation showed better agreement than white blood cells between the studied analyzers.ConclusionTo conclude, studied instruments did not ensure satisfactory interchangeability and did not facilitate a substitution of one analyzer by another.