bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyamide/polyacrylonitrile thin film composites as forward osmosis membranes
Authors: Hajighahremanzadeh Parisa , Abbaszadeh Mahsa , Mousavi Seyyed Abbas , Soltanieh Mohammad , Bakhshi Hadi 
Published: July 2016

ABSTRACTThin film composites (TFCs) as forward osmosis (FO) membranes for seawater desalination application were prepared. For this purpose, polyacrylonitrile (PAN) as a moderately hydrophilic polymer was used to fabricate support membranes via nonsolvent‐induced phase inversion. A selective thin polyamide (PA) film was then formed on the top of PAN membranes via interfacial polymerization reaction of m‐phenylenediamine and trimesoyl chloride (TMC). The effects of PAN solution concentration, solvent mixture, and coagulation bath temperature on the morphology, water permeability, and FO performance of the membranes and composites were studied. Support membranes based on low PAN concentrations (7 wt %), NMP as solvent and low coagulation bath temperature (0 °C) demonstrated lower thickness, thinner skin layer, more porosity, and higher water permeability. Meanwhile, decreasing the PAN solution concentration lead to higher water permeance and flux and lower reverse salt flux, structural parameter, and tortuosity for the final TFCs. Composites made in N,N‐dimethylformamide presented lower permeance and flux for water and salt and higher salt rejection, structural parameter, and tortuosity. FO assay of the composites showed lower water permeance values in saline medium comparing to pure water. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44130.
Controlled co‐delivery of hydrophilic and hydrophobic drugs from thermosensitive and crystallizable copolymer nanoparticles
Authors: Xu Xianbo , Shan Guorong R. , Pan Pengju 
Published: July 2016

ABSTRACTFunctionalized amphiphilic block copolymers poly(N‐isopropyl acrylamide)‐b‐poly(stearyl methacrylate) (PNIPAM‐PSMA) are synthesized. Their self‐assembled core‐shell nanoparticles have the hydrophilic thermosensitive shell and hydrophobic crystallizable core. Nanoparticles exhibit volume phase transition at temperature of 38  °C and its poly(stearyl methacrylate) (PSMA) moiety could form nano size crystals to retain drugs, making them good carriers for drug co‐delivery system. Thermosensitivity and crystallinity of nanoparticles are characterized with dynamic light scattering (DLS), differential scanning calorimetry (DSC), small‐angle X‐ray scattering (SAXS), and atomic force microscopy (AFM). The interactions and relationship between chemical structures of copolymer nanoparticles and loading drugs are discussed. Different loading techniques and combined loading of hydrophobic/hydrophilic drugs are studied. Nanoparticles show a good and controllable drug loading capacity (DL) of hydrophilic/hydrophobic drugs. The drugs release kinetics is analyzed with Fick's law and Weibull model. A general method for analyzing drug release kinetics from nanoparticles is proposed. Weibull model is well fitted and the parameters with definite physical meaning are analyzed. PNIPAM‐PSMA nanoparticles show a quite different thermal response, temporal regulation, and sustained release effect of hydrophilic and hydrophobic drugs, suggesting a promising application in extended and controlled co‐delivery system of multi‐drug. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44132.
Synthesis and application of sodium 2‐acrylamido‐2‐methylpropane sulphonate/N‐vinylcaprolactam/divinyl benzene as a high‐performance viscosifier in water‐based drilling fluid
Authors: Xie Binqiang , Liu Xiaodong , Wang Huiqiang , Zheng Lihui 
Published: July 2016

ABSTRACTAiming at good thickening ability and temperature resistance in water‐based drilling fluid, a novel copolymer viscosifier (SDKP) of sodium 2‐acrylamido‐2‐methylpropane sulfonate (NaAMPS) with N‐vinylcaprolactam (NVCL) and cross‐linking divinylbenzene (DVB) was prepared by micellar radical polymerization. The composition and molecular structure of optimal SDKP under the optimum reaction conditions was characterized by FT‐IR, 1H‐NMR, and elemental analysis, and the molecular weight was determined by GPC. Thermal gravimetric analysis showed that the SDKP was even stable when the temperature was not higher than 330 °C. The performance of SDKP as viscosifier for aqueous, brines, and saturated brine bentonite drilling fluid was evaluated before and after aging tests at 230 °C for 16 h. The evaluation results indicated that the SDKP had excellent thickening ability, thermal resistant, and salt tolerance. HTHP rheology test showed that the SDKP containing drilling fluids displayed a thermo‐thickening effect in temperature range of 150 to 180 °C, which was beneficial to increase the viscosity and strength of fluids at high temperatures. Shear test showed that the SDKP illustrated a similar shear thinning to xanthan gum. ESEM observations demonstrated that the continuous three‐dimensional network was formed in the SDKP aqueous and brines solution, which was probably the main reason for its excellent thickening properties. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44140.
Biogasdoneright™: An innovative new system is commercialized in Italy
Authors: Dale Bruce E. , Sibilla Fabrizio , Fabbri Claudio , Pezzaglia Marco , Pecorino Biagio , Veggia Ezio , Baronchelli Angelo , Gattoni Piero , Bozzetto Stefano 
Published: July 2016

AbstractA group of over 600 Italian farmers organized as the Italian Biogas Consortium are redesigning their own farming systems to produce food and bioenergy in a nationwide farm‐level movement called Biogasdoneright™. This Feature demonstrates how it is possible to simultaneously increase the economic viability and stability of agriculture by reducing farm input costs and enabling farmers to produce food and fuel more sustainably. © 2016 Society of Chemical Industry and John Wiley & Sons, Ltd
TKI combination therapy: strategy to enhance dasatinib uptake by inhibiting Pgp‐ and BCRP‐mediated efflux
Authors: D'Cunha Ronilda , Bae SoHyun , Murry Daryl J. , An Guohua 
Published: July 2016

AbstractThe overexpression of efflux transporters, especially P‐glycoprotein (Pgp, MDR1, ABCB1) and breast cancer resistance protein (BCRP, ABCG2), represents an important mechanism of multidrug resistance (MDR). Tyrosine kinase inhibitors (TKIs), a novel group of target‐specific anticancer drugs, have recently been found to interact with Pgp and BCRP and to serve as both substrates and inhibitors. Considering their dual role, we anticipate that combination TKI therapy may represent a promising strategy to reverse efflux transporter mediated TKI resistance. Presently, investigations on these interactions are very limited. To fill the literature gap, dasatinib was used as the model drug and the effects of various TKIs on Pgp‐ and BCRP‐ mediated dasatinib efflux were evaluated. Cell uptake studies were performed using LLC‐PK1 and MDCK‐II cells along with their subclones that were transfected with human Pgp and BCRP, respectively. Among the 14 TKIs screened, nine TKIs greatly inhibited Pgp‐mediated dasatinib efflux at 50 μm. Further concentration dependent studies showed that imatinib, nilotinib and pazopanib were potent Pgp inhibitors with IC50 values of 2.42, 6.11 and 8.06 μm, respectively. Additionally, 50 μm of five TKIs greatly increased dasatinib accumulation through BCRP inhibition. Concentration dependent studies revealed that imatinib, erlotinib, nilotinib, axitinib and pazopanib were potent BCRP inhibitors with IC50 values of 0.94, 2.23, 2.50, 6.89 and 10.4 μm, respectively. Our findings point to potential combinations of TKIs that could enhance intracellular concentrations of the targeted TKI, overcome MDR and improve TKI efficacy. Further in vivo studies are warranted to confirm the efflux transporter‐mediated TKI–TKI interaction. Copyright © 2016 John Wiley & Sons, Ltd.
Factor VIII associated with lipidic nanoparticles retains efficacy in the presence of anti‐factor VIII antibodies in hemophilia A mice
Authors: Shetty Krithika A. , Kosloski Matthew P. , Mager Donald E. , Balu‐Iyer Sathy V. 
Published: July 2016

AbstractThe development of inhibitory antibodies against factor VIII (FVIII) is a major challenge in hemophilia A (HA) therapy. Such antibodies develop in nearly 30% of patients receiving replacement FVIII, abrogating therapeutic efficacy. This work evaluated whether B‐domain deleted FVIII encapsulated in phosphatidylinositol containing lipid nanoparticles (PI‐BDD FVIII) could serve as an efficacious FVIII replacement therapy in the presence of inhibitors. The HA mice were given clinically relevant doses of FVIII to develop inhibitors. The efficacy of free and PI‐BDD FVIII was studied in inhibitor‐positive HA mice using a tail clip assay. Mathematical modeling of these data was conducted to evaluate the hypothesis that lipid association sterically shields the protein from inhibitor binding. The immunization protocol resulted in a mean inhibitory titer level of 198 ± 52 BU/ml. Free BDD FVIII was ineffective at controlling blood loss in inhibitor‐positive HA mice as early as 2 h post dose. In contrast, PI‐BDD FVIII treated animals retained partial hemostatic efficacy as long as 18 h post dose. Mathematical modeling supports the hypotheses that a greater fraction of lipid‐associated FVIII remains unbound to inhibitors and that PI‐BDD FVIII has lower binding affinity to inhibitors than does the free protein. In addition, the modeling approaches extend current efforts to model the impact of immunogenicity on PK and the therapeutically meaningful endpoint of efficacy, thereby addressing an important knowledge gap, particularly in the FVIII scientific literature. Clinical translation of these findings could result in a significant improvement in the quality of care of inhibitor‐positive HA patients. Copyright © 2016 John Wiley & Sons, Ltd.
Assembly of Multi‐Phthalocyanines on a Porphyrin Template by Fourfold Rotaxane Formation
Authors: Yamada Yasuyuki , Kato Tatsuhisa , Tanaka Kentaro 
Published: July 2016

AbstractA stacked assembly composed of a porphyrin and two phthalocyanines was prepared through fourfold rotaxane formation. Two phthalocyanine molecules, bearing four 24‐crown‐8 units, were assembled onto a porphyrin template incorporating four sidechains with two dialkylammonium ions each through pseudorotaxane formation between crown ether units and ammonium ions. The Staudinger phosphite reaction, as the stoppering reaction, resulted in the formation of the stacked heterotrimer composed of a porphyrin and two phthalocyanines connected through a fourfold rotaxane structure. UV/Vis spectroscopic and electrochemical studies of the heterotrimer indicated that there is a significant electronic interaction between the two phthalocyanine units due to the close stacking. The electrochemical oxidation process of the stacked heterotrimer was studied by cyclic voltammetry and spectroelectrochemistry. Electron paramagnetic resonance (EPR) spectroscopy of a dinuclear CuII complex, in which two CuII phthalocyanines were assembled on a metal‐free porphyrin template, revealed that two CuII phthalocyanines were located within the stacking distance, which resulted in an antiferromagnetic interaction between the two S=
spins in the ground state of the Cu2+ ions in the heterotrimer.
Pseudopeptide‐Based Hydrogels Trapping Methylene Blue and Eosin Y
Authors: Milli Lorenzo , Zanna Nicola , Merlettini Andrea , Di Giosia Matteo , Calvaresi Matteo , Focarete Maria Letizia , Tomasini Claudia 
Published: July 2016

AbstractWe present herein the preparation of four different hydrogels based on the pseudopeptide gelator Fmoc‐l‐Phe‐d‐Oxd‐OH (Fmoc=fluorenylmethyloxycarbonyl), either by changing the gelator concentration or adding graphene oxide (GO) to the water solution. The hydrogels have been analysed by rheological studies that demonstrated that pure hydrogels are slightly stronger compared to GO‐loaded hydrogels. Then the hydrogels efficiency to trap the cationic methylene blue (MB) and anionic eosin Y (EY) dyes has been analyzed. MB is efficiently trapped by both the pure hydrogel and the GO‐loaded hydrogel through π–π interactions and electrostatic interactions. In contrast, the removal of the anionic EY is achieved in less satisfactory yields, due to the unfavourable electrostatic interactions between the dye, the gelator and GO.
De la congruence de valeurs à la marque employeur: quelles conséquences pour l'identification et le bouche‐à‐oreille vis‐à‐vis de l'organisation?
Authors: Charbonnier‐Voirin Audrey , Poujol Juliet F. , Vignolles Alexandra 
Published: July 2016

AbstractThe war for talent has led organizations to develop a strong employer brand to attract and retain skilled employees. Few studies have examined the antecedents and consequences of the internal employer brand. We focus on the influence of employee‐organization values congruence on the employee's perception of the employer brand and on the influence of the employer brand on organizational identification and positive word‐of‐mouth vis‐à‐vis the employer. Results from a survey of 308 employees show that the employer brand fully mediates the relationship between values congruence and organizational identification and positive word‐of‐mouth. These results have theoretical and managerial implications in terms of employer branding. Copyright © 2016 ASAC. Published by John Wiley & Sons, Ltd.
Fragment‐Based Discovery of 5‐Arylisatin‐Based Inhibitors of Matrix Metalloproteinases 2 and 13
Authors: Agamennone Mariangela , Belov Dmitry S. , Laghezza Antonio , Ivanov Vladimir N. , Novoselov Anton M. , Andreev Ivan A. , Ratmanova Nina K. , Altieri Andrea , Tortorella Paolo , Kurkin Alexander V. 
Published: July 2016

AbstractMatrix metalloproteinases (MMPs) are well‐established targets for several pathologies. In particular, MMP‐2 and MMP‐13 play a prominent role in cancer progression. In this study, a structure‐based screening campaign was applied to prioritize metalloproteinase‐oriented fragments. This computational model was applied to a representative fragment set from the publically available EDASA Scientific compound library. These fragments were prioritized, and the top‐ranking hits were tested in a biological assay to validate the model. Two scaffolds showed consistent activity in the assay, and the isatin‐based compounds were the most interesting. These latter fragments have significant potential as tools for the design and realization of novel MMP inhibitors. In addition to their micromolar activity, the chemical synthesis affords flexible and creative access to their analogues.
Phase 1 and 2 study of carboplatin and pralatrexate in patients with recurrent, platinum‐sensitive ovarian, fallopian tube, or primary peritoneal cancer
Authors: del Carmen Marcela G. , Supko Jeff G. , Horick Nora K. , Rauh‐Hain J. Alejandro , Clark Rachel M. , Campos Susana M. , Krasner Carolyn N. , Atkinson Tina , Birrer Michael J. 
Published: July 2016

BACKGROUNDThe objective of this phase 1 and 2 trial was to identify the appropriate dose of combined carboplatin and pralatrexate for patients with recurrent, platinum‐sensitive ovarian, fallopian tube, and primary peritoneal cancer.METHODSIn phase 1, patients received carboplatin (at an area under the curve of 5) and increasing doses of pralatrexate until the maximum‐tolerated dose (MTD) of pralatrexate was achieved. The primary endpoint was the response rate. Additional endpoints were safety, response duration, progression‐free survival, overall survival, and pharmacokinetics.RESULTSThirty patients were enrolled in phase 1, and 20 were enrolled in phase 2. Of all 50 patients, 49 completed the study. The mean patient age was 59 years, and patients completed a median of 6 cycles. The MTD for pralatrexate was 105 mg/m2. The clinical benefit rate (complete responses plus partial responses plus stable disease) was 86%. Of 26 patients who received the MTD, 12 had a partial response, 11 had stable disease, and 2 had disease progression. The progression‐free survival rate at 3 and 6 months was 87% and 79%, respectively; and the overall survival rate was 98% at 6 and 12 months and 66% at 24 months. Of 30 patients, 18 (60%) in phase 1 experienced an adverse event of any grade; and, of those, 4 patients (13%) had a grade 3 or greater adverse event. In phase 2, 12 patients (60%) had an adverse event of any grade, and 4 (20%) had grade 3 or greater toxicity. There was a significant reduction in the total body clearance of pralatrexate when it was received concurrently with carboplatin.CONCLUSIONSMost patients responded to carboplatin‐pralatrexate combination. This regimen is well tolerated and effective in this patient population. Cancer 2016;122:3297–3306. © 2016 American Cancer Society.
A comparative analysis of survival outcomes between pancreatectomy and chemotherapy for elderly patients with adenocarcinoma of the pancreas
Authors: Marmor Schelomo , Burke Erin E. , Virnig Beth A. , Jensen Eric H. , Tuttle Todd M. 
Published: July 2016

BACKGROUNDThe survival rates after pancreatectomy for elderly patients with adenocarcinoma of the pancreas remain poor. Elderly patients have increased perioperative mortality rates, higher morbidity rates, and higher rates of continued inpatient nursing care after pancreatectomy. The objective of the current study was to evaluate the outcomes of surgical resection versus chemotherapy (with or without radiotherapy) for elderly patients with potentially resectable adenocarcinoma of the pancreas.METHODSUsing Surveillance, Epidemiology, and End Results (SEER)‐Medicare data for 2000 through 2010, the authors examined the relationship between patient characteristics and receipt of surgery using multivariate logistic regression. The patient cohort was restricted to patients with American Joint Committee on Cancer stage I and stage II disease and Charlson Comorbidity index of ≤2. The association between treatment (surgery or chemotherapy without surgery) and hazard of death was evaluated using Kaplan‐Meier Cox proportional hazards modeling.RESULTSThe authors identified 2629 patients with pancreatic adenocarcinoma who underwent either surgery (pancreatectomy) or chemotherapy without surgery. Younger patient age and smaller tumor size were found to be significantly associated with receipt of surgery. For the overall cohort, the median survival rate was significantly longer for those patients treated with surgery compared with those who received chemotherapy (15 months vs 10 months). However, the absolute survival benefit attenuated as the cohort became older.CONCLUSIONSThe survival benefit associated with surgical resection compared with chemotherapy was very small for certain subgroups of patients (those aged ≥80 years and those with lymph node metastases). The results of the current study indicate that although surgery is associated with a survival benefit in the elderly, chemotherapy should be considered as a legitimate therapeutic alternative. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:3378–3385. © 2016 American Cancer Society.
A community‐based trial of educational interventions with fecal immunochemical tests for colorectal cancer screening uptake among blacks in community settings
Authors: Christy Shannon M. , Davis Stacy N. , Williams Kimberly R. , Zhao Xiuhua , Govindaraju Swapomthi K. , Quinn Gwendolyn P. , Vadaparampil Susan T. , Lin Hui‐Yi , Sutton Steven K. , Roethzeim Richard R. , Shibata David , Meade Cathy D. , Gwede Clement K. 
Published: July 2016

BACKGROUNDIntervention studies among individuals in diverse community settings are needed to reduce health disparities in colorectal cancer (CRC) screening and mortality rates. The current study compared the efficacy of 2 intervention conditions promoting CRC screening among black individuals.METHODSBlack individuals ages 50 to 75 years (N = 330) were recruited in community settings in 4 Tampa Bay counties. After obtaining consent and conducting a baseline interview to assess sociodemographic and health‐related variables, participants received either a culturally targeted CRC photonovella booklet plus a fecal immunochemical test (FIT) kit or a standard CRC screening brochure plus an FIT kit. The primary outcome was FIT kit screening uptake.RESULTSFIT screening uptake at 6 months was 86.7% overall (90.3% in the brochure group and 81.9% in the photonovella group). Controlling for baseline between‐group differences, there was no influence of intervention on FIT kit uptake (P = .756). Significant predictors of not returning an FIT kit included being unable to work (P = .010), having higher religious belief scores (P = .015), and living farther from the cancer center (P = .015).CONCLUSIONSProviding FIT kits and educational print materials to black individuals in community settings resulted in high rates of CRC screening. The study also identified subgroups of participants who were less likely to return an FIT kit and provides insight for future interventions. Cancer 2016;122:3288–3296. © 2016 American Cancer Society.
Artificial Molecular Photosynthetic Systems: Towards Efficient Photoelectrochemical Water Oxidation
Authors: Yamamoto Masanori , Tanaka Koji 
Published: July 2016

AbstractArtificial photosynthesis is of great importance in the production of clean fuels such as hydrogen from sunlight and water. In such systems, water oxidation is kinetically demanding; therefore, efficient catalysts and systems for water oxidation are required. Among the artificial systems, photosynthesis has been recently developed owing to the emergence of efficient molecular catalysts for water oxidation. This Review highlights several important concepts including electron transfer and catalysis, and the representative systems of molecular systems for visible‐light‐driven water oxidation. In addition, the remaining challenges in this field, including the interfacial recombination and the restricted utilization of visible light of over 500 nm, are discussed.
Factors that affect parasitism of black‐tailed prairie dogs by fleas
Authors: Eads David A. , Hoogland John L. 
Published: July 2016

AbstractFleas (Insecta: Siphonaptera) are hematophagous ectoparasites that feed on vertebrate hosts. Fleas can reduce the fitness of hosts by interfering with immune responses, disrupting adaptive behaviors, and transmitting pathogens. The negative effects of fleas on hosts are usually most pronounced when fleas attain high densities. In lab studies, fleas desiccate and die under dry conditions, suggesting that populations of fleas will tend to decline when precipitation is scarce under natural conditions. To test this hypothesis, we compared precipitation vs. parasitism of black‐tailed prairie dogs (Cynomys ludovicianus) by fleas at a single colony during May and June of 13 consecutive years (1976–1988) at Wind Cave National Park, South Dakota, USA. The number of fleas on prairie dogs decreased with increasing precipitation during both the prior growing season (April through August of the prior year) and the just‐completed winter–spring (January through April of current year). Due to the reduction in available moisture and palatable forage in dry years, herbivorous prairie dogs might have been food‐limited, with weakened behavioral and immunological defenses against fleas. In support of this hypothesis, adult prairie dogs of low mass harbored more fleas than heavier adults. Our results have implications for the spread of plague, an introduced bacterial disease, transmitted by fleas, that devastates prairie dog colonies and, in doing so, can transform grassland ecosystems.