bluuebunny/crossref_metadata_2025_split huggingface dataset:
Residência multiprofissional em saúde: tem valido a pena?
Authors: Fiorano Ana Maria Marcondes , Guarnieri Ana Paula 
Published: December 2015

Introdução: Foram criados programas de Residência Multiprofissional em Saúde na Faculdade de Medicina do ABC (FMABC), na Atenção ao Câncer e na ao Idoso, com a primeira turma iniciada em 2014. Contando com 22 residentes e outros 22 que ingressaram em 2015, os programas consideram os princípios do Sistema Único de Saúde (SUS) e mantêm seus projetos pedagógicos alinhados às premissas da instituição. Relato de experiência: Em parceria com os municípios de Santo André, São Bernardo do Campo e São Caetano do Sul, é garantida a viabilização desses programas, os quais abrangem estratégias metodológicas que levam os residentes para a prática,possibilitando atividades interdisciplinares nas áreas de Enfermagem, Farmácia, Fisioterapia, Nutrição e Terapia Ocupacional. A articulação entre a FMABC e políticas de saúde dos munícipios propicia a execução dos programas nos três níveis de assistência e, devido talpactuação, os residentes foram distribuídos e fixados nos municípios para melhor compreenderem a dinâmica dos serviços. No entanto, essa situação apresentou dificuldades devido às estruturas incompletas em alguns municípios. O esforço nessa integração se mantém de modo contínuo, buscando envolver a comunidade e adequando as práticas aos problemas predominantes. Para incentivar os preceptores nesse processo, a FMABC oferece bolsas de pós‑graduação. Conclusão: A falta de recursos provenientes dos Ministérios para alavancar os programas por meio de incentivos financeiros aos colaboradores de todas as instâncias e dificuldades de articulação entre os municípios dadas as diferentes estratégias de políticas de saúde têm se mostrado limitantes na execução dos projetos apresentados.
The revised Temperament and Character Inventory: normative data by sex and age from a Spanish normal randomized sample
Authors: Gutierrez-Zotes Alfonso , Labad Javier , Martorell Lourdes , Gaviria Ana , Bayón Carmen , Vilella Elisabet , Cloninger C. Robert 
Published: December 2015

Objectives.The psychometric properties regarding sex and age for the revised version of the Temperament and Character Inventory (TCI-R) and its derived short version, the Temperament and Character Inventory (TCI-140), were evaluated with a randomized sample from the community.Methods.A randomized sample of 367 normal adult subjects from a Spanish municipality, who were representative of the general population based on sex and age, participated in the current study. Descriptive statistics and internal consistency according toαcoefficient were obtained for all of the dimensions and facets.T-tests and univariate analyses of variance, followed by Bonferroni tests, were conducted to compare the distributions of the TCI-R dimension scores by age and sex.Results.On both the TCI-R and TCI-140, women had higher scores for Harm Avoidance, Reward Dependence and Cooperativeness than men, whereas men had higher scores for Persistence. Age correlated negatively with Novelty Seeking, Reward Dependence and Cooperativeness and positively with Harm Avoidance and Self-transcendence. Young subjects between 18 and 35 years had higher scores than older subjects in NS and RD. Subjects between 51 and 77 years scored higher in both HA and ST. The alphas for the dimensions were between 0.74 and 0.87 for the TCI-R and between 0.63 and 0.83 for the TCI-140.Conclusion.Results, which were obtained with a randomized sample, suggest that there are specific distributions of personality traits by sex and age. Overall, both the TCI-R and the abbreviated TCI-140 were reliable in the ‘good-to-excellent’ range. A strength of the current study is the representativeness of the sample.
Emergency Department Process Times and Door-In–Door-Out Times in Interhospital Transfers After Acute Ischemic Stroke
Authors: Royan Regina , Stamm Brian , Giurcanu Mihai , Messe Steven R. , Jauch Edward C. , Prabhakaran Shyam 
Published: September 2024

ImportanceStroke treatment is exquisitely time sensitive. The door-in–door-out (DIDO) time, defined as the total time spent in the emergency department (ED) at a transferring hospital, is an important quality metric for the care of acute stroke. However, little is known about the contributions of specific process steps to delays and disparities in DIDO time.ObjectiveTo quantify process steps and their association with DIDO times at transferring hospitals among patients with acute ischemic stroke (AIS).Design, Setting, and ParticipantsThis retrospective cohort study analyzed patients in the American Heart Association Get With the Guidelines–Stroke registry with AIS presenting between January 1, 2019, to December 31, 2021, and transferred from the presenting hospital ED to another acute care hospital for evaluation of thrombolytics, endovascular therapy, or postthrombolytic care. Data were analyzed from July 8 to October 13, 2023.ExposuresIntervals of ED care of ischemic stroke: door-to-imaging and imaging-to-door times.Main Outcomes and MeasuresThe primary outcome was DIDO time. Multivariate generalized estimating equations regression models were performed to compare contributions of interval process times to explain variation in DIDO time, controlling for patient- and hospital-level characteristics.ResultsAmong 28 887 patients (50.5% male; mean [SD] age, 68.3 [14.8] years; 5.5% Hispanic, 14.7% non-Hispanic Black, and 73.2% non-Hispanic White), mean (SD) DIDO time was 171.4 (149.5) minutes, mean (SD) door-to-imaging time was 18.3 (34.1) minutes, and mean (SD) imaging-to-door time was 153.1 (141.5) minutes. In the model adjusting for door-to-imaging time, the following were associated with longer DIDO time: age 80 years or older (compared with 18-59 years; 5.97 [95% CI, 1.02-10.92] minutes), female sex (5.21 [95% CI, 1.55-8.87] minutes), and non-Hispanic Black race (compared with non-Hispanic White 10.09 [95% CI, 4.21-15.96] minutes). In the model including imaging-to-door time as a covariate, disparities in DIDO by age and female sex became nonsignificant, and the disparity by Black race was attenuated (2.32 [95% CI, 1.09-3.56] minutes).Conclusions and RelevanceIn this national cohort study of interhospital transfer of patients with AIS, delays in DIDO time by Black race, older age (≥80 years), and female sex were largely explained by the imaging-to-door period, suggesting that future systems interventions should target this interval to reduce these disparities. While existing guidelines and care resources heavily focus on reducing door-to-imaging times, further attention is warranted to reduce imaging-to-door times in the management of patients with AIS who require interhospital transfer.
Extrinsic Self‐Trapped‐Exciton Emission in Cs5Cu3Cl6I2 for Efficient X‐Ray Scintillation
Authors: Nan Yang , Wang Chengcheng , Zhang Guangbin , Kuang Zhiyuan , Liu Wenbo , Zhou Mingmin , Zhang Xiuying , Dai Shuheng , Ran Peng , Xu Xinqi , Chen Qiushui , Yang Yang (Michael) , Zhu Lin , Peng Qiming , Wang Nana , Wang Jianpu 
Published: September 2024

AbstractEfficient and stable scintillators play a crucial role in X‐ray detection applications. To enhance the luminescence efficiency under X‐ray excitation, the incorporation of multiple emission centers into scintillators is widely explored. Here, it is found that the cesium copper halide Cs5Cu3Cl6I2 exhibits dual emission centers, enabling high‐performance scintillators with an X‐ray light yield of 49000 photon MeV−1 and a low detection limit of 4 nGy s−1. The emissions of Cs5Cu3Cl6I2 are from intrinsic self‐trapped exciton (STE) and Frenkel defect‐assisted STE. High‐energy X‐rays can induce an increased fraction of Frenkel defect‐assisted STEs, which can serve as an effective scintillation channel. Furthermore, large‐area flexible scintillators with a high resolution of 18 lp mm−1 are developed, making them suitable for X‐ray imaging applications. These findings offer promising insights for developing more efficient scintillators.
Platelet‐Derived Growth Factor C Facilitates Malignant Behavior of Pancreatic Ductal Adenocarcinoma by Regulating SREBP1 Mediated Lipid Metabolism
Authors: Shi Yin‐Hao , Liu Zhi‐De , Ma Ming‐Jian , Zhao Guang‐Yin , Zhu Ying‐Qin , Wang Jie‐Qin , Yu Yang‐Yin‐Hui , Huang Xi‐Tai , Ye Jing‐Yuan , Li Fu‐Xi , Wang Xi‐Yu , Xu Qiong‐Cong , Yin Xiao‐Yu 
Published: September 2024

AbstractLipid metabolism reprogramming stands as a fundamental hallmark of cancer cells. Unraveling the core regulators of lipid biosynthesis holds the potential to find promising therapeutic targets in pancreatic ductal adenocarcinoma (PDAC). Here, it is demonstrated that platelet‐derived growth factor C (PDGFC) orchestrated lipid metabolism, thereby facilitated the malignant progression of PDAC. Expression of PDGFC is upregulated in PDAC cohorts and is corelated with a poor prognosis. Aberrantly high expression of PDGFC promoted proliferation and metastasis of PDAC both in vitro and in vivo. Mechanistically, PDGFC accelerated the malignant progression of PDAC by upregulating fatty acid accumulation through sterol regulatory element‐binding protein 1 (SREBP1), a key transcription factor in lipid metabolism. Remarkably, Betulin, an inhibitor of SREBP1, demonstrated the capability to inhibit proliferation and metastasis of PDAC cell lines, along with attenuating the process of liver metastasis in vivo. Overall, the study underscores the pivotal role of PDGFC‐mediated lipid metabolism in PDAC progression, suggesting PDGFC as a potential biomarker for PDAC metastasis. Targeting PDGFC‐induced lipid metabolism emerges as a promising therapeutic strategy for metastatic PDAC, with the potential to improve clinical outcomes.
Ultrafast Decay of Interlayer Exciton in WS2/MoSe2 Heterostructure Under Pressure
Authors: Bai Zhiying , Zhang He , He Jiaqi , He Dawei , Wang Jiarong , Wu Wenwen , Zhang Yinglin , Wang Wenjie , Wang Yongsheng , Yu Xiaohui , Zhang Xiaoxian 
Published: September 2024

AbstractAtomically thin transition metal dichalcogenides (TMDs) heterostructures provide a rich platform for exploring fascinating physics and engineering strategies. A pressure strategy is developed to effectively manipulate the physical properties in such heterostructures. However, there is still a lack of studies on the corresponding pressure‐modulated evolution of carrier dynamics, which is crucial to the performance of electronic and optoelectronic devices. Here, utilizing the diamond anvil cell, the interlayer exciton dynamics of WS2/MoSe2 heterostructure are subtly manipulated by pressure. Intriguingly, with pressure modulation, the enhanced interlayer coupling accelerates the recombination of spatially separated electron and hole, which significantly shortens the interlayer exciton lifetime from 37.10 ps at 0.0 Gpa to 3.03 ps at 2.2 Gpa. For comparison, the intralayer exciton lifetime of monolayer MoSe2 is increased due to the transition of direct to indirect bandgap under pressure. Furthermore, the pressure‐regulated band structure and interlayer coupling are confirmed by photoluminescence and Raman spectroscopy. The results demonstrate that pressure provides a powerful tuning knob for interlayer exciton relaxation of TMDs heterostructure, which is attractive to various electronic and optoelectronic applications based on such heterostructure.
Direct application of tungstosilicic acid hydrate for the treatment of high free fatty acid in acidic crude palm oil and for biodiesel production
Authors: Hayyan Adeeb , Abed Khalid M. , Hayyan Maan , Ali Ahmed Jawad , Basirun Wan Jefrey , Putra Sharifah Shahira Syed , Alias Yatimah , Alanazi Yousef Mohammed , Saleh Jehad , Hashim Mohd Ali , Gupta Bhaskar Sen 
Published: September 2024

AbstractThis study explored the use of industrial acidic crude palm oil (ACPO) for biodiesel production, facing a significant obstacle due to its high free fatty acid (FFA) content, which complicates the biodiesel production process. Typically, esterification is employed to convert FFAs into fatty acid methyl ester (FAME). Herein, the effectiveness of tungstosilicic acid hydrate (TSAH) as an unsupported heteropoly acid (HPA) catalyst for FFA esterification in ACPO was investigated. The FFA content was reduced from 8.43% to 0.95% under optimum conditions (4 wt% catalyst dosage, a methanol to oil molar ratio of 10:1, 150 min and a temperature of 60°C). Noteworthy, the TSAH catalyst showed stability over 7 cycles. The kinetic analysis revealed that the FFA esterification process closely followed pseudo first‐order kinetics, with an R2 value of 0.94. Furthermore, the biodiesel produced from TSAH‐treated ACPO meets the standard specifications outlined by ASTM D6751 and EN 14214. This research highlights the effectiveness of TSAH in catalyzing FFA esterification without the need for additional support materials or modifications.
Transitive inference in a clinical childhood sample with a focus on autism spectrum disorder
Authors: Kao Tina , Michaelcheck Charlotte , Ferrera Vincent P. , Terrace Herbert S. , Jensen Greg 
Published: September 2024

AbstractTransitive inference (TI) has a long history in the study of human development. There have, however, few pediatric studies that report clinical diagnoses have tested trial‐and‐error TI learning, in which participants infer item relations, rather than evaluate them explicitly from verbal descriptions. Children aged 8–10 underwent a battery of clinical assessments and received a range of diagnoses, potentially including autism spectrum disorder (ASD), attention‐deficit hyperactive disorder (ADHD), anxiety disorders (AD), specific learning disorders (SLD), and/or communication disorders (CD). Participants also performed a trial‐and‐error learning task that tested for TI. Response accuracy and reaction time were assessed using a statistical model that controlled for diagnostic comorbidity at the group level. Participants in all diagnostic categories showed evidence of TI. However, a model comparison analysis suggested that those diagnosed with ASD succeeded in a qualitatively different way, responding more slowly to each choice and improving faster across trials than their non‐ASD counterparts. Additionally, TI performance was not associated with IQ. Overall, our data suggest that superficially similar performance levels between ASD and non‐ASD participants may have resulted from a difference in the speed‐accuracy tradeoff made by each group. Our work provides a preliminary profile of the impact of various clinical diagnoses on TI performance in young children. Of these, an ASD diagnosis resulted in the largest difference in task strategy.
Synergetic Combination of Carbon Xerogels, Graphene Oxide and nano‐ZnO for Aqueous and Organic Supercapacitors
Authors: Coneo‐Rodríguez Rusbel , Tesio Alvaro Yamil , Cometto Fernando Pablo , Morales Gustavo Marcelo , Planes Gabriel Ángel , Caballero Alvaro 
Published: September 2024

AbstractThree‐dimensional carbon xerogels were synthesised via a facile approach that included the use of ZnO nanostructures both as a templating agent and as a catalyst for resorcinol–formaldehyde resin (R−F) polymerisation simultaneously. Graphene oxide (GO) served as a stabilising agent during the drying and pyrolysis processes, avoiding the collapse of structure and improving the area surface. The method enabled the as‐obtained materials to possess optimised 3D porous structures for energy‐storage devices, such as wires or spaghetti‐like structures. Also, a high BET surface area was obtained (1661 m2 g−1) without using an additional activating agent. This great surface area improved the specific capacitance compared to materials without GO (358.1 F g−1 vs 170.4 F g−1). The carbon‐containing devices derived from resorcinol‐formaldehyde resin, GO, and Zn oxide showed better performance than the devices without GO. In particular, the sample that contained 2.5 % of GO in the synthesis showed a specific capacitance of 166.6 F g−1 at 0.5 A g−1 and remained at ∼120 F g−1 at 5 A g−1 current density. Also, it showed interesting energy density values at 0.5 A g−1 (14.8 Wh kg−1) and a power density of 200.7 W kg−1. This reveals that the synthesis process made it possible to obtain composite materials with large surface areas without using a supercritical drying process. The materials can be used in supercapacitor‐type devices with high performance in aqueous electrolytes.
Ökobilanzierung von Beton mit 100 % rezyklierter Gesteinskörnung im Vergleich zu Normalbeton
Authors: Stengel Thorsten , Kustermann Andrea 
Published: September 2024

AbstractDer Bausektor verursacht einen großen Teil des Verbrauchs natürlicher Ressourcen und ist zugleich Quelle der größten Abfallströme. Daher muss es Ziel sein, die Kreislaufwirtschaft im Bausektor zu verbessern. In diesem Zusammenhang wurde am Institut für Material‐ und Bauforschung der Hochschule München die Verwendung rezyklierter Gesteinskörnung über die technischen Baubestimmungen hinaus bis zu 100 % für Konstruktionsbetone untersucht. Die ersten Anwendungen von Beton mit 100 % rezyklierter Gesteinskörnung (100 % R‐Beton) wurden bereits abgeschlossen. Basierend auf den Erkenntnissen aus den Forschungs‐ und Bauprojekten wurden Ökobilanzen erstellt, in denen 100 % R‐Beton (zirkuläres System) mit Normalbeton (lineares System) für den Anwendungsfall C30/37 XC4/XF3 verglichen wurde. Die Ökobilanzen der beiden Produktsysteme wurden in Form von Nomogrammen aufbereitet, sodass Eingangsparameter wie z. B. Transportleistungen angepasst und eine grafische Auswertung zur Ermittlung des GWP durchgeführt werden können. Somit lassen sich basierend auf den durchgeführten Ökobilanzen leicht Empfehlungen für den Einsatz von 100 % R‐Beton bzgl. der Verringerung des GWP in konkreten Anwendungsfällen geben. Dabei können auch andere Zemente nach einer einfachen Umrechnung berücksichtigt werden. Die Analysen zeigen, dass das zirkuläre System bei gleichen Transportleistungen und gleichem Zementgehalt jedoch etwas höherem FM‐Gehalt ein geringfügig niedrigeres GWP aufweist.
Ökobilanzierung von Instandsetzungsvarianten nach TR‐IH in Abhängigkeit vom Schädigungsgrad
Authors: Dauberschmidt Christoph , Stengel Thorsten 
Published: September 2024

AbstractZiel dieser Veröffentlichung ist die vergleichende Ökobilanzierung von Instandsetzungsmaßnahmen nach TR‐IH anhand eines Fallbeispiels. Hierbei wird eine fiktive zweigeschossige Tiefgarage betrachtet, deren Bodenplatte unbeschichtet ist und deren Zwischendecke zahlreiche Trennrisse aufweist. Anhand gängiger Chloriddiffusionsmodelle kann das zeitliche Chlorideindringen in die Bodenplatte und damit die zeitliche Entwicklung des Schädigungsgrades abgeschätzt werden. In Abhängigkeit vom Schädigungsgrad werden zulässige Instandsetzungsverfahren nach TR‐IH ausgewählt und deren erforderliche Einzelmaßnahmen definiert, für die wiederum das Global Warming Potential (GWP) im Rahmen einer Ökobilanzierung berechnet wird. Somit kann abhängig vom Bauteilalter zum Zeitpunkt der Instandsetzung das GWP für verschiedene Instandsetzungsverfahren ermittelt werden. In einem weiteren Schritt werden praxisnahe Annahmen für Betrieb und Wartung getroffen, sodass das GWP der Instandsetzungsverfahren über die Restnutzungsdauer in Abhängigkeit vom Instandsetzungszeitpunkt ermittelt werden kann. Die Berechnungsergebnisse belegen, dass frühzeitige Instandsetzungen zu einem niedrigen GWP führen. Ferner sind behutsame Instandsetzungsverfahren ohne große Eingriffe in die Struktur (Verfahren 7.7, 7.8 oder 8.3) mit besonders geringem GWP verbunden. Vergleicht man KKS (Verfahren 10.1) mit dem Verfahren 7.2, so ist KKS deutlich günstiger bei der Rissinstandsetzung oder wenn über die Betriebsdauer Strom aus erneuerbaren Energien angesetzt wird.
Targeting SRSF10 might inhibit M2 macrophage polarization and potentiate anti‐PD‐1 therapy in hepatocellular carcinoma
Authors: Cai Jialiang , Song Lina , Zhang Feng , Wu Suiyi , Zhu Guiqi , Zhang Peiling , Chen Shiping , Du Junxian , Wang Biao , Cai Yufan , Yang Yi , Wan Jinglei , Zhou Jian , Fan Jia , Dai Zhi 
Published: September 2024

AbstractBackgroundThe efficacy of immune checkpoint blockade therapy in patients with hepatocellular carcinoma (HCC) remains poor. Although serine‐ and arginine‐rich splicing factor (SRSF) family members play crucial roles in tumors, their impact on tumor immunology remains unclear. This study aimed to elucidate the role of SRSF10 in HCC immunotherapy.MethodsTo identify the key genes associated with immunotherapy resistance, we conducted single‐nuclear RNA sequencing, multiplex immunofluorescence, and The Cancer Genome Atlas and Gene Expression Omnibus database analyses. We investigated the biological functions of SRSF10 in immune evasion using in vitro co‐culture systems, flow cytometry, various tumor‐bearing mouse models, and patient‐derived organotypic tumor spheroids.ResultsSRSF10 was upregulated in various tumors and associated with poor prognosis. Moreover, SRSF10 positively regulated lactate production, and SRSF10/glycolysis/ histone H3 lysine 18 lactylation (H3K18la) formed a positive feedback loop in tumor cells. Increased lactate levels promoted M2 macrophage polarization, thereby inhibiting CD8+ T cell activity. Mechanistically, SRSF10 interacted with the 3′‐untranslated region of MYB, enhancing MYB RNA stability, and subsequently upregulating key glycolysis‐related enzymes including glucose transporter 1 (GLUT1), hexokinase 1 (HK1), lactate dehydrogenase A (LDHA), resulting in elevated intracellular and extracellular lactate levels. Lactate accumulation induced histone lactylation, which further upregulated SRSF10 expression. Additionally, lactate produced by tumors induced lactylation of the histone H3K18la site upon transport into macrophages, thereby activating transcription and enhancing pro‐tumor macrophage activity. M2 macrophages, in turn, inhibited the enrichment of CD8+ T cells and the proportion of interferon‐γ+CD8+ T cells in the tumor microenvironment (TME), thus creating an immunosuppressive TME. Clinically, SRSF10 could serve as a biomarker for assessing immunotherapy resistance in various solid tumors. Pharmacological targeting of SRSF10 with a selective inhibitor 1C8 enhanced the efficacy of programmed cell death 1 (PD‐1) monoclonal antibodies (mAbs) in both murine and human preclinical models.ConclusionsThe SRSF10/MYB/glycolysis/lactate axis is critical for triggering immune evasion and anti‐PD‐1 resistance. Inhibiting SRSF10 by 1C8 may overcome anti‐PD‐1 tolerance in HCC.