bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydatid Cyst of the Parotid Gland: A Rare Location
Authors: Erdur Omer , Colpan Bahar , Sofuoglu Fuad , Kibar Ertugrul 
Published: October 2017

Abstract
Hydatid disease of the parotid gland is a very rare entity and may be easily overlooked in the diagnosis of parotid masses. Although Turkey remains an endemic area for echinococcosis, involvement of the parotid gland is extremely rare. A 26-year-old man presented with primary parotid gland mass without any other organ involvement. During the first surgery, the cyst was perforated accidentally and in a short time recurrence was occurred. Maximum attention was given for the second surgery for total removal without damaging the cyst with medical treatment. The clinicians should take hydatid disease of parotid gland into consideration and great care must be given for not damaging the capsule of the cystic tumors in order to prevent recurrences.
One-Year Survival after Inhospital Cardiac Arrest—Does Prearrest Sepsis Matter?
Authors: Koivikko Pia , Arola Olli , Inkinen Outi , Tallgren Minna 
Published: October 2017

ABSTRACT

Aim:
Cardiac arrest is not a common complication of sepsis, although sepsis has been recognized as one condition behind cardiac arrest. Our aim was to evaluate the prevalence of sepsis among patients with inhospital cardiac arrest (IHCA), and to determine if sepsis is associated with inferior outcome after IHCA.

Methods:
All consecutive emergency team dispatches in Turku University Hospital in 2011 to 2014 (n = 607) were retrospectively reviewed to identify the patients undergoing cardiopulmonary resuscitation (CPR) for IHCA (n = 301). The patient records were reviewed for the criteria of severe sepsis, organ dysfunction, and chronic comorbidities before IHCA. Outcome was followed for 1 year.

Results:
The criteria for prearrest severe sepsis were met by 83/301 (28%) of the patients, and 93/301 (31%) had multiorgan dysfunction (3 or more organ systems). The patients with severe sepsis had higher mortality than those without severe sepsis, increasing from 30-day mortalities of 63/83 (76%) and 151/218 (69%), respectively (P = 0.256), to 1-year mortalities of 72/83 (87%) and 164/218 (75%), respectively (P = 0.030). Emergency admission, age, immunosuppression, DM, multiorgan dysfunction, and a nonshockable rhythm were independent predictors of 1-year mortality by multivariate logistic regression analysis. Six out of 83 patients with severe sepsis before IHCA (7%) survived 1 year with good neurological outcome (CPC scale 1).

Conclusions:
A high proportion of patients with IHCA have sepsis and multiorgan dysfunction, and their prognosis is worse than the prognosis of patients with IHCA in general.
Comparisons of Traditional Metabolic Markers and Compensatory Reserve as Early Predictors of Tolerance to Central Hypovolemia in Humans
Authors: Schiller Alicia M. , Howard Jeffrey T. , Lye Kristen R. , Magby Christian G. , Convertino Victor A. 
Published: October 2017

ABSTRACT
Circulatory shock remains a leading cause of death in both military and civilian trauma. Early, accurate and reliable prediction of decompensation is necessary for the most efficient interventions and clinical outcomes. Individual tolerance to reduced central blood volume can serve as a model to assess the sensitivity and specificity of vital sign measurements. The compensatory reserve (CRM) is the measurement of this capacity. Measurements of muscle oxygen saturation (SmO2), blood lactate, and end tidal CO2 (EtCO2) have recently gained attention as prognostic tools for early assessment of the status of patients with progressive hemorrhage, but lack the ability to adequately differentiate individual tolerance to hypovolemia. We hypothesized that the CRM would better predict hemodynamic decompensation and provide greater specificity and sensitivity than metabolic measures. To test this hypothesis, we employed lower body negative pressure on healthy human subjects until symptoms of presyncope were evident. Receiver operating characteristic area under the curve (ROC AUC), sensitivity, and specificity were used to evaluate the ability of CRM, partial pressure of oxygen (pO2), partial pressure of carbon dioxide (pCO2), SmO2, lactate, EtCO2, potential of hydrogen (pH), base excess and hematocrit (Hct) to predict hemodynamic decompensation. The ROC AUC for CRM (0.94) had a superior ability to predict decompensation compared with pO2 (0.85), pCO2 (0.62), SmO2 (0.72), lactate (0.57), EtCO2 (0.74), pH (0.55), base excess (0.59), and Hct (0.67). Similarly, CRM also exhibited the greatest sensitivity and specificity. These findings support the notion that CRM provides superior detection of hemodynamic compensation compared with commonly used clinical metabolic measures.
Inhaled Loxapine for Agitation in Intoxicated Patients: A Case Series
Authors: Roncero Carlos , Ros-Cucurull Elena , Palma-Álvarez Raúl Felipe , Abad Alfonso Carlos , Fadeuilhe Christian , Casas Miquel , Grau-López Lara 
Published: October 2017

Objectives
Episodes of agitation are frequent in intoxicated patients who have a substance use disorder, a psychiatric disorder or both (dual diagnosis). For managing the agitation, it is necessary to act promptly in a safe environment and addressing any underlying etiology. Inhaled loxapine improves symptoms of agitation in adults with psychiatric disorders (eg, schizophrenia) within 10 minutes of administration. Recently, some reports have documented the usefulness of loxapine in dual diagnoses patients with agitation. However, the efficacy of loxapine in intoxicated patients has not been deeply addressed.

Methods
This report describes a case series of 12 patients (with addiction or dual disorder) who received inhaled loxapine for symptoms of psychomotor agitation during intoxication with different substances (eg, alcohol, cannabis, or cocaine) at 1 center in Spain.

Results
Data from 12 patients were reviewed, 5 patients were attended at the emergency room, 4 at the addiction and dual diagnosis unit, and 3 were treated during hospitalization for detoxification. All patients were under effects of substances. They had substance use disorder (including cannabis, cocaine, alcohol, hypnotics, and hallucinogens), and almost all (90%) presented 1 or more psychiatric disorders. One dose of inhaled loxapine was effective in 9 patients (75%), and in 3 patients, a second dose was required. Only mild dizziness was reported in 1 patient after the second dose.

Conclusions
The acute agitation was effectively and quickly managed with inhaled loxapine in all intoxicated patients and enabled the appropriate clinical evaluation of the agitated state and the patient's management.
Assessment of owner-directed aggressive behavioural tendencies of dogs in situations of possession and manipulation
Authors: Bálint Anna , Rieger Gabriella , Miklósi Ádám , Pongrácz Péter 
Published: October 2017

Excessive aggression is a common behaviour problem in dogs that can have various destructive effects on the affected people and the implicated dog. Aggressive behaviour directed towards the owner or other family members is one of the most frequently occurring aggressive phenotypes. Here, we examine the reliability of a short questionnaire assessing aggressive behaviours by two, contextually different behavioural tests: ‘take away bone’ and ‘roll over’. Based on dogs' behaviour in the tests, we sorted dogs (
N
= 93) in two groups for each test, namely a less and a more disobedient/resistant group. The two principal components obtained in our questionnaire—‘obedient’ and ‘aggressive towards owner’—showed significant differences between the behaviour groups. While dogs in the less disobedient/resistant groups had significantly higher ‘obedient’ and significantly lower ‘aggressive towards owner’ scores, dogs in the more disobedient/resistant groups had significantly higher ‘aggressive towards owner’ and significantly lower ‘obedient’ scores. Dogs' age, sex and neuter/spay status expressed their effect through interactions. Males, young dogs and intact dogs were less ‘obedient’ than older ones, while resistant spayed/neutered dogs were more aggressive towards the owner. The questionnaire used is a safe, easy to deploy and time-efficient tool to reliably assess certain owner-directed aggressive tendencies of family dogs.
MAGI: A method for metabolite, annotation, and gene integration
Authors: Erbilgin Onur , Rübel Oliver , Louie Katherine B. , Trinh Matthew , Raad Markus de , Wildish Tony , Udwary Daniel W. , Hoover Cindi A. , Deutsch Samuel , Northen Trent R. , Bowen Benjamin P. 
Published: October 2017

AbstractMetabolomics is a widely used technology for obtaining direct measures of metabolic activities from diverse biological systems. However, ambiguous metabolite identifications are a common challenge and biochemical interpretation is often limited by incomplete and inaccurate genome-based predictions of enzyme activities (i.e. gene annotations). Metabolite, Annotation, and Gene Integration (MAGI) generates a metabolite-gene association score using a biochemical reaction network. This is calculated by a method that emphasizes consensus between metabolites and genes via biochemical reactions. To demonstrate the potential of this method, we applied MAGI to integrate sequence data and metabolomics data collected from Streptomyces coelicolor A3(2), an extensively characterized bacterium that produces diverse secondary metabolites. Our findings suggest that coupling metabolomics and genomics data by scoring consensus between the two increases the quality of both metabolite identifications and gene annotations in this organism. MAGI also made biochemical predictions for poorly annotated genes that were consistent with the extensive literature on this important organism. This limited analysis suggests that using metabolomics data has the potential to improve annotations in sequenced organisms and also provides testable hypotheses for specific biochemical functions. MAGI is freely available for academic use both as an online tool at https://magi.nersc.gov and with source code available at https://github.com/biorack/magi.
A population phylogenetic view of mitochondrial heteroplasmy
Authors: Wilton Peter R. , Zaidi Arslan , Makova Kateryna , Nielsen Rasmus 
Published: October 2017

AbstractThe mitochondrion has recently emerged as an active player in a myriad of cellular processes. Additionally, it was recently shown that more than 200 diseases are known to be linked to variants in mitochondrial DNA or in nuclear genes interacting with mitochondria. This has reinvigorated interest in its biology and population genetics. Mitochondrial heteroplasmy, or genotypic variation of mitochondria within an individual, is now understood to be common in humans and important in human health. However, it is still not possible to make quantitative predictions about the inheritance of heteroplasmy and its proliferation within the body, partly due to the lack of an appropriate model. Here, we present a population-genetic framework for modeling mitochondrial heteroplasmy as a process that occurs on an ontogenetic phylogeny, with genetic drift and mutation changing heteroplasmy frequencies during the various developmental processes represented in the phylogeny. Using this framework, we develop a Bayesian inference method for inferring rates of mitochondrial genetic drift and mutation at different stages of human life. Applying the method to previously published heteroplasmy frequency data, we demonstrate a severe effective germline bottleneck comprised of the cumulative genetic drift occurring between the divergence of germline and somatic cells in the mother and the separation of germ layers in the offspring. Additionally, we find that the two somatic tissues we analyze here undergo tissue-specific bottlenecks during embryogenesis, less severe than the effective germline bottleneck, and that these somatic tissues experience little additional genetic drift during adulthood. We conclude with a discussion of possible extensions of the ontogenetic phylogeny framework and its possible applications to other ontogenetic processes in addition to mitochondrial heteroplasmy.
Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk
Authors: Reshef Yakir A , Finucane Hilary K , Kelley David R , Gusev Alexander , Kotliar Dylan , Ulirsch Jacob C , Hormozdiari Farhad , Nasser Joseph , O’Connor Luke , van de Geijn Bryce , Loh Po-Ru , Grossman Shari , Bhatia Gaurav , Gazal Steven , Palamara Pier Francesco , Pinello Luca , Patterson Nick , Adams Ryan P , Price Alkes L 
Published: October 2017

AbstractBiological interpretation of GWAS data frequently involves analyzing unsigned genomic annotations comprising SNPs involved in a biological process and assessing enrichment for disease signal. However, it is often possible to generate signed annotations quantifying whether each SNP allele promotes or hinders a biological process, e.g., binding of a transcription factor (TF). Directional effects of such annotations on disease risk enable stronger statements about causal mechanisms of disease than enrichments of corresponding unsigned annotations. Here we introduce a new method, signed LD profile regression, for detecting such directional effects using GWAS summary statistics, and we apply the method using 382 signed annotations reflecting predicted TF binding. We show via theory and simulations that our method is well-powered and is well-calibrated even when TF binding sites co-localize with other enriched regulatory elements, which can confound unsigned enrichment methods. We further validate our method by showing that it recovers known transcriptional regulators when applied to molecular QTL in blood. We then apply our method to eQTL in 48 GTEx tissues, identifying 651 distinct TF-tissue expression associations at per-tissue FDR < 5%, including 30 associations with robust evidence of tissue specificity. Finally, we apply our method to 46 diseases and complex traits (averageN= 289,617) and identify 77 annotation-trait associations at per-trait FDR < 5% representing 12 independent TF-trait associations, and we conduct gene-set enrichment analyses to characterize the underlying transcriptional programs. Our results implicate new causal disease genes (including causal genes at known GWAS loci), and in some cases suggest a detailed mechanism for a causal gene’s effect on disease. Our method provides a new way to leverage functional data to draw inferences about disease etiology.
Advertising literacy training
Authors: De Jans Steffi , Hudders Liselot , Cauberghe Veroline 
Published: October 2017

PurposeThis paper aims to examine the immediate and delayed effects of advertising literacy training on children’s cognitive advertising literacy for an embedded advertising format, product placement and, subsequently, its persuasive effects. In addition, this study explored whether this effect is moderated by children’s general advertising liking. The study also investigated whether the effects of training were dependent on children’s ages.Design/methodology/approachThe present study is conducted using a three (training session: control condition vs advertising literacy training with immediate ad exposure vs advertising literacy training with ad exposure after one week) by two (age: 7-8 years vs 10-11 years) between-subjects experimental design.FindingsThe results of the experimental study showed that advertising literacy training increases children’s cognitive advertising literacy for product placement for both younger and older children and both immediately and delayed (measured after one week). In addition, cognitive advertising literacy had an influence on the effectiveness of product placement (i.e. purchase request) when children’s general ad liking was low, though not when it was high. No moderating effects of age were found.Practical implicationsThis study shows that advertising literacy training sessions can improve children’s cognitive advertising literacy for non-traditional, embedded advertising formats.Originality/valueThis study is one of the first to examine and confirm the immediate and delayed effects of advertising literacy training sessions on children’s cognitive advertising literacy for non-traditional advertising formats.
Adaptations in traditional courtyard houses in Baghdad, Iraq
Authors: Agha Rand H.M. , Kamara John M. 
Published: October 2017

Purpose
The purpose of this paper is to investigate the adaptations that have been made to traditional courtyard houses (TCHs) in Baghdad, Iraq. The aim is to develop an understanding of various factors in the adaptation of these buildings to suit contemporary lifestyles, which will contribute to the wider field of building adaptability.

Design/methodology/approach
Empirical evidence was collected through case studies of 12 TCHs in the Al-Kadhimiya area of Baghdad, which involved a physical survey of buildings and semi-structured interviews with 24 occupants.

Findings
Case study analysis show that building adaptability involves both a change to physical spaces and also to lifestyles; with the latter being more likely when there are limitations in how much change can be made to the physical structure.

Research limitations/implications
The focus of this research is mainly on users’ adaptation of spaces and therefore does not consider the full range of stakeholders involved in the adaptation process. The findings also only apply to the cases considered and may not be applicable to other house types or locations.

Originality/value
Studies on building adaptability mostly focus on the ease of change to the building fabric, although the role of users is acknowledged. This study provides insights into the complexity and variety of changes that users can make, which are influenced by lifestyles and driven by the need for comfort. These insights are represented in an adaptation model, which can serve as a basis for further research.
Adapting the design of a new care home development for a changing climate
Authors: Botti Andrea , Ramos Marylis 
Published: October 2017

Purpose
In the light of projected climate change impacts on buildings and their occupants, climate change adaptation for built environment to climate change is crucial. The risk of overheating is a key concern, particularly given its effect on heat-related health problems for elderly people. The purpose of this paper is to propose, test, and evaluate the strategies for climate change adaptation to minimise present and future risks of overheating for a new purpose-built care home and extra care accommodation near York.

Design/methodology/approach
The overheating risk was assessed through dynamic simulations, using probabilistic projections for 2030s, 2050s and 2080s. Suitable adaptation measures were tested and compared using industry metrics. A stakeholders’ workshop compared the relative effectiveness of the identified measures and made a broader evaluation using defined criteria. Highest-ranked measures were combined into “adaptation packages” in order to populate adaptation timelines for the project.

Findings
Results show that the original design presents a severe overheating risk. Increasing thermal mass and slightly improving ventilation are adequate for the 2030s; however solar shading and further improvements of ventilation are necessary for the 2050s. The stress test revealed that even the most effective passive measures combined would be insufficient to maintain comfortable conditions by the 2080s, and mechanical cooling would be needed.

Originality/value
The comparative analysis of adaptation measures using normalised CIBSE TM52 criteria improved risk communication and engagement with the client and the design team. The integration of quantitative and qualitative evaluation criteria led to an appropriate and timely strategy for adaptation.
Gated communities in Ankara: are they a tool of social segregation?
Authors: Alkan-Gökler Leyla 
Published: October 2017

Purpose
Gated communities, surrounded by walls or fences, have emerged as a new trend in almost all cities in Turkey, and are homogenous in terms of the socioeconomic status of their occupants. Within these communities, several facilities and services are provided that are available only to the residents, with restrictions on access from the outside, and this has led to criticisms of social segregation. This study aims to analyze the impact of these communities on social segregation in Ankara, through two different surveys aimed at investigating the attitudes of the residents of local neighborhoods and gated communities toward each other.

Design/methodology/approach
This paper analyzes how the process of gating has affected social segregation in Ankara through two separate surveys: with the residents of gated communities and with the residents of local neighborhoods around these gated communities.

Findings
The study revealed that the residents of gated communities tended to have a positive view of the residents of local neighborhoods. In contrast, the responses of the local residents show evidence of feelings of social segregation, based on the presence of the high walls, fences and guards that are in place to keep them out of the community.

Originality/value
This study shows that, although segregation from the rest of the society is not the main reason for gating, the emergence of gated communities in Ankara leads inevitably to a socially and economically segregated city in which local residents feel excluded from these gated areas.
Mall image, shopping well-being and mall loyalty
Authors: Mohammad Shafiee Majid , Es-Haghi Sayyed Mohammad Sadiq 
Published: October 2017

Purpose
This study was carried out to identify mall image dimensions, analyse and discuss how shopping well-being is influenced by mall image and impacts on mall loyalty with the moderating role of gender differences. Besides, the relationship between hedonic value (HV) and utilitarian value (UV) on shopping well-being are investigated. The paper aims to discuss these issues.

Design/methodology/approach
Through a questionnaire, data were obtained from shoppers at the biggest and the most remarkable malls in Tehran that has a high level of brand awareness. A two-stage method of structural equation modelling was used for testing the hypotheses.

Findings
The results show that shopping well-being is affected by mall image and HV but not by UV. In addition, as indicated in previous researches, this study supports the idea that shopping well-being influences mall loyalty. In other words, it is argued that shopping well-being is more about pleasure and fun than doing task-oriented activities.

Originality/value
Most of the mall image dimensions overlapped each other, therefore the purpose of this research is to choose and introduce the best and the most comprehensive combination of those dimensions. Also, in spite of the recent emergence of the shopping well-being concept, it has proved to be delicate in the Iranian context through value, consumer well-being, consumption experiences and sociological life space theories in the quantitative method. In addition, this study shows that shopping well-being is a subjective well-being. This is in contrast to what the common Islamic philosophers opine. Additionally, not only did it propose how to make shoppers more loyal through shopping well-being, but it also discussed the role of gender difference on the subject of shopper loyalty phenomenon. More importantly, this study enables other researchers to investigate cultural differences in this region and make it possible to compare Middle Eastern Countries, especially Iran, to other countries.