bluuebunny/crossref_metadata_2025_split huggingface dataset:
Right knee ACL, PCL and MCL reconstruction with sports-related anxiety
Authors: Nulkar Avnee , Najamus-Saqib Khan Kazi 
Published: October 2024

Introduction: JM, a 20-year-old male professional ice hockey player, presented with a 2-week history of lack of range of motion, weakness, and pain in his right knee, after a 2-year post-medical collateral ligament repair of the right knee and 3 year-post anterior cruciate ligament, posterior cruciate ligament and medial collateral ligament reconstruction of the right knee.
Case Description: In the course of history taken, it was revealed that 5 months prior to admission the patient had been informed by a psychiatrist that he had sport-related anxiety. With an unremarkable psychiatric history prior to age 18, the competitive nature of his sports career in addition to financial pressure may have contributed to his sports-related anxiety. His examination findings were consistent with a diagnosis of complete tears of the right anterior cruciate ligament and posterior cruciate ligament along with grade III medial collateral ligament injury.
Discussion: The biopsychosocial model was used to explicate JM's case. JM's current injuries prompted reconstruction of the anterior cruciate, posterior cruciate, and medial collateral ligaments. Psychologically, JM's sports-related anxiety is not a rare phenomenon as recent studies have discovered an increased risk of sports-related anxiety amongst young professional athletes. Sports-related anxiety, along with competitive trait anxiety, may be factors that contribute to sports injury occurrence. Other psychological stressors can add to sports-related or competitive trait anxiety, further increasing the risk of sports injury reoccurrence.
Summary: JM was admitted for a right knee open medial collateral ligament repair with internal bracing, anterior cruciate ligament reconstruction, posterior cruciate ligament reconstruction, and platelet rich plasma injection. As part of a holistic patient-centered treatment plan, a referral to psychiatry was made to address JM's sports-related anxiety with the goal of decreasing future risk of sports injury.
Patient's Consent Obtained: Yes
A systematic review upon the online content provided for self-management of diabetes
Authors: Najamus-Saqib Khan Kazi , Nulkar Avnee 
Published: October 2024

Background: Diabetes is a major illness that requires appropriate education in order to increase one's understanding of self-management. With the advancement of the internet, the proliferation of online health-related content in supporting the management of chronic illness like diabetes has been ongoing; however, little is understood on the sort of acceptable and/or effective information attainable online.
Objective: The aim of this review is to evaluate the current literature in hindsight of online management in diabetes whilst establishing the effectiveness of online management tools, the quality of the online information, and the methods of obtaining online information.
Methods: A series of systematic searches of online databases were conducted in accordance with strictly defined inclusion and exclusion criteria relevant to the research question. Additionally, an evidence-based literature (EBL) checklist tool was used to assess the methodological and reporting quality of each study. Each article was peer-reviewed and screened for any biases.
Results: A result of 11 electronic searches were critically appraised using the EBL appraisal checklist tool and all were found to have overall validity. The results indicate an increase use of online technology to empower an understanding of one's own health. Web-based tools like social media were useful in promoting the management of diabetes but were not able to provide quality information.
Conclusion: Current research indicates the need for more investigation and future development of readily accessible and qualitative information in order to support the self-management of diabetes.
Cross-validation of methods for the quantitative determination of phenazepam and its active metabolite in human blood plasma at various extractions
Authors: Platova A. I. , Kuzmin I. I. , Ivaschenko D. V. , Miroshnichenko I. I. 
Published: October 2024

Introduction. In conducting of therapeutic drug monitoring (TDM), often such situation arises where the drug concentration has measured by different methods or in different laboratories. To combine and analyze the data obtained with different methods, it is necessary to perform cross-validation procedure. Insufficient attention is paid to the statistical approaches used for this purpose.Aim. Performing cross-validation of different analytical methods for the quantitative determination of phenazepam (PHEN) and 3-hydroxyphenazepam (3-OH-PHEN) using the Bland – Altman analysis.Materials and methods. PHEN and 3-OH-PHEN concentrations in the blood plasma of patients (n = 100) with alcohol withdrawal syndrome were measured using high-performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The quantification of both analytes in each sample was measure twice by two different methods: solid phase extraction (SPE) and supported liquid extraction (SLE). Both methods have been fully validated before the experiment began. Cross-validation was performed at the end of the experiment using data from study samples. The Bland – Altman analysis was used to evaluate accuracy and precision. Deming regression was also used to identify a systematic error between measurement results.Results and discussion. The regression equations have been obtained between concentrations both analytes measured by different sample preparation methods. 95 % confidence intervals (CI) of the regression coefficients of both equations included one, and 95 % CI of the intercepts included zero. 95 % CI of the geometric mean of the individual SLE/SPE ratios was within the acceptable range (0.87; 1.15). These results confirm the absence of the influence of quantitative methods on the measurement of both analytes concentration. 66.7 % CI of the percent difference between two measurements was within acceptable limits (–0.2; 0.2), not exceeding 20 % of the range of their mean value. This confirms the acceptable precision between the methods. The estimated CIs were displayed in the Bland – Altman plots.Conclusion. The statistical approaches used in the work have confirmed the reproducibility of the results of different sample preparation methods. In addition to cross-validation, the statistical algorithm from this paper using Bland – Altman analysis can be successfully employed to assess accuracy and precision during bioanalytical method validation and evaluation of the acceptance of analytical runs, as well as to determine the level of reproducibility of incurred samples.
Efficacy and safety of different drugs for the treatment of bacterial vaginosis: a systematic review and network meta-analysis
Authors: Fan Yuxin , Gu Yanhong , Xian Yi , Li Qinya , He Youli , Chen Kaiyang , Yu Hui , Deng Huan , Xiong Li , Cui Zhiwei , Yang Yang , Xiang Yin 
Published: October 2024

ObjectiveBacterial vaginosis is a disease caused by vaginal microecology disorder, which seriously affects female health. At present, there are many drugs to treat BV, and this study aims to compare the efficacy and safety of multiple drugs for BV through a network meta-analysis (NMA).MethodsAll studies were sourced from PubMed and Embase databases from the establishment date to April 13, 2023. We evaluated the clinical cure success rate and adverse effects (abnormal increase in vaginal discharge, external genital irritation, and vulvar itching) and performed subgroup analyses of the clinical cure success rate for different modes of administration. All statistical analyses were performed using R and STATA 14.0 software for network meta-analysis.ResultsWe included 42 studies that met the criteria, involving a total of 8382 patients. Network meta-analysis results showed that metronidazole and secnidazole had a higher rate of adverse reactions than placebo (RR 7.06; 95%-CI 2.61-19.10, RR 4.03; 95%-CI 1.63-9.98), the adverse reaction rate of probiotics group was lower than that of metronidazole group (RR 0.44; 95%-CI 0.21-0.93). The clinical cure rate of oral ornidazole was better than clindamycin (RR 16.08; 95%-CI 1.72-150.47), Secnidazole (RR 8.17; 95%-CI 1.66-40.25) and probiotics. Direct meta-analysis results showed that ornidazole had a better clinical cure rate than Secnidazole (RR 1.22; 95%-CI 1.10-1.34), oral ornidazole had a better clinical cure rate than Secnidazole (RR 1.23; 95%-CI 1.11-1.36). The clinical cure rate of vaginal application of sucrose was better than metronidazole (RR 1.12; 95%-CI 1.03-1.21) and metronidazole had a lower clinical cure rate than probiotics (RR 0.68; 95%-CI 0.52-0.88).ConclusionsThe results of this systematic review and network meta-analysis suggest that ornidazole may be an effective alternative for the treatment of BV, and that sucrose and probiotics are potential BV treatments that need to be validated by more high-quality clinical studies in the future.
Causal relationship between Women’s reproductive traits and postpartum depression: a multivariate mendelian randomization analysis
Authors: Kang Zhen , Wu Qingming , Cao Jianan , Zhu Mohao , You Zhaoling , Li Dandan , Liu Weiai 
Published: October 2024

PurposeThe relationship between women’s reproductive traits and postpartum depression (PPD) has not been clarified. We reveal the association between genetically predicted modifiable women’s reproductive traits and PPD using two-sample Mendelian randomization (MR).MethodsWe used genome-wide association studies (GWASs) to obtain instrumental variables (IVs) of 9 women’s reproductive traits. Univariate and multivariate MR analyses were used to examine the association between traits and the risk of PPD (13,657 cases and 236,178 controls). The primary causal effect assessment employed the IVW method. Heterogeneity was assessed using Cochran’s Q test. Multiple horizontal effects were assessed using the MR-PRESSO and MR-Egger intercept. Leave-one-out and LASSO regression analyses were used to check the robustness of the UVMR and MVMR results, respectively.ResultsIn the UVMR result, genetic prediction showed that age at first sexual intercourse (AFS) (OR = 0.474, 95% CI 0.396–0.567; p = 4.6 × 10–16), age at first birth (AFB) (OR = 0.865, 95% CI 0.805–0.930; p = 8.02 × 10−5), and age at last live birth (ALLB) (OR = 0.296, 95% CI 0.138–0.636; p = 0.002) were significantly inversely associated with PPD, while a higher lifetime number of sexual partners (LNSP) (OR = 1.431, 95% CI 1.009–2.031; p = 0.045) and a greater number of spontaneous miscarriages (OR = 1.519, 95% CI 1.021–2.262; p = 0.039) are suggested to be associated with an increased risk of PPD. In the MVMR result, only AFB (OR = 0.804, 95% CI 0.661–0.978; p = 0.029) retained a direct causative relationship with PPD.ConclusionThe study indicates that AFB is a significant risk factor for PPD. Furthermore, the likelihood of developing PPD appears to decrease with increasing gestational age at the time of the first childbirth.
Circulating hsa-miR-320a and its regulatory network in type 1 diabetes mellitus
Authors: Nizam Rasheeba , Malik Md Zubbair , Jacob Sindhu , Alsmadi Osama , Koistinen Heikki A. , Tuomilehto Jaakko , Alkandari Hessa , Al-Mulla Fahd , Thanaraj Thangavel Alphonse 
Published: October 2024

IntroductionIncreasing evidence from human and animal model studies indicates the significant role of microRNAs (miRNAs) in pancreatic beta cell function, insulin signaling, immune responses, and pathogenesis of type 1 diabetes (T1D).MethodsWe aimed, using next-generation sequencing, to screen miRNAs from peripheral blood mononuclear cells of eight independent Kuwaiti-Arab families with T1D affected siblings, consisting of 18 T1D patients and 18 unaffected members, characterized by no parent-to-child inheritance pattern.ResultsOur analysis revealed 20 miRNAs that are differentially expressed in T1D patients compared with healthy controls. Module-based weighted gene co-expression network analysis prioritized key consensus miRNAs in T1D pathogenesis. These included hsa-miR-320a-3p, hsa-miR-139-3p, hsa-miR-200-3p, hsa-miR-99b-5p and hsa-miR-6808-3p. Functional enrichment analysis of differentially expressed miRNAs indicated that PI3K-AKT is one of the key pathways perturbed in T1D. Gene ontology analysis of hub miRNAs also implicated PI3K-AKT, along with mTOR, MAPK, and interleukin signaling pathways, in T1D. Using quantitative RT-PCR, we validated one of the key predicted miRNA-target gene-transcription factor networks in an extended cohort of children with new-onset T1D positive for islet autoantibodies. Our analysis revealed that hsa-miR-320a-3p and its key targets, including PTEN, AKT1, BCL2, FOXO1 and MYC, are dysregulated in T1D, along with their interacting partners namely BLIMP3, GSK3B, CAV1, CXCL3, TGFB, and IL10. Receiver Operating Characteristic analysis highlighted the diagnostic potential of hsa-miR-320a-3p, CAV1, GSK3B and MYC for T1D.DiscussionOur study presents a novel link between hsa-miR-320a-3p and T1D, and highlights its key regulatory role in the network of mRNA markers and transcription factors involved in T1D pathogenesis.
Demographic-based disparities in outcomes for adults with central line-associated bloodstream infections in the United States: a National Inpatient Sample database study (2016–2020)
Authors: Dix Marie , Belleville Troy , Mishra Anjali , Walters Ryan W. , Millner Paul , Jabbar Ali Bin Abdul , Tauseef Abubakar 
Published: October 2024

IntroductionCentral line-associated bloodstream infections (CLABSI) are prevalent and preventable hospital-acquired infections associated with high morbidity and costs. Disparities based on race, ethnicity, and hospital factors remain underexplored. This study compares cost, length of stay, and mortality for adults with CLABSI by race-ethnicity, hospital location-teaching status, and geographic region in the United States using data from the National Inpatient Sample (NIS) database from 2016 to 2020.MethodsThe hospitalization cohort included adults diagnosed with CLABSI, excluding those with primary CLABSI diagnoses, cancer, immunosuppressed states, or neonatal conditions. Primary outcomes were in-hospital mortality, length of stay, and hospital costs, adjusted to mid-year 2020 US dollars. Independent variables included race-ethnicity, hospital location-teaching status, and geographic region. All analyses accounted for NIS sampling design.ResultsFrom 2016 to 2020, there were approximately 19,835 CLABSI hospitalizations. The overall in-hospital mortality rate was 9.1%, with a median hospital stay of 16.9 days and median cost of $44,810. Hispanic patients experienced significantly higher mortality, longer length of stay, and higher costs compared to non-Hispanic Black and White patients. Urban teaching hospitals had longer stays and higher costs than rural and urban non-teaching hospitals. Regionally, the Northeast and West had higher costs and longer stays than the Midwest and South, but mortality rates did not differ significantly.ConclusionThis study highlights significant disparities in CLABSI outcomes based on demographic factors. Addressing these disparities is crucial for improving CLABSI management and healthcare equity. Further research should explore the underlying causes of these differences to inform targeted interventions.
Effect of air pollution on the global burden of cardiovascular diseases and forecasting future trends of the related metrics: a systematic analysis from the Global Burden of Disease Study 2021
Authors: Mao Qingsong , Zhu Xiaoyi , Zhang Xinyi , Kong Yuzhe 
Published: October 2024

BackgroundThis study assesses the worldwide cardiovascular disease (CVD) burden attributed to air pollution, utilizing data from the Global Burden of Disease Study 2021.MethodsWe explored the impact of air pollution on CVDs globally, regionally, and nationally, while considering correlations with age, gender, and socio-demographic index (SDI). A decomposition analysis was conducted to discern the contributions of aging, population growth, and epidemiological shifts to the changes in disability-adjusted life years (DALYs) from 1990 to 2021. Additionally, an ARIMA model was used to forecast the future CVD burden through 2050.ResultsIn 2021, air pollution was responsible for approximately 2.46 million deaths and 58.3 million disability-adjusted life years (DALYs) attributable to CVDs, with a discernible decrease over the period studied. The greatest impacts were observed in individuals aged 75–79 and over 80, particularly among males. The decomposition analysis indicated that shifts in epidemiology were the primary factors driving these changes. Future projections suggest potential increases in mortality and DALY rates in regions with low and high-middle SDI, alongside rising age-standardized death and mortality rates in high SDI areas.ConclusionThese findings underscore the urgency of implementing targeted CVD prevention and air pollution control strategies to mitigate the impact on public health.
Sports-ACtrans Net: research on multimodal robotic sports action recognition driven via ST-GCN
Authors: Lu Qi 
Published: October 2024

IntroductionAccurately recognizing and understanding human motion actions presents a key challenge in the development of intelligent sports robots. Traditional methods often encounter significant drawbacks, such as high computational resource requirements and suboptimal real-time performance. To address these limitations, this study proposes a novel approach called Sports-ACtrans Net.MethodsIn this approach, the Swin Transformer processes visual data to extract spatial features, while the Spatio-Temporal Graph Convolutional Network (ST-GCN) models human motion as graphs to handle skeleton data. By combining these outputs, a comprehensive representation of motion actions is created. Reinforcement learning is employed to optimize the action recognition process, framing it as a sequential decision-making problem. Deep Q-learning is utilized to learn the optimal policy, thereby enhancing the robot's ability to accurately recognize and engage in motion.Results and discussionExperiments demonstrate significant improvements over state-of-the-art methods. This research advances the fields of neural computation, computer vision, and neuroscience, aiding in the development of intelligent robotic systems capable of understanding and participating in sports activities.
Effect of intermittent theta burst stimulation on upper limb function in stroke patients: a systematic review and meta-analysis
Authors: Lu Junyue , Huang Jiahao , Ye Anqi , Xie Chen , Bu Pan , Kang Jiliang , Hu Jiaxuan , Wen Youliang , Huang Haoyuan 
Published: October 2024

BackgroundStroke is a serious health issue that affects individuals, families, and society. Particularly, the upper limb dysfunction caused by stroke significantly reduces the quality of life for patients and may lead to psychological issues. Current treatment modalities are not fully effective in helping patients regain upper limb motor function to optimal levels. Therefore, there is an urgent need to explore new rehabilitation methods to address this issue.ObjectiveThe purpose of this meta-analysis and systematic review is to explore the effects of intermittent theta burst stimulation (iTBS) on upper limb function in stroke patients.MethodsWe searched PubMed, Cochrane Library, Embase, Web of Science, PEDro and China National Knowledge Internet as of April 8, 2024. Retrieved a total of 100 articles. Standardized mean differences (SMDs) and 95% confidence intervals (CI) were calculated.ResultsThe study included a total of 9 trials and involved 224 patients. The results demonstrate that compared to the control group, iTBS therapy significantly improved Fugl-Meyer assessment-upper extremity (FMA-UE) scores (SMD = 0.88; 95% CI = 0.11–1.66; P = 0.03, I2 = 84%), Action Research Arm Test (ARAT) scores (SMD = 0.83; 95% CI = 0.16–1.50; P = 0.02, I2 = 57%), and Barthel Index (BI) scores (SMD = 0.93; 95% CI = 0.53–1.32; P &lt; 0.0001, I2 = 0%) in stroke patients.ConclusionsThe comprehensive evidence suggests that iTBS has superior effects in improving upper limb function and activities of daily living in stroke patients.
Causal relationship between metabolites and embolic stroke: based on Mendelian randomization and metabolomics
Authors: Hang Ying , Chen Zanhao , Ren Jiayi , Wang Yu , Zhu Kangle , Zhu Qianhong 
Published: October 2024

PurposeThis research employed Mendelian randomization (MR) methods to explore whether metabolites are causally associated with embolic stroke of undetermined source (ESUS).MethodsGenome-Wide Association Study (GWAS) data regarding metabolites and ESUS were downloaded from the database. Metabolites were employed as exposure factors, ESUS served as the outcome variable, and single nucleotide polymorphisms (SNPs) exhibiting significant association with ESUS were chosen as instrumental variables. The causal association between exposure factor metabolites and the outcome variable ESUS was assessed using two methods: MR-Egger regression and inverse variance-weighted (IVW) analysis.ResultsA causal relationship was observed between X-11593--O-methylascorbate* and ESUS, indicating a protective factor. Moreover, a causal relationship was identified between cholesterol esters in large very-low-density lipoprotein (VLDL), cholesterol esters in medium low-density lipoprotein (LDL), concentration of medium LDL particles, phospholipids in medium LDL, phenylalanine, total cholesterol in small LDL, total lipids in medium LDL and ESUS, representing risk factor. Funnel plots exhibited a symmetrical distribution of SNPs, while pleiotropic tests (p &gt; 0.05) and leave-one-out tests indicated that the results were relatively stable.ConclusionMetabolites are causally associated with ESUS. LDL and VLDL-related metabolites are identified as risk factors for ESUS.