bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insurance Status and Racial Disparities in Cancer-Specific Mortality in the United States: A Population-Based Analysis
Authors: Pan Hubert Y. , Walker Gary V. , Grant Stephen R. , Allen Pamela K. , Jiang Jing , Guadagnolo B. Ashleigh , Smith Benjamin D. , Koshy Matthew , Rusthoven Chad G. , Mahmood Usama 
Published: February 2017

Abstract
Background: Cancer-specific mortality (CSM) is known to be higher among blacks and lower among Hispanics compared with whites. Private insurance confers CSM benefit, but few studies have examined the relationship between insurance status and racial disparities. We sought to determine differences in CSM between races within insurance subgroups.
Methods: A population-based cohort of 577,716 patients age 18 to 64 years diagnosed with one of the 10 solid malignancies causing the greatest mortality over 2007 to 2012 were obtained from Surveillance, Epidemiology, and End Results. A Cox proportional hazards model for CSM was constructed to adjust for known prognostic factors, and interaction analysis between race and insurance was performed to generate stratum-specific HRs.
Results: Blacks had similar CSM to whites among the uninsured [HR = 1.01; 95% confidence interval (CI), 0.96–1.05], but higher CSM among the Medicaid (HR = 1.04; 95% CI, 0.01–1.07) and non-Medicaid (HR = 1.14; 95% CI, 1.12–1.16) strata. Hispanics had lower CSM compared with whites among uninsured (HR = 0.80; 95% CI, 0.76–0.85) and Medicaid (HR = 0.88; 95% CI, 0.85–0.91) patients, but there was no difference among non-Medicaid patients (HR = 0.99; 95% CI, 0.97–1.01). Asians had lower CSM compared with whites among all insurance types: uninsured (HR = 0.80; 95% CI, 0.76–0.85), Medicaid (HR = 0.81; 95% CI, 0.77–0.85), and non-Medicaid (HR = 0.85; 95% CI, 0.83–0.87).
Conclusions: The disparity between blacks and whites was largest, and the advantage of Hispanic race was absent within the non-Medicaid subgroup.
Impact: These findings suggest that whites derive greater benefit from private insurance than blacks and Hispanics. Further research is necessary to determine why this differential exists and how disparities can be improved. Cancer Epidemiol Biomarkers Prev; 26(6); 869–75. ©2017 AACR.
Dichotomous ALK-IHC Is a Better Predictor for ALK Inhibition Outcome than Traditional ALK-FISH in Advanced Non–Small Cell Lung Cancer
Authors: van der Wekken A.J. , Pelgrim R. , 't Hart N. , Werner N. , Mastik M.F. , Hendriks L. , van der Heijden E.H.F.M. , Looijen-Salamon M. , de Langen A.J. , Staal-van den Brekel J. , Riemersma S. , van den Borne B.E. , Speel E.J.M. , Dingemans A-M.C. , Hiltermann T.J.N. , van den Berg A. , Timens W. , Schuuring E. , Groen H.J.M. 
Published: February 2017

Abstract
Purpose: ALK rearrangement detection using FISH is the standard test to identify patients with non–small cell lung carcinoma (NSCLC) eligible for treatment with ALK inhibitors. Recently, ALK protein expression in resectable NSCLC showed predictive value. We evaluated tumor response rate and survival after crizotinib treatment of patients with advanced NSCLC with ALK activation using both dichotomous immunohistochemical (IHC) staining and FISH.
Experimental Design: Patients with stage IV NSCLC treated with crizotinib were selected. Tumor response was assessed. ALK rearrangements were detected by FISH (Vysis ALK-break-apart FISH-Probe KIT) and IHC [Ventana ALK (D5F3) CDx assay]. Cohorts of patients with ALK-FISH–positive advanced NSCLC from four other hospitals were used for validation.
Results: Twenty-nine consecutive patients with ALK-positive advanced NSCLC diagnosed by FISH and/or IHC on small biopsies or fine-needle aspirations (FNA) were treated with ALK inhibitors. All ALK-IHC–positive patients responded to crizotinib except three with primary resistance. No tumor response was observed in 13 ALK-FISH–positive but ALK-IHC–negative patients. This was confirmed in an external cohort of 16 patients. Receiver operator characteristic (ROC) curves for ALK-IHC and ALK-FISH compared with treatment outcome showed that dichotomous ALK-IHC outperforms ALK-FISH [tumor response area under the curve: (AUC), 0.86 vs. 0.64, P = 0.03; progression-free survival (PFS): AUC 0.86 vs. 0.36, P = 0.005; overall survival (OS): AUC, 0.78 vs. 0.41, P = 0.01, respectively].
Conclusions: Dichotomous ALK-IHC is superior to ALK-FISH on small biopsies and FNA to predict tumor response and survival to crizotinib for patients with advanced NSCLC. Our data strongly suggest adapting the guidelines and using dichotomous ALK-IHC as standard companion diagnostic test to select patients with NSCLC who benefit from ALK-targeting therapy. Clin Cancer Res; 23(15); 4251–8. ©2017 AACR.
Dual PI3K/mTOR Inhibition in Colorectal Cancers withAPCandPIK3CAMutations
Authors: Foley Tyler M. , Payne Susan N. , Pasch Cheri A. , Yueh Alex E. , Van De Hey Dana R. , Korkos Demetra P. , Clipson Linda , Maher Molly E. , Matkowskyj Kristina A. , Newton Michael A. , Deming Dustin A. 
Published: February 2017

AbstractTherapeutic targeting of the PI3K pathway is an active area of research in multiple cancer types, including breast and endometrial cancers. This pathway is commonly altered in cancer and plays an integral role in numerous vital cellular functions. Mutations in the PIK3CA gene, resulting in a constitutively active form of PI3K, often occur in colorectal cancer, though the population of patients who would benefit from targeting this pathway has yet to be identified. In human colorectal cancers, PIK3CA mutations most commonly occur concomitantly with loss of adenomatous polyposis coli (APC). Here, treatment strategies are investigated that target the PI3K pathway in colon cancers with mutations in APC and PIK3CA. Colorectal cancer spheroids with Apc and Pik3ca mutations were generated and characterized confirming that these cultures represent the tumors from which they were derived. Pan and alpha isomer–specific PI3K inhibitors did not induce a significant treatment response, whereas the dual PI3K/mTOR inhibitors BEZ235 and LY3023414 induced a dramatic treatment response through decreased cellular proliferation and increased differentiation. The significant treatment responses were confirmed in mice with Apc and Pik3ca-mutant colon cancers as measured using endoscopy with a reduction in median lumen occlusion of 53% with BEZ235 and a 24% reduction with LY3023414 compared with an increase of 53% in controls (P &lt; 0.001 and P = 0.03, respectively). This response was also confirmed with 18F-FDG microPET/CT imaging.Implications: Spheroid models and transgenic mice suggest that dual PI3K/mTOR inhibition is a potential treatment strategy for APC and PIK3CA-mutant colorectal cancers. Thus, further clinical studies of dual PI3K/mTOR inhibitors are warranted in colorectal cancers with these mutations. Mol Cancer Res; 15(3); 317–27. ©2016 AACR.
ПСИХІЧНІ І ПСИХОТИЧНІ РОЗЛАДИ ТА ЕФЕКТИВНІСТЬ ВААРТ У ВІЛ-ІНФІКОВАНИХ СПОЖИВАЧІВ ІН’ЄКЦІЙНИХ НАРКОТИКІВ
Authors: Zhyvytsia D. H. , Kazeka V. H. 
Published: February 2017

У ВІЛ-інфікованих споживачів ін’єкційних наркотиків (СІН) часто (35-50 %) діагностуються супутні психічні розлади. Замісна підтримувальна терапія (ЗПТ) метадоном і бупренорфіном є потужним елементом профілактики ВІЛ, а високоактивна антиретровірусна терапія (ВААРТ) – обов’язковою складовою комплексної медичної допомоги ВІЛ-інфікованим. Мета дослідження – оцінка впливу психічних та психотичних розладів на ефективність ВААРТ у хворих на ВІЛ-інфекцію СІН при проведенні ЗПТ. У дослідження включено 33 хворих на ВІЛ-інфекцію СІН, в яких до початку ЗПТ, ВААРТ і через 24 тиж. лікування проводилася оцінка ступеня психічних й психотичних розладів за шкалами BPRS і MADRS. Вірусологічна ефективність ВААРТ визначалася на 24-му тиж. лікування.
ВПЛИВ ТОКСИЧНОГО УРАЖЕННЯ ПЕЧІНКИ НА ЕФЕКТИВНІСТЬ ЛІКУВАННЯ ХІМІОРЕЗИСТЕНТНОГО ТУБЕРКУЛЬОЗУ ЛЕГЕНЬ
Authors: Okusok O. M. , Hryshchuk L. A. 
Published: February 2017

Своєчасна діагностика побічних ефектів, спричинених протитуберкульозними препаратами, зокрема токсичного ураження печінки, має важливе значення при лікуванні хворих на хіміорезистентний туберкульоз (ТБ) легень. Досліджено лікування 62 хворих на вперше діагностований хіміорезистентний ТБ легень. Проаналізовано залежність ефективності лікування таких хворих від наявності токсичного ураження печінки під час терапії в стаціонарних умовах. Встановлено, що максимальна кількість токсичних ускладнень з боку печінки спостерігається переважно на 2-5-му місяці терапії. У групі пацієнтів без токсичного ураження печінки під час лікування показники ефективності терапії були кращі, ніж у групі з таким ускладненням. Бактеріовиділення припинилось у 67,5 проти 54,8 %, порожнини розпаду закрились відповідно у 36,4 проти 27,8 % осіб. Для покращення ефективності лікування хворих на хіміорезистентний ТБ легень слід розширити спектр біохімічних обстежень крові з метою ранньої діагностики функціональних порушень печінки. При підозрі на токсичне ураження печінки треба своє­часно призначати ефективні гепатопротекторні препарати.
Експериментальна оцінка процесів регенерації кісткової тканини шляхом аналізу ферментативної активності кислої та лужної фосфатаз
Authors: Skochylo O. V. 
Published: February 2017

We explored the dynamics of changes activity indexes of acid and alkaline phosphatases on the models of created bone defect and compared the results with the data obtained after leading bone defects plastic with the material based on hydroxyapatite and polilaktide with different percentage of components (the first and the Second research groups). We established that the demineralization process lasts up to 7th days in all groups. At a control already on 14th day it starts to dominate the reverse processes that reach their maximum at 30th day, followed by a balance of both these antagonistic processes. In the first experimental group mineralization processes are sharply intensive in between 14th and 30ty day, and keeping a positive balance even at the 90th and 180th day. In the second experimental group the processes of mineralization is implementing till the 21st day with the highest efficiency. Then, at the 30th day mineralization intensity decreases rapidly and almost completely normalizes on the 180th day.
Зміни вмісту метаболітів азоту та ендотеліну-1 в ротовій рідині хворих на генералізований пародонтит на тлі цукрового діабету 1 типу з кардіоміопатією
Authors: Shkrebnyuk R. Yu. , Bandrivskyі Yu. L. 
Published: February 2017

The work adduces the parameters of endothelial dysfunction according to indices (NO2+NO3) and endothelin-1 (ET–1) in оral serum in patients with generalized parodontitis on the backdround of diabetes mellitus type 1 with cardiomiopathy (main group) and in persons with GP without general somatic diseases (comparative group). When comparative evaluation of frequency of change of ET-1, NO2+NO3 it was established that patients with GP on the background of diabetes mellitus type 1 with cardiomiopathy differs from patients with GP without general somatic diseases more significant changes of metabolites of nitrogen and endothelin-1, where when intensifying of processes in examined patients’ parodontium the meaning of analyzed indices characterized more pronocenced disbalance.
Особливості перебігу карієсу зубів у дітей із захворюваннями шлунково-кишкового тракту
Authors: Luchynskyi M. A. , Rozhko V. I. 
Published: February 2017

The chronic diseases of the gastrointestinal tract and frequent exasperation may lead to decreased metabolism and immunologic reactivity that assists to development of tooth decay. The research aim was to study the indexes of prevalence and intensity of tooth decay for children with the diseases of gastrointestinal tract. For the decision of the goаl of the work were inspected 357 children 6‒15 years–old. As a result of undertaken studies there was found that high prevalence (84.31±1.93.%) and intensity (8.96±0.15 tooth) of caries was determined in children with the gastrointestinal tract diseases, with the expressed tendency to complications, with predominating of the subcompensated and decompensated forms of caries that made progress with the increase of age of this group of patients.
Використання ортодонтичної брекет-системи як додаткового методу фіксації за умов функціонально-стабільного остеосинтезу в фронтальній ділянці нижньої щелепи: власний досвід
Authors: Vares Ya. E. , Chehrynets N. V. , Medvid Yu. O. 
Published: February 2017

In this scientific research on the basis of literary review and own clinical experience the results of treatment of 15 patients with symphyseal/parasymphyseal fractures in 12 patients were combined with fractures of other sites (angle, condylar process) by means of functionally stable osteosynthesis with additional mono- or intermaxillary fixation with elements of non-removable orthodontic technique (brackets Victory®(3М Unitek®, USA)), which were fixed on teeth according to standart method, are generalized. In all 15 cases anatomical and functional results of symphyseal/parasymphyseal osteosynthesis with additional bracket fixation were evaluated by us as good. A normalization of mandibular anatomical shape and bite was confirmed both clinically and roentgenologically. The terms of temporary intermaxillary fixation were from 1 to 8 days depending on amount and locations of fractures. There were no inflammatory complications or non-union. It was established that employment of bracket system, oppositely to traditional splinting techniques, provides teeth stabilization in fracture gap as well as interfragmentary compression due to directed elastic pull, which allow to widen the indications for leaving teeth in situ, especially in aestetically important areas.
Діагностичний алгоритм у хворих із гострим калькульозним холециститом та підозрою на холедохолітіаз
Authors: Savoliuk S. I. , Svyrydiuk B. V. 
Published: February 2017

Проведено аналіз інструментальної діагностики 316 хворих на гострий калькульозний холецистит із підозрою на холедохолітіаз. У даній групі хворих чоловіків було 105 (33,2 %), жінок – 211 (66,8 %). Вік хворих – від 42 до 84 років. Всі пацієнти були обстежені відповідно до протоколів та стандартів надання медичної допомоги клініко-лабораторно, інструментально. У день госпіталізації хворим виконано УЗД ОЧП з подальшим УЗ-контролем наступного дня після відповідної підготовки. Під час УЗД ОЧП діагностовано 97 випадків холедохолітіазу, що дозволило відразу планувати операційне втручання. Всіх інших хворих поділено на дві групи. У першій групі (115 хворих) для подальшої діагностики виконували ЕРПХГ, в другій групі (104 хворих) – МР ПХГ. За результатами досліджень, встановлено, що МР ПХГ має чутливість у діагностиці холедохолітіазу 99 %, а ЕРПХГ – 97,1 %. Важливо відмітити, що виконання ЕРПХГ може супроводжуватись такими ускладненнями, як алергічні реакції, гострий холангіт та гострий холецистит, які ми спостерігали у 5 випадках (4,3 %). При виконанні МР ПХГ ускладнень не відзначили. Іншою перевагою МР ПХГ є забезпечення 3D-візуалізації протокової системи, що полегшує оперування, сприяє зменшенню часу операції та кількості операційних ускладнень, у тому числі ятрогенних.
Відкриті і закриті методи декомпресії тонкої кишки у хворих на гостру непрохідність травного каналу
Authors: Benedykt V. V. 
Published: February 2017

Порушення функції травного каналу у хворих на гостру непрохідність кишки є однією з головних причин розвитку поліорганної недостатності і несприятливих наслідків. Використання декомпресії тонкої кишки має вирішальне значення під час лікування цього захворювання. Метою є визначення ефективності різних методів декомпресії тонкої кишки у хворих на непрохідність і визначення показань до різних методів їх використання. Проведено дослідження 122 хворих на гостру непрохідність кишки і 30 медичних карт стаціонарного хворого померлих пацієнтів. У 67,21 % випадків використано назогастроінтестинальну інтубацію, у 6,56 % пацієнтів – одномоментну декомпресію тонкої кишки під час операції. У 5-ти випадках при виконанні релапаротомії встановлено неефективність закритої антеградної декомпресії. Запропоновано спосіб ентеростомії для використання відкритої інтубації тонкої кишки. Визначено показання до використання відкритих методів декомпресії тонкої кишки у хворих на гостру непрохідність кишки.
Between War Machine and the Object Bricoleur
Authors: Firmo Adrienne De Oliveria 
Published: February 2017

No artigo é problematizada a antinomia entre exposições de arte e as ocupações por jovens brasileiros de escolas e instituições culturais, ocorridas em 2015 e 2016. A argumentação fundamenta-se nas definições de máquina de guerra e aparelho de Estado, de Gilles Deleuze e Félix Guarrari, e na conceituação de certa modalidade expositiva, entendida como proposicional ao alicerçar seus procedimentos metodológicos em técnicas artísticas como a colagem, o détounement e a bricolagem.
Mobilty in São Paulo: Concrete Faces of an Intangible Object
Authors: Gregori Marcia Sandoval 
Published: February 2017

Esse artigo tem como objetivo apresentar as representações da mobilidade em São Paulo a partir da história dos modos de deslocamento pela cidade e de suas imagens associadas. Para tanto serve‐se de documentos de época tais como filmes de ficção, músicas, documentários e anúncios publicitários. Pretende‐se apresentar a mobilidade enquanto objeto imaterial, sujeito a diferentes representações concretas e também imagéticas que expressam as relações sociais e produtivas numa metrópole ocupada com o trabalho, a produtividade e a eficiência. A mobilidade assume, dessa maneira, várias formas concretas e transforma‐se em diferentes objetos materiais, a expressar sua enorme importância social. Procura‐se ainda mostrar que a mobilidade, por seu caráter transversal e essencial para a reprodução do sistema hegemônico no espaço metropolitano, está sujeita a esquemas de dominação, segregação e preconceitos existentes na sociedade contemporânea num país em que a estrutura de classes ainda exibe sua face mais excludente e individualista.
Extending the concept of object: modernists dreams
Authors: Lourenço Maria Cecília França 
Published: February 2017

Comparações entre mudanças operadas na arte do país, entre os Anos 1920 e as décadas seguintes revelam como transmutaram‐se conceitos sobre qual a especificidade do objeto moderno; quais as instituições a serem implantadas; quais as táticas e as finalidades; qual o público alvo na recepção? Comenorme esforço aqueles moços com sonhos alteraram a realidade tanto do artista quanto do meio e a produção em direção oposta ao clichê, lugar‐comum e conservadorismo. Estes últimos vêm dominando o presente momento e então se inquere: ações inovadoras contribuiriam para alterar tal cenário sombrio?
Corrections of the original description of the genus Caiganga and description of the female of Caiganga antennata Carvalho &amp; Becker, 1957 (Heteroptera: Miridae: Phylinae)
Authors: FERREIRA PAULO SÉRGIO F. , SALLES FREDERICO F. , DIAS LUCIMAR G. , COELHO LÍVIA A. 
Published: February 2017

The authors examined the male holotype of Caiganga antennata Carvalho & Becker, 1957. It was verified that the descriptions of the monobasic genus and species were based on a teneral specimen. As a result, the generic morphological diagnosis is corrected. In addition, the previously unknown female of C. antennata is described and illustrated.
Enhanced Tropospheric Wave Forcing of Two Anticyclones in the Prephase of the January 2009 Major Stratospheric Sudden Warming Event
Authors: Schneidereit Andrea , Peters Dieter H. W. , Grams Christian M. , Quinting Julian F. , Keller Julia H. , Wolf Gabriel , Teubler Franziska , Riemer Michael , Martius Olivia 
Published: February 2017

Abstract
Tropospheric forcing of planetary wavenumber 2 is examined in the prephase of the major stratospheric sudden warming event in January 2009 (MSSW 2009). Because of a huge increase in Eliassen–Palm fluxes induced mainly by wavenumber 2, easterly angular momentum is transported into the Arctic stratosphere, deposited, and then decelerates the polar night jet. In agreement with earlier studies, the results reveal that the strongest eddy heat fluxes, associated with wavenumber 2, occur at 100 hPa during the prephase of MSSW 2009 in ERA-Interim. In addition, moderate conditions of the cold phase of ENSO (La Niña) contribute to the eddy heat flux anomaly. It is shown that enhanced tropospheric wave forcing over Alaska and Scandinavia is caused by tropical processes in two ways. First, in a climatological sense, La Niña contributes to an enhanced anticyclonic flow over both regions. Second, the Madden–Julian oscillation (MJO) has an indirect influence on the Alaskan ridge by enhancing eddy activity over the North Pacific. This is manifested in an increase in cyclone frequency and associated warm conveyor belt outflow, which contribute to the maintenance and amplification of the Alaskan anticyclone. The Scandinavian ridge is maintained by wave trains emanating from the Alaskan ridge propagating eastward, including an enhanced transport of eddy kinetic energy. The MSSW 2009 is an extraordinary case of how a beneficial phasing of La Niña and MJO conditions together with multiscale interactions enhances tropospheric forcing for wavenumber 2–induced zonal mean eddy heat flux in the lower stratosphere.
The relationship between sensory-processing patterns and occupational engagement among older persons
Authors: Engel-Yeger Batya , Rosenblum Sara 
Published: February 2017

Background. Meaningful occupational engagement is essential for successful aging. Sensory-processing abilities that are known to deteriorate with age may reduce occupational engagement. However, the relationship between sensory-processing abilities and occupational engagement among older persons in daily life is unknown. Purpose. This study examined the relationship between sensory-processing patterns and occupational engagement among older persons. Method. Participants were 180 people, ages 50 to 73 years, in good health, who lived in their homes. All participants completed the Adolescent/Adult Sensory Profile and the Activity Card Sort. Findings. Better registration of sensory input and greater sensory seeking were related to greater occupational engagement. Implications. Sensory-processing abilities among older persons and their relation to occupational engagement in various life settings should receive attention in research and practice. Occupational therapists should encourage older people to seek sensory input and provide them with rich sensory environments for enhancing meaningful engagement in real life.