bluuebunny/crossref_metadata_2025_split huggingface dataset:
Stem Cell–Mediated Paracrine Signaling Alters Fibroplasia in Human Vocal Fold Fibroblasts in Vitro
Authors: Hiwatashi Nao , Bing Renjie , Kraja Iv , Branski Ryan C. 
Published: June 2017

Objectives: Interactions between mesenchymal stem cells (MSCs) and native vocal fold fibroblasts (VFFs) have not been described in spite of promising preliminary data regarding the effects of MSCs on vocal fold repair in vivo. The current study employed a conditioned media (CM) model to investigate the paracrine effects of bone marrow–derived mesenchymal stem cells (BMSCs) on VFFs. Methods: Human VFFs were treated with transforming growth factor-β1 (TGF-β1; 10 ng/mL), CM from human BMSCs following 48 hours of TGF-β1 stimulation, or CM+TGF-β1. Proliferation, immunocytochemistry for alpha smooth muscle actin (αSMA), migration, and collagen gel contraction were quantified as well as transcription of components of the TGF-β signaling pathway. Results: Transforming growth factor-β1 accelerated proliferation and induced αSMA in VFFs; these effects were suppressed with CM ( P = .009, P < .001, respectively). The CM+TGF-β1 condition increased cell migration ( P = .02) and decreased gel contraction; CM+TGF-β1 also inhibited TGF-β signaling via significant upregulation of NR4A1 as well as downregulation of S MAD3 and TGF-β1 relative to TGF-β1 stimulation in the absence of CM ( P = .002, P < .001, and P = .005, respectively). Conclusions: Conditioned media affected many profibrotic cell activities in TGF-β1–stimulated VFFs, likely related to altered TGF-β signaling. These data provide preliminary insight regarding the antifibrotic effects of MSCs and further support their progression to clinical utility.
Searching for Affective and Cognitive Restoration: Examining the Restorative Effects of Casual Video Game Play
Authors: Rupp Michael A. , Sweetman Richard , Sosa Alejandra E. , Smither Janan A. , McConnell Daniel S. 
Published: June 2017

Objective: We investigated the effects of a passive break, relaxation activity, and casual video game on affect, stress, engagement, and cognitive performance. Background: Reducing stress and improving cognitive performance is critical across many domains. Previous studies investigated taking a break, relaxation techniques, or playing a game; however, these methods have not been compared within a single experiment. Method: Participants completed a baseline affective and cognitive assessment (ACA), which included the Positive and Negative Affect Schedule, shortened version of the Dundee Stress State Questionnaire, and backward digit-span. Next, participants completed a vigilance task, followed by another ACA. Participants were then assigned at random to complete a break or relaxation activity or play a casual video game, followed by a final ACA. Results: Participants who played the casual video game exhibited greater engagement and affective restoration than the relaxation condition. The break condition slightly decreased affect and prevented cognitive restoration. Conclusion: Playing a casual video game even briefly can restore individuals’ affective abilities, making it a suitable activity to restore mood in response to stress. However, future research is needed to find activities capable of cognitive restoration. Application: Many activities in life require sustained cognitive demand, which are stressful and decrease performance, especially for workers in performance-critical domains. Our research suggests some leisure activities are better than others for restoring fatigued affective processes.
Professional and non-professional raters’ responsiveness to fluency and accuracy in L2 speech: An experimental approach
Authors: Duijm Klaartje , Schoonen Rob , Hulstijn Jan H. 
Published: June 2017

It is general practice to use rater judgments in speaking proficiency testing. However, it has been shown that raters’ knowledge and experience may influence their ratings, both in terms of leniency and varied focus on different aspects of speech. The purpose of this study is to identify raters’ relative responsiveness to fluency and linguistic accuracy in an occupational context, and to investigate whether professional and non-professional raters with a broad exposure to L2 speech demonstrate similar responsiveness to these two aspects. To this end, an experimental approach was applied. Fluency and accuracy were separated and systematically manipulated. As it is known that foreign accentedness of speech influences raters’ judgments, this factor was accounted for. Seventeen responses to a Dutch L2 exam in a vocational context were converted into four different versions manipulated for morpho-syntactical accuracy and/or fluency, and read by a Dutch L2 actor, resulting in 68 stimuli. Fifty-five professional raters and 41 non-trained, potential stakeholders holistically rated all stimuli. All raters had extensive prior exposure to spoken L2 Dutch. Linear mixed modeling showed that improvement of either fluency or accuracy led to significantly higher ratings by both linguistically trained and non-trained raters. This finding confirms that both groups perceive these aspects to be important features of speaking proficiency. Raters seemed to be more responsive to improvement of accuracy than of fluency. The linguistically non-trained raters seemed to appreciate the fluency improvement more than linguistically trained raters. The linguistically trained raters rewarded morpho-syntactical improvement relatively higher than the non-trained raters. This latter effect was explained by the finding that the linguistically trained raters seemed to be more preoccupied with accuracy, according to their responses to a questionnaire. This result suggests that raters with linguistic expertise were more attentive to accuracy whereas non-trained raters were relatively more attentive to fluency.
Disability and the impact of need for periodontal care on quality of life: A cross-sectional study
Authors: El Tantawi Maha , AlAgl Adel 
Published: June 2017

Objective The need for periodontal care may negatively impact daily life. We compared the need for periodontal care and its impact on daily life between disabled and healthy adults in the Eastern Province, Saudi Arabia. Methods In this cross-sectional study of 819 adults, a questionnaire was used to assess personal background factors; the impact of periodontitis on pain, avoiding foods, embarrassment, sleeplessness, work absence, and discontinuing daily activities; and risk factors (smoking, diabetes, toothbrushing, insurance, professional tooth cleaning, and dental visits). The outcome was clinically assessed need for periodontal care impacting daily life. The relationship between the outcome and risk factors adjusted for personal background and disability was assessed using ordinal regression. Results Healthy and disabled persons had a high need for periodontal care (66.8%). Current smokers had a higher likelihood and health-insured persons had a lower likelihood of need for periodontal care impacting daily life regardless of whether disability was considered. Conclusions Most adults needed periodontal care, and disabled persons experienced a greater impact on life. Current smokers and uninsured persons were more likely to need periodontal care impacting daily life. Our findings are important for the prevention of periodontitis through tobacco cessation and extending insurance coverage.
Effects of Time to Start Training After Acute Patellar Tendon Enthesis Injuries on Healing of the Injury in a Rabbit Model
Authors: Wang Lin , Xiong Kaiyu , Wang Bo , Liang Xiaotian , Li Haiwei , Liu Haitao , He Hui 
Published: June 2017

Background: A patellar tendon injury is a common injury in sports. The optimal time to start training after an acute, proximal patellar enthesis injury is still unclear. Hypothesis: The time to start training after an acute, proximal patellar enthesis injury significantly affects healing of the patellar tendon 4 weeks after the injury. Study Design: Controlled laboratory study. Methods: The left hindlimbs of 35 mature female rabbits were randomly assigned to 5 injury groups including a 4-week natural healing group (NH4W) and 4 training groups that started low-intensity training at 24 hours (POST24), 48 hours (POST48), 72 hours (POST72), and 96 hours (POST96) after an acute patellar tendon injury, with 7 limbs in each group. The right hindlimbs of the NH4W group were used as a control group (CON). An acute, proximal patellar enthesis injury was created in all injury groups. The training groups underwent low-intensity quadriceps training for 2 hours per day and 3 days per week for 4 weeks. Histological and radiographic data were collected and analyzed. Results: The cell densities of the training groups were significantly lower than those of the NH4W and CON groups ( P = .01). The fibrocartilage zone was significantly thicker in the POST24, POST48, and POST72 groups compared with the CON and NH4W groups and was the thickest in the POST24 group ( P = .01). The bone surface to bone volume ratio was significantly higher in all the injury groups compared with the CON group and in the POST24 group compared with the other groups ( P = .01). Trabecular thickness was significantly lower in all the injury groups compared with the CON group and in the POST24 group compared with the other groups ( P = .01). Conclusion: Resting without training in the first 96 hours after an acute patellar tendon enthesis injury resulted in the best recovery of cell density in the tendon enthesis 4 weeks after the injury. Starting training 96 hours after the injury resulted in the best recovery of fibrocartilage zone thickness. Starting training 48 to 96 hours after the injury resulted in the best healing of the bone component of the attachment site 4 weeks after the injury. The optimal time to start training may be longer than 96 hours after an acute patellar tendon enthesis injury for the best overall healing of the tendon enthesis 4 weeks after the injury. Clinical Relevance: A rest of a minimal 72 hours may be needed for the best healing of a patellar tendon enthesis after an acute injury. Future studies are needed to determine the optimal time to start training after an acute patellar tendon injury.
Autograft Versus Allograft for Posterior Cruciate Ligament Reconstruction: An Updated Systematic Review and Meta-analysis
Authors: Belk John W. , Kraeutler Matthew J. , Purcell Justin M. , McCarty Eric C. 
Published: June 2017

Background: Multiple studies have demonstrated a higher risk of graft failure after anterior cruciate ligament reconstruction with allograft, but limited data are available comparing outcomes of posterior cruciate ligament reconstruction (PCLR) with autograft versus allograft. Purpose: To compare the clinical outcomes of autograft versus allograft for primary PCLR. Study Design: Systematic review. Methods: A systematic review was performed by searching PubMed, the Cochrane Library, and EMBASE to locate studies (level of evidence I-III) comparing clinical outcomes of autograft versus allograft in patients undergoing primary PCLR with the conventional transtibial technique. Search terms used were “posterior cruciate ligament,” “autograft,” and “allograft.” Patients were evaluated based on graft failure rate, examination of knee laxity, and patient-reported outcome scores (Lysholm, Tegner, subjective International Knee Documentation Committee [IKDC], and objective IKDC scores). Results: Five studies (2 level II, 3 level III) were identified that met inclusion criteria, including a total of 132 patients undergoing PCLR with autograft (semitendinosus-gracilis or bone–patellar tendon–bone) and 110 patients with allograft (tibialis anterior, Achilles tendon, or bone–patellar tendon–bone). No patients experienced graft failure. Average anteroposterior (AP) knee laxity was significantly higher in allograft patients (3.8 mm) compared with autograft patients (3.1 mm) ( P < .01). Subjective IKDC, Lysholm, and Tegner scores improved for both groups across studies, without a significant difference in improvement between groups except in one study, in which Lysholm scores improved to a significantly greater extent in the autograft group ( P < .01). Conclusion: Patients undergoing primary PCLR with either autograft or allograft can be expected to experience improvement in clinical outcomes. Autograft patients experienced less AP knee laxity postoperatively, although the clinical significance of this is unclear and subjective outcomes improved substantially and to a similar degree in both groups.
A Pain Education Intervention for Patients Undergoing Ambulatory Inguinal Hernia Repair
Authors: Sawhney Monakshi , Watt-Watson Judy , McGillion Michael 
Published: June 2017

BackgroundInguinal hernia repair is a common ambulatory surgery after which many patients experience moderate to severe post-operative pain. Limited research has examined the effect of education interventions to reduce pain after ambulatory surgery.PurposeThis trial evaluated the effectiveness of an individualized Hernia Repair Education Intervention (HREI) for patients following inguinal hernia repair.MethodPre-operatively, participants (N = 82) were randomized to either the intervention (HREI) or the usual care group. The HREI included written and verbal information regarding managing pain and two telephone support calls (before and after surgery). The primary outcome was WORST 24-h pain intensity on movement on post-operative day 2. Secondary outcomes included pain intensity at rest and movement, pain-related interference with activities, pain quality, analgesics consumed, and adverse effects at post-operative days 2 and 7.ResultsAt day 2, the intervention group reported significantly lower scores across pain intensity outcomes, including WORST 24-h pain on movement and at rest (p < 0.001), and pain NOW on movement and at rest (p = 0.001).ConclusionThese findings suggest that the HREI may improve patients’ pain and function following ambulatory inguinal hernia repair. Further research should examine the effectiveness of an education intervention over a longer period of time.
The Most Common Comorbidities in Dandy-Walker Syndrome Patients: A Systematic Review of Case Reports
Authors: Stambolliu Emelina , Ioakeim-Ioannidou Myrsini , Kontokostas Kimonas , Dakoutrou Maria , Kousoulis Antonis A. 
Published: June 2017

Objective: Dandy-Walker syndrome (DWS) is a rare neurologic multi-entity malformation. This review aimed at reporting its main nonneurologic comorbidities. Methods: Following PRISMA guidelines, search in Medline was conducted (2000-2014, keyword: dandy-walker). Age, sex, country, DWS type, consanguinity or siblings with DWS, and recorded coexistent conditions (by ICD10 category) were extracted for 187 patients (46.5% male, 43% from Asia) from 168 case reports. Results: Diagnosis was most often set in <1 year old (40.6%) or >12 years old (27.8%). One-third of cases had a chromosomal abnormality or syndrome (n = 8 PHACE), 27% had a cardiovascular condition (n = 7 Patent Ductus Arteriosus), 24% had a disease of eye and ear (n = 9 cataract); most common malignancy was nephroblastoma (n = 8, all Asian). Almost one-fifth had a mental illness diagnosis; only 6.4% had mild or severe intellectual disability. Conclusion: The spread of comorbidities calls for early diagnosis and multidisciplinary research and practice, especially as many cases remain clinically asymptomatic for years.
Effectiveness of intra-articular therapies in osteoarthritis: a literature review
Authors: Wehling Peter , Evans Christopher , Wehling Jana , Maixner William 
Published: June 2017

Osteoarthritis is a painful, chronic disease with widespread burden on patients, communities, health and social care systems. Conservative therapies, such as nonpharmacological interventions, systemic drug treatment and intra-articular therapies are used before resorting to surgery; nonetheless, disease control often remains inadequate. Recent advances in osteoarthritis management have aimed to provide greater variety of treatment options. Here, we summarize a targeted literature review evaluating efficacy and safety of intra-articular therapies for osteoarthritis. Injections of intra-articular therapies directly into the joint avoid conventional barriers to joint entry, increase bioavailability and lower systemic toxicity. Intra-articular corticosteroids and hyaluronic acid are established United States Food and Drug Administration (US FDA)/European Medicines Agency (EMA)-approved treatments; however, concerns exist regarding effect duration, safety, effectiveness across populations and heterogeneity. Newer therapies, such as autologous blood products and mesenchymal stem cells, are in development. Benefits of autologous blood products (e.g. platelet-rich plasma, autologous conditioned serum) include an expected improved safety profile and direct targeting of osteoarthritis-related pathophysiology. Autologous conditioned serum is cell-free and manufactured by a standardized process, whereas platelet-rich plasma composition and characteristics can vary. Currently, only limited efficacy comparisons between these biological treatments can be drawn; long-term clinical and safety studies are needed to increase the efficacy evidence base and earn consideration in treatment frameworks.
Comparison of the efficacy of intravenous tranexamic acid with and without topical administration versus placebo in urgent endoscopy rate for acute gastrointestinal bleeding: A double-blind randomized controlled trial
Authors: Tavakoli Nader , Mokhtare Marjan , Agah Shahram , Azizi Ali , Masoodi Mohsen , Amiri Hassan , Sheikhvatan Mehrdad , Syedsalehi Bahare , Behnam Behdad , Arabahmadi Mehran , Mehrazi Maryam 
Published: June 2017

Background Tranexamic acid (TXA), a synthetic antifibrinolytic drug, is effective as a treatment for serious hemorrhage, including bleeding arising from major trauma and post-operative interventions. Significant acute gastrointestinal bleeding may have a poor outcome despite routine medical and endoscopic treatments. The aim of this study was to assess whether early intravenous and/or intravenous plus topical administration of TXA reduces the need for urgent endoscopy for acute gastrointestinal bleeding. Method This double-blind randomized clinical trial included 410 patients with proven acute gastrointestinal bleeding. All patients received conventional therapy. The subjects were randomized to three groups: (A) 138 patients received intravenous TXA (1 g q6h); (B) 133 patients received topical TXA (1 g single dose by nasogastric tube) plus systemic TXA; and (C) 139 patients received a placebo (sodium chloride 0.9%) for 24 hours. Subgroup statistical analyses were conducted for urgent endoscopy, mortality, re-bleeding, blood transfusion, endoscopic and/or surgical intervention rates, and health status. Results The time to endoscopy was significantly shorter in group C (15.58 ± 7.994, p < 0.001). A need for urgent endoscopy was seen in 14.49%, 10.52%, and 30.21% of patients in groups A, B, and C, respectively ( p < 0.001). No significant statistical differences were seen between treatment groups regarding mortality, re-bleeding, blood transfusion, and endoscopic and/or surgical intervention rates. No thromboembolic event was documented during the 1-week follow up. Conclusions Our results showed that the antifibrinolytic properties of TXA can aid in changing an urgent endoscopy to an elective procedure, with better outcomes for both physicians and patients.
Analysis of Origins of Admission for Solid Tumor Oncology Inpatients: Disease Severity and Outcomes
Authors: Wee Christopher E. , Goodman Lindsey M. , Varella Leticia , Rybicki Lisa A. , Montero Alberto J. , Estfan Bassam N. , Best Carolyn H. , Stevenson James P. 
Published: June 2017

Purpose: Hospital transfers may affect clinical outcomes. Evaluation of admission by source of transfer, time of admission, and provider type may identify opportunities to improve inpatient outcomes. Methods: We reviewed charts of patients admitted to the solid tumor oncology service between July and December 2014 from the Cleveland Clinic Foundation (CCF) Main Campus emergency department (ED), CCF Regional EDs, outside hospital (OSH) ED, OSH inpatient services, and CCF outpatient clinics. Data collected included time of admission, mortality and severity risk scores, and provider type. Risk factors were assessed for clinical outcomes, including activations of the Adult Medical Emergency Team, intensive care unit transfers, in-hospital mortality, and length of stay (LOS). Results: Five hundred admissions were included. OSH inpatient transfers had significantly higher disease severity compared with all other origins of admission. OSH inpatient transfers demonstrated significantly longer LOS compared with all other origins of admission, and higher mortality rates compared with the outpatient direct admits and CCF Main Campus ED admits. After adjusting for disease severity and risk of mortality, OSH ED patients remained at higher risk for Adult Medical Emergency Team activation, OSH inpatient transfers had the longest LOS, and CCF Main Campus ED patients had the lowest risk of mortality. Time of admission and provider type were not associated with any of the outcomes. Conclusion: Oncology inpatients transferred from an outside health care facility are at higher risk for adverse outcomes. The magnitude of difference is lessened, but still significant, after adjustment for disease severity and risk of mortality.
Black women’s bodies and blackface in fashion magazines
Authors: Duan Noël Siqi 
Published: June 2017

Abstract
Race as an aesthetic has been a contentious issue in the modelling industry since the early days of organized aesthetic labour, as black models straddle a tightrope between following a bourgeois, white ideal ‘look’ or highlighting their ‘exotic’ non-white features in order to stand out. Models may be the faces of fashion, yet photographers, editors, agents, art directors and stylists are the gatekeepers making the aesthetic choices and decisions. There have been strides forward in the fashion industry – on the runway, in publications and on social media – to celebrate diverse forms of beauty, including those that fall outside of the de facto standard. These efforts tend to confuse race with aesthetics, that is, with stereotypical racial styling of non-white models, and blackface is still prevalent in the most prestigious of fashion magazines.
Removing personal constraints via Proxy scene enactment
Authors: Wiener Daniel J. 
Published: June 2017

Abstract
Proxy scenes, improvised enactments devised by drama therapists, are useful in overcoming client limitations (‘constraints’) as they explore, experiment with or practise change. This article presents four underlying variables that may be calibrated to create effective Proxy scenes, elucidates the underlying principle informing therapists’ practical choices, and illustrates Proxy scene application to the example of an individual client in group therapy.
Attachment performs: Framing attachment theory within the dramatic worldview
Authors: Versaci Rebecca 
Published: June 2017

Abstract
This article proposes that drama therapeutic intervention may be particularly effective in promoting secure attachment between children and their caregivers. The author frames attachment as a theatrical performance in which the child and the caregiver are cast as players in the dramatic action. The author then reviews three elements of drama therapeutic intervention and their relationship to attachment: aesthetic distance, role and interpersonal exchange. These elements should be considered as drama therapists develop protocols to serve young children and their caregivers.