bluuebunny/crossref_metadata_2025_split huggingface dataset:
TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling
Authors: Liu Lingying , Song Huifeng , Duan Hongjie , Chai Jiake , Yang Jing , Li Xiao , Yu Yonghui , Zhang Xulong , Hu Xiaohong , Xiao Mengjing , Feng Rui , Yin Huinan , Hu Quan , Yang Longlong , Du Jundong , Li Tianran 
Published: July 2016

AbstractThe hMSCs have become a promising approach for inflammation treatment in acute phase. Our previous study has demonstrated that human umbilical cord-MSCs could alleviate the inflammatory reaction of severely burned wound. In this study, we further investigated the potential role and mechanism of the MSCs on severe burn-induced excessive inflammation. Wistar rats were randomly divided into following groups: Sham, Burn, Burn+MSCs, Burn+MAPKs inhibitors and Burn, Burn+MSCs, Burn+Vehicle, Burn+siTSG-6, Burn+rhTSG-6 in the both experiments. It was found that MSCs could only down-regulate P38 and JNK signaling, but had no effect on ERK in peritoneal macrophages of severe burn rats. Furthermore, suppression of P38 and JNK activations significantly reduced the excessive inflammation induced by severe burn. TSG-6 was secreted by MSCs using different inflammatory mediators. TSG-6 from MSCs and recombinant human (rh)TSG-6 all significantly reduced activations of P38 and JNK signaling induced by severe burn and then attenuated excessive inflammations. On the contrary, knockdown TSG-6 in the cells significantly increased phosphorylation of P38 and JNK signaling and reduced therapeutic effect of the MSCs on excessive inflammation. Taken together, this study suggested TSG-6 from MSCs attenuated severe burn-induced excessive inflammation via inhibiting activation of P38 and JNK signaling.
Interaction of Sensitizing Dyes with Nanostructured TiO2 Film in Dye-Sensitized Solar Cells Using Terahertz Spectroscopy
Authors: Ghann William , Rahman Aunik , Rahman Anis , Uddin Jamal 
Published: July 2016

AbstractThe objective of this investigation was to shed light on the nature of interaction of different organic dyes and an inorganic dye, Ruthenium (II) polypyridine complex, with TiO2 nanoparticles. TiO2 is commonly deployed as an efficient energy transfer electrode in dye sensitized solar cells. The efficiency of dye sensitized solar cells is a function of the interaction of a dye with the electrode material such as TiO2. To the best of our knowledge the present study is the first effort in the determination of terahertz absorbance signals, investigation of real-time dye permeation kinetics and the surface profiling and 3D imaging of dye sensitized TiO2 films. Herein, we report that the terahertz spectra of the natural dye sensitized TiO2 films were distinctively different from that of the inorganic dye with prominent absorption of natural dyes occurring at approximately the same wavelength. It was observed that the permeation of the natural dyes were more uniform through the layers of the mesoporous TiO2 compared to the inorganic dye. Finally, defects and flaws on TiO2 film were easily recognized via surface profiling and 3D imaging of the films. The findings thus offer a new approach in characterization of dye sensitized solar cells.
Hepatocellular Carcinoma associated with Extra-hepatic Primary Malignancy: its Secular change, Clinical Manifestations and Survival
Authors: Kee Kwong Ming , Wang Jing-Houng , Wang Chih-Chi , Cheng Yu-Fan , Lu Sheng-Nan 
Published: July 2016

AbstractClinical manifestations between hepatocellular carcinoma (HCC) and extra-hepatic primary malignancy (EHPM) are lack of large-scale study. We enrolled 14555 HCC patients between 1986 and 2013 retrospectively. The EHPM was classified as prior, synchronous and metachronous group based on before, within and after 6 months of HCC diagnosis, respectively. The incidence rate of EHPM is 3.91% (95% confidence interval [CI]: 3.60–4.23%). Urogenital cancers, kidney and bladder, were at unexpected higher ranks. Older in age, Child-Pugh A cirrhosis, negativity of HBsAg and anti-HCV, and earlier BCLC staging are independent factors associated with EHPM. The survival rates of EHPM improve over time and also better than HCC-alone. Cox proportional-hazards regression shows independent poor prognostic factors are age >60, male, AFP levels ≥400 ng/ml, positivity of HBsAg, Child-Pugh B vs. A, Non-metachronous group, respectively, treated with local ablation, transcatheter arterial embolization, radiotherapy and supportive care vs. surgery, respectively, TNM stage IIIA vs. I, and BCLC stages A, B, C and D vs. 0, respectively. Survival of EHPM improve could be explained by early diagnosis and improve treatment of cancers.
Arabidopsis YL1/BPG2 Is Involved in Seedling Shoot Response to Salt Stress through ABI4
Authors: Li Peng-Cheng , Huang Jin-Guang , Yu Shao-Wei , Li Yuan-Yuan , Sun Peng , Wu Chang-Ai , Zheng Cheng-Chao 
Published: July 2016

AbstractThe chloroplast-localized proteins play roles in plant salt stress response, but their mechanisms remain largely unknown. In this study, we screened a yellow leaf mutant, yl1-1, whose shoots exhibited hypersensitivity to salt stress. We mapped YL1 to AT3G57180, which encodes a YqeH-type GTPase. YL1, as a chloroplast stroma-localized protein, could be markedly reduced by high salinity. Upon exposure to high salinity, seedling shoots of yl1-1 and yl1-2 accumulated significantly higher levels of Na+ than wild type. Expression analysis of factors involved in plant salt stress response showed that the expression of ABI4 was increased and HKT1 was evidently suppressed in mutant shoots compared with the wild type under normal growth conditions. Moreover, salinity effects on ABI4 and HKT1 were clearly weakened in the mutant shoots, suggesting that the loss of YL1 function impairs ABI4 and HKT1 expression. Notably, the shoots of yl1-2 abi4 double mutant exhibited stronger resistance to salt stress and accumulated less Na+ levels after salt treatment compared with the yl1-2 single mutant, suggesting the salt-sensitive phenotype of yl1-2 seedlings could be rescued via loss of ABI4 function. These results reveal that YL1 is involved in the salt stress response of seedling shoots through ABI4.
A novel allele of L-galactono-1,4-lactone dehydrogenase is associated with enhanced drought tolerance through affecting stomatal aperture in common wheat
Authors: Zhang Juncheng , Li Bin , Yang Yanping , Mu Peiyuan , Qian Weiqiang , Dong Lingli , Zhang Kunpu , Liu Xin , Qin Huanju , Ling Hongqing , Wang Daowen 
Published: July 2016

AbstractIn higher plants, L-galactono-1,4-lactone dehydrogenase (GLDH) plays important roles in ascorbic acid (AsA) biosynthesis and assembly of respiration complex I. Here we report three homoeologous genes (TaGLDH-A1, -B1and -D1) encoding common wheat GLDH isozymes and a unique allelic variant (TaGLDH-A1b) associated with enhanced drought tolerance.TaGLDH-A1, -B1and -D1were located on chromosomes 5A, 5B and 5D, respectively and their transcripts were found in multiple organs. The three homoeologs each conferred increased GLDH activity when ectopically expressed in tobacco. DecreasingTaGLDHexpression in wheat significantly reduced GLDH activity and AsA content.TaGLDH-A1bdiffered from wild type alleleTaGLDH-A1aby an in-frame deletion of three nucleotides. TaGLDH-A1b was biochemically less active than TaGLDH-A1a and the total GLDH activity levels were generally lower in the cultivars carryingTaGLDH-A1brelative to those withTaGLDH-A1a. Interestingly,TaGLDH-A1bcultivars showed stronger water deficiency tolerance thanTaGLDH-A1acultivars andTaGLDH-A1bco-segregated with decreased leaf water loss in a F2population. Finally,TaGLDH-A1bcultivars generally exhibited smaller leaf stomatal aperture thanTaGLDH-A1avarieties in control or water deficiency environments. Our work provides new information onGLDHgenes and function in higher plants.TaGLDH-A1bis likely useful for further studying and improving wheat tolerance to drought stress.
Order parameter analysis for low-dimensional behaviors of coupled phase-oscillators
Authors: Gao Jian , Xu Can , Sun Yuting , Zheng Zhigang 
Published: July 2016

AbstractCoupled phase-oscillators are important models related to synchronization. Recently, Ott-Antonsen(OA) ansatz is developed and used to get low-dimensional collective behaviors in coupled oscillator systems. In this paper, we develop a simple and concise approach based on equations of order parameters, namely, order parameter analysis, with which we point out that OA ansatz is rooted in the dynamical symmetry of order parameters. With our approach the scope of OA ansatz is identified as two conditions, i.e., the limit of infinitely many oscillators and only three nonzero Fourier coefficients of the coupling function. Coinciding with each of the conditions, a distinctive system out of the scope is taken into account and discussed with the order parameter analysis. Two approximation methods are introduced respectively, namely the expectation assumption and the dominating-term assumption.
Enhanced Lithium Storage in Reduced Graphene Oxide-supported M-phase Vanadium(IV) Dioxide Nanoparticles
Authors: Song Hee Jo , Choi Mingu , Kim Jae-Chan , Park Sangbaek , Lee Chan Woo , Hong Seong-Hyeon , Kim Byung-Kook , Kim Dong-Wan 
Published: July 2016

AbstractVanadium(IV) dioxide (VO2) has drawn attention as one of the most attractive electrode materials for lithium-ion batteries (LIBs), hence, much research has been conducted in various sectors in this field. However, to date, most of this research has focused on the VO2(B) polymorph, whereas electrochemical information on the use of VO2(M) in LIB electrodes is insufficient. Thus, it is worthwhile to explore the possibility of using VO2(M) for LIB electrode application, and to investigate whether its electrochemical properties can be improved. In this study, VO2(M) nanoparticles, incorporated with a reduced graphene oxide composite (NP-VO2/rGO), were successfully synthesized via a sol–gel assisted hydrothermal process by the chemical reduction of V2O5 gel, using hydrazine as the reducing agent. The particle size was less than 50 nm regardless of the presence of rGO. Also, NP-VO2/rGO exhibited a specific capacity of 283 mA h g−1 up to the 200th cycle at a current density of 60 mA g−1, indicating its potential to be used in LIBs.
Low temperature and high field regimes of connected kagome artificial spin ice: the role of domain wall topology
Authors: Zeissler Katharina , Chadha Megha , Lovell Edmund , Cohen Lesley F. , Branford Will R. 
Published: July 2016

AbstractArtificial spin ices are frustrated magnetic nanostructures where single domain nanobars act as macrosized spins. In connected kagome artificial spin ice arrays, reversal occurs along one-dimensional chains by propagation of ferromagnetic domain walls through Y-shaped vertices. Both the vertices and the walls are complex chiral objects with well-defined topological edge-charges. At room temperature, it is established that the topological edge-charges determine the exact switching reversal path taken. However, magnetic reversal at low temperatures has received much less attention and how these chiral objects interact at reduced temperature is unknown. In this study we use magnetic force microscopy to image the magnetic reversal process at low temperatures revealing the formation of quite remarkable high energy remanence states and a change in the dynamics of the reversal process. The implication is the breakdown of the artificial spin ice regime in these connected structures at low temperatures.
Correlative multiple porosimetries for reservoir sandstones with adoption of a new reference-sample-guided computed-tomographic method
Authors: Jin Jae Hwa , Kim Junho , Lee Jeong-Yil , Oh Young Min 
Published: July 2016

AbstractOne of the main interests in petroleum geology and reservoir engineering is to quantify the porosity of reservoir beds as accurately as possible. A variety of direct measurements, including methods of mercury intrusion, helium injection and petrographic image analysis, have been developed; however, their application frequently yields equivocal results because these methods are different in theoretical bases, means of measurement, and causes of measurement errors. Here, we present a set of porosities measured in Berea Sandstone samples by the multiple methods, in particular with adoption of a new method using computed tomography and reference samples. The multiple porosimetric data show a marked correlativeness among different methods, suggesting that these methods are compatible with each other. The new method of reference-sample-guided computed tomography is more effective than the previous methods when the accompanied merits such as experimental conveniences are taken into account.
Design of compact filtering rat‐race hybrid with λ/2‐resonators
Authors: Lu Yun‐Long , Wang Yi , Hua Changzhou , Liu Taijun 
Published: July 2016

A novel compact filtering rat‐race hybrid coupler with improved upper stopband is presented. Four coupled λ/2‐resonator pairs are utilised to replace the λ/4‐ and 3λ/4‐transmission lines in the conventional hybrid. Each coupled λ/2‐resonator pair exhibits a bandpass filtering response and acts as a K‐inverter. Eight resistors are placed at the centre of the λ/2‐resonators to suppress the second‐harmonic. For verification, a filtering rat‐race hybrid is implemented with a centre frequency of 1.27 GHz and 20 dB rejection band of 2.73 f0. Good in‐phase and out‐of‐phase characteristics are obtained. The proposed device has a simple circuit topology, compact size and good performance.
Research on multi‐attribute decision‐making in condition evaluation for power transformer using fuzzy AHP and modified weighted averaging combination
Authors: Sun Lingjie , Ma Zhao , Shang Yuwei , Liu Yingyi , Yuan Haiwen , Wu Guoliang 
Published: July 2016

Power transformers are of vital importance for the stable operation of power system. Hence, to grasp transformers’ health condition is of imminent importance. However, the evaluation of transformers’ health condition is bound with fuzzy, uncertainty, and even conflict information. To address these problems, a novel evaluation model for transformer, by integrating the merits of fuzzy set theory, fuzzy analytical hierarchical process (AHP), and modified weighted averaging combination, is proposed in this study. The evaluation model contains four factors: dissolved gas analysis, electrical testing, oil testing, and miscellaneous factors, as well as 20 indices. The evaluation process consists of three steps. First, the fuzzy set theory is used to obtain assessment grades for each quantified indices. Second, the fuzzy AHP using fuzzy preference programming, which extends classical AHP and can better tackle the uncertainty existed in the comparison matrix given by experts, is introduced to calculate the weights of indices. Finally, the assessment is processed through the modified weighted averaging combination, which is able to handle the conflicts among evidences. The proposed method is verified by evaluating a realistic transformer, and the results of field examples indicate that the method can evaluate the transformer health condition effectively.
Nanocrystalline mesoporous zeolite X with a considerable external surface area prepared via an ordered precursor: a potential adsorbent
Authors: Wang Xu , Yang Bin , Ma Jinghong , Fen Chunfeng , Li Ruifeng 
Published: July 2016

A nanocrystal zeolite X with intracrystalline mesopores has been successfully prepared by using organofunctionalised mesoporous silica in hydrothermal system. The as‐prepared zeolitic material persist the inherent framework structure of FAU zeolite, and present a crystallographic morphology of stacked three‐dimensional intergrowths made up of rectangular nanocrystals. The intracrystalline mesopores are formed via a bond‐blocking principle with hydrophobic carbon chains of organosilane inhibiting the growth of zeolite units and crystals in the channels of mesoporous silica during hydrothermal synthesis. The results showed that the zeolitic material has a considerable external surface area (247 m2 g−1)and mesopore volume (0.44 cm3 g−1), maintaining high Brunauer–Emmett–Teller surface area (991 m2 g−1) and large total pore volume (0.71 cm3 g−1), and clearly stating a larger adsorption capacity for p‐xylene at relative higher pressure.
Epigenetic regulation of
Kcna3
-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4
+
T-cell activation
Authors: Kang Jung-Ah , Park Sang-Heon , Jeong Sang Phil , Han Min-Hee , Lee Cho-Rong , Lee Kwang Min , Kim Namhee , Song Mi-Ryoung , Choi Murim , Ye Michael , Jung Guhung , Lee Won-Woo , Eom Soo Hyun , Park Chul-Seung , Park Sung-Gyoo 
Published: July 2016

Significance
In resting T cells, CRBN normally represses expression of the Kv1.3 potassium channel by regulating histone modifications to prevent hyperactivation of T cells. It does this by controlling recruitment of EZH1 to the potassium channel region of the Kcna3 gene (or locus). However, lack of CRBN causes up-regulation of Kv1.3 expression, which in turn increases potassium flux, thereby triggering increased calcium flux during T-cell activation.
Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease
Authors: Alexopoulou Zoi , Lang Johannes , Perrett Rebecca M. , Elschami Myriam , Hurry Madeleine E. D. , Kim Hyoung Tae , Mazaraki Dimitra , Szabo Aron , Kessler Benedikt M. , Goldberg Alfred Lewis , Ansorge Olaf , Fulga Tudor A. , Tofaris George K. 
Published: July 2016

Significance
A cardinal feature of Parkinson’s disease pathology is the aggregation of α-synuclein in ubiquitin-positive inclusions termed Lewy bodies, yet the composition of ubiquitin conjugates in these inclusions and their role in α-synuclein pathobiology remain unclear. Here we demonstrate that α-synuclein inclusions contain K63-linked ubiquitin chains, which are strikingly reduced in dopaminergic neurons. In these neurons, the deubiquitinase Usp8 is present in Lewy bodies, and its content is related inversely to the extent of K63-linked ubiquitination. Our mechanistic studies in vitro and in flies indicate that Usp8 interacts with and deconjugates K63-linked ubiquitin chains on α-synuclein, prolonging its half-life and increasing its toxicity. Thus, Usp8 appears to be a critical factor determining α-synuclein levels that could be targeted for therapies.
Current developments in the treatment of early-stage classical Hodgkin lymphoma
Authors: Borchmann Sven , von Tresckow Bastian , Engert Andreas 
Published: July 2016

Purpose of review
After presenting the current treatment recommendations for early-stage Hodgkin lymphoma, we give an overview on recently published clinical trials in this setting. Furthermore, the potential influence of current trials on the treatment of early-stage Hodgkin lymphoma and integration of newly emerging drugs into treatment protocols will be discussed.

Recent findings
Trials attempting treatment de-escalation and omission of radiotherapy on the basis of early interim PET-scans have been disappointing so far, but results of some large trials employing this strategy are still awaited. In contrast, a more defensive strategy of starting treatment with less aggressive doxorubicine, bleomycin, vinblastine, dacarbazine (ABVD) chemotherapy and intensifying treatment in early interim PET-positive patients has shown encouraging results. New drugs such as brentuximab vedotin and immune checkpoint inhibitors have shown promising results in relapsed and refractory Hodgkin lymphoma. Clinical trials of brentuximab vedotin in early-stage Hodgkin lymphoma have been initiated. Additionally, biomarker-based treatment de-escalation might be a possible route for future improvements.

Summary
The challenge for future clinical research in early-stage Hodgkin lymphoma is to continue to cure the majority of patients with first-line treatment while reducing long-term toxicity. New strategies to achieve that goal are currently being developed and will further refine treatment of early-stage Hodgkin lymphoma.
Evidence for functional and non-functional classes of peptides translated from long non-coding RNAs
Authors: Ruiz-Orera Jorge , Verdaguer-Grau Pol , Villanueva-Cañas José Luis , Messeguer Xavier , Albà M Mar 
Published: July 2016

AbstractThere is accumulating evidence that some genes have originatedde novofrom previously non-coding genomic sequences. However, the processes underlyingde novogene birth are still enigmatic. In particular, the appearance of a new functional protein seems highly improbable unless there is already a pool of neutrally evolving peptides that can at some point acquire new functions. Here we show for the first time that such peptides do not only exist but that they are prevalent among the translation products of mouse genes that lack homologues in rat and human. The data suggests that the translation of these peptides is due to the chance occurrence of open reading frames with a favorable codon composition. Our approach combines ribosome profiling experiments, proteomics data and non-synonymous and synonymous nucleotide polymorphism analysis. We propose that effectively neutral processes involving the expression of thousands of transcripts all the way down to proteins provide a basis forde novogene evolution.
Colocalization of GWAS and eQTL Signals Detects Target Genes
Authors: Hormozdiari Farhad , van de Bunt Martijn , Segrè Ayellet V. , Li Xiao , Joo Jong Wha J , Bilow Michael , Sul Jae Hoon , Sankararaman Sriram , Pasaniuc Bogdan , Eskin Eleazar 
Published: July 2016

AbstractThe vast majority of genome-wide association studies (GWAS) risk loci fall in non-coding regions of the genome. One possible hypothesis is that these GWAS risk loci alter the individual’s disease risk through their effect on gene expression in different tissues. In order to understand the mechanisms driving a GWAS risk locus, it is helpful to determine which gene is affected in specific tissue types. For example, the relevant gene and tissue may play a role in the disease mechanism if the same variant responsible for a GWAS locus also affects gene expression. Identifying whether or not the same variant is causal in both GWAS and eQTL studies is challenging due to the uncertainty induced by linkage disequilibrium (LD) and the fact that some loci harbor multiple causal variants. However, current methods that address this problem assume that each locus contains a single causal variant. In this paper, we present a new method, eCAVIAR, that is capable of accounting for LD while computing the quantity we refer to as the colocalization posterior probability (CLPP). The CLPP is the probability that the same variant is responsible for both the GWAS and eQTL signal. eCAVIAR has several key advantages. First, our method can account for more than one causal variant in any loci. Second, it can leverage summary statistics without accessing the individual genotype data. We use both simulated and real datasets to demonstrate the utility of our method. Utilizing publicly available eQTL data on 45 different tissues, we demonstrate that computing CLPP can prioritize likely relevant tissues and target genes for a set of Glucose and Insulin-related traits loci. eCAVIAR is available athttp://genetics.cs.ucla.edu/caviar/