bluuebunny/crossref_metadata_2025_split huggingface dataset:
The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice
Authors: Benito E , Ramachandran B , Schroeder H , Schmidt G , Urbanke H , Burkhardt S , Capece V , Dean C , Fischer A 
Published: September 2017

AbstractHistone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of Alzheimer’s disease. Thus, targeting histone acetylation is discussed as a novel approach to treat dementia. The histone acetylation landscape is shaped by chromatin writer and eraser proteins, while readers link chromatin state to cellular function. Chromatin readers emerged novel drug targets in cancer research but little is known about the manipulation of readers in the adult brain. Here we tested the effect of JQ1—a small-molecule inhibitor of the chromatin readers BRD2, BRD3, BRD4 and BRDT—on brain function and show that JQ1 is able to enhance cognitive performance and long-term potentiation in wild-type animals and in a mouse model for Alzheimer’s disease. Systemic administration of JQ1 elicited a hippocampal gene expression program that is associated with ion channel activity, transcription and DNA repair. Our findings suggest that JQ1 could be used as a therapy against dementia and should be further tested in the context of learning and memory.
Investigating the genetic underpinnings of early-life irritability
Authors: Riglin L , Eyre O , Cooper M , Collishaw S , Martin J , Langley K , Leibenluft E , Stringaris A , Thapar A K , Maughan B , O'Donovan M C , Thapar A 
Published: September 2017

AbstractSevere irritability is one of the commonest reasons prompting referral to mental health services. It is frequently seen in neurodevelopmental disorders that manifest early in development, especially attention-deficit/hyperactivity disorder (ADHD). However, irritability can also be conceptualized as a mood problem because of its links with anxiety/depressive disorders; notably DSM-5 currently classifies severe, childhood-onset irritability as a mood disorder. Investigations into the genetic nature of irritability are lacking although twin studies suggest it shares genetic risks with both ADHD and depression. We investigated the genetic underpinnings of irritability using a molecular genetic approach, testing the hypothesis that early irritability (in childhood/adolescence) is associated with genetic risk for ADHD, as indexed by polygenic risk scores (PRS). As a secondary aim we investigated associations between irritability and PRS for major depressive disorder (MDD). Three UK samples were utilized: two longitudinal population-based cohorts with irritability data from childhood (7 years) to adolescence (15–16 years), and one ADHD patient sample (6–18 years). Irritability was defined using parent reports. PRS were derived from large genome-wide association meta-analyses. We observed associations between ADHD PRS and early irritability in our clinical ADHD sample and one of the population samples. This suggests that early irritability traits share genetic risk with ADHD in the general population and are a marker of higher genetic loading in individuals with an ADHD diagnosis. Associations with MDD PRS were not observed. This suggests that early-onset irritability could be conceptualized as a neurodevelopmental difficulty, behaving more like disorders such as ADHD than mood disorders.
Polarisation‐independent UWB frequency selective surface based on 2.5D miniaturised hexagonal ring
Authors: Hua Boyu , He Xiaoxiang , Yang Yang 
Published: September 2017

A novel frequency selective surface (FSS) exploiting 2.5D miniaturised hexagonal rings (2.5D MHR) is proposed. It can obtain an ultra‐wide stopband and an improved polarisation‐independent property due to the compact hexagon arrangement of 2.5D MHRs. The −10 dB bandwidth of the proposed FSS is from 1.97 to 8.08 GHz, and the deviation of resonant frequencies at 30° under transverse electric/transverse magnetic polarisations is merely 0.006f0. A prototype of the proposed FSS is fabricated and measured to validate the good consistency between simulations and measurements.
Planetary Radio Interferometry and Doppler Experiment (PRIDE) technique: A test case of the Mars Express Phobos Flyby
Authors: Bocanegra-Bahamón T. M. , Molera Calvés G. , Gurvits L. I. , Duev D. A. , Pogrebenko S. V. , Cimò G. , Dirkx D. , Rosenblatt P. 
Published: September 2017

Context. Closed-loop Doppler data obtained by deep space tracking networks, such as the NASA Deep Space Network (DSN) and the ESA tracking station network (Estrack), are routinely used for navigation and science applications. By shadow tracking the spacecraft signal, Earth-based radio telescopes involved in the Planetary Radio Interferometry and Doppler Experiment (PRIDE) can provide open-loop Doppler tracking data only when the dedicated deep space tracking facilities are operating in closed-loop mode.
Aims. We explain the data processing pipeline in detail and discuss the capabilities of the technique and its potential applications in planetary science.
Methods. We provide the formulation of the observed and computed values of the Doppler data in PRIDE tracking of spacecraft and demonstrate the quality of the results using an experiment with the ESA Mars Express spacecraft as a test case.
Results. We find that the Doppler residuals and the corresponding noise budget of the open-loop Doppler detections obtained with the PRIDE stations compare to the closed-loop Doppler detections obtained with dedicated deep space tracking facilities.
Erstbehandlung von Patientinnen mit primärem Mammakarzinom: Evidenz, Kontroversen, Konsens
Authors: Untch Michael , Huober Jens , Jackisch Christian , Schneeweiss Andreas , Brucker Sara , Dall Peter , Denkert Carsten , Fasching Peter , Fehm Tanja , Gerber Bernd , Janni Wolfgang , Kühn Thorsten , Lüftner Diana , Möbus Volker , Müller Volkmar , Rody Achim , Sinn Peter , Thill Marc , Thomssen Christoph , Harbeck Nadia , Liedtke Cornelia 
Published: September 2017

ZusammenfassungSeit über 30 Jahren findet regelmäßig (in den letzten 6 Jahren alle 2 Jahre) die internationale St. Gallen-Konsensuskonferenz zur Behandlung von Patientinnen mit primärem Mammakarzinom statt. Die Ergebnisse des internationalen St. Gallen-Konsensus-Panels wurden auch dieses Jahr wieder von einer deutschen Arbeitsgruppe führender Brustkrebsexperten für den Klinikalltag in Deutschland diskutiert. Fünf der Brustkrebsexperten aus Deutschland sind zugleich Mitglieder des diesjährigen St. Gallen-Panels. Der Vergleich der St. Gallen-Empfehlungen mit den jährlich aktualisierten Therapieempfehlungen der Arbeitsgemeinschaft Gynäkologische Onkologie (AGO-Mamma 2017) und der aktuell im Jahre 2017 abgestimmten S3-Leitlinie ist sinnvoll. Die Empfehlungen des St. Gallen-Panels stellen ein Meinungsbild von Experten unterschiedlicher Länder und Fachdisziplinen dar, wohingegen S3-Leitlinie und AGO-Empfehlungen evidenzbasiert sind. Die diesjährige 15. St. Gallen-Konsensuskonferenz stand unter dem Motto „Escalating and De-Escalating“, das sich durch alle Therapiebereiche zog, die zur Abstimmung standen. Ziel war es, Patientinnen individuellere Therapieoptionen anzubieten und das Risiko einer Über- bzw. Untertherapie zu vermeiden.
Cardiovascular Responses to Different Resistance Exercise Protocols in Elderly
Authors: Sardeli Amanda , do Carmo Santos Lucas , Ferreira Marina , Gáspari Arthur , Rodrigues Bruno , Cavaglieri Cláudia , Chacon-Mikahil Mara 
Published: September 2017

AbstractIncrease in muscle mass and strength through resistance exercise (RE) has been highly recommended for healthy aging. On the other hand, RE could lead to acute cardiovascular risks prompted mainly by intense blood pressure elevations and cardiac autonomic imbalance. We compared the cardiovascular responses to three different RE protocols performed by 21 healthy elderly on a leg press machine. The protocols tested were high load (80% 1RM) until muscular failure (HL); low load (30% 1RM) until muscular failure (LL); low load, 30 repetitions followed by 3 sets of 15 repetitions, with 50% blood flow restriction (LL-BFR); and a control session (CON). Based on heart rate variability analysis, only LL kept parasympathetic indexes lower than CON at 30 min recovery. By finger photoplethysmography, LL-BFR prompted higher systolic and mainly diastolic blood pressure increments in many sets. The heart rate and cardiac output increase, and total peripheral resistance reduction following exercise were not different among RE protocols. There was no significant post-exercise hypotension and carotid arterial compliance changes. HL seems to be the safer protocol to be recommended for the healthy elderly, because it induces lower blood pressure increments and faster parasympathetic recovery compared to LL and LL-BFR.
Variability Over Time of Normal-Sized Fetal Renal Pelvis During the Second Trimester Scan
Authors: Røset Maria , Blaas Harm-Gerd , Fagerli Tove , Eggebø Torbjørn 
Published: September 2017

Abstract
Purpose To investigate the variability of the normal-sized fetal renal pelvis (≤5 mm) over time and to analyze repeatability of measurements.
Materials and Methods 98 fetal renal pelvises and 49 fetal urinary bladders were analyzed at a gestational age of 17–20 weeks at St. Olavs Hospital, Trondheim, Norway. The anterior-posterior diameter (APD) of the fetal renal pelvis and two diameters of the fetal bladder were measured with an interval of at least 30 min. Intra- and interobserver variations and variations over time and in association with bladder size were investigated.
Results The mean difference in renal pelvis size between the first and second measurements was 0.09 mm (95% CI, −0.09 to 0.26 mm). The variation over time was ≤1 mm in 85% of cases and the renal pelvis was ≤4 mm in both the first and second examinations in 92% of cases. The intraclass correlation coefficient (ICC) was 0.54 (95% CI: 0.31 to 0.69). We did not observe any association between variation of bladder size and variation of APD. The difference in fetal renal pelvis size was ≤1 mm in 70% of observations for the first examiner and 58% for the second examiner. The intraobserver ICCs were 0.71 (95% CI: 0.62–0.78) and 0.60 (95% CI: 0.50–0.70) for the two observers respectively. The interobserver difference was ≤1 mm in 72% of cases and the interobserver ICC was 0.56 (95% CI: 0.34–0.71).
Conclusion The variation of the APD of the fetal renal pelvis over time was small in fetuses with the APD in the lower range and can mainly be explained by intraobserver variation.
Hybrids of Steroid and Nitrogen Mustard as Antiproliferative Agents: Synthesis, In Vitro Evaluation and In Silico Inverse Screening
Authors: Acharya Pratap , Bansal Ranju , Kharkar Prashant 
Published: September 2017

AbstractHybrids of 16E-arylidene steroids and nitrogen mustard have been synthesized and evaluated for their in vitro cytotoxic activity to develop tissue specific antineoplastic agents from steroids. These hybrids displayed specificity towards leukemia cell lines, however somewhat reduced potency was observed in comparison with the earlier reported 16E-arylidene steroids. The in silico reverse screening experiments were employed to find out the probable pharmacological mechanism of these hybrids. Molecular docking studies suggested glucocorticoid receptors as a probable target for the antileukemic action of these steroid-nitrogen mustard hybrids.
Cost-Effectiveness of Mobile App-Guided Training in Extended Focused Assessment with Sonography for Trauma (eFAST): A Randomized Trial
Authors: Nilsson Philip , Todsen Tobias , Subhi Yousif , Graumann Ole , Nolsøe Christian , Tolsgaard Martin 
Published: September 2017

Abstract
Purpose Ultrasound training is associated with a long learning curve and use of substantial faculty resources. Self-directed ultrasound training may decrease the need for faculty-led teaching. Mobile apps seem promising for use in self-directed ultrasound training, but no studies have examined the cost-effectiveness of mobile app-guided training versus traditional formats such as textbook-guided training. This study evaluated the cost-effectiveness of mobile app-guided versus textbook-guided ultrasound training.
Material and methods First-year residents (n = 38) with no previous ultrasound experience were randomized into mobile app-guided versus textbook-guided self-directed ultrasound training groups. Participants completed a transfer test involving four patient cases and a theoretical test on diagnostic accuracy. Two ultrasound experts assessed the residents’ performance using the Objective Structured Assessment of Ultrasound Skills (OSAUS) scale. The costs of developing mobile app and textbook material were calculated and used for the analysis of cost-effectiveness.
Results 34 participants completed the transfer test. There was no statistically significant difference in test performance or diagnostic accuracy between the mobile app-guided (mean-OSAUS 42.3 % [95 %CI38.5 – 46.0 %]) and textbook-guided groups (mean-OSAUS 45.3 % [95 %CI39.3 – 51.3 %]) (d.f. [1.33] = 0.45, p = 0.41). However, development costs differed greatly for each instructional format. Textbook-guided training was significantly more cost-effective than mobile app-guided training (Incremental Cost Effectiveness Ratio -861 967 [95 %CI-1071.7 to-3.2] USD/pct. point change in OSAUS score).
Conclusion Mobile app-guided ultrasound training is less cost-effective than textbook-guided self-directed training. This study underlines the need for careful evaluation of cost-effectiveness when introducing technological innovations for clinical skills training.
Comparison of In Vitro Hepatic Scoparone 7-O-Demethylation between Humans and Experimental Animals
Authors: Fayyaz Anam , Makwinja Seddy , Auriola Seppo , Raunio Hannu , Juvonen Risto 
Published: September 2017

AbstractScoparone is a natural bioactive compound in Chinese herbal medicines. It has numerous pharmacological actions, including liver protective, hypolipidemic, antitumor, and anti-inflammatory effects. The primary metabolism route of scoparone is O-demethylation to scopoletin or isoscopoletin catalyzed by CYP enzymes. The aims of our study were to identify the human CYP enzymes catalyzing scoparone 7-O-demethylation to scopoletin and to compare this oxidation reaction in liver microsomes among different species. A high throughput fluorescent-based assay method was developed to determine the scoparone 7-O-demethylation to scopoletin rate. The rate was 100 – 400 nmol/(min×g protein) in mouse and rabbit liver microsomes, 10 – 20 nmol/(min×g protein) in pig microsomes, 1 – 3 nmol/(min×g protein) in human and less than 1 nmol/(min×g protein) in rat liver microsomes. Human CYP1A1 (Km 13 µM and Vmax 0.8 min−1), CYP1A2 (Km 48 µM and Vmax 0.3 min−1), and CYP2A13 (Km 10 µM and Vmax 22 min−1) were the most efficient catalysts of the reaction. The CYP2A6 selective inhibitor pilocarpine and an antibody against mouse CYP2A5 inhibited scoparone 7-O-demethylation to scopoletin in rabbit, mouse, and pig liver microsomes, indicating involvement of CYP2A enzymes in the reaction. Hepatic scoparone 7-O-demethylation to scopoletin differed between species both with respect to the rate of reaction and catalyzing enzymes. These species differences need to be taken into account when testing scoparone pharmacokinetics in animals and humans.
The Argentine portion of the soybean commodity chain
Authors: Sly Maria Jose Haro 
Published: September 2017

AbstractSince the 1990s the soybean crop has increased in the Southern Cone of Latin America (LA). During this time, Argentina, Brazil, Uruguay, Bolivia and Paraguay have become soybean producers. This phenomenon was influenced by the rising soybean demand from China for use in animal feed as the country changed its diet patterns. South American soybean exports to China constitute an important percentage of the bilateral commerce. Basically, two views can be identified with regard to China’s relations with LA countries. One of them emphasizes opportunities for building mutually beneficial relations and underscores the economic complementarity between both regions. Yet, the critical literature on China and Latin American relations draws attention to the contradictions of this process by highlighting the deepening of neo-extractivism and the expansion of the agricultural frontier. Describing the Argentine portion of the soybean commodity chain this paper will present data to support this critical literature. It depicts the actors, strategies and the degree of monopolization of each of the nodes of soybean production based on secondary data. The article’s key findings are as follows: (1) there is high monopolization and foreignization of soybean production and commercialization; (2) as China has become a global player in genomics and agrochemicals, it has reproduced the same patterns as the core countries; (3) despite the win-win diplomatic statements of the People’s Republic of China, there are important asymmetries in trade, and the Argentine deficits have continually increased; (4) by expanding GM soybean production, Argentina has augmented the concentration of land, primarization and transnationalization of the economy and monoculture; (5) the Cristina F. de Kirchner progressive government failed to stop soybean expansion, and with the drop of the economic growth rate that is associated with the fall of commodity prices combined with the restriction of access to international credits, the government was put in check by various fronts. The distributive conflict contributed to the increasing social confusion that led to a right wing recovery in 2015. Therefore, this article shows that China’s increasing trade with Argentina in the soybean sector follows the existing structure of the global commodity chain and does not offer much space for progressive change in Argentina’s political economy. The data that are presented demystify Chinese win-win statements and counter expectations about China as an alternative globalizer that would bring more benefits to the global South than traditional core countries have.
‘Victim playing’ as a form of verbal aggression in the Czech parliament
Authors: Berrocal Martina 
Published: September 2017

Abstract
As the core of political discourse is the struggle for power and scarce resources, conflict seems to be an essential component of political action and interaction. In addition, conflicts in parliament are manifested in many different ways. They range from disputes during the plenary sessions to more personal attacks in the question time. This paper, however, examines an atypical display of parliamentary discourse, namely a speech by a social democratic MP David Rath, which regarded a vote on his extradition and was delivered on 5 June 2012. This speech obviously did not fulfil the primary function of the parliamentary sessions, i.e. legislating and decision-making. Here the MP was given the opportunity to present his own version of events and ask fellow MPs to maintain his parliamentary immunity. The analysis revealed two intertwining discourse strategies. On the one hand, the MP who is charged with several criminal acts presents himself as a victim of a conspiracy. In that, he aims to divert attention from the criminal case while calling for sympathy and providing self-justification. On the other hand, he uses his time to verbally complain about his arrest, the conditions in which he is held in custody, and the people he holds responsible for his current situation; he uses verbal attacks to undermine and disqualify a number of overt and covert enemies. The key aim of the analysis is to explore how victimhood is constructed in discourse, what discourse strategies are observable at the macro-level and how they are reflected in the discourse structure and in the linguistic style.
“Please protect the Jews”
Authors: Burke Shani 
Published: September 2017

Abstract
This research examined Facebook comments in response to Britain First’s ‘solidarity patrol’ video, in which
Britain First is shown patrolling in Golders Green, North London, ostensibly to show support for the Jewish
community after the shooting in the Kosher supermarket in Paris following the Charlie Hebdo attack. A Critical Discursive
Psychological analysis was conducted on comments. Initial comments were identified as showing support and gratitude towards
Britain First; however, comments became progressively anti-Semitic (e.g. by posing the rhetorical question,
what benefits have Jews brought to Britain?). Results are discussed in terms of how Britain First has managed to
achieve anti-Islamic rhetoric whilst trying to maintain support from the mainstream. This research has identified that discussions
on Facebook have transitioned from Jews being constructed as vulnerable at the hands of Islamic extremism, to Jews being
problematic and the aggressors.
What is conflict? What is aggression? Are these challenging questions?
Authors: Janicki Karol 
Published: September 2017

AbstractThis paper takes up the question of definitions in general and definitions as related to research on language and conflict in particular. I anchor my discussion in the proceedings of the panel ‘Researching and Understanding the Language of Aggression and Conflict’ held at the recent IPrA conference (Antwerp, July 2015). However, I also refer to a selection of articles in theJournal of Language Aggression and Conflict (JLAC)and books on language and conflict. I point to the fact that disagreements about what words such as ‘conflict’’, ‘aggression’, and ‘hate’ mean often lead to unrewarding debates. I trace such disagreements to the philosophical commitments that researchers make (consciously or subliminally). Subsequently, I argue against the essentialist philosophical position, which encourages seeking one satisfactory definition of any concept/term/word. As an alternative, I try to promote a non-essentialist position that encourages us to proceed only with working definitions. Moreover, I advocate working definitions that relate to objects and activities that are as tangible as possible. This way we can avoid unrewarding disputes and contribute to making our research more meaningful and convincing.
Systematic review of computational methods for identifying miRNA-mediated RNA-RNA crosstalk
Authors: Li Yongsheng , Jin Xiyun , Wang Zishan , Li Lili , Chen Hong , Lin Xiaoyu , Yi Song , Zhang Yunpeng , Xu Juan 
Published: September 2017

AbstractPosttranscriptional crosstalk and communication between RNAs yield large regulatory competing endogenous RNA (ceRNA) networks via shared microRNAs (miRNAs), as well as miRNA synergistic networks. The ceRNA crosstalk represents a novel layer of gene regulation that controls both physiological and pathological processes such as development and complex diseases. The rapidly expanding catalogue of ceRNA regulation has provided evidence for exploitation as a general model to predict the ceRNAs in silico. In this article, we first reviewed the current progress of RNA-RNA crosstalk in human complex diseases. Then, the widely used computational methods for modeling ceRNA-ceRNA interaction networks are further summarized into five types: two types of global ceRNA regulation prediction methods and three types of context-specific prediction methods, which are based on miRNA-messenger RNA regulation alone, or by integrating heterogeneous data, respectively. To provide guidance in the computational prediction of ceRNA-ceRNA interactions, we finally performed a comparative study of different combinations of miRNA–target methods as well as five types of ceRNA identification methods by using literature-curated ceRNA regulation and gene perturbation. The results revealed that integration of different miRNA–target prediction methods and context-specific miRNA/gene expression profiles increased the performance for identifying ceRNA regulation. Moreover, different computational methods were complementary in identifying ceRNA regulation and captured different functional parts of similar pathways. We believe that the application of these computational techniques provides valuable functional insights into ceRNA regulation and is a crucial step for informing subsequent functional validation studies.