bluuebunny/crossref_metadata_2025_split huggingface dataset:
Alleviation of Aflatoxin B1‐Induced Genomic Damage by Proanthocyanidins via Modulation of DNA Repair
Authors: Bakheet Saleh A. , Alhuraishi Ahmed M. , Al‐Harbi Naif O. , Al‐Hosaini Khaled A. , Al‐Sharary Shakir D. , Attia Mohammed M. , Alhoshani Ali R. , Al‐Shabanah Othman A. , Al‐Harbi Mohammed M. , Imam Faisal , Ahmad Sheikh F. , Attia Sabry M. 
Published: June 2016

ABSTRACTIn order to study the mechanisms underlying the alleviation of aflatoxin B1‐induced genomic damage by proanthocyanidins (PAs), we examined the modulation of oxidative DNA damage induced by aflatoxin B1 in PAs‐pretreated animals. The effects of PAs on changes in the expression of DNA damage and repair genes induced by aflatoxin B1 were also evaluated in rat marrow cells. Administration of PAs before aflatoxin B1 significantly mitigated aflatoxin B1‐induced oxidative DNA damage in a dose‐dependent manner. Aflatoxin B1 treatment induced significant alterations in the expression of specific DNA repair genes, and the pre‐treatment of rats with PAs ameliorated the altered expression of these genes. Conclusively, PAs protect against aflatoxin B1‐induced oxidative DNA damage in rats. These protective effects are attributed to the antioxidant effects of PA and enhanced DNA repair through modulation of DNA repair gene expression. Therefore, PAs are a promising chemoprotective agent for averting genotoxic risks associated with aflatoxin B1 exposure.
Electrocatalytic Activity of Immobilized Co(II) on Porous Graphene Aerogels
Authors: Bagheri Samira , Ramimoghadam Donya , Mansouri Negar , Bee Abd Hamid Sharifah 
Published: June 2016

AbstractThe highly‐porous graphene aerogel (GA) with BET surface area of 810 m2 g−1 and three‐dimensional structure has been successfully fabricated using the hydrothermal technique. The modified glassy carbon electrode was then prepared by casting the graphene aerogel solution followed by immersing the GA/GCE in Co+2 solution. The results showed that graphene aerogels improved the adsorption ability of the Co (II) ions. The electrocatalysis of oxygen evolution reaction (OER) at the Co‐GA modified glassy carbon elec‐ trode (Co‐GA/GCE) has been investigated using linear sweep voltammetry (LSV) in alkaline solution. The OER was noticeably enhanced at Co‐GA/GCE, representing a negative shift in the LSV curve at the Co‐GA/GCE compared to that obtained at the bare GCE. The high electrocatalytic activity, good reproducibility and low cost of proposed electrode provides desired characteristics of a potential candi‐ date in the industrial water electrolysis process.
One‐step Hydrothermal Synthesis and Assembly of Copper and Silver Nanoparticles to Aggregates in Glyoxal Reduction System
Authors: Talar Abbas Jorsaraei , Ghasemi Hamideh , Rashidi Alimorad , Khodabakhshi Saeed 
Published: June 2016

AbstractA simple hydrothermal process has been developed for the synthesis and assembly of copper and silver nanoparticles to aggregates. The reduction of Cu2+ and Ag+ ions to the zerovalent metal was performed by glyoxal in the absence of any external agent. The produced glyoxylic acid (GA) in the redox process stabi‐ lized metallic copper and silver particles and rendered them oxidation resistant for several months and dispersible in polar organic solvents and water. Detailed nanostructures of synthesized products were characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X‐ray diffraction (XRD). The results demonstrated that assembly of nanoparticles to aggregates and their regularity were dependent on the reaction conditions such as temperature and concentration of the starting material. The Ostwald ripening process was proposed to explain the formation of copper nanoparticles by TEM observation at several times during the reaction. The existence of the surface stabilizing agent was identified by Fourier Transform infrared spectroscopy (FT‐IR) and thermogravimetric analyses (TGA).
Bioremediation of Heavy Metal Ions by Phosphate‐mineralization Bacteria and Its Mechanism
Authors: Qian Chunxiang , Zhan Qiwei 
Published: June 2016

AbstractBioremediation of heavy metal ions by phosphate‐mineralization bacteria (PMB), as a new green and en‐ vironmental method, relies on microbe‐inducing phosphate precipitation and can prevent heavy metal ions from transferring. The growth of PMB was investigated via four aspects respectively — the control of incubation time, pH value, environmental conditions, and heavy metal ions. At the same time, phosphatemineralization precipitations and mechanism of four common kinds of heavy metal ions were analyzed. The experimental results indicated that PMB didn’t grow immediately in the first 5 hours, and they reached to the fastest reproduction rate after 13 hours. The pH value of PMB solution increased gradually from 7.0 to 8.6 when PM0B grew, which plays an important role in the mineralization process. PMB could grow most rapidly at 30 °C, pH of 8 and low concentration of heavy metal ions. It showed that too high or too low temperature and pH, as well as high concentration of heavy metal ions, could inhibit the reproduction of PMB. Stable and large particles phosphate‐mineralization precipitation, whose particle size could be more than 10 microns, were obtained by the process that PMB induced substrate to decompose and thus mineralized heavy metal ions effectively.
Anodized Iron Oxide Nanostructures on Different Carbon Steels for Photoelectrochemical Water Splitting
Authors: Deng Hongda , Huang Mao‐Chia , Weng Wei‐Heng , Lin Jing‐Chie 
Published: June 2016

AbstractIn this study, two different nanostructural iron oxide films were prepared on two kinds of carbon steels (CS) with different contents of impurities via anodization in a mixture of aqueous ammonium fluoride solution and ethylene glycol, respectively, and apply to photoelectrochemical (PEC) water splitting. After annealing, iron oxide nanotubes (NTs) was coated on surface of lower purity CS and iron oxide nanoporous (NPs) was coated on surface of higher purity CS via scanning electron microscope. X‐ray diffraction pattern shows both of samples contain a major phase of α‐Fe2O3 and a slight phase of Fe3O4. Compared with NPs, NTs behaves better absorbance ability in visible spectra range via UV‐visible absorbance spectra. From PEC response, the iron oxide NTs showed higher water splitting performance (0.10 mA/cm2 at 0.4 V vs. Ag/AgCl) than NPs (0.04 mA/cm2 at 0.4 V vs. Ag/AgCl) due to better absorbance, higher car‐ rier concentration and low charge transfer resistance.
Soil structure of arable and non‐arable land in the Western Siberian Grain Belt in Russia—Application of the soil fingerprint code for topsoil characterization
Authors: Störrle Maria , Hagedorn Lisa , Yurtaev Andrey , Brauckmann Hans‐Jörg , Broll Gabriele 
Published: June 2016

AbstractSoil structure is a key indicator for soil quality. Often, a degradation of the soil structure is the result of inappropriate land management. This investigation was carried out in the Western Siberian forest steppe, because soil degradation is an important issue in this part of the Siberian Grain Belt. Therefore, soil structure and further soil properties were examined in the vicinity of the city of Tyumen, Russia. Arable and non‐arable sites were compared by means of the soil fingerprint code (SFC). With SFC the soil surface conditions, chemical and physical parameters of the topsoil were recorded and evaluated in two depths: 0–5 cm and 5–30 cm. The suitability of the SFC to quantify changes of the soil structure of the topsoil was tested. The SFCs of arable and non‐arable sites show that soil structure deteriorates due to arable use. The percentage of granular aggregates decreases and the percentage of subangular blocky and angular blocky aggregates increases. Furthermore, ploughing leads to strong clod formation. Differences in soil structure between 0–5 cm and 5–30 cm soil depth were smaller at arable sites in comparison to non‐arable sites. It was ascertained the SFC is suitable to quantify changes of the soil structure.
Effects of early mycorrhization and colonized root length on low‐soil‐phosphorus resistance of West African pearl millet
Authors: Beggi Francesca , Hamidou Falalou , Hash C. Tom , Buerkert Andreas 
Published: June 2016

AbstractPhosphorus (P) deficiency at early seedling stages is a critical determinant for survival and final yield of pearl millet in multi‐stress Sahelian environments. Longer roots and colonization with arbuscular mycorrhizal fungi (AMF) enhance P uptake and crop performance of millet. Assessing the genotypic variation of early mycorrhization and its effect on plant growth is necessary to better understand mechanisms of resistance to low soil P and to use them in breeding strategies for low P. Therefore, in this study, eight pearl millet varieties contrasting in low‐P resistance were grown in pots under low P (no additional P supply) and high P (+ 0.4 g P pot−1) conditions, and harvested 2, 4, 6, and 8 weeks after sowing (WAS). Root length was calculated 2 WAS by scanning of dissected roots and evaluation with WinRhizo software. AM infection (%) and P uptake (shoot P concentration multiplied per shoot dry matter) were measured at each harvest. Across harvests under low P (3.3 mg Bray P kg−1), resistant genotypes had greater total root length infected with AMF (837 m), higher percentage of AMF colonization (11.6%), and increased P uptake (69.4 mg P plant−1) than sensitive genotypes (177 m, 7.1% colonization and 46.4 mg P plant−1, respectively). Two WAS, resistant genotypes were infected almost twice as much as sensitive ones (4.1% and 2.1%) and the individual resistant genotypes differed in the percentage of AMF infection. AMF colonization was positively related to final dry matter production in pots, which corresponded to field performance. Early mycorrhization enhanced P uptake in pearl millet grown under P‐deficient conditions, with the genotypic variation for this parameter allowing selection for better performance under field conditions.
Can liming reduce barium uptake by agricultural plants grown on sandy soil?
Authors: Myrvang Mona B. , Bleken Marina A. , Krogstad Tore , Heim Michael , Gjengedal Elin 
Published: June 2016

AbstractUptake of barium (Ba) from soil by vascular plants varies among species. Despite the toxicity of soluble Ba compounds to plants, research on mechanisms controlling Ba uptake from natural soils is scarce. This study investigated the treatment effect of lime (CaCO3) added to a sandy soil containing a total of 500 mg Ba kg−1 on uptake and interspecies distribution of Ba in legumes and other cultivated food and feed plants. Nine species of grasses, vegetables, herbs, and legumes were cultivated under controlled conditions in a greenhouse experiment. The plants were harvested at maturity or flowering, dried, milled, and digested with nitric acid using the microwave technique prior to ICP‐MS analysis. All plant species acquired Ba from the soil in considerable amounts, probably due to low Ba adsorption potential of the sandy soil. Shoot tissue concentrations ranged from about 100 (grass) to 600 mg Ba kg−1 (legume) and root concentrations from about 100 (tuber vegetable) to 700 mg kg−1 (legume). Vicia cracca L. (bird vetch) showed an accumulation capacity due to high shoot concentrations of Ba compared to the other species. Higher yield accompanied by a potential dilution effect can partly explain why Trifolium repens L. (white clover), Pisum sativum ssp. arvénse L. (gray pea) and Hordeum vulgare L. (barley) did not display the highest Ba concentrations, but showed the highest Ba uptake from soil. High plant uptake of calcium (Ca) also seemed to enhance Ba uptake, by legumes in particular. However, liming reduced shoot Ba concentrations, particularly of species with low affinity for Ca. The risk of Ba accumulation thus raises toxicity concerns when forage legumes are cultivated in soils containing elevated concentrations of Ba.
Relationships between tinnitus and the prevalence of anxiety and depression
Authors: Bhatt Jay M. , Bhattacharyya Neil , Lin Harrison W. 
Published: June 2016

Objectives/HypothesisQuantify the relationships between tinnitus, and anxiety and depression among adults.Study DesignCross‐sectional analysis of a national health survey.MethodsAdult respondents in the 2007 Integrated Health Interview Series tinnitus module were analyzed. Data for tinnitus symptoms and severity and reported anxiety and depression symptoms were extracted. Associations between tinnitus problems and anxiety, depression, lost workdays, days of alcohol consumption, and mean hours of sleep were assessed.ResultsAmong 21.4 ± 0.69 million adult tinnitus sufferers, 26.1% reported problems with anxiety in the preceding 12 months, whereas only 9.2% of those without tinnitus reported an anxiety problem (P < .001). Similarly, 25.6% of respondents with tinnitus reported problems with depression, whereas only 9.1% of those without tinnitus reported depression symptoms (P < .001). Those reporting tinnitus symptoms as a “big” or “very big” problem were more likely to concurrently report anxiety (odds ratio [OR]: 5.7; 95% CI: 4.0‐8.1; P < .001) and depression (OR: 4.8; 95% CI: 3.5‐6.7; P < .001) symptoms. Tinnitus sufferers reported significantly fewer mean hours of sleep per night (7.00 vs. 7.21; P < .001) and greater mean days of work missed (6.94 vs. 3.79, P < .001) compared to those who did not report tinnitus. Mean days of alcohol consumption between the two groups were not significantly different.ConclusionsTinnitus symptoms are closely associated with anxiety, depression, shorter sleep duration, and greater workdays missed. These comorbidities and sequelae should be recognized and addressed to optimally manage patients with chronic and bothersome tinnitus.Level of Evidence4 Laryngoscope, 2016 127:466–469, 2017
1H DOSY NMR Determination of the Molecular Weight and the Solution Properties of Poly(N‐acryloylmorpholine) in Various Solvents
Authors: Chamignon Cécile , Duret Damien , Charreyre Marie‐Thérèse , Favier Arnaud 
Published: June 2016

1H DOSY NMR provides a simple and convenient method to determine both the molecular weight and the solution properties of poly(N‐acryloylmorpholine) (PNAM) in various organic and aqueous solvents. This technique is used to measure the average diffusion coefficient DPNAM of a library of PNAM samples of increasing molecular weights synthesized by reversible addition fragmentation chain transfer controlled radical polymerization. In all solvents, the highly linear relationship between Log DPNAM and Log Mw yields calibration curves that can be used for the reliable determination of the molecular weight of various types of PNAM samples. In addition, the slope of the calibration curves can be considered as the Flory exponent δ characterizing the solvent–polymer interaction. The measurements show that CDCl3 and D2O are theta solvents for PNAM and that δ slightly decreases in phosphate buffer solution (PBS), pH 7.4, and upon addition of MeOD in D2O.
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Emulsion Inks for 3D Printing of High Porosity Materials
Authors: Sears Nicholas A. , Dhavalikar Prachi S. , Cosgriff‐Hernandez Elizabeth M. 
Published: June 2016

Photocurable emulsion inks for use with solid freeform fabrication (SFF) to generate constructs with hierarchical porosity are presented. A high internal phase emulsion (HIPE) templating technique was utilized to prepare water‐in‐oil emulsions from a hydrophobic photopolymer, surfactant, and water. These HIPEs displayed strong shear thinning behavior that permitted layer‐by‐layer deposition into complex shapes and adequately high viscosity at low shear for shape retention after extrusion. Each layer was actively polymerized with an ultraviolet cure‐on‐dispense (CoD) technique and compositions with sufficient viscosity were able to produce tall, complex scaffolds with an internal lattice structure and microscale porosity. Evaluation of the rheological and cure properties indicated that the viscosity and cure rate both played an important role in print fidelity. These 3D printed polyHIPE constructs benefit from the tunable pore structure of emulsion templated material and the designed architecture of 3D printing. As such, these emulsion inks can be used to create ultra high porosity constructs with complex geometries and internal lattice structures not possible with traditional manufacturing techniques.
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A Virtual Screening Study for Lactate Dehydrogenase 5 Inhibitors by Using a Pharmacophore‐based Approach
Authors: Tuccinardi Tiziano , Poli Giulio , Corchia Isacco , Granchi Carlotta , Lapillo Margherita , Macchia Marco , Minutolo Filippo , Ortore Gabriella , Martinelli Adriano 
Published: June 2016

AbstractInhibitors of human lactate dehydrogenase 5 (hLDH5) are promising therapeutic agents against cancer. This enzyme is generally found to be overexpressed in most invasive cancer cells and is linked to their vitality especially under hypoxic conditions. In this study, with the aim of identifying new hLDH5 inhibitors, a receptor‐based pharmacophore modeling approach has been tested and, in order to verify the reliability of the reported approach, the Gold and Platinum database from Asinex were filtered. The top‐ranked compounds were experimentally tested for their hLDH5 inhibition activity and enzymatic assays revealed that, among the ten selected compounds, two proved to inhibit the enzyme activity with Ki values in the micromolar range (Ki=33.1–76.7 μM).
Training at non‐damaging intensities facilitates recovery from muscle atrophy
Authors: Itoh Yuta , Murakami Taro , Mori Tomohiro , Agata Nobuhide , Kimura Nahoko , Inoue‐Miyazu Masumi , Hayakawa Kimihide , Hirano Takayuki , Sokabe Masahiro , Kawakami Keisuke 
Published: June 2016

ABSTRACTIntroduction: Resistance training promotes recovery from muscle atrophy, but optimum training programs have not been established. We aimed to determine the optimum training intensity for muscle atrophy. Methods: Mice recovering from atrophied muscles after 2 weeks of tail suspension underwent repeated isometric training with varying joint torques 50 times per day. Results: Muscle recovery assessed by maximal isometric contraction and myofiber cross‐sectional areas (CSAs) were facilitated at 40% and 60% maximum contraction strength (MC), but at not at 10% and 90% MC. At 60% and 90% MC, damaged and contained smaller diameter fibers were observed. Activation of myogenic satellite cells and a marked increase in myonuclei were observed at 40%, 60%, and 90% MC. Conclusions: The increases in myofiber CSAs were likely caused by increased myonuclei formed through fusion of resistance‐induced myofibers with myogenic satellite cells. These data indicate that resistance training without muscle damage facilitates efficient recovery from atrophy. Muscle Nerve 55: 243–253, 2017
Oncotargets GD2 and GD3 are highly expressed in sarcomas of children, adolescents, and young adults
Authors: Dobrenkov Konstantin , Ostrovnaya Irina , Gu Jessie , Cheung Irene Y. , Cheung Nai‐Kong V. 
Published: June 2016

AbstractBackgroundGD2 and GD3 are the tumor‐associated glycolipid antigens found in a broad spectrum of human cancers. GD2‐specific antibody is currently a standard of care for high‐risk neuroblastoma therapy. In this study, the pattern of GD2 and GD3 expression among pediatric/adolescent or young adult tumors was determined, providing companion diagnostics for targeted therapy.MethodsNinety‐two specimens of human osteosarcoma (OS), rhabdomyosarcoma (RMS), Ewing family of tumors, desmoplastic small round cell tumor (DSRCT), and melanoma were analyzed for GD2/GD3 expression by immunohistochemistry. Murine monoclonal antibody 3F8 was used for GD2 staining, and R24 for GD3. Staining was scored according to both intensity and percentage of positive tumor cells from 0 to 4.ResultsBoth gangliosides were highly prevalent in OS and melanoma. Among other tumors, GD3 expression was higher than GD2 expression. Most OS samples demonstrated strong staining for GD2 and GD3, whereas expression for other tumors was highly variable. Mean intensity of GD2 expression was significantly more heterogeneous (P < 0.001) when compared to GD3 across tumor types. When assessing the difference between GD2 and GD3 expression in all tumor types combined, GD3 expression had a significantly higher score (P = 0.049). When analyzed within each cancer, GD3 expression was significantly higher only in DSRCT (P = 0.002). There was no statistical difference in either GD2 or GD3 expression between primary and recurrent sarcomas.ConclusionGD2/GD3 expression among pediatric solid tumors is common, albeit with variable level of expression. Especially for patients with sarcoma, these gangliosides can be potential targets for antibody‐based therapies.
Unusual serological findings associated with ceftriaxone‐induced immune hemolytic anemia in a child with disseminated low‐grade glioma
Authors: Pecker L. H. , Timsar A. , Pary P. P. , Denomme G. A. , Criss V. R. , Luban N. L. C. , Hwang E. I. , Wong E. C. C. 
Published: June 2016

AbstractCeftriaxone‐induced immune hemolytic anemia (CIHA) is the second most common cause of drug‐induced hemolytic anemia. Prompt recognition of this drug reaction is essential because brisk hemolysis can be deadly. The extent to which ceftriaxone antibodies persist after CIHA is unknown; rechallenging patients who have experienced CIHA is not recommended. We report a case of CIHA in a neurooncology patient, which is the first to show anticeftriaxone antibodies with Rh specificity and persisted for 8 months after the drug reaction. These findings have implications for understanding the mechanism of CIHA.
Tailored hydrolytically stable polyacid gels based on curable poly(acrylic acid)s and bisacrylamides
Authors: Lampe Ulrich , Maier Maximilian , Klee Joachim E , Ritter Helmut 
Published: June 2016

AbstractPoly(acrylic acid)s (PAAs) with curable methacrylamide moieties as well as bisacrylamide crosslinkers are described as components for well‐defined hydrogels with increased hydrolytic resistance. PAAs with tethered curing moieties of different alkyl spacer lengths (−(CH2)n−, n = 2, 3, 6 or 8) were prepared via copolymerization of one‐sided methacrylated diamines with protected acrylic acid, followed by polymer‐analogous methacrylation and deprotection. Bisacrylamide crosslinkers were synthesized by acrylation of diamines with different cores and N‐substitutes like allyl, cyclopropyl or propyl groups. Both components were subsequently combined for the formation of novel amide based hydrogels. Network densities of the obtained gels were elucidated by rheokinetic investigations. © 2016 Society of Chemical Industry