bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vitamin D supplements reduce depressive symptoms and cardiac events in heart failure patients with moderate to severe depressive symptoms
Authors: Song Eun Kyeung , Wu Jia-Rong , Moser Debra K , Kang Seok-Min , Lennie Terry A 
Published: August 2017

Background: Depressive symptoms and vitamin D deficiency predict cardiac events in heart failure patients, but whether vitamin D supplements are associated with depressive symptoms and cardiac events in heart failure patients remains unknown. Purpose: The purpose of this study was to compare the association of vitamin D supplement use with depressive symptoms and cardiac events in heart failure patients with mild or moderate to severe depressive symptoms. Methods: A total of 177 heart failure patients with depressive symptoms (Patient Health Questionnaire-9 score ≥5) completed a three-day food diary to determine dietary vitamin D deficiency. Patients were split into four groups by dietary vitamin D adequacy versus deficiency and vitamin D supplement use versus non-use. The Patient Health Questionnaire-9 was used to reassess depressive symptoms at six months. Data on cardiac events for up to one year and vitamin D supplement use were obtained from patient interview and medical record review. Hierarchical linear and Cox regressions were used for data analysis. Results: Sixty-six patients (37.3%) had dietary vitamin D deficiency and 80 (45.2%) used vitamin D supplements. In patients with moderate to severe depressive symptoms, the group with dietary vitamin D deficiency and no supplements had the highest Patient Health Questionnaire-9 score at six months (β=0.542, p<0.001) and shortest cardiac event-free survival ( p<0.001) among the four groups, the group with dietary vitamin D deficiency and no supplements didn’t have the highest Patient Health Questionnaire-9 score at six months and shortest cardiac event-free survival in patients with mild depressive symptoms. Conclusions: Vitamin D supplements predicted lower depressive symptoms and reduced cardiac events for patients with moderate to severe depressive symptoms. Vitamin D deficiency was associated with higher risk of shorter cardiac event-free survival in heart failure patients regardless of vitamin D supplementation.
A retrospective review of patients with massive and submassive pulmonary embolism treated with AngioJet rheolytic thrombectomy with decreased complications due to changes in thrombolytic use and procedural modifications
Authors: Das Sundeep , Das Nikhil , Serota Harvey , Vissa Sriram 
Published: August 2017

Objectives A retrospective review of treatment of patients with massive or submassive pulmonary embolism (PE) using AngioJet rheolytic thrombectomy (ART) system with procedural modifications to improve on the previously reported outcomes. Materials and Methods Thirteen patients underwent emergent pulmonary artery thrombectomy for massive and submassive PE using ART with pharmacological and procedural modification, in comparison to prior reports. The modifications included the selective use of the Solent Omni AngioJet device in all subjects, distal contrast angiography via the AngioJet catheter before device activation, and limited short run times. Thrombolytic therapy was not used in any patient. Patients were monitored for short- and long-term outcomes. Long-term clinical follow-up and evaluation for persistent pulmonary hypertension with echocardiography was performed. Results The pharmacological and procedural modifications resulted in a favorable clinical response without any major complications and without any mortality. Procedure-related anemia (mean hemoglobin drop of 0.49 g/dl) was the only significant minor complication noted. There were no bleeding complications and no transfusion requirement. On a six-month follow-up, there was no mortality, and there were significant reductions in the pulmonary artery pressures. Conclusion Major and minor complications were reduced compared to prior reports using ART. A modified ART approach towards treatment of high-risk PE appears promising both in terms of efficacy and safety.
Correlates and prognostic impact of new-onset heart failure after ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: insights from the INFUSE-AMI trial
Authors: Giustino Gennaro , Redfors Björn , Brener Sorin J , Kirtane Ajay J , Généreux Philippe , Maehara Akiko , Dudek Dariusz , Neunteufl Thomas , Metzger D Christopher , Crowley Aaron , Mehran Roxana , Gibson C Michael , Stone Gregg W 
Published: August 2017

Background: The determinants and significance of early (30-day) heart failure symptoms after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI) remain unclear. We investigated the clinical and imaging correlates of early post-discharge heart failure in patients with STEMI, and evaluated its impact on clinical outcomes. Methods: Patients from the INFUSE-AMI trial were categorized according to New York Heart Association (NYHA) functional classification at their 30-day visit (NYHA class ≥2 versus 1). Independent correlates of NYHA class ≥2 were determined by multivariable logistic regression. A landmark analysis beyond 30 days was performed to assess the impact of 30-day NYHA class ≥2 on 1-year risk of death or hospitalization for heart failure. Results: Among 402 patients enrolled in the INFUSE-AMI trial with data on NYHA class at 30 days, 76 (18.9%) had NYHA class ≥2. Independent correlates of 30-day NYHA class ≥2 were age, Killip class ≥2 at presentation, heart rate at presentation, intraprocedural no-reflow, and 30-day infarct size (% total ventricular mass). After adjustment for infarct size, patients with NYHA class ≥2 remained at higher risk of death or hospitalization for heart failure at 1-year follow-up compared to those in NYHA class 1 (11.8% vs. 2.8%, adjusted hazard ratio 3.78, 95% confidence interval 1.16–12.22, P=0.03). Conclusions: Clinical, procedural, and imaging variables predict the development of clinical heart failure after primary percutaneous coronary intervention in patients with STEMI. Early post-discharge heart failure symptoms identify a high-risk patient cohort for subsequent heart failure hospitalization and death, independent of infarct size. Trial Registration: ClinicalTrials.gov ; NCT00976521
Combat Exposure Severity Is Associated With Reduced Cortical Thickness in Combat Veterans: A Preliminary Report
Authors: Averill Lynnette A. , Abdallah Chadi G. , Pietrzak Robert H. , Averill Christopher L. , Southwick Steven M. , Krystal John H. , Harpaz-Rotem Ilan 
Published: August 2017

Background Chronic stress and related physiological responses are known to have deleterious effects on neural integrity. Combat exposure is a notoriously pathogenic stressor, and with over 2 million U.S. troops deployed to active combat zones since 2001, there is an urgent need to advance our understanding of its potential neural impact. Previous evidence suggests structural alterations in posttraumatic stress disorder (PTSD) and more recent studies have explored cortical thinning specifically. This preliminary study investigates the impact of combat exposure on cortical thickness, controlling for history of early life stress and age. Methods Twenty-one combat-exposed Veterans with PTSD and 20 non-PTSD combat-exposed controls (mean age 32.7) completed the Combat Exposure Scale, Childhood Trauma Questionnaire, and structural magnetic resonance imaging in a Siemens 3T TIM trio system. General linear model was used to examine the effect of combat exposure on cortical thickness, controlling for early life trauma exposure and age using cluster-wise correction ( p < 0.05). Results This preliminary study found a negative correlation between combat exposure severity (CES) and cortical thickness in the left superior temporal and left rostral middle frontal regions, as well as an interaction between PTSD diagnosis status and CES, in the superior temporal/insular region showing a stronger negative correlation between CES and cortical thickness in the non-PTSD group. Conclusions Though caution should be taken with interpretation given the preliminary nature of the findings, the results indicate combat exposure may affect cortical structure beyond possible alterations due to early life stress exposure or PTSD psychopathology. Though replication in larger samples is required, these results provide useful information regarding possible neural biomarkers and treatment targets for combat-related psychopathology as well as highlighting the pathogenic effects of combat.
HDAC6 inhibition upregulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies
Authors: Bobrowicz Malgorzata , Dwojak Michal , Pyrzynska Beata , Stachura Joanna , Muchowicz Angelika , Berthel Elise , Dalla-Venezia Nicole , Kozikowski Mieszko , Siernicka Marta , Miazek Nina , Zapala Piotr , Domagala Antoni , Bojarczuk Kamil , Malenda Agata , Barankiewicz Joanna , Graczyk-Jarzynka Agnieszka , Zagozdzon Agnieszka , Gabrysiak Magdalena , Diaz Jean-Jacques , Karp Marta , Lech-Maranda Ewa , Firczuk Malgorzata , Giannopoulos Krzysztof , Efremov Dimitar G. , Laurenti Luca , Baatout Dunja , Frenzel Lukas , Malinowska Agata , Slabicki Mikolaj , Zenz Thorsten , Zerrouqi Abdessamad , Golab Jakub , Winiarska Magdalena 
Published: August 2017

Key Points
HDAC6 inhibition represents a novel strategy to improve the efficacy of anti-CD20 mAbs. HDAC6 inhibition increases CD20 levels by enhancing CD20 protein synthesis without affecting the gene expression.
Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions
Authors: Martín-Pardillos Ana , Tsaalbi-Shtylik Anastasia , Chen Si , Lazare Seka , Os Ronald P. van , Dethmers-Ausema Albertina , Fakouri Nima Borhan , Bosshard Matthias , Aprigliano Rossana , Loon Barbara van , Salvatori Daniela C. F. , Hashimoto Keiji , Dingemanse-van der Spek Celia , Moriya Masaaki , Rasmussen Lene Juel , de Haan Gerald , Raaijmakers Marc H. G. P. , de Wind Niels 
Published: August 2017

Key Points
Tolerance of oxidative DNA lesions ensures the genomic and functional integrity of hematopoietic stem and precursor cells. Endogenous DNA damage–induced replication stress is associated with mitochondrial dysfunction.
Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib
Authors: Miller Cecelia R. , Ruppert Amy S. , Heerema Nyla A. , Maddocks Kami J. , Labanowska Jadwiga , Breidenbach Heather , Lozanski Gerard , Zhao Weiqiang , Gordon Amber L. , Jones Jeffrey A. , Flynn Joseph M. , Jaglowski Samantha M. , Andritsos Leslie A. , Blum Kristie A. , T. Awan Farrukh , Rogers Kerry A. , Grever Michael R. , Johnson Amy J. , Abruzzo Lynne V. , Hertlein Erin K. , Blachly James S. , Woyach Jennifer A. , Byrd John C. 
Published: August 2017

Key Points
Pretreatment near-tetraploidy is associated with advanced Rai stage, deletion of 17p, and complex karyotype. Pretreatment near-tetraploidy is an independent risk factor for ibrutinib discontinuation via Richter transformation.
Cross‐cultural adaptation and validation of Spanish version of The Foot and Ankle Ability Measures (FAAM‐Sp)
Authors: Cervera‐Garvi Pablo , Ortega‐Avila Ana Belen , Morales‐Asencio Jose Miguel , Cervera‐Marin Jose Antonio , Martin Rob Roy , Gijon‐Nogueron Gabriel 
Published: August 2017

AbstractBackgroundThe Foot and Ankle Ability Measure (FAAM) is a Patient Reported Outcome (PRO) commonly used to determine the effectiveness of therapeutic interventions for patients with foot and ankle pathologies and associated impairments of body function and structure, activity limitations, and participation restrictions. The aim of this study was to cross‐culturally adapt the FAAM into Spanish.MethodsCross‐cultural adaptation was performed according to the international guidelines of the International Society for Pharmacoeconomics and Outcomes Research. Cronbach's alpha, test re‐test reliability, and item‐total and inter‐item correlations were analyzed. Confirmatory factor analysis (CFA) was carried out to test construct validity. Pearson correlations were calculated to assess the convergent validity between FAAM and EuroQol‐5.ResultsSpanish data set comprised 194 patients, with a mean age of 38.45 (16.04) and 130 (67.1%) were female, seeing a podiatrist with a wide variety of foot and ankle related disorders. CFA was carried out to test structure matrix (which has three factors). The test–retest reliability was high with global ICC of 0.95 (95% CI: 0.93 to 0.98). A 15 items version of the FAAM‐Sp Activities of Daily Living (ADL) obtained the best fit: relative chi‐square (x2/df) of 2.46, GFI 0.90 CFI 0.95, NFI 0.93, and RMSEA 0.08 (90% CI 0.04 to 0.09). For exploratory factor analysis for the FAAM‐Sp Sport, a one factor solution was obtained, which explained 76.70% of total variance. CFA corroborated this model with an excellent goodness of fit:: relative chi‐square (x2/df) of 0.80, GFI 0.99 CFI 1.00, NFI 0.99, and RMSEA 0.00 (90% CI 0.00 to 0.75).ConclusionsThis study validated a new 15‐item FAAM‐Sp ADL and FAAM‐Sp Sport subscales, which can be used as a self‐reported outcome measure in clinical practice and research for patients resident in Spain whose main language is Spanish.
Endoscopically-assisted transmastoid approach to the geniculate ganglion and labyrinthine facial nerve
Authors: Jufas Nicholas , Bance Manohar 
Published: August 2017

Background Endoscopic transcanal approaches to the facial nerve allow excellent exposure of the tympanic facial nerve. This approach becomes limited when access is required to the more proximal geniculate ganglion and labyrinthine portion of the facial nerve. The aim of this report was to determine the feasibility of a transmastoid endoscopically assisted approach to the geniculate ganglion and labyrinthine facial nerve. This is an endoscopic cadaveric dissection and video review at a university anatomical laboratory. Methods A total of 12 endoscopic cadaveric dissections were performed. A cortical mastoidectomy and perilabyrinthine air cell removal was performed using an operating microscope. Beyond this, dissection was performed with an endoscope. Results In all dissections, an endoscopically assisted transmastoid approach allowed complete access to the geniculate ganglion, and at least 1.5 mm of the distal labyrinthine facial nerve. Further transcrusal drilling through the anterior crus of the superior semicircular canal allowed access to the entire labyrinthine facial nerve. Conclusions The entire geniculate ganglion and labyrinthine facial nerve is difficult to access with microscopic techniques. Adding endoscopic visualization allows for complete visualization of the geniculate ganglion. Clinical reports will further strengthen these preliminary cadaveric results.
An independent assessment of reliability of the Melbourne Cerebral Palsy Hip Classification System
Authors: Shrader M. W. , Koenig A. L. , Falk M. , Belthur M. , Boan C. 
Published: August 2017

Purpose Neuromuscular (NM) hip dysplasia is common in patients with cerebral palsy (CP). Traditionally, migration percentage (MP) has been used to measure the severity of NM hip dysplasia; however, the MP has some limitations. The purpose of this study is to determine the intra- and inter-reliability of the Melbourne Cerebral Palsy Hip Classification System in the typical paediatric population of patients with CP. Methods A total of 65 anteroposterior pelvis radiographs in patients (age range 12 years to 21 years) with CP spanning all grades (I to VI) of the classification system were identified and collected for analysis in this institutional review board approved study. Four paediatric orthopaedic surgeons and one orthopaedic surgical resident classified each radiograph according to the Melbourne system. Then, at least four weeks later, the raters repeated the process with a re-randomised order of radiographs. Statistical analysis was performed using the intraclass correlation coefficient (ICC) where < 0 denotes poor agreement and > 0.8 indicates almost perfect agreement. Results The interobserver reliability was found to be excellent with the ICC of 0.853 (0.813 to 0.887) and 0.839 (0.795 to 0.877). The intraobserver reliability was also found to be excellent with the ICC in the range of 0.838 to 0.933 among the raters. Subgroup analysis indicated no differences in the reliability of observers based on clinical experience. Conclusion This study independently demonstrates that the Melbourne Cerebral Palsy Hip Classification System for NM hip dysplasia in patients with CP can be reliably used for communication among various healthcare providers and research and epidemiological purposes.
NUVEM DE PALAVRAS E MAPA CONCEITUAL: ESTRATÉGIAS E RECURSOS TECNOLÓGICOS NA PRÁTICA PEDAGÓGICA
Authors: Prais Jacqueline Lidiane de Souza , Rosa Vanderley Flor da 
Published: August 2017

Este trabalho discute a utilização da nuvem de palavras e do mapa conceitual como estratégias pedagógicas a partir do uso de recursos tecnológicos como o Wordle® e CmapTools®. A aplicação dessas ferramentas tecnológicas ocorreu em um curso de extensão visando à formação de professores para a inclusão e, portanto, foram empregadas para ensinar e para avaliar a apropriação do conteúdo desse processo formativo: a inclusão educacional. A questão principal de investigação é: de que forma licenciandas em Pedagogia percebem a utilização da nuvem de palavras e do mapa conceitual como atividades didáticas? Para isso, foi utilizada a pesquisa do tipo intervenção pedagógica, a coleta de dados feita por meio de questionários, diário de campo e atividades desenvolvidas, sendo os dados interpretados pela análise de conteúdo. Os resultados indicaram que as atividades didáticas promoveram a familiaridade com o uso de TIC no processo de ensino e de aprendizagem, e que contribuíram para a sistematização e a apropriação do conteúdo do curso de extensão como uma ação didática formativa.
Effect of High Temperature Intermittent Drying on Rice Seed Viability and Vigor
Authors: Wang Pan , Li Dong , Wang Li-jun , Adhikari Benu 
Published: August 2017

Abstract
This work aimed at determining whether high temperature intermittent drying followed by tempering at ambient temperature could preserve the seed viability and vigor. Japonica and Indica rice seeds with 21.2 % and 22.6 % wet moisture contents (w.b.) were dried at 50 ºC and 60ºC for either 5, 10, 15 or 20 minutes, followed by tempering at 25ºC for 45 minutes. Each drying cycle was repeated until the rice seeds were dried to 12.0 % (w.b.). The drying rate was improved and the total in-dryer time was reduced in the intermittent drying when compared to continuous drying, due to the tempering process. The seed vigor was significantly reduced by intermittent drying at 60 °C with all exposure times, although the seed still kept the ability to germinate for both rice cultivars. The intermittent drying at 50 ºC for 5 minutes per drying cycle preserved the seed vigor of Japonica rice well, while in Indica rice, the intermittent drying at 50 ºC up to 20 minutes could still be able to maintain the seed vigor.
Introduction: Language and globalization in South and Central Asian spaces
Authors: Bolander Brook , Mostowlansky Till 
Published: August 2017

AbstractIn this introduction, we outline our approach to the two main themes this interdisciplinary special issue brings together – language and globalization, and South and Central Asian spaces. Arguing for the importance of exploring these topics from multiple, complementary disciplinary angles (sociolinguistic, anthropological and historical), we delineate a conceptualization of language and globalization which both acknowledges the inextricable relationship between language (use and ideology) and processes of globalization (past and present); as well as the challenges this relationship poses for linguistic research. We thereby adopt a viewpoint which underscores the importance of not
The Role of Copyright in Creative Industry Development
Authors: Pager Sean A. 
Published: August 2017

AbstractDoes copyright foster the development of creative industries in developing countries? Drawing on case studies from Nigeria, India, and China, this Article sheds some light on these questions. It argues that copyright offers distinct advantages over alternative models. Moreover, copyright law need not function as a monolithic force. Copyright norms can govern some aspects of industry operations, while remaining largely absent in other domains. However, as industries develop, the benefits of copyright become more salient and the logic of copyright formalization exerts a gravitational pull.
Stability via successive approximation for nonlinear implicit fractional differential equations
Authors: Kucche Kishor D. , Sutar Sagar T. 
Published: August 2017

Abstract
In this paper we are concerned with nonlinear implicit fractional differential equations with initial conditions. We prove the existence and uniqueness results by using modified version of contraction principle. Further, our prime aim is to present various Ulam-Hyers stability and Eα-Ulam-Hyers stability results via successive approximation method.
A review of the comparative study of Mo Yan and Faulkner in China
Authors: Huang Xiuguo 
Published: August 2017

Abstract
Mo Yan’s multi-layered and allegorical tales were highly inspired by William Faulkner. Mo Yan’s semi-fictional Gaomi Northeast Township was often linked to William Faulkner’s fictional Yoknapatawpha, and he himself was extolled by the Chinese scholars to be “China’s Faulkner.” Inside China, there have emerged a great number of comparative studies on Faulkner and Mo Yan, which are usually conducted from the perspectives of literary forms, native-soil complex, attitudes towards tradition, the influence of local culture, and so on. However, despite the strong record of research on these two writers in China, there is still room for improvement in the study, for after the initial stage of the superficial and sporadic comparison between individual works, the comparative study of Faulkner and Mo Yanis in pressing need of comprehensive and systematic research of these criticisms.