bluuebunny/crossref_metadata_2025_split huggingface dataset:
A ORIGEM DAS BORDAS DE MIRMEQUITA NOS XENOCRISTAIS DE FELDSPATO POTÁSSICO EM ROCHAS MÁFICAS E HÍBRIDAS DO MACIÇO SANTA ANGÉLICA – ES
Authors: Zanon Marcela Lopes , Chaves Alexandre de Oliveira , Gabrig Caio Vinícius Turbay 
Published: January 2016

O Complexo Intrusivo Santa Angélica faz parte de um dos mais importantes plútons de magmatismo bimodal da Suíte G5, geradano estágio pós-colisional (530 – 490 Ma) da Orogênese Brasiliana, esta que deu origem ao Orógeno Araçuaí-Ribeira. Este corpo intrusivo érepresentado por litotipos félsicos e máficos, sendo estes separados por uma extensa zona de mistura de magmas onde ocorrem rochashíbridas. O estudo petrográfico microscópico de rochas máficas e híbridas com xenocristais de K-feldspato indicou bordas de reação nestesgrãos constituídas exclusivamente por mirmequita. A fim de compreender quais reações xenocristal-líquido desencadearam a formaçãodestas bordas mirmequíticas, foram realizadas análises em microssonda que, posteriormente foram interpretadas juntamente ao estudopetrográfico microscópio. Os resultados indicaram que as porções máficas e híbridas ainda estavam em estado líquido quando houve amigração dos xenocristais que, ao reagirem com o material magmático, desencadearam uma reação envolvendo íons de Ca e Naresultando na formação de uma borda constituída por mirmequita.Palavras-chave: Santa Angélica, mirmequita, xenocristal. ABSTRACTTHE ORIGIN OF MIRMEKITIC BORDERS IN K-FELDSPAR XENOCRYSTALS FROM MAFIC AND HYBRID ROCKS OF SANTA ANGÉLICAMASSIVE - ES - The Santa Angelica Intrusive Complex is part of the more importants plutons of the G5 Suite of bimodal magmatism,intrudet in the post-collisional (530 - 490 Ma) of the Brasiliano orogeny that made the Orogen Araçuaí-Ribeira. This pluton is representedby felsic and mafic rocks, which are separated by an extensive zone of magma mixing and mingling with the occurrence of hybrid rocks. Thepetrographic study of the hybrid and mafic rocks with K-feldspar xenocrysts indicates their edges reaction consist exclusively of mirmekite.In order to understand how xenocristal-liquid reactions triggered the formation of these edges, microprobe analyzes were performed,These data and microscopic results were interpreted together. The results indicated that when the xenocrysts migrated to the mafic andhybrids rocks they were still in the liquid state, resulting in the reaction between the xenocrysts and the Ca and Na ions of the magma thatformatted the myrmekite edge.Keywords: Santa Angelica, myrmekite, xenocristal.
Fontes manuscritas sobre a língua geral da Amazônia escritas por jesuítas tapuitinga (século XVIII)
Authors: Barros Candida , Monserrat Ruth Maria 
Published: January 2016

RESUMO:
O trabalho apresenta o levantamento de documentos setecentistas sobre a língua geral com indícios de terem sido escritos por um pequeno grupo de jesuítas da Europa Central (tapuitinga) que chegou à Amazônia entre 1750 e 1753 e aponta algumas das estratégias de aprendizado da língua geral empregadas por eles.

PALAVRAS-CHAVE:
Língua geral; dicionários; catecismos; jesuítas da Europa Central
História da língua portuguesa e historiografia linguística no Brasil em cinco gramáticas do século XIX
Authors: Coelho Olga Ferreira , Danna Stela Maris Detregiacchi Gabriel 
Published: January 2016

RESUMO:
Neste artigo, avaliamos como cinco gramáticas brasileiras – Ribeiro (1881), Pacheco & Lameira (1887), Ribeiro (1889[1887]), Carneiro Ribeiro (1890) e Maciel (1902[1894]) – publicadas na segunda metade do século XIX, descrevem o português do Brasil. Nossa análise aponta que, além de relevantes para a Historiografia Linguística, esses materiais constituem fontes essenciais para o estudo da História da Língua Portuguesa no Brasil.

PALAVRAS-CHAVE:
Historiografia Linguística, português brasileiro, gramaticografia brasileira, século XIX.
Hacia un nuevo Estado desarrollista: desafíos para América Latina
Authors: Zurbriggen Cristina , Travieso Emiliano 
Published: January 2016

La primera década del siglo xxi constituyó una coyuntura de transformaciones en el mapa político de América Latina. Después de una larga hegemonía de las fuerzas políticas de derecha y centro-derecha, las de izquierda y centro-izquierda —un conjunto muy heterogéneo— conquistaron los gobiernos de la región con un discurso crítico del modelo neoliberal, que subrayaba el papel del Estado como actor clave del proceso de desarrollo. En este escenario, la crisis de 2008 profundizó este debate, enfocando la relación del Estado con las élites y el capital extranjero, así como en su capacidad de articular una estrategia de desarrollo para construir sociedades más prósperas y justas. Este artículo revisita los dos paradigmas del papel del Estado en los procesos de desarrollo: el modelo neoliberal y el desarrollista, a la luz de enfoques teóricos de disciplinas como la ciencia política, la historia económica y la economía del desarrollo. Se concluye que el gran desafío de una nueva teoría y práctica del Estado en América Latina se encuentra en construir coaliciones desarrollistas amplias que permitan contrapesar los intereses centrífugos de las élites locales y las corporaciones trasnacionales.
Online learning community software to support success in project teams
Authors: Thoms Brian Patrick 
Published: January 2016

<p>In this research we explore aspects of social interaction and community as they relate to success in project-based courses. Using specialized online community software consisting of social networking technologies and project-based wikis, project teams are able to collaborate and interact as they progress towards project milestones. Our study underscores the importance of sustained engagement as a means for fostering high levels of community and how these levels relate to project motivation and, ultimately, project success. Guided by a theoretical model that explains how individuals collaborate within online communities, we measure member perceptions of the software before and after our intervention. Survey results found that online learning community (OLC) software can successfully support learning and social interaction. These results are supported by a social network analysis (SNA), which shows high levels of individual engagement across the project lifecycle.</p><p> </p><p> Keywords: social networking, online learning community, wiki, project management, capstone project.</p>
Evaluation of Acid Fracturing by Integrated Pressure Analysis and 3D Simulation: A Field Application for Multi-Stage Stimulation in Horizontal Wells
Authors: Ueda K. , Zhang W. , Zhu D. , Hill A. D. , Zhang Fuxiang , Yang Xiangtong 
Published: January 2016

Abstract
Multi-stage acid fracturing in a tight carbonate formation can be an alternative to propped fracturing as a relatively cost-effective completion treatment. However the success of the treatment depends on many factors as to whether enough conductivity by acid etching has been created, and weather the selected chemical treatment has worked well in-situ under the specific geologic environment. Thus, observation and evaluation of past practice is important to develop further optimal stimulation procedures. In this paper, an integrated methodology to conduct performance evaluation of multi-stage acid fracturing treatment in a horizontal well is presented. The method is applied to a field case in Tarim Basin in China.
The integrated procedure starts with obtaining closure pressure and the formation breakdown pressure. Bottomhole treating pressure is then estimated from surface treating pressure in cases if it is not measured directly. A treatment pressure history match is then conducted to estimate the fracture geometry using commercial software. A 3-D acid fracture conductivity profile is generated using the in-house acid fracture simulator. Then using the reservoir face pressure and the acid fracture conductivity profile obtained by the acid fracture simulator, the cross-sectional flowing area created by acid fracturing fluid is estimated using pressure transient analysis. Evolution of fracture extension and acid etching during the stimulation is calculated assuming a bilinear flow regime. After production starts, a linear flow diagnostic approach provides the cross-sectional area flowing that has the flow from the matrix. This enables us to compare flowing cross-sectional area with induced area by the stimulation, which is defined as treatment efficiency.
A field application based on the proposed procedure shows the effectiveness of the approach. The integrated approach provides engineers with additional information as to whether the designed acid fracturing has been performed appropriately under high closure stress field. It is eventually helpful to discuss past practice and improve candidate selectivity in a company decision making process.
Annexin A2 Enhances Complement Activation by Inhibiting Factor H
Authors: Renner Brandon , Tong Hua Hua , Laskowski Jennifer , Jonscher Karen , Goetz Lindsey , Woolaver Rachel , Hannan Jonathan , Li Yong Xing , Hourcade Dennis , Pickering Matthew C. , Holers V. Michael , Thurman Joshua M. 
Published: January 2016

Abstract
Factor H is a circulating protein that regulates activation of the alternative pathway (AP) of complement. Mutations and genetic variations of factor H are associated with several AP-mediated diseases, highlighting the critical role of factor H in AP regulation. AP-mediated inflammation is typically triggered by illness or tissue injury, however, and tissue injury can trigger AP activation in individuals with fully functional factor H. This suggests that factor H function is affected by local conditions within tissues. We hypothesized that inducible proteins impair the ability of factor H to locally control the AP, thereby increasing AP activation. We used purified murine factor H to immunoprecipitate binding partners from mouse kidneys. Using immunoaffinity liquid chromatography–mass spectrometry, we identified annexin A2 as a factor H binding partner. Further experiments showed that annexin A2 reduces the binding of factor H to cell surfaces. Recombinant annexin A2 impaired complement regulation by factor H and increased complement activation on renal cell surfaces in vitro and in vivo. In a murine model of acute pneumococcal otitis media, the administration of annexin A2 increased AP-mediated bacterial opsonization and clearance. In conclusion, the local production of annexin A2 within tissues suppresses regulation of the AP by factor H. Annexin A2 can contribute to AP-mediated tissue inflammation by locally impairing factor H function, but it can also improve complement-mediated bacterial clearance.
Dietary Vitamin D3 Suppresses Pulmonary Immunopathology Associated with Late-Stage Tuberculosis in C3HeB/FeJ Mice
Authors: Reeme Allison E. , Robinson Richard T. 
Published: January 2016

Abstract
Tuberculosis (TB) is a significant human disease caused by inhalation of Mycobacterium tuberculosis. Left untreated, TB mortality is associated with a failure to resolve pulmonary immunopathology. There is currently widespread interest in using vitamin D3 (VitD3) as an adjunct therapy for TB because numerous in vitro studies have shown that VitD3 has direct and indirect mycobactericidal activities. However, to date, there have been no in vivo studies addressing whether VitD3 affects experimental TB outcome. In this study, we used C3HeB/FeJ mice to determine whether dietary VitD3 influences the outcome of experimental TB. We observed that although M. tuberculosis burdens did not differ between mice on a VitD3-replete diet (VitDHI mice) and mice on a VitD3-deficient diet (VitDLO mice), the inflammatory response in VitDHI mice was significantly attenuated relative to VitDLO controls. Specifically, the expression of multiple inflammatory pathways was reduced in the lungs at later disease stages as were splenocyte IL12/23p40 and IFN-γ levels following ex vivo restimulation. Dietary VitD3 also suppressed the accumulation of T cells in the mediastinal lymph nodes and lung granulomatous regions while concomitantly accelerating the accumulation of F4/80+ and Ly6C/Ly6G+ lineages. The altered inflammatory profile of VitDHI mice also associated with reductions in pulmonary immunopathology. VitD receptor–deficient (vdr−/−) radiation bone marrow chimeras demonstrate that reductions in pulmonary TB immunopathology are dependent on hematopoietic VitD responsiveness. Collectively, our data support a model wherein the in vivo role of VitD3 during TB is not to promote M. tuberculosis killing but rather to function through hematopoietic cells to reduce M. tuberculosis–elicited immunopathology.
PSM Peptides of Staphylococcus aureus Activate the p38–CREB Pathway in Dendritic Cells, Thereby Modulating Cytokine Production and T Cell Priming
Authors: Armbruster Nicole S. , Richardson Jennifer R. , Schreiner Jens , Klenk Juliane , Günter Manina , Kretschmer Dorothee , Pöschel Simone , Schenke-Layland Katja , Kalbacher Hubert , Clark Kristopher , Autenrieth Stella E. 
Published: January 2016

Abstract
The challenging human pathogen Staphylococcus aureus has highly efficient immune evasion strategies for causing a wide range of diseases, from skin and soft tissue to life-threatening infections. Phenol-soluble modulin (PSM) peptides are major pathogenicity factors of community-associated methicillin-resistant S. aureus strains. In previous work, we demonstrated that PSMs in combination with TLR2 ligand from S. aureus induce tolerogenic dendritic cells (DCs) characterized by the production of high amounts of IL-10, but no proinflammatory cytokines. This in turn promotes the activation of regulatory T cells while impairing Th1 response; however, the signaling pathways modulated by PSMs remain elusive. In this study, we analyzed the effects of PSMs on signaling pathway modulation downstream of TLR2. TLR2 stimulation in combination with PSMα3 led to increased and prolonged phosphorylation of NF-κB, ERK, p38, and CREB in mouse bone marrow–derived DCs compared with single TLR2 activation. Furthermore, inhibition of p38 and downstream MSK1 prevented IL-10 production, which in turn reduced the capacity of DCs to activate regulatory T cells. Interestingly, the modulation of the signaling pathways by PSMs was independent of the known receptor for PSMs, as shown by experiments with DCs lacking the formyl peptide receptor 2. Instead, PSMs penetrate the cell membrane most likely by transient pore formation. Moreover, colocalization of PSMs and p38 was observed near the plasma membrane in the cytosol, indicating a direct interaction. Thus, PSMs from S. aureus directly modulate the signaling pathway p38–CREB in DCs, thereby impairing cytokine production and in consequence T cell priming to increase the tolerance toward the pathogen.
Evaluation of factors associated with relapse in telaprevir-based triple therapy for chronic hepatitis C
Authors: Kondo C , Atsukawa M , Tsubota A , Shimada N , Abe H , Aizawa Y 
Published: January 2016

Background and Rationale:
Most patients with chronic hepatitis C show virological response to telaprevir-based triple therapy, and achieve an end-of-treatment response (ETR). However, some patients showing ETR develop virological relapse. This study was carried out to evaluate factors associated with relapse after triple therapy.

Materials and Methods:
A prospective, multicentric study was conducted in chronic hepatitis C patients who received telaprevir-based triple therapy. We evaluated independent variables such as age, with or without cirrhosis, prior treatment response to interferon (IFN) therapy, IL28B genotype, core amino acid (aa) 70 mutation, drug adherence, white blood cell counts, hemoglobin level, and serum low-density lipoprotein (LDL) cholesterol level. The characteristics of the patients who relapsed after achieving ETR were compared with those who did not.

Results:
Among 168 patients, 157 patients achieved ETR (93.5%) and 11 discontinued. Of these 157 patients, relapse occurred in 21 patients (13.4%). Nineteen patients (90.5%) of 21 relapsed patients had the IL28B non-TT genotype (P = 1.79 × 10 -9). Multivariate analysis identified core amino acid 70 [P = 0.018, crude odds ratio (OR): 6.927] and the IL28B genotype (P = 3.758 × 10 -5, crude OR: 39.311) as significantly independent factors that influenced the relapse-related variables. Among the 49 patients with the IL28B non-TT, 18 patients had core aa70 mutation and 31 patients had core aa70 wild-type. In addition, 66.7% (12/18) of those with core aa70 mutation and 22.6% (7/31) of those with core aa70 wild-type developed relapse (P = 0.005).

Discussion:
Core aa70 mutation and the IL28B non-TT genotype were identified as independent factors that influenced relapse after achievement of ETR for telaprevir-based triple therapy.
Demographic and histopathologic profile of pediatric brain tumors: A hospital-based study
Authors: Shah Harshil C. , Ubhale Bhushan P. , Shah Jaimin K. 
Published: January 2016

Abstract
Background: Very few hospital-based or population-based studies are published in the context to the epidemiologic profile of pediatric brain tumors (PBTs) in India and Indian subcontinent. Aim: To study the demographic and histopathologic profile of PBTs according to World Health Organization 2007 classification in a single tertiary health care center in India. Materials and Methods: Data regarding age, gender, topography, and histopathology of 76 pediatric patients (0–19 years) with brain tumors operated over a period of 24 months (January-2012 to December-2013) was collected retrospectively and analyzed using EpiInfo 7. Chi-square test and test of proportions (Z-test) were used wherever necessary. Results: PBTs were more common in males (55.3%) as compared to females (44.7%) with male to female ratio of 1.23:1. Mean age was 10.69 years. Frequency of tumors was higher in childhood age group (65.8%) when compared to adolescent age group (34.2%). The most common anatomical site was cerebellum (39.5%), followed by hemispheres (22.4%). Supratentorial tumors (52.6%) were predominant than infratentorial tumors (47.4%). Astrocytomas (40.8%) and embryonal tumors (29.0%) were the most common histological types almost contributing more than 2/3rd of all tumors. Craniopharyngiomas (11.8%) and ependymomas (6.6%) were the third and fourth most common tumors, respectively. Conclusion: Astrocytomas and medulloblastomas are the most common tumors among children and adolescents in our region, which needs special attention from the neurosurgical department of our institute. Demographic and histopathologic profile of cohort in the present study do not differ substantially from that found in other hospital-based and population-based studies except for slight higher frequency of craniopharyngiomas.
Prospective randomized trial to compare the outcome and tolerability of delivering the same total dose of radiation in 61/2 weeks versus 51/2 weeks time in head and neck cancers
Authors: Gupta Manoj , Vats Siddharth , Bhattacharyya Tapesh , Seem Rajeev K. , Gupta Manish , Mahajan Rohit 
Published: January 2016

Abstract
Background: Concurrent chemoradiation is currently considered to be the standard of care in the treatment of head and neck cancer. In developing countries like ours, a good number of patients cannot tolerate chemoradiation because of the poor general condition and financial constraints. Those patients are treated with radiation alone. The optimum radiotherapy (RT) schedule for best local control and acceptable toxicity is not yet clear. We aimed to find out whether shortening of treatment time using six instead of five RT fractions per week improves the locoregional control in squamous cell carcinoma of head and neck. Materials and Methods: We conducted a prospective randomized study for a period of 2 years from September 2007 to August 2009 in 109 untreated patients of squamous cell carcinoma of head and neck with histologically confirmed diagnosis and no evidence of distant metastasis. Study group (55 patients) received accelerated RT with 6 fractions per week (66 Gy/33#/51/2 weeks). Control group (54 patients) received conventional RT with 5 fractions per week (66 Gy/33#/61/2 weeks). Tumor control, survival, acute and late toxicities were assessed. Results: At a median follow-up of 43 months, 29 patients (52.7%) in the 6 fractions group and 24 patients (44.4%) in the 5 fractions group were disease-free (P = 0.852). The benefit of shortening was higher for advanced disease control though it was not statistically significant. Grade 3 and 4 skin toxicity was significantly higher in the accelerated RT (70.9%) arm as compared to conventional (35.1%) arm (P = 0.04). Grade 3 mucositis was significantly higher in the accelerated RT arm (32.7% vs. 16.6%; P = 0.041). Those acute toxicities were managed conservatively. There was no difference in late toxicities between the two arms. Conclusion: Use of 6 fractions per week instead of 5 fractions per week is feasible, tolerable, and results in a better outcome in the patients of head and neck cancers.
Minimal invasive gastric surgery: A systematic review
Authors: Bushan Kirti , Sharma Sanjay , Attarde Niket 
Published: January 2016

Abstract
Background: As an alternate to open surgery, laparoscopic gastrectomy (LG) is currently being performed in many centers, and has gained a wide clinical acceptance. The aim of this review article is to compare oncologic adequacy and safety of LG with open surgery for gastric adenocarcinomas with respect to lymphadenectomy, short-term outcomes (postoperative morbidity and mortality) and long-term outcome (5 years overall survival and disease-free survival). Materials and Methods: PubMed was searched using query “LG” for literature published in English from January 2000 to April 2014. A total of 875 entries were retrieved. These articles were screened and 59 manuscripts ultimately formed the basis of current review. Results: There is high-quality evidence to support short-term efficacy, safety and feasibility of LG for gastric adenocarcinomas, although accounts on long-term survivals are still infrequent.
Prevalence of oral potentially malignant disorders in workers of Udupi taluk
Authors: Kumar Yeturu Sravan , Acharya Shashidhar , Pentapati Kalyana Chakravarthy 
Published: January 2016

Abstract
Objective: The objective was to assess the prevalence and risk factors of oral potentially malignant disorders (PMD) among industrial workers of Udupi taluk, Karnataka. Materials and Methods: The sample consisted of industrial workers aged >18 years from randomly selected industries in Udupi Taluk. A self-administered questionnaire was given to the participants to assess sociodemographic factors and abusive habits (Tobacco, Alcohol, and Betel quid) followed by clinical oral examination by single trained and calibrated examiner. Results: A total of 396 completed all steps of the survey and were included for analysis. A total of 14, 11.4, and 14.4% were tobacco, alcohol, and betel quid users, respectively. A total of 8.6% (n = 34) have at least one PMD. A significantly higher number of participants with single (11.4%) or combined habits (60.4%) had oral lesions while none of the participants without habits reported any oral lesions (P < 0.001). Conclusion: Prevalence of abusive habits and oral premalignant lesions or conditions was substantial among the workers. The cause and effect relationship and dose-response were also shown to be significantly associated. Prevention and early diagnosis through workplace screening are the major cornerstones for the control of oral cancer.