bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evidence for the potential role of m6A modification in regulating autophagy in models of amyotrophic lateral sclerosis
Authors: An Di , Han Jingzhe , Fang Pingping , Bu Yi , Ji Guang , Liu Mingjuan , Deng Jinliang , Song Xueqin 
Published: September 2024

Objective:
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. Research indicates that N6-methyladenosine (m6A) modification plays a crucial role in cellular autophagy during ALS development. This study investigates the role of autophagy in ALS, with a focus on the effect of messenger ribonucleic acid m6A methylation modification on disease progression.

Material and Methods:
We compared m6A levels and regulatory molecule expressions in transgenic superoxide dismutase (SOD1)-G93A and non-transgenic mice, categorized into end-stage and control groups, using quantitative polymerase chain reaction and Western blotting. The NSC-34 cell line, which was modified to model ALS, enabled the investigation of apoptosis, autophagy, and autophagy disruption through terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling assays, Western blotting, and fluorescent staining.

Results:
Our findings indicate significantly elevated m6A methylation levels in ALS mice (0.262 ± 0.005) compared with the controls (0.231 ± 0.003) and in the ALS model cells (0.242±0.005) relative to those belonging to the wild-type control group (0.183 ± 0.007). Furthermore, the proteins involved in m6A RNA modification differed between groups, which suggest impaired autophagy flux in the ALS models.

Conclusion:
These results suggest that m6A methylation may accelerate ALS progression through the disruption of autophagic processes. Our study underscores the role of m6A methylation in the pathology of ALS and proposes the targeting of m6A methylation as a potential therapeutic strategy for disease treatment. Although this study primarily used transgenic SOD1-G93A mice and NSC-34 cell models to investigate ALS pathology, potential differences in disease mechanisms between animal models and humans must be considered. Although a correlation was detected between m6A methylation levels and autophagy disruption in ALS, the study primarily established an association rather than provided detailed mechanistic insights.
IMPLEMENTASI KURIKULUM MERDEKA BELAJAR PADA PEMBELAJARAN BAHASA INDONESIA DALAM MENGEMBANGKAN KREATIVITAS PESERTA DIDIK DI SMK BAITURRAHIM KOTA JAMBI
Authors: Maulita Hasibuan Riska 
Published: September 2024

Tujuan penelitian ini ialah untuk melihat dan mendeskripsikan dan menganalisis implementasi kurikulum merdeka pada pembelajaran bahasa Indonesia dalam mengembangkan kreativitas peserta didik SMK Baiturrahim Kota Jambi. Selain itu, penelitian ini juga ditujukan untuk melihat dampak penerapan kurikulum merdeka pada pembelajaran bahasa Indonesia dalam mengembangkan kreativitas peserta didik. Penelitian ini menggunakan metode penelitian deskriptif kualitatif. Pendekatan dan jenis penelitian ini diambil dengan alasan untuk mendeskripsikan secara detail akan implementasi kurikulum merdeka pada pembelajaran bahasa Indonesia dalam mengembangkan kreativitas peserta didik SMK Baiturrahim Kota Jambi. Hasil penelitian ini menunjukkan bahwa pelaksanaan proses pembelajaran Penerapan kurikulum merdeka dalam pembelajaran bahasa Indonesia di SMK Baiturrahim telah dilaksanakan dengan baik. Dengan penerapan kurikulum baru yaitu kurikulum merdeka, telah menghasilkan transformasi positif dalam pengembangan kreativitas belajar siswa pada pembelajaran bahasa Indonesia di SMK Baiturrahim Kota Jambi. Pengembangan kreativitas pada peserta didik sendiri terlihat dari 4 konsep kreativitas yang muncul pada diri siswa. Kurkulum merdeka menjadikan siswa dapat berpikir secara kritis, memiliki kepekaan emosi, menunjukkan pengembangan keterampilan atau bakat yang dimiliki, serta memiliki imajinasi yang kuat dalam pelaksanaan pembelajaran bahasa Indonesia dalam penerapan kurikulum merdeka. implementasi kurikulum merdeka telah berhasil diterapkan dengan baik di SMK Baiturrahim sekaligus terbukti dapat mengembangkan kreativitas siswa, seperti peserta didik dapat berpikir kritis dan rasional, peserta didik memiliki kepekaan emosi, peserta didik menemukan keterampilan atau bakat yang ada pada dirinya, dan ini juga dapat mendorong imajinasi yang kuat pada peserta didik. Adapun dampak dari penerapan kurikulum merdeka dalam proses pembelajaran dapat memudahkan eksplorasi keterampilan dan bakat siswa selama proses pembelajaran sehingga menghasilkan hasil belajar yang inventif dan orisinal.
Evaluation the Hematological Alterations in Females with Breast Cancer
Authors: Al-Maaroof Zainab W. , Al-khafaji Teeb M. Jaafar 
Published: September 2024

Background: Cross-sectional research conducted in Baghdad province, women with breast cancer, both young and elderly, were evaluated alongside healthy persons to determine certain hematological parameters. This study aimed for evaluation the Hematological alterations in females with breast cancer.
Materials and Methods: The investigation was conducted in private hospitals, forty women diagnosed with breast cancer and ten healthy controls were randomly sampled between 2020 and 2022. From each female patient and control , three milliliters of venous blood were given, which was then dispensed into an EDTA container, in order to evaluate the hematological parameters. Additional analyses utilizing the (Auto Hematology Analyzer) were carried out on the EDTA samples, including PCV, WBC, RBC, platelet count, and lymphocyte count. Procedures followed in the handbook for the testing. Using the conventional Westergren technique, the ESR was calculated.
Results: The current results showed that there was a significant difference between the examined population and the control group in terms of mean RBC, PCV, platelets count, WBC, and lymphocytes, with a p-value of less than 0.05. In contrast, the control participants had considerably lower mean ESR levels (p < 0.05) compared to the breast cancer patients.
Conclusion: breast cancer can affect all blood components including RBC, WBC, platelets and its related parameters.
Efektivitas Ifdil perceptual light technique untuk mengurangi social anxiety siswa obesitas
Authors: Arrahman Iqbal , Ifdil Ifdil , Karneli Yeni , Fadli Rima Pratiwi , Khairati Annisaislami 
Published: September 2024

Obesitas pada remaja sering dikaitkan dengan permasalah psikologis, seperti stres, anxiety, depresi bahkan trauma dan PTSD. Obesitas dapat menjadi salah satu faktor yang beresiko bagi perkembangan social anxiety siswa. Social anxiety merupakan salah satu jenis gangguan kecemasan yang bersifat khusus. Pada gangguan ini penderitanya akan merasakan kekhawatiran yang berlebihan ketika berada di sekitar orang banyak. Beberapa gejala fisik yang dapat diamati adalah munculnya keringat dan gemetar saat berinteraksi dengan orang banyak. Sehingga siswa dengan gangguan ini cenderung untuk menghindari pertemuan dan kegiatan yang melibatkan orang lain. Oleh karena itu penting bagi siswa yang mengalami obesitas untuk mendapatkan bantuan psikologis yang sesuai. Salah satu bantuan yang dapat diberikan adalah dengan menggunakan teknik Ifdil Perceptual Light Technique (IPLT). Teknik IPLT merupakan sebuah alternatif pendekatan brief untuk mereduksi berbagai macam permasalahan psikologis, salah satunya kecemasan. Intervensi menggunakan IPLT dilakukan melalui modifikasi sensorik dan persepsi individu melalui spektrum cahaya. IPLT menggunakan kombinasi teknologi, bahasa pemrograman, dan beberapa pendekatan sebelumnya, yang bertujuan untuk mengurangi stes, kecemasan, trauma, fobia dan gangguan psikologis lainnya dalam waktu yang relatif singkat yaitu kurang dari sepuluh menit Penelitian ini bertujuan untuk menguji IPLT dalam mengurangi social anxiety siswa obesitas. Penelitian ini menggunakan desain subjek tunggal terhadap satu subjek yang mengalami soial anxiety.Desain penelitian menggunakan desain A-B single subject penelitian. Instrumen yang digunakan adalah observasi, wawancara, teknik scaling dan menggunakan instrumen social anxiety. Hasil penelitian menunjukkan bahwa responden memiliki tingkat social anxiety tinggi sebelum intervensi. Namun setelah diberikan intervensi melalui IPLT tingkat social anxiety menurun. Hasilnya menunjukkan bahwa IPLT efektif untuk mengurangi social anxiety pada siswa obesitas.
Towards a Mexican School of General Analytical Chemistry
Authors: Rojas-Hernández Alberto , Ramírez-Silva María Teresa , Galano Annia 
Published: September 2024

This year the 50th anniversary of the Metropolitan Autonomous University is celebrated. It is for this reason that the JMCS decided to publish a special issue with contributions from professors from the Department of Chemistry. We thank the Editorial Committee of the issue for the invitation to write an article about the academic work that has been done in the Analytical Chemistry Area of this Department. We hope that we have managed to give a good description of the achievements we have had since the Analytical Chemistry Area was founded in the Iztapalapa Unit of the Metropolitan Autonomous University.

Resumen. En este año se celebra el 50 aniversario de la Universidad Autónoma Metropolitana. Es con ese motivo que el JMCS decidió publicar un número especial con contribuciones de profesores del Departamento de Química. Agradecemos al Comité Editorial del número la invitación para hacer una contribución acerca del trabajo académico que se ha hecho en el Área de Química Analítica. Esperamos que hayamos logrado dar una buena descripción de los logros que hemos tenido desde que se fundó el Área de Química Analítica en la Unidad Iztapalapa de la Universidad Autónoma Metropolitana.
Cytokine imbalance as a factor of postoperative complications of third mandibular molar extraction
Authors: Glushkova M. I. , Seminskiy I. Zh. , Alyoshkin I. G. 
Published: September 2024

Background. Tooth extraction is considered the most frequently performed operation in surgical dentistry, which can often cause inflammatory complications. Modern research has come a long way in terms of developing methods for the prevention, diagnosis and treatment of these complications, but the search for their early laboratory markers remains an urgent task to this day.The aim of the study. To determine prognostic laboratory criteria for the development of local inflammatory complications of third mandibular molar extraction.Methods. The study included 35 people who underwent extraction of a third mandibular (semi-impacted) molar. Before the surgery, immediately after the surgery, 1, 2, 3 and 4 days after the surgery, we assessed the objective status of the patients and collected oral fluid from the oral cavity, in which we determined the concentrations of cytokines using enzyme-linked immunosorbent assay. After the surgery, patients were divided into a control group and a group with complications with determination of their cytokine status.Results. Immediately after the surgery, patients from the group with complications, compared with patients from the control group, had significantly higher levels of proinflammatory cytokines – interleukin (IL) 1, IL-8 and comparable levels of tumor necrosis factor α and anti-inflammatory cytokines IL-4 and IL-10. Integral cytokine indices in both groups showed a sharp shift towards pro-inflammatory direction in patients with complications. This fact determines the protracted or progressive nature of the inflammatory process after the surgery.Conclusion. Determining the level of individual cytokines and cytokine indices in the oral fluid after the extraction of a third mandibular molar allows us to identify early markers for the chronicity of the inflammatory process, to predict its further course and to take appropriate measures to prevent the development of expected complications.
Current ideas on the pathogenesis of osteoporosis in chronic lymphatic leukemia (literature review)
Authors: Osikov M. V. , Korobkin E. A. , Fedosov A. A. , Sineglazova A. V. 
Published: September 2024

Background. Chronic lymphocytic leukemia (CLL) is the second most common hematological malignancy without a trend towards a decrease in its incidence. 66 % of patients with CLL experience bone fractures as a result of osteoporosis in all age groups, and the detection frequency is no more than 15 %. Insufficient understanding of the osteoporosis pathogenesis in CLL leads to problems in diagnosis, prevention and therapy.The aim of the study. To analyze modern data on the features of the osteoporosis pathogenesis in chronic lymphocytic leukemia.Results and discussion. Osteoporosis is formed when osteoresorption prevails over osteosynthesis due to intercellular interactions of bone tissue and the immune system, dysregulation of intracellular signaling pathways RANKL/RANK/OPG, Wnt, FoxO, RUNX2, initiated by cytokines, growth factors, prostaglandins, and hormones. The degree of osteoresorption in CLL is associated with the severity of the clinical course, chemotherapy and hormonal deprivation. The osteoporosis pathogenesis in CLL is considered as part of a complex set of events, including, firstly, the interaction between leukemic cells (overexpression of PTHrP, RANKL) and bone cells (synthesis of growth factors), which forms a vicious circle of osteoresorption and tumor growth. Secondly, pro-inflammatory markers in CLL (tumor necrosis factor α, interleukin (IL) 1β, IL-6, IL-8, IL-11, granulocyte-macrophage colony-stimulating factor, macrophage colony-stimulating factor, transforming growth factor β, prostaglandin E2) limit osteoblast-induced osteosynthesis and stimulate the expansion of osteoclasts from monocytic suppressor cells of myeloid origin with or without the participation of the RANKL/RANK system. Thirdly, oxidative stress in CLL and impaired efficiency of antioxidant protection with the participation of fibroblast growth factor 23, transcription factor Nrf-2 with activation of JNK, ERK1/2, NF-κB, and also an increase in the RANKL/OPG ratio lead to inhibition of osteoblastogenesis.Conclusion. Analyzing and systematizing data on the osteoporosis pathogenesis in CLL are instrumental for the development of diagnostic criteria for osteoporosis in chronic lymphocytic leukemia that are much-needed in clinical practice and for the improvement of therapeutic tactics.
Correction of professional burnout of health workers in the process of mindfulness-based training
Authors: Popova K. M. , Kuzmin M. Yu. 
Published: September 2024

Background. The article reviews the problem of testing the in-person version of the burnout reduction program "OsNOVA" for health workers.The aim of the work. To present the results of the program immediately after its completion and to study the sustainability of the effect.Materials and methods. As part of the program testing, 49 doctors and nurses were interviewed. The following methods were used: Maslach Burnout Inventory; Lazarus and Folkman Inventory of Coping Strategies; Beck Depression Inventory; Perceived Stress Scale 10; Short Form 12 questionnaire; mindfulness questionnaires.Results. It was found that when implementing a program to reduce the level of professional burnout in medical workers, held in-person, there is a statistically significant decrease in those subjects whose burnout was initially high. This is accompanied by an increase in mindfulness (primarily such components as Non-judgmentalism, Observation and Awareness of Actions), productive coping strategies. Health workers with a relatively low level of burnout had an improvement in a number of indicators reflecting the burnout level, as well as an increase in the quality of life. The effect achieved by the program persisted for at least three months after the end of its active part.Conclusion. The "OsNOVA" program in an in-person format can be used to prevent professional burnout of health workers. Additional work is planned for its further improvement.
Oscillation Criteria For Solution Of The Fourth Order Nonlinear Neutral Differential Equations
Authors: Ali Hassan Ali Hassan Mohammed , Goodi Raheem Doaa 
Published: September 2024

In this research , we study the properties of oscillation for all neutral differential equations Its importance in solving many engineering, physical and chemical problems and giving better results in a timely manner within a specific period of time some basic necessary and sufficient condition are established for every solution of solutions of the fourth order nonlinear
To become oscillatory , Examples are given insupport our results
A New Hybrid Conjugate Gradient Method with Global Convergence Properties
Authors: F. Aziz Rahma , Younis Maha S. 
Published: September 2024

This work introduces a novel hybrid conjugate gradient (CG) technique for tackling unconstrained optimisation problems with improved efficiency and effectiveness. The parameter is computed as a convex combination of the standard conjugate gradient techniques using and . Our proposed method has shown that when using the strong Wolfe-line-search (SWC) under specific conditions, it achieves global theoretical convergence. In addition, the new hybrid CG approach has the ability to generate a search direction that moves downward with each iteration. The quantitative findings obtained by applying the recommended technique about 30 functions with varying dimensions clearly illustrate its effectiveness and potential. This work introduces a novel hybrid conjugate gradient (CG) technique for tackling unconstrained optimisation problems with improved efficiency and effectiveness. The parameter is computed as a convex combination of the standard conjugate gradient techniques using and . Our proposed method has shown that when using the strong Wolfe-line-search (SWC) under specific conditions, it achieves global theoretical convergence. In addition, the new hybrid CG approach has the ability to generate a search direction that moves downward with each iteration. The quantitative findings obtained by applying the recommended technique about 30 functions with varying dimensions clearly illustrate its effectiveness and potential.
Effect of Trichoderma harzianum in the Protection of Wheat Grains from Infestation with Rhyzopertha dominica (Fab) During the Store
Authors: Mahmood Sarah 
Published: September 2024

Abstract:
Currently, the economic losses generated by the attack of pests on the storages constitute a severe problem. Conventional grain protection methods based on the application of chemical pesticides to control these undesirable insects have also formed to represent an annoyance since the excessive usage of these compounds is linked to contamination problems and serious harm to consumers' health. This research aims to possibility of creating a means to protect the grain stores from infestation with Rhyzopertha dominica through testing for the efficiency of Trichoderma harzianum with three concentrations (7x104, 7x106, 7x108 and spores /ml) in the protection of grains in jute sacks from infection by this pest after three months of storage period and the effect of T. harzianumon . The results showed that the high efficiency of T. harzianumon in protecting the grain stores from infestation by these insect sacks was measured when treated in the bags with the highest concentration of 7x108 spores/ml of fungi, and the total weight loss was 2.0269. while the control treatment gave 6.4012-gram weight losses. also shows the total weight loss was 4.054 when the grains were treated with the highest concentration of 7x108 spores/ml of fungus. in contrast to 8.0629-gram weight decreases with the control treatment. and treated the bags and grains with 7x108 spores/ml of fungi, the total percentage of weight losses was 1.7033 after three months from storage. while the control treatment gave 11.475 grams of weight loss.
Elimination of phenol by sonoelctrochemical process utilizing graphite, stainless steel, and titanium anodes: optimization by taguchi approach
Authors: Nsaif Hind Jabbar , Majeed Najwa Saber , Salman Rasha H. , Abed Khalid M. 
Published: September 2024

Phenol is one of the worst-damaging organic pollutants, and it produces a variety of very poisonous organic intermediates, thus it is important to find efficient ways to eliminate it. One of the promising techniques is sonoelectrochemical processing. However, the type of electrodes, removal efficiency, and process cost are the biggest challenges. The main goal of the present study is to investigate the removal of phenol by a sonoelectrochemical process with different anodes, such as graphite, stainless steel, and titanium. The best anode performance was optimized by using the Taguchi approach with an L16 orthogonal array. the degradation of phenol sonoelectrochemically was investigated with three process parameters: current density (CD) (25, 50, 75, and 100 mA/cm2), time (1, 2, 3, 4 h), and phenol concentration (100, and 200 mg/l). Signal-to-noise (S/N) ratio and analysis of variance (ANOVA) were utilized to examine the impact of each factor. The optimal conditions for phenol removal were 100 mA/cm2, 100 mg/l of phenol, and 4 hours of electrolysis. Under optimal operating conditions, the phenol removal efficiency was 80.99%. The CD was the most influential factor on phenol elimination effectiveness, while the phenol concentration had the least impact.
Using well log data to predict rock compressibility and elasticity in Zubair formation/ southern of Iraq
Authors: Nather Hiba Alaa Al-Deeen , Abdul-Majeed Rwaida Kaiser , F. Mukhtar Yasir M. 
Published: September 2024

The mechanical characteristics of rocks such as elasticity (Young's modulus, Poisson's ratio, and unconfined compressive strength) play an essential in sand production analysis, well design, and borehole stability assessment. In this study, the mechanical characteristics of rocks were indirectly estimated using gamma ray, density, and acoustic (compressional and shear) log data from well RU-X in the Rumaila oil field, specifically for the Zubair Formation. These estimated properties were compared to direct measurements obtained from triaxial and uniaxial mechanical tests conducted on well RU-X. The results showed a significant similarity between the indirect estimates and the direct measurements, indicating their reliability for sand production analysis and their valuable contribution to constructing the geomechanical model. Moreover, the static profile of Poisson's ratio was validated using laboratory core test results, demonstrating reasonable agreement. The validation process involved comparing laboratory-derived measurements with actual field measurements in the Zubair Formation. The higher Poisson's ratio observed in the shale was attributed to the slower propagation of acoustic waves, resulting in a good matching with an R2 value of 0.77. On the other hand, the lower Young's modulus in the shaly formations indicated lower resistance to deformation, with a comparative ratio of R²=0.96. Static measurements, which consider various influencing factors, provide a more realistic representation of rock behavior under different conditions. Regarding unconfined compressive strength, the comparative ratio was R²=0.83.