bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proximal duodenoileal anastomosis for treatment of small intestinal obstruction and volvulus in a green iguana (Iguana iguana)
Authors: Wills Sarah , Beaufrère Hugues , Watrous Gwyneth , Oblak Michelle L. , Smith Dale A. 
Published: October 2016

Abstract
CASE DESCRIPTION A 13-year-old female green iguana (Iguana iguana) was examined because of a 6-day history of vomiting, anorexia, and lethargy and a 4-day history of decreased fecal and urate output.
CLINICAL FINDINGS Physical examination revealed a distended abdomen, signs of depression, pallor, tachycardia, harsh lung sounds, and vomiting. Abdominal radiographs revealed gas distention of the stomach and small intestine with fluid lines evident on the lateral view. Plasma biochemical analysis indicated hypochloremic metabolic alkalosis, hyperglycemia, and hyperuricemia.
TREATMENT AND OUTCOME Exploratory laparotomy confirmed a diagnosis of small intestinal entrapment and 170° volvulus involving approximately 80% (20 to 30 cm) of the small intestine. The portion of the small intestine extending from the middle portion of the duodenum to the caudal extent of the ileum was resected, and end-to-end anastomosis of the remaining small intestine was performed. The iguana recovered without apparent complications and was reportedly doing well 1 year after surgery.
CLINICAL RELEVANCE Findings suggested that iguanas, as hindgut fermenters, may tolerate > 70% resection of the small intestine with a good outcome and no clinical evidence of residual gastrointestinal dysfunction.
A randomized controlled trial of the effect of prednisone omission from a multidrug chemotherapy protocol on treatment outcome in dogs with peripheral nodal lymphomas
Authors: Childress Michael O. , Ramos-Vara José A. , Ruple Audrey 
Published: October 2016

Abstract
OBJECTIVE To determine the effect of prednisone omission from a multidrug chemotherapy protocol on outcome in dogs with peripheral nodal lymphomas.
DESIGN Single-center, nonblinded, parallel-group, randomized, controlled trial.
ANIMALS 40 client-owned dogs with a histopathologically confirmed diagnosis of peripheral nodal lymphoma and an expected survival time of > 4 weeks with treatment.
PROCEDURES Treatment consisted of a combination of L-asparaginase, cyclophosphamide, doxorubicin, vincristine, and prednisone (L-CHOP) or an identical protocol except for the omission of prednisone (L-CHO). The primary outcome of interest was progression-free survival time. Veterinary caregivers and assessors of outcome were not blinded to treatment assignment. Treatment assignment was concealed from the owners of study dogs prior to enrollment, but was revealed after written informed consent was provided.
RESULTS The trial was terminated early because of slow enrollment. The 40 dogs successfully enrolled in the study were randomly assigned to the L-CHOP (n = 18) or L-CHO (22) group; results for all 40 dogs were analyzed with respect to the primary outcome. Median progression-free survival time was 142.5 days for dogs receiving L-CHO and 292 days for dogs receiving L-CHOP (hazard ratio, 1.79; 95% confidence interval, 0.85 to 3.75). Serious adverse events were more common among dogs receiving L-CHO. However, this difference was not significant.
CONCLUSIONS AND CLINICAL RELEVANCE The exclusion of prednisone from the L-CHOP protocol did not appear to result in improved progression-free survival time for dogs with peripheral nodal lymphomas. However, the present trial was likely underpowered to detect a clinically meaningful difference in progression-free survival time between groups.
Maternal administration of meclozine for the treatment of foramen magnum stenosis in transgenic mice with achondroplasia
Authors: Matsushita Masaki , Mishima Kenichi , Esaki Ryusaku , Ishiguro Naoki , Ohno Kinji , Kitoh Hiroshi 
Published: October 2016

OBJECTIVE
Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. Foramen magnum stenosis (FMS) is one of the serious neurological complications in ACH. Through comprehensive drug screening, the authors identified that meclozine, an over-the-counter drug for motion sickness, inhibited activation of FGFR3 signaling. Oral administration of meclozine to the growing ACH mice promoted longitudinal bone growth, but it did not prevent FMS. In the current study, the authors evaluated the effects of maternal administration of meclozine on FMS in ACH mice.

METHODS
The area of the foramen magnum was measured in 17-day-old Fgfr3ach mice and wild-type mice using micro-CT scanning. Meclozine was administered to the pregnant mice carrying Fgfr3ach offspring from embryonic Day (ED) 14.5 to postnatal Day (PD) 4.5. Spheno-occipital and anterior intraoccipital synchondroses were histologically examined, and the bony bridges were scored on PD 4.5. In wild-type mice, tissue concentrations of meclozine in ED 17.5 fetuses and PD 6.5 pups were investigated.

RESULTS
The area of the foramen magnum was significantly smaller in 17-day-old Fgfr3ach mice than in wild-type mice (p < 0.005). There were no bony bridges in the spheno-occipital and anterior intraoccipital synchondroses in wild-type mice, while some of the synchondroses prematurely closed in untreated Fgfr3ach mice at PD 4.5. The average bony bridge score in the cranial base was 7.053 ± 1.393 in untreated Fgfr3ach mice and 6.125 ± 2.029 in meclozine-treated Fgfr3ach mice. The scores were not statistically significant between mice with and those without meclozine treatment (p = 0.12). The average tissue concentration of meclozine was significantly higher (508.88 ± 205.16 ng/g) in PD 6.5 mice than in ED 17.5 mice (56.91 ± 20.05 ng/g) (p < 0.005).

CONCLUSIONS
Maternal administration of meclozine postponed premature closure of synchondroses in some Fgfr3ach mice, but the effect on preventing bony bridge formation was not significant, probably due to low placental transmission of the drug. Meclozine is likely to exhibit a marginal effect on premature closure of synchondroses at the cranial base in ACH.
FLAIR signal increase of the fluid within the resection cavity after glioma surgery: generally valid as early recurrence marker?
Authors: Bette Stefanie , Gempt Jens , Huber Thomas , Delbridge Claire , Meyer Bernhard , Zimmer Claus , Kirschke Jan S. , Boeckh-Behrens Tobias 
Published: October 2016

OBJECTIVERecent studies have indicated that a signal intensity increase of the fluid within the resection cavity on FLAIR images may predict tumor recurrence after glioma surgery. The aim of this study was to assess the increase in FLAIR signal intensity in a large patient cohort and in subgroups to assess its prognostic value for early tumor recurrence in glioma patients.METHODSA total of 212 patients (213 cases) who had undergone surgery for an intracranial glioma (WHO Grade IV [n = 103], WHO Grade III [n = 57], and WHO Grade II [n = 53]) were included in this retrospective study. FLAIR signal within the resection cavity at the time of tumor recurrence/last contact and on the previous MRI study was assessed qualitatively and quantitatively. Appearance of FLAIR signal increase was studied over time using Kaplan-Meier estimates in subgroups.RESULTSPatients with WHO Grade II glioma and connection of the resection cavity to CSF who did not undergo radiotherapy did not regularly develop this sign and were excluded from further analysis. For the remaining 87 cases, FLAIR signal intensity increase was observed in 27 cases. Recurrent disease was found in 26 of these 27 cases, resulting in a specificity of 80.0%, a sensitivity of 31.7%, and positive and negative predictive values of 96.3% and 6.7%, respectively. In 4 cases this sign had been observed prior (range 2.8–8.5 months) to tumor recurrence defined by standard criteria. Quantitative analysis underlined the results of qualitative analysis, but it did not add a diagnostic value.CONCLUSIONSSignal intensity increase of the fluid within the resection cavity on FLAIR images is a rare but highly specific and early sign for tumor recurrence/tumor progression in completely and incompletely resected high-grade glioma without connection of the resection cavity to CSF and with radiotherapy.
Postoperative urinary retention in patients undergoing elective spinal surgery
Authors: Altschul David , Kobets Andrew , Nakhla Jonathan , Jada Ajit , Nasser Rani , Kinon Merritt D. , Yassari Reza , Houten John 
Published: October 2016

OBJECTIVE
Postoperative urinary retention (POUR) is a common problem leading to morbidity and an increased hospital stay. There are limited data regarding its baseline incidence in patients undergoing spinal surgery and the risk factors with which it may be associated. The purpose of this study was to evaluate the incidence of POUR in elective spine surgery patients and determine the factors associated with its occurrence.

METHODS
The authors retrospectively reviewed the records of patients who had undergone elective spine surgery and had been prospectively monitored for POUR during an 18-month period. Collected data included operative positioning, surgery duration, volume of intraoperative fluid, length of hospital stay, and patient characteristics such as age, sex, and medical comorbidities. Dialysis patients or those with complete urinary retention preoperatively were excluded from analysis.

RESULTS
Of the 397 patients meeting the study inclusion criteria, 35 (8.8%) developed POUR. An increased incidence of POUR was noted in those who underwent posterior lumbar surgery, those with benign prostatic hypertrophy (BPH), those with chronic constipation or prior urinary retention, and those using a patient-controlled analgesia pump postoperatively. An increased incidence of POUR was seen with a longer operative time but not with intraoperative intravenous fluid administration. A significant relationship between the female sex and POUR was noted after controlling for BPH, yet there was no association between POUR and diabetes or intraoperative instrumentation. Postoperative retention significantly prolonged the hospital stay. Three patients developed epidural hematomas necessitating operative reexploration, and while they experienced POUR, they also developed the full constellation of cauda equina syndrome.

CONCLUSIONS
Awareness of the risk factors for POUR may be useful in perioperative Foley catheter management and in identifying patients who need particular vigilance when they are due to void postprocedure. A greater understanding of POUR may also prevent longer hospital stays in select at-risk patients. Postoperative retention is rarely caused by a postoperative cauda equina syndrome due to epidural hematoma, which is also associated with saddle anesthesia, leg pain, and weakness, yet the delineation of isolated POUR from this urgent complication is necessary for optimal patient care.
Application of low concentration contrast medium in spectral CT imaging for CT portal venography
Authors: Zhao Yongxia , Wu Yanmin , Zuo Ziwei , Suo Hongna , Zhao Sisi , Han Jun , Chang Xian , Cheng Shujie 
Published: October 2016

OBJECTIVE: To investigate the effect of low-concentration contrast medium on spectral computed tomography (CT) image quality for portal venography CT. METHODS: 150 patients with suspected portal diseases were divided into three groups and had spectral CT examination using a GE Discovery CT 750 HD scanner. The patients in three groups were injected with different concentrations of iodine (350 mgI/mL, 315 mgI/mL and 280 mgI/mL) at an injection rate of 4.0–5.0 mL/s with 1.2 mL/kg (body weight) of contrast medium, respectively. During the portal vein imaging phase, 0.625 mm-slice-thickness monochromatic images and optimal monochromatic images were obtained. Optimal keV mono-energy was achieved using the optimal contrast-to-noise ratio (CNR) in the portal vein relative to the erector spinae muscle. Volume rendering and maximum intensity projection methods were applied to generate portal venography. The CT values and standard deviations were measured at the portal vein, the erector spinae muscle, and the abdomen fat, respectively. These values were used to calculate the signal-to-noise ratio (SNR); while CNR was calculated using CT values of the portal vein and erector spinae muscle. The overall imaging quality was evaluated on a five-point scale by two radiologists with at least five years’ experience. Comparisons among the three groups were performed using One-Way ANOVA test. RESULTS: Monochromatic images at 50–53 keV demonstrated the best CNR for both the portal vein and erector spinae muscle. SNR and CNR of images with different contrast medium concentrations were similar ( P > 0.05). The five-point scores were also similar ( P > 0.05) for the three groups. The total iodine intake at 280 mgI/mL was 25.4% lower than that at 350 mgI/mL. CONCLUSIONS: Spectral CT with monochromatic images at 50–53 keV allows significant reduction in iodine load while improving portal vein signal intensity and maintaining image quality.
TURBULENCE AND STAR FORMATION IN A SAMPLE OF SPIRAL GALAXIES
Authors: Maier Erin , Chien Li-Hsin , Hunter Deidre A. 
Published: October 2016

ABSTRACT
We investigate turbulent gas motions in spiral galaxies and their importance to star formation in far outer disks, where the column density is typically far below the critical value for spontaneous gravitational collapse. Following the methods of Burkhart et al. on the Small Magellanic Cloud, we use the third and fourth statistical moments, as indicators of structures caused by turbulence, to examine the neutral hydrogen (H i) column density of a sample of spiral galaxies selected from The H i Nearby Galaxy Survey. We apply the statistical moments in three different methods—the galaxy as a whole, divided into a function of radii and then into grids. We create individual grid maps of kurtosis for each galaxy. To investigate the relation between these moments and star formation, we compare these maps with their far-ultraviolet images taken by the Galaxy Evolution Explorer satellite.We find that the moments are largely uniform across the galaxies, in which the variation does not appear to trace any star-forming regions. This may, however, be due to the spatial resolution of our analysis, which could potentially limit the scale of turbulent motions that we are sensitive to greater than ∼700 pc. From comparison between the moments themselves, we find that the gas motions in our sampled galaxies are largely supersonic. This analysis also shows that the Burkhart et al. methods may be applied not just to dwarf galaxies but also to normal spiral galaxies.
Destins féminins entre mariage et maternité
Authors: Belmont Nicole 
Published: October 2016

Trois contes de tradition orale rapportant le passage des jeunes filles au mariage et à la maternité sont successivement présentés : « L’enfant de Marie », « La fille aux mains coupées » et « La fille innocente qui accouche d’un monstre ». Chacun d’eux s’attache à une entrave psychique concernant, pour le premier, la relation fusionnelle entre mère et fille, qui permet à cette dernière le mariage mais non la maternité ; le second, qui détaille les étapes de ce passage où la mutilation physique de la jeune fille l’amène au mariage et où la restauration du corps permet la maternité ; le troisième où la procréation orale magique élimine la personne du père et permet une relation fusionnelle entre le fils et la mère. Ces récits fournissent des images et des mises en scène qui traduisent remarquablement bien les phantasmes conscients parfois, mais surtout inconscients, des bouleversements subis par les filles au moment d’accéder au mariage.
Consistance et densification de l’identité féminine
Authors: Bataillon Nathalie 
Published: October 2016

La construction de l’identité féminine reste à développer, notamment sur trois aspects : le rapport des femmes à leur activité professionnelle, le développement de leur compréhension de l’inévitable tension entre maternel et féminin, et la construction de rapports hommes-femmes où la question de l’égalité est questionnée et travaillée.
The Role of Computed Tomography in Predicting Left Ventricular Assist Device Infectious Complications
Authors: Gomez Carrie K , Schiffman Scott R , Hobbs Susan K 
Published: October 2016

Objective:
The purpose of this study is to identify early computed tomography findings around the driveline which would predict mediastinal or left ventricular assist device (LVAD) pocket abscess formation.

Materials and Methods:
A retrospective analysis was performed on 128 LVAD recipients between January 2007 and December 2011. Infectious complications were subdivided into those affecting the driveline and those resulting in abscess formation either around the LVAD pump or mediastinum. The size and location of infiltrative changes surrounding the driveline were used to predict infection propagation resulting in abscess.

Results:
Of the 128 patients, 49 (38.3%) patients developed driveline infections and 24 (18.8%) patients developed abscess. 87.5% patients who developed abscess had a preceding driveline infection. The mean time from driveline infection to the development of pump pocket abscess was approximately 7 months. In addition, patients with abscess in the pump pocket or mediastinum had preceding infiltrative changes surrounding the driveline ≥14 mm (P = 0.0001). A preperitoneal location and size of infiltrative changes ≥14 mm were correlated with a higher likelihood of abscess formation (P = 0.0002).

Conclusion:
Our study demonstrates the predictive value of infection/infiltrative changes around the driveline, which increases the risk for abscess formation in the LVAD pump pocket and/or in the mediastinum.
Tubular Free by Cyclic Groups Act Freely on CAT(0) Cube Complexes
Authors: Button Jack 
Published: October 2016

AbstractWe identify when a tubular group (the fundamental group of a ûnite graph of groups with ℤ2vertex and ℤ edge groups) is free by cyclic and show, using Wise’s equitable sets criterion, that every tubular free by cyclic group acts freely on a CAT(0) cube complex.
Quantifying horizontal and vertical tracer mass fluxes in an idealized valley during daytime
Authors: Leukauf Daniel , Gohm Alexander , Rotach Mathias W. 
Published: October 2016

Abstract. The transport and mixing of pollution during the daytime evolution of a valley boundary layer is studied in an idealized way. The goal is to quantify horizontal and vertical tracer mass fluxes between four different valley volumes: the convective boundary layer, the slope wind layer, the stable core, and the atmosphere above the valley. For this purpose, large eddy simulations (LES) are conducted with the Weather Research and Forecasting (WRF) model for a quasi-two-dimensional valley. The valley geometry consists of two slopes with constant slope angle and is homogeneous in the along-valley direction. The surface sensible heat flux is horizontally homogeneous and prescribed by a sine function. The initial sounding is characterized by an atmosphere at rest and a constant Brunt–Väisälä frequency. Various experiments are conducted for different combinations of surface heating amplitudes and initial stability conditions. A passive tracer is released with an arbitrary but constant rate at the valley floor and resulting tracer mass fluxes are evaluated between the aforementioned volumes.As a result of the surface heating, a convective boundary layer is established in the lower part of the valley with a stable layer on top – the so-called stable core. The height of the slope wind layer, as well as the wind speed within, decreases with height due to the vertically increasing stability. Hence, the mass flux within the slope wind layer decreases with height as well. Due to mass continuity, this along-slope mass flux convergence leads to a partial redirection of the flow from the slope wind layer towards the valley centre and the formation of a horizontal intrusion above the convective boundary layer. This intrusion is associated with a transport of tracer mass from the slope wind layer towards the valley centre. A strong static stability and/or weak forcing lead to large tracer mass fluxes associated with this phenomenon. The total export of tracer mass out of the valley atmosphere increases with decreasing stability and increasing forcing. The effects of initial stability and forcing can be combined to a single parameter, the breakup parameter B. An analytical function is presented that describes the exponential decrease of the percentage of exported tracer mass with increasing B. This study is limited by the idealization of the terrain shape, stratification, and forcing, but quantifies transport processes for a large range of forcing amplitudes and atmospheric stability.
Head-Neck Taper Corrosion following Total Hip Arthroplasty with Stryker Meridian Stem
Authors: Patel Sonika , Talmo Carl T. , Nandi Sumon 
Published: October 2016

Background Taper corrosion at the modular junctions of total hip arthroplasty (THA) femoral stems are known to cause locally destructive adverse local tissue reaction (ALTR). However, the implants at risk remain to be fully elucidated. Case review We report the case of a 76-year-old woman with hip pain, abductor weakness, and sciatic nerve symptoms 2 years following metal-on-polyethylene THA. Serum cobalt levels were elevated, while chromium levels were normal. Magnetic resonance imaging demonstrated ALTR. The patient's symptoms resolved following head and liner exchange with ceramic head and titanium sleeve. Literature review Previous studies have reported ALTR secondary to head-neck taper corrosion in cobalt chrome alloy and titanium alloy stems used in metal-on-polyethylene (MoP) THA. The stems described above span 4 manufacturers with varying taper geometries. To our knowledge, this is the first report of ALTR due to head-neck taper corrosion in a Stryker Meridian titanium-molybdenum-zirconium-iron (TMZF) alloy stem. Clinical relevance Close surveillance for ALTR may be considered in patients with this prosthesis. Further investigation of the TMZF alloy and V40 taper geometry of this stem may guide future implant design.
Refixation, Allograft and Adjuvant Cell Therapy to Treat Nonunion of the Femoral Neck in a Child
Authors: Magnani Marina , Trisolino Giovanni , Stilli Stefano 
Published: October 2016

Introduction Idiopathic posttraumatic nonunion is a rare condition in children; the treatment of this complication is still controversial in this peculiar population. Case report We report a case of a subcapital type II femoral neck fracture, in a 12-year-old boy, which was initially treated by internal fixation and subsequently went on to a nonunion at the femoral neck, in absence of infection or other disease. 1 year after index surgery we performed surgical debridement and refixation with plate and bone allograft, added with autologous bone marrow aspiration concentrate (BMAC) and platelet-rich fibrin (PRF). After 3 months the nonunion healed and the boy was allowed full weight-bearing. Conclusions Combined surgery and adjuvant cell therapy can be considered an option of treatment in nonunion of the femoral neck in the paediatric population.