bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity
Authors: Muir Lindsey A. , Neeley Christopher K. , Meyer Kevin A. , Baker Nicki A. , Brosius Alice M. , Washabaugh Alexandra R. , Varban Oliver A. , Finks Jonathan F. , Zamarron Brian F. , Flesher Carmen G. , Chang Joshua S. , DelProposto Jennifer B. , Geletka Lynn , Martinez‐Santibanez Gabriel , Kaciroti Niko , Lumeng Carey N. , O'Rourke Robert W. 
Published: February 2016

ObjectiveThe relationship between adipose tissue fibrosis, adipocyte hypertrophy, and preadipocyte hyperplasia in the context of obesity and the correlation of these tissue‐based phenomena with systemic metabolic disease are poorly defined. The goal of this study was to clarify the relationship between adipose tissue fibrosis, adipocyte hypertrophy, and preadipocyte hyperplasia in human obesity and determine the correlation of these adipose‐tissue based phenomena with diabetes.MethodsVisceral and subcutaneous adipose tissues from humans with obesity collected during bariatric surgery were studied with QRTPCR, immunohistochemistry, and flow cytometry for expression of collagens and fibrosis‐related proteins, adipocyte size, and preadipocyte frequency. Results were correlated with clinical characteristics including diabetes status.ResultsFibrosis was decreased, hypertrophy was increased, and preadipocyte frequency and fibrotic gene expression were decreased in adipose tissues from diabetic subjects compared to non‐diabetic subjects. These differences were greater in visceral compared to subcutaneous adipose tissue.ConclusionsThese data are consistent with the hypothesis that adipose tissue fibrosis in the context of human obesity limits adipocyte hypertrophy and is associated with a reciprocal increase in adipocyte hyperplasia, with beneficial effects on systemic metabolism. These findings suggest adipose tissue fibrosis as a potential target for manipulation of adipocyte metabolism.
Effects of liraglutide in hypothalamic arcuate nucleus of obese mice
Authors: Barreto‐Vianna Andre R.C. , Aguila Marcia B. , Mandarim‐de‐Lacerda Carlos A. 
Published: February 2016

ObjectiveThe neuroprotective effects of liraglutide (200 μg/kg, twice daily, subcutaneous administration) in the hypothalamic arcuate nucleus (ARC) of diet‐induced obese mice were investigated.MethodsC57BL/6 mice were separated into groups: standard chow treated with vehicle or liraglutide and the respective liraglutide pair‐fed group; high‐fat diet treated with vehicle or liraglutide and the respective pair‐fed group. Body mass (BM) evolution, carbohydrate metabolism, leptin resistance, proteins involved in energetic balance, apoptosis, and microglia in the ARC were studied.ResultsObese animals showed glucose intolerance, resistance to insulin and to anorexigenic effect of leptin, and microgliosis accompanied by elevated Bax/Bcl2 ratio in the ARC. Liraglutide improved the carbohydrate metabolism, BM loss, and the activation of pro‐opiomelanocortin (POMC) and cocaine and amphetamine‐regulated transcript (CART) in the ARC. The liraglutide enhanced leptin sensitivity and diminished the microgliosis with decrease in Bax/Bcl2 ratio.ConclusionsLiraglutide activates central anorexigenic pathways, thereby diminishing the energy intake of obese mice and improving the metabolic parameters related to obesity. Liraglutide is a relevant neuroprotective agent, which can decrease the microgliosis and stimulate the anti‐apoptotic pathway, a significant effect in the treatment of obesity and its comorbidities. Some benefits of liraglutide are independent of the BM loss, which usually accompanies the drug administration.
Effects of roux‐en‐Y gastric bypass surgery on postprandial fructose metabolism
Authors: Surowska Anna , De Giorgi Sara , Theytaz Fanny , Campos Vanessa , Hodson Leanne , Stefanoni Nathalie , Rey Valentine , Schneiter Philippe , Laville Martine , Giusti Vittorio , Gabert Laure , Tappy Luc 
Published: February 2016

ObjectiveFructose is partly metabolized in small bowel enterocytes, where it can be converted into glucose or fatty acids. It was therefore hypothesized that Roux‐en‐Y gastric bypass (RYGB) may significantly alter fructose metabolism.MethodsWe performed a randomized clinical study in eight patients 12‐17 months after RYGB and eight control (Ctrl) subjects. Each participant was studied after ingestion of a protein and lipid meal (PL) and after ingestion of a protein+lipid+fructose+glucose meal labeled with 13C‐fructose (PLFG). Postprandial blood glucose, fructose, lactate, apolipoprotein B48 (apoB48), and triglyceride (TG) concentrations, 13C‐palmitate concentrations in chylomicron‐TG and VLDL‐TG, fructose oxidation (13CO2 production), and gluconeogenesis from fructose (GNGf) were measured over 6 hours.ResultsAfter ingestion of PLFG, postprandial plasma fructose, glucose, insulin, and lactate concentrations increased earlier and reached higher peak values in RYGB than in Ctrl. GNGf was 33% lower in RYGB than Ctrl (P = 0.041), while fructose oxidation was unchanged. Postprandial incremental areas under the curves for total TG and chylomicrons‐TG were 72% and 91% lower in RYGB than Ctrl (P = 0.064 and P = 0.024, respectively). ApoB48 and 13C‐palmitate concentrations were not significantly different.ConclusionsPostprandial fructose metabolism was not grossly altered, but postprandial lipid concentrations were markedly decreased in subjects having had RYGB surgery.
Bronchopulmonary dysplasia impairs L‐type amino acid transporter‐1 expression in human and baboon lung
Authors: Bao Erik L. , Chystsiakova Anastasiya , Brahmajothi Mulugu V. , Sunday Mary E. , Pavlisko Elizabeth N. , Wempe Michael F. , Auten Richard L. 
Published: February 2016

SummaryBronchopulmonary dysplasia (BPD) is an inflammatory lung disorder common in premature infants who undergo mechanical ventilation with supplemental oxygen. Inhaled nitric oxide (iNO) has been used to prevent experimental and clinical BPD. Earlier studies showed that NO effects in alveolar epithelial cells (AEC) are mediated by S‐nitrosothiol uptake via L‐type amino acid transporter‐1 (LAT1). Because LAT1 expression could influence the efficacy of iNO therapy, we sought to determine whether pulmonary LAT1 expression is altered in preterm baboons with experimental BPD and in human newborns susceptible to developing BPD. Using fixed lung obtained from 125 d to 140 d gestation baboon models of BPD, LAT1 immunostaining was measured in control and BPD animals. In adult controls and in 140 d gestational controls (GC), LAT1 was expressed in both type I and type II AECs. In 140 d BPD lungs, LAT1 expression density in alveolar tissue was decreased. In 125 d GC baboons, LAT1 immunostaining was largely confined to cuboidal AECs, whereas animals given 14 d of mechanical ventilation exhibited diminished alveolar septal LAT1 Labeling. The pattern in adult human donor lung was comparable to that observed in adult baboons. LAT1 was expressed in lungs obtained from some but not all very premature newborns at autopsy. In human and baboon lung, adult and newborn, pulmonary vascular cells expressed LAT1. In summary, LAT1 is expressed in AECs and pulmonary vascular cells in baboons and humans. Experimental BPD in premature baboons decreases pulmonary LAT1 expression and alters its spatial localization. Heterogeneity of functional LAT1 could affect S‐nitrosothiol importation, which could impair iNO therapy. Pediatr Pulmonol. 2016;51:1048–1056. © 2016 Wiley Periodicals, Inc.
Visualizing information worldwide a panel proposal to the 2015 ASIS&T annual meeting sponsored by: SIG‐VIS, SIG‐III, & SIG‐HFIS
Authors: Hartel Jenna 
Published: February 2016

ABSTRACTTwelve scholars based at information programs worldwide have recently participated in research that asks: How is the concept of information visualized in my community and beyond? The study employed an arts‐informed, visual methodology and the draw‐and‐write technique to stimulate local and global conversations about the pictorial nature of information in society. The work has generated new insights into information as a visual phenomenon and generated an archive of “iSquare” images to be used for information research, education, and practice. As a contribution to the conference theme of “Impact on Society,” this panel introduces the project, describes its technical infrastructure, highlights emerging social scientific and artistic outcomes, and reports cross‐cultural discoveries. The multimedia and interactive session will include in‐person presentations, short videos from collaborators overseas, an expert discussant, dialogue with the audience, and an art exhibition.
The right to be forgotten
Authors: Jones Meg Leta , Zeide Elana , Mai Jens‐Erik , Jones Elisabeth , Dupre Jill , Richards Neil 
Published: February 2016

ABSTRACTThe right to be forgotten gained international attention in May 2014, when the European Court of Justice ruled that Google was obligated to recognize European citizens’ data protection rights to address inadequate, irrelevant, or excessive personal information. As of April 14, 2015, Google received 239,337 requests to eliminate 867,930 URLs from search results and has removed 305,095 URLs, a rate of 41.5 percent. The right to be forgotten is intended to legally address digital information that lingers and threatens to shackle individuals to their past by exposing the information to opaque data processing and online judgment. There are a number of challenges to developing these rights – digital information means and touches so many aspects of life across cultures as they grapple with new policies. The controversial ruling and establishment of such a right, potential for a similar movement in the U.S., and future of transborder data flows will be discussed by this esteemed panel.
A real‐time web observatory for cycling safety: A tool for supporting research and decision making of people and organizations
Authors: González‐Ibáñez Roberto , Bonacic Carolina , Fernández Álvaro 
Published: February 2016

ABSTRACTHuman‐generated content on the Web has increased over the last decade. In part, this situation has been powered by the proliferation of social networking services and mobile computing. In the context of citizen safety, everyday people share information about safety‐related events such as natural disasters, accidents, and theft. This information can have valuable implications for the community and authorities, however, processing and making sense of such volume of information are difficult tasks for machines and likely impossible for humans. This poster shows the design of a real‐time Web observatory that uses publicly available information found in social networking services such as Twitter to automatically provide visualizations and indicators of safety‐related events for the particular case of cyclists as perceived by the citizens. We demonstrate the potential applications of this design with two implementations thought to aid researchers, decision makers, and people in general.
Development of the missouri hub: Preparing for linked open data by contributing to the digital public library of America
Authors: Freeland Chris , Moulaison Heather 
Published: February 2016

ABSTRACTLinked data presents numerous implementation challenges in cultural heritage institutions. The Digital Public Library of America (DPLA) has emerged as a resource for cultural heritage institutions to contribute metadata records for their digital assets to a national aggregation platform, one that is actively being developed to express contributed metadata as linked data. At present, there is a dearth of literature on the DPLA, and especially on its hubs. This poster aims to fill that gap by documenting the formation of the Missouri Hub, the DPLA Service Hub for Missouri, as a model for institutions with similar collective goals of exposing and enriching their data through the DPLA. Using Rogers's () Diffusion of innovations theory, we apply a post‐implementation descriptive application of Rogers's model for the innovation process in an organization to the formation of the Missouri Hub. The five steps to implementation are presented, including the initiation and decision process. This poster presents and analyzes one approach to adopting and implementing the DPLA, an innovation supporting cultural heritage institutions and their goals of exposing and enriching their data. By working collaboratively, the institutions were able to achieve a goal that they could not attain individually.
Determining users' motivations to participate in online community archives: A preliminary study of documenting ferguson
Authors: Freeland Chris , Atiso Kodjo 
Published: February 2016

ABSTRACTThe shooting death of teenager Michael Brown in Ferguson, Missouri, spurred an immediate national and international response in the fall of 2014. Washington University Libraries in St. Louis, Missouri, established the Documenting Ferguson web archive to gather digital media documenting local protests and demonstrations as captured by community members in order to archive the materials for future research and scholarly use. This preliminary study identified the factors that motivated participants to contribute content to the Documenting Ferguson online community archive, uncovering themes of altruism, reciprocity, and personal development.
Media visualization of book cover images: Exploring differences among bestsellers in different countries
Authors: Jeong Wooseob , Han Hyejung 
Published: February 2016

ABSTRACTInterest in the role of book cover images in readers’ reading experience and book marketing has been long‐standing. This study attempts to compare book covers from different countries with a media visualization tool called ImagePlot. The top 100 bestselling books from 13 Amazon.com's international sites were identified and their cover images were downloaded. Using ImagePlot, median values of brightness, hue and saturation for each image in the data set were extracted and analyzed. Along with one‐way ANOVA tests by SPSS, ImagePlot outputs show differences in these graphical properties of bestsellers’ cover images in different countries. From the outputs, with all the book cover images displayed on a single canvas (screen), hidden patterns emerged and findings were clearly confirmed. This study makes a contribution by providing connection between research interests in book cover images and media visualization techniques for further research.
Data informed learning: A next phase data literacy framework for higher education
Authors: Maybee Clarence , Zilinski Lisa 
Published: February 2016

ABSTRACTAccessing, using and managing data is increasingly recognized as an important learning outcome in higher education. Approaches to data literacy have typically been informed by information literacy. New approaches to information literacy have emerged that address how information is used in the different disciplinary contexts in which people learn and work. Successful approaches to data literacy will also need to address contextual concerns. Informed learning is an approach to information literacy that purposefully addresses contextual concerns by suggesting pedagogic strategies for enabling students to use information in ways that support discipline‐focused learning outcomes. As part of an ongoing investigation, we advance data informed learning as a framework for data literacy in higher education that emphasizes how data are used to learn and communicate within disciplinary learning contexts. Drawing from informed learning, we outline principles and characteristics of data informed learning, and suggest future directions to investigate ways that data are used in real‐world environments.
Data management and curation practices: The case of using DSpace and implications
Authors: Zhang Yin , Chen Hsin‐liang 
Published: February 2016

ABSTRACTData management and curation is a new challenge with the emerging trend of data‐dependent scholarly research. Due to the lack of common standards and best practices, current data management and curation practices have been varied. This poster presents a project that examines the common practices of data management and curation that helps understand the scope of and factors behind such variations. The sample of this study consists of 171 unique data repositories created by 164 institutions from 95 countries worldwide. The preliminary results indicate that data management and curation is a global issue. Currently, academic institutions and government agencies are the leading force in contributing and sharing data. Data repositories are used for various purposes with international repository and learning resources being the most common use cases. Additionally, system functions used to manage data repositories vary to a great extent with statistics and OAI harvesting being the most common ones.
Inclusive museum and its impact on learning of special needs children
Authors: Deng Liya 
Published: February 2016

ABSTRACTThis study investigates the effect of learning in museums, an informal environment different from the traditional classroom, on children with special needs. The purpose of the project is to examine how the museum experience influences learning and socialization of children with developmental disorders. The author aimed to quantify and understand the value and impact of the museum experience through a mixed methods study design. Both quantitative and qualitative data were collected through a standardized scale, observations, parental surveys, and pre‐ and post‐activity task evaluations. The results revealed a positive impact of the museum learning on knowledge acquisition and socialization demonstrated by increases in the total number of the participants’ information sharing and communication behaviors. The study contributes to improving our understanding of information and cultural needs of children with disabilities in an unconventional learning environment. It also raises public awareness of museums’ capacity to serve increasingly diverse user communities and provide wider access to cultural heritage.
What flavors are different types of scholarly articles? An investigation of PLOS publications
Authors: Xu Shenmeng , Hemminger Bradley M. 
Published: February 2016

ABSTRACTUsing Article‐Level‐Metrics (ALMs) data from PLOS, we analyze the citations, views, saves, and shares of different types of articles. Using multiple statistical and visualization techniques, we explore scientists’ behaviors associated with scholarly works, which could help us better understand their information needs, and provide clues about how different types of scholarly information are valued. We find that scholarly impact could be better interpreted when article types are taken into consideration. Moreover, the correlations between citations, views, saves, and shares also demonstrate the need to consider article types when assessing the validity of altmetrics. Since altmetrics usage data are associated with various information behaviors, we advocate that altmetrics, especially only the scores, should be used with caution. In summary, our approach provides a novel point of view to explore altmetrics and citation data. Future work will adopt quality approaches to look into more details of the current analyses, to get a better understanding of flavors of scholarly impact.
Evaluating fan fiction metadata for preservation use
Authors: Gursoy Ayse 
Published: February 2016

ABSTRACTThe preservation of ergodic digital artifacts, such as videogames, is a complex and uncertain archival task. This study examines how fan fiction metadata can facilitate the preservation of digital experiences. Based on a preliminary assessment of fan fiction associated with the videogame Mass Effect, collections of fan fiction metadata constitute a promising resource to identify and document player experiences, particularly those involving game characters and their relationships.
The research of mobile internet user's behavior: From the perspective of individual's regulatory focus
Authors: Zhu Peng , Wu Wei , Zhao Xiaoxiao , Xu Mengying 
Published: February 2016

ABSTRACTAlthough many reports showed that the mobile Internet market has great potential to appeal to a broader range of users, there are few studies on mobile Internet behavior. In this paper, we mainly researched the effects of mobile Internet user's motivation orientation on behavior, drawing on regulatory focus theory and combining with individual innovation, perceived risk, perceived value and connection quality. Then we used the Structural Equation Model to verify the hypothesis. The results showed that mobile Internet user's motivation orientation directly influences individual innovation and usage intention. Compared with the prevention focus users, promotion focus users’ innovation is higher and their intention to use mobile Internet is more intense. These results could provide further guidance for mobile Internet providers’ operation strategies.
Online question answering practices to support healthcare data re‐use
Authors: Blake Catherine , Souden Maria , Anderson Caryn L. , Twidale Michael , Jenifer E. Stelmack 
Published: February 2016

ABSTRACTInstitutional data collection practices inevitably evolve over time, especially in a distributed clinical setting. Clinical and administrative data can improve health and healthcare, but only if researchers ensure that the data is well‐aligned to their reuse goals and that they have adequately accounted for changes in data collection practices over time. Our goal is to understand information behaviors of health services data users as they bridge the gap between the historical data and their intended data reuse goals. This project leverages more than a decade of listserv posts related to the use of clinical and administrative data by US Department of Veterans Affairs (VA) employees, providing longitudinal insight into data reuse practices in both research and operational settings. In this paper we report the results of a pilot study that highlighted questions raised in the use of data and the knowledge engaged to answer them.
Digital latin library: Information work practices of classics scholars, graduate students, and teachers
Authors: Abbas June , Baker Stacey Renee , Huskey Samuel J. , Weaver Chris 
Published: February 2016

ABSTRACTInitial results of an information behavior study of Classics scholars of Latin, graduate students, and high school teachers are presented. The study was conducted to inform the design of the Digital Latin Library. Interviews and task demonstrations were conducted with 16 participants. Findings indicate user groups use a variety of specialized print and digital resources, with a preference for print manuscripts, and that they employ basic and advanced searching techniques but also require domain‐specific tools to conduct their scholarly work activities.
Neighborhood‐level index of knowledge and intellectual capital
Authors: Bedford Denise A. D. , Kelley Sean , Bible Geoffrey , Kollinger Justin , Savage Kelsey , Brown Gabrielle , Sabatiuk Liz 
Published: February 2016

ABSTRACTThis poster presents a rationale and architecture for a neighborhood‐ and city‐level index of knowledge and intellectual capital. The Index is grounded on established models of intellectual capital and knowledge transactions. The architecture includes seven components that support analytics and engagement. The analytics component includes data harvesting, harmonization, management, dashboards and reports. The engagement component is grounded on GIS components and is designed to enable a city's citizens to leverage the Index to achieve their vision of a Knowledge City. Six facets of a Knowledge City are defined, and factors that contribute to the incentivizing or Disincentivizing of knowledge transactions are proposed. The model and methodology are currently being implemented in four cities – Columbus and Youngstown Ohio, Baltimore Maryland, and Fredericksburg Virginia.