bluuebunny/crossref_metadata_2025_split huggingface dataset:
z > 4 low luminosity dusty galaxy candidates in the Frontier Fields A2744, AS1063 and A370
Authors: Boone Frédéric , Schaerer Daniel , Richard Johan , Clément Benjamin , Egami Eiichi , Rawle Tim , Lutz Dieter , Weiss Axel , Staguhn Johannes G. ,   HLS team
Published: October 2016

AbstractWe have conducted a LABOCA 870 μm follow-up of ten massive lensing clusters of the Herschel Lensing Survey (HLS, Egami et al. 2010) aiming at unveiling the yet hidden part of dusty star formation in the distant Universe. Among these clusters, A2744 and AS1063 are part of the Frontier Fields HST program. We also obtained 2 mm bolometer observations of A2744 and A370 with the GISMO array at the IRAM 30 m. We detected sources that are undetected with Herschel (PACS and SPIRE) implying either a very high redshift (z > 4) or a very low dust temperature (T<25 K). Their flux also imply a low intrinsic luminosity, LFIR < 1012L⊙. Some of them are extended and could correspond to multiple sources or to multiple images of a lensed source. Substructures in the Sunyaev-Zeldovich effect could also contribute this very red submm emission. An ALMA program is ongoing to unveil the nature of these sources.
“Enough of Being Basely Tearful”: “Glitter and Be Gay” and the Camp Politics of Queer Resistance
Authors: JONES MATTHEW J. 
Published: October 2016

AbstractUpon its publication in 1759, Voltaire'sCandide, or The Optimistscandalized Europe. Banned for its blasphemous and politically seditious content, it became asuccès de scandaleand one of the most widely read books of its time. Leonard Bernstein adapted Voltaire's work for the stage in the 1950s. With its emphasis on the improbable, the artificial, and the insouciant,Candidepractically begs for a camp (re)interpretation, and it is just such an analysis I offer here. After outlining camp as social critique, I turn to Cunégonde's aria “Glitter and Be Gay” and trace its path through camp's causeways in two different decades: first, in the United States of the 1950s, a period marked by McCarthy's witch-hunts, Cold War anxieties, intense homophobia, and the composer's personal struggle to accept his homosexuality, and second, in the late 1980s, when singer, songwriter, and AIDS activist Michael Callen (1955–1993) recorded his own camped-up version of “Glitter and Be Gay” for what would become his last musical project, a posthumous double album entitledLegacy(1996). By following Cunégonde's sparkling trail of glitter and gemstones through two historical moments, I demonstrate how camp functions as a tool of queer resistance across the last half of the twentieth century.
Assembly Lines and Contra Dance Lines: The Ford Motor Company Music Department and Leisure Reform
Authors: BRUCHER KATHERINE 
Published: October 2016

AbstractThe automaker Henry Ford founded the Ford Motor Company Music Department in 1924 with the goal of reviving what he called “old-fashioned dancing and early American music.” Ford's interest in the Anglo-American social dances of his youth quickly grew from dances hosted by the Fords for company executives to a nationwide dance education program. This article traces the history of the Music Department's dance education program and examines the parallels between it and the company's earlier efforts in social engineering—namely the Ford Profit Sharing Plan (better known as the “Five Dollar Day”) and the Ford English School. The Music Department's activities offer an opportunity to explore how industry sought to shape music and dance through Americanization efforts and leisure reform as Detroit rapidly urbanized during the first decades of the twentieth century. Supporters of Ford's revival viewed the restrained musical accompaniment and dance movements as an antidote to jazz music and dances, but more importantly, music and dance served as an object lesson in the physical discipline necessary for assembly line labor. Ford's dance education campaign reveals the degree to which industry was once entwined with leisure reform in southeast Michigan.
PARP1 regulates the protein stability and proapoptotic function of HIPK2
Authors: Choi Jong-Ryoul , Shin Ki Soon , Choi Cheol Yong , Kang Shin Jung 
Published: October 2016

AbstractHomeodomain-interacting protein kinase 2 (HIPK2) is a nuclear serine/threonine kinase that functions in DNA damage response and development. In the present study, we propose that the protein stability and proapoptotic function of HIPK2 are regulated by poly(ADP-ribose) polymerase 1 (PARP1). We present evidence indicating that PARP1 promotes the proteasomal degradation of HIPK2. The tryptophan-glycine-arginine (WGR) domain of PARP1 was necessary and sufficient for the promotion of HIPK2 degradation independently of the PARP1 enzymatic activity. The WGR domain mediated the interaction between HIPK2 and C-terminus of HSP70-interacting protein (CHIP) via HSP70. We found that CHIP can function as a ubiquitin ligase for HIPK2. The interaction between PAPR1 and HIPK2 was weakened following DNA damage. Importantly, PARP1 reduced the HIPK2-mediated p53 phosphorylation, proapoptotic transcriptional activity and cell death. These results suggest that PARP1 can modulate the tumor-suppressing function of HIPK2 by regulating the protein stability of HIPK2.
BUB1 and SURVIVIN proteins are not degraded after a prolonged mitosis and accumulate in the nuclei of HCT116 cells
Authors: Andonegui-Elguera Marco A , Cáceres-Gutiérrez Rodrigo E , Luna-Maldonado Fernando , López-Saavedra Alejandro , Díaz-Chávez José , Cisneros-Soberanis Fernanda , Prada Diddier , Mendoza-Pérez Julia , Herrera Luis A 
Published: October 2016

AbstractSpindle poisons activate the spindle assembly checkpoint and prevent mitotic exit until cells die or override the arrest. Several studies have focused on spindle poison-mediated cell death, but less is known about consequences in cells that survive a mitotic arrest. During mitosis, proteins such as CYCLIN B, SECURIN, BUB1 and SURVIVIN are degraded in order to allow mitotic exit, and these proteins are maintained at low levels in the next interphase. In contrast, exit from a prolonged mitosis depends only on degradation of CYCLIN B; it is not known whether the levels of other proteins decrease or remain high. Here, we analyzed the levels and localization of the BUB1 and SURVIVIN proteins in cells that escaped from a paclitaxel-mediated prolonged mitosis. We compared cells with a short arrest (HCT116 cells) with cells that spent more time in mitosis (HT29 cells) after paclitaxel treatment. BUB1 and SURVIVIN were not degraded and remained localized to the nuclei of HCT116 cells after a mitotic arrest. Moreover, BUB1 nuclear foci were observed; BUB1 did not colocalize with centromere proteins. In HT29 cells, the levels of BUB1 and SURVIVIN decreased during the arrest, and these proteins were not present in cells that reached the next interphase. Using time-lapse imaging, we observed morphological heterogeneity in HCT116 cells that escaped from the arrest; this heterogeneity was due to the cytokinesis-like mechanism by which the cells exited mitosis. Thus, our results show that high levels of BUB1 and SURVIVIN can be maintained after a mitotic arrest, which may promote resistance to cell death.
Phasic dopamine release in the rat nucleus accumbens predicts approach and avoidance performance
Authors: Gentry Ronny N. , Lee Brian , Roesch Matthew R. 
Published: October 2016

AbstractDopamine (DA) is critical for reward processing, but significantly less is known about its role in punishment avoidance. Using a combined approach-avoidance task, we measured phasic DA release in the nucleus accumbens (NAc) of rats during presentation of cues that predicted reward, punishment or neutral outcomes and investigated individual differences based on avoidance performance. Here we show that DA release within a single microenvironment is higher for reward and avoidance cues compared with neutral cues and positively correlated with poor avoidance behaviour. We found that DA release delineates trial-type during sessions with good avoidance but is non-selective during poor avoidance, with high release correlating with poor performance. These data demonstrate that phasic DA is released during cued approach and avoidance within the same microenvironment and abnormal processing of value signals is correlated with poor performance.
The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation
Authors: Yip Kwok Ho , Kolesnikoff Natasha , Hauschild Nicholas , Biggs Lisa , Lopez Angel F. , Galli Stephen J. , Kumar Sharad , Grimbaldeston Michele A. 
Published: October 2016

AbstractCross-linkage of the high-affinity immunoglobulin E (IgE) receptor (FcɛRI) on mast cells by antigen ligation has a critical role in the pathology of IgE-dependent allergic disorders, such as anaphylaxis and asthma. Restraint of intracellular signal transduction pathways that promote release of mast cell-derived pro-inflammatory mediators is necessary to dampen activation and restore homoeostasis. Here we show that the ligase Nedd4-2 and the adaptor Ndfip1 (Nedd4 family interacting protein 1) limit the intensity and duration of IgE-FcɛRI-induced positive signal transduction by ubiquitinating phosphorylated Syk, a tyrosine kinase that is indispensable for downstream FcɛRI signalosome activity. Importantly, loss of Nedd4-2 or Ndfip1 in mast cells results in exacerbated and prolonged IgE-mediated cutaneous anaphylaxis in vivo. Our findings reveal an important negative regulatory function for Nedd4-2 and Ndfip1 in IgE-dependent mast cell activity.
Molecular basis of cooperativity in pH-triggered supramolecular self-assembly
Authors: Li Yang , Zhao Tian , Wang Chensu , Lin Zhiqiang , Huang Gang , Sumer Baran D. , Gao Jinming 
Published: October 2016

AbstractSupramolecular self-assembly offers a powerful strategy to produce high-performance, stimuli-responsive nanomaterials. However, lack of molecular understanding of stimulated responses frequently hampers our ability to rationally design nanomaterials with sharp responses. Here we elucidated the molecular pathway of pH-triggered supramolecular self-assembly of a series of ultra-pH sensitive (UPS) block copolymers. Hydrophobic micellization drove divergent proton distribution in either highly protonated unimer or neutral micelle states along the majority of the titration coordinate unlike conventional small molecular or polymeric bases. This all-or-nothing two-state solution is a hallmark of positive cooperativity. Integrated modelling and experimental validation yielded a Hill coefficient of 51 in pH cooperativity for a representative UPS block copolymer, by far the largest reported in the literature. These data suggest hydrophobic micellization and resulting positive cooperativity offer a versatile strategy to convert responsive nanomaterials into binary on/off switchable systems for chemical and biological sensing, as demonstrated in an additional anion sensing model.
Hybrid metamaterials for electrically triggered multifunctional control
Authors: Liu Liu , Kang Lei , Mayer Theresa S. , Werner Douglas H. 
Published: October 2016

AbstractDespite the exotic material properties that have been demonstrated to date, practical examples of versatile metamaterials remain exceedingly rare. The concept of metadevices has been proposed in the context of hybrid metamaterial composites: systems in which active materials are introduced to advance tunability, switchability and nonlinearity. In contrast to the successful hybridizations seen at lower frequencies, there has been limited exploration into plasmonic and photonic nanostructures due to the lack of available optical materials with non-trivial activity, together with difficulties in regulating responses to external forces in an integrated manner. Here, by presenting a series of proof-of-concept studies on electrically triggered functionalities, we demonstrate a vanadium dioxide integrated photonic metamaterial as a transformative platform for multifunctional control. The proposed hybrid metamaterial integrated with transition materials represents a major step forward by providing a universal approach to creating self-sufficient and highly versatile nanophotonic systems.
Exploring the intrinsic differences among breast tumor subtypes defined using immunohistochemistry markers based on the decision tree
Authors: Li Yang , Tang Xu-Qing , Bai Zhonghu , Dai Xiaofeng 
Published: October 2016

AbstractExploring the intrinsic differences among breast cancer subtypes is of crucial importance for precise diagnosis and therapeutic decision-making in diseases of high heterogeneity. The subtypes defined with several layers of information are related but not consistent, especially using immunohistochemistry markers and gene expression profiling. Here, we explored the intrinsic differences among the subtypes defined by the estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 based on the decision tree. We identified 30 mRNAs and 7 miRNAs differentially expressed along the tree’s branches. The final signature panel contained 30 mRNAs, whose performance was validated using two public datasets based on 3 well-known classifiers. The network and pathway analysis were explored for feature genes, from which key molecules including FOXQ1 and SFRP1 were revealed to be densely connected with other molecules and participate in the validated metabolic pathways. Our study uncovered the differences among the four IHC-defined breast tumor subtypes at the mRNA and miRNA levels, presented a novel signature for breast tumor subtyping, and identified several key molecules potentially driving the heterogeneity of such tumors. The results help us further understand breast tumor heterogeneity, which could be availed in clinics.
Determining putative vectors of the Bogia Coconut Syndrome phytoplasma using loop-mediated isothermal amplification of single-insect feeding media
Authors: Lu Hengyu , Wilson Bree A. L. , Ash Gavin J. , Woruba Sharon B. , Fletcher Murray J. , You Minsheng , Yang Guang , Gurr Geoff M. 
Published: October 2016

AbstractPhytoplasmas are insect vectored mollicutes responsible for disease in many economically important crops. Determining which insect species are vectors of a given phytoplasma is important for managing disease but is methodologically challenging because disease-free plants need to be exposed to large numbers of insects, often over many months. A relatively new method to detect likely transmission involves molecular testing for phytoplasma DNA in sucrose solution that insects have fed upon. In this study we combined this feeding medium method with a loop-mediated isothermal amplification (LAMP) assay to study 627 insect specimens of 11 Hemiptera taxa sampled from sites in Papua New Guinea affected by Bogia coconut syndrome (BCS). The LAMP assay detected phytoplasma DNA from the feeding solution and head tissue of insects from six taxa belonging to four families: Derbidae, Lophopidae, Flatidae and Ricaniidae. Two other taxa yielded positives only from the heads and the remainder tested negative. These results demonstrate the utility of combining single-insect feeding medium tests with LAMP assays to identify putative vectors that can be the subject of transmission tests and to better understand phytoplasma pathosystems.
Optimization of Optical Absorption of Colloids of SiO2@Au and Fe3O4@Au Nanoparticles with Constraints
Authors: Xue Xiaozheng , Sukhotskiy Viktor , Furlani Edward P. 
Published: October 2016

AbstractWe study the optical response of monodisperse colloids of core-shell plasmonic nanoparticles and introduce a computational approach to optimize absorption for photothermal applications that require dilute colloids of non-interacting particles with a prescribed volume fraction. Since the volume fraction is held constant, the particle concentration is size-dependent. Optimization is achieved by comparing the absorption spectra of colloids as a function of particle size and structure. We demonstrate the approach via application to colloids of core-shell SiO2@Au and Fe3O4@Au nanoparticles with particle sizes that range from 5–100 nm and with the incident wavelength varying from 600–1200 nm. The absorption spectra are predicted using Mie theory and the analysis shows that there is a unique mix of parameters (core radius, shell thickness, wavelength) that maximize absorption, independent of the value of volume fraction. We show that lossy Fe3O4 cores produce a much broader absorption peak with much less sensitivity to variations in particle structure and wavelength than lossless SiO2 cores. This approach can be readily adapted to colloids of nanoparticles with arbitrary materials, shapes and structure using appropriate numerical methods to compute the absorption spectra. As such, it is useful for the rational design of colloids and process variables for a broad range of photothermal applications.
Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents
Authors: Wu Lichuan , Wang Guizhen , Liu Shuaibing , Wei Jinrui , Zhang Sen , Li Ming , Zhou Guangbiao , Wang Lisheng 
Published: October 2016

AbstractMatrine, an active component of root extracts from Sophora flavescens Ait, is the main chemical ingredient of Fufang Kushen injection which was approved by Chinese FDA (CFDA) in 1995 as an anticancer drug to treat non-small cell lung cancer and liver cancer in combination with other anticancer drugs. Owning to its druggable potential, matrine is considered as an ideal lead compound for modification. We delineate herein the synthesis and anticancer effects of 17 matrine derivatives bearing benzo-α-pyrone structures. The results of cell viability assays indicated that most of the target compounds showed improved anticancer effects. Further studies showed that compound 5i could potently inhibit lung cancer cell proliferation in vitro and in vivo with no obvious side effects. Moreover, compound 5i could induce G1 cell cycle arrest and autophagy in lung cancer cells through up-regulating P27, down-regulating CDK4 and cyclinD1 and attenuating PI3K/Akt/mTOR pathway. Suppression of autophagy attenuated 5i induced proliferation inhibition. Collectively, our results infer that matrine derivative 5i bears therapeutic potentials for lung cancer.
Estimating Lion Abundance using N-mixture Models for Social Species
Authors: Belant Jerrold L. , Bled Florent , Wilton Clay M. , Fyumagwa Robert , Mwampeta Stanslaus B. , Beyer Dean E. 
Published: October 2016

AbstractDeclining populations of large carnivores worldwide, and the complexities of managing human-carnivore conflicts, require accurate population estimates of large carnivores to promote their long-term persistence through well-informed management We used N-mixture models to estimate lion (Panthera leo) abundance from call-in and track surveys in southeastern Serengeti National Park, Tanzania. Because of potential habituation to broadcasted calls and social behavior, we developed a hierarchical observation process within the N-mixture model conditioning lion detectability on their group response to call-ins and individual detection probabilities. We estimated 270 lions (95% credible interval = 170–551) using call-ins but were unable to estimate lion abundance from track data. We found a weak negative relationship between predicted track density and predicted lion abundance from the call-in surveys. Luminosity was negatively correlated with individual detection probability during call-in surveys. Lion abundance and track density were influenced by landcover, but direction of the corresponding effects were undetermined. N-mixture models allowed us to incorporate multiple parameters (e.g., landcover, luminosity, observer effect) influencing lion abundance and probability of detection directly into abundance estimates. We suggest that N-mixture models employing a hierarchical observation process can be used to estimate abundance of other social, herding, and grouping species.
Identification of lncRNA functions in lung cancer based on associated protein-protein interaction modules
Authors: Wu Chih-Hsun , Hsu Chia-Lang , Lu Pei-Chun , Lin Wen-Chang , Juan Hsueh-Fen , Huang Hsuan-Cheng 
Published: October 2016

AbstractLong non-coding RNAs (lncRNAs) have been found to play important roles in various biological processes; however, many of their functions remain unclear. In this study, we present a novel approach to identify the lncRNA-associated protein-protein interaction (PPI) modules and ascertain their functions in human lung squamous cell carcinoma. We collected lncRNA and mRNA expression profiles of lung squamous cell carcinoma from The Cancer Genome Atlas. To identify the lncRNA-associated PPI modules, lncRNA-mRNA co-expression networks were first constructed based on the mutual ranks of expression correlations. Next, we examined whether the co-expressed mRNAs of a specific lncRNA were closely connected by PPIs. For this, a significantly connected mRNA set was considered to be the lncRNA-associated PPI module. Finally, the prospective functions of a lncRNA was inferred using Gene Ontology enrichment analysis on the associated module. We found that lncRNA-associated PPI modules were subtype-dependent and each subtype had unique molecular mechanisms. In addition, antisense lncRNAs and sense genes tended to be functionally associated. Our results might provide new directions for understanding lncRNA regulations in lung cancer. The analysis pipeline was implemented in a web tool, available at http://lncin.ym.edu.tw/.
Changes in microbial communities, photosynthesis and calcification of the coral Acropora gemmifera in response to ocean acidification
Authors: Zhou Guowei , Yuan Tao , Cai Lin , Zhang Weipeng , Tian Renmao , Tong Haoya , Jiang Lei , Yuan Xiangcheng , Liu Sheng , Qian Peiyuan , Huang Hui 
Published: October 2016

AbstractWith the increasing anthropogenic CO2 concentration, ocean acidification (OA) can have dramatic effects on coral reefs. However, the effects of OA on coral physiology and the associated microbes remain largely unknown. In the present study, reef-building coral Acropora gemmifera collected from a reef flat with highly fluctuating environmental condition in the South China Sea were exposed to three levels of partial pressure of carbon dioxide (pCO2) (i.e., 421, 923, and 2070 μatm) for four weeks. The microbial community structures associated with A. gemmifera under these treatments were analyzed using 16S rRNA gene barcode sequencing. The results revealed that the microbial community associated with A. gemmifera was highly diverse at the genus level and dominated by Alphaproteobacteria. More importantly, the microbial community structure remained rather stable under different pCO2 treatments. Photosynthesis and calcification in A. gemmifera, as indicated by enrichment of δ18O and increased depletion of δ13C in the coral skeleton, were significantly impaired only at the high pCO2 (2070 μatm). These results suggest that A. gemmifera can maintain a high degree of stable microbial communities despite of significant physiological changes in response to extremely high pCO2.