bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parenteral Nutrition Solution in Cerebrospinal Fluid in Preterm Newborn – a Case Report and Review of the Literature
Authors: Lachowska Monika , Lachowski Krzysztof , Królak-Olejnik Barbara 
Published: April 2016

Introduction Percutaneously inserted central venous catheters (epicutaneo-cava-catheter - ECC) are widely used in neonatal intensive care, facilitating the parenteral nutrition and the treatment of critically ill newborns. This invasive procedure is regarded as safe and associated with low complication rate. Possible life-threatening complications may result from malpositioning of ECC. Paraspinal misplacement of ECC is one of the most serious complications. Case Presentation The authors report a case of misplacement of ECC inserted via left saphenous vein for intravenous feeding. A plane radiograph performed after the procedure showed the line tip at L3-L4 level, supposed to indicate location of the catheter in the vena cava inferior. Three days later, the infant developed neurologic symptoms (lethargy, hypotonia, seizures). Lumbar puncture revealed milky fluid containing parenteral nutrition solution. The infusion was stopped. X-ray with contrast showed the catheterization of the left ascending lumbar vein draining the vertebral venous plexuses. The contrast was highlighting the epidural space. The line was immediately removed resulting in improvement in patient's condition and resolution of all neurological symptoms. There was no sequela of this infiltration and the baby had an uneventful recovery. Follow-up at the age of 12 months showed normal development. Conclusions A percutaneous catheter inserted via a lower limb may inadvertently enter the ascending lumbar vein. As previously reported, a catheter inserted via the left lower limb is a risk factor of this malposition. The life-threatening complications may be avoided by careful verification of ECC position (lateral x-ray, contrast examination). Plain radiography alone may not be sufficient for tip localization.
Unusual Cardiac Metastasis of Uterine Leiomyosarcoma: Case Report and Literature Review
Authors: Artioli Grazia , Borgato Lucia , Calamelli Sara , Azzarello Giuseppe 
Published: April 2016

Background Uterine leiomyosarcoma (LMS) is a rare malignancy of mesenchymal tissues and in advanced stages its prognosis is very poor. Surgery followed by radiotherapy and/or chemotherapy is the treatment of choice for advanced disease. Cardiac metastases are very uncommon and only a few cases have been described to date. Case A 55-year-old woman was referred to our center for a uterine LMS with lung metastases at diagnosis. After 3 lines of chemotherapy for persistent lung disease, CT scan showed suspected thrombosis in the right pulmonary vein, along with disease progression in the lungs. The patient started treatment with low-molecular-weight heparin and a fourth line of chemotherapy. After 3 months of therapy, a new CT scan showed a larger thrombus and she underwent a cardiology visit that revealed an intracardiac mass. Submitting the patient to palliative surgery or radiation therapy was not possible because of the aggressiveness of the lung metastases, so she continued chemotherapy, resulting in disease stabilization. Conclusions Surgery is the best option for intracardiac dissemination of uterine LMS, but when this is not possible based on the performance status of the patient and spread of the disease, the combination of chemotherapy and radiotherapy seems to be the best option according to the literature. In our case we treated the patient only with chemotherapy.
Estimated Health and Economic Outcomes of Racial and Ethnic Tuberculosis Disparities in US-Born Persons
Authors: Swartwood Nicole A. , Li Yunfei , Regan Mathilda , Marks Suzanne M. , Barham Terrika , Beeler Asay Garrett R. , Cohen Ted , Hill Andrew N. , Horsburgh Charles R. , Khan Awal D. , McCree Donna Hubbard , Myles Ranell L. , Salomon Joshua A. , Self Julie L. , Menzies Nicolas A. 
Published: September 2024

ImportanceDespite significant progress made toward tuberculosis (TB) elimination, racial and ethnic disparities persist in TB incidence and case-fatality rates in the US.ObjectiveTo estimate the health outcomes and economic cost of TB disparities among US-born persons from 2023 to 2035.Design, Setting, and ParticipantsGeneralized additive regression models projecting trends in TB incidence and case-fatality rates from 2023 to 2035 were fit based on national TB surveillance data for 2010 to 2019 in the 50 US states and the District of Columbia among US-born persons. This baseline scenario was compared with alternative scenarios in which racial and ethnic disparities in age- and sex-adjusted incidence and case-fatality rates were eliminated by setting rates for each race and ethnicity to goal values. Additional scenarios were created examining the potential outcomes of delayed reduction of racial and ethnic disparities. The potential benefits of eliminating disparities from differences between baseline and alternative scenario outcomes were quantified. Data were analyzed from January 2010 to December 2019.ExposuresNon-Hispanic American Indian or Alaska Native, non-Hispanic Asian, non-Hispanic Black, Hispanic, non-Hispanic Native Hawaiian or Other Pacific Islander, or non-Hispanic White race and ethnicity.Main outcomes and measuresTB cases and deaths averted, quality-adjusted life years gained, and associated costs from a societal perspective.ResultsThe study included 31 811 persons with reported TB from 2010 to 2019 (mean [SD] age, 47 [24] years; 20 504 [64%] male; 1179 [4%] American Indian or Alaska Native persons; 1332 [4%] Asian persons; 12 152 [38%] Black persons; 6595 [21%] Hispanic persons; 299 [1%] Native Hawaiian or Other Pacific Islander persons; and 10 254 [32%] White persons). There were 3722 persons with a reported TB death. Persistent racial and ethnic disparities were associated with an estimated 11 901 of 26 203 TB cases among US-born persons (45%; 95% uncertainty interval [UI], 44%-47%), 1421 of 3264 TB deaths among US-born persons (44%; 95% UI, 39%-48%), and an economic cost of $914 (95% UI, $675-$1147) million from 2023 to 2035. Delayed goal attainment reduced the estimated avertable TB outcomes by 505 (95% UI, 495-518) TB cases, 55 (95% UI, 51-59) TB deaths, and $32 (95% UI, $24-$40) million in societal costs annually.Conclusions and relevanceIn this modeling study of racial and ethnic disparities of TB, these disparities were associated with substantial future health and economic outcomes of TB among US-born persons without interventions beyond current efforts. Actions to eliminate disparities may reduce the excess TB burden among these persons and may contribute to accelerating TB elimination within the US.
Multifunctional Silver‐Enzyme Nanogels Assembly with Efficient Trienzyme Cascades for Synergistic Diabetic Wound Healing
Authors: Ma Yedong , Lai Xiyu , Luo Xi , Luo Zheng , Mao Liuzhou , Zhu Houjuan , Fan Xiaotong , Kong Junhua , Wu Yun‐Long , Li Zibiao , He Chaobin 
Published: September 2024

AbstractDiabetic wound healing presents a persistent clinical challenge, often characterized by prolonged healing times, and can be particularly difficult to achieve in a hyperglycemic environment. In this study, a multi‐functional silver‐enzyme nanogels assembly (Ag‐nGHC) is designed by focusing on the complex diabetic wound environment. Glucose oxidase (GOX), horseradish peroxidase (HRP), and catalase (CAT) are modified within polymeric nanogel layers and assembled into a large enzyme cluster with silver ions. The close attachment of three enzymes ensures fast and continuous consumption of a high level of glucose, generation of oxygen, and hydroxyl radicals (•OH) around the wound site. Meanwhile, the silver ions within the Ag‐nGHC assembly act as an effective agent to kill bacteria. This cascade enzyme system significantly improves the microenvironment of the wound site by reducing bacterium infection and alleviating hypoxia as well as hyperglycemia. Sequentially, the improved environment facilitates the later processes including anti‐inflammatory, re‐epithelialization, and angiogenesis, evidenced by enhancing polarization toward M2 macrophages and increasing CD31 signals in this study. Overall, the Ag‐nGHC materials are proven to achieve multifunctional properties toward complicated diabetic wound healing processes (attributes such as adaptability, hypoxia‐alleviated, anti‐hyperglycemic, antimicrobial, anti‐inflammatory, and angiogenic) and showed great potential for the treatment of chronic diabetic wound.
Soft Multimodal Sensors with Decoupled Multimodality and Minimal Wiring for Wearable Systems
Authors: Lee Dongyoung , Bae Joonbum 
Published: September 2024

AbstractSoft multimodal sensors represent a promising approach for applications in wearable systems and skin‐adhesive devices, benefiting from their flexibility and body compatibility. However, the complexity of sensor wiring design poses challenges while employing multimodal decoupling. Although recent studies have applied various methods, such as adjusting the electrical properties of materials, these methods encounter limitations in signal decoupling when multichannel measurements are implemented. In this study, a signal measurement method utilizing frequency response analysis is developed using a multi‐band band‐stop filter (MBBSF) for multiple multimodal sensors. This approach enables the decoupling of different types of sensors and allows for the simultaneous collection of sensor data through a two‐wire connection. Consequently, it facilitates the concurrent and independent real‐time assessment of strain and force in each sensor. A sensor glove is developed incorporating multiple multimodal sensors with a two‐wire connection to measure grip posture and force. This glove is used effectively to classify unknown objects, thereby demonstrating its practical utility. This practical application provides a promising solution to the complex wiring challenges commonly encountered in multi‐modal sensor wearable systems.
Dual‐Mode Bionic Visual–Olfactory Co‐Sensory for On‐Site Biogenic Amines Recognition and Food Freshness Prediction
Authors: Maimaiti Alituniguli , Zhu Kai , Yan Bing 
Published: September 2024

AbstractThe thriving of high‐performance artificial synaptic neuromorphic platforms poses a significant challenge for creating bionic sensors that can integrate multi‐sensory information. For the purpose of realizing this objective, promising bionic visual‐olfactory co‐sensory artificial synaptic devices are developed based on a hydrogen‐bonded organic framework (Eu@HOF‐12). This probe is capable of dual‐emissive‐responsive to biogenic amines (BAs), which are essential indicators for the evaluation of food freshness. Importantly, it demonstrates outstanding advantages, including high sensitivity, ultrafast responses (<6 s), and practicability of recyclability, which can be combined with smartphones for on‐site BAs detection via the colorimetric and ratiometric hydrogel sensor. Besides, a bionic visual‐olfactory co‐sensory based on the human‐computer interaction platform is constructed, which can realize the identification of five types of BAs with high precision through the specific odor fingerprint. Meanwhile, a logic device is utilized for the rapid identification of food freshness considering the hydrogel sensor's dual‐mode responses to BAs. Overall, this research develops an odor visualization strategy that enables on‐site, real‐time, and sensitive monitoring of food quality assessment. In addition, a quantitative assessment system is designed for fast, damage‐free, and accurate assessment of food freshness, ultimately reducing food waste and generating significant economic value.
In Situ Growth of Suspended Zirconene Islets Inside Graphene Pores
Authors: Mendes Rafael G. , Ta Huy Quang , Gemming Thomas , van Gog Heleen , van Huis Marijn A. , Bachmatiuk Alicja , Rümmeli Mark H. 
Published: September 2024

AbstractExperiments using a transmission electron microscope decomposed zirconium acetylacetonate with an electron beam, forming zirconium nanoparticles on graphene. Continued electron irradiation transformed these nanoparticles into atomically thick zirconium islets (zirconene islets) within the graphene lattice. The electron beam caused zirconium atom dislocations and vacancies that are rapidly refilled, a process repeating until the vacancies evolved into zirconium nanoribbons before breaking. This study offers insights into the electron‐driven growth and degradation of zirconene islets, showcasing a method to fabricate freestanding zirconenes for use as atomically thin coatings in extreme environments.
Tough Cortical Bone‐Inspired Tubular Architected Cement‐Based Material with Disorder
Authors: Gupta Shashank , Moini Reza 
Published: September 2024

AbstractCortical bone is a tough biological material composed of tube‐like osteons embedded in the organic matrix surrounded by weak interfaces known as cement lines. The cement lines provide a microstructurally preferable crack path, hence triggering in‐plane crack deflection around osteons due to cement line‐crack interaction. Inspired by this toughening mechanism and facilitated by a hybrid (3D‐printing/casting) process, the study engineers architected tubular cement‐based materials with the stepwise cracking toughening mechanism, that enables a non‐brittle fracture. Using experimental and theoretical approaches, the study demonstrates the competition between tube size and shape on stress intensity factor from which engineering stepwise cracking can emerge. Two competing mechanisms, both positively and negatively affected by the growing tube size, arise to significantly enhance the overall fracture toughness by up to 5.6‐fold compared to the monolithic brittle counterpart without sacrificing the specific strength. This is enabled by crack‐tube interaction and engineering the tube size, shape, and orientation, which promotes rising resistance‐curves (R‐curve). “Disorder” curves and statistical mechanics parameters are proposed for the first time to quantitatively characterize the degree of disorder for describing the representation of the architected arrangement of materials in lieu of otherwise inadequate “periodicity” classification and misperceived disorder parameters (perturbation and Voronoi tessellation methods).
High‐Capacity Zinc Anode Enabled by a Recyclable Biomass Bamboo Membrane Separator
Authors: Ma Jianfeng , Shi Xin , Wang Zhihui , Zhou Lijun , Liu Xinge , Lu Xihong , Jiang Zehui 
Published: September 2024

AbstractAqueous zinc ion batteries have gained attention as viable energy storage systems, yet the occurrence of detrimental side reactions and Zn dendrite formation undermines the efficiency of Zn anodes. Controlling water activity have proven to be an effective strategy in mitigating these challenges. However, strategies such as electrolyte design and electrode protection layer show weakness to varying degrees. Here, a new oxygen‐functionalized biomass bamboo membrane separator (denoted as BM) is proposed to restrain the activity of water molecules. This BM separator features a unique, multi‐tiered 2D interlayer that facilitates rapid ion diffusion. Additionally, the oxygen functional groups of the BM separator can form hydrogen bonds with water molecules, effectively transforming water molecules from a free state to a bound state. Consequently, the Zn/Zn asymmetric coin cell using BM can work at the ultrahigh rate and capacity of 30 mA cm−2 and 30 mAh cm−2 for more than 80 h while its counterparts using glass fiber can barely work. Moreover, full cells using BM separator exhibited a capacity retention of 89.7% after 1000 cycles at 10 A g−1. This study reveals the important influence of water‐limited activity on Zn anode protection and provides an avenue for the design of novel separator.
Flexible Artificial Tactility with Excellent Robustness and Temperature Tolerance Based on Organohydrogel Sensor Array for Robot Motion Detection and Object Shape Recognition
Authors: Chen Guoqi , Zhang Yunting , Li Shengnan , Zheng Jingxia , Yang Hailong , Ren Jiayuan , Zhu Chanjie , Zhou Yecheng , Chen Yongming , Fu Jun 
Published: September 2024

AbstractHydrogel‐based flexible artificial tactility is equipped to intelligent robots to mimic human mechanosensory perception. However, it remains a great challenge for hydrogel sensors to maintain flexibility and sensory performances during cyclic loadings at high or low temperatures due to water loss or freezing. Here, a flexible robot tactility is developed with high robustness based on organohydrogel sensor arrays with negligent hysteresis and temperature tolerance. Conductive polyaniline chains are interpenetrated through a poly(acrylamide‐co‐acrylic acid) network with glycerin/water mixture with interchain electrostatic interactions and hydrogen bonds, yielding a high dissipated energy of 1.58 MJ m−3, and ultralow hysteresis during 1000 cyclic loadings. Moreover, the binary solvent provides the gels with outstanding tolerance from −100 to 60 °C and the organohydrogel sensors remain flexible, fatigue resistant, conductive (0.27 S m−1), highly strain sensitive (GF of 3.88) and pressure sensitive (35.8 MPa−1). The organohydrogel sensor arrays are equipped on manipulator finger dorsa and pads to simultaneously monitor the finger motions and detect the pressure distribution exerted by grasped objects. A machine learning model is used to train the system to recognize the shape of grasped objects with 100% accuracy. The flexible robot tactility based on organohydrogels is promising for novel intelligent robots.
Metastable CoCu2O3 Nanocrystals from Combustion‐Aerosols for Molecular Sensing and Catalysis
Authors: D'Andria Matteo , Elias Abi‐Ramia Silva Tiago , Consogno Edoardo , Krumeich Frank , Güntner Andreas T. 
Published: September 2024

AbstractMetastable nanostructures are kinetically trapped in local energy minima featuring intriguing surface and material properties. To unleash their potential, there is a need for non‐equilibrium processes capable of stabilizing a large range of crystal phases outside thermodynamic equilibrium conditions by closely and flexibly controlling atomic reactant composition, spatial temperature distribution and residence time. Here, the capture of metastable pseudo‐binary metal oxides at room temperature is demonstrated with scalable combustion‐aerosol processes. By a combination of X‐ray diffraction, electron microscopy and on‐line flame characterization, the occurrence of metastable CoCu2O3 is investigated with controlled crystal size (4–16 nm) over thermodynamically stable CuO and Co3O4. Immediate practical impact is demonstrated by exceptional sensing and stable catalytic performance for air pollutant detection (e.g., 15 parts‐per‐billion benzene) shown for, at least, 21 days. This approach can be extended to various binary, ternary and high entropy oxides with even more components. Also, secondary phases can be loaded on such metastable nanocrystals to access novel materials promising for actuators, energy storage or solar cells.
Engineered Nanoparticles for Enhanced Antitumoral Synergy Between Macrophages and T Cells in the Tumor Microenvironment
Authors: Moon Sangjun , Jung Mungyo , Go Seokhyeong , Hong Jihye , Sohn Hee Su , Kim Cheesue , Kang Mikyung , Lee Byung Joon , Kim Jungwoo , Lim Jinwoong , Kim Byung‐Soo 
Published: September 2024

AbstractT cells and macrophages have the potential to collaborate to eliminate tumor cells efficiently. Macrophages can eliminate tumor cells through phagocytosis and subsequently activate T cells by presenting tumor antigens. The activated T cells, in turn, can kill tumor cells and redirect tumor‐associated macrophages toward an antitumoral M1 phenotype. However, checkpoint molecules expressed on tumor cells impede the collaborative action of these immune cells. Meanwhile, monotherapy with a single immune checkpoint inhibitor (ICI) for either macrophages or T cells yields suboptimal efficacy in cancer patients. To address this challenge, here a nanoparticle capable of efficiently delivering dual ICIs to tumors for both macrophages and T cells is developed. These programmed cell death protein 1 (PD‐1)‐transfected macrophage membrane‐derived nanoparticles (PMMNPs) can target tumors and provide signal‐regulatory protein alpha and PD‐1 to block CD47 and programmed cell death‐ligand 1 (PD‐L1), respectively, on tumor cells. PMMNPs enhance macrophage‐mediated cancer cell phagocytosis and antigen presentation, promote T cell activation, and induce the reprogramming of macrophages toward an antitumoral phenotype. In syngeneic tumor‐bearing mice, PMMNPs demonstrate superior therapeutic efficacy compared to nanoparticles delivering single ICIs and non‐targeted delivery of anti‐CD47 and anti‐PD‐L1 antibodies. PMMNPs capable of augmenting the antitumoral interplay between macrophages and T cells may offer a promising avenue for cancer immunotherapy.
Sb2Te3–Bi2Te3 Direct Photo–Thermoelectric Mid‐Infrared Detection
Authors: Wredh Simon , Dai Mingjin , Hamada Kenta , Rahman Md Abdur , Adanan Nur Qalishah , Zamiri Golnoush , Wu Qing Yang Steve , Zhai Wenhao , Mun Nancy Wong Lai , Dong Zhaogang , Kubo Wakana , Wang Qi Jie , Yang Joel K.W. , Simpson Robert E. 
Published: September 2024

AbstractA compact and responsive thermoelectric photodetector is introduced for the mid‐infrared. By resonantly coupling mid‐infrared light to a Sb2Te3‐Bi2Te3 thermoelectric junction, a thermocouple is formed that is directly heated by narrow‐band mid‐infrared radiation. Near‐perfect absorption is achieved at this hot junction through the resonantly enhanced coupling of light to free‐electrons in the Bi2Te3 and Sb2Te3 materials. The fabricated devices operate at 3.6 µm and demonstrate a responsivity of 10.2 V W−1, a specific detectivity of 4.6  × 106 cm Hz1/2 W−1, and a bandwidth in the order of 1 kHz. The optimal detection wavelength can be spectrally tuned by changing the resonant cavity dimensions. This work shows a path toward miniaturized mid‐infrared detectors and spectrometers with high sensitivity, responsivity, and bandwidth. Importantly, the device presented here is ideal for industrial production, which it is hoped will provide wider access to mid‐infrared technologies for chemical sensing, medicine, and security.
Flexible Near‐Infrared Organic Photodetectors With Ultralow Dark Current by Layer‐by‐Layer Blade Coating
Authors: Zhang Yingze , Chen Wenliang , Miao Junhui , Liu Jun , Wang Lixiang 
Published: September 2024

AbstractNear‐infrared organic photodetector (NIR OPD) is promising for emerging wearable biosensing applications. However, their practical application is hindered by the high dark currents of devices that limit the detection of faint light. In this work, highly sensitive flexible NIR OPDs are presented with ultralow dark currents, fabricated using a layer‐by‐layer blade coating (LBL‐BC) technique. In the active layer, a fully fused‐ring molecule FM2, featuring a fixed molecular skeleton, is employed as an electron acceptor to reduce the trap density. The LBL‐BC method enhances the film order and phase purity of the active layer, significantly reduces the trap density of states, and optimizes the vertical phase separation structure of the thin film, thereby preventing reverse charge injection. As a result, a highly sensitive flexible NIR OPD is developed exhibiting an ultralow dark current density of 4.83 × 10−9 A cm−2 at −0.3 V bias and an extremely low noise current density of 7.65 × 10−15 A Hz−1/2 at 10 Hz, comparable to commercial silicon photodiodes. Furthermore, this flexible device is successfully applied for real‐time monitoring of human heartbeat rate, oxygen saturation, and motion recognition. These findings advance the development of highly sensitive NIR OPDs and their application in wearable biosensing technologies.