bluuebunny/crossref_metadata_2025_split huggingface dataset:
ПРОАТЕРОГЕННІ МЕТАБОЛІЧНІ РОЗЛАДИ ТА ОЦІНКА СИСТЕМИ ПЕРОКСИДАЦІЇ ЛІПІДІВ У КУРЦІВ, ХВОРИХ НА НЕСТАБІЛЬНУ СТЕНОКАРДІЮ
Authors: Solomenchuk T. M. , Bedzay A. O. 
Published: October 2016

<p>РЕЗЮМЕ. Обстежено 68 хворих на нестабільну стенокардію (НС), з яких 23 жінки курці, 24 жінки, які не курили і не зазнавали пасивного впливу куріння та 21 чоловік-курець. У жінок-курців, порівняно з жінками, які не курили та чоловіками-курцями, спостерігалось зростання показників загального холестерину (ЗХС), холестерину ліпопротеїдів низької густини (ХС ЛПНГ), холестерину ліпопротеїдів дуже низької густини (ХС ЛПДНГ), тригліцеридів (ТГ) та активності ПОЛ, а вміст ХС ЛПВГ був нижчим, ніж у жінок-некурців та чоловіків-курців. Рівень церулоплазміну (ЦП) був вищим у чоловіків-курців, ніж у жінок-курців і некурців, в яких рівень ЦП був практично однаковий.</p>
ХАРАКТЕРИСТИКА ВЕГЕТАТИВНОГО СТАТУСА ПОДРОСТКОВ С ГОЛОВНОЙ БОЛЬЮ НАПРЯЖЕНИЯ
Authors: Stepanchenko K. A. 
Published: October 2016

<p>РЕЗЮМЕ. Изучено состояние вегетативной нервной системы у подростков с головной болью напряжения. Установлено, что у подростков с головной болью напряжения присутствуют симптомы вегетативной дисфункции (90 %) с признаками вегетативной дисрегуляции респираторной и кардиоваскулярной систем. Клинические нарушения вегетативного статуса указывают на недостаточную активацию парасимпатического отдела с относительным преобладанием симпатического тонуса, а также на нарушение вегетативной регуляции при нагрузочных пробах, что проявляется недостаточной и парадоксальной вегетативной активностью (чрезмерностью и недостаточностью) вегетативного обеспечения физической деятельности. Эти изменения учащаются с учащением болевых цефалгических эпизодов. </p>
ПОБІЧНІ РЕАКЦІЇ У ХВОРИХ НА НЕЕФЕКТИВНО ЛІКОВАНИЙ ВПЕРШЕ ДІАГНОСТОВАНИЙ ТУБЕРКУЛЬОЗ
Authors: Shevchenko R. M. , Prosvietov Yu. V. , Yasinskyi R. M. , Levich А. V. 
Published: October 2016

<p>РЕЗЮМЕ. Метою дослідження стало встановлення структури побічних реакцій (ПР) та особливостей перебігу туберкульозу у хворих на вперше діагностований неефективно лікований туберкульоз, у яких виникли побічні реакції на протитуберкульозні препарати першого ряду. Проаналізовано 60 історій хвороб пацієнтів. Хворих було поділено на 2 групи: з ПР (І група) – 34 пацієнти, без ПР (ІІ група) – 26 хворих. Визначали статистичну значимість відмінностей між групами за допомогою критерію χ-квадрат, при кількості випадків менше 20 додатково користувалися правкою Єтса. Для аналізу кількісних показників використовували t-критерій Стьюдента. Тривалість інтенсивної фази лікування (з урахуванням терапії за 1 і 2 категоріями разом) у хворих, які мали ПР, була більшою: (188,6±9,5) доз проти (166,2±6,1) доз пацієнтів ІІ групи (р&lt;0,05), за рахунок її подовження через відсутність конверсії мазка мокротиння або негативну рентгенологічну динаміку. У 32,4 % хворих побічні реакції мали клінічні прояви, вимагали відміни протитуберкульозних засобів і не зникали після призначення коригуючої терапії, що призводило до збільшення термінів лікування в інтенсивній фазі на (22,4±3,4) доз, р&lt;0,05. </p>
Natural history of SLC11 genes in vertebrates: tales from the fish world
Authors: Neves João V , Wilson Jonathan M , Kuhl Heiner , Reinhardt Richard , Castro L Filipe C , Rodrigues Pedro NS 
Published: October 2016

Abstract

Background
The SLC11A1/Nramp1 and SLC11A2/Nramp2 genes belong to the SLC11/Nramp family of transmembrane divalent metal transporters, with SLC11A1 being associated with resistance to pathogens and SLC11A2 involved in intestinal iron uptake and transferrin-bound iron transport. Both members of the SLC11 gene family have been clearly identified in tetrapods; however SLC11A1 has never been documented in teleost fish and is believed to have been lost in this lineage during early vertebrate evolution. In the present work we characterized the SLC11 genes in teleosts and evaluated if the roles attributed to mammalian SLC11 genes are assured by other fish specific SLC11 gene members.

Results
Two different SLC11 genes were isolated in the European sea bass (Dicentrarchus. labrax), and named slc11a2-α and slc11a2-β, since both were found to be evolutionary closer to tetrapods SLC11A2, through phylogenetic analysis and comparative genomics. Induction of slc11a2-α and slc11a2-β in sea bass, upon iron modulation or exposure to Photobacterium damselae spp. piscicida, was evaluated in in vivo or in vitro experimental models. Overall, slc11a2-α was found to respond only to iron deficiency in the intestine, whereas slc11a2-β was found to respond to iron overload and bacterial infection in several tissues and also in the leukocytes.

Conclusions
Our data suggests that despite the absence of slc11a1, its functions have been undertaken by one of the slc11a2 duplicated paralogs in teleost fish in a case of synfunctionalization, being involved in both iron metabolism and response to bacterial infection. This study provides, to our knowledge, the first example of this type of sub-functionalization in iron metabolism genes, illustrating how conserving the various functions of the SLC11 gene family is of crucial evolutionary importance.
FMAP: Functional Mapping and Analysis Pipeline for metagenomics and metatranscriptomics studies
Authors: Kim Jiwoong , Kim Min Soo , Koh Andrew Y. , Xie Yang , Zhan Xiaowei 
Published: October 2016

Abstract
Background
Given the lack of a complete and comprehensive library of microbial reference genomes, determining the functional profile of diverse microbial communities is challenging. The available functional analysis pipelines lack several key features: (i) an integrated alignment tool, (ii) operon-level analysis, and (iii) the ability to process large datasets.

Results
Here we introduce our open-sourced, stand-alone functional analysis pipeline for analyzing whole metagenomic and metatranscriptomic sequencing data, FMAP (Functional Mapping and Analysis Pipeline). FMAP performs alignment, gene family abundance calculations, and statistical analysis (three levels of analyses are provided: differentially-abundant genes, operons and pathways). The resulting output can be easily visualized with heatmaps and functional pathway diagrams. FMAP functional predictions are consistent with currently available functional analysis pipelines.

Conclusion
FMAP is a comprehensive tool for providing functional analysis of metagenomic/metatranscriptomic sequencing data. With the added features of integrated alignment, operon-level analysis, and the ability to process large datasets, FMAP will be a valuable addition to the currently available functional analysis toolbox. We believe that this software will be of great value to the wider biology and bioinformatics communities.
BMP-SMAD signalling output is highly regionalized in cardiovascular and lymphatic endothelial networks
Authors: Beets Karen , Staring Michael W. , Criem Nathan , Maas Elke , Schellinx Niels , de Sousa Lopes Susana M. Chuva , Umans Lieve , Zwijsen An 
Published: October 2016

Abstract
Background
Bone morphogenetic protein (BMP) signalling has emerged as a fundamental pathway in endothelial cell biology and deregulation of this pathway is implicated in several vascular disorders. BMP signalling output in endothelial cells is highly context- and dose-dependent. Phosphorylation of the BMP intracellular effectors, SMAD1/5/9, is routinely used to monitor BMP signalling activity. To better understand the in vivo context-dependency of BMP-SMAD signalling, we investigated differences in BMP-SMAD transcriptional activity in different vascular beds during mouse embryonic and postnatal stages. For this, we used the BRE::gfp BMP signalling reporter mouse in which the BMP response element (BRE) from the ID1-promotor, a SMAD1/5/9 target gene, drives the expression of GFP.

Results
A mosaic pattern of GFP was present in various angiogenic sprouting plexuses and in endocardium of cardiac cushions and trabeculae in the heart. High calibre veins seemed to be more BRE::gfp transcriptionally active than arteries, and ubiquitous activity was present in embryonic lymphatic vasculature. Postnatal lymphatic vessels showed however only discrete micro-domains of transcriptional activity. Dynamic shifts in transcriptional activity were also observed in the endocardium of the developing heart, with a general decrease in activity over time. Surprisingly, proliferative endothelial cells were almost never GFP-positive. Patches of transcriptional activity seemed to correlate with vasculature undergoing hemodynamic alterations.

Conclusion
The BRE::gfp mouse allows to investigate selective context-dependent aspects of BMP-SMAD signalling. Our data reveals the highly dynamic nature of BMP-SMAD mediated transcriptional regulation in time and space throughout the vascular tree, supporting that BMP-SMAD signalling can be a source of phenotypic diversity in some, but not all, healthy endothelium. This knowledge can provide insight in vascular bed or organ-specific diseases and phenotypic heterogeneity within an endothelial cell population.
Whole-lesion apparent diffusion coefficient (ADC) metrics as a marker of breast tumour characterization—comparison between ADC value and ADC entropy
Authors: Bougias Haralambos , Ghiatas Abraham , Priovolos Dimitrios , Veliou Konstantia , Christou Alexandra 
Published: October 2016

Objective:
To prospectively assess the role of whole-lesion apparent diffusion coefficient (ADC) metrics in the characterization of breast tumours by comparing ADC value with ADC entropy.

Methods:
49 patients with 53 breast lesions underwent phased-array breast coil 1.5-T MRI. Two radiologists experienced in breast MRI, blinded to the final diagnosis, reviewed the ADC maps and placed a volume of interest on all slices including each lesion on the ADC map to obtain whole-lesion mean ADC value and ADC entropy. The mean ADC value and ADC entropy in benign and malignant lesions were compared by the Mann–Whitney U-test. Receiver-operating characteristic analysis was performed to assess the sensitivity and specificity of the two variables in the characterization of the breast lesions.

Results:
The benign (n = 19) and malignant lesions (n = 34) had mean diameters of 20.8 mm (10.1–31.5 mm) and 26.4 mm (10.5–42.3 mm), respectively. The mean ADC value of the malignant lesions was significantly lower than that of the benign ones (0.87 × 10−3 vs 1.49 × 10−3 mm2 s−1; p &lt; 0.0001). Malignant ADC entropy was higher than benign entropy, without reaching levels of statistical significance (5.4 vs 5.0; p = 0.064). At a mean ADC cut-off value of 1.16 × 10−3 mm2 s−1, the sensitivity and specificity for diagnosing malignancy became optimal (97.1% and 93.7, respectively) with an area under the curve (AUC) of 0.975. With regard to ADC entropy, the sensitivity and specificity at a cut-off of 5.18 were 67.6 and 68.7%, respectively, with an AUC of 0.664.

Conclusion:
Whole-lesion mean ADC could be a helpful index in the characterization of suspicious breast lesions, with higher sensitivity and specificity than ADC entropy.

Advances in knowledge:
Two separate parameters of the whole-lesion histogram were compared for their diagnostic accuracy in characterizing breast lesions. Mean ADC was found to be able to characterize breast lesions, whereas entropy proved to be unable to differentiate benign from malignant breast lesions. It is, however, likely that entropy may distinguish these two groups if a larger cohort were used, or the fact that this may be influenced by the molecular subtypes of breast cancers included.
Risk of ionizing radiation exposure from CT scans in the Neuro ICU - a patient safety blind spot?
Authors: Kumar Avinash B. , Neeley Roy C. 
Published: October 2016

Introduction: The exposure to ionizing radiation has increased significantly with the wide availability of computed tomography (CT) scans and portable imaging technology. We examine the pattern of use of inpatient diagnostic imaging and radiation exposure in the neuro-intensive care unit (Neuro ICU, N-ICU) patient population at a large academic medical center. Methods: We retrospectively evaluated all patients admitted to the Neuro ICU at our academic medical center from January 1 to December 31, 2013. The number and type of CT studies was collected, and the corresponding estimated radiation dose was calculated. We limited the evaluation to CT scans, which accounts for the majority of radiation exposure. Data were electronically collected and cross-referenced to the patients’ electronic medical records (EMR) and radiology records. Radiation dose estimates were calculated based on published reference values and conversion factors (CT head (2mSv)), CT angiography of the head and neck (7-10 mSv), Ct Chest /Abd/pelvis ( 10 mSv), CT cerebral perfusion analysis (3.3 mSv). Results: In the calendar year 2013, we had a total of 2353 admission encounters (F=1078). The mean age on admission was 56.55Y ± 16.7. The mean length of ICU stay was 6.3 days. Mechanical ventilation was initiated on 420 patients with a mean length on mechanical ventilation 5.09 days. 2028 CT scans were completed of which approximately 60% were head CT without contrast (n=1209). 379 patients had multiple CT studies. The mean number of studies was 3.8 ± 2. The number of patients with more thanthree3 studies during their ICU stay was 159. The maximum number of studies on a single patient was 21. Conclusion: Patients in the Neuro ICU are at a risk for significant exposure to ionizing radiation. Radiation exposure must be factored into the culture of quality and patient safety in the ICU.
Embroidered portraiture and the intentional creation of human visibility and value
Authors: White Tanya 
Published: October 2016

Abstract
The aim of my research was to create a portrait following a sequential practice-based process. A mug-shot photograph of a female face was analysed and reinterpreted as an embroidered portrait. Hand-stitched embroidery and embellishment techniques define the facial features and surroundings of the subject matter. The final representation encapsulates my total experience while researching this woman’s image in both a practical and a theoretical way. This encompasses the physical procedures of sketching, painting and embroidering her likeness, with a preoccupation and self-awareness necessary to understand the theories engaged with during these processes. I used an arts-based framework, looking at Michael Podro’s writing ‘Depiction and the concept of subjectification’ in interpreting the portrait subject. In my analysis of the mug shot I drew on Roland Barthes’ theories of ‘essence’ or ‘air’ of a person and his concept of ‘punctum’, the personal and unexplained emotional response caused by a photographic image. Similarly, Gilles Deleuze’s concepts of ‘affection-image’, the ability for a photograph, specifically the extreme close-up of the face or ‘traits of faceiticity’, to move, touch, disturb, disgust... to profoundly affect the viewer with the ‘micro-expressions’ and fine detail magnified in her frozen look. I also referred to Claire Valier’s writings on the ‘punitive power’ of the documentary photograph to punish, shame, shock, elicit guilt or incarcerate as a means of social commentary and an agent of justice (Valier 2004: 254). These philosophies informed the potency and persuasiveness of the photographic content. The picture acts as a visual record of an actual moment that facilitates belief in the accuracy of the event depicted. With this, my female subject represented in the mug shot was a criminal, a prostitute and there was incriminating physical evidence of drug addiction. By transforming the mug shot to a handcrafted embroidered portrait, I intended to remove the stigmatized version of the women. While doing so, I willingly addressed the issues of agency in the subject, viewer and image–maker relationship. These concepts brought forth an intense analysis of my motives and intentions in making the portrait, which eventually lead to an understanding and development of a process that revealed my own translation of my subject’s humanity.
Politicizing motorcycles: Racialized capital of technology, techno-Orientalism and Japanese temporality
Authors: Miyake Esperanza 
Published: October 2016

Abstract
This article politicizes the racialization of motorcycles and critically examines the representation and material consumption of Japanese raciality and technology through motorcyclic discourses. First, referring to online discourses surrounding Harley-Davidson and Japanese motorcycles, I argue that these essentialize and racialize motorcycles, which in turn, through their material consumption, become a technology for classifying, racializing and organizing sociocultural systems of western cultural hegemony. I suggest the term racialized capital of technology as a way of examining and politicizing the ideological-material intersection of racialized technology. Second, through an analysis of Honda’s contemporary advertising discourse (United Kingdom, United States, Japan, World websites), I focus further on the racialization of technology by exploring the ways in which Japan is temporalized through technology. I re-think techno-Orientalist ideas on the future and technology as being ‘Japanized’ and, instead, explore the Japanization of the past through technology, or the historicization of Japanese technology. I argue that Honda’s dual connectivity to the past and the future marks a destabilization of techno-Orientalist discourses of Japan and technology, providing a counter-narrative against western cultural hegemony. However, I am also critical of such discourses and consider some of the historical and ontological tensions surrounding the representation of Japan and technology, relating these to Japanese temporal imperialism and capitalism.
Visualizing post-human and cybersexuality: Lin Pey-Chwen and the Eve Clone series
Authors: Turner Ming 
Published: October 2016

Abstract
This article takes post-human and cybersexuality as the main perspectives from which to contextualize the Taiwanese artist Lin Pey-Chwen’s (born 1959) Eve Clone series, on which she has been working since 2006. It describes how Eve Clone’s virtual body of Eve expresses Lin’s perceptions of the symbols and imaginings of the post-human. The latest Eve Clone series explores issues of femininity, but is also related to the religious symbolism that Lin has adapted in the creation of her work. Although using science and digitality to create art, Lin criticizes technical civilization while reclaiming the importance of nature. In Portrait of Eve Clone, the cyborg body has been created from the main technical operation of digital technology, and this adaptation of a digital body examines the discourses of both the body and sexuality. Lin’s Eve Clone has created a perfect being in cyberspace through artistic aesthetics and new media technologies.
Zones of seeing: Artistic, touristic and digital images of the DMZ
Authors: Kennedy Beccy 
Published: October 2016

Abstract
The article examines visual elements of the Korean Demilitarized Zone (DMZ) by considering its spatial and political uniqueness and its attraction for artists and tourists. The case study is contextualized in relation to a research project – ‘Imaging the DMZ’ – which included a visit to the ‘Real DMZ’ art project by Samuso Art Space (2012), which took place within the DMZ itself. The investigation into the ways that the DMZ has been imaged also includes observations of key artworks and conversations with contemporary artists from South Korea who visualize the DMZ, as well as analysis of online images of the area. The article argues that the DMZ’s ambiguous, yet politically divisive ontology is what makes it distinctive and appealing to the imagination of tourists, the media and artists, but that the latter may be best placed to highlight and challenge some of the more static, binary representations of the DMZ and of the two Koreas that circulate within the (post) digital world.
New additions from Brill journals
Authors: Walkden George 
Published: October 2016

The Language Change collection has become substantially larger thanks to the partnership between Brill Publishing and ScienceOpen. All three of the journals presented - Indo-European Linguistics, Journal of Greek Linguistics and Language Dynamics and Change - contain juicy language-change-related papers, and I have added a generous selection of them to the collection. Browse to find out more!
The collection still has its biases, which I'd like to redress: there's a lot on computational phylogenetic work (from arXiv, from more "sciency" OA journals, and from Language Dynamics and Change), and a lot on early Indo-European (from Indo-European Linguistics and Journal of Greek Linguistics). There isn't much on languages outside Europe, and there isn't much in the way of variationist sociolinguistic studies of change in progress. There also isn't much from the grammaticalization and historical pragmatics literature.
These defects can only be remedied if people help out! We need more OA journals in these areas, and more people to get involved with ScienceOpen and other big players in the Open Access scene. You can read more about open access in linguistics at my blog, which tries to summarize and report news across the whole field - not just language change.
It'd also be great to see more reviews! A review by Lauren Collister of a paper in this collection won the Peer Review Week 2016 competition, which is good to see. In the era of post-publication peer review I'm not attempting to be very selective in what I include in this collection - in fact I haven't read the full text of most of the papers. Which papers are top and which are flop is for the readers to decide, and to communicate to each other!
Till next time,
- G.
A Política Nacional de Atenção Integral à Saúde do Homem na Percepção dos Profissionais da Atenção Básica
Authors: Macêdo Maria Ayrlles , Ribeiro Marco Túlio Aguiar Mourão , Oliveira Francisca Bezerra de , Bezerra Marcos Paulo Egídio , Lima Maria Fabiana De Paula , Sousa Paulo Geovane Bezerra de 
Published: October 2016

Visando diminuir os índices de mortalidade e as morbidades relacionadas ao homem, o Ministério da Saúde delineia ações e políticas que vislumbram reduzir tais índices e atua diretamente na promoção da saúde, prevenção de doenças, tratamento e cura. Com esse propósito foi criada a Política Nacional de Atenção Integral à Saúde do Homem (PNAISH), sendo instituída pela Portaria nº 1.944/GM, de 27 de agosto de 2009. O presente estudo tem como objetivo compreender como a Política Nacional de Atenção Integral à Saúde do Homem está sendo executada em um munícipio da Região Centro-Sul do Ceará e identificar as ações ofertadas pelo referido município para o público masculino no âmbito da Atenção Básica. Trata-se de uma pesquisa exploratória, com abordagem qualitativa. Para a coleta de dados foram utilizadas entrevistas semiestruturadas com 20 profissionais de nível superior, bem como observação não participante e análise documental. A Análise de dados foi pautada pela Análise de Conteúdo na modalidade de Análise Temática de Bardin. Da análise emergiram dois temas: Dificuldades na execução da Política de Saúde do Homem na Atenção Primária e Saúde do Homem na Atenção Básica: ações a serem implementadas. Os resultados revelam que os profissionais da Atenção Básica têm um pouco conhecimento a respeito da Política de Saúde do Homem, tendo dificuldade de executá-la, ou seja, de colocá-la em prática, devido à falta de capacitação, o que leva à não execução de ações integrais e efetivas à Saúde do Homem como preconiza o Ministério da Saúde e a pouca oferta de serviços destinados ao público masculino, no município objeto deste estudo. As ações desenvolvidas em relação à saúde do homem ocorrem de forma pontual, com ênfase no atendimento clínico, prevenção do câncer de próstata e novembro azul. Os residentes em Saúde da Família e Comunidade da Escola de Saúde Pública do Ceará-ESP têm papel importante nesse processo, devem sensibilizar os profissionais e gestores que ofertam os serviços em saúde, objetivando viabilizar na prática ações concretas no campo da Saúde do Homem, evitando possíveis agravos à saúde nesse grupo.