bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contract Choice: Efficiency and Fairness in Revenue‐Sharing Contracts
Authors: Karakostas Alexandros , Sonntag Axel , Zizzo Daniel John 
Published: June 2016

AbstractWe present a simple principal–agent experiment in which the principals are allowed to choose between a revenue‐sharing, a bonus, and a trust contract, to offer to an agent. Our findings suggest that a large majority of experimental subjects choose the revenue‐sharing contract. This choice turns out to be not only the most efficient but also, at the same time, fair. Overall, the distribution of earnings is only mildly skewed towards the principal. We conclude that, under revenue‐sharing contracts, concerns for fairness can be closely associated with the use of monetary incentives.
School Bullying and Moral Reasoning Competence
Authors: von Grundherr Michael , Geisler Anja , Stoiber Manuel , Schäfer Mechthild 
Published: June 2016

AbstractTo examine whether high moral reasoning competence of adolescents is associated with low levels of bullying, and to understand whether moral disengagement mediates or moderates this relationship, 925 German children ranging from 11 to 17 years of age (M = 14.18, SD = 1.21) completed questionnaires on moral reasoning competence and moral disengagement in surveys at three different schools. The children were classified according to their bullying role, based on a peer‐nomination procedure. Multinomial logistic regression analyses showed that moral reasoning competence negatively predicted whether a student took an aggressive role. Moral disengagement partially mediated this relationship. Corresponding effects for defenders and outsiders were not found. These results extend previous findings about the effect of moral reasoning on bullying in primary school. The implications for the prevention of bullying are discussed.
Mutual Positive Emotion with Peers, Emotion Knowledge, and Preschoolers' Peer Acceptance
Authors: Lindsey Eric W. 
Published: June 2016

AbstractPreschool children's emotion knowledge was examined as a possible mediator of the link between their mutual positive emotional expressiveness with peers and peer acceptance. Data were collected from 122 preschool children (57 boys, 65 girls; 86 European American, 9 African American, 17 Hispanic, and 10 other ethnicity; M age = 57.61 months) over a period of 2 years. In year 1 observations were made of children's emotional expressiveness with peers, and children completed sociometric interviews. In year 2, children completed emotion knowledge interviews and sociometric interviews. Analyses revealed that children who expressed more mutual positive emotion with peers in year 1 were better liked by peers in year 2, after controlling for year 1 peer acceptance. Mutual positive emotion in year 1 was associated with children's emotion knowledge in year 2. Both year 1 mutual positive emotion and year 2 emotion knowledge made independent contributions to peer acceptance in year 2.
A Spatial Anomaly Points and Regions Detection Method Using Multi‐Constrained Graphs and Local Density
Authors: Shi Yan , Deng Min , Yang Xuexi , Liu Qiliang 
Published: June 2016

AbstractSpatial anomalies may be single points or small regions whose non‐spatial attribute values are significantly inconsistent with those of their spatial neighborhoods. In this article, a Spatial Anomaly Points and Regions Detection method using multi‐constrained graphs and local density (SAPRD for short) is proposed. The SAPRD algorithm first models spatial proximity relationships between spatial entities by constructing a Delaunay triangulation, the edges of which provide certain statistical characteristics. By considering the difference in non‐spatial attributes of adjacent spatial entities, two levels of non‐spatial attribute distance constraints are imposed to improve the proximity graph. This produces a series of sub‐graphs, and those with very few entities are identified as candidate spatial anomalies. Moreover, the spatial anomaly degree of each entity is calculated based on the local density. A spatial interpolation surface of the spatial anomaly degree is generated using the inverse distance weight, and this is utilized to reveal potential spatial anomalies and reflect their whole areal distribution. Experiments on both simulated and real‐life spatial databases demonstrate the effectiveness and practicability of the SAPRD algorithm.
Optimization of individualized graft composition: CD3/CD19 depletion combined with CD34 selection for haploidentical transplantation
Authors: Huenecke Sabine , Bremm Melanie , Cappel Claudia , Esser Ruth , Quaiser Andrea , Bonig Halvard , Jarisch Andrea , Soerensen Jan , Klingebiel Thomas , Bader Peter , Koehl Ulrike 
Published: June 2016

BACKGROUNDExcessive T‐cell depletion (TCD) is a prerequisite for graft manufacturing in haploidentical stem cell (SC) transplantation by using either CD34 selection or direct TCD such as CD3/CD19 depletion.STUDY DESIGN AND METHODSTo optimize graft composition we compared 1) direct or indirect TCD only, 2) a combination of CD3/CD19‐depleted with CD34‐selected grafts, or 3) TCD twice for depletion improvement based on our 10‐year experience with 320 separations in graft manufacturing and quality control.RESULTSSC recovery was significantly higher (85%, n = 187 vs. 73%, n = 115; p < 0.0001), but TCD was inferior (median log depletion, −3.6 vs. −5.2) for CD3/CD19 depletion compared to CD34 selection, respectively. For end products with less than −2.5 log TCD, a second depletion step led to a successful improvement in TCD. Thawing of grafts showed a high viability and recovery of SCs, but low NK‐cell yield. To optimize individualized graft engineering, a calculator was developed to estimate the results of the final graft based on the content of CD34+ and CD3+ cells in the leukapheresis product.CONCLUSIONFinally, calculated splitting of the starting product followed by CD3/19 depletion together with CD34+ graft manipulation may enable the composition of optimized grafts with high CD34+‐cell and minimal T‐cell content.
Revisiting the Effective Rate of Protection in the Late Stages of Chinese Industrialisation
Authors: Chen Bo , Ma Hong , Jacks David S. 
Published: June 2016

AbstractIn this paper, we generalise conventional measures of the effective rate of protection by: (i) relaxing their small‐country assumptions; (ii) taking into account multiple stages of production; and (iii) abstracting away from their assumptions on the time‐invariance of the underlying technology using annual IO tables. We apply our new measure to China's structure of tariff protection from 1992 to 2010. When compared to conventional measures, we find its effective rates of protection to be smaller in magnitude and even negative in some sectors. The new measures are also related to industry characteristics in sensible ways, calling into question the applicability of conventional measures in the context of present‐day China.
Fibrin‐based stem cell containing scaffold improves the dynamics of burn wound healing
Authors: Chung Eunna , Rybalko Viktoriya Y. , Hsieh Pei‐Ling , Leal Shannah L. , Samano Melissa A. , Willauer Alexandra N. , Stowers Ryan S. , Natesan Shanmugasundaram , Zamora David O. , Christy Robert J. , Suggs Laura J. 
Published: June 2016

ABSTRACTFor severe burn injuries, successful medical intervention is accomplished by rapidly and safely providing physical barriers that can cover damaged skin tissues, thereby preventing critical danger of extensive bleeding and infection. Despite availability of a large assortment of wound coverage options, the etiology of wound healing is rather complex leading to significant defects in skin repair. The use of cell‐mediated treatment approaches in combination with bioengineered wound coverage constructs may provide the missing tool to improve wound healing outcomes. In this study, we have used an engineered 3D PEGylated fibrin (P‐fibrin) gel as a scaffold for adipose derived stem cells (ASCs) delivery into the burn injury model. We were able to confirm the presence of ASCs in the wound site two weeks after the initial injury. Delivery of ASCs‐containing gels was associated with improved vascularization of the injured area at early time points accompanied by an increased abundance of mannose receptor expressing cells. Moreover, the application of P‐fibrin biomaterial exhibited positive effects on early mononuclear cell recruitment and granulation tissue formation without negatively affecting wound closure kinetics or extent of connective tissue deposition. Collectively, our data support the feasibility of using P‐fibrin gels in wound dressing applications requiring controlled delivery of viable cells.
FEASIBILITY OF USING BOLTED SHEAR CONNECTOR WITH COLD-FORMED STEEL IN COMPOSITE CONSTRUCTION
Authors: Muhammad Lawan Mustapha , Md. Tahir Mahmood , Hosseinpour Emad 
Published: June 2016

In conventional composite construction for hot-rolled steel (HRS) section, the composite action is usually achieved by using headed studs shear connectors. But, for cold-formed steel (CFS) section, the use of headed studs is not feasible as the section is very thin and difficult to be weld. Therefore, an innovative way of shear connection mechanism of using bolt and nut is suggested in this study. This paper presents the feasibility of using bolt as shear connector by presenting experimental test results so as to explore more on their capability to be used as shear connectors. The study investigated the structural capability of the proposed bolted shear connector when used in concrete known as Self-compacting concrete (SCC) integrated with CFS to provide the required composite action. Push out test specimens with bolted shear connector of grade 8.8 at designated intervals longitudinally spaced were fabricated, cast and tested to failure. The results showed that the proposed shear connector was structurally capable and also an appreciable strength resistance was achieved.
LABORATORY INVESTIGATION OF DRAINAGE CELL AS TRANSPORT LAYER IN RESIDUAL SOILS
Authors: Haruna Yunusa Gambo , Kassim Azman 
Published: June 2016

Transport layer or unsaturated drainage layer is an alternative measure often employed to improve the performance of a capillary barrier system. A capillary barrier is an earthen cover used to prevent rainfall-induced slope failure. In this study, potential of using drainage cell system as transport layer is exploited using laboratory experimental methods. The drainage cell was sandwiched between grade V and grade VI soils in a two-dimensional laboratory slope model to act as transport layer. Coarse particles of gravel were compacted within the drainage cell to facilitate capillary break development at the interface. Each of grade V and grade VI soil was mixed with water content identical to residual water content determined from the soil water characteristic curves (SWCC) of each soil to enable simulation of their initial condition. Both soils are then compacted in the slope model to their dry densities. The whole set up was subjected to three rainfall intensities of 1.0586 x 10-5 m/s, 1.2014 x 10-6 m/s and 3.7337 x 10-7 m/s for 2 hour, 24 hour and 7 day, respectively. These rainfall intensities were determined from Intensity-Duration-Frequency (IDF) curve and were applied through a rainfall simulator which is part of the laboratory set up. The results shows that the transport layer formed with drainage cell was capable of producing capillary break and impedes percolation of the infiltrating water into the lower grade V soil layer. The accumulated water was later drained laterally above the interface of grade VI soil and drainage cell transport layer towards the toe of the slope model. In an event that the infiltrating water percolates the drainage cell transport layer due to longer rainfall duration, the drainage cell provides a definite direction through which the infiltrating water flow and diverted laterally. It was found that the modified capillary barrier with drainage cell transport layer performed much better than the conventional capillary barrier system.
STREAMFLOW PREDICTION IN UNGAUGED CATCHMENTS IN THE EAST COAST OF PENINSULAR MALAYSIA USING MULTIVARIATE STATISTICAL TECHNIQUES
Authors: Abdul Razaq Salaudeen , Ismail Tarmizi , Heryansyah Arien , Awan Umar Faruk L , Alamgir Mahiuddin , Hadi Pour Sahar 
Published: June 2016

The east coast of Peninsular Malaysia is one of the most vulnerable regions of Malaysia to hydrological disasters, which is believed to become more vulnerable due to climate change. Studies to have better understandings of the hydrological processes in the region are therefore, of paramount importance for disaster risk mitigation. However, unavailability of long-term river discharge data is one of the major constraints of hydrologic studies in the area. The major objective of this study is to predict river discharge in ungauged river basins in the study area. For this purpose, a set of multiple linear regression equations and exponential functions have been developed, which are expressed in the forms of multivariate equations. Available streamflow data along with other catchment characteristics from gauged catchments were used to develop the equations and were subsequently applied to the poorly gauged or ungauged catchments within the study area for prediction of streamflow. In this present study, 4 to 7 explanatory variables were selected as the input variables, which comprise of climatic, geomorphologic, geographic characteristics, soil properties, land use pattern and land cover of the area. Ten flow metrics as maximum, 0.05, 0.10, 0.25, 0.50, 0.75, 0.90, and 0.95, mean and minimum were therefore predicted. Thus, the results of the developed multivariate equations revealed the model to be capable of predicting the desired flow metrics at ungauged catchments in the area under consideration with reasonable accuracy.
The Effect of Contextual Factors on Physiological and Activity Profiles in International Women’s Rugby Sevens
Authors: Goodale Tyler L. , Gabbett Tim J. , Tsai Ming-Chang , Stellingwerff Trent , Sheppard Jeremy 
Published: June 2016

Purpose:To evaluate the effects of contextual game factors on activity and physiological profiles of international-level women’s rugby sevens players.Methods:Twenty international-level female rugby sevens players from the same national team participated in this study. Global positioning system and heart-rate data were collected at 5 World Rugby Women’s Sevens Series events (2013–14 season).Results:Total, moderate-speed (0.2–3.5 m/s), and high-speed running (3.5–5.0 m/s) distances were significantly greater in the first half (20.1% ± 4.1%, 17.6% ± 6.9%, 24.5% ± 7.8%), during losses (11.4% ± 6.1%, 6.1% ± 6.4%, 26.9% ± 9.8%), during losses of large magnitudes (≥2 tries) (12.9% ± 8.8%, 6.8% ± 10.0%, 31.2% ± 14.9%), and against top-4 opponents (12.6% ± 8.7%, 11.3% ± 8.5%, 15.5% ± 13.9%). In addition, total distance increased (5.0% ± 5.5%) significantly from day 1 to day 2 of tournaments, and very-high-speed (5.0–6.5 m/s) running distance increased significantly (26.0% ± 14.2%) during losses. Time spent between 90% and 100% of maximum heart rate (16.4% ± 14.5%) and player load (19.0% ± 5.1%) were significantly greater in the second half. No significant differences in physiological or activity profiles were observed between forwards and backs.Conclusions:Game half, game outcome, tournament day, opponent rank, and margin of outcome all affected activity profiles, whereas game half affected physiological profiles. No differences in activity or physiological profiles were found between playing positions. Practitioners are advised to develop high-speed running ability in women’s rugby sevens players to prepare them to tolerate the varying factors that affect activity profiles.
Difference in Functional Performance on the Upper-Quarter Y-Balance Test Between High School Baseball Players and Wrestlers
Authors: Myers Heather , Poletti Mary , Butler Robert J. 
Published: June 2016

Context:The Upper Quarter Y-Balance Test (YBT-UQ) is a unique movement test where individuals perform at the limits of their stability, requiring the coordination of balance, proprioception, range of motion, and stabilization. It is not yet clear if performance on the YBT-UQ differs between sports with dissimilar emphasis on upper-extremity performance.Objective:To compare performance on the YBT-UQ between wrestlers, whose sport requires some degree of closed-chain activity, and baseball players, whose sport is primarily open kinetic chain in nature.Design:Cross-sectional.Setting:High school preparticipation physical assessment.Participants:24 healthy high school male wrestlers (mean age 16.12 ± 1.24 y) and 24 healthy high school male baseball players (mean age 15.79 ± 1.25 y).Interventions:All subjects performed the YBT-UQ, which requires reaching in 3 directions while maintaining a push-up position.Main Outcome Measures:The variables of interest include the maximum reach in each direction, as well as the composite score. In addition, asymmetries between limbs for each reach direction were compared.Results:Wrestlers performed significantly better than baseball players in the medial direction, inferolateral direction, and in composite scores. In the medial direction, wrestlers exhibited greater scores (P < .01) on both left and right limbs, 10.5 ± 10.2%LL and 9.95 ± 10.2%LL, respectively. Significant differences (P < .01) were also observed in the inferolateral direction, with a difference of 11.3 ± 12.0%LL on the left and 8.7 ± 11.0%LL on the right. Composite scores were higher (P < .01) for the wrestlers, with a difference of 7.0% on the left and 7.1% on the right.Conclusions:This study suggests that wrestlers perform better on the YBT-UQ than baseball players. The findings may suggest sport-specific normative data for the YBT-UQ in high school athletes.
Balance Training Versus Balance Training With STARS in Patients With Chronic Ankle Instability: A Randomized Controlled Trial
Authors: Burcal Christopher J. , Trier Alejandra Y. , Wikstrom Erik A. 
Published: June 2016

Context:Both balance training and selected interventions meant to target sensory structures (STARS) have been shown to be effective at restoring deficits associated with chronic ankle instability (CAI). Clinicians often use multiple treatment modalities in patients with CAI. However, evidence for combined intervention effectiveness in CAI patients remains limited.Objective:To determine if augmenting a balance-training protocol with STARS (BTS) results in greater improvements than balance training (BT) alone in those with CAI.Design:Randomized-controlled trial.Setting:Research laboratory.Patients:24 CAI participants (age 21.3 ± 2.0 y; height 169.8 ± 12.9 cm; mass 72.5 ± 22.2 kg) were randomized into 2 groups: BT and BTS.Interventions:Participants completed a 4-week progression-based balance-training protocol consisting of 3 20-min sessions per week. The experimental group also received a 5-min set of STARS treatments consisting of calf stretching, plantar massage, ankle joint mobilizations, and ankle joint traction before each balance-training session.Main Outcome Measures:Outcomes included self-assessed disability, Star Excursion Balance Test reach distance, and time-to-boundary calculated from static balance trials. All outcomes were assessed before, and 24-hours and 1-week after protocol completion. Self-assessed disability was also captured 1-month after the intervention.Results:No significant group differences were identified (P > .10). Both groups demonstrated improvements in all outcome categories after the interventions (P < .10), many of which were retained at 1-week posttest (P < .10). Although 90% CIs include zero, effect sizes favor BTS. Similarly, only the BTS group exceeded the minimal detectable change for time-to-boundary outcomes.Conclusions:While statistically no more effective, exceeding minimal detectable change scores and favorable effect sizes suggest that a 4-week progressive BTS program may be more effective at improving self-assessed disability and postural control in CAI patients than balance training in isolation.
The first cases of collagenous sprue successfully treated with thioguanine
Authors: van Gils Tom , van de Donk Tine , Bouma Gerd , van Delft Foke , Neefjes-Borst E Andra , Mulder Chris J J 
Published: June 2016

ObjectiveCollagenous sprue (CS) is a rare form of small bowel enteropathy characterised by a thickened basement membrane and is, in most of the literature, reported as part of coeliac disease. Multiple treatment strategies are suggested in CS, but there is no standardised therapy. The aim of this series is to describe 4 cases of CS and to propose thioguanine (6-TG) treatment.DesignWe reviewed 4 cases of CS. Data were obtained from our prospective database of patients referred to our coeliac centre. Evaluation of small bowel biopsies was performed by an expert pathologist.ResultsNone of the patients had ever had coeliac-specific antibodies, and all were negative for HLA-DQ2 and HLA-DQ8 phenotype. Three patients were treated with a combination of 6-TG and budesonide, and 1 patient received 6-TG only. All patients improved remarkably. Normalisation of the thickened basement membrane was found in 2 patients and complete histological improvement including full recovery of villi was found in 1 patient. In the third patient, the thickened basement membrane was only very focally recognised. The thickened membrane persisted in the last patient, probably because of the short time of follow-up.ConclusionsCS should be separated from coeliac disease. Based on the lack of typical HLA phenotyping and the absence of coeliac-specific antibodies, there seems to be no relation with coeliac disease in these 4 cases. A promising treatment option might be 6-TG with or without budesonide. Research in a larger cohort is needed to standardise treatment for CS.
Bivariate evaluation of thromboembolism and bleeding in clinical trials of anticoagulants in patients with atrial fibrillation
Authors: Steg Philippe Gabriel , Halperin Jonathan L. , Goldenberg Neil A. , Schulman Sam , Spyropoulos Alex C. , Kessler Craig M. , Turpie Alexander G. G. , Cutler Neal R. , Hiatt William R. , Kittelson John M. ,   for the Antithrombotic Trials Leadership and Steering (ATLAS) Group
Published: June 2016

SummaryClinical trials of antithrombotic therapy require a cohesive assessment of benefit and risk. A new graphical method to represent the bivariate relation of benefit and risk in trials of antithrombotic drugs is described and illustrated using published data from the four major registration clinical trials of non-vitamin K oral anticoagulants (NOACs) totalling 71,683 patients for prevention of thromboembolic events (TE) in patients with atrial fibrillation (RE-LY, ROCKET AF, ARISTOTLE, and ENGAGE-AF TIMI48). A curve representing a null hypothesis defines a region of benefit on a two-dimensional plane. Trial results are summarised by a rectangle defined by standard 95 % confidence intervals (CI) for thrombosis and bleeding risks. Benefit is judged by whether the confidence rectangle contains the null curve. The treatment effect is measured by the distance from the null curve to the opposing corners of the confidence rectangle (termed “corner distance (CD)”). Across trials NOACs reduced the absolute risk of TE compared to warfarin by 0.30 % (95 % CI: –0.56 % to –0.05 %) and reduced major bleeding by 0.88 % (95 % CI: –1.26 % to –0.51 %). Bivariate evaluation showed NOAC superiority to warfarin overall and elucidated dose differences; low dose edoxaban increased bivariate TE-bleeding risk 0.08 % (CD = –0.85 % to 0.78 %), whereas high dose edoxaban reduced risk 1.41 % (CD = –2.07 % to –0.70 %). In conclusion, bivariate evaluation facilitates visual assessment of the safety-efficacy profile of antithrombotic drugs. Its application to trials in atrial fibrillation found NOACs superior to warfarin without substantial differences between agents.Supplementary Material to this article is available online at www.thrombosis-online.com.