bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer support needs, preferences and experiences of adults with acquired neurological disability: a scoping review protocol
Authors: Wellecke Cornelia , Douglas Jacinta , Winkler Di , Brown Mark 
Published: October 2024

IntroductionPeer support is a promising adjunct to traditional rehabilitation methods for helping adults with acquired neurological disability adjust to and navigate life with a disability. However, there is limited guidance on how to implement peer support for this cohort. To help inform peer support practices, the aim of this scoping review is to determine what is currently known about the peer support needs, preferences and experiences of adults with acquired neurological disability.Methods and analysisThe scoping review will be conducted according to guidelines published by Arksey and O’Malley, Levacet aland Peterset al. Reporting will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews. Systematic searches on five electronic databases (CINAHL, Embase, MEDLINE, PsycINFO and Scopus) will be conducted to identify peer-reviewed research published since 2013 that investigates any type of peer support for adults (18–65 years) with any acquired neurological disability. Information about the study, participant and peer support characteristics, as well as data pertaining to the key outcomes of interest (ie, needs, preferences and experiences), will be charted, summarised and reported. Qualitative data will be analysed using thematic synthesis, and findings will be discussed with 4–6 people with lived experience of acquired neurological disability.Ethics and disseminationThe review does not require an ethics application. It is anticipated that findings will be disseminated through journal publications and conference presentations. Translation of the findings to non-academic audiences will be informed by the consultation with lived experience experts.
Energy availability and its association with health-related outcomes among national athletes at risk of relative energy deficiency in sports (REDs)
Authors: Marzuki Muhammad Irfan Haiqal , Jamil Nor Aini , Mohamad Mohd Izham , Chai Wen Jin , Farah Nor MF , Safii Nik Shanita , Jasme Jasmiza Khuzairi 
Published: October 2024

BackgroundLow energy availability (LEA) occurs when athletes’ energy intake fails to match the energy expended during exercise, resulting in insufficient energy to support essential functions for optimal health, a condition known as relative energy deficiency in sports (REDs).ObjectiveThis study aims to explore the prevalence of LEA among Malaysian national athletes and its associations with health-related outcomes.MethodsA total of 43 athletes (51.2% males, aged 18–40) identified previously as having moderate or high risk of REDs through a questionnaire underwent comprehensive clinical assessments. Resting metabolic rate (RMR) was measured using indirect calorimetry, with an RMR ratio of <0.90 indicating LEA. Weight and height were measured, and fasting blood samples were analysed for ferritin, free triiodothyronine (fT3), follicle-stimulating hormone (FSH), luteinising hormone (LH), estradiol (female athletes) and testosterone (male athletes). Bone mineral density (BMD) of the lumbar spine and total left hip, as well as body composition, were measured using dual-energy X-ray absorptiometry (DXA).ResultsOut of the 43 athletes, 12 showed evidence of LEA, exhibiting at least one of the following characteristics: low estradiol levels (87.5%), low testosterone (75.0%), low fT3 (66.7%), low LH (58.3%), low FSH (58.3%), low ferritin (25.0%) and low BMD (8.3%). Notably, fT3, estradiol and testosterone were significant predictors for LEA.ConclusionsA low but noteworthy incidence of LEA among Malaysian national athletes was associated with hormone imbalances. Awareness about LEA among athletes and sports personnel is essential for early detection and appropriate intervention.
Establishment of enterically transmitted hepatitis virus animal models using lipid nanoparticle-based full-length viral genome RNA delivery system
Authors: Liu Tianxu , Li Jian , Yin Xin , Lu Fengmin , Zhao Hui , Wang Lin , Qin Cheng-Feng 
Published: October 2024

BackgroundEnterically transmitted hepatitis viruses, such as hepatitis A virus (HAV) and hepatitis E virus (HEV), remain notable threats to public health. However, stable and reliable animal models of HAV and HEV infection are lacking.ObjectiveThis study aimed to establish HAV and HEV infections in multiple small animals by intravenously injecting lipid nanoparticle (LNP)-encapsulated full-length viral RNAs (LNP-vRNA).DesignIn vitro transcribed and capped full-length HAV RNA was encapsulated into LNP and was intravenously inoculated toIfnar−/− mice, and HEV RNA to rabbits and gerbils. Virological parameters were determined by RT-qPCR, ELISA and immunohistochemistry. Liver histopathological changes were analysed by H&E staining. Antiviral drug and vaccine efficacy were further evaluated by using the LNP-vRNA-based animal model.ResultsOn intravenous injection of LNP-vRNA, stable viral shedding was detected in the faeces and infectious HAV or HEV was recovered from the livers of the inoculated animals. Liver damage was observed in LNP-vRNA (HAV)-injected mice and LNP-vRNA (HEV)-injected rabbits. Mongolian gerbils were also susceptible to LNP-vRNA (HEV) injections. Finally, the antiviral countermeasures and in vivo function of HEV genome deletions were validated in the LNP-vRNA-based animal model.ConclusionThis stable and standardised LNP-vRNA-based animal model provides a powerful platform to investigate the pathogenesis and evaluate countermeasures for enterically transmitted hepatitis viruses and can be further expanded to other viruses that are not easily cultured in vitro or in vivo.
Long-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis
Authors: Odanović Natalija , Schwann Alexandra N , Zhang Zhiyuan , Kapadia Sohum S , Kunnirickal Steffne J , Parise Helen , Tirziu Daniela , Ilic Ivan , Lansky Alexandra J , Pietras Cody G , Shah Samit M 
Published: October 2024

BackgroundThe prognosis of myocardial ischaemia with no obstructive coronary artery disease (INOCA) and its underlying vasomotor disorders, vasospastic angina (VSA) and microvascular angina (MVA), is not well defined. The aim of this study was to perform a systematic review and meta-analysis of studies evaluating the long-term prognosis of patients with INOCA.MethodsWe included studies evaluating the prognosis of patients with INOCA published between January 1984 and August 2023 in Medline, Embase, Web of Science and Cochrane databases. Studies were selected if they included patients who fulfilled the Coronary Vasomotor Disorders International Study Group (COVADIS) criteria for either possible or definitive VSA or MVA. The primary outcomes were composite of all-cause death and myocardial infarction (MI), and major adverse cardiovascular event (MACE) at annual intervals up to 5-year follow-up. The incidence of primary outcomes for INOCA, each INOCA endotype and by method used to determine the diagnosis was calculated using the random effects model.ResultsFifty-four studies (17 302 patients) meeting the eligibility criteria were selected. The rate of all-cause death and MI with VSA was 0.7 (95% CI 0.4 to 1.0)/100 patient-years and with MVA was 1.1 (95% CI 0.7 to 1.5)/100 patient-years (p>0.05). The rate of MACE with VSA was 1.1 (95% CI 0.5 to 1.9)/100 patient-years and with MVA was 2.5 (95% CI 1.6 to 3.6)/100 patient-years (p=0.025). Patients with reduced coronary flow reserve (CFR) had higher all-cause death and MI rates than patients whose diagnosis of MVA was established based on an abnormal exercise or imaging stress test (4.7 (95% CI 2.0 to 8.4) vs 0.5 (95% CI 0.1 to 1.1) vs 1.1 (95% CI 0.5 to 2.0)/100 patient-years, p=0.001).ConclusionsOverall, patients with INOCA have a low rate of MACEs, but patients with MVA, especially those with reduced CFR, have a significantly higher rate of MACE than other subgroups, although there is high heterogeneity among the included studies.PROSPERO registration numberCRD42021275070.
Use of artificial intelligence-powered ECG to differentiate between cardiac and pulmonary pathologies in patients with acute dyspnoea in the emergency department
Authors: Jang Ji-Hun , Lee Sang-Won , Kim Dae-Young , Shin Sung-Hee , Lee Sang-Chul , Kim Dae-Hyeok , Choi Wonik , Baek Yong-Soo 
Published: October 2024

BackgroundAcute dyspnoea is common in acute care settings. However, identifying the origin of dyspnoea in the emergency department (ED) is often challenging. We aimed to investigate whether our artificial intelligence (AI)-powered ECG analysis reliably distinguishes between the causes of dyspnoea and evaluate its potential as a clinical triage tool for comparing conventional heart failure diagnostic processes using natriuretic peptides.MethodsA retrospective analysis was conducted using an AI-based ECG algorithm on patients ≥18 years old presenting with dyspnoea at the ED from February 2006 to September 2023. Patients were categorised into cardiac or pulmonary origin groups based on initial admission. The performance of an AI-ECG using a transformer neural network algorithm was assessed to analyse standard 12-lead ECGs for accuracy, sensitivity, specificity and area under the receiver operating characteristic curve (AUC). Additionally, we compared the diagnostic efficacy of AI-ECG models with N-terminal probrain natriuretic peptide (NT-proBNP) levels to identify cardiac origins.ResultsAmong the 3105 patients included in the study, 1197 had cardiac-origin dyspnoea. The AI-ECG model demonstrated an AUC of 0.938 and 88.1% accuracy for cardiac-origin dyspnoea. The sensitivity, specificity and positive and negative predictive values were 93.0%, 79.5%, 89.0% and 86.4%, respectively. The F1 score was 0.828. AI-ECG demonstrated superior diagnostic performance in identifying cardiac-origin dyspnoea compared with NT-proBNP. True cardiac origin was confirmed in 96 patients in a sensitivity analysis of 129 patients with a high probability of cardiac origin initially misdiagnosed as pulmonary origin predicted by AI-ECG.ConclusionsAI-ECG demonstrated superior diagnostic accuracy over NT-proBNP and showed promise as a clinical triage tool. It is a potentially valuable tool for identifying the origin of dyspnoea in emergency settings and supporting decision-making.
Assembly and comparative analysis of the complete mitochondrial genome of tea-scented China rose
Authors: Cheng Peilei , Yan Taotao , Cheng Wenhui , Chen Haoyuan , Wang He , Huang Changbing 
Published: October 2024

Plant mitochondrial (mt) genomes enable better understanding of cellular processes and phylogenetic relationships. Tea-scented China rose ‘Hume's Blush Tea-scented China’ is the ancestor of the modern hybrid tea rose and has had an important and lasting influence on the breeding of the modern horticultural rose, but a comprehensive description of its mt genome is not yet available. In this study, mature leaves were used to determine the sequence of the rose mt genome. The mt genome of ‘Hume's Blush Tea-scented China’ is a circular sequence 277 730 bp in length and includes 30 protein-coding genes, 19 tRNA genes, and 3 rRNA genes. We analyzed repeat sequences, codon preferences, and RNA editing processes. In addition, we detected the transfer of 25 chloroplast genes to the mt genome, indicating intracellular genes transferred frequently from chloroplasts to mitochondria in ‘Hume's Blush Tea-scented China’. The phylogenetic analysis of the ‘Hume's Blush Tea-scented China’ mt genome and those of 26 other plant groups reflects its taxonomic status. The Ka/Ks of most genes was less than 1, indicating that most coding genes underwent negative selection, while pi was greater than 0.01, confirming highly diverse genetic variation. This work lays a foundation for future investigation of genetic variation in ‘Hume's Blush Tea-scented China’.
Cost-Effectiveness of Clomiphene Citrate-Based Minimal Stimulation Compared with Controlled Ovarian Stimulation Protocol in Women with Diminished Ovarian Reserve
Authors: Nishii Shogo , Akino Ryosuke , Chen Linji , Nishioka Nana , Nakabayashi Hiroki , Tabuchi Akihiko , Sakamoto Miwa , Kondo Tetsuro , Sekizawa Akihiko 
Published: October 2024

Background: In Japan, where infertility treatment is now covered by insurance, appropriate protocols for patients with diminished ovarian reserve (DOR) based on treatment outcomes and cost-effectiveness must be selected. Therefore, this study aims to provide information on the outcomes and cost-effectiveness of conventional ovarian stimulation and mild stimulation for patients with DOR in Japan. Methods: Data from 66 women who underwent first oocyte retrieval at Showa University Hospital between May 2019 and November 2023 were analyzed. Results: The clomiphene citrate (CC) group used significantly fewer gonadotropins and incurred lower costs than the conventional ovarian stimulation group while achieving comparable clinical outcomes, including cumulative live birth rates. Conclusions: CC-based minimal stimulation is a cost-effective alternative to conventional ovarian stimulation for patients with low ovarian reserve without compromising clinical efficacy. Further randomized controlled trials are required to confirm these findings and optimize protocols for this population.
Drug‐Induced Intracranial Pressure Increase: Disproportionality Analysis of the Public Version of the FDA Event Reporting System
Authors: Xu Caibing , Zhang Jinghua , Zhang Yuxia , Sun Qiuyan , Yang Xuedong , Fang Wei 
Published: October 2024

Objective: This study is aimed at identifying the most common drugs associated with the risk of intracranial pressure increase (IPI) based on the US Food and Drug Administration Adverse Event Reporting System (FAERS) database.Methods: OpenVigil 2.1 was used to query the FAERS database and data from the first quarter of 2004 to the third quarter of 2022 were retrieved. Pharmacovigilance tools were employed for the quantitative detection of signals, where a signal represents a drug‐induced adverse event, including the reporting odds ratio (ROR > 1 with 95% confidence interval, the reports number ≥ 2) and proportional reporting ratio (PRR > 2, χ2 ≥ 4).Results: Among the 12,060,031 adverse event reports, there were 3113 cases in which drugs were the primary suspect cause of IPI. Drug‐induced intracranial pressure increase (DIPI) was more often observed in young females. The Top 5 drugs with the highest ROR and PRR were minocycline, doxycycline, acetazolamide, somatropin recombinant, and cytarabine.Conclusion: Potential risks of DIPI should be closely monitored in clinical practice. Our study is consistent with clinical observations, which call for further research to establish the basis of these drugs and IPI.
Supplementary Table 5 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Authors: Ishida Chiaki T. , Myers Stephanie L. , Kubota Casie S. , Shao Wei , McGuire Meredith R. , Liu Chune , Ewachiw Theodore E. , Mukhopadhyay Debaditya , Ke Suqi , Wang Hao , Rasheed Zeshaan A. , Anders Robert A. , Espenshade Peter J. 
Published: October 2024

<p>Table S5. SREBP target genes analyzed using the Kaplan-Meier Plotter </p>
Evolution in Linguistics – Conceptual Innovation, Metonymy, and Miscommunication
Authors: Verhagen Arie 
Published: October 2024

Abstract
Conceptual innovations in science (‘paradigm shifts’ in the sense of Kuhn) come with changes in the meaning of basic terminology in that field. Linguistics is no exception. But linguistics is in the peculiar position that it comprises the study of the meaning of linguistic items, and the way these meanings change. Some basic ideas of cognitive semantics, especially the concept of metonymy, shed light on the risk of miscommunication in a scientific field in a period of innovation. Paradoxically, these risks are instantiated in a controversy in the field of linguistics itself that was triggered by the then new, Darwinian understanding of evolution. The paper ends by exploring a recent theoretical innovation (the ‘usage-based’ approach, especially its most recent variants) that holds a promise for overcoming the controversies, provided theoretical linguists accept that terminology also in their own field is to be semantically more precise than in everyday language use.
Rethinking the Relationship between Subjectification, Intersubjectification, and Textualization from a Constructionalist Perspective
Authors: Traugott Elizabeth Closs 
Published: October 2024

Abstract
In the last forty years there have been several proposals regarding a generalizable historical ordering among subjectification, intersubjectification and textualization. To date, most hypotheses have been developed within the framework of grammaticalization, in which hypotheses about unidirectional paths of change have played a significant role. In this paper I ask two questions: 1: Is there evidence for a generalizable historical ordering among subjectification, intersubjectification and textualization? 2. What hypotheses about the relationship between these three change-types appear to be optimal from the perspective of Diachronic Construction Grammar? I argue that, although particular data may suggest one trajectory or another, it is not possible to generalize over the order of changes. I propose a constructionalist model in which constructions have communicative, among other, functions, and in which the properties subjective, intersubjective and textual are of equal status and may emerge simultaneously in certain domains of grammar, such as Discourse Structuring Markers.
Northern Hemisphere Atmospheric Blocking in CMIP6 Climate Projections Using a Hybrid Index
Authors: Lohmann Richard , Purr Christopher , Ahrens Bodo 
Published: October 2024

Abstract
Atmospheric blocking is quantified by a variety of different blocking indices. Here, the index by Davini et al. (DAV12) is modified to a hybrid index by additionally considering the extent of the blocking anticyclone. Applying both indices, the DAV12 and the hybrid index, to the twentieth-century reanalyses, the ERA-20C and the 20CRv3 (hereafter 20CR) ensemble reveals large differences between the reanalyses. The annual blocking frequency increases widespread and significantly in ERA-20C, but only regionally and nonsignificantly in the 20CR ensemble mean. Trend analysis reveals higher reliability of the 20CR ensemble mean than ERA-20C blocking results. Seasonally, the changes in summer blocking are most pronounced and significantly positive around Greenland. The CMIP6-mean historical climate simulation agrees well in magnitude with 20CR during the period 1900–2014, with some underestimation of blocking frequency in the last decades related to inconsistent trends. For a future climate, the average of the CMIP6 models projects a decrease in blocking frequency in major parts of the Northern Hemisphere in summer and in winter. A CMIP6 subset of models which agree best with reanalyses shows a less negative future trend. Because of the mismatch of historical trends, especially in summer, the future projections are uncertain.
Comparing the Atmospheric Responses to Reduced Arctic Sea Ice, a Warmer Ocean, and Increased CO2 and Their Contributions to Projected Change at 2°C Global Warming
Authors: Yu Hao , Screen James A. , Xu Mian , Hay Stephanie , Catto Jennifer L. 
Published: October 2024

Abstract
We consider the combined and individual influences of Arctic sea ice loss, sea surface temperature (SST) warming, and the direct radiative effect of increased CO2 on the Northern Hemispheric climate. The surface climate (e.g., temperature and precipitation) and atmospheric circulation responses (e.g., sea level pressure and wind) to these drivers are quantified using simulations from the Polar Amplification Model Intercomparison Project (for sea ice loss and SST warming) and the Cloud Feedback Model Intercomparison Project (for increased CO2). We verify the linear additivity of the PAMIP-derived winter responses to sea ice loss and SST change. The responses to SST change are of greater magnitude than that due to sea ice loss or due to CO2 direct radiative forcing in most seasons and regions, excluding the Arctic. Notably, however, sea ice loss is at least as important as SST change for the winter atmospheric circulation response over the North Atlantic and Siberia. The dynamical responses to sea ice loss and SST change oppose each other in many regions in winter, while the responses to SST and CO2 direct radiative forcing are often opposing in summer. Such opposing responses are less evident for the thermodynamical response. The sum of all three responses reproduces well the spatial patterns of change at 2°C global warming in winter and autumn in phase 6 of the Coupled Model Intercomparison Project projections but overestimates their magnitude.
The Effect of Southern Ocean Topography on the Global MOC and Abyssal Water Mass Distribution
Authors: Monkman Tatsu , Jansen Malte F. 
Published: October 2024

Abstract
We investigate the role of Southern Ocean topography and wind stress in the deep and abyssal ocean overturning and water mass composition using a suite of idealized global ocean circulation models. Specifically, we address how the presence of a meridional ridge in the vicinity of Drake Passage and the formation of an associated Southern Ocean gyre influence the water mass composition of the abyssal cell. Our experiments are carried out using a numerical representation of the global ocean circulation in an idealized two-basin geometry under varying wind stress and Drake Passage ridge height. In the presence of a low Drake Passage ridge, the overall strength of the meridional overturning circulation is primarily influenced by wind stress, with a topographically induced weakening of the middepth cell and concurrent strengthening of the abyssal cell occurring only after ridge height passes 2500 m. Passive tracer experiments show that a strengthening middepth cell leads to increased abyssal ventilation by North Atlantic water masses, as more North Atlantic Deep Water (NADW) enters the Southern Ocean and then spreads into the Indo-Pacific. We repeat our tracer experiments without restoring in the high-latitude Southern Ocean in order to identify the origin of water masses that circulate through the Southern Ocean before sinking into the abyss as Antarctic Bottom Water. Our results from these “exchange” tracer experiments show that an increasing ridge height in Drake Passage and the concurrent gyre spinup lead to substantially decreased NADW-origin waters in the abyssal ocean, as more surface waters from north of the Antarctic Circumpolar Current (ACC) are transferred into the Antarctic Bottom Water formation region.

Significance Statement
The objective of this study is to investigate how topographic features in the Southern Ocean can affect the overall structure of Earth’s large-scale ocean circulation and the distribution of water masses in the abyssal ocean. We focus on the Southern Ocean because the region is of central importance for exchange between the Atlantic and Indo-Pacific Ocean basins and for CO2 and heat uptake into the abyssal ocean. Our results indicate that Southern Ocean topography plays a major role in the overall circulation by 1) controlling the direct transfer of abyssal waters from the Atlantic to the Indo-Pacific via its influence on the Atlantic meridional overturning circulation and 2) controlling the coupling between the abyssal ocean and surface waters north of the Antarctic Circumpolar Current via the Southern Ocean gyre.