bluuebunny/crossref_metadata_2025_split huggingface dataset:
Proof of 5D An AGT conjecture at β = 1
Authors: Shen Qian , Huang Zi-Hao , Hu Shao-Ping , Yuan Qing-Jie , Zhang Kilar 
Published: September 2024

Abstract
In this paper, we give a proof of 5D An AGT conjecture at β = 1, where the gauge theory side is one dimension higher than the original 4D case, and corresponds to the q-deformation of the 2D conformal field theory side. We define a q-deformed An Selberg integral, which generalizes the An Selberg integral and the q-deformed A1 Selberg integral in the literature. A q-deformed An Selberg average formula with n + 1 Schur polynomials is proposed and proved to complete the proof.
Unveiling desert region in inert doublet model assisted by Peccei-Quinn symmetry
Authors: Ghosh Anupam , Konar Partha 
Published: September 2024

Abstract
The Inert Higgs Doublet model (IDM), assisted by Peccei-Quinn (PQ) symmetry, offers a simple but natural framework of a dark sector that accommodates Weakly Interacting Massive Particle (WIMP) and axion as dark matter components. Spontaneous breaking of U(1)PQ symmetry, which was originally proposed as an elegant solution to the strong charge-parity (CP) problem, also ensures the stability of WIMP through a residual ℤ2 symmetry. Interestingly, additional fields necessitated by PQ symmetry further enrich the dark sector. These include a scalar field proprietor for axion DM and a vector-like quark (VLQ) that acts as a portal for the dark sector through Yukawa interactions. Moreover, this combination of the axion and WIMP components satisfies the observed DM relic density and reopens the phenomenologically exciting region of the IDM parameter space where the WIMP mass falls between 100 - 550 GeV. We investigate the model-independent pair production of VLQs exploring this region at the Large Hadron Collider (LHC), incorporating the effects of next-to-leading order (NLO) QCD corrections. After production, each VLQ decays into a top or bottom quark accompanied by an inert scalar, a consequence of the residual ℤ2 symmetry. Utilising relevant observables with a leptonic search channel and employing multivariate analysis, we demonstrate the ability of this analysis to exclude a significant portion of the parameter space with an integrated luminosity of 300 fb−1.
On Bethe equations of 2d conformal field theory
Authors: Procházka Tomáš , Watanabe Akimi 
Published: September 2024

Abstract
We study the higher spin algebras of two-dimensional conformal field theory from the perspective of quantum integrability. Starting from Maulik-Okounkov instanton R-matrix and applying the procedure of algebraic Bethe ansatz, we obtain infinite commuting families of Hamiltonians of quantum ILW hierarchy parametrized by the shape of the auxiliary torus. We calculate explicitly the first five of these Hamiltonians. Then, we numerically verify that their joint spectrum can be parametriezed by solutions of Litvinov’s Bethe ansatz equations and we conjecture a general formula for the joint spectrum of all ILW Hamiltonians, based on results of Feigin, Jimbo, Miwa and Mukhin.There are two interesting degeneration limits, the infinitely thick and the infinitely thin auxiliary torus. In one of these limits, the ILW hierarchy degenerates to Yangian or Benjamin-Ono hiearchy and the Bethe equations can be easily solved. The other limit is singular but we can nevertheless extract local Hamiltonians corresponding to quantum KdV or KP hierarchy. Litvinov’s Bethe equations in this local limit provide an alternative to Bethe ansatz equations of Bazhanov, Lukyanov and Zamolodchikov, but are more transparent, work at any rank and are manifestly symmetric under triality symmetry of $$ \mathcal{W} $$
W
1+∞. Finally, we illustrate analytic properties of the solutions of Bethe equations in minimal models, in particular for Lee-Yang CFT. The analytic structure of Bethe roots is very rich as it captures the representation theory of $$ \mathcal{W} $$
W
N minimal models.
Spherical Logvinenko–Sereda–Kovrijkine type inequality and null-controllability of the heat equation on the sphere
Authors: Dicke Alexander , Veselić Ivan 
Published: September 2024

AbstractIt is shown that the restriction of a polynomial to a sphere satisfies a Logvinenko–Sereda–Kovrijkine type inequality (a specific type of uncertainty relation). This implies a spectral inequality for the Laplace–Beltrami operator, which, in turn, yields observability and null-controllability with explicit estimates on the control costs for the spherical heat equation that are sharp in the large and in the small time regime.
A naturally occurring 22-amino acid fragment of human hemoglobin A inhibits autophagy and HIV-1
Authors: Freisem Dennis , Rodriguez-Alfonso Armando A. , Lawrenz Jan , Zhou Zhixuan , Monecke Thomas , Preising Nico , Endres Sascha , Wiese Sebastian , Ständker Ludger , Kuan Seah-Ling , Thal Dietmar R. , Weil Tanja , Niessing Dierk , Barth Holger , Kirchhoff Frank , Harms Mirja , Münch Jan , Sparrer Konstantin M. J. 
Published: September 2024

AbstractAutophagy is an evolutionarily ancient catabolic pathway and has recently emerged as an integral part of the innate immune system. While the core machinery of autophagy is well defined, the physiological regulation of autophagy is less understood. Here, we identify a C-terminal fragment of human hemoglobin A (HBA1, amino acids 111–132) in human bone marrow as a fast-acting non-inflammatory inhibitor of autophagy initiation. It is proteolytically released from full-length HBA1 by cathepsin E, trypsin or pepsin. Biochemical characterization revealed that HBA1(111–132) has an in vitro stability of 52 min in human plasma and adopts a flexible monomeric conformation in solution. Structure–activity relationship studies revealed that the C-terminal 13 amino acids of HBA1(120–132) are sufficient to inhibit autophagy, two charged amino acids (D127, K128) mediate solubility, and two serines (S125, S132) are required for function. Successful viruses like human immunodeficiency virus 1 (HIV-1) evolved strategies to subvert autophagy for virion production. Our results show that HBA1(120–132) reduced virus yields of lab-adapted and primary HIV-1. Summarizing, our data identifies naturally occurring HBA1(111–132) as a physiological, non-inflammatory antagonist of autophagy. Optimized derivatives of HBA1(111–132) may offer perspectives to restrict autophagy-dependent viruses.
The effect of targeting both quantitative and qualitative objectives in generative design tools on the design outcomes
Authors: Saadi Jana I. , Chong Leah , Yang Maria C. 
Published: September 2024

AbstractCurrent generative design tools backed by artificial intelligence (AI) primarily allow for quantitative inputs while qualitative aspects of a design, in particular aesthetics, have been shown to be considered indirectly by designers. To explore this further, controlled lab experiments were conducted to understand how designers incorporate quantitative and qualitative objectives while using generative design tools and how their behavior may affect design performance. Thirty-four participants completed a design task with quantitative and qualitative objectives with and without generative design tools. The outcomes produced using generative design tools displayed a greater aesthetic diversity and expanded a larger portion of the objective space compared to those without using a generative design tool. Participants also expressed the ability to focus on the qualitative objectives by delegating the quantitative objective to the generative design tool. This showcases the potential for high-performing generative design tools to assist human designers by alleviating part of their cognitive load when balancing multiple objectives, giving them the bandwidth to focus on other objectives not fully incorporated by the tool. In this way, leveraging the expertise of both the human designer and the generative design tool can allow for greater consideration of various objectives throughout the design process.
The Adams isomorphism revisited
Authors: Cnossen Bastiaan , Lenz Tobias , Linskens Sil 
Published: September 2024

AbstractWe establish abstract Adams isomorphisms in an arbitrary equivariantly presentable equivariantly semiadditive global category. This encompasses the well-known Adams isomorphism in equivariant stable homotopy theory, and applies more generally in the settings of G-Mackey functors, G-global homotopy theory, and equivariant Kasparov categories.
Reliability of Chest Wall Perforator Flaps for Breast Reshaping following Massive Weight Loss
Authors: Hammad Mai Raafat Abdelazim , Badawy Mohamed Samir , Naguib Eman Nagy , Mabrouk Amr 
Published: September 2024

Abstract

Background
Breast deformity following massive weight loss poses a unique challenge inadequately managed by traditional methods. Patients also have considerable lateral and posterior upper trunk tissue surplus.
Multiple studies have used chest wall flaps for auto-augmentation with mastopexy to tackle this problem. However, the outcome measures did not include any objective tools to assess the reliability of these flaps. Hence, in this study sono-mammography and breast anthropometric measurements are used for evaluation of the added volume and long-term sustainability of chest wall perforator flaps.

Methodology
Twenty massive weight loss patients with Pittsburgh Rating Scale score 2-3 underwent mastopexy with autologous augmentation through perforator flaps encompassing lateral chest wall skin. Outcome measures were breast volume, and the presence of fat necrosis on mammography, and direct breast anthropometry.

Conclusion
All patients showed a consistent increase in volume postoperatively and no fat necrosis in postoperative mammography, reflecting flap reliability over one year of follow-up. All postoperative anthropometric measurements showed improvement in the breast deformities addressed.

Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
ESR Essentials: imaging of suspected child abuse—practice recommendations by the European Society of Paediatric Radiology
Authors: Colleran Gabrielle C. , Fossmark Maria , Rosendahl Karen , Argyropoulou Maria , Mankad Kshitij , Offiah Amaka C. 
Published: September 2024

Abstract
The goal of this paper is to provide a useful desktop reference for the imaging of suspected child abuse with clear, age-specific pathways for appropriate evidence-based imaging and follow-up.
We aim to provide a road map for the imaging evaluation and follow-up of this important and vulnerable cohort of patients presenting with signs and symptoms concerning for inflicted injury. As the imaging recommendations differ for children of different ages, we provide a flowchart of the appropriate imaging pathway for infants, toddlers, and older children, which allows ease of selection of which children should undergo skeletal survey, non-contrast computed tomography (CT) brain with 3-dimensional (D) reformats, and magnetic resonance imaging (MRI) of the brain and whole spine. For ease of review, we include a table of the common intracranial and spinal patterns of injury in abusive head trauma. We summarise search patterns, areas of review, and key findings to include in the report.
To exclude skeletal injury, infants and children under 2 years of age should undergo a full skeletal survey in accordance with national guidelines, with a limited follow-up skeletal survey performed 11–14 days later. For children over 2 years of age, the need for skeletal imaging should be decided on a case-by-case basis.
All infants should undergo a non-contrast-enhanced CT brain with 3-D reformats. If this is normal with no abnormal neurology, then no further neuroimaging is required. If this is abnormal, then they should proceed to MRI brain and whole spine within 2–5 days. Children older than 1 year of age who have abnormal neurology and/or findings on skeletal survey that are suggestive of inflicted injury should undergo non-contrast CT brain with 3-D reformats and, depending on the findings, may also require MRI of the brain and whole spine.
We hope that this will be a helpful contribution to the radiology literature, particularly for the general radiologist with low volumes of paediatrics in their practice, supporting them with managing these important cases when they arise in daily practice.

Key Points

The choice of initial imaging (skeletal survey and/or brain CT) depends on the age of the child in whom abuse is suspected.

A follow-up skeletal survey is mandatory 11–14 days after the initial survey.

If an MRI of the brain is performed, then an MRI of the whole spine should be performed concurrently.
Spatial structuring of coral traits along a subtropical-temperate transition zone persists despite localised signs of tropicalisation
Authors: Sahin Defne , E. Bosch Nestor , Cooper Chenae , Filbee-Dexter Karen , Radford Ben , Schoepf Verena , Thomson Damian P. , Wernberg Thomas 
Published: September 2024

AbstractClimate-driven species range expansions are underway with more tropically affiliated species, including Scleractinian corals, becoming increasingly abundant at higher latitudes. However, uncertainty remains on how these range shifts will affect reef-scale ecosystem processes, which will ultimately depend on the traits of the taxa that dominate these assemblages. Here, we quantified spatiotemporal patterns in the taxonomic and trait structure of coral assemblages along the subtropical-temperate coast of Western Australia (27°–34°S). Coral abundance was generally low and coral cover < 5% across our study sites. Coral assemblages shared similarities in morphological trait structures across the latitudinal gradient, mostly characterised by taxa with simple morphologies; yet subtle differences were also observed across latitudes, with high-latitude corals characterised by slower growth rates and reduced maximum colony sizes. We found a 3.4-fold increase (from 1 to 3.4 individuals m−2) in coral abundance at one heavily disturbed location, where canopy-forming seaweeds were replaced by turfing algae, a pattern that was partly driven by an increase in the relative contribution of warm affinity taxa, such as Acropora spp. We predicted these changes would be reflected in different components of functional diversity; yet, despite a localised signal of tropicalisation, we only observed subtle changes in the functional identity, richness, evenness, and divergence. The spatially invariant trait structure of coral assemblages suggests that the nature of ecosystem functions will likely remain unchanged during early stages of tropicalisation, and hence their contribution to temperate reef-scale ecological processes will depend on dominance over other benthic foundational species.
Utility guideline and considerations for the novel Hugo™ RAS (robotic-assisted surgery) system in colorectal surgery: surgical outcomes and initial experience in a tertiary center
Authors: Arroyo Antonio , Sánchez-Romero Ana , Soler-Silva Álvaro , Quinto Saray , López-Rodríguez-Arias Francisco , Alcaide María-José , Serrano-Navidad Mónica , Miranda Elena , Muñoz José-Luis , Sánchez-Guillén Luis 
Published: September 2024

Abstract
Purpose
A novel robotic platform—Hugo™ RAS (robotic-assisted surgery) system—has been introduced with several innovations that may prove advantageous for surgeons, such as an open console and four interchangeable modular arms. Our study aims to evaluate this platform’s safety, efficacy, and potential impact on the surgical treatment of colorectal pathology.

Methods
Patients underwent robotic-assisted colorectal procedures with the Hugo™ RAS system at the General University Hospital of Elche from October 2023 to July 2024. Patient characteristics, intraoperative and postoperative variables, and robotic technical issues were recorded.

Results
Forty consecutive patients were included (14 right, 13 left, and 8 rectum neoplasms; 4 left diverticulitis; and 1 ileocecal Crohn’s disease). The patients’ characteristics were as follows: median age, 69.5 years; 24 males and 16 females; 45% ASA III–IV; and Charlson Comorbidity Index > 5:42.5%.
We recorded four medical (2 anemia, 1 phlebitis, and 1 admission to the intensive care unit) and three surgical (1 hematoma of the incision, 1 intestinal occlusion, and 1 dehiscence of the anastomosis) postoperative complications. We had no conversions neither open nor laparoscopic surgery. The average hospital stay was 3 days, with no mortality or readmission.

Conclusions
The Hugo™ RAS system is safe and feasible for colorectal procedures. The modularity of the arms provides the versatility of configurations adjusted depending on the patient’s body features and the surgeon’s preferences and greater adaptability to operating rooms. The open console is highly comfortable and ergonomic for the surgeon, allowing communication with the operating room environment.

Trial registration
NCT06512480
Association of in vivo retention of [18f] flortaucipir pet with tau neuropathology in corresponding brain regions
Authors: Freiburghaus Tove , Pawlik Daria , Oliveira Hauer Kevin , Ossenkoppele Rik , Strandberg Olof , Leuzy Antoine , Rittmo Jonathan , Tremblay Cécilia , Serrano Geidy E. , Pontecorvo Michael J. , Beach Thomas G. , Smith Ruben , Hansson Oskar 
Published: September 2024

Abstract[18F]Flortaucipir is an FDA-approved tau-PET tracer that is increasingly utilized in clinical settings for the diagnosis of Alzheimer’s disease. Still, a large-scale comparison of the in vivo PET uptake to quantitative post-mortem tau pathology and to other co-pathologies is lacking. Here, we examined the correlation between in vivo [18F]flortaucipir PET uptake and quantitative post-mortem tau pathology in corresponding brain regions from the AVID A16 end-of-life study (n = 63). All participants underwent [18F]flortaucipir PET scans prior to death, followed by a detailed post-mortem neuropathological examination using AT8 (tau) immunohistochemistry. Correlations between [18F]flortaucipir standardized uptake value ratios (SUVRs) and AT8 immunohistochemistry were assessed across 18 regions-of-interest (ROIs). To assess [18F]flortaucipir specificity and level of detection for tau pathology, correlations between [18F]flortaucipir SUVR and neuritic plaque score and TDP-43 stage were also computed and retention was further assessed in individuals with possible primary age-related tauopathy (PART), defined as Thal phase ≤ 2 and Braak stage I–IV. We found modest-to-strong correlations between in vivo [18F]flortaucipir SUVR and post-mortem tau pathology density in corresponding brain regions in all neocortical regions analyzed (rho-range = 0.61–0.79, p < 0.0001 for all). The detection threshold of [18F]flortaucipir PET was determined to be 0.85% of surface area affected by tau pathology in a temporal meta-ROI, and 0.15% in a larger cortical meta-ROI. No significant associations were found between [18F]flortaucipir SUVRs and post-mortem tau pathology in individuals with possible PART. Further, there was no correlation observed between [18F]flortaucipir and level of amyloid-β neuritic plaque load (rho-range =  – 0.16–0.12; p = 0.48–0.61) or TDP-43 stage (rho-range =  – 0.10 to  – 0.30; p = 0.18–0.65). In conclusion, our in vivo vs post-mortem study shows that the in vivo [18F]flortaucipir PET signal primarily reflects tau pathology, also at relatively low densities of tau proteinopathy, and does not bind substantially to tau neurites in neuritic plaques or in individuals with PART.
Anatomy-based fitting improves speech perception in noise for cochlear implant recipients with single-sided deafness
Authors: Kurz Anja , Herrmann David , Müller-Graff Franz-Tassilo , Voelker Johannes , Hackenberg Stephan , Rak Kristen 
Published: September 2024

Abstract

Objective
To evaluate objective and subjective hearing outcomes in experienced cochlear implant users with single sided deafness (SSD CI) who used fitting maps created via anatomy-based fitting (ABF) and clinically-based fitting (CBF).

Participants
Twelve SSD CI users with postlingual hearing loss.

Intervention
OTOPLAN (Version 3. (MED-EL) was used to determine intracochlear electrode contact positions using post-operative high-resolution flat panel volume computed tomography. From these positions, the corresponding center frequencies and bandwidths were derived for each channel. These were implemented in the clinical fitting software MAESTRO to yield an ABF map individualized to each user.

Main Outcome Measures
ABF and CBF maps were compared. Objective speech perception in quiet and in noise, binaural effects, and self-perceived sound quality were evaluated.

Results
Significantly higher speech perception in noise scores were observed with the ABF map compared to the CBF map (mean SRT50: -6.49 vs. -4.8 dB SNR for the S0NCI configuration and − 3.85 vs. -2.75 dB SNR for the S0N0 configuration). Summation and squelch effects were significantly increased with the ABF map (0.86 vs. 0.21 dB SNR for summation and 0.85 vs. -0.09 dB SNR for squelch). No improvement in speech perception in quiet or spatial release from masking were observed with the ABF map. A similar level of self-perceived sound quality was reported for each map. Upon the end of the study, all users opted to keep the ABF map. This preference was independent of the angular insertion depth of the electrode array.

Conclusions
Experienced SSD CI users preferred using the ABF map, which gave them significant improvements in binaural hearing and some aspects of speech perception.
Longitudinal associations between depressive symptoms and cell deformability: do glucocorticoids play a role?
Authors: Eder Julian , Kräter Martin , Kirschbaum Clemens , Gao Wei , Wekenborg Magdalena , Penz Marlene , Rothe Nicole , Guck Jochen , Wittwer Lucas Daniel , Walther Andreas 
Published: September 2024

AbstractCell deformability of all major blood cell types is increased in depressive disorders (DD). Furthermore, impaired glucocorticoid secretion is associated with DD, as well as depressive symptoms in general and known to alter cell mechanical properties. Nevertheless, there are no longitudinal studies examining accumulated glucocorticoid output and depressive symptoms regarding cell deformability. The aim of the present study was to investigate, whether depressive symptoms predict cell deformability one year later and whether accumulated hair glucocorticoids mediate this relationship. In 136 individuals (nfemale = 100; Mage = 46.72, SD = 11.28; age range = 20–65), depressive symptoms (PHQ-9) and hair glucocorticoids (cortisol and cortisone) were measured at time point one (T1), while one year later (T2) both depressive symptoms and hair glucocorticoids were reassessed. Additionally, cell deformability of peripheral blood cells was assessed at T2. Depression severity at T1 predicted higher cell deformability in monocytes and lymphocytes at T2. Accumulated hair cortisol and cortisone concentrations from T1 and T2 were not associated with higher cell deformability and further did not mediate the relationship between depressive symptoms and cell deformability. Elevated depressive symptomatology in a population based sample is longitudinally associated with higher immune cell deformability, while long-term integrated glucocorticoid levels seem not to be implicated in the underlying mechanism.