bluuebunny/crossref_metadata_2025_split huggingface dataset:
Zukunft Regionale Versorgung – Forschung, Innovation, Kooperation
Authors: Hoffmann Wolfgang , Neugebauer Edmund 
Published: October 2017

Liebe Kolleginnen und Kollegen, sehr geehrte Damen und Herren,die Versorgungsforschung entwickelt sich derzeit rasch und dynamisch, wir erleben eine Professionalisierung der VersorgungsforscherInnen und gleichzeitig eine wachsende Wahrnehmung unserer Forschung bei den Akteuren des Gesundheitssystems und in der Gesundheitspolitik. Deutschlandweit wurden große Förderprogramme in der Versorgungsforschung ausgeschrieben. Das BMBF stellt insgesamt 50 Millionen Euro für den „Aktionsplan Versorgungsforschung“ bereit, mit denen Pogramme zum Aufbau von Zentren der gesundheitsökonomischen Forschung, Strukturförderung im Bereich Altersforschung, Kooperationsnetze für die Versorgungsforschung und zuletzt der Aufbau forschungsbezogener Register gefördert werden.
Krankheiten am Geruch erkennen
Authors: Schmid Eva C 
Published: October 2017

SummaryJeder Mensch hat einen einzigartigen Körpergeruch. Doch nicht nur starkes Schwitzen, Zigaretten und der Verzehr von Knoblauch können diesen verändern oder zu Atemgeruch (Foetor ex ore) führen. Auch ernsthafte Erkrankungen können sich dahinter verbergen.
Wenn Düfte verblassen
Authors: Welge-Lüssen Antje 
Published: October 2017

SummaryRund 15 % der Bevölkerung leiden an einer verminderten Geruchswahrnehmung. Bei 5 % der Bevölkerung fehlt das Riechvermögen komplett. Eine veränderte Geruchswahrnehmung kann viele Ursachen haben. Sie ist mit erheblichen Einbußen an Lebensqualität verbunden. Es ist wichtig, die Geruchswahrnehmung psychophysisch mittels standardisierter und validierter Tests zu überprüfen, um eine Riechstörung nachzuweisen.
Hyperspectral Imaging and Support Vector Machine: A Powerful Combination to Differentiate Black Cohosh (Actaea racemosa) from Other Cohosh Species
Authors: Tankeu Sidonie , Vermaak Ilze , Chen Weiyang , Sandasi Maxleene , Kamatou Guy , Viljoen Alvaro 
Published: October 2017

Abstract
Actaea racemosa (black cohosh) has a history of traditional use in the treatment of general gynecological problems. However, the plant is known to be vulnerable to adulteration with other cohosh species. This study evaluated the use of shortwave infrared hyperspectral imaging (SWIR-HSI) in tandem with chemometric data analysis as a fast alternative method for the discrimination of four cohosh species (Actaea racemosa, Actaea podocarpa, Actaea pachypoda, Actaea cimicifuga) and 36 commercial products labelled as black cohosh. The raw material and commercial products were analyzed using SWIR-HSI and ultra-high-performance liquid chromatography coupled to mass spectrometry (UHPLC-MS) followed by chemometric modeling. From SWIR-HSI data (920 – 2514 nm), the range containing the discriminating information of the four species was identified as 1204 – 1480 nm using Matlab software. After reduction of the data set range, partial least squares discriminant analysis (PLS-DA) and support vector machine discriminant analysis (SVM-DA) models with coefficients of determination (R2
) of ≥ 0.8 were created. The novel SVM-DA model showed better predictions and was used to predict the commercial product content. Seven out of 36 commercial products were recognized by the SVM-DA model as being true black cohosh while 29 products indicated adulteration. Analysis of the UHPLC-MS data demonstrated that six commercial products could be authentic black cohosh. This was confirmed using the fragmentation patterns of three black cohosh markers (cimiracemoside C; 12-β,21-dihydroxycimigenol-3-O-L-arabinoside; and 24-O-acetylhydroshengmanol-3-O-β-D-xylopyranoside). SWIR-HSI in conjunction with chemometric tools (SVM-DA) could identify 80% adulteration of commercial products labelled as black cohosh.
Aspirates and ejectives in Quechua-influenced Spanish
Authors: Babel Anna M. 
Published: October 2017

AbstractThis article describes the use of aspirates and ejectives in a variety of Spanish with significant Quechua contact influence that is spoken in the Santa Cruz valleys of central Bolivia. Aspirates and ejectives occur primarily on Quechua loanwords, making these ‘intermediate phonological relationships’ (Hall 2013) that are hard to categorize with respect to their status as phonetic vs. phonological features. Results from a small-scale perception and shadowing task show that language users are able to distinguish between these sounds and canonical Spanish consonants in minimal pairs, but that there is variation among speakers in the way these sounds are reproduced. While the use of aspirates and glottal stops in Spanish in contact with Mayan languages has been documented (Michnowicz 2015;Michnowicz and Kagan 2016) previous studies of Andean Spanish phonology have not reported the use of aspirates and ejectives as part of the sound system (Boynton 1981;Cassano 1974;Pyle 1981).
“De camareros a profesores” de ELE
Authors: Bruzos Alberto 
Published: October 2017

Abstracto
Este artículo da cuenta de la mercantilización del español como lengua extranjera (ELE) en España. Empezamos presentando el marco teórico de los estudios sobre la mercantilización del lenguaje y sobre el aparato discursivo en torno al valor económico del español desarrollado en España de los 90, el cual proponemos entender como parte de un dispositivo de promoción internacional del español. A continuación, analizamos la visión del ELE en España como industria de la lengua. En concreto, mostramos que la colaboración entre instituciones públicas y entidades privadas ha conformado el sector como turismo idiomático, lo cual tiene consecuencias ideológicas (estandarización y mercantilización de la lengua) y profesionales (falta de legitimidad, precariedad laboral). Concluimos planteando una serie de cuestiones fundamentales para una visión crítica del ELE que contemple la enseñanza de español en relación con la injerencia institucional (política lingüística), las condiciones del mercado laboral, la relación entre conocimiento e interés y otras cuestiones sociales y políticas.
Orthographic and phonological neighborhood databases across multiple languages
Authors: Marian Viorica 
Published: October 2017

Abstract
The increased globalization of science and technology and the growing number of bilinguals and multilinguals in the world have made research with multiple languages a mainstay for scholars who study human function and especially those who focus on language, cognition, and the brain. Such research can benefit from large-scale databases and online resources that describe and measure lexical, phonological, orthographic, and semantic information. The present paper discusses currently-available resources and underscores the need for tools that enable measurements both within and across multiple languages. A general review of language databases is followed by a targeted introduction to databases of orthographic and phonological neighborhoods. A specific focus on CLEARPOND illustrates how databases can be used to assess and compare neighborhood information across languages, to develop research materials, and to provide insight into broad questions about language. As an example of how using large-scale databases can answer questions about language, a closer look at neighborhood effects on lexical access reveals that not only orthographic, but also phonological neighborhoods can influence visual lexical access both within and across languages. We conclude that capitalizing upon large-scale linguistic databases can advance, refine, and accelerate scientific discoveries about the human linguistic capacity.
Chronic non-communicable diseases in low- and middle-income countries: concepts and strategies for prevention, control and advocacy.
Authors: Aikins A. de G. , Agyemang C. 
Published: October 2017

Abstract
Low- and middle-income countries (LMICs) of Africa, Asia and Latin America bear a significant proportion of the global burden of chronic non-communicable diseases (NCDs). LMICs are unable to respond appropriately to their NCD burden because of a complex blend of epidemiological, demographic, health systems, economic, political and structural challenges. There is an urgent need for LMICs to develop practical, culturally appropriate and cost-effective NCD interventions that lower risk at population levels and reduce levels of morbidity and mortality among individuals living with the major NCDs. Countries that have developed practical and sustainable interventions, despite complex resource challenges, offer important models for others to follow. In this paper, we review the evidence on existing interventions, using the World Health Organization (WHO) health systems building blocks model as an analytical framework. We outline interventions that work at community and national levels in 33 countries. We identify three major cross-cutting challenges facing NCD care in these LMICs and consider how the challenges may be addressed drawing on existing best practice responses.
Decline in the Half‐Pounder Life History among Trinity River, California, Steelhead
Authors: Peterson Matthew L. , Hankin David G. , Manishin Kaitlyn 
Published: October 2017

AbstractSteelhead Oncorhynchus mykiss exhibit substantial life history variation throughout their range, but the “half‐pounder” life history is limited to several rivers in northern California and southern Oregon. Half‐pounders first return to freshwater as immature fish after spending just 3–5 months at sea and support valuable freshwater fisheries. In the main‐stem Klamath and Rogue rivers, historically and at present, half‐pounder expression rates were and remain high for fall‐run steelhead. We used visual classifications of the half‐pounder life history from scales collected from the Trinity River to estimate half‐pounder expression rates and investigate the role of size and age prior to ocean entry on the probability that adult steelhead expressed the half‐pounder life history. Half‐pounder expression rates among both wild and hatchery steelhead in the Trinity River have substantially declined since 1982. Among the most common age‐2 wild smolt type, 71% of adults returning in 1982 had previously made a half‐pounder run, whereas estimated rates for adults returning in various years from 1994 to 2013 averaged just 10% (range = 2–25%). Estimated returns of half‐pounders and adults from Trinity River Hatchery releases made prior to 1982 are consistent with a historically high half‐pounder expression rate. Among age‐1 hatchery steelhead smolts, a similar decline seems evident and seems in part related to a large increase in size at release in 1992. Strong negative associations were found between the size prior to ocean entry (wild and hatchery fish) and smolt age (wild fish) and the probability that an individual steelhead expressed the half‐pounder trait; smaller‐sized and younger smolts were more likely to express the trait. Further research focusing on the heritability of this life history trait should be conducted to develop strategies intended to prevent further loss of this unique life history among Trinity River fall‐run steelhead.
MgFe2O4 thin films for detection of ethanol and acetone vapours
Authors: Nagarajan V. , Thayumanavan A. 
Published: October 2017

Spinel MgFe2O4 thin films are prepared with the spray pyrolysis technique. The morphological study shows sand-like crystallites on the film with porosity. The structural study substantiates the polycrystalline nature of the synthesised MgFe2O4 films, which possess a spinel structure. The crystallite size is found to be 25–45 nm in size, which is noted from the morphological study. The energy dispersive X-ray analysis (EDAX) reveals the existence of iron, oxygen and magnesium in MgFe2O4 film. The electrical resistance of MgFe2O4 decreases rapidly when the film is exposed towards acetone and ethanol vapours. The synthesised MgFe2O4 is highly sensitive to acetone vapour at 323 K. The selectivity, sensitivity, recovery time, stability and response time of MgFe2O4 film to acetone and ethanol sensing are described in this article. The findings show that MgFe2O4 films can be efficiently used for the detection of ethanol and acetone.
Energy Economics
Authors: Tyner Wallace E , Herath Nisal 
Published: October 2017

AbstractEnergy economics is a vast topic. Many applied and agricultural economists today work on fuel economy, fossil fuel energy issues, energy sector economic analysis, electricity sector economic and policy issues, techno‐economic analyses of energy alternatives as well as agricultural energy issues such as biofuels, and energy use in agriculture. Energy economists also employ a wide variety of modeling and analytical tools. We cover six broad topics: externalities, policy analysis, energy demand and supply analyses, electricity pricing, biofuels, and techno‐economic analysis. Applied and agricultural economists have made and will continue to make major contributions to the literature and policy analysis in these areas.
Detecting hidden batch factors through data-adaptive adjustment for biological effects
Authors: Yi Haidong , Raman Ayush T , Zhang Han , Allen Genevera I , Liu Zhandong 
Published: October 2017

AbstractMotivationBatch effects are one of the major source of technical variations that affect the measurements in high-throughput studies such as RNA sequencing. It has been well established that batch effects can be caused by different experimental platforms, laboratory conditions, different sources of samples and personnel differences. These differences can confound the outcomes of interest and lead to spurious results. A critical input for batch correction algorithms is the knowledge of batch factors, which in many cases are unknown or inaccurate. Hence, the primary motivation of our paper is to detect hidden batch factors that can be used in standard techniques to accurately capture the relationship between gene expression and other modeled variables of interest.ResultsWe introduce a new algorithm based on data-adaptive shrinkage and semi-Non-negative Matrix Factorization for the detection of unknown batch effects. We test our algorithm on three different datasets: (i) Sequencing Quality Control, (ii) Topotecan RNA-Seq and (iii) Single-cell RNA sequencing (scRNA-Seq) on Glioblastoma Multiforme. We have demonstrated a superior performance in identifying hidden batch effects as compared to existing algorithms for batch detection in all three datasets. In the Topotecan study, we were able to identify a new batch factor that has been missed by the original study, leading to under-representation of differentially expressed genes. For scRNA-Seq, we demonstrated the power of our method in detecting subtle batch effects.Availability and implementationDASC R package is available via Bioconductor or at https://github.com/zhanglabNKU/DASC.Supplementary informationSupplementary data are available at Bioinformatics online.
findGSE: estimating genome size variation within human and Arabidopsis using k-mer frequencies
Authors: Sun Hequan , Ding Jia , Piednoël Mathieu , Schneeberger Korbinian 
Published: October 2017

Abstract

Motivation
Analyzing k-mer frequencies in whole-genome sequencing data is becoming a common method for estimating genome size (GS). However, it remains uninvestigated how accurate the method is, especially if it can capture intra-species GS variation.

Results
We present findGSE, which fits skew normal distributions to k-mer frequencies to estimate GS. findGSE outperformed existing tools in an extensive simulation study. Estimating GSs of 89 Arabidopsis thaliana accessions, findGSE showed the highest capability in capturing GS variations. In an application with 71 female and 71 male human individuals, findGSE delivered an average of 3039 Mb as haploid human GS, while female genomes were on average 41 Mb larger than male genomes, in astonishing agreement with size difference of the X and Y chromosomes. Further analysis showed that human GS variations link to geographical patterns and significant differences between populations, which can be explained by variable abundances of LINE-1 retrotransposons.

Availability and implementation
R package of findGSE is freely available at https://github.com/schneebergerlab/findGSE and supported on linux and Mac systems.

Supplementary information
Supplementary data are available at Bioinformatics online.
Compression of genomic sequencing reads via hash-based reordering: algorithm and analysis
Authors: Chandak Shubham , Tatwawadi Kedar , Weissman Tsachy 
Published: October 2017

Abstract

Motivation
New Generation Sequencing (NGS) technologies for genome sequencing produce large amounts of short genomic reads per experiment, which are highly redundant and compressible. However, general-purpose compressors are unable to exploit this redundancy due to the special structure present in the data.

Results
We present a new algorithm for compressing reads both with and without preserving the read order. In both cases, it achieves 1.4×–2× compression gain over state-of-the-art read compression tools for datasets containing as many as 3 billion Illumina reads. Our tool is based on the idea of approximately reordering the reads according to their position in the genome using hashed substring indices. We also present a systematic analysis of the read compression problem and compute bounds on fundamental limits of read compression. This analysis sheds light on the dynamics of the proposed algorithm (and read compression algorithms in general) and helps understand its performance in practice. The algorithm compresses only the read sequence, works with unaligned FASTQ files, and does not require a reference.

Supplementary information
Supplementary material are available at Bioinformatics online. The proposed algorithm is available for download at https://github.com/shubhamchandak94/HARC.
Sovereignty, Territory, and Population in Jean Bodin’s
République
Authors: Miglietti Sara 
Published: October 2017

Abstract

This article offers a re-interpretation of Jean Bodin’s
Six livres de la République
(1576), a work that deeply transformed European political discourse at the time of the French Wars of Religion and that had important repercussions on the later ‘reason of state’ tradition. Highlighting the ties between Bodin’s definition of sovereignty in Book 1 and his discussion of demographic growth and territorial expansion in Books 4, 5, and 6, the article shows that Bodin’s critical contribution to early modern political thought, far from being limited to his reframing of the juristic concept of
souveraineté
or
maiestas
, extends to his novel understanding of the territory as a non-juridical ‘technologie politique’ (Michel Foucault). Through an examination of Bodin’s work and its later reception, the article argues that Bodin’s insights about territorial and demographic matters played a fundamental role in the early modern ‘territorialisation de la politique’ (Romain Descendre), in that they helped redefine the very terms in which the notion of territory would be understood and discussed in the following decades.
Escape rate for cod (Gadus morhua) from the codend during buffer towing
Authors: Brinkhof Jesse , Herrmann Bent , Larsen Roger B , Sistiaga Manu 
Published: October 2017

Abstract
The high abundances of Northeast Arctic cod (Gadus morhua) in the Barents Sea have led to the development of a new fishing tactic called buffer towing. On factory trawlers, the trawl is deployed immediately after taking the catch onboard, a tactic used to ensure a continuous supply of fish is being processed. If the desired amount of fish is caught before the catch from the previous haul has been fully processed, the trawl is lifted off the seabed and towed at a given depth at low speed. This is called buffer towing. Cod that escape from the codend when the trawl is shallower than the initial fishing depth are exposed to an increased likelihood of barotrauma-related injuries, increased disease susceptibility, and predation, which could be lethal, or affect growth and reproduction capability. Therefore, this study quantified the escape rate and size selectivity during buffer towing of cod. A new analytical method was applied that allows using the same trawl configuration as applied during commercial fishing and avoids potential bias in the assessment of buffer towing size selection. Our results demonstrated a significant size selection for cod during buffer towing where cod measuring up to at least 42 cm in length were proven to escape. In particular, at least 60% of cod measuring 20 cm were estimated to escape during buffer towing. For cod measuring 30 and 40 cm, at least 53 and 45% were estimated to escape during buffer towing, respectively.
Gene Expression Assays for Early-Stage Hormone Receptor–Positive Breast Cancer: Understanding the Differences
Authors: Nunes Ana Tablante , Collyar Deborah E , Harris Lyndsay N 
Published: October 2017

Abstract
Biomarkers are frequently used to guide decisions for treatment of early-stage estrogen (ER) and progesterone (PR) receptor–positive (ER/PR+) invasive breast cancers and have been incorporated into guidelines. The American Society of Clinical Oncology (ASCO) 2016 guideline and a 2017 update were recently published to help clinicians use the tests available. ASCO currently recommends five tests that show evidence of clinical utility based on the parameters defined in the guideline. These include the 21-gene assay (Oncotype DX), Prediction of Analysis of Microarray-50 (PAM50), 12-gene risk score (Endopredict), Breast Cancer Index (BCI), and, most recently, the 70-gene assay (Mammaprint). However, discordance is often seen when the results of these gene assays are compared in a particular patient, for a number of reasons: the assays were initially developed to answer different questions, and the molecular makeup of each signature reflects this; the patient populations that were studied also differed and may not reflect the patient being tested; furthermore, the study design and statistical analysis varied between each test, leading to different scoring scales that may not be comparable. In this review, the background on the development and validation of these assays is discussed, and studies comparing them are reviewed. To provide guidance on which test to choose, the studies that support the level of evidence for clinical utility are presented. However, the choice of a particular test will also be influenced by socioeconomic factors, clinical factors, and patient preferences. We hope that a better understanding of the scientific and clinical rationale for each test will allow patients and providers to make optimal decisions for treatment of early-stage ER/PR+ breast cancer.