bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Side Effects of the 2015–2016 High-Dose, Inactivated, Trivalent Influenza Vaccine and Standard Dose, Inactivated, Trivalent Influenza Vaccine in Adults ≥65 Years
Authors: Kaka Anjum S. , Filice Gregory A. , Myllenbeck Sharon , Nichol Kristin L. 
Published: January 2017

Abstract

Background
High-dose, inactivated, trivalent influenza vaccine (HD) is associated with higher rates of side effects than standard dose (SD) vaccine, which may represent a barrier to use.

Methods
We surveyed subjects ≥65 years who received either HD or SD vaccine at the Minneapolis Veteran Affairs Health Care System clinics on October 27, 28, or 29, 2015. Research assistants conducted a 17-item telephone survey of influenza vaccine recipients to inquire about self-reported health and symptoms experienced the week after vaccination.

Results
A total of 547 HD recipients and 541 SD recipients responded to the survey. The 2 groups were similar at baseline with respect to age, gender, and presence of high-risk medical conditions. At least ≥95% of individuals in both HD and SD groups reported that their overall health was the same or better than usual during the week after vaccination. Thirty-seven percent of HD recipients and 22% of SD recipients reported a local or systemic side effect (P &lt; .001), most of which were mild to moderate. Only 7 of 547 (1.3%) HD recipients and 3 of 541 (0.6%) SD recipients reported a severe side effect (P = .34). There was no significant difference in healthcare visits between the groups.

Conclusions
Side effects were more common among subjects ≥65 years who received HD influenza vaccine compared with SD vaccine. These side effects were well tolerated and were not associated with impairment of general health status. These findings should reassure patients and their providers of the safety and tolerability of the HD influenza vaccine.
Biomechanical Comparison of Cadaveric and Commercially Available Synthetic Osteoporotic Bone Analogues in a Locked Plate Fracture Model Under Torsional Loading
Authors: Becker Edward H. , Kim Hyunchul , Shorofsky Michael , Hsieh Adam H. , Watson Jeffrey D. , O'Toole Robert V. 
Published: January 2017

Objectives:
Biomechanical studies of osteoporotic bone have used synthetic models rather than cadaveric samples because of decreased variability, increased availability, and overall ease of the use of synthetic models. We compared the torsional mechanical properties of cadaveric osteoporotic bone with those of currently available synthetic osteoporotic bone analogues.

Methods:
We tested 12 osteoporotic cadaveric humeri and 6 specimens each of 6 types of synthetic analogues. A 5-mm fracture gap model and posterior plating technique with 4.5-mm narrow 10-hole locking compression plate were used. Torque was applied to a peak of ±10 N·m for 1000 cycles at 0.3 Hz. Data were continuously collected during cyclical and ramped loading with a servohydraulic materials testing system.

Results:
Cadaveric bone had a 17% failure rate before completing 1000 cycles. Three osteoporotic bone models had 100% failure (P < 0.05), 2 had 17% failure, and 1 had 0% failure before 1000 cycles. Significant differences in the stiffness of the 3 types of synthetic bone models that survived cyclic loading were noted compared with the cadaveric bone model (P < 0.05). Osteoporotic bone analogues had torsional mechanical properties different from those of osteoporotic cadaveric specimens.

Conclusions:
The differences between osteoporotic cadaveric humeri and synthetic osteoporotic bone analogues ranged from profound with complete catastrophic failure after a few cycles to subtler differences in stiffness and strain hardening. These findings suggest that different bone analogue models vary substantially in their torsional mechanical properties and might not be appropriate substitutes for cadaveric bone in biomechanical studies of osteoporotic bone.
Intravascular Papillary Endothelial Hyperplasia (Masson’s Tumor): Diagnosis the Plastic Surgeon Should Be Aware of
Authors: Boukovalas Stefanos , Dillard Rachel , Qiu Suimin , Cole Eric L 
Published: January 2017

Summary:
Intravascular papillary endothelial hyperplasia (IPEH) or Masson’s tumor is a rare benign entity commonly found on the head, neck, and upper extremities. It usually arises within a blood vessel but is considered to be a nonneoplastic reactive process often associated with vascular injury. Typically, IPEHs cause no symptoms and present as slowly growing soft-tissue masses. Given their prevalent location and indolent clinical presentation, the plastic surgeon should be familiar with this rare entity. We are presenting a case of IPEH of the forehead with unusual clinical and pathologic characteristics. Differential diagnosis, special considerations regarding preoperative work-up, and treatment options are discussed.
VITREOUS INCARCERATION IN SCLEROTOMIES AFTER VALVED 23-, 25-, OR 27-GAUGE AND NONVALVED 23- OR 25-GAUGE MACULAR SURGERY
Authors: Tosi Gian Marco , Malandrini Alex , Cevenini Gabriele , Neri Giovanni , Marigliani Davide , Cerruto Arianna , Virgili Gianni 
Published: January 2017

Purpose:
To study the patterns of vitreous incarceration at sclerotomy sites by ultrasound biomicroscopy in patients subjected to valved or nonvalved small-gauge pars plana vitrectomy.

Methods:
A prospective comparative study of 88 eyes affected by epiretinal membrane and macular hole. Patients were divided into four groups: valved or nonvalved 23-gauge (16 eyes each) and valved or nonvalved 25-gauge (20 eyes each); their vitreal disposition was compared by ultrasound biomicroscopy. Vitreal disposition was also assessed in 16 eyes of 16 patients subjected to valved 27-gauge pars plana vitrectomy.

Results:
Three vitreal patterns were identified: P0 (vitreous not visible or vitreous strand distant from the sclerotomy site), P1 (vitreous strand parallel to and in contact with the sclerotomy site), and P2 (vitreous strand entrapped in the sclerotomy site). The effect of valved trocar use on vitreous incarceration seemed to be somewhat beneficial, but no statistically significant effect could be shown (odds ratio: 0.85, 95% confidence interval: 0.42–1.74, P = 0.657). Similarly, no differences in vitreous incarceration were shown among vitrectomy gauges (23, 25, or 27) both in a model including valved trocars only (P = 0.858) and in a model with all available data (P = 0.935).

Conclusion:
In 23- and 25-gauge macular surgeries, postoperative vitreous incarceration does not seem to be reduced using valved cannulas and was similar to that observed in 27-gauge surgery.
Factors Associated With Graft Detachment After Primary Descemet Stripping Automated Endothelial Keratoplasty
Authors: Nahum Yoav , Leon Pia , Mimouni Michael , Busin Massimo 
Published: January 2017

Purpose:
To identify risk factors associated with postoperative graft detachment after Descemet stripping automated endothelial keratoplasty (DSAEK).

Methods:
In this retrospective institutional cohort study, the study group included all consecutive eyes that underwent primary DSAEK between January 2005 and October 2015 at Villa Serena-Villa Igea private hospitals (Forlì, Italy) and developed postoperative graft detachment (n = 45). The control group included all eyes that underwent primary DSAEK during the same period and did not develop graft detachment (n = 1167). The main outcome measure was whether or not postoperative graft detachment occurred.

Results:
Main indications for surgery included Fuchs endothelial dystrophy (525/1212 = 41%), pseudophakic bullous keratopathy (422/1212 = 35%), and a failed penetrating keratoplasty (PK) graft (190/1212 = 16%). Postoperative graft detachment occurred in 45 of 1212 (3.7%) eyes. Medically treated glaucoma, previous trabeculectomy, previous aqueous shunt procedure, and failed PK were all associated with an increased risk for graft detachment in univariate analysis. No particular lens status at the time of graft implantation was significantly associated with graft detachment, including the presence of an anterior chamber intraocular lens [odds ratio (OR), 1.5; 95% confidence interval (CI), 0.35–6.46, P = 0.58] or aphakia at the time of graft transplantation (OR, 1.37; 95% CI, 0.41–4.57, P = 0.74). Cataract removal during surgery was not associated with an increased risk for detachment (OR, 0.77; 95% CI, 0.39–1.5, P = 0.47). Previous trabeculectomy (OR, 4.21; 95% CI, 1.53–11.56, P = 0.005) and a previous failed PK graft (OR, 3.04; 95% CI, 1.6–5.78, P = 0.001) were the only independent risk factors for graft detachment in multivariate analyses.

Conclusions:
Previous PK and trabeculectomy are independent risk factors for postoperative graft detachment in primary DSAEK.
Asymmetric Deep Stromal Keratopathy in a Patient With Multiple Myeloma
Authors: Tainsh Laurel T. , Coady Patrick A. , Sinard John H. , Neparidze Natalia , Meskin Seth W. , Adelman Ron A. , Chow Jessica 
Published: January 2017

Purpose:
To report a case of asymmetric deep stromal keratopathy in a patient with multiple myeloma.

Methods:
Case report and literature review.

Results:
An 85-year-old woman was found to have progressive visually significant left-sided deep stromal opacity in the setting of monoclonal gammopathy. Hematologic workup resulted in a diagnosis of IgG kappa multiple myeloma. Histopathology was significant for semicrystalline deposits in the posterior stroma. The patient's visual acuity improved to 20/50 7 months after penetrating keratoplasty. A similar deep stromal lesion appeared in the right eye 2 years after initial presentation.

Conclusions:
We present an unusual case of paraproteinemic keratopathy with a uniquely asymmetric presentation that resulted in a diagnosis of multiple myeloma.
Lutein and Brilliant Blue-Based Dye for Donor Preparation and Transplantation in Descemet Membrane Endothelial Keratoplasty
Authors: Siebelmann Sebastian , Matthaei Mario , Hörster Robert , Cursiefen Claus , Bachmann Björn 
Published: January 2017

Purpose:
Trypan blue (TB) is used for visualization of the endothelium–Descemet membrane graft during Descemet membrane endothelial keratoplasty (DMEK). However, TB is assumed to have a dose-dependent toxic effect on the corneal endothelium. We retrospectively compared a lutein/zeaxanthin and Brilliant Blue (LZ/BB)-based dye for preparation and transplantation of the graft in DMEK to TB.

Methods:
In 20 patients, a dye composed of 1% LZ /0.025% BB was used, and in 22 patients, 0.06% TB was used for graft visualization in DMEK. We evaluated the rebubbling rate, best spectacle-corrected visual acuity (BSCVA), central corneal thickness (CCT), and endothelial cell density (ECD) before and 3 and 6 months after transplantation.

Results:
Staining of endothelium–Descemet membrane with LZ/BB was faint but sufficient. There was no significant difference between both groups, except in CCT after 3 months, which was lower in the LZ/BB group (P = 0.02). In the LZ/BB group, BSCVA improved from 0.48 ± 0.39 before DMEK to 0.19 ± 0.09 after 6 months (P < 0.05) (20% rebubbling rate). Donor ECD decreased from 2735 ± 259 cells/m2 preoperatively to 1876 ± 316 cells/mm2 (P < 0.0001) at 6 months (31.4%). CCT decreased from 642 ± 130 μm preoperatively to 519.8 ± 38 μm (P < 0.0001) at 6 months. In the TB group, BSCVA improved from 0.43 ± 0.27 to 0.17 ± 0.14 (P = 0.0003) at 6 months (30% rebubbling rate). ECD decreased from 2825 ± 263 to 1777 ± 302 cells/mm2 (P < 0.0001) after 6 months (36.3%), CCT from 638 ± 48 μm preoperatively to 531 ± 48 μm (P < 0.0001) at 6 months.

Conclusions:
LZ/BB-based dyes are suitable for DMEK with outcomes comparable to TB. However, available formulas result in faint staining, discouraging their routine use in donors with assumed difficult preparation.
Can Intoxication Status Be Used as a Prediction Tool for Manner of Death?
Authors: Molina D. Kimberley , Hargrove Veronica M. 
Published: January 2017

AbstractDetermining the manner of death in medicolegal death investigations can be difficult. The investigator relies on many facets of death investigation, including the circumstances of death and autopsy examination. A study was designed to analyze whether the intoxication status of the decedent could be used as another tool in death investigations. The intoxication status of violent (nonoverdose or poisoning) suicides and homicides was retrospectively reviewed and compared. A total of 625 deaths were identified, including 366 suicides and 259 homicides. Age, sex, cause of death, and intoxication status, including the specific drugs present, were analyzed. Gunshot wounds were the most common cause of death in both groups, with hanging being the second most common cause in suicides and sharp force injuries in homicides. Analysis found that although the overall intoxication status for suicides versus homicides did not differ significantly, certain drugs were more prevalent in one group over the other. Specifically, illicit drugs, that is, heroin, cocaine, and methamphetamine, were more likely to be present in homicides, whereas antidepressants or antipsychotics, benzodiazepines, and zolpidem were more common in suicides.
Persistence of antibiotic resistance plasmids in bacterial biofilms
Authors: Ridenhour Benjamin J. , Metzger Genevieve A. , France Michael , Gliniewicz Karol , Millstein Jack , Forney Larry J. , Top Eva M. 
Published: January 2017

ABSTRACTThe emergence and spread of antibiotic resistance is a crisis in health care today. Antibiotic resistance is often horizontally transferred to susceptible bacteria by means of multi-drug resistance plasmids that may or may not persist in the absence of antibiotics. Because bacterial pathogens often grow as biofilms, there is a need to better understand the evolution of plasmid persistence in these environments. Here we compared the evolution of plasmid persistence in the pathogenAcinetobacter baumanniiwhen grown under antibiotic selection in biofilms versus well-mixed liquid cultures. After four weeks, clones in which the plasmid was more stably maintained in the absence of antibiotic selection were present in both populations. On average plasmid persistence increased more in liquid batch cultures, but variation in the degree of persistence was greater among biofilm-derived clones. The results of this study show for the first time that the persistence of MDR plasmids improves in biofilms.
Dynamic patterning by theDrosophilapair-rule network reconciles long-germ and short-germ segmentation
Authors: Clark Erik 
Published: January 2017

ABSTRACTDrosophilasegmentation is a well-established paradigm for developmental pattern formation. However, the later stages of segment patterning, regulated by the “pair-rule” genes, are still not well understood at the systems level. Building on established genetic interactions, I construct a logical model of theDrosophilapair-rule system that takes into account the demonstrated stage-specific architecture of the pair-rule gene network. Simulation of this model can accurately recapitulate the observed spatiotemporal expression of the pair-rule genes, but only when the system is provided with dynamic “gap” inputs. This result suggests that dynamic shifts of pair-rule stripes are essential for segment patterning in the trunk, and provides a functional role for observed posterior-to-anterior gap domain shifts that occur during cellularisation. The model also suggests revised patterning mechanisms for the parasegment boundaries, and accounts for theeven-skippednull mutant phenotype. Strikingly, a slightly modified version of the model is able to pattern segments in either simultaneous or sequential modes, depending only on initial conditions. This suggest that fundamentally similar mechanisms may underlie segmentation in short-germ and long-germ arthropods.
Effects of explanations communicated in announcements of alleged labor abuses on valuation of a firm’s stock
Authors: Daly Joseph Patrick , Pouder Richard W. , McNeil Chris R. 
Published: January 2017

PurposeThe purpose of this paper is to gauge the impact of the following on the share price of a firm that has allegedly committed labor abuses: the allegation itself, explanations (justifications and excuses) offered by the company spokesperson, and denials of responsibility for the alleged abuse.Design/methodology/approachThe study uses archival data and an event study methodology.FindingsLabor abuse allegations have a negative impact on the firm’s share price. Allegations that are accompanied by an explanation (a justification or excuse) have a less negative impact than those that are not accompanied by an explanation. Denials of responsibility have a negative influence on the share price.Practical implicationsIf managers want to avoid a negative hit on the share price from an allegation of wrongdoing, they should provide an explanation (a justification or excuse) and avoid the use of denials.Originality/valuePrior research has shown a negative impact from several types of labor abuse. This study extends prior research by showing a negative impact for all forms of labor abuse as a general category; it also extends findings from lab research on the impact of explanations on fairness judgments to a new context and a new dependent variable (the financial performance of the firm), which is on an organizational scale. It adds to the extreme paucity of empirical findings relative to the impact of denials and also adds to a small but growing literature on fairness judgments by third parties and their consequences.
Exploring correlations in components of green supply chain practices and green supply chain performance
Authors: Sharma Sanjay , Gandhi Mohd. Asif 
Published: January 2017

PurposeThe purpose of this paper is to explore the peer-reviewed literature, as well as literature written by practitioners having authority on green supply chains and allied areas with a view to identify future research directions with the help of an extensive literature review.Design/methodology/approachIn line with this objective, the constructs “Green Supply Chain Practices” and “Green Supply Chain Performance” were the two terms that were identified for a co-relational study.FindingsAs indicated by the literature review, there is a need to do a more detailed study that can pinpoint particular components of green supply chain practices that have a strong association with particular components of green supply chain performance. This paper attempts to achieve the aim by using a different connotation of these two constructs.Originality/valueSuch a study with the connotation and components of green supply chain (GSC) practices and GSC performance as identified and used in this paper might not have been conducted before in the way it is proposed to be used in this paper, thus making this an appropriate contribution. Accordingly, a framework for the research has been depicted, and research questions have been framed.
Sustainable green supply chain management: trends and current practices
Authors: Singh Amol , Trivedi Ashish 
Published: January 2017

PurposeThe purpose of this paper is to give an up-to-date and structured insight into the literature published during the past decade on sustainable green supply chain management. It also suggests trends for future research based on the research issues identified through systematic and comprehensive analysis of previous studies in the area of green and sustainable supply chain management.Design/methodology/approachA state-of-the-art literature review is carried out by systematically collecting the existing literature over a period of 10 years (2005-2014) and categorizing it on the basis of attributes such as stages in supply chain, methodology and the industries/sectors under consideration. The classification of literature is also done according to the geographic region and year of publication.FindingsThere has been an increased interest among researchers and practitioners in the area of sustainable green supply chain management in the past decade. A need for achieving sustainability through adoption of greener practices has been universally felt, owing to an increasing environmental and ecological complexity. The review reveals that there exists a need to address behavioural issues like human resource management and supply chain partner relationship management. Moreover, reverse logistics, closed-loop supply chain management and waste management are areas that need special focus to achieve environmental sustainability.Research limitations/implicationsThe current review focuses on research trends in the past 10 years only. Moreover, papers from only good quality, peer-reviewed journals are considered in the study.Originality/valueMost of the previous reviews have either focused on specific issues related to sustainable supply chains only or green supply chains. The present study collectively takes into consideration papers both from green supply chain management as well as from sustainable supply chain literature that have a prime focus on environmental sustainability.
An evaluation of EU member states according to human development and global competitiveness dimensions using the multi-period grey relational analysis (MP-GRA) technique
Authors: Eren Miraç , Kaynak Selahattin 
Published: January 2017

Purpose
The purpose of this paper is to investigate the multi-period, multi-attribute decision-making problems that arise when the information required to make decisions is provided at different periods.

Design/methodology/approach
For the multi-period grey relational analysis (MP-GRA) procedure, the time dimension is added to the grey relational analysis algorithm, which is a multi-attribute decision analysis that has been developed. As a case study to test the functionality and applicability of the model, 28 European Union member states were ranked by the MP-GRA method developed according to their human development and global competitiveness variables for the years 2006-2015.

Findings
The general ranking of EU member states has been provided in intervals of certain time periods called decision units.

Originality/value
Another dimension based on time periods has been added to a ranking technique. This case also shows that the opinions of decision-makers may be added separately to enhance evaluations.
Explanation of terms of grey incidence analysis models
Authors: Liu Sifeng , Zhang Hongyang , Yang Yingjie 
Published: January 2017

Purpose
The purpose of this paper is to present the terms of grey incidence analysis models.

Design/methodology/approach
The definitions of basic terms about various grey incidence analysis models are presented one by one.

Findings
The reader could know the basic explanation about the important terms about various grey incidence analysis models from this paper.

Practical implications
Many of the authors’ colleagues thought that unified definitions of key terms would be beneficial for both the readers and the authors.

Originality/value
It is a fundamental work to standardize all the definitions of terms for a new discipline. It is also propitious to spread and universal of grey system theory.