bluuebunny/crossref_metadata_2025_split huggingface dataset:
Respon Pemberian Pupuk Organik Limbah Cair Tahu dan Paparan Gelombang Suara Sonic Bloom Terhadap Pertumbuhan Tanaman Kangkung Darat (Ipomoea reptans Poir.)
Authors: Lestari Rizka Putri , Laili Saimul , Tito Sama' Iradat 
Published: September 2024

Kangkung (Ipomoea reptans Poir.) is a seasonal and short-lived vegetable that can be cultivated organically. One of them is by utilizing tofu liquid waste, because tofu liquid waste itself contains organic matter which has the potential to be used as organic fertilizer. Current attempts to increase vegetable production are contuining, one of the environmentally friendly technologies that utilizes sound waves is Sonic bloom. Sonic bloom can help open leaf stomata to be wider, so it will spur plant vegetative growth. Therefore, this study was conducted to determine the response to tofu liquid waste organic fertilizer and exposure to sonic bloom sound waves on kangkung growth. This study used factorial Group Randomized Design (RAK) which consist of five treatments and four repeats with the giving of different concentrations of tofu liquid waste and exposure to sonic bloom sound waves in plants. The data were analyzed by Analysis of variance (Anova) calculations and the smallest real difference test with a level of 5%. The results showed that the giving of tofu liquid waste organic fertilizer and exposure to sonic bloom sound waves were significantly different from the growth of kangkung such as plant height, number of leaves, leaf area and, wet weight of plants, stomata width and amount of leaf stomata, and do not differ markedly in dry weight.Keywords: kangkung, tofu liquid waste, vegetative growth, sonic bloomABSTRAKKangkung darat (Ipomoea reptans Poir.) merupakan sayuran semusim dan berumur pendek yang dapat dibudidayakan secara organik. Salah satunya yaitu dengan memanfaatkan limbah cair tahu, karena limbah cair tahu sendiri mengandung bahan organik yang berpotensi sebagai pupuk organik. Saat ini upaya untuk meningkatkan hasil produksi sayur terus dilakukan, salah satu teknologi ramah lingkungan yang memanfaatkan gelombang suara yaitu sonic bloom. Sonic bloom dapat membantu terbukanya stomata daun menjadi lebih lebar, sehingga akan memacu pertumbuhan vegetatif tanaman. Oleh karena itu, penelitian ini bertujuan untuk mengetahui respon pemberian pupuk organik limbah cair tahu serta paparan gelombang suara sonic bloom pada pertumbuhan kangkung. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) yang terdiri dari lima perlakuan dan empat ulangan dengan pemberian konsentrasi pupuk organik limbah cair tahu yang berbeda serta paparan gelombang suara sonic bloom pada tanaman. Data dianalisis dengan perhitungan Analisis sidik ragam (Anova) dan Uji Beda Nyata Terkecil dengan taraf 5%. Hasil penelitian menunjukkan pemberian limbah cair tahu dan paparan gelombang suara sonic bloom berbeda nyata terhadap pertumbuhan kangkung darat seperti tinggi tanaman, jumlah daun, luas daun dan, berat basah tanaman, lebar stomata dan jumlah stomata, serta tidak berbeda nyata pada berat kering tanaman. Kata kunci: kangkung darat, limbah cair tahu, pertumbuhan vegetatif, sonic bloom
Analisis Kandungan Total Fenol pada Kulit Delima Putih (Punica granatum L.) Menggunakan Metode Folin
Authors: Rafsanjani Ramizard , Januarista Terra , Faisal Faisal , Ramadhan Majida 
Published: September 2024

White pomegranate is often used as medicine because it has higher antioxidants than red and purple pomegranates.Since white pomegranate peel contains phenolic compounds that function as natural antioxidants, white pomegranate peel extract has higher phenol content than its extract.The results of analyzing the total phenol content of white pomegranate peel (Punica granatum L.) is the purpose of this study.In this study, Follin Ciocalteu method and UV-Vis spectrophotometry were used.The results showed that white pomegranate peel (Punica granatum L.) had a total phenol content of 282 grams GAE/ml. Keywords: White Pomegranate Peel, Total phenolics, AntioxidantABSTRAKDalam kelas Magnoliophyta, delima (Punica granatum L.) adalah tanaman hortikultura. Delima putih sering digunakan sebagai obat karena memiliki antioksidan yang lebih tinggi daripada delima merah dan ungu. Karena kulit buah delima putih mengandung senyawa fenolik yang berfungsi sebagai antioksidan alami, ekstrak kulit delima putih memiliki kadar fenol yang lebih tinggi daripada ekstraknya. Hasil analisis kandungan fenol total kulit buah delima putih (Punica granatum L.) adalah tujuan penelitian ini. Dalam penelitian ini, metode Follin Ciocalteu dan spektrofotometri UV-Vis digunakan. Hasil penelitian menunjukkan bahwa kulit delima putih (Punica granatum L.) memiliki kadar fenol total 282 gram GAE/ml.Kata Kunci : Kulit Delima Putih, Total fenol, Antioksidan
APLIKASI VARIASI PUPUK ORGANIK PADAT LIMBAH FRASS ULAT HONGKONG DAN BIOCHAR TONGKOL JAGUNG TERHADAP PRODUKTIVITAS MENTIMUN CU 699
Authors: Fikriyah Khafivatul , Laili Saimul , Tito Sama' Iradat 
Published: September 2024

The cucumber plant (Cucumis sativus L.) is a horticultural commodity that has various benefits in terms of health, beauty and consumption needs, however, cucumber production has decreased so that cultivation systems need to be improved. Processing mealworm frass as fertilizer and using corn cobs as biochar are sustainable environmental management efforts that can support the agricultural sector in the future. The aim of this research is to analyze the effect of using solid organic fertilizer, mealworm frass and corncob biochar on the productivity of CU 699 cucumbers, as well as determining the best treatment for plant productivity. This research used the Randomized Block Design (RAK) method. Data analysis used One Way ANOVA and Tukey HSD further test. The observations made included biotic and abaiotic factors. Productivity parameters include number of flowers, number of fruit, fruit size, and fresh weight of fruit. Environmental parameters include air temperature, soil pH, soil moisture, and light intensity. The results showed that giving mealworm frass and corncob biochar did not have an effect on productivity. The best treatment for productivity is P2B0. ABSTRAK Tanaman timun (Cucumis sativus L.) merupakan salah satu komoditas holtikultura yang memiliki berbagai manfaat baik dari segi kesehatan, kecantikan, hingga keperluan konsumsi, namun produksi timun mengalami penurunan sehingga perlu perbaikan pada sistem budidaya. Pengolahan frass ulat hongkong sebagai pupuk dan pemanfaatan tongkol jagung sebagai biochar merupakan upaya pengelolaan lingkungan berkelanjutan yang mampu mendukung bidang pertanian di masa depan. Tujuan penelitian ini adalah untuk menganalisis pengaruh penggunaan pupuk organik padat frass ulat hongkong dan biochar tongkol jagung terhadap produktivitas timun CU 699, serta menentukan perlakuan terbaik untuk produktivitas tanaman. Penelitian ini menggunakan metode Rancangan Acak Kelopok (RAK). Analisis data menggunakan One Way ANOVA dan uji lanjut Tukey HSD. Pengamatan yang dilakukan meliputi faktor biotik dan abaiotik. Parameter penelitian meliputi jumlah bunga, jumlah buah, ukuran buah, dan berat basah buah. Parameter lingkungan meliputi suhu udara, pH tanah, kelembaban tanah, dan intensitas cahaya. Hasil penelitian menunjukkan bahwa pemberian frass ulat hongkong dan biochar tongkol jagung tidak memberikan efek pada produktivitas. Perlakuan terbaik untuk produktivitas adalah pada P2B0.
Experience of using lenvatinib in the treatment of hepatocellular cancer at the Republican Oncology Center of the Republic of North Ossetia-Alania in 2018–2022. Balance of efficiency and accessibility in regional practice
Authors: Bolieva M. B. , Yepkhiev A. A. , Voronkova L. M. , Zangionov G. E. 
Published: September 2024

The overall incidence of liver cancer in the Republic of North Ossetia-Alania has remained stable over the past five years. Moreover, the initial diagnostic of HCC occurs at widespread stage, which limits the possibilities of cured therapy. The Republican Oncology Clinic has accumulated experience in using the drug lenvatinib for advanced and metastatic hepatocellular cancer. In the realities of a small regional dispensary, and has to find a balance between efficiency and availability of therapeutic options to provide effective therapy for all patients. The authors conducted a single-center retrospective analysis of the effectiveness and safety of lenvatinib in real clinical practice in patients with hepatocellular cancer at the Republican Oncology Center of the Republic of North Ossetia Alania. The analysis included 18 patients with HCC who received lenvatinib monotherapy. 11(61%) patients had concomitant viral hepatitis B or C, 15 (83%) had distant metastases to the lymph nodes, lungs, adrenal glands or other organs. A feature of this patient population is the long period of time from the prescription of drug therapy for HCC to its actual start – on average 46 days, with a range from 5 to 100 days. We believe that a delay in initiating therapy may affect the results obtained. Median PFS in 1st line of lenvatinib therapy was 10.1 months (2.3 months to 13.1 months). Median PFS2 (defined as the time from 1st line treatment on lenvatinib to progression on first subsequent therapy) was 19.1 months. 6 (33%) patients received lenvatinib in the second line after progression on another drug therapy. The median second-line PFS in this case was 5.9 months (3.8 months‑7.7 months). Lenvatinib had a manageable and predictable tolerability profile. No new safety signals were identified.Conclusion: The use of lenvatinib as monotherapy in adult patients with advanced or unresectable hepatocellular carcinoma has proven to be an effective strategy that balances clinical benefit and availability of the drug.
Peranan Analisa Selisih Biaya Overhead Pabrik dalam Pengendalian Biaya Produksi pada PT. Kaleng Raya Sidoarjo Tahun 2020
Authors: Rhokmawati Suci , Ardiana Meta 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui penerapan selisih biaya overhead pabrik dalam pengendalian biaya produksi pada PT. Kaleng Raya Sidoarjo tahun 2020.Metode penelitian ini memakai metode kualitatif sedangkan pendekatan penelitiannya yakni deskriptif. Hasil penelitian ini memberitahukan kalau analisis selisih biaya overhead pabrik PT. Kaleng Raya Sidoarjo tahun 2020 yang memakai model 4 selisih. Terjadi selisih menguntungkan pada selisih pengeluaran, serta terjadi selisih menguntungkan pula pada selisih kapasitas dan selisih efisiensi mengalami selisih yang merugikan, selisih efisiensi ini dipecah menjadi 2 yiatu selisih efisiensi tetap dan selisih efisiensi variabel, kedua selisih tersebut juga mengalami selisih yang merugikan. Selisih yang menguntungkan dicapai perusahaan lebih besar daripada selisih merugikan, sehingga perusahaan bisa dikatakan lumayan efisien dalam pengendalian biaya produksi. Ketika terjadi selisih yang menguntungkan hingga perusahaan mesti atau wajib mempertahankannya dan juga butuh ditingkatkannya lagi di periode berikutnya. Bila terjadi selisih yang merugikan sehingga pihak perusahaan harus mencari pemicu atau penyebab terbentuknya selisih tersebut dan mendapatkan penyelesaian yang terbaik untuk segera mengatasinya
Pengaruh Rasio Keuangan Terhadap Pertumbuhan Laba (Studi pada Perusahaan Pertambangan Migas Listing BEI Tahun 2016-2020)
Authors: Solicha Dara Puspita , Pertiwi Dwi Ari 
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh rasio keuangan terhadap pertumbuhan laba studi pada perusahaan pertambangan migas listing BEI tahun 2016-2020. Teknik sampel yang digunakan pada penelitian ini yaitu purposive sampling dan mendapatkan jumlah sampel sebanyak 30 laporan keuangan perusahaan pertambangan migas listing BEI tahun 2016-2020. Analisis data yang digunakan pada penelitian ini yaitu dengan menggunakan uji regresi linier berganda, serta uji hipotesis yang mencakup uji parsial, simultan dan koefisien regresi. Hasil dari penelitian ini menunjukkan bahwa Quick Ratio dan Debt to Asset Ratio tidak berpengaruh terhadap pertumbuhan laba pada perusahaan pertambangan migas listing BEI tahun 2016-2020, Return on Asset dan Inventory Turnover mempunyai pengaruh terhadap pertumbuhan laba pada perusahaan pertambangan migas listing BEI tahun 2016-2020.
Genetic landscape of ESBL producing international clone ST410 of Escherichia coli from pediatric infections in Shenzhen, China
Authors: Patil Sandip , Pai Liu , Chen Hongyu , Chen Yunsheng , Xinye Li , Dong Shaowei , Kaushik Sanket , Lopes Bruno Silvester , Chen Xiaowen , Liu Sixi , Wen Feiqiu 
Published: September 2024

BackgroundThe emergence of ESBLs producing cephalosporin-resistant Escherichia coli isolates poses a threat to public health. This study aims to decipher the genetic landscape and gain insights into ESBL-producing E. coli strains belonging to the high-risk clone ST410 from pediatric patients.Methods29 E. coli ST410 isolates were collected from young children and subjected to antimicrobial susceptibility testing, Whole-genome sequencing (WGS), serotype analysis, MLST, ESBL genes, virulence genes, and plasmid profiling.ResultsAntimicrobial susceptibility testing demonstrated a high level of resistance to cephalosporins followed by aminoglycoside, sulfonamide, carbapenem and penicillin group of antibiotics. However, n=20/29 shows MDR phenotype. Phylogenetic group B2 (n=15) dominated, followed by group D (n=7), group A (n=4), and group B1 (n=3). Serotyping analysis identified O1:H7 (n=8), O2:H1 (n=6), O8:H4 (n=5), O16:H5 (n=4), and O25:H4 (n=3). Other serotypes identified included O6:H1, O15:H5, and O18:H7 (n=1 each). The most commonly detected ESBL genes were blaCTX-M, (n=26), followed by blaTEM (n=23), and blaSHV (n=18). Additionally, blaOXA-1 (n=10), blaOXA-48 (n=5), blaKPC-2 (n=3), blaKPC-3 (n=2), blaNDM-1 (n=4), blaNDM-5 (n=1), blaGES-1 (n=2), blaGES-5 (n=1), and blaCYM-1 (n=3). Notable virulence genes identified within the ST410 isolates included fimH (n=29), papC (n=24), hlyA (n=22), and cnf1 (n=18), among others. Diverse plasmids were observed including IncFIS, IncX4, IncFIA, IncCol, IncI2 and IncFIC with transmission frequency ranges from 1.3X10-2 to 2.7X10-3.ConclusionThe ST410 clone exhibited a complex resistance profile, diverse serotypes, the presence of specific resistance genes (ESBL genes), virulence gene repertoire, and diverse plasmids. The blaCTX-M was the most prevalent ESBL gene detected.
Analysis of macrophage polarization and regulation characteristics in ovarian tissues of polycystic ovary syndrome
Authors: Yuan Yue , Mao Yan , Yang Liu , Wang Yilin , Zhang Xuehong 
Published: September 2024

BackgroundPolycystic ovary syndrome (PCOS) can lead to infertility and increase the risk of endometrial cancer. Analyzing the macrophage polarization characteristics in ovarian tissues of PCOS is crucial for clinical treatment.MethodsWe obtained 13 PCOS and nine control ovarian samples from the CEO database and analyzed differentially expressed genes (DEGs). Macrophage polarization-related genes (MPRGs) were sourced from the GeneCards and MSigDB databases. Intersection of DEGs with MPRGs identified DEGs associated with macrophage polarization (MPRDEGs). Gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Protein–protein interaction (PPI) Network analysis were conducted on MPRDEGs. Moreover, the top 10 genes from three algorithms were identified as the hub genes of MPRGs. In addition, miRNAs, transcription factors (TFs), and drugs were retrieved from relevant databases for regulatory network analysis of mRNA-miRNA, mRNA-TF, and mRNA-Drug interactions. Immune cell composition analysis between the PCOS and control groups was performed using the CIBERSORT algorithm to calculate correlations across 22 immune cell types.ResultsA total of 13 PCOS samples and nine control ovarian samples were obtained in this study. We identified 714 DEGs between the two groups, with 394 up-regulated and 320 down-regulated. Additionally, we identified 774 MPRGs, from which we derived 30 MPRDEGs by intersecting with DEGs, among which 21 exhibited interaction relationships. GO and KEGG analyses revealed the enrichment of MPRDEGs in five biological processes, five cell components, five molecular functions, and three biological pathways. Immune infiltration analysis indicated a strong positive correlation between activated nature killer (NK) cells and memory B cells, while neutrophils and monocytes showed the strongest negative correlation. Further investigation of MPRDEGs identified nine hub genes associated with 41 TFs, 82 miRNAs, and 44 drugs or molecular compounds. Additionally, qRT-PCR results demonstrated overexpression of the CD163, TREM1, and TREM2 genes in ovarian tissues from the PCOS group.ConclusionThis study elucidated the polarization status and regulatory characteristics of macrophages in ovarian tissues of the PCOS subjects, confirming significant overexpression of CD163, TREM1, and TREM2. These findings contribute to a deeper understanding of the pathogenesis of PCOS.
Intraoperative end-tidal carbon dioxide levels are not associated with recurrence-free survival after elective pancreatic cancer surgery: a retrospective cohort study
Authors: Dehne Sarah , Kirschner Lina , Klotz Rosa , Kilian Samuel , Michalski Christoph W. , Hackert Thilo , Büchler Markus W. , Weigand Markus A. , Larmann Jan 
Published: September 2024

BackgroundIntraoperative end-tidal carbon dioxide concentrations (EtCO2) values are associated with recurrence-free survival after colorectal cancer surgery. However, it is unknown if similar effects can be observed after other surgical procedures. There is now evidence available for target EtCO2 and its relation to surgical outcomes following pancreatic cancer surgery.MethodsIn this single-center, retrospective cohort study, we analyzed 652 patients undergoing elective resection of pancreatic cancer at Heidelberg University Hospital between 2009 and 2016. The entire patient cohort was sorted in ascending order based on mean intraoperative EtCO2 values and then divided into two groups: the high-EtCO2 group and the low-EtCO2 group. The pre-specified primary endpoint was the assessment of recurrence-free survival up to the last known follow-up. Cardiovascular events, surgical site infections, sepsis, and reoperations during the hospital stay, as well as overall survival were pre-specified secondary outcomes.ResultsMean EtCO2 was 33.8 mmHg ±1.1 in the low-EtCO2 group vs. 36.8 mmHg ±1.9 in the high-EtCO2 group. Median follow-up was 2.6 (Q1:1.4; Q3:4.4) years. Recurrence-free survival did not differ among the high and low-EtCO2 groups [HR = 1.043 (95% CI: 0.875–1.243), log rank test: p = 0.909]. Factors affecting the primary endpoint were studied via Cox analysis, which indicated no correlation between mean EtCO2 levels and recurrence-free survival [Coefficient −0.004, HR = 0.996 (95% CI:0.95–1.04); p = 0.871]. We did not identify any differences in the secondary endpoints, either.ConclusionsDuring elective pancreatic cancer surgery, anesthesiologists should set EtCO2 targets for reasons other than oncological outcome until conclusive evidence from prospective, multicenter randomized controlled trials is available.
A prediction model to differentiate transient ischemia from irreversible transmural necrosis in closed-loop small bowel obstruction
Authors: Pan Shaorong , Yang Jiejin , Liu Zining , Nai Rile , Chen Zeyang 
Published: September 2024

IntroductionThe study aims to develop a prediction model to differentiate transient ischemia from irreversible transmural necrosis in closed-loop small bowel obstruction (CL-SBO).MethodsA total of 180 participants with CL-SBO between January 2010 and December 2019, of which 122 had complete radiologic data, were included to investigate the significant clinical and imaging characteristics for differentiating patients with necrosis from transient ischemia. A logistic regression model was developed and validated.ResultsIn a multivariate analysis, the American Society of Anesthesiologists physical status classification system &gt;2 is the independent predictor for transmural necrosis. Another multivariate analysis, including clinical and imaging factors, revealed that the imaging sign of mesenteric vessel interruption was an independent risk factor for necrosis. The diagnostic model developed using these two factors has excellent performance among the validation sets, with an area under the curve of 0.89.ConclusionThe diagnostic model and innovative imaging signs have substantial potential in solving this complex clinical problem.
Antimicrobial resistance and genomic analysis of Vibrio parahaemolyticus isolates from foodborne outbreaks, Huzhou, China, 2019–2023
Authors: Yan Wei , Ji Lei , Dong Fenfen , Chen Liping , Yuan Rui , Zhang Peng 
Published: September 2024

ObjectiveThe purpose of this study was to investigate the epidemiological and genomic characteristics of Vibrio parahaemolyticus (V. parahaemolyticus) isolates from outbreaks in Huzhou, China.MethodsThis study aims to analyze the epidemiological data on V. parahaemolyticus outbreaks reported in Huzhou from 2019 to 2023. A total of 70 V. parahaemolyticus outbreak isolates were collected. The antibiotic resistance, serotypes, molecular typing, and genomic characteristics of these isolates were analyzed.ResultsMost outbreaks of V. parahaemolyticus infection occurred in the summer, and the majority of outbreaks occurred in restaurants and rural banquets. High resistance rates were observed for ampicillin (AMP, 24.29%), followed by tetracycline (TET, 15.71%) and trimethoprim-sulfamethoxazole (SXT, 15.71%). The newly emerged serotype O10:K4 became dominant from 2021 to 2023, with most isolates belonging to ST3. The resistance gene blaCARB was frequently detected among these isolates. The pulsed-field gel electrophoresis (PFGE) and whole-genome single-nucleotide polymorphisms (wgSNPs) effectively differentiated the nine outbreaks.ConclusionThe newly emerged serotype O10:K4 became dominant from 2021 to 2023, with most isolates being ST3. PFGE and WGS technologies provided reliable methods for typing and identifying V. parahaemolyticus for outbreaks.
Association between blood pressure and dementia in older adults: a cross-sectional study from China
Authors: Yi Tingting , Su Zhou , Wang Jiyang , Gan Jinghuan , Wu Hao , Shi Zhihong , Sun Zhen , Liu Shuai , Ji Yong 
Published: September 2024

Background and aimsThe association between blood pressure (BP) and dementia in older adults remains unclear, prompting this study to investigate the relationship between various BP indicators and dementia in this population.MethodsA cross-sectional survey was conducted in 2019, including 3,599 participants aged 65 years or older. The basic demographic characteristics of participants were collected. BP measurements and neuropsychological assessments were performed. From the systolic BP (SBP) and diastolic BP (DBP) values, mean arterial pressure (MAP), pulse pressure (PP) and blood pressure index (BPI) were calculated. Generalized additive models and logistic regression models were used to analyze the association between BP indicators and dementia.ResultsGeneralized additive models identified a U-shaped relationship between DBP and dementia, which was more significant in males and people 70 years of age and older. The optimal DBP associated with the lowest dementia risk was 85 mmHg. Logistic regression models revealed that compared to the DBP subgroup (80–89 mmHg), participants in the DBP &lt; 80 mmHg subgroup and the DBP ≥100 mmHg subgroup had OR for dementia of 1.611 (95% CI: 1. 252–2.073, P &lt; 0.001) and 1.423 (95% CI: 0.999–2.028, p = 0.050), respectively. A significant association was observed between BPI and dementia (OR:1.746 95% CI: 1.142–2.668, p = 0.010).ConclusionIn older adults, we found a U-shaped relationship between DBP and dementia, and a linear relationship between BPI and dementia. These results underscore the importance of considering DBP and BPI in BP management strategies for older adults to potentially prevent or delay dementia onset.