bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feasibility of real‐time near‐infrared indocyanine green fluorescence endoscopy for the evaluation of mucosal head and neck lesions
Authors: Schmidt Florian , Dittberner Andreas , Koscielny Sven , Petersen Iver , Guntinas–Lichius Orlando 
Published: September 2016

AbstractBackgroundThe purpose of this study was to explore the feasibility and potential drawbacks of near‐infrared (NIR) endoscopy with indocyanine green (ICG) to examine mucosal head and neck lesions.MethodsNIR ICG endoscopy was applied to image head and neck cancer epithelium in vivo. The evaluation of the ICG videos was performed off‐line independently by 2 evaluators and blinded with respect to final histopathological results from biopsies taken as the gold standard.ResultsForty percent of the lesions from 55 patients were histologically malignant. ICG positivity showed a sensitivity, specificity, and accuracy to be related to a malignant tumor of 90.5%, 90.9%, and 89.1%, respectively. The kappa index for the interobserver assessment showed a 94.4% agreement for the assessment of the ICG positivity. Side effects of the NIR ICG endoscopy did not arise.ConclusionNIR ICG endoscopy in patients with mucosal head and neck lesions was feasible and safe. It might help intraoperatively to differentiate benign from malignant lesions. © 2016 Wiley Periodicals, Inc. Head Neck 39: 234–240, 2017
Precocious Phenotypic Transcription‐Factor Expression During Early Development
Authors: VanOudenhove Jennifer J. , Medina Ricardo , Ghule Prachi N. , Lian Jane B. , Stein Janet L. , Zaidi Sayyed K. , Stein Gary S. 
Published: September 2016

ABSTRACTA novel role for phenotypic transcription factors in very early differentiation was recently observed and merits further study to elucidate what role this precocious expression may have in development. The RUNX1 transcription factor exhibits selective and transient upregulation during early mesenchymal differentiation. In contrast to phenotype‐associated transcriptional control of gene expression to establish and sustain hematopoietic/myeloid lineage identity, precocious expression of RUNX1 is functionally linked to control of an epithelial to mesenchymal transition that is obligatory for development. This early RUNX1 expression spike provides a paradigm for precocious expression of a phenotypic transcription factor that invites detailed mechanistic study to fully understand its biological importance. J. Cell. Biochem. 118: 953–958, 2017. © 2016 Wiley Periodicals, Inc.
A kidney injury molecule‐1 (Kim‐1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells
Authors: Kokura Kenji , Kuromi Yasushi , Endo Takeshi , Anzai Naohiko , Kazuki Yasuhiro , Oshimura Mitsuo , Ohbayashi Tetsuya 
Published: September 2016

AbstractBackgroundKidney injury molecule‐1 (Kim‐1) has been validated as a urinary biomarker for acute and chronic renal damage. The expression of Kim‐1 mRNA is also activated by acute kidney injury induced by cisplatin in rodents and humans. To date, the measurement of Kim‐1 expression has not fully allowed the detection of in vitro cisplatin nephrotoxicity in immortalized culture cells, such as human kidney‐2 cells and immortalized proximal tubular epithelial cells.MethodsWe measured the augmentation of Kim‐1 mRNA expression after the addition of cisplatin using immortalized S3 cells established from the kidneys of transgenic mice harboring temperature‐sensitive large T antigen from Simian virus 40.ResultsA mouse Kim‐1 gene luciferase reporter in conjunction with an Hprt gene reporter detected cisplatin‐induced nephrotoxicity in S3 cells. These two reporter genes were contained in a mouse artificial chromosome, and two luciferases that emitted different wavelengths were used to monitor the respective gene expression. However, the Kim‐1 reporter gene failed to respond to cisplatin in A9 fibroblast cells that contained the same reporter mouse artificial chromosome, suggesting cell type‐specificity for activation of the reporter.ConclusionsWe report the feasibility of measuring in vitro cisplatin nephrotoxicity using a Kim‐1 reporter gene in S3 cells.
Long‐term outcomes after revision of Kasai portoenterostomy for biliary atresia
Authors: Shirota Chiyoe , Uchida Hiroo , Ono Yasuyuki , Murase Naruhiko , Tainaka Takahisa , Yokota Kazuki , Oshima Kazuo , Shirotsuki Ryo , Hinoki Akinari , Ando Hisami 
Published: September 2016

AbstractBackgroundThe indications for and efficacy of revision of portoenterostomy (PE) for biliary atresia (BA) needs to be reassessed in an era of liver transplantation. We therefore reviewed the long‐term outcomes following revision of PE.MethodsThis was a retrospective study of the medical records of patients with BA who underwent PE and revision of PE. We investigated the role of revision on outcomes of jaundice‐free native liver survival (approval number: 2015–0094).ResultsPortoenterostomy was performed in 76 patients, among whom 22 underwent revision. Revision for recurrent jaundice was performed for four of 51 patients, who were transiently jaundice free after initial PE, but only one achieved native liver survival. Revision for repeated cholangitis in two patients achieved native liver survival over 10 years. Revision was performed in 16 of the 25 patients in whom initial PE failed; of these, four survived with their native liver (ages 3, 12, 12, and 14 years). The PE revision did not significantly affect liver transplantation duration and survival outcome.ConclusionsRevision of PE was suitable for repeated cholangitis. Revision for recurrent jaundice, regardless of whether the initial PE was successful, could have a limited but positive effect in preventing long‐term progressive liver failure.
Educating local radial basis functions using the highest gradient of interest in three dimensional geometries
Authors: Palacio‐Betancur Viviana , Villada‐Gil Stiven , de Pablo Juan J. , Hernández‐Ortiz Juan P. 
Published: September 2016

SummaryWe present a novel methodology to effectively localize radial basis function approximation methods in three dimensions. The local scheme requires shape parameter‐dependent functions that can be used to approximate gradients of scattered data and to solve partial differential operators. The optimum shape parameter is obtained from the highest gradient of interest, where a known analytical function, when boundary conditions are not present, or a shape parameter‐free global approximation are used to educate the localized scheme. The later option is applicable to problems where the operator needs to be solved multiple times, like in time evolution or stochastic integration. Past shape parameter's optimizations, for two‐dimensional domains, based on the condition number of the interpolant matrix, were unable to provide satisfactory approximations. The applicability of our method is illustrated in the context of an analytical expression interpolation and during a Ginzburg–Landau relaxation of a free energy functional. In general, the optimum shape parameter depends on geometry, node distribution, and density, whereas the approximation errors decrease as the node density and the local stencil size increase. The effective localization of radial basis functions motivates its use in moving boundary problems and accelerates solutions through sparse matrix solvers. Copyright © 2016 John Wiley & Sons, Ltd.
Nitsche's method for Helmholtz problems with embedded interfaces
Authors: Zou Zilong , Aquino Wilkins , Harari Isaac 
Published: September 2016

SummaryIn this work, we use Nitsche's formulation to weakly enforce kinematic constraints at an embedded interface in Helmholtz problems. Allowing embedded interfaces in a mesh provides significant ease for discretization, especially when material interfaces have complex geometries. We provide analytical results that establish the well‐posedness of Helmholtz variational problems and convergence of the corresponding finite element discretizations when Nitsche's method is used to enforce kinematic constraints. As in the analysis of conventional Helmholtz problems, we show that the inf‐sup constant remains positive provided that the Nitsche's stabilization parameter is judiciously chosen. We then apply our formulation to several 2D plane‐wave examples that confirm our analytical findings. Doing so, we demonstrate the asymptotic convergence of the proposed method and show that numerical results are in accordance with the theoretical analysis. Copyright © 2016 John Wiley & Sons, Ltd.
Separation of phenanthrene/N‐tetradecane mixtures (model diesel) via pervaporation using an aromatic polyimide membrane
Authors: Roychowdhury Sayan , Mitra Debarati 
Published: September 2016

The present investigation focuses on the separation of phenanthrene (a polyaromatic hydrocarbon) from n‐tetradecane (model diesel composition) via pervaporation using a fabricated aromatic polyimide membrane. The experiments demonstrate preferential permeation of the polyaromatic for all films within the studied experimental range. The influence of operating temperature, membrane pretreatment time, membrane composition, and membrane thickness on the pervaporative performance were investigated. Statistical software Design Expert 7.1.4 was used to derive the regression equation describing the effect of the above mentioned factors on the pervaporation separation index. These factors are optimized using response surface methodology. The highest value of pervaporation separation index obtained is 1.5277 kg m−2 h−1 and the corresponding optimized condition is: operating temperature 493 K, pretreatment time 16.55 h with a membrane composition of 2.76 wt% of phenanthrene in polyamic acid and thickness 53.22 µm. POLYM. ENG. SCI., 57:392–402, 2017. © 2016 Society of Plastics Engineers
Time‐dependent calculations on systems of chemical interest: Dynamical and kinetic approaches
Authors: Skouteris Dimitrios 
Published: September 2016

AbstractWe illustrate the state of the art in time‐dependent calculations on systems of chemical interest. In particular, our exposition covers the Gaussian multiconfiguration time‐dependent Hartree/variational multiconfiguration Gaussian approach in nuclear dynamics, where the scope is that of explaining dynamical effects in various physicochemical processes. Conversely, the Rice–Ramsperger–Kassel–Marcus/master equation kinetic methods are also examined, used to calculate rate constants of gas phase processes (used in the modeling of combustion, atmospheric, and astrochemical processes).
Robust output‐control for uncertain linear systems: Homogeneous differentiator‐based observer approach
Authors: Ríos H. , Mera M. , Efimov D. , Polyakov A. 
Published: September 2016

SummaryThis paper deals with the design of a robust control for linear systems with external disturbances using a homogeneous differentiator‐based observer based on a implicit Lyapunov function approach. Sufficient conditions for stability of the closed‐loop system in the presence of external disturbances are obtained and represented by linear matrix inequalities. The parameter tuning for both controller and observer is formulated as a semi‐definite programming problem with linear matrix inequalities constraints. Simulation results illustrate the feasibility of the proposed approach and some improvements with respect to the classic linear observer approach. Copyright © 2016 John Wiley & Sons, Ltd.
Efficacy of remote telemetry data loggers for landscape‐scale monitoring: A case study of American martens
Authors: Sirén Alexej P. K. , Maynard Daniel S. , Kilborn Jillian R. , Pekins Peter J. 
Published: September 2016

ABSTRACTRemote telemetry data loggers are commonly used for monitoring wildlife species. Although remote telemetry data loggers provide reliable microhabitat use data, few studies have used them to evaluate landscape‐scale, temporal, and spatial habitat use. We installed 3 data loggers along a mountain ridgeline that was being developed for a commercial wind farm in northern New Hampshire, USA, to monitor use of a high‐elevation forest by American martens (Martes americana). We tested 1) the efficacy of data loggers to record presence–absence and index space use in a 6.75‐km2 area, validating marten locations using radiotelemetry and camera traps; and 2) whether there were diel and seasonal biases of data logger detections. As a case study, we evaluated temporal and spatial habitat‐use hypotheses with respect to variations in vegetation cover (leaf‐on or leaf‐off) and astronomical seasons using data from 11 martens monitored for nearly 2 years (6 Feb 2011–23 Dec 2012). Data loggers recorded presence–absence of radiocollared martens across 80% (240 of 299) of the trials within the study area with few false positives (4%; 19 of 494 trials). Detection probability and spatial use were most influenced by elevation, distance to data loggers, and line‐of‐sight view. We did not detect a seasonal bias but data loggers recorded fewer nocturnal detections. We recorded 118,120 detections of radiocollared martens, most of which occurred during leaf‐off seasons (87%; 102,931). Spatial use declined significantly (β = −0.54, P = 0.04) during the first leaf‐on season, corresponding with the construction phase of the wind farm project, and remained lower throughout the study. Diel use was explained by an astronomical calendar with greater nocturnal use during autumn and winter. Our results show that remote telemetry data loggers provided accurate spatiotemporal data for landscape‐scale habitat monitoring, overcoming many of the problems with telemetry data—such as limited sampling period and bias—that can compromise measurements of space use. We suggest incorporating remote telemetry data loggers for space use and disturbance studies of wildlife species. © 2016 The Wildlife Society.
Comparison of treatment effort for immunocontraceptive vaccines and surgical sterilization in deer
Authors: Evans Charles S. , DeNicola Anthony J. , Warren Robert J. 
Published: September 2016

ABSTRACTFertility control via immunocontraceptive vaccines or surgical sterilization often is considered for the management of deer populations in urban–suburban communities in the United States. Immunocontraceptive vaccines have been approved for hand‐injection in deer and it has been suggested dart‐injection would be more efficient because of added effort associated with live capture. Vaccines currently exhibit nonresponder rates in deer and require booster shots in following years to prolong efficacy, whereas surgical sterilization has 100% efficacy for the entirety of the life of the individual. However, sterilization is considered less efficient because of additional person‐hours required during the first year of a project. Therefore, we recorded person‐hours required for the capture process (capture, search, and handling) for treating deer via hand‐injection and surgical sterilization during winter of 2013, 2014, or 2015 at sites in North Carolina, California, Maryland, New York, and Virginia, USA. These data were recorded for 335 deer across 6 urban–suburban communities. Capture effort consisted of pursuit (i.e., person‐hours to acquire shot opportunities) and search and handling (i.e., S&H; person‐hours to locate anesthetized deer and vaccinate the individual). On average, 91% and 9% of person‐hours were for pursuit and S&H, respectively. Surgical sterilization added an average of 153% to person‐hours required for the capture process; however, considering lower efficacy and retreatment requirements of vaccines, sterilization may be more efficient for long‐term control of deer in urban–suburban communities. Deer behavior varied across our 6 study sites and affected effort—more approachable deer required less effort to capture and treat with fertility control. Therefore, future research should include modelling deer behavior, effort, and efficacy over the long term to identify which situations are best suited for application of vaccine versus sterilization treatments in areas where lethal management of deer is impractical. © 2016 The Wildlife Society.
Trans10,cis15 18:2 Isolated from Beef Fat Does Not Have the Same Anti‐Adipogenic Properties as Trans10,cis12–18:2 in 3T3‐L1 Adipocytes
Authors: Vahmani Payam , Meadus William J. , Rolland David C. , Duff Pascale , Dugan Michael E. R. 
Published: September 2016

AbstractDuring ruminal biohydrogenation of α‐linolenic acid, a non‐conjugated non‐methylene interrupted dienoic acid is formed containing a t10 double bond, namely t10,c15–18:2. The present study was designed to examine whether t10,c15–18:2 would exert similar anti‐adipogenic effects compared to t10,c12–18:2 in 3T3‐L1 adipocytes. Differentiated 3T3‐L1 adipocytes were treated with 35 or 70 µM of LNA, t10,c12–18:2, t10,c15–18:2, or bovine serum albumin (BSA) vehicle control for 120 h. Cellular triacylglycerol and protein were quantified using commercial colorimetric kits. Cells were analyzed for fatty acid composition and gene expression using gas chromatography and quantitative PCR, respectively. Trans10,cis12–18:2 decreased (P < 0.05) the adipocyte triacylglycerol (TAG) content, which was mainly related to a reduction in saturated fatty acids (SFA; e.g., 16:0 and 15:0) and cis monounsaturated fatty acids (c‐MUFA; e.g., c9–16:1 and c9–18:1). Trans10,cis12 also decreased (P < 0.05) the expression of genes related to fatty acid synthesis (ACACA, FASN), delta‐9 desaturation (SCD1), fatty acid elongation (ELOVL5), and fatty acid uptake (LPL) and upregulated (P < 0.05) the expression of the rate‐liming enzyme involved in fatty acid β‐oxidation (CPT1). In contrast, LNA and t10,c15–18:2 did not affect the gene expression and cellular content of the TAG, SFA, c‐MUFA, or SCD1 indices in adipocytes. Our findings suggest that t10,c15–18:2, despite having structural similarity to t10,c12–18:2 (presence of a trans‐10 double bond), does not exert anti‐adipogenic effects in 3T3‐L1 adipocytes.
Item response theory analysis of the Pain Self-Efficacy Questionnaire
Authors: Costa Daniel S.J. , Asghari Ali , Nicholas Michael K. 
Published: September 2016

Abstract

Background and aims
The Pain Self-Efficacy Questionnaire (PSEQ) is a 10-item instrument designed to assess the extent to which a person in pain believes s/he is able to accomplish various activities despite their pain. There is strong evidence for the validity and reliability of both the full-length PSEQ and a 2-item version. The purpose of this study is to further examine the properties of the PSEQ using an item response theory (IRT) approach.

Methods
We used the two-parameter graded response model to examine the category probability curves, and location and discrimination parameters of the 10 PSEQ items. In item response theory, responses to a set of items are assumed to be probabilistically determined by a latent (unobserved) variable. In the graded-response model specifically, item response threshold (the value of the latent variable for which adjacent response categories are equally likely) and discrimination parameters are estimated for each item. Participants were 1511 mixed, chronic pain patients attending for initial assessment at a tertiary pain management centre.

Results
All items except item 7 (‘I can cope with my pain without medication’) performed well in IRT analysis, and the category probability curves suggested that participants used the 7-point response scale consistently. Items 6 (‘I can still do many of the things I enjoy doing, such as hobbies or leisure activity, despite pain’), 8 (‘I can still accomplish most of my goals in life, despite the pain’) and 9 (‘I can live a normal lifestyle, despite the pain’) captured higher levels of the latent variable with greater precision.

Conclusions
The results from this IRT analysis add to the body of evidence based on classical test theory illustrating the strong psychometric properties of the PSEQ. Despite the relatively poor performance of Item 7, its clinical utility warrants its retention in the questionnaire.

Implications
The strong psychometric properties of the PSEQ support its use as an effective tool for assessing self-efficacy in people with pain.
Point-of-use Unit Based on Gravity Ultrafiltration Removes Waterborne Gastrointestinal Pathogens from Untreated Water Sources in Rural Communities
Authors: Chaidez Cristóbal , Ibarra-Rodríguez Juan R. , Valdez-Torres José Benigno , Soto Marcela , Gerba Charles P. , Castro-del Campo Nohelia 
Published: September 2016

Objective In developing countries, rural communities often face the lack of potable water infrastructure and must rely on untreated sources for drinking, which are often contaminated with waterborne pathogens. The use of home water treatment devices is seen as one means of reducing the risk of exposure to waterborne pathogens. The aim of this study was to evaluate the microbiological and physicochemical performance of a simple in-home point-of-use device based on gravity ultrafiltration through an ultrafilter membrane. Methods Twenty-five randomly selected households from 2 rural communities in Culiacán, Mexico, were enrolled. Water samples were collected before and after treatment and during storage for a period of 8 weeks. Heterotrophic bacteria, total coliforms, fecal coliforms, Escherichia coli, and Giardia spp were quantified, as well as various physicochemical parameters. Results All of the untreated water samples contained high levels of indicator bacteria, but none were detected in the treated water fulfilling the requirements set by the Mexican Norm (NOM-127-SSA1-1994) and the World Health Organization guidelines for drinking water. However, indicator bacteria (fecal coliforms and E coli) were detected in every sample from water stored 24 hours after treatment. Conclusion This study demonstrated that point-of-use filters using gravity-fed ultrafilters are a low-cost, effective water treatment technology for water of poor microbial quality. However, further identification of the sources and mechanisms by which water is contaminated when stored after treatment will help with designing and implementing better strategies for keeping water safe for domestic use.