bluuebunny/crossref_metadata_2025_split huggingface dataset:
Post-fire carbon and nitrogen accumulation and succession in Central Siberia
Authors: Larjavaara Markku , Berninger Frank , Palviainen Marjo , Prokushkin Anatoly , Wallenius Tuomo 
Published: October 2017

AbstractImproved understanding of carbon (C) accumulation after a boreal fire enables more accurate quantification of the C implications caused by potential fire regime shifts. We coupled results from a fire history study with biomass and soil sampling in a remote and little-studied region that represents a vast area of boreal taiga. We used an inventory approach based on predefined plot locations, thus avoiding problems potentially causing bias related to the standard chronosequence approach. The disadvantage of our inventory approach is that more plots are needed to expose trends. Because of this we could not expose clear trends, despite laborious sampling. We found some support for increasing C and nitrogen (N) stored in living trees and dead wood with increasing time since the previous fire or time since the previous stand-replacing fire. Surprisingly, we did not gain support for the well-established paradigm on successional patterns, beginning with angiosperms and leading, if fires are absent, to dominance of Picea. Despite the lack of clear trends in our data, we encourage fire historians and ecosystem scientists to join forces and use even larger data sets to study C accumulation since fire in the complex Eurasian boreal landscapes.
Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics
Authors: Shiromizu Takashi , Kume Hideaki , Ishida Mimiko , Adachi Jun , Kano Masayuki , Matsubara Hisahiro , Tomonaga Takeshi 
Published: October 2017

AbstractAt the moment, there is no sensitive clinical test for detecting early-stage colorectal cancer (CRC). Target proteomics has enabled high-throughput verification of hundreds of biomarker candidate proteins. Using this technology, we verified 725 previously reported CRC biomarker candidate proteins that are functionally correlated with CRC in extracellular vesicles (EVs) from patients. Of these, 356 proteins were quantified, and 34 peptides (22 proteins) showed significant differences in the serum EVs between healthy controls and CRC patients of two independent cohorts (n = 77 and 84). These peptides were evaluated as single or multiple markers, and four single peptides in annexin family proteins and eight combinations of peptides showed area under the curve > 0.9 for discriminating between healthy controls and CRC patients. The sensitivities of annexins A3, A4, and A11 peptides for detecting early-stage CRC greatly exceed those of carcinoembryonic antigen. These peptides are promising biomarkers for early detection of CRC.
1700 nm and 1800 nm band tunable thulium doped mode-locked fiber lasers
Authors: Emami Siamak Dawazdah , Dashtabi Mahdi Mozdoor , Lee Hui Jing , Arabanian Atoosa Sadat , Rashid Hairul Azhar Abdul 
Published: October 2017

AbstractThis paper presents short wavelength operation of tunable thulium-doped mode-locked lasers with sweep ranges of 1702 to 1764 nm and 1788 to 1831 nm. This operation is realized by a combination of the partial amplified spontaneous emission suppression method, the bidirectional pumping mechanism and the nonlinear polarization rotation (NPR) technique. Lasing at emission bands lower than the 1800 nm wavelength in thulium-doped fiber lasers is achieved using mode confinement loss in a specially designed photonic crystal fiber (PCF). The enlargement of the first outer ring air holes around the core region of the PCF attenuates emissions above the cut-off wavelength and dominates the active region. This amplified spontaneous emission (ASE) suppression using our presented PCF is applied to a mode-locked laser cavity and is demonstrated to be a simple and compact solution to widely tunable all-fiber lasers.
Identification of Two Tobacco rattle virus Variants Associated with Line Pattern Disease of Bleeding Heart in Ohio
Authors: Fisher John R. 
Published: October 2017

Tobacco rattle virus (TRV) is a member of the Tobravirus genus and has a broad host range including weeds, vegetables, and ornamentals. Several bleeding heart (Lamprocapnos spectabilis) plants showing a yellow line pattern symptom were negative for the Potyvirus group, Alfalfa mosaic, Arabis mosaic, Cucumber mosaic, Impatiens necrotic spot, Tobacco mosaic, Tobacco ringspot, Tomato ringspot, and Tomato spotted wilt viruses by ELISA. cDNAs synthesized from dsRNA template and immunocaptured virions from symptomatic and asymptomatic bleeding heart amplified clear products with Tobravirus group and TRV specific primers targeted at regions in the 194 kDa open reading frame 1 on RNA 1. Cloned amplicon sequences demonstrated two distinct populations of sequences for both primer pairs and the two populations correlated with symptoms, or lack thereof, on bleeding heart. These results represent the first confirmed report of TRV associated with line pattern disease on bleeding heart in Ohio. Accepted for publication 19 December 2012. Published 25 March 2013.
Screening Selected Gulf Coast and Southeastern Forest Species for Susceptibility to Phytophthora ramorum
Authors: Preuett Jason A. , Collins Daniel J. , Luster Douglas , Widmer Timothy L. 
Published: October 2017

Phytophthora ramorum, the causal agent of sudden oak death, poses a threat to woody plants in the rest of the United States. Several plant species native to Gulf Coast and southeastern US forests were tested for reaction to P. ramorum, including eastern baccharis (Baccharis halmifolia), spicebush (Lindera benzoin), yaupon (Ilex vomitoria), southern magnolia (Magnolia grandiflora), sweetbay magnolia (M. virginiana), Virginia creeper (Parthenocissus quinquefolia), black willow (Salix nigra), and baldcypress (Taxodium distichum). The foliage of each species was inoculated with a zoospore suspension and placed in a dew chamber for 5 days. The average percentage of leaf area necrosis was 0.2, 4.9, 27.9, 32.1, 8.6, 1.5, 1.1, 0.2, and 5.0% for inoculated eastern baccharis, spicebush, yaupon, southern magnolia, sweetbay magnolia, Virginia creeper (Louisiana), Virginia creeper (Maryland), black willow, and baldcypress, respectively. Comparison of the percent necrotic leaf area between inoculated and non-inoculated plants showed significant differences (P ≤ 0.05) for yaupon (P = 0.0008), southern magnolia (P = 0.001), and sweetbay magnolia (P = 0.0009). The other species did not show significant differences although infection was confirmed on spicebush, Virginia creeper, and baldcypress. This is a first report of yaupon, sweetbay magnolia, and baldcypress being hosts of P. ramorum. Accepted for publication 2 April 2013. Published 30 July 2013.
Comparison of Seed Transmission and Survival of Xanthomonas axonopodis pv. phaseoli and Xanthomonas fuscans subsp. fuscans in Common Bean Seeds
Authors: He Y. , Munkvold G. P. 
Published: October 2017

Xanthomonas axonopodis pv. phaseoli (Smith) Vauterin (Xap) and Xanthomonas fuscans subsp. fuscans Schaad et al. (Xff) cause indistinguishable symptoms known as common bacterial blight of bean (Phaseolus vulgaris L.). These results confirm a higher disease incidence and seed transmission frequency of Xff compared to Xap and reinforce the need for seed health tests that can differentiate the two species. Accepted for publication 21 August 2013. Published 23 September 2013.
The 12th I. E. Melhus Graduate Student Symposium: Host Plant Resistance and Disease Management, Current Status, and Future Outlook
Authors: Kousik C. S. 
Published: October 2017

The 12th I. E. Melhus Graduate Student Symposium was held at the 2012 annual meeting of the American Phytopathological Society in Providence, RI. Its theme was “Host Plant Resistance and Disease Management: Current Status and Future Outlook.” The symposium featured four graduate student presentations highlighting research that leads to a better understanding of host plant resistance, resistance breeding, and disease management. Accepted for publication 6 November 2013. Published 25 November 2013.
Dispatcher-Assisted Telephone Cardiopulmonary Resuscitation Using a French-Language Compression-Ventilation Pediatric Protocol
Authors: Peters Michael , Stipulante Samuel , Delfosse Anne-Sophie , Schumacher Katarina , Mulder André , Lebrun Frédéric , Donneau Anne-Françoise , Ghuysen Alexandre 
Published: October 2017

Objective
Out-of-hospital cardiac arrest (OHCA) in pediatrics is a devastating event associated with poor survival rates. Although telephone dispatcher-assisted cardiopulmonary resuscitation (CPR; T-CPR) instructions improve the frequency and quality of bystander CPR for OHCA in adults, this support remains undeveloped in children. Our objective was to assess the effectiveness of a pediatric T-CPR protocol in untrained and trained bystanders. Secondarily, we sought to determine the feasibility and the effectiveness of ventilation in such a protocol.

Methods
Eligible adults with no CPR experience were recruited in a movie theater in Liege, as well as bachelor nursing students in Liege. All volunteers were randomly assigned either to T-CPR or to no–T-CPR using randomization. The volunteers were exposed to a pediatric manikin model cardiac arrest. On the basis of Cardiff evaluation test, data were collected to evaluate CPR performance.

Results
A total of 115 volunteers were assigned to 4 groups: untrained nonguided group (n = 27), untrained guided group (n = 32), trained nonguided group (n = 26), and trained guided group (n = 30). We found an improvement in CPR performance in the guided groups. Most volunteers (81.2%) in untrained guided group and 83.3% in the trained guided group were able to give 2 ventilations after each compressions cycle.

Conclusions
In a pediatric manikin model of OHCA, T-CPR instructions including mouth-to-mouth ventilations and chest compressions produced a significant increase in resuscitation performance not only among previously untrained but also among trained volunteers.
How is structural divergence related to evolutionary information?
Authors: Zea Diego Javier , Monzon Alexander Miguel , Parisi Gustavo , Marino-Buslje Cristina 
Published: October 2017

AbstractConservation and covariation measures, as other evolutionary analysis, require a high number of distant homologous sequences, therefore a lot of structural divergence can be expected in such divergent alignments. However, most works linking evolutionary and structural information use a single structure ignoring the structural variability inside a protein family. That common practice seems unrealistic to the light of this work.In this work we studied how structural divergence affects conservation and covariation estimations. We uncover that, within a protein family, ~51% of multiple sequence alignment columns change their exposed/buried status between structures. Also, ~53% of residue pairs that are in contact in one structure are not in contact in another structure from the same family. We found out that residue conservation is not directly related to the relative solvent accessible surface area of a single protein structure. Using information from all the available structures rather than from a single representative structure gives more confidence in the structural interpretation of the evolutionary signals. That is particularly important for diverse multiple sequence alignments, where structures can drastically differ. High covariation scores tend to indicate residue contacts that are conserved in the family, therefore, are not suitable to find protein/conformer specific contacts.Our results suggest that structural divergence should be considered for a better understanding of protein function, to transfer annotation by homology and to model protein evolution.
Relating C-reactive Protein to Psychopathology after Cardiac Surgery and Intensive Care Unit Admission: A Mendelian Randomization Study
Authors: Kok Lotte , Lin Bochao Danae , Broersen Juliette , Bekema Erwin , Medic Jelena , van Eijk Kristel R , Hillegers Manon H , Veldhuijzen Dieuwke S , Luykx Jurjen J 
Published: October 2017

AbstractPatients admitted to an intensive care unit (ICU) are subjected to a high burden of stress, rendering them prone to develop stress-related psychopathology. Dysregulation of inflammation and, more specifically, upregulation of inflammatory markers such as C-reactive protein (CRP) is potentially key in development of post-ICU psychopathology.To investigate the effects of state-independent CRP on symptoms of post-traumatic stress disorder (PTSD) and depression after ICU admission, we analysed the three leading single nucleotide polymorphisms (SNPs) of loci most strongly associated with blood CRP levels (i.e. rs2794520, rs4420638, and rs1183910) in an ICU survivor cohort. Genetic association was estimated by linear and logistical regression models of individual SNPs and genetic risk score (GRS) profiling. Mendelian Randomization (MR) was used to investigate potential causal relationships.Single-SNP analyses were non-significant for both quantitative and binary trait analyses after correction for multiple testing. In addition, GRS results were non-significant and explained little variance in psychopathology. Moreover, MR analysis did not reveal any causality and MR-Egger regression showed no evidence of pleiotropic effects (p-pleiotropy >0.05). Furthermore, estimation of causality between these loci and other psychiatric disorders was similarly non-significant.In conclusion, by applying a range of statistical models we demonstrate that the strongest plasma CRP-influencing genetic loci are not associated with post-ICU PTSD and depressive symptoms. Our findings add to an expanding body of literature on the absence of associations between trait CRP and neuropsychiatric phenotypes.
Exchange protein directly activated by cAMP plays a critical role in regulation of vascular fibrinolysis
Authors: He Xi , Drelich Aleksandra , Chang Qing , Gong Dejun , Zhou Yixuan , Qu Yue , Yu Shangyi , Yuan Yang , Qian Jiao , Qiu Yuan , Tang Shao-Jun , Gaitas Angelo , Ksiazek Thomas , Xu Zhiyun , Wakamiya Maki , Lu Fanglin , Gong Bin 
Published: October 2017

AbstractRationaleTo maintain vascular patency, endothelial cells (ECs) actively regulate hemostasis. Among the myriad of pathways by which they control both fibrin formation and fibrinolysis is EC expression of annexin A2 (ANXA2) in a heterotetrameric complex with S100A10 [(ANXA2-S100A10)2]. This complex is a well-recognized endothelial surface platform for the activation of plasminogen by tissue plasminogen activator. A noteworthy advance in this field came about when it was shown that the cAMP pathway is linked to the regulation of (ANXA2-S100A10)2in ECs.ObjectiveThese findings prompted us to determine whether a druggable target, namely the exchangeprotein directlyactivated bycAMP (EPAC) pathway, plays a role in vascular luminal fibrinolysis.Methods and ResultsTaking advantage of our Epac1-null mouse model, we found that depletion ofEpac1results in fibrin deposition, fibrinolytic dysfunction, and decreased endothelial surface ANXA2 in mice, which are similar to phenomena discovered inANXA2-null andS100A10-null mice. We observed upregulation of EPAC1 and downregulation of fibrin in endocardial tissues beneath atrial mural thrombi in humans. Of note, our thrombosis model revealed that dysfunction of fibrinolysis inEPAC1-null mice can be ameliorated by recombinant ANXA2. Furthermore, we demonstrated that suppression of EPAC1 using a small-molecule inhibitor (ESI09) reduces the expression of ANXA2 in lipid rafts and impedes ANXA2 association with S100A10. Endothelial apical surface expression of both ANXA2 and S100A10 were markedly decreased in ESI09-treated ECs, which was corroborated by results from a nanoforce spectroscopy study. Moreover, inactivation of EPAC1 decreases tyrosine 23 phosphorylation of ANXA2 in the cell membrane compartment.ConclusionsOur data reveal a novel role for EPAC1 in vascular fibrinolysis, by showing that EPAC1 is responsible for the translocation of ANXA2 to the EC surface. This process promotes conversion of plasminogen to plasmin, thereby enhancing local fibrinolytic activity.
The relationship between universal network perceptions and dyadic network perceptions and their effect on employees’ behavioral reactions to organizational change
Authors: Hatjidis Dimitrios , Parker Andrew 
Published: October 2017

PurposeThe purpose of this paper is to examine empirically the relationships formed between the universal network quality perceptions and the dyadic network quality perceptions that an individual formulate through social ties at work and their effect on behavioral reaction toward organizational change.Design/methodology/approachThe data were collected from 91 full-time hotel employees through a self-report survey. Using regression models and mediation method three hypotheses referring to the relationship between the universal and the dyadic perceptions as well as the indirect effect of the dyadic network perception on behavioral reactions to change, through universal network perceptions, are tested.FindingsThe results show that universal network perception has a positive association with an individual’s behavior toward change, while the authors’ dyadic network perception hypothesis is not supported. Additional results highlight the indirect effect of dyadic network perception on behavioral reactions to change through universal network perceptions.Research limitations/implicationsOwing to the nature of the study, the inferences of causality might not be that strong as the authors’ findings are limited to the fact that the outcome variable is the behavioral intention toward a hypothetical organizational change rather than an actual change.Practical implicationsAlthough both types of perceptions are needed in affecting behavioral intentions, the universal network perceptions are the ones that need to be considered as indicators of the need for proactive non-conventional management planning with regard to the human element of change management.Originality/valueThe principal contribution of this study is that it brings greater clarity to how tie quality perceptions are constructed and their impact on employees’ behavior toward organizational change.
A posterioridietary patterns and risk of pancreatic and renal cancers
Authors: Alizadeh Shahab , Shab-Bidar Sakineh , Mohtavinejad Nasser , Djafarian Kurosh 
Published: October 2017

PurposeDietary patterns have been used to explore the association between dietary factors and risk of pancreatic cancer (PC) and renal cancer (RC); however, the association remains unclear. The purpose of this paper is to comprehensively review these associations.Design/methodology/approachPertinent studies published prior to March 2016 were systematically searched and retrieved through PubMed and Scopus databases. Adjusted risk estimates were derived by comparing the highest with the lowest categories of dietary pattern scores and were combined by using the fixed-effects model when no substantial heterogeneity was observed; otherwise, the random-effects model was used.FindingsA total of nine studies, five for PC (including 2,059 cases and 41,774 participants/controls) and four for RC (with 1,327 cases and 53,007 participants/controls), were included in this meta-analysis. A decreased risk of PC was shown for the highest compared with the lowest categories of the healthy dietary pattern (OR = 0.72, 95 per cent CI = 0.51-0.94, random effects (p-value for heterogeneity = 0.004)), whereas no significant association with Western dietary was observed (OR = 1.16, 95 per cent CI = 0.87-1.44, fixed effects). In the overall analysis, a significant association was found between the healthy dietary pattern and reduced risk of RC (OR = 0.59, 95 per cent CI = 0.48-0.71, fixed effects (p-value for heterogeneity = 0.459)), whereas the Western pattern was positively associated with risk of RC (OR = 1.42, 95 per cent CI = 1.14-1.69, fixed effects). For both cancers, the reduced risk associated with the healthy pattern was restricted to case-control, but not cohort, studies. Furthermore, drinking pattern was significantly related to reduced risk of RC (OR = 0.68, 95 per cent CI = 0.42-0.94).Originality/valueTo the authors’ knowledge, the present study is the first English document to summarize systematically the findings from observational studies in response to this question whethera posterioridietary patterns are associated with susceptibility to the risk of renal and ovarian cancers.
Making meaning out of noise
Authors: Cegarra-Sánchez Jorge , Cegarra-Navarro Juan-Gabriel 
Published: October 2017

PurposeThe environments provided by classrooms to facilitate learning among students can be seen as useful vehicles for making meaning out of gossip, lies, exaggeration and partial truths (i.e. counter-knowledge). This paper aims to focus on professional learning communities as a process to counteract the problem of counter-knowledge.Design/methodology/approachThis paper has analysed the relationships between professional-learning communities and counter-knowledge using an empirical study of 210 undergraduate students to identify whether there is a significant impact on student achievement by professional learning communities. This study uses PLS-Graph software version 3.0 to conduct an analysis of the data collected.FindingsOutcome findings support that professional learning communities provide a way of counteracting counter-knowledge and the noise heard through gossip, lies, exaggeration and partial truths.Originality/valueResults also confirm that counter-knowledge is a variable that, when controlled, has the effect of strengthening the relationship between learning and student achievement.
The nitrate‐reduction gene cluster components exert lineage‐dependent contributions to optimization of Sinorhizobium symbiosis with soybeans
Authors: Liu Li Xue , Li Qin Qin , Zhang Yun Zeng , Hu Yue , Jiao Jian , Guo Hui Juan , Zhang Xing Xing , Zhang Biliang , Chen Wen Xin , Tian Chang Fu 
Published: October 2017

SummaryReceiving nodulation and nitrogen fixation genes does not guarantee rhizobia an effective symbiosis with legumes. Here, variations in gene content were determined for three Sinorhizobium species showing contrasting symbiotic efficiency on soybeans. A nitrate‐reduction gene cluster absent in S. sojae was found to be essential for symbiotic adaptations of S. fredii and S. sp. III. In S. fredii, the deletion mutation of the nap (nitrate reductase), instead of nir (nitrite reductase) and nor (nitric oxide reductase), led to defects in nitrogen‐fixation (Fix–). By contrast, none of these core nitrate‐reduction genes were required for the symbiosis of S. sp. III. However, within the same gene cluster, the deletion of hemN1 (encoding oxygen‐independent coproporphyrinogen III oxidase) in both S. fredii and S. sp. III led to the formation of nitrogen‐fixing (Fix+) but ineffective (Eff–) nodules. These Fix+/Eff– nodules were characterized by significantly lower enzyme activity of glutamine synthetase indicating rhizobial modulation of nitrogen‐assimilation by plants. A distant homologue of HemN1 from S. sojae can complement this defect in S. fredii and S. sp. III, but exhibited a more pleotropic role in symbiosis establishment. These findings highlighted the lineage‐dependent optimization of symbiotic functions in different rhizobial species associated with the same host.