bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vascular thiol isomerases
Authors: Flaumenhaft Robert , Furie Bruce 
Published: June 2016

AbstractThiol isomerases are multifunctional enzymes that influence protein structure via their oxidoreductase, isomerase, and chaperone activities. These enzymes localize at high concentrations in the endoplasmic reticulum of all eukaryotic cells where they serve an essential function in folding nascent proteins. However, thiol isomerases can escape endoplasmic retention and be secreted and localized on plasma membranes. Several thiol isomerases including protein disulfide isomerase, ERp57, and ERp5 are secreted by and localize to the membranes of platelets and endothelial cells. These vascular thiol isomerases are released following vessel injury and participate in thrombus formation. Although most of the activities of vascular thiol isomerases that contribute to thrombus formation are yet to be defined at the molecular level, allosteric disulfide bonds that are modified by thiol isomerases have been described in substrates such as αIIbβ3, αvβ3, GPIbα, tissue factor, and thrombospondin. Vascular thiol isomerases also act as redox sensors. They respond to the local redox environment and influence S-nitrosylation of surface proteins on platelets and endothelial cells. Despite our rudimentary understanding of the mechanisms by which thiol isomerases control vascular function, the clinical utility of targeting them in thrombotic disorders is already being explored in clinical trials.
RETRACTED ARTICLE: MicroRNA-130b promotes lung cancer progression via PPARγ/VEGF-A/BCL-2-mediated suppression of apoptosis
Authors: Tian Jianwei , Hu Liping , Li Xiao , Geng Jian , Dai Meng , Bai Xiaoyan 
Published: June 2016

Abstract
Background
The prognosis of non-small-cell lung cancer (NSCLC) is poor yet mechanistic understanding and therapeutic options remain limited. We investigated the biological and clinical significance of microRNA-130b and its relationship with apoptosis in NSCLC.

Methods
The level of microRNA-130b in relationship with the expression of PPARγ, VEGF-A, BCL-2 and apoptosis were analyzed in 91 lung cancer patient samples using immunohistochemistry and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay on tissue microarrays. Gain and loss-of-function studies were performed to investigate the effects of microRNA-130b, peroxisome proliferator-activated receptor γ (PPARγ) or vascular endothelial growth factor-A (VEGF-A) on biological functions of lung cancer cells using in vitro and in vivo approaches.

Results
MicroRNA-130b up-regulation conferred unfavorable prognosis of lung cancer patients. Notably, microRNA-130b targeted PPARγ and inhibiting microRNA-130b markedly repressed proliferation, invasion and metastasis of lung cancer cells, leading to increased apoptosis. MicroRNA-130b-dependent biologic effects were due to suppression of PPARγ that in turn activated BCL-2, the key mediator of anti-apoptosis. Administration of microRNA-130b mimic to mouse xenografts promoted tumor growth. In vitro and in vivo, miR-130b enrichment associated with down-regulation of PPARγ, up-regulation of VEGF-A and BCL-2, and decreased apoptosis.

Conclusions
The present study demonstrates that microRNA-130b promotes lung cancer progression via PPARγ/VEGF-A/BCL-2-mediated suppression of apoptosis. Targeting microRNA-130b might have remarkable therapeutic potential for lung cancer therapy.
Circulating Cytokines Predict the Development of Insulin Resistance in a Prospective Finnish Population Cohort
Authors: Santalahti Kristiina , Maksimow Mikael , Airola Antti , Pahikkala Tapio , Hutri-Kähönen Nina , Jalkanen Sirpa , Raitakari Olli T. , Salmi Marko 
Published: June 2016

Abstract

Context:
Metabolic inflammation contributes to the development of insulin resistance (IR), but the roles of different inflammatory and other cytokines in this process remain unclear.

Objective:
We aimed at analyzing the value of different cytokines in predicting future IR.

Design, Setting, and Participants:
We measured the serum concentrations of 48 cytokines from a nationwide cohort of 2200 Finns (the Cardiovascular Risk in Young Finns Study), and analyzed their role as independent risk factors for predicting the development of IR 4 years later.

Main Outcome Measures:
We used cross-sectional regression analysis adjusted for known IR risk factors (high age, body mass index, systolic blood pressure, triglycerides, smoking, physical inactivity, and low high-density lipoprotein cholesterol), C-reactive protein and 37 cytokines to find the determinants of continuous baseline IR (defined by homeostatic model assessment). A logistic regression model adjusted for the known risk factors, baseline IR, and 37 cytokines was used to predict the future IR.

Results:
Several cytokines, often in a sex-dependent manner, remained as independent determinants of current IR. In men, none of the cytokines was an independent predictive risk marker of future IR. In women, in contrast, IL-17 (odds ratio, 1.42 for 1-SD change in ln-transformed IL-17) and IL-18 (odds ratio, 1.37) were independently associated with the future IR. IL-17 levels also independently predicted the development of incident future IR (odds ratio, 1.48).

Conclusions:
The systemic levels of the T helper 1 cell cytokine IL-18 and the T helper 17 cell cytokine IL-17 thus may have value in predicting future insulin sensitivity in women independently of classical IR risk factors.
Investigação epidemiológica do primeiro caso de hantavirose no estado do Rio de Janeiro, Brasil<br>Epidemiological investigation of the first case of hantaviruses in the state of Rio de Janeiro, Brazil
Authors: Vargas Alexander , Da Nóbrega Martha Elizabeth Brasil , Fonseca Lidsy Ximenes , Oliveira Stefan Vilges de , Pereira Simone Valeria Costa , De Caldas Eduardo Pacheco , Saad Eduardo 
Published: June 2016

Introdução: A hantavirose é uma zoonose aguda, transmitida pela inalação de aerossóis formados a partir de excretas de roedores silvestres. A Síndrome Cardiopulmonar por Hantavírus (SCPH) é a forma clínica identificada no Brasil e apresenta elevada letalidade. Objetivo: Descrever a investigação epidemiológica de hantavirose no Estado do Rio de Janeiro (RJ), município de Rio Claro. Métodos: Foi realizado um estudo descritivo no período de fevereiro a maio de 2015. As informações obtidas foram provenientes do sistema de vigilância epidemiológica municipal e dos prontuários da assistência médica hospitalar. Resultados: Foi confirmado um óbito por hantavirose, indivíduo do sexo masculino, 34 anos, trabalhador rural que apresentou febre, cefaleia e mialgia, progredindo com sintomas respiratórios, digestivos, hipotensão além de gradual hemoconcentração e plaquetopenia, vindo a óbito seis dias após o início dos sintomas. Na investigação de 9.898 prontuários, foram identificados 46 indivíduos como casos suspeitos; destes, 31 foram submetidos à entrevista e à coleta de amostras clínicas. A análise sorológica detectou quatro indivíduos IgG reagentes, com exposições similares ao do óbito relatado. Conclusão. É registrado o primeiro caso de hantavirose no Estado do RJ, município de Rio Claro, bem como a detecção de indivíduos soro-reagentes, com clínica compatível e expostos a fatores de risco para a doença. Estes achados corroboram para a afirmativa da circulação prévia de hantavirose nessa região.
Η συμβολή των Σχολείων Δεύτερης Ευκαιρίας στο συμβολικό κεφάλαιο των εκπαιδευομένων
Authors: Ασημάκη ΄Αννυ , Κυριαζοπούλου Εύα , Βεργίδης Δημήτρης 
Published: June 2016

<p align="center">Σκοπός της παρούσας εργασίας<strong> </strong>είναι να διερευνηθούν οι προσδοκίες των εκπαιδευόμενων στο Σχολείο Δεύτερης Ευκαιρίας (Σ.Δ.Ε.), υπό την οπτική της ανταπόκρισης στους διακηρυγμένους στόχους του εκπαιδευτικού θεσμού, σε σχέση με τα κοινωνικο-οικονομικά οφέλη κατά την περίοδο της οικονομικής κρίσης στην Ελλάδα, μετά την απόκτηση του «τίτλου» σπουδών τους. Η εργασία αξιοποιεί τις έννοιες του πεδίου, του θεσμοποιημένου κεφαλαίου και του συμβολικού κεφαλαίου από το θεωρητικό σχήμα του Pierre Bourdieu. Η συλλογή των δεδομένων έγινε με τη χρήση 14 ημι-δομημένων συνεντεύξεων και η επεξεργασία τους με ποιοτική ανάλυση περιεχομένου. Τα ερευνητικά μας ευρήματα κατέδειξαν ότι οι εκπαιδευόμενοι από τη μια πλευρά κατανοούν την αναγκαιότητα της πρόσκτησης του θεσμοποιημένου κεφαλαίου το οποίο θα τους εξασφαλίσει το δικαίωμα εισόδου στο πεδίο εργασίας και τη βελτίωση της οικονομικής τους κατάστασης, από την άλλη πλευρά ωστόσο, φάνηκε ότι αντιμετωπίζουν τον τίτλο σπουδών ως ένα ανίσχυρο διακύβευμα για την πραγματοποίηση των προσδοκιών τους. Έτσι, επενδύουν στη μετατρεψιμότητα του θεσμοποιημένου κεφαλαίου τους σε συμβολικό κεφάλαιο, ευελπιστώντας ότι μπορεί εν δυνάμει, να τους αποφέρει κέρδη.</p><p> </p><p> </p>
Decline and local extinction of Fucales in French Riviera: the harbinger of future extinctions?
Authors: THIBAUT T. , BLANFUNE A. , BOUDOURESQUE C.-F. , VERLAQUE M. 
Published: June 2016

The French Riviera is one of the Mediterranean areas that has been longest and most thoroughly impacted by human activities. Fucales are long-lived, large-sized brown algae that constitute a good model for studying human impact on species diversity. We gathered all historical data (literature and herbarium vouchers), since the early 19th century, to reconstruct their distribution. The current distribution was established from a 7-year (2007-2013) survey of the 212-km shoreline (1/2 500 map), by means of boating, snorkelling and scuba diving. Overall, 18 taxa of Cystoseira and Sargassum have been reported. Upon comparison with historical data, 5 taxa were no longer observed (C. elegans, C. foeniculacea f. latiramosa, C. squarrosa, C. spinosa var. spinosa and S. hornschuchii) while C. jabukae, previously unrecorded, was observed. In addition to these taxa, probably extinct at a local scale, some taxa had suffered a dramatic decline (C. barbata f. barbata, C. crinita, C. spinosa var. compressa and S. acinarium) or become nearly extinct (C. foeniculacea f. tenuiramosa). Three of them, which played in the past significant functional roles in coastal communities, can be considered as functionally extinct. Possible causes of decline and local extinction are discussed. A similar situation has already been reported, although at a much more local scale, in a variety of Mediterranean localities. The question therefore arises about the status of Fucales species in the Mediterranean: are some species on the brink of extinction? Is their extinction at the scale of the French Riviera the harbinger of their extinction Mediterranean–wide?
Age, Growth and Reproduction of Coryphaena hippurus (Linnaeus, 1758) in Maltese Waters, Central Mediterranean
Authors: GATT M. , DIMECH M. , SCHEMBRI P. J. 
Published: June 2016

Age, growth and reproduction of the dolphinfish Coryphaena hippurus Linnaeus, 1758 collected from the Central Mediterranean in the period 2004-2010 by the traditional Maltese fish aggregating devices (FAD) and surface longline fisheries were studied. The a and b parameters of the length-weight relationship for fish 11-142 cm fork length (FL) (n = 4042) were determined as a = 0.018 and 0.022 with b = 2.85 and 2.79, for males and females respectively. The counting of annual increments from dorsal spines of >65 cm FL dolphinfish at X25 magnification (n = 47) permitting an age reading resolution in years , and the counting of daily increments from sagittal otoliths of <65 cm FL dolphinfish at X400 magnification (n = 583) permitting an age reading resolution in days, were estimated; the von Bertalanffy growth model applied to these fish gave the following parameters: L∞ = 107.8 cm FL and 120.2 cm FL, and K = 1.9 yr-1 and 1.56 yr-1, for males and females respectively. The maximum age observed was 2 years. Size at 50% maturity for fish 10-131 cm FL (n = 1376) was 58.9 cm FL and 62.5 cm FL for males and females, respectively. The sex ratio for the fish sampled from the FAD fishery (10.5-131 cm FL) was 1:1.54 (M:F) and for dolphinfish sampled from the surface longline fishery (91-130 cm FL) was 1:0.76 (M:F). Back-calculated hatch dates from age-0 dolphinfish (n = 518) suggested that spawning occurs from June to September with the highest levels in June. This study is the first to use dorsal spines to determine the age of adult dolphinfish.
Overconfident Competing Newsvendors
Authors: Li Meng , Petruzzi Nicholas C. , Zhang Jun 
Published: June 2016

Overconfidence is one of the most consistent, powerful, and widespread cognitive biases affecting decision making in situations characterized by random outcomes. In this paper, we study the effects and implications of overconfidence in a competitive newsvendor setting. In this context, overconfidence is defined as a cognitive bias in which decision makers behave as though the outcome of an uncertain event is less risky than it really is. This bias unequivocally leads to a lower expected profit for a newsvendor that does not compete on inventory availability. Nevertheless, it can be a positive force for competing newsvendors. Indeed, we find that when the product’s profit margin is high, overconfidence can lead to a first-best outcome. In a similar vein, we also show that the more biased of two competing newsvendors is not necessarily destined to a smaller expected profit than its less biased competitor. This paper was accepted by Manel Baucells, decision analysis.
Management of sports injuries of the foot and ankle
Authors: Ballal M. S. , Pearce C. J. , Calder J. D. F. 
Published: June 2016

Sporting injuries around the ankle vary from simple sprains that will resolve spontaneously within a few days to severe injuries which may never fully recover and may threaten the career of a professional athlete. Some of these injuries can be easily overlooked altogether or misdiagnosed with potentially devastating effects on future performance. In this review article, we cover some of the common and important sporting injuries involving the ankle including updates on their management and outcomes. Cite this article: Bone Joint J 2016;98-B:874–83.
Hip resurfacing for osteonecrosis
Authors: Amstutz H. C. , Le Duff M. J. 
Published: June 2016

AimsHip resurfacing arthroplasty (HRA) is an alternative to conventional total hip arthroplasty for patients with osteonecrosis (ON) of the femoral head. Our aim was to report the long-term outcome of HRA, which is not currently known.Patients and MethodsLong-term survivorship, clinical scores and radiographic results for 82 patients (99 hips) treated with HRA for ON over a period of 18 years were reviewed retrospectively. The mean age of the 67 men and 15 women at the time of surgery was 40.8 years (14 to 64). Patients were resurfaced regardless of the size of the osteonecrotic lesion.ResultsThe mean clinical follow-up was 10.8 years (2 to 18). The mean University of California, Los Angeles hip scores at the last follow-up were 9.3, 9.4, 9.2 and 6.8 for pain, walking, function and activity, respectively. A total of six hips underwent revision surgery, four for loosening of the femoral component and two for loosening of the acetabular component. Using any revision as an end point, the 15-year Kaplan-Meier survivorship was 90.3%. There were no wear-related failures. There were no femoral failures among the hips reconstructed with a cemented metaphyseal stem. A total of five hips showed narrowing of the femoral neck; all stabilised and remain asymptomatic, 21 showed signs of femoral neck impingement.ConclusionTo our knowledge, this is the first report of a series of HRA performed for ON with 15-year survivorship. Our data confirm that patients with advanced stages of ON of the femoral head are excellent candidates for HRA. Cite this article: Bone Joint J 2016;98-B:901–9.
Functional orientation of the acetabular component in ceramic-on-ceramic total hip arthroplasty and its relevance to squeaking
Authors: Pierrepont J. W. , Feyen H. , Miles B. P. , Young D. A. , Baré J. V. , Shimmin A. J. 
Published: June 2016

Aims Long-term clinical outcomes for ceramic-on-ceramic (CoC) bearings are encouraging. However, there is a risk of squeaking. Guidelines for the orientation of the acetabular component are defined from static imaging, but the position of the pelvis and thus the acetabular component during activities associated with edge-loading are likely to be very different from those measured when the patient is supine. We assessed the functional orientation of the acetabular component. Patients and Methods A total of 18 patients with reproducible squeaking in their CoC hips during deep flexion were investigated with a control group of 36 non-squeaking CoC hips. The two groups were matched for the type of implant, the orientation of the acetabular component when supine, the size of the femoral head, ligament laxity, maximum hip flexion and body mass index. Results The mean functional anteversion of the acetabular component at the point when patients initiated rising from a seated position was significantly less in the squeaking group than in the control group, 8.1° (-10.5° to 36.0°) and 21.1° (-1.9° to 38.4°) respectively (p = 0.002). Conclusion The functional orientation of the acetabular component during activities associated with posterior edge-loading are different from those measured when supine due to patient-specific pelvic kinematics. Individuals with a large anterior pelvic tilt during deep flexion might be more susceptible to posterior edge-loading and squeaking as a consequence of a significant decrease in the functional anteversion of the acetabular component. Cite this article: Bone Joint J 2016;98-B:910–16.
Effects of depression and inflammatory factors on chronic conditions of the wrist
Authors: Tatebe M. , Iwatsuki K. , Hirata H. , Oguchi T. , Tanaka K. , Urata S. 
Published: June 2016

Aims Chronic conditions of the wrist may be difficult to manage because pain and psychiatric conditions are correlated with abnormal function of the hand. Additionally, intra-articular inflammatory cytokines may cause pain. We aimed to validate the measurement of inflammatory cytokines in these conditions and identify features associated with symptoms. Patients and Methods The study included 38 patients (18 men, 20 women, mean age 43 years) with a chronic condition of the wrist who underwent arthroscopy. Before surgery, the Self-Rating Depression Scale (SDS), Hand20 questionnaire and a visual analogue scale (VAS) for pain were used. Cytokine and chemokine levels in the synovial fluid of the wrist were measured using enzyme-linked immunosorbent assays and correlations between the levels with pain were analysed. Gene expression profiles of the synovial membranes were assessed using quantitative polymerase chain reaction. Results Older patients had high pre-operative Hand20 scores. One-year post-operative Hand20 and VAS scores and pre-operative VAS scores correlated with SDS scores. Post-operative VAS scores negatively correlated with the expression of nerve growth factor and SDS scores positively correlated with the expression of tumour necrosis factor-alpha and negatively correlated with the expression of tumour necrosis factor-converting enzyme. Conclusion There was a positive correlation between depression and chronic conditions of the wrist. Levels of some cytokines correlate with pain and depression. Additionally, cytokines may be important in the assessment and treatment of chronic conditions of the wrist and depression. Cite this article: Bone Joint J 2016;98-B:961–8.
Wound drains in non-complex lumbar surgery
Authors: Zijlmans J. L. , Buis D. R. , Verbaan D. , Vandertop W. P. 
Published: June 2016

AimsOur aim was to perform a systematic review of the literature to assess the incidence of post-operative epidural haematomas and wound infections after one-, or two-level, non-complex, lumbar surgery for degenerative disease in patients with, or without post-operative wound drainage.Patients and MethodsStudies were identified from PubMed and EMBASE, up to and including 27 August 2015, for papers describing one- or two-level lumbar discectomy and/or laminectomy for degenerative disease in adults which reported any form of subcutaneous or subfascial drainage.ResultsEight papers describing 1333 patients were included. Clinically relevant post-operative epidural haematomas occurred in two (0.15%), and wound infections in ten (0.75%) patients. Epidural haematomas occurred in two (0.47%) patients who had wound drainage (n = 423) and in none of those without wound drainage (n = 910). Wound infections occurred in two (0.47%) patients with wound drainage and in eight (0.88%) patients without wound drainage.ConclusionThese data suggest that the routine use of a wound drain in non-complex lumbar surgery does not prevent post-operative epidural haematomas and that the absence of a drain does not lead to a significant change in the incidence of wound infection. Cite this article: Bone Joint J 2016;98-B:984–9.
Reverse total shoulder arthroplasty using a trabecular metal glenoid base plate
Authors: Theivendran K. , Varghese M. , Large R. , Bateman M. , Morgan M. , Tambe A. , Espag M. , Cresswell T. , Clark D. I. 
Published: June 2016

AimWe present the medium-term clinical results of a reverse total shoulder arthroplasty with a trabecular metal glenoid base plate.Patients and MethodsWe reviewed 125 consecutive primary reverse total shoulder arthroplasties (RTSA) implanted in 124 patients for rotator cuff arthropathy. There were 100 women and 24 men in the study group with a mean age of 76 years (58 to 89). The mean follow-up was 32 months (24 to 60). No patient was lost to follow-up.There were statistically significant improvements in the mean range of movement and Oxford Shoulder Score (p < 0.001). Kaplan-Meier survivorship at five years was 96.7% (95% confidence interval 91.5 to 98.7) with aseptic glenoid failure as the end point. Radiologically, 63 shoulders (50.4%) showed no evidence of notching, 51 (40.8%) had grade 1 notching, ten (8.0%) had grade 2 notching and one (0.8%) had grade 4 notching. Radiolucency around the glenoid base plate was found in one patient (0.8%) and around the humeral stem in five (4.0%). In all, three RTSA (2.4%) underwent revision surgery for aseptic mechanical failure of the glenoid within 11 months of surgery due to malseating of the glenosphere.ConclusionThe clinical results of this large independent single unit series are comparable to those from previous series of RTSA reported in the literature. A trabecular metal base plate is safe and effective in the medium-term. Cite this article: Bone Joint J 2016;98-B:969–75.