bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circular interpretation of regression coefficients
Authors: Cremers Jolien , Mulder Kees Tim , Klugkist Irene 
Published: September 2017

The interpretation of the effect of predictors in projected normal regression models is not straight‐forward. The main aim of this paper is to make this interpretation easier such that these models can be employed more readily by social scientific researchers. We introduce three new measures: the slope at the inflection point (bc), average slope (AS) and slope at mean (SAM) that help us assess the marginal effect of a predictor in a Bayesian projected normal regression model. TheSAMorASare preferably used in situations where the data for a specific predictor do not lie close to the inflection point of a circular regression curve. In this casebcis an unstable and extrapolated effect. In addition, we outline how the projected normal regression model allows us to distinguish between an effect on the mean and spread of a circular outcome variable. We call these types of effects location and accuracy effects, respectively. The performance of the three new measures and of the methods to distinguish between location and accuracy effects is investigated in a simulation study. We conclude that the new measures and methods to distinguish between accuracy and location effects work well in situations with a clear location effect. In situations where the location effect is not clearly distinguishable from an accuracy effect not all measures work equally well and we recommend the use of theSAM.
Antitumor effects of eribulin depend on modulation of the tumor microenvironment by vascular remodeling in mouse models
Authors: Ito Ken , Hamamichi Shusei , Abe Takanori , Akagi Tsuyoshi , Shirota Hiroshi , Kawano Satoshi , Asano Makoto , Asano Osamu , Yokoi Akira , Matsui Junji , Umeda Izumi O. , Fujii Hirofumi 
Published: September 2017

We previously reported that eribulin mesylate (eribulin), a tubulin‐binding drug (TBD), could remodel tumor vasculature (i.e. increase tumor vessels and perfusion) in human breast cancer xenograft models. However, the role of this vascular remodeling in antitumor effects is not fully understood. Here, we investigated the effects of eribulin‐induced vascular remodeling on antitumor activities in multiple human cancer xenograft models. Microvessel densities (MVD) were evaluated by immunohistochemistry (CD31 staining), and antitumor effects were examined in 10 human cancer xenograft models. Eribulin significantly increased MVD compared to the controls in six out of 10 models with a correlation between enhanced MVD levels and antitumor effects (R2 = 0.54). Because of increased MVD, we next used radiolabeled liposomes to examine whether eribulin treatment would result in increased tumoral accumulation levels of these macromolecules and, indeed, we found that eribulin, unlike vinorelbine (another TBD) enhanced them. As eribulin increased accumulation of radiolabeled liposomes, we postulated that this treatment might enhance the antitumor effect of Doxil (a liposomal anticancer agent) and facilitate recruitment of immune cells into the tumor. As expected, eribulin enhanced antitumor activity of Doxil in a post‐erlotinib treatment H1650 (PE‐H1650) xenograft model. Furthermore, infiltrating CD11b‐positive immune cells were significantly increased in multiple eribulin‐treated xenografted tumors, and natural killer (NK) cell depletion reduced the antitumor effects of eribulin. These findings suggest a contribution of the immune cells for antitumor activities of eribulin. Taken together, our results suggest that vascular remodeling induced by eribulin acts as a microenvironment modulator and, consequently, this alteration enhanced the antitumor effects of eribulin.
Critical Dogmatics as Paradigm
Authors: Hinlicky Paul R. 
Published: September 2017

AbstractTheology as “critical dogmatics” points to a way forward between naturalism and constructivism in thought “after modernity.” It urges neither pre‐critical dogmatics nor modern systematizing, but a proposal for a pragmatic and hermeneutical theology making a single claim to truth about God as the One determined to redeem and fulfill the creation through the missions of God's Son and Spirit. This article clarifies the difference between Rudolph Bultmann's program of demythologization, and more generally, dialectical theology's antinomy of “the word of God and the word of humans,” and the sense of “deliteralization” in the strong trinitarian personalism of critical dogmatics.
Lutheran Secularism as a Challenge for Constructive Theology: A Swedish Perspective, a Foucauldian Proposal
Authors: Martinson Mattias 
Published: September 2017

AbstractIn this article the Swedish Lutheran heritage is discussed in relation to its historical connections with secularism. The question is raised whether and how constructive and liberating Lutheran theology can be developed under such conditions. In order to deal with this problem, Michel Foucault's late philosophy of truth and subjectivity is discussed. A proposition is made for a constructive theology that does not retreat from secularism but is critically involved in the secular through an emphasized confidence in God.
Lutheran Subjectivity and Costly Neighbor Love in Secular Sweden: Confronting the Refugee Crisis through Alethurgy
Authors: Thompson Deanna A. 
Published: September 2017

AbstractThis article offers a constructive Lutheran theology that challenges the hegemony of secular Sweden, particularly in light of challenges posed by the current global refugee crisis. The author uses Guillermo Hanson's creative rethinking of Lutheran subjectivity to highlight a radical embodied vision of neighbor love. Retrieving Luther's claim that Muslims and Christians worship the same God, the article concludes with proposals for alethurgic practices that wed neighbor love to acknowledgement of a common God.
Speaking of the Spirit1
Authors: Rivera Nelson 
Published: September 2017

AbstractSince Gregory Nazianzus called it the “special difficulty” in the fourth century, we should not be surprised that speaking of the Holy Spirit still challenges theologians today. In this article I attempt definitions of the Spirit's activity in the church and the world, and its role within the life of the Trinity. I look for help in Paul's Letter to the Romans, from the Christian tradition, and from Luther's teaching, inviting all to this conversation about the Spirit's identity and place in an ecumenical context.
Communicating a Protesting Protestant Heritage
Authors: Rowe Terra Schwerin 
Published: September 2017

AbstractThis article opens by wondering, as many critics did during and after World War II, why a tradition named for its protesting impetus is today often marked by complacency and quietism. In conversation with political theorist William Connolly and Rev. Dr. William Barber's activism, this article suggests that Luther's unique articulation of the communicatio idiomatum might offer a compelling and coherent model for Lutheran ethical‐political agency that can provide an alternative to—rather than reinforcing—the modern isolated subject cum homo economicus often associated with idealized images of Luther's protest before the Diet of Worms.
Making Room at the Table: Lutheran Ministry in a Religiously Plural America
Authors: Grafton David D. 
Published: September 2017

AbstractReligious pluralism is a part of the American experience. This article proposes that Christianity in the United States is not under attack, as some claim, but that such religiosity has been a part of the American experience from the very beginning. Such diversity is now more public and acceptable. This reality requires clergy and lay leaders to develop skills to help their congregations navigate their ongoing multi‐faith relationships within families, at work, school, and within civic organizations. The article argues that Christian faithfulness is not a matter of changing what we believe in response to religious pluralism, but how we articulate our beliefs in such a context. Finally, the author proposes several practical guidelines for developing such pastoral skills through the use of Luther's Catechisms.
Oviposition behaviour of Tamarixia radiata: effects of host density and exposure time
Authors: CHEN XULIN , WONG SAMUEL W. K. , STANSLY PHILIP A. 
Published: September 2017

1. The number of hosts attacked as a function of host density is considered to be an important characteristic of parasitoid behaviour and is used to estimate key parameters such as handling time and ‘instantaneous rate of discovery’. However, little has been done to validate functional response models by direct observation of parasitoid oviposition behaviour.2. Tamarixia radiata is the most promising parasitoid for biological control attacking Diaphorina citri. Mass rearing and augmentative release seen as a potential strategy for suppression of D. citri has been documented in abandoned citrus, residential areas, and organic groves. Nevertheless, parasitism rates in culture and in the field are only moderate, leading to questions about oviposition behaviour in response to host density.3. Behaviours of gravid T. radiata females presented with susceptible host instars were categorised and documented by direct observation for 30 min and by camera recordings made over 12 h. Frequency of searching and antennating increased with host density during the 30 min. Probing rejection rates and search duration increased significantly with host density over 12 h. These factors resulted in significantly lower fecundity than expected, possibly due to host mark‐mediated deterrence within the small searching area. Females took approximately 3.6–4.2 min to probe and parasitise a host regardless of host density and exposure duration. These results were markedly different from the 52.2 min estimated from the functional response equation.4. Further experiments are required to assess the range and persistence of the putative host‐marking pheromone, and to better understand the relationship between functional response parameters and actual behaviour.
Direct fitness benefits explain mate preference, but not choice, for similarity in heterozygosity levels
Authors: Zandberg Lies , Gort Gerrit , van Oers Kees , Hinde Camilla A. 
Published: September 2017

AbstractUnder sexual selection, mate preferences can evolve for traits advertising fitness benefits. Observed mating patterns (mate choice) are often assumed to represent preference, even though they result from the interaction between preference, sampling strategy and environmental factors. Correlating fitness with mate choice instead of preference will therefore lead to confounded conclusions about the role of preference in sexual selection. Here we show that direct fitness benefits underlie mate preferences for genetic characteristics in a unique experiment on wild great tits. In repeated mate preference tests, both sexes preferred mates that had similar heterozygosity levels to themselves, and not those with which they would optimise offspring heterozygosity. In a subsequent field experiment where we cross fostered offspring, foster parents with more similar heterozygosity levels had higher reproductive success, despite the absence of assortative mating patterns. These results support the idea that selection for preference persists despite constraints on mate choice.
Effectiveness of the ‘Hold me Tight’ Relationship Enhancement Program in a Self‐referred and a Clinician‐referred Sample: An Emotionally Focused Couples Therapy‐Based Approach
Authors: Conradi Henk Jan , Dingemanse Pieter , Noordhof Arjen , Finkenauer Catrin , Kamphuis Jan H. 
Published: September 2017

While evidence‐based couple therapies are available, only a minority of troubled couples seek help and they often do this too late. To reach more couples earlier, the couple relationship education (CRE) group program “Hold me Tight” (HmT) based on Emotionally Focused Couples Therapy (EFCT) was developed. This study is the first to examine the effectiveness of HmT. Using a three‐wave (waiting period, treatment, and follow‐up) within‐subject design, HmT was delivered to 79 self‐referred couples and 50 clinician‐referred couples. We applied a comprehensive outcome measure battery. Our main findings were that (1) self‐referred couples significantly improved during HmT on all measures, that is relationship satisfaction, security of partner‐bond, forgiveness, daily coordination, maintenance behavior, and psychological complaints, with a moderate‐to‐large mean effect size (d = .63), which was maintained (d = .57) during the 3.5 month follow‐up; (2) in clinician‐referred couples, who were vulnerable in terms of insecure attachment status and psychopathology, the improvement during HmT was moderate (d = .42), but this was reduced during the 3.5‐month follow‐up to a small effect (d = .22); (3) emotional functioning (typical HmT target) as well as behavioral functioning (typical Behavioral Couples Therapy‐based CRE target) improved during HmT; and (4) individual psychological complaints, although not specifically targeted, were reduced during HmT. These findings suggest that HmT is a promising intervention for enhancement of relationship functioning. Clinical implications are discussed.
Subtle changes in the active site architecture untangled overlapping substrate ranges and mechanistic differences of two reductive dehalogenases
Authors: Kunze Cindy , Diekert Gabriele , Schubert Torsten 
Published: September 2017

Reductive dehalogenases (RDases) of organohalide‐respiring bacteria are cobamide‐containing iron–sulfur proteins that catalyze different reductive dehalogenation reactions. Here, we report a functional analysis of two recombinant RDases, the tetrachloroethene (PCE) reductive dehalogenase (PceA) of Desulfitobacterium hafniense Y51 and the 1,2‐dichloroethane (1,2‐DCA) reductive dehalogenase (DcaA) of Desulfitobacterium dichloroeliminans DCA1. Both enzymes share 88% protein sequence identity, but appeared to have divergent mechanisms. In this study, the heterologously produced DcaA converted 1,2‐DCA and 1,1,2‐trichloroethane (1,1,2‐TCA) via dihaloelimination to ethene and vinyl chloride, respectively. In addition, halogen substitution at PCE, trichloroethene (TCE) and tribromoethene (TBE) was observed, but only at low rates. In contrast, recombinant PceA exclusively converted halogenated ethenes and showed no dihaloelimination activity. In silico structural analysis of both RDases revealed similar architectures of their active site cavities. Exchange of the highly conserved Tyr298 to Phe led to a complete loss of the PCE, TCE and TBE conversion by both RDases, strengthening the assumption that Tyr298 functions as proton donor in the course of halogen substitution. The exchange did not affect the ability of DcaA to convert 1,2‐DCA and 1,1,2‐TCA. This result makes the involvement of a proton transfer in the dihaloelimination reaction unlikely and allows for a clear differentiation between two mechanisms working in DcaA and PceA. The analysis of the role of the active site structure for RDase function was extended to the mutations W118F that had a negative effect on DcaA function and W432F or T294V that caused alterations in the substrate specificity of the enzyme.EnzymesTetrachloroethene reductive dehalogenase (EC 1.21.99.5), DCA ‐RDase.
Climate change alters stability and species potential interactions in a large marine ecosystem
Authors: Griffith Gary P. , Strutton Peter G. , Semmens Jayson M. 
Published: September 2017

AbstractWe have little empirical evidence of how large‐scale overlaps between large numbers of marine species may have altered in response to human impacts. Here, we synthesized all available distribution data (>1 million records) since 1992 for 61 species of the East Australian marine ecosystem, a global hot spot of ocean warming and continuing fisheries exploitation. Using a novel approach, we constructed networks of the annual changes in geographical overlaps between species. Using indices of changes in species overlap, we quantified changes in the ecosystem stability, species robustness, species sensitivity and structural keystone species. We then compared the species overlap indices with environmental and fisheries data to identify potential factors leading to the changes in distributional overlaps between species. We found that the structure of the ecosystem has changed with a decrease in asymmetrical geographical overlaps between species. This suggests that the ecosystem has become less stable and potentially more susceptible to environmental perturbations. Most species have shown a decrease in overlaps with other species. The greatest decrease in species overlap robustness and sensitivity to the loss of other species has occurred in the pelagic community. Some demersal species have become more robust and less sensitive. Pelagic structural keystone species, predominately the tunas and billfish, have been replaced by demersal fish species. The changes in species overlap were strongly correlated with regional oceanographic changes, in particular increasing ocean warming and the southward transport of warmer and saltier water with the East Australian Current, but less correlated with fisheries catch. Our study illustrates how large‐scale multispecies distribution changes can help identify structural changes in marine ecosystems associated with climate change.
Effect of ensiling corn stover with legume herbages in different proportions on fermentation characteristics, nutritive quality and in vitro digestibility on the Tibetan Plateau
Authors: Wang Siran , Yuan Xianjun , Dong Zhihao , Li Junfeng , Shao Tao 
Published: September 2017

AbstractIn order to evaluate the nutritional value and digestibility of corn (Zea mays L.) stover silage mixed with legume herbages in Tibet, corn stover was ensiled with four levels (0, 10, 20 and 30% of fresh weight) of common vetch (Vicia sativa L.) and alfalfa (Medicago sativa L.), respectively. The silos were opened after 45 days of ensiling, and the fermentation characteristics, nutritive quality and in vitro digestibility of the mixed silages were analyzed. The results showed that the inclusion of legumes could somewhat improve the corn stover silage quality, as indicated by significantly (P < 0.05) higher lactic acid and crude protein contents and ratios of lactic acid/acetic acid, and significantly (P < 0.05) lower amylase‐treated neutral detergent fiber, acid detergent fiber and hemicellulose contents, while the corn stover silage containing 10% common vetch performed best, as indicated by significantly (P < 0.05) higher in vitro dry matter and neutral detergent fiber digestibility. These results suggest that mixing legumes to corn stover before ensiling appears to be a feasible strategy to improve the nutritive quality of mixed silage.
Infrastructural governance and social history: roads in colonial and postcolonial India
Authors: Sinha Nitin 
Published: September 2017

AbstractThis essay combines historiographical overview and reflections on possible future themes to argue that roads are not just physical pathways but are part of social, economic, and political discourses of the time. The relationship between infrastructure and governance and the possibility of writing the social have been shown here by creating a dialogue between the past and present, thus bringing colonial and postcolonial times of South Asia into one analytical field.
Politics and diplomacy in the Latin East: The principality of Antioch in historiographical perspective
Authors: Buck Andrew D. 
Published: September 2017

AbstractOne of four “crusader states” formed following the First Crusade, the principality of Antioch was built on turbulent foundations. Its Latin settlers faced not only various Islamic powers, they also had to contend with the Byzantine Empire, whose rulers claimed the city and its environs for themselves; the Armenian Christians of Cilicia; and the rival machinations of the other Frankish states, particularly the kingdom of Jerusalem. The instability this facilitated, and the power of those who vied for influence with Antioch, has had a profound impact on modern historiography. Thus, the principality has been portrayed as a rigorous autocratic state, whose relationships—internal and external—were primarily shaped by outside forces. This article explores these trends, proposing that the principality of Antioch's power structures were far more dynamic than once imagined and that its ruling elites played a more proactive, delicate diplomatic game than historians have recognised.
Sugar feeding of parasitoids in an agroecosystem: effects of community composition, habitat and vegetation
Authors: Kishinevsky Miriam , Cohen Nitzan , Chiel Elad , Wajnberg Eric , Keasar Tamar 
Published: September 2017

Abstract

Sugar from nectar or from honeydew can prolong parasitoids’ lifespan, enhance their fecundity and foraging ability, and thereby increase their pest suppression efficiency. Sugar sources within crop monocultures are considered to be limiting for parasitoids. Nevertheless, only few studies have measured the sugar feeding of parasitoid assemblages in agricultural areas or in surrounding non‐crop habitats.

We used cold anthrone tests to compare the frequency of sugar feeding in parasitoid communities, inside pomegranate orchards and in adjacent natural areas, over two consecutive years. Overall, 40% of the 1610 sampled individuals belonging to 135 species scored positive for sugar.

Sugar‐feeding frequency was lower within the orchards than in the neighbouring natural areas. The proportion of sugar‐fed wasps increased with herbaceous vegetation cover, both within and outside the orchards, suggesting that herbs are a sugar‐rich habitat. Parasitoids sampled from trees and from herbs within the orchards had similar frequencies of sugar feeding, despite differences in wasp species composition.

Our results probably overestimate sugar‐feeding frequencies in the field because sugar‐fed individuals have higher longevity and hence are more likely to be sampled. We propose a simple model to approximate this over‐sampling bias and apply it to Encarsia inaron (Aphelinidae), one of the most abundant parasitoids in the samples.

We conclude that sugar availability potentially limits parasitoid fitness in this agro‐ecosystem. This may be due to the low density of plants in natural areas during the Mediterranean summer, and to herbicide applications within the orchards that further suppress non‐crop herbs.