bluuebunny/crossref_metadata_2025_split huggingface dataset:
Costimulation Endows Immunotherapeutic CD8 T Cells with IL-36 Responsiveness during Aerobic Glycolysis
Authors: Tsurutani Naomi , Mittal Payal , St. Rose Marie-Clare , Ngoi Soo Mun , Svedova Julia , Menoret Antoine , Treadway Forrest B. , Laubenbacher Reinhard , Suárez-Ramírez Jenny E. , Cauley Linda S. , Adler Adam J. , Vella Anthony T. 
Published: November 2015

Abstract
CD134- and CD137-primed CD8 T cells mount powerful effector responses upon recall, but even without recall these dual-costimulated T cells respond to signal 3 cytokines such as IL-12. We searched for alternative signal 3 receptor pathways and found the IL-1 family member IL-36R. Although IL-36 alone did not stimulate effector CD8 T cells, in combination with IL-12, or more surprisingly IL-2, it induced striking and rapid TCR-independent IFN-γ synthesis. To understand how signal 3 responses functioned in dual-costimulated T cells we showed that IL-2 induced IL-36R gene expression in a JAK/STAT-dependent manner. These data help delineate a sequential stimulation process where IL-2 conditioning must precede IL-36 for IFN-γ synthesis. Importantly, this responsive state was transient and functioned only in effector T cells capable of aerobic glycolysis. Specifically, as the effector T cells metabolized glucose and consumed O2, they also retained potential to respond through IL-36R. This suggests that T cells use innate receptor pathways such as the IL-36R/axis when programmed for aerobic glycolysis. To explore a function for IL-36R in vivo, we showed that dual costimulation therapy reduced B16 melanoma tumor growth while increasing IL-36R gene expression. In summary, cytokine therapy to eliminate tumors may target effector T cells, even outside of TCR specificity, as long as the effectors are in the correct metabolic state.
The Haube Revolt: Conflict and Disagreement in the Moravian Community of Nazareth, Pennsylvania, 1815
Authors: Peucker Paul 
Published: November 2015

ABSTRACT
In 1815 the Moravian women in Nazareth replaced their traditional Moravian bonnets and with more contemporary headgear. This article places these actions in the context of a changing Moravian Church during the early republic. The events of 1815 reveal how Moravians were becoming Americanized and how they developed different expectations regarding personal freedom versus church control. The Haube Revolt may be seen against the backdrop of a growing sense of American liberty and national pride, fed by the changing tide of the War of 1812.
You Complete Me: Posthumous Works and Secondary Agency
Authors: Bacharach Sondra , Tollefsen Deborah 
Published: November 2015

Abstract
Many works are attributed to artists after their death, even when someone else has contributed substantively to the content of the work or when the work left by the artist is deemed incomplete by any standard of completion. Call these works posthumous works. These cases give rise to several interesting and related questions about the ontology of artworks and authorship: If the works are incomplete when the first artist dies, then can someone else complete them, or do they remain forever unfinished? Are works that are altered after the artist’s death new and distinct works? If they remain forever unfinished, then what is the unfinished works’ relation to the putatively "finished" work? If, on the other hand, they can be finished and are finished by someone other than the original artist (since the original artist is dead), then to whom to do we give credit: the deceased artist, the finishing artist, or both? Recent accounts of when an artwork is complete make posthumous works impossible. In this paper, we offer an explanation of how the unfinished work of the dead can be completed and why in these cases attributing the work to the dead is justified.
Injection of Human Cord Blood Cells With Hyaluronan Improves Postinfarction Cardiac Repair in Pigs
Authors: Chang Ming-Yao , Huang Tzu-Ting , Chen Chien-Hsi , Cheng Bill , Hwang Shiaw-Min , Hsieh Patrick C.H. 
Published: November 2015

Abstract

Recent clinical trials using autologous bone marrow or peripheral blood cells to treat myocardial infarction (MI) show controversial results, although the treatment has a good safety profile. These discrepancies are likely caused by factors such as aging, systemic inflammation, and cell processing procedures, all of which might impair the regenerative capability of the cells used. Here, we tested whether injection of human cord blood mononuclear cells (CB-MNCs) combined with hyaluronan (HA) hydrogel improves cell therapy efficacy in a pig MI model. A total of 34 minipigs were divided into 5 groups: sham operation (Sham), surgically induced-MI plus injection with normal saline (MI+NS), HA only (MI+HA), CB-MNC only (MI+CB-MNC), or CB-MNC combined with HA (MI+CB-MNC/HA). Two months after the surgery, injection of MI+CB-MNC/HA showed the highest left ventricle ejection fraction (51.32% ± 0.81%) compared with MI+NS (42.87% ± 0.97%, p &lt; .001), MI+HA (44.2% ± 0.63%, p &lt; .001), and MI+CB-MNC (46.17% ± 0.39%, p &lt; .001) groups. The hemodynamics data showed that MI+CB-MNC/HA improved the systolic function (+dp/dt) and diastolic function (−dp/dt) as opposed to the other experimental groups, of which the CB-MNC alone group only modestly improved the systolic function (+dp/dt). In addition, CB-MNC alone or combined with HA injection significantly decreased the scar area and promoted angiogenesis in the infarcted region. Together, these results indicate that combined CB-MNC and HA treatment improves heart performance and may be a promising treatment for ischemic heart diseases.

Significance
This study using healthy human cord blood mononuclear cells (CB-MNCs) to treat myocardial infarction provides preclinical evidence that combined injection of hyaluronan and human CB-MNCs after myocardial infarction significantly increases cell retention in the peri-infarct area, improves cardiac performance, and prevents cardiac remodeling. Moreover, using healthy cells to replace dysfunctional autologous cells may constitute a better strategy to achieve heart repair and regeneration.
Différences de genres musicaux ou différences de pratiques ? Une voie pour renouveler les pratiques pédagogiques en musique
Authors: Schepens Eddy 
Published: November 2015

Le Cefedem Rhône-Alpes est un centre de formation supérieure des professeurs de musique. Depuis 2000, il accueille de jeunes musiciens pratiquant des genres musicaux différents au sein d’un cursus commun, en dépassant la répartition en guichets spécifiques qui le plus souvent, en France, les séparent. À l’objectif d’accueillir tous les publics au-delà des singularités de parcours et de profils sociologiques s’ajoute un enjeu artistique : la reconnaissance de la diversité ne peut se contenter d’une juxtaposition bienveillante de ces genres, elle doit permettre à chaque musicien de prendre connaissance de la musique de l’autre par les pratiques. Basée sur une pédagogie par projets et par contrats, cette formation inédite permet de substituer à la notion courante de genres musicaux celle de pratiques de musiciens, permettant pour chaque moment musical et chaque situation de formation pédagogique l’analyse des procédures utilisées, l’analyse des modes de coopération des musiciens entre eux, ainsi que l’invention de dispositifs créant des contextes musicaux et pédagogiques dédiés à de telles approches. L’objectif de cette formation est de former des futurs professeurs ayant acquis des compétences pour travailler en équipes pluridisciplinaires, capables de créer des contextes de pratiques musicales plus divers et de s’adresser à des publics plus variés.
Répertoires vocaux enseignés de la maternelle à la fin du collège, en « éducation musicale » en France
Authors: Tripier-Mondancin Odile , Maizières Frédéric 
Published: November 2015

Dès les débuts de l’enseignement de la musique, dénommé « éducation musicale » dans l’école généraliste française, le chant apparaît comme l’une des deux activités principales. Même si aucun répertoire n’a jamais été véritablement imposé, des orientations institutionnelles successives ont pu mettre l’accent sur des idéologies politiques, morales, ou encore, sur la chanson en tant qu’outil au service de la langue (Alten 1995). Mais aujourd’hui, alors que l’on parle de culture commune au sein de l’école, qu’en est-il des répertoires enseignés en France ? Quel est l’impact des pratiques musicales sociales de référence et de la culture des enseignants sur le répertoire qu’ils choisissent ? Deux enquêtes nationales inter-académiques à visée descriptive/compréhensive adressées simultanément aux enseignants du premier degré (école primaire ; n=935) et du second degré (collège ; n=104) permettent de mettre en évidence, certaines caractéristiques du répertoire chanté dans les classes de la maternelle à la fin du collège. On relève notamment l’utilisation assez constante de la chanson française des années 1945-1968, soit celle des auteurs-compositeurs-interprètes de la rive gauche parisienne. Les résultats montrent également des liens entre l’école primaire et le collège : la récurrence de certains auteurs tend à montrer une certaine continuité de l’école primaire au collège. Des différences assez nettes, apparaissent notamment au niveau de certaines catégories musicales (chanson enfantine à l’école primaire, répertoire jazz et savant au collège). Les critères de choix (le texte à l’école primaire, la question de la faisabilité vocale dans les deux cas et les notions musicales au collège) témoignent à la fois d’enjeux différents d’un cycle à l’autre, mais aussi de la spécificité des enseignants qui ont en charge cet enseignement (enseignant généraliste à l’école primaire et enseignant spécialisé au collège).
La construction de l’identité professionnelle à l’épreuve de la formation : le cas des étudiants belges se formant à enseigner l’éducation musicale
Authors: Deltand Muriel 
Published: November 2015

Envisageant les stages d’enseignement comme un moment charnière dans la construction de l’identité professionnelle, notre recherche a pour objectif d’interroger le vécu d’étudiants en situation d’enseignement musical n’ayant pas d’expériences artistiques avant l’entrée en formation. Comment ces étudiants, se destinant à devenir des instituteurs du primaire vivent-ils cette expérience, se positionnent-ils envers la didactique de l’éducation musicale et structurent-ils leur rapport à cette discipline au regard de leur projet identitaire ? Trois étudiantes issues d’une étude réalisée de 2009 à 2012 et composée de quinze sujets témoignent de leur projet, de l’expérience didactique et de l’accompagnement reçu des maîtres de stage en Belgique. Par ces trajectoires, l’étude fait apparaître quatre thématiques importantes pour le domaine de la formation. Il s’agit du projet identitaire comme fil conducteur du rapport à l’expérience, du rôle des accompagnants, de la reconnaissance de l’autrui significatif et enfin de la relativisation du manque d’antécédents d’expérience en éducation musicale avant l’entrée en formation. Ces résultats permettent d’alimenter la réflexion relative aux liens entre l’expérience en situation, l’éducation musicale et l’identité professionnelle en formation.
Efeito da época de aplicação de herbicidas sulfonilureias no controle de azevém anual na cultura do trigo
Authors: Santos Jony Cley dos , Mendes Marcelo Cruz , Rosário Jerônimo Gadens do , Camargo Junior Osnil Alves , Maciel Cleber Daniel de Goes 
Published: November 2015

A adoção de práticas de manejo de plantas daninhas constitui em uma das principais ferramentas que podem contribuir para o aumento da produtividade de grãos nas lavouras de trigo. O presente estudo teve como objetivo avaliar a eficiência dos herbicidas do grupo químico das sulfonilureias, isolados e em associação, em diferentes épocas da aplicação sobre a produtividade de cultivares comerciais de trigo, e no controle do azevém anual (Lolium multiflorum L.). O delineamento foi o de blocos casualisados, com 5 repetições. Os tratamentos foram arranjados em esquema fatorial 4 x 2 x 2, compostos pela aplicação de metsulfuron-methyl e iodosulfuron- methyl, isolados e em associação e testemunha, utilizando duas cultivares comerciais de trigo (Quartzo e BRS Tangará) em duas épocas de aplicação 21 e 30 dias após a aplicação. Foram avaliados a fitointoxicação das cultivares, o nível de controle do azevém anual e o rendimento das características agronômicas da cultura do trigo. Para o controle do azevém anual constatou-se que há diferença quando utilizado os herbicidas sulfoniluréias, sendo o iodosulfuron-methyl em uso isolado e em associação com o metsulfuron-methyl eficiente no controle. A aplicação de iodosulfuron-methyl (5,0 g i.a. ha-1) e metsulfuron-methyl (2,4 g i.a. ha-1) + iodosulfuron-methyl (5,0 g i.a. ha-1) aos 30 dias após a semeadura resultou na maior produtividade de grãos de trigo.
Nitrogen cycling in the secondary nitrite maximum of the eastern tropical North Pacific off Costa Rica
Authors: Buchwald Carolyn , Santoro Alyson E. , Stanley Rachel H. R. , Casciotti Karen L. 
Published: November 2015

AbstractNitrite is a central intermediate in the marine nitrogen cycle and represents a critical juncture where nitrogen can be reduced to the less bioavailable N2 gas or oxidized to nitrate and retained in a more bioavailable form. We present an analysis of rates of microbial nitrogen transformations in the oxygen deficient zone (ODZ) within the eastern tropical North Pacific Ocean (ETNP). We determined rates using a novel one‐dimensional model using the distribution of nitrite and nitrate concentrations, along with their natural abundance nitrogen (N) and oxygen (O) isotope profiles. We predict rate profiles for nitrate reduction, nitrite reduction, and nitrite oxidation throughout the ODZ, as well as the contributions of anammox to nitrite reduction and nitrite oxidation. Nitrate reduction occurs at a maximum rate of 25 nM d−1 at the top of the ODZ, at the same depth as the maximum rate of nitrite reduction, 15 nM d−1. Nitrite oxidation occurs at maximum rates of 10 nM d−1 above the secondary nitrite maximum, but also in the secondary nitrite maximum, within the ODZ. Anammox contributes to nitrite oxidation within the ODZ but cannot account for all of it. Nitrite oxidation within the ODZ that is not through anammox is also supported by microbial gene abundance profiles. Our results suggest the presence of nitrite oxidation within the ETNP ODZ, with implications for the distribution and physiology of marine nitrite‐oxidizing bacteria, and for total nitrogen loss in the largest marine ODZ.
Ion upflow dependence on ionospheric density and solar photoionization
Authors: Cohen I. J. , Lessard M. R. , Varney R. H. , Oksavik K. , Zettergren M. , Lynch K. A. 
Published: November 2015

AbstractMotivated by rocket observations showing a variety of different ionospheric responses to precipitation, this paper explores the influence of the background ionospheric density on upflow resulting from auroral precipitation. Simulations of upflow driven by auroral precipitation were conducted using a version of the Varney et al. (2014) model driven by precipitation characterized by observations made during the 2012 Magnetosphere‐Ionosphere Coupling in the Alfvén resonator rocket mission and using a variety of different initial electron density profiles. The simulation results show that increased initial density before the onset of precipitation leads to smaller electron temperature increases, longer ionospheric heating timescales, weaker ambipolar electric fields, lower upflow speeds, and longer upflow timescales but larger upflow fluxes. The upflow flux can increase even when the ambipolar electric field strength decreases due to the larger number of ions that are accelerated. Long‐term observations from the European Incoherent Scatter (EISCAT) Svalbard radar taken during the International Polar Year support the effects seen in the simulations. This correlation between ionospheric density and ion upflows emphasizes the important role of photoionization from solar ultraviolet radiation, which the EISCAT observations show can increase ionospheric density by as much as an order of magnitude during the summer months.
Insights from heterogeneous structures of the 1999 Mw 7.6 Chi‐Chi earthquake thrust termination in and near Chushan excavation site, Central Taiwan
Authors: Huang Wen‐Jeng , Chen Wen‐Shan , Lee Yuan‐Hsi , Yang Chih‐Cheng , Lin Ming‐Lang , Chiang Cheng‐Shing , Lee Jian‐Cheng , Lu Shih‐Ting 
Published: November 2015

AbstractWe describe and analyze the surface and subsurface deformation of the 1999 Chi‐Chi earthquake thrust termination of the Chelungpu fault in and near the Chushan excavation site, central Taiwan. In order to minimize damage to engineering structures within a deformation zone and formulate regulations for earthquake fault zones and fault setbacks, one needs to know the characteristics of the deformation zone and the connection between surface and subsurface deformation. The surface deformation zone of high strain induced by the earthquake faulting ranges from 15 to 70 m in width, and characterized by a 0.5 to 2 m high escarpment is much wider in the hanging wall. Exposures in the trench, 40 m long and 10 m deep, excavated across the earthquake ground rupture, show on the one hand the heterogeneous structure of a steep, monocline‐like fold. On the other hand, strikingly different surface deformation profiles on either side of the 14 m wide trench, i.e., semiparabola‐like and monoclinal, do not reflect in any obvious way the subsurface structure. The analysis of our detailed mapping results along with well logs suggests that the significant width variation of the surface deformation zone is attributed to secondary faults branching from the dominant fault at several tens of meters depth. The surface profile of the escarpment is controlled by the depth of the relevant fault tip, and the subsurface heterogeneous structure formed during at least four earthquakes.
Joint modeling of lithosphere and mantle dynamics: Evaluation of constraints from global tomography models
Authors: Wang Xinguo , Holt William E. , Ghosh Attreyee 
Published: November 2015

AbstractWith the advances in technology, seismological theory, and data acquisition, a number of high‐resolution seismic tomography models have been published. However, discrepancies between tomography models often arise from different theoretical treatments of seismic wave propagation, different inversion strategies, and different data sets. Using a fixed velocity‐to‐density scaling and a fixed radial viscosity profile, we compute global mantle flow models associated with the different tomography models and test the impact of these for explaining surface geophysical observations (geoid, dynamic topography, stress, and strain rates). We use the joint modeling of lithosphere and mantle dynamics approach of Ghosh and Holt (2012) to compute the full lithosphere stresses, except that we use HC for the mantle circulation model, which accounts for the primary flow‐coupling features associated with density‐driven mantle flow. Our results show that the seismic tomography models of S40RTS and SAW642AN provide a better match with surface observables on a global scale than other models tested. Both of these tomography models have important similarities, including upwellings located in Pacific, Eastern Africa, Iceland, and mid‐ocean ridges in the Atlantic and Indian Ocean and downwelling flows mainly located beneath the Andes, the Middle East, and central and Southeast Asia.
Distinguishing between Traumatic and Non‐Traumatic Memory: A Commentary on Reminiscing and Child Maltreatment
Authors: Valentino Kristin , McDonnell Christina G. 
Published: November 2015

SummarySalmon and Reese review literature on parent–child conversations about children's negative experiences and consider how impoverished parent–child reminiscing about child sexual abuse may affect children's memory for that trauma. To extend the application of developmental psychopathology theory to the study of reminiscing and memory, the present commentary had three overarching goals. First, evidence supporting relatively accurate retention of memories for trauma in contrast to impairments in non‐traumatic autobiographical memory among maltreated children is reviewed. Second, the influence of mother–child reminiscing about everyday emotional experiences on maltreated children's autobiographical memory and socio‐emotional functioning is considered. Third, translational implications are discussed.Copyright © 2015 John Wiley & Sons, Ltd.
Conversations and Memory Processes: A Commentary
Authors: Bauer Patricia J. 
Published: November 2015

SummaryThis commentary on Salmon and Reese lauds the efforts of the authors to explain the significance of parent–child conversations about negative events and experiences for children's subsequent memory for them. Salmon and Reese place their review in the context of theories of social–cultural development and attachment relationships, perspectives essential to understanding the development of skilled remembering. This commentary elaborates on Salmon and Reese's analysis by focusing on the basic processes involved in memory formation and later retrieval, with special emphasis on those that contribute to forgetting. The analysis further elucidates the myriad ways that parent–child conversations influence children's memory. Copyright © 2015 John Wiley & Sons, Ltd.
The Limitations of Our Knowledge About Social Influences on Memories of Sexual Abuse over the Long Term
Authors: Koppel Jonathan , Berntsen Dorthe 
Published: November 2015

SummaryFagin, Cyr, and Hirst provide an informed and insightful application of the social memory literature to the important question of how memories of sexual abuse may be re‐shaped, both over the short term and long term, by communication with others, as well as with oneself. In the following commentary, we outline several respects in which we believe that the application of this literature to memories of sexual abuse, particularly over the long term, is still open to debate. In particular, we focus on induced forgetting and social contagion for such memories, as well as the application of the social memory literature to intrusive involuntary memories of trauma. Where applicable, we offer suggestions for future research that may contribute towards addressing the limitations of the existing literature. Copyright © 2015 John Wiley & Sons, Ltd.
Telling and Remembering: Complexities in Long‐term Effects of Listeners on Autobiographical Memory
Authors: Pasupathi Monisha , Oldroyd Kristina 
Published: November 2015

SummaryThe fact that people talk about most of their emotional experiences with others is well established, as are the influences of listeners on the nature of such talk. Established effects of variability in that talk—such as those due to the listener's attentiveness—could also influence later memory, but the evidence directly testing such influences is relatively sparse. We report the results of a study in which participants (n = 64, 30 men) initially narrated a positive or negative experience to a same‐sex friend. The friend was randomly assigned to be either a responsive or a distracted listener, which resulted in changes to the conversational narration that are reported elsewhere. In a second session, approximately 1 month later, participants were asked to recall the same experience. In this study, we examined whether event valence and listener condition influenced the retention of information from the session 1 narrative at the follow‐up session, as well as the consistency of the session 2 narratives with the session 1 narrative. Prior findings linking more attentive listening to higher retention and consistency were partially replicated in the present study but were moderated by gender (retention) and event valence (consistency). Broader implications of these findings are discussed.