bluuebunny/crossref_metadata_2025_split huggingface dataset:
Principales complicaciones asociadas a la administración de quimioterapia intraperitoneal y endovenosa en pacientes con cáncer de ovario
Authors: Palmés Ferrera Mercedes , Andersson Vila Cassandra Ixena , Barrera Reyes Maria del Carmen , García Gigán Maria del Carmen , Graells Piqué Maria Alba , Gómez Rodríguez Esther 
Published: July 2017

Antecedentes: El cáncer de ovario causa más muertes que cualquier otro tipo de cáncer ginecológico. La mayoría de casos se diagnostican en una etapa avanzada de la enfermedad y el tratamiento de elección es generalmente la terapia combinada de quimioterapia intraperitoneal (IP) y endovenosa (EV). A pesar de que esta opción farmacológica ha demostrado alargar la supervivencia, se han reportado múltiples efectos adversos asociados a dicho tratamiento. <br />Objetivo: Identificar los efectos adversos y las complicaciones derivadas del tratamiento con quimioterapia IP+EV en pacientes con carcinoma de ovario avanzado a partir de estadio IIIC, durante el periodo 2007-2015.<br />Metodología: Se realizó un estudio descriptivo, longitudinal y retrospectivo. Un grupo de 17 mujeres diagnosticadas con cáncer de ovario a partir de estadio III fueron tratadas con quimioterapia IP+EV en el Hospital Clínic de Barcelona durante el periodo 2007-2015.<br />Resultados: De las 17 pacientes que recibieron tratamiento con quimioterapia IP+EV, sólo 5 (29,41%) finalizaron los 6 ciclos de tratamiento. De forma notable, 12 (70,58%) pacientes no completaron el tratamiento debido a una serie de complicaciones, que fueron frecuentemente asociadas al reservorio IP y a trastornos psicológicos. Los principales efectos adversos reportados fueron astenia, neurotoxicidad y dolor abdominal. <br />Conclusiones: La mayoría de pacientes interrumpieron la terapia debido a complicaciones relacionadas con el reservorio IP y trastornos psicológicos. Creemos que la enfermera juega un papel importante, no sólo en el manejo de los aspectos técnicos de la terapia, sino también en el soporte emocional a dichas pacientes durante esta etapa.<br /><br />
Les modes de sélection des candidats affectent-ils la représentation parlementaire des minorités d’origine étrangère ? Une analyse des élections législatives allemandes de 2013
Authors: Deiss-Helbig Elisa 
Published: July 2017

À la suite des différentes vagues d’immigration des dernières décennies, l’Allemagne, comme la plupart des sociétés contemporaines, est fortement caractérisée par sa diversité ethnique. Pourtant, on ne trouve que très rarement des députés issus de l’immigration au sein du Bundestag. Cet article analyse un aspect de plus en plus évident au vu de la littérature scientifique, mais qui reste peu traité pour l’instant : la relation entre les différents modes de sélection des candidats et la représentation parlementaire des minorités d’origine étrangère. L’analyse empirique de l’impact des procédures d’investiture des partis politiques allemands sur la diversité ethnique des candidats parlementaires est réalisée à partir des statuts des différents partis ainsi que des procès-verbaux des congrès d’investiture des partis. Les résultats de notre analyse exploratoire indiquent tout d’abord qu’en raison des prescriptions légales, les modes de sélection des différents partis politiques allemands présentent une grande homogénéité. Pourtant, nous pouvons également montrer qu’il existe des divergences inter-partisanes (entre, d’un côté, les deux grands partis et, de l’autre, les trois petits) ainsi qu’intra-partisanes (entre les différents Länder allemands). En ce qui concerne la sélection des candidats d’origine étrangère, le positionnement idéologique du parti semble jouer un grand rôle : ce sont avant tout les partis de gauche qui sélectionnent les candidats issus des minorités ethniques. Néanmoins, au-delà de cet impact du positionnement idéologique des partis, nous pouvons également établir qu’au sein du groupe des partis de gauche, des modes de sélection plus ouverts semblent pouvoir contribuer à une plus grande accessibilité aux listes par des aspirants-candidats issus de l’immigration.
Increasing frequency and duration of Arctic winter warming events
Authors: Graham Robert M. , Cohen Lana , Petty Alek A. , Boisvert Linette N. , Rinke Annette , Hudson Stephen R. , Nicolaus Marcel , Granskog Mats A. 
Published: July 2017

AbstractNear‐surface air temperatures close to 0°C were observed in situ over sea ice in the central Arctic during the last three winter seasons. Here we use in situ winter (December–March) temperature observations, such as those from Soviet North Pole drifting stations and ocean buoys, to determine how common Arctic winter warming events are. Observations of winter warming events exist over most of the Arctic Basin. Temperatures exceeding −5°C were observed during >30% of winters from 1954 to 2010 by North Pole drifting stations or ocean buoys. Using the ERA‐Interim record (1979–2016), we show that the North Pole (NP) region typically experiences 10 warming events (T2m > −10°C) per winter, compared with only five in the Pacific Central Arctic (PCA). There is a positive trend in the overall duration of winter warming events for both the NP region (4.25 days/decade) and PCA (1.16 days/decade), due to an increased number of events of longer duration.
Metal Oxides as Efficient Charge Transporters in Perovskite Solar Cells
Authors: Haque Md Azimul , Sheikh Arif D. , Guan Xinwei , Wu Tom 
Published: July 2017

AbstractOver the past few years, hybrid halide perovskites have emerged as a highly promising class of materials for photovoltaic technology, and the power conversion efficiency of perovskite solar cells (PSCs) has accelerated at an unprecedented pace, reaching a record value of over 22%. In the context of PSC research, wide‐bandgap semiconducting metal oxides have been extensively studied because of their exceptional performance for injection and extraction of photo‐generated carriers. In this comprehensive review, we focus on the synthesis and applications of metal oxides as electron and hole transporters in efficient PSCs with both mesoporous and planar architectures. Metal oxides and their doped variants with proper energy band alignment with halide perovskites, in the form of nanostructured layers and compact thin films, can not only assist with charge transport but also improve the stability of PSCs under ambient conditions. Strategies for the implementation of metal oxides with tailored compositions and structures, and for the engineering of their interfaces with perovskites will be critical for the future development and commercialization of PSCs.
Brief Report: Clinical and Molecular Phenotypes of Low‐Penetrance Variants of NLRP3: Diagnostic and Therapeutic Challenges
Authors: Kuemmerle‐Deschner J. B. , Verma D. , Endres T. , Broderick L. , de Jesus A. A. , Hofer F. , Blank N. , Krause K. , Rietschel C. , Horneff G. , Aksentijevich I. , Lohse P. , Goldbach‐Mansky R. , Hoffman H. M. , Benseler S. M. 
Published: July 2017

ObjectiveCryopyrin‐associated periodic syndromes (CAPS) result from gain‐of‐function mutations in the NLRP3 gene, which causes excessive release of interleukin‐1β (IL‐1β) and systemic inflammation. While pathogenetic NLRP3 variant phenotypes are well‐characterized, low‐penetrance NLRP3 variants represent a significant clinical challenge. The aims of this study were to determine the clinical phenotype, the in vitro biologic phenotype, and the effect of anti–IL‐1 treatment in patients with low‐penetrance NLRP3 variants.MethodsA multicenter study of consecutive symptomatic patients with low‐penetrance NLRP3 variants recruited from 7 centers between May 2012 and May 2013 was performed. The observed findings were transferred into a study database, from which they were extracted for analysis. Controls were patients with a known pathogenetic NLRP3 variant. Clinical presentation and CAPS markers of inflammation were captured. Functional assays of inflammasome activation, including caspase 1 activity, NF‐κB release, cell death, and IL‐1β release, were performed. Treatment effects of IL‐1 were determined. Comparisons between low‐penetrance and pathogenetic NLRP3 variants were performed.ResultsThe study included 45 patients, 21 of which were female (47%); 26 of the patients (58%) were children. NLRP3 low‐penetrance variants identified in the patients were Q703K (n = 19), R488K (n = 6), and V198M (n = 20). In the controls, 28 had pathogenetic NLRP3 variants. Patients with low‐penetrance NLRP3 variants had significantly more fever (76%) and gastrointestinal symptoms (73%); eye disease, hearing loss, and renal involvement were less common. Functional inflammasome testing identified an intermediate phenotype in low‐penetrance NLRP3 variants as compared to wild‐type and pathogenetic NLRP3 variants. All treated patients responded to IL‐1 inhibition, with complete response documented in 50% of patients.ConclusionPatients with low‐penetrance NLRP3 variants display a distinct clinical phenotype and an intermediate biologic phenotype, including IL‐1β and non–IL‐1β–mediated inflammatory pathway activation.
Oxygen‐Deficient Three‐Dimensional Porous Co3O4 Nanowires as an Electrode Material for Water Oxidation and Energy Storage
Authors: Fan Xiaolei , Balogun Muhammad‐Sadeeq , Huang Yongchao , Tong Yexiang 
Published: July 2017

AbstractEnergy storage and conversion have become two of the most promising aspects of study, and both fields share a common approach in the search for new and advanced materials to store/convert energy and catalyze electrochemical reactions. Owing to their environmental friendliness, transition‐metal oxides have been widely applied as electrode materials for energy systems. However, the application of these metal oxides, in one way or another, tends to suffer from several disadvantages, which urge many researchers to concentrate on improving the performance of the metal oxides so as to meet the demand of different applications. Herein, oxygen vacancies were introduced into 3D Co3O4 nanowires and utilized as suitable electrodes for water oxidation and lithium‐ion batteries.
Particle Generation Using High‐Pressure Atomization
Authors: Stein Oliver , Bröckel Ulrich , Riebel Ulrich , Hansen Herbert 
Published: July 2017

AbstractFeinstpartikel in der Größenordnung weniger Mikrometer finden Anwendung in den unterschiedlichsten Industriezweigen. Als Alternative zu bekannten Herstellungsverfahren wird ein lösungsmittelfreies Hochdrucksprühverfahren zur Feststoffmikronisierung vorgestellt. Die Basis bildet ein gepulst arbeitender Diesel‐Injektor eines handelsüblichen Common‐Rail‐Systems aus dem Automotive‐Bereich. Die Modellsubstanzen werden als Schmelze oder konzentrierte Lösungen vorgelegt. Die mikroskaligen Feststoffpartikel resultieren aus dem erstarrten bzw. getrockneten Produktspray und weisen eine enge Partikelgrößenverteilung auf.
Optimization and standardization of fluorescent cell barcoding for multiplexed flow cytometric phenotyping
Authors: Giudice Valentina , Feng Xingmin , Kajigaya Sachiko , Young Neal S. , Biancotto Angélique 
Published: July 2017

AbstractFluorescent cell barcoding (FCB) is a cell‐based multiplexing technique for high‐throughput flow cytometry. Barcoded samples can be stained and acquired collectively, minimizing staining variability and antibody consumption, and decreasing required sample volumes. Combined with functional measurements, FCB can be used for drug screening, signaling profiling, and cytokine detection, but technical issues are present. We optimized the FCB technique for routine utilization using DyLight 350, DyLight 800, Pacific Orange, and CBD500 for barcoding six, nine, or 36 human peripheral blood specimens. Working concentrations of FCB dyes ranging from 0 to 500 μg/ml were tested, and viability dye staining was optimized to increase robustness of data. A five‐color staining with surface markers for Vβ usage analysis in CD4+ and CD8+ T cells was achieved in combination with nine sample barcoding. We provide improvements of the FCB technique that should be useful for multiplex drug screening and for lymphocyte characterization and perturbations in the diagnosis and during the course of disease. Published 2017 by Wiley Periodicals, Inc., on behalf of International Society for Advancement of Cytometry. This article is a US government work and as such, is in the public domain in the United States of America.
Effects of different nitrogen additions on soil microbial communities in different seasons in a boreal forest
Authors: Yan Guoyong , Xing Yajuan , Xu Lijian , Wang Jianyu , Dong Xiongde , Shan Wenjun , Guo Liang , Wang Qinggui 
Published: July 2017

AbstractIn the global change scenario, nitrogen (N) deposition has the potential to affect the soil microbial communities that play critical roles in ecosystem functioning. Although the impacts of N deposition on soil microbial communities have been reasonably well studied, microorganism responses to the N addition combined with the seasonal change have rarely been reported. This study was conducted to evaluate the effects of different levels of N addition (0, 2.5, 5.0, and 7.5 g N·m−2·yr−1) on soil microbial communities in different seasons (spring, summer, and autumn) in a boreal forest. Our results showed that the soil physical–chemical properties were found to be changed by N addition and seasonal changes were correlated with microbial community structure. The N addition and seasonal changes significantly affect the diversity and abundance of the microbial community, while their interactions only affect the bacterial abundance and the fungal diversity. In addition, our results also provided clear evidence for specific responses of microorganisms to the different N additions and each season. Our findings suggest that the microbial community response to N deposition could be the seasonal change and will strongly correlate with environmental change.
Ending cervical cancer: A call to action
Authors: Aranda Sanchia , Berkley Seth , Cowal Sally , Dybul Mark , Evans Tim , Iversen Katja , Moeti Matshidiso , Osotimehin Babatunde , Peterson Stefan , Piot Peter , Purandare Chittaranjan N. , Sidibé Michel , Trimble Ted , Tsu Vivien Davis 
Published: July 2017

AbstractThe outlook for elimination of the scourge of cervical cancer is bright, because we now have the tools to achieve this goal. In recent years human papillomavirus (HPV) vaccination in high‐income countries has resulted in dramatic decreases in HPV infection and associated cervical disease. If all countries with a substantial burden of disease introduce the vaccine nationally, we can protect the vast majority of women and girls most at risk. For women who are beyond the vaccination target age, progress has been made in screening and treatment for cervical precancer, but we must accelerate this momentum to reduce incidence and mortality worldwide to the very low rates found in wealthier countries. Human and financial resources must be increased and directed to programs that follow best practices and reach all women, including the marginalized or disadvantaged. Seven key actions are recommended. Now is the time for action at national, regional, and global levels.
Comparison of reduced field‐of‐view diffusion‐weighted imaging (DWI) and conventional DWI techniques in the assessment of rectal carcinoma at 3.0T: Image quality and histological T staging
Authors: Peng Yang , Li Zhen , Tang Hao , Wang Yanchun , Hu Xuemei , Shen Yaqi , Hu Daoyu 
Published: July 2017

PurposeTo compare image quality (IQ) of reduced field‐of‐view (rFOV) and full FOV (fFOV) diffusion‐weighted imaging (DWI) sequences at 3T, with histological T staging of rectal cancer as a reference standard.Materials and MethodsIn all, 81 patients with rectal cancer received magnetic resonance (MR) scans (3.0T), including both rFOV and fFOV DWI sequences. The signal‐to‐noise ratio (SNR) and contrast‐to‐noise ratio (CNR) were quantitatively evaluated using the paired t‐test. Two radiologists independently assessed subjective IQ parameters, including image sharpness, distortion, artifacts, lesion conspicuity, and overall subjective IQ of both sequences. The Wilcoxon signed rank test was used to compare subjective IQ scores and tumor apparent diffusion coefficients (ADCs) between DWI sequences. Spearman correlation analysis was used to correlate ADC values and corresponding T staging of rectal cancer.ResultsCNR was significantly higher in rFOV DWI than in fFOV DWI (7.15 ± 2.77 vs. 5.39 ± 2.08, P < 0.001). SNR was significantly higher in rFOV DWI than in fFOV DWI (44.17 ± 11.01 vs. 34.76 ± 13.30, P < 0.001). The subjective IQ parameters of rFOV DWI sequence were rated superior to those of fFOV DWI sequence by both readers (P < 0.001). No significant differences between mean tumor ADC values of both sequences (0.991 ± 0.121 vs. 0.100 ± 0.126 × 10‐3 mm2/s, P = 0.617) were noted. Apart from T1 stage, T staging of rectal cancer was inversely correlated with ADC values of rFOV DWI (r = –0.688, P < 0.001) and fFOV DWI sequences (r = –0.641, P < 0.001).ConclusionThe rFOV DWI sequence provided significantly better IQ and lesion conspicuity than the fFOV DWI sequence. In addition, rFOV and fFOV DWI sequences can be used in evaluation of histological T staging of rectal cancer.Level of Evidence: 3Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:967–975.
A new design methodology to predict wind farm energy production by means of a spiking neural network–based system
Authors: Brusca Sebastian , Capizzi Giacomo , Lo Sciuto Grazia , Susi Gianluca 
Published: July 2017

AbstractIn this paper, a spiking neural network–based architecture for the prediction of wind farm energy production is proposed. The model is also able to evaluate the wake effects due to interactions between the elements of a wind farm on the energy production of the whole farm. This method has been applied to a large wind power plant, composed of 28 turbines and 3 anemometric towers, located in the rural area of Vizzini's municipality in province of Catania, Italy, that is characterised by a complex orography and an extension of 30 km2. For the implementation of this architecture it was used the “NeuCube” simulator. The results show that the presented method can be successfully applied for predictions of wind energy generation in real wind farm also in presence of faults.
Crystal structure of the UBR‐box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding
Authors: Muñoz‐Escobar Juliana , Kozlov Guennadi , Gehring Kalle 
Published: July 2017

AbstractThe UBR‐box is a 70‐residue zinc finger domain present in the UBR family of E3 ubiquitin ligases that directly binds N‐terminal degradation signals in substrate proteins. UBR6, also called FBXO11, is an UBR‐box containing E3 ubiquitin ligase that does not bind N‐terminal signals. Here, we present the crystal structure of the UBR‐box domain from human UBR6. The dimeric crystal structure reveals a unique form of domain swapping mediated by zinc coordination, where three independent protein chains come together to regenerate the topology of the monomeric UBR‐box fold. Analysis of the structure suggests that the absence of N‐terminal residue binding arises from the lack of an amino acid binding pocket.
Structures of designed armadillo repeat proteins binding to peptides fused to globular domains
Authors: Hansen Simon , Kiefer Jonathan D. , Madhurantakam Chaithanya , Mittl Peer R. E. , Plückthun Andreas 
Published: July 2017

AbstractDesigned armadillo repeat proteins (dArmRP) are α‐helical solenoid repeat proteins with an extended peptide binding groove that were engineered to develop a generic modular technology for peptide recognition. In this context, the term “peptide” not only denotes a short unstructured chain of amino acids, but also an unstructured region of a protein, as they occur in termini, loops, or linkers between folded domains. Here we report two crystal structures of dArmRPs, in complex with peptides fused either to the N‐terminus of Green Fluorescent Protein or to the C‐terminus of a phage lambda protein D. These structures demonstrate that dArmRPs bind unfolded peptides in the intended conformation also when they constitute unstructured parts of folded proteins, which greatly expands possible applications of the dArmRP technology. Nonetheless, the structures do not fully reflect the binding behavior in solution, that is, some binding sites remain unoccupied in the crystal and even unexpected peptide residues appear to be bound. We show how these differences can be explained by restrictions of the crystal lattice or the composition of the crystallization solution. This illustrates that crystal structures have to be interpreted with caution when protein–peptide interactions are characterized, and should always be correlated with measurements in solution.
Effects of pyriproxyfen on wild populations of the housefly, Musca domestica, and compatibility with its principal parasitoids
Authors: Biale Haim , Geden Christopher J , Chiel Elad 
Published: July 2017

AbstractBACKGROUNDThe housefly, Musca domestica L., is an important pest of animal agriculture. Effective fly management requires integration of manure management, mass trapping, biological control, and selective insecticide use. Insecticidal control of houseflies is difficult due to the rapidity of resistance development, yet the insect growth regulator pyriproxyfen (PPF) is one of few insecticides that may still be effective. Here, we tested the susceptibility of wild housefly populations in the USA and in Israel to PPF, as well as the effect of PPF on housefly parasitoids of the genera Muscidifurax and Spalangia.RESULTSMost housefly populations from both countries were completely eliminated at PPF concentrations of 100 mg kg–1 (USA) and 600 mg kg–1 (Israel). One population from each country exhibited initial levels of PPF tolerance. PPF efficacy significantly decreased in cow manure. Emergence rates of parasitoids developing in PPF‐treated hosts at concentrations of ≥600 mg kg–1 were significantly affected, whereas other fitness parameters were moderately to non‐affected.CONCLUSIONSPPF is still an effective tool for housefly control, but resistance management practices should be employed to avoid resistance. PPF is compatible with principal housefly parasitoids at concentrations <600 mg kg–1, and is suitable for use in integrated pest management. © 2017 Society of Chemical Industry
Effects of imperfect testing on presence‐absence sampling plans
Authors: Santos‐Fernández Edgar , Govindaraju Kondaswamy , Jones Geoff 
Published: July 2017

AbstractSampling inspection plans are used in the food industry to determine whether a batch of food is contaminated or not. Testing for pathogens is mandatory in several foodstuffs because some bacteria pose a significant risk to human health, even when these are consumed in minute quantity. Test performance measures such as sensitivity and specificity are generally ignored in microbiological risk assessment and food quality assurance. In this research, we examine the impact of imperfect analytical tests on sampling inspection plans for presence‐absence characteristics. We discuss several plausible scenarios and assess the risk for the consumers. The method is illustrated using data collected over 2 years forCronobacterspp (formerlyEnterobactersakazakii) in skimmed milk powder. The probability of contamination and the test sensitivity and specificity are estimated using Bayesian methods. We examine the sampling plans proposed by the Codex Alimentarius and by the New Zealand's Ministry of Primary Industries for this pathogen. A cost analysis is performed to show the economic loss due to measurement errors. We describe the strengths and limitations of these plans under different conditions and propose a plan that could provide better protection to the consumers as well as to the producers.