bluuebunny/crossref_metadata_2025_split huggingface dataset:
Qualitative exploration of determinants of active mobility and social participation in Urban neighborhoods: individual perceptions over objective factors?
Authors: Bollenbach Lukas , Kanning Martina , Niermann Christina 
Published: October 2024

Abstract
Background
Urban neighborhood environments play an important role in facilitating or hindering residents to engage in active mobility and social participation. However, while there is much quantitative research, in-depth knowledge that contextualizes residents’ subjective perceptions of barriers and facilitators of active mobility and social participation is still insufficient. Therefore, a qualitative approach was used to collect subjectively perceived barriers and facilitators of active mobility and social participation of residents from different neighborhoods with objectively determined high vs. low walkability. Furthermore, to better understand (non) concordance of objective environmental characterizations and actual levels of behavior, low and high walkability neighborhood-specific barriers, proposed improvements, and particularities that determine (non) engagement in active mobility and social participation were explored.

Methods
Three focus groups (N = 6, N = 6, and N = 5) with 17 participants (7 women, 10 men) aged 21–64 (mean age 43.4 ± 14,6 years) were conducted utilizing a pre-structured interview guideline. Participants lived in 11 different neighborhoods with either high or low objectively determined walkability. The focus groups were transcribed verbatim, followed by a thematic analysis of the content with deductive and inductive code categories, utilizing the MAXQDA software.

Results
Notable was the consensus of many perceived barriers and facilitators of active mobility and social participation along with their assignability to the same context (points-of-interest, infrastructure; safety, communication, community; topography, physical compositions, weather, aesthetics; personal / individual attitudes, influences, evaluations). Another main finding was that high and low walkability neighborhood-specific particularities were revealed that are in contrast to some objective characterizations of walkability: For example, too high density can inhibit active mobility, and too many options can inhibit social participation.

Conclusions
The consensus of many barriers and facilitators of active mobility and social participation suggests that valuable synergies could be created by coordinating interventions aiming to promote both active mobility and social participation in urban neighborhoods. Also, considering subjective perceptions of residents helps to identify neighborhood-specific factors that determine (non) engagement in active mobility and social participation. The findings can help city planners and public health officials improve the promotion of active mobility and social participation in the creation of health-enhancing urban neighborhoods.
Crime reporting and victim satisfaction with the police: a large-scale study among victims of crime in the Netherlands
Authors: Jansen Roselle P. , Ruiter Stijn , van Steden Ronald 
Published: October 2024

Abstract
Objectives
There is a rich body of research on how and why victims report crime to police, but little is known about the crime reporting process itself. This paper explores the relationship between victim satisfaction with the police after reporting crime and the various reporting channels victims used, as well as the subsequent police response.

Methods
We capitalize on a large-scale nationwide survey among victims in the Netherlands (N = 25,760). Using linear regression, we test how victim satisfaction with the police relates to the reporting channel used, follow-up contact by the police, and action taken by the police while controlling for type of crime, its impact on victims, their needs and their sociodemographic characteristics.

Results
The model explains 38% of the variance in victim satisfaction. The crime reporting channel and subsequent police response to crime reports show largest effects. When victims had in-person conversations with the police, the police reported back to them, and took further action, victims were most satisfied.

Conclusions
This study shows the importance of how police operate during and after victims report a crime for their satisfaction with police. The results suggest that police may be able to positively affect victim satisfaction by taking relatively simple measures. More research is needed to test this hypothesis using (quasi)experimental designs.
Natural killer cell-based cancer immunotherapy: from basics to clinical trials
Authors: Shi Yinghong , Hao Donglin , Qian Hui , Tao Zhimin 
Published: October 2024

AbstractCellular immunotherapy exploits the capacity of the human immune system in self-protection and surveillance to achieve the anti-tumor effects. Natural killer (NK) cells are lymphocytes of innate immune system and they display a unique inherent ability to identify and eliminate tumor cells. In this review, we first introduce the basic characteristics of NK cells in the physiological and pathological milieus, followed by a discussion of their effector function and immunosuppression in the tumor microenvironment. Clinical strategies and reports regarding NK cellular therapy are analyzed in the context of tumor treatment, especially against solid tumors. Given the widely studied T-cell therapy in the recent years, particularly the chimeric antigen receptor (CAR) T-cell therapy, we compare the technical features of NK- and T-cell based tumor therapies at the clinical front. Finally, the technical challenges and potential solutions for both T and NK cell-based immunotherapies in treating tumor malignancies are delineated. By overviewing its clinical applications, we envision the NK-cell based immunotherapy as an up-and-comer in cancer therapeutics.
I see you: teacher analytics with GPT-4 vision-powered observational assessment
Authors: Lee Unggi , Jeong Yeil , Koh Junbo , Byun Gyuri , Lee Yunseo , Lee Hyunwoong , Eun Seunmin , Moon Jewoong , Lim Cheolil , Kim Hyeoncheol 
Published: October 2024

AbstractThis preliminary study explores how GPT-4 Vision (GPT-4V) technology can be integrated into teacher analytics through observational assessment, aiming to improve reflective teaching practice. Our study develops a Video-based Automatic Assessment System (VidAAS) powered by GPT-4V. This approach uses Generative Artificial Intelligence (GenAI) to provide detailed insights into classroom dynamics. Our study encompasses various methods with multiple steps: a comprehensive literature review, prototype development of the VidAAS, and usability testing with in-service teachers. The study findings reveal that VidAAS demonstrates high accuracy in evaluating skills in the behavioral (psychomotor) domain and offers comprehensive explanations for each assessment. While showing promise in these areas, the system also indicates potential for further enhancement in processing speed and refinement in assessing cognitive and affective domains. We discuss how VidAAS supports teachers’ reflection-in-action and reflection-on-action, emphasizing the need to balance AI-driven insights and human judgment. Our study findings also guide future research avenues for VidAAS design, implementation, and integration in teacher analytics, underscoring GPT-4V’s potential for real-time, scalable feedback and a deeper classroom understanding.
Development and validation of an innovative administration system to facilitate controlled holmium-166 microsphere administration during TARE
Authors: van Wijk Meike W. M. , van Wolfswinkel Gerhard , Arntz Mark J. , Janssen Marcel J. R. , Roosen Joey , Nijsen J. Frank W. 
Published: October 2024

Abstract
Background
To develop and validate a novel administration device for holmium-166 transarterial radioembolisation (TARE) with the purpose of facilitating controlled fractional microsphere administration for a more flexible and image-guided TARE procedure.

Methods
A Controlled Administration Device (CAD) was developed using MR-conditional materials. The CAD contains a rotating syringe to keep the microspheres in suspension during administration. Different rotational speeds were tested ex vivo to optimise the homogeneity of microsphere fractions administered from the device. The technical performance, accuracy, and safety was validated in three patients in a clinical TARE setting by administering a standard clinical dose in 5 fractions (identifier: NCT05183776). MRI-based dosimetry was used to validate the homogeneity of the given fractions in vivo, and serious adverse device event ((S)A(D)E) reporting was performed to assess safety of the CAD.

Results
A rotational speed of 30 rpm resulted in the most homogeneous microsphere fractions with a relative mean deviation of 1.1% (range: -9.1-8.0%). The first and last fraction showed the largest deviation with a mean of -26% (std. 16%) and 7% (std. 13%). respectively. In the three patient cases the homogeneity of the microsphere fractions was confirmed given that MRI-based dosimetry showed near linear increase of mean absorbed target liver dose over the given fractions with R2 values of 0.98, 0.97 and 0.99. No (S)A(D)E’s could be contributed to the use of the CAD.

Conclusions
The newly developed CAD facilitates safe and accurate fractional microsphere administration during TARE, and can be used for multiple applications in the current and future workflows of TARE.
Floral morphology and pollen placement strategies of bat-pollinated flowers: a comparative analysis within a guild of chiropterophilous plants in a neotropical dry forest
Authors: Pontes Cristina Adriane de Souza , Machado Isabel Cristina , Domingos-Melo Arthur 
Published: October 2024

Abstract
Background
Synchronopatric plant species, coexisting and flowering simultaneously, often engage in intense competition for pollen deposition on shared pollinators. This study focuses on the intricate dynamics of chiropterophilous flowers within the neotropical bat-pollination plant guild, specifically investigating the mechanical fit of reproductive structures to pollinating bats at the community level.

Methods
Utilizing a diverse guild of bat-pollinated plant species from the Caatinga, the largest dry forest in the Neotropics, our research integrates various key components. Initially, we identified specific contact sites for floral reproductive structures on the bat's body, exploring diverse pollen placement strategies. Subsequent efforts involved characterizing floral traits within the guild and examining their associations with different pollen placement strategies. Precision in the contact of floral reproductive structures was estimated, and findings were integrated by associating pollen placement strategies and precision with the investment in pollen production.

Results
We found that certain bat body parts, particularly the face and neck, were more frequently contacted by reproductive structures. The three identified categories of pollen placement strategies were evenly distributed among plant species, each linked to specific floral traits. Notably, the absence of oriented herkogamy prevailed in 70% of the species. Morphometric analyses unveiled significant variations in operative distances among species, emphasizing exceptional variability in certain outliers. While precision in pollen transfer was influenced by key factors, surprisingly, investment in pollen production did not differ among plants with distinct pollen placement strategies. Furthermore, it showed no correlation with fundamental accuracy.

Conclusions
The subsequent exploration delves into the intricate associations between distinct floral characteristics and various pollen placement strategies, shaping the complex pollen landscape on bat bodies. This research provides valuable insights into the community-level dynamics of chiropterophilous flowers in the Caatinga Dry Forest, emphasizing the role of different pollen deposition strategies in facilitating the coexistence of multiple plant species within the chiropterophilous guild.
Isolated IgG4-related Infundibulo-hypophysitis
Authors: Allen Margaret E , Beck Ryan T , Zwagerman Nathan T , Coss Dylan , Fisco Amy , Ioachimescu Adriana G 
Published: October 2024

Abstract
A 72-year-old man presented with several months of weakness, poor appetite, and depressed moods. Laboratory tests indicated central hypocortisolism, hypothyroidism and hypogonadism, and mild hyperprolactinemia. Imaging indicated a homogenously enhancing solid suprasellar mass inseparable from the hypothalamus and contiguous with a thickened proximal infundibulum. Neuro-ophthalmological evaluation was normal. Symptoms improved with hydrocortisone, levothyroxine, and testosterone replacement. After 6 months, transsphenoidal biopsy was performed due to mass enlargement and revealed fibrosis, lymphoplasmacytic infiltration, and CD138 and IgG4 staining. The levels of serum IgG4, complement, inflammatory markers, protein electrophoresis, amylase, and lipase and imaging of the chest, abdomen, and thyroid were unremarkable. After 1 month of prednisone therapy (starting dose 40 mg/day), the mass significantly involuted and remained stable afterward. Prednisone was gradually tapered to 5 mg daily over 10 weeks. During 22 months of follow-up, no systemic IgG4 disease was detected. Glucocorticoid, thyroid, and testosterone replacement was continued. This case of isolated IgG4-related hypophysitis illustrates the variable presentation that may not entail vasopressin deficiency or clinical mass effect. This entity should be considered in the differential diagnosis of suprasellar masses even in the absence of IgG4 systemic disease or characteristic serology. Management entails multidisciplinary collaboration and long-term follow-up.
Burosumab, a Transformational Treatment in a Pediatric Patient With Cutaneous-Skeletal Hypophosphatemia Syndrome
Authors: da Silva Paulo Cesar Alves , Giombelli Vinicius Rene , Galvão Tessaro Fernando Henrique 
Published: October 2024

Abstract
Cutaneous-skeletal hypophosphatemia syndrome (CSHS) is a rare disorder characterized by the presence of melanocytic nevi, dysplastic cortical bony lesions, and fibroblast growth factor 23 (FGF23)-mediated hypophosphatemic rickets. Herein, we describe the diagnosis of an 8-year-old girl presenting with short stature, reduced lower limb mobility, and abnormal gait due to muscle weakness and constant pain in the legs. Biochemical parameters demonstrated hypophosphatemia, hyperphosphaturia, slight increase in parathyroid hormone (PTH), high levels of alkaline phosphatase, and elevated FGF23. Burosumab improved phosphate-wasting, serum phosphorus, alkaline phosphatase, and PTH, followed by a significant mineralization in vertebral bodies evidenced by radiographic assessment. Our report shows a long-term follow-up of CSHS with a notable improvement promoted by an anti-FGF23 therapy.
Postnatal Dysregulation of Androgens in Extremely Preterm Male Infants
Authors: Nilsson Anders K , Sjöbom Ulrika , Landin Andreas , Andersson Mats X , Ryberg Henrik , Pivodic Aldina , Löfqvist Chatarina , Sävman Karin , Poutanen Matti , Ohlsson Claes , Hellström Ann 
Published: October 2024

Abstract

Context
Neurodevelopmental impairments are common among survivors of extremely preterm birth, particularly in males. Hyperactivation of the hypothalamic–pituitary–gonadal (HPG) axis has been suggested as an underlying cause, but this has been poorly investigated.

Objective
Establish levels and temporal changes in circulating androgens in extremely preterm infant males.

Methods
Observational cohort study analyzing cord blood serum (n = 25) and postnatal plasma (n = 13) collected from day 0 until week 11 from infant males born at 22.8-27.9 weeks gestational age. Testosterone and dihydrotestosterone (DHT) were determined using gas chromatography mass spectrometry, sex hormone–binding globulin (SHBG) with an enzyme-linked immunosorbent assay, and follicle-stimulating hormone (FSH) and luteinizing hormone (LH) with the Luminex xMAP multiplex assay.

Results
Testosterone and DHT levels were higher on day 0 (median 4.27 and 0.30 ng/mL) than in cord blood (0.15 and 0.01 ng/mL) (P &lt; .001 for both). Levels of the hormones then declined rapidly until day 5 (median 0.16 and 0.12 ng/mL), then remained relatively constant throughout the study period. Median levels of testosterone and DHT across the whole study period were approximately 6-fold higher than reported in utero levels. FSH and LH showed similar postnatal patterns as the androgens. SHBG steadily increased over time, and, as a result, the fraction of bioavailable testosterone declined with infant postnatal age.

Conclusion
The HPG axis is activated immediately after birth in extremely preterm infant males, resulting in an androgen pulse occurring several months earlier than during a normal pregnancy. The long-term implications of high androgen exposure during a sensitive neurodevelopmental period warrant further studies.
Decreased Incidence of Radial Artery Vasospasm Using a Distal Transradial Approach in Diagnostic Cerebral Angiography: A Comparison of 200 Consecutive Cases
Authors: Hubbard Zachary S. , Cunningham Conor M. , Abo Kasem Rahim , Sowlat Mohammad-Mahdi , Muthana Ahmed , Isidor Julio , Porto Guilherme , Kicielinski Kimberly , Al Kasab Sami , Lena Jonathan , Spiotta Alejandro M. 
Published: October 2024

BACKGROUND AND OBJECTIVES:
Radial artery vasospasm is a common complication of radial artery catheterization. During the implementation of distal transradial approach (dTRA), we observed a decreased incidence of radial artery vasospasm on radial artery angiography following access that was not well detailed in the literature. The purpose of this study was to characterize the phenomenon of radial artery vasospasm in the context of different radial artery access points for diagnostic cerebral angiography.

METHODS:
We retrospectively reviewed consecutive patients undergoing diagnostic cerebral angiography from September 2023 to March 2024. Hundred conventional transradial approach (cTRA) and 100 dTRA diagnostic cerebral angiograms were performed. Following sheath insertion, all angiographic runs were reviewed, and a classification scheme was used to detail radial artery vasospasm occurrence.

RESULTS:
Radial artery vasospasm was lower in the dTRA approach compared with the cTRA approach (P = .019). A change in radial artery diameter was noted in 47 (47%) patients in the cTRA group vs 28 (28%) patients in the dTRA group. Radial artery diameter distal to the sheath was smaller in the cTRA group (2.30 ± 0.41) compared with the dTRA group (2.42 ± 0.48) (P = .021). Patients with Grade II/III spasm were younger (58 years vs 62 years; P = .029) and had a higher percentage of females (77.3% vs 62.4%; P = .030). Grade II/III spasm patients had a higher percentage of the cTRA approach compared with the dTRA approach (62.7% vs 42.4%; P = .008). These procedures were significantly longer with Grade II/III procedure time of 18:00 minutes vs 15.59 minutes in the Grade I group. Number of vessels catheterized was not significantly different between groups (P = .262).

CONCLUSION:
dTRA for diagnostic cerebral angiography is associated with a lower incidence of radial artery vasospasm compared with cTRA. Operators seeking to obviate radial artery vasospasm may consider using the dTRA approach for diagnostic cerebral angiography.
Use of a Single-Fiber Optical Probe for the Detection of Tumor Fluorescence in High-Grade Glioma
Authors: Dablouk Mohamed Osman , Buckley Kevin , Eustace David , Jansen Michael , Bermingham Niamh , Lim Chris , Kamel Mahmoud , Mohammed Wail , O'Sullivan Michael Gerard Joseph 
Published: October 2024

BACKGROUND AND OBJECTIVES:
High-grade glioma (HGG) is the most common primary brain tumor in adults. The overall median survival is between 14 and 16 months. Fluorescence-guided surgery by detection of protoporphyrin IX (PpIX) fluorescence has been shown to improve the extent of resection, translating to improved progression-free survival. Microscope-based fluorescence detection techniques are associated with several pain points, some of which may be addressed by using contact-based spectroscopy. We aimed to investigate the accuracy of an optical fiber at detecting PpIX fluorescence by performing real-time spectroscopy in patients with HGG.

METHODS:
Adult patients undergoing fluorescence-guided surgery for suspected HGG were recruited prospectively. Intraoperatively, samples from cortex, white matter, and tumor were taken. These samples were interrogated using standard white and blue light microscope techniques and the optical fiber. These specimens were then assessed by neuropathology to determine whether the tumor tissue was present within them.

RESULTS:
We collected 89 samples from 28 patients. There was an equal ratio of men to women, with a median age of 66.5 years. The accuracy of the probe for detecting PpIX fluorescence was 75.9%, compared with 56.6% for the operating microscope, with a significant improvement in sensitivity (χ2 = 11.84, P < .001).

CONCLUSION:
The optical fiber probe was more accurate than the operating microscope for detecting PpIX fluorescence. This technology has potential value in improving the accuracy of fluorescence-guided surgery and has potential practical benefits relating to surgical workflow.
Working Paper 54: Targeting illicit wealth through non-conviction based forfeiture
Authors: Solórzano Oscar 
Published: October 2024

This paper explores the wide variety of non-conviction based (NCB) forfeiture laws in Latin America, with a special focus on the region’s predominant model, Extinción de dominio. It argues that NCB forfeiture legislation, which allows for the recovery of stolen assets outside of criminal proceedings, can contribute significantly to a state’s policy response to rampant economic and organised crime. The paper emphasises the importance of critically reviewing and harmonising domestic practices of NCB forfeiture aroundemerging standards, so that they can reach their large potential. Ensuring their alignment with international human rights and other recognised norms and rules ultimately builds trust, lends legitimacy and fosters judicial cooperation in international NCB forfeiture cases.
About this report
This paper is published as part of the Basel Institute on Governance Working Paper series, ISSN: 2624-9650. You may share or republish the Working Paper under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Suggested citation: Solórzano, Oscar. 2024. ‘Targeting illicit wealth through non-conviction based forfeiture: Identifying human rights and other standards for Latin America.’ Working Paper 54, Basel Institute on Governance. Available at: baselgovernance.org/publications/wp-54.
Disclaimer
This Working Paper is intended for general informational purposes and does not constitute and/or substitute legal or other professional advice. The contents are the sole responsibility of the author and do not necessarily reflect the views and the official position of the Basel Institute on Governance, its donors and partners, or the University of Basel.