bluuebunny/crossref_metadata_2025_split huggingface dataset:
I-TRACH: Validating A Tool for Predicting Prolonged Mechanical Ventilation
Authors: Clark Paul A. , Inocencio Ryan C. , Lettieri Christopher J. 
Published: November 2016

Purpose: We previously developed a bedside model (I-TRACH), which used commonly obtained data at the time of intubation to predict the duration of mechanical ventilation (MV). We now sought to validate this in a prospective trial. Methods: A prospective, observational study of 225 consecutive adult medical intensive care unit patients requiring MV. Utilizing the original 6 variables used in the I-TRACH model (Intubation in the ICU, Tachycardia [heart rate > 110], Renal dysfunction [blood urea nitrogen > 25], Acidemia [pH < 7.25], Creatinine [>2.0 or >50% increase from baseline values], and decreased HCO3 [<20]), we (1) confirmed that these were still predictive of length of MV by multivariate analysis and (2) assessed the correlation between the number of criteria met and the subsequent duration of MV. In addition, we compared the performance of I-TRACH to Acute Physiology Age Chronic Health Evaluation-II and III, Sequential Organ Failure Assessment, and Acute Physiology Score as predictors of length of MV. Results: Mean age was 62.6 ± 18.7 years, with a mean duration of MV of 5.8 ± 5.7 days. The number of I-TRACH criteria met directly correlated with the duration of MV. Individuals with ≥4 criteria were significantly more likely to require MV >7 and >14 days. Similarly, those who remained on ventilators for both >7 and >14 days met significantly more I-TRACH criteria than those requiring shorter durations of MV (1.7 ± 1.3 vs 2.8 ± 1.3 vs 3.8 ± 1.3 criteria, P < .001). I-TRACH performed better than all other models used to predict the duration of MV. Conclusion: Similar to our previous retrospective study, these findings validate I-TRACH in determining the subsequent need for MV >7 and >14 days at the time of intubation.
Can We Help Care Providers Communicate More Effectively With Persons Having Dementia Living in Long-Term Care Homes?
Authors: McGilton Katherine S. , Rochon Elizabeth , Sidani Souraya , Shaw Alexander , Ben-David Boaz M. , Saragosa Marianne , Boscart Veronique M. , Wilson Rozanne , Galimidi-Epstein Karmit K. , Pichora-Fuller M. Kathleen 
Published: November 2016

Background: Effective communication between residents with dementia and care providers in long-term care homes (LTCHs) is essential to resident-centered care. Purpose: To determine the effects of a communication intervention on residents’ quality of life (QOL) and care, as well as care providers’ perceived knowledge, mood, and burden. Method: The intervention included (1) individualized communication plans, (2) a dementia care workshop, and (3) a care provider support system. Pre- and postintervention scores were compared to evaluate the effects of the intervention. A total of 12 residents and 20 care providers in an LTCH participated in the feasibility study. Results: The rate of care providers’ adherence to the communication plans was 91%. Postintervention, residents experienced a significant increase in overall QOL. Care providers had significant improvement in mood and perceived reduced burden. Conclusion: The results suggest that the communication intervention demonstrates preliminary evidence of positive effects on residents’ QOL and care providers’ mood and burden.
Albertiniite, Fe2+(SO3)·3H2O, a new sulfite mineral species from the Monte Falò Pb-Zn mine, Coiromonte, Armeno Municipality, Verbano Cusio Ossola Province, Piedmont, Italy
Authors: Vignola P. , Gatta G. D. , Rotiroti N. , Gentile P. , Hatert F. , Baijot M. , Bersani D. , Risplendente A. , Pavese A. 
Published: November 2016

AbstractAlbertiniite, Fe2+(SO3)·3H2O, is a new Fe2+ sulfite trihydrate, related chemically to gravegliaite. It occurs at the Monte Falò Pb-Zn mine near Coiromonte, in the Armeno Municipality, Verbano–Cusio–Ossola Province, Italy. It is an intermediate product of oxidation between iron sulfides and sulfates, forming monoclinic, colourless to pale yellow, transparent crystals with a vitreous lustre. The mineral occurs associated with stolzite, pyromorphite, hinsdalite, plumbogummite, gibbsite, scheelite and jarosite on brittle fractures of quartz veins or chlorite-schist. Albertiniite is optically biaxial (+) with 2V(meas) ≈ 40° and 2V(calc) = 66°. The measured refractive indices, using sodium light (589 nm) are: α = 1.612(2)°, β = 1.618(2)° and γ = 1.632(2)°. The optical axis plane is parallel to the perfect {010} cleavage plane. It is non-fluorescent under shortwave (254 nm) or longwave (366 nm) ultraviolet light. The calculated density is 2.469 g cm–3 (from the crystal-structure refinement), or 2.458 g cm–3 (from the chemical analysis and the single-crystal unit-cell parameters). The empirical formula is (average of 16 spots and based on 3 anhydrous oxygen apfu) (Ca0.001Mg0.001Na0.003)∑1.061(S0.971O3)·2.84H2O, with the H2O content calculated by difference to 100 wt.%. Albertiniite is monoclinic, with space group P21/n. Its unit-cell parameters are: a = 6.633(1), b = 8.831(1), c = 8.773(1) Å, β = 96.106(8)° and V = 511.0(1) Å3, with Z = 4. The eight strongest measured lines in the powder X-ray diffraction pattern are [d in Å, (I/I0), (hkl)]: 4.072 (100) (1̄11), 3.539 (93) (1̄12), 5.533 (27) (1̄01), 6.167 (14) (011), 2.830 (14) (211), 4.998 (14) (101), 4.353 (12) (111) and 3.897 (12) (012). The mineral, which has been approved by the CNMNC, number IMA2015-004, is named albertiniite in honour of Claudio Albertini, an Italian mineral collector and expert in the systematic mineralogy of the Alps and pegmatites.
Water incorporation in garnets from ultrahigh pressure eclogites at Shuanghe, Dabieshan
Authors: Liu Xiang-Wen , Xie Zhan-Jun , Wang Lu , Xu Wei , Jin Zhen-Min 
Published: November 2016

AbstractThe hydrogen concentration and composition of garnets in the ultrahigh pressure eclogites at Shuanghe, eastern Dabieshan, were investigated using Fourier transform infrared spectroscopy and electron microprobe analysis. The OH absorption bands can be divided into four groups: (1) 3635–3655 cm–1; (2) 3600–3630 cm–1; (3) 3540–3580 cm–1; and (4) 3400–3450 cm–1and the water content ranges from 45 to 2529 ppm. Based on the behaviour of the OH absorption band and the relationship between water content and the composition of garnets, the samples can be divided into two classes: samples with >400 ppm H2O and samples with ≤400 ppm H2O. The water content of the former shows an obvious positive correlation with Ca atoms and a negative correlation with the Si, Mg and Fe2+atoms per 12 anions, whereas the water content of the latter shows no obvious linear correlation with cations. It is concluded that the major mechanism of hydroxyl incorporation in garnets with >400 ppm H2O is by the coupled substitution 4H +Z□ → □+ZSi in the tetrahedral site, and that several mechanisms are responsible for OH incorporation in garnets with ≤400 ppm H2O.
Oxo-mangani-leakeite from the Hoskins mine, New South Wales, Australia: occurrence and mineral description
Authors: Oberti Roberta , Boiocchi Massimo , Hawthorne Frank C. , Ball Neil A. , Ashley Paul M. 
Published: November 2016

AbstractOxo-mangano-leakeite, a newly approved end-member of the amphibole supergroup (IMA-CNMNC 20150-35), has been found in a rock containing manganese silicate and oxide at the Hoskins Mine, a Mn deposit 3 km west of Grenfell, New South Wales. The end-member formula of oxo-mangani-leakeite is ANaBNa2C(Mn3+4Li)TSi8 O22WO2, which would require SiO2 53.15, Mn2O3 34.91, Li2O 1.66, Na2O 10.28, total 100.00 wt.%. The empirical formula derived for the sample of this work from electron and ion microprobe analysis using constraints resulting from single-crystal structure refinement is A(Na0.65K0.36)∑ = 1.01B(Na1.94Ca0.06)∑ = 2.00C(Mg1.60Zn0.01 Li0.58)∑ = 5.01T(Si7.98Al0.02)∑ = 8.00O22W(O1.34OH0.66)∑ = 2.00. Oxo-mangano-leakeite is biaxial (–), with α = 1.681, β = 1.712, γ = 1.738, all ± 0.002, and 2V (meas.) = 81.0(4)°, 2V (calc.) = 83.5°. The unit-cell dimensions are a = 9.875(5), b = 17.873(9), c = 5.295(2) Å, β = 104.74(3)°, V = 903.8 (7) Å3; the space group is C2/m, with Z = 2. The strongest ten reflections in the powder X-ray pattern [d values (in Å), I, (hkl)] are: 8.423, 100, (110); 3.377, 46, (131); 4.461, 40, (040); 4.451, 40, (021); 3.134, 37, (310); 2.694, 37, (151); 2.282, 27, (); 2.734, 25, (31); 2.575, 24, (061); 2.331, 24, [() ()]. The holotype material is deposited in the Canadian Museum of Nature, Ottawa, under the catalogue number CMNMC 86895.
Kuratite, Ca4(Fe2+10Ti2)O4[Si8Al4O36], the Fe2+-analogue of rhönite, a new mineral from the D'Orbigny angrite meteorite
Authors: Hwang S.-L. , Shen P. , Chu H.-T. , Yui T.-F. , Varela M.-E. , Iizuka Y. 
Published: November 2016

AbstractKuratite, ideally Ca4(Fe2+10Ti2)O4[Si8Al4O36], the Fe2+-analogue of rhönite and a new member of the sapphirine supergroup, was identified from the D'Orbigny angrite meteorite by electron microscopy and micro-Raman spectroscopy. Based on the least-squares refinement of 25 d-spacings measured from selected-area electron diffraction patterns of 11 zone axes, the symmetry of kuratite was shown to be triclinic (space group by analogy to rhönite) with a = 10.513(7), b = 10.887(7), c = 9.004(18) Å, α = 105.97(13), β = 96.00(12), γ = 124.82(04)°, V = 767 ± 2 Å3 and Z = 1 for the 40 oxygen formula. The empirical formula based on eight electron microprobe analyses is (Ca3.88Na0.02REE3+0.03Mn0.03Mg0.01Ni0.02Zn0.01Sr0.01)∑4.01 (Fe2+9.989.9Ti2.00)∑11.98(Si7.80Al3.52Fe3+0.64P0.05S0.02)∑12.03O39.98F0.01Cl0.01. The simplified formula is Ca4(Fe2+10Ti2)O4[Si8Al4O36]. Micro-Raman spectroscopy showed four main bands resembling those of lunar rhönite but with higher frequencies due to different chemical composition. Analogous to the occurrence of kuratite in terrestrial basaltic rocks, kuratite coexisting with Al, Ti-bearing hedenbergite, ulvöspinel, iron-sulfide, tsangpoite, Ca-rich fayalite and kirschsteinite in D'Orbigny angrite most probably was formed at >1000°C by rapid cooling of an interstitial melt, which is subsilicic, almost Mg-free but enriched in Al-P-Ca-Ti-Fe.
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs
Authors: Corat Marcus A. F. , Schlums Heinrich , Wu Chuanfeng , Theorell Jakob , Espinoza Diego A. , Sellers Stephanie E. , Townsley Danielle M. , Young Neal S. , Bryceson Yenan T. , Dunbar Cynthia E. , Winkler Thomas 
Published: November 2016

Key Points
GPIposCD56dim NK cells with an adaptive phenotype persist long-term in PNH patients. Clonal tracking of adaptive NK cells in PNH patients suggests maintenance independent of HSPCs.
A phase 3 randomized trial comparing inolimomab vs usual care in steroid-resistant acute GVHD
Authors: Socié Gérard , Vigouroux Stéphane , Yakoub-Agha Ibrahim , Bay Jacques-Olivier , Fürst Sabine , Bilger Karin , Suarez Felipe , Michallet Mauricette , Bron Dominique , Gard Philippe , Medeghri Zakaria , Lehert Philippe , Lai Chinglin , Corn Tim , Vernant Jean-Paul 
Published: November 2016

Key PointsIn steroid-resistant acute GVHD 1-year survival without changing baseline therapy was not different after inolimomab vs ATG. Using current care, the expected 1-year survival of these patients lies in the 55% range.
BCR-ABL1 gene rearrangement as a subclonal change in ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia
Authors: Dun Karen A. , Vanhaeften Rob , Batt Tracey J. , Riley Louise A. , Diano Giuseppe , Williamson Jan 
Published: November 2016

Key PointsBCR-ABL1 rearrangement as a subclonal change in ETV6-RUNX1–positive B-ALL is a rare occurrence not previously reported. The prognosis of this rare subclonal change has not been determined, yet inclusion of tyrosine kinase inhibitors in treatment is ubiquitous.
Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment
Authors: Serra Sara , Vaisitti Tiziana , Audrito Valentina , Bologna Cinzia , Buonincontri Roberta , Chen Shih-Shih , Arruga Francesca , Brusa Davide , Coscia Marta , Jaksic Ozren , Inghirami Giorgio , Rossi Davide , Furman Richard R. , Robson Simon C. , Gaidano Gianluca , Chiorazzi Nicholas , Deaglio Silvia 
Published: November 2016

Key Points
Hypoxia shapes the CLL lymph node microenvironment by acting through the A2A adenosine receptor. Inhibiting the A2A adenosine receptor counteracts the effects of hypoxia on CLL cells, macrophages, and T lymphocytes.
Reciprocal Crosstalk Between Autophagic and Endocrine Signaling in Metabolic Homeostasis
Authors: Sinha Rohit A. , Singh Brijesh K. , Yen Paul M. 
Published: November 2016

AbstractAutophagy is a cellular quality control and energy-providing process that is under strict control by intra- and extracellular stimuli. Recently, there has been an exponential increase in autophagy research and its implications for mammalian physiology. Autophagy deregulation is now being implicated in many human diseases, and its modulation has shown promising results in several preclinical studies. However, despite the initial discovery of autophagy as a hormone-regulated process by De Duve in the early 1960s, endocrine regulation of autophagy still remains poorly understood. In this review, we provide a critical summary of our present understanding of the basic mechanism of autophagy, its regulation by endocrine hormones, and its contribution to endocrine and metabolic homeostasis under physiological and pathological settings. Understanding the cross-regulation of hormones and autophagy on endocrine cell signaling and function will provide new insight into mammalian physiology as well as promote the development of new therapeutic strategies involving modulation of autophagy in endocrine and metabolic disorders.
Bilateral Testicular Tumors Resulting in Recurrent Cushing Disease After Bilateral Adrenalectomy
Authors: Puar Troy , Engels Manon , van Herwaarden Antonius E. , Sweep Fred C. G. J. , Hulsbergen-van de Kaa Christina , Kamphuis-van Ulzen Karin , Chortis Vasileios , Arlt Wiebke , Stikkelbroeck Nike , Claahsen-van der Grinten Hedi L. , Hermus Ad R. M. M. 
Published: November 2016

Abstract

Context:
Recurrence of hypercortisolism in patients after bilateral adrenalectomy for Cushing disease is extremely rare.

Patient:
We present a 27-year-old man who previously underwent bilateral adrenalectomy for Cushing disease with complete clinical resolution. Cushingoid features recurred 12 years later, with bilateral testicular enlargement. Hormonal tests confirmed adrenocorticotropic hormone (ACTH)-dependent Cushing disease. Surgical resection of the testicular tumors led to clinical and biochemical remission.

Design and Results:
Gene expression analysis of the tumor tissue by quantitative polymerase chain reaction showed high expression of all key steroidogenic enzymes. Adrenocortical-specific genes were 5.1 × 105 (CYP11B1), 1.8 × 102 (CYP11B2), and 6.3 × 104 (MC2R) times higher than nonsteroidogenic fibroblast control. This correlated with urine steroid metabolome profiling showing 2 fivefold increases in the excretion of the metabolites of 11-deoxycortisol, 21-deoxycortisol, and total glucocorticoids. Leydig-specific genes were 4.3 × 101 (LHCGR) and 9.3 × 100 (HSD17B3) times higher than control, and urinary steroid profiling showed twofold increased excretion of the major androgen metabolites androsterone and etiocholanolone. These distinctly increased steroid metabolites were suppressed by dexamethasone but unresponsive to human chorionic gonadotropin stimulation, supporting the role of ACTH, but not luteinizing hormone, in regulating tumor-specific steroid excess.

Conclusion:
We report bilateral testicular tumors occurring in a patient with recurrent Cushing disease 12 years after bilateral adrenalectomy. Using mRNA expression analysis and steroid metabolome profiling, the tumors demonstrated both adrenocortical and gonadal steroidogenic properties, similar to testicular adrenal rest tumors found in patients with congenital adrenal hyperplasia, suggesting the presence of pluripotent cells even in patients without congenital adrenal hyperplasia.
11-Oxygenated C19 Steroids Are the Predominant Androgens in Polycystic Ovary Syndrome
Authors: O’Reilly Michael W. , Kempegowda Punith , Jenkinson Carl , Taylor Angela E. , Quanson Jonathan L. , Storbeck Karl-Heinz , Arlt Wiebke 
Published: November 2016

Abstract

Context:
Androgen excess is a defining feature of polycystic ovary syndrome (PCOS), but the exact origin of hyperandrogenemia remains a matter of debate. Recent studies have highlighted the importance of the 11-oxygenated C19 steroid pathway to androgen metabolism in humans. In this study, we analyzed the contribution of 11-oxygenated androgens to androgen excess in women with PCOS.

Methods:
One hundred fourteen women with PCOS and 49 healthy control subjects underwent measurement of serum androgens by liquid chromatography-tandem mass spectrometry. Twenty-four–hour urinary androgen excretion was analyzed by gas chromatography-mass spectrometry. Fasting plasma insulin and glucose were measured for homeostatic model assessment of insulin resistance. Baseline demographic data, including body mass index, were recorded.

Results:
As expected, serum concentrations of the classic androgens testosterone (P &lt; 0.001), androstenedione (P &lt; 0.001), and dehydroepiandrosterone (P &lt; 0.01) were significantly increased in PCOS. Mirroring this, serum 11-oxygenated androgens 11β-hydroxyandrostenedione, 11-ketoandrostenedione, 11β-hydroxytestosterone, and 11-ketotestosterone were significantly higher in PCOS than in control subjects, as was the urinary 11-oxygenated androgen metabolite 11β-hydroxyandrosterone. The proportionate contribution of 11-oxygenated to total serum androgens was significantly higher in patients with PCOS compared with control subjects [53.0% (interquartile range, 48.7 to 60.3) vs 44.0% (interquartile range, 32.9 to 54.9); P &lt; 0.0001]. Obese (n = 51) and nonobese (n = 63) patients with PCOS had significantly increased 11-oxygenated androgens. Serum 11β-hydroxyandrostenedione and 11-ketoandrostenedione correlated significantly with markers of insulin resistance.

Conclusions:
We show that 11-oxygenated androgens represent the majority of circulating androgens in women with PCOS, with close correlation to markers of metabolic risk.
Bristles reduce the force required to ‘fling’ wings apart in the smallest insects
Authors: Jones Shannon K. , Yun Young J. J. , Hedrick Tyson L. , Griffith Boyce E. , Miller Laura A. 
Published: November 2016

ABSTRACTThe smallest flying insects commonly possess wings with long bristles. Little quantitative information is available on the morphology of these bristles, and their functional importance remains a mystery. In this study, we (1) collected morphological data on the bristles of 23 species of Mymaridae by analyzing high-resolution photographs and (2) used the immersed boundary method to determine via numerical simulation whether bristled wings reduced the force required to fling the wings apart while still maintaining lift. The effects of Reynolds number, angle of attack, bristle spacing and wing–wing interactions were investigated. In the morphological study, we found that as the body length of Mymaridae decreases, the diameter and gap between bristles decreases and the percentage of the wing area covered by bristles increases. In the numerical study, we found that a bristled wing experiences less force than a solid wing. The decrease in force with increasing gap to diameter ratio is greater at higher angles of attack than at lower angles of attack, suggesting that bristled wings may act more like solid wings at lower angles of attack than they do at higher angles of attack. In wing–wing interactions, bristled wings significantly decrease the drag required to fling two wings apart compared with solid wings, especially at lower Reynolds numbers. These results support the idea that bristles may offer an aerodynamic benefit during clap and fling in tiny insects.
Do psychosocial interventions have an impact on maternal perception of perinatal depression?
Authors: Firth Amanda , Haith-Cooper Melanie , Egan Dominic 
Published: November 2016

Background:Poor perinatal mental health, in particular depression, affects at least 10% of new mothers in the UK. Current best practice recommends the use of talking therapies or medication; however, many women choose not to use medication or are deterred from accessing NHS services. Those who can access NHS treatment often face a long waiting list to see a clinician or therapist. Untreated perinatal depression has an impact on the health and wellbeing of women and babies, so it is essential to consider alternative psychosocial interventions delivered by non-clinicians.Aims:This review aims to explore the effects of psychosocial interventions on maternal perception of perinatal depression.Methods:A systematic review was conducted on seven quantitative studies examining the effect of psychosocial interventions in reducing maternal symptoms of depression. Interventions focused either on physical activity or peer support, measuring depression scores with a validated screening tool.Findings:The seven reviewed studies considered either physical activity or peer support-based interventions. There is some evidence that antenatal group peer support may benefit women in the antenatal period and that postnatal peer telephone support may be helpful for primiparous women.Conclusions:Further large-scale research is required to ascertain the effectiveness of a range of interventions in improving maternal perception of perinatal depression.
A ‘cycle of care’: a model of community and hospital HIV/AIDS services
Authors: Lempp Heidi , deBoard Louise , Brown Joanna 
Published: November 2016

Care study Clare, a 25-year-old married woman, had come from Uganda with her husband in 1986. They were both political refugees. In 1987, while Clare was an inpatient and pregnant with her first child, she was tested (with informed consent and counselling) for HIV antibodies and was found to be positive. Her husband David was confirmed to be HIV antibody negative and so was their child, although this was not established conclusively until 18 months later. After discharge Clare was followed up in the HIV outpatient clinic of the Communicable Diseases Unit every 4 weeks, but was unable to attend regularly. She said she did not like attending the clinic because she was worried that other clients would learn about her diagnosis. For this reason she refused any community contact with the community liaison nurses of the HIV/AIDS team and also declined any support from the voluntary and statutory services.
Using the Myers Briggs Type Indicator — part of the solution
Authors: Allen Judy 
Published: November 2016

The Myers Briggs Type Indicator, which is based on the work of Jung, is used in an infinite variety of settings to enhance learning, personal development and team building. This article describes its particular relevance to the nursing profession. (N.B. Isabel Myers used the name Isabel Briggs Myers for publication purposes. The Indicator is termed Myers Briggs in order to indicate the involvement of her mother in its development.)