bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between residual depressive symptoms, cognition, and functioning in patients with euthymic bipolar disorder: results from the FACE-BD cohort
Authors: Roux Paul , Raust Aurélie , Cannavo Anne-Sophie , Aubin Valérie , Aouizerate Bruno , Azorin Jean-Michel , Bellivier Frank , Belzeaux Raoul , Bougerol Thierry , Cussac Iréna , Courtet Philippe , Etain Bruno , Gard Sébastien , Job Sophie , Kahn Jean-Pierre , Leboyer Marion , Olié Emilie ,   the Fonda Mental Advanced Centers of Expertise in Bipolar Disorders (FACE-BD) Collaborators, Henry Chantal , Passerieux Christine 
Published: October 2017

BackgroundThe relationship between residual depressive symptoms, cognition and functioning in patients with euthymic bipolar disorder is a subject of debate.AimsTo assess whether cognition mediates the association between residual depressive symptoms and functioning in patients with bipolar disorder who were euthymic.MethodWe included 241 adults with euthymic bipolar disorder in a multicentre cross-sectional study. We used a battery of tests to assess six cognition domains. A path analysis was then used to perform a mediation analysis of the relationship between residual depressive symptoms, cognitive components and functioning.ResultsOnly verbal and working memory were significantly associated with better functioning. Residual depressive symptoms were associated with poorer functioning. No significant relationship was found between residual depressive symptoms and any cognitive component.ConclusionsCognition and residual depressive symptoms appear to be two independent sources of variation in the functioning of people with euthymic bipolar disorder.
Surgical placement of rectus sheath catheters in a cadaveric cystectomy model
Authors: Chedgy ECP , Lowe G , Tang R , Krebs C , Sawka A , Vaghadia H , Gleave ME , SO AI 
Published: October 2017

Introduction Surgically inserted rectus sheath catheters (RSCs) are used increasingly for analgesia after cystectomy and other abdominal surgery. Currently, there is little information on the optimal positioning of RSCs to allow maximal spread of local anaesthetic. This study sought to assess the spread of dye injected via RSCs and to highlight the extent of its coverage in a fresh unembalmed cadaveric cystectomy model in order to confirm the nerve endings that are likely to be anaesthetised with RSCs. Methods Four cadavers underwent lower midline incision with limited bladder mobilisation. A RSC was inserted into the eight hemiabdomens. The RSCs were positioned either anterior (n=5) or posterior to the rectus muscle (n=3). Dye was injected down the RSCs to evaluate spread. The eight hemiabdomens were dissected anatomically to determine the surface area of dye spread and nerve root involvement. Results The mean surface area of dye spread with anteriorly placed RSCs was 30.6cm2 anterior and 25.9cm2 posterior to the rectus muscle. The mean surface area of dye spread with posteriorly placed RSCs was 11.3cm2 anterior and 37.3cm2 posterior to the rectus muscle. The mean number of nerve roots stained with anteriorly and posteriorly placed RSCs was 3.8 and 2.7 respectively. Subcutaneous spread of dye was seen with one anterior RSC insertion. Peritoneal spread was seen with one anteriorly positioned RSC. Conclusions This study has demonstrated efficient nerve root infiltration with anteriorly and posteriorly positioned RSCs. It appears that dye spreads between the fibres of the rectus muscle rather than out laterally to the nerve roots when spreading from its initial compartment.
Crossing the bridge to VATS lobectomy
Authors: Tcherveniakov P , Bogdan C , Chaudhuri N 
Published: October 2017

Introduction The impact of the introduction of video assisted thoracoscopic surgery (VATS) on the management of lung cancer 20 years ago has been well documented. However, the uptake of VATS lobectomy in surgical practice worldwide has been slower than expected. We believe that this is partly due to a lack of consensus on how this procedure should be integrated into training programmes. We present our initial experience with a newly developed training model, which could help bridge the divide between open and VATS lobectomy. Methods Two surgical registrars were initiated into this model, supervised by a single consultant. All cases were performed using a standardised three-port anterior approach with systematic lymph node dissection. Both registrars were scrubbed for each case, alternating as first surgeon and assistant, with the supervising consultant operating the camera. Results Over a 6-month period, 22 lung resections for non-small cell lung carcinoma were performed as VATS lobectomies. Thirteen of them were upper lobectomies. There were no emergency conversions to open surgery. The mean operative time for the registrars was 155 minutes compared with 140 minutes for consultant-led operations (p=0.22). There was no perioperative mortality. The most common postoperative complications were atrial fibrillation (4 cases) and prolonged air leak (3 cases). Conclusions VATS lobectomy involves a team approach. Especially in upper lobectomies, the assistant surgeon plays a significant role in the operation, often helping with the dissection as well as stapling of the bronchial and vascular structures. With a team consisting of two trainees and a supervising surgeon, the teaching process becomes more intuitive and is accelerated. This should reduce the learning curve considerably and improve safety during training.
Transoral laser surgery for laryngeal carcinoma: has Steiner achieved a genuine paradigm shift in oncological surgery?
Authors: Harris AT , Tanyi A , Hart RD , Trites J , Rigby MH , Lancaster J , Nicolaides A , Taylor SM 
Published: October 2017

Transoral laser microsurgery applies to the piecemeal removal of malignant tumours of the upper aerodigestive tract using the CO2 laser under the operating microscope. This method of surgery is being increasingly popularised as a single modality treatment of choice in early laryngeal cancers (T1 and T2) and occasionally in the more advanced forms of the disease (T3 and T4), predominantly within the supraglottis. Thomas Kuhn, the American physicist turned philosopher and historian of science, coined the phrase ‘paradigm shift’ in his groundbreaking book The Structure of Scientific Revolutions. He argued that the arrival of the new and often incompatible idea forms the core of a new paradigm, the birth of an entirely new way of thinking. This article discusses whether Steiner and colleagues truly brought about a paradigm shift in oncological surgery. By rejecting the principle of en block resection and by replacing it with the belief that not only is it oncologically safe to cut through the substance of the tumour but in doing so one can actually achieve better results, Steiner was able to truly revolutionise the management of laryngeal cancer. Even though within this article the repercussions of his insight are limited to the upper aerodigestive tract oncological surgery, his willingness to question other peoples’ dogma makes his contribution truly a genuine paradigm shift.
Virtuality and enhancement in Richard McGuire’s Here(s)
Authors: Brown Kieron Michael 
Published: October 2017

Abstract
The reading process of comics involves a significant virtual component, arising from the often complex ways in which readers navigate space and time. In few instances is the depiction of space and time as radical as in Richard McGuire’s Here, which uses inset panels to jump between various points in time within a single space. The 2014 book version of Here was followed by an eBook containing specifically digital features, such as subtle animation, and the untethering of inset panels from their original host panels. These features led to the eBook being titled Here (Enhanced edition). This article challenges the use of the term ‘enhanced’ with reference to the eBook, regarding an enhancement as an increase in number rather than an improvement. Borrowing from a conception of enhancement from the field of user interface (UI) design, it is suggested that the digital version of Here cannot be considered enhanced in terms of navigation because of a lack of core functionality between platforms. Use of the term is also questionable in terms of content, as despite additional combinations of panels, the potential connections between elements in the eBook are available in the print version if the reader is prepared to make them.
La gestión del conocimiento y la sostenibilidad de la acreditación del Hospital Pablo VI Bosa de Bogotá
Authors: Cortés Quiroga Luz Jeannette 
Published: October 2017

<p>En las instituciones de salud en Colombia no se ha explorado la Gestión del Conocimiento (GC) y su articulación con el Sistema Único de Acreditación en Salud (SUA), como facilitadores efectivos en la creación de ventajas competitivas y el desarrollo de innovación. El objetivo de esta investigación es determinar la relación existente entre la GC de una entidad de salud acreditada<br />de Primer Nivel en Bogotá, y la sostenibilidad del SUA, implementando una propuesta que articule la GC y SUA en la organización. El proyecto corresponde<br />a un estudio mixto concurrente, de tipo descriptivo. Se seleccionó como base la teoría de “creación del conocimiento” (Nonaka y Takeuchi, 2000). Se aplicaron<br />técnicas cuantitativas y cualitativas de recolección de datos: revisión documental, encuestas a colaboradores (n=310) y entrevistas semiestructuradas a directivos (n=5). Para el análisis de datos cuantitativos se utilizaron medidas de frecuencia y para las entrevistas análisis de contenido, realizando posteriormente triangulación de resultados. Se realiza una propuesta metodológica de articulación del SUA y la GC en la entidad, con posterior validación a través de los equipos de mejora continua. Como conclusiones, se encuentra que el SUA tiene incorporados elementos de la teoría de Nonaka y Takeuchi que facilitan la creación, captura y transferencia del conocimiento en la entidad, y por tanto promueven el aprendizaje de los colaboradores, facilitando su sostenibilidad. La entidad objeto de estudio tiene un grado de avance en la GC de “moderado a avanzado"</p>
Intravenous Zanamivir in Hospitalized Patients With Influenza
Authors: Bradley John S. , Blumer Jeffrey L. , Romero José R. , Michaels Marian G. , Munoz Flor M. , Kimberlin David W. , Pahud Barbara , DeBiasi Roberta L. , Yamamoto Go , Roberts Grace , Hossain Mohammad , Shortino Denise , Yates Phillip J. , Adams Bryan , Peppercorn Amanda 
Published: October 2017

BACKGROUND:
Children with severe influenza infection may require parenteral therapy if oral or inhaled therapies are ineffective or cannot be administered. Results from a study investigating intravenous (IV) zanamivir for the treatment of hospitalized infants and children with influenza are presented.

METHODS:
This phase II, open-label, multicenter, single-arm study assessed the safety of investigational IV zanamivir in hospitalized children with influenza. Safety outcomes included treatment-emergent adverse events (TEAEs), clinical laboratory measurements, and vital signs. Clinical outcomes, pharmacokinetics, and virologic efficacy data were collected as key secondary outcomes.

RESULTS:
In total, 71 children received treatment with investigational IV zanamivir (exposure comparable to 600 mg twice daily in adults). TEAEs and serious TEAEs (STEAEs) were reported in 51 (72%) and 15 (21%) patients, respectively. The mortality rate was 7%, and median durations of hospital and ICU stays were 6 and 7.5 days, respectively. No STEAEs or deaths were considered related to IV zanamivir treatment, and no patterns of TEAEs, laboratory abnormalities, or vital signs were observed. The mean zanamivir exposures from 34 patients with normal renal function who received 12 mg/kg, 14 mg/kg, or 600 mg of IV zanamivir ranged from 64.5 to 110 hour·µg/mL. The median change from baseline in the viral load was −1.81 log10 copies per mL after 2 days of treatment.

CONCLUSIONS:
The safety profile of IV zanamivir was favorable, with no drug-related STEAEs reported. The majority of children experienced virologic response and clinical improvement during the treatment course. Systemic zanamivir exposures in children were consistent with adults.
Whole body vibration and blood glucose levels in elderly people: a pilot study
Authors: Licurci Maria das Graças Bastos , Fagundes Alessandra De Almeida , Arisawa Emilia Angela Lo Schiavo 
Published: October 2017

***Whole body vibration and blood glucose levels in elderly people: a pilot study***AIMS: To evaluate the effect of whole-body vibration therapy on blood glucose levels of elderly people using a vibratory platform.METHODS: The study included volunteers of both genders, aged between 60 and 75 years, without gait disorders or motor disabilities. Individuals with systemic disease, obesity, conflicting treatments, tobacco users, and those who could not understand the maneuvers were excluded. The study consisted of a single session of whole-body vibration. Heart rate, respiratory rate, arterial blood pressure, and blood glucose were obtained for each participant at baseline, immediately before the procedure. Volunteers were then placed in the standing position on the ground of an oscillating platform and treated for 10 min with a frequency of vibration set at 20 Hz (displacement ±6 mm; orbital vibration). Immediately after the whole-body vibration session, all data were collected again. Comparisons were made between baseline and post-treatment data. Normality was tested by Kolmogorov-Smirnov test. Data were analyzed using paired Student’s t-test or Wilcoxon test as appropriate. The level of significance was set at p<0.05.RESULTS: Eleven participants (seven men, four women) participated of the study. The mean age was 64.18±4.37 years. The results showed a significant decrease in the glycemic indexes (p=0.016) and an increase in the respiratory rate (p=0.047) after the whole-body vibration session.CONCLUSIONS: Healthy elderly subjected for 10 minutes to whole-body vibration set at 20 Hz presented reduction of blood glucose levels and increasing of respiratory rate.
O consumo de peixe anchoita na alimentação escolar: aceitabilidade e adesão
Authors: Fonseca Simone Guerra , Scarparo Ana Luiza Sander , Capalonga Roberta , De Oliveira Luciana Dias , Madureira Lauro Saint Pastous , Da Silva Vanuska Lima 
Published: October 2017

Objetivo: Avaliar a possibilidade de inclusão do peixe Engraulis anchoita na alimentação escolar, considerando a aceitabilidade e a adesão, e os fatores que interferem em seu consumo pelos estudantes de escolas públicas no Rio Grande do Sul (RS).Materiais e Métodos: Trata-se de um estudo transversal realizado em escolas públicas do Rio Grande do Sul, Brasil, que compreendeu duas etapas: a primeira analisando a aceitabilidade, pelo método Escala Hedônica, e adesão à preparação “massa com molho de anchoita”; a segunda avaliando a adesão em diferentes preparações com o peixe. Foi avaliada a frequência, absoluta e relativa, utilizando o Programa SPSS 18.0, onde se obteve os valores percentuais e médias de aceitabilidade e adesão dos itens em estudo. O projeto foi aprovado pelo Comitê de Ética em Pesquisa da Universidade Federal do Rio Grande do Sul sob nº 21550, atendendo a todos os critérios legais previstos para pesquisa científica com humanos.Resultados: 1ª etapa, aceitabilidade: participaram 26.533 escolares, sendo 10.169 de escolas estaduais, 6.278 de Rio Grande e 10.086 de Porto Alegre. 2ª etapa, adesão: participaram 25.778 alunos de 77 escolas estaduais e 22 de Porto Alegre. Na etapa 1, verificou-se que 68, 71 e 81% dos alunos, respectivamente, do Estado, Rio Grande e Porto Alegre gostaram da preparação. A adesão foi de 64% nas escolas estaduais e de 62% nas de Rio Grande, enquanto que nas de Porto Alegre foi de 45%. Na etapa 2, a média de adesão foi de 92,1% para pizza, 72,3% para polenta, 87,5% para batata, 83,9% para pão, 72,9% para risoto e 68,5% para massa.Conclusão: Acredita-se ser possível a inclusão do Engraulis anchoita na alimentação escolar por meio de iniciativas que promovam o consumo de pescado.
On the role of enterococci in the bloodstream: Results of a single-center, retrospective, observational study at a German University Hospital
Authors: Frickmann Hagen , Köller Kerstin , Veil Irina , Weise Mirjam , Ludyga Alicja , Schwarz Norbert Georg , Warnke Philipp , Podbielski Andreas 
Published: October 2017

This study assesses the clinical relevance of vancomycin-susceptible enterococci in bacteremic patients and compares it with bacteremia due to Staphylococcus aureus and Escherichia coli.
During a 5-year-study interval, clinical and diagnostic features of patients with enterococcal bacteremia were compared to those of patients with E. coli or S. aureus bacteremia. Each patient was only counted once per hospital stay.
During the 5-year study interval, data from 267 patients with enterococcal bacteremia and from 661 patients with bacteremia due to E. coli or S. aureus were evaluated. In spite of a comparable risk of death, patients with enterococci more frequently needed catecholamines and invasive ventilation. Furthermore, enterococci were more frequently associated with a mixed bacterial flora in bloodstream infections. While fatal sepsis due to E. coli and S. aureus was associated with typical shock symptoms, this association was not confirmed for enterococci.
Although enterococcal bacteremia is associated with a risk of dying comparable to that with bacteremia due to E. coli and S. aureus, a lower pathogenic potential of enterococci in bloodstream has to be acknowledged. Enterococci in the bloodstream are more likely to be an epiphenomenon of impending death than its major cause.
Exploring the Significance of Mecca Sacred Mosque Global Location
Authors: Wazeri Yehia Hassan 
Published: October 2017

<span lang="EN-US">In traditional Islamic cities, the great mosque lies in the middle as the main landmark of the city. It is stated in the Qur'an that the Ka’ba (Mecca sacred mosque) was the first house that was built in Mecca city for humanity to worship Allah. Therefore, Mecca is the holiest city of Islam, and the goal of the annual Muslim hajj (pilgrimage). The objective of the present study is to explore the significance of sacred mosque of Mecca global location on dry land by using accurate measurements and Satellite programs.</span><span lang="EN-US">The results of the study illustrate that the sacred mosque of<span> </span>Mecca equally distances away from the following locations:</span><span>1) </span><span lang="EN-US">The farthest borders edges of Africa and Europe as well,</span><span> 2) </span><span lang="EN-US">The nearest borders of the new world continents along with a part of Asia which meeting the Northern borders of North America at the Bering Sea,</span><span> 3) </span><span lang="EN-US">The farthest borders of the new world continents that represent the outer edges of the dry land</span><span>, 4) </span><span lang="EN-US">Finally, the Ka’ba is equally distant from the geographical centers of the new world continents.</span>
Twitter-Based Detection of Illegal Online Sale of Prescription Opioid
Authors: Mackey Tim K. , Kalyanam Janani , Katsuki Takeo , Lanckriet Gert 
Published: October 2017

Objectives. To deploy a methodology accurately identifying tweets marketing the illegal online sale of controlled substances. Methods. We first collected tweets from the Twitter public application program interface stream filtered for prescription opioid keywords. We then used unsupervised machine learning (specifically, topic modeling) to identify topics associated with illegal online marketing and sales. Finally, we conducted Web forensic analyses to characterize different types of online vendors. We analyzed 619 937 tweets containing the keywords codeine, Percocet, fentanyl, Vicodin, Oxycontin, oxycodone, and hydrocodone over a 5-month period from June to November 2015. Results. A total of 1778 tweets (< 1%) were identified as marketing the sale of controlled substances online; 90% had imbedded hyperlinks, but only 46 were “live” at the time of the evaluation. Seven distinct URLs linked to Web sites marketing or illegally selling controlled substances online. Conclusions. Our methodology can identify illegal online sale of prescription opioids from large volumes of tweets. Our results indicate that controlled substances are trafficked online via different strategies and vendors. Public Health Implications. Our methodology can be used to identify illegal online sellers in criminal violation of the Ryan Haight Online Pharmacy Consumer Protection Act.
Integrating HIV Preexposure Prophylaxis (PrEP) Into Routine Preventive Health Care to Avoid Exacerbating Disparities
Authors: Calabrese Sarah K. , Krakower Douglas S. , Mayer Kenneth H. 
Published: October 2017

More than 3 decades since its emergence in the United States, HIV continues to spread and disproportionately affect socially marginalized groups. Preexposure prophylaxis (PrEP), a highly effective prevention strategy federally approved since 2012, could fundamentally alter the course of the epidemic. However, PrEP’s potential has not been fully realized, in part because health care providers have been slow to adopt PrEP in clinical practice and have been selective in their discussion of PrEP with patients. This nonstandardized approach has constrained PrEP access. PrEP access has not only been inadequate but also inequitable, with several groups in high need showing lower rates of uptake than do their socially privileged counterparts. Recognizing these early warning signs that current approaches to PrEP implementation could exacerbate existing HIV disparities, we call on health professionals to integrate PrEP into routine preventive health care for adult patients—particularly in primary care, reproductive health, and behavioral health settings. Drawing on the empirical literature, we present 4 arguments for why doing so would improve access and access equity, and we conclude that the benefits clearly outweigh the challenges.
A 21st-Century Public Health Approach to Abortion
Authors: Roberts Sarah C. M. , Fuentes Liza , Berglas Nancy F. , Dennis Amanda J. 
Published: October 2017

In the United States, groups advocating for and against abortion rights often deploy public health arguments to advance their positions. Recently, these arguments have evolved into state laws that use the government health department infrastructure to increase law enforcement and regulatory activities around abortion. Many major medical and public health associations oppose these new laws because they are not evidence-based and do not protect women’s health. Yet state health departments have been defending these laws in court. We propose a 21st-century public health approach to abortion based in an accepted public health framework. Specifically, we apply the Centers for Disease Control and Prevention’s 10 Essential Public Health Services framework to abortion to describe how health departments should engage with abortion. With this public health framework as our guide, we argue that health departments should be facilitating women’s ability to obtain an abortion in the state and county where they reside, researching barriers to abortion care in their states and counties, and promoting the use of a scientific evidence base in abortion-related laws, policies, regulations, and implementation of essential services.