bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in Pain Sensitization After Bariatric Surgery
Authors: Stefanik Joshua J. , Felson David T. , Apovian Caroline M. , Niu Jingbo , Margaret Clancy M. , LaValley Michael P. , Neogi Tuhina 
Published: January 2018

ObjectiveTo evaluate changes in pain (at the knee and elsewhere) and pain sensitization in obese subjects with knee pain who were having bariatric surgery compared with similarly obese individuals who were undergoing medical management.MethodsThis study included a cohort of subjects who were having bariatric surgery and those undergoing medical management. Knee pain severity of the more painful knee (index knee) was assessed at baseline and at 12 months using the Western Ontario and McMaster Universities Osteoarthritis Index. The pressure pain threshold (PPT) was evaluated at the index patella and the right wrist. Low patella PPT may reflect peripheral and/or central sensitization, and low wrist PPT may reflect central sensitization. The mean change in measures of pain and pain sensitization was analyzed in the surgery and medical management groups separately.ResultsA total of 45 subjects in the surgery group and 22 in the medical management group completed baseline and follow‐up visits. The mean weight loss was 32.7 kg (29.0%) and 4.6 kg (4.1%) in the surgery and medical management groups, respectively. Knee pain decreased only in the surgery group, in which the PPT at the patella improved by 38.5% (P = 0.0007) and at the wrist by 30.9% (P = 0.005). There was no significant change in PPT in the medical management group.ConclusionPersons who underwent bariatric surgery experienced an improvement in pain sensitization, reflected by improvements in PPT. This improvement was observed not only at the patella, but also at the wrist, suggesting that central sensitization improved after bariatric surgery.
Dopamine: Just the Right Medicine for Membranes
Authors: Yang Hao‐Cheng , Waldman Ruben Z. , Wu Ming‐Bang , Hou Jingwei , Chen Lin , Darling Seth B. , Xu Zhi‐Kang 
Published: January 2018

AbstractMussel‐inspired chemistry has attracted widespread interest in membrane science and technology. Demonstrating the rapid growth of this field over the past several years, substantial progress has been achieved in both mussel‐inspired chemistry and membrane surface engineering based on mussel‐inspired coatings. At this stage, it is valuable to summarize the most recent and distinctive developments, as well as to frame the challenges and opportunities remaining in this field. In this review, recent advances in rapid and controllable deposition of mussel‐inspired coatings, dopamine‐assisted codeposition technology, and photoinitiated grafting directly on mussel‐inspired coatings are presented. Some of these technologies have not yet been employed directly in membrane science. Beyond discussing advances in conventional membrane processes, emerging applications of mussel‐inspired coatings in membranes are discussed, including as a skin layer in nanofiltration, interlayer in metal‐organic framework based membranes, hydrophilic layer in Janus membranes, and protective layer in catalytic membranes. Finally, some critical unsolved challenges are raised in this field and some potential pathways are proposed to address them.
Novel Quercetin Aggregation‐Induced Emission Luminogen (AIEgen) with Excited‐State Intramolecular Proton Transfer for In Vivo Bioimaging
Authors: He Ting , Niu Na , Chen Zhijun , Li Shujun , Liu Shouxin , Li Jian 
Published: January 2018

AbstractAggregation‐induced emission luminogens (AIEgens) that undergo excited‐state intramolecular proton transfer (ESIPT) have many applications in bioimaging since they have high quantum efficiency in the aggregated state and a low background signal in aqueous solutions because of their large Stokes shift. One disadvantage of many of the AIEgens with ESIPT that has been described so far is that they require time‐consuming synthesis and the use of toxic reagents. Another disadvantage with most of these materials is that they are only used for bioimaging in cells and are unsuitable for in vivo bioimaging. Herein, a new AIEgen with ESIPT, quercetin (QC) is described, which is easily prepared from Sophora japonica. AIE is attributed to crystallization‐promoted keto emission. The fluorescence is temperature dependent and shows strong resistance to photobleaching. QC AIEgen with ESIPT is shown to have excellent biocompatibility and is successfully used for bioimaging both in cellular cytoplasm and in vivo.
Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine
Authors: Foyt Daniel A. , Norman Michael D. A. , Yu Tracy T. L. , Gentleman Eileen 
Published: January 2018

AbstractRegenerative medicine aims to tackle a panoply of challenges from repairing focal damage to articular cartilage to preventing pathological tissue remodeling after myocardial infarction. Hydrogels are water‐swollen networks formed from synthetic or naturally derived polymers and are emerging as important tools to address these challenges. Recent advances in hydrogel chemistries are enabling researchers to create hydrogels that can act as 3D ex vivo tissue models, allowing them to explore fundamental questions in cell biology by replicating tissues' dynamic and nonlinear physical properties. Enabled by cutting edge techniques such as 3D bioprinting, cell‐laden hydrogels are also being developed with highly controlled tissue‐specific architectures, vasculature, and biological functions that together can direct tissue repair. Moreover, advanced in situ forming and acellular hydrogels are increasingly finding use as delivery vehicles for bioactive compounds and in mediating host cell response. Here, advances in the design and fabrication of hydrogels for regenerative medicine are reviewed. It is also addressed how controlled chemistries are allowing for precise engineering of spatial and time‐dependent properties in hydrogels with a look to how these materials will eventually translate to clinical applications.
Water‐Mediated One‐pot Three‐Component Synthesis of Hydrazinyl‐Thiazoles Catalyzed by Copper Oxide Nanoparticles Dispersed on Titanium Dioxide Support: A Green Catalytic Process
Authors: Reddy G. Trivikram , Kumar G. , Reddy N. C. Gangi 
Published: January 2018

AbstractThe present work describes the catalytic activity of copper oxide nanoparticles dispersed on titanium dioxide in water for one‐pot synthesis of a library of hydrazinyl‐thiazoles via a three‐component reaction of various aldehydes/ketones with thiosemicarbazide and different phenacyl bromides. The structure of the synthesized compound, (E)‐4‐(4‐bromophenyl)‐2‐(2‐(4‐methoxybenzylidene) hydrazinyl)thiazole is confirmed by single crystal X‐ray diffraction studies. The catalyst prepared by a molten‐salt method is characterized by X‐ray diffraction, field emission scanning electron microscopy, transmission electron microscopy, energy dispersive X‐ray spectroscopy, X‐ray photoelectron spectroscopy, Auger electron spectroscopy and electron spin resonance spectroscopy. The noteworthy advantages of this method include its broad substrate scope, clean reaction profile, short reaction times and high yields at low catalyst loading. Further, the product does not require any chromatographic purification and the method has the potential for large‐scale applications in pharmaceutical industries. In addition, the developed catalyst can be recovered and reused for 5 times without significant loss of activity. Mechanistic studies suggest that the reaction begins with the activation of the carbonyl group of both aldehyde/ketone and phenacyl bromide by copper oxide nanoparticles supported on titanium dioxide in water. These studies reveal that the reaction proceeds via the formation of thiosemicarbazone intermediate.magnified image
An Efficient and Practical Method for the Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols
Authors: Borrego Lorenzo G. , Recio Rocío , Alcarranza Manuel , Khiar Noureddine , Fernández Inmaculada 
Published: January 2018

AbstractAn efficient sulfinamide/olefin based chiral ligand, MetSulfolefin, has been developed for the enantioselective rhodium‐catalysed addition of aryl‐boronic acids to trifluoromethyl ketones. This shelf‐stable ligand is insensitive to air, oxygen and moisture, and it is obtained in only two high yielding steps from cheap commercially available (R)‐tert‐butanesulfinamide. The new ligand tolerates the use of hindered boronic acids and leads to the formation of a series of chiral trifluoromethyl‐substituted tertiary carbinols in high yields and excellent enantioselectivities (up to >99% ee).magnified image
Rhodium(III)‐Catalyzed Selective Direct Olefination of Imidazoles
Authors: Zhao Haoqiang , Xu Jianbin , Chen Changjun , Xu Xin , Pan Yixiao , Zhang Zongyao , Li Huanrong , Xu Lijin 
Published: January 2018

AbstractRhodium(III)‐catalyzed chelation‐assisted highly regio‐ and stereoselective direct olefination of imidazoles with olefins has been developed. A broad range of C2‐substituted N‐(2‐pyrimidyl)imidazoles underwent smooth C5‐olefination with both activated and unactivated olefins to furnish the corresponding products in good to excellent yields with high tolerance of functional groups on both coupling partners in the presence of a cationic rhodium(III) catalyst. The combination of a catalytic amount of Cu(OAc)2 (copper(II) acetate) and O2 (oxygen) serves as the terminal oxidant. This protocol strongly relies on the use of 2‐substituted imidazoles as the substrates, and the presence of readily installable and removable pyrimidyl directing group was found to be critical for catalysis. Mechanistic studies suggest the involvement of a five‐membered rhodacycle as the key intermediate in the catalytic cycle. The method can also be extended to the coupling reaction of benzimidazoles with olefins.magnified image
Nonvolatile Electric‐Optical Memory Controlled by Conductive Filaments in Ti‐Doped BiFeO3
Authors: Lu Zengxing , Yang Xiaodong , Jin Chen , Li Peilian , Wan Jian‐guo , Liu Jun‐ming 
Published: January 2018

AbstractIn ferroelectric films, the resistance switching (RS) and ferroelectric photovoltaic effects are ideal for developing next‐generation electronic devices, especially memory devices. In this work, a feasible electric‐optical memory prototype based on both effects is proposed, which can operate with electric writing and optical reading, and realized in Ti‐doped BiFeO3 films. The RS behavior and the photovoltaic effect at different stage of RS are measured carefully. The results show that the films exhibit filament‐type RS effect. Furthermore, the photovoltaic open‐circuit voltage is demonstrated to be well controlled by switching the resistance state, and such a manipulation can be repeated reliably. By carrying out first‐principles calculations, the working mechanism of the devices is further analyzed, which reveals that the doping of Ti plays a crucial role in the occurrence of the filament‐type RS effect and the improvement of photovoltaic effect. This work provides a feasible avenue to develop high‐performance and low‐power‐consumption memory devices.
Design of CMOS Compatible, High‐Speed, Highly‐Stable Complementary Switching with Multilevel Operation in 3D Vertically Stacked Novel HfO2/Al2O3/TiOx (HAT) RRAM
Authors: Banerjee Writam , Zhang Xumeng , Luo Qing , Lv Hangbing , Liu Qi , Long Shibing , Liu Ming 
Published: January 2018

AbstractComplementary resistive switching (CRS) is a suitable approach to minimize the sneak leakage paths through a large resistive random access memory (RRAM) array. Here, an effective CRS design with a HfO2/Al2O3/TiOx (HAT) trilayer structure integrated in a 3D vertically stacked RRAM array is reported. The design shows voltage‐controlled resistive switching and CRS performance with multilevel operations. High‐speed switching is observed with the HAT design. The device shows SET and the RESET transitions with speeds of −3.5 V@30 ns and +3.8 V@150 ns, respectively. As well as with the DC measurements, the CRS switching is achieved under AC switching dynamics measurement. Maintaining the same applied pulse polarity, the lower amplitude can switch the device to the SET and the higher amplitude can switch it to the RESET. A highly nonlinear (nonlinearity >102) CRS is obtained at a high temperature of 150 °C. In the HAT devices, the origin of CRS is due to the anionic redistribution in HfO2 and TiOx layers, leaving Al2O3 as tunnel barrier. The achievements reported here indicate the applicability of the HAT design for future high‐speed high‐density applications.
Risk assessment for metalworking fluids and cancer outcomes
Authors: Park Robert M. 
Published: January 2018

BackgroundMetalworking fluids (MWF) are complex mixtures with dermal and inhalation exposure. Published reports reveal excess cancer risk.MethodsUsing published findings exposure response was derived for each attributable cancer site. Aggregate excess lifetime risk was estimated by applying a lifetable calculation.ResultsCancer sites contributing the most attributable cases were larynx, esophagus, brain, female breast, and uterine cervix. With constant workplace MWF exposure of 0.1 mg/m3 over a 45 years working life, the risk of attributable cancer was 3.7% or, excluding the less certain female cancers, 3.1%.ConclusionSubstantial cancer risks occurred at 0.1 mg/m3 MWF, one fourth of the current NIOSH recommended exposure limit for MWF total particulate. Because ingredients in current MWF remain from earlier formulations, it is likely that some MWF carcinogenicity persists today. Although important changes have occurred, newer agents are being continually introduced with little or no knowledge of chronic health risks.
The black legend on the Spanish presence in the low countries: Verifying shared beliefs on genetic ancestry
Authors: Larmuseau Maarten H.D. , Calafell Francesc , Princen Sarah A. , Decorte Ronny , Soen Violet 
Published: January 2018

AbstractObjectivesWar atrocities committed by the Spanish army in the Low Countries during the 16th century are so ingrained in the collective memory of Belgian and Dutch societies that they generally assume a signature of this history to be present in their genetic ancestry. Historians claim this assumption is a consequence of the so‐called “Black Legend” and negative propaganda portraying and remembering Spanish soldiers as extreme sexual aggressors. The impact of the presence of Spaniards during the Dutch Revolt on the genetic variation in the Low Countries has been verified in this study.Materials and methodsA recent population genetic analysis of Iberian‐associated Y‐chromosomal variation among Europe is enlarged with representative samples of Dutch (N = 250) and Flemish (N = 1,087) males. Frequencies of these variants are also compared between donors whose oldest reported paternal ancestors lived in—nowadays Flemish—cities affected by so‐called Spanish Furies (N = 116) versus other patrilineages in current Flemish territory (N = 971).ResultsThe frequencies of Y‐chromosomal markers Z195 and SRY2627 decline steeply going north from Spain and the data for the Flemish and Dutch populations fits within this pattern. No trend of higher frequencies of these variants has been found within the well‐ascertained samples associated with Spanish Fury cities.DiscussionAlthough sexual aggression did occur in the 16th century, these activities did not leave a traceable “Spanish” genetic signature in the autochthonous genome of the Low Countries. Our results support the view that the ‘Black Legend’ and historical propaganda on sexual aggression have nurtured today's incorrect assumptions regarding genetic ancestry.
Configurational Isomerism in Polyoxovanadates
Authors: Mahnke Lisa K. , Kondinski Aleksandar , Warzok Ulrike , Näther Christian , van Leusen Jan , Schalley Christoph A. , Monakhov Kirill Yu. , Kögerler Paul , Bensch Wolfgang 
Published: January 2018

AbstractA water‐soluble derivative of the polyoxovanadate {V15E6O42} (E=semimetal) archetype enables the study of cluster shell rearrangements driven by supramolecular interactions. A reaction unique to E=Sb, induced exclusively by ligand metathesis in peripheral [Ni(ethylenediamine)3]2+ counterions, results in the formation of the metastable α1* configurational isomer of the {V14Sb8O42} cluster type. Contrary to all other polyoxovanadate shell architectures, this isomer comprises an inward‐oriented vanadyl group and is ca. 50 and 12 kJ mol−1 higher in energy than the previously isolated α and β isomers, respectively. We discuss this unexpected reaction in light of supramolecular Sb−O⋅⋅⋅V and Sb−O⋅⋅⋅Sb contacts manifested in {V14Sb8O42}2 dimers detected in the solid state. ESI MS experiments confirm the stability of these dimers also in solution and in the gas phase. DFT calculations indicate that other, as of yet elusive isomers of {V14Sb8}, might be accessible as well.
Implant Insertion into an Augmented Bone Region Using the Canine Mandible Augmented by the “Casing Method”
Authors: Ono Wataru , Maruyama Kiichi , Ogiso Makoto , Mineno Seiji , Izumi Yuichi 
Published: January 2018

ABSTRACTThe purpose of this study was to examine the efficacy of bone augmentation using the “Casing Method,” which enables large‐scale osteogenesis, and the feasibility of using the augmented bone in dental implants. Three Beagle dogs were used. After tooth extraction, a polyethylene terephthalate case (20 mm × 5 mm × 10 mm) was placed on the buccal surface of the mandible. A mixture of hydroxyapatite and beta‐tricalcium phosphate (volume ratio = 1:1) was infiltrated into a suspension of autologous superfine bone powder and plasma, and the resulting mixture was packed into the case. After 16 weeks, the implant was inserted into the augmented bone and the original bone. Specimens of the mandible were collected at 2, 4, 8, and 16 weeks after implant insertion, and undecalcified sections were prepared. The integration of the implant into the surrounding bone tissue was observed histologically. Favorable bone formation was observed in the regions where bone augmentation was performed. The space between the cut bone surface and the implant was filled with newly formed bone in both the augmented and original bone regions. In addition, there was higher bone density in the augmented bone than that in the original bone at the coronal half of the implant at 16 weeks. As a result, bone‐to‐implant contact was significantly higher in the augmented bone region than in the original bone region. These results suggest that bone augmentation surgery using the “Casing Method” is an effective technique for expanding the application of dental implants. Anat Rec, 301:892–901, 2018. © 2018 Wiley Periodicals, Inc.
Switched Memory B Cells Are Increased in Oligoarticular and Polyarticular Juvenile Idiopathic Arthritis and Their Change Over Time Is Related to Response to Tumor Necrosis Factor Inhibitors
Authors: Marasco Emiliano , Aquilani Angela , Cascioli Simona , Moneta Gian Marco , Caiello Ivan , Farroni Chiara , Giorda Ezio , D'Oria Valentina , Marafon Denise Pires , Magni‐Manzoni Silvia , Carsetti Rita , De Benedetti Fabrizio 
Published: January 2018

ObjectiveTo investigate whether abnormalities in B cell subsets in patients with juvenile idiopathic arthritis (JIA) correlate with clinical features and response to treatment.MethodsA total of 109 patients diagnosed as having oligoarticular JIA or polyarticular JIA were enrolled in the study. B cell subsets in peripheral blood and synovial fluid were analyzed by flow cytometry.ResultsSwitched memory B cells were significantly increased in patients compared to age‐matched healthy controls (P < 0.0001). When patients were divided according to age at onset of JIA, in patients with early‐onset disease (presenting before age 6 years) the expansion in switched memory B cells was more pronounced than that in patients with late‐onset disease and persisted throughout the disease course. In longitudinal studies, during methotrexate (MTX) treatment, regardless of the presence or absence of active disease, the number of switched memory B cells increased significantly (median change from baseline 36% [interquartile range {IQR} 15, 66]). During treatment with MTX plus tumor necrosis factor inhibitors (TNFi), in patients maintaining disease remission, the increase in switched memory B cells was significantly lower than that in patients who experienced active disease (median change from baseline 4% [IQR −6, 32] versus 41% [IQR 11, 73]; P = 0.004). The yearly rate of increases in switched memory B cells was 1.5% in healthy controls, 1.2% in patients who maintained remission during treatment with MTX plus TNFi, 4.7% in patients who experienced active disease during treatment with MTX plus TNFi, and ~4% in patients treated with MTX alone.ConclusionSwitched memory B cells expand during the disease course at a faster rate in JIA patients than in healthy children. This increase is more evident in patients with early‐onset JIA. TNFi treatment inhibits this increase in patients who achieve and maintain remission, but not in those with active disease.
In situ Generated Ruthenium Catalyst Systems Bearing Diverse N‐Heterocyclic Carbene Precursors for Atom‐Economic Amide Synthesis from Alcohols and Amines
Authors: Cheng Hua , Xiong Mao‐Qian , Cheng Chuan‐Xiang , Wang Hua‐Jing , Lu Qiang , Liu Hong‐Fu , Yao Fu‐Bin , Chen Cheng , Verpoort Francis 
Published: January 2018

AbstractThe transition‐metal‐catalyzed direct synthesis of amides from alcohols and amines is herein demonstrated as a highly environmentally benign and atom‐economic process. Among various catalyst systems, in situ generated N‐heterocyclic carbene (NHC)‐based ruthenium (Ru) halide catalyst systems have been proven to be active for this transformation. However, these existing catalyst systems usually require an additional ligand to achieve satisfactory results. In this work, through extensive screening of a diverse variety of NHC precursors, we discovered an active in situ catalyst system for efficient amide synthesis without any additional ligand. Notably, this catalyst system was found to be insensitive to the electronic effects of the substrates, and various electron‐deficient substrates, which were not highly reactive with our previous catalyst systems, could be employed to afford the corresponding amides efficiently. Furthermore, mechanistic investigations were performed to provide a rationale for the high activity of the optimized catalyst system. NMR‐scale reactions indicated that the rapid formation of a Ru hydride intermediate (signal at δ=−7.8 ppm in the 1H NMR spectrum) after the addition of the alcohol substrate should be pivotal in establishing the high catalyst activity. Besides, HRMS analysis provided possible structures of the in situ generated catalyst system.
Input‐Output Decoupling of Boolean Control Networks
Authors: Pan Jinfeng , Feng Jun‐E , Yao Juan , Zhao Jianli 
Published: January 2018

AbstractThis paper is devoted to the input‐output decoupling problem of Boolean control networks (BCNs). First, a necessary and sufficient condition for the existence of comparable output subspaces is obtained as well as an algorithm to construct the comparable output subspaces. Then, two kinds of controllers are designed to solve the decoupling problem, including open‐loop controller and state feedback controller. Finally, an example is given to illustrate the effectiveness of the proposed method.