bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development And Validation of In-Vitro Release Test (IVRT) Method for Topical Complex Generic - Ganciclovir Ophthalmic Gel
Authors: Dhudashia Komal Rajendrakumar , Patel Nilesh K. 
Published: October 2024

Background:
The in-vitro release test (IVRT) is a tool to measure the amount and
the release rate of active pharmaceutical compounds released from topical semisolid dosage
forms. The IVRT provides significant information for product performance assessment and
evaluation. It is also used to assess the bioequivalence study (biowaivers) for topical semisolid
products.

Objective:
The study aims to develop and validate the IVRT method for qualitative and quantitative
estimation of ganciclovir topical products and to demonstrate the similarity between the
marketed reference product and the in-house test product of ganciclovir ophthalmic gel.

Methods:
The method was developed using a vertical diffusion cell with a synthetic cellulose
membrane, simulated tear fluid as the receiver media, and UV detection. The IVRT study was
performed at 100rpm and 32oC for 6hr. The marketed formulation containing 0.15%w/w
ganciclovir was used as a reference.

Results:
The in-house test product of ganciclovir met all characterization criteria. The analytical
method was optimized and validated with a concentration range of 2-14μg/ml and a regression
coefficient of 0.9997 as per the ICH guideline. The developed IVRT method was simple,
economical, linear, robust, reproducible, sensitive, specific, and selective to evaluate the drug
release from the formulation. The %recovery at 6hr was found to be 84.43% and 78.68% for
reference and test product of ganciclovir ophthalmic gel with correlation coefficient R2 0.9947
and 0.9921, respectively, this value justified the biowaivers between the reference and test formulation.

Conclusion:
This method can be utilized to check topical semisolid product quality, product
performance, and product uniformity. Additionally, it can also be used to waive the requirement
for bioequivalency studies for ganciclovir ophthalmic gel.
Yinxieling Inhibits Keratin 17 to Enhance Mitochondrial Function and Ameliorates Psoriasis-like Lesions
Authors: Wang Shilei , Pan Helin , Zhao Chenxi , Chen Wanqun , Zhang Jinwei 
Published: October 2024

aims:
To study investigates the mechanism of action of Yinxieling in the treatment of psoriasis.

background:
Psoriasis is a chronic skin disease characterized by erythema, scaling, and thickening. Yinxieling is a representative prescription for treating psoriasis developed by Professor Guowei Xuan, a master of traditional Chinese medicine. Keratin 17 is a key biomarker for the diagnosis and treatment of psoriasis, and its overexpression has been shown to impair mitochondrial function.

objective:
To study investigates the mechanism of action of Yinxieling in the treatment of psoriasis.

method:
In vivo, BALB/c mice were induced by imiquimod to create psoriasis-like mice model. Different doses of Yinxieling were administered to the psoriasis-like mice and PASI scores, thickness of epidermis and Keratin 17 expression of psoriasis-like mice were measured. In vitro, HaCaT cells were induced by IL-17A, IL-22 and TNF-alpha to establish psoriasis-like cells model. Yinxieling with different concentrations were administered to the psoriasis-like cells and Keratin 17 expression, adenosine triphosphate levels and oxygen consumption rates were measured. Furthermore, the psoriasis-like cells were transfected with keratin 17 plasmids. Yinxieling intervened in these psoriasis-like cells with continuous high expression of keratin 17 and adenosine triphosphate levels and oxygen consumption rates were measured.

result:
Yinxieling significantly improved PASI scores and decreased their epidermal thickness in psoriasis-like mice; Yinxieling also inhibited Krt17 expression in psoriasis-like mice and cells. Yinxieling improved ATP levels and oxygen consumption rate in psoriasis-like cells, and this effect of Yinxieling was abolished when the psoriasis-like cells were transfected with keratin 17 plasmids.

conclusion:
Yinxieling inhibits keratin 17 to enhance mitochondrial function and ameliorates psoriasis-like lesions.

other:
None
Aerosol Impact on UV Solar Irradiance and Diffuse Fraction
Authors: Codrean Andrea , Bunoiu Madalin , Paulescu Marius 
Published: October 2024

Abstract
Aerosols modify the solar irradiance levels in the ultraviolet (UV) spectral band and, as a result, influence the magnitude of the biological effects of solar radiation. Also, aerosols contribute to the changes in nature (direct/diffuse) of the UV solar radiation received by a biological organism. This work quantitatively evaluates the aerosol effects on all components of solar UV irradiance (direct-normal, diffuse and global) under clear sky conditions. A note of originality is given by the wide perspective and the depth of detail in which the influence of aerosols in the UV band is captured. In addition to the common parameters, such as aerosol nature and the atmospheric aerosol loading, fine properties of aerosols, such as absorptivity and asymmetry factor, are considered. A distinctive feature of this study is given by the analysis of the effects of aerosols on the UV diffuse fraction. In general, changes in aerosol properties substantially change the direct-normal and diffuse components of UV solar irradiance and, to a lesser extent, the global component. The diffuse fraction in the UV band decreases notably with the increase of the Ångström turbidity coefficient and the Ångström exponent. Differently, the diffuse fraction is much less sensitive to the variation of the single scattering albedo and the asymmetry factor.
An evaluation rule to manage productivity properties performance of male date palms
Authors: Abdel-Sattar Mahmoud , Al-Obeed Rashid S. , Aboukarima Abdulwahed M. , Górnik Krzysztof , El-Badan Ghada E. 
Published: October 2024

ABSTRACT
Male palm trees almost prominently display minute morphological variations; however, date palm growers rely on readily available pollen from unproven male genotypes without giving correct type selection any thought, which may result in low productivity and/or poor fruit quality. This study sought to develop an evaluation rule by calculating an evaluation index for managing the productivity characteristics performance of nine male date palms, which were examined for their pollen productivity, nutritional status and morphological traits from their leaves, pinnae and spathes. The findings showed that the evaluation rule for a male date palm should depend on pollen grains productivity and germination percentage traits with a weight of 5, spathe morphological traits with a weight of 4, pinnae morphological traits with a weight of 3, leaf morphological traits with a weight of 2 and leaf nutritional status with a weight of 1. The best productivity characteristics performance of male date palms was male No. 8 ‘M8’ due to its high evaluation index. The proposed evaluation index criterion will contribute to better information and analytical support for management of the date palm industry to maximise the effectiveness of germplasm conservation and exploitation, as well as procedural and methodological aspects of the analysis.
Die österreichische Wettbewerbsfähigkeit im Check
Authors: Sachs Andreas , Weiß Johann , Böhmer Michael 
Published: October 2024

Abstract
Austria's economy is highly competitive internationally in many areas. Nevertheless, there are various economic policy challenges. In addition, the intensity of international competition is increasing. A comparison of Austria's economic environment with 21 other highly developed economies based on comparable indicators that are available across the board shows the most important areas where action is needed. This contribution identifies the respective challenges in different areas and provides solutions. Finally, the growth effects of selected measures are quantified based on a model-based scenario calculation.
The Accuracy of Measuring Emotions, Psychophysiological Characteristics, Behavioral Parameters and Personality Traits by Video Analytics
Authors: В.А. Акимов , С.С. Диденко , В.А. Минкин 
Published: October 2024

Проведено исследование точности и погрешности различных алгоритмов измерения психофизиологических характеристик личности в зависимости от степени сжатия видео файлов и периода наблюдения испытуемого. Проанализировано 106 черно- белых видео файлов (256 градаций серого) изображений лиц испытуемых длительностью 200 секунд, формат видео 640×480, частота кадров 30 Гц. Исследование точности измерений проводилось для алгоритма искусственного интеллекта, диагностирующего COVID-19 и программы Vibraimage PRO с различными настройками быстрого преобразования виброизображения (БПВ), измеряющей поведенческие и психофизиологические параметры человека. В качестве основного критерия точности исследуемых алгоритмов была выбрана относительная погрешность измерений. Построены зависимости относительной погрешности измерений от степени сжатия видео и времени наблюдений за испытуемыми. Даны рекомендации повышения точности измерений психофизиологических и поведенческих параметров для различных характеристик обработки видео изображений лица и головы человека. Разработан новый режим БПВ названный Turbo, позволяющий снизить относительную погрешность и уменьшить время измерения психофизиологических и поведенческих параметров человека за счет увеличения мощности БПВ.
The accuracy and errors of various algorithms for measuring emotions, psychophysiological and behavioral characteristics of a person depending on the video files compression degree and the observation period was studied. The study was conducted on 106 blackand- white video files of subjects’ facial images (256 gray levels), 200 seconds duration, video format 640×480, frame rate 30 Hz. The accuracy was calculated for artificial intelligence algorithm that diagnoses COVID-19 and Vibraimage PRO program for various settings of fast vibraimage transform (FVT) measuring human emotions, behavioral and psychophysiological characteristics. The relative error of measurement was chosen as the main criterion for the accuracy of the algorithms under study. The dependences of the relative error on the degree of video compression and the period of subject observation were plotted. Recommendations are given to improve the accuracy of psychophysiological and behavioral characteristics measurements for different settings of processing video images of human face and head. New FVT Turbo mode has been developed for reducing errors and observation period for measuring emotions, psychophysiological and behavioral parameters of a person by increasing FVT power.
Differences between Conscious and Unconscious Responses to Stimuli, or Why Questionnaire Results are Always Wrong
Authors: В.А. Минкин 
Published: October 2024

Анализируется база данных тестирования 1002 испытуемых программой Профайлер+ с известной зависимостью между величинами психофизиологических реакций (ПФР) на стимулы способностей и пороков. Величина ПФР, пропорциональная значимости стимула для испытуемого измеренная в информационно-физических величинах вибрах, нормируется аналогично сознательной реакции испытуемых. Сравнительный анализ корреляции ПФР на стимулы способностей и пороков показал высокий уровень корреляции (r = 0,8) для ненормированной ПФР и низкий уровень корреляции (r = 0,24) для нормированной ПФР. Анализируются причины потери корреляции при нормировании величины ПФР. Основными причинами искажения зависимости между величинами при нормировании ПФР предложено считать персональную субъективность определения нуля и чувствительности, которая происходит при формировании сознательных ответов на вопросы опросников. Искажения исходной ПФР, связанные с искусственным формированием сознательной реакции испытуемых при ответах на вопросы опросника, приводят к необратимой потере информации о связи между исследуемыми величинами. Делается вывод о недостаточности использования сознательной реакции испытуемых при прохождении опросников для корректной оценки характеристик личности и необходимости обработки психофизиологических реакций.
The database of 1002 subjects testing by Blitz Judgment program is analyzed with the known dependence between PPR variables for the stimuli of multiple intelligences (MI) and personality vices (PV). The source PPR values proportional to the stimuli relevance for the subject, measured in information-physical quantities — vibra, are normalized similar to conscious response of the subjects. Comparative analysis of PPR correlation for MI and PV stimuli showed high level of correlation (r = 0.8) for source PPR and the low level of correlation (r = 0.24) for normalized PPR. The reasons for the loss of correlation for normalizing PPR values are analyzed. Personal subjectivity in determining PPR zero and sensitivity, occurs during formation of conscious responses to questionnaires, considered as the main reason for the distortion of the dependence between PPR variables. Distortions of source PPR associated with artificial normalization of subject’s conscious responses to questionnaires leads to irreversible loss of information about the relationship between the studied variables. Concluded that conscious responses of the subjects using questionnaires are insufficient for the correct assessment of personality traits and the processing of psychophysiological responses is required.
BRICS Expansion: New Challenges and Ways to Optimize Cooperation
Authors: Pu G. 
Published: October 2024

Today, the multipolar nature of the world is becoming more evident. As the countries gain increasing influence, BRICS members are assuming more responsibility for developing nations, transitioning from merely reacting to international financial challenges to actively shaping the global order.With the expansion of its membership, BRICS is facing new challenges and opportunities. It has become increasingly important for its member countries to critically reflect on the current international economic and political landscape and analyze their respective positions and strategies for cooperation. In the future, this alliance has the potential to establish itself as a key player in the global South, serving as a significant platform for large-scale governance.
Factors and Strategies of Russian Youth’s Protest Activity Demobilization
Authors: Parma R. V. 
Published: October 2024

In the article, protest sentiments are differentiated by the nature of constructiveness and conventionality. Destructive and unconventional protest sentiments often result in extremist and radical actions that pose a threat to the sustainable development of society. The protest youth is divided into activists, situational supporters and passive observers. The discourse analysis of modern scientific research has revealed the predominance of informational, social, political and psychological factors in the formation of protest sentiments. The researchers’ discursive proposals are compared with sociological data revealing the ideas of Russian youth about the necessary ways to develop social activity. Depending on the type of political orientation, potential strategies for the de-escalation of radical protest sentiment are determined.These strategies are based on public engagement and access to resources.
OS MEMES E O ENSINO DE LITERATURA: NOVOS MODOS DE SEDUZIR?
Authors: Subrinho Abinalio Ubiratan da Cruz , Dias de Carvalho Sousa Denise 
Published: October 2024

Este estudo trata da necessidade da inserção da e-literatura, isto é, literatura digital, no ensino básico, como estratégia de (re)aproximação do aluno-leitor que, há um certo tempo, vem se afastando das obras literárias impostas pelos programas escolares. Para tanto, interpelamos o uso dos memes literários como estratégia de sedução para alcançar o leitor, considerando que seriam capazes de fomentar novas reflexões e estudos em torno de possíveis intervenções em sala de aula. Trata-se de uma pesquisa de cunho bibliográfico, valendo-se também de instrumentos de coleta de dados oriundos da netnografia, a observação em ambientes virtuais, a seleção e a análise de arquivos digitais. Tomamos como pressupostos teóricos os estudos de Lévy (1999, 2011), Lima (2014, 2017), Martins Ivanda (2006), Martins Aracy (2013), Perrone-Moisés (2016), dentre outros. É possível com os memes literários investir numa proposta de leitura intertextual, interdiscursiva e intersemiótica, ampliando o repertório de literatura com base na exploração de objetos culturais distintos.
PENGARUH PEMBERIAN KAPSUL EKSTRAK DAUN KELOR TERHADAP PENINGKATAN KADAR HB PADA IBU HAMIL TM III DI PUSKESMAS KOTABUMI II KECAMATAN KOTABUMI SELATAN KABUPATEN LAMPUNG UTARA TAHUN 2023
Authors: Yati Erni 
Published: October 2024

Daun Kelor mengandung vitamin A, vitamin C, Vit B, kalsium, kalium, besi, dan protein, dalam jumlah sangat tinggi. Laporan data Komdat Dinas Kesehatan Kabupaten Lampung Utara tahun 2020, prevalensi anemia gizi ibu hamil di Kabupaten Lampung Utara cukup tinggi yaitu 27,6%, sedangkan di tahun 2022 mengalami peningkatan menjadi 43,7 %. Tujuan penelitian adalah untuk mengetahui Pengaruh pemberian Kapsul ekstrak daun kelor terhadap penyerapan fe untuk peningkatan kadar HB pada ibu hamil TM III di Puskesmas Kotabumi II Kecamatan Kotabumi Selatan Kabupaten Lampung Utara tahun 2023.Jenis penelitian yang digunakan adalah pre eksperimental dengan pendekatan one group pre test and post test desaign. Populasi dalam penelitian ini adalah seluruh ibu hamil TM III yang mengalami anemia di Puskesmas Kotabumi II Kecamatan Kotabumi Selatan Kabupaten Lampung Utara dengan jumlah rata-rata perbulan 30 ibu hamil. Sampel dalam penelitian ini berjumlah 17 orang. Tehnik sampling yang digunakan yaitu purposive sampling. Analisa Univariat dan Bivariat menggunakan analisis uji t.Hasil penelitian didapat Rata-rata kadar Hb pada Ibu hamil sebelum mengkonsumsi kapsul ekstrak daun kelor adalah 9,835 gr%. Rata-rata kadar Hb pada Ibu hamil sesudah mengkonsumsi kapsul ekstrak daun kelor adalah 10,259 gr%. Ada pengaruh pemberian kapsul ekstrak daun kelor terhadap peningkatan kadar HB pada ibu hamil dengan anemia di Puskesmas Kotabumi II Kecamatan Kotabumi Selatan Kabupaten Lampung Utara p value 0,000 (0,05), berdasarkan hasil penelitian disarankan petugas kesehatan dapat memberikan informasi tentang manfaat pengobatan non farmakologi seperti daun kelor untuk meningkatkan kadar hemoglobin mencegah anemia.Kata Kunci : Kapsul Ekstrak Daun Kelor, Kadar Hb, Ibu Hamil
PENGARUH PEMBERIAN COKLAT HITAM TERHADAP PENURUNAN NYERI DISMENORE PADA REMAJA PUTRI
Authors: Lindasari Tati 
Published: October 2024

Dismenore merupakan nyeri perut bagian bawah yang dirasakan pada saat menstruasi.Hasil prasurvei di yayasan panti asuhan Alfalah Way Bandar Lampung tahun 2023, terdapat 35 remaja putri.Pada bulan April 2023, terdapat 11 remaja putri yang sedang menstruasi, 10 diantaranya mengalami dismenore.Tujuan penelitian ini adalah untuk mengetahui pengaruh pemberian coklat hitam terhadap penurunan nyeri dismenore pada remaja putri di yayasan panti asuhan Alfalah Way Dadi Bandar Lampung tahun 2023. Jenis Penelitian ini kuantitatif, desain penelitian analitik rancangan preeksperimen (One Group Pre-Post test Design).Populasi dalam penelitian ini sebanyak 35 orang remaja putri dengan sampel 15 responden yang mengalami dismenore.Sampel yang diambil menggunakan purposive sampling.Analisa bivariat menggunakan Uji T. Hasil analisa univariat didapatkan rata-rata nyeri disminore pada remaja putri sebelum pemberian coklat hitam yaitu sebesar 4,20 dan sesudah pemberian coklat hitam, yaitu sebesar 2,73 di yayasan panti asuhan Alfalah Way Dadi Bandar Lampung tahun 2023. Hasil analisa Bivariat didapatada pengaruh pemberian coklat hitam terhadap penurunan nyeri disminore pada remaja putri di yayasan panti asuhan Alfalah Way Dadi Bandar Lampung tahun 2023 (p value : 0,000). Disarankan bagi remaja putri dapat mengkonsumsi coklat hitam sebagai alternatif mengurangi dismenore saat menstruasi. Kata Kunci : Dismenore, Remaja putri, Coklat hitam, Nyeri
PENGARUH RANGE OF MOTION PASIEN GAGAL GINJAL KRONIK DI RUMAH SAKIT UMUM DAERAH DEMANG SEPULAU RAYA LAMPUNG TENGAH
Authors: Prayoga Ambar Dwi , Susanto Giri , Fredy Raju , Kurnia Heni 
Published: October 2024

ABSTRAK Penyakit Gagal Ginjal Kronis (GGK) merupakan penyakit yang bersifat irreversible atau tidak bisa menjadi sembuh total atau normal kembali. Permasalahan yang sering dikeluhkan pasien yang menjalani hemodialisa rutin ialah kelemahan otot. Latihan fisik selama hemodialisa dapat meningkatkan kekuatan otot salah satunya adalah latihan Range of motion (ROM). ROM secara dini dapat meningkatkan kekuatan otot karena dapat menstimulasi motor unit. Tujuan dalam asuhan keperawatan ini adalah mengetahui inovasi intervensi pemberian range of motion untuk kekuatan otot pada pasien gagal ginjal kronik di Rumah Sakit. Metode menggunakan design karya tulis ilmiah ini menggunakan design deskriptif. Metode penggumpulan data pada karya tulis ilmiah ini menggunakan, observasi dan inovasi intervensi pemberian range of motion untuk kekuatan otot pada pasien gagal ginjal kronik yang telah dipilih. Hasil asuhan keperawatan yang dilakukan maka kesimpulan didapatkan 4 responden dengan keluhan utama kelemahan anggota gerak. Intervensi untuk penurunan kekuatan otot dapat dilakukan dengan terapi aktivitas menggunakan terapi ROM. Diharapkan intervensi ini dapat dilakukan untuk menambah pengetahuan, pengalaman tentang pemberian range of motion untuk kekuatan otor pada pasien gagal ginjal kronik di Rumah Sakit, sehingga pasien dapat mengaplikasikan serta membagikan pengalamanya kepada pasien gagal ginjal lainnya. Pasien dapat melakukan range of motion sehari-hari guna meningkatkan kekuatan otot Kata Kunci : Range of motion (ROM), Gagal Ginjal Kronis, Kekuatan Otot
ANALISIS PROTEIN DAN ZAT BESI BISKUIT TEPUNG IKAN LELE DAN TEPUNG LABU KUNING SEBAGAI PEMBERIAN MAKANAN TAMBAHAN IBU HAMIL ANEMIA
Authors: Artina Shera , Wati Desti Ambar , Muharramah Alifiyanti , Junita Dera Elva 
Published: October 2024

ABSTRAK Prevalensi Anemia Ibu Hamil di Provinsi Lampung tahun 2019 sebesar 23,2%, Kandungan protein pada ikan lele sebesar 17gr/100gr dan zat besi 150 mg/100 gr, labu kuning kandungan protein sebesar 1,7 mg/100gr dan zat besi 0,7 mg/100gr. Biskuit tepung ikan lele dan tepung labu kuning sebagai makanan tambahan ibu hamil anemia merupakan alternatif produk pangan fungsional dapat mencegah anemia.Tujuan penelitian ini untuk menganalisis kadar protein dan zat besi biskuit tepung ikan lele dan tepung labu kuning serta mengetahui formula biskuit yang memiliki kandungan protein dan zat besi paling tinggi.Jenis penelitian adalah eksperimental, dengan RAL (Rancangan Acak Lengkap) yakni dilakukan dengan 4 perlakuan menggunakan substitusi tepung ikan lele dan tepung labu kuning yaitu F0 (0%),F1 (20%),F2 (30%), dan F3 (40%). Kandungan protein menggunakan metode Gunning dan zat besi menggunakan metode Spektrofotometri Serapan Atom, SSA. Perbedaan perlakuan masing-masing di analisis dengan uji Anova dan dilanjutkan dengan uji Duncan’s.Hasil penelitian p-value pada kandungan protein p = 0,000 dan zat besi p = 0,0045. Kadar protein paling tinggi pada F3 (40%) sebesar 14,34% dapat memenuhi 100% kebutuhan PMT pada ibu hamil dan kadar zat besi paling tinggi pada F3 (40%) sebesar 0,0115% yang dapat memenuhi 46% kebutuhan PMT pada ibu hamil.Berdasarkan hasil penelitian bahwa semakin banyak tepung ikan lele dan tepung labu kuning yang ditambahkan maka semakin tinggi kadar protein dan zat besi pada biskuit.Kata Kunci : Protein, Zat Besi, Tepung Ikan Lele, Tepung Labu Kuning, Biskuit