bluuebunny/crossref_metadata_2025_split huggingface dataset:
Applying minerals to soil to draw down atmospheric carbon dioxide through synergistic organic and inorganic pathways
Authors: Buss Wolfram , Hasemer Heath , Sokol Noah W. , Rohling Eelco J. , Borevitz Justin 
Published: October 2024

AbstractMinerals in soil can sequester atmospheric carbon dioxide through natural organic and inorganic processes. Here we consider three soil- and mineral-based methods for carbon dioxide removal: (1) grinding and spreading of calcium- and magnesium-rich silicate rocks for enhanced rock weathering and subsequent inorganic carbon formation, (2) mineral doping of biomass prior to conversion into biochar for enhanced biochar carbon yield and stability, and (3) strategic application of minerals to soil to increase soil organic carbon accrual and stability. We argue that there are powerful synergies between these approaches for carbon dioxide removal through organic and inorganic pathways. We find that primary silicates, as contained in basalt, can benefit both enhanced weathering and soil organic carbon formation, while phyllosilicates and other reactive secondary minerals may have positive synergies for biochar and soil organic carbon. Optimising such synergies may substantially enhance economic and environmental benefits, yet these synergies require accurate quantification.
Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer
Authors: Wahi Kanu , Freidman Natasha , Wang Qian , Devadason Michelle , Quek Lake-Ee , Pang Angel , Lloyd Larissa , Larance Mark , Zanini Fabio , Harvey Kate , O’Toole Sandra , Guan Yi Fang , Holst Jeff 
Published: October 2024

AbstractTriple-negative breast cancer (TNBC) metabolism and cell growth uniquely rely on glutamine uptake by the transporter ASCT2. Despite previous data reporting cell growth inhibition after ASCT2 knockdown, we here show that ASCT2 CRISPR knockout is tolerated by TNBC cell lines. Despite the loss of a glutamine transporter and low rate of glutamine uptake, intracellular glutamine steady-state levels were increased in ASCT2 knockout compared to control cells. Proteomics analysis revealed upregulation of macropinocytosis, reduction in glutamine efflux and increased glutamine synthesis in ASCT2 knockout cells. Deletion of ASCT2 in the TNBC cell line HCC1806 induced a strong increase in macropinocytosis across five ASCT2 knockout clones, compared to a modest increase in ASCT2 knockdown. In contrast, ASCT2 knockout impaired cell proliferation in the non-macropinocytic HCC1569 breast cancer cells. These data identify macropinocytosis as a critical secondary glutamine acquisition pathway in TNBC and a novel resistance mechanism to strategies targeting glutamine uptake alone. Despite this adaptation, TNBC cells continue to rely on glutamine metabolism for their growth, providing a rationale for targeting of more downstream glutamine metabolism components.
RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer
Authors: Uchida Yutaro , Kurimoto Ryota , Chiba Tomoki , Matsushima Takahide , Oda Goshi , Onishi Iichiroh , Takeuchi Yasuto , Gotoh Noriko , Asahara Hiroshi 
Published: October 2024

AbstractTriple-negative breast cancer (TNBC) lacks the expression of hormone and HER2 receptors and is highly malignant with no effective therapeutic targets. In TNBC, the cancer stem-like cell (CSC) population is considered to be the main cause of resistance to treatment. Thus, the therapeutic targeting of this population could substantially improve patient survival. Here, we identify the RNA-binding protein ZCCHC24 as enriched in the mesenchymal-like TNBC population. ZCCHC24 promotes the expression of a set of genes related to tumorigenicity and treatment resistance by directly binding to the cis-element “UGUWHWWA” in their mRNAs, thereby stabilizing them. One of the ZCCHC24 targets, ZEB1, is a transcription factor that promotes the expression of cancer stemness genes and reciprocally induces ZCCHC24 expression. ZCCHC24 knockdown by siRNAs shows a therapeutic effect and reduces the mesenchymal-like cell population in TNBC patient-derived xenografts. ZCCHC24 knockdown also has additive effects with the BET inhibitor JQ1 in suppressing tumor growth in TNBC patient-derived xenografts.
Carbon-supported Au25 cluster catalysts partially decorated with dendron thiolates: enhanced loading weight and durability for hydrogen evolution reaction
Authors: Sakamoto Kosuke , Masuda Shinya , Takano Shinjiro , Tsukuda Tatsuya 
Published: October 2024

The loading amount and durability of the carbon-supported Au25 cluster catalyst were successfully enhanced by introducing bulky, dendron thiolates, due to (1) strong non-covalent interactions between ligands and support, and (2) steric repulsion.
Artificial Intelligence and the Future of Communication Sciences and Disorders: A Bibliometric and Visualization Analysis
Authors: Zhang Minyue , Tang Enze , Ding Hongwei , Zhang Yang 
Published: October 2024

Purpose:
As artificial intelligence (AI) takes an increasingly prominent role in health care, a growing body of research is being dedicated to its application in the investigation of communication sciences and disorders (CSD). This study aims to provide a comprehensive overview, serving as a valuable resource for researchers, developers, and professionals seeking to comprehend the evolving landscape of AI in CSD research.

Method:
We conducted a bibliometric analysis of AI-based research in the discipline of CSD published up to December 2023. Utilizing the Web of Science and Scopus databases, we identified 15,035 publications, with 4,375 meeting our inclusion criteria. Based on the bibliometric data, we examined publication trends and patterns, characteristics of research activities, and research hotspot tendencies.

Results:
From 1985 onwards, there has been a consistent annual increase in publications, averaging 16.51%, notably surging from 2012 to 2023. The primary communication disorders studied include autism, aphasia, dysarthria, Parkinson's disease, and Alzheimer's disease. Noteworthy AI models instantiated in CSD research encompass support vector machine, convolutional neural network, and hidden Markov model, among others.

Conclusions:
Compared to AI applications in other fields, the adoption of AI in CSD has lagged slightly behind. While CSD studies primarily use classical machine learning techniques, there is a growing trend toward the integration of deep learning methods. AI technology offers significant benefits for both research and clinical practice in CSD, but it also presents certain challenges. Moving forward, collaboration among technological, research, and clinical domains is essential to empower researchers and speech-language pathologists to effectively leverage AI technology for the study, diagnosis, assessment, and rehabilitation of CSD.

Supplemental Material:

https://doi.org/10.23641/asha.27162564
High‐speed main protection for multiterminal LCC‐MMC‐UHVDC based on initial wave process comparison
Authors: Li Yan , Li Jun , Li Guiyuan , Cao Runbin , Zeng Xinjie , Tong Ning 
Published: October 2024

AbstractThe multiterminal LCC‐MMC‐UHVDC, which employs an LCC on the rectifier side and multiple FHMMCs on the inverter side, has emerged as a cutting‐edge technology. Nevertheless, distinct disparities in their protection requirements compared to those of conventional DC grids pose notable challenges in attaining the desired attributes. This paper first derives variation patterns in the time domain of initial waves under different fault conditions. By utilizing the theoretically calculated rate‐of‐change waveform for the backward current traveling wave in an external fault scenario as a reference, a main protection relay grounded in initial wave process comparison is proposed. This approach capitalizes on the disparity observed in internal faults with the theoretical waveform. To mitigate maloperations stemming from the employment of a non‐directional start‐up criterion in reverse fault scenarios, subtle noise patterns, mimicking the theoretical waveforms, are infused into the actual waveforms. This approach averts maloperations in reverse faults and obviates the need for added delays associated with directional start‐up criteria, thereby enhancing both speed and security. Case studies demonstrate that the proposed protection offers sufficient selectivity and a resistive tolerance of 600 ohms and boasts a speed of 0.2 ms, satisfying the requirements of 800 kV UHVDC systems.
In situ monitoring of defects in steel structures using a robot‐assisted ultrasonic inspection technique
Authors: Besharatifard Hamidreza , Hasanzadeh Saeed 
Published: October 2024

AbstractIncidents in extreme environments can bring unprecedented consequences that would endanger the lives of many humans. Real‐time and early detection of cracks and defects in the steel used for the construction of industrial sites can bring many benefits to remote operators and site managers. Although different methods and systems have been proposed in the past, they are not suitable for real‐time fault detection or long‐term operation in harsh environments. Therefore, this paper proposes a low‐power robotic platform with a magnetic actuator mechanism which is capable of wireless inspection of steel structures using the ultrasonic method. The proposed magnetic motion uses the inertia force generated by the piston vibration and the difference in frictional force during movement. The paper evaluates the performance of the steel structure defect detection system from four different perspectives: sensing principle, wireless communication network, driving part, and power supply.
Discovery of a > 13 Mpc long X-ray filament between two galaxy clusters beyond three times their virial radii
Authors: Dietl J. , Pacaud F. , Reiprich T. H. , Veronica A. , Migkas K. , Spinelli C. , Dolag K. , Seidel B. 
Published: October 2024

Context. A significant fraction of the missing baryons in the local Universe is expected to reside in large-scale filaments that may be observable in soft X-ray emission. Until now, however, very few candidate emission filaments have been found in individual systems, and none beyond three times the virial radius of the clusters at the nodes of these filaments. The new Spectrum Roentgen Gamma (SRG) eROSITA X-ray telescope has a superior response to extended soft X-rays, which makes it ideal for studying low X-ray surface brightness emission of cosmic filaments.
Aims. We search for extended X-ray emission between the two nearby galaxy clusters Abell 3667 and Abell 3651, which are separated by a projected transverse distance of ~13 Mpc, using data from the SRG/eROSITA All-Sky Survey.
Methods. We performed a detailed X-ray image analysis of the region between the two galaxy clusters and conducted a redshift analysis of the sources between them. We carried out a thorough surface brightness and spectral analysis between the clusters. The analysis was complemented with an X-ray pointed observation from XMM-Newton, infrared 2MASS data, and redshift information from NED.
Results. We discover an emission filament beyond the known radio relic northwest of A3667 and even beyond three times its virial radius. It is smoothly connected to A3651. The X-ray emission in the direction of the filament shows an enhancement of (30 ± 3) % with a significance of 11 σ. The 2MASS map and redshift analysis show an alignment of galaxies along the filament and make a projection effect unlikely. Taking the redshift progression of galaxies within the filament into account, we estimate its three-dimensional length to be in the range of 25 Mpc–32 Mpc. The surface brightness analysis in combination with the temperature T = (0.91−0.11+0.07) keV and metallicity Z = (0.10−0.08+0.05) Z⊙ from the spectral analysis leads to estimates of a total flux, gas mass, and central baryon overdensity of FX = (7.4 ± 1.2)×10−12 erg s−1 cm−2, Mg = (2.7−0.8+1.4) M⊙ and δ0 = 215−50+86.
The MUSE eXtremely Deep Field: Detections of circumgalactic Si II* emission at z  ≳  2
Authors: Kusakabe Haruka , Mauerhofer Valentin , Verhamme Anne , Garel Thibault , Blaizot Jérémy , Wisotzki Lutz , Richard Johan , Boogaard Leindert A. , Leclercq Floriane , Guo Yucheng , Claeyssens Adélaïde , Contini Thierry , Herenz Edmund Christian , Kerutt Josephine , Maseda Michael V. , Michel-Dansac Leo , Nanayakkara Themiya , Ouchi Masami , Pessa Ismael , Schaye Joop 
Published: October 2024

Context. The circumgalactic medium (CGM) serves as a baryon reservoir that connects galaxies to the intergalactic medium and fuels star formation. The spatial distribution of the metal-enriched cool CGM has not yet been directly revealed at cosmic noon (z ≃ 2–4), as bright emission lines at these redshifts are not covered by optical integral field units.
Aims. To remedy this situation, we performed the first-ever detections and exploration of extended Si II* emission in the low-ionization state (LIS), referred to as Si II* halos, at redshifts ranging from z = 2 to 4 as a way to trace the metal-enriched cool CGM.
Methods. We used a sample of 39 galaxies with systemic redshifts of z = 2.1–3.9 measured with the [C III] doublet in the MUSE Hubble Ultra Deep Field catalog, whose integration times span from ≃30 to 140 hours. We searched for extended Si II* λ1265, 1309, 1533 emission (fluorescent lines) around individual galaxies. We also stacked a subsample of 14 UV-bright galaxies.
Results. We report five individual detections of Si II* λ1533 halos. We also confirm the presence of Si II* λ1533 halos in stacks for the subsample containing UV-bright sources. The other lines do not show secure detections of extended emission in individual or in stacking analyses. These detections may imply that the presence of metal-enriched CGM is a common characteristic for UV-bright galaxies. To investigate whether the origin of Si II* is continuum pumping, as suggested in previous studies, we checked the consistency of the equivalent width (EW) of Si II* emission and the EW of Si II absorption for the individual halo object with the most reliable detection. We confirm the equivalence, suggesting that photon conservation works for this object and points toward continuum pumping as the source of Si II*. We also investigated Si II* lines in a RAMSES-RT zoom-in simulation including continuum pumping, and find the ubiquitous presence of extended halos.
J-PLUS: The fraction of calcium white dwarfs along the cooling sequence
Authors: López-Sanjuan C. , Tremblay P.-E. , O’Brien M. W. , Spinoso D. , Ederoclite A. , Vázquez Ramió H. , Cenarro A. J. , Marín-Franch A. , Civera T. , Carrasco J. M. , Gänsicke B. T. , Gentile Fusillo N. P. , Hernán-Caballero A. , Hollands M. A. , del Pino A. , Domínguez Sánchez H. , Fernández-Ontiveros J. A. , Jiménez-Esteban F. M. , Rebassa-Mansergas A. , Schmidtobreick L. , Angulo R. E. , Cristóbal-Hornillos D. , Dupke R. A. , Hernández-Monteagudo C. , Moles M. , Sodré L. , Varela J. 
Published: October 2024

Aims. We used the Javalambre Photometric Local Universe Survey (J-PLUS) second data release (DR2) photometry in 12 optical bands over 2176 deg2 to estimate the fraction of white dwarfs with the presence of Ca II H+K absorption along the cooling sequence.
Methods. We compared the J-PLUS photometry against metal-free theoretical models to estimate the equivalent width in the J0395 passband of 10 nm centered at 395 nm (EWJ0395), a proxy to detect calcium absorption. A total of 4399 white dwarfs with effective temperatures within 30 000 > Teff > 5500 K and masses of M > 0.45 M⊙ were analyzed. Their EWJ0395 distribution was modeled using two populations, corresponding to polluted and non-polluted systems, to estimate the fraction of calcium white dwarfs (fCa) as a function of Teff. The probability of each individual white dwarf presenting calcium absorption, pCa, was also computed.
Results. The comparison of EWJ0395 with both the measured Ca/He abundance and the identification of metal pollution from spectroscopy shows that EWJ0395 correlates with the presence of Ca II H+K absorption. The fraction of calcium white dwarfs changes along the cooling sequence, increasing from fCa ≈ 0 at Teff = 13 500 K to fCa ≈ 0.15 at Teff = 5500 K. This trend reflects the selection function of calcium white dwarfs in the optical. We compare our results with the fractions derived from the 40 pc spectroscopic sample and from Sloan Digital Sky Survey (SDSS) spectra. The trend found in J-PLUS observations is also present in the 40 pc sample; however, SDSS shows a deficit of metal-polluted objects at Teff < 12 000 K. Finally, we found 39 white dwarfs with pCa > 0.99. Twenty of them have spectra presented in previous studies, whereas we obtained follow-up spectroscopic observations for six additional targets. These 26 objects were all confirmed as metal-polluted systems.
Conclusions. The J-PLUS optical data provide a robust statistical measurement for the presence of Ca II H+K absorption in white dwarfs. We find a 15 ± 3% increase in the fraction of calcium white dwarfs from Teff = 13 500 K to 5500 K, which reflects their selection function in the optical from the total population of metal-polluted systems.
Evaluation of Echinacea purpurea Extracts as Immunostimulants: Impact on Macrophage Activation
Authors: Vieira Sara F. , Gonçalves Samuel M. , Gonçalves Virgínia M. F. , Tiritan Maria E. , Cunha Cristina , Carvalho Agostinho , Reis Rui L. , Ferreira Helena , Neves Nuno M. 
Published: October 2024

Abstract
Echinacea purpurea has been traditionally used to strengthen the immune system. Therefore, herein, we investigated the potential of E. purpurea aqueous extracts (AEs) obtained from flowers (F), leaves (L), or roots (R) as an immune booster in human primary monocyte‐derived macrophages (hMDMs). Additionally, to identify the main class of compounds (phenolic/carboxylic acids vs. alkylamides) responsible for the bioactivity, the three AEs were fractioned by semi-preparative high-performance liquid chromatography (HPLC). The AEs and the isolated phenolic/carboxylic acidic fractions were not cytotoxic for hMDMs for all tested concentrations, as confirmed by the metabolic activity and DNA content assays. Moreover, AE drastically induced the production of the interleukin (IL)-6 and tumor necrosis factor (TNF)-α, with a minimal effect on IL-1β and prostaglandin E2 (PGE2), supporting their potential for macrophage activation. Interestingly, in the presence
of the phenolic/carboxylic acidic fractions, this efficacy considerably decreased, suggesting a complementary effect between compounds. AE also triggered the phosphorylation of the extracellular signal-regulated kinase (ERK) 1/2 and p38 signaling pathways and upregulated the cyclooxygenase (COX)-2 expression in hMDMs. Overall, AE-F was demonstrated to be the most powerful immunostimulant extract that can be related to their higher number in identified bioactive compounds compared to AE-L and AE-R. These results highlight the efficiency of E. purpurea AE to enhance the function of a key cell type of the immune system and their potential as immunostimulant formulations for patients with a compromised immune system due to certain diseases (e.g., acquired immunodeficiencies) and treatments (e.g., chemotherapy).
Progressive Myoclonus Epilepsy and Beyond: A Systematic Review of SEMA6B-related Disorders
Authors: Altıntaş Mert , Yıldırım Miraç , Bektaş Ömer , Teber Serap 
Published: October 2024

AbstractProgressive myoclonus epilepsy (PME) is a rare, clinically and genetically heterogeneous epilepsy syndrome, and pathogenic variants in the semaphorin 6B (SEMA6B) gene have recently been reported to be among the causes of PME. Cases with pathogenic variants in the SEMA6B gene are extremely rare, only a limited number of cases have been reported in the literature. In this systematic review, we aimed to present a summary of a PME case in which a heterozygous nonsense variant of c.2086C > T p.(Gln696*) in the SEMA6B gene was detected in the etiology and other cases with SEMA6B pathogenic variant in the literature. Except for our case, 35 cases from 12 studies were included. The main clinical findings in these patients were cognitive problems, seizures, gait and speech disturbances, and cognitive and/or motor regression, and they had a wide spectrum of severity. Response to antiseizure medications was also highly variable, almost half of the patients had pharmacoresistant seizures. Patients were divided into four different phenotypic groups according to their clinical presentations: PME (18/36), developmental and epileptic encephalopathy (13/36), neurodevelopmental disorder (4/36), and epilepsy (1/36), respectively. In conclusion, although SEMA6B has been associated with PME, it may actually cause a much broader phenotypic spectrum. Due to their extreme rarity, our knowledge of SEMA6B-related disorders is limited. As with all other rare diseases, each new SEMA6B-related disorder case could contribute to a better understanding of the disease. A better understanding of the disease may allow the development of specific treatment options in the future.
Vanderbilt Clinical Informatics Center Education Strategy: To Infinity and Beyond!
Authors: Russo Elise , McCoy Allison , Mize Dara , Osterman Travis , Nelson Scott , Wanderer Jonathan P. , Wright Adam 
Published: October 2024

Abstract
Background The Vanderbilt Clinical Informatics Center (VCLIC) is based in the Department of Biomedical Informatics (DBMI) and operates across Vanderbilt University Medical Center (VUMC) and Vanderbilt University (VU) with a goal of enabling and supporting clinical informatics research and practice. VCLIC supports several types of applied clinical informatics teaching, including teaching of students in courses, professional education for staff and faculty throughout VUMC, and workshops and conferences that are open to the public.
Objectives In this paper, we provide a detailed accounting of our center and institution's methods of educating and training faculty, staff, students, and trainees from across the academic institution and health system on clinical informatics topics, including formal training programs and informal applied learning sessions.
Methods Through a host of informal learning events, such as workshops, seminars, conference-style events, bite-size instructive videos, and hackathons, as well as several formal education programs, such as the Clinical Informatics Graduate Course, Master's in Applied Clinical Informatics, Medical Student Integrated Science Course, Graduate Medical Education Elective, and Fellowship in Clinical Informatics, VCLIC, and VUMC provide opportunities for faculty, students, trainees, and even staff to engage with Clinical Informatics topics and learn related skills.
Results The described programs have trained hundreds of participants from across the academic and clinical enterprises. Of the VCLIC-held events, the majority of attendees indicated through surveys that they were satisfied, with the average satisfaction score being 4.63/5, and all events averaging a satisfaction score of greater than 4. Across the 20 events VCLIC has held, our largest audiences are DBMI, HealthIT operational staff, and students from the medical and nursing schools.
Conclusion VCLIC has created and delivered a successful suite of formal and informal educational events and programs to disseminate clinical informatics knowledge and skills to learners across the academic institution and health care system.