bluuebunny/crossref_metadata_2025_split huggingface dataset:
Serum BDNF levels in patients with gambling disorder are associated with the severity of gambling disorder and Iowa Gambling Task indices
Authors: Choi Sam-Wook , Shin Young-Chul , Mok Jung Yeon , Kim Dai-Jin , Choi Jung-Seok , Suk-Hyun Hwang Samuel 
Published: March 2016

Background and aims
Gambling disorder (GD) shares many similarities with substance use disorders (SUDs) in clinical, neurobiological, and neurocognitive features, including decision-making. We evaluated the relationships among, GD, decision-making, and brain-derived neurotrophic factor (BDNF), as measured by serum BDNF levels.

Methods
Twenty-one male patients with GD and 21 healthy sex- and age-matched control subjects were evaluated for associations between serum BDNF levels and the Problem Gambling Severity Index (PGSI), as well as between serum BDNF levels and Iowa Gambling Task (IGT) indices.

Results
The mean serum BDNF levels were significantly increased in patients with GD compared to healthy controls. A significant correlation between serum BDNF levels and PGSI scores was found when controlling for age, depression, and duration of GD. A significant negative correlation was obtained between serum BDNF levels and IGT improvement scores.

Discussion
These findings support the hypothesis that serum BDNF levels constitute a dual biomarker for the neuroendocrine changes and the severity of GD in patients. Serum BDNF level may serve as an indicator of poor decision-making performance and learning processes in GD and help to identify the common physiological underpinnings between GD and SUDs.
Risky online behaviors among adolescents: Longitudinal relations among problematic Internet use, cyberbullying perpetration, and meeting strangers online
Authors: Gámez-Guadix Manuel , Borrajo Erika , Almendros Carmen 
Published: March 2016

Background and aims
This study aims to analyze the cross-sectional and longitudinal relationship between three major risky online behaviors during adolescence: problematic Internet use, cyberbullying perpetration, and meeting strangers online. An additional objective was to study the role of impulsivity–irresponsibility as a possible explanatory variable of the relationships between these risky online behaviors.

Methods
The study sample was 888 adolescents that completed self-report measures at time 1 and time 2 with an interval of 6 months.

Results
The findings showed a significant cross-sectional relationship between the risky online behaviors analyzed. At the longitudinal level, problematic Internet use at time 1 predicted an increase in the perpetration of cyberbullying and meeting strangers online at time 2. Furthermore, meeting strangers online increased the likelihood of cyberbullying perpetration at time 2. Finally, when impulsivity–irresponsibility was included in the model as an explanatory variable, the relationships previously found remained significant.

Discussion
These results extend traditional problem behavior theory during adolescence, also supporting a relationship between different risky behaviors in cyberspace. In addition, findings highlighted the role of problematic Internet use, which increased the chances of developing cyberbullying perpetration and meeting strangers online over time. However, the results suggest a limited role of impulsivity–irresponsibility as an explicative mechanism.

Conclusions
The findings suggest that various online risk activities ought to be addressed together when planning assessment, prevention and intervention efforts.
MET Exon 14 Skipping in Non-Small Cell Lung Cancer
Authors: Heist Rebecca S. , Shim Hyo Sup , Gingipally Shalini , Mino-Kenudson Mari , Le Long , Gainor Justin F. , Zheng Zongli , Aryee Martin , Xia Junfeng , Jia Peilin , Jin Hailing , Zhao Zhongming , Pao William , Engelman Jeffrey A. , Iafrate A. John 
Published: March 2016

Abstract

Background.
Non-small cell lung cancers (NSCLCs) harboring specific genetic alterations can be highly sensitive to targeted therapies.

Materials and Methods.
We performed a targeted rearrangement assay on 54 NSCLCs across all stages that were from patients who were never smokers and did not have driver mutations. Because MET exon 14 skipping was the most frequent alteration found, we surveyed the results for MET exon 14 skipping at Massachusetts General Hospital (MGH) since the inclusion of this alteration into our current molecular profiling panel.

Results.
In a cohort of 54 never-smokers with lung cancers that were wild-type for known driver mutations, MET exon 14 skipping was the most frequently recurring alteration, occurring in 10 cancers (19%). Clinical testing at MGH via our next-generation sequencing (NGS) and NGS-rearrangement panels showed an additional 16 cases of MET exon 14 skipping, for an overall estimated frequency of 5.6%. A clinical case of a patient with MET exon 14 skipping treated with the MET inhibitor crizotinib is also described.

Conclusion.
MET exon 14 skipping is a targetable gene alteration found in NSCLC. Patients with these alterations may respond well to MET inhibition.
MAIORA TIBI TRIUNFO DINÁSTICO DE FELIPE II NA ALEGORIA DA BATALHA DE LEPANTO (C. 1573-1575), DE TICIANO VECELLIO * MAIORA TIBI DYNASTIC TRIUMPH OF PHILIP II IN THE ALLEGORY OF THE BATTLE OF LEPANTO (C. 1573-1575), BY TITIAN VECELLIO
Authors: Padilha Vieira Júnior Rivadávia 
Published: March 2016

Resumo: Este estudo propõe uma análise centrada na pintura Felipe II, después de la victoria de Lepanto, ofrece al cielo al príncipe don Fernando (Madri, Museu do Prado), de Ticiano Vecellio. Produzida em resposta à encomenda do rei espanhol Felipe II, teve por intenção celebrar dois momentos marcantes de seu reinado no ano de 1571: a vitória sobre a frota turca na batalha de Lepanto e o nascimento de seu herdeiro, o infante Dom Fernando. Com o objetivo de compreender os sentidos e funções do objeto imagético nesse contexto, a linguagem simbólica da pintura é interpretada em conexão com os acontecimentos contemporâneos à sua produção. Apesar de ser reconhecida como a “alegoria da batalha de Lepanto”, de facto, esta é representada em último plano, eclipsada por uma série de elementos carregados de simbolismo dinástico e religioso. Palavras-chave: Felipe II de Espanha; Ticiano Vecellio; Batalha de Lepanto; Iconografia; História e Imagem. Abstract: This study proposes an analysis focused on the painting Felipe II , después de la victoria de Lepanto, ofrece al cielo al prince don Fernando (Madrid, Museum of Prado), by Titian Vecellio. It was produced in response to the request of the Spanish King Philip II, with the intention to celebrate two key moments of his reign in the year 1571: the victory over the turkish fleet at the Battle of Lepanto and the birth of his heir, the infante Don Fernando. In order to understand the meanings and functions of imagery object in this context, the symbolic language of painting is interpreted in connection with contemporary events to its production. Despite being recognized as the "Allegory of the Battle of Lepanto", in fact, this is represented in the last level, eclipsed by a series of loaded elements of dynastic and religious symbolism. Keywords: Philip II ofSpain; Titian Vecellio;Battle of Lepanto; Iconography; History and Image.
O MILAGRE POLÍTICO NOS TEMPOS DO DESPERTAR DO GIGANTE: A “DITABRANDA” LUSO-BRASILEIRA EM QUESTÃO * THE POLITICAL MIRACLE IN TIMES OF GIANT AWAKENING: THE LUSO-BRAZILIAN "DITABRANDA" IN QUESTION
Authors: De Godoy Del Picchia Zanoni Fábio 
Published: March 2016

Resumo: O objetivo deste artigo consiste em argumentar como a brandura impingida à ditadura de 1964 é herdeira de uma racionalidade montada desde os primórdios da década de 1930, tanto no Brasil quanto em Portugal. A partir do arsenal teórico foucaultiano, anseia-se por trazer à baila o modo pelo qual a ditadura de Getúlio Vargas e António Salazar, muito mais do que simplesmente eclipsar as práticas violentas levadas a cabo pelos respectivos Estados, construíram ditos e escritos que tinham precisamente o condão de conciliar métodos ditatoriais e pacificação do corpo social. Palavras-chave: Ditadura; Violência; Getúlio Vargas; António Salazar; Foucault . Abstract: The purpose of this article is to argue how the gentleness impinged on the 1964 dictatorship is inheritor of a rationality assembled since the beginning of the 1930s, both in Brazil and in Portugal. From this theoretical theoretical arsenal, one yearns by bringing up the way the dictatorship of Getúlio Vargas and Antonio Salazar, much more than simply eclipse the violent practices carried out by the respective States, built sayings and writings that had precisely the power to reconcile dictatorial methods and pacification of the social body. Keywords: Dictatorship; Violence; Getúlio Vargas; António Salazar; Foucault.
SOBRE MATADORES DE DRAGÕES: ALUSÕES POÉTICAS AO HEROI SIGURÐR FÁFNISBANI E AO ARCANJO MIGUEL NA POESIA ESCANDINAVA DO SÉCULO XI * ON DRAGON SLAYERS: POETIC ALLUSIONS ABOUT THE HERO SIGURÐR FÁFNISBANI AND MICHAEL THE ARCHANGEL IN SKALDIC POETRY (XIth CENTURY)
Authors: Birro Renan Marques 
Published: March 2016

Resumo: Este artículo versa sobre diferentes tradições de matadores de dragões na Escandinávia medieval, a saber, Sigurðr Fáfnisbani e são Miguel arcanjo. A partir das transformações religiosas do período, das adequações poéticas ao novo credo e conforme a audiência, os skáld teciam suas composições, no intuito de permanecer com os favores da aristocracia escandinava. É verossímil, portanto, que a influência cristã tenha contribuído para moldar algumas composições poéticas semilegendárias e mitológicas desde a etapa de criação. É verossímil, portanto, que a influência cristã era sentida na composição de poemas semilegendários e mitológicos em língua vernacular. Palavras-chave: Sigurðr; Miguel; Poesia Escáldica; Escandinávia Medieval. Abstract: This article explores two traditions on dragon slayers in Medieval Scandinavia, i.e., Sigurðr Fáfnisbani and saint Michael theArchangel. Considering the religious transformations at that time, the poetical changes with the introduction of a new faith, and the audience reception, the skáld “wove” their compositions to maintain their favorable positions among the scandinavian aristocracy. Possibly the christian influence was present since the composition of semi legendary and mythological poems in vernacular language. Keywords: Sigurðr; Michael; Skaldic Poetry; MedievalScandinavia.
A ATIVIDADE DA PESCA E OS DIREITOS DOS TRABALHADORES DA PESCA NO BRASIL NAS PRÁTICAS POLÍTICAS DE CARLOS DA SILVA SANTOS * THE FISHERY AND WORKERS ' RIGHTS OF FISHING IN BRAZIL IN THE PRACTICES POLICIES OF CARLOS DA SILVA SANTOS
Authors: Gomes Arilson Dos Santos 
Published: March 2016

Resumo: Este trabalho visa analisar os temas referentes à atividade da pesca e aos direitos dos trabalhadores da pesca identificados na prática política de Carlos da Silva Santos. Neto de ex-escravizados, o político desde a década de 1930 destacou-se como líder sindical. Orador de reconhecida qualidade, entre os anos de 1959 e 1974, por quatro vezes consecutivas elegeu-se deputado estadual pelo Estado do Rio Grande do Sul, perfazendo uma carreira sólida, inclusive ocupando por duas vezes o cargo de governador interino do Estado. A pesquisa efetuada por meio de fontes oficiais, cotejadas com impressos jornalísticos, permite uma dimensão dos temas propostos na agenda parlamentar defendida pelo tribuno, com destaque para o tema da atividade da pesca e dos direitos dos pescadores. Palavras-chave: Carlos Santos; Análise discursiva; Pesca; Nova História Política; Direitos. Abstract: This work aims to analyze what were the themes of the fishery and workers ‘rights of fishing identified in the discursive trajectory of political Carlos da SilvaSantos. Grandson of former slaves, since the 1930s stood out as union leader. Preacher of recognized quality, between the years 1959 and 1974 for four consecutive times was elected state deputy the state of Rio Grande do Sul, making a solid career, including occupying the position of acting governor of the state. The research conducted by official sources, collated with printed newspaper, allows a dimension of topics proposed by the parliamentary, highlighting the theme of fishing activity and the rights of fishermen. Abstract: Carlos Santos; Discursive analysis; Fishing; New Political History; Rights.
A LIVRARIA DE D. DUARTE (1433-1438) E SEUS LIVROS EM LINGUAGEM * THE D. DUARTE LIBRARY (1433-1438) AND ITS BOOKS ON LINGUAGEM
Authors: Ferro Carolina Chaves 
Published: March 2016

Resumo: D. Duarte (1433-1438) reinou apenas cinco anos, mas deixou um importante legado: a ampliação da cultura letrada em Portugal. Esta foi uma das estratégias da Dinastia de Avis para legitimar sua corte e sua linhagem como aqueles que fariam o reino crescer em importância econômica, política e cultural. Neste sentido, a propagação das traduções foi um dos instrumentos utilizados para que as obras escritas alcançassem um número maior de pessoas, notadamente os nobres. Este artigo pretende apontar o início da língua vulgar em Portugal Medieval focando, principalmente, no rei D. Duarte, um dos grandes incentivadores da produção e guarda de livros no período, demonstrando a importância dessas obras para a consolidação de uma nova nobreza que ascendeu ao poder.Palavras-chave: D. Duarte; Portugal Medieval; Livros; Biblioteca; Português. Abstract: D.Duarte (1433-1438) reigned only five years, but he left an important legacy: the expansion of literacy inPortugal. That was one of the strategies of the Avis Dinasty to to legitimize his court and his lineage as those that would make the kingdom grow in economic, political and cultural importance. In this sense, the spread of the translations was one of the instruments used for the books reached a larger number of people, especially the nobles. This article pretends to show the beginning of the vernacular in Medieval Portugal, focusing mainly on the king D. Duarte, one of the supporters of the production and custody of books in the period, demonstrating the importance of these Works for the consolidation of a new nobility who came to power.Keywords: D. Duarte; Medieval Portugal; Books; Library; Portuguese.
A LITERATURA DEVOCIONAL EM LÍNGUA VERNÁCULA E A REFORMA DOS CUIDADOS COM OS ENFERMOS NO PORTUGAL TARDO-MEDIEVAL: A CARIDADE, A ASSISTÊNCIA E A MISERICÓRDIA. * LITERATURE DEVOTIONAL IN THE VERNACULAR AND CARE REFORM WITH SICK IN PORTUGAL LATE MEDIEVAL: CHARITY, ASSISTANCE AND THE MERCY.
Authors: Silva André Costa Aciole da 
Published: March 2016

Resumo:O objetivo deste artigo é demonstrar como a literatura devocional, em língua portuguesa, colaborou para a difusão de uma série de ideias associadas à caridade, assistência e misericórdia que orientaram as práticas régias e sociais de apoio aos enfermos. Dar-se-á destaque a duas instituições portuguesas criadas em fins da Idade Média: o Hospital de Todos os Santos, em Lisboa e o Hospital de Nossa Senhora do Pópulo, nas Caldas da Rainha como exemplo da reforma da assistência aos enfermos.Palavras-Chave:Assistência, enfermos, hospitais, Idade Média, Portugal, literatura devocional. Abstract: The purpose of this article is to demonstrate how the devotional literature in Portuguese, contributed to the spread of a number of ideas associated with love, care with the sicks and mercy that guided the royal and social practices of support to the sick. We will highlight the two Portuguese institutions created in the late Middle Ages: theHospital ofAll Saints inLisbon and the Hospital of Our Lady of Populo, in Caldas da Rainha as example of reform of the care of the sick.Keywords: Care, sick, hospitals, Middle Ages,Portugal, devotional literature.
Wellness Tourism: Using Tourists' Preferences To Evaluate The Wellness Tourism Market In Jamaica
Authors: Valentine Nadine Angelita 
Published: March 2016

<p>This study sought to evaluate the general wellness preferences of tourists in Jamaica as there is little information to support the body of knowledge on these tourists' wellness preferences to Jamaica and to successfully facilitate segmentation in the wellness tourism market. Therefore, a framework is needed to align the push factors of tourists’ wellness expectations with the pull factors of tourism's offerings.</p><p>The research examined the tourists' socio - demographic profile, their travel characteristics and the importance of wellness to them. Additionally, it investigated preferred amenities and services, the natural resources associated with particular accommodations, the type of accommodations preferred for a wellness vacation and the locations' attractive attributes. The quantitative results showed that wellness was important however, young people, retirees and higher income earners were not well represented. Strong preferences exists for natural remedies, wellness competencies and mind therapies. Low preferences exist for culinary tours, mineral baths, community involvement and nature experiences. Despite the location's reported physical attractiveness , hotels were preferred for a wellness vacation and many natural and historic features were unexplored.</p><p>The findings suggest that tourists have aligned themselves with the existing tourism offerings and that the preferences identified can facilitate ‘new forms’ of tourism. There may be an alignment with the vocational training system, tourism marketing efforts and international standards. Infrastructural development may also be facilitated around naturally occurring springs, heritage sites, historical buildings and unexplored natural highlights. Local businesses and communities may also benefit from the unique wellness preferences. This emphasis will subsequently support workplace wellness and primary health care. </p>
Restauración ecológica del suelo aplicando biochar (carbón vegetal), y su efecto en la producción de Medicago sativa
Authors: Fiallos-Ortega Luis Rafael , Flores-Mancheno Luis Gerardo , Duchi-Duchi Nelson , Flores-Mancheno Cesar Ivan , Baño-Ayala Darío , Estrada-Orozco Luis 
Published: March 2016

<p>En la provincia de Chimborazo (Ecuador), cantón Riobamba, barrio San Pedro de las Abras, se realizó el estudio de restauración ecológica del suelo mediante la aplicación de diferentes niveles de carbón vegetal (10, 20, y 30 t.ha-1) y se evaluó su efecto en la producción forrajera de alfalfa Medicago sativa, bajo un Diseño de Bloques Completamente al Azar. Los resultados superiores se obtuvieron al aplicar 30 t.ha-1 de carbón vegetal, así: en el primer corte se alcanzó el menor tiempo de ocurrencia a la floración (40,50 días), la mayor cobertura basal (39,35 %), la mayor cobertura aérea (86,0%), la mejor altura (87,98 cm), el mayor número de hojas por tallo (103,45) y, sobre todo, la mayor producción en forraje, tanto en materia verde (15,80 tFVha-1corte) como en seca(33,38 tMSha-1año), y en el segundo corte se alcanzó la mejor cobertura basal (86,55%)y aérea (95,42%), así como la mayor producción en forraje verde (15,92 t.ha-1corte) y en materia seca (33,70 t.ha-1 año). El análisis económico registró la mayor rentabilidad con30 t.ha-1 de carbón vegetal con un beneficio-costo de 1,63. Se recomienda aplicar en Medicago sativa, 30 t.ha-1 de carbón vegetal, por cuanto con esa cifra se obtuvo mayor cantidad de forraje verde por corte y se mejoró la calidad del suelo, lo que garantizará obtener rentabilidades económicas que beneficien a los productores y ganaderos, además de mejorar la calidad de los suelos.</p>
Efecto antifúngico de hidrodestilados de Zingiber officinale Roscoe sobre Moniliophthora roreri (Cif&Par)
Authors: Joya-Dávila José Gregorio , Ramírez-González Sandra Isabel , López-Báez Orlando , Alvarado-Gaona Álvaro Enrique 
Published: March 2016

<p>La moniliasis, ocasionada por el hongo Moniliophthora roreri (Cif. &amp; Par), es la principal enfermedad del cacao en Latinoamérica, y las medidas para su manejo sostenible son aún escasas. Con base en reportes previos, el objetivo de este trabajo fue optimizar el proceso de extracción por destilación de Zingiber officinale, evaluando in vitro su efecto antifúngico sobre conidias de M. roreri. Se elaboraron ocho hidrodestilados con material fresco (300 y 600 g/L) y seco al sol (45 y 90 g/L), con dos solventes (agua-alcohol, relación 10:1 y 10:0), y en tubos de ensayo con conidias del hongo, mediante la técnica de cultivo en medio líquido (agua-extracto de cacao), se adicionó cada hidrodestilado de Z. officinale en relación 1:1 v/v, determinando su efecto sobre la formación y germinación de conidias del hongo en cinco momentos de observación (0, 24, 48, 72 y 96 horas). Los resultados muestran que todos los hidrodestilados de Z. officinale presentan metabolitos con efectos de inhibición sobre las variables evaluadas, siendo el tratamiento J5 (Z. officinale seco, 45 g/L, relación 10:1 agua: alcohol) el mejor, pues alcanza el 88% y el 100% de control sobre la formación y germinación de conidias, respectivamente, con respecto al testigo absoluto a las 72 horas, siendo posible optimizar la extracción mediante destilación utilizando 45 g/L de material seco y el uso de solvente agua-alcohol en una relación 10:1.</p>
Requerimientos hídricos de la zanahoria (D. carota L.) durante tres etapas de su desarrollo
Authors: Forero-Ulloa Fabio Emilio , Cely-Reyes Germán Eduardo , Neira-Rodríguez Edilson Emilio 
Published: March 2016

<p>La zanahoria (D. carota L.) es uno de los principales productos del departamento de Boyacá, participa con 1093 ha, especialmente en los municipios de Ventaquemada, Samacá y Tunja. Los híbridos Chantenay tienen en Ventaquemada un rendimiento promedio de 20 t.ha-1, que es bajo comparado con el de la Sabana de Bogotá, de 28.1t.ha-1; las limitantes en la producción de la zona son: falta de riego, semillas de altas exigencias agronómicas (adecuada mecanización del suelo, fertilización apropiada…) y presencia de patógenos y arvenses. Con el objetivo de buscar los requerimientos hídricos del cultivo de zanahoria en tres fases fenológicas (crecimiento, elongación y madurez del órgano cosechable), el estudio se desarrolló en el segundo semestre de 2014, en Ventaquemada, vereda Bojirque; la evaluación de las fases se realizó bajo un diseño de muestreo estratificado con muestreos destructivos efectuados cada 30 días a partir de la siembra. El valor del coeficiente de cultivo (Kc) se determinó a través de la metodología propuesta por la FAO. Se instalaron dos lisímetros de 1 m3 de capacidad, con el fin de establecer el consumo hídrico del cultivo. La evapotranspiración del cultivo de referencia (ETo) fue obtenida con los datos climáticos tomados por la estación meteorológica inalámbrica Ambient Tiempo WS-2080 instalada en el sitio, los cuales se analizaron a través de la ecuación de Penman-Monteith, con el apoyo del software Cropwat. El Kc para cada etapa fenológica fue: fase crecimiento, 0.14; fase elongación, 0.29, y fase madurez órgano cosechable, 0.55.</p>