bluuebunny/crossref_metadata_2025_split huggingface dataset:
Insight into the RNA Exosome Complex Through Modeling Pontocerebellar Hypoplasia Type 1b Disease Mutations in Yeast
Authors: Fasken Milo B , Losh Jillian S , Leung Sara W , Brutus Sergine , Avin Brittany , Vaught Jillian C , Potter-Birriel Jennifer , Craig Taylor , Conn Graeme L , Mills-Lujan Katherine , Corbett Anita H , van Hoof Ambro 
Published: October 2016

Abstract
Pontocerebellar hypoplasia type 1b (PCH1b) is an autosomal recessive disorder that causes cerebellar hypoplasia and spinal motor neuron degeneration, leading to mortality in early childhood. PCH1b is caused by mutations in the RNA exosome subunit gene, EXOSC3. The RNA exosome is an evolutionarily conserved complex, consisting of nine different core subunits, and one or two 3′-5′ exoribonuclease subunits, that mediates several RNA degradation and processing steps. The goal of this study is to assess the functional consequences of the amino acid substitutions that have been identified in EXOSC3 in PCH1b patients. To analyze these EXOSC3 substitutions, we generated the corresponding amino acid substitutions in the Saccharomyces cerevisiae ortholog of EXOSC3, Rrp40. We find that the rrp40 variants corresponding to EXOSC3-G31A and -D132A do not affect yeast function when expressed as the sole copy of the essential Rrp40 protein. In contrast, the rrp40-W195R variant, corresponding to EXOSC3-W238R in PCH1b patients, impacts cell growth and RNA exosome function when expressed as the sole copy of Rrp40. The rrp40-W195R protein is unstable, and does not associate efficiently with the RNA exosome in cells that also express wild-type Rrp40. Consistent with these findings in yeast, the levels of mouse EXOSC3 variants are reduced compared to wild-type EXOSC3 in a neuronal cell line. These data suggest that cells possess a mechanism for optimal assembly of functional RNA exosome complex that can discriminate between wild-type and variant exosome subunits. Budding yeast can therefore serve as a useful tool to understand the molecular defects in the RNA exosome caused by PCH1b-associated amino acid substitutions in EXOSC3, and potentially extending to disease-associated substitutions in other exosome subunits.
Luminescence quenching of Sm3+ ions in alkali borotellurite glasses
Authors: Tuyen Vu Phi , Do Phan Van 
Published: October 2016

The dependence of luminescence intensity on Sm\(^{3 + }\) ions concentration in alkali borotellurite (ABTe) glasses has been studied. The quenching of luminescence intensity happens around 0.75 mol% concentration of Sm\(^{3 + }\) ions and it can relate the energy transfer process through cross--relaxation (CR), the CR channels in ABTe: Sm\(^{3 + }\) have been shown. The method of Van Uitert was used to find the dominant interaction mechanism for energy transfer process.
A Model of Bulk Supersymmetry in Warped Spacetime
Authors: Hieu Tran Minh 
Published: October 2016

The Randall-Sundrum solution to the hierarchy problem in the brane-world scenario has made a significant impact on the development of model building.We investigate in this paper a model of supersymmetry in a 5D spacetime with the Randal-Sundrum warped metric.The minimal supersymmetric extension of the standard model (MSSM) superfields propagate in the bulk between the UV and IR branes at separated orbifold fixed points, while the hidden sector in charge of supersymmetry breaking is confined on the UV brane.We derive the 4D effective action from the original 5D action of the underlying theory.The effective 4D Yukawa couplings and all the soft supersymmetry breaking terms are calculated in terms of the 5D theory's coefficients. We comment on the important role of the bulk mass parameter in the relation with the geometrical properties of particles.
Synthesis and Characterization of Ag/PEDOT:PSS Films Used for NH\(_3\) Selective Sensing
Authors: Dinh Nguyen Nang , Long Lam Minh , Thu Hoang Thi , Hoa Huynh tran My , Trung Tran Quang 
Published: October 2016

Nano-Ag/PEDOT-PSS films were prepared by spin-coating technique. SEM surface morphology, Raman spectra and gas sensing of methanol, humidity and NH3 were studied. The obtained results showed that the resistance of Ag/PEDOT:PSS sheets exposed to gases related to the generation of electrons from the gases adsorption that eliminated holes as the major carriers in PEDOT:PSS. For NH3 gas the largest change of the resistance of Ag/PEDOT:PSS was observed. The less sensitivity of humidity and ethanol sensing was explained due to less dedoping reaction between H2O and ethanol vapor with Ag/PEDOT:PSS, respectively. This suggests a potential application of the nano-Ag/PEDOT-PSS sensors for the selective monitoring NH3 gas in environment.
Neuronale Zeroidlipofuszinose bei einem adulten American Staffordshire Terrier
Authors: Nolte Anna , Bello Aimara , Drögemüller Michaela , Leeb Tosso , Brockhaus Eva , Baumgärtner Wolfgang , Wohlsein Peter 
Published: October 2016

ZusammenfassungDer Fall eines weiblichen, 5 Jahre alten American Staffordshire Terriers mit hochgradigen progressiven neurologischen Ausfallserscheinungen, insbesondere in Form von Ataxie und Balanceproblemen, wurde pathomorphologisch aufgearbeitet und genetisch untersucht. In Neuronen unterschiedlicher Lokalisationen des Zentralnervensystems zeigte sich eine Akkumulation von feingranulärem, schwach eosinophilem oder hellbräunlichem Material im Zytoplasma. Zusätzlich bestanden eine hochgradige Degeneration und ein Verlust von Purkinjeund inneren Körnerzellen des Kleinhirns. Das akkumulierte PAS-positive, argyrophile, autofluoreszierende Material wies elektronenmikroskopisch eine lamelläre Struktur auf und wurde als Lipofuszin interpretiert. Eine genetische Analyse bestätigte das Vorliegen einer Variante im ARSG-Gen, das für das lysosomale Enzym Arylsulfatase G kodiert. Der Fallbericht beschreibt eine neuronale Zeroidlipofuszinose bei einem adulten Hund, die Ähnlichkeiten mit der Kufs-Krankheit des Menschen aufweist.
Multiple thorakolumbale partielle laterale Korpektomien bei 17 Hunden
Authors: Münch Maria , Held Karina , Salger Florian , Ziegler Luisa , Böttcher Peter , Flegel Thomas 
Published: October 2016

ZusammenfassungGegenstand und Ziel: Beschreibung der Durchführbarkeit und des Endresultats multipler thorakolumbaler partieller lateraler Korpektomien (TLPLCs) bei Hunden mit vorwiegend ventralen thorakolumbalen Bandscheibenvorfällen. Hintergrund war die in der aktuellen Fachliteratur geäußerte Befürchtung, dieser chirurgische Eingriff zur Dekompression könne eine erhebliche Instabilität der Wirbelsäule zur Folge haben. Material und Methoden: Retrospektive Auswertung der Daten von Hunden mit Bandscheibenvorfällen Hansen Typ I und II, die mit multiplen TLPLCs versorgt wurden. Die präoperative Rückenmarkskompression und die postoperative Dekompression sowie die Morphometrie der Korpektomien wurden anhand von computertomo - graphischen Myelographien ausgewertet. Das neurologische Ergebnis wurde mithilfe wiederholter neurologischer Untersuchungen unter Anwendung eines modifizierten Frankel-Scores und einer Besitzer - befragung beurteilt. Ergebnisse: Siebzehn Hunde mit einer mittleren Körpermasse von 20,3 kg (Spanne: 4,0–49,0 kg) gingen in die Studie ein. Bei 14 Hunden erfolgten zwei TLPLCs, bei zwei Hunden drei und bei einem Hund vier. Die Auswertung der Korpektomiemorphometrie ergab folgende Mittelwerte: Tiefe: 63%, Höhe: 29%, Länge: 25% des Wirbelkörpers. Zwischen zwei benachbarten Korpektomieöffnungen verblieben im Mittel 55% der Wirbelkörperlänge. Bei der Kontrolle 4 Wochen post operationem hatten 6/17 Hunden (35,3%) den gleichen Frankel-Score wie vor der Operation, während 11/17 (64,7%) einen neurologisch verbesserten Score aufwiesen. Nach Angaben der Besitzer zeigten 78,5% der Hunde innerhalb 6 Monaten einen unauffälligen Gang. Die mittlere Überlebenszeit von 16 nachverfolgbaren Hunden betrug 951 Tage. Schlussfolgerung und klinische Relevanz: Multiple thorakolumbale Bandscheibenvorfälle können durch mehrere TLPLCs, sogar an unmittelbar benachbarten Bandscheiben, dekomprimiert werden, ohne dass bei den meisten Hunden mit einer klinisch signifikanten Instabilität der Wirbelsäule zu rechnen ist.
The Challenges of Validating in Precision Medicine: The Case of Excision Repair Cross-Complement Group 1 Diagnostic Testing
Authors: Barsanti-Innes Brianna , Hey Spencer Phillips , Kimmelman Jonathan 
Published: October 2016

Abstract
Personalized medicine relies upon the successful identification and translation of predictive biomarkers. Unfortunately, biomarker development has often fallen short of expectations. To better understand the obstacles to successful biomarker development, we systematically mapped research activities for a biomarker that has been in development for at least 12 years: excision repair cross-complement group 1 protein (ERCC1) as a biomarker for predicting clinical benefit with platinum-based chemotherapy in non-small cell lung cancer. We found that although research activities explored a wide range of approaches to ERCC1 testing, there was little replication or validation of techniques, and design and reporting of results were generally poor. Our analysis points to problems with coordinating and standardizing research in biomarker development. Clinically meaningful progress in personalized medicine will require concerted efforts to address these problems. In the interim, health care providers should be aware of the complexity involved in biomarker development, cautious about their near-term clinical value, and conscious of applying only validated diagnostics in the clinic.
Future Electricity Demand of the Emerging European Countries and the CIS Countries
Authors: Bayramoglu Mehmet Fatih 
Published: October 2016

Nowadays, one of the leading factors used in the evaluation of a country’s economic development is energy consumption. Because of economic growth, demand for energy is also increasing. In this study, the emerging European countries’ (the Czech Republic, Poland, Romania, Turkey) and the CIS countries’ (Kazakhstan, Russia, Ukraine, Uzbekistan) electricity consumption has been forecasted for five years period (2015-2019). In the study, GM(1,1) Rolling Model, which is developed in the framework of Grey System Theory is used as a mathematical model for real-time forecasting. The results of the study show that there will not be a significant change in electricity demand in this two area during the 2015-2109 period.
Improving People’s Lives: For the Public Benefit
Authors: Meehan Nathan 
Published: October 2016

President's column
What is the mission of the Society of Petroleum Engineers (SPE)? Why do we collect, disseminate, and exchange technical knowledge? There are plenty of reasons why such activities are valuable. Our mission statement gives a reason for this activity, namely, for the public benefit.
Mission statements of various professional societies often reflect the need to serve the public in some way. The American Society of Mechanical Engineers’ mission statement includes its purpose “to serve diverse, global communities” and “applying engineering knowledge for improving the quality of life.” The mission of the American Institute of Chemical Engineers is to “provide essential value to our members and partners, advance civil engineering, and serve the public good.” The mission of the National Academy of Engineering is “to advance the well-being of the nation.”
The mission of SPE is:
To collect, disseminate, and exchange technical knowledge concerning the exploration, development and production of oil and gas resources, and related technologies for the public benefit; and to provide opportunities for professionals to enhance their technical and professional competence.
The mission was adopted more than 50 years ago. The statement about providing opportunities for professionals to enhance their technical and professional competence forms the basis of many of the Society’s training and professional development activities. The phrase I have emphasized is occasionally replaced by ellipsis in SPE Powerpoint presentation and not discussed enough. Before we discuss SPE’s role for the public benefit, let us look at engineering’s role.
Engineers are uniquely responsible for the machines, buildings, energy, and technology that surround us and are fundamental to our lives. After the Unconventional Resources Technology Conference in San Antonio, Texas, this year, I revisited the Espada Aqueduct built in 1731, completed in 1745 by Franciscan missionaries to provide water for irrigation. It reminded me of the Roman aqueducts built as early as 300 BC and other feats of engineering that resulted in improved health, sanitation, and productivity in societies. The state of engineering at the time was craft work relying on working knowledge of construction, geometry, and fluid flow principles. This type of engineering dates back to the pyramids.
Modern engineering developed in parallel with the industrial revolution, powered by coal.
2015 SPE Annual Technical Conference and Exhibition: ATCE Looks to Brighter Future Amid Challenging Market
Authors: Boschee Pam , Jacobs Trent , Parshall Joel , Rassenfoss Stephen , Whitfield Stephen , Wilson Adam 
Published: October 2016

Conference review - 2015 Annual Technical Conference and Exhibition
More than 13,500 oil and gas professionals gathered at SPE’s Annual Technical Conference and Exhibition (ATCE) on 28–30 September in Houston, making it the second highest-attended ATCE.
The conference, which focused on the positive potential of the future while addressing the current challenges of the oil and gas market, furthered the exchange of industry knowledge with more than 400 technical papers presented at 46 technical sessions. In addition, 450 companies filled the exhibition floor.
Opening Session
A look ahead on the global energy road map to 2040 prompted a lively discussion among panelists at the opening general session on the first day. No one underestimated the challenges faced by the oil industry in the current climate of low prices, project cutbacks, and layoffs. But the discussion also stressed the resilience of the industry, the continued importance of fossil fuel energy to the world economy, and reassurance that the industry will come through a difficult period and be stronger.
Bernard Looney, chief operating officer of production at BP, noted that even before the drop in oil prices, the company was increasingly aware that costs had “really gotten out of control in our industry, particularly in the last 5 years.” The oil price collapse compounded that challenge.
“Small things, they add up, all the way to very big developments like Mad Dog Stage 2 here in the Gulf of Mexico,” Looney said. Through re-examining the project, BP has lowered the price tag from USD 20 billion to USD 14 billion. “And, quite frankly, the question for the team today is could we do that project for less than USD 10 billion?” he said.
Looking forward, Looney cited the positive role that fossil fuel should have in lifting people from poverty around the globe. At the same time, Looney stressed the need for the world to put a price on carbon. Notwithstanding the challenges of the current economic environment, Looney said, “I’m convinced, and I think we’re convinced, that we’ll get through this. The industry has been here before, and we’re an incredibly adaptive industry.”
Innovation, Collaboration
Incoming 2016 SPE President Nathan Meehan, a senior executive adviser at Baker Hughes, noted that in the 1980s, oil prices were depressed and, during those rough times, many of the technologies that enabled production from unconventional and deepwater reservoirs were developed.
Speaking at the SPE Research and Development Technical Section dinner on the eve of the conference’s opening, Meehan called upon industry professionals to respond to the oil price downturn with a renewed spirit of determination. “You are the ones who will have to come up with the technologies that enable us to solve problems differently than we used to solve them,” he said. “You can do it in today’s price environment. You can come up with these innovations.”
Techbits: SPE Effluent Discharge Management Workshop Addresses Standards and Regulations
Authors: JPT staff _ 
Published: October 2016

Techbits
The SPE Trinidad and Tobago Section recently hosted an Applied Technology Workshop (ATW) on oil and gas effluent discharge management in Port of Spain, Trinidad and Tobago.
The event brought together petroleum and petrochemical industry professionals involved in generating effluent discharges to the receiving environment, regulators, and those involved in the design, construction, operation, and maintenance of treatment systems for effluent discharge.
The goals of the workshop were to
Explore regional and international legislation as applied to effluent discharge in the oil and gas industry and compare with the local regulatory framework in Trinidad and Tobago.
Define the compliance issues of water pollution rules in Trinidad and Tobago specific to the oil and gas industry.
Obtain the industry best practice for effluent treatment and disposal with emphasis on large oil and gas drilling and production operations both onshore and offshore.
Explore the available technology and its applicability to achieve compliance.
There was a consensus that urgent collaborative action is needed among all stakeholders. The path forward received endorsement from the country’s regulators (the Ministry of Energy and Energy Affairs [MEEA] and the Environmental Management Authority [EMA]), operators, and service providers. The areas of focus in the workshop included legislative reform, use of applicable technology, and availability of resources.
Legislative Reform
Participants discussed the Trinidad and Tobago legislation pertaining to effluent discharges. There were also presentations on experiences setting effluent discharge standards in the North Sea using the Convention for the Protection of the Marine Environment of the Northeast Atlantic or OSPAR Convention, for possible use as a framework.
The topics of discussion about legislative reform centered on the following:
Are our current water pollution rules relevant and appropriately framed in the current environment?
The consensus was that there is an opportunity for the review of the current Water Pollution Rules created in 2001 and amended in 2006. For example, there is the need for ambient water-quality standards coupled with discharge standards. Current discharge standards were deemed to be stringent by some presenters compared with other jurisdictions such as OSPAR. OSPAR is using a holistic or risk-based approach in regulating effluent by the use of mixing zones and impact-based ambient water-quality standards vs. technology-based discharge parameters. To develop new ambient water-quality standards, a baseline study must be conducted on the receiving environment of Trinidad and Tobago.
Technology Focus: Gas Production Technology (November 2015)
Authors: Wilson Scott J. 
Published: October 2016

Technology Focus
Only 2 years ago, the conventional wisdom was that oily or liquids-rich plays were the only place to put capital. Gas assets, especially conventional gas, were for true contrarians. While worldwide oil prices have fallen 60% since their 2014 peak, diverse natural gas prices swing between USD 2 and 4/million Btu in the US, USD 8/million Btu in central Europe, and USD 15/million Btu for delivered liquefied natural gas (LNG) in Asia. Depending on your timing and cost structure, gas assets may be a rare highlight in your business in 2015.
Conventional wisdom implies that natural-gas demand will continue to grow, especially in locations where coal is being phased out, nuclear growth has slowed/reversed, and renewables remain a small and intermittent energy source for the foreseeable future.
The underlying fundamentals may tell another story: LNG plants in progress will increase supply by 122 million t/a by 2020, while LNG demand is expected to grow much slower. Even though more LNG import terminals will be completed in the next several years, global regas-facility utilization is only 33% of capacity. Because markets need to balance eventually, will demand grow to soak up the excess supply or will the new volumes be slow to come online?
In free and unregulated markets, the “invisible hand” first described by Adam Smith ultimately guides producers and consumers to a price and quantity that satisfy both parties. Unfortunately, oil and gas markets are far from free and unregulated, so investment time lag, regulations, and politics tend to delay and distort the inevitable balance that must exist in markets. Opinions on the outcome of all these competing factors tend to converge to a group consensus, which is usually just an extrapolation of “more of the same.” In 1986, we were all convinced there would never be another boom and the then-current bust would last forever. Thirty years, and several boom-and-bust cycles later, we are still making straightline projections, even though it is clear that the only thing that stays the same … is change. JPT
Recommended additional reading at OnePetro: www.onepetro.org.
IPTC 18050 Real-Time Blending Optimization in Upstream—Operating on the Edge by Claudia Zuluaga, Sarawak Shell, et al.
SPE 172528 Use of Technology To Enhance Gas Production in Saudi Arabian Carbonate Reservoirs—Key Enablers by Zillur Rahim, Saudi Aramco, et al.
SPE 173606 Post-Fracturing Gas Production Through Shale Capillary Application by A. Hayatdavoudi, University of Louisiana at Lafayette, et al.
A Novel Approach to Evaluate the Risk of Sanding for Optimum Well Completion Design: A Deep-Water Case Study from Southeast Asia
Authors: Younessi A. , Khaksar A. 
Published: October 2016

Abstract
Challenging environments, such as deep-water, require greater effort when designing wells and completion systems. In such cases, hydrocarbon production associated risks must be evaluated from very early stages of field development. Particularly, the risk of sanding should be investigated to select and define the optimum well completion, and if required, the appropriate sand control options. This paper presents a novel approach to predict the onset of sanding by describing a case study from a deep-water gas field in Southeast Asia.
Sanding analysis generally consists of either a numerical or analytical model calibrated against laboratory tests and production histories. Here, both numerical and analytical models are implemented to achieve a robust and reliable prediction in the absence of any production data. For this purpose, the numerical model is prepared and run using a comprehensive material model considering poroelastic-plastic rock behaviour with strain hardening. The rock is modelled from a combination of single-stage triaxial and advanced thick-walled cylinder rock mechanical tests on representative samples from the target reservoirs. A poroelastic analytical model calibrated against the numerical modelling results is then used to conduct sand production predictions with sensitivity analyses for a number of well trajectory scenarios for both cased and perforated, and open-hole completions.
Although the numerical and analytical models follow different assumptions, the sanding prediction results from both models are consistent. Once a reliable validation is obtained, the analytical method can be used with confidence for sand production prediction for future wells through its simplicity and fast realization of various scenarios. The results show that a high risk of sanding exists for both cased and perforated, and open-hole completion systems for the planned deviated wells. Hence, downhole sand exclusion options are deemed to be required for the development wells.
Incorporating analytical poroelastic and numerical poroelastic-plastic sanding evaluations enhanced the reliability of sanding prediction for development wells. This approach is particularly beneficial in the absence of production data at appraisal or early development stages.