bluuebunny/crossref_metadata_2025_split huggingface dataset:
ZOES: galeria a céu aberto, apropriação criativa na escala do bairro
Authors: Edelweiss Roberta Krahe , Paese Celma 
Published: September 2017

O artigo apresenta, a partir da análise do Barrio del Oeste, em Salamanca, a apropriação do território por parte da sociedade civil onde a Associação de Vizinhos tem protagonismo em sua atuação política. Esta apropriação apresenta-se de diversas formas, desde a sua intenção inicial de coletivamente ter força política até as ações contemporâneas de engajamento social e atuações em arte urbana. A participação social e a inserção do exemplo no contexto das cidades criativas apresentam-se como os elementos principais observados no presente artigo. A crítica à falta de identidade nas construções coletivas de habitação em meados do século XX soma-se às ações da Associação de Vizinhos ZOES sob a forma de transformação urbana. O grafite, bem como demais ações como o knitting ou os microjardins são algumas das ações capazes de conferir uma nova e particular identidade ao bairro. Palavras-chave: ZOES, apropriação urbana, cidades criativas
Outcomes of orthopedic surgery in a cohort of 49 patients with X-linked hypophosphatemic rickets (XLHR)
Authors: Gizard A , Rothenbuhler A , Pejin Z , Finidori G , Glorion C , de Billy B , Linglart A , Wicart P 
Published: September 2017

Background
X-linked hypophosphatemic rickets (XLHR) is due to mutations in PHEX leading to unregulated production of FGF23 and hypophosphatemia. XLHR is characterized by leg bowing of variable severity. Phosphate supplements and oral vitamin analogs, partially or, in some cases, fully restore the limb straightness. Surgery is the alternative for severe or residual limb deformities.

Objective
To retrospectively assess the results of surgical limb correction in XLHR (osteotomies and bone alignment except for 3 transient hemiepiphysiodesis).

Methods
We analyzed the incidence of recurrence and post-surgical complications in 49 XLHR patients (29F, 20M) (mean age at diagnosis 6.0 years (± 7.1)).

Results
At first surgery, the mean age was 13.4 years (± 5.0). Recurrence was observed in 14/49 (29%) patients. The number of additional operations significantly decreased with age (2.0 (± 0.9), 1.7 (± 1.0) and 1.2 (± 0.4) in children <11 years, between 11 and 15, and >15 years; P < 0.001). Incidence of recurrence seemed to be lower in patients with good metabolic control of the rickets (25% vs 33%). Complications were observed in 57% of patients.

Conclusion
We report a large series of surgical procedures in XLHR. Our results confirm that phosphate supplements and vitamin D analog therapy is the first line of treatment to correct leg bowing. Surgery before puberty is associated with a high risk of recurrence of the limb deformity. Such procedures should only be recommended, following multidisciplinary discussions, in patients with severe distortion leading to mechanical joint and ligament complications, or for residual deformities once growth plates have fused.
Interpretation of glucocorticoids in neonatal hair: a reflection of intrauterine glucocorticoid regulation?
Authors: Hollanders Jonneke J , van der Voorn Bibian , Kieviet Noera , Dolman Koert M , de Rijke Yolanda B , van den Akker Erica L T , Rotteveel Joost , Honig Adriaan , Finken Martijn J J 
Published: September 2017

Background
Glucocorticoids (GCs) measured in neonatal hair might reflect intrauterine as well as postpartum GC regulation. We aimed to identify factors associated with neonatal hair GC levels in early life, and their correlation with maternal hair GCs.

Methods
In a single-center observational study, mother–infant pairs (n = 107) admitted for >72 h at the maternity ward of a general hospital were included. At birth and an outpatient visit (OPV, n = 72, 44 ± 11 days postpartum), maternal and neonatal hair was analyzed for cortisol and cortisone levels by LC–MS/MS. Data were analyzed regarding: (1) neonatal GC levels postpartum and at the OPV, (2) associations of neonatal GC levels with maternal GC levels and (3) with other perinatal factors.

Results
(1) Neonatal GC levels were >5 times higher than maternal levels, with a decrease in ±50% between birth and the OPV for cortisol. (2) Maternal and neonatal cortisol, but not cortisone, levels were correlated both at postpartum and at the OPV. (3) Gestational age was associated with neonatal GC postpartum (log-transformed β (95% CI): cortisol 0.07 (0.04–0.10); cortisone 0.04 (0.01–0.06)) and at the OPV (cortisol 0.08 (0.04–0.12); cortisone 0.00 (−0.04 to 0.04)), while weaker associations were found between neonatal GCs and other perinatal and maternal factors.

Conclusions
Neonatal hair GCs mainly reflect the third trimester increase in cortisol, which might be caused by the positive feedback loop, a placenta-driven phenomenon, represented by the positive association with GA. Between birth and 1.5 months postpartum, neonatal hair cortisol concentrations decrease sharply, but still appear to reflect both intra- and extrauterine periods.
BclI polymorphism of the glucocorticoid receptor and adrenal crisis in primary adrenal insufficiency
Authors: Zopf Kathrin , Frey Kathrin R , Kienitz Tina , Ventz Manfred , Bauer Britta , Quinkler Marcus 
Published: September 2017

Context
Patients with primary adrenal insufficiency (PAI) or congenital adrenal hyperplasia (CAH) are at a high risk of adrenal crisis (AC). Glucocorticoid sensitivity is at least partially genetically determined by polymorphisms of the glucocorticoid receptor (GR).

Objectives
To determine if a number of intercurrent illnesses and AC are associated with the GR gene polymorphism BclI in patients with PAI and CAH.

Design and patients
This prospective, longitudinal study over 37.7 ± 10.1 months included 47 PAI and 25 CAH patients. During the study period, intercurrent illness episodes and AC were documented.

Results
The study period covered 223 patient years in which 21 AC occurred (9.4 AC/100 pat years). There were no significant differences between BclI polymorphisms (CC (n = 29), CG (n = 34) and GG (n = 9)) regarding BMI, hydrocortisone equivalent daily dose and blood pressure. We did not find a difference in the number of intercurrent illnesses/patient year among BclI polymorphisms (CC (1.5 ± 1.4/pat year), CG (1.2 ± 1.2/pat year) and GG (1.6 ± 2.2/pat year)). The occurrence of AC was not significantly different among the homozygous (GG) genotype (32.5 AC/100 pat years), the CC genotype (6.7 AC/100 pat years) and the CG genotype (4.9 AC/100 pat years). Concomitant hypothyroidism was the highest in the GG genotype group (5/9), compared to others (CC (11/29) and CG (11/34)).

Conclusions
Although sample sizes were relatively small and results should be interpreted with caution, this study suggests that the GR gene polymorphism BclI may not be associated with the frequencies of intercurrent illnesses and AC.
Disparities in the Intensity of End-of-Life Care for Children With Cancer
Authors: Johnston Emily E. , Alvarez Elysia , Saynina Olga , Sanders Lee , Bhatia Smita , Chamberlain Lisa J. 
Published: September 2017

BACKGROUND:
Many adult patients with cancer who know they are dying choose less intense care; additionally, high-intensity care is associated with worse caregiver outcomes. Little is known about intensity of end-of-life care in children with cancer.

METHODS:
By using the California Office of Statewide Health Planning and Development administrative database, we performed a population-based analysis of patients with cancer aged 0 to 21 who died between 2000 and 2011. Rates of and sociodemographic and clinical factors associated with previously-defined end-of-life intensity indicators were determined. The intensity indicators included an intense medical intervention (cardiopulmonary resuscitation, intubation, ICU admission, or hemodialysis) within 30 days of death, intravenous chemotherapy within 14 days of death, and hospital death.

RESULTS:
The 3732 patients were 34% non-Hispanic white, and 41% had hematologic malignancies. The most prevalent intensity indicators were hospital death (63%) and ICU admission (20%). Sixty-five percent had ≥1 intensity indicator, 23% ≥2, and 22% ≥1 intense medical intervention. There was a bimodal association between age and intensity: ages &lt;5 years and 15 to 21 years was associated with intense care. Patients with hematologic malignancies were more likely to have high-intensity end-of-life care, as were patients from underrepresented minorities, those who lived closer to the hospital, those who received care at a nonspecialty center (neither Children’s Oncology Group nor National Cancer Institute Designated Cancer Center), and those receiving care after 2008.

CONCLUSIONS:
Nearly two-thirds of children who died of cancer experienced intense end-of-life care. Further research needs to determine if these rates and disparities are consistent with patient and/or family goals.
Cilostazol enhances atorvastatin-induced vasodilation of female rat aorta during aging
Authors: Nurullahoğlu-Atalık KE , Kutlu S , Solak H , Koca R Özen 
Published: September 2017

Statins have cholesterol-independent effects including an increased vascular nitric oxide activity and are commonly used by patients with cardiovascular disease. Such patients frequently have cardiovascular diseases, which may be treated with cilostazol, a platelet aggregation inhibitor. This study was designed to investigate whether combined use of cilostazol would increase the inhibitory effect of statin on vascular smooth muscle and how maturation would affect these responses. Female Wistar rats, aged 3–4 months (young) and 14–15 months (adult), were sacrificed by cervical dislocation and the thoracic aorta was dissected and cut into 3- to 4-mm-long rings. The rings were mounted under a resting tension of 1 g in a 20-ml organ bath filled with Krebs–Henseleit solution. Rings were precontracted with phenylephrine (10−6 M), and the presence of endothelium was confirmed with acetylcholine (10−6 M). Then, the concentration–response curves were obtained for atorvastatin alone (10−10 to 3 × 10−4 M; control) and in the presence of cilostazol (10−6 M) in young and adult rat aortas. This experimental protocol was also carried out in aorta rings, which had been pretreated with NG-nitro-l-arginine methyl ester (l-NAME, 10−4 M). Atorvastatin induced concentration-dependent relaxations in young and adult rat thoracic aorta rings precontracted with phenylephrine. The pIC50 value of atorvastatin was significantly decreased in adult rat aortas. In addition, pretreatment of aortas with cilostazol enhanced the potency of atorvastatin in both young and adult aortas. Incubation with l-NAME did not completely eliminate the relaxations to atorvastatin in the presence of cilostazol. These results suggest that combined application of cilostazol with atorvastatin was significantly more potent than atorvastatin alone. Combined drug therapy may be efficacious in delaying the occurrence of cardiovascular events.
Reservoirs optimization with dynamic programming
Authors: Phuong Phan Thi Thu , Han Dao Thi Ngoc , Lai Hoang Van , Tri Bui Minh 
Published: September 2017

Differential Evolution (DE) and Dynamic Programming (DP) are important optimal methods in reservoir regulation. In the previous work [1], we presented the outline of DE, and applied it into Pleikrong reservoir, a big one in the Highland of Vietnam for dry season of 2010 year. Continuing from that, in this work, we present the outline of DP and then again, apply it to Pleikrong reservoir; and also apply it to Ialy, the biggest reservoir in Sesan cascade in the Highland of Vietnam; to reach optimal regulation for the maximum power production in the dry season of two years: 2010 and 2012. The results getting from DP are compared to the results by using DE. The results by these two methods have the same trend of releases which is storing the water at the beginning and significantly releasing at the end of the calculation time.
Participatory Air Monitoring in the Midst of Uncertainty: Residents’ Experiences with the Speck Sensor
Authors: Matz Jacob Robert , Wylie Sara , Kriesky Jill 
Published: September 2017

How do participants engage in at-home air monitoring in the midst of uncertain exposures to airborne emissions associated with unconventional natural gas development (UNGD) activities? We investigate residents’ experiences with the “Speck” particulate matter sensor with an emerging environmental health resource center called the Southwest Pennsylvania Environmental Health Project (EHP). In response to the gaps in knowledge about the health impacts of UNGD and the growth citizen science tools, participatory environmental monitoring (PEM) projects have taken off in shale gas communities. Using interview and survey data from residents, advocates, and activists we show that residents use the Speck as: 1) “environmental health thermometers” to make real time decisions based on readings; 2) real-time tools of exposure-validation to immediately validate or invalidate suspicions of exposure; 3) “epistemic objects” or tools manipulated in exploratory ways to understand their efficacy in monitoring UNGD; and 4) passively by those who chose to rarely interact with the monitors and rather waited for overall analysis of results. While PEM’s have been critiqued for potentially passing the burden of monitoring onto communities, our research shows PEM, when connected with research and public health organizations like EHP, can both empower individuals by increasing their perceived and actual agency and build collective knowledge by producing novel scientific findings. The modes of participation identified here each imply individual and community-level outcomes. When connected with an organization like EHP, Speck monitoring enabled participating individual the latitude to develop their own research and make immediate use of the data, while also creating data useful for aggregated scientific analyses that provoke new questions about the health risks associated with UNGD.
Living with Oil and Gas and Practicing Community Conducted Science
Authors: Thomas Deborah 
Published: September 2017

Deborah Thomas is an activist, citizen scientist and Wyoming resident. In this paper she describes experiences gleaned from local efforts to effect positive change and resistance to shale gas development in her own community. Meeting the challenges of development requires collaboration among community members, including farmers, rural residents, city dwellers, non-profits, doctors, scientists, and academics. Creation of and access to scientific information are crucial.
Extraction and Purification of Fucoxanthin from Sargassum sp. as Anti-acne
Authors: Renhoran Mawaddah , Noviendri Dedi , Setyaningsih Iriani , Uju U. 
Published: September 2017

Fucoxanthin is a pigment of a carotenoid group in brown seaweed. Fucoxanthin has high biological activity, therefore, it is suitable for the antibacterial activity. Acne is a disease caused by bacterial activity. The purposes of this study were to obtain fucoxanthin active compounds of Sargassum sp. and to determine antibacterial activity of crude extract and fucoxanthin active fraction as anti-acne compounds at bacteria causing acne. Extraction of fucoxanthin used maceration method and its purification was carried out by silica gel column method. Antibacterial activity test used disk diffusion method. The yield of crude extraction and yield of active fraction of Sargassum sp. were 0.54% and 0.13% respectively. Fucoxanthin active fraction was identified at 0.53 Rf value. The total content of fucoxanthin was 0.47 mg/g. The functional groups of fucoxanthin active fraction consisted of alcohols, alkanes, methyl, alkenes, esters and aromatic alkenes. Fucoxanthin active fraction had anti-acne activity at 125, 250, 500 and 1,000 ug/disk against of Propionibacterium acnes and at 500 and 1,000 ug/disk against of Staphylococcus aureus.<br /><br />
Cloning and Over-expression of xynB Gene of Bacillus subtilis subsp. spizizenii W23 into Escherichia coli Origami Host Cells
Authors: Wahjudi Mariana , . Catherina , Wangunhardjo Nita Marcelia , Suryadjaja Ernest , Daniel Xavier 
Published: September 2017

<p class="Els-Abstract-text">The <em>xyn</em>B gene of <em>Bacillus</em><em> subtilis</em> subsp. spizizenii W23 is predicted to encode a xylan 1,4-beta-xylosidase. Application of XynB enzymes in industries is wide. Production of this enzyme in its host cells is naturally restricted by repression process. It will give certain beneficial to over-expressed the enzymes in other host-cells under inducing promoter. This study aimed to clone the <em>xyn</em>B gene from <em>Bacillus</em><em> subtilis</em> subsp. spizizenii W23, to pMMB67EH plasmid, and to over-express the <em>xyn</em>B gene in <em>Escherichia coli </em>Origami as host cells. The <em>x</em><em>yn</em>B gene was successfully amplified by polymerase chain reaction (PCR) technique using a pair of primers flanking the gene sequence and chromosomal DNA of the W23 strain as a template. The <em>xyn</em>B gene inserted in recombinant plasmid was confirmed by PCR detection using primers pair’s specific for <em>xyn</em>B gene and for the vector, then continued by restriction analyses. The result showed that transformants clone 9 and 10 bear the recombinant pMMB-<em>xyn</em>B plasmid. The xylanase activity of <em>xyn</em>B gene in <em>Escherichia coli</em> Origami clone 10 was detected by sodium-dodecyl-sulfate polyacrylamide gel analyses and with addition of isopropyl-β-D-thio-galactoside (IPTG) as an inducer. The protein seem to be over-expressed as intra- and extra-cellular protein detected on SDS-PAGE gel. Result from xylan degrading activity on Luria-Bertani-xylan-IPTG plate with addition of Congo Red, showed that the cells with pMMB-<em>xyn</em>B recombinant plasmid have clear zone around the colonies while the transformant bearing an empty plasmid showed no clear zone. It could be concluded that the <em>xyn</em>B gene of <em>Bacillus subtilis</em> subsp.spizizenii W23 has been successfully been cloned on pMMB67EH plasmid and over-expressed in the <em>Escherichia coli</em> Origami cells as intra- and extra-cellular protein, as observed on SDS-PAGE gel analysis. The protein has activity on xylan degradation.</p>
Composting of Corn By-Product using EM4 and Microorganism Azotobacter sp. as Composting Organism
Authors: Hendriani Nuniek , Juliastuti Sri Rachmania , Masetya Hamida Nuur , Saputra Imam Tianto Aditiyas 
Published: September 2017

<p>Nowadays the organic compost is very important for farmers because of its environmentally friendly character. However, the production technology of organic compost is not well-known yet for the farmers. This study aimed to utilize corn by-product compost as fertilizer for plants growth. Composting process was accelerated by addition of composting organism called as effective microorganism (EM4) and <em>Azotobacter</em>. Their composition were EM4:<em>Azotobacter</em> 1:1 ; 1:3, EM4 alone, <em>Azotobacter</em> alone and without addition of composting microorganism. The composting process was conducted in a composter for 15 d and mixed three times per day. The process should be carried out under controlled aerobic conditions. The observed parameters were carbon (C), nitrogen (N), phosphor (P), and potassium (K) content. The parameters was measured before and after composting process. The resulted compost were applied to the growing corns, chilis, and tomatoes as fertilizer. The result showed that the best compost was obtained on 3:1 composition of EM4 : <em>Azotobacter</em>. This composition was able to reduce 0.74 % carbon content, and increase 151.46 %, 147.9 %, and 238.42 % of N, P, K content respectively. Moreover this particular compost was able to bring 3.75 mm corn stem and 1.0 mm corn leaf growth per day, lead to harvesting of two tomatoes and eight chilie</p>
Sutureless Compression Anastomoses Formation with Use of TiNi Device on the Small Gut
Authors: Dambaev G.Ts. , Gunther V.E. , Fatushina O.A. , Avdoshina Ye.A. , Solovyov M.M. , Fatushina A.M. , Iablonchuc D.A. 
Published: September 2017

A new device made of nickelid titanium and a way of formation of a sutureless compression anastomosis on the small bowel were developed with the purpose of creating a compression interintestinal anastomosis on the small bowel without the manual portion of seams. 28 sutureless compression anastomosis on the small bowel are created during the experiment. They include 10 «side-to–side» anastomoses, 10 «end-to-end»anastomoses and 8 «end-to-side» anastomoses. Mechanical and biological durability of anastomoses, terms of compression devices failure, primary permeability of anastomoses, morphogenesis of a compression seam are studied. No complications connected with the use of the compression device were noted. During the experiment it is proved that all sutureless compression anastomoses created by means of the nickelid titanium device are mechanically and is biologically tight. By the ninth day all the dogs had no compression devices in their abdominal cavities. The histological researches show that the process of neogenesis goes with the minimal symptoms of sclerosis and leads to the full adaptation of all small bowel layers. The new way of the formation of a sutureless compression anastomosis on the small bowel allowed to create a stronger and more reliable anastomosis and thereby to prevent the development of typical complications and to receive more favorable remote results.
Biometrics of Jaw Models Analysis in Treating Tooth Position Anomalies with the Use of Orthodontic Shape Memory Apparatus
Authors: Turetskova I.A. , Zvigintsev M.A. , Gunther V.E. 
Published: September 2017

The paper presents the results of research in the field of orthodontic treatment of patients with the use of conventional bracket system methods as well as with the orthodontic thread and hollow tube made of superelastic nickelid titanium (TiNi) alloy, the method of measurement of plaster jaw models introduced by L. Persin. The study reveals the advantages of our newly developed apparatus for orthodontic tooth movement in the transverse and sagittal directions.
Environmental and Technological Aspects of Converter Slag Utilization in Sintering and Blast-Furnace Production
Authors: Spirin N.A. , Polinov` A.A. , Pavlov A.V. , Onorin O.P. , Logachev G.N. 
Published: September 2017

The paper presents calculation results for predictive conditions of blast furnace operation with the use of converter slag in the iron ore portion of the blast furnace burden. It shows that addition of converter slag in the sinter and blast-furnace burden without correction of the operating conditions is not reasonable as it significantly worsens parameters of blast furnace operation. Long-term operation of blast furnaces with addition of converter slag in the burden will be accompanied by gradual accumulation of phosphorus in metal and will lead to increasing problems regarding phosphorus removal at the converter production stage. The use of converter slag makes it possible to increase the consumption of non-fluxed pellets without changing the sinter basicity and improve parameters of blast-furnace smelting. The problem of efficient and continuous use of converter slag in blast furnaces can be solved by the complex analysis of this problem: evaluation of economic feasibility of its use as a fluxing agent; feasibility study of this issue for the “blast-furnace production – converter production” complex; analysis of environmental problems during operation at the factory and in the region.