bluuebunny/crossref_metadata_2025_split huggingface dataset:
Purely endoscopic pterional extradural approach: A novel technique for repair of cerebrospinal fluid rhinorrhea
Authors: Sinha Ajit Kumar , Goyal Sumit 
Published: February 2016

ABSTRACT
Study Design: Retrospective descriptive study of an innovative surgical technique. Objective: To assess the feasibility and success of repair of transfrontal sinus cerebrospinal fluid (CSF) rhinorrhea through pterional transcranial extradural approach using endoscope. Summary of Background Data: Repair of CSF rhinorrhea has seen advancement with the evolution of endoscopic transnasal techniques. However, leaks from defect in the posterior wall of frontal sinus still remain a challenge for the skull base surgeons and requires conventional craniotomy more often. We describe a novel technique to repair these leaks by purely endoscopic pterional extradural (PEPE) approach thereby avoiding complications associated with conventional craniotomy and endoscopic transnasal approaches. Materials and Methods: Thirty-five patients with traumatic CSF rhinorrhea from the posterior wall of frontal sinus underwent repair with the present technique. They were followed up for 6–18 months and were evaluated for feasibility of procedure, recurrence of leak, and occurrence of the fresh neurological deficit. Results: Thirty-five patients underwent CSF rhinorrhea repair using the above technique. The procedure was accomplished in all patients without any intraoperative complications. There was no requirement of blood transfusion in any case. All patients had a cessation of CSF leak in the postoperative period, and there was no recurrence. There was no evidence of frontal lobe retraction injury in any of these patients, and no fresh neurological deficit was observed. Conclusion: This PEPE approach to repair CSF leak through the posterior wall of the frontal sinus is a novel technique in which we can avoid disadvantages associated with both conventional craniotomy as well as transnasal endoscopic approaches.
Intrinsic brainstem schwannoma – A rare clinical entity and a histological enigma
Authors: Sharma Anil Kumar , Savardekar Amey R. , Nandeesh B. N. , Arivazhagan A. , Rao Malla Bhaskar 
Published: February 2016

ABSTRACTIntraparenchymal schwannomas arising in the brainstem are very rare, and only eight cases have been reported in literature till now. We report an intraparenchymal brainstem schwannoma presenting with the classical clinical presentation of an intrinsic brainstem lesion, and discuss its clinicoradiological characteristics and histological origins. We highlight the importance of an intraoperative frozen section diagnosis in such cases. Intraoperative tissue diagnosis significantly may alter the surgical strategy, which should be aimed at near total intracapsular decompression of the schwannoma.
Finite Determinacy and Stability of Flatness of Analytic Mappings
Authors: Adamus Janusz , Seyedinejad Hadi 
Published: February 2016

Abstract
It is proved that flatness of an analytic mapping germ from a complete
intersection is determined by its sufficiently high jet. As a consequence, one
obtains finite determinacy of complete intersections. It is also shown that
flatness and openness are stable under deformations.
The common marmoset (&lt;i&gt;Callithrix jacchus&lt;/i&gt;): a relevant preclinical model of human (auto)immune-mediated inflammatory disease of the brain
Authors: 't Hart Bert A. , Dunham Jordon , Jagessar S. Anwar , Kap Yolanda S. 
Published: February 2016

Abstract. The increasing prevalence of chronic autoimmune-mediated inflammatory disorders (AIMIDs) in aging human populations creates a high unmet need for safe and effective medications. However, thus far the translation of pathogenic concepts developed in animal models into effective treatments for the patient has been notoriously difficult. The main reason is that currently used mouse-based animal models for the pipeline selection of promising new treatments were insufficiently predictive for clinical success. Regarding the high immunological similarity between human and non-human primates (NHPs), AIMID models in NHPs can help to bridge the translational gap between rodent and man. Here we will review the preclinical relevance of the experimental autoimmune encephalomyelitis (EAE) model in common marmosets (Callithrix jacchus), a small-bodied neotropical primate. EAE is a generic AIMID model projected on the human autoimmune neuro-inflammatory disease multiple sclerosis (MS).
The Section 527 Obstacle to Meaningful Section 501(c)(4) Regulation
Authors: Aprill Ellen P. 
Published: February 2016

As is well known, on May 10, 2013, at a session of the American Bar Association Tax Section meeting in Washington, DC, Lois Lerner, at the time the director of the Exempt Organization Division of the Internal Revenue Service, apologized for IRS mishandling of applications by Tea Party groups for exemption as social welfare groups under § 501(c)(4) of the Code. A few days later, the Department of the Treasury Inspector General released a report (TIGTA Report) concluding that the “IRS used inappropriate criteria that identified for review Tea Party and other organizations applying for tax-exempt status based upon their names or policy positions instead of indications of potential political campaign intervention
The Relationship between Training and Employee Performance: The Case of Mutare City Council, Zimbabwe
Authors: Dabale Wehnam Peter , Jagero Nelson , Nyauchi Mentline 
Published: February 2016

The Success of failure of an organization depends on the quality of its human resources and training being an integral part of the strategy to integrate human resources management with an organizations business strategy, coming at the age where employees are beginning to realize that employers have the potential to be much more dynamic and beneficial to the organization. Hence, this study was aimed to determine the relationship between training and employee performance in Mutare City Council, Zimbabwe. Correlational research design was used in this study, with an attempt describe and measure the degree of association between performance and training. A total of one hundred and thirty two (132) respondents (91 males and 41 females) were selected from the employees (population), purposive sampling technique and structured questionnaire were used in data collection. Data was analyzed using quantitative techniques, including inferential statistics. It was established that there was strong positive relationship between training and performance of employees. It was recommended that all stakeholders, be involved in one way or the other in training to enhance employee knowledge, skills, ability, competencies and behaviour.
The Relationship between Manager, s Decision Making Styles and Teachers Empowerment in Saveh Primary School
Authors: Hosseinzadeh Davoud , Davoudi Amir Hosain Mohammad , Jokar Khadijeh 
Published: February 2016

The present research was conducted to find out the relationship between manager, s decision making styles and teachers empowerment in primary schools of Saveh city. Research methodology of the study from the perspective of data collection in descriptive and correlation and from the perspective of purpose، is a practical one. The population of the study consisted of all the teachers of Saveh primary school. Based on Morgan, s Table، a sample size of 211 persons was determined and the samples were randomly selected through relative stratified method. Data collection tools were two standard questionnaires of decision making style Scott & Bruce، consisting of 25 items and psychological empowerment Spritzer questionnaires containing 20 items in five –point Likert scale. The content validation of each of the two questionnaires were confirmed by the specialists and their reliability calculating Cronbach s coefficient alpha were respectively 0.75 and 0.88. The datacollected through descriptive and inferential statistics، like Kolmogorow-Smirnov test، pearson correlation coefficient، regression and step by step analysis were analyzed through the statistical software SPSS. The results of the study reveal that there is relationship between manager, s decision making styles and teachers empowerment. in such a way among the predictive variable dimensions،only “ rational and avoidant Decision Making style” were on the model.Considering the results of the study، there is a significant positive relationship between rational decision making style and empowerment. There are significant negative relationship between avoidant and spontaneous decision making styles and empowerment. There aren’t relationship between intuitive and avoidant decision making styles and empowerment.
Era de Cambios Comprender la postmodernidad
Authors: Rodríguez Leonarda Andino 
Published: February 2016

En el presente artículo se hace un esbozo de la postmodernidad, vista desde diferentes autores; un tema controversial, generador de debate y de grandes cambios en el orden mundial. En la postmodernidad, la educación ha entrado en crisis y aún no ha encontrado la ruta para hacerle frente a las demandas de una era en la que, la escuela es moderna pero los alumnos son postmodernos UNAH INNOV@ No.2 2013: 30-35
A finalidade moral do fazer sociológico: sobre os sentidos do conceito de normal em Émile Durkheim
Authors: Hertzog Lucas , Weiss Raquel Andrade 
Published: February 2016

<p>Nosso propósito neste artigo consiste em avaliar criticamente o conceito de normalidade na teoria de Émile Durkheim para além do desenvolvimento realizado em As regras do método sociológico. Esperamos explicitar que o conceito de “normal” é um assunto central na teoria do autor, e traz consigo um inesperado potencial crítico, na medida em que sustenta a possibilidade de uma finalidade prática para a ciência, fornece critérios para se conceber a ação e a mudança social e, especialmente, permite avaliar de forma crítica as condições de possibilidade de solidariedade social para além da ideia de um mero consenso tácito. </p>
ЕФЕКТИ ПРИВАТИЗАЦИЈЕ У СРБИЈИ
Authors: Jovović Marina , Maksimović Danijela , Marčetić Marija 
Published: February 2016

Приватизација представља кључну карику у процесу спровођења транзиције. Приватизација у Србији траје четврт века. Многи унутрашњи и спољни фактори су утицали на успоравање овог процеса.Процес приватизације у Србији прошао је кроз различите фазе. Са окончањем приватизације опада прилив страних директних инвестиција. У раду се анализирају изабрани концепти приватизације. Акценат је стављен на постигнуте резултате приватизације у Србији.
Virtual vibration test rig for fatigue analysis of dozer push arms
Authors: Hou Lei , Li Weibin , Gu Wenyan , Sun Zizheng , Zhu Xiangqian , Choi Jin‐Hwan 
Published: September 2024

AbstractTo obtain accurate fatigue life results for construction machinery components, acquiring load spectra is crucial, as their authenticity and validity directly determine the precision of the analysis. In working conditions, component attitudes change continuously, but they remain static on the vibration test rig (VTR), so the acquired target signals should match with the actual component attitudes in the driving signal generation. This paper proposes an efficient and economical simulation‐based virtual VTR for fatigue analysis of dozers. First, the relationship between the push arm rotation angle and the cylinder stroke is established, since the cylinder strokes can be measured easily in data acquisition experiments. Second, load decomposition is used to determine the attitude relationship between virtual VTR conditions and actual conditions, and target signals are calculated based on this attitude relationship and measured data. According to the system's frequency response function, the driving signals are iterated until the system's response signals converge with the target signals. Finally, the iteratively obtained load spectra are utilized for fatigue life analysis. The results show that the virtual VTR can effectively and accurately obtain the results of fatigue analysis and has engineering application significance.
Craniospinal irradiation and/or intraventricular radioimmunotherapy after high‐dose chemotherapy and autologous stem cell rescue in patients with CNS retinoblastoma—Safety and outcomes
Authors: Sait Sameer Farouk , Kernan Nancy A. , Klein Elizabeth , Spitzer Barbara , Levy Carolyn Fein , Fish Jonathan , Yildirim Onur , Haque Sofia , Donzelli Maria , Bernot Mauricio Rendon , Abramson David H. , Francis Jasmine H. , Khakoo Yasmin , Karajannis Matthias , Sands Stephen , Pandit‐Taskar Neeta , Wolden Suzanne , Kramer Kim , Dunkel Ira J. 
Published: September 2024

AbstractBackgroundThe prognosis for patients with central nervous system (CNS) retinoblastoma (RB) (trilateral or stage 4b metastatic RB) treated with high‐dose chemotherapy and autologous stem cell transplant (HDC‐ASCT) remains poor. The impact of irradiation when administered as part of upfront therapy post HDC‐ASCT on treatment outcomes and survival is unknown.MethodsWe performed a retrospective review of all patients with CNS RB (seven stage 4b, eight trilateral, one pineal lesion belonging to methylation group RB) who underwent induction chemotherapy with an intent to proceed to HDC‐ASCT at two institutions.ResultsTwelve of 16 patients (n = 75%) achieved an objective response to induction chemotherapy, while four patients had progressive/refractory disease; two patients responded to subsequent therapy and proceeded to ASCT, and two patients did not. Seven of 14 patients who underwent HDC‐ASCT, received radiotherapy as part of upfront therapy post HDC‐ASCT in the form of craniospinal irradiation (CSI) (n = 3), intraventricular radioimmunotherapy (n = 3), or both CSI and intraventricular radioimmunotherapy (n = 1). The Kaplan–Meier estimate of overall survival for these patients was 62.5% at 5 years; no patients developed second malignant neoplasms within the radiation fields. For the seven patients who did not receive radiotherapy, the overall survival was 28.6% at 5 years.ConclusionsCSI (23.4 Gy) alone or in conjunction with intraventricular RIT may have clinical utility in eliminating persistent MRD post HDC‐ASCT, contributing to improved disease‐free survival in patients with CNS RB. This treatment strategy merits evaluation in a prospective, multicenter clinical trial for patients with CNS metastatic RB.
A Unified Contrastive Loss for Self-training
Authors: Gauffre Aurélien , Horvat Julien , Amini Massih-Reza 
Published: September 2024

AbstractSelf-training methods have proven to be effective in exploiting abundant unlabeled data in semi-supervised learning, particularly when labeled data is scarce. While many of these approaches rely on a cross-entropy loss function (CE), recent advances have shown that the supervised contrastive loss function (SupCon) can be more effective. Additionally, unsupervised contrastive learning approaches have also been shown to capture high quality data representations in the unsupervised setting. To benefit from these advantages in a semi-supervised setting, we propose a general framework to enhance self-training methods, which replaces all instances of CE losses with a unique contrastive loss. By using class prototypes, which are a set of class-wise trainable parameters, we recover the probability distributions of the CE setting and show a theoretical equivalence with it. Our framework, when applied to popular self-training methods, results in significant performance improvements across three different datasets with a limited number of labeled data. Additionally, we demonstrate further improvements in convergence speed, transfer ability, and hyperparameter stability. The code is available at https://github.com/AurelienGauffre/semisupcon/.
LLM-Assisted Optimization of Waiting Time in Business Processes: A Prompting Method
Authors: Lashkevich Katsiaryna , Milani Fredrik , Avramenko Maksym , Dumas Marlon 
Published: September 2024

AbstractWaiting is a waste in business processes, adversely affecting performance metrics such as cycle time or on-time delivery. Process mining techniques allow business users to analyze waiting times and their causes based on data extracted from enterprise systems. However, process mining techniques, per se, do not assist users in identifying redesign options to optimize business processes, e.g. to reduce waiting time. Recent studies suggest that Large Language Models (LLMs) may aid business users in various process analysis tasks, particularly in conjunction with process mining techniques. This paper studies how to use LLMs to assist business users in analyzing and redesigning business processes to optimize waiting time. The study compares two methods to prompt an LLM to recommend redesign options to reduce waiting times: (1) a baseline (“zero-shot”) method involving a minimalistic prompt; and (2) an enhanced method where the prompt includes descriptions of redesign patterns that may lead to redesigned processes with lower waiting times. To compare these methods, we conduct a user evaluation that combines semi-structured interviews with a survey involving process analysts. The analysts compare the recommended redesigns in terms of desirable properties of recommendation systems, such as relevance, usefulness, and diversity of the recommended redesigns. The results suggest that the enhanced prompting method yields more relevant and actionable redesign options. In contrast, the baseline produces high-level recommendations more suited for managerial decision-making.
Navigating the landscape of e-commerce: thematic clusters, intellectual turning points, and burst patterns in online reputation management
Authors: Lopez-Lopez David , Plaza-Navas Miquel Angel , Torres-Pruñonosa Jose , Martinez Luis F. 
Published: September 2024

Abstract
Recognizing the challenges identified in the vast literature exploring the intellectual landscape of Online Reputation Management (ORM) in the realm of e-commerce, this study performs a quantitative bibliometric analysis, specifically a co-citation analysis using CiteSpace software, to find thematic clusters in a sample of 1136 papers containing 48,385 cited references. This is the first co-citation analysis of ORM literature that cluster the intellectual structure and identifies both the intellectual turning points and burst papers. The results reveal 14 distinct co-citation clusters, each representing a unique thematic structure. An in-depth analysis further characterizes the clusters, ranging from the impact of online reputation on the hospitality industry to frameworks explaining trust formation in e-commerce. Additionally, the study identifies intellectual turning points by assessing betweenness centrality, highlighting four seminal papers that have strongly influenced the field. Furthermore, burst detection analysis uncovers the temporal dynamics of research trends, showcasing the enduring influence of certain clusters and the transient nature of burst patterns. The novelty and importance of the results from the detailed burst detection analysis lie in identifying a significant evolution in research focus over time. Initially, research was concentrated on foundational studies and understanding customer behavior. It then shifted towards practical applications in specific industries, particularly in hospitality and online reviews. In recent years, the emphasis has been on integrating ORM into broader business strategies, especially within e-commerce and the collaborative economy. This research not only contributes to a deeper understanding of ORM, but also serves as a valuable guide for researchers, practitioners, and policymakers in the evolving landscape of online reputation in e-commerce.
From cortisol-producing adrenal adenoma to atrial myxoma, through nivolumab-induced hypophysitis: a complicated case report of Carney Complex
Authors: Di Gioia Ludovico , Dambrosio Giovanni , Cignarelli Angelo , Natalicchio Annalisa , Perrini Sebastio , Laviola Luigi , Giorgino Francesco , Sorice Gian Pio 
Published: September 2024

Abstract
Purpose
Carney complex (CNC) is a rare, autosomal dominant syndrome, most commonly caused by PRKAR1A gene mutations and characterized by pigmented skin and mucosal changes with multiple endocrine and non-endocrine tumours. This case report highlights the diagnostic challenges associated with CNC in a patient with multiple neoplasms and a complex medical history, including cortisol-producing adrenal adenoma, breast cancer, melanoma, and atrial myxoma.

Methods
We report the case of a 41-year-old woman with a medical history of left adrenalectomy for cortisol producing adenoma (2005) with no sign of adrenal insufficiency at follow-up, right mastectomy for BRCA1/2 negative carcinoma (2013) and left parotid BRAF-V600E wild-type melanoma (2019), treated with nivolumab adjuvant therapy. In August 2019, following the fifth nivolumab administration, the patient developed central hypocortisolism due to iatrogenic hypophysitis, confirmed by brain MRI and properly treated with oral hydrocortisone. Nivolumab was discontinued due to the patient’s decision. In October 2020 and April 2021, the patient had ischaemic strokes, requiring systemic thrombolysis. Echocardiographic examination then revealed a left atrial mass, with histological finding of myxoma.

Results
Given the rarity of this neoplasm and the suspicion of a syndromic disorder, a genetic evaluation was conducted, which confirmed a PRKAR1A gene mutation and the diagnosis of Carney complex.

Conclusion
This case illustrates the diagnostic challenges in CNC, especially in patients with multiple tumourous manifestations and a wide spectrum of life-threatening clinical presentations. It underscores the importance of a multidisciplinary approach to diagnose and manage rare diseases, improving patient outcomes through timely genetic testing and coordinated care.
Hematological involvement in nephropathic cystinosis: new insights
Authors: El-Ghamrawy Mona , Soliman Neveen A. 
Published: September 2024

AbstractNephropathic cystinosis (NC) is a rare autosomal recessive lysosomal storage disease characterized by defective lysosomal efflux of cystine due to variations in the CTNS gene encoding the lysosomal cystine transporter, cystinosin. This leads to pathological crystal accumulation in almost all tissues and organs in the body, affecting their functions. NC primarily affects the kidneys followed by a cascade of extrarenal organ involvement later in life. There are few reports of hematological complications as anemia or cytopenias; nevertheless, most of the reported data have been derived from case reports or small case series. Anemia/cytopenias in NC can be multifactorial in origin. Early identification and timely management of these alterations are critical to better growth, improved outcome, and quality of life of NC patients. Early diagnosis of NC, early initiation of both supportive and definitive cystine-depleting treatment, and adherence to therapy remain the mainstay for disease control and prevention of progression of some extrarenal complications. We hereby review hematological findings in NC, discuss the underlying contributing factors, suggest work-up, and highlight treatment options for hematological complications in NC patients. Given the multisystem nature of NC, we recommend integrated NC care approach with involvement of hematologist into its multidisciplinary team.