bluuebunny/crossref_metadata_2025_split huggingface dataset:
Weeding Out the Justification for Marijuana Treatment in Patients with Developmental and Behavioral Conditions
Authors: Nelson Theodora , Liu Yi Hui , Bagot Kara S. , Stein Martin T. 
Published: June 2017

CASE: Alex is a 13-year-old adolescent with high-functioning autism spectrum disorder, attention-deficit/hyperactivity disorder (ADHD)-combined type, anxiety, and depression. He has been resistant to engaging in therapy and treatment with various medications has been unsuccessful. Alex's parents are concerned about his anxiety, isolation, oppositional behaviors, academic underachievement, truancy, and substance use. A recent altercation with his stepfather led to a police intervention and a brief removal of Alex from the home. Alex previously used alcohol and other drugs; at present, he reports that his current drug use consists of frequently smoking pot. Alex states that he uses marijuana to relieve his anxiety and does not understand why this is problematic as marijuana is now legal in his state.
Kevin is a 24-year-old adult man with diagnoses of autism spectrum disorder, mild intellectual disability, and schizoaffective disorder. He has a long history of challenging and problematic behaviors including aggression toward self and others, property destruction, inappropriate sexual behaviors, elopement, emotional outbursts, anxiety, and suicidal ideation. Past diagnoses include bipolar affective disorder, depression, and intermittent explosive disorder. Kevin is notably obese and somnolent. His current medications include 8 psychotropic medications, 3 antiallergy medications, levothyroxine, and a fish oil supplement. His father reports that medications have gradually been added and dosages increased over time. Two weeks ago, his new psychiatrist initiated a trial of medical marijuana. His father hopes that the marijuana will allow Kevin's other medications to be decreased or discontinued.
Linda is an 11-year-old girl with high-functioning autism spectrum disorder, anxiety, and ADHD-inattentive subtype. Anxiety has been her most impairing condition, and Linda has been responding well to a treatment with cognitive behavioral therapy and a selective serotonin reuptake inhibitor. She is also working with her therapist on strategies to address her symptoms of ADHD. Linda has had no side effects from her medication and she and her family have been pleased with her progress. At a follow-up appointment, her mother brings an article from the lay press authored by a parent who claims that marijuana “saved” her autistic son. Linda's mother asks if marijuana should be considered for her daughter.
Visual and Motor Recovery After “Cognitive Therapeutic Exercises” in Cortical Blindness: A Case Study
Authors: De Patre Daniele , Van de Winckel Ann , Panté Franca , Rizzello Carla , Zernitz Marina , Mansour Mariam , Zordan Lara , Zeffiro Thomas A. , O'Connor Erin E. , Bisson Teresa , Lupi Andrea , Perfetti Carlo 
Published: June 2017

Background and Purpose:Spontaneous visual recovery is rare after cortical blindness. While visual rehabilitation may improve performance, no visual therapy has been widely adopted, as clinical outcomes are variable and rarely translate into improvements in activities of daily living (ADLs). We explored the potential value of a novel rehabilitation approach “cognitive therapeutic exercises” for cortical blindness.Case Description:The subject of this case study was 48-year-old woman with cortical blindness and tetraplegia after cardiac arrest. Prior to the intervention, she was dependent in ADLs and poorly distinguished shapes and colors after 19 months of standard visual and motor rehabilitation. Computed tomographic images soon after symptom onset demonstrated acute infarcts in both occipital cortices.Intervention:The subject underwent 8 months of intensive rehabilitation with “cognitive therapeutic exercises” consisting of discrimination exercises correlating sensory and visual information.Outcomes:Visual fields increased; object recognition improved; it became possible to watch television; voluntary arm movements improved in accuracy and smoothness; walking improved; and ADL independence and self-reliance increased. Subtraction of neuroimaging acquired before and after rehabilitation showed that focal glucose metabolism increases bilaterally in the occipital poles.Discussion:This study demonstrates feasibility of “cognitive therapeutic exercises” in an individual with cortical blindness, who experienced impressive visual and sensorimotor recovery, with marked ADL improvement, more than 2 years after ischemic cortical damage.Video Abstract availablefor additional insights from the authors (see Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A173).
Adverse Experiences in Childhood and Sexually Transmitted Infection Risk From Adolescence Into Adulthood
Authors: London Stephanie , Quinn Kelly , Scheidell Joy D. , Frueh B. Christopher , Khan Maria R. 
Published: June 2017

Background
Childhood maltreatment, particularly sexual abuse, has been found to be associated with sexual risk behaviors later in life. We aimed to evaluate associations between a broad range of childhood traumas and sexual risk behaviors from adolescence into adulthood.

Methods
Using data from Waves I, III and IV of the National Longitudinal Study of Adolescent to Adult Health (Add Health), we used logistic regression to estimate the unadjusted odds ratio (OR) and adjusted OR (AOR) for associations between 9 childhood traumas and a cumulative trauma score and three sexual risk outcomes (multiple partnerships, sex trade involvement, and sexually transmitted infection [STI]) in adolescence, young adulthood, and adulthood. We also examined modification of these associations by gender.

Results
Associations between cumulative trauma score and sexual risk outcomes existed at all waves, though were strongest during adolescence. Dose-response–like relationships were observed during at least 1 wave of the study for each outcome. Violence exposures were strong independent correlates of adolescent sexual risk outcomes. Parental binge drinking was the only trauma associated with biologically confirmed infection in young adulthood (AOR, 1.46; 95% confidence interval [CI], 1.01–2.11), whereas parental incarceration was the trauma most strongly associated with self-reported STI in adulthood (AOR, 1.70; 95% CI, 1.11–2.58). A strong connection was also found between sexual abuse and sex trade in the young adulthood period (AOR, 2.17; 95% CI, 1.43–2.49).

Conclusions
A broad range of traumas are independent correlates of sex risk behavior and STI, with increasing trauma level linked to increasing odds of sexual risk outcomes. The results underscore the need to consider trauma history in STI screening and prevention strategies.
Effects of Portal Hypertension on Gadoxetic Acid–Enhanced Liver Magnetic Resonance
Authors: Asenbaum Ulrika , Ba-Ssalamah Ahmed , Mandorfer Mattias , Nolz Richard , Furtner Julia , Reiberger Thomas , Ferlitsch Arnulf , Kaczirek Klaus , Trauner Michael , Peck-Radosavljevic Markus , Wibmer Andreas G. 
Published: June 2017

Objective
The aim of this study was to investigate the impact of portal hypertension (PH) on gadoxetic acid–enhanced liver magnetic resonance imaging (MRI) and assess diagnostic and prognostic implications in comparison to established imaging features of PH.

Materials and Methods
Institutional review board–approved retrospective study of 178 patients (142 men; median age, 59.4 years) with chronic liver disease undergoing MRI and hepatic venous pressure gradient (HVPG) measurement between January 2008 and April 2015. Magnetic resonance imaging was assessed for established features of PH (splenic and portal vein diameters, portosystemic collaterals, ascites) and for features on 20 minutes delayed T1-weighted gadoxetic acid–enhanced MRI, that is, relative liver enhancement (RLE), biliary contrast excretion, or portal vein hyperintensity or isointensity (ie, portal vein hyperintensity sign, PVHS). Statistics encompassed linear regression, logistic regression, and survival analysis.

Results
There was an inverse correlation between HVPG and RLE (r
2 = 0.18, P < 0.0001). On univariate analysis, clinically significant PH (ie, HVPG ≥ 10 mm Hg, n = 109) and severe PH (ie, HVPG ≥ 12 mm Hg, n = 99) were associated with delayed biliary contrast excretion (n = 33) and the PVHS (n = 74) (P < 0.01 for all). Multivariate analysis demonstrated significant associations between the PVHS and severe PH (odds ratio [OR], 3.33; P = 0.008), independently of spleen size (OR, 1.26; P = 0.002), portosystemic collaterals (n = 81; OR, 5.46; P = 0.0001), and ascites (n = 88; OR, 3.24; P = 0.006). Lower RLE and the PVHS were associated with lower 3-year, transplantation-free survival (hazards ratios, 0.98 and 3.99, respectively, P = 0.002 for all), independently of the Child-Pugh and Model for End-Stage Liver Disease scores.

Conclusions
The presence of the PVHS on gadoxetic acid–enhanced MRI is an independent indicator of severe PH and may enable more accurate diagnosis. This feature and decreased hepatic contrast uptake may also comprise prognostic information.
ANIMAL-AIDED DESIGN – using a species’ life-cycle to improve open space planning and conservation in cities and elsewhere
Authors: Weisser Wolfgang W. , Hauck Thomas E. 
Published: June 2017

ABSTRACTBiodiversity underlies many of the ecosystem services demanded by humans. For cities, the design of ‘green infrastructures’ or ‘nature-based solutions’ has been proposed to maintain the provisioning of these services and the preservation of biodiversity. It is unclear, however, how such green infrastructure can be implemented, given existing planning practices that generally ignore biodiversity. Urban open spaces are normally designed by landscape architects with a primary focus on plants, aesthetic design and functionality for human users. As a consequence, conservation of species only plays a minor role, in fact, protected animals are often considered detrimental to the design, e.g. when the need to conserve a protected species demands modifications of a building project. Conversely, conservationists are often in favor of protected areas, also in cities, with little access for humans and no human design.We propose ‘Animal-Aided Design’ (AAD) as a methodology for the design of urban open spaces, to integrate conservation into open space planning. The basic idea of AAD is to include the presence of animals in the planning process, such that they are an integral part of the design. For AAD, the desired species are chosen at the beginning of a project. The requirements of the target species then not only set boundary conditions for the design, but also serve as an inspiration for the design itself. The aim of AAD is to establish a stable population at the project site, or contribute to population growth of species with larger habitats. AAD thus allows a combination of good urban design with species conservation. We illustrate our approach with designs for urban spaces in Munich.
Inducible, tunable and multiplex human gene regulation using CRISPR-Cpf1-based transcription factors
Authors: Tak Yu Gyoung , Kleinstiver Benjamin P. , Nuñez James K. , Hsu Jonathan Y. , Gong Jingyi , Weissman Jonathan S. , Keith Joung J. 
Published: June 2017

ABSTRACTTargeted and inducible regulation of mammalian gene expression is a broadly important research capability that may also enable development of novel therapeutics for treating human diseases. Here we demonstrate that a catalytically inactive RNA-guided CRISPR-Cpf1 nuclease fused to transcriptional activation domains can up-regulate endogenous human gene expression. We engineered drug-inducible Cpf1-based activators and show how this system can be used to tune the regulation of endogenous gene transcription in human cells. Leveraging the simpler multiplex capability of the Cpf1 platform, we show that we can induce both synergistic and combinatorial gene expression in human cells. Our work should enable the creation of other Cpf1-based gene regulatory fusion proteins and the development of multiplex gene perturbation library screens for understanding complex cellular phenotypes.
Histamine signalingviathe metabotropic receptorTrapped in endoderm 1regulates courtship initiation inDrosophila melanogaster
Authors: Zaki Sadaf A. , Sandhu Jaspal , French Rachael L. 
Published: June 2017

AbstractUnderstanding the role of genes in directing behavior is one of the primary goals of neuroscience. Mating behavior inDrosophilais controlled by male-specific splicing of the master regulatory genefruitless(fru), and the male-specific splice form,fruM, is both necessary and sufficient for all aspects of the courtship ritual. We have previously described the role ofTrapped in endoderm 1(Tre1) in courtship behavior.Tre1encodes an orphan G-protein-coupled receptor that is essential for normal courtship behavior in male flies. We previously found that feminizingTre1-expressing cells in males via expression of the female-specific splicing factor Transformer (TraF) resulted in rapid courtship initiation. Here we confirm that Tre1 is required in neurons for normal courtship behavior, and present genetic evidence that Tre1 acts through the downregulation of the E-cadherin Shotgun, and that the neurotransmitter histamine is the likely Tre1 ligand. Our findings are the first evidence for metabotropic histamine receptors inDrosophila, and the first to demonstrate a role for histamine in courtship.
Application of campus instructional support: two case studies
Authors: Clauss-Ehlers Caroline S. , Pasquerella Lynn 
Published: June 2017

Purpose
The purpose of this paper is to demonstrate how instructional support is a critical tool to promote the use of technology in research and teaching. A Campus-Wide Collaborative Model of Technological Instructional Support (CCMTIS) is presented that incorporates: integration of technology across campus; technical assistance; allocation of funding for technical assistance; support of faculty teaching style; and teaching that enhances learning through the use of technology.

Design/methodology/approach
The approach presents two case studies, one a large state research university, and the other a small liberal arts college.

Findings
Four overlapping themes emerge across the two case studies that demonstrate how: technology can connect classroom learning to career considerations and opportunities; develop writing and communication skills; promote career development through access to job search skills; and encourage professional development among faculty and staff.

Research limitations/implications
The limitations are that only two specific campus environments are examined. That these are differing environments, however, have implications for the model’s application to diverse campus settings.

Practical implications
A practical application is that the study demonstrates how the CCMTIS model can be applied to both classroom and campus. This has implications for other universities that may seek to replicate the model on their own campuses.

Social implications
The social implications indicate how learning occurs through an instructional support model that promotes collaboration. At the same time, ethical considerations related to instructional support are presented.

Originality/value
The manuscript reflects original work based on case studies that reflect the authors’ experiences.
Immunosuppressive efficacy of tetrandrine combined with methylprednisolone against mitogen‐activated peripheral blood mononuclear cells of haemodialysis patients
Authors: Xu Wencheng , Meng Kehan , Kusano Junichi , Matsuda Hiroto , Hara Yoshikazu , Fujii Yoshiaki , Suzuki Shinya , Ando Eiki , Wang Xiaoqin , Tu Yuanchao , Tanaka Sachiko , Sugiyama Kentaro , Yamada Haruki , Hirano Toshihiko 
Published: June 2017

AbstractImmunosuppressive therapy for prevention of acute rejection episode occasionally causes serious adverse effects, and thus it is important to develop new therapeutic approach for renal transplant recipients. This study evaluated the immunosuppressive pharmacodynamics of tetrandrine (TET) and/or methylprednisolone (MP) in haemodialysis patients in vitro by using the peripheral blood mononuclear cells (PBMCs) isolated from whole blood of haemodialysis patients. The median (range) of MP IC50 values against the proliferation of patients PBMCs was 7.04 (2.30‐500.00) ng/mL. In contrast, the median (range) of MP IC50 values against the proliferation of healthy PBMCs was 4.44 (3.19‐5.08) ng/mL. The median (range) of TET IC50 values against the proliferation of patients PBMCs was 1.61 (1.04‐4.79) μmol/L. Lower concentrations of TET (0.3‐300 nmol/L) were able to decrease the IC50 values of MP and thus potentiate the MP immunosuppressive effect on patient PBMCs. The median (range) of MP IC50 values in combination with 0.3, 3, 30, and 300 nmol/L TET were 0.92 (0.49‐8.39), 2.10 (0.45‐20.00), 0.35 (0.092‐1.05), and 0.14 (0.05‐6.78) ng/mL, respectively. TET potentiates the MP immunosuppressive pharmacodynamics and thus, it was possible to use the combination of MP and TET to attenuate MP side effects. There were significant correlations between the IC50 values of TET and stimulation indices (P=0.04, r=.58), the IC50 values of TET and the haemodialysis periods (P=0.04, r=.57), or the IC50 values of MP combined with 0.3 nmol/L TET and C‐reactive protein concentrations (P=0.04, r=.64), respectively.
Metacognition in speech and language therapy for children with social (pragmatic) communication disorders: implications for a theory of therapy
Authors: Gaile Jacqueline , Adams Catherine 
Published: June 2017

AbstractBackgroundMetacognition is a significant component of complex interventions for children who have developmental language disorders. Research into how metacognition operates in the content or process of developmental language therapy delivery is limited. Identification and description of proposed active therapy components, such as metacognition, may contribute to our understanding of how to deliver complex communication interventions in an optimal manner.AimsTo analyse aspects of metacognition during therapy derived from a manualized speech and language intervention (the Social Communication Intervention Programme—SCIP) as delivered to children who have social (pragmatic) communication disorder (SPCD) and to examine the dynamic process of delivering therapy.Methods & ProceduresA purposive sample of eight filmed therapy sessions was selected from the video data corpus of intervention‐arm participants within a randomized controlled trial. The child–therapist interactions during therapy sessions from five children (aged between 5;11 and 10;3) in the SCIP trial were transcribed. Filmed sessions represented a variety of communication profiles and SCIP therapy content. Starting from existing theory on metacognition, cycles of iterative analysis were performed using a mixed inductive‐deductive qualitative analysis. A preliminary list of metacognitive content embedded in the intervention was developed into a metacognitive coding framework (MCF). A thematic analysis of the identified metacognitive content of the intervention was then carried out across the whole sample.Outcomes & ResultsThematic analysis revealed the presence of metacognition in the content and delivery of SCIP intervention. Four main themes of metacognitive person, task and strategy knowledge, and monitoring/control were identified. Metacognition was a feature of how children's ability to monitor language, pragmatic and social interaction skills, in themselves and other people, was developed. Task design and delivery methods were found to play a particular role in adjusting the metacognitive content of the therapy activities.Conclusions & ImplicationsThis study makes explicit the metacognitive content and delivery within a complex developmental communication intervention. Discussion of the findings about metacognitive content provides an explanation of how the skilled speech and language therapist manipulates task demands, person knowledge and therapy methods towards the therapy goal. Clinical applications of the metacognitive framework are discussed. We suggest that the process of making the tacit knowledge of the therapist explicit can contribute to the implementation of complex evidence‐based interventions.
Moderate Alcoholic Beer Consumption: The Effects on the Lipid Profile and Insulin Sensitivity of Adult Men
Authors: Nogueira Luciana C. , do Rio Rafaela F. , Lollo Pablo C. B. , Ferreira Isabel M.P.L.V.O. 
Published: June 2017

AbstractBeer is the most consumed alcoholic beverage in the world. The purpose was to compare the effects of consuming alcoholic beer (AB) and nonalcoholic beer (NAB) on the biochemical blood parameters. Two beers were produced under known and controlled conditions from the same raw material, NAB (0.6%, v/v) and AB with the addition of 6% grain alcohol. Fifteen healthy adult men (aged 20 to 57 y) underwent 3 treatments (30 d per treatment). In Treatment 1 (Baseline), they followed their usual diet without drinking any alcoholic beverage; in Treatment 2, they added the daily consumption of 330 mL NAB; and in Treatment 3, they added the daily consumption of 330 mL AB. It was found that the use of AB for 30 d (16 g alcohol/d) reduced the blood insulin and fasting glucose, reducing insulin resistance. These data suggest that the daily intake of 330 mL AB could statistically change the lipid profile and insulin sensitivity of adult men. The volunteers were healthy before and remained so after the intervention, with no change in their clinical status.
Modeling Water Quantity and Sulfate Concentrations in the Devils Lake Watershed Using Coupled SWAT and CE‐QUAL‐W2
Authors: Shabani Afshin , Zhang Xiaodong , Ell Mike 
Published: June 2017

AbstractDevils Lake is an endorheic lake in the Red River of the North basin in northeastern North Dakota. During the last two decades, the lake water level has risen by nearly 10 m, causing floods that have cost more than 1 billion USD in mitigation measures. Another increase of approximately 1.5 m in the lake water level would cause spillage into the Sheyenne River. To alleviate this potentially catastrophic spillage, two artificial outlets were constructed. However, the artificial drainage of water into the Sheyenne River raises water quality concerns because the Devils Lake water contains significantly higher concentrations of dissolved solids, particularly sulfate. In this study, the Soil and Water Assessment Tool (SWAT) was coupled with the CE‐QUAL‐W2 model to simulate both water balance and sulfate concentrations in the lake. The SWAT model performed well in simulating daily flow in tributaries with ENS > 0.5 and |PBIAS| < 25%, and reproduced the lake water level with a root mean square error of 0.35 m for the study period from 1995 to 2014. The water temperature and sulfate concentrations simulated by CE‐QUAL‐W2 for the lake are in general agreement with the field observations. The model results show that the operation of the two outlets since August 2005 has lowered the lake level by 0.70 m. Furthermore, the models show pumping water from the two outlets raises sulfate concentrations in the Sheyenne River from ~100 to >500 mg/L. Editor's note: This paper is part of the featured series on SWAT Applications for Emerging Hydrologic and Water Quality Challenges. See the February 2017 issue for the introduction and background to the series.