bluuebunny/crossref_metadata_2025_split huggingface dataset:
Research Waste in ME/CFS
Authors: Lee Sonia 
Published: May 2017

AbstractObjectiveTo compare the prevalence of selective reporting in ME/CFS research areas: psychosocial versus cellular.MethodA bias appraisal was conducted on three trials (1x psychosocial and 2x cellular) to compare risk of bias in study design, selection and measurement. The primary outcome compared evidence and justifications in resolving biases by proportions (%) and ORs (Odds Ratio); the secondary outcome determined the proportion (in %) of ME/CFS grants at risk of bias.ResultsNS (cellular study) was twice as likely to present evidence in resolving biases over PACE (psychosocial trial) (OR = 2.16; 65.6% vs 46. 9%), but this difference was not significant (p= 0.13). However, NS was five times more likely to justify biases over PACE (OR = 4.76; 46.9% vs 15. 6%) and this difference was significant (p= 0.0095;p <0.05). PACE was weak in place (operational aspects 32%) and NS for data practices (37%). The proportion of grants were more biased in PACE (72%) than NS (28%) for evidence, and also more biased in PACE (86%) than NS (14%) for justifications.ConclusionPsychosocial trials on ME/CFS are more likely to engage in selective reporting indicative of research waste than cellular trials. Improvements to place may help reduce these biases, whereas cellular trials may benefit from adopting more translatable data methods. However, these findings are based on two trials. Further risk of bias appraisals are needed to determine the number of trials required to make robust these findings.
Microbial metagenome of urinary tract infection
Authors: Moustafa Ahmed , Singh Harinder , Li Weizhong , Moncera Kelvin J. , Torralba Manolito G. , Yu Yanbao , Manuel Oriol , Biggs William , Craig Venter J. , Nelson Karen E. , Pieper Rembert , Telenti Amalio 
Published: May 2017

AbstractUrine culture and microscopy techniques are used to profile the bacterial species present in urinary tract infections. To gain insight into the urinary flora in infection and health, we analyzed clinical laboratory features and the microbial metagenome of 121 clean-catch urine samples. 16S rDNA gene signatures were successfully obtained for 116 participants, while whole genome shotgun sequencing data was successfully generated for samples from 49 participants. Analysis of these datasets supports the definition of the patterns of infection and colonization/contamination. Although 16S rDNA sequencing was more sensitive, whole genome shotgun sequencing allowed for a more comprehensive and unbiased representation of the microbial flora, including eukarya and viral pathogens, and of bacterial virulence factors. Urine samples positive by whole genome shotgun sequencing contained a plethora of bacterial (median 41 genera/sample), eukarya (median 2 species/sample) and viral sequences (median 3 viruses/sample). Genomic analyses revealed cases of infection with potential pathogens (e.g.,Alloscardovia sp, Actinotignum sp,Ureaplasma sp) that are often missed during routine urine culture due to species specific growth requirements. We also observed gender differences in the microbial metagenome. While conventional microbiological methods are inadequate to identify a large diversity of microbial species that are present in urine, genomic approaches appear to comprehensively and quantitatively describe the urinary microbiome.
A specific non-bisphosphonate inhibitor of the bifunctional farnesyl/geranylgeranyl diphosphate synthase in malaria parasites
Authors: Gisselberg Jolyn E. , Herrera Zachary , Orchard Lindsey , Llinás Manuel , Yeh Ellen 
Published: May 2017

SummaryIsoprenoid biosynthesis is essential forPlasmodium falciparum(malaria) parasites and contains multiple validated antimalarial drug targets, including a bifunctional farnesyl and geranylgeranyl diphosphate synthase (FPPS/GGPPS). We identified MMV019313 as an inhibitor ofPfFPPS/GGPPS. ThoughPfFPPS/GGPPS is also inhibited by a class of bisphosphonate drugs, MMV019313 has significant advantages for antimalarial drug development. MMV019313 has superior physicochemical properties compared to charged bisphosphonates that have poor bioavailability and strong bone affinity. We also show that it is highly selective forPfFPPS/GGPPS and showed no activity against human FPPS or GGPPS. Inhibition ofPfFPPS/GGPPS by MMV019313, but not bisphosphonates, was disrupted in an S228T variant, demonstrating that MMV019313 and bisphosphonates have distinct modes-of-inhibition againstPfFPPS/GGPPS. Altogether MMV019313 is the first specific, non-bisphosphonate inhibitor ofPfFPPS/GGPPS. Our findings uncover a new small molecule binding site in this important antimalarial drug target and provide a promising starting point for development ofPlasmodium-specific FPPS/GGPPS inhibitors.
Accounting for madness: the “Real Casa dei Matti” of Palermo 1824-1860
Authors: Funnell Warwick , Antonelli Valerio , D’Alessio Raffaele , Rossi Roberto 
Published: May 2017

Purpose
The purpose of this paper is to understand the role played by accounting in managing an early nineteenth century lunatic asylum in Palermo, Italy.

Design/methodology/approach
The paper is informed by Foucault’s studies of lunatic asylums and his work on governmentality which gave prominence to the role of statistics, the “science of the State”.

Findings
This paper identifies a number of roles played by accounting in the management of the lunatic asylum studied. Most importantly, information which formed the basis of accounting reports was used to describe, classify and give visibility and measurability to the “deviance” of the insane. It also legitimated the role played by lunatic asylums, as entrusted to them in post-Napoleonic early nineteenth century society, and was a tool to mediate with the public authorities to provide adequate resources for the institution to operate.

Research limitations/implications
This paper encourages accounting scholars to engage more widely with socio-historical research that will encompass organisations such as lunatic asylums.

Originality/value
This paper provides, for the first time, a case of accounting applied to a lunatic asylum from a socio-historical perspective.
Hybrid accounts: Shell’s letter to Mr and Mrs shareholder
Authors: Pupovac Sanja , Moerman Lee 
Published: May 2017

Purpose
The purpose of this paper is to use a hybrid account of oil spills in Nigeria to explore the recursive relationship between a multinational company, specific shareholders and the public. A response to Mr and Mrs Shareholders’ concerns is considered an exercise in corporate discursive hegemony and enacts rhetorical accountability.

Design/methodology/approach
The authors adopt Debord’s (1967, 1988) concept of the spectacle with Boje’s (2001) antenarrative approach as a critical postmodern framing of Shell’s narrative of oil spills in both local and global contexts. An antenarrative approach considers how stories are woven to produce a unified and omnipotent narrative or image.

Findings
MNCs face considerable uncertainties arising from the operational conditions in developing countries and produce a range of accounts for spectators. As theatrical events, they contribute to the spectacle of power that rationalises controversy and suppresses resistance.

Research limitations/implications
To overcome the limitations of using a single document as empirical material the authors consider the response letter as an example of an institutional framing of oil spill phenomena in general.

Social implications
By understanding the construction of the spectacle the authors open avenues for resistance to corporate discursive hegemony in the form of carnivalesque.

Originality/value
The paper adds to the understanding of hybrid forms of resistance in an era of increasing MNC power and reach. It demonstrates how the actual production and distribution has persuasive power as a form of rhetorical accountability.
The relationship between transformational client leadership and auditor objectivity
Authors: Svanberg Jan , Öhman Peter , Neidermeyer Presha E. 
Published: May 2017

PurposeThe purpose of this paper is to investigate whether transformational leadership affects auditor objectivity.Design/methodology/approachThe investigation is based on a field survey of 198 practicing auditors employed by audit firms operating in Sweden.FindingsThis study finds that transformational client leadership negatively affects auditor objectivity and that the effect is only partially mediated by client identification. Given these results, suggesting that auditors are susceptible to influence by their clients’ perceived exercise of transformational leadership, leadership theory appears relevant to the discussion of auditor objectivity in the accounting literature.Originality/valuePrevious accounting research has applied the social identity theory framework and found that client identification impairs auditor objectivity. However, the effect of transformational client leadership on auditor objectivity, which reflects an intense auditor-client relationship, has been neglected before this study.
Is mental capacity in the eye of the beholder?
Authors: Ruck Keene Alex 
Published: May 2017

Purpose
The purpose of this paper – written by a practising barrister specialising in the Mental Capacity Act 2005 – is to survey law and practice in England and Wales with a view to sketch out a preliminary answer as to whether it can be said there is, in fact, any legally defensible concept of mental capacity.

Design/methodology/approach
Review of case-law in England and Wales and relevant domestic and international law, in particular the Mental Capacity Act 2005 and the Convention on the Rights of Persons with Disabilities (“CRPD”).

Findings
It is right, and inescapable, to say that mental capacity is in the eye of the beholder, and will remain so even if we seek to recast our legislative provisions. Rather – and perhaps ironically – the conclusion set out above means that we need to look less at the person being assessed, and more at the person doing the assessing. We also need to further look at the process of assessment so as to ensure that those who are required to carry it out are self-aware and acutely alive to the values and pre-conceptions that they may be bringing to the situation.

Research limitations/implications
It seems to me that it is right, and inescapable, to say that mental capacity is in the eye of the beholder, and will remain so even if we seek to recast our legislative provisions. Absent major developments in neuroscience, it will inescapably remain a concept which requires judgments based on interactions between the assessor and the assessed. But that is not thereby to say that it is an irremediably relative and flawed concept upon which we cannot place any weight. Rather the conclusion set out above means that we need to look less at the person being assessed, and more at the person doing the assessing. We also need further to look at the process of assessment so as to ensure that those who are required to carry it out are self-aware and acutely alive to the values and pre-conceptions that they may be bringing to the situation.

Originality/value
This paper serves as a reflection on the best part of a decade spent grappling with the MCA 2005 in and out of the court room, a decade increasingly informed by and challenged by the requirements of the CRPD.
Information behaviour and decision-making in patients during their cancer journey
Authors: Chen Shih-Chuan 
Published: May 2017

PurposeThis paper aims to investigate the effect of cancer patients’ information behaviour on their decision-making at the diagnosis and treatment stages of their cancer journey. Patients’ information sources and their decision-making approaches were analyzed.Design/methodology/approachSemi-structured interviews were conducted with 15 participants.FindingsThe cancer patients sought information from various sources in choosing a hospital, physician, treatment method, diet and alternative therapy. Physicians were the primary information source. The patients’ approaches to treatment decision-making were diverse. An informed approach was adopted by nine patients, a paternalistic approach by four and a shared decision-making approach by only two.Practical implicationsIn practice, the findings may assist hospitals and medical professionals in fostering pertinent interactions with patients.Originality/valueThe findings can enhance researcher understanding regarding the effect of cancer patients’ information behaviour on their decision-making.
Modelling web-based library service quality and user loyalty in the context of a developing country
Authors: Haruna Bala , Kiran K. , Tahira Muzammil 
Published: May 2017

PurposeThis study aims to empirically validate the LibWebSQ measurement scale. In addition, it investigates the relationship between perceived web-based service quality and three other latent constructs, namely, user satisfaction, service value and user loyalty.Design/methodology/approachA quantitative survey design was used to collect the data. Structural equation modeling was used to determine the influence of web-based service quality on the three latent constructs. The respondents were students, academic staff and non-academic staff from two federal universities in the North-western zone of Nigeria.FindingsThe findings of the path analysis indicate that perceived web-based service quality and service value exhibit no statistically significant direct influence on user loyalty. However, user satisfaction has a direct positive influence on user loyalty, and it also mediates the relationship between web-based service quality and user loyalty to the library.Research limitations/implicationsThe LibWebSQ is a reliable and valid scale to be used in Nigerian university libraries for web-based service quality measurement. User loyalty in academic libraries can be modelled as a result of service quality and user satisfactionPractical implicationsThis study provides a means of assessing web-based library service quality and further improving the policy and practice in university libraries.Originality valueThis is the first attempt to assess web-based library service quality using the LibWebSQ measurement scale. A satisfactory model fit is obtained, which allows the measurement model to be integrated with service value, user satisfaction and user loyalty. The study contributes to the conceptualization of web-based library service quality.
MHD-mixed convection flow in a lid-driven trapezoidal cavity under uniformly/non-uniformly heated bottom wall
Authors: Javed T. , Mehmood Z. , Pop Ioan 
Published: May 2017

PurposeThe purpose of this paper is to analyze numerical results for heat transfer through mixed convection in an incompressible steady lid-driven fluid flow inside a trapezoidal cavity in the presence of a uniform magnetic field.Design/methodology/approachIn this study, the authors have considered three different cases, in which left and right walls of the cavity are tilted at different angles of 0, 30 and 45 degrees, respectively. Both left and right side walls of the cavity are taken cold and the upper wall is insulated and assumed moving with constant speed, whereas the bottom wall is considered to be heated uniformly/non-uniformly. To eliminate pressure term, penalty method is applied to governing Navier–Stokes’ equations. The reduced equations are solved by Galerkin weighted residual technique of finite element method. Grid-independent results are obtained and shown in terms of plots for streamlines, isotherms, Nusselt number and average Nusselt number for a wide range of flow parameters, including Rayleigh numbers Ra, Prandtl number Pr and Hartman number Ha.FindingsIt has been observed that the effects of moving lid become negligible for Ra = 100,000, whereas increasing Rayleigh number results in stronger streamline circulation and convection dominant effects inside the enclosure. Local Nusselt number Nu along the bottom wall is observed to be maximum at edges and it reduces while moving toward the center from edges, and attains minimum value at the center of the bottom wall.Research limitations/implicationsThe problem is modeled for laminar and incompressible flow, induced magnetic field has been considered negligibly small and local thermal equilibrium has been assumed.Originality/valueIn this investigation, the authors have presented new and original results for mixed convection flow inside a lid-driven trapezoidal cavity under the influence of a magnetic field. Hence, this study would be important for the researchers working in the area of heat transfer in cavity flows involving magnetic effects to become familiar with the flow behavior and properties.
Unsteady general solution for MHD natural convection flow with radiative effects, heat source and shear stress on the boundary
Authors: Fetecau Constantin , Akhtar Shahraz , Pop Ioan , Fetecau Corina 
Published: May 2017

Purpose
The purpose of this note is to provide general solutions for radiative magnetohydrodynamic natural convection flow.

Design/methodology/approach
To obtain exact solutions for such motions of Newtonian fluids, as seen in the existing literature, the Laplace transform technique is used.

Findings
General solutions are obtained for temperature, velocity and Nusselt number in the presence of heat source and shear stress on the boundary. They can generate exact solutions for any motion with technical relevance of this type. Fluid velocity is presented as the sum of mechanical and thermal components. Influence of physical parameters on temperature and velocity is graphically underlined for ramp-type heating plate that applies a constantly accelerating shear stress to the fluid. Thermal and mechanical effects are significant and must be taken into consideration.

Practical implications
For illustration, as well as for a check of results, three special cases with applications in engineering are considered and some known results are recovered.

Originality/value
Obtained solutions are presented in the simplest forms. In addition, the solutions corresponding to cosine oscillatory heating and oscillating shear are presented so that they can be immediately reduced to those corresponding to constant heating and uniform shear if the oscillations’ frequency becomes zero. Heat transfer characteristics with thermal radiation are graphically illustrated using one parameter only for such motions.
Numerical simulation of a hypersonic flow past a blunt body
Authors: Hu Yumeng , Huang Haiming , Zhang Zimao 
Published: May 2017

Purpose
The purpose of this paper is to explore the characteristics of hypersonic flow past a blunt body.

Design/methodology/approach
The implicit finite volume schemes are derived from axisymmetric Navier–Stokes equations by means of AUSM+ and LU-SGS methods, and programmed in FORTRAN. Based on the verified result that a 2D axisymmetric chemical equilibrium flow has a good agreement with the literature, the characteristics of hypersonic flow past a sphere are simulated by using four different models which involve four factors, namely, viscous, inviscid, equilibrium and calorically perfect gas.

Findings
Compared with the calorically perfect gas under hypervelocity condition, the shock wave of the equilibrium gas is more close to the blunt body, gas density and pressure become bigger, but gas temperature is lower due to the effect of real gas. Viscous effects are not obvious in the calculations of the equilibrium gas or the calorically perfect gas. In a word, the model of equilibrium gas is more suitable for hypersonic flow and the calculation of viscous flow has a smaller error.

Originality/value
The computer codes are developed to simulate the characteristics of hypersonic flows, and this study will be helpful for the design of the thermal protection system in hypersonic vehicles.
Employees’ justice perceptions as a factor influencing successful outsourcing in the hospitality industry
Authors: Zoghbi-Manrique-de-Lara Pablo , Ting-Ding Jyh-Ming 
Published: May 2017

PurposeThis study aims to hypothesize that the more in-house staff perceive themselves as beneficiaries of the procedural justice (PJ) followed in the outsourcing, or perceive their outsourced peers as recipients of distributive (DJ) and interactional justice (IJ), the more they will show acceptance and positive evaluations of the outsourcing initiatives. Although prior research in the hospitality industry has extensively studied individual-level reactions to organizational justice, no study has been undertaken to examine how hotel staff support and value outsourcing initiatives based on the way they perceive management’s treatment of them and their peers.Design/methodology/approachQuestionnaire data from 215 in-house employees working side-by-side with outsourced employees at 14 hotels in Gran Canaria (Spain) were analyzed by using structural equation modeling.FindingsThe results found that in-house employees who perceived themselves or their outsourced peers as recipients of organizational justice to a greater extent reported greater support for outsourcing by expressing higher levels of acceptance and better evaluations. The results also supported procedural justice (PJ) as playing a dominant role over distributive (DJ) and interactional justice (IJ).Research limitations/implicationsThe findings suggest that by encouraging justice perceptions among in-house employees, mainly those related to properly discussing the outsourcing procedures with affected employees, hotel managers can promote successful outsourcing. Given that in-house employees reacted not only to the way they were treated by hotel management but also to the way their outsourced peers were treated, the findings also indicate that all (un)fair treatment in outsourcing, regardless of the recipient, should receive explicit attention by hotel managers.Originality/valueThis paper is one of the first to primarily focus on the individual level of analysis in examining and supporting organizational justice in hotel firms as a factor influencing outsourcing success.
Moving beyond the Western versus Asian culture distinction
Authors: Weber Karin , Sparks Beverley , Hsu Cathy H.C. 
Published: May 2017

PurposeThis study aims to analyze the joint effects of where a service failure occurs and who witnesses it, with a specific focus on Chinese consumers who have varying levels of acculturation.Design/methodology/approachA 4 × 2 × 2 between-subject factorial design was used, where social presence and the location of the service failure were manipulated and acculturation was measured. Data were collected in Australia and China to contrast perceptions and behavioral responses of Chinese – Australians and Mainland Chinese by drawing on samples of 224 and 264 respondents, respectively.FindingsResults showed significant differences in face, satisfaction and repeat purchase intention ratings following a service failure between Chinese – Australians and Mainland Chinese, as well as among Chinese – Australians with different acculturation strategies. Contrary to expectations, results established that where and with whom a service failure is experienced prominently affect consumer behavior regardless of the acculturation level.Practical implicationsAn understanding of the effect of acculturation on a service failure situation is crucial for businesses to successfully compete in a continuously globalized world where migration produces multicultural societies and short-term travel tends to significantly change demands on service provision.Originality/valueThis research presents one of the first studies that go beyond the traditional East/West consumer distinction in studying service failure. This study analyzes the effect of acculturation by itself and together with other variables of interest.