bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential sampling plans and economic injury levels for Empoasca kraemeri on common bean crops at different technological levels
Authors: de Moura Marcelo Fialho , Lopes Mayara Cristina , Pereira Renata Ramos , Parish Jorgiane Benevenute , Chediak Mateus , de Paulo Arcanjo Lucas , das Graças do Carmo Daiane , Picanço Marcelo Coutinho 
Published: September 2017

AbstractBACKGROUNDEmpoasca kraemeri is an important pest on common bean crops at different technological levels. However, for this pest on this crop, economic injury levels have not yet been determined and plan for sequential sampling plans has not yet been developed. Thus, the objectives of this research were to develop E. kraemeri sequential sampling plans and to determine economic injury levels in the common bean at different crop technological levels.RESULTSCommon bean plants tolerate low attack intensities of this pest (up to 1 adult plant‐1). However, with an increase in attacks, there is a reduction in grain production by the plants. The economic injury levels were 0.48, 0.39 and 0.35 adults sample‐1 (leaf beating on a tray) for crops with low (1200 kg ha‐1), medium (1800 kg ha‐1) and high (2400 kg ha‐1) technological levels, respectively. Sequential sampling plans and the standardized plan produced similar decisions. However, in these decisions there was a time saving of more than 60% compared with the standardized plan.CONCLUSIONAll three economic injury levels determined and the sequential sampling plans developed in this study are suitable for incorporation into integrated management programs for common bean pests because they can be used by farmers operating at various technological levels to make adequate and rapid decisions. © 2017 Society of Chemical Industry
Identification and characterization of vilazodone metabolites in rats and microsomes by ultrahigh‐performance liquid chromatography/quadrupole time‐of‐flight tandem mass spectrometry
Authors: Chavan Balasaheb B. , Kalariya Pradipbhai D. , Tiwari Shristy , Nimbalkar Rakesh D. , Garg Prabha , Srinivas R. , Talluri M.V.N. Kumar 
Published: September 2017

RationaleVilazodone is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of major depressive disorder (MDD). An extensive literature search found few reports on the in vivo and in vitro metabolism of vilazodone. Therefore, we report a comprehensive in vivo and in vitro metabolic identification and structural characterization of vilazodone using ultrahigh‐performance liquid chromatography/quadrupole time‐of‐flight tandem mass spectrometry (UPLC/Q‐TOF/MS/MS) and in silico toxicity study of the metabolites.MethodsTo identify in vivo metabolites of vilazodone, blood, urine and faeces samples were collected at different time intervals starting from 0 h to 48 h after oral administration of vilazodone to Sprague‐Dawley rats. The in vitro metabolism study was conducted with human liver microsomes (HLM) and rat liver microsomes (RLM). The samples were prepared using an optimized sample preparation approach involving protein precipitation followed by solid‐phase extraction. The metabolites have been identified and characterized by using LC/ESI‐MS/MS.ResultsA total of 12 metabolites (M1–M12) were identified in in vivo and in vitro matrices and characterized by LC/ESI‐MS/MS. The majority of the metabolites were observed in urine, while a few metabolites were present in faeces and plasma. Two metabolites were observed in the in vitro study. A semi‐quantitative study based on percentage counts shows that metabolites M11, M6 and M8 were observed in higher amounts in urine, faeces and plasma, respectively.ConclusionsThe structures of all the 12 metabolites were elucidated by using LC/ESI‐MS/MS. The study suggests that vilazodone was metabolized via hydroxylation, dihydroxylation, glucuronidation, oxidative deamination, dealkylation, dehydrogenation and dioxidation. All the metabolites were screened for toxicity using an in silico tool.
Consequences of different cutting regimes on regrowth and nutrient stoichiometry of Sparganium erectum L. and Potamogeton natans L.
Authors: Bal K.D. , Verschoren V. , Sara J.R. , Meire P. , Schoelynck J. 
Published: September 2017

AbstractAquatic vegetation forms an essential component in freshwater ecosystems but due to changed environmental and anthropogenic conditions often needs management to reduce nuisance for human land‐use. In this paper, the authors looked at the regrowth of two macrophyte species (Potamogeton natans and Sparganium erectum) in two lowland rivers under different cutting treatments. After an initial cross‐sectional transect was manually removed from bank to bank at the beginning of the growth season, a monthly repetitive removal of biomass in plots on that transect was done during the rest of the growth season (testing frequency of mowing). Additional new transects were also cut in subsequent months (testing timing of mowing). Finally, biomass was repetitively removed in plots in those additional transects too (testing frequency of mowing × timing of mowing). The biomass at the end of the growth season was analysed for C, N, P, and Si. It was demonstrated that timing and frequency of vegetation cutting has an important effect on the capacity and rate of species' recovery and therefore on the efficiency of the applied management. Nutrient stoichiometry of the regrown biomass was directly affected by cutting. Caused by differences in the applied timing and frequency of the cutting, C/N and N/P ratios and BSi concentrations were highly variable. Yet, overall, there was a clear tendency towards a higher C/N ratio and BSi concentration and lower N/P ratio in biomass that recovered after cutting. This human impact on the quantity and quality of autochthonous organic matter may have knock‐on effects on the decomposers food web and mineralization process.
Feasibility of Coping Effectiveness Training for Caregivers of Children with Autism Spectrum Disorder: a Genetic Counseling Intervention
Authors: Haakonsen Smith Christy , Turbitt Erin , Muschelli John , Leonard Lori , Lewis Katie L. , Freedman Brian , Muratori Michelle , Biesecker Barbara B. 
Published: September 2017

AbstractCaregivers of children with autism spectrum disorder (ASD) may find it difficult to feel a sense of control and to cope with the overall physical and emotional demands of caring for their child. While caregivers are able to successfully cope with a high level of stress, there are limits to their resources and abilities to cope over time. Genetic counselors working with affected families may be able to help parents more effectively manage stress related to the disorder. Few short‐term interventions have been reported in genetic counseling yet implementation of evidence‐based examples may be achievable. This study aimed to assess the feasibility of a coping effectiveness training (CET) intervention designed to enhance coping self‐efficacy (CSE) among caregivers of children with ASD, with the eventual goal of translating this intervention into genetic counseling practice. A randomized treatment‐control design was used to investigate the feasibility of an intervention using CET among caregivers of children with ASD. The primary outcome was the feasibility of the intervention; the secondary outcome was improvements in CSE in the intervention group as compared to the control group. Caregivers were recruited and randomized into the treatment (n=15) or control (n=13) groups. Of these, 22 completed the study (retention: 78.6%). The intervention was highly feasible; most caregivers found the CET helpful, practical, useful, and relatively easy to attend. The treatment group demonstrated significantly increased CSE from pre‐intervention to post‐intervention (p=0.02). Between group differences were not significant when comparing the pre‐post changes. We provide preliminary evidence that CET may be beneficial to caregivers of children with ASD. The results of this feasibility study support development of a phase II study of this intervention in a larger cohort, aimed to be implemented into a genetic counseling setting.
Magnetic Resonance Signal Abnormalities within the Pericruciate Fat Pad: A Possible Secondary Sign for Acute Anterior Cruciate Ligament Tears
Authors: Draghi Ferdinando , Torresi Mario , Urciuoli Luigi , Gitto Salvatore 
Published: September 2017

Purpose The study sought to investigate the presence of magnetic resonance (MR) signal alterations within the pericruciate fat pad in patients with an acute anterior cruciate ligament (ACL) tear as well as evaluate its diagnostic value in comparison with the main secondary signs of ACL tears. Methods Two musculoskeletal radiologists retrospectively reviewed knee MR examinations performed from May to October 2015. The ACL was considered as torn or intact based on either previous arthroscopic findings or unequivocal MR imaging interpretation if arthroscopic correlation was unavailable. Abnormalities of the pericruciate fat pad were evaluated as increased signal on the fluid-sensitive sequences; the main secondary signs of ACL tears were identified. Sensitivity and specificity were calculated for each sign. Results A total of 182 patients entered this study: 22 with an acute ACL tear, 160 with intact ACL. Signal hyperintensity of the pericruciate fat pad was demonstrated in all patients with an acutely torn ACL, resulting significantly different between individuals with intact ACL and those with ligament tear ( P < .0001). This sign was much more sensitive (100%) but less specific (72.5%-75%) than other secondary signs. Conclusions Signal hyperintensity of the pericruciate fat pad on the fluid-sensitive sequences is associated with acute ACL tears and could be considered as a possible indicator of these injuries.
Consequences of perinatal hypoxia in developing brain: Changes in GABA transporter functioning in cortical, hippocampal and thalamic rat nerve terminals
Authors: Pozdnyakova Natalia 
Published: September 2017

AbstractPerinatal hypoxia leads to behavioral abnormalities, cognitive disabilities, and epilepsy resulting from alterations in neurodevelopment, maturation and construction of the network. Considering a particular role of γ‐aminobutyric acid (GABA) for an immature brain, we analysed transporter‐mediated [3H]GABA uptake in the cortical, hippocampal and thalamic nerve terminals isolated from rats of different age in the control and after perinatal hypoxia. The state of hypoxia was induced by exposure of rats at the age of 10 postnatal days (pd) (that corresponds approximately to the time of birth in humans) to a respiratory medium with low O2 content (4% O2 and 96%N2) for 12 min (up to the initiation of clonico‐tonic seizures). Here, we found that the initial rate of [3Н]GABA uptake was higher in the young rats (pd 17–19) as compared to the older ones (pd 24–26, 38–40 and 66–73) in both control and hypoxia groups. It decreased abruptly by 50% in the thalamus and by 25% in the cortex for the period from pd 17–19 to pd 66–73. In the hippocampus, a decrease in the rate during the same time interval was 25%. Exposure to hypoxia had no effect on the intensity of [3Н]GABA uptake by the cortical and thalamic nerve terminals, but caused a significant age‐dependent attenuation (by 35%) of the uptake intensity in the hippocampal ones. Significant age‐dependent hypoxia‐independent decrease in [3Н]GABA uptake with step‐like dynamics of changes was shown in the thalamus and cortex. Gradual age‐dependent hypoxia‐dependent decrease in [3Н]GABA uptake was revealed in the hippocampus, and so a particular vulnerability of the latest structure to hypoxia as compared to the cortex and thalamus was revealed.
Impact of pre-operative serum 25-hydroxyvitamin D on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre: retrospective study of 246 patients
Authors: Erlem M , Klopp-Dutote N , Biet-Hornstein A , Strunski V , Page C 
Published: September 2017

AbstractObjective:To determine whether pre-operative serum 25-hydroxyvitamin D has an impact on post-operative parathyroid hormone and serum calcium levels in patients undergoing total thyroidectomy for benign goitre.Methods:This single-centre, retrospective study comprised 246 unselected surgical patients who had undergone total thyroidectomy for bilateral, benign, multinodular goitre. The correlation between pre-operative serum 25-hydroxyvitamin D and post-operative serum parathyroid hormone and serum calcium was studied to determine whether low pre-operative serum 25-hydroxyvitamin D was predictive of post-operative hypocalcaemia.Results:Seventy-nine patients (32 per cent) had post-operative hypocalcaemia. Eighteen patients (7.32 per cent) experienced unintentional parathyroidectomy (1 parathyroid gland in 15 patients, 2 parathyroid glands in 3 patients). In univariate analysis, pre-operative serum 25-hydroxyvitamin D was not correlated with post-operative serum calcium (p = 0.69) or post-operative serum parathyroid hormone (p = 0.5804). Furthermore, in multivariate analysis, which took into account unintentional parathyroidectomy, no correlation was found (p = 0.33). Bilateral unintentional parathyroidectomy was statistically associated with post-operative hypocalcaemia (p = 0.032).Conclusion:Pre-operative serum 25-hydroxyvitamin D did not appear to have any impact on post-operative serum calcium in patients undergoing total thyroidectomy for benign goitre.
Audiological outcome of stapes surgery for far advanced cochlear otosclerosis
Authors: Heining C , Banga R , Irving R , Coulson C , Monksfield P 
Published: September 2017

AbstractBackground:Patients with advanced otosclerosis can present with hearing thresholds eligible for cochlear implantation. This study sought to address whether stapes surgery in this patient group provides a clinically significant audiological benefit.Objectives:To assess pre- and post-operative hearing outcomes of patients with advanced otosclerosis, and to determine what proportion of these patients required further surgery including cochlear implantation.Methods:Between 2002 and 2015, 252 patients underwent primary stapes surgery at our institution. Twenty-eight ears in 25 patients were deemed to have advanced otosclerosis, as defined by pure audiometry thresholds over 80 dB. The patients’ records were analysed to determine audiological improvement following stapes surgery, and assess whether any further surgery was required.Results:The audiological outcome for most patients who underwent primary stapes surgery was good. A minority of patients (7 per cent) required revision surgery. Patients who underwent cochlear implantation after stapes surgery (10 per cent) also demonstrated a good audiological outcome.Conclusion:Stapes surgery is a suitable treatment option for patients with advanced otosclerosis, and should be considered mandatory, before offering cochlear implantation, for those with a demonstrable conductive component to their hearing loss. A small group of patients get little benefit from surgery and subsequently a cochlear implant should be considered.
The Date of the Bucolic Poet Martius Valerius
Authors: Stover Justin A. 
Published: September 2017

ABSTRACTThe collection of four Latin bucolics ascribed to one Martius Valerius was only published in the twentieth century; they have been widely considered as twelfth-century compositions. Picking up on suggestions proposed by François Dolbeau, this study presents evidence that Martius drew directly on the bucolics of Theocritus, and that his poems are late antique, not medieval, literary productions, probably written in the sixth century. Such a conclusion will require a revision of the history of post-Virgilian Latin bucolic poetry.
Differences in Neurocognitive Impairment Among HIV-Infected Latinos in the United States
Authors: Marquine María J. , Heaton Anne , Johnson Neco , Rivera-Mindt Monica , Cherner Mariana , Bloss Cinnamon , Hulgan Todd , Umlauf Anya , Moore David J. , Fazeli Pariya , Morgello Susan , Franklin Donald , Letendre Scott , Ellis Ron , Collier Ann C. , Marra Christina M. , Clifford David. B. , Gelman Benjamin B. , Sacktor Ned , Simpson David , McCutchan J. Allen , Grant Igor , Heaton Robert K. 
Published: September 2017

AbstractObjectives: Human immunodeficiency virus (HIV) disproportionately affects Hispanics/Latinos in the United States, yet little is known about neurocognitive impairment (NCI) in this group. We compared the rates of NCI in large well-characterized samples of HIV-infected (HIV+) Latinos and (non-Latino) Whites, and examined HIV-associated NCI among subgroups of Latinos. Methods: Participants included English-speaking HIV+ adults assessed at six U.S. medical centers (194 Latinos, 600 Whites). For overall group, age: M=42.65 years, SD=8.93; 86% male; education: M=13.17, SD=2.73; 54% had acquired immunodeficiency syndrome. NCI was assessed with a comprehensive test battery with normative corrections for age, education and gender. Covariates examined included HIV-disease characteristics, comorbidities, and genetic ancestry. Results: Compared with Whites, Latinos had higher rates of global NCI (42% vs. 54%), and domain NCI in executive function, learning, recall, working memory, and processing speed. Latinos also fared worse than Whites on current and historical HIV-disease characteristics, and nadir CD4 partially mediated ethnic differences in NCI. Yet, Latinos continued to have more global NCI [odds ratio (OR)=1.59; 95% confidence interval (CI)=1.13–2.23; p<.01] after adjusting for significant covariates. Higher rates of global NCI were observed with Puerto Rican (n=60; 71%) versus Mexican (n=79, 44%) origin/descent; this disparity persisted in models adjusting for significant covariates (OR=2.40; CI=1.11–5.29; p=.03). Conclusions: HIV+ Latinos, especially of Puerto Rican (vs. Mexican) origin/descent had increased rates of NCI compared with Whites. Differences in rates of NCI were not completely explained by worse HIV-disease characteristics, neurocognitive comorbidities, or genetic ancestry. Future studies should explore culturally relevant psychosocial, biomedical, and genetic factors that might explain these disparities and inform the development of targeted interventions. (JINS, 2018, 24, 163–175)
Curbing food waste: A review of recent policy and action in the USA
Authors: Walia Bhavneet , Sanders Shane 
Published: September 2017

AbstractThe present study reviews previous published estimates as to the scale of food waste in the USA and its ecological toll (e.g., in terms of methane emissions and water usage to support the production of wasted food). The review further discusses recent public policy and private action designed to curb food waste or to apply wasted food toward hunger alleviation, biofuel production and soil nourishment. We further consider and expand upon previous estimates comparing the scale of food waste to the present scale of the US hunger problem. These estimates suggest that the recovery and redirection of an additional 15% of the present stock ofediblefood waste would meet 35% of the caloric needs of all Americans living in a food insecure household or very low food security household. Then, a modest to moderate proportional increase in edible food waste recovery could greatly reduce the US hunger problem in its present state. We estimate that the successful redirection of 15% of presently-wasted (edible) food in the USA would be sufficient to fully sustain 18.45 million individuals. Given available data, we cannot precisely assess the nutritional characteristics of this potential stock of food. The present study emphasizes the traditional and future importance of integrated public policy and private action at the municipal level, as food waste is typically disposed of or recovered at this level.
A genome-wide association study identifies a novel susceptibility locus for the immunogenicity of polyethylene glycol
Authors: Chang Chia-Jung , Chen Chien-Hsiun , Chen Bing-Mae , Su Yu-Cheng , Chen Ying-Ting , Hershfield Michael S. , Lee Ming-Ta Michael , Cheng Tian-Lu , Chen Yuan-Tsong , Roffler Steve R. , Wu Jer-Yuarn 
Published: September 2017

AbstractConjugation of polyethylene glycol (PEG) to therapeutic molecules can improve bioavailability and therapeutic efficacy. However, some healthy individuals have pre-existing anti-PEG antibodies and certain patients develop anti-PEG antibody during treatment with PEGylated medicines, suggesting that genetics might play a role in PEG immunogenicity. Here we perform genome-wide association studies for anti-PEG IgM and IgG responses in Han Chinese with 177 and 140 individuals, defined as positive for anti-PEG IgM and IgG responses, respectively, and with 492 subjects without either anti-PEG IgM or IgG as controls. We validate the association results in the replication cohort, consisting of 211 and 192 subjects with anti-PEG IgM and anti-PEG IgG, respectively, and 596 controls. We identify the immunoglobulin heavy chain (IGH) locus to be associated with anti-PEG IgM response at genome-wide significance (P = 2.23 × 10−22). Our findings may provide novel genetic markers for predicting the immunogenicity of PEG and efficacy of PEGylated therapeutics.
Rapid Staining of Circulating Tumor Cells in Three-Dimensional Microwell Dialysis (3D-μDialysis) Chip
Authors: Cho Wanying , Pradhan Rangadhar , Chen Hsin Ying , Weng Yi-Hsuan , Chu Hsueh Yao , Tseng Fan-Gang , Lin Chien-Ping , Jiang Jeng-Kai 
Published: September 2017

AbstractThe conventional techniques to detect circulating tumour cells (CTCs) are lengthy and the use of centrifugal forces in this technique may cause cell mortality. As the number of CTCs in patients is quite low, the present study aims towards a gentler diagnostic procedure so as not to lose too many CTCs during the sample preparation process. Hence, a Three-Dimensional Microwell dialysis (3D-μDialysis) chip was designed in this study to perform gentle fluorescence-removal process by using dialysis-type flow processes without centrifuging. This leads to a minimum manual handling of CTCs obtained in our study without any contamination. In addition, a rapid staining process which necessitates only about half the time of conventional techniques (35 minutes instead of 90 minutes) is being illustrated by the employment of dialysis process (by dynamically removing water and waste at once) instead of only static diffusion (by statically removing only waste by diffusion). Staining efficiency of our technique is improved over conventional staining because of the flow rate in 3D-μDialysis staining. Moreover, the staining process has been validated with clinical whole blood samples from three TNM stage IV colon cancer patients. The current technique may be termed as “miniature rapid staining and dialysing system”.