bluuebunny/crossref_metadata_2025_split huggingface dataset:
Joint dynamic access points grouping and resource allocation for coordinated transmission in user‐centric UDN
Authors: Wang Chuan'an , Hu Bo , Chen Shanzhi , Wang Yingying 
Published: November 2017

AbstractWe consider the resource allocation problem in user‐centric ultradense network, where each user equipment (UE) is served by its own access points group (APG), and the APG will be dynamically adjusted to support UE's movement. In this context, our scheme is to jointly design dynamic APs grouping and the resource allocation for coordinated transmission in user‐centric ultradense network. First, a user‐centric dynamic APs grouping approach is considered, where the APGs are formed based on cooperation benefits that UEs experience to different access points (APs). Accordingly, due to resource allocation constraints unbounded among the overlapped APGs, which result in the resource allocation optimization problem being nonconvex. To address this issue, the resource allocation problem is divided into the subchannel (SC) allocation subproblem and the power allocation subproblem. With the SC allocation results, an iterative power allocation algorithm is carried out over all SCs at each AP to get an optimal power allocation. The performance of the proposed scheme is also demonstrated through simulations.
Interleukin‐17 and Toll‐like Receptor 10 genetic polymorphisms and susceptibility to large joint osteoarthritis
Authors: Vrgoc Goran , Vrbanec Jurica , Eftedal Randi K. , Dembic Petra L. , Balen Sanja , Dembic Zlatko , Jotanovic Zdravko 
Published: November 2017

ABSTRACTPrimary osteoarthritis (OA) is the most common type of a joint disease. It has a polygenic risk inheritance pattern and affects older people. The etiology of this disease is not fully understood. The aim of this study was to investigate the associations between polymorphisms in pro‐inflammatory interleukin‐17 (IL17A and IL17F) and anti‐inflammatory Toll‐like Receptor 10 (TLR10) genes with the risk for development of advanced stage hip and knee primary OA in the Croatian population. A total of 500 OA patients and 597 controls were genotyped for IL17A SNP (rs2275913), IL17F SNPs (rs763780 and rs1889570), and TLR10 (rs11096957) genes. The allelic and genotypic frequencies of IL17F SNP (rs763780) showed statistically significant differences in comparisons of controls with hip—but not knee—OA patients. The major allele (T) of rs763780 was associated with the lower risk for developing hip OA (p = 7.9 × 10−4, OR = 0.45, 95%CI = 0.27–0.74), whereas the minor allele (C) was associated with susceptibility to hip OA (p = 7.9 × 10−4, OR = 2.24, 95%CI = 1.35–3.72). The genotype T/T was associated with the protection to hip OA (p = 3.9 × 10−4, OR = 0.41, 95%CI = 0.24–0.70), and, lastly, the genotype T/C was associated with the higher risk to acquiring hip OA (p = 2.6 × 10−4, OR = 2.50, 95%CI = 1.47–4.25). TLR10 SNP rs11096957 was found significantly associated with predisposition to hip OA (p = 0.04, OR = 1.41, 95%CI = 1.02–1.94) but not knee OA. Our findings suggest that hip OA in Croatian population might have a different genetic risk regarding the IL17 and TLR10 gene locus than knee OA. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1684–1693, 2018.
Validity of Ultrasound Lung Comets for Assessment of the Severity of Interstitial Pneumonia
Authors: Asano Mariko , Watanabe Hiroyuki , Sato Kazuhiro , Okuda Yuji , Sakamoto Sho , Hasegawa Yukiyasu , Sudo Kazuhisa , Takeda Masahide , Sano Masaaki , Kibira Satoshi , Ito Hiroshi 
Published: November 2017

ObjectivesUltrasound (US) lung comets are often observed in patients with interstitial lung disease or congestive heart failure, but few studies have explored the clinical importance of US lung comets in patients with the former condition. We explored whether the US lung comet number could be used to assess the severity of interstitial pneumonia.MethodsForty stable patients with interstitial pneumonia were examined. Lung comets evident on transthoracic US imaging in 12 selected regions of the posterior chest wall were analyzed. We defined lung comets accompanied by thickened and irregular pleural lines as interstitial US lung comets; these predominated in patients with interstitial pneumonia. The total number of interstitial US lung comets was correlated with the data from chest high‐resolution computed tomography, pulmonary function tests, serologic tests, and the 6‐minute walk test.ResultsThe 40 patients included 16 with idiopathic pulmonary fibrosis and 24 with nonspecific interstitial pneumonia. Thirty‐four patients had interstitial US lung comets, which were more common in the lower than the upper lung area. Good correlations were evident between the lung comet number and the extent of the reticular pattern on chest high‐resolution computed tomography (r = 0.710; P < .01), predicted forced vital capacity (r = −0.614; P < .01), and lung diffusion capacity for carbon monoxide (r = −0.577; P < .01). Notably, the lung comet number had a strong negative correlation with the percutaneous oxygen saturation level after the 6‐minute walk test (r = −0.751; P < .01).ConclusionsThe number of interstitial US lung comets evident on transthoracic US imaging may be a valuable marker of disease severity in patients with interstitial pneumonia.
Somatic mosaicism of an intragenic FANCB duplication in both fibroblast and peripheral blood cells observed in a Fanconi anemia patient leads to milder phenotype
Authors: Asur Rajalakshmi S. , Kimble Danielle C. , Lach Francis P. , Jung Moonjung , Donovan Frank X. , Kamat Aparna , Noonan Raymond J. , Thomas James W. , Park Morgan , Chines Peter , Vlachos Adrianna , Auerbach Arleen D. , Smogorzewska Agata , Chandrasekharappa Settara C. 
Published: November 2017

AbstractBackgroundFanconi anemia (FA) is a rare disorder characterized by congenital malformations, progressive bone marrow failure, and predisposition to cancer. Patients harboring X‐linked FANCB pathogenic variants usually present with severe congenital malformations resembling VACTERL syndrome with hydrocephalus.MethodsWe employed the diepoxybutane (DEB) test for FA diagnosis, arrayCGH for detection of duplication, targeted capture and next‐gen sequencing for defining the duplication breakpoint, PacBio sequencing of full‐length FANCB aberrant transcript, FANCD2 ubiquitination and foci formation assays for the evaluation of FANCB protein function by viral transduction of FANCB‐null cells with lentiviral FANCB WT and mutant expression constructs, and droplet digital PCR for quantitation of the duplication in the genomic DNA and cDNA.ResultsWe describe here an FA‐B patient with a mild phenotype. The DEB diagnostic test for FA revealed somatic mosaicism. We identified a 9154 bp intragenic duplication in FANCB, covering the first coding exon 3 and the flanking regions. A four bp homology (GTAG) present at both ends of the breakpoint is consistent with microhomology‐mediated duplication mechanism. The duplicated allele gives rise to an aberrant transcript containing exon 3 duplication, predicted to introduce a stop codon in FANCB protein (p.A319*). Duplication levels in the peripheral blood DNA declined from 93% to 7.9% in the span of eleven years. Moreover, the patient fibroblasts have shown 8% of wild‐type (WT) allele and his carrier mother showed higher than expected levels of WT allele (79% vs. 50%) in peripheral blood, suggesting that the duplication was highly unstable.ConclusionUnlike sequence point variants, intragenic duplications are difficult to precisely define, accurately quantify, and may be very unstable, challenging the proper diagnosis. The reversion of genomic duplication to the WT allele results in somatic mosaicism and may explain the relatively milder phenotype displayed by the FA‐B patient described here.
Null recurrence and transience of random difference equations in the contractive case
Authors: Alsmeyer Gerold , Buraczewski Dariusz , Iksanov Alexander 
Published: November 2017

Abstract
Given a sequence (Mk, Qk)k ≥ 1 of independent and identically distributed random vectors with nonnegative components, we consider the recursive Markov chain (Xn)n ≥ 0, defined by the random difference equation Xn = MnXn - 1 + Qn for n ≥ 1, where X0 is independent of (Mk, Qk)k ≥ 1. Criteria for the null recurrence/transience are provided in the situation where (Xn)n ≥ 0 is contractive in the sense that M1 ⋯ Mn → 0 almost surely, yet occasional large values of the Qn overcompensate the contractive behavior so that positive recurrence fails to hold. We also investigate the attractor set of (Xn)n ≥ 0 under the sole assumption that this chain is locally contractive and recurrent.
FRAME: femtosecond videography for atomic and molecular dynamics
Authors: Ehn Andreas , Bood Joakim , Li Zheming , Berrocal Edouard , Aldén Marcus , Kristensson Elias 
Published: November 2017

AbstractMany important scientific questions in physics, chemistry and biology require effective methodologies to spectroscopically probe ultrafast intra- and inter-atomic/molecular dynamics. However, current methods that extend into the femtosecond regime are capable of only point measurements or single-snapshot visualizations and thus lack the capability to perform ultrafast spectroscopic videography of dynamic single events. Here we present a laser-probe-based method that enables two-dimensional videography at ultrafast timescales (femtosecond and shorter) of single, non-repetitive events. The method is based on superimposing a structural code onto the illumination to encrypt a single event, which is then deciphered in a post-processing step. This coding strategy enables laser probing with arbitrary wavelengths/bandwidths to collect signals with indiscriminate spectral information, thus allowing for ultrafast videography with full spectroscopic capability. To demonstrate the high temporal resolution of our method, we present videography of light propagation with record high 200 femtosecond temporal resolution. The method is widely applicable for studying a multitude of dynamical processes in physics, chemistry and biology over a wide range of time scales. Because the minimum frame separation (temporal resolution) is dictated by only the laser pulse duration, attosecond-laser technology may further increase video rates by several orders of magnitude.
Stimulus expectation alters decision criterion but not sensory signal in perceptual decision making
Authors: Bang Ji Won , Rahnev Dobromir 
Published: November 2017

AbstractHumans are more likely to report perceiving an expected than an unexpected stimulus. Influential theories have proposed that this bias arises from expectation altering the sensory signal. However, the effects of expectation can also be due to decisional criterion shifts independent of any sensory changes. In order to adjudicate between these two possibilities, we compared the behavioral effects of pre-stimulus cues (pre cues; can influence both sensory signal and decision processes) and post-stimulus cues (post cues; can only influence decision processes). Subjects judged the average orientation of a series of Gabor patches. Surprisingly, we found that post cues had a larger effect on response bias (criterion c) than pre cues. Further, pre and post cues did not differ in their effects on stimulus sensitivity (d’) or the pattern of temporal or feature processing. Indeed, reverse correlation analyses showed no difference in the temporal or feature-based use of information between pre and post cues. Overall, post cues produced all of the behavioral modulations observed as a result of pre cues. These findings show that pre and post cues affect the decision through the same mechanisms and suggest that stimulus expectation alters the decision criterion but not the sensory signal itself.
Electrostatic Map Of Proteasome α-Rings Encodes The Design of Allosteric Porphyrin-Based Inhibitors Able To Affect 20S Conformation By Cooperative Binding
Authors: Dato Antonio Di , Cunsolo Alessandra , Persico Marco , Santoro Anna Maria , D’Urso Alessandro , Milardi Danilo , Purrello Roberto , Stefanelli Manuela , Paolesse Roberto , Tundo Grazia R. , Sbardella Diego , Fattorusso Caterina , Coletta Massimo 
Published: November 2017

AbstractThe importance of allosteric proteasome inhibition in the treatment of cancer is becoming increasingly evident. Motivated by this urgent therapeutic need, we have recently identified cationic porphyrins as a highly versatile class of molecules able to regulate proteasome activity by interfering with gating mechanisms. In the present study, the mapping of electrostatic contacts bridging the regulatory particles with the α-rings of the human 20S proteasome led us to the identification of (meso-tetrakis(4-N-methylphenyl pyridyl)-porphyrin (pTMPyPP4) as a novel non-competitive inhibitor of human 20S proteasome. pTMPyPP4 inhibition mechanism implies a positive cooperative binding to proteasome, which disappears when a permanently open proteasome mutant (α-3ΔN) is used, supporting the hypothesis that the events associated with allosteric proteasome inhibition by pTMPyPP4 interfere with 20S gating and affect its “open-closed” equilibrium. Therefore, we propose that the spatial distribution of the negatively charged residues responsible for the interaction with regulatory particles at the α-ring surface of human 20S may be exploited as a blueprint for the design of allosteric proteasome regulators.
Interplay between global and pathway-specific synaptic plasticity in CA1 pyramidal cells
Authors: Berberich Sven , Pohle Jörg , Pollard Marie , Barroso-Flores Janet , Köhr Georg 
Published: November 2017

AbstractMechanisms underlying information storage have been depicted for global cell-wide and pathway-specific synaptic plasticity. Yet, little is known how these forms of plasticity interact to enhance synaptic competition and network stability. We examined synaptic interactions between apical and basal dendrites of CA1 pyramidal neurons in mouse hippocampal slices. Bursts (50 Hz) of three action potentials (AP-bursts) paired with preceding presynaptic stimulation in stratum radiatum specifically led to LTP of the paired pathway in adult mice (P75). At adolescence (P28), an increase in burst frequency (>50 Hz) was required to gain timing-dependent LTP. Surprisingly, paired radiatum and unpaired oriens pathway potentiated, unless the pre-post delay was shortened from 10 to 5 ms, which selectively potentiated paired radiatum pathway, since unpaired oriens pathway decreased back to baseline. Conversely, the exact same 5 ms pairing in stratum oriens potentiated both pathways, as did AP-bursts alone, which potentiated synaptic efficacy as well as current-evoked postsynaptic spiking. L-type voltage-gated Ca2+ channels were involved in mediating synaptic potentiation in oriens, whereas NMDA and adenosine receptors counteracted unpaired stratum oriens potentiation following pairing in stratum radiatum. This asymmetric plasticity uncovers important insights into alterations of synaptic efficacy and intrinsic neuronal excitability for pathways that convey hippocampal and extra-hippocampal information.
The Genetic Spectrum of Familial Hypercholesterolemia (FH) in the Iranian Population
Authors: Fairoozy R. H. , Futema M. , Vakili R. , Abbaszadegan M. R. , Hosseini S. , Aminzadeh M. , Zaeri H. , Mobini M. , Humphries S. E. , Sahebkar A. 
Published: November 2017

AbstractFamilial hypercholesterolemia (FH) is an autosomal dominant disorder associated with premature cardiovascular disease (CVD). Mutations in the LDLR, APOB, and PCSK9 genes are known to cause FH. In this study, we analysed the genetic spectrum of the disease in subjects from the Iranian population with a clinical diagnosis of FH. Samples were collected from 16 children and family members from five different cities of Iran. Probands were screened for mutations in the LDLR, APOB, and PCSK9 genes using next generation sequencing, with results confirmed by Sanger sequencing. The likely pathology of identified variants was examined using in silico tools. Of the probands, 14 had a clinical diagnosis of homozygous FH and two of heterozygous FH. No mutations were found in either APOB or PCSK9, but nine probands were homozygous for seven different LDLR mutations, with p.(Trp577Arg) occurring in three and p.Val806Glyfs*11 occurring in two patients. Two mutations were novel: p.(Leu479Gln) and p.(Glu668*). Seven probands with a clinical diagnosis of FH were mutation negative. This pilot study, integrating clinical and molecular-based techniques, begins to elucidate the FH heterogeneity and the mutation spectrum in the Iranian population. Such information is important for future disease management and cost savings.
Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis
Authors: Dias-Teixeira Karina Luiza , Calegari-Silva Teresa C. , Medina Jorge M. , Vivarini Áislan C. , Cavalcanti Átila , Teteo Nataly , Santana Alynne Karen M. , Real Fernando , Gomes Ciro M. , Pereira Renata Meirelles Santos , Fasel Nicolas , Silva João S. , Aktas Bertal H. , Lopes Ulisses G. 
Published: November 2017

AbstractLeishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is activated by Leishmania and this pathway is important for Leishmania amazonensis infection. Knocking down PERK or ATF4 expression or inhibiting PERK kinase activity diminished L. amazonensis infection. Knocking down ATF4 decreased NRF2 expression and its nuclear translocation, reduced HO-1 expression and increased nitric oxide production. Meanwhile, the increased expression of ATF4 and HO-1 mRNAs were observed in lesions derived from patients infected with the prevalent related species L.(V.) braziliensis. Our data demonstrates that Leishmania parasites activate the PERK/eIF2α/ATF-4 pathway in cultured macrophages and infected human tissue and that this pathway is important for parasite survival and progression of the infection.
NSD1 inactivation defines an immune cold, DNA hypomethylated subtype in squamous cell carcinoma
Authors: Brennan Kevin , Shin June Ho , Tay Joshua K. , Prunello Marcos , Gentles Andrew J. , Sunwoo John B. , Gevaert Olivier 
Published: November 2017

AbstractChromatin modifying enzymes are frequently mutated in cancer, resulting in widespread epigenetic deregulation. Recent reports indicate that inactivating mutations in the histone methyltransferase NSD1 define an intrinsic subtype of head and neck squamous cell carcinoma (HNSC) that features pronounced DNA hypomethylation. Here, we describe a similar hypomethylated subtype of lung squamous cell carcinoma (LUSC) that is enriched for both inactivating mutations and deletions inNSD1. The ‘NSD1 subtypes’ of HNSC and LUSC are highly correlated at the DNA methylation and gene expression levels, featuring ectopic expression of developmental transcription factors and genes that are also hypomethylated in Sotos syndrome, a congenital disorder caused by germlineNSD1mutations. Further, the NSD1 subtype of HNSC displays an ‘immune cold’ phenotype characterized by low infiltration of tumor-associated leukocytes, particularly macrophages and CD8+T cells, as well as low expression of genes encoding the immunotherapy target PD-1 immune checkpoint receptor and its ligands. Using anin vivomodel, we demonstrate that NSD1 inactivation results in reduced T cell infiltration into the tumor microenvironment, implicating NSD1 as a tumor cell-intrinsic driver of an immune cold phenotype. NSD1 inactivation therefore causes epigenetic deregulation across cancer sites, and has implications for immunotherapy.
Preparation of Permanent Magnetic Resin Crosslinking by Diallyl Itaconate and Its Adsorptive and Anti-fouling Behaviors for Humic Acid Removal
Authors: Li Qimeng , Wu Ji , Hua Ming , Zhang Guang , Li Wentao , Shuang Chendong , Li Aimin 
Published: November 2017

AbstractIn this research, a series of permanent magnetic anion exchange resins (MAERs) were prepared by polymerizing glycidyl methacrylate monomer and crosslinking diallyl itaconate (DAI) and divinylbenzene. The properties and performances of these novel MAERs were systematically characterized and evaluated for humic acid (HA) adsorption by batch experiments. With the increase of DAI content from 0 to 15%, the moisture of MAERs was elevated from 50.23% to 68.53%, along with the adsorption capacity increasing from 2.57 to 3.14 mmol g−1. As the concentrations of co-existing cation (Ca2+ and Mg2+) increased, the adsorption amounts of HA dropped drastically at first and increased a little at high cation concentrations. Although ion exchange was the primary mechanism for HA adsorption, other physical interactions and electrostatic attraction between HA molecules and newly formed oxonium group also played significant roles for HA adsorption. The MAERs could be efficiently regenerated by a mixture of NaCl/NaOH solution (10%/1%), and notably, the MAER-3 with the highest DAI content displayed unapparent loss of adsorption capacity during twenty-one successive adsorption-desorption cycles. These results suggested a novel resin adsorbent for its excellent performances on adsorption, regeneration, and sedimentation in water treatment for natural organic matter removal.
First-principles study of nonmetal doped monolayer MoSe2 for tunable electronic and photocatalytic properties
Authors: Zhao Yafei , Wang Wei , Li Can , He Liang 
Published: November 2017

AbstractRecently, two dimensional transition metal dichalcogenides become popular research topics because of their unique crystal and electronic structure. In this work, the geometrical structure, electronic, electrical transport, redox potentials and photocatalytic properties of nonmetal (H, B, C, Si, N, P, As, O, S, Te, F, Cl, Br and I) doped monolayer MoSe2 were investigated by first principle calculations. The binding energy indicates that nonmetal doped MoSe2 are energetically favorable compared to Se vacancies, except B- and C-doped. We have found that nonmetal dopants with an even number of valence electrons doped MoSe2 have p-type conductivity. On the contrary, nonmetal dopants with an odd number of valence electrons doped MoSe2 have p-type or n-type conductivity; and they have better photocatalytic performance.
Double-Layer Reconstruction of the Achilles’ Tendon Using a Modified Lindholm's Technique and Vascularized Fascia Lata
Authors: Kelahmetoglu Osman , Gules Mustafa , Elmadag Nuh , Guneren Ethem , Sonmez Ergun Selma 
Published: November 2017

AbstractLoss of the Achilles’ tendon with overlying soft tissue and skin defects remains a complex reconstructive challenge. Herein we present our experience using a free composite anterolateral thigh (ALT) flap with vascularized fascia lata and a modified Lindholm's technique to repair the Achilles’ tendon. A 37-year-old man suffered from tertiary Achilles’ tendon rupture. For reconstruction, the free composite ALT flap with vascularized fascia lata was used to wrap Achilles’ tendon. A modified Lindholm's technique was used to cover overlying soft tissue defects. The patient was followed up for 12 months. No wound healing problems were reported, and the patient was able to walk and return to his daily ambulating activities without any support after 5 months postoperatively. This technique may be useful to achieve satisfactory outcomes in patients with ruptured Achilles’ tendons following tertiary repair.