bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy and Safety of Cell-Assisted Acellular Adipose Matrix Transfer for Volume Retention and Regeneration Compared to Hyaluronic Acid Filler Injection
Authors: Jin Xian , Yoo Hyokyung , Tran Vinh Vuong The , Yi Chenggang , Hong Ki Yong , Chang Hak 
Published: October 2024

Abstract
Background
Cell-assisted acellular adipose matrix (AAM) transfer is a novel technique for soft tissue volume restoration, where AAM acts as a scaffold for tissue proliferation and promotes host cell migration, vascularization, and adipogenesis. This study aimed to evaluate the efficacy and safety of in vivo cell-assisted AAM transfer compared to hyaluronic acid (HA) filler injection.

Methods
Human adipose tissue was used to manufacture AAM, and murine adipose-derived stem cells (ASCs) were prepared. Nude mice were divided into four groups: AAM transfer (AT), ASC-assisted AAM transfer (CAT), HA filler injection (HI), and ASC-assisted HA filler injection (CHI). Eight weeks post-transfer, in vivo graft volume/weight, histology, and gene expression were analyzed to assess efficacy and safety.

Results
The AAM retained its three-dimensional scaffold structure without cellular components. AT/CAT showed lower volume retention than HA/CHA; however, CAT maintained a similar volume to HA. Histologically, adipogenesis and collagen formation were increased in AT/CAT compared to HA/CHA, with CAT showing the highest levels. CAT also demonstrated superior angiogenesis, adipogenesis, and gene expression (Vegf and Pparg), along with lower Il-6 expression, higher Il-10 expression, and reduced capsule formation, indicating better biocompatibility.

Conclusions
Cell-assisted AAM transfer is a promising technique for volume retention and tissue regeneration, offering a safe and effective alternative to HA filler injections.

Level of Evidence III
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
A multi-docking strategy for robotic LAR and deep pelvic surgery with the Hugo RAS system: experience from a tertiary referral center
Authors: Rottoli Matteo , Violante Tommaso , Calini Giacomo , Cardelli Stefano , Novelli Marco , Poggioli Gilberto 
Published: October 2024

Abstract
Introduction
In June 2023, our institution adopted the Medtronic Hugo RAS system for colorectal procedures. This system’s independent robotic arms enable personalized docking configurations. This study presents our refined multi-docking strategy for robotic low anterior resection (LAR) and deep pelvic procedures, designed to maximize the Hugo RAS system’s potential in rectal surgery, and evaluates the associated learning curve.

Methods
This retrospective analysis included 31 robotic LAR procedures performed with the Hugo RAS system using our novel multi-docking strategy. Docking times were the primary outcome. The Mann–Kendall test, Spearman’s correlation, and cumulative sum (CUSUM) analysis were used to assess the learning curve and efficiency gains associated with the strategy.

Results
Docking times showed a significant negative trend (p < 0.01), indicating improved efficiency with experience. CUSUM analysis confirmed a distinct learning curve, with proficiency achieved around the 15th procedure. The median docking time was 6 min, comparable to other robotic platforms after proficiency.

Conclusion
This study demonstrates the feasibility and effectiveness of a multi-docking strategy in robotic LAR using the Hugo RAS system. Our personalized approach, capitalizing on the system’s unique features, resulted in efficient docking times and streamlined surgical workflow. This approach may be particularly beneficial for surgeons transitioning from laparoscopic to robotic surgery, facilitating a smoother adoption of the new technology. Further research is needed to validate the generalizability of these findings across different surgical settings and experience levels.
Psoriasis localization patterns in the Swiss Psoriasis Registry (SDNTT) over 11 years: an analysis by sex and age
Authors: Birkenmaier Ion , Maul Lara Valeska , Oyanguren Iker , Sorbe Christina , Fröhlich Fabienne , Schlapbach Christoph , Heidemeyer Kristine , Yawalkar Nikhil , Boehncke Wolf-Henning , Ring Hans-Christian , Thyssen Jacob P. , Egeberg Alexander , Micheroli Raphael , Thomsen Simon Francis , Mainetti Carlo , Cozzio Antonio , Kündig Thomas M. , Levesque Mitchell P. , Navarini Alexander , Maul Julia-Tatjana 
Published: October 2024

AbstractReal-world data on anatomically localized psoriasis and its response to systemic therapy across different age-groups and sexes is limited. This study aimed to evaluate the severity and distribution of psoriasis over time in female and male patients receiving systemic therapies, categorized by age within the Swiss psoriasis registry (SDNTT). Patient-data was obtained over 11 years through the SDNTT. The localized Psoriasis Area and Severity Index (locPASI) of the head, trunk, upper and lower extremities was analyzed over two years following the start of systemic non-/biologic treatment. A total of 316 female and 517 male patients were analyzed. Male patients had a higher baseline locPASI for legs, trunk and arms (p < 0.001), but not for the head (p = 0.961). The locPASI for the head in younger female patients (18–40 years) had a higher score than those aged 55 + (p = 0.022) and after two years, middle aged (41–54) showed a lower score compared to younger patients (p = 0.045). Younger male patients revealed a lower score after two years of therapy in the leg- and arm-area compared to older (p = 0.018 and p = 0.048, respectively). Female patients on non-biologics had a fast initial response, converging with male patients’ scores over 24 months. Over 75% locPASI reduction was observed for female head-area (81.4%), male trunk (82.7%) and legs (76.1%). Absolute locPASI ≤ 2 was achieved 3–6 months for all locations with interleukin (IL)-17, IL-12/23 and IL-23-inhibitors, except for the legs of male patients on anti-IL-17 and female patients on anti-IL-12/23 and -IL-23. After two years, male patients did not achieve a locPASI ≤ 2 for any biologic-treatment in the legs, nor for the arms on anti-TNF-α. Significant disparities in localized PASI were observed between female and male patients. The age, sex and severity of distinct localizations should be considered to optimize treatment goals.
Detection of Alport gene variants in children and young people with persistent haematuria
Authors: Ng Natasha Su Lynn , Yamamura Tomohiko , Shenoy Mohan , Stuart Helen M. , Lennon Rachel 
Published: October 2024

Abstract

Background
Genetic kidney disease is an important cause of persistent microscopic haematuria in children and young people. We aimed to determine the frequency of variants in the Alport syndrome genes (COL4A3, COL4A4 or COL4A5) in individuals under 18 years of age presenting with persistent microscopic haematuria to a single specialist centre in the UK over a 10-year period.

Methods
We conducted a retrospective longitudinal study of individuals referred to a tertiary paediatric nephrology service with persistent microscopic haematuria between April 2012 to 2022.

Results
A total of 224 individuals (female 51.8%) were evaluated with persistent microscopic haematuria of greater than 6 months duration. The age at presentation was 7.5 ± 4.3 years (mean ± SD) with a duration of follow-up of 6.8 ± 4.6 years (mean ± SD). Targeted exome sequencing was performed in 134 individuals and 91 (68%) had a pathogenic or likely pathogenic variant in COL4A3, COL4A4 or COL4A5. Only 49.5% of individuals with identified variants had a family history of microscopic haematuria documented and 37.4% (34/91) had additional proteinuria at presentation. COL4A5 was the most common gene affected and missense variants affecting glycine residues were the most common variant type.

Conclusion
Over two-thirds of children and young people who underwent genetic testing had an identifiable genetic basis for their microscopic haematuria and over half did not have a documented family history. Genetic testing should be part of the evaluation of persistent microscopic haematuria despite a negative family history.

Graphical abstract
Complications and failure after Kock continent ileostomy: A systematic review and meta-analysis
Authors: Emile S. H. , Garoufalia Z. , Mavrantonis S. , Rogers P. , Barsom S. H. , Horesh N. , Gefen R. , Wexner S. D. 
Published: October 2024

Abstract
Background
A significant number of patients experience complications of the Kock pouch (KP) warranting revision or excision. This systematic review aimed to assess the pooled prevalence and risk factors for complications and failure of the KP.

Methods
This Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA)-compliant systematic review (CRD42023416961) searched PubMed, Scopus, and Web of Science for studies on adult patients with Kock continent ileostomy published after the year 2000. The main outcome measures were revision, complications, and failure of the KP. Risk factors for complications and failure were assessed using a meta-regression analysis. Risk of bias was assessed using the ROBINS-1 tool. A proportional meta-analysis of the main outcomes was performed.

Results
A total of 19 studies (2042 patients) were included. The weighted mean prevalence of complications was 60.4% [95% confidence interval (CI): 46.1–74.7%], of pouch revision was 46.6% (95% CI: 38.5–54.7%), and of pouch failure was 12.9% (95% CI: 9.3–16.4%). Studies conducted in the USA had a mean failure prevalence of 12.6% (95% CI: 6.2–18.9%) comparable to studies conducted in Europe (11.1%; 95% CI: 7.5–14.7%). Factors associated with higher complications were increased body mass index (BMI) and previous ileoanal pouch anastomosis (IPAA); however, these factors were not associated with increased pouch failure.

Conclusions
The KP is a highly complex operation as shown by a pooled complication prevalence of 60%, and thus, it should be only performed by experienced surgeons. Despite the high prevalence of complications and need for revisional surgery, patients are keen to preserve their KP. Increased BMI and a previous failed IPAA are risk factors for pouch complications, but not failure.
Divisible convex sets with properly embedded cones
Authors: Blayac Pierre-Louis , Viaggi Gabriele 
Published: October 2024

AbstractIn this article we construct many examples of properly convex irreducible domains divided by Zariski dense relatively hyperbolic groups in every dimension at least 3. This answers a question of Benoist. Relative hyperbolicity and non-strict convexity are captured by a family of properly embedded cones (convex hulls of points and ellipsoids) in the domain. Our construction is most flexible in dimension 3 where we give a purely topological criterion for the existence of a large deformation space of geometrically controlled convex projective structures with totally geodesic boundary on a compact 3-manifold.
Zyklusgebundene Anfälle der Frau
Authors: Müffelmann Birgitt 
Published: October 2024

ZusammenfassungViele Frauen mit Epilepsie berichten in der neurologischen Sprechstunde oder in einer Epilepsieambulanz von einer Zyklusbindung ihrer Anfälle. Anfallscluster im Rahmen des Menstruationszyklus bezeichnet man als katameniale Anfallshäufung bzw. katameniale Epilepsie. Zyklusbedingte Hormonschwankungen sind unstrittig. Aber welcher Einfluss auf die Anfallssituation ist gesichert, und was bedeutet das für die Beratung? Dieser Beitrag gibt anhand der aktuellen Literatur einen Überblick über den aktuellen Kenntnisstand, therapeutische Möglichkeiten und Empfehlungen für die Praxis.
A biological age based on common clinical markers predicts health trajectory and mortality risk in dogs
Authors: Herzig Sébastien , Zollinger Alix , Texari Lorane , Holzwarth James A. , Middleton Rondo P. , Pan Yuanlong , Steiner Pascal , Gut Philipp 
Published: October 2024

AbstractPredicting aging trajectories through biomarkers of biological aging can guide interventions that optimize healthy lifespan in humans and companion animals. Differences in physiology, genetics, nutrition, and lifestyle limit the generalization of such biomarkers and may therefore require species-specific algorithms. Here, we compared correlations of standard clinical blood parameters with survival probability in humans with those of the two most common mammalian companion animals, cats and dogs, and highlighted universal and species-specific relationships. Based on this comparative analysis, we generated and validated an algorithm that predicts biological age in canines using a longitudinal dataset with health records, blood count, and clinical chemistry from 829 dogs spanning over 12 years. Positive deviations of biological from chronological age (AgeDev) measured by this composite score significantly correlated with a decreased survival probability (hazard ratio = 1.75 per 1 year of AgeDev, p = 3.7e − 06). Importantly, in nearly half of the dogs whose biological age was accelerated by more than 1 year, none or only a single individual marker scored outside its respective reference range, suggesting practical applications for the detection of unfavorable health trajectories. Analyzing samples from a unique 14-year life-long diet restriction study, we show that restricted caloric intake lowers biological age, an effect that can be quantified at midlife years before a difference in survival is observed. Thus, a biological age clock based on clinical blood tests predicts the health trajectories of dogs for use in research and veterinary practice.
A Monte Carlo study comparing dead-time losses of a gamma camera between tungsten functional paper and lead sheet for dosimetry in targeted radionuclide therapy with Lu-177
Authors: Nakanishi Kohei , Fujita Naotoshi , Iwanaga Haruna , Asano Yuki , Abe Shinji , Nishii Ryuichi , Kato Katsuhiko 
Published: October 2024

Abstract

Objective
Dead-time loss is reported to be non-negligible for some patients with a high tumor burden in Lu-177 radionuclide therapy, even if the administered activity is 7.4 GBq. Hence, we proposed a simple method to shorten the apparent dead time and reduce dead-time loss using a thin lead sheet in previous work. The collimator surface of the gamma camera was covered with a lead sheet in our proposed method. While allowing the detection of 208-keV gamma photons of Lu-177 that penetrate the sheet, photons with energies lower than 208 keV, which cause dead-time loss, were shielded. In this study, we evaluated the usefulness of tungsten functional paper (TFP) for the proposed method using Monte Carlo simulation.

Methods
The count rates in imaging of Lu-177 administered to patients were simulated with the International Commission on Radiological Protection (ICRP) 110 phantom using the GATE Monte Carlo simulation toolkit. The simulated gamma cameras with a 0.5-mm lead sheet, 1.2-mm TFP, or no filter were positioned closely on the anterior and posterior sides of the phantom. The apparent dead times and dead-time losses at 24 h after administration were calculated for an energy window of 208 keV ± 10%. Moreover, the dead-time losses at 24–120 h were analytically assessed using activity excretion data of Lu-177-DOTATATE.

Results
The dead-time loss without a filter was 5% even 120 h after administration in patients with a high tumor burden and slow excretion, while those with a lead sheet and TFP were 0.22 and 0.58 times less than those with no filter, respectively. The count rates with the TFP were 1.3 times higher than those with the lead sheet, and the TFP could maintain primary count rates at 91–94% of those without a filter.

Conclusions
Although the apparent dead time and dead-time loss with the lead sheet were shorter and less than those with TFP, those with TFP were superior to those without a filter. The advantage of TFP over the lead sheet is that the decrease in primary count rates was less.
Thrombose-Prophylaxe einer Thrombembolie
Authors: Binder Barbara 
Published: October 2024

ZusammenfassungThrombembolische Ereignisse können die Lebensqualität von Patienten stark einschränken und im schlimmsten Fall fatal enden. Das Risiko solcher Ereignisse maximal zu minimieren ist das Ziel. Wichtig für den Praxisalltag sind das Ab‑/Einschätzen des thrombembolischen Risikos betreffend die aktuelle Situation der Patienten. Chirurgische Eingriffe, krankheitsbedingte Reduktion der Mobilität wie auch Tumorerkrankungen und vor allem persönliche Anamnese stellen die Eckpfeiler für die Indikation einer Prophylaxe von thrombembolischen Erkrankungen dar.
Through-Window Home Aerial Delivery System with In-Flight Parcel Load and Handover: Design and Validation in Indoor Scenario
Authors: Suarez Alejandro , Gonzalez Antonio , Alvarez Carlos , Ollero Anibal 
Published: October 2024

Abstract
This paper presents the design, development, and validation in indoor scenario of an aerial delivery system intended to conduct the delivery of light parcels directly to the user through the window of his/her home, motivated by the convenience of facilitating the access to medicines to people with reduced mobility.The system consists of a fully-actuated multi-rotor (FAMR) equipped with a front basket where the parcel to be delivered is loaded by a lightweight and compliant anthropomorphic dual arm system (LiCAS) located at the supply point, using one of the arms to drop the parcel in the basket while the other arm holds its base to support the sudden moment exerted at the FAMR. The paper analyses four types of physical interactions raised during the operation on flight: (1) sudden changes in the mass distribution of the FAMR during the load/unload phase, affecting the multi-rotor position-attitude controllers, (2) impact and impulsive forces exerted by the human on the FAMR to demonstrate the reliability and robustness of conventional cascade controllers, (3) passive accommodation of the LiCAS while holding the FAMR during the parcel load, relying on the mechanical joint compliance, and (4) compliant human–FAMR interaction, interpreting the multi-rotor pose control error as a Cartesian/angular deflection to implement an admittance controller that allows the user guiding the platform. Experimental results allow the identification and characterization of these effects for different payload masses. The execution of the complete operation, involving the parcel load with the LiCAS and handover by the user through a window, is validated in a representative indoor scenario.

Graphical Abstract
Ethics, Mindfulness, and Consciousness: A Study of Their Relation in Early Buddhism
Authors: Shulman Eviatar 
Published: October 2024

AbstractScholarly discussions of mindfulness normally treat the term as reflecting a specific, independent, psychological function. Here, mindfulness is placed within a broader understanding of the Buddhist cultivation of consciousness, with special attention to the ethical aspects of mindfulness. Focusing on sources from early Buddhism, the article demonstrates how ethics was thought to have a positive, indeed a necessary, effect on a successful practice of mindfulness. The article moves beyond the Sati-paṭṭhāna-sutta (“The Foundations of Mindfulness”), which has been emphasized in scholarship, to related texts in the Middle Length Discourses (Majjhima-Nikāya) and beyond them to other Pāli sources. Here, we learn that “You should cultivate the four applications of mindfulness based on ethics, established in ethics.” While the emphasis on ethics in these sources reminds us of the conceptual dimensions of mindfulness, it also allows scholars to see both ethics and mindfulness as partaking in the broader attempt to enrich consciousness and make it healthier, softer, and more lucid. Buddhist practice works to change the structures of subjectivity and make them more conducive to liberation, in whatever way it may be defined. Thus, the Buddhist contemplative tradition can be seen to participate in an effort to change the quality of consciousness, rather than being a mere attempt to reach an annihilation of “suffering.” These considerations allow us to see mindfulness as a form of ethical activity in itself.
Pedicled Anterolateral Thigh Flap (ALT) for Vulva Reconstruction: Journey to a New Horizon
Authors: Begum Dimpy , Barmon Debabrata , Baruah Upasana , Darak Shruti , Aparajita R. , Kumar Mahendra , Bassetty Karthik Chandra 
Published: October 2024

AbstractSurgery for vulval malignancies necessitates extensive resection necessitating the use of musculocutaneous grafts. We present one such case where the patient needed both a V–Y plasty and an anterolateral thigh flap to ensure a tension-free repair. She underwent a partial deep vulvectomy followed by V–Y plasty and ALT flap. The procedure has been described in detail along with intraoperative photographs. She recovered uneventfully and is receiving post-operative adjuvant radiotherapy. We would like to highlight this “additional skill” of plastic surgery which will empower surgeons to undertake radical surgeries to ensure the best outcomes for patients.
Comparison of laparoscopic hepatectomy and radiofrequency ablation for small hepatocellular carcinoma patients: a SEER population-based propensity score matching study
Authors: Wang Xi , Chai Xinqun , Tang Ruiya , Xu Yunjie , Chen Qinjunjie 
Published: October 2024

AbstractThis study was designed to compare the efficacy of laparoscopic hepatectomy (LH) and radiofrequency ablation (RFA) in terms of their therapeutic effect on small hepatocellular carcinoma (SHCC). The SEER database was employed to integrate SHCC patients who had received treatment with either LH (n = 1132) or RFA (n = 797). The LH group (n = 623) and the RFA group (n = 623) were matched with 1:1 propensity score matching (PSM) in order to reduce the possibility of selection bias. The Kaplan–Meier method and Cox proportional hazards regression method were employed to ascertain the prognostic factors associated with overall survival (OS) and disease-specific survival (DSS). Both before and after PSM, the 1, 3 and 5-years OS and DSS were significantly higher in the LH groups compared to the RFA group. Besides, for SHCC with tumor size ≤ 2cm (n = 418), even P values not reaching statistical significance, the survival curves were compatible with a superiority of LH over RFA for OS and DSS in overall (P = 0.054 and P = 0.077), primary SHCC (P = 0.110 and P = 0.058) and recurrent SHCC (P = 0.068 and P = 1.000) cohorts. In contrast, for SHCC with tumor size between 2 and 3 cm (n = 828), LH group always had a better OS and DSS in the all cohorts (all P < 0.05). In addition, higher AFP level, poor differentiation grade, recurrent tumor and treatment type were independent prognostic factors for OS, while poor differentiation grade, larger tumor size and treatment type were the independent prognostic factors for DSS (all P < 0.05). LH was associated with better OS and DSS than RFA in SHCC patients. Even in tumor size ≤ 2 cm, LH still should be the first choice as its long-term survival benefits.