bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deep learning models for forecasting electricity demand in green low-carbon supply chains
Authors: Chen Yu , Liu Chang , Ge Junping , Wu Jianfeng , Zhao Xin , Gao Zhan 
Published: September 2024

Abstract
In response to the requirements of the green and low-carbon demands in the electricity supply chain, it is crucial to propose effective demand forecasting models to balance supply and demand of electrical materials and enhance operational efficiency. This paper introduces a combined forecasting model Seasonal Autoregressive Integrated Moving Average (SARIMA)-BP. The SARIMA-BP hybrid forecasting model enhances prediction accuracy by leveraging Autoregressive Integrated Moving Average (ARIMA) for initial forecasting and using its results as input features for BP neural networks (BPNN) to further refine the forecasts. Using various electrical materials in power projects as examples, the model verifies the accuracy of demand forecasts by comparing predicted quantities with actual demands. Furthermore, the model's performance superiority is ensured through comparison with results from other forecasting models. In the demand forecasting for steel-core aluminum stranded wire, the Mean Absolute Percentage Error (MAPE) value of the combined forecasting model is 9.8%, surpassing that of the other two models. This integrated approach not only meets the intricate forecasting demands of the electricity industry but also aids in optimizing resource allocation and improving operational efficiency, thereby reducing costs and achieving low-carbon sustainable development in the electricity sector.
poxtA amplification and mutations in 23S rRNA confer enhanced linezolid resistance in Enterococcus faecalis
Authors: Shan Xinxin , Li Chenglong , Zhang Likuan , Zou Chenhui , Yu Runhao , Schwarz Stefan , Shang Yanhong , Li Dexi , Brenciani Andrea , Du Xiang-Dang 
Published: September 2024

Abstract

Objectives
This study aimed to explore the evolutionary patterns and resistance mechanisms of an Enterococcus faecalis strain harbouring poxtA under linezolid exposure.

Methods
A poxtA-carrying E. faecalis electrotransformant DJH702 with a linezolid minimum inhibitory concentration of 4 mg/L was exposed to increasing concentrations of linezolid (8–64 mg/L). The derived strains growing at 8, 16, 32 and 64 mg/L, designed DJH702_8, DJH702_16, DJH702_32 and DJH702_64, were obtained. The amplification and overexpression of poxtA were measured using sequencing and RT–PCR, the fitness cost by competition assays and the stability of the repeat units by serial passage.

Results
In all derived strains, high-level linezolid resistance develops through poxtA amplification. The relative copy numbers and transcription levels of poxtA were significantly increased. However, in the presence of higher linezolid concentrations, DJH702_32 and DJH702_64 showed reduced poxtA copy numbers and transcription levels compared with DJH702_8 and DJH702_16, but additional mutations in the 23S rRNA (G2505A). IS1216E-mediated formation of translocatable units with subsequent tandem amplification of these translocatable units supported the gain of poxtA segments. However, these amplicons were not stable and were lost frequently in the absence of a linezolid selection pressure. The amplification of the poxtA region did not result in a fitness cost, but mutations in 23S rRNA did.

Conclusions
poxtA-carrying E. faecalis electrotransformants used two distinct mechanisms to resist linezolid selection pressure: at lower concentrations, strains prioritized increasing poxtA expression levels, while at higher concentrations, a combination of increased poxtA expression and mutations in 23S rRNA was observed.
Genomic characterization of antibiotic-resistant Staphylococcus epidermidis with observed shifts in optimal temperature
Authors: Boyd Sada M , Chacon-Barahona Jonathan A , Mira Portia , Dey Debayan , Chun Devyn , Xue Carolyn , Pulido Sophia , Yeh Pamela 
Published: September 2024

Abstract

Aims
Antibiotic resistance genes (ARGs) in the environment pose significant public health concerns and are influenced by conditions like temperature changes. We previously observed that resistance evolution to gentamicin and colistin affects optimal growth temperatures in Staphylococcus epidermidis isolates. Despite significant phenotype observations, the genetic basis remains unclear. We aim to identify the genetic changes linked to antibiotic resistance evolution that alter optimal growth temperature.

Methods and results
Using whole-genome sequencing, we sequenced the genomes of gentamicin-resistant (GEN-1, GEN-2) and colistin-resistant (COL-4, COL-6) S. epidermidis isolates. Variant analysis with the BV-BRC bioinformatics tool identified genes involved in antibiotic resistance and temperature response. We found 12 genetic variants, including two unique to GEN-2 and one in COL-4. One shared mutation was observed in GEN-1 and GEN-2, and another in COL-4 and COL-6. Five mutations were shared among all isolates related to mobile gene elements, including a transposase IS4 family, two putative transposases, and two transposase-like insertion elements.

Conclusions
Our findings indicate that the same genes involved in gentamicin and colistin resistance, especially those related to mobile genetic elements, may also play a crucial role in temperature response.
Effect of supplementing algae to breeding and early gestation first calf heifers on growth and reproduction
Authors: Nicholls Griffin T , Funnell Bethany J , Stewart Kara R , Lemenager Ronald P , Briggs Nathan G , Schoonmaker Jon P 
Published: September 2024

Abstract
Fat supplementation has potential to improve reproductive performance and increase pregnancy rates in cattle by increasing the energy density of the diet. However, some of the positive effects of fat seem to be influenced by the type of fatty acid fed. Docosahexaenoic acid (DHA, 22:6n-3) and eicosapentaenoic acid (EPA, 20:5n-3) are long-chain n-3 poly-unsaturated fatty acids (PUFA) that have important biological effects on reproduction through their involvement in hormone and series 3 prostaglandin synthesis. Ruminant tissues are naturally almost devoid of n-3 long-chain PUFA, specifically EPA and DHA. Algae biomass provides a consistent source of DHA and EPA that could be fed to alter hormonal profiles and improve reproduction of beef heifers. Eighty-eight Angus × Simmental heifers (427 ± 1.8 kg body weight [BW]) were blocked by BW and allotted to 2 treatments (44/treatment, 4 pens/treatment, 11 heifers/pen). Control heifers were fed a diet that contained (dry matter [DM] basis) 52.8% mixed grass silage, 32% corn silage, and 15.2% concentrate. DHAgold (49% fat; 21.8% DHA; DSM Inc.) was included in the algae diet at 1.65% DM, replacing equal parts of corn and DDGS. Diets were formulated to contain 12% crude protein and 0.85 Mcal/kg net energy for gain (NEg). Heifers were fed treatment diets from 54 d prior to the breeding season through the first trimester. Follicular fluid was collected on day 47 for hormonal analysis. Artificial insemination (AI) was from days 54 to 77. Heifers that did not get pregnant to AI were removed from the study on day 109 and placed with a bull. The study ended on day 180. Data were analyzed using the MIXED procedure of SAS. During the pre-breeding period, algae heifers had lesser dry matter intake (P = 0.006) compared to control heifers. Heifers supplemented with algae had a greater average daily gain (P = 0.03) during the breeding period and BW tended (P = 0.06) to be greater for algae compared to control heifers on day 98 and was greater on day 180 (P = 0.03). Dominant follicle diameter and follicular estrogen concentration were unaffected by treatment (P ≥ 0.12). Follicular insulin-like growth factor-1 was greater in algae compared to control heifers (P = 0.03). First service conception rate did not differ between treatments (P = 0.67); however, second service and overall conception were lesser (P ≤ 0.03) in algae compared to control heifers. These data suggest supplementing DHA-rich algae improved growth but decreased conception rates of primiparous beef females.
Selenium deficiency modulates necroptosis-mediated intestinal inflammation in broiler through the lncRNAWSF27/miRNA1696/GPX3 axis
Authors: Zhang Yiming , Wei Chunyu , Ding Jiayi , Chu Jiahong , Huang Bo , Shi Guangliang , Li Shu 
Published: September 2024

Abstract
Deficiency of selenium (Se), an important trace element, causes diarrhea and even death in broilers, thereby affecting the economic development of poultry production. Adding Se is one way to relieve this situation; however, it has not fundamentally resolved intestinal inflammation. Therefore, we sought a new strategy to alleviate intestinal inflammation by studying the specific mechanisms of Se deficiency. By replicating the Se-deficient broiler model and establishing a chicken small intestinal epithelial cell (CSIEC) model, we determined that Se deficiency caused intestinal oxidative stress and necroptotic intestinal inflammation in broilers by decreasing glutathione peroxidase (GPX) 3 expression. Simultaneously, the expression of long non-coding RNA (lncRNA)WSF27 decreased and that of miR-1696 increased in Se-deficient intestines. Recently discovered competing endogenous RNAs (ceRNAs) form novel regulatory networks, which were found that selenoproteins are involved in ceRNA regulation. However, the mechanism of action of the non-coding RNA/GPX3 axis in Se-deficient broiler intestinal inflammation remains unclear. This study aimed to explore the mechanism through which Se deficiency regulates intestinal inflammation in broilers through the lncRNAWSF27/miR-1696/GPX3 axis. Our previous studies showed that lncRNAWSF27, miR-1696, and GPX3 have ceRNA-regulatory relationships. To further determine the role of the lncRNAWSF27/miR-1696/GPX3 axis in Se-deficient broiler intestinal inflammation, CSIEC models with GPX3 knockdown/overexpression, lncRNAWSF27 knockdown, or miR-1696 knockdown/overexpression were established to simulate intestinal injury. GPX3 knockdown, as well as lncRNAWSF27 and miR-1696 overexpression, aggravated cell damage. On the contrary, it can alleviate this situation. Our results reveal that the mechanism of lncRNAWSF27/miR-1696/GPX3 regulated Se-deficient broiler intestinal inflammation. This conclusion enriches our understanding of the mechanism of intestinal injury caused by Se deficiency and contributes to the diagnosis of Se-deficient intestinal inflammation and relevant drug development.
A Simple Theory of Deep Trade Integration
Authors: Parenti Mathieu , Vannoorenberghe Gonzague 
Published: September 2024

Abstract
Which countries should aim for regulatory cooperation, and to what extent should they pursue it? We develop an imperfectly competitive trade model that accounts for differences in technology and regulatory preferences regarding local consumption externalities across countries. Each country sets unique product standards, and firms incur costs when tailoring products to different markets. Trade occurs when the benefits of comparative advantages outweigh the desire for asymmetric regulations. Our findings indicate that regulatory cooperation, defined as the cooperative setting of standards, is most advantageous for countries with moderate differences in regulatory preferences. Shallow integration, however, falls short of achieving the optimal planner’s solution. Countries with strong comparative advantages in distinct externality-generating goods can pursue deeper regulatory cooperation through mutual regulatory concessions. Additionally, when regulatory preferences are highly dispersed, international cooperation tends to form regulatory blocs.
Chinese companies in tax havens
Authors: Noked Noam , Wang Jingyi 
Published: September 2024

Abstract
Alibaba and Baidu are frequently referred to as the ‘Chinese Amazon’ and the ‘Chinese Google’. However, these companies and many other Chinese multinational enterprises (MNEs) take the position that they are not Chinese residents for tax purposes. This position provides these MNEs tax advantages at the corporate and shareholder levels. We analyse the tax residence positions of the largest 79 Chinese MNEs with tax-haven-incorporated parent companies that are traded on major US stock exchanges. Our analysis of disclosures in these companies’ annual reports reveals that all of these companies reported that they are not resident enterprises for Chinese tax purposes. We then explore the expected implications of the global minimum tax on these MNEs, which will be affected by the non-resident status of their ultimate parent entities. The global minimum tax may reduce, but not eliminate, the tax advantages of these MNEs’ non-resident status.
A heart so black: a case of alkaptonuric ochronosis of the aortic and mitral valves in a female patient with severe aortic valve stenosis and coronary artery disease
Authors: Kamougeros Alex , Shiakos George , Ioannou Stelios , Tzanavaros Ioannis , Al-Jazrawi Zeyad , Ioannou Beatrice 
Published: September 2024

Abstract
Alkaptonuric ochronosis, characterized by the deposition of homogentisic acid in connective tissues, is commonly linked with alkaptonuria, a rare genetic disorder resulting from homogentisate 1,2-dioxygenase deficiency. Despite its association with alkaptonuria, ochronosis can occur in individuals without a prior diagnosis. This case report discusses a 64-year-old female with severe aortic valve stenosis and coronary artery disease who was found to have ochronotic pigmentation in the aortic and mitral valves, as well as in the aortic root intima and papillary muscles. This case emphasizes the need to consider ochronosis in the differential diagnosis of valvular disease when alkaptonuria is suspected.
Stripping off the rice panicle: induced genetic variation awakens the sheathed spikelet for a better yield
Authors: Mohanty Jitendra K , Parida Swarup K 
Published: September 2024

This article comments on:
Ballichatla S, Gokulan CG, Barbadikar KM, Hake AA, Potupureddi G, Guha PK, Phule AS, Magar ND, Balija V, Awalellu K, Kokku P, Golla S, Sundaram RM, Padmakumari AP, Laha GS, Senguttuvel P, Lella Venkata SR, Patel HK, Sonti RV, Maganti SM. 2024. Impairment in a member of AP2/ERF and F-box family protein enhances complete panicle exsertion in rice. Journal of Experimental Botany 75, https://doi.org/10.1093/jxb/erae244.
Signatures of low-mass black hole–neutron star mergers
Authors: Matur Rahime , Hawke Ian , Andersson Nils 
Published: September 2024

ABSTRACT
The recent observation of the GW230529 event indicates that black hole–neutron star binaries can contain low-mass black holes. Since lower mass systems are more favourable for tidal disruption, such events are promising candidates for multimessenger observations. In this study, we employ five finite-temperature, composition-dependent matter equations of state and present results from ten 3D general relativistic hydrodynamic simulations for the mass ratios $q = 2.6$ and 5. Two of these simulations target the chirp mass and effective spin parameter of the GW230529 event, while the remaining eight contain slightly higher mass black holes, including both spinning ($a_{\mathrm{ BH}} = 0.7$) and non-spinning ($a_{\mathrm{ BH}} = 0$) models. We discuss the impact of the equation of state, spin, and mass ratio on black hole–neutron star mergers by examining both gravitational-wave and ejected matter properties. For the low-mass ratio model we do not see fast-moving ejecta for the softest equation of state model, but the stiffer model produces on the order of $10^{-6}\,\mathrm{ M}_\odot$ of fast-moving ejecta, expected to contribute to an electromagnetic counterpart. Notably, the high-mass ratio model produces nearly the same amount of total dynamical ejecta, but yields 52 times more fast-moving ejecta than the low-mass ratio system. In addition, we observe that the black-hole spin tends to decrease the amount of fast-moving ejecta while increasing significantly the total ejected mass. Finally, we note that the disc mass tends to increase as the neutron star compactness decreases.
VirID: Beyond Virus Discovery—An Integrated Platform for Comprehensive RNA Virus Characterization
Authors: Yang Ziyue , Shan Yongtao , Liu Xue , Chen Guowei , Pan Yuanfei , Gou Qinyu , Zou Jie , Chang Zilong , Zeng Qiang , Yang Chunhui , Kong Jianbin , Sun Yanni , Li Shaochuan , Zhang Xu , Wu Wei-chen , Li Chunmei , Peng Hong , Holmes Edward C , Guo Deyin , Shi Mang 
Published: September 2024

Abstract
RNA viruses exhibit vast phylogenetic diversity and can significantly impact public health and agriculture. However, current bioinformatics tools for viral discovery from metagenomic data frequently generate false positive virus results, overestimate viral diversity, and misclassify virus sequences. Additionally, current tools often fail to determine virus–host associations, which hampers investigation of the potential threat posed by a newly detected virus. To address these issues we developed VirID, a software tool specifically designed for the discovery and characterization of RNA viruses from metagenomic data. The basis of VirID is a comprehensive RNA-dependent RNA polymerase database to enhance a workflow that includes RNA virus discovery, phylogenetic analysis, and phylogeny-based virus characterization. Benchmark tests on a simulated data set demonstrated that VirID had high accuracy in profiling viruses and estimating viral richness. In evaluations with real-world samples, VirID was able to identify RNA viruses of all types, but also provided accurate estimations of viral genetic diversity and virus classification, as well as comprehensive insights into virus associations with humans, animals, and plants. VirID therefore offers a robust tool for virus discovery and serves as a valuable resource in basic virological studies, pathogen surveillance, and early warning systems for infectious disease outbreaks.
The use of biologic disease-modifying antirheumatic drugs does not increase surgical site infection or delayed wound healing after orthopaedic surgeries for rheumatoid arthritis
Authors: Kiso Yohei , Nishida Keiichiro , Harada Ryozo , Nasu Yoshihisa , Nakahara Ryuichi , Hotta Yoshifumi , Naniwa Shuichi , Ozaki Toshifumi 
Published: September 2024

ABSTRACT

Objective
To investigate the effect of the use of biologic disease-modifying antirheumatic drugs (bDMARDs) on surgical site infection (SSI) and delayed wound healing (DWH) in rheumatoid arthritis (RA) patients undergoing orthopaedic surgery.

Methods
We retrospectively reviewed the records of 965 elective orthopaedic procedures undertaken in RA patients. The incidences of SSI and DWH were compared between the bDMARDs user and nonuser groups. Subsequently, univariate and multivariate logistic regression analyses were performed to evaluate risk factors for SSI and DWH after propensity score matching. The incidence of postoperative flare-up was also examined.

Results
In 965 procedures, SSI and DWH were identified in 12 and 28 cases, respectively. SSI and DWH were identified in 3 and 17 of 414 procedures treated with bDMARDs, respectively. Flare-up occurred in 21 cases. Propensity score matching identified 315 cases in both groups, with no significant difference in incidence between the two groups. No risk factors for SSI were identified, whereas age, diabetes mellitus, foot and ankle surgery, and a history of musculoskeletal-related infection were identified as risk factors for DWH.

Conclusion
The use of bDMARDs was not associated with an increased incidence of SSI or DWH, with the incidence of flare-up being relatively low.
What citizens think about minority governments in majority coalition settings
Authors: Matthieß Theres , Stecker Christian 
Published: September 2024

Abstract
Political scientists have extensively studied the formation, management, or performance of minority governments. However, we still do not know much about citizens’ perspectives on this type of government. What do citizens think about minority governments, and under what conditions do they prefer them over majority governments? We hypothesize that cues from public opinion and instrumental calculations drive citizen attitudes toward minority governments. These hypotheses are tested through a two-round survey experiment employing a factorial design (N = 2,850) in Germany, a country traditionally characterized by a majority coalition setting yet increasingly experiencing debates on minority government formation amidst growing party fragmentation. We find that most German citizens prefer the formation of majority over minority governments. However, citizens favor the type of government they believe will yield desirable outcomes or benefit democracy. Consistent with our hypotheses, support for minority governments increases when citizens expect more policy influence and public opinion favors minority governments. The findings of this study have important implications for our understanding of different types of government and their perceived political legitimacy, especially in increasingly fragmented party systems.
Fine Motor Impairment and Its Impact on Social Outcomes in Survivors of Pediatric Acute Lymphoblastic Leukemia: St. Jude Lifetime Cohort Study
Authors: Iijima Mayuko , Hyun Geehong , Brinkman Tara M , Khan Raja B , Srivastava Deo Kumar , Robison Leslie L , Hudson Melissa M , Pui Ching-Hon , Krull Kevin R , Inaba Hiroto , Ness Kirsten K 
Published: September 2024

Abstract

aObjective
The impact of fine motor impairment among adult survivors of childhood acute lymphoblastic leukemia (ALL) on life after treatment is unknown.

Methods
This study evaluated prevalence and utilized multivariate logistic regression to identify risk factors for fine motor impairment among survivors of ALL, and associations with educational attainment and social independence. Latent class analysis defined social independence (independent, moderately independent, dependent), using employment, independent living, personal care assistance, routine need assistance, driver’s license status, and marital status inputs.

Results
Among 875 survivors who were ≥ 25 years old (age when most adults achieve independence) and ≥ 5 years from diagnosis (mean = 28.97 years), 33.6% had fine motor impairment, with scores at or below the 10th percentile of the scores of community controls (n = 460) on fine motor components of the physical performance test and the grooved peg-board test. Survivors exposed to cranial radiation had more fine motor impairment than those without (45.8% vs 20.2%). Male sex (exposed: odds ratio [OR] = 2.55, 95% confidence interval [CI] = 1.65–3.92; unexposed: OR = 3.02, 95% CI = 1.69–5.38) and lower scores on the Wechsler abbreviated scale of intelligence (exposed: OR = 0.46, 95% CI = 0.36–0.58; unexposed: OR = 0.43, 95% CI = 0.31–0.58) were risk factors for neuropathy. A 1-point-higher total neuropathy score was associated with 8% (95% CI = 1%–17%) increased odds of fine motor impairment. Fine motor impairment was associated with less than a college education (less than high school: OR = 2.23, 95% CI = 1.20–4.14; high school diploma/general equivalency diploma: OR = 2.66, 95% CI = 1.65–4.30; vocational education: OR = 2.07, 95% CI = 1.38–3.13) and less social independence (moderately independent: OR = 1.80, 95% CI = 1.15–2.83; dependent: OR = 2.65, 95% CI = 1.25–5.64).

Conclusion
Fine motor impairment in survivors of childhood ALL may interfere with optimal educational attainment and social independence.

Impact
Early identification of survivors at risk for fine motor impairment, with timely intervention, may improve long-term outcomes.