bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climatological and ultraviolet‐based habitability of possible exomoons in F‐star systems
Authors: Sato S. , Wang Zh. , Cuntz M. 
Published: March 2017

BackgroundThe identification of conditions suitable for life is considered a key element of modern‐day astronomy, astrophysics, and astrobiology. This research encompasses the environments of stars of different spectral types and evolutionary status. In this article, we focus on the possibility of habitable moons in selected F‐star systems.Materials and MethodsWe explore the astrobiological significance of F‐type stars of spectral type between F5 V and F9.5 V, which possess Jupiter‐type planets within or close to their climatological habitable zones. These planets, or at least a subset of those, may also possess rocky exomoons, which potentially offer habitable environments. Our work considers eight selected systems. The Jupiter‐type planets in these systems are in notably differing orbits with eccentricities between 0.08 (about Mars) and 0.72. We consider the stellar UV environments provided by the photospheric stellar radiation, which allows us to compute the UV habitable zones for the systems. Following previous studies, deoxyribonucleic acid (DNA) is taken as a proxy for carbon‐based macromolecules following the paradigm that extraterrestrial biology might be based on hydrocarbons.ResultsWe found that the damage inflicted on DNA is notably different for the range of systems studied, and also varies according to the orbit of the Jupiter‐type planet, especially for systems of high ellipticity, as expected. Furthermore, the UV levels in the CLI‐HZs of the F‐type stars are generally more severe than for the solar environment, except for regions beyond the outer limits of the general habitable zones. Particular emphasis was placed on locations akin to Earth‐equivalent (i.e., homeothermic) positions in the Solar System. The general conditions of habitability in F‐star systems are also affected by the rapidness of stellar evolution; nonetheless, based on previous research on the origin of life on Earth, a generally favorable assessment about the overall possibility of life around F‐type stars can be conveyed. For some systems studied here, excessive values of damage are attained if compared to today's Earth or during the Archean eon.ConclusionConsidering that the detection of exomoons around different types of stars will remain challenging in the foreseeable future, we view our work also as an example and template for investigating the combined requirements of climatological and UV‐based habitability for exosolar objects. Further studies for systems of stars with other spectral types and/or other evolutionary status will be considered as part of our future research.
SIG/MET: METRICS 2016: Workshop on Informetric and Scientometric Research
Authors: Paul‐Hus Adèle , Archambault Antoine 
Published: March 2017

EDITOR'S SUMMARYASIS&T SIG/MET held the METRICS 2016 workshop on October 14, 2016, in Copenhagen, Denmark. Topics covered during the workshop include informetrics, information retrieval, bibliometrics and scientometrics, especially as they apply to evaluation of individuals and scholarly work. Nine presentations were given at the full‐day workshop, as well as seven posters, three of which were open posters. The end of the event included presentation of the Best Student Paper award, a staple in the METRICS workshop, and the prize winners were invited to discuss their papers at the event. The SIG/MET Best Paper Award sponsored by Altmetric.com and Digital Science was awarded to Dangzhi Zhao and Lucinda Johnson for their case study To What Degree Are Uni‐citations Perfunctory? A Case Study.
Text and Data Mining Meets the Pharmaceutical Industry: Markus Bundschus Speaks
Authors: Hardin Steve 
Published: March 2017

EDITOR'S SUMMARYText and data mining have proven to greatly impact the world of biomedical research, especially for Roche Diagnostics in Penzberg, Germany. Taking information from such sources as patient literature, genomic cancer samples and PubMed articles, researchers at Roche Diagnostics are able to structure the data in a way that lends itself to creating personalized healthcare. Text mining used to build structured databases tends to yield the most relevant information for biomedical research, so Roche uses unstructured data to build a knowledge base automatically. This knowledge base, the disease marker association database, offers search capabilities for full text, abstracts or curated data. The database is made up of 50‐million scientific abstracts and leans on rule‐based engines as well as machine learning engines. By combining information from patient care, diagnoses and treatment, the healthcare industry can see a shift to digitization and more efficient care.
Tomato Tomahto: European Perspectives on Information Science
Authors: Warner Julian , Ibekwe‐SanJuan Fidelia , Peters Isabella , Lund Niels Windfeld , Buckland Michael 
Published: March 2017

EDITOR'S SUMMARYDuring a panel at the ASIS&T 2016 Annual Meeting in Copenhagen, attendees discussed European perspectives on the world of information science. The presentations and discussions took European contributions and views on information science and contrasted them with those of the United States. Niels Lund discussed the Nordic Library and Information Science (LIS) and the impact LIS had on education in Denmark starting in the 1980s. Julian Warner talked about the invention of the telegraph and differing opinions on intellectual property in databases between the United States and Europe. Fidelia Ibekwe‐SanJuan highlighted the development of information science in continental Europe and talked about coining terminology to better unify information standards across Europe. Michael Buckland discussed the history of documentation and neo‐documentalism and the European influences in that field. Isabella Peters closed the presentations with a sample of opinions on information science from the European Chapter of ASIS&T.
James M. Cretsos Leadership Award: Start Small and Keep Building: Experiences in and Advice for Serving ASIS&T
Authors: Worrall Adam 
Published: March 2017

EDITOR'S SUMMARYAdam Worrall, winner of the James M. Cretsos Leadership Award, shares his journey with ASIS&T and offers advice for new members looking to get more involved with the Association. He encourages new members to attend the ASIS&T Annual Meetings, and in particular the leadership workshop, to find new roles for which the Association may need volunteers. Adam also recommends networking with other people at any ASIS&T meeting to find colleagues or people with common interests that may have interesting insights on the Association or information science in general. He talks about finding a scholarly home and thinks ASIS&T is a great potential home for many people in the field of information science. Adam encourages new members to start small by volunteering where they can and keep building on that by finding new areas of interest.
Efficient and Selective Hydrosilylation of Secondary and Tertiary Amides Catalyzed by an Iridium(III) Metallacycle: Development and Mechanistic Investigation
Authors: Corre Yann , Trivelli Xavier , Capet Frédéric , Djukic Jean‐Pierre , Agbossou‐Niedercorn Francine , Michon Christophe 
Published: March 2017

AbstractReadily accessible cationic IrIII metallacycles catalyze efficiently the chemoselective hydrosilylation of tertiary and secondary amides to amines. The catalyst described herein operates at low loadings using inexpensive 1,1,3,3‐tetramethyldisiloxane and allows fast reactions with high yields, selectivities, and turnover numbers. A transient iminium intermediate has been observed for the first time by using mass spectrometry, and the activation of the catalyst and the silane reagent have been studied by using DFT calculations. These fundamental insights support the present and future improvements of IrIII metallacycles through proper ligand modifications and enable further broad applications of catalysts based on metallacycles.
Mass Transfer Characteristics in a Rotor‐Stator Reactor
Authors: Zhao Zemeng , Zhang Xiu , Li Guangjun , Chu Guangwen , Sun Baochang , Zou Haikui , Arowo Moses , Shao Lei 
Published: March 2017

AbstractMass transfer characteristics in a rotor‐stator reactor in terms of the overall volumetric mass‐transfer coefficient (Kxa) using the N2‐H2O‐O2 system were investigated. The effects of various operating parameters including rotation speed, liquid volumetric flow rate, and gas volumetric flow rate on Kxa were systematically examined, and a gas‐liquid mass transfer model was established to predict Kxa. Results reveal that Kxa increased with higher rotation speed, liquid volumetric flow rate, and gas volumetric flow rate. The results also confirm that the predicted values of Kxa were in agreement with the experimental values with deviation within 15 %. The results contribute to a better understanding of mass transfer characteristics in rotor‐stator reactors.
Self‐Supported CoP Nanorod Arrays Grafted on Stainless Steel as an Advanced Integrated Anode for Stable and Long‐Life Lithium‐Ion Batteries
Authors: Xu Xijun , Liu Jun , Hu Renzong , Liu Jiangwen , Ouyang Liuzhang , Zhu Min 
Published: March 2017

AbstractTo alleviate the capacity degradation of anode materials for Li‐ion batteries, caused by serious volume expansion and particle aggregation, intensive attention has been devoted to the rational design and fabrication of novel anode architectures. Herein, self‐supported CoP nanorod arrays have been facilely synthesized using hydrothemally deposited Co(CO3)0.5(OH)⋅0.11 H2O nanorod arrays as the precursor, through a gas‐phase phosphidation method. As the anode for Li‐ion batteries, such 3D interconnected CoP nanorod arrays show an initial discharge capacity of 1067 mAh g−1 and a high reversible charge capacity of 737 mAh g−1 at 0.4 Ag−1. After 400 cycles, their specific capacity can reach 510 mAh g−1; even after 900 cycles, they can still deliver a specific capacity of 390 mAh g−1. CoP//LiCoO2 full‐cells also exhibit a high reversible capacity of 400 mAh g−1 after 50 cycles. These unique 3D interconnected CoP nanorod arrays also show ultrastable cycling performance over 500 cycles when used as the anode in a Na‐ion battery.
Template‐Mediated Stabilization of a DNA G‐Quadruplex formed in the HIV‐1 Promoter and Comparative Binding Studies
Authors: Bonnat Laureen , Bar Laure , Génnaro Béatrice , Bonnet Hugues , Jarjayes Olivier , Thomas Fabrice , Dejeu Jérôme , Defrancq Eric , Lavergne Thomas 
Published: March 2017

AbstractG‐rich DNA oligonucleotides derived from the promoter region of the HIV‐1 long terminal repeat (LTR) were assembled onto an addressable cyclopeptide platform through sequential oxime ligation, a thiol‐iodoacetamide SN2 reaction, and copper‐catalyzed azide–alkyne cycloaddition reactions. The resulting conjugate was shown to fold into a highly stable antiparallel G4 architecture as demonstrated by UV, circular dichroism (CD), and NMR spectroscopic analysis. The binding affinities of six state‐of‐the‐art G4‐binding ligands toward the HIV‐G4 structure were compared to those obtained with a telomeric G4 structure and a hairpin structure. Surface plasmon resonance binding analysis provides new insights into the binding mode of broadly exploited G4 chemical probes and further suggests that potent and selective recognition of viral G4 structures of functional significance might be achieved.
Site‐Selective Modification of Proteins with Oxetanes
Authors: Boutureira Omar , Martínez‐Sáez Nuria , Brindle Kevin M. , Neves André A. , Corzana Francisco , Bernardes Gonçalo J. L. 
Published: March 2017

AbstractOxetanes are four‐membered ring oxygen heterocycles that are advantageously used in medicinal chemistry as modulators of physicochemical properties of small molecules. Herein, we present a simple method for the incorporation of oxetanes into proteins through chemoselective alkylation of cysteine. We demonstrate a broad substrate scope by reacting proteins used as apoptotic markers and in drug formulation, and a therapeutic antibody with a series of 3‐oxetane bromides, enabling the identification of novel handles (S‐to‐S/N rigid, non‐aromatic, and soluble linker) and reactivity modes (temporary cysteine protecting group), while maintaining their intrinsic activity. The possibility to conjugate oxetane motifs into full‐length proteins has potential to identify novel drug candidates as the next‐generation of peptide/protein therapeutics with improved physicochemical and biological properties.
A Case Study on the Influence of Substitutes on Interlayer Stacking of 2D Covalent Organic Frameworks
Authors: Fan Yu , Wen Qiang , Zhan Tian‐Guang , Qi Qiao‐Yan , Xu Jia‐Qiang , Zhao Xin 
Published: March 2017

AbstractInterlayer stacking of 2D covalent organic frameworks (COFs) plays a crucial role in determining not only the geometry of channels inside COFs but also the mobility of carrier transport between COF layers. However, though topological structures of 2D COFs monolayers can be precisely predicted through the structures of building blocks, factors affecting their interlayer stacking remain poorly understood. In this work, a truxene‐based building block on which six methyl groups are introduced was designed. The condensation of it with 1,4‐diaminobenzene or benzidine afforded 2D COFs with the methyl groups extending out‐of‐plane of the layers. A significant influence of the methyl groups on interlayer stacking of the COFs was revealed by the adoption of inclined packing of monolayers, which has never been experimentally observed before. This unprecedented stacking manner was confirmed by powder X‐ray diffraction analysis, pore‐size distribution analysis, and TEM investigation.
A Mild and Regiospecific Synthesis of Pyrazoleboranes
Authors: Brown Andrew W. , Comas‐Barceló Júlia , Harrity Joseph P. A. 
Published: March 2017

AbstractAlkynylboranes show unprecedented reactivity in their [4+2] cycloaddition of sydnones offering access to fully substituted pyrazoles within a few hours at room temperature. This method delivers synthetically valuable pyrazoleboranes with complete control of regioselectivity, and these intermediates can be further elaborated through functionalization of the C−B bond.
Large scale preparation of microbubbles by multi‐channel ceramic membranes: Hydrodynamics and mass transfer characteristics
Authors: Han Yang , Liu Yefei , Jiang Hong , Xing Weihong , Chen Rizhi 
Published: March 2017

AbstractMicrobubbles have potential applications in chemical engineering, water treatment, and medicine. By designing multi‐channel ceramic membrane distributors, large scale preparation of microbubbles is achieved in a co‐current bubble column. Oxygen and water are used as interacting gas‐liquid phases. Gas holdup, bubble size distribution, and mass transfer rate are influenced by the membrane pore size, superficial gas velocity, and cross flow velocity. The empirical correlations for gas holdup and volumetric mass transfer coefficient are formulated and good agreement with experimental data is obtained. The multi‐channel ceramic membranes can successfully produce a lot of microbubbles, resulting in larger values of gas holdup, volumetric mass transfer coefficient, and equilibrium dissolved oxygen concentrations as compared to the conventional gas sparger. These findings will aid the development of gas‐liquid reactors with high performances.
Dietary isoflavone intake and all‐cause mortality in breast cancer survivors: The Breast Cancer Family Registry
Authors: Zhang Fang Fang , Haslam Danielle E. , Terry Mary Beth , Knight Julia A. , Andrulis Irene L. , Daly Mary B. , Buys Saundra S. , John Esther M. 
Published: March 2017

BACKGROUNDSoy foods possess both antiestrogenic and estrogen‐like properties. It remains controversial whether women diagnosed with breast cancer should be advised to eat more or less soy foods, especially for those who receive hormone therapies as part of cancer treatment.METHODSThe association of dietary intake of isoflavone, the major phytoestrogen in soy, with all‐cause mortality was examined in 6235 women with breast cancer enrolled in the Breast Cancer Family Registry. Dietary intake was assessed using a Food Frequency Questionnaire developed for the Hawaii‐Los Angeles Multiethnic Cohort among 5178 women who reported prediagnosis diet and 1664 women who reported postdiagnosis diet. Cox proportional‐hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).RESULTSDuring a median follow‐up of 113 months (approximately 9.4 years), 1224 deaths were documented. A 21% decrease was observed in all‐cause mortality for women who had the highest versus lowest quartile of dietary isoflavone intake (≥1.5 vs < 0.3 mg daily: HR, 0.79; 95% confidence interval CI, 0.64‐0.97; Ptrend = .01). Lower mortality associated with higher intake was limited to women who had tumors that were negative for hormone receptors (HR, 0.49; 95% CI, 0.29‐0.83; Ptrend = .005) and those who did not receive hormone therapy for their breast cancer (HR, 0.68; 95% CI, 0.51‐0.91; Ptrend = .02). Interactions, however, did not reach statistical significance.CONCLUSIONSIn this large, ethnically diverse cohort of women with breast cancer living in North America, a higher dietary intake of isoflavone was associated with reduced all‐cause mortality. Cancer 2017;123:2070–2079. © 2017 American Cancer Society.
Human body modeling method to simulate the biodynamic characteristics of spine in vivo with different sitting postures
Authors: Dong Rui‐Chun , Guo Li‐Xin 
Published: March 2017

AbstractThe aim of this study is to model the computational model of seated whole human body including skeleton, muscle, viscera, ligament, intervertebral disc, and skin to predict effect of the factors (sitting postures, muscle and skin, buttocks, viscera, arms, gravity, and boundary conditions) on the biodynamic characteristics of spine. Two finite element models of seated whole body and a large number of finite element models of different ligamentous motion segments were developed and validated. Static, modal, and transient dynamic analyses were performed. The predicted vertical resonant frequency of seated body model was in the range of vertical natural frequency of 4 to 7 Hz. Muscle, buttocks, viscera, and the boundary conditions of buttocks have influence on the vertical resonant frequency of spine. Muscle played a very important role in biodynamic response of spine. Compared with the vertical posture, the posture of lean forward or backward led to an increase in stress on anterior or lateral posterior of lumbar intervertebral discs. This indicated that keeping correct posture could reduce the injury of vibration on lumbar intervertebral disc under whole‐body vibration. The driving posture not only reduced the load of spine but also increased the resonant frequency of spine.
Perspectives on HCV: Current Therapeutic Regimens and Drug–Drug Interactions
Authors: Chan Justin , Chung Raymond T. 
Published: March 2017

AbstractApproximately 170 million people harbor chronic infection with hepatitis C virus (HCV) worldwide, with 3–4 million in the United States. As recently as 2013, the few treatment options available were poorly tolerated and only moderately effective. That changed when the first interferon‐free direct‐acting antiviral (DAA) regimen was US Food and Drug Administration–approved in December 2013. There are now 10 approved DAAs, with several more deep in the pipeline to approval. There are now interferon‐free regimens available for every HCV genotype, and the application of DAA combination regimens has lifted response rates for historically difficult‐to‐treat patient groups to levels on par with more conventional treatment groups, including persons with HIV/HCV coinfection. This review will summarize the data behind currently recommended DAA regimens, review the data for treatment of HIV/HCV‐coinfected patients, and discuss important drug–drug interactions between HCV DAAs and HIV antiretrovirals.
User scheduling based on angles with block diagonalization in MU‐MIMO broadcast
Authors: Yuan Kun , Cao Yewen , Zhang Huanjing 
Published: March 2017

SummaryThis paper investigates user selection scheme in the multiuser multiple‐input multiple‐output (MU‐MIMO) broadcast (BC) scene with block diagonalization precoding. Block diagonalization is a suboptimal but practical linear precoding method, which can eliminate the multiuser interference by turning the MU‐MIMO BC channel into parallel MIMO channels. With this precoding method, we propose the best user from the user subset to maximize the total throughput in the MU‐MIMO BC system. The angles between subspaces used in this paper are induced fromn‐inner product, an extension from norm space to then‐dimensional space, which characterizes the orthogonality between subspaces. One of the algorithms achieves good performance by comparing the capacity greedily, the other one attains high capacity by reducing the cardinality of the user subset to improve the orthogonality between the user channels, which could be seen as a complexity reduction algorithm with respect to the former one. Indeed, they are all based on the angles between subspaces. Analysis shows that both of the proposed algorithms have lower complexity and better performance than the classical algorithms. The numerical results also confirm our analysis.
The cellularity yield of three different 22‐gauge endoscopic ultrasound fine needle aspiration needles
Authors: Othman Mohamed O. , Abdelfatah Mohamed M , Padilla Osvaldo , Hussinat Maha , Elhanafi Sherif , Eloliby Mohamed , Torabi Alireza , Hakim Nawar , Boman Darius A. 
Published: March 2017

BackgroundEndoscopic ultrasound (EUS) fine needle aspiration (FNA) is an integral part in the diagnosis of pancreatic, intestinal and extra‐intestinal masses or lesions. There is no clear data on the superiority of the core biopsy needle over standard 22‐gauge needles. The aim of this study is to prospectively compare the cellularity yield of three commonly used 22‐gauge FNA needles available in the US market. Methods: This is a prospective, randomized study comparing the cellularity yield of three commercially available EUS needles (two standard FNA needles and core biopsy needle). Two blinded pathologists evaluated the cytology specimens based on an already agreed upon cytology score. We included adult patients (18–80 years old) who presented to our endoscopy unit for FNA of pancreatic or extrapancreatic masses.Results109 patients (57 F, 52 M) were recruited to the study, 88 lesions were pancreatic lesions. 39 patients were recruited in the EZ Shot 2™ group, 36 in the Procore® group and 34 in the Expect™ group. The average cellularity score and the mean number of passes (SD) were not different between the three needles; P = 0.91 and P = 0.16, respectively. There was no difference between the three needles in obtaining an onsite diagnosis (P = 0.627) and no difference in reported adverse events between the three groups.ConclusionThe cellularity yields, the mean number of passes and reported adverse events were similar in the three compared 22‐gauge needles. Diagn. Cytopathol. 2017;45:426–432. © 2017 Wiley Periodicals, Inc.