The Vascular Impairment of Cognition Classification Consensus Study
Authors: Skrobot Olivia A. , O'Brien John , Black Sandra , Chen Christopher , DeCarli Charles , Erkinjuntti Timo , Ford Gary A. , Kalaria Rajesh N. , Pantoni Leonardo , Pasquier Florence , Roman Gustavo C. , Wallin Anders , Sachdev Perminder , Skoog Ingmar , Taragano F.E. , Kril J. , Cavalieri M. , Jellinger K.A. , Kovacs G.G. , Engelborghs S. , Lafosse C. , Bertolucci P.H. , Brucki S. , Caramelli P. , de Toledo Ferraz Alves T.C. , Bocti C. , Fulop T. , Hogan D.B. , Hsiung G.R. , Kirk A. , Leach L. , Robillard A. , Sahlas D.J. , Guo Q. , Tian J. , Hokkanen L. , Jokinen H. , Benisty S. , Deramecourt V. , Hauw J. , Lenoir H. , Tsatali M. , Tsolaki M. , Sundar U. , Coen R.F. , Korczyn A.D. , Altieri M. , Baldereschi M. , Caltagirone C. , Caravaglios G. , Di Carlo A. , DI Piero V. , Gainotti G. , Galluzzi S. , Logroscino G. , Mecocci P. , Moretti D.V. , Padovani A. , Fukui T. , Ihara M. , Mizuno T. , Kim S.Y. , Akinyemi R. , Baiyewu O. , Ogunniyi A. , Szczudlik A. , Bastos‐Leite A.J. , Firmino H. , Massano J. , Verdelho A. , Kruglov L.S. , Ikram M.K. , Kandiah N. , Arana E. , Barroso‐Ribal J. , Calatayud T. , Cruz‐Jentoft A.J. , López‐Pousa S. , Martinez‐Lage P. , Mataro M. , Börjesson‐Hanson A. , Englund E. , Laukka E.J. , Qiu C. , Viitanen M. , Biessels G.J. , de Leeuw F.‐E. , den Heijer T. , Exalto L.G. , Kappelle L.J. , Prins N.D. , Richard E. , Schmand B. , van den Berg E. , van der Flier W.M. , Bilgic B. , Allan L.M. , Archer J. , Attems J. , Bayer A. , Blackburn D. , Brayne C. , Bullock R. , Connelly P.J. , Farrant A. , Fish M. , Harkness K. , Ince P.G. , Langhorne P. , Mann J. , Matthews F.E. , Mayer P. , Pendlebury S.T. , Perneczky R. , Peters R. , Smithard D. , Stephan B.C. , Swartz J.E. , Todd S. , Werring D.J. , Wijayasiri S.N. , Wilcock G. , Zamboni G. , Au R. , Borson S. , Bozoki A. , Browndyke J.N. , Corrada M.M. , Crane P.K. , Diniz B.S. , Etcher L. , Fillit H. , Greenberg S.M. , Grinberg L.T. , Hurt S.W. , Lamar M. , Mielke M. , Ott B.R. , Perry G. , Powers W.J. , Ramos‐Estebanez C. , Reed B. , Roberts R.O. , Romero J.R. , Saykin A.J. , Seshadri S. , Silbert L. , Stern Y. , Zarow C. , Ben‐Shlomo Yoav , Passmore Anthony P. , Love Seth , Kehoe Patrick G. 
Published: December 2016

AbstractIntroductionNumerous diagnostic criteria have tried to tackle the variability in clinical manifestations and problematic diagnosis of vascular cognitive impairment (VCI) but none have been universally accepted. These criteria have not been readily comparable, impacting on clinical diagnosis rates and in turn prevalence estimates, research, and treatment.MethodsThe Vascular Impairment of Cognition Classification Consensus Study (VICCCS) involved participants (81% academic researchers) from 27 countries in an online Delphi consensus study. Participants reviewed previously proposed concepts to develop new guidelines.ResultsVICCCS had a mean of 122 (98–153) respondents across the study and a 67% threshold to represent consensus. VICCCS redefined VCI including classification of mild and major forms of VCI and subtypes. It proposes new standardized VCI‐associated terminology and future research priorities to address gaps in current knowledge.DiscussionVICCCS proposes a consensus‐based updated conceptualization of VCI intended to facilitate standardization in research.