bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and characterization of a chiral spirobifluorene cyclic hexamer
Authors: Kobayashi Seika , Nakazono Rina , Okada Rikito , Schramm Michael P , Amaya Toru 
Published: September 2024

Abstract
A new chiral macrocycle 1-[6], consisting of six chiral spirobifluorene units linked in a cyclic arrangement, was successfully synthesized via a homo-coupling of the corresponding acyclic trimer. Notably, this chiral cyclic hexamer exhibited flexibility in solution, and both low-temperature nuclear magnetic resonance (NMR) experiments and density functional theory (DFT) calculations suggest that its stable structure is not the hexagonal D6-symmetric structure but rather the figure-eight-shaped D2-symmetric structure. In this D2-symmetric structure, the opposing bifluorenyl units are π-stacked, and it is suggested that this π-stacked region undergoes rapid dissociation and reformation at room temperature. The HOMO is distributed over the π-stacked region, with a HOMO-LUMO gap of 4.02 eV. The macrocycle exhibited strong violet fluorescence. The absorption dissymmetry factor |gabs| was 7.4 × 10−3, which is larger compared to the series of chiral smaller macrocycles 1-[n] (n = 3 to 5). Additionally, the CPL efficiency, indicated by a BCPL value of 189 M−1 cm−1, is relatively high among chiral organic luminescent molecules.
Determination of adsorption capacity, regeneration ability, and aggregation tendency toward inorganic and organic pollutants of metal-doped carbon–silica composites in multicomponent systems
Authors: Medykowska Magdalena , Wiś niewska Małgorzata , Szewczuk-Karpisz Katarzyna 
Published: September 2024

Abstract
The main aim of the study was to develop a method for determining the adsorption capacity, regeneration ability, and aggregation tendency of metal-doped carbon–silica composites (iron-doped, C/Fe/SiO2, and manganese-doped, C/Mn/SiO2) against heavy metals and selected organic substances. The properties of these composites were compared with those of metal-free silica–carbon composite (C/SiO2). Inductively coupled plasma–optical emission spectrometry (ICP–OES) and high-pressure liquid chromatography were used to determine the adsorbed amounts and the desorption degree of organic/inorganic pollutants. Potentiometric titrations and electrophoretic mobility measurements were conducted to understand the mechanisms that were driving adsorption and particle aggregation. The size of the aggregates formed in the systems as well as the stability of the examined suspension were estimated by using ultraviolet-visible spectrophotometry. The performed experiments showed that the selected combination of methods is appropriate to determine the potential of metal-doped carbon–silica composites as adsorbents as well as the ease of their removal with adsorbed contaminants from aqueous solutions by sedimentation.
Lymphangiogenesis: novel strategies to promote cutaneous wound healing
Authors: Jian Yang , Li Yanqi , Zhang Yanji , Tang Mingyuan , Deng Mingfu , Liu Chenxiaoxiao , Cheng Maolin , Xiao Shune , Deng Chengliang , Wei Zairong 
Published: September 2024

Abstract
The cutaneous lymphatic system regulates tissue inflammation, fluid balance and immunological responses. Lymphangiogenesis or lymphatic dysfunction may lead to lymphedema, immune deficiency, chronic inflammation etc. Tissue regeneration and healing depend on angiogenesis and lymphangiogenesis during wound healing. Tissue oedema and chronic inflammation can slow wound healing due to impaired lymphangiogenesis or lymphatic dysfunction. For example, impaired lymphangiogenesis or lymphatic dysfunction has been detected in nonhealing wounds such as diabetic ulcers, venous ulcers and bedsores. This review summarizes the structure and function of the cutaneous lymphatic vessel system and lymphangiogenesis in wounds. Furthermore, we review wound lymphangiogenesis processes and remodelling, especially the influence of the inflammatory phase. Finally, we outline how to control lymphangiogenesis to promote wound healing, assess the possibility of targeting lymphangiogenesis as a novel treatment strategy for chronic wounds and provide an analysis of the possible problems that need to be addressed.
Left motor cortex contributes to auditory phonological discrimination
Authors: Perron Maxime , Ross Bernhard , Alain Claude 
Published: September 2024

Abstract
Evidence suggests that the articulatory motor system contributes to speech perception in a context-dependent manner. This study tested 2 hypotheses using magnetoencephalography: (i) the motor cortex is involved in phonological processing, and (ii) it aids in compensating for speech-in-noise challenges. A total of 32 young adults performed a phonological discrimination task under 3 noise conditions while their brain activity was recorded using magnetoencephalography. We observed simultaneous activation in the left ventral primary motor cortex and bilateral posterior–superior temporal gyrus when participants correctly identified pairs of syllables. This activation was significantly more pronounced for phonologically different than identical syllable pairs. Notably, phonological differences were resolved more quickly in the left ventral primary motor cortex than in the left posterior–superior temporal gyrus. Conversely, the noise level did not modulate the activity in frontal motor regions and the involvement of the left ventral primary motor cortex in phonological discrimination was comparable across all noise conditions. Our results show that the ventral primary motor cortex is crucial for phonological processing but not for compensation in challenging listening conditions. Simultaneous activation of left ventral primary motor cortex and bilateral posterior–superior temporal gyrus supports an interactive model of speech perception, where auditory and motor regions shape perception. The ventral primary motor cortex may be involved in a predictive coding mechanism that influences auditory-phonetic processing.
Brain markers of subtraction and multiplication skills in childhood: task-based functional connectivity and individualized structural similarity
Authors: Li Zheng , Fang Haifeng , Fan Weiguo , Wu Jiaoyu , Cui Jiaxin , Li Bao-ming , Wang Chunjie 
Published: September 2024

Abstract
Arithmetic, a high-order cognitive ability, show marked individual difference over development. Despite recent advancements in neuroimaging techniques have enabled the identification of brain markers for individual differences in high-order cognitive abilities, it remains largely unknown about the brain markers for arithmetic. This study used a data-driven connectome-based prediction model to identify brain markers of arithmetic skills from arithmetic-state functional connectivity and individualized structural similarity in 132 children aged 8 to 15 years. We found that both subtraction-state functional connectivity and individualized SS successfully predicted subtraction and multiplication skills but multiplication-state functional connectivity failed to predict either skill. Among the four successful prediction models, most predictive connections were located in frontal–parietal, default-mode, and secondary visual networks. Further computational lesion analyses revealed the essential structural role of frontal–parietal network in predicting subtraction and the essential functional roles of secondary visual, language, and ventral multimodal networks in predicting multiplication. Finally, a few shared nodes but largely nonoverlapping functional and structural connections were found to predict subtraction and multiplication skills. Altogether, our findings provide new insights into the brain markers of arithmetic skills in children and highlight the importance of studying different connectivity modalities and different arithmetic domains to advance our understanding of children’s arithmetic skills.
RP-HPLC Study of the Complexation of Acetamiprid, Imidacloprid and Carboxin Guest Molecules With Thiophosphorylated Calix [6] Arene in Dimethylformamide-Acetonitrile-Water Mobile Phase
Authors: Sharma Chandramauly R , Mishra Vijay , Agrawal Yadvendra 
Published: September 2024

Abstract
Reversed-phase high-performance liquid chromatography was used to study the host-guest complexation of thiophosphacalixarenes (TPC 1–3) with acetamiprid, imidacloprid and carboxin as guests. The Onyx Monolithic C 18 column (150 × 0.1 mm) and Phenomenex® were used with UV detection at 254 nm. The mobile phase consisted of dimethylformamide-acetonitrile-water. The association constant of the 1:1 guest-host complexes was determined from the relationship between the retention factor of the guest and concentration of the thiophosphacalix [6] arene host in the mobile phase. The stability constants are influenced by size, nature, position and quantity of substituents in the benzene ring of the calixarene skeleton. The detection limits for TPC 1, TPC 2 and TPC 3 are 0.95, 1.20 and 1.40 μg/mL, while the quantification limits are 2.85, 3.60 and 4.20 μg/mL for TPC 1, TPC 2 and TPC 3, respectively.
Atrioventricular nodal re-entrant tachycardia unmasking cardiac sarcoidosis: a clinical case report
Authors: Casteur Laura , Rosseel Thomas , Van Kerrebroeck Margaretha , Van Aelst Lucas , Ector Joris 
Published: September 2024

Abstract

Background
Sarcoidosis is a rare disease, and cardiac involvement is seen in the minority of patients. The clinical symptoms depend on the location of the noncaseating granulomas in the heart and vary from asymptomatic to atrioventricular (AV) conduction block, ventricular arrhythmia, heart failure, and sudden cardiac death. Clinically manifest cardiac sarcoidosis seldomly presents with supraventricular tachycardia.

Case summary
We present a case where a female patient presented with AV nodal re-entrant tachycardia as an uncommon initial presentation of cardiac sarcoidosis. Her resting electrocardiogram showed a complete left bundle branch block and first-degree AV conduction block. During hospitalization, there was continuous switching between sinus rhythm with first-degree AV block, 2:1 AV block, and AV nodal re-entrant tachycardia.

Discussion
It is important to be aware that cardiac sarcoidosis can rarely present with supraventricular tachycardia as initial symptom. Given the elevated risk of sudden cardiac death, early detection is crucial and all patients who require permanent pacing should be considered for implantable cardioverter-defibrillator implantation.
Deep-learning-driven optical coherence tomography analysis for cardiovascular outcome prediction in patients with acute coronary syndrome
Authors: Hamana Tomoyo , Nishimori Makoto , Shibata Satoki , Kawamori Hiroyuki , Toba Takayoshi , Hiromasa Takashi , Kakizaki Shunsuke , Sasaki Satoru , Fujii Hiroyuki , Osumi Yuto , Iwane Seigo , Yamamoto Tetsuya , Naniwa Shota , Sakamoto Yuki , Fukuishi Yuta , Matsuhama Koshi , Tsunamoto Hiroshi , Okamoto Hiroya , Higuchi Kotaro , Kitagawa Tatsuya , Shinohara Masakazu , Kuroda Koji , Iwasaki Masamichi , Kozuki Amane , Shite Junya , Takaya Tomofumi , Hirata Ken-ichi , Otake Hiromasa 
Published: September 2024

Abstract

Aims
Optical coherence tomography (OCT) can identify high-risk plaques indicative of worsening prognosis in patients with acute coronary syndrome (ACS). However, manual OCT analysis has several limitations. In this study, we aim to construct a deep-learning model capable of automatically predicting ACS prognosis from patient OCT images following percutaneous coronary intervention (PCI).

Methods and results
Post-PCI OCT images from 418 patients with ACS were input into a deep-learning model comprising a convolutional neural network (CNN) and transformer. The primary endpoint was target vessel failure (TVF). Model performances were evaluated using Harrell’s C-index and compared against conventional models based on human observation of quantitative (minimum lumen area, minimum stent area, average reference lumen area, stent expansion ratio, and lesion length) and qualitative (irregular protrusion, stent thrombus, malapposition, major stent edge dissection, and thin-cap fibroatheroma) factors. GradCAM activation maps were created after extracting attention layers by using the transformer architecture. A total of 60 patients experienced TVF during follow-up (median 961 days). The C-index for predicting TVF was 0.796 in the deep-learning model, which was significantly higher than that of the conventional model comprising only quantitative factors (C-index: 0.640) and comparable to that of the conventional model, including both quantitative and qualitative factors (C-index: 0.789). GradCAM heat maps revealed high activation corresponding to well-known high-risk OCT features.

Conclusion
The CNN and transformer-based deep-learning model enabled fully automatic prognostic prediction in patients with ACS, with a predictive ability comparable to a conventional survival model using manual human analysis.

Clinical Trial Registration
The study was registered in the University Hospital Medical Information Network Clinical Trial Registry (UMIN000049237).
Genome report: Genome sequence of tuliptree scale, Toumeyella liriodendri (Gmelin), an ornamental pest insect
Authors: Mongue Andrew J , Markee Amanda , Grebler Ethan , Liesenfelt Tracy , Powell Erin C 
Published: September 2024

Abstract
Scale insects are of interest both to basic researchers for their unique reproductive biology and to applied researchers for their pest status. In spite of this interest, there remain few genomic resources for this group of insects. To begin addressing this lack of data, we present the genome sequence of tuliptree scale, Toumeyella liriodendri (Gmelin) (Hemiptera: Coccomorpha: Coccidae). The genome assembly spans 536 Mb, with over 96% of sequence assembled into one of 17 chromosomal scaffolds. We characterize roughly 66% of this sequence as repetitive and annotate 16,508 protein-coding genes. Then we use the reference genome to explore the phylogeny of soft scales (Coccidae) and evolution of karyotype within the family. We find that T. liriodendri is an early-diverging soft scale, less closely related to most sequenced soft scales than a species of the family Aclerdidae is. This molecular result corroborates a previous, morphology-based phylogenetic placement of Aclerdidae within Coccidae. In terms of genome structure, T. liriodendri has nearly twice as many chromosomes as the only other soft scale assembled to the chromosome level, Ericerus pela (Chavannes). In comparing the two, we find that chromosome number evolution can largely be explained by simple fissions rather than more complex rearrangements. These genomic natural history observations lay a foundation for further exploration of this unique group of insects.
A new high-quality genome assembly and annotation for the threatened Florida Scrub-Jay (Aphelocoma coerulescens)
Authors: Romero Faye G , Beaudry Felix E G , Hovmand Warner Eyvind , Nguyen Tram N , Fitzpatrick John W , Chen Nancy 
Published: September 2024

Abstract
The Florida Scrub-Jay (Aphelocoma coerulescens), a federally Threatened, cooperatively breeding bird, is an emerging model system in evolutionary biology and ecology. Extensive individual-based monitoring and genetic sampling for decades has yielded a wealth of data, allowing for the detailed study of social behavior, demography, and population genetics of this natural population. Here, we report a linkage map and a chromosome-level genome assembly and annotation for a female Florida Scrub-Jay made with long-read sequencing technology, chromatin conformation data, and the linkage map. We constructed a linkage map comprising 4,468 SNPs that had 34 linkage groups and a total sex-averaged autosomal genetic map length of 2446.78 cM. The new genome assembly is 1.33 Gb in length, consisting of 33 complete or near-complete autosomes and the sex chromosomes (ZW). This highly contiguous assembly has an NG50 of 68 Mb and a Benchmarking Universal Single-Copy Orthologs completeness score of 97.1% with respect to the Aves database. The annotated gene set has a Benchmarking Universal Single-Copy Orthologs transcriptome completeness score of 95.5% and 17,964 identified protein-coding genes, 92.5% of which have associated functional annotations. This new, high-quality genome assembly and linkage map of the Florida Scrub-Jay provides valuable tools for future research into the evolutionary dynamics of small, natural populations of conservation concern.
The clinical efficacy of “water-jet” hemostasis in gastrointestinal endoscopic submucosal dissection
Authors: Chen Ran , Zhang Qingyong , Hong Shiya , Chen Fengying , Huang Xiaoqing , Bao Xiongfei , Ni Zhi , Zhang Rongchun 
Published: September 2024

Abstract

Objective
This study aims to evaluate the safety and efficacy of “water-jet” hemostasis during endoscopic submucosal dissection.

Methods
In this prospective single-arm clinical study, 10 patients aged 18–60 years with gastric or intestinal mucosal lesions who were admitted to Fujian Medical University Xiamen Humanity Hospital (Xiamen, P. R. China) between June 2022 and June 2023 and met the absolute indications for endoscopic treatment were finally analyzed. The primary outcomes of this study are the incidence rates of adverse events and R0 resection, and the secondary outcomes are length of hospital stay and short- and long-term outcomes.

Results
Successful hemostasis was achieved in all the included cases. In one case, the “water-jet” hemostasis failed to stop bleeding in one blood vessel, so the hemostatic forceps were used instead. No adverse events occurred in all cases. Pathologic results showed R0 resection in all samples.

Conclusion
The “water-jet” method is safe and feasible for hemostasis in endoscopic submucosal dissection.
Harnessing population diversity: in search of tools of the trade
Authors: Bzdok Danilo , Wolf Guy , Kopal Jakub 
Published: September 2024

Abstract
Big neuroscience datasets are not big small datasets when it comes to quantitative data analysis. Neuroscience has now witnessed the advent of many population cohort studies that deep-profile participants, yielding hundreds of measures, capturing dimensions of each individual’s position in the broader society. Indeed, there is a rebalancing from small, strictly selected, and thus homogenized cohorts toward always larger, more representative, and thus diverse cohorts. This shift in cohort composition is prompting the revision of incumbent modeling practices. Major sources of population stratification increasingly overshadow the subtle effects that neuroscientists are typically studying. In our opinion, as we sample individuals from always wider diversity backgrounds, we will require a new stack of quantitative tools to realize diversity-aware modeling. We here take inventory of candidate analytical frameworks. Better incorporating driving factors behind population structure will allow refining our understanding of how brain–behavior relationships depend on human subgroups.
Non-conventional arrays for self-potential surveys
Authors: Souza de Araújo Oziel , Butler Samuel , Picotti Stefano , Francese Roberto G , Mendonça Carlos Alberto , Fischanger Federico , Giorgi Massimo 
Published: September 2024

SUMMARY
The exponential growth of electrical resistivity tomography (ERT) methods for exploring the subsurface at large depths widened the applicability of the self-potential (SP) method, a passive geoelectrical technique suitable for a variety of purposes like mapping ore bodies or inferring fluid flow in the subsurface. Several new-generation resistivity meters have been designed to continuously log the electric potentials thus allowing for the identification of weak amplitude signals and resulting in deeper inversion models. In such approaches, long SP time-series are collected but are totally ignored as only marginal intervals are retained and analysed in the ERT procedure. The discarded SP records could be valuable although not collected using the traditional methodology, based on a reference electrode. We present an SP forward modelling feasibility study of different array techniques, based on numerical finite-element methods. The SP has been modelled in a variety of electrical settings to assess the imaging potentials of non-conventional (i.e. sparse gradient and full sparse gradient) arrays in comparison to traditional (i.e. fixed-base and the leapfrog) arrays. The analytic signal amplitude (ASA) algorithm was employed to compare numerical modelling results obtained from the different type of arrays, highlighting the great potentials of non-conventional arrays for the recognition of several sources of SP anomalies. The ASA maps, presenting a single peak centred over the targets, can significantly help in identifying the source anomalies for all the analysed array techniques. The cost-effectiveness along with the imaging capability of these non-conventional arrays constitute important benefits that could be exploited resulting in a systematic inclusion of SP analysis when collecting deep ERT data using distributed systems.
Logarithmic Sobolev Inequalities on Homogeneous Spaces
Authors: Gordina Maria , Luo Liangbing 
Published: September 2024

Abstract
We consider sub-Riemannian manifolds which are homogeneous spaces equipped with a sub-Riemannian structure induced by a transitive action by a Lie group. Then the corresponding sub-Laplacian is not an elliptic but a hypoelliptic operator. We study logarithmic Sobolev inequalities with respect to the hypoelliptic heat kernel measure on such spaces. We show that the logarithmic Sobolev constant can be chosen to depend only on the Lie group acting transitively on such a space but the constant is independent of the action of its isotropy group. This approach allows us to track the dependence of the logarithmic Sobolev constant on the geometry of the underlying space, in particular we show that the constant is independent of the dimension of the underlying spaces in several examples.
A Single Institution’s Surgical Care Model for Pediatric Burns With ≤10% Body Surface Area Involvement
Authors: Zuccaro Jennifer , Lee David , Kelly Charis , Chakera Hawwa , Turner Evan , Gus Eduardo , Fish Joel S 
Published: September 2024

Abstract
Small burn injuries are extremely prevalent in the pediatric population and continue to pose a challenge for clinicians. Despite their high incidence, a standardized algorithm for treating small burns does not currently exist, and care is often guided by clinical judgement and resource availability. The aim of this study was to explore the utility of a two-stage grafting technique, involving allograft and autograft, for treating small burns (≤10% total body surface area) in pediatric patients. A retrospective review of patients aged 0-18 years who had a small burn and underwent a two-stage grafting procedure between September 1, 2018 and September 1, 2022 was conducted. One hundred and seventy-five patients with 220 wounds met the inclusion criteria for this study. The mean time from presentation to allograft surgery was 11.4 days (SD 5.2) followed by autograft surgery approximately one week later. Most patients were discharged within 24 hours following allograft surgery (87.4%) and autograft surgery (81.1%). Mean autograft take was 97.7% (SD 11.8) with only four patients experiencing significant graft loss requiring subsequent re-grafting. These positive outcomes demonstrate that the two-stage technique can be successfully utilized for treating smaller pediatric burns. Moreover, these findings help to address the significant knowledge gap regarding the optimal approach to treating small burn wounds. Further research is warranted to learn more about aesthetic outcomes following two-stage grafting and determine how it compares to other techniques for treating small burns.