bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes of mental health pharmacist-managed electronic consults at a Veterans Affairs health care system
Authors: Herbert Christina , Winkler Holly , Moore Troy A. 
Published: May 2017

AbstractIntroduction:The demand for mental health services has increased as more veterans have been diagnosed with—and sought care for—one or more mental health conditions. Within the South Texas Veterans Health Care System (STVHCS), providers may submit electronic consults (e-consults) to mental health clinical pharmacy specialists for medication review and recommendations. These consults aim to manage veterans with uncomplicated mental health conditions in primary care, making specialty mental health providers more available for those who need such services. Pharmacists have improved outcomes and access to care for conditions such as diabetes and hypertension, but currently, there is limited evidence demonstrating the impact of pharmacists in mental health.Methods:This quality improvement project assessed the effectiveness of the e-consult service. Information was collected through a retrospective chart review of STVHCS veterans with the corresponding consult note placed in their chart from May 2014 through December 2015. Numbers of recommendations implemented and veterans maintained in primary care were analyzed as markers of effectiveness. Time and cost savings were secondarily explored.Results:A total of 361 consults were submitted for 353 unique patients. Of the 322 patients included in analyses, a total of 301 unique patients (93.5%) were maintained in primary care for at least 3 months. Of the 21 not maintained in primary care, 15 recommendations were implemented; of those maintained in primary care, 271 recommendations were implemented.Discussion:This service improves mental health care—and patient access—by promoting successful management and maintenance of less complicated patients in primary care.
A geostatistics‐informed hierarchical sensitivity analysis method for complex groundwater flow and transport modeling
Authors: Dai Heng , Chen Xingyuan , Ye Ming , Song Xuehang , Zachara John M. 
Published: May 2017

AbstractSensitivity analysis is an important tool for development and improvement of mathematical models, especially for complex systems with a high dimension of spatially correlated parameters. Variance‐based global sensitivity analysis has gained popularity because it can quantify the relative contribution of uncertainty from different sources. However, its computational cost increases dramatically with the complexity of the considered model and the dimension of model parameters. In this study, we developed a new sensitivity analysis method that integrates the concept of variance‐based method with a hierarchical uncertainty quantification framework. Different uncertain inputs are grouped and organized into a multilayer framework based on their characteristics and dependency relationships to reduce the dimensionality of the sensitivity analysis. A set of new sensitivity indices are defined for the grouped inputs using the variance decomposition method. Using this methodology, we identified the most important uncertainty source for a dynamic groundwater flow and solute transport model at the Department of Energy (DOE) Hanford site. The results indicate that boundary conditions and permeability field contribute the most uncertainty to the simulated head field and tracer plume, respectively. The relative contribution from each source varied spatially and temporally. By using a geostatistical approach to reduce the number of realizations needed for the sensitivity analysis, the computational cost of implementing the developed method was reduced to a practically manageable level. The developed sensitivity analysis method is generally applicable to a wide range of hydrologic and environmental problems that deal with high‐dimensional spatially distributed input variables.
Identification and characterization of multifunctional cationic and amphipathic peptides from soybean proteins
Authors: Taniguchi Masayuki , Saito Kengo , Nomoto Takafumi , Namae Toshiki , Ochiai Akihito , Saitoh Eiichi , Tanaka Takaaki 
Published: May 2017

AbstractIn this study, we identified and chemically synthesized three cationic and amphipathic peptides (Glycinin‐17, BCAS‐16, and BCBS‐11) from soybean proteins. These peptides had high isoelectric points, high positive net charges, and included multiple hydrophobic amino acids. Subsequently, we identified multiple functions of these peptides, including antimicrobial, lipopolysaccharide‐neutralizing, and angiogenic activities, and examined their cytotoxic activities against mammalian red blood cells. Glycinin‐17, BCAS‐16, and BCBS‐11 exhibited antimicrobial activity against Porphyromonas gingivalis and Candida albicans whereas Glycinin‐17 did not possess antimicrobial effects on Propionibacterium acnes and Streptococcus mutans. Membrane‐depolarization assays and flow cytometric analyses showed that the antimicrobial properties of Glycinin‐17, BCAS‐16, and BCBS‐11 against P. gingivalis, P. acnes, and S. mutans were dependent on membrane‐disrupting potential. In contrast, major antimicrobial activities of these peptides against C. albicans were dependent on interactions with targets other than cell membranes. Furthermore, chromogenic Limulus amebocyte lysate assays showed that 50% effective concentrations (EC50, 0.12–0.31 μM) of these three peptides neutralize LPS with similar potency (EC50: 0.11 μM) to that of polymyxin B. Moreover, tube‐formation assays in human umbilical vein endothelial cells showed similar angiogenic activities of the three peptides as that following treatment with LL‐37. Although BCAS‐16 exhibited hemolytic activity, the rate of hemolysis for Glycinin‐17 and BCBS‐11 in the presence of 500‐μM Glycinin‐17 and BCBS‐11 was less than 2%. These results demonstrate that cationic and amphipathic peptides from soybean proteins, particularly Glycinin‐17 and BCBS‐11, have potential as multifunctional ingredients for healthcare applications.
A prospective longitudinal study of postnatal dentoalveolar and palatal growth: The anatomical basis for CAD/CAM‐assisted production of cleft‐lip‐palate feeding plates
Authors: Bauer Franz X. , Güll Florian D. , Roth Maximilian , Ritschl Lucas M. , Rau Andrea , Gau Dominik , Gruber Maximilian , Eblenkamp Markus , Hilmer Bettina , Wolff Klaus‐Dietrich , Loeffelbein Denys J. 
Published: May 2017

This study describes the dentoalveolar and palatal growth during the first months of life. Knowledge concerning this development is essential to avoid unwanted events such as mucosal ulcerations or restriction of growth when cleft‐lip and palate (CLP) patients are treated. The results involve the generation of CAD/CAM CLP‐feeding plates. Intraoral impressions from 32 healthy newborns were taken monthly for 5 months, supplemented by measurements of body weight, length, and occipital‐frontal head circumference. The casts were digitalized, and two observers manually selected defined anatomical landmarks on virtual 3‐D models. The distances between these landmarks were evaluted. Statistical analysis included an inter‐rater agreement analysis and the determination of growth. In total, 213 casts were analyzed, with 65 models excluded because of inaccuracies in impression‐taking or cast production. Overall longitudinal growth was 20.3%, whereas transversal growth reached a maximum of 21.1%. Vertical growth was 32.4% at the tuberal level. On the basis of these results, a semiautomated series of feeding plates allowing for monthly expansion could be generated. The acquired data serve as a useful reference for other pediatric and orthofacial investigations and treatments. One such application is the automated, fully virtual manufacture of CLP‐feeding plates based on only one impression‐taking. Our data reveal when caution is needed to prevent ulceration. The series of plates generated can minimize the time‐consuming impression‐taking and the production of further plaster models. The method of measurement is suitable for documentary purposes. Clin. Anat. 30:846–854, 2017. © 2017 Wiley Periodicals, Inc.
Transient analysis of the steam‐water direct contact condensation in the packed column
Authors: Hu Yunfa , Wang Yiping , Huang Qunwu , Cui Yong 
Published: May 2017

AbstractThe transient heat transfer behaviour of direct contact condensation of steam in spray cooling water in a packed column was investigated experimentally and theoretically in this work for the first time. A new analysis method of the state equation was applied to analyze the molar quantity variation of steam in the course of the experiment. The results showed that increasing the cooling water flow rate properly could significantly accelerate the steam condensation rate and this was more obvious at the beginning of the operation. The higher the flow rate of the cooling water was, the shorter a time it took for the steam to be completely condensed. When the cooling water flow rate was 840 L/h, the steam was mainly condensed within 13 s, which indicated that it would rapidly handle steam by regulating cooling water flow rate. However, the effect of changing cooling water temperature on steam condensation rate is slight with the cooling water temperature inceasing from 23 °C to 42 °C. The volumetric heat transfer coefficient in this experiment is in the range of 1.47 kW · m−3 · K−1 to 10.93 kW · m−3 · K−1 with the cooling water flow rate inceasing from 120 L/h to 840 L/h, and the maximum uncertainty in the results is 2.2 %.
Salt scales on process equipment: Measurement of the induction time for calcium carbonate nucleation
Authors: Mazziotti di Celso Giuseppe , Prisciandaro Marina , Karatza Despina , Lancia Amadeo , Musmarra Dino 
Published: May 2017

AbstractCalcium carbonate and calcium sulphate scales can lead to an increase in running costs, can decline or stop the flow of fluids, and can cause early equipment fouling and failure in several industrial sectors, such as oil industries and desalted water production plants. A way to delay or hinder the formation of these salts is to use a proper additive, able to modify the nucleation kinetic increasing the induction times for salt nucleation. However, in order to properly understand the overall phenomenon it is worth defining the scenario of calcium sulphate and carbonate salts nucleation kinetics in the absence of any additive. The scope of the work is to measure, with a high resolution and in‐line laser technique previously devised, the induction times for calcium carbonate nucleation on a lab scale plant. The experiments have been carried out at temperatures of 25 °C and 35 °C, with a supersaturation ratio S varying in the interval 2–210, and show that as expected the measured induction times for calcium carbonate nucleation strongly decrease while increasing supersaturation for each fixed temperature, outlining a wide metastable region. The obtained values have been used to evaluate the interfacial tension between salt crystals and mother solution (109.3 mJ/m2 for T = 25 °C and γsl = 95.7 mJ/m2 for T = 35 °C) that are in good agreement with other available literature values.
Museum specimen data reveal emergence of a plant disease may be linked to increases in the insect vector population
Authors: Zeilinger Adam R. , Rapacciuolo Giovanni , Turek Daniel , Oboyski Peter T. , Almeida Rodrigo P. P. , Roderick George K. 
Published: May 2017

AbstractThe emergence rate of new plant diseases is increasing due to novel introductions, climate change, and changes in vector populations, posing risks to agricultural sustainability. Assessing and managing future disease risks depends on understanding the causes of contemporary and historical emergence events. Since the mid‐1990s, potato growers in the western United States, Mexico, and Central America have experienced severe yield loss from Zebra Chip disease and have responded by increasing insecticide use to suppress populations of the insect vector, the potato psyllid, Bactericera cockerelli (Hemiptera: Triozidae). Despite the severe nature of Zebra Chip outbreaks, the causes of emergence remain unknown. We tested the hypotheses that (1) B. cockerelli occupancy has increased over the last century in California and (2) such increases are related to climate change, specifically warmer winters. We compiled a data set of 87,000 museum specimen occurrence records across the order Hemiptera collected between 1900 and 2014. We then analyzed changes in B. cockerelli distribution using a hierarchical occupancy model using changes in background species lists to correct for collecting effort. We found evidence that B. cockerelli occupancy has increased over the last century. However, these changes appear to be unrelated to climate changes, at least at the scale of our analysis. To the extent that species occupancy is related to abundance, our analysis provides the first quantitative support for the hypothesis that B. cockerelli population abundance has increased, but further work is needed to link B. cockerelli population dynamics to Zebra Chip epidemics. Finally, we demonstrate how this historical macro‐ecological approach provides a general framework for comparative risk assessment of future pest and insect vector outbreaks.
Leisure-Time Physical Activity and Risk of Fracture: A Cohort Study of 66,940 Men and Women
Authors: Stattin Karl , Michaëlsson Karl , Larsson Susanna C , Wolk Alicja , Byberg Liisa 
Published: May 2017

ABSTRACT Physical activity has been associated with reduced risk of fracture, but it is not known how the intensity or frequency of physical activity influences this risk reduction. We aim to compare the risk of hip fracture and fracture of any locale between men and women with different levels of leisure-time walking/bicycling and exercise. A total of 37,238 women (born 1914–1948) from the Swedish Mammography Cohort and 45,906 men (born 1918–1952) from the Cohort of Swedish Men were followed for a maximum of 17 years. Exposure and covariate information was collected through a self-administered questionnaire in 1997. Incident fractures (5153 individuals with hip fracture and 15,043 with any type of fracture) and comorbidities were gathered from national and local patient registries. Hazard ratios (HRs) were calculated using Cox proportional hazards regression. Individuals who walked/bicycled less than 20 minutes per day had a lower rate of hip fracture (multivariable adjusted HR = 0.77; 95% confidence interval [CI] 0.70 to 0.85) and any fracture (HR = 0.87; 95% CI 0.82 to 0.92) compared with those who hardly ever walked/bicycled. These reduced rates were also evident in both sexes, in different age categories, for vertebral fractures and for non-hip, non-vertebral fractures. Those who reported exercise 1 hour per week had a lower rate of hip fracture (HR = 0.87; 95% CI 0.80 to 0.96) and any fracture (HR = 0.94; 95% CI 0.89 to 0.99) compared with those who exercised less than 1 hour per week. Only minor differences in HRs were observed in individuals with moderate compared with higher levels of walking/bicycling or exercise. Walking/bicycling and exercise showed almost equal reductions in rate of fracture when compared with those in a joint category with lowest activity. In conclusion, both moderate and high self-reported frequency of physical activity is associated with reduced future risk of fracture. © 2017 American Society for Bone and Mineral Research.
Octreotide Is Ineffective in Treating Tumor-Induced Osteomalacia: Results of a Short-Term Therapy
Authors: Ovejero Diana , El-Maouche Diala , Brillante Beth A , Khosravi Azar , Gafni Rachel I , Collins Michael T 
Published: May 2017

ABSTRACT

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome in which unregulated hypersecretion of fibroblast growth factor 23 (FGF23) by phosphaturic mesenchymal tumors (PMT) causes renal phosphate wasting, hypophosphatemia, and osteomalacia. The resulting mineral homeostasis abnormalities and skeletal manifestations can be reversed with surgical resection of the tumor. Unfortunately, PMTs are often difficult to locate, and medical treatment with oral phosphate and vitamin D analogues is either insufficient to manage the disease or not tolerated. Octreotide has been proposed as a potential treatment for TIO due to the presence of somatostatin receptors (SSTR) on PMTs; however, the role of somatostatin signaling in PMTs and the efficacy of treatment of TIOs with somatostatin analogues is not clear. In an effort to evaluate the efficacy of octreotide therapy in TIO, five subjects with TIO were treated with octreotide for 3 days. Blood intact FGF23, phosphate, and 1,25(OH)2D3, and tubular reabsorption of phosphate (TRP) were measured at frequent time points during treatment. Octreotide's effects were assessed by comparing group means of the biochemical parameters at each time-point to mean baseline values. There were no significant changes in blood phosphate, FGF23, 1,25(OH)2D3, or TRP during octreotide treatment, consistent with a lack of efficacy of octreotide in treating TIO. © 2017 American Society for Bone and Mineral Research.
Identification of Key Gene Modules of Neuropathic Pain by Co‐Expression Analysis
Authors: Zhang Yang , Wang Jinlin , Ji Li‐Juan , Li Lin , Wei Meng , Zhen Su , Wen Cheng‐Cai 
Published: May 2017

ABSTRACTNeuropathic pain (NP) is a substantial clinical problem causing great injury to people word‐widely. Although gene expression analyses had been performed previously, the mechanisms underlying the etiology and development of NP are still poorly understood. To understand the function genes involved in the etiology and development of NP, we built the co‐expression modules and performed function enrichment analysis for neuropathic pain. In the present study, from a public microarray data set (GSE69901) from NCBI, gene co‐expression modules were contributed with the help of WGCNA for 12 neuropathic pain samples and 13 control samples, respectively. And functional enrichment analyses were followed by DAVID database. Firstly, we established 21 co‐expression modules and 19 co‐expression modules out of 5,000 high‐express genes in NP and control samples, respectively. Then, it showed great difference in interaction relationships of total genes and hub‐genes between pairwise modules, which indicated the high confidence of gene co‐expression modules. Finally, functional enrichment analysis of the top five co‐expression modules in NP exhibited great differences and significant enrichment in transcription regulation of RNA polymerase II promoter and ubiquitin mediated proteolysis pathway. RNA polymerase II promoter and ubiquitin‐mediated proteolysis pathway played important role in etiology and development of NP. Anyhow, our findings provided the framework of gene co‐expression modules of NP and furthered the understanding of these modules from functional aspect. J. Cell. Biochem. 118: 4436–4443, 2017. © 2017 Wiley Periodicals, Inc.
Removal of toluene from industrial gas over 13X zeolite supported catalysts by adsorption‐plasma catalytic process
Authors: Yi Honghong , Yang Xi , Tang Xiaolong , Zhao Shunzheng , Wang Jiangen , Cui Xiaoxu , Feng Tiecheng , Ma Yueqiang 
Published: May 2017

AbstractBACKGROUNDTo find an appropriate catalyst in the adsorption plasma catalytic process, degradation of toluene over 13X zeolite supported catalysts were studied.RESULTS13X zeolite exhibited excellent toluene adsorption capacity but weak catalytic ability. After loading Cu, Co, Ce and Mg active compounds by the impregnation method, adsorption capacity was reduced and catalytic performance was significantly improved. Co/13X exhibited good adsorption capacity and excellent catalytic performance, which carbon balance was 81.6% with 74.4% of COx for toluene adsorption capacity of 0.51 mmol. The effect of cobalt loading and calcination temperature on Co/13X for toluene degradation were studied, and it was found that 5% and 500°C were the optimum loading value and calcination temperature. The characterization results of BET, FTIR, XRD, XPS and SEM were correlated with catalyst performance.CONCLUSIONSThe active compounds block the pores and reduce the specific surface area of 13X zeolite, but active sites of catalysts can decompose ozone to produce more atomic oxygen species. Co3+ could form π‐complexation bonding with toluene and Co3O4 is a P‐type semiconductor, which has large oxygen adsorption capacity and converts oxygen into O− and O2− easily. Co3O4 present in Co/13X is the active point for toluene degradation by adsorption and plasma catalytic activity. © 2017 Society of Chemical Industry
Calreticulin inhibits inflammation‐induced osteoclastogenesis and bone resorption
Authors: Fischer Charla R. , Mikami Maya , Minematsu Hiroshi , Nizami Saqib , Goo Lee Heon , Stamer Danielle , Patel Neel , Yu Soung Do , Back Jung‐ho , Song Lee , Drissi Hicham , Lee Francis Y. 
Published: May 2017

ABSTRACTOsteoclasts play key roles in bone remodeling and pathologic osteolytic disorders such as inflammation, infection, bone implant loosening, rheumatoid arthritis, metastatic bone cancers, and pathological fractures. Osteoclasts are formed by the fusion of monocytes in response to receptor activators of NF‐κB‐ligand (RANKL) and macrophage colony stimulating factor 1 (M‐CSF). Calreticulin (CRT), a commonly known intracellular protein as a calcium‐binding chaperone, has an unexpectedly robust anti‐osteoclastogenic effect when its recombinant form is applied to osteoclast precursors in vitro or at the site of bone inflammation externally in vivo. Externally applied Calreticulin was internalized inside the cells. It inhibited key pro‐osteoclastogenic transcription factors such as c‐Fos and nuclear factor of activated T cells, cytoplasmic 1 (NFATc1)‐in osteoclast precursor cells that were treated with RANKL in vitro. Recombinant human Calreticulin (rhCRT) inhibited lipopolysaccharide (LPS)‐induced inflammatory osteoclastogenesis in the mouse calvarial bone in vivo. Cathepsin K molecular imaging verified decreased Cathepsin K activity when rhCalreticulin was applied at the site of LPS application in vivo. Recombinant forms of intracellular proteins or their derivatives may act as novel extracellular therapeutic agents. We anticipate our findings to be a starting point in unraveling hidden extracellular functions of other intracellular proteins in different cell types of many organs for new therapeutic opportunities. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2658–2666, 2017.