bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maximizing the Catalytic Activity of Nanoparticles through Monolayer Assembly on Nitrogen‐Doped Graphene
Authors: Yu Chao , Guo Xuefeng , Shen Mengqi , Shen Bo , Muzzio Michelle , Yin Zhouyang , Li Qing , Xi Zheng , Li Junrui , Seto Christopher T. , Sun Shouheng 
Published: November 2017

AbstractWe report a facile method for assembly of a monolayer array of nitrogen‐doped graphene (NG) and nanoparticles (NPs) and the subsequent transfer of two layers onto a solid substrate (S). Using 3 nm NiPd NPs as an example, we demonstrate that NiPd‐NG‐Si (Si=silicon wafer) can function as a catalyst and show maximum NiPd catalysis for the hydrolysis of ammonia borane (H3NBH3, AB) with a turnover frequency (TOF) of 4896.8 h−1 and an activation energy (Ea) of 18.8 kJ mol−1. The NiPd‐NG‐S catalyst is also highly active for catalyzing the transfer hydrogenation from AB to nitro compounds, leading to the green synthesis of quinazolines in water. Our assembly method can be extended to other graphene and NP catalyst materials, providing a new 2D NP catalyst platform for catalyzing multiple reactions in one pot with maximum efficiency.
Palladium‐Catalyzed Intermolecular Acylation of Aryl Diazoesters with ortho‐Bromobenzaldehydes
Authors: Yu Yinghua , Lu Qianqian , Chen Gui , Li Chunsen , Huang Xueliang 
Published: November 2017

AbstractIn this work, we describe a palladium‐catalyzed intermolecular O acylation of α‐diazoesters with ortho‐bromobenzaldehydes. The C(sp2)−H bond activation of the aldehyde is enabled by migratory insertion of a palladium carbene intermediate. The diazoesters act as modular three‐atom units to build up key seven‐membered palladacycles, which are transformed into a variety of isocoumarin derivatives upon reductive elimination. Mechanistic experiments and DFT calculations provide insight into the reaction pathway.
Microwave absorbing and mechanical properties of alternating multilayer carbonyl iron powder‐poly(vinyl chloride) composites
Authors: Gao Yuan , Gao Xiaoyan , Li Jiang , Guo Shaoyun 
Published: November 2017

ABSTRACTPolymeric composites filled with magnetic absorbents have been used extensively as microwave absorbing materials. However, their high filler content obstructed the application. In order to optimize the filler content and further improve the microwave absorbing properties, alternating multilayer carbonyl iron powder (CIP)/poly(vinyl chloride) (PVC) composites were designed and prepared by stacking neat PVC and CIP filled PVC alternately. The microwave absorbing properties were theoretically calculated by the transmission line theory and experimentally measured by the arch method, respectively. The experimental results were consistent with the calculated ones, which demonstrated that the alternating multilayer structure design can significantly improve the microwave absorbing property without increasing the filler content. The consistent results also demonstrated that the reflection loss (RL) of the multilayer composites was strongly dependent on the layer number and layer arranging sequence. The minimum RL (RL‐min) and effective bandwidth were exponentially dependent on the layer number. And the dependencies of the RL‐min and effective bandwidth on layer number exhibited a “regularity reversal” phenomenon when different layers faced to the incident wave. The mechanical property test showed that the alternating multilayer composites possessed enhanced tensile strength and elongation at break as the layer number increased. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 45846.
Characterization of two groups of Spodoptera exigua Hübner (Lepidoptera: Noctuidae) C‐type lectins and insights into their role in defense against the densovirus JcDV
Authors: Gasmi Laila , Jakubowska Agata K. , Ferré Juan , Ogliastro Mylène , Herrero Salvador 
Published: November 2017

AbstractInsect innate immunity relies on numerous soluble and membrane‐bound receptors, named pattern recognition proteins (PRPs), which enable the insect to recognize pathogen‐associated molecular patterns. C‐type lectins are among the best‐studied PRPs and constitute the most diverse family of animal lectins. Here we have characterized two groups of Spodoptera exigua C‐type lectins that differ in their phylogeny, domain architecture, and expression pattern. One group includes C‐type lectins with similar characteristics to other lepidopteran lectins, and a second group includes bracoviral‐related lectins (bracovirus‐like lectins, Se‐BLLs) recently acquired by horizontal gene transfer. Subsequently, we have investigated the potential role of some selected lectins in the susceptibility to Junonia coenia densovirus (JcDV). For this purpose, three of the bracoviral‐related lectins were expressed, purified, and their effect on the densovirus infection to two different Spodoptera species was assessed. The results showed that Se‐BLL3 specifically reduce the mortality of Spodoptera frugiperda larvae caused by JcDV. In contrast, no such effect was observed with S. exigua larvae. In a previous work, we have also shown that Se‐BLL2 increased the tolerance of S. exigua larvae to baculovirus infection. Taken together, these results confirm the implication of two different C‐type lectins in antiviral response and reflect the biological relevance of the acquisition of bracoviral genes in Spodoptera spp.
Relationships of the symmetric and asymmetric components of ENSO to US extreme precipitation
Authors: Yu Lejiang , Heilman Warren E. , Zhong Shiyuan , Bian Xindi 
Published: November 2017

AbstractWe used 35‐year (1979–2013) hourly rainfall data from the North American Land Data Assimilation System (NLDAS‐2) to examine the relationships of the symmetric and asymmetric components of two types of El Niño‐Southern Oscillation (ENSO) (El Niño and El Niño Modoki) episodes with occurrences of extreme precipitation events across the United States. During the cold season, the symmetric impacts of El Niño and El Niño Modoki are more significant than during the warm season. The asymmetric components associated with El Niño during the two seasons are comparable, while the asymmetric components associated with El Niño Modoki during the warm season are more significant than those during the cold season. The connections between the symmetric and asymmetric components of the two types of ENSO and extreme precipitation occurrences are related to atmospheric moisture convergence patterns that tend to occur in response to the anomalous large‐scale atmospheric circulations during the ENSO episodes.
Novel antioxidant and anti‐inflammatory peptides from the Siamese crocodile (Crocodylus siamensis) hemoglobin hydrolysate
Authors: Lueangsakulthai Jiraporn , Phosri Santi , Theansungnoen Tinnakorn , Jangpromma Nisachon , Temsiripong Theeranan , Mckendrick John E. , Khunkitti Watcharee , Klaynongsruang Sompong 
Published: November 2017

AbstractNovel antioxidant and anti‐inflammatory peptides were isolated from hydrolysates of Siamese crocodile (Crocodylus siamensis) hemoglobin.C. siamensishemoglobin hydrolysates (CHHs) were obtained by pepsin digestion at different incubation times (2, 4, 6, and 8 H) at 37 °C and subjected to antioxidant and anti‐inflammatory activity assessment. CHH obtained by 2‐H hydrolysis (2H‐CHH) showed the highest anti‐inflammatory activity with respect to decreasing nitric oxide (NO) production, whereas the strongest antioxidant activity was found for 6‐H hydrolysis (6H‐CHH) against nitric oxide radicals. To evaluate the anti‐inflammatory and antioxidant activity of individual peptide components, 2H‐CHH and 6H‐CHH were purified by semipreparative HPLC. Peptide fraction P57 isolated from 6H‐CHH was found to exhibit the highest nitric oxide radical inhibition activity (32.0%). Moreover, purification of 2H‐CHH yielded peptide fraction P16, which displayed a high efficacy in decreasing NO production of macrophage RAW 264.7 cells (83.2%) and significantly reduced proinflammatory cytokines and inflammatory mediators interleukin‐6 (IL‐6), interleukin‐1 beta (IL‐1β), and prostaglandin‐E2 (PGE2) production to about 2.0, 0.3, and 1.9 ng/mL, respectively. Using LTQ orbitrap XL mass spectrometry, active peptide sequences were identified as antioxidant KIYFPHF (KF7), anti‐inflammatory SAFNPHEKQ (SQ9), and IIHNEKVQAHGKKVL (IL15). Additionally, CHHs simulated gastric and intestinalin vitrodigestion positively contributed to antioxidant and anti‐inflammatory activity. Taken collectively, the results of this work demonstrate that CHHs contain several peptides with anti‐inflammatory and antioxidant properties, which may prove valuable as treatment or supplement against diseases associated with inflammation and oxidative stress.
Sequential crops for food, energy, and economic development in rural areas: the case of Sicily
Authors: Selvaggi Roberta , Valenti Francesca , Pappalardo Gioacchino , Rossi Lorella , Bozzetto Stefano , Pecorino Biagio , Dale Bruce E. 
Published: November 2017

AbstractIn this paper, we apply the principles of Biogasdoneright® to agriculture in Sicily (Italy), or more generally to Mediterranean agriculture. We propose new potential crop rotation schemes using Sorghum spp. drip irrigated second harvest and Italian sainfoin (Hedysarum coronarium L.) between two cycles of durum wheat to produce biogas and perhaps biomethane subsequently under the Biogasdoneright system. The Biogasdoneright system is a new model for sustainable biogas production based on sequential cropping and integration with food production. In Sicily, as in other Mediterranean countries, sequential crops and some perennial crops such as Opuntia spp. might be cultivated in environmentally critical areas prone to erosion, desertification, and fires. Therefore, biogas produced according to the crop rotation schemes as illustrated in this paper avoids competition with food and feed crops, while offering to the Sicilian agricultural sector many agronomic, economic, environmental, and social benefits. © 2017 Society of Chemical Industry and John Wiley & Sons, Ltd
Development and validation of a liquid chromatography–tandem mass spectrometry analytical method for the therapeutic drug monitoring of eight novel anticancer drugs
Authors: Herbrink M. , de Vries N. , Rosing H. , Huitema A. D. R. , Nuijen B. , Schellens J. H. M. , Beijnen J. H. 
Published: November 2017

AbstractTo support therapeutic drug monitoring of patients with cancer, a fast and accurate method for simultaneous quantification of the registered anticancer drugs afatinib, axitinib, ceritinib, crizotinib, dabrafenib, enzalutamide, regorafenib and trametinib in human plasma using liquid chromatography tandem mass spectrometry was developed and validated. Human plasma samples were collected from treated patients and stored at −20°C. Analytes and internal standards (stable isotopically labeled analytes) were extracted with acetonitrile. An equal amount of 10 mm NH4CO3 was added to the supernatant to yield the final extract. A 2 μL aliquot of this extract was injected onto a C18‐column, gradient elution was applied and triple‐quadrupole mass spectrometry in positive‐ion mode was used for detection. All results were within the acceptance criteria of the latest US Food and Drug Administration guidance and European Medicines Agency guidelines on method validation, except for the carry‐over of ceritinib and crizotinib. These were corrected for by the injection order of samples. Additional stability tests were carried out for axitinib and dabrafenib in relation to their reported photostability. In conclusion, the described method to simultaneously quantify the eight selected anticancer drugs in human plasma was successfully validated and applied for therapeutic drug monitoring in cancer patients treated with these drugs.
Comprehensive analysis of nine monoamines and metabolites in small amounts of peripheral murine (C57Bl/6 J) tissues
Authors: Nagler Joachim , Schriever Sonja C. , De Angelis Meri , Pfluger Paul T. , Schramm Karl‐Werner 
Published: November 2017

AbstractMonoamines, acting as hormones and neurotransmitters, play a critical role in multiple physiological processes ranging from cognitive function and mood to sympathetic nervous system activity, fight‐or‐flight response and glucose homeostasis. In addition to brain and blood, monoamines are abundant in several tissues, and dysfunction in their synthesis or signaling is associated with various pathological conditions. It was our goal to develop a method to detect these compounds in peripheral murine tissues. In this study, we employed a high‐performance liquid chromatography method using electrochemical detection that allows not only detection of catecholamines but also a detailed analysis of nine monoamines and metabolites in murine tissues. Simple tissue extraction procedures were optimized for muscle (gastrocnemius, extensor digitorum longus and soleus), liver, pancreas and white adipose tissue in the range of weight 10–200 mg. The system allowed a limit of detection between 0.625 and 2.5 pg μL−1 for monoamine analytes and their metabolites, including dopamine, 3,4‐dihydroxyphenylacetic acid, 3‐methoxytyramine, homovanillic acid, norepinephrine, epinephrine, 3‐methoxy‐4‐hydroxyphenylglycol, serotonin and 5‐hydroxyindoleacetic acid. Typical concentrations for different monoamines and their metabolization products in these tissues are presented for C57Bl/6 J mice fed a high‐fat diet.
Engineered Biomolecular Recognition of RDX by Using a Thermostable Alcohol Dehydrogenase as a Protein Scaffold
Authors: Bulutoglu Beyza , Haghpanah Jennifer , Campbell Elliot , Banta Scott 
Published: November 2017

AbstractThere are many biotechnology applications that would benefit from simple, stable proteins with engineered biomolecular recognition. Here, we explored the hypothesis that a thermostable alcohol dehydrogenase (AdhD from Pyrococcus furiosus) could be engineered to bind a small molecule instead of a cofactor or molecules involved in the catalytic transition state. We chose the explosive molecule 1,3,5‐trinitro‐1,3,5‐triazine (royal demolition explosive, RDX) as a proof‐of‐concept. Its low solubility in water was exploited for immobilization for biopanning by using ribosome display. Docking simulations were used to identify two potential binding sites in AdhD, and a randomized library focused on tyrosine or serine mutations was used to determine that RDX was binding in the substrate binding pocket of the enzyme. A fully randomized binding pocket library was selected, and affinity maturation by error‐prone PCR led to the identification of a mutant (EP‐16) that gained the ability to bind RDX with an affinity of (73±11) μm. These results underscore the way in which thermostable enzymes can be useful scaffolds for expanding the biomolecular recognition toolbox.
Mechanistic Insights into Growth of Surface‐Mounted Metal‐Organic Framework Films Resolved by Infrared (Nano‐) Spectroscopy
Authors: Delen Guusje , Ristanović Zoran , Mandemaker Laurens D. B. , Weckhuysen Bert M. 
Published: November 2017

AbstractControl over assembly, orientation, and defect‐free growth of metal‐organic framework (MOF) films is crucial for their future applications. A layer‐by‐layer approach is considered a suitable method to synthesize highly oriented films of numerous MOF topologies, but the initial stages of the film growth remain poorly understood. Here we use a combination of infrared (IR) reflection absorption spectroscopy and atomic force microscopy (AFM)‐IR imaging to investigate the assembly and growth of a surface mounted MOF (SURMOF) film, specifically HKUST‐1. IR spectra of the films were measured with monolayer sensitivity and <10 nm spatial resolution. In contrast to the common knowledge of LbL SURMOF synthesis, we find evidence for the surface‐hindered growth and large presence of copper acetate precursor species in the produced MOF thin‐films. The growth proceeds via a solution‐mediated mechanism where the presence of weakly adsorbed copper acetate species leads to the formation of crystalline agglomerates with a size that largely exceeds theoretical growth limits. We report the spectroscopic characterization of physisorbed copper acetate surface species and find evidence for the large presence of unexchanged and mixed copper‐paddle‐wheels. Based on these insights, we were able to optimize and automatize synthesis methods and produce (100) oriented HKUST‐1 thin‐films with significantly shorter synthesis times, and additionally use copper nitrate as an effective synthesis precursor.
Cobalt Pincer Complexes for Catalytic Reduction of Carboxylic Acid Esters
Authors: Junge Kathrin , Wendt Bianca , Cingolani Andrea , Spannenberg Anke , Wei Zhihong , Jiao Haijun , Beller Matthias 
Published: November 2017

AbstractA selection of cobalt(I) and cobalt(II) pincer type complexes with different substitution patterns was tested in the catalytic reduction of carboxylic acid esters to alcohols. The cobalt pincer type complex 4 is suitable for the hydrogenation of aromatic as well as aliphatic and cyclic esters. Mechanistic investigation indicated a metal ligand cooperated reaction pathway.
Transcatheter or surgical aortic valve replacement in patients with advanced kidney disease: A propensity score–matched analysis
Authors: Doshi Rajkumar , Shah Jay , Patel Vaibhav , Jauhar Varun , Meraj Perwaiz 
Published: November 2017

BackgroundTranscatheter aortic valve replacement (TAVR) is an alternative for surgically inoperable patients with severe aortic stenosis. Advanced kidney disease may significantly affect outcomes in patients treated with TAVR and surgical aortic valve replacement (SAVR).HypothesisTAVR is associated with better in‐hospital outcomes compared with SAVR in patients with advanced kidney disease.MethodsWe identified our sample from the National Inpatient Sample between 2012 and 2014, using International Classification of Diseases, Ninth Revision, Clinical Modification codes. We included patients with chronic kidney disease stages IV and V and end‐stage renal disease as advanced kidney disease patients. We excluded patients with acute kidney injury on admission and patients on dialysis.ResultsAfter propensity matching, 2485 patients were included in each group. The primary outcome of in‐hospital mortality (12.9% vs 6.2%; P < 0.01) was higher with SAVR as compared with TAVR. Patients who underwent SAVR reported higher acute kidney injury (50.3% vs 33%; P < 0.01) and dialysis requirements (26.8% vs 20.1%; P < 0.01). Other secondary outcomes including blood transfusion, atrial fibrillation, iatrogenic cardiac complications, pericardial complications, perioperative stroke, perioperative infections, and postoperative shock were more common with SAVR. With SAVR, the length of hospitalization and hospitalization costs were significantly higher; however, permanent pacemaker placement was more common with TAVR compared with SAVR.ConclusionsIn patients with advanced kidney disease, SAVR was associated with higher mortality and higher periprocedural complications, as compared with TAVR. Thus, benefits of TAVR could be extended in patients with advanced kidney disease who cannot undergo surgery.
Factors affecting compliance with confirmatory colonoscopy after a positive fecal immunochemical test in a national colorectal screening program
Authors: Cheng Shao‐Yi , Li Ming‐Chieh , Chia Shu‐Li , Huang Kuo‐Chin , Chiu Tai‐Yuan , Chan Ding‐Cheng , Chiu Han‐Mo 
Published: November 2017

BACKGROUNDScreening with the fecal immunochemical test (FIT) is effective in reducing deaths from colorectal cancer (CRC). Since 2004, biennial FIT screening has been available to a target population in Taiwan as a national screening program. The objective of the current study was to identify the factors that influence willingness to undergo a confirmatory colonoscopy after a positive FIT, because related references in the published literature were scarce.METHODSA semistructured questionnaire was based on the Health Belief Model (HBM) and a literature review. A stratified, random sampling method was used to recruit participants who had a positive FIT from all cities/counties in Taiwan. Cross‐sectional, computer‐assisted telephone interviews were conducted in 2012, and the results were analyzed using a logistic regression model that took into account population demographics, core content of the HBM, and HBM‐modifying variables.RESULTSIn total, 2807 respondents were included in the analysis. The completion rate was 50%. Multivariate analyses revealed that higher perceived threat (adjusted odds ratio [aOR], 1.62; 95% confidence interval [CI], 1.31‐2.01), higher cues for action (aOR, 2.18; 95% CI, 1.68‐1.82), lower perceived barriers (aOR, 0.42; 95% CI, 0.34‐0.42) and higher health behavior scores (aOR, 1.30; 95% CI, 1.05‐1.60) were associated with a greater willingness to participate in confirmatory colonoscopy. Participants who were older (aOR, 0.74; 95% CI, 0.55‐0.98) or unmarried (aOR, 0.72; 95% CI, 0.56‐0.92) were less likely to participate in verification.CONCLUSIONSThe government could improve the screening rate by training case managers to assist in following patients until they complete colonoscopy, subsidizing sedated colonoscopies, and providing health education not only to the general public but also to physicians.Cancer2018;124:907‐15. ©2017 American Cancer Society.
Fuzzy ACID properties for self‐adaptive composite cloud services execution
Authors: Cardinale Yudith , El Haddad Joyce , Manouvrier Maude , Rukoz Marta 
Published: November 2017

SummaryThe ACID transaction model has played a cornerstone role in service composition to guarantee that composite services (CSs) have transactional support and consistent outcomes even in presence of failures. However, the classical ACID properties are too restrictive for independent and multi‐proprietors services running on distributed environments, such clouds. Transactional properties allow a relaxed atomicity and isolation, providing an “all‐or‐(almost)nothing” model. In previous works, we proposed a model to relax atomicity, called fuzzy atomicity, according user requirements (acceptable fuzzy atomicity). In this article, we extend that model and propose an approach to measure the fuzzy atomicity. Our model allows to self‐adapt the CS execution, taking into account the state of the CS execution and user preferences (ie, the acceptable fuzzy atomicity expressed in the user requirements). This fuzzy atomicity measure is applied in a self‐adaptive CS execution model based on the transactional properties (pivot, compensatable, and retriable) of its component services and on a checkpointing mechanism. It is suitable to cloud computing, which offers cloud services on demand and in which CS execution should preserve the self‐organizing and self‐adaptivity properties of such environment, specially in the presence of failures. We show how it is possible to relax the retriable property in CSs execution, based on our fuzzy atomicity model. Additionally, in this work, we present a comparative analysis of the most recent works in the context of ACID properties relaxation for CS.
Constructing virtual 5‐dimensional tori out of lower‐dimensional network cards
Authors: Andújar Francisco J. , Villar Juan A. , Sánchez José L. , Alfaro Francisco J. , Duato José , Fröning Holger 
Published: November 2017

SummaryIn the Top500 and Graph500 lists of the last years, some of the most powerful systems implement a torus topology to interconnect the millions of computing nodes they include. Some of these torus networks are of five or six dimensions, which implies an additional difficulty as the node degree increases. In previous works, we proposed and evaluated the nD Twin (nDT) torus topology to virtually increase the dimensions a torus is able to implement. We showed that this new topology reduces the distances between nodes, increasing, therefore, global network performance. In this work, we present how to build a 5DT torus network using a specific commercial 6‐port network card (EXTOLL card) to interconnect those nodes. We show, using the same number of cards, that the performance of the 5DT torus network we are able to implement using our proposal is higher than the performance of the 3D torus network for the same number of compute nodes.