bluuebunny/crossref_metadata_2025_split huggingface dataset:
Minimal clinically important worsening on the progressive supranuclear Palsy Rating Scale
Authors: Hewer Sarah , Varley Sue , Boxer Adam L. , Paul Eldho , Williams David R ,   on behalf of the AL‐108‐231 Investigators
Published: June 2016

ABSTRACTBackgroundDespite the widespread use of the Progressive Supranuclear Palsy Rating Scale (PSPRS), it is not known what change in this scale is meaningful for patients.MethodsWe analyzed data from a large clinical trial in PSP‐Richardson's syndrome (AL‐108‐231) to calculate minimal clinically important worsening. This was defined as the difference in mean change of PSPRS in subjects rated “a little worse” and those rated “unchanged” on the Clinicians' Global Impression of Change Scale. A multivariate analysis using logistic regression assessed the relationship between clinical worsening, PSPRS, depression, and activities of daily living.ResultsThe minimal clinically important worsening on the PSPRS was 5.7 points, corresponding to the mean decline over 6 months in the trial. Changes in activities of daily living and PSPRS were significantly associated with clinical worsening.ConclusionsClinically meaningful change is measurable on the PSPRS over 6 months. © 2016 International Parkinson and Movement Disorder Society
Similar α‐Synuclein staining in the colon mucosa in patients with Parkinson's disease and controls
Authors: Antunes Laurent , Frasquilho Sonia , Ostaszewski Marek , Weber Jos. , Longhino Laura , Antony Paul , Baumuratov Aidos , Buttini Manuel , Shannon Kathleen M. , Balling Rudi , Diederich Nico J. 
Published: June 2016

ABSTRACTBackgroundThe gut is proposed as a starting point of idiopathic IPD, but the presence of α‐synuclein in the IPD colon mucosa is debated.ObjectivesThe objective of this study was to evaluate if α‐synuclein in the colon mucosa can serve as a biomarker of IPD.MethodsImmunohistochemistry was used to locate and quantify in a blinded approach α‐synuclein in the mucosa from biopsies of the right and left colon in 19 IPD patients and 8 controls.ResultsTotal α‐synuclein was present in all but 1 IPD patients and in all controls; phosphorylated α‐synuclein was present in all subjects. There was no intensity difference depending on disease status. Staining of total α‐synuclein was stronger in the right colon (p = .04).ConclusionsConventional immunohistochemistry α‐synuclein staining in colon mucosal biopsies cannot serve as a biomarker of idiopathic PD. These findings do not contradict the assumption of disease starting in the colon, and a colon segment‐specific risk for disease initiation can still be hypothesized. © 2016 International Parkinson and Movement Disorder Society
Different effects of anthocyanins and phenolic acids from wild blueberry (Vaccinium angustifolium) on monocytes adhesion to endothelial cells in a TNF‐α stimulated proinflammatory environment
Authors: Del Bo' Cristian , Roursgaard Martin , Porrini Marisa , Loft Steffen , Møller Peter , Riso Patrizia 
Published: June 2016

ScopeMonocyte adhesion to the vascular endothelium is a crucial step in the early stages of atherogenesis. This study aims to investigate the capacity of an anthocyanin (ACN) and phenolic acid (PA) rich fraction (RF) of a wild blueberry, single ACNs (cyanidin, malvidin, delphinidin) and related metabolites (protocatechuic, syringic, and gallic acid) to counteract monocytes (THP‐1) adhesion to human umbilical vein endothelial cells (HUVECs) in a tumor necrosis factor α (TNF‐α) mediated proinflammatory environment.Methods and resultsHUVECs were incubated with different concentrations (from 0.01 to 10 μg/mL) of the compounds for 24 h. Labeled monocytic THP‐1 cells were added to HUVECs and their adhesion was induced by TNF‐α (100 ng/mL). ACN‐RF reduced THP‐1 adhesion to HUVECs with a maximum effect at 10 μg/mL (−33%). PA‐RF counteracted THP‐1 adhesion at 0.01, 0.1, and 1 μg/mL (−45, −48.7, and −27.6%, respectively), but not at maximum concentration. Supplementation with gallic acid reduced THP‐1 adhesion to HUVECs with a maximum effect at 1 μg/mL (−29.9%), while malvidin‐3‐glucoside and syringic acid increased the adhesion. No effect was observed for the other compounds.ConclusionThese results suggest that ACNs/PA‐RF may prevent atherogenesis while the effects of the single ACNs and metabolites are controversial and merit further exploration.
A diamino based resin modified silica composite for the selective recovery of tungsten from wastewater
Authors: Dinker Manish Kumar , Patil Nitin Vishwas , Kulkarni Prashant Shripad 
Published: June 2016

AbstractA new adsorbent was developed by synthesizing 1,8‐diaminonaphthalene formaldehyde resin (DANFR) and coating it over the surface of silica gels. The silica composite was then treated with HCl for the activation of binding sites (−NH3+Cl−) on its surface. The structure of DANFR and its coating over the silanols were thoroughly characterized. Further, the adsorbent was applied to remove tungsten (W) from printed circuit board recycling unit wastewater that contained various co‐metal ions such as Na+, K+, Ca2+, Mg2+, Pb2+, NH4+, Zn2+, Cu2+ and Mn2+. The selective removal was achieved due to the anion exchange mechanism of Cl− with W(VI) while other cations get repelled from the surface (−NH3+) of the DANFR‐silica composite. X‐ray photoelectron spectroscopy studies, Raman spectra and overlay chromatograms of ion chromatography demonstrated selective separation of WO42− species from the wastewater. A removal capacity of 55.32 mg g−1 for W(VI) was achieved from the wastewater within 45 min of reaction (pH ca 6.0). Simultaneous treatment with neat aqueous solution of W brings out 63.27 mg g−1 of W(VI) removal. Finally, recovery of WO42− ions and regeneration of the adsorbent were carried out by using alkaline solution which demonstrated successful desorption, as investigated by using ion chromatography. © 2016 Society of Chemical Industry
An empirical study on developer‐related factors characterizing fix‐inducing commits
Authors: Tufano Michele , Bavota Gabriele , Poshyvanyk Denys , Di Penta Massimiliano , Oliveto Rocco , De Lucia Andrea 
Published: June 2016

AbstractThis paper analyzes developer‐related factors that could influence the likelihood for a commit to induce a fix. Specifically, we focus on factors that could potentially hinder developers' ability to correctly understand the code components involved in the change to be committed as follows: (i) the coherence of the commit (i.e., how much it is focused on a specific topic); (ii) the experience level of the developer on the files involved in the commit; and (iii) the interfering changes performed by other developers on the files involved in past commits. The results of our study indicate that ‘fix‐inducing’ commits (i.e., commits that induced a fix) are significantly less coherent than ‘clean’ commits (i.e., commits that did not induce a fix). Surprisingly, ‘fix‐inducing’ commits are performed by more experienced developers; yet, those are the developers performing more complex changes in the system. Finally, ‘fix‐inducing’ commits have a higher number of past interfering changes as compared with ‘clean’ commits. Our empirical study sheds light on previously unexplored factors and presents significant results that can be used to improve approaches for defect prediction. Copyright © 2016 John Wiley & Sons, Ltd.
ErbB Receptor Tyrosine Kinase: A Molecular Switch Between Cardiac and Neuroectoderm Specification in Human Pluripotent Stem Cells
Authors: Ramachandra Chrishan J. A. , Mehta Ashish , Lua Chong Hui , Chitre Anuja , Ja K. P. Myu Mai , Shim Winston 
Published: June 2016

Abstract
Mechanisms determining intrinsic differentiation bias inherent to human pluripotent stem cells (hPSCs) toward cardiogenic fate remain elusive. We evaluated the interplay between ErbB4 and Epidemal growth factor receptor (EGFR or ErbB1) in determining cardiac differentiation in vitro as these receptor tyrosine kinases are key to heart and brain development in vivo. Our results demonstrate that during cardiac differentiation, cell fate biases exist in hPSCs due to cardiac/neuroectoderm divergence post cardiac mesoderm stage. Stage-specific up-regulation of EGFR in concert with persistent Wnt3a signaling post cardiac mesoderm favors commitment toward neural progenitor cells (NPCs). Inhibition of EGFR abrogates these effects with enhanced (&gt;twofold) cardiac differentiation efficiencies by increasing proliferation of Nkx2-5 expressing cardiac progenitors while reducing proliferation of Sox2 expressing NPCs. Forced overexpression of ErbB4 rescued cardiac commitment by augmenting Wnt11 signaling. Convergence between EGFR/ErbB4 and canonical/noncanonical Wnt signaling determines cardiogenic fate in hPSCs.
Hydro power flexibility for power systems with variable renewable energy sources: an IEA Task 25 collaboration
Authors: Huertas‐Hernando Daniel , Farahmand Hossein , Holttinen Hannele , Kiviluoma Juha , Rinne Erkka , Söder Lennart , Milligan Michael , Ibanez Eduardo , Martínez Sergio Martín , Gomez‐Lazaro Emilio , Estanqueiro Ana , Rodrigues Luis , Carr Luis , van Roon Serafin , Orths Antje Gesa , Eriksen Peter Børre , Forcione Alain , Menemenlis Nickie 
Published: June 2016

Hydro power is one of the most flexible sources of electricity production. Power systems with considerable amounts of flexible hydro power potentially offer easier integration of variable generation, e.g., wind and solar. However, there exist operational constraints to ensure mid‐/long‐term security of supply while keeping river flows and reservoirs levels within permitted limits. In order to properly assess the effective available hydro power flexibility and its value for storage, a detailed assessment of hydro power is essential. Due to the inherent uncertainty of the weather‐dependent hydrological cycle, regulation constraints on the hydro system, and uncertainty of internal load as well as variable generation (wind and solar), this assessment is complex. Hence, it requires proper modeling of all the underlying interactions between hydro power and the power system, with a large share of other variable renewables. A summary of existing experience of wind integration in hydro‐dominated power systems clearly points to strict simulation methodologies. Recommendations include requirements for techno‐economic models to correctly assess strategies for hydro power and pumped storage dispatch. These models are based not only on seasonal water inflow variations but also on variable generation, and all these are in time horizons from very short term up to multiple years, depending on the studied system. Another important recommendation is to include a geographically detailed description of hydro power systems, rivers’ flows, and reservoirs as well as grid topology and congestion. WIREs Energy Environ 2017, 6:e220. doi: 10.1002/wene.220This article is categorized under:

Wind Power > Science and Materials
Wind Power > Systems and Infrastructure
Gynaecological endoscopic surgical education and assessment. A diploma programme in gynaecological endoscopic surgery
Authors: Campo Rudi , Wattiez Arnaud , Tanos Vasilis , Di Spiezio Sardo Attilio , Grimbizis Grigoris , Wallwiener Diethelm , Brucker Sara , Puga Marco , Molinas Roger , O’Donovan Peter , Deprest Jan , Van Belle Yves , Lissens Ann , Herrmann Anja , Tahir Mahmood , Benedetto Chiara , Siebert Igno , Rabischong Benoit , De Wilde Rudy Leon 
Published: June 2016

AbstractIn recent years, training and education in endoscopic surgery has been critically reviewed. Clinicians, both surgeons as gynaecologist who perform endoscopic surgery without proper training of the specific psychomotor skills, are at higher risk to increased patient morbidity and mortality. Although the apprentice-tutor model has long been a successful approach for training of surgeons, recently, clinicians have recognised that endoscopic surgery requires an important training phase outside the operating theatre. The Gynaecological Endoscopic Surgical Education and Assessment programme (GESEA) recognises the necessity of this structured approach and implements two separated stages in its learning strategy. In the first stage, a skill certificate on theoretical knowledge and specific practical psychomotor skills is acquired through a high-stake exam; in the second stage, a clinical programme is completed to achieve surgical competence and receive the corresponding diploma. Three diplomas can be awarded: (a) the Bachelor in Endoscopy, (b) the Minimally Invasive Gynaecological Surgeon (MIGS) and (c) the Master level. The Master level is sub-divided into two separate diplomas: the Master in Laparoscopic Pelvic Surgery and the Master in Hysteroscopy. The complexity of modern surgery has increased the demands and challenges to surgical education and the quality control. This programme is based on the best available scientific evidence, and it counteracts the problem of the traditional surgical apprentice-tutor model. It is seen as a major step toward standardisation of endoscopic surgical training in general.
Yielding in Surfactant Suspension Pastes: Effect of Surfactant Type
Authors: Shukla Asheesh , Arnipally Sumanth , Dagaonkar Manoj , Joshi Yogesh M. 
Published: June 2016

AbstractIn this work, we study the rheological properties and the yielding behavior of cleaning pastes containing surfactant and abrasive particles, for three different types of surfactants, namely linear alkyl benzene sulfonate (LAS), alpha olefin sulfonate (AOS) and sodium lauryl ether sulfonate (SLES). All the pastes were observed to have soft solid‐like consistency with their elastic modulus significantly greater than the viscous modulus. With around 36 volume percent of particulate matter, the high stiffness of the pastes suggests that particles form a space spanning network. Interestingly, when subjected to oscillatory shear deformation with increasing strain amplitude, the elastic modulus undergoes a decrease in two steps thereby showing a two‐step yielding behavior. It is observed that the first yield stress does not show frequency dependence, and for LAS‐containing paste was the largest followed by AOS‐ and SLES‐containing pastes, respectively. The second yield stress, on the other hand, for all the three pastes is observed to increase with frequency. Careful assessment of the experimental data suggests that the first yielding event is due to rupture of the network which leads to formation of particulate aggregates. The second yielding event is attributed to breakage of aggregates. In both yielding phenomena, surfactants play an important role. Since, the phase behavior of surfactant in water determines the inter‐particle interaction and network density, the nature of surfactant has a pivotal influence on both the yielding phenomena in surfactant suspension pastes used for cleaning purposes.
Evaluation of external FRP-concrete bond in repaired concrete bridge girders and columns
Authors: Pallempati Hemachand , Beneberu Eyosias , Yazdani Nur 
Published: June 2016

Abstract
Fiber reinforced polymer (FRP) is increasingly used to strengthen damaged or structurally unsafe concrete bridges. The FRP wrapping on eight concrete bridges was evaluated with ASTM pull-off testing to assess the condition of the bonding. A majority of samples failed in the concrete substrate. However, large variations in failure modes and pull-off strengths were observed, possibly due to environmental degradation or improper application. A majority of samples failed in the ASTM Mode G in concrete. Average bond strength from columns samples was 20 % lower than that from girders, due to the difficulty of pull-off testing on round column surfaces.
Age‐stratified analysis of long‐term outcomes of transvaginal mesh repair for treatment of pelvic organ prolapse
Authors: Dong Shengnan , Zhong Yanbo , Chu Lei , Li Huaifang , Tong Xiaowen , Wang Jianjun 
Published: June 2016

AbstractObjectiveTo investigate long‐term outcomes after transvaginal mesh repair among patients with pelvic organ prolapse in different age groups.MethodsA retrospective cohort study was conducted among women who underwent transvaginal mesh repair with polypropylene mesh for pelvic organ prolapse of stage II or higher between January 2007 and November 2011 at a center in Shanghai, China. Patients were invited to attend a follow‐up appointment between July 2014 and May 2015. Surgical outcomes were compared among three age groups (≤ 59, 60–74, and ≥ 75 years), and quality‐of‐life questionnaires were evaluated. Multivariate logistic regression was used to identify risk factors associated with recurrent prolapse and mesh exposure.ResultsAmong 158 patients, 143 (90.5%) were objectively cured and 149 (94.3%) were subjectively cured at follow‐up. Surgical outcomes were similar across all age groups. Significant improvements were observed on the Pelvic Floor Distress Inventory across all applicable subscales in all age groups (P < 0.001 for all). Multivariate logistic regression showed that an active postoperative sex life significantly increased the risk of mesh exposure (odds ratio 11.89, 95% confidence interval 1.08–131.48; P = 0.043).ConclusionTransvaginal mesh repair was found to be a safe and effective technique for treating pelvic organ prolapse among women of all ages. An active postoperative sex life increased the odds of mesh exposure.
The value of ultrasonographic tubo‐ovarian abscess morphology in predicting whether patients will require surgical treatment
Authors: Kinay Tugba , Unlubilgin Eylem , Cirik Derya A. , Kayikcioglu Fulya , Akgul Mehmet A. , Dolen Ismail 
Published: June 2016

AbstractObjectiveTo determine if the ultrasonographic morphology of a tubo‐ovarian abscess (TOA) could be used to predict if a patient will require surgical treatment.MethodA retrospective cohort study reviewed medical records from patients diagnosed with TOA via ultrasonography between January 2009 and January 2014 at a tertiary referral center in Turkey. Patients with pelvic inflammatory disease and an inflammatory adnexal mass, identified during sonographic examination, were included in the study. Ultrasonographic morphology, demographic characteristics, and clinical and laboratory findings were compared between patients who required surgical treatment and those who did not.ResultsRecords were included from 164 patients; medical therapy was successful in 121 (73.8%) patients and 43 (26.2%) required surgical treatment. TOA morphology was identified, using ultrasonography, as unilocular cystic, complex multicystic mass, or pyosalpinx in 56 (34.1%), 73 (44.5%), and 35 (21.3%) patients, respectively. No correlation was present between ultrasonographic TOA morphology and patients requiring surgical treatment (all P > 0.05). Multivariate analyses demonstrated that an abscess larger than 6.5 cm in size (P = 0.027), fever at admission (P < 0.001), and parity greater than two (P = 0.026) were independent predictors of patients requiring surgical treatment for TOA.ConclusionAlthough increased TOA size, fever at admission, and parity were associated with increased odds of patients with TOA requiring surgical treatment, ultrasonographic TOA morphology was not.
Analysis of Migration Patterns of Disk Fragments and Contributing Factors in Extruded Lumbar Disk Herniation
Authors: Son Eun‐Seok , Kim Du Hwan , Jung Jae Won , Lee Donggyu 
Published: June 2016

AbstractBackgroundThe exact location of migrated extruded lumbar disk fragments is an important consideration in selecting a treatment plan. However, few descriptive reports of the migration pattern of extruded lumbar disk fragments are available.ObjectiveTo examine the distribution of disk fragments and possible contributing factors that affect their migration.DesignRetrospective descriptive study.SettingTertiary university outpatient and inpatient clinic.PatientsA total of 164 patients diagnosed with a symptomatic extruded lumbar disk from January 2011 to December 2012.MethodsLumbar spine magnetic resonance imaging scans of patients were retrospectively reviewed. The term “migration” was defined as the horizontal and vertical displacement of extruded material away from the opening in the annulus through which the material has extruded. Migration of the disk material was recorded in both the horizontal and vertical plane. In the horizontal plane, migration was recorded as central, paracentral, subarticular, or foraminal. In the vertical plane, migration was recorded as rostral or caudal.Main Outcome MeasurementsThe pattern of migration and the associated factors (age and the level of herniation) were analyzed.ResultsRostral and caudal migration was observed in 27% (95% confidence interval [CI], 21%‐35%) and 73% (95% CI, 66%‐79%) of the patients. Central, paracentral, subarticular, and foraminal migration was observed in 6% (95% CI, 3%‐11%), 67% (95% CI, 60%‐74%), 18% (95% CI, 13%‐25%), and 9% (95% CI, 5%‐14%) of the patients, respectively. A significant increase was observed in the incidence of rostral migration with increasing age (P = .048). A significant association was also noted between migration in the horizontal plane and increasing age (P = .01). A significant increase occurred in the incidence of foraminal extrusion with increasing age (P = .01). A significant association was found between migration in the vertical plane and horizontal plane; in patients with foraminal herniations, migration was always rostral (P < .001).ConclusionThe migration of extruded lumbar disk materials follows some general patterns. The results of this study may help spine interventionists and surgeons choose appropriate treatments for patients who have radiculopathy associated with lumbar disk extrusions.Level of EvidenceIV
Health Benefits of Zumba Fitness Training: A Systematic Review
Authors: Vendramin Barbara , Bergamin Marco , Gobbo Stefano , Cugusi Lucia , Duregon Federica , Bullo Valentina , Zaccaria Marco , Neunhaeuserer Daniel , Ermolao Andrea 
Published: June 2016

AbstractObjectiveAs an alternative to the traditional approach to physical exercise, new kinds of organized physical activity have been developed designed to engage large segments of the population. Among these, Zumba fitness is extremely popular, with a growing number of participants. This article aims to summarize and analyze the body of evidence on the effects of Zumba fitness interventions on physical function, fitness, and wellbeing.TypeSystematic review.Literature SurveyKeyword “Zumba” was identified as term for the literature research in MEDLINE, Scopus, Bandolier, PEDro, and Web of Science. Only studies published in peer‐reviewed journals written in English language were considered.MethodologyEleven manuscripts were classified as eligible with 586 total participants, ranging in age from 18 to 65 years. After a quality appraisal, we classified 4 studies as high‐quality investigations and 7 as low quality. Results were summarized in several domains: “anthropometric parameters and body composition,” “hormonal and metabolic profiles,” “aerobic and cardiovascular performance,” “muscular fitness parameters,” and “quality of life, pain score and physical activity questionnaire.”SynthesisResults from this systematic review indicated that Zumba fitness could be considered an effective type of physical activity able to improve aerobic capacity. Small but positive benefits were noted for reducing body weight and other body measurements. Furthermore, other effects, including psychological and social benefits on quality of life, were found after Zumba fitness interventions. Otherwise, limited evidence described positive effects on muscular strength and flexibility.ConclusionsZumba fitness could be considered an effective type of physical activity able to improve aerobic capacity. Limited evidence described positive effects on muscular strength and flexibility.Level of EvidenceII