bluuebunny/crossref_metadata_2025_split huggingface dataset:
A short telephone-call reminder improves bowel preparation, quality indicators and patient satisfaction with first colonoscopy
Authors: Gálvez Marisol , Zarate Angel , Espino Hector , Higuera-de la Tijera Fátima , Awad Richard , Camacho Santiago 
Published: November 2017

Abstract
Background and study aims Addition of a reminder program to conventional indications improves colonoscopy. The aim of this study was to evaluate the effectiveness of a short telephone call reminder (STCR) on a patient’s first colonoscopy.
Patients and methods One day before colonoscopy, we made a STCR of < 10 minutes to 141 randomly selected patients of 258 recruited. The STCRs informed patients about the procedure date, indications for taking laxatives, and dietetic requirements. Questions were clarified only when patients asked directly. We evaluated bowel preparation, quality indicators, and patient satisfaction. Data were expressed as mean ± SD and percentages. Statistical differences were evaluated by Student’s t and Chi squared tests; alpha = 0.05. All authors had access to the study data and reviewed and approved the final manuscript.
Results The STCR group had better bowel preparation which was demonstrated by higher completion frequency (97.16 % vs. 82.05 %), in less time (4.52 ± 3.06 vs. 5.38 ± 3.03 hours) intake of laxative, and higher Boston’s scale (7.66 ± 2.42 vs. 5.2 ± 1.65). Quality indicators of colonoscopy were better in patients that received a STCR [cecal intubation rate: 100.00 % vs. 87.18 %; polyp detection: 42.55 % vs. 9.4 %; and cecal arrival time (min): 12.09 ± 3.62 vs. 15.09 ± 5.02]. STCR patients were more satisfied (97.87 % vs. 55.56 %) and would repeat colonoscopy (21.99 % vs. 11.11 %).
Conclusions A simple additional step such as a STCR improves quality of bowel preparation, quality indicators, and satisfaction of patients undergoing their first colonoscopy. Clinical trial registry in Mexico City General Hospital: DI/16/107/3/108.
ΔNp63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis
Authors: Compagnone Mirco , Gatti Veronica , Presutti Dario , Ruberti Giovina , Fierro Claudia , Markert Elke Katrin , Vousden Karen H. , Zhou Huiqing , Mauriello Alessandro , Anemone Lucia , Bongiorno-Borbone Lucilla , Melino Gerry , Peschiaroli Angelo 
Published: November 2017

Significance
The p63 isoform ΔNp63, a master regulator of epithelial biology, is overexpressed/amplified in the majority of head and neck squamous cell carcinoma (HNSCC), the sixth most common cancer worldwide. Here, we provide a demonstration of a molecular and functional link between the activity of ΔNp63 and hyaluronic acid (HA), a major component of the extracellular matrix. We unveiled a ΔNp63-dependent transcriptional program involving genes regulating the metabolism (HAS3 and HYAL proteins) and the signaling (CD44) of HA. By directly controlling the expression of these HA-related genes, ΔNp63 contributes to the activation of proproliferative and prosurvival pathway in HNSCC. Accordingly, the p63/HA pathway is a negative prognostic factor of HNSCC patient survival.
Extreme learning machines for reverse engineering of gene regulatory networks from expression time series
Authors: Rubiolo M , Milone D H , Stegmayer G 
Published: November 2017

Abstract

Motivation
The reconstruction of gene regulatory networks (GRNs) from genes profiles has a growing interest in bioinformatics for understanding the complex regulatory mechanisms in cellular systems. GRNs explicitly represent the cause–effect of regulation among a group of genes and its reconstruction is today a challenging computational problem. Several methods were proposed, but most of them require different input sources to provide an acceptable prediction. Thus, it is a great challenge to reconstruct a GRN only from temporal gene expression data.

Results
Extreme Learning Machine (ELM) is a new supervised neural model that has gained interest in the last years because of its higher learning rate and better performance than existing supervised models in terms of predictive power. This work proposes a novel approach for GRNs reconstruction in which ELMs are used for modeling the relationships between gene expression time series. Artificial datasets generated with the well-known benchmark tool used in DREAM competitions were used. Real datasets were used for validation of this novel proposal with well-known GRNs underlying the time series. The impact of increasing the size of GRNs was analyzed in detail for the compared methods. The results obtained confirm the superiority of the ELM approach against very recent state-of-the-art methods in the same experimental conditions.

Availability and implementation
The web demo can be found at http://sinc.unl.edu.ar/web-demo/elm-grnnminer/. The source code is available at https://sourceforge.net/projects/sourcesinc/files/elm-grnnminer.

Supplementary information
Supplementary data are available at Bioinformatics online.
Focus on Effector-Triggered Susceptibility
Authors: Ma Wenbo , Wang Yuanchao , McDowell John 
Published: November 2017

Effector biology exhibits diversity at every level. Effector proteins play key roles in the molecular interplay between plants and plant-associated organisms, and effector biology remains one of the most active areas in the research field of molecular plant-microbe interactions. Using effectors as probes, much has been learned about pathogen virulence and host immunity, which has broad implications in developing disease-resistant crops that are essential for global food security. Thus, the MPMI Editorial Board is publishing this Focus Issue to showcase recent progress in this area. Additional content is available on the Focus on Effector-Triggered Susceptibility. A Phytophthora palmivora Extracellular Cystatin-Like Protease Inhibitor Targets Papain to Contribute to Virulence on Papaya Conserved RxLR Effectors From Oomycetes Hyaloperonospora arabidopsidis and Phytophthora sojae Suppress PAMP- and Effector-Triggered Immunity in Diverse Plants Molecular Basis of Citrus sunki Susceptibility and Poncirus trifoliata Resistance Upon Phytophthora parasitica Attack daTALbase: A Database for Genomic and Transcriptomic Data Related to TAL Effectors Phytophthora parasitica Effector PpRxLR2 Suppresses Nicotiana benthamiana Immunity The Agrobacterium F-Box Protein Effector VirF Destabilizes the Arabidopsis GLABROUS1 Enhancer/Binding Protein-Like Transcription Factor VFP4, a Transcriptional Activator of Defense Response Genes Accessories Make the Outfit: Accessory Chromosomes and Other Dispensable DNA Regions in Plant-Pathogenic Fungi
Measuring Nurse Educators’ Willingness to Adopt Inclusive Teaching Strategies
Authors: Levey Janet A. 
Published: November 2017

Abstract

AIM
The purpose of the study was to examine the characteristics and relationships of nurse educators’ teaching practices, knowledge, support, and willingness to adopt inclusive teaching strategies (WillAdITS).

BACKGROUND
Adopting more inclusive teaching strategies based on universal design for instruction is an innovative way for educators to reach today's diverse student body. However, the pedagogy has not diffused into nursing education.

METHOD
Descriptive statistics and hierarchical multiple regression were used for analyzing data from 311 nurse educators in prelicensure and RN to BSN programs.

FINDINGS
The model explained 44.8 percent of the variance in WillAdITS. The best indicators for this pedagogy were knowledge of universal design for instruction, social system support for inclusive teaching strategies, multiple instructional formats, and years of teaching.

CONCLUSION
Knowing factors influencing the adoption of inclusive teaching strategies can inform schools of nursing of areas needing further development in the preparation of novice to experienced educators to teach diverse learners.
Useful Intraoperative Technique for Percutaneous Stabilization of Bilateral Posterior Pelvic Ring Injuries
Authors: Eastman Jonathan G. , Kuehn Reilly J. , Chip Routt Milton L. 
Published: November 2017

Summary:
Treating patients with bilateral posterior pelvic ring injuries can be challenging. Placement of transiliac-transsacral style screws in available S1 or S2 osseous fixation pathways is becoming an increasingly common fixation method for these unstable injuries. We propose a percutaneous technique that sequences reduction and stabilization of 1 hemipelvis with at least 1 transiliac-transsacral screw and then uses the existing transiliac-transsacral screw and accompanying guide wires to assist in temporary stabilization and definitive fixation of the second hemipelvis.
Determinants of Length of Stay After Operative Treatment for Femur Fractures
Authors: Aizpuru Matthew , Staley Christopher , Reisman William , Gottschalk Michael B. , Schenker Mara L. 
Published: November 2017

Objectives:
To investigate the determinants of length of stay (LOS) for patients surgically treated for femur fractures.

Design:
Retrospective medical record review.

Setting:
Urban Level I Trauma Center.

Participants:
Three hundred twenty-one patients operatively treated for femur fractures between July 12, 2015 and July 12, 2016.

Intervention:
Intramedullary nailing, open reduction internal fixation, arthroplasty, or other (percutaneous screw or multiple hardware/technique) definitive fixation of femur fracture.

Main Outcome Measurements:
Hospital LOS.

Results:
Median LOS was 6.43 days (range 1–76 days). Patients were divided into 2 groups: LOS ≥6 days (n = 171) and LOS <6 days (n = 150). Univariate analysis revealed several preoperative, perioperative, and postoperative factors associated with extended LOS. Multivariate analysis demonstrated frailty [odds ratio (OR), 20.58], medical complications (OR, 20.09), an upper extremity injury (OR, 9.97), an ipsilateral lower extremity injury (OR, 6.34), time to definitive fixation (OR, 2.12), time to first physical therapy visit (OR, 1.77), and Injury Severity Score (OR, 1.14) were independent predictors of LOS.

Conclusions:
By understanding the determinants of LOS for patients with femur fracture, high-risk patients can be identified and interventions can be enacted. Earlier fixation and aggressive management of medical complications may decrease patients' LOS. Patients who meet frailty criteria under the Modified Frailty Index are at a twenty-fold increased risk of staying longer than 6 days after having a femur fracture. By identifying these patients on admission, strategies can be devised to reduce their LOS and economic burden.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Identifying Factors Predictive of Atlantoaxial Fusion Failure in Pediatric Patients
Authors: Brockmeyer Douglas L. , Sivakumar Walavan , Mazur Marcus D. , Sayama Christina M. , Goldstein Hannah E. , Lew Sean M. , Hankinson Todd C. , Anderson Richard C.E. , Jea Andrew , Aldana Philipp R. , Proctor Mark , Hedequist Daniel , Riva-Cambrin Jay K. 
Published: November 2017

Study Design.
Multicenter retrospective cohort study with multivariate analysis.

Objective.
To determine factors predictive of posterior atlantoaxial fusion failure in pediatric patients.

Summary of Background Data.
Fusion rates for pediatric posterior atlantoaxial arthrodesis have been reported to be high in single-center studies; however, factors predictive of surgical non-union have not been identified by a multicenter study.

Methods.
Clinical and surgical details for all patients who underwent posterior atlantoaxial fusion at seven pediatric spine centers from 1995 to 2014 were retrospectively recorded. The primary outcome was surgical failure, defined as either instrumentation failure or fusion failure seen on either plain x-ray or computed tomography scan. Multiple logistic regression analysis was undertaken to identify clinical and technical factors predictive of surgical failure.

Results.
One hundred thirty-one patients met the inclusion criteria and were included in the analysis. Successful fusion was seen in 117 (89%) of the patients. Of the 14 (11%) patients with failed fusion, the cause was instrumentation failure in 3 patients (2%) and graft failure in 11 (8%). Multivariate analysis identified Down syndrome as the single factor predictive of fusion failure (odds ratio 14.6, 95% confidence interval [3.7–64.0]).

Conclusion.
This retrospective analysis of a multicenter cohort demonstrates that although posterior pediatric atlantoaxial fusion success rates are generally high, Down syndrome is a risk factor that significantly predicts the possibility of surgical failure.

Level of Evidence: 3
Safety of IncobotulinumtoxinA in the Treatment of Facial Lines: Results From a Pooled Analysis of Randomized, Prospective, Controlled Clinical Studies
Authors: Coleman William P. , Sattler Gerhard , Weissenberger Petra , Hast Michael A. , Hanschmann Angelika 
Published: November 2017

BACKGROUND
The safety and efficacy of incobotulinumtoxinA in aesthetics has been established in multiple studies. Although individual studies have been reported, a combined assessment of incobotulinumtoxinA safety across studies is not available.

OBJECTIVE
To assess the frequency of adverse events (AEs) across prospective incobotulinumtoxinA studies in aesthetics.

MATERIALS AND METHODS
Safety data were assessed from 9 placebo-controlled or active-controlled single-dose studies on glabellar frown lines (GFL), crow's feet (CF), and upper facial lines (UFL). Analyses by treatment cycle included 4 repeat-dose studies on GFL and UFL.

RESULTS
One thousand three hundred seventy-seven subjects received incobotulinumtoxinA (GFL, n = 1,189; CF, n = 83; UFL, n = 105) in single-dose studies (placebo-controlled studies: incobotulinumtoxinA, n = 866; placebo, n = 395). Over 1,000 subjects received incobotulinumtoxinA in repeat-dose studies (GFL, n = 880; UFL, n = 290). In placebo-controlled single-dose studies, incidences of treatment-related AEs ranged from 5.4% (GFL) to 22.9% (UFL). The most frequent treatment-related AE in single-dose studies was headache (GFL, 4.8%; UFL, 11.4%). In repeat-dose studies, incidence of AEs was highest during cycle 1 (GFL, 8.9%; UFL, 17.2%) and decreased across treatment cycles. No serious treatment-related AEs were observed.

CONCLUSION
Results confirm the favorable safety and tolerability of incobotulinumtoxinA. The frequency of treatment-related AEs was low and may decrease with subsequent treatments.
Forehead Line Treatment With OnabotulinumtoxinA in Subjects With Forehead and Glabellar Facial Rhytids: A Phase 3 Study
Authors: Fagien Steven , Cohen Joel L. , Coleman William , Monheit Gary , Carruthers Jean , Street James , Larsen Kristin E. , Yushmanova Irina , Lei Xiaofang , Lee Elisabeth , Vitarella Domenico , Mao Cheri 
Published: November 2017

BACKGROUND
Effacement of horizontal forehead lines (FHL) with onabotulinumtoxinA has not been investigated in prospective Phase 3 studies.

OBJECTIVE
To evaluate safety and efficacy of onabotulinumtoxinA treatment of FHL together with glabellar lines (GL).

MATERIALS AND METHODS
A 12-month, Phase 3 study randomized subjects with moderate-to-severe FHL and GL to onabotulinumtoxinA 40 U or placebo, distributed between the frontalis (20 U) and glabellar complex (20 U). After Day 180, subjects could receive up to 2 additional open-label onabotulinumtoxinA treatments. Efficacy was assessed using the Facial Wrinkle Scale (FWS) and Facial Line Outcomes questionnaire.

RESULTS
The intent-to-treat (ITT) population included 391 subjects, and the modified ITT (mITT) population (subjects with psychological impact) included 254 subjects. After 30 days, onabotulinumtoxinA significantly improved the investigator- and subject-assessed appearance of FHL severity by at least 2 FWS grades in 61.4% of ITT subjects versus 0% of placebo subjects (p < .0001). In the mITT population, 94.8% of onabotulinumtoxinA subjects and 1.7% of placebo subjects achieved investigator- and subject-assessed FWS ratings of none/mild (p = .0003). Patient-reported outcomes were consistent with FWS ratings. OnabotulinumtoxinA was well tolerated.

CONCLUSION
OnabotulinumtoxinA 40 U distributed between the frontalis and glabellar complex was safe and effective for treatment of moderate-to-severe FHL.
Relationship between concomitant benzodiazepine-opioid use and adverse outcomes among US veterans
Authors: Gressler Laura E. , Martin Bradley C. , Hudson Teresa J. , Painter Jacob T. 
Published: November 2017

Abstract
Benzodiazepines and opioids are commonly used among veterans suffering from mental health disorders and pain conditions. The objective of this study is to determine whether concomitant benzodiazepine-opioid use increases the incidence of adverse outcomes above the baseline risk of nonacute opioid-only use. The dataset contained all veterans who filled at least 1 opioid prescription during the years 2008 to 2012. Nonacute opioid use was defined as having opioid prescriptions greater than or equal to 20 days within a 60-day period. Concomitant use was defined as having opioid and benzodiazepine prescriptions that overlapped for at least 7 days. Nonacute opioid-only users were matched to concomitant opioid-benzodiazepine users based on propensity scores. A 365-day observation period was used to identify adverse outcomes. The primary outcome examines the existence of one or more of the following outcomes: opioid-related accidents and overdoses, alcohol- and nonopioid drug-related accidents and overdoses, self-inflicted injuries, violence-related injuries, wounds/injuries overall, and death. A logistic propensity score adjusted regression controlling for propensity toward concomitant use was used to determine the association of concomitant use with adverse outcomes. The final matched sample consisted of 396,141 nonacute opioid-only using veterans and 48,971 concomitant benzodiazepine-opioid users. Receiving opioids and benzodiazepines concomitantly increased the risk of experiencing an adverse outcome with an odds ratio of 1.359 (95% confidence interval: 1.320-1.400; P < 0.0001). Among veterans receiving opioids, concomitant benzodiazepine use is associated with an increased risk of adverse outcomes when compared to the baseline risk of opioid-only using veterans.
Role of Preemptive Gabapentin on Postoperative Analgesia After Infraumbilical Surgeries Under Subarachnoid Block—A Randomized, Placebo-Controlled, Double-Blind Study
Authors: Tomar Gaurav S. , Singh Farhat , Cherian Grace 
Published: November 2017

Background:
Preemptive use of gabapentin might accelerate recovery by reducing acute post-inguinal herniorrhaphy pain and opioid requirement being an analgesic.

Study Question:
Assessing efficacy of three different doses of oral gabapentin premedication for postoperative pain management after inguinal herniorrhaphy under spinal anesthesia.

Study Design:
This prospective, randomized, placebo controlled study was performed on 120 male patients (ASA I/II) undergoing inguinal herniorrhaphy under subarachnoid block. Patients were divided into 4 groups of 30 patients each to receive placebo (group A) or gabapentin 400 mg (B) or 800 mg (C) or 1200 mg (D), administered orally 2 hours before surgery. Assessment of postoperative pain was made on the basis of the visual analog score (VAS), where 0 cm “no pain” and 10 cm “worst pain imaginable.” Patients received IV fentanyl 0.5 μg/kg bolus when VAS >3.

Measures and Outcomes:
VAS score at regular intervals, the first analgesic requirement and total opioid consumption within 24 hours after surgery along with side/adverse effect (s) of study drug in perioperative period.

Results:
The VAS of the study groups B, C, D were significantly lower than placebo group (A) at 0, 1, 2, 4, 8, 12, 16, 20, and 24-hour intervals after surgery (P < 0.05). The first analgesic need and total opioid consumption within 24 hours after surgery of study groups were significantly lower than placebo group (P < 0.005) while within study groups difference was not significant. Dizziness and somnolence were seen maximally in group D patients (P = 0.01). However, pruritus, nausea and vomiting though maximally reported among group (A) patients but statistically non-significant.

Conclusion:
Preemptive gabapentin is opioid sparing to control postoperative pain with anxiolysis and sedation. We found the optimal dose to be 400 mg for gabapentin. However, increasing dose from 400 to 1200 mg does not increase its efficacy as analgesic but with higher adverse effects.
Early Reduction of Pediatric Traumatic Posterior Hip Dislocation Is Much More Important Than the Treatment Procedure
Authors: Yuksel Serdar , Albay Cem 
Published: November 2017

Abstract
Traumatic hip dislocations are very rare in the pediatric population, and they are real emergent cases that can occur with minimal trauma. If they are not diagnosed immediately and reduction is not performed as soon as possible, they may cause problems such as avascular necrosis and degenerative arthritis. Performing reduction within the first 6 hours is of vital importance.
We aim to present the functional outcomes and radiographic results of 2 pediatric traumatic hip dislocation cases with 36 months of follow-up who were treated with abduction orthosis after the reduction. We want to emphasize the importance of reduction time in the outcome of posterior traumatic hip dislocations followed with abduction orthesis even if there is a trend and suggestion to treat these patients with spica cast with the review of the recent literature.
Association of Insurance With Use of Emergency Medical Services Among Children
Authors: Dayal Parul , Ruttan Timothy K. , Kissee Jamie L. , Sigal Ilana S. , Marcin James P. 
Published: November 2017

Objective
The use of emergency medical services (EMS) can be lifesaving for critically ill children and should be defined by the child's clinical need. Our objective was to determine whether nonclinical demographic factors and insurance status are associated with EMS use among children presenting to the emergency department (ED).

Methods
In this cross-sectional study using the National Hospital Ambulatory Medical Care Survey, we included children presenting to EDs from 2009 to 2014. We evaluated the association between EMS use and patients' insurance status using multivariable logistic regressions, adjusting for demographic, socioeconomic, and clinical factors such as illness severity as measured by a modified and recalibrated version of the Revised Pediatric Emergency Assessment Tool (mRePEAT) and the presence of comorbidities or chronic conditions. A propensity score analysis was performed to validate our findings.

Results
Of the estimated 191,299,454 children presenting to EDs, 11,178,576 (5.8%) arrived by EMS and 171,145,895 (89.5%) arrived by other means. Children arriving by EMS were more ill [mRePEAT score, 1.13; 95% confidence interval (CI), 1.12–1.14 vs mRePEAT score, 1.01; 95% CI: 1.01–1.02] and more likely to have a comorbidity or chronic condition (OR: 3.17, 95% CI: 2.80–3.59). In the adjusted analyses, the odds of EMS use were higher for uninsured children and lower for children with public insurance compared with children with private insurance [OR (95% CI): uninsured, 1.41 (1.12–1.78); public, 0.77 (0.65–0.90)]. The propensity score analysis showed similar results.

Conclusions
In contrast to adult patients, children with public insurance are less likely to use EMS than children with private insurance, even after adjustment for illness severity and other confounders.