bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Efficacy of Daratumumab Monotherapy and Pomalidomide Plus Low-Dose Dexamethasone in the Treatment of Multiple Myeloma: A Matching Adjusted Indirect Comparison
Authors: Van Sanden Suzy , Ito Tetsuro , Diels Joris , Vogel Martin , Belch Andrew , Oriol Albert 
Published: November 2017

Abstract

Background
Daratumumab (a human CD38-directed monoclonal antibody) and pomalidomide (an immunomodulatory drug) plus dexamethasone are both relatively new treatment options for patients with heavily pretreated multiple myeloma. A matching adjusted indirect comparison (MAIC) was used to compare absolute treatment effects of daratumumab versus pomalidomide + low-dose dexamethasone (LoDex; 40 mg) on overall survival (OS), while adjusting for differences between the trial populations.

Materials and Methods
The MAIC method reduces the risk of bias associated with naïve indirect comparisons. Data from 148 patients receiving daratumumab (16 mg/kg), pooled from the GEN501 and SIRIUS studies, were compared separately with data from patients receiving pomalidomide + LoDex in the MM-003 and STRATUS studies.

Results
The MAIC-adjusted hazard ratio (HR) for OS of daratumumab versus pomalidomide + LoDex was 0.56 (95% confidence interval [CI], 0.38–0.83; p = .0041) for MM-003 and 0.51 (95% CI, 0.37–0.69; p &lt; .0001) for STRATUS. The treatment benefit was even more pronounced when the daratumumab population was restricted to pomalidomide-naïve patients (MM-003: HR, 0.33; 95% CI, 0.17–0.66; p = .0017; STRATUS: HR, 0.41; 95% CI, 0.21–0.79; p = .0082). An additional analysis indicated a consistent trend of the OS benefit across subgroups based on M-protein level reduction (≥50%, ≥25%, and &lt;25%).

Conclusion
The MAIC results suggest that daratumumab improves OS compared with pomalidomide + LoDex in patients with heavily pretreated multiple myeloma.

Implications for Practice
This matching adjusted indirect comparison of clinical trial data from four studies analyzes the survival outcomes of patients with heavily pretreated, relapsed/refractory multiple myeloma who received either daratumumab monotherapy or pomalidomide plus low-dose dexamethasone. Using this method, daratumumab conferred a significant overall survival benefit compared with pomalidomide plus low-dose dexamethasone. In the absence of head-to-head trials, these indirect comparisons provide useful insights to clinicians and reimbursement authorities around the relative efficacy of treatments.
Educación intercultural y formación del profesorado
Authors: Lafuente Guantes Maria Isabel 
Published: November 2017

Este trabajo realiza una reflexión, desde la Filosofía de la Educación, sobre la situación de la educación intercultural en la sociedad global, entendiendo que ni la filosofía ni el filósofo están exentos de intereses, y de atender a los giros: cognoscitivo y lingüístico. Se expone la situación actual de dicha forma de educación, y se enuncian y examinan los principios (diálogo crítico y sociedad de la cooperación), finalidades (construcción de identidad, construcción de racionalidad, construcción de personalidad), y acciones (prácticas sociales), esenciales para la formación del profesorado en esta modalidad educativa, así como la necesidad de incluir en ella la formación investigativa. ______________ Contextualización: Idioma Maya Q’eqchi’ Contextualizador: Agustin Pelicó Pérez Ministerio de Educación de Guatemala K’OSB’IL NA’LEB’ Li k’anjel li wan sa’ li perel hu a’in, naxtz’il rix chan ru wan ut chan ru nak’utman li tzolok chirix li k’iilawank sa’ li junjunq chi nimla tzoleb’aal ut sa’ li junjunq chi tenamit. Ab’anan tento xnawb’al naq li naxtz’il rix li tzolok a’in, junelik naraj xnawb’al k’a’ru nak’ulman chirix li na’leb’ a’in, ut wan sa’ xb’een rilb’al ma us li k’iila paay chi na’leb’ ut li aatinob’aal li na’oksiman. Sa’ li perel hu a’in, naxk’ut chiruheb’ li poyanam naq jwal us li tzolok chirix li k’iilawank, xb’aan naq sa’ li junjunq chi tenamit moko jun ta li aatinob’aal wan, k’iila paay b’an eb’ li aatinob’aal li na’oksiman naq na’uxq li sum’aatinak. Jo’kan naq joq’e na’uxman li aatinak aajel ru xtz’ilb’al rix li k’a’ru nayeeman sa’ li tzolok. Eb’ li tenq’ li nake’xk’e li najtil tenamit, aajel ru rilb’al chi us, xb’aan naq li xk’anjel a’an re xtenq’ankileb’ li poyanam re naq ink’a’ te’xmajewa rib’ ut te’xloq’oni rib’. Li wan sa’ li perel hu a’in, taak’anjelak re xtenq’ankileb’ li ixq ut li winq li yookeb’ chi tzolok sa’ li nimla tzoleb’aal, chi xtzolb’al li na’leb’ chi rix li k’iilawank ut aajel ru aj wi’ naq te’xtzol ut te’xkawresi rib’ chirix li tz’ilok-ix. Eb’ li aatin tento xtzolb’al: li nab’aanuman sa’ li komonil; k’iila xpaayil xk’utb’al li tzolok; li tiikil wank, li k’iila xb’ehil k’utuk ut eb’ li loq’al.
Evaluating Within‐Plant Variability of Cotton Fiber Length and Maturity
Authors: Ayele Addissu G. , Kelly Brendan R. , Hequet Eric F. 
Published: November 2017

Core Ideas
Cultivars showed differences for the within‐plant fiber length and maturity.Some cultivars exhibited relatively stable within‐plant fiber length and maturity.Genetic component plays a significant role for the differences among the cultivars.
Previous studies have indicated differences in fiber quality parameters including fiber length and maturity within the canopy of cotton (Gossypium hirsutum L) plants. A 3‐yr study was conducted to investigate the impact of within‐plant variability on fiber length and maturity of upland cotton cultivars widely grown on the High Plains of Texas. Twelve upland cotton cultivars were grown in a randomized complete block design with three field replications, in Lubbock, TX, during the 2012, 2013, and 2014 growing seasons. A box‐picking harvesting method was used to individualize samples so that the within‐plant variability of cotton fiber quality could be studied. Bolls harvested from different positions on the plants were ginned with a tabletop roller gin to minimize fiber damage. The lint from each fruiting position was blended with a supple needles laboratory blender to reduce within‐sample variability while minimizing fiber breakage. Each sample collected from a different fruiting position on the plant was tested on the Advanced Fiber Information System (AFIS) with three replications of 3000 fibers. The results indicated that cultivars such as FM 9170 B2F, NG 4111 RF, PHY 499 WRF, and FM 2484 B2F showed lower within‐plant variability, while DP 1044 B2RF, PHY 367 WRF, and ST 5458 B2F showed relatively high within‐plant variability for AFIS fiber length and fiber maturity. In conclusion, variations in within‐plant fiber length and maturity among upland cotton cultivars could be a potential source of variability for breeding programs aimed at improving fiber quality.
Genetic Improvement of Key Agronomic Traits in Melilotus albus
Authors: Luo Kai , Jahufer M. Z. Z. , Zhao Hong , Zhang Rui , Wu Fan , Yan Zhuanzhuan , Zhang Jiyu , Wang Yanrong 
Published: November 2017

ABSTRACTMelilotus albus Medik. is a legume species with potential to be used as a forage or conserved fodder in Northwest China. Breeding M. albus as a forage crop is focused on simultaneously improving forage yield and reducing coumarin (Cou) content. The goal of the present study was to estimate genotypic variation for several key agronomic traits and to evaluate the impact of single‐trait selection and Smith–Hazel‐index‐based multitrait selection for herbage dry weight (DW), plant height (PH), stem number (SN), and leaf area (LA). A quantitative genetic analysis was conducted on trait measurements from 25 half‐sib (HS) families evaluated at Yuzhong and Linze, in China. Significant (P < 0.05) genotypic variation among the HS families for all traits was observed. There was also significant (P < 0.05) genotype × environment interaction for all traits except for LA. The predicted genetic gain, based on estimated genotypic variance, for single‐trait selection varied from 2.3 to 30.3% per selection cycle. Pattern analysis of the HS family × multitrait best linear unbiased prediction matrix provided a graphical summary of the association among the traits, as well as the four HS family groups generated from clustering. Some members within Group 1 could be crossed to generate a breeding population to be used in recurrent selection for M. albus cultivar development in Northwest China. The applicability of a Smith–Hazel selection index to increase expression of the traits DW, PH, and SN and reduce LA, indirectly reducing Cou content, was confirmed. This index enabled identification of families for increasing key biomass traits and decreasing Cou production.
Water Distribution in an Arid Zone Soil: Numerical Analysis of Data from a Large Weighing Lysimeter
Authors: Dijkema J. , Koonce J.E. , Shillito R.M. , Ghezzehei T.A. , Berli M. , van der Ploeg M.J. , van Genuchten M.Th. 
Published: November 2017

Core Ideas
We aimed to advance our mechanistic understanding of desert soil hydrodynamics.
We calibrated and validated a HYDRUS‐1D software version on desert soil data from a weighing lysimeter.
HYDRUS‐1D is an attractive tool for virtual experiments relevant for arid ecosystems.
Although desert soils cover approximately one third of the Earth's land surface, surprisingly little is known about their physical properties and how those properties affect the ecology and hydrology of arid environments. The main goal of this study was to advance our understanding of desert soil hydrodynamics. For this purpose, we developed a process‐based component within HYDRUS‐1D to describe the moisture dynamics of an arid zone soil as a function of water fluxes through the soil surface. A modified van Genuchten model for the dry end of the soil water retention curve was developed to better capture the basic flow processes for very dry conditions. A scaling method was further used to account for variabilities in water retention because of changes in the bulk density vs. depth. The model was calibrated and validated using hourly soil moisture, temperature, and mass data from a 3‐m‐deep weighing lysimeter of the Scaling Environmental Processes in Heterogeneous Arid Soils facility at the Desert Research Institute (Las Vegas, NV). Measurements and simulations during a 1‐yr period agreed better under precipitation (wetting) than under evaporation (drying) conditions. Evaporation was better simulated for wet than for dry soil surface conditions. This was probably caused by vapor‐phase exchange processes with the atmosphere, which were unaccounted for and need to be further explored. Overall, the model provides a promising first step toward developing a more realistic numerical tool to quantify the moisture dynamics of arid ecosystems and their role in climate change, plant growth, erosion, and recharge patterns.
L’accouchement naturel contre l’hôpital moderne ?
Authors: Quagliariello Chiara 
Published: November 2017

L’accouchement dit « naturel » est l’une des réponses qui se sont progressivement présentées comme alternatives possibles à l’hypermédicalisation des naissances depuis les années 1980. L’article analyse ce modèle de naissance en se basant sur les résultats d’une recherche ethnographique réalisée en Toscane, dans l’une des premières maternités à avoir introduit l’accouchement naturel en Italie. Dans la première partie, il s’agit de montrer les liens entre l’histoire singulière de cette maternité et le mouvement plus large de critiques à l’égard de la médicalisation croissante de l’assistance aux femmes. L’analyse de l’accouchement naturel nous conduit ensuite à observer les évolutions de cette pratique au cours du temps ; nous portons une attention particulière au rôle joué par les sages-femmes dans ce processus. Enfin, nous réfléchissons aux formes que prend l’idée de nature dans ce modèle de naissance et au sens que les femmes concernées donnent à leur choix d’accoucher autrement au sein même de l’espace hospitalier.
Solubility‐Parameter‐Guided Solvent Selection to Initiate Ostwald Ripening for Interior Space‐Tunable Structures with Architecture‐Dependent Electrochemical Performance
Authors: Mao Baoguang , Guo Donglei , Qin Jinwen , Meng Tao , Wang Xin , Cao Minhua 
Published: November 2017

AbstractDespite significant advancement in preparing various hollow structures by Ostwald ripening, one common problem is the intractable uncontrollability of initiating Ostwald ripening due to the complexity of the reaction processes. Here, a new strategy on Hansen solubility parameter (HSP)‐guided solvent selection to initiate Ostwald ripening is proposed. Based on this comprehensive principle for solvent optimization, N,N‐dimethylformamide (DMF) was screened out, achieving accurate synthesis of interior space‐tunable MoSe2 spherical structures (solid, core–shell, yolk‐shell and hollow spheres). The resultant MoSe2 structures exhibit architecture‐dependent electrochemical performances towards hydrogen evolution reaction and sodium‐ion batteries. This pre‐solvent selection strategy can effectively provide researchers great possibility in efficiently synthesizing various hollow structures. This work paves a new pathway for deeply understanding Ostwald ripening.
The Effect of the Dielectric Constant and Ion Mobility in Light‐Emitting Electrochemical Cells
Authors: Bastatas Lyndon D. , Moore Matthew D. , Slinker Jason D. 
Published: November 2017

AbstractLight‐emitting electrochemical cells (LEECs) are a promising low‐cost option for display and solid‐state lighting. In these devices, the interplay of mobile ions, electrons, and holes makes for rich physics that can be leveraged for high performance. One example of this interplay is in the formation and radiative decay of excitons–bound electron and hole pairs. Considerations from exciton binding and Langevin recombination suggest that a low dielectric constant (ϵ) would enhance emission. However, emission is also enhanced by the product of the bulk hole and electron concentrations, which in LEECs are enhanced by the motion of small mobile ions yielding high dielectric constants. These competing effects make it difficult to predict whether active layers with low or high dielectric constants will optimize device performance. Here, the effect of varying the dielectric constant on the performance of LEEC devices from ionic transition‐metal complexes was studied by systematically exchanging the negative counterions paired with an iridium complex emitter. Electrochemical impedance spectroscopy, constant voltage and constant current device studies, and drift‐diffusion simulations were performed. The results clarify the competing effects of Langevin bimolecular recombination and ion‐assisted injection processes occurring in LEECs.
Simultaneous Detection of Protein and mRNA in Jurkat and KG‐1a Cells by Mass Cytometry
Authors: Mavropoulos Anastasia , Allo Bedilu , He Mingxiao , Park Emily , Majonis Daniel , Ornatsky Olga 
Published: November 2017

AbstractMass cytometry uniquely enables high‐dimensional single‐cell analysis of complex populations. This recently developed technology is based on inductively coupled time‐of‐flight mass spectrometry for multiplex proteomic analysis of more than 40 markers per cell. The ability to characterize the transcriptome is critical for the understanding of disease pathophysiology, medical diagnostics, and drug discovery. Current techniques allowing the in situ detection of transcripts in single cells are limited to a small number of simultaneous targets and are generally tedious and labor‐intensive. In this report, we present the development of a multiplex method for targeted RNA detection by combining the mass cytometry and RNAscope® platforms. This novel assay, called Metal In Situ Hybridization (MISH), includes the hybridization of RNA‐specific target probes followed by signal amplification achieved through a cascade of hybridization events, ending with the binding of amplifier‐specific detector probes. The detector probes are tagged with isotopically pure metal atoms used for detection by mass cytometry. Proof‐of‐principle experiments show the simultaneous detection of three mRNA targets in Jurkat cells in suspension cell assay mode. The localization of transcripts was also investigated using the imaging mass cytometry platform in Jurkat and KG‐1a cells. In addition, we optimized the antibody staining procedure to allow the co‐detection of mRNA and cell surface markers. Our data demonstrate that MISH can be used to complement protein detection by mass cytometry as well as to investigate gene transcription and translation in single cells. © 2017 International Society for Advancement of Cytometry
Advanced Metal Oxide@Carbon Nanotubes for High‐Energy Lithium‐Ion Full Batteries
Authors: Ming Hai , Zhou Hong , Zhu Xiayu , Zhang Songtong , Zhao Pengcheng , Li Meng , Wang Limin , Ming Jun 
Published: November 2017

AbstractA strategy to synthesize a Fe3O4@carbon nanotube (CNT) composite with high tap density of 1.22 g cm−3 and electronic conductivity of 4.1 S cm−1 is developed. The Fe3O4@CNT composite exhibits an extremely high capacity of over 1263 mAh g−1, even after 125 cycles at a current density of 100 mA g−1. Additionally, a lithium‐ion full battery of Fe3O4@CNT|LiNi0.5Mn1.5O4 with an energy density of 2283 Wh kganode−1 (381 Wh kgcathode−1) is successfully configured. After optimization of the work voltage windows and electrolyte additives, it has a capacity retention of 71 % after more than 400 cycles. Using this synthetic strategy, additional metal oxide@CNT (e.g., Co3O4, MnO2, CuO, ZnO) composites with high lithium storage capability are explored, and their electrochemical differences versus the cathode of LiNi0.5Mn1.5O4 are investigated in light of their superior performances. Applying this type of metal oxide‐based composite in full cells is a significant step to the development of high‐energy lithium‐ion batteries and to further applications in current sodium‐ion batteries.
Expeditious emergency room referral pathway improves patient access to otolaryngology care
Authors: Johnson Jeffrey , Jiang Zi Yang , Martinez Daniel , Smith David , Curtis Elizabeth , Robinson David , Alava Ibrahim 
Published: November 2017

ObjectivesHistorically at a multi‐hospital residency program, there was an unexpected number of non‐urgent consults from the county hospital emergency room (ER) that caused residents to make more trips between hospitals and come closer to violating duty hours. Moreover, there was also a poor follow‐up rate for these patients. An alternate pathway to redirect such consults to the Otorhinolaryngology–Head and Neck Surgery (ORL–HNS) clinic, staffed by an attending physician, was devised. This study illustrates how an undemanding process change can improve access to care, and resident duty hours and satisfaction.Study DesignQuality Improvement StudyMethodsThe average rate of no‐show appointments and overall number of patients referred from the county hospital ER; a survey of impact on resident workload; and an average number of on‐call resident trips to county hospital were compared in the 12 months before and after implementation of an expedited ER referral pathway.ResultsThe overall number of patients referred to clinic from ER increased by 35% (123 to 166 patients). The average number of completed visits for patients referred to the ORL‐HNS clinic from the ER increased by 29% (91 to 117 patients). There was no statistically significant change in the no‐show rate of said patients. The average number of overnight resident trips to the county hospital, frequency of resident unpreparedness for routine clinical duty and need to alter schedule to avoid duty hour violations all decreased, while resident satisfaction increased.ConclusionsAn undemanding process change in a safety‐net, publicly‐funded, county hospital setting can decrease resident workload and improve satisfaction while possibly improving patient access to specialty clinic care and follow‐up rates for patients.Level of Evidenceclinical outcomes, level IV
A presentation theorem for continuous logic and metric abstract elementary classes
Authors: Boney Will 
Published: November 2017

AbstractIn recent years, model theory has widened its scope to include metric structures by considering real‐valued models whose underlying set is a complete metric space. We show that it is possible to carry out this work by giving presentation theorems that translate the two main frameworks (continuous first order logic and Metric Abstract Elementary Classes) into discrete settings (a nice fragment of and Abstract Elementary Classes, respectively). We also translate various notions of classification theory.
Large-scale join-idle-queue system with general service times
Authors: Foss S. , Stolyar A. L. 
Published: November 2017

Abstract
A parallel server system with n identical servers is considered. The service time distribution has a finite mean 1 / μ, but otherwise is arbitrary. Arriving customers are routed to one of the servers immediately upon arrival. The join-idle-queue routeing algorithm is studied, under which an arriving customer is sent to an idle server, if such is available, and to a randomly uniformly chosen server, otherwise. We consider the asymptotic regime where n → ∞ and the customer input flow rate is λn. Under the condition λ / μ < ½, we prove that, as n → ∞, the sequence of (appropriately scaled) stationary distributions concentrates at the natural equilibrium point, with the fraction of occupied servers being constant at λ / μ. In particular, this implies that the steady-state probability of an arriving customer waiting for service vanishes.
The distribution of refracted Lévy processes with jumps having rational Laplace transforms
Authors: Zhou Jiang , Wu Lan 
Published: November 2017

Abstract
We consider a refracted jump diffusion process having two-sided jumps with rational Laplace transforms. For such a process, by applying a straightforward but interesting approach, we derive formulae for the Laplace transform of its distribution. Our formulae are presented in an attractive form and the approach is novel. In particular, the idea in the application of an approximating procedure is remarkable. In addition, the results are used to price variable annuities with state-dependent fees.
Apparent Diffusion Coefficient (ADC) predicts therapy response in pancreatic ductal adenocarcinoma
Authors: Trajkovic-Arsic M. , Heid I. , Steiger K. , Gupta A. , Fingerle A. , Wörner C. , Teichmann N. , Sengkwawoh-Lueong S. , Wenzel P. , Beer A. J. , Esposito I. , Braren R. , Siveke J. T. 
Published: November 2017

AbstractRecent advances in molecular subtyping of Pancreatic Ductal Adenocarcinoma (PDAC) support individualization of therapeutic strategies in this most aggressive disease. With the emergence of various novel therapeutic strategies and neoadjuvant approaches in this quickly deteriorating disease, robust approaches for fast evaluation of therapy response are urgently needed. To this aim, we designed a preclinical imaging-guided therapy trial where genetically engineered mice harboring endogenous aggressive PDAC were treated with the MEK targeting drug refametinib, which induces rapid and profound tumor regression in this model system. Multi-parametric non-invasive imaging was used for therapy response monitoring. A significant increase in the Diffusion-Weighted Magnetic Resonance Imaging derived Apparent Diffusion Coefficient (ADC) was noted already 24 hours after treatment onset. Histopathological analyses showed increased apoptosis and matrix remodeling at this time point. Our findings suggest the ADC parameter as an early predictor of therapy response in PDAC.