bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring emotional well-being, spiritual, religious and personal beliefs and telomere length in chronic pain patients—A pilot study with cross-sectional design
Authors: Rönne-Petersén Linn , Niemi Maria , Walach Harald , Lavebratt Catharina , Yang Liu L. , Gerdle Björn , Ghafouri Bijar , Falkenberg Torkel 
Published: September 2024

Living with chronic pain is associated with substantial suffering and high societal costs. Patient reported outcomes (PROM’s) and cellular ageing should be considered in pain management. The aim of this study was to explore correlations of PROM’s and cellular ageing (telomere length [TL] and telomerase activity [TA]) amongst patients with chronic non-malignant pain. This was an explorative pilot study with cross-sectional design and recruitment was done at two pain rehabilitation facilities in Sweden, with inpatient setting/integrative care and outpatient setting/multimodal care, respectively. Eighty-four patients were enrolled by referral to pain rehabilitation in Sweden. The main outcome measures collected after admission in addition to TL and TA were the following PROMs: Numerical Rating Scale (NRS), Chronic Pain Acceptance Questionnaire (CPAQ), Hospital Anxiety and Depression Scale (HADS), Five Facets Mindfulness Questionnaire (FFMQ), WHO Quality of Life–Spiritual, Religious and Personal Beliefs (WHOQoL-SRPB) and EuroQol 5 Dimensions (EQ-5D). All the PROM’s showed evidence of poor overall health status among the participants. TL correlated negatively with HADS score (r = -.219, p = .047) and positively with WHOQoL-SRPB (r = .224, p = .052). TL did not correlate with any of the pain measures. TA correlated positively with pain spread (r = .222, p = .049). A mediation of the direct effect of spiritual well-being on TL by anxiety and depression could be shown (b = 0.008; p = .045). The correlations between TL and SRPB and anxiety and depression suggest some importance of emotional and SRPB dimensions in pain management, with implications for cellular aging, which may warrant further study.
Trial registration: ClinicalTrials.gov Identifier: NCT02459639.
Meta Analisis: Efektivitas Cognitive Behavioral Therapy untuk Insomnia
Authors: Rahma Lili , Yudiarso Ananta 
Published: September 2024

Insomnia cases in Indonesia and worldwide as well have increased every year. Based on data found cases of insomnia increased during the COVID-19 pandemic. The intervention that is widely used in dealing with insomnia is by using cognitive behavioral therapy (CBT) intervention techniques. Several previous studies have conducted research related to CBT for insomnia (CBT-I). This research was conducted to see the magnitude of the effect size arising from CBT on insomnia and to increase statistical insight using meta-analysis approach of hedge's g. The study used 14 research journal articles discussing cognitive behavioral therapy and insomnia which involved total of 7085 respondents. The results of this study found that cognitive behavioral therapy was quite effective in reducing insomnia (g=-0.57).

Kasus insomnia di Indonesia maupun di dunia mengalami peningkatan setiap tahunnya. Berdasarkan data yang ditemukkan kasus insomnia bertambah selama masa pandemi COVID-19 berlangsung. Intervensi yang banyak digunakan dalam menangani insomnia adalah dengan menggunakan teknik intervensi cognitive behavioral therapy (CBT). Beberapa penelitian terdahulu sudah melakukan penelitian berkaitan dengan CBT untuk insomnia (CBT-I). Penelitian ini dilakukan untuk melihat besaran effect sizeyang ditimbulkan dari CBT terhadap insomnia serta meningkatkan wawasan statistik dengan menggunakan meta-analisis. Pada penelitian ini menggunakan metode meta-analisis yang mana dalam analisisnya menggunakan aplikasi JAMOVI versi 2.2.5 dana melihat effect size menggunakan nilai hedge’s g. penelitian menggunakan 14 artikel jurnal penelitian yang membahas mengenai cognitive behavioral therapy dan insomnia yang mana melibatkan sebanyak 7085 responden. Hasil dari penelitian ini menemukkan bahwa cognitive behavioral therapy cukup efektif dalam menurunkan insomnia (g=-0.57).
Perilaku Mencari Perhatian pada Remaja Akhir dengan Latar Belakang Keluarga Broken Home
Authors: Syahrani Alifia , Palila Sara 
Published: September 2024

Tantangan yang berbeda dihadapi oleh remaja yang hidup dalam keluarga bermasalah yang sering disebut dengan keluarga broken home. Satu di antaranya adalah bagaimana mereka cenderung lebih banyak mencari perhatian dari orang sekitar. Tujuan penelitian ini adalah ingin melihat bagaimana gambaran perilaku mencari perhatian pada remaja yang berada dalam keluarga broken home. Penelitian ini menggunakan metode kualitatif dengan pendekatan fenomenologi. Data dikumpulkan melalui teknik wawancara dan dokumentasi terhadap tiga orang informan dengan kondisi keluarga broken home yang berbeda. Penelitian memberikan hasil bahwa perilaku mencari perhatian pada informan beragam, baik yang bentuknya negatif seperti menyakiti diri maupun positif yang berwujud pada dorongan belajar dan berprestasi yang tinggi. Hal yang mungkin berpengaruh adalah bentuk broken home yang dialami, pengaruh lingkungan sekitar, maupun kondisi internal dari remaja itu sendiri. Hasil penelitian ini diharapkan dapat menjadi dasar untuk mengembangkan rancangan modul intervensi yang dapat membantu remaja yang hidup dari keluarga broken mengelola dorongan mencari perhatian agar termanifestasi dalam perilaku yang lebih adaptif.

Different challenges are faced by teenagers who live in problematic families which are often called broken homes. One of them is how they tend to seek more attention from the people around them. The aim of this research is to explore the attention-seeking behavior of teenagers in broken home. This research uses a qualitative method with a phenomenological approach. Data was collected through interview and documentation techniques from three informants with different broken home family conditions. The research showed that attention-seeking behavior of the informants varied, both in negative forms such as self–harm and positive ones in the form of encouragement for learning and high achievement. Factors that may have an influence are the form of broken home experienced, surrounding environment, and internal condition of the teenager theirself. It is hoped that the result of this research can be the basis for developing intervention designs that can help adolescents living from broken families manage the urge to seek attention thus it manifests in more adaptive behavior.
Transcriptional and morphological responses following distinct muscle contraction protocols for Snell dwarf (Pit1dw/dw) mice
Authors: Rader Erik P. , McKinstry Kimberly A. , Baker Brent A. 
Published: September 2024

AbstractThe Snell dwarf mouse (Pit1dw/dw), an animal model of congenital combined pituitary hormone deficiency, displays skeletal muscle weakness. While enhanced responsivity to repeated exposures of muscle contractions have been documented for Snell dwarf mice, the response following single exposure to distinct contraction protocols remained uncharacterized. The purpose of this study was to investigate the muscle recovery of Snell dwarf and control littermate mice following a single exposure to two separate protocols—an intermittent slow velocity (30°/s) contraction protocol or a continuous rapid velocity (500°/s) contraction protocol. Following both protocols for control mice, torque values were 30% and 80% of pre‐protocol values at 5 min and 3 days, respectively. At 10 days, performance returned to baseline for the 30°/s protocol and were depressed for the 500°/s protocol. For Snell dwarf mice following both protocols, torques were depressed to 5% of pre‐protocol values at 5 min and returned to baseline by 3 days. Recovery following the 30°/s protocol for control mice and both protocols for Snell dwarf mice coincided with increased transcriptional output, upregulation of cytokine‐mediated signaling genes, and a distribution shift to smaller muscle fibers with reduced area per nucleus. These features represent efficacious remodeling ubiquitous across distinct contraction paradigms in the context of thePit1mutation.
Impact of surgical aortic valve replacement and transcatheter aortic valve implantation on cardiovascular and cerebrovascular controls: A pilot study
Authors: Bari Vlasta , Gelpi Francesca , Cairo Beatrice , Anguissola Martina , Acerbi Elena , Squillace Mattia , De Maria Beatrice , Bertoldo Enrico Giuseppe , Fiolo Valentina , Callus Edward , De Vincentiis Carlo , Bedogni Francesco , Ranucci Marco , Porta Alberto 
Published: September 2024

AbstractSurgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) are options in severe aortic valve stenosis (AVS). Cardiovascular (CV) and cerebrovascular (CBV) control markers, derived from variability of heart period, systolic arterial pressure, mean cerebral blood velocity and mean arterial pressure, were acquired in 19 AVS patients (age: 76.8 ± 3.1 yrs, eight males) scheduled for SAVR and in 19 AVS patients (age: 79.9 + 6.5 yrs, 11 males) scheduled for TAVI before (PRE) and after intervention (POST, <7 days). Left ventricular function was preserved in both groups. Patients were studied at supine resting (REST) and during active standing (STAND). We found that: (i) both SAVR and TAVI groups featured a weak pre‐procedure CV control; (ii) TAVI ensured better CV control; (iii) cerebral autoregulation was working in PRE in both SAVR and TAVI groups; (iv) SAVR and TAVI had no impact on the CBV control; (v) regardless of group, CV and CBV control markers were not influenced by STAND in POST. Even though the post‐procedure preservation of both CV and CBV controls in TAVI group might lead to privilege this procedure in patients at higher risk, the missing response to STAND suggests that this advantage could be insignificant.
Four eyes, two truths: Explaining heterogeneity in perceived severity of digital hate against immigrants
Authors: Kirchmair Thomas , Koban Kevin , Matthes Jörg 
Published: September 2024

Abstract
Drawing on theories related to interpersonal and intergroup behavior, this study investigated effects of personality traits (i.e., empathy and identity insecurity) and attitudes (i.e., anti-migration attitudes and social dominance orientation) on the perceived severity of digital hate against immigrants in Austria. Findings of autoregressive path modeling using two-wave panel data revealed that empathic suffering and egalitarianism positively predicted perceived severity, while anti-migrant attitudes exhibited a negative prediction. In terms of interactions between personality and attitudes, we observed that the prediction of empathic suffering becomes less relevant for egalitarian individuals, which indicates an overwriting process that might be a promising way to counteract socially harmful digital hate perceptions. Implications for research on annotation tasks and hate interventions are discussed.
Effectiveness of nutritional support for clinical outcomes in gastric cancer patients: A meta-analysis of randomized controlled trials
Authors: Zhang Juping , Kong Qian , Zhang Jibo , Guo Jun 
Published: September 2024

Abstract

Background
Gastric cancer (GC) is a leading cause of cancer-related morbidity and mortality globally. This meta-analysis was conducted to assess the impact of nutritional interventions on clinical outcomes in GC patients.

Methods
Comprehensive search was conducted across four medical databases to identify randomized controlled trials (RCTs) that examined nutritional interventions in GC patients. The outcomes assessed included hospitalization duration, nutritional status, immune function, and complications.

Results
A total of 11 studies were included. Enteral nutrition (EN) significantly reduce hospital stay duration compared to no nutritional intervention (SMD = −1.22, 95% CI [−1.72, −0.73], P < 0.001) and parenteral nutrition (PN) (SMD = −1.30, 95% CI [−1.78, −0.82], P < 0.001), but showed no significant difference compared to immunonutrition (IN). EN also improved nutritional status, indicated by higher albumin prealbumin levels, and improved immune function by elevating CD4+ levels (SMD = 1.09, 95% CI [0.61, 1.57], P < 0.001). However, IN showed superior effects on immunoglobulin levels (IgG and IgM). No significant differences were observed in complication rates among EN, IN, and PN interventions.

Conclusion
Nutritional support, particularly EN and IN, can significantly improve hospitalization outcomes, nutritional status, and immune function. Customizing interventions according to patient requirements can optimize therapeutic outcomes, highlighting the need for further research in this area.
Wear mechanism analysis of internal chip removal drill for CFRP drilling
Authors: Xu Chengyang , Liu Xueqing , Li Fujia , Fu Heguo , Han Dong , Huang Ning , Wang Gongdong , Wang Yiwen 
Published: September 2024

Abstract
As one of the main problems in the processing of carbon fiber reinforced polymer (CFRP), tool wear affects the quality and efficiency of hole making. As a new CFRP hole making process, the suction-type internal chip removal method can effectively slow down the tool wear rate. In order to further clarify the reasons for this method to slow down the tool wear, this study investigates the wear mechanism of the internal chip removal tool. The main contents include: first, the experimental parameters such as drilling axial force, drilling temperature, and tool wear are obtained through the experimental method, and the drawing of the drilling temperature change curve of internal chip drilling is completed; second, the polar analysis method is used to study the influence of the drill parameters on the drilling axial force and the tool wear, and the basis for the selection of the structure of the internal chip drill is given; finally, the method of comparative experiments of the internal chip drilling process and the non-internal chip drilling process is used to conclude that the use of the internal chip drilling process can effectively slow down the tool wear rate. Finally, the method of comparing the internal chip removal and non-internal chip removal processes is used to conclude that the use of internal chip removal processing method can effectively reduce the axial force, drilling temperature, and slow down the tool wear.
ФУНКЦИОНАЛЬНЫЙ РЕСУРС СЕТЕВЫХ КОММУНИКАЦИЙ И ОБЩЕСТВЕННО-ГОСУДАРСТВЕННОЕ ВЗАИМОДЕЙСТВИЕ
Authors: ПЕРЕПЕЛИЦА Елена Васильевна 
Published: September 2024

Взаимодействие в прокси-режиме дает массу неоценимых преимуществ и практических улучшений. Общество информационно-цифровых коммуникаций переживает решительные перемены. Однако прогресс взаимоотношений между людьми не достигается технологическими способами, как полагали и декларировали техноутописты. Изобилие онлайн-платформ не обращает оппонентов в единомышленников и автоматически не снимает разногласия. Под действием прорывных технологий возможны преображения и падения. Коммуникационные средства не вдохнули новые жизненные силы в демократию, их ресурс позволяет имитировать бурную гражданскую активность и принимать нужные, заведомо согласованные решения, минуя какую-либо общественную верификацию. Опыт различных государств, в том числе технологически преуспевающих, показывает, что делиберативное участие граждан в публичном дискурсе — желаемое состояние и одновременно задача огромной степени сложности, окончательных способов решения которой пока нет.
Сетевые коммуникации используются, как правило, монофункционально, а именно для передачи информации от государства — обществу, отчасти поэтому высокая технологическая оснащенность управленческих структур принципиально не меняет степень участия граждан в разработке юридически значимых решений. Посчитав смысл коммуникации окончательно раскрытым и равным передаче-получению информации, мы не даем себе труда расширить рамки анализа онлайн-взаимодействия. Тем не менее интеракции с участием людей настраиваются по более тонкому и чувствительному камертону, нежели (пере)направление контента между высокотехнологическими устройствами. В этой связи предлагается посмотреть немного иначе на правовую сущность сетевых коммуникаций — не так, как это принято в информационном праве. Функциональный ресурс сетевых коммуникаций может служить обеспечению доступности процесса разработки и принятия юридически значимых решений, демократизации юридических процедур, созданию действенных механизмов обратной связи и контроля. Утверждается, что глубокое знание природы социального взаимодействия позволит употреблять функционал технологических инноваций в созидательном ключе и выстраивать релевантную модель правового регулирования удаленных общественно-государственных интеракций.
ПОСТРОЕНИЕ И АВТОМАТИЗАЦИЯ БИЗНЕС-ПРОЦЕССОВ УПРАВЛЕНИЯ ПРАВАМИ НА ТЕХНОЛОГИИ
Authors: НАУМОВ Виктор Борисович 
Published: September 2024

Обобщен обширный многолетний опыт реализации проектов по созданию систем управления интеллектуальной собственностью и правами на технологии в крупных российских промышленных, технологических и финансовых холдингах. Представлена и проанализирована методология управления интеллектуальной собственностью и приведены ее основные объекты, даны характеристики процессов принятия решения в сфере управления нематериальными активами и приведены примеры автоматизации соответствующих бизнес-процессов. Рассмотрены теоретико-правовые вопросы охраны прав на технологии.
Vocational Education: The New Development and Change in the Adaptive Curriculum of Learning Model
Authors: Barliana M. Syaom , Alhapip Leli , Ana Ana , Rahmawati Yulia , Muktiarni Muktiarni , Dwiyanti Vina 
Published: September 2024

The challenges with vocational education are that graduates are not prepared to work because they do not have the competencies required by the business industry. The graduates from vocational high school have a high unemployment rate because the curriculum is not in line with the needs of the business industry and also graduates standards are quite low. The research aimed to find a solution to these problems. One of the solutions that could be explored was by implementing an integrated learning curriculum model in vocational education. Adaptive curriculum policy is a curriculum that is modified and adapted when necessary, and each educational unit is allowed to innovate. The research method used was a systematic literature review on journals from the last ten years relating to adaptive curriculum and vocational education. The result showed that learning with an integrated curriculum model explored the greatest potential of teachers and students to innovate and improve the quality of learning independently. This promotes the development of working opportunities in the business and industrial sectors, creating high-quality of vocational school graduates with a high degree of skills and characters to become professional workers that are ready to compete in the global era and also creating confident graduates who have the entrepreneurial capacity.
Improving Architectural Drawing Students' Achievement by Coalescing Computer-Aided Design with the Compass Method
Authors: Olabiyi Oladiran Stephen 
Published: September 2024

This study combined computer-aided design with compass approaches, employing quasi-experimental design pre-test, post-test, and a non-equivalent control group, to improve the cognitive performance of architectural drawing students. The study addressed three objectives and investigated three null hypotheses. Thestudy's target audience was 125 senior secondary year two architectural drawing students. The experimental group received ten weeks of training using the marker board compass approach, while the control group received ten weeks of instruction using computer-aided design. Data was collected using the Architectural Drawing Achievement Test, which has a reliability rate of 0.86 using Kuder-Richardson 21. Three experts validated the test's face and content. The results revealed that the experimental group's students performed more effectively at architectural drawing than those in the control group. The cognitive achievement of students is significantly influenced by gender, favouring males. Additionally, in the area of architectural drawing, high-achievers students outperformed lowachievers students by barely. Based on these results, it was suggested that senior secondary schools in Nigeria teach architectural drawing using a combination of computer-aided design and the compass method.
Difficulties of primary diagnosis in patients with suspected systemic mastocytosis
Authors: Abdulkhalikova Z. K. , Barabanshchikova M. V. , Baykov V. V. , Barkhatov I. M. , Morozova E. V. , Moiseev I. S. 
Published: September 2024

Background. Mastocytosis is a rare myeloproliferative disease based on clonal hematopoiesis of mast cells, with accumulation of mast cells in various tissues and organs. The cutaneous mastocytosis is common in the pediatric population and, in general, progression to aggressive forms is not typical. In the adult population, there is systemic mastocytosis with a predominance of indolent and smoldering forms according to the literature, but there aren’t epidemiological data for the Russian Federation.Aim. To evaluate the results of primary diagnostics obtained during the examination of 70 patients with suspected systemic mastocytosis.Materials and methods. The histological studies of the skin and bone marrow, mutations in the c-kit gene in the bone marrow and serum tryptase level were examined in the Raisa Gorbacheva Memorial Research Institute for Pediatric Oncology, Hematology and Transplantation in accordance with WHO 2017 criteria.Results. The diagnostic results of 70 patients with suspected mastocytosis, the diagnosis was confirmed in 71.4 % (n = 50) of patients, of which systemic mastocytosis accounted for 82 % (n = 41). The 2 most common categories were identified: indolent systemic mastocytosis in 23 (56 %) patients and widespread forms in 15 (36.5 %), with a median time of diagnosis of 12 and 5 years, respectively.Conclusion. The late diagnosis is noted in all subgroups of systemic mastocytosis.
Mosunetuzumab for relapsed or refractory follicular lymphoma: a case study
Authors: Krylova Ya. V. , Kondakova E. V. , Gavrilenko A. N. , Chekalov A. M. , Fedorova L. V. , Stelmakh L. V. , Babenko E. V. , Shchegoleva T. S. , Gusak A. A. , Baykov V. V. , Mikhailova N. B. , Kulagin A. D. 
Published: September 2024

Recent advances in the diagnosis and understanding of follicular lymphoma (FL) pathogenesis have had a significant impact on therapeutic tactics. The life expectancy of patients has increased significantly. Currently, the 5-year overall survival of FL patients achieved 90 %, and its median is approaching 20 years. However, FL remains an incurable disease with periods of remission and relapse, requiring multiple therapy courses throughout the patient’s life.The main problem is the treatment of patients with refractory/relapsed forms, especially after 3rd line of therapy, as well as with a primarily resistant course and early (in the first 2 years) relapses. Therefore, despite the indolent FL course in most patients, there remains a need for new drugs that can ensure increased treatment efficacy with minimal toxicity and simultaneously maintain a high quality of life, mainly in the presence of primary refractoriness, early progression and in later lines of therapy. In recent years, new targeted drugs have been studied – phosphoinositide 3-kinase, enhancer of zeste homolog 2 inhibitors, as well as immunological drugs (CAR-T therapy (CAR – chimeric antigen receptor) and bispecific antibodies).The article presents the possibilities of treatment for refractory/relapsed FL as 3rd and subsequent therapy lines.