bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progress in Designing Therapeutic Antimicrobial Hydrogels Targeting Implant‐associated Infections: Paving the Way for a Sustainable Platform Applied to Biomedical Devices
Authors: Dini Caroline , Borges Maria Helena Rossy , Malheiros Samuel Santana , Piazza Rodolfo Debone , van den Beucken Jeroen J.J.P. , de Avila Erica Dorigatti , Souza João Gabriel S. , Barão Valentim A. R. 
Published: October 2024

AbstractImplantable biomedical devices have found widespread use in restoring lost functions or structures within the human body, but they face a significant challenge from microbial‐related infections, which often lead to implant failure. In this context, antimicrobial hydrogels emerge as a promising strategy for treating implant‐associated infections owing to their tunable physicochemical properties. However, the literature lacks a comprehensive analysis of antimicrobial hydrogels, encompassing their development, mechanisms, and effect on implant‐associated infections, mainly in light of existing in vitro, in vivo, and clinical evidence. Thus, this review addresses the strategies employed by existing studies to tailor hydrogel properties to meet the specific needs of each application. Furthermore, this comprehensive review critically appraises the development of antimicrobial hydrogels, with a particular focus on solving infections related to metallic orthopedic or dental implants. Then, preclinical and clinical studies centering on providing quantitative microbiological results associated with the application of antimicrobial hydrogels are systematically summarized. Overall, antimicrobial hydrogels benefit from the tunable properties of polymers and hold promise as an effective strategy for the local treatment of implant‐associated infections. However, future clinical investigations, grounded on robust evidence from in vitro and preclinical studies, are required to explore and validate new antimicrobial hydrogels for clinical use.
Bioengineered Extracellular Vesicles Delivering siMDM2 Sensitize Oxaliplatin Therapy Efficacy in Colorectal Cancer
Authors: Li Yunlong , Liu Zhiyuan , Wang Ping , Gu Xuerong , Ling Fei , Zhong Jiayuan , Yin Dong , Liu Rui , Yao Xueqing , Huang Chengzhi 
Published: October 2024

AbstractOxaliplatin (OXA) is the first‐line drug for the treatment of colorectal cancer (CRC), and susceptibility to drug resistance affects patient prognosis. However, the exact underlying mechanisms remain unclear. Platinum‐acquired resistance in CRC is a continuous transition process; though, current research has mainly focused on the end state of drug resistance, and the early events of drug resistance have been ignored. In this study, single‐cell transcriptome sequencing is combined with a dynamic network biomarker (DNB), and found that the functional inhibition of the mitochondrial electron transport chain complex I occur early in the development of attained resistance to OXA in CRC cells, as evidenced by a decrease in the levels of subunit proteins, primarily NDUFB8. Specifically, the mouse double minute 2 homologue (MDM2) mediates the ubiquitination and degradation of NDUFB8, reducing intracellular reactive oxygen species (ROS) generation under chemotherapeutic stress, consequently contributing to drug resistance. Based on this, the study constructs engineered extracellular vesicles carrying siMDM2 by electroporation and validates the application of EV‐siMDM2 to improve the efficacy of OXA‐based chemotherapy by inhibiting the MDM2/NDUFB8/ROS signaling axis in patient‐derived xenograft (PDX) and hepatic and pulmonary metastasis mouse models, thus providing new ideas and an experimental basis for the platinum‐resistant treatment of CRC.
Regulation of Wide Bandgap Perovskite by Rubidium Thiocyanate for Efficient Silicon/Perovskite Tandem Solar Cells
Authors: Wang Zhenhan , Han Zhaoyang , Chu Xinbo , Zhou Haitao , Yu Shiqi , Zhang Qian , Xiong Zhuang , Qu Zihan , Tian Hongbo , Wang Wei , Wan Fang , Yuan Yongbo , Lin Yun , Yang Yingguo , Zhang Xingwang , Jiang Qi , You Jingbi 
Published: October 2024

AbstractDeveloping high‐quality wide bandgap (WBG) perovskites with ≈1.7 eV bandgap (Eg) is critical to couple with silicon and create efficient silicon/perovskite tandem devices. The sufferings of large open‐circuit voltage (VOC) loss and unstable power output under operation continuously highlight the criticality to fully develop high‐quality WBG perovskite films. In this study, rubidium and thiocyanate as additive regulators in WBG perovskites are incorporated, significantly reducing non‐radiative recombination, ion‐migration, and phase segregation. The optimized 1.66 eV Eg perovskite solar cells achieved state‐of‐art 1.3 V VOC (0.36 V deficit), and delivered a stabilized power conversion efficiency of 24.3%, along with good device stability (20% degradation (T80) after over 994 h of operation under 1 sun at ≈65°C). When integrated with a flat front side silicon cell, silicon/perovskite two‐terminal tandem device (30% efficient) is obtained with a 1.97 V VOC, and T90 operational lifetime of more than 600 h at room temperature.
4.6 V Moisture‐Tolerant Electrolytes for Lithium‐Ion Batteries
Authors: Zhang Nan , Li Ai‐Min , Zhang Weiran , Wang Zeyi , Liu Yijie , Zhang Xiyue , Cai Guorui , Wan Hongli , Xu Jijian , Wang Chunsheng 
Published: October 2024

AbstractCommercial LiPF6‐based electrolytes face limitations in oxidation stability (4.2 V) and water tolerance (10 ppm). While replacing LiPF6 with lithium bis(trifluoromethane)sulfonimide (LiTFSI) improves water tolerance, it induces Al current collector corrosion above 3.7 V vs. Li/Li+. To address this, lithium cyano(trifluoromethanesulfonyl)imide (LiCTFSI) is proposed here as a non‐corrosive, moisture‐tolerant alternative. The 2.0 M LiCTFSI/propylene carbonate (PC)‐fluoroethylene carbonate (FEC) (7:3 by volume) electrolyte enables LiNi0.8Co0.1Mn0.1O2 (NCM811) cathodes to reach 210 mAh g−1 (2.8‐4.6 V) with a cycle life of 500. Full cells with NCM811||graphite (2.0 mAh cm−2) show 77.8% capacity retention after 500 cycles. Even with 2000 ppm moisture in the electrolyte, full cells maintain high cycling stability, reducing the need for costly dry rooms. The electrolyte’s low freezing point and high thermal stability enable the operation from ‐20 °C to 60 °C, delivering 168 mAh g−1 at ‐20 °C and retaining 94% capacity after 100 cycles at 60 °C. In contrast, cells with commercial LiPF6 electrolyte deliver 71 mAh g−1 at ‐20°C and retain 52.7% after 100 cycles at 60 °C. This novel salt offers a cost‐effective solution for developing robust, high‐performance batteries suitable for extreme conditions.
High‐Entropy Layered Oxide Cathode Materials with Moderated Interlayer Spacing and Enhanced Kinetics for Sodium‐Ion Batteries
Authors: Huang Zefu , Wang Shijian , Guo Xin , Marlton Frederick , Fan Yameng , Pang Wei‐Kong , Huang Tao , Xiao Jun , Li Dongfang , Liu Hao , Gu Qinfen , Yang Cheng‐Chieh , Dong Chung‐Li , Sun Bing , Wang Guoxiu 
Published: October 2024

AbstractSodium‐ion batteries (SIBs) with low cost and environmentally friendly features have recently attracted significant attention for renewable energy storage. Sodium layer oxides stand out as a type of promising cathode material for SIBs owing to their high capacity, good rate performance, and high compatibility for manufacturing. However, the poor cycling stability of layer oxide cathodes due to structure distortion greatly impacts their practical applications. Herein, a high entropy doped Cu, Fe, and Mn‐based layered oxide (HE‐CFMO), Na0.95Li0.05Mg0.05Cu0.20Fe0.22Mn0.35Ti0.13O2 for high‐performance SIBs, is designed. The HE‐CFMO cathode possesses high‐entropy transition metal (TM) layers with a homogeneous stress distribution, providing a moderated interlayer spacing to maintain the structure stability and enhance Na+ ion diffusion. In addition, Li doping in TM layers increases the Mn valence state, which effectively suppresses John–Teller effect, thus stabilizing the layered structure during cycling. Furthermore, the use of nontoxic and low‐cost raw materials benefits future commercialization and reduces the risk of environmental pollution. As a result, the HE‐CFMO cathode exhibits a super cycling performance with a 95% capacity retention after 300 cycles. This work provides a promising strategy to improve the structure stability and reaction kinetics of cathode materials for SIBs.
Low Thermal Resistance of Diamond‐AlGaN Interfaces Achieved Using Carbide Interlayers
Authors: Aller Henry T. , Pfeifer Thomas W. , Mamun Abdullah , Huynh Kenny , Tadjer Marko , Feygelson Tatyana , Hobart Karl , Anderson Travis , Pate Bradford , Jacobs Alan , Lundh James Spencer , Goorsky Mark , Khan Asif , Hopkins Patrick , Graham Samuel 
Published: October 2024

AbstractThis study investigates thermal transport across nanocrystalline diamond/AlGaN (aluminum gallium nitride) interfaces, crucial for enhancing thermal management in AlGaN‐based electronic devices. Chemical vapor deposition growth of diamond directly on AlGaN resulted in a disordered interface with a high thermal boundary resistance (TBR) of 20.6 m2‐KGW−1. Sputtered carbide interlayers of boron carbide (B4C), silicon carbide (SiC), and a mixture of boron carbide and silicon carbide (B4C/SiC) are employed to reduce thermal boundary resistance in diamond/AlGaN interfaces. The carbide interlayers resulted in record‐low thermal boundary resistance values of 3.4 and 3.7 m2‐KGW−1 for Al0.65Ga0.35N samples with B4C and SiC interlayers, respectively. STEM imaging of the interface reveals interlayer thicknesses between 1.7 and 2.5 nm, with an amorphous structure. Additionally, Fast‐Fourier Transform (FFT) characterization of sections of the STEM images displayed sharp crystalline fringes in the AlGaN layer, confirming it is properly protected from damage from hydrogen plasma during the diamond growth. In order to accurately measure the thermal boundary resistance we develop a hybrid technique, combining time‐domain thermoreflectance and steady‐state thermoreflectance fitting, offering superior sensitivity to buried thermal resistances. The findings underscore the efficacy of interlayer engineering in enhancing thermal transport and demonstrate the importance of innovative measurement techniques in accurately characterizing complex thermal interfaces. This study provides a foundation for future research in improving thermal properties of semiconductor devices through interface engineering and advanced measurement methodologies.
Improved Conductivity of Low‐Temperature‐Synthesized Graphene/Cu for CMOS Backend‐of‐Line Interconnect Applications
Authors: Wang Peng‐Chi , Shih Yi‐Hsiang , Tseng Chih‐Yuan , Liu Yu‐Jin , Huang Yao‐Hung , Lin Chrong‐Jung , King Ya‐Chin , Tu Wei‐Chen 
Published: October 2024

AbstractThis study proposes a synthesis strategy of high‐quality graphene films on the copper foil at a temperature of 400 °C throughout the graphene growth process without employing high‐temperature annealing. Through continuous CO2 laser pretreatment of the copper foil, the surface smoothness improves, and the removal of copper particles and copper oxide results in fewer defects on the foil. Therefore, the nucleation density of graphene is reduced, leading to a more uniform and continuous graphene film and showing an outstanding quality of graphene with low defects and low resistivity compared with other groups. After laser treatment, the copper foil's resistivity decreases from 1.71 ×10−8 to 1.51 ×10−8 Ω·m. The graphene‐coated on laser‐treated foil experiences an even more substantial decrease in resistivity, from 1.34 ×10−8 to 1.18 ×10−8 Ω·m, marking a significant 11.94% reduction. Excitingly, the groundbreaking technique is taken to the next level by applying it to fine copper interconnects as narrow as 0.4 µm. The experiments confirm the successful cultivation of graphene on these miniature scales, showing the immense potential of the approach. The proposed approach aligns with the demands of contemporary CMOS backend‐of‐line processes, facilitating the seamless incorporation of graphene in advanced chip technologies.
Copper‐Catalyzed Dearomative Cyclization of Indolyl Ynamides for Synthesis of Pentacyclic Spiroindolines
Authors: Xu Miao , Jiang Jia‐Tian , Dong Hao‐Xuan , Wang Guang‐Hui , Zhou Bo , Ye Long‐Wu 
Published: October 2024

AbstractThe dearomatization of indoles with ynamides is a convenient access towards polycyclic spiroindolines, which can be initiated by α‐ and β‐additions of ynamides. Currently, the related β‐addition initiated dearomative cyclization requires noble‐metal catalyst or stoichiometric oxidant. Herein, we report a copper‐catalyzed dearomative cyclization of aryl‐substituted indolyl ynamides through regioselective β‐addition onto ynamides, providing pentacyclic spiroindolines in 81–97% yields with >25:1 diastereoselectivities. Moreover, preliminary success has been obtained for the catalytic enantioselective dearomative cyclization.
Three‐Dimensional VTe2/MXene/CNT Ternary Architectures for the Development of High Performance Microsupercapacitors
Authors: Radhakrishnan Sithara , Monisha Mohan , KA Sree Raj , Saxena Manav , Jeong Sang Mun , Rout Chandra Sekhar 
Published: October 2024

AbstractRapid advancements in portable electronics have created a demand for ultrathin power sources. Microsupercapacitors (MSCs) are becoming a competitive and advantageous option for these applications. It is widely recognized that to develop MSCs with exceptional performance, electrode materials having two‐dimensonal (2D) permeable channels, structural scaffolds with high‐conductivity and large surface area are suitable. Vanadium ditelluride (VTe2) stands out as an ideal material platform in this context. Its unique combination of metallic properties and exfoliative characteristics‐stemming from the conducting Te–V–Te layers held together by weak van der Waals interlayer interactions‐ renders it highly promising for high‐performance MSCs. This study is the first to report that the restacking issues and electrochemical performance of VTe2 can be successfully avoided by the simultaneous incorporation of MXene and CNT to form a ternary hybrid. Here, a laser‐induced graphene (LIG)‐based MSC utilizing VTe2/MXene/CNT as the active electrode material is fabricated. This MSC achieve fabrications an outstanding maximum energy density of 6.84 µWh cm−2 and a power density of 304.7 µW cm−2. This significant achievement demonstrates the potential of this LIG‐based MSC to advance the design of high‐performance micro‐energy storage devices.
Nanoarchitectonics of Nickel Nitride‐V2CTX Mxene: An Efficient Bifunctional Catalyst for Alkaline Water/Seawater Applications
Authors: Deepak Deepak , Singh Tanuja , Mahapatra Abhinav , Panghal Abhishek , Nagesh Chaitanya , Roy Susanta Sinha 
Published: October 2024

AbstractSeawater, being the most plentiful natural water source worldwide, is a highly abundant and cost‐efficient medium for producing hydrogen by alkaline water electrolysis. However, the advancement of seawater electrolysis is hindered by notable impediments caused by chloride corrosion at the anode and the simultaneous chlorine evolution process. Only a limited number of non‐noble electrocatalysts demonstrate noteworthy bifunctional catalytic efficacy and long‐term durability. In this regard, Nickel Nitride tailored V2CTX Mxene nanostructures is reported as a bifunctional catalyst for overall water/seawater applications. The optimized sample Ni3N@3000‐V2CTx exhibits low overpotential values of 90 and 300 mV in acidic and alkaline + seawater solutions respectively at 10 mA cm−2 for hydrogen evolution reaction. Similarly, this catalyst shows 70 and 240 mV overpotential values in alkaline water and alkaline + seawater solutions respectively at the same current density for oxygen evolution reaction. Synergetic effects of Multiple Vanadium and Nickel valency along with compelling nitrogen bonds creates elevated density of exposed functional sites for electrocatalytic activity. Furthermore, the notable electrochemical active surface area and mass activity suggest an enhanced and significant presence of abundant active sites. Additionally, the high stability and significantly decreased charge transfer resistance expedited the overall water/seawater‐splitting reaction rate.
New Insights Into TRMT10A Syndrome: Case Report and Literature Review
Authors: Ceraolo Graziana , Spoto Giulia , Butera Ambra , Spanò Maria , Vinci Mirella , Vitello Girolamo Aurelio , Musumeci Antonino , Calì Francesco , Nicotera Antonio Gennaro , Di Rosa Gabriella 
Published: October 2024

ABSTRACTTRMT10A is related to a syndrome characterized by early‐onset diabetes mellitus, microcephaly, epilepsy, and intellectual disability. We report a case of a patient showing spastic–ataxic paraparesis and Dandy–Walker variant associated with a causative homozygous c.421‐1G > A variant in the TRMT10A gene, affecting a canonical splicing site. This mutation disrupts the “SAM‐dependent methyltransferase TRM10‐type domain”, which is implicated in methylation and S‐adenosylmethionine metabolic biological processes, crucial for mitochondrial and glucose metabolism. The prominent neurological involvement of our patient enhances the implication of TRMT10A in the brain development, suggesting a potential association between TRMT10A variants and dominant neurological phenotypes. This case expands the clinical spectrum of TRMT10A syndrome highlighting the importance of considering this gene in the evaluation of patients with brain/cerebellar malformations and spastic–ataxic paraparesis. Further research is warranted to elucidate the underlying pathogenic mechanisms and potential therapeutic implications.
Heterogeneous Catalytic Materials for Carbon dioxide Transformation: Efficient Carboxylation Cyclization to Cyclic Carbonates and Oxazolidinones
Authors: Ma Zhongyang , Chen Peibo , Wu Chancui , Liang Ying , Pan Yingming 
Published: October 2024

AbstractThe exacerbation of environmental issues is increasingly attributed to the anthropogenic emissions of carbon dioxide (CO2). CO2 is a cost‐effective and readily available C1 source. The conversion of CO2 into value‐added organic chemicals, such as cyclic carbonate and 2‐oxazolidinone, through carboxylation cyclization reactions shows promise in reducing carbon emissions and combating climate change. The use of catalysts can facilitate this process, with heterogeneous catalysts emerging as favorable due to their advantages of easy recovery and structural stability. This paper provides a comprehensive review of heterogeneous catalysts that have been utilized for the carboxylation cyclization of CO2 to afford cyclic carbonates and oxazolidinones in recent years. The catalysts include metal organic frameworks, covalent organic frameworks, super‐crosslinked polymers, conjugated microporous polymers, porous ionic organic polymers, and composite materials. We give a detailed synthesis route for each type of catalysts. Furthermore, the characteristics of the catalysts, such as BET specific surface area, CO2 adsorption capacity, and catalytic performance, is summarized and analyzed to offer insights for improving heterogeneous catalysts for CO2 conversion via carboxylation cyclization reactions in future research.
Histopathologic observations in a coccidiosis model of Eimeria tenella
Authors: Sun Zhixin , Chen Linlin , Lai Mengyu , Zhang Xixi , Li Jie , Li Zhiping , Yang Dongming , Zhao Mengyang , Wang Dongdong , Wen Pei , Gou Fengting , Dai Yuexin , Ji Yilan , Li Wen , Zhao Deming , Liu Xianyong , Yang Lifeng 
Published: October 2024

AbstractBackgroundSpecies of the genus Eimeria cause coccidiosis in chickens, resulting in a huge burden to the poultry industry worldwide. Eimeria tenella is one of the most prevalent chicken coccidia in China, and E. tenella infection causes hemorrhagic cecitis.MethodsUsing an established model of coccidiosis in chickens combined with necropsy, imaging of pathological tissue sections, and other techniques, we evaluated the gross and microscopic lesions of cecal tissue within 15 days after inoculation with sporulated oocysts and described the endogenetic developmental process and relationship between E. tenella infection and enteritis development in chickens.ResultsWe observed three generations of merogony and gamogony in E. tenella. We observed gross lesions in the cecum from 84 hpi (hours post inoculation) and microscopic lesions from 60 hpi. The lesions in the cecum mainly exhibited hemorrhagic enteritis. Their severity increased with the onset of the second generation of merogony. The lesions began to alleviate by the end of the endogenous stages of E. tenella.ConclusionWe show, for the first time, the complete observation of a series of changes in enteritis caused by 5 × 103 E. tenella oocysts. This study provides reference materials for E. tenella research and pathological diagnosis.
Brivaracetam and rufinamide combination increased seizure threshold and improved neurobehavioral deficits in corneal kindling model of epilepsy
Authors: Sattar Awais , Rehman Zohabia , Murtaza Hammad , Ashraf Waseem , Ahmad Tanveer , Alqahtani Faleh , Imran Imran 
Published: October 2024

AbstractBackgroundBesides seizures, a myriad of overlapping neuropsychiatric and cognitive comorbidities occur in patients with epilepsy, which further debilitates their quality of life. This study provides an in‐depth characterization of the impact of brivaracetam and rufinamide individually and in combination at 10 and 20 mg/kg doses, respectively, on corneal kindling‐induced generalized seizures and behavioral alterations. Furthermore, observed convulsive frequency and behavioral changes were correlated to post‐kindling‐induced changes in the activity of markers of oxidative stress.MethodsAdult C57BL/6 mice were kindled via twice‐daily transcorneal 50‐Hz electrical stimulations (3 mA) for 3 s for 12 days until animals reached a fully kindled state. After the kindling procedure, animals were tested using a set of behavioral tests, and neurochemical alterations were assessed.ResultsCorneal‐kindled animals exhibited intense generalized convulsions, altered behavioral phenotypes typified by positive symptoms (hyperlocomotion), negative symptoms (anxiety and anhedonia), and deficits in semantic and working memory. BRV 10 + RFM 20 dual regime increased convulsive threshold and propensity toward the start of stage 4–5 seizures and improved phenotypical deficits, that is, anxiety, depression, and memory impairments. Moreover, this combination therapy mitigated kindling‐induced redox impairments as evidenced by reduced malondialdehyde and acetylcholinesterase levels and increased glutathione antioxidant activity in the brain of animals subjected to repetitive brain insult.ConclusionBased on our outcomes, this dual therapy provides supporting evidence in alleviating epilepsy‐induced neurobehavioral comorbidities and changes in redox homeostasis.