bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are aromatase inhibitors in boys with predicted short stature and/or rapidly advancing bone age effective and safe?
Authors: Ferris Jessica A. , Geffner Mitchell E. 
Published: February 2017

AbstractBackground:The aim of this study was to assess aromatase inhibitor (AI) efficacy in increasing predicted adult height (PAH) and to describe clinical and biochemical safety profiles of AI-treated boys.Methods:A retrospective chart review was conducted at an academic children’s hospital endocrinology clinic. Twenty-one boys with predicted short stature and/or rapidly advancing bone age, divided as Tanner stage (TS) I–III Group 1 (G1, n=9) and TS IV–V Group 2 (G2, n=12), were treated with AIs, either letrozole or anastrozole (mean duration, G1: 2.4 years and G2: 0.9 years). Primary outcomes included PAH, hormonal/biochemical analytes, and clinical data.Results:PAH did not significantly change in either group. Mean peak testosterone significantly increased from baseline to 650±458 ng/dL (p=0.008) in G1 and to 1156±302 ng/dL (p=0.002) in G2. Estradiol did not significantly change in either group. Compared to baseline, G2 showed increased mean FSH (p=0.002), LH (p=0.002), hematocrit (p=0.0001), body mass index (BMI) z-score (p=0.0005), and acne (p=0.01).Conclusions:AIs did not increase PAH, regardless of TS. Boys in late puberty had significant increases in testosterone, gonadotropins, hematocrit, acne, and BMI, but no reduction in estradiol. The potential consequences of these findings are concerning and require long-term study, especially if AIs are started in late puberty.
Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep
Authors: Chen Audrey , Singh Chanpreet , Oikonomou Grigorios , Prober David A. 
Published: February 2017

AbstractPharmacological studies in mammals and zebrafish suggest that histamine plays an important role in promoting arousal. However, genetic studies using rodents with disrupted histamine synthesis or signaling have revealed only subtle or no sleep/wake phenotypes. Studies of histamine function in mammalian arousal are complicated by its production in cells of the immune system and its roles in humoral and cellular immunity, which can have profound effects on sleep/wake states. To avoid this potential confound, we used genetics to explore the role of histamine in regulating sleep in zebrafish, a diurnal vertebrate in which histamine production is restricted to neurons in the brain. Similar to rodent genetic studies, we found that zebrafish that lack histamine due to mutation of histidine decarboxylase (hdc) exhibit largely normal sleep/wake behaviors. Zebrafish containing predicted null mutations in several histamine receptors also lack robust sleep/wake phenotypes, although we are unable to verify that these mutants are completely nonfunctional. Consistent with some rodent studies, we found that arousal induced by overexpression of the neuropeptide hypocretin (Hcrt) or by stimulation ofhcrt-expressing neurons is not blocked inhdcorhrh1mutants. We also found that the number ofhcrt-expressing or histaminergic neurons is unaffected in animals that lack histamine or Hcrt signaling, respectively. Thus, while acute pharmacological manipulation of histamine signaling has been shown to have profound effects on zebrafish and mammalian sleep, our results suggest that chronic loss of histamine signaling due to genetic mutations has only subtle effects on sleep in zebrafish, similar to rodents.
Ocular involvement of multicentric malignant B-cell lymphoma in a ewe
Authors: Thaller Denise , Krametter-Froetscher Reinhild , Rushton James 
Published: February 2017

SummaryAn 8.5-year-old, 98 kg female mountain sheep presented with bilateral exophthalmos with reduced retropulsion of the globes, impairing physiologic eyelid closure, sanguineous ocular discharge, as well as swelling of the eyelids and periocular skin. Bilateral vitreal hemorrhage hindering examination of the fundus was further noticed. Systemic signs included reduced general demeanour, presence of a firm mass in the left half of the mammary gland, multiple masses in the area of the vulva and a mass between the shoulder blades. Complete diagnostic work-up, i. e. complete blood count, blood chemistry and coagulation status, fine needle aspiration of periocular swellings and incisional biopsy of the vulvar masses revealed a diagnosis of malignant B-cell lymphoma. Due to the deterioration in general demeanour and rapid progression of exophthalmos, resulting in bilateral corneal ulceration, despite symptomatic medical treatment, the ewe was humanely euthanized. Gross necropsy and histopathology of select tissue samples confirmed the diagnosis of multicentric malignant B-cell lymphoma. To the authors’ knowledge, this is the first report of multicentric malignant B-cell lymphoma involving the ocular adnexa in sheep.
Modelo constitucional de la fuerza pública en Colombia
Authors: Vásquez Hincapié Daniel José , Gil-García Luz Marina 
Published: February 2017

<p>La fuerza pública forma parte de la estructura constitucional del Estado. Este artículo pretende abordar el modelo constitucional de esta organización pública a partir de su caracterización general y particular; para el efecto, se revisaron, describieron y analizaron las normas constitucionales y legales que la rigen, así como la jurisprudencia relevante de la Corte Constitucional en la materia. Como resultados, se evidenciaron las semejanzas y diferencias entre las fuerzas militares y la Policía Nacional, los umbrales fácticos y jurídicos que traslapan, las tareas misionales relacionadas con el uso de la fuerza y las medidas jurídicas, administrativas y jurisprudenciales, tendientes a preservar el modelo constitucional de esta organización pública. La investigación permite concluir que el constituyente modeló la fuerza pública y en especial su misión, como instrumento para cumplir los fines del Estado y, principalmente, para mantener el orden constitucional y proteger y garantizar los derechos y libertades de todos los residentes en Colombia. </p>
Diagnóstico de componentes bioéticos en el ámbito educativo de Ciencias Biológicas y de la Salud
Authors: Contreras Islas David Sebastian , Kerbel Lifshitz Carlos , Mendieta Márquez Enrique , Pérez Hernández Marco Aurelio 
Published: February 2017

<p>Las múltiples crisis ecológico-sociales de la actualidad necesitan que la bioética global se integre a la educación superior en Ciencias Biológicas y de la Salud. Partiendo de esta premisa y con miras a desarrollar estrategias educativas que fortalezcan la adquisición de actitudes bioéticas entre los alumnos de las licenciaturas de la Divi- sión de Ciencias Biológicas y de la Salud (dcbs) de la Universidad Autónoma Metropolitana, Iztapalapa (uam-I), nuestro equipo realizó dos estudios entre 2012 y 2014, con el objetivo de conocer el contenido de bioética en planes y programas de las licenciaturas de la dcbs y las actitudes de los alumnos de licenciatura, para los cuales se emplearon una metodología de análisis de coincidencias con palabras clave y un cuestionario tipo <em>Likert</em>. Los resultados sugieren que la bioética no se ha incluido adecuadamente en el contenido de planes y programas, ni ha jugado un papel importante en la formación de las actitudes de los estudiantes que; sin embargo, no son tan desfavorables al respecto. Con base en lo anterior, los autores sugerimos una serie de estrategias educativas que podrían mejorar dicha situación, así como otro tipo de análisis para profundizar en el conocimiento de esta problemática.</p><p><strong> </strong></p>
Breeding of Sand Goby, Oxyeleotris marmorata (Blkr'), Broodstock in Earthen and Concrete Pond
Authors: Sumawidjaja Kusman , Effendi Irzal , Enywati . 
Published: February 2017

<p>ABSTRACT</p><p>Anexperiment to asses breeding performance of sand goby was conducted in earthen and concrete pond. Broodstock (125 - 500 g per fish) of similar levels at maturing were fed trash fish 7% of biomass everyday. In the rainy season, sand goby, <em>Oxyeleotris marmorata </em>(Blkr.), spawned 31 and 30 times per month producing an average of 38.300 and 36.855 eggs per nest, respectively. In the dry sesason, howeve only fish in earthen ond bred 36 times per month with an average of 39.170 eggs per nest.</p><p>Key words : breeding, sand goby fish, <em>Oxyeleotris marmorata</em></p><p> </p><p>ABSTRAK</p><p>Percobaan ini bertujuan untuk mengetahui pemijahan ikan betutu di kolain tanah dan kolarn beton. Ikan betutu (125 - 500 g per ekor) dipelihara selarna musim hujan dan musim kemarau dan diberi makan ikan teri sebanyak 7% setiap hari. Pada musim penghujan, pada kolam tanah dan kolam beton terjadi masingmasing 31 dan 30 kali pemijahan ikan betutu, <em>Oxyeleotris marmorata </em>(Blkr.), per sarang. Pada musim kemarau, hanya ikan betutu yang di kolam tanah saja yang memijah sebanyak 36 kali dengan rata-rata 39.170 butir per tahun per sarang.</p>Kata kunci : pemijahan, ikan betutu, <em>Oxyeleotris marmorata</em>
Gonad Maturation of Clown Loach (Botia macracanthus) in Pond
Authors: Effendi Irzal , Prasetya T. , Sudrajat Agus Oman , Suhenda N. , Sumawidjaja K. 
Published: February 2017

<p>The objective of this research is to know the gonad maturation of clown loach <em>{Botia macracanthus) </em>reared in pond. Two groups contain 4 female broodstock; I) carried and II) non-carried egg broodstock were reared in two separated hapas which placed in pond. Each hapa was also stocked nine males. The fish were fed pellet (32,33% protein) 10% biomass, daily in three times. After 20 days, the broodstocks were implanted by LHRH-a 100 u.g/kg of body weight. In the group I, diameter of egg in gonad were developed from 1,028 mm at the beginning of implantation to 1,071 and 1,106 mm at day of 15 and 30 after implantation respectively. In the group II, only one female has developed her gonad successfully. The egg was developed to 0,937 and 1,026 mm after 15 and 30 day implantation respectively.</p> <p>Key words : Gonad maturation, clown loach, <em>Botia macracanthus, </em>pond</p> <p> </p> <p>ABSTRAK</p> <p>Penelitian ini bertujuan untuk mengetahui pematangan gonad induk ikan botia <em>(Botia macracanthus) </em>yang dipelihara di kolam. Dua kelompok induk betina; I) sudah mengandung telur dan II) belum mengandung telur masing-masing sebanyak 4 ekor dipelihara masing-masing dalam 2 hapa. Ke dalam setiap hapa juga ditempatkan induk jantan sebanyak 9 ekor. Induk diberi pakan berupa pelet (protein, 32,33%) sebanyak 10% dari bobot biomasa per hari, 3 kali sehari, dan diberi LHRH-a dengan dosis 100 ng/kg bobot tubuh secara implantasi pada hari ke 20 pemeliharaan. Induk dalam kelompok pertama telurnya berkembang dari rata-rata 1,028 pada saat pemberian LHRH-a menjadi rata-rata 1,071 dan 1,106 mm masing-masing pada hari ke 15 dan 30 setelah pemberian. Pada kelompok kedua hanya satu ekor induk yang berkembang gonadnya setelah diberi LHRH-a. telur induk ikan tersebut berkembang dari 0,937 menjadi 1,026 mm masing pada hari ke 15 dan 30 setelah implantasi.</p> Kata kunci : Pematangan gonad, ikan botia, <em>Botia macracanthus, </em>kolam
Phytobiotic Properties of Garlic, Red Ginger, Turmeric and Kencur in Growing Ducks
Authors: Ismoyowati Ismoyowati , Indrasanti Diana , Mufti Mochamad , Farjam Abdoreza Soleimani 
Published: February 2017

Abstract. Phytobiotic properties of garlic (Allium sativum), turmeric (Curcuma domestica), red ginger (Zingiber officinale) and kencur (Kaempferia galangal) were studied using standard in vitro antibacterial test and in vivo feeding trial with ducklings. In the in vitro experiment, potency of aqueous extract of these phytobiotic agents were tested against Salmonella pullorum and Escherichia coli. Feeding trial was carried out for 6 week starting at day 28 using ducklings fed diets supplemented with 1% of each of four phytobiotic agents. The highest antibacterial activity against S. pullorum and E. coli was observed with garlic and no additive effect when mixture of phytobiotics was used. Weight gain, fed intake and feed conversion ratio of ducklings were not affected by inclusion of garlic, red ginger and kencur. However, 1% turmeric supplementation significantly reduced growth performance to ducklings. Key words: phytobiotic, antibiotic, duck, medicinal plants Abstrak. Penelitian karakteristik fitobiotik dari bawang putih (Allium sativum), kunyit (Curcuma domestica), jahe merah (Zingiber officinale) dan kencur (Kaempferia galangal) telah dilakukan secara in vitro melalui uji aktivitas antibakteri dan secara in vivo dengan perlakuan suplemetasi fitobiotik didalam pakan anak itik. Pada percobaan in vitro, potensi aktivitas antibakteri dari ektrak fitobiotik diuji menggunakan Salmonella pullorum and Escherichia coli. Percobaan suplementasi fitobiotik diberikan masing-masing sebesar 1% didalam pakan anak itik. Pemberian pakan perlakuan dilakukan selama 6 minggu, dimulai pada saat anak itik berumur 28 hari. Hasil penelitian menunjukkan aktivitas antibakteri terhadap S. pullorum dan E. coli paling tinggi adalah ektrak bawang putih dan tidak ada pengaruh yang lebih baik apabila dicampur dengan ektrak fitobiotik lainnya. Pertambahan bobot badan, konsumsi pakan dan konversi pakan anak itik tidak dipengaruhi oleh penambahan bawang putih, kunyit, jahe merah dan kencur. Akan tetapi, suplementasi kunyit nyata menurunkan performan pertumbuhan anak itik. Kata kunci: fitobiotik, antibiotik, itik, tanaman obat-obatan.
Supplementation of Vitamin E and C in the Feed to Meat Quality of Muscovy Ducks Stored in a Temperature Chamber, Refrigerator and Freezer
Authors: Tugiyanti Elly , Yuwanta Tri , Zuprizal Zuprizal , Rusman Rusman , Ismoyowati Ismoyowati 
Published: February 2017

Research has been conducted to determine the effectiveness of antioxidant supplementation of vitamin E and C in the feed to meat quality of the Muscovy duck meat stored at room temperature, refrigerator and freezer. Eighty-four Muscovy duck tail males aged 9 weeks maintained for 5 weeks and allocated into 7 treatments with 4 replications and each replication consisted of Muscovy duck 3 heads. Completely Randomized Design was applied, in the which treatments were vitamin E and vitamin C supplementation to the basal feed containing 21% protein and 3100 kcal / kg administered metabolic energy into seven groups namely E0C0: basal feed without Vit E and Vit C, E400: basal feed plus 400 IU of vitamin E, E600: basal feed plus 600 IU of vitamin E, C400: basal feed plus 400 mg / kg feed vitamin C, C600: basal feed plus 600 mg / kg feed as much vitamin C, E200C200: basal feed plus 200 IU vitamin E and 200 mg / kg feed vitamin C, and E300C300: basal feed plus 300 IU of vitamin E and 300 mg / kg feed of vitamin C. The parameters measured were the color of meat that includes the value of L * (lightness), a * (Redness) and b * (yellowness), tenderness and cooking looses. The data obtained and the analysis of variance followed honestly significant difference test.Muscovy duck meat that vitamin E-supplemented feed brightness levels did not differ (P> 0.05) with non-supplemented, otherwise Muscovy duck meat that feed supplemented vitamin C or a combination of vitamin E and C levels of brightness up to 3 days either at room temperature or stored the refrigerator is still high. Supplementation of vitamin E and C was highly significant (P <0.01) against redness (a*) meat stored in different storage means. Muscovy duck meat that feed not supplemented vitamin E and C redness (a*) did not differ (P> 0.05) between the age of 0 hours with that stored in the refrigerator or freezer. B * value of Muscovy duck meat that feed not given vitamin E and C as well as different combinations (P <0.05) with Muscovy duck meat that feed supplemented with vitamin C or a combination of vitamins E and C. The Muscovy duck meat that feed supplemented vitamin E, C or a combination of vitamins E and C if stored at room temperature or refrigerator up to 3 days the value of L* and a* is still high, but the b * low.
Reproductive Performance of Various Breeds of Sentul Chicken
Authors: Mugiyono Sigit , Saleh Dadang Mulyadi , Sukardi Sukardi 
Published: February 2017

This study was conducted to determine the reproductive performance of various breeds of Sentul chicken. The present research was assigned in an experimental model with a completely randomized design (CRD), with 5 breeds of Sentul chicken were created as treatments, namely Abu Sentul chicken = SA; Batu Sentul Chicken=SB; Emas Sentul Chicken=SE; Debu Sentul Chicken=SD; and Geni Sentul Chicken=SG. Each treatment was repeated 5 times with 4 females and 1 male birds each, thus the total number of chickens were 100 females and 25 males with an average initial female weight was 1,336.05 ± 84,99 g and male weight was 2,050.53 ± 121,78 g. The experiment was conducted for 14 weeks started from 20 week old until 34 week old. Variables measured were spermatozoa production, fertility, and hatchability. Data were subjected to analysis of variance and HSD test. Results showed that various breeds of Sentul chicken had no significant effect (P>0.05) on spermatozoa production, and had significant effect (P<0.05) on fertility and hatchability. It can be concluded that spermatozoa production of various breeds of Sentul chicken are relatively similar, while fertility and hatchability of Emas chicken was lower than that of Abu Sentul chicken and Batu Sentul Chicken.
Raw Semen Characteristics of Three Different Indonesian Local Roosters
Authors: Hambu Emilia Kamung , Arifiantini Raden Iis , Purwantara Bambang , Darwati Sri 
Published: February 2017

Indonesia has agreat variety of roosters, either indigenous type as well as exotic and cross breed. The purpose of this experiment was to study the characteristics of semen from three types of Indonesian local roosters such as Merawang, Kampung and crosses Sentul Kampung with Kedu (SK Kedu). A total of 15 roosters consist of Merawang roosters, Kampung, and SK Kedu roosters were 5 each. The semen was collected 3 times a week by dorso-abdominal and cloaca massage method. The parameters evaluation was macroscopic characteristics consist of volume, color, consistency, and pH. Microscopic evaluation of semen such as a mass movement, sperm motility, live sperm, sperm abnormality and sperm concentration. Results of this experiment showed that semen volume of Merawang (0.40±0.26 mL) was higher (p<0.05) compare to Kampung (0.24±0.12 mL) or SK Kedu (0.16±0.10 mL) but no difference on semen color, consistency and semen pH. There were no difference in the mass movement, sperm motility and live sperm as well as on sperm abnormality among three types of roosters. Sperm concentration of Merawang (4490 million mL-1) was significantly higher than Kampung (3245 million mL-1) and the SK Kedu roosters (3751 million mL-1). Its was conclude that Merawang roosters had good semen quality better than Kampung and SK Kedu roosters
ISOLASI DAN IDENTIFIKASI SENYAWA KIMIA SERTA UJI AKTIVITAS ANTICANDIDAISIS SERBUK DAUN SIRIH DUDUK (Piper sarmentosum Roxb. Ex Hunter)
Authors: Suwandri Suwandri , Diastuti Hartiwi 
Published: February 2017

Sirih duduk or Piper sarmentosum Roxb. ex Hunter have been long used the people in Indonesia for traditional medicine to cure various diseases. One of them was used to treat fungoid diseases. This research was aimed to examine the anticandidaisis activity from extract of P. sarmentosum leaves and to isolate and identify the anticandidaisis compounds from P. sarmentosum leaves. The isolation bioactive compounds of P. sarmentosumleaves was performed by extraction the powder of P. sarmentosum leaves using methanol and the bioactivity tests were performed against Candida albicans. The methanol extracts was then fractionated using organic solvents such as n-hexane, benzene, chloroform, and ethyl acetate. Identification of the bioactive compounds was carried out using ultraviolet-visible spectrometry, fourier transform infra red spectrometry and gas chromatography-mass spectrometry. The result showed that the chloroform fraction of methanol extract of P. sarmentosum leaves have activity against C. albicans. The fractionation was performed by coloumn chromatography using n-hexane-ethyl acetate(1:1) eluent. A bioactive compound of sinamic acid derivative was 4-ethoxy-2-hidroxy-3,5-dimethoxy sinamic acid could be purely isolated.
SINTESIS NATRIUM PENTAGAMAVUNONAT DAN UJI STABILITASNYA MENGGUNAKAN SPEKTROFOTOMETER UV-Visible
Authors: Setiawan Ely , Trisnowati Trisnowati , Hermawan Dadan 
Published: February 2017

A research on the synthesis of sodium pentagamavunonat (Na-PGV-0) and its stability test using UV-Visible spectrophotometer were carried out. The synthesis of Na-PGV-0 carried out by reacting PGV-0 in tetrahydrofuran solvent refluxed with sodium ethoxide in mol comparison (1:2) for two hours. Structure elucidation by spectroscopic methods using UV-Visible, IR, 1H-NMR, 13C-NMR and stability test in water using UV-Visible spectrophotometer. The reaction yields 107,21 % (% w/w) products. A products was soluble in water and methanol. Structure elucidation results indicated that the formed compound where the OH phenolic of pentagamavunon-0 was replaced by sodium ions. Stability test shows that decreasing of sodium
UJI AKTIFITAS ANTIKANKER EKSTRAK ETANOL KULIT BATANG Bruguiera gymnorhiza TERHADAP SEL MEYLOMA
Authors: Warsinah Warsinah , Lestari Puji , Trisnowati Trisnowati 
Published: February 2017

Mangrove vegetation especially tanjang (Bruguiera gymnorhiza) known as a kind of plant that used as an ingredients for traditional medicine. Bioactive compound in tanjang bark has potential medical. Although there is no previous experiment about tanjang bark, few compounds from Bruguiera genus has been experimented and has an activity as an anti-cancer and anti-tumor. The purpose of this experiment is to conduct sitotoxicity tanjang bark against Meyloma cell. Tanjang bark sample that used obtained from Tritih beach at Cilacap. Tanjang bark that has been cleaned and dried is cut and then crused until it obtain powder. The powder is been maceration with 96% ethanol and been evaporation. The extract that obtain is used in sitotoxicity test using MTT (3-(4,5-dimethylthiazoil-2-il)-2,5-diphenil tetrazolium bromide) method toward Meyloma cell after 24 hour of incubation using several concentration variation. Tanjang bark extract in ethanol has LC50 value 508.19 mg/ml. Morphology analyze and nuclear staining shows that there is apoptosis activity even in small amount. The result shows that tanjang bark extract has a potency as an anti-cancer toward Meyloma cell.
PREPARASI DAN KARAKTERISASI KOMPLEKS KITOSAN HIDROGEL-TEMBAGA(II)
Authors: Mohadi Risfidian , Hidayati Nurlisa , N.R Melany 
Published: February 2017

Research about preparation and characterization complex of chitosan hydrogel–copper(II) had been done. Chitosan hydrogel was obtained from deacetylation of chitin which was isolated from crab shells. Characterization included determination of N-total, Corganic , deacetylation degree, and FTIR spectroscopy. The results of research showed that obtained chitosan had 7,9571% N-total, 2,767% Corganic, and 71,486% deacetylation degree. FTIR spectrum of chitosan showed the increasing in percentage of transmitant from C=O group and the shifting in wavenumber from 1561,5 to 1563 cm-1 indicated N-H bending. Generally, FTIR spectrum of chitosan hydrogel showed the shifting to higher wavenumbers caused by changing in bond angles of chitosan group. FTIR spectrum of chitosan hydrogel-copper(II) complex showed that absorption regions of N-H group becoming wide and the shifting in wavenumber from 1594,74 to 1542,9 cm-1 whichindicated N-H bending because of copper(II) bonding to N-group of chitosan.