bluuebunny/crossref_metadata_2025_split huggingface dataset:
SARS-CoV-2 anti-N antibodies among healthcare personnel without previous known COVID-19
Authors: Tiwary Sajal , O’Neil Caroline A. , Peacock Kate , Cass Candice , Amor Mostafa , Wallace Meghan A. , McDonald David , Arter Olivia , Alvarado Kelly , Vogt Lucy , Stewart Henry , Park Daniel , Fraser Victoria J. , Burnham Carey-Ann D. , Farnsworth Christopher W. , Kwon Jennie H. ,   for the CDC Prevention Epicenters Program
Published: October 2024

Abstract

Objective:
To measure SARS-CoV-2 anti-nucleocapsid (anti-N) antibody seropositivity among healthcare personnel (HCP) without a history of COVID-19 and to identify HCP characteristics associated with seropositivity.

Design:
Prospective cohort study from September 22, 2020, to March 3, 2022.

Setting:
A tertiary care academic medical center.

Participants:
727 HCP without prior positive SARS-CoV-2 PCR testing were enrolled; 559 HCP successfully completed follow-up.

Methods:
At enrollment and follow-up 1–6 months later, HCP underwent SARS-CoV-2 anti-N testing and were surveyed on demographics, employment information, vaccination status, and COVID-19 symptoms and exposures.

Results:
Of 727 HCP enrolled, 27 (3.7%) had a positive SARS-CoV-2 anti-N test at enrollment. Seropositive HCPs were more likely to have a household exposure to COVID-19 in the past 30 days (OR 7.92, 95% CI 2.44–25.73), to have had an illness thought to be COVID-19 (4.31, 1.94–9.57), or to work with COVID-19 patients more than half the time (2.09, 0.94–4.77). Among 559 HCP who followed-up, 52 (9.3%) had a positive SARS-CoV-2 anti-N antibody test result. Seropositivity at follow-up was associated with community/household exposures to COVID-19 within the past 30 days (9.50, 5.02–17.96; 2.90, 1.31–6.44), having an illness thought to be COVID-19 (8.24, 4.44–15.29), and working with COVID-19 patients more than half the time (1.50, 0.80–2.78).

Conclusions:
Among HCP without prior positive SARS-CoV-2 testing, SARS-CoV-2 anti-N seropositivity was comparable to that of the general population and was associated with COVID-19 symptomatology and both occupational and non-occupational exposures to COVID-19.
Epigenetic changes in patients with post-acute COVID-19 symptoms (PACS) and long-COVID: A systematic review
Authors: Shekhar Patil Madhura , Richter Emma , Fanning Lara , Hendrix Jolien , Wyns Arne , Barrero Santiago Laura , Nijs Jo , Godderis Lode , Polli Andrea 
Published: October 2024

Abstract

Background
Up to 30% of people infected with SARS-CoV-2 report disabling symptoms 2 years after the infection. Over 100 persistent symptoms have been associated with Post-Acute COVID-19 Symptoms (PACS) and/or long-COVID, showing a significant clinical heterogeneity. To develop effective, patient-targeted treatment, a better understanding of underlying mechanisms is needed. Epigenetics has helped elucidating the pathophysiology of several health conditions and it might help unravelling inter-individual differences in patients with PACS and long-COVID. As accumulating research is exploring epigenetic mechanisms in PACS and long-COVID, we systematically summarized the available literature on the topic.

Methods
We interrogated five databases (Medline, Embase, Web of Science, Scopus and medXriv/bioXriv) and followed PRISMA and SWiM guidelines to report our results.

Results
Eight studies were included in our review. Six studies explored DNA methylation in PACS and/or long-COVID, while two studies explored miRNA expression in long-COVID associated with lung complications. Sample sizes were mostly small and study quality was low or fair. The main limitation of the included studies was a poor characterization of the patient population that made a homogeneous synthesis of the literature challenging. However, studies on DNA methylation showed that mechanisms related to the immune and the autonomic nervous system, and cell metabolism might be implicated in the pathophysiology of PACS and long-COVID.

Conclusion
Epigenetic changes might help elucidating PACS and long-COVID underlying mechanisms, aid subgrouping, and point towards tailored treatments. Preliminary evidence is promising but scarce. Biological and epigenetic research on long-COVID will benefit millions of people suffering from long-COVID and has the potential to be transferable and benefit other conditions as well, such as Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). We urge future research to employ longitudinal designs and provide a better characterization of included patients.
Comparative Analysis of Drug Shortages in the US and Germany (2016 – 2023)
Authors: Nussli Emanuel , Serra-Burriel Miquel , Vokinger Kerstin N. 
Published: October 2024

AbstractThis article analyzes trends in drug shortages in the US and Germany, the largest pharmaceutical market in Europe, between 2016 and 2023. It assesses the commonalities and differences between the countries in terms of active substances in shortage, time duration in shortage, and cyclic trends.
USPTO’s Lax Policy Leads to Humira Formulation Thicket
Authors: Chao Bernard 
Published: October 2024

AbstractBiosimilar drugs enter the United States market well after they enter the European market. That is likely because pharmaceutical companies have many more patents in the United States than in Europe. But why is patent coverage of biological drugs so much more extensive in United States? This case study seeks to answer this question for drug formulation patents.
The angular correlation function as measured by the GLEAM-X survey
Authors: Venville Brandon , Parkinson David , Hurley-Walker Natasha , Galvin Timothy James , Ross Kathryn 
Published: October 2024

Abstract
The angular correlation is a method for measuring the distribution of structure in the Universe, through the statistical properties of the angular distribution of galaxies on the sky. We measure the angular correlation of galaxies from the second data release of the GaLactic and Extragalactic All-sky Murchison Widefield Array eXtended survey (GLEAM-X) survey, a low-frequency radio survey covering declinations below

$+30^\circ$

. We find an angular distribution consistent with the

$\Lambda$

CDM cosmological model assuming the best fitting cosmological parameters from Planck Collaboration et al. (2020, A&A, 641, A6). We fit a bias function to the discrete tracers of the underlying matter distribution, finding a bias that evolves with redshift in either a linear or exponential fashion to be a better fit to the data than a constant bias. We perform a covariance analysis to obtain an estimation of the properties of the errors, by analytic, jackknife, and sample variance means. Our results are consistent with previous studies on the topic, and also the predictions of the

$\Lambda$

CDM cosmological model.
A necessary condition for breakeven in dipole-confined plasmas
Authors: Di Vita A. 
Published: October 2024

We have derived a necessary condition for the achievement of breakeven in axisymmetric plasmas with zero toroidal field and confined by a dipole magnetic field (B. Lehnert, Nature, vol. 181, 1958, p. 4605; A. Hasegawa, Comments Plasma Phys. Control. Fusion, vol. 11, no. 3, 1987). Excellent MHD stability, high values of

$\beta$

(up to

$26$

%) and good confinement properties awaken the interest of private investors after years of neglect due to lack of public funding and competing alternative lines of research like the tokamak. Starting from a requirement of self-consistency between the balances of momentum and energy in a dipole-confined, two-species plasma and assuming a Maxwellian distribution function for ions and electrons, we derive a necessary condition for breakeven. This condition is more stringent than the Lawson criterion because of the lack of a stabilizing toroidal field. For a given current flowing across the toroidal coil internal to the plasma, the crucial factor at stake is the ratio between the radius of the main toroidal coil and the radius of the vacuum chamber.
The development and applications of multidimensional biomolecular spectroscopy illustrated by photosynthetic light harvesting
Authors: Fleming Graham R. , Scholes Gregory D. 
Published: October 2024

Abstract
The parallel and synergistic developments of atomic resolution structural information, new spectroscopic methods, their underpinning formalism, and the application of sophisticated theoretical methods have led to a step function change in our understanding of photosynthetic light harvesting, the process by which photosynthetic organisms collect solar energy and supply it to their reaction centers to initiate the chemistry of photosynthesis. The new spectroscopic methods, in particular multidimensional spectroscopies, have enabled a transition from recording rates of processes to focusing on mechanism. We discuss two ultrafast spectroscopies – two-dimensional electronic spectroscopy and two-dimensional electronic-vibrational spectroscopy – and illustrate their development through the lens of photosynthetic light harvesting. Both spectroscopies provide enhanced spectral resolution and, in different ways, reveal pathways of energy flow and coherent oscillations which relate to the quantum mechanical mixing of, for example, electronic excitations (excitons) and nuclear motions. The new types of information present in these spectra provoked the application of sophisticated quantum dynamical theories to describe the temporal evolution of the spectra and provide new questions for experimental investigation. While multidimensional spectroscopies have applications in many other areas of science, we feel that the investigation of photosynthetic light harvesting has had the largest influence on the development of spectroscopic and theoretical methods for the study of quantum dynamics in biology, hence the focus of this review. We conclude with key questions for the next decade of this review.
Intergenerational transmission of depressive symptoms: Maternal socialization of infant positive affect as a mediator
Authors: Schmitt Gabrielle , Jamieson Brittany , Lim Danielle , Atkinson Leslie 
Published: October 2024

Abstract
Parenting behaviors play an important role in the transmission of depressive symptoms from mothers to children. Although reduced positive affect is a central feature of depression, models of intergenerational transmission have neglected maternal socialization of positive affect as a mediating mechanism. This study investigated whether maternal responses to infant positive affect mediate the link between mothers’ and toddlers’ depressive symptoms. A community sample of 128 mothers (58% White) and their infants (Mage = 6.65 months, SD = 0.53 at first visit) participated in 3 assessments over a 1-year period. Assessments included self-reports of postpartum depressive symptoms, observational measures of maternal responses to infant positive affect and maternal sensitivity, and mother report of toddlers’ depressive problems. Mediation analyses revealed that mothers with elevated postpartum depressive symptoms displayed fewer supportive responses to their infants’ positive affect. In turn, infants who received fewer supportive responses had more depressive problems in toddlerhood. The indirect effect of postpartum depressive symptoms on toddlers’ depressive problems via maternal supportive responses remained significant after controlling for maternal sensitivity. Findings suggest that maternal responses to infant positive affect play a unique role in the intergenerational transmission of depressive symptoms. The theoretical and practical implications of these findings are discussed.
Food acquisition and consumption by NOVA food classification and lived poverty index among rural and urban households in South Africa and Ghana
Authors: Agyapong Nana Ama Frimpomaa , Annan Reginald Adjetey , Kroll Florian , Apprey Charles , Aduku Linda Nana Esi , Aidoo Robert , Swart Elizabeth Catherina 
Published: October 2024

Abstract

Objective:
This study aimed to determine differences in food consumption by the NOVA food categories in South Africa and Ghana and how they relate to poverty and food supply systems.

Design:
This study used a cross-sectional design to assess household food acquisition and lived poverty index.

Setting:
The study was conducted in Khayelitsha and Mount Frere, urban and rural communities in South Africa, respectively, and Ahodwo and Ejuratia, urban and rural communities in Ghana, respectively.

Participant:
An adult in charge of or knowledgeable about household food acquisition and consumption was selected to participate in the study.

Results:
A total of 1299 households participated in the study. Supermarkets were a prominent source of ultra-processed foods for households in South Africa, while informal outlets were an important source of ultra-processed foods in Ghana. Consumption of unprocessed foods was higher among South African households (58·2 %) than Ghanaian households (41·8 %). In South Africa, deprivation was associated with increased odds of infrequent consumption of both unprocessed foods (OR 3·431 P < 0·001) and ultra-processed foods (OR 2·656 P < 0·001) compared with non-deprivation. In Ghana, no significant differences were observed between deprived households and non-deprived households in relation to the consumption of the NOVA food classes.

Conclusion:
Different food supply systems and poverty are associated with household acquisition of the different NOVA food classes. Policies should be geared towards formal shops in South Africa and informal shops in Ghana to reduce the consumption of key obesogenic foods.
Environmental house calls can reduce symptoms of chemical intolerance: a demonstration of personalized exposure medicine
Authors: Rincón Rodolfo , Perales Roger , Palmer Raymond F. , Forster Jackie F. , Hernandez Jessica F. , Bayles Bryan , Grimes Carl , Jaén Carlos R. , Miller Claudia S. 
Published: October 2024

Abstract

Aim:
The goals of this investigation were to 1) identify and measure exposures inside homes of individuals with chemical intolerance (CI), 2) provide guidance for reducing these exposures, and 3) determine whether our environmental house calls (EHCs) intervention could reduce both symptoms and measured levels of indoor air contaminants.

Background:
CI is an international public health and clinical concern, but few resources are available to address patients’ often disabling symptoms. Numerous studies show that levels of indoor air pollutants can be two to five (or more) times higher than outdoor levels. Fragranced consumer products, including cleaning supplies, air fresheners, and personal care products, are symptom triggers commonly reported by susceptible individuals.

Methods:
A team of professionals trained and led by a physician/industrial hygienist and a certified indoor air quality specialist conducted a series of 5 structured EHCs in 37 homes of patients reporting CI.

Results:
We report three case studies demonstrating that an appropriately structured home intervention can teach occupants how to reduce indoor air exposures and associated symptoms. Symptom improvement, documented using the Quick Environmental Exposure and Sensitivity Inventory Symptom Star, corresponded with the reduction of indoor air volatile organic compounds, most notably fragrances. These results provide a deeper dive into 3 of the 37 cases described previously in Perales et al. (2022).

Discussion:
We address the long-standing dilemma that worldwide reports of fragrance sensitivity have not previously been confirmed by human or animal challenge studies. Our ancient immune systems’ ‘first responders’, mast cells, which evolved 500 million years ago, can be sensitized by synthetic organic chemicals whose production and use have grown exponentially since World War II. We propose that these chemicals, which include now-ubiquitous fragrances, trigger mast cell degranulation and inflammatory mediator release in the olfactory-limbic tract, thus altering cerebral blood flow and impairing mood, memory, and concentration (often referred to as ‘brain fog’). The time has come to translate these research findings into clinical and public health practice.
Attributing Responsibility to Big Tech for Mass Atrocity: Social Media and Transitional Justice
Authors: Espíndola Juan 
Published: October 2024

Big Tech companies such as Meta, the owner of Facebook, are increasingly accused of enabling human rights violations. The proliferation of toxic speech in their digital platforms has been in the background of recent episodes of mass atrocity, the most salient of which recently transpired in Myanmar and Ethiopia. The involvement of Big Tech companies in mass atrocity raises multiple normative and conceptual challenges. One is to properly conceptualize Meta’s responsibility for the circulation of toxic speech. On one view, endorsed by the corporation itself, Meta can be absolved from any significant share of responsibility for these atrocities because toxic speech is the speech of some (rogue) users, hosted but neither created nor endorsed by the company; if anything, Meta is responsible for failing to anticipate and swiftly remove that speech. I will argue that this view is misleading, as it misses the underlying forces crafting toxic speech. Meta’s business model relies on what one might call the algorithmic capture of attention, which it achieves by manipulating its users and by creating an environment in which manipulative practices of some users thrive over others. This fact alone turns the company into a co-creator of toxic speech rather than a mere conduit of the toxic speech of others. As a result, it is safe to claim that Meta bears significant causal responsibility and sufficient moral responsibility for the dissemination of toxic speech, such that it justifies its inclusion in transitional justice processes and grounds its moral obligation to act in ways that advance these processes.
To what extent can oracy education and student dialogue support historical thinking skills in Year 7?
Authors: Low Kitty 
Published: October 2024

Abstract
During the course of my teacher training, I have encountered two distinct classroom contexts for oracy: a term that refers to the ability to express oneself in speech. At my first placement school, very few students were willing to answer questions or present arguments in front of their peers. Conversely, the majority of students at my second placement school are keen to demonstrate their knowledge, yet often speak over one another during discussion tasks. In both schools, dialogue is mainly directed towards the teacher; students rarely offer extended answers during lessons, and oral reasoning and argumentation generally take place as a precursor to written work. I therefore wanted to implement a sequence of lessons where the learning was intentionally carried out and measured through student talk and cooperation. In particular, I wanted to examine how far teaching specific oracy skills and providing informal scaffolded opportunities for presentational and exploratory talk can support the development of historical thinking skills in Year 7 (age 11): in other words, students' ability to consider multiple historical perspectives; to appreciate the difference between modern and ancient values; to critically engage with historical terminology, and to present and justify an argument. Students' responses were generally positive and engagement raised. I conclude with further thoughts about future practice.
Convectively Induced Secondary Circulations and Wind‐Driven Heat Fluxes in the Surface Energy Balance Over Land
Authors: Colston Seth , Williams Ian N. 
Published: October 2024

AbstractIncreased resolution has enabled kilometer‐scale weather and climate models to partially resolve secondary circulations, including horizontal convective rolls (HCRs) and cold pool gust fronts. Although these circulations are ubiquitous in convective boundary layers over land, their impacts on the surface energy balance are largely unknown. Doppler lidar and surface observations were combined with DOE E3SM land model experiments, revealing increased surface winds (5 m/s) and heat fluxes (50 W/m2) in convergent branches of HCRs. Larger wind‐driven flux responses (up to 150 W/m2) were found along gust fronts. Surface energy balance shifts to accommodate wind‐driven fluxes, reducing ground heat conduction and longwave cooling. Our findings from the US Southern Great Plains are broadly relevant to modeling convective boundary layers. In particular, widely used subgrid wind gust parameterizations were found to be physically inconsistent with resolved secondary circulations and could worsen climate prediction biases at kilometer‐scales.
A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease
Authors: Thomas Tom , Friedrich Matthias , Rich-Griffin Charlotte , Pohin Mathilde , Agarwal Devika , Pakpoor Julia , Lee Carl , Tandon Ruchi , Rendek Aniko , Aschenbrenner Dominik , Jainarayanan Ashwin , Voda Alexandru , Siu Jacqueline H. Y. , Sanches-Peres Raphael , Nee Eloise , Sathananthan Dharshan , Kotliar Dylan , Todd Peter , Kiourlappou Maria , Gartner Lisa , Ilott Nicholas , Issa Fadi , Hester Joanna , Turner Jason , Nayar Saba , Mackerodt Jonas , Zhang Fan , Jonsson Anna , Brenner Michael , Raychaudhuri Soumya , Kulicke Ruth , Ramsdell Danielle , Stransky Nicolas , Pagliarini Ray , Bielecki Piotr , Spies Noah , Marsden Brian , Taylor Stephen , Wagner Allon , Klenerman Paul , Walsh Alissa , Coles Mark , Jostins-Dean Luke , Powrie Fiona M. , Filer Andrew , Travis Simon , Uhlig Holm H. , Dendrou Calliope A. , Buckley Christopher D. 
Published: October 2024

AbstractPrecision medicine in immune-mediated inflammatory diseases (IMIDs) requires a cellular understanding of treatment response. We describe a therapeutic atlas for Crohn’s disease (CD) and ulcerative colitis (UC) following adalimumab, an anti-tumour necrosis factor (anti-TNF) treatment. We generated ~1 million single-cell transcriptomes, organised into 109 cell states, from 216 gut biopsies (41 subjects), revealing disease-specific differences. A systems biology-spatial analysis identified granuloma signatures in CD and interferon (IFN)-response signatures localising to T cell aggregates and epithelial damage in CD and UC. Pretreatment differences in epithelial and myeloid compartments were associated with remission outcomes in both diseases. Longitudinal comparisons demonstrated disease progression in nonremission: myeloid and T cell perturbations in CD and increased multi-cellular IFN signalling in UC. IFN signalling was also observed in rheumatoid arthritis (RA) synovium with a lymphoid pathotype. Our therapeutic atlas represents the largest cellular census of perturbation with the most common biologic treatment, anti-TNF, across multiple inflammatory diseases.