bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hyperspectral data acquisition and analysis in imaging and real-time active MIR backscattering spectroscopy
Authors: Jarvis Jan , Haertelt Marko , Hugger Stefan , Butschek Lorenz , Fuchs Frank , Ostendorf Ralf , Wagner Joachim , Beyerer Juergen 
Published: March 2017

Abstract
In this work we present data analysis algorithms for detection of hazardous substances in hyperspectral observations acquired using active mid-infrared (MIR) backscattering spectroscopy. We present a novel background extraction algorithm based on the adaptive target generation process proposed by Ren and Chang called the adaptive background generation process (ABGP) that generates a robust and physically meaningful set of background spectra for operation of the well-known adaptive matched subspace detection (AMSD) algorithm. It is shown that the resulting AMSD-ABGP detection algorithm competes well with other widely used detection algorithms. The method is demonstrated in measurement data obtained by two fundamentally different active MIR hyperspectral data acquisition devices. A hyperspectral image sensor applicable in static scenes takes a wavelength sequential approach to hyperspectral data acquisition, whereas a rapid wavelength-scanning single-element detector variant of the same principle uses spatial scanning to generate the hyperspectral observation. It is shown that the measurement timescale of the latter is sufficient for the application of the data analysis algorithms even in dynamic scenarios.
Regio- and stereoselective synthesis of [1,3]thiazolo[3,2-b][1,2,4]triazol-7-ium salts via electrophilic heterocyclization of 3-S-propargylthio-4Н-1,2,4-triazoles and their antimicrobial activity
Authors: Slivka Mikhailo , Korol Nataliya , Pantyo Valerij , Baumer Vjacheslav , Lendel Vasil 
Published: March 2017

Abstract
A procedure for the preparation of the title salts via regioselective halocyclization of 3-S-propargylthio-4Н-1,2,4-triazoles is reported. Stereoselectivity of electrophilic heterocyclization depends on the nature of the electrophilic reagent: bromination is better than iodobromination and iodination. The heterocyclization with tellurium tetrahalogenides leads to the formation of a mixture of geometric isomers of the salts. Their structure was confirmed by 1H NMR, 13C NMR, НМВС and single crystal X-ray diffraction analysis.
13C NMR spectroscopy of heterocycles: 1-phenyl-3-aryl/t-butyl-5-arylpyrazoles
Authors: Hockstedler Amy N. , Edjah Beatrice A. , Azhar Saajid Z. , Mendoza Hadrian , Brown Nicole A. , Arrowood Hayley B. , Clay Andrew C. , Shah Anand B. , Duffek Glenda M. , Cui Jianmei , Baumstark Alfons L. 
Published: March 2017

Abstract
A series of chalcones 1–12 were converted to pyrazolines (1Pi–12Pi) by reaction with phenylhydrazine followed by DDQ oxidation to produce the corresponding pyrazoles (1Pz–12Pz). Three 1-phenyl-3-t-butyl-5-arylpyrazoles (13Pz–15Pz) were synthesized using an analogous approach. Molecular modeling studies predicted the 5-aryl group of the pyrazoles for both series to have a torsion angle of 52°–54° whereas the 1-phenyl group was predicted to have 35°–37° torsion angles. The 3-aryl group was predicted to be essentially coplanar (−3°) with the pyrazole system in the first series. 13C NMR data for both series, 1Pz–12Pz and 13Pz–15Pz, were collected in DMSO-d
6 at 50°C. A plot of the C4 chemical shifts for 1Pz–12Pz versus Hammet constants for 5-aryl substituents yielded a very good linear correlation (R2=0.96) with a slope of 1.5. The chemical shift data for C4 showed little or no dependence on 3-aryl substituents. The result for 13Pz–15Pz, despite only three points, was consistent with the first series results and yielded a ρ value of 2.0. Distal transmission of substituent effects (5-aryl groups) to C4 of the pyrazole system was reduced by roughly 50–60% of that of the analogous planar isoxazole system, but are not consistent with results for the similarly twisted 4-bromoisoxazoles.
Shintani and Shimura lifts of cusp forms on certain arithmetic groups and their applications
Authors: Choi SoYoung , Kim Chang Heon 
Published: March 2017

Abstract
For an odd and squarefree level N, Kohnen proved that there is a canonically defined subspace

$S_{\kappa+\frac{1}{2}}^{\mathrm{n}\mathrm{e}\mathrm{w}}(N)\subset S_{\kappa+\frac{1}{2}}(N),\,\,{\text{and}}\,\,S_{\kappa+\frac{1}{2}}^{\mathrm{n}\mathrm{e}\mathrm{w}}(N)\,\,{\text{and}}\,\,S_{2k}^{\mathrm{n}\mathrm{e}\mathrm{w}}(N)$ are isomorphic as modules over the Hecke algebra. Later he gave a formula for the product

$a_{g}(m)\overline{a_{g}(n)}$ of two arbitrary Fourier coefficients of a Hecke eigenform g of halfintegral weight and of level 4N in terms of certain cycle integrals of the corresponding form f of integral weight. To this end he first constructed Shimura and Shintani lifts, and then combining these lifts with the multiplicity one theorem he deduced the formula in [2, Theorem 3]. In this paper we will prove that there is a Hecke equivariant isomorphism between the spaces

$S_{2k}^{+}(p)\,\,{\text{and}}\,\,\mathbb{S}_{k+\frac{1}{2}}(p).$ We will also construct Shintani and Shimura lifts for these spaces, and prove a result analogous to [2, Theorem 3].
Anti-inflammatory effect of D-pinitol isolated from the leaves of Colutea cilicica Boiss et Bal. on K562 cells
Authors: Eser Ferda , Mutlu Altundag Ergul , Gedik Gülsah , Demirtas Ibrahim , Onal Adem , Selvi Bedrettin 
Published: March 2017

Abstract

Aim
D-pinitol, a natural compound has shown various biological and pharmacological effects. Last studies are focused on the determination of its further pharmacological activities including mainly biological activity. Therefore, isolation of D-pinitol from the leaves of Colutea cilicica Boiss et Bal. and investigation of its apoptotic and anti-inflammatory activity on K562 cell lines were aimed in the concept of the study.

Materials and methods
Isolation of D-pinitol was performed by column chromatography. Chemical structure of the compound was confirmed by spectroscopic methods including 1H NMR, 13C NMR, 2D NMR, HPLC-TOF/MS, and IR. Cell viability was evaluated by dose and time dependent in K562 cell lines. D-pinitol was isolated from C. cilicica leaves for the first time.

Results
Stimulation of cells with D-pinitol (0–80 μM) was observed for 24, 48 and 72 h. It is determined that D-pinitol inhibited protein expression of Cox-2 in K562 cells. We observed that Poly (ADP-ribose) polymerase (PARP) protein expression did not change, but Cox-2 protein expression reduced with non-cytotoxic concentrations of D-pinitol.

Conclusion
It is concluded that D-pinitol did not affect cell proliferation and apoptosis in K562 cells however reduced the inflammation, significantly. These results show that D-pinitol may be anti-inflammatory agent for the treatment of K562 cells.
Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?
Authors: Eyre-Walker Adam 
Published: March 2017

Abstract
It has been suggested that deleterious interactions between the mitochondrial and nuclear genomes could pose a problem for mitochondrial replacement therapy (MRT). This is because the mitochondrial genome is placed in a novel nuclear environment using this technique. In contrast, it is inherited with half the mother’s genome during normal reproduction, a genome that it is relatively compatible with, since the mother is alive. Here, I review the evidence of whether mito-nuclear interactions are likely to pose a problem for MRT. The majority of the available experimental evidence, both in humans and other species, suggests that MRT is not harmful. These results are consistent with population genetic theory, which predicts that deleterious mito-nuclear interactions are unlikely to be much more prevalent in individuals born to MRT than normal reproduction, particularly in a species such as humans with low population differentiation. This is because selection is unlikely to be strong enough to establish significant linkage disequilibrium between the mitochondrial and nuclear genomes. These results are supported by a meta-analysis of 231 cases, from a variety of animals, in which the mitochondrial DNA (mtDNA) from one strain has been introgressed into the nuclear background of another strain of the same species. Overall, there is little tendency for introgression of mtDNA to be harmful.
Escala de atitudes frente à adoção: construção e validação
Authors: Brasileiro Tamíris Da Costa , Fonseca Patrícia Nunes da , Gouveia Rildésia Silva Veloso , Carvalho Thayro Andrade , Gouveia Valdiney Veloso 
Published: March 2017

Esta pesquisa objetivou elaborar a Escala de Atitudes frente à Adoção (EAFA), reunindo evidências de validade fatorial e consistência interna. Dois estudos foram realizados com a população geral de João Pessoa (PB). No Estudo 1 participaram 206 pessoas, maioria do sexo feminino (60%) e solteira (65%), com média de idade de 32 anos, que responderam a EAFA e perguntas demográficas. Os itens da medida apresentaram uma estrutura trifatorial, cujos alfas de Cronbach foram superiores a 0,70. No Estudo 2 participaram 215 pessoas, maioria do sexo feminino (51,6%) e solteira (48,4%), com média de idade de 33 anos. Por meio da análise fatorial confirmatória, observou-se que a estrutura trifatorial representou a melhor alternativa, cujos alfas de Cronbach foram superiores a 0,70. Conclui-se que esse instrumento reúne evidências de validade fatorial e confiabilidade, podendo medir atitudes frente à adoção na população geral.
The relationship between second-to-fourth digit (2D:4D) ratios and problematic and pathological Internet use among Turkish university students
Authors: Canan Fatih , Karaca Servet , Düzgün Melike , Erdem Ayşe Merve , Karaçaylı Esranur , Topan Nur Begüm , Lee Sang-Kyu , Zhai Zu Wei , Kuloğlu Murat , Potenza Marc N. 
Published: March 2017

Background and aims
The ratio of the second and fourth fingers (2D:4D ratio) is a sexually dimorphic trait, with men tending to have lower values than women. This ratio has been related to prenatal testosterone concentrations and addictive behaviors including problematic video-gaming. We aimed to investigate the possible association between 2D:4D ratios and Internet addiction and whether such a relationship would be independent of impulsivity.

Methods
A total of 652 university students (369 women, 283 men), aged 17–27 years, were enrolled in the study. Problematic and pathological Internet use (PPIU) was assessed using the Internet Addiction Test (IAT). The participants also completed the Barratt Impulsiveness Scale (version 11; BIS-11) and had their 2D:4D ratios measured.

Results
2D:4D ratios were not significantly different in women with PPIU and in those with adaptive Internet use (AIU). Men with PPIU exhibited lower 2D:4D ratios on both hands when compared with those with AIU. Correlation analysis revealed that 2D:4D ratios on both hands were negatively correlated with IAT scores among men, but not among women. The multiple linear regression analysis revealed that age, duration of weekly Internet use, impulsiveness, and 2D:4D ratios on the right hand were independently associated with IAT scores among men, and impulsivity did not mediate the relationship between 2D:4D ratios and PPIU.

Conclusions
For men, 2D:4D ratios on the right hand were inversely correlated with Internet addiction severity even after controlling for individual differences in impulsivity. These findings suggest that high prenatal testosterone levels may contribute to the occurrence of PPIU among men.
PENDIDIKAN MULTIKULTURAL PERSPEKTIF SAID AGIL HUSIN AL-MUNAWAR
Authors: Nadlir M 
Published: March 2017

<p>BAHASA INDONESIA:</p><p>Tulisan ini memaparkan pemikiran pendidikan multikultural menurut Said Agil Husin Al-Munawar. Dalam perspektif Said Agil Husin Al-Munawar, pendidikan multikultural di Indonesia dianggap sebagai sesuatu yang relatif baru di tengah masyarakat Indonesia yang heterogen. Menurut SAH Al-Munawar, agar siswa memiliki pribadi yang aktif dan kepekaan sosial yang tinggi terkait dengan kondisi multikultural, maka pendidikan multikultural di Indonesia dapat mencakup tiga hal jenis transformasi, yakni: 1. Transformasi diri; 2. Transformasi sekolah dan proses belajar-mengajar; 3. Transformasi masyarakat. Menurut SAH Al-Munawar, dengan belajar dari model-model pendidikan multikultural yang pernah ada yang sedang dikembangkan oleh negara-negara maju, maka dikenal lima model pendidikan multikultural, yaitu: <em>Pertama</em>, pendidikan mengenai perbedaan-perbedaan kebudayaan atau multikulturalisme penuh kebaikan. <em>Kedua</em>, pendidikan mengenai perbedaan-perbedaan kebudayaan atau pemahaman kebudayaan. <em>Ketiga</em>, pendidikan bagi pluralisme kebudayaan. <em>Keempat</em>, pendidikan dwi-budaya. <em>Kelima</em>, pendidikan multikultural sebagai pengalaman moral manusia.</p><p> </p><p>ENGLISH:</p><p>This paper describes the idea of multicultural education according to Said Agil Husin Al Munawar. In perspective of Said Agil Husin Al Munawar, multicultural education in Indonesia is regarded as something relatively new in Indonesia heterogeneous society. According to Al-Munawar, to make students have an active personal and social sensitivity associated with the multicultural, so the multicultural education in Indonesia can include three types of transformation: 1) Self-transformation; 2) The transformation of the school and the teaching-learning process; 3. Transformation of society. Based on Al-Munawar, learning from previous models of multicultural education which have been developed by the developed countries, then it is known as five multicultural education model, namely: First, education about cultural differences or benevolent multiculturalism. Second, education about cultural differences or cultural understanding. Third, education for cultural pluralism. Fourth, bi-cultural education. Fifth, multicultural education as a human moral experience.</p>
Avaliação das interações medicamentosas potenciais em prescrições de pacientes em Unidade de Terapia Intensiva
Authors: Garske Cristiane Carla Dressler , Brixner Betina , Freitas Alice Pereira , Schneider Ana Paula Helfer 
Published: March 2017

A identificação e prevenção de interações entre medicamentos estão diretamente relacionadas com a segurança do paciente e são de grande importância no ambiente hospitalar. O objetivo deste trabalho foi identificar e avaliar a existência de interações medicamentosas potenciais na farmacoterapia prescrita. Trata-se de estudo observacional, com 308 prescrições de 195 pacientes internados na Unidade de Terapia Intensiva de um hospital de ensino, realizado de agosto a dezembro de 2015. Para identificação das interações utilizou-se a base de dados Micromedex®. Das 308 prescrições analisadas, 101 apresentaram pelo menos uma interação medicamentosa, totalizando 173 interações, referentes a 71 pacientes. Destes, 43 eram do sexo masculino, com idade média de 61,9 anos. A média de internação na unidade foi de 7 dias. Nas 101 prescrições que apresentaram interações medicamentosas, foi prescrito o total de 1.349 medicamentos com média de 13,3 medicamentos/paciente/dia. Identificar essas interações possibilita evitar situações de insucesso terapêutico e toxicidade medicamentosa.
Physical disabilities in pregnant women: impact on care and pregnancy outcome
Authors: Chitnis Swati , Samant Padmaja 
Published: March 2017

Background: Health care providers are often insensitive to and unfamiliar with the needs of pregnant women with disability. Medical services are many times not tailored to the needs of the disabled. This study analyzes the impact of disabilities on pregnancy in women delivering in a tertiary care hospital in India.Methods: Prospective study of total of 50 pregnant women with various disabilities was conducted in a tertiary care hospital in Mumbai, India. Each patient’s antepartum, intrapartum and postpartum course were noted. Patients were also interviewed with help of a structured questionnaire for difficulties accessing services, and impact on their daily life, pain.Results: Rate of cesarean deliveries due to pelvic problems, and complications like urinary tract infections which arise due to mobility issues were significantly higher in patients with physical disabilities. 30% participants found examination tables unsuitable and 20% found it difficult access toilets. Over all patients were satisfied with skills of health workers.Conclusions: Healthcare facilities have to be equipped for receiving patients with disabilities and should train health workers in management of these clients. They require pre-conceptional counseling and planning.
Correlation between number of mature eggs retrieved and live birth rate in IVF treatment
Authors: Rana Lekshmy , Bavishi Himanshu , Bavishi Falguni 
Published: March 2017

Background: There is a strong association between the number of eggs and clinical pregnancy rates. But a few studies have shown conflicting results. Aim was to determine the relation between number of mature eggs retrieved and live birthrate in one complete IVF cycle (fresh and all frozen transfers included) and hence determine the optimum number of oocytes. Private IVF centre doing around 2000 cycles per year.Methods: Retrospective analysis of 1140 infertile women between 20 and 45 years who underwent self-stimulation IVf in our centre. Cumulativelive birth rate in one complete IVF cycle. Secondary outcome was the number of cases of moderate and severe OHSS.Results: Maximum LBR in patients where 10-15 egg were retrieved in fresh embryo transfer and cumulative LBR was maximum when more than 15 eggs were retrieved. No case of severe OHSS and one case of moderate OHSS in the group where more than 15 eggs were retrieved.Conclusions: The percentage of live birth increases with increasing number of mature eggs in IVF treatment. The incidence of OHSS was negligible.
Estudo do controlador orgânico derivado de biomaterial látex para correção da passada diabética utilizando a mudança qualitativa e quantitativa das cargas aplicadas ao pé
Authors: Montilla Perafán Diana Carolina , Alves Ribeiro Jaqueline , De Siqueira Rodrigues Fleury Rosa Suelia , Pinheiro Marques Marina , Delgado  Soares de Souza Afonso , Neves Lima Daniela 
Published: March 2017

Este trabalho apresenta o desenvolvimento e a inserção de um elemento externo denominado Diabets Ground Control (DGC) com base na etiologia mecânica do problema e avalia a variação das variáveis principais do sistema. O objetivo deste trabalho é propor um controlador para que por meio da mudança qualitativa e quantitativa das cargas aplicadas ao pé seja possível a correção da passada diabética. Essa interação controlada entre o pé diabético e o controlador é o que os autores defendem como a teoria de Controle Orgânico. Para obter o modelo matemático será usada a ferramenta Bond Graph (BG), um método alternativo as práticas clássicas de modelagem existentes introduzido por Paynter em 1961. Essa metodologia é fundamental para a concepção de uma teoria bio inspirada na área de Engenharia Biomédica, a teoria de Controle Orgânico. Dessa forma, a palmilha DGC permitirá a redistribuição da carga por toda a extensão da planta do pé sempre interagindo diretamente na resposta do sistema
Neonatal Sepsis in Low Birth Weight Infants in Dr. Soetomo General Hospital
Authors: Utomo Martono Tri 
Published: March 2017

Infections of the newborn are a significant cause of mortality. Preterm infant have a high risk sepsis.. The incidence of neonatal sepsis is 1 to 10 cases per 1000 live births and 1 per 250 live premature births. To describe the characteristics of neonatal sepsis in the low birth weight infant in the neonatal intensive care unit Dr. Soetomo Hospital. Retrospective analysis. The data were collected from the medical record of low birth weight infants who were diagnosed as sepsis in neonatal care unit of Dr. Soetomo Hospital between January 2010 to June 2010 with purposive sampling. Descriptive analysis of risk factor of sepsis and blood culture of the patient was calculated. Chi-square analysis was performed in the laboratorium data. Characteristics sample: male vs female 61% vs 39%, outcome of sepsis in LBW was death 69%, alive 25%, risk of infection: turbid amniotic fluid 21%, asphyxia 33%. Laboratorium data leucopenia and thrombocytopenia (P < 0.05). Blood culture: Klebsiella pnemoniae. The incidence and mortality of neonatal sepsis in LBW infants was still high. Asphyxia, turbid amniotic fluid, leucopenia and thrombocytopenia were associated with sepsis. pneumoniae was the most common organisms in the LBW sepsis infants.
THE EXON 5, 6, 7, 8 OF P53 MUTATIONS IN ORAL SQUAMOUS CELLS CARCINOMA
Authors: Rahayu Retno P 
Published: March 2017

Genetic instability may underlie the etiology of multistep carcinogenesis. The altered p53 gene observed in tumors may represent the expression of such instability and may allow the accumulation of other gene alterations caused by multiple mechanism. p53 gene is the guardian of the genome, that is why we pay more attention to this gene. In this study, we evaluated the significance of p53 mutation in 55 patient with oral squamous carcinoma. Thirty among them underwent well-differentiated carcinoma, while the remaining 25 patientsunderwent poorly differentiated carcinoma. The mutations were detected by PCR-SSCP (Single strand Conformational Polymorphism) analysis in the region between exon 5 and exon 8. The results indicated that the p53 mutation in exon 5 (40%), exon 6 (28%), exon 7 (24%) and exon 8 (8%) were associated with poorly differentiated carcinoma, whereas mutation in exon 5 (10%), exon 6 (30%), exon 7 (40%) and exon 8 (20%) were associated with well-differentiated carcinoma. These observations suggest that p53 mutation in exon5, 6, and 7 have strong correlation with poorly differentiated in oral squamous carcinoma while well-differentiated level was related with mutation in exon 6,7 and 8.
PLATELET RICH PLASMA PREPARATION PROTOCOLS: A PRELIMINARY STUDY
Authors: Nugraha Hans Kristian , Muljanti Meiti , Hernaningsih Yetti , Nugraha Jusak 
Published: March 2017

Currently, therapy with Platelet Rich Plasma (PRP) has been widely used and continues to grow for various clinical applications. Along with its development, there are various options in the method of obtaining PRP, either automatic or manual, while one of the most reliable methods according to the literature is a double centrifugation method. The purpose of this research is to produce anoptimization of the double centrifugation method. This study used experimental data obtained by conducting a research at the Clinical Pathology Laboratory of Dr. Soetomo Hospital, Surabaya. Experiments were conducted on stored blood obtained from the blood bag from Indonesian Red Crossand fresh blood from healthy donors with CPD anticoagulant. Results: PRP with optimum platelet count could be made with sufficient personal laboratory skills and amounted to 4.11 times with the platelet count of 1.152 million using 1300 rcf for 5 minutes for the first centrifugation, and 2300 rcf for 7 minutes for the second centrifugation.