bluuebunny/crossref_metadata_2025_split huggingface dataset:
E74‐like factor 4 promotes the proliferation, invasion, and migration of colorectal cancer cells via long non‐coding RNA integrin subunit beta 8 antisense RNA 1‐mediated histone H3 lysine 27 trimethylation modification
Authors: Wang Qi , Liu Shaofeng 
Published: September 2024

AbstractAimColorectal cancer (CRC) is a common malignancy in the gastrointestinal tract. The main objective of this study is to explore the potential mechanisms of E74‐like factor 4 (ELF4) in CRC progression, providing a novel therapeutic target for CRC treatment.MethodsCRC cells and normal control cells were cultured. Levels of ELF4/long non‐coding RNA integrin subunit beta 8 antisense RNA 1 (LncRNA ITGB8‐AS1)/claudin‐23 (CLDN23) were detected by real‐time quantitative polymerase chain reaction or Western blot assay. ELF4 siRNA, ITGB8‐AS1 pcDNA3.1, or CLDN23 siRNA were transfected into cells. Cell proliferation, migration, and invasion were evaluated. The enrichment of ELF4 on the ITGB8‐AS1 promoter was detected. Dual‐luciferase assay was employed to assess the binding between ELF4 and the ITGB8‐AS1 promoter. RNA pull‐down and RNA immunoprecipitation assays were conducted to investigate the binding between ITGB8‐AS1 and enhancer of zeste homolog 2 (EZH2). The binding of EZH2 and histone H3 lysine 27 trimethylation (H3K27me3) to the CLDN23 promoter was detected.ResultsELF4 and ITGB8‐AS1 were upregulated in CRC cells, while CLDN23 was downregulated. Knockdown of ELF4 inhibited cell proliferation, invasion, and migration. Mechanistically, ELF4 transcriptionally activated ITGB8‐AS1 and promoted the binding between ITGB8‐AS1 and EZH2. EZH2 catalyzed H3K27me3 modification on the CLDN23 promoter, leading to decreased CLDN23 expression. Overexpression of ITGB8‐AS1 or downregulation of CLDN23 could reduce the inhibitory effects of silencing ELF4 on CRC cell proliferation, migration, and invasion.ConclusionELF4 accelerates CRC progression through the ITGB8‐AS1/CLDN23 axis, providing new therapeutic targets for CRC.
Agricultural cooperative membership and welfare of maize farmers in Ethiopia: Insights from panel data analysis
Authors: Geffersa Abebayehu Girma 
Published: September 2024

AbstractThe emergence of agricultural cooperatives is widely viewed as a potential institutional arrangement that can help achieve rural poverty reduction by improving farmers’ welfare in developing countries. However, empirical evidence on the effect of cooperative membership on welfare and rural poverty in sub‐Saharan Africa remains limited. This paper examines the effect of cooperative membership on the welfare and poverty levels of maize‐farming households, using a comprehensive three‐wave panel dataset from three major maize‐producing regions in Ethiopia. The welfare effect of cooperative membership was estimated using a correlated random‐effects regression with a control function to account for unobservable heterogeneity and the endogeneity of cooperative membership. The findings show that cooperative membership significantly increased maize yield and enhanced the welfare of maize farmers by improving household income, subsequently leading to reductions in the prevalence of income poverty and the poverty gap. Further analysis reveals that while cooperative membership is pro‐poor in terms of its effect on maize yield, its effect on income and poverty tends to favour wealthier members with greater assets and extended landholdings. In this light, supporting poor and marginalized farmers with the resources needed would help improve the welfare gains from cooperative membership, thereby ensuring a more inclusive approach to poverty reduction.
Diallyl trisulfide alleviates dextran sulphate sodium‐induced colitis in mice by inhibiting NLRP3 inflammasome activation via ROS/Trx‐1 pathway
Authors: He Yue , Xiao Ling , Zhang Jing , Zhu Yanrong , Guo Yilei , Xia Yufeng , Zhao Huatou , Wei Zhifeng , Dai Yue 
Published: September 2024

AbstractDiallyl trisulfide (DATS), a sulphur‐containing compound isolated from the medicinal food plant garlic, has been previously reported to attenuate experimental colitis induced by either dextran sodium sulphate (DSS) or 2,4,6‐trinitrobenzenesulfonic acid (TNBS) in mice; however, the underlying mechanism remains to be identified. In this study, we deciphered the key mechanism by which DATS alleviates ulcerative colitis (UC). We showed that oral administration of DATS for 10 consecutive days greatly restrained the infiltration of macrophages and the pathological changes in colonic tissues of mice with DSS‐induced colitis. DATS treatment notably dampened the content of IL‐1β and IL‐18 and suppressed NLRP3 inflammasome activation in colon. Mechanistically, DATS effectively diminished the generation of ROS in macrophages. The suppressive effect of DATS on the activation of NLRP3 inflammasome and downregulation of IL‐18 and IL‐1β levels was blunted by xanthine oxidase. Further studies revealed that DATS inhibited NF‐κB pathway activation by suppressing the expression of Trx‐1, thereby inhibiting NLRP3 inflammasome activation. Trx‐1 overexpression and interference in macrophages promoted and diminished NLRP3 inflammasome activation, respectively. In summary, garlic and its main active ingredient DATS have potentials to prevent and treat UC, and DATS functions by inhibiting NLRP3 inflammasome activation via Trx‐1/ROS pathway.
Research on full‐colour gamut matching of wool blended yarn based on the Kubelka–Munk prediction algorithm
Authors: Zhu Wenshuo , Xue Yuan , Xue Jingli , Sun Xianqiang , Jin Guang 
Published: September 2024

AbstractThis article aims to solve the problems of a high inventory of coloured fibres, low efficiency of manual colour matching and poor repeatability in the woollen textile industry. Seven primary colour fibres were prepared based on seven selected primary colours, namely, red, yellow, green, cyan, blue, magenta and grey, which were then divided into six groups of ternary primary colour fibres. Next, six ternary coupling‐combination grid colour‐mixing models were constructed and merged into a full‐colour gamut grid colour‐mixing model. Based on this, 241 types of blended yarns and knitted fabrics were prepared. A colour‐matching system for wool colour‐spun yarns was constructed based on the Kubelka–Munk colour prediction algorithm and the full‐colour gamut grid colour‐mixing model. Training samples, test samples and validation samples are planned in each colour‐mixing area for constructing the colour‐matching system and validating its predictive performance. The results of spinning experiments show that full‐colour gamut spinning within the mixing range of seven primary colour fibres is achieved based on the constructed full‐colour gamut grid colour‐mixing model. The predicted results of test samples and validation samples show that the average colour difference between the predicted colour value and the measured colour value is 0.642, and the average error formed by the predicted blending ratio and the actual blending ratio of primary colour fibres is 0.0223. The results indicate that the constructed colour‐matching system achieved an accurate prediction of colour values and the blending ratio of primary colour fibres for blended yarns.
Interplay of Donor–Recipient Relationship and Donor Race in Living Liver Donation in the United States
Authors: Al‐Seraji Abdula , Adeyemo Simeon , Gurakar Ahmet , Shah Riya , Bunnapradist Suphamai , Lentine Krista L. , Redfield Robert R. , Gurakar Merve , Amin Alpesh N. , Muzaale Abimereki D. , Humar Abhinav , Al Ammary Fawaz , Alqahtani Saleh A. 
Published: September 2024

ABSTRACTIntroductionLiving liver donation improves survival of end‐stage liver disease (ESLD) patients. Yet, it continues to represent a small proportion of United States (U.S.) liver transplantation with existing racial disparities. We investigated the interplay of donor–recipient relationship and donor race to understand donor subgroups with no significant increase.MethodsWe studied 4407 living liver donors in the U.S. from January 1, 2012, to December 31, 2022 (median age = 36 years, and 59% were biologically related to the recipient). We quantified the change in the number of donors per 3‐year increment using negative binomial regression (incidence rate ratio [IRR]), stratified by donor–recipient relationship and race/ethnicity.ResultsAmong biologically related donors, the observed annual number of White donors increased from 146 to 253, Hispanic donors from 18 to 53, and Black donors decreased from 11 to 10. Among unrelated donors, White donors increased from 65 to 221, Hispanic donors from 4 to 25, and Black donors from 3 to 11. For the IRR of biologically related donors aged <40 and ≥40 years, White donors increased by 18% and 22%; Hispanic donors increased by 25% and 54%; and Black donors did not change. Likewise, the IRR of unrelated donors aged <40 and ≥40 years, White donors increased by 48% and 55%; Hispanic donors increased by 52% and 65%; and Black donors did not change.ConclusionsWhile biologically related donors represent the majority of donors, unrelated donors have substantially risen in recent years, primarily driven by White donors. Although the rate of unrelated donations increased among Hispanic donors, the absolute number remains very small (≤25 donors/year). Interventions are needed to increase education among Hispanic and Black communities to grow unrelated living liver donations across race/ethnicity.
The interdependence of targets for continuous glucose monitoring outcomes in type 1 diabetes with automated insulin delivery
Authors: Castañeda Javier , de Galan Bastiaan E. , van Kuijk Sander M. J. , Arrieta Arcelia , van den Heuvel Tim , Cohen Ohad 
Published: September 2024

AbstractAimThe aim was to determine the interdependence of targets for glucose management indicator (GMI), time within the ranges of 70–180 mg/dL (TIR) and 70–140 mg/dL (time in tight glucose range [TITR]), time above 180 mg/dL (TA180) and 250 mg/dL (TA250) and time below 70 mg/dL (TB70) and 54 mg/dL (TB54) and its implications for setting targets in automated insulin delivery (AID).Materials and MethodsReal‐world data from individuals with type 1 diabetes using the 780G system were used to calculate the receiver operating characteristic curves and establish interdependent targets for time in ranges based on several GMI benchmarks. Correlation, regression and principal component analysis were used to determine their association and dimensionality.ResultsIn individuals aged >15 years (n = 41 692), a GMI <6.5% required targets of >81%, >58%, <15% and <1.9% for TIR, TITR, TA180 and TA250, respectively, with high sensitivity, specificity and accuracy (>90%), whereas these values were poor for time in hypoglycaemia and GMI, which had a modest correlation (−0.21 to −0.43). Two dimensions emerged: (1) GMI, TIR, TITR, TA180 and TA250, and (2) TB70 and TB54, explaining 95% of total variability. GMI (or TIR) and TB70 explained >81% of the variability in the remaining continuous glucose monitoring (CGM) metrics, providing accurate predictions. Individuals aged ≤15 years (n = 14 459) showed similar results.ConclusionWe developed a methodology to establish interdependent CGM targets for therapies with CGM data outputs. In AID with the 780G system, a GMI <7% requires time in ranges close to consensus targets. Targets for GMI, TIR, TITR, TA180 and TA250 could be reduced to targets for GMI or TIR, whereas targets for time in hypoglycaemia are not inherently tied to GMI/TIR targets.
Global and regional estimates of hip fracture burden associated with type 1 diabetes from 1990 to 2021
Authors: Li Jing , Cui Hao‐Liang , Xie Dan‐Dan , Wang Qin‐Yi , Luo Chuo , Tian Lin , Shi Lin‐Ke , Sheng Zhi‐Feng 
Published: September 2024

AbstractAimTo assess the global and regional burden of hip fractures associated with type 1 diabetes (T1D) from 1990 to 2021.Materials and MethodsThe population attributable fraction was calculated by combining the published risk ratio with T1D prevalence (age ≥ 20 years) from the Global Burden of Disease study to estimate the T1D‐associated hip‐fracture burden. Trends were assessed using the age‐standardized incidence rate (ASIR) and estimated annual percentage change (EAPC).ResultsThe global incidence of T1D‐related hip fractures was 290 180 in 2021 with an ASIR of 3.96 (95% confidence interval: 1.92‐5.87) per 100 000 population and a male‐to‐female ratio of 0.54. At the super‐regional level, the highest incidence (204 610) and ASIR (13.09 per 100 000 population; 6.40‐25.53) were observed in high‐income regions, in particular in Australasia and Western Europe. Notably, Australasia exhibited the highest EAPC, 2.90% in T1D‐associated ASIR, followed by East Asia (2.73%). The incidence among those aged 45‐64 years grew significantly in 14 regions over the past decade. Nationally, the ASIR increased in 166 countries from 1990 to 2021.ConclusionsHigh‐income regions experienced the greatest burden of T1D‐associated hip fracture, while Australasia and East Asia witnessed the largest increase over the last 32 years. Prioritizing the promotion of T1D treatment and hip‐fracture screening for middle‐aged females living with T1D is crucial in these regions.
Comparative assessment of Ti‐6Al‐4 V titanium alloy fatigue life improvement by vibratory peening, shot peening, and vibratory finishing
Authors: Paques Maxime , Chakraborty Apratim , Changeux Benoit , Miao Hong Yan , Muhammad Waqas , Turenne Sylvain , Inal Kaan , Martin Etienne 
Published: September 2024

AbstractThe effects of vibratory peening (VP), shot peening (SP), and SP followed by vibratory finishing (SPVF) on the surface and fatigue properties of Ti‐6Al‐4 V were compared to conventional low‐stress grinding (LSG). VP processing produced seven times smoother surface finish than SP and 66% deeper compressive residual stresses (CRS) but with 12% lower magnitudes. SPVF produced optimal surface properties with a perfectly flat surface and CRS‐like SP. All three mechanical surface treatments generated similar fatigue life improvements (108–122%) over LSG when the cyclic stress was below the yield stress. Above the yield stress, most of the CRS relaxed during the first cycle in VP specimens, resulting in up to 97% fatigue life improvement over LSG. The CRS relaxed more gradually in SP specimens leading to larger (up to 239%) fatigue life improvement. This shows the need to amplify CRS magnitudes produced in VP to maximize fatigue life improvement.
Are investor‐paid credit ratings superior?
Authors: Qin Nan , Zhou Lei 
Published: September 2024

AbstractWe conduct pairwise comparisons of corporate bond ratings between three issuer‐paid credit rating agencies (CRAs) and one investor‐paid CRA regarding rating standard, accuracy, stability, and market impact. We find that neither compensation model results in more stringent or accurate ratings. While issuer‐paid S&P ratings are more stringent and accurate than investor‐paid Egan‐Jones ratings (EJR), issuer‐paid Fitch ratings are less stringent and have similar or lower accuracy compared to EJR ratings. In contrast, investor‐ and issuer‐paid ratings exhibit different rating change behaviors. EJR updates its ratings more frequently with fewer multinotch downgrades but also has a higher likelihood of rating reversals, while rating change behaviors are similar among the three issuer‐paid CRAs. Finally, issuer‐paid rating changes trigger stronger market responses.
Prevalence, correlates, and health indicators associated with meal‐skipping among middle‐aged and older adults in Thailand: A national longitudinal study
Authors: Pengpid Supa , Peltzer Karl , Anantanasuwong Dararatt 
Published: September 2024

AimThe purpose of this longitudinal study was to evaluate the prevalence and correlates of and the factors contributing to meal‐skipping in middle‐aged and older adults in Thailand.MethodsWe examined prospective cohort data from three consecutive waves of the Health, Aging and Retirement in Thailand (HART) study (analytic sample size = 2863) for participants 45 years of age and older. Meal‐skipping was assessed with a one‐ and two‐day recall of breakfast, lunch, and dinner. We used generalized estimating equations analysis to evaluate the longitudinal relationships between sociodemographic, lifestyle, and health indicators and meal‐skipping between 2015 (wave 1), 2017 (wave 2), and 2020 (wave 3). Furthermore, binary logistic regression was used to establish the longitudinal association between meal‐skipping and the incidence of multiple chronic conditions.ResultsThe prevalence of meal‐skipping was 6.2% in 2015, 16.2% in 2017, and 13.6% in 2020, and across study years the highest proportion of meal skipping was for lunch (6.0%), followed by breakfast (4.6%), and dinner (2.8%). In the final model, sociodemographic factors (higher education, urban residence, and lower subjective economic status), lifestyle factors (high alcohol use, current smoking, and obesity class II), and health indicators (probable depression and wearing dentures) were positively associated with meal‐skipping. In the adjusted logistic regression models, compared with no meal‐skipping, meal‐skipping in 2–3 study waves was associated with incident obesity and incident probable depression.ConclusionSkipping meals was linked to a number of lifestyle variables and indicators of physical and mental illness. Geriatr Gerontol Int 2024; 24: 1196–1202.
A survey of commercial soda–lime–silica glass compositions: Trends and opportunities II—Principal component analysis (PCA) of glass compositions
Authors: Deng Wei , Wakelin Elliot , Kilinc Erhan , Bingham Paul A. 
Published: September 2024

AbstractIn the first part of the study, we sampled and investigated the composition of commercial glasses in the UK market from 2022 to 2023, as well as property data provided by various models. In this part, we utilize principal component analysis (PCA) to conduct a comparative analysis, integrating these data with the composition of commercial glass documented in previous literature. The widely held belief that the composition of commercial soda–lime–silica glasses has remained essentially unchanged over the past 30+ years is challenged by this research. The differences in composition of current commercial glass compositions compared to glasses from 30 to 40 years ago have been quantified. This not only sheds light on the direction of travel and reasons for adjustments to UK glass compositions over recent decades, but it also provides insights and predictions into the future trends.
Turkish adaptation of the state–trait anxiety inventory short version (STAIS‐5, STAIT‐5)
Authors: Döner Seher , Efe Yağmur Sezer , Elmalı Ferhan 
Published: September 2024

AbstractAimThis study examines the validity and reliability of a Turkish version of the State–Trait Anxiety Inventory Short Version.MethodsThe sample consisted of 306 people between the ages of 18–59 who agreed to participate in the study and met the inclusion criteria. Data were collected with the demographic questionnaire, State–Trait Anxiety Inventory Short Version, State–Trait Anxiety Inventory and Brief Fear of Negative Evaluation Scale.ResultsAll factor loadings of the State Anxiety Inventory Short Version were between 0.706 and 0.835, and those of the Trait Anxiety Inventory Short Version were between 0.694 and 0.810. The Cronbach alpha coefficients of the State and Trait Anxiety Inventory Short Version were calculated as 0.838 and 0.837, respectively. There was a significant difference between the first‐test and retest values of the State Anxiety Inventory Short Version (p = 0.033) and no difference in the Trait Anxiety Inventory Short Version (p = 0.145).ConclusionsThe Turkish‐adapted State–Trait Anxiety Inventory Short Version is a valid and reliable measurement tool to determine the anxiety levels of individuals aged 18–59.
Injection Techniques to Reduce Adverse Effects of Subcutaneous Low‐Molecular‐Weight Heparin Among Patients With Cardiovascular Diseases: A Scoping Review
Authors: Wong Arkers Kwan Ching , Chu Rachel Yui Ki , Nan Ying , Cheng Huilin , Tong Danny , Leung Ming , Lam Harris , Chiu Sin Hing , Cheung Heung Wan , Chan Miu Ching , Chau Mei Yi , Lee Terence , Leung Yuen Wa , Mow Hoi Ching , Wan Sylvia , Wong Lee Yuen , Montarye Jed 
Published: September 2024

ABSTRACTAim(s)To systematically review the existing literature and address the following research question: What are the most effective techniques used to minimise adverse effects resulting from subcutaneous injections of low‐molecular‐weight heparin among patients with cardiovascular diseases?DesignA scoping review.MethodsA comprehensive search was conducted across multiple databases, including CINAHL, PubMed, EMBASE and the Cochrane Library, from 1 February 2014 to 31 January 2024. Participants were aged 18 years or older, diagnosed with venous thromboembolism or arterial thromboembolism and had prescribed subcutaneous injections of low‐molecular‐weight heparin. The collected data were analysed following the Joanna Briggs Institute approach, and it was organised and categorised based on the main objectives of the review.ResultsTwenty studies were eligible, including 1 best practice project, 7 randomised controlled trials and 9 quasi‐experimental studies. The techniques under investigation encompassed various aspects, including the injection site, injection duration (e.g., 30 s vs. 10 s), injection method (e.g., needle insertion angle), duration of needle withdrawal after injection, pressure application time and cold pressure. Preliminary evidence suggests that techniques such as using the abdominal site and slower injection rates may help reduce adverse effects. However, the optimal parameters for injection duration, waiting time, pressure and cold application, including the duration of these applications, remain uncertain due to limitations in sample size and heterogeneity in interventions and outcome measures across the studies.ConclusionsEnsuring the accurate administration of low‐molecular‐weight heparin is of utmost importance as it plays a critical role in decreasing mortality rates and minimising substantial healthcare costs linked to complications arising from incorrect administration. The findings from the current review have significantly contributed to strengthening the evidence base in this field, providing more robust and reliable information.Implications for the ProfessionThis review emphasises the significance of implementing standardised subcutaneous injection techniques for low‐molecular‐weight heparin in patients with cardiovascular disease in order to reduce complications and enhance patient outcomes.Reporting MethodThis study followed the applicable guidelines established by the PRISMA 2020 statement. The PRISMA checklist for systematic reviews was utilised for reporting purposes.Patient or Public ContributionThere is no patient or public contribution to declare.Trial RegistrationOSF registries: osf.io/phk72
Enforcement, Information or Socialization? The Role of the European Labour Authority in Protecting Mobile Workers in the EU
Authors: Blauberger Michael , Heindlmaier Anita 
Published: September 2024

AbstractThis article analyses the European Labour Authority (ELA) to understand the strategies EU agencies can use to improve EU rule implementation. Theoretically, we depart from established EU implementation and compliance research, broadly distinguishing between enforcement, information and socialization strategies. Empirically, the analysis draws on 18 semi‐structured background interviews with ELA and national officials and stakeholders as well as on documents from the negotiation of ELA's mandate, its first 5 years of operation and the review of the ELA regulation. We find that ELA tries to meet, at least partly, the high and diverse expectations of its stakeholders by pursuing a multitude of enforcement and information strategies in parallel. Given its limited resources to enforce and inform top‐down, however, most observers see the greatest potential for ELA in a socialization strategy, which prompts horizontal cross‐border co‐operation and builds trust amongst national enforcement authorities through joint inspections and liaison officers.