bluuebunny/crossref_metadata_2025_split huggingface dataset:
The value of chromosome instability detected by low−pass whole−genome sequencing in preoperative prediction of sentinel lymph node metastasis in breast cancer
Authors: Zheng Jian , Xu Fen , Li Guangying , Lin Moubin , Hao Hua 
Published: October 2024

BackgroundBreast cancer is a malignancy characterized by chromosomal instability (CIN). This study aimed to examine the potential diagnostic value of chromosomal instability, detected by low-pass whole-genome sequencing (LPWGS), in the preoperative evaluation of sentinel lymph node metastasis (SLNM) in breast cancer.MethodsA retrospective investigation of clinical records from 29 patients with breast cancer revealed two distinct groups based on sentinel lymph node biopsy (SLNB) results: the SLN metastasis group (24 cases) and the SLN non-metastasis group (five cases). CIN and CIN scores were evaluated using LPWGS. An analysis of univariate data and binary logistic regression was employed to identify factors influencing SLNM, and a curve with receiver operating characteristics (ROC) was constructed to assess the diagnostic utility of CIN in predicting SLNM.ResultsA significant association between the SLNM and CIN high groups was observed in breast cancer (P=0.011). The CIN score in the metastasis group (17,665.055 ± 8,630.691) was higher than that in the non-metastasis group (9,247.973 ± 3,692.873), demonstrating a significant difference (P=0.044). Univariate binary logistic regression analysis indicated that CIN was a significant predictor for SLNM (odds ratio: 4.036, 95% CI: 1.015–16.047, P=0.048). The AUC of CIN for preoperative diagnosis of SLNM was 0.808 (95%CI: 0.635–0.982, P=0.033), with a sensitivity value of 67.0% and specificity of 100.0% at a threshold of 13,563.ConclusionDetecting CIN through LPWGS demonstrates diagnostic potential in predicting SLNM in patients with breast cancer before surgery. This approach offers a novel method for assessing axillary lymph node status in clinical practice.
Assessment of synthetic MRI to distinguish Warthin’s tumor from pleomorphic adenoma in the parotid gland: comparison of two methods of positioning the region of interest for synthetic relaxometry measurement
Authors: Sun Jiabin , Kuai Xinping , Huang Dawei , Ji Xinghua , Jia Chuanhai , Wang Shengyu 
Published: October 2024

PurposeTo assess the diagnostic potential of the synthetic MRI (SyMRI) for differentiating Warthin’s tumors (WT) from pleomorphic adenomas (PA).Materials and methodsForty-nine individuals with parotid gland tumors (PA, n = 23; WT, n = 26) were recruited. Using two distinct regions of interest (ROI), SyMRI quantitative parameters of lesions were calculated, including mean and standard deviation (T1, T2, PD, T1sd, T2sd, and PDsd). Meanwhile, T1ratio, T2ratio, and PDratio (lesion/masseter muscle) were calculated based on the mean SyMRI quantitative parameters of masseter muscle (T1, T2, PD). Using the independent samples t test, we compared PA and WT parameters, while comparing the areas under the curve (AUC) using the DeLong’s test. A multi-parameter SyMRI model was constructed using logistic regression analysis.ResultsIn PA, the T1, T1sd, T2, PD, T1ratio, T2ratio, and PDratio derived from full and partial lesion ROIs were significantly higher than in WT. According to the receiver operating curve analysis, the AUC of the quantitative parameters derived from full-lesion and partial-lesion ROIs ranged from 0.722 to 0.983 for differentiating PA from WT. T1 values derived from partial-lesion ROI delineation demonstrated the best diagnostic performance among all single parameters, achieving an AUC of 0.983. Using 1322 ms as a cutoff value, the sensitivity, specificity, and accuracy were 88.46%, 100% and 93.88%, respectively.ConclusionThe SyMRI-derived quantitative parameters demonstrated excellent performance for discriminating PA from WT in the parotid gland.
Stress and career aspirations: a longitudinal study with medical students
Authors: Picker-Roesch Clara , Lang Jessica 
Published: October 2024

BackgroundThe psychological well-being of medical students has often been studied in relation to various factors and typically exhibits poorer scores than comparable student groups. This diminished well-being can have far-reaching implications, like impact on career or academic engagement. While there are some studies on specialty choice or academic performance few studies have examined the effects of stress at the beginning of medical school on career ambitions and the associated interest in research. Given the anticipated future shortage of healthcare professionals and the goal of gender equality in higher positions, it is crucial to examine this relationship as early as medical education. The question arises whether medical education and the demands of studying influence the career ambitions of different student groups.MethodAs part of a longitudinal survey, students from a medical cohort are surveyed over three consecutive years. A total of 297 students participated in the surveys, of which 66.4% were women. Stress experiences during medical school and career aspirations are assessed and analyzed using Generalized Estimating Equation (GEE) modeling.ResultsThe results indicate that early academic stress is a negative predictor of the career ambitions of medical students (B = 1.637; p = 0.009). Also, female students report lower career goals than male students (B = 1.168; p = 0.018). In addition, gender moderates the impact of stress on career ambitions (p = 0.046). Finally, stress levels are highest when starting the medical program (p = 0.022) and decrease over time.DiscussionStress during the initial medical training impedes students to pursue higher career ambitions. Future research as well as medical programs need to elaborate more on and consider structural stress prevention interventions in order to promote well-being and strengthen also scientific career goals at an early stage, specifically for female students.
Religion, spirituality, and pediatric mental health: a scoping review of research on religion and spirituality in the Journal of the American Academy of Child and Adolescent Psychiatry from 2000 to 2023
Authors: Elzamzamy Khalid , Naveed Sadiq , Dell Mary Lynn 
Published: October 2024

IntroductionReligion and spirituality (R/S) serve as sources of meaning-making and coping for many individuals and families. While research on the relationship between R/S and mental health has been ongoing, their role in pediatric mental health is poorly understood. The objective of this study is to assess research trends and predominant themes of R/S in child and adolescent psychiatric research in articles published in the Journal of the American Association of Child and Adolescent Psychiatry (JAACAP). This provides a rough measure of the relative importance of these topics to academic psychiatrists and researchers in the field and identifies gaps for future research.MethodsAll research and review articles published in JAACAP between 2000-2023 with a focus on R/S themes were retrieved, screened, and appraised for content and extent of focus on R/S (major, minor, incidental). Included articles were assessed for R/S variables and predominant themes.ResultsThirty-two (32) research articles published between 2000-2023 contained sufficient R/S content for inclusion in our study. Only 4 articles had R/S as their major focus. Our analysis suggested a decline in publications with R/S content over the last 24 years. The R/S variables and measurement tools were heterogenous, with religious attendance and religious affiliation being the most frequently measured variables. The predominant themes include the relationships between R/S and psychopathology, suicide, utilization of services, conceptualization of illness, trauma, identity, and coping.DiscussionDespite the significance attributed to R/S by many youths and families and the increasing academic interest in the intersection between R/S and health, a significant gap exists in our understanding of R/S vis-à-vis child and adolescent mental health. This gap may be further compounded by the limited attention offered to R/S factors and variables in academic psychiatric activities. JAACAP, a global leading academic platform, may advance this discourse by inviting and encouraging publications addressing R/S variables. This may inform diagnostic, preventive, and interventive clinical work with children and their families.
Deer antler stem cells immortalization by modulation of hTERT and the small extracellular vesicles characters
Authors: Chen Ze , Meng Deshuang , Pang Xin , Guo Jia , Li Tiejun , Song Jun , Peng Yinghua 
Published: October 2024

BackgroundDeer antler stem cells (AnSCs) exhibit properties of both embryonic and mesenchymal stem cells, with superior self-renewal and proliferation, which drive rapid antler growth and regeneration. AnSCs and their derived small extracellular vesicles (sEVs) hold promising potential for applications in regeneration medicine. Due to the restricted proliferative capacity inherent in primary cells, the production capacity of AnSCs and their sEVs are limited. Human telomerase reverse transcriptase (hTERT) is the most important telomerase subunit, hTERT gene insertion has been successfully employed in generating immortalized cell lines.ResultsIn this study, we successfully established immortalized AnSCs by transducing the hTERT gene using lentivirus. Compared to primary AnSCs, hTERT-AnSCs demonstrated extended passage potential and accelerated proliferation rates while maintaining the mesenchymal stem cell surface markers CD44 and CD90. Additionally, hTERT-AnSCs retained the capacity for osteogenic, adipogenic, and chondrogenic differentiation. sEVs derived from hTERT-AnSCs exhibited a particle size distribution similar to that of AnSCs, both displaying a cup-shaped morphology and expressing CD81, ALIX, and TSG101, while notably lacking GM130 expression.ConclusionWe successfully isolated primary stem cells from deer antler and established the immortalized hTERT-AnSCs. Remarkably, this cell line maintains its stem cell characteristics even after 40 passages. The sEVs derived from these cells exhibit identical morphological and structural features to those of primary AnSCs. This research provides essential technical support for the application of AnSCs and their sEVs in regenerative medicine.
An Age-Stage, Two-Sex Life Table for Megalurothrips usitatus Feeding on Eight Different Crop Plants
Authors: Wang Huanting , Huang Lifei , Zheng Xialin , Gong Rui , Cao Xuemei , Yang Lang 
Published: October 2024

Megalurothrips usitatus (Bagnall) feeds on the young tissues of plants, causing wilting and deformity of leaves as well as damage to flowers and fruits, thereby seriously affecting plant yield. Due to its small size and difficulty of control, the species is one of the most important pests in the legume family. To clarify the occurrence and damage pattern of M. usitatus on field crops, a study was conducted using eight different crops as experimental materials, and an age-stage, two-sex life table was constructed. The population density of M. usitatus was the highest on cowpeas (Vigna unguiculata L. Walp.), followed by green beans (Phaseolus vulgaris L.) and Vigna cylindrica (Vigna unguiculata subsp. cylindrica (L.) Verdc.) in terms of net reproductive rate and the intrinsic rate of increase. In terms of reproductive capacity, cowpeas and V. cylindrica were more suitable for M. usitatus growth and reproduction, followed by green beans. M. usitatus could develop into adults on courgettes (Cucurbita pepo L.), wax gourds (Benincasa hispida Thunb. Cogn.), Momordica charantia (Momordica charantia L.), and soybeans (Glycine max L. Merr.) but had difficulty reproducing on those plants. Cucumber (Cucumis sativus L.) was the least suitable for the survival of M. usitatus. Population parameter analysis showed that the cowpea was the most suitable host plant for M. usitatus, followed by green beans and V. cylindrica. M. usitatus had difficulty reproducing on courgette, wax gourd, M. charantia, and soybeans, and feeding on cucumbers inhibited M. usitatus development and reproduction.
FACTORS OF REALIZATION OF THE POTENTIAL OF CULTURAL HERITAGE IN THE SCHOOL EDUCATION SYSTEM
Authors: Коренная Валентина Сергеевна 
Published: October 2024

В статье акцентируется внимание на взаимосвязи объективных и субъективных факторов реализации потенциала культурного наследия в системе школьного образования. Подчеркивается значимость положений концепции экологии культуры Д. С. Лихачева для реализации Стратегии развития воспитания в Российской Федерации на период до 2025 года в контексте ценностно-нормативного подхода.
The article focuses on the relationship between objective and subjective factors in realizing the potential of cultural heritage in the school education system. The author emphasizes the importance of the provisions of the concept of ecology of culture by D.S. Likhachev for the implementation of the Strategy for the development of upbringing in the Russian Federation for the period up to 2025 in the context of the value-normative approach.
CONSERVATION OF CULTURAL HEGITAGE IN THE LIGHT OF THE AXIOLOGICAL THEORY OF CULTURE
Authors: Макарова Анастасия Сергеевна 
Published: October 2024

В статье рассматривается деятельность по сохранению культурного наследия в контексте аксиологического подхода к анализу культурных процессов. Реставрация представляется автором как особый вид этой деятельности, направленный на сохранение и актуализацию ценностных характеристик объектов - носителей культурных ценностей. Раскрывается понятие культурного наследия, приводится определение реставрационной деятельности, рассматриваются вопросы динамики культурных ценностей на примере изменения трактовки объекта реставрации в законодательных актах.
The article describes preservation of cultural heritage in the context of axiological approach to the cultural processes. Conservation is viewed as a special type of the preservation activity, performed to save and update the cultural value of objects. The author overviews definitions of the cultural heritage and conservation, analyzes the problem of dynamics of cultural values with an example of changes in interpretation of the conservation object given in legislative acts.
Organizational Culture dan Work Engagement terhadap Employee Performance dengan Social Loafing sebagai Variabel Intervening
Authors: Nilawati Nilawati , Ali Helmi 
Published: October 2024

Penelitian ini bertujuan untuk menganalisis dan menguji pengaruh budaya organisasi, keterlibatan kerja terhadap kinerja pegawai melalui kemalasan sosial di Dinas Perhubungan Kota Payakumbuh. Penelitian ini menggunakan pendekatan kuantitatif. Sampel yang digunakan mencakup seluruh pegawai Dinas Perhubungan Kota Payakumbuh, dengan metode pengambilan sampel menggunakan sensus, di mana seluruh populasi dijadikan sampel penelitian. Data primer diperoleh melalui kuesioner yang dibagikan langsung kepada seluruh pegawai Dinas Perhubungan Kota Payakumbuh, dengan total 39 kuesioner yang dikembalikan oleh semua responden. Analisis data dilakukan menggunakan Structural Equation Modeling (SEM) dengan aplikasi SmartPLS. Hasil penelitian menunjukkan bahwa budaya organisasi memiliki pengaruh positif yang tidak signifikan terhadap kinerja pegawai dan pengaruh positif yang tidak signifikan terhadap kemalasan sosial. Selain itu, keterlibatan kerja memiliki pengaruh positif yang signifikan terhadap kinerja pegawai, dan memiliki pengaruh positif yang signifikan terhadap kemalasan sosial. kemalasan sosial menunjukkan pengaruh negatif yang signifikan terhadap kinerja pegawai, Sementara itu, budaya organisasi berpengaruh negatif yang tidak signifikan terhadap kinerja pegawai dengan kemalasan sosial sebagai intervening, begitu juga keterlibatan kerja berpengaruh negatif dan tidak signifikan terhadap kinerja pegawai dengan kemalasan sosial sebagai intervening di Dinas Perhubungan Kota Payakumbuh
PENANAMAN POHON DAN SOSIALISASI PENGGUNAAN QR CODE KEPADA WARGA SEKITAR WANADESA SENDANGADI, MLATI, SLEMAN, YOGYAKARTA
Authors: Yuslinawari Yuslinawari 
Published: October 2024

ABSTRACTWanadesa is an environmental conservation area which includes a form of optimizing the use of village cash land through planting, plant enrichment, adding plant species and / or developing them. Wanadesa which is the location of community service (PkM) is Wanadesa Sendangadi, Kapanewon Mlati, Sleman Regency which has potential attractions of educational forests with various types of trees, including rare plants. The purpose of this PKM is to help the Government of Kalurahan Sendangadi develop wanadesa into an educational tourism forest through planting activities and socialization of QR code-based information systems for the introduction of wanadesa constituent tree species. The implementation method is the PkM INSTIPER Yogyakarta team making a QR code with theÂ Kalurahan Sendangadi Government team Â and socializing how to use it through counseling about biodiversity in this 4.0 era through the preparation of plant identity information with a QR code as well as enrichment of its type. PkM will be held from August to October 2023. The types grown as enrichment types are Ulin (Eusideroxylon zwagerii), Mersawa (Anisoptera marginata Korth.), Walikukun (Schoutenia ovata Korth.), Gondang (Ficus variegate) and Dlingsem (Homalium totemtosum). This PKM activity has produced a QR code-based information system for the introduction of Wanadesa Sendangadi constituent tree species. All PKM participants can understand and practice scanning QR codes using their smartphones as a tool to identify tree species diversity.Keywords: Tree Planting, Community Service, QR code, Socialization, Wanadesa Sendangadi.
Education On The Impact Of Gadget Use On Children's Health At SDN 2 Wonorejo Karanganyar
Authors: Solikah Siti Nur 
Published: October 2024

Technology is increasingly developing day by day following the development of world globalization. Gadgets as a communication tool are experiencing rapid development. Since Covid-19, gadgets have become children's friends in everyday life. Uncontrolled use of gadgets causes various health problems in children, such as decreased eye sharpness, behavioral disorders, social, emotional and psychological disorders in children. Education about the impact of gadget use on children is important to improve the level of health of children in Indonesia so that they grow and develop well in the future as a generation of the nation. The aim of this activity is to increase the knowledge and understanding of students at SDN 2 Wonorejo Karangayar regarding the impact of using gadgets on children's health. The implementation method was carried out using the health education method in the form of presentation of material and questions and answers targeting 23 elementary school age children. Based on the analysis of pre and post-test data, there was an increase in the average understanding of students in receiving information from the extension team. The recommendation for follow-up to this activity is that teachers coordinate with all parents in assisting them in using gadgets while at home and at school so that they do not affect children's health, so that optimal levels of children's health are achieved. Keywords: education, gadgets, health, children
Pengembangan Konsep Smart Government (Pemerintahan yang cerdas) di Kelurahan Sindangsari Kecamatan Pasarkemis Kabupaten Tangerang
Authors: Aprilianti Baby Novega , Yusuf Yusmedi , Suherman Agus 
Published: October 2024

Pada penelitian ini membahas pengembangan konsep Smart Government. Dapat diketahui Smart Government adalah pengembangan dari konsep pemerintahan cerdas untuk memberikan solusi bagi masalah di wilayah pedesaan. Metode penelitian ini menggunakan metode kualitatif deskriptif. Teknik pengumpulan data menggunakan wawancara, observasi, dan dokumentasi. Teknik analisis data pada penelitian ini yaitu: pengumpulan data, reduksi data, penyajian data dan menarik kesimpulan. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pengembangan konsep smart government di Kelurahan Sindangsari dan apa saja hambatan yang ditemukan dari pengembangan smart government tersebut beserta upaya mengatasinya. Hasil penelitian dapat diukur dengan menggunakan ketiga indikator smart government menurut Cohen (2014) dalam (Santoso & Rahmadanita, 2020) yaitu: Online Service, Infrastructure, Open Government. Adapun hasil penelitian ini menunjukan konsep smart government di Kelurahan Sindangsari pada indikator Online Service sudah menunjukan hasil yang dikatakan baik sedangkan pada indikator infrastructure dan Open Government menunjukan hasil yang belum optimal dikarenakan adanya keterbatasan sumber daya anggaran dan sumber daya manusia sehingga mempengaruhi kapasitas pihak Kelurahan Sindangsari dalam menyediakan sarana berbasis teknologi informasi dan komunikasi. Maka dari itu diperlukan adanya peningkatan pada kedua indikator tersebut.
Katakunci: Pengembangan, Smart government, Teknologi Informasi dan Komunikasi, Website
PENGARUH WORK CLIMATE, SELF-EFFICACY DAN JOB INSECURITY TERHADAP KINERJA KARYAWAN PADA PT AVO INNOVATION & TECHNOLOGY DI YOGYAKARTA
Authors: Ma’rifah Ririn , Darmawan Surya 
Published: October 2024

Tujuan dari penelitian ini yaitu menganalisis hubungan antara Work Climate, Self-Efficacy dan Job insecurity terhadap kinerja karyawan. Penelitian ini menggunakan teknik pengambilan sampling dengan teknik purposive sampling, dengan jumlah responden sebanyak 176 reponden (87 pria dan 89 perempuan), populasi dalam penelitian ini yaitu karyawan pada PT Avo Innovation dan Technology. Data primer dalam penelitian ini dikumpulkan dengan menggunakan metode kuesioner melalui google form yang telah diuji validitas dan reabilitasnya. Dalam penelitian ini, software SmartPLS 4.0 yang digunakan dengan analisis statistik deskriptif, outer model dan inner model. Hasil penelitian ini menunjukkan bahwa work climate berpengaruh positif dan signifikan terhadap kinerja karyawan. Self-Efficacy berpengaruh positif dan signifikan terhadap kinerja karyawan. Job insecurity berpengaruh positif dan signifikan terhadap kinerja karyawan. Work climate, self efficacy, job insecurity secara simultan berpengaruh positif terhadap kinerja karyawan
بناء منهج مقترح لتدريس مادة اللغة العربية العامة لأقسام غير الاختصاص كليات التربية للبنات على وفق معايير الاعتماد الاكاديمي
Authors: زهراء رخيت عكله  , أ.د قصي عبد العباس حسن الابيض  
Published: October 2024

يهدف البحث الحالي الى تعرف " بناء منهج مقترح لتدريس مادة اللغة العربية العامة لأقسام غير الاختصاص كليات التربية للبنات على وفق معايير الاعتماد الاكاديمي " ولتحقيق هدف البحث اعتمد الباحثان منهج البحث الوصفي ثم اتبعا الخطوات الاساسية لبناء المنهج المقترح والمتمثلة بتحديد الاهداف العامة لمادة طرائق التدريس العامة ، واختيار المحتوى التعليمي ، وتحليل خصائص الطالبات ، وتحليل البيئة الصفية ومن ثم صاغ الباحثان الاهداف السلوكية ونظما المحتوى التعليمي ، وحددا طرائق التدريس المتبعة ، كما حددا الانشطة التعليمية اللازمة ، واجريا التقويم اللازم للمنهج المقترح فاتبع الباحثان ثلاث انواع من التقويم التمهيدي والتكويني والختامي ، وبعد اكمال الباحثان لبناء المنهج ومستلزماته عرضاه بصورته الاولية على مجموعة من الخبراء والمحكمين في مجال اللغة العربية وطرائق التدريس وعلم النفس والقياس والتقويم للتأكد من صدقه ، قود حصل المنهج على نسبة اتفاق (95%) من الخبراء على المنهج وفي ضوء ملحوظاتهم تم اجراء بعض التعديلات ، وقد أسفرتْ النتائج على بناء المنهج المقترح وقد خرج البحث الحالي بعدد من الاستنتاجات منها أن استعمال المنهج المقترح قد يسهم في زيادة نشاط الطالبات وفاعليتهن وميلهن نحو مادة العربية العامة ، كما اوصى الباحثان بعدد من التوصيات منها اعتماد المنهج المقترح في تدريس مادة العربية العامة لاقسام غير الاختصاص في كلية التربية للبنات واقترح الباحثان عدد من المقترحات منها إجراء دراسة مماثلة للدراسة الحالية على متغيرات اخر .