bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activation of TRPV4 Increases Neovascularization of Rat Prefabricated Flaps
Authors: Bae Jinhong , Wang Zhichao , Li Haizhou , Lu Lin , Yu Qingxiong , Li Qingfeng , Tao Zan 
Published: September 2017

Background Inadequate neovascularization is a major risk factor that can lead to subsequent necrosis of prefabricated flaps. Recent evidence indicates that transient receptor potential cation channel, subfamily V, member 4 (TRPV4) activates growth and remodeling of collateral arteries in ischemia tissues by responding to elevated fluid shear stress (FSS). Therefore, we evaluated whether TRPV4 could increase neovascularization in prefabricated flaps in a rat model.
Methods Rat prefabricated skin flaps were created by ligating the right femoral vascular pedicle and implanting it underneath abdominal flaps. Thirty-six male Sprague–Dawley rats were randomly assigned to three groups with different solutions injected subcutaneously in the implantation site around the pedicle: injected with normal saline as the control group; injected with 4α-Phorbol 12,13-didecanoate (4αPDD), a specific TRPV4 activator, as the 4αPDD group; or injected with ruthenium red (RR), a TRPV-blocker, as the RR group. Neovascularization was evaluated by laser speckle contrast imaging (FLPI), histological staining, and enzyme-linked immunosorbent assay (ELISA) within two weeks. Afterwards, the abdominal island flaps were completely elevated and sutured back. The flap viability and survival area were examined on day 7.
Results A larger area of flap survival, higher capillary densities, and higher von Willebrand factor (vWF) expression were observed in the 4αPDD group in comparison to those in the other two groups. The secretion of vascular endothelial growth factor (VEGF), but not basic fibroblast growth factor (bFGF), was significantly elevated in the 4αPDD group.
Conclusion Activation of TRPV4 using 4αPDD can significantly increase the survival of prefabricated flaps via neovascularization inducement, possibly through VEGF secretion enhancement. TRPV4 serves as a potential therapeutic neovascularization target in prefabricated flaps.
Ultraschall bei Vaskulitiden
Authors: Schmidt W. 
Published: September 2017

ZusammenfassungMittels Ultraschall lässt sich eine pathognomonische Gefäßwandschwellung bei Vaskulitiden an Temporalarterien und an extrakraniellen Arterien nachweisen. Die Sonografie ist wichtiger Bestandteil in der Diagnostik der Arteriitis temporalis, der Riesenzellarteriitis großer Gefäße und der Takayasu Arteriitis geworden. Durch „Fast Track Clinics“ in denen gleichzeitig fachärztliche klinische Untersuchung und Sonografie mindestens von Temporal- und Axillararterien angeboten wird, kann die Inzidenz von Erblindungen reduziert werden.
Mehr als ein bisschen Berieselung
Authors: Becker Alexander 
Published: September 2017

Zusammenfassung
Interventionskoffer, die Zehnte Viele Patienten schalten in ihrer Freizeit den Fernseher ein und lassen sich berieseln. Hier setzt das
Konzept der DVD-Gruppe an: Die Teilnehmenden lernen, ihre Freizeit bewusst zu gestalten, soziale Kompetenzen zu trainieren und sich – je
nach Film – kritisch mit dem Thema „psychische Erkrankung“ auseinanderzusetzen. Die Pflegenden müssen dabei weit mehr leisten, als eine DVD
einzulegen und Chips in Schüsseln zu füllen. In unserem Interventionskoffer schildern wir Planung, Ablauf und Erfahrungen des
Gruppenkonzepts zum Thema Freizeitgestaltung – das viel mehr ist als ein bisschen Berieselung nach dem Abendessen.
Gut vernetzt
Authors: Blumenrode Stefan 
Published: September 2017

Zusammenfassung
Menschen mit Demenz im Akutkrankenhaus Was können wir von Norwegen lernen, um Demenzerkrankte gut zu versorgen? Anregungen gab eine
Studienreise in den hohen Norden zum Thema „Menschen mit Demenz im Akutkrankenhaus“, die vom 29. Mai bis 02. Juni 2017 stattfand.
Organisiert wurde sie vom Institut g-plus – Zentrum im internationalen Gesundheitswesen in Zusammenarbeit mit der Universität Witten. Lesen
Sie, welche Eindrücke unser Autor bei Vorträgen und Führungen in norwegischen Krankenhäusern sammeln konnte.
Individuelle Hilfe
Authors: Schabert Martina , Seibold Angelika , Witzmann Markus 
Published: September 2017

Zusammenfassung
Autismus-Spektrum-Störung Was verbirgt sich hinter der Diagnose Autismus und mit welchen Angeboten können Betroffene unterstützt
werden, um am gesellschaftlichen Leben teilzuhaben und ihre Lebensqualität nachhaltig zu verbessern? Wir stellen Ihnen die
Autismuskompetenzzentrum Oberbayern gGmbH vor, die es sich zur Aufgabe gemacht hat, rund um das Thema Autismus zu beraten sowie individuelle
Hilfen in allen Lebensbereichen zu vermitteln und anzubieten.
Selbstbestimmt handeln
Authors: Bell Erpho 
Published: September 2017

Zusammenfassung
Empowerment Viel zu selten wird Empowerment bewusst im Pflegealltag genutzt. Doch wie mache ich Pflege stark in Fort- und
Weiterbildung? Unser Autor plädiert für mehr konstruktivistische Pädagogik, um die „Ermächtigung“ der Pflege zu stärken.
Zugang finden
Authors: Dörflinger Rupert 
Published: September 2017

Zusammenfassung
Empathie in der Praxis Wie entwickelt sich Empathie im Verlauf einer herausfordernden Beziehung mit dem Patienten und welche Bedeutung
spielt die Gegenübertragung? Anhand von zwei spezifischen Behandlungssituationen erläutert unser Autor, mit welchen Hürden bei der
praktischen Umsetzung zu rechnen ist und wie ein professioneller Umgang aussehen kann.
The Energy Cost of Running with the Ball in Soccer
Authors: Piras Alessandro , Raffi Milena , Atmatzidis Charalampos , Merni Franco , Di Michele Rocco 
Published: September 2017

AbstractRunning with the ball is a soccer-specific activity frequently used by players during match play and training drills. Nevertheless, the energy cost (EC) of on-grass running with the ball has not yet been determined. The purpose of this study was therefore to assess the EC of constant-speed running with the ball, and to compare it with the EC of normal running. Eight amateur soccer players performed two 6- min runs at 10 km/h on artificial turf, respectively with and without the ball. EC was measured with indirect calorimetry and, furthermore, estimated with a method based on players’ accelerations measured with a GPS receiver. The EC measured with indirect calorimetry was higher in running with the ball (4.60±0.42 J/kg/m) than in normal running (4.19±0.33 J/kg/m), with a very likely moderate difference between conditions. Instead, a likely small difference was observed between conditions for EC estimated from GPS data (4.87±0.07 vs. 4.83±0.08 J/kg/m). This study sheds light on the energy expenditure of playing soccer, providing relevant data about the EC of a typical soccer-specific activity. These findings may be a reference for coaches to precisely determine the training load in drills with the ball, such as soccer-specific circuits or small-sided games.
Pivotal Role of TNF-α in the Development and Progression of Nonalcoholic Fatty Liver Disease in a Murine Model
Authors: Kakino Satomi , Ohki Tsuyoshi , Nakayama Hitomi , Yuan Xiahong , Otabe Shuichi , Hashinaga Toshihiko , Wada Nobuhiko , Kurita Yayoi , Tanaka Kayo , Hara Kento , Soejima Eri , Tajiri Yuji , Yamada Kentaro 
Published: September 2017

AbstractPreviously, we have shown that the adipocyte-specific nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c) transgenic mice spontaneously developed hepatic lesions that are similar to those of human nonalcoholic steatohepatitis (NASH) with a concomitant elevation of plasma TNF-α. In this study, we analyzed the role of TNF-α in the progression of nonalcoholic fatty liver disease (NAFLD). We established a Tnf knockout nSREBP-1c transgenic mouse line. Glucose tolerance and liver histology were examined at the age of 20 weeks. The gene expression and protein levels were assessed by quantitative RT-PCR and Western blot, respectively. The Tnf knockout improved glucose tolerance and significantly reduced the prevalence of hepatic steatosis (20% vs. 100%, p<0.0001) and fibrosis (15% vs. 65%, p=0.0057). The expressions of Acaca, Scd1, Mcp1, Tgfb1, Col1a1, and Timp1 were increased in the liver from the original nSREBP-1c transgenic mice. However, gene upregulation was reduced in the livers from the Tnf(−/−) nSREBP-1c transgenic mice. Furthermore, the hepatic levels of TIMP1 protein were increased in the original nSREBP-1c transgenic mice but not in Tnf(−/−) nSREBP-1c transgenic mice. To assess the direct effect of TNF-α on the expression of the genes, we cultured primary hepatocytes in the presence of TNF-α and found that TNF-α increased the expression of Mcp1, Tgfb1, and Timp1 in hepatocytes. These observations indicate that TNF-α plays a pivotal role in the development of NAFLD and progression to NASH through upregulating key molecules associated with lipid metabolism, inflammatory cytokines, and fibrosis in the liver.
Clinical Characteristics and Long-Term Outcome of Primary Aldosteronism in a Norwegian Population
Authors: Grytaas Marianne , Strømsøy Siri , Rørvik Jarle , Arnes Jarle , Heie Anette , Arnesen Thomas , Jørstad Melissa , Nedrebø Bjørn , Jøssang Dag , Jensen Dag , Rørvik Håvard , Sagen Jørn , Mellgren Gunnar , Thordarson Hrafnkell , Husebye Eystein , Løvås Kristian 
Published: September 2017

AbstractPrimary aldosteronism (PA) is the most common cause of secondary hypertension (HT). We describe here clinical characteristics, diagnostic procedures, and long-term outcomes in a Norwegian population. All suspected PA patients investigated at a tertiary centre from 1998–2012 were retrospectively evaluated. Inclusion criteria were verified PA after confirmatory testing or otherwise considered highly likely PA. Clinical, biochemical, radiological, and adrenal vein sampling (AVS) findings were analysed. Surgically removed adrenals were re-evaluated histopathologically and tested for somatic mutations. All patients still alive by August 2014 were invited to a follow-up visit. One-hundred and eight patients were included, of whom 85% had a history of hypokalaemia. PA was verified by confirmatory testing in 83 (77%), and AVS performed in 95 (88%) patients. The proportion with AVS-confirmed bilateral PA increased during the study period. Sixty-eight patients (63%) underwent adrenalectomy. KCNJ5 mutations were found in 30% of the surgical specimens and were associated with female sex and a florid PA phenotype. Follow-up visits were undertaken in 73/108 (68%), of whom 52 adrenalectomised. After adrenalectomy, 83% were biochemically cured of PA, but only 21% were cured for HT. Female sex, a verified adenoma, and KCNJ5 mutations were associated with cure of HT. In conclusion, the majority of our patients had unilateral PA and hypokalaemia, indicating that patients with bilateral and milder PA may still be underdiagnosed. Female sex, a histopathological adenoma, and the presence of KCNJ5 mutations predicted cure of HT after adrenalectomy, but the overall cure rate of HT was low.
Serum Uric Acid Concentrations Can Predict Hypertension: A Longitudinal Population-Based Epidemiological Study
Authors: Zheng Rongjiong , Yang Tianmeng , Chen Qingmei , Chen Changxi , Mao Yushan 
Published: September 2017

AbstractAn elevated serum uric acid concentration may be associated with hypertension, which is the leading cause of death worldwide. However, whether the elevation is causal or a consequence of hypertension among the Chinese population remains unclear. This study was designed to investigate the longitudinal relationship between the serum uric acid concentrations and hypertension among Chinese individuals. This study included 5105 subjects, initially without hypertension, who were followed up for 9 years. The subjects were divided into four groups based on the serum uric acid quartile. Cox proportional hazard models were used to analyse the risk factors for hypertension development. Over the 9 years, 2259 of the subjects developed hypertension. The overall 9-year cumulative incidence of hypertension was 44.3%, ranging from 36.3% in quartile 1 to 42.4%, 44.1%, and 54.5% in quartiles 2, 3, and 4, respectively (p for trend<0.001). The Cox regression analyses indicated that the serum uric acid concentrations were independently and positively associated with the risk of incident hypertension. This longitudinal study demonstrated that high serum uric acid concentrations increase the risk of hypertension among the Chinese population.
Microphone pokes as prank or political action?
Authors: Kroon Åsa , Angus Daniel 
Published: September 2017

Abstract
The production of political talk is changing in response to ongoing changes in the overall media ecology. The rise of web TV
challenges the previously dominant mediated politics of traditional broadcasting. In this paper we examine the practices of the
mediatization of politics in the web TV environment via a humorous encounter between a self-declared “prankster” posing as a web
TV broadcaster, and several Swedish politicians. The discussion reflects on various data emanating from this encounter to reveal
how Web TV challenges traditional broadcasting norms, and offers fresh challenges for politicians who are continuously adapting to
new media logics for exposure.
A sentiment democracy?
Authors: Ceron Andrea 
Published: September 2017

Abstract
Does the interaction with the opinions of ‘friends’ and ‘followers’ affect the behavior of politicians? So far, little attention has been devoted to the effect of social networking sites (SNS) on ‘hard politics’ choices. Focusing on two case studies related to Italian politics, namely the debate on the civil unions bill and the ‘Fertility Day’ crisis, in 2016, this paper tries to fill this gap assessing the influence of SNS on the behavior of politicians. For this purpose, supervised aggregated sentiment analysis and time series analysis are used to evaluate whether politicians surrender to the pressure put on them by their followers. The findings highlight some positive effects in terms of accountability/transparency, though in terms of responsiveness politics seems to continue as usual, and the road toward a full ‘sentiment democracy’ is still far ahead.
Habitat Quantity Required to Support Self‐Sustaining Lake Sturgeon Populations: an Alternative Hypothesis
Authors: McDougall C. A. , Nelson P. A. , Macdonald D. , Kroeker D. , Kansas K. , Barth C. C. , MacDonell D. S. 
Published: September 2017

AbstractCiting the capacity of anadromous sturgeon species to undertake lengthy spawning migrations, Auer (1996) hypothesized that a minimum of 250–300 km of barrier‐free lake and river habitat might be required to support self‐sustaining populations of Lake SturgeonAcipenser fulvescens. Twenty years later, the biological understanding of this potamodromous species has improved considerably, but there has been minimal effort to reconcile the barrier‐free hypothesis with the persistence of Lake Sturgeon populations in impounded habitats and improve the understanding of what constitutes a functional population‐level habitat unit for this species of conservation concern. Herein, POPAN mark–recapture models and sequential length‐frequency histograms were used to examine contemporary Lake Sturgeon abundance and population trajectories in three small reaches (230, 50, and 10 river kilometers [rkm]) of the Nelson and Winnipeg rivers (Manitoba), developed for hydroelectric power generation. Approximately two decades after harvest closures, results indicate that population recovery is occurring in all three reaches examined. Mechanisms other than in situ reproduction or recruitment (i.e., stocking and immigration) for increasing abundance are confidently discounted. Based on these results and other observations of contemporary persistence of Lake Sturgeon populations in impounded environments as well as recent genetic observations indicative of historical population structuring along the flow axes of naturally fragmented Boreal Shield rivers, it is contended that the barrier‐free hypothesis should no longer be cited as a “rule of thumb” with regard to the habitat quantity required to support self‐sustaining Lake Sturgeon populations. Rather, the concept of an uninterrupted “spawn–drift–settle–establish” habitat sequence as the cornerstone of a functional population‐level habitat unit may have broader relevance to species recovery initiatives and management. Given appropriate geomorphologic and hydraulic conditions, Lake Sturgeon populations can thrive—and in Boreal Shield rivers likely have for thousands of years—in lake, river, or impoundment sections as small as 10 rkm.
Impact of Free Trade Agreement Use on Import Prices
Authors: Hayakawa Kazunobu , Laksanapanyakul Nuttawut , Mukunoki Hiroshi , Urata Shujiro 
Published: September 2017

Abstract
We examine the impact of free trade agreement (FTA) use on import prices. For this analysis, we employ establishment-level import data with information on tariff schemes, that is, the FTA and most-favored-nation schemes used for importing. Unlike previous studies, we estimate the effects of FTA use on prices by controlling for differences in importing-firm characteristics. There are three main findings. First, the effect of FTA use is overestimated when not controlling for importing firm-related fixed effects. Second, on average, firms’ FTA use reduces tariffs by 12 percentage points and raises import prices by 3.6–6.7 percent. Third, in general, we do not find a price rise resulting from the costs of complying with rules of origin.
Bolstering your armamentarium with SGLT2 inhibitors
Authors: Novak Lucia M. , Kruger Davida F. 
Published: September 2017

Abstract:
Sodium-glucose cotransporter-2 inhibitors have a unique mechanism of action in the kidneys that causes glucosuria, which lowers plasma glucose. They are also associated with reduced body weight and BP, and a low incidence of hypoglycemia. This article reviews the pharmacologic profiles and clinical implications of canagliflozin, dapagliflozin, and empagliflozin.
A randomized, multicenter, double-blind study to evaluate the safety and efficacy of estradiol vaginal cream 0.003% in postmenopausal women with dyspareunia as the most bothersome symptom
Authors: Kroll Robin , Archer David F. , Lin Yuhua , Sniukiene Vilma , Liu James H. 
Published: September 2017

Abstract

Objective:
Vulvovaginal atrophy (VVA) is characterized by vaginal changes, dyspareunia, and itching/irritation. Efficacy and safety of a lower-dose estradiol vaginal cream (0.003%) were evaluated in postmenopausal women with VVA-related dyspareunia.

Methods:
This was a phase 3, randomized, double-blind, placebo-controlled study. Sexually active postmenopausal women with moderate–severe dyspareunia as the most bothersome symptom, ≤5% vaginal superficial cells, and vaginal pH >5.0 were randomized (1:1) to 0.003% estradiol vaginal cream (15 μg estradiol; 0.5 g cream) or placebo (0.5 g cream) applied daily for 2 weeks followed by three applications/week for 10 weeks. Coprimary outcomes were changes in dyspareunia severity, vaginal cytology, and vaginal pH from baseline to final assessment. Additional efficacy outcomes and safety were assessed.

Results:
A total of 550 participants (average age, 58 y) were randomized. Compared with placebo, estradiol reduced dyspareunia severity (mean change from baseline ± SD: −1.5 ± 1.0 estradiol vs −1.2 ± 0.9 placebo), decreased vaginal pH (−1.36 ± 0.89 vs −0.53 ± 0.92), and improved vaginal cytology (percentage superficial and parabasal cells 10.1 ± 16.7 vs 1.4 ± 6.1 and −48.5 ± 45.1 vs −14.6 ± 39.6; P < 0.001, all) at the final assessment. In addition, estradiol decreased dyspareunia severity at weeks 8 and 12, vaginal/vulvar irritation/itching at weeks 4 and 12, and dryness at week 12 versus placebo (P < 0.01, all). VVA severity, pH, and cytology improved at week 12 with estradiol versus placebo (P < 0.001, all). Vulvovaginal mycotic infections were more frequent with estradiol. One serious event leading to discontinuation occurred with estradiol. No deaths occurred.

Conclusions:
Lower-dose estradiol vaginal cream (0.003%) dosed three applications/week is an effective and well-tolerated treatment for VVA-related dyspareunia.
Alcohol and Drug Use Before and During the First Year After Traumatic Brain Injury
Authors: Beaulieu-Bonneau Simon , St-Onge Frédéric , Blackburn Marie-Claude , Banville Andrée , Paradis-Giroux Andrée-Anne , Ouellet Marie-Christine 
Published: September 2017

Objectives:
To compare individuals with mild and moderate/severe traumatic brain injury (TBI) on alcohol and drug use and substance use disorders before and in the first year post-TBI; to explore sociodemographic and injury-related variables associated with substance use disorders.

Participants:
A total of 225 adults hospitalized in a level I trauma center after TBI.

Design:
Observational cohort study with retrospective (pre-TBI) and prospective (4, 8, and 12 months post-TBI) assessments.

Main measures:

Mini International Neuropsychiatric Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV).

Results:
The percentage of participants using alcohol or drug declined shortly after the injury (4 months) but increased closer to preinjury levels by the end of the first year. Post-TBI alcohol use was higher after mild than moderate/severe TBI, but drug use was similar. About 11% of participants met criteria for a substance use disorder in the first year after TBI. Younger age, not being in a relationship, and suspected substance intoxication at the time of TBI were associated with the presence of a post-TBI substance use disorder.

Conclusion:
Individuals with milder injuries return to alcohol use earlier than those with more severe injuries. Given that substance use may alter recovery, preventive recommendations and systematic follow-ups are warranted regardless of injury severity and access to rehabilitation.
Comorbid Posttraumatic Stress Disorder and Traumatic Brain Injury: Generalization of Prolonged-Exposure PTSD Treatment Outcomes to Postconcussive Symptoms, Cognition, and Self-Efficacy in Veterans and Active Duty Service Members
Authors: Wolf Gregory K. , Mauntel Gregory J. , Kretzmer Tracy , Crawford Eric , Thors Christina , Strom Thad Q. , Vanderploeg Rodney D. 
Published: September 2017

Objectives:
To examine (a) generalization of the effectiveness of prolonged exposure (PE) therapy for posttraumatic stress disorder (PTSD) in improving postconcussive symptoms (PCSs) and other outcomes in military service members and Veterans (VA) with histories of mild to severe traumatic brain injury (TBI), and (b) factors associated with PCS reduction.

Setting:
VA polytrauma medical center.

Participants:
Consecutive referrals for PTSD treatment of Active Duty (n = 17) or Veterans (n = 27) diagnosed with PTSD and TBI (N = 44).

Main Outcome Measures:
Neurobehavioral Symptom Inventory, Key Behaviors Change Inventory, Self-Efficacy for Symptom Management, Posttraumatic Stress Disorder Checklist, and Beck Depression Inventory, 2nd edition.

Design:
Post hoc analysis of archival clinical effectiveness program evaluation data.

Interventions:
PE for PTSD.

Results:
There were significant improvements on all outcome measures with large effect sizes (Cohen's d ranging from 0.68 to 2.02). Improvement on PCS (Cohen's d = 1.21) was associated with lower levels of VA service-connected disability and PE treatment completion.

Conclusion:
PE treatment-related improvements for participants with comorbid PTSD and TBI generalize from PTSD outcomes to PCS and other TBI-related outcomes. Positive outcomes were independent of TBI severity, treatment setting, or Veteran status, but dependent upon PE treatment completion and lower levels of VA service-connected disability.