bluuebunny/crossref_metadata_2025_split huggingface dataset:
Co‐Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia
Authors: Macfarlane Gary J. , Barnish Maxwell S. , Pathan Ejaz , Martin Kathryn R. , Haywood Kirstie L. , Siebert Stefan , Packham Jonathan , Atzeni Fabiola , Jones Gareth T. 
Published: June 2017

ObjectiveTo estimate the proportion of patients with axial spondyloarthritis (SpA) in a UK national biologics registry who met criteria for fibromyalgia (FM), and to delineate the characteristics of these patients.MethodsTwo cohorts of patients are prospectively recruited from across 83 centers in the UK for the British Society for Rheumatology Biologics Register in Ankylosing Spondylitis (BSRBR‐AS). All patients are required to meet Assessment of SpondyloArthritis international Society (ASAS) criteria for axial SpA. Patients are either newly starting biologic therapy (biologics cohort) or are naive to treatment with biologic agents (non‐biologics cohort) at the time of recruitment, and all patients are followed up prospectively. At recruitment and follow‐up, clinical information and measurements are recorded while patients complete the 2011 research criteria for FM and assessments of the level of disease activity and work impact.ResultsOf the patients registered in the BSRBR‐AS, 1,504 (68% male) were eligible for the current analysis, of whom 311 (20.7%) met the 2011 research criteria for FM. Prevalence of FM was similar between patients who fulfilled the modified New York criteria for AS (19.7%) and those who fulfilled ASAS imaging criteria but not the modified New York criteria (25.2%); however, among those who fulfilled only the ASAS clinical criteria, the prevalence of FM was lower (9.5%). Patients who met FM criteria reported significantly worse disease activity, function, global severity scores, and quality of life, and were more likely to have moderate or severe levels of mood disorder and clinically important fatigue. Patients who met FM criteria reported experiencing work impairment around half their working time. Meeting FM criteria was not related to elevated C‐reactive protein levels or most extraspinal manifestations, but was associated with a higher likelihood of having received biologic therapy.ConclusionDeveloping management approaches that would address the significant unmet clinical needs of the 1 in 5 patients with axial SpA who meet criteria for FM should be a research priority.
The prognostic impact of programmed cell death ligand 1 and human leukocyte antigen class I in pancreatic cancer
Authors: Imai Daisuke , Yoshizumi Tomoharu , Okano Shinji , Uchiyama Hideaki , Ikegami Toru , Harimoto Norifumi , Itoh Shinji , Soejima Yuji , Aishima Shinichi , Oda Yoshinao , Maehara Yoshihiko 
Published: June 2017

AbstractPancreatic ductal adenocarcinoma (PDA) is associated with an immunosuppressive tumor‐microenvironment (TME) that supports the growth of tumors and mediates tumors enabling evasion of the immune system. Expression of programmed cell death ligand 1 (PD‐L1) and loss of human leukocyte antigen (HLA) class I on tumor cells are methods by which tumors escape immunosurveillance. We examined immune cell infiltration, the expression of PD‐L1 and HLA class I by PDA cells, and the correlation between these immunological factors and clinical prognosis. PDA samples from 36 patients were analyzed for HLA class I, HLA‐DR, PD‐L1, PD‐1, CD4, CD8, CD56, CD68, and FoxP3 expression by immunohistochemistry. The correlations between the expression of HLA class I, HLA‐DR, PD‐L1 or PD‐1 and the pattern of tumor infiltrating immune cells or the patients’ prognosis were assessed. PD‐L1 expression correlated with tumor infiltration by CD68+ and FoxP3+ cells. Low HLA class I expression was an only risk factor for poor survival. PD‐L1 negative and HLA class I high‐expressing PDA was significantly associated with higher numbers of infiltrating CD8+ T cells in the TME, and a better prognosis. Evaluation of both PD‐L1 and HLA class I expression by PDA may be a good predictor of prognosis for patients. HLA class I expression by tumor cells should be evaluated when selecting PDA patients who may be eligible for treatment with PD‐1/PD‐L1 immune checkpoint blockade therapies.
Synthesis of ZnO Nanoparticles Assisted by N Sources and their Application in the Photodegradation of Organic Contaminants
Authors: da Silva Gelson T. S. T. , Carvalho Kele T. G. , Lopes Osmando F. , Gomes Eliziana S. , Malagutti Andréa R. , Mastelaro Valmor R. , Ribeiro Caue , Mourão Henrique A. J. L. 
Published: June 2017

AbstractA modified polymeric precursor method assisted by N sources (urea or melamine) was used to obtain anion‐doped ZnO nanoparticles. The influence of these molecules on the physical‐chemical and photocatalytic properties of the as‐synthesized samples was investigated. The ZnO nanoparticles exhibited a hexagonal wurtzite phase and crystallite sizes of approximately 20 nm. The addition of urea or melamine to the Zn2+ precursor solution improved the surface properties of the materials and resulted in controlled growth of the N‐doped ZnO nanoparticles, with urea showing superior performance for this purpose. These changes led to improved photocatalytic performance in the degradation of methylene blue (MB) dye and ethionamide antibiotic under UVC irradiation. It was observed that the indirect mechanism involving .OH radical attack played the main role in both photodegradation reactions catalyzed by the as‐synthesized ZnO samples, whereas the photosensitization mechanism had a negligible influence. The use of ESI‐MS analyses showed that the MB dye molecules were broken up by the action of the ZnO photocatalyst, indicating the occurrence of a mineralization process.
Scalable Integration of Highly Uniform MnxCo3−xO4 Nanosheet Array onto Ceramic Monolithic Substrates for Low‐Temperature Propane Oxidation
Authors: Tang Wenxiang , Ren Zheng , Lu Xingxu , Wang Sibo , Guo Yanbing , Hoang Son , Du Shoucheng , Gao Pu‐Xian 
Published: June 2017

AbstractThe redox reaction between KMnO4 and Co(NO3)2 was designed and readily utilized for the scalable integration of spinel MnxCo3−xO4 nanosheet arrays in three‐dimensional ceramic honeycombs by controlling the reaction temperature. The Co2+ can reduce MnO4− to form Mn–Co spinel oxide nanosheet arrays uniformly on the channel surface of cordierite honeycomb. The novel platinum group metal free oxide nanosheet array integrated ceramic honeycomb monolith shows good low‐temperature catalytic activity for propane oxidation, with the 50 % conversion temperature achieved at 310 °C, which is a much lower temperature than that over the wash‐coated commercial Pt/Al2O3. These integrated Mn–Co composite oxide nanoarrays may hold great promise for the construction of advanced monolithic catalyst for high‐performance and low‐cost emission control.
One‐Step Cathodic and Anodic Synthesis of Hydrophilic Carbon Nanomaterials
Authors: Veloso Andreia D. , Botelho do Rego Ana M. , Ferraria Ana M. , Ferreira Luís F. V. , Ferreira Diana P. , Tavares Pedro B. , Videira Romeu , Viana Ana S. , Oliveira M. Cristina 
Published: June 2017

AbstractIt was demonstrated that the galvanostatic polarization of graphite electrodes in a cell with two separated compartments generates simultaneously and straightforwardly, without further separation and functionalization, two distinct sets of hydrophilic carbon nanomaterials [electrogenerated hydrophilic carbon (EHC)], in the anodic and cathodic compartments, respectively. The synthesized products comprise an amorphous carbonaceous material with aromatic sp2 carbon clusters, differing mainly in their oxidation degree. Surprisingly, it was found that nitrogen is incorporated in the carbon‐based material during the electrolysis, which is provided by the N2 gas present in the air and/or aqueous medium. This phenomenon is explained on the basis that very reactive carbonaceous species are formed during the electrodes polarization, owing to an anomalous high electric field generated along the galvanostatic polarization. In addition, it was also evidenced that ECH materials display a negative charge, counterbalanced by sodium ions and unique optical properties, exhibiting deep ultraviolet emission (ca. 4.1 eV), as well as blue luminescence. It is foreseen that these carbon materials will have important repercussions in optoelectronics devices, energy technology (supercapacitors, batteries, and fuel cells), and biomedicine.
Exploring High‐Energy Li‐I(r)on Batteries and Capacitors with Conversion‐Type Fe3O4‐rGO as the Negative Electrode
Authors: Kim Hyun‐Kyung , Aravindan Vanchiappan , Roh Ms. Ha‐Kyung , Lee Kyujoon , Jung Myung‐Hwa , Madhavi Srinivasan , Roh Kwang Chul , Kim Kwang‐Bum 
Published: June 2017

AbstractWe report a microwave‐assisted solvothermal process for the preparation of magnetite (Fe3O4, ca. 5 nm)‐anchored reduced graphene oxide (rGO). It has been examined as a prospective conversion‐type negative electrode for multiple energy storage applications, such as Li‐ion batteries (LIBs) and Li‐ion capacitors (LICs). A LiFePO4/Fe3O4‐rGO cell is constructed and capable of delivering an energy density of approximately 139 Wh kg−1 with a notable cyclability (ca. 76 %) after 500 cycles. Prior to the fabrication of a LIB, the Fe3O4‐rGO is electrochemically pretreated to eliminate the irreversible capacity loss. In addition to the LIB, a high‐energy LIC is also fabricated by using the pre‐lithiated Fe3O4‐rGO composite as the anode and commercial activated carbon as the cathode. This LIC registered a maximum energy density of approximately 114 Wh kg−1 with good cyclability. For both the LIB and LIC, the mass loading between the electrodes was adjusted based on the performance with metallic Li. The improved electrochemical performance of Fe3O4‐rGO over existing materials is a promising development in the quest for novel, fast, low cost, and efficient energy storage systems without compromising the eco‐friendliness
Structural Phase Transitions and Dielectric Switching in a Series of Organic‐Inorganic Hybrid Perovskites ABX3 (X=ClO4− or BF4−)
Authors: Sun Yu‐Ling , Han Xiang‐Bin , Zhang Wen 
Published: June 2017

AbstractA series of organic‐inorganic hybrid perovskites ABX3 (A=diprotonated 1,4‐diazabicyclo[2.2.2]octane or piperazine; B=Na+ or K+; X=ClO4− or BF4−) has been synthesized. They feature a cubic cage‐like host‐guest structures of which A is the cationic guest residing in the anionic cage B8X12, B is the vertex of the cage with variable coordination numbers between six and twelve, and X is the bridging ligand with mono‐ and/or bidentate coordination modes. The extended Goldschmidt tolerance factor t is used to describe the phase stability of the compounds. Differential scanning calorimetry, variable‐temperature structural analyses, and dielectric measurements reveal that order‐disorder transitions of the A guest and/or X bridging ligand are supposed to be responsible for structural phase transitions and dielectric switching in the compounds.
E3M3+ (E=C–Pb, M=Li–Cs) Clusters: The Smallest Molecular Stars
Authors: Contreras Maryel , Pan Sudip , Orozco‐Ic Mesías , Cabellos José Luis , Merino Gabriel 
Published: June 2017

AbstractExtensive potential energy surface explorations of twenty‐five clusters with the formula E3M3+ (E=Group 14 element and M=Group 1 element) through density functional theory and high‐level ab initio computations reveal that the lowest‐energy isomer for all these systems corresponds to a non‐classical D3h star‐like structure in the singlet state, where three M atoms interact electrostatically with the triangular E3 core, occupying three bridging positions around it. More than 18 200 calculations were done in the search for the minima structures, starting with a first phase at the PBE0/LANL2DZ level and ending with an analysis of the most representative clusters at the CCSD(T)/def2‐TZVP//PBE0/def2‐TZVP level. The title clusters represent the smallest molecular stars with three planar tetracoordinate E atoms (E=Group 14 element). All these E3M3+ clusters behave like superalkali cations with small vertical electron affinities (smaller than Cs), large vertical electron detachment energies, and HOMO–LUMO energy gaps. Their energetics, bonding, and electron delocalization are discussed in detail. The high stability of these clusters is reflected from the large dissociation energy needed for different dissociation channels. The electron delocalization is confirmed by the presence of two delocalized π electrons over the E3 core and strong diatropic responses.
Integrative Pericyclic Cascade: An Atom Economic, Multi C−C Bond‐Forming Strategy for the Construction of Molecular Complexity
Authors: Tejedor David , Delgado‐Hernández Samuel , Peyrac Jesús , González‐Platas Javier , García‐Tellado Fernando 
Published: June 2017

AbstractAn all‐pericyclic manifold is developed for the construction of topologically diverse, structurally complex and natural product‐like polycyclic chemotypes. The manifold uses readily accessible tertiary propargyl vinyl ethers as substrates and imidazole as a catalyst to form up to two new rings, three new C−C bonds, six stereogenic centers and one transannular oxo‐bridge. The manifold is efficient, scalable and instrumentally simple to perform and entails a propargyl Claisen rearrangement–[1,3]H shift, an oxa‐6π‐electrocyclization, and an intramolecular Diels–Alder reaction.
Gingival morphology‐controlled design of the complete denture baseplate
Authors: Dai Ning , Yu Xiaoling , Sun Yuchun 
Published: June 2017

AbstractA removable complete denture is still the main selection for edentulous patients. Over the last 5 years, digital technologies for producing complete dentures have rapidly developed. Nevertheless, the design method for the baseplate has become the bottleneck of digital complete denture technology development. In this study, we report a novel method for the generation of esthetic gingiva and polished surfaces of complete dentures that are driven by the feature curve, which can be conveniently modified using the gingival shape factor. A solid modeling method based on Poisson surface reconstruction is used to generate a high‐quality baseplate solid. This method can aid dentists to realize the rapid design process of personalized esthetic baseplate. Finally, the experimental results verify that the method of digital design for the baseplate proposed is efficient and accurate (standard deviation <0.01 mm).
Functional roles of an engineer species for coastal benthic invertebrates and demersal fish
Authors: Chaalali Aurélie , Brind'Amour Anik , Dubois Stanislas F. , Le Bris Hervé 
Published: June 2017

AbstractThrough their tissues or activities, engineer species create, modify, or maintain habitats and alter the distribution and abundance of many plants and animals. This study investigates key ecological functions performed by an engineer species that colonizes coastal ecosystems. The gregarious tubiculous amphipod Haploops nirae is used as a biological model. According to previous studies, the habitat engineered by H. nirae (i.e., Haploops habitat) could provide food and natural shelter for several benthic species such as benthic diatoms belonging to the gender Navicula, the micrograzer Geitodoris planata, or the bivalve Polititapes virgineus. Using data from scientific surveys conducted in two bays, this study explored whether (1) the Haploops sandy‐mud community modifies invertebrate and ichthyologic community structure (diversity and biomass); (2) H. nirae creates a preferential feeding ground; and (3) this habitat serves as a refuge for juvenile fish. Available Benthic Energy Coefficients, coupled with more traditional diversity indices, indicated higher energy available in Haploops habitat than in two nearby habitats (i.e., Sternaspis scutata and Amphiura filiformis/Owenia fusiformis habitats). The use of isotopic functional indices (IFIs) indicated (1) a higher functional richness in the Haploops habitat, related to greater diversity in food sources and longer food chains; and (2) a higher functional divergence, associated with greater consumption of a secondary food source. At the invertebrate‐prey level, IFIs indicated little specialization and little trophic redundancy in the engineered habitat, as expected for homogenous habitats. Our results partly support empirical knowledge about engineered versus nonengineered habitats and also add new perspectives on habitat use by fish and invertebrate species. Our analyses validated the refuge‐area hypothesis for a few fish species. Although unique benthic prey assemblages are associated with Haploops habitat, the hypothesis that it is a preferential feeding area was not verified. However, specialist feeding behavior was observed for predators, which calls for further investigation.
Soil conditioning effects ofPhragmites australison native wetland plant seedling survival
Authors: Crocker Ellen V. , Nelson Eric B. , Blossey Bernd 
Published: June 2017

AbstractInteractions between introduced plants and soils they colonize are central to invasive species success in many systems. Belowground biotic and abiotic changes can influence the success of introduced species as well as their native competitors. All plants alter soil properties after colonization but, in the case of many invasive plant species, it is unclear whether the strength and direction of these soil conditioning effects are due to plant traits, plant origin, or local population characteristics and site conditions in the invaded range.Phragmites australisin North America exists as a mix of populations of different evolutionary origin. Populations of endemic nativePhragmites australis americanusare declining, while introduced European populations are important wetland invaders. We assessed soil conditioning effects of native and non‐nativeP. australispopulations on early and late seedling survival of native and introduced wetland plants. We further used a soil biocide treatment to assess the role of soil fungi on seedling survival. Survival of seedlings in soils colonized byP. australiswas either unaffected or negatively affected; no species showed improved survival inP. australis‐conditioned soils. Population ofP. australiswas a significant factor explaining the response of seedlings, but origin (native or non‐native) was not a significant factor.Synthesis: Our results highlight the importance of phylogenetic control when assessing impacts of invasive species to avoid conflating general plant traits with mechanisms of invasive success. Both native (noninvasive) and non‐native (invasive)P. australispopulations reduced seedling survival of competing plant species. Because soil legacy effects of native and non‐nativeP. australisare similar, this study suggests that the close phylogenetic relationship between the two populations, and not the invasive status of introducedP. australis, is more relevant to their soil‐mediated impact on other plant species.
The relationship between male sexual signals, cognitive performance, and mating success in stickleback fish
Authors: Minter Ross , Keagy Jason , Tinghitella Robin M. 
Published: June 2017

AbstractCognitive ability varies dramatically among individuals, yet the manner in which this variation correlates with reproduction has rarely been investigated. Here, we ask (1) do male sexual signals reflect their cognitive ability, and (2) is cognitive ability associated with male mating success? Specifically, we presented threespine sticklebacks (Gasterosteus aculeatus) with a detour‐reaching task to assess initial inhibitory control. Fish that performed better were those who solved the detour‐reaching task, solved it faster, and required fewer attempts to solve. We then reexamined males’ performance on this task over several days to assess learning ability in this context. We next measured sexual signals (coloration, nest area, and courtship vigor) and asked whether they reveal information about these male cognitive abilities. Finally, we examined whether success at attracting a female is associated with male cognition. After controlling for the strong effect of neophobia, we found that no measured sexual signals were associated with initial inhibitory control. Sexual signals were also not associated with change in performance on the detour‐reaching task over time (learning). However, females preferred mating with males who had better initial inhibitory control. We speculate that inhibitory control is a critical trait for male sticklebacks. In this system, males perform all parental care, but must avoid eating their own fry which closely resemble their prey items. Therefore, males with better inhibitory control may be more likely to successfully raise their offspring to independence. Our research adds to a growing list of mating systems and taxa in which cognition is important for measures related to fitness.
Exploiting opportunistic observations to estimate changes in seasonal site use: An example with wetland birds
Authors: Ruete Alejandro , Pärt Tomas , Berg Åke , Knape Jonas 
Published: June 2017

AbstractNonsystematically collected, a.k.a. opportunistic, species observations are accumulating at a high rate in biodiversity databases. Occupancy models have arisen as the main tool to reduce effects of limited knowledge about effort in analyses of opportunistic data. These models are generally using long closure periods (e.g., breeding season) for the estimation of probability of detection and occurrence. Here, we use the fact that multiple opportunistic observations in biodiversity databases may be available even within days (e.g., at popular birding localities) to reduce the closure period to 1 day in order to estimate daily occupancies within the breeding season. We use a hierarchical dynamic occupancy model for daily visits to analyze opportunistic observations of 71 species from nine wetlands during 10 years. Our model derives measures of seasonal site use within seasons from estimates of daily occupancy. Comparing results from our “seasonal site use model” to results from a traditional annual occupancy model (using a closure criterion of 2 months or more) showed that our model provides more detailed biologically relevant information. For example, when the aim is to analyze occurrences of breeding species, an annual occupancy model will over‐estimate site use of species with temporary occurrences (e.g., migrants passing by, single itinerary prospecting individuals) as even a single observation during the closure period will be viewed as an occupancy. Alternatively, our model produces estimates of the extent to which sites are actually used. Model validation based on simulated data confirmed that our model is robust to changes and variability in sampling effort and species detectability. We conclude that more information can be gained from opportunistic data with multiple replicates (e.g., several reports per day almost every day) by reducing the time window of the closure criterion to acquire estimates of occupancies within seasons.