bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of social camouflaging in autistic adults and youth: Implications and theory
Authors: Klein Jessica , Krahn Rachel , Howe Stephanie , Lewis Jessi , McMorris Carly , Macoun Sarah 
Published: October 2024

Abstract
Social camouflaging (SC) is a set of behaviors used by autistic people to assimilate with their social environment. Using SC behaviours may put autistic people at risk for poor mental health outcomes. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the goal of this systematic review was to investigate the development of SC and inform theory in this area by outlining the predictors, phenotype, and consequences of SC. This review fills a gap in existing literature by integrating quantitative and qualitative methodologies, including all gender identities/age groups of autistic individuals, incorporating a large scope of associated factors with SC, and expanding on theory/implications. Papers were sourced using Medline, PsycInfo, and ERIC. Results indicate that self-protection and desire for social connection motivate SC. Camouflaging behaviors include compensation, masking, and assimilation. Female individuals were found to be more likely to SC. Additionally, this review yielded novel insights including contextual factors of SC, interpersonal relational and identity-related consequences of SC, and possible bidirectional associations between SC and mental health, cognition, and age of diagnosis. Autistic youth and adults have similar SC motivations, outward expression of SC behavior, and experience similar consequences post-camouflaging. Further empirical exploration is needed to investigate the directionality between predictors and consequences of SC, and possible mitigating factors such as social stigma and gender identity.
Usefulness of percutaneous transluminal coronary balloon angioplasty for coronary artery stenosis after surgery for CHD
Authors: Tsuda Etsuko , Kitano Masataka , Iwasa Toru , Sakaguchi Heima , Ohuchi Hideo , Kurosaki Kenichi 
Published: October 2024

AbstractCoronary artery involvements occur rarely both during cardiac repair and in the late period after surgery, and it may result in myocardial ischaemia and infarction. We present six cases who underwent percutaneous transluminal coronary balloon angioplasty for coronary artery stenosis in the late period after surgery. The patients included four boys and two girls. Post-operative states involving anomalous origin of the left coronary artery from the pulmonary artery and d-transposition of the great arteries were observed in two patients each. Two patients with univentricular heart had coronary artery injuries during surgery. The age at the angioplasty ranged from 1 month to 14 years, with a median of 3 years. The interval from the operation to angioplasty ranged from 37 days to 14 years (median 8 months). The interval from the angioplasty to follow-up coronary angiography ranged from 2 months to 14 years (median 11 months). The follow-up period ranged from 2 months to 20 years (median 8 years). One patient underwent a stent implantation because of post-procedure recoil. Coronary artery stenosis improved immediately after procedure in the six patients without complication, and restenosis occurred post-procedure in one patient. Five patients had no cardiac events. Although the angioplasty’s initial effect may not be dramatic, it can improve late after the procedure. It was considered that the optimal balloon-reference vessel ratio to obtain a minimal effective lumen diameter was about 1.0. Angioplasty post-surgery for CHD in children was feasible and without complications.
Divisia monetary aggregates, monetary policy and business cycle analysis
Authors: Raghavan Mala 
Published: October 2024

Abstract
The paper builds a parsimonious US business cycle SVARMA model, establishing identification conditions for independent monetary shocks. The SVARMA model, utilizing Divisia M3 and Divisia M4, is compared to the simple sum M2. The monetary rule with Divisia M3 yields theoretically consistent results marked by the absence of the usual price and liquidity puzzles. As the Federal Reserve (Fed) took a more hawkish approach to curb inflation, significant increases in US interest rates and declines in monetary aggregates were largely influenced by the Fed’s reaction function, which incorporates the Divisia M3 monetary rule. Findings emphasize the monetary impact on the business cycle, highlighting the significance of Divisia monetary aggregates. Historical and variance decompositions reveal diverse, dynamic effects of monetary shocks on macroeconomic variables. The SVARMA model with Divisia M3 and M4 demonstrates superior performance over simple sum M2 in capturing the time path of monetary shocks.
Subsurface Temperature Anomalies Off Central Oregon During 2014–2021
Authors: Cervantes Brandy T. , Fewings Melanie R. , Risien Craig M. 
Published: October 2024

AbstractWe use moored observations in 80 m water depth at the NH‐10 site along the historic Newport Hydrographic Line from 1999 to 2021 to calculate water temperature anomalies at the surface, near surface, and bottom. Analysis is focused on the subsurface temporal and spatial characteristics of marine heatwaves (MHWs) during 2014–2016 and 2019–2020 on the continental shelf and slope. Warm anomalies extend throughout the water column in fall/winter 2014–2016 when winds are predominantly downwelling‐favorable, while the 2019–2020 period is characterized by shallower summer and fall anomalies on the shelf. Sustained temperature anomalies during the bottom MHW in late 2016 are the largest in the NH‐10 time series. Analysis of temporal patterns in wind stress during MHW and non‐MHW periods shows the onset of upwelling‐favorable winds interrupts warm events. Indices of cumulative upwelling and annual spring transition dates reveal the spring transition was unusually late in 2014, with only five years with later spring transitions since the upwelling index record began in 1967. In 2015 and 2019, in contrast, spring transition is close to the climatological mean of April 15. In 2016 and 2020, anomalous warming is observed when cumulative upwelling decreases after an early spring transition.
A Framework for Assessing Ocean Mixed Layer Depth Evolution
Authors: Legay Alexandre , Deremble Bruno , Penduff Thierry , Brasseur Pierre , Molines Jean‐Marc 
Published: October 2024

AbstractThe ocean surface mixed layer plays a crucial role as an entry or exit point for heat, salt, momentum, and nutrients from the surface to the deep ocean. In this study, we introduce a framework to assess the evolution of the mixed layer depth (MLD) for realistic forcings and preconditioning conditions. Our approach involves a physically‐based parameter space defined by three dimensionless numbers: λs representing the relative contribution of the buoyancy flux and the wind stress at the air‐sea interface, Rh the Richardson number which characterizes the stability of the water column relative to the wind shear, and f/Nh which characterizes the importance of the Earth's rotation (ratio of the Coriolis frequency f and the pycnocline stratification Nh). Four MLD evolution regimes (“restratification,” “stable,” “deepening,” and “strong deepening”) are defined based on the values of the normalized temporal evolution of the MLD. We evaluate the 3D parameter space in the context of 1D simulations and we find that considering only the two dimensions (λs, Rh) is the best choice of 2D projection of this 3D parameter space. We then demonstrate the utility of this two‐dimensional λs − Rh parameter space to compare 3D realistic ocean simulations: we discuss the impact of the horizontal resolution (1°, 1/12°, or 1/60°) and the Gent‐McWilliams parameterization on MLD evolution regimes. Finally, a proof of concept of using observational data as a truth indicates how the parameter space could be used for model calibration.
Biodiversity Conservation Strategies From No Net Loss to Net Gain. A Multidimensional Accounting Method
Authors: Yan Ningyu , Liu Gengyuan , Ulgiati Sergio , Yang Zhifeng 
Published: October 2024

AbstractBiodiversity credits are increasingly recognized as a potential instrument to incentivize and bolster efforts in biodiversity conservation. Nevertheless, their efficacy is impeded by a dearth of research. To mitigate these constraints, this study introduces a comprehensive and integrated framework for appraising biodiversity credits. Drawing upon the Emergy Accounting methodology, the framework encompasses four key perspectives: Emergy‐based Ecosystem Potential (EEP), Emergy‐based Ecosystem Network (EEN), Emergy‐based “Species' to Human” contributions (ESH), and Emergy‐based Species' Significance. Furthermore, this study scrutinizes the trajectory of biodiversity credits across 31 provinces spanning from 2000 to 2050, considering 220 distinct scenarios. The findings reveal that China has attained the no net loss (NNL) objective concerning conventional area‐based conservation targets, with forest cover encompassing 27% of the total land area. However, biodiversity credits at the ecosystem level exhibit an escalating trend, with growth rates ranging from 0.73% to 1.0%, while credits at the species level depict a decremental trend, with an approximate growth rate of −0.21%. Under a scenario of moderate growth, projections for the year 2030 indicate that the EEP credit is poised to accrue approximately 4.76E + 20 solar emjoules (sej), the EEN credit is forecasted to accumulate around 1.03E + 21 sej, and the ESH credit is anticipated to decline by 1.46E + 23 sej within the context of the NNL paradigm. These outcomes underscore the necessity of delineating differentiated biodiversity goals, and furnish insights into the dynamics of supply and demand pertaining to biodiversity credits within the ambit of offsetting schemes across the nation.
Competing Phases of Iron at Earth's Core Conditions From Deep‐Learning‐Aided ab‐initio Simulations
Authors: Li Zhi , Scandolo Sandro 
Published: October 2024

AbstractThe properties and relative stability of different structures of iron at the extreme conditions of pressure and temperature of relevance for the Earth's core were determined with ab‐initio atomistic simulations aided by a machine‐learning force‐field. We find that the body‐centered cubic (bcc) structure is mechanically stable at core temperatures, but its free energy is marginally higher than those of the hexagonal close‐packed and face‐centered cubic structures. The bcc structure is the only structure whose shear sound velocity matches seismic data. The small free‐energy difference between competing structures suggests that the role of impurities could be crucial in stabilizing the bcc structure in the inner core.
The Rapid Response of Southern Ocean Biological Productivity to Changes in Background Small Scale Turbulence
Authors: Ellison E. , Mazloff M. , Mashayek A. 
Published: October 2024

AbstractBackground subsurface vertical mixing rates in the Southern Ocean (SO) are known to vary by an order of magnitude temporally and spatially, due to variability in their generating mechanisms, which include winds and shear instabilities at the surface, and the interaction of tides and lee waves with rough bottom topography. There is great uncertainty in the parameterization of this mixing in coarse resolution Earth System Models (ESM), and in the impact that this has on SO biological productivity on sub decadal timescales. Using a data assimilating biogeochemical ocean model we show that SO phytoplankton productivity is highly sensitive to differences in background diapycnal mixing over short timescales. Changes in the background vertical mixing rates alter key biogeochemical and physical conditions. The greatest changes to the distribution of physical and biogeochemical tracers occur in regions with very strong tracer vertical gradients. A combination of reduced nutrient limitation and reduced light limitation causes a strong increase in SO phytoplankton productivity with higher background mixing. This leads to increased summer carbon export but reduced wintertime export over the mixed layer depth, which could alter the strength of the SO biological carbon pump and atmospheric concentrations on centennial to millennial timescales. This study demonstrates the importance of accurately representing diapycnal mixing in ESM to predict SO biogeochemical dynamics and their broader climatic implications.
Premelting Theory‐Based Mechanism for Water Freezing in Saline Soil
Authors: Wan Xusheng , Zhu Jishuai , Lai Ying , Lu Jianguo , Yan Zhongrui 
Published: October 2024

AbstractThe unfrozen water content constitutes a pivotal parameter in freezing soil, significantly impacting its thermal‐mechanical and deformation behavior. This study delves into the alterations in soil attributes as unfrozen water content varies. It examines the influences of impurities, van der Waals forces, and Coulomb forces on the water film, employing the premelting theory as a foundation. A critical state curve quantifying the ratio of the surface charge density to impurity concentration is parameterized for various soil types. Subsequently, combining the theory of effective solution concentration, we have provided calculation methods for the particle surface parameters of pore solutions as ideal and non‐ideal dilute solutions, respectively. This has determined the key variables in the model. Additionally, through the integration of equivalent particle sizes, packing structure, and water film thickness, a calculation model is devised and verified for determining the unfrozen water content and residual water content within in freezing soil. The findings indicate that fluctuation in the unfrozen water content primarily stem from impurities. In soils with equivalent saline content, impurity levels exhibit proportionality to the equivalent particle sizes. The residual unfrozen water is predominantly present within the absorbed water layer.
Secreted nucleases reclaim extracellular DNA during biofilm development
Authors: Lander Stephen M. , Fisher Garth , Everett Blake A. , Tran Peter , Prindle Arthur 
Published: October 2024

AbstractDNA is the genetic code found inside all living cells and its molecular stability can also be utilized outside the cell. While extracellular DNA (eDNA) has been identified as a structural polymer in bacterial biofilms, whether it persists stably throughout development remains unclear. Here, we report that eDNA is temporarily invested in the biofilm matrix before being reclaimed later in development. Specifically, by imaging eDNA dynamics within undomesticated Bacillus subtilis biofilms, we found eDNA is produced during biofilm establishment before being globally degraded in a spatiotemporally coordinated pulse. We identified YhcR, a secreted Ca2+-dependent nuclease, as responsible for eDNA degradation in pellicle biofilms. YhcR cooperates with two other nucleases, NucA and NucB, to reclaim eDNA for its phosphate content in colony biofilms. Our results identify extracellular nucleases that are crucial for eDNA reclamation during biofilm development and we therefore propose a new role for eDNA as a dynamic metabolic reservoir.
Haplotype-resolved and near-T2T genome assembly of the African catfish (Clarias gariepinus)
Authors: Nguinkal Julien A. , Zoclanclounon Yedomon A. B. , Brunner Ronald M. , Chen Yutang , Goldammer Tom 
Published: October 2024

AbstractAirbreathing catfish are stenohaline freshwater fish capable of withstanding various environmental conditions and farming practices, including breathing atmospheric oxygen. This unique ability has enabled them to thrive in semi-terrestrial habitats. However, the genomic mechanisms underlying their adaptation to adverse ecological environments remain largely unexplored, primarily due to the limited availability of high-quality genomic resources. Here, we present a haplotype-resolved and near telomere-to-telomere (T2T) genome assembly of the African catfish (Clarias gariepinus), utilizing Oxford Nanopore, PacBio HiFi, Illumina and Hi-C sequencing technologies. The primary assembly spans 969.62 Mb with only 47 contigs, achieving a contig N50 of 33.71 Mb. Terminal telomeric signals were detected in 22 of 47 contigs, suggesting T2T assembled chromosomes. BUSCO analysis confirmed gene space completeness of 99% against the Actinopterygii dataset, highlighting the high quality of the assembly. Genome annotation identified 25,655 protein-coding genes and estimated 43.94% genome-wide repetitive elements. This data provides valuable genomic resources to advance aquaculture practices and to explore the genomic underpinnings of the ecological resilience of airbreathing catfish and related teleosts.
Similarities of metabolomic disturbances in prematurity-associated obstructive lung disease to chronic obstructive pulmonary disease
Authors: Course Christopher W. , Lewis Philip A. , Kotecha Sarah J. , Cousins Michael , Hart Kylie , Heesom Kate J. , Watkins W. John , Kotecha Sailesh 
Published: October 2024

AbstractPrematurity-associated lung disease (PLD) is a long-term consequence of preterm-birth. Since the underlying mechanisms of PLD remain poorly characterised, we compared the urinary metabolome between recently described spirometry phenotypes of PLD. Preterm- and term-born children aged 7–12 years, from the Respiratory Health Outcomes in Neonates (RHiNO) cohort, underwent spirometry and urine collection. The urinary metabolome was analysed by gas chromatography time-of-flight mass spectrometry. Preterm-born children were classified into phenotypes of prematurity-associated obstructive lung disease (POLD, Forced expiratory volume in 1 s (FEV1) < lower limit of normal (LLN), FEV1/Forced Vital Capacity (FVC) < LLN), prematurity-associated preserved ratio impaired spirometry (pPRISm, FEV1 < LLN, FEV1/FVC ≥ LLN) and Preterm/Term controls (FEV1 ≥ LLN). Metabolite set enrichment analysis was used to link significantly altered metabolites between the groups with metabolic pathways. Univariable and multivariable linear regression models examined associations between early and current life factors and significantly altered metabolites of interest. Urine from 197 preterm- and 94 term-born children was analysed. 23 and 25 were classified into POLD and pPRISm groups respectively. Of 242 identified metabolites, 49 metabolites were significantly altered in the POLD group compared with Preterm controls. Decreased capric acid (log2 fold change − 0.23; p = 0.003), caprylic acid (− 0.18; 0.003) and ceratinic acid (− 0.64; 0.014) in the POLD group, when compared to preterm controls, were linked with reduced β-oxidation of very long chain fatty acids (p = 0.004). Reduced alanine (log2 fold change − 0.21; p = 0.046), glutamic acid (− 0.24; 0.023), and pyroglutamic acid (− 0.17; 0.035) were linked with decreased glutathione metabolism (p = 0.008). These metabolites remained significantly associated with POLD in multivariable models adjusting for early/current life factors. The pPRISm urinary metabolome was minimally changed when compared with preterm-born controls. When compared to term-born subjects, alterations in tryptophan metabolism were implicated (p = 0.01). The urinary metabolome in POLD showed significantly altered β-oxidation of fatty acids and glutathione metabolism, implying alterations in cellular metabolism and oxidative stress. Similar findings have been noted in adults with chronic obstructive pulmonary disease. Given the similarity of findings between the POLD group and those reported for COPD, the POLD group should be considered at future risk of developing COPD.
TRPC5 controls the adrenaline-mediated counter regulation of hypoglycemia
Authors: Bröker-Lai Jenny , Rego Terol José , Richter Christin , Mathar Ilka , Wirth Angela , Kopf Stefan , Moreno-Pérez Ana , Büttner Michael , Tan Linette Liqi , Makke Mazen , Poschet Gernot , Hermann Julia , Tsvilovskyy Volodymyr , Haberkorn Uwe , Wartenberg Philipp , Susperreguy Sebastian , Berlin Michael , Ottenheijm Roger , Philippaert Koenraad , Wu Moya , Wiedemann Tobias , Herzig Stephan , Belkacemi Anouar , Levinson Rebecca T , Agarwal Nitin , Camacho Londoño Juan E , Klebl Bert , Dinkel Klaus , Zufall Frank , Nussbaumer Peter , Boehm Ulrich , Hell Rüdiger , Nawroth Peter , Birnbaumer Lutz , Leinders-Zufall Trese , Kuner Rohini , Zorn Markus , Bruns Dieter , Schwarz Yvonne , Freichel Marc 
Published: October 2024

AbstractHypoglycemia triggers autonomic and endocrine counter-regulatory responses to restore glucose homeostasis, a response that is impaired in patients with diabetes and its long-term complication hypoglycemia-associated autonomic failure (HAAF). We show that insulin-evoked hypoglycemia is severely aggravated in mice lacking the cation channel proteins TRPC1, TRPC4, TRPC5, and TRPC6, which cannot be explained by alterations in glucagon or glucocorticoid action. By using various TRPC compound knockout mouse lines, we pinpointed the failure in sympathetic counter-regulation to the lack of the TRPC5 channel subtype in adrenal chromaffin cells, which prevents proper adrenaline rise in blood plasma. Using electrophysiological analyses, we delineate a previously unknown signaling pathway in which stimulation of PAC1 or muscarinic receptors activates TRPC5 channels in a phospholipase-C-dependent manner to induce sustained adrenaline secretion as a crucial step in the sympathetic counter response to insulin-induced hypoglycemia. By comparing metabolites in the plasma, we identified reduced taurine levels after hypoglycemia induction as a commonality in TRPC5-deficient mice and HAAF patients.
Alternative splicing of PBRM1 mediates resistance to PD-1 blockade therapy in renal cancer
Authors: Cho Namjoon , Kim Seung-Yeon , Lee Sung-Gwon , Park Chungoo , Choi Sunkyung , Kim Eun-Mi , Kim Kee K 
Published: October 2024

AbstractAlternative pre-mRNA splicing (AS) is a biological process that results in proteomic diversity. However, implications of AS alterations in cancer remain poorly understood. Herein, we performed a comprehensive AS analysis in cancer driver gene transcripts across fifteen cancer types and found global alterations in inclusion rates of the PBAF SWI/SNF chromatin remodeling complex subunit Polybromo 1 (PBRM1) exon 27 (E27) in most types of cancer tissues compared with those in normal tissues. Further analysis confirmed that PBRM1 E27 is excluded by the direct binding of RBFOX2 to intronic UGCAUG elements. In addition, the E27-included PBRM1 isoform upregulated PD-L1 expression via enhanced PBAF complex recruitment to the PD-L1 promoter. PBRM1 wild-type patients with clear cell renal cell carcinoma were resistant to PD-1 blockade therapy when they expressed low RBFOX2 mRNA levels. Overall, our study suggests targeting of RBFOX2-mediated AS of PBRM1 as a potential therapeutic strategy for immune checkpoint blockade.
O-GlcNAcylation of circadian clock protein Bmal1 impairs cognitive function in diabetic mice
Authors: Hui Ya , Zhong Yuanmei , Kuang Liuyu , Xu Jingxi , Hao Yuqi , Cao Jingxue , Zheng Tianpeng 
Published: October 2024

AbstractNeuronal damage in the hippocampus induced by high glucose has been shown to promote the onset and development of cognitive impairment in diabetes, but the underlying molecular mechanism remains unclear. Guided by single-cell RNA sequencing, we here report that high glucose increases O-GlcNAcylation of Bmal1 in hippocampal neurons. This glycosylation promotes the binding of Clock to Bmal1, resulting in the expression of transcription factor Bhlhe41 and its target Dnajb4. Upregulated Dnajb4 in turn leads to ubiquitination and degradation of the mitochondrial Na + /Ca2+ exchanger NCLX, thereby inducing mitochondrial calcium overload that causes neuronal damage and cognitive impairment in mice. Notably, Bhlhe41 downregulation or treatment with a short peptide that specifically blocks O-GlcNAcylation of Bmal1 on Ser424 mitigated these adverse effects in diabetic mouse models. These data highlight the crucial role of O-GlcNAcylation in circadian clock gene expression and may facilitate the design of targeted therapies for diabetes-associated cognitive impairment.