bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Journal-Level Analysis of Progress in Transplantation
Authors: Feeley Thomas , Lee Seyoung , Moon Shin-Il 
Published: December 2017

Context: Citations to articles published in academic journals represent a proxy for influence in bibliometrics. Objective: To measure the journal impact factor for Progress in Transplantation over time and to also identify related journals indexed in transplantation and surgery. Design: Data from Journal Citation Reports (ISI web of science) were used to rank Progress in Transplantation compared to peer journals using journal impact and journal relatedness measures. Social network analysis was used to measure relationships between pairs of journals in Progress in Transplantation’s relatedness network. Main Outcome Measures: Journal impact factor and journal relatedness. Results: Data from 2010 through 2015 indicate the average journal article in PIT was cited 0.87 times (standard deviation [SD] = 0.12) and this estimate was stable over time. Progress in Transplantation most often cited American Journal of Transplantation, Transplantation, American Journal of Kidney Diseases, and Liver Transplantation. In terms of cited data, the journal was most often referenced by Clinical Transplantation, Transplant International, and Current Opinion in Organ Transplantation. Conclusion: The journal is listed both in surgery and transplantation categories of Journal Citation Reports and its impact factors over time fare better with surgery journals than with transplant journals. Network data using betweenness centrality indicate Progress in Transplantation links transplantation-focused journals and journals indexed in health sciences categories.
Ethics and practice of Trials within Cohorts: An emerging pragmatic trial design
Authors: Kim Scott YH , Flory James , Relton Clare 
Published: December 2017

Background: With increasing emphasis on pragmatic trials, new randomized clinical trial designs are being proposed to enhance the “real world” nature of the data generated. We describe one such design, appropriate for unmasked pragmatic clinical trials in which the control arm receives usual care, called “Trials within Cohorts” that is increasingly used in various countries because of its efficiency in recruitment, advantages in reducing subject burden, and ability to better mimic real-world consent processes. Methods: Descriptive, ethical, and US regulatory analysis of the Trials within Cohorts design. Results: Trials within Cohorts design involves, after recruitment into a cohort, randomization of eligible subjects, followed by an asymmetric treatment of the two arms: those selected for the experimental arm provide informed consent for the intervention trial, while the data from the control arm are used based on prior broad permission. Thus, unlike the traditional Zelen post-randomization consent design, the cohort participants are informed about future research within the cohort; however, the extent of this disclosure currently varies among studies. Thus, ethical analysis is provided for two types of situations: when the pre-randomization disclosure and consent regarding the embedded trials are fairly explicit and detailed versus when they consist of only general statements about future data use. These differing ethical situations could have implications for how ethics review committees apply US research rules regarding waivers and alterations of informed consent. Conclusion: Trials within Cohorts is a promising new pragmatic randomized controlled trial design that is being increasingly used in various countries. Although the asymmetric consent procedures for the experimental versus control arm subjects can initially raise ethical concerns, it is ethically superior to previous post-randomization consent designs and can have important advantages over traditional trial designs.
Rotator cuff disorders: a survey of current (2016) UK physiotherapy practice
Authors: Bury Julie , Littlewood Chris 
Published: December 2017

Background Shoulder pain is a common musculoskeletal presentation, with disorders of the rotator cuff (RC) regarded as the most frequent cause. Conservative treatment is often the initial management; however, findings from a previous survey showed considerable variations in clinical practice, including the use of modalities that are not supported in the literature, suggesting that research is not impacting on practice. The present study aimed to survey current UK physiotherapy practice for the management of RC disorders and to determine whether this has changed over the 5-year period since the last survey was conducted. Methods A cross-sectional online survey of UK physiotherapists was conducted. Results One hundred and ninety-one respondents completed the survey which showed that advice/education and some form of exercise therapy are most commonly used as a management strategy for RC disorders. There is a lack of agreement however regarding exercise prescription. The survey suggests less use of passive modalities, indicating that practice has advanced over the last 5 years in line with the current evidence. Conclusions The present study has highlighted that the clinical practice of the survey respondents was in line with current recommendations from research. Hence, in contrast to the survey conducted 5 years previously, research appears to be impacting on practice, which is a positive finding.
Impact of an antifungal stewardship intervention on optimization of candidemia management
Authors: Rac Hana , Wagner Jamie L. , King S. Travis , Barber Katie E. , Stover Kayla R. 
Published: December 2017

Background: Candidemia represents a leading cause of healthcare-associated bloodstream infections with significant morbidity and mortality. Previous studies have demonstrated that comprehensive care bundles improve candidemia management but are time-consuming. Objective: To determine the impact of a one-time targeted candidemia intervention on time to initiation of adequate therapy compared to standard of care. Methods: This Institutional Review Board (IRB)-approved, quasi-experiment evaluated a targeted candidemia intervention involving a single phone call to the primary team providing recommendations for care. Daily follow-up was provided by the infectious diseases (ID) consult service. Two time periods were evaluated: pre-intervention (01 August 2012 to 31 July 2014) and post-intervention (01 October 2014 to 30 September 2016). The primary endpoint was time to adequate antifungal therapy (TTx) in the business hours (6 a.m. to 6 p.m. Monday through Friday) population (BHP). Secondary endpoints were TTx in the total population as well as infection-related length of stay (IF-LOS) and compliance with quality indicators (composite endpoint: ophthalmology (OPH) consult, repeat cultures, and ⩾14 days of adequate therapy). Results: In all, 117 patients were included (pre-intervention = 50, post-intervention = 67, BHP = 51). TTx decreased from 2 h 57 m to 2 h 12 m ( p = 0.094) in the BHP and 3 h 30 m to 2 h 9 m ( p = 0.021) in the total population. There was no difference in IF-LOS ( p = 0.797), compliance with quality indicators ( p = 0.343), or in-hospital mortality ( p = 0.761). Post-intervention, there were more ID and OPH consults ( p < 0.001). Conclusions: Our one-time candidemia intervention did not statistically decrease time to adequate therapy in the BHP, but did in the total population. No differences were found for other clinical outcomes, except increases in ID and OPH consults. Further studies are needed to examine whether a one-time intervention is non-inferior to a more comprehensive care bundle.
Vitamin D toxicity of dietary origin in cats fed a natural complementary kitten food
Authors: Crossley Victoria J , Bovens Catherine PV , Pineda Carmen , Hibbert Angie , Finch Natalie C 
Published: December 2017

Case series summary This case series describes two young sibling cats and an additional unrelated cat, from two separate households, that developed hypercalcaemia associated with hypervitaminosis D. Excessive vitamin D concentrations were identified in a natural complementary tinned kitten food that was fed to all three cats as part of their diet. In one of the cases, there was clinical evidence of soft tissue mineralisation. The hypercalcaemia and soft tissue mineralisation resolved following withdrawal of the affected food and medical management of the hypercalcaemia. Relevance and novel information This case series demonstrates the importance of obtaining a thorough dietary history in patients presenting with hypercalcaemia and the measurement of vitamin D metabolites when investigating such cases. Complementary foods may have the potential to induce nutritional toxicity even when fed with complete, nutritionally balanced diets.
Antihypertensive treatment with telmisartan in a cat with amlodipine-induced gingival hyperplasia
Authors: Desmet Lien , van der Meer Jeroen 
Published: December 2017

Case summary Systemic arterial hypertension is commonly reported in middle-aged-to-older cats. Amlodipine is recommended as the initial antihypertensive drug in cats. In this case report, gingival hyperplasia secondary to the use of amlodipine in a cat is described. Benazepril as a monotherapy was unsuccessful in reducing blood pressure in this cat. After replacement of benazepril by telmisartan, gingival hyperplasia disappeared and blood pressure was well controlled. Relevance and novel information This case report describes the first reported case of reversible gingival hyperplasia as a result of the treatment with amlodipine. It also contains the first published data on the effect of telmisartan in a hypertensive cat.
Quantitative Assessment of the Anatomical Footprint of the C1 Pedicle Relative to the Lateral Mass: A Guide for C1 Lateral Mass Fixation
Authors: Su Brian W. , Theologis Alexander A. , Byers Robert H. , Shimer Adam L. , Schroeder Gregory D. , Vaccaro Alexander R. , Tay Bobby 
Published: December 2017

Study Design: Anatomic study. Objectives: To determine the relationship of the anatomical footprint of the C1 pedicle relative to the lateral mass (LM). Methods: Anatomic measurements were made on fresh frozen human cadaveric C1 specimens: pedicle width/height, LM width/height (minimum/maximum), LM depth, distance between LM’s medial aspect and pedicle’s medial border, distance between LM’s lateral aspect to pedicle’s lateral border, distance between pedicle’s inferior aspect and LM’s inferior border, distance between arch’s midline and pedicle’s medial border. The percentage of LM medial to the pedicle and the distance from the center of the LM to the pedicle’s medial wall were calculated. Results: A total of 42 LM were analyzed. The C1 pedicle’s lateral aspect was nearly confluent with the LM’s lateral border. Average pedicle width was 9.0 ± 1.1 mm, and average pedicle height was 5.0 ± 1.1 mm. Average LM width and depth were 17.0 ± 1.6 and 17.2 ± 1.6 mm, respectively. There was 6.9 ± 1.5 mm of bone medial to the medial C1 pedicle, which constituted 41% ± 9% of the LM’s width. The distance from C1 arch’s midline to the medial pedicle was 13.5 ± 2.0 mm. The LM’s center was 1.6 ± 1 mm lateral to the medial pedicle wall. There was on average 3.5 ± 0.6 mm of the LM inferior to the pedicle inferior border. Conclusions: The center of the lateral mass is 1.6 ± 1 mm lateral to the medial wall of the C1 pedicle and approximately 15 mm from the midline. There is 6.9 ± 1.5 mm of bone medial to the medial C1 pedicle. Thus, the medial aspect of C1 pedicle may be used as an anatomic reference for locating the center of the C1 LM for screw fixation.
Lived Experiences of Adolescent Athletes Following Sport-Related Concussion
Authors: Valovich McLeod Tamara C. , Wagner Alyssa J. , Bacon Cailee E. Welch 
Published: December 2017

Background: Previous studies have identified the effect of sport-related concussion on health-related quality of life through the use of patient-reported outcome measures. However, there has been little research exploring the underlying mechanisms that influence these perceptions of health-related quality of life among adolescent athletes who have sustained a sport-related concussion. Purpose: To explore the psychosocial aspects of concussion among adolescent athletes. Study Design: Case series; Level of evidence, 4. Methods: A total of 12 interscholastic athletes (4 girls, 8 boys; mean ± SD age, 15.7 ± 1.7 years; grade level, 10.2 ± 1.4) were interviewed via a semistructured interview protocol between 15 and 30 days postinjury. Data analysis was guided by the consensual qualitative research tradition. Themes and categories emerged through consensus by a 3-person research team, and bias was minimized through the use of multiple-analyst triangulation. Results: Participants identified numerous postconcussion symptoms that resulted in increasing difficulty with emotions (eg, irritable, easily frustrated), roles at school (eg, concentration difficulties, fatigue), and roles in their social environment (eg, letting the team down, not being able to contribute to sport). As a result, participants expressed how they tried to minimize or mask symptoms to decrease the potential of being viewed differently by their peers. Conclusion: Adolescent athletes perceived a significant effect of sport-related concussion on numerous areas of psychosocial and emotional health and well-being. Anticipatory guidance—with education regarding the possible signs and symptoms, risk factors, and recovery expectations following a concussion—is important to include in postinjury management. A better understanding of sport-related concussion and expected recovery could help to improve perceptions of this injury among interscholastic athletes. Additionally, best practices should be identified to assist health care professionals and school personnel in the development of temporary adjustments or formal academic adjustment policies in the secondary school setting, therefore ensuring that the patients receive the support that they need to maintain their roles as students.
‘Precolonial Studies’: Emily Erikson on the English East India Company, the Advantages of Network Theory and the Rise of Populism in Contemporary United States
Authors: Heidingsfelder Markus , Khan Arqam 
Published: December 2017

This interview with network theorist Emily Erikson took place in March 2017 when she visited Habib University in Karachi, Pakistan, for a lecture on the English East India Company. She talks about the advantages of network theory, the challenges of Twitter research and the reasons for the success of the English East India Company, which—according to Erikson—cannot be successfully explained by using a European cultures versus South Asian cultures framework. It also touches upon the critique of corporations in general and the possible links between globalisation and the rise of populism in the United States. Emily Erikson teaches sociology at Yale University and works on social networks and the development of institutions of capitalism and democracy. Her award-winning book Between Monopoly and Free Trade: The English East India Company (Princeton University Press, 2014) shows how an informal social network linking autonomous employees fostered the company’s long-term success, shedding light on the processes underpinning the emergence of early multinational firms and the structure of early modern global trade. Her forthcoming book New Knowledge: The Rise of Economics and Development of the Public Sphere identifies the causes stimulating the development of pre-classical economic thought in the seventeenth century. Erikson serves on the council for economic sociology of the American Sociological Association and on the executive council of the Society for the Advancement of Socio-Economics. In addition, she serves on the editorial boards of Social Science History, Relational Sociology Series (Palgrave MacMillan), and is a founding member of the advisory board for the Journal of Historical Network Research.
Which factors influence the pursuit of a career in surgery? A national undergraduate survey
Authors: Rouhani Maral , Gelder Chloe , Selwyn-Gotha Jocelyn , Rufai Sohaib 
Published: December 2017

Background: Data from the UK's Core Surgery National Recruitment Office (CSNRO) indicates a downward trend in competition for surgical training posts. This national undergraduate survey aims to evaluate the factors influencing UK medical students' decisions to pursue surgical careers. Method: A web-based survey was distributed by email to UK medical schools via their medical school administration and undergraduate surgical societies. Results: Of the 137 students that responded, 100 (73.0%) stated that they were interested in a career in surgery – 62 students were considering this as their first choice specialty. The main reasons for choice of career were longstanding interest, exposure to the job environment and working environment. Reasons students were not considering a career in surgery included surgeons' attitudes, job competition and limited opportunities for learning in theatre. Anatomy teaching, basic surgical skills teaching and attendance at surgical society events increased the likelihood of pursuing a career in surgery. Conclusions: Greater career information, degree programme experience and medical school events were cited to help promote a career in surgery. It is imperative that surgeons are aware of how their attitude, and the experiences their students have during surgical placements, can influence students' career decisions.
COMENTARIOS BIBLIOGRÁFICOS: EL DELTA BONAERENSE: NATURALEZA, CONSERVACIÓN Y PATRIMONIO CULTURAL
Authors: López Hugo L. 
Published: December 2017

El Delta Bonaerense: naturaleza, conservación y patrimonio culturalAutor: Athor, J. (Ed.).Editorial: FundaciónHistoria Natural Félix de Azara.Año: 2014.Cantidad de páginas: 420.
Causal Evidence for Learning-Dependent Frontal Lobe Contributions to Cognitive Control
Authors: Muhle-Karbe Paul S. , Jiang Jiefeng , Egner Tobias 
Published: December 2017

The lateral prefrontal cortex (LPFC) plays a central role in the prioritization of sensory input based on task relevance. Such top-down control of perception is of fundamental importance in goal-directed behavior, but can also be costly when deployed excessively, necessitating a mechanism that regulates control engagement to align it with changing environmental demands. We have recently introduced the “flexible control model” (FCM), which explains this regulation as resulting from a self-adjusting reinforcement-learning mechanism that infers latent statistical structure in dynamic task environments to predict forthcoming states. From this perspective, LPFC-based control is engaged as a function of anticipated cognitive demand, a notion for which we previously obtained correlative neuroimaging evidence. Here, we put this hypothesis to a rigorous, causal test by combining the FCM with a transcranial magnetic stimulation (TMS) intervention that transiently perturbed the LPFC. Human participants (male and female) completed a nonstationary version of the Stroop task with dynamically changing probabilities of conflict between task-relevant and task-irrelevant stimulus features. TMS was given on each trial before stimulus onset either over the LPFC or over a control site. In the control condition, we observed adaptive performance fluctuations consistent with demand predictions that were inferred from recent and remote trial history and effectively captured by our model. Critically, TMS over the LPFC eliminated these fluctuations while leaving basic cognitive and motor functions intact. These results provide causal evidence for a learning-based account of cognitive control and delineate the nature of the signals that regulate top-down biases over stimulus processing.SIGNIFICANCE STATEMENTA core function of the human prefrontal cortex is to control the signal flow in sensory brain regions to prioritize processing of task-relevant information. Abundant work suggests that such control is flexibly recruited to accommodate dynamically changing environmental demands, yet the nature of the signals that serve to engage control remains unknown. Here, we combined computational modeling with noninvasive brain stimulation to show that changes in control engagement are captured by a self-adjusting reinforcement-learning mechanism that tracks changing environmental statistics to predict forthcoming processing demands and that transient perturbation of the prefrontal cortex abolishes these adjustments. These findings delineate the learning signals that underpin adaptive engagement of prefrontal control functions and provide causal evidence for their relevance in behavioral control.
Neuronal Glutamate Transporters Control Dopaminergic Signaling and Compulsive Behaviors
Authors: Bellini Stefania , Fleming Kelsey E. , De Modhurika , McCauley John P. , Petroccione Maurice A. , D'Brant Lianna Y. , Tkachenko Artem , Kwon SoYoung , Jones Lindsey A. , Scimemi Annalisa 
Published: December 2017

There is an ongoing debate on the contribution of the neuronal glutamate transporter EAAC1 to the onset of compulsive behaviors. Here, we used behavioral, electrophysiological, molecular, and viral approaches in male and female mice to identify the molecular and cellular mechanisms by which EAAC1 controls the execution of repeated motor behaviors. Our findings show that, in the striatum, a brain region implicated with movement execution, EAAC1 limits group I metabotropic glutamate receptor (mGluRI) activation, facilitates D1 dopamine receptor (D1R) expression, and ensures long-term synaptic plasticity. Blocking mGluRI in slices from mice lacking EAAC1 restores D1R expression and synaptic plasticity. Conversely, activation of intracellular signaling pathways coupled to mGluRI in D1R-containing striatal neurons of mice expressing EAAC1 leads to reduced D1R protein level and increased stereotyped movement execution. These findings identify new molecular mechanisms by which EAAC1 can shape glutamatergic and dopaminergic signals and control repeated movement execution.SIGNIFICANCE STATEMENTGenetic studies implicateSlc1a1, a gene encoding the neuronal glutamate transporter EAAC1, with obsessive-compulsive disorder (OCD). EAAC1 is abundantly expressed in the striatum, a brain region that is hyperactive in OCD. What remains unknown is how EAAC1 shapes synaptic function in the striatum. Our findings show that EAAC1 limits activation of metabotropic glutamate receptors (mGluRIs) in the striatum and, by doing so, promotes D1 dopamine receptor (D1R) expression. Targeted activation of signaling cascades coupled to mGluRIs in mice expressing EAAC1 reduces D1R expression and triggers repeated motor behaviors. These findings provide new information on the molecular basis of OCD and suggest new avenues for its treatment.