bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Nanosyntax of Spatial Deixis
Authors: Lander Eric , Haegeman Liliane 
Published: September 2016

AbstractThis paper provides a fine‐grained morphosyntactic analysis of spatial deixis. We propose that the universal core of spatial deixis is a three‐way contrast: Proximal ‘close to speaker’, Medial ‘close to hearer’, and Distal ‘far from speaker and hearer’. This system arises from three features merged as heads in a single universal functional sequence: Dx3 > Dx2 > Dx1. The hierarchy is understood in terms of superset‐subset relations, such that Proximal [Dx1] is a subset of Medial [Dx2 [Dx1]], which in turn is a subset of Distal [Dx3 [Dx2 [Dx1]]]. Evidence comes from patterns of syncretism and morphological containment in the demonstrative systems of a number of genetically diverse languages. Regarding syncretisms, languages can show a transparent three‐way morphological contrast, or some sort of syncretism: Medial/Proximal vs. Distal, Distal/Medial vs. Proximal, or a totally syncretic Distal/Medial/Proximal (i.e. a neutral demonstrative). These syncretisms entail that the features responsible for the Proximal and Medial readings be adjacent and that the features responsible for the Distal and Medial readings be adjacent in the fseq. Regarding containment, we show that Proximal can be structurally contained within Medial and that Medial can be structurally contained within Distal, meaning that Medial structures are larger than Proximal structures, and that Distal structures are larger than Medial structures, confirming our hierarchy. We show that these facts are naturally accounted for by nanosyntactic principles of spellout. We end the paper by accounting for potential counterexamples and other issues.
Why do within‐firm–product export prices differ across markets? Evidence from Hungary
Authors: Görg Holger , Halpern László , Muraközy Balázs 
Published: September 2016

AbstractIn this study, we analyse the relationship between distance and f.o.b. export unit values using firm–product–destination data from Hungarian manufacturing. Using 10‐digit Harmonized System data, we show that a doubling of distance is associated with about 7.5 per cent increase in the average product‐level price, from which five percentage points can be attributed to within‐firm–product variation. We run a number of tests to look for heterogeneity in this pattern. Interestingly, the measured effect is very similar for domestic and foreign firms but distance seems to matter somewhat more for EU countries than outside the EU. We do not find much evidence for heterogeneity across product categories based on measures of vertical differentiation. The level of product aggregation matters; the distance coefficient is larger when products are aggregate to the eight or six‐digit level.
Genome Sequences of 14
Firmicutes
Strains Isolated from the Human Vagina
Authors: Deitzler Grace E. , Ruiz Maria J. , Weimer Cory , Park SoEun , Robinson Lloyd , Hallsworth-Pepin Kymberlie , Wollam Aye , Mitreva Makedonka , Lewis Amanda L. , Lewis Warren G. 
Published: September 2016

ABSTRACT

Research on vaginal infections is currently limited by a lack of available fully sequenced bacterial reference strains. Here, we present strains (now available through BEI Resources) and genome sequences for a set of 14 vaginal isolates from the phylum
Firmicutes
. These genome sequences provide a valuable resource for future research in understanding the role of Gram-positive bacteria in vaginal health and disease.
A New Catalog of Microbiological Tools for Women's Infectious Disease Research
Authors: Lewis Amanda L. , Lewis Warren G. 
Published: September 2016

ABSTRACT
Genitourinary infections pose serious health risks. But, little is known about how genitourinary bacteria attach, maintain colonization, compete for resources, and cause pathology. In this issue, we introduce a new set of 62 genitourinary reference strains of bacteria and their genomes to spur experimental research on infectious diseases that impact women.
Complete Genome Sequence of Enterococcus faecalis Strain W11 Isolated from an Algal Food Product
Authors: Doi Yuki , Takizawa Noboru 
Published: September 2016

ABSTRACT

Here, we report the complete genome sequence of
Enterococcus faecalis
strain W11 isolated from an algal food product in Japan. This study should facilitate the identification of a novel mechanism of glycerol metabolic control in lactic acid bacteria.
First Complete Genome Sequence of
Bean common mosaic necrosis virus
from East Timor
Authors: Maina Solomon , Edwards Owain R. , de Almeida Luis , Ximenes Abel , Jones Roger A. C. 
Published: September 2016

ABSTRACT

We present here the first complete
Bean common mosaic necrosis virus
(BCMNV) genomic sequence isolated from virus-infected common bean (
Phaseolus vulgaris
) in East Timor, and compare it with six complete BMCNV genomes from the Netherlands, and one each from the United States, Tanzania, and an unspecified country. It most resembled the Netherlands strain NL-8 genome.
Central corneal thickness changes in bevel-up versus bevel-down phacoemulsification cataract surgery: study protocol for a randomised, triple-blind, parallel group trial
Authors: Kaup Soujanya , Shivalli Siddharudha , KS Divyalakshmi , Arunachalam Cynthia , Varghese Rejitha Chinnu 
Published: September 2016

IntroductionCorneal endothelial damage following phacoemulsification is still one of the major concerns of modern day cataract surgery. Although many techniques have been proposed, the risks of posterior capsular rupture and corneal endothelium damage persist. In theory, damage to the corneal endothelium is minimised by delivering the lowest phaco energy only in the direction necessary to emulsify the lens nucleus. Hence, it is believed that the bevel of the needle should be turned towards the nucleus or the nuclear fragment (ie, bevel-down. However, there is a difference of opinion among ophthalmologists with reference to the phaco tip's position (bevel-up vs bevel-down) during phacoemulsification. This subject has not been extensively studied earlier.Methods and analysisThis is a prospective, triple-blinded (trial participant, outcome assessor and the data analyst), randomised controlled trial with 2 parallel groups and with an allocation ratio of 1:1. It will be conducted in a tertiary care hospital, Mangaluru, India. The objective is to compare the postoperative central corneal thickness changes between the bevel-up and bevel-down techniques of phacoemulsification. Patients aged >18 years with immature cataract undergoing phacoemulsification will be selected for the study. The important exclusion criteria are the history of previous significant ocular trauma or intraocular surgery, corneal pathology, pseudoexfoliation syndrome, intraocular inflammation, a preoperative fully dilated pupil <6 mm, anterior chamber depth <2.5 mm and nuclear sclerosis grade >4. After randomisation, patients will undergo phacoemulsification surgery either by a bevel-up or bevel-down procedure. With an estimated power of 80%, the calculated sample size is 55 patients in each group. The recruitment will start from April 2016.Ethics and disseminationYenepoya University Ethics Committee, India has approved the study protocol (YUEC/148/2016 on 18 February 2016). It complies with the Declaration of Helsinki, local laws and the International Council for Harmonization-good clinical practices.Trial registration numberCTRI/2016/02/006691; Pre-results.
Fluorescent quantitative PCR detection ofMycobacterium tuberculosisin tissue sections from granulomatous lesions retrieved using EDTA
Authors: Wang Xuzhou , Xie Feilai , Zheng Qiaoling , Qi Xingfeng , Li Min , Zhou Xiaoling , Zheng Zhiyong 
Published: September 2016

AimsThis study aimed to use EDTA to retrieve paraffin-embedded tissue sections of inflammatory granulomatous lesions and increase the detection rate of tuberculosis (TB)/non-tuberculous mycobacteria. Due to the influence of chemical reagents during the fixation process, the amplification of fluorescent quantitative PCR was blocked after DNA extraction, and the results were not ideal.MethodsSpecial staining technologies (acid-fast and Auramine O) and fluorescent quantitative PCR were used to detect TB/non-tuberculous mycobacteria in 125 cases of inflammatory granulomatous lesions in paraffin-embedded tissue sections with and without EDTA retrieval.ResultsIn 125 cases of inflammatory granulomatous lesions, 75 cases (60%) were positive for mycobacteria using fluorescent quantitative PCR without EDTA retrieval, of which 74 cases (59.2%) were detected with TB mycobacteria and 1 case (0.8%) with non-tuberculous mycobacteria. The average cycle threshold value of positive specimens ranged from 29 to 32 (30.5). However, 88 cases (70.4%) were positive for mycobacteria using fluorescent quantitative PCR with EDTA retrieval, of which 83 cases (66.4%) were detected with TB mycobacteria and 5 cases (4%) with non-tuberculous mycobacteria. The average Ct value of positive specimens ranged from 27 to 30 (28.0). Statistical differences were found between the two groups (p<0.05; p<0.01).ConclusionsThis study showed that compared with special staining technologies (acid-fast and Auramine O) and molecular pathology detection, fluorescent quantitative PCR with EDTA retrieval could greatly improve the detection rate of TB/non-tuberculous mycobacteria and increase the sensitivity of the fluorescent quantitative PCR.
Diphoton channel at the LHC experiments to find a hint for a new heavy gauge boson
Authors: Kaneta Kunio , Kang Subeom , Lee Hye-Sung 
Published: September 2016

Recently there has been a huge interest in the diphoton excess around 750 GeV reported by both ATLAS and CMS collaborations, although the newest analysis with more statistics does not seem to support the excess. Nevertheless, the diphoton channel at the LHC experiments are a powerful tool to probe a new physics. One of the most natural explanations of a diphoton excess, if it occurs, could be a new scalar boson with exotic colored particles. In this setup, it would be legitimate to ask what is the role of this new scalar in nature. A heavy neutral gauge boson [Formula: see text] is one of the traditional targets of the discovery at the collider experiments with numerous motivations. While the Landau–Yang theorem dictates the diphoton excess cannot be this spin-1 gauge boson, there is a strong correlation of a new heavy gauge boson and a new scalar boson which provides a mass to the gauge boson being at the same mass scale. In this paper, we point out a simple fact that a new scalar with a property similar to the recently highlighted 750 GeV would suggest an existence of a TeV scale [Formula: see text] gauge boson that might be within the reach of the LHC Run 2 experiments. We take a scenario of the well-motivated and popular gauged [Formula: see text] symmetry and require the gauge coupling unification to predict the mass and other properties of the [Formula: see text] and illustrate the discovery of the [Formula: see text] would occur during the LHC experiments.
FOXO3a regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress
Authors: Chaanine Antoine H. , Kohlbrenner Erik , Gamb Scott I. , Guenzel Adam J. , Klaus Katherine , Fayyaz Ahmed U. , Nair K. Sreekumaran , Hajjar Roger J. , Redfield Margaret M. 
Published: September 2016

The forkhead box O3a (FOXO3a) transcription factor has been shown to regulate glucose metabolism, muscle atrophy, and cell death in postmitotic cells. Its role in regulation of mitochondrial and myocardial function is not well studied. Based on previous work, we hypothesized that FOXO3a, through BCL2/adenovirus E1B 19-kDa protein-interacting protein 3 (BNIP3), modulates mitochondrial morphology and function in heart failure (HF). We modulated the FOXO3a-BNIP3 pathway in normal and phenylephrine (PE)-stressed adult cardiomyocytes (ACM) in vitro and developed a cardiotropic adeno-associated virus serotype 9 encoding dominant-negative FOXO3a (AAV9.dn-FX3a) for gene delivery in a rat model of HF with preserved ejection fraction (HFpEF). We found that FOXO3a upregulates BNIP3 expression in normal and PE-stressed ACM, with subsequent increases in mitochondrial Ca2+, leading to decreased mitochondrial membrane potential, mitochondrial fragmentation, and apoptosis. Whereas dn-FX3a attenuated the increase in BNIP3 expression and its consequences in PE-stressed ACM, AAV9.dn-FX3a delivery in an experimental model of HFpEF decreased BNIP3 expression, reversed adverse left ventricular remodeling, and improved left ventricular systolic and, particularly, diastolic function, with improvements in mitochondrial structure and function. Moreover, AAV9.dn-FX3a restored phospholamban phosphorylation at S16 and enhanced dynamin-related protein 1 phosphorylation at S637. Furthermore, FOXO3a upregulates maladaptive genes involved in mitochondrial apoptosis, autophagy, and cardiac atrophy. We conclude that FOXO3a activation in cardiac stress is maladaptive, in that it modulates Ca2+ cycling, Ca2+ homeostasis, and mitochondrial dynamics and function. Our results suggest an important role of FOXO3a in HF, making it an attractive potential therapeutic target. Listen to this article's corresponding podcast at http://ajpheart.podbean.com/e/role-of-foxo3a-in-heart-failure/ .
Systemic GM-CSF Recruits Effector T Cells into the Tumor Microenvironment in Localized Prostate Cancer
Authors: Wei Xiao X. , Chan Stephen , Kwek Serena , Lewis Jera , Dao Vinh , Zhang Li , Cooperberg Matthew R. , Ryan Charles J. , Lin Amy M. , Friedlander Terence W. , Rini Brian , Kane Christopher , Simko Jeffry P. , Carroll Peter R. , Small Eric J. , Fong Lawrence 
Published: September 2016

Abstract
Granulocytic–macrophage colony-stimulating factor (GM-CSF) is used as an adjuvant in cancer vaccine trials and has the potential to enhance antitumor efficacy with immunotherapy; however, its immunologic effects are not fully understood. Here, we report results from a phase I study of neoadjuvant GM-CSF in patients with localized prostate cancer undergoing radical prostatectomy. Patients received subcutaneous injections of GM-CSF (250 μg/m2/day) daily for 2 weeks (cohort 1; n = 6), 3 weeks (cohort 2; n = 6), or 4 weeks (cohort 3; n = 6). Treatment was well tolerated with all grade 1 or 2 adverse events. Two patients had a decline in prostate-specific antigen (PSA) of more than 50%. GM-CSF treatment increased the numbers of circulating mature myeloid dendritic cells, proliferating conventional CD4 T cells, proliferating CD8 T cells, and to a lesser magnitude FoxP3+ regulatory CD4 T cells. Although GM-CSF treatment did not augment antigen-presenting cell localization to the prostate, treatment was associated with recruitment of CD8+ T cells to the tumor. These results suggest that systemic GM-CSF can modulate T-cell infiltration in the tumor microenvironment. Cancer Immunol Res; 4(11); 948–58. ©2016 AACR.
Comments on “Dynamics of Upper-Level Frontogenesis in Baroclinic Waves”
Authors: Buzzi Andrea 
Published: September 2016

Abstract
A recent paper by Mak et al. grants the opportunity to discuss two different definitions of the frontogenetical function proposed in the literature to study the formation and evolution of upper-level fronts. This comment exposes some problems that, in this author’s opinion, are related to the use of the Lagrangian tendency of the 3D (in place of horizontal) gradient of potential temperature, as adopted in the Mak et al. paper.
Identifying ELIXIR Core Data Resources
Authors: Durinx Christine , McEntyre Jo , Appel Ron , Apweiler Rolf , Barlow Mary , Blomberg Niklas , Cook Chuck , Gasteiger Elisabeth , Kim Jee-Hyub , Lopez Rodrigo , Redaschi Nicole , Stockinger Heinz , Teixeira Daniel , Valencia Alfonso 
Published: September 2016

The core mission of ELIXIR is to build a stable and sustainable infrastructure for biological information across Europe. At the heart of this are the data resources, tools and services that ELIXIR offers to the life-sciences community, providing stable and sustainable access to biological data. ELIXIR aims to ensure that these resources are available long-term and that the life-cycles of these resources are managed such that they support the scientific needs of the life-sciences, including biological research. ELIXIR Core Data Resources are defined as a set of European data resources that are of fundamental importance to the wider life-science community and the long-term preservation of biological data. They are complete collections of generic value to life-science, are considered an authority in their field with respect to one or more characteristics, and show high levels of scientific quality and service. Thus, ELIXIR Core Data Resources are of wide applicability and usage. This paper describes the structures, governance and processes that support the identification and evaluation of ELIXIR Core Data Resources. It identifies key indicators which reflect the essence of the definition of an ELIXIR Core Data Resource and support the promotion of excellence in resource development and operation. It describes the specific indicators in more detail and explains their application within ELIXIR’s sustainability strategy and science policy actions, and in capacity building, life-cycle management and technical actions. Establishing the portfolio of ELIXIR Core Data Resources and ELIXIR Services is a key priority for ELIXIR and publicly marks the transition towards a cohesive infrastructure.
A survival analysis of 1084 knees of the Oxford unicompartmental knee arthroplasty
Authors: Bottomley N. , Jones L. D. , Rout R. , Alvand A. , Rombach I. , Evans T. , Jackson W. F. M. , Beard D. J. , Price A. J. 
Published: September 2016

Aims The aim of this to study was to compare the previously unreported long-term survival outcome of the Oxford medial unicompartmental knee arthroplasty (UKA) performed by trainee surgeons and consultants. Patients and Methods We therefore identified a previously unreported cohort of 1084 knees in 947 patients who had a UKA inserted for anteromedial knee arthritis by consultants and surgeons in training, at a tertiary arthroplasty centre and performed survival analysis on the group with revision as the endpoint. Results The ten-year cumulative survival rate for revision or exchange of any part of the prosthetic components was 93.2% (95% confidence interval (CI) 86.1 to 100, number at risk 45). Consultant surgeons had a nine-year cumulative survival rate of 93.9% (95% CI 90.2 to 97.6, number at risk 16). Trainee surgeons had a cumulative nine-year survival rate of 93.0% (95% CI 90.3 to 95.7, number at risk 35). Although there was no differences in implant survival between consultants and trainees (p = 0.30), there was a difference in failure pattern whereby all re-operations performed for bearing dislocation (n = 7), occurred in the trainee group. This accounted for 0.6% of the entire cohort and 15% of the re-operations. Conclusion This is the largest single series of the Oxford UKA ever reported and demonstrates that good results can be achieved by a heterogeneous group of surgeons, including trainees, if performed within a high-volume centre with considerable experience with the procedure. Cite this article: Bone Joint J 2016;(10 Suppl B):22–7.
Searching for vernacular concepts in the contemporary scene: The Turkish floor table as a source of design inspiration
Authors: Nasir Esra Bici 
Published: September 2016

Abstract
Following reforms resulting from westernization, domestic culture in Turkey and related styles of using household items changed considerably. In the context of transformations regarding the withdrawal of vernacular items and practices, adapted, globally sourced forms of furniture became common in Turkish middle-class homes. This article focuses on the furniture and items related to eating, in which the modern dining table, connoting an established residence, is depicted as very different from the floor table which was representative of nomadic culture. Thus, the vernacular floor table and the contemporary dining table and other eating units are analysed in terms of their dichotomies – mobility/stability, lightness/heaviness, visibility/invisibility and emptiness/fullness – to ascertain ways to encourage the possibility of wider adoption of vernacular design qualities. Text and visual analyses were conducted on recent interior architecture and decoration magazines to seek out relationships to the vernacular design qualities to assess their adaptability to the contemporary environment. Research results illustrate that mobility, lightness, invisibility and emptiness are highly desired concepts but with novel diffractions and interpretations, still making the floor table a rich source of design inspiration.
France in Mali: Towards a new Africa strategy?
Authors: Chafer Tony 
Published: September 2016

Abstract
This article addresses the question whether the French military intervention in Mali in 2013 (Operation Serval) and the follow-up Operation Barkhane are evidence of a new French military strategy in Africa. The first part briefly sets out the chronology of events that led to the French intervention. The decisionmaking process in Paris that led to the decision to intervene and the sequence of events following the intervention is then examined, in order to show that this raised important questions about the viability of the key principles – partnership, ‘Africanization’ and ‘Europeanization’ – that informed and underpinned France’s Africa policy from the late 1990s. It is argued that Operation Serval and the follow-on operation, Barkhane, need to be understood, first, in the context of the importance attached to Africa as a privileged arena for the projection of French power overseas. Second, they must be understood in the geopolitical context of the neo-liberal post-Cold War international order, within which France, as a major western power and permanent member of the UNSC, feels it has a responsibility to undertake certain actions. Third, they should also be understood against the background of the failure to reform the institutional architecture of Africa policymaking, in particular the roles of the Ministry of Defence and the ‘Africa cell’ at the Elysée Palace, which have traditionally played a pivotal role in Africa policy. Finally, the article argues that a new Africa strategy did emerge under President Hollande, albeit in an unplanned and incremental manner, but that the resulting policy is some distance from representing a renovated, or ‘normalized’, Africa policy based on a new partnership with Africa.
Explicit Finite-Difference Scheme for the Numerical Solution of the Model Equation of Nonlinear Hereditary Oscillator with Variable-Order Fractional Derivatives
Authors: Parovik Roman I. 
Published: September 2016

Abstract
The paper deals with the model of variable-order nonlinear hereditary oscillator based on a numerical finite-difference scheme. Numerical experiments have been carried out to evaluate the stability and convergence of the difference scheme. It is argued that the approximation, stability and convergence are of the first order, while the scheme is stable and converges to the exact solution.