bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neuroticism and extraversion moderate neural responses and effective connectivity during appetitive conditioning
Authors: Schweckendiek Jan , Stark Rudolf , Klucken Tim 
Published: May 2016

AbstractClassical appetitive conditioning constitutes a basic learning process through which environmental stimuli can be associated with reward. Previous studies showed that individual differences in neuroticism and extraversion influence emotional processing and have been shown to modulate neural activity in subcortical and prefrontal areas in response to emotional stimuli. However, the role of individual differences in appetitive conditioning has so far not been investigated in detail. The aim of this study was to assess the association between neuroticism and extraversion with neural activity and connectivity during appetitive conditioning. The conditioned stimulus (CS) was either a picture of a dish or a cup. One stimulus (CS+) was paired with a monetary reward and the other stimulus (CS−) was associated with its absence while hemodynamic activity was measured by means of functional magnetic resonance imaging. A significant negative correlation of neuroticism scores with amygdala activity was observed during appetitive conditioning. Further, extraversion was positively associated with responses in the hippocampus and the thalamus. In addition, effective connectivity between the amygdala as a seed region and the anterior cingulate cortex, the insula, and the thalamus was negatively correlated with neuroticism scores and positively correlated with extraversion scores. The results may indicate a neural correlate for the deficits in appetitive learning in subjects with high neuroticism scores and point to a facilitating effect of extraversion on reward‐related learning. Hum Brain Mapp 37:2992–3002, 2016. © 2016 Wiley Periodicals, Inc.
Functional integration changes in regional brain glucose metabolism from childhood to adulthood
Authors: Trotta Nicola , Archambaud Frédérique , Goldman Serge , Baete Kristof , Van Laere Koen , Wens Vincent , Van Bogaert Patrick , Chiron Catherine , De Tiège Xavier 
Published: May 2016

AbstractThe aim of this study was to investigate the age‐related changes in resting‐state neurometabolic connectivity from childhood to adulthood (6–50 years old). Fifty‐four healthy adult subjects and twenty‐three pseudo‐healthy children underwent [18F]‐fluorodeoxyglucose positron emission tomography at rest. Using statistical parametric mapping (SPM8), age and age squared were first used as covariate of interest to identify linear and non‐linear age effects on the regional distribution of glucose metabolism throughout the brain. Then, by selecting voxels of interest (VOI) within the regions showing significant age‐related metabolic changes, a psychophysiological interaction (PPI) analysis was used to search for age‐induced changes in the contribution of VOIs to the metabolic activity in other brain areas. Significant linear or non‐linear age‐related changes in regional glucose metabolism were found in prefrontal cortices (DMPFC/ACC), cerebellar lobules, and thalamo‐hippocampal areas bilaterally. Decreases were found in the contribution of thalamic, hippocampal, and cerebellar regions to DMPFC/ACC metabolic activity as well as in the contribution of hippocampi to preSMA and right IFG metabolic activities. Increases were found in the contribution of the right hippocampus to insular cortex and of the cerebellar lobule IX to superior parietal cortex metabolic activities. This study evidences significant linear or non‐linear age‐related changes in regional glucose metabolism of mesial prefrontal, thalamic, mesiotemporal, and cerebellar areas, associated with significant modifications in neurometabolic connectivity involving fronto‐thalamic, fronto‐hippocampal, and fronto‐cerebellar networks. These changes in functional brain integration likely represent a metabolic correlate of age‐dependent effects on sensory, motor, and high‐level cognitive functional networks. Hum Brain Mapp 37:3017–3030, 2016. © 2016 Wiley Periodicals, Inc.
Kidney Injury Molecule Levels in Type 2 Diabetes Mellitus
Authors: Aslan Ozgur , Demir Metin , Koseoglu Mehmet 
Published: May 2016

BackgroundThis study was designed to determine the diagnostic role of urinary kidney injury molecule (KIM)‐1 levels in renal damage in patients with type 2 diabetes mellitus according to the urinary albumin/creatinine ratio.MethodsPatients with type 2 diabetes mellitus admitted to different polyclinics in our hospital enrolled in the study and were subdivided into three groups according to albumin/creatinine ratio – normalbuminuric (n: 20); microalbuminuric (n: 20); albuminuric (n: 18) – and compared with the control group. Urine albumin was analyzed using the immunoturbidimetric method (Architect C16000, Abbott Diagnostics). uKIM‐1 was determined using a commercially available enzyme‐linked immunosorbent assay test kit (USCN Life Science, Hankou, Wuhan, China). One‐sample Kolmogorov–Smirnov test, Spearman correlation and Kruskal–Wallis non‐parametric tests were performed. Post hoc comparisons were made using Bonferroni‐corrected Mann–Whitney U tests.ResultsThe differences between the controls and normalbuminuric, microalbuminuric and albuminuric groups were highly significant for KIM‐1. Positive correlation was found between KIM‐1 and urine microalbumin–urine microalbumin/creatinine (r = 0.479 P < 0.001; r = 0. 400, P < 0.001; respectively).ConclusionIn our study, KIM‐1 levels were significantly different suggesting that urinary KIM‐1 levels may be an early marker in patients with diabetic nephropathy. J. Clin. Lab. Anal. 00:1–6, 2016.
Genetic Characteristics of Polycythemia Vera and Essential Thrombocythemia in Korean Patients
Authors: Yoo Eun‐Hyung , Park Kyung‐Jin , Won Hong‐Hee , Park Jun‐Hee , Park Jong‐Ho , Lee Seung‐Tae , Kim Hee‐Jin , Bang Soo‐Mee , Chi Hyun‐Sook , Jung Chul Won , Kim Sun‐Hee , Yun Hongseok , Sun Choong‐Hyun , Park Inho , Lee Seungmook , Lee Clarence , Merriman Barry , Luo Raymond , Tan Eileen Hwee Hong , Park Keun‐Joon , Yoo Na‐Kyung , Kang Jason J. , Kim Jong‐Won 
Published: May 2016

BackgroundDespite recent advances in the investigation of myeloproliferative neoplasms (MPN), the impact of genetic heterogeneity on its molecular pathogenesis has not been fully elucidated. Thus, in this study, we aim to characterize the genetic complexity in Korean patients with polycythemia vera (PV) and essential thrombocythemia (ET).MethodsWe conducted association studies using 84 single‐nucleotide polymorphisms (SNPs) in 229 patients (96 with PV and 133 with ET) and 170 controls. Further, whole‐genome sequencing was performed in six patients (two with JAK2 V617F and four with wild‐type JAK2), and putative somatic mutations were validated in a further 69 ET patients. Clinical and laboratory characteristics were also analyzed.ResultsSeveral germline SNPs and the 46 haplotype were significantly associated with PV and ET. Three somatic mutations in MPDZ, IQCH, and CALR genes were selected and validated. The frequency of the CALR mutation was 58.0% (40/69) in ET patients, who did not carry JAK2/MPL mutations. Moreover, compared with JAK2 V617F‐positive patients, those with CALR mutations showed lower hemoglobin and hematocrit levels (P = 0.004 and P = 0.002, respectively), higher platelet counts (P =0.008), and a lower frequency of cytoreductive therapy (P = 0.014).ConclusionThis study was the first comprehensive investigation of the genetic characteristics of Korean patients with PV and ET. We found that somatic mutations and the 46 haplotype contribute to PV and ET pathogenesis in Korean patients.
Assessment and Monitoring of Soil Degradation during Land Use Change Using Multivariate Analysis
Authors: Khaledian Yones , Kiani Farshad , Ebrahimi Soheila , Brevik Eric C. , Aitkenhead‐Peterson Jacqueline 
Published: May 2016

AbstractNot only are soil erosion and overall loss of soil fertility serious issues for loess‐derived soils of developing nations, such as Iran, but they are also global problems. This research investigated the role of land use change and its effect on soil degradation in cultivated, pasture, and urban lands, when compared with native forest in terms of declining of soil quality and fertility. Multivariate statistical methods including principal component analysis and cluster analysis were employed to determine the relative magnitude of anthropogenic and natural influences on soil quality. Partial least squares (PLS), principal component regression, and ordinary least squares regression were used to predict soil cation exchange capacity using soil characteristics. Principal component analysis identified five primary components of soil quality. PC1 explained 41·01% of the total variance, PC2 accounted for 15·29%, and PC3 accounted for 11·3%. PC4 and PC5 accounted for 7·37% and 4·19% of the total variance, respectively. Cluster analysis revealed that the lowest soil quality occurred in urban soils. An exponential semivariogram using PLS predictions revealed stronger spatial dependence among cation exchange capacity [r2 = 0·80, root mean square error (RMSE) = 1·99] than the other methods, principal component regression [r2 = 0·84, RMSE = 2·45] and ordinary least squares [r2 = 0·84, RMSE = 2·45]. Therefore, the PLS method provided the best model for the data. In stepwise regression analysis, mean weight diameter and labile carbon were selected as influential variables in all soils. This study quantified reductions in numerous soil quality parameters resulting from extensive land‐use changes and urbanization in the Ziarat watershed in northern Iran. Copyright © 2016 John Wiley & Sons, Ltd.
Succinoglycan Octasaccharide Conjugated Polydiacetylene‐Doped Alginate Beads for Barium (II) Detection
Authors: Yun Deokgyu , Cho Eunae , Dindulkar Someshwar D. , Jung Seunho 
Published: May 2016

Detection methods for heavy metals are important and highly required due to their toxicity to the health of humans and the environment. Hence, using a polydiacetylene (PDA)‐based sensoring bead, the presence of barium ions is exclusively detected for the first time. The sensoring platform has been designed as a PDA vesicle functionalized with a succinoglycan octasaccharide subunit serving as a metal coordination ligand. First, the succinoglycan octasaccahride subunit is isolated from Sinorhizobium meliloti, successfully conjugated to pentacosa‐10,12‐diynoic acid via reductive amination, and the functionalized vesicle system is investigated for color and fluorescence changes targeting nine different metal ions. To further improve the long‐term storage stability and convenient handling of the vesicle detection system, the sensory vesicle is immobilized on millimeter‐sized alginate beads through the ionotropic gelation method. This study provides an opportunity to design and develop various carbohydrate‐based sensor materials.image
Nutritional depletion in n‐3 PUFA in apoE knock‐out mice: A new model of endothelial dysfunction associated with fatty liver disease
Authors: Catry Emilie , Neyrinck Audrey M. , Lobysheva Irina , Pachikian Barbara D. , Van Hul Matthias , Cani Patrice D. , Dessy Chantal , Delzenne Nathalie M. 
Published: May 2016

ScopeWestern diets are characterized by low intake of n‐3 PUFA compensated by constant amounts of n‐6 PUFA. Reduced intake of n‐3 PUFA is associated with increased cardiovascular risk, as observed in nonalcoholic fatty liver disease patients. The study aimed to evaluating the impact of dietary n‐3 PUFA depletion on endothelial function, an early key event of cardiovascular diseases.Methods and resultsC57Bl/6J or apolipoprotein E knock‐out (apoE−/−) were fed control (CT) or n‐3 PUFA‐depleted diets (DEF) for 12 wks. Mice fed n‐3 DEF diet developed a hepatic steatosis, linked to changes in hepatic expression of genes controlled by Sterol Regulatory Element Binding Protein‐1 and ‐2. Vascular function was assessed on second‐ and third‐order mesenteric arteries and n‐3 PUFA‐depleted apoE−/− mice presented endothelial dysfunction characterized by decreased vasorelaxation in response of acetylcholine. The presence of a nitric oxide synthase (NOS) inhibitor blunted the relaxation in each groups and heme‐nitrosylated hemoglobin blood (Hb‐NO) level was significantly lower in n‐3 PUFA‐depleted apoE−/− mice.ConclusionTwelve weeks of n‐3 DEF diet promote steatosis and accelerate the process of endothelial dysfunction in apoE−/− mice by a mechanism involving the NOS/NO pathway. We propose n‐3 PUFA‐depleted apoE−/− mice as a new model to study endothelial dysfunction related to hepatic steatosis independently of obesity.
Persistent metabolic adaptation 6 years after “The Biggest Loser” competition
Authors: Fothergill Erin , Guo Juen , Howard Lilian , Kerns Jennifer C. , Knuth Nicolas D. , Brychta Robert , Chen Kong Y. , Skarulis Monica C. , Walter Mary , Walter Peter J. , Hall Kevin D. 
Published: May 2016

ObjectiveTo measure long‐term changes in resting metabolic rate (RMR) and body composition in participants of “The Biggest Loser” competition.MethodsBody composition was measured by dual energy X‐ray absorptiometry, and RMR was determined by indirect calorimetry at baseline, at the end of the 30‐week competition and 6 years later. Metabolic adaptation was defined as the residual RMR after adjusting for changes in body composition and age.ResultsOf the 16 “Biggest Loser” competitors originally investigated, 14 participated in this follow‐up study. Weight loss at the end of the competition was (mean ± SD) 58.3 ± 24.9 kg (P < 0.0001), and RMR decreased by 610 ± 483 kcal/day (P = 0.0004). After 6 years, 41.0 ± 31.3 kg of the lost weight was regained (P = 0.0002), while RMR was 704 ± 427 kcal/day below baseline (P < 0.0001) and metabolic adaptation was −499 ± 207 kcal/day (P < 0.0001). Weight regain was not significantly correlated with metabolic adaptation at the competition's end (r = −0.1, P = 0.75), but those subjects maintaining greater weight loss at 6 years also experienced greater concurrent metabolic slowing (r = 0.59, P = 0.025).ConclusionsMetabolic adaptation persists over time and is likely a proportional, but incomplete, response to contemporaneous efforts to reduce body weight.
Distributed model predictive control with saturated inputs by a saturation‐dependent Lyapunov function
Authors: Zhang L. , Xie W. , Wang J. 
Published: May 2016

SummaryIn this paper, distributed model predictive control (MPC) problems are considered for input‐saturated polytopic uncertain systems by a saturation‐dependent Lyapunov function approach. The actuator saturation is processed by the transformation into the linear convex combination form. By the decomposition of the control input, distributed MPC controllers are designed in parallel for each subsystems. The Lyapunov Function we select is saturation dependent, which is less conservative than the general Lyapunov Function approach. An invariant set condition is provided and min–max distributed MPC is proposed based on the invariant set. The robust distributed MPC controllers are determined by solving a linear matrix inequality (LMI) optimization problem. To reduce the conservatism, we present a robust distributed MPC algorithm, which is not only saturation dependent but also parameter dependent. A Jacobi iterative algorithm is developed to coordinate the distributed MPC controllers. A simulation example with multi‐subsystem is carried out to demonstrate the effectiveness of the proposed distributed MPC algorithms. Copyright © 2016 John Wiley & Sons, Ltd.
Prenatal sonographic features of triploidy at 12–16 weeks
Authors: Zalel Yaron , Shapiro Israel , Weissmann‐Brenner Alina , Berkenstadt Michal , Leibovitz Zvi , Bronshtein Moshe 
Published: May 2016

AbstractObjectiveThe purpose of our study was to describe the sonographic appearance of triploidy in early pregnancy.MethodsWe report the sonographic characteristics of a cohort of fetal triploid cases detected at targeted ultrasonographic vaginal examinations between 12 and 16 weeks of gestation from 2008 to 2014. Indications for fetal karyotype following ultrasound were maternal request, advanced maternal age, increased nuchal translucency, and/or fetal abnormalities.ResultsTriploidy was detected in 25 cases during the 6 years of the study period with an estimated incidence of ~1 in 5000 pregnancies. Four cases had molar changes in the placenta. Among the remaining 21 cases, a consistent sonographic pattern was noted, which included the combination of asymmetric growth restriction with abdominal circumference lagging 2 weeks behind head circumference in 21/21, oligohydramnios in 20/21, abnormal posterior fossa or enlarged fourth ventricle in 20/21, and absent gall bladder in 17/21. Other findings present in more than 50% of cases included cardiac (70%) and renal (55%) abnormalities, clenched hands (55%), and hypoplastic lungs (67%).ConclusionFetal triploidy can manifest at 12–16 weeks with molar changes in the placenta or with a cluster of unusual sonographic findings whose presence should prompt appropriate testing for diagnosis in early pregnancy. © 2016 John Wiley & Sons, Ltd.
Haften wie ein Gecko
Authors: Greiner Christian , Hölscher Hendrik 
Published: May 2016

AbstractSeit der Antike gibt es verschiedene Theorien über die phänomenale Haftfähigkeit von Geckos. Heute ist klar, dass das Aufteilen der Kontaktfläche in sehr viele kleine Kontaktflächen ihre Haftkraft enorm steigert. Dafür sorgt eine hierarchisch aufgespaltene Härchenstruktur an den Zehen. Auf der molekularen Ebene dominieren Van‐der‐Waals‐Kräfte. Wichtig sind zudem die Fähigkeit zur Selbstreinigung und das Aufrollen der Zehen beim Ablösen. Diese drei Eigenschaften müssen künstliche Strukturen imitieren, wenn sie den Fähigkeiten der Geckos nahekommen sollen. Im Labor gelingen erste Ansätze, doch eine erfolgreiche Übertragung auf kommerzielle Gecko‐Klebebänder steht noch aus.
Skyrmionen – magnetische Wirbel als Datenspeicher
Authors: Büttner Felix , Kläui Mathias 
Published: May 2016

AbstractIn bestimmten Festkörpern lassen sich magnetische Wirbelstrukturen, sogenannte Skyrmionen, erzeugen. Gemeinsam mit Physikern des Massachusetts Institute of Technology ist es unserer Gruppe von der Universität Mainz kürzlich gelungen, gezielt einzelne Skyrmionen bei Raumtemperatur in einem Festkörper durch Strominjektion zu verschieben. Das ist ein wichtiger Schritt auf dem Weg, Skyrmionen als zukünftige Datenspeicher einzusetzen.
The digital filtration preprocessing of variable magnetic field Hall data before mobility spectrum analysis for p‐MCT films
Authors: Trifanov A. V. , Protasov D. Yu. , Kostyuchenko V. Ya. , Mikhailov N. N. , Dvoretsky S. A. 
Published: May 2016

AbstractThe variable‐field Hall data of p‐MCT films were filtered by weighting low‐pass digital filter with Blackman win‐dow before mobility spectrum analysis. The used cutoff frequencies lay in range 0.1‐0.7 Hz. It was obtained that the digital filtration allows determining of minor elec‐tron's mobility at low temperatures (77‐90 K). The electron mobility values, obtained by mobility spectrum analysis in conjunction with multicarrier fitting well agreed with result of photoconductivity in magnetic field for Faradays geometry.(© 2016 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
The v‐algorithm for discovering software process lines
Authors: Rojas Blum Fabian , Simmonds Jocelyn , Bastarrica María Cecilia 
Published: May 2016

AbstractA software company can define a software process line (SPrL) to deal with projects with different characteristics. This entails defining a base process and its variation points; the SPrL is then tailored to each project. This approach avoids the co‐evolution problems but is expensive to set up. In companies that register project events, this information could be used to discover the SPrL. However, traditional discovery algorithms focus on extracting a single process, which can be overly complex and would not be useful for managing future projects. Filtering out less frequent behavior leads to the discovery of simpler models, but these may not include relevant behavior. To address these issues, we propose the v‐algorithm, which discovers a SPrL from process logs. Two thresholds split the log into three clusters based on relation frequency. The first one is used to generate the base process, the second one is used to identify variable elements, and the last one is discarded. We used the v‐algorithm to discover the SPrL of Mobius, a small Chilean software company. We also discuss how the values of the thresholds affect the process discovery quality dimensions, extending existing metrics to the SPrL case. Copyright © 2016 John Wiley & Sons, Ltd.
Ein Bauwerk in Bewegung
Authors: Klähne Thomas , Gülay Hakan 
Published: May 2016

AbstractDer Berliner U‐Bahnhof Mendelssohn‐Bartholdy‐Park wird durch ein 14‐geschossiges Gebäude überbaut, wobei die Baugruben sehr dicht an die Bahnsteigbrücken des Bahnhofes heranreichen. Durch die Baumaßnahmen des Hochbaus entstehen Baugrundbewegungen, die die Gründungen des Bahnhofes und seiner Brücken beeinflussen. Zur Sicherung der Stand‐ und Verkehrssicherheit der östlichen Bahnsteigbrücke wurde eine justierbare Abfangkonstruktion entworfen. Im vorliegenden Beitrag wird über die Planung und Ausführung der Abfangkonstruktion sowie das Dauer‐Monitoring des Bahnhofes über die Bauzeit berichtet.A structure in motion – The Metro Station Mendelssohn Bartholdy Park. The Berlin Metro Station Mendelssohn‐Bartholdy‐Park is being overbuilt by a 14‐storey building of which the construction pits are situated very close to the existing platform bridges of the station. The construction measures lead to ground movements that have an effect on the foundations of the station and its bridges. In order to secure the structural integrity and the traffic safety of the eastern platform bridge an adjustable support structure has been designed. This article reports on the planning and execution of this structure as well as the permanent monitoring of the station over the whole construction period.
Die Dachkonstruktion des Aquamotion in Courchevel
Authors: Auger Gabriel , De Rycke Klaas , Bollinger Klaus , Grohmann Manfred , Weilandt Agnes 
Published: May 2016

AbstractDas Freizeit‐ und Wellnessbad “Aquamotion de Courchevel” ‐befindet sich im Herzen der Grandes Combes im Eingangsbereich des Ski‐Resorts auf einer Höhe von 1?500 m. Das Schwimmzentrum liegt als horizontale Plattform zwischen den Ausläufern der benachbarten Berge. Die Tragstruktur des Gebäudes besteht aus einem grundständigen Massivbau und einem Stahldach mit Abmessungen von 120 m × 80 m, das gleichsam aus dem Boden heraus wächst und den Massivbau mit einer minimalen Anzahl von 25 tragenden Stützen, zwei Wänden und drei Widerlagern überspannt.An einigen Stellen kragt das Dach bis zu 17 m aus. Seine Struktur wird durch vier große Dachöffnungen unterbrochen, die für die notwendige Belichtung im Innenraum sorgen und einen Blick über das Tal und über das großartige Alpenpanorama bieten.Courchevel's Aquamotion roof structure Saint‐Bon‐Courchevel, Frankreich. The Recreation and Wellness Spa “Aquamotion” in Saint‐Bon Courchevel is located in the heart of the Grandes Combes at the entrance of the ski resort at an elevation of 1?500 m. The Aquatic Centre is lies as a horizontal platform, wedged between the flanks of the neighbouring mountain scenery. The solid construction of the building has a steel roof area of 120 m × 80 m, rising up from the ground and providing a minimum of load‐bearing points: 25 columns, two walls and three abutments.At some points, the roof cantilevers up to 17 m. The necessary light enters through four different‐sized roof openings and offers a view over a remarkable Alpine panorama.h