bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and effectiveness of SOFIA/SOFIA PLUS for direct aspiration as first line treatment in patients with acute anterior ischemic stroke: results from the prospective, multicentric SESAME study
Authors: Neuberger Ulf , Marnat Gaultier , Barreau Xavier , Pitrone Antonio , Caragliano Antonio A. , Killer-Oberpfalzer Monika , Pfaff Johannes A. R. , Maurer Christoph J. , Berlis Ansgar , Bokkers Reinoud , Uyttenboogaart Maarten , Sourour Nader , Clarençon Frédéric , Wodarg Fritz , Cognard Christophe , Bohner Georg , Trenkler Johannes , Spelle Laurent , Weber Werner , Nouri Nasreddine , Bonekamp Susanne , Thomalla Götz , Fiehler Jens , Bendszus Martin , Möhlenbruch Markus A. 
Published: September 2024

BackgroundMechanical thrombectomy is a cornerstone treatment for acute ischemic stroke (AIS) with large vessel occlusion (LVO), yet the optimal technique remains debated. The SOFIA/SOFIA PLUS catheter has emerged as a promising tool for direct aspiration thrombectomy.PurposeThis prospective multi-center study, adhering Good-Clinical-Practice guidelines, aimed to evaluate the safety and efficacy of the SOFIA/SOFIA PLUS catheter for direct aspiration as a first-line treatment technique in patients with acute anterior circulation LVO.Materials and methodsBetween 10/2017 and 12/2021, 246 consecutive patients presenting with AIS due to anterior circulation LVO were enrolled from 14 European centers. Primary treatment with SOFIA catheters was performed within 6 h of symptom onset. Clinical and radiological data were collected, and statistical analyses were conducted.ResultsThe mean age of the included patients was 71.6 ± 13.9 years, with 44.7% being male. Primary aspiration achieved complete recanalization in 72.8% of patients, with functional independence observed in 63.8% after 90 days. Secondary outcomes included a median NIHSS of 4 at 24 h post-procedure, median ASPECTS of 7 on follow-up imaging, and a mortality rate of 24.4% at 90 days. No device malfunctions were observed, and the rate of symptomatic intracranial hemorrhage was 4.4%.ConclusionPrimary aspiration with the SOFIA/SOFIA PLUS catheter demonstrates favorable safety and efficacy profiles in the treatment of anterior circulation LVO. These findings support the utilization of this technique as a first-line approach in mechanical thrombectomy for AIS, contributing to the growing body of evidence endorsing the effectiveness of direct aspiration thrombectomy in stroke management.
METS-IR as an important predictor of neurological impairment severity in patients with severe cerebral infarction: a multicenter study based on the Chinese population
Authors: Hou Yaqi , Wu Xiaohua , Shi Yiheng , Xu Xiaotian , Zhang Yu , Jiang Lei , Wang Wei , Yang Yan , Hu Lanying 
Published: September 2024

BackgroundInsulin resistance (IR) is linked to an increased risk of neurological impairment following a stroke and may contribute to poor neurological prognosis in affected patients. The metabolic score for the insulin resistance index, shortened as the METS-IR, generally serves as a surrogate index for IR. However, its association with the severity of neurological impairment in patients with severe cerebral infarction (CI) in neurological intensive care units (ICU) has not been fully established.MethodsPatients with a diagnosis of CI, admitted to the neurological ICUs of Yangzhou University’s Affiliated Hospital and Xuzhou Medical University’s Affiliated Hospital, were included in the study. A multivariate logistic regression model and restricted cubic splines (RCS) were employed to explore the relationship between the METS-IR index and the severity of neurological impairment in these patients. The predictive capabilities of the METS-IR index and the triglyceride-glucose (TyG) index for outcome measures were compared through the ROC curve. Furthermore, a decision curve analysis was executed, and the integrated discrimination improvement (IDI) index was computed to evaluate the enhancements in predictive performance and clinical utility of various scoring systems with the inclusion of the METS-IR index. Subgroup analysis was conducted regarding age, BMI, and smoking status.ResultsThe study ultimately included 504 participants. Adjusted logistic regression and RCS results showed that as the METS-IR index increases, the risk of neurological impairment in patients with severe CI consistently grows (P for overall = 0.0146, P-nonlinear: 0.0689). The METS-IR index’s predictive capability for neurological impairment (AUC = 0.669) was superior to that of the TyG index (AUC = 0.519).ConclusionFrom the study results, the METS-IR index can serve as an important predictor for neurological impairment in ICU patients with severe CI. It can aid in the identification and early intervention of neurological impairment in these patients.
Genetic profile of progressive myoclonic epilepsy in Mali reveals novel findings
Authors: Cissé Lassana , Bamba Salia , Diallo Seybou H. , Ji Weizhen , Dembélé Mohamed Emile , Yalcouyé Abdoulaye , Coulibaly Toumany , Traoré Ibrahima , Jeffries Lauren , Diarra Salimata , Maiga Alassane Dit Baneye , Diallo Salimata , Nimaga Karamoko , Touré Amadou , Traoré Oumou , Kotioumbé Mahamadou , Mis Emily Kathryn , Cissé Cheick Abdel Kader , Guinto Cheick Oumar , Fischbeck Kenneth H. , Khokha Mustafa K. , Lakhani Saquib A. , Landouré Guida 
Published: September 2024

Background and objectivesProgressive myoclonic epilepsy (PME) is a group of neurological disorders characterized by recurrent myoclonic seizures with progressive neurological deterioration. We investigated the genetics of three unrelated patients with PME from Mali, a country in sub-Saharan Africa highly underrepresented in genetic and genomic research.MethodsParticipants were carefully examined and phenotyped. DNA was obtained for genetic analysis including whole exome sequencing (WES). In silico prediction tools and ACMG criteria were used to assess the deleteriousness of putative candidate variants.ResultsPedigree analysis suggests autosomal recessive inheritance patterns for one family and sporadic forms of PME for the two other cases. WES identified novel homozygous missense variants in all the three patients, one each for NHLRC1, EPM2A, and NEU1. The sequence variants segregated with PME in each family and in silico studies including protein 3D structures, CADD scores and ACMG criteria suggested that they were damaging.DiscussionPME is a group of clinically heterogeneous neurological disorders. Most reported cases in the literature are from European background with only a few cases described in North Africa. We report here novel pathogenic variants in three different genes causing PME phenotypes in three unrelated Malian patients, suggesting that genetic studies of underrepresented populations may expand the genetic epidemiology of PME. These findings also emphasize the need for inclusive genetic research to ensure a more targeted diagnostic and therapeutic approaches for diverse patient populations.
Bibliometric analysis of microRNAs and Parkinson’s disease from 2014 to 2023
Authors: Chen Lingshan , Chen Jianfei , Weng Wei , Wu Min , Zhou Xueping , Yan Pingkang 
Published: September 2024

BackgroundParkinson’s disease (PD) is a neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Recent research has emphasized a significant correlation between microRNAs (miRNAs) and PD. To identify key research areas, provide a comprehensive overview of current research in various fields, and propose potential directions for future studies, a bibliometric analysis was conducted on the involvement of miRNAs in Parkinson’s disease from 2014 to 2023.MethodsRelevant literature records were collected from the Web of Science Core Collection on February 29, 2024. Subsequently, the data underwent analysis using the Bibliometrix R package and VOSviewer (version 1.6.19).ResultsThe annual scientific publications on miRNAs and Parkinson’s disease demonstrated an increasing trend, with an annual growth rate of 12.67%. China, the United States, and India emerged as the top three most productive countries/regions. The University of Barcelona had the highest annual publications, followed by Central South University and the Helmholtz Association. The INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES held the top position in terms of H-index and total citations, reflecting its extensive influence and prolific publication output. Kim, J., Junn, E., Hébert, S.S., and Doxakis, E. were the most frequently co-cited authors in the field. Based on the analysis of keywords, the most frequently occurring terms included “alpha-synuclein,” “neurodegenerative disease,” “exosome,” “neuroinflammation,” “oxidative stress,” “autophagy,” and “amyotrophic lateral sclerosis,” which have emerged as prominent research topics. Concurrently, there has been notable interest in topics such as “ceRNA,” “lncRNAs,” “mitochondrial dysfunction,” and “circular RNA.”ConclusionThis study focused on identifying emerging trends and critical research topics in the bibliometric analysis of microRNAs related to Parkinson’s disease. These findings highlight the diverse research landscape and evolving trend of miRNA-related research in PD. The field of miRNA research in Parkinson’s disease is actively exploring the underlying mechanisms of miRNA function, identifying potential diagnostic markers, and developing innovative therapeutic strategies. The results of our study offer significant contributions to researchers’ ability to track contemporary developments and guide the trajectory of future research in this domain.
Expanding the scope: multimodal dimensions in aphasia discourse analysis—preliminary findings
Authors: Dutta Manaswita , Mohapatra Bijoyaa 
Published: September 2024

BackgroundAphasia, resulting from acquired brain injury, disrupts language processing and usage, significantly impacting individuals’ social communication and life participation. Given the limitations of traditional assessments in capturing the nuanced challenges faced by individuals with aphasia, this study seeks to explore the potential benefits of integrating multimodal communication elements into discourse analysis to better capture narrative proficiency in this population.ObjectiveThis study examined how incorporating multimodal communication elements (e.g., physical gestures, writing, drawing) into discourse analysis may affect the narrative outcomes of persons with aphasia compared to those observed using methods that exclude multimodal considerations.MethodsParticipants included individuals with chronic aphasia and age-and education-matched healthy controls who completed a storytelling task—the Bear and the Fly story. Macrolinguistic scores were obtained using verbal-only and multimodal scoring approaches. Additionally, the frequency and type of multimodal communication use during storytelling were examined in relation to aphasia characteristics. Statistical analyses included both within-group and between-group comparisons as well as correlational analyses.ResultsIndividuals with aphasia scored significantly higher in terms of their macrolinguistic abilities when multimodal scoring was considered compared to verbal-only scoring. Within the aphasia group, there were prominent differences noted in macrolinguistic scores for both fluent and nonfluent aphasia. Specifically, both groups scored higher on Main Concepts when multimodal scoring was considered, with the nonfluent group demonstrating significantly higher Main Concept and total macrolinguistic rubric scores in multimodal scoring compared to verbal scoring on the storytelling task. Additionally, aphasia severity showed moderate positive correlations with total macrolinguistic scores, indicating that individuals with less severe aphasia tended to produce higher quality narratives. Lastly, although persons with aphasia used different types of nonverbal modalities (i.e., drawing, writing), the use of meaning-laden gestures was most predominant during storytelling, emphasizing the importance of multimodal elements in communication for individuals with aphasia.ConclusionOur preliminary study findings underscore the importance of considering multimodal communication in assessing discourse performance among individuals with aphasia. Tailoring assessment approaches based on aphasia subtypes can provide valuable insights into linguistic abilities and inform targeted intervention strategies for improving communication outcomes.
Finger-specific effects of age on tapping speed and motor fatigability
Authors: Heimhofer Caroline , Neumann Amira , Odermatt Ingrid , Bächinger Marc , Wenderoth Nicole 
Published: September 2024

IntroductionIncreased motor fatigability is a symptom of many neuromuscular and neurodegenerative disorders. However, it is difficult to pinpoint pathological motor fatigability, since the phenomena has not yet been fully characterized in the healthy population. In this study, we investigate how motor fatigability differs across age. Given that many disorders involve supraspinal components, we characterize motor fatigability with a paradigm that has previously been associated with supraspinal mechanisms. Finger tapping at maximal speed results in a rapid decrease in movement speed, which is a measure of motor fatigability.MethodsWe collected finger tapping data in a field experiment from the general population with a smartphone app, and we investigated age differences in maximal tapping speed, as well as the decrease in tapping speed for the index, middle, and little fingers.ResultsWe found that the maximal tapping speed differed significantly between young (18–30 years, n = 194) and aged (50–70 years, n = 176), whereas the fatigability-induced relative decrease in movement speed did not differ between the age groups (average decrease: 17.0% ± 6.9% (young) vs. 16.5% ± 7.5% (aged) decrease). Furthermore, tapping speed and motor fatigability depended on which finger was used.DiscussionThese findings might relate to dexterity, with more dexterous movements being more resistant to fatigue. In this study, we provide a characterization of motor fatigability in the general population which can be used as a comparison for clinical populations in the future.
Dietary inflammatory index and all-cause mortality in adults with COPD: a prospective cohort study from the NHANES 1999–2018
Authors: Tian Tu-Lei , Zhi Tian-Yu , Xie Mei-Ling , Jiang Ya-Lin , Qu Xiang-Kun 
Published: September 2024

BackgroundChronic inflammation is closely linked to Chronic Obstructive Pulmonary Disease (COPD); however, the impact of the Dietaryq Inflammatory Index (DII) on mortality among COPD patients remains uncertain.ObjectiveTo assess the correlation between the DII and all-cause mortality in COPD patients using data from the National Health and Nutrition Examination Survey (NHANES).MethodsWe conducted a retrospective cohort study on 1,820 COPD patients from the NHANES dataset (1999-2018). The influence of DII on mortality was evaluated using multivariate Cox regression, smoothing spline fitting, and threshold effect analysis. Additionally, Kaplan-Meier survival analysis was performed to compare survival curves among different DII groups. Subgroup analyses and E-values identified sensitive cohorts and assessed unmeasured confounding.ResultsOver an average follow-up of 91 months, multivariate Cox regression models revealed a significant positive correlation between DII scores and mortality risk, with each unit increase in DII associated with a 10% higher risk of death (HR: 1.10, 95% CI: 1.03-1.16; P = 0.002). Among the DII tertiles, individuals in the second tertile (T2: 1.23-2.94) experienced a 67% increase in mortality risk compared to those in the lowest tertile (T1: -5.28-1.23) (HR: 1.67, 95% CI: 1.26-2.21; p &lt; 0.001). The third tertile (T3) did not show a statistically significant increase in mortality risk (HR: 1.30, 95% CI: 0.98-1.72; p=0.074). A restricted cubic spline analysis indicated a significant nonlinear association between DII and all-cause mortality (p = 0.021). Threshold effect analysis further revealed that below a DII of 2.19, there was a significant increase in all-cause mortality risk (HR = 1.19, 95% CI: 1.07-1.33; p = 0.002), while at or above this threshold, the risk increase was not statistically significant (HR=0.89, 95% CI: 0.68-1.15; p = 0.380). Kaplan-Meier analysis revealed significant differences in survival curves among DII tertiles (p &lt; 0.001), with the lowest DII tertile showing the highest survival probability. Both subgroup and sensitivity analyses confirmed the robustness of these findings.ConclusionDII is positively correlated with mortality risk in COPD patients, showing nonlinear characteristics and threshold effects, underscoring its prognostic value.
Association between serum iron levels and atherosclerotic cardiovascular diseases among American older adults: a cross-sectional study based on the National Health and Nutrition Examination Survey, 2009–2018
Authors: Yu Xiaochen , Li Min , Chen Bingxing , Qi Yuan , Guan Xiuru 
Published: September 2024

BackgroundThere is controversy regarding the relationship between serum iron levels and atherosclerotic cardiovascular disease (ASCVD).ObjectiveTo investigate the relationship between serum iron levels and ASCVD among older adults using data from the 2009–2018 National Health and Nutrition Examination Survey (NHANES).MethodsWe performed a cross-sectional analysis involving 8,682 participants aged 60 years and older, with complete data on serum iron levels and confirmed ASCVD status, sourced from the 2009–2018 National Health and Nutrition Examination Survey (NHANES). Multivariable logistic regression models were used to examine the association between serum iron levels and ASCVD. To assess the consistency of this association across different demographic groups, subgroup analyses, and interaction tests were performed.ResultsThe group with the highest serum iron levels (fourth quartile, 100–369 μg/dL) exhibited several distinct characteristics: they were the youngest on average (69.57 ± 6.91 years), had the highest proportion of males (61.42%), and the highest hemoglobin levels (14.43 ± 1.33 g/dL). This group also showed the lowest iron supplement usage (19.71 ± 12.85 mg/30 days), white blood cell counts (6.73 ± 2.41 1,000 cells/μL), and serum creatinine levels (0.98 ± 0.45 mg/dL). Moreover, they had higher levels of education and income, a higher likelihood of being married, and a lower body mass index (BMI). Additionally, they had significantly lower rates of diabetes, hypertension, stroke, and heart attacks (all p &lt; 0.05). After adjusting for potential confounders, a linear relationship between serum iron levels and ASCVD was initially observed (OR = 0.97; 95% CI, 0.95–0.99, p &lt; 0.05). However, further analysis using a two-part logistic regression model with an inflection point at 131 μg/dL revealed more nuanced results. For serum iron levels below 131 μg/dL, each 10 μg/dL increase was associated with a 4% decrease in the odds of ASCVD (OR = 0.96; 95% CI, 0.93–0.98, p &lt; 0.001). Conversely, for serum iron levels above 131 μg/dL, each 10 μg/dL increase corresponded to a 1% increase in the odds of ASCVD, though this finding was not statistically significant (OR = 1.01; 95% CI, 0.98–1.08, p &gt; 0.05).ConclusionIn the US elderly population, serum iron levels are negatively associated with ASCVD, particularly when serum iron levels are below 131 μg/dL.
Association between dopamine genes, adiposity, food addiction, and eating behavior in Chilean adult
Authors: Luengo Nicole , Goldfield Gary S. , Obregón Ana M. 
Published: September 2024

BackgroundA frequent consumption of high sugar/fat foods can affect dopamine signaling in the brain and cause sustained stimulation of the reward system. It has been hypothesized that a hypodopaminergic trait results in an individual overeating in order to increase brain DA. Genetic variants in this route have been connected with addiction and eating behaviors. Most studies focus on a specific SNP, and few studies have used multilocus genetic scores, which quantify genetic risk on a continuum.AimTo assess the relationship between multilocus genetic scores based on multiple gene variants in the dopaminergic pathway and measurements of anthropometry, eating behavior, food reinforcement, and food addiction (FA) in Chilean adults.MethodsWe recruited 221 Chilean adults for a cross-sectional study. A standard anthropometric measurement procedure was followed and eating behavior was examined using the Three Factor Eating questionnaire (TFEQ), Food Reinforcement Value Questionnaire (FRVQ), Yale Food Addiction Scale (YFAS) and 24-h diet recall. Multilocus genetic scores were calculated using TaqMan assays (rs1800497-rs1799732-rs6277-rs4680).ResultsNo differences were found in the entire sample for anthropometric measurements, by MLGS. We found that participants with a score ≥ 2.0 in the MLGS showed higher food choices on the RVFQ and lower energy intake in protein, lipids, SAFA, MUFA, PUFA, dietary cholesterol, omega-3 and Omega-6 fatty acids in the 24-h recall (p &lt; 0.05). Stratified by nutritional condition, the group with obesity had inferior scores on cognitive restriction, greater scores on uncontrolled eating, emotional eating, and responding to palatable food in the RVFQ. Also, in subjects with obesity, there was more food addiction in the group scoring “MLGS ≥2.0 or low dopamine signaling” (53%), compared to the group scored “MLGS &lt;2.0 or high dopamine signaling” (23%) (p-value; 0.05). Emotional Eating scores correlated positively with MLGS in subjects with obesity.ConclusionIn adults with obesity, the MLGS of the dopamine pathway, reflecting hypodopaminergic signaling, was associated with greater scores on food addiction and altered eating behavior traits.
Global burden and health inequality of nutritional deficiencies from 1990 to 2019
Authors: Yu Yang , Li Hui , Hu Nan-xi , Wu Xiao-hua , Huang Xin-yi , Lin Hong-tao , Yu Kai-li , Li Jin-luan 
Published: September 2024

IntroductionNutritional deficiencies (NDs) manifest in various forms and are widespread globally. However, a systematic evaluation of the epidemiology of NDs across all causes and age groups in different countries and regions has not been conducted.Materials and methodsThis study aimed to utilize data from the 2019 Global Burden of Disease (GBD) study to assess the burden and trends of NDs, including their incidence, prevalence, mortality, and disability-adjusted life years (DALYs). Additionally, the study evaluated health inequalities at global, regional, and national levels from 1990 to 2019.ResultIn 2019, the age-standardized incidence rate of NDs was 2,207.71 per 100,000 individuals (95% UI 1,863.04–2,604.67), and the age-standardized DALYs (ASR-DALYs) was 680.12 per 100,000 individuals (95% UI 507.21–894.89). Among the causes of NDs, dietary iron deficiency had the highest ASR-DALYs and exhibited minimal variation. Children under the age of 5 years faced the greatest risk of NDs. Sex disparity was evident, with males having lower rates than females. Although the gap in the burden of NDs between regions classified as poor and wealthy decreased, disparities persist.ConclusionThese findings provide critical insights for the development of global health strategies aimed at mitigating NDs and may guide policymakers in implementing effective and economically viable interventions.