bluuebunny/crossref_metadata_2025_split huggingface dataset:
Different effects of chronic THC on the neuroadaptive response of dopamine D2/3 receptor‐mediated signaling in roman high‐ and roman low‐avoidance rats
Authors: Tournier Benjamin B. , Dimiziani Andrea , Tsartsalis Stergios , Millet Philippe , Ginovart Nathalie 
Published: December 2017

AbstractThe Roman high (RHA)‐ and low (RLA)‐avoidance rat sublines have been identified as an addiction‐prone and addiction‐resistant phenotype based on their high vs. low locomotor responsiveness to novelty and high vs. low ability to develop neurochemical and behavioral sensitization to psychostimulants, respectively. Most studies though have focused on psychostimulants and little is known about the neuroadaptive response of these two lines to cannabinoids. This study investigated the effects of chronic exposure to Δ9‐tetrahydrocannabinol (THC) on dopamine D2/3 receptor (D2/3R) availabilities and functional sensitivity in the mesostriatal system of RHA and RLA rats. At baseline, RLA rats exhibited higher densities of mesostriatal D2/3R but lower levels of striatal CB1R mRNA and displayed a lower locomotor response to acute THC as compared to RHAs. Following chronic THC treatment, striking changes in D2/3R signaling were observed in RLA but not in RHA rats, namely an increased availability and functional supersensitivity of striatal D2/3R, as evidenced by a supersensitive psychomotor response to the D2/3R agonist quinpirole. Moreover, in RLA rats, the lower was the locomotor response to acute THC, the higher was the psychomotor response to quinpirole following chronic THC. These results showing a greater neuroadaptive response of RLA vs. RHA rats to chronic THC thus contrast with previous studies showing a resistance to neuroadaptive response of RLAs to psychostimulants, This suggests that, contrasting with their low proneness to psychostimulant drug‐seeking, RLAs may exhibit a heightened proneness to cannabinoid drug‐seeking as compared to RHA rats.
Lithium‐Associated Hypercalcemia: Pathophysiology, Prevalence, Management
Authors: Meehan Adrian D. , Udumyan Ruzan , Kardell Mathias , Landén Mikael , Järhult Johannes , Wallin Göran 
Published: December 2017

AbstractBackgroundLithium‐associated hypercalcemia (LAH) is an ill‐defined endocrinopathy. The aim of the present study was to determine the prevalence of hypercalcemia in a cohort of bipolar patients (BP) with and without concomitant lithium treatment and to study surgical outcomes for lithium‐associated hyperparathyroidism.MethodsRetrospective data, including laboratory results, surgical outcomes and medications, were collected from 313 BP treated with lithium from two psychiatric outpatient units in central Sweden. In addition, data were collected from 148 BP without lithium and a randomly selected control population of 102 individuals. Logistic regression was used to compare odds of hypercalcemia in these respective populations.ResultsThe prevalence of lithium‐associated hypercalcemia was 26%. Mild hypercalcemia was detected in 87 out of 563 study participants. The odds of hypercalcemia were significantly higher in BP with lithium treatment compared with BP unexposed to lithium (adjusted OR 13.45; 95% CI 3.09, 58.55; p = 0.001). No significant difference was detected between BP without lithium and control population (adjusted OR 2.40; 95% CI 0.38, 15.41; p = 0.355). Seven BP with lithium underwent surgery where an average of two parathyroid glands was removed. Parathyroid hyperplasia was present in four patients (57%) at the initial operation. One patient had persistent disease after the initial operation, and six patients had recurrent disease at follow‐up time which was on average 10 years.ConclusionThe high prevalence of LAH justifies the regular monitoring of calcium homeostasis, particularly in high‐risk groups. If surgery is necessary, bilateral neck exploration should be considered in patients on chronic lithium treatment. Prospective studies are needed.
Quantitative Assessment and Interpretation of Vaginal Conditions
Authors: Egorov Vladimir , Murphy Miles , Lucente Vincent , van Raalte Heather , Ephrain Sonya , Bhatia Nina , Sarvazyan Noune 
Published: December 2017

Abstract

Introduction
Few means exist to provide quantitative and reproducible assessment of vaginal conditions from biomechanical and functional standpoints.

Aim
To develop a new approach for quantitative biomechanical characterization of the vagina.

Methods
Vaginal tactile imaging (VTI) allows biomechanical assessment of soft tissue and function along the entire length of the anterior, posterior, and lateral vaginal walls. This can be done at rest, with applied vaginal deformation, and with pelvic muscle contraction.

Results
Data were analyzed for 42 subjects with normal pelvic floor support from an observational case-controlled clinical study. The average age was 52 years (range = 26–90 years). We introduced 8 VTI parameters to characterize vaginal conditions: (i) maximum resistance force to insertion (newtons), (ii) insertion work (millijoules), (iii) maximum stress-to-strain ratio (elasticity; kilopascals per millimeter), (iv) maximum pressure at rest (kilopascals), (v) anterior-posterior force at rest (newtons), (vi) left-right force at rest (newtons), (vii) maximum pressure at muscle contraction (kilopascals), and (viii) muscle contraction force (newtons). We observed low to moderate correlation of these parameters with subject age and no correlation with subject weight. 6 of 8 parameters demonstrated a P value less than .05 for 2 subject subsamples divided by age (≤52 vs &gt;52 years), which means 6 VTI parameters change with age.

Conclusions
VTI allows biomechanical and functional characterization of the vaginal conditions that can be used for (i) understanding “normal” vaginal conditions, (ii) quantification of the deviation from normality, (iii) personalized treatment (radiofrequency, laser, or plastic surgery), and (iv) assessment of the applied treatment outcome.
Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease
Authors: Leuzy Antoine , Rodriguez‐Vieitez Elena , Saint‐Aubert Laure , Chiotis Konstantinos , Almkvist Ove , Savitcheva Irina , Jonasson My , Lubberink Mark , Wall Anders , Antoni Gunnar , Nordberg Agneta 
Published: December 2017

AbstractIntroductionCross‐sectional findings using the tau tracer [18F]THK5317 (THK5317) have shown that [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early‐frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single PET study can provide both functional and molecular information.MethodsWe included 16 patients with Alzheimer's disease who completed follow‐up THK5317 and FDG studies 17 months after baseline investigations. Linear mixed‐effects models and annual percentage change maps were used to examine longitudinal change.ResultsLimited spatial overlap was observed between areas showing declines in THK5317 perfusion measures and FDG. Minimal overlap was seen between areas showing functional change and those showing increased retention of THK5317.DiscussionOur findings suggest a spatiotemporal offset between functional changes and tau pathology and a partial uncoupling between perfusion and metabolism, possibly as a function of Alzheimer's disease severity.
The cross-national structure of mental disorders: results from the World Mental Health Surveys
Authors: de Jonge Peter , Wardenaar Klaas J. , Lim Carmen C.W. , Aguilar-Gaxiola Sergio , Alonso Jordi , Andrade Laura Helena , Bunting Brendan , Chatterji Somnath , Ciutan Marius , Gureje Oye , Karam Elie G. , Lee Sing , Medina-Mora Maria Elena , Moskalewicz Jacek , Navarro-Mateu Fernando , Pennell Beth-Ellen , Piazza Marina , Posada-Villa José , Torres Yolanda , Kessler Ronald C. , Scott Kate 
Published: December 2017

AbstractBackgroundThe patterns of comorbidity among mental disorders have led researchers to model the underlying structure of psychopathology. While studies have suggested a structure including internalizing and externalizing disorders, less is known with regard to the cross-national stability of this model. Moreover, little data are available on the placement of eating disorders, bipolar disorder and psychotic experiences (PEs) in this structure.MethodsWe evaluated the structure of mental disorders with data from the World Health Organization Composite International Diagnostic Interview, including 15 lifetime mental disorders and six PEs. Respondents (n= 5478–15 499) were included from 10 high-, middle- and lower middle-income countries across the world aged 18 years or older. Confirmatory factor analyses (CFAs) were used to evaluate and compare the fit of different factor structures to the lifetime disorder data. Measurement invariance was evaluated with multigroup CFA (MG-CFA).ResultsA second-order model with internalizing and externalizing factors and fear and distress subfactors best described the structure of common mental disorders. MG-CFA showed that this model was stable across countries. Of the uncommon disorders, bipolar disorder and eating disorder were best grouped with the internalizing factor, and PEs with a separate factor.ConclusionsThese results indicate that cross-national patterns of lifetime common mental-disorder comorbidity can be explained with a second-order underlying structure that is stable across countries and can be extended to also cover less common mental disorders.
SAY NO SCORE: A LEXICAL IMPROVISATION AFTER BOB OSTERTAG
Authors: Williams Christopher 
Published: December 2017

AbstractMusic that features the interface of notation and improvisation tends to dwell in liminal regions of musical labour. It thus calls much entrenched musical vocabulary into question. The word score is one such example. What seems like a synonym for notation in everyday parlance turns out to be something quite different on closer inspection – more regulatory, yet at the same time more inclusive. This article explores three different meanings of the word score through the lens of composer-improviser Bob Ostertag's 1990s tetralogySay No More: a cut, an index of a game, and a record kept.Say No Moreconsists of a chain of tape pieces and ensemble pieces in which performers Joey Baron, Mark Dresser, Gerry Hemingway and Phil Minton were put in front of a machine-made mirror of themselves … with wacky lenses that distorted the image into something superhuman. In the performances the musicians tried to keep up with their digital reflection, a task at which they could only fail. Although the notation seems to play a minor role in this dynamic, its usage in the score as a whole offers important lessons on what writing might still have to offer composers in the digital era.
NARRATIVES OF ORIGINALITY IN COMPETITIVE COMPOSITION OPPORTUNITIES FOR ‘EMERGING COMPOSERS’
Authors: Smith Neil Thomas , Thwaites Rachel 
Published: December 2017

ABSTRACTThis article investigates the tension between originality and success for ‘emerging composers’ involved in composition opportunities in the British contemporary classical music scene. It utilises survey responses from 47 new music composers to better understand their experiences of these very public signs of compositional success. Though the narrative of the original artist is still significant, conflicts arise between ‘uniqueness’ and the realities of the composition opportunity. Composers aspire to be original, but are aware that a number of other, more instrumental, factors play a crucial role in being chosen. Despite the continuing importance of opportunities to many composers’ development, there are areas that could be made more transparent to ensure they are benefitting an aesthetically diverse range of artists.
‘IT'S NOT SOMETHING ONE CAN DELIBERATELY SET OUT TO DO’: CHRISTIAN WOLFF IN CONVERSATION
Authors: Gardner James , Fox Christopher 
Published: December 2017

ABSTRACTIn 2002 Christian Wolff was a guest composer at the Huddersfield Contemporary Music Festival and during the course of the festival he was interviewed by Christopher Fox and by James Gardner. Fox's interview took place before an audience in the Lawrence Batley Theatre on 25 November; Gardner's interview was recorded in private in the George Hotel, Huddersfield on 27 November, and edited excerpts from that recording were subsequently used in a programme produced by Radio New Zealand. The conversation presented here has been compiled by James Gardner from his transcriptions of the two interviews and presents a wide-ranging discussion of Wolff's musical preoccupations across every phase of his compositional career, from the early piano pieces of the 1950s, to his involvement with indeterminacy in the 1960s, to the political concerns evident in his music after 1970, to the works of the last three decades in which indeterminate and determinate methods of composition are combined.
TOWARD INTEGRATION IN THE CONTEXT OF HEALTH TECHNOLOGY ASSESSMENT: THE NEED FOR EVALUATIVE FRAMEWORKS
Authors: van der Wilt Gert Jan , Gerhardus Ansgar , Oortwijn Wija 
Published: December 2017

Objectives: A comprehensive health technology assessment (HTA) enables a patient-centered assessment of the effectiveness, economic, ethical, socio-cultural, and legal issues of health technologies that takes context and implementation into account. A question is whether these various pieces of evidence need to be integrated, and if so, how that might be achieved. The objective of our study is to discuss the meaning of integration in the context of HTA and suggest how it may be achieved in a more structured way.Methods: An analysis of the concept of integration in the context of HTA and a review of approaches that were adopted in the INTEGRATE-HTA project that may support integration.Results: Current approaches to integration in HTA are mainly methods of commensuration, which are not optimally geared to support public deliberation. In contrast, articulating evaluative frameworks could be an important means of integration which allows for exploring how facts and values can be brought to bear on each other.Conclusions: Integration is not something that only needs to be addressed at the end, but rather throughout an HTA, right from the start. Integration can be conceived as a matter of accounting for the relevance of empirical evidence in view of a commitment to a set of potentially conflicting values. Various elements of the INTEGRATE-HTA project, such as scoping and the development of logic models, can help to achieve integration in HTA.
The Kennedy–Johnson Tax Cut of 1964, the Defeat of Keynes, and Comprehensive Tax Reform in the United States
Authors: Mozumi Seiichiro 
Published: December 2017

Abstract:In 1964, President Lyndon B. Johnson, the successor of John F. Kennedy, signed into law the largest tax cut in U.S. history until 1981, the so-called Kennedy–Johnson tax cut. Many scholars have evaluated it as representative Keynesian tax policy; this article focuses on the effort of the Treasury Department, tax experts such as Stanley S. Surrey and Wilbur D. Mills, the chairman of House Committee on Ways and Means, to reform the federal income tax system comprehensively—making it simpler, fairer, and more equitable—and their defeat by the 1964 tax cut. Through the policymaking and legislative process, the Kennedy administration’s Council Economic Advisers defeated the Treasury and Surrey by domesticating Keynes’s ideas on tax policy. Until the 1964 passage of the tax cut, Mills, with his inconsistent action, abandoned the accomplishment of their ideal tax reform.
Integrated Water Resources Management and Collaboration: The Failure of the Klamath River Agreements
Authors: McCool Daniel 
Published: December 2017

Abstract:Integrated Water Resources Management (IWRM) is one of the most utilized models in water policy and administration. One of the crucial components in IWRM is collaboration, where multiple stakeholders negotiate solutions. This article explores the role of collaboration in one of the most contentious water conflicts in the nation—the Klamath River. The range of stakeholders is enormous and complex, including Indian tribes, farmers, fishermen, recreationists, environmentalists, advocates of endangered species, two states, and multiple federal agencies. The parties in the Klamath Basin negotiated three settlements to resolve many of the major issues. However, the U.S. Congress failed to approve the settlements in late 2015, effectively ending this long-term effort to resolve these vexing issues through collaborative negotiations. This conflict is analyzed using a multimethod approach, and discusses how the failure of the settlement process can provide insights into the role of collaboration in IWRM, and suggests refinements to the model.
Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex
Authors: Naik Roshan R. , Sotnikov Sergey V. , Diepold Rebekka P. , Iurato Stella , Markt Patrick O. , Bultmann Andrea , Brehm Nadine , Mattheus Tobias , Lutz Beat , Erhardt Angelika , Binder Elisabeth B. , Schmidt Ulrike , Holsboer Florian , Landgraf Rainer , Czibere Ludwig 
Published: December 2017

AbstractTMEM132D is a candidate gene, where risk genotypes have been associated with anxiety severity along with higher mRNA expression in the frontal cortex of panic disorder patients. Concurrently, in a high (HAB) and low (LAB) trait anxiety mouse model, Tmem132d was found to show increased expression in the anterior cingulate cortex (aCC) of HAB as compared to LAB mice. To understand the molecular underpinnings underlying the differential expression, we sequenced the gene and found two single-nucleotide polymorphisms (SNPs) in the promoter differing between both lines which could explain the observed mRNA expression profiles using gene reporter assays. In addition, there was no difference in basal DNA methylation in the CpG Island that encompasses the HAB vs. LAB Tmem132d promoter region. Furthermore, we found significantly higher binding of RNA polymerase II (POLR2A) to the proximal HAB-specific SNP (rs233264624) than the corresponding LAB locus in an oligonucleotide pull-down assay, suggesting increased transcription. Virus mediated overexpression of Tmem132d in the aCC of C57BL/6 J mice could confirm its role in mediating an anxiogenic phenotype. To model gene–environmental interactions, HAB mice exposed to enriched environment (HAB-EE) responded with decreased anxiety levels but, had enhanced Tmem132d mRNA expression as compared to standard-housed HAB (HAB-SH) mice. While LAB mice subjected to unpredictable chronic mild stress (LAB-UCMS) exhibited higher anxiety levels and had lower mRNA expression compared to standard-housed LAB (LAB-SH) mice. Chromatin immunoprecipitation revealed significantly higher binding of POLR2A to rs233264624 in HAB-EE, while LAB-UCMS had lower POLR2A binding at this locus, thus explaining the enhanced or attenuated expression of Tmem132d compared to their respective SH controls. To further investigate gene–environment interactions, DNA methylation was assessed using Illumina 450 K BeadChip in 74 panic disorder patients. Significant methylation differences were observed in two CpGs (cg26322591 and cg03283235) located in TMEM132D depending on the number of positive life events supporting the results of an influence of positive environmental cues on regulation of Tmem132d expression in mice.
Assembly of an early-matured japonica (Geng) rice genome, Suijing18, based on PacBio and Illumina sequencing
Authors: Nie Shou-Jun , Liu Yu-Qiang , Wang Chun-Chao , Gao Shi-Wei , Xu Tian-Tian , Liu Qing , Chang Hui-Lin , Chen Yu-Bao , Yan Peng-Cheng , Peng Wei , Zheng Tian-Qing , Xu Jian-Long , Li Zhi-Kang 
Published: December 2017

AbstractThe early-matured japonica (Geng) rice variety, Suijing18 (SJ18), carries multiple elite traits including durable blast resistance, good grain quality, and high yield. Using PacBio SMRT technology, we produced over 25 Gb of long-read sequencing raw data from SJ18 with a coverage of 62×. Using Illumina paired-end whole-genome shotgun sequencing technology, we generated 59 Gb of short-read sequencing data from SJ18 (23.6 Gb from a 200 bp library with a coverage of 59× and 35.4 Gb from an 800 bp library with a coverage of 88×). With these data, we assembled a single SJ18 genome and then generated a set of annotation data. These data sets can be used to test new programs for variation deep mining, and will provide new insights into the genome structure, function, and evolution of SJ18, and will provide essential support for biological research in general.
Emergence of Stimuli-Controlled Switchable Bifunctional Catalysts
Authors: Choudhury Joyanta , Semwal Shrivats 
Published: December 2017

Can a single catalyst perform more than one ‘type’ of reaction? If we consider traditional design of catalysts, then the answer would probably be ‘no’. However, with the advancement of catalyst design concepts, chemists have been able to demonstrate the above task, thanks to ‘stimuli-switchable bifunctional catalysts’. Within the nascent research area of ‘artificial switchable catalysis’, this new type of system offers the potential to achieve complex functions which are otherwise difficult or impossible. This Synpacts article highlights the rise of these new-generation catalysts.1	Introduction2	Key Advances3	Conclusion
The Evolution of Damage Control in Concept and Practice
Authors: Beldowicz Brian 
Published: December 2017

AbstractDamage control surgery (DCS) began as an adjunct approach to hemorrhage control, seeking to facilitate the body's innate clotting ability when direct repair or ligation was impossible, but it has since become a valuable instrument for a broader collection of critically ill surgical patients in whom metabolic dysfunction is the more immediate threat to life than imminent exsanguination. Modern damage control is a strategy that combines the principles of DCS with those of damage control resuscitation. When used correctly, damage control may improve survival in previously unsalvageable patients; when used incorrectly, it can subject patients to imprudent risk and contribute to morbidity. This review discusses the evolution of damage control in both concept and practice, summarizing available literature and experience to guide patient selection, medical decision-making, and strategy implementation throughout the preoperative, intraoperative, and early postoperative periods.
Colonoscopic Perforations
Authors: Mishra Nitin , Rai Vinay 
Published: December 2017

AbstractColonoscopy is the gold standard for colon cancer screening. It has led to a decrease in the incidence of colorectal cancer mortality. Colon perforation is a feared complication of this procedure with high morbidity and substantial mortality. Due to the high volume of colonoscopies performed, the absolute number of colonoscopic perforations is relatively high. It leads to a substantial cost to the patient and the health system. Understanding the mechanisms and the risk factors may help in preventing perforation. Traditionally, a laparotomy with creation of a stoma was used to address this complication. However, minimally invasive techniques such as laparoscopy and endoluminal repairs are being used more commonly now. More surgeons are favoring primary anastomosis (with or without a diverting loop ileostomy) than a Hartmann procedure.