bluuebunny/crossref_metadata_2025_split huggingface dataset:
3D dynamics and control of a snake robot in uncertain underwater environment
Authors: Patel Bhavik M. , Dwivedy Santosha K. 
Published: September 2024

Abstract
The snake robot can be used to monitor and maintain underwater structures and environments. The motion of a snake robot is achieved by lateral undulation which is called the gait pattern of the snake robot. The parameters of a gait pattern need to be adjusted for compensating environmental uncertainties. In this work, 3D motion dynamics of a snake robot for the underwater environment is proposed with vertical motion using the buoyancy variation technique and horizontal motion using lateral undulation. “The neutral buoyant snake robot motion in hypothetical plane and added mass effect is negligible”, these previous assumptions are removed in this work. Two different control algorithms are designed for horizontal and vertical motions. The existing super twisting sliding mode control (STSMC) is used for the horizontal serpentine motion of the snake robot. The control law is designed on a reduced-ordered dynamic system based on virtual holonomic constraints. The vertical motion is achieved by controlling the mass variation using a pump. The water pumps are controlled using the event-based controller or Proportional Derivative (PD) controller. The results of the proposed control technique are verified with various external environmental disturbances and uncertainties to check the robustness of the control approach for various path following cases. Moreover, the results of STSMC scheme are compared with SMC scheme to check the effectiveness of STSMC. The practical implementation of the work is also performed using Simscape Multibody environment where the designed control algorithm is deployed on the virtual snake robot.
The Five-Year Plan and target allocation cycle of environmental pollution in China
Authors: Ren Liuqing , Wang Renhe 
Published: September 2024

SummaryThis paper establishes a theoretical connection between China’s Five-Year Plan (FYP) and environmental pollution. We propose a target allocation cycle theory to explain the periodic feature of environmental pollution, which advances political business theory in different institutional contexts. By analysing industrial SO2 and PM2.5 data as well as the political career data of officials in 277 Chinese cities from 2003 to 2019, we reveal a significant influence of China’s political business cycles, as dictated by the FYP, on the periodicity of environmental pollution. Specifically, the emissions of industrial SO2 and PM2.5 exhibit a U-shaped periodic trend, peaking during the initial 2 years of each FYP, followed by a gradual decline in subsequent years, only to peak again in the first year of the succeeding FYP. These findings suggest that local political leaders strategically allocate their efforts in managing environmental pollution. Initially, there is a relaxation of environmental regulation during the early stages of a FYP, which is then followed by a shift towards more stringent environmental governance after the midpoint of the FYP.
A unified model of lenition as modulation reduction: gauging consonant strength in Ibibio
Authors: Harris John , Urua Eno-Abasi , Tang Kevin 
Published: September 2024

AbstractWe review and elaborate an account of consonantal strength that is founded on the model of speech as a modulated carrier signal. The stronger the consonant, the greater the modulation. Unlike approaches based on sonority or articulatory aperture, the account offers a uniform definition of the phonetic effect lenition has on consonants: All types of lenition (such as debuccalisation, spirantisation and vocalisation) reduce the extent to which a consonant modulates the carrier. To demonstrate the quantifiability of this account, we present an analysis of Ibibio, in which we investigate the effects of lenition on the amplitude, periodicity and temporal properties of consonants. We propose a method for integrating these different acoustic dimensions within an overall measure of modulation size. Not only does the modulated-carrier account cover all the classically recognised lenition types, but it also encompasses loss of plosive release in final stops – which, although not traditionally classed as lenition, is clearly related to processes that are.
Korean vowel harmony has weak phonotactic support and has limited productivity
Authors: Jo Jinyoung 
Published: September 2024

AbstractChong (2017) claims that a derived environment process is productive to the extent that it is supported by phonotactics. The present study tests this claim by comparing variable patterns observed in Korean vowel harmony of suffix alternation with vowel co-occurrence restrictions in the lexicon. A corpus study replicated findings of previous studies that the harmony in suffix alternation is losing productivity, conditioned by the quality of the stem vowel, the number of intervening consonants between the vowels and the stem class. Phonotactic generalisations in vowel sequences matched such tendencies in the alternation in that harmony was feeble in phonotactics and that some of the factors that modulate the harmony in alternation were found to affect the harmony in phonotactics as well. The findings generally support Chong’s claim that lack of phonotactic support for an alternation makes it harder to learn.
T0-spaces and the lower topology
Authors: Lawson Jimmie , Xu Xiaoquan 
Published: September 2024

AbstractThe authors’ primary goal in this paper is to enhance the study of
$T_0$
topological spaces by using the order of specialization of a
$T_0$
-space to introduce the lower topology (with a subbasis of closed sets
$\mathord{\uparrow } x$
) and studying the interaction of the original topology and the lower topology. Using the lower topology, one can define and study new properties of the original space that provide deeper insight into its structure. One focus of study is the property R, which asserts that if the intersection of a family of finitely generated sets
$\mathord{\uparrow } F$
,
$F$
finite, is contained in an open set
$U$
, then the same is true for finitely many of the family. We first show that property R is equivalent to several other interesting properties, for example, the property that all closed subsets of the original space are compact in the lower topology. We then find conditions under which these spaces are compact, well-filtered, and coherent, a weaker variant of stably compact spaces. We also investigate what have been called strong
$d$
-spaces, develop some of their basic properties, and make connections with the earlier considerations involving spaces satisfying property R. Two key results we obtain are that if a dcpo
$P$
with the Scott topology is a strong
$d$
-space, then it is well-filtered, and if additionally the Scott topology of the product
$P\times P$
is the product of the Scott topologies of the factors, then the Scott space of
$P$
is sober. We also exhibit connections of this work with de Groot duality.
Effects of different temperatures on the embryonic development of the Lebranche mullet Mugil liza
Authors: Manhães João Vitor de Azevedo , Mattos Douglas da Cruz , Strassburguer Rômulo Alves , Palma Ulysses da Silva , Sterzelecki Fabio Carneiro , Owatari Marco Shizuo , Magnotti Caio , Cerqueira Vinicius Ronzani 
Published: September 2024

SummaryWe herein investigated the influence of temperature on the embryonic development (from fertilisation to hatching) of Mugil liza larvae. For this purpose, oocytes (>600 μm) and sperm were obtained from breeding stock at the laboratory of marine fish culture (LAPMAR). After fertilisation, 1200 eggs were distributed in 12 cylindrical experimental units of 400 mL under four different temperatures 18, 22, 26 and 30 ºC, all in triplicate. Every 15 min until hatching, about 10 eggs were randomly sampled in each treatment. The eggs were visualized and photographed, and the classification of embryonic stages was performed. Temperature influenced the main events of the embryonic development of M. liza. More accelerated development was observed according to the increase in temperature until the gastrula phase. At temperatures of 22 and 26 °C, embryonic development occurred from fertilisation to hatching of the larvae. In the 18 °C treatment, it was verified that most of the embryos ceased development during the final phase of cleavage and the beginning of blastula formation, while in the 30 °C treatment patterns of embryo malformation were also verified, with erratic divisions of the blastomeres, resulting in irregular cells. Unlike what was observed at a temperature of 18 °C, none of the embryos incubated at 30 °C reached the blastopore closure phase, stopping in the gastrula. The larvae hatched in the treatments at 22 and 26 °C were viable and exhibited intense swimming, with a large amount of reserve material (yolk) and an evident drop of oil.
Chinese primers along the north-western frontier
Authors: Galambos Imre 
Published: September 2024

AbstractBy the second half of the first millennium CE, a substantial body of texts written in Literary Sinitic developed into a shared repertoire of writings throughout Central and East Asia. In no small part, this was the result of the spread of Buddhism, which, in many regions, was adopted in its Sinitic form and relied on Chinese versions of the scriptures. As part of the means to cope with Sinitic Buddhist texts, most states also adopted a range of auxiliary texts, including primers and dictionaries. While modern scholarship has directed substantial attention at the participation of Japan, Korea, and Vietnam in the world of Sinitic texts, it has placed much less emphasis on the western and north-western regions of what is now China. This article attempts to redress the imbalance and demonstrate not only that, at one point, Inner Asian states actively participated in the Sinographic world, but also that they did this through a similar process of adaptation to that documented elsewhere. Primers played a special role in this, in that they had a more immediate connection with the core competency of reading and writing.
EMBED IN ENSEMBLE TO RIGOROUSLY AND ACCURATELY HOMOGENIZE QUASI-PERIODIC MULTI-SCALE HETEROGENEOUS MATERIAL
Authors: ROBERTS ANTHONY 
Published: September 2024

AbstractFor microscale heterogeneous partial differential equations (PDEs), this article further develops novel theory and methodology for their macroscale mathematical/asymptotic homogenization. This article specifically encompasses the case of quasi-periodic heterogeneity with finite scale separation: no scale separation limit is required. A key innovation herein is to analyse the ensemble of all phase-shifts of the heterogeneity. Dynamical systems theory then frames the homogenization as a slow manifold of the ensemble. Depending upon any perceived scale separation within the quasi-periodic heterogeneity, the homogenization may be done in either one step or two sequential steps: the results are equivalent. The theory not only assures us of the existence and emergence of an exact homogenization at finite scale separation, it also provides a practical systematic method to construct the homogenization to any specified order. For a class of heterogeneities, we show that the macroscale homogenization is potentially valid down to lengths which are just twice that of the microscale heterogeneity! This methodology complements existing well-established results by providing a new rigorous and flexible approach to homogenization that potentially also provides correct macroscale initial and boundary conditions, treatment of forcing and control, and analysis of uncertainty.
Masculinity and (Hetero)Sexuality in the Late Imperial Russian Military
Authors: Hearne Siobhán 
Published: September 2024

AbstractThis article examines how sexual health became an important component of ideal military masculinity in the final decades of the Russian Empire. Rising rates of venereal diseases (VD) in the military in the final years of the nineteenth century forced the Russian imperial state to increasingly turn their attention to the sexual health and hygienic habits of military personnel. State officials enlisted the help of military physicians, who prepared sex education brochures and lectures with the aim of reducing venereal infection. Sex education materials encouraged conscripts to abandon the habits and practices of rural life and embrace “modern” hygienic manhood. Physicians saw military personnel as an important link to the Empire’s vast lower-class population and regarded the inculcation of new norms of health and hygiene within military populations as a key method for improving public health more generally, especially in the countryside. Within this context, expert knowledge became intertwined with visions of ideal military masculinity, and good sexual health and hygiene were presented as important markers of manhood.
Scenario Storyline Discovery for Planning in Multi‐Actor Human‐Natural Systems Confronting Change
Authors: Hadjimichael Antonia , Reed Patrick M. , Quinn Julianne D. , Vernon Chris R. , Thurber Travis 
Published: September 2024

AbstractScenarios have emerged as valuable tools in managing complex human‐natural systems, but the traditional approach of limiting focus on a small number of predetermined scenarios can inadvertently miss consequential dynamics, extremes, and diverse stakeholder impacts. Exploratory modeling approaches have been developed to address these issues by exploring a wide range of possible futures and identifying those that yield consequential vulnerabilities. However, vulnerabilities are typically identified based on aggregate robustness measures that do not take full advantage of the richness of the underlying dynamics in the large ensembles of model simulations and can make it hard to identify key dynamics and/or storylines that can guide planning or further analyses. This study introduces the FRamework for Narrative Storylines and Impact Classification (FRNSIC; pronounced “forensic”): a scenario discovery framework that addresses these challenges by organizing and investigating consequential scenarios using hierarchical classification of diverse outcomes across actors, sectors, and scales, while also aiding in the selection of scenario storylines, based on system dynamics that drive consequential outcomes. We present an application of this framework to the Upper Colorado River Basin, focusing on decadal droughts and their water scarcity implications for the basin's diverse users and its obligations to downstream states through Lake Powell. We show how FRNSIC can explore alternative sets of impact metrics and drought dynamics and use them to identify drought scenario storylines, that can be used to inform future adaptation planning.
Refined Estimates of Global Ocean Deep and Abyssal Decadal Warming Trends
Authors: Johnson Gregory C. , Purkey Sarah G. 
Published: September 2024

AbstractDeep and abyssal layer decadal temperature trends from the mid‐1980s to the mid‐2010s are mapped globally using Deep Argo and historical ship‐based Conductivity‐Temperature‐Depth (CTD) instrument data. Abyssal warming trends are widespread, with the strongest warming observed around Antarctic Bottom Water (AABW) formation regions. The warming strength follows deep western boundary currents transporting abyssal waters north and decreases with distance from Antarctica. Abyssal cooling trends are found in the North Atlantic and eastern South Atlantic, regions primarily ventilated by North Atlantic Deep Water (NADW). Deep warming trends are prominent in the Southern Ocean south of about 50°S, the Greenland‐Iceland‐Norwegian (GIN) Seas and the western subpolar North Atlantic, with cooling in the eastern subpolar North Atlantic and the subtropical and tropical western North Atlantic. Globally integrated decadal heat content trends of 21.6 (±6.5) TW in the deep and 12.9 (±1.8) TW in the abyssal layer are more certain than previous estimates.
Crosstalk between FTH1 and PYCR1 dysregulates proline metabolism and mediates cell growth in KRAS-mutant pancreatic cancer cells
Authors: Park Ji Min , Su Yen-Hao , Fan Chi-Shuan , Chen Hsin-Hua , Qiu Yuan-Kai , Chen Li-Li , Chen Hsin-An , Ramasamy Thamil Selvee , Chang Jung-Su , Huang Shih-Yi , Chang Wun-Shaing Wayne , Lee Alan Yueh-Luen , Huang Tze-Sing , Kuo Cheng-Chin , Chiu Ching-Feng 
Published: September 2024

AbstractFerritin, comprising heavy (FTH1) and light (FTL) chains, is the main iron storage protein, and pancreatic cancer patients exhibit elevated serum ferritin levels. Specifically, higher ferritin levels are correlated with poorer pancreatic ductal adenocarcinoma (PDAC) prognosis; however, the underlying mechanism and metabolic programming of ferritin involved in KRAS-mutant PDAC progression remain unclear. Here, we observed a direct correlation between FTH1 expression and cell viability and clonogenicity in KRAS-mutant PDAC cell lines as well as with in vivo tumor growth through the control of proline metabolism. Our investigation highlights the intricate relationship between FTH1 and pyrroline-5-carboxylate reductase 1 (PYCR1), a crucial mitochondrial enzyme facilitating the glutamate-to-proline conversion, underscoring its impact on proline metabolic imbalance in KRAS-mutant PDAC. This regulation is further reversed by miR-5000-3p, whose dysregulation results in the disruption of proline metabolism, thereby accentuating the progression of KRAS-mutant PDAC. Additionally, our study demonstrated that deferasirox, an oral iron chelator, significantly diminishes cell viability and tumor growth in KRAS-mutant PDAC by targeting FTH1-mediated pathways and altering the PYCR1/PRODH expression ratio. These findings underscore the novel role of FTH1 in proline metabolism and its potential as a target for PDAC therapy development.
Characterization of ACTN4 as a novel antiviral target against SARS-CoV-2
Authors: Zhu Miao , Huang Fang , Sun Huize , Liu Kunpeng , Chen Zhen , Yu Baocheng , Hao Haojie , Liu Haizhou , Ding Shuang , Zhang Xueyan , Liu Lishi , Zhang Kui , Ren Jierao , Liu Yi , Liu Haibin , Shan Chao , Guan Wuxiang 
Published: September 2024

AbstractThe various mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose a substantial challenge in mitigating the viral infectivity. The identification of novel host factors influencing SARS-CoV-2 replication holds potential for discovering new targets for broad-spectrum antiviral drugs that can combat future viral mutations. In this study, potential host factors regulated by SARS-CoV-2 infection were screened through different high-throughput sequencing techniques and further identified in cells. Subsequent analysis and experiments showed that the reduction of m6A modification level on ACTN4 (Alpha-actinin-4) mRNA leads to a decrease in mRNA stability and translation efficiency, ultimately inhibiting ACTN4 expression. In addition, ACTN4 was demonstrated to target nsp12 for binding and characterized as a competitor for SARS-CoV-2 RNA and the RNA-dependent RNA polymerase complex, thereby impeding viral replication. Furthermore, two ACTN4 agonists, YS-49 and demethyl-coclaurine, were found to dose-dependently inhibit SARS-CoV-2 infection in both Huh7 cells and K18-hACE2 transgenic mice. Collectively, this study unveils the pivotal role of ACTN4 in SARS-CoV-2 infection, offering novel insights into the intricate interplay between the virus and host cells, and reveals two potential candidates for future anti-SARS-CoV-2 drug development.
Box-Behnken design (BBD) for optimization and simulation of biolubricant production from biomass using aspen plus with techno-economic analysis
Authors: Abdel Hamid Eman M. , Amer Amer M. , Mahmoud Ahmed K. , Mokbl Eslam M. , Hassan Mazen A. , Abdel-Monaim Mohamed O. , Amin Rana H. , Tharwat Kareem M. 
Published: September 2024

AbstractThe growing concern and limitations for existing lubricants have driven the need for biolubricants, extensively proposed as the most suitable and sustainable lubricating oils. Biolubricant refers to lubricants that quickly biodegrade and are non-toxic to humans and aquatic habitats. Over the last decade, there has been a significant increase in the production of biolubricants due to the rising demand for replacing petroleum-based lubricants with those derived from renewable sources like vegetable oils and lipase that are used in various applications. In this study biodiesel (FAME) produced from blending animal fats and waste cooking was used as a raw material with ethylene glycol for biolubricant production using a transesterification reaction in the presence of calcium oxide which considers the newest and novel part as there is no production of biolubricant from animal fats and waste cooking oil in previous researches. The reaction parameters of biolubricant production were optimized using response surface methodology (RSM) with the aid of Box Behnken Design (BBD) to study the effect of independent variables on the yield of biolubricant. These variables are temperature ranging from (100–150 °C), reaction time ranging from 1 to 4 h, and FAME (Fatty Acid Methyl Ester) to alcohol molar ratio ranging from (2:1) to (4:1). The highest biolubricant yield is 91.56% at a temperature of 141 °C, a FAME/alcohol molar ratio of 2:1, and 3.3 h. Various analyses were performed on the produced biolubricant at the optimum conditions. The results include a pour point of -9 °C, a flash point of 192 °C, a kinematic viscosity at 40 °C of 10.35 cSt, a viscosity index of 183.6, an ash content of 0.76 wt.%, and a carbon residue of 1.5 wt.%, comparing favorably with the ISO VG 10 standard. The production process of biolubricant was simulated with Aspen Plus version 11 using a Non-Random Two-Liquid (NRTL) fluid package. The simulation results indicated that the production process can be applied on an industrial scale. Economic analysis was performed on the biolubricants production plant. The total capital investment was $12.7 M with a payback period of 1.48 years and an internal rate of return (IRR) of 67.5% indicating the suitability and profitability of the biolubricant production.
The ATOM-Seq sequence capture panel can accurately predict microsatellite instability status in formalin-fixed tumour samples, alongside routine gene mutation testing
Authors: Srihar Kanishta , Gusnanto Arief , Richman Susan D. , West Nicholas P. , Galvin Leanne , Bottomley Daniel , Hemmings Gemma , Glover Amy , Natarajan Subaashini , Miller Rebecca , Arif Sameira , Rossington Hannah , Dunwell Thomas L. , Dailey Simon C. , Fontarum Gracielle , George Agnes , Wu Winnie , Quirke Phil , Wood Henry M. 
Published: September 2024

AbstractMicrosatellite instability (MSI) occurs across a number of cancers and is associated with different clinical characteristics when compared to microsatellite stable (MSS) cancers. As MSI cancers have different characteristics, routine MSI testing is now recommended for a number of cancer types including colorectal cancer (CRC). Using gene panels for sequencing of known cancer mutations is routinely performed to guide treatment decisions. By adding a number of MSI regions to a small gene panel, the efficacy of simultaneous MSI detection in a series of CRCs was tested. Tumour DNA from formalin-fixed, paraffin-embedded (FFPE) tumours was sequenced using a 23-gene panel kit (ATOM-Seq) provided by GeneFirst. The mismatch repair (MMR) status was obtained for each patient from their routine pathology reports, and compared to MSI predictions from the sequencing data. By testing 29 microsatellite regions in 335 samples the MSI status was correctly classified in 314/319 samples (98.4% concordance), with sixteen failures. By reducing the number of regions in silico, comparable performance could be reached with as few as eight MSI marker positions. This test represents a quick, and accurate means of determining MSI status in FFPE CRC samples, as part of a routine gene mutation assay, and can easily be incorporated into a research or diagnostic setting. This could replace separate mutation and MSI tests with no loss of accuracy, thus improving testing efficiency.