bluuebunny/crossref_metadata_2025_split huggingface dataset:
Formação do acervo da academia imperial de belas artes e o papel das comissões de professores
Authors: Godoy Rosani , Thiesen Icléia 
Published: February 2016

<p><strong>Introdução: </strong>O artigo objetiva demonstrar os processos de formação do acervo da Biblioteca da Academia Imperial de Belas Artes (AIBA), analisando a forma como eram realizadas as aquisições e as providências tomadas, caracterizando o que hoje chamaríamos de “política de aquisição de acervo”, pelos dirigentes da AIBA. </p><p><strong>Objetivo: </strong>Evidenciar o papel das Comissões de Professores no processo de seleção do acervo.</p><p><strong>Metodologia:</strong> Centrada na leitura, análise de conteúdo e interpretação de fontes primárias, como ofícios e Relatórios Anuais, datados de 1832 a 1888, enviados pelos dirigentes da AIBA ao Ministro da Educação e Instrução Publica, documentos históricos do arquivo do Museu D. João VI, entre outros.</p><p><strong>Resultados: </strong>Revelam práticas biblioteconômicas sendo realizadas na Biblioteca da AIBA desde o início do século XIX, como a existência de Comissões de Professores que realizavam pareceres sobre as obras a serem incorporadas ao acervo durante o processo de seleção.</p><strong>Conclusões: </strong>A “Política de aquisição”, ao que tudo indica, foi bem-sucedida por ter a AIBA investido na aquisição e no incentivo à doação de obras de interesse à formação do artista e ter como selecionadores diretores e secretários, com o apoio de uma Comissão de Professores, formando artistas de renome que representaram a Arte no país.
Institutions et scolarité : le cas des francophones au Québec vs les Américains d’origine canadienne-française
Authors: Parent Daniel 
Published: February 2016

Environ un million de Canadiens français ont émigré vers les États-Unis entre 1865 et 1930, s’établissant majoritairement dans les États de la Nouvelle-Angleterre. À l’aide de données de recensements américains et canadiens, cette étude examine comment la scolarité et la fréquentation scolaire de leurs descendants se comparent avec ceux de Québécois francophones du même âge. Les données des recensements canadien de 1971 et américain de 1970 nous révèlent que les résidents natifs de la Nouvelle-Angleterre dont la langue maternelle était le français ont profité d’un avantage considérable sur le plan de la scolarité. J’attribue cet écart important à leur accès au système public d’éducation des États-Unis, qui n’avait pas d’équivalent au Québec jusqu’à la fin des années soixante. Ce résultat est encore plus remarquable étant donné la sélection négative présumée en regard de ceux qui quittaient le Québec et le fait que les Franco-Américains réussissaient à reproduire relativement bien les institutions d’enseignement québécoises. En examinant les recensements canadien de 2000 et américain de 2001, on constate que l’écart s’est considérablement résorbé chez les plus jeunes. En fait, contrairement à ce qui est observé en 1971, les jeunes Québécois en 2001 avaient à peu près la même scolarité et étaient au moins aussi susceptibles d’avoir atteint un niveau d’études postsecondaire que les Franco-Américains. Toutefois, ils accusent toujours un retard lorsqu’il s’agit de détenir au moins un baccalauréat. Ce renversement partiel reflète l’effet du « traitement correctif » par lequel le Québec a apporté des changements profonds à ses institutions d’enseignement, particulièrement au niveau postsecondaire, au milieu et à la fin des années soixante.
In‐Silico Nanomedical Exploration of Mefloquine Drug Transport Using Pegylated Graphene Oxide Nanocarrier
Authors: Adekoya Oluwasegun Chijioke , Adekoya Gbolahan Joseph , Sadiku Emmanuel Rotimi , Hamam Yskandar 
Published: September 2024

AbstractThis study investigates the in‐silico transport of mefloquine (MQ) by using graphene oxide (GO) and polyethylene glycol (PEG)‐functionalized GO nanocarriers. Density functional theory (DFT) calculations are performed to explore the molecular interactions, electronic properties, thermodynamics, and release kinetics of MQ‐GO and MQ‐GO/PEG complexes across different phases and environmental conditions. Results indicate a strong affinity between MQ and both types of nanocarriers, with the adsorption energies ranging from −59.14 to −143.16 kcal mol−1, particularly in acidic environments. This suggests a potential for targeted drug delivery in acidic tumor micro‐environments. The incorporation of PEG, enhances stability and compatibility across phases, with chi interaction parameters of between 1.36 and 28.47, and the energy of mixture values, ranging from 0.80 to 16.86 kcal mol−1. The release time of MQ from the nanocarriers, varies significantly, depending on the adsorption energy, and ranges from 2.03 × 1030 to 6.98 × 1091 milliseconds across different phases, highlighting the need for further optimization of the drug delivery systems. The findings of this study provide valuable insights into the design and development of novel nanomedicines, based on MQ and GO nanocarriers, with implications for malaria treatments.
Impact of crop residue removal on crop production, feedstock quality, and theoretical ethanol production in the Mid‐Atlantic United States
Authors: Battaglia Martin L. , Babaei Sirwan , Sadeghpour Amir , Thomason Wade E. , Danish Subhan , Seleiman Mahmoud , Ozlu Ekrem , AL‐Amery Maythem , Fike John H. , Diatta Andre A. 
Published: September 2024

AbstractCellulosic biomass‐to‐bioenergy systems provide fuel, reduce emissions, and offer economic benefits. Corn (Zea mays L.) and wheat (Triticum aestivum L.) residues could be used as feedstocks for biofuel production. However, the impact of residue removal on crop productivity in the Mid‐Atlantic region has not been thoroughly assessed. A trial was conducted to assess crop yield and quality response to different biomass retention rates in grain cropping systems during 2015–2017. Various combinations of corn stover (0–10 Mg ha−1) and wheat straw (0–3 Mg ha−1) were applied in a corn–wheat/soybean [Glycine max (L.) Merr.] rotation in New Kent, VA. In Blacksburg, VA, corn stover (0–20 Mg ha−1) was applied in the continuous corn system. Residues were applied after grain harvest over two production cycles for each system. Residue retention showed no significant impact on grain or crop residue yields or nutrient uptake in either system. Treatment minimally impacted feedstock quality, except wheat straw's sulfur (S) concentration, optimized at around 70% retention in New Kent. Theoretical ethanol potential (TEP) and yield remained unaffected by total residue rates in New Kent. In Blacksburg, over 2 years, a minimum TEP for corn stover corresponded to a retention rate of approximately 30%. A retention rate of more than 30% increased TEP, likely due to improved feedstock quality. Nutrient replacement costs for primary macronutrients and S uptake ranged from $18.3 to $36.9 ha−1 for corn stover and $6.1 to $11.8 ha−1 for wheat straw. Residue harvest or addition did not harm short‐term biomass yield in Virginia's grain‐based cropping systems.
Impact of species selection on plant community, sod tensile strength, and translocation rooting of a pollinator‐garden sod
Authors: Askew Whitnee B. , Godara Navdeep , Brewer John R. , Gonçalves Clebson G. , Goatley Michael , Askew Shawn D. 
Published: September 2024

AbstractInterest in pollinator gardens is increasing to address pollinator decline. The establishment of perennial native plants often takes a few years and establishment projects are often lost to competition from unwanted weedy vegetation. Mature sod of pollinator‐serving, native plants that is free of weeds would be highly desirable to conventional turfgrass sod consumers, thus offering a new revenue stream for traditional sod producers. The objective of this study is to evaluate the influence of four foundational species treatments on 3‐year floral biodiversity of pollinator‐serving plants, sod tensile strength, and transplant rooting strength. Results suggest that polycultures of pollinator‐serving forbs can produce a marketable sod with sufficient tensile strength for lifting and translocating and sufficient ability to establish once relocated. Sod tensile strength, however, is insufficient for lifting when the plant community is not grown over plastic or does not contain a high‐shoot density or rhizomatous foundation species such as hard fescue (Festuca longifolia Thuill.) or common yarrow (Achillea millefolium L.). Unfortunately, adding hard fescue or common yarrow markedly reduces the Shannon diversity index and species richness. The force needed to lift transplanted sod after 3 months was 5553 to 6969 N m−2 regardless of foundation species treatment and was numerically higher than the force reported by previous researchers to lift sod of various turfgrass species. Collectively, the data suggest that the best balance between preserving floral biodiversity and maximizing sod handling integrity would be approached by establishing pollinator‐serving forbs alone or with a blend of native grasses over plastic.
Effects of glyphosate on glyphosate‐resistant maize growth and metabolic parameters in the greenhouse and field
Authors: Bidóia Vitor Simionato , da Costa Yanna Karoline Santos , Gratão Priscila Lupino , Carbonari Caio Antonio , Duke Stephen Oscar , de Carvalho Leonardo Bianco 
Published: September 2024

AbstractThe potential adverse effects of glyphosate on glyphosate‐resistant (GR) crops are still a matter of controversy. The effects of glyphosate at recommended application rates (either a single application of 580 g ae ha−1 of glyphosate at stage V5 or a sequential application of 580 + 980 g ae ha−1 at stage V3 and V7, respectively) on growth, mineral content, and metabolic parameters of GR maize (Zea mays) were determined in greenhouse and field studies, each replicated in different years. No effects on any growth parameter (including grain yield), mineral content (leaf and grain), grain starch, crude protein, or total lipids were found. The only significant negative effect was a slight reduction in tyrosine content of leaf tissue with the sequential treatment, however, there was no increase in shikimic or quinic acids in leaf tissue with any treatment. In a separate greenhouse experiment, there was no sign of oxidative stress, as determined by levels of chlorophylls, carotenoids, and malondialdehyde (MDA) content as well as superoxide dismutase and guaiacol peroxidase activities 4 and 8 days after treatment with 1080 g ha−1 glyphosate. In fact, there was a reduction of MDA in roots of glyphosate‐treated plants 4 DAT, indicating reduced oxidative stress. No aminomethylphosphonic acid, the primary degradation product of glyphosate, was found in either leaves or grain of treated plants, and no glyphosate was found in grain of treated plants from the field studies. All the results are consistent with there being no adverse effects of glyphosate on GR maize at recommended application rates.
Lumen‐apposing metal stents provide early and late clinical benefits for the management of benign gastrointestinal strictures: Is there a role for definitive therapy?
Authors: Pollack Ethan , Norwood Dalton , Caceres Hector , Rapaka Babusai , Perry Isaac E. , Barlass Usman , Mitchell Rachel , McCreight Jessica , Peter Shajan , Mulki Ramzi , Ahmed Ali , Kyanam Kondal , Sánchez‐Luna Sergio A. 
Published: September 2024

AbstractObjectivesThis study aimed to characterize the clinical outcomes, safety, and efficacy of lumen‐apposing metal stents (LAMS) in treating benign gastrointestinal strictures.MethodsA single‐center retrospective review of all patients who underwent LAMS placement for benign strictures from June 2017 to July 2023. Primary outcomes were technical success, early clinical success, late clinical success (LCS), and sustained post‐LAMS clinical success (SPLCS). Secondary outcomes included stent dwell time, stenosis changes, adverse events, reintervention rates, and symptomatology evaluation.ResultsThirty‐five patients underwent placement of 42 LAMS (74% female, mean age: 54.2 ± 11.7 years). Anastomotic strictures accounted for 64% of cases (N = 27, 45% at the gastrojejunal anastomosis). The median STD was 91.0 days (interquartile range [IQR]: 55.0–132.0). Technical success was obtained in all cases. Early clinical successand LCS were achieved in 80% of cases overall. SPLCS was achieved in 45% (n = 15) of cases. The overall reintervention rate was 63%, with a median time to reintervention being 50.5 days (IQR: 24–105). adverse events occurred in 28% (n = 12) overall, with a 24% migration rate (n = 10). Follow‐up was completed in 83% of cases with a median duration of 629 days (range: 192.0–1297.0). Overall symptom improvement occurred in 79% (n = 27) during indwelling LAMS versus 58% and 56% at 30‐ and 60‐days post‐removal, respectively.ConclusionsLAMS for benign gastrointestinal strictures are associated with high technical and early clinical success/LCS rates, positive quality‐of‐life metrics, and a tolerable adverse event rate. Overall, recurrence of symptoms and high reintervention rates post‐LAMS removal reinforce the difficulty in managing benign gastrointestinal strictures but also argue for LAMS as a definitive therapy in select cases.
Exploring potential risk factors for lower limb amputation in people with diabetes—A national observational cohort study in Sweden
Authors: Ramstrand Simon , Carlberg Michael , Jarl Gustav , Johannesson Anton , Hiyoshi Ayako , Jansson Stefan 
Published: September 2024

AbstractAimsRisk factors for lower limb amputation (LLA) in individuals with diabetes have been under‐studied. We examined how 1/demographic and socioeconomic, 2/medical, and 3/lifestyle risk factors may be associated with LLA in people with newly diagnosed diabetes.MethodsUsing the Swedish national diabetes register from 2007 to 2016, we identified all individuals ≥18 years with an incident diabetes diagnosis and no previous amputation. These individuals were followed from the date of diabetes diagnosis to amputation, emigration, death, or the end of the study in 2017 using data from the In‐Patient Register and the Total Population Register. The cohort consisted of 66,569 individuals. Information about demographic, socioeconomic, medical, and lifestyle risk factors was ascertained around the time of the first recorded diabetes diagnosis, derived from the above‐mentioned registers. Cox proportional hazard models were used to obtain hazard ratios (HR) with 95% confidence intervals (CI).ResultsDuring the median follow‐up time of 4 years, there were 133 individuals with LLA. The model adjusting for all variables showed a higher risk for LLA with higher age, HR 1.08 (95% CI 1.05–1.10), male sex, HR 1.57 (1.06–2.34), being divorced, HR 1.67 (1.07–2.60), smokers HR 1.99 (1.28–3.09), insulin treated persons HR 2.03 (1.10–3.74), people with low physical activity (PA) HR 2.05 (1.10–3.74), and people with an increased foot risk at baseline HR > 4.12. People with obesity had lower risk, HR 0.46 (0.29–0.75).ConclusionsThis study found a higher risk for LLA among people with higher age, male sex, who were divorced, had a higher foot risk group, were on insulin treatment, had lower PA levels, and were smokers. No significant association was found between risk for LLA and education level, country of origin, type of diabetes, blood glucose level, hypertension, hyperlipidemia, creatinine level, or glomerular filtration rate. Obesity was associated with lower risk for LLA. Identified variables may have important roles in LLA risk among people with diabetes.
Individual joint contributions to forward propulsion during treadmill walking in women with hip osteoarthritis
Authors: Wade Francesca , Huang Chun‐Hao , Foucher Kharma C. 
Published: September 2024

AbstractAs we age, reliance on the ankle musculature for push‐off during walking reduces and increased reliance on the hip musculature is observed. It is unclear how joint pathology like osteoarthritis may affect this distal‐to‐proximal redistribution of propulsion. Here, we revisited a proof‐of‐concept study to study the effect of split‐belt treadmill training, designed to reduce step length asymmetry, on forward propulsion during walking. Eleven women with hip osteoarthritis and five age‐matched control participants walked on an instrumented split‐belt treadmill at their preferred speed (hip osteoarthritis: 0.73 ± 0.11 m/s; controls: 0.59 ± 0.26 m/s). Women with hip osteoarthritis had less ankle power and propulsive force than controls, and greater hip contributions to forward propulsion on their involved limb. Following split‐belt treadmill training, propulsive force increased on the involved limb. Five of 11 participants experienced a change in redistribution ratio that was greater than the minimal clinically meaningful difference. These “responders” had greater variability in pre‐training redistribution ratio compared to non‐responders. Women with hip osteoarthritis had poorer propulsive gait mechanics than controls yet split‐belt treadmill training improved propulsive force. Redistribution ratio also changed in participants with high baseline variability. Our results suggest that split‐belt treadmill training may be beneficial to people with hip osteoarthritis who have high variability in walking parameters. Further, the age‐related shift to increased hip contributions to propulsion across populations of older adults may be due to increased variability during walking.
Dual and opposing role of retinoic acid receptor signaling in mesenchymal stem cells for tendon ossification in mice
Authors: Isaji Masashi , Kondo Shinya , Nakagawa Takahiro , Ishizaka Takahiro , Amako Masatoshi , Chiba Kazuhiro , Horiuchi Keisuke 
Published: September 2024

AbstractHeterotopic ossification is abnormal bone formation in soft tissues that occurs primarily after injury and major surgery. This condition often causes local pain and limits joint motion in the affected limb. Currently, there is no effective treatment or prophylaxis for this condition other than surgical removal of the lesion. Recent studies suggest that retinoic acid receptor (RAR) agonists are effective in suppressing heterotopic ossification in patients with Fibrodysplasia Ossificans Progressiva, a congenital disorder characterized by progressive ossification of soft tissue, by suppressing the aberrant differentiation of mesenchymal stem cells in muscle. In this study, we aimed to elucidate the potential use of RAR agonists in suppressing injury‐induced ectopic tendon ossification using a mouse Achilles tenotomy model. Contrary to our initial hypothesis, administration of RAR agonists throughout the experimental period (5 weeks) accelerated ectopic tendon ossification in our model. Of note, in vitro differentiation experiments using tendon‐derived mesenchymal stem cells revealed that RAR agonists play opposing roles in osteogenic and chondrogenic differentiation, promoting the former and suppressing the latter. Indeed, we found that RAR agonists suppressed tendon ossification when administered before cartilage nodule formation, but promoted it when administered after. These results suggest that RAR agonists have a dual and opposing effect on tendon ectopic ossification, depending on the duration and timing of their administration. Our data may provide a basis for further investigation of the potential use of RAR agonists in the treatment of injury‐induced heterotopic ossification.
What I was thinking/what I would do differently: Clinical research
Authors: Keane Terence M. , Rauch Sheila A. M. , Bryant Richard A. 
Published: September 2024

AbstractAt the 2023 International Society for Traumatic Stress Studies annual meeting, a panel of three distinguished investigators and clinicians convened to reflect on their careers, their contributions to the field of traumatic stress disorders, and the lessons learned over the years. Dr. Terence M. Keane has guided the development and deployment of evidence‐based care, shaping evaluation guidelines and best treatment practices for traumatic stress pathology. Dr. Sheila Rauch, a pioneer in the development of prolonged exposure therapy, has significantly contributed to the treatment of posttraumatic stress disorder (PTSD) and other traumatic stress disorders. Dr. Richard Bryant has developed targeted psychological treatments for traumatic stress and prolonged grief, adapting to the diverse needs, mechanisms, and cultural contexts of patients. These individuals’ collective experiences span from the establishment of the PTSD diagnosis to the current proliferation of scientific knowledge on its epidemiology, assessment, and treatment. Their unique yet overlapping contributions have provided invaluable guidelines for the next generation of clinicians and investigators. This panel discussion offers a retrospective look at their careers and a forward‐looking perspective on the future of traumatic stress treatment.
Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy
Authors: Longobardi Giuseppe , Moore Thomas Lee , Conte Claudia , Ungaro Francesca , Satchi‐Fainaro Ronit , Quaglia Fabiana 
Published: September 2024

AbstractPolymeric nanoparticles (NPs), specifically those comprised of biodegradable and biocompatible polyesters, have been heralded as a game‐changing drug delivery platform. In fact, poly(α‐hydroxy acids) such as polylactide (PLA), poly(lactide‐co‐glycolide) (PLGA), and poly(ε‐caprolactone) (PCL) have been heavily researched in the past three decades as the material basis of polymeric NPs for drug delivery applications. As materials, these polymers have found success in resorbable sutures, biodegradable implants, and even monolithic, biodegradable platforms for sustained release of therapeutics (e.g., proteins and small molecules) and diagnostics. Few fields have gained more attention in drug delivery through polymeric NPs than cancer therapy. However, the clinical translational of polymeric nanomedicines for treating solid tumors has not been congruent with the fervor or funding in this particular field of research. Here, we attempt to provide a comprehensive snapshot of polyester NPs in the context of chemotherapeutic delivery. This includes a preliminary exploration of the polymeric nanomedicine in the cancer research space. We examine the various processes for producing polyester NPs, including methods for surface‐functionalization, and related challenges. After a detailed overview of the multiple factors involved with the delivery of NPs to solid tumors, the crosstalk between particle design and interactions with biological systems is discussed. Finally, we report state‐of‐the‐art approaches toward effective delivery of NPs to tumors, aiming at identifying new research areas and re‐evaluating the reasons why some research avenues have underdelivered. We hope our effort will contribute to a better understanding of the gap to fill and delineate the future research work needed to bring polyester‐based NPs closer to clinical application.This article is categorized under:
Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
Nanotechnology Approaches to Biology > Nanoscale Systems in Biology
Therapeutic Approaches and Drug Discovery > Emerging Technologies