bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Raven, the Writing-Desk and the Reports: a Sesquicentennial Tale of Nonsense and Law Report Reform
Authors: Million Alison 
Published: December 2015

AbstractIn the 150th anniversary year of both Alice's Adventures in Wonderland and the inception of the Incorporated Council of Law Reporting (ICLR) this article by Alison Million considers any possible common contemporaneous connections between their authors. It makes particular reference to Lewis Carroll's legal associations and his fascination with the processes of law, considering to what extent these may have influenced Alice. In briefly reviewing ICLR history and the instigating factors behind reform it looks at the requisite skills needed finally to devise a successful scheme and any potential overlap between those and some of Lewis Carroll's many subject disciplines. The article concludes that just as the law helped shape Alice, so has Alice contributed to English case law by providing a descriptor for “perfect nonsense”.
FRBR, RDA and Law Libraries
Authors: Doyle Helen 
Published: December 2015

AbstractOver the past few years the cataloguing community has seen radical changes in cataloguing standards, changes which appear to have been largely ignored by legal information professionals. This is a mistake according to Helen Doyle; the new cataloguing model can have enormous implications for the legal community, particularly in the spheres of information and knowledge management, and the profession is missing a huge opportunity by ignoring it. A new cataloguing standard (RDA) has been developed based on an alternative theoretical approach, known as “Functional Requirements for Bibliographic Records” (FRBR). FRBR seeks to change the way we approach the bibliographic universe: from stand-alone, individual repositories of information to networks of linked data built on a structured hierarchy. Commercial law firms are constantly trying to make connections between their traditional resources, online repositories, internal know-how, etc, but struggle to achieve complete synchronicity. FRBR provides a solution to this knowledge management problem: all resources (including people, events and subjects) become searchable, and because everything is linked, users can access information by navigating to it, establishing their own pathway through the data. Moreover, the major legal databases are already utilising linked data in this way – it is time for law firms to catch up.
Moving or Relocating a Library
Authors: Bird Ruth 
Published: December 2015

AbstractIn this article Ruth Bird examines the issues around moving, or relocating, a library. Drawing on her experiences of moving, relocating and renovating, and in the context of current work that is happening at the Bodleian Law Library (BLL), she compares the issues in relation to both law firm libraries and academic libraries. The article examines space management and collection management issues, planning, allocating roles and how the burden of moves can be shared in a collaborative way. Ruth also looks at the ‘people’ issues and the implications for collections.
Basolateral and central amygdala differentially recruit and maintain dorsolateral striatum-dependent cocaine-seeking habits
Authors: Murray Jennifer E. , Belin-Rauscent Aude , Simon Marine , Giuliano Chiara , Benoit-Marand Marianne , Everitt Barry J. , Belin David 
Published: December 2015

AbstractIn the development of addiction, drug seeking becomes habitual and controlled by drug-associated cues, and the neural locus of control over behaviour shifts from the ventral to the dorsolateral striatum. The neural mechanisms underlying this functional transition from recreational drug use to drug-seeking habits are unknown. Here we combined functional disconnections and electrophysiological recordings of the amygdalo-striatal networks in rats trained to seek cocaine to demonstrate that functional shifts within the striatum are driven by transitions from the basolateral (BLA) to the central (CeN) amygdala. Thus, while the recruitment of dorsolateral striatum dopamine-dependent control over cocaine seeking is triggered by the BLA, its long-term maintenance depends instead on the CeN. These data demonstrate that limbic cortical areas both tune the function of cognitive territories of the striatum and thereby underpin maladaptive cocaine-seeking habits.
Flexible thin-film black gold membranes with ultrabroadband plasmonic nanofocusing for efficient solar vapour generation
Authors: Bae Kyuyoung , Kang Gumin , Cho Suehyun K. , Park Wounjhang , Kim Kyoungsik , Padilla Willie J. 
Published: December 2015

AbstractSolar steam generation has been achieved by surface plasmon heating with metallic nanoshells or nanoparticles, which have inherently narrow absorption bandwidth. For efficient light-to-heat conversion from a wider solar spectrum, we employ adiabatic plasmonic nanofocusing to attain both polarization-independent ultrabroadband light absorption and high plasmon dissipation loss. Here we demonstrate large area, flexible thin-film black gold membranes, which have multiscale structures of varying metallic nanoscale gaps (0–200 nm) as well as microscale funnel structures. The adiabatic nanofocusing of self-aggregated metallic nanowire bundle arrays produces average absorption of 91% at 400–2,500 nm and the microscale funnel structures lead to average reflection of 7% at 2.5–17 μm. This membrane allows heat localization within the few micrometre-thick layer and continuous water provision through micropores. We efficiently generate water vapour with solar thermal conversion efficiency up to 57% at 20 kW m−2. This new structure has a variety of applications in solar energy harvesting, thermoplasmonics and related technologies.
Amygdala lesions in rhesus macaques decrease attention to threat
Authors: Dal Monte Olga , Costa Vincent D. , Noble Pamela L. , Murray Elisabeth A. , Averbeck Bruno B. 
Published: December 2015

AbstractEvidence from animal and human studies has suggested that the amygdala plays a role in detecting threat and in directing attention to the eyes. Nevertheless, there has been no systematic investigation of whether the amygdala specifically facilitates attention to the eyes or whether other features can also drive attention via amygdala processing. The goal of the present study was to examine the effects of amygdala lesions in rhesus monkeys on attentional capture by specific facial features, as well as gaze patterns and changes in pupil dilation during free viewing. Here we show reduced attentional capture by threat stimuli, specifically the mouth, and reduced exploration of the eyes in free viewing in monkeys with amygdala lesions. Our findings support a role for the amygdala in detecting threat signals and in directing attention to the eye region of faces when freely viewing different expressions.
Electroporation on microchips: the harmful effects of pH changes and scaling down
Authors: Li Yang , Wu Mengxi , Zhao Deyao , Wei Zewen , Zhong Wenfeng , Wang Xiaoxia , Liang Zicai , Li Zhihong 
Published: December 2015

AbstractElectroporation has been widely used in delivering foreign biomolecules into cells, but there is still much room for improvement, such as cell viability and integrity. In this manuscript, we investigate the distribution and the toxicity of pH changes during electroporation, which significantly decreases cell viability. A localized pH gradient forms between anode and cathode leading to a localized distribution of cell death near the electrodes, especially cathodes. The toxicity of hydroxyl ions is severe and acute due to their effect in the decomposition of phospholipid bilayer membrane. On the other hand, the electric field used for electroporation aggravates the toxicity of hydroxyl because the electropermeabilization of cell membrane makes bilayer structure more loosen and vulnerable. We also investigate the side effects during scaling down the size of electrodes in electroporation microchips. Higher percentage of cells is damaged when the size of electrodes is smaller. At last, we propose an effective strategy to constrain the change of pH by modifying the composition of electroporation buffer. The modified buffer decreases the changes of pH, thus enables high cell viability even when the electric pulse duration exceeds several milliseconds. This ability has potential advantage in some applications that require long-time electric pulse stimulation.
Significance of the double-layer capacitor effect in polar rubbery dielectrics and exceptionally stable low-voltage high transconductance organic transistors
Authors: Wang Chao , Lee Wen-Ya , Kong Desheng , Pfattner Raphael , Schweicher Guillaume , Nakajima Reina , Lu Chien , Mei Jianguo , Lee Tae Hoon , Wu Hung-Chin , Lopez Jeffery , Diao Ying , Gu Xiaodan , Himmelberger Scott , Niu Weijun , Matthews James R. , He Mingqian , Salleo Alberto , Nishi Yoshio , Bao Zhenan 
Published: December 2015

AbstractBoth high gain and transconductance at low operating voltages are essential for practical applications of organic field-effect transistors (OFETs). Here, we describe the significance of the double-layer capacitance effect in polar rubbery dielectrics, even when present in a very low ion concentration and conductivity. We observed that this effect can greatly enhance the OFET transconductance when driven at low voltages. Specifically, when the polar elastomer poly(vinylidene fluoride-co-hexafluoropropylene) (e-PVDF-HFP) was used as the dielectric layer, despite a thickness of several micrometers, we obtained a transconductance per channel width 30 times higher than that measured for the same organic semiconductors fabricated on a semicrystalline PVDF-HFP with a similar thickness. After a series of detailed experimental investigations, we attribute the above observation to the double-layer capacitance effect, even though the ionic conductivity is as low as 10–10 S/cm. Different from previously reported OFETs with double-layer capacitance effects, our devices showed unprecedented high bias-stress stability in air and even in water.
Serum miRNAs panel (miR-16-2*, miR-195, miR-2861, miR-497) as novel non-invasive biomarkers for detection of cervical cancer
Authors: Zhang Yujuan , Zhang Donghong , Wang Fei , Xu Danfei , Guo Ye , Cui Wei 
Published: December 2015

AbstractmiRNAs have been established as critical layer of regulation during tumorigenesis; extracellular miRNAs are extraordinarily stable; and, quantitative reverse transcript polymerase chain reaction (qRT-PCR) provides a sensitive platform for quantifying miRNAs with a broad dynamic range. Herein, we aimed to establish a serum miRNA signature for diagnosing cervical cancer (CC). In this study, we recruited a cohort of 184 CC, 186 cervical intraepithelial neoplasia (CIN) patients and 193 healthy control subjects. qRT-PCR was performed with serum samples to screen a pool of 444 miRNAs at the initial phase, 66 miRNAs at the training phase and 7 miRNAs at the validation phase. The profile of 4 circulating miRNAs (miR-16-2*, miR-195, miR-2861, miR-497) was established for CC diagnosis. By Receiver Operating Characteristic (ROC) curve analysis, this 4-miRNA signature showed high accuracy in discriminating CC (AUC = 0.849) and CIN individuals (AUC = 0.734) from healthy controls. Among these 4 miRNAs, only miR-16-2*, but not miR-195, miR-2861 or miR497, shared a similar pattern in sera of breast cancer and ovarian cancer patients. Overall, our studies have identified a novel noninvasive biomarker constituted with a panel of four miRNAs (miR-16-2*, miR-195, miR-2861, miR-497).
A squeezed light source operated under high vacuum
Authors: Wade Andrew R. , Mansell Georgia L. , Chua Sheon S. Y. , Ward Robert L. , Slagmolen Bram J. J. , Shaddock Daniel A. , McClelland David E. 
Published: December 2015

AbstractNon-classical squeezed states of light are becoming increasingly important to a range of metrology and other quantum optics applications in cryptography, quantum computation and biophysics. Applications such as improving the sensitivity of advanced gravitational wave detectors and the development of space-based metrology and quantum networks will require robust deployable vacuum-compatible sources. To date non-linear photonics devices operated under high vacuum have been simple single pass systems, testing harmonic generation and the production of classically correlated photon pairs for space-based applications. Here we demonstrate the production under high-vacuum conditions of non-classical squeezed light with an observed 8.6 dB of quantum noise reduction down to 10 Hz. Demonstration of a resonant non-linear optical device, for the generation of squeezed light under vacuum, paves the way to fully exploit the advantages of in-vacuum operations, adapting this technology for deployment into new extreme environments.
No association between HPV positive breast cancer and expression of human papilloma viral transcripts
Authors: Gannon Orla M. , Antonsson Annika , Milevskiy Michael , Brown Melissa A. , Saunders Nicholas A. , Bennett Ian C. 
Published: December 2015

AbstractInfectious agents are thought to be responsible for approximately 16% of cancers worldwide, however there are mixed reports in the literature as to the prevalence and potential pathogenicity of viruses in breast cancer. Furthermore, most studies to date have focused primarily on viral DNA rather than the expression of viral transcripts. We screened a large cohort of fresh frozen breast cancer and normal breast tissue specimens collected from patients in Australia for the presence of human papilloma virus (HPV) DNA, with an overall prevalence of HPV of 16% and 10% in malignant and non-malignant tissue respectively. Samples that were positive for HPV DNA by nested PCR were screened by RNA-sequencing for the presence of transcripts of viral origin, using three different bioinformatic pipelines. We did not find any evidence for HPV or other viral transcripts in HPV DNA positive samples. In addition, we also screened publicly available breast RNA-seq data sets for the presence of viral transcripts and did not find any evidence for the expression of viral transcripts (HPV or otherwise) in other data sets. This data suggests that transcription of viral genomes is unlikely to be a significant factor in breast cancer pathogenesis.
Sex differences in social modulation of learning in rats
Authors: Mikosz Marta , Nowak Aleksandra , Werka Tomasz , Knapska Ewelina 
Published: December 2015

AbstractIn its simplest form, empathy can be characterized as the capacity to share the emotional experiences among individuals, a phenomenon known as emotional contagion. Recent research shows that emotional contagion and its adaptive role can be studied in rodents. However, it is not known whether sex differences observed in human empathy extend to its more primitive forms. In the present study, we used a rat model of emotional contagion to compare the behavioral consequences of social transfer of information about threat and the subsequent neural activation patterns in male and female rats. We found that: (1) males and females display a similar behavioral pattern during the interaction with either a fear-conditioned or a control rat; (2) interaction with a fear-conditioned conspecific positively modulates two-way avoidance learning in male and diestral female rats but not in estral females; and (3) such interaction results in increased c-Fos expression in the central and lateral nuclei of the amygdala and the prelimbic and infralimbic cortex in males, whereas in females no such changes were observed. Collectively, our results point to the occurrence of sex and estrus cycle phase differences in susceptibility to emotional contagion and underlying neuronal activation in rodents.
Enhanced exchange bias and improved ferromagnetic properties in Permalloy–BiFe0.95Co0.05O3 core–shell nanostructures
Authors: Javed K. , Li W. J. , Ali S. S. , Shi D. W. , Khan U. , Riaz S. , Han X. F. 
Published: December 2015

AbstractHybrid core–shell nanostructures consisting of permalloy (Ni80Fe20) and multiferroic(BiFeO3, BFO/BiFe0.95Co0.05O3, BFC) materials were synthesized by a two-step method, based on wet chemical impregnation and subsequent electrodeposition within porous alumina membranes. Structural and magnetic characterizations have been done to investigate doping effect on magnetic properties and exchange bias. The magnetometry analysis revealed significant enhancements of the exchange bias and coercivity in NiFe-BFC core-shell nanostructures as compared with NiFe-BFO core-shell nanostructures. The enhancements can be attributed to the effective reduction of ferromagnet domain sizes between adjacent layers of core-shell structure. It indicates that it is possible to improve properties of multiferroic composites by site-engineering method. Our approach opens a pathway to obtain optimized nanostructured multiferroic composites exhibiting tunable magnetic properties.
Anti-inflammatory effects of Perilla frutescens in activated human neutrophils through two independent pathways: Src family kinases and Calcium
Authors: Chen Chun-Yu , Leu Yann-Lii , Fang Yu , Lin Chwan-Fwu , Kuo Liang-Mou , Sung Wei-Che , Tsai Yung-Fong , Chung Pei-Jen , Lee Ming-Chung , Kuo Yu-Ting , Yang Hsuan-Wu , Hwang Tsong-Long 
Published: December 2015

AbstractThe leaves of Perilla frutescens (L.) Britt. have been traditionally used as an herbal medicine in East Asian countries to treat a variety diseases. In this present study, we investigated the inhibitory effects of P. frutescens extract (PFE) on N-formyl-Met-Leu-Phe (fMLF)-stimulated human neutrophils and the underlying mechanisms. PFE (1, 3 and 10 μg/ml) inhibited superoxide anion production, elastase release, reactive oxygen species formation, CD11b expression and cell migration in fMLF-activated human neutrophils in dose-dependent manners. PFE inhibited fMLF-induced phosphorylation of the Src family kinases (SFKs), Src (Tyr416) and Lyn (Tyr396) and reduced their enzymatic activities. Both PFE and PP2 (a selective inhibitor of SFKs) reduced the phosphorylation of Burton’s tyrosine kinases (Tyr223) and Vav (Tyr174) in fMLF-activated human neutrophils. Additionally, PFE decreased intracellular Ca2+ levels ([Ca2+]i), whereas PP2 prolonged the time required for [Ca2+]i to return to its basal level. Our findings indicated that PFE effectively regulated the inflammatory activities of fMLF-activated human neutrophils. The anti-inflammatory effects of PFE on activated human neutrophils were mediated through two independent signaling pathways involving SFKs (Src and Lyn) and mobilization of intracellular Ca2+.
Combination of NTP with cetuximab inhibited invasion/migration of cetuximab-resistant OSCC cells: Involvement of NF-κB signaling
Authors: Chang Jae Won , Kang Sung Un , Shin Yoo Seob , Seo Seong Jin , Kim Yeon Soo , Yang Sang Sik , Lee Jong-Soo , Moon Eunpyo , Lee Keunho , Kim Chul-Ho 
Published: December 2015

AbstractAlthough the epidermal growth factor receptor (EGFR) is an established target in head-and-neck cancer (HNC), resistance to EGFR-targeted therapy mediated by various mechanisms has been reported. Therefore, a combination strategy to overcome resistance to EGFR mono-targeted therapy is clinically required. We have previously demonstrated that non-thermal atmospheric pressure plasma (NTP) induces death of various cancer cells, including oral squamous cancer (OSCC) cells. In this study, we report for the first time that combining NTP treatment with cetuximab led to inhibition of migration and invasion in cetuximab-resistant OSCC cells, which could be a promising strategy to overcome resistance to anti-EGFR therapy. NTP induced deactivation of NF-κB in SCCQLL1 cells, but not in MSKQLL1 cells. In addition, NTP increased the expression level of E-cadherin and decreased those of vimentin, Slug, Snail, matrix metalloproteinase (MMP)-2, -9 and activities of MMPs. Moreover, NF-κB upregulation using cDNA diminished the combination effect of NTP on invasion, migration and related signals. Taken together, these results indicate that the combination of NTP with cetuximab can decrease invasiveness in cetuximab-resistant OSCCs through a novel mechanism involving the NF-κB pathway. These findings show the therapeutic potential of treatment that combines NTP and cetuximab in OSCC.
Blood lead level and its association with body mass index and obesity in China - Results from SPECT-China study
Authors: Wang Ningjian , Chen Chi , Nie Xiaomin , Han Bing , Li Qin , Chen Yi , Zhu Chunfang , Chen Yingchao , Xia Fangzhen , Cang Zhen , Lu Meng , Meng Ying , Zhai Hualing , Lin Dongping , Cui Shiyong , Jensen Michael D. , Lu Yingli 
Published: December 2015

AbstractWe aimed to report environmental and blood lead level (BLL) in China and investigate the relationship of BLL with body mass index (BMI) and obesity. 5558 subjects were enrolled from 16 sites in China. BLL was measured by atomic absorption spectrometry. Obesity was defined as BMI ≥ 30 kg/m2. Median (interquartile range) of BLL was 44.00 μg/L (29.00–62.16) for men and 37.79 μg/L (25.13–54.35) for women, about twice higher than in U.S. population. Subjects in rural and high-economic-status areas had significantly greater BLL (P < 0.001). However, in these areas, the lead levels in drinking water, river water and rice were comparable to or significantly lower than those in urban and low-economic-status areas. After adjustment for age, urbanization, economic status and metabolic factors, BLL was independently associated with BMI in women (Pfor trend < 0.001), but not in men. In fully adjusted model, increased quartiles of BLL were associated with significantly increased odds ratios of obesity (Pfor trend < 0.01) in women. In conclusion, BLLs in Chinese adults were much higher than in developed countries. There was a sex-specific association between BLL and BMI. Elevated BLL does not appear to be associated with lead levels in drinking water or rice, suggesting some other exposure source.
The Saccharomyces cerevisiae poly(A) binding protein Pab1 as a target for eliciting stress tolerant phenotypes
Authors: Martani Francesca , Marano Francesca , Bertacchi Stefano , Porro Danilo , Branduardi Paola 
Published: December 2015

AbstractWhen exploited as cell factories, Saccharomyces cerevisiae cells are exposed to harsh environmental stresses impairing titer, yield and productivity of the fermentative processes. The development of robust strains therefore represents a pivotal challenge for the implementation of cost-effective bioprocesses. Altering master regulators of general cellular rewiring represents a possible strategy to evoke shaded potential that may accomplish the desirable features. The poly(A) binding protein Pab1, as stress granules component, was here selected as the target for obtaining widespread alterations in mRNA metabolism, resulting in stress tolerant phenotypes. Firstly, we demonstrated that the modulation of Pab1 levels improves robustness against different stressors. Secondly, the mutagenesis of PAB1 and the application of a specific screening protocol on acetic acid enriched medium allowed the isolation of the further ameliorated mutant pab1 A60-9. These findings pave the way for a novel approach to unlock industrially promising phenotypes through the modulation of a post-transcriptional regulatory element.