bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brief Report: Power Doppler Ultrasonography for Detection of Increased Vascularity in the Fascia: A Potential Early Diagnostic Tool in Fasciitis of Dermatomyositis
Authors: Yoshida Ken , Nishioka Makiko , Matsushima Satoshi , Joh Kensuke , Oto Yosuke , Yoshiga Masayuki , Otani Kazuhiro , Ito Haruyasu , Hirai Kenichiro , Furuya Kazuhiro , Ukichi Taro , Noda Kentaro , Kingetsu Isamu , Kurosaka Daitaro 
Published: July 2016

ObjectiveWe previously demonstrated that fasciitis is a common lesion of dermatomyositis (DM) that is detectable early after disease onset by en bloc muscle biopsy combined with magnetic resonance imaging (MRI). Power Doppler ultrasonography (PDUS) is a useful method for detection of inflammation and vascularity in rheumatic diseases. We undertook this study to determine whether fasciitis was detectable by PDUS in patients with DM.MethodsWe prospectively evaluated 7 patients with DM and 7 patients with polymyositis (PM) for the detection of fasciitis with PDUS. MRI and PDUS were both performed in all patients. Fasciitis was histologically confirmed by en bloc biopsy.ResultsAmong all patients with DM, 4 showed signs of fasciitis on MRI, while increased blood flow signals were observed along the fascia by PDUS in 6 DM patients, including 4 patients with early disease (<2 months after the onset of muscle symptoms). Histologically, significant fasciitis was confirmed in 4 patients with DM. In the remaining 3 patients with DM, significant fasciitis was not evident histologically, but mild proliferation of capillaries and mild inflammation were notable in the area of the fascia. Immunohistochemical staining for CD31 indicated abnormal neovascular proliferation in the fascia in patients with DM. None of the PM patients showed signs of fasciitis or increased vascularity by MRI, PDUS, or en bloc biopsy.ConclusionIn our limited population, PDUS was useful for the detection of fasciitis associated with DM, especially in the early stage of disease. The increased blood flow signal as detected by PDUS is involved in angiogenesis accompanying fasciitis in patients with DM.
Brief Report: Dialister as a Microbial Marker of Disease Activity in Spondyloarthritis
Authors: Tito Raul Y. , Cypers Heleen , Joossens Marie , Varkas Gaëlle , Van Praet Liesbet , Glorieus Elien , Van den Bosch Filip , De Vos Martine , Raes Jeroen , Elewaut Dirk 
Published: July 2016

ObjectiveDysbiosis of the intestinal microbiota has been widely established in inflammatory bowel disease (IBD). There is significant clinical and genetic overlap between spondyloarthritis (SpA) and IBD, and up to 50% of all patients with SpA exhibit microscopic signs of bowel inflammation, often bearing particular resemblance to early Crohn's disease, a subtype of IBD. This study was undertaken to assess the relationship between intestinal microbial composition, gut histology, and disease activity markers in SpA.MethodsGene analysis by 16S ribosomal RNA amplicon sequencing was used to compare the microbial composition in ileal and colonic biopsy specimens from 27 patients with SpA (14 with microscopic bowel inflammation, 13 without) and 15 healthy control subjects (ileal samples from all 15 subjects and colonic samples from 6). Spearman's rank correlation tests were used to assess correlations of the microbial composition with disease activity measures.ResultsThe intestinal inflammation status (histologically normal versus acute or chronic inflammation) was strongly associated with the mucosal microbiota profile of patients with SpA. In inflamed biopsy tissue, the detected bacterial community composition clustered separately from that in noninflamed biopsy tissue (P < 0.05 by permutational multivariate analysis of variance, using hierarchical clustering on Bray–Curtis distances). Interestingly, abundance of the genus Dialister was found to be positively correlated with the Ankylosing Spondylitis Disease Activity Score (Spearman's rho = 0.62, false discovery rate–corrected q < 0.01). This finding was further supported by the low frequency of Dialister observed in noninflamed ileal and colonic biopsy tissue from patients with SpA and healthy controls.ConclusionThese findings demonstrate a significant difference in the intestinal microbial composition in patients with SpA who have microscopic gut inflammation compared to those without microscopic gut inflammation. Moreover, Dialister may represent a potential microbial marker of disease activity in SpA.
Post Hoc Analysis of the Phase II/III APRIL‐SLE Study: Association Between Response to Atacicept and Serum Biomarkers Including BLyS and APRIL
Authors: Gordon Caroline , Wofsy David , Wax Stephen , Li Yong , Pena Rossi Claudia , Isenberg David 
Published: July 2016

ObjectiveTo assess the relationship between treatment response, baseline biomarker levels, and atacicept exposure in patients with systemic lupus erythematosus (SLE) in the phase II/III APRIL‐SLE study.MethodsWe performed a post hoc analysis of patients who received placebo, atacicept 75 mg, or atacicept 150 mg in a randomized, controlled, 52‐week trial. Serum levels of BlyS and APRIL were measured at baseline, and serum levels of Ig and the numbers of naive B cells and plasma cells were measured at baseline and during treatment. Atacicept exposure was determined by assessment of the serum trough concentrations throughout the 52‐week trial period. Associations between these parameters, treatment response (reduction in British Isles Lupus Assessment Group A or B flare), and infection rates were explored.ResultsRecurrent high baseline levels of both BLyS (≥1.6 ng/ml) and APRIL (≥2.2 ng/ml) correlated with a greater treatment response (flare rate 75.7% with placebo, and 50.0% and 32.0% with atacicept 75 mg and atacicept 150 mg, respectively) compared with lower baseline levels of both. Increased atacicept exposure correlated with reduced flare rates (60.5% with placebo; 63.4%, 61.0%, 48.8%, and 29.3% in the 4 quartiles, from lowest to highest atacicept exposure). Greater pharmacodynamic responses (reduced Ig levels and naive B cell and plasma cell numbers) were associated with greater reductions in the flare rate. Infection rates were similar regardless of biomarker levels at baseline or at the time of atacicept exposure.ConclusionThese post hoc analyses demonstrate a dose‐response relationship between atacicept concentrations, reduced Ig levels, and reduced flare rates and suggest that baseline biomarkers such as elevated serum levels of BLyS and APRIL may help to identify the patients who are most likely to benefit from atacicept treatment.
A Multifunctional Biomaterial with NIR Long Persistent Phosphorescence, Photothermal Response and Magnetism
Authors: Wu Yiling , Li Yang , Qin Xixi , Qiu Jianrong 
Published: July 2016

AbstractThere are many reports on long persistent phosphors (LPPs) applied in bioimaging. However, there are few reports on LPPs applied in photothermal therapy (PTT), and an integrated system with multiple functions of diagnosis and therapy. In this work, we fabricate effective multifunctional phosphors Zn3Ga2SnO8: Cr3+, Nd3+, Gd3+ with NIR persistent phosphorescence, photothermal response and magnetism. Such featured materials can act as NIR optical biolabels and magnetic resonance imaging (MRI) contrast agents for tracking the early cancer cells, but also as photothermal therapeutic agent for killing the cancer cells. This new multifunctional biomaterial is expected to open a new possibility of setting up an advanced imaging‐guided therapy system featuring a high resolution for bioimaging and low side effects for the photothermal ablation of tumors.
Maternal gene–micronutrient interactions related to one‐carbon metabolism and the risk of myelomeningocele among offspring
Authors: Nguyen Margaret P. , Lupo Philip J. , Northrup Hope , Morrison Alanna C. , Cirino Paul T. , Au Kit Sing 
Published: July 2016

BackgroundFew studies have evaluated interactions between maternal genetic variation in 5,10‐methylenetetrahydrofolate reductase (MTHFR) and micronutrient intake on the risk of myelomeningocele (MM) in offspring. Therefore, we sought to determine if the role of maternal MTHFR C677T and A1298C on MM risk is altered by maternal intake of micronutrients related to one‐carbon metabolism.MethodsThe study consisted of 220 MM case–parent trios recruited from 1996 to 2006. A dietary questionnaire was used to obtain information on maternal dietary intake on eight micronutrients including folate and cobalamin. TaqMan assays were used to generate MTHFR C677T and A1298C genotypes. Log‐linear models were used to evaluate the joint effects of maternal genotype and micronutrient intake dichotomized as at or above versus below the United States Recommended Dietary Allowance (US RDA) on MM.ResultsThere was little evidence to suggest maternal MTHFR genotypes interacted with micronutrient intake to influence the risk of MM. For instance, the effect of MTHFR 677T was similar for mothers with cobalamin intake below US RDA (relative risk [RR] = 0.97) versus at or above US RDA cobalamin intake (RR = 0.81, interaction p = 0.87). However, some differences were noted. For example, the effect of MTHFR 1298C appeared to be different between those mothers below US RDA folate intake (RR = 0.98) versus those at or above US RDA folate intake (RR = 0.68), but the interaction was not statistically significant (interaction p = 0.27).ConclusionThere did not appear to be strong effects of maternal micronutrient intake on the role of maternal genetic polymorphisms in MTHFR C677T and A1298C on MM risk. Birth Defects Research 109:99–105, 2017. © 2016 Wiley Periodicals, Inc.
Experimental and molecular docking investigation on DNA interaction of N‐substituted phthalimides: antibacterial, antioxidant and hemolytic activities
Authors: Nayab Pattan Sirajuddin , Irfan Mohammad , Abid Mohammad , Pulaganti Madhusudana , Nagaraju Chinthakunta , Chitta Suresh Kumar , Rahisuddin  
Published: July 2016

AbstractA series of Schiff base molecules derived from a phthalimide scaffold was investigated as efficient antibacterial, antioxidant and DNA‐interacting agents. The spectroscopic characterization of these derivatives was studied in detail using elemental analysis and spectroscopic techniques. The DNA‐binding profile of title molecules against Ct‐DNA (calf thymus) was investigated by absorbance, fluorescence, hydrodynamics and thermal denaturation investigations. The bacterial inhibition potential of these molecules was investigated against Escherichia coli and Staphylococcus aureus. Molecule 3c emerged as the most active against S. aureus (IC50: 14.8 μg/mL), whereas compounds 3a and 3b displayed potential antibacterial activities against E. coli (IC50: 49.7 and 67.6 μg/mL). Molecular docking studies of these compounds against GlcN‐6‐P synthase were carried out to rationalize antibacterial efficiency of these molecules. These newly synthesized molecules were screened for their scavenging capacity against 2,2‐diphenyl‐1‐picryl‐hydrazyl (DPPH) and H2O2 free radicals and the results were compared with ascorbic acid as synthetic antioxidant. The title molecules 3a, 3b and 3e showed less than 20% hemolysis, which indicated their significant non‐toxic behavior.
Biofunctionalizing nanofibers with carbohydrate blood group antigens
Authors: Barr Katie , Kannan Bhuvaneswari , Korchagina Elena , Popova Inna , Ryzhov Ivan , Henry Stephen , Bovin Nicolai 
Published: July 2016

AbstractA rapid and simple method of biofunctionalising nylon, cellulose acetate, and polyvinyl butyral electrospun nanofibers with blood group glycans was achieved by preparing function‐spacer‐lipid constructs and simply contacting them to fibers with a piezo inkjet printer. A series of water dispersible amphipathic glycan‐spacer constructs were synthesized representing a range ABO and related blood group antigens. After immediate contact of the amphipathic glycan‐spacer constructs with nanofiber surfaces they self‐assembled and were detectable by enzyme immunoassays with high sensitivity and specificity.
Leukocyte telomere length in relation to the risk of Barrett's esophagus and esophageal adenocarcinoma
Authors: Wennerström E. Christina M. , Risques Rosa A. , Prunkard Donna , Giffen Carol , Corley Douglas A. , Murray Liam J. , Whiteman David C. , Wu Anna H. , Bernstein Leslie , Ye Weimin , Chow Wong‐Ho , Vaughan Thomas L. , Liao Linda M. 
Published: July 2016

AbstractChronic inflammation and oxidative damage caused by obesity, cigarette smoking, and chronic gastroesophageal reflux disease (GERD) are major risk factors associated with Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). EAC has been increasing the past few decades, and early discovery and treatment are crucial for survival. Telomere shortening due to cell division and oxidative damage may reflect the impact of chronic inflammation and could possibly be used as predictor for disease development. We examined the prevalence of shorter leukocyte telomere length (LTL) among individuals with GERD, BE, or EAC using a pooled analysis of studies from the Barrett's and Esophageal Adenocarcinoma Consortium (BEACON). Telomere length was measured in leukocyte DNA samples by Q‐PCR. Participants included 1173 patients (386 with GERD, 384 with EAC, 403 with BE) and 736 population‐based controls. The association of LTL (in tertiles) along the continuum of disease progression from GERD to BE to EAC was calculated using study‐specific odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models adjusted for potential confounders. Shorter LTL were less prevalent among GERD patients (OR 0.57; 95% CI: 0.35–0.93), compared to population‐based controls. No statistically significant increased prevalence of short/long LTL among individuals with BE or EAC was observed. In contrast to some earlier reports, our findings add to the evidence that leukocyte telomere length is not a biomarker of risk related to the etiology of EAC. The findings do not suggest a relationship between LTL and BE or EAC.
Reverse Transcription of Threose Nucleic Acid by a Naturally Occurring DNA Polymerase
Authors: Dunn Matthew R. , Chaput John C. 
Published: July 2016

AbstractRecent advances in polymerase engineering have enabled the replication of xenonucleic acid (XNA) polymers with backbone structures distinct from those found in nature. By introducing a selective amplification step into the replication cycle, functional XNA molecules have been isolated by in vitro selection with binding and catalytic activity. Despite these successes, coding and decoding genetic information in XNA polymers remains limited by the fidelity and catalytic efficiency of engineered XNA polymerases. In particular, the process of reverse transcribing XNA back into DNA for amplification by PCR has been problematic. Here, we show that Geobacillus stearothermophilus (Bst) DNA polymerase I functions as an efficient and faithful threose nucleic acid (TNA)‐dependent DNA polymerase. Bst DNA polymerase generates ∼twofold more cDNA with threefold fewer mutations than Superscript II (SSII), which was previously the best TNA reverse transcriptase. Notably, Bst also functions under standard magnesium‐dependent conditions, whereas SSII requires manganese ions to relax the enzyme's substrate specificity. We further demonstrate that Bst DNA polymerase can support the in vitro selection of TNA aptamers by evolving a TNA aptamer to human α‐thrombin.
Imidazolyl‐Functionalized Ordered Mesoporous Polymer from Nanocasting as an Effective Support for Highly Dispersed Palladium Nanoparticles in the Heck Reaction
Authors: Karimi Babak , Marefat Mohammad Reza , Hasannia Maliheh , Akhavan Pari Fadavi , Mansouri Fariborz , Artelli Zahra , Mohammadi Fariba , Vali Hojatollah 
Published: July 2016

AbstractNew imidazolyl‐functionalized ordered mesoporous cross‐linked polymers were prepared by the copolymerization of the ionic liquid 3‐benzyl‐1‐vinyl‐1H‐imidazolium bromide with divinylbenzene as the cross‐linker and azobisisobutyronitrile as the radical initiator in the presence of O‐silylated SBA‐15 as the hard template. The materials were characterized by N2 adsorption–desorption analysis, TEM, thermogravimetric analysis, elemental analysis, and FTIR spectroscopy. The material, which benefits from the use of entrapped ionic liquid in the prepared polymer matrix in combination with its ordered mesoporous structure, is an excellent environment for the stabilization of highly dispersed Pd nanoparticles to result in a recyclable catalyst system with a significant activity in the Heck coupling reaction of aryl halides. The presence of well‐distributed imidazolium functionalities in the polymeric framework might be responsible for the relatively uniform and nearly atomic scale distribution of Pd nanoparticles throughout the mesoporous structure and the prevention of Pd agglomeration during the reaction, which results in high durability, high stability, and good recycling characteristics of the catalyst. Although our catalyst system operates in a homogeneous pathway, it is also very stable and recyclable.
The Role of Ate Complexes in the Copper‐Mediated Trifluoromethylation of Alkynes
Authors: Weske Sebastian , Schoop Ramona , Koszinowski Konrad 
Published: July 2016

AbstractTrifluoromethylation reactions have recently received increased attention because of the beneficial effect of the trifluoromethyl group on the pharmacological properties of numerous substances. A common method to introduce the trifluoromethyl group employs the Ruppert–Prakash reagent, that is, Si(CH3)3CF3, together with a copper(I) halide. We have applied this method to the trifluoromethylation of aromatic alkynes and used electrospray‐ionization mass spectrometry to investigate the mechanism of these reactions in tetrahydrofuran, dichloromethane, and acetonitrile as well as with and without added 1,10‐phenanthroline. In the absence of the alkyne component, the homoleptic ate complexes [Cu(CF3)2]− and [Cu(CF3)4]− were observed. In the presence of the alkynes RH, the heteroleptic complexes [Cu(CF3)3R]− were detected as well. Upon gas‐phase fragmentation, these key intermediates released the cross‐coupling products R−CF3 with perfect selectivity. Apparently, the [Cu(CF3)3R]− complexes did not originate from homoleptic cuprate anions, but from unobservable neutral precursors. The present results moreover point to the involvement of oxygen as the oxidizing agent.
Windmill Co4{Co4(μ4‐O)} with 16 Divergent Branches Forming a Family of Metal–Organic Frameworks: Organic Metrics Control Topology, Gas Sorption, and Magnetism
Authors: Chen Qing , Xue Wei , Lin Jian‐Bin , Wei Yong‐Sheng , Yin Zheng , Zeng Ming‐Hua , Kurmoo Mohamedally , Chen Xiao‐Ming 
Published: July 2016

AbstractA series of highly connected metal–organic frameworks (MOFs), [Co8(O)(OH)4(H2O)4(ina)8](NO3)2⋅2 C2H5OH⋅4 H2O (1), [Co8(O)(OH)4(H2O)4(pba)8](NO3)2⋅8 C2H5OH⋅28 H2O (2), and [Co8(O)(OH)4(H2O)4(pbba)8](NO3)2⋅guest (3), in which ina=isonicotinate, pba=4‐pyridylbenzoate, and pbba=4‐(pyridine‐4‐yl)phenylbenzoate, is reported. These MOFs contain a new secondary building unit (SBU), with a square Co4(μ4‐O) central unit having the rare μ4‐O2− motif, which is decorated by the other four peripheral cobalt atoms through μ3‐OH in a windmill‐like shape. This SBU holds 16 divergent connecting organic ligands, pyridyl‐carboxylates, to form three different frameworks. The high porosity of desolvated 2 is shown by the efficient gas absorption of N2, CO2, CH4, and H2. In addition, 1 and 2 exhibit unusual canted antiferromagnetic behavior with spin‐glass‐like relaxation, with blocking temperatures that are fairly high, 20 K (1) and 10 K (2), for cobalt materials. The relationship between the metal clusters and linkers has been studied, in which the size and rotational degrees of freedom of the ligands are found to control the topology, gas sorption, and magnetic properties.
Metal‐Catalyzed Cyclization Reactions of 2,3,4‐Trien‐1‐ols: A Joint Experimental–Computational Study
Authors: Alcaide Benito , Almendros Pedro , Cembellín Sara , Fernández Israel , Martínez del Campo Teresa 
Published: July 2016

AbstractControlled preparation of tri‐ and tetrasubstituted furans, as well as carbazoles has been achieved through chemo‐ and regioselective metal‐catalyzed cyclization reactions of cumulenic alcohols. The gold‐ and palladium‐catalyzed cycloisomerization reactions of cumulenols, including indole‐tethered 2,3,4‐trien‐1‐ols, to trisubstituted furans was effective, due to a 5‐endo‐dig oxycyclization by attack of the hydroxy group onto the central cumulene double bond. In contrast, palladium‐catalyzed heterocyclization/coupling reactions with 3‐bromoprop‐1‐enes furnished tetrasubstituted furans. Also studied was the palladium‐catalyzed cyclization/coupling sequence involving protected indole‐tethered 2,3,4‐trien‐1‐ols and 3‐bromoprop‐1‐enes that exclusively generated trisubstituted carbazole derivatives. These results could be explained through a selective 6‐endo‐dig cumulenic hydroarylation, followed by aromatization. DFT calculations were carried out to understand this difference in reactivity.
Light Harvesting and White‐Light Generation in a Composite of Carbon Dots and Dye‐Encapsulated BSA‐Protein‐Capped Gold Nanoclusters
Authors: Barman Monoj Kumar , Paramanik Bipattaran , Bain Dipankar , Patra Amitava 
Published: July 2016

AbstractSeveral strategies have been adopted to design an artificial light‐harvesting system in which light energy is captured by peripheral chromophores and it is subsequently transferred to the core via energy transfer. A composite of carbon dots and dye‐encapsulated BSA‐protein‐capped gold nanoclusters (AuNCs) has been developed for efficient light harvesting and white light generation. Carbon dots (C‐dots) act as donor and AuNCs capped with BSA protein act as acceptor. Analysis reveals that energy transfer increases from 63 % to 83 % in presence of coumarin dye (C153), which enhances the cascade energy transfer from carbon dots to AuNCs. Bright white light emission with a quantum yield of 19 % under the 375 nm excitation wavelength is achieved by changing the ratio of components. Interesting findings reveal that the efficient energy transfer in carbon‐dot–metal‐cluster nanocomposites may open up new possibilities in designing artificial light harvesting systems for future applications.
ChemInform Abstract: Electronic, Crystal Chemistry, and Nonlinear Optical Property Relationships in the Dugganite A3B3CD2O14 Family.
Authors: Yu Hongwei , Young Joshua , Wu Hongping , Zhang Weiguo , Rondinelli James M. , Halasyamani P. Shiv 
Published: July 2016

AbstractThe nonlinear optical (NLO) materials Sr3Zn3TeP2O14, Ba3Zn3TeP2O14, Pb3Mg3TeP2O14, Pb3Zn3TeP2O14, Pb3Zn3WP2O14, and Pb3Zn3VP2O14 are prepared by solid state reactions of stoichiometric mixtures of alkaline earth carbonates, metal oxides, H2TeO4, and NH4H2PO4 (Pt crucible, 1.
ChemInform Abstract: Stabilization of HfB12 in Y1‐xHfxB12 under Ambient Pressure.
Authors: Akopov Georgiy , Yeung Michael T. , Turner Christopher L. , Li Rebecca L. , Kaner Richard B. 
Published: July 2016

AbstractThe high‐pressure HfB12 phase is stabilized in the Y1‐xHfxB12 (x = 0.00, 0.05, 0.25, 0.50, 0.75, 0.95) system (obtained by arc‐melting of the elements) under ambient pressure.
ChemInform Abstract: Tuning Complexity by Lithiation: A Family of Intergrowth Structures Using Condensed hypho‐Icosahedra in the Li‐Doped Ca—Zn System.
Authors: Lin Qisheng , Zhu Ran , Miller Gordon J. 
Published: July 2016

AbstractThe new intermetallic structures Ca12LixZn59‐x (x = 5.65—14.95) and Ca15Li19.07Zn55.93 are found to exist in the Ca—Li—Zn system.
ChemInform Abstract: Mixed‐Valent NaCu4Se3: A Two‐Dimensional Metal.
Authors: Sturza Mihai , Bugaris Daniel E. , Malliakas Christos D. , Han Fei , Chung Duck Young , Kanatzidis Mercouri G. 
Published: July 2016

AbstractThe new title compound is synthesized in quantitative yield by solid state reaction of a stoichiometric mixture of CuSe, Cu2Se, and Na (alumina crucible, 800 °C, 24 h, followed by annealing at 600 °C for 3 d).