bluuebunny/crossref_metadata_2025_split huggingface dataset:
Budget of organic carbon in the North‐Western Mediterranean open sea over the period 2004–2008 using 3‐D coupled physical‐biogeochemical modeling
Authors: Ulses C. , Auger P.‐A. , Soetaert K. , Marsaleix P. , Diaz F. , Coppola L. , Herrmann M.J. , Kessouri F. , Estournel C. 
Published: August 2016

AbstractA 3‐D hydrodynamic‐biogeochemical coupled model has been used to estimate a budget of organic carbon and its interannual variability over the 5 year period 2004–2008 in the North‐Western Mediterranean Open Sea (NWMOS). The comparison of its results with in situ and satellite observations reveals that the timing and the magnitude of the convection and bloom processes during the study period, marked by contrasted atmospheric conditions, are reasonably well reproduced by the model. Model outputs show that the amount of nutrients annually injected into the surface layer is clearly linked to the intensity of the events of winter convection. During cold winters, primary production is reduced by intense mixing events but then spectacularly increases when the water column restratifies. In contrast, during mild winters, the primary production progressively and continuously increases, sustained by moderate new production followed by regenerated production. Overall, interannual variability in the annual primary production is low. The export in subsurface and at middepth is however affected by the intensity of the convection process, with annual values twice as high during cold winters than during mild winters. Finally, the estimation of a global budget of organic carbon reveals that the NWMOS acts as a sink for the shallower areas and as a source for the Algerian and Balearic subbasins.
Calcification of the planktonic foraminifera Globigerina bulloides and carbonate ion concentration: Results from the Santa Barbara Basin
Authors: Osborne Emily B. , Thunell Robert C. , Marshall Brittney J. , Holm Jessica A. , Tappa Eric J. , Benitez‐Nelson Claudia , Cai Wei‐Jun , Chen Baoshan 
Published: August 2016

AbstractPlanktonic foraminiferal calcification intensity, reflected by shell wall thickness, has been hypothesized to covary with the carbonate chemistry of seawater. Here we use both sediment trap and box core samples from the Santa Barbara Basin to evaluate the relationship between the calcification intensity of the planktonic foraminifera species Globigerina bulloides, measured by area density (µg/µm2), and the carbonate ion concentration of seawater ([CO32−]). We also evaluate the influence of both temperature and nutrient concentration ([PO43−]) on foraminiferal calcification and growth. The presence of two G. bulloides morphospecies with systematically different calcification properties and offset stable isotopic compositions was identified within sampling populations using distinguishing morphometric characteristics. The calcification temperature and by extension calcification depth of the more abundant “normal” G. bulloides morphospecies was determined using δ18O temperature estimates. Calcification depths vary seasonally with upwelling and were used to select the appropriate [CO32−], temperature, and [PO43−] depth measurements for comparison with area density. Seasonal upwelling in the study region also results in collinearity between independent variables complicating a straightforward statistical analysis. To address this issue, we use additional statistical diagnostics and a down core record to disentangle the respective roles of each parameter on G. bulloides calcification. Our results indicate that [CO32−] is the primary variable controlling calcification intensity while temperature influences shell size. We report a modern calibration for the normal G. bulloides morphospecies that can be used in down core studies of well‐preserved sediments to estimate past [CO32−].
Cracking energy density calculation of hyperelastic constitutive model and its application in rubber fatigue life estimations
Authors: Peng Yanhua , Liu Guixiong , Quan Yanming , Zeng Qilin 
Published: August 2016

ABSTRACTThe finite deformation of rubber under multiaxial stress will finally result in its fatigue failure. The ability to predict the effects of complex strain histories on fatigue life is a critical need. The cracking energy density (CED) distribution characteristics in the finite deformation and rubber fatigue life estimated by the CED criterion are investigated. Then the influences of the crack orientation angle θ and the principal stretch ratio λ on the relationship between CED and strain energy density (SED) are obtained. Finally, the results are used for predicting the fatigue life of rubber material and are compared to experimental values. The results indicate that the ratios of the predicted lives based on the CED damage parameter and measured lives are within two times scatter factor and that of the predicted lives based on the SED damage parameter and measured lives are greatly influenced by the crack orientation angle θ. The rubber fatigue life has great relationship with the angle of the crack plane normal vector and the first principal stretch direction. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44195.
Application of the dry‐spinning method to produce poly(ε‐caprolactone) fibers containing bovine serum albumin laden gelatin nanoparticles
Authors: Azimi Bahareh , Nourpanah Parviz , Rabiee Mohammad , Arbab Shahram , Grazia Cascone Maria , Baldassare Andrea , Lazzeri Luigi 
Published: August 2016

ABSTRACTWe designed and manufactured a polymeric system with combined hydrophilic–hydrophobic properties by loading gelatin nanoparticles (GNPs) containing bovine serum albumin (BSA) into poly(ε‐caprolactone) (PCL) fibers. Our ultimate goal was to create a device capable of carrying and releasing protein drugs. Such a system could find several biomedical applications, such as those in controlled release systems, surgical sutures, and bioactive scaffolds for tissue engineering. A two‐step desolvation method was used to produce GNPs, whereas PCL fibers were produced by a dry‐spinning method. The morphological, mechanical, and thermal properties of the produced system were investigated, and the distribution of nanoparticles both inside and on the surface of the fibers was examined. The effect of the particles on the biodegradability of the fibers was also evaluated. In vitro preliminary tests were performed to study the release of BSA from nanoparticle‐laden fibers and to compare this with its release from free nanoparticles. Our results indicate that the distribution of particles inside the fibers was quite homogeneous and only a few of them were present on the surface. The presence of the particles in the fibers did not affect the thermal properties of the PCL polymer matrix, although it created voids that affected the degradation characteristics so the PCL fibers favored faster erosion compared to the plain fibers. Preliminary results indicate that the release from GNP‐laden fibers occurred much more slowly compared to that in the free GNPs. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44233.
Ontogeny and Microanatomy of the Nasal Turbinals in Lemuriformes
Authors: Smith Timothy D. , Martell Molly C. , Rossie James B. , Bonar Christopher J. , Deleon Valerie B. 
Published: August 2016

ABSTRACTThe nasal cavity of strepsirrhine primates (lemurs and lorises) has the most primitive arrangement of extant primates. In nocturnal species, the numerous turbinals of the ethmoid bear a large surface area of olfactory mucosa (OM). In this study, we examine turbinal development in four genera of diurnal or cathemeral lemuriformes. In addition, we examined an age series of each genus to detect whether structures bearing OM as opposed to respiratory mucosa (RM) develop differently, as has been observed in nocturnal strepsirrhines. In adults, the maxilloturbinal is covered by highly vascular respiratory mucosa throughout its entire length, with large sinusoidal vessels in the lamina propria; any parts of other turbinals that closely borders the maxilloturbinal has a similar mucosa. Posteriorly, the most vascular RM is restricted in the nasopharyngeal duct, which becomes partitioned from the dorsal olfactory region. A comparison of newborns to adults reveals that the first ethmoturbinal increases more in length in the parts that are covered with RM than OM, which supports the idea that ethmoturbinals can specialize in more than one function. Finally, we observe that the regions of turbinals that are ultimately covered with RM develop more accessory lamellae or additional surface area of existing scrolls compared to the regions covered with OM. Because such outgrowths of bone develop postnatally and without cartilaginous precursors, we hypothesize that the complexity of olfactory lamellae within the ethmoturbinal complex is primarily established at birth, while respiratory lamellae become elaborated due to the epigenetic influence of respiratory physiology. Anat Rec, 299:1492–1510, 2016. © 2016 Wiley Periodicals, Inc.
Enhancing student retention of prerequisite knowledge through pre‐class activities and in‐class reinforcement
Authors: Taylor Ann T.S. , Olofson Eric L. , Novak Walter R.P. 
Published: August 2016

AbstractTo foster the connection between biochemistry and the supporting prerequisite concepts, a collection of activities that explicitly link general and organic chemistry concepts to biochemistry ideas was written and either assigned as pre‐class work or as recitation activities. We assessed student learning gains after using these activities alone, or in combination with regularly‐integrated clicker and discussion questions. Learning gains were determined from student performance on pre‐ and post‐tests covering key prerequisite concepts, biochemistry course exams, and student self‐evaluation. Long‐term retention of the material was assessed using a comprehensive exam given to a subset of the students. Our results show that using the pre‐class exercises in combination with integrative questions was effective at improving student performance in both the short and long term. Similar results were obtained at both a large research institution with large class enrollments and at a private liberal arts college with moderate enrollments. © 2016 by The International Union of Biochemistry and Molecular Biology, 45(2):97–104, 2017.
New Cytotoxic Bibenzyl and Other Constituents from Bauhinia ungulata L. (Fabaceae)
Authors: de Sousa Leôncio M. , de Carvalho Jarbas L. , da Silva Horlando C. , Lemos Telma L. G. , Arriaga Angela M. C. , Braz‐Filho Raimundo , Militão Gardênia C. G. , Silva Thiago D. S. , Ribeiro Paulo R. V. , Santiago Gilvandete M. P. 
Published: August 2016

A new bibenzyl, 2′‐hydroxy‐3,5‐dimethoxy‐4‐methylbibenzyl (1) and four known compounds identified as 2′‐hydroxy‐3,5‐dimethoxybibenzyl (2), liquiritigenin (3), guibourtinidol (4) and fisetinidol (5) were isolated from the roots of Bauhinia ungulata L. Phytochemical investigations of the stems of B. ungulata led to the isolation of the known compounds identified as liquiritigenin (3), guibourtinidol (4), fisetinidol (5), taraxerol (6), betulinic acid (7), taraxerone (8), glutinol (9), a mixture of sitosterol (10) and stigmasterol (11), pacharin (12), naringenin (13) and eriodictyol (14). The structures of these compounds were elucidated on the basis of their spectral data (IR, MS, 1D‐ and 2D‐NMR). The cytotoxicity of the bibenzyl 1 has been evaluated against four human cancer cell lines, showing the IC50 values of 4.3 and 6.5 μg ml−1 against pro‐myelocytic leukemia (HL‐60) and cervical adenocarcinoma (HEP‐2) cell lines, respectively. This article also registers for the first time the 13C‐NMR data of the known bibenzyl 2.
The influence of side branch stenosis on fractional flow reserve assessment of the main branch in a swine model
Authors: Oh Jun‐Hyok , Song Seunghwan , Kim Changhoon , Kim Jeongsu , Sup Park Jin , Won Lee Hye , Hyun Choi Jung , Cheol Lee Han , Soo Cha Kwang , Jong Hong Taek 
Published: August 2016

ObjectivesThe aim of this study was to explore the effect of one stenosis in a daughter artery on the fractional flow reserve (FFR) of another stenosis parallels in side branch. Background: The impact of one stenosis on the FFR of another parallel stenosis has not been evaluated. Methods: The proximal segments of the left anterior descending (LAD) and left circumflex (LCX) arteries were exposed and encircled with a Teflon pledget complex in seven swine (55–70 kg). Five degrees of stenosis (to approximate angiographic diameter stenoses of 0%, 25%, 50%, 75%, and 100%) were made by tightening the pledgets. FFR was evaluated simultaneously in the LAD and the LCX with two pressure wires in each coronary artery. A mixed‐effects linear model was used to evaluate the association between the FFR values. Results: A total of 115 paired FFR values were obtained. The FFR of the LAD and LCX were not significantly associated with each other (F = 0.237 and P = 0.627 for the LCX FFR to predict the LAD FFR; F = 0.541 and P = 0.463 for the LAD FFR to predict the LCX FFR). Conclusions: The individual FFR values of each parallel stenosis in the LAD and the LCX were not significantly influenced by each other. This relationship was independent of the mean aortic pressure and heart rate. © 2016 Wiley Periodicals, Inc.
Type 4a myocardial infarction: Incidence, risk factors, and long‐term outcomes
Authors: Yang Xiaoyu , Tamez Hector , Lai Carol , Ho Kalon , Cutlip Donald 
Published: August 2016

ObjectivesTo assess the incidence of and outcomes related to periprocedural (Type 4a) myocardial infarction (MI) in a cohort of patients undergoing percutaneous coronary intervention (PCI) for stable coronary disease or non ST‐elevation acute coronary syndrome with stable or falling cardiac troponin levels.BackgroundThe 2012 Third Universal Definition for Type 4a MI has not been prospectively studied in routine clinical practice.MethodsThe study included 516 patients undergoing eligible PCI at a single institution. Data were extracted from the National Cardiovascular Data Registry, review of electronic medical records, and telephone interviews. Clinical outcomes assessed at one year included all‐cause mortality, recurrent MI, or any repeat coronary revascularization.ResultsBased on the Third Universal Definition of MI, 53 (10.3%) patients met criteria for Type 4a MI and 116 (22.5%) had myocardial injury. The Type 4a MI and myocardial injury groups each had significantly higher numbers of stents, longer stent lengths, and more use of rotational atherectomy than the control group. Type 4a MI was not associated with one‐year mortality. The composite endpoint of death or recurrent MI at one year was similar between the Type 4a MI and myocardial injury groups (12 vs. 11%; P > 0.05), which were both higher compared with the control group (3%; P = 0.02, 0.03).ConclusionsType 4a MI and myocardial injury were frequent, and were associated with more complicated index PCI and more frequent death or recurrent MI at one year as compared with the control group. © 2016 Wiley Periodicals, Inc.
Multiple endocrine neoplasia phenocopy revealed as a co‐occurring neuroendocrine tumor and familial hypocalciuric hypercalcemia type 3
Authors: Hovden Silje , Jespersen Marie Louise , Nissen Peter H. , Poulsen Per Løgstrup , Rolighed Lars , Ladefoged Søren A. , Rejnmark Lars 
Published: August 2016

Key Clinical MessageFamilial hypocalciuric hypercalcemia type 3 should be considered as differential diagnosis in patients with suspected primary hyperparathyroidism and/or suspected multiple neoplasia syndrome, as correct diagnosis will spare the patients for going through multiple futile parathyroidectomies and for the worry of being diagnosed with a cancer susceptibility syndrome.
Effects of p‐ and n‐type Doping in Inorganic Fullerene MoS2 on the Hydrogen Evolution Reaction
Authors: Chhetri Manjeet , Gupta Uttam , Yadgarov Lena , Rosentsveig Rita , Tenne Reshef , Rao C. N. R. 
Published: August 2016

AbstractIn this report, a systematic study of the effects of p‐ and n‐type doping of the inorganic fullerene (IF) MoS2 on the efficiency of the hydrogen evolution reaction (HER) is described. Active edge site enriched IF‐MoS2, promoted by strategically introducing Nb (p‐type) and Re (n‐type) dopants (below 500 ppm), enables facile HER over a range of pH values. Experimental results suggest that although Nb‐doping on IF‐MoS2 leads to better electrocatalytic HER activity in an alkaline medium with an onset potential difference of 80 mV, Re‐doping gives excellent activity in an acidic medium. The present work presents a systematic study of HER activity by finely tuning the activity in different electrolyte media with varied pH values through deliberate doping of the parent catalyst with p‐ and n‐ type materials. The doped IF‐MoS2 catalysts exhibit excellent catalytic activity even with sea water as an electrolyte.
Mixed Anhydride Intermediates in the Reaction of 5(4H)‐Oxazolones with Phosphate Esters and Nucleotides
Authors: Liu Ziwei , Rigger Lukas , Rossi Jean‐Christophe , Sutherland John D. , Pascal Robert 
Published: August 2016

Abstract5(4H)‐Oxazolones can be formed through the activation of acylated α‐amino acids or of peptide C termini. They constitute potentially activated intermediates in the abiotic chemistry of peptides that preceded the origin of life or early stages of biology and are capable of yielding mixed carboxylic‐phosphoric anhydrides upon reaction with phosphate esters and nucleotides. Here, we present the results of a study aimed at investigating the chemistry that can be built through this interaction. As a matter of fact, the formation of mixed anhydrides with mononucleotides and nucleic acid models is shown to take place at positions involving a mono‐substituted phosphate group at the 3’‐ or 5’‐terminus but not at the internal phosphodiester linkages. In addition to the formation of mixed anhydrides, the subsequent intramolecular acyl or phosphoryl transfers taking place at the 3’‐terminus are considered to be particularly relevant to the common prebiotic chemistry of α‐amino acids and nucleotides.
ChemInform Abstract: First Principles and Experimental Studies of the Structural and Magnetic Ground State of the Ternary Compound MnFe3N.
Authors: Gil Rebaza A. V. , Navarro A. M. Mudarra , Martinez J. , Peltzer y Blanca E. L. 
Published: August 2016

AbstractAb initio DFT calculations, XRD, Moessbauer spectroscopy, and magnetization measurements reveal a ferrimagnetic ground state of MnFe3N in the space group P4/mmm.
ChemInform Abstract: Green One‐Pot Solvent‐Free Synthesis of Pyrazolo[1,5‐a]pyrimidines, Azolo[3,4‐d]pyridiazines, and Thieno[2,3‐b]pyridines Containing Triazole Moiety.
Authors: Abdelhamid Abdou O. , El‐Idreesy Tamer T. , Abdelriheem Nadia A. , Dawoud Huda R. M. 
Published: August 2016

AbstractSome of the title compounds exhibit competitive antibacterial and antifungal activity.
ChemInform Abstract: Nickel‐Catalyzed Difluoroalkylation of (Hetero)Arylborons with Unactivated 1‐Bromo‐1,1‐difluoroalkanes.
Authors: Xiao Yu‐Lan , Min Qiao‐Qiao , Xu Chang , Wang Ruo‐Wen , Zhang Xingang 
Published: August 2016

AbstractIn the Ni‐catalyzed cross‐coupling between (hetero)arylborons and unactivated bromodifluoroalkanes the combination of a bidentate bipyridine‐based ligand, and a monodentate pyridine‐based ligand provides an efficient catalytic system to prepare difluoroalkylated arenes.
ChemInform Abstract: Construction of Spirocarbocycles via Gold‐Catalyzed Intramolecular Dearomatization of Naphthols.
Authors: Wu Wen‐Ting , Xu Ren‐Qi , Zhang Liming , You Shu‐Li 
Published: August 2016

AbstractAn efficient preparation of spirocarbocycles by gold‐catalyzed 5‐endo‐dig cyclization of homopropargylic naphthols is presented.
ChemInform Abstract: Nickel‐Catalyzed Dimerization and Alkylarylation of 1,3‐Dienes with Alkyl Fluorides and Aryl Grignard Reagents.
Authors: Iwasaki Takanori , Min Xin , Fukuoka Asuka , Kuniyasu Hitoshi , Kambe Nobuaki 
Published: August 2016

AbstractNi‐catalyzed dimerization of butadiene and subsequent alkylarylation reaction with arylmagnesium bromide and primary alkyl fluorides constitutes an efficient synthesis of 3‐alkyl‐8‐aryl‐1,6‐octadienes.
ChemInform Abstract: Recyclable Magnetic Nanoparticle‐Supported Iodoarene Catalysts for Oxidation of 4‐Alkoxyphenols to Quinones.
Authors: Nambu Hisanori , Shimokawa Ikumi , Fujiwara Tomoya , Yakura Takayuki 
Published: August 2016

AbstractFEP and FES are suitable catalysts for the oxidation of 4‐alkoxyphenols towards benzoquinones in the presence of Oxone as a co‐oxidant.
ChemInform Abstract: Product‐Derived Bimetallic Palladium Complex Catalyzes Direct Carbonylation of Sulfonylazides.
Authors: Zhao Jin , Li Zongyang , Song Shaole , Wang Ming‐An , Fu Bin , Zhang Zhenhua 
Published: August 2016

AbstractA novel Pd‐catalyzed nitrene‐transfer reaction of sulfonylazides with CO is developed which provides a new approach to sulfonylurea derivatives.
ChemInform Abstract: A D‐Camphor‐Based Schiff Base as a Highly Efficient N,P Ligand for Enantioselective Palladium‐Catalyzed Allylic Substitutions.
Authors: Liu Qiao‐Ling , Chen Weifeng , Jiang Qun‐Ying , Bai Xing‐Feng , Li Zhifang , Xu Zheng , Xu Li‐Wen 
Published: August 2016

AbstractNew Schiff bases are effective chiral phosphine ligands for the asymmetric palladium‐catalyzed allylic alkylation of activated methylene compounds, the allylic etherification of alcohols, and the allylic amination with primary or secondary amines.
ChemInform Abstract: Enzyme‐ and Ruthenium‐Catalyzed Enantioselective Transformation of α‐Allenic Alcohols into 2,3‐Dihydrofurans.
Authors: Yang Bin , Zhu Can , Qiu Youai , Baeckvall Jan‐E. 
Published: August 2016

AbstractAllenic alcohols (I) can be readily cyclized to 2‐substituted 2,3‐dihydrofurans using Shvo′s ruthenium catalyst.
ChemInform Abstract: Microwave‐Assisted Copper‐Catalyzed Oxidative Cyclization of Acrylamides with Non‐Activated Ketones.
Authors: Zhao Yaping , Sharma Nandini , Sharma Upendra K. , Li Zhenghua , Song Gonghua , Van der Eycken Erik V. 
Published: August 2016

AbstractAn operationally simple, environmental friendly, and efficient microwave‐assisted protocol for the oxidative cyclization of acrylamide derivatives with non‐activated ketones to generate 3,3‐disubstituted oxindoles is described.
ChemInform Abstract: Piperidine‐Catalyzed 1,3‐Dipolar Cycloaddition of Diazoesters to Enones
Authors: Huang Jiayao , Wu Minghu , Hu Liqiang , Guo Haibin , Sun Shaofa 
Published: August 2016

Abstractgives pyrazoles in high yields with excellent regioselectivity
ChemInform Abstract: Asymmetric Palladium‐Catalyzed Alkene Carboamination Reactions for the Synthesis of Cyclic Sulfamides.
Authors: Garlets Zachary J. , Parenti Kaia R. , Wolfe John P. 
Published: August 2016

AbstractThe synthesis of cyclic sulfamides by enantioselective Pd‐catalyzed alkene carboamination reactions between N‐allylsulfamides and aryl or alkenyl bromides is described.
ChemInform Abstract: Dirhodium(II)‐Catalyzed Annulation of Enoldiazoacetamides with α‐Diazoketones: An Efficient and Highly Selective Approach to Fused and Bridged Ring Systems.
Authors: Cheng Qing‐Qing , Yedoyan Julietta , Arman Hadi , Doyle Michael P. 
Published: August 2016

AbstractThe addition of a mixture of two structurally different diazocarbonyl compounds to a dirhodium catalyst produces the donor‐acceptor cyclopropane‐fused benzoxa[3.2.1]octane scaffolds (III) with excellent chemo‐, regio‐ and diastereoselectivity.
ChemInform Abstract: Iodine‐Catalyzed Oxidative Benzylic C—H Bond Amination of Azaarenes: Practical Synthesis of Quinazolin‐4(3H)‐ones.
Authors: Yang Luo , Shi Xin , Hu Ben‐Quan , Wang Li‐Xia 
Published: August 2016

AbstractAn efficient oxidative amination of the benzylic C—H bond of aza arenes with 2‐aminobenzamides affords 2‐heteroarylquinazolinones.