bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of Travel Agencies' Environment, Social, and Governance Marketing Activities on Consumer Behavioral Intentions
Authors: Yun Jeewoo , Klaus Phil , Hong Eunpyo , Lee Sangwoo , Park Jungkun 
Published: October 2024

ABSTRACTEnvironment, social, and governance (ESG) marketing activities are becoming increasingly crucial for business growth. This study surveys 322 participants in the US to determine the effects of consumer beliefs and attitudes toward travel agencies' ESG activities on consumer behavioral intentions. The moderating effects of tourism innovativeness and tourists' enjoyment are explored. The results reveal that environmental beliefs have a positive influence on attitudes toward ESG. Conversely, social and governance beliefs exhibit a positive impact solely on attitudes toward ESG advertisements, within the context of attitudes toward ESG in general. A positive attitude toward ESG advertising and branding activities influences the intention to repurchase. This study confirms that a positive attitude toward ESG branding activities has a positive effect on word of mouth. Tourist innovativeness plays a moderating role in the relationship between attitudes toward ESG advertising and word of mouth (WOM).
Consumer forgiveness: A literature review and research agenda
Authors: Yoruk Irem , Hsu Jen‐Hsien , Lee Zach W. Y. 
Published: October 2024

AbstractConsumer forgiveness represents a compelling phenomenon for marketers, as understanding and leveraging forgiveness allows repairing consumer brand relationships. Marketing scholars began to pay closer attention to consumer forgiveness in the last decade with attempts to better understand and analyze this construct. This literature review on consumer forgiveness seeks to enrich the discourse on this phenomenon through a comprehensive systematic review of 89 articles. Through this literature review, we synthesize the findings of 89 articles to (1) understand how involved agents (e.g., firms/brands, humans, and autonomous technologies) influence the consumer forgiveness process, (2) develop a theoretical integrative framework delineating salient psychological mechanisms of the consumer forgiveness process, and (3) propose a future research agenda on consumer forgiveness.
Structure‐based design of antibodies targeting the EBNA1 DNA‐binding domain to block Epstein–Barr virus latent infection and tumor growth
Authors: Han Yongyue , Wu Fang , Zhang Ying , Liu Jun , Wu Yuzhe , Wang Yuecheng , Jiang Xiwen , Chen Xin , Xu Wei 
Published: October 2024

AbstractThe Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1) is critically involved in maintaining episomes during latent infection and promoting tumorigenesis. The development of an epitope‐specific monoclonal antibody (mAb) for EBNA1 holds great promise due to its high affinity and specificity, offering a new and innovative approach for the treatment of EBV‐related diseases. In this proof‐of‐concept study, we employed a structure‐based design strategy to create three unique immunogens specifically targeting the DNA binding state of the EBNA1 DBD. By immunizing mice, we successfully generated a mAb, named 5E2‐12, which selectively targets the DNA binding interface of EBNA1. The 5E2‐12 mAb effectively disrupts the interaction between EBNA1 and DNA binding, resulting in reduced proliferation of EBV‐positive cells and inhibition of xenograft tumor growth in both cellular assays and mouse tumor models. These findings open up new avenues for the development of innovative biological macromolecular drugs that specifically target EBNA1 and provide potential for clinical therapy options for early‐stage EBV‐positive tumors. The epitope‐specific mAb approach demonstrates novelty and innovation in tackling EBV‐related diseases and may have broad implications for precision medicine strategies in the field of viral‐associated cancers.
On the possibility of long‐distance transmission of OAM beam in rectangular tunnels
Authors: Ouyang Qixiang , Feng Ju , Du Wei , Shang Yuping , Liao Cheng 
Published: October 2024

AbstractThis letter explores the possibility of long‐distance transmission of an orbital angular momentum (OAM) beam through rectangular tunnels. Theoretical analysis reveals that the OAM beam propagating in the tunnel with square cross section fulfills the conditions for axial propagation and exhibits azimuth symmetry. In comparison with free‐space OAM generation, we draw the conclusion that long‐distance transmission of OAM beams is achievable in the tunnels with square cross section. The validity of our conclusion is further substantiated through numerical experiments. Simulation results demonstrate that the first‐order OAM beam radiated by a uniform circular antenna array exhibits favorable helical phase distribution and the circular symmetry of the amplitude distribution in the tunnel beyond the Rayleigh distance. However, these characteristics degrade with increasing mode order and propagation distance, because the increase of high‐order OAM beam divergence angle and propagation distance will exacerbate the impact of multipath effects in the tunnel environment.
Spermatogenic Stem Cells: Core Biology, Defining Features, and Utilities
Authors: Lord Tessa , Oatley Jon M. 
Published: October 2024

ABSTRACTThe actions of spermatogenic stem cells (SSCs) provide the foundation for continual spermatogenesis and regeneration of the cognate lineage following cytotoxic insult or transplantation. Several decades of research with rodent models have yielded knowledge about the core biology, morphological features, and molecular profiles of mammalian SSCs. Translation of these discoveries to utilities for human fertility preservation, improving animal agriculture, and wildlife conservation are actively being pursued. Here, we provide overviews of these aspects covering both historical and current states of understanding.
Valves for the Voiceless: Time to Speaking Valve Use in Posttracheostomy Patients After Multidisciplinary Initiative
Authors: Huang Victoria W. , DeVore Elliana K. , Kaul Sumedh , Parikh Mihir , Hayes Margaret M. , Teng Stephanie E. 
Published: October 2024

AbstractObjectiveTo review speaking valve (SV) use at a tertiary academic medical center and determine whether a multidisciplinary team implementation of SV protocols increased SV use and decreased time to SV trials.MethodsRetrospective case series of patients who underwent a tracheostomy between 2017 and 2023 before and after the dissemination of new protocols from a new multidisciplinary tracheostomy care initiative in 2019. The calendar days between meeting SV eligibility criteria and initial trial of SV were compared. Eligibility criteria for SV was defined as any patient ≥48 hours posttracheotomy who can breathe unassisted, off mechanical ventilation, tolerate a deflated cuff, and participate in an evaluation. Interrupted time series analysis using segmented negative binomial regression assessed the change in time to SV placement before and after protocol implementation.ResultsA total of 421 patients were identified. After new protocols were disseminated, eligible patients with a SV trial increased from 75% to 95% with an increase in percentage of patients who tolerated the SV on their first attempt from 60% to 75%. Interrupted time series analysis demonstrated protocol implementation was associated with an overall 80% decrease in time to SV placement.DiscussionContinued barriers to SV implementation such as elevated tracheal pressures due to large tracheostomy sizes, or inappropriately early consultations with patients unable to participate in SV exam, may be amenable to further institution‐level quality improvement initiatives.Implications for PracticeA multidisciplinary initiative's dissemination of protocols with algorithms for SLP consultation and SV use can help standardize post‐operative tracheostomy care.
Exploring factors leading to job disengagement among arts therapists employed in Israel's education system
Authors: Snir Sharon , Regev Dafna , Hachohen Shir Korman , Roginsky Efrat 
Published: October 2024

AbstractArts therapy is provided in most educational settings in Israel, but post‐Covid, many arts therapists working in schools resigned or took leave, and other therapists have displayed little interest in taking their place. This study explored the experiences of therapists who left the system, with the purpose of making their voices heard and promoting policy development pertaining to the employment of arts therapists in the education system. We conducted semi‐structured in‐depth interviews with 15 arts therapists who left their jobs in the school system, asking them about their initial expectations upon entering the educational system, their experiences and reactions to their work environment, and the issues prompting them to seek job opportunities elsewhere. The findings suggest that along with the need for arts therapists to be proactive and search for solutions, the Ministry of Education and Regional Support Centers need to promote flexibility in the systemic hierarchy, improve communication, and provide more supervisory evaluation and support of the system, especially during times of change and crisis. From a policy perspective, we advocate for a unique definition of arts therapists' working conditions and the provision of opportunities for career growth.
Research Progress in the Synthesis of CL‐20 and the Application of Catalysts in the Synthesis
Authors: Wang Hui , Cheng Yitong , Macheka Henrie George , An Huiyong , Xie Yuan 
Published: October 2024

AbstractAs the highest energy and most powerful elemental energetic compound known so far, CL‐20 has attracted much attention since its advent. With its use not solely being the production of explosives, but also has great application prospects in other fields, such as propellants and smoke agents. In this paper, the synthetic process of CL‐20 is reviewed. It is divided into two parts: the traditional synthetic method and the new synthetic method. Especially due to the improvement of traditional synthetic method. In recent years, most studies on CL‐20 focus on how to use catalysts to optimize the two processes of hydrodebenzylation of HBIW and the nitration synthesis of CL‐20 with different nitration precursors. Therefore, this review focuses on the utilization of catalysts in the synthetic process, and predicts a bright future research direction focused on CL‐20.
Neoadjuvant immunochemotherapy followed by ex situ lung auto‐transplant (Oto procedure) for central lung cancer: A case report with literature review
Authors: Su Po‐Keng , Lin Chen‐Chieh , Hu Szu‐Yen , Lin Ming‐Hsien , Wu Chun‐Yu , Yang Shun‐Mao , Oto Takahiro 
Published: October 2024

AbstractSleeve and double‐sleeve lobectomies are lung‐sparing techniques for treating central lung cancers. However, if the tumour extends to involve the bronchi and vessels, lung auto‐transplantation may be an alternative to pneumonectomy. Neoadjuvant therapy after surgery is the most common strategy for patients with extensive central lung cancer. Herein, we report a case of central lung cancer in a patient who underwent immunochemotherapy as neoadjuvant therapy following lung auto‐transplantation. A 68‐year‐old man with stage IIIA non‐small cell lung cancer and left upper lobe squamous cell carcinoma underwent neoadjuvant immunochemotherapy. Following partial regression, a multidisciplinary team decided on a back‐table procedure with auto‐lung transplantation after pneumonectomy to preserve pulmonary function. The patient had an uneventful recovery and was discharged after three weeks with no residual tumour or lymph node metastases. Lung auto‐transplantation can be successfully performed in non‐lung transplantation centres, potentially broadening treatment options for patients with central lung cancer.
Nitrogen source regulates soil nitrification and nitrogen losses more than nitrification inhibitor and herbicide: A laboratory evaluation
Authors: Neels William , Jhala Amit , Jin Virginia , Patel Swetabh , Maharjan Bijesh , Iqbal Javed 
Published: October 2024

AbstractIncreased environmental nitrogen (N) losses have prompted the use of enhanced efficiency nitrogen fertilizers, including nitrification inhibitors. However, the comparative effects of nitrification inhibitors with conventional nitrogen fertilizers and herbicides on soil nitrification and nitrogen losses remain poorly understood. This study evaluated the impact of a nitrification inhibitor (Instinct NXTGEN), two nitrogen sources (broadcast urea vs. injected aqueous ammonia), and a preemergence herbicide (Acuron) on (1) soil nitrification through a 25‐day soil incubation experiment and (2) NH3 volatilization, NO3‐N leaching, and N2O‐N emissions through a 31‐day soil column study in loamy sand soil. In both experiments, treatments included combinations of nitrification inhibitor versus no inhibitor, two nitrogen sources, and preemergence herbicide versus no herbicide. Results revealed that nitrogen source significantly influenced nitrification, with injected aqueous ammonia reducing nitrification by 33% compared to surface broadcast urea. Nitrification inhibitors and herbicide had no effect on soil nitrification. Injected aqueous ammonia reduced NH3 volatilization by 87% compared to surface broadcast urea, but the effect of the nitrification inhibitor on NH3 volatilization was inconsistent across both nitrogen sources. Injected aqueous ammonia led to 39% higher cumulative nitrogen (NO3‐N + NH4‐N) leaching than urea, while the nitrification inhibitor had an inconsistent effect on NO3‐N leaching across both nitrogen sources. No significant differences in N2O‐N emissions were observed among treatments, and the herbicide had no effect on any measured parameters. These findings suggest that nitrogen source plays a more critical role in regulating soil nitrogen losses than nitrification inhibitors or herbicides.
Synthesis of Ternary Layered Double Hydroxides and Application for Wastewater Treatment
Authors: Bar Amit , Sarkar Sudarshan , Kumar Sanjeev , Singh R.S. , Upadhyay Chandan 
Published: October 2024

AbstractThis study systematically investigates the optimization of synthesis parameters for ternary layered double hydroxide (LDH) to achieve a pure phase and high crystallinity. The , LDH is synthesized using the coprecipitation method and applied for wastewater treatment. The ternary LDH is synthesized at 60 °C for 24 h and exhibited maximum crystallinity with a crystallite size of 4 nm. The crystallinity index (CI) is a quantitative indicator of crystallinity, which is calculated using the X‐ray diffraction (XRD) method. The influence of reaction time on the structural characteristics of this LDH was thoroughly investigated, mainly focusing on achieving well‐crystalline LDH. Experimental results revealed a direct correlation between reaction time and crystallinity. This study highlights the significant influence of controlled synthesis and reaction time on producing high crystalline ternary LDH. The role of different parameters, such as solution pH, adsorbent dosage, contact time, and dye concentration, has been investigated. The adsorption isotherm data is analyzed using different isotherm models, which shows this material having a significant adsorption capacity of 82.92 mg/g for Congo Red dye.
Theoretical Investigation of Para‐Substituted Aniline Based Dendritic Architecture: In‐Silico ADMET, DFT, and Machine Learning Approach
Authors: Hemso B Elizabeth , Neikha Kevizali , Das Parineeta , Gupta Anshika , Puzari Amrit 
Published: October 2024

AbstractDendrimers are polymeric compounds which exhibit notable advantages, particularly in medicinal chemistry. The therapeutic potential of these molecular architectures can be screened through in silico method which facilitates the identification of the ones with the highest potential for further investigation. Here, we have reported the in silico investigation of a series of dendritic architecture based on para‐substituted aniline. Density functional theory (DFT) method was employed to optimize the structures and to analyze the quantum chemical parameters. The absorption, distribution, metabolism, excretion, and toxicity (ADMET) profiling was additionally assessed, which unveiled favorable drug‐like characteristics and moderate to good bioactivity across all compounds. Utilizing the drug‐likeness property in machine learning techniques, the potential for predicting novel drug‐like dendrimers was explored.
Exploring Benzo[b][1,4]Thiazine Derivatives: Multitarget Inhibition, Structure–Activity Relationship, Molecular Docking, and ADMET Analysis
Authors: Alishba  , Ali Irfan , Hameed Shehryar , Khan Khalid Mohammed , Salar Uzma , Taha Muhammad , Sadeghian Nastaran , Taslimi Parham , Tuzun Burak , Özerkan Dilşad , Dedeakayogullari Huri , Ulukaya Engin 
Published: October 2024

AbstractA series of benzothiazine derivatives (1–17) were synthesized via an intermolecular cyclocondensation reaction involving 2‐aminothiophenol (i) and substituted phenacyl bromide (ii). Structural elucidation of these synthetic derivatives utilized EI–MS, HR‐EIMS, 1H NMR, and 13C NMR spectroscopic techniques. The synthesized analogs were evaluated against key enzyme targets (acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α‐glucosidase (α‐Glu)) and tested for cytotoxicity against various cancer cell lines. Six compounds were selected based on their inhibition profiles, exhibiting significant inhibitory potential against enzymes. In silico studies corroborated the observed inhibitory activities, aligning closely with experimental outcomes. Additionally, an ADME/T study provided insights into pharmacokinetic and safety profiles, identifying promising candidates for future drug development efforts.
Zeolite Crystallization Inside Chemically Recyclable Ordered Nanoporous Co3O4 Scaffold: Precise Replication and Accelerated Crystallization
Authors: Takaoka Kohei , Matsuno Takamichi , Koike Masakazu , Muramoto Naho , Wada Hiroaki , Kuroda Kazuyuki , Shimojima Atsushi 
Published: October 2024

AbstractThe synthesis of mesoporous zeolites has garnered attention with regard to improving their catalytic and adsorption performances. While the hard‐templating method provides opportunities to design precisely controlled hierarchical micro‐ and mesoporous structures, synthesizing mesoporous zeolites without external precipitation requires significant work. This is mainly due to the absence of usable templates other than carbon with hydrophobic surfaces. Herein, it is demonstrated that the Co3O4 template is valuable in preparing mesoporous silicalite‐1 and ZSM‐5 with a precisely controlled porous structure through hydrothermal synthesis. Unlike conventional carbon templates, the Co3O4 template is relatively hydrophilic, effective in suppressing external precipitation, and is reusable by dissolving in an acidic solution. The crystallization process also differs from that of the carbon template, as the silicate precipitates on a 3D ordered nanoporous Co3O4 scaffold, followed by crystallization and crystal growth. Furthermore, it is unexpectedly observed that the zeolite crystallization is accelerated in the Co3O4 template. The synthetic approach utilizing nanoporous metal oxides opens new doors for the control of the hierarchical structure of zeolites, as well as for the design of metal oxide–zeolite nanocomposite catalysts, due to the potential extensibility of the combination of metal oxides and zeolites.
Thermodynamics and Kinetics‐Directed Regulation of Nucleic Acid‐Based Molecular Recognition
Authors: Liu Yihao , Zhao Zihan , Zeng Yuqi , He Minze , Lyu Yifan , Yuan Quan 
Published: October 2024

AbstractNucleic acid‐based molecular recognition plays crucial roles in various fields like biosensing and disease diagnostics. To achieve optimal detection and analysis, it is essential to regulate the response performance of nucleic acid probes or switches to match specific application requirements by regulating thermodynamics and kinetics properties. However, the impacts of thermodynamics and kinetics theories on recognition performance are sometimes obscure and the relative conclusions are not intuitive. To promote the thorough understanding and rational utilization of thermodynamics and kinetics theories, this review focuses on the landmarks and recent advances of nucleic acid thermodynamics and kinetics and summarizes the nucleic acid thermodynamics and kinetics‐based strategies for regulation of nucleic acid‐based molecular recognition. This work hopes such a review can provide reference and guidance for the development and optimization of nucleic acid probes and switches in the future, as well as for advancements in other nucleic acid‐related fields.
Pressure–impulse diagrams of RC beams considering fire–blast interaction
Authors: Colombo Matteo , Martinelli Paolo 
Published: October 2024

AbstractWhen analyzing military, defense, or structures/infrastructures deemed critical, explosion‐induced actions—often associated with malicious actions—play a significant role. The combined effect of a blast and fire is not uncommon: in fact, an explosion can be the extreme consequence of a fire or vice versa, a fire can occur as the result of an explosion. Although advanced numerical approaches can be a proper solution for analyzing critical structures and infrastructures subjected to accidental actions, their complexity makes these approaches unsuitable for the analysis of ordinary buildings or even for the preliminary design of structures. A pressure–impulse diagram is an easy and common tool that can be adopted to verify the safety of structural members for a wide range of blast scenarios even considering the damage caused by a previous fire. This study aims to compare different approaches that can be adopted for the construction of pressure–impulse diagrams of reinforced concrete structures subjected to a blast and a blast preceded by fire. Taking as a reference case a statically indeterminate beam with three supports, this work presents the influence of the methods of analysis on the safety level assessed through pressure–impulse diagrams.