bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facile fabrication and characterization of polyimide nanofiber reinforced photocured hybrid electrolyte for Li‐ion batteries
Authors: Aytan Emre , Uğur Mustafa Hulusi , Kayaman‐Apohan Nilhan 
Published: June 2017

In this study, a novel ion conductive polyimide (PI) nanofiber reinforced photocured hybrid electrolyte has been fabricated. Polyimide fibers were fabricated with the reaction between 4,4′‐oxydianiline (ODA) and 3,3′,4,4′‐benzophenonetetracarboxylic dianhydride (BTDA) followed by electrospinning and thermal imidization methods. Then, PI electrospun fibers were dipped into hybrid resin formulation containing bisphenol A ethoxylate dimethacrylate (BEMA), poly (ethylene glycol) methyl ether methacrylate (PEGMA) and 3‐(methacryloyloxy) propyltrimethoxysilane (MEMO) and then photocured to prepare PI nanofiber reinforced electrolyte membrane. Photocured membranes were soaked into lithium hexafluorophosphate (LiPF6) before measuring electrochemical stability and ionic conductivity of hybrid polyelectrolyte. The chemical structure and electrochemical performance of the electrolytes were examined by Fourier transform infrared (FTIR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), electrochemical impedance spectroscopy (EIS), linear sweep voltammetry (LSV) and scanning electron microscopy (SEM) analysis. The incorporation of MEMO into organic matrix effectively increased the modulus from 2.83 to 5.91 MPa. The obtained results showed that a suitable electrolyte for Li‐ion batteries with high lithium uptake ratio, high conductivity (7.2 × 10−3 S cm−1) at ambient temperature and wide stability window above 5.5 V had been prepared. Copyright © 2017 John Wiley & Sons, Ltd.
A rare castration‐resistant progenitor cell population is highly enriched in Pten‐null prostate tumours
Authors: Sackmann Sala Lucila , Boutillon Florence , Menara Giulia , De Goyon‐Pélard Andréa , Leprévost Mylène , Codzamanian Julie , Lister Natalie , Pencik Jan , Clark Ashlee , Cagnard Nicolas , Bole‐Feysot Christine , Moriggl Richard , Risbridger Gail P , Taylor Renea A , Kenner Lukas , Guidotti Jacques‐Emmanuel , Goffin Vincent 
Published: June 2017

AbstractCastration‐resistant prostate cancer is a lethal disease. The cell type(s) that survive androgen deprivation remain poorly described, despite global efforts to understand the various mechanisms of therapy resistance. We recently identified in wild‐type (WT) mouse prostates a rare population of luminal progenitor cells that we called LSCmed according to their FACS profile (Lin−/Sca‐1+/CD49fmed). Here, we investigated the prevalence and castration resistance of LSCmed in various mouse models of prostate tumourigenesis (Pb‐PRL, Ptenpc−/−, and Hi‐Myc mice). LSCmed prevalence is low (∼8%, similar to WT) in Hi‐Myc mice, where prostatic androgen receptor signalling is unaltered, but is significantly higher in the two other models, where androgen receptor signalling is decreased, rising up to more than 80% in Ptenpc−/− prostates. LSCmed tolerate androgen deprivation and persist or are enriched 2–3 weeks after castration. The tumour‐initiating properties of LSCmed from Ptenpc−/− mice were demonstrated by regeneration of tumours in vivo. Transcriptomic analysis revealed that LSCmed represent a unique cell entity as their gene expression profile is different from luminal and basal/stem cells, but shares markers of each. Their intrinsic androgen signalling is markedly decreased, explaining why LSCmed tolerate androgen deprivation. This also illuminates why Ptenpc−/− tumours are castration‐resistant since LSCmed represent the most prevalent cell type in this model. We validated CK4 as a specific marker for LSCmed on sorted cells and prostate tissues by immunostaining, allowing for the detection of LSCmed in various mouse prostate specimens. In castrated Ptenpc−/− prostates, there was significant proliferation of CK4+ cells, further demonstrating their key role in castration‐resistant prostate cancer progression. Taken together, this study identifies LSCmed as a probable source of prostate cancer relapse after androgen deprivation and as a new therapeutic target for the prevention of castrate‐resistant prostate cancer. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Fabrication, chemical modification, and topographical patterning of reactive gels assembled from azlactone‐functionalized polymers and a diamine
Authors: Wancura Megan M. , Anex‐Ries Quinn , Carroll Anna L. , Paola Garcia Ana , Hindocha Pooja , Buck Maren E. 
Published: June 2017

ABSTRACTThe work reported here demonstrates an approach to the fabrication of chemically reactive and topographically patterned hydrogels using the azlactone‐functionalized polymer poly(2‐vinyl‐4,4'‐dimethylazlactone) (PVDMA) and the hydrophilic diamine Jeffamine®. Gels were initially assembled in DMSO but can be subsequently transferred into aqueous media to form hydrogels. Spectroscopic characterization of assembled gels demonstrated that variation in the stoichiometric ratio of azlactones to amines during gel synthesis permits control over the extent of crosslinking in the gels. Residual azlactones not consumed during crosslinking can be exploited to further functionalize these gels with hydrophobic, hydrophilic, and macromolecular amines that influence the physicochemical properties of these materials in aqueous solvents. The surface and bulk of these gels can be differentially functionalized (i.e., different functional groups on the gel surface relative to the bulk) by taking advantage of different rates of diffusion of macromolecular amines versus small molecule amines into assembled gels. Finally, these azlactone‐functionalized gels can be topographically patterned with microwell arrays using a replica molding technique and chemically modified postfabrication with amine nucleophiles. This reactive approach to the fabrication of topographically patterned and chemically functionalized hydrogels offers a straightforward method for the rapid synthesis of micropatterned scaffolds of interest in a broad range of applications. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 3185–3194
Synthesis and chiroptical properties of helical polyallenylferrocenes
Authors: Chai Hao , Hu Jianfeng , Shi Qi , Zhang Hao 
Published: June 2017

ABSTRACTThe allylnickel‐catalyzed living coordination polymerization of allenylferrocene was compounded, two allenylferrocene derivatives (L‐1 and D‐1) bearing chiral amide pendants were designed and synthesized. The living coordination polymerization of L‐1 and D‐1 were afforded by the allynickel(II) complexes, which gave the polymer with controlled molecular weights and narrow molecular weight distribution in high yields. Three polyallenylferrocenes exhibited electrochemical properties. The helical structure was stable in the aprotic solvents observed through the circular dichroism spectra. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 2663–2669
Reaction mechanism of hydrogen cyanide catalyzed by gas‐phase titanium
Authors: Wang Xiaoli , Wang Yongcheng , Li Shuang , Zhang Yuwei 
Published: June 2017

AbstractTo explore the details of the reaction mechanism of Ti atom with HCN, the reactive site and reactivity have been predicted first, the potential energy surfaces have been systematically studied at different theoretical levels. Four different reaction pathways and product distribution are discussed by means of the activation strain model and Curtin–Hammett principle. In addition, the structures, bonding properties and the frontier molecular orbital interaction diagrams of main stationary points were analyzed by atoms in molecules and natural bond orbital. The results show that for this system, there are four reaction pathways, in which path b (HCN＋Ti→IM1→TS1→IM2→T2b→IM4) is the most favorable pathway.
How Will I Know What My Students Need? Preparing Preservice Teachers to Use Running Records to Make Instructional Decisions
Authors: Gillett Erin , Ellingson Susan Pierson 
Published: June 2017

AbstractEffective teachers use assessment data to make instructional decisions. One of the most informative techniques to assess young learners’ reading progress in the primary grades is the running record. Running records provide concrete evidence of students’ skills, reading levels, strategies, and progress as readers. The data gathered help teachers identify readers’ current strengths, needs, and reading levels. Frequent consideration of assessment data allows teachers to make up‐to‐the‐minute evidence‐based instructional decisions for their students. How do preservice teachers learn to take, score, and analyze running records to inform their literacy instruction? This article describes two approaches used by teacher educators to equip preservice elementary teachers with beginning proficiency in using running records to determine next steps of reading instruction for young students. The authors also provide novice teacher educators with insight into how they might incorporate running records instruction into their assessment or methods coursework, and they suggest resources to guide follow‐up instruction.
Relationship Between Expression of Proteins ERCC1, ERCC2, and XRCC1 and Clinical Outcomes in Patients with Rectal Cancer Treated with FOLFOX‐Based Preoperative Chemoradiotherapy
Authors: Huang Ming‐Yii , Huang Joh‐Jong , Huang Chun‐Ming , Lin Chih‐Hung , Tsai Hsiang‐Lin , Huang Ching‐Wen , Chai Chee‐Yin , Lin Chia‐Yang , Wang Jaw‐Yuan 
Published: June 2017

AbstractBackground
Platinum resistance enhances DNA damage repair through nucleotide excision repair mechanisms involving the excision repair cross‐complementing group 1 (ERCC1), X‐ray cross‐complementing group 1 (XRCC1), and excision repair cross‐complementing group 2 (ERCC2). We evaluated the correlation between the expression of these three DNA repair genes and clinical outcomes in patients with rectal cancer receiving FOLFOX‐based preoperative chemoradiotherapy (CRT).MethodsUsing immunohistochemistry, we examined the expression of ERCC1, ERCC2, and XRCC1 in pre‐CRT cancer tissues from 86 patients with rectal cancer who had undergone curative resection and preoperative CRT with FOLFOX‐4 to identify potential predictors of clinical outcomes.ResultsFollowing CRT, 57 and 29 patients were classified as responders (pathological tumor regression grade TRG 0 and TRG 1) and poor responders (TRG 2 and TRG 3), respectively. The multivariate analysis revealed that ERCC1 overexpression was correlated with a poor CRT response [p < 0.0001; odds ratio (OR), 9.397; 95% confidence interval (CI) 2.721–32.457]. Furthermore, a poor response to CRT (pathological TRG of 2–3) (p = 0.18; OR 5.685; 95% CI 1.349–23.954) and abnormal pre‐CRT serum carcinoembryonic antigen levels (>5 ng/mL) (p = 0.03; OR 6.288; 95% CI 1.198–33.006) were independent predictors of postoperative relapse. By contrast, ERCC2 and XRCC1 expression did not play predictive roles in the analyzed patients.Conclusions
ERCC1 overexpression is associated with a poor preoperative CRT response in patients with rectal cancer receiving FOLFOX‐based preoperative CRT. ERCC1 is a potential biomarker for identifying patients who can benefit from customized treatment programs.
Safety of Anticoagulation Interruption in Patients Undergoing Surgery or Invasive Procedures: A Systematic Review and Meta‐analyses of Randomized Controlled Trials and Non‐randomized Studies
Authors: Hovaguimian Frédérique , Köppel Sabrina , Spahn Donat R. 
Published: June 2017

AbstractBackgroundThe safety of anticoagulation interruption in patients requiring surgical or invasive procedures remains unclear. We thus performed a systematic review and meta‐analyses of randomized controlled trials (RCTs) and non‐randomized studies (NRS).MethodsMEDLINE, Embase and Central databases were searched to March 2017 without date or language restrictions. We considered RCTs and NRS comparing anticoagulation interruption with any anticoagulation (continuation or heparin bridging) in adult surgical patients taking oral anticoagulation. Data were independently extracted. The quality of the evidence was assessed following recommendations from the Cochrane collaboration (GRADE approach). Risk ratios were calculated for 30‐day events: thromboembolic (TE) events, major bleeding and mortality. Additional analyses explored the effects of different anticoagulation strategies.ResultsTwelve reports were included: 4 RCTs (2190 participants) and 8 NRS (18993 participants). Trials included mostly participants with atrial fibrillation. Interrupting anticoagulation did not seem to increase TE events (RR 0.65, 95% CI [0.33, 1.30]—4 studies, 2190 participants) and resulted in less bleeding (RR 0.41, 95% CI [0.22, 0.78]—3 studies, 2126 participants) compared to anticoagulation continuation or heparin bridging. The GRADE assessment was moderate. Similar results were found in non‐randomized studies, but the quality of the evidence was low. Possible strategy‐specific effects were identified: forgoing heparin bridging seemed beneficial, but these effects were less clear with other strategies.ConclusionInterrupting anticoagulation in patients requiring invasive procedures did not seem to result in harm and protected against major bleeding. Uncertainty remains regarding the safety of this strategy in indications other than atrial fibrillation and in moderate‐ to high‐risk surgery.Study registrationhttp://www.en.anaesthesie.usz.ch/research/Pages/Study‐protocols.aspx
Incidence and Risk Factors for Postoperative Delirium in Patients After Hepatectomy
Authors: Park Sung Ae , Tomimaru Yoshito , Shibata Asuka , Miyagawa Shinichi , Noguchi Kozo , Dono Keizo 
Published: June 2017

AbstractBackgroundsPostoperative delirium is a common complication after surgery. However, the incidence and risk factors associated with delirium after liver resection have not been clarified. Thus, this study aimed to investigate the incidence and risk factors for delirium in patients that underwent liver resections.MethodsThis study included 196 consecutive patients that underwent a liver resection. Groups with and without delirium were compared to identify differential patient characteristics. Multivariate regression analysis was used to identify independent factors that significantly influenced the development of postoperative delirium.
ResultsPostoperative delirium developed in 44 (22.4%) of the 196 patients. Majority of incidents occurred on postoperative day 2, and mean duration was 4.2 ± 5.5 days. Patients with delirium exhibited the following features: advanced age, low serum albumin levels, a high probability of a positive test for anti‐hepatitis C virus antibody, cerebrovascular disorders, cardiovascular diseases, diabetes mellitus, use of benzodiazepines, and previous history of delirium. Multivariate analysis revealed that the delirium development was significantly correlated with age, serum albumin level, presence of cerebrovascular disorder, use of benzodiazepines, and a previous history of delirium.ConclusionsThis study clarified the incidence and risk factors for delirium after liver resection. These results would contribute to prediction and treatment of delirium.
Quality of Recovery After Low‐Pressure Laparoscopic Donor Nephrectomy Facilitated by Deep Neuromuscular Blockade: A Randomized Controlled Study
Authors: Özdemir‐van Brunschot Denise M. D. , Scheffer Gert J. , van der Jagt Michel , Langenhuijsen Hans , Dahan Albert , Mulder Janneke E. E. A. , Willems Simone , Hilbrands Luuk B. , Donders Rogier , van Laarhoven Cees J. H. M. , d’Ancona Frank A. , Warlé Michiel C. 
Published: June 2017

AbstractBackgroundThe use of low intra‐abdominal pressure (<10 mmHg) reduces postoperative pain scores after laparoscopic surgery.ObjectiveTo investigate whether low‐pressure pneumoperitoneum with deep neuromuscular blockade improves the quality of recovery after laparoscopic donor nephrectomy (LDN).Design, setting and participantsIn a single‐center randomized controlled trial, 64 live kidney donors were randomly assigned to 6 or 12 mmHg insufflation pressure. A deep neuromuscular block was used in both groups. Surgical conditions were rated by the five‐point Leiden‐surgical rating scale (L‐SRS), ranging from 5 (optimal) to 1 (extremely poor) conditions. If the L‐SRS was insufficient, the pressure was increased stepwise.Main outcome measureThe primary outcome measure was the overall score on the quality of recovery‐40 (QOR‐40) questionnaire at postoperative day 1.ResultsThe difference in the QOR‐40 scores on day 1 between the low‐ and standard‐pressure group was not significant (p =. 06). Also the overall pain scores and analgesic consumption did not differ. Eight procedures (24%), initially started with low pressure, were converted to a standard pressure (≥10 mmHg). A L‐SRS score of 5 was significantly more prevalent in the standard pressure as compared to the low‐pressure group at 30 min after insufflation (p <. 01).ConclusionsLow‐pressure pneumoperitoneum facilitated by deep neuromuscular blockade during LDN does not reduce postoperative pain scores nor improve the quality of recovery in the early postoperative phase. The question whether the use of deep neuromuscular blockade during laparoscopic surgery reduces postoperative pain scores independent of the intra‐abdominal pressure should be pursued in future studies.Trial registrationThe trial was registered at clinicaltrial.gov before the start of the trial (NCT02146417).
The Benefits of a Wound Protector in Preventing Incisional Surgical Site Infection in Elective Open Digestive Surgery: A Large‐Scale Cohort Study
Authors: Itatsu Keita , Yokoyama Yukihiro , Sugawara Gen , Kamiya Satoaki , Terasaki Masaki , Morioka Atsushi , Iyomasa Shinsuke , Shirai Kazuhisa , Ando Masahiko , Nagino Masato 
Published: June 2017

AbstractBackgroundThe objective of this study was to evaluate the benefits of wound protectors (WPs) in preventing incisional surgical site infection (I‐SSI) in open elective digestive surgery using data from a large‐scale, multi‐institutional cohort study.MethodsPatients who had elective digestive surgery for malignant neoplasms between November 2009 and February 2011 were included. The protective value of WPs against I‐SSI was evaluated.ResultsA total of 3201 patients were analyzed. A WP was used in 1022 patients (32%). The incident rate of I‐SSI (not including organ/space SSI) was 9%. In the univariate and the multivariate analyses for perioperative risk factors for I‐SSI, the use of WP was an independent favorable factor that reduced the incidence of I‐SSI (odds ratio 0.73, 95% confidence interval 0.55–0.98. P = 0.038). The subgroup forest plot analyses revealed that WP reduced the risk of I‐SSI only in patients aged 74 years or younger, males, non‐obese patients (body mass index <25 kg/m2), patients with an American Society of Anesthesiologists score of 1/2, patients with a previous history of laparotomy, non‐smokers, and patients who underwent colon and rectum operations. In patients who underwent colorectal surgery, the postoperative hospital stay was significantly shorter in patients with WP than those without WP (median 13 vs. 15 days, P = 0.040). In terms of the depth of SSI, WP only prevented superficial I‐SSI and did not reduce the incidence of deep I‐SSI.ConclusionsWP is a useful device for preventing superficial I‐SSI in open elective digestive surgery.Trial registration numberUMIN000004723.
Integrating Regional Management Needs into a Mid-Atlantic Shorelines Research Project
Authors: Turner Elizabeth , Jordan Thomas 
Published: June 2017

Abstract
We provide an example of how one estuarine research project engaged regional managers to help guide the research towards the needs of managers and policymakers dealing with shoreline management in the Mid-Atlantic region of the USA. Elements of the approach that contributed to success included a well-targeted initial request for proposals, a review process that included management input both as a review criterion and on the review panel, a careful process in choosing advisory members at the appropriate level in the agencies, regular opportunities for interactions between the management advisory group and the science team, and active involvement of a program manager as liaison throughout the life of the project. Engagement of a management advisory group changed some of the scientific approaches, helped to communicate results, and formed a foundation for incorporation into regional management and initiatives.
Diffusion engineering of ions and charge carriers for stable efficient perovskite solar cells
Authors: Bi Enbing , Chen Han , Xie Fengxian , Wu Yongzhen , Chen Wei , Su Yanjie , Islam Ashraful , Grätzel Michael , Yang Xudong , Han Liyuan 
Published: June 2017

AbstractLong-term stability is crucial for the future application of perovskite solar cells, a promising low-cost photovoltaic technology that has rapidly advanced in the recent years. Here, we designed a nanostructured carbon layer to suppress the diffusion of ions/molecules within perovskite solar cells, an important degradation process in the device. Furthermore, this nanocarbon layer benefited the diffusion of electron charge carriers to enable a high-energy conversion efficiency. Finally, the efficiency on a perovskite solar cell with an aperture area of 1.02 cm2, after a thermal aging test at 85 °C for over 500 h, or light soaking for 1,000 h, was stable of over 15% during the entire test. The present diffusion engineering of ions/molecules and photo generated charges paves a way to realizing long-term stable and highly efficient perovskite solar cells.
INO80 exchanges H2A.Z for H2A by translocating on DNA proximal to histone dimers
Authors: Brahma Sandipan , Udugama Maheshi I. , Kim Jongseong , Hada Arjan , Bhardwaj Saurabh K. , Hailu Solomon G. , Lee Tae-Hee , Bartholomew Blaine 
Published: June 2017

AbstractATP-dependent chromatin remodellers modulate nucleosome dynamics by mobilizing or disassembling nucleosomes, as well as altering nucleosome composition. These chromatin remodellers generally function by translocating along nucleosomal DNA at the H3–H4 interface of nucleosomes. Here we show that, unlike other remodellers, INO80 translocates along DNA at the H2A–H2B interface of nucleosomes and persistently displaces DNA from the surface of H2A–H2B. DNA translocation and DNA torsional strain created near the entry site of nucleosomes by INO80 promotes both the mobilization of nucleosomes and the selective exchange of H2A.Z–H2B dimers out of nucleosomes and replacement by H2A–H2B dimers without any additional histone chaperones. We find that INO80 translocates and mobilizes H2A.Z-containing nucleosomes more efficiently than those containing H2A, partially accounting for the preference of INO80 to replace H2A.Z with H2A. Our data suggest that INO80 has a mechanism for dimer exchange that is distinct from other chromatin remodellers including its paralogue SWR1.