bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell based therapeutic approach in vascular surgery: application and review
Authors: Rocca Aldo , Tafuri Domenico , Paccone Marianna , Giuliani Antonio , Zamboli Anna Ginevra Immacolata , Surfaro Giuseppe , Paccone Andrea , Compagna Rita , Amato Maurizo , Serra Raffaele , Amato Bruno 
Published: October 2017

AbstractMultipotent stem cells - such as mesenchymal stem/stromal cells and stem cells derived from different sources like vascular wall are intensely studied to try to rapidly translate their discovered features from bench to bedside. Vascular wall resident stem cells recruitment, differentiation, survival, proliferation, growth factor production, and signaling pathways transduced were analyzed. We studied biological properties of vascular resident stem cells and explored the relationship from several factors as Matrix Metalloproteinases (MMPs) and regulations of biological, translational and clinical features of these cells. In this review we described a translational and clinical approach to Adult Vascular Wall Resident Multipotent Vascular Stem Cells (VW-SCs) and reported their involvement in alternative clinical approach as cells based therapy in vascular disease like arterial aneurysms or peripheral arterial obstructive disease.
The National Institute of Environmental Health Sciences Superfund Research Program: a model for multidisciplinary training of the next generation of environmental health scientists
Authors: Carlin Danielle J. , Henry Heather , Heacock Michelle , Trottier Brittany , Drew Christina H. , Suk William A. 
Published: October 2017

Abstract
The National Institute of Environmental Health Sciences (NIEHS) Superfund Research Program (SRP) funds university-based, multidisciplinary research on human health and environmental science and engineering with the central goals to understand how hazardous substances contribute to disease and how to prevent exposures to these environmental chemicals. This multi-disciplinary approach allows early career scientists (e.g. graduate students and postdoctoral researchers) to gain experience in problem-based, solution-oriented research and to conduct research in a highly collaborative environment. Training the next generation of environmental health scientists has been an important part of the SRP since its inception. In addition to basic research, the SRP has grown to include support of broader training experiences such as those in research translation and community engagement activities that provide opportunities to give new scientists many of the skills they will need to be successful in their field of research. Looking to the future, the SRP will continue to evolve its training component by tracking and analyzing outcomes from its trainees by using tools such as the NIEHS CareerTrac database system, by increasing opportunities for trainees interested in research that goes beyond US boundaries, and in the areas of bioinformatics and data integration. These opportunities will give them the skills needed to be competitive and successful no matter which employment sector they choose to enter after they have completed their training experience.
A smoothed EM-algorithm for DNA methylation profiles from sequencing-based methods in cell lines or for a single cell type
Authors: Lakhal-Chaieb Lajmi , Greenwood Celia M.T. , Ouhourane Mohamed , Zhao Kaiqiong , Abdous Belkacem , Oualkacha Karim 
Published: October 2017

AbstractWe consider the assessment of DNA methylation profiles for sequencing-derived data from a single cell type or from cell lines. We derive a kernel smoothed EM-algorithm, capable of analyzing an entire chromosome at once, and to simultaneously correct for experimental errors arising from either the pre-treatment steps or from the sequencing stage and to take into account spatial correlations between DNA methylation profiles at neighbouring CpG sites. The outcomes of our algorithm are then used to (i) call the true methylation status at each CpG site, (ii) provide accurate smoothed estimates of DNA methylation levels, and (iii) detect differentially methylated regions. Simulations show that the proposed methodology outperforms existing analysis methods that either ignore the correlation between DNA methylation profiles at neighbouring CpG sites or do not correct for errors. The use of the proposed inference procedure is illustrated through the analysis of a publicly available data set from a cell line of induced pluripotent H9 human embryonic stem cells and also a data set where methylation measures were obtained for a small genomic region in three different immune cell types separated from whole blood.
A Density Functional Theory Study of New Boron Nanotubes
Authors: Chen Zhao-Hua , Xie Zun 
Published: October 2017

Abstract
Using first-principles calculations, a series of new boron nanotubes (BNTs), which show various electronic properties, were theoretically predicted. Stable nanotubes with various chiral vectors and diameters can be formed by rolling up the boron sheet with relative stability [H. Tang and S. I. Beigi, Phys. Rev. B 82, 115412 (2010).]. By increasing the diameter for BNT, the stability is enhanced. The calculated density of states and band structures demonstrate that all the predicted BNTs are metallic, regardless of their diameter and chirality. The multicentre chemical bonds of the relatively stable boron sheet and BNTs are analysed using the deformation electron density. Within our study, the BNTs all have metallic conductive characteristics, in addition to having a low effective quality and high carrier concentration, which are very good nanoconductive material properties and could be combined to form high-power electrodes for lithium-ion batteries such as those used in many modern electronics.
Isomer Identification in Flames with Double-Imaging Photoelectron/Photoion Coincidence Spectroscopy (i2PEPICO) using Measured and Calculated Reference Photoelectron Spectra
Authors: Pieper Julia , Schmitt Steffen , Hemken Christian , Davies Emma , Wullenkord Julia , Brockhinke Andreas , Krüger Julia , Garcia Gustavo A. , Nahon Laurent , Lucassen Arnas , Eisfeld Wolfgang , Kohse-Höinghaus Katharina 
Published: October 2017

Abstract
Double-imaging photoelectron/photoion coincidence (i2PEPICO) spectroscopy using a multiplexing, time-efficient, fixed-photon-energy approach offers important opportunities of gas-phase analysis. Building on successful applications in combustion systems that have demonstrated the discriminative power of this technique, we attempt here to push the limits of its application further to more chemically complex combustion examples. The present investigation is devoted to identifying and potentially quantifying compounds featuring five heavy atoms in laminar, premixed low-pressure flames of hydrocarbon and oxygenated fuels and their mixtures. In these combustion examples from flames of cyclopentene, iso-pentane, iso-pentane blended with dimethyl ether (DME), and diethyl ether (DEE), we focus on the unambiguous assignment and quantitative detection of species with the sum formulae C5H6, C5H7, C5H8, C5H10, and C4H8O in the respective isomer mixtures, attempting to provide answers to specific chemical questions for each of these examples. To analyze the obtained i2PEPICO results from these combustion situations, photoelectron spectra (PES) from pure reference compounds, including several examples previously unavailable in the literature, were recorded with the same experimental setup as used in the flame measurements. In addition, PES of two species where reference spectra have not been obtained, namely 2-methyl-1-butene (C5H10) and the 2-cyclopentenyl radical (C5H7), were calculated on the basis of high-level ab initio calculations and Franck-Condon (FC) simulations. These reference measurements and quantum chemical calculations support the early fuel decomposition scheme in the cyclopentene flame towards 2-cyclopentenyl as the dominant fuel radical as well as the prevalence of branched intermediates in the early fuel destruction reactions in the iso-pentane flame, with only minor influences from DME addition. Furthermore, the presence of ethyl vinyl ether (EVE) in DEE flames that was predicted by a recent DEE combustion mechanism could be confirmed unambiguously. While combustion measurements using i2PEPICO can be readily obtained in isomer-rich situations, we wish to highlight the crucial need for high-quality reference information to assign and evaluate the obtained spectra.
Material Testing Apparatus and Procedures for Evaluating Freeze-Thaw Resistance of Asphalt Concrete Mixtures
Authors: Ho Chun-Hsing , Martin Linares Cristina Pilar , Shan Junyi , Almonnieay Anas 
Published: October 2017

Abstract
This paper presents material testing procedures using an ASTM C666 (Standard Test Method for Resistance of Concrete to Rapid Freezing and Thawing) apparatus to evaluate resistance of asphalt concrete (AC) mixtures with respect to freeze-thaw (F-T) cycles. The ASTM C666 apparatus is mostly used for testing F-T resistance of pervious concrete, but it can be an ideal device to replace the currently used AASHTO T283, Standard Method of Test for Resistance of Compacted Asphalt Mixtures to Moisture-Induced Damage, as it was never intended to simulate F-T resistance for asphalt mixtures. To evaluate the effectiveness of the ASTM C666 apparatus in determination of F-T resistance of asphalt mixtures, two types of AC materials were sampled from an asphalt paving project: rubberized modified asphalt (RMA) and fiber reinforced asphalt (FRA). All specimens were prepared in the Materials Laboratory of Northern Arizona University, and their F-T resistance was tested using an ASTM C666 apparatus at six designed cycles: 0, 100, 150, 200, 250, and 300 cycles. After each desired cycle is complete, specimens were removed from the ASTM C666 apparatus and then tested for their stiffness using a bending beam rheometer (BBR). The viscoelastic reposes of asphalt mixtures tended to be less significant after 150 F-T cycles. The field evaluation of local asphalt paving associated with climatic F-T cycle data and F-T test results indicate that surface conditions and cracking progress of the asphalt pavements do have closer agreement with the increase of F-T cycles. The ASTM C666 apparatus is capable of providing F-T conditioning of the specimens. In combination of the BBR device and the corresponding procedure, the thermal properties of the mix (e.g., stiffness at 60 s or relaxation modulus function) can be measured and determined. The testing procedures and results are promising and prone to the purposes of F-T resistant simulation. The findings presented in this paper provide a positive trend for future research focusing on the evaluation of long-term F-T durability of asphalt mixtures.
Efficient Prioritization of Multiple Causal eQTL Variants via Sparse Polygenic Modeling
Authors: Nariai Naoki , Greenwald William W , DeBoever Christopher , Li He , Frazer Kelly A 
Published: October 2017

AbstractExpression quantitative trait loci (eQTL) studies have typically used single-variant association analysis to identify genetic variants correlated with gene expression. However, this approach has several drawbacks: causal variants cannot be distinguished from nonfunctional variants in strong linkage disequilibrium, combined effects from multiple causal variants cannot be captured, and low-frequency (&lt;5% MAF) eQTL variants are difficult to identify. While these issues possibly could be overcome by using sparse polygenic models, which associate multiple genetic variants with gene expression simultaneously, the predictive performance of these models for eQTL studies has not been evaluated. Here, we assessed the ability of three sparse polygenic models (Lasso, Elastic Net, and BSLMM) to identify causal variants, and compared their efficacy to single-variant association analysis and a fine-mapping model. Using simulated data, we determined that, while these methods performed similarly when there was one causal SNP present at a gene, BSLMM substantially outperformed single-variant association analysis for prioritizing causal eQTL variants when multiple causal eQTL variants were present (1.6- to 5.2-fold higher recall at 20% precision), and identified up to 2.3-fold more low frequency variants as the top eQTL SNP. Analysis of real RNA-seq and whole-genome sequencing data of 131 iPSC samples showed that the eQTL SNPs identified by BSLMM had a higher functional enrichment in DHS sites and were more often low-frequency than those identified with single-variant association analysis. Our study showed that BSLMM is a more effective approach than single-variant association analysis for prioritizing multiple causal eQTL variants at a single gene.
A lógica do ser de Hegel
Authors: Wohlfart João Alberto 
Published: October 2017

Resenha de: Hegel, G. W. F. Ciência da lógica: 1. A doutrina do ser. Tradução deChristian Iber, Marloren L. de Miranda, Federico Orsini e Agemir Bavaresco(Coordenador). Petrópolis, RJ: Vozes; Bragança Paulista, SP: Ed.Universitária São Francisco, 2016. 464 p. ISBN 9788532653086.************************************************************************************************************************** Com a tradução, os falantes da língua portuguesa têm em mãos uma obra filosófica estruturante do pensamento moderno e uma das mais importantes da História da Filosofia. Temos agora e nossas mãos, em língua portuguesa, uma obra de difícil acesso do pensamento hegeliano e que um filósofo de língua portuguesa leria com muita dificuldade. A tradução, ora disponibilizada, tenta conciliar a difícil linguagem hegeliana escrita em alemão com a fluência típica do nosso português, permitindo uma compreensão mais ou menos fácil por parte do falante da língua portuguesa.
PARIMOS EM PORTUGAL: A VIVÊNCIA DO SERVIÇO DE SAÚDE POR IMIGRANTES BRASILEIRAS
Authors: Oliveira Eliany Nazaré , Lopes Roberlândia Evangelista , Cavalcante Maria Michele Bispo , Felix Tamires Alexandre , Neto Félix Fernando Monteiro , Moreira Roberta Magda Martins 
Published: October 2017

Objetivou-se narrar as experiências da assistência em saúde durante o parto de imigrantes brasileiras que vivem em Portugal. Abordagem qualitativa com o método Netnográfico constituiu a metodologia. A comunidade de escolha foi um grupo do Facebook – brasileiras que vivem em Portugal- e a coleta das informações ocorreu durante o fórum de discussão: “Parimos em Portugal, relatando a minha experiência”. Nos resultados emergiram 04 temáticas e 08 categorias de analise. A maioria das experiências das mulheres brasileiras evidenciaram os aspectos positivos do parto e dos serviços e um pequeno grupo revelou os entraves e aspectos negativos. Destaca-se a necessidade de conhecimento com mais detalhes dos itinerários de imigrantes grávidas e os desfechos sobre seus partos, para assim, implementar ações de apoio a este grupo. Sugere-se a criação de um observatório sobre pré-natal, parto e puerpério de imigrantes brasileiras sob a coordenação do Consulado do Brasil em Portugal.
TRABALHO NOTURNO NA VIDA DOS ENFERMEIROS
Authors: Da Silva Alidne Pinheiro , Carvalho Emilene Santos de , Cardim Adryanna 
Published: October 2017

O trabalho noturno na área da saúde é uma das formas de organizar o serviço de maneira a atender a demanda da população pelos serviços de saúde e prestar cuidado ininterrupto. Este ritmo de trabalho repercute diretamente na qualidade de vida destes profissionais. O objetivo geral desse trabalho é analisar as repercussões do trabalho noturno na vida dos enfermeiros. Trata-se de um estudo em caráter de revisão integrativa da literatura, pelo levantamento de 17 estudos publicados entre 2010 a 2016, em revistas indexadas nas bases de dados nacionais. Os dados foram analisados segundo a Análise de Conteúdo proposta por Bardin, assim emergiram três categorias: (01) implicações do trabalho noturno na saúde; (02) dificuldades do trabalho noturno na organização do trabalho; (03) repercussões do trabalho noturno na vida dos enfermeiros acerca das relações familiares em contrapartida aos aspectos positivos inerentes ao trabalho noturno destes profissionais. Os resultados apontam que o trabalho em turnos, principalmente no turno noturno, pode alterar algumas funções orgânicas nos indivíduos por alterar o ritmo do corpo humano. Os aspectos negativos relacionados com o trabalho noturno desenvolvido pelo enfermeiro envolvem as condições de que os funcionários do noturno sofrem um isolamento no que se refere a intercomunicação com outros setores, os quais não funcionam em esquema de plantão. O enfermeiro do turno noturno sofre a dificuldade de manter o convívio social devido às implicações decorrentes do horário de trabalho, associadas à sonolência constante e irritabilidade. Por outro lado, identificou-se que ao trabalhar no período noturno, o enfermeiro lida com a questão de flexibilidade de horários, o que lhe possibilita um duplo vínculo empregatício. Sendo assim conclui-se que é fundamental pensar em estratégias que possibilitem aos enfermeiros trabalhadores noturnos melhores condições de trabalho.
PERFIL DE PACIENTES ATENDIDOS EM EMERGÊNCIA HIPERTENSIVA EM UM HOSPITAL PÚBLICO DE SALVADOR
Authors: Franco Lenon Cardoso , Faustino Tássia Nery 
Published: October 2017

As emergências hipertensivas (EH) são entidades clínicas caracterizadas pela elevação aguda e significativa da pressão arterial (PA) associada a sintomas graves que evidenciam lesões de órgãos-alvo. Esse estudo objetivou traçar o perfil dos pacientes atendidos em emergência hipertensiva em um hospital público de Salvador. Trata-se de um estudo transversal descritivo. Os dados foram coletados entre 03/11/15 e 03/02/16, através do prontuário e processados no programa SPSS versão 21®. A estatística descritiva foi utilizada para análise dos dados. A amostra constituiu-se de 57 pacientes. A média de idade encontrada foi de 66,9 anos, com predominância do sexo feminino (52,6%) e da cor parda (93,0%). Aproximadamente 68,4% dos pacientes apresentavam histórico de Hipertensão Arterial Sistêmica (HAS). As EHs diagnosticadas foram o acidente vascular cerebral (AVC) isquêmico (61,4%), seguido do AVC hemorrágico (29,8%), da insuficiência cardíaca congestiva (5,3%) e do infarto agudo do miocárdio (3,5%). 28,1% desses pacientes evoluíram com complicações. Em relação aos valores da PA encontrados na admissão, a média de pressão sistólica foi de 189,8 mmHg, enquanto que a média de pressão diastólica foi de 105,7 mmHg. Conclui-se que os AVCs, especialmente os isquêmicos, foram as EH mais frequentes na amostra. Faz-se necessário a efetivação de medidas de prevenção dos fatores de risco associados à HAS, assim como direcionadas ao controle dos níveis pressóricos para redução do número de atendimentos por emergência hipertensiva e demais complicações das doenças cardiovasculares.
Safety, tolerability and pharmacokinetic profile of recombinant human tissue kallikrein, DM199, after intravenous and subcutaneous administration in healthy volunteers
Authors: Alexander-Curtis Michelle , Duan Jianmin , Seeklander Ashley , Scott Simon , Norton Nicola , Wong Chin Lin , Salman Sam , Verdoorn Todd A. 
Published: October 2017

<p class="abstract"><strong>Background:</strong> DM199 is a recombinant form of human tissue kallikrein (KLK1) that is being developed for ischemia-related diseases such as acute ischemic stroke. KLK1 is an important serine protease that promotes vasodilation and microcirculation in multiple tissues. Preclinical stroke studies demonstrate that KLK1 treatment promotes vasodilation, angiogenesis, prevents inflammation, and cerebral cell death<span lang="EN-IN">. </span></p><p class="abstract"><strong>Methods:</strong> The safety and tolerability, as well as the pharmacokinetic profile of DM199 was investigated in a Phase 1B clinical trial following an intravenously (IV) or subcutaneous (SC) administration. Part A was a single ascending IV infusion of DM199 and Part B involved a single IV infusion and single SC dose in two different groups<span lang="EN-IN">.</span></p><p class="abstract"><strong>Results:</strong> For both routes of administration, DM199 was found to be safe and well tolerated at all doses given, albeit the PK profile differed between routes with respect to the time to maximum concentration and plasma half-life. Importantly, DM199 did not influence blood coagulation parameters, suggesting it could be safely used with other stroke treatments like tPA<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> Together, these results support the design of future studies to test the efficacy of DM199 in ischemic related diseases including in acute ischemic stroke (AIS).</p>
Assessing the reporting quality of randomized-controlled clinical trials involving novel oral anticoagulants in patients with atrial fibrillation based on the CONSORT statement
Authors: Arvanitaki Alexandra D. , Mantzouratou Polyxeni , Zintzaras Elias 
Published: October 2017

<p class="abstract"><strong>Background:</strong> Inadequate reporting of the published randomized controlled trials (RCTs) may restrict the generalizability of treatment effectiveness and tolerability of non-vitamin K antagonist oral anticoagulants (NOACs) in patients with atrial fibrillation (AF). The main objective of this study was to assess the reporting quality of RCTs for efficacy and safety of NOACs vs. warfarin in patients with AF based on the consolidated standards of reporting trials (CONSORT) statement.</p><p class="abstract"><strong>Methods:</strong> Pubmed was searched for relevant english-language RCTs. Eligible articles included pivotal RCTs and articles reporting results from sub-populations or post-hoc secondary analysis of the pivotal trials (non-pivotal trials). Eligible articles were assessed according to 37-item/sub-item checklist of CONSORT statement 2010. The assessment was overall and according to trial’s type, NOAC treatment and impact factor (IF) of journals.</p><p class="abstract"><strong>Results:</strong> Search identified 92 articles eligible for evaluation. Half of CONSORT items were reported by more than 90% of the articles and 25% of items were reported in all articles. The majority of pivotal studies (94%) answered &gt;75% of CONSORT items, while only half of non-pivotal studies had similar compliance (p&lt;0.01). NOACs showed similar pattern in reporting quality (p&gt;0.05), while IF had a significant effect in quality (p&lt;0.01). </p><p><strong>Conclusions:</strong> RCTs for efficacy and safety of NOACs vs. warfarin in AF patients found to be well reported. Though, the quality of reporting is affected by type of trial and journals’ IF.</p>