bluuebunny/crossref_metadata_2025_split huggingface dataset:
O60 SURVIVAL DISPARITIES AMONG INDIGENOUS GROUPS WITH HTN LINKED TO THEIR POPULATION CONCENTRATION
Authors: Quintero Baiz Adalberto Elias , Herrera Parra Lina Johana , Urina Jassir Manuel , Valbuena García Ana María , Quintero Martínez Juan Andrés , Gómez Mesa Juan Esteban , Acuña Merchán Lizbeth Alexandra , Urina Triana Miguel Alberto 
Published: September 2024

Background and objective:
The indigenous groups are considered minority populations, primarily residing in rural areas. Cardiovascular disease stands as the leading cause of mortality, affecting native populations as well. This study aims to compare the overall survival (OS) rates among patients diagnosed with hypertension (HTN) in four Colombian departments where the population concentration of indigenous groups is over 10% compared to departments where it is less than 1%.

Methods:
Longitudinal retrospective cohort study. Population: Indigenous adults diagnosed with HTN from July 1st, 2014, to June 30 th, 2015, from the National Registry of Chronic Kidney Disease (NRCKD). The follow-up period was until July 30, 2023. We grouped indigenous communities according to their population concentration calculated by the Observatory of the Colombian Presidential Program for Human Rights. The probability of global survival from the date of diagnosis was estimated using Kaplan-Meier analysis. An unadjusted Royston Parmar flexible regression model was fitted. Right-censoring was defined as abandonment or completion of follow-up without death occurring.

Results:
67,353 indigenous prevalent cases were identified from July 1st, 2022 to June 30th, 2023, representing an HTN prevalence of 2.76%. Among them, 48.90% are in Cauca, Nariño, La Guajira, and Córdoba. Natives of Nariño registered a higher proportion of GFR stages 3 and 4, calculated using the CKD-EPI formula, compared to departments with a concentration of less than 1% (48.30% and 3.15% vs. 8.08% and 0.45% respectively). 2.600 cases were included in the survival analysis. Natives residents from Nariño and Cauca had the highest risk of all-cause mortality (HR = 7.66; 95% CI 3.33 – 17.59 and HR = 7.36; 95% CI 3.26 – 16.61) compared to groups living in departments with <1% concentration.

Conclusions:
In the Colombian health system, the hazard of all-cause mortality is higher for indigenous individuals with HTN living in Nariño and Cauca compared to those living in departments with less than 1% of the indigenous population.
O78 UNRAVELING THE RELATIONSHIP BETWEEN HYPERTENSION AND LIPOPROTEIN(A): INSIGHTS FROM THE GAELp(a) REGISTRY
Authors: Arrupe Matias , Renna Nicolás Federico , Cobo Augusto Lavalle , Mata Gabriela , Schreier Laura , Nogueira Juan Patricio , Prado Aldo , Gimenez Sergio , Lynch Santiago , Masson Walter , Soumoulou Juan Bautista , Corral Pablo 
Published: September 2024

Introduction:
Hypertension (HT) and elevated levels of lipoprotein(a) (Lp(a)) are both significant risk factors for cardiovascular disease. Understanding the relationship between these factors can provide valuable insights into cardiovascular risk stratification. This study aims to analyze the association between Lp(a) levels and HT in hypertensive patients, with a focus on identifying predictors of major adverse cardiovascular events (MACE) within this population.

Methods:
Patients included in the Argentine Group for the Study of Lp(a) [GAELp(a)], who had a diagnosis of hypertension were selected for this study. Demographic characteristics, anthropometric variables, cardiovascular risk factors, laboratory variables, and the presence of cardiovascular disease were assessed. Lp(a) levels were measured in mg/dL or nmol/L, with values exceeding 50 mg/dL or 125 nmol/L classified as elevated. Multivariate analysis was conducted to identify predictors of MACE within the study population.

Results:
A total of 334 hypertensive patients with recorded Lp(a) levels were included in the analysis. Thirty-eight percent of the patients exhibited elevated Lp(a) levels. In the multivariate analysis, predictors of MACE were male sex (OR 2.36, 95% CI 1.33-4.16), current smoker (OR 3.29, 95% CI 1.56-6.96), and type 2 diabetes (OR 2.86, 95% CI 1.43-5.72). However, no significant association was found between MACE and elevated Lp(a) levels. Additionally, it was observed that a substantial proportion (71.56%) of the study population were taking statins.
CONCLUSION: This study underscores the importance of considering multiple risk factors, including sex, smoking status, and diabetes, in assessing cardiovascular risk among hypertensive patients. While elevated Lp(a) levels did not emerge as a predictor of MACE in this population, further research is warranted to elucidate the role of Lp(a) in cardiovascular risk stratification.
O86 EFFECTIVENESS OF A MHEALTH (MOBILE-BASED) INTERVENTION FOR THE MANAGEMENT OF CARDIOVASCULAR DISEASES IN SOUTH ASIAN COUNTRIES: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Bhattarai Buna Bhandari , Thapa Poshan , Maharjan Preeti , Subedi Aastha , Pradhan Pranil Man Singh , Tandan Meera 
Published: September 2024

Background:
Cardiovascular disease (CVDs) is the leading cause of preventable death and disability, accounting for 18.6 million deaths and 393 million DALYs in 2019. The effectiveness of mobile health (mHealth) interventions for managing CVD in South Asia is poorly documented. This systematic review evaluates the impact of mHealth on cardiovascular health outcomes in this region.

Methods:
We conducted a systematic search of MEDLINE, EMBASE, CINAHL, Web of Science, and Scopus, covering the period from January 2000 to December 2023. Our search focused on studies employing mobile-based interventions, such as apps, SMS, video conferencing, or phone calls, to improve cardiovascular outcomes, including blood pressure, medication adherence, and physical activity. Data were synthesised using a random-effects meta-analysis, estimating summary hazard ratios (HRs) and 95% confidence intervals (CIs). This review was registered in PROSPERO (CRD42022340907).

Results:
We identified 1483 studies, of which 14 met our inclusion criteria, encompassing 30,939 participants (17,240 intervention; 14,984 control). Participants ages ranged from 46.4 to 60.6 years. Six studies reported improvement in systolic blood pressure (SBP), one reported improvement in cholesterol, two reported change in self-reported physical activity, and three reported improvement in medical adherence. Meta-analysis revealed a significant reduction in systolic blood pressure (SBP) by -2.32 (95% CI: -4.25 to -0.40; P=0.02) in the intervention arm. No significant changes were observed in diastolic blood pressure (DBP) or medication adherence, with DBP showing a reduction of -1.13 (95% CI: -1.69 to 1.42; P=0.87) and medication adherence an effect size of 0.44 (95% CI: -0.06 to 0.94; P=0.08).

Conclusions:
mHealth interventions in South Asia show promise in reducing SBP among individuals with CVD, though effects on DBP and medication adherence are less pronounced. The observed benefits are constrained by high heterogeneity and a limited number of studies, indicating the need for further research to consolidate these findings and explore additional CVD outcomes.
O95 HYPERTENSIVE RESPONSE TO EXERCISE RELATIVE-TO-FITNESS AND LEFT VENTRICULAR HYPERTROPHY ARE ASSOCIATED WITH INCREASED RISK OF CARDIOVASCULAR EVENTS: EVIDENCE FROM THE EXERCISE STRESS TEST COLLABORATION (EXERTION) STUDY
Authors: Silva Ruiz Catalina , Sharman James E. , Otahal Petr , Staton Tony , Wahi Sudhir , Hare James L. , Selvanayagam Joseph , Venn Alison , Marwick Thomas H. , Schultz Martin 
Published: September 2024

Background.
A hypertensive response to exercise (HRE) is associated with a high prevalence of left ventricular hypertrophy (LVH), both being related to an increased risk of cardiovascular disease (CVD). However, these associations may be influenced by aerobic capacity (fitness). This study aimed to determine if an HRE considered relative-to-fitness and LVH are associated with increased risk for CVD events.

Methods.
Records for 4,307 individuals (aged 58.6±12.7 years, 52.0% male) who underwent exercise stress echocardiography were linked to administrative health datasets (hospital and emergency admissions) to ascertain CVD events (n=458, mean follow-up, 44.8±25.9 months). LVH presence/absence (LVH+/LVH-) was defined as LV mass index adjusted for body surface area around a cut point of ≥115 g/m2 for men and ≥95 g/m2 for women. HRE presence/absence (HRE+/HRE-) relative-to-fitness was defined as peak systolic blood pressure (SBP) divided by peak metabolic equivalents around a cut point of ≥90th percentile. Survival analysis using Cox-proportional hazard regression was used to compare CVD event rates across the four groups defined by the combinations of HRE+/HRE- with LVH+/LVH-, adjusted for age, sex, pre-exercise SBP, and CVD history.

Results.
Compared to the reference group (HRE-/LVH-), there was a stepwise increase in CVD event rate (Figure 1) across the following groups: HRE+/LVH- [Adjusted HR(95%CI), 1.34(1.02-1.76)], HRE-/LVH+ [Adjusted HR(95%CI), 2.1(1.6-3.76)], HRE+/LVH+ [Adjusted HR(95%CI), 2.55(1.64-3.97)]. Conclusion. Individuals with both HRE considered relative-to-fitness and LVH are at the highest risk of CVD events, greater than either clinical presentation alone. These results emphasise the need to address an HRE and low fitness in people with LVH to improve CVD risk management.
O97 RESPONSE TO AEROBIC TRAINING MAY DIFFER BETWEEN ELDERLY MEN AND WOMEN WITH TREATED HYPERTENSION
Authors: Azevêdo Luan , Silva-Junior Natan , Costa Luiz , Brito Leandro , Forjaz Claudia 
Published: September 2024

Background and objective.
Hypertension incidence increases with aging, with expressive enhancement in women after the menopause due to the important physiological changes induced by the estrogen levels decline. Aerobic training is recommended for lowering blood pressure (BP) in men and women with hypertension. However, the possible gender-related differences in training responses have been poorly investigated, especially in elderly patients. Therefore, the objective of this study was to analyze responses to aerobic training in elderly men and women with treated hypertension.

Methods:
Thirty-one elderly hypertensives (15 women, 68±6ys and 16 men, 66±7ys) who were taking regular antihypertensive medication for at least 4 months participated in the study. They underwent 10 weeks of an aerobic training designed in accordance with the guidelines’ recommendations for hypertension (i.e. 3 session/week, cycle ergometer, 30-45 min, moderate intensity). Before and after the training period, peak oxygen uptake (VO2peak, cardiopulmonary exercise test), BP (auscultatory), systemic hemodynamics (CO2 rebreathing technique) and vascular function (brachial doppler ultrasound) were assessed. In each group (men and women), the training effects were evaluated using paired t-tests or Wilcoxon tests, considering p<0.05 as significant.

Results:
Aerobic training increased aerobic capacity in both sexes (men = 20.8±4.2 vs. 21.8±4.8 ml.kg-1.min-1, p=0.04 and women = 15.3±2.6 vs. 16.4±2.3 ml.kg-1.min-1, p=0.01). In men, systolic BP and systemic vascular resistance decreased (129±13 vs. 125±12 mmHg, p=0.003 and 21.0±3.8 vs. 18.9±4.1 u, p=0.02), while flow mediated dilation increased (5.5±2.9 vs. 7.2±3.1%, p=0.01) after the training period. On the other hand, in women, none of these variables changed with the training (124±15 vs. 126±12 mmHg, p=0.92; 23.2±5.5 vs. 23.5±5.6 u, p=0.80; and 4.2±3.2 vs. 5.4±3.5%, p=0.10). The other variables assessed did not change in either group.

Conclusions:
The proposed aerobic training program increased aerobic capacity in both male and female elderly hypertensives, but improved BP, systemic vascular resistance, and endothelial function only in males. Key-words: aerobic training, gender, blood pressure, hypertension. Financial Support: CAPES-0001, CNPq-302309/2022-5, and FAPESP- 2022/12605-3.
O103 ANTENATAL AND NEONATAL EXPOSURES AND CHILDHOOD HYPERTENSION: FINDINGS FROM THE BOSTON BIRTH COHORT
Authors: Makker Kartikeya , Kuieper Jordan , Hong Xiumei , Brady Tammy , Aziz Khyzer , Wang Xiaobin 
Published: September 2024

Background:
Early-life factors impact the development of hypertension (HTN). Impact of antenatal exposures, prematurity and subsequent early life exposures (including those in the neonatal intensive care unit (NICU)) on the development of HTN warrants further investigation.
Objective: 1. Expand our prior findings on the association of maternal cardiometabolic conditions with childhood HTN in the Boston Birth Cohort (BBC). 2.Investigate the combined association between prematurity and NICU exposures with childhood HTN.

Methods:
We analyzed factors associated with childhood HTN up to 18 years. HTN was defined according to national guidelines. Composite categories were created based on gestational age and NICU comorbidities. Chi-square and ANOVA tests were used for categorical and continuous variables, respectively. Regression analyses explored the association with HTN, while repeated measures analysis assessed BP percentiles.

Results:
We analyzed 2461 infants (695 preterm), with a total of 19,689 repeated BP measurements. Maternal pre-existing diabetes, older maternal age, maternal stress in index pregnancy and chronic maternal stress, were positively associated with childhood HTN, after adjusting for important covariables.
HTN incidence (25.9% vs. 16.31%) was higher in children born preterm, with an inverse dose-response trend. Compared to children born term without NICU exposure, those born term with NICU stay (OR 1.65 CI: 1.03-2.65), and those born preterm with NICU stay even without complications (OR 1.84 CI:1.38-2.46) had higher odds of developing HTN. Preterm children with NICU stay had the highest odds of developing HTN (OR 2.36 CI: 1.38-4.04), if they also had one or more major comorbidities (sepsis, chronic lung disease, necrotizing enterocolitis and intraventricular hemorrhage).
Repeated measures analysis further revealed a positive association of systolic and diastolic BP percentiles with maternal cardiometabolic conditions, prematurity, and presence of NICU complications.
Results remained consistent after adjustment for child BMI.

Conclusion:
In this US minority cohort, we found various early life factors linked to childhood HTN. Notably, preterm infants with a history of major NICU complications were more likely to develop childhood HTN.
O107 A LONGITUDINAL STUDY ON THE IMPACT OF CHILDHOOD ELEVATED BLOOD PRESSURE ON TARGET ORGAN HEALTH IN ADOLESCENCE: THE EXAMIN YOUTH SA STUDY
Authors: Kruger Ruan 
Published: September 2024

Background and objective:
Primary hypertension in children is becoming a global threat for the growing economic burden of hypertension management in adulthood and sustainable healthcare. We determined the associations of adolescent blood pressure (BP) with target organ damage markers (carotid intima-media thickness (CIMT) and left ventricular mass index (ilVM)) over a four year period, stratified by childhood BP status at baseline.

Methods:
We included 421 Black and 307 White South African adolescents (mean age: 11.04 years) with complete follow-up data for BP, CIMT and iLVM. Standard anthropometric measures and basic demographic information were collected.

Results:
Children were stratified by baseline BP status, i.e., normotensive; n=454 (57.5% Black and 57.7% female) and elevated BP; n=274 (58.4% Black and 52.2% female), with comparable proportions of ethnicity (p=0.81) and sex (p=0.15). Systolic BP (by 6mmHg; p<0.001), diastolic BP (by 3mmHg; p<0.001) and perfusion pressure (by 4mmHg; p<0.001) as well as sex-specific body mass index for age z-scores (BAZ; p<0.001) were all higher in the elevated BP compared to normotensive group. Groups were comparable for age (p=0.78), CIMT (p=0.28) and iLVM (p=0.64). In partial regression analysis (adjusting for ethnicity, sex, follow-up age and BAZ), systolic BP correlated positively with CIMT (r=0.125; p=0.041) and iLVM (r=0.184; p=0.002) in the elevated BP group only. Backward multiple adjusted linear regression analysis (adjustment for perfusion pressure at baseline, age, sex, ethnicity and BAZ) showed adverse associations of systolic BP with CIMT (β=0.126; p=0.046) and iLVM (β=0.199; p=0.001), and diastolic BP with iLVM (β=0.130; p=0.002), only in children with elevated BP at baseline.

Conclusion:
Elevated BP in early childhood contributes to the long-term impact on target organ health during adolescence independent of sex and ethnicity, while the association of BP with iLVM seems to be moderated by excess adiposity.
P005 CHILDREN WITH REPAIRED COARCTATION OF THE AORTA: FOLLOW-UP AND HYPERTENSIO5
Authors: Vaccari Marina , Maldonado Laura , Sardella Angela , Moros Claudio , Romo Miriam 
Published: September 2024

Background and objective:
Coarctation of the aorta (CoA) is a congenital heart disease with high morbidity and mortality due to cardiovascular disease even after adequate therapeutic management. A fundamental factor is the development of high blood pressure over the years. The objective of this work is to analyze the blood pressure phenotype of the population under follow-up in a high blood pressure clinic.

Methods:
Retrospective review of medical records of patients aged 0 to 22 years with CoA corrected by surgery or interventional catheterizations, which were followed up between January 2017 and February 2023 in the high blood pressure clinic of a pediatric center. Variables to analyze: age at the time of correction, technique, time since correction, associated cardiac or extracardiac pathologies, office blood pressure, left ventricular hypertrophy. In patients with adequate height and tolerance to the procedure: Ambulatory Blood Pressure Monitoring (ABPM) and pulse wave velocity study were performed.

Results:
142 medical records were reviewed (see table 1). Two groups were formed according to the age of the patients due to the possibility of performing ABPM.
There were no significant differences between the age of surgical approach and the association with complex heart diseases between the groups.
The younger population presented a greater number of extended terminal anastomosis technique and increased concentric remodeling. The prevalence of hypertension and overweight obesity increased over the years.
The older group had 25% masked hypertension and 25% increased pulse wave velocity

Conclusion:
Our population has 28% of hypertension among those under 8 years of age and it increases to 46% among the eldest, coinciding with international reports that indicate that the evolution towards arterial hypertension in this population is progressive.
Lifelong follow-up of these patients with corrected CoA is important to detect recoarctation or the development of hypertension and act accordingly to improve morbidity and mortality.
P015 MULTICENTER, PROSPECTIVE, SINGLE-BLIND(SUBJECTS), NON-INFERIORITY VERIFICATION, CONFIRMATORY CLINICAL TRIAL FOR EFFECTIVENESS OF BLOOD PRESSURE ANALYSIS ARTIFICIAL INTELLIGENCE SOFTWARE THAT PREDICTS 4-WEEK BLOOD PRESSURE BASED ON 8-WEEK HOME BLOOD PRESSURE
Authors: Kim Ju Han 
Published: September 2024

Background:
Hypertension is the leading cause of cardiovascular complications. Hypertension requires transformative solutions that can help reduce the global burden of the disease. Artificial intelligence (AI) and machine learning, which have made a substantial impact on our everyday lives over the last decade may be the route to this transformation. The purpose of the current study is to evaluate the efficacy of future blood pressure (BP) predicting AI software.

Methods:
2,057 patients were enrolled in the Dr. Answer hypertension project. Dr. Answer consists of 21 AI medical software that cover eight major diseases including hypertension. The Dr. Answer hypertension software was based on the Sequence-to-Sequence machine learning model. Patients were enrolled in 1 tertiary center (Chonnam National University Hospital) and other 21 non-tertiary centers from September 2021 to November 2022. The main object of Dr Answer hypertension AI software was to predict the patients 4 week office BP according to the 8 week home BP data. The primary efficacy endpoint was the mean absolute error (MAE) of the predicted office BP data.

Results:
The total of 610 patients and 2,405 home BP data were finally evaluated in the current study model. The mean participant age was 65.5 ± 13.1 years and 314 (51.5%) were male. 4 week average systolic/diastolic BP MAE was 3.96 mmHg and 2.14mmHg. Meanwhile, 4 week average root mean squared error of systolic/diastolic BP was 5.81mmHg and 2.88mmHg. Mean value of systolic BP accuracy was 74.1% and diastolic BP accuracy was 91.4%.

Conclusion:
The current study result proved the effectiveness of the future office BP predicting model of Dr. Answer AI medical software.
P020 GENDER AND CARDIOLOGY: EVALUATION OF DISCRIMINATION, HARASSMENT AND LABOR INEQUALITY IN THE DOMINICAN REPUBLIC
Authors: Cruz Licurgo , Tejada-Toribio Fiodor , Urraca-Mata Juan , Paulino-Then Jorge , Taveras-Franco Alvaro , Gutiérrez-Martínez Anthony 
Published: September 2024

Introduction:
Gender disparity has been a topic of increasing interest and controversy in recent years. In the United States, women represent only 12.6% of cardiologists, a figure that reflects persistent inequalities in this specialty and often leads women to dismiss it as a viable career option. In addition, salary disparity remains an obvious problem, with a trend that tends to favor the male sex. On the other hand, in Japan, female cardiologists face professional limitations due to family and domestic responsibilities that restrict their development and advancement in the profession.
Objective: To analyze and understand the perceptions and experiences of discrimination, harassment and work obstacles among cardiologists in the Dominican Republic, with a focus on gender differences.

Methods:
An observational, descriptive and cross-sectional study was carried out, in which a sample was randomly selected from the directory of the Dominican Society of Cardiology. An online questionnaire was used to collect demographic and work-related information, as well as data on experiences of discrimination, harassment and professional obstacles.

Results:
A sample of 51 patients was obtained, with an average age of 47.8 years, of whom 56.9% were women. Thirty-six.4% of women reported experiencing discrimination, compared with 13.8% of men. In terms of employment barriers, 62.1% of men reported obstacles related to remuneration, despite having higher monthly earnings compared to women. Of the latter, 50.0% also faced difficulties in this aspect. With respect to work-life balance barriers, 40.9% of women and 13.8% of men reported them.

Conclusion:
The perception of disparities among cardiologists reveals a trend where men face barriers in economic development, while women struggle to find a work-life balance. This highlights the urgency of implementing proactive strategies to promote gender equality in cardiology and ensure an inclusive and equitable professional environment.