bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing the risk factors associated with nutritional status in patients with liver cirrhosis: A case-control study
Authors: Ji Yanping , Ding Qingbin , Bu Tianyi , Wang Kun , Zhang Jing , Wang Xue 
Published: September 2024

BACKGROUND: Cirrhosis is one of the most common clinical diseases in the world. The patient with cirrhosis has many complications, such as spontaneous peritonitis, hepatic encephalopathy. Malnutrition is one of the most common complications in patients with cirrhosis, and it is also a key factor affecting the prognosis of patients. However, the research on cirrhosis malnutrition is relatively scarce. OBJECTIVE: This study aimed to explore the new factors of the liver cirrhosis with the nutritional status. METHODS: A total of 370 patients with liver cirrhosis were admitted to the Fourth Affiliated Hospital of Harbin Medical University from January 2019 to January 2023 were selected. Patients were assigned to the malnourished group and normal group. The weight, height, mid arm circumference (MAC) and triceps skinfold thickness (TSF) of the two groups were measured. Body mass index (BMI) and mid-arm muscle circumference (MAMC) were calculated. Furthermore, the Health Literacy Management Scale (HeLMS), biochemical indexes, incidence of complications, disease grade were also counted and the Royal Free Hospital-Nutrition Prioritization Tool were used to evaluate the nutritional status of the patient. RESULTS: A total of 370 patients was included in this study, including 177 malnutrition patients, accounting for 45.29%, and the scores and total scores of the patients in the malnutrition group were lower than those in the normal group. The measured values of Na[Formula: see text], Alb, PA, T-Bil, TC, TLC, Hb, and RBC were all lower than those of the normal group, and the difference was statistically significant. The overall complication rate of the patients in the malnourished group was 89.61%, and that of the normal group was 39.78%. Multifactorial logistic regression analysis was performed with nutritional level as the dependent variable (normal [Formula: see text] 0, malnutrition [Formula: see text] 1), and the above indicators of variability (Na[Formula: see text], Alb, PA, T-Bil, TC, PT, Hb, RBC, HG, and HeLMS scores) as the independent variables. The results showed that Na[Formula: see text], Hb were the influencing factors of nutritional level ([Formula: see text] 0.05). CONCLUSION: The incidence of malnutrition in cirrhotic patients included in this study was at a moderate level, and the nutritional literacy of these patients was low. In addition, the level of serum sodium, Hemoglobin can affect the nutritional level of patients with cirrhosis.
Cervical epidural blood patch treatment is a choice for spontaneous intracranial hypotension
Authors: Su Hui , Lan Xiaoyang , Cao Ya , Zhang Mingjie , Chen Xiaoyan , Lan Chen 
Published: September 2024

BACKGROUND: Epidural blood patch (EBP) is a minimally invasive and effective treatment for spontaneous intracranial hypotension (SIH). But, cervical epidural blood patch for SIH has little attention. OBJECTIVE: In this study, The clinical data was recorded and the treatment efficacy and safety of cervical EBP in SIH were evaluated. METHODS : Fifty-nine cases of intractable SIH were examined by computed tomography (CT) guided cervical EBP at the Chinese PLA General Hospital from August 2014 to March 2024. RESULTS: The mean age of the fifty-nine patients at symptom onset was 40.8 [Formula: see text] 9.5 years. 54/59 (91.5%) patients experienced orthostatic headache. Preoperative spine T2 scans with extensive fluid collection at the upper cervical region in 43/46 (93.5%). 45/59 (76.3%) patients had symptomatic relief with initial cervical EBP, and 14/59 (23.7%) patients received further cervical EBPs. In the first one to three days following the EBP procedure, 11 (18.6%) patients reported pain at the puncture site and 15 (25.4%) experienced neck pain. No other complications were observed during or after the procedure. At the latest follow-up, all patients showed good recovery. The mean follow-up was 28.9 [Formula: see text] 22.7 months. CONCLUSION: CT-guided cervical EBP is a effective and safe treatment for patients with intractable SIH, especially in patients who had extensive fluid collection at the upper cervical region.
Role and mechanism of LINC02390 and its potential target genes, CLECL1 and CD69, in immune microenvironment of lung adenocarcinoma
Authors: Luo Haichao , Chen Ran , Wang Changying , Chen Qitian 
Published: September 2024

BACKGROUND: Targeted therapy and immunotherapy has brought new hope to patients with lung adenocarcinoma (LUAD) with their applications. However, the prognosis of LUAD patients is still unpromising. OBJECTIVE: It is particularly important to find the biomarkers that can predict the prognosis of LUAD. In our previous study, we found that patients with high expression of LINC02390 had a better prognosis. The clinical significance of LINC02390 and its potential target genes, CLECL1 and CD69, in the prognosis of LUAD and its role in the immune microenvironment were explored. METHODS: Through the survival analysis, LINC02390 and its potential target genes, CLECL1 and CD69, were identified as good prognostic factors for LUAD. According to GO and KEGG analyses, LINC02390-related genes were identified potentially involved in immune-related signaling pathways. Gene mutations and their relationship with immune cell infiltration were verified through the online cbioportal and TIMER database. RESULTS: CD69 was found to positively associate with CD8 [Formula: see text] T cells and CLECL1 was also positively associated with CD4 [Formula: see text] T cells. A high expression of CD69 in CD8 [Formula: see text] T cells was identified through the single-cell sequencing dataset GSE111894. Finally, CLECL1 and CD69 were lowly expressed in clinical tissue samples with LUAD by immunohistochemical staining. CONCLUSIONS: LINC02390 and its possible target genes, CLECL1 and CD69, may be potential targets for the immunotherapy in LUAD patients.
A Bayesian network analysis of the probabilistic relationships between metabolically healthy obesity and cardiovascular disease risk under new diagnostic criteria
Authors: Chen Shuo , Wu Peixian , Peng Weiqun , Zhang Hongai 
Published: September 2024

BACKGROUND: The relationship between metabolically healthy obesity (MHO) and cardiovascular disease (CVD) risk remains debated. The critical point may be the lack of consensus on MHO’s definition and diagnostic criteria. OBJECTIVE: This study aimed to investigate the association of MHO status with arteriosclerosis-CVD (ASCVD) risk in Chinese under new diagnostic criteria. METHODS: Participants aged 35–79 in the 2009 China Health and Nutrition Survey cohort were included. The 10-year ASCVD risk was predicted by the prediction for ASCVD risk in China, and participants with a predicted risk of [Formula: see text] 10% were classified into the high-risk group. The Bayesian network (BN) models were constructed to characterize the multivariable probabilistic connections between metabolically obesity phenotypes and ASCVD risk. RESULTS: The 10-year ASCVD risk score and the proportion of individuals at ASCVD high risk were significantly different between metabolically obesity phenotypes ([Formula: see text] 0.001). BN reasoning results showed that MHO individuals were not significantly associated with a 10-year ASCVD risk. Among metabolically unhealthy individuals, the conditional probability of high ASCVD risk increased with the Body Mass Index (BMI), with the conditional probability of high ASCVD risk was 24.63% (95% CI: 22.81–26.55%), 32.97% (95% CI: 30.75–35.27%) and 40.2% (95% CI: 36.64–43.86%) for metabolically unhealthy normal weight (MUNW), metabolically healthy overweight weight (MHOW), and metabolically unhealthy obesity (MUO) group, respectively. Subgroup analysis showed that MHO individuals were at increased risk of CVD compared with metabolically healthy normal weight (MHNW) individuals only in females. CONCLUSION: These results showed that there was no significant increase in ASCVD risk of MHO phenotype based on the new diagnostic criteria, suggesting that MHO is in a relatively healthy state.
"Symphonic Etudies" and "Kreisleriana" by R. Schumann in the Representation of Biedermeyer and Romantic Cycling of Piano Miniatures
Authors: Vovchenko Hanna 
Published: September 2024

The purpose of this work is to highlight the Biedermeier components of Schumann's creative method in line with the pianistic directions of training of F. Wik, K. Wik-Schuman with the justification of the semantic direction of Schumann's works, which are inseparable from Biedermeier aesthetics, in turn, connected with the aesthetic indicators of romanticism. The methodological basis is the intonation approach of the school of B. Asafyev in Ukraine, comparative and hermeneutic prolongations of intonation in the works of D. Androsova, T. Verkina, O. Kozarenko, I. Kotlyarevskyi, I. Lyashenko, Liu Binjsan, O. Markova, O. Muravska, O. Ryzhova, O. Sokolova, with the use of scientific research methods: art history-analytical, descriptive-historical, cultural-regionalist, hermeneutic. Scientific novelty. For the first time in Ukraine, the Biedermeier side of R. Schuman's compositional thinking is emphasised in connection with his large cyclic works, in which the miniaturism of the components did not remove the romantic scale of thinking, but in the Biedermeier perspective, the avoidance of the author's stylistic egocentrism of expression. Conclusions. The two cycles of R. Schumann taken for analysis constitute a typical output of the composer's piano miniaturism, which stems from the idea of the “Oratorio for piano”, namely from his “Carnival”, in which the contrasts of tempo-genre juxtapositions, so prominent in romantic theatricality, appear here in the positive of Biedermeier imitation of Rococo sonata-suites, united by the kindness of communication in the latter, and here by the artistic disposition of the subject of the action. The piano version gravitates towards the “diamond” sounds of “light” pianism (Schumann repeatedly singled out Biedermeier in Chopin's playing, bypassing F. Liszt's orchestral discoveries), i.e. the Biedermeier component of the stylistic position of the author of “Carnival”, while the mysterious-theatrical contributions testify to an approach to the romantic palette.
The influence of modern technologies on creative processing, the sphere of sound art, and sound production
Authors: Yarosh Oleg 
Published: September 2024

The purpose of the article is to examine the influence of modern technologies on the creative process in the art of sound engineering and sound production. The research methodology to achieve this goal, a research methodology was applied that included a systematic literature review, definition of key concepts, technology impact analysis, data collection and analysis, formulation of conclusions and discussion, and provision of suggestions and recommendations. The scientific novelty consists in expanding the understanding of the influence of technologies on the art of sound engineering and sound production, their significant contribution to the transformation of the auditory space, the opening of new creative possibilities, and the modification of consumer perceptions of music. Conclusions confirm that modern technologies have a significant impact on the creative process in sound engineering and sound production. Using the latest tools and software enables artists to express their individuality and create unique musical images.
PERANAN PEMBELAJARAN DENGAN METAFORA DALAM MENINGKATKAN PRESTASI BELAJAR MATEMATIKA SISWA
Authors: Usmadi Usmadi , Ningsih Nova Fitria , Ergusni Ergusni 
Published: September 2024

Pembelajaran dengan metafora merupakan pembelajaran yang mengubah konsep matematika yang bersifat abstrak menjadi konkrit melalui kegiatan menghubungkan konsep dengan materi yang sudah diketahui sebelumnya dengan kehidupan sehari-hari. Tujuan dari penelitian ini adalah untuk mendeskripsikan peranan pembelajaran dengan metafora dalam meningkatkan prestasi belajar matematika siswa. Jenis penelitian ini adalah penelitian kepustakaan (library research), sedangkan metode penelitian ini adalah teknik dokumentasi yaitu menghimpun informasi dari buku, jurnal, skripsi, tesis, dan website internet yang relevan dengan topik penelitian dengan cara membaca, memahami, dan menganalisis sumber-sumber tersebut. Sumber data yang digunakan berupa sumber data utama dan pendukung yang berasal dari penelitian sebelumnya. Hasil temuan penelitian yaitu pembelajaran dengan metafora: (1) dapat mengubah konsep matematika yang abstrak menjadi konkrit melalui kegiatan menghubungkan konsep dengan materi sebelumnya dan kehidupan nyata, (2) dapat meningkatkan kemampuan penalaran matematis siswa, (3) dapat memberikan semangat kepada siswa untuk belajar dan membuat siswa tertarik terhadap matematika, (4) secara tidak langsung siswa mengalami proses berpikir metafora melalui tahapan CREATE (Connect, Relate, Explore, Analyze, Transform, dan Experience). Berdasarkan peranan pembelajaran dengan metafora akan membuat siswa lebih mudah memahami materi pelajaran dan menyelesaikan permasalahan yang diberikan, sehingga dapat meningkatkan prestasi belajar matematika siswa.
Вимоги до технічного обслуговування і ремонту обладнання систем, важливих для безпеки атомних станцій
Authors: Kukhotskyi O. , Gumeniuk D. , Ligotskyy O. , Potoskuiev O. , Shyshuta A. , Ostapovets A. 
Published: September 2024

Технічне обслуговування і ремонт обладнання систем важливих для безпеки атомних станцій входить у систему організаційно-технічних заходів забезпечення безпеки атомних станцій, які підлягають послідовній реалізації під час її експлуатації. Діяльність з технічного обслуговування і ремонту обладнання систем важливих для безпеки атомних станцій, зокрема і її оптимізація, повинна здійснюватися відповідно до чинних норм правил та стандартів, які враховують сучасні міжнародні підходи та практику.
У 2023 році з метою систематизації та приведення до актуального стану вимог з технічного обслуговування і ремонту обладнання систем важливих для безпеки атомних станцій розроблено та введено в дію новий нормативно-правовий акт «Вимоги до проведення технічного обслуговування і ремонту обладнання систем, важливих для безпеки АЕС». Новий документ встановлює основні вимоги забезпечення ядерної та радіаційної безпеки під час планування, підготовки, виконання та документування робіт з технічного обслуговування і ремонту обладнання систем, важливих для безпеки атомних станцій, з урахуванням ризик-інформованого підходу. Окрему увагу в документі відведено вимогам щодо можливості оптимізації технічного обслуговування і ремонту обладнання систем, важливих для безпеки атомних станцій, з метою підвищення їх ефективності без зниження безпеки атомних станцій. Документ розроблявся з 2020 року та на сьогодні введений в дію та застосовується в практичній діяльності. Метою цієї статті є огляд передумов розроблення нового документа, підходів до його розроблення та власне огляд документа та основних вимог, що провадженні в нормативно-регулюючу базу України після введення в дію документа.
Methodological Evaluation of Carbapenemase Detection by Different Methods
Authors: Gao Nana , Zhou Jing , Li Ge , Liu Runde , Lu Guoping , Shen Jilu 
Published: September 2024

Abstract
The global proliferation of carbapenemase-producing bacteria (CPB) has garnered significant attention worldwide. Early diagnosis of CPB and accurate identification of carbapenemases are crucial for preventing the spread of CPB and ensuring targeted antibiotic therapy. Therefore, efficient and accurate identification of carbapenemases is paramount in clinically treating diseases associated with CPB. In this study, 58 CPB strains were collected and detected using the DNA endonuclease-targeted CRISPR trans reporter (DETECTR) method, a rapid detection platform based on CRISPR-Cas12a gene editing and isothermal amplification. Additionally, four conventional methods (the APB/EDTA method, PCR, NG-test Carba 5, and GeneXpert Carba-R) were employed and compared against whole genome sequencing (WGS) results, considered the gold standard, to evaluate their efficacy in detecting carbapenemases. Detection by the APB/EDTA method revealed that 29 strains were positive for Class A serine endopeptidases, while 29 strains were positive for Class B metalloenzymes. The classification of these zymotypes was consistent with the sequencing result. All target carbapenemases for KPC were identified with 100% sensitivity using NG-test Carba 5, PCR, DETECTR, and GeneXpert Carba-R. In the case of NDM, both Xpert Carba-R and DETECTR showed a sensitivity of 100%. In contrast, NG-test Carba 5 and PCR had a slightly lower sensitivity of 96.7%, each missing one target carbapenemase. n this study, the APB/EDTA method is capable of identifying the zymotype classification but not the specific resistant genes, while Xpert Carba-R and DETECTR are able to detect all target carbapenemases.
Identification of a Novel Parvovirus in the Arctic Wolf (Canis lupus arctos)
Authors: Dai Ziyuan , Lu Qiang , Sun Mingzhong , Chen Hongmei , Zhu Rong , Wang Huiqing 
Published: September 2024

Abstract
A novel virus, temporarily named “Arctic wolf parvovirus” (AWPV), was discovered in a pharyngeal metagenomic library derived from an Arctic wolf (Canis lupus arctos) in China. The genome sequence was assigned GenBase accession number C_AA071902.1. AWPV has a genome comprised of 4,920 base pairs with a nucleotide composition of 36.4% A, 23.4% T, 18.2% G, and 22.0% C, with a GC content of 40.2%. Its structure resembles parvoviruses, containing two open reading frames: the nonstructural (NS) region encoding replication enzymes and the structural (VP) region encoding capsid protein. Pairwise sequence comparison and phylogenetic analysis suggest AWPV may represent a novel species within the genus Protoparvovirus. This discovery enhances our understanding of mammalian virus ecology and potential future infectious diseases.
Proyecto Memoria Viva ante el espejo: universidad, museos y patrimonio
Authors: Brito Montero Aimara , Capó Ortega María Elena , Sánchez Ortega Naydelín , Báez Fernández Darais 
Published: September 2024

Contribución al debate de revista PH 113 sobre Universidad, museo y patrimonio. Abordar la relación universidad, museo y patrimonio, en los momentos actuales, resulta esencial. La gestión del conocimiento y la formación de capacidades en torno a estas categorías han recibido una mayor atención. El establecimiento de normas jurídicas internacionales y nacionales que regulan concepciones, principios y pautas en función de la gestión, manejo, puesta en valor e interpretación del patrimonio han contribuido a ello. Sin embargo, los esfuerzos aún son insuficientes, si de patrimonio universitario se trata.
Strategi Pengembangan Keterampilan Hidup Warga Belajar Paket C Melalui Pelatihan Kaligrafi Di PKBM Al Mubarok 2 Genteng, Banyuwangi
Authors: Sugiharto Firsta Bagus , Al Mubarok Zaki , Thoif Mokh , Surandoko Tomas 
Published: September 2024

Program Pengembangan Keterampilan Hidup melalui pelatihan kaligrafi di PKBM Al Mubarok 2 Genteng Banyuwangi dirancang untuk meningkatkan keterampilan hidup (life skills) warga belajar Paket C. Pelatihan ini dimulai dengan identifikasi kebutuhan peserta dan penyusunan kurikulum yang mencakup teknik kaligrafi, manajemen waktu, kerja sama tim, serta keterampilan berwirausaha. Metode pembelajaran yang diterapkan adalah partisipatif, melibatkan demonstrasi langsung oleh instruktur, praktek mandiri, dan evaluasi berkala untuk memastikan pemahaman dan kemajuan peserta. Motivasi warga belajar diperkuat melalui pemberian sertifikat, penghargaan untuk karya terbaik, serta pameran hasil karya. Dukungan psikososial juga diberikan untuk membantu peserta mengatasi hambatan pribadi dan sosial. Evaluasi pelatihan dilakukan secara berkala melalui penilaian hasil karya, observasi, dan feedback dari peserta, yang kemudian digunakan untuk menyempurnakan program. Selain itu, PKBM Al Mubarok 2 menjalin kerjasama dengan komunitas seni lokal dan lembaga lainnya untuk memperluas akses dan peluang bagi peserta pelatihan. Hasil dari program ini menunjukkan peningkatan signifikan dalam keterampilan artistik, rasa percaya diri, dan peluang usaha bagi warga belajar. Pelatihan kaligrafi tidak hanya mengembangkan keterampilan teknis, tetapi juga membentuk karakter, kreativitas, dan kemampuan beradaptasi warga belajar dalam menghadapi tantangan kehidupan sehari-hari. Program ini membuktikan bahwa pendekatan yang komprehensif dan partisipatif dalam pelatihan keterampilan hidup dapat memberikan manfaat yang berkelanjutan bagi masyarakat.
Pemberdayaan Desa Nelayan Melalui Literasi Ekonomi Digital Untuk Mendukung Ekonomi Produktif Masyarakat Pulau Arar
Authors: Al Jumroh Siti Fatihaturrahmah , Nurteteng Nurteteng , Matahari Matahari , Witdianti Yeni , Ihram Ihram 
Published: September 2024

Desa nelayan kampung Arar sebagian masyarakatnya berpenghasilan sebagai nelayan dan pedagang hasil laut. Permasalahan prioritas dalam kegiatan ini adalah 1) Hasil laut yang diperdagangkan tidak laku terjual dan membusuk, 2) Pendapatan pedagang semakin memburuk, 3) Tidak adanya kemampuan dalam ekonomi digital, dan 4) Belum diterapkan inovasi teknologi informasi. Masyarakat kampung Arar belum menemukan solusi untuk mengatasi permasalahan-permasalan tersebut. Selain itu masyarakat juga terkendala pada masalah teknologi yaitu kurangnya pemahaman nelayan terhadap sistem teknologi informasi, sebagian besar nelayan belum memiliki smartphone, dan keterbatasan jaringan internet bukan berarti tidak memiliki akses jaringan internet. Mestinya pada masa ini pemanfaatan teknologi merupakan hal yang sudah lazim pada semua aspek kehidupan. Oleh karena itu, tim pengabdi berinisiatif membuat perubahan yang inovatif dalam bentuk teknologi informasi untuk mengatasi permasalahan tersebut, yakni dengan memberikan pendampingan dalam memasarkan hasil laut melalui teknologi digital. Dari hasil kuesioner evaluasi kegiatan diketahui bahwa peserta pelatihan dari jumlah total peserta 15 terdapat 9 orang peserta yang menyatakan pelatihan mengenai digital marketing ini mudah, 3 orang peserta yang menyatakan sedang, dan tidak ada peserta yang menyatakan sulit. Kegiatan menunjukkan bahwa pelatihan digital marketing ini mudah dipahami oleh masyarakat pulau Arar khususnya yang tergabung dalam BUMDES. Berdasarkan hasil pendampingan yang dilakukan dengan adanya beberapa kendala, maka perlu adanya tindak lanjut bentuk pengabdian yang dilakukan di kampung Arar ini, yakni berupa akses internet yang memadai.
Mengenal Budaya Lamongan Melalui Literasi Digital Berbasis Game Education Di Sekolah Dasar
Authors: Pramusinta Yulia , Viyanti Pratiwi , Fitriani Ayu Novi 
Published: September 2024

Pergeseran paradigma budaya lokal yang mulai luntur disebabkan oleh globalisasi mengakitbatkan budaya lokal tersisihkan dan terlupakan. Banyaknya siswa madrasah yang belum mengenal budaya lokal dan rendahnya kemampuan literasi siswa menjadi sebuah masalah yang harus segera diatasi. Pengenalan budaya lokal melalui literasi digital yang dikemas dengan games pembelajaran akan lebih menarik dan efisien dalam memecahkan masalah pembelajaran tersebut. Sasaran kegiatan ini ada siswa kelas 5 dan kelas 6 di MI Narative Quran Lamongan. Kegiatan pengabdian terdiri dari 4 tahapan yakni, analisis kebutuhan, persiapan, pelaksanaan, dan evaluasi. Kegiatan pengabdian ini melalui beberapa rangkaian kegiatan, antara lain 1) pada tahap analisis kebutuhan tim pengabdian melakukan wawancara dan observasi sekolah, 2) pada tahap perisiapan tim pengabdian membuat soal dan modul ajar bertema kearifan lokal Lamongan, 3) pada tahap pelaksanaan tim pengabdian mengimplementasikan pembelajaran berbasis kearifan lokal Lamongan melalui games education, dan 4) pada tahap evaluasi tim pengabdian mengevaluasi nilai games education siswa dan di dapatkan hasil nilai siswa pada kategori tinggi.