bluuebunny/crossref_metadata_2025_split huggingface dataset:
Direct thrombectomy as a salvage technique in free flap breast reconstruction
Authors: Hong Ki Yong , Chang Lan Sook , Chang Hak , Minn Kyung Won , Jin Ung Sik 
Published: October 2016

AbstractBackgroundBreast reconstruction with microvascular free tissue transfer has become a widely used method. Despite a high rate of success, a compromised flap necessitating re‐exploration can occur. Here, we introduce direct thrombectomy as a flap salvage technique, and compared the results with conventional thrombectomy.MethodsA total of 488 patients who underwent breast reconstruction using a free transverse rectus abdominis myocutaneous flap between March 2009 and February 2014 were retrospectively analyzed. Flap salvage was conducted by either conventional thrombectomy using a Fogarty catheter, or direct thrombectomy via either a side branch or additional incisions at the stump of the main pedicle at the distal end of the thrombus.ResultsFlap compromise necessitating re‐exploration due to extensive pedicle thrombosis was identified in 30 patients (6.1%). Direct thrombectomy was used in 9 patients, and conventional thrombectomy in 21 patients. Direct thrombectomy had a significantly higher success rate of flap salvage than conventional thrombectomy (88.9% vs. 47.6%; P = .049).ConclusionsIn the event of vascular thrombosis after free flap breast reconstruction, direct thrombectomy at the proximal pedicle stump beside the anastomosis opening appears to be an effective and reliable option that minimizes vessel trauma related to conventional catheter use. © 2016 Wiley Periodicals, Inc. Microsurgery 37:402–405, 2017.
Health Professionals' Perceptions of the Effects of Exercise on Joint Health in Rheumatoid Arthritis Patients
Authors: Halls Serena , Law Rebecca‐Jane , Jones Jeremy G. , Markland David A. , Maddison Peter J. , Thom Jeanette M. 
Published: October 2016

AbstractObjectivesAlthough exercise is an important factor in the management of rheumatoid arthritis (RA), research indicates that patients perceive that health professionals (HPs) are uncertain about the place of exercise in treatment and its relationship with joint damage. The present study investigated the perceptions of HPs regarding the effects of exercise on joint health in RA patients.MethodsA questionnaire investigating perceptions of exercise and joint health was distributed via professional networks and websites. Confirmatory factor analysis (CFA) was used to analyse questionnaire data and develop a focus group interview guide. Focus groups were conducted with multidisciplinary teams (MDTs) of rheumatology HPs and analysed using framework analysis.ResultsA total of 137 rheumatology HPs (95 female; 27–65 years of age) completed questionnaires. CFA showed that a four‐factor model provided a marginally acceptable fit. Analysis of four focus groups (n = 24; 19 female; 30–60 years of age) identified five themes relating to HPs' perceptions of exercise and joint health in RA patients: ‘Exercise is beneficial’, ‘Concerns about damage to joints’, ‘Patients have barriers to exercise’, ‘HP knowledge differs’ and ‘Patients may think service delivery is vague’.ConclusionsHPs were highly aware of the benefits and importance of exercise for RA patients. However, to remove the patient perception that HPs lack certainty and clarity regarding exercise it is important to ensure: (i) consistent promotion of exercise across the whole MDT; (ii) clear provision of information regarding rest, joint protection and exercise; (iii) HP education to ensure consistent, accurate knowledge, and understanding of the potential for conflicting advice when promoting exercise as part of an MDT. Copy © 2016 John Wiley & Sons, Ltd.
2‐deoxyglucose inhibits induction of chemokine expression in 3T3‐L1 adipocytes and adipose tissue explants
Authors: Grant Ryan W. , Boudreaux Jacqueline I. , Stephens Jacqueline M. 
Published: October 2016

ObjectiveTo determine the influence of glycolytic inhibition on the adipocyte inflammatory response.MethodsTo determine the effect of 2‐deoxyglucose (2‐DOG) on the inflammatory response, mature 3T3‐L1 adipocytes were co‐treated with 2‐DOG and LPS or TNF. To determine the effect of endoplasmic reticulum stress on TNF‐induced induction of chemokines, adipocytes were pretreated with thapsigargin or salubrinal. Chemokine mRNA levels were determined using quantitative real‐time PCR, and secretion of CCL2 was determined by Western blot.Results2‐DOG treatment reduced the ability of LPS and TNF to induce CCL2 mRNA levels and reduced secreted CCL2 protein levels in a dose‐dependent manner. A similar pattern of mRNA regulation was observed for other chemokines. The attenuation of TNF‐induced CCL2 mRNA levels occurred regardless of whether glucose or pyruvate was present in the media, suggesting that mechanisms other than glycolysis might mediate the observed effects. Treatment with the endoplasmic reticulum stressor thapsigargin and the endoplasmic reticulum signaling activator salubrinal reduced chemokine mRNA levels similarly to 2‐DOG.ConclusionsCollectively, our data indicate that 2‐DOG suppresses inflammatory chemokine induction in adipocytes. The effects of 2‐DOG do not seem to be linked to glycolysis but correlate with endoplasmic reticulum stress activation.
Modeling the potential of screen printed front junction CZ silicon solar cell with tunnel oxide passivated back contact
Authors: Chen Chia‐Wei , Hermle Martin , Benick Jan , Tao Yuguo , Ok Young‐Woo , Upadhyaya Ajay , Tam Andrew M. , Rohatgi Ajeet 
Published: October 2016

AbstractCarrier selective passivated contacts composed of thin oxide, n + polycrystalline Si and metal on top of a n‐Si absorber can significantly lower the recombination current density (Jorear ≤8 fA/cm2) under the contact while providing excellent specific contact resistance (5–10 mΩ‐cm2); 25.1% efficient small area cells with photolithography front contacts on boron doped selective emitter and Fz wafers have been achieved by Fraunhofer ISE using their tunnel oxide passivated contact (TOPCon) approach. This paper shows a methodology to model such passivated contact cells using Sentaurus device model, which involves replacing the TOPCon region by carrier selective electron and hole recombination velocities to match the measured Jorear of the TOPCon region as well as all the light IV values of the cell. We first validated the methodology by modeling a 24.9% reference cell. The model was then extended to assess the efficiency potential of large area TOPCon cells on commercial grade n‐type Cz material with screen‐printed front contacts. To use realistic input parameters, a 21% n‐type PERT cell was fabricated on Cz wafer (5 Ω‐cm, 1.5‐ms lifetime). Modeling showed that the cell efficiency will improve to only 21.6% if the back of this cell is replaced by the above TOPCon, and the performance is limited by the homogenous emitter. Efficiency was then modeled to improve to 22.6% with the implementation of selective emitter (150/20 Ω/sq). Finally, it is shown that screen printing of 40‐µm‐wide lines and improved bulk material (10 Ω‐cm, 3‐ms lifetime) can raise the single side TOPCon Cz cell efficiency to 23.2%. Copyright © 2016 John Wiley & Sons, Ltd.
Phenylene(vinylene) based fluorescent polymer for selective and sensitive detection of nitro‐explosive picric acid
Authors: Duraimurugan Kumaraguru , Siva Ayyanar 
Published: October 2016

ABSTRACTWe report the synthesis of phenylene(vinylene) based blue light emitting polymer by atom transfer radical polymerization with very good yield. Their photophysical properties were studied systematically with increasing polarities of solvent and sensing of nitro aromatics in solution and in vapor phase. The sensory properties of the polymer were studied toward various nitroaromatic compounds like nitrobenzene (NB), nitrotoluene (NT), dinitrobenzene (DNB), dinitrotoluene (DNT), nitro benzoic acid (NBA), 3‐nitro benzaldehyde (3‐NBA), trinitrotoluene (TNT), 4‐nitrophenol (NP), and picric acid (PA) in solution state. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3800–3807
Tunable, concentration‐independent, sharp, hysteresis‐free UCST phase transition from poly(N‐acryloyl glycinamide‐acrylonitrile) system
Authors: Käfer Florian , Lerch Arne , Agarwal Seema 
Published: October 2016

ABSTRACTPoly(N‐acryloylglycinamide‐co‐acrylonitrile) (poly(NAGA‐AN)) copolymers were synthesized using reversible‐addition‐fragmentation transfer polymerization. In contrast to poly(NAGA) the thermoresponsive behavior of poly(NAGA‐AN) shows a narrow cooling/heating hysteresis in water with a tunable cloud point, depending on the acrylonitrile amount in polymer. Furthermore, we showed that there is no significant effect of the solution concentration on the cloud point and stable phase transition behavior in electrolyte solutions, which is presumable controlled by forming stable micellar like structures as a result of the block/graft‐copolymer structure. This is in contrast to poly(NAGA) which shows a strong concentration dependent cloud point in aqueous solution with a broad cooling/heating hysteresis. © 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2017, 55, 274–279
Clinical outcomes of levalbuterol versus racemic albuterol in pediatric patients with asthma: Propensity score matching approach in a medicaid population
Authors: Yuan Jing , Lu Zhiqiang Kevin , Zhang Yanjun , Wu Jun , Love Bryan L. , Schulz Richard M. 
Published: October 2016

SummaryObjectiveRacemic albuterol and levalbuterol are used to treat acute episodes of asthma. The main objective of this study was to compare levalbuterol therapy to albuterol therapy on incidence rates of subsequent emergency department (ED) visits and hospitalizations.MethodWe conducted a retrospective cohort study of asthmatic children who had pharmacy refills for levalbuterol/albuterol in the South Carolina Medicaid database in 2002–2011. Children receiving levalbuterol were matched to those receiving albuterol using propensity score matching technique. For ED visits and separately for hospitalizations, multivariable negative binomial regression was used to estimate the two group‐specific incidence rates and the incidence rate ratio (IRR).ResultsA total of 8,172 asthmatic patients aged 2–18 years were identified in the South Carolina Medicaid database. During the 12‐month follow‐up period, the levalbuterol group had fewer asthma‐related ED visits and hospitalizations: 939 (11.49%) children had asthma‐related ED visits (levalbuterol: 8.76%; albuterol: 14.21%), and 89 (1.09%) children had asthma‐related hospitalizations (levalbuterol: 1.07%; albuterol: 1.12%). Comparing the levalbuterol group to the albuterol group, the adjusted IRR estimate was 0.57 (95% confidence interval [CI], 0.49–0.65) for of asthma‐related ED visits, and 0.93 (95%CI, 0.99–1.63) for hospitalizations. Children filling levalbuterol also had a lower IRR of all‐cause ED visit (0.88; 95%CI, 0.82–0.95), but similar IRR of all‐cause hospitalizations (1.08; 95%CI, 0.82–1.42).ConclusionThis observational study of children aged 2–18 demonstrated levalbuterol prescription fills were associated with reduced ED visits, but not hospitalizations. Additional research may be necessary to assess this association. Pediatr Pulmonol. 2017;52:516–523. © 2016 Wiley Periodicals, Inc.
Mechanical Properties of Composite AP/HTPB Propellants Containing Novel Titania Nanoparticles
Authors: Thomas James C. , Demko Andrew R. , Sammet Thomas E. , Reid David L. , Seal Sudipta , Petersen Eric L. 
Published: October 2016

AbstractModern chemical synthesis techniques have allowed for improved incorporation of nano‐scale additives into solid propellants. Various methods were implemented to incorporate titania nanoparticles into three representative ammonium perchlorate composite propellants (APCP), and the mechanical properties of each formulation were tested and compared to those of an analogous baseline. Advanced imaging techniques were applied to all particle synthesis methods to characterize particle size and particle network type and size. Uniaxial tensile testing was performed to measure propellant ultimate strength, ductility, and elastic modulus. In general, the addition of nano‐titania additives to the propellant decreased propellant strength and modulus, but improved ductility. Propellant formulations containing in‐situ titania exhibited an increase in ductility of 11 %, 286 %, and 186 % with a corresponding reduction in strength of 82 %, 52 %, and 17 % over analogous baselines. These trends corresponded to a simultaneous decrease in propellant density, indicating that when implementing nano‐sized additives, care must be taken to monitor the effect of the altered manufacturing techniques on propellant physical properties in addition to just monitoring burning rates. Tailoring of propellant manufacturing procedures and the addition of Tepanol bonding agent to an in‐situ APCP formulation fully recovered the propellant density and ultimate strength while retaining the enhanced ductility.
Investigation of Fireball Temperatures in Confined Thermobaric Explosions
Authors: Maiz Lotfi , Trzciński Waldemar A. , Paszula Józef 
Published: October 2016

AbstractNew composite metalized explosives were studied. The explosives consisted of two different types of macroscopic granular multi‐component RDX‐based formulations. In a 0.15 m3 explosion chamber, fireball temperature histories for numerous cylindrical pressed and layered charges made from the composites were determined using optical spectroscopy. For comparison, charges consisting of simple mixtures instead of the composites as well TNT and RDX phlegmatized (RDXph) charges were also studied. The influence of the structure of the macroscopic granular composite, the charge type (pressed charge or layered charge with an RDXph core), oxygen availability (air or argon atmosphere) and aluminum particle size on the fireball temperature and the combustion of the aluminum powder were determined. The measured temperatures were compared with the theoretical ones calculated by assuming different activity of the aluminum fuel.
Lessons from (co‐)evolution in the docking of proteins and peptides for CAPRI Rounds 28–35
Authors: Yu Jinchao , Andreani Jessica , Ochsenbein Françoise , Guerois Raphaël 
Published: October 2016

ABSTRACTComputational protein–protein docking is of great importance for understanding protein interactions at the structural level. Critical assessment of prediction of interactions (CAPRI) experiments provide the protein docking community with a unique opportunity to blindly test methods based on real‐life cases and help accelerate methodology development. For CAPRI Rounds 28–35, we used an automatic docking pipeline integrating the coarse‐grained co‐evolution‐based potential InterEvScore. This score was developed to exploit the information contained in the multiple sequence alignments of binding partners and selectively recognize co‐evolved interfaces. Together with Zdock/Frodock for rigid‐body docking, SOAP‐PP for atomic potential and Rosetta applications for structural refinement, this pipeline reached high performance on a majority of targets. For protein–peptide docking and interfacial water position predictions, we also explored different means of taking evolutionary information into account. Overall, our group ranked 1st by correctly predicting 10 targets, composed of 1 High, 7 Medium and 2 Acceptable predictions. Excellent and Outstanding levels of accuracy were reached for each of the two water prediction targets, respectively. Altogether, in 15 out of 18 targets in total, evolutionary information, either through co‐evolution or conservation analyses, could provide key constraints to guide modeling towards the most likely assemblies. These results open promising perspectives regarding the way evolutionary information can be valuable to improve docking prediction accuracy. Proteins 2017; 85:378–390. © 2016 Wiley Periodicals, Inc.
A lightweight authentication mechanism in MIP networks
Authors: Kim Green , Kim Youngse , Heo Ung , Kim Keecheon 
Published: October 2016

AbstractNumerous vulnerabilities threat the security of Mobile IP (MIP) networks. A variety of methods have been proposed to protect the MIP networks from the attacks. However, most of these methods are heavy and require significant time and resources. MIP is an essential element within the wireless mobile communication network that provide a fixed IP address. Among the changes from the existing standard IP network to the MIP network, security is a most essential one. Handover delay has been increased because of the complicated authentication and registration process. Because the essential goals of MIP are to provide seamless connection and real‐time services, the security vulnerability became the biggest problem for the real deployment. To solve this problem, this paper proposes a new lightweight authentication mechanism for the authentication, authorization, and accounting (AAA) infrastructure of MIP networks. In the original AAA authentication mechanism, mobile node (MN) must wait for a nonce from an AAA server in order to generate the session key, which be used for the security associations between MN and home agent and between MN and foreign agent. This paper introduces a new mechanism, which enables the unauthenticated MN to initiate a key generation process and create a secret key in advance. This mechanism facilitates key distribution by reducing cryptographic operations (76.68% improvement) and handover time (14.15% improvement). Copyright © 2016 John Wiley & Sons, Ltd.
RITA: RIsk‐aware Trust‐based Architecture for collaborative multi‐hop vehicular communications
Authors: Kerrache Chaker Abdelaziz , Calafate Carlos T. , Lagraa Nasreddine , Cano Juan‐Carlos , Manzoni Pietro 
Published: October 2016

AbstractTrust establishment over vehicular networks can enhance the security against probable insider attackers. Regrettably, existing solutions assume that the attackers have always a dishonest behavior that remains stable over time. This assumption may be misleading, as the attacker can behave intelligently to avoid being detected. In this paper, we propose a novel solution that combines trust establishment and a risk estimation concerning behavior changes. Our proposal, called risk‐aware trust‐based architecture, evaluates the trust among vehicles for independent time periods, while the risk estimation computes the behavior variation between smaller, consecutive time periods in order to prevent risks like an intelligent attacker attempting to bypass the security measures deployed. In addition, our proposal works over a collaborative multi‐hop broadcast communication technique for both vehicle‐to‐vehicle and vehicle‐to‐roadside unit messages in order to ensure an efficient dissemination of both safety and infotainment messages. Simulation results evidence the high efficiency of risk‐aware trust‐based architecture at enhancing the detection ratios by more than 7% compared with existing solutions, such as T‐CLAIDS and AECFV, even in the presence of high ratios of attackers, while offering short end‐to‐end delays and low packet loss ratios. Copyright © 2016 John Wiley & Sons, Ltd.
An Empirical Test of the Relational View in the Context of Corporate Venture Capital
Authors: Weber Christiana , Bauke Boris , Raibulet Virgil 
Published: October 2016

Research summaryThis study focuses on Dyer and Singh's (1998) relational view in the context of corporate venture capital (CVC) investors and their portfolio companies, who mutually strive for interorganizational rent generation. Aiming to better understand this relational rent‐generation process, our article entirely operationalizes and refines Dyer and Singh's (1998) model. While our findings attest strong explanatory power to the original model in the context of CVC investment relationships, they suggest the existence of additional relationships between the constructs of the relational view. Specifically, we identified relation‐specific assets as well as knowledge‐sharing routines as mediators between complementary resources and capabilities and relational rent.Managerial summaryIn this article, the relational view as an existing theory on interorganizational relationships is applied and tested using quantitative data in the context of corporate venture capital (CVC) investments. Our analysis confirms that relation‐specific assets and knowledge‐sharing routines, as well as complementary resources and capabilities, lead to relational rent. This is supernormal profit creation for both CVC investors and portfolio companies. The relationships are, however, not as straightforward as the original theory suggests, with complementary resources and capabilities being antecedents for knowledge‐sharing routines and relation‐specific assets which, subsequently, lead to the desired rent. Counterintuitively, informal self‐enforcing governance mechanisms (trust) appear to foster relationship satisfaction, but not necessarily create relational rent or immediate tangible benefits. Copyright © 2016 Strategic Management Society
The formal semantics of program slicing for nonterminating computations
Authors: Ward Martin , Zedan Hussein 
Published: October 2016

AbstractSince the original development of program slicing in 1979 there have been many attempts to define a suitable semantics, which will precisely define the meaning of a slice. Particular issues include handling termination and nontermination, slicing nonterminating programs, and slicing nondeterministic programs. In this paper we review and critique the main attempts to construct a semantics for slicing and present a new operational semantics, which correctly handles slicing for nonterminating and nondeterministic programs. We also present a modified denotational semantics, which we prove to be equivalent to the operational semantics. This provides programmers with 2 different methods to prove the correctness of a slice or a slicing algorithm and means that the program transformation theory and FermaT transformation system, developed last 25 years of research, and which has proved so successful in analyzing terminating programs, can now be applied to nonterminating interactive programs.
Lessons learned from 4‐year empowering project management with TALAIA OpenPPM
Authors: Mas Antonia , Mesquida Antoni‐Lluís , Jovanović Miloš , Barceló Joan 
Published: October 2016

AbstractKnowledge and experience are not the only prerequisite for a successful project; a well‐performing team using proper tools and techniques ensures efficient project management. Adequate tool is essential to support decision making in management of any organizational business units. TALAIA OpenPPM is an open‐source solution for managing projects, programs, and portfolios. SM2, founder of TALAIA OpenPPM, after 4 years of experience of the tool implementation in companies from different sectors, came to a conclusion that the successful adoption of the tool is strongly affected with existing maturity level of the project management processes established in the organization. Also, this article derives lessons learned by SM2 in expansion and opening of a new business line in the international market.