bluuebunny/crossref_metadata_2025_split huggingface dataset:
Role of KLF4 and SIAT7A interaction accelerates myocardial hypertrophy induced by Ang II
Authors: Yao Qiying , Hu Xinrui , Bian Tiantian , Zhang Qing , Xue Zhao , Lv Yuesheng , Ren Shupeng , Chen Yue , Zhang Dongmei , Chen Liang 
Published: October 2024

AbstractSialylation catalysed by sialyltransferase 7A (SIAT7A) plays a role in the development of cardiac hypertrophy. However, the regulatory mechanisms upstream of SIAT7A in this context remain poorly elucidated. Previous study demonstrated that KLF4 activates the SIAT7A gene in ischemic myocardium by binding to its promoter region. Nevertheless, the potential involvement of KLF4 in regulating SIAT7A expression in Ang II‐induced hypertrophic cardiomyocytes remains uncertain. This study seeks to deepen the underlying mechanisms of the KLF4 and SIAT7A interaction in the progression of Ang II‐induced cardiac hypertrophy. The results showed a concurrent increase in SIAT7A and KLF4 levels in hypertrophic myocardium of essential hypertension patients and in hypertrophic cardiomyocytes stimulated by Ang II. In vitro experiments revealed that reducing KLF4 levels led to a decrease in both SIAT7A synthesis and Sialyl‐Tn antigen expression, consequently inhibiting Ang II‐induced cardiomyocyte hypertrophy. Intriguingly, reducing SIAT7A levels also resulted in decreased KLF4 expression and suppression cardiomyocyte hypertrophy. Consistent with this, elevating SIAT7A levels increased KLF4 expression and exacerbated cardiomyocyte hypertrophy in both in vivo and in vitro experiments. Additionally, a time‐course analysis indicated that KLF4 expression preceded that of SIAT7A. Luciferase reporter assays further confirmed that modulating SIAT7A levels directly influenced the transcriptional activity of KLF4 in cardiomyocytes. In summary, KLF4 expression is upregulated in cardiomyocytes treated with Ang II, which subsequently induces the expression of SIAT7A. The elevated levels of SIAT7A, in turn, enhance the transcription of KLF4. These findings suggest a positive feedback loop between KLF4 and SIAT7A‐Sialyl‐Tn, ultimately promoting Ang II‐induced cardiac hypertrophy.
The Clash of the Policies: The Joint Effect of EU Cohesion Policy and Common Agricultural Policy on the Public Support for European Integration
Authors: Radojičić Nikola 
Published: October 2024

AbstractA vital element of the European Union (EU) political system is the idea of further European integration. Whilst most existing works investigate the effects of the Cohesion Policy (CP), only a handful of studies consider the effects of the Common Agricultural Policy (CAP) on citizens' support for European integration. In this contribution, I argue that these two largest EU redistribution policies neutralise each other in their effects on the citizens' support for European integration: the CP improves public support due to its positively perceived redistributive nature and positive externalities, whilst the CAP decreases public support due to due to a limited target audience, somewhat elitarian distribution of resources and bureaucratic complexities. Using regional‐level CP and CAP data for 2017 and Eurobarometer surveys for 2018 and 2019, the empirical findings of multilevel regressions show that the CAP counteracts the positive effects of the CP on citizens' support for further European integration. The findings are robust to including a wide range of control variables, sample size change and alternative specifications of key independent variables. These findings also hint that policy evaluations should not disregard the differences between various policy instruments.
Collective swimming pattern and synchronization of fish pairs (Gobiocypris rarus) in response to flow with different velocities
Authors: Yang Fan , Zeng Yuhong 
Published: October 2024

AbstractCollective behaviors in moving fish originate from social interactions, which are thought to be driven by beneficial factors, such as predator avoidance and reduced energy expenditure. Despite numerical simulations and physical experiments aiming at the hydrodynamic mechanisms and interaction rules, how shoaling is influenced by flow velocity and group size is still only partially understood. In this study, spatial distributions, kinematics, and synchronization states between pairs (smallest subsystem of a shoal) of Gobiocypris rarus were investigated in a recirculating swim tunnel with increasing flow velocities from 0.1 to 0.5 m/s (Ucrit = 0.6 m/s). Tests of single fish were also conducted as the control group. The results of spatial distributions showed that fish pairs preferred to swim in the side‐by‐side configuration under high flows, while under low flows the neighboring fish's positions were more uniformly distributed around the focal fish in the transverse direction. Kinematic analysis revealed that fish pairs adopted similar tail beats (i.e., frequency and Strouhal number) as single fish in low flows, while in high flows both the frequency and Strouhal number of fish pairs were slightly lower. Moreover, the synchronization rates of fish pairs were found to increase with flow velocities, suggesting that synchronized swimming may be beneficial, especially in high flows.
The effects of bank mergers on listed U.S. borrowers
Authors: Ji Shuangshuang , Mauer David C. , Zhang Yilei 
Published: October 2024

AbstractWe examine the effects of U.S. bank mergers on listed U.S. borrowers. Target bank borrowers receive lower loan spreads and no change in loan amount post‐merger in comparison to pre‐merger. In contrast, acquiring bank borrowers receive an increase in loan amount and a relatively small decrease in loan spread in the post‐merger period. Analysis shows that these benefits are available only when borrowers have bargaining power through lending relationships with non‐merging banks. We examine how borrower size, merger type, bank size, and borrower relationship intensity affect our results. Overall, our analysis suggests that efficiency gains from bank consolidation outweigh market power effects.
Prevalence of orthopaedic conditions in Rett syndrome: a systematic review and meta‐analysis
Authors: Galán‐Olleros M. , González‐Alguacil E. , Soto‐Insuga V. , Vara‐Arias M. T. , Ortiz‐Cabrera N. V. , Egea‐Gámez R. M. , García‐Peñas J. J. , Martínez‐Caballero I. ,   RTT‐HNJ, Rett Syndrome Multidisciplinary Group of Hospital Infantil Universitario Niño Jesús
Published: October 2024

AbstractBackgroundRett syndrome (RTT), a developmental disorder primarily affecting girls and linked to methyl‐CpG binding protein‐2 (MECP2) gene mutations, presents musculoskeletal abnormalities with varying prevalence across studies and age groups. Our aim was to delineate the prevalence of orthopaedic conditions in individuals with RTT.MethodThree databases were searched and independently screened by two reviewers to retrieve observational studies published after 2000 that recruited 10 or more patients diagnosed with RTT and reported the prevalence of any orthopaedic conditions (scoliosis, hip displacement, knee problems or foot deformities). A random‐effects meta‐analysis was performed to determine the pooled prevalence based on study weight.ResultsOf 867 screened studies, 21 studies involving 9997 girls with RTT (mean age 14.1 years; range, 3–38.5) met the inclusion criteria. The pooled prevalence of scoliosis was 64.5% [95% confidence interval (CI) 55.4–73.6%; I2 = 99%; P < 0.01], of hip displacement was 29.6% (95% CI 8.9–50.2%; I2 = 97%; P < 0.01) and of foot deformities was 53% (95% CI 17.5–89.2%; I2 = 98%; P < 0.01). Knee problems were reported in only one study. Scoliosis prevalence increased in studies with a high percentage of genetic testing and MECP2 positivity [69.1% (95% CI 58.9–79.2%; I2 = 99%; P < 0.01)], those with a mean age over 13 years [73% (95% CI 59.1–87%; I2 = 100%; P < 0.01)], and studies combining both variables [80.13% (95% CI 70.8–89.4%; I2 = 81%; P < 0.01)].ConclusionsThis meta‐analysis found that approximately two in three girls with RTT develop scoliosis, one in two exhibit foot deformities and one in three experience hip displacement. These findings enhance our understanding of the prevalence of orthopaedic conditions in RTT, which can guide the establishment of surveillance protocols, clinical guidelines and management strategies tailored to the needs of RTT patients.
It Takes a Village: Translating Management Ideas through an Ecology of Roles
Authors: Elmholdt Kasper Trolle , Nielsen Jeppe Agger , Wæraas Arild , Meyer Renate 
Published: October 2024

AbstractAlthough research has provided valuable insights into how management ideas circulate across contexts and undergo translation, the prevailing focus remains on the one‐directional journey from idea suppliers to adopting entities. In contrast, we advance an ecology of roles perspective to capture the dynamic relationships between multiple actors and roles in the translation process. To develop our argument, we draw from a 10‐year case study examining how the US‐born management idea of the leadership pipeline was translated into a domesticated version in Denmark, which became widely adopted but also contested and renewed. In analysing this case, we show how the same actors assumed an array of interdependent roles that dynamically shifted over time to circulate the idea. We identify three characteristics of an ecology of translation roles: multiplicity of roles, morphing of roles, and reciprocal authorization of roles. By advancing an ecology of roles perspective, our study contributes novel insights to the expanding literature on translation and recent work on translation ecosystems.
Patient Participation in Multidisciplinary Team Meetings in Residential Mental Health Services: An Explorative Study of Patients' Perception
Authors: Berben Kevin , Van Hecke Ann , Verhaeghe Sofie , Dierckx Eva 
Published: October 2024

ABSTRACTIntroductionThe lack of evidence of mental health patients' perception on patient participation in multidisciplinary team meetings (MTMs) is a potential threat to the person‐centeredness of care.AimTo explore the perceptions of mental health patients regarding patient participation in MTMs and to identify factors associated with these perceptions.MethodIn a cross‐sectional study, 127 former and 109 currently admitted mental health patients completed the Patient Participation during Team Meetings Questionnaire (PaPaT‐Q). The STROBE‐checklist was used for reporting the study.ResultsOverall, patients' perceptions were positive. Former patients expressed greater willingness to participate in MTMs, considered participation as more important, and felt more competent. These patients also exhibited a stronger preference for an autonomous role in medical decision making when participating in MTMs. The perception varied across factors such as gender, educational level, nature of psychological complaints and prior experience(s) with participation in MTMs.DiscussionThese findings may help mental healthcare professionals to become more aware to factors associated with mental health patients' perception of patient participation in MTMs.ImplicationsThe results can be used by mental healthcare professionals to motivate mental health patients in an even more tailor‐made basis to participate in MTMs when admitted in a hospital.
The effects of daylight saving time clock changes on accelerometer‐measured sleep duration in the UK Biobank
Authors: de Lange Melanie A. , Richmond Rebecca C. , Birnie Kate , Shapland Chin Yang , Tilling Kate , Davies Neil M. 
Published: October 2024

SummaryWe explored the effects of daylight saving time clock changes on sleep duration in a large accelerometer dataset. Our sample included UK Biobank participants (n = 11,780; aged 43–78 years) with accelerometer data for one or more days during the 2 weeks surrounding the Spring and Autumn daylight saving time transitions from October 2013 and November 2015. Between‐individual t‐tests compared sleep duration on the Sunday (midnight to midnight) of the clock changes with the Sunday before and the Sunday after. We also compared sleep duration on all other days (Monday–Saturday) before and after the clock changes. In Spring, mean sleep duration was 65 min lower on the Sunday of the clock changes than the Sunday before (95% confidence interval −72 to −58 min), and 61 min lower than the Sunday after (95% confidence interval −69 to −53). In Autumn, the mean sleep duration on the Sunday of the clock changes was 33 min higher than the Sunday before (95% confidence interval 27–39 min), and 38 min higher than the Sunday after (95% confidence interval 32–43 min). There was some evidence of catch‐up sleep after both transitions, with sleep duration a little higher on the Monday–Friday than before, although this was less pronounced in Autumn. Future research should use large datasets with longer periods of accelerometer wear to capture sleep duration before and after the transition in the same individuals, and examine other aspects of sleep such as circadian misalignment, sleep fragmentation or daytime napping.
Complementary feeding practices and nutritional status in infants living in Turkey: Iowa infant feeding attitude scale and complementary feeding index
Authors: Meral Koc Bilge , Ozlu Karahan Tugce , Arslan Yuksel Ezgi , Garipoglu Gokcen 
Published: October 2024

AbstractAlthough complementary feeding (CF) and maternal attitudes towards infant feeding are known to affect the nutritional status of infants during the neonatal period, studies in this field remain limited. The present study aimed to determine CF practices for infants aged 6–12 months who live in Turkey and maternal attitudes towards infant feeding. In addition, the effects of CF practices and maternal attitudes on the nutritional status of infants were examined. This study included 720 infants, of whom 289 were aged 6–8 months and 431 were aged 9–12 months. CF status was assessed using the CF index (CFI), and maternal attitudes towards infant feeding were measured using the Iowa infant feeding attitude scale (IIFAS). The weight and length measurements of infants were categorized using z‐scores. Infants with weight‐for‐age z‐score (WAZ) and weight‐for‐length z‐score (WLZ) of less than −2 standard deviation were categorized as malnourished. Mothers of malnourished infants were found to have lower CFI and IIFAS scores (p < 0.05). Consistency of fruit feeding and complementary foods in the first 3 days of CF was associated with WAZ. The mothers' level of knowledge about CF and appropriate CF practices significantly affects the nutritional status of infants. The tools used in the present study to monitor CF practices should be incorporated into public health programmes.
Strengthening implementation of integrated care for small and nutritionally at‐risk infants under six months and their mothers: Pre‐trial feasibility study
Authors: McGrath Marie , Girma Shimelis , Berhane Melkamu , Abera Mubarek , Hailu Endashaw , Bathorp Hatty , Grijalva‐Eternod Carlos , Woldie Mirkuzie , Abdissa Alemseged , Girma Tsinuel , Kerac Marko , Smythe Tracey 
Published: October 2024

AbstractAn integrated care pathway to manage small and nutritionally at‐risk infants under 6 months (u6m) and their mothers (MAMI Care Pathway) is consistent with 2023 WHO malnutrition guidelines and is being tested in a randomised controlled trial (RCT) in Ethiopia. To optimise trial implementation, we investigated contextual fit with key local stakeholders. We used scenario‐based interviews with 17 health workers and four district managers to explore perceived feasibility. Eighteen policymakers were also surveyed to explore policy coherence, demand, acceptability, evidence needs, opportunities and risks. The Bowen feasibility framework and an access to health care framework were adapted and applied. Health workers perceived the MAMI Care Pathway as feasible to implement with support to access services and provide care. The approach is acceptable, given consistency with national policies, local protocols and potential to improve routine care quality. Demand for more comprehensive, preventive and person‐centred outpatient care was driven by concerns about unmet, hidden and costly care burden for health services and families. Inpatient care only for severe wasting treatment is inaccessible and unacceptable. Support for routine and expanded components, especially maternal mental health, is needed for successful implementation. Wider contextual factors may affect implementation fidelity and strength. Policymakers cautiously welcomed the approach, which resonates with national commitments, policies and plans but need evidence on how it can work within varied, complex contexts without further system overstretch. A responsive, pragmatic randomised controlled trial will generate the most useful evidence for policymakers. Findings have informed trial preparation and implementation, including a realist evaluation to contextualise outcomes.
The costs and the potential allocation of costs of bouillon fortification: The cases of Nigeria, Senegal, and Burkina Faso
Authors: Vosti Stephen A. , Jarvis Michael , Anjorin Olufolakemi Mercy , Engle‐Stone Reina , Beye Maguette , Ishaya Faith , Koudougou Karim , Oni Blessing , Somda Hervé , Adams Katherine P. 
Published: October 2024

AbstractFood and condiment fortification programs are needed to address micronutrient deficiencies and their health, developmental, and mortality consequences; but these programs are never free. Knowing program costs and their allocation across stakeholders is essential to design and manage effective, efficient, and sustainable programs. We developed 10‐year hypothetical bouillon fortification program cost models for Nigeria, Senegal, and Burkina Faso that included start‐up and operational costs for government and industry, as well as premix costs generated by an embedded premix cost calculator to allow for alternative premix formulas in cost calculations. The main drivers of total costs were total bouillon consumption and the types and amounts of fortificants in the micronutrient premix. For a premix that meets 30% of Codex Nutrient Reference Values in 2.5 g of bouillon for vitamin A, folate, vitamin B12, zinc, and iron, the cost per metric ton of fortified bouillon was ∼$325 for all countries (∼$0.01 per 2.5 g serving). Annual start‐up costs ranged from ∼$324k (Burkina Faso) to ∼$455k (Nigeria); nonpremix annual operating costs ranged from ∼$108k (Burkina Faso) to ∼$3.9m (Nigeria); and annual premix costs varied from ∼$2.4m (Burkina Faso) to ∼$76m (Nigeria). In policy discussions, program costs should be set alongside nutritional benefits.
Graft Loss in Pediatric and Young Adult Kidney Transplantation in New Zealand: Who Is at Greatest Risk and When?
Authors: Selvathesan N. , Han D. Y. , Palmer S. C. , Dickens A. , Manley P. , Prestidge C. 
Published: October 2024

ABSTRACTBackgroundMuch is reported regarding the detrimental effect of transfer to adult services for adolescent and young adult (AYA) kidney transplant (KT) recipients. However, AYA recipient age independent of time post‐KT, and not relating to transfer of care, is also a strong predictor of graft loss. We assessed KT graft survival if experiencing solely pediatric (PO) or adult services (AO) versus transfer from pediatric to adult services (PTA).MethodsA retrospective cohort analysis of all first kidney transplant recipients between birth—24 years of age, from 2000 to 2019 in New Zealand. Participant identification and data were obtained via the Australia and New Zealand Dialysis and Transplantation registry. Primary outcome was graft survival stratified by service type. Cox proportional hazard modeling assessed independent risk factors of graft loss.ResultsTwo hundred forty‐four children and AYA with a median follow‐up of 7.3 years were included. Graft survival stratified by service provision group was not different. The incidence rate of graft loss was 37, 34, and 45 per 1000 persons per year for PO, PTA, and AO respectively. Crude age‐specific graft failure rates were highest for 22–24‐year‐olds with inferior outcomes starting from age 16, peaking at 24 years.ConclusionsOlder adolescence and young adulthood reflect a high‐risk period for KT loss. Transfer to adult services was not associated with worse graft survival compared to those experiencing either AO or PO alone. Improved models of care are needed to improve graft survival in this vulnerable population within New Zealand.
Identification of autophagy gene family in potato and the role of StATG8a in salt and drought stress
Authors: Zhu Xi , Majeed Yasir , Zhang Ning , Li Wei , Duan Huimin , Dou Xuemei , Jin Hui , Chen Zhuo , Chen Shu , Zhou Jiannan , Wang Qihua , Tang Jinghua , Zhang Yu , Si Huaijun 
Published: October 2024

AbstractAutophagy is a highly conserved method of recycling cytoplasm components in eukaryotes. It plays an important role in plant growth and development, as well as in response to biotic and abiotic stresses. Although autophagy‐related genes (ATGs) have been identified in several crop species, their particular role in potato (Solanum tuberosum L.) remains unclear. Several transcription factors and signaling genes in the transgenic lines of the model plant Arabidopsis thaliana, such as AtTSPO, AtBES1, AtPIP2;7, AtCOST1 as well as AtATI1/2, ATG8f, GFP‐ATG8F‐HA, AtDSK2, AtNBR1, AtHKT1 play crucial functions under drought and salt stresses, respectively. In this study, a total of 29 putative StATGs from 15 different ATG subfamilies in the potato genome were identified. Their physicochemical properties, evolutionary connections, chromosomal distribution, gene duplication, protein–protein interaction network, conserved motifs, gene structure, interspecific collinearity relationship, and cis‐regulatory elements were analyzed. The results of qRT‐PCR detection of StATG expression showed that 29 StATGs were differentially expressed in potato's leaves, flowers, petiole, stem, stolon, tuber, and root. StATGs were dynamically modulated by salt and drought stresses and up‐regulated under salt and drought conditions. Our results showed that the StATG8a localized in the cytoplasm and the nucleus. Potato cultivar “Atlantic” overexpressing or downregulating StATG8a were constructed. Based on physiological, biochemical, and photosynthesis parameters, potato lines overexpressing StATG8a exhibited 9 times higher drought and salt tolerance compared to non‐transgenic plants. In contrast, the potato plants with knockdown expression showed a downtrend in drought and salt tolerance compared to non‐transgenic potato lines. These results could provide new insights into the function of StATG8a in salt and drought response and its possible mechanisms.
On extensions of the Jacobson–Morozov theorem to even characteristic
Authors: Stewart David I. , Thomas Adam R. 
Published: October 2024

AbstractLet be a simple algebraic group over an algebraically closed field of characteristic 2. We consider analogues of the Jacobson–Morozov theorem in this setting. More precisely, we classify those nilpotent elements with a simple 3‐dimensional Lie overalgebra in and also those with overalgebras isomorphic to the algebras and . This leads us to calculate the dimension of the Lie automiser for all nilpotent orbits; in even characteristic this quantity is very sensitive to isogeny.