bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the immune system on the safety and efficiency of enzyme replacement therapy in lysosomal storage disorders
Authors: Broomfield A. , Jones S. A. , Hughes S. M. , Bigger B. W. 
Published: February 2016

AbstractIn the light of clinical experience in infantile onset Pompe patients, the immunological impact on the tolerability and long‐term efficacy of enzyme replacement therapy (ERT) for lysosomal storage disorders has come under renewed scrutiny. This article details the currently proposed immunological mechanisms involved in the development of anti‐drug antibodies and the current therapies used in their treatment. Given the current understanding of the adaptive immune response, it focuses particularly on T cell dependent mechanisms and the paradigm of using lymphocytic negative selection as a predictor of antibody formation. This concept originally postulated in the 1970s, stipulated that the genotypically determined lack of production or production of a variant protein determines an individual's lymphocytic repertoire. This in turn is the key factor in determining the potential severity of an individual's immunological response to ERT. It also highlights the need for immunological assay standardization particularly those looking at describing the degree of functional impact, robust biochemical or clinical endpoints and detailed patient subgroup identification if the true evaluations of impact are to be realised.
The Impaired Balance Systems Identified by the BESTest in Older Patients With Knee Osteoarthritis
Authors: Tamura Takayuki , Otaka Yohei , Konno Syunsuke , Sadashima Kento , Tomatsu Taisuke , Machida Satoshi 
Published: February 2016

AbstractBackgroundBalance decreases and activities of daily living (ADLs) deteriorate in older people with knee osteoarthritis (KOA); however, little is known about the systems underlying poor balance control and how those impaired systems are related to decreased ADL.ObjectivesTo explore which balance systems are particularly impaired and to examine the relationship between physical ADL and balance in older people with KOA.DesignCase‐control study.SettingOutpatient clinic.ParticipantsThirty people with KOA (mean age: 75.4 years) and 30 age‐matched healthy adults (mean age: 75.4 years).MethodsThe Balance Evaluation Systems Test (BESTest), consisting of 6 sections to evaluate theoretically driven balance control systems, was used for balance assessment. BESTest section scores were compared by use of the Wilcoxon rank‐sum test. Pain and physical ADL in the KOA group were evaluated with the Japanese edition of the Western Ontario and McMaster Universities Osteoarthritis Index. Spearman correlation coefficients and partial rank correlation coefficients were used to investigate the relationship between physical ADL and the BESTest scores, pain, radiography findings, and body mass index.Main Outcome MeasurementsThe BESTest total and section scores.ResultsCompared with controls, 5 of 6 BESTest section scores were significantly lower in the KOA group. Physical ADL was significantly correlated with the total BESTest score (r = −0.484, P = .007), pain (r = 0.635, P < .001), Kellgren and Lawrence grade (r = 0.601, P < .001), and body mass index (r = 0.403, P = .027). Partial rank correlation coefficients between physical ADL and the total BESTest score (r = −0.443, P = .021) or section VI‐Stability in Gait (r = −0.466, P = .014) were significant after we controlled for other variables.ConclusionsMost balance systems were impaired in older people with KOA, and this impairment was associated independently with decreased physical ADL.
Engaging firms: The global organisational field for corporate social responsibility and national varieties of capitalism
Authors: Favotto Alvise , Kollman Kelly , Bernhagen Patrick 
Published: February 2016

AbstractThis article examines the relationship between national varieties of capitalism and firm engagement with the norms and best practices promoted within the global organisational field for corporate social responsibility (CSR). Using a content analysis of the CSR reports of US and European firms, we show that firms from the coordinated market economies (CME) of Europe engage more substantively with labour and human rights than their US counterparts that operate in a liberal market economy (LME). The environmental commitments of firms in both regions, however, are more developed than practices related to these social issues. These findings support the view that CSR is more developed in CMEs than LMEs, but limit this support to social CSR issues. We posit that firms’ higher levels of engagement with environmental CSR likely reflect the extent to which environmental norms have become embedded in global markets rather than how CSR is promoted by national capitalist systems.
Co-governing common goods: Interaction patterns of private and public actors
Authors: Tosun Jale , Koos Sebastian , Shore Jennifer 
Published: February 2016

AbstractThis article addresses co-governance which can be defined as a dynamic interaction between public and private actors to secure the provision of common goods. Which types of relationship between public and private actors exist? Do the forms of co-governance change over time? When is the relationship between public and private actors cooperative, when is it competitive, and when do we witness conflictual relationships? These research questions lie at the heart of this introductory article, which seeks to shed further light on the origins and impacts of the various co-governance patterns. By reviewing the body of research on this topic, we show that different relationships between public and private actors exist, and that the forms of co-governance can also change over time. While the dominant form of co-governance is cooperation, one can also observe instances of competition or even conflict between public and private actors. Most importantly, we find that both public and private actors are ready to reclaim competences in areas where they perceive the other actor to have gained too much influence. As we discuss in this article, the degree of cooperation and competition mostly depends on the existing regulatory arrangements, the congruence of goals of the different actor groups, and the institutionalization of industrial relations. These insights help us to better understand the role co-governance can play in addressing complex public problems.
The Impossibility of a Buddhist State
Authors: SCHONTHAL Benjamin 
Published: February 2016

AbstractThis article considers the effects of special constitutional prerogatives for Buddhism in Sri Lanka. It argues that, contrary to the expectations of both supporters and opponents, these clauses have not done what they claim to do: they have not enhanced the dominance of Buddhism on the island. Through a detailed analysis of recent legal action, this article demonstrates how special constitutional protections for Buddhism, in fact, aggravate and authorize splits among Buddhists. In making this argument, this article points towards a larger thesis: constitutional provisions designed to ensure theinter-religious dominance of one tradition may, under certain circumstances, actually amplifyintra-religious conflicts over the nature, boundaries, and doctrines of that tradition. This work therefore encourages scholars to rethink the assumed polarity between secular-liberal constitutions and religiously preferential ones. Although opposed in their expressive dimensions, religiously neutral and religiously preferential constitutions may in fact generate similar church-state conundrums. The case of Sri Lanka suggests that, in the same way as perfect religious neutrality is impossible, so too is perfect religious supremacy.
INSURANCE LOSS COVERAGE UNDER RESTRICTED RISK CLASSIFICATION: THE CASE OF ISO-ELASTIC DEMAND
Authors: Hao MingJie , Macdonald Angus S. , Tapadar Pradip , Thomas R. Guy 
Published: February 2016

AbstractThis paper investigates equilibrium in an insurance market where risk classification is restricted. Insurance demand is characterised by an iso-elastic function with a single elasticity parameter. We characterise the equilibrium by three quantities: equilibrium premium; level of adverse selection (in the economist's sense); and “loss coverage”, defined as the expected population losses compensated by insurance. We consider both equal elasticities for high and low risk-groups, and then different elasticities. In the equal elasticities case, adverse selection is always higher under pooling than under risk-differentiated premiums, while loss coverage first increases and then decreases with demand elasticity. We argue that loss coverage represents the efficacy of insurance for the whole population; and therefore that if demand elasticity is sufficiently low, adverse selection is not always a bad thing.
A pharmacoeconomic study of traditional anticoagulation versus direct oral anticoagulation for the treatment of venous thromboembolism in the emergency department
Authors: Law Stephanie , Ghag Daljit , Grafstein Eric , Stenstrom Robert , Harris Devin 
Published: February 2016

AbstractObjectivesPatients with venous thromboembolism (VTE) (deep vein thrombosis [DVT] and pulmonary embolism [PE]) are commonly treated as outpatients. Traditionally, patients are anticoagulated with low-molecular-weight heparin (LMWH) and warfarin, resulting in return visits to the ED. The direct oral anticoagulant (DOAC) medications do not require therapeutic monitoring or repeat visits; however, they are more expensive. This study compared health costs, from the hospital and patient perspectives, between traditional versus DOAC therapy.MethodsA chart review of VTE cases at two tertiary, urban hospitals from January 1, 2010 to December 31, 2012 was performed to capture historical practice in VTE management, using LMWH/warfarin. This historical data were compared against data derived from clinical trials, where a DOAC was used. Cost minimization analyses comparing the two modes of anticoagulation were completed from hospital and patient perspectives.ResultsOf the 207 cases in the cohort, only 130 (63.2%) were therapeutically anticoagulated (international normalized ratio 2.0–3.0) at emergency department (ED) discharge; patients returned for a mean of 7.18 (range: 1–21) visits. Twenty-one (10%) were admitted to the hospital; 4 (1.9%) were related to VTE or anticoagulation complications. From a hospital perspective, a DOAC (in this case, rivaroxaban) had a total cost avoidance of $1,488.04 per VTE event, per patient. From a patient perspective, it would cost an additional $204.10 to $349.04 over 6 months, assuming no reimbursement.ConclusionsVTE management in the ED has opportunities for improvement. A DOAC is a viable and cost-effective strategy for VTE treatment from a hospital perspective and, depending on patient characteristics and values, may also be an appropriate and cost-effective option from a patient perspective.
Adverse Events Following Diagnostic Urethral Catheterization in the Pediatric Emergency Department
Authors: Ouellet-Pelletier Julie , Guimont Chantal , Gauthier Marie , Gravel Jocelyn 
Published: February 2016

AbstractObjectivesThe purpose of this study was to assess adverse events associated with diagnostic urethral catheterization (UC) in young children and to determine their impact on the patient and their family.MethodsThis was a prospective cohort study conducted in the emergency department of a tertiary-care pediatric hospital. All 3- to 24-month-old children with fever who had a diagnostic UC were eligible. Parents who consented to participate were contacted by phone within 7 to 10 days after the UC to answer a standardized questionnaire inquiring about complications. The primary outcome was the occurrence of an unfavourable event in the seven days following UC, defined as painful urination, genital pain, urinary retention, hematuria or secondary urinary tract infection. Secondary outcomes included the need for further medical care and the need for parents to miss school or work.ResultsOf the 199 patients who completed the study, 41 (21%) reported a complication: painful urination in 19 (10%) children, genital pain in 16 (8%), urinary retention in 11 (6%), gross hematuria in 9 (5%), and secondary urinary tract infection in 1 (0.5%). Three (1%) parents reported the need for further medical care and three (1%) missed work. Two independent variables (male sex and age 12-23 months) were associated with a higher risk of adverse events.ConclusionsUrethral catheterization is associated with adverse events in 21% of young children in the week following the procedure. Accordingly, this procedure should be used judiciously in children, considering its potential to cause unfavourable events.
Nε-(carboxymethyl)-lysine, White Matter, and Cognitive Function in Diabetes Patients
Authors: Zhang Jian-Hui , Xu Hong-Zeng , Shen Qi-Feng , Lin Yong-Zhong , Sun Chang-Kai , Sha Lin , Ge Yu-Song , Liu Ying , Wang Chun 
Published: February 2016

AbstractObjective: To study the relationship of Nε-(carboxymethyl)-lysine level (CML) with microstructure changes of white matter (WM), and cognitive impairment in patients with type 2 diabetes mellitus (T2DM) and to discuss the potential mechanism underlying T2DM-associated cognitive impairment. Methods: The study was performed in T2DM patients (n=22) with disease course ≥5 years and age ranging from 65 to 75 years old. A control group consisted of 25 sex- and age-matched healthy volunteers. Fractional anisotropy (FA) of several WM regions was analyzed by diffusion tensor imaging scan. Plasma CML levels were measured by enzyme-linked immunosorbent assay, and cognitive function was assessed by Mini-Mental State Examination and Montreal cognitive assessment (MoCA). Results: The total Mini-Mental State Examination score in the patient group (25.72±3.13) was significantly lower than the control group (28.16±2.45) (p<0.05). In addition, the total MoCA score in the patient group (22.15±3.56) was significantly lower than the control group 25.63±4.12) (p<0.01). In the patient group, FA values were significantly decreased in the corpus callosum, cingulate fasciculus, inferior fronto-occipital fasciculus, parietal WM, hippocampus, and temporal lobes relative to corresponding regions of healthy controls (p<0.05). Plasma CML level was negatively correlated with average FA values in the global brain (r=−0.58, p<0.01) and MoCA scores (r=−0.47, p<0.05). Conclusions: In T2DM, WM microstructure changes occur in older patients, and elevations in CML may play a role in the development of cognitive impairment.
High-Resolution AMS14C Dates for the Par-Tee Site (35CLT20) and Prehistoric Whale Hunting on the Oregon Coast
Authors: Sanchez Gabriel M , Erlandson Jon M , Culleton Brendan J , Kennett Douglas J , Rick Torben C 
Published: February 2016

AbstractEvidence for aboriginal whale hunting, long thought to be a practice limited to Northwest Coast tribes in northern Washington and British Columbia’s Vancouver Island, was previously reported at the Par-Tee site on the Oregon coast between about cal AD 620 and 990. An age estimate for a humpback whale phalanx with an embedded elk bone harpoon point was based on radiocarbon dates on charcoal not directly associated with the whale bone. We present high-resolution accelerator mass spectrometry (AMS)14C dates for purified bone collagen extracted directly from the whale phalanx and embedded harpoon point. A calibrated date for the harpoon point places the whale hunting event between about cal AD 430 and 550. The apparent14C age of the whale bone is estimated to be 220±3714C yr older than the marine model age at that time, consistent with values from the eastern Pacific. These new dates suggest that whale hunting took place on the Oregon coast as much as 200–500 yr earlier than previously reported and more than a millennium before historic contact in the region. Our research highlights the significance of museum collections and high-resolution AMS14C dating for addressing a variety of issues related to ancient archaeological sites and cultures.
The industrial archaeology of deep time
Authors: BULSTRODE JENNY 
Published: February 2016

AbstractFor geologists and antiquaries of the late 1850s debates over ancient stone tools were frustrated by a lack of accepted criteria. The artefacts were hard to interpret. It was not self-evident how to judge whether they were ancient or modern, natural or man-made; or indeed whether stone tools could pre-date the use of metal tools at all. Antiquary and papermaker John Evans provided a system that offered to resolve these issues. His criteria and his use of re-enactment, making his own stone implements, gained acceptance among flint experts across fluid disciplinary boundaries and enabled authoritative interpretations of the underdetermined objects. This paper explores how Evans drew on the concerns of his industrial culture to make sense of prehistoric artefacts and support his claim to access the past through his own actions. Situated industrial concerns provided the resources for his flint work: from a patent dispute with astronomer and fellow industrialist Warren de la Rue, through his role in the Victorian arms trade, to the struggle to displace skilled manual labour in his factories. Evans is remembered for pioneering the techniques and classificatory system of modern Palaeolithic archaeology and as one of the founders of the re-enactment science of experimental flint knapping. His work played a significant role in helping reconceive the antiquity of man, yet the system of proof for this grand claim was deeply situated in his industrial culture. This paper explores how the industrial resources of a Victorian papermaker made human history.
Improved interpretation of studies comparing methods of dietary assessment: combining equivalence testing with the limits of agreement
Authors: Batterham Marijka J. , Van Loo Christel , Charlton Karen E. , Cliff Dylan P. , Okely Anthony D. 
Published: February 2016

AbstractThe aim of this study was to demonstrate the use of testing for equivalence in combination with the Bland and Altman method when assessing agreement between two dietary methods. A sample data set, with eighty subjects simulated from previously published studies, was used to compare a FFQ with three 24 h recalls (24HR) for assessing dietary I intake. The mean I intake using the FFQ was 126·51 (sd 54·06) µg and using the three 24HR was 124·23 (sd 48·62) µg. The bias was −2·28 (sd 43·93) µg with a 90 % CI 10·46, 5·89 µg. The limits of agreement (LOA) were −88·38, 83·82 µg. Four equivalence regions were compared. Using the conventional 10 % equivalence range, the methods are shown to be equivalent both by using the CI (−12·4, 12·4 µg) and the two one-sided tests approach (lower t=−2·99 (79 df), P=0·002; upper t=2·06 (79 df), P=0·021). However, we make a case that clinical decision making should be used to set the equivalence limits, and for nutrients where there are potential issues with deficiency or toxicity stricter criteria may be needed. If the equivalence region is lowered to ±5 µg, or ±10 µg, these methods are no longer equivalent, and if a wider limit of ±15 µg is accepted they are again equivalent. Using equivalence testing, acceptable agreement must be assessed a priori and justified; this makes the process of defining agreement more transparent and results easier to interpret than relying on the LOA alone.
Gastrointestinal modifications and bioavailability of brown seaweed phlorotannins and effects on inflammatory markers
Authors: Corona Giulia , Ji Yang , Anegboonlap Prapaporn , Hotchkiss Sarah , Gill Chris , Yaqoob Parveen , Spencer Jeremy P. E. , Rowland Ian 
Published: February 2016

AbstractBrown seaweeds such asAscophyllum nodosumare a rich source of phlorotannins (oligomers and polymers of phloroglucinol units), a class of polyphenols that are unique to Phaeophyceae. At present, there is no information on the bioavailability of seaweed polyphenols and limited evidence on their bioactivityin vivo. Consequently, we investigated the gastrointestinal modificationsin vitroof seaweed phlorotannins fromA. nodosumand their bioavailability and effect on inflammatory markers in healthy participants.In vitro, some phlorotannin oligomers were identified after digestion and colonic fermentation. In addition, seven metabolites corresponding toin vitro-absorbed metabolites were identified. Urine and plasma samples contained a variety of metabolites attributed to both unconjugated and conjugated metabolites (glucuronides and/or sulphates). In both urine and plasma, the majority of the metabolites were found in samples collected at late time points (6–24 h), suggesting colonic metabolism of high-molecular-weight phlorotannins, with three phlorotannin oligomers (hydroxytrifuhalol A, 7-hydroxyeckol, C-O-C dimer of phloroglucinol) identified in urine samples. A significant increase of the cytokine IL-8 was also observed. Our study shows for the first time that seaweed phlorotannins are metabolised and absorbed, predominantly in the large intestine, and there is a large inter-individual variation in their metabolic profile. Three phlorotannin oligomers present in the capsule are excreted in urine. Our study is the first investigation of the metabolism and bioavailability of seaweed phlorotannins and the role of colonic biotransformation. In addition, IL-8 is a possible target for phlorotannin bioactivity.
A brief analysis of countries’ patterns of participation in the Antarctic Treaty Consultative Meetings (1998–2011); towards leveling the playing field?
Authors: Sánchez Rodolfo A. 
Published: February 2016

ABSTRACTThis paper attempts to describe Consultative Parties’ (CPs) patterns of participation at the Antarctic Treaty Consultative Meetings (ATCM) during the 1998–2011 period. The results of this work show that a subset of the original signatories of the Antarctic Treaty exert the greatest political influence on ATCMs, and can therefore be seen as the main ‘propellers’ of the ATCM system. Although the performance of some of the non-original signatories is becoming increasingly consistent, the system still offers the appearance of being rather asymmetric and endogamic. In addition, a number of factors that might explain the patterns of participation observed are presented and discussed, as a contribution that may allow for achieving a more comprehensive picture of how the work of the ATCMs unfolds through time. The article concludes by presenting likely directions towards which future research on behavioural aspects of Antarctic policy making can be orientated.
Molecular mechanisms of xeroderma pigmentosum (XP) proteins
Authors: Koch Sandra C. , Simon Nina , Ebert Charlotte , Carell Thomas 
Published: February 2016

AbstractNucleotide excision repair (NER) is a highly versatile and efficient DNA repair process, which is responsible for the removal of a large number of structurally diverse DNA lesions. Its extreme broad substrate specificity ranges from DNA damages formed upon exposure to ultraviolet radiation to numerous bulky DNA adducts induced by mutagenic environmental chemicals and cytotoxic drugs used in chemotherapy. Defective NER leads to serious diseases, such as xeroderma pigmentosum (XP). Eight XP complementation groups are known of which seven (XPA–XPG) are caused by mutations in genes involved in the NER process. The eighth gene, XPV, codes for the DNA polymeraseɳ, which replicates through DNA lesions in a process called translesion synthesis (TLS). Over the past decade, detailed structural information of these DNA repair proteins involved in eukaryotic NER and TLS have emerged. These structures allow us now to understand the molecular mechanism of the NER and TLS processes in quite some detail and we have begun to understand the broad substrate specificity of NER. In this review, we aim to highlight recent advances in the process of damage recognition and repair as well as damage tolerance by the XP proteins.