bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improved osteogenesis and upregulated immunogenicity in human placenta-derived mesenchymal stem cells primed with osteogenic induction medium
Authors: Fu Xuejie , Yang Huilin , Zhang Hui , Wang Guichao , Liu Ke , Gu Qiaoli , Tao Yunxia , Chen Guangcun , Jiang Xiaohua , Li Gang , Gu Yanzheng , Shi Qin 
Published: September 2016

Abstract
Background
Mesenchymal stem cells (MSCs) are widely used in cell-based therapy owing to their multilineage potential and low immunogenicity. However, low differentiation efficiency and unpredictable immunogenicity of allogeneic MSCs in vivo limit their success in therapeutic treatment. Herein, we evaluated the differentiation potential and immunogenicity of human placenta-derived MSCs manipulated with osteogenic priming and dedifferentiation process.

Methods
MSCs from human placentas were subjected to osteogenic induction and then cultivated in osteogenic factor-free media; the obtained cell population was termed dedifferentiated mesenchymal stem cells (De-MSCs). De-MSCs were induced into osteo-, chondro- and adipo-differentiation in vitro. Cell proliferation was quantified by a Cell-Counting Kit-8 or tritiated thymidine ([3H]-TdR) incorporation. Meanwhile, the osteogenesis of De-MSCs in vivo was assayed by real-time PCR and histological staining. The expressions of stem cell markers and co-stimulatory molecules on De-MSCs and lymphocytes from primed BALB/c mouse with De-MSCs were determined by flow cytometry.

Results
De-MSCs exhibited some properties similar to MSCs including multiple differentiation potential and hypoimmunogenicity. Upon re-osteogenic induction, De-MSCs exhibited higher differentiation capability than MSCs both in vitro and in vivo. Of note, De-MSCs had upregulated immunogenicity in association with their osteogenesis, reflected by the alternated expressions of co-stimulatory molecules on the surface and decreased suppression on T cell activation. Functionally, De-MSC-derived osteoblasts could prime lymphocytes of peripheral blood and spleen in BALB/c mice in vivo.

Conclusions
These data are of great significance for the potential application of De-MSCs as an alternative resource for regenerative medicine and tissue engineering. In order to avoid being rejected by the host during allogeneic De-MSC therapy, we suggest that immune intervention should be considered to boost the immune acceptance and integration because of the upregulated immunogenicity of De-MSCs with redifferentiation in clinical applications.
Vasectomy and Prostate Cancer Incidence and Mortality in a Large US Cohort
Authors: Jacobs Eric J. , Anderson Rebecca L. , Stevens Victoria L. , Newton Christina C. , Gansler Ted , Gapstur Susan M. 
Published: September 2016

Purpose In a recent large prospective study, vasectomy was associated with modestly higher risk of prostate cancer, especially high-grade and lethal prostate cancer. However, evidence from prospective studies remains limited. Therefore, we assessed the associations of vasectomy with prostate cancer incidence and mortality in a large cohort in the United States. Patients and Methods We examined the association between vasectomy and prostate cancer mortality among 363,726 men in the Cancer Prevention Study II (CPS-II) cohort, of whom 7,451 died as a result of prostate cancer during follow-up from 1982 to 2012. We also examined the association between vasectomy and prostate cancer incidence among 66,542 men in the CPS-II Nutrition Cohort, a subgroup of the CPS-II cohort, of whom 9,133 were diagnosed with prostate cancer during follow-up from 1992 to 2011. Cox proportional hazards regression modeling was used to estimate multivariable-adjusted hazard ratios (HRs) and 95% CIs. Results In the CPS-II cohort, vasectomy was not associated with prostate cancer mortality (HR, 1.01; 95% CI, 0.93 to 1.10). In the CPS-II Nutrition Cohort, vasectomy was not associated with either overall prostate cancer incidence (HR, 1.02; 95% CI, 0.96 to 1.08) or high-grade prostate cancer incidence (HR, 0.91; 95% CI, 0.78 to 1.07 for cancers with Gleason score ≥ 8). Conclusion Results from these large prospective cohorts do not support associations of vasectomy with either prostate cancer incidence or prostate cancer mortality.
Aldosterone-Producing Adenoma With a Somatic KCNJ5 Mutation Revealing APC-Dependent Familial Adenomatous Polyposis
Authors: Vouillarmet Julien , Fernandes-Rosa Fabio , Graeppi-Dulac Julia , Lantelme Pierre , Decaussin-Petrucci Myriam , Thivolet Charles , Peix Jean-Louis , Boulkroun Sheerazed , Clauser Eric , Zennaro Maria-Christina 
Published: September 2016

Context:Recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 have been identified in aldosterone-producing adenomas (APAs). The question as to whether they are responsible for both nodulation and aldosterone production is not solved.Case Description:We describe the case of a young patient who was diagnosed with severe arterial hypertension due to primary aldosteronism at age 26 years, followed by hemorrhagic stroke 4 years later. Abdominal computed tomography showed bilateral macronodular adrenal hyperplasia. Identification of lateralized aldosterone secretion led to right adrenalectomy, followed by normalization of biochemical and hormonal parameters and amelioration of blood pressure. The resected adrenal showed three nodules, one of them expressing aldosterone synthase and harboring a somatic KNCJ5 mutation. A Weiss revisited index of 3 of the APA prompted us to perform a second 18F-2-fluoro-2-deoxy-D-glucose-positron emission tomography after surgery, which revealed abnormal rectal activity despite the absence of clinical symptoms. Gastrointestinal exploration showed multiple polyps with severe dysplasia, and the diagnosis of familial adenomatous polyposis was established in the presence of a germline heterozygous APC gene mutation. Sequencing of somatic DNA from the APA and a second adrenal nodule revealed biallelic APC inactivation due to loss of heterozygosity in both nodules.Conclusions:This case report underlines the need for establishing the frequency of germline APC variants in patients with primary aldosteronism and bilateral macronodular adrenal hyperplasia because their presence may predispose to APA development and severe hypertension well before the first familial adenomatous polyposis symptoms appear. From a mechanistic point of view, it supports a two-hit model for APA development, whereby the first hit drives increased cell proliferation whereas the second hit specifies the pattern of hormonal secretion.
Items of jewelry art of pre- Mongolian Russia in the collections of Russian museums
Authors: Макаренко Зоя , Makarenko Zoya , Жилкова Юлия , Zhilkova Yuliya , Бережная Марина , Berezhnaya Marina 
Published: September 2016

The article deals with the question of exhibiting of jewelry art items of pre-Mongolian Russia in Russian museums. Public and private museums that were opening in the Russian Empire contributed to preservation of the cultural heritage of the country. When they were emerging, many private collectors donated part or all of their collections to state. This was especially promoted by opening of the Historical Museum in 1883 for the general public. Exhibits of public museum were replenished by the collections of Uvarovs, Kropotkins, Shcherbatovs, Golitsyns. The fate of collection of the outstanding collector M. Botkin is noteworthy.
Masterpieces of jewelry art of ancient Russia may be exhibited in only a few museums in the country, including two sites in the Moscow Kremlin, which show such kind of items. Collection &#34;Russian gold and silverware of beginning of XII-XVII centuries&#34; is located in the exposition hall 1 of Armory Chamber. The glass case 2 presents gold and silver items, made by goldsmiths of Kiev, Chernigov, Ryazan, Suzdal, Novgorod.
Museum affair after the October Revolution in the country was significantly reformed. Museums and collections of the palaces were declared as the national property. For registration, accounting and secure of all artistic and cultural treasures, the artistic and historical commissions and the State Museum Fund were created. Majority private collections were nationalized.
Russian Museum, located in the Mikhailovsky Palace in Sankt Petersburg has one of the largest collections of pre-Mongolian Russian treasures and individual items of jewelry art of X-XIII centuries.
Thousands of works of jewelry art of ancient Russia are collected in the expositions and funds of Russian museums. Today collections of not only central but also local museums are multiplied, facilities and exhibitions are quality improving.
Providing advice to travellers with diabetes
Authors: Phillips Anne , Carling Janet 
Published: September 2016

The number of people travelling with diabetes has increased in recent years. Anne Phillips and Janet Carling highlight the importance of pre-travel advice to reduce the risk of problems occuring for travellers It is important for people with diabetes who plan to travel to receive appropriate advice to make the trip as safe as possible. The information the person with diabetes receives should be individualised and tailored to their particular needs. It is critical for the the individual to achieve good blood glucose control before travelling to avoid the risk of complications while abroad, and they should also receive the country-specific travel advice for vaccinations that other travellers would receive. Diabetes does not prevent travel, but requires careful planning by both the health professional and the traveller.
Distal biceps tendon injuries
Authors: Alentorn-Geli Eduard , Assenmacher Andrew T. , Sánchez-Sotelo Joaquín 
Published: September 2016

Distal biceps tendon (DBT) conditions comprise a spectrum of disorders including bicipitoradial bursitis, partial tears, acute and chronic complete tears. In low-demand patients with complete DBT tears, non-operative treatment may be entertained provided the patient understands the potential for residual weakness, particularly in forearm supination. Most acute tears are best treated by primary repair using either single-incision or double-incision techniques with good clinical outcomes. Single-incision techniques may carry a higher risk of nerve-related complications, whereas double-incision techniques have historically been considered to carry a higher risk of heterotopic ossification, particularly if the ulna is exposed. Various fixation techniques, including bone tunnels, cortical buttons, suture anchors, interference screws or a combination seem to provide different fixation strength but similar clinical outcomes. Some chronic tears may be repaired primarily, provided tendon tissue can be identified; alternatively, autograft or allograft reconstruction can be considered, and good outcomes have been reported with both techniques. Cite this article: Alentorn-Geli E, Assenmacher AT, Sanchez-Sotelo J. Distal biceps tendon injuries: a clinically relevant current concepts review. EFORT Open Rev 2016;1:316-324. DOI: 10.1302/2058-5241.1.000053.
Prescribing Errors with Levetiracetam Oral Solution/Communicate Insulin Dose and Concentration on Separate/Lines Risperidone and Ropinirole Mix-ups/IV Line Disinfection Caps Can Become Foreign Bodies
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: September 2016

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers' names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters' wishes as to the level of detail included in publications.
Impact of a Pharmacy-Led Pain Management Team on Adults in an Academic Medical Center
Authors: Mathew Stacy , Chamberlain Carol , Alvarez Kristin S. , Alvarez Carlos A. , Shah Monal 
Published: September 2016

Background Pain is a major health problem affecting more than 15% of adults in the United States. In a multidisciplinary pain management team, pharmacists can optimize pharmacotherapy quality by ensuring safe and appropriate medication use. Objective Assess the impact of a pharmacy pain medication management service on pain-related outcomes in an adult inpatient population. Methods This retrospective study evaluated patients who were admitted from November 2009 through November 2011 and received a pharmacy pain consult. Patients were excluded if they left against medical advice, their care was assumed by palliative care, or they had no complaint of pain when seen by the pharmacist. The primary outcome was the difference between each patient's average pain score from pre-consult to post-consult. Secondary outcomes were difference between each patient's average pain score from pre-consult to pre-discharge, overall functional improvement, pharmacist interventions, and 14-day and 30-day readmissions. Results One hundred patients were included in the final analysis. Eight hundred twenty-one interventions were made by the clinical pharmacists. Patients displayed a significant reduction in their pre- and post-consult pain intensity scores on a 0 to 10 numerical rating scale (6.15 vs 3.25; p < .001). Likewise, a significant reduction in pain intensity scores was seen from pre-consult to pre-discharge (6.15 vs 3.6; p < .001). Overall functional improvement, specifically sleep, mobility, and appetite, was seen in 86.6% of patients. Conclusions Pain management is an area that provides opportunities for pharmacotherapy interventions. Pharmacists' involvement in pain management on an inpatient consult service had a positive impact on pain scores and improvement in functionality.
The therapeutic agents that target ATP-sensitive potassium channels
Authors: Rubaiy Hussein N. 
Published: September 2016

Abstract
ATP-sensitive potassium (KATP) channels are a major drug target for the treatment of type-2 diabetes. KATP channels are ubiquitously expressed and link the metabolic state to electrical excitability. In pancreatic β-cells, KATP channels are crucial in the regulation of glucose-induced insulin secretion. Also, KATP channels are involved in the protection against neuronal seizures and ischaemic stress in the heart, brain and in the regulation of vascular smooth muscle tone. Functional KATP channels are hetero-octamers composed of two subunits, a pore forming Kir6, which is a member of the inwardly rectifying potassium channels family, and a regulatory sulphonylurea receptor (SUR). In response to nucleotides and pharmaceutical agonists and antagonists, SUR allosterically regulates channel gating. The allosteric communication pathways between these two heterologus proteins in KATP channels are still poorly understood. This review will highlight the therapeutic agents that target KATP channels and are used to treat diabetes and cardiovascular diseases.
Decay of solutions to a fourth-order nonlinear Schrödinger equation
Authors: Saanouni Tarek 
Published: September 2016

Abstract
Let

u
∈

C
⁢

(
ℝ
,

H
2

)

${u\in C(\mathbb{R},H^{2})}$

be the solution to the initial value problem for a fourth-order semi-linear Schrödinger equation with pure power nonlinearity. We prove that some

L
r

${L^{r}}$

-norms
of u decay as

t
→

±
∞

${t\to\pm\infty}$

.
Are Invisible Hands Good Hands in Health Care Markets? Extension
Authors: Wang Hao 
Published: September 2016

AbstractA previous study finds that increased competition in health care markets improves social welfare, although consumers use “too much” health care when they have health insurance. The analysis assumes that consumers have a constant Arrow-Pratt coefficient of absolute risk aversion. This note shows that this finding can be extended to the case where consumers are simply risk averse. Furthermore, if insurers offered insurance policies with slightly lower usage prices than the equilibrium level, social welfare would be improved.
Occurrence of Talavera aperta (Miller, 1971) (Araneae: Salticidae) in Poland
Authors: Rozwałka Robert , Rutkowski Tomasz , Sienkiewicz Paweł , Renn Katarzyna 
Published: September 2016

Abstract
Talavera aperta is a rare member of the Salticidae (jumping spiders). Its presence in Poland has been questioned. This paper presents data on 20 new localities of this poorly known species and a map of its distribution in western and central Poland. Detailed drawings of the male body, male palps and the female epigynum are also provided. T. aperta was usually collected from dry, sunny habitats, mostly in June, although some specimens were recorded in other months. In winter, spiders of this species were found in shells of small snails (Cepaea spp., Helicella obvia).
Protein pattern of canola (Brassica napus L.) changes in response to salt and salicylic acid in vitro
Authors: Razavizadeh Roya 
Published: September 2016

Abstract
The effect of salicylic acid (SA) on the salt (NaCl) tolerance mechanism was studied in canola plants (oilseed rape, Brassica napus L.) by molecular and physiological experiments in plant tissue culture. Seeds of B. napus ‘Ocapy’ were germinated at 0, 50, and 100 mM NaCl on Murashige and Skoog (MS) medium containing different levels (0, 2, and 5 μM) of SA for 4 weeks. Total chlorophyll, carotenoid, and flavonoid content increased in response to interactive effects of SA and NaCl treatments at some concentrations. Proline content was increased under salt and SA treatments in shoot and root tissues. Salt alone and in combination with SA increased the total soluble protein content of shoots only, while the different concentrations of SA in the culture media affected variously the total soluble protein content. Protein patterns of shoots and roots showed some remarkable differences, based on gel electrophoresis and the consequent analysis of bands by ImageJ program. The relative expression of 15 and 12 protein bands in shoots and roots, respectively, differed under the applied treatments. In addition, the protein profile indicated that salinity and SA regulate the expression of salt-stress-inducible proteins as well as induced de novo synthesis of specific polypeptides. The findings may help to explain the salt tolerance mechanisms and to produce salt-tolerant canola plants.
Jurassic animals and algae in the flooring of Our Lady of Sorrows Church in Poznań
Authors: Antczak Mateusz 
Published: September 2016

Abstract
The flooring of Our Lady of Sorrows Church in Poznań is made of Jurassic rocks from the Świętokrzyskie Mountains (also known as Holy Cross Mountains) and contain abundant marine invertebrate fossils: sponges, bivalves, brachiopods, various families of cephalopods, etc. Some of them can be identified to the genus level. The fossils make it possible to describe the environment and ecosystem of the Jurassic sea and biostratigraphy of the sediment. There are also some significant inorganic structures, which suggest post-diagenetic tectonic movements.
Fecal calprotectin in inflammatory bowel diseases: update and perspectives
Authors: Manceau Hana , Chicha-Cattoir Valérie , Puy Hervé , Peoc’h Katell 
Published: September 2016

AbstractInflammatory bowel diseases (IBDs) are chronic diseases that result from the inflammation of the intestinal wall, suspected in any patient presenting with intestinal symptoms. Until recently, the diagnosis was mainly based on both clinical and endoscopic arguments. The use of an easy, fast, reliable, non-invasive, and inexpensive biological assay is mandatory not only in diagnosis but also in evolutionary and therapeutic monitoring. To date, the fecal calprotectin is the most documented in this perspective. This marker allows the discrimination between functional and organic bowel processes with good performance. The determination of the fecal calprotectin level contributes to the evaluation of the degree of disease activity and to monitoring of therapeutic response.
The EU’s Maritime Security Strategy: a Neo-Medieval Perspective on the Limits of Soft Security?
Authors: Flynn Brendan 
Published: September 2016

Abstract
This paper offers a critical interpretation of the EU’s recent Maritime Security Strategy (MSS) of 2014, making distinctions between hard and soft conceptions of maritime security. The theoretical approach employed invokes the ‘EU as neo-medieval empire’ (Bull 1977: 254-255; Rennger 2006; Zielonka 2006). By this account, the main objectives of EU maritime strategy are stability and encouragement of globalised maritime trade flows to be achieved using the classic instruments of ‘soft maritime security’. While replete with great possibilities, the EU’s maritime security strategy is likely to be a relatively weak maritime security regime, which suffers from a number of important limits.
There are genus one curves of every index over every infinite, finitely generated field
Authors: Clark Pete L. , Lacy Allan 
Published: September 2016

Abstract
We show that a nontrivial abelian variety over a Hilbertian field in which the weak Mordell–Weil theorem holds admits infinitely many torsors with period any given

n
>
1

n>1

that is not divisible by the characteristic. The corresponding statement with “period” replaced by “index” is plausible but open, and it seems much more challenging. We show that for every infinite, finitely generated field K, there is an elliptic curve

E

/
K

E_{/K}

which admits infinitely many torsors with index any given

n
>
1

n>1

.
Representations of categories of G-maps
Authors: Sam Steven V , Snowden Andrew 
Published: September 2016

Abstract
We study representations of wreath product analogues of categories of finite sets. This includes the category of finite sets and injections (studied by Church, Ellenberg, and Farb) and the opposite of the category of finite sets and surjections (studied by the authors in previous work). We prove noetherian properties for the injective version when the group in question is polycyclic-by-finite and use it to deduce general twisted homological stability results for such wreath products and indicate some applications to representation stability. We introduce a new class of formal languages (quasi-ordered languages) and use them to deduce strong rationality properties of Hilbert series of representations for the surjective version when the group is finite.