bluuebunny/crossref_metadata_2025_split huggingface dataset:
APOE, MAPT, and COMT and Parkinson’s Disease Susceptibility and Cognitive Symptom Progression
Authors: Paul Kimberly C. , Rausch Rebecca , Creek Michelle M. , Sinsheimer Janet S. , Bronstein Jeff M. , Bordelon Yvette , Ritz Beate 
Published: May 2016

Background: Cognitive decline is well recognized in Parkinson’s disease (PD) and a major concern for patients and caregivers. Apolipoprotein E ( APOE), catechol-O-methyl transferase ( COMT), and microtubule-associated protein tau ( MAPT) are of interest related to their contributions to cognitive decline or dementia in PD. Objective: Here, we investigate whether APOE, COMT, or MAPT influence the rate of cognitive decline in PD patients. Methods: We relied on 634 PD patients and 879 controls to examine gene-PD susceptibility associations, and nested longitudinal cohort of 246 patients from the case-control study, which followed patients on average 5 years and 7.5 years into disease. We repeatedly assessed cognitive symptom progression with the MMSE and conducted a full neuropsychological battery on a subset of 183 cognitively normal patients. We used repeated-measures regression analyses to assess longitudinal associations between genotypes and cognitive progression scores. Results: The MAPT H1 haplotype was associated with PD susceptibility. APOE 4 carriers ( ɛ4+) ( p = 0.03) and possibly COMT Met/Met ( p = 0.06) carriers exhibited faster annual decline on the MMSE. Additionally, APOE ɛ4+ carriers showed faster decline in many of the neuropsychological test scores. No such differences in neuropsychological outcomes were seen for the COMT genotypes. Conclusion: This work supports a growing set of research identifying overlapping etiology and pathology between synucleinopathies, such as PD, Alzheimer’s disease, and tauopathies, especially in the context of cognitive dysfunction in PD. We provide support for the argument that APOE ɛ4+ and COMT Met/Met genotypes can be used as predictors of faster cognitive decline in PD.
Development and Validation of the Parkinson’s Disease Medication Beliefs Scale (PD-Rx)
Authors: Fleisher Jori E. , Dahodwala Nabila A. , Xie Sharon X. , Mayo Mark , Weintraub Daniel , Chodosh Joshua , Shea Judy A. 
Published: May 2016

Background: Medication non-adherence is common in Parkinson’s disease (PD) and is associated with increased disability and healthcare costs. Individuals’ beliefs regarding their medical conditions and treatments impact medication adherence. While instruments exist to measure patients’ beliefs about medications in general, no such tool exists for PD. Objectives: Create an instrument eliciting medication beliefs of persons with PD; identify demographic and clinical characteristics associated with beliefs; and examine whether beliefs are associated with dopaminergic therapy adherence. Methods: We developed the Parkinson’s Disease Medication Beliefs Scale (PD-Rx) in four phases: focus groups of patients and caregivers to generate items, scale development, expert and patient revision of items, and a cross-sectional validation sample ( n = 75). Adherence was calculated using two approaches incorporating self-reported medication lists. Results: The PD-Rx consists of 11 items covering benefits and risks of PD pharmacotherapies. The scale covers motor improvement, current adverse effects, and future concerns. Higher scores indicate more positive beliefs. Internal consistency was acceptable (Cronbach’s alpha = 0.67). Test-retest reliability was 0.47. Quality of life was associated with PD-Rx scores, and lower scores were associated with non-adherence. Conclusions: Negative beliefs about PD treatments are associated with lower quality of life and may be related to medication non-adherence. Further study of any causal relationship between beliefs and medication non-adherence in PD will inform the design of future patient-centered interventions to improve adherence.
Reduction of Small Fibers of Thoracic Ventral Roots and Neurons of Intermediolateral Nucleus in Parkinson Disease and Dementia with Lewy Bodies
Authors: Hatsuta Hiroyuki , Takao Masaki , Nakano Yuta , Nogami Akane , Uchino Akiko , Sumikura Hiroyuki , Kanemaru Kazutomi , Arai Tomio , Itoh Yoshiaki , Murayama Shigeo 
Published: May 2016

Background and objective: Loss of intermediolateral nucleus (IML) neurons is considered to play a major role in orthostatic hypotension (OH) of multiple system atrophy (MSA). In Parkinson disease (PD) and dementia with Lewy bodies (DLB), autonomic phenomena such as OH are common and attributed to dysfunction of sympathetic, parasympathetic, and visceral autonomic neurons. However, apart from MSA, few reports have focused on the neuropathologic aspects in PD and DLB. Here we assessed IML degeneration as well as the fine myelinated fibers (FFs; maximum diameter less than 3 μm) considered to be preganglionic sympathetic nerve fibers derived from IML neurons in PD, DLB, MSA, and age-matched normal controls (NC). Methods: We counted IML neurons and measured the diameter and number of myelinated fibers of the ventral root at the level of the 12th thoracic segment. Results: Compared to NC, number of IML neurons and density of FF were significantly reduced in PD (53% and 67%), DLB (47% and 71%) and MSA (27% and 42%). Compared to combined group of PD and DLB without OH (OH–), IML neurons in combined group of PD and DLB with OH (OH+) were significantly reduced (77%). Compared to NC, FF densities in OH–, OH+ were significantly reduced (74% and 59%). The mean ratio of small to large myelinated fibers in OH+ (1.18), but not that in OH–(1.58), was significantly lower than that in NC (3.17). Conclusions: We present neuropathological evidence that IML neurons and FFs in the ventral root are reduced in PD and DLB and that the reduction was more severe in the combined group of OH+ than in OH–.
A new framework for RFID use cases in fashion and apparel retailing
Authors: Rizzi A. , Romagnoli G. , Thiesse F. 
Published: May 2016

OBJECTIVE: This paper aims at proposing a new framework for the classification of RFID deployments in fashion and apparel retailing. The framework encompasses several different use cases (UCs) pursued by fashion and apparel retailers in the last decade, and updates, expands and goes beyond what has already been presented in the related literature. DESIGN, METHODOLOGY, APPROACH: We carried out a comprehensive literature review on RFID deployments in fashion and apparel retail. We searched different sources of information, that is, scientific papers, conferences and seminars proceedings, websites, magazines, newspapers etc., up to 160 papers that were carefully analysed and organised in a structured database. This data set also comprehends information from confidential projects. We analyse contents on the level of single RFID projects, that is, feasibility studies, proofs of concept, pilots or deployments. For each project, we determine what specific UCs were at stake. Eventually, the framework of all possible RFID UCs emerged from the analysis, and we set up a panel of industry partners to validate the framework using the Delphi method. FINDINGS: We structured the new framework along two levels: first, 6 categories were identified (i.e., level 1 use cases). Each category was then detailed, resulting in a total of 18 specific UCs (i.e., level 2 use cases). Each level 2 UC corresponds to a very specific objective pursued by an RFID implementation. For each UC, we propose a set of business metrics to evaluate deployment success as well as benefits achieved. PRACTICAL IMPLICATIONS: From a practitioner’s perspective, the framework offers a comprehensive and well-structured overview of the cost- and the revenue-related potentials of RFID implementations in the industry. Researchers, on the other hand, may use the framework to identify opportunities for further research regarding RFID deployments in retailing. ORIGINALITY/VALUE: Our framework is based on the current body of literature, and complements prior studies, which served as the starting point for our research.
Analysis of time variant reliability information used in a multilevel decoding scheme for RFID and sensor signals
Authors: Jacobi Rebekka Carmen , vom Bögel Gerd , Grabmaier Anton , Kolossa Dorothea 
Published: May 2016

In medicine and other high-tech sectors, mobile RFID or sensor transponder systems are designed with high-Q antenna coils to increase the energy efficiency. Hence, the range of inductively coupled systems is improved; however, the bandwidth is decreased by 1 over Q. As a result, the reading performance is not limited by the energy supply, but instead by a high bit error rate. In this paper, we describe how the data detection in such narrow-band systems can be improved by a multilevel decoding scheme composed of an advanced maximum-likelihood receiver in the ?rst stage and a soft Viterbi decoding scheme utilizing time variant reliability information in the second stage. An analysis of potential time-variant reliability information is given. The analysis relies on an underlying Bayesian model, which provides an a-posteriori probability indicating the reliability of the received input. As the final building block, a last decoding stage is discussed, which can be composed of a forward error correction that further exploits the reliability information at the second decoder output. Overall, the suggested system architecture results in a notable improvement of both bit and packet error rate, thus allowing the use of high-quality-factor antennas for efficient and reliable mobile RFID systems.
State of the science on prevention and screening to reduce melanoma incidence and mortality: The time is now
Authors: Tripp Mary K. , Watson Meg , Balk Sophie J. , Swetter Susan M. , Gershenwald Jeffrey E. 
Published: May 2016

ABSTRACTAnswer questions and earn CME/CNEAlthough overall cancer incidence rates are decreasing, melanoma incidence rates continue to increase about 3% annually. Melanoma is a significant public health problem that exacts a substantial financial burden. Years of potential life lost from melanoma deaths contribute to the social, economic, and human toll of this disease. However, most cases are potentially preventable. Research has clearly established that exposure to ultraviolet radiation increases melanoma risk. Unprecedented antitumor activity and evolving survival benefit from novel targeted therapies and immunotherapies are now available for patients with unresectable and/or metastatic melanoma. Still, prevention (minimizing sun exposure that may result in tanned or sunburned skin and avoiding indoor tanning) and early detection (identifying lesions before they become invasive or at an earlier stage) have significant potential to reduce melanoma incidence and melanoma‐associated deaths. This article reviews the state of the science on prevention and early detection of melanoma and current areas of scientific uncertainty and ongoing debate. The US Surgeon General's Call to Action to Prevent Skin Cancer and US Preventive Services Task Force reviews on skin cancer have propelled a national discussion on melanoma prevention and screening that makes this an extraordinary and exciting time for diverse disciplines in multiple sectors—health care, government, education, business, advocacy, and community—to coordinate efforts and leverage existing knowledge to make major strides in reducing the public health burden of melanoma in the United States. CA Cancer J Clin 2016;66:460–480. © 2016 American Cancer Society.
SECOND EPOCH VLBA CALIBRATOR SURVEY OBSERVATIONS: VCS-II
Authors: Gordon David , Jacobs Christopher , Beasley Anthony , Peck Alison , Gaume Ralph , Charlot Patrick , Fey Alan , Ma Chopo , Titov Oleg , Boboltz David 
Published: May 2016

ABSTRACT
Six very successful Very Long Baseline Array (VLBA) calibrator survey campaigns were run between 1994 and 2007 to build up a large list of compact radio sources with positions precise enough for use as very long baseline interferometry (VLBI) phase reference calibrators. We report on the results of a second epoch VLBA Calibrator Survey campaign (VCS-II) in which 2400 VCS sources were re-observed in the X and S bands in order to improve the upcoming third realization of the International Celestial Reference Frame (ICRF3) as well as to improve their usefulness as VLBI phase reference calibrators. In this survey, some 2062 previously detected sources and 324 previously undetected sources were detected and revised positions are presented. Average position uncertainties for the re-observed sources were reduced from 1.14 and 1.98 mas to 0.24 and 0.41 mas in R.A. and decl., respectively, or by nearly a factor of 5. Minimum detected flux values were approximately 15 and 28 mJy in the X and S bands, respectively, and median total fluxes are approximately 230 and 280 mJy. The vast majority of these sources are flat-spectrum sources, with ∼82% having spectral indices greater than −0.5.
THE COMPOSITE SPECTRUM OF BOSS QUASARS SELECTED FOR STUDIES OF THE Lyα FOREST
Authors: Harris David W. , Jensen Trey W. , Suzuki Nao , Bautista Julian E. , Dawson Kyle S. , Vivek M. , Brownstein Joel R. , Ge Jian , Hamann Fred , Herbst H. , Jiang Linhua , Moran Sarah E. , Myers Adam D. , Olmstead Matthew D. , Schneider Donald P. 
Published: May 2016

ABSTRACT
The Baryon Oscillation Spectroscopic Survey (BOSS) has collected more than 150,000 2.1 ≤ z ≤ 3.5 quasar spectra since 2009. Using this unprecedented sample, we create a composite spectrum in the rest-frame of 102,150 quasar spectra from 800–3300 Å at a signal-to-noise ratio close to 1000 per pixel (Δv of 69 km s−1). Included in this analysis is a correction to account for flux calibration residuals in the BOSS spectrophotometry. We determine the spectral index as a function of redshift of the full sample, warp the composite spectrum to match the median spectral index, and compare the resulting spectrum to Sloan Digital Sky Survey (SDSS) photometry used in target selection. The quasar composite matches the color of the quasar population to 0.02 mag in g − r, 0.03 mag in r − i, and 0.01 mag in i − z over the redshift range 2.2 < z < 2.6. The composite spectrum deviates from the imaging photometry by 0.05 mag around z = 2.7, likely due to differences in target selection as the quasar colors become similar to the stellar locus at this redshift. Finally, we characterize the line features in the high signal-to-noise composite and identify nine faint lines not found in the previous composite spectrum from SDSS.
ASSESSMENT OF SYSTEMATIC CHROMATIC ERRORS THAT IMPACT SUB-1% PHOTOMETRIC PRECISION IN LARGE-AREA SKY SURVEYS
Authors: Li T. S. , DePoy D. L. , Marshall J. L. , Tucker D. , Kessler R. , Annis J. , Bernstein G. M. , Boada S. , Burke D. L. , Finley D. A. , James D. J. , Kent S. , Lin H. , Marriner J. , Mondrik N. , Nagasawa D. , Rykoff E. S. , Scolnic D. , Walker A. R. , Wester W. , Abbott T. M. C. , Allam S. , Benoit-Lévy A. , Bertin E. , Brooks D. , Capozzi D. , Rosell A. Carnero , Kind M. Carrasco , Carretero J. , Crocce M. , Cunha C. E. , D’Andrea C. B. , Costa L. N. da , Desai S. , Diehl H. T. , Doel P. , Flaugher B. , Fosalba P. , Frieman J. , Gaztanaga E. , Goldstein D. A. , Gruen D. , Gruendl R. A. , Gutierrez G. , Honscheid K. , Kuehn K. , Kuropatkin N. , Maia M. A. G. , Melchior P. , Miller C. J. , Miquel R. , Mohr J. J. , Neilsen E. , Nichol R. C. , Nord B. , Ogando R. , Plazas A. A. , Romer A. K. , Roodman A. , Sako M. , Sanchez E. , Scarpine V. , Schubnell M. , Sevilla-Noarbe I. , Smith R. C. , Soares-Santos M. , Sobreira F. , Suchyta E. , Tarle G. , Thomas D. , Vikram V. ,   (The DES Collaboration)
Published: May 2016

ABSTRACT
Meeting the science goals for many current and future ground-based optical large-area sky surveys requires that the calibrated broadband photometry is both stable in time and uniform over the sky to 1% precision or better. Past and current surveys have achieved photometric precision of 1%–2% by calibrating the survey’s stellar photometry with repeated measurements of a large number of stars observed in multiple epochs. The calibration techniques employed by these surveys only consider the relative frame-by-frame photometric zeropoint offset and the focal plane position-dependent illumination corrections, which are independent of the source color. However, variations in the wavelength dependence of the atmospheric transmission and the instrumental throughput induce source color-dependent systematic errors. These systematic errors must also be considered to achieve the most precise photometric measurements. In this paper, we examine such systematic chromatic errors (SCEs) using photometry from the Dark Energy Survey (DES) as an example. We first define a natural magnitude system for DES and calculate the systematic errors on stellar magnitudes when the atmospheric transmission and instrumental throughput deviate from the natural system. We conclude that the SCEs caused by the change of airmass in each exposure, the change of the precipitable water vapor and aerosol in the atmosphere over time, and the non-uniformity of instrumental throughput over the focal plane can be up to 2% in some bandpasses. We then compare the calculated SCEs with the observed DES data. For the test sample data, we correct these errors using measurements of the atmospheric transmission and instrumental throughput from auxiliary calibration systems. The residual after correction is less than 0.3%. Moreover, we calculate such SCEs for Type Ia supernovae and elliptical galaxies and find that the chromatic errors for non-stellar objects are redshift-dependent and can be larger than those for stars at certain redshifts.
TRIPPy: TRAILED IMAGE PHOTOMETRY IN PYTHON
Authors: Fraser Wesley , Alexandersen Mike , Schwamb Megan E. , Marsset Michaël , Pike Rosemary E. , Kavelaars J. J. , Bannister Michele T. , Benecchi Susan , Delsanti Audrey 
Published: May 2016

ABSTRACT
Photometry of moving sources typically suffers from a reduced signal-to-noise ratio (S/N) or flux measurements biased to incorrect low values through the use of circular apertures. To address this issue, we present the software package, TRIPPy: TRailed Image Photometry in Python. TRIPPy introduces the pill aperture, which is the natural extension of the circular aperture appropriate for linearly trailed sources. The pill shape is a rectangle with two semicircular end-caps and is described by three parameters, the trail length and angle, and the radius. The TRIPPy software package also includes a new technique to generate accurate model point-spread functions (PSFs) and trailed PSFs (TSFs) from stationary background sources in sidereally tracked images. The TSF is merely the convolution of the model PSF, which consists of a moffat profile, and super-sampled lookup table. From the TSF, accurate pill aperture corrections can be estimated as a function of pill radius with an accuracy of 10 mmag for highly trailed sources. Analogous to the use of small circular apertures and associated aperture corrections, small radius pill apertures can be used to preserve S/Ns of low flux sources, with appropriate aperture correction applied to provide an accurate, unbiased flux measurement at all S/Ns.
PLANET HUNTERS. X. SEARCHING FOR NEARBY NEIGHBORS OF 75 PLANET AND ECLIPSING BINARY CANDIDATES FROM THE K2 KEPLER EXTENDED MISSION
Authors: Schmitt Joseph R. , Tokovinin Andrei , Wang Ji , Fischer Debra A. , Kristiansen Martti H. , LaCourse Daryll M. , Gagliano Robert , Tan Arvin Joseff V. , Schwengeler Hans Martin , Omohundro Mark R. , Venner Alexander , Terentev Ivan , Schmitt Allan R. , Jacobs Thomas L. , Winarski Troy , Sejpka Johann , Jek Kian J. , Boyajian Tabetha S. , Brewer John M. , Ishikawa Sascha T. , Lintott Chris , Lynn Stuart , Schawinski Kevin , Schwamb Megan E. , Weiksnar Alex 
Published: May 2016

ABSTRACT
We present high-resolution observations of a sample of 75 K2 targets from Campaigns 1–3 using speckle interferometry on the Southern Astrophysical Research (SOAR) telescope and adaptive optics imaging at the Keck II telescope. The median SOAR I-band and Keck K

s
-band detection limits at

1
″

were

Δ

m

I

=
4.4

mag and

Δ

m

K

s

=
6.1

mag, respectively. This sample includes 37 stars likely to host planets, 32 targets likely to be eclipsing binaries (EBs), and 6 other targets previously labeled as likely planetary false positives. We find nine likely physically bound companion stars within

3
″

of three candidate transiting exoplanet host stars and six likely EBs. Six of the nine detected companions are new discoveries. One of these new discoveries, EPIC 206061524, is associated with a planet candidate. Among the EB candidates, companions were only found near the shortest period ones (

P
<
3

days), which is in line with previous results showing high multiplicity near short-period binary stars. This high-resolution data, including both the detected companions and the limits on potential unseen companions, will be useful in future planet vetting and stellar multiplicity rate studies for planets and binaries.
A CHANDRA STUDY OF THE INTERSTELLAR METALLICITY IN THE LARGE MAGELLANIC CLOUD USING SUPERNOVA REMNANTS
Authors: Schenck Andrew , Park Sangwook , Post Seth 
Published: May 2016

ABSTRACT
We report on the results from our measurements of the interstellar medium (ISM) abundances for the elements O, Ne, Mg, Si, and Fe in the Large Magellanic Cloud (LMC). We used the archival Chandra data for sixteen supernova remnants (SNRs) in the LMC (0453-68.5, DEM L71, N23, 0519-69.0, N49B, N132D, N49, N206, 0534-69.9, DEM L238, N63A, Honeycomb, N157B, 0540-69.3, DEM L316B, and 0548-70.4). Our results represent LMC abundance measurements based on the modern Chandra data. We place tight constraints on our measured elemental abundances and find lower abundances than previous measurements by Hughes et al. (by a factor of approximately two on average except for Si) who utilized similar methods based on a smaller sample of ASCA data of SNRs in the LMC. We discuss the origins of the discrepancy between our Chandra and the previous ASCA measurements. We also discuss our results in comparison with the LMC abundance measurements in the literature.
A NON-LTE STUDY OF SILICON ABUNDANCES IN GIANT STARS FROM THE Si i INFRARED LINES IN THE zJ-BAND*
Authors: Tan Kefeng , Shi Jianrong , Takada-Hidai Masahide , Takeda Yoichi , Zhao Gang 
Published: May 2016

ABSTRACT
We investigate the feasibility of Si i infrared (IR) lines as Si abundance indicators for giant stars. We find that Si abundances obtained from the Si i IR lines based on the local thermodynamic equilibrium (LTE) analysis show large line-to-line scatter (mean value of 0.13 dex), and are higher than those from the optical lines. However, when non-LTE effects are taken into account, the line-to-line scatter reduces significantly (mean value of 0.06 dex), and the Si abundances are consistent with those from the optical lines. The typical average non-LTE correction of [Si/Fe] for our sample stars is about −0.35 dex. Our results demonstrate that the Si i IR lines could be reliable abundance indicators, provided that the non-LTE effects are properly taken into account.