bluuebunny/crossref_metadata_2025_split huggingface dataset:
Compact single‐layer depolarizing chipless RFID tag
Authors: Martinez Marcos , van der Weide Daniel 
Published: May 2016

ABSTRACTWe present the first single layer depolarizing chipless RFID tag. The tag is formed by a set of asymmetric hairpin resonators, improving the tag's coding density when compared with previous depolarizing tags. The single layer characteristics of the tags make it possible to print them directly on items or embed them in low profile objects like documents. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1897–1900, 2016
A two port UWB‐dual narrowband antenna for cognitive radios
Authors: Pahadsingh Sasmita , Sahu Sudhakar 
Published: May 2016

ABSTRACTA two port ultra wideband(UWB) and dual narrowband antenna for cognitive radio(CR) applications is reported. In this letter an elliptical patch is used as an UWB sensing antenna which is coplanar waveguide (CPW)‐fed transmission line with elliptically tapered ground plane. A rectangular slot is etched from the radiating patch to integrate the narrow band communication antenna where basically the surface current density is effectively low. Within the slot a triangular monopole with meander line LC (inductance–capacitance) resonator in the feed helps to realize dual narrowband (NB) communication antenna. This proposed antenna is a potential candidate for cognitive radio application where the elliptical patch antenna covers the UWB frequency range (3.1–10.6 GHz) with stable radiation patterns for spectrum sensing and the triangular monopole with meander lines LC resonator in the feed behaves as dual band communication antenna with first band operating at WLAN 5.04 GHz (4.48–5.4 GHz) and second band operating at X band satellite communication at 7.6 GHz (7.4–7.76 GHz) with isolation less than −10 dB in the whole operating band between the two antenna ports. The prototype of the proposed antenna has been fabricated and its S‐parameters in terms of S11, S22, S21 as well as radiation patterns were measured that shows good agreement with simulated results. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:1973–1978, 2016
A novel single‐layer frequency selective surface for gain enhancement of SWB antennas
Authors: Tahir Farooq A. 
Published: May 2016

ABSTRACTA novel frequency selective surface (FSS) and its application for gain enhancement of super‐wideband antennas are demonstrated in this article. The FSS is single layer; still it reflects quite in‐phase over the entire operating bandwidth (2–20 GHz) providing fractional bandwidth more than 163%. The proposed FSS is successfully simulated, fabricated and measured. It has excellent radiation characteristics with the antenna. Measured results show a significant gain improvement (4–5dBi) over 2–20GHz frequency range. The compact single‐layer configuration of the designed FSS provides more flexibility for its mounting close to a radiator making it an attractive candidate for modern applications in C‐band, X‐band, Ku‐band, and K‐band. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:2030–2035, 2016
Modeling 3D thermal fracture propagation by transient cooling using virtual multidimensional internal bonds
Authors: Huang K. , Ghassemi A. 
Published: May 2016

AbstractThermal fracturing can play an important role in development of unconventional petroleum and geothermal resources. Thermal fractures can result from the nonlinear deformation of the rock in response to thermal stress related to cold water injection as well as heating. Before the rock reaches the final failure stage, material softening and bulk modulus degradation can cause changes in the thermo‐mechanical properties of the solid. In order to capture this aspect of the rock fracture, a virtual multidimensional internal bond‐based thermo‐mechanical model is derived to track elastic, softening, and the failure stages of the rock in response to the temporal changes of its temperature field. The variations in thermo‐mechanical properties of the rock are derived from a nonlinear constitutive model. To represent the thermo‐mechanical behavior of pre‐existing fractures, the element partition method is employed. Using the model, numerical simulation of 3D thermal fracture propagation in brittle rock is carried out. Results of numerical simulations provide evidence of model verification and illustrate nonlinear thermal response and fracture development in rock under uniform cooling. In addition, fracture coalescence in a cluster of fractures under thermal stress is illustrated, and the process of thermal fracturing from a wellbore is captured. Results underscore the importance of thermal stress in reservoir stimulation and show the effectiveness of the model to predict 3D thermal fracturing. Copyright © 2016 John Wiley & Sons, Ltd.
Acute lymphoblastic leukemia in a patient with MonoMAC syndrome/GATA2 haploinsufficiency
Authors: Koegel Ashley K. , Hofmann Inga , Moffitt Kristin , Degar Barbara , Duncan Christine , Tubman Venée N. 
Published: May 2016

AbstractPatients with GATA2 haploinsufficiency have a significant predisposition to developing cytopenias, unique infectious manifestations, and myelodysplastic syndrome/acute myeloid leukemia (MDS/AML). We report a unique case of a patient who presented with B‐cell acute lymphoblastic leukemia (B‐ALL) and was subsequently diagnosed with monocytopenia and mycobacterium avium complex (MonoMAC) syndrome/GATA2 haploinsufficiency. The development of MDS/AML in patients with GATA2 haploinsufficiency is well described, however, the development of ALL has not been reported in the literature. ALL may be associated with GATA2 haploinsufficiency. Clinicians should be attuned to the features of the MonoMAC syndrome in patients with ALL that would prompt additional testing and alter treatment.
Pyrrolidine-Acridine hybrid in Artemisinin-based combination: a pharmacodynamic study
Authors: PANDEY SWAROOP KUMAR , BISWAS SUBHASISH , GUNJAN SARIKA , CHAUHAN BHAVANA SINGH , SINGH SUNIL KUMAR , SRIVASTAVA KUMKUM , SINGH SARIKA , BATRA SANJAY , TRIPATHI RENU 
Published: May 2016

SUMMARYAiming to develop new artemisinin-based combination therapy (ACT) for malaria, antimalarial effect of a new series of pyrrolidine-acridine hybrid in combination with artemisinin derivatives was investigated. Synthesis, antimalarial and cytotoxic evaluation of a series of hybrid of 2-(3-(substitutedbenzyl)pyrrolidin-1-yl)alkanamines and acridine were performed and mode of action of the lead compound was investigated. In vivo pharmacodynamic properties (parasite clearance time, parasite reduction ratio, dose and regimen determination) against multidrug resistant (MDR) rodent malaria parasite and toxicological parameters (median lethal dose, liver function test, kidney function test) were also investigated. 6-Chloro-N-(4-(3-(3,4-dimethoxybenzyl)pyrrolidin-1-yl)butyl)-2-methoxyacridin-9-amine (15c) has shown a dose dependent haem bio-mineralization inhibition and was found to be the most effective and safe compound against MDR malaria parasite in Swiss mice model. It displayed best antimalarial potential with artemether (AM) in vitro as well as in vivo. The combination also showed favourable pharmacodynamic properties and therapeutic response in mice with established MDR malaria infection and all mice were cured at the determined doses. The combination did not show toxicity at the doses administered to the Swiss mice. Taken together, our findings suggest that compound 15c is a potential partner with AM for the ACT and could be explored for further development.
Linear algebra software for large-scale accelerated multicore computing
Authors: Abdelfattah A. , Anzt H. , Dongarra J. , Gates M. , Haidar A. , Kurzak J. , Luszczek P. , Tomov S. , Yamazaki I. , YarKhan A. 
Published: May 2016

Many crucial scientific computing applications, ranging from national security to medical advances, rely on high-performance linear algebra algorithms and technologies, underscoring their importance and broad impact. Here we present the state-of-the-art design and implementation practices for the acceleration of the predominant linear algebra algorithms on large-scale accelerated multicore systems. Examples are given with fundamental dense linear algebra algorithms – from the LU, QR, Cholesky, and LDLT factorizations needed for solving linear systems of equations, to eigenvalue and singular value decomposition (SVD) problems. The implementations presented are readily available via the open-source PLASMA and MAGMA libraries, which represent the next generation modernization of the popular LAPACK library for accelerated multicore systems.To generate the extreme level of parallelism needed for the efficient use of these systems, algorithms of interest are redesigned and then split into well-chosen computational tasks. The task execution is scheduled over the computational components of a hybrid system of multicore CPUs with GPU accelerators and/or Xeon Phi coprocessors, using either static scheduling or light-weight runtime systems. The use of light-weight runtime systems keeps scheduling overheads low, similar to static scheduling, while enabling the expression of parallelism through sequential-like code. This simplifies the development effort and allows exploration of the unique strengths of the various hardware components. Finally, we emphasize the development of innovative linear algebra algorithms using three technologies – mixed precision arithmetic, batched operations, and asynchronous iterations – that are currently of high interest for accelerated multicore systems.
The needs of siblings of children with a life-threatening illness, part 2: Psychometric validation of the IBesFEMS
Authors: Olivier d'avignon Marianne , Dumont Serge , Valois Pierre , Cohen S. Robin 
Published: May 2016

AbstractObjective:Life-threatening illnesses in children have a significant impact on the lives of their brothers and sisters. Consequently, special attention must be paid to the specific needs of these siblings to help them cope with their situations. To address this issue, we developed an inventory of the needs of the adolescent siblings of severely ill children, the Inventaire des Besoins de la Fratrie d'Enfants Malades Sévèrement (IBesFEMS) [Needs Inventory for Siblings of Critically Ill Children]. The present article describes a preliminary validation study of this new instrument.Method:In a prospective cohort study, the 48-item instrument was administered via a website or paper to 58 siblings.Results:Our study revealed that the measure has an estimated internal consistency of 0.96 and a temporal stability intraclass correlation coefficient (ICC) of 0.86 (p< 0.01). Its convergence validity is also satisfactory.Significance of results:Our findings suggest that the IBesFEMS is highly relevant for pediatric palliative care clinicians and researchers. Future studies should investigate its factorial structure and predictive validities.
Predictive modelling of ferroelectric tunnel junctions
Authors: Velev Julian P , Burton John D , Zhuravlev Mikhail Ye , Tsymbal Evgeny Y 
Published: May 2016

AbstractFerroelectric tunnel junctions combine the phenomena of quantum-mechanical tunnelling and switchable spontaneous polarisation of a nanometre-thick ferroelectric film into novel device functionality. Switching the ferroelectric barrier polarisation direction produces a sizable change in resistance of the junction—a phenomenon known as the tunnelling electroresistance effect. From a fundamental perspective, ferroelectric tunnel junctions and their version with ferromagnetic electrodes, i.e., multiferroic tunnel junctions, are testbeds for studying the underlying mechanisms of tunnelling electroresistance as well as the interplay between electric and magnetic degrees of freedom and their effect on transport. From a practical perspective, ferroelectric tunnel junctions hold promise for disruptive device applications. In a very short time, they have traversed the path from basic model predictions to prototypes for novel non-volatile ferroelectric random access memories with non-destructive readout. This remarkable progress is to a large extent driven by a productive cycle of predictive modelling and innovative experimental effort. In this review article, we outline the development of the ferroelectric tunnel junction concept and the role of theoretical modelling in guiding experimental work. We discuss a wide range of physical phenomena that control the functional properties of ferroelectric tunnel junctions and summarise the state-of-the-art achievements in the field.
Ocean acidification reverses the positive effects of seawater pH fluctuations on growth and photosynthesis of the habitat-forming kelp, Ecklonia radiata
Authors: Britton Damon , Cornwall Christopher E. , Revill Andrew T. , Hurd Catriona L. , Johnson Craig R. 
Published: May 2016

AbstractOcean acidification (OA) is the reduction in seawater pH due to the absorption of human-released CO2 by the world’s oceans. The average surface oceanic pH is predicted to decline by 0.4 units by 2100. However, kelp metabolically modifies seawater pH via photosynthesis and respiration in some temperate coastal systems, resulting in daily pH fluctuations of up to ±0.45 units. It is unknown how these fluctuations in pH influence the growth and physiology of the kelp, or how this might change with OA. In laboratory experiments that mimicked the most extreme pH fluctuations measured within beds of the canopy-forming kelp Ecklonia radiata in Tasmania, the growth and photosynthetic rates of juvenile E. radiata were greater under fluctuating pH (8.4 in the day, 7.8 at night) than in static pH treatments (8.4, 8.1, 7.8). However, pH fluctuations had no effect on growth rates and a negative effect on photosynthesis when the mean pH of each treatment was reduced by 0.3 units. Currently, pH fluctuations have a positive effect on E. radiata but this effect could be reversed in the future under OA, which is likely to impact the future ecological dynamics and productivity of habitats dominated by E. radiata.
Protective effect of in ovo treatment with the chicken cathelicidin analog D-CATH-2 against avian pathogenic E. coli
Authors: Cuperus Tryntsje , van Dijk Albert , Matthijs Mieke G. R. , Veldhuizen Edwin J. A. , Haagsman Henk P. 
Published: May 2016

AbstractIncreasing antibiotic resistance and ever stricter control on antibiotic use are a driving force to develop alternatives to antibiotics. One such strategy is the use of multifunctional Host Defense Peptides. Here we examined the protective effect of prophylactic treatment with the D analog of chicken cathelicidin-2 (D-CATH-2) against a respiratory E. coli infection. Chickens were treated with D-CATH-2 in ovo at day 18 of embryonic development or intramuscularly at days 1 and 4 after hatch. At 7 days of age, birds were challenged intratracheally with avian pathogenic E. coli. Protection was evaluated by recording mortality, morbidity (Mean Lesion Score) and bacterial swabs of air sacs at 7 days post-infection. In ovo D-CATH-2 treatment significantly reduced morbidity (63%) and respiratory bacterial load (>90%), while intramuscular treatment was less effective. D-CATH-2 increased the percentage of peripheral blood lymphocytes and heterophils by both administration routes. E. coli specific IgM levels were lower in in ovo treated animals compared to intramuscular D-CATH-2 treatment. In short, in ovo treatment with the Host Defense Peptide derived D-CATH-2 can partially protect chickens from E. coli infection, making this peptide an interesting starting point to develop alternatives to antibiotics for use in the poultry sector.
Relationship of Serum Trimethylamine N-Oxide (TMAO) Levels with early Atherosclerosis in Humans
Authors: Randrianarisoa Elko , Lehn-Stefan Angela , Wang Xiaolin , Hoene Miriam , Peter Andreas , Heinzmann Silke S , Zhao Xinjie , Königsrainer Ingmar , Königsrainer Alfred , Balletshofer Bernd , Machann Jürgen , Schick Fritz , Fritsche Andreas , Häring Hans-Ulrich , Xu Guowang , Lehmann Rainer , Stefan Norbert 
Published: May 2016

AbstractCirculating trimethylamine N-Oxide (TMAO) levels predict cardiovascular disease (CVD), possibly by impacting on cholesterol metabolism and oxidative stress. Because hepatic TMAO production is regulated by insulin signalling and it is unclear whether and to what extent circulating TMAO levels associate with CVD risk, independently of insulin resistance and its important determinants fatty liver and visceral obesity, we have now addressed this question in 220 subjects who participated in the Tübingen Lifestyle Intervention Program. Visceral fat mass (r = 0.40, p < 0.0001), liver fat content (r = 0.23, p = 0.0005) and TMAO levels (r = 0.26, p < 0.0001) associated positively and insulin sensitivity associated negatively (r = −0.18, p = 0.009) with carotid intima-media thickness (cIMT). Higher TMAO levels (std.−Beta 0.11, p = 0.03) predicted increased cIMT, independently of age, sex and visceral fat mass. While during the lifestyle intervention most cardiovascular risk parameters improved, mean TMAO levels did not change (p = 0.18). However, cIMT decreased significantly (p = 0.0056) only in subjects in the tertile with the largest decrease of TMAO levels (>20%). We provide novel information that increased serum TMAO levels associate with increased cIMT, independently of established cardiovascular risk markers, including insulin resistance, visceral obesity and fatty liver. Furthermore, the decrease of cIMT during a lifestyle intervention may be related to the decrease of TMAO levels.
Efficient suilysin-mediated invasion and apoptosis in porcine respiratory epithelial cells after streptococcal infection under air-liquid interface conditions
Authors: Meng Fandan , Wu Nai-Huei , Seitz Maren , Herrler Georg , Valentin-Weigand Peter 
Published: May 2016

AbstractStreptococci may colonize the epithelium in the airways and other entry sites. While local infection often remains asymptomatic, severe or even fatal diseases occur when streptococci become invasive and spread to different sites in the infected host. We have established porcine respiratory air-liquid interface cultures (ALI) from the porcine lung to analyze the interaction of streptococci with their primary target cells. As representative of the streptococcal family we chose Streptococcus suis (S. suis) that is not only a major swine respiratory pathogen but can also infect humans. Suilysin, a cholesterol-dependent cytolysin (CDC), is an important virulence factor. By comparing a S. suis wt strain with a suilysin-deficient mutant, we demonstrate that suilysin contributes to (i) adherence to airway cells (ii) loss of ciliated cells (iii) apoptosis and (iv) invasion. Furthermore, we show that cytolytic activity of suilysin is crucial for these effects. A striking result of our analysis was the high efficiency of S. suis-induced apoptosis and invasion upon infection under ALI conditions. These properties have been reported to be less efficient when analyzed with immortalized cells. We hypothesize that soluble effectors such as suilysin are present at higher concentrations in cells kept at ALI conditions and thus more effective. These results should be relevant also for infection of the respiratory tract by other respiratory pathogens.
Continuity of Monolayer-Bilayer Junctions for Localization of Lipid Raft Microdomains in Model Membranes
Authors: Ryu Yong-Sang , Wittenberg Nathan J. , Suh Jeng-Hun , Lee Sang-Wook , Sohn Youngjoo , Oh Sang-Hyun , Parikh Atul N. , Lee Sin-Doo 
Published: May 2016

AbstractWe show that the selective localization of cholesterol-rich domains and associated ganglioside receptors prefer to occur in the monolayer across continuous monolayer-bilayer junctions (MBJs) in supported lipid membranes. For the MBJs, glass substrates were patterned with poly(dimethylsiloxane) (PDMS) oligomers by thermally-assisted contact printing, leaving behind 3 nm-thick PDMS patterns. The hydrophobicity of the transferred PDMS patterns was precisely tuned by the stamping temperature. Lipid monolayers were formed on the PDMS patterned surface while lipid bilayers were on the bare glass surface. Due to the continuity of the lipid membranes over the MBJs, essentially free diffusion of lipids was allowed between the monolayer on the PDMS surface and the upper leaflet of the bilayer on the glass substrate. The preferential localization of sphingomyelin, ganglioside GM1 and cholesterol in the monolayer region enabled to develop raft microdomains through coarsening of nanorafts. Our methodology provides a simple and effective scheme of non-disruptive manipulation of the chemical landscape associated with lipid phase separations, which leads to more sophisticated applications in biosensors and as cell culture substrates.
Characterisation of assembly and ubiquitylation by the RBCC motif of Trim5α
Authors: Keown Jeremy R. , Yang Joy X. , Douglas Jordan , Goldstone David C. 
Published: May 2016

AbstractThe post-entry restriction factor Trim5α blocks infection of retroviral pathogens shortly after the virus gains entry to the cell, preventing reverse transcription and integration into the host genome. Central to the mechanism of restriction is recognition of the lattice of capsid protein that forms the inner-shell of the retrovirus. To recognise this lattice, Trim5α has been shown to assemble into a large hexagonal array, complementary to the capsid lattice. Structures of the Trim5α coiled-coil region reveal an elongated anti-parallel dimer consistent with the edges of this array placing the Bbox domain at each end of the coiled-coil to facilitate assembly. To investigate the nature of this assembly we have designed and characterised a monomeric version of the TRIM RBCC motif with a truncated coiled-coil. Biophysical characterisation by SEC-MALLS, AUC and SAXS demonstrate that this construct forms compact folded domain that assembles into a trimer that would support the formation of a hexagonal lattice. Furthermore, the RING domain and elements of the coiled-coil region are shown to contribute to assembly. Ubiquitylation assays demonstrate that this assembly increases ubiquitylation activity providing a link from recognition of the capsid lattice and assembly to the activation of innate immune signalling and restriction.
Farnesiferol c induces apoptosis via regulation of L11 and c-Myc with combinational potential with anticancer drugs in non-small-cell lung cancers
Authors: Jung Ji Hoon , Kim Moon Joon , Lee Hyemin , Lee Jihyun , Kim Jaekwang , Lee Hyun Joo , Shin Eun Ah , Kim Yoon Hyeon , Kim Bonglee , Shim Bum Sang , Kim Sung-Hoon 
Published: May 2016

AbstractThough Farnesiferol c (FC) has been reported to have anti-angiogenic and antitumor activity, the underlying antitumor mechanism of FC still remains unclear. Thus, in the present study, we investigated the apoptotic mechanism of FC in human H1299 and H596 non-small lung cancer cells (NSCLCs). FC significantly showed cytotoxicity, increased sub-G1 accumulation, and attenuated the expression of Bcl-2, Bcl-xL, Survivin and procaspase 3 in H1299 and H596 cells. Furthermore, FC effectively suppressed the mRNA expression of G1 arrest related genes such as Cyclin D1, E2F1 transcription factor and CDC25A by RT-PCR. Interestingly, FC inhibited the expression of c-Myc, ribosomal protein L11 (L11) and nucleolin (NCL) in H1299 and H596 cells. Of note, silencing of L11 by siRNA transfection enhanced the expression of c-Myc through a negative feedback mechanism, while c-Myc knockdown downregulated L11 in H1299 cells. Additionally, combined treatment of FC and puromycin/doxorubicin promoted the activation of caspase 9/3, and attenuated the expression of c-Myc, Cyclin D1 and CDK4 in H1299 cells compared to single treatment. Taken together, our findings suggest that FC induces apoptosis and G1 arrest via regulation of ribosomal protein L11 and c-Myc and also enhances antitumor effect of puromycin or doxorubicin in NSCLCs.