bluuebunny/crossref_metadata_2025_split huggingface dataset:
Artemisia arborescens Essential Oil Composition, Enantiomeric Distribution, and Antimicrobial Activity from Different Wild Populations from the Mediterranean Area
Authors: Said Mohammed El‐Amin , Militello Marcello , Saia Sergio , Settanni Luca , Aleo Aurora , Mammina Caterina , Bombarda Isabelle , Vanloot Pierre , Roussel Christian , Dupuy Nathalie 
Published: July 2016

Aerial parts of Artemisia arborescens were collected from different sites of the Mediterranean area (southwestern Algeria and southern Italy) and the chemical composition of their essential oil (EO) extracted by hydrodistillation was studied by both gas chromatography (GC) equipped with an enantioselective capillary column and GC/mass spectrometry (GC/MS). The EOs obtained were tested against several Listeria monocytogenes strains. Using GC and GC/MS, 41 compounds were identified, accounting for 96.0 – 98.8% of the total EO. All EOs showed a similar terpene profile, which was rich in chamazulene, β‐thujone, and camphor. However, the concentration of such compounds varied among the EOs. A. arborescens EO inhibited up to 83.3% of the L. monocytogenes strains, but the inhibitory spectrum varied among the EOs, with those from Algeria showing a higher inhibition degree than the Italian EOs. Such effect likely depended on the ketone (β‐thujone + camphor) content of the EO. The differences in the EO composition support the hypothesis that A. arborescens has at least two different chemotypes: a β‐thujone and a chamazulene type. The EO inhibitory spectrum indicates the A. arborescens EO as a valuable option in the control of the food‐borne pathogens.
Chemical Variability and Biological Activities of Essential Oils of Micromeria inodora (Desf.) Benth. from Algeria
Authors: Benomari Fatima Zahra , Djabou Nassim , Medbouhi Ali , Khadir Abdelmounaim , Bendahou Mourad , Selles Chaouki , Desjobert Jean‐Marie , Costa Jean , Muselli Alain 
Published: July 2016

The chemical composition of the essential oils isolated from the aerial parts of Micromeria inodora (Desf.) Benth. collected in 24 Algerian localities was investigated from the first time using GC‐FID, GC/MS and 13C‐NMR. Altogether, 83 components which accounted for 94.7% of the total oil composition were identified. The main compounds were trans‐sesquisabinene hydrate (1; 20.9%), α‐terpinyl acetate (2; 19.8%), globulol (3; 4.9%), caryophyllene oxide (4; 4.3%), β‐bisabolol (5; 2.9%) and trans‐7‐epi‐sesquisabinene hydrate (6; 2.6%). Comparison with the literature highlighted the originality of the Algerian M. inodora oil and indicated that 1 might be used as taxonomical marker. The study of the chemical variability allowed the discrimination of two main clusters confirming that there is a relation between the essential‐oil compositions and the soil nature of the harvest locations. Biological activity of M. inodora essential oil was assessed against fourteen species of microorganisms involved in nosocomial infections using paper disc diffusion and dilution agar assays. The in vitro study demonstrated a good activity against Gram‐positive strains such as Staphylococcus aureus, Bacillus cereus, Bacillus subtilis, and Enterococcus faecalis, and moderate activity against Candida albicans. These results might be useful for the future commercial valorization of M. inodora essential oil as a promising source of natural products with potential against various nosocomial community and toxinic infections.
Antifungal Monoterpene Derivatives from the Plant Endophytic Fungus Pestalotiopsis foedan
Authors: Xu Dan , Zhang Bing‐Yang , Yang Xiao‐Long 
Published: July 2016

A new monoterpene lactone, (1R,4R,5R,8S)‐8‐hydroxy‐4,8‐dimethyl‐2‐oxabicyclo[3.3.1]nonan‐3‐one (1), along with one related known compound, (2R)‐2‐[(1R)‐4‐methylcyclohex‐3‐en‐1‐yl]propanoic acid (2), were isolated from the liquid culture of the plant endophytic fungus Pestalotiopsis foedan obtained from the branch of Bruguiera sexangula. The structure and absolute configuration of 1 were determined on the basis of extensive analysis of NMR spectra combined with computational methods via calculation of the optical rotation (OR) and 13C‐NMR. Both compounds exhibited strong antifungal activities against Botrytis cinerea and Phytophthora nicotianae with MIC values of 3.1 and 6.3 μg/ml, respectively, which are comparable to those of the known antifungal drug ketoconazole. Compound 2 also showed modest antifungal activity against Candida albicans with a MIC value of 50 μg/ml.
The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering
Authors: van der Meer Jan‐Ytzen , Biewenga Lieuwe , Poelarends Gerrit J. 
Published: July 2016

AbstractThe increasing number of enzyme applications in chemical synthesis calls for new engineering methods to develop the biocatalysts of the future. An interesting concept in enzyme engineering is the generation of large‐scale mutational data in order to chart protein mutability landscapes. These landscapes allow the important discrimination between beneficial mutations and those that are neutral or detrimental, thus providing detailed insight into sequence–function relationships. As such, mutability landscapes are a powerful tool with which to identify functional hotspots at any place in the amino acid sequence of an enzyme. These hotspots can be used as targets for combinatorial mutagenesis to yield superior enzymes with improved catalytic properties, stability, or even new enzymatic activities. The generation of mutability landscapes for multiple properties of one enzyme provides the exciting opportunity to select mutations that are beneficial either for one or for several of these properties. This review presents an overview of the recent advances in the construction of mutability landscapes and discusses their importance for enzyme engineering.
Reduced Graphene Oxide as a Metal‐Free Catalyst for the Light‐Assisted Fenton‐Like Reaction
Authors: Espinosa Juan C. , Navalón Sergio , Álvaro Mercedes , García Hermenegildo 
Published: July 2016

AbstractNatural sunlight irradiation increases the catalytic activity of reduced graphene oxide (rGO) as metal‐free Fenton‐like catalyst for phenol degradation. Generation of hydroxyl radical intermediates was confirmed by EPR spectroscopy using a spin‐trapping agent.
Copper‐Catalyzed Skeletal Rearrangement of O‐Propargyl Oximes: A Mechanistic Manifold
Authors: González Comesaña Marta , Nieto Faza Olalla , Cid María Magdalena , Silva López Carlos 
Published: July 2016

AbstractThe Cu‐mediated skeletal rearrangement of O‐propargyl oximes features a mechanistic manifold that yields different compounds. Strategic modification of the substituent at the oxime moiety (R3) allows the selection of a preferred mechanistic route that leads to azete oxides/amidodienes (if R3 is an electron‐poor/‐rich aryl group) or to pyridine N‐oxides (if R3 is an olefin). In the present work, we explore the mechanism that leads to each product. All the computed mechanisms have in common an initial stepwise 2,3‐rearrangement that generates the key N‐allenylnitrone intermediate the further reactivity of which will depend on the nature of the R3 substituent. Our calculations reveal the subtle details that govern the different behavior of this reaction with each of the aforementioned substituents and disclose a complex and multistep pathway to different aminodienes.
Extraction of Anthocyanins Using a Laboratory Robot and Innovative Extraction Technologies
Authors: Bachtler Simone , Bart Hans‐Jörg 
Published: July 2016

AbstractSolid‐liquid extraction using a laboratory robot, where anthocyanins are leached from dried red vine leaves, is evaluated with respect to precision and accuracy. The solid handling of the robot results in standard deviations between ± 0.6 and ± 1.8 depending on the particle size. For liquid handling the standard deviations are slightly higher depending on the volatility of the solvents. The validated, fully automated natural plant extraction robot achieves varying yields based on dry matter for methanol, water, and ethanol which are improved with increasing particle size. Manually performed extraction kinetics experiments are compared with the robot. With respect to process intensification, a comparison of yields obtained by microwave‐ and ultrasonic‐supported extraction compared to laboratory robot shaking and stirred single‐stage batch experiments was performed.
Iridium(I) Compounds as Prospective Anticancer Agents: Solution Chemistry, Antiproliferative Profiles and Protein Interactions for a Series of Iridium(I) N‐Heterocyclic Carbene Complexes
Authors: Gothe Yvonne , Marzo Tiziano , Messori Luigi , Metzler‐Nolte Nils 
Published: July 2016

AbstractA series of structurally related mono‐ and bis‐NHC–iridium(I) (NHC: N‐heterocyclic carbene) complexes have been investigated for their suitability as potential anticancer drugs. Their spectral behaviour in aqueous buffers under physiological‐like conditions and their cytotoxicity against the cancer cell lines MCF‐7 and HT‐29 are reported. Notably, almost all complexes exhibit significant cytotoxic effects towards both cancer cell lines. In general, the cationic bis‐carbene complexes show higher stability and greater anticancer activity than their neutral mono‐carbene analogues with IC50 values in the high nanomolar range. Furthermore, to gain initial mechanistic insight, the interactions of these iridium(I)–NHC complexes with two model proteins, namely lysozyme and cytochrome c, were explored by HR‐ESI‐MS analyses. The different protein metalation patterns of the complexes can be roughly classified into two distinct groups. Those interactions give us a first idea about the possible mechanism of action of this class of compounds. Overall, our findings show that iridium(I)–NHC complexes represent very interesting candidates for further development as new metal‐based anticancer drugs.
ChemInform Abstract: Carbonate‐Bridged Lanthanoid Triangles: Single‐Molecule Magnet Behavior, Inelastic Neutron Scattering, and ab initio Studies.
Authors: Giansiracusa Marcus J. , Vonci Michele , Van den Heuvel Willem , Gable Robert W. , Moubaraki Boujemaa , Murray Keith S. , Yu Dehong , Mole Richard A. , Soncini Alessandro , Boskovic Colette 
Published: July 2016

AbstractCompounds (IV) are characterized by single crystal XRD, magnetic measurements, inelastic neutron scattering, and CASSCF ab initio calculations.
ChemInform Abstract: Direct Electrophilic (Benzenesulfonyl)difluoromethylthiolation with a Shelf‐Stable Reagent.
Authors: Ismalaj Ermal , Le Bars Didier , Billard Thierry 
Published: July 2016

AbstractThe gram‐scale preparation of (benzenesulfonyl)difluoromethanesulfenamide is described and its electrophilic addition to terminal and internal alkenes, including cyclic ones, and alkynes as well as its electrophilic aromatic substitution of electron‐rich arenes and heteroarenes.
ChemInform Abstract: Synthesis of α‐Aminonitriles via a FeSO4‐Mediated Oxidative Cyanation of Tertiary Amines with Benzoyl Cyanide and Molecular Oxygen or TBHP.
Authors: Zhang Lianpeng , Gu Xin , Lu Ping , Wang Yanguang 
Published: July 2016

AbstractConcerning the mechanism, a cascade way involving a Fe‐catalyzed oxidation of tertiary amine to iminium ions and trapping them by cyanide anion is suggested.
ChemInform Abstract: Trifluorination of Sulfides and Dithioketals Using IF5‐Pyridine‐HF.
Authors: Inoue Toshiya , Nakabo Sho , Hara Shoji 
Published: July 2016

AbstractThe stable fluorination reagent is used for the trifluorination of aryl alkyl sulfides with concomitant migration of the arylsulfanyl group.
ChemInform Abstract: Catalytic Enantioselective Synthesis of Amino Skipped Diynes.
Authors: Paioti Paulo H. S. , Abboud Khalil A. , Aponick Aaron 
Published: July 2016

AbstractNonracemic amino skipped diynes are prepared via an enantiodetermining C—C bond formation in excellent enantiomeric excess and with extremely broad substrate scope.
ChemInform Abstract: Sequential Functionalization of the O—H and C(sp2)—O Bonds of Tropolones by Alkynes and N‐Sulfonyl Azides.
Authors: Seo Boram , Jeon Woo Hyung , Kim Chul‐Eui , Kim Sanghyuck , Kim Sung Hong , Lee Phil Ho 
Published: July 2016

AbstractIn addition to the title reaction various 2‐functionalizations of tropones with 4‐aryl or 4‐alkyl substituted N‐sulfonyl‐1,2,3‐triazoles are described.
ChemInform Abstract: A Magnetically Recyclable Iron Oxide‐Supported Copper Oxide Nanocatalyst (Fe3O4—CuO) for One‐Pot Synthesis of S‐Aryl Dithiocarbamates under Solvent‐Free Conditions.
Authors: Aryanasab F. 
Published: July 2016

AbstractThe title dithiocarbamates are conveniently and efficiently obtained by simple one‐pot three‐component Ullmann‐type condensation of amines, carbon disulfide, and aryl iodides.
ChemInform Abstract: A Four‐Step Route to Synthetic Equivalents of ortho‐Xylylenes: Doetz Benzannulation, Desilylation, Bromo‐Dehydroxylation, and Sultine Formation. A Concise Approach to Oxygenated Linearly Fused Polycyclic Aromatics.
Authors: Kotha Sambasivarao , Aswar Vikas R. , Manchoju Amarender 
Published: July 2016

AbstractA new route is reported for the synthesis of densely oxygenated polycyclic aromatic compounds, such as (VII), (XI), and (XIII).
ChemInform Abstract: Nickel(II)‐Catalyzed Enantioselective Cyclopropanation of 3‐Alkenyl‐oxindoles with Phenyliodonium Ylide via Free Carbene.
Authors: Guo Jing , Liu Yangbin , Li Xiangqiang , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: July 2016

AbstractThe title reaction affords spirocyclopropane‐oxindoles with contiguous tertiary and quaternary centers in high yields with excellent diastereo‐ and enantioselectivities through a stepwise biradical mechanism.
ChemInform Abstract: A One‐Pot Method for the Preparation of 2,5‐Diarylthiophene‐1‐oxides from Arylacetylenes.
Authors: Miller Robert W. , Dodge Nicholas J. , Dyer Adam M. , Fortner‐Buczala Eleanor M. , Whalley Adam C. 
Published: July 2016

AbstractThe title thiopheneoxides are prepared from readily available arylacetylene precursors via zirconacyclopentadiene intermediates in modest yields without over‐oxidation byproducts.
ChemInform Abstract: Synergistic Acid‐Catalyzed Synthesis of N‐Aryl‐Substituted Azacycles from Anilines and Cyclic Ethers.
Authors: Zhang Zhenbei , Miao Chengxia , Xia Chungu , Sun Wei 
Published: July 2016

AbstractThe environmentally benign metal‐free method produces water as the only side product.
ChemInform Abstract: Indole Synthesis Through Sequential Electrophilic N—H and C—H Bond Activation Using Iodine(III) Reactivity.
Authors: Fra Laura , Muniz Kilian 
Published: July 2016

AbstractFour different conditions A)—D), which all contain an iodine agent in either stoichiometric or catalytic amount, are elaborated for the cyclization of aromatic sulfonamide precursors bearing an alkyne side chain, as is demonstrated for the examples (Ia) and (Ib).
ChemInform Abstract: Asymmetric Tandem Hemiaminal‐Heterocyclization‐Aza‐Mannich Reaction of 2‐Formylbenzonitriles and Amines Using Chiral Phase Transfer Catalysis: An Experimental and Theoretical Study
Authors: Capobianco Amedeo , Di Mola Antonia , Intintoli Valentina , Massa Antonio , Capaccio Vito , Roiser Lukas , Waser Mario , Palombi Laura 
Published: July 2016

Abstractfor the synthesis of 3‐amino‐substituted isoindolinones
ChemInform Abstract: CO2 Fixation at Atmospheric Pressure: Porous ZnSnO3 Nanocrystals as a Highly Efficient Catalyst for the Synthesis of Cyclic Carbonates.
Authors: Roy Susmita , Banerjee Biplab , Bhaumik Asim , Islam Sk. Manirul 
Published: July 2016

AbstractThe catalyst can be efficiently recycled and reused for five times without significant loss of activity.
ChemInform Abstract: Diastereoselective Passerini Reaction of Biobased Chiral Aldehydes: Divergent Synthesis of Various Polyfunctionalized Heterocycles.
Authors: Moni Lisa , Banfi Luca , Basso Andrea , Martino Elisa , Riva Renata 
Published: July 2016

AbstractNoteworthy, the carboxylic component of the Passerini reaction is the acetic acid in situ formed as the side product by the reduction of diacetoxyiodobenzene.
ChemInform Abstract: A Synthesis of 1H‐Indazoles via a Cu(OAc)2‐Catalyzed N—N Bond Formation.
Authors: Chen Cheng‐yi , Tang Guangrong , He Fengxian , Wang Zhaobin , Jing Hailin , Faessler Roger 
Published: July 2016

AbstractA variety of 1H‐indazoles is readily prepared by reaction of nitriles (I) with Grignard reagents followed by a copper‐catalyzed oxidative cyclization of intermediate ketimines.
ChemInform Abstract: A Strecker Approach to 2‐Substituted Ethyl 5‐Aminothiazole‐4‐carboxylates.
Authors: Cheng Ken , McClory Andrew , Walker Whitney , Xu Jie , Zhang Haiming , Angelaud Remy , Gosselin Francis 
Published: July 2016

AbstractThe three step sequence for the synthesis of the title thiazoles involves the 1,2‐addition of thioamides to glyoxylate (II), the treatment with acetyl chloride, and finally the Strecker addition‐cyclization reaction of the resulting imine precursors.
ChemInform Abstract: Visible‐Light Promoted Intermolecular Halofunctionalization of Alkenes with N‐Halogen Saccharins.
Authors: Song Lu , Luo Sanzhong , Cheng Jin‐Pei 
Published: July 2016

AbstractThe photoreaction of N‐bromosaccharin with a range of alkenes leads to a mixture of bromoamide (V) and bromoether (VI).
ChemInform Abstract: Orthogonal Dual‐Click Diyne for CuAAC and/or SPAAC Couplings.
Authors: Ramsubhag Ron R. , Dudley Gregory B. 
Published: July 2016

AbstractCarbamate‐tethered propargyl and benzocyclononyne moieties within a single molecular unit undergo cycloaddition with azides under complementary copper‐catalyzed azide—alkyne cycloaddition and/or strain‐promoted azide—alkyne cycloaddition coupling conditions.
ChemInform Abstract: What Happens when the Terminal Aromatization Is Blocked? Construction of 1,2‐Dihydroquinoline Derivatives by (sp3) C—H Bond Oxidation of N‐Arylalaninates.
Authors: Lue Shiwei , Zhu Yingzu , Ma Xingge , Jia Xiaodong 
Published: July 2016

AbstractDepending on the substrates′ functional groups 1,2‐dihydroquinolines are formed with moderate to very high yields.
ChemInform Abstract: Rhodium(II)‐Catalyzed Intramolecular Annulation of 1‐Sulfonyl‐1,2,3‐triazoles with Indoles: Facile Synthesis of Functionalized Tetrahydro‐β‐carbolines.
Authors: Shang Hai , Tian Yu , Luo Jun , Li Lingyu , Tang Yefeng , Zou Zhongmei 
Published: July 2016

AbstractAn efficient method for the synthesis of 4‐substituted tetrahydro‐β‐carbolines from readily available starting materials is demonstrated.
ChemInform Abstract: A One‐Pot Synthesis of Trichloromethylated Pyrimidines from Trichloroacetimidamides and Acetylenic Esters.
Authors: Yavari Issa , Malekafzali Alaleh , Eivazzadeh‐Keihan Reza , Skoulika Stavroula , Alivaisi Rahman 
Published: July 2016

AbstractTrichloroacetimidamides generated in situ from guanidines and trichloroacetonitrile undergo an addition reaction with acetylenic esters to afford highly functionalized pyrimidine derivatives.
ChemInform Abstract: Synthesis of Fused Isoquinolines via Gold‐Catalyzed Tandem Alkyne Amination/Intramolecular O—H Insertion.
Authors: Pan Yuan , Chen Gui‐Wei , Shen Cang‐Hai , He Weimin , Ye Long‐Wu 
Published: July 2016

AbstractA series of oxazinoisoquinolines is prepared by a tandem alkyne amination/intramolecular O—H insertion.
ChemInform Abstract: Copper‐Catalyzed Regio‐ and Enantioselective Aminoboration of Alkylidenecyclopropanes: The Synthesis of Cyclopropane‐Containing β‐Aminoalkylboranes.
Authors: Jiang Han‐Chun , Tang Xiang‐Ying , Shi Min 
Published: July 2016

AbstractThe reaction works well with cyclopropylidenetoluenes only.
ChemInform Abstract: Rhodium‐Catalyzed Cycloisomerization of 2‐Silylethynyl Phenols and Anilines via 1,2‐Silicon Migration
Authors: Kanno Hiroshi , Nakamura Kyosuke , Noguchi Keiichi , Shibata Yu , Tanaka Ken 
Published: July 2016

Abstractaffording silylbenzofurans and silylindoles
ChemInform Abstract: Regioselective and Stereoselective Route to N2‐β‐Tetrazolyl Unnatural Nucleosides via SN2 Reaction at the Anomeric Center of Hoffer′s Chlorosugar.
Authors: Bag Subhendu Sekhar , Talukdar Sangita , Anjali S. J. 
Published: July 2016

Abstract12 N2‐β‐Tetrazolyl unnatural nucleosides of type (III)/(IV) are prepared via a SN2 regioselective and stereoselective reaction; only one of the four possible isomers is formed.
ChemInform Abstract: Norneolignans from the Roots of Clitoria ternatea L.
Authors: Vasisht Karan , Dhobi Mahaveer , Khullar Sadhika , Mandal Sanjay K. , Karan Maninder 
Published: July 2016

AbstractThree new norneolignans, the clitorienolactones A—C along with a known triterpenoid, taraxerol, are isolated from the roots of Clitoria ternatea L.
ChemInform Abstract: Harnessing the Versatility of Continuous‐Flow Processes: Selective and Efficient Reactions
Authors: Mandity Istvan M. , Oetvoes Sandor B. , Szolosi Gyoergy , Fueloep Ferenc 
Published: July 2016

AbstractReview: [such as (stereoselective) hydrogenations, deuterations, the copper‐catalyzed synthesis of triazoles and aromatic azo compounds, organocatalysis, and peptide syntheses; 79 refs.
Rod‐cone crossover connectome of mammalian bipolar cells
Authors: Lauritzen J. Scott , Sigulinsky Crystal L. , Anderson James R. , Kalloniatis Michael , Nelson Noah T. , Emrich Daniel P. , Rapp Christopher , McCarthy Nicholas , Kerzner Ethan , Meyer Miriah , Jones Bryan W. , Marc Robert E. 
Published: July 2016

AbstractThe basis of cross‐suppression between rod and cone channels has long been an enigma. Using rabbit retinal connectome RC1, we show that all cone bipolar cell (BC) classes inhibit rod BCs via amacrine cell (AC) motifs (C1–6); that all cone BC classes are themselves inhibited by AC motifs (R1–5, R25) driven by rod BCs. A sparse symmetric AC motif (CR) is presynaptic and postsynaptic to both rod and cone BCs. ON cone BCs of all classes drive inhibition of rod BCs via motif C1 wide‐field GABAergic ACs (γACs) and motif C2 narrow field glycinergic ON ACs (GACs). Each rod BC receives ≈10 crossover AC synapses and each ON cone BC can target ≈10 or more rod BCs via separate AC processes. OFF cone BCs mediate monosynaptic inhibition of rod BCs via motif C3 driven by OFF γACs and GACs and disynaptic inhibition via motifs C4 and C5 driven by OFF wide‐field γACs and narrow‐field GACs, respectively. Motifs C4 and C5 form halos of 60–100 inhibitory synapses on proximal dendrites of AI γACs. Rod BCs inhibit surrounding arrays of cone BCs through AII GAC networks that access ON and OFF cone BC patches via motifs R1, R2, R4, R5 and a unique ON AC motif R3 that collects rod BC inputs and targets ON cone BCs. Crossover synapses for motifs C1, C4, C5, and R3 are 3–4× larger than typical feedback synapses, which may be a signature for synaptic winner‐take‐all switches. J. Comp. Neurol. 527:87–116, 2019. © 2016 The Authors The Journal of Comparative Neurology Published by Wiley Periodicals, Inc.