bluuebunny/crossref_metadata_2025_split huggingface dataset:
Steering through the storm: Environmental uncertainty and delivery performance
Authors: Ignatius Joshua , Li Rui , Yin Yunqiang , Jia Kunze 
Published: September 2024

AbstractWe investigate the impact of Typhoon Lekima, a source of environmental uncertainty, on delivery performance, utilizing data from RiRiShun Logistics. We apply a staggered difference‐in‐differences model across low‐complexity and high‐complexity supply chains. The analysis uncovers distinct dynamics throughout the typhoon's forecast, active, and recovery phases. Notably, the active phase experiences less disruption in delivery performance compared to the forecast phase, owing to RiRiShun's wait‐and‐see policy. This approach leads to order accumulation but subsequently enables more effective resource allocation. In the recovery phase, high‐complexity supply chains demonstrate significant improvements, surpassing pre‐disaster performance levels. The study further emphasizes the critical role of two response mechanisms in managing high‐complexity supply chains. Increasing throughput efficiencies at destination centers and implementing transfer centers prove effective in enhancing delivery performance during both the forecast and active phases. However, the simultaneous application of these response mechanisms during the forecast phase unexpectedly reduces performance.
Supplementation with carnosine, a food‐derived bioactive dipeptide, alleviates dexamethasone‐induced oxidative stress and bone impairment via the NRF2 signaling pathway
Authors: Li Xi‐you , Gu Xiao‐yuan , Li Xiao‐min , Yan Jian‐gang , Mao Xin‐liang , Yu Qin , Du Yu‐lan , Kurihara Hiroshi , Yan Chang‐Yu , Li Wei‐xi 
Published: September 2024

AbstractBACKGROUNDCarnosine, a natural bioactive dipeptide derived from meat muscle, possesses strong antioxidant properties. Dexamethasone, widely employed for treating various inflammatory diseases, raises concerns regarding its detrimental effects on bone health. This study aimed to investigate the protective effects of carnosine against dexamethasone‐induced oxidative stress and bone impairment, along with its underlying mechanisms, utilizing chick embryos and a zebrafish model in vivo, as well as MC3T3‐E1 cells in vitro.RESULTSOur findings revealed that carnosine effectively mitigated bone injury in dexamethasone‐exposed chick embryos, accompanied by reduced oxidative stress. Further investigation demonstrated that carnosine alleviated impaired osteoblastic differentiation in MC3T3‐E1 cells and zebrafish by suppressing the excessive production of reactive oxygen species (ROS) and enhancing the activity of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GPX). Moreover, mechanistic studies elucidated that carnosine promoted the expression and nuclear translocation of nuclear factor erythroid 2‐related factor 2 (NRF2), thereby facilitating the transcription of its downstream antioxidant response elements, including heme oxyense‐1 (HO‐1), glutamate cysteine ligase modifier (GCLM), and glutamate cysteine ligase catalytic (GCLC) to counteract dexamethasone‐induced oxidative stress.CONCLUSIONOverall, this study underscores the potential therapeutic efficacy of carnosine in mitigating oxidative stress and bone damage induced by dexamethasone exposure, shedding light on its underlying mechanism of action by activating the NRF2 signaling pathway. © 2024 Society of Chemical Industry.
Prognostic Significance of Human Papillomavirus Genotypes in Oropharyngeal Squamous Cell Carcinoma
Authors: Costantino Andrea , Magnuson Jeffery Scott , Alamoudi Uthman , Haughey Bruce 
Published: September 2024

ObjectivesThe prognostic significance of human papillomavirus (HPV) genotypes in oropharyngeal squamous cell carcinoma (OPSCC) has garnered considerable attention due to the increasing reliance on HPV status for clinical decision‐making. This study aimed to compare the survival outcomes associated with different HPV genotypes in patients with OPSCC relative to HPV‐negative tumors, providing insights into the potential implications for treatment de‐intensification strategies.MethodsPatients diagnosed with invasive OPSCC were included from the National Cancer Database (NCDB). Patients were stratified based on HPV status and genotype, with HPV‐negative tumors serving as the reference group. Multivariable Cox regression analysis was performed to assess the independent prognostic value of different HPV genotypes.ResultsTh majority of patient were classified as HPV‐positive (N = 17,358, 70.0%), with HPV 16 being the most common genotype (N = 15410/17358, 88.8%) compared with other high‐risk (N = 1217/17,358, 7.0%) and low‐risk (N = 731/17,358, 4.2%) HPV genotypes. A significantly lower risk of death was measured for all HPV‐positive compared with HPV‐negative tumors (HPV 16: adjusted HR 0.51; 95% CI: 0.49–0.54; other high‐risk HPV: adjusted HR 0.56; 95% CI: 0.49–0.63; low‐risk HPV: adjusted HR 0.59; 95% CI: 0.50–0.68; p < 0.001).ConclusionThis study highlights the significant prognostic value of HPV genotypes in OPSCC, underscoring the superior survival outcomes of HPV‐positive tumors across all genotypes compared with HPV‐negative tumors. Detailed HPV subtype analysis can inform better treatment decisions and support de‐intensification strategies for patients with low‐risk genotypes.Level of Evidence3 Laryngoscope, 135:695–704, 2025
Flexible, Electrochemical Skin‐Like Platform for Inflammatory Biomarker Monitoring
Authors: Lourenço Carolina , Moreira Felismina , Igreja Rui , Martins Gabriela 
Published: September 2024

AbstractAddressing global challenges in wound management has greatly encouraged the emergence of home diagnosis and monitoring devices. This technological shift has accelerated the development of new skin patch sensors for continuous health monitoring. A key requirement is the creation of flexible platforms capable of mimicking human skin features. Here, for the first time, an innovative, highly adaptable electrochemical biosensor with molecularly imprinted polymers (MIPs) is customized for the detection of the inflammatory biomarker interleukin‐6 (IL‐6). The 3‐electrode gold pattern is geometrically standardized onto a 6 µm thick polyimide flexible membrane, an optically transparent, and biocompatible polymeric substrate. Subsequently, a biomimetic sensing layer specifically designed for the detection of IL‐6 target is produced on these transducers. The obtained MIP biosensor shows a good linear response within the concentration range 50 pg mL−1‐50 ng mL−1, with a low limit of detection (8 pg mL−1). X‐ray photoelectron spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy characterizations confirm the modifications of the flexible gold transducer. After optimization, the biosensing device shows remarkable potential in terms of sensitivity, selectivity, and reproducibility. Overall, the integration of a low‐cost electrochemical sensor on biocompatible flexible polymers opens the way for a new generation of monitoring tools with higher accuracy, less invasiveness, and greater patient comfort.
Preparation of Hierarchical Porous Monoliths With High Surface Areas by a Solvent Knitting Strategy
Authors: Zhong Zicheng , Peng Xiaojie , Gao Hui , Hussain Irshad , Wang Xiaoyan , Tan Bien 
Published: September 2024

AbstractHierarchical porous hypercrosslinked monoliths (PolyHIPE‐HCP) with ultrahigh specific surface areas are prepared via a solvent knitting strategy. Compared to previous work, the solvent knitting strategy is carried out in a relatively low air‐controlled atmosphere with gradient heating starting from low temperature while using DCM (Dichloromethane) as both a solvent and a cross‐linker, allowing for a slow and controlled cross‐linking process, thereby achieving a BET surface area ranging from 514 to 728 m2 g−1. Scanning electron microscopy (SEM) shows that the knitting process does not affect the presence of macroporous structure in the PolyHIPE. With the introduction of mesopores and micropores, these hierarchical porous monoliths exhibit significant potential for applications in gas adsorption and water treatment. Hence, a universal, simple and low‐cost method to synthesize polymeric monoliths with hierarchically porous structure and higher surface area is proposed, which has fascinating prospects in industrialization.
Individual curved‐needle interstitial template created using three‐dimensional printing for brachytherapy for distal parauterine tumor recurrence
Authors: Zhang Jie , Luo Chunli , Zhang Wenjun , Yan Junfang , Yu Lang , Qiu Jie 
Published: September 2024

AbstractBackgroundAchieving a clinically acceptable dose distribution with commercial vaginal applicators for brachytherapy of recurrent parauterine tumors is challenging. However, the application of three‐dimensional (3D) printing technology in brachytherapy has been widely acknowledged and can improve clinical treatment outcomes.PurposeThis study aimed to introduce an individual curved‐needle interstitial template (ICIT) created using 3D printing technology for high‐dose‐rate (HDR) brachytherapy with interstitial treatment to provide a clinically feasible approach to distal parauterine and vaginal cuff tumors. The entire workflow, including the design, optimization, and application, is presented.MethodsTen patients with pelvic cancer recurrence were examined at our center. The vaginal topography was filled with gauze strips soaked in developer solution, and images were obtained using computed tomography (CT) and magnetic resonance imaging (MRI). Curved needle paths were designed, and ICITs were 3D‐printed according to the high‐risk clinical target volume (HRCTV) and vaginal filling model. The dose and volume histogram parameters of the HRCTV (V100, V200, D90, and D98) and organs at risk (OARs) (D2cc) were recorded.ResultsAll patients completed interstitial brachytherapy treatment with the 3D‐printed ICIT. One patient experienced vaginal cuff tumor recurrence, and nine patients experienced parametrial tumor recurrence (four on the left and five on the right). We used two to five interstitial needles, and the maximum angle of the curved needle was 40°. No source obstruction events occurred during treatment of these 10 patients. The doses delivered to the targets and OARs of all patients were within the dose limits and based on clinical experience at our center.ConclusionThe ICIT is a treatment option for patients with distal parauterine tumor recurrence. This method addresses the limitations of vaginal intracavitary and standard interstitial applicators. The ICIT has the advantages of biocompatibility, personalization, and magnetic resonance imaging compatibility.
Optimisation of the hammer throw using parameterised synthetic motion kinematics in a multi‐body simulation
Authors: Schmidtchen Fabian , Daniel Christian , Tiedemann Stefan , Woschke Elmar 
Published: September 2024

AbstractHammer throwing is a motorically demanding sport in which the execution of the movement significantly influences the result, that is the throwing distance. There are many approaches for supporting technical training that are based on measurement technology and image capturing. The accelerations and locus curves of the athlete and hammer are recorded and compared. In this article, these methods are supplemented by a multi‐body simulation (MBS) of the hammer throw. The kinematics of the hand movement is described using a parameterized synthetic trajectory. Scalar parameters in the approach allow the trajectory to be modified. With a MBS model of the wire cable and the hammer, the movement of the hammer can be determined by numerical time integration from the hand's trajectory. As a result the final throwing distance after free flight phase can be analyzed. Due to the complex spatial motion of the hammer during the acceleration phase only heuristic methods can be used to optimize the maximum throwing distance. In a final step the optimized movement can be used to improve the athlete's training.
Family strategies for managing childhood cancer: Using traditional and complementary medicine in Southern Egypt
Authors: Farrag Ahmed , Alqudimat Mohammad R. , Hassan Fatma A. A. 
Published: September 2024

AbstractBackground and purposeThe use of traditional and complementary medicine (T&CM) is common in children with cancer globally. We aimed to assess the prevalence, types, reasons, perceived effectiveness, and disclosure rate of T&CM use among children with cancer in Southern Egypt. We also investigated whether T&CM use contributed to delays in initial presentation and treatment.Materials and methodsA cross‐sectional design was utilized. Data were collected via an interviewer‐administered questionnaire. Eligible children and their caregivers at the South Egypt Cancer Institute were invited to participate.ResultsEighty‐six children completed the study (response rate = 86%). T&CM use was reported by 52 (60.5%) patients, with six (11.5%) experienced delayed presentation. The reasons for T&CM use were complementary for 37 (71%) and alternative for 15 (29%) of the participants. The types of T&CM used included herbal (63%), nutritional (33%), witchcraft (29%), and religious (19%) therapies. Approximately 48% of users employed multiple T&CM types. Family members recommended T&CM for 60% of the users. Most patients (65%) perceived T&CM as effective, with 71% initiating its use during the early phases of treatment. Almost all participants (98%) reported that healthcare providers did not inquire about T&CM use. T&CM usage was more prevalent among wealthier families (p = .023). There was no significant relationship between T&CM use and patient gender, diagnosis, residence, or paternal educational level.ConclusionsThe significant utilization of T&CM among children with cancer highlights the need for healthcare providers to engage in open and early discussions with families regarding T&CM use.
Early defibrotide therapy and risk factors for post‐transplant veno‐occlusive disease/sinusoidal obstruction syndrome in childhood
Authors: Goto Hironori , Oba Utako , Ueda Tamaki , Yamamoto Shunsuke , Inoue Masataka , Shimo Yu , Yokoyama Satomi , Takase Yusuke , Kato Wakako , Suenobu Souichi , Ihara Kenji , Koga Yuhki , Ohga Shouichi 
Published: September 2024

AbstractBackgroundVeno‐occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), is a life‐threatening complications of hematopoietic cell transplantation (HCT).MethodsWe studied the impact of early defibrotide (DF) therapy on the outcomes of pediatric patients with VOD/SOS after transplantation, focusing on recent immunotherapies. A total of 111 pediatric patients who underwent HCT for malignant disease between February 2017 and March 2023 at Kyushu University Hospital were included.ResultsAmong 111 patients of less than 20 years of age who underwent HCT for malignancy at a single institution between 2017 and 2023, VOD/SOS occurred in 25 (23%) patients. VOD/SOS developed more frequently in the post‐DF era (2020–2023, n = 58) than in the pre‐DF era (31% vs. 13%, p = .04). The proportion of patients with relapsed/refractory acute lymphoblastic leukemia (ALL) was higher in the post‐DF era than in the pre‐DF era (44% vs. 8%, p = .04). Early DF therapy that was started at two European Society for Blood and Marrow Transplantation diagnostic criteria reduced the severity of VOD/SOS (p < .01) in comparison to non‐early therapy started at less than two criteria. A multivariate analysis indicated that a history of cytokine release syndrome (odds ratio [OR] = 10.4, p = .01) and juvenile myelomonocytic leukemia (OR = 8.98, p = .04), but not an endothelial activation and stress index (EASIX) score of greater than 0.85, were independent risk factors for VOD/SOS.ConclusionsEarly DF therapy improves the severity and survival outcomes of post‐transplant VOD/SOS in children. However, its incidence is increasing in the era of immunotherapy for progressive diseases.
Exploring Turkey's mosaic of novel variants and complex alleles in cystic fibrosis genetics
Authors: Yıldız Ceren Ayça , Selçuk Balcı Merve , Karabulut Şeyda , Başer Zeynep Münteha , Kalyoncu Mine , Metin Çakar Neval , Akkitap Yiğit Müge Merve , Baysal Eda Esra , Özdemircioğlu Fulya , Uzunoğlu Burcu , Taştan Gamze , Ergenekon Pınar , Gökdemir Yasemin , Erdem Eralp Ela , Karakoç Fazilet , Ata Pınar , Karadağ Bülent 
Published: September 2024

AbstractBackgroundsGenetic variants in CF transmembrane conductance regulator (CFTR) gene causes cystic fibrosis (CF), a prevalent autosomal recessive disorder. More than 2000 variants in CFTR have been described as disease causative. This study aims to delineate the genotypic and phenotypic landscape of CF among people with CF (pwCF) followed at the largest CF center in Turkey.MethodsWe conducted a descriptive and retrospective analysis of 481 patients registered with the European CF Society Patient Registry and followed at Marmara University Selim Çöremen CF Center from 2015 onwards. Comprehensive CFTR analysis was utilized for genetic diagnosis. Besides the whole cohort, novel variants and complex alleles were also described.ResultsOur cohort exhibited a broad spectrum of CFTR variants, with 136 different variants detected, indicating substantial genetic diversity. The F508del variant was less prevalent in our cohort compared to US and European averages, which could reflect unique genetic and demographic characteristics of the Turkish population. Additionally, we identified nine novel variants in 12 alleles, which enhances the understanding of CF's genetic complexity in this region, and complex alleles in 32 pwCF.ConclusionOur research underscores the heterogeneity of CFTR variants in Turkey and highlights the necessity for extensive genetic profiling particularly for diverse populations to provide effective personalized treatment strategies. It is crucial to understand the full spectrum of CFTR variants with the advent of CFTR modulators.
A survey of cystic fibrosis physicians' views on lung transplant referral in the era of elexacaftor/tezacaftor/ivacaftor
Authors: Burdis Nora , Milinic Tijana , Bartlett Lauren E. , Goss Louisa , Tallarico Erin , Boyle Abigail , Thaxton Abigail , Turner Grant A. , Benvenuto Luke J. , Faro Albert , Goss Christopher H. , Kapnadak Siddhartha G. , Ramos Kathleen J. 
Published: September 2024

AbstractRationaleIn 2015, a survey of cystic fibrosis (CF) physicians showed significant gaps in lung transplant (LTx) referral knowledge. Subsequently, LTx referral guidelines for people with CF were published, and elexacaftor/tezacaftor/ivacaftor (ETI) became available for >80% of people in the United States (US). We sought to assess physicians’ LTx referral knowledge and self‐reported referral practices.MethodsCF center directors in the US were surveyed about LTx. Questions addressed transplant referral indications, contraindications, testing, and the impact of ETI on referral timing. Thematic analysis was used to assess responses to open‐ended questions.ResultsThere were 110/309 (36%) responses. Respondents identified several referral indications, including rapid decline in FEV1 (93%), recurrent hemoptysis (80%), hypoxemia (79%), and pulmonary hypertension (75%). Over 70% of respondents reported using oximetry, echocardiogram, and blood gas to assess disease severity. Respondents were more likely to find early LTx discussions useful for patients not on modulators versus on modulators (87% vs. 63%, p < .005). Most respondents (66%) reported delaying LTx referral for some patients with FEV1 30%–40% who met criteria, while 26% had delayed referral for patients with FEV1 < 30%. Uncertainty regarding optimal LTx referral timing for patients on ETI was a prominent theme of the qualitative analysis.ConclusionsWhile physician knowledge about LTx referral indications appears improved since the CF referral guidelines were published, uncertainty about referral timing is pervasive, and the guidelines will need to be updated as more data become available about the long‐term effectiveness of ETI in advanced lung disease.
Diagnostic approach to the etiology of recurrent pneumonia in children
Authors: Özçelik Taha , Can Oksay Sinem , Girit Saniye 
Published: September 2024

AbstractBackgroundRecurrent pneumonia (RP) accounts for 7.7%–9% of childhood pneumonia. Identifying the cause of RP is crucial for infection control and reducing mortality and morbidity. This study aimed to investigate the etiology, risk factors, and diagnostic procedures of RP based on the literature using a diagnostic algorithm.MethodsOur study included RP patients aged 0–18 years who were followed up as outpatients or inpatients between 2018 and 2021. Patients were analyzed retrospectively using the national health database. Patients with RP were identified by ICD diagnosis codes. Etiology and risk factors were determined based on the occurrence of RP in the same or different areas.ResultsThe rate of RP was found to be 14.4% among the cases of recurrent lower respiratory tract infection. Of these, 27.6% occurred in the same area and 72.4% in different areas. The underlying etiology was identified in 224 of 250 RP patients (89.6%). RP in different areas was mainly due to neuromuscular diseases, whereas asthma, right middle lobe syndrome, and congenital lung or airway structural disease were common causes of RP in the same area. Malnutrition, passive smoke exposure, and prematurity were common risk factors in both groups.ConclusionsSystematic etiological investigations should take into account the characteristics of the patient population and geographical region. The use of diagnostic algorithms based on recurrence in the same or different areas is particularly beneficial. Whether asthma is causally related to RP episodes or is a coincidental association due to inadequate differential diagnosis remains unclear.
O‐GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co‐chaperone
Authors: Javed Afraah , Johnson Oleta T. , Balana Aaron T. , Volk Regan F. , Langen Andreas , Ahn Benjamin S. , Zaro Balyn W. , Gestwicki Jason E. , Pratt Matthew R. 
Published: September 2024

AbstractAlmost all types of cellular stress induce post‐translational O‐GlcNAc modifications of proteins, and this increase promotes cell survival. We previously demonstrated that O‐GlcNAc on certain small heat shock proteins (sHSPs), including HSP27, directly increases their chaperone activity as one potential protective mechanism. Here, we furthered our use of synthetic proteins to prepare biotinylated sHSPs and show that O‐GlcNAc modification of HSP27 also changes how it interacts within the sHSP system and the broader HSP network. Specifically, we show that O‐GlcNAc modified HSP27 binds more strongly to the co‐chaperone protein BAG3, which then promotes refolding of a model substrate by HSP70. We use proteomics to identify other potential HSP27 interactions that are changed by O‐GlcNAc, including one that we confirm with another sHSP, αB‐crystallin. These findings add additional evidence for O‐GlcNAc as a switch for regulating protein–protein interactions and for modifications of chaperones as one mechanism by which O‐GlcNAc protects against protein aggregation.