bluuebunny/crossref_metadata_2025_split huggingface dataset:
A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes
Authors: Fukaya Makiko , Brorsson Caroline A. , Meyerovich Kira , Catrysse Leen , Delaroche Diane , Vanzela Emerielle C. , Ortis Fernanda , Beyaert Rudi , Nielsen Lotte B. , Andersen Marie L. , Mortensen Henrik B. , Pociot Flemming , van Loo Geert , Størling Joachim , Cardozo Alessandra K. 
Published: December 2015

AbstractActivation of the transcription factor nuclear factor kappa B (NFkB) contributes to β-cell death in type 1 diabetes (T1D). Genome-wide association studies have identified the gene TNF-induced protein 3 (TNFAIP3), encoding for the zinc finger protein A20, as a susceptibility locus for T1D. A20 restricts NF-κB signaling and has strong antiapoptotic activities in β-cells. Although the role of A20 on NF-κB inhibition is well characterized, its other antiapoptotic functions are largely unknown. By studying INS-1E cells and rat dispersed islet cells knocked down or overexpressing A20 and islets isolated from the β-cell-specific A20 knockout mice, we presently demonstrate that A20 has broader effects in β-cells that are not restricted to inhibition of NF-κB. These involves, suppression of the proapoptotic mitogen-activated protein kinase c-Jun N-terminal kinase (JNK), activation of survival signaling via v-akt murine thymoma viral oncogene homolog (Akt) and consequently inhibition of the intrinsic apoptotic pathway. Finally, in a cohort of T1D children, we observed that the risk allele of the rs2327832 single nucleotide polymorphism of TNFAIP3 predicted lower C-peptide and higher hemoglobin A1c (HbA1c) levels 12 months after disease onset, indicating reduced residual β-cell function and impaired glycemic control. In conclusion, our results indicate a critical role for A20 in the regulation of β-cell survival and unveil novel mechanisms by which A20 controls β-cell fate. Moreover, we identify the single nucleotide polymorphism rs2327832 of TNFAIP3 as a possible prognostic marker for diabetes outcome in children with T1D.
Hindsight/RREB-1 functions in both the specification and differentiation of stem cells in the adult midgut ofDrosophila
Authors: Baechler Brittany L. , McKnight Cameron , Pruchnicki Porsha C. , Biro Nicole A. , Reed Bruce H. 
Published: December 2015

ABSTRACTThe adult Drosophila midgut is established during the larval/pupal transition from undifferentiated cells known as adult midgut precursors (AMPs). Four fundamental cell types are found in the adult midgut epithelium: undifferentiated intestinal stem cells (ISCs) and their committed daughter cells, enteroblasts (EBs), plus enterocytes (ECs) and enteroendocrine cells (EEs). Using the Drosophila posterior midgut as a model, we have studied the function of the transcription factor Hindsight (Hnt)/RREB-1 and its relationship to the Notch and Egfr signaling pathways. We show that hnt is required for EC differentiation in the context of ISC-to-EC differentiation, but not in the context of AMP-to-EC differentiation. In addition, we show that hnt is required for the establishment of viable or functional ISCs. Overall, our studies introduce hnt as a key factor in the regulation of both the developing and the mature adult midgut. We suggest that the nature of these contextual differences can be explained through the interaction of hnt with multiple signaling pathways.
Intraoperative and delayed wound approximation in closure of skin defects in different areas
Authors: Aboelatta Y. A. , Elshahm A. , Saleh M. A. , Kamel I.H. , Aly H. M. 
Published: December 2015

Objective: Wound approximation device is an interesting reconstructive option but not well popularised. In this study we present a simple device that can be used for immediate or delayed closure of large dermal wounds in different anatomical areas. Method: Patients with acute and chronic wounds were recruited and underwent immediate intra-operative wound approximation and/or delayed wound approximation, with a home-made wound approximation device. Results: Approximation time in the immediate closure group ranged from 20–140 minutes. Satisfactory scars were obtained in 19 patients (76%) and adherent scars developed in 6 patients. Delayed wound approximation was used successfully in closure of 9 defects. Conclusion: This simple dermal wound approximation device can be used intraoperatively to successfully close large difficult wounds, located on the trunk and thigh, with minimal complications. The device can also be used to approximate delayed wounds located in regions where closure is particularly problematic, like the lower leg, foot, and scalp. Some modifications of the device are needed to improve its safety and efficacy. Wound tension is detrimental to adequate wound healing and tensile strength, another basic principle that should not be overlooked to avoid wound dehiscence. Wound approximation is adding to reconstructive options, not replacing them, and they must always be considered.
Further seductions: ‘Mrs. Robinson’, post-Graduate
Authors: Godsall Jonathan 
Published: December 2015

Abstract
This article considers Simon and Garfunkel’s ‘Mrs. Robinson’ in its original context of The Graduate (Nichols, 1967) in relation to its composition, lyrical content and narrative role. The song’s later use in other films is then examined, with consideration of issues of intention and reception in regard to evocation of The Graduate, and of the part that visual and other elements play in this alongside music. ‘Mrs. Robinson’ is seemingly universally employed as a deliberate nod to Nichols’s film, but a variety of contexts for and manners of this can be identified, in part using Serge Lacasse’s (2000) concepts of ‘autosonic’ and ‘allosonic’ quotation (where the former is the quotation of recorded sound, and the latter that of abstract musical structure, realized through new sonic means). The article argues that these later uses of ‘Mrs. Robinson’ have contributed to a re-inscription of the song’s signification in culture more broadly; much as Benjamin is seduced – led astray – by Mrs Robinson in The Graduate, we ourselves have now been seduced into new and arguably false interpretations of her musical namesake.
Does the song really remain the same? ‘The Windmills of Your Mind’ as narrational vehicle in The Thomas Crown Affair (1968 and 1999)
Authors: Bennett Marie 
Published: December 2015

Abstract
Despite the charisma of its stars, Steve McQueen and Faye Dunaway, the original version of The Thomas Crown Affair (Jewison,1968) is not thought of as a classic film of its era. As a consequence, it is generally best remembered less for its plot than for its use of novel split screen images, the infamous chess game scene, and its Oscar-winning song, ‘The Windmills of Your Mind’, performed by Noel Harrison. The song is heard during the film’s opening titles, but also features as non-diegetic underscore during a scene in which Crown (McQueen) flies a glider part way through the film. Various scholars suggest that ‘The Windmills of Your Mind’s inclusion is as an interpolated song, i.e., that it has no particular connection to the film’s storyline. In contrast, I argue that the song’s music and lyrics do serve a narrative function, and that my claim is reinforced through its inclusion in the 1999 remake, which features Pierce Brosnan and Rene Russo in the leading roles. On this occasion, the song appears to be included as an homage to the original version; it is performed by another Englishman, Sting, and it is heard over the closing credits as an evocative reminder of the earlier film.
The relationship between secondary school grade point average scores and musical interest in Turkey
Authors: Soycan Merve , Göher Vural Feyzan 
Published: December 2015

<p>In Turkish educational system, students’ secondary school grade point average (GPA) scores constitute the basic criteria in determining the high schools they will next attend. Students, who start their high school careers based on this grade, receive their education together with peers who have similar GPA scores. In these pivotal years which play a significant role in developing character, teenagers not only affect each other through interaction, but also shape their likes and dislikes collectively during this high school period. Music interest in students is also shaped during this process. <em> </em>This descriptive study has been conducted at nine high schools in central Konya. The sample group includes a total of 626 students, 195 of whom are from three high schools with high GPA scores, 193 from three high schools with average GPA scores, and 238 from three high schools with low GPA scores. The results of the study reveal not only certain similarities between the student groups, but also significant difference between the groups in terms of the will to play a musical instrument, the music genres the students prefer to listen, singers and bands the students follow, and whether or not to choose music as a career path.</p>
A Fredholm alternative for quasilinear elliptic equations with right-hand side measure
Authors: Colturato Michele , Degiovanni Marco 
Published: December 2015

Abstract
We consider a quasilinear elliptic equation with right-hand side
measure, which does not satisfy the usual coercivity assumption.
We prove an existence result in the line of the Fredholm alternative. For this purpose we develop a variant of degree theory suited to this setting.
Earth rotation and geodynamics
Authors: Bogusz Janusz , Brzezinski Aleksander , Kosek Wieslaw , Nastula Jolanta 
Published: December 2015

Abstract
This paper presents the summary of research activities carried out in Poland in 2011-2014 in the field of Earth rotation and geodynamics by several Polish research institutions. It contains a summary of works on Earth rotation, including evaluation and prediction of its parameters and analysis of the related excitation data as well as research on associated geodynamic phenomena such as geocentre motion, global sea level change and hydrological processes. The second part of the paper deals with monitoring of geodynamic phenomena. It contains analysis of geodynamic networks of local, and regional scale using space (GNSS and SLR) techniques, Earth tides monitoring with gravimeters and water-tube hydrostatic clinometer, and the determination of secular variation of the Earth’ magnetic field.
Positioning and applications
Authors: Rogowski Jerzy B. , Wielgosz Pawel 
Published: December 2015

Abstract
The paper presents national report of Poland for IAG on positioning and applications. The selected research presented was carried out at leading Polish research institutions and concern precise multi-GNSS satellite positioning - relative and absolute - and also GNSS-based ionosphere and troposphere modelling and studies. The research resulted in noticeable advancements in these subjects confirmed by the development of new algorithms and methods. New and improved methods of precise GNSS positioning were developed, and also GNSS metrology was studied. New advanced troposphere models were presented and tested. In particular, these models allowed testing IPW variability on regional and global scales. Also, new regional ionosphere monitoring web-based services were developed and launched.
Generating Interactive Prototypes from Query Annotated Discourse Models
Authors: Kis Filip , Bogdan Cristian 
Published: December 2015

Abstract
Model Based User Interface Development offers the possibility to design User Interfaces without being concerned about the underlying implementation. This is achieved by devising models at a high level of abstraction, thus creating the potential for involving users or domain experts to achieve a user-centered design process. Obtaining a running interactive application from such models usually requires several model transformations. One of the current problems is that while a user interface is generated after these transformations, other parts of the interactive system such as the application logic need to pre-exist or they must be written manually before the interface can be tested in a realistic scenario. This leaves the domain experts dependent on programmers and increases the time between iterations. In this paper we work with Query Annotations, which were previously used only for modeling at low levels and for generating fully functional interfaces, and we aim to generalize them for the high-level modeling approach called Discourse Modeling. The direct expected benefit of this generalization is the possibility to generate complete, readily testable interactive prototypes, rather than just their user interfaces. In addition, Query Annotations can serve as the mapping between the various levels of abstraction and bring to the domain experts a better understanding of the transformation process, as well as the possibility to modify the interfaces and models directly.
Multiple Virus Infections and the Characteristics of Chronic Bee Paralysis Virus in Diseased Honey Bees (Apis Mellifera L.) in China
Authors: Wu Yan Y. , Jia Hui R. , Wang Qiang , Dai Ping L. , Diao Qing Y. , Xu Shu F. , Wang Xing , Zhou Ting 
Published: December 2015

Abstract
China has the largest number of managed honey bee colonies globally, but there is currently no data on viral infection in diseased A. mellifera L. colonies in China. In particular, there is a lack of data on chronic bee paralysis virus (CBPV) in Chinese honey bee colonies. Consequently, the present study investigated the occurrence and frequency of several widespread honey bee viruses in diseased Chinese apiaries, and we used the reverse transcription-polymerase chain reaction (RT-PCR) assay. Described was the relationship between the presence of CBPV and diseased colonies (with at least one of the following symptoms: depopulation, paralysis, dark body colorings and hairless, or a mass of dead bees on the ground surrounding the beehives). Phylogenetic analyses of CBPV were employed. The prevalence of multiple infections of honey bee viruses in diseased Chinese apiaries was 100%, and the prevalence of infections with even five and six viruses were higher than expected. The incidence of CBPV in diseased colonies was significantly higher than that in apparently healthy colonies in Chinese A. mellifera aparies, and CBPV isolates from China can be separated into Chinese-Japanese clade 1 and 2. The results indicate that beekeeping in China may be threatened by colony decline due to the high prevalence of multiple viruses with CBPV.
On the reconstruction of obstacles and of rigid bodies immersed in a viscous incompressible fluid
Authors: San Martín Jorge , Schwindt Erica L. , Takahashi Takéo 
Published: December 2015

Abstract
We consider the geometrical inverse problem consisting in recovering an unknown obstacle in a viscous incompressible fluid by measurements of the Cauchy force on the exterior boundary. We deal with the case where the fluid equations are the nonstationary Stokes system and using the enclosure method, we can recover the convex hull of the obstacle and the distance from a point to the obstacle. With the same method, we can obtain the same result in the case of a linear fluid-structure system composed by a rigid body and a viscous incompressible fluid. We also tackle the corresponding nonlinear systems: the Navier–Stokes system and a fluid-structure system with free boundary. Using complex spherical waves, we obtain some partial information on the distance from a point to the obstacle.
Heuristics for NP-hard optimization problems - simpler is better!?
Authors: Žerovnik Janez 
Published: December 2015

Abstract
We provide several examples showing that local search, the most basic metaheuristics, may be a very competitive choice for solving computationally hard optimization problems. In addition, generation of starting solutions by greedy heuristics should be at least considered as one of very natural possibilities. In this critical survey, selected examples discussed include the traveling salesman, the resource-constrained project scheduling, the channel assignment, and computation of bounds for the Shannon capacity.
Tourism sector, Travel agencies, and Transport Suppliers: Comparison of Different Estimators in the Structural Equation Modeling
Authors: Kovačić Nataša , Topolšek Darja , Dragan Dejan 
Published: December 2015

Abstract
The paper addresses the effect of external integration (EI) with transport suppliers on the efficiency of travel agencies in the tourism sector supply chains. The main aim is the comparison of different estimation methods used in the structural equation modeling (SEM), applied to discover possible relationships between EIs and efficiencies. The latter are calculated by the means of data envelopment analysis (DEA). While designing the structural equation model, the exploratory and confirmatory factor analyses are also used as preliminary statistical procedures. For the estimation of parameters of SEM model, three different methods are explained, analyzed and compared: maximum likelihood (ML) method, Bayesian Markov Chain Monte Carlo (BMCMC) method, and unweighted least squares (ULS) method. The study reveals that all estimation methods calculate comparable estimated parameters. The results also give an evidence of good model fit performance. Besides, the research confirms that the amplified external integration with transport providers leads to increased efficiency of travel agencies, which might be a very interesting finding for the operational management.
Molecular characterization and pathogenicity of Erwinia spp. associated with pineapple [Ananas comosus (L.) Merr.] and papaya (Carica papaya L.)
Authors: Ramachandran Kogeethavani , Manaf Uyub Abdul , Zakaria Latiffah 
Published: December 2015

AbstractThe Erwinia species are well-known pathogens of economic importance in Malaysia causing serious damage to high-value fruit crops that include pineapple [Ananas comosus (L.) Merr.] and papaya (Carica papaya L.).The 16S rRNA sequence using eubacteria fD1 and rP2 primers, identified two bacteria species; Dickeya zeae from pineapple heart rot, and Erwinia mallotivora from papaya dieback. Phylogenetic analysis based on the neighbor-joining method indicated that all the bacterial isolates clustered in their own taxa and formed monophyletic clades. From the pathogenicity test, all isolates of D. zeae and E. mallotivora showed pathogenic reactions on their respective host plants. Genetic variability of these isolates was assessed using repetitive sequence-based PCR (rep-PCR) fingerprinting. The results indicated interspecies, and intraspecies variation in both species’ isolates. There were more polymorphic bands shown by rep-PCR fingerprints than enterobacterial repetitive intergenic consensus (ERIC) and BOX- PCRs, however both species’ isolates produced distinguishable banding patterns. Unweighted pair-group method with arithmetic averages (UPGMA) cluster analysis indicated that all Dickeya and Erwinia isolates from the same species were grouped in the same main cluster. Similarity among the isolates ranged from 77 to 99%. Sequencing of 16S rRNA using eubacteria fD1 and rP2 primers, and rep-PCR fingerprinting revealed diversity among Dickeya and Erwinia isolates. But this method appears to be reliable for discriminating isolates from pineapple heart rot and papaya dieback.
Valerian (Valeriana officinalis L.) tolerance to some post-emergence herbicides
Authors: Monjezi Nadia , Razmjo Jamshid , Karimmojeni Hassan 
Published: December 2015

AbstractValerian (Valeriana officinalis L.) is a medicinal plant, but its cultivation is restricted by weed competition. Therefore, three rates (0.75X, 1X, and 1.25X, where X is equal to the recommended dose of haloxyfop-R (methyl ester), sethoxydim, oxadiargyl, bentazon, oxadiazon, and oxyfluorfen) were applied at the 3-4 leaf stages to valerian plants. This application was done to select the herbicide type and rate for post-controlling broadleaf and grasses weeds in this species. Herbicide injury, Soil-Plant Analyses Development (SPAD) reading, number of leaves per plant, stem diameter, and fresh and dry weights were determined 10, 20, and 30 days after herbicide application. Oxyfluorfen application caused the most herbicide injury followed by bentazon. Injury increased as the rate and the days after application increased. Oxadiazon only caused significant damage 30 days after application under all three rates. Other treatments showed no marked injuries under any rate or date after application, as compared with the control. Effects on other measured traits depended on the trait, herbicide, and herbicide rate. The highest SPAD, leaf number, shoot diameter, fresh weight and dry weight, was recorded under application of 30 mg a.i. ∙ kg-1soil oxadiargyl and 90 mg a.i. ∙ kg-1soil oxadiazon, 81 mg a.i. ∙ kg-1soil haloxyfop-R, 37.5 mg a.i. ∙ kg-1soil oxadiargyl, 22.5 mg a.i. ∙ kg-1soil oxadiargyl, 81 mg a.i. ∙ kg-1soil haloxyfop-R, and 81 mg a.i. ∙ kg-1soil haloxyfop-R, respectively. To sum up, the results showed that sethoxydim, oxadiargyl, and haloxyfop-R produced no significant symptoms of phytotoxicity or reduction of measured traits. This means that oxadiargyl, haloxyfop-R, and sethoxydim may be used safely for weed control of valerian at the rates used in this experiment under similar conditions.
The Effects of L-Carnitine in Budd-Chiari Syndrome in a Domestic Cat
Authors: Öztürk Aliye Sağkan , Altuğ Nuri , Köse Serkan İrfan , Öztürk Oktay Hasan 
Published: December 2015

Abstract
This paper describes a thrombosis in the vena cava caudalis of a 15 year-old cat with ascites. Trauma and eventually feline enteric corona virus infection in the cat were not detected. In the intrahepatic region, a blockage of vena cava caudalis was brought to light by ultrasonographic imaging. An aspirate of abdominal fluid revealed modified transudate. Liver enzyme levels were increased in the serum sample of the cat. The levels of total oxidant status (TOS) and total antioxidant status (TAS) were elevated in the peritoneal fluid. Liver protection diet with L-carnitine, diuretic therapy and antimicrobial drugs were administrated for treatment of the cat. During the continuous treatment, the amount of abdominal fluid decreased, but never completely absorbed. L-carnitine was administered to the cat during the time of treatment, and subsequently the levels of liver enzymes decreased. However, the cat died because of recurrent ascites and persistent thrombosis. In conclusion, ultrasonographic examination was very reliable, non-invasive and highly useful diagnostic method for BCS and L-carnitine has crucial effects on the quality of life, energy metabolism and liver enzyme levels. However, the blockage of the vena cava caudalis could not completely respond to medical treatment and thrombosis should be eliminated by surgical intervention.
On Monoids of Injective Partial Cofinite Selfmaps
Authors: Gutik Oleg , Repovš Dušan 
Published: December 2015

Abstract
We study the semigroup Icf
λ of injective partial cofinite selfmaps of an infinite cardinal λ. We show that Icf
λ is a bisimple inverse semigroup and each chain of idempotents in Icf
λ is contained in a bicyclic subsemigroup of Icf
λ , we describe the Green relations on Icf
λ and we prove that every non-trivial congruence on Icf
λ is a group congruence. Also, we describe the structure of the quotient semigroup Icf
λ /σ, where σ is the least group congruence on Icf
λ.
Spectra and Fine Spectra of Lower Triangular Double-Band Matrices as Operators on Lp (1 ≤ p < ∞)
Authors: Akhmedov Ali M. , El-Shabrawy Saad R. 
Published: December 2015

Abstract
Let Δa,b denote an infinite lower triangular double-band matrix. In this paper, the spectrum, the point spectrum, the continuous spectrum and the residual spectrum of the matrix Δa,b as a linear operator on the sequence space lp, where 1 ≤ p < ∞ are characterized completely