bluuebunny/crossref_metadata_2025_split huggingface dataset:
SOLITARY RETINAL CAPILLARY HEMANGIOMA IN A PATIENT WITH BILATERAL CHORIORETINAL COLOBOMA
Authors: Lasave Andres F. , Deromedis Pablo 
Published: March 2017

Purpose:
To report a case showing a very rare association of chorioretinal coloboma and retinal capillary hemangioma in a previously healthy patient.

Methods:
Observational case report.

Results:
A 21-year-old woman presented at our clinic for vision screening. She had a history of bilateral chorioretinal coloboma with amblyopia in her left eye. Her best-corrected visual acuity was 20/25 in her right eye and 20/200 in her left eye. On slit-lamp examination, iris coloboma was observed in the left eye. Fundus evaluation showed inferior chorioretinal coloboma in both eyes, and an elevated, round, and orange-red retinal lesion with feeder vessels localized in the midperipheral region of the right eye. The patient was diagnosed as having solitary retinal capillary hemangioma and underwent argon laser therapy for treating the tumoral lesion. Diagnostic studies were negative for von Hippel–Lindau disease. This is the first reported case of solitary retinal capillary hemangioma associated with bilateral chorioretinal coloboma.

Conclusion:
Chorioretinal coloboma is a congenital defect of the eye caused by improper closure of the embryonic fissure. Retinal capillary hemangioma is a vascular retinal tumor that may occur sporadically or as part of the von Hippel–Lindau syndrome. We report a rare association of chorioretinal coloboma and retinal capillary hemangioma in a previously healthy patient.
Endocan Overexpression in Pterygium
Authors: Kiliç Raşit , Kurt Ali , Tad Murat , Taşdemir Sedat 
Published: March 2017

Purpose:
The aim of this study was to evaluate the possible role of endocan in the pathogenesis of pterygium.

Methods:
The study was conducted on 33 patients with primary pterygium and 20 control subjects with normal bulbar conjunctiva. Patients with pterygium were graded into 3 groups as atrophic, fleshy, and intermediate, according to the Tan classification. Primary nasal pterygia and normal bulbar conjunctivas were surgically removed. Endocan expression was immunohistochemically investigated.

Results:
Endocan expression in epithelial and endothelial cells was statistically significantly higher in pterygium tissues than control tissues (P = 0.001). No significant correlation was observed between pterygium classification groups and endocan expression in both epithelial and endothelial cells (P > 0.05).

Conclusions:
The results suggest that endocan may have a role in the pathogenesis of pterygium.
Diagnostic challenges, the evaluation of antibiotic allergy
Authors: O’Keefe Andrew , Ben-Shoshan Moshe 
Published: March 2017

Purpose of review
Antibiotic allergy is commonly reported and often challenging to evaluate. This review highlights recent developments in our understanding of antibiotic allergy, primarily surrounding evaluation, and diagnosis of antibiotic allergy. We provide historical context to establish a framework, lending relevance to the latest studies.

Recent findings
Clinicians have typically employed skin testing as a first step in the diagnosis of drug allergy, reserving drug provocation challenge, the gold standard for diagnosis, for those with negative skin tests. Although skin tests have a good negative predictive value, the positive predictive value has never been established. An increasing amount of research is demonstrating that drug provocation challenge is well tolerated as the initial evaluation in patients with non-life-threatening reactions to antibiotics. This research also calls into question the value of skin testing in these patients.

Summary
Skin testing has long been used as the initial investigation in the diagnosis of drug allergy. New research supports that this may not be necessary in all patients, particularly those with non-life-threatening reactions. Further research into the validity of skin testing is required, along with the development of new diagnostic tests for antibiotic allergy.
Chromosome Conformation Paints Reveal the Role of Lamina Association in Genome Organization and Regulation
Authors: Luperchio Teresa R , Sauria Michael EG , Wong Xianrong , Gaillard Marie-Cécile , Tsang Peter , Pekrun Katja , Ach Robert A , Yamada N Alice , Taylor James , Reddy Karen L 
Published: March 2017

SummaryNon-random, dynamic three-dimensional organization of the nucleus is important for regulation of gene expression. Numerous studies using chromosome conformation capture strategies have uncovered ensemble organizational principles of individual chromosomes, including organization into active (A) and inactive (B) compartments. In addition, large inactive regions of the genome appear to be associated with the nuclear lamina, the so-called Lamina Associated Domains (LADs). However, the interrelationship between overall chromosome conformation and association of domains with the nuclear lamina remains unclear. In particular, the 3D organization of LADs within the context of the entire chromosome has not been investigated. In this study, we describe “chromosome conformation paints” to determine the relationshipin situbetween LAD and non-LAD regions of the genome in single cells. We find that LADs organize into constrained and compact regions at the nuclear lamina, and these findings are supported by an integrated analysis of both DamID and Hi-C data. Using a refined algorithm to identify active (A) and inactive (B) compartments from Hi-C data, we demonstrate that the LADs correspond to the B compartment. We demonstrate thatin situsingle cell chromosome organization is strikingly predicted by integrating both Hi-C and DamID data into a chromosome conformation model. In addition, using the chromosome conformation paints, we demonstrate that LAD (and B-compartment) organization is dependent upon both chromatin state and Lamin A/C. Finally, we demonstrate that small regions within LADs escape the repressive regime at the peripheral zone to interact with the A-compartment and are enriched for both transcription start sites (TSSs) and active enhancers.
A mathematical model for Dengue and Chikungunya in Mexico
Authors: Báez-Hernández Nohemí , Casas-Martínez Mauricio , Danis-Lozano Rogelio , Velasco-Hernández Jorge X. 
Published: March 2017

AbstractWe present a model that incorporates two co-circulating viral diseases, Dengue and Chikungunya, where we allow secondary infections from either of the two diseases. We only consider one vector population, Ae. aegypti since in the Mexican region where we set our scenarios, only this species has been reported to transmit both viruses. We estimate the basic reproduction number and perform numerical simulations for different scenarios where we may observe coexistence of Dengue and Chikungunya; we also compare the results of the model with Dengue and Chikungunya data from Mexico 2015 and we obtain a good model fit. To complete our findings we perform a sensitivity analysis, and calculate the partial rank correlation coefficients (PRCCs) to determine the parameter values influence on the reproduction numbers and predict fate of the diseases.We show that R0 for each one of the viruses is highly sensitive to the mosquito biting rate and the transmission rates for both diseases with positive influence and the average lifespan of mosquito along with the human recovery rate with negative influence on both diseases. Our results are consistent with those of previous authors.
Role of offender perception in treatment outcome
Authors: Sevene Andrea M. , Edlund John E. , Easton Caroline J. 
Published: March 2017

Purpose
The purpose of this paper is to address a possible interaction of cognitive distortions associated with substance dependency and intimate partner violence (IPV), and the effects on subsequent behavior. The primary focus was to investigate the relationship between offender perception (i.e. perception of family problems (FP) and perception of need for treatment for family problems (FPTx)) and treatment outcome (i.e. substance use and violence), among a unique sample of substance dependent male offenders of IPV. An additional investigation included the change in perception from baseline to the end of treatment.

Design/methodology/approach
In total, 63 participants were randomly assigned to one of two treatment conditions and assessed across 12 weeks of treatment.

Findings
Participants in the (FP+) (i.e. those who perceived family problems at baseline) and (FPTx+) (i.e. those who perceived a need for treatment for family problems at baseline) conditions reported a significantly greater change in the number of days of violence from baseline to the end of treatment, compared to participants in the (FP−) (i.e. those who did not perceive family problems at baseline) and (FPTx−) (i.e. participants who perceived no need for treatment at baseline) conditions. (FP+) and (FPTx+) participants had significant decreases in any violent behavior from pre- to post-treatment.

Originality/value
The results of this study highlight the importance of techniques aimed at improving clients’ ability to recognize and admit to problem behaviors, a critical component of cognitive-behavioral therapy, in an effort to increase their motivation for treatment, thus leading to greater treatment success.
Drug use and mental health in a Secure Children’s Home
Authors: Pates Richard Martin , Hooper Kristian 
Published: March 2017

Purpose
Secure Children’s Homes are safe environments where many of the most troubled children in British society are resident. These children are from either a criminal background or referred for protection of themselves and others from harm. There is often a history of drug use and diagnoses of mental health problems before admission. The purpose of this paper is to examine one Secure Children’s Home to determine the level of drug use prior to admission compared to surveys of children not in this environment and to examine the veracity of the mental health diagnoses.

Design/methodology/approach
This paper is a retrospective examination of case notes for admissions from 2014 to 2015.

Findings
The study found much higher levels of drug use than in the general population at similar age and a wide diagnosis of mental health problems prior to admission.

Research limitations/implications
Levels of harm from traumatic childhood events need to be recognised by referrers as maybe leading to attachment disorders and not mental health problems. More research is needed into the outcomes form Secure Children’s Homes in the long term.

Practical implications
The children in these homes do have as anticipated much higher levels of drug use than in the general population and high levels of mental health diagnoses which are not always borne out during their admission to the children’s home.

Originality/value
This is an examination of a special population of young people indicating high levels of drug use and mental health problems.
Why the availability of telecommuting matters
Authors: Masuda Aline D. , Holtschlag Claudia , Nicklin Jessica M. 
Published: March 2017

PurposeIn line with conservation of resources theory and signaling theory, the purpose of this paper is to conceptualize and test a multiple mediation model in which telecommuting affects engagement via perceived supervisor goal support and goal progress.Design/methodology/approachA three-phase longitudinal study carried out over ten months was used to test the hypotheses.FindingsIndividuals who worked in organizations that offer telecommuting were more engaged than those who worked in organizations that did not offer telecommuting. Furthermore, telecommuting availability was not only directly but also indirectly related to engagement via perceived supervisor goal support and goal progress. Engagement in general decreased over time. However, individuals who attained their personal work goals were able to maintain high levels of engagement.Research limitations/implicationsGiving employees the option to telecommute could increase employee engagement. This study is correlational in nature and relied on self-report data.Originality/valueThis is the first study examining the effects of telecommuting on engagement over a period of ten months. It is also the first study to use perceived supervisor goal support and goal progress as explanatory variables to the teleworking and engagement relationship.
Community benefits agreements (CBAs): a typology for shrinking cities
Authors: Patterson Kelly L. , Ranahan Molly , Silverman Robert M. , Yin Li 
Published: March 2017

Purpose
Community benefits agreements (CBAs) redistribute the benefits of new development to distressed communities and historically disenfranchised groups. They allow coalitions of labor and grassroots organizations to negotiate for concessions in the development process. Yet, CBAs are a relatively new tool used in planning and local economic development, and specification about their content and scope is evolving. Some of the earliest CBAs were negotiated in cities experiencing an influx of new growth and investment. However, less is known about the scope of CBA negotiations in shrinking cities where economic development is relatively anemic. The paper aims to discuss these issues.

Design/methodology/approach
This paper offers an extension to the existing literature through an exploratory analysis of the scope of CBAs in the ten fastest shrinking cities in the USA between 2000 and 2010. The analysis is organized in three parts. First, the authors present a CBA typology that differentiates among CBAs negotiated with developers in the public, private and nonprofit sectors. Second, the authors compare neighborhood conditions in shrinking cities with CBAs to those without negotiated agreements. Finally, the authors discuss critical cases where CBA negotiations have occurred in shrinking cities.

Findings
Grassroots coalitions have more leverage when negotiating for concessions with private sector developers vs developers from the public and nonprofit sectors. The added leverage is attributed to the high profile and limited public benefits associated with projects pursued by private sector developers. Moreover, shrinking cities face additional obstacles when negotiating CBAs. The authors concluded that cities with the highest levels of physical distress are the least likely to negotiate and adopt CBAs.

Originality/value
This paper contributes to the literature by focusing on CBAs in shrinking cities. It also highlights nuisances in CBA negotiations with developers from the private, public and nonprofit sectors. Although the analysis focused on the US context, the inclusion of these perspectives in the CBA typology provides researchers in other institutional settings with a common framework for comparative analysis.
Impact of other customers in high and low involvement services
Authors: Sengupta Aditi Sarkar , S Sreejesh 
Published: March 2017

Purpose
The purpose of this paper is to examine the effects of other customer perception (OCP) (Brocato et al., 2012) on focal customer’s service quality perception and revisit intention in high- and low-involvement services and the effect of customer’s need for uniqueness (NFU) as a boundary condition of the above relationships.

Design/methodology/approach
Following a theoretical methodology, hypotheses were developed to analyze the effect of OCP, service involvement and customer’s NFU. A 2 × 2 × 2 scenario-based experiment was designed. Multivariate analysis of variance (MANOVA) was used to test the hypotheses.

Findings
The analysis reveals that the presence of conforming (versus non-conforming) other customers improves service quality perception and revisit intention of focal customers in high-involvement services, but not in low-involvement services. However, the relationship between similarity perception and outcome variables does not hold good for high-NFU customers.

Practical implications
This study suggests that conforming and non-conforming other customers are critical in forming service quality perception of high-involvement services, and highlights the boundary condition of this relationship. If service managers take service involvement and individual differences into account, and strategize their service offering aligned to their target customers, influence of other customers can be managed more efficiently.

Originality/value
As this study is one of the first empirical studies to focus on the effect of OCP on service quality perception and examine its boundary condition, it contributes significantly to the body of knowledge. Future research directions are discussed and managerial implications are proposed.
Understanding supervision in health and social care through the experiences of practitioners in Scotland
Authors: Allbutt Helen , Colthart Iain , El-Farargy Nancy , Sturgeon Caroline , Vallis Jo , Lough Murray 
Published: March 2017

Purpose
The purpose of this paper is to describe a collaborative study on supervision with health and social care practitioners in Scotland. The study attempted to gain a better understanding about the use and benefit of supervision from a multiprofessional perspective.

Design/methodology/approach
Consultation events with health and social care staff and 12 informant interviews were undertaken. Data analysis was via the Framework Method.

Findings
Managers were more likely to conceive of supervision as a positive intervention than those in lower pay bands. The practice of supervision was variable. Not all staff appeared to take part in regular supervisory activities even when it was mandated. A lack of professional, organisational or local commitment to implement robust supervisory structures and processes was seen as the major barrier to effective supervision.

Research limitations/implications
This was a small study, thus findings would need to be confirmed by health and social care staff working across a wider spectrum of disciplines and regions across Scotland.

Practical implications
A combination of factors would seem to determine effective supervisory practice. Supervision was perceived to be of benefit when individuals were willing to participate fully, when there was reflection and planned action, constructive challenge, respectful relationships, regular and protected sessions and processes were appropriate to an employee’s circumstances.

Originality/value
This study situates supervision in the current context of health and social care and finds it to be an irregular practice. The findings confirm the existing literature about the importance of supervisor-supervisee relationships but explain differing perceptions of supervision in terms of staff seniority.
Bringing integration home
Authors: Kaehne Axel , Birrell Derek , Miller Robin , Petch Alison 
Published: March 2017

Purpose
The purpose of this paper is to outline relevant policies on the integration of health and social care (HSC) in the four home nations: Scotland, Wales, Northern Ireland and England and offer a comparison of emphasis and approaches and draw out general insights on the implementation of integrated care policy.

Design/methodology/approach
The paper is written as a piece of critical reflection by drawing on the authors’ knowledge and expertise and wider evidence where available.

Findings
Since 2010, HSC integration has started to diverge significantly in the four constituent countries of the UK. Although England and Wales have undergone considerable re-organisation of the NHS, Scotland and Northern Ireland have largely been marked by organisational continuity. However, beyond organisational differences, policy approaches, policy emphases and implementation strategies have also started to show considerable dissimilarity across the UK. An important contributory factor may be different ideological perspectives on the role of competition and pilots, partnership, patient choice and organisational incentives to bring about change in the field.

Research limitations/implications
The paper identifies a serious lack of comparative research in integration policy, despite the considerable opportunities for quasi-experimental studies. This lack of empirical research impedes shared learning across the home nations.

Originality/value
The paper presents a descriptive comparison of current integration policy between HSC providers in the four home nations. It reveals considerable opportunities for further research and comparative modelling of integration approaches.
Succession planning and family business performance in SMEs
Authors: Mokhber Mozhdeh , Gi Gi Tan , Abdul Rasid Siti Zaleha , Vakilbashi Amin , Mohd Zamil Noraiza , Woon Seng Yee 
Published: March 2017

PurposeThe purpose of this paper is to examine the impact of preparation level of heirs and the relationship between family and business members on the performance of family business in small- and medium-sized enterprises (SMEs) in Malaysia.Design/methodology/approachA quantitative research design involving the use of a survey questionnaire was implemented to investigate the influences of succession planning factors on the performance of family business in SMEs. The survey was conducted on 50 family business successors in Malaysian SMEs.FindingsThe result showed that the two studied factors – preparation level of heirs and the relationship between family and business members – have a positive impact on the performance of family business.Research limitations/implicationsThe research concentrated on the performance of family business in SMEs in Malaysia’s southern region. The generalization therefore must be made very cautiously to the overall Malaysian SMEs.Practical implicationsThe findings help family businesses to better understand the importance of the preparation level of heirs and the relationship between family and business members on business performance. This study shows the importance of key factors influencing succession planning so that the successor to the family business can bring the family firm to the next stage of success.Originality/valueThis study serves as a reference or guide for the management of family businesses to better understand the important factors for effective succession planning. It considers the best possible preparation and family-related factors affecting the end results of business, particularly in Malaysian SMEs.