bluuebunny/crossref_metadata_2025_split huggingface dataset:
Universal privacy‐preserving platform for SecaaS services
Authors: Kurek Tytus , Niemiec Marcin , Lason Artur , Pach Andrzej R. 
Published: August 2017

SummaryWith the rapid growth of the Security‐as‐a‐Service market, concerns about privacy in exposing customer security policies to Cloud Service Providers have become critical. To resolve these issues, several solutions have been proposed over the past few years, each for a different kind of security service. However, as the number of security services outsourced into a cloud continues to grow, the need for a unified solution has become significant. This article introduces and presents a universal privacy‐preserving platform for SecaaS services that is based on a hybrid cloud architecture for maintaining the confidentiality of the customer's security policy. It is shown that this platform can be applied to all security services whose security policies can be represented in the form of a decision tree. This includes the vast majority of existing cloud‐based security services. With the small number of computationally‐expensive operations performed in a private cloud, the solution also does not require the implementation of a performant security engine on the customer's premises, allowing full advantage to be taken of private cloud offloading. It is also shown that the platform achieves better performance results than other existing solutions of this type. These findings were confirmed by experimental results.
Synthesis of 4H‐Benzo[e][1,3]oxazin‐4‐ones by a Carbonylation–Cyclization Domino Reaction of ortho‐Halophenols and Cyanamide
Authors: Åkerbladh Linda , Chow Shiao Y. , Odell Luke R. , Larhed Mats 
Published: August 2017

AbstractA mild and convenient one‐step preparation of 4H‐1,3‐benzoxazin‐4‐ones by a domino carbonylation–cyclization process is developed. Readily available ortho‐iodophenols are subjected to palladium‐catalyzed carbonylative coupling with Mo(CO)6 and cyanamide, followed by a spontaneous, intramolecular cyclization to afford 4H‐1,3‐benzoxazin‐4‐ones in moderate to excellent yields. Furthermore, the scope of the reaction is extended to include challenging ortho‐bromophenols. Finally, to highlight the versatility of the developed method, Mo(CO)6 is successfully replaced with a wide array of CO‐releasing reagents, such as oxalyl chloride, phenyl formate, 9‐methylfluorene‐9‐carbonyl chloride, and formic acid, making this an appealing strategy for the synthesis of 4H‐benzo[e][1,3]oxazin‐4‐ones.
Recent advances in genomic profiling of adenosquamous carcinoma of the pancreas
Authors: Marcus Rebecca , Maitra Anirban , Roszik Jason 
Published: August 2017

AbstractAdenosquamous carcinoma of the pancreas (ASCP) is a mixed tumor type which contains squamous cell carcinoma and also ductal adenocarcinoma components. Due to the rarity of this malignancy, only very limited genomic profiling has been performed. A recent paper by Fang et al. published in The Journal of Pathology contributed to our knowledge of genomic alterations by performing whole‐genome and ‐exome sequencing of 17 ASCP tumors. They found major genomic similarities to pancreatic ductal adenocarcinoma; however, the p53 pathway was altered in a greater proportion of cases, while a high frequency of 3p loss was a distinct copy number alteration pattern observed in ASCP. Laser capture microdissection revealed that adenocarcinoma and squamous carcinoma components of ASCP harbor similar genomic variations, indicating that the origin of tumor components is the same or similar. Although the study published by Fang et al. increases our knowledge of this rare mixed tumor type, further investigation, including RNA sequencing, will be needed to fully characterize this malignancy and to aid the development of novel treatment approaches. Copyright © 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Bridge the gap: The need for harmonized regulatory and ethical standards for postmarketing observational studies
Authors: Urushihara Hisashi , Parmenter Louise , Tashiro Shimon , Matsui Kenji , Dreyer Nancy 
Published: August 2017

AbstractDrug safety issues do not respect national borders. Hence, addressing a safety question may necessitate globally coordinated efforts between regulatory authorities and market authorization holders (MAHs) to draw reliable conclusions. Regulatory authorities have shared responsibility with MAHs sponsoring postmarketing nonintervention studies in determining study goals and design. Their shared accountabilities include what will be investigated and how the data will be retrieved to ensure appropriate study quality required for regulatory decision making. The need for a harmonized framework and ethical standards for postmarketing observational studies is well recognized but has been lacking even among the United States, European Union, and Japan, which are so‐called International Conference on Harmonisation (ICH) regions. A recent update of the Council for International Organizations of Medical Sciences International Ethical Guidelines for Health‐Related Research Involving Humans provides further clarification on provisions for informed consent and the role of research ethics committees. However, without incorporation into legislative structures, the future impact of these guidelines is uncertain. This lack of harmonization leads to a complex and uncertain framework for ethical review and for participant informed consent, resulting in numerous inefficiencies in the regulatory postmarketing observational studies. The regulatory frameworks for postmarketing observational studies conducted under the auspices of regulatory agencies in the 3 regions are reviewed, with a focus on ethical requirements and opportunities for efficiencies.
Effect of KF absorber treatment on the functionality of different transparent conductive oxide layers in CIGSe solar cells
Authors: Keller Jan , Chalvet Francis , Joel Jonathan , Aijaz Asim , Kubart Tomas , Riekehr Lars , Edoff Marika , Stolt Lars , Törndahl Tobias 
Published: August 2017

AbstractThis contribution studies the impact of the KF‐induced Cu(In,Ga)Se2 (CIGSe) absorber modification on the suitability of different transparent conductive oxide (TCO) layers in solar cells. The TCO material was varied between ZnO:Al (AZO), ZnO:B (BZO), and In2O3:H (IOH). It is shown that the thermal stress needed for optimized TCO properties can establish a transport barrier for charge carriers, which results in severe losses in fill factor (FF) for temperatures >150°C. The FF losses are accompanied by a reduction in open circuit voltage (Voc) that might originate from a decreased apparent doping density (Nd,app) after annealing. Thermally activated redistributions of K and Na in the vicinity of the CdS/(Cu,K)‐In‐Se interface are suggested to be the reason for the observed degradation in solar cell performance. The highest efficiency was measured for a solar cell where the absorber surface modification was removed and a BZO TCO layer was deposited at a temperature of 165°C. The presented results highlight the importance of well‐designed TCO and buffer layer processes for CIGSe solar cells when a KF post deposition treatment (KF‐PDT) was applied.
Maternal body mass index: Relation with infant respiratory symptoms and infections
Authors: Rajappan Ashley , Pearce Anna , Inskip Hazel M. , Baird Janis , Crozier Sarah R. , Cooper Cyrus , Godfrey Keith M. , Roberts Graham , Lucas Jane S.A. , Pike Katharine C. ,   The Southampton Women's Survey Study Group
Published: August 2017

AbstractBackgroundMaternal obesity is increasingly prevalent in many westernized countries. Many studies report associations between maternal obesity and childhood wheeze or asthma but few have considered maternal obesity in relation to respiratory infections or symptoms other than wheeze during infancy. This study assesses the relationship between maternal BMI and reported wheeze, cough and respiratory infections during the first year of life.MethodsIn 2799 mother‐child pairs, we examined the relations between maternal pre‐pregnancy BMI and pregnancy weight gain and reported offspring wheeze, prolonged cough, lower respiratory tract infection, croup, and ear infection before age 1 year, along with reported diarrhea or vomiting. Maternally reported paternal BMI was included in the models as a proxy for unmeasured confounding by shared familial factors.ResultsHigher maternal BMI was associated with increased risks of offspring wheeze, prolonged cough and lower respiratory tract infection (relative risks (95%CI) per 5 kg/m2 1.09 (1.05‐1.13), 1.09 (1.03‐1.14), and 1.13 (1.07‐1.20), respectively). These associations remained after adjusting for maternally reported paternal BMI. No associations were found with croup, ear infection, or diarrhea or vomiting. Pregnancy weight gain was not associated with any of the offspring symptoms or illnesses.DiscussionHigher maternal BMI is associated with increased risk of wheeze, cough, and maternally reported lower respiratory tract infection in infancy. These associations were independent of maternally reported paternal BMI. These observations might be explained by intrauterine effects of maternal obesity upon respiratory or immune development.
iTRAQ‐Based Quantitative Proteomic Analyses of High Grade Esophageal Squamous Intraepithelial Neoplasia
Authors: Zhang Jingjing , Zhi Chunchun , Zhen Fuxi , Yuan Xiaoqin , Jiao Chunhua , Zhu Hong , Zhu Hui , Feng Yadong 
Published: August 2017

AbstractEsophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and is the fourth most lethal cancer in China. Little is known about the proteome of high grade esophageal squamous intraepithelial neoplasia (HGN), which is a premalignant lesion of ESCC. A quantitative proteomic analysis using an isobaric tag for relative and absolute quantification (iTRAQ) approach is used to characterize the protein expression profiles in HGN. Among the 3156 identified proteins, a total of 236 proteins are discovered to be differentially expressed. Compared with paired normal esophageal epithelial tissues, 138 proteins are upregulated and 98 proteins are downregulated in HGN. Bioinformatics analyses are performed according to gene ontology, clusters of orthologous groups, and kyoto encyclopedia of genes and genomes enrichment analyses. Six differentially expressed proteins are chosen and validated by Western blotting. The results of the study increase our understanding of early tumorigenesis during ESCC, and provide insights into the proteome at the initial stages of the disease that can be used to identify potential biomarkers for early diagnosis and for therapeutic targets.
Conceptual considerations on exposure assessment goals for aquatic pesticide risks at EU level
Authors: Boesten Jos JTI 
Published: August 2017

AbstractAssessment of the risk to aquatic organisms is an important aspect of pesticide registration. This assessment must be based on well‐defined exposure assessment goals (EAGs). However, these goals have not yet been defined for the EU authorization procedure. The definition of an aquatic EAG has seven elements, including: type of water body, spatial dimension of this body, spatial population of water bodies, multi‐year temporal population of concentrations for a single water body, and the space‐time percentile combination to be selected from the spatio‐temporal population of concentrations. The seven elements are split into 16 items, three which are within the risk‐management domain. The remaining 13 scientific items should preferably be based on consistency with landscape‐level approaches. Subdivision of the spatial population of water bodies on the occurrence of exposure routes should be avoided (although this is current practice). The multi‐year temporal population of concentrations should be based on all years in rotational crops (including years without applications). Risk managers should be offered a suite of coherent packages of EAGs and effect assessment goals from which they can select the package corresponding to the desired overall level of protection. © 2017 Society of Chemical Industry
Baseline susceptibility of spotted wing Drosophila (Drosophila suzukii) to four key insecticide classes
Authors: Van Timmeren Steven , Mota‐Sanchez David , Wise John C , Isaacs Rufus 
Published: August 2017

AbstractBACKGROUNDThe invasive drosophilid pest, Drosophila suzukii Matsumura, is affecting berry production in most fruit‐producing regions of the world. Chemical control is the dominant management approach, creating concern for insecticide resistance in this pest. We compared the insecticide susceptibility of D. suzukii populations collected from conventional, organic or insecticide‐free blueberry sites.RESULTSThe sensitivity of D. suzukii to malathion and spinetoram declined slightly across the 3 years of monitoring, whereas it was more consistent for methomyl and zeta‐cypermethrin. The sensitivity of D. suzukii to all four insecticides (LC50 and LC90 values) did not differ significantly among the blueberry fields using different management practices.CONCLUSIONSThe baseline sensitivity of D. suzukii has been characterized, allowing future comparisons if field failures of chemical control are reported. The concentration achieving high control indicates that effective levels of control can still be achieved with field rates of these four insecticides. However, declining susceptibility of some populations of D. suzukii to some key insecticides highlights the need for resistance monitoring. © 2017 Society of Chemical Industry
In vitro Study of Five Herbs Used Against Microbial Infections in Burundi
Authors: Ngezahayo Jérémie , Ribeiro Sofia Oliveira , Fontaine Véronique , Hari Léonard , Stévigny Caroline , Duez Pierre 
Published: August 2017

The emergence of antimicrobial resistant infectious diseases remains a major threat to worldwide public health, in developed and in developing countries. Therefore, new antimicrobial agents acting by new mechanisms of action are urgently needed. As plants used in traditional medicine may help to overcome these problems, Justicia subsessilis, Platostoma rotundifolium, Pavetta ternifolia, Stomatanthes africanus, and Virectaria major (plants highly cited to be used against microbial infections in traditional Burundian medicine) were studied to assess their traditional use efficacy. We conducted a preliminary phytochemical screening of the extracts, as well as their direct and indirect (effect on antibiotic resistance) antibacterial activity on four bacterial strains (Staphylococcus sp. and Escherichia coli) by broth microdilution methods. All five medicinal plants investigated in this work were found to have direct antibacterial activity against all tested bacterial strains (minimum inhibitory concentration = 62.5–1000 μg/mL) that may support the use of these species in traditional Burundian medicine. Extracts (with no direct antibacterial activity), tested at 200 μg/mL, decreased the MIC values of β‐lactams and aminoglycoside antibiotics by a factor of 2 to 64‐fold. These interactions between plant extracts and antibiotics could open an avenue of research against antibiotic resistance. Copyright © 2017 John Wiley & Sons, Ltd.
In vitro Antitubercular Activity of 3‐Deoxysappanchalcone Isolated From the Heartwood of Caesalpinia sappan Linn.
Authors: Seo Hoonhee , Kim Sukyung , Mahmud Hafij Al , Islam Md Imtiazul , Nam Kung‐Woo , Lee Byung‐Eui , Lee Hanna , Cho Myoung‐Lae , Shin Heung‐Mook , Song Ho‐Yeon 
Published: August 2017

Responsible for nearly 1.5 million deaths every year, the infectious disease tuberculosis remains one of the most serious challenges to global health. The emergence of multidrug‐resistant tuberculosis and, more recently, extensively drug‐resistant tuberculosis poses a significant threat in our effort to control this epidemic. New drugs are urgently needed to combat the growing threat of antimicrobial resistance. To achieve this goal, we screened approximately 500 species of medicinal plant methanol extracts and their solvent partitioned fractions for potential inhibitors of Mycobacterium tuberculosis growth. Using microdilution screening, the ethyl acetate solvent partitioned fraction from the heartwood of Caesalpinia sappan exhibited strong antitubercular activity. We isolated the active compound and identified it as 3‐deoxysappanchalcone. The extracted 3‐deoxysappanchalcone possessed activity against both drug‐susceptible and drug‐resistant strains of M. tuberculosis at MIC50s of 3.125–12.5 μg/mL in culture broth and MIC50s of 6.25–12.5 μg/mL inside macrophages and pneumocytes. 3‐Deoxysappanchalcone was also found to act in partial synergy with streptomycin/ethambutol against M. tuberculosis H37Rv. 3‐Deoxysappanchalcone had no cytotoxicity against the A549 cell line up to a concentration of 100 μg/mL (selectivity index > 8–32). Further studies are warranted to establish the in vivo effect and therapeutic potential of 3‐deoxysappanchalcone. Copyright © 2017 John Wiley & Sons, Ltd.
Does low‐energy collision‐induced dissociation of lithiated and sodiated carbohydrates always occur at anomeric carbon of the reducing end?
Authors: Tsai Shang‐Ting , Chen Jien‐Lian , Ni Chi‐Kung 
Published: August 2017

RationaleCollision‐induced dissociation (CID) tandem mass spectrometry is one of the major methods in the structural determination of carbohydrates. Previous experimental studies and theoretical investigation of lithiated and sodiated underivatized carbohydrates seem to indicate that dehydration reactions and cross‐ring dissociation of low‐energy CID mainly occur at the anomeric carbon of the reducing end. However, these studies only investigated a few carbohydrates.MethodsESI‐MS/MS spectra of [M + Li]+ and [M + Na]+ ions of several 18O1‐labeled monosaccharides and disaccharides at O1 of the reducing end were studied using a linear ion trap mass spectrometer.ResultsDissociations from the losses of both labeled and unlabeled neutral fragments were observed. The branching ratios of dissociations from the losses of unlabeled neutrals for dehydration reactions are larger than that for cross‐ring dissociation; lithiated carbohydrates are larger than sodiated carbohydrates, and 1‐4 linkages of disaccharides are larger than the other linkages. For some lithiated carbohydrates, dehydration reactions from the losses of unlabeled neutrals have larger branching ratios than that from the losses of labeled neutrals. The fragments from the losses of unlabeled neutrals investigated using MS3 showed that the losses of unlabeled H2O mainly occur at the reducing monomer for sodiated carbohydrates, but the losses of unlabeled C2H4O2 for lithiated carbohydrates can occur at both reducing and nonreducing monomers. The ratio of B1 and Y1 ions to C1 and Z1 ions of disaccharides is related to the cis or trans configuration of the O1 and O2 atoms in the nonreducing monomer. The results are explained by the properties of transition states of dissociation channels.ConclusionsOur data shows that dehydration reactions and cross ring dissociation do not always occur at the anomeric carbon atom of the reducing monomer.
A hydroecological model to assess the relative effects of groundwater abstraction and fine sediment pressures on riverine macro‐invertebrates
Authors: Bradley D.C. , Streetly M.J. , Cadman D. , Dunscombe M. , Farren E. , Banham A. 
Published: August 2017

AbstractTo ensure that the environment is adequately protected and abstractors are fairly regulated, hydroecological assessment tools are needed that give local interpretation, indicate where ecological communities might not be resilient to current or future abstraction pressures, and take account of the effect of other stressors. These tools should ideally be transferrable across different river catchments. This study presents a hydroecological model indicating that macro‐invertebrates were not resilient to long‐term, steady‐state levels of groundwater abstraction when flows at Q75 were reduced by more than 50% in unpolluted streams in the West Midlands of England. The proportion of silt and clay covering the substratum and distance from source were also significant predictors of ecological condition, but did not interact with the abstraction effect. Combinations of different biotic indices and supplementary field observations of catchment land use gave additional evidence of the impacts of excessive inputs of fine sediment overriding the effects of abstraction at some locations. This study has shown that regional hydroecological models can be used with existing environmental flow indicators and other local environmental information as a weight of evidence to identify where abstraction and excessive inputs of fine sediment need to be mitigated separately or together to achieve the full ecological benefits. Such regional hydroecological models can increase the certainty of regulatory decisions made at the local scale for licencing abstraction at current use and predicted future levels.
Photophysical, Electrochemical Studies of Novel Pyrazol‐4‐yl‐2,3‐dihydroquinazolin‐4(1H)‐ones and Their Anticancer Activity
Authors: Kamble Atulkumar A. , Kamble Ravindra R. , Chougala Lakkanna S. , Kadadevarmath Jagadish S. , Maidur Shivaraj R. , Patil Parutagouda S. , Kumbar Mahadev N. , Marganakop Sheetal B. 
Published: August 2017

AbstractA series of novel 2,3‐dihydroquinazolin‐4(1H)‐ones 7 a‐g were designed, synthesized and were characterized by IR, 1H & 13C NMR, MS, and elemental analysis. The optical and electrochemical properties have been studied using UV‐Vis absorption, fluorescence spectroscopy, life time and cyclic voltammetry (CV) measurements. Quantum yield and effect of solvents for the compounds 7 a‐g were investigated. Density Functional Theory (DFT) computations have been carried out for all the synthesized compounds and the computed values found to be approximately in close agreement with the experimental results. Further, the compounds 7 a, 7 d, 7 f and 7 g were evaluated for their anticancer activity at National Cancer Institute, NIH, Bethesda, USA and have shown moderate to good anticancer activities.
Copper‐Catalyzed Oxidative Cross‐Coupling of P(O)‐OH Compounds with Aryl Boronic Acids
Authors: Xiong Biquan , Cheng Qing , Hu Chenghong , Zhang Pangliang , Liu Yu , Tang Kewen 
Published: August 2017

AbstractA novel copper‐catalyzed oxidative cross‐coupling reaction of P(O)‐OH compounds with aryl boronic acids is illustrated. It is a simple way to generate a broad spectrum of functionalized O‐aryl phosphinates, phosphonates, and phosphates from basic starting materials with moderate to excellent yields. Furthermore, a plausible mechanism has been proposed for the reaction.