bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of right and left ventricular systolic dysfunction on perioperative outcome and long‐term survival after transcatheter aortic valve replacement
Authors: Griese Daniel P. , Kerber Sebastian , Barth Sebastian , Diegeler Anno , Babin‐Ebell Jörg , Reents Wilko 
Published: April 2017

BackgroundAim of the study was to determine the impact of right‐ and left‐ventricular systolic dysfunction on perioperative outcome and long‐term survival after TAVR.MethodsStudy population consisted of 702 TAVRs between 2009 and 2014, 345 by TF, 357 by TA route. RV and LV function were determined by TAPSE and LVEF measurement during baseline echocardiography. Patients were divided according to TAPSE (>18 mm/14‐18 mm/<14 mm) and LVEF (>50%/30‐50%/<30%) tertiles. Outcome at day‐30 and Kaplan‐Meier 4‐year survival were analyzed.ResultsImpaired RV and LV‐function did not adversely affect mortality, stroke, bleeding, and vascular‐complications at 30 days. Patients with TAPSE < 14 mm displayed elevated rate of renal failure requiring dialysis (11%; P < 0.01). Kaplan‐Meier survival was adversely affected by RV‐systolic dysfunction RVSD (P < 0.01). Multivariate analysis revealed that impaired RVSD but not LVSD was an independent determinant for late mortality (hazard ratio TAPSE 14‐18 mm: 1.53; P = 0.02; TAPSE <14 mm: 2.12; P < 0.01).ConclusionsPeri‐operative mortality and risk of stroke after TAVR are not adversely affected by preexisting RV or LV dysfunction. Long‐term survival is impaired in patients with RVSD. RVSD but not LVSD is an independent risk factor for late mortality. TAVR should be the preferred therapy for patients with RVSD and LVSD, especially when patient is suitable for TF.
Real‐life data regarding acute procedural success and 1‐year clinical outcome of desolve bioresorbable scaffolds
Authors: Gunes Haci Murat , Gokdeniz Tayyar , Kizilirmak Yilmaz Filiz , Demir Gultekin Gunhan , Guler Ekrem , Babur Guler Gamze , Karaca Oğuz , Cakal Beytullah , Omaygenç Mehmet Onur , İbişoğlu Ersin , Boztosun Bilal 
Published: April 2017

ObjectivesWe aimed to evaluate the peri‐procedural success of DESolve bio‐resorbable scaffolds (BRSs) and analyzed real‐life data about major cardiac events during 1‐year follow‐up.BackgroundThere is little information about real‐life data of DESolve BRS which is a novel stent technology offering various advantages over drug eluting stents and commonly used in daily cardiology practice.MethodsWe conducted this single‐center and non‐randomized cross‐sectional study from June 2015 through August 2016 in Medipol University Department of Cardiology and included 117 patients undergoing single or multivessel percutaneous coronary interventions (PCI) with novolimus‐eluting BRS devices (152 scaffolds) (Elixir Medical Corporation). Study end points were acute device and procedural success, scaffold thrombosis and major adverse cardiac event (MACE) rates of DESolve BRS.ResultsDevice success was 96.7% and procedural success was 99.3%. We detected MACE rate as 0.9% while clinical‐driven target lesion revascularization was performed in one patient. None of the patients experienced scaffold thrombosis or death. Peri‐procedural complications were reported in three patients.ConclusionsHigh rates of successful scaffold implantations, low rates of peri‐procedural complications, and major cardiac events in long‐term suggest that DESolve scaffolds can safely and effectively be used in daily intervention practice by particularly experienced operators.
The Meteoritical Bulletin, No. 103
Authors: Ruzicka Alex , Grossman Jeffrey , Bouvier Audrey , Agee Carl B. 
Published: April 2017

AbstractMeteoritical Bulletin 103 contains 2582 meteorites including 10 falls (Ardón, Demsa, Jinju, Križevci, Kuresoi, Novato, Tinajdad, Tirhert, Vicência, Wolcott), with 2174 ordinary chondrites, 130 HED achondrites, 113 carbonaceous chondrites, 41 ureilites, 27 lunar meteorites, 24 enstatite chondrites, 21 iron meteorites, 15 primitive achondrites, 11 mesosiderites, 10 Martian meteorites, 6 Rumuruti chondrites, 5 ungrouped achondrites, 2 enstatite achondrites, 1 relict meteorite, 1 pallasite, and 1 angrite, and with 1511 from Antarctica, 588 from Africa, 361 from Asia, 86 from South America, 28 from North America, and 6 from Europe. Note: 1 meteorite from Russia was counted as European. The complete contents of this bulletin (244 pages) are available on line. Information about approved meteorites can be obtained from the Meteoritical Bulletin Database (MBD) available on line at http://www.lpi.usra.edu/meteor/.
Premastication and length for age among children under 24 months in Laos
Authors: Conkle Joel , Kounnavong Sengchanh , Young Melissa , Stein Aryeh D. 
Published: April 2017

AbstractPremastication of infant food by caregivers is common in Laos. Premastication is hypothesized to have both positive and negative implications for children, but the net effect of premastication on child health and nutrition is largely unknown because of a lack of research. This study quantitatively describes premastication in 5 provinces of Laos and examines the associations between premastication and the length of young children. We analyzed cross‐sectional data from the Laos 2015 Food and Nutrition Security Survey to characterize premastication among children under 2 years of age (n = 1,661) and to test associations between premastication and child length‐for‐age z‐score. We explored associations using multilevel mixed effects linear regression. Among children 0–23 months, 27.2% of mothers reported giving premasticated food in the past week. Receipt of premasticated food was inversely associated with length‐for‐age z‐score after controlling for potential confounders (child's age, ethno‐linguistic group, wealth, and parity) among children 6–13 months (β −0.36, CI [−0.68, −0.04]) and among children 14–23 months (β −0.43, CI [−0.81, −0.05]). For breastfed children 0–5 months who received complementary food, the coefficient was similar, but the association was not statistically significant (β −0.42, CI [−1.2, 0.37]). Premastication is a common feeding practice for children 0–23 months of age, and many infants consume premasticated food on a daily basis. There was a negative relationship between premastication and child length. However, given the cross‐sectional nature of this study and potential unmeasured confounding factors, reverse causality or confounding cannot be ruled out. Longitudinal studies are needed to develop recommendations on premastication.
Calcium and electrical signaling in arterial endothelial tubes: New insights into cellular physiology and cardiovascular function
Authors: Behringer Erik J. 
Published: April 2017

AbstractThe integral role of the endothelium during the coordination of blood flow throughout vascular resistance networks has been recognized for several decades now. Early examination of the distinct anatomy and physiology of the endothelium as a signaling conduit along the vascular wall has prompted development and application of an intact endothelial “tube” study model isolated from rodent skeletal muscle resistance arteries. Vasodilatory signals such as increased endothelial cell (EC) Ca2+ ([Ca2+]i) and hyperpolarization take place in single ECs while shared between electrically coupled ECs through gap junctions up to distances of millimeters (≥2 mm). The small‐ and intermediate‐conductance Ca2+ activated K+ (SKCa/IKCa or KCa2.3/KCa3.1) channels function at the interface of Ca2+ signaling and hyperpolarization; a bidirectional relationship whereby increases in [Ca2+]i activate SKCa/IKCa channels to produce hyperpolarization and vice versa. Further, the spatial domain of hyperpolarization among electrically coupled ECs can be finely tuned via incremental modulation of SKCa/IKCa channels to balance the strength of local and conducted electrical signals underlying vasomotor activity. Multifunctional properties of the voltage‐insensitive SKCa/IKCa channels of resistance artery endothelium may be employed for therapy during the aging process and development of vascular disease.
Treatment effects of Reverse Twin‐Block and Reverse Pull Face Mask on craniofacial morphology in early and late mixed dentition children
Authors: Fareen N. , Alam M. K. , Khamis M. F. , Mokhtar N. 
Published: April 2017

Structured AbstractObjectiveReverse Twin‐Block (RTB) and Reverse Pull Face Mask (RPFM) appliances are used to correct Class III malocclusion in growing patients. Aim of this retrospective study was to compare and analyse craniofacial changes produced by RTB and RPFM in the early and late mixed dentition in Malay children with Class III malocclusion.MethodsData consisted of pre‐ and post‐treatment lateral cephalograms of 95 children, 49 patients with RTB and 46 patients with RPFM, divided into an early (8‐9 year) and late (10‐11 year) group. Treatment changes were assessed by the Ricketts analysis using CASSOS software, where 71 anatomic landmarks were identified in each cephalogram. Paired and independent t tests were performed for statistical comparison.ResultsPaired t test revealed significant changes in facial axis, facial angle, MD plane to FH, lower facial height, mandibular arc, maxillary convexity, U1 to APog, L1 to APog, L1 to APog angle and upper lip to E‐plane measurements in RPFM, whereas significant changes were found in facial taper, U1 to APog and lower lip to E‐plane values with RTB in the early treatment group. Independent t test revealed significant changes in U1 to APog, L1 to APog and U6 to PtV values in the RTB group. Post‐treatment comparison of RTB and RPFM showed significant differences in L1 to APog and L1 to APog angle values.ConclusionsRPFM revealed more favourable craniofacial changes than RTB, particularly in the late mixed dentition stage.
Scattering contribution to the double‐pass PSF using Monte Carlo simulations
Authors: Christaras Dimitrios , Ginis Harilaos , Pennos Alexandros , Artal Pablo 
Published: April 2017

AbstractPurposeScattering in the eye occurs mainly at two sites: the eye's optical media and the deeper retinal layers. Although the two phenomena are often treated collectively, their spatial domain of contribution to the double‐pass Point Spread Function (PSF) is different: the fundus effect is limited to the narrow and middle part of the PSF whereas scattering in the eye's optics extends also to wide angles. The objective of this work was to determine the domain of contribution at the double‐pass PSF of light scattered in the ocular media and the ocular fundus, using simulated and experimental data for two different wavelengths and for two different pigmentations.MethodsDiffuse reflection was simulated using Monte Carlo simulations for a four‐layer retinal fundus model. Four situations were simulated in total for two different choroidal absorptions at two different wavelengths. Light diffusion in the fundus was the only phenomenon considered in the model. The simulations were compared against experimental fundus reflection data obtained in a previous study.ResultsThe simulations showed that at 560 nm, diffusion in the fundus causes light to extend to a radius of 2°, independently of the choroidal pigmentation, whereas at 650 nm it extends to radii of 4.5° and 4° for low and high choroidal pigmentation respectively. Experimental data showed a similar behaviour at low angles where light diffusion in the fundus is dominant, but different at higher angles due to scattering in the ocular media.ConclusionThe spatial contribution of light diffused in the ocular fundus to the PSF was found to be limited to narrower angles compared to that of scattering at the ocular media. The comparison of simulated and optical data showed that beyond 2° at 560 nm and 4–4.5° at 650 nm the only phenomenon contributing to the PSF is scattering in the ocular media, whereas the fundus contribution can be assumed as negligible.
LncRNA‐H19 Modulates Wnt/β‐catenin Signaling by Targeting Dkk4 in Hindlimb Unloaded Rat
Authors: Li Bing , Liu Jun , Zhao Jie , Ma Jian‐xiong , Jia Hao‐bo , Zhang Yang , Xing Guo‐sheng , Ma Xin‐long 
Published: April 2017

ObjectiveTo investigate the biological functions of long noncoding RNA‐H19 (H19) in the pathogenesis of disuse osteoporosis (DOP).MethodsFifty‐four male Sprague Dawley (SD) rats were randomly divided into three groups: baseline control (BC, 6), age‐matched control (AC, 24), and hindlimb unloading (HLU, 24). The rats in the BC group were sacrificed at the beginning of the experiment, while the AC and HLU rats were sacrificed at different times (7, 14, 21 and 28 days after HLU). The DOP model was verified by micro‐CT scan, and quantitative real‐time polymerase chain reaction (qRT‐PCR) was used to quantify the expression of osteogenic genes (OPG, RunX2 and OPG). Gene sequencing and bioinformatic analysis were performed to find H19 target genes and the associated signaling pathway, which were first verified on tissue samples. Further verification was performed by knocking down the H19 and related gene in rat osteoblast cell line (UMR106 cell). Then, the changes of associated signaling pathway and osteogenic function were examined to confirm the prediction of the bioinformatic analysis.ResultsMicro‐CT scans and quantitative real‐time polymerase chain reaction (qRT‐PCR) tests showed progressively deteriorated trabecular bone and decreased level of osteogenic genes in the metaphysis of distal femur during HLU, indicating the successful establishment of a DOP model. According to RNA sequencing, 1351 mRNA and 464 lncRNA were abnormally expressed in response to mechanical unloading, in which the H19 decreased 2.86 fold in HLU rats. There were 1426 mRNA predicted to be the target genes of H19, and KEGG pathway analysis suggested that Wnt signaling pathway (Wnt signaling) was the top pathway responsible for these target genes. In the Wnt‐associated genes targeted by H19, 11 were differentially expressed between HLU and AC rats, among which Dkk4 increased 2.44 fold in HLU rats when compared to normal controls. These results of sequencing and bioinformatic analysis were confirmed by the low expression of H19, overexpression of Dkk4 and inhibited Wnt signaling observed in DOP rats. Subsequent in vitro cell assay further demonstrated that knockdown of H19 led to upregulation of Dkk4, and inhibition of Wnt signaling and osteogenic function in UMR106 cell. These effects can be greatly reversed after application of knocking down Dkk4.ConclusionOur findings demonstrated that low expression of H19, induced by mechanical unloading, leads to development of DOP through inhibition of Wnt signaling by promoting Dkk4 expression.
Genetic variability of Meloidogyne paranaensis populations and their aggressiveness to susceptible coffee genotypes
Authors: Santos M. F. A. , Correa V. R. , Peixoto J. R. , Mattos V. S. , Silva J. G. P. , Moita A. W. , Salgado S. M. L. , Castagnone‐Sereno P. , Carneiro R. M. D. G. 
Published: April 2017

Meloidogyne paranaensis is one of the most destructive root‐knot nematode (RKN) species parasitizing coffee in Brazil and in the Americas generally. The objectives of this study were to assess the genetic variability, aggressiveness and virulence of seven different M. paranaensis populations on susceptible and resistant Coffea spp. All seven RKN populations were identified by biochemical and molecular methods. Coffee seedlings were inoculated in the greenhouse, and the nematode reproduction factor was used to infer their reproduction on coffee genotypes. Phylogenetic studies showed a low genetic variability in M. paranaensis populations, regardless of the existence of three esterase phenotypes (Est P1, P2 and P2a), except for the population Est P2a from Guatemala, which is genetically different from other M. paranaensis populations from Brazil. The Est P2a and Est P2 (Herculândia, SP, Brazil) populations were the most aggressive on two susceptible C. arabica cultivars under greenhouse conditions. None of the M. paranaensis populations were virulent on resistant coffee genotypes, confirming their resistance to the seven M. paranaensis populations tested. The resistant coffee cultivars, namely Clone 14 INCAPER, Catuaí Vermelho × Amphillo MR2161 (E1 16‐5 III), Apoatã IAC 2258, Timor Hybrid UFV 408‐01 (E1 6‐6 II) and IPR 100, exhibited segregation for resistance in the ratio of 0%, 2.4%, 12%, 26% and 29%, respectively. These are promising results, because they validate resistance against several M. paranaensis populations in different Coffea spp. genetic resources, which can be used in breeding programmes or as rootstocks, such as Apoatã IAC 2258 and Clone 14 INCAPER.
Jean‐Luc Nancy and the “exit from religion”
Authors: Eaghll Tenzan 
Published: April 2017

AbstractThis article provides an introduction to Jean‐Luc Nancy's project on the “deconstruction of Christianity” by situating his work philosophically and historically. The author explains that Nancy's work on religion does not provide a new “theory” for the study of religion but shows how Western religious and philosophical foundations are caught up in a process of decomposition that has been brought about by Christianity. Strictly speaking, Nancy's work is not even an analysis of religion but builds upon the broader critique of metaphysical nihilism that thinkers like Nietzsche, Heidegger, and Derrida have taken up in the past.
How does burnout impact the three components of nursing professional commitment?
Authors: Chang Hao‐Yuan , Shyu Yea‐Ing Lotus , Wong May‐Kuen , Chu Tsung‐Lan , Lo Yuan‐Yu , Teng Ching‐I 
Published: April 2017

BackgroundWhile the impact of burnout on organisational commitment has been widely observed, its impact on nursing professional commitment has not previously been investigated. The literature has clarified that professional commitment has three distinct components: affective, continuance and normative.AimsThis study aims to investigate the relationships between burnout and the three components of nursing professional commitment.MethodsThis was a cross‐sectional study using questionnaires to collect data in one large medical centre. Responses from 571 nurses were used for regression analysis. Among the sampled nurses, 90.9% had <15 years of nursing experience. MBI‐HSS was used for measuring burnout. Three components of nursing professional commitment came from Meyer et al. (J Appl Psychol, 78, 1993 and 538) a formally validated instrument.ResultsAnalytical results indicated that burnout is negatively related to affective and normative professional commitment (B ≤ −0.09, p < 0.01), but not related to continuance professional commitment (B = 0.05, p > 0.05).Linking evidence to actionNurse managers aiming to improve nurses’ professional commitment should consider reducing nurses’ burnout, for example improving nursing optimism and reducing administrative tasks, as suggested by the literature.
Overexpression of a type‐I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase
Authors: Ma Dongming , Li Gui , Alejos‐Gonzalez Fatima , Zhu Yue , Xue Zhen , Wang Aimin , Zhang Hui , Li Xing , Ye Hechun , Wang Hong , Liu Benye , Xie De‐Yu 
Published: April 2017

SummaryWe recently characterized a gene–terpene network that is associated with artemisinin biosynthesis in self‐pollinated (SP) Artemisia annua, an effective antimalarial plant. We hypothesize that an alteration of gene expression in the network may improve the production of artemisinin and its precursors. In this study, we cloned an isopentenyl pyrophosphate isomerase (IPPI) cDNA, AaIPPI1, from Artemisia annua (Aa). The full‐length cDNA encodes a type‐I IPPI containing a plastid transit peptide (PTP) at its amino terminus. After the removal of the PTP, the recombinant truncated AaIPPI1 isomerized isopentenyl pyrophosphate (IPP) to dimethyl allyl pyrophosphate (DMAPP) and vice versa. The steady‐state equilibrium ratio of IPP/DMAPP in the enzymatic reactions was approximately 1:7. The truncated AaIPPI1 was overexpressed in the cytosol of the SP A. annua variety. The leaves of transgenic plants produced approximately 4% arteannuin B (g g−1, dry weight, dw) and 0.17–0.25% artemisinin (g g−1, dw), the levels of which were significantly higher than those in the leaves of wild‐type plants. In addition, transgenic plants showed an increase in artemisinic acid production of more than 1% (g g−1, dw). In contrast, isoprene formation was significantly reduced in transgenic plants. These results provide evidence that overexpression of AaIPPI1 in the cytosol can lead to metabolic alterations of terpenoid biosynthesis, and show that these transgenic plants have the potential to yield high production levels of arteannuin B as a new precursor source for artemisinin.
Detection and identification of platelet antibodies using a sensitive multiplex assay system–platelet antibody bead array
Authors: Metzner Krista , Bauer Julie , Ponzi Heather , Ujcich Allison , Curtis Brian R. 
Published: April 2017

BACKGROUNDTests for platelet‐specific antibodies are important in the diagnosis of immune platelet disorders. Monoclonal antibody glycoprotein capture assays have been the gold standards in platelet antibody detection for almost 30 years. However, such assays are complex and cumbersome to perform, which limits their routine use. We report the performance of a newly developed, easy to perform platelet antibody bead array (PABA) for the detection of platelet‐specific antibodies.STUDY DESIGN AND METHODSPABA is the equivalent of the monoclonal antigen capture enzyme‐linked immunosorbent assay (ELISA) (MACE) on a bead and instead with fluorescent detection of immunoglobulin (Ig)G platelet antibodies by Luminex. Antibodies against platelet glycoproteins (GP) GPIIb/IIIa, GPIb/IX, GPIa/IIa, GPIV, and class I human leukocyte antigen (HLA) could be detected in a patient's serum simultaneously in a single well of a microplate. Results from 80 patient samples and 20 normal donor samples were compared using PABA, MACE, and a commercial ELISA kit.RESULTSPABA detected all antibodies, with specificity for human platelet antigens (HPAs) HPA‐1a, HPA‐1b, HPA‐2a, HPA‐2b, HPA‐3a, HPA‐3b, HPA‐4a, HPA‐4b, HPA‐5a, HPA‐5b, HPA‐15b, and HLA. Overall, compared with MACE, the sensitivity and specificity of PABA were 99% and 97%, respectively, and both were significantly better than those of the commercial ELISA. PABA had greater analytic sensitivity than MACE for HPA‐1a, HPA‐3a, and HPA‐5b antibodies. In addition, PABA detected HPA‐5b and HPA‐3b antibodies that were missed by MACE. The overall false‐positive rate of PABA compared with MACE was 2.7%.CONCLUSIONSThe PABA is a rapid, highly sensitive and specific, multiplex bead‐based assay for detecting human platelet antibodies. Such a simple yet high‐throughput platform will facilitate practical, routine testing for the identification of platelet‐specific antibodies.