bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transdisciplinary Approaches in Assimilating Power and Diversity to Address Children’s Interface with the Law: A Case Study from India
Authors: Ramaswamy Sheila , Seshadri Shekhar , Bunders Joske 
Published: September 2024

AbstractMany children worldwide interact with the justice system, which presents a host of legal and practical problems. The substantial power differentials in children’s interface with the criminal justice system are skewed towards professionals from the judicial, protection and mental health fields. Since legal and judicial systems tend to be particularly patriarchal, paternalistic and hierarchical, they are poorly equipped to grasp the need for democratic and more fluid interactions in order to include marginalized and vulnerable witnesses, such as children. Drawing on the work of SAMVAD (Support, Advocacy & Mental Health Interventions for children in Vulnerable circumstances and Distress) and discussing transdisciplinary methodologies, this chapter reviews SAMVADs’ attempts to address the complex problems of child protection and mental health and law—both with children, and in intersectoral collaboration between service providers and stakeholders from the domains of child mental health and law. It does so with the specific aim to elicit lessons on how to overcome systematic and structural barriers and power asymmetries to bringing stakeholders together in a process of knowledge co-creation.
Roles and Competencies in Transdisciplinary Practices
Authors: Broerse Jacqueline E. W. , Zweekhorst Marjolein B. M. 
Published: September 2024

AbstractThis part of the edited volume explores how conceptualizations of transdisciplinary knowledge development processes, guided by transformative visions, materialize in engaged research practices. In this context, researchers grapple with navigating diverse roles and reflecting on their positionality. In addition, a reflexive, situated research practice demands a careful assembly and application of a wide variety of competencies to effectively implement and navigate these roles. By connecting theory-based approaches with empirical examples drawn from various transdisciplinary projects, this part of the book aims to cultivate a nuanced understanding of how roles and competencies contribute to shaping the emerging profile of the ‘transformative transdisciplinary researcher’.
Running a Real-World Lab to Stimulate Urban Food System Transformation: Navigating Between Different Actor Roles as a Transdisciplinary Researcher
Authors: den Boer Alanya C. L. 
Published: September 2024

AbstractReal-world Labs are increasingly used to catalyse systemic change by creating experimental spaces in which knowledge co-creation is stimulated among actors from the domains of research, business, policy, and civil society, known as the quadruple helix. However, relatively little attention is given to the challenge of facilitating such transformative Labs as a transdisciplinary researcher. In this chapter, Alanya den Boer reflects on her learning journey as a PhD researcher who conducted transdisciplinary research. She elaborates on the roles she adopted and the role synergies and conflicts that she faced during the course of a project in the field of food system transformation. The chapter ends with a critical discussion and a set of recommendations for the design and architecture of future projects that aim to stimulate system transformation via transdisciplinary Real-world labs approaches.
Transdisciplinarity for Transformation: What’s Next?
Authors: Regeer Barbara J. , Klaassen Pim , Broerse Jacqueline E. W. 
Published: September 2024

AbstractAs many of the chapters in this volume have illustrated, there are no single or easy answers to the question of ‘what is transdisciplinarity?’ and ‘how can I, through research or everyday inquiry, contribute to transformation?’. Everyone who was involved in this book project went on their own quest, their own journey, sometimes together with others, sometimes alone. In this concluding chapter, we loosely tie things together, ask ourselves what is next for Transdisciplinarity for Transformation by drafting an agenda for action, learning and research, and remind ourselves of the importance of diving into the unknown with curiosity and humility, without losing one’s ideals to make the world a more just, sustainable and safe place for all.
The Local Politics of Green Mobility in San Francisco and Copenhagen
Authors: Henderson Jason 
Published: September 2024

AbstractIn this chapter I consider how local politics shapes policies that promote or impede green mobility, including walking, cycling, and public transport organized around compact, high-density, car free and car-lite urbanism. I refer to municipal or city-scale politics and examine two aspirational green mobility cities, Copenhagen, Denmark, and San Francisco, California to help understand why green mobility transitions have been slow to realize in even the most promising localities. Despite different governing structures and histories, the politics of green mobility in both cities is remarkably similar. In both cities there are three broad factions demonstrating ideological difference over green mobility. (1) A left/progressive political faction promotes green mobility as a public good that government should actively promote. (2) A neoliberal faction, sometimes labeled “moderate” in both San Francisco and Copenhagen, also promotes green mobility, but with a market-oriented, deregulated hue, especially on housing and real estate. (3) A right/conservative politics of mobility expresses skepticism towards green mobility transitions and seeks to preserve car access to city spaces. I highlight how each mobility ideology is operationalized through debates over green mobility, including housing, in San Francisco and Copenhagen during 2022, two years after the Covid-19 Pandemic first locked-down cities.
On the Weierstraß form of infinite-dimensional differential algebraic equations
Authors: Erbay Mehmet , Jacob Birgit , Morris Kirsten 
Published: September 2024

AbstractThe solvability for infinite-dimensional differential algebraic equations possessing a resolvent index and a Weierstraß form is studied. In particular, the concept of integrated semigroups is used to determine a subset on which solutions exist and are unique. This information is later used for a important class of systems, namely, port-Hamiltonian differential algebraic equations.
A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies
Authors: Preciado David , Cardona-Galeano Wilson , Herrera-Ramírez Angie , Yepes Andrés F. 
Published: September 2024

AbstractColorectal cancer is one of the most incident and lethal cancers in the world. The search for new compounds to treat this disease is being motivated by the occurrence of side effects and the rising in the resistance to chemotherapy. We synthesized a new class of conjugates bearing quinazolinone and melatonin which were prepared in good yields (63–93%) through one-pot three-component approach. quinazolinone/melatonin conjugates were proved against SW480 human colorectal adenocarcinoma cells and non-malignant colonic cells (NCM460). The cytotoxic and antiproliferative activities were determined through the sulforhodamine B assay. Compounds 1f, 1g and 1i–l displayed the best activity, being hybrids 1i–l the most selective against malignant cells, causing either a cytostatic and/or cytotoxic effect with evident morphological changes. Moreover, a theoretical drug-like/pharmacokinetics/toxicological study suggested that the hit-promising compounds 1i and 1j would have a great chance to advance to further preclinical studies as anti-cancer therapeutic candidate for oral oncological management. Our study evidently identified the potency of these quinazolinone/melatonin hybrids to be a prototype drug for further investigations toward novel therapeutics treatments of colorectal cancer.
Endoscopic endonasal resection of olfactory tract hamartoma for pediatric epilepsy
Authors: Kundishora Adam J. , Reeves Benjamin C. , Lerner David K. , Storm Phillip B. , Prelack Marisa S. , Palmer James N. , Adappa Nithin D. , Kennedy Benjamin C. 
Published: September 2024

Abstract
Background
Non-hypothalamic glioneural hamartomas are rare entities known to cause medically refractory epilepsy. Olfactory bulb hamartomas, in particular, are exceptionally rare.

Methods
We describe a case of an olfactory bulb hamartoma that was surgically resected at our institution. We also performed a literature review of all glioneural hamartomas and discuss the clinical presentation, diagnosis, and management of these lesions.

Results
Herein, we present the unusual case of a typically developing 17-year-old boy with a near life-long history of drug-resistant epilepsy, found to have a 0.8 × 1.0 cm right olfactory bulb hamartoma. Endoscopic endonasal trans-cribriform resection of the lesion led to seizure freedom in the 6-month follow-up period (Engel class 1 outcome). Comprehensive literature review revealed only one other sporadic case, which was also successfully treated with total surgical resection.

Conclusions
Our case of an olfactory bulb hamartoma adds to the limited literature currently available, illustrating key clinical characteristics of these exceedingly rare lesions and outlining an effective, minimally invasive, and low-morbidity treatment strategy.
Cardiologists' perspective on termination of pacemaker therapy–an anonymous survey among cardiologists in Germany
Authors: Portig Irene , Hofacker Elena , Sommer Philipp , Volberg Christian , Seifart Carola 
Published: September 2024

Abstract
Background
The patient’s right to refuse pacemaker therapy is mentioned in the relevant European consensus statement but additional information is only available on deactivation of implantable cardioverter deactivator and not on other cardiac implantable electronic devices such as pacemakers. Therefore, we were interested in opinions, concerns and attitudes of cardiologists, who are the primary contact persons for such requests, since the number of patients asking for withdrawal of pacemaker therapy is likely to increase leaving cardiologists and healthcare professionals with a difficult medical but also ethical problem.

Methods
An anonymous questionnaire was sent to all German cardiology departments (N = 288).

Results
48% of cardiology departments responded by sending back 247 completed questionnaires. Most participating cardiologists were experienced when considering the duration of their professional activity. Almost all of the respondents regularly perform check-ups of pacemakers. The majority of cardiologists answering our questionnaire were prepared to deactivate a pacemaker upon patients’ request, and have done so. In pacemaker dependency, however, the willingness to withdraw decreases, even if death is imminent, for fear of causing distressing symptoms, sense of being responsible for patients possible immediate death, or fear of legal consequences.

Conclusions
The survey could clearly show that uncertainties remain among cardiologists dealing with a patient's wish for withdrawal, especially in cases of pacemaker dependency. We suggest that official statements of cardiologic societies in Europe are issued to clarify ethical, legal and practical aspects of pacemaker withdrawal.

Trial registration
Registered in the German Clinical Trials Register (DRKS00026168) on 30.08.2021.

Graphical Abstract
Correlation of preoperative sonographic staging and postoperative histopathologic staging in patients with invasive breast cancer
Authors: Mueller Carolin , Zimmermann Julia Sarah Maria , Radosa Marc Philipp , Hahn Anna Katharina , Kaya Askin Canguel , Huwer Sarah , Stotz Lisa , Wagenpfeil Gudrun , Radosa Christoph Georg , Solomayer Erich-Franz , Radosa Julia Caroline 
Published: September 2024

Abstract
Purpose
To assess the accuracy of preoperative sonographic staging in patients with primary invasive breast cancer.

Methods
We retrospectively analyzed a prospectively kept service database of patients with newly diagnosed, unifocal, cT1-3, invasive breast cancer. All patients were diagnosed at a single center institution between January 2013 and December 2021. Clinical T stage was assessed preoperatively by ultrasound and correlated with the definite postoperative pathologic T stage. Demographics, clinical and pathological characteristics were collected. Factors influencing accuracy, over- and underdiagnosis of sonographic staging were analyzed with multivariable regression analysis.

Results
A total of 2478 patients were included in the analysis. Median patients’ age was 65 years. 1577 patients (63.6%) had clinical T1 stage, 864 (34.9%) T2 and 37 (1.5%) T3 stage. The overall accuracy of sonography and histology was 76.5% (n = 1896), overestimation was observed in 9.1% (n = 225) of all cases, while underestimation occurred in 14.4% (n = 357) of all cases. Accuracy increased when clinical tumor stage cT was higher (OR 1.23; 95% CI 1.10–1.38, p ≤ 0.001). The highest accuracy was seen for patients with T2 stage (82.8%). The accuracy was lower in Luminal B tumors compared to Luminal A tumors (OR 0.71; 95% CI 0.59–0.87, p ≤ 0.001). We could not find any association between sonographic accuracy in HER2 positive patients, and demographic characteristics, or tumor-related factors.

Conclusion
Our unicentric study showed a high accuracy of sonography in predicting T stage, especially for tumors with clinical T2 stage. Tumor stage and biological tumor factors do affect the accuracy of sonographic staging.
Communication in oncology between healthcare providers, patients, the scientific community, and the media: recommendations from the Italian Association of Medical Oncology (AIOM)
Authors: Berardi Rossana , Parisi Alessandro , Maruzzo Marco , Bellani Marco , Beretta Giordano Domenico , Boldrini Mauro , Cavanna Luigi , Gori Stefania , Iannelli Elisabetta , Mancuso Anna Maria , Marinelli Massimiliano , Martinella Vera , Musso Michele , Papa Roberto , Russo Antonio , Tarantino Valentina , Taranto Mirella , Cinieri Saverio 
Published: September 2024

Abstract
Aim
To identify barriers between health and communication in oncology in order to promote the best possible practice. The areas of communication to be focused on are communication directly with the patient, communication within the scientific community, and communication with the media.

Material and methods
A working group including eminent experts from the national mass media, healthcare system, and patients’ advocacy has been established on behalf of the Italian Association of Medical Oncology (AIOM), with the aim of developing suitable recommendations for the best communication in oncology.
A literature search has been conducted selecting primary studies related to the best practices applied to communication in oncology. Subsequent to having identified the most representative statements, through a consensus conference using the RAND/University of California Los Angeles modified Delphi method, the panel evaluated the relevance of each statement to support useful strategies to develop effective communication between oncologist physicians and patients, communication within the scientific community, and communication with media outlets, including social media.

Results
A total of 292 statements have been extracted from 100 articles. Following an evaluation of relevance, it was found that among the 142 statements achieving the highest scores, 30 of these have been considered of particular interest by the panel.

Conclusions
This consensus and the arising document represent an attempt to strengthen the strategic alliance between key figures in communication, identifying high-impact recommendations for the management of communication in oncology with respect to patients, the wider scientific community, and the media.
A demand forecasting system of product categories defined by their time series using a hybrid approach of ensemble learning with feature engineering
Authors: Mejía Santiago , Aguilar Jose 
Published: September 2024

AbstractRetail companies face major problems in the estimation of their product’s future demand due to the high diversity of sales behavior that each good presents. Different forecasting models are implemented to meet the demand requirements for efficient inventory management. However, in most of the proposed works, a single model approach is applied to forecast all products, ignoring that some methods are better adapted for certain features of the demand time series of each product. The proposed forecasting system addresses this problem, by implementing a two-phase methodology that initially clusters the products with the application of an unsupervised learning approach using the extracted demand features of each good, and then, implements a second phase where, after a feature engineering process, a set of different forecasting methods are evaluated to identify those with best performs for each cluster. Finally, ensemble machine learning models are implemented using the top-performing models of each cluster to carry out the demand estimation. The results indicate that the proposed forecasting system improves the demand estimation over the single forecasting approaches when evaluating the R2, MSE, and MASE quality measures.
Prediction of COVID-19 cases using SIR and AR models: Tokyo-specific and nationwide application
Authors: Seki Tatsunori , Sakurai Tomoaki , Miyata Satoshi , Chujo Keisuke , Murata Toshiki , Inoue Hiroyasu , Ito Nobuyasu 
Published: September 2024

AbstractWith fast infectious diseases such as COVID-19, the SIR model may not represent the number of infections due to the occurrence of distribution shifts. In this study, we use simulations based on the SIR model to verify the prediction accuracy of new positive cases by considering distribution shifts. Instead of expressing the overall number of new positive cases in the SIR model, the number of new positive cases in a specific region is simulated, the expanded estimation ratio is expressed in the AR model, and these are multiplied to predict the overall number. In addition to the parameters used in the SIR model, we introduced parameters related to social variables. The parameters for the simulation were estimated daily from the data using approximate Bayesian computation (ABC). Using this method, the average absolute percent error in predicting the number of positive cases for the peak of the eighth wave (2022/12/22–12/28) for all of Japan was found to be 62.2% when using data up to two months before the peak and 6.2% when using data up to one month before the peak. Our simulations based on the SIR model reproduced the number of new positive cases across Japan and produced reasonable results when predicting the peak of the eighth wave.
“We live here because of nature”: transformation towards better flood resilience on small Danish islands
Authors: Baron Nina , Kongsager Rico 
Published: September 2024

AbstractClimate change is increasing the threat of flooding on small Danish islands. This article presents the results of a qualitative case study of flood risk perceptions and adaptive actions on three small Danish islands. The study explores how an empirical study of the islanders’ sense of place can contribute to a transformation towards better flood resilience. It finds that sense of place is closely connected to living close to nature, but also it highlights that the meaning given to ‘nature’ varies among the islanders. For some, nature is an uncultivated, wild landscape; for others, it is the present, cultural landscape. Another difference concerns whether the islands are described as a place to make a living or as a place to get away from everyday life. For some, farming and grazing are central to how they make a living on the islands; for others, these activities belong to the past. This insight into differences in the islanders’ sense of place contributes to understanding different perspectives regarding what is worth protecting, and what it is possible to protect from flooding, as well as why it is difficult for the islanders to reach agreement on the subject. This understanding has transformative potential, as it can give the islanders themselves, as well as authorities responsible for flood protection, a valuable insight into what drives and hinders actions to manage or reduce flood risk on small islands.
Current status of BAFF targeting immunotherapy in B-cell neoplasm
Authors: Tagami Nami , Yuda Junichiro , Goto Yasuyuki 
Published: September 2024

AbstractB-cell activating factor belonging to the TNF family (BAFF), also known as B-lymphocyte stimulator (BLyS), plays a crucial role in B-cell development. It has multiple receptors, including BCMA, TACI, and BAFF-R, with diverse roles in different cell types. BAFF induces B-cell proliferation and immunoglobulin secretion, and acts as a survival factor for immature, naive, and activated B cells. Consequently, BAFF-deficient mice often show suppressed humoral responses, while BAFF-overexpressing mice show the higher number of mature B cells and may develop autoimmune-like manifestations and B-cell lymphoproliferative diseases. Elevated BAFF levels are also associated with various hematological malignancies, and its expression correlates with disease progression in some cases. Therefore, BAFF-targeted therapies, such as belimumab, atacicept, and tabalumab, are being explored in clinical trials for conditions like chronic lymphocytic leukemia (CLL) and multiple myeloma. Belimumab, an anti-BAFF monoclonal antibody, is being investigated in combination with rituximab/venetoclax for CLL. Atacicept, a decoy receptor for BAFF and APRIL, showed tolerability in a phase 1b trial for CLL. Tabalumab, another monoclonal antibody targeting BAFF, did not demonstrate significant efficacy in a phase 2 study for relapsed/refractory multiple myeloma. BAFF ligand-based CAR-T cells are designed to target BAFF receptors and show promise in preclinical studies, particularly for B-cell malignancies. The review emphasizes the importance of understanding the roles of BAFF and its receptors in the microenvironment of hematologic malignancies. Targeting BAFF and its receptors presents potential therapeutic avenues, and ongoing clinical trials provide valuable insights.
Batch Electrocoagulation Process for the Removal of High Colloidal Clay from Open-Cast Coal Mine Water Using Al and Fe Electrodes
Authors: Abfertiawan Muhammad Sonny , Syafila Mindriany , Handajani Marisa , Hasan Faiz , Oktaviani Hanifah , Gunawan Firman , Djali dan Febriwiadi 
Published: September 2024

AbstractOpen-cast coal mining operations can produce water with high amounts of total suspended solids (TSS). We tested the use of electrocoagulation for the removal of colloidal clay from mine water. Monopolar batch electrocoagulation was performed at the laboratory scale using Al and Fe electrodes and varying the DC current (0.5, 1, and 2 A) and contact time (15, 30, and 45 min). Aluminum electrode electrocoagulation with a current of 2 A and a contact time of 15 min had the greatest TSS removal efficiency (99%), with concentrations decreasing from 5,400 to 23 mg/L. The greatest removal (98 and 99%, respectively) was obtained using an Al electrode with an electric current of 0.5 and 1 A, with 30 min of contact time. With an Fe electrode, the greatest efficiency was achieved with a current of 2 A and a contact time of 30 min. The TSS removal efficiency reached 98% while the concentration dropped to 66 mg/L, followed by 89% and 95% for the 0.5 A-45 min and 1 A-15 min variations, respectively.