bluuebunny/crossref_metadata_2025_split huggingface dataset:
New actions of an old friend: perivascular adipose tissue's adrenergic mechanisms
Authors: Ayala‐Lopez Nadia , Watts Stephanie W 
Published: November 2016

AbstractThe revolutionary discovery in 1991 by Soltis and Cassis that perivascular adipose tissue (PVAT) has an anti‐contractile effect changed how we think about the vasculature. Most experiments on vascular pharmacology begin by removing the fat surrounding vessels. Thus, PVAT was thought to have a minor role in vascular function and its presence was just for structural support. The need to rethink PVAT's role was precipitated by observations that obesity carries a high cardiovascular risk and PVAT dysfunction is associated with obesity. PVAT is a vascular‐adipose organ that has intimate connections with the nervous and immune system. A complex world of physiology resides in PVAT, including the presence of an ‘adrenergic system’ that is able to release, take up and metabolize noradrenaline. Adipocytes, stromal vascular cells and nerves within PVAT contain components that make up this adrenergic system. Some of the great strides in PVAT research came from studying adipose tissue as a whole. Adipose tissue has many roles and participates in regulating energy balance, energy stores, inflammation and thermoregulation. However, PVAT is dissimilar from non‐PVAT adipose tissues. PVAT is intimately connected with the vasculature, which is what makes its role in body homeostasis unique. The adrenergic system within PVAT may be an integral link connecting the effects of obesity with the vascular dysfunction observed in obesity‐associated hypertension, a condition in which the sympathetic nervous system has a significant role. This review will explore what is known about the adrenergic system in adipose tissue and PVAT, plus the translational importance of these findings.Linked ArticlesThis article is part of a themed section on Molecular Mechanisms Regulating Perivascular Adipose Tissue – Potential Pharmacological Targets? To view the other articles in this section visithttp://onlinelibrary.wiley.com/doi/10.1111/bph.v174.20/issuetoc
Sensory‐based conservation of seabirds: a review of management strategies and animal behaviours that facilitate success
Authors: Friesen Megan R. , Beggs Jacqueline R. , Gaskett Anne C. 
Published: November 2016

ABSTRACTSensory‐based conservation harnesses species' natural communication and signalling behaviours to mitigate threats to wild populations. To evaluate this emerging field, we assess how sensory‐based manipulations, sensory mode, and target taxa affect success. To facilitate broader, cross‐species application of successful techniques, we test which behavioural and life‐history traits correlate with positive conservation outcomes. We focus on seabirds, one of the world's most rapidly declining groups, whose philopatry, activity patterns, foraging, mate choice, and parental care behaviours all involve reliance on, and therefore strong selection for, sophisticated sensory physiology and accurate assessment of intra‐ and inter‐species signals and cues in several sensory modes. We review the use of auditory, olfactory, and visual methods, especially for attracting seabirds to newly restored habitat or deterring birds from fishing boats and equipment. We found that more sensory‐based conservation has been attempted with Procellariiformes (tube‐nosed seabirds) and Charadriiformes (e.g. terns and gulls) than other orders, and that successful outcomes are more likely for Procellariiformes. Evolutionary and behavioural traits are likely to facilitate sensory‐based techniques, such as social attraction to suitable habitat, across seabird species. More broadly, successful application of sensory‐based conservation to other at‐risk animal groups is likely to be associated with these behavioural and life‐history traits: coloniality, philopatry, nocturnal, migratory, long‐distance foraging, parental care, and pair bonds/monogamy.
Out of Reach, Out of Mind? Infants’ Comprehension of References to Hidden Inaccessible Objects
Authors: Osina Maria A. , Saylor Megan M. , Ganea Patricia A. 
Published: November 2016

This study investigated the nature of infants’ difficulty understanding references to hidden inaccessible objects. Twelve‐month‐old infants (N = 32) responded to the mention of objects by looking at, pointing at, or approaching them when the referents were visible or accessible, but not when they were hidden and inaccessible (Experiment I). Twelve‐month‐olds (N = 16) responded robustly when a container with the hidden referent was moved from a previously inaccessible position to an accessible position before the request, but failed to respond when the reverse occurred (Experiment II). This suggests that infants might be able to track the hidden object's dislocations and update its accessibility as it changes. Knowing the hidden object is currently inaccessible inhibits their responding. Older, 16‐month‐old (N = 17) infants’ performance was not affected by object accessibility.
Esthetic Assessment of Implants Placed into Fresh Extraction Sockets for Single‐Tooth Replacements Using a Flapless Approach
Authors: Kolerman Roni , Mijiritsky Eitan , Barnea Eitan , Dabaja Areeje , Nissan Joseph , Tal Haim 
Published: November 2016

AbstractBackgroundTo validate the concept of immediate implant placement and nonfunctional loading for use in the esthetically sensitive anterior maxilla, clinical trials should ideally include objective esthetic criteria.PurposeThis study analyzed procedural results as graded by the pink esthetic score and white esthetic score (PES/WES).MethodsThirty‐nine suitable patients (mean follow‐up 44.82 ± 28 months) were evaluated.ResultsThirty‐eight implants fulfilled stringent criteria for successful osseointegration: absence of peri‐implant radiolucency, implant mobility, suppuration, and pain. The mean total PES/WES was 15.50 ± 2.67 (range: 10–20). The mean total PES of 7.92 ± 1.60 (range: 5–10) indicated favorable overall peri‐implant soft‐tissue conditions. Root convexity and texture (1.63 ± 0.54) and curvature of the facial mucosa (1.68 ± 0.47) and distal papilla (1.66 ± 0.48) had the highest mean values, whereas acceptable levels of facial tissue (1.53 ± 0.73) and mesial papilla (1.42 ± 0.64) were the most difficult to fully achieve. The mean mesial and distal bone loss at data collection was, was 1.19 ± 0.54 and 1.15 ± 0.51, respectively. Periodontal disease severity (advanced chronic and aggressive periodontitis) was significantly associated with a low total PES (p = .048).ConclusionsObjective PES/WES assessment validated immediate anterior maxillary single‐tooth replacement and restoration as being a successful and esthetically predictable treatment modality in sites where the buccal bone had been preserved during the extraction at 1 year of follow‐up.
Fragmentation affects plant community composition over time
Authors: Collins C. D. , Banks‐Leite C. , Brudvig L. A. , Foster B. L. , Cook W. M. , Damschen E. I. , Andrade A. , Austin M. , Camargo J. L. , Driscoll D. A. , Holt R. D. , Laurance W. F. , Nicholls A. O. , Orrock J. L. 
Published: November 2016

Habitat fragmentation can lead to major changes in community composition, but little is known about the dynamics of these changes, or how community trajectories are affected by the initial state of habitat maturity. We use four landscape‐scale experiments from different biogeographic regions to understand how plant community composition responds to fragmentation over decades. Within each experiment, we consider first whether plant communities in the most‐fragmented treatments diverge in composition from plant communities in the least‐fragmented treatments. Second, because communities embedded in different fragments may become more similar to one another over time (biotic homogenization), we asked whether beta diversity – compositional variation across space – declines among fragments over time. Third, we assessed whether fragmentation alters the degree to which temporal change in fragmented landscapes is due to ordered species losses and gains (nestedness) versus species replacements (turnover). For each of these three questions, we contrasted patterns of compositional change in mature communities following fragmentation (disassembly; n = 2 experiments) with patterns in newly‐developing plant communities in fragments cleared of vegetation (assembly; n = 2 experiments).In the two studies where communities were disassembling, community composition in the most‐fragmented habitats diverged from that in least‐fragmented habitats. Beta diversity within a fragmentation treatment did not change over time at any of the four sites. In all four experiments, temporal patterns of compositional change were due mostly to species turnover, although nestedness played a role in the least‐fragmented sites in two of the studies. Overall, the impacts on community composition varied among landscape experiments, and divergence may have been affected by the maturity of the plant community. Future comparisons across ecosystems that account for species identities (vs simply richness) will be critical for predicting the effects of fragmentation, managing mature plant communities in remnants, and restoring plant communities where habitat has been lost.
Parthenogenesis did not consistently evolve in insular populations of Ischnura hastata (Odonata, Coenagrionidae)
Authors: LORENZO‐CARBALLA M. OLALLA , HASSALL CHRISTOPHER , ENCALADA ANDREA C. , SANMARTÍN‐VILLAR IAGO , TORRES‐CAMBAS YUSDIEL , CORDERO‐RIVERA ADOLFO 
Published: November 2016

1. The evolutionary advantages that have driven the evolution of sex are still very much debated, and a number of benefits of parthenogenesis over sexual reproduction have been proposed. In particular, parthenogenetic individuals are thought to exhibit higher probabilities of establishment following arrival in new, isolated habitats such as islands.2. One notable example of parthenogenesis occurring in islands is the damselfly Ischnura hastata, an American species that has colonised the Azores archipelago, where the populations consist only of females. This is the only known example of parthenogenesis within the insect order Odonata.3. Here, two island populations of I. hastata were studied, one in the Galapagos and one in Cuba, to test whether island colonisation is consistently associated with parthenogenesis in this species. Field capture–mark–recapture studies and laboratory rearing of field‐collected eggs were undertaken in both areas.4. Sex ratios in the field were found to be heavily female‐biased among mature individuals; however, fertility rates of field‐collected eggs were high, and the sex ratios in the laboratory did not differ from 1 : 1. Data from laboratory rearing showed that shorter larval development times and shorter adult life spans in males result in protandry, which might explain the skewed sex ratios in the field.5. These findings are consistent with sex differences in key demographic parameters which could predispose I. hastata to parthenogenesis. However, the Azores population of I. hastata remains the only documented case of asexual reproduction in this insect group.
Temporal behavior of seizures and interictal bursts in prolonged intracranial recordings from epileptic canines
Authors: Ung Hoameng , Davis Kathryn A. , Wulsin Drausin , Wagenaar Joost , Fox Emily , McDonnell John J. , Patterson Ned , Vite Charles H. , Worrell Gregory , Litt Brian 
Published: November 2016

SummaryObjectiveEpilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic intracranial recordings in canine epilepsy.MethodsContinuous, yearlong intracranial electroencephalography (iEEG) recordings from four dogs with naturally occurring epilepsy were analyzed for seizures and interictal bursts. Following automated detection and clinician verification of interictal bursts and seizures, temporal trends of seizures, burst count, and burst–burst similarities were determined. One dog developed status epilepticus, the recordings of which were also investigated.ResultsMultiple seizure types, determined by onset channels, were observed in each dog, with significant temporal variation between types. The first 14 days of invasive recording, analogous to the average duration of clinical invasive recordings in humans, did not capture the entirety of seizure types. Seizures typically occurred in clusters, and isolated seizures were rare. The count and dynamics of interictal bursts form distinct groups and do not stabilize until several weeks after implantation.SignificanceThere is significant temporal variability in seizures and interictal bursts after electrode implantation that requires several weeks to reach steady state. These findings, comparable to those reported in humans implanted with the NeuroPace Responsive Neurostimulator System (RNS) device, suggest that transient network changes following electrode implantation may need to be taken into account when interpreting or analyzing iEEG during evaluation for epilepsy surgery. Chronic, ambulatory iEEG may be better suited to accurately map epileptic networks in appropriate individuals.
Lamotrigine and levetiracetam exert a similar modulation of TMS‐evoked EEG potentials
Authors: Premoli Isabella , Biondi Andrea , Carlesso Sara , Rivolta Davide , Richardson Mark P. 
Published: November 2016

SummaryObjectiveAntiepileptic drug (AED) treatment failures may occur because there is insufficient drug in the brain or because of a lack of relevant therapeutic response. Until now it has not been possible to measure these factors. It has been recently shown that the combination of transcranial magnetic stimulation and electroencephalography (TMS‐EEG) can measure the effects of drugs in healthy volunteers. TMS‐evoked EEG potentials (TEPs) comprise a series of positive and negative deflections that can be specifically modulated by drugs with a well‐known mode of action targeting inhibitory neurotransmission. Therefore, we hypothesized that TMS‐EEG can detect effects of two widely used AEDs, lamotrigine and levetiracetam, in healthy volunteers.MethodsFifteen healthy subjects participated in a pseudo‐randomized, placebo‐controlled, double‐blind, crossover design, using a single oral dose of lamotrigine (300 mg) and levetiracetam (3,000 mg). TEPs were recorded before and 120 min after drug intake, and the effects of drugs on the amplitudes of TEP components were statistically evaluated.ResultsA nonparametric cluster‐based permutation analysis of TEP amplitudes showed that AEDs both increased the amplitude of the negative potential at 45 msec after stimulation (N45) and suppressed the positive peak at 180 msec (P180). This is the first demonstration of AED‐induced modulation of TMS‐EEG measures.SignificanceDespite the different mechanism of action that lamotrigine and levetiracetam exert at the molecular level, both AEDs impact the TMS‐EEG response in a similar way. These TMS‐EEG fingerprints observed in healthy subjects are candidate predictive markers of treatment response in patients on monotherapy with lamotrigine and levetiracetam.
Fitting fatigue data with a bi‐conditional model
Authors: Cova M , Tovo R 
Published: November 2016

AbstractThe formulation of a probability‐stress‐life (P‐S‐N) curve is a necessary step beyond the basic S‐N relation when dealing with reliability. This paper presents a model, relevant to materials that exhibits a fatigue limit, which considers the number of cycles to failure and the occurrence of the failure itself as statistically independent events, described with different distributions and/or different degree of scatter. Combining these two as a parallel system leads to the proposed model. In the case where the S‐N relation is a Basquin's law, the formulations of the probability density function, cumulative distribution function, quantiles, parameter and quantile confidence interval are presented in a procedure that allows practically any testing strategy.The result is a flexible model combined with the tools that deliver a wide range of information needed in the design phase. Finally, an extension to include static strength and applicability to fatigue crack growth and defects‐based fatigue approach are presented.
Experimental and analytical investigation of fatigue crack propagation of T‐welded joints considering the effect of boundary condition
Authors: Sun D , Gan J , Wang Z , Luo P , Wu W 
Published: November 2016

AbstractT‐welded joints are commonly employed in ship and ocean structures. The fatigue failure of structure components subjected to cyclic loading always occurs in T‐welded joints because of the metallurgical differences, tensile residual stress fields and stress concentrations. The former researches about T‐welded joints fatigue have in common that the boundary condition needs to be taken into account as an influencing parameter to predict the crack propagation during cyclic loading. In this paper, the crack growth behaviour in T‐welded joint processed with Q345D steel (Pingxiang Iron & Steel Co., Ltd, Hukou, Jiangxi Province in China) under the fatigue loading was analysed via analytical model and verified via experiment. The results show that the influence of boundary condition should be considered in T‐welded joint structure during crack propagation in weld toe area. The correction factor concerning the effect of boundary condition and modified Paris' equation was proposed according to the experimental results and verified by the following repeated experiments.
Foreign Language Writing Fellows Programs: A Model for Improving Advanced Writing Skills
Authors: Snyder Delys Waite , Nielson Rex P. , Kurzer Kendon 
Published: November 2016

AbstractWithin the growing field of scholarly literature on foreign language (FL) writing pedagogy, few studies have addressed pedagogical questions regarding the teaching of writing to advanced language learners. Writing fellows peer tutoring programs, although typically associated with first language writing instruction, likely can benefit and support advanced language students learning to write in FL contexts. Using a mixed‐methods approach, the authors compared two sections of an upper‐division Portuguese literature class that employed writing fellows tutors with two sections that did not. Data suggest that incorporating writing fellows into FL contexts affected how students learned to write: (1) the papers of students who worked with writing fellows exhibited more developed thought, (2) students who worked with writing fellows employed more successful writing strategies, and (3) students who worked with writing fellows exhibited changes in their writing processes for future writing assignments. These conclusions suggest that the inclusion of peer tutors such as writing fellows may be an effective pedagogical practice for teaching writing to advanced FL learners.
Precision wildlife medicine: applications of the human‐centred precision medicine revolution to species conservation
Authors: Whilde Jenny , Martindale Mark Q. , Duffy David J. 
Published: November 2016

AbstractThe current species extinction crisis is being exacerbated by an increased rate of emergence of epizootic disease. Human‐induced factors including habitat degradation, loss of biodiversity and wildlife population reductions resulting in reduced genetic variation are accelerating disease emergence. Novel, efficient and effective approaches are required to combat these epizootic events. Here, we present the case for the application of human precision medicine approaches to wildlife medicine in order to enhance species conservation efforts. We consider how the precision medicine revolution, coupled with the advances made in genomics, may provide a powerful and feasible approach to identifying and treating wildlife diseases in a targeted, effective and streamlined manner. A number of case studies of threatened species are presented which demonstrate the applicability of precision medicine to wildlife conservation, including sea turtles, amphibians and Tasmanian devils. These examples show how species conservation could be improved by using precision medicine techniques to determine novel treatments and management strategies for the specific medical conditions hampering efforts to restore population levels. Additionally, a precision medicine approach to wildlife health has in turn the potential to provide deeper insights into human health and the possibility of stemming and alleviating the impacts of zoonotic diseases. The integration of the currently emerging Precision Medicine Initiative with the concepts of EcoHealth (aiming for sustainable health of people, animals and ecosystems through transdisciplinary action research) and One Health (recognizing the intimate connection of humans, animal and ecosystem health and addressing a wide range of risks at the animal–human–ecosystem interface through a coordinated, collaborative, interdisciplinary approach) has great potential to deliver a deeper and broader interdisciplinary‐based understanding of both wildlife and human diseases.
Forests growing under dry conditions have higher hydrological resilience to drought than do more humid forests
Authors: Helman David , Lensky Itamar M. , Yakir Dan , Osem Yagil 
Published: November 2016

AbstractMore frequent and intense droughts are projected during the next century, potentially changing the hydrological balances in many forested catchments. Although the impacts of droughts on forest functionality have been vastly studied, little attention has been given to studying the effect of droughts on forest hydrology. Here, we use the Budyko framework and two recently introduced Budyko metrics (deviation and elasticity) to study the changes in the water yields (rainfall minus evapotranspiration) of forested catchments following a climatic drought (2006–2010) in pine forests distributed along a rainfall gradient (P = 280–820 mm yr−1) in the Eastern Mediterranean (aridity factor = 0.17–0.56). We use a satellite‐based model and meteorological information to calculate the Budyko metrics. The relative water yield ranged from 48% to 8% (from the rainfall) in humid to dry forests and was mainly associated with rainfall amount (increasing with increased rainfall amount) and bedrock type (higher on hard bedrocks). Forest elasticity was larger in forests growing under drier conditions, implying that drier forests have more predictable responses to drought, according to the Budyko framework, compared to forests growing under more humid conditions. In this context, younger forests were shown more elastic than older forests. Dynamic deviation, which is defined as the water yield departure from the Budyko curve, was positive in all forests (i.e., less‐than‐expected water yields according to Budyko's curve), increasing with drought severity, suggesting lower hydrological resistance to drought in forests suffering from larger rainfall reductions. However, the dynamic deviation significantly decreased in forests that experienced relatively cooler conditions during the drought period. Our results suggest that forests growing under permanent dry conditions might develop a range of hydrological and eco‐physiological adjustments to drought leading to higher hydrological resilience. In the context of predicted climate change, such adjustments are key factors in sustaining forested catchments in water‐limited regions.