bluuebunny/crossref_metadata_2025_split huggingface dataset:
Continental-scale associations of Arabidopsis thaliana phyllosphere members with host genotype and drought
Authors: Karasov Talia L. , Neumann Manuela , Leventhal Laura , Symeonidi Efthymia , Shirsekar Gautam , Hawks Aubrey , Monroe Grey ,   Pathodopsis Team, Barragán A. Cristina , Bezrukov Ilja , Friedemann Claudia , González Hernando Alba , Habring Anette , Hildebrandt Julia , Kersten Sonja , Lang Patricia , Latorre Sergio M. , Lucke Miriam , Lundberg Derek S. , Lutz Ulrich , Paul Fiona , Rabanal Fernando A. , Regalado Julian , Srikant Thanvi , Waithaka Bridgit , Wibowo Anjar T. , Yuan Wei , Exposito-Alonso Moisés , Bergelson Joy , Weigel Detlef , Schwab Rebecca 
Published: September 2024

AbstractPlants are colonized by distinct pathogenic and commensal microbiomes across different regions of the globe, but the factors driving their geographic variation are largely unknown. Here, using 16S ribosomal DNA and shotgun sequencing, we characterized the associations of the Arabidopsis thaliana leaf microbiome with host genetics and climate variables from 267 populations in the species’ native range across Europe. Comparing the distribution of the 575 major bacterial amplicon variants (phylotypes), we discovered that microbiome composition in A. thaliana segregates along a latitudinal gradient. The latitudinal clines in microbiome composition are predicted by metrics of drought, but also by the spatial genetics of the host. To validate the relative effects of drought and host genotype we conducted a common garden field study, finding 10% of the core bacteria to be affected directly by drought and 20% to be affected by host genetic associations with drought. These data provide a valuable resource for the plant microbiome field, with the identified associations suggesting that drought can directly and indirectly shape genetic variation in A. thaliana via the leaf microbiome.
Probiotics and magnesium orotate for the treatment of major depressive disorder: a randomised double blind controlled trial
Authors: Strodl Esben , Bambling Matthew , Parnam Sophie , Ritchie Gabrielle , Cramb Susanna , Vitetta Luis 
Published: September 2024

AbstractFollowing on from our pilot studies, this study aimed to test the efficacy of a combination of probiotics (Lactobacillus acidophilus, Bifidobacterium bifidum, Streptococcus thermophilus), magnesium orotate and coenzyme 10 for the treatment of major depressive disorder (MDD) through a double-blind placebo controlled clinical trial. The participants were 120 adults diagnosed with MDD randomised to daily oral administration, over 8 weeks, of either the intervention or placebo, with a 16-week follow-up period. Intent-to-treat analysis found a significantly lower frequency of the presence of a major depressive episode in the intervention group compared with placebo at the end of the 8-week treatment phase, with no difference between the two conditions at 8-week follow-up. Both the categorical and continuous measure of depressive symptoms showed a significant difference between the two conditions at 4 weeks, but not 8 and 16 weeks. The secondary end-point was demonstrated with an overall reduction in self-rated symptoms of anxiety and stress in the active treatment group compared with placebo. These findings suggest that the combination of probiotics, magnesium orotate and coenzyme 10 may be an effective treatment of MDD over an 8-week period.
PROTAC-mediated conditional degradation of the WRN helicase as a potential strategy for selective killing of cancer cells with microsatellite instability
Authors: Tejwani Vikram , Carroll Thomas , Macartney Thomas , Bandau Susanne , Alabert Constance , Saredi Giulia , Toth Rachel , Rouse John 
Published: September 2024

AbstractMultiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prove in clinical trials, and the likelihood of tumours developing resistance to WRN inhibitors, alternative strategies for impeding WRN function are needed. Proteolysis-targeting chimeras (PROTACs) are heterobifunctional small molecules that target specific proteins for degradation. Here, we engineered the WRN locus so that the gene product is fused to a bromodomain (Bd)-tag, enabling conditional WRN degradation with the AGB-1 PROTAC specific for the Bd-tag. Our data revealed that WRN degradation is highly toxic in MSI but not MSS cell lines. In MSI cells, WRN degradation caused G2/M arrest, chromosome breakage and ATM kinase activation. We also describe a multi-colour cell-based platform for facile testing of selective toxicity in MSI versus MSS cell lines. Together, our data show that a degrader approach is a potentially powerful way of targeting WRN in MSI cancers and paves the way for the development of WRN-specific PROTAC compounds.
Fuzzy inference system enabled neural network feedforward compensation for position leap control of DC servo motor
Authors: Huang Zhiwen , Yan Yuting , Zhu Yidan , Shao Jiajie , Zhu Jianmin , Fang Dianjun 
Published: September 2024

AbstractTo improve dynamic performance and steady-state accuracy of position leap control of the direct current (DC) servo motor, a fuzzy inference system (FIS) enabled artificial neural network (ANN) feedforward compensation control method is proposed in this study. In the method, a proportional-integral-derivative (PID) controller is used to generate the baseline control law. Then, an ANN identifier is constructed to online learn the reverse model of the DC servo motor system. Meanwhile, the learned parameters are passed in real-time to an ANN compensator to provide feedforward compensation control law accurately. Next, according to system tracking error and network modeling error, an FIS decider consisting of an FI basic module and an FI finetuning module is developed to adjust the compensation quantity and prevent uncertain disturbance from undertrained ANN adaptively. Finally, the feasibility and efficiency of the proposed method are verified by the tracking experiments of step and square signals on the DC servo motor testbed. Experimental results show that the proposed FIS-enabled ANN feedforward compensation control method achieves lower overshoot, faster adjustment, and higher precision than other comparative control methods.
Developing survival prediction models in colorectal cancer using epigenome-wide DNA methylation data from whole blood
Authors: Fan Ziwen , Edelmann Dominic , Yuan Tanwei , Köhler Bruno Christian , Hoffmeister Michael , Brenner Hermann 
Published: September 2024

AbstractWhile genome-wide association studies are valuable in identifying CRC survival predictors, the benefit of adding blood DNA methylation (blood-DNAm) to clinical features, including the TNM system, remains unclear. In a multi-site population-based patient cohort study of 2116 CRC patients with baseline blood-DNAm, we analyzed survival predictions using eXtreme Gradient Boosting with a 5-fold nested leave-sites-out cross-validation across four groups: traditional and comprehensive clinical features, blood-DNAm, and their combination. Model performance was assessed using time-dependent ROC curves and calibrations. During a median follow-up of 10.3 years, 1166 patients died. Although blood-DNAm-based predictive signatures achieved moderate performances, predictive signatures based on clinical features outperformed blood-DNAm signatures. The inclusion of blood-DNAm did not improve survival prediction over clinical features. M1 stage, age at blood collection, and N2 stage were the top contributors. Despite some prognostic value, incorporating blood DNA methylation did not enhance survival prediction of CRC patients beyond clinical features.
No evidence of increased forest loss from a mining rush in Madagascar’s eastern rainforests
Authors: Devenish Katie , Willcock Simon , Goodenough Kathryn M. , Heriniaina Rio , Rakotonarivo O. Sarobidy , Jones Julia P. G. 
Published: September 2024

AbstractArtisanal and small-scale mining is an important livelihood activity in many biodiversity hotspots. There is substantial international concern about the negative impact of artisanal and small-scale mining on biodiversity, yet in most places this remains poorly understood. We explore the impacts of a high-profile mining rush: the 2016 sapphire rush at Bemainty, Eastern Madagascar, where tens of thousands of miners descended on a protected forest. Media coverage claimed the rush caused hundreds of hectares of deforestation and threatened lemur populations. Using the synthetic control method to estimate counterfactual outcomes, we find no evidence that mining increased forest loss or degradation. Supported by informal interviews and a lemur survey, we argue that mining at Bemainty had limited impacts on the surrounding forest, relative to other threats. Our results highlight the heterogeneity of environmental impacts from artisanal and small-scale mining and emphasize the need for more robust evaluations to inform context-specific policies.
Mixtures of organic micropollutants exacerbated in vitro neurotoxicity of prymnesins and contributed to aquatic toxicity during a toxic algal bloom
Authors: Escher Beate I. , Ahlheim Jörg , Böhme Alexander , Borchardt Dietrich , Brack Werner , Braun Georg , Colbourne John K. , Dann Janek Paul , Gessner Joern , Jahnke Annika , König Maria , Klüver Nils , Krauss Martin , Lee Jungeun , Li Xiaojing , Lips Stefan , Orsini Luisa , Rinke Karsten , Schmitt-Jansen Mechthild , Scholz Stefan , Schulze Tobias , Spahr Stephanie , Ulrich Nadin , Weitere Markus , Varga Elisabeth 
Published: September 2024

AbstractPrymnesins produced by an algal bloom of Prymnesium parvum led to the death of several hundred tons of freshwater fish in the Oder River in summer 2022. We investigated effects on aquatic life and human cell lines from exposure to extracts of contaminated water collected during the fish kill. We detected B-type prymnesins and >120 organic micropollutants. The micropollutants occurred at concentrations that would cause the predicted mixture risk quotient for aquatic life to exceed the acceptable threshold. Extracts of water and filters (biomass and particulates) induced moderate effects in vivo in algae, daphnids and zebrafish embryos but caused high effects in a human neuronal cell line indicating the presence of neurotoxicants. Mixture toxicity modelling demonstrated that the in vitro neurotoxic effects were mainly caused by the detected B-type prymnesins with minor contributions by organic micropollutants. Complex interactions between natural and anthropogenic toxicants may underestimate threats to aquatic ecosystems.
Systematic re-review of WASH trials to assess women’s engagement in intervention delivery and research activities
Authors: Caruso Bethany A. , Ballard April M. , Sobolik Julia , Patrick Madeleine , Dsouza Janice , Sinharoy Sheela S. , Cumming Oliver , Wolf Jennyfer , Ray Isha 
Published: September 2024

AbstractWater, sanitation and hygiene (WASH) interventions significantly reduce health risks in low- and middle-income countries. Many rely on women, but the extent of women’s engagement remains undocumented. Here we conducted a re-review of papers from two systematic reviews that assessed the effectiveness of water, sanitation and/or handwashing with soap interventions on diarrhoeal disease and acute respiratory infections to assess women’s roles in WASH research and intervention activities. A total of 133 studies were included. Among studies that specified gender, women were the most sought-after group for engagement in research (n = 91/132; 68.9%) and intervention (n = 49/120; 40.8%) activities. Reporting time burden for research (n = 1; 1%) and intervention activities (n = 3; 2.5%) was rare. All interventions were classified as gender unequal (36.7%) or gender unaware (63.3%) according to the World Health Organization Gender Responsiveness Assessment Scale, indicating exploitative engagement. Women play a critical but instrumentalized role in WASH, and both research and interventions need to change to enable, and not hinder, gender equality.
Investigating energy transfer in lanthanide-doped double perovskites exhibiting visible and near-infrared emission
Authors: Cao Jueran , Tang Baoling , Li Tianrui , Wei Mingkai , Zhang Xuejie , Zheng Mingtao , Dong Bin , Li Xinming , Cong Yan , Molokeev Maxim S. , Lei Bingfu 
Published: September 2024

Sb3+–Tm3+ co-doped Cs2NaInCl6 double perovskite that emits in the near-infrared (NIR) region at 1220 nm was synthesized and studied. Its application in visible and near-infrared pc-LEDs for optoelectronic devices was investigated.
Piriformis preserving posterior approach STAR for primary and primary complex total hip arthroplasty: Excellent safety and efficacy in a single blinded prospective single surgeon cohort of 522 patients with a mean follow-up of 2 years
Authors: Kenanidis Eustathios , Pegios Vasileios F. , Tsamoura Eleni , Milonakis Nikolaos , Tsiridis Eleftherios 
Published: September 2024

Introduction: STAR (Superior Transverse Anatomic Reconstruction), a piriformis-preserving posterior approach, has not been extensively studied. Our study aimed to assess the STAR approach’s safety and efficacy by recording postoperative complication rates and measuring implantation accuracy in a single surgeon prospective cohort with a mean follow-up of two years. Methods: The study involved 522 patients with elective primary or complex primary total hip arthroplasty (THA) performed by a senior surgeon using the STAR approach between 2019 and 2023. 63.6% of the patients were female. The mean patients’ age was 65.6 years. 19.5% of the procedures were primary complex THAs. The mean follow-up and length of stay were 2.13 years and 1.50 days. The ratio of uncemented to hybrid and standard to dual mobility liner THAs were 3:2 and 4:1. Fifty-eight patients received blood transfusions. All patients followed the same postoperative protocol. Two physicians not involved in surgery collected clinical and radiological data. Efficacy was defined as measuring the cup inclination and anteversion, stem alignment, and leg length discrepancy (LLD) using the one-month postoperative standardised supine anteroposterior pelvic X-rays. The postoperative complication rate, including dislocation and infection, defined safety. Results: The mean cup inclination and anteversion were 42.80 (±4.9) and 19.90 (±8.9), respectively. 97.5% of the stems were placed in neutral and 2.5% in varus position. The mean LLD was 3.3 ± 6.3 mm. A single deep infection was managed with two-stage revision with no recurrence, and an early traumatic dislocation in an 80-year-old woman was managed successfully with closed reduction and hip spica. Three superficial wound infections were treated with oral antibiotics. Discussion: The STAR approach is safe and has demonstrated excellent early-to-mid-term efficacy profile outcomes. The unobstructed acetabular and femoral intraoperative view facilitated optimal implant positioning and contributed to excellent dislocation outcomes in combination with piriformis preservation.
Creating Edinburgh: diffracting interdisciplinary learning and teaching in the contemporary city
Authors: Cullen Clare , Jay David , Overend David , Winter M. 
Published: September 2024

AbstractThis article follows an experimental interdisciplinary undergraduate course in the busy, unpredictable space of the contemporary city. It locates practice-based research of interdisciplinary higher education in a dynamic learning environment, which is comprised of unpredictable connections between disciplinary perspectives. Following Karen Barad, the aim is to diffract interdisciplinary higher education in order to recognise and work with a multiplicity of meanings and experiences. This article explores an alternative to the dominant model of challenge-based learning in the interdisciplinary classroom. Creating Edinburgh: The Interdisciplinary City is an undergraduate elective offered by Edinburgh Futures Institute at the University of Edinburgh. It provides students with opportunities to explore the city of Edinburgh in small groups of students from a wide range of degree programmes. Groups are invited to engage with a selection of themed fieldwork topics throughout the 11 weeks of the course, visiting specific sites and responding to a series of tasks and questions. These include themes such as Sustainability, Decolonisation and Wildness, which are presented as interdisciplinary field topics to explore rather than problems to solve. This article develops a research methodology that sets out to travel with students as they navigate their way through the city during their weekly field trips. Combining first-hand autoethnographic accounts with walking interviews, it offers an insight into interdisciplinary learning and teaching in the expanded field of the contemporary city. Conceiving urban space as an assemblage of digital and non-digital objects, events and activities, members of the research team accompany students during their fieldwork, equipped with audio recorders, cameras and notebooks. The documents of these research journeys are then diffracted within a new materialist framework. The article concludes with questions and prompts for working with the agency and the affordances of a field-based education practice.
An upconversion device based on high-performance dual-layer white organic electroluminescent devices
Authors: Wang Weigao , Li Yiyang , Wan Yili , Duan Yu , An Hua , Peng Zhengchun 
Published: September 2024

Large-area imaging techniques in the short-wave infrared spectral region remain a pressing need. Organic light-emitting diodes and infrared photodetectors can be combined to form a near-infrared (NIR) to visible upconversion device, which has great potential to replace traditional infrared imaging systems. The integration of a white organic light-emitting diode (WOLED) with infrared photodetectors has become essential to realize full-color displays for its simple preparation process and high compatibility. This work has designed and optimized a WOLED to achieve stable emission with high brightness (19 470 cd m−2) and high external quantum efficiency (EQE = 18.08%) at a wide voltage range, thereby reducing chromaticity drift caused by voltage fluctuations. Moreover, photon-generated holes in the NIR-sensitive photodetector are able to inject into the WOLED for visible light emission. Consequently, we have obtained a high-performance upconversion device with a luminance on-off ratio exceeding 5 × 103 at 850 nm NIR and a high color stability over a wide range of operating voltage. Our efforts have accomplished a high-performance upconversion device from NIR to white visible light, laying the groundwork for a preliminary exploration of full-color displays.
The road ahead for Construction Grammar
Authors: Hilpert Martin 
Published: September 2024

Abstract
What does the future hold for Construction Grammar? What are the most promising future avenues for research on
constructions? This paper addresses the development of Construction Grammar as a theory of language through the perspective of six
recent PhD dissertations that explore constructional meaning, the architecture of the constructional network, and the role of
language change in a constructional theory of language. The goal of this paper is to establish connections between these ideas,
and to spell out how different questions concerning Frame Semantics, distributional semantic methods, priming, nodes and
connections, individual differences, and constructional change all contribute to a picture that is bigger than the sum of its
parts.
Using a rubric as a mediational tool to assess pre-service immersion teacher development
Authors: Tedick Diane J. , Mathieu Corinne S. 
Published: September 2024

Abstract
Dual language and immersion (DLI) teaching requires knowledge and pedagogical skills focused on language and
content integration (e.g., Cammarata & Tedick, 2012; Lyster, 2007; Tedick & Cammarata, 2023). Recent
scholarship has begun to articulate how best to prepare DLI teachers with such knowledge and skills (e.g., Cammarata & Haley, 2017; Tedick et al., 2024; Tedick & Zilmer, 2018). This study adds to this work by exploring how a DLI-specific
teacher assessment rubric mediates the learning process. Researchers created a DLI-specific rubric to aid pre-service teacher
candidates (TCs) in developing skills related to content and language integration. The case study explores one TC and one
supervisor’s experiences with the rubric. Data sources include audio “diaries” and video-recordings of post-observation
conferences between the two participants. Qualitative inductive analysis led to sociocultural concepts (Vygotsky, 1978) as explanatory tools for understanding the role of the rubric in the TC’s learning and
supervisor’s mentoring.
Challenges in the compilation, annotation, and analysis of learner corpus
data
Authors: Callies Marcus 
Published: September 2024

Abstract
This chapter highlights and discusses the special
characteristics of learner corpus data and the challenges they may present
for corpus compilation, annotation, and analysis. Because learner corpus and
SLA researchers use their data to study L2 production and development, it is
of utmost importance that the data are valid, that is, they represent
“authentic” L2 production, which means that the data must stem from the
studied learners’ own language production. I discuss challenges
in three areas: (1) multilingual practices and metalinguistic language use,
(2) lexical and constructional bias, often brought about by the wording of
task instructions or writing prompts that learners are asked to respond to,
and (3) learner corpus annotation in view of the “discourse of deficit” in
SLA. For each of these challenges solutions as to how they can be met are
offered.
Early newspapers as data for corpus linguistics (and Digital
Humanities)
Authors: Hiltunen Turo 
Published: September 2024

Abstract
The availability of large digital archives has great
potential for corpus linguistic research, but their use is not without
problems. These problems can often be traced to fundamentally different
ideas of what might constitute “good data” in Digital Humanities and in
corpus linguistics, leading to different expectations regarding how the data
is made available to researchers. This chapter discusses the specific
challenges involved in using the British Library Newspapers
database for corpus linguistics and considers potential solutions for them.
It is argued that, to take full advantage of the database, it is necessary
to adopt a flexible approach enabling a critical reflection on the digital
materials, how they have been collected, processed, and made available.
Open Corpus Linguistics – or How to overcome common problems in dealing
with corpus data by adopting open research practices
Authors: Hartmann Stefan 
Published: September 2024

Abstract
In recent years, many researchers have called attention
to the fact that research results very often cannot be replicated – a
phenomenon that has been called replication crisis. The
replication crisis in linguistics is highly relevant to corpus-based
research: Many corpus studies are not directly replicable as the data on
which they are based are not readily available. Especially in English
linguistics, the full versions of many widely used corpora are still behind
paywalls, which means that they are not accessible to parts of the global
research community, and even when parts of the data are freely accessible,
this presents problems for state-of-the-art methods of data analysis. In
this paper, I discuss the challenges that have led to this situation and
address some possible solutions. In particular, I argue for using smaller
but openly available corpora whenever possible and for adopting open
research practices as far as possible even when using commercial
corpora.