bluuebunny/crossref_metadata_2025_split huggingface dataset:
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure
Authors: Bansal Shyam S. , Ismahil Mohamed Ameen , Goel Mehak , Patel Bindiya , Hamid Tariq , Rokosh Gregg , Prabhu Sumanth D. 
Published: February 2017

Background—
Inappropriately sustained inflammation is a hallmark of chronic ischemic heart failure (HF); however, the pathophysiological role of T lymphocytes is unclear.

Methods and Results—

Permanent coronary ligation was performed in adult C57BL/6 mice. When compared with sham-operated mice, mice with HF (8 weeks after ligation) exhibited the following features: (1) significant (
P
<0.05) expansion of circulating CD3
+
CD8
+
cytotoxic and CD3
+
CD4
+
helper (Th) T lymphocytes, together with increased Th1, Th2, Th17, and regulatory T-cell (Treg) CD4
+
subsets; (2) significant expansion of CD8
+
and CD4
+
T cells in failing myocardium, with increased Th1, Th2, Th17, and Treg CD4
+
subsets, marked reduction of the Th1/Th2 ratio, augmentation of the Th17/Treg ratio, and upregulation of Th2 cytokines; and (3) significantly increased Th1, Th2, Th17 cells, and Tregs, in the spleen and mediastinal lymph nodes, with expansion of splenic antigen-experienced effector and memory CD4
+
T cells. Antibody-mediated CD4
+
T-cell depletion in HF mice (starting 4 weeks after ligation) reduced cardiac infiltration of CD4
+
T cells and prevented progressive left ventricular dilatation and hypertrophy, whereas adoptive transfer of splenic CD4
+
T cells (and, to a lesser extent, cardiac CD3
+
T cells) from donor mice with HF induced long-term left ventricular dysfunction, fibrosis, and hypertrophy in naive recipient mice.

Conclusions—

CD4
+
T lymphocytes are globally expanded and activated in chronic ischemic HF, with Th2 (versus Th1) and Th17 (versus Treg) predominance in failing hearts, and with expansion of memory T cells in the spleen. Cardiac and splenic T cells in HF are primed to induce cardiac injury and remodeling, and retain this memory on adoptive transfer.
Impact of Humanitarian Experiences on Otolaryngology Trainees: A Follow‐up Study of Travel Grant Recipients
Authors: Jafari Aria , Tringale Kathryn R. , Campbell Bruce H. , Husseman Jacob W. , Cordes Susan R. 
Published: February 2017

In this study, we seek (1) to determine the impact of humanitarian experiences on otolaryngology trainee recipients of the American Academy of Otolaryngology—Head and Neck Surgery Foundation humanitarian travel grant (2001‐2015); (2) to better understand trainee and trip characteristics, as well as motivations and attitudes toward future volunteerism; and (3) and to identify potential barriers to participation. An anonymous 30‐question survey was distributed to 207 individuals, and 52 (25.1%) responded. Respondents viewed the trip as very worthwhile (score = 98 of 100), expressed improved cultural understanding (75.0%), and continued participation in humanitarian activities (75.0%). Competency‐based evaluation results suggest a positive impact on systems‐based practice and professionalism. Respondents commented on the trip’s positive value and shared concerns regarding expense. Despite potential barriers, Foundation‐supported humanitarian trips during training are perceived as worthwhile; they may enhance cultural understanding and interest in future humanitarian efforts; and they may positively affect competency‐based metrics. Based on the potential benefits, continued support and formalization of these experiences should be considered.
Is it acceptable to video-record palliative care consultations for research and training purposes? A qualitative interview study exploring the views of hospice patients, carers and clinical staff
Authors: Pino Marco , Parry Ruth , Feathers Luke , Faull Christina 
Published: February 2017

Background: Research using video recordings can advance understanding of healthcare communication and improve care, but making and using video recordings carries risks. Aim: To explore views of hospice patients, carers and clinical staff about whether videoing patient–doctor consultations is acceptable for research and training purposes. Design: We used semi-structured group and individual interviews to gather hospice patients, carers and clinical staff views. We used Braun and Clark’s thematic analysis. Setting/participants: Interviews were conducted at one English hospice to inform the development of a larger video-based study. We invited patients with capacity to consent and whom the care team judged were neither acutely unwell nor severely distressed (11), carers of current or past patients (5), palliative medicine doctors (7), senior nurses (4) and communication skills educators (5). Results: Participants viewed video-based research on communication as valuable because of its potential to improve communication, care and staff training. Video-based research raised concerns including its potential to affect the nature and content of the consultation and threats to confidentiality; however, these were not seen as sufficient grounds for rejecting video-based research. Video-based research was seen as acceptable and useful providing that measures are taken to reduce possible risks across the recruitment, recording and dissemination phases of the research process. Conclusion: Video-based research is an acceptable and worthwhile way of investigating communication in palliative medicine. Situated judgements should be made about when it is appropriate to involve individual patients and carers in video-based research on the basis of their level of vulnerability and ability to freely consent.
Effect of Housing First on Suicidal Behaviour
Authors: Aquin Joshua P. , Roos Leslie E. , Distasio Jino , Katz Laurence Y. , Bourque Jimmy , Bolton James M. , Bolton Shay-Lee , Wong Jacquelyne Y. , Chateau Dan , Somers Julian M. , Enns Murray W. , Hwang Stephen W. , Frankish James C. , Sareen Jitender 
Published: February 2017

Objective: This study attempted to determine if Housing First (HF) decreased suicidal ideation and attempts compared to treatment as usual (TAU) amongst homeless persons with mental disorders, a population with a demonstrably high risk of suicidal behaviour. Method: The At Home/Chez Soi project is an unblinded, randomised control trial conducted across 5 Canadian cities (Vancouver, Winnipeg, Toronto, Montreal, Moncton) from 2009 to 2013. Homeless adults with a diagnosed major mental health disorder were recruited through community agencies and randomised to HF ( n = 1265) and TAU ( n = 990). HF participants were provided with private housing units and received case management support services. TAU participants retained access to existing community supports. Past-month suicidal ideation was measured at baseline and 6, 12, 18, and 21/24 months. A history of suicide attempts was measured at baseline and the 21/24-month follow-up. Results: Compared to baseline, there was an overall trend of decreased past-month suicidal ideation (estimate = –.57, SE = .05, P < 0.001), with no effect of treatment group (i.e., HF vs. TAU; estimate = –.04, SE = .06, P = 0.51). Furthermore, there was no effect of treatment status (estimate = –.10, SE = .16, P = 0.52) on prevalence of suicide attempts (HF = 11.9%, TAU = 10.5%) during the 2-year follow-up period. Conclusion: This study failed to find evidence that HF is superior to TAU in reducing suicidal ideation and attempts. We suggest that HF interventions consider supplemental psychological treatments that have proven efficacy in reducing suicidal behaviour. It remains to be determined what kind of suicide prevention interventions (if any) are specifically effective in further reducing suicidal risk in a housing-first intervention.
HRD Curriculum Meets Global Human Capital Challenge
Authors: Gaudet Cyndi H. , Brown H. Quincy , Lunsford Dale L. 
Published: February 2017

The Problem Human resource development (HRD) academic programs have grown and evolved over the last 25 plus years in a dynamic, global economy; yet, many HRD academic programs still grapple to define their role and purpose. Without the ability to clearly articulate the potential contributions undergraduate and graduate HRD programs offer the HRD profession, our universities, and global economy, we weaken our capacity to advance the field of HRD. Each year since 1999, The Conference Board, a global research association, has asked CEOs, presidents, and chair people across the globe to identify their most critical challenges. In the CEO Challenge 2015 and 2016 Reports, human capital was ranked as the number one global challenge. As the top challenge, CEOs view human capital in all its forms—from dynamic leadership to a skilled workforce cadre—as the primary fuel that will drive the engines of growth within their organizations. Undergraduate HRD programs are uniquely positioned to academically prepare entry-level professionals with the research-based knowledge, skills, and abilities required to develop the people needed for today’s organizations; yet universities struggle to find appropriate patterns and themes for their curriculum. The Solution This article provides a framework, an underlying structure, for undergraduate HRD academic programs mapped to strategies deployed globally by CEOs to meet their number one challenge of human capital—to build sustainable organizations and economies. Implications for developing undergraduate HRD curricula are included. The Stakeholders HRD scholars, practitioners, and higher education administrators interested in the academic preparation of entry-level HRD professionals.
Leveraging Three Lessons Learned From Teaching an HRD Undergraduate Diversity and Inclusion Course: An Autoethnography of One Professor’s Perceptions
Authors: Collins Joshua C. 
Published: February 2017

The ProblemAs a field, human resource development (HRD) is still in the early stages of figuring out the best ways to make the fundamental theories and practices of our discipline more accessible and useful to traditionally aged undergraduate students. Concurrently, the nature of jobs and careers are changing, and on a grand scale, bachelor’s degrees tend to no longer yield the same opportunities they used to. There is a growing expectation that new college graduates will be, among other things, savvy with/toward diversity and social justice, yet we know little about how HRD undergraduate programs function to prepare students to meet this demand.The SolutionThe purpose of this autoethnographic exploration was to detail and reflect upon one professor’s perceptions of the experience of teaching a diversity and inclusion course to HRD undergraduates at a predominantly White institution (PWI). Findings revealed three lessons learned: (a) valuing student expertise; (b) recognizing and counteracting implicit bias, both in the self and students; and (c) challenging student assumptions.The StakeholdersAll of us would benefit from an enhanced understanding of how undergraduates can contribute to diversity and our understanding of inclusivity in the field of HRD. The stakeholders of this article are HRD faculty, undergraduate students, and department and program administrators, as well as anyone who works in an organization that hires or is considering hiring new graduates into HRD positions.
Cavernous sinus dural arteriovenous fistula treated by facial vein direct puncture: Case report and review of the literature
Authors: Matsumoto Atsushi , Okauchi Masanobu , Shindo Atsushi , Kawanishi Masahiko , Tamiya Takashi 
Published: February 2017

Introduction In case of cavernous sinus dural arteriovenous fistula (CSDAVF), transvenous embolization (TVE) of the cavernous sinus (CS) via the inferior petrosal sinus (IPS) is generally performed. However, various approach routes have been reported when the accessibility of the IPS is challenging. We herein report a case of CSDAVF treated by TVE with direct puncture of the facial vein. Case report A 70-year-old woman who suffered from tinnitus, chemosis, diplopia and bruit was referred to our hospital. Digital subtraction angiography (DSA) demonstrated CSDAVF. We initially attempted to perform TVE via the IPS route; however, we could not guide a catheter to the CS because of an anatomical difficulty. Then, we performed percutaneous direct puncture of the dilated facial vein, and successfully treated the patient. Conclusion When navigating microcatheter to the CS is difficult because of an anatomical difficulty of the IPS, direct puncture of the facial vein is a feasible route.
Intra-articular fracture of proximal phalanx of great toe accompanied by valgus deformity associated with sports activities
Authors: Kim Sungsoo , Lee Myoungjin , Seok Sangyun 
Published: February 2017

Background: We analyzed clinical and radiologic examination of intra-articular fracture of the proximal phalanx of great toe accompanied by valgus deformity associated with sports activities. Therefore, we assessed valgus deformity of great toe at fracture side and contralateral side by simple radiograph in order to confirm the causal relation of fracture and deformity. Methods: A retrospective study was conducted on 23 cases, between January 2000 and August 2014, which showed an intra-articular fracture of proximal phalanx which was diagnosed after visiting our hospital for valgus deformity of great toe as a chief complaint. All patients were involved in sports activities for over 2 years. The site of fracture was the lateral side of the proximal phalanx head in 16 cases and the medial side of the proximal phalanx base in 7 cases. In order to assess the valgus deformity of great toe, hallux valgus angle (HVA) and hallux valgus interphalangeal angle (HVIPA) were measured on the weight-bearing foot radiograph. Results: The average HVA of the fracture group on the lateral side of the proximal phalanx head was 10.5° and HVIPA was 17.8°, while the average HVA of the fracture group on the medial side of the proximal phalanx base was 18.1° and HVIPA was 10.7°. Among the 16 cases with a fracture on the lateral side of the head, 13 cases showed hallux valgus interphalangeus (81.3%), while all 7 cases of fracture on the medial side of the base showed hallux valgus (100%). Conclusion: Hallux valgus was mostly found on the fracture of the medial side of the proximal phalanx base, while hallux valgus interphalangeus was mostly found on the fracture of the lateral side of the proximal phalanx head.
Type I interferon-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors
Authors: Govender Umeshree , Corre Béatrice , Bourdache Yasmine , Pellegrini Sandra , Michel Frédérique 
Published: February 2017

Abstract
Type I IFN can exert pro- and anti-inflammatory activities in the immune system. Here, we have investigated the mechanism by which IFN-α enhances early expression of the anti-inflammatory cytokine IL-10 in human CD45RA+CD4+ T cells. With the use of transcriptomic and biochemical approaches, we found distinct and combined contributions of the IFN and the TCR signaling pathways to the induction of STAT1/2/3 and the basic leucine zipper activating transcription factor-like (BATF) family members. Moreover, IFN-induced STAT3 phosphorylation was prolonged by the TCR response, whereas IFN-induced STAT2 phosphorylation was of long duration. With the use of RNA interference (RNAi), we identified STAT3 as the major actor and STAT2 as a contributor of the IFN action on IL-10. Upon TCR/IFN costimulation, STAT3 directly bound at the IL-10 conserved noncoding sequence (CNS)- 9, an enhancer element known to recruit BATF in CD4 T cells. The cosilencing of the 3 BATFs resulted in an overall reduction of IL-10 expression, but the promoting activity of IFN-α was retained. These results support the notion that the IFN action is indexed on BATF function and provide evidence for a cooperation between BATFs and STAT3, the latter being activated via early IFN and delayed TCR effects.
Declining oral intake towards the end of life: how to talk about it? A qualitative study
Authors: Clark Jean , Raijmakers Natasja J H , Allan Simon , Zuylen Lia van , Heide Agnes van der 
Published: February 2017

Background: Decreasing oral intake is common towards the end of life and a potential source of distress and concern for patients, relatives, whānau and clinicians. This paper provides insight to inform practice regarding clinicians' perceptions, practices, responses and communication with patients and their companions regarding declining oral intake towards the end of life. Methods: In this qualitative study ten specialist palliative care staff participated in semi-structured interviews. Qualitative thematic analysis was used to analyse the data. Findings: Three themes were identified: declining oral intake was a natural part of the dying process; responding empathetically; and clinicians described specific aims and ways regarding communication. Conclusion: Insight into clinicians' endeavours to manage declining oral intake and support the wellbeing of patients, families, and whānau can inform practice. However the perspectives of family, whānau and health professionals continue to show significant variation regarding the communication given and received around declining oral intake towards the end of life.
Family caregiver recruitment via social media: challenges, opportunities and lessons
Authors: Hansen Dana , Sheehan Denice K , Stephenson Pam 
Published: February 2017

Background: Illness blogs are a way seriously ill people communicate publicly about their illness journey. As communication about serious illness increases on social media, it is important to evaluate how this affects the family caregiver. However, identifying and accessing family caregivers remains challenging, especially via social media. Purpose: The aim of this article is to report the opportunities, challenges and lessons learned from using social media to recruit family caregivers. Methods: Recruitment methods included posting study invitations on illness blogs, advertising through Facebook and placing study fliers in the community. Results: Using social media to recruit was inexpensive and provided a wide geographical reach. One important finding was discovering the importance of using language in the recruitment materials that family caregivers could identify with to help deem themselves as eligible to participate in the study.
Efficiency testing of artificial neural networks in predicting the properties of carbon nanomaterials as potential systems for nervous tissue stimulation and regeneration
Authors: Sasiada Martyna , Fraczek-Szczypta Aneta , Tadeusiewicz Ryszard 
Published: February 2017

Abstract
A new method of predicting the properties of carbon nanomaterials from carbon nanotubes and graphene oxide, using electrophoretic deposition (EPD) on a metal surface, was investigated. The main goal is to obtain the basis for nervous tissue stimulation and regeneration. Because of the many variations of the EPD method, costly and time-consuming experiments are necessary for optimization of the produced systems. To limit such costs and workload, we propose a neural network-based model that can predict the properties of selected carbon nanomaterial systems before they are produced. The choice of neural networks as predictive learning models is based on many studies in the literature that report neural models as good interpretations of real-life processes. The use of a neural network model can reduce experimentation with unpromising methods of systems processing and preparation. Instead, it allows a focus on experiments with these systems, which are promising according to the prediction given by the neural model. The performed tests showed that the proposed method of predictive learning of carbon nanomaterial properties is easy and effective. The experiments showed that the prediction results were consistent with those obtained in the real system.
Dynamic Stability of Post-Keynesian Pricing
Authors: Kemp-Benedict Eric 
Published: February 2017

AbstractConventional economic theory assumes a Walrasian pricing mechanism that is known to pose theoretical difficulties. Less well-known is that conventional price theory conflicts with empirical studies of price-setting in industrial firms. Post-Keynesian theory, which assumes mark-up pricing on normal costs and infrequent price changes, is consistent with observation, and we show in this paper that post-Keynesian pricing, unlike conventional pricing, features stable dynamics. We focus on the short run, because post-Keynesian theory posits complex and historically-contingent long-term price dynamics. Specifically, we show that under very general conditions, prices converge to a unique equilibrium price vector.
An approach for estimating measurement uncertainty in medical laboratories using data from long-term quality control and external quality assessment schemes
Authors: Padoan Andrea , Antonelli Giorgia , Aita Ada , Sciacovelli Laura , Plebani Mario 
Published: February 2017

AbstractBackground:The present study was prompted by the ISO 15189 requirements that medical laboratories should estimate measurement uncertainty (MU).Methods:The method used to estimate MU included the: a) identification of quantitative tests, b) classification of tests in relation to their clinical purpose, and c) identification of criteria to estimate the different MU components. Imprecision was estimated using long-term internal quality control (IQC) results of the year 2016, while external quality assessment schemes (EQAs) results obtained in the period 2015–2016 were used to estimate bias and bias uncertainty.Results:A total of 263 measurement procedures (MPs) were analyzed. On the basis of test purpose, in 51 MPs imprecision only was used to estimate MU; in the remaining MPs, the bias component was not estimable for 22 MPs because EQAs results did not provide reliable statistics. For a total of 28 MPs, two or more MU values were calculated on the basis of analyte concentration levels. Overall, results showed that uncertainty of bias is a minor factor contributing to MU, the bias component being the most relevant contributor to all the studied sample matrices.Conclusions:The model chosen for MU estimation allowed us to derive a standardized approach for bias calculation, with respect to the fitness-for-purpose of test results. Measurement uncertainty estimation could readily be implemented in medical laboratories as a useful tool in monitoring the analytical quality of test results since they are calculated using a combination of both the long-term imprecision IQC results and bias, on the basis of EQAs results.
Evaluation of two fully automated immunoassay based tests for the measurement of 1α,25-dihydroxyvitamin D in human serum and comparison with LC-MS/MS
Authors: Spanaus Katharina , von Eckardstein Arnold 
Published: February 2017

AbstractBackground:1α,25-Dihydroxyvitamin D [1,25(OH)Methods:In the presented study, we evaluated the performance of two immunoassays from DiaSorin and from Immunodiagnostic Systems (IDS) which combine fully automated extraction and measurement of 1,25(OH)Results:Total imprecision was 5.2% or less for the DiaSorin test but reached 20.1% for the IDS iSYS test. 1,25(OH)Conclusions:Due to its high sensitivity, low imprecision, broad measurement range, and good agreement with 1,25(OH)