bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: 1,3‐Dipolare Cycloaddition von Diazoalkanen an Isopropenyl‐phosphonate und einige physikalisch‐chemische Eigenschaften phosphororganischer Verbindungen der Cyclopropanreihe.
Authors: GAREEV R. D. , CHERNOVA A. V. , IZHMAEVA Z. A. , BERDNIKOV E. A. , SHAGIDULLIN R. R. , STRELKOVA E. N. , DOROZHKINA G. M. , PATSANOVSKII I. I. , PUDOVIK A. N. 
Published: May 2016

AbstractO,ODimethyl‐isopropenyl‐phosphonat (I) reagiert unter Cycloaddition mit den O,O‐Dialkyl‐a‐diazo‐ethyl‐phosphonaten (II) zu den Al‐Pyrazolinen (III).
ChemInform Abstract: INVERSION OF REGIOSPECIFICITY IN 1,3‐DIPOLAR CYCLOADDITION OF DIAZOALKANES TO β‐CARBOMETHOXYVINYLPHOSPHORYL COMPOUNDS
Authors: GAREEV R. D. , PUDOVIK A. N. 
Published: May 2016

AbstractO‐Methyl‐methyl‐ β‐carbomethoxy‐vinylphosphinat (I) reagiert mit Diazomethan (II) bevorzugt zu dem Diastereomerenpaar (III) neben dem Diastereomerenpaar (IV).
ChemInform Abstract: REACTION OF THIOPHENE WITH MENSCHUTKIN′S ACID CHLORIDES
Authors: KRASIL'NIKOVA E. A. , SHARAFIEVA E. S. , RAZUMOV A. I. 
Published: May 2016

AbstractAus Thiophen (I) und Alkyl‐dichlorphosphiten (II) entsteht ein Gemisch aus Alkyl‐dithienyl‐phosphiniten (III), Phosphinen (IV) und Phosphinoxiden (V).
ChemInform Abstract: REACTION OF UNSATURATED DIBROMOPHOSPHINES WITH ACETYLENIC ALCOHOLS
Authors: BELYAEVA T. N. , SENDYUREV M. V. , DOGADINA A. V. , IONIN B. I. , PETROV A. A. 
Published: May 2016

AbstractAlkenylphosphonigsäure‐dibromide (I) reagieren mit 2 Mol eines Acetylenalkohols (II) unter teilweiser Acetylen‐Allen‐Umlagerung zu den Mono‐alkinylest ern der Alkenyl‐(1 ,2‐ alkadienyl)‐phosphinsäuren (III).
ChemInform Abstract: GERMATRANES. IV. SYNTHESIS, PROTON NMR, AND MASS SPECTRA OF 1‐HYDROGERMATRANE E AND ITS C‐METHYL‐SUBSTITUTED HOMOLOGS
Authors: GAR T. K. , KHROMOVA N. YU. , TANDURA S. N. , BOCHKAREV V. N. , CHERNYSHEV A. E. , MIRONOV V. F. 
Published: May 2016

AbstractDer Komplex (I) reagiert mit den Aminoalkoholen (II) zu den 1‐Hydrogermatranen (III).
ChemInform Abstract: SYNTHESIS AND SPECTROSCOPIC STUDY OF A TRANSITION METAL‐SUBSTITUTED PHOSPHORANE: 2‐PENTACARBONYLMANGANESE‐2,2′‐SPIROBI(1,3,2‐BENZODIOXAPHOSPHOLE)
Authors: LATTMAN M. , ANAND B. N. , GARRETT D. R. , WHITENER M. A. 
Published: May 2016

AbstractDie Titelverbindung (II) entsteht durch die Umsetzung des Chloro‐Analogen (I) mit dem aus Decacarbonyldimangan durch Na‐amalgam‐Reduktion erzeugten Na‐pentacarbonylmanganat.
ChemInform Abstract: THE SYNTHESIS AND CHARACTERIZATION OF NI(P(OPH)3)2(SN3).2H2O, (SULFUR TRINITRIDE)BIS(TRIPHENYL PHOSPHITE)NICKEL(II) DIHYDRATE
Authors: BHATTACHARYYA A. A. , TURNER A. G. 
Published: May 2016

AbstractTetrakis‐[triphenylphosphit]‐Ni in Benzol reagiert mit überschüssigem S4N4 zu dem diamagnetischen, quadratisch‐planaren Ni(II)‐Titelkomplex mit N,N‐gebundenem SN3‐Dianion (Ausb. 53%).
ChemInform Abstract: REACTIONS OF DIAMINOSULFANES WITH COPPER(II) SALTS
Authors: GONZALEZ G. , DIAZ C. , COPAJA S. 
Published: May 2016

AbstractDie Reaktionen der Sulfane (I) mit [Cu(H2O)6](ClO4), in Acetonitril und mit CuCl2 ° 2 H2O in Ethanol liefern die Cu(I)‐Verbindungen (II) bzw. (IV) und S02.
ChemInform Abstract: STEREOCHEMICAL INVERSION IN THE SUBSTITUTION REACTIONS OF DICHLOROETHYLENEDIAMINE‐N,N′‐DI‐S‐α‐PROPIONATORHODATE(III) ION
Authors: SHERIDAN M. E. F. , JUN M.‐J. , LIU C. F. 
Published: May 2016

AbstractCD‐spektroskopische Untersuchungen bestätigen, daß die Substitutionsreaktion des A‐cis‐β‐Isomeren (III) des Titelkomplexes mit Aminosäure unter vollständiger Isomerisierung zu dem A‐cis‐oz‐Produkt (II) erfolgt, während diese Reaktion des A‐cis‐a‐Isomeren (I) unter Retention der Kon?gu‐ 135 ration verläuft.
ChemInform Abstract: TRANSITION METAL COMPLEXES WITH NITRONYLNITROXYL RADICAL LIGANDS
Authors: SCHWARZHANS K. E. , STUEFER A. 
Published: May 2016

AbstractDas nach bekannter Methode erhaltene Bis‐[hydroxylamino]‐2,3‐dimethylbutanhydrogensulfat reagiert mit den o‐, m‐ und p‐Pyridinaldehyden zu den stabilen freien Radikalen (I), die als Liganden zur Synthese von Komplexverbindungen eingesetzt werden.
ChemInform Abstract: REACTION OF AN α,β‐UNSATURATED NITRO COMPOUND WITH LITHIUM DIMETHYLCUPRATE. A NOVEL SYNTHESIS OF A 3α,5α‐CYCLOSTEROID
Authors: STIVER S. , YATES P. 
Published: May 2016

AbstractDas Acetoxy‐nitro‐cholesten (I) reagiert mit überschüssigem Lithiumdimethylcuprat zum (E)‐Oxim (II) und zu weiteren Verbindungen, z.B. (III), von denen (II) in einer Beckmann‐Umlagerung das Cycloazahomocholestanon (IV) ergibt.
ChemInform Abstract: SYNTHESIS OF AMYLOSTATIN (XG), α‐GLUCOSIDASE INHIBITOR WITH BASIC PSEUDOTRISACCHARIDE STRUCTURE
Authors: SAKAIRI N. , KUZUHARA H. 
Published: May 2016

AbstractDie bezüglich ihrer Herstellung ausführlich beschriebenen Bausteine (I) und (II) werden zur Synthese von Amylostatin (XG) (IIIb) herangezogen.
ChemInform Abstract: SYNTHESIS OF PEPTIDE ALKALOIDS. PART 8. TOTAL SYNTHESIS OF MUCRONIN B
Authors: SCHMIDT U. , SCHANBACHER U. 
Published: May 2016

AbstractDie Synthese des Titel‐peptidalkaloids (VI) erfolgt ausgehend von der Dehydroaminosäure (I) sukzessiv über die angegebenen Stufen.
ChemInform Abstract: MEZLOCILLIN: A PENICILLIN FROM THE ACYLUREIDO SERIES. SYNTHESIS AND CHEMICAL PROPERTIES
Authors: KOENIG H.‐B. + , METZGER K. G. , OFFE H.‐A. , SCHROECK W. + 
Published: May 2016

AbstractDurch Acylierung von Ampicillin (II) mit dem Chlorcarbonylimidazolidinon (Ic) erhält man die Mezlocillinsäure (IIIa), aus der das Mezlocillin‐natrium‐ Salz (IIIb) hergestellt wird.
Exploration of a Library of 3,4‐(Methylenedioxy)aniline‐Derived Semicarbazones as Dual Inhibitors of Monoamine Oxidase and Acetylcholinesterase: Design, Synthesis, and Evaluation
Authors: Tripathi Rati K. P. , Rai Gopal K. , Ayyannan Senthil R. 
Published: May 2016

AbstractA library of 3,4‐(methylenedioxy)aniline‐derived semicarbazones was designed, synthesized, and evaluated as monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibitors for the treatment of neurodegenerative diseases. Most of the new compounds selectively inhibited MAO‐B and AChE, with IC50 values in the micro‐ or nanomolar ranges. Compound 16, 1‐(2,6‐dichlorobenzylidene)‐4‐(benzo[1,3]dioxol‐5‐yl)semicarbazide presented a balanced multifunctional profile of MAO‐A (IC50=4.52±0.032 μm), MAO‐B (IC50=0.059±0.002 μm), and AChE (IC50=0.0087±0.0002 μm) inhibition without neurotoxicity. Kinetic studies revealed that compound 16 exhibits competitive and reversible inhibition against MAO‐A and MAO‐B, and mixed‐type inhibition against AChE. Molecular docking studies further revealed insight into the possible interactions within the enzyme–inhibitor complexes. The most active compounds were found to interact with the enzymes through hydrogen bonding and hydrophobic interactions. Additionally, in silico molecular properties and ADME properties of the synthesized compounds were calculated to explore their drug‐like characteristics.
Cyclic Ketoximes as Estrogen Receptor β Selective Agonists
Authors: Granchi Carlotta , Lapillo Margherita , Spena Concetta Russo , Rizzolio Flavio , Tuccinardi Tiziano , Martin Teresa A. , Carlson Kathryn E. , Katzenellenbogen John A. , Minutolo Filippo 
Published: May 2016

AbstractThe development of estrogen receptor β (ERβ)‐selective agonists represents a therapeutic strategy against several kinds of cancers, but the high homology between the two receptor subtypes, ERα and ERβ, makes the achievement of this goal very challenging. In the past, we developed salicylaldoxime‐ and salicylketoxime‐based molecules that proved to bind well to ERβ. In this paper, further structural evolution of the salicylketoximes is presented: two of the newly synthesized five‐membered cyclic ketoximes bind with nanomolar affinities to ERβ, and they show selectivity for this subtype over ERα. Their agonist character was confirmed by cell‐free coactivator recruitment assays, in which we demonstrated the ability of these compounds to form an active complex with ERβ capable of recruiting coactivator proteins; this indicated their efficacy as agonists. Finally, their potency and selectivity for ERβ binding were rationalized by molecular‐modeling studies.
A randomized trial of videoconference‐delivered cognitive behavioral therapy for survivors of breast cancer with self‐reported cognitive dysfunction
Authors: Ferguson Robert J. , Sigmon Sandra T. , Pritchard Andrew J. , LaBrie Sharon L. , Goetze Rachel E. , Fink Christine M. , Garrett A. Merrill 
Published: May 2016

BACKGROUNDLong‐term chemotherapy‐related cognitive dysfunction (CRCD) affects a large number of cancer survivors. To the authors' knowledge, to date there is no established treatment for this survivorship problem. The authors herein report results of a small randomized controlled trial of a cognitive behavioral therapy (CBT), Memory and Attention Adaptation Training (MAAT), compared with an attention control condition. Both treatments were delivered over a videoconference device.METHODSA total of 47 survivors of female breast cancer who reported CRCD were randomized to MAAT or supportive therapy and were assessed at baseline, after treatment, and at 2 months of follow‐up. Participants completed self‐report measures of cognitive symptoms and quality of life and a brief telephone‐based neuropsychological assessment.RESULTSMAAT participants made gains in perceived (self‐reported) cognitive impairments (P = .02), and neuropsychological processing speed (P = .03) compared with supportive therapy controls. A large MAAT effect size was observed at the 2‐month follow‐up with regard to anxiety concerning cognitive problems (Cohen's d for standard differences in effect sizes, 0.90) with medium effects noted in general function, fatigue, and anxiety. Survivors rated MAAT and videoconference delivery with high satisfaction.CONCLUSIONSMAAT may be an efficacious psychological treatment of CRCD that can be delivered through videoconference technology. This research is important because it helps to identify a treatment option for survivors that also may improve access to survivorship services. Cancer 2016;122:1782‐91. © 2016 American Cancer Society.
Access control mechanism using flexible multi‐layer structure for mesh‐based P2P live streaming systems
Authors: Sue Chuan‐Ching , Chuang Kai‐Chun , Hsu Chi‐Yu 
Published: May 2016

SummaryWhen thousands of new peers seek to join the peer‐to‐peer (P2P) system within a very short time (i.e., the so‐called flash crowd event), most of the peers suffer a long startup delay as a result of peer over‐competition. Accordingly, recent studies have proposed a slot‐based user access control (UAC) mechanism, which periodically admits a certain number of new peers to the system, and a user batch join (UBJ) mechanism, which preconstructs the new peers into a fixed‐size tree structure before peer join process. However, in the UAC mechanism, it is difficult to determine the optimal time slot length; while in the UBJ mechanism, it is difficult to determine the optimal tree size. Accordingly, the present study proposes a structured access control (SAC) mechanism, in which the new‐arriving peers are preconstructed to a flexible multilayer structure to overcome the limitation of a fixed‐size tree structure, and the number of peers in each layer of the structure is determined based on a consideration of the remaining upload bandwidth of the P2P system. Based on the assumption of a heterogeneous upload bandwidth capability of the peers, an analytical model is derived to describe the growth behavior of a P2P system with access control. It is shown that the simulation results for the growth rate of a P2P system based on the SAC mechanism are in good agreement with those obtained from the analytical model. In addition, the simulation results show that the SAC mechanism outperforms the UAC and UBJ mechanisms in terms of a more rapid system growth and a shorter average startup delay. Copyright © 2016 John Wiley & Sons, Ltd.
Queue‐based multiple path load balancing routing protocol for MANETs
Authors: Naseem Mohd , Kumar Chiranjeev 
Published: May 2016

SummaryCongestion in the network is the main cause for packet drop and increased end‐to‐end transmission delay of packet between source and destination nodes. Congestion occurs because of the simultaneous contention for network resources. It is very important to efficiently utilize the available resources so that a load can be distributed efficiently throughout the network. Otherwise, the resources of heavily loaded nodes may be depleted very soon, which ultimately affects network performances. In this paper, we have proposed a new routing protocol named queue‐based multiple path load balancing routing protocol. This protocol discovers several node‐disjoint paths from source to destination nodes. It also finds minimum queue length with respect to individual paths, sorts the node‐disjoint paths based on queue length, and distributes the packets through these paths based on the minimum queue length. Simulation results show that the proposed routing protocol distributes the load efficiently and achieves better network performances in terms of packet delivery ratio, end‐to‐end delay, and routing overhead. Copyright © 2016 John Wiley & Sons, Ltd.
Mediterranean cold‐water corals – an important regional carbonate factory?
Authors: Titschack Jürgen , Fink Hiske G. , Baum Daniel , Wienberg Claudia , Hebbeln Dierk , Freiwald André 
Published: May 2016

AbstractThis study presents aggradation rates supplemented for the first time by carbonate accumulation rates from Mediterranean cold‐water coral sites considering three different regional and geomorphological settings: (i) a cold‐water coral ridge (eastern Melilla coral province, Alboran Sea), (ii) a cold‐water coral rubble talus deposit at the base of a submarine cliff (Urania Bank, Strait of Sicily) and (iii) a cold‐water coral deposit rooted on a predefined topographic high overgrown by cold‐water corals (Santa Maria di Leuca coral province, Ionian Sea). The mean aggradation rates of the respective cold‐water coral deposits vary between 10 and 530 cm kyr−1 and the mean carbonate accumulation rates range between 8 and 396 g cm−2 kyr−1 with a maximum of 503 g cm−2 kyr−1 reached in the eastern Melilla coral province. Compared to other deep‐water depositional environments the Mediterranean cold‐water coral sites reveal significantly higher carbonate accumulation rates that were even in the range of the highest productive shallow‐water Mediterranean carbonate factories (e.g. Cladocora caespitosa coral reefs). Focusing exclusively on cold‐water coral occurrences, the carbonate accumulation rates of the Mediterranean cold‐water coral sites are in the lower range of those obtained for the prolific Norwegian coral occurrences, but exhibit much higher rates than the cold‐water coral mounds off Ireland. This study clearly indicates that cold‐water corals have the potential to act as important carbonate factories and regional carbonate sinks within the Mediterranean Sea. Moreover, the data highlight the potential of cold‐water corals to store carbonate with rates in the range of tropical shallow‐water reefs. In order to evaluate the contribution of the cold‐water coral carbonate factory to the regional or global carbonate/carbon cycle, an improved understanding of the temporal and spatial variability in aggradation and carbonate accumulation rates and areal estimates of the respective regions is needed.
Novel pathomechanisms of cardiomyocyte dysfunction in a model of heart failure with preserved ejection fraction
Authors: Primessnig Uwe , Schönleitner Patrick , Höll Alexander , Pfeiffer Susanne , Bracic Taja , Rau Thomas , Kapl Martin , Stojakovic Tatjana , Glasnov Toma , Leineweber Kirsten , Wakula Paulina , Antoons Gudrun , Pieske Burkert , Heinzel Frank R. 
Published: May 2016

AbstractAimsHeart failure with preserved ejection fraction (HFpEF) is increasingly common, but the underlying cellular mechanisms are not well understood. We investigated cardiomyocyte function and the role of SEA0400, an Na+/Ca2+ exchanger (NCX) inhibitor in a rat model of chronic kidney disease (CKD) with HFpEF.Methods and resultsMale Wistar rats were subjected to subtotal nephrectomy (NXT) or sham operation (Sham). After 8 and 24 weeks, in vivo (haemodynamics, echocardiography) and in vitro function (LV cardiomyocyte cell shortening (CS), and Ca2+ transients (CaT)) were determined without and with SEA0400. In a subgroup of rats, SEA0400 or vehicle was given p.o. (1 mg/kg b.w.) between week 8 and 24. NXT resulted in stable compensated CKD and HFpEF [hypertrophied left ventricle, prolonged LV isovolumetric relaxation constant TAU (IVRc TAU), elevated end diastolic pressure (EDP), increased lung weight (pulmonary congestion), and preserved LV systolic function (EF, dP/dt)]. In NXT cardiomyocytes, the amplitude of CS and CaT were unchanged but relaxation and CaT decay were progressively prolonged at 8 and 24 weeks vs. Sham, individually correlating with diastolic dysfunction in vivo. NCX forward mode activity (caffeine response) was progressively reduced, while NCX protein expression was up‐regulated, suggesting increased NCX reverse mode activity in NXT. SEA0400 acutely improved relaxation in NXT in vivo and in cardiomyocytes and improved cardiac remodelling and diastolic function when given chronically.ConclusionsThis model of renal HFpEF is associated with slowed relaxation of LV cardiomyocytes. Treatment with SEA0400 improved cardiomyocyte function, remodelling, and HFpEF.
Exercise tolerance can explain the obesity paradox in patients with systolic heart failure: data from the MECKI Score Research Group
Authors: Piepoli Massimo F. , Corrà Ugo , Veglia Fabrizio , Bonomi Alice , Salvioni Elisabetta , Cattadori Gaia , Metra Marco , Lombardi Carlo , Sinagra Gianfranco , Limongelli Giuseppe , Raimondo Rosa , Re Federica , Magrì Damiano , Belardinelli Romualdo , Parati Gianfranco , Minà Chiara , Scardovi Angela B. , Guazzi Marco , Cicoira Mariantonietta , Scrutinio Domenico , Di Lenarda Andrea , Bussotti Maurizio , Frigerio Maria , Correale Michele , Villani Giovanni Quinto , Paolillo Stefania , Passino Claudio , Agostoni Piergiuseppe ,   on behalf of the MECKI Score Research Group
Published: May 2016

AbstractAimsObesity has been found to be protective in heart failure (HF), a finding leading to the concept of an obesity paradox. We hypothesized that a preserved cardiorespiratory fitness in obese HF patients may affect the relationship between survival and body mass index (BMI) and explain the obesity paradox in HF.Methods and resultsA total of 4623 systolic HF patients (LVEF 31.5 ± 9.5%, BMI 26.2 ± 3.6 kg/m2) were recruited and prospectively followed in 24 Italian HF centres belonging to the MECKI Score Research Group. Besides full clinical examination, patients underwent maximal cardiopulmonary exercise test at study enrolment. Median follow‐up was 1113 (553–1803) days. The study population was divided according to BMI (<25, 25–30, >30 to ≤35 kg/m2) and predicted peak oxygen consumption (peak VO2, <50%, 50–80%, >80%). Study endpoints were all‐cause and cardiovascular deaths including urgent cardiac transplant. All‐cause and cardiovascular deaths occurred in 951 (28.6%, 57.4 per person‐years) and 802 cases (17.4%, 48.4 per 1000 person‐years), respectively. In the high BMI groups, several prognostic parameters presented better values [LVEF, peak VO2, ventilation/carbon dioxide slope, renal function, and haemoglobin (P < 0.01)] compared with the lower BMI groups. Both BMI and peak VO2 were significant positive predictors of longer survival: both higher BMI and peak VO2 groups showed lower mortality (P < 0.001). At multivariable analysis and using a matching procedure (age, gender, LVEF, and peak VO2), the protective role of BMI disappeared.ConclusionExercise tolerance affects the relationship between BMI and survival. Cardiorespiratory fitness mitigates the obesity paradox observed in HF patients.
An Efficient Synthetic Access to Substituted Thiazolyl‐pyrazolyl‐chromene‐2‐ones from Dehydroacetic Acid and Coumarin Derivatives by a Multicomponent Approach
Authors: Ben Mohamed Soumaya , Rachedi Yahia , Hamdi Maamar , Le Bideau Franck , Dejean Camille , Dumas Françoise 
Published: May 2016

AbstractTwo new series of pyran‐ or coumarin‐substituted thiazolyl‐pyrazole‐chromen‐2‐one derivatives 10a–10d and 11a–11d were efficiently synthesized under environmentally friendly reaction conditions through a convenient one‐pot multicomponent reaction of a heterocyclic bromoacetyl derivative 3 or 4 with thiosemicarbazide and a substituted 3‐(acetoacetyl)coumarin derivative 5a–5d in anhydrous ethanol. The reaction proceeds through Hantzsch thiazole and Knorr pyrazole syntheses in refluxing ethanol. The key features of this approach are its operational simplicity, the quick access to the desired products, and the good to excellent yields. The structures of the newly synthesized compounds were established by IR spectroscopy, 1H, 13C, and 2D NMR spectroscopy, and mass spectrometry.
Nanostructured Conducting Polymer/Copper Oxide as a Modifier for Fabrication of L‐DOPA and Uric Acid Electrochemical Sensor
Authors: Sheikh‐Mohseni Mohammad Ali , Pirsa Sajad 
Published: May 2016

AbstractA modified electrode was prepared by modification of the carbon paste electrode (CPE) with a nanostructured material. This nanostructure with electrocatalytic activity was synthesized by combination of poly pyrrole and copper oxide nanoparticles (PPy/CuO). The structure and morphology of PPy/CuO was studied. The fabricated modified electrode (CPE‐PPy/CuO) exhibited an excellent electrocatalytic activity toward levodopa (L‐DOPA) and uric acid (UA) oxidation because of high conductivity, low electron transfer resistance and catalytic effect. The CPE‐PPy/CuO had a lower overvoltage and enhanced electrical current with respect to the bare CPE for both L‐DOPA and UA. Also, the modified electrode showed a good resolution for the overlapped anodic peaks of L‐DOPA and UA. This electrode was used for the successful simultaneous determination of L‐DOPA and UA. The electrochemical sensor responded to L‐DOPA and UA in the concentration range of 0.050–1200 μM and 0.040–2000 μM, respectively. The detection limits were obtained by differential pulse voltammetry as 15 nM for L‐DOPA and 20 nM for UA. Finally, the proposed electrode was used for determination of L‐DOPA and UA in real samples using standard addition method.
Quantification of hydroperoxides by gas chromatography‐flame ionization detection and predicted response factors
Authors: Leocata Sabine , Frank Sandy , Wang Ying , Calandra Michael J. , Chaintreau Alain 
Published: May 2016

AbstractThe quantification of hydroperoxides is crucial in several areas, in particular in the fragrance domain, because they have been identified as skin sensitizers. The reference compounds necessary to calibrate the instruments have very limited availability, and require drastic storage conditions (‐78 °C) due to their instability. To overcome these limitations, we propose a GC‐FID approach involving their silylation, and the prediction of response factors. This procedure provides a good alternative to a full calibration down to a concentration level of 500 mg/kg, with an underestimation of about 20%. In the analysis of essential oils and fragrance concentrates, larger deviations are found; however, they are not inherent in the technique but rather in the chemistry of hydroperoxides that readily react with aldehydes to form peroxyhemiacetals, thereby decreasing the concentration of free hydroperoxides. These observations are in agreement with quantitative 1H NMR and HPLC‐Chemiluminescence analyses. Copyright © 2016 John Wiley & Sons, Ltd.