bluuebunny/crossref_metadata_2025_split huggingface dataset:
TCF7L2 gene polymorphisms rs12255372, rs7903146, rs10885406 and the association with type 2 diabetes in a population of Legian Village, Kuta, Bali.
Authors: Saraswati Made Ratna , Suastika Ketut , Malik Safarina G. , Sudoyo Herawati 
Published: September 2017

Background: Polymorphisms in the transcription factor 7 like-2 (TCF7L2) gene have been consistently reported to be associated with increased risk of type 2 diabetes mellitus in various populations, in particular, the rs7903146, rs12255372, and rs10885406 polymorphism. Objective: The aim of this study was to investigate whether these polymorphisms in the Balinese population of Legian village. Methods: A cross-sectional study enrolling 286 participants (178 male, 108 female), mean age was 46.0Â±10.0 (range 20â€“83) years. PCR-RFLP conducted genotyping for rs7903146, rs12255372, and rs10885406 polymorphism, fasting and two hours after meal blood glucose were measured. Studentâ€™s t-test and analysis of variance (ANOVA) and chi-square test were employed. Â Results: The frequencies of the CC and CT genotypes of the rs7903146 polymorphism were 93.4% and 6.6%. The GG and GT genotypes of the rs12255372 polymorphism were 94.8% and 5.2%, while in the rs10885406 they were 87.1%, 12.2%, and 0.7% for the AA, AG, and GG genotypes. The TT genotypes of the rs7903146 and rs12255372 not found. The prevalence of type 2 diabetes in this population were 9.0%. The frequency of the CT genotype of the rs7903146 was higher in diabetes compare to the non-diabetes group (7.6% vs. 6.5%, p=0.822), while GT genotype in rs12255372 was lower (3.8% vs. 5.3%, p=0.737). The AG genotype of the rs10885406 also lower in diabetes group (7.6% vs. 12.6%, p=0.679). In the CT genotypeÂ of rs7903146, the two hours after meal blood glucose were significantly higher (141.15 Â± 125.06 vs. 107.50 Â± 46.94, p=0.012). Interestingly, although not statistically significant, individuals with the GG genotype showed the lowest blood glucose. Conclusion: Rs7903146, rs12255372, and rs10885406 polymorphisms in the TCF7L2 genes did not show association with type 2 diabetes in the Balinese population of Legian Village. However, two hours after meal blood glucose level was found to be significantly higher in the CT genotype of the rs7903146.
Increased incidence of nausea and vomiting due to anxiety in palcitaxel and carboplatin chemotherapy in a 48 years old female patient with cervical cancer
Authors: Putra I. F. W. , Noviyani R. , Suwiyoga K. 
Published: September 2017

Nausea and vomiting was the frequently side effects in chemotherapy.Uncontrolled nausea and vomiting can cause weakened body condition, reduced appetite and drinking, dehydration, electrolyte disturbances, reduced nutritional status so the patient refused to undergo further chemotherapy. Anxiety is one of the factors that increase the risk of nausea and vomiting. We reported the case of the woman 48 years old, height 150 cm, weight 51 kg, occupation housewife, diagnosed non-keratinizing squamous cell carcinoma cervical cancerÂ stage-IIB and received paclitaxel carboplatin for three cycles of chemotherapy. She experienced anxiety, acute nausea vomiting on the third cycle of chemotherapy and delayed nausea and vomiting of the three cycles of chemotherapy.
THE ROLE OF GLOMERULOSCLEROSIS ANDTUBULAR ATROPHYAS DETERMINING FACTORFOR REDUCED KIDNEY FUNCTION IN KIDNEY STONE DISEASE
Authors: Oka A. A. Gde , Widiana I G. Raka 
Published: September 2017

Kidney fibrosis including glomerulosclerosis (GS) and tubulointerstitial fibrosis (TIF) or tubular atrophy (TA)may be a predictor of kidney dysfunction. Estimated glomerular filtration rate (eGFR) isa common laboratory examination to estimate the kidney function. The aim of this research is to determine relationship between histologic features namely glomerulosclerosis (GS) and tubular atrophy (TA),and estimated glomerular filtration rate (eGFR) in kidney stone disease.A cross-sectional study in a total of the 63 patients with kidney stone consistedofÂ 25 (39.7 %) males and Â 38 (60.3 %) females, aged (51 Â± 11 years), BUN 16 (8-62) mg/dl, serum creatinine 1.26 ( 0.47- 6.76 ) mg/dl and eGFR 61.4 Â± 32.1 ml/min. Histologic features showed GS index 6 (0-30) and TA index 892 Â± 333. There was significant correlation between eGFR and GS index dan TA index(r -0,577; p=0.001 and 0,514;p = 0,001, consecutively). Multivariate regresion equations were eLFG = 67,21 -1.63 (GS index) and eLFG = 67,21 + 0,01 (TA index).Estimated GFR may be used as a marker of glomerulosclerosis and tubular atrophy in obstructive nephropathy of kidney stone patients.
EXPRESSIONS OF STEM CELL FACTOR AND TYROSINASE POSITIVELY CORRELATE WITH EXPRESSION OF Ki-67 IN SEBORRHEIC KERATOSES
Authors: Praharsini IG. A .A. , Widiana I.G Raka 
Published: September 2017

Cellular proliferation of KS will increase secretion of Â derivate keratinocyte Â factorsÂ that is stem cell factor (SCF) Â which is a Â melanogenic cytokinesÂ that causes proliferation and differentiation of cells and increase the transcription of tyrosinase enzyme (TYR). It is not clear whether SCF and TYR play a role in cellular proliferation of SK. This study aims to determine the relationship between expressions of SCF and TYR Â with Â expression of Ki-67 as a proliferative marker in seborrheic keratosis.This study used a cross sectional design with a sample of 67 SK lesions from patients who visited the Clinic of Dermato-Venerology Â Sanglah hospital, Denpasar. Statistical analysis in this study used linear regression test to analyze the relationship between the independent variables (expression of SCF and TYR ) and the dependent variable ( Ki - 67 ).Stem Cell Factor expression was found to be positively correlated with the expression of Ki-67 (r=0,61, p<0,001) with regression coefficient 0.61 (t=6.22, p<0.001) and constant -49. Correspondingly, the result indicated positive correlation between tyrosinase expression and Ki-67 (r=0,61, p<0,001) with regression coefficient 0.755 (t=8.86, p<0.001) and constant -6.02. Â This study showed a strongly and positive correlation between the expressions of SCF, TYR with Â expression of K -67 which is a marker of cell proliferation.
Amplification of 0.7 Kb Fragment katG Gene from Clinical Multi-Drug Resistant Tuberculosis (MDR-TB) Isolate in Bali
Authors: Dwiputri A. W. , Ratnayani K. , Yowani S. C. 
Published: September 2017

The last decade has seen a particular increase in the occurrence of drug-resistant (DR-TB) and multi-DR strains, such as Isoniazid (INH) resistant strains of M. tuberculosis. Â INH resistance is more frequently associated with mutations in the katG gene. Detection of katG gene mutations can be performed by PCR technique, followed by sequences. The aim of this study is to amplify katG gene region (0,7 Kb) from clinical isolate of MDR-TB in Bali. DNA isolation for PCR was done by Boom method and katG gene amplification was performed under the following conditions: predenaturation at 95oC for 15 min; fourty cycles of denaturation at 94oC for 1 min, annealing at 56oC for 1 min, extension at 72oC for 2 min; final extension at 72oC for 10 min. The amplicons were detected by 1,5% agarose gel electrophoresis and showed a specific band size at 0.7 kb. This suggests that the fragment of katG gene has been successfully amplified in these area.
Functional Imaging of Paragangliomas with an Emphasis on Von Hippel–Lindau-Associated Disease: A Mini Review
Authors: Ilias Ioannis , Meristoudis Georgios 
Published: September 2017

Few reports have presented data and results on functional (i.e., nuclear medicine) imaging of paragangliomas and pheochromocytomas (PGLs/PHEOs) for von Hippel–Lindau (VHL) patients. Nuclear medicine localization modalities for chromaffin tumors can be specific or nonspecific. Specific methods make use of the expression of the human norepinephrine transporter (hNET) and vesicular monoamine transporters (VMATs) by these tumors. These permit the use of radiolabeled ligands that enter the synthesis and storage pathway of catecholamines. Nonspecific methods are not related to the synthesis, uptake, or storage of catecholamines but make use of the tumors’ high glucose metabolism or expression of somatostatin receptors. Consensuses and guidelines suggest that metastatic and sporadic PHEOs/PGLs in VHL patients (as in patients with chromaffin tumors of yet unknown genotype) should be evaluated first with 18F-dihydroxyphenylalanine (18F-DOPA) positron emission tomography/computed tomography (PET/CT). The functional imaging of second choice is 123I-metaiodobenzylguanidine (123I-MIBG) for PHEOs in VHL patients. 123I-MIBG, 68Ga-DOTATATE/DOTATOC/DOTANOC PET/CT, or 18F-fluorodeoxyglucose (18F-FDG) PET/CT can be a second choice of functional imaging for PGLs in VHL patients.
APLIKASI DATA PENGINDERAAN JAUH DAN SIG DALAM PEMILIHAN TAPAK POTENSIAL PLTN KALIMANTAN BARAT
Authors: Susiati Heni , S.B.S. Yarianto , Anzhar Kurnia , Kironi Bansyah , Mellawati June 
Published: September 2017

ABSTRAK APLIKASI DATA PENGINDERAAN JAUH DAN SIG DALAM PEMILIHAN TAPAK POTENSIAL PLTN KALIMANTAN BARAT. Untuk inventarisasi tapak potensial PLTN di wilayah pesisir Kalimantan Barat telah dilakukan penelitian di sepanjang pesisir di Provinsi Kalimantan Barat berdasar kriteria yang berlaku dalam pemilihan tapak PLTN. Tujuan penelitian adalah untuk mendapatkan tapak potensial PLTN di wilayah pesisir provinsi Kalimantan Barat berdasarkan kriteria yang berlaku. Metode penelitian meliputi pengumpulan data primer, interpretasi data penginderaan jauh dan analisis pembobotan berbasis sistem informasi geografi. Hasil pemeringkatan diperoleh 6 tapak potensial PLTN yang sesuai, yaitu: peringkat pertama di desa Air Besar, kecamatan Kendawangan, peringkat kedua di desa Sie, kecamatan Simpang, kabupaten Kayong Utara, peringkat ketiga ada di desa Sungai Kanan, Kecamatan Muara, kabupaten Ketapang, peringkat keempat berada di desa Sungai Nanjung, peringkat kelima berada di desa Kendawangan Kanan, kabupaten Ketapang dan peringkat keenam terdapat di desa Matang, kecamatan Paloh, kabupaten Sambas. Hasil analisis kesesuaian lahan menunjukkan bahwa semua tapak yang terpilih telah memenuhi kriteria umum dan khusus dalam pemilihan tapak potensial PLTN, antara lain: bukan merupakan lahan gambut, serta jauh dari pemukiman. Kata kunci: tapak potensial, PLTN, Penginderaan Jauh, SIG, matching ABSTRACT REMOTE SENSING AND GIS APPLICATION IN THE A NPP POTENTIAL SITE SELECTION AT WEST KALIMANTAN. To inventory of potential site of nuclear power plants in the coastal areas of West Kalimantan has conducted research along the coast in the province of West Kalimantan based on the applicable criteria in the selection of nuclear power plant site. The research objective is to get the potential site of nuclear power plants in the coastal areas of West Kalimantan province based criteria and a weighting system based on geographic information and matching. The rating results obtained 6 appropriate location to be used as a potential site of nuclear power plants, namely in sequence as follows: first place in the village of Air Besar, sub Kendawangan, ranked 2nd in the village Sie, sub Simpang, district North Kayong, ranking third in the village Sungai Kanan, Muara, Ketapang district, as well as to the fourth rank in the village Nanjung River, ranked fifth in the village Kendawangan, Ketapang district and ranked sixth in the coastal areas located in the village of Matang, sub Paloh, Sambas district. The results of land suitability analysis showed that all selected site have met the general and specific criteria in the selection of a potential site of nuclear power plants, among others: not a peat land, as well as away from the settlements. Keywords: potential site, NPP, Remote Sensing, GIS, matching
ANALISIS KELAYAKAN FINANSIAL PROYEK PLTN SMR DI INDONESIA DENGAN MEMPERTIMBANGKAN VARIABEL KETIDAKPASTIAN
Authors: Nuryanti Nuryanti , Suparman Suparman , Nasrullah Mochamad , Amitayani Elok S. , Widodo Wiku Lulus 
Published: September 2017

ABSTRAK ANALISIS KELAYAKAN FINANSIAL PROYEK PLTN SMR DI INDONESIA DENGAN MEMPERTIMBANGKAN VARIABEL KETIDAKPASTIAN. SMR merupakan salah satu alternatif mengatasi ketergantungan wilayah Luar Jawa Bali terhadap PLTD. Masalah yang sangat krusial dalam proyek PLTN (termasuk SMR) adalah finansial, terkait dengan sifat padat modal pada proyek ini. Selain itu, pada proyek PLTN SMR juga dimungkinkan terjadinya beberapa variabel ketidakpastian. Penelitian ini bertujuan untuk melakukan analisis kelayakan finansial proyek PLTN SMR dengan mengakomodasi kemungkinan terjadinya variabel ketidakpastian tersebut. Metodologi yang digunakan adalah analisis probabilistik yang dilakukan dengan teknik Monte Carlo. Teknik ini mensimulasikan keterkaitan antara variabel-variabel ketidakpastian dengan indikator kelayakan finansial proyek. Hasil penelitian menunjukkan bahwa pada pendekatan probabilistik proyek PLTN SMR dinilai layak pada “most probable value” harga jual listrik sebesar 15 cents/kWh, ditunjukkan dengan rata-rata NPV yang positif (US$ 135.324.004) dan rata-rata kedua nilai IRR yang lebih dari MARR (IRR proyek = 10,65%, IRR Equity = 14,29%, sementara MARR = 10%). Probabilitas ditolaknya proyek PLTN SMR adalah sekitar 20%. Tiga variabel utama yang paling berpengaruh dalam proyek adalah: harga jual listrik, biaya investasi dan tingkat inflasi. Kata kunci: kelayakan finansial, PLTN SMR, variabel ketidakpastian, NPV, IRR ABSTRACT FINANCIAL FEASIBILITY ANALYSIS ON SMALL MEDIUM REACTOR NUCLEAR POWER PLANT (SMR NPP) PROJECT IN INDONESIA UNDER UNCERTAINTY. NPP SMR is one alternative to overcome the Outside Java Bali region's dependence on diesel power plant. One crucial issue in the NPP project (including SMR) would be financing, associated with the capital-intensive nature of the project. In addition, the SMR NPP project also be vulnerable in occurrence of some uncertainties. Therefore, this study aimed to analyze the financial feasibility of SMR NPP project by accomadating the possibility of the uncertainties. The methodology used is probabilistic analysis which was performed by Monte Carlo technique. This technique simulates the relationship between the uncertainty variables with financial feasibility indicators. The results showed that in probabilistic approach, SMR NPP project is considered feasible on the "most probable value" of electricity selling price of 15 cents/kWh, indicated by positive average value of NPV (US$ 135,324,004) and the average value of both of IRRs are bigger than MARR (IRR project = 10.65%, IRR Equity = 14.29%, while MARR = 10%). The probability of rejection of the SMR project was about 20%. The three main variables that are most influential in the project were: selling price of electricity, invesment cost and inflation rate. Keywords: financial feasibility, SMR NPP, uncertainties, NPV, IRR
Optimasi Aliran Daya pada Sistem Kelistrikan Opsi Nuklir Berdasarkan Multi-Objective Function: Fuel Cost dan Flat Voltage Profile
Authors: Setya Budi Rizki Firmansyah , Sarjiya Sarjiya , Pramono Sasongko Hadi 
Published: September 2017

Tujuan dari pengoperasian sistem tenaga listrik adalah untuk memasok daya dengan kualitas baik dan biaya pembangkitan seminimal mungkin. Kualitas yang baik membutuhkan biaya yang lebih besar, sehingga untuk mencapai tujuan tersebut diperlukan optimasi dengan fungsi obyektif yang bertujuan untuk memaksimalkan kualitas sekaligus meminimalkan biaya. Penelitian ini bertujuanuntuk mendapatkan kondisi aliran daya optimal atau optimal power flow (OPF) dari segi biaya pembangkitan maupun kualitas tenaga listrik di suatu sistem kelistrikan dengan opsi nuklir pada waktu beban puncak dengan menggabungkan fungsi obyektif fuel cost dan flat voltage profile. Fungsi obyektif fuel cost bertujuan untuk meminimalkan biaya pembangkitan sedangkan fungsi obyektif flat voltage profile bertujuan untuk memaksimalkan kualitas dengan meminimalkan perbedaan/variasi tegangan dalam sebuah sistem. Penelitian dilakukan melalui studi literatur, penentuan fungsi obyektif optimasi, penggabungan fungsi objektif, simulasi menggunakan contoh kasus dan analisis sensitivitas. Contoh kasus menggunakan sistem IEEE 9 Bus yang telah ditambahkan fungsi bahan bakar PLTN, PLTU, dan PLTG. Simulasi menggunakan program bantu ETAP 12.6.0. Analisis sensitivitas dilakukan dengan menggunakan nilai pembobotan dari 0-100% untuk tiap fungsi obyektif. Hasil simulasi menunjukkan bahwa OPF dicapai pada faktor pembebanan 60% untuk fuel cost dan 40% untuk flat voltage profile. Biaya pembangkitan padakondisi optimal tersebut sebesar 7266 US$/jam dengan selisih tegangan maksimum minimumnya sebesar 2,85%. Pada sistem ini PLTU membangkitkan daya sebesar 133,2 MW + 22,1 MVar dan PLTG sebesar 80,7 MW + 13,8 MVar. Sedangkan PLTN membangkitkan daya sebesar 89,9 MW + 12,9 Mvar dan akan ekonomis jika membangkitkan daya kurang dari 90 MW.
Subjetividades y agencias que emergen en la periferia urbana: Reflexiones sobre un barrio de Valencia
Authors: Moncusí Ferré Albert 
Published: September 2017

Els Orriols es un barrio popular de Valencia reconocido por su carácter multicultural, donde se está produciendo una movilización que trata de redefinir su imagen y contrarrestar aspectos que afectan negativamente a las condiciones de vida de sus vecinos y vecinas. Este texto se acerca al caso concreto de ese barrio y esa movilización para subrayar la pertinencia y potencial de la etnografía en contextos urbanos, en especial a la hora de aprehender la emergencia de subjetividades y formas de agencia, en procesos comunitarios. La etnografía en curso pone encima de la mesa manifestaciones de subjetividades y vías de agencia como son la evocación de la memoria, la expresión de temor o miedo, proyectos de futuro, expresiones de igualación y ritualización de la comunidad barrial.
El travestismo y la androgenización en las fiestas de moros y cristianos. Una mirada desde la dimensión dialógica
Authors: Martínez Pozo Miguel Ángel 
Published: September 2017

Resumen: Las fiestas de moros y cristianos, en las últimas décadas del siglo XX y entrado el siglo XXI, han evolucionado hacia una búsqueda de valores contemporáneos donde, poco a poco, de manera subconsciente por parte de sus protagonistas, han ido rompiendo y erradicando estereotipos pre construidos e institucionalizados e introduciendo aspectos y cambios acordes con los momentos en los que vivimos. Hoy día, la fiesta, como soporte de las artes, está íntimamente ligada a las artes escénicas y plásticas donde se establece una performance artística. A través del siguiente artículo nos introduciremos en los tipos de travestismos existentes dentro de las fiestas de moros y cristianos e incluso en la propia androgenización como parte de un engaño, simulación, simulacro o como mera necesidad de transformarse para subsistir o bien integrarse dentro de la propia fiesta.

Palabras clave: artes escénicas | artes plásticas | travestismo | moros y cristianos | androgenización |
Análisis y evolución de los delitos de odio en España (2011-2015)
Authors: López Ortega Ana I. 
Published: September 2017

El artículo realiza por primera vez una radiografía de los delitos de odio en España a partir de un análisis exhaustivo de la evolución de las cifras en los últimos cinco años. En 2015 se han contabilizado 1.285 delitos de odio y 1.273 víctimas. Los agresores son mayoritariamente varones, entre 18 y 35 años y ocho de cada diez son nacionales. El 52% de las víctimas son mujeres y han nacido en España, aunque cada vez más el origen de la víctima es más diverso tanto en su país de origen como en su religión
Para su análisis, se ha utilizado metodología cuantitativa y se han seleccionado variables relevantes como la edad, el sexo, la nacionalidad y la distribución de los delitos por comunidades autónomas. El estudio aporta nuevas cifras de esta tipología de delitos en el caso español y apunta las posibles causas de su crecimiento.
Aprendizaje de las ciencias basado en proyectos: del contexto a la acción
Authors: Sanmarti Puig Neus , Márquez Bargalló Conxita 
Published: September 2017

Actualmente, se están impulsando numerosas metodologías didácticas basadas en el trabajo por proyectos. En relación a ellas se identifican algunas características comunes, aunque en la práctica se conceptualizan y aplican de manera muy diversa. Las diferencias principales radican en cómo se entiende qué es un contexto idóneo y cómo se selecciona, en los objetivos de aprendizaje relacionados con los conocimientos conceptuales a construir, en la forma de concebir y aplicar un proceso de investigación y, también, en qué se entiende por actuar y cómo se promueve. En el artículo se reflexiona, en relación a estos aspectos, sobre las concepciones y prácticas desde el punto de vista de la competencia científica, y sobre lo que se sabe y sobre lo que aún son campos abiertos en didáctica de las ciencias.
Bird responses to habitat change in the karst area of Bantimurung Bulusaraung National Park
Authors: Putri Indra A.S.L.P. , Broto Bayu Wisnu , Ansari Fajri 
Published: September 2017

Birds are useful bioindicators to habitat changes. This study aims to determine the responses of birds to habitat change at Maros-Pangkep karst area, Bantimurung-Bulusaraung National Park. The research was carried out in three disturbance degrees (core-zone, wilderness-zone, and the community-gardens), which represents minimal, middle, and high interference level. A modified square-line method was used to observe vegetation of bird habitat. Point count method was used to observe bird population. Data of the bird habitat vegetation was analyzed using vegetation density. The difference of vegetation composition was analyzed using Sorensen-similarity index. Data of the bird was analyzed using abundance, and indexes of Shannon-Weinner diversity, Simpson dominance, Pielou evenness, and Margalef species richness. Significant differences between the number of the individual bird were tested using one-way ANOVA, Tukey-Bonferroni test. The results showed that birds living in karst were sensitive to habitat changes. Birds responded through reducing the number of individuals and species, shifting the species of bird that has high importance value index from low tolerance species to high tolerance species. Birds also responded by shifting the feeding guild that has high important value index from frugivore to frugivore-insectivore and then to granivore, decreasing the number of bird species with large body size, reducing the number of bird species that need a special location to build nest. Considering that Maros-Pangkep Karst has vital roles, scientific values, and biodiversity richness, it is necessary to involve all stakeholders to maintain its sustainability, including the establishment of entire Maros-Pangkep Karst area as the karst-landscape area.
Optimal rotation of sengon plantation in afforestation project: Review on research results of Suharlan 1975
Authors: Indrajaya Yonky 
Published: September 2017

Forests play an important role in climate change mitigation by absorbing carbon dioxide in the atmosphere. Additional revenue from carbon credits may change the optimal management of plantation forest. This research aims to analyze the optimal rotation of joint production of timber and carbon sequestration of sengon stand in Java. The method used in this research is the profit maximization of forest stand obtained from wood sales and carbon credits (i.e. Hartman rule as a modification of Faustmann rule). The results of this study showed that (1) the biological rotation of sengon forest in site quality (SQ) III and IV are 6 and 5 years respectively, (2) Financial rotations of sengon forest in SQ III and IV are 8 and 6 years respectively, and (3) Additonal income from carbon sales in afforestation project will not lengthen the optimal rotation of sengon plantation.