bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dynamic changes in macrophage polarization during the resolution phase of periodontal disease
Authors: Uttamani Juhi R. , Kulkarni Varun , Valverde Araceli , Naqvi Raza Ali , Van Dyke Thomas , Nares Salvador , Naqvi Afsar R. 
Published: October 2024

AbstractAimPolarization of macrophages (Mφ) is a well‐controlled axis with considerable consequences in both the pro‐inflammatory and resolution phases of inflammation. We aimed to determine if periodontal therapy may instigate M1 to M2 Mφ polarization favoring resolution of inflammation within periodontal tissues.MethodsGingival biopsies were excised from subjects diagnosed with Stage III, Grade B periodontitis before and 4–6 weeks after nonsurgical periodontal therapy. Total RNA was isolated and pro‐ and anti‐inflammatory markers associated with Mφ polarization assessed by RT‐qPCR. Mice were subject to ligature‐induced periodontitis and gingival tissues collected after 8 days in‐situ or 10 days after ligature removal and M1 and M2 Mφ markers examined by RT‐qPCR and flow cytometry.ResultsIn human samples, improvement in clinical parameters posttherapy correlates with reduced bacterial burden, downregulation in M1 (TNF‐α, STAT1, CXCL10, and miR‐155), and elevated levels of M2 (STAT6, TGM2, CCL22, and IL‐10) Mφ markers. In a murine model of resolution of LIP, we observed reduced levels of M1 Mφ markers cox2, iNOS2, F4/80+CD80+, and F4/80+CD86+ and elevated levels of M2‐like Mφ markers tgm2, arg1, F4/80+CD206+ and F4/80+CD163+ corroborated human findings.ConclusionResolution of periodontal inflammation is associated with M1 to M2 Mφ polarization after nonsurgical periodontal therapy. Assessment of Mφ markers can provide relevant clinical information on the successful response of periodontal therapy and may be used to target nonresponders.
Prevention of intrauterine balloon displacement in patients with postpartum hemorrhage: A narrative review
Authors: Cassardo Ottavio , Orsi Michele , Cesano Nicola , Iurlaro Enrico , Perugino Giuseppe , Cetin Irene 
Published: October 2024

AbstractPostpartum hemorrhage (PPH) remains a significant complication of pregnancy globally, with uterine atony accounting for the great majority of cases. Second‐line hemostatic strategies such as uterine balloon tamponade play a crucial role in managing refractory hemorrhage. Despite its effectiveness, the phenomenon of balloon displacement poses a challenge to PPH management, often leading to treatment failure. Various techniques have been proposed to address this issue, including vaginal packing, cervical cerclage, fixation to the abdominal wall, holding the cervix with ring forceps, and suspending the balloon with cervical sutures. Each method has its advantages and limitations, influencing its suitability in different clinical scenarios. Understanding these techniques may be useful to optimize and improve the management of PPH and maternal outcomes. This review provides a comprehensive summary of these strategies, their mechanisms, and their clinical implications, aiming to guide healthcare providers in choosing the most appropriate approach for individual cases of PPH.
What role, if any, should phonics play in a middle school or high school? The answer may surprise you
Authors: Shanahan Timothy 
Published: October 2024

AbstractResearch shows little benefit from phonics instruction in Grades 2 through 12. However, more recent studies show that students who fall below a decoding threshold fail to benefit from other kinds of reading instruction. This exploration of the evidence suggests that these students are likely to need support in the reading and spelling of multisyllabic words and words with common morphological elements. Explicit instruction with a focus on the decoding, spelling, and meaning of such words would make a lot of sense.
Association between victimization and perpetration of cyberhate: The moderating role of social dominance orientation
Authors: Naranjo‐Pou Susett , Zych Izabela 
Published: October 2024

AbstractIntroductionExpressions of cyberhate motivated by characteristics such as gender, ethnicity, and religious beliefs are now present and prevalent on social networks. Past research, both in online and offline contexts, has identified that, although there may be an overlap between victims and perpetrators of violence; this is not always the case. Nevertheless, the number of studies focused on variables that moderate the relation between victimization and perpetration is still low. The current study aims at analyzing the relation between cyberhate victimization and perpetration and the potential moderating role of social dominance on this relation.MethodDuring the 2019/2020 school year in Andalusia, Spain, a prospective longitudinal study was implemented. The study used a representative sample of 1498 adolescents enrolled in compulsory secondary education in the first wave (51.8% female; Mage = 13.58) and 1195 adolescents in the second wave (53.2% female; Mage = 14.04). Surveys administrated to adolescents were used for data collection.ResultsThe findings revealed a positive correlation between cyberhate victimization and perpetration. They supported the notion that social dominance not only predicted the perpetration of cyberhate several months later, but also its moderating effect on the relation between cyberhate victimization and perpetration. Cyberhate victims who reported higher levels of social dominance were more likely to become perpetrators several months later.ConclusionResults suggest the need to implement preventive programs considering the influence of social dominance. These strategies could promote social equality and help to interrupt the cycle in which victims can become perpetrators of cyberhate.
Noncoding RNA Linc00475 promotes the proliferation of colorectal cancer cells by targeting miR‐107/CDK6 axis
Authors: Li Dongqing , Peng Mingya , Zhou Juying 
Published: October 2024

AbstractColorectal cancer (CRC) represents a substantial challenge to public health. Despite extensive research, the pathogenesis of CRC is not yet fully elucidated, hindering the development of effective therapeutic strategies. Recent advancements have underscored the importance of Non‐coding RNAs in tumor biology. Our research identified a significant upregulation of Linc00475 in CRC, which correlated with reduced survival rates among CRC patients. Consequently, this study aimed to elucidate the mechanisms by which Linc00475 contributed to CRC progression. Employing a comprehensive array of experimental techniques—including CCK‐8 assays, colony formation assays, flow cytometry, quantitative PCR (qPCR), western blot analysis, and in vivo tumorigenesis assays—we have demonstrated that Linc00475 enhances CRC cell proliferation. Further analysis revealed that Linc00475 directly interacted with miR‐107, leading to its downregulation. Moreover, our findings confirmed that miR‐107 directly targeted CDK6, which was markedly downregulated following Linc00475 silencing. In vivo experiments further indicated that the silencing of Linc00475 markedly inhibited the proliferation of CRC cells. Collectively, our findings suggested that Linc00475 facilitated CRC cell proliferation through the regulation of the miR‐107/CDK6 axis, thereby providing a novel perspective for understanding the molecular mechanisms underlying CRC development.
Sinensetin inhibits the movement ability and tumor immune microenvironment of non‐small cell lung cancer through the inactivation of AKT/β‐catenin axis
Authors: Shi Zhenliang , Shen Yimeng , Liu Xin , Zhang Sipei 
Published: October 2024

AbstractAlthough current treatment strategies have improved clinical outcomes of non‐small cell lung cancer (NSCLC) patients, side effect and prognosis remain a hindrance. Thus, safer and more effective therapeutical drugs are needed for NSCLC. Sinensetin (Sin) is a flavonoid from citrus fruits, which exhibits antitumor effect on diverse cancers. However, the effect and mechanism of Sin on NSCLC remain unknown. In this study, NSCLC cell lines, and tumor‐bearing mice were treated with Sin. The effect and mechanism of Sin were addressed using cell counting kit‐8, transwell, enzyme‐linked immunosorbent assay, hematoxylin and eosin, immunohistochemistry, and western blot analysis assays in both cell and animal models. Sin reduced the cell viability of A549 and H1299, with the IC50 of 81.46 µM and 93.15 µM, respectively. Sin decreased invaded cell numbers, the expression of N‐cadherin and vascular endothelial growth factor A (VEGFA), while increased the E‐cadherin level, the cytotoxicity of CD8+ T cells, and the concentration of interferon‐γ (IFN‐γ), interleukin‐2 (IL‐2), and tumor necrosis factor‐α (TNF‐α) in NSCLC cells. Mechanistically, Sin declined the expression of protein kinase B (AKT)/β‐catenin pathway, which was restored with the application of SC79, an activator of AKT. The inhibitory role of Sin in NSCLC cell proliferation, invasion, epithelial‐mesenchymal transition (EMT) and immune escape was reversed by the management of SC79. In vivo, Sin reduced tumor size and weight, and the expression of N‐cadherin, VEGFA, and AKT/β‐catenin pathway, but enhanced the level of E‐cadherin and IFN‐γ. Taken together, Sin suppressed cell growth, invasion, EMT and immune escape via AKT/β‐catenin pathway in NSCLC.
RHO subfamily of small GTPases in the development and function of hematopoietic cells
Authors: de Castro Sampaio Stephany Suelen , Ramalho Maria Carolina Clares , de Souza Caroline Santos , de Almeida Rodrigues Beatriz , de Mendonça Guilherme Ramos Sales , Lazarini Mariana 
Published: October 2024

AbstractRHOA, RHOB, and RHOC comprise a subfamily of RHO GTPase proteins famed for controlling cytoskeletal dynamics. RHO proteins operate downstream of multiple signals emerging from the microenvironment, leading to diverse cell responses, such as proliferation, adhesion, and migration. Therefore, RHO signaling has been centrally placed in the regulation of blood cells. Despite their high homology, unique roles of RHOA, RHOB, and RHOC have been described in hematopoietic cells. In this article, we overview the contribution of RHO proteins in the development and function of each blood cell lineage. Additionally, we highlight the aberrations of the RHO signaling pathways found in hematological malignancies, providing clues for the identification of new therapeutic targets.
Anatomic physeal‐sparing MPFL reconstruction in skeletally immature patients shows favourable outcomes at a minimum of 24‐month follow‐up
Authors: Ntagiopoulos Panagiotis , Pozzi Pierrenzo , Kalinterakis Georgios , Fligkos Dimitris , Dimou Triantafyllia , Compagnoni Riccardo , Ferrua Paolo , Randelli Pietro Simone 
Published: October 2024

AbstractPurposeRecurrent patellar dislocation is a prevalent orthopaedic issue among active paediatric and adolescent populations. Bony surgical procedures are not recommended in growing patients; therefore, the focus of surgery is on restoring the medial patellar ligaments, with different reconstructive techniques available. This retrospective case series focuses on the 2‐year outcomes of medial patellofemoral ligament (MPFL) reconstruction in skeletally immature patients with open physis.MethodsTwenty‐four consecutive patients with patellofemoral instability and open growth plates underwent anatomic MPFL reconstruction with a physeal‐sparing technique. All subjects have had more than three episodes of true patellar dislocations. Preoperative radiographic examination included anteroposterior and lateral views to assess patella alta and limb alignment. Magnetic resonance imaging was performed to evaluate trochlear dysplasia and tibial tubercle–trochlear groove (TT–TG) distance. The patients were questioned regarding complications and clinical outcomes using the visual analogue scale (VAS), Kujala and Paediatric International Knee Documentation Committee (Pedi‐IKDC) score. Variables were evaluated using paired t test with significance at p < 0.05.ResultsThe mean age at the time of operation was 13.04 years (9–16 years). The cohort was followed for a mean duration of 38.66 months (24–86 months). The mean time from injury to surgery was 50.45 days (16–80 days). No growth arrest, limb‐length discrepancies or angular deformities were observed post‐operatively during the whole follow‐up period. No patellar re‐dislocations were recorded throughout the study period. The VAS score improved significantly from 5.67 (4–8) to 1.88 (0–4) (p < 0.01). The Kujala score improved significantly from 64.67 (44–81) preoperatively to 87.58 (77–100) post‐operatively (p < 0.01). The Pedi‐IKDC also increased significantly from 58.81 (34.80–77.70) preoperatively to 90.64 (70.70–100) post‐operatively (p < 0.01). The vast majority of patients (87.5%) returned to their pre‐injury activity level. Boys scored better than girls in VAS, Pedi‐IKDC and Kujala score post‐operatively, but these differences were not statistically significant.ConclusionPhyseal‐sparing MPFL reconstruction in children and adolescents yields excellent midterm results and allows patients to return to sports without redislocation of the patella. Boys scored better than girls in VAS, Pedi‐IKDC and Kujala score post‐operatively, but these differences were not statistically significant.Level of EvidenceIV: case series with no comparative group.
Arthroscopic treatment for femoroacetabular impingement yields favourable patient‐reported outcomes and method survivorship at 10‐year follow‐up
Authors: Nikou Sarantos , Sturesson Joel , Lindman Ida , Karlsson Louise , Öhlin Axel , Senorski Eric Hamrin , Sansone Mikael 
Published: October 2024

ABSTRACTPurposeTo compare the outcomes of hip arthroscopy for femoroacetabular impingement syndrome (FAIS) preoperatively and at minimum 10‐year follow‐up using patient‐reported outcome measures (PROMs).MethodsA total of 128 patients with FAIS were prospectively included. The patients underwent arthroscopic surgery for FAIS between 2011 and 2013 and had a minimum of 10‐year follow‐up. The International Hip Outcome Tool short version (iHOT‐12) was the primary outcome. Secondary outcomes were the Copenhagen Hip and Groin Outcome Score (HAGOS), the European Quality of Life‐5 Dimensions Questionnaire (EQ‐5D), the European Quality visual analogue scale (EQ VAS), the Hip Sports Activity Scale (HSAS) for physical activity level, the Visual Analogue Scale (VAS) for overall hip function and a single question regarding overall satisfaction with the surgery. The Wilcoxon signed rank test was used to compare pre‐ and postoperative PROMs.ResultsThere was a significant improvement (p < 0.001) of iHOT‐12, HAGOS subscales, EQ‐5D, EQ VAS and VAS for overall hip function. A total of 83% of the patients were satisfied with their surgery. The survivorship of hip arthroscopy, defined as nonconversion to total hip arthroplasty (THA), at the end of the follow‐up period was 77%.ConclusionPatients undergoing arthroscopic treatment for FAIS reported statistically significant and clinically relevant improved outcomes at 10‐year follow‐up.Level of EvidenceCase series, level IV.
Soil Organic Carbon Stocks Depend Differently on Physicochemical Features in Subtropical Seasonally Flooded Wetland and Non‐flooded Shoreland Forest
Authors: Yuan Zhifen , Fu Chun , Liu Jie , Leng Fei , Weihrauch Christoph , Rinklebe Jörg , Rousk Johannes , Zheng Bofu , Shen Ruichang 
Published: October 2024

ABSTRACTIn recent years, an increasing number of ecosystems are threatened by seasonal flooding, changing non‐flooded shoreland (NF) into seasonally flooded wetland (SF), but the consequences of this hydrological change for soil organic carbon (SOC) dynamics remain unknown. In this study, we investigated how the SOC content was determined by flooding duration and soil physicochemical variables in adjacent SF and NF at six depths (0–10 cm, 10–20 cm, 20–30 cm, 30–50 cm, 50–70 cm, and 70–100 cm) at Shengjin Lake in subtropical China. Soil physicochemistry and SOC composition were analyzed, and Fourier‐transformed infrared spectroscopy (FTIR) was used to resolve the SOC composition. Neither SOC content nor the vertical distribution of SOC was distinguishable between the sites. However, FTIR data revealed that plant‐originated aliphatics and amides were higher at NF than SF sites, with the opposite pattern for aromatics. At SF sites, SOC content was positively affected by soil moisture and flooding duration and was negatively impacted by soil particle size at most soil layers. At NF sites, SOC content was mainly affected by silt and total Fe at the top 20 cm soil, while a higher fraction of plant‐derived labile C was positively correlated to SOC contents at 30–100 cm depth. The results hence indicated a strong effect of seasonal flooding on SOC dynamics in terrestrial ecosystems. SOC stabilization induced by low mineralization and high adsorption played a central role at SF sites, while SOC formation through plant input was more important at NF sites. Our findings suggest that management strategies designed to conserve SOC will need to be site‐specific.
Stereoselectivity Control Interplay in Racemic Lactide Polymerization by Achiral Al‐Salen Complexes
Authors: Moccia Serena , D’ Alterio Massimo Christian , Romano Eugenio , De Rosa Claudio , Talarico Giovanni 
Published: October 2024

AbstractThe origin of stereocontrol in ring opening polymerization (ROP) of racemic lactide (rac‐LA) promoted by achiral aluminium‐based catalysts has been explained through DFT calculations combined with a molecular descriptor (%VBur) and the activation strain model (ASM‐NEDA) analysis. The proposed chain end control (CEC) model suggests that the ligand framework adopts a chiral configuration mimicking the enantiomorphic site control (ESC) while also incorporating control of the last inserted monomer unit. It is found that the ligand wrapping mode around the aluminium centre is dictated by the monomer configuration (R,R‐LA and S,S‐LA). A good correlation with experimental data is achieved only when accounting for the ligand dynamic features and its steric influences, as highlighted by %VBur steric maps and ASM‐NEDA analysis. Understanding the ESC and CEC interplay is an important target for obtaining stereoselective ROP polymerization for the synthesis of biodegradable materials with tailored properties.
Decoupling for microstrip antenna array based on characteristic mode analysis
Authors: Si Wei , Han Guodong , Liu Yakun 
Published: October 2024

AbstractA new decoupling method for microstrip antenna arrays has been proposed in this paper, which is based on characteristic mode analysis. This method works by suppressing the nonworking mode that contributes the most to mutual coupling. An eight‐element microstrip antenna array is designed as the reference antenna, and for this antenna, mode suppression is achieved by etching gaps on the patch and adding metal columns between the patch and the ground. The antenna array after the mode suppression is fabricated and measured. The results show that the measured S34 after the mode suppression is below −21 dB, whereas the simulated S34 of the reference antenna array is about −15 dB. This indicated a 7–10.5 dB reduction in coupling across the band. Additionally, the measured ActiveS3 after the mode suppression is still below −11 dB. Besides, the measured and simulated normalized array patterns after the mode suppression agree well at different frequencies.
Zinc as a potential prophylactic adjuvant therapy for prolonged hospitalization: A systematic review and meta‐analysis of an umbrella of randomized controlled trials
Authors: Atef Abdelsattar Ibrahim Hoda , Bendary Mohammed , Sabt Ahmed , Saad Khaled 
Published: October 2024

AbstractAimsThe present study evaluated the effect of oral zinc supplementation on shortening hospital length of stay.MethodsA systematic review was conducted for randomized control trials in patients who were hospitalized regardless of age and cause of admission. Studies were collected from PubMed, Web of Science, SCOPUS, and the Cochrane Library until July 2023. Results were compared between the zinc group and those who received a placebo and/or the standard therapy.ResultsEight studies were qualified for our meta‐analysis. Of the 1267 patients, 633 and 634 were in the zinc supplementation and control groups, respectively. The meta‐analysis found that oral zinc supplementation group experienced a lower length of hospital stay than the control group (mean difference, −0.43 days; 95% confidence interval, −0.65 to −0.22; P < 0.0001; heterogeneity, I2 = 20%).ConclusionThe administration of oral zinc supplements was associated with a slightly reduced duration of hospital stay.
Fuzzy Adaptive Sliding‐Mode Control Optimized by an Arithmetic Optimization Algorithm for a Quadrotor Drone With Chaotic Nonlinear Dynamics
Authors: Mahmoodabadi M. J. , Ibrahim M. Yousef 
Published: October 2024

ABSTRACTAn optimal fuzzy adaptive sliding mode controller (OFASMC) is introduced in the present paper for stabilizing a quadrotor drone with chaotic and nonlinear dynamics. At first, control efforts related to the motor torques of the regarded quadrotor drone are determined by the sliding mode procedure as the main stabilizer. Next, using the gradient descent formulation as well as the chain derivative rule, the control gains are adapted through the system states. Then, human knowledge‐based fuzzy systems are appropriately designed to set the control parameters for achieving more accurate results. The output errors and control efforts are minimized through the optimum values found for the effective coefficients of the controller by applying the Arithmetic Optimization Algorithm (AOA). Simulation results clearly illustrate the effectiveness of the introduced strategy to stabilize the quadrotor drone system with and without external disturbances.
Eating disorders, school professionals, and understanding family theory
Authors: Winter Emily L. , Mason Claire , Stillman Casey 
Published: October 2024

AbstractEating disorders have substantially risen in school‐aged youth, especially in a post‐pandemic world. Impacting children and adolescents across races, ethnicities, genders, and sexual orientations, prevalence rates suggest that eating disorders do not discriminate. Interestingly, despite the rising prevalence rates and increase of eating disorders, many school‐based mental health providers feel ill‐equipped to support children, adolescents, and their families seeking eating disorder treatment due to lack of knowledge or skill. Given the evidence‐based focus on family‐based treatment, many school‐based providers wonder what is best approach to support individuals within a school‐system, for how to best intertwine family‐based recommendations and collaboration with relevant outside clinicians. Given this uncertainty, this piece explores the role of school‐based mental health in supporting family‐based treatment, exploring two prominent systems theories and how providers within schools can adopt these approaches to most ethically aid students within the bounds of competence within a school setting.