bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embracing the ROFO Principle before Implementing Lean Production: A Chief Operating Officer’s Experiences and Reflections
Authors: Bee Goh Ah , Chakpitak Nopasit 
Published: December 2015

<div><strong>Purpose:</strong> The purpose of this paper is to highlight to CEOs (chief executive officers) that implementing the continuous improvement (CI) program requires a gradual overhaul of the entire organization. Nurturing the right working mindset is more important than hastily implementing the CI program to reap the benefits. A right working mindset can be achieved through the ROFO principle. This paper illustrates how Schaffner Thailand (ST) uses the ROFO principle to: i) coach the workers to develop the right working mindset and ii) implement Lean Production (LP) in the entire organization.</div><div> </div><div><strong>Methodology/Approach:</strong> This case study was carried out solely in ST company. It explains how the company coaches its employees to embrace ROFO principle in a systematic manner. A random sample of about 180 employees was taken to determine if there was a significant change in working mindset before and after the coaching of the ROFO principle.</div><div> </div><div><strong>Findings:</strong> There was a significant and positive mindset change after the coaching of the ROFO principle. Workers realize that the more they embrace the ROFO principle the better is the learning and the cooperative environment. LP was successfully implemented throughout the whole organization. LP continues to thrive in ST.</div><div> </div><div><strong>Originality/Value of paper:</strong> The first author originated the ROFO principle. It is both a management concept and tool. It is easily understood and is not a complex model. A great benefit of it is that it can be applied immediately to generate workforce commitment.</div>
Potential Involvement of Jagged1 in Metastatic Progression of Human Breast Carcinomas
Authors: Bednarz-Knoll Natalia , Efstathiou Antonia , Gotzhein Frauke , Wikman Harriet , Mueller Volkmar , Kang Yibin , Pantel Klaus 
Published: December 2015

Abstract

BACKGROUND
Jagged1, the ligand of Notch, has been shown to be involved in formation of bone metastases in an experimental study. Here, clinical relevance of Jagged1 expression in tumor progression was assessed in human breast carcinomas.

METHODS
Jagged1 expression was evaluated by immunohistochemistry in 228 tumor tissue samples and compared to clinicopathologic parameters and patients' outcomes. Furthermore, circulating tumor cells (CTCs) from peripheral blood of 100 unmatched metastatic cancer patients with progressive disease were enriched using Ficoll density gradient centrifugation and detected by pan-keratin/Jagged1/CD45 immunofluorescent staining.

RESULTS
Jagged1 expression was detected in 50% of 228 tumors. Jagged1 expression was correlated with higher tumor grade (P = 0.047), vascular invasion (P = 0.026), luminal B subtype (P = 0.016), overexpression of Her-2 (P = 0.001), high Ki-67 expression (P = 0.035), and aldehyde dehydrogenase 1 (ALDH1) positivity (P = 0.013). Jagged 1 expression indicated shorter disease-free survival (DFS) (P = 0.040) and metastasis-free survival (P = 0.048) in lymph node–negative breast cancer for which it was the only independent predictor of DFS (multivariate analysis, P = 0.046). Tumors characterized by the strongest Jagged1 staining intensity (7.5% of cases) correlated with lymph node positivity (P = 0.037), metastatic relapse (P = 0.049), and higher number of disseminated tumor cells in bone marrow aspirates (P = 0.041). Twenty-one unmatched metastatic breast cancer patients with progressive disease were positive for CTCs, and 85.7% of the CTCs also expressed Jagged1. The presence of Jagged1(+) CTCs was significantly associated with shorter progression-free survival in patients treated with bisphosphonates (P = 0.013).

CONCLUSIONS
Jagged1 expression characterizes more aggressive breast carcinoma and might be involved in tumor cell dissemination, metastatic progression, and resistance to bone-targeting therapy in breast cancer patients.
Development of a Low-Cost Electronic Wheelchair with Obstacle Avoidance Feature
Authors: Arboleda Edwin Romeroso , Alegre Mary Christine Tumambing , Idica Kathleen Felix 
Published: December 2015

A low-cost electronic wheelchair was designed and developed which can perform the similar functions and features as a commercially available wheelchair. It also provides obstacle avoidance capability as added value. The electronic wheelchair was realized by modification of a lightweight manual wheelchair. It uses two electric motors each of 320 W 24 V DC, 5-24 VDC 6 A H-bride drivers, and a 12 V 17 Ah rechargeable lead acid battery. It equipped with switches, joystick, infrared sensors and ultrasonic sensors. A GizduinoAtMega 328 microcontroller is used to read and interpret commands. User’s acceptance evaluation results shows that the developed low-cost wheelchair is able to receive and interpret commands provided by the joystick, detect if a person is seated on it, navigate to avoid obstacles as well as to detect edge and stairs. Technical evaluation result shows that on a flat surface it could move at the speed of around 39.9 m/minute without load and 32 m/minute with 80 kg load. At 10 degrees inclined surface, the maximum weight limit is 30 kg with the speed of 12 m/minute. At 20 degrees inclined surface, the maximum weight limit is 10 kg with the speed of 3 m/minute. Regarding cost, it is just a fraction of a cost compared to the commercially available model. Therefore, the developed wheelchair offers an option for potential users who cannot afford to buy the commercially available one.
ATP‐dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex
Authors: Liu Yaqi , Sung Sihyun , Kim Youngran , Li Fuyang , Gwon Gwanghyun , Jo Aera , Kim Ae‐Kyoung , Kim Taeyoon , Song Ok‐kyu , Lee Sang Eun , Cho Yunje 
Published: December 2015

AbstractATP‐dependent DNA end recognition and nucleolytic processing are central functions of the Mre11/Rad50 (MR) complex in DNA double‐strand break repair. However, it is still unclear how ATP binding and hydrolysis primes the MR function and regulates repair pathway choice in cells. Here, Methanococcus jannaschii MR‐ATPγS‐DNA structure reveals that the partly deformed DNA runs symmetrically across central groove between two ATPγS‐bound Rad50 nucleotide‐binding domains. Duplex DNA cannot access the Mre11 active site in the ATP‐free full‐length MR complex. ATP hydrolysis drives rotation of the nucleotide‐binding domain and induces the DNA melting so that the substrate DNA can access Mre11. Our findings suggest that the ATP hydrolysis‐driven conformational changes in both DNA and the MR complex coordinate the melting and endonuclease activity.
Chorioamnionitis and Culture-Confirmed, Early-Onset Neonatal Infections
Authors: Wortham Jonathan M. , Hansen Nellie I. , Schrag Stephanie J. , Hale Ellen , Van Meurs Krisa , Sánchez Pablo J. , Cantey Joseph B. , Faix Roger , Poindexter Brenda , Goldberg Ronald , Bizzarro Matthew , Frantz Ivan , Das Abhik , Benitz William E. , Shane Andi L. , Higgins Rosemary , Stoll Barbara J. ,   for the Eunice Kennedy Shriver NICHD Neonatal Research Network
Published: December 2015

BACKGROUND:
Current guidelines for prevention of neonatal group B streptococcal disease recommend diagnostic evaluations and empirical antibiotic therapy for well-appearing, chorioamnionitis-exposed newborns. Some clinicians question these recommendations, citing the decline in early-onset group B streptococcal disease rates since widespread intrapartum antibiotic prophylaxis implementation and potential antibiotic risks. We aimed to determine whether chorioamnionitis-exposed newborns with culture-confirmed, early-onset infections can be asymptomatic at birth.

METHODS:
Multicenter, prospective surveillance for early-onset neonatal infections was conducted during 2006–2009. Early-onset infection was defined as isolation of a pathogen from blood or cerebrospinal fluid collected ≤72 hours after birth. Maternal chorioamnionitis was defined by clinical diagnosis in the medical record or by histologic diagnosis by placental pathology. Hospital records of newborns with early-onset infections born to mothers with chorioamnionitis were reviewed retrospectively to determine symptom onset.

RESULTS:
Early-onset infections were diagnosed in 389 of 396 586 live births, including 232 (60%) chorioamnionitis-exposed newborns. Records for 229 were reviewed; 29 (13%) had no documented symptoms within 6 hours of birth, including 21 (9%) who remained asymptomatic at 72 hours. Intrapartum antibiotic prophylaxis exposure did not differ significantly between asymptomatic and symptomatic infants (76% vs 69%; P = .52). Assuming complete guideline implementation, we estimated that 60 to 1400 newborns would receive diagnostic evaluations and antibiotics for each infected asymptomatic newborn, depending on chorioamnionitis prevalence.

CONCLUSIONS:
Some infants born to mothers with chorioamnionitis may have no signs of sepsis at birth despite having culture-confirmed infections. Implementation of current clinical guidelines may result in early diagnosis, but large numbers of uninfected asymptomatic infants would be treated.
Feeding Post-Pyloromyotomy: A Meta-analysis
Authors: Sullivan Katrina J. , Chan Emily , Vincent Jennifer , Iqbal Mariam , Wayne Carolyn , Nasr Ahmed ,   for the Canadian Association of Paediatric Surgeons Evidence-Based Resource
Published: December 2015

CONTEXT:
Postoperative emesis is common after pyloromyotomy. Although postoperative feeding is likely to be an influencing factor, there is no consensus on optimal feeding.

OBJECTIVE:
To compare the effect of feeding regimens on clinical outcomes of infants after pyloromyotomy.

DATA SOURCES:
Cumulative Index to Nursing and Allied Health Literature, The Cochrane Central Register of Controlled Trials, Embase, and Medline.

STUDY SELECTION:
Two reviewers independently assessed studies for inclusion based on a priori inclusion criteria.

DATA EXTRACTION:
Data were extracted on methodological quality, general study and intervention characteristics, and clinical outcomes.

RESULTS:
Fourteen studies were included. Ad libitum feeding was associated with significantly shorter length of stay (LOS) when compared with structured feeding (mean difference [MD] −4.66; 95% confidence interval [CI], −8.38 to −0.95; P = .01). Although gradual feeding significantly decreased emesis episodes (MD −1.70; 95% CI, −2.17 to −1.23; P &lt; .00001), rapid feeding led to significantly shorter LOS (MD 22.05; 95% CI, 2.18 to 41.93; P = .03). Late feeding resulted in a significant decrease in number of patients with emesis (odds ratio 3.13; 95% CI, 2.26 to 4.35; P &lt; .00001).

LIMITATIONS:
Exclusion of non-English studies, lack of randomized controlled trials, insufficient number of studies to perform publication bias or subgroup analysis for potential predictors of emesis.

CONCLUSIONS:
Ad libitum feeding is recommended for patients after pyloromyotomy as it leads to decreased LOS. If physicians still prefer structured feeding, early rapid feeds are recommended as they should lead to a reduced LOS.
Cleft Lip Standardized Patient Examinations: The Role in Plastic Surgery Resident Education
Authors: Wright Eric J. , Khosla Rohit K. , Howell Lori , Luan Anna , Lee Gordon K. 
Published: December 2015

Background Our institution has incorporated the use of objective structured clinical examinations (OSCE) in our residency curriculum. The OSCE provides trainee education and evaluation while addressing the six Accreditation Council for Graduate Medical Education (ACGME) core competencies required within training programs. We report our program's experience with the first cleft OSCE ever conducted. Methods A validated method for administration of OSCEs currently used at our medical school was utilized for residents in postgraduate years (PGYs) 3 through 6. The video-recorded patient encounter involved a 1-month-old newborn with a unilateral cleft lip and palate and used standardized patient actors as parents. A post-encounter written exam assessed medical knowledge. A questionnaire regarding the utility of the exercise was administered to residents after the OSCE. Results were evaluated using analysis of variance ( P < .05). Results There was a positive correlation with increasing level of training in terms of medical knowledge ( P < .04). Residents in PGY-3 and PGY-4 demonstrated lower understanding of the surgical markings and details of the lip repair compared with those in PGY-5 and PGY-6 ( P < .03). All residents performed similarly on evaluation of the remaining ACGME core competencies. All residents agreed that this was a realistic and useful encounter. Conclusion Results of our cleft OSCE demonstrate that medical knowledge regarding the evaluation, management, and surgical repair of patients is less in midlevel residents. All residents expressed an interest in earlier exposure to pediatric patients in the training period. Although a cleft OSCE does not replace clinical rotations, it is a valuable adjunct to training and evaluation of trainees, particularly for junior residents.
Measuring Symmetry in Children with Cleft Lip. Part 2: Quantification of Nasolabial Symmetry before and after Cleft Lip Repair
Authors: Wu Jia , Liang Shu , Shapiro Linda , Tse Raymond 
Published: December 2015

Objective The first part of this study validated an automated computer-based method of identifying the three-dimensional midfacial plane in children with unrepaired cleft lip. The purpose of this second part is to develop computer-based methods to quantify symmetry and to determine the correlation of these measures to clinical expectations. Participants A total of 35 infants with unrepaired unilateral cleft lip and 14 infant controls. Interventions Six computer-based methods of quantifying symmetry were developed and applied to the three-dimensional images of infants with unilateral cleft lip before and after cleft lip repair and to those of controls. Main Outcome Measure Symmetry scores for cleft type, changes with surgery, and individual subjects ranked according to cleft severity were assessed. Results Significant differences in symmetry scores were found between cleft types and found before and after surgery. Symmetry scores for infants with unilateral cleft lip approached those of controls after surgery, and there was a strong correlation with ranked cleft severity. Conclusions Our computer-based three-dimensional analysis of nasolabial symmetry correlated with clinical expectations. Automated processing made measurement convenient. Use of these measures may help to objectively measure cleft severity and treatment outcome.
Histo-morphology of the alimentary canal in two freshwater snakehead fish Channa punctata and Channa striata
Authors: Borman Mita , Ara Ismot , Kamrujjaman Mohammad , Nabi Md Rafiqun 
Published: December 2015

The histo-morphological study of the alimentary canal of two carnivore freshwater snakehead fish Channa punctata and C. striata was carried out from October 2013 to July 2014. It revealed that three major parts like oesophagus, stomach and intestine composed of short thick-walled body. The oesophagus begins with buccopharynx. Structure and arrangement of both villiform and canine teeth on jaws in C. striata are more extendable and stronger than C. punctata and thereby made the former one more successful predator. The availability and arrangement pattern of mucous pits and taste bud pores in oesophagus are also prominent in C. striata. The TS of stomach of both the species has broad GM devoid of goblet mucous cells, but surface layer CC and basal layer GG open through gastric pits. The length of intestine (16.0 cm) and intestinal pyloric caeca (5.5 cm) in C. striata are larger than C. punctata (7.0 cm and 1.5 cm, respectively). However, the TS of intestinal Sr. 0.05 mm; MM. 0.8 mm; Mu 0.5 mm suggest in favour of carnivore habit of both the species.
ANÁLISE SÓCIO-PRODUTIVA DOS ASSENTAMENTOS EM CÁCERES, MATO GROSSO: POLÍTICAS PÚBLICAS PARA O DESENVOLVIMENTO TERRITORIAL
Authors: Miranda Scheuer Junior , Seabra Botti Nicoly , Alves da Silva Neves Sandra Mara 
Published: December 2015

<p class="Default"><span>O artigo tem como objetivo analisar o sistema sócio-produtivo da agricultura familiar nos assentamentos Bom Sucesso, Corixo, Jatobá, Katira, Nova Esperança, Rancho da Saudade e Sapiquá, localizados no município mato-grossense de Cáceres. A pesquisa foi realizada com 27 agricultores familiares e a coleta dos dados ocorreu no primeiro semestre de 2014 por meio de entrevista semiestruturada. A formação escolar dos agricultores familiares predominou-se em ensino fundamental incompleto, contraindo matrimônio e organizados em pequenas propriedades, utilizando mão de obra familiar nas atividades agropecuárias (policultura) em uma infraestrutura deficitária. Evidenciou-se a possibilidade de implementação das políticas públicas do Programa de Aquisição de Alimentos e do Programa Nacional de Alimentação Escolar devido à capacidade produtiva, a proximidade e existência de escolas e de comércio local. Para isso, os agricultores familiares precisam se organizar em associações/cooperativas e os poderes públicos intervir no espaço e promover ações sólidas de desenvolvimento territorial e da agricultura familiar.<strong></strong></span></p>
Outcomes of singleton and twin breech deliveries in a ten year (2005 to 2014) retrospective audit at two rural hospitals in Papua New Guinea’s Gulf Province
Authors: Carpenter Richard James , Mola Glen Liddell 
Published: December 2015

<p><span style="text-decoration: underline;">Introduction</span><em> </em>The aim of this audit was to investigate the rates of breech-related perinatal death and maternal and neo-natal morbidity in a resource-poor setting where caesarean sections are difficult to perform. <span style="text-decoration: underline;">Method</span><em>. </em>An audit of 5,102 babies born at two rural Papua New Guinean hospitals, Kapuna and Kikori, from 2005 to 2014 inclusive was performed. Information was gathered from the facility obstetric registers and supplemented by Kikori Hospital’s surgical register. During the period there were 179 breech presentations (103 singletons, 76 twins). The primary outcome was defined as perinatal death. Secondary outcomes were neonatal morbidity and maternal post-partum haemorrhage. Exclusion criteria were applied prior to analysis. These included: Likely pre-labour intrauterine death; mother presenting to hospital in second or third stage; baby born before arrival at hospital; prematurity recorded in the notes or birth weight less than 1500g as a surrogate marker; significant fetal abnormality; and significant maternal medical condition. <span style="text-decoration: underline;">Findings</span><em>. </em>The adjusted incidence of the outcomes were: Perinatal death for vaginal breech singletons 235/1,000 (95% CI 158-336/1,000) and vaginal breech twins 31/1,000 (95% CI 9-107/1,000); neonatal morbidity for vaginal breech singletons 141/1,000 (95% CI 82-231/1,000) and vaginal breech twins 31/1,000 (95% CI 9-107/1,000); post-partum haemorrhage for vaginal breech singletons 129/1,000 (95% CI 74-217/1,000) and vaginal breech twins 230/1,000 (95% CI 137-361/1,000). <span style="text-decoration: underline;">Conclusions</span><em>. </em>Poor outcomes for singleton vaginal breech delivery at the two hospitals were common. The potential in the rural setting for increased education on safe trial of vaginal breach delivery as well as increasing access to caesarean sections deserves consideration. </p>
The attention of the new public service in implementation of local autonomy bureaucracy in Indonesia
Authors: Datu T., T. 
Published: December 2015

<p>A principle of New Public Service in building performance is important in maintaining the efficiency, effectiveness and customer satisfaction. Paradigm of New Public Service as a public servant more prioritizes the interests of the public by improving the quality of service. Administrators who are responsible have to work to involve citizens in implementing programs to achieve general goals.</p><p>The economic crisis that hit Indonesia since 1997 until today shows that Indonesia does not have a solid foundation to be tough to face global changes. The Government has always had difficulty in reducing this nation to rise from adversity of economic, social, and politics. This misunderstanding increases uncertainty of economic, social, and politics, while the cost of providing government also increased.</p><p>Changes in Law No 5 in 1974 to Law No 32 in 2004 and Law No 25 in 1999 has not produced output that benefits society. In fact, there were impressed that the society is getting harder to obtain rights of public service. Moreover, if they are associated with the quality of government bureaucracy, the realization of local autonomy and rise of abuse of authority in government bureaucracy that estimated the systemic and even to the affected areas.</p><p> </p><p> Keywords: new public service, bureaucracy, local autonomy</p>
Introducing Form-Function Theory Evidence from the Post Position “ra” and Focus Marker “ke” in Persian
Authors: Oroji Mohammadreza , Rahbarian Shidak 
Published: December 2015

<p><strong> </strong></p><p>Traditionally in linguistics, there used to be trends to observe linguistic data from a definite angle; form or function. However, in modern linguistics, it has been fashionable to figure out a sort of interface between viewpoints such as syntax-pragmatic interface. There are elements in some languages which prompt the linguists to look upon them interactively and synchronously. Morphemes such as ‘ra’ and ‘ke’ in Persian necessitate an interactive scrutiny incorporating both formal and functional outlooks. Form-Function Theory introduced by Dabir-Moghaddam (2009) has facilitated the analysis of such elements. This article attempts to re-introduce this theory on the basis of evidence from Persian.</p><p> </p><p> Keywords: Form, function, form-function theory, interface, focus marker</p>
School-Community Partnership - an effective tool, useful for environmental community development of Romanian countryside
Authors: Băneș A. , Orboi M.D. , Popescu C. , Iancu T. 
Published: December 2015

<p>This paper presents the theoretical and practical implications of school - community partnership in community development of Romanian rural environment by conducting a content analysis of the addressed topic. In most Western countries, the trend of opening the school to the community is obvious. Because the resources for education are falling, the partnership can be an effective tool for better management of local resources, a way of attracting new resources for school, and harnessing the school resource in benefit of the community. Also, to ensure good quality education is necessary for every school to achieve a genuine partnership with its community. Under this partnership it is natural to find their place all social categories and all interested institutions in the development of education: human resources of the education system, students enrolled in schools, students families, government institutions and NGOs. In rural areas, the school is the most powerful institution, vital for community development. The school must be open to the needs of the rural community to identify those areas where it can develop community partnerships: alternative leisure activities for children and youth, activities of road education, health, helping the elderly and poor families, involvement in humanitarian campaigns, etc. The role of the school, parents and local authorities is very great, and the development of an active partnership between these participants in Romanian rural areas would reduce school dropout and integrate children with special educational needs. Schools that have developed genuine partnerships within the local school shows that the benefits are significant.</p><p> </p><p>Keywords: school-community partnership, dropout, integration, community development</p>