bluuebunny/crossref_metadata_2025_split huggingface dataset:
Knowledge, Attitude, and Practice among Practitioners Regarding Epilepsy in Bhutan: A Rural and a Remote Country
Authors: Bhalla Devender 
Published: November 2017

ABSTRACT
Purpose: Epilepsy is a major neurological disorder with many countries as scientifically silent and little-to-nothing known on various aspects of epilepsy. Methods: Taking background of a first multinational seminar on epilepsy in Bhutan and a short valid questionnaire pertaining to various aspects of epilepsy, before participation. Results: Large participation was achieved (76 out of 87 approached, 87.3%; 53.0% males). Based on the responses of 76.0% lecturers and clinician and medical administration, 21.0% nurses, and 3.0% traditional practitioners, important derivations were obtained: positively, (a) event provided at least an opportunity to bring service providers at a common platform toward initiating particular epilepsy goals, (b) none regarded epilepsy as contagious or due to past sins, (c) all responded favorably to that “they found this event useful' and 'this event added something meaningful to them personally or professionally,” (d) large participation indicated acceptance, need, and common interest among a number of stakeholders. Negatively, significant knowledge-deficit was noted: for 38.4% electroencephalogram is essential for diagnosis, 48.0% responded with incorrect definition of epilepsy, etc. Conclusions: Events, such as this, provides, for scientifically silent countries, basis for not only bringing service providers to a common platform but also to discuss to initiate particular epilepsy goals, to provide additional professional knowledge for strengthening service development, and to determine need and social acceptance around epilepsy. Important knowledge deficit was identified which cannot be fully explained through lack of time or limited training. There might be a need to reappraise the approach to teaching medical professionals about epilepsy.
Flow-diverting Stent-assisted Coil Embolization of a Ruptured Internal Carotid Artery Blister Aneurysm with the Pipeline Flex Embolization Device
Authors: Ding Dale , Starke Robert M. , Hope Ayton , Brew Stefan 
Published: November 2017

ABSTRACTInternal carotid artery (ICA) blister aneurysms are rare and challenging to successfully treat, using contemporary surgical or endovascular approaches, without partial or complete compromise of the parent vessel. We describe the use of a resheathable flow diverter, the Pipeline Flex Embolization Device (PFED) to perform stent-assisted coiling of a ruptured supraclinoid ICA blister aneurysm in a 56-year-old female who presented with a high-grade subarachnoid hemorrhage (SAH). The first PFED was deployed across the aneurysm neck to jail a microcatheter within the aneurysm dome, and then, two small coils were delivered into the aneurysm. After removing the coiling microcatheter, the second PFED was telescoped into the first PFED. There were no postprocedural complications, and follow-up magnetic resonance angiography 15 months after embolization showed complete aneurysm obliteration. Flow-diverting stent-assisted coiling should be considered as a reconstructive, vessel-preserving, endovascular treatment option for appropriately selected patients with ruptured ICA blister aneurysms. However, future studies are necessary to assess the periprocedural safety in the setting of acute SAH.
Use of Preoperative Ependymal Enhancement on Magnetic Resonance Imaging Brain as a Marker of Grade of Glioma
Authors: Sharma Sumit , Jain Shashi Kant , Sinha Virendra Deo 
Published: November 2017

ABSTRACT
Objectives: Neural stem cells within the subventricular zone (SVZ) are thought to be responsible for the origin and the heterogeneous nature of the gliomas. The relationship of the gliomas to the SVZ can be appreciated as ependymal enhancement on contrast magnetic resonance imaging (MRI). This study evaluates the rate of ependymal enhancement and its association with the histopathological grade of gliomas. Patients and Methods: Seventy-five patients with radiological features of glioma were recruited. Preoperative MRI was evaluated for the presence of ependymal enhancement and fluid-attenuated inversion recovery (FLAIR) signal proximity of tumor to ependyma, and the association to grade was investigated. Results: Seventy-five patients studied showed a male predominance (62.66%) with a mean age of 44.91 ± 13.64 years. Evidence of ependymal enhancement was positive in 24% (n =; 18), 46.67% (n =; 35) showed no evidence, and in 29.33% (n =; 22), assessment was inconclusive. According to WHO grading, 76% (n =; 57) were high-grade gliomas (HGGs) including Grade III (n =; 17) and Grade IV (n =; 40) and 24% (n =; 18) were low-grade gliomas (LGGs) Grade II. HGGs were significantly associated with ependymal enhancement (P< 0.01) and FLAIR signal proximity to the ependyma (P< 0.001). Among HGGs, rate of ependymal enhancement and FLAIR signal proximity was more in Grade IV than Grade III but was not statistically significant (P > 0.05). Conclusion: SVZ is associated with HGGs. These MRI features can be helpful in predicting the tumor grade preoperatively and by including LGGs, the role of SVZ in the heterogeneous disease process of glioma can be studied as a whole, not only in the glioblastoma (GBM).
The Knowledge and Attitudes of University Students concerning HPV Vaccine and Cervical Screening
Authors: Elit L , Trim K , Mohan R , Nastos S , Harnish D 
Published: November 2017

Background Cervical cancer is preventable with regular PAP tests and the human papillomavirus (HPV) vaccine. Objective Identify factors influencing initiation into regular sexual health examinations within a group of undergraduate health science students who have high parental SES. Methods After reviewing the literature, a survey of knowledge, attitudes and behaviors about HPV exposure and cervical cancer prevention through vaccination and cervical cancer screening was developed. The survey was circulated using a web-based survey tool to undergraduate Faculty of Health Sciences student. Results Two hundred and three students at McMaster University completed the survey. The sample included 72% women and 28% men. The mean age was 19.4 years. This sample represents a population of young adults who the previous literature would suggest are most likely to have regular health care since they are affluent (FAS greater than 6.7 ∓ 1.4). This group is also motivated in health education as 83.3% knew about the HPV vaccine and 76.4% could define the purpose of a PAP smear. Both male and female students were more likely to consult their family doctor about sexual health than their family. More than half of sexually active females have a family doctor, 82.1% of which visit them regularly. Sexually active women visit more regularly than sexually inactive women (p ≤ 0.01). The majority (66%) are comfortable discussing sexual health with their family doctor, yet only 62.5% of women have had this discussion. 57% of sexually active women and less that 1% of non-sexually active women had had a PAP smear or a pelvic exam. Conclusion These affluent and well educated students do not appear to be able to apply their knowledge of HPV and PAP smears to their own sexual health. Thus they require access to tools that help motivate university students to personalize information and make important health decisions.
Obesity and Time to Conception
Authors: Richman Susan 
Published: November 2017

Objective To examine the association between body mass index and time to conception. Methods Secondary data analysis of The Asthma in Pregnancy Study, a Prospective cohort of 2205 women assembled from April 1997-June 2000. Results Time to conception in women not on contraception, by BMI category, did not show a significant difference among the groups, p = 0.81 for test of equality over the strata. Conclusions No association between time to conception and BMI was demonstrated in these data.
Endometrial Thickness- a Practical Prospective Marker for the Risk of Surgical Intervention after RU486 Induced Abortion
Authors: Blumenfeld Zeev , Abdallah William , Kaplan Dalia , Nevo Ori 
Published: November 2017

Background Medical termination of pregnancy [TOP] during the early first trimester is commonly used. However, treatment failure which warrants surgical intervention occurs in small proportion of patients. Our objective was to examine the effectiveness and predictive value of sonographic measurement of endometrial thickness during a follow up visit after medical abortion as an accurate predictor of the necessity of curettage for completion of pregnancy termination. Methods Women who opted for medical TOP where treated by single dose of RU486 followed by a single dose of misoprostol. Endometrial thickness was evaluated by transvaginal U.S. at 14 days after misoprostol tretament. The data was collected prospectively for this cohort study which includes all the women undergoing medical abortion in the first seven weeks of gestation. Results In 34.7% of the patients the endometrial width was > 11 mm on the follow-up visit. Surgical intervention was performed in 18% of these patients, for a failure rate of the medical termination of pregnancy [TOP] of 6.25%, as compared with no failure rate in those with endometrium < 11 mm, P < 0.001. In the patients where the endometrium was 11-12 mm on follow-up, the failure rate was 5%, and if > 12 mm the failure was 5.9%. In cases where the endometrium was 12-13 mm the failure rate was 27.3%, and if >13 mm the failure was 18.9%. When the endometrium was 13-14 mm the failure rate was 10%, and when >14 mm the failure was 23.7%. Half of the 18 patients who had undergone dilatation and curettage [D&C] for completion of the TOP, had endometrium > 14 mm, one to two weeks after the medical abortion. Conclusion Measurement of endometrial width after medical TOP is beneficial in segregating patient to low or high risk for surgical treatment of retained product of conception [POC]. Using a cutoff of 11 mm during the follow-up visit after medical TOP, 18% of the patients may need dilatation and curettage to complete the pregnancy termination, and if it is >14 mm, half of them may need surgical intervention. There is no difference between 11 and 14 mm regarding the risk of surgical intervention after medical TOP.
P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)
Authors: Walts Ann E. , Lechago* Juan , Hu Bing , Shwayder MaryBeth , Sandweiss Lynn , Bose Shikha 
Published: November 2017

Background Significant variation is reported in the diagnosis of HPV-associated AIN. We previously observed that band-like positivity for p16 in >90% of contiguous cells coupled with Ki67 positivity in >50% of lesional cells is strongly associated with high grade AIN. This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variability in diagnosis and grading of AIN. Design H&E stained slides of 60 anal biopsies were reviewed by three pathologists and consensus diagnoses were achieved: 25 negative, 12 low (condyloma and/or AIN I) and 23 high (9 AIN II and 14 AIN III) grade lesions. The H&E stained slides were diagnosed independently by three additional (“participant”) pathologists. Several weeks later they re-examined these slides in conjunction with corresponding p16 and Ki67 immunostains. Results Addition of p16 and Ki67 immunostains reduced intra- and interobserver variability, improved concurrence with consensus diagnoses and reduced two-step differences in diagnosis. Negative and high grade AIN diagnoses showed the most improvement in concurrence levels. Conclusion Addition of p16 and Ki67 immunostains is helpful in the diagnosis and grading of AIN.
Histological Changes on Liver Glycogen Storage in Mice (Mus musculus) Caused by Unbalanced Diets
Authors: Ulusoy Esma , Eren Banu 
Published: November 2017

Weight-losing diets have appealed to people who want to lose weight in the short-term. They usually apply high-protein (HP) diets (like Atkin's, Stillman's, Scarsdale) which they practice for 2 weeks or so. Unfortunately, these people who have rapid weight loss return to their old habits and quickly regain the weight lost. We have shown in previous work that actually these weight losses have been associated with body fluids, protein and glycogen storage. In our study, we examined the effect of unbalanced diet–-related to an HP diet- on liver glycogen storage. For this study 40 Swiss albino mice consisting of two groups were used. The first group (HPSD) was fed with 25% HP for fifteen days and then were fed standard meals for the remaining 15 days; the other group was fed with standard meals throughout. The two groups were fed their respective diets for 30 days. At the end of 15th, 20th, 25th and 30th days 5 from each group were killed with cervical dislocation. The livers were removed perfused and then fixated. There were major differences in weight between the first and the fifteenth days. We detected remarkable increase in the weight gain of mice in the remaining 15 days. Glycogen storage was significantly reduced in HPSD (15) stained with PAS. In the others 20th, 25th and 30th days abnormally dense glycogen deposits were observed. Vacuoles in the hepatocyte cytoplasm, brownish deposits within hepatocytes, wide sinusoids, macrovesiculler steatosis structures and hydropic degeneration were observed in PAS and H&E stained HPSD group. As a result for the HPSD group a significant decrement in glycogen storage at the 15th day and also an accumulation of excessive amounts of glycogen deposits in mice liver was observed in the normal feeding phase.
Knowledge toward Cancer Pain and the Use of Opioid Analgesics among Medical Students in their Integrated Clinical Clerkship
Authors: Manalo Maria Fidelis C. 
Published: November 2017

Introduction Among the focal issues of barriers to pain management include the physicians’ lack of knowledge about cancer pain and negative attitudes towards opioids. Many physicians and educators attribute this, at least in part, to limited exposure to pain and palliative care education during medical school. Aim The researcher investigated the medical students’ knowledge about cancer pain and the use of opioid analgesics. Methods The subjects were a sample of 50 students of the University of the Philippines College of Medicine in their integrated clinical clerkship year. Descriptive statistics (frequencies, means, standard deviation, rating scales) were used to determine mean knowledge score and level of confidence with opioid use. The study also identified specific areas where students exhibited good or poor knowledge of opioids. Results Approximately sixty-nine (69%) of the study respondents mentioned that pain management was given to them during their Anesthesiology lectures while a few recalled that they had these lectures during their Family Medicine rotation in Supportive, Palliative and Hospice Care. More than a third (35%) of the respondents admitted to not being confident with morphine use at present. The top three reasons cited as limitations in choice of opioids for cancer pain include fear of addiction, lack of adequate knowledge and experience and fear of side effects and complications. Out of a maximum of 13 correct answers, the mean knowledge score of the medical students was 6.6 ± 2.9. Less than 16% of the respondents had adequate knowledge on cancer pain and opioid use. Conclusions The results show that basic knowledge of the role of opioids in cancer pain management among medical students in their integrated clinical clerkship year at the University of the Philippines is poor. The findings imply a need to look into making revisions in the medical curriculum to include a training program that will enable all students to graduate with basic competency in pain management and palliative care.
Dispositivo Robótico Multifuncional para la Rehabilitación de las Extremidades Superiores
Authors: Mancisidor Aitziber , Zubizarreta Asier , Cabanes Itziar , Bengoa Pablo , Hyung Jung Je 
Published: November 2017

<p>En este trabajo se presenta un dispositivo de rehabilitación innovador por su flexibilidad y eficiencia denominado Universal Haptic Pantograph (UHP). Este robot, gracias a su estructura multi-configurable permite la rehabilitación del miembro superior con un único dispositivo. Además, se ha diseñado con la habilidad de realizar diferentes tareas asistivas y resistivas, pudiendo así adaptarse al estado de recuperación del paciente. Finalmente, el software Telereha genera un entorno de realidad virtual que facilita la ejecución del ejercicio y aumenta la motivación del paciente. El sistema de control del robot se ha implementado entiempo real con el fin de garantizar la correcta ejecución de las tareas de rehabilitación. Usando este sistema, se han realizado diferentes ensayos experimentales. Los resultados demuestran que el robot de rehabilitación UHP funciona correctamente con diferentes tareas de rehabilitación, realizando movimientos suaves y seguros que garantizan la seguridad del usuario.</p>
Love at First Sight and an Arrangement for Life: Investigating and Interpreting a 1910 Hungarian Migrant Marriage
Authors: Oberly James W. 
Published: November 2017

Abstract
In May 1910, the New York Times published an article about an arranged marriage between two migrants from Austria-Hungary. “Hastens to Marry His Mother's Choice” was written as more than a charming story of love at first sight. Indeed, the reporter considered the love story an example of near instant assimilation of migrants into American culture. A deeper investigation of the life stories of the couple shows that they did understand some things about American life on the first day they met, namely, the need to falsely report the bride's age as 20 rather than 17. In other respects, the couple retained their ties to Central Europe, choosing to live and work in rural coal-mining villages dominated by migrants from Austria-Hungary. They experienced firsthand the good and bad of life as Americans: the high wages paid to migrant coal miners and the resulting higher standard of living than could be gained in Hungary, but also the violence of management-labor conflicts in the coal fields and the violence of the Ku Klux Klan against Roman Catholic migrants in the American Midwest. Over a lifetime, the couple changed their names from the Hungarian Mihály to “Mike” and from the Hungarian Piroska to “Pearl.” By the time of Piroska's death, her surviving children were so far removed from Hungarian life that they could not even spell their mother's maiden name.
La doble ruptura: problemas epistemológicos a partir de la construcción de una base de datos histórica relativa a la conversión forzada
Authors: Bueno Sánchez Marisa , Perreaux Nicolas 
Published: November 2017

Este articulo muestra algunos problemas epistemológicos derivados de la explotación de los textos recogidos en el proceso e creación de la base de datos del proyecto POCRAM, relativa a la cuestión de la «conversión religiosa» entre la antigüedad tardía y el fin de la edad moderna. Así mismo se hace un balance de la evolución de las humanidades numéricas (especialmente en Francia), así como de los proyectos precedentes en que se inspira la conceptualización de la base. Presentamos nuestro Corpus y las consecuencias de su explotación gracias al uso de diferentes software que provocan una doble ruptura, epistemológica y conceptual en la forma de entender la historia.
Distribution and abundance of muskoxen (Ovibos moschatus) and Peary caribou (Rangifer tarandus pearyi) on Graham, Buckingham, and southern Ellesmere islands, March 2015
Authors: Anderson Morgan , Kingsley Michael C.S. 
Published: November 2017

We flew a survey of southern Ellesmere Island, Graham Island, and Buckingham Island in March 2015 to obtain estimates of abundance for muskoxen and Peary caribou. Generally, muskoxen were abundant north of the Sydkap Ice Cap along Baumann Fiord, north of Goose Fiord, west and north of Muskox Fiord, and on the coastal plains and river valleys east of Vendom Fiord. Although few, they were also present on Bjorne Peninsula and the south coast between the Sydkap Ice Cap and Jakeman Glacier. We observed a total of 1146 muskoxen. Calves (approximately 10-months old) made up 22% of the observed animals. The population estimate was 3200 ± 602 SE (standard error) muskoxen, the highest muskox population size ever estimated for southern Ellesmere, Graham and Buckingham islands. This could be because previous efforts typically surveyed only a portion of our area or focused elsewhere, or the results were provided only as minimum counts rather than estimates of abundance. Regardless, our results indicate that the muskox population has recovered from low levels in 2005 of 312-670 (95% confidence interval [CI]) individuals. Peary caribou abundance appears to be low. We only saw 38 Peary caribou during our 2015 survey. This confounds appraisal of possible abundance change since 2005, when 109-442 caribou (95% CI) were estimated to inhabit the same surveyed area. We estimated 183 ± 128 SE Peary caribou, and suggest that their numbers are likely stable at low density on southern Ellesmere Island.
Temperature and dissolved oxygen stratification in the lake Rudrasagar: Preliminary investigations
Authors: Pal Mihir Pal , Samal Nihar R. , Roy Pankaj k. Roy , Roy Malabika B. 
Published: November 2017

Temperature drives the major physico-chemical and biological actions in inland water bodies. The higher the water temperature, the greater the biogeochemical activity influenced by the environmental intrinsic and extrinsic parameters. Temperature also controls the dynamics of sustainability of various aquatic organisms that live in lakes and reservoirs, though higher life forms, such as fish, insects, zooplankton, phytoplankton, and other aquatic species all have a recommended temperature variety. The increase in water temperature due to the increase in atmospheric air temperature results in lake water column stratification and the dissolved oxygen level variation in aquatic systems are greatly affected. The vertical distributions of dissolved oxygen in the water column are highly dependent due to change in vertical temperature gradient. In the present paper, an effort has been made to investigate the impact of temperature stratification on dissolved oxygen variability in the Rudrasagar, a natural lake in western Tripura. The changes in dissolved oxygen distribution in this natural lake will give us an idea of regional lake health condition and will also establish the need of further large scale research concerning the development of a biophysical-coupled model. Keywords: Thermal stratification, Dissolved Oxygen, Thermocline, Rudrasagar Lake, Hypolimnion