bluuebunny/crossref_metadata_2025_split huggingface dataset:
Techniques and long-term effects of transjugular intrahepatic portosystemic shunt on liver cirrhosis-related thrombotic total occlusion of main portal vein
Authors: Wang Lei , He Fuliang , Yue Zhendong , Zhao Hongwei , Fan Zhenhua , Zhao Mengfei , Qiu Bin , Yao Jiannan , Lin Qiushi , Dong Xiaoqun , Liu Fuquan 
Published: September 2017

AbstractPortal vein hypertension (PVH) in liver cirrhosis complicated with portal venous thrombosis (PVT) has been mainly treated with transjugular intrahepatic portosystemic shunt (TIPS). The clinical effects of TIPS have been confirmed, however, no large-scale studies have been focused on technical analyses and a long-term follow-up, especially on thrombotic total occlusion of main portal vein (MPV). To demonstrate critical techniques and clinical outcome of TIPS on liver cirrhosis-related thrombotic total occlusion of MPV, 98 patients diagnosed with liver cirrhosis related thrombotic total occlusion of MPV and treated with TIPS from January 2000 to January 2010 were retrospectively analyzed. Twenty-three (23.5%) patients had MPV (single site) thrombosis, 55 (56.1%) had multiple site-thrombosis (MPV and other), 17 (17.3%) had cavernous transformation of portal vein, and 3 (3.1%) had post-transplant thrombosis. The successful rate of TIPS was 90.7%, without any procedure-related deaths or severe complications. Mean portal pressure was dropped from 33.08 ± 1.38 mmHg preoperatively to 20.18 ± 0.83 mmHg postoperatively (p < 0.001). Collectively, TIPS is safe and effective in treating liver cirrhosis-related thrombotic total occlusion of MPV. This complex procedure requires combination of indirect portography and percutaneous transhepatic portal techniques to increase the rate of success.
Intraoperative Fentanyl Consumption Does Not Impact Cancer Recurrence or Overall Survival after Curative Colorectal Cancer Resection
Authors: Tai Ying-Hsuan , Wu Hsiang-Ling , Chang Wen-Kuei , Tsou Mei-Yung , Chen Hsiu-Hsi , Chang Kuang-Yi 
Published: September 2017

AbstractWhether opioid use in cancer surgery would promote tumor dissemination in humans is inconclusive. We investigated the effect of intraoperative fentanyl dose on colorectal cancer (CRC) prognosis following resection in this retrospective study. A total of 1679 patients with stage I-III CRC undergoing tumor resection between January 2011 and December 2014 were evaluated through August 2016. Postoperative recurrence-free survival (RFS) and overall survival (OS) were analyzed using Cox regression models. Multivariable Cox regression analysis demonstrated no dose-response association between the amount of fentanyl dose and RFS (adjusted hazard ratio: 1.03, 95% CI: 0.89–1.19) or OS (adjusted hazard ratio: 0.84, 95% CI: 0.64–1.09). Patients were further classified into the high- and low-dose groups by the median of fentanyl dose (3.0 μg·kg−1), and there was no significant difference in RFS or OS between groups, either (adjusted hazard ratio: 0.93, 95% CI: 0.74–1.17 for RFS; 0.79, 95% CI: 0.52–1.19 for OS). We concluded that intraoperative fentanyl consumption has no impact on recurrence-free or overall survival in patients after curative CRC resection.
An algorithm based on positive and negative links for community detection in signed networks
Authors: Su Yansen , Wang Bangju , Cheng Fan , Zhang Lei , Zhang Xingyi , Pan Linqiang 
Published: September 2017

AbstractCommunity detection problem in networks has received a great deal of attention during the past decade. Most of community detection algorithms took into account only positive links, but they are not suitable for signed networks. In our work, we propose an algorithm based on random walks for community detection in signed networks. Firstly, the local maximum degree node which has a larger degree compared with its neighbors is identified, and the initial communities are detected based on local maximum degree nodes. Then, we calculate a probability for the node to be attracted into a community by positive links based on random walks, as well as a probability for the node to be away from the community on the basis of negative links. If the former probability is larger than the latter, then it is added into a community; otherwise, the node could not be added into any current communities, and a new initial community may be identified. Finally, we use the community optimization method to merge similar communities. The proposed algorithm makes full use of both positive and negative links to enhance its performance. Experimental results on both synthetic and real-world signed networks demonstrate the effectiveness of the proposed algorithm.
Lateral movements of a massive tail influence gecko locomotion: an integrative study comparing tail restriction and autotomy
Authors: Jagnandan Kevin , Higham Timothy E. 
Published: September 2017

AbstractTails are an intricate component of the locomotor system for many vertebrates. Leopard geckos (Eublepharis macularius) possess a large tail that is laterally undulated during steady locomotion. However, the tail is readily shed via autotomy, resulting in the loss of tail function, loss in body mass, and a cranial shift in the center of mass. To elucidate the function of tail undulations, we investigated changes in limb kinematics after manipulating the tail artificially by restricting tail undulations and naturally by removing the tail via autotomy. Restricting tail undulations resulted in kinematic adjustments similar to those that occur following tail autotomy, characterized by more flexed hind limb joints. These data suggest that effects of autotomy on locomotion may be linked to the loss of tail movements rather than the loss of mass or a shift in center of mass. We also provide empirical support for the link between lateral tail undulations and step length through the rotation of the pelvic girdle and retraction of the femur. Restriction and autotomy of the tail limits pelvic rotation, which reduces femur retraction and decreases step length. Our findings demonstrate a functional role for tail undulations in geckos, which likely applies to other terrestrial vertebrates.
Spontaneous approaches of divers by free-ranging orcas (Orcinus orca): age- and sex-differences in exploratory behaviours and visual laterality
Authors: Chanvallon Stéphanie , Blois-Heulin Catherine , Robert de Latour Pierre , Lemasson Alban 
Published: September 2017

AbstractRunning comparative studies of laterality in mammals is a way to deepen our understanding of the evolution of the brain hemisphere functions. Studies on vision highlighted a possible task-sharing between hemispheres depending on the characteristics of the observers, the nature of the observed stimulus and the context of the observation, a phenomenon that could go beyond the monitoring of conspecifics. Cetaceans are predators that adapted to an aquatic habitat and display a clear crossing of fibers to the side of the brain opposite the eye of origin. Here, we analysed the interactions between humans and cetaceans when free-ranging orcas approach divers. Our study concentrated on the spontaneous exploratory behaviours of divers by orcas depending on their age and sex, and on the possible expression of a visual laterality. The results showed a significant preference for the use of the left eye but exclusively in adult females. Adult males had a more sustained attention than adult females, marked by a higher spatial proximity to divers, slower approaches and longer look durations. Adult females, probably more cautious, explored from the distance and more furtively. Our findings support a possible link between attentional/motivational states and visual laterality in mammals.
Photothermal enhancement of chemotherapy in breast cancer by visible irradiation of Gold Nanoparticles
Authors: Mendes Rita , Pedrosa Pedro , Lima João C. , Fernandes Alexandra R. , Baptista Pedro V. 
Published: September 2017

AbstractPhotothermal Therapy (PTT) impact in cancer therapy has been increasing due to the enhanced photothermal capabilities of a new generation of nanoscale photothermal agents. Among these nanoscale agents, gold nanoshells and nanorods have demonstrated optimal properties for translation of near infra-red radiation into heat at the site of interest. However, smaller spherical gold nanoparticles (AuNPs) are easier to produce, less toxic and show improved photoconversion capability that may profit from the irradiation in the visible via standard surgical green lasers. Here we show the efficient light-to-heat conversion of spherical 14 nm AuNPs irradiated in the visible region (at the surface plasmons resonance peak) and its application to selectively obliterate cancer cells. Using breast cancer as model, we show a synergistic interaction between heat (photoconversion at 530 nm) and cytotoxic action by doxorubicin with clear advantages to those of the individual therapy approaches.
In vitro exposure of simulated meat-cooking fumes to assess adverse biological effects
Authors: Poudel Bijay Kumar , Choi Jungwook , Park Jae Hong , Doh Kyung-Oh , Byeon Jeong Hoon 
Published: September 2017

AbstractThe heterocyclic amine 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is considered as a human carcinogenic or mutagenic compound that is produced from the co-condensation of creatinine and amino acids as meats cook at high temperatures. The cooking of meats at high temperatures produces fumes, and these fumes can be suspended as aerosols via the vapor-to-particle (or -droplet) process in a temperature gradient field. Size distributions of the aerosols included a significant portion of nano- and submicron-sized particles, and these can be directly deposited in the lungs and on skin by particle transport phenomena near cooking areas. In this study, for the first time, PhIP-incorporated oleic acid (OA, simulating cooking oil) (PhIP@OA) particles, including individual particulate PhIP as simulated fumes from meat cooking, were constantly produced via collison atomization and subsequent drying processes. The aerosol particles were then dispersed in phosphate-buffered saline for cytotoxicity and senescence-associated β-galactosidase assays, which were compared with dissolved PhIP in dimethyl sulfoxide. PhIP and PhIP@OA did not show significant cytotoxic effects on SHSY5Y, MRC5, and human dermal fibroblast cells compared with the dissolved PhIP but clearly induced premature senescence activities that may be caused by a limited release of PhIP molecules from the particulate PhIP.
High-pressure zinc oxide phase as visible-light-active photocatalyst with narrow band gap
Authors: Razavi-Khosroshahi Hadi , Edalati Kaveh , Wu Ji , Nakashima Yuki , Arita Makoto , Ikoma Yoshifumi , Sadakiyo Masaaki , Inagaki Yuji , Staykov Aleksandar , Yamauchi Miho , Horita Zenji , Fuji Masayoshi 
Published: September 2017

High-pressure rocksalt ZnO with a band gap of 1.8 eV, which can absorb visible light.
White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 2: Liver and Other Applications in Oncology
Authors: Barkhausen Jörg , Kahn Thomas , Krombach Gabriele , Kuhl Christiane , Lotz Joachim , Maintz David , Ricke Jens , Schönberg Stefan , Vogl Thomas , Wacker Frank ,   German Association of Chairmen in Academic Radiology (KLR)
Published: September 2017

Background MRI is attractive for guiding and monitoring interventional procedures due to its high intrinsic soft tissue contrast and the possibility to measure flow and cardiac function.
Methods Technical solutions have been developed for all procedural steps including imaging guidance, MR-safe catheters and instruments and patient monitoring. This has led to widening of the clinical applications. Interventional MRI is becoming increasingly important for the treatment of patients suffering from malignant diseases. The detectability of masses and consequently their accessibility for biopsy is higher, compared to other modalities, due to the high intrinsic soft tissue contrast of MRI. Temperature-dependent sequences allow for minimally invasive and tissue-sparing ablation (A-0 ablation).
Conclusion Interventional MRI has become established in the clinical routine for a variety of indications, including biopsies and tumor ablation. Since the economic requirement of covering costs by reimbursement is met and interventional MRI decreases the mortality and morbidity of interventional procedures, broader application of interventional MRI can be expected in the clinical routine in the future.
Key points
Citation Format
Discourse analysis as critique
Authors: Nonhoff Martin 
Published: September 2017

AbstractThis paper intervenes in the discussion about the relationship between discourse analysis and critique. It argues that this relationship can be understood either as an external or as an integrated relationship. In an external relationship, there is first social criticism that is then braced by discourse analysis, that is, the latter aims at giving empirical credence to the critique. However, such an external relationship cannot give us any insight concerning the critical potential that isspecificto discourse analysis, precisely because in this case critique exists before and independent of discourse analysis. If, however, critique emanates from discourse analysis itself, we would speak of an integrated relationship and would no longer speak of discourse analysis and critique, but of discourse analysisascritique. It is argued that such an integrated relationship becomes visible once we think of discourse analysis as being itself a discursive formation and ask what unsettling effects this formation has on research objects, on subject formations and on the academic production context in which they are conducted.
Transformation, adaptation and development: relating concepts to practice
Authors: Few Roger , Morchain Daniel , Spear Dian , Mensah Adelina , Bendapudi Ramkumar 
Published: September 2017

AbstractIn recent years there has been a growing number of academic reviews discussing the theme of transformation and its association with adaptation to climate change. On the one hand this has stimulated exchange of ideas and perspectives on the parameters of transformation, but it has also given rise to confusion in terms of identifying what constitutes a non-incremental form of adaptation on the ground. What this article aims to do instead is help researchers and practitioners relate different interpretations of transformation to practice by proposing a typological framework for categorising forms of change that focuses on mechanisms and objectives. It then discusses how these categorisations link to the broader conceptions and critiques noted above, with the idea that this will enable those who seek to analyse or plan adaptation to better analyse what types of action are potentially constitutive of transformation. In doing so, it should equally assist in the identification and specification of critical questions that need to be asked of such activity in relation to issues of sustainability and equity.
The Asian Infrastructure Investment Bank's environmental and social policies: a critical discourse analysis
Authors: Radavoi Ciprian N. , Bian Yongmin 
Published: September 2017

AbstractLike all other multilateral development banks, the Asian Infrastructure Investment Bank (AIIB), which approved its first loan in November 2016, has adopted Environmental, Social and Governance (ESG) policies. Treating the text as Chinese discourse and using Critical Discourse Analysis as methodological tool, this article unveils socio-political interests beyond its contents and semiotics. We identify areas where the AIIB policies are intertextual with the ones that inspired them, namely those of the World Bank and the regional multilateral development banks, but also important departures from their discursive practice, reflecting the legal culture and strategic interests of AIIB's founders. Both appropriation and colonisation of ‘classical’ ESGs by the AIIB ones lead to reflection on social wrongs associated with development, and suggest solutions for turning development safeguards into meaningful instruments.
Price Signals and Supply Responses for Staple Food Crops in Sub‐Saharan Africa
Authors: Magrini Emiliano , Balié Jean , Morales‐Opazo Cristian 
Published: September 2017

AbstractWe investigate the supply response for main staple food crops in Sub‐Saharan Africa over the period 2005−2013 using an innovative dataset recently developed by FAO’s “Monitoring and Analysing Food and Agricultural Policies” (MAFAP) programme. Relying on dynamic panel techniques, we observe that acreage, production and yields respond to price signals, even if with a limited intensity. Moreover, we find that direct price incentives arising from border protection, government interventions in domestic markets, and price shocks at the border stimulate farmers’ supply. We also show that omitting transaction costs from the analysis leads to underestimation of the price elasticity of supply. Conversely, using wholesale instead of farm gate prices as proxy for producer prices leads to overestimation of this price elasticity.
Three-dimensional cardiovascular imaging-genetics: a mass univariate framework
Authors: Biffi Carlo , de Marvao Antonio , Attard Mark I , Dawes Timothy J W , Whiffin Nicola , Bai Wenjia , Shi Wenzhe , Francis Catherine , Meyer Hannah , Buchan Rachel , Cook Stuart A , Rueckert Daniel , O’Regan Declan P 
Published: September 2017

AbstractMotivationLeft ventricular (LV) hypertrophy is a strong predictor of cardiovascular outcomes, but its genetic regulation remains largely unexplained. Conventional phenotyping relies on manual calculation of LV mass and wall thickness, but advanced cardiac image analysis presents an opportunity for high-throughput mapping of genotype-phenotype associations in three dimensions (3D).ResultsHigh-resolution cardiac magnetic resonance images were automatically segmented in 1124 healthy volunteers to create a 3D shape model of the heart. Mass univariate regression was used to plot a 3D effect-size map for the association between wall thickness and a set of predictors at each vertex in the mesh. The vertices where a significant effect exists were determined by applying threshold-free cluster enhancement to boost areas of signal with spatial contiguity. Experiments on simulated phenotypic signals and SNP replication show that this approach offers a substantial gain in statistical power for cardiac genotype-phenotype associations while providing good control of the false discovery rate. This framework models the effects of genetic variation throughout the heart and can be automatically applied to large population cohorts.Availability and implementationThe proposed approach has been coded in an R package freely available at https://doi.org/10.5281/zenodo.834610 together with the clinical data used in this work.Supplementary informationSupplementary data are available at Bioinformatics online.
Life Course Patterns of Concurrent Trajectories of BMI and Affective Symptoms of Rural Mothers: Socioeconomic Antecedents and Disease Outcomes in Later Life
Authors: Wickrama Kandauda (K A S) , Klopack Eric T , O’Neal Catherine Walker , Beach Steven R H , Neppl Tricia , Lorenz Frederick O , Bae Dayoung 
Published: September 2017

Abstract

Objectives
The current study, using prospective data over 25 years (1991–2015), concurrently investigates patterns of body mass index (BMI) and affective symptom trajectories in middle-aged mothers and the socioeconomic antecedents and disease outcomes of these patterns.

Method
Growth mixture modeling was used to identify latent classes of conjoint health risk trajectories (BMI, depressive symptoms, and anxiety symptoms) from 1991 to 2001. For each latent class, we identified mean trajectories of each health risk. Then, analyses were conducted identifying how these conjoint health risk classes were associated with respondents’ socioeconomic background profiles in 1991 and subsequent chronic health problems in 2015.

Results
Socioeconomic background profiles were significantly associated with initially high-risk trajectories. There was a statistically significant association between membership in certain classes of conjoint trajectories and physical health outcomes in later years. Consistent patterns of association with changes in different health outcomes including onset of diseases were observed when classes of conjoint risk trajectories are examined.

Discussion
The identification of members of various conjoint risk trajectory groups provides a potentially useful prognostic tool for early preventive intervention efforts, treatment, and policy formation. Such interventions should promote and develop resiliency factors, thereby aiding in the redirection of middle-aged women’s adverse risk trajectories.
Matrix Inequality for the Laplace Equation
Authors: Park Jiewon 
Published: September 2017

Abstract
Since Li and Yau obtained the gradient estimate for the heat equation, related estimates have been extensively studied. With additional curvature assumptions, matrix estimates that generalize such estimates have been discovered for various time-dependent settings, including the heat equation on a Kähler manifold, Ricci flow, Kähler–Ricci flow, and mean curvature flow, to name a few. As an elliptic analogue, Colding proved a sharp gradient estimate for the Green function on a manifold with nonnegative Ricci curvature. In this article, we prove a related matrix inequality on manifolds with suitable curvature and volume growth assumptions.
Weighted density fields as improved probes of modified gravity models
Authors: Llinares Claudio , McCullagh Nuala 
Published: September 2017

Abstract
When it comes to searches for extensions to general relativity, large efforts are being dedicated to accurate predictions for the power spectrum of density perturbations. While this observable is known to be sensitive to the gravitational theory, its efficiency as a diagnostic for gravity is significantly reduced when Solar system constraints are strictly adhered to. We show that this problem can be overcome by studying weighted density fields. We propose a transformation of the density field for which the impact of modified gravity on the power spectrum can be increased by more than a factor of three. The signal is not only amplified, but the modified gravity features are shifted to larger scales that are less affected by baryonic physics. Furthermore, the overall signal-to-noise ratio increases, which in principle makes identifying signatures of modified gravity with future galaxy surveys more feasible. While our analysis is focused on modified gravity, the technique can be applied to other problems in cosmology, such as the detection of neutrinos, the effects of baryons or baryon acoustic oscillations.