bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid-deployment or transcatheter aortic valves in intermediate-risk patients?
Authors: Bruno Piergiorgio , Di Cesare Alessandro , Nesta Marialisa , Cammertoni Federico , Mazza Andrea , Paraggio Lazzaro , Rosenhek Raphael , Burzotta Francesco , Crea Filippo , Trani Carlo , Massetti Massimo 
Published: March 2017

Background Transcatheter aortic valve implantation and rapid-deployment aortic valve replacement represent two emerging therapies for patients with intermediate surgical risk and severe aortic stenosis. However, head-to-head comparisons between such novel therapies are lacking. Methods Severe aortic stenosis patients with intermediate surgical risk treated with rapid-deployment valve replacement at our institution were identified and compared with a propensity-matched population of patients who underwent transcatheter aortic valve replacement. Postoperative echocardiographic findings, in-hospital and midterm clinical outcomes were compared. Results We identified 60 patients who received transcatheter ( n = 30) or rapid-deployment ( n = 30) valve replacement. On postoperative echocardiography, freedom from paravalvular regurgitation was higher in the rapid-deployment valve group ( p < 0.001), while postoperative mean transprosthetic gradient was lower in the transcatheter valve group ( p = 0.03). Permanent pacemaker implantation was required more frequently in transcatheter valve patients ( p = 0.01). Postoperative atrial fibrillation was more common in the rapid-deployment valve group ( p = 0.03). Hospital mortality was similarly low in both groups ( p = 0.33). At midterm follow-up, mortality was comparable ( p = 0.42) but the rapid-deployment valve group still had a lower degree of paravalvular regurgitation. Conclusions Transcatheter and rapid-deployment valve replacement are promising treatment options for patients with intermediate surgical risk. These two techniques are associated with specific patterns of prosthesis function and postoperative complications. Further evaluation of the clinical impact of these therapies in this patient population is needed.
Emergency Food Assistance in Northern Syria: An Evaluation of Transfer Programs in Idleb Governorate
Authors: Doocy Shannon , Tappis Hannah , Lyles Emily , Witiw Joseph , Aken Vicki 
Published: March 2017

Background: The war in Syria has left millions struggling to survive amidst violent conflict, pervasive unemployment, and food insecurity. Although international assistance funding is also at an all-time high, it is insufficient to meet the needs of conflict-affected populations, and there is increasing pressure on humanitarian stakeholders to find more efficient, effective ways to provide assistance. Objective: To evaluate 3 different assistance programs (in-kind food commodities, food vouchers, and unrestricted vouchers) in Idleb Governorate of Syria from December 2014 and March 2015. Methods: The evaluation used repeated survey data from beneficiary households to determine whether assistance was successful in maintaining food security at the household level. Shopkeeper surveys and program monitoring data were used to assess the impact on markets at the district/governorate levels and compare the cost-efficiency and cost-effectiveness of transfer modalities. Results: Both in-kind food assistance and voucher programs showed positive effects on household food security and economic measures in Idleb; however, no intervention was successful in improving all outcomes measured. Food transfers were more likely to improve food access and food security than vouchers and unrestricted vouchers. Voucher programs were found to be more cost-efficient than in-kind food assistance, and more cost-effective for increasing household food consumption. Conclusion: Continuation of multiple types of transfer programs, including both in-kind assistance and vouchers, will allow humanitarian actors to remain responsive to evolving access and security considerations, local needs, and market dynamics.
Acute basilar artery occlusion: Endovascular Interventions versus Standard Medical Treatment (BEST) Trial—Design and protocol for a randomized, controlled, multicenter study
Authors: Liu Xinfeng , Xu Gelin , Liu Yuxiu , Zhu Wusheng , Ma Minmin , Xiong Yunyun , Zi Wenjie , Dai Qiliang , Leung Thomas , Yan Bernard , Davis Stephen , Liebeskind David S , Pereira Vítor M , Nogueira Raul G 
Published: March 2017

Rationale Endovascular treatment plus standard medical therapy is superior to standard medical therapy alone for acute anterior proximal intracranial large artery occlusion strokes. The benefit of endovascular treatment in acute ischemic stroke caused by basilar artery occlusion remains unproven. Aim This study compares the safety and efficacy of endovascular treatment plus standard medical therapy versus standard medical therapy alone in acute ischemic stroke due to basilar artery occlusion. Design The study is a multicenter randomized control trial with blinded outcome assessment. A projected total 344 subjects with acute basilar arterial occlusion within 8 h of estimated occlusion time will be enrolled over three years in China. Patients will be assigned to endovascular treatment plus standard medical therapy and standard medical therapy alone group in 1:1 ratio for study centers. Study outcomes The primary outcome measure is a favorable functional outcome, defined as a modified Rankin Score of 0–3 at 90 days. The primary safety measure is mortality at 90 days. Trial registration ClinicalTrials.gov (NCT 02441556). Summary The BEST trial will provide valuable insights into the safety and efficacy of endovascular treatment for acute ischemic stroke patients with basilar artery occlusion.
Unclear-onset intracerebral hemorrhage: Clinical characteristics, hematoma features, and outcomes
Authors: Inoue Yasuteru , Miyashita Fumio , Koga Masatoshi , Minematsu Kazuo , Toyoda Kazunori 
Published: March 2017

Background and purpose Although unclear-onset ischemic stroke, including wake-up ischemic stroke, is drawing attention as a potential target for reperfusion therapy, acute unclear-onset intracerebral hemorrhage has been understudied. Clinical characteristics, hematoma features, and outcomes of patients who developed intracerebral hemorrhage during sleep or those with intracerebral hemorrhage who were unconscious when witnessed were determined. Methods Consecutive intracerebral hemorrhage patients admitted within 24 hours after onset or last-known normal time were classified into clear-onset intracerebral hemorrhage and unclear-onset intracerebral hemorrhage groups. Outcomes included initial hematoma volume, initial National Institutes of Health Stroke Scale score, hematoma growth on 24-hour follow-up computed tomography, and vital and functional prognoses at 30 days. Results Of 377 studied patients (122 women, 69 ± 11 years old), 147 (39.0%) had unclear-onset intracerebral hemorrhage. Patients with unclear-onset intracerebral hemorrhage had larger hematoma volumes (p = 0.044) and higher National Institutes of Health Stroke Scale scores (p < 0.001) than those with clear-onset intracerebral hemorrhage after multivariable adjustment for risk factors and comorbidities. Hematoma growth was similarly common between the two groups (p = 0.176). There were fewer patients with modified Rankin Scale (mRS) scores of 0–2 (p = 0.033) and more patients with mRS scores of 5–6 (p = 0.009) and with fatal outcomes (p = 0.049) in unclear-onset intracerebral hemorrhage group compared with clear-onset intracerebral hemorrhage as crude values, but not after adjustment. Conclusions Patients with unclear-onset intracerebral hemorrhage presented with larger hematomas and higher National Institutes of Health Stroke Scale scores at emergent visits than those with clear-onset intracerebral hemorrhage, independent of underlying characteristics. Unclear-onset intracerebral hemorrhage patients showed poorer 30-day vital and functional outcomes than clear-onset intracerebral hemorrhage patients; these differences seem to be mainly due to initial hematoma volumes and National Institutes of Health Stroke Scale scores.
Neuroleptic malignant syndrome following catatonia: Vigilance is the price of antipsychotic prescription
Authors: Reilly Thomas J , Cross Sean , Taylor David M , Haslam Richard , Tomlin Sophie C , Gaastra Benjamin 
Published: March 2017

Objectives: To describe a case of neuroleptic malignant syndrome following antipsychotic treatment of catatonia, highlighting the potentially serious complications of this rare adverse drug reaction. Methods: We present a case report of a patient who developed this syndrome with various sequelae. Results: The patient developed neuroleptic after being treated with lorazepam and olanzapine for catatonia. He subsequently developed the complications of rhabdomyolysis, acute kidney injury, pulmonary embolism, urinary retention and ileus. He received high-dose lorazepam, anticoagulation and intravenous fluids. Antipsychotic medication in the form of haloperidol was reinstated with no adverse effect, and he went on to make a full recovery. Conclusions: This case illustrates the potential life-threatening complications of neuroleptic malignant syndrome and the need for a low index of clinical suspicion. It also highlights the lack of evidence for treatment of catatonia, including the use of antipsychotics.
Anatomic and Biomechanical Comparison of the Classic and Congruent-Arc Techniques of the Latarjet Procedure
Authors: Montgomery Scott R. , Katthagen Jan Christoph , Mikula Jacob D. , Marchetti Daniel C. , Tahal Dimitri S. , Dornan Grant , Dahl Kimi , Brady Alex , Turnbull Travis L. , Millett Peter J. 
Published: March 2017

Objectives: The Latarjet procedure is commonly performed using either the classic (standing) or the congruent-arc (lying) technique. There are potential clinical advantages and disadvantages of each technique. However, the anatomic and biomechanical effects, benefits, and limitations of each technique are unknown. The purpose of this study was to compare the anatomy and biomechanical strength of fixation between the two techniques. Methods: A biomechanical cadaver study was performed with 20 pairs of male and female shoulders (n=40). One of each pair of shoulders was randomly assigned to receive the classic or congruent-arc technique. Coracoid and glenoid anatomic measurements were collected prior to biomechanical testing. A pull force was applied through the conjoined tendon to replicate forces experienced by the coracoid graft in the early post-operative period, and the failure load was determined for each specimen ( Figure 1 ). [Figure: see text] Results: The mean surface area available for fixation in the classic technique was 263.3 mm2 compared to 177.0 mm2 in the congruent-arc group (p<0.001). In the classic group, 36% of the glenoid width was re-created, and 50% was re-created in the congruent-arc group (p<0.001). The congruent-arc technique resulted in a significantly lower (p=0.005) mean failure load (238.9 ± 91.2 N) compared to the classic technique (303.0 ± 114 N). Failure load was significantly higher in males (p=0.037); male specimens had a mean failure load of 343.9 ± 122.2 N for the classic technique and 289.4 ± 73.0 N for the congruent-arc technique, and females had a mean failure load of 266.1 ± 97.7 and 193.5 ± 84.0 N, respectively ( Figure 2 ). [Figure: see text] Conclusion: In this biomechanical model, the classic technique of the Latarjet procedure provided a greater surface area for healing to the glenoid and greater biomechanical strength of fixation when compared to the congruent-arc technique. The congruent-arc technique allowed restoration of a larger glenoid defect.
Prevention of periprosthetic joint infection
Authors: Parvizi J. , Shohat N. , Gehrke T. 
Published: March 2017

The World Health Organization (WHO) and the Centre for Disease Control and Prevention (CDC) recently published guidelines for the prevention of surgical site infection. The WHO guidelines, if implemented worldwide, could have an immense impact on our practices and those of the CDC have implications for healthcare policy in the United States. Our aim was to review the strategies for prevention of periprosthetic joint infection in light of these and other recent guidelines. Cite this article: Bone Joint J 2017;99-B(4 Supple B):3–10.
Posterior condylar offset is an independent predictor of functional outcome after revision total knee arthroplasty
Authors: Clement N. D. , MacDonald D. J. , Hamilton D. F. , Burnett R. 
Published: March 2017

ObjectivesPreservation of posterior condylar offset (PCO) has been shown to correlate with improved functional results after primary total knee arthroplasty (TKA). Whether this is also the case for revision TKA, remains unknown. The aim of this study was to assess the independent effect of PCO on early functional outcome after revision TKA.MethodsA total of 107 consecutive aseptic revision TKAs were performed by a single surgeon during an eight-year period. The mean age was 69.4 years (39 to 85) and there were 59 female patients and 48 male patients. The Oxford Knee Score (OKS) and Short-form (SF)-12 score were assessed pre-operatively and one year post-operatively. Patient satisfaction was also assessed at one year. Joint line and PCO were assessed radiographically at one year.ResultsThere was a significant improvement in the OKS (10.6 points, 95% confidence interval (CI) 8.8 to 12.3) and the SF-12 physical component score (5.9, 95% CI 4.1 to 7.8). PCO directly correlated with change in OKS (p < 0.001). Linear regression analysis confirmed the independent effect of PCO on the OKS (p < 0.001) and the SF-12 physical score (p = 0.02). The overall rate of satisfaction was 85% and on logistic regression analysis improvement in the OKS (p = 0.002) was a significant predictor of patient satisfaction, which is related to PCO; although this was not independently associated with satisfaction.ConclusionPreservation of PCO should be a major consideration when undertaking revision TKA. The option of increasing PCO to balance the flexion gap while maintaining the joint line should be assessed intra-operatively. Cite this article: N. D. Clement, D. J. MacDonald, D. F. Hamilton, R. Burnett. Posterior condylar offset is an independent predictor of functional outcome after revision total knee arthroplasty. Bone Joint Res 2017;6:172–178. DOI: 10.1302/2046-3758.63.BJR-2015-0021.R1.
Silencing of translation initiation factor eIF3b promotes apoptosis in osteosarcoma cells
Authors: Choi Y. J. , Lee Y. S. , Lee H. W. , Shim D. M. , Seo S. W. 
Published: March 2017

Objectives Eukaryotic translation initiation factor 3 (eIF3) is a multi-subunit complex that plays a critical role in translation initiation. Expression levels of eIF3 subunits are elevated or decreased in various cancers, suggesting a role for eIF3 in tumorigenesis. Recent studies have shown that the expression of the eIF3b subunit is elevated in bladder and prostate cancer, and eIF3b silencing inhibited glioblastoma growth and induced cellular apoptosis. In this study, we investigated the role of eIF3b in the survival of osteosarcoma cells. Methods To investigate the effect of eIF3b on cell viability and apoptosis in osteosarcoma cells, we first examined the silencing effect of eIF3b in U2OS cells. Cell viability and apoptosis were examined by the Cell Counting Kit-8 (CCK-8) assay and Western blot, respectively. We also performed gene profiling to identify genes affected by eIF3b silencing. Finally, the effect of eIF3b on cell viability and apoptosis was confirmed in multiple osteosarcoma cell lines. Results eIF3b silencing decreased cell viability and induced apoptosis in U2OS cells, and by using gene profiling we discovered that eIF3b silencing also resulted in the upregulation of tumour necrosis factor receptor superfamily member 21 (TNFRSF21). We found that TNFRSF21 overexpression induced cell death in U2OS cells, and we confirmed that eIF3b silencing completely suppressed cell growth in multiple osteosarcoma cell lines. However, eIF3b silencing failed to suppress cell growth completely in normal fibroblast cells. Conclusion Our data led us to conclude that eIF3b may be required for osteosarcoma cell proliferation by regulating TNFRSF21 expression. Cite this article: Y. J. Choi, Y. S. Lee, H. W. Lee, D. M. Shim, S. W. Seo. Silencing of translation initiation factor eIF3b promotes apoptosis in osteosarcoma cells. Bone Joint Res 2017;6:186–193. DOI: 10.1302/2046-3758.63.BJR-2016-0151.R2.
Occurrence of dental involvement in victims of violence
Authors: Barbieri Ana Amélia , França Cristiano de , Naressi Suely Carvalho Mutti , Tosello Darcy de Oliveira , Daruge Júnior Eduardo 
Published: March 2017

Objective - To verify the occurrence of dental involvement described in medical examination reports on facial trauma resulting from interpersonal violence. Material and methods: an observational, analytical, and retrospective study that verified the dental involvement described in all the medical examination reports involving facial trauma, arising from interpersonal violence, issued by the Instituto Médico Legal - IML (Forensic Medicine Institute) of Taubaté, in São Paulo state, in a period of 24 months, considering gender and age group. Results: Of the 12,184 reports issued during the period studied, 1,971 (16.17%) described facial injuries resulting from aggression, and of these, 5.07% contained reports of dental involvement. The most frequent injury was a fracture (2.99%), in the age range between 16 and 24 years (31.42%), and the gender, male (56%). Conclusion: The facial injuries resulting from interpersonal violence in the analyzed period amounted to 16.17% of the total of cases, with 5.07% of these presenting reports of dental involvement. KEYWORDSForensic Dentistry; Injuries; Violence.
Cell proliferation assay – method optimisation for in vivo labeling of DNA in the rat forestomach
Authors: Joksić Gordana , Mićić Mileva , Filipović Jelena , Drakulić Dunja , Stanojlović Miloš , Čalija Bojan , Valenta Šobot Ana , Demajo Miroslav , Nilsson Robert 
Published: March 2017

Abstract
The study of cell proliferation is a useful tool in the fields of toxicology, pathophysiology and pharmacology. Cell proliferation and its degree can be evaluated using 5-bromo-2′-deoxyuridine which is incorporated into the newly synthesized DNA. The aim of this study was the optimization of subcutaneous application of 5-bromo-2′-deoxyuridine implantation for continuous and persistent marking of proliferating cells in the rat forestomach. 3-tert-Butyl-4-hydroxyanisole was used as the agent that ensures cell proliferation. In order to determine the optimal dose for proliferating cells labeling, 5-bromo-2′-deoxyuridine doses of 50 mg, 100 mg, 200 mg or 350 mg were implemented 2 days prior to sacrifice by flat-faced cylindrical matrices. Immunohistochemical analysis using 5-bromo-2′-deoxyuridine in situ detection kit was performed for the detection of 5-bromo-2′-deoxyuridine labeled cells. The results showed that for adult rats, the optimum 5-bromo-2′-deoxyuridine dose is 200 mg per animal for subcutaneous application. The here described manner of 5-bromo-2′-deoxyuridine in vivo labeling provides a simple, efficient, and reliable method for cell labeling, and at the same minimizes stress to animals.
Renal vasography in mink (Mustela vison)
Authors: Mrvić Verica , Avdić Rizah , Hadžiomerović Nedžad , Tandir Faruk , Prokić Branislav , Tomašević Ratko , Prokić Bogomir Bolka 
Published: March 2017

Abstract
This paper presents the results of the research on renal blood vessels of the mink. The main goal of this research is to provide a unique insight in renal vessel constellation and thereby contributes to the amount and quality of the available data on the cardiovascular system of the mink, since the data found in the available literature regarding this specific field is rather poorly documented. Blood vessels of the mink kidney were studied by dissection and corrosion injection technique. The renal artery and its branches, and the lobar, interlobar and interlobular arteries are terminal arteries and they do not anastomose between each other. The arterial system is characterized by two independent vascular areas, supplied by the dorsal and ventral lobar artery. Lobar arteries divide the kidney horizontally into a dorsal and ventral half, while lobar veins divide it vertically into the cranial and caudal half. The renal vein is formed from the cranial and caudal lobar vein. The obtained results are compared with relevant literature findings on renal blood supply of a dog and other sympatric carnivores.
Two morphologically distinct forms of Demodex mites found in dogs with canine demodicosis from Vladivostok, Russia
Authors: Moskvina Tatyana Vladimirovna 
Published: March 2017

Abstract
The aim of this study was to investigate the morphology of Demodex canis and Demodex sp. cornei found in six dogs with canine demodicosis. A deep skin scraping technique was used for Demodex mite detection. Measurement data of 52 adult D. canis mites (26 females, 25 males and one specimen whose sex could not be determined) and 39 adult Demodex sp. cornei mites (22 females, 14 males and three specimens whose sex could not be determined) were reported. The correlation between body size of both Demodex species were estimated by the Student’s t-test. There was a significant correlation between short-tail and long-tail forms and total body length and length of the podosoma and opisthosoma (p<0.05). A significant difference was not found between the length of the gnathosoma and short-tail and long-tail forms (p>0.05). Demodex sp. cornei and D. canis, found in dogs from Vladivostok, were smaller than species from other countries. However, the present data did not significantly differ from other studies with D. canis and Demodex sp. cornei descriptions.
Z-cells and oogonia/oocytes in the advanced process of autophagy are the dominant altered cells in the ovaries of hypothyroid newborn rats
Authors: Danilović Luković Jelena , Korać Aleksandra , Milošević Ivan , Lužajić Tijana , Milanović Zorana , Kovačević Filipović Milica , Radovanović Anita 
Published: March 2017

AbstractInduced prenatal hypothyroidism in rat pups leads to accelerated primordial follicle assembly and premature follicular atresia with ovary failure. This work investigates the influence of maternal hypothyroidism induced with 6-n-propyl-2-thyouracil (PTU) on the number and morphology of oogonia/oocytes in newborn rat pups with light and transmission electron microscopy. Expression of apoptosis and autophagy markers in oogonia/oocytes were examined using immunohistochemistry. Hypothyroid newborn pups had a decreased number of mitotic and resting oogonia, while the number of altered oogonia/oocytes was increased. Ultrastructural observations revealed the increased presence of degenerated pachytene oocytes (Z-cells) and oogonia/oocytes undergoing autophagy, apoptosis and combined apoptosis and autophagy, in this group. The most abundant altered oogonia/oocytes in the hypothyroid group were those with morphological features of advanced autophagy and Z-cells. The percentage of TUNEL (terminal deoxynucleotidyl transferase dUTP nick end labeling) positive oogonia/oocytes was significantly lower in the hypothyroid group. No significant difference was recorded in the expression of caspase-3, ATG7 and LC3 possibly reflecting that these proteins were not involved in the oogonia/oocyte alteration process during prenatal rat hypothyroidism. The obtained results indicate that developmental hypothyroidism in the offspring enhances the number of Z-cells and oogonia/oocytes altered with the advanced process of autophagy.