bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: CO Labilization and Intramolecular Hydride Transfer Reactions in Group VI (Cr, Mo, W) Metal‐Platinum Heterobimetallic μ‐Phosphido Hydrido Carbonyl Complexes.
Authors: POWELL J. , GREGG M. R. , SAWYER J. F. 
Published: May 2016

AbstractOxidative addition of the P‐H bond of the sec. phosphine complexes (I) to the Pt(0) complex (II) gives the phosphide‐bridged products (III) which loses rapidly CO (reversible process) to give the μ‐hydrido‐μ‐phosphido complexes (IVa) via a Pt‐assisted mechanism.
ChemInform Abstract: Synthesis of “PtRu2” and “PtRu3” Heterometallic Complexes from the Reaction of Ru3(CO)11(PPh2H) with Zerovalent Complexes of Platinum. Single‐Crystal X‐Ray Diffraction Studies of PtRu2(μ‐PPh2)(μ‐H)(CO)7(PCy3) and PtRu3(μ‐PPh2)(μ‐H)(CO)9(PCy3).
Authors: POWELL J. , BREWER J. C. , GULIA G. , SAWYER J. F. 
Published: May 2016

AbstractThe reaction of the Ru3 cluster (I) with the tricyclohexylphosphine‐Pt(0) complex (II) gives the tetranuclear PtRu3 cluster (III) (space group P21/c, Z=4) and the trinuclear Ru2Pt cluster (IVa) ( P21/n, Z=4) as the major products together with several minor "RuxPty" species.
ChemInform Abstract: Coriamyrtin and Tutin. A Crystallographic and Conformational Study.
Authors: GULBIS J. M. , MACKAY M. F. , WONG M. G. 
Published: May 2016

AbstractThe structural and pharmacological similarity of coriamyrtin (Ia) (space group P212121; Z=4) and tutin (Ib) (space group P1; Z=1) to picrotoxinin suggests that all three compounds (convulsants from Coriaria species) act as the same inhibitory synapses and utilize the same binding site.
ChemInform Abstract: Synthesis of α‐Damascone and 1‐(2,6,6‐Trimethyl‐2‐tetrahydropyranyl)‐2‐alken‐1‐ones.
Authors: ERMAN M. B. , PRIBYTKOVA I. M. , GULYI S. E. , BOGOMOLOVA O. A. , CHERKAEV G. V. , AUL'CHENKO I. S. , MOCHALIN V. B. 
Published: May 2016

Abstractα‐Damascone (V) is prepared starting from α‐cyclocitral (I) by a novel and more convenient procedure.
ChemInform Abstract: Preparation and Conformational Analysis of Vancomycin Hexapeptide and Aglucovancomycin Hexapeptide.
Authors: BOOTH P. M. , WILLIAMS D. H. 
Published: May 2016

AbstractThe preparations of the hexapeptides (Ib) and (Ic) derived from the antibiotic (Ia) and its agluco derivative are described.
ChemInform Abstract: Asymmetric Reduction of the Prochiral Carbon‐Carbon Double Bond of Methyl 2‐Chloro‐2‐alkenoates by Use of Fermenting Bakers′ Yeast.
Authors: UTAKA M. , KONISHI S. , MIZUOKA A. , OHKUBO T. , SAKAI T. , TSUBOI S. , TAKEDA A. 
Published: May 2016

AbstractAsymmetric reduction of the methyl E‐2‐chloroalkenoates (I) using fermenting bakers yeast gives the corresponding methyl 2‐chloroalkanoates (R)‐(II) with moderate up to satisfactory optical purity.
ChemInform Abstract: High Frequency Capacitance‐Voltage Characteristics of Thermally Grown SiO2 Films on β‐SiC.
Authors: TANG S. M. , BERRY W. B. , KWOR R. , ZELLER M. V. , MATUS L. G. 
Published: May 2016

AbstractSiO2 films on β‐SiC are thermally grown either under dry (O2 stream, 1000 °C) or wet (argon stream loaded with H2O vapor, 1150 °C) conditions and studied by C‐V measurements.
ChemInform Abstract: 95Mo NMR and Vibrational Spectroscopic Studies of Molybdenum(VI) Species in Aqueous Solutions and Solvent Extracts from Hydrochloric and Hydrobromic Acid: Evidence for the Complexes (Mo2O5(H2O)6)2+, (MoO2X2(H2O)2) (X: Cl or Br), and (MoO2Cl4)2‐.
Authors: CODDINGTON J. M. , TAYLOR M. J. 
Published: May 2016

AbstractThe NMR, IR, and Raman spectroscopic results obtained for acidified Na2MoO4 solutions indicate the presence of the species (Mo7O24)6‐, (Mo8O26)4‐, and (Mo36O112(H2O)16)8‐. In 2‐6 M HNO3 or HClo4 solutions of Na2MoO4, (Mo2O5(H2O)6)2+ is identified as predominant Mo(VI) species.
ChemInform Abstract: Aqueous Isopolymolybdates(VI): An Oxygen‐17 and Molybdenum‐95 NMR Study.
Authors: HOWARTH O. W. , KELLY P. , PETTERSSON L. 
Published: May 2016

Abstract(Mo7O24)6‐, (HMo7O24)5‐, and (Mo8O26)4‐ are clearly detected in acidified aqueous solutions of (MoO4)2‐ (pH 1.2‐6) by 17O and 95Mo NMR.
ChemInform Abstract: Photoelectrochemistry and Interfacial Energetics of Titanium Dioxide Photoelectrodes in Fluoride‐Containing Solutions
Authors: WANG C. M. , MALLOUK T. E. 
Published: May 2016

Abstractsuch as anhydrous HF/NaF and MeCN/Et4NF solutions are studied by I‐V and ac impedance measurements.
ChemInform Abstract: A Molybdate Treatment for Enhancing the Passivity of Aluminum in Chloride‐Containing Environments.
Authors: SHAW B. A. , DAVIS G. D. , FRITZ T. L. , OLVER K. A. 
Published: May 2016

AbstractIt is demonstrated that the pitting resistance of aluminum can be significantly improved by electrochemical incorporation of Mo into the aluminum passive film.
ChemInform Abstract: Formation of Perovskite Structure La1‐xCaxCrO3 Films by Electrodeposition.
Authors: KONNO H. , TOKITA M. , FURUICHI R. 
Published: May 2016

AbstractCathodic polarization of a Pt electrode in an aqueous solution of La(NO3)3, Ca(NO3)2, and (NH4)2Cr2O7 (pH 2.3) results in the deposition of a (LaOH)1‐xCax(CrO4)·nH2O film.
ChemInform Abstract: Addition of Cyanide Ion to Nicotinamide Cations in Acetonitrile. Formation of Non‐Productive Charge‐Transfer Complexes.
Authors: ENGBERSEN J. F. J. , KOUDIJS A. , SLEIDERINK H. M. , FRANSSEN M. C. R. 
Published: May 2016

AbstractMixing of equal amounts of 1‐benzylnicotinamides (Ia) and KCN (II) results in the immediate formation of a transient absorption band at 375 nm which is ascribed to a CT complex.
ChemInform Abstract: Synthesis and Transannular Diels‐Alder Reaction of a cis‐trans‐trans and a trans‐cis‐cis 13‐Membered Macrocyclic Trienone.
Authors: MARINIER A. , BAETTIG K. , DALLAIRE C. , PITTELOUD R. , DESLONGCHAMPS P. 
Published: May 2016

AbstractBoth the title compounds (I) and (V) are prepared in 13‐15 steps starting from cyclohexene.
ChemInform Abstract: Concomitant (2,3)Sigmatropic Rearrangement of Allylic Sulfilimines and Intramolecular N‐Alkylation. Synthesis of 2‐Vinyl‐Substituted Cyclic Amines.
Authors: DOLLE R. E. , LI C.‐S. , SHAW A. N. 
Published: May 2016

AbstractThe ω‐bromo or ω‐tosyloxy allylic sulfides (I) undergo amination accompanied by cyclization upon consecutive treatment with chloramine T, triethyl phosphite, and aqueous sodium hydroxide, yielding the N‐tosyl‐2‐vinylazacycloalkanes (III).
ChemInform Abstract: Captodative Substituent Effects. Part 49. ESR Study of Carbon‐Centered Transient Radicals Using α‐tert.‐Butylthioacrylonitrile as Radical Trap.
Authors: MERENYI R. , JANOUSEK Z. , VIEHE H. G. , MIGNANI S. 
Published: May 2016

AbstractThe title compound (III) is found to be the most useful radical trap because of its easy synthesis, its aptitude to trap nucleophilic as well as electrophilic radicals such as (II) (a total of 29 examples is tabulated), and the facile interpretation of the ESR spectra of radical adducts (IV) which are in equilibrium with their dimers (V).
ChemInform Abstract: Addition of Cyclohexane to Slowly Reacting H2‐O2 Mixtures at 480 °C.
Authors: GULATI S. K. , WALKER R. W. 
Published: May 2016

AbstractThe kinetics of the reactions OH + c‐C6H12 → c‐C6H11 + H2O (k = (1.41 ±0.20)·1010) and H + c‐C6H12 → c‐C6H11 + H2 (k = (2.8 ±0.4)·109 dm3/mol·s) measured show that the rates of H and OH attack on an individual CH2 group in cyclohexane and in linear alkanes are effectively indistinguishable.
ChemInform Abstract: Stereoselective Hydrogenation via Dynamic Kinetic Resolution.
Authors: NOYORI R. , IKEDA T. , OHKUMA T. , WIDHALM M. , KITAMURA M. , TAKAYA H. , AKUTAGAWA S. , SAYO N. , SAITO T. , TAKETOMI T. , KUMOBAYASHI H. 
Published: May 2016

AbstractThe Ru‐catalyzed hydrogenation of the racemic ketones (I) proceeds stereoselectively to provide nearly exclusively the syn‐((2S,3R)‐) alcohols (II).
ChemInform Abstract: Thiols as Polarity Reversal Catalysts for Hydrogen‐Atom Transfer from Organosilanes to Alkyl Radicals: Reduction of Alkyl Halides by Triethylsilane.
Authors: ALLEN R. P. , ROBERTS B. P. , WILLIS C. R. 
Published: May 2016

AbstractThe alkyl halides (I) are reduced with triethylsilane in the presence of di‐tert‐butyl hyponitrite and tert‐dodecanethiol, producing the alkanes (II).
ChemInform Abstract: Conversion of Long‐Chain Terminal Alcohols and Secondary Amines into Tertiary Amines Using Dichlorotris(triphenylphosphine)ruthenium(II) as Catalyst.
Authors: GANGULY S. , JOSLIN F. L. , ROUNDHILL D. M. 
Published: May 2016

AbstractThe title complex acts as a homogeneous catalyst for the conversion of terminal alcohols such as (I) and secondary amines (II) into tertiary amines (III) (16 examples given in a table).
ChemInform Abstract: Unequivocal Synthesis of the Four d,l‐Pairs of 3‐Substituted 2‐Aminonorbornane‐2‐carboxylic Acids.
Authors: AVENOZA A. , CATIVIELA C. , MAYORAL J. A. , ROY M. A. 
Published: May 2016

AbstractThe cycloadducts (III) and (IV) are obtained by Diels‐Alder reaction of the components (I) and (II).
ChemInform Abstract: Cyclohepta(l)phenanthrenylium Ions. Intramolecular Cyclization of 2‐Biphenylylcycloheptatrienes.
Authors: YAMAMURA K. , MIYAKE H. , AZUMI K. , MURATA I. 
Published: May 2016

AbstractThe 2‐biphenylylcycloheptatrienes (I) ‐ (IV) react with 1 equiv. of trityl tetrafluoroborate (V) to yield the tropylium salts (VI).
ChemInform Abstract: Biomimetic Radical Cyclizations: Synthesis and Biosynthesis of Benzodihydropyrans and ‐furans.
Authors: WALKINGTON A. J. , WHITING D. A. 
Published: May 2016

AbstractThe thiohydroxamate (I) is irradiated in the presence of acrylonitrile (II), tributylstannane, and AIBN to produce the cyanopropylphenol ether (III).
ChemInform Abstract: Synthesis and Antifungal Activity of Some Amidrazone Derivatives.
Authors: VIO L. , MAMOLO M. G. , RONSISVALLE G. , OLIVERI S. , GREGO A. M. 
Published: May 2016

AbstractThe cyanopyridines (I) react with hydrazine (II), forming the amidrazones (III) which are coupled with the hetaromatic aldehydes (IV) to produce the hetarylmethylenamidrazones (V).
ChemInform Abstract: Novel Entry to the Tropane System by Reaction of Rhodium(II) Acetate‐Stabilized Vinylcarbenoids with Pyrroles.
Authors: DAVIES H. M. L. , YOUNG W. B. , SMITH H. D. 
Published: May 2016

AbstractThe unsaturated diazo compounds (II) react with the N‐carboxyalkylpyrroles (I) in the presence of dirhodium tetraacetate to give the 8‐azabicyclo(3.2.1)octadienes (III).
ChemInform Abstract: The Synthesis and Structure of (7)(3,6)Pyridazinophane.
Authors: GASSMAN P. G. , BOARDMAN G. S. 
Published: May 2016

AbstractThe Diels‐Alder adduct (III), derived from the cycloundecadiene (I) and the triazolinedione (II), is converted to the epoxide (IV) which is cleaved, forming the isomeric semicarbazides (V) and (VI).
ChemInform Abstract: Cycloaddition Reactions of Heteroazadienes. The First Intramolecular Diels‐Alder Reaction of 1‐Thia‐3‐azabutadienes.
Authors: BARLUENGA J. , TOMAS M. , BALLESTEROS A. , LOPEZ L. A. 
Published: May 2016

AbstractReaction of the unsaturated N‐(trimethylsilyl)imines (I) or (VI) with the isothiocyanates (II) results in cyclization to produce the tricyclic trans‐fused 2‐imino‐1,3‐thiazines (III) or (VII).
ChemInform Abstract: Synthesis of Some Derivatives of the New Ring System Pyrrolo(3,4‐f)(1,5)diazocine.
Authors: ZANKOWSKA‐JASINSKA W. , OSTROWSKA K. 
Published: May 2016

AbstractThe novel title compounds (III) may be of pharmacological interest, since the analogous pyrrolo(3,4‐e)(1,5)diazocines are used as tranquilizers or antihypertensive agents.
ChemInform Abstract: A Metal‐Directed Pyrazoline ‐ 1,5‐Diazapentadiene Rearrangement of a Novel (2 + 2)Macrocycle: Crystal and Molecular Structures of L3 and (Ni2(L2))·5H2O.
Authors: CONSTABLE E. C. , DOYLE M. J. , ELDER S. M. , RAITHBY P. R. 
Published: May 2016

AbstractPyridine‐2,6‐dicarbohydrazide (I) cyclizes with pentane‐2,4‐dione (II) to produce the macrocyclic hydrazide (III) which reacts with nickel(II) acetate (IV) under rearrangement, yielding the V‐shaped binuclear complex (V).
ChemInform Abstract: The Reactions of 3‐Acetyl‐2H‐1‐benzopyran‐2‐ones with Ammonia and Ammonium Acetate.
Authors: O'CALLAGHAN C. N. , MCMURRY T. B. H. 
Published: May 2016

AbstractThe reaction of two equivalents of the acetylbenzopyranone (I) with one equivalent of NH3 (II) or AcONH4 (IV) leads to the products (III) or (V).
ChemInform Abstract: A Novel Macrocycle Containing the 4,5‐Dithio‐1,3‐dithiole‐2‐thione Unit and a Related Macrocycle Incorporating the Tetrathiafulvalene Moiety.
Authors: GIRMAY B. , KILBURN J. D. , UNDERHILL A. E. , VARMA K. S. , HURSTHOUSE M. B. , HARMAN M. E. , BECHER J. , BOJESEN G. 
Published: May 2016

AbstractThe bis(benzoylthio)dithiolethione (I) is converted into the dimercapto disodium salt (III) which reacts with 2,6‐bis(bromomethyl)pyridine (IV) to form the macrocycle (V).
ChemInform Abstract: A New Route to Highly Enantiomerically Enriched (Z)‐(1‐Methyl‐2‐butenyl)boronic Esters.
Authors: STUERMER R. + 
Published: May 2016

AbstractThe boronic ester (III) is obtained by the diastereoselective reaction of the chiral borate (I) with one isomer of a racemic mixture of the Grignard reagent (II).
ChemInform Abstract: New Dihydrazido and Oxyamido Derivatives of Phosphoric and Thiophosphoric Acid with Bis(2‐chloroethyl)amido Substituents.
Authors: GIERSDORF K. , DIEFENBACH U. , ENGELHARDT U. 
Published: May 2016

AbstractThe reaction of (Ia) with 1,2‐dimethylhydrazine (II) gives the dihydrazide (III), whereas the corresponding reaction of (Ib) yields the monosubstitution product (VI).
ChemInform Abstract: Unexpected Synthesis of a 1,4‐Diaza‐2σ3λ3,3σ4λ5‐diphospholene.
Authors: MAJORAL J.‐P. , ROQUES C. , MAZIERES M. R. , JAUD J. , SANCHEZ M. 
Published: May 2016

AbstractTreatment of the bissilyldichlorophosphine (I) with the N‐silylated phenylamidine (II) results in cyclization, producing the diazadiphospholene (III).
ChemInform Abstract: Reaction of VOCl3 with Alcohols in the Presence of Nitrogen‐Containing Hydrogen Chloride Acceptors.
Authors: MAGOMEDOV G. K. I. , MOROZOVA L. V. , KUSAINOVA K. M. , BLOKHINA E. I. , MEDVEDEVA A. V. , BELETSKAYA I. P. 
Published: May 2016

AbstractThe preparation of the trialkyl vanadates (III) from vanadyl chloride (I) and the alcohols (II) in the presence of bases is studied in detail.
ChemInform Abstract: Synthesis, Molecular and Electronic Structure, and Properties of Mononuclear Trimethylphosphine‐Containing Cyclopentadienyl Derivatives of Molybdenum(III) and Molybdenum(IV). Direct Evidence of Mo(III)‐P π Back‐Bonding.
Authors: KRUEGER S. T. , POLI R. , RHEINGOLD A. L. , STALEY D. L. 
Published: May 2016

AbstractThe Mo(III) complexes (IV) are paramagnetic, low‐spin, mononuclear 17‐electron compounds.
ChemInform Abstract: Formation of Bis(o‐benzosemiquinonediiminato)cobalt(III) Derivatives by Oxidation of o‐Phenylenediaminecobalt(II) Complexes with O2.
Authors: NEMETH S. , SIMANDI L. I. , ARGAY G. , KALMAN A. 
Published: May 2016

AbstractOn exposure to pure O2 of a MeOH solution containing Co(II) perchlorate (I), two equiv. o‐phenylenediamine (II) and two equiv. EPh3 (III), the square pyramidal Co(III) complexes (IV) are formed.
ChemInform Abstract: Isolation, Characterization, and Kinetics of Formation of the cis and trans Isomers of Bis(acetonitrile)dichloroplatinum(II).
Authors: FANIZZI F. P. , INTINI F. P. , MARESCA L. , NATILE G. 
Published: May 2016

AbstractBy the known standard procedure a mixture of the cis and trans isomers (III) and (IV) is obtained.
ChemInform Abstract: Structural Variations of N‐Acetylneuraminic. Part 15. Synthesis of 9‐Deoxy‐, 7,9‐Dideoxy‐, and 4,7,9‐Trideoxy‐N‐acetylneuraminic Acid and Their Behavior Toward CMP‐Sialate Synthase.
Authors: SCHREINER E. , CHRISTIAN R. , ZBIRAL E. 
Published: May 2016

AbstractThe procedures used for the synthesis of the title compound (VI) are also applied to the preparation of the derivatives (IX) and (XII) (no yield given).
ChemInform Abstract: Sulfur‐Containing Polybromoindoles from the Red Alga Laurencia brongniartii.
Authors: TANAKA J. , HIGA T. , BERNARDINELLI G. , JEFFORD C. W. 
Published: May 2016

AbstractThe new polybromoindoles (I), (II) (space group P21/c; Z=4), (III) (space group P21/n; Z=4) and (VII) are isolated from the title species.
ChemInform Abstract: Stereochemistry of Bisoxiranes of Vitamin D3‐4‐Phenyl‐triazoline‐3,5‐dione Adducts: X‐Ray Structure Analysis of One of Their Benzoyl Derivatives.
Authors: REISCHL W. , KRATKY C. , SHELDRICK G. M. , ZBIRAL E. 
Published: May 2016

AbstractComplete epoxidation of the vitamin D3‐phenyltriazolinedione adducts (I) with MCPBA generates four diastereomeric bisoxiranes such as (IIa).
ChemInform Abstract: A Convenient Preparation of (8R),25‐Dihydroxy‐9,10‐seco‐4,6,10(19)‐cholestatrien‐3‐one.
Authors: REISCHL W. 
Published: May 2016

AbstractThe title compound (III), a new metabolite of 25‐hydroxyvitamin D3 (I) from the murine myeloid leukemia cell line M 1, is available from (I).
ChemInform Abstract: Enzymes in Organic Synthesis. Part 15. Enzymatic Preparation of Optically Active Cyanohydrin Acetates.
Authors: VAN ALMSICK A. , BUDDRUS J. , HOENICKE‐SCHMIDT P. + , LAUMEN K. , SCHNEIDER M. P. 
Published: May 2016

AbstractEnzymatic hydrolysis of the racemic cyanohydrin acetates (I) at a constant pH followed by work‐up of the product mixture yields the optically active cyanohydrin acetates (II).
ChemInform Abstract: Dip‐Coating of Sb‐Doped SnO2 Films by Ethanolamine‐Alkoxide Method.
Authors: TAKAHASHI Y. , WADA Y. 
Published: May 2016

AbstractTransparent, highly conducting thin Sb‐doped SnO2 films are deposited on glass substrates by a dip‐coating method using a solution of Sn(O‐iPr)4, Sb(OEt)3, isopropanol, triethanolamine, and H2O. The resistivity of the films slightly depends on their thickness.
Association Between Sedentary Lifestyle and Diastolic Dysfunction Among Outpatients With Normal Left Ventricular Systolic Function Presenting to a Tertiary Referral Center in the Middle East
Authors: Matta Stephanie , Chammas Elie , Alraies Chadi , Abchee Antoine , AlJaroudi Wael 
Published: May 2016

ABSTRACTBackgroundSedentary lifestyle has become prevalent in our community. Recent data showed controversy on the effect of regular exercise on left ventricular compliance and myocardial relaxation.HypothesisWe sought to assess whether physical inactivity is an independent predictor of diastolic dysfunction in or community, after adjustment for several covariates.MethodsConsecutive outpatients presenting to the echocardiography laboratory between July 2013 and June 2014 were prospectively enrolled. Clinical variables were collected prospectively at enrollment. Patients were considered physically active if they exercised regularly ≥3× a week, ≥30 minutes each time. The primary endpoint was presence of diastolic dysfunction.ResultsThe final cohort included 1356 patients (mean age [SD] 52.9 [17.4] years, 51.3% female). Compared with physically active patients, the 1009 (74.4%) physically inactive patients were older, more often female, and had more comorbidities and worse diastolic function (51.3% vs 38.3%; P < 0.001). On univariate analysis, physical inactivity was associated with 70% increased odds of having diastolic dysfunction (odds ratio: 1.70, 95% confidence interval: 1.32‐2.18, P < 0.001). There was significant interaction between physical activity and left ventricular mass index (LVMI; P = 0.026). On multivariate analysis, patients who were physically inactive and had LVMI ≥ median had significantly higher odds of having diastolic dysfunction (odds ratio: 2.82, 95% confidence interval: 1.58‐5.05, P < 0.001).ConclusionsIn a large, prospectively enrolled cohort from a single tertiary center in the Middle East, physically inactive patients with increased LVMI had 2‐ to 3‐fold increased odds of having diastolic dysfunction after multivariate adjustment.
Sex disparities in use of chemotherapy and survival in patients with advanced bladder cancer
Authors: Rose Tracy L. , Deal Allison M. , Nielsen Matthew E. , Smith Angela B. , Milowsky Matthew I. 
Published: May 2016

BACKGROUNDWomen with advanced bladder cancer have inferior survival compared with men. However, women treated on clinical trials do not appear to have a survival disadvantage. Less frequent administration of systemic chemotherapy in women with advanced bladder cancer may contribute to their inferior survival.METHODSThe authors identified patients diagnosed with stage IV bladder cancer from 1998 through 2010 using the National Cancer Data Base, a national outcomes database that includes 70% of all newly diagnosed cancer cases in the United States. Sex differences in demographics, systemic chemotherapy administration, and overall survival (OS) were compared.RESULTSA total of 23,981 patients were identified (35% of whom were female). Compared with men, women were older, more likely to be black, and less likely to be insured (P<.01 for all). The Charlson‐Deyo comorbidity score did not differ between men and women. Women were less likely to receive systemic chemotherapy than men (45% vs 52%; adjusted relative risk, 0.91 [95% confidence interval (95% CI), 0.88‐0.94]). Women had a lower median OS compared with men (8.0 months [95% CI, 7.7‐8.3 months] vs 9.8 months [95% CI, 9.5‐10.0 months]; P<.001). OS remained lower for women on multivariable analysis, even after adjusting for the administration of systemic chemotherapy (hazard ratio for death, 1.11 [95% CI, 1.08‐1.15]).CONCLUSIONSWomen are less likely than men to receive systemic chemotherapy for advanced bladder cancer and this difference may partially account for the poorer OS observed in women. However, OS remains lower in women independent of chemotherapy use, and may be related to unmeasured comorbidities, functional status, or tumor biology. Cancer 2016;122:2012–20. © 2016 American Cancer Society.
Early impact of Medicare accountable care organizations on cancer surgery outcomes
Authors: Herrel Lindsey A. , Norton Edward C. , Hawken Scott R. , Ye Zaojun , Hollenbeck Brent K. , Miller David C. 
Published: May 2016

BACKGROUNDAccountable care organizations (ACOs) were established to improve care and outcomes for beneficiaries requiring highly coordinated, complex care. The objective of this study was to evaluate the association between hospital ACO participation and the outcomes of major surgical oncology procedures.METHODSThis was a retrospective cohort study of Medicare beneficiaries older than 65 years who were undergoing a major surgical resection for colorectal, bladder, esophageal, kidney, liver, ovarian, pancreatic, lung, or prostate cancer from 2011 through 2013. A difference‐in‐differences analysis was implemented to compare the postimplementation period (January 2013 through December 2013) with the baseline period (January 2011 through December 2012) to assess the impact of hospital ACO participation on 30‐day mortality, complications, readmissions, and length of stay (LOS).RESULTSAmong 384,519 patients undergoing major cancer surgery at 106 ACO hospitals and 2561 control hospitals, this study found a 30‐day mortality rate of 3.4%, a readmission rate of 12.5%, a complication rate of 43.8%, and a prolonged LOS rate of 10.0% in control hospitals and similar rates in ACO hospitals. Secular trends were noted, with reductions in perioperative adverse events in control hospitals between the baseline and postimplementation periods: mortality (percentage‐point reduction, 0.1%; P = .19), readmissions (percentage‐point reduction, 0.4%; P = .001), complications (percentage‐point reduction, 1.0%; P < .001), and prolonged LOS (percentage‐point reduction, 1.1%; P < .001). After accounting for these secular trends, this study identified no significant effect of hospital participation in an ACO on the frequency of perioperative outcomes (difference‐in‐differences estimator P values, .24‐.72).CONCLUSIONSEarly hospital participation in the Medicare Shared Savings Program ACO program was not associated with greater reductions in adverse perioperative outcomes for patients undergoing major cancer surgery in comparison with control hospitals. Cancer 2016. © 2016 American Cancer Society. Cancer 2016;122:2739–2746. © 2016 American Cancer Society.