bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enantioselective Epoxidation of Electron‐Deficient Alkenes Catalyzed by Manganese Complexes with Chiral N4 Ligands Derived from Rigid Chiral Diamines
Authors: Chen Xiangning , Gao Bao , Su Yijin , Huang Hanmin 
Published: May 2017

AbstractA series of tetradentate sp2N/sp3N hybrid chiral N4 ligands derived from rigid chiral diamines were synthesized, which enabled the first manganese‐catalyzed enantioselective epoxidation of electron‐deficient alkenes with hydrogen peroxide (H2O2) as an oxidant. The reaction furnishes enantiomerically pure epoxy amides, epoxy ketones as well as epoxy esters in good yields and excellent enantioselectivities (up to 99.9% ee) with lower catalyst loading. Preliminary studies on structure–activity relationship demonstrated that maintaining comparatively lower electron‐donating ability of the sp3N and relatively higher electron‐donating ability of sp2N of the N4 ligands is beneficial to getting higher activity and selectivity, thus providing us a new view to understand epoxidation with H2O2.magnified image
Occurrence and predictors of acute stent recoil—A comparison between the xience prime cobalt chromium stent and the promus premier platinum chromium stent
Authors: van Bommel Rutger J. , Lemmert Miguel E. , van Mieghem Nicolas M. , van Geuns Robert‐Jan , van Domburg Ron T. , Daemen Joost 
Published: May 2017

ObjectivesTo compare the occurrence of acute stent recoil in two different stent types (platinum chromium and cobalt chromium) and identify the potential predictors of significant acute stent recoil.BackgroundAcute stent recoil is frequently observed after percutaneous coronary intervention and has been associated with in‐stent restenosis and in‐stent thrombosis. Different stent designs may result in varying degrees of stent recoil.MethodsFrom a registry of “all‐comers” treated with either the Xience Prime Cobalt Chromium or Promus Premier Platinum Chromium stent, a random sample of 100 patients was drawn. Acute stent recoil was defined as the minimal luminal diameter (MLD) of the last inflated balloon minus the MLD after, divided by the MLD of the last inflated balloon. Significant acute stent recoil was defined as recoil ≥10%.ResultsA total of 123 lesions (61 Xience Prime vs 62 Promus Premier) in 100 patients were analyzed. Acute stent recoil of 8.6 ± 4.9% was observed in the Xience Prime group versus 8.7 ± 4.2% in the Promus Premier group, P = 0.970. In a multivariate model for significant acute stent recoil, a stent/vessel ratio ≥1 (hazard ratio 4.64 [1.94–11.12], P = 0.001), a balloon/stent ratio >1 (hazard ratio 3.83 [1.12–13.14], P = 0.032) and direct stenting (hazard ratio 0.42 [0.18–0.96], P = 0.039) were identified as predictors.ConclusionsNo significant differences were observed in the extent of acute stent recoil between the Xience Prime and the Promus Premier stent. A larger stent/vessel ratio, a larger balloon/stent ratio, and direct stenting were associated with significant acute stent recoil ≥10%. © 2017 Wiley Periodicals, Inc.
Feasibility and safety of transfemoral sheathless portico aortic valve implantation: Preliminary results in a single center experience
Authors: Taramasso Maurizio , Denegri Andrea , Kuwata Shingo , Rickli Hans , Haager Philipp K. , Sütsch Gabor , Rodriguez Cetina Biefer Hector , Kottwitz Jan , Nietlispach Fabian , Maisano Francesco 
Published: May 2017

BackgroundFeasibility of transfemoral (TF) transcathteter aortic valve replacement (TAVR) is limited by the smallest diameter, the calcification and tortuosity of the iliofemoral access vessels. The use of the Portico system without delivery sheath results in significantly lower profile delivery system compared to standard technique. We herein report our single center experience, feasibility and safety of such an approach.MethodsThe Portico valve was implanted sheathless in 81 high‐risk patients with severe aortic stenosis utilizing percutaneous femoral access. Mean minimal diameter of the ileo‐femoral arterial access was 7.06 ± 1.89 mm. In most cases a multidetector computed tomography was performed before the intervention to assess the feasibility of vascular access and for aortic annulus measurements. The vascular access site was preclosed using two ProGlide suture systems.ResultsDevice implantation was successful 98.7% of patients. Valve recapturing and repositioning as well as valve‐in‐valve deployment was performed in only one case (1.2%). There were no infarctions, 2 strokes (2.4%) and 2 acute kidney failure (2.4%), 1 major vascular complication1 (1.2%) 4 major bleedings (4.9%), 11 conductions disturbances and relative pace‐maker implantations (14.2%). The mean gradient decreased from 42.3 ± 17 to 6.3 ± 2.78 mm Hg. Paravalvular regurgitation as assessed by TTE at discharge was absent or trivial in 19 patients, mild in 60 and moderate 1. Thirty‐day mortality was 2.4%.ConclusionsSheathless use of the Portico valve is feasible and appears to be safe, with excellent rates of complications and mortality in the short‐term. Such an approach has the potential to further expand feasibility of TF TAVR to patients with severe peripheral arterial disease. Feasibility in patients with smaller femoral access and more challenging anatomy has to be proven in further studies. © 2017 Wiley Periodicals, Inc.
Risk of cataract among interventional cardiologists and catheterization lab staff: A systematic review and meta‐analysis
Authors: Elmaraezy Ahmed , Ebraheem Morra Mostafa , Tarek Mohammed Abdelrhman , Al‐Habbaa Ahmed , Elgebaly Ahmed , Abdelmotaleb Ghazy Ahmed , Khalil Adham M. , Tien Huy Nguyen , Hirayama Kenji 
Published: May 2017

ObjectivesWe performed a systematic review and meta‐analysis to assess the risk of developing a radiation‐induced cataract in interventional cardiologists (ICs).BackgroundICs are forced to radiation exposure during cardiac catheterization procedures. Since the eye lens is one of the most radiosensitive organs in the body, ICs are highly susceptible to develop a radiation‐induced cataract.MethodWe performed a systematic literature search of nine electronic databases to retrieve studies that report cataract among interventional cardiologists. Records were screened for eligibility and data were extracted and analyzed using review manager (RevMan) for windows.ResultsEight studies involving 2559 subjects (exposed ICs = 1224) were included. Posterior lens opacity was significantly higher in ICs relative to the control group (RR= 3.21, 95% CI [2.14, 4.83], P < 0.00001). In contrast, there was no significant difference between both groups in cortical lens opacity (RR= 0.69, 95% CI [0.46, 1.06], P = 0.09) and nuclear opacity (RR= 0.85, 95% CI [0.71, 1.02], P = 0.08).ConclusionInterventional cardiologists are at high risk of developing radiation‐induced cataract; therefore, protective measures with high safety rates should be implied. © 2017 Wiley Periodicals, Inc.
The Coumarin‐Dimer Spring—The Struggle between Charge Transfer and Steric Interactions
Authors: Kielesiński Łukasz , Morawski Olaf , Dobrzycki Łukasz , Sobolewski Andrzej L. , Gryko Daniel T. 
Published: May 2017

AbstractThe synthesis of a weakly coupled, strongly polarized coumarin dimer has been achieved for the first time. The three‐step strategy comprises the Skattebøl formylation followed by the Knoevenagel reaction and the formation of a tertiary amide by using a peptide‐type procedure. The molecule consists of two different coumarin moieties: One is a classical donor–acceptor system and the second one possesses a weaker amide donor at the 7‐position. The polarized coumarin dimer can form an electronically conjugated structure possessing an electric dipole larger than that of 7‐(dimethylamino)coumarin‐3‐carboxylic acid. The limited flexibility of the inter‐coumarin connection results in stable conformers of different electric dipole moments and complex photophysics. In the solid state, this compound has a strongly bent conformation with the two coumarin units forming an angle of around 74°. In solution, two conformers are in equilibrium. The existence of the molecule as two conformers in the ground state has been confirmed by optical studies, and further corroborated by molecular calculations. The fluorescence spectra possess a unique feature: A charge‐transfer band (ca. 550 nm) is visible only in nonpolar or weakly polar solvents. Optical spectroscopy studies coupled with molecular calculations allowed us to rationalize this phenomenon: The large amplitude of intramolecular motions is responsible for the conformational isomerization as well as producing a conical intersection between the potential energy surfaces of the excited singlet state and the ground state, which opens an internal conversion channel that effectively competes with the fluorescence of the conformers.
Proteins with Site‐Specific Lysine Methylation
Authors: Wang Zhipeng A. , Liu Wenshe R. 
Published: May 2017

AbstractAs an important epigenetic mark, lysine methylations play critical roles in the regulation of both chromatin and non‐chromatin proteins. There are three levels of lysine methylation, mono‐, di‐, and trimethylation. Each one has turned out to be biologically distinctive. For the biochemical characterization of proteins with lysine methylation, multiple chemical biology methods have been developed. This concept article will highlight these developments and their applications in epigenetic investigation of protein functions.
Atlantic small‐mammal: a dataset of communities of rodents and marsupials of the Atlantic forests of South America
Authors: Bovendorp Ricardo S. , Villar Nacho , de Abreu‐Junior Edson F. , Bello Carolina , Regolin André L. , Percequillo Alexandre R. , Galetti Mauro 
Published: May 2017

AbstractThe contribution of small mammal ecology to the understanding of macroecological patterns of biodiversity, population dynamics, and community assembly has been hindered by the absence of large datasets of small mammal communities from tropical regions. Here we compile the largest dataset of inventories of small mammal communities for the Neotropical region. The dataset reviews small mammal communities from the Atlantic forest of South America, one of the regions with the highest diversity of small mammals and a global biodiversity hotspot, though currently covering less than 12% of its original area due to anthropogenic pressures. The dataset comprises 136 references from 300 locations covering seven vegetation types of tropical and subtropical Atlantic forests of South America, and presents data on species composition, richness, and relative abundance (captures/trap‐nights). One paper was published more than 70 yr ago, but 80% of them were published after 2000. The dataset comprises 53,518 individuals of 124 species of small mammals, including 30 species of marsupials and 94 species of rodents. Species richness averaged 8.2 species (1–21) per site. Only two species occurred in more than 50% of the sites (the common opossum, Didelphis aurita and black‐footed pigmy rice rat Oligoryzomys nigripes). Mean species abundance varied 430‐fold, from 4.3 to 0.01 individuals/trap‐night. The dataset also revealed a hyper‐dominance of 22 species that comprised 78.29% of all individuals captured, with only seven species representing 44% of all captures. The information contained on this dataset can be applied in the study of macroecological patterns of biodiversity, communities, and populations, but also to evaluate the ecological consequences of fragmentation and defaunation, and predict disease outbreaks, trophic interactions and community dynamics in this biodiversity hotspot.
Phylogeny is a powerful tool for predicting plant biomass responses to nitrogen enrichment
Authors: Wooliver Rachel C. , Marion Zachary H. , Peterson Christopher R. , Potts Brad M. , Senior John K. , Bailey Joseph K. , Schweitzer Jennifer A. 
Published: May 2017

AbstractIncreasing rates of anthropogenic nitrogen (N) enrichment to soils often lead to the dominance of nitrophilic plant species and reduce plant diversity in natural ecosystems. Yet, we lack a framework to predict which species will be winners or losers in soil N enrichment scenarios, a framework that current literature suggests should integrate plant phylogeny, functional tradeoffs, and nutrient co‐limitation. Using a controlled fertilization experiment, we quantified biomass responses to N enrichment for 23 forest tree species within the genus Eucalyptus that are native to Tasmania, Australia. Based on previous work with these species' responses to global change factors and theory on the evolution of plant resource‐use strategies, we hypothesized that (1) growth responses to N enrichment are phylogenetically structured, (2) species with more resource‐acquisitive functional traits have greater growth responses to N enrichment, and (3) phosphorus (P) limits growth responses to N enrichment differentially across species, wherein P enrichment increases growth responses to N enrichment more in some species than others. We built a hierarchical Bayesian model estimating effects of functional traits (specific leaf area, specific stem density, and specific root length) and P fertilization on species' biomass responses to N, which we then compared between lineages to determine whether phylogeny explains variation in responses to N. In concordance with literature on N limitation, a majority of species responded strongly and positively to N enrichment. Mean responses ranged three‐fold, from 6.21 (E. pulchella) to 16.87 (E. delegatensis) percent increases in biomass per g N·m−2·yr−1 added. We identified a strong difference in responses to N between two phylogenetic lineages in the Eucalyptus subgenus Symphyomyrtus, suggesting that shared ancestry explains variation in N limitation. However, our model indicated that after controlling for phylogenetic non‐independence, eucalypt responses to N were not associated with functional traits (although post‐hoc analyses show a phylogenetic pattern in specific root length similar to that of responses to N), nor were responses differentially limited by P. Overall, our model results suggest that phylogeny is a powerful predictor of winners and losers in anthropogenic N enrichment scenarios in Tasmanian eucalypts, which may have implications for other species.
Total fatty acid content, antioxidant composition, antioxidant activity, and content of oil from crambe seeds cultivated with phosphorus
Authors: de Aguiar Caroline Mariana , Sampaio Silvio Cesar , Santos Kátia Andressa , da Silva Edson Antônio , Piana Pitágoras Augusto , Richart Alfredo , dos Reis Ralpho Rinaldo 
Published: May 2017

The objective of this study was to determine parameters of crambe oil culvtived with phosphorus (P), with respect to oil content, fatty acid composition, minor compounds, and total antioxidant activity. The experiment followed a randomized block design, with five doses of P (0, 40, 80, 120, and 160 kg P ha−1) and four replications. All results were subjected to analysis of covariance (ANCOVA) 5% significance. The P dose had a negative linear association with δ‐tocopherol and total antioxidant activity, and a positive association with stigmasterol and total carotenoids. P influenced the concentrations of β‐sitosterol and campesterol, whereas the remaining variables (content, α‐tocopherol, β + γ‐tocopherol, fatty acids, total phenolic compounds, and chlorophylla) were not affected. This study show a positive effect the concentrations of compounds that act as antioxidants in crambe oil, which can influence with its oxidation stability.Practical applications:Is relevant the studies concerning the oxidative stability of inedible vegetable oils, such as crambe, in terms of the composition of antioxidants and fatty acids, as this affects the conservation, storage and refining costs, and the quality of the products, considering the many uses of this oil, such as biodiesel, lubricants, corrosion inhibitors, synthetic rubber, plastic films, nylon, and adhesives, among other products.Phosphorus (P) plays an important role in synthesis processes performed by plants such as, functions in cell energy transfer, respiration, and photosynthesis, with an emphasis on processes related to the flow of energy and products stored in grains. In this study, P influenced on the concentrations of compounds such phytosterols and carotenoids, which shows a positive effect in concentrations of compounds that act as antioxidants in crambe oil.
High‐throughput metabolic profiling based on small amount of hepatic cells
Authors: Zhou Lina , Yin Peiyuan , Luo Ping , Tang Ling , Wang Zhichao , Gao Peng , Piao Hailong , Lu Xin , Xu Guowang 
Published: May 2017

AbstractCommon metabolomics platforms require about 106 cells, which has a limited throughput due to the time‐consuming steps of cell culture and preparation. There is a demand for metabolic profiling methods to improve analytical throughput and detection sensitivity based on small amount of cells. In this study, we proposed a high‐throughput scheme, integrating 96‐well plate cell cultivation, in‐situ cell pretreatment, and sensitive dansylation labeling coupled with LC‐MS analysis of metabolites inside HepG2 cells (of the order of magnitude of 103 cells in each well). A simple and rapid cell pretreatment was performed showing good extraction efficiency and good precision (the RSDs smaller than 5%) for polar metabolites. The recovery in metabolite extraction evaluated with three isotope‐labeled amino acids was from 89.7 to 106.3% at low, medium, and high concentrations. The suitability of the method was illustrated by exploring influences of different fatty acids on HepG2 cells.
An hp‐adaptive unstructured finite volume solver for compressible flows
Authors: Jalali Alireza , Ollivier‐Gooch Carl 
Published: May 2017

SummaryThe idea of hp‐adaptation, which has originally been developed for compact schemes (such as finite element methods), suggests an adaptation scheme using a mixture of mesh refinement and order enrichment based on the smoothness of the solution to obtain an accurate solution efficiently. In this paper, we develop an hp‐adaptation framework for unstructured finite volume methods using residual‐based and adjoint‐based error indicators. For the residual‐based error indicator, we use a higher‐order discrete operator to estimate the truncation error, whereas this estimate is weighted by the solution of the discrete adjoint problem for an output of interest to form the adaptation indicator for adjoint‐based adaptations. We perform our adaptation by local subdivision of cells with nonconforming interfaces allowed and local reconstruction of higher‐order polynomials for solution approximations. We present our results for two‐dimensional compressible flow problems including subsonic inviscid, transonic inviscid, and subsonic laminar flow around the NACA 0012 airfoil and also turbulent flow over a flat plate. Our numerical results suggest the efficiency and accuracy advantages of adjoint‐based hp‐adaptations over uniform refinement and also over residual‐based adaptation for flows with and without singularities.
Prognostic factors of maternal near miss events and maternal deaths in a tertiary healthcare facility in India
Authors: Khan Tabassum , Laul Poonam , Laul Anish , Ramzan Mohammed 
Published: May 2017

AbstractObjectiveTo study maternal near miss (MNM) and maternal mortality to identify rectifiable risk factors.MethodsThe present cross‐sectional retrospective study included pregnant women who experienced acute life‐threatening pregnancy‐related adverse events at Deen Dayal Upadhyay hospital, New Delhi, India, between September 1, 2009, and August 31, 2011. Patient data were analyzed to investigate factors associated with MNM events and maternal deaths.ResultsThere were 369 patients included, and 302 MNM events and 67 maternal deaths were recorded. The recorded causes of MNM events included hemorrhage, hypertensive disorders, severe anemia with cardiac failure, organ failure, and infection in 192 (63.6%), 62 (20.5%), 13 (4.3%), 8 (2.6%), and 8 (2.6%) patients, respectively. Higher rates of anemia (P=0.007) and infection (P=0.007) were recorded among patients in the maternal death group than the MNMN group.ConclusionHemorrhage and hypertension were major causes of MNM events and are likely major barriers to reducing maternal mortality in low‐income countries. Anemia and infection were significant prognostic factors of maternal death in the present study. MNM could be used as surrogate for maternal death in the provision of standard obstetric care.
Alternative plasticizer, 4‐cyclohexene‐1,2‐dicarboxylic acid dinonyl ester, for blood containers with protective effects on red blood cells and improved cold resistance
Authors: Morishita Yuki , Nomura Yusuke , Fukui Chie , Fujisawa Ayano , Watanabe Kayo , Fujimaki Hideo , Kumada Hidefumi , Inoue Kaoru , Morikawa Tomomi , Takahashi Miwa , Kawakami Tsuyoshi , Sakoda Hideyuki , Mukai Tomokazu , Yuba Toshiyasu , Inamura Ken‐ichi , Tanoue Akito , Miyazaki Ken‐ichi , Chung Ung‐il , Ogawa Kumiko , Yoshida Midori , Haishima Yuji 
Published: May 2017

AbstractDi (2‐ethylhexyl) phthalate (DEHP), a typical plasticizer used for polyvinyl chloride (PVC), is eluted from PVC‐made blood containers and protects against red blood cell (RBC) hemolysis. However, concerns have arisen regarding the reproductive and developmental risks of DEHP in humans, and the use of alternative plasticizers for medical devices has been recommended worldwide. In this study, we propose that the use of a novel plasticizer, 4‐cyclohexene‐1,2‐dicarboxylic acid dinonyl ester (DL9TH), could help produce more useful and safe blood containers. PVC sheet containing DL9TH and di (2‐ethylhexyl) 4‐cyclohexene‐1,2‐dicarboxylate (DOTH) provides comparable or superior protective effects to RBCs relative to PVC sheet containing DEHP or di‐isononyl‐cyclohexane‐1,2‐dicarboxylate (DINCH®, an alternative plasticizer that has been used in PVC sheets for blood containers). The total amount of plasticizer eluted from DOTH/DL9TH‐PVC sheets is nearly the same as that eluted from DEHP‐PVC sheets. In addition, DOTH/DL9TH‐PVC has better cold resistance than DEHP‐ and DINCH®‐PVC sheets. In vitro and in vivo tests for biological safety based on International Organization for Standardization guidelines (10993 series) suggest that the DOTH/DL9TH‐PVC sheet can be used safely. Subchronic toxicity testing of DL9TH in male rats in accordance with the principles of Organisation for Economic Co‐operation and Development Test Guideline 408 showed that DL9TH did not induce adverse effects up to the highest dose level tested (717 mg/kg body weight/day). There were no effects on testicular histopathology and sperm counts, and no indications of endocrine effects: testosterone, thyroid‐stimulating hormone, follicle‐stimulating hormone, and 17β‐estradiol were unchanged by the treatment, compared with the control group. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 1052–1063, 2018.