bluuebunny/crossref_metadata_2025_split huggingface dataset:
A prospective non-randomized controlled trial testing the effectiveness of psychotherapeutic inpatient treatment of Post-COVID-19 syndrome - study protocol
Authors: Koller Katharina , Kastel-Hoffmann Silke , Herold Regina , Morawa Eva , Lieb Marietta , Krehbiel Johannes , Hohberger Bettina , Erim Yesim 
Published: September 2024

Abstract
Introduction
In addition to physical symptoms such as dyspnea, fatigue, post-exertional malaise, and pain, a subgroup of patients with Post-COVID-19 syndrome (Post-Acute Sequelae of COVID-19, PASC) suffers from mental illnesses such as anxiety, depression, and neurocognitive impairments. To date, there are no causal treatments available for PASC. While initial studies show that psychotherapy improves psychological symptoms, PASC-related fatigue, and psychosocial functioning, further research is needed to evaluate the effectiveness of psychotherapeutic treatment for PASC.

Methods and analysis
This study presents a non-randomized controlled trial aimed at evaluating the effectiveness of a five-week multimodal inpatient psychosomatic treatment program for individuals experiencing PASC symptoms and comorbid mental illness. A total of 118 patients presented at the Post-COVID Center at the Universitätsklinikum Erlangen will be assigned to the intervention group receiving inpatient psychosomatic treatment or the control group receiving treatment as usual. The inclusion criteria for the intervention group are a diagnosis of PASC and at least one condition of mental distress and problems with coping with illness. The primary objective of the intervention is to reduce mental ailments, including depression and anxiety, as well as neurocognitive deficits, and to address PASC symptoms such as fatigue and pain. The core elements of the treatment are psychotherapy in individual and group settings, medical treatment, neurocognitive training, and physical therapy, adapted to the individual’s capacity and oriented towards the concept of pacing. After enrollment, participants will undergo a 6-month follow-up to assess long-term results and the sustainability of the intervention effects.

Discussion
This study examines the effectiveness of inpatient psychotherapeutic treatment in PASC patients with comorbid mental illness in comparison with a control group based on treatment as usual. The results of the study can contribute to the development of evidence-based interventions to address the complex needs of patients with PASC and comorbid mental illness.

Trial registration
German Clinical Trial Register (DRKS), retrospectively registered 15.02.2024 DRKSID DRKS00033562.
Relaxin Modulates the Genomic Actions and Biological Effects of Estrogen in the Myometrium
Authors: Tripathy Sudeshna , Nagari Anusha , Chiu Shu-Ping , Nandu Tulip , Camacho Cristel V , Mahendroo Mala , Kraus W Lee 
Published: September 2024

Abstract
Estradiol (E2) and relaxin (Rln) are steroid and polypeptide hormones, respectively, with important roles in the female reproductive tract, including myometrium. Some actions of Rln, which are mediated by its membrane receptor RXFP1, require or are augmented by E2 signaling through its cognate nuclear steroid receptor, estrogen receptor alpha (ERα). In contrast, other actions of Rln act in opposition to the effects of E2. Here we explored the molecular and genomic mechanisms that underlie the functional interplay between E2 and Rln in the myometrium. We used both ovariectomized female mice and immortalized human myometrial cells expressing wild-type or mutant ERα (hTERT-HM-ERα cells). Our results indicate that Rln modulates the genomic actions and biological effects of estrogen in the myometrium and myometrial cells by reducing phosphorylation of ERα on serine 118 (S118), as well as by reducing the E2-dependent binding of ERα across the genome. These effects were associated with changes in the hormone-regulated transcriptome, including a decrease in the E2-dependent expression of some genes and enhanced expression of others. The inhibitory effects of Rln cotreatment on the E2-dependent phosphorylation of ERα required the nuclear dual-specificity phosphatases DUSP1 and DUSP5. Moreover, the inhibitory effects of Rln were reflected in a concomitant inhibition of the E2-dependent contraction of myometrial cells. Collectively, our results identify a pathway that integrates Rln/RXFP1 and E2/ERα signaling, resulting in a convergence of membrane and nuclear signaling pathways to control genomic and biological outcomes.
Does Mechanism of Injury Affect Recovery After Sport-Related Concussion in Basketball? A Pilot Study
Authors: Bishay Anthony E. , Albert Avi N. , Rigney Grant H. , Corley James T. , Williams Kristen L. , Jo Jacob , Terry Douglas P. , Zuckerman Scott L. 
Published: September 2024

BACKGROUND AND OBJECTIVES:
Understanding sport-related concussion (SRC) mechanisms can aid in prevention and treatment. Concussions in basketball have received relatively less attention compared with collision sports. In a cohort of concussed high school basketball players, this pilot study sought to (1) describe the mechanisms of how concussions occur in basketball and (2) assess the relationship between mechanisms and acute symptomatology and recovery time.

METHODS:
A retrospective cohort, pilot study examined concussed adolescent athletes (aged 14-18 years) treated at a sports concussion center from 11/2017 to 04/2022. The primary independent variable was mechanism of injury, categorized into (1) contact (head-to-head, head-to-body, head-to-ball, head-to-ground), (2) player (offensive play, defensive play, both), and (3) awareness mechanisms (aware, unaware). The outcomes included acute symptom severity, time to return-to-learn, symptom resolution, and return-to-play. Associations between mechanisms and outcomes were analyzed using one-way analysis of variance, independent t-tests, multivariable linear regressions, and Cox regression.

RESULTS:
Of 105 basketball players (16.2 ± 1.4 years; 50.5% male), head-to-ground contact (n = 44/105; 41.9%) was most common. Taking-a-charge (n = 12/53; 22.6%) was the most frequent player mechanism, with similar rates for offensive (n = 24/53; 45.3%) and defensive (n = 23/53; 43.4%) plays. Most were aware of impending collision (n = 37/46; 80.4%). Head-to-body concussions were associated with higher initial symptoms severity scores when compared with head-to-head (β = 0.33, P = .003) and head-to-ground (β = 0.23, P = .050) contacts. Player and awareness mechanisms were not significant predictors of outcome measures. Only higher initial symptom scores were associated with a longer time to return-to-learn, symptom resolution, and return-to-play.

CONCLUSION:
In this pilot study of concussed high school basketball players, head-to-ground was the most common concussion mechanism, with similar rates during offensive and defensive plays. Although head-to-body contact increased acute symptoms, other mechanisms did not predict recovery time. Given the limited information on concussions in basketball, the preliminary results of this pilot study may help inform larger studies on basketball SRC mechanisms.
Metabolic ripple effects – deciphering how lipid metabolism in cancer interfaces with the tumor microenvironment
Authors: Jonker Patrick B. , Muir Alexander 
Published: September 2024

ABSTRACT
Cancer cells require a constant supply of lipids. Lipids are a diverse class of hydrophobic molecules that are essential for cellular homeostasis, growth and survival, and energy production. How tumors acquire lipids is under intensive investigation, as these mechanisms could provide attractive therapeutic targets for cancer. Cellular lipid metabolism is tightly regulated and responsive to environmental stimuli. Thus, lipid metabolism in cancer is heavily influenced by the tumor microenvironment. In this Review, we outline the mechanisms by which the tumor microenvironment determines the metabolic pathways used by tumors to acquire lipids. We also discuss emerging literature that reveals that lipid availability in the tumor microenvironment influences many metabolic pathways in cancers, including those not traditionally associated with lipid biology. Thus, metabolic changes instigated by the tumor microenvironment have ‘ripple’ effects throughout the densely interconnected metabolic network of cancer cells. Given the interconnectedness of tumor metabolism, we also discuss new tools and approaches to identify the lipid metabolic requirements of cancer cells in the tumor microenvironment and characterize how these requirements influence other aspects of tumor metabolism.
Clinical and Cardiometabolic Effects of Reducing Sedentary Behavior in Postmenopausal Women with Rheumatoid Arthritis
Authors: PINTO ANA JESSICA , MEIRELES KAMILA , PEÇANHA TIAGO , MAZZOLANI BRUNA CARUSO , SMAIRA FABIANA INFANTE , REZENDE DIEGO , BENATTI FABIANA BRAGA , DE MEDEIROS RIBEIRO ANA CRISTINA , DE SÁ PINTO ANA LÚCIA , LIMA FERNANDA RODRIGUES , ROSCHEL HAMILTON , GUALANO BRUNO 
Published: September 2024

ABSTRACT

Purpose
We investigated the effects of a 4-month intervention targeting sedentary behavior on sedentary time and physical activity level, clinical parameters, cardiometabolic risk factors, inflammatory markers, and health-related quality of life in postmenopausal women with rheumatoid arthritis.

Methods
This was a 4-month, parallel-group, randomized controlled trial (ClinicalTrials.gov identifier: NCT03186924). One hundred and three postmenopausal rheumatoid arthritis patients were randomized (1:1) to either a newly developed intervention targeting sedentary behavior (Take a STAND for Health [TS4H]) or standard of care (SOC). Sedentary behavior (primary outcome) and physical activity levels, clinical parameters, anthropometric parameters and body composition, blood samples and oral glucose tolerance test, blood pressure, muscle function, and health-related quality of life were assessed at baseline (Pre) and after 4 months (Post). Between- and within-group differences were tested using linear mixed models following the intention-to-treat principle.

Results
Total sedentary time, time in prolonged sitting bouts, standing, and stepping did not change in either group (all P ≥ 0.337). No significant between- and within-group differences were detected for any of the clinical parameters, markers of cardiometabolic health and inflammation, and health-related quality of life variables (all P ≥ 0.136). Among responders in TS4H group (those who reduced sedentary time by ≥30 min·d−1), Pre to Post IL-10 concentrations tended to reduce (group–time: P = 0.086; estimated mean difference [EMD]: −12.0 pg·mL−1 [−23.5 to −0.6], P = 0.037) and general health (group–time: P = 0.047; EMD: 10.9 A.U. [−1.1 to 22.9], P = 0.086) and overall physical health tended to improve (group–time: P = 0.067; EMD: 7.9 A.U. [−0.9 to 16.6], P = 0.089).

Conclusions
TS4H did not change sedentary behavior, physical activity levels, clinical, cardiometabolic, inflammatory, or health-related quality of life outcomes. However, TS4H tended to reduce IL-10 levels and improve health-related quality of life in responders.
Ultra-sensitive singular-phase terahertz refractive index biosensor using graphene aided Tamm plasmonic resonance and variable angle ellipsometry
Authors: Baseri Alireza , Alighanbari Abbas 
Published: September 2024

This study introduces, for the first time, to our knowledge, the development of an ultra-sensitive singular-phase refractive index biosensor based on a graphene Tamm plasmonic structure, operating at terahertz frequencies. A significant phase change occurs at the phase singularity or dark points, where surface reflection is nearly absent. Previous studies exploiting phase singularity points have involved complex techniques such as nanopatterning or integrating devices like gratings. Tamm plasmonic structures using noble metals, operating at visible light, have been studied before. The proposed structure simplifies the design by using a multilayer geometry and enhances the sensitivity using a stack of multilayer graphene, operating at 1 THz, achieving a remarkable sensitivity of 1.36×106∘/RIU in the gaseous phase, surpassing previous studies. In the liquid phase, a sensitivity of 1.05×105∘/RIU is obtained, which is higher than previous results. Such large sensitivity values are achieved by exploiting phase singularity concepts along with variable angle ellipsometry. The results are obtained using a fast and accurate transfer matrix method.
Roles of temperature, materials, and domain inversion in high-performance, low-bias-drift thin film lithium niobate blue light modulators
Authors: Celik Oguz Tolga , Yousry Ammar Nancy , Park Taewon , Stokowski Hubert S. , Multani Kevin K. S. , Hwang Alexander Y. , Gyger Samuel , Guo Yudan , Fejer Martin M. , Safavi-Naeini Amir H. 
Published: September 2024

We demonstrate a thin film lithium niobate electro-optic modulator operating at 456 nm with an RF voltage-length product of 0.38 V-cm and a bandwidth of 6.9 GHz. We test the dielectric relaxation of the modulator with sweeps of temperature and optical input power, and compare equivalent modulators with electrode materials of Cr-Au, Ti-Au and Al in terms of bias stability and current-voltage characteristics. We demonstrate bias stability over at least 8 hours with Al devices, and show relationships between drift, I-V characteristics and ferroelectric domain switching.
The influence of emotional feedback material type on attentional capture at different presentation times
Authors: Gao Jiacheng , Jia Lin , Wen Suxia , Jia Yadi , Li Guangxin , Liu Hongli 
Published: September 2024

Objective
This study aimed to explore the influence of emotional feedback materials on attentional capture at different presentation times and to investigate the mechanisms of positive and negative attentional biases.

Methods
Two experiments were conducted. Experiment 1 recruited 47 participants, and Experiment 2 recruited 46 participants. Emotional facial images and emotional words were used as feedback materials. A learning-testing paradigm was employed to explore the effect of emotional feedback materials on attentional capture at different presentation times (1000 ms/100 ms).

Results
We compared the accuracy and reaction times of participants under emotional and neutral conditions at both presentation times. Experiment 1 revealed that participants exhibited a stable positive attentional bias towards emotional facial images. Additionally, under the 100 ms feedback condition, emotional interference on judgment task accuracy was greater than under the 1000 ms feedback condition. Experiment 2 found that under the 100 ms feedback condition, emotional interference on reaction time was greater than under the 1000 ms feedback condition. Comparing the data from both experiments revealed that the processing time for emotional facial images was longer than for emotional words.

Conclusions
(1) Emotional facial images are more effective than emotional words in capturing attention. (2) When positive and negative information with equal arousal levels alternates over a period of time, individuals exhibit a stable positive attentional bias. (3) When there is intense competition for attention and cognitive resources, emotional information is prioritized for processing.
The nearshore aquatic environment of eastern Lake Erie: A thirty-year perspective from a monitoring station
Authors: Howell E.T. , Benoit N. , Stevack K. 
Published: September 2024

Abstract
Dreissenid mussels arrived at the Waverly Shoal located above the inflow of the Niagara River in 1989, initiating marked changes in the water and sediment chemistry, and benthic invertebrate community composition at an Ontario Ministry of the Environment, Conservation and Parks monitoring station. Here we examine change in the nearshore of eastern Lake Erie until 2019, inferred from monitoring at this station. Dreissenid numbers peaked in 1991, exceeding 200,000 individual m-2, and remained above 20,000 individual m-2 until 2004 after which numbers progressively declined. In 1993, the population transitioned from mixed Dreissena polymorpha and D. bugensis, to D. bugensis in subsequent years. The decrease in particle size and increase in organic content of surficial sediment which began the year after mussel arrival has persisted until present time. The low concentrations of trace metals and PAHs at the station increased slightly after the physical alteration in bed sediments and has either not changed or declined. After an initial increase in Secchi depth, water clarity changed little over post invasion years, with prevailing moderate water clarity interspersed with periods of bed resuspension and high turbidity. Calcium concentration in the water column, which fell dramatically after the arrival of dreissenids, has gradually increased in recent years. Chlorophyll a and total phosphorus levels indicating oligo-mesotrophic conditions have not varied systematically over the years, other than a modest decline in chlorophyll a after dreissenid arrival. Benthic invertebrate assemblages have gone through multiple alterations, with shifting abundance of amphipods, oligochaetes, chironomids, gastropods and sphaeriids attributed to invasive species rather than the physical environment. Collectively, the data suggests the nearshore ecosystem has shifted in benthic productivity and trophic transfers mediated by the benthos and invasive species, with water and sediment quality appearing to not vary beyond the range driven by inherently fluctuating physical conditions.
Broad scale community-level larval fish survey of southern Lake Erie
Authors: DeBruyne R.L. , Amidon Z.A. , Angelosanto M. , Eberly E. , Gorsky D. , Ireland S.A. , Mayer C.M. , Provo S. , VanScoyoc H. , Watkins J.M. , Roseman E.F. 
Published: September 2024

Abstract
The early-life history stages of fish are sensitive to environmental change and therefore can indicate habitat quality as well as help predict recruitment of resident and transient fishes. In 2019, as part of the Lake Erie Cooperative Science and Monitoring Initiative, we conducted a lake-wide assessment of the ichthyoplankton community in U.S. nearshore waters and international offshore waters. The goal of this work was to characterize the larval fish community across the lake and assess species composition, phenology, and distribution of larvae. Ichthyoplankton were sampled weekly using bongo nets at ports beginning at the Detroit River and along the southern shore of Lake Erie to Dunkirk, NY, and less frequently in the Niagara River and offshore areas. Larval fish were present from March 26 through August 29, 2019. The first taxon to emerge was Lake Whitefish in all basins, followed by Walleye, Yellow Perch, and catostomids, depending on port. Mean total density peaked in mid-June due to high catches of Gizzard Shad, Morone spp., and Freshwater Drum in the western basin. Few fish were collected in the offshore sites. Taxa richness, diversity, and larval density were higher in the western basin and lower in the central and eastern basins, generally following the productivity gradient. This was the first study to provide a comprehensive community assessment of the ichthyoplankton community of Lake Erie and can provide a baseline to assess future change, especially in community composition or phenology, of larvae which are likely to respond to climate and habitat change.
Finite simple permutation groups acting with fixity 4
Authors: Baumeister Barbara , Hähndel Paula , Magaard Kay , Salfeld Patrick , Waldecker Rebecca 
Published: September 2024

Abstract
Motivated by the theory of Riemann surfaces and specifically the significance of Weierstrass points, we classify all finite simple groups that have a faithful transitive action with fixity 4.
We also give details about all possible such actions.
On the number of tuples of group elements satisfying a first-order formula
Authors: Brusyanskaya Elena K. 
Published: September 2024

Abstract
Our result contains as special cases the Frobenius theorem (1895) on the number of solutions to the equation

x
n

=
1

x^{n}=1

in a finite group and the Solomon theorem (1969) on the number of solutions in a group to systems of equations with fewer equations than unknowns.
Instead of systems of equations, we consider arbitrary first-order formulae in the group language with constants.
Our result substantially generalizes the Klyachko–Mkrtchyan theorem (2014) on this topic.
Purity and hybridness of two tensors on a real hypersurface in complex projective space
Authors: Pérez Juan de Dios , Pérez-López David 
Published: September 2024

Abstract
On a real hypersurface

M

M

in complex projective space, we can define two tensor fields of type (1, 2),

A

F

(

k

)

{A}_{F}^{\left(k)}

and

A

T

(

k

)

{A}_{T}^{\left(k)}

, associated with the shape operator

A

A

of the real hypersurface, for any nonnull real number

k

k

. Following Tachibana [Analytic tensor and its generalization, Tohoku Math. J. 12 (1960), 208–221], we study the purity and hybridness of such tensors with respect to

A

A

.
Orbital magnetism through inverse Faraday effect in metal clusters
Authors: Lian Deru , Yang Yanji , Manfredi Giovanni , Hervieux Paul-Antoine , Sinha-Roy Rajarshi 
Published: September 2024

Abstract
In view of the recent increased interest in light-induced manipulation of magnetism in nanometric length scales this work presents metal clusters as promising elementary units for generating all-optical ultrafast magnetization. We perform a theoretical study of the opto-magnetic properties of metal clusters through ab-initio real-time (RT) simulations in real-space using time-dependent density functional theory (TDDFT). Through ab-initio calculations of plasmon excitation with circularly polarized laser pulse in atomically precise clusters of simple and noble metals, we discuss the generation of orbital magnetic moments due to the transfer of angular momentum from light field through optical absorption at resonance energies. Notably, in the near-field analysis we observe self-sustained circular motion of the induced electron density corroborating the presence of nanometric current loops which give rise to orbital magnetic moments due to the inverse Faraday effect (IFE) in the clusters. The results provide valuable insights into the quantum many-body effects that influence the IFE-mediated light-induced orbital magnetism in metal clusters depending on its geometry and chemical composition. At the same time, they explicitly demonstrate the possibility for harnessing magnetization in metal clusters, offering potential applications in the field of all-optical manipulation of magnetism.