bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of different antiseptics on umbilical cord colonization and cord separation time
Authors: Ozdemir Hulya , Bilgen Hulya , Topuzoglu Ahmet , Coskun Senay , Soyletir Guner , Bakir Mustafa , Ozek Eren 
Published: March 2017

Introduction: There is still some uncertainty on cord care practices all around the world, especially in developing countries. The aim of our study was to investigate the effects of six different umbilical cord care practices on the rate of colonization and cord separation time. Methodology: A total of 516 newborns were randomly allocated to the following six umbilical cord care groups: group 1 received dry care; groups 2–4 received a single application of 70% alcohol, 4% chlorhexidine, or povidon-iodine in the delivery room, respectively, which were discontinued thereafter; groups 5 and 6 received a single application of 70% alcohol or 4% chlorhexidine, respectively, starting in the delivery room and continuing every six hours until discharge. Umbilical cords were examined on the second and third days and between the fifth and seventh day for signs of omphalitis. Swab cultures were taken on the second or third day from all cases. Results: Cord separation time (median [interquartile range]) was the shortest for group 1 (7 [6–7] days) and the longest for group 3 (10 [7–12] days) and group 6 (10 [8–12] days) (p < 0.001). The cord colonization in the swab cultures was significantly lower in groups 3 and 6 (p < 0.001). Omphalitis was detected in eight (1.5%) patients among the study population, and there was no significant difference between the groups. Conclusions: Our study showed that chlorhexidine application was the most effective agent in decreasing colonization, though it increased cord separation time significantly in both groups.
Definition and Reliability Assessment of Elementary Ultrasonographic Findings in Calcium Pyrophosphate Deposition Disease: A Study by the OMERACT Calcium Pyrophosphate Deposition Disease Ultrasound Subtask Force
Authors: Filippou Georgios , Scirè Carlo A. , Damjanov Nemanja , Adinolfi Antonella , Carrara Greta , Picerno Valentina , Toscano Carmela , Bruyn George A. , D’Agostino Maria Antonietta , Delle Sedie Andrea , Filippucci Emilio , Gutierrez Marwin , Micu Mihaela , Möller Ingrid , Naredo Esperanza , Pineda Carlos , Porta Francesco , Schmidt Wolfgang A. , Terslev Lene , Vlad Violeta , Zufferey Pascal , Iagnocco Annamaria 
Published: March 2017

Objective.To define the ultrasonographic characteristics of calcium pyrophosphate crystal (CPP) deposits in joints and periarticular tissues and to evaluate the intra- and interobserver reliability of expert ultrasonographers in the assessment of CPP deposition disease (CPPD) according to the new definitions.Methods.After a systematic literature review, a Delphi survey was circulated among a group of expert ultrasonographers, who were members of the CPPD Ultrasound (US) Outcome Measures in Rheumatology (OMERACT) subtask force, to obtain definitions of the US characteristics of CPPD at the level of fibrocartilage (FC), hyaline cartilage (HC), tendon, and synovial fluid (SF). Subsequently, the reliability of US in assessing CPPD at knee and wrist levels according to the agreed definitions was tested in static images and in patients with CPPD. Cohen’s κ was used for statistical analysis.Results.HC and FC of the knee yielded the highest interobserver κ values among all the structures examined, in both the Web-based (0.73 for HC and 0.58 for FC) and patient-based exercises (0.55 for the HC and 0.64 for the FC). Kappa values for the other structures were lower, ranging from 0.28 in tendons to 0.50 in SF in the static exercise and from 0.09 (proximal patellar tendon) to 0.27 (triangular FC of the wrist) in the patient-based exercise.Conclusion.The new OMERACT definitions for the US identification of CPPD proved to be reliable at the level of the HC and FC of the knee. Further studies are needed to better define the US characteristics of CPPD and optimize the scanning technique in other anatomical sites.
Whole-spine Computed Tomography Findings in SAPHO Syndrome
Authors: Xu Wenrui , Li Chen , Zhao Xue , Lu Jie , Li Li , Wu Nan , Zuo Yuzhi , Jing Hongli , Dong Zhenhua , Zhang Wen , Zhang Weihong 
Published: March 2017

Objective.We evaluated the whole-spine computed tomography (CT) findings in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome to improve our understanding of this rare disease.Methods.Whole-spine CT images obtained in 69 patients with SAPHO were reviewed. For each individual, a total of 25 vertebrae were evaluated for the distribution of affected vertebrae, CT manifestations of vertebral lesions, symmetry and location of distribution of the lesions on vertebrae, involvement pattern, and narrowing of adjacent intervertebral disc space. Paravertebral ligamentous ossifications, apophyseal joint disorders, and costovertebral joint disorders were also evaluated.Results.All the 69 patients with SAPHO exhibited abnormalities on whole-spine CT. Sixty-four had vertebral lesions, 52 had paravertebral ossifications, and 47 had both. The vertebral lesions were observed in 441 vertebrae, with a predilection for thoracic spine. The lesions exhibited a mixture of cortical erosion, reactive osteosclerosis of surrounding cancellous bone, and syndesmophyte. They may be confined to the vertebral corner (65.1%) or be extensive, involving the endplate (34.9%). Corner lesions could start in any part of the epiphyseal ring. The lesions were asymmetrically distributed. The affected vertebrae were more consecutively involved in a “kissing” appearance (78.2%). Intervertebral disc spaces were usually normal or mildly narrowed. There were 320 foci of paravertebral ossifications observed, with a predilection for the supraspinous ligament. Paravertebral ossifications were delicate and segmental. Ossifications throughout annulus fibrosis and apophyseal joint were not observed.Conclusion.Our investigation of the distributional, morphological features and the involvement pattern of spinal lesions in patients with SAPHO demonstrated distinct CT characteristics.
L’analyste au risque de la dualité pulsionnelle
Authors: Dudaczyk Delphine , Hussmann Agnès 
Published: March 2017

Face à la butée d’un mouvement répétitif qui s’opère dans une relation thérapeutique et face à une chute dépressive vertigineuse, deux psychologues viennent questionner leur pratique et certains enjeux transférentiels. L’intérêt de cet article écrit à deux voix réside dans la tentative de compréhension de ces temps au cours desquels l’activité symbolique semble s’être figée, en s’appuyant sur des théorisations psychanalytiques. Il considère en outre la pulsionnalité à l’œuvre, notamment dans la résurgence de la pulsion de vie sollicitée par le thérapeute, mais aussi dans son essence : celle-ci relèverait-elle de la créativité ?
L’art thérapie interroge la créativité
Authors: Grignoli Laura 
Published: March 2017

Dans cet article, nous aborderons la créativité à travers une méthode de soins qui utilise l’art pour exprimer ce qui se cache dans l’inconscient. Le code linguistique privilégié de l’inconscient est sans aucun doute celui du rêve, mais aussi celui de l’art. L’art devient expression symbolique des sentiments humains. Il permet d’extérioriser des vécus non-verbalisables contenus dans la psyché, qui ont une origine très ancienne et profonde. La vie intérieure, qui ne peut pas être atteinte par la pensée discursive, comme les expériences corporelles de la phase pré-verbale, peut être contactée par la voie de l’art. Le patient qui se dévoile dans l’œuvre n’est pas conscient mais le processus amorce une transformation (trans-forme-action) personnelle. Substance et forme résident encore « dedans ». Nous évoquerons aussi un cas clinique, un homme soigné par l’art thérapie.
Je sais pas dessiner
Authors: de Wailly Florence 
Published: March 2017

En parlant de créativité, Winnicott nous rappelle « que le monde de nos perceptions est lettre morte tant qu’il n’est pas animé par un regard ». Comment les enfants ayant vécu l’abandon et la carence de soins à un âge précoce et pendant une durée importante peuvent-ils accéder à l’illusion, préalable incontournable de l’accès à l’espace transitionnel ? Peuvent-ils faire preuve de créativité dans un espace de jeu situé entre la réalité et le fantasme et peut-on les y aider au cours d’une cure psychanalytique ?
L’imaginaire érotique en séance
Authors: Fabre Nicole 
Published: March 2017

Nous définirons en premier lieu l’imaginaire en nous référant à Gaston Bachelard ; et l’érotique comme ce qui, plutôt que de chercher à assouvir le désir, vise à créer le désir chez l’autre et l’excitation en soi-même. Puis nous aborderons l’imaginaire érotique tel qu’il s’est développé dans deux cures. Dans un premier fragment nous assistons à l’émergence du refoulé et au renouvellement de la vie grâce à un rêve-éveillé en séance où l’imaginaire érotique a joué un rôle essentiel. Dans un deuxième fragment nous verrons comment le jeu du transfert pris en charge par le rêve-éveillé sur un mode fortement érotisé a restitué au patient sa capacité de désir.
Evolution du couple et de sa sexualité
Authors: Brenot Philippe 
Published: March 2017

La notion de couple est extrêmement récente, elle date des 50 dernières années. Auparavant, on parlait d’un mariage ou d’un jeune ménage lorsqu’il venait de se former. Le couple est aujourd’hui l’association de deux sujets désirants, cela implique donc que chaque membre du couple soit déjà un sujet. Notre formation psychothérapique nous permet d’estimer cette première étape – chaque membre est-il un sujet - avant que ne puisse se constituer la dyade « couple » qui nécessite encore une habileté, sinon une expérience, dans sa construction. Cela va à l’encontre de la conception traditionnelle du mariage instauré pour la vie entière. L’impératif actuel de la dimension sexuelle, sinon érotique, complique encore cette construction psycho-sociale qu’est le couple.
Les animaux dans les villes de l’Égypte lagide
Authors: Gerardin François 
Published: March 2017

Prenant pour point de départ l’anecdote, relatée par Diodore, du meurtre d’un chat par un Romain à Alexandrie et du lynchage de celui-ci par la foule, cet article évalue la place de l’animal dans les villes de l’Egypte lagide (cités grecques, capitales des régions administratives appelés nomes et bourgs du Fayoum). Chaque catégorie animale – animaux sacrés, animaux voués à la production, animaux de prestige et d’agrément – occupe l’espace urbain à sa façon propre, en vertu de dynamiques religieuses, économiques, ou sociales. L’animal était omniprésent dans le milieu urbain égyptien pharaonique (c’est la « symbiose » entre le monde animal et égyptien propre à cette civilisation). Sa présence a été encore renforcée, et selon de modalités nouvelles, par l’implantation du régime monarchique lagide, qui fait de l’animal un élément d’affirmation symbolique de son pouvoir ainsi que d’accroissement de la richesse agricole de l’Egypte.
Bouchers et boucherie à Paris
Authors: Piette Christine 
Published: March 2017

Le commerce de la boucherie à Paris subit, au cours de la première moitié du XIX e siècle, une mutation majeure qui voit son statut passer de celui d’un monopole étroitement réglementé à celui d’un commerce libre, en accord avec le mouvement général de l’économie. Ce changement ne s’est pas fait sans douleur du côté des bouchers, ni dans sans débats du côté de leurs opposants. Cet article examine d’abord l’argumentation des bouchers ; il passe ensuite en revue les arguments des adversaires du monopole. Nous croyons, et c’est là l’objet de la dernière partie de l’article, qu’aucune de ces parties ne pose le véritable problème auquel le commerce de la boucherie était confronté. En effet, le problème majeur qui affecte ce commerce est celui de la transformation complète qui s ’ opère dans la pratique du métier de boucher et dans les tensions intrinsèques qui s ’ en suivent.
Esquisse d’une métapsychologie de l’identité
Authors: Drweski Philippe 
Published: March 2017

Dans cet article, l’auteur part du constat que malgré la multiplication des échanges qu’implique notre modernité, certains conflits demeurent. Pour comprendre ce phénomène, l’auteur s’intéresse à la dimension identitaire chez des sujets expatriés. Cette analyse permet de souligner que ce processus identitaire concerne plusieurs niveaux psychiques : celui du narcissisme, des enveloppes psychiques et enfin des liens identificatoires. Chacun de ces niveaux est ainsi touché lors des différentes étapes de l’expatriation. Nous observons que l’identité oscille entre deux axes antagonistes. D’une part un repli identitaire dont le but est la préservation narcissique ou bien, à l’opposé une renonciation identitaire comme tentative d’intégration à l’environnement au risque d’un anéantissement de l’identité du sujet. Cette étude permet ainsi de mieux comprendre les enjeux et les crises psychiques que révèlent les nouvelles formes de mondialisation.
Stress and Coping of Critical Care Nurses After Unsuccessful Cardiopulmonary Resuscitation
Authors: McMeekin Dawn E. , Hickman Ronald L. , Douglas Sara L. , Kelley Carol G. 
Published: March 2017

BackgroundParticipation by a critical care nurse in an unsuccessful resuscitation can create a unique heightened level of psychological stress referred to as postcode stress, activation of coping behaviors, and symptoms of posttraumatic stress disorder (PTSD).ObjectivesTo explore the relationships among postcode stress, coping behaviors, and PTSD symptom severity in critical care nurses after experiencing unsuccessful cardiopulmonary resuscitations and to see whether institutional support attenuates these repeated psychological traumas.MethodsA national sample of 490 critical care nurses was recruited from the American Association of Critical-Care Nurses’ eNewsline and social media. Participants completed the Post-Code Stress Scale, the Brief COPE (abbreviated), and the Impact of Event Scale–Revised, which were administered through an online survey.ResultsPostcode stress and PTSD symptom severity were weakly associated (r = 0.20, P = .01). No significant associations between coping behaviors and postcode stress were found. Four coping behaviors (denial, self-distraction, self-blame, and behavioral disengagement) were significant predictors of PTSD symptom severity. Severity of postcode stress and PTSD symptoms varied with the availability of institutional support.ConclusionsCritical care nurses show moderate levels of postcode stress and PTSD symptoms when asked to recall an unsuccessful resuscitation and the coping behaviors used. Identifying the critical care nurses most at risk for PTSD will inform the development of interventional research to promote critical care nurses’ psychological well-being and reduce their attrition from the profession.
Electronic Alerts Improve Immunization Rates in Two-month-old Premature Infants Hospitalized in the Neonatal Intensive Care Unit
Authors: Ernst Kimberly 
Published: March 2017

Summary
Objective: To determine if an electronic alert improves 2 month immunization rates in infants remaining hospitalized in the neonatal intensive care unit.
Methods: Institutional Review Board-approved retrospective chart review of 261 infants with birth weights <2 kg and still hospitalized at58 days. Charts were reviewed between 2009 and 2013, before and after the 2011 electronic alert was instituted in the electronic medical record from days 56 to 67 to remind providers that immunizations were due. Order and administration dates of two-month vaccine components (Diphtheria, Haemophilus influenza B, Hepatitis B Pertussis, Pneumococcal, Polio, Tetanus) were determined, and infants were considered fully immunized, partially immunized, or unimmunized by day 90 or discharge, whichever came first.
Results: After the alert, the timing of vaccine orders decreased from day 67 to day 61 (p<0.0001) and vaccine administration decreased from day 71 to day 64 (p<0.0001). Missing vaccine orders decreased from 14% [17/121] to 3% [4/140] (p=0.001) with missing administrations decreasing from 21% [26/121] to 4% [6/140] (p<0.0001). Fully immunized rates increased from 71% [86/121] to 94% [132/140] (p<0.0001).
Conclusions: A significant improvement in immunization rates in two-month-old infants in the neonatal intensive care unit occurred by 90 days after implementing an alert in the electronic medical record.
3D printing of beta-amyloid protein deposits along capillary walls
Authors: Blue China , Horowitz Seth S. , Snyder Peter J. 
Published: March 2017

Abnormally high levels of neocortical beta-amyloid protein (A+) reflect Alzheimer’s disease (AD) pathology in persons with clinical evidence of dementia or mild cognitive impairment (MCI). The abnormal aggregation of beta-amyloid protein in the brain neuropil may lead to either diffuse plaques and/or concentrated neuritic plaques, with the latter form of deposits often present in the vicinity of the cerebral microvasculature. The A protein, with its crystalline molecular structure, infiltrates the vessel walls and compromises the blood-brain barrier (BBB). The physical basis for this was elegantly shown by Meyer and colleagues, in a 2008 publication showing two-dimensional (2D) confocal laser scanning microscopic imaging of vascular A protein deposits in APP23 transgenic mice. These investigators showed accumulations of “tuft-life structures”, also referred to as “pompons” with protruding spikes on – and embedded within – microvessels. These pompons of beta-amyloid protein “consist of fibrillar structures, [and] can encircle and constrict capillaries, and are often associated with distortion of capillaries”.We were struck by both the heuristic value of the imaging of Meyer and colleagues, in explaining the root cause of both the amyloid-related alterations in the vascular bed, and depicting minute protein deposits that are both geometrically complex, seemingly delicate and fragile, and yet tenacious in their embedding within small vessel walls. We re-created these images with standard 3D printing technology (extruded plastic) for both educational/teaching and artistic purposes.
SP174, NRAS Q61R Mutant-Specific Antibody, Cross-Reacts With KRAS Q61R Mutant Protein in Colorectal Carcinoma
Authors: Lasota Jerzy , Kowalik Artur , Felisiak-Golabek Anna , Inaguma Shingo , Wang Zeng-Feng , Pięciak Liliana , Zięba Sebastian , Pęksa Rafał , Kopczynski Janusz , Okoń Krzysztof , Waloszczyk Piotr , Gozdz Stanislaw , Biernat Wojciech , Miettinen Markku 
Published: March 2017

Context.—
NRAS is a member of the RAS family oncoproteins implicated in cancer. Gain-of-function NRAS mutations were reported in a subset of colorectal cancers. These mutations occur at codons 12, 13, and 61 and are detected by molecular genetic testing. Recently, an antibody (clone SP174) became available to immunohistochemically pinpoint NRAS Q61R mutant protein. In malignant melanoma, NRAS Q61R mutant–specific immunohistochemistry was shown to be a valuable supplement to traditional genetic testing.

Objective.—
To evaluate the significance of NRAS Q61R mutant–specific immunohistochemistry in a cohort of colorectal carcinomas.

Design.—
A total of 1185 colorectal carcinomas were immunohistochemically evaluated with SP174 antibody. NRAS Q61R mutant–specific immunohistochemistry was validated by molecular genetic testing including Sanger sequencing, quantitative polymerase chain reaction (qPCR), and next-generation sequencing.

Results.—
Twelve tumors showed strong SP174 immunoreactivity. Sanger sequencing detected an identical c.182A&gt;G substitution, causing NRAS Q61R mutation at the protein level, only in 8 SP174-positive cases. These results were confirmed by qPCR study. Subsequently, NRAS wild-type tumors with strong SP174 staining were evaluated by next-generation sequencing and revealed KRAS c.182A&gt;G substitutions predicted to cause KRAS Q61R mutation. Review of colorectal carcinomas with known KRAS and NRAS genotype revealed that none of 62 wild-type tumors or 47 mutants other than Q61R were SP174 positive.

Conclusion.—
SP174 immunohistochemistry allows sensitive detection of NRAS and KRAS Q61R mutants. However, molecular genetic testing is necessary to determine specifically which RAS gene is mutated.
The Influence of MUET Score and First Language towards English as a Second (ESL) Learners’ Self-Confidence
Authors: Kahiruddin Zulaikha 
Published: March 2017

Speaking skill is an important skill among the four English skills and it is also known as expressive skill. Hence, it is important for students to speak in English confidently and using speaking strategies in order to avoid anxiousness. The two objectives of this study are to identify level of confidence when speaking among Law students and to determine if there is any significant difference in level of confidence when speaking among Law students based on their demographic details (MUET result, first language) respectively. This study employed a purely quantitative study. The instrument used in this study was questionnaire and 380 respondents which consisted of Law students from four local universities in Malaysia) participated in this study The result from this study indicated the level of self-confidence among Law students was above average and it was also portrayed that there was a significant difference in terms of Law students’ level of self-confidence based on their MUET result and first language correspondingly. Thus, from the results of the study, it is recommended for the stakeholders which are lecturers, the Faculty of Law, the universities and the policy maker to develop more authentic materials and environment for the students.
Venous thromboembolism following initiation of atypical antipsychotics in two geriatric patients
Authors: Maestri Thomas J. , Koenig Jessica , Masuda Christine , Smith Tawny L. , Garcia-Pittman Erica C. 
Published: March 2017

Abstract

Background:
Although not formally highlighted as a risk factor in current practice guidelines, several observational studies have reported a possible association between antipsychotic use and development of venous thromboembolism (VTE). However, it is unclear to what extent the risk is elevated.

Case Report:
Described are 2 cases of VTE following recent initiation of second-generation antipsychotics in elderly patients. Ms A was a 65-year-old woman with newly diagnosed bipolar I disorder who was hospitalized for acute mania and psychosis. She was treated with risperidone along with traditional mood stabilizers and developed a pulmonary embolism shortly after treatment initiation. Ms B was a 77-year-old woman with newly diagnosed bipolar I disorder who was hospitalized for depression and psychosis. She was treated with quetiapine and electroconvulsive therapy and developed a pulmonary embolism and deep vein thrombosis within 2 months of starting treatment. Risk assessment tools were not able to definitively predict the VTEs that developed in our patients.

Conclusion:
The association between antipsychotic medication and VTE has shown the highest risk with atypical antipsychotics, high dosages, and initiation within the past 3 months. Risk assessment tools may assist in assessing the risk of VTE in patients on antipsychotic therapy, although patients who are deemed by these tools to have minimal risk can still develop a VTE. Discussing VTE risk with patients when considering antipsychotic usage may help clinicians and patients safely determine the most appropriate treatment for their psychiatric illnesses while mitigating potential adverse effects.