bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rādhāvallabha
Authors: Beck Guy 
Published: July 2016

The name “Rādhāvallabha” (Rādhā-vallabha) in Sanskrit refers to the Hindu god Krishna, who is known as the lover of Rādhā, his eternal divine consort. This epithet combines “Rādhā” with “vallabha” to signify “Dearest of Rādhā.” Most Hindu gods and goddesses possess multiple epithets that relate to their images, associations, or divine pastimes. The name of Rādhāvallabha also refers to a Vaishnava lineage and community known as the Rādhāvallabha Sampradāya (Rādhāvallabha “lineage” or “tradition”) that is part of the Bhakti movement. Differing from other Vaishnava denominations that place Krishna as the central divinity, the Rādhāvallabha Sampradāya places the deity of Rādhā as primary in the theological hierarchy. The sect also withdraws from traditional Sanskrit scholarship and Vaishnava preoccupations in favor of a simple yet exclusive devotion to Rādhā and Krishna with literary expression primarily in the vernacular. The Rādhāvallabha Sampradāya was founded in c. 1535 ce by the poet-saint Hita Harivaṁśa (1502–1552 ce) in Vrindāban (cf. Vrindāvan, Vrindāvana), the small forest area in Braj near Gokula where Krishna is believed to have spent his childhood some 5,000 years ago. Harivaṁśa established the worship of the deity of Rādhāvallabha in a grove near the Yamunā River in Vrindāban in c. 1545 ce. Hita Harivaṁśa’s principal work in Braj Bhasha (a dialect of Hindi) is the Caurāsi-Pada, consisting of eighty-four verses describing the erotic love pastimes of Rādhā and Krishna. There is also a work in Sanskrit glorifying Rādhā as supreme. Additional poet-saints contributed to what became an extremely rich corpus of song-texts composed for singing in Rādhāvallabha worship. The Sevā or worship consists of daily routines of offerings and seasonal festivals. The songs or hymns are sung in the style of Samāj-Gāyan, a special interactive manner of vocal music that is unique to Braj yet related to Dhrupad, a form of early Hindustani music. The main temple is crowded during festivals like Holi and Annakut. Still a vibrant living tradition, the beautiful style of musical worship and veneration of Krishna as Rādhāvallabha is one of the treasures of the Bhakti tradition. Areas not represented here and still in need of research include the growth of the religious community, the history of the various temples both in Braj and in India including Rajasthan and Calcutta, records of patronage from local and regional business interests, and issues of gender and class structure involving disciples and lay followers.
On the independent loci assumption in phylogenomic studies
Authors: Jennings W. Bryan 
Published: July 2016

AbstractStudies using multi-locus coalescent methods to infer species trees or historical demographic parameters usually require the assumption that the gene tree for each locus (or SNP) is genealogically independent from the gene trees of other sampled loci. In practice, however, researchers have used two different criteria to delimit independent loci in phylogenomic studies. The first criterion, which directly addresses the condition of genealogical independence of sampled loci, considers the long-term effects of homologous recombination and effective population size on linkage between two loci. In contrast, the second criterion, which only considers the single-generation effects of recombination in the meioses of individuals, identifies sampled loci as being independent of each other if they undergo Mendelian independent assortment. Methods that use these criteria to estimate the number of independent loci per genome as well as intra-chromosomal “distance thresholds” that can be used to delimit independent loci in phylogenomic datasets are reviewed. To compare the efficacy of each criterion, they are applied to two species (an invertebrate and vertebrate) for which relevant genetic and genomic data are available. Although the independent assortment criterion is relatively easy to apply, the results of this study show that it is overly conservative and therefore its use would unfairly restrict the sizes of phylogenomic datasets. It is therefore recommended that researchers only refer togenealogicallyindependent loci when discussing the independent loci assumption in phylogenomics and avoid using terms that may conflate this assumption with independent assortment. Moreover, whenever feasible, researchers should use methods for delimiting putatively independent loci that take into account both homologous recombination and effective population size (i.e., long-term effective recombination).
Waves of chromatin modifications in mouse dendritic cells in response to LPS stimulation
Authors: Vandenbon Alexis , Kumagai Yutaro , Suzuki Yutaka , Nakai Kenta 
Published: July 2016

AbstractBackgroundThe importance of transcription factors (TFs) and epigenetic modifications in the control of gene expression is widely accepted. However, causal relationships between changes in TF binding, histone modifications, and gene expression during the response to extracellular stimuli are not well understood. Here, we analyzed the ordering of these events on a genome-wide scale in dendritic cells (DCs) in response to lipopolysaccharide (LPS) stimulation.ResultsUsing a ChIP-seq time series dataset, we found that the LPS-induced accumulation of different histone modifications follow clearly distinct patterns. Increases in H3K4me3 appear to coincide with transcriptional activation. In contrast, H3K9K14ac accumulates early after stimulation, and H3K36me3 at later time points. Integrative analysis with TF binding data revealed potential links between TF activation and dynamics in histone modifications. Especially, LPS-induced increases in H3K9K14ac and H3K4me3 were associated with binding by STAT1/2, and were severely impaired inStat1-/-cells.ConclusionsWhile the timing of short-term changes of some histone modifications coincides with changes in transcriptional activity, this is not the case for others. In the latter case, dynamics in modifications more likely reflect strict regulation by stimulus-induced TFs, and their interactions with chromatin modifiers.
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations
Authors: Brammeld Jonathan S. , Petljak Mia , Martincorena Inigo , Williams Steven P. , Garcia Alonso Luz , Dalmases Alba , Bellosillo Beatriz , Robles-Espinoza Carla Daniela , Price Stacey , Barthorpe Syd , Tarpey Patrick , Alifrangis Constantine , Bignell Graham , Vidal Joana , Young Jamie , Stebbings Lucy , Beal Kathryn , Stratton Michael R , Saez-Rodriguez Julio , Garnett Mathew , Montagut Clara , Iorio Francesco , McDermott Ultan 
Published: July 2016

AbstractDrug resistance is an almost inevitable consequence of cancer therapy and ultimately proves fatal for the majority of patients. In many cases this is the consequence of specific gene mutations that have the potential to be targeted to re-sensitize the tumor. The ability to uniformly saturate the genome with point mutations without chromosome or nucleotide sequence context bias would open the door to identify all putative drug resistance mutations in cancer models. Here we describe such a method for elucidating drug resistance mechanisms using genome-wide chemical mutagenesis allied to next-generation sequencing. We show that chemically mutagenizing the genome of cancer cells dramatically increases the number of drug-resistant clones and allows the detection of both known and novel drug resistance mutations. We have developed an efficient computational process that allows for the rapid identification of involved pathways and druggable targets. Such a priori knowledge would greatly empower serial monitoring strategies for drug resistance in the clinic as well as the development of trials for drug resistant patients.
Cytomegalovirus Antigenic Mimicry of Human Alloreactive Peptides: A Potential Trigger for Graft versus Host Disease
Authors: Hall Charles , Koparde Vishal , Jameson-Lee Max , Elnasseh Abdelrhman , Scalora Allison , Kobulnicky Jared , Serrano Myrna , Roberts Catherine , Buck Gregory , Neale Micheal , Nixon Daniel , Toor Amir 
Published: July 2016

AbstractThe association between human cytomegalovirus (hCMV) reactivation and the development of graft-versus-host-disease (GVHD) has been observed in stem cell transplantation (SCT). Seventy seven SCT donor-recipient pairs (DRP) (HLA matched unrelated donor (MUD), n=50; matched related donor (MRD), n=27) underwent whole exome sequencing to identify single nucleotide polymorphisms (SNPs) generating alloreactive peptide libraries for each DRP (9-mer peptide-HLA complexes); Human CMV CROSS (Cross-Reactive Open Source Sequence) Database was compiled from NCBI; HLA class I binding affinity for each DRPs HLA was calculated by NetMHCpan 2.8 and hCMV-derived 9-mers algorithmically compared to the alloreactive peptide-HLA complex libraries. Short consecutive (≥6) amino acid (AA) sequence homology matching hCMV to recipient peptides was considered for HLA-bound-peptide (IC50<500nM) cross reactivity. Of the 70,686 hCMV 9-mers contained within the hCMV CROSS database, 29,658.8 ± 9038.5 were found to match MRD DRP alloreactive peptides and 52,910.2 ± 16121.8 matched MUD DRP peptides (Student’s T-test, p<0.001).In silicoanalysis revealed multiple high affinity, immunogenic CMV-Human peptide matches (IC50<500 nM) expressed in GVHD-affected tissue-specific manner (proteins expressed at ≥10 RPKM). hCMV+GVHD was found in 18 patients, 13 developing hCMV viremia before GVHD onset with a subset analysis of 7 instances of hCMV viremia prior to acute GVHD onset (n=3), chronic GVHD (n=2) and acute + chronic GVHD (n=2) indicating cross reactive peptide expression within affected organs. We propose that based on our analysis and preliminary clinical correlations that hCMV immune cross-reactivity may cause antigenic mimicry of human alloreactive peptides triggering GVHD.
Sensitivity in binding free energies due to protein reorganization
Authors: Lim Nathan M. , Wang Lingle , Abel Robert , Mobley David L. 
Published: July 2016

AbstractTremendous recent improvements in computer hardware, coupled with advances in sampling techniques and force fields, are now allowing protein-ligand binding free energy calculations to be routinely used to aid pharmaceutical drug discovery projects. However, despite these recent innovations, there are still needs for further improvement in sampling algorithms to more adequately sample protein motion relevant to protein-ligand binding. Here, we report our work identifying and studying such clear and remaining needs in the apolar cavity of T4 Lysozyme L99A. In this study, we model recent experimental results that show the progressive opening of the binding pocket in response to a series of homologous ligands.1Even while using enhanced sampling techniques, we demonstrate that the predicted relative binding free energies (RBFE) are sensitive to the initial protein conformational state. Particularly, we highlight the importance of sufficient sampling of protein conformational changes and demonstrate how inclusion of three key protein residues in the ‘hot’ region of the FEP/REST simulation improves the sampling and resolves this sensitivity.
Oversatiation negatively affects evaluation of goal-relevant (but not goal-irrelevant) advertised brands
Authors: Karremans Johan C. , Kacha Mathieu , Herrmann Jean-Luc , Vermeulen Christophe , Corneille Olivier 
Published: July 2016

Purpose
The purpose of the present paper is to examine the effects of overconsumption on consumer evaluations of advertised brands. While the determinants and health consequences of overconsumption have received considerable attention, the authors suggest that there are important marketing and advertising implications. Specifically, based on goal theory, the authors examined whether the aversive state of oversatiation is associated with more negative evaluations of advertised brands of the overconsumed product.

Design/methodology/approach
In three studies, oversatiation was measured or experimentally induced by having participants drink (too) much mineral water. Subsequently, participants watched advertisement of mineral water brands and control brands. Evaluations of the brands, buying intentions and estimates of future purchases of the advertised brands were measured.

Findings
Oversatiation negatively affected evaluations, buying intentions and estimates of future purchases of advertised mineral water brands. Importantly, a state of oversatiation did not affect evaluation of advertised brands not relevant to the overfulfilled goal.

Originality/value
Overconsumption of food and drinks can have detrimental health effects and results in large costs to society. While its health implications have received abundant scientific attention, little attention has been paid to the psychological consequences of the state of being oversatiated. Here, the authors show that the state of oversatiation (which might, for example, be very common during watching television commercials) can lead to particularly negative evaluations of advertised brands. As such, these findings have important marketing implications.
Public participation in decision-making on the coverage of new antivirals for hepatitis C
Authors: Kieslich Katharina , Ahn Jeonghoon , Badano Gabriele , Chalkidou Kalipso , Cubillos Leonardo , Hauegen Renata Curi , Henshall Chris , Krubiner Carleigh B , Littlejohns Peter , Lu Lanting , Pearson Steven D , Rid Annette , Whitty Jennifer A , Wilson James 
Published: July 2016

Purpose
– New hepatitis C medicines such as sofosbuvir underline the need to balance considerations of innovation, clinical evidence, budget impact and equity in health priority-setting. The purpose of this paper is to examine the role of public participation in addressing these considerations.

Design/methodology/approach
– The paper employs a comparative case study approach. It explores the experience of four countries – Brazil, England, South Korea and the USA – in making coverage decisions about the antiviral sofosbuvir and involving the public and patients in these decision-making processes.

Findings
– Issues emerging from public participation ac tivities include the role of the universal right to health in Brazil, the balance between innovation and budget impact in England, the effect of unethical medical practices on public perception in South Korea and the legitimacy of priority-setting processes in the USA. Providing policymakers are receptive to these issues, public participation activities may be re-conceptualized as processes that illuminate policy problems relevant to a particular context, thereby promoting an agenda-setting role for the public.

Originality/value
– The paper offers an empirical analysis of public involvement in the case of sofosbuvir, where the relevant considerations that bear on priority-setting decisions have been particularly stark. The perspectives that emerge suggest that public participation contributes to raising attention to issues that need to be addressed by policymakers. Public participation activities can thus contribute to setting policy agendas, even if that is not their explicit purpose. However, the actualization of this contribution is contingent on the receptiveness of policymakers.
Between consensus and contestation
Authors: Weale Albert 
Published: July 2016

Purpose– Noting that discussions of public participation and priority setting typically presuppose certain political theories of democracy, the purpose of this paper is to discuss two theories: the consensual and the agonistic. The distinction is illuminating when considering the difference between institutionalized public participation and contestatory participation.Design/methodology/approach– The approach is a theoretical reconstruction of two ways of thinking about public participation in relation to priority setting in health care, drawing on the work of Habermas, a deliberative theorist, and Mouffe, a theorist of agonism.Findings– The different theoretical approaches can be associated with different ways of understanding priority setting. In particular, agonistic democratic theory would understand priority setting as system of inclusions and exclusions rather than the determination of a consensus of social values, which is the typical deliberative way of thinking about the issues.Originality/value– The paper shows the value of drawing out explicitly the tacit assumptions of practices of political participation in order to reveal their scope and limitations. It suggests that making such theoretical presuppositions explicit has value for health services management in recognizing these implicit choices.
Alliance portfolio capability
Authors: Lichtenthaler Ulrich 
Published: July 2016

Purpose– The purpose of this paper is to develop a conceptual framework and propositions on a capability-based view that examine the role of a firm’s primary type of alliances, i.e., exploration or exploitation, in the determinants and impact of alliance portfolio capability.Design/methodology/approach– This is a conceptual research paper, which builds on prior conceptual and empirical management research.Findings– Regarding determinants, capability-based arguments indicate that firms with an emphasis on exploration alliances have higher levels of alliance portfolio capability. However, a focus on exploration alliances aggravates the development of alliance portfolio capability through alliance experience and a dedicated alliance function. Regarding impact, alliance portfolio capability may positively affect a firm’s alliance, innovation, and financial performance. While alliance portfolio capability is assumed to have an equally positive effect on alliance performance for all types of alliance portfolios, a relative focus on exploration alliances is expected to limit the positive effects of alliance portfolio capability on innovation and subsequent financial performance.Originality/value– These new conceptual arguments help to reconcile inconsistent earlier findings, and they deepen the understanding of interfirm differences in alliance portfolio capability and performance.
Decision-making processes in football clubs associated with an external advisory programme
Authors: Egli Benjamin Thomas , Schlesinger Torsten , Splinter Mariëlle , Nagel Siegfried 
Published: July 2016

PurposeThe purpose of this paper is to foster a better understanding of how decision-making processes work in sport clubs and to develop appropriate advisory concepts or management tools in order to successfully realize structural changes in sport clubs. This paper examines the decision-making processes associated with an external advisory programme. Based on the assumption of bounded rationality, the garbage can model is used to grasp these decision-making processes theoretically and to access them empirically.Design/methodology/approachBased on a case study framework, an in-depth analysis of the decision-making and implementation processes involved in an advisory programme was performed in ten selected football clubs. Guided interviews were conducted on the basis of the four streams of the garbage can model. The interviews were analysed with qualitative content analysis.FindingsResults show that three types of club can be distinguished in terms of their implementation processes: low implementation of the external input; partial implementation of the external input; and rigorous implementation of the external input. In addition, the analysis shows that the participants in the advisory programme are the key actors in both the decision-making process and the implementation.Originality/valueThe paper provides insights into the practicability of advisory programmes for sport clubs and the transfer to the clubs’ practical decision-making routines. Additionally, it shows how sport clubs deal with (external) advisory impulses, and which different decision-making practices underlie these processes.
Football clubs’ profitability after the Financial Fair Play regulation: evidence from Italy
Authors: Nicoliello Mario , Zampatti Davide 
Published: July 2016

PurposeIn 2009, the Union of European Football Associations approved the Financial Fair Play (FFP) regulations. These regulations refer to the requirements of transparency and financial conditions for football clubs participating in European competitions. The purpose of this paper is to combine the managerial and the economic points-of-view in order to understand if Italian football clubs are ready to comply with the new FFP rules.Design/methodology/approachIn the analysis, the authors focus on the main Italian football league, Serie A. Using business model analysis, the authors determine what the main profit determinants of football associations are, through panel data for 15 clubs from 2011-2013. The authors then try to match the statistical and managerial approach.FindingsThe results show that the key contributing factors to profits are on the costs side. In particular, the most relevant expenses are player wages. The core revenue for clubs comes from the net profit from player trading, while other income, such as TV rights, commercial and match-day proceeds, have no statistical significance for profit formation.Research limitations/implicationsThe main limitation of the analysis is that the survey regarded only on Italian Championship. So it is deeply influenced by the competitive structure of the Italian league that is different from that of other European leagues. Therefore, the authors think that the future developments of this work could be the examination of another European Championship, for example, English Premier League, and the compared analysis of Italian league and other European one.Practical implicationsThere is a close-link between costs and profitability, and especially between expenditure on players and the ability to close the financial year with a profit. Clubs must address the issue of player wages in order to follow a path of economic recovery towards profitability.Originality/valueIn the work the authors put together managerial point of view and economical one, in order to understand how FFP can impact on profitability of football clubs. The authors use an empirical econometrics model to test the hypothesis about business model of Italian Clubs.
Draft Genome Sequence of the
Mycobacterium tuberculosis
Complex Pathogen
M. mungi
, Identified in a Banded Mongoose (
Mungos mungo
) in Northern Botswana
Authors: Alexander Kathleen A. , Larsen Michelle H. , Robbe-Austerman Suelee , Stuber Tod P. , Camp Patrick M. 
Published: July 2016

ABSTRACT

Mycobacterium mungi
, a
Mycobacterium tuberculosis
complex pathogen, has emerged in banded mongoose in northern Botswana and Northwest Zimbabwe. The pathogen is transmitted through infected secretions used in olfactory communication behavior (K. A. Alexander, C. E. Sanderson, M. H. Larsen, S. Robbe-Austerman, M. C. Williams, and M. V. Palmer, mBio 7(3):e00281-16, 2016,
http://dx.doi.org/10.1128/mBio.00281-16
). We announce here the draft genome sequence of this emerging pathogen
.
Draft Genome Sequence of the Emerging Bivalve Pathogen
Vibrio tubiashii
subsp.
europaeus
Authors: Spinard Edward J. , Dubert Javier , Nelson David R. , Gomez-Chiarri Marta , Barja Juan L. 
Published: July 2016

ABSTRACT

Vibrio tubiashii
subsp.
europaeus
is a bivalve pathogen isolated during episodes of mortality affecting larval cultures in different shellfish hatcheries. Here, we announce the draft genome sequence of the type strain PP-638 and describe potential virulence factors, which may provide insight into the mechanism of pathogenicity.