Single-cell transcriptomic characterization of 20 organs and tissues from individual mice creates a Tabula Muris
Authors: Schaum Nicholas , Karkanias Jim , Neff Norma F , May Andrew P. , Quake Stephen R. , Wyss-Coray Tony , Darmanis Spyros , Batson Joshua , Botvinnik Olga , Chen Michelle B. , Chen Steven , Green Foad , Jones Robert , Maynard Ashley , Penland Lolita , Sit Rene V. , Stanley Geoffrey M. , Webber James T. , Zanini Fabio , Baghel Ankit S. , Bakerman Isaac , Bansal Ishita , Berdnik Daniela , Bilen Biter , Brownfield Douglas , Cain Corey , Chen Michelle B. , Chen Steven , Cho Min , Cirolia Giana , Conley Stephanie D. , Darmanis Spyros , Demers Aaron , Demir Kubilay , Morree Antoine de , Divita Tessa , Bois Haley du , Dulgeroff Laughing Bear Torrez , Ebadi Hamid , Espinoza F. Hernan , Fish Matt , Gan Qiang , George Benson M. , Gillich Astrid , Green Foad , Genetiano Geraldine , Gu Xueying , Gulati Gunsagar S. , Hang Yan , Hosseinzadeh Shayan , Huang Albin , Iram Tal , Isobe Taichi , Ives Feather , Jones Robert , Kao Kevin S. , Karnam Guruswamy , Kershner Aaron M. , Kiss Bernhard , Kong William , Kumar Maya E. , Lam Jonathan , Lee Davis P. , Lee Song E. , Li Guang , Li Qingyun , Liu Ling , Lo Annie , Lu Wan-Jin , Manjunath Anoop , May Andrew P. , May Kaia L. , May Oliver L. , Maynard Ashley , McKay Marina , Metzger Ross J. , Mignardi Marco , Min Dullei , Nabhan Ahmad N. , Neff Norma F , Ng Katharine M. , Noh Joseph , Patkar Rasika , Peng Weng Chuan , Penland Lolita , Puccinelli Robert , Rulifson Eric J. , Schaum Nicholas , Sikandar Shaheen S. , Sinha Rahul , Sit Rene V , Szade Krzysztof , Tan Weilun , Tato Cristina , Tellez Krissie , Travaglini Kyle J. , Tropini Carolina , Waldburger Lucas , Weele Linda J. van , Wosczyna Michael N. , Xiang Jinyi , Xue Soso , Youngyunpipatkul Justin , Zanini Fabio , Zardeneta Macy E. , Zhang Fan , Zhou Lu , Bansal Ishita , Chen Steven , Cho Min , Cirolia Giana , Darmanis Spyros , Demers Aaron , Divita Tessa , Ebadi Hamid , Genetiano Geraldine , Green Foad , Hosseinzadeh Shayan , Ives Feather , Lo Annie , May Andrew P. , Maynard Ashley , McKay Marina , Neff Norma F. , Penland Lolita , Sit Rene V. , Tan Weilun , Waldburger Lucas , Youngyunpipatkul Justin , Batson Joshua , Botvinnik Olga , Castro Paola , Croote Derek , Darmanis Spyros , DeRisi Joseph L. , Karkanias Jim , Pisco Angela , Stanley Geoffrey M. , Webber James T. , Zanini Fabio , Baghel Ankit S. , Bakerman Isaac , Batson Joshua , Bilen Biter , Botvinnik Olga , Brownfield Douglas , Chen Michelle B. , Darmanis Spyros , Demir Kubilay , Morree Antoine de , Ebadi Hamid , Espinoza F. Hernan , Fish Matt , Gan Qiang , George Benson M. , Gillich Astrid , Gu Xueying , Gulati Gunsagar S. , Hang Yan , Huang Albin , Iram Tal , Isobe Taichi , Karnam Guruswamy , Kershner Aaron M. , Kiss Bernhard M. , Kong William , Kuo Christin S. , Lam Jonathan , Lehallier Benoit , Li Guang , Li Qingyun , Liu Ling , Lu Wan-Jin , Min Dullei , Nabhan Ahmad N. , Ng Katharine M. , Nguyen Patricia K. , Patkar Rasika , Peng Weng Chuan , Penland Lolita , Rulifson Eric J. , Schaum Nicholas , Sikandar Shaheen S. , Sinha Rahul , Szade Krzysztof , Tan Serena Y. , Tellez Krissie , Travaglini Kyle J. , Tropini Carolina , Weele Linda J. van , Wang Bruce M. , Wosczyna Michael N. , Xiang Jinyi , Yousef Hanadie , Zhou Lu , Batson Joshua , Botvinnik Olga , Chen Steven , Darmanis Spyros , Green Foad , May Andrew P. , Maynard Ashley , Pisco Angela , Quake Stephen R. , Schaum Nicholas , Stanley Geoffrey M. , Webber James T. , Wyss-Coray Tony , Zanini Fabio , Beachy Philip A. , Chan Charles K. F. , Morree Antoine de , George Benson M. , Gulati Gunsagar S. , Hang Yan , Huang Kerwyn Casey , Iram Tal , Isobe Taichi , Kershner Aaron M. , Kiss Bernhard M. , Kong William , Li Guang , Li Qingyun , Liu Ling , Lu Wan-Jin , Nabhan Ahmad N. , Ng Katharine M. , Nguyen Patricia K. , Schaum Nicholas , Sikandar Shaheen S. , Sinha Rahul , Szade Krzysztof , Travaglini Kyle J. , Tropini Carolina , Wang Bruce M. , Weinberg Kenneth , Wosczyna Michael N. , Wu Sean , Yousef Hanadie , Barres Ben A. , Beachy Philip A. , Chan Charles K. F. , Clarke Michael F. , Darmanis Spyros , Huang Kerwyn Casey , Karkanias Jim , Kim Seung K. , Krasnow Mark A. , Kuo Christin S. , May Andrew P. , Neff Norma , Nusse Roel , Nguyen Patricia K. , Rando Thomas A. , Sonnenburg Justin , Wang Bruce M. , Weinberg Kenneth , Weissman Irving L. , Wu Sean M. , Quake Stephen R. , Wyss-Coray Tony 
Published: December 2017

The Tabula Muris ConsortiumWe have created a compendium of single cell transcriptome data from the model organism Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data represent a new resource for cell biology, revealing gene expression in poorly characterized cell populations and allowing for direct and controlled comparison of gene expression in cell types shared between tissues, such as T-lymphocytes and endothelial cells from distinct anatomical locations. Two distinct technical approaches were used for most tissues: one approach, microfluidic droplet-based 3’-end counting, enabled the survey of thousands of cells at relatively low coverage, while the other, FACS-based full length transcript analysis, enabled characterization of cell types with high sensitivity and coverage. The cumulative data provide the foundation for an atlas of transcriptomic cell biology.