bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Emotional Domain
Authors: Hammel Alice M , Yee Roberta L 
Published: October 2024

Abstract
The Individuals with Disabilities Act (IDEA) has some very specific language used to categorize students who are challenged by their emotions. This definition can be found in the Label-Free text itself. The most important thing to remember about this domain is that, as with the behavioral domain, it is an invisible disability. One cannot readily see the challenge and can make some of the incorrect assumptions that are often made about the behavioral domain. Emotional challenges are very real and can have a debilitating effect on students. Unfortunately, this debilitating effect can be exacerbated by teachers who do not, or will not, understand the challenges faced by their students.
The Sensory Domain
Authors: Hammel Alice M , Yee Roberta L 
Published: October 2024

Abstract
The human sensory systems are more complicated than is sometimes assumed. When one thinks of sensory differences, one often focuses on vision and hearing. However, those are only two senses that some students struggle with on a daily basis. Taste, touch, and smell are also affected. Two whole body systems are also to be considered: proprioceptive and vestibular. Proprioception is the concept of “body in space” and knowing where your limbs, toes, and fingers are. The vestibular system aids with balance and resetting the body as it rotates and moves. Students can struggle with any one, or more, of these seven sensory systems.
The Physical Domain
Authors: Hammel Alice M , Yee Roberta L 
Published: October 2024

Abstract
One may often think of the physical domain as something that may apply to a student who uses a wheelchair or needs a walker to be mobile at school. The physical domain applies to more than just arms and legs that may be temporarily or permanently in need of accommodations or modifications. It can also apply to any student who has a medical or other physical condition. Some of these differences are apparent, while others can be considered invisible. In particular, students with autoimmune disorders, cancer, or leukemia, or who have had complications from other illnesses, can be in need of accommodations or modifications either temporarily or permanently. Many of these students will have 504 Plans rather than Individual Education Programs (IEPs).
Unit Plans
Authors: Hammel Alice M , Yee Roberta L 
Published: October 2024

Abstract
It can be helpful to see how a set of plans with adaptations, accommodations, and modifications can look over a period of time. This chapter includes several sets of ideas from new to experienced teachers. Each teacher uses size, color, pacing, and modality in their teaching, as well as modifications when needed. The plans range from early childhood through high school students.
Mediation analysis in longitudinal study with high-dimensional methylation mediators
Authors: Cui Yidan , Lin Qingmin , Yuan Xin , Jiang Fan , Ma Shiyang , Yu Zhangsheng 
Published: October 2024

Abstract
Mediation analysis has been widely utilized to identify potential pathways connecting exposures and outcomes. However, there remains a lack of analytical methods for high-dimensional mediation analysis in longitudinal data. To tackle this concern, we proposed an effective and novel approach with variable selection and the indirect effect (IE) assessment based on both linear mixed-effect model and generalized estimating equation. Initially, we employ sure independence screening to reduce the dimension of candidate mediators. Subsequently, we implement the Sobel test with the Bonferroni correction for IE hypothesis testing. Through extensive simulation studies, we demonstrate the performance of our proposed procedure with a higher F$_{1}$ score (0.8056 and 0.9983 at sample sizes of 150 and 500, respectively) compared with the linear method (0.7779 and 0.9642 at the same sample sizes), along with more accurate parameter estimation and a significantly lower false discovery rate. Moreover, we apply our methodology to explore the mediation mechanisms involving over 730 000 DNA methylation sites with potential effects between the paternal body mass index (BMI) and offspring growing BMI in the Shanghai sleeping birth cohort data, leading to the identification of two previously undiscovered mediating CpG sites.
TRAITER: transformer-guided diagnosis and prognosis of heart failure using cell nuclear morphology and DNA damage marker
Authors: Hayashi Hiromu , Ko Toshiyuki , Dai Zhehao , Fujita Kanna , Nomura Seitaro , Kiyoshima Hiroki , Ishihara Shinya , Hamano Momoko , Komuro Issei , Yamanishi Yoshihiro 
Published: October 2024

Abstract

Motivation
Heart failure (HF), a major cause of morbidity and mortality, necessitates precise diagnostic and prognostic methods.

Results
This study presents a novel deep learning approach, Transformer-based Analysis of Images of Tissue for Effective Remedy (TRAITER), for HF diagnosis and prognosis. Using image segmentation techniques and a Vision Transformer, TRAITER predicts HF likelihood from cardiac tissue cell nuclear morphology images and the potential for left ventricular reverse remodeling (LVRR) from dual-stained images with cell nuclei and DNA damage markers. In HF prediction using 31 158 images from 9 patients, TRAITER achieved 83.1% accuracy. For LVRR prediction with 231 840 images from 46 patients, TRAITER attained 84.2% accuracy for individual images and 92.9% for individual patients. TRAITER outperformed other neural network models in terms of receiver operating characteristics, and precision–recall curves. Our method promises to advance personalized HF medicine decision-making.

Availability and implementation
The source code and data are available at the following link: https://github.com/HamanoLaboratory/predict-of-HF-and-LVRR.
The cingulum: a central hotspot for the battle against chronic intractable pain?
Authors: Kollenburg Linda , Arnts Hisse , Green Alexander , Strauss Ido , Vissers Kris , Vinke Saman , Kurt Erkan 
Published: October 2024

Abstract
Chronic pain causes a major burden on patient’s lives, in part due to its profound socioeconomic impact. Despite the development of various pharmacological approaches and (minor) invasive treatments, a subset of patients remain refractory, hence why alternative targeted neurosurgical interventions like cingulotomy and deep brain stimulation of the anterior cingulate cortex should be considered in the last resort. Despite clinical evidence supporting the potential of these treatments in the management of chronic intractable pain, physicians remain reluctant on its clinical implementation. This can be partially attributed to the lack of clear overviews summarizing existent data. Hence, this article aims to evaluate the current status of cingulotomy and deep brain stimulation of the anterior cingulate cortex in the treatment of chronic intractable pain, to provide insight in whether these neurosurgical approaches and its target should be reconsidered in the current era. In the current study, a literature searches was performed using the PubMed database. Additional articles were searched manually through reviews or references cited within the articles. After exclusion, 24 and 5 articles remained included in the analysis of cingulotomy and deep brain stimulation of the anterior cingulate cortex, respectively. Results indicate that various surgical techniques have been described for cingulotomy and deep brain stimulation of the anterior cingulate cortex. Cingulotomy is shown to be effective 51–53% and 43–64% of patients with neoplastic and non-neoplastic pain at ≤6 months follow-up, and 82% (9/11) and 76% (90/118) at ≥ 12months follow-up, respectively. With regard to deep brain stimulation of the anterior cingulate cortex, no data on neoplastic pain was reported, however, 59% (10/17) and 57% (8/14) of patients with non-neoplastic pain were considered responders at ≤ 6 months and ≥ 12months follow-up, respectively. The most reported adverse events include change in affect (&gt;6.9%, &gt;29/420) and confusion (&gt;4.8%, &gt;20/420) for cingulotomy, and infection (12.8%, 6/47), seizures (8.5%, 4/47) and decline in semantic fluency (6.4%, 3/47) for deep brain stimulation of the anterior cingulate cortex. It can be concluded that cingulotomy and deep brain stimulation of the anterior cingulate cortex are effective last resort strategies for patients with refractory non-neoplastic and neoplastic pain, especially in case of an affective emotional component. Future research should be performed on the cingulum as a neurosurgical target as it allows for further exploration of promising treatment options for chronic intractable pain.
RettDb: the Rett syndrome omics database to navigate the Rett syndrome genomic landscape
Authors: Cillari Nico , Neri Giuseppe , Pisanti Nadia , Milazzo Paolo , Borello Ugo 
Published: October 2024

Abstract
Rett syndrome (RTT) is a neurodevelopmental disorder occurring almost exclusively in females and leading to a variety of impairments and disabilities from mild to severe. In &gt;95% cases, RTT is due to mutations in the X-linked gene MECP2, but the molecular mechanisms determining RTT are unknown at present, and the complexity of the system is challenging. To facilitate and provide guidance to the unraveling of those mechanisms, we developed a database resource for the visualization and analysis of the genomic landscape in the context of wild-type or mutated Mecp2 gene in the mouse model. Our resource allows for the exploration of differential dynamics of gene expression and the prediction of new potential MECP2 target genes to decipher the RTT disorder molecular mechanisms.
Database URL: https://biomedinfo.di.unipi.it/rett-database/
Role of PCSK9 inhibitors in venous thromboembolism: current evidence and unmet clinical needs
Authors: Zuin Marco , Corsini Alberto , Dalla Valle Chiara , De Rosa Catia , Maloberti Alessandro , Mojoli Marco , Rizzo Massimiliano , Ciccirillo Francesco , Madrid Alfredo , Riccio Carmine , Grimaldi Massimo , Colivicchi Furio , Oliva Fabrizio , Temporelli Pier Luigi ,   Associazione Nazionale Medici Cardiologi Ospedalieri (ANMCO) Working Group on Cardiological Chronicity
Published: October 2024

Abstract
Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have recently emerged as promising therapeutic agents for lowering low-density lipoprotein cholesterol and reducing the risk of cardiovascular events. Moreover, preliminary evidence from randomized controlled trials (RCTs) suggests that PCSK9i may also offer beneficial effects for patients following venous thromboembolism (VTE), with the most significant reductions in risk appearing over time, particularly beyond the first year of treatment. However, there is a lack of randomized controlled data supporting their efficacy and safety in conjunction with standard anticoagulation therapy. This article aims to critically evaluate the existing evidence for the use of PCSK9i as a complementary therapy for VTE risk reduction, while also identifying unmet clinical and research needs and proposing potential strategies to address these knowledge gaps.
Prediction and classification of solar photovoltaic power generation using extreme gradient boosting regression model
Authors: Rinesh S , Deepa S , Nandan R T , Sachin R S , Thamil S V , Akash R , Arun M , Prajitha C , Kumar A P Senthil 
Published: October 2024

Abstract
Solar energy is well-positioned for adoption due to the aggregate demand for renewable energy sources and the reduced price of solar panels. Solar photovoltaic (PV) electricity has many benefits over wind power, including lower noise levels, quicker installation, and more location versatility. However, there are difficulties, including the possibility of unpredictability between accessible power supply and load demand that comes with the rapid use of intermittent renewable energy sources. Hence, this study proposes the Extreme Gradient Boosting regression-based Solar Photovoltaic Power Generation Prediction (XGB-SPPGP) model to predict and classify the usage of solar power successfully with minimal error. Extreme gradient boosting regression is an effective and reliable method for solar PV power generation predictions, particularly in cases where the target-input feature relationship is complex and non-linear. Relative humidity, temperature, clear-sky index, and time of day are the most critical input features to improve the model’s accuracy. A comprehensive and reliable evaluation is provided by validating the proposed model using data from various climatic locations. The model’s performance is then further investigated by conducting a seasonal study. Solar energy has the potential to be a reliable and long-term part of the electrical power system’s growth, and these findings have significant consequences for grid management, energy planning, and governance. With generation estimation capability, an IoT-based datalogger for a stand-alone PV panel is established. The outcomes and features acquired validate the suggested methods’ superiority in forecasting electricity production. The experimental outcomes of the XGB-SPPGP model increase the power generation forecasting ratio of 99.3%, accuracy ratio of 98.7%, overall performance ratio of 97.2%, and weather prediction ratio of 95.5% and reduce mean absolute error by 8.4% compared to other popular models.
Evaluating Riyadh's smart city initiatives: insights from the IMD Smart City Index framework
Authors: Hegazy Ibrahim Rizk , Mahboob Abdullah 
Published: October 2024

Abstract
This research article evaluates Riyadh's smart city initiatives using the IMD Smart City Index framework, identifying key strengths, weaknesses, and areas for improvement. The findings indicate that Riyadh excels in public safety, medical services, and digital connectivity, reflecting significant investments in these areas. However, the city faces challenges related to traffic congestion, air quality, and inclusiveness, highlighting the need for improved transportation solutions, stricter environmental regulations, and enhanced integration programs. To address these challenges, the study provides policy recommendations, including expanding digital infrastructure, improving public transportation, enhancing safety measures, promoting inclusivity, and increasing green spaces. Comparative analysis with leading smart cities, such as Singapore and Amsterdam, offers best practices that Riyadh can adopt. The study emphasizes the need for continuous monitoring and evaluation to ensure the effective implementation of smart city strategies, guiding policymakers and urban planners toward sustainable and inclusive urban development.
Constructing Lyapunov–Krasovskii functionals for linear positive continuous time difference systems
Authors: Aleksandrov Alexander 
Published: October 2024

Abstract
In this paper, a linear positive functional difference system with discrete and distributed delays is studied. It is proved that if the considered system is exponentially stable, then it admits both linear and diagonal quadratic Lyapunov–Krasovskii functionals. In addition, new exponential stability conditions for switched linear positive functional difference systems are obtained on the basis of a constructive approach to the design of common Lyapunov–Krasovskii functionals for the associated families of subsystems.
An L-Moment Approach for Portfolio Choice under Non-Expected Utility
Authors: Fallahgoul Hasan , Mancini Loriano , Stoyanov Stoyan 
Published: October 2024

Abstract
We develop and apply a novel semi-parametric estimation method based on L-moments. Unlike conventional moments, L-moments are linear in the data and therefore robust to outliers. The estimation method provides a series expansion that quickly converges to the underlying return distribution and can be used when conventional moments do not exist. An extensive empirical analysis of portfolio choice under non-expected utility demonstrates the effectiveness of our approach. Empirical results show that our method copes well with estimation risk, yields stable portfolio returns, and reaps the information content of moment returns beyond order four.
A Security Conundrum: Kin-State Engagement, Identity Recognition, and the 2012 Dispute between Romania and Serbia
Authors: Udrea Andreea 
Published: October 2024

Abstract
This article examines the relationship between national identity and foreign policy in the context of kin-state engagement in Europe. While the engagement of many European states with their ethnic kin abroad has been long defended as a form of minority protection in so far as it protects and promotes their particular identity and culture, de facto considerations of state security that define its scope have received little attention in the international relations (IR) scholarship. I show here that already in 2012 the dispute between Romania and Serbia over the identity and accommodation of the Vlach minority in Serbia is a conspicuous case in which considerations of (kin-)state security rather than minority protection have overtly justified the engagement of the kin-state. In fact, I argue that this case study calls attention to the multiplying significance of national identity for a kin-state: as a source of obligations, as well as one of (kin-)state ontological security. Yet, in this article, the contextual exploration highlights a tension between the two that originates in a lack of congruity between kin-state identity politics and home-state multiculturalism. While it appears to be unappeasable, in agreement with some constructivist IR scholarship, I contend that it could be reconciled. To this end, this article examines the scope of kin-state engagement at the intersection between justice and security and endorses the necessity to reconceptualize a state’s ontological security as a capability to adapt to a changing normative environment in Europe.
Secure in Diversity? Transborder Ethnicity, Transnational Minority Activism, and Ontological (In)Security in the European Union
Authors: Smith David J 
Published: October 2024

Abstract
The liberal vision of the early 1990s envisaged the eastward extension of the Western European security community formed during the Cold War, based on intergovernmental cooperation and integration around the shared norms embodied by the European Union (EU), Council of Europe, and Organisation for Security and Cooperation in Europe (OSCE). Yet, transborder ethnic ties have remained a security concern within the “New Europe.” As well as the external challenges posed by Russia’s aggression against Ukraine, growing transborder nationalism exhibited by Hungary and other states has also become a focus of tensions within the EU. These intra-EU concerns, I argue, should be understood primarily as an issue of ontological security and as part of a multilevel security dilemma implicating states, EU institutions, and national minorities as security-seeking non-state actors. The article focuses on the Federal Union of European Nationalities—a transnational umbrella NGO that in 2013–2021 led an unsuccessful European Citizens’ Initiative named “Minority SafePack” (MSPI) calling upon the European Commission to legislate on firmer guarantees of minority rights within EU member states. Applying the ontological security lens to the study of MSPI, I illustrate how it reflects specific claims voiced by transborder kin-minority activists consistently over the past century, before analyzing the counter-securitizing arguments deployed against it by states. Although MSPI was approved with a large majority within the European Parliament, the Commission ultimately rejected it. I consider why this was the case, as well as the implications of the rejection for the in varietate concordia concept that supposedly undergirds the European project.
Normative and Security Challenges of Transborder Ethnic Kinship in Africa: The Case of Ethiopia
Authors: Dessalegn Beza 
Published: October 2024

Abstract
This article extends the study of securitization of cross-border ethnicity beyond its conventional European focus, by analyzing ongoing security challenges surrounding ethnic Somalis in Ethiopia and their relationship to neighboring Somalia. In methodological terms, it looks beyond the irredentist prism through which this case is usually considered, applying newer conceptual and normative frameworks on cross-border ethnicity developed in a European context and assessing their applicability to Africa. Applying Brubaker's “triadic nexus' concept to the Ethiopian case, I discuss how the conclusion of the Ethiopia-Somalia war and Somalia's collapse as an external kin state did not end the securitization of cross-border Somali kinship, but merely repackaged it in new forms. In this regard, the article highlights a continued need to ensure the human security of Somalis in Ethiopia by recognizing and accommodating them as a cross-border ethnic group. From the standpoint of contemporary norms on the regulation of minority issues in interstate relations, the federalization model adopted by Ethiopia after 1991 seems to provide a promising foundation. Thus far, however, the hegemonic nature of the federal project has failed to grant Somalis an appropriate measure of internal self-determination.
Integrating Universal Hepatitis C Screening Into Adolescent Well Visits Is a “Win-Win” Scenario: Rationale and Demonstration of Real-world Feasibility and Implementation
Authors: Mangarelli Caren , Raghupatruni Preethi , Latimer Tomitra , Jhaveri Ravi 
Published: October 2024

Abstract
Hepatitis C virus (HCV) testing is recommended for all adults 18 years and older to increase identification of those with infection and facilitate prompt referral for curative antiviral therapy. While critical to promote elimination, this strategy excludes a key demographic group who are clearly at risk of undetected HCV infection and who could benefit from early treatment: adolescents. In this paper, we review the available data on the burden of HCV and the close association with injection drug use, discuss the rationale of universal testing in adolescents and, finally, present data from a quality improvement project implementing HCV testing into routine adolescent health visits.
miRNASNP-v4: a comprehensive database for miRNA-related SNPs across 17 species
Authors: Cao Wen , He Jiaxin , Feng Jing , Wu Xiaohong , Wu Tian , Wang Dongyang , Min Congcong , Niu Xiaohui , Gao Zexia , Guo An-Yuan , Gong Jing 
Published: October 2024

Abstract
Single nucleotide polymorphisms (SNPs) within microRNAs (miRNAs) and their target binding sites can influence miRNA biogenesis and target regulation, thereby participating in a variety of diseases and biological processes. Current miRNA-related SNP databases are often species-limited or based on outdated data. Therefore, we updated our miRNASNP database to version 4 by updating data, expanding the species from Homo sapiens to 17 species, and introducing several new features. In miRNASNP-v4, 82 580 SNPs in miRNAs and 24 836 179 SNPs in 3′UTRs of genes across 17 species were identified and their potential effects on miRNA secondary structure and target binding were characterized. In addition, compared to the last release, miRNASNP-v4 includes the following improvements: (i) gene enrichment analysis for gained or lost miRNA target genes; (ii) identification of miRNA-related SNPs associated with drug response and immune infiltration in human cancers; (iii) inclusion of experimentally supported immune-related miRNAs and (iv) online prediction tools for 17 animal species. With the extensive data and user-friendly web interface, miRNASNP-v4 will serve as an invaluable resource for functional studies of SNPs and miRNAs in multiple species. The database is freely accessible at http://gong_lab.hzau.edu.cn/miRNASNP/.