bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mercier de Compiègne et la question de la mode
Authors: Kahia Béchir 
Published: December 2015

Au XVIIIe siècle, la mode parisienne connaît de profondes mutations. L’offre vestimentaire variée est illustrée par une presse de mode devenue périodique qui renouvelle ses propositions grâce à de séduisantes gravures. Surtout une figure iconique émerge de ce siècle des Lumières : la marchande de mode et sa représentante la plus célèbre, mademoiselle Rose Bertin, « ministre des modes » de la reine de France, Marie-Antoinette. Les femmes étaient comme des oiseaux amusants qui changent de plumage deux ou trois fois par jour. Cet engouement pour la mode a provoqué de vives réactions notamment chez Mercier de Compiègne. Dans Comment m’habillerai-je ? Mercier établit un lien indéniable entre la mode vestimentaire et la puissance de la nation. Le respect de la simplicité traduit réserve et modestie ; deux vertus caractéristiques de la nature humaine. Tout vêtement pouvant exalter les prétentions des femmes est en opposition avec leur destination naturelle. Les réflexions de Mercier sont emblématiques de ce retour à la nature. L’auteur de Comment m’habillerai-je ? exalte ainsi l’image de la beauté saine et naturelle. Ces réflexions veulent gagner également la Cour et changer les règles du bon goût.
Cicero, De oratore 2.90-92: A Probable Case of ‘Author Variant’
Authors: Renting D.S.A. 
Published: December 2015

AtDe oratore2.90-92, themutili(M) omit a passage in which the orator L. Fufius is severely criticized. It is solely transmitted by theintegri(L). In the present paper I argue that the ‘lacuna’ in M is not accidental: it is more probable that Cicero himself, not long after he had completed and publishedDe oratore, revised 2.90-92 and deleted the Fufius-passage. The outburst against Fufius is to be seen as a covert attack on one of Cicero’s personal enemies, the Caesarian Q. Fufius Calenus, and Cicero’s revision of 2.90-92 can well be understood as being due to changed circumstances, notably his improved relationship with Caesar.While M contains the revised version of 2.90-92, L does not contain the original one. This can be gathered from certain problems which mar the L-text. These problems are, in my view, to be connected with Cicero’s later revision of the passage: it seems likely that L’s text is due to contamination of the two versions. The original version can no longer be retrieved with certainty in all detail. Under the circumstances, the best we can do is to edit 2.90-92 according to the revised version (= M).
Habenaria luquanensis (Orchidaceae), a new species from Yunnan, China
Authors: LONG BO , HU GUANGWAN , KAMANDE ELIZABETH MWIHAKI , MUTELE NGUMBAU VERONICAH , WEI NENG 
Published: December 2015

Habenaria luquanensis from Yunnan Province is described and illustrated. This new species most closely resembles H. delavayi in having a basal leaf rosette, flowers with a concave and abaxially keeled dorsal sepal and linear petals. It is distinguished by herbaceous, loosely arranged rosette leaves (versus tightly adpressed to each other), a lip which is 3-lobed only to 1/3–1/4 from the base and has narrowly oblong lateral lobes (versus deeply 3-lobed nearly to the base with linear-cuneate lateral lobes). Another similar species is H. finetiana, but this species can be distinguished by its cauline leaves, longer floral bracts, petals forming a hood with the dorsal sepal, a lip which is 3-lobed only in the upper half and rhombic, serrate lateral lobes, a spur which is nearly as long as the ovary, and central rostellum lobe not clearly visible.
Further Exploring and Quantifying Uncertainties for Extended Reconstructed Sea Surface Temperature (ERSST) Version 4 (v4)
Authors: Huang Boyin , Thorne Peter W. , Smith Thomas M. , Liu Wei , Lawrimore Jay , Banzon Viva F. , Zhang Huai-Min , Peterson Thomas C. , Menne Matthew 
Published: December 2015

Abstract
The uncertainty in Extended Reconstructed SST (ERSST) version 4 (v4) is reassessed based upon 1) reconstruction uncertainties and 2) an extended exploration of parametric uncertainties. The reconstruction uncertainty (Ur) results from using a truncated (130) set of empirical orthogonal teleconnection functions (EOTs), which yields an inevitable loss of information content, primarily at a local level. The Ur is assessed based upon 32 ensemble ERSST.v4 analyses with the spatially complete monthly Optimum Interpolation SST product. The parametric uncertainty (Up) results from using different parameter values in quality control, bias adjustments, and EOT definition etc. The Up is assessed using a 1000-member ensemble ERSST.v4 analysis with different combinations of plausible settings of 24 identified internal parameter values. At the scale of an individual grid box, the SST uncertainty varies between 0.3° and 0.7°C and arises from both Ur and Up. On the global scale, the SST uncertainty is substantially smaller (0.03°–0.14°C) and predominantly arises from Up. The SST uncertainties are greatest in periods and locales of data sparseness in the nineteenth century and relatively small after the 1950s. The global uncertainty estimates in ERSST.v4 are broadly consistent with independent estimates arising from the Hadley Centre SST dataset version 3 (HadSST3) and Centennial Observation-Based Estimates of SST version 2 (COBE-SST2). The uncertainty in the internal parameter values in quality control and bias adjustments can impact the SST trends in both the long-term (1901–2014) and “hiatus” (2000–14) periods.
Comprehensive Emergency Airway Response Team (EART) Training and Education
Authors: Tsai Angela C. , Krisciunas Gintas P. , Brook Chris , Basa Krystyne , Gonzalez Mauricio , Crimlisk Janet , Silva Julie , Grillone Gregory A. 
Published: December 2015

Objective: To evaluate the efficacy and utility of simulation of the Emergency Airway Response Team (EART) at a tertiary care hospital to improve team dynamics and confidence and knowledge in managing an emergency airway. Methods: This was a descriptive, quantitative performance improvement study. From September 1, 2013, to December 1, 2013, 177 members of the EART from anesthesia, otolaryngology, trauma surgery, emergency medicine, ICU nursing, and respiratory therapy participated in emergency airway simulations. Team dynamics and confidence levels and knowledge of EART were assessed using pre-and post-simulation questionnaires. Results: All participants regardless of their role, experience in the medical field, or any prior exposure to a difficult airway showed significant improvement in self-rated team participation and confidence and objective knowledge regarding EART after undergoing simulation. Conclusion: Our study highlights the efficacy and utility of simulation in assessing personnel team dynamics and confidence levels and knowledge of emergency airway scenarios. Practitioners in all fields and level of experience benefit in EART training and simulation. We hope that with this information, we will be able to conduct future studies on reduction of patient morbidity and mortality.
Perfusion and diffusion characteristics of endometrial malignancy based on intravoxel incoherent motion MRI at 3.0 T: comparison with normal endometrium
Authors: Liu Jingyan , Wan Yeda , Wang Zhi , Qi Yang , Qu Pengpeng , Liu Yixin 
Published: December 2015

Background There has been a growing need for a non-invasive imaging method for the accurate diagnosis and differentiation of endometrial malignancy (EM). Purpose To study tissue characteristics of EM using an intravoxel incoherent motion (IVIM) model and to assess their diagnostic potential. Material and Methods Sixty-eight EMs and 31 healthy participants were prospectively recruited for diffusion-weighted (13 b-values, b = 0–3,000 s/mm2) and standard magnetic resonance imaging (MRI). A bi-exponential analysis was performed to derive f (perfusion fraction), D* (pseudodiffusion coefficient), and D (true diffusion coefficient) in EM and normal endometrium (NE). Apparent diffusion coefficient (ADC) was calculated. Student’s t test, the Mann–Whitney U test and a receiver operating characteristics (ROC) curve analysis were performed. Results EM had lower f (37.809 ± 12.158%) and was significantly different from NE ( P < 0.001). However, the EMs had higher D (0.503 ± 0.155 × 10−3 mm2/s) and D* (19.796 ± 20.029 × 10−3 mm2/s) and were all significantly different from NE ( P < 0.001). D was significantly lower than ADC in NE ( P < 0.001) but not in EM ( P > 0.05). f ≤ 48.5%, D > 0.432 × 10−3 mm2/s, D* > 4.94 × 10−3 mm2/s, and ADC ≤ 0.542 × 10−3 mm2/s could diagnose EM (AUC 0.786–0.961). Conclusion EM has distinctive IVIM perfusion and diffusion characteristics with promising potential for earlier non-invasive diagnosis.
Mean Platelet Volume as a Surrogate Marker for Platelet Activation in Patients With Idiopathic Pulmonary Fibrosis
Authors: Ntolios P. , Papanas N. , Nena E. , Boglou P. , Koulelidis A. , Tzouvelekis A. , Xanthoudaki M. , Tsigalou C. , Froudarakis M. E. , Bouros D. , Mikhailidis D. P. , Steiropoulos P. 
Published: December 2015

Background: Idiopathic pulmonary fibrosis (IPF) is associated with a prothrombotic state. Aim: To study mean platelet volume (MPV) and Platelet Distribution Width (PDW) as markers of platelet activation and their potential association with lung function in patients with recently diagnosed IPF. Materials and Methods: This study included 56 patients with IPF (age 64.9±7.4 years) and 79 controls (age 64.2 ± 5.9 years). Results: An inverse relation was demonstrated between platelet count and MPV in the control group but not among patients with IPF. Platelet count was significantly lower in patients with IPF compared with controls (230 ± 60 vs 256 ± 75 × 103/μL, P = .038). Conversely, MPV was higher in patients versus controls (10.3 ± 1.2 vs 9.8 ± 1.2 fl, P = .024), while there was no difference between the groups in PDW. Respiratory function was, as expected, significantly impaired in patients with IPF versus controls in terms of forced expiratory volume in first second (FEV1; 67.2 ± 23.1 vs 102.6 ± 15.9% of predicted value, P < .001), forced vital capacity (FVC; 65.3 ± 21 vs 95.2 ± 16.1% of predicted value, P < .001), FEV1/FVC (83.1 ± 15 vs 87.5 ± 6.4%, P = .041) and partial pressure of oxygen in arterial blood (PaO2; 67.1 ± 10.3 vs 81.5 ± 15.2 mm Hg, P < .001). No significant correlation was seen between MPV and FVC ( r = −.1497, P = .275), MPV and lung diffusion capacity for carbon monoxide ( r = .035, P = .798) and total lung capacity ( r = .032, P = .820). Conclusions: Patients with IPF exhibit higher MPV values and lower platelet count. Further studies are needed to assess the clinical implications of these findings.
Meningoencephalitis in cats in Austria: a study of infectious causes, including Encephalitozoon cuniculi
Authors: Künzel Frank , Rebel-Bauder Barbara , Kassl Christine , Leschnik Michael , Url Angelika 
Published: December 2015

Objectives Despite comprehensive diagnostics, the aetiology of meningoencephalitis (ME) in cats often remains undetermined. As a result of recently published surveys, Encephalitozoon cuniculi has gained growing importance in cats not only with ocular disorders, but also with central nervous system disease. Therefore, it was hypothesised that E cuniculi may be an underestimated pathogen in the development of feline non-suppurative and/or granulomatous ME. Methods As a first step, histopathological sections of the brain of cats with encephalopathy were retrospectively reviewed to identify cases of granulomatous ME. In a second step, an immunohistochemical screening for detection of E cuniculi was performed in cases with ME of unknown origin. Results In 59/89 (66.3%) cats with ME, an aetiologically relevant pathogen was detected. Forty-three of 89 (48.3%) cats had a diagnosis of feline infectious peritonitis. In 14/89 (15.7%) cats, protozoan cysts were identified and infection with Toxoplasma gondii was confirmed by immunohistochemistry (IHC) in all cases. In 2/89 (2.3%) cats with granulomatous ME, fungal organisms were identified. Thirty of 89 (33.7%) cats with ME of unknown origin that underwent IHC for the detection of E cuniculi remained negative. Conclusions and relevance The results of this study suggest that E cuniculi is unlikely to be directly associated with (non-suppurative and/or granulomatous) ME in cats in Austria.
Adrenal Cushing’s syndrome in pregnancy: Clinical and molecular characterisation of a case
Authors: Trinh Anne , Chan Irene , Alexiadis Maria , Pell Medina , Kumar Beena , Fuller Peter J 
Published: December 2015

Background Cushing’s syndrome is rare during pregnancy and more commonly due to adrenal pathology, in contrast to the non-pregnant population. Increased levels of cortisol-binding globulin and placental production of corticotropin-releasing hormone and adrenocorticotropic hormone complicate the diagnostic strategies usually employed. Case A 32-year-old G1P0 at 15/40 gestation presented with severe peripheral oedema and excessive weight gain. Examination revealed pitting oedema to the abdominal wall, wide violaceous striae, moon facies and acne. Cortisol excess was confirmed with elevated 24 h urinary free cortisol, raised midnight salivary cortisol and lack of diurnal variation. Adrenocorticotropic hormone ranged between 22 and 36 pg/ml (5–8 pmol/L). Fetal ultrasound confirmed a single live intrauterine gestation with an incidental finding of a maternal left adrenal mass. Magnetic resonance imaging confirmed an adrenal mass measuring 3.0 × 4.4 × 4.1 cm. She underwent a laparoscopic left adrenalectomy at 18 weeks’ gestation without complication. Her postoperative cortisol level was undetectable. Hydrocortisone replacement was commenced with slow weaning as an outpatient. Histology was consistent with an adrenal adenoma. Immunohistochemistry revealed strong staining for the luteinising hormone/choriogonadotropin receptor, and expression of the luteinising hormone/choriogonadotropin receptor gene was in the range seen in normal ovary. DNA analysis revealed a mutation in GNAS encoding the Gα subunit in the cyclic adenosine monophosphate pathway. Conclusion Cushing’s syndrome may present in pregnancy as a result of βhCG acting on the luteinising hormone/choriogonadotropin receptor over-expression by the adenoma amplifying the aberrant cyclic adenosine monophosphate signaling implicated in the development of cortisol-secreting adenomas.
An international registry for primary ciliary dyskinesia
Authors: Werner Claudius , Lablans Martin , Ataian Maximilian , Raidt Johanna , Wallmeier Julia , Große-Onnebrink Jörg , Kuehni Claudia E. , Haarman Eric G. , Leigh Margaret W. , Quittner Alexandra L. , Lucas Jane S. , Hogg Claire , Witt Michal , Priftis Kostas N. , Yiallouros Panayiotis , Nielsen Kim G. , Santamaria Francesca , Ückert Frank , Omran Heymut 
Published: December 2015

Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder leading to chronic upper and lower airway disease. Fundamental data on epidemiology, clinical presentation, course and treatment strategies are lacking in PCD. We have established an international PCD registry to realise an unmet need for an international platform to systematically collect data on incidence, clinical presentation, treatment and disease course.The registry was launched in January 2014. We used internet technology to ensure easy online access using a web browser underwww.pcdregistry.eu. Data from 201 patients have been collected so far. The database is comprised of a basic data form including demographic and diagnostic information, and visit forms designed to monitor the disease course.To establish a definite PCD diagnosis, we used strict diagnostic criteria, which required two to three diagnostic methods in addition to classical clinical symptoms. Preliminary analysis of lung function data demonstrated a mean annual decline of percentage predicted forced expiratory volume in 1 s of 0.59% (95% CI 0.98–0.22).Here, we present the development of an international PCD registry as a new promising tool to advance the understanding of this rare disorder, to recruit candidates for research studies and ultimately to improve PCD care.
Clinical decision support software for diabetic foot risk stratification: development and formative evaluation
Authors: Schoen Deborah E. , Glance David G. , Thompson Sandra C. 
Published: December 2015

AbstractBackgroundIdentifying people at risk of developing diabetic foot complications is a vital step in prevention programs in primary healthcare settings. Diabetic foot risk stratification systems predict foot ulceration. The aim of this study was to explore the views and experiences of potential end users during development and formative evaluations of an electronic diabetic foot risk stratification tool based on evidence‐based guidelines and determine the accuracy of the tool.MethodsFormative evaluation of the risk tool occurred in five stages over an eight‐month period and employed a mixed methods research design consisting of semi‐structured interviews, focus group and participant observation, online survey, expert review, comparison to the Australian Guidelines and clinical testing.ResultsA total of 43 healthcare practitioners trialled the computerised clinical decision support system during development, with multiple software changes made as a result of feedback. Individual and focus group participants exposed critical design flaws. Live testing revealed risk stratification errors and functional limitations providing the basis for practical improvements. In the final product, all risk calculations and recommendations made by the clinical decision support system reflect current Australian Guidelines.ConclusionsDevelopment of the computerised clinical decision support system using evidence‐based guidelines can be optimised by a multidisciplinary iterative process of feedback, testing and software adaptation by experts in modern development technologies.
Effects of different types of fluid resuscitation for hemorrhagic shock on splanchnic organ microcirculation and renal reactive oxygen species formation
Authors: Wu Chun-Yu , Chan Kuang-Cheng , Cheng Ya-Jung , Yeh Yu-Chang , Chien Chiang-Ting ,   on behalf of the NTUH Center of Microcirculation Medical Research (NCMMR)
Published: December 2015

Abstract
Introduction
Fluid resuscitation is an indispensable procedure in the acute management of hemorrhagic shock for restoring tissue perfusion, particularly microcirculation in splanchnic organs. Resuscitation fluids include crystalloids, hypertonic saline (HTS), and synthetic colloids, and their selection affects the recovery of microcirculatory blood flow and reactive oxygen species (ROS) formation, which is often evident in the kidney, following reperfusion. In this study, the effects of acute resuscitation with 0.9 % saline (NS), 3 % HTS, 4 % succinylated gelatin (GEL), and 6 % hydroxyethyl starch (HES) 130/0.4 were compared in a hemorrhagic shock rat model to analyze restoration of microcirculation among various splanchnic organs and the gracilis muscle and reperfusion-induced renal ROS formation.

Methods
A total of 96 male Wistar rats were subjected to sham operation (sham group), hemorrhagic shock (control group), and resuscitation with NS, HTS, GEL and HES. Two hours after resuscitation, changes in the mean arterial pressure (MAP), serum lactate level and the microcirculatory blood flow among various splanchnic organs, namely the liver, kidney, and intestine (mucosa, serosal muscular layer, and Peyer’s patch), and the gracilis muscle, were compared using laser speckle contrast imaging. Renal ROS formation after reperfusion was investigated using an enhanced in vivo chemiluminescence (CL) method.

Results
Microcirculatory blood flow was less severely affected by hemorrhaging in the liver and gracilis muscle. Impairment of microcirculation in the kidney was restored in all resuscitation groups. Resuscitation in the NS group failed to restore intestinal microcirculation. Resuscitation in the HTS, GEL, and HES groups restored intestinal microcirculatory blood flow. By comparison, fluid resuscitation restored hemorrhagic shock-induced hypotension and decreased lactatemia in all resuscitation groups. Reperfusion-induced in vivo renal ROS formation was significantly higher in the GEL and HES groups than in the other groups.

Conclusion
Although fluid resuscitation with NS restored the MAP and decreased lactatemia following hemorrhagic shock, intestinal microcirculation was restored only by other volume expanders, namely 3 % HTS, GEL, and HES. However, reperfusion-induced renal ROS formation was significantly higher when synthetic colloids were used.
Immunosuppressive CD11b+Ly6Chi monocytes in pristane-induced lupus mouse model
Authors: Ma Huijuan , Wan Suigui , Xia Chang-Qing 
Published: December 2015

Abstract
Myeloid-derived suppressor cells with immunosuppressive functions have been described to be associated with one of the mechanisms by which malignant tumors escape immune surveillance. However, little is known about the role of myeloid-derived suppressor cells in autoimmunity. In the current study, when we attempted to characterize the peritoneal cells in pristane-induced lupus model, as reported previously, we observed that there were markedly increased CD11b+Ly6Chi monocytes. Surprisingly, this type of monocytes was almost phenotypically identical to the reported monocytic myeloid-derived suppressor cells. Further analysis on how these CD11b+Ly6Chi cells affected T cell response showed that they strongly suppressed T cell proliferation in vitro in a manner dependent on cell–cell contact, NO, and PGE2. In addition, we found that CD11b+Ly6Chi monocytes inhibited Th1 differentiation but enhanced development of forkhead box p3+CD4+ regulatory T cells. Consistent with the in vitro experimental results, the in vivo adoptive cell transfer study showed that infusion of pristane-treated syngeneic CD11b+Ly6Chi monocytes significantly suppressed the production of anti-keyhole limpet hemocyanin antibodies induced by keyhole limpet hemocyanin immunization. In addition, we found that CD11b+Ly6Chi monocytes were also increased significantly in spleen and peripheral blood and showed immunosuppressive characteristics similar to their peritoneal counterparts. Our findings indicate that CD11b+Ly6Chi monocytes in a pristane-induced lupus mouse model are monocytic myeloid-derived suppressor cells instead of inflammatory monocytes, as demonstrated previously. To our knowledge, this is the first to describe myeloid-derived suppressor cells in a pristane-induced lupus mouse model, which may lead to a better understanding of the role of CD11b+Ly6Chi monocytes in this specific pristane-induced lupus model.