bluuebunny/crossref_metadata_2025_split huggingface dataset:
Augmented reality, virtual reality and 3D printing for the co-creation of value for the visitor experience at cultural heritage places
Authors: Jung Timothy Hyungsoo , tom Dieck M. Claudia 
Published: April 2017

Purpose
This paper aims to propose a value co-creation framework through examining the opportunities of implementing augmented reality, virtual reality and 3D printing into the visitor experience at cultural heritage places.

Design/methodology/approach
This study proposes the conceptual model of value co-creation using a case-study approach by presenting some cases of a cultural heritage place in the UK.

Findings
The findings of this study suggest that the effective use of multiple technologies in the context of cultural heritage places contributes to the co-creation of value for both cultural heritage organisations and also for visitors’ pre-visit, onsite and post-visit experience. Businesses can benefit from increased spending, intention to return and positive word-of-mouth, while visitors receive a personalised, educational, memorable and interactive experience.

Practical implications
Cultural heritage places have to find new ways to survive increasingly fierce competition. Using technology and the concept of value co-creation can prove to be a valuable concept in an attempt to attract new target markets, enhance visitors’ experience, create positive word-of-mouth and revisit intentions.

Originality/value
Recently, increased importance has been placed on the co-creation of value to account for consumers' interest in playing some part in the development of services and products. This study takes a holistic approach using augmented reality, virtual reality and 3D printing from a value co-creation perspective.
Ethylene detection using TiO2–WO3 composite sensor for fruit ripening applications
Authors: Kathirvelan Jayaraman , Vijayaraghavan Rajagopalan , Thomas Anna 
Published: April 2017

Purpose
The purpose of this paper was to develop a chemo-resistive sensor based on TiO2–WO3 composite material to detect and estimate ethylene released from the fruit ripening process to ensure food safety.

Design/methodology/approach
The ethylene sensor has been fabricated using TiO2–WO3 composite material through the sol-gel method.

Findings
The sensitivity of the sensor obtained using the pre-calibrated ethylene is found to be 46.2 per cent at 200 ppm ethylene concentration, and the proposed sensor could measure 8 ppm as the lowest concentration.

Originality/value
The sensor was tested for continuous ethylene detection during natural ripening of fruits and hence is useful for ensuring food safety through discrimination of the type of fruit ripening. A TiO2–WO3 composite ethylene sensor is developed for the first time.
The release of pro‐inflammatory cytokines is mediated via mitogen‐activated protein kinases rather than by the inflammasome signalling pathway in keratinocytes
Authors: Ondet Thomas , Muscatelli‐Groux Béatrice , Coulouarn Cédric , Robert Sacha , Gicquel Thomas , Bodin Aude , Lagente Vincent , Grimaud Jean‐Alexis 
Published: April 2017

SUMMARYToll‐like receptors (TLRs) are expressed in the skin and airway epithelial tissues, which are the most important sites of host–pathogen interactions. TLRs recognize the 3‐D structures of pathogen‐associated molecules and are therefore useful markers of the innate immune response. Here, we investigated the role of lipopolysaccharides and monosodium urate (MSU) crystals in the activation of the TLR and NOD‐like receptor (NLR) pathways in human keratinocytes. Analysis of the inflammasome compounds revealed that NOD‐like receptor P3 and TLR4, both of which are components of inflammasome complexes involved in the activation of interleukin (IL)‐1β, were not expressed in keratinocytes. Transcriptomic analysis showed that the combination of MSU and lipopolysaccharide priming did not elicit significant results compared to MSU treatment, which induced the expression of TLR2, IL‐6 and IL‐8/chemokine (C‐X‐C motif) ligand 8 CXCL8 in the keratinocyte cell line HaCaT. Furthermore, MSU promoted the phosphorylation of extracellular signal‐regulated kinase 1/2 and MAPK14/p38α mitogen‐activated protein kinases. We concluded that MSU stimulates a pro‐inflammatory response in keratinocytes via mitogen‐activated protein kinase pathway to induce production of IL‐8/CXCL8 chemokine (C‐X‐C motif) ligand 8 and TLR2.
Successful long‐term maintenance following Nutrition Care Process Terminology implementation across a state‐wide health‐care system
Authors: Vivanti Angela , O'Sullivan Therese A. , Porter Jane , Hogg Marion 
Published: April 2017

AimThree years following a state‐wide Nutrition Care Process Terminology (NCPT) implementation project, the present study aimed to (i) assess changes in NCPT knowledge and attitudes, (ii) identify implementation barriers and enablers and (iii) seek managers’ opinions post‐implementation.MethodsPre‐implementation and three years post‐implementation, all Queensland Government hospitals state‐wide were invited to repeat a validated NCPT survey. Additionally, a separate survey sought dietetic managers’ opinions regarding NCPT’s use and acceptance, usefulness for patient care, role in service planning and continued use.ResultsA total of 238 dietitians completed the survey in 2011 and 82 dietitians in 2014. Use of diagnostic statement in the previous six months improved (P < 0.001). Perceptions of NCPT’s importance (P < 0.020) and benefits of incorporating NCPT into practice (P = 0.029) increased. Time to complete NCPT documentation (P < 0.013) and access to mentors decreased (P < 0.001).Other areas including enhanced attitudes, familiarity, confidence, views, knowledge and incorporation into practice were sustained (P > 0.05). Key elements in sustaining NCPT implementation over three years included ongoing management support, workshops/tutorials, discussion and mentor and peer support. The most valued resources were pocket guides, ongoing workshops/tutorials and mentor support. Dietetic managers held many positive NCPT views, however, opinions differed around the usefulness of service planning, safer practice, improving patient care and facilitating communication. Some managers would not support NCPT unless it was recommended for practice.ConclusionsImmediate improvements following the NCPT implementation project were sustained over three years. Moving forward, a professional focus on continuing to incorporate NCPT into standard practice will provide structure for process and outcomes assessment.
The influence of substance use on depressive symptoms among young adult black men: The sensitizing effect of early adversity
Authors: Kogan Steven M. , Cho Junhan , Oshri Assaf , MacKillop James 
Published: April 2017

Background and ObjectivesDepressive symptoms have been identified as an important consequence of substance use. Both heavy drinking and marijuana use have acute and short‐term effects on systems that regulate emotion, increasing the potential for substance use to induce problems with negative affect and irritability. We investigated the effects of alcohol and marijuana use on depressive symptoms among a sample of young Black men. We also tested the stress sensitization hypothesis that exposure to adverse childhood experiences would amplify the influence of substance use on men's depressive symptoms.MethodsHypotheses were tested with 505 rural Black men who, at ages 19–22 years, provided data on their substance use, adverse childhood experiences, and depressive symptoms; they provided data again 18 months later.ResultsSubstance use forecasted increases in depressive symptoms; cross‐lagged analyses yielded no evidence for the inverse path, depressive symptoms increasing substance use. The impact of substance use on depressive symptoms was amplified among young Black men who were exposed to adverse childhood experiences. Substance use did not significantly predict depressive symptoms when adversity was low.Discussion and ConclusionsOur findings suggest that, during young adulthood, substance use increases depressive symptoms among Black men who were exposed to childhood adversity. Because childhood adversity disproportionately affects Black men, these findings inform future cross‐group research designed to investigate racial disparities in the consequences of substance use.Scientific SignificanceDepressive symptoms may be understood as an effect as well as a cause of substance use, particularly among vulnerable young Black men. (Am J Addict 2017;26:400–406).
Protease‐activated receptor‐2 suppresses interleukin (IL)‐10 expression in B cells via upregulating Bcl2L12 in patients with allergic rhinitis
Authors: Xue J.‐M. , Yang L.‐T. , Yang G. , Geng X.‐R. , Liu Z.‐Q. , Wang S. , Zhao H.‐L. , Liu Z.‐G. , Zhao C.‐Q. , Yang P.‐C. 
Published: April 2017

AbstractBackground and aimsThe function of interleukin (IL)‐10‐producing B cells (B10 cell) is compromised in patients with allergic diseases. Protease‐activated receptor (PAR)‐2 has immunoregulatory functions. This study aimed to elucidate the role of PAR2 in the suppression of IL‐10 expression in peripheral B cells.MethodsPeripheral blood B cells were collected from patients with allergic rhinitis (AR). A correlation between the expression of Bcl2‐like protein 12 (Bcl2L12) and IL‐10 in the B cells was analyzed. An AR mouse model was developed.ResultsWe observed that the expression of IL‐10 was lower in the peripheral B cells from patients with airway allergy. A negative correlation was identified between the expression of IL‐10 and PAR2 in B cells. Activation of PAR2 of B cells increased the expression of Bcl2L12 and suppression of LPS‐induced IL‐10 expression, which were inhibited by knocking down the Bcl2L12 gene. Treating B cells from AR patients with Bcl2L12‐shRNA‐carrying liposomes reversed the capability of IL‐10 expression and the immunosuppressive function. Administration of Bcl2L12 shRNA‐carrying liposomes attenuated experimental AR in mice.ConclusionsActivation of PAR2 inhibits the expression of IL‐10 in B cells, which can be reversed by treating B cells with Bcl2L12 shRNA‐carrying liposomes. The data suggest that regulation of Bcl2L12 may be a novel approach in the treatment for AR.
A Note on Marginalization of Regression Parameters from Mixed Models of Binary Outcomes
Authors: Hedeker Donald , du Toit Stephen H. C. , Demirtas Hakan , Gibbons Robert D. 
Published: April 2017

Summary
This article discusses marginalization of the regression parameters in mixed models for correlated binary outcomes. As is well known, the regression parameters in such models have the “subject-specific” (SS) or conditional interpretation, in contrast to the “population-averaged” (PA) or marginal estimates that represent the unconditional covariate effects. We describe an approach using numerical quadrature to obtain PA estimates from their SS counterparts in models with multiple random effects. Standard errors for the PA estimates are derived using the delta method. We illustrate our proposed method using data from a smoking cessation study in which a binary outcome (smoking, Y/N) was measured longitudinally. We compare our estimates to those obtained using GEE and marginalized multilevel models, and present results from a simulation study.
The influence of flow on learning outcomes: An empirical study on the use of clickers
Authors: Buil Isabel , Catalán Sara , Martínez Eva 
Published: April 2017

AbstractFlow is a state of total absorption and concentration in an activity that is desirable for students, as it enhances the learning experience. Due to the importance of flow for learning, this research investigates the influence of three flow preconditions—namely balance of skill and challenge, feedback and goal clarity—on students' flow, operationalized as heightened concentration, sense of control and autotelic experience, while using clickers—a type of polling device. The study also explores the impact of concentration, sense of control and autotelic experience on students' perceived learning and satisfaction. Based on a survey of 204 undergraduate students who use clickers in the classroom, the findings show that balance of skill and challenge has a positive influence on students' concentration, sense of control and autotelic experience. Both feedback provided by clickers and goal clarity have a positive influence on concentration and sense of control, but do not influence the autotelic experience. Findings also corroborate the positive impact of concentration and sense of control experienced by students on perceived learning. Finally, autotelic experience predicts both perceived learning and satisfaction.
Health‐related quality of life outcomes from a contemporary prostate cancer registry in a large diverse population
Authors: Chien Gary W. , Slezak Jeff M. , Harrison Teresa N. , Jung Howard , Gelfond Joy S. , Zheng Chengyi , Wu Edward , Contreras Richard , Loo Ronald K. , Jacobsen Steven J. 
Published: April 2017

ObjectiveTo assess the health‐related quality of life (HRQoL) of patients with prostate cancer up to 24 months after treatment in a contemporary large diverse population.Patients and MethodsPatients with newly diagnosed prostate cancer from March 2011 to January 2014 in our healthcare system were included. The Expanded Prostate Cancer Index Composite (EPIC‐26) questionnaire was administered before treatment, and at 1, 3, 6, 12, 18, and 24 months after treatment up to November 2014 for all methods of treatment. The Kruskall–Wallis test was used to compare the distribution of each EPIC‐26 domain score at each time point, and mixed models were used to assess the overall scores over the period after treatment.ResultsIn all, 5 727 patients were included. There were data for 3 422, 2 329, 2 017, 1 922, 1 772, 1 260, and 837 patients before treatment, and at 1, 3, 6, 12, 18, and 24 months after treatment, respectively. At 1 month, bowel scores were the lowest for patients that had had radiation therapy, and urinary irritative symptoms were the lowest for those who had had brachytherapy. There were sexual function declines for all the treatment methods, with surgery having the steepest decline; open radical prostatectomy (ORP) had a greater decline than robot‐assisted laparoscopic prostatectomy (RALP). Patients who underwent RALP had a better return of sexual function, approaching that of brachytherapy and radiation therapy at 24 months. Urinary incontinence (UI) also declined the most in surgical patients, with RALP patients improving slightly more than ORP patients at 12–24 months.ConclusionsPatients' HRQoL after prostate cancer treatment varies by treatment method. Notably, sexual function recovers most for RALP patients. UI remains worse at 24 months after surgery, compared to other methods of prostate cancer treatment.
Lifestyle use of drugs by healthy people for enhancing cognition, creativity, motivation and pleasure
Authors: d'Angelo L‐S Camilla , Savulich George , Sahakian Barbara J 
Published: April 2017

Today, there is continued, and in some cases growing, availability of not only psychoactive substances, including treatments for mental health disorders such as cognitive enhancers, which can enhance or restore brain function, but also ‘recreational’ drugs such as novel psychoactive substances (NPS). The use of psychoactive drugs has both benefits and risks: whilst new drugs to treat cognitive symptoms in neuropsychiatric or neurodegenerative disorders could have great benefits for many patient groups, the increasing ease of accessibility to recreational NPS and the increasing lifestyle use of cognitive enhancers by healthy people means that the effective management of psychoactive substances will be an issue of increasing importance. Clearly, the potential benefits of cognitive enhancers are large and increasingly relevant, particularly as the population ages, and for this reason, we should continue to devote resources to the development of cognitive enhancers as treatments for neurodegenerative diseases and psychiatric disorders, including Alzheimer's disease, attention deficit hyperactivity disorder and schizophrenia. However, the increasing use of cognitive enhancers by healthy individuals raises safety, ethical and regulatory concerns, which should not be ignored. Similarly, understanding the short‐ and long‐term consequences of the use of NPS, as well as better understanding the motivations and profiles of users could promote more effective prevention and harm reduction measures.Linked ArticlesThis article is part of a themed section on Pharmacology of Cognition: a Panacea for Neuropsychiatric Disease? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.19/issuetoc
Neural tube defects: Risk factors and preventive measures
Authors: Kondo Atsuo , Matsuo Takuya , Morota Nobuhito , Kondo Atsuya S. , Okai Ikuyo , Fukuda Hiromi 
Published: April 2017

AbstractFor the last 25 years, it has been proven that the occurrence or recurrence of neural tube defects can be prevented with the administration of folic acid before and early pregnancy. At present, over 80 countries in the world, except Japan, have mandated the fortification of wheat flour and/or rice with folic acid, which has resulted in a significant reduction in the prevalence of neural tube defects. In 2000, the Japanese government recommended folic acid 400 μg daily for young women of childbearing age and women who are planning to conceive. In 2002, the government started to present information about the importance of folic acid in the development of fetuses in the Mother‐Child Health Booklet annually. Despite these endeavors, the prevalence of neural tube defects has remained unchanged. We discuss the risk factors of neural tube defects and propose preventive measures to decrease the number of neonates with neural tube defects. We believe that the government should implement the fortification of staple food with folic acid very soon, which will eventually decrease not only the neonatal mortality and morbidity, but also the economic burden on our health care system.
Understanding the effects of different social data on selecting priority conservation areas
Authors: Karimi Azadeh , Tulloch Ayesha I.T. , Brown Greg , Hockings Marc 
Published: April 2017

AbstractConservation success is contingent on assessing social and environmental factors so that cost‐effective implementation of strategies and actions can be placed in a broad social–ecological context. Until now, the focus has been on how to include spatially explicit social data in conservation planning, whereas the value of different kinds of social data has received limited attention. In a regional systematic conservation planning case study in Australia, we examined the spatial concurrence of a range of spatially explicit social values and land‐use preferences collected using a public participation geographic information system and biological data. We used Zonation to integrate the social data with the biological data in a series of spatial‐prioritization scenarios to determine the effect of the different types of social data on spatial prioritization compared with biological data alone. The type of social data (i.e., conservation opportunities or constraints) significantly affected spatial prioritization outcomes. The integration of social values and land‐use preferences under different scenarios was highly variable and generated spatial prioritizations 1.2–51% different from those based on biological data alone. The inclusion of conservation‐compatible values and preferences added relatively few new areas to conservation priorities, whereas including noncompatible economic values and development preferences as costs significantly changed conservation priority areas (48.2% and 47.4%, respectively). Based on our results, a multifaceted conservation prioritization approach that combines spatially explicit social data with biological data can help conservation planners identify the type of social data to collect for more effective and feasible conservation actions.
Interactive effects of nitrate concentrations and carbon dioxide on the stoichiometry, biomass allocation and growth rate of submerged aquatic plants
Authors: Dülger Emin , Heidbüchel Patrick , Schumann Tobias , Mettler‐Altmann Tabea , Hussner Andreas 
Published: April 2017

Abstract

The partial pressure of carbon dioxide (CO2) in freshwater ecosystems is likely to be affected by climate change, but little is known of its potential effects on aquatic plants when interacting with other stressors such as nitrate pollution.

We set a laboratory experiment to test the effects of CO2 and nitrate availability on growth, biomass allocation, chlorophyll content, and nitrogen, carbon and starch content in four species of submerged aquatic plants. Plants were grown under low CO2 (0.02 mm CO2 and 0.83 mm HCO3−) and high CO2 (0.33 mm CO2 and 0.54 mm HCO3−) at five nitrate concentrations (0.1, 0.5, 1, 2 and 4 mg N/L).

Growth rates were stimulated in all species by increasing nitrogen and CO2 availability. Leaf dry matter content (LDMC), leaf starch content and biomass allocation to roots increased with increasing CO2, but decreased with increasing nitrogen availability.

Leaf chlorophyll and nitrogen content in roots and leaves were significantly higher in the low than in the high CO2 treatments, and generally increased with increasing nitrogen availability. The starch content of leaves correlated positively with LDMC, but negatively with chlorophyll content.

There were strong interactive effects of CO2 and nitrogen availability on plant growth parameters, tissue nitrogen, chlorophyll and starch content. CO2 availability had a stronger effect on biomass allocation to roots than nitrogen. The effects of CO2 on LDMC, tissue nitrogen, starch and chlorophyll content were more pronounced under low than under high nitrogen concentration.

Our laboratory study suggests that changes in the composition of dissolved inorganic carbon driven by climate change can interact with environmental stressors such as nitrate pollution and affect growth, biomass allocation and physiology of submerged aquatic plants. This is likely to have significant implications for the structuring role of macrophytes in freshwater ecosystems.