bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vertical stratification of arctic microbial communities near potential hydrocarbon seepage off Cape Dyer, Nunavut
Authors: Ji Meng , Ortmann Alice C. , Wohlgeschaffen Gary , Jauer Chris , Azetsu-Scott Kumiko 
Published: October 2024

AbstractClimate change disproportionately affects the Arctic, where warming is up to four times greater than the global annual average experienced in southern regions. Baffin Bay in the Canadian Arctic Archipelago is an ecologically and biologically significant area that will likely experience an increase in marine vessel traffic as a result of consistent declines in annual sea ice coverage. Along the western coast of Baffin Bay is known to be a region of active, natural hydrocarbon seeps where elevated levels of methane have been detected in previous surveys. Petroleum hydrocarbons released from the seafloor can fuel microbial production and shape the baseline microbiome. Establishing a microbial baseline is highly valuable as it contributes to a fundamental understanding of the existing microbial diversity that may be impacted in the future by anthropogenic stressors. In this study, 16S and 18S rRNA gene amplicon sequencing surveys revealed that the vertical stratification of the water column is largely driven by differences in depth, temperature, salinity, and inorganic nutrient concentrations. Chemical analysis provides further support that active petrogenic methane seepage occurs around Cape Dyer but not in areas targeted in this study. Presence of n-alkanes and toluene in association with hydrocarbon-synthesizing phytoplankton suggests biogenic production of these compounds. These findings provide a baseline for future environmental monitoring assessments to evaluate how the prokaryotic and eukaryotic microbiome may be impacted by ongoing climate change and anthropogenic stressors in western Baffin Bay.
Behandlung einer „frozen shoulder“ nach dem Fasziendistorsionsmodell
Authors: Boss Roman , Bangerter Christian 
Published: October 2024

Zusammenfassung
Hintergrund
Die Diagnose „frozen shoulder“ beschreibt ein Phänomen der schmerzhaft eingeschränkten Schulterbeweglichkeit. Bis heute bleiben die dem Beschwerdebild zugrunde liegenden Pathomechanismen nur teilweise verstanden und es wird kontrovers diskutiert, wie eine effektive Behandlungsstrategie aussehen soll.

Ziel
Ziel dieser Einzelfallstudie ist es, das konkrete Vorgehen nach dem Fasziendistorsionsmodell (FDM) bei der Befundaufnahme und der Behandlung eines Patienten mit einer „frozen shoulder“ aufzuzeigen und die eingesetzten Untersuchungs- und Behandlungstechniken zu diskutieren.

Patient und Methoden
Der 51-jährige Patient litt seit etwa 6 Monaten an starken Schulterschmerzen und Bewegungseinschränkungen. Im Rahmen der körperlichen Untersuchung konnten seine Beschwerden mit dem „pinching“ (Kneifen) des subkutanen Bindegewebes reproduziert werden und ein klarer Seitenunterschied ließ sich ausmachen. Die Beschwerden wurden anhand des FDM auf Fasziendistorsionen zurückgeführt und mit entsprechenden Techniken behandelt.

Ergebnisse
Insgesamt wurden 18 halbstündige Therapiesitzungen über einen Zeitraum von 5 Monaten durchgeführt. Dabei konnten die Schmerzen und Einschränkungen im Alltag des Patienten stark reduziert werden und die Schulterbeweglichkeit verbesserte sich deutlich.

Schlussfolgerung
Dieser Fallbericht zeigt, dass ein Patient mit der Diagnose „frozen shoulder“ mittels FDM effektiv behandelt werden konnte. Dabei spielte das subkutane Bindegewebe sowohl im Rahmen der Befundaufnahme als auch bei der Behandlung eine wichtige Rolle.
Exome variant prioritization in a large cohort of hearing-impaired individuals indicates IKZF2 to be associated with non-syndromic hearing loss and guides future research of unsolved cases
Authors: Velde Hedwig M. , Vaseghi-Shanjani Maryam , Smits Jeroen J. , Ramakrishnan Gayatri , Oostrik Jaap , Wesdorp Mieke , Astuti Galuh , Yntema Helger G. , Hoefsloot Lies , Lanting Cris P. , Huynen Martijn A. , Lehman Anna , Turvey Stuart E. ,   DOOFNL Consortium, Aten E. , van den Boogaard M. J. , Cals F. L. J. , van Dooren M. F. , Ebbens F. A. , Feenstra I. , Free R. H. , de Gier H. H. W. , Goderie T. P. M. , Haer-Wigman L. , Hellingman K. , Hoefsloot E. H. , Hof J. R. , van de Kamp J. , Kant S. G. , Wassink-Ruiter J. S. Klein , Kremer H. , Kriek M. , Lachmeijer A. M. A. , Lanting C. P. , Maas S. M. , Merkus P. , Pennings R. J. E. , Plomp A. , Ropers F. G. , Rotteveel L. J. C. , van der Schroeff M. P. , Smit A. L. , Smits J. J. , Vernimmen V. , Widdershoven J. C. C. , Yntema H. G. , Pennings Ronald J. E. , Kremer Hannie 
Published: October 2024

AbstractAlthough more than 140 genes have been associated with non-syndromic hereditary hearing loss (HL), at least half of the cases remain unexplained in medical genetic testing. One reason is that pathogenic variants are located in ‘novel’ deafness genes. A variant prioritization approach was used to identify novel (candidate) genes for HL. Exome-wide sequencing data were assessed for subjects with presumed hereditary HL that remained unexplained in medical genetic testing by gene-panel analysis. Cases in group AD had presumed autosomal dominantly inherited HL (n = 124), and in group AR, presumed autosomal recessive HL (n = 337). Variants in known and candidate deafness genes were prioritized based on allele frequencies and predicted effects. Selected variants were tested for their co-segregation with HL. Two cases were solved by variants in recently identified deafness genes (ABHD12, TRRAP). Variant prioritization also revealed potentially causative variants in candidate genes associated with recessive and X-linked HL. Importantly, missense variants in IKZF2 were found to co-segregate with dominantly inherited non-syndromic HL in three families. These variants specifically affected Zn2+-coordinating cysteine or histidine residues of the zinc finger motifs 2 and 3 of the encoded protein Helios. This finding indicates a complex genotype–phenotype correlation for IKZF2 defects, as this gene was previously associated with non-syndromic dysfunction of the immune system and ICHAD syndrome, including HL. The designed strategy for variant prioritization revealed that IKZF2 variants can underlie non-syndromic HL. The large number of candidate genes for HL and variants therein stress the importance of inclusion of family members for variant prioritization.
Integration von hybriden automatisierten Flotten in Österreich
Authors: Reinthaler Martin , Hu Bin , Watzinger Hannes , Feichtinger Christoph , Neubauer Matthias , Schildorfer Wolfgang 
Published: October 2024

ZusammenfassungDie Einführung hybrider automatisierter Flotten bietet großes Potenzial für die Verbesserung der Mobilitäts- und Transportsysteme. Der vorliegende Artikel zeigt die wesentlichen Dimensionen und Herausforderungen auf, die bei der Integration dieser Technologien zu beachten sind. Die Multidimensionalität der Einsatzszenarien – Anwendungsfall, Fahrzeugkategorie, Automatisierungsgrad und Assistenzsysteme – spielt eine entscheidende Rolle bei der Gestaltung einer heterogenen Flotte und beeinflusst deren Effizienz und Sicherheit maßgeblich. Der Schwerpunkt des Artikels ist die Gestaltungsaspekte und Anforderungen an die Leitstellen für hybride Flotten. Diese verdeutlicht, dass eine nahtlose Integration von automatisierten Fahrzeugen in bestehende Flottenmanagementsysteme notwendig ist. Besonders kleine Länder wie Österreich stehen vor der Herausforderung, eine Abhängigkeit von OEMs und Tech-Giganten zu vermeiden. Durch die Stärkung lokaler Kompetenzen und die Förderung von Kooperationen zwischen nationalen Akteuren soll die unabhängige und innovative Entwicklung vorangetrieben werden.
A synthesis of machine learning and internet of things in developing autonomous fleets of heterogeneous unmanned aerial vehicles for enhancing the regenerative farming cycle
Authors: Almalki Faris A. , Angelides Marios C. 
Published: October 2024

AbstractThe use of Unmanned Aerial Vehicles (UAVs) for agricultural monitoring and management offers additional advantages over traditional methods, ranging from cost reduction to environmental protection, especially when they utilize Machine Learning (ML) methods, and Internet of Things (IoT). This article presents an autonomous fleet of heterogeneous UAVs for use in regenerative farming the result of a synthesis of Deep Reinforcement Learning (DRL), Ant Colony Optimization (ACO) and IoT. The resulting aerial framework uses DRL for fleet autonomy and ACO for fleet synchronization and task scheduling inflight. A 5G Multiple Input Multiple Output-Long Range (MIMO-LoRa) antenna enhances data rate transmission and link reliability. The aerial framework, which has been originally prototyped as a simulation to test the concept, is now developed into a functional proof-of-concept of autonomous fleets of heterogeneous UAVs. For assessing performance, the paper uses Normalized Difference Vegetation Index (NDVI), Mean Squared Error (MSE) and Received Signal Strength Index (RSSI). The 5G MIMO-LoRa antenna produces improved results with four key performance indicators: Reflection Coefficient (S11), Cumulative Distribution Functions (CDF), Power Spectral Density Ratio (Eb/No), and Bit Error Rate (BER).
Facial trauma education in radiology: using surgeon feedback as the benchmark for success
Authors: Malouf William T. , Kondaveeti Geeth , Phillips Jacline G. , Patel Kunjan , Hall Justin A. , Fourrier Torrey L. , May Nelson , Meegalla Nuwan T. , Reger Kevin J. , Runyan Christopher M. , Hiatt Kevin D. 
Published: October 2024

Abstract
Rationale and objectives
Interpreting CT studies of facial trauma is challenging, and there are often substantial differences in the characterization of complex facial trauma between radiologists and surgeons. We designed a collaborative multidisciplinary project to reconcile differences in facial fracture interpretation through an educational intervention. The effectiveness of this intervention was evaluated through surgeon feedback on radiology reports.

Materials and methods
Radiology residents, neuroradiology fellows, and neuroradiology attendings were recruited as participants at a single tertiary care academic center. Otolaryngology residents were recruited as evaluators. Participants completed surveys and provided preliminary reports for example cases of facial trauma before and after attending an educational session. Evaluators performed a blinded review of these preliminary reports based on ideal reports developed by surgical and neuroradiology attendings.

Results
26 participants (20 residents, 1 neuroradiology fellow, 5 neuroradiology attendings) completed the study. Six otolaryngology residents participated as evaluators. To assess interrater reliability, three evaluators graded a shared set of 15 reports and demonstrated substantial agreement with a Kendall’s W of 0.71. Participants demonstrated significant improvement in overall report accuracy, clarity, and organization. In subunit analysis, there were significant improvements in reporting Le Fort, nasoseptal, and nasoorbitoethmoid fractures. No significant improvements occurred in the reporting of upper face, zygomaticomaxillary complex, or mandibular fractures. In contrast, survey analysis demonstrated significantly improved confidence in interpreting trauma involving all facial subunits.

Conclusion
Compared with survey results, surgeon assessment of radiology reports better demonstrated areas of improvement after an educational intervention. A multidisciplinary approach to assessing educational efforts may better evaluate the practical effectiveness of educational interventions.
MRI recovery with self-calibrated denoisers without fully-sampled data
Authors: Shafique Muhammad , Liu Sizhuo , Schniter Philip , Ahmad Rizwan 
Published: October 2024

Abstract

Objective
Acquiring fully sampled training data is challenging for many MRI applications. We present a self-supervised image reconstruction method, termed ReSiDe, capable of recovering images solely from undersampled data.

Materials and methods
ReSiDe is inspired by plug-and-play (PnP) methods, but unlike traditional PnP approaches that utilize pre-trained denoisers, ReSiDe iteratively trains the denoiser on the image or images that are being reconstructed. We introduce two variations of our method: ReSiDe-S and ReSiDe-M. ReSiDe-S is scan-specific and works with a single set of undersampled measurements, while ReSiDe-M operates on multiple sets of undersampled measurements and provides faster inference. Studies I, II, and III compare ReSiDe-S and ReSiDe-M against other self-supervised or unsupervised methods using data from T1- and T2-weighted brain MRI, MRXCAT digital perfusion phantom, and first-pass cardiac perfusion, respectively.

Results
ReSiDe-S and ReSiDe-M outperform other methods in terms of peak signal-to-noise ratio and structural similarity index measure for Studies I and II, and in terms of expert scoring for Study III.

Discussion
We present a self-supervised image reconstruction method and validate it in both static and dynamic MRI applications. These developments can benefit MRI applications where the availability of fully sampled training data is limited.
Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration
Authors: Trisal Anchal , Singh Abhishek Kumar 
Published: October 2024

AbstractAging, an inevitable physiological process leading to a progressive decline in bodily functions, has been an abundantly researched domain with studies attempting to slow it down and reduce its debilitating effects. Investigations into the cellular and molecular pathways associated with aging have allowed the formulation of therapeutic strategies. Of these, caloric restriction (CR) has been implicated for its role in promoting healthy aging by modulating key molecular targets like Insulin/IGF-1, mTOR, and sirtuins. However, CR requires dedication and commitment to a strict regimen which poses a difficulty in maintaining consistency. To maneuver around cumbersome diets, Caloric Restriction Mimetics (CRMs) have emerged as promising alternatives by mimicking the beneficial effects of CR. This review elucidates the molecular foundations enabling CRMs like rapamycin, metformin, resveratrol, spermidine, and many more to function as suitable anti-aging molecules. Moreover, it explores clinical trials (retrieved from the clinicaltrials.gov database) aimed at demonstrating the efficacy of CRMs as effective candidates against age-related neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.
Open source platform for Estonian speech transcription
Authors: Olev Aivo , Alumäe Tanel 
Published: October 2024

AbstractThis paper presents our progress in developing and maintaining a public speech and speaker recognition platform for the Estonian language. The platform consists of a speech processing pipeline and a web-based user interface for end-users, offering transcript post-editing functionality. It is offered for free as a public service and is in active use. The service provides significantly higher speech recognition accuracy than commercial alternatives. We discuss the switch to a workflow management system and how it has improved the core speech processing pipeline. The core systems behind the platform have been made available as open-source code and deployed internally by multiple public and private institutions.
Speed of Sound Measurements of Binary Mixtures of 1,1-Difluoroethylene (R-1132a) + Propane and Derived Speed of Sound of Pure R-1132a
Authors: Rowane Aaron J. , Perkins Richard A. 
Published: October 2024

Abstract
Speed of sound data, measured using a dual-path pulse-echo instrument, are reported for three binary mixtures of 1,1-difluoroethylene (R-1132a) with propane at temperatures ranging from 230 to 345 K and pressures ranging from slightly above the bubble curve to a maximum pressure of 50 MPa. Significant attenuation of the pulse-echo signals was observed for measurements on pure R-1132a. Therefore, the R-1132a sample was doped with propane at mole fractions ranging from 0.0274 to 0.0887 and the propane + R-1132a mixture data was used to derive sound speeds for pure R-1132a. The data were compared to a preliminary equation of state for R-1132a, and deviations ranged from 2 % to 8 %. This demonstrates that the preliminary R-1132a EoS needs to be refit to better represent the speed of sound.
Shear bond strength between dental adhesive systems and an experimental niobium-based implant material
Authors: Brümmer N. , Klose C. , Schleich J-T. , Maier H. J. , Eisenburger M. , Stiesch M. , Pott P.-C. 
Published: October 2024

AbstractThis study aimed to investigate adhesive shear bond strength (SBS) on an ultrafine-grained niobium alloy (UFG-Nb) that is a potential dental implant material. SBS of three adhesive systems combined with three composites to UFG-Nb was compared to corresponding SBS to Ti-6Al-4V and to zirconia. Specimens of the substrates UFG-Nb, Ti-6Al-4V and zirconia with plane surfaces were sandblasted with Al2O3, cleaned and dried. Three adhesive systems (Futurabond U, Futurabond M + , Futurabond M + DCA; all VOCO GmbH, Cuxhaven, Germany) were applied each on specimens of each substrate and light cured. One composite (BifixSE, BifixQM, GrandioSO; all VOCO GmbH) was applied and light cured resulting in 27 groups (n = 10) for all substrate-adhesive-composite-combinations. SBS was measured after 24 h of storage. To simulate aging equally prepared specimens underwent 5000 thermocycles before SBS measurement. There was no significant difference in SBS within the non-aged groups. Among the artificially aged groups, GrandioSO-groups showed a greater variance of SBS than the other composites. All significant differences of corresponding UFG-Nb-, Ti-6Al-4V- and zirconia-groups with same adhesive-composite-combination (ACC) were observed between UFG-Nb and zirconia or Ti-6Al-4V and zirconia but never between the two metallic substrates. The similarity between these materials might show in their adhesive bonding behavior. As there were no differences comparing corresponding groups prior to and after artificial aging, it can be concluded that aging does not affect SBS to UFG-Nb, Ti-6Al-4V and zirconia using the tested ACCs. Adhesive bonding of established ACCs to UFG-Nb is possible resulting in SBS comparable to those on Ti-6Al-4V and zirconia surfaces.
Graphical Abstract
Youth Intimate Partner Femicide: Identification of Factors Specific to Femicide Against Adolescent and Young Adult Victims
Authors: Caman Shilan , Skott Sara 
Published: October 2024

Abstract
Objectives
Intimate partner femicide (IPF) is a public health issue with far-reaching and extreme consequences. As previous research mainly has treated IPF as an adult phenomenon, young victims of such violence have been rendered invisible. Consequently, youth IPF is not well understood and little is known about factors specific to IPF against adolescent and young adult females.

Purpose
The aim of this study is to examine factors related to youth IPF (≤ 25 years) and to compare cases of youth IPF with cases of adult IPF (≥ 26 years) regarding these factors. Victim and perpetrator characteristics are explored, as well as factors related to the relationship and circumstances of the crimes.

Methods
This epidemiological study is based on a national dataset that involves all homicides in Sweden between 1990 and 2017. Incidents of male-perpetrated femicide in which the perpetrator and victim were or had been in an intimate relationship were analyzed. Descriptive and multivariate analyses with odds ratios (OR) were conducted in order to make group comparisons between young (n = 62) and adult (n = 320) IPF.

Results
Our study reveals interesting differences between youth and adult IPF, in which youth IPF is more likely to be motivated by relationship break-up, involve strangulation of the victim and drug use.

Conclusions
Our study sheds light on the factors and circumstances that play an important role in youth IPF, and could be fruitful to target in future prevention and intervention efforts that aim to combat severe violence against adolescent and young adult females.
Intramammary Labeling of Epithelial Cell Division
Authors: Machiela Maia N. , Hovey Russell C. 
Published: October 2024

AbstractThymidine analogs such as ethynyl deoxyuridine (EdU) or bromodeoxyuridine (BrdU) can be used to label mitosis of mammary epithelial cells (MEC) and to quantify their proliferation. However, labeling cells in larger animals requires considerable amounts of chemical that can be costly and hazardous. We developed a strategy to infuse EdU into the mammary glands of ewes to directly label mitotic MEC. First, each udder half of nulliparous ewes (n = 2) received an intramammary infusion of one of four different concentrations of EdU (0, 0.1, 1.0 or 10 mM) which was compared to BrdU IV (5 mg/kg) 24 h later. Tissues were analyzed by immunofluorescent histochemistry to detect EdU, BrdU, and total MEC. Of the EdU doses tested, 10 mM EdU yielded the greatest labeling index, while a proportion of MEC were labeled by both EdU and BrdU. We next sought to establish whether intramammary labeling could detect the induction of mitosis after exposure to exogenous estrogen and progesterone (E + P). We first infused EdU (10 mM) into the right udder half of ewes (n = 6) at t 0, followed by thymidine (100 mM) 24 h later to prevent further labeling. Three ewes were then administered E + P for 5 d, while n = 3 ewes served as controls. On d 5, EdU was infused into the left udder half of all mammary glands alongside BrdU IV (5 mg/kg). By the time of necropsy 24 h later an average MEC labeling index of 2.9% resulted from EdU delivered at t 0. In the left half of the udder on d 5, CON glands had a final EdU labeling index of 3.4% while glands exposed to E + P had a labeling index of 4.6% (p = 0.05). The corresponding degree of labeling with BrdU was 5.6% in CON glands, and 12% following E + P (p < 0.001). Our findings reveal that intramammary labeling is an efficient and cost-effective method for single- and dual-labeling of cell division in the mammary glands.
SBIR mills and the U.S. Department of Defense
Authors: Link Albert N. , Swann Christopher A. 
Published: October 2024

AbstractMultiple winners of Small Business Innovation Research (SBIR) awards have come under scrutiny by some in the public sector who claim that so-called SBIR mills fail to commercialize from their funded research. We examine this issue using data on a sample of SBIR awards awarded between 1992 and 2001. Consistent with the critique, we find a negative association between the overall number of previous SBIR awards and commercialization from a current SBIR-funded project. However, when we consider the number of previous SBIR awards related to the current project’s technology, we find a positive association thus suggesting previous technologically related awards increase the probability of commercialization. We extend the analysis beyond commercialization to patents and scientific publications related to the current award and find similar patterns of results. Our results also reinforce the finding of others that multiple SBIR awards are a heterogeneous metric.