bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cover Image, Volume 66, Issue 10
Authors: Bregadiolli Bruna A , Ramanitra Hasina H , Ferreira Rodrigo Marques , Corcoles Laura , Gomes Milton S , Kang Lauren , Combe Craig MS , Silva Hugo Santos , Lavarda Francisco C , Bégué Didier , Dagron‐Lartigau Christine , Rocco Maria Luiza M , Luscombe Christine K , Olivati Clarissa A , Graeff Carlos FO , Hiorns Roger C 
Published: September 2017

The cover image, by Bruna A. Bregadiolli et al., is based on the Research Article Towards the synthesis of poly(azafulleroid)s: main chain fullerene oligomers for organic photovoltaic devices, DOI: 10.1002/pi.5419.
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Surface‐Engineering of Red Blood Cells as Artificial Antigen Presenting Cells Promising for Cancer Immunotherapy
Authors: Sun Xiaoqi , Han Xiao , Xu Ligeng , Gao Min , Xu Jun , Yang Rong , Liu Zhuang 
Published: September 2017

AbstractThe development of artificial antigen presenting cells (aAPCs) to mimic the functions of APCs such as dendritic cells (DCs) to stimulate T cells and induce antitumor immune responses has attracted substantial interests in cancer immunotherapy. In this work, a unique red blood cell (RBC)‐based aAPC system is designed by engineering antigen peptide‐loaded major histocompatibility complex‐I and CD28 activation antibody on RBC surface, which are further tethered with interleukin‐2 (IL2) as a proliferation and differentiation signal. Such RBC‐based aAPC‐IL2 (R‐aAPC‐IL2) can not only provide a flexible cell surface with appropriate biophysical parameters, but also mimic the cytokine paracrine delivery. Similar to the functions of matured DCs, the R‐aAPC‐IL2 cells can facilitate the proliferation of antigen‐specific CD8+ T cells and increase the secretion of inflammatory cytokines. As a proof‐of‐concept, we treated splenocytes from C57 mice with R‐aAPC‐IL2 and discovered those splenocytes induced significant cancer‐cell‐specific lysis, implying that the R‐aAPC‐IL2 were able to re‐educate T cells and induce adoptive immune response. This work thus presents a novel RBC‐based aAPC system which can mimic the functions of antigen presenting DCs to activate T cells, promising for applications in adoptive T cell transfer or even in direct activation of circulating T cells for cancer immunotherapy.
Cobalt Phosphide Coupled with Heteroatom‐Doped Nanocarbon Hybrid Electroctalysts for Efficient, Long‐Life Rechargeable Zinc–Air Batteries
Authors: Ahn Sung Hoon , Manthiram Arumugam 
Published: September 2017

AbstractMetal phosphides and heteroatom‐doped carbons have been regarded as promising candidates as bifunctional catalysts for oxygen evolution reaction (OER) and oxygen reduction reaction (ORR). However, both have suffered from stability issues during repeated ORR and OER operations in zinc–air batteries (ZABs). Herein, this study reports a versatile cobalt‐based hybrid catalyst with a 1D structure by integrating the metal‐organic framework‐derived conversion approach and an in situ crosslinking method. Among them, the 1D hybrid catalyst composed of ultrasmall cobalt phosphide nanoparticles supported by nitrogen‐, sulfur‐, phosphorus‐doped carbon matrix shows remarkable bifunctional activity close to that of the benchmark precious‐metal catalysts along with an excellent durability in the full potential range covering both the OER and ORR. The overall overpotential of the rechargeable ZABs can be greatly reduced with this bifunctional hybrid catalyst as an air‐electrode, and the cycling stability outperforms the commercial Pt/C catalyst. It is revealed that the cobalt phosphide nanoparticles are in situ converted to cobalt oxide under the accelerated conditions during OER (and/or ORR) of the ZABs and reduces the anodic current applied to the carbon. This contributes to the stability of the carbon material and in maintaining the high initial catalytic properties of the hybrid catalyst.
Children's Reading in Low‐Income Countries
Authors: Wagner Daniel A. 
Published: September 2017

AbstractChildren around the world, especially in low‐income countries, lack equal opportunities to develop the early skills on which school‐based learning takes place. Indeed, global data show that there are hundreds of millions of children with very low reading scores, even after many of them have gone to school for two or more years. Current research has accelerated in the area of early grade reading, as well as in language of instruction. Multiple studies and interventions have suggested innovative directions to support children's reading among the most marginalized groups. The 2030 United Nations Sustainable Development Goals, along with other global initiatives, are poised to make a major positive difference for such children in the coming years. A renewed focus on early reading worldwide and among the poor is part of what has been called the “learning as development” agenda.
Supporting Young Writers With Award‐Winning Books
Authors: MacKay Kathryn Lake , Ricks Paul H. , Young Terrell A. 
Published: September 2017

AbstractThis article presents a way to use award‐winning books as mentor texts for very young writers. Books were selected as mentor texts from the winners of the Australian Early Childhood Children's Book of the Year Award and the American Theodor Seuss Geisel Award. The authors explain the value of using award‐winning texts in the classroom and describe the respective processes by which the award‐winning books are chosen. Sections of exemplary texts are highlighted to demonstrate how they can be used to show young writers examples of circular text structure, descriptive language, print manipulation, punctuation, and dialogue.
Low Velocity Layer Characterization in the Niger Delta: Implications for Seismic Reflection Data Quality
Authors: Opara A. I. , Agoha C. C. , Okereke C. N. , Adiela U. P. , Onwubuariri C. N. , Okpono J. O. , Nosiri O. P. 
Published: September 2017

ABSTRACT
The problems of poor data quality and statics in seismic surveys have been attributed to lack of proper understanding of the low velocity layer characteristics of the area from which such data was acquired. Downhole seismic refraction survey was therefore conducted at twenty (20) borehole locations within parts of Niger Delta, Nigeria to determine the low velocity layer characteristics of the area using the Geometrics Stratavisor NZ11 instrument. The data was processed using Udysys software with spatial representation of the results presented. Static corrections were carried out on reflection seismic data acquired from the study area using Geoscribe II software to determine the effects of the low velocity layer on reflection seismic data in the area. Results of the study revealed that the velocity of the low velocity layer ranged between 144 and 996m/s with a regional average of 407m/s. The thickness of the low velocity layer varied between 3.0 and 9.6m with a mean value of 5.0m. Similarly, the velocity of the consolidated layer ranged between 1449 and 1812m/s with a mean value of 1738m/s. Results of the static correction carried out on the seismic reflection data revealed a substantial improvement in the resolution of the data after static correction. Based on these findings, it is therefore, recommended that shots for reflection seismic survey should be located at a minimum depth of 9.6m in the area to eliminate the effects associated with the low velocity layer.
MRPN Technique for Assessment of Working Risks in Underground Coal Mines
Authors: Behraftar S. , Hossaini S. M. F. , Bakhtavar E. 
Published: September 2017

ABSTRACT
Accidents in underground collieries, under geological and geotechnical uncertainties, cause some irrecoverable consequences for workers. Recognizing and studying the effective factors in the occurrence of such accidents have a very crucial impact on improving worker safety and reducing mining costs. This paper introduces a new and beneficial technique named “modified risk priority number (MRPN)” for recognizing and assessing those risks which may cause working accidents in Iranian underground collieries. The available qualitative data from the mines was quantified using standard tables established for risk assessment. The technique was exemplified using data from mine accidents in Kerman and East-Alborz regions. Roof-fall was found to be the most significant risk factor in the mines that were investigated.
Assessment of Uranium in Correlation with Physico-chemical Properties of Drinking Water of Northern Rajasthan
Authors: Mittal Sudhir , Rani Asha , Mehra Rohit , Balaram V. , Satyanarayanan M. , Sawant S. S. 
Published: September 2017

ABSTRACT
In the present study, analysis of 238U concentration in 40 drinking water samples collected from different locations of Jodhpur, Nagaur, Bikaner and Jhunjhunu districts of Rajasthan, India has been carried out by using high resolution inductively coupled plasma mass spectroscopy (HR-ICP-MS) technique. The water samples were taken from hand pumps and tube wells having depths ranging from 50 to 800 feet. The measured uranium concentration lies in the range from 0.89 to 166.89 μg l−1 with the mean value of 31.72 μg l−1. The measured uranium content in twelve water samples was found to be higher than the safe limit of 30 μg l−1 as recommended by World Health Organization (WHO, 2011) and US Environmental Protection Agency (USEPA, 2011). Radiological risk calculated in the form of annual effective dose estimated from annual uranium intake ranges from 0.66 to 138.63 μSv y−1 with the mean value of 26.28 μSv y−1. The annual effective dose in two drinking water samples was found to be greater than WHO (2004) recommended level of 100 μSv y−1. Chemical risk calculated in the form of lifetime average daily dose (LAAD) estimated from the water samples varies from 0.02 to 4.57 μg kg−1 d−1 with the mean value of 0.87 μg kg−1 d−1. The lifetime average daily dose (LAAD) of ten drinking water samples was found to be greater than WHO (2011) recommended level of 1 μg kg−1 d−1. The corresponding values of hazard quotient of 48% water samples were found to be greater than unity. A good positive correlation of uranium concentration with total dissolved solids (TDS) and conductance has been observed. However no correlation of uranium concentration with pH was observed. The results revels that uranium concentration in drinking water samples of the study area can cause radiological and chemical threat to the inhabitants.
An Integrative Review of the Hands‐Free Technique in the OR
Authors: Linzer Pamela B. , Clarke Sean P. 
Published: September 2017

AbstractSharps injury rates are proportionally higher in perioperative areas than in other practice settings. The hands‐free technique (HFT) has been shown to decrease the hazards of sharps injuries when passing sharps during surgery. We reviewed and synthesized research studies regarding compliance with the HFT and factors facilitating its use using a key word search of online databases and a secondary search of references. We reviewed English language studies published since 2001 regarding HFT compliance rates or related factors using the Johns Hopkins Nursing Evidence‐Based Practice Model and Guidelines. We found 14 articles reporting a wide range of HFT compliance rates (ie, 5% to 84%), which identified that a number of organizational factors and health care workers’ perceptions of infection risks influenced the use of the HFT.
Neural correlates of affective and non-affective cognition in obsessive compulsive disorder: A meta-analysis of functional imaging studies
Authors: Rasgon A. , Lee W.H. , Leibu E. , Laird A. , Glahn D. , Goodman W. , Frangou S. 
Published: September 2017

AbstractObsessive compulsive disorder (OCD) is characterized by intrusive thoughts and repetitive ritualistic behaviors and has been associated with diverse functional brain abnormalities. We sought to synthesize current evidence from functional magnetic resonance imaging (fMRI) studies and examine their alignment to pathogenetic models of OCD. Following systematic review, we identified 54 task-fMRI studies published in the last decade comparing adults with OCD (n = 1186) to healthy adults (n = 1159) using tasks of affective and non-affective cognition. We used voxel-based quantitative meta-analytic methods to combine primary data on anatomical coordinates of case-control differences, separately for affective and non-affective tasks. We found that functional abnormalities in OCD cluster within cortico-striatal thalamic circuits. Within these circuits, the abnormalities identified showed significant dependence on the affective or non-affective nature of the tasks employed as circuit probes. In studies using affective tasks, patients overactivated regions involved in salience, arousal and habitual responding (anterior cingulate cortex, insula, caudate head and putamen) and underactivated regions implicated in cognitive and behavioral control (medial prefrontal cortex, posterior caudate). In studies using non-affective cognitive tasks, patients overactivated regions involved in self-referential processing (precuneus, posterior cingulate cortex) and underactivated subcortical regions that support goal-directed cognition and motor control (pallidum, ventral anterior thalamus, posterior caudate). The overall pattern suggests that OCD-related brain dysfunction involves increased affective and self-referential processing, enhanced habitual responding and blunted cognitive control.
Prognostic implications of abnormalities of chromosome 13 and the presence of multiple cytogenetic high-risk abnormalities in newly diagnosed multiple myeloma
Authors: Binder M , Rajkumar S V , Ketterling R P , Greipp P T , Dispenzieri A , Lacy M Q , Gertz M A , Buadi F K , Hayman S R , Hwa Y L , Zeldenrust S R , Lust J A , Russell S J , Leung N , Kapoor P , Go R S , Gonsalves W I , Kyle R A , Kumar S K 
Published: September 2017

AbstractFluorescencein situhybridization evaluation is essential for initial risk stratification in multiple myeloma. While the presence of specific cytogenetic high-risk abnormalities (HRA) is known to confer a poor prognosis, less is known about the cumulative effect of multiple HRA. We studied 1181 patients with newly diagnosed multiple myeloma who received novel agents as first-line therapy. High-risk abnormalities were defined as t(4;14), t(14;16), t(14;20) and del(17p). There were 884 patients (75%) without any HRA and 297 patients (25%) with HRA, including 262 (22%) with one HRA and 35 (3%) with two HRA. The presence of one HRA (versus zero, hazard ratio (HR) 1.65, 95% confidence interval (CI) 1.32–2.05,p<0.001) and the presence of two HRA (versus zero, HR 3.15, 95% CI 2.00–4.96,p<0.001) were of prognostic significance after adjusting for other prognostic factors. Abnormalities of chromosome 13 were of prognostic significance independent of the established HRA: Monosomy 13 (HR 1.27, 95% CI 1.04–1.56,P=0.022) and del(13q) (HR 0.48, 95% CI 0.28–0.81,P=0.006) with opposite effects. Patients with HRA experienced worse overall survival suggesting a cumulative adverse effect of multiple HRA. Abnormalities of chromosome 13 were of prognostic significance after adjusting for other prognostic factors.
CXorf48 is a potential therapeutic target for achieving treatment-free remission in CML patients
Authors: Matsushita M , Ozawa K , Suzuki T , Nakamura M , Nakano N , Kanchi S , Ichikawa D , Matsuki E , Sakurai M , Karigane D , Kasahara H , Tsukamoto N , Shimizu T , Mori T , Nakajima H , Okamoto S , Kawakami Y , Hattori Y 
Published: September 2017

AbstractAlthough the introduction of tyrosine kinase inhibitors (TKIs) has improved overall survival of patients with chronic myeloid leukemia (CML), about half of the patients eventually relapse after cessation of TKIs. In contrast, the remainder of the patients maintain molecular remission without TKIs, indicating that the patients’ immune system could control proliferation of TKI-resistant leukemic stem cells (LSCs). However, the precise mechanism of immunity against CML-LSCs is not fully understood. We have identified a novel immune target, CXorf48, expressed in LSCs of CML patients. Cytotoxic T cells (CTLs) induced by the epitope peptide derived from CXorf48 recognized CD34+CD38− cells obtained from the bone marrow of CML patients. We detected CXorf48-specific CTLs in the peripheral blood mononuclear cells from CML patients who have discontinued imatinib after maintaining complete molecular remission for more than 2 years. Significantly, the relapse rate of CXorf48-specific CTL-negative patients was 63.6%, compared to 0% in CXorf48-specific CTL-positive patients. These results indicate that CXorf48 could be a promising therapeutic target of LSCs for immunotherapy to obtain durable treatment-free remission in CML patients.
On the role of initial velocities in pair dispersion in a microfluidic chaotic flow
Authors: Afik Eldad , Steinberg Victor 
Published: September 2017

AbstractChaotic flows drive mixing and efficient transport in fluids, as well as the associated beautiful complex patterns familiar to us from our every day life experience. Generating such flows at small scales where viscosity takes over is highly challenging from both the theoretical and engineering perspectives. This can be overcome by introducing a minuscule amount of long flexible polymers, resulting in a chaotic flow dubbed ‘elastic turbulence’. At the basis of the theoretical frameworks for its study lie the assumptions of a spatially smooth and random-in-time velocity field. Previous measurements of elastic turbulence have been limited to two-dimensions. Using a novel three-dimensional particle tracking method, we conduct a microfluidic experiment, allowing us to explore elastic turbulence from the perspective of particles moving with the flow. Our findings show that the smoothness assumption breaks already at scales smaller than a tenth of the system size. Moreover, we provide conclusive experimental evidence that ‘ballistic’ separation prevails in the dynamics of pairs of tracers over long times and distances, exhibiting a memory of the initial separation velocities. The ballistic dispersion is universal, yet it has been overlooked so far in the context of small scales chaotic flows.
Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood
Authors: Lukowski Samuel W. , Lloyd-Jones Luke R. , Holloway Alexander , Kirsten Holger , Hemani Gibran , Yang Jian , Small Kerrin , Zhao Jing , Metspalu Andres , Dermitzakis Emmanouil T. , Gibson Greg , Spector Timothy D. , Thiery Joachim , Scholz Markus , Montgomery Grant W. , Esko Tonu , Visscher Peter M. , Powell Joseph E. 
Published: September 2017

AbstractTranscript co-expression is regulated by a combination of shared genetic and environmental factors. Here, we estimate the proportion of co-expression that is due to shared genetic variance. To do so, we estimated the genetic correlations between each pairwise combination of 2469 transcripts that are highly heritable and expressed in whole blood in 1748 unrelated individuals of European ancestry. We identify 556 pairs with a significant genetic correlation of which 77% are located on different chromosomes, and report 934 expression quantitative trait loci, identified in an independent cohort, with significant effects on both transcripts in a genetically correlated pair. We show significant enrichment for transcription factor control and physical proximity through chromatin interactions as possible mechanisms of shared genetic control. Finally, we construct networks of interconnected transcripts and identify their underlying biological functions. Using genetic correlations to investigate transcriptional co-regulation provides valuable insight into the nature of the underlying genetic architecture of gene regulation.
Prophage-triggered membrane vesicle formation through peptidoglycan damage in Bacillus subtilis
Authors: Toyofuku Masanori , Cárcamo-Oyarce Gerardo , Yamamoto Tatsuya , Eisenstein Fabian , Hsiao Chien-Chi , Kurosawa Masaharu , Gademann Karl , Pilhofer Martin , Nomura Nobuhiko , Eberl Leo 
Published: September 2017

AbstractBacteria release membrane vesicles (MVs) that play important roles in various biological processes. However, the mechanisms of MV formation in Gram-positive bacteria are unclear, as these cells possess a single cytoplasmic membrane that is surrounded by a thick cell wall. Here we use live cell imaging and electron cryo-tomography to describe a mechanism for MV formation in Bacillus subtilis. We show that the expression of a prophage-encoded endolysin in a sub-population of cells generates holes in the peptidoglycan cell wall. Through these openings, cytoplasmic membrane material protrudes into the extracellular space and is released as MVs. Due to the loss of membrane integrity, the induced cells eventually die. The vesicle-producing cells induce MV formation in neighboring cells by the enzymatic action of the released endolysin. Our results support the idea that endolysins may be important for MV formation in bacteria, and this mechanism may potentially be useful for the production of MVs for applications in biomedicine and nanotechnology.
Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
Authors: Item Flurin , Wueest Stephan , Lemos Vera , Stein Sokrates , Lucchini Fabrizio C. , Denzler Rémy , Fisser Muriel C. , Challa Tenagne D. , Pirinen Eija , Kim Youngsoo , Hemmi Silvio , Gulbins Erich , Gross Atan , O’Reilly Lorraine A. , Stoffel Markus , Auwerx Johan , Konrad Daniel 
Published: September 2017

AbstractNonalcoholic fatty liver disease is one of the most prevalent metabolic disorders and it tightly associates with obesity, type 2 diabetes, and cardiovascular disease. Reduced mitochondrial lipid oxidation contributes to hepatic fatty acid accumulation. Here, we show that the Fas cell surface death receptor (Fas/CD95/Apo-1) regulates hepatic mitochondrial metabolism. Hepatic Fas overexpression in chow-fed mice compromises fatty acid oxidation, mitochondrial respiration, and the abundance of mitochondrial respiratory complexes promoting hepatic lipid accumulation and insulin resistance. In line, hepatocyte-specific ablation of Fas improves mitochondrial function and ameliorates high-fat-diet-induced hepatic steatosis, glucose tolerance, and insulin resistance. Mechanistically, Fas impairs fatty acid oxidation via the BH3 interacting-domain death agonist (BID). Mice with genetic or pharmacological inhibition of BID are protected from Fas-mediated impairment of mitochondrial oxidation and hepatic steatosis. We suggest Fas as a potential novel therapeutic target to treat obesity-associated fatty liver and insulin resistance.
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
Authors: Müller-Fielitz Helge , Stahr Marcus , Bernau Mareike , Richter Marius , Abele Sebastian , Krajka Victor , Benzin Anika , Wenzel Jan , Kalies Kathrin , Mittag Jens , Heuer Heike , Offermanns Stefan , Schwaninger Markus 
Published: September 2017

AbstractThe hypothalamic–pituitary–thyroid (HPT) axis maintains circulating thyroid hormone levels in a narrow physiological range. As axons containing thyrotropin-releasing hormone (TRH) terminate on hypothalamic tanycytes, these specialized glial cells have been suggested to influence the activity of the HPT axis, but their exact role remained enigmatic. Here, we demonstrate that stimulation of the TRH receptor 1 increases intracellular calcium in tanycytes of the median eminence via Gαq/11 proteins. Activation of Gαq/11 pathways increases the size of tanycyte endfeet that shield pituitary vessels and induces the activity of the TRH-degrading ectoenzyme. Both mechanisms may limit the TRH release to the pituitary. Indeed, blocking TRH signaling in tanycytes by deleting Gαq/11 proteins in vivo enhances the response of the HPT axis to the chemogenetic activation of TRH neurons. In conclusion, we identify new TRH- and Gαq/11-dependent mechanisms in the median eminence by which tanycytes control the activity of the HPT axis.