bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dapagliflozin for peritoneal dialysis patients with chronic heart failure in Japan: study protocol for a multicenter, open-label randomized controlled trial (the jDAPA-PD study)
Authors: Tanaka Mototsugu , Ishizawa Masahiro , Terashima Ryohei , Hashimoto Atsushi , Tanaka Takahiro , Miyazawa Haruna , Tomita Yoshihiko , Watanabe Kazuki , Iguchi Akira , Yamazaki Hajime , Ogawa Asa , Iino Noriaki , Yamamoto Suguru 
Published: October 2024

Abstract

Background
The effects of dapagliflozin on patients with end-stage kidney disease (ESKD) and chronic heart failure (CHF) who are on peritoneal dialysis (PD) are not well understood. The jDAPA-PD is a proof-of-concept study designed to assess the efficacy and safety of dapagliflozin in such patients in Japan.
Methods/design
: This is a multicenter, open-label randomized controlled trial conducted on 40 patients with ESKD and CHF on maintenance PD, particularly those who have substantial residual kidney function. Patients who were recently on sodium–glucose cotransporter 2 inhibitors, hemodialysis, or treatment for peritonitis or those who have a daily urine volume of < 500 mL will be excluded from the study. Participants will be randomized in a 1:1 allocation to either the 10 mg dapagliflozin orally once daily or the standard treatment groups. The primary endpoint is the change in extracellular water from baseline to week 24, which will be measured by bioelectrical impedance analysis. The secondary endpoints are all-cause mortality, cardiovascular events, hospitalization, PD discontinuation, and changes in body composition, blood pressure, renal and cardiac function, brain natriuretic peptide, peritoneal function, PD regimen, and weekly fluid removal from baseline to week 24. The safety endpoints are adverse events and adverse drug reactions that occur during the study period.
Discussion
This study will determine whether the oral administration of 10 mg of dapagliflozin for 24 weeks is effective in fluid control for patients with CHF on PD. The study will also provide evidence of the safety data and multifaceted effects of dapagliflozin in patients on PD.
Trial registration
: jRCT1031230624 (registered on February 5, 2024)
Anatomical approach in magnetic resonance imaging and ultrasonography fusion biopsy for prostate cancer detection: a cross-sectional study
Authors: Chikazawa Ippei , Kunii Kenshiro , Kondou Tamaki , Miyazawa Katsuhito 
Published: October 2024

Abstract

Background
Comparisons between the transperineal (TP) and the transrectal (TR) approach for prostate biopsies in detecting cancer have been reported; however, there are no reports comparing the cancer detection rates using an anatomical approach. In this study, magnetic resonance imaging and ultrasonography (MRI/US) fusion prostate biopsies were compared between the TP and the TR approaches for detecting cancer at the target sites.
Methods
The MRI/US fusion prostate biopsies were performed between November 2016 and October 2021. There were 251 and 200 patients in the TP and TR groups, respectively. Age, serum prostate specific antigen level, prostate volume, number of biopsies, target site (anterior, posterior, apex, base, middle), cancer detection rate, and the Gleason Grading Group classification were examined.
Results
Significantly higher cancer detection rates were noted for Prostate Imaging Reporting and Data System category 4–5 lesions than for category 3 lesions in both the TP and TR groups (p < 0.001). The cancer detection rates for category 4–5 lesions in the TP and TR groups were 94.4% and 73.3% (p = 0.036), 92.3% and 64.7% (p = 0.017), 69.4% and 93.3% (p = 0.055), and 66.7% and 89.3% (p = 0.010) at the anterior, apex, lateral, and posterior sites, respectively.
Conclusions
The cancer detection rate was significantly different between the TP and TR groups at the anterior, apex, and posterior sites. These differences may be due to the sampling deflection of the needle on the posterior site in the TP group and on the apex and anterior sites in the TR group. These results suggest that urologists should be mindful of the benefits for each patient by considering the advantages with each approach.
Pathways for Intergenerational Transmission of Depression: Differentiating between Positive and Negative Maternal Mental Health
Authors: Tan Ai Peng , Huang Pei , Manahan Aisleen , Lee Marissa , Chan Shi Yu , Ngoh Zhen Ming , Kee Michelle , Phua Desiree , Sathyapalan Anu , Chong Yap Seng , Gluckman Peter , Chen Helen , Fortier Marielle , Daniel Lourdes , Zhou Juan , Law Evelyn , Meaney Michael 
Published: October 2024

Abstract

Our understanding of the pathways by which maternal mental health influences the risk for psychopathology in the offspring remains incomplete despite an obvious importance for prevention. This gap, in part, derives from a largely unique focus on maternal symptoms of psychopathology despite evidence for an influence of positive mental health states on a wide range of neurodevelopmental outcomes in the offspring. In this analysis we used a prospective longitudinal cohort study to compare the influence of positive and negative maternal mental health conditions on offspring language and executive function as potential mediators for the influence of maternal mental health on depressive symptoms in the offspring. Our results show that language and executive function were significantly and specifically correlated to positive and negative maternal mental health, respectively. Both functions were significantly correlated with self-reported depressive symptoms at 9 years of age. A serial mediation model showed that language mediated the relation between positive maternal mental health and childhood depressive symptoms. In contrast, executive function mediated the relation between negative maternal mental health and childhood depressive symptoms. Neuroimaging analysis showed that positive and negative maternal mental health were linked to different offspring functional connectivity profiles and highlight the Orbitofrontal-Somatomotor Network B connectivity as a possible neural pathway for the impact of positive maternal mental health on offspring language ability. These results highlight the different operative pathways that link positive and negative maternal mental health to childhood depressive symptoms and provide potential modifiable targets for early intervention.
A nomogram predicts the risk factors for bleeding connected with biliary stent placement therapy
Authors: He Di , Shen Hechen , Yin Weihua , shu guiming 
Published: October 2024

Abstract

Background: Clinically, the ability to predict intra-and postoperative bleeding during stent placement is limited, particularly in patients with high-risk bleeding factors or coagulation disorders. The aim of this study was to create a nomogram to predict bleeding from stent implantation.
Methods: Medical records were collected on March 25, 2024, for 590 cases.
Logistic regression was used to construct the nomogram, and variable screening was performed through LASSO regression. The area under the curve (AUC) was calculated to determine the discriminative capacity of each model. A calibration curve was used to evaluate the prediction accuracy of the model, and the consistency index (CI) was used to determine the performance of the model. Clinical effectiveness was assessed through the use of decision curve analysis (DCA).
Results：LASSO regression identified four clinical features of patients, which were used to generate a nomogram. The AUC was 0.816 (95% CI, 0.743-0.889) in the training model and 0.804 (95% CI, 0.691-0.916) in the test set model. The proposed nomogram would yield a net gain in forecasting stent insertion bleeding if the threshold likelihood of bleeding fell between 0 and 0.8, as demonstrated by a well-calibrated predictive model and DCA.
Conclusions: Four clinical traits of patients who underwent stent placement were combined to create a nomogram predicting risk of bleeding.
Measuring emotional invalidation in Iranian populations: Persian version of perceived invalidation of emotion scale (P_PIES)
Authors: Rezaei Mehdi , Paripishbar Zahra , khazaei Samaneh 
Published: October 2024

Abstract

The examination of the psychometric properties of the PIES in Eastern cultures has remained unexplored. The current study aims to explore the psychometric features of the PIES in Iranian populations. A total of 2250 participants (clinical sample = 177, student samples = 1762, general population = 311) completed the following questionnaires: Perceived Invalidation of Emotion Scale (PIES), Childhood Trauma Questionnaire-Short form (CTQ-SF), Depression, Anxiety and Stress (DASS-2), and the Difficulties in Emotion Regulation Scale-16 (DERS-16). The psychometric qualities of the PIES were examined using construct, convergent, discriminant, incremental, and predictive validities together with internal consistency and test-retest reliability. The results of exploratory and confirmatory factor analysis revealed that the PIES had a unifactorial structure. Support was found for internal consistency as well as for test-retest reliability. In addition, the PIES scores significantly predicted emotional distress over time and had positive correlations with emotional dysregulation, childhood traumas, anxiety, stress, and depression. The PIES was also found to discriminate the clinical from nonclinical populations. Finally, PIES demonstrated adequate incremental validity. Despite the limitations of the current study and the need for additional research, the findings indicate that the PIES with unifactorial structure is a reliable and valid scale among Iranian populations.
Mouse Tissue imaging by random laser of Plasmonic two dimensional array
Authors: Lateef M. , Aldaim W. A. , Haddawi S. F. , Hamidi S. M. 
Published: October 2024

Abstract

Given the major applications of high resolution, and non-destructive bio-imaging, plasmonic waveguide assisted imaging system based on the random lasing is proposed here by helping micro ring arrays covered with the gold/ graphene layer and Rh6G dye. In order to achieve this objective, we employ a laser writing system to create micro ring arrays and subsequently cover them with a plasmonic gold thin film using a sputtering machine. Additionally, the chemical vapor deposition method is employed to generate the graphene layer. To use this medium as random laser active media, we cover it by Rh6G dye and PVP polymer as the top high index layer to get more localization of light. After theoretically and experimentally evaluating the plasmonic substrate, we use second harmonic generation of Nd: YAG laser as the source, and record the random lasing of the sample under 45 degree via spectrometer. Our results show the samples without PVP layer yield a coherent random laser with about 6 nm and 1.4 nm in the full width at half maximum (FWHM), threshold energy 3.17 mJ and 1.42 mJ for concentrations 10 − 5 and 10 − 4, respectively. While finding the laser threshold and FWHM are decreased by the sample with PVP layer reach from 2.62mJ and 5 nm to 1.95 mJ and 1.2 nm, respectively. This corresponded to the simulation part, in which PVP layer enhanced the field amplitude significantly. Finally, we record the images of mouse tissue by the CCD camera. These findings provided a simple and efficient way for the realization of low-threshold random lasers at low cost.
The Influence of Platelet Indicators on ABO Blood Group-Related Susceptibility to Lung Adenocarcinoma: A Multicenter Retrospective Cohort Study
Authors: Zhang Ting , Xiang Mingfei , Yin Hailin , Dan Jiaqiang , Zu Ruiling , Rao Lubei , zhang Peiying , Wang Yuan , Yang Ran , Zhang Yun , Luo Huaichao 
Published: October 2024

Abstract

Objective
The aim of this study was to investigate the role of platelet indicators in the susceptibility of ABO blood groups to lung adenocarcinoma.
Methods
This was a multicenter retrospective cohort analysis. The study included 528 patients diagnosed with primary lung adenocarcinoma and 528 randomly selected benign patients who were admitted to the Chengdu Fifth People’s Hospital from January 2021 to September 2023. Additionally, it included 1452 patients diagnosed with primary lung adenocarcinoma and 1452 benign patients who were admitted to the Sichuan Cancer Hospital from November 2013 to May 2021. Platelet indicators were studied using an automated blood counter. ABO blood groups were determined by the gel column method using agglutination techniques. Statistical analysis was performed using Chi-square tests, independent-samples T-tests, ANOVA, and logistic regression.
Results
Chi-square analysis showed that there was a difference in ABO blood group composition between the lung adenocarcinoma group and the control group(p < 0.001). Independent-samples T-tests showed that MPV was significantly higher in lung adenocarcinoma than in control group(p = 0.025). The ANOVA of ABO blood groups and platelet indicators in lung adenocarcinoma showed that the average platelet count (PLT) of O group blood was higher than that of B group blood(p = 0.037), while the mean platelet volume (MPV) was significantly lower than that of A group, B group and AB group blood(p = 0.009). After adjusting for gender and age, logistic regression analysis showed that the risk of lung adenocarcinoma in blood groups O and B was higher than that in blood group A (p < 0.05 for each) and blood group AB (p < 0.05 for each), regardless of whether platelet indicators were added. Meanwhile, logistic regression showed that high platelet volume (MPV) was a risk factor for lung adenocarcinoma (p = 0.029).
Conclusion
Our findings suggest that platelet indicators are respectively associated with ABO blood groups and lung adenocarcinoma. However, Platelet Indicators may not influence the ABO blood groups related Susceptibility to Lung Adenocarcinoma.
Rabies-Preventive Health Program for Mothers in Maternal and Child Health Centers
Authors: baraka Samia Ibrahim Mabrouk , Nour Rania Abd Elmohsen Abo El , Abdelzaher M. A. , –Nasr Eman Mahmoud Seif El 
Published: October 2024

Abstract

Background: Rabies spreads to people and animals via saliva, usually through bites, scratches, or direct contact with mucosa (e.g. eyes, mouth, or open wounds). Rabies remains a major public health problem in Egypt, with an estimated 60 people dying annually from the disease.
The aim of this study was to assess the effect of preventive program on mothers' awareness for prevention of rabies.
Study Design: Quasi- experimental research design was utilized in this study.
Setting: This study was conducted at three major Maternal and child centers (Botors, Embaby and Segar) in Tanta City.
Sample: A total sample of 150 mothers who attended the child clinic with children aged 6-12 years.
Tools: three tools were developed by researchers were used for data collection. A Structured interviewing questionnaire for assessment of mothers’ knowledge, attitudes and practices regarding rabies Tool I, Mothers' knowledge regarding rabies questnnaire. This tool consisted of two parts: demographic characteristics of the studied mothers and mothers’ knowledge about rabies. Tool II, Rabies attitudinal Likert scale. Tool III, Mothers reported practice Questionnaire.
Results: from the obtained results, it was found that, a statistically significant correlation was found between mothers' total knowledge scores, attitude and total practice scores, both before and after the implementation of the rabies prevention program.
Conclusion: It was concluded that the rabies- preventive health program had positive impact on mother’s knowledge, attitude and practices regarding rabies.
Recommendations: dissemination of the program to the public through mass media to increase their knowledge; improve attitude and practices regarding rabies and its preventive measures.
The relationship of retinal nerve fiber layer thickness and visual field parameter in eight sectors of primary open-angle glaucoma with high myopia based on spectral-domain OCT
Authors: Ruan Jia-Li , Qiu Chen , Qian Shaohong 
Published: October 2024

Abstract

To assess the structure-function relationship of retinal nerve fiber layer (RNFL) thickness in eight sectors based on spectral-domain optical coherence tomography (OCT) with visual field deviation in primary open-angle glaucoma(POAG) patients with high myopia. 225 eyes of 128 patients all diagnosed with POAG were enrolled and stratified by axial length(AL) into moderate ( 25mm ≤ AL < 25.99mm, n = 70 eyes), high (26mm ≤ AL < 26.99mm, n = 76 eyes) and super-high (27mm ≤ AL < 30mm, n = 79 eyes) myopia POAG groups. Data of RNFL thickness and visual field parameters was separated in eight sectors: superotemporal(ST), superonasal(SN), nasal-up(NU), nasal-low(NL), inferonasal(IN), inferotemporal(IT), temporal-low(TL), temporal-up(TU). The Pearson correlation coefficient analysis showed strong structure-function correlation in ST/IT (R = 0.654 to 0.741, p < 0.001) sectors despite AL elongation from 25mm to 30mm in myopia POAG. Also we found decreasing correlation in TL/TU/IN/SN (R = 0.264 to 0.595, p < 0.01) sectors with AL elongation in myopia POAG, with the changed node occurred in 27mm for IN/SN and in 26mm for TL/TU. Specially in NU/NL, the weak correlation(R = 0.233 to 0.381, p < 0.05) became no correlation(p > 0.05) when AL elongated from 25mm to 27mm and above. These descriptions may be helpful to observe and monitor the progression in POAG with high myopia.
Key Cancer Glycosylation-related Genes Analysis: Regulatory, Therapeutic, and Prognostic Insights
Authors: Wang Yida , Chen Xuanming , Jin Xiangyu , Bao Jinku 
Published: October 2024

Abstract

Background: Glycosylation, a key post-translational modification, involves glycosylation-related genes (GRGs) that are crucial in cancer development. Despite their significance, the roles of GRGs in cancer pathways remain insufficiently understood. This study aims to elucidate the function of GRGs across different cancer types, assessing their potential impact on treatment and prognosis.
Methods: We conducted an extensive analysis of over 9,000 samples spanning 33 cancer types, focusing on genomic alterations, cluster analysis, pathway correlations, tumor immunity, miRNA interactions, and identification of therapeutic agents targeting GRGs.
Results: Our genomic landscape analysis identified significant events such as the amplification of B4GALT1 and POMGNT1, co-mutations of POMGNT1-GALNT3-FUT3, and co-amplifications of POMGNT1-B4GALT2. Cluster analysis based on GRG expression revealed four distinct cancer subtypes. Pathway analysis demonstrated a positive correlation between GRGs and both E2F_TARGET and p53_PATHWAY. Additionally, GRGs were involved in tumor immunity and predicted responses to PD-1 blockade therapy. A network of miRNA-GRG interactions was uncovered, and GRG expression was predictive of patient survival across 21 cancer types. We also identified potential therapeutic agents targeting key GRGs.
Conclusions: This comprehensive analysis of GRGs provides critical insights into their roles in cancer development, prognosis, and therapy, offering a robust foundation for future functional and therapeutic studies in oncology.
Evaluation of S. uric acid in COPD patients
Authors: Hendy Rasha Mohamed , Elsaid Salwa Hassan Mohammed 
Published: October 2024

Abstract

Airway inflammation and imbalance between oxidant/anti-oxidant mechanisms are postulated to play a major role in the pathogenesis of COPD. The work aimed to evaluate serum uric acid among COPD patients
Patients and methods: A retrospective cross-sectional study included 50 COPD patients, who attended Benha University Hospital from March 2022 to November 2023. All patients were subjected to the following; written consent from the patient, full history and clinical examination, ABG, CXR (P-A), pulmonary function tests, measuring serum creatinine and urea, measuring serum uric acid by enzymatic colorimetric assay in a fully automated analyzer.
Results: There was a highly significant negative correlation between patients’ serum uric acid levels and FEV1.There was a highly significant negative correlation between patients’ serum uric acid levels and FEV1̸ FVC
Conclusion: uric acid could be used as a chemical biomarker in predicting COPD severity and staging.
Employing Metagenomic Next-Generation Sequencing for Enhanced Surveillance of Respiratory Viruses in Fever Clinics: A Comparative Analysis in the Context of the COVID-19 Pandemic in a General Hospital
Authors: An Shu , Du Longting , Zhong Pengqiang , Wang Ruizhi , Liu qiangqiang , Li Baisheng , Yang Juhua , Liu Huifang , Xiong Yan , Ding Tao , Du Xiangjun , Chen Peisong 
Published: October 2024

Abstract

Background: Clinical surveillance in hospitals, especially in fever clinic, plays a critical role in detecting and managing emerging infectious diseases, serving as an initial alert system for public health epidemics. However, current clinical surveillance networks lack effective methods for comprehensive viral monitoring.
Aim and Methods: This study aimed to establish a pathogen monitoring method using metagenomic next-generation sequencing (mNGS) for pooled specimens in fever clinics, enhancing the capacity for broad-spectrum viral surveillance. We randomly selected oropharyngeal swab specimens from patients at the Fever Clinic who underwent SARS-CoV-2 nucleic acid testing between June 2022 and June 2023. These specimens were pooled, nucleic acids were extracted following standardized protocols, and pathogens were identified through the mNGS technique.
Results: Our results indicated that mNGS for pooled samples exhibited RNA viral detection efficiency equivalent to that of targeted next-generation sequencing (tNGS) for individual samples. Data obtained from mNGS demonstrated a strong correlation with influenza surveillance data from the Guangzhou CDC. Our surveillance method adeptly tracked the progression of the H3N2 epidemic through June 2023 and pinpointed the spread of COVID-19 by late November 2023. Additionally, our analysis exposed notable variations in the respiratory viral spectrum among patients before and after the COVID-19 outbreak.
Conclusion: Utilizing mNGS for mixed-sample detection in fever clinics proved effective and feasible for pathogen surveillance. The approach enhanced understanding of respiratory virus epidemiology, supporting reduced circulation of non-SARS-CoV-2 respiratory viruses during and after the COVID-19 pandemic. This innovative method strengthens public health surveillance by enabling timely detection and response to respiratory virus outbreaks.