bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of negative COVID-19 experiences on cancer survivors’ health-related quality of life and psychological distress: a moderated mediation model
Authors: Noriega Esquives Blanca S. , Natori Akina , Antoni Michael H. , Otto Amy K. , Prinsloo Sarah , Wagner Richard W. , Gomez Telma I. , Hathaway Cassandra A. , Ulrich Cornelia M. , Peoples Anita R. , Cohen Lorenzo , Penedo Frank J. 
Published: September 2024

IntroductionCancer survivors experienced poorer health-related quality of life (HRQoL) and greater psychological distress during the COVID-19 pandemic than those without cancer. However, the underlying mechanisms that may explain how negative experiences during the pandemic are associated with distress and HRQoL remain unknown. We examined whether psychosocial risk factors (i.e., healthcare disruption, disruption to daily activities and social interaction [DDASI], and financial hardship) mediated the relationship between negative COVID-19-related experiences and cancer survivors’ HRQoL and psychological distress (i.e., depressive symptoms, and anxiety) and whether the mediating effects were moderated by psychosocial protective factors (i.e., stress management ability and social support).MethodsA total of 9,651 cancer survivors completed a questionnaire assessing negative COVID-19-related experiences, psychosocial and practical experiences, and HRQoL. Conditional process analysis was used to evaluate the proposed moderated mediation models.ResultsParticipants had a mean age of 63.8 years (SD = 12.3) and were mostly non-Hispanic White (82.3%). DDASI and financial hardship mediated the relationship between negative COVID-19-related experiences and cancer survivor’s HRQoL and psychological distress. Stress management ability buffered the indirect effect of DDASI on cancer survivors’ HRQoL and psychological distress. Social support buffered the indirect effect of financial hardship on HRQoL and depressive symptoms.ConclusionFinancial resources and social interactions may buffer negative effects of major disruptions such as the COVID-19 pandemic. Future studies should assess the longitudinal impact of these associations.
The interaction between dietary nitrates/nitrites intake and gut microbial metabolites on metabolic syndrome: a cross-sectional study
Authors: Mirzababaei Atieh , Mahmoodi Maryam , Keshtkar Abbasali , Ebrahimi Sara , Pashayee-Khamene Fereshteh , Abaj Faezeh , Radmehr Mina , Khalili Pardis , Mehri Hajmir Mahya , Mirzaei Khadijeh 
Published: September 2024

BackgroundMetabolic syndrome (MetS) prevalence has increased globally.The evidence shows thatdiet and gut microbial metabolites includingtrimethylamine N-oxide (TMAO) and kynurenine (KYN) play an important role in developing MetS. However, there is a lack of evidence on associations between between diet and these metabolites. This study aimed to investigate the interaction between dietary nitrate/nitrite and gut microbial metabolites (TMAO, KYN) on MetS and its components.MethodsThis cross-sectional study included 250 adults aged 20–50 years. Dietary intake was assessed using food frequency questionnaires (FFQ), and serum TMAO and KYN levels were measured. MetS was defined usingthe National Cholesterol Education Program Adult Treatment Panel (NCEP ATP III) criteria.ResultThe ATPIII index revealed an 11% prevalence of metabolic syndrome among the study participants. After adjusting for confounders, significant positive interactions were found: High animal-source nitrate intake and high TMAO levels with elevated triglycerides (TG) (p interaction = 0.07) and abdominal obesity (p interaction = 0.08). High animal-source nitrate intake and high KYN levels with increased TG (p interaction = 0.01) and decreased high-density lipoprotein cholesterol (HDL) (p interaction = 0.01).Individuals with high animal-source nitrite intake and high TMAO levels showed increased risk of hypertriglyceridemia (OR: 1.57, 95%CI: 0.35–2.87, p = 0.05), hypertension (OR: 1.53, 95%CI: 0.33–2.58, p = 0.06), and lower HDL (OR: 1.96, 95%CI: 0.42–2.03, p = 0.04). Similarly, high animal-source nitrite intake with high KYN levels showed lower HDL (OR: 2.44, 95%CI: 1.92–3.89, p = 0.07) and increased risk of hypertension (OR: 2.17,95%CI: 1.69–3.40, p = 0.05). Conversely, Negative interactions were found between high plant-source nitrate/nitrite intake with high KYN and TMAO levels on MetS and some components.ConclusionThere is an interaction between dietary nitrate/nitrite source (animal vs. plant) and gut microbial metabolites (TMAO and KYN) on the risk of of MetS and its components. These findings highlight the importance of considering diet, gut microbiome metabolites, and their interactions in MetS risk assessment.
Learning interventions in the WHO Eastern Mediterranean region: supporting Member States to get prepared for better response to health emergencies in the region
Authors: Elhakim Mohamed , Hammoud Samar Dimachkie , Gmach Sabri , Albadri Jehan , Mahrous Heba , Arifi Fatima , Abdel Latif Nisreen , Moussa Safaa , Anan Huda , Saidouni Asma , Ghazy Ramy Mohamed , Elkholy Amgad , Elsakka Hammam , Samhouri Dalia 
Published: September 2024

BackgroundThe Eastern Mediterranean Region (EMR) faces numerous public health risks caused by biological, chemical, man-made, and natural hazards. This manuscript aimed to assess the multifaceted interventions and strategies used to strengthen the EMR’s preparedness capacities to respond properly to current and upcoming health emergencies.ObjectiveTo address these challenges, it is crucial to implement comprehensive and robust strategic risk assessments and health emergency preparedness frameworks. The World Health Organization (WHO) takes a risk-based approach, emphasizing the significance of all-hazards emergency management and the creation of national health risk profiles using the Strategic Toolkit for Assessing Risk (STAR). Furthermore, the International Health Regulations (IHR) Monitoring and Evaluation Framework (MEF) ensures continuous learning and capacity building among Member States, enhancing their ability to manage health emergencies effectively. Key components include State Party Annual Reporting (SPAR), Joint External Evaluation (JEE), After Action Review (AAR), Intra Action Review (IAR), and Simulation Exercises (SimEx). Moreover, initiatives like One Health, Emergency Care Systems, Safe Hospitals, and Public Health Emergency Operations Centers (PHEOCs) reinforce preparedness and response capacities. Risk communication and community engagement (RCCE) strategies play a pivotal role in disseminating timely information and fostering community resilience. Furthermore, the management of Chemical, Biological, and Radiological (CBRN) incidents remains a priority, necessitating collaboration between the public health and security sectors. This comprehensive approach aims to strengthen health systems, reduce risks, and improve emergency response capabilities throughout the EMR, thereby promoting global health security and resilience.ConclusionThe EMR is addressing public health challenges through frameworks like IHR-MEF, and RCCE. It is strengthening emergency care systems, ensuring safe hospitals, and establishing PHEOCs. Proactive measures to address CBRN events and collaboration are enhancing resilience. The inclusion of the One Health approach underscores the EMR’s holistic strategy to address the health threats at the human-animal-environment interface. This demonstrates the EMR’s commitment to global health security.
McWRKY43 Confers Cold Stress Tolerance in Michelia crassipes via Regulation of Flavonoid Biosynthesis
Authors: Yu Qiuxiu , Liu Caixian , Sun Jiahui , Ding Minghai , Ding Yu , Xu Yun , He Jinsong , Li Qizhen , Jin Xiaoling 
Published: September 2024

WRKY transcription factor (TF) plays a crucial role in plant abiotic stress response, but it is rarely reported in Michelia crassipes. Our studies have found that the transcription factor McWRKY43, a member of the IIc subgroup, is strongly upregulated under cold stress. In this study, we cloned the full length of McWRKY43 to further investigate the function of McWRKY43 in resistance to cold stress and its possible regulatory pathways in M. crassipes. Under cold stress, the seed-germination rate of transgenic tobacco was significantly higher than that of the wild type, and the flavonoid content, antioxidant enzyme activities, and proline content of transgenic tobacco seedlings were significantly increased, which promoted the expression of flavonoid pathway structural genes. In addition, the transient transformation of McWRKY43 in the M. crassipes leaves also found the accumulation of flavonoid content and the transcription level of flavonoid structural genes, especially McLDOX, were significantly increased under cold stress. Yeast one-hybrid (Y1H) assay showed that McWRKY43 could bind to McLDOX promoter, and the transcription expression of McLDOX was promoted by McWRKY43 during cold stress treatment. Overall, our results indicated that McWRKY43 is involved in flavonoid biosynthetic pathway to regulate cold stress tolerance of M. crassipes, providing a basis for molecular mechanism of stress resistance in Michelia.
March 2023-Printed Issue
Authors:   Patient Safety Authority
Published: September 2024

The spring 2023 issue of Patient Safety is available to read and download at no charge. This issue features four articles that came out of the Patient Safety Authority’s first master class in writing quality improvement studies. Workshop facilitator Olivia Lounsbury, Quality and Safety Program coordinator at the Johns Hopkins Children’s Center, guided participants in writing about recent studies that had an impact on patient care so others could learn from and replicate their work. • A community hospital took broad, innovative steps to increase compliance with sepsis treatment best practices (https://patientsafetyj.com/article/74015-improving-sepsis-compliance-with-human-factors-interventions-in-a-community-hospital-emergency-room) to meet state and national benchmarks. • A team introduced a process to properly identify, document, and evaluate patients’ risk of adverse drug reactions (https://patientsafetyj.com/article/74022-adverse-drug-reactions-in-moderate-sedation-process-improvement-during-a-pandemic) during moderate sedation. • Researchers studied methods of collecting urine for lab analysis (https://patientsafetyj.com/article/74060-reduction-of-patient-harm-through-decreasing-urine-culture-contamination-in-an-emergency-department-using-multiple-process-improvement-interventions) to prevent contaminated samples from resulting in incorrect diagnoses or delayed care. • A team introduced a first-of-its-kind virtual consultation hotline for staff with central line concerns (https://patientsafetyj.com/article/74075-preventing-central-line-bloodstream-infections-an-interdisciplinary-virtual-model-for-central-line-rounding-and-consultation) to help identify bloodstream infections rapidly and reduce patient harm. This issue also includes new research articles looking at how healthcare can learn from alarm and alert designs from other industries (https://patientsafetyj.com/article/73905-informing-healthcare-alarm-design-and-use-a-human-factors-cross-industry-perspective), and how to assess equipment, supplies, and devices for patient safety issues (https://patientsafetyj.com/article/73988-assessing-equipment-supplies-and-devices-for-patient-safety-issues); a discussion with Dr. Nirmal Joshi, chair of the Patient Safety Authority, about the past, present, and future of healthcare (https://patientsafetyj.com/article/74081-view-from-the-top-an-interview-with-patient-safety-authority-chair-dr-nirmal-joshi); and stories about the powerful impact event reporting has made on patient care (https://patientsafetyj.com/article/74079-events-that-inspired-change-the-importance-of-sharing-what-happened-to-stop-it-from-happening-again). Patient Safety is fully open access (no fees for authors or readers). We welcome submissions from all over the world. If your manuscript can help advance patient safety, please send it to us for consideration (https://patientsafetyj.com/for-authors), and kindly share our journal articles with anyone who would benefit from them.
DETERMINATION OF OPTIMAL BLOOD PARAMETERS FOR THE BROWN SWISS BREED WHEN IMPROVING KOSTROMA BREED CATTLE
Authors: БАРАНОВА Н.С. , ФУРАЕВА Н.С. , ЗВЕРЕВА Е.А. , КОРОЛЕВ А.А. , ВОРОБЬЕВА С.С. 
Published: September 2024

Определены оптимальные параметры кровности по бурой швицкой породе при совершенствовании скота костромской породы. Средняя кровность коров костромской породы по бурой швицкой породе в племенных хозяйствах Костромской области составила 52,3%. Кровность быков, поставленных на проверку, и накопление семени в АО «Ярославское» по племенной работе колеблются от 16 до 82%. С увеличением кровности по бурой швицкой породе возрастают удой, содержание жира и белка в молоке, но снижаются воспроизводительные качества, сокращается срок хозяйственного использования скота. Отмечены наиболее молочные линии и родственные группы в костромской породе — Хилла 76059 и Курса 3722, белковомолочные — Курса 3722 и Леирда 71151. Коровы линий Курса 3722, Ладка 2537 и родственной группы Хилла 76059 отличаются лучшими воспроизводительными качествами. В АО «Ярославское» по племенной работе содержатся быки 7 генеалогических линий со средней продуктивностью матерей 9901 кг молока, с содержанием в нем 4,19% жира и 3,32% белка, для обеспечения генеалогического разнообразия в породе. Оптимальный возраст коров при 1-м осеменении составил от 14 до 16 мес при живой массе 393—396 кг. У телок, осемененных в более раннем возрасте, отмечены: удой от 7350 до 8351 кг, при высоком содержании в молоке жира (4,07—4,14%) и белка (3,53—3,55%), скорость молокоотдачи 2,14—2,24 кг/мин и самый короткий сервис-период — 138—154 дня.
The article presents material on determining the optimal blood parameters for the Brown Swiss breed when improving Kostroma breed cattle. Installed, it was revealed that the average blood quality of cows of the Kostroma breed compared to the Brown Swiss breed in breeding farms of the Kostroma region was 52,3%. The blood quality of bulls submitted for testing and accumulation of semen at JSC Yaroslavskoye for breeding work ranges from 16% to 82%. With an increase in the blood level of the Brown Swiss breed, milk yield, fat and protein content in milk increase, but reproductive qualities decrease, and the economic life of livestock is reduced. The most dairy lines and related groups in the Kostroma breed are noted — Hilla 76059 and Kursa 3722, milk-protein lines — Kursa 3722 and Leirda 71151. Cows of the lines Kursa 3722, Ladka 2537 and the related group Hilla 76059 are distinguished by the best reproductive qualities. JSC "Yaroslavskoe" for breeding work contains bulls of 7 genealogical lines with an average maternal productivity of 9901 kg of milk, fat content of 4,19%, protein — 3,32% to ensure genealogical diversity in the breed. The optimal age at 1 insemination was from 14 to 16 months with a live weight of 393-396 kg. In heifers inseminated at an earlier age, milk yield ranged from 7350 to 8351 kg of milk with a high fat content of 4,07—4,14% and protein of 3,53-3,55% in milk, milk yield rate of 2,14—2,24 kg/min. and the shortest service period is 138—154 days.
EFFICIENCY OF FEEDING HIGH-YIELDING COWS A PREBIOTIC SUPPLEMENT AT AN AVERAGE FEEDING LEVEL
Authors: ДУБОРЕЗОВ В.М. , КУВШИНОВ В.Н. , ЦИС Е.Ю. 
Published: September 2024

Скармливание голштинизированным черно-пестрым высокопродуктивным коровам при среднем уровне кормления пребиотической кормовой добавки, произведенной на основе микроскопических водорослей хлореллы по инновационной технологии в виде суспензии, в количестве 1 л на голову в сутки способствовало повышению среднесуточного удоя молока натуральной жирности. Разница между показателями в контрольной и опытной группах за весь период исследований составила 2,29 кг, или 9,08%. Использование пребиотической кормовой добавки в составе рациона способствовало увеличению жирномолочной и белковомолочной продуктивности. При равнозначных показателях жирности молока у подопытных животных в начале учетного периода (3,48%), в среднем за 120 дней опыта установлено более высокое значение жира в молоке коров контрольной группы — на 0,14 п.п. по сравнению с животными, получавшими пребиотическую добавку. При этом сумма молочного жира, полученного от коров опытной группы, составила 122,46 кг, что на 7,6% больше, чем у аналогов из контроля. По белковомолочной продуктивности подопытных животных отмечена тенденция, аналогичная жирномолочной продуктивности. За период научно-хозяйственного опыта содержание белка в молоке коров из контрольной группы было выше и в среднем составило 3,62% против 3,48% в опытной группе. Однако у коров, получавших пребиотическую добавку, за счет более высокого удоя выход молочного белка был на 5,26 кг, или 4,86%, больше, чем в контрольной группе.
Feeding Holsteinized black-breed high-yielding cows at an average level of feeding prebiotic feed additive produced on the basis of microscopic algae Chlorella by innovative technology in the form of suspension, in the amount of 1 liter per head per day contributed to an increase in the average daily milk yield of natural fat content. The difference between the indicators in the control and experimental groups for the whole period of research amounted to 2.29 kg or 9.08%. The use of prebiotic feed additive as part of the diet promoted an increase in fat-milk and protein-milk productivity. At equal indicators of milk fatness in experimental animals at the beginning of the accounting period (3,48%), on the average for 120 days of the experiment a higher value of fat in milk of cows of the control group was found — by 0,14 p.p. in comparison with the animals that received prebiotic additive. At the same time, the sum of milk fat obtained from the cows of the experimental group amounted to 122.46 kg, which is 7.6% more than that of their counterparts from the control group. Protein-milk productivity of experimental animals showed a trend similar to fat-milk productivity. During the period of scientific and economic experience the protein content in milk of cows from the control group was higher and averaged 3.62% against 3.48% in the experimental group. However, the cows receiving prebiotic supplement had 5.26 kg or 4.86% more milk protein yield than the control group due to higher milk yield.
PENGARUH TAX AVOIDANCE DAN FIRM SIZE BESERTA VARIABLE LAINNYA TERHADAP FIRM VALUE
Authors: Ryan Nicholas , Suryanto Suryanto 
Published: September 2024

Abstract: This study aims to provide empirical evidence regarding the influence of tax avoidance, profitability, liquidity, leverage, firm size, and dividend policy on firm value. The population in this study consists of companies in the cyclicals and non-cyclicals sectors listed on the IDX from 2020 to 2022. The sample was obtained using purposive sampling method, with 35 companies selected as the sample, resulting in a total of 103 data points after outlier testing. This research uses multiple linear regression model to test hypotheses and to analyse the data. The results of this study indicate that profitability, liquidity, and leverage have an influence on firm value. However, tax avoidance, firm size, and dividend policy do not have an influence on firm value.

Keywords: firm value, tax avoidance, profitability, liquidity, leverage, firm size, dividend policy
Ventana pericárdica y drenaje como tratamiento del hemopericardio en pacientes con trauma penetrante torácico.
Authors: Ortega Jhonatan , Loaiza Paula , Ramos Juan Pablo 
Published: September 2024

Introducción:Si bien la ventana pericárdica (VP) se utiliza como método diagnóstico para el hemopericardio, existe evidencia que puede ser utilizada como tratamiento, en pacientes que presentan estabilidad hemodinámica. El objetivo de este trabajo es describir el tratamiento mediante VP de 6 pacientes con hemopericardio por trauma penetrante ingresados en el hospital Dr. Sótero del Río. Métodos: Se analizaron una serie de 6 pacientes en donde se utilizó la VP como método terapéutico entre el 2022-2023 en el hospital Dr. Sótero del Río. Resultados: De los 6 pacientes analizados 5 se ingresan por arma blanca y 1 por arma de fuego, perdigones. La totalidad de los pacientes son hombres y el tiempo de traslado fue menor a 10 minutos, 4 pacientes presentaron una evaluación enfocada extendida con ecografía en trauma (E-FAST) positivo para hemopericardio y 2 dudoso, 5 se manejaron por VP subxifoidea y 1 por VP transdiafragmática. Existió solo una conversión a toracotomía, 1 paciente requirió laparoscopia exploratoria por presentar una lesión toracoabdominal izquierda y 1 paciente laparotomía exploratoria por trauma hepático con sangrado activo en la misma cirugía. El tiempo de hospitalización máximo fue de 10 días. A la totalidad se le realizó seguimiento mediante ecocardiografía que resultó normal. Conclusión: El tratamiento mediante ventana pericárdica subxifoidea (VPS) del hemopericardio por trauma penetrante es factible. Sin embargo, se debe realizar en un centro altamente protocolizado.
TRAUMA HEPÁTICO: REPORTE DE SERIE DE CASOS DE MANEJO DE LESIÓN HEPÁTICA CON EL USO DE TAPONAMIENTO INTRAPARENQUIMATOSO
Authors: Chaparro Bustamante Sergio Fernando , Araneda González Bárbara Constanza , Fernandez Araya Valentina Paz 
Published: September 2024

Introducción: Las lesiones hepáticas severas se asocian a gran mortalidad debido a hemorragia pre e intraoperatoria o complicaciones postoperatorias como sepsis y shock. Dentro del manejo se ha descrito: packing, maniobra de Pringle, agentes hemostáticos, sutura, finger fracture y parche omental, como técnicas aceptadas, pero, muchas veces no logran proporcionar su objetivo cuando son lesiones severas o centrales.Objetivo: Describir casos clínicos de lesiones traumáticas hepáticas manejadas con taponamiento intraparenquimatoso.Materiales y métodos: Se reportan 5 casos clínicos de lesiones transfixiantes hepáticas manejadas con taponamiento intraparenquimatoso con balón de Sengstaken-Blakemore.Resultado: Todos los casos evolucionaron de manera satisfactoria, con retiro del balón entre el tercer y dieciseisavo día. En nuestra serie sólo un paciente cursó con fístula biliar postoperatoria, que resolvió espontáneamente.Discusión: A pesar de la gran variedad de técnicas descritas, aún no existe un consenso definitivo. El método de tapón intrahepático con balón, ha demostrado ser efectivo en controlar la hemorragia hepática y reducir la mortalidad, por lo que se plantea esta alternativa como viable en cualquier centro para el tratamiento de lesión transfixiante hepática.