bluuebunny/crossref_metadata_2025_split huggingface dataset:
Avaliação das boas práticas de fabricação em uma pizzaria no município de Niterói (RJ)
Authors: Santos Erika Cristina Silva dos , Terence Yasmin Sampaio , Silva Tânia Muzy da 
Published: September 2024

Esse estudo teve como objetivo avaliar a conformidade das boas práticas de fabricação (BPF) em uma pizzaria delivery no município de Niterói (RJ). A pesquisa foi realizada em setembro e outubro de 2022 com aplicação de 2 checklists: um para o setor de produção e outro para o delivery. Os critérios foram definidos pelas pesquisadoras junto com o gestor do estabelecimento, sendo excelente > 90%; bom ≥ 70 - 89%; regular ≥ 50 - 69%; ruim ≥ 20 a 49% e péssimo < 19%. No setor de produção, houve não conformidade em análise estrutural (53%), higienização de equipamentos, móveis e utensílios (57%); controle integrado de vetores e pragas urbanas (75%); abastecimento de água (50%), armazenamento (50%) e 0% para documentação e registro. 100% de conformidade para manejo de resíduos; manipuladores; matérias primas, ingredientes e embalagens; preparação do alimento e responsabilidade. Para o delivery, houve conformidade em 71% para os itens de entrega, 67% da estrutura para funcionários, 75% para o entregador e 60% para o armazenamento. Destaca-se, assim, a importância da implementação das BPF, capacitação da equipe, controle e supervisão em todo o processo, incluindo a entrega.
Analisis Pengelolaan Administrasi Keuangan Dan Pengeluaran Pada Lanud Surya Darma Kalijati
Authors: Rusmanto Gilang , Kholid Nour 
Published: September 2024

Penelitian ini bertujuan untuk menjelaskan pengelolaan administrasi Keuangan pada kantor pekas lanud surya darma . Jenis penelitian yang digunakan dalam penelitian ini adalah menggunakan metode pendekatan kualitatif. Sumber Data yang diolah di ambil dari laporan anggaran Kantor pekas lanud surya darma yang di dapatkan dari laporan tahunan Kantor pekas lanud surya darma . jenis data berupa data kualitatif. Teknik penumpulan data di lakukan dengan cara penumpulan dokumen laporan. yaitu dengan langkah mengumpulkan dan menyaring keterangan-keterangan yang diperoleh secara menyeluruh dan detail, kemudian diuraikan sehingga diperoleh gambaran yang jelas.teknik analisis data berupa deskriftif .berdasarkan penelitian yang di lakukan hasil pengumpulan data pada Kantor pekas lanud suryadarma. .dapat diketahui bahwa pengelolaan administrasi keuangan pada kantor pekas lanud surya darma sudah sesuai dengan Undang-undang Republik Indonesia.
Enhancing Broccoli (Brassica oleracea L. var. italica Plenk) Yield with Efficient Water Use: A Marginal Analysis of Irrigation and Water Saving Techniques
Authors: Jaybhaye Pralhad , Mukherjee Asis 
Published: September 2024

Climate change impacts are more evident in agriculture sector at micro level in general, and technological interventions (e.g. cropping patterns, crop diversification, soil health management, rainwater harvesting, use of modern irrigation system with precise irrigation quantity etc.) are some of the interventions which can play a significant role in enhancing the current capacity of farmers to cope with climate change. The experiment was conducted at the “C” Block Research Farm at Kalyani of the BCKV, Mohanpur, India during winter season (November–January) of the year 2016–2017and 2017–2018; to study the relationship between ET and fruit yield, water use efficiency (WUE), net evapotranspiration efficiency (ETWUE) and irrigation use efficiency (IWUE), to develop the MWUE and EWP functions, to estimate the critical level of ET for obtaining maximum WUE and maximum yield, to screen out most suitable and efficient water saving techniques on the basis of the above production function. The experimental design was a split plot with four irrigation regimes (I1.0, I0.75, I0.50 and I0.25) as main treatment and five water saving techniques {no water saving techniques (MC – controlled); MH - hydrogel; MK - potassium nitrate (KNO3) ; MBP - black polyethylene mulch and MPS - paddy straw mulch as sub treatment. Net head fresh yield under I1.0 was 15.17 Mg ha-1; which reduced by 6, 19 and 35 % respectively under I0.75; I0.50 and I0.25. Different water saving techniques increased yield by 5-34 % over non-water saving techniques condition. Irrespective of water saving techniques, WUE, ETWUE and IWUE were found to be the highest (11 kg m−3, 15 kg m−3 and 17 kg m−3 respectively) under moderately wet (I0.75) soil environment. Among different water saving techniques, MBP recorded the highest WUE (13 kg m−3), ETWUE (19 kg m−3) and IWUE (18 kg m−3) values. The marginal analysis showed difference in critical values of SET against maximum WUE and maximum yield was narrowed down under bio or polyethylene mulches and hydrogel compared to the bare situation.
Assessing the Impact of Sulfur, Magnesium, and Acephate on Mustard Crop Performance
Authors: Patel Krishna Kumar , Kumar Anil , Kumar Ravindra , Sharma Sanjeev , Kumar Kaushal , Kumar Sajneev , Baheliya Ajay Kumar , Kumar Pardeep , Yadav Dev Narayan 
Published: September 2024

Field experiments were conducted to studies the interaction effect of sulphur, magnesium and acephate on growth parameters, yield components and yield of mustard during rabi season of 2022-23 and 2023-24 at students instructional farm, Chandra Shekhar Azad University of Agriculture & Technology, Kanpur under Central Plain Zone of Uttar Pradesh. The experiment consist of 18 treatments combinations in factorial randomized block design with three replications consisted of three levels of sulphur (0, 20 and 40 kg ha-1), three magnesium levels (0, 10 and 20 kg ha-1) and two pesticide levels (with acephate and without acephate). The results demonstrated significant improvements in growth parameters with the combined treatments, notably increasing plant height to 183.25 cm at 60 days after sowing. While plant population remained constant at 13.44 plants per square meter, dry matter accumulation rose from 27.13 g to 28.22 g per plant, and branching increased from 12.59 to 13.14 branches per plant. The S and Mg treatments synergistically enhanced leaf development, with the highest leaf counts observed in the S x Mg treatment. Yield attributes, including the number of siliques per plant and seeds per silique, were significantly improved, particularly with the S x Mg and S x Mg x I interactions. Seed production and stover yield were also notably increased, emphasizing the importance of integrated nutrient and pest management for optimizing mustard production.
Unravelling Tamoxifen’s Neuroprotective Effects against Manganese-Induced Neurodegeneration, Cognitive Impairment and Hippocampal Damage Via the Nrf-2 Pathway in Adult Male Wistar Rats
Authors: Owoyemi Ewaoluwa P. , Ogunlade Babatunde , Olawale Mojisola A. , Boboye Ayodeji S. 
Published: September 2024

Aims: Neurodegenerative diseases pose a serious threat to public health. Manganese (Mn) is a metal necessary for biological systems; however, it can become hazardous at high concentrations, causing neurological damage. This study explores tamoxifen's potential to protect against Mn-induced neurotoxicity in adult male Wistar rats.
Methodology: Forty (40) adult male Wistar Rats weighing between 170g-220g were used and divided into four groups (A-D) (n=10). Manganese (Mn) and Tamoxifen (TMX) dosages were prepared and administered daily for 45 days through oral gavage. Group A received normal saline as a placebo; Group B received 200 mg/kgbwt of Mn only; Group C received 100 mg/kgbwt of TMX and 200 mg/kgbwt of Mn; Group D received 100 mg/kgbwt of TMX only. At the end of the experiment, behavioral tests were carried out, and animals were sacrificed; the brain was then excised, cleaned, and washed with saline for analysis.
Results: After the 45 days of treatment the Mn-only group exhibited clear signs of neurobehavioral toxicity. On the other hand, the TMX-treated rats exhibited significantly improved exploratory behavior and locomotor activity indicating its effect in reverting Mn neurotoxicity. The histological assessments further revealed that TMX preserved hippocampal morphology, reducing glial cell distortion and vacuolation caused by Mn exposure, while the immunohistochemical analysis showed activated Nrf-2 expression in TMX-treated groups.
Conclusion: These results suggest that TMX has significant neuroprotective effects and could be a potential therapeutic agent for neurodegenerative diseases.
Maximizing the Plasmid Yield in Laboratory-scale Maxiprep Preparations through a Modified Alkaline Lysis Approach
Authors: Jaisree S. , Shoba K. , Ramesh A. , Vijayarani K. , Vairamuthu S. 
Published: September 2024

Plasmid purification is an important step in molecular biology and good quality / quantity of plasmids are essential for cloning, production of therapeutic plasmid. Commercial kits for plasmid purification are costlier and the traditional methods are suitable for lesser culture volume. Hence, the study was aimed to enhance the yield of therapeutic grade plasmid in maxiprep preparation by modifying culturing conditions and the traditional alkaline lysis method. To increase the yield of bacterial cell mass carrying the plasmid of interest, LB broth supplemented with 1.9% yeast extract (LBY) was used. The dry pellet yield (g/ 250 ml of culture volume) of DH5α cells containing recombinant plasmid (pVAX1 -ILTV-gB) in LB broth and LBY broth after 18 hours of overnight culture were 1.142 ± 0.016 and 1.535 ± 0.016, respectively. Further, the traditional alkaline lysis method was improved by using calcium chloride, Sodium chloride and PEG6000 (40%) which boosted the yield of plasmid with increasing amount of supercoiled plasmid. The mean yield of plasmid purified from 250 ml of culture volume using the commercial kit and the modified method was 566 µg and 3530 µg, respectively. The modified alkaline lysis method yielded five times higher yield compared to purification by kit. The plasmid purified using the modified method was pure, cost-effective, and ideal for cloning and transfection. This modified method of purification enhanced the yield of supercoiled plasmid which is essential for therapeutic purpose.
Shear localization in a mature mylonitic rock analog during fast slip
Authors: Takahashi M. , van den Ende M. P. A. , Niemeijer A. R. , Spiers C. J. 
Published: January 2017

AbstractHighly localized slip zones developed within ductile shear zones, such as pseudotachylyte bands occurring within mylonitic fabric rocks, are frequently interpreted as evidence for earthquake nucleation and/or propagation within the ductile regime. To understand brittle/frictional shear localization processes in ductile shear zones and to relate these to earthquake nucleation and propagation, we performed tests with large changes in velocity on a brine‐saturated, 80:20 (wt %) mixture of halite and muscovite gouge after forming a mature mylonitic structure through frictional‐viscous flow. The direct effect a on shear strength that occurs in response to an instantaneous upward velocity‐step is an important parameter in determining the nature of seismic rupture nucleation and propagation. We obtained reproducible results regarding low‐velocity mechanical behavior compared with previous work, but also obtained new insights into effects of sudden increases in slip velocity on localization and strength evolution, at velocities above a critical velocity Vc (∼20 μm/s). We found that once a ductile, mylonitic structure has developed in a shear zone, subsequent cataclastic deformation is consistently localized in a narrow zone. This switch to localized deformation is controlled by the imposed velocity and becomes most apparent at velocities above Vc. In addition, the direct effect drops rapidly when the velocity exceeds Vc. This implies that slip can accelerate toward seismic velocities almost instantly and without much loss of fracture energy, once Vc is exceeded. Obtaining a measure for Vc in natural faults is therefore of key importance for understanding earthquake nucleation and propagation in the brittle‐ductile transitional regime.
Cloud‐edge mixing: Direct numerical simulation and observations in Indian Monsoon clouds
Authors: Kumar Bipin , Bera Sudarsan , Prabha Thara V. , Grabowski Wojceich W. 
Published: January 2017

AbstractA direct numerical simulation (DNS) with the decaying turbulence setup has been carried out to study cloud‐edge mixing and its impact on the droplet size distribution (DSD) applying thermodynamic conditions observed in monsoon convective clouds over Indian subcontinent during the Cloud Aerosol Interaction and Precipitation Enhancement EXperiment (CAIPEEX). Evaporation at the cloud‐edges initiates mixing at small scale and gradually introduces larger‐scale fluctuations of the temperature, moisture, and vertical velocity due to droplet evaporation. Our focus is on early evolution of simulated fields that show intriguing similarities to the CAIPEEX cloud observations. A strong dilution at the cloud edge, accompanied by significant spatial variations of the droplet concentration, mean radius, and spectral width, are found in both the DNS and in observations. In DNS, fluctuations of the mean radius and spectral width come from the impact of small‐scale turbulence on the motion and evaporation of inertial droplets. These fluctuations decrease with the increase of the volume over which DNS data are averaged, as one might expect. In cloud observations, these fluctuations also come from other processes, such as entrainment/mixing below the observation level, secondary CCN activation, or variations of CCN activation at the cloud base. Despite large differences in the spatial and temporal scales, the mixing diagram often used in entrainment/mixing studies with aircraft data is remarkably similar for both DNS and cloud observations. We argue that the similarity questions applicability of heuristic ideas based on mixing between two air parcels (that the mixing diagram is designed to properly represent) to the evolution of microphysical properties during turbulent mixing between a cloud and its environment.
Biophysical consequences of photosynthetic temperature acclimation for climate
Authors: Smith Nicholas G. , Lombardozzi Danica , Tawfik Ahmed , Bonan Gordon , Dukes Jeffrey S. 
Published: January 2017

AbstractPhotosynthetic temperature acclimation is a commonly observed process that is increasingly being incorporated into Earth System Models (ESMs). While short‐term acclimation has been shown to increase carbon storage in the future, it is uncertain whether acclimation will directly influence simulated future climate through biophysical mechanisms. Here, we used coupled atmosphere‐biosphere simulations using the Community Earth System Model (CESM) to assess how acclimation‐induced changes in photosynthesis influence global climate under present‐day and future (RCP 8.5) conditions. We ran four 30 year simulations that differed only in sea surface temperatures and atmospheric CO2 (present or future) and whether a mechanism for photosynthetic temperature acclimation was included (yes or no). Acclimation increased future photosynthesis and, consequently, the proportion of energy returned to the atmosphere as latent heat, resulting in reduced surface air temperatures in areas and seasons where acclimation caused the biggest increase in photosynthesis. However, this was partially offset by temperature increases elsewhere, resulting in a small, but significant, global cooling of 0.05°C in the future, similar to that expected from acclimation‐induced increases in future land carbon storage found in previous studies. In the present‐day simulations, the photosynthetic response was not as strong and cooling in highly vegetated regions was less than warming elsewhere, leading to a net global increase in temperatures of 0.04°C. Precipitation responses were variable and rates did not change globally in either time period. These results, combined with carbon‐cycle effects, suggest that models without acclimation may be overestimating positive feedbacks between climate and the land surface in the future.
Activation of the B−F Bond by Diphenylcarbene: A Reversible 1,2‐Fluorine Migration between Boron and Carbon
Authors: Costa Paolo , Mieres‐Perez Joel , Özkan Nesli , Sander Wolfram 
Published: January 2017

AbstractExperiments in low‐temperature matrices reveal that triplet diphenylcarbene inserts into the very strong B−F bond of BF3 in a two‐step reaction. The first step is the formation of a strongly bound Lewis acid–base complex between the singlet state of diphenylcarbene and BF3. This step involves an inversion of the spin state of the carbene from triplet to singlet. The second step requires visible‐light photochemical activation to induce a 1,2‐F migration from boron to the adjacent carbon atom under formation of the formal insertion product of the carbene center into BF3. The 1,2‐F migration is reversible under short‐wavelength UV irradiation, thus leading back to the Lewis acid–base adduct.
Flexible all‐aromatic polyesterimide films with high glass transition temperatures
Authors: Guan Qingbao , Norder Ben , Dingemans Theo J. 
Published: January 2017

ABSTRACTA series all‐aromatic poly(esterimide)s with different molar ratios of N‐(3′‐hydroxyphenyl)‐trimellitimide (IM) and 4‐hydroxybenzoic acid (HBA) (IM/HBA = 0.3/0.7 and 0.7/0.3) was prepared with the aim to design flexible high Tg films. Melt‐pressed films, either from high molecular weight polymer or cured phenylethynyl precursor oligomers, exhibit Tgs in the range of 200 °C to 242 °C and are brittle. After a thermal stretching procedure, the films became remarkably flexible and very easy to handle. In addition, the thermally stretched 3‐IM/7‐HBA and 7‐IM/3‐HBA films show tensile strengths of 108 MPa and 169 MPa, respectively. Thermal treatment increased the Tg of 3‐IM/7‐HBA from 205 °C to 248 °C, whereas the Tg of 7‐IM/3‐HBA increased from 230 °C to 260 °C. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 133, 44774.
Stimulus‐Responsive Short Peptide Nanogels for Controlled Intracellular Drug Release and for Overcoming Tumor Resistance
Authors: Lyu Linna , Liu Fang , Wang Xiaoyong , Hu Ming , Mu Jing , Cheong Haolun , Liu Gang , Xing Bengang 
Published: January 2017

AbstractMultidrug resistance (MDR) poses a major burden to cancer treatment. As one important factor contributing to MDR, overexpression of P‐glycoprotein (P‐gp) results in a reduced intracellular drug accumulation. Hence, the ability to effectively block the efflux protein and to accumulate the therapeutics in cancer cells is of great significance in clinical practice. In this work, we successfully developed a smart stimulus‐responsive short peptide‐assembled system, termed as PD/VER nanogels, which synergistically combined the acid‐activatable antitumor prodrug doxorubicin (Dox) with the P‐gp inhibitor verapamil (VER) for reversing MDR. Systematic studies demonstrated that such an inhibitor‐encapsulated nanogel could effectively enhance the accumulation of Dox in resistant cancer cells, thereby revealing significantly higher antitumor activity compared to free Dox molecules. This work showed that the assembly of bioactive agents with a synergistic effect into nano‐drugs could provide a useful strategy to overcome cancer drug resistance.
Synthesis and luminescence properties of CaSnO3:Bi3+ blue phosphor and the emission improvement by Li+ ion
Authors: Cao Renping , Zhang Jinlong , Wang Wudi , Hu Qianglin , Li Wensheng , Ruan Wen , Ao Hui 
Published: January 2017

AbstractCaSnO3:Bi3+ blue‐emitting phosphor was synthesized using a high‐temperature solid‐state reaction method in air. The crystal structures and luminescence properties were investigated. A broad emission band peaking at ~448 nm upon excitation at 262 and 308 nm was observed in the range 330–680 nm at room temperature due to 3P1 → 1S0 transition of the Bi3+ ion. The chromaticity coordinate was (0.1786, 0.1665). The optimal Bi3+ ion concentration was ~0.6 mol% in CaSnO3:Bi3+ phosphor. The emission spectrum of CaSnO3:Bi3+ phosphor showed a blue‐shift with increasing temperature from 50 to 300 K due to the influence of temperature on the electron transition of the Bi3+ ion. The emission intensity of CaSnO3:Bi3+ phosphor may be increased ~1.45 times by co‐doping Li+ ions as a charge compensator and fluxing agent. The luminescence mechanism is explained by a configurational coordinate diagram of Bi3+ ion in CaSnO3:Bi3+ phosphor.
Systemic inflammatory markers and outcome in patients with locally advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction
Authors: Jagadesham V P , Lagarde S M , Immanuel A , Griffin S M 
Published: January 2017

Abstract

Background
Raised levels of systemic inflammatory markers are associated with poor survival in patients with cancer. The aim of this study was to assess the prognostic value of markers of systemic inflammation in patients with adenocarcinoma of the oesophagus or gastro-oesophageal junction.

Methods
Data from a consecutive series of patients undergoing transthoracic oesophagectomy following neoadjuvant therapy at a single centre were analysed. Fibrinogen, albumin, C-reactive protein, leucocyte differential and platelet counts were measured before surgery. The upper quartile (75th percentile) was used as a cut-off for dichotomization. Multivariable regression analysis was performed to identify independent prognostic factors.

Results
A series of 199 patients underwent transthoracic oesophagectomy following neoadjuvant therapy. Univariable analysis indicated that reduced median survival was associated with a raised platelet : lymphocyte ratio (158 or above; 25.6 versus 44·4 months for patients with a normal ratio, P = 0·038) and increased fibrinogen levels (4·9 g/l or above; 22·8 versus 59·9 months for those with a normal level, P = 0·005). On multivariable analysis a combination of one or more markers of systemic inflammation was associated with poorer overall survival (hazard ratio 2·12, 95 per cent c.i. 1·20 to 3·74; P = 0·010).

Conclusion
Preoperative markers of systemic inflammation predict poor outcome in patients undergoing curative treatment for locally advanced oesophageal and gastro-oesophageal adenocarcinoma.
Moving to the Next Strategy Stage: Examining Firms' Awareness, Motivation and Capability Drivers in Environmental Alliances
Authors: Stadtler Lea , Lin Haiying 
Published: January 2017

AbstractComplementing extant studies on the antecedents of firms' environmental strategy, this article focuses on the trajectories of corporate engagement in proactive environmental alliances. Specifically, we build an awareness–motivation–capability framework and analyze factors that drive the move beyond incremental pollution prevention and facilitate firms' engagement in transformative, sustainable development strategies in their alliances. Based on 212 environmental alliance‐related observations, our test results indicate limited explanatory power of regulatory pressures, but highlight the role of firms' environmental networks to sharpen their awareness to engage in transformative alliances. Further, we elaborate on the nuances and boundary conditions of firms' risk‐taking propensity, industry concentration, financial capacity and especially prior sector‐spanning experiences as motivation and capability drivers. These insights contribute to the discourse on firms' environmental strategy and alliance formation by depicting how and to what extent environment‐specific and more general firm attributes predispose them to engage in transformative rather than incremental environmental projects. Copyright © 2017 John Wiley & Sons, Ltd and ERP Environment