bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broadly neutralizing antiviral responses induced by a single-molecule HPV vaccine based on thermostable thioredoxin-L2 multiepitope nanoparticles
Authors: Spagnoli Gloria , Pouyanfard Somayeh , Cavazzini Davide , Canali Elena , Maggi Stefano , Tommasino Massimo , Bolchi Angelo , Müller Martin , Ottonello Simone 
Published: December 2017

AbstractVaccines targeting the human papillomavirus (HPV) minor capsid protein L2 are emerging as chemico-physically robust and broadly protective alternatives to the current HPV (L1-VLP) vaccines. We have previously developed a trivalent L2 vaccine prototype exploiting Pyrococcus furiosus thioredoxin (PfTrx) as a thermostable scaffold for the separate presentation of three distinct HPV L2(20–38) epitopes. With the aim of achieving a highly immunogenic, yet simpler and more GMP-production affordable formulation, we report here on a novel thermostable nanoparticle vaccine relying on genetic fusion of PfTrx-L2 with the heptamerizing coiled-coil polypeptide OVX313. A prototype HPV16 monoepitope version of this nanoparticle vaccine (PfTrx-L2-OVX313; median radius: 8.6 ± 1.0 nm) proved to be approximately 10-fold more immunogenic and with a strikingly enhanced cross-neutralization capacity compared to its monomeric counterpart. Vaccine-induced (cross-)neutralizing responses were further potentiated in a multiepitope derivative displaying eight different L2(20–38) epitopes, which elicited neutralizing antibodies against 10 different HPVs including three viral types not represented in the vaccine. Considering the prospective safety of the PfTrx scaffold and of the OVX313 heptamerization module, PfTrx-OVX313 nanoparticles lend themselves as robust L2-based immunogens with a high translational potential as a 3rd generation HPV vaccine, but also as a novel and extremely versatile peptide-antigen presentation platform.
Econazole nitrate inhibits PI3K activity and promotes apoptosis in lung cancer cells
Authors: Dong Chao , Yang Runxiang , Li Hongjian , Ke Kunbin , Luo Chunxiang , Yang Fang , Shi Xi-Nan , Zhu Ying , Liu Xu , Wong Man-Hon , Lin Guimiao , Wang Xiaomei , Leung Kwong-Sak , Kung Hsiang-Fu , Chen Ceshi , Lin Marie Chia-mi 
Published: December 2017

AbstractThe phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway plays a pivotal role in many cellular processes, including the proliferation, survival and differentiation of lung cancer cells. Thus, PI3K is a promising therapeutic target for lung cancer treatment. In this study, we applied free and open-source protein-ligand docking software, screened 3167 FDA-approved small molecules, and identified putative PI3Kα inhibitors. Among them, econazole nitrate, an antifungal agent, exhibited the highest activity in decreasing cell viability in pathological types of NSCLC cell lines, including H661 (large cell lung cancer) and A549 (adenocarcinoma). Econazole decreased the protein levels of p-AKT and Bcl-2, but had no effect on the phosphorylation level of ERK. It inhibited cell growth and promote apoptosis in a dose-dependent manner. Furthermore, the combination of econazole and cisplatin exhibited additive and synergistic effects in the H661 and A549 lung cancer cell lines, respectively. Finally, we demonstrated that econazole significantly suppressed A549 tumor growth in nude mice. Our findings suggest that econazole is a new PI3K inhibitor and a potential drug that can be used in lung cancer treatment alone or in combination with cisplatin.
Modeling and prediction of copper removal from aqueous solutions by nZVI/rGO magnetic nanocomposites using ANN-GA and ANN-PSO
Authors: Fan Mingyi , Hu Jiwei , Cao Rensheng , Xiong Kangning , Wei Xionghui 
Published: December 2017

AbstractReduced graphene oxide-supported nanoscale zero-valent iron (nZVI/rGO) magnetic nanocomposites were prepared and then applied in the Cu(II) removal from aqueous solutions. Scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and superconduction quantum interference device magnetometer were performed to characterize the nZVI/rGO nanocomposites. In order to reduce the number of experiments and the economic cost, response surface methodology (RSM) combined with artificial intelligence (AI) techniques, such as artificial neural network (ANN), genetic algorithm (GA) and particle swarm optimization (PSO), has been utilized as a major tool that can model and optimize the removal processes, because a tremendous advance has recently been made on AI that may result in extensive applications. Based on RSM, ANN-GA and ANN-PSO were employed to model the Cu(II) removal process and optimize the operating parameters, e.g., operating temperature, initial pH, initial concentration and contact time. The ANN-PSO model was proven to be an effective tool for modeling and optimizing the Cu(II) removal with a low absolute error and a high removal efficiency. Furthermore, the isotherm, kinetic, thermodynamic studies and the XPS analysis were performed to explore the mechanisms of Cu(II) removal process.
A gradient relationship between low birth weight and IQ: A meta-analysis
Authors: Gu Huaiting , Wang Lixia , Liu Lingfei , Luo Xiu , Wang Jia , Hou Fang , Nkomola Pauline Denis , Li Jing , Liu Genyi , Meng Heng , Zhang Jiajia , Song Ranran 
Published: December 2017

AbstractMultiple studies have reported that individuals with low birth weights (LBW, <2500 g) have a lower intelligence quotient (IQ) than those with normal birth weights (NBW, ≥2500 g). Based on 57 eligible individual studies including 12,137 participants, we performed a meta-analysis to estimate the association between low birth weight and individuals’ IQ scores (IQs). The pooled weight mean difference (WMD) in IQs between NBW and LBW individuals was 10 (95% CI 9.26–11.68). The WMD was stable regardless of age. No publication bias was detected. The mean IQs of the extremely low birth weight (ELBW, <1000 g), very low birth weight (VLBW, 1000–1499 g), moderately low birth weight (MLBW, 1500–2499 g) and NBW individuals were 91, 94, 99 and 104, respectively. Additionally, the WMD in IQs with NBW were 14, 10 and 7 for ELBW, VLBW, and MLBW individuals, respectively. Two studies permitted estimates of the influence of social determinants of health to the discrepancy in IQs, which was 13%. Since IQ is inherited and influenced by environmental factors, parental IQs and other factors contribute to residual confounding of the results. As the conclusion was based on population studies, it may not be applicable to a single individual.
Human Sexual Cycles are Driven by Culture and Match Collective Moods
Authors: Wood Ian B. , Varela Pedro L. , Bollen Johan , Rocha Luis M. , Gonçalves-Sá Joana 
Published: December 2017

AbstractHuman reproduction does not happen uniformly throughout the year and what drives human sexual cycles is a long-standing question. The literature is mixed with respect to whether biological or cultural factors best explain these cycles. The biological hypothesis proposes that human reproductive cycles are an adaptation to the seasonal (hemisphere-dependent) cycles, while the cultural hypothesis proposes that conception dates vary mostly due to cultural factors, such as holidays. However, for many countries, common records used to investigate these hypotheses are incomplete or unavailable, biasing existing analysis towards Northern Hemisphere Christian countries. Here we show that interest in sex peaks sharply online during major cultural and religious celebrations, regardless of hemisphere location. This online interest, when shifted by nine months, corresponds to documented human births, even after adjusting for numerous factors such as language and amount of free time due to holidays. We further show that mood, measured independently on Twitter, contains distinct collective emotions associated with those cultural celebrations. Our results provide converging evidence that the cyclic sexual and reproductive behavior of human populations is mostly driven by culture and that this interest in sex is associated with specific emotions, characteristic of major cultural and religious celebrations.
Influence of body mass index on incidence and prognosis of acute myeloid leukemia and acute promyelocytic leukemia: A meta-analysis
Authors: Li Shufen , Chen Li , Jin Wen , Ma Xuefei , Ma Yunlin , Dong Fangyi , Zhu Hongming , Li Junmin , Wang Kankan 
Published: December 2017

AbstractPrevious studies have demonstrated an association between high body mass index (BMI) and acute myeloid leukemias (AML), particularly acute promyelocytic leukemia (APL). However, the effect of obesity and overweight on the incidence of AML is not supported by all studies, and the relationship between obesity and prognosis of AML and APL has not been established. Thus, we conducted a meta-analysis to determine the role of BMI on the risk and clinical outcome of AML, including APL. Twenty-six eligible studies enrolling 12,971 AML (including 866 APL) patients were retrieved and analyzed. Overweight and obesity was associated with an increased incidence of AML (relative risk [RR], 1.23; 95% confidence interval [CI], 1.12–1.35; P < 0.001). High BMI did not significantly affect overall survival (OS) (hazard ratio [HR], 0.97; 95% CI, 0.92–1.03; P = 0.323) or disease-free survival (HR, 0.98; 95% CI, 0.88–1.10; P = 0.755) in patients with non-APL AML. By contrast, APL patients with high BMI had shorter OS (HR, 1.77; 95% CI, 1.26–2.48; P = 0.001) and a higher risk of differentiation syndrome (HR, 1.53; 95% CI, 1.03–2.27, P = 0.04). Overall, our findings suggest that patients with overweight or obesity have a higher incidence of AML, and high BMI is a predictor of adverse clinical outcomes in APL.
Water quality assessment based on the water quality index method in Lake Poyang: The largest freshwater lake in China
Authors: Wu Zhaoshi , Zhang Dawen , Cai Yongjiu , Wang Xiaolong , Zhang Lu , Chen Yuwei 
Published: December 2017

AbstractTwenty-four samplings were conducted every 3 months at 15 sites from January 2009 to October 2014 in Lake Poyang, and 20 parameters were analyzed and classified into three groups (toxic metals, easily treated parameters, and others). The assessment results based on water quality index (WQI) showed that the water quality in Lake Poyang was generally “moderate”, according to the classification of the surface water quality standard (GB3838-2002) in China, but a deteriorating trend was observed at the interannual scale. Seasonally, the water quality was best in summer and worst in winter. Easily treated parameters generally determined the WQI value in the assessment, especially total nitrogen (TN) and total phosphorus (TP), while toxic metals and other parameters in Lake Poyang were generally at low and safe levels for drinking water. Water level (WL) has a net positive effect on water quality in Lake Poyang through dilution of environmental parameters, which in practice means TN. Consequently, local management agencies should pay more attention to nutrient concentrations during the monitoring schedule, as well as during the low-water periods which manifest a relatively bad water quality state, especially with the prevailing low WL observed recently in Lake Poyang.
The effect of istradefylline for Parkinson’s disease: A meta-analysis
Authors: Sako Wataru , Murakami Nagahisa , Motohama Keisuke , Izumi Yuishin , Kaji Ryuji 
Published: December 2017

AbstractAdenosine A2A receptor antagonists are an alternative treatment strategy for Parkinson’s disease. Several randomized placebo controlled studies have tested the effect of A2A receptor antagonist istradefylline, and more robust evidence has been acquired. This meta-analysis aimed to provide evidence for its efficacy and safety on patients with Parkinson’s disease. After a systematic literature search, we calculated the pooled standardized mean difference and risk ratio for continuous and dichotomous variables, respectively. Further, sensitivity analyses were performed to confirm the effect estimated by meta-analyses. Publication bias was assessed by funnel plot and deviation of intercept. Six studies satisfied our inclusion criteria. Istradefylline (40 mg/day) decreased off time and improved motor symptoms of Parkinson’s disease in homogeneous studies. Istradefylline at 20 mg/day decreased off time and improved motor symptoms, but heterogeneity was found in the analysis of the former among studies. There was a significant effect of istradefylline on dyskinesia in homogeneous studies. Publication bias, however, was observed in the comparison of dyskinesia. Other adverse events showed no significant difference. The present meta-analysis suggests that istradefylline at 40 mg/day could alleviate off time and motor symptoms derived from Parkinson’s disease. Dyskinesia might be worsened, but publication bias prevents this from being clear.
Curved surface effect and manipulation of electronic states in nanosilicon
Authors: Huang Zhong-Mei , Huang Wei-Qi , Wu Xue-Ke , Liu Shi-Rong , Qin Cao-Jian 
Published: December 2017

AbstractIt is interesting in low-dimensional nanostructures of silicon that the two quantum effects play different roles in nanosilicon emission, in which the quantum confinement (QC) effect opens band gap and makes emission shift into shorter wavelengths (blue-shift) as the size of the nanocrystals is reduced; however the breaking symmetry originating from impurities on nanosilicon produces the localized electronic states in band gap and makes emission shift into longer wavelengths (red-shift). The results of experiment and calculation demonstrated that the energy levels of nanosilicon can be manipulated through these quantum effects, where the curved surface (CS) effect of impurity atoms bonding on nanosilicon is important in breaking symmetry of nanosilicon system. Here, the CS effect plays an important role on impuritied nanosilicon in smaller scale with larger surface curvature, in which a few characteristic parameters have been found to describe the breaking symmetry of nanosilicon system, such as bonding angle and projecting length of bonds on curved surface. More interesting, the coupling ways between the QC effect and the CS effect determinate the levels position of localized states in band gap and manipulate emission wavelength, where a few new phenomena were explored.
Bennet's doubler working as a power booster for triboelectric nano‐generators
Authors: Ghaffarinejad A. , Lu Y. , Hinchet R. , Galayko D. , Hasani J.Y. , Kim S.W. , Basset P. 
Published: December 2017

In this Letter, the authors introduce for the first time how a Bennet's doubler conditioning circuit will boost the extracted energy from an electrostatic kinetic energy harvester based on triboelectricity. With zero initial bias on all capacitors, after 1000 charging cycles, the harvested power is amplified by more than 2 orders of magnitude by the Bennet's doubler in comparison to a half‐wave diode bridge. The harvested energy derived from a 3 × 3 cm2 device made of polymer PFA and aluminium is at least 4.6 μJ per tap with the Bennet's doubler conditioning circuit, and only 30 nJ per tap with the half‐wave bridge.
Low-grade Endometrial Stromal Sarcoma with Unusual Metastasis to the Skull
Authors: Araújo Júnior Antonio , Arlant Pedro , Salvestrini Júnior Arnaldo , Fernandez Angelo , Docema Marcos , Mattedi Rômulo , Silveira Thales , Caldas José , Fazzito Mirella 
Published: December 2017

Background Endometrial stromal sarcomas (ESSs) are the second most common uterine sarcomas. Although ESSs are often indolent, they have metastatic potential. To the best of our knowledge, there are only three reports of brain metastasis, and the present report is the first to describe a late skull metastasis of an ESS.
Case Report We describe the case of a 51-year-old woman who presented abnormal vaginal bleeding 14 years ago; she was diagnosed with an uterine mass and submitted to a hysterectomy. One year ago she presented ESS lung metastasis followed by a left parietal calvarial metastasis. The optimal treatment for metastatic ESS is controversial, but the use of progesterone and aromatase inhibitors is advisable.
Homöopathie bei klimakterischen Beschwerden
Authors: Boeddrich Ute 
Published: December 2017

ZusammenfassungDas Klimakterium der Frau kann, muss aber nicht zu einer Krise führen. Symptome wie Hitzewallungen, Schlaflosigkeit, Stimmungsschwankungen
bis hin zu Depressionen und Phobien lassen sich meist positiv mit Homöopathie in Kombination mit naturheilkundlichen Methoden der
Ordnungstherapie behandeln. Es kommen homöopathische Einzelmittel oder sogenannte fixe Kombinationen zum Einsatz. Ergänzend können außerdem
Phytotherapeutika und Verfahren aus der Komplementärmedizin eingesetzt werden. Sollten die genannten Maßnahmen nicht ausreichen, lassen sich
naturidentische Hormone oder konventionelle Hormongaben in den diversen Darreichungsformen wie Gels, Pflaster oder Tabletten für einen
begrenzten Zeitraum hilfreich nutzen.
Fehler und Schwächen in der Berichterstattung über epidemiologische Studien in Printmedien: Das Beispiel „Fleischkonsum und Darmkrebs“
Authors: Kowall Bernd , Stang Andreas 
Published: December 2017

Zusammenfassung
Hintergrund Über epidemiologische Studien wird häufig in den Medien berichtet, weil die Ergebnisse für viele Menschen von unmittelbarem Interesse sind. Es soll beispielhaft untersucht werden, ob die Ergebnisse epidemiologischer Studien in Printmedien verständlich und korrekt dargestellt werden.
Methode Sämtliche Berichte aus 13 ausgewählten deutschen Printmedien zum Thema Fleischkonsum und Darmkrebs, die im Anschluss an eine Pressemitteilung der IARC (International Agency for Research on Cancer) vom 26.10.2015 erschienen sind, werden unter dem Gesichtspunkt ihrer Verständlichkeit und Korrektheit ausgewertet. Zudem wird untersucht, nach welchen Kriterien die Printmedien die Aussagekraft der Forschungsergebnisse bewerten.
Ergebnisse 11 der 13 Printmedien übernahmen die Formulierung aus der Pressemitteilung, in der ein relatives Risiko angegeben wurde (18% Erhöhung des Darmkrebsrisikos pro 50 Gramm zusätzlichem Konsum von verarbeitetem Fleisch pro Tag). Da diese Formulierung von vielen Lesern möglicherweise als Erhöhung des absoluten Risikos um 18 Prozentpunkte missverstanden wird, ist die Angabe von absoluten Risiken sinnvoller. Absolute Risiken werden jedoch nur von 6 Printmedien korrekt angegeben. 5 Printmedien formulieren fälschlicherweise Schwellenwerte für den Fleischkonsum. Weitere Fehler liegen darin, die Indexgruppe ungenau zu beschreiben (etwa: „exzessive Fleischesser“ ohne Grammangabe), die Referenzgruppe nicht eindeutig zu benennen und darin, Zeiträume, für die ein Risiko berechnet wurde, nicht anzugeben. Wissenschaftsinterne Kriterien für die Bewertung der Qualität der epidemiologischen Studien wie Confounding und die Präzision bei der Erhebung des Fleischkonsums werden selten angeführt.
Schlussfolgerung Schon in Pressemitteilungen sollte auf eine verständliche Darstellung von Maßzahlen, Effektschätzern und wichtigen Fehlerquellen geachtet werden. Im konkreten Beispiel hätte eine höhere Qualität der Pressemitteilung der IARC – insbesondere das Benennen absoluter anstelle relativer Risiken – vermutlich eine weniger missverständliche Berichterstattung in den Printmedien zur Folge gehabt.
Ultraschall unter der Geburt: Eine systematische Analyse des Höhenstandes des kindlichen Kopfes in der Eröffnungsperiode der Geburt
Authors: Kohls Fabian , Brodowski Lars , Kuehnle Elna , Kniebusch Nadine , Kalache Karim , Weichert Alexander 
Published: December 2017

Zusammenfassung
Einleitung Die Höhenstandsbestimmung des fetalen Kopfes hat Einfluss auf das geburtshilfliche Management. Ziel der Studie war es mithilfe des angle of progression (AOP) in der Eröffnungsphase eine Aussage über Geburtsdauer und Geburtsmodus zu treffen.
Methodik Dies war eine prospektive Studie. Einschlusskriterien waren Einlingsschwangerschaften, spontan-vaginale Geburt, fetale Schädellage, Primi- und Multiparae und Patientinnen mit Periduralanästhesie (PDA). Einflussfaktoren wie Kopfumfang, Geburtsgewicht, Oxytocingabe, Periduralanästhesie, Parität wurden bestimmt und den Einfluss auf den AOP analysiert sowie drei Berechnungsvarianten erstellt.
Ergebnis 30 Patientinnen wurden eingeschlossen. Der Anteil an spontan-vaginalen Geburten lag bei 90%, die der vaginal-operativen bei 10%. Der Durchschnittswinkel des AOP lag bei den spontan-vaginalen Entbindungen bei einer Muttermundsweite <5 cm bei 100,9°, bei >5 cm bei 125,3°. Bei den vaginal-operativen Entbindungen lag der Durchschnittswinkel bei <5 cm bei 93°, bei>5 cm bei 113,9°. Nur die erste Berechnung AOP 1/Muttermundöffnung in cm bei der 1. Messung zeigt eine Tendenz zur Geburtsdauer, aber nicht zum Entbindungsmodus.
Fazit für die Praxis Die prognostische Aussagefähigkeit des Ultraschalls unter der Geburt in der Eröffnungsphase lässt Tendenzen zur Geburtsdauer erkennen.
Structural predictor for nonlinear sheared dynamics in simple glass-forming liquids
Authors: Ingebrigtsen Trond S. , Tanaka Hajime 
Published: December 2017

Significance
Fluidity is the key dynamical physical property of the liquid state and is characterized by the transport coefficient, viscosity. For slow flow, the viscosity of a liquid is generally independent of the flow rate. For fast flow, however, the behavior can be much more complicated; for example, supercooled liquids are known to exhibit a drastic decrease in viscosity under high flow rates, thus flowing more easily and dissipating less energy. Despite its fundamental and industrial importance, the physical mechanism behind this phenomenon known as “shear thinning” remains unknown. Here, we show that shear thinning is characterized only by the flow-induced change of the liquid structure along the extensional direction of the flow, providing a hint at understanding this long-standing unresolved problem.
For a multidimensional class analysis in Africa
Authors: Noret Joël 
Published: December 2017

SUMMARY
How can we analyse the dynamics of social structure in Africa today? This Debate piece argues that a Bourdieu-inspired, multidimensional class analysis opens promising perspectives for understanding class dynamics in Africa. This implies notably bridging objectivist and subjectivist approaches to class analysis, and working with a multidimensional idea of the social space.
A hybrid-hierarchical genome assembly strategy to sequence the invasive golden mussel, Limnoperna fortunei
Authors: Uliano-Silva Marcela , Dondero Francesco , Dan Otto Thomas , Costa Igor , Lima Nicholas Costa Barroso , Americo Juliana Alves , Mazzoni Camila Junqueira , Prosdocimi Francisco , Rebelo Mauro de Freitas 
Published: December 2017

Abstract

Background
For more than 25 years, the golden mussel, Limnoperna fortunei, has aggressively invaded South American freshwaters, having travelled more than 5000 km upstream across 5 countries. Along the way, the golden mussel has outcompeted native species and economically harmed aquaculture, hydroelectric powers, and ship transit. We have sequenced the complete genome of the golden mussel to understand the molecular basis of its invasiveness and search for ways to control it.

Findings
We assembled the 1.6-Gb genome into 20 548 scaffolds with an N50 length of 312 Kb using a hybrid and hierarchical assembly strategy from short and long DNA reads and transcriptomes. A total of 60 717 coding genes were inferred from a customized transcriptome-trained AUGUSTUS run. We also compared predicted protein sets with those of complete molluscan genomes, revealing an exacerbation of protein-binding domains in L. fortunei.

Conclusions
We built one of the best bivalve genome assemblies available using a cost-effective approach using Illumina paired-end, mate-paired, and PacBio long reads. We expect that the continuous and careful annotation of L. fortunei's genome will contribute to the investigation of bivalve genetics, evolution, and invasiveness, as well as to the development of biotechnological tools for aquatic pest control.