bluuebunny/crossref_metadata_2025_split huggingface dataset:
Interactions between Promazine and Antidepressants at the Level of Cellular Distribution
Authors: Daniel Władyslawa Anna , Wöjcikowski Jacek 
Published: October 2024

AbstractThe pharmacokinetic interactions in clinical combinations of a phenolhiazine neuroleptic and antidepressants at the level of cellular distribution were investigated. Uptake experiments were performed on slices of various rat tissues as a system with intact lysosomes. Promazine and antidepressants (imipramine, amitriptyline, sertraline, fluoxetine) were incubated separately or jointly with tissue slices for 1 hr. Initial concentration of each drug was 5 uM. The interaction studies were carried out in the absence and presence of ammonium chloride (20 mM), a lysosomotropic compound which increases the internal pH value of lysosomes. All the tissues known for their abundance of lysosomes (the lungs, liver, kidneys) were the site of an interaction between promazine and antidepressants. The neuroleptic and antidepressants mutually inhibited their tissue uptake. The potency of interference of each antidepressant with the lysosomal uptake of promazine was similar. The interactions did not occur in the presence of ammonium chloride, which indicates involvement of the lysosomal trapping. Carbamazepins a lipophilic but non‐lysosomotropic drug, did not interfere with the promazine uptake, and the adipose tissue containing very few lysosomes was never the site of interaction in our experiment. Distribution interactions were also observed in the brain and in some cases in muscles (the tissues less abundant of lysosomes), the effect of the inhibitory drug being usually more potent than that of ammonium chloride. Most of the interactions occurring in these two tissues were also observed in the presence of ammonium chloride, which suggests involvement, at least partially, of a non‐lysosomal trapping mechanism. The consequences of the observed distributive interactions at the level of lysosomal trapping in vitro are diminished intralysosomal concentration of the basic lipophilic psychotropic and its increase in cell membranes and fluids. In vivo, a shift from the organs or tissues rich in lysosomes to those less abundant in these organella, and an increase in the free drug concentration in body fluids may be expected. In conclusion, the obtained results show that, regardless of the previously known metabolic interactions between psychotropics, interactions at the levels of cellular and body distribution are also feasible.
The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism
Authors: Chen Qi , Wang Wen‐Yan , Xu Qing‐Yang , Dai Yan‐Fa , Zhu Xing‐Yu , Chen Zhao‐Yang , Sun Ning , Leung Chung‐Hang , Gao Fei , Wu Ke‐Jia 
Published: October 2024

AbstractPathological cardiac hypertrophy, a common feature in various cardiovascular diseases, can be more effectively managed through combination therapies using natural compounds. Harmine, a β‐carboline alkaloid found in plants, possesses numerous pharmacological functions, including alleviating cardiac hypertrophy. Similarly, Selenomethionine (SE), a primary organic selenium source, has been shown to mitigate cardiac autophagy and alleviate injury. To explores the therapeutic potential of combining Harmine with SE to treat cardiac hypertrophy. The synergistic effects of SE and harmine against cardiac hypertrophy were assessed in vitro with angiotensin II (AngII)‐induced hypertrophy and in vivo using a Myh6R404Q mouse model. Co‐administration of SE and harmine significantly reduced hypertrophy‐related markers, outperforming monotherapies. Transcriptomic and metabolic profiling revealed substantial alterations in key metabolic and signalling pathways, particularly those involved in energy metabolism. Notably, the combination therapy led to a marked reduction in the activity of key glycolytic enzymes. Importantly, the addition of the glycolysis inhibitor 2‐deoxy‐D‐glucose (2‐DG) did not further potentiate these effects, suggesting that the antihypertrophic action is predominantly mediated through glycolytic inhibition. These findings highlight the potential of SE and harmine as a promising combination therapy for the treatment of cardiac hypertrophy.
Involuntary childlessness in the U.S. and Israel: Pronatalism, gender, and sexual identity
Authors: Tate Doyle P. , Shenkman Geva 
Published: October 2024

AbstractObjectiveThis study examined experiences of involuntary childlessness as a function of sexual identity and gender in the United States (U.S.) and Israel.BackgroundSexual minority individuals may experience more involuntary childlessness than heterosexual people, and, to our knowledge, no studies have compared involuntary childlessness between the U.S., which is socially, but not politically pronatal, and Israel, which is both socially and politically pronatal.MethodTwo online surveys were distributed, one per country. The combined dataset was 1739 people (470 heterosexual men, 521 heterosexual women, 421 sexual minority men, and 327 sexual minority women). Differences in pronatalism, experiences of involuntary childlessness, and stress related to involuntary childlessness were assessed as a function of gender, sexual identity, and country.ResultsParticipants in the U.S. reported higher levels of pronatalism, more frequent involuntary childlessness, and greater stress from these experiences than did Israeli participants. In Israel, 68% of sexual minority people reported having experienced involuntary childlessness compared to 32% of heterosexual people. In the U.S., around 50% of people reported involuntary childlessness regardless of group. However, sexual minority individuals reported more frequent experiences of and stress from these experiences than did heterosexual people in both countries.ConclusionA concerning proportion of people in the U.S. and sexual minority adults in Israel experience involuntary childlessness. Overall, there are implications for the potential protective factor of effective fertility policies, such as in Israel, for those facing involuntary childlessness.
Rethinking Supply Chain Management in a Post‐Growth Era
Authors: Luzzini Davide , Pagell Mark , Devenin Veronica , Miemczyk Joe , Longoni Annachiara , Banerjee Bobby 
Published: October 2024

ABSTRACTSupply chain management is grounded on the assumption that endless economic growth is compatible with environmental and social sustainability. Yet scholars from ecological economics question this assumption due to ever increasing evidence showing how hard it is to decouple growth from negative environmental and social externalities. In response, pressure from social movements is mounting, and the agendas of several countries already consider alternatives to growth. Therefore, this article presents a critical thought experiment for the supply chain management discipline: What are the implications of moving from the current endless growth paradigm to a post‐growth paradigm for businesses and their supply chains? Using the umbrella term “post‐growth,” this article identifies three key post‐growth principles—(i) socio‐ecological wellbeing, (ii) selective downscaling, and (iii) systems thinking—and then examines their implications for supply chain management research and practice.
The polyphasic approach reveals ten novel and one known Ascomycota taxa from terrestrial agarwood‐producing trees
Authors: Du Tian‐Ye , Tibpromma Saowaluck , Hyde Kevin D. , Mapook Ausana , Dai Dong‐Qin , Zhang Gui‐Qing , Stephenson Steven L. , Suwannarach Nakarin , Kumla Jaturong , Elgorban Abdallah M. , Rajeshkumar Kunhiraman C. , Maharachchikumbura Sajeewa S. N. , Li Qiang , Karunarathna Samantha C. 
Published: October 2024

AbstractAquilaria (Thymelaeaceae), a tropical and subtropical plant, is one of the main genera that can produce agarwood. Aquilaria sinensis and Aquilaria yunnanensis are native Chinese tree species, and A. sinensis is China's main agarwood source. Agarwood is a nontimber forest product with high economic and medicinal value. First‐grade agarwood is sold as much as $100 000 per kilogram. There has been little research on the saprobic fungi associated with Aquilaria, with only 11 records having been reported. In the present study, 10 terrestrial saprobic fungi associated with A. sinensis and A. yunnanensis were collected in China. Based on morphological and phylogenetic studies, these 10 collections are introduced herein as one new genus (Aquilariomyces), nine new species – Aquilariomyces aquilariae, Corynespora aquilariae, Melomastia maomingensis, Nigrograna aquilariae, Parathyridariella aquilariae, Peroneutypa maomingensis, Phaeoseptum aquilariae, Pseudothyridariella aquilariae, and Triangularia aquilariae, and one known species (Camarographium clematidis). Descriptions, illustrations of morphological characteristics, photo plates, phylogenetic trees, and the results of a pairwise homoplasy index test (PHI) test results are provided.
Traits estimated when grown alone may underestimate the competitive advantage and invasiveness of exotic species
Authors: Zhu Biao , Wei Chunqiang , Zhou Hao , Chen Wei , Siemann Evan , Lu Xinmin 
Published: October 2024

Summary
Functional differences between native and exotic species, estimated when species are grown alone or in mixtures, are often used to predict the invasion risk of exotic species. However, it remains elusive whether the functional differences estimated by the two methods and their ability to predict species invasiveness (e.g. high abundance) are consistent.
We compiled data from two common garden experiments, in which specific leaf area, height, and aboveground biomass of 64 common native and exotic invasive species in China were estimated when grown individually (pot) or in mixtures (field).
Exotic species accumulated higher aboveground biomass than natives, but only when grown in field mixtures. Moreover, aboveground biomass and functional distinctiveness estimated in mixtures were more predictive of species persistence and relative abundance in the field mixtures in the second year than those estimated when grown alone.
These findings suggest that assessing species traits while grown alone may underestimate the competitive advantage for some exotic species, highlighting the importance of trait‐by‐environment interactions in shaping species invasion. Therefore, we propose that integrating multi‐site or multi‐year field surveys and manipulative experiments is required to best identify the key trait(s) and environment(s) that interactively shape species invasion and community dynamics.
The BpPP2C‐BpMADS11‐BpERF61 signaling confers drought tolerance in Betula platyphylla
Authors: Zhao Huimin , Jia Yaqi , Niu Yani , Wang Yucheng 
Published: October 2024

Summary
Plant MADS‐box proteins are vital for abiotic stress tolerance, yet their mechanisms for responding to drought remain poorly understood.
Here, we investigated the drought tolerance mechanism of a MADS‐box protein (BpMADS11) from birch (Betula platyphylla) using immunoprecipitation, Western blotting, yeast two‐hybrid, yeast one‐hybrid, ChIP, RNA‐seq, and dual‐luciferase assays to explore post‐translational modifications, protein interactions, and gene regulation.
Birch plants overexpressing BpMADS11 exhibited enhanced drought tolerance, while knockout lines displayed reduced tolerance. Under drought conditions, BpMADS11 interacts with protein phosphatase 2C22 (BpPP2C22), which dephosphorylates BpMADS11. Birch plants that overexpress BpMADS11 and lack BpPP2C22 show significantly reduced drought tolerance compared with those that only overexpress BpMADS11. BpMADS11 regulates the expression of BpERF61 by binding to CArG‐box in its promoter. The dephosphorylated BpMADS11 exhibits increased DNA binding ability and increased expression of BpERF61. Like BpMADS11, birch plants overexpressing BpERF61 show improved drought tolerance, while those with BpERF61 knockout exhibit decreased tolerance. BpERF61 binds to specific DNA motifs including ‘CACGTG’ (G‐box), ‘GGGCCCC’, and ‘TTGGAT’ to regulate the genes related to drought stress.
Collectively, BpMADS11 undergoes dephosphorylation through its interaction with BpPP2C22, prompting the expression of BpERF61. Subsequently, BpERF61 regulates downstream genes by binding to specific DNA motifs, thereby enhancing drought tolerance.
The association between public managers' type of education and prioritizing core service provision and communication
Authors: Netra Søren , Pihl‐Thingvad Signe , Winter Vera 
Published: October 2024

AbstractAn important question in public management is whether public organizations should prefer or avoid specialist managers (i.e., managers whose professional backgrounds match the work they oversee). Research has shown that specialist managers are associated with better field‐specific performance in public organizations, and theory suggests that they lead differently than nonspecialist managers. However, there is no empirical evidence to support this latter claim. To remedy this, we investigate whether specialist managers prioritize core service provision more and communicate better than nonspecialist managers. Through multilevel regressions of employee reports of leaders' behaviors in the contexts of schools, eldercare, daycare, and employment, we find that specialist managers prioritize core service provision more in all contexts but schools and communicate better in eldercare and employment but not elsewhere. These findings are consistent with the theoretical expectations and thus emphasize the importance of educational background in shaping managerial behavior.
On Population and the International Order
Authors: McNicoll Geoffrey 
Published: October 2024

AbstractThis essay expores demographic effects on the international order over the postwar decades and potentially through the next half‐century. Such effects derive from the relative sizes of populations and labor forces among states, contrasts in age distributions (resulting from the regionally staggered timing of fertility decline), and high levels of international migration, fueled by economic disparities and civil conflict. In coming decades, differential population growth and aging—in some states, entrenchment of population decline—will shift the global distribution of labor away from East Asia and Europe and toward South and West Asia and especially Africa. Short‐range migration may be pressed by environmental change; longer‐range migration toward rich countries, much of it illicit and already an intractable public policy issue in many of them, will face increased societal resistance and stronger efforts to police entry. The future international order will see a states system with the Global North further demographically marginalized; India as an emerging economic‐demographic superpower, joining a fast‐aging China and plausibly a less internationally engaged United States; and a demographically dominant Africa with as yet a wholly unclear place in the global political economy. Although not part of standard demographic projections, there are extreme global warming scenarios and other disaster eventualities that could be radically transformative of this order.
Cadmium Minimization in Crops: A Trade‐Off With Mineral Nutrients in Safe Breeding
Authors: Yan Huili , Peng Zhimei , Zhang Hezifan , Wang Binghan , Xu Wenxiu , He Zhenyan 
Published: October 2024

ABSTRACTCadmium (Cd) contamination poses a threat to global crop safety. To address this issue, researchers mainly focused on the Cd, explored mechanism of accumulation to low‐Cd breeding technologies and created several low‐Cd varieties over the past decades. However, new challenges have emerged, particularly the yield reduction due to disturbances in mineral nutrient balance. The goals of breeding have been transferred from a primary focus on ‘low‐Cd crops’ to ‘low‐Cd/nutrient‐balanced’ crops, which means limiting Cd content while maintaining other nutrient elements like iron (Fe), manganese (Mn) and zinc (Zn) at a proper content, thus to meet the future agricultural demands. Here, on a multielement perspective, we reviewed the mechanisms of Cd and mineral nutrient transport system in crops and summarized the research advances in Cd minimization through artificial mutations, natural variations and genetic engineering. Furthermore, the challenge of disruption of mineral nutrients in low‐Cd crops was discussed and two potential approaches designing Cd‐mineral nutrient‐optimized artificial transporters and pyramiding Cd‐mineral nutrient‐optimized variations were proposed. Aiming at addressing these challenges, these approaches represent promising advancements in the field and offer potential pathways for future research and development in the creation of safe and high‐quality crops.
Perspectives on childhood coronavirus disease vaccination in Japan and influencing factors
Authors: Lelliott Madoka , Sakata Masatsugu , Kohno Ayako , Toyomoto Rie , Matsumoto Ayuko , Furukawa Toshi A. 
Published: October 2024

AbstractBackgroundTo support parental decision‐making it is important to understand parents' perspectives on vaccination for their children and the factors that contribute to their vaccine hesitancy. There have been relatively few studies in this area in Japan, particularly with longitudinal and mixed methodologies.MethodsWe used an explanatory sequential mixed methods approach to describe longitudinal changes in vaccine acceptance and to explore factors associated with parental coronavirus 2019 (COVID‐19) vaccine hesitancy. We recruited parents who had children aged 6 months to 11 years old from five facilities in Japan. Two cross‐sectional online surveys and semi‐structured online interviews were conducted. Logistic regression analysis was used to explore factors associated with parents' vaccine hesitancy for their children, and thematic analysis was used to analyze the interview data.ResultsIn total, 134 parents responded to both online surveys and, of those, 10 participated in interviews. Acceptance rates of COVID‐19 vaccination for their children were 19.4% (26/134) at the first survey and 11.2% (15/134) at the second survey. Integration of the data identified that the main factors for vaccine hesitancy included vaccine safety, vaccine effectiveness, government policy, and recommendations from people close to parents.ConclusionsReadily available and more balanced information, and community‐wide support from people close to parents and familiar health‐care providers are likely to provide better support for parents' decision‐making. Further investigation is required on how to provide information in an easily understood manner.
Save the five: Meeting Taurek's challenge
Authors: Barnett Zach 
Published: October 2024

AbstractSix people are in trouble. We can save five of them or just the sixth. What should we do? John Taurek defends a radical view: We are not required to save the greater number. Taurek has persuaded some. But even the unpersuaded agree that Taurek poses a deep and important challenge: From where does the priority of the many derive? It seems difficult, or even impossible, to convince someone who denies the importance of the numbers… to care about the numbers. That's what this paper aims to do. It will argue that the priority of the many follows, with minimal other assumptions, from something all should accept: the modest premise that if we can improve one person's chance of survival—without affecting anyone else—we should.
Cyclodextrin‐Cholesterol Alone or in Combination With Cyclodextrin‐Vitamin E Improves Bull Sperm Cryopreservation in a Soybean Lecithin Extender
Authors: Boukhalfa Djemouai , Benhenia Karim , Sayah Asmaa , Kourat Ahcene , Safsaf Boubakeur 
Published: October 2024

ABSTRACTCombining cholesterol‐loaded methyl‐β‐cyclodextrin (CD‐CHL) with vitamin E‐loaded methyl‐β‐cyclodextrin (CD‐Vit E) to combat cold shock and oxidative stress during sperm cryopreservation in soybean lecithin extenders remains unexplored. Thus, the current study aimed to investigate the effect of treating bull sperm with CD‐CHL and CD‐Vit E prior to cryopreservation in a soybean lecithin extender. Sperm collected from eight fertile bulls were pooled and split into six aliquots. Five aliquots were treated, in a Tris‐based extender, with CD‐CHL (2 mg/120 × 106 cells/mL) and either 0, 0.5, 1.0, 1.5 or 2 mg CD‐Vit E/120 × 106 cells/mL. The control aliquot was diluted in a Tris‐based extender without further supplementation. After incubation at 22°C for 15 min and addition of a soybean lecithin extender, all aliquots were equilibrated for 2 h at 4°C and then cryopreserved in liquid nitrogen. Computer‐assisted sperm analysis (CASA) was used to explore the different sperm motility parameters, hypo‐osmotic swelling test to determine membrane functionality and fluorescein isothiocyanate‐conjugated Aeachis hypogaea (peanut) agglutinin (FITC‐PNA) to quantify acrosome integrity. The effect of oxidative stress on the sperm membrane was assessed through lipid peroxidation measurement. Compared to control, CD‐CHL alone improved significantly (p < 0.05) all CASA motility parameters, membrane functionality and acrosome integrity of thawed sperm. The membrane functionality was more significantly (p < 0.05) improved when 0.5 mg CD‐Vit E was combined with CD‐CHL. Concerning lipid peroxidation, no significant differences (p > 0.05) in malondialdehyde (MDA) levels were registered between groups. In conclusion, the combination of CD‐CHL and CD‐Vit E demonstrated a significant positive effect on the cryopreservation of bull sperm in a soybean lecithin extender.
What is known about suicide prevention gatekeeper training and directions for future research
Authors: Spafford Sarah G. , Silverman Morton M. , Gutierrez Peter M. 
Published: October 2024

AbstractIntroductionSuicide prevention training that teaches skills to support a person experiencing thoughts of suicide and create community support networks, often termed, “gatekeeper” training (GKT), has been a longstanding pillar of international, national, and local suicide prevention efforts. GKT aims to improve knowledge, attitudes, and self‐efficacy in identifying individuals at risk for suicide, hopefully enhancing one’s willingness and ability to intervene with a person experiencing a crisis. However, little is known about GKT’s effectiveness in creating the essential behavior change (e.g., increase in intervening behaviors) it sets out to accomplish.MethodsThis paper explores the history and theoretical background of GKT, reviews the current state of research on GKT, and provides framing and recommendations for next steps to advance research and practice around GKT.Results & ConclusionThrough positioning GKT appropriately within the field of suicide prevention, we argue that the field of suicide prevention needs more rigorous research around GKT that includes long‐term follow‐up data on usage of skills learned during training, data on outcomes of those who have received an intervention from a trained gatekeeper, and the integration of implementation science to further our understanding of which trainings are appropriate for which helpers.