bluuebunny/crossref_metadata_2025_split huggingface dataset:
Uterine Fibroids: Bridging Genomic Defects and Chronic Inflammation
Authors: El Andaloussi Abdeljabar , Chaudhry Zuni , Al-Hendy Ayman , Ismail Nahed 
Published: November 2017

AbstractUterine fibroids (UF; aka leiomyoma, myomas) are the most common benign tumors of female reproductive tract. They are highly prevalent, with 70 to 80% of women burdened by the end of their reproductive years. Fibroids are a leading cause of pelvic pain, abnormal vaginal bleeding, pelvic bulk symptoms, miscarriage, and infertility. They are the leading indication for hysterectomy, and costs exceed 34 billion dollars annually in the United States alone. Recently, somatic mutations in exons 1 and 2 of Med12 gene emerged as common UF driver mutations. Unfortunately, the detailed etiology of UF is not fully realized. Particularly, very little is known about possible dysregulation of inflammatory and immune processes and their possible contribution to UF pathogenesis. The notion on possible impact of altered estrogen and progesterone signaling in UF on inflammatory responses and DNA repair machinery that can conceivably lead to tumor-specific somatic mutation is indeed an intriguing concept which has some foundation in available observation in other hormonally responsive tissues. This review highlights and summarizes our current knowledge on the convergence of such pathways and their relevance for UF pathogenesis.
Patient-Centered Care and Uterine Fibroids
Authors: Marsh Erica , Chibber Shani , Saad Wael 
Published: November 2017

AbstractUterine leiomyomas are the most prevalent tumors in reproductive-aged women and are a major public health concern in the United States. Commonly known as fibroids, these benign tumors continue to be the leading cause of hysterectomy and are responsible for as much as $34 million in costs annually in the United States. Despite the increasing numbers of gains that are being made in understanding the pathophysiology of these tumors, relatively little work has been done to advance understanding of care delivery with regard to these tumors, specifically the patient perspective. Herein, we provide an overview of patient-centered care, a review of the available literature on the fibroid patient's perspective, and a discussion of opportunities to re-envision patient care with regard to fibroids.
Injury of the Carotid Artery during Endoscopic Endonasal Surgery: Surveys of Skull Base Surgeons
Authors: Rowan Nicholas , Turner Meghan , Valappil Benita , Fernandez-Miranda Juan , Wang Eric , Gardner Paul , Snyderman Carl 
Published: November 2017

Objectives This study aimed to review endoscopic skull base surgeon experience with internal carotid artery (ICA) injuries during endoscopic endonasal surgery (EES) to provide an estimate of the incidence of ICA injury, the associated factors and identify the best training modalities for the management of this complication.
Design Anonymous electronic survey of past participants at a well-established endoscopic skull base surgery course and a global online community of skull base surgeons.
Main Outcome Measures Relative incidence of ICA injuries during EES, associated anatomic and intraoperative factors, and surgeon experience.
Results At least 20% of surgeons in each surveyed population experienced a carotid artery injury. Reported carotid artery injuries were most common during tumor exposure and removal (48%). The parasellar carotid artery was the most commonly injured segment (39%). Carotid artery injuries were more common in high-volume surgeons, but only statistically significant in one of the two populations. Attendance at a skull base course or courses did not change the incidence of carotid artery injury in either surveyed population. In both surveys, respondents preferred live surgeries or active (not computer simulated) training models.
Conclusions ICA injury is underreported and most common when manipulating the parasellar carotid artery for exposure and tumor dissection. Given the high morbidity and mortality associated with these injuries, vascular injury management should be prioritized and taught in a graduated approach by modern endoscopic skull base courses.
A Practical Approach to Neonatal Opiate Withdrawal Syndrome
Authors: Davis Jonathan , Devlin Lori 
Published: November 2017

AbstractPerinatal opioid misuse and neonatal opioid withdrawal syndrome (NOWS) are a significant public health problem that has grown exponentially over the past decade. In the United States, a woman seeks emergency room care for prescription opioid misuse every 3 minutes and approximately every 25 minutes, a child is born with signs of drug withdrawal. The economic impact of perinatal opioid misuse is significant with annual hospital charges for NOWS in 2012 as $1.5 billion dollars. Perinatal opioid misuse is a complex, multifaceted problem that demands a multidisciplinary cross specialty approach. This article will review the current state of NOWS and provide medical practitioners with a practical guide to enhance evidence based practice.
Impact of Papillary Muscle Infarction on Ischemic Mitral Regurgitation Assessed by Magnetic Resonance Imaging
Authors: Bretschneider Christiane , Heinrich Hannah-Klara , Seeger Achim , Burgstahler Christof , Miller Stephan , Kramer Ulrich , Gawaz Meinrad , Nikolaou Konstantin , Klumpp Bernhard 
Published: November 2017

Objective Ischemic mitral regurgitation is a predictor of heart failure resulting in increased mortality in patients with chronic myocardial infarction. It is uncertain whether the presence of papillary muscle (PM) infarction contributes to the development of mitral regurgitation in patients with chronic myocardial infarction (MI). The aim of the present study was to assess the correlation of PM infarction depicted by MRI with mitral regurgitation and left ventricular function.
Methods and Materials 48 patients with chronic MI and recent MRI and echocardiography were retrospectively included. The location and extent of MI depicted by MRI were correlated with left ventricular function assessed by MRI and mitral regurgitation assessed by echocardiography. The presence, location and extent of PM infarction depicted by late gadolinium enhancement (LGE-) MRI were correlated with functional parameters and compared with patients with chronic MI but no PM involvement.
Results PM infarction was found in 11 of 48 patients (23 %) using LGE-MRI. 8/11 patients (73 %) with PM infarction and 22/37 patients (59 %) without PM involvement in MI had ischemic mitral regurgitation. There was no significant difference between location, extent of MI and presence of mitral regurgitation between patients with and without PM involvement in myocardial infarction. In 4/4 patients with complete and in 4/7 patients with partial PM infarction, mitral regurgitation was present. The normalized mean left ventricular end-diastolic volume was increased in patients with ischemic mitral regurgitation.
Conclusion The presence of PM infarction does not correlate with ischemic mitral regurgitation. In patients with complete PM infarction and consequent discontinuity of viable tissue in the PM-chorda-mitral valve complex, the probability of developing ischemic mitral regurgitation seems to be increased. However, the severity of mitral regurgitation is not increased compared to patients with partial or no PM infarction.
Key points
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Comparison of the Effect of Cold Drink and Dexamethasone, and their Combined Effect on Children with Croup
Authors: Faraji-Goodarzi Mojgan , Taee Nadereh , Mohammadi-Kamalvand Mehrnoosh 
Published: November 2017

Abstract
Aims Croup is a clinical syndrome which included inspiratory stridor, coughing with a dog-like sound, noise obstruction and respiratory distress symptoms. This present study was conducted to compare the effects of cold drink and dexamethasone, and the effects of their co-administration on children’s croup.
Materials and Methods In this study, all patients with croup admitted to the emergency ward of Madani Hospital Khorramabad were divided through the simple randomized method into 3 groups after informed consents were taken from their parents. The first group was given cold drink, second group with dexamethasone (DM), and the third group were given the combined treatment simultaneously. The patients in the first and second groups who did not show signs of improvement received the simultaneous treatment similar to the third group. The data were analyzed using the SPSS software through descriptive statistics and inferential statistics including multi-field variance analysis and co-variance analysis.
Result The results of the study indicated a statistically significant between the 3 group in terms of improvement time-scale of croup clinical symptoms (P=0.001). There was no significant difference observed between the effects of other variables on improvement time-scale of croup clinical symptoms.
Conclusion The cold drink has less treating effect than DM and combined simultaneous treatment method. Also, DM had more influence than simultaneous treatment method. In addition, other variables including age, sex, birth weight, BMI, respiratory allergy and previous croup history did not influenced improvement time-scale and only type of intervention influenced improvement time-scale of croup clinical symptoms.
ω-3 Fettsäuren, Selen, Quecksilber: Können wir noch Fisch essen?
Authors: Friedrichsen Hans-Peter 
Published: November 2017

SummaryFisch liefert wichtige Nährstoffe, insb. die ω-3-Fettsäuren Eicosapentaensäure (EPA) und Docosahexaensäure (DHA) und kann das Risiko für zahlreiche chronische Erkrankungen verringern. Allerdings ist er zunehmend mit Schwermetallen belastet. Der Selen- und Quecksilbergehalt im Fisch entscheidet über Nutzen und Risiko.
Volumetric Assessment of Swallowing Muscles: A Comparison of CT and MRI Segmentation
Authors: Sporns Kim , Hanning Uta , Schmidt Rene , Muhle Paul , Wirth Rainer , Zimmer Sebastian , Dziewas Rainer , Suntrup-Krueger Sonja , Sporns Peter , Heindel Walter , Schwindt Wolfram 
Published: November 2017

Purpose Recent retrospective studies have proposed a high correlation between atrophy of swallowing muscles, age, severity of dysphagia and aspiration status based on computed tomography (CT). However, ionizing radiation poses an ethical barrier to research in prospective non-patient populations. Hence, there is a need to prove the efficacy of techniques that rely on noninvasive methods and produce high-resolution soft tissue images such as magnetic resonance imaging (MRI). The objective of this study was therefore to compare the segmentation results of swallowing muscles using CT and MRI.
Methods Retrospective study of 21 patients (median age: 46.6; gender: 11 female) who underwent CT and MRI of the head and neck region within a time frame of less than 50 days because of suspected head and neck cancer using contrast agent. CT and MR images were segmented by two blinded readers using Medical Imaging Toolkit (MITK) and both modalities were tested (with the equivalence test) regarding the segmented muscle volumes. Adjustment for multiple testing was performed using the Bonferroni test and the potential time effect of the muscle volumes and the time interval between the modalities was assessed by a spearman correlation. The study was approved by the local ethics committee.
Results The median volumes for each muscle belly of the digastric muscle derived from CT were 3051 mm3 (left) and 2969 mm3 (right), and from MRI they were 3218 mm3 (left) and 3027 mm3 (right). The median volume of the geniohyoid muscle was 6580 mm3 on CT and 6648 mm3 on MRI. The interrater reliability was high for all segmented muscles. The mean time interval between the CT and MRI examinations was 34 days (IQR 25; 41). The muscle differences of each muscle between the two modalities did not reveal significant correlation to the time interval between the examinations (digastric left r = 0.003 and digastric right r = –0.008; geniohyoid muscle r = 0.075).
Conclusion CT-based segmentation and MRI-based segmentation of the digastric and geniohyoid muscle are equally feasible. The potential advantage of MRI for prospective studies is the absence of ionizing radiation.
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Nano-drug for Pain Medicine
Authors: Hasanzadeh-Kiabi Farshad 
Published: November 2017

AbstractPain is commonly categorized into two diverse groups: acute pain, characterized by early onset and last for a very short time; while chronic pain, characterized by a prolonged pain for least 3 months’ duration. Timely and immediate management of critical pain is critical in reducing its aggravation to chronic pain. There has been successful application of nano-technology, nano-medicine to the treatment and management of pain both in clinical and experimental studies like the fabrication of nano-formulated liposomes to deliver drugs for pain therapy, formulation of non- steroidal anti-inflammatory drugs (NSAIDs). However safety issues related with NSAIDs have impelled the fabrication and the design of new drug formulations that reduces side effects and sustain efficacy. This review will give a concise summary on the available studies on the application of nano-formulated drugs designed for pain treatment and management.
Global science, national research, and the question of university rankings
Authors: Hazelkorn Ellen , Gibson Andrew 
Published: November 2017

AbstractScience has always operated in a competitive environment, but the globalisation of knowledge and the rising popularity and use of global rankings have elevated this competition to a new level. The quality, performance and productivity of higher education and university-based research have become a national differentiator in the global knowledge economy. Global rankings essentially measure levels of wealth and investment in higher education, and they reflect the realisation that national pre-eminence is no longer sufficient. These developments also correspond with increased public scrutiny and calls for greater transparency, underpinned by growing necessity to demonstrate value, impact and benefit. Despite on-going criticism of methodologies, and scepticism about their overall role, rankings are informing and influencing policy-making, academic behaviour, stakeholder opinions—and our collective understanding of science. This article examines the inter-relationship and tensions between the national and the global in the context of the influences between higher education and global university rankings. It starts with a discussion of the globalisation of knowledge and the rise of rankings. It then moves on to consider rankings in the context of wider discourse relating to quality and measuring scholarly activity, both within academia and by governments. The next section examines the relationship and tensions between research assessment and rankings, in policy and practice. It concludes by discussing the broader implications for higher education and university-based research.
Quantifying the limits of transition state theory in enzymatic catalysis
Authors: Zinovjev Kirill , Tuñón Iñaki 
Published: November 2017

Significance
Transition state theory (TST) is the most popular theory to calculate the rates of enzymatic reactions. However, in some cases TST could fail due to the violation of the nonrecrossing hypothesis at the transition state. In the present work we show that even for one of the most controversial enzymatic reactions—the hydride transfer catalyzed by dihydrofolate reductase—the error associated to TST represents only a minor correction to the reaction rate. Moreover, this error is actually larger for the reaction in solution than in the enzymatic active site. Based on this finding and on previous studies we propose an “enzymatic shielding” hypothesis which encompasses various aspects of the catalytic process.
Mocking fakeness
Authors: Halonen Mia , Pietikäinen Sari 
Published: November 2017

AbstractPhonetic resources, like dialects and accents, are used in ethnic humour to build up a recognisable character that pokes fun at the stereotypes associated with a particular identity, sometimes with critical and political undertones. In this article, we examine the manipulation of one such resource, aspiration, used in performing and mocking one such clichéd character, called thefake Sámi.This character has a contested history in Finnish tourism and marketing practices, and is embedded in a long-standing debate about who can use emblems of Sámi identity for economic purposes. Adopting a sociophonetic language regard and folk linguistics approaches (Preston 2010;Niedzielski & Preston 2003) we explore how “fakeness” is constructed phonetically by the actors performing “Fake Sámi” in an indigenous Sámi television comedy show during a period of intense political debate in Finland over the legal definition of the category of indigenous Sámi. By analysing the use of hyperbolic aspiration of a prominent feature of Lappish Finnish dialect, the non-initial syllable /h/-sound, we show how the fakeness is performed by evoking linguistic stereotypes of a Finnish Lappish dialect and a Finnish English accent by a deliberate misuse of aspiration: aspirating when standard phonemes in speech should not be aspirated and not aspirating when phonemes should be aspirated. We argue that this kind of deliberate ambivalence and misuse of phonetic resources is a phonetic resource for reflexive postmodern identity performances.
Defective interaction between p27 and cyclin A-CDK complex in certain human cancer cell lines revealed by split YFP assay in living cells
Authors: Chibazakura Taku , Asano Yuichi 
Published: November 2017

Abstract
Cyclin–cyclin dependent kinase (CDK) complex is negatively regulated by interaction with CDK inhibitors (CKIs). p27 protein is a major CKI in mammals and its down-regulation correlates with malignant transformation. However, some cancer cells express p27 at normal level, suggesting not only quantitative but qualitative control of p27, although little is known about such control. We analyzed the interaction between p27 and cyclin A (CycA)-CDK complex in living human cell lines, using a split yellow fluorescent protein (YFP) system in which the YFP fluorescence solely depends on p27-CycA binding. Introduction of this system into various cancer cell lines revealed that certain cell lines show no detectable YFP fluorescence. Furthermore, these cell lines exhibited reduced p27-CycA interaction as evaluated by immunoprecipitation, while they showed normal co-localization of both proteins. These results suggest that some cancer cells are defective for efficient interaction between p27 and CycA–CDK complex due to qualitative alteration(s).
Inhibitory effects of food additives derived from polyphenols on staphylococcal enterotoxin A production and biofilm formation by Staphylococcus aureus
Authors: Shimamura Yuko , Hirai Chikako , Sugiyama Yuka , Shibata Masaharu , Ozaki Junya , Murata Masatsune , Ohashi Norio , Masuda Shuichi 
Published: November 2017

Abstract
In this study, we examined the inhibitory effects of 14 food additives derived from polyphenol samples on staphylococcal enterotoxin A (SEA) production and biofilm formation by Staphylococcus aureus. Tannic acid AL (TA), Purephenon 50 W (PP) and Polyphenon 70A (POP) at 0.25 mg/mL and Gravinol®-N (GN), Blackcurrant polyphenol AC10 (BP), and Resveratrol-P5 (RT) at 1.0 mg/mL significantly decreased SEA production by S. aureus C-29 (p &lt; 0.05). TA, GN, BP, and RT significantly inhibited the expression of the sea gene in S. aureus C-29 (p &lt; 0.05), while suppression attempts by PP and POP proved unsuccessful. After result analysis, it can be derived that TA, GN, BP, and RT inhibit the production of SEA. Of the six samples, each one significantly inhibited biofilm formation (p &lt; 0.05). Food additives derived from polyphenols have viability to be used as a means to inhibit the enterotoxin production and control the biofilm formation of foodborne pathogens.
Bilateral comparison of 1 Ω and 10 kΩ standards (ongoing BIPM key comparisons BIPM.EM-K13.a and 13.b) between the SMD (Belgium) and the BIPM
Authors: Rolland Benjamin , Fletcher Nick , Vlad Dana 
Published: November 2017

This report gives the result of a bilateral comparison of resistance between the SMD (Belgium) and the BIPM carried out in 2017. Two 1 Ω and two 10 kΩ travelling standards belonging to the BIPM were used. The comparison was carried out with an 'A-B-A' pattern of measurements; the standards were measured first at the BIPM for a period of about one month, then for a similar period at the SMD, and finally again at the BIPM. The measurand was the 4 terminal dc resistance at low power. The BIPM was the pilot laboratory, and the comparison forms part of the ongoing BIPM key comparisons BIPM.EM-K13.a (for 1 Ω) and BIPM.EM-K13.b (for 10 kΩ).
The results from the SMD and the BIPM were found to be in good agreement, with a difference smaller than the relative expanded uncertainty (95% confidence, k = 2) of 0.080 × 10−6 for 1 Ω and 0.068 × 10−6 for 10 kΩ.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
Update of the BIPM comparison BIPM.RI(II)-K1.Am-241 of activity measurements of the radionuclide 241Am to include the 2009 results of the POLATOM (Poland), MKEH (Hungary) and the 2011 results of the LNE-LNHB (France)
Authors: Michotte C , Ratel G , Courte S , Dzeil T , Listkowska A , Csete I , Rózsa K , Szücs L , Zsinka A , Fréchou C , Bobin C , Pierre S 
Published: November 2017

Since 2009, three national metrology institutes (NMI) have submitted three samples of known activity of 241Am to the International Reference System (SIR) for activity comparison at the Bureau International des Poids et Mesures (BIPM), with comparison identifier BIPM.RI(II)-K1.Am-241. The values of the activity submitted were between about 3 MBq and 38 MBq. These three results replace their earlier results obtained in the linked CCRI(II)-K2.Am-241 in 2003. There are now five results in the BIPM.RI(II)-K1.Am-241 comparison, 16 results remaining from the CCRI(II)-K2.Am-241 comparison and two results in the COOMET.RI(II)-K2.Am-241 comparison. The degrees of equivalence between each equivalent activity measured in the SIR and the KCRV dating 2007 have been calculated and the results are given in the form of a table. A graphical presentation is also given.

Main text

To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm.org/.
The final report has been peer-reviewed and approved for publication by the CCRI, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).