bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma
Authors: Dreyling Martin , Santoro Armando , Mollica Luigina , Leppä Sirpa , Follows George A. , Lenz Georg , Kim Won Seog , Nagler Arnon , Panayiotidis Panayiotis , Demeter Judit , Özcan Muhit , Kosinova Marina , Bouabdallah Krimo , Morschhauser Franck , Stevens Don A. , Trevarthen David , Giurescu Marius , Cupit Lisa , Liu Li , Köchert Karl , Seidel Henrik , Peña Carol , Yin Shuxin , Hiemeyer Florian , Garcia-Vargas Jose , Childs Barrett H. , Zinzani Pier Luigi 
Published: October 2017

Purpose Phosphatidylinositol 3-kinase (PI3K) signaling is critical for the proliferation and survival of malignant B cells. Copanlisib, a pan-class I PI3K inhibitor with predominant activity against PI3K-α and -δ isoforms, has demonstrated efficacy and a manageable safety profile in patients with indolent lymphoma. Patients and Methods In this phase II study, 142 patients with relapsed or refractory indolent lymphoma after two or more lines of therapy were enrolled to receive copanlisib 60 mg intravenously on days 1, 8, and 15 of a 28-day cycle. The primary end point was objective response rate; secondary end points included duration of response, progression-free survival, and overall survival. In addition, safety and gene expression were evaluated. Results Median age was 63 years (range, 25 to 82 years), and patients had received a median of three (range, two to nine) prior regimens. The objective response rate was 59% (84 of 142 patients); 12% of patients achieved a complete response. Median time to response was 53 days. Median duration of response was 22.6 months, median progression-free survival was 11.2 months, and median overall survival had not yet been reached. The most frequent treatment-emergent adverse events were transient hyperglycemia (all grades, 50%; grade 3 or 4, 41%) and transient hypertension (all grades, 30%; grade 3, 24%). Other grade ≥3 events included decreased neutrophil count (24%) and lung infection (15%). High response rates to copanlisib were associated with high expression of PI3K/B-cell receptor signaling pathway genes. Conclusion PI3K-α and -δ inhibition by copanlisib demonstrated significant efficacy and a manageable safety profile in heavily pretreated patients with relapsed or refractory indolent lymphoma.
Use of cryopreserved umbilical cord with negative pressure wound therapy for complex diabetic ulcers with osteomyelitis
Authors: Raphael A. , Gonzales J. 
Published: October 2017

Objective: The objective of this study was to evaluate the combined use of cryopreserved human umbilical cord (cUC) allograft and negative pressure wound therapy (NPWT) in treating complex diabetic foot ulcers (DFUs) with bone exposure and osteomyelitis. These types of wound are known to carry a high morbidity and mortality. Methods: A single-center, retrospective chart review was performed to assess the efficacy of the combined use of cUC with NPWT, by the same surgeon, to help promote the closure of complex DFUs presenting with biopsy-proven osteomyelitis. Change in wound size and volume, time to wound closure, and number of cUC applications were assessed. Results: We identified of 14 wounds in 13 patients, with an average initial wound area of (mean±standard devaition) 33.2±21.7cm2 and wound volume of 52±26.2cm3. All achieved complete re-epithelialisation with an average time to closure of 24.0±10.9 weeks, using between 2–5 cUC applications. No adverse events were noted and none of the wounds required limb amputation during the a follow-up of 24 months for each patient. Conclusion: The results suggest that combined use of cUC and NPWT may be effective in improving the healing of complex DFUs that present with osteomyelitis. Prospective, randomised controlled trials are warranted to confirm this efficacy as well as its potential applications in other chronic wounds.
Wound healing outcomes in a diabetic foot ulcer outpatient clinic at an acute care hospital: a retrospective study
Authors: Lu S.H. , McLaren A-M. 
Published: October 2017

Objective: Patients with diabetic foot ulcers (DFU) have an increased risk of lower extremity amputation. A retrospective chart review of patients with DFUs attending the Foot Treatment and Assessment chiropodist-led outpatient clinic at an inner-city academic hospital was conducted to determine wound healing outcomes and characteristics contributing to outcomes. Method: We reviewed the complete clinical history of 279 patients with 332 DFUs spanning over a five-year period. Results: The mean age of patients was 61.5±12.5 years and most patients (83.5%) had one DFU. The majority of wounds (82.5%) were in the forefoot. Overall, 267/332 (80.5%) wounds healed. A greater proportion of wounds healed in the forefoot (82.5%) and midfoot (87.1%) than hindfoot (51.9%; p<0.001). Using a logistic regression model, palpable pedal pulse and use of a total contact cast were associated with better wound healing. Conclusion: Our findings are the first to demonstrate the benefits of chiropodists leading an acute care outpatient clinic in the management of DFUs in Canada and delivers wound healing outcomes equivalent to or exceeding those previously published.
Influence of substrate base on sports field covered with bermuda grass
Authors: Mateus Caroline De Moura D’Andréa , Tavares Armando Reis , Oliveira Maurício Roberto de , Jacon Camila Paula Rossetto Pescatori , Sartori Maria Márcia Pereira , Fernandes Dirceu Maximino , Bôas Roberto Lyra Villas 
Published: October 2017

The sports field consists of three layers (sub-base, base (substrate) and grass). The base is responsible for the radicular development of the grass, directly influencing the characteristics that provide quality, water drainage and lawn durability and allows athlete performance. The construction of sports field base generally follows USGA (United States Golf Association) recommendations for golf course greens. Sand is the main component based on its high capacity for drainage. This study aimed to define the best composition of the base for sports fields covered with Bermuda grass. The following treatments were evaluated: T1: sand; T2: sand (80%) + peat (20%); T3: sand (90%) + clay soil (10%); T4: sand (70%) + sandy soil (30%) during 12 months. The experimental design consisted of a randomized block design, with a 4 x 12 factorial design (treatments x months), with 3 replicates and each plot measuring 3 x 4 m. During one full year, the following parameters were evaluated: surface traction of the turf, mechanical resistance of the base to penetration, humidity of the base, concentration of nutrients in grass clippings, and chemical analysis of the base. The tallest grass occurred in substrate of sand mixed with peat. This mixture also promoted the highest N and P levels in the leaves of Bermuda grass. Playability of the sports field, as determined by mechanical strength and surface traction, was unaffected by the type of substrate. The presence of peat, sand and clay soil mixed with sand promoted greater water retention at the base.
Intoxicaciones por detergentes tipo “pod”: un nuevo riesgo a considerar
Authors: Escorcia García Clara Lucia , Berrouet Mejia Marie Claire 
Published: October 2017

Las intoxicaciones son una causa frecuente de consulta a los servicios de urgencias. En Colombia, el Sistema Nacional de Vigilancia en Salud Pública (SIVIGILA) ha reportado su aumento. Hasta la semana epidemiológica 41 del año 2016, se habían reportado 27,117 casos de intoxicación, con una ocurrencia de 55.6 por cada 100.000 habitantes, en su mayoría por medicamentos.
La población pediátrica está expuesta a diversos xenobióticos por sus actividades exploratorias, entre los cuales se cuentan los productos de limpieza. Los detergentes tipo “pod” (detergentes encapsulados) han ganado popularidad en nuestro país; uno de los riesgos que presenta esta clase de detergentes es su empaque, el cual guarda similitud con la apariencia de un dulce, lo cual lo hace atractivo a los niños, aumentando el riesgo de exposiciones accidentales.
Tradicionalmente se ha considerado que los productos de limpieza tienen bajo potencial de letalidad, sin embargo, hay nueva evidencia que demuestra que las intoxicaciones por detergentes generan riesgos gastrointestinales, neurológicos, metabólicos, respiratorios y renales, por lo cual es importante cambiar el paradigma de que los detergentes no tienen una toxicidad importante.
Uso y actitudes frente a los medicamentos naturales y homeopáticos en pacientes pediátricos: una encuesta entre médicos colombianos
Authors: Moreno Carlos Arturo , Riveros Huckstadt María Pilar 
Published: October 2017

Antecedentes. El uso de la medicina complementaria y alternativa (MCA) ha ido en aumento en todo el mundo, no sólo en adultos, sino también en niños. A pesar del fuerte interés en la MCA, existe poca información publicada sobre su uso en la práctica clínica, especialmente para países no angloparlantes y para la población pediátrica.
Objetivos Para comprender mejor el uso, el conocimiento y la actitud de los médicos con respecto a los medicamentos naturales y la homeopatía, se llevó a cabo una encuesta internacional con participación de pediatras y médicos generales que atendían pacientes pediátricos en 6 países: Alemania, Rusia, Bulgaria, España, Colombia e Israel. En el presente trabajo, sólo los datos asociados a Colombia se analizan y comparan con los resultados generales.
Métodos. La encuesta internacional fué realizada mediante un enfoque de múltiples países. Los datos fueron recolectados entre mayo y junio de 2014 mediante un cuestionario en línea estructurado y gestionado para pediatras y médicos generales que atendían niños.
Resultados. En Colombia, un total de 51 médicos participaron en la encuesta: el 80 % de los encuestados eran pediatras y el 20 % eran médicos generales o médicos de atención primaria. El 12.7 % de las prescripciones y/o recomendaciones pediátricas estaban relacionadas con preparados homeopáticos, y el 8.6 % estaban relacionadas con la fitoterapia. Los medicamentos naturales y la homeopatía se usan comúnmente junto con los fármacos convencionales/tradicionales. Las enfermedades más comunes tratadas con homeopatía fueron infecciones del tracto respiratorio superior (42 %), las alergias (39 %), las infecciones recurrentes (35 %), los trastornos del sueño (32 %), los problemas abdominales agudos (26%), el cólico infantil (23 %) y los problemas de comportamiento (19 %). Los pacientes más representativos tratados con medicamentos naturales eran niños con padres preocupados por los efectos secundarios de los medicamentos convencionales (30 %), y que optaban por el uso de medicinas naturales para ellos mismos (40 %). Se reportó una ligera tendencia al uso de medicamentos naturales en los pacientes más jóvenes (0 a 6 años) con enfermedades crónicas.
Conclusiones. La actitud hacia la MCA entre los profesionales de la salud en Colombia parece positiva. Es notable la diferencia entre los medicamentos homeopáticos y fitoterapéuticos: a pesar del uso tradicional de las plantas medicinales, en Colombia existen más prescripciones para homeopatía que para fitoterapia.
The impact of periodized core training program on accurate service velocity of male tennis players aged 11-13<p>11-13 yaş arası erkek tenisçilerde periyotlanmış core antrenman programının isabetli servis hızına etkisi
Authors: Sever Ozan , Kır Rıdvan , Yaman Metin 
Published: October 2017

The purpose of this study is to examine the effect of periodized core training program on the serve velocity in male tennis players aged 11-13 years. 24 male nationally ranged (age 11.9±1.63, height 154.4±11.32, weight 43±8.76) participated to the study from a professional tennis club. Pre-post-training - control group design was applied and subjects were randomly assigned to Control Group and Training Group. Training Group participated to the core training program consisted of isometric and isotonic core stabilization exercises on stable and nonstable surfaces, three days in a week for 8 weeks in addition to tennis training sessions. Accurate service velocity, was assessed initially and at the end of the 8-week core program for both control and training groups. There was a significant improvement (6.6 %) in the serve velocity for the training group after the experiment, whereas there were no differences in the control group. Core stabilization training improved service velocity for young tennis players. It is recommended tennis coaches to apply periodized core stabilization exercises to young athletes and plan training programs in this way. Extended English abstract is in the end of PDF (TURKISH) file. ÖzetBu çalışmanın amacı 11-13 yaş arası erkek tenisçilerde periyodlanmış core antrenman programının isabetli servis hızına etkisini incelemektir. Çalışmaya profesyonel bir tenis kulübünden ulusal müsabık 24 erkek tenisçi (yaş 11.9±1.63, boy 154.4±11.32, ağırlık 43±8.76) katılmıştır. Araştırmada ön-test son-test kontrol gruplu model uygulanmış, denekler iki gruba rastgele atanmıştır. 12 sporcu Kontrol Grubunu, 12 sporcu ise Deney Grubunu oluşturmuştur. Deney Grubuna haftanın üç günü yarım saatlik 8 hafta boyunca toplamda 24 antrenman birimi stabil ve stabil olmayan yüzeylerde izometrik ve izotonik core stabilizasyon egzersizlerinden oluşan program, tenis antrenmanlarına ek olarak uygulanmıştır. Program öncesi ve sonrasında her katılımcı maksimal hızda 10 servis kullanarak en hızlı ve geçerli atışları kaydedilmiştir. Core antrenman uygulaması sonrası Kontrol Grubunun servis atış hızı değişmezken, Deney Grubu servis atış hızını ortalama 120.93 km/s hızdan 128.6 km/s hıza (% 6.6) çıkarmıştır. Core antrenman uygulamalarının genç tenisçilerde isabetli servis hızını olumlu etkilediği tespit edilmiştir. Tenis antrenörlerinin yüksek şiddet içermeyen, core antrenmanlarını ve stabilizasyon uygulamalarını genç sporcularda uygulamasının yararlı olacağı düşünülmekte ve antrenman programlarını buna göre planlamaları tavsiye edilmektedir.
Early Diagnosing and Treatment of Rheumatoid Arthritis, Benefits of Anti-Citrullinated Peptides Examination
Authors: Belakova Gabriela , Manka V. , Zanova E. , Racay P. 
Published: October 2017

Abstract
Background: Anti-citrullinated peptides antibodies (ACPA) are specific for rheumatoid arthritis and have been implicated in disease pathogenesis. ACPA examination is a new component of ACR/EULAR 2010 classification criteria for rheumatoid arthritis. ACPA positivity predicts a more erosive disease course with severe joint damage and extra-articular manifestations. Objectives: To evaluate the benefits of ACPA examination in patients with early undifferentiated arthritis and patients with rheumatoid arthritis. Methods: We examined patients with arthritis and tested them for ACPA positivity. In every individual patient we evaluated if ACPA examination was necessary to establish the diagnosis of rheumatoid arthritis, or to change treatment, or if the diagnosis could have been established without ACPA examination (ACR/EULAR 2010 classification criteria was met without ACPA scoring). Results and Conclusions: We examined 833 patients with arthritis. There were 43 patients, or 62 % of a subgroup of 69 who were ACPA positive whose ACPA examination was not needed - ACR/EULAR criteria was met without ACPA scoring. This number represents 5.1 % of the total number examined. There were 15 patients, or 22 % of the subgroup and 1.8 % of the total whose diagnosis was revised to rheumatoid arthritis due to ACPA positivity - ACR/EULAR criteria was met solely with ACPA scoring. There were 11 patients (16 % and 1.3 %) whose medication was changed due to ACPA positivity. ACPA examination is useful in 3,1 % of all examined patients. When we correlate data on ACPA positive patients, 38 % of the patients profit from ACPA examinations. Considering the relatively low price of ACPA testing, this examination should not be excluded.
Selected Oxfordian brachiopods from Zalas (Cracow Upland, Poland)
Authors: Radwańska Urszula 
Published: October 2017

AbstractSmall brachiopods of the families Craniidae Menke, 1828 and Thecidellinidae Elliott, 1958 were selected from the Oxfordian sequence which lies transgressively upon a Variscan rhyodacite laccolite exposed at Zalas in the Cracow Upland, southern Poland, a site which is well-known due to various kinds of ubiquitous fossils. The craniids include three species: Craniscus bipartitus (Münster in Goldfuss, 1837), Craniscus tripartitus (Münster in Goldfuss, 1837) and Craniscus antiquior (Jelly, 1843), and the thecidellinids - two species: Rioultina zalasensis sp. nov. and Rioultina wapiennensis Krawczyński, 2008. The species described herein indicate tropical or subtropical waters, and a moderately (?) deep character of the sea basin at Zalas.
Sevoflurane and isoflurane genotoxicity in kidney cells of mice
Authors: Brozović Gordana , Oršolić Nada , Rozgaj Ružica , Knežević Fabijan , Knežević Anica Horvat , Maričić Martina , Krsnik Dajana , Benković Vesna 
Published: October 2017

Abstract
The aim of this study was to evaluate the DNA damage and repair in kidney cells of Swiss albino mice after repeated exposure to sevoflurane and isoflurane and compare their detrimental effects. We used the alkaline comet assay to establish the genetic damage and measured three parameters: tail length, tail moment, and tail intensity of comets. These parameters were measured immediately after exposure to the above mentioned inhalation anaesthetics, two hours, six hours, and 24 hours later and were compared with the control group. Mean values of all three parameters were significantly higher in experimental groups compared to the control group. DNA damage in kidney cells of mice exposed to sevoflurane increased continuously before it reached its peak 24 hours after exposure. Isoflurane induced the highest DNA damage two hours after exposure. Levels of DNA damage recorded 24 h after cessation of exposure to both tested compounds suggest that sevoflurane was slightly more genotoxic than isoflurane to kidney cells of mice. According to these results, the currently used volatile anaesthetics sevoflurane and isoflurane are able to damage DNA in kidney cells of mice. Such findings suggest a possibility for similar outcomes in humans and that fact must be taken into account in everyday clinical practice.
The comparative context and methodology of literary history in Hanuš Jelínek’s Histoire de la littérature tchèque
Authors: Zelenka Miloš 
Published: October 2017

Abstract
The paper evaluates the importance of the French-written Histoire de la littérature tchèque I–III [The History of Czech Literature] (1930–1935) by Hanuš Jelínek (1878–1944), a leading expert and authority on French–Czech cultural relations. His synthetic work destined for French readers and completed outside the modern methodological context of the 1930s draws on Ernest Denis’ concept of Czech literary development as the ‘literature of struggle’ against the German element, while its composition is inspired by Arne Novák’s history written in German, and his expository method follows in the footsteps of his mentor Jaroslav Vlček. Therefore, Jelínek conceives literary development as a continual motion of ideas within an aesthetic form, as a subject-stratified, multi-layered story unified by the central outlook enabling him on the one hand to emphasise the nationally defensive aspect of Czech literature, and, on the other hand, to present it through parallels and illustrative examples within the European perspective. Jelínek’s Histoire, supplemented with a number of his own translations of Czech authors, is a particular narrative–historical genre – the epitome of the young Czech nation’s cultural policy and an archetype of cordial relations between the Czechoslovak and French cultures.
Václav Hladík. The Direct (and Forgotten) Predecessor of Hanuš Jelínek
Authors: Hnilica Jiří 
Published: October 2017

Abstract
The article studies the major stages in the life of the Czech journalist and writer Václav Hladík. This native of Prague died prematurely in 1913. In particular, the study tries to demonstrate his connections to another remarkable figure of cultural transfer – Hanuš Jelínek. In the first place, these included his work for the literary periodical Lumír, followed by his activities in the area of Czech-French relations. It was Hladík that introduced Jelínek to Parisian salons. The paper draws attention to personal continuity as well as a qualitative shift in Czech Francophilia at the turn of the 20th century.
Public Presentation of Non-European Cultures at the Turn of the 19th and 20th Centuries. Part 2: “From Worlds Afar” – The Lecture Activity of Enrique Stanko Vráz
Authors: Todorovová Jiřina 
Published: October 2017

Abstract
The way in which the Czech public learned about exotic countries at the end of the 19th and 20th centuries was dependent above all on the ability of travellers to convey their experience in literary form, as travelogue, or to communicate their experiences directly – in lecture form. From the 1890s lectures were accompanied by the projection of slides. One of the best-known travellers, and an excellent lecturer, was Enrique Stanko Vráz (1860–1932). The Náprstek Museum holds an extensive collection of glass slides from his estate. Vráz filled the periods in between his various world travels with intensive lecture activity, and the themes of his lectures grew wider with the increasing number of journeys he undertook. Information gained from Vráz’s lectures had a marked effect on the outlook of broad swathes of the population of the Czech lands on the life and cultures of non-European areas.
Ibn Quzmān Between Ribera, Nykl and Asín and the Newly Created Escuela de Estudios Árabes of Madrid (1932–1933)
Authors: Ženka Josef 
Published: October 2017

Abstract
In 1933, the newly founded Escuela de Estudios Árabes of Madrid printed Nykl’s edition of Dīwān Ibn Quzmān as its inaugural book. The Nykl papers held at the Náprstek Museum offer great insight into the working method of an orientalist of the first half of the 15th century. It is the aim of this article to demonstrate the author’s preparations and, through them, to analyze author’s working method, his relations to his predecessor Julián Ribera and reasons behind the final form of the book. The significant use of Nykl’s papers in the article demonstrates the importance of personal papers for mapping the writing and publishing processes.
Loudness Functions and Binaural Loudness Summation in Bilateral Cochlear Implant Users
Authors: Kordus Monika , Żera Jan 
Published: October 2017

AbstractLoudness functions and binaural loudness summation was investigated in acoustically stimulated bilaterally implanted cochlear implant users. The study was aimed at evaluating growth of loudness functions and binaural loudness summation in cochlear implant subjects as a function of stimulus presentation level at different frequencies. Loudness was assessed using a rating procedure on a scale of 0 to 100. Three experimental conditions were tested: monaural right, monaural left and binaural, each with bands of noise with center frequencies of 0.25, 1, and 4 kHz. Fifteen implanted and five normal-hearing subjects (control group) participated in the experiments. Results demonstrated large variability in the slopes of the loudness functions and the presence of loudness summation in bilateral cochlear implant users, with large individual differences among subjects.