bluuebunny/crossref_metadata_2025_split huggingface dataset:
Faktor Intention to Stay pada Karyawan dalam Lingkungan Kerja: Pendekatan Systematic Literature Review
Authors: Nurhalizah Hayyumu Farina , Rizki Sridadi Ahmad , Eliyana Anis 
Published: October 2024

This study aims to explore the factors that contribute to employee intention to stay in a work environment. The method used in this study is a systematic literature review of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) using articles from the Scopus database from 2018 to 2023. The results of the study indicate that the factors that influence employee intention to stay based on the literature review conducted by author 1 are talent development, work intensification, cultural competence, aspects (psychological, rational, and fundamental), perceived organizational factors, spirituality in the workplace, promotion, job satisfaction, stress, work frequency, training, mentoring, work environment, distributive justice, paternalistic leadership, trust in management, clarity of goals, work family conflict, rational job creation, HR practices (recruitment, training, performance appraisal, rewards, career opportunities), organizational practices, perception of calling, learning opportunities, and employee value proposition (EVP).
Keywords: Intention To Stay, Workplace, Systematic Literature Review
Illegal Marriages
Authors: Canales Nelson 
Published: October 2024

Pope Innocent III has drawn constant scholarly attention in the realm of medieval history. Not only was his papacy fundamental in the shaping of the modern-day Roman Catholic Church, but his time as Roman Pontiff is also considered the apogee of the medieval papacy. He expanded papal influence into realms previously dreamt of by Church reformers and exerted it over secular rulers. An often-contested topic of Innocent’s historiography is the motivations and justifications for his actions. Are we to view them through the lens of reform or the mind of a pragmatist? This paper contributes to this debate by analyzing Innocent’s letters and actions pertaining to the consanguineous marriages of Alfonso IX with Berenguela in the Iberian Peninsula and Otto IV with Beatrix in the German lands. By comparing the actions and justifications of Pope Innocent III in the Iberian Peninsula and the German lands—an area on the periphery of Europe and one central in it—this paper seeks to uncover, firstly, whether Innocent acted similarly in comparable situations from both areas and, secondly, whether Church reform or pragmatism influenced his arguments and measures. This paper finds that Innocent acted in a reformist manner (disregarding temporal outcomes in favor of spiritual strictness) in the Iberian Peninsula while he focused on temporal matters through a pragmatic approach in the German lands due to the severe threat the German Empire posed to Church independence and the ongoing Reconquista in Iberia. Utilizing a comparatist approach to this topic allows for conclusions to be made from his actions in different regions rather than a case study in a singular region.
Sensory Evaluation of Local Versus Imported Shrimp to Develop Marketing Strategies for United States Shrimp Producers
Authors: Gina Fimiano  , Katlyn Nau  , Charles Sims  , Razieh Farzad  
Published: October 2024

Shrimp is considered a high-value seafood product and the most consumed seafood in the Unites States. However, it is characterized by a short shelf-life. United States is heavily dependent on seafood imports, including shrimp, with more than 80 % of seafood being imported. The imported shrimp products are usually treated with preservatives such as phosphate to maintain quality, and possibly multiple rounds of freezing and thawing that can affect quality as well. Therefore, this study aimed to understand and compare the sensory/organoleptic characteristics of imported to US-based shrimp products. Additionally, nutritional values of the shrimp products were evaluated by analyzing their proximate composition. These results of the sensory panel showed a discrepancy between consumer stated preferences and actual behavior regarding shrimp products. While participants expressed a preference for preservative-free shrimp, as demonstrated acceptability was higher for imported shrimp containing preservatives. Proximate analysis showed farmed-raised shrimp to have significantly higher (p<0.05) protein content in comparison to wild–caught and imported shrimp. This can be a leverage to develop marketing strategies for locally produced shrimps that are not treated with preservatives.
Hubungan Antara Kadar Asam Urat Dengan Aktivitas Fisik Pada Lansia Di Wilayah Kerja Puskesmas Mulyorejo Kota Malang
Authors: Purukan Anisya Setya Anggriani , Rahmanto Safun , Lubis Zidni Imanurrohmah 
Published: October 2024

Lanjut usia rentan terhadap penurunan berbagai tingkat kesehatan, terutama tingkat kesehatan fisik, dan penurunan kesehatan yang disebabkan oleh penuaan yang mempengaruhi kualitas hidup mereka. Seiring bertambahnya usia, berbagai penyakit muncul, kemampuan tubuh dan keseimbangan menurun, dan kemungkinan terjatuh meningkat. Asam urat merupakan penyakit degeneratif yang mempengaruhi sendi dan menyebabkan pembengkakan, peradangan, dan nyeri pada bagian sendi, yang membuat aktivitas fisik menjadi sulit. Menggunakan desain penelitian observasional analitik dan desain cross-sectional. Sebanyak 44 orang lanjut usia diambil sebagai sampel dalam penelitian ini, yang dilakukan di wilayah kerja Puskesmas Mulyorejo Kota Malang, dengan menggunakan metode purposive sampling. Alat yang digunakan adalah survei Global Physical Activity Questionaire. Dengan menggunakan aplikasi SPSS, tes statistik Spearman’s Rho digunakan untuk menganalisis data. Hasil: Hasilnya menunjukkan bahwa ada hubungan yang signifikan antara kadar asam urat dan aktivitas fisik pada lansia di wilayah kerja Puskesmas Mulyorejo. Berdasarkan hasil didapatkan H1 diterima, yaitu, Ada hubungan antara kadar Asam Urat dengan Aktivitas Fisik dan H0 ditolak menurut hasil analisis statistik dengan nilai sig 0,023 (p < 0,05). Studi yang dilakukan di Wilayah Kerja Puskesmas Mulyorejo menunjukkan bahwa terdapat korelasi signifikan antara tingkat asam urat yang tinggi dan aktivitas fisik pada lansia.
Pengaruh Senam Hamil Dalam Mengurangi Nyeri Punggung Bawah Pada Ibu Hamil Trimester Ketiga Di Puskesmas Sidorejo Lampung Timur
Authors: Juita Kadek Endang , Puspita Richta , Lestari Yuli 
Published: October 2024

Nyeri punggung bawah ibu hamil pada trimester ketiga. Nyeri punggung menimbulkan dampak negatif pada kualitas hidup seperti kebugaran fisik, ketenangan psikologis, tingkat kemandirian, hubungan sosial, hubungan dengan lingkungan, dan kondisi spiritual yang dikarenakan terganggunya aktifitas fisik sehari-hari, bebagai gangguan yang dapat menghambat aktivitas ibu hamil, seperti gangguan motorik, insomnia, dan depresi. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh senam hamil dalam mengurangi nyeri punggung bawah pada ibu hamil trimester ketiga di Puskesmas Sidorejo Lampung Timur. Desain One Group Pretest-Postest. Populasi seluruh ibu hamil dengan sampel 30. Alat ukur menggunakan Skala nyeri Numerical Rating Scale (NRS). Uji statistik menggunakan Wilcoxon. Hasil nilai rata-rata nyeri punggung sebelum diberikan senam hamil adalah 3,90, stelah diberikan senam hamil rata-rata nyeri punggung menurun dengan selisih 2,67. Hasil uji Wilcoxon Signed Ranks Test menunjukkan nilai p-value sebesar 0,000 (<0,05). Kesimpulan senam hamil terbukti mampu menurunkan nyeri pinggang ibu hamil.
PENGARUH EDUKASI KESEHATAN IBU HAMIL TERHADAP GEJALA ANEMIA
Authors: Dari Wulan , Widyaningsih Dian Palupi , Cahyani Anita Dian , Utami Ita Resti , T Marlina , Nurhalimah Nurhalimah , Nurlina Nurlina 
Published: October 2024

Ibu hamil, sebagai kelompok yang rentan terhadap berbagai isu kesehatan, seringkali menghadapi tantangan, termasuk masalah umum seperti anemia. Anemia pada ibu hamil merupakan masalah kesehatan yang signifikan dengan dampak potensial terhadap kesejahteraan ibu dan janin. Penelitian ini dilakukan dengan tujuan untuk mengevaluasi pengaruh edukasi kesehatan terhadap pengetahuan ibu hamil mengenai gejala anemia. Metode penelitian yang digunakan adalah desain pra eksperimental dengan pendekatan One group pra posttest design. Data dikumpulkan melalui kuesioner yang dirancang untuk menilai pengetahuan ibu hamil tentang anemia dan gejala yang terkait. Setelahnya, dilakukan sesi penyuluhan sebagai bentuk edukasi kesehatan. Analisis menggunakan uji N-gain ternormalisasi. Temuan penelitian ini menggambarkan bahwa penerapan uji N-gain ternormalisasi pada kuesioner pretest dan posttest memberikan gambaran yang komprehensif mengenai peningkatan pengetahuan ibu hamil terhadap gejala anemia setelah menerima sesi penyuluhan.
Teachers’ Quality and Students’ Academic Performance in Osun State Public Senior Secondary Schools, Nigeria
Authors: Shittu Afeez Adeshina 
Published: October 2024

Effective and efficient quality of teachers improves the level of students’ academic performance. This study investigated teachers’ quality and students’ academic performance in Osun State Public Senior Secondary Schools, Nigeria. The objectives of this study were to establish the relationship between teachers’ academic qualifications; teachers’ years of teaching experience; teachers’ professional qualifications and teachers’ exposure to in-service training and students’ academic performance in Osun State Public Senior Secondary Schools. The study adopted a descriptive survey of correlational type. Three hundred respondents were used for the study. Teachers’ Quality Questionnaire” (TQQ) and Students’ Academic Performance Proforma (SAPP) were used for data collection. Five research questions were raised and answered to guide the study's conduct using descriptive statistics of frequency and percentages. Five research hypotheses were formulated and tested using inferential Pearson Product-Moment correlation statistics at 0.05 significance level. Findings showed that teachers’ quality has a positive and significant relationship with students’ academic performance in Osun State Public Secondary Schools, Nigeria. Based on the findings, it was recommended among others that; school management should ensure that teachers yet to register as professionals should be encouraged to do so. This will enable teachers to register with the Teacher Registration Council of Nigeria (TRCN) and be identified as qualified teachers also endeavours to motivate teachers to attend educational conferences to improve their teaching skills to be effective and efficient.
Psychological Impact of Covid-19 Pandemic on Health Care Workers of a Field Hospital in UN Peacekeeping Mission
Authors: Dewan Mohammed Akhter Hasib , Mahboob Sabiha , Haque Md Ariful , Huda Md Faisal 
Published: October 2024

Background: The Covid-19 pandemic has significantly affected the healthcare system worldwide as well as the psychological state of all. The objective of the current study was to assess the psychological conditions of the healthcare workers in Enhanced Level 1+ Hospital, Bouar, Central African Republic (CAR). This assessment can help in the guideline development and implication psychological interventions which in turn can improve the quality of life, working environment and decision-making capabilities of health care workers during widespread pandemic.
Methods: This descriptive cross-sectional study was conducted on 40 medical personnel working in Enhanced Level 1+ Hospital, Bouar, Central African Republic. The study was performed from June 2022 to August 2022. Assessment of psychological status of military healthcare providers was done by analyzing the results derived from the Mental health survey, Perceived Stress Scale (PSS-10), Generalized Anxiety Disorder scale (GAD-7) and Patient Health Questionnaire (PHQ-9). Hospital records were analyzed to assess the changes in workload.
Results: The working hour increased significantly from Pre Covid to Post Covid period (1920±34.1 hours/week to 2120±67.3 hours/week) although the number of weekly patients in OPD and Emergency decreased slightly from 51.9 to 40.6. Elevated mental stress was observed during outbreak (average PSS-10 score in June 22 was 20.4 which reduced to 9.7 in August). The same pattern was observed in case of GAD-7 score (15.6 to 10.8) and PHQ-9 score (12.4 to 6.1). The percentage of concerns regarding Covid19 was high during the outbreak, 37/40 (92.5%), which decreased after wards to 18/40 (45%).
Conclusion: The UN field hospitals are inadequate to support mass outbreak like COVID 19 in the context of both staff and medical supplies. During Covid 19 outbreak, sharp rise of workload and difficulties in restocking of essential medical items played a vital role in the mental state of the medical professionals. The field hospitals in UN peacekeeping missions require intensive effort especially on disaster and epidemic management during pre-deployment training. Moreover, reconsidering distribution of human resources in field hospitals is also required.
Bangladesh Armed Forces Med J Vol 57 No (1) June 2024, pp 35-42
Explore the expression of mitochondria-related genes to construct prognostic risk model for ovarian cancer and validate it, so as to provide optimized treatment for ovarian cancer
Authors: Yunyun Zheng , Guihu Wang , An Jiang 
Published: October 2024

BackgroundThe use of gene development data from public database has become a new starting point to explore mitochondrial related gene expression and construct a prognostic prediction model of ovarian cancer.MethodsData were obtained from the TCGA and ICGC databases, and the intersection with mitochondrial genes was used to obtain the differentially expressed genes. q-PCR, Cox proportional risk regression, minimal absolute contraction and selection operator regression analysis were performed to construct the prognostic risk model, and ROC curve was used to evaluate the model for centralized verification. The association between risk scores and clinical features, tumor mutation load, immune cell infiltration, macrophage activation analysis, immunotherapy, and chemosensitivity was further evaluated.ResultsA prognostic risk score model for ovarian cancer patients was constructed based on 12 differentially expressed genes. The score was highly correlated with ovarian cancer macrophage infiltration and was a good predictor of the response to immunotherapy. M1 and M2 macrophages in the ovarian tissue in the OV group were significantly activated, providing a reference for the study of the polarity change of tumor-related macrophages for the prognosis and treatment of ovarian cancer. In terms of drug sensitivity, the high-risk group was more sensitive to vinblastine, Acetalax, VX-11e, and PD-0325901, while the low-risk group was more sensitive to Sabutoclax, SB-505124, cisplatin, and erlotinib.ConclusionThe prognostic risk model of ovarian cancer associated to mitochondrial genes built on the basis of public database better evaluated the prognosis of ovarian cancer patients and guided individual treatment.
The impact of immune dysregulation on the risk of malignancy in common variable immunodeficiency: insights from a multicenter study
Authors: Cabañero-Navalon Marta Dafne , Garcia-Bustos Victor , Balastegui-Martin Héctor , Bracke Carmen , Mateu Lourdes , Solanich Xavier , Carrillo-Linares Juan Luis , Robles-Marhuenda Angel , Puchades Francesc , Pelaez Ballesta Ana , Lopez-Osle Nuria , Torralba-Cabeza Miguel Ángel , Bielsa Masdeu Ana María , Gil Niño Jorge , Tornador Gaya Nuria , Castellanos Guillem Pascual , Sánchez-Martínez Rosario , Barragán-Casas José Manuel , González-García Andrés , Patier de la Peña José Luis , López-Wolf Daniel , Rufete Antonia Mora , Canovas Mora Alba , Moral Moral Pedro 
Published: October 2024

BackgroundCommon Variable Immunodeficiency (CVID) represents a heterogenic group of primary immunodeficiencies (PID) characterized by impaired antibody production and susceptibility to infections. Non-infectious complications, such as autoimmune diseases, lymphoproliferative disorders, and malignancies, now significantly impact prognosis. Moreover, both hematologic and solid organ malignancies are more frequently observed in CVID patients compared to other PIDs. The risk factors for carcinogenesis in CVID remain largely unknown.ObjectiveThis multicenter study aims to characterize the clinical profile of cancer in CVID patients in Spain and to identify independent risk factors associated with malignancy development, focusing on the role of immune dysregulation.MethodsA nationwide, cross-sectional study was conducted from November 2019 to May 2022, involving 17 hospitals treating PID patients in Spain. Data were collected systematically on demographics, infectious and non-infectious comorbidities, immunological parameters, and treatment. Statistical analysis, including multivariate logistic regression, was performed to identify risk factors associated to malignancy.ResultsOf 250 CVID patients, 38 (15.26%) were diagnosed with cancer, predominantly non-Hodgkin lymphoma, gastric cancer, and lung adenocarcinoma. Cancer patients were significantly older (mean age 60.70 vs. 49.36 years, p&lt;0.001) and had higher rates of immune dysregulation (81.58% vs. 59.7%, p=0.01). Immune dysregulation was an independent risk factor for cancer (OR 2.19, p=0.04), alongside previous immunosuppressant therapy (OR 2, p=0.031), higher IgM levels (OR 1.008 per SD, p=0.012), older age (OR 1.04, p&lt;0.001), and lower CD4 cell counts at diagnosis (OR 0.997, p&lt;0.001).ConclusionsThis study highlights the increased cancer risk in CVID patients, with immune dysregulation, prior immunosuppressant use, elevated IgM levels, and lower CD4 cell counts as conjointly associated. These findings underscore the need for vigilant cancer screening and tailored management strategies in CVID patients to improve outcomes. Future research should focus on elucidating the molecular mechanisms linking immune dysregulation and malignancy in CVID.
Impact of combinatorial immunotherapies in breast cancer: a systematic review and meta-analysis
Authors: Sisodiya Sandeep , Kasherwal Vishakha , Rani Jyoti , Mishra Neetu , Kumar Sandeep , Khan Asiya , Aftab Mehreen , Shagufta  , Singh Payal , Gupta Ekta , Tanwar Pranay , Hussain Showket 
Published: October 2024

BackgroundBreast cancer has the highest mortality rate among all cancers affecting females worldwide. Several new effective therapeutic strategies are being developed to minimize the number of breast cancer-related deaths and improve the quality of life of breast cancer patients. However, resistance to conventional therapies in breast cancer patients remains a challenge which could be due to several reasons, including changes in the tumor microenvironment. Attention is being diverted towards minimizing the resistance, toxicity, and improving the affordability of therapeutics for better breast cancer management. This includes personalized medicine, target-specific drug delivery systems, combinational therapies and artificial intelligence based screening and disease prediction. Nowadays, researchers and clinicians are also exploring the use of combinatorial immunotherapies in breast cancer patients, which have shown encouraging results in terms of improved survival outcomes. This study attempts to analyze the role of combinational immunotherapies in breast cancer patients, and offer insights into their effectiveness in breast cancer management.MethodologyWe conducted a systematic review and meta-analysis for which we selected the randomized clinical trials (RCTs) focused on completed Phase I/II/III/IV clinical trials investigating combination immunotherapies for breast cancer. The analysis aimed to assess the efficacy of combination therapies in comparison to mono-therapies, focusing on overall survival (OS), and progression-free survival (PFS).ResultsWe observed that, combination immunotherapies significantly (P&lt;0.05) improved OS as compared to single-drug therapies in the Phase I with overall Risk ratio (RR) of 16.17 (CI 2.23,117.50), Phase II with an overall RR of 19.19 (CI 11.76,31.30) and for phase III overall RR 22.27 (CI 13.60,36.37). In the case of PFS, it was significant with RR: 12.35 (CI 2.14, 71.26) in Phase I RR 6.10 (CI 4.31, 8.64) in phase II, RR 8.95 (CI 6.09, 13.16) in phase III and RR 14.82 (CI 6.49, 33.82) in Phase IV of clinical trials.ConclusionThe observed improvements in overall survival and progression-free survival suggest that combination immunotherapies could serve as a better approach to breast cancer management.
The effects of pulsed electromagnetic field therapy on muscle strength and pain in patients with end-stage knee osteoarthritis: a randomized controlled trial
Authors: Wang Qian-wen , Ong Michael Tim-yun , Man Gene Chi-wai , Franco-Obregón Alfredo , Choi Ben Chi-yin , Lui Pauline Po-yee , Fong Daniel T. P. , Qiu Ji-hong , He Xin , Ng Jonathan Patrick , Yung Patrick Shu-hang 
Published: October 2024

BackgroundOsteoarthritis (OA) of the knee is one of the most common chronic degenerative joint conditions affecting aging population.AimTo investigate the effectiveness of a combination of home-based exercise and pulsed electromagnetic field (PEMF) therapy to improve muscle strength, physical function, and pain.MethodsSixty patients were randomly assigned to either home-based exercise alone (control group; n = 30) or combined with PEMF therapy (treatment group; n = 30) twice a week for eight weeks. Knee extension, flexion muscle strength, gait speed (GS), 5 time sit-to-stand test (5STS), Visual Analogue Scale (VAS) pain and Knee Injury and Osteoarthritis Outcome Score (KOOS) were recorded at baseline and 4 and 8 weeks.ResultsSignificant improvements in symptomatic knee extension muscle strength (SKE, p = 0.001), flexion strength (SKF, p = 0.011), contralateral knee extension muscle strength (CKE, p = 0.002), and flexion strength (CKF, p = 0.009) were observed for the PEMF treatment group at 8 weeks. Significant reductions in VAS pain scores were observed in both the treatment (p &lt; 0.001, partial η2 = 0.505) and control (p &lt; 0.001, partial η2 = 0.268) groups. Significant differences were reported between groups in the 4 (p = 0.010, partial η2 = 0.111) and 8 (p = 0.046, partial η2 = 0.068) week assessment in VAS pain. A significant time difference was found in GS and 5STS between baseline and week 8 (GS: difference 0.051, p = 0.026; 5STS: difference 2.327, p &lt; 0.001) in the treatment group. The significant group difference at week 8 was observed in SKE (p = 0.013) in female patients while pain in male patients (p = 0.026). Patients aged over 70 years have a significantly superior improvement in SKE, SKF, and CKF after 8 weeks of PEMF therapy.ConclusionThe combination of PEMF therapy and home-based exercise superiorly improved knee muscle strength and reduced pain in end-stage knee OA subjects and showed a promising tendency to improve performance-based physical function. PEMF therapy was shown to preferentially benefit knee muscle strength in female patients and patients aged over 70 years, whereas male patients were more responsive to PEMF therapy in the form of pain relief.Clinical trial registrationclinicalTrials.gov, NCT05550428.