bluuebunny/crossref_metadata_2025_split huggingface dataset:
A systematic review of immersive educational technologies in medical physics and radiation physics
Authors: Tene Talia , Bonilla García Nataly , Coello-Fiallos Diana , Borja Myrian , Vacacela Gomez Cristian 
Published: October 2024

ObjectiveThis systematic review aims to analyze and synthesize the current state of research on the role of immersive technologies, specifically augmented reality (AR), virtual reality (VR), and mixed reality (MR), in medical physics and radiation physics education. The primary focus is to evaluate their impact on learning outcomes, performance, and engagement across various educational contexts.MethodsWe conduct a comprehensive search of four major databases: Scopus, Web of Science, PubMed, and IEEE Xplore, covering the period from 2012 to 2023. A total of 316 articles are initially identified. After removing duplicates and screening for relevance based on titles and abstracts, 107 articles are selected for full-text review. Finally, 37 articles met the inclusion criteria and are included in the analysis. The review follows the PRISMA guidelines and utilizes the PICOS framework to structure the research question.AnalysisData extraction focuses on key variables such as the type of immersive technology used, educational context, study design, participant demographics, and measured outcomes. The studies are analyzed for their reported effects on learning outcomes, performance, and engagement.ResultsThe review found that immersive technologies significantly enhance learning outcomes and engagement. Specifically, 36.4% of the studies reported increased engagement, while 63.6% of studies focusing on practical skills noted performance improvements. The use of AR, VR, and MR showed broad applicability across different educational levels, from undergraduate courses to professional training programs.ConclusionImmersive technologies have considerable potential to transform medical and radiation physics. They enhance student engagement, improve learning outcomes, and boost performance in practical skills. Nevertheless, future research should focus on standardizing methodologies, expanding participant demographics, and exploring long-term impacts on skill retention and clinical practice. This review provides a valuable resource for guiding future research and implementing innovative educational strategies in the dynamic fields of medical physics and radiation physics.
Research status and development trends of omics in neuroblastoma a bibliometric and visualization analysis
Authors: Han Mengliang , Niu Huizhong , Duan Fei , Wang Zhaolong , Zhang Zhiguang , Ren Hui 
Published: October 2024

BackgroundNeuroblastoma (NB), a prevalent extracranial solid tumor in children, stems from the neural crest. Omics technologies are extensively employed in NB, and We analyzed published articles on NB omics to understand the research trends and hot topics in NB omics.MethodWe collected all articles related to NB omics published from 2005 to 2023 from the Web of Science Core Collection database. Subsequently, we conducted analyses using VOSviewer, CiteSpace, Bibliometrix, and the Bibliometric online analysis platform (https://bibliometric.com/).ResultsWe included a total of 514 articles in our analysis. The increasing number of publications in this field since 2020 indicates growing attention to NB omics, gradually entering a mature development stage. These articles span 50 countries and 1,000 institutions, involving 3,669 authors and 292 journals. The United States has the highest publication output and collaboration with other countries, with Germany being the most frequent collaborator. Capital Medical University and the German Cancer Research Center are the institutions with the highest publication count. The Journal of Proteome Research and the Journal of Biological Chemistry are the most prolific journal and most co-cited journal, respectively. Wang, W, and Maris, JM are the scholars with the highest publication count and co-citations in this field. “Neuroblastoma” and “Expression” are the most frequent keywords, while “classification,” “Metabolism,” “Cancer,” and “Diagnosis” are recent key terms. The article titled “Neuroblastoma” by John M. Maris is the most cited reference in this analysis.ConclusionThe continuous growth in NB omics research underscores its increasing significance in the scientific community. Omics technologies have facilitated the identification of potential biomarkers, advancements in personalized medicine, and the development of novel therapeutic strategies. Despite these advancements, the field faces significant challenges, including tumor heterogeneity, data standardization issues, and the translation of research findings into clinical practice.
IGF1R inhibition and PD-1 blockade improve anti-tumor immune response in epithelial ovarian cancer
Authors: Somri-Gannam Lina , Meisel-Sharon Shilhav , Hantisteanu Shay , Bar-Noy Tomer , Sigal Emiliya , Groisman Gabriel , Hallak Mordechai , Werner Haim , Bruchim Ilan 
Published: October 2024

IntroductionThe insulin-like growth factor (IGF) system plays a key role in regulating growth and invasiveness in epithelial ovarian cancer (EOC) and is considered a promising therapeutic target. EOC is an immunosuppressive disease, although there are limited data about the involvement of the IGF1R system in the anti-tumor immune response in the EOC microenvironment.MethodsIn the current study, we hypothesized that IGF 1 receptor (IGF1R) involvement in the maturation of dendritic cells (DC) with the co-inhibition of IGF1R and PD-1 would affect the EOC microenvironment.ResultsWe found that DC pretreated with IGF1R inhibitor resulted in fewer EOC cells. Moreover, in vivo experiments conducted with an EOC mouse model, with anti-PD-1/IGF1R combined, resulted in lower tumor weight compared to individual treatments. Additionally, anti-PD-1/IGF1R treatment increased DC by 34% compared with AEW-541 and 40% with anti-PD-1. The combined treatment increased CD8+ T-cell levels compared to AEW-541 alone. RNA-seq data analysis indicated that anti-PD-1/IGF1R led to a more potent immune response, as reflected by altered gene expression levels related to anti-tumor immune response, compared with either treatment alone.DiscussionThese findings provide novel evidence that IGF1R axis inhibition combined with PD-1 blockade may be an effective therapeutic strategy for selected EOC patient populations.
Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model
Authors: Ghimire Hemendra , Sargur Madabushi Srideshikan , Vercellino Justin , Brooks Jamison , Zuro Darren , Lim Ji Eun , Vishwasrao Paresh , Abdelhamid Amr Mohamed Hamed , Strome Guy , Eichenbaum Gary , Al Malki Monzr , Guha Chandan , Hui Susanta K. 
Published: October 2024

BackgroundThere is a need for therapies that can mitigate bone marrow dysfunction and organ toxicity that occur following myeloablative injury and reduced intensity conditioning regimens used in patients undergoing bone marrow transplantation (BMT). The pathogenesis of adverse effects from BMT conditioning has been linked to injury to the vascular endothelium, bone marrow (BM), and other organs.ObjectiveTo evaluate the impact of the thrombopoietin mimetic drug JNJ-26366821 (TPOm) on BM vascular recovery in mice undergoing myeloablative radiation conditioning followed by BMT.Study designTPOm (doses: 0 µg, 300 µg, 1000 µg per Kg body weight) was administered on Days 0 and 7 after BMT, in mice receiving a total body irradiation (TBI) conditioning regimen (5.5 Gy x 2) before congenic BMT. BM donner cell engraftment was analyzed using flow cytometry on Days 7, 14, and 30 post-BMT. The morphological and biophysical properties of the BM vasculature were evaluated by intravital multiphoton microscopy (MPM) and immunofluorescence confocal imaging. Herein, morphological properties involve microvascular density (MVD), vessel diameter, and vascular area, while biophysical properties include transfer rate (Ktrans) of contrast within the BM vascular niche, as well as the fractional volume (vec) of extracellular extravascular tissue (EES).ResultsNo significant difference in donor chimerism was observed at days 7, 14, and 30 post-BMT, between TPOm and PBS-treated mice. TPOm intervention improved BM vasculature regeneration in transplanted mice. The MVD, Ktrans, and BM vasculature as well as vascular endothelial growth factor receptor-2 (VEGFR2) in the BM, showed a dose dependent improvement in mice treated with TPOm. On day 14 post-BMT, the group receiving 1000 µg/Kg TPOm showed significant shifts (p-value &lt; 0.05) in MVD, Ktrans, and VEGFR2 expression from their corresponding control types (TPOm dose 0 µg) towards levels comparable to healthy controls.ConclusionTPOm intervention augments BM vascular structure and function, which may be important for hematopoietic recovery and bone marrow function in radiation conditioned hematopoietic stem cell transplant patients, in addition to enhancing platelet recovery.
Perceived feedback and school belonging: the mediating role of subjective well-being
Authors: Li Xinyu , Kuo Yi-Lung , Huggins Thomas J. 
Published: October 2024

IntroductionThis study examined the interplay between perceived feedback (PF), subjective wellbeing (SWB), and students’ sense of belonging to school (SBS). School belonging is a key factor for decisions regarding academic studies, and is usually impacted by PF. The current study explored whether SWB mediates the established relationship between PF and SBS.MethodThis was achieved by applying a mediation model to PISA 2018 data from 12,058 students in four areas of China.ResultsPerceived feedback positively affected students’ SBS (β = 0.26, p &lt; 0.01); and that SWB partially mediated this relationship between PF and SBS (β = 0.47, p &lt; 0.01).DiscussionThe findings of this study have the potential to contribute to the existing literature on educational psychology and well-being. By shedding light on the mediating role of SWB, the research offers practical implications for educators and policymakers seeking to enhance students’ school belonging and other implications for their academic success. Further research can contribute to this promising area, by focusing on subjective wellbeing and its impact on a range of decisions being made by students during a critical phase of their personal and academic development.
“And I Can Remind Myself That I Am All Of This”: adolescents’ experiences of group-based acceptance and commitment therapy
Authors: Brovold Filippa , Laugen Nina Jakhelln , Grøtte Torun 
Published: October 2024

IntroductionA growing body of literature supports the use of Acceptance-and commitment therapy (ACT) for a wide range of mental health problems in children and adolescents, but less is known about ACT when given to adolescents in a group format. Consequently, this study aimed to explore the subjective experiences of adolescents who had completed a group-based ACT for symptoms of anxiety and depression. Adolescents’ perceptions of the core therapeutic processes of ACT and the means used to enhance them, as well as the interplay between ACT processes and the group format, were of primary interest.MethodsSemi-structured qualitative interviews were conducted with seven adolescents, of which five were girls and two were boys, between 16 and 19 years old. Transcripts were analyzed using reflexive thematic analysis.ResultsThe adolescents varied greatly in their experience of ACT’s core processes and the methods used to enhance them. Most found the core processes meaningful and educational, especially appreciating the concept of values and value-based action. However, some perceived the core processes as irrelevant and provocative, particularly interpreting acceptance as “giving up.” The metaphors and practical exercises were experiences as playful and instructive supplements to the more theoretical elements of therapy, but also as childish and embarrassing. The group format facilitated normalization and support and seemed to increase the adolescents’ motivation and adherence to therapeutical work, but it also triggered socially anxious thoughts and self-censoring for some.ConclusionThe results from the current study support previous literature indicating that group-based ACT is an acceptable and feasible treatment format for adolescents. Yet, the varying experiences underscores the need for further studies exploring how to accommodate the group format to the diverse personal and developmental disparities in this age group. Randomized controlled trials are also needed to compare the effectiveness of individual versus group format of ACT for adolescents.
Realising agency: insights from participatory research with learners in a South African sexual and reproductive health programme
Authors: Coakley Chelsea , Lee Devyn , Pike Carey , Myers Laura , Hartmann Miriam , Oduro Asantewa , Ntlapo Noluthando , Bekker Linda-Gail ,   Youth Investigators of the Goals for Girls study
Published: October 2024

BackgroundInvesting in the capabilities of adolescents is essential to achieving the United Nations Sustainable Development Goals, which focus on realising adolescent girls and young women’s (AGYW) rights to education, health, bodily autonomy and integrity, sexual and reproductive health (SRH) and well-being. Despite significant scientific and programmatic progress in understanding and responding to their unique and intersecting vulnerabilities, AGYW continue to face disproportionate risk of STIs, HIV and early pregnancy. Health promotion and preventative interventions stand to be improved by early and meaningful engagement of AGYW in intervention design and delivery.MethodsThis study employed Youth Participatory Action Research (YPAR) to co-generate lessons for future school-based SRH programming. The 5-step YPAR process included: (1) youth investigator recruitment; (2) youth investigator training and co-design of YPAR methods; (3) youth investigator-led data collection; (4) collaborative analysis and interpretation; and (5) dissemination.ResultsCollaborative analysis revealed improvements in self-concept and bodily autonomy, understanding and formation of healthy relationships and demand for girl-centred health services and information at school. Additionally, the study highlights YPAR’s positive influence on both the collaborative process and outputs of research. Further, it provides further insight into the quantitative biomedical and socio-behavioural findings of a larger experimental impact evaluation, in which it was nested.ConclusionResults from YPAR methods point to high programme acceptability and practical lessons to inform future school-based SRH programming. The inclusion of adolescent girls in the design, delivery and evaluation of intervention research that affects their lives is an important strategy for improving acceptability, and also has demonstrated value in building their health and social assets. Future recommendations include parental involvement, and employing quantitative measures for better evaluation of youth engagement, leadership and partnerships in the research process.
Uncovering the determinants of health in deprived urban neighborhoods in Accra, Ghana: a qualitative and participatory reconnaissance study
Authors: Amedzro Nina , Anaseba Dominic , Darkwa Akosua Gyasi , Twumasi Afua , Ayim Andrews , Ansah-Ofei Adelaide Maria , Dovlo Delanyo , Awoonor-Williams John K. , Agongo Erasmus Emmanuel Akurugu , Agyepong Irene Akua , Elsey Helen 
Published: October 2024

BackgroundDelivering primary care services within the context of rapid urbanization and a changing disease burden is a major challenge in sub-Saharan Africa. Rural models of primary care, including the “Community-based Health Planning and Services” (CHPS) programme in Ghana, have shown improved health outcomes. However, adapting these to the urban context has proved problematic. Differences in the determinants of health found in these settings may help to explain the challenges of delivering CHPS in poor urban neighborhoods in Accra. To inform the redesign of CHPS for the urban context, we aimed to understand the determinants driving health and engagement with health services in three informal settlements in Accra.MethodsThis study formed a reconnaissance phase for a subsequent participatory action research study. We used qualitative and participatory methods to explore the influence of wider and proximal determinants on health and the use and perceptions of CHPS. Three transect walks with community leaders across the study settings informed interview guides and the recruitment of suitable participants for key informant and focus group interviews. Using a Framework Approach, we analysed transcripts and reports from these activities and developed themes and sub-themes in participants’ experiences accessing healthcare.ResultsOur findings highlight the importance of wider and proximal determinants of health including physical environment, gender and other social stratifiers including age, ethnicity, religion and disability, on health, health seeking behavior and personal behaviors such as substance misuse, tobacco use and alcohol. Utilization of CHPS was low and seen primarily as a service for maternal and child health. Private providers, ranging from informal drug stores to private clinics, were used most commonly. Community leaders and groups were active, but engagement was limited by opportunity costs for members.ConclusionTraditional service delivery packages need to be adapted to include non-communicable diseases driven by risk behaviors such as tobacco, unhealthy diet, alcohol and substance abuse. Assets such as volunteerism and nurses embedded within communities are challenging to attain in complex urban settings, yet other assets exist including occupational associations and a range of informal and private providers that could support delivery of preventive and promotive health care with equitable reach.
Forecasting air passenger traffic and market share using deep neural networks with multiple inputs and outputs
Authors: Jafari Nahid , Lewison Martin 
Published: October 2024

IntroductionIn this study, we address the challenge of accurate time series forecasting of air passenger demand using historical market demand data from the U.S. commercial aviation industry in the 21st century. Commercial aviation is a major contributor to the U.S. economy, directly or indirectly generating ~US$1.37 trillion annually, or 5% of annual GDP, and supporting more than 10 million jobs (Airlines for America, 2024). Over 1 billion passengers flew through U.S. airports in 2023 (Bureau of Transportation Statistics, 2024a). Using multiple correlated time series inputs predicts future values of multiple interrelated time series and leverages their mutual dependencies to enhance accuracy.MethodsIn this study, we introduce a two-stage algorithm employing a deep neural network for correlated time series forecasting, addressing scenarios where multiple input variables are interrelated. This approach is designed to capture the influence that one time series can exert on another, thereby enhancing prediction accuracy by leveraging these interdependencies. In the first stage, we fit four Recurrent Neural Network (RNN) models to generate accurate univariate forecasts, each functioning as a single input-output model to predict aggregated market demand. The Gated Recurrent Unit (GRU) model was the top performer for our dataset overall. In the second stage, we apply the best fitted model (GRU Model) from Stage 1 to each individual competitor (disaggregated from the market) and then merge all input tensors using the Concatenate function.Results and discussionWe hope to contribute to the relevant body of knowledge with a deep neural network framework for forecasting market share among competitors in the U.S. commercial aviation industry, as no similar approach has been documented in the literature. Given the importance of the industry, there is potentially great value in applying sophisticated forecasting techniques to achieve accurate predictions of air passenger demand. Moreover, these techniques may have wider applications and can potentially be employed in other contexts.
Developing small satellite ground support software for orbit tracking and target acquisition of the HARP cubesat
Authors: Sienkiewicz Noah , Martins J. Vanderlei , Xu Xiaoguang , McBride Brent A. , Remer Lorraine A. 
Published: October 2024

Small satellites are efficient at performing Earth science from space due to their limited cost and size. Small satellites (cubesats) achieve much with limited power production/storage, heat dissipation, data storage, and ground contact points/bandwidth. As such it is beneficial to offload as much as possible to ground support systems. Consider the HyperAngular Rainbow Polarimeter (HARP) Cubesat. Its goals were to serve as a technical demonstration prior to the development of HARP2 aboard the NASA Plankton Aerosol Cloud and ocean Ecosystem (PACE) mission and to serve as an Earth viewing remote sensing platform which measured the characteristics of clouds and aerosols. HARP cubesat was limited to taking 5-minute capture sequences once every 24 h. It took approximately 10 such captures before it needed to perform data downlink and have its memory cleared for continued use. A ground station at NASA Wallops supported HARP with approximately three points of contact each day. To maximize the value of each capture, ground support software was developed leveraging public data to inform the schedule of each capture. In this paper, we review the algorithms and data sources that allowed us to: 1; predict the HARP orbital track a week in advance, 2; predict also the location of other remote sensing satellites and ground stations relative to HARP, 3; predict the ground view geometry of the instrument along its orbital track, 4; compare global climatological data products of clouds and aerosols along the predicted orbital tracks, and 5; identify and integrate important ground target locations based on remote sensing literature and ongoing natural phenomena. This HARP Orbital Prediction System (HOPS) made HARP into a successful technical demonstration which also offered significant science value. The HOPS system presents a valuable methodology for small satellites to operate efficiently despite their limited capabilities. HOPS is also a useful testbed for studying the sensitivity of scene geometry. Using HOPS, we show that for a wide field-of-view (FOV) instrument, like HARP, latitude/longitude geolocation varies by approximately 0.1∘ at a height of 8–10 km. Scattering angles vary less than 0.01∘ at similar heights, with the worst performance near direct backscatter 180∘.