bluuebunny/crossref_metadata_2025_split huggingface dataset:
Circadian fruit phenology: An overlooked crucial aspect of plant‐frugivore interactions
Authors: Garrote P. J. , Morera B. , Costales M. , Fedriani J. M. 
Published: October 2024

Abstract

The intrinsic ability of plants to face environmental diel changes is paramount for flowering and interactions with pollinators and herbivores. Surprisingly, despite the commendable research efforts on the ecology and evolution of fruit‐frugivore interactions, very little is known about how fruit ripening and dropping vary throughout 24‐h cycle. Even less is known about the potential consequences of circadian fruit phenology on plant interactions with mutualistic and antagonistic frugivores.

We illustrate for the first time how the circadian pattern of fleshy fruit dropping and its matching/mismatching with the diel activity of functionally diverse frugivores (fruit/seed predators, seed dispersers, pulp feeders) can drive the outcome of complex multispecies plant‐frugivore interactions.

To that end, we used camera trapping to quantify the circadian fruit dropping of a mammal‐dispersed tree, Pyrus bourgaeana, and the diel activity patterns of its functionally diverse vertebrate frugivores during two fruiting seasons in two tree populations of Mediterranean Spain. Using a large data set (20,878 frugivore visits and 701 fruit‐dropping records), we evaluate the adaptive hypothesis that the circadian pattern of fruit dropping will match the diel activity of seed dispersers rather than that of fruit/seed predators.

Fruit dropping during daytime doubled that at night‐time, being considerably consistent across and within seasons, study sites and individual trees. Specifically, overlaps between circadian patterns of fruit dropping across and within seasons (0.83 and 0.84 ± 0.02, respectively), study sites (0.95) and individual trees (0.68 ± 0.01) were always high. Whereas seed dispersers (mammalian carnivores) were mostly nocturnal, the most frequent fruit/seed predators (cervids) were mostly diurnal. Consequently, and contrary to our expectations, circadian fruit dropping was more aligned with the diel activity of overabundant fruit/seed predators than with that of carnivore seed dispersers.

Our study illustrates how quantifying the circadian patterns of fruit dropping, the diel activity of functionally diverse frugivores, and the matching/mismatching between both patterns can contribute to a better understanding of multispecies plant‐frugivore interactions. Circadian fruiting phenology is an overlooked key attribute for most tropical and temperate fruiting plants, which patterns, mechanisms and outcomes must be fully investigated.

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A Ramanujan subspace and dynamic time warping and adaptive singular value decomposition combined denoising method for low signal‐to‐noise ratio surface microseismic monitoring data in hydraulic fracturing
Authors: Wang Xu‐Lin , Zhang Jian‐Zhong , Huang Zhong‐Lai 
Published: October 2024

AbstractSurface microseismic monitoring is widely used in hydraulic fracturing. Real‐time monitoring data collected during fracturing can be used to perform surface‐microseismic localization, which aids in assessing the effects of fracturing and provides guidance for the process. The accuracy of localization critically depends on the quality of monitoring data. However, the signal‐to‐noise ratio of the data is often low due to strong coherent and random noise, making denoising essential for processing surface monitoring data. To suppress noise more effectively, this paper introduces a novel denoising method that integrates the Ramanujan subspace with dynamic time warping and adaptive singular value decomposition. The new method consists of two steps: First, a Ramanujan subspace is constructed to suppress periodic noise. Then, dynamic time warping and adaptive singular value decomposition are applied to eliminate remaining coherent and random noise. The method has been evaluated using both synthetic and field data, and its performance is compared with traditional microseismic denoising techniques, including bandpass filtering and empirical mode decomposition.
Caffeic acid phenethyl ester ameliorates colistin‐induced nephrotoxicity in rats via modulation of FOXO1/Nrf2/Sirt1 axis
Authors: Nasrullah Mohammed Z. , Neamtalllah Thikryat , Alshibani Mohannad , Bagalagel Alaa A. , Noor Ahmad O. , Bakhsh Hussain T. , Abdel‐Naim Ashraf B. 
Published: October 2024

AbstractBackgroundColistin (Cst) is one of the antimicrobial peptides and is reserved for use against multi‐drug‐resistant Gram‐negative bacteria. However, the clinical value of Cst is limited by its nephrotoxic adverse effects. Caffeic acid phenethyl ester (CAPE) is a honeybee propolis flavonoid recognised for its diverse pharmacological potential. It has demonstrated d antioxidant and anti‐inflammatory properties, as well as protective effects against chemically induced toxicity in variuos biological systems. This study aimed to investigate the impact of CAPE on nephrotoxicity induced in rats by Cst.MethodsAnimals were randomly divided into five groups. Group 1 served as control, group 2 received CAPE (10 mg/kg) orally, group 3 received Cst IP, group 4 received Cst + CAPE (5 mg/kg) and group 5 received Cst + CAPE (10 mg/kg). All treatments were given daily for 10 consecutive days.ResultsCAPE notably attenuated Cst‐inducednephrotoxicity as shown by reducing urea serum levels, creatinine, cystatin C, urinary protein contents and urinary N‐acetyl‐β‐D‐glucosaminidase (NAG). This was confirmed by histological investigations that indicated amelioration of histopathological changes in the kidney architecture as well as the deposition of collagen in renal tissues. CAPE exhibited antioxidant effects supported by the prevention of rise in Cst‐induced lipid peroxidation and depletion of superoxide dismutase and catalase enzymatic activities. In addition, CAPE inhibited the expression of the inflammatory markers including tumour necrosis factor‐α, nuclear factor kappa B and interleukin‐6. These actions were associated with modulation of messenger ribonucleic acid (mRNA) expression of Bax and Bcl‐2 in favour of anti‐apoptosis. CAPE inhibited Cst‐induced rise in forkhead box O1 (FOXO1) expression and downregulation of nuclear factor erythroid 2–related factor 2 (Nrf2) and Sirtuin 1 (Sirt1) immune‐expression.ConclusionCAPE protects against nephrotoxicity induced by Cst in ratsprimarily through its antioxidant, antiinflammatory and antiapoptotic activities. These pritective effects are mediated via modulation of FOXO1/Nrf2/Sirt1 axis.
Income inequality thresholds that should be avoided for governance to promote economic growth with evidence from Africa
Authors: Atemnkeng Johannes Tabi , Senke Ngeh Laura , Ajong Aquilas Nkwetta , Akame Afuge Ramsy 
Published: October 2024

AbstractThis paper examines the role of inequality on the link between governance and economic growth in 44 African countries with data running from 2008 to 2018. Using a system GMM and the generalized least square (GLS) estimators, we establish that the effects of governance on growth are rightly conditioned by inequality. The GMM and GLS estimates portray positive effects of inequality on growth, but only the GMM estimates are significant. For both estimators, the effect of institutions on economic growth is positive and significant. However, inequality retards growth when embedded in selected institutions, which implies a substitution relationship between institutions and inequality on growth. The turning point beyond which inequality begins to contribute negatively to economic growth ranges between 34% and 49% based on the GMM estimates or 40.15% and 44.5% for the GLS analysis depending on the institutional indicator used. Therefore, institutions can only be effective in economic development if income inequality levels of not less than 0.34 and not more than 0.49 are maintained to ensure that inequality does not negate growth. Policy makers of African countries should ensure better income distribution alongside good institutions to achieve sustainable economic growth in the region.
Psychopathology, psychopathy, body management, and undoing in youthful parricide offenders
Authors: Myers Wade , Chan Heng Choon (Oliver) , Safarik Mark , Khalid Zain , Vo Eleanor 
Published: October 2024

AbstractThis study of 21 youthful parricide offenders (YPOs) ages 11–21 examined the relationship between psychopathology, level of psychopathy, and crime scene behaviors, particularly two forms of “body management”: (1) “body movement” and (2) “body alteration.” Undoing, a form of body alteration reflecting psychological rather than practical needs, for example, to lessen guilt or symbolically reverse the killing, was present in one‐third of the sample. The sample shared common characteristics with juvenile parricide offenders overall in that most of them killed one parent, were victims of chronic child abuse, had one or more psychiatric diagnoses (PTSD was most prevalent), used a firearm, and committed the killings at the family home. Unexpectedly, YPOs who were child abuse victims were not more likely to engage in undoing behaviors than non‐abused youth, and over half of the youth with undoing behaviors had elevated psychopathy levels. Three‐quarters of youth who moved victim bodies following the murders had elevated psychopathy levels. Similarly, all three youth who transported bodies away from the crime scene had elevated psychopathy levels and conduct disorder. None of the youth with psychotic symptoms engaged in undoing behaviors, altered victim bodies, moved bodies either within or away from the home, or had an elevated degree of psychopathy; they also most often killed using bladed weapons, whereas the nonpsychotic youth usually used firearms. Studies examining the influence of mental illness and psychopathy level on parricidal behaviors by youth are scarce, and to our knowledge this is the largest study to date investigating this area.
Harnessing network power: Weaponised interdependence in global tax policy
Authors: Christensen Rasmus Corlin 
Published: October 2024

AbstractFor decades, global tax policy has grappled with the challenge of mobile capital, failing to harness the regulatory potential of network power. This oversight has allowed tax havens to flourish, and multinational corporations and wealthy elites to circumvent state authority, undermining national fiscal policies and democratic capacity to meet grand societal challenges, such as climate change and inequality. But recent regulatory innovations pave a different way forward. This article spotlights the dynamics of ‘weaponized interdependence’, suggesting a critical role for strategically targeting global corporate and financial networks in reinvigorating action against tax havens, tax avoidance and tax evasion. Identifying and exploiting network chokepoints – financial institutions, corporate subsidiaries and expert intermediaries – can empower states to reassert their sovereignty and counterbalance the structural advantages of global capital. This approach helps us understand how and why recent regulatory measures have effectively countered financial secrecy, profit shifting and sanctions evasion, repairing public finances and restoring democratic integrity. In an age where weaponised interdependence is predominantly linked to national security, this recasting of global tax policy highlights a progressive path for using network power to develop effective global economic frameworks, strengthen democratic capacity and address contemporary challenges.
Monocentric experience of venetoclax‐based regimen in paediatric refractory and relapsed AML/MDS
Authors: Cousson Sophie , Calvo Charlotte , Goldwirt Lauriane , Simonin Mathieu , Roupret‐Serzec Julie , Dourthe Marie Émilie , Strullu Marion , Baruchel André , Dalle Jean‐Hugues , Brethon Benoît 
Published: October 2024

SummaryBCL‐2 inhibitor venetoclax demonstrates promising efficacy in paediatric relapsed/refractory acute myeloid leukaemia (r/r AML). This retrospective analysis evaluated 12 patients treated with venetoclax‐based regimens under compassionate use for r/r myeloid malignancies. The overall response rate (ORR) was 41.6%, with complete response (CR) achieved in 33% of patients. Three patients successfully underwent allogeneic haematopoietic scell transplantation (HSCT) after venetoclax bridging therapy. Venetoclax demonstrated a favourable safety profile with manageable side effects. These findings suggest venetoclax's potential as a valuable therapeutic option for paediatric r/r AML, particularly for heavily pretreated patients. Further investigation in larger multicentre trials is warranted to refine treatment strategy.
Understanding growth strategies from functional and photosynthetic traits of tree seedlings in southeast Asian seasonally dry evergreen forest
Authors: Pongpattananurak Nantachai , Chowtiwuttakorn Kanisorn , Leksungnoen Nisa , Phumsathan Sangsan , Sonjaroon Weerasin , Ladpala Phanumard , Rungwattana Kanin , Anantaprayoon Nopparat , Kraichak Ekaphan 
Published: October 2024

AbstractSeedlings frequently suffer the highest mortality rate, as they have different requirements for growth and survival from their mature life cycle stage. However, the links between functional traits and photosynthetic traits of tree seedlings, especially from dry evergreen forests, remain largely unexplored. Here, we measured eleven functional traits and six photosynthetic traits of thirty species of tree seedlings from the seasonally dry evergreen forest in Southeast Asia. We explored the relationship between traits and photosynthesis, compared them with their canopy layers when mature, and classified growth strategies. The results showed that photosynthetic measurements were highly correlated with seedling growth traits. The measured functional and photosynthetic traits did not correspond with the canopy layers of the mature trees. Through k‐mean clustering analyses of the tree seedling trait data, two main groups of growth strategies emerged: (1) the “fast‐growing” group, which mainly consists of shade‐intolerant or ‐avoidance species; and (2) the “slow‐growing” group, which consists of shade‐tolerant species. This finding can be applied by future practitioners to select tree seedlings accurately based on their juvenile physiology, which is fundamental to the success of species selection for forest restoration in the face of global climate change.
Non‐floral scent sources of orchid bees: Observations and significance
Authors: Henske Jonas , De Dijn Bart P. E. , Eltz Thomas 
Published: October 2024

AbstractWe observed male euglossines collecting scent at 21 different non‐floral sources in Central and South America, strengthening the view that these sources play a central role in euglossine perfume biology. A Protium tree provided over 50% of the perfumes for Eufriesea corusca and was repeatedly revisited. The co‐occurrence of females collecting resin suggests an evolutionary link to male perfume‐making.Abstract in Spanish is available with online material.
Pembrolizumab efficacy in a tumor mutation burden‐high glioblastoma patient: A case study and implications for precision oncology
Authors: Nishiyama Akihiro , Sato Shigeki , Sakaguchi Hiroyuki , Kotani Hiroshi , Yamashita Kaname , Ohtsubo Koushiro , Sekiya Tomoko , Watanabe Atsushi , Tajima Atsushi , Shimaguchi Chie , Mizuguchi Keishi , Ikeda Hiroko , Kinoshita Masashi , Nakada Mitsutoshi , Takeuchi Shinji 
Published: October 2024

AbstractA glioblastoma (GBM) patient with a high tumor mutation burden (TMB‐high) and mismatch repair deficiency (dMMR) exhibited a significant response to pembrolizumab, an immune checkpoint inhibitor (ICI), despite prior treatment with temozolomide (TMZ), known to induce hypermutation and potential resistance to ICIs. The rapid disease progression, indicated by 80% Ki67 positivity, was markedly countered by the positive outcome of pembrolizumab treatment. This case challenges traditional GBM treatment paradigms, demonstrating the potential of precision oncology in patients with significant TMB and dMMR, and underscores the importance of comprehensive genomic profiling in guiding clinical decisions in GBM management.
Combination of Diosmetin With Chrysin Against Hepatocellular Carcinoma Through Inhibiting PI3K/AKT/mTOR/NF‐кB Signaling Pathway: TCGA Analysis, Molecular Docking, Molecular Dynamics, In Vitro Experiment
Authors: Yu Xiang , Zhang Di , Hu Chengming , Yu Zejun , Li Yang , Fang Cheng , Qiu Yinsheng , Mei Zhinan , Xu Lingyun 
Published: October 2024

ABSTRACTHepatocellular carcinoma (HCC) is the sixth most prevalent malignant tumor. Hepatocellular carcinogenesis is closely linked to apoptosis, autophagy, and inflammation. Diosmetin and chrysin, are two flavonoid compounds, exhibit anti‐inflammatory and anticancer properties. In this study, the TCGA database was utilized to identify differentially expressed genes between normal subjects and HCC patients. Molecular docking and molecular dynamics analyses were employed to assess the binding affinity of chrysin and diosmetin to key proteins in the PI3K/AKT/mTOR/NF‐κB signaling pathway. Western blotting and RT‐qPCR were used to measure the protein and gene expression within this pathway. The results indicated that HCC patients had elevated levels of PI3K, AKT, mTOR, and P65 proteins compared to normal subjects, which adversely affected patient survival. Molecular docking and dynamics studies demonstrated that diosmetin and chrysin are effectively bound to these four proteins. In vitro experiments revealed that the combination of diosmetin and chrysin could induce apoptosis, enhance autophagy, reduce inflammatory mediator production, and improve the tumor cell microenvironment by inhibiting the PI3K/AKT/mTOR/NF‐κB signaling pathway. Notably, the synergy score for the combination of diosmetin (25 μM) and chrysin (10 μM) was 16. Thus, the diosmetin–chrysin combination shows promise as an effective therapeutic approach for hepatocellular carcinoma due to its strong synergistic effect.
Identification of spontaneous patient‐reported complaints related to perianal fistula in patients with Crohn's disease
Authors: Bootsma Lars , Vollebregt Paul F. , van Bodegraven Adriaan A. , van der Horst Danielle , Han‐Geurts Ingrid J. M. , Felt‐Bersma Richelle J. F. 
Published: October 2024

AbstractAimTo identify patient‐reported complaints affecting quality of life in Crohn's disease patients with a perianal fistula, and to compare differences between subgroups.MethodA questionnaire was distributed to 1667 patients from the Dutch Crohn's and Colitis Patients' organization, those patients with Crohn's disease and perianal fistula were included. Patients were asked to report (using free text) their most important fistula‐related complaints affecting their quality of life. All responses were structurally analyzed and categorized. Data comparisons were made between subgroups: women versus men, patients with versus without current presence of a seton, and patients aged ≤40 versus >40 years.ResultsOf 743 respondents (44.6%), 123 patients with Crohn's disease and perianal fistula were included (92 women, median age 41 years [IQR 34–56] and 36 with seton). A total of 776 complaints were allocated to 36 categories, with 19 reported in >10% of patients. Perianal fistula‐related complaints affected nearly all patients (95.9%). Impact on psychological status (71.7% vs. 29.0%; p < 0.0001) and on sexual activities (37.0% vs. 16.1%; p = 0.003) were more common in women than men. Younger patients more often reported insecurity (38.7% vs. 18.0%; p = 0.026), shame (29.0% vs. 11.5%; p = 0.024), and impact on sexual activities (40.3% vs. 23.0%; p = 0.048) than older patients. Patients with a seton more frequently reported self‐experienced malodour (50.0% vs. 23.0%; p = 0.005), physical activity limitations (41.7% vs. 19.5%; p = 0.014), and work/study impact (22.2% vs. 5.7%; p = 0.019).ConclusionWe identified 19 perianal fistula‐related complaints reported by >10% of patients. These complaints may guide improvement of current outcome measures.
Economic freedom and legal gender disparity
Authors: Kramer Claudia Williamson 
Published: October 2024

AbstractUsing a panel dataset from 1970 to 2019, this paper theorizes and empirically demonstrates that countries with higher levels of economic freedom have fewer legal differences between men's and women's economics rights. Specifically, economic freedom promotes equal legal treatment of women to work, get paid, and be entrepreneurs. This finding is robust to controlling for income, political institutional quality, and country and period fixed effects. Furthermore, economic freedom's impact is amplified in democratic countries. The results challenge the prevailing notion that capitalism is detrimental to women, instead providing evidence that economically free countries favor less legal discrimination against women.
Development of an assay for the detection of the federally threatened Florida eastern indigo snake (Drymarchon couperi) using soil eDNA
Authors: Santamaria Carlos A. , Galbraith Emily , Gainsbury Alison M. 
Published: October 2024

AbstractAccurate information on species range contraction is the cornerstone of effective biodiversity conservation. The eastern indigo snake (Drymarchon couperi) is an apex predator in Florida and, similar to many species native to Florida, is threatened by widespread habitat destruction. Environmental deoxyribonucleic acid (eDNA) monitoring of this elusive snake would provide a non‐invasive approach to improve our knowledge of the species' range and distribution. We designed and tested an eDNA assay that can detect the presence of D. couperi from soil samples from their natural scrub habitat in Florida. We validated our assay in silico, in vitro, and in situ. Furthermore, we investigated the influence of temperature and humidity on the degradation rate of eDNA over time. We successfully amplified the cytochrome b gene for D. couperi at concentrations as low as 3 × 10−3 ng/μL and successfully detected the presence of D. couperi in 2 of 30 in situ field soil samples. The degradation experiment resulted in detectable DNA for 10 days. Interestingly, temperature and humidity had no effect on the degradation rate of eDNA in our experimental conditions. This study provides support for soil eDNA applications to detect the presence of a federally threatened species in their natural environment bolstering our ability to monitor the conservation and management of imperiled species. Environmental DNA provides an additional conservation tool to quickly and effectively monitor species range shifts driven by multiple anthropogenic stressors to promote the persistence of imperiled species.
Seasonality Structures Avian Functional Diversity and Niche Packing Across North America
Authors: Keyser Spencer R. , Pauli Jonathan N. , Fink Daniel , Radeloff Volker C. , Pigot Alex L. , Zuckerberg Benjamin 
Published: October 2024

ABSTRACTAssemblages in seasonal ecosystems undergo striking changes in species composition and diversity across the annual cycle. Despite a long‐standing recognition that seasonality structures biogeographic gradients in taxonomic diversity (e.g., species richness), our understanding of how seasonality structures other aspects of biodiversity (e.g., functional diversity) has lagged. Integrating seasonal species distributions with comprehensive data on key morphological traits for bird assemblages across North America, we find that seasonal turnover in functional diversity increases with the magnitude and predictability of seasonality. Furthermore, seasonal increases in bird species richness led to a denser packing of functional trait space, but functional expansion was important, especially in regions with higher seasonality. Our results suggest that the magnitude and predictability of seasonality and total productivity can explain the geography of changes in functional diversity with broader implications for understanding species redistribution, community assembly and ecosystem functioning.