bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thrombodynamics test efficacy in predicting thromboembolic complications in patients with lymphoproliferative disorders
Authors: Ignatyev S. V. , Lyanguzov A. V. , Paramonov I. V. 
Published: September 2024

Background. Patients with lymphoproliferative disorders (LPD) are at increased risk of developing venous thromboembolic complications (VTEC). Existing risk assessment systems for VTEC (Khorana, Vienna, ThroLy, etc.) do not have sufficient prognostic accuracy in this patient population. The thrombodynamics test may improve the prognosis of VTEC and optimize the prophylactic use of anticoagulants in these patients.Aim. To evaluate thrombodynamics test efficacy in assessing the risk of venous VTEC in LPD patients.Materials and methods. Medical data of 990 patients with LPD who received treatment at the Kirov Research Institute of Hematology and Blood Transfusion from 2019 to 2021 were analyzed. Coagulation parameters were evaluated at admission, as well as the risk of developing VTEC by prognostic scales Khorana, Vienna, ThroLy, SAVED, and Padua. Data are presented as median and interquartile range. Mann–Whitney U test was used to compare two independent groups. Correlation was determined using Spearman’s rank correlation. Logistic regression was used to determine dependencies. The diagnostic value of laboratory tests was established through ROC analysis.Results. In the overall cohort of LPD patients, the incidence of VTEC was 2.1 %. Screening coagulogram parameters in these patients did not exceed reference values. Patients with LPD who developed VTEC initially showed a significant increase in clot velocity (V), initial growth velocity (Vi), and clot size (Cs). It was found that the presence of spontaneous clots significantly increased the chances of developing a thrombotic event (odds ratio 3.99; 95 % confidence interval 1.56–10.22; p = 0.004). It was also determined that V velocity is an independent predictor of VTEC (adjusted odds ratio 1.053; 95 % confidence interval 1.016–1.090; p = 0.0046). The AUC determined by ROC analysis for the V parameter was 0.722 (threshold value 30.7 μm/min sensitivity 81 %, specificity 57.4 %).Conclusion. Clot growth velocity is the most informative parameter of thrombodynamics test in predicting VTEC.
Retrospective analysis of own long-term experience in studying the BCR::ABL kinase domain mutational status in patients with chronic myeloid leukemia
Authors: Kustova D. V. , Motyko E. V. , Kirienko A. N. , Gert T. N. , Leppyanen I. V. , Bakay M. P. , Efremova E. V. , Morozova E. V. , Lomaia E. G. , Shuvaev V. A. , Sidorkevich S. V. , Martynkevich I. S. 
Published: September 2024

Background. Most patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors achieve durable optimal responses. Loss of the achieved molecular response is observed in 15–30 % of patients. Mutations in the BCR::ABL kinase domain are one of the most common mechanisms for the development of resistance to tyrosine kinase inhibitors.Aim. To conduct a retrospective analysis of the BCR::ABL kinase domain mutational profile in patients with CML observed at the Russian Research Institute of Hematology and Transfusiology from 2012 to 2023. To assess the impact of mutations type and number on the rate of achieving a major molecular response (MMR). To study the risk of MMR loss depending on the therapy line and existing mutational status.Materials and methods. 1831 patients with CML were examined at different times. The mutational status of the BCR::ABL kinase domain was analyzed by direct Sanger sequencing. A standard cytogenetic study was carried out using GTG banding technology with the analysis of at least 20 metaphase plates.Results. Mutations in the BCR::ABL kinase domain were identified in 27.6 % of the total studied patients. The most common mutation, 6.3 % in the overall group or 22.7 % among patients with mutations, was the T315I mutation. Additional chromosomal aberrations (ACAs) were detected in Ph-positive cells in 20.5 % of patients, in Ph-negative clones in 3.9 % of cases (p = 0.0001). The frequency of ACAs detection did not statistically significantly differ (p = 0.25) between patients with BCR::ABL mutations (23.5 %) and with a negative mutation status (17.7 %), and the presence of mutations in the kinase domain did not correlate with ACAs in Ph-positive clones (p = 0.73). However, the frequency of T315I mutation detection in Ph-positive cells had significant differences: 40.9 % in combination with ACAs and 21 % without ACAs (p = 0.032). Patients with the T315I mutation had significantly worse MMR than patients with mutations in other BCR::ABL regions (p = 0.04) and patients without mutations (p = 0.02). The probability of MMR achieving did not differ significantly between patients with different numbers of BCR::ABL mutations (p = 0.14). Loss of MMR occurred more often in patients with mutations (p = 0.04) and not depend on the line of therapy (p = 0.03).Conclusion. For complete monitoring and optimal choice of therapy, CML patients require not only monitoring of BCR::ABL relative expression level, but also standard cytogenetic and analysis of the mutational status.
IMPLEMENTASI METODE AHP DAN MOORA UNTUK PENGAMBILAN KEPUTUSAN PENENTUAN KREDIT PADA KSPPS AMANAH INSANI MAKMUR BANTUL
Authors: Nuraska Dina , Dewa Weda Adistianaya , Sophia Evy 
Published: September 2024

Abstrak : Koperasi Simpan Pinjam Pola Syariah (SPSLC) Amanah Insani Makmur yang berlokasi di Gedongan, Panjangrejo, Kecamatan Pundong, Kabupaten Bantul, Daerah Istimewa Yogyakarta, mengalami peningkatan kredit macet sebesar 32 percent akibat proses pengambilan keputusan yang kurang optimal, bersifat subjektif, dan tidak mempertimbangkan riwayat transaksi anggota. Untuk mengatasi masalah ini, diperlukan perubahan kebijakan dalam pengambilan keputusan dengan pendekatan berbasis data, yaitu dengan menggabungkan metode AHP (Analytical Hierarchy Process) untuk pembobotan kriteria dan MOORA (Multi-Objective Optimization on the basis of Ratio Analysis) untuk pemeringkatan alternatif. Pengujian dengan 30 sampel data menunjukkan bahwa pendekatan gabungan ini menghasilkan penilaian kredit yang lebih realistis dan objektif.
A clinicoepidemiological study of chronic and recurrent leg ulcers
Authors: Wilson Anushka , Muppalla Bandhavi , Koneru Yamini Vijaya Sai , Dangi Priyanshi , Nadkarni Nitin , Patil Sharmila , Godse Kiran Vasant 
Published: September 2024

Chronic leg ulcers (CLU) are chronic diseases, which are associated with significant morbidity and exert health burden on the patients. Varied heterogeneity in the type of aetiology, risk factors, and comorbidities have been observed in individuals with CLU. Aprospective, cross-sectional, observational type of descriptive study carried out in the department of Dermatology, Venereology and Leprosy at a tertiary care teaching hospital in Navi Mumbai. Adult patients with clinical evidence of chronic leg ulcer were enrolled. Patient’s quality of life (QOL) was assessed by Dermatology Life Quality Index (DLQI) scale. The mean age of the sample was 42.07 ± 9.3. The male to female ratio was 1.38:1. The most common occupation encountered was farmers (35%), followed by housewives (13%), shopkeepers (8%), cook & students (7%). Around 76 % of the patients of leg ulcer were having associated co-morbidities among which Diabetes was commonly encountered. The most common etiological diagnosis were venous ulcers (31%), followed by diabetic ulcer (26%), trophic ulcers (25%), traumatic ulcer (7%), leucocytoclastic vasculitis (7%), arterial ulcer and pyoderma gangrenosum (4%). The leg ulcer had adversely impacted the QOL ranging from moderately to extremely large with majority (80%) of the patients having very large impact on QOL. Chronic leg ulcers are long term conditions with varying aetiologies and risk factors. They are associated with significant impairment of patient’s quality of life.
Aprendizagem autoral no contexto das TDICS: análise de uma Plataforma Educacional
Authors: Matoso Lara Gabriela , Giordani Estela Maris 
Published: September 2024

O artigo problematiza a aprendizagem autoral no contexto de uma Plataforma Educacional (PE). O objetivo da pesquisa é analisar se, na visão de profissionais que atuam na área da Educação, as ferramentas, que integram a PE investigada, possibilitam interação, usabilidade, engajamento e comprometimento entre os sujeitos, promovendo a autoralidade do aprendiz. É fundamental entender que o processo de aprendizagem é orientado pelas habilidades, conhecimentos e atitudes de cada indivíduo (Brasil, 2018), sendo papel da educação potencializar esse conjunto de competências. Isso é possível através do educar pela/para a pesquisa, no qual, dentre seus princípios, estão a autoralidade, autenticidade e protagonismo do aprendiz, garantidos no paradigma da aprendizagem (Demo, 2011; 2018). A pesquisa desenvolvida é de abordagem qualitativa, caracterizada como exploratória de campo. A coleta de dados foi realizada por meio de entrevista semiestruturada, com doze profissionais da educação, denominados Especialistas. Os resultados demonstraram que, na compreensão dos Especialistas, a PE avaliada tem potencial para transformar as práticas pedagógicas, possibilitando a autoralidade dos aprendizes e o protagonismo responsável, em suas aprendizagens. Pretende-se, com a pesquisa, contribuir para as discussões a respeito da aprendizagem autoral, especialmente na sua relação com as tecnologias. Ainda pode fornecer parâmetros de análise a Plataformas Educacionais a serem implementadas em sistemas públicos e privados de educação, seguindo a Política Nacional de Educação Digital (PNED) (Brasil, 2023).
Analysis of Parkinson’s disease patients with gastrointestinal symptoms using structural and functional magnetic resonance imaging
Authors: TAI Yuchao , Huang Wei , Zhu Yongyun , Liu Bin , Wang Fang , Liu Zhaochao , Liang Chunyu , Tian Jin , Yang Hongju , Ren Hui , Yang Xinglong 
Published: September 2024

Abstract

Objective: Gastrointestinal symptoms are one of the most common non-motor symptoms in Parkinson’s disease. This study aimed to investigate the neuroimaging mechanisms underlying gastrointestinal symptoms associated with Parkinson’s disease using functional connectivity and voxel-based morphometry.
Methods: The study included 50 healthy controls, 71 Parkinson’s disease patients without gastrointestinal symptoms and 84 patients with gastrointestinal symptoms. Differences in gray matter volume among the three groups were assessed. Given a significant decrease in gray matter volume in the right cerebellar hemisphere, it was selected as the seed region for functional connectivity analysis.
Results: The Parkinson’s disease patients with gastrointestinal symptoms showed significant differences in disease duration, levodopa equivalents daily dose, Hoehn and Yahr stage, unified Parkinson's disease rating scale part Ⅲ, Hamilton anxiety scale, Scales for Outcomes in Parkinson’s disease-Autonomic, non-motor symptom scale, Montreal cognitive assessment, and orthostatic hypotension compared to the patients without gastrointestinal symptoms (p<0.05). Lower gray matter volume was observed in the group with gastrointestinal symptoms, particularly in the bilateral cerebellum hemisphere and the left superior temporal gyrus. Compared to the group without gastrointestinal symptoms, functional connectivity between the right cerebellar hemisphere and the right medial and lateral cingulate gyrus and left middle temporal lobe was significantly increased.
Conclusions: Parkinson’s disease patients with gastrointestinal symptoms present with a prolonged disease course and increased severity of both motor and non-motor symptoms. The gastrointestinal symptoms in Parkinson’s disease patients may be associated with structural and functional brain alterations.
Federated Task-Adaptive Learning for Personalized Selection of Human IVF-derived Embryos
Authors: Wang Guangyu , Gao Tianrun , Yang Yuning , Wang Kai , Gao Yuanxu , Ma Li-Shuang , Chen Lei , Liu Guangdong , Zhang Ping , Liu Xiaohong 
Published: September 2024

Abstract

In-vitro fertilization (IVF) offers a solution for couples facing infertility challenges. However, the success of IVF, particularly in achieving live-birth outcomes, heavily depends on embryologists to conduct morphological assessments of fertilized embryos, a process that is both time-consuming and labor-intensive. While artificial intelligence (AI) has gained recognition for its potential to automate embryo selection, the application of deep learning (DL) is constrained by privacy concerns associated with the requirement for centralized training on extensive datasets. In this paper, we have developed a distributed DL system, termed ‘FedEmbryo’, tailored for personalized embryo selection while preserving data privacy. Within FedEmbryo, we introduce a Federated Task-Adaptive Learning (FTAL) approach with a hierarchical dynamic weighting adaption (HDWA) mechanism. This approach first uniquely integrates multi-task learning (MTL) with federated learning (FL) by proposing a unified multitask client architecture that consists of shared layers and task-specific layers to accommodate the single- and multi-task learning within each client. Furthermore, the HDWA mechanism mitigates the skewed model performance attributed to data heterogeneity from FTAL. It considers the learning feedback (loss ratios) from the tasks and clients, facilitating a dynamic balance to task attention and client aggregation. Finally, we refine FedEmbryo to address critical clinical scenarios in the IVF processes, including morphology evaluation and live-birth outcomes. We operate each morphological metric as an individual task within the client's model to perform FTAL in morphology evaluation and incorporate embryo images with corresponding clinical factors as multimodal inputs to predict live-birth outcomes. Experimental results indicate that FedEmbryo outperforms both locally trained models and state-of-the-art (SOTA) FL methods. Our research marks a significant advancement in the development of AI in IVF treatments.
Effects of the Informed Health Choices secondary school intervention after one year: a prospective meta-analysis using individual participant data
Authors: Chesire Faith , Mugisha Michael , Ssenyonga Ronald , Rose Christopher J. , Nsangi Allen , Kaseje Margaret , Sewankambo Nelson K. , Oxman Matt , Rosenbaum Sarah E. , Moberg Jenny , Dahlgren Astrid , Lewin Simon , Venkateswaran Mahima , Papadopoulou Eleni Zoumpoulia , Oxman Andrew David 
Published: September 2024

Abstract

Background
The aim of this prospective meta-analysis was to synthesize the results of one-year follow-up data from three cluster-randomized trials of an intervention designed to teach lower secondary school students to think critically about health choices.
Methods
We conducted the trials in Kenya, Rwanda, and Uganda. The intervention included providing a 2-3-day teacher training workshop, and digital resources for ten lessons. The intervention focused on nine key concepts. We did not intervene in control schools. The primary outcome was a passing score on a test (≥ 9 of 18 multiple-choice questions answered correctly). We performed random effects meta-analyses to estimate the overall intervention effects. We calculated learning retention as the test results in the intervention schools after one year relative to just after the intervention, adjusted for chance.
Results
Altogether, 244 schools (11,344 students) took part in the three trials. Follow-up data was collected for 8298 students (73%). The overall odds ratio for the primary outcome after one year was 3.6 (95% CI: 1.9–7.1; p = 0.0001) in favor of the intervention, whereas it was 5.5 (95% CI: 3.0-10.2) just after the intervention. This corresponds to 25.6% (95% CI: 21.1–30.0%) more students in the intervention schools passing the test after one year versus 33.3% (95% CI: 28.7–37.8%) just after the intervention. Overall, 2273 (52.6%) of 4324 students in intervention schools had a passing score after one year compared to 3397 (58.1%) of 5846 students just after the intervention, indicating 88.3% learning retention.
Conclusions
One year after the intervention, we still found a positive effect on the ability of students to think critically about health choices, but 5.5% fewer students in the intervention schools had a passing score. The certainty of the evidence was also lower due to 27% of students being lost to follow-up.
Protocol registration:
The protocol for this prospective meta-analysis was registered with PROSPERO May 31, 2022, ID 336580. The three randomized trials were registered in the Pan African Clinical Trial Registry February 15, 2022, PACTR202203880375077; April 5, 2022, PACTR20220488391731; and April 14, 2022, PACTR202204861458660.
Real-Time Stool PCR: A Game Changer for Acute Gastroenteritis in the Pediatric Emergency Department
Authors: BARUT Dogan , TURAN Caner , YURTSEVEN Ali , BOLUK Ezgi , AYDEMIR Sohret , SAZ Eylem Ulas 
Published: September 2024

Abstract

Background
According to the World Health Organization (WHO), two-thirds of child mortalities are attributable to infectious diseases, with acute gastroenteritis being the second most common cause. The detection of bacterial gastrointestinal pathogens (BGP) through conventional culture (CC) and microscopy is both laborious and time-consuming, particularly in the emergency department (ED) setting. Our study aims to compare CC and real-time PCR (RT-PCR) methods in the detection of BGPs in the pediatric ED and to examine their impact on the use of antibiotics and workflow of the ED
Material and methods
This prospective observational study was conducted at the tertiary academic pediatric ED for three years. Children presenting with acute gastroenteritis suspected to be of bacterial etiology were enrolled in the study. Stool samples were collected from 257 children and studied and analyzed using microscopy, both CC and RT-PCR methods. Real-time PCR and CC detected four major BGP (Salmonella spp., Shigella spp./enteroinvasive Escherichia coli, Campylobacter spp. (jejuni and coli) and Shiga toxin-producing organisms (STEC, Shigella dysenteriae). Demographic characteristics, clinical findings, and, if indicated, blood tests were obtained.
Results
Overall 257 patients were included. The mean age was 4.25 years, and 55.3% were male. The most common complaints were diarrhea (93%), vomiting (53.7%), and fever (53.7%). Enteropathogens were identified in 30.7% and 39.3% of the children by CC and RT-PCR, respectively. The most commonly detected pathogens by both CC and RT-PCR were similar: Campylobacter spp(13%-21%), Salmonella spp(11.3%-14.8%), and Shigella spp.(2.3%-3.1%), respectively. Microscopic stool analyses were positive in 68.4% of children, with WBCs in 41.8% and both WBCs and RBCs in 26.6%. Patients who have positive microscopy are more likely to have positive CC. The mean time to results for CC was 61.9 hours for positive and 40.8 hours for negative cases. RT-PCR results were significantly faster (7.87 hours) than CC (61.9 hours for positive results) (p < 0.001). Blood tests were performed on 123 patients, showing higher mean leukocyte and absolute neutrophil counts in positive PCR cases. Mean CRP was significantly higher in patients with positive results (6.67 mg/dL) than in those with negative results (2.1 mg/dL) (p < 0.001). Only 12.8% of patients were admitted to the ward, with one requiring ICU admission.
Conclusion
Real-time PCR significantly improved the detection rates of bacterial gastrointestinal pathogens, reduced inappropriate antibiotic use, and substantially decreased the time to preliminary results. Additionally, it facilitated the timely discharge of patients from the ED, contributing to shorter hospital stays.
Development and Validation of a Multivariate Nomogram for Predicting Retinopathy of Prematurity in Infants with Gestational Age ≤ 34 Weeks
Authors: Shen Leilei , Zeng Juan , Tao Min , Zhang Chenghuan , Chen Sheng 
Published: September 2024

Abstract

Purpose
To delineate risk factors and develop a predictive nomogram for retinopathy of prematurity (ROP) in infants with gestational age (GA) ≤ 34 weeks.
Methods
We conducted a comprehensive retrospective analysis of infants with GA ≤ 34 weeks, divided into ROP and non-ROP groups based on fundus screening results. Clinical and laboratory data were collected to identify risk factors associated with ROP. Multivariable logistic regression was performed to identify independent predictors, and a nomogram was developed to predict the occurrence of ROP in infants with GA ≤ 34 weeks.
Results
Our analysis identified five independent risk factors for ROP in infants with GA ≤ 34 weeks: hypertensive disorders of pregnancy (HDP), number of blood transfusions, oxygen therapy time (OTT), oxygen therapy concentration (OTC) > 50%, and blood glucose spikes in the first postnatal week. These predictors were incorporated into a nomogram to estimate individual ROP risk. The predictive model achieved a C-index of 0.923 (95% CI: 0.888–0.959), indicating high predictive accuracy. Internal validation of the nomogram demonstrated excellent calibration and practical utility for clinical decision-making.
Conclusions
The validated nomogram, based on five critical factors, provides clinicians with a reliable tool for assessing the risk of developing ROP in infants with GA ≤ 34 weeks. This tool has the potential to improve outcomes by facilitating timely and appropriate therapeutic interventions.
New Chloroquine Derivatives: Synthesis, Characterisation, Antiplasmodial and Antioxidant Evaluations
Authors: Maduechesi Chukwuebuka F. , Onoabedje Efeturi A. , Ezema Benjamin E. , Okafor Sunday N. , Ezeugwu Chikaodili J. 
Published: September 2024

Abstract

Quinoline is a privileged pharmacophore in many bioactive compounds possessing antimalarial activity. In this paper, some novel 4-aminoquinoline derivatives were synthesized in good yields in order to investigate their antimalarial and antioxidant properties. This was achieved by combining Nʹ-(7-chloroquinolin-4-yl)propane-1,3-diamine 7 with various boc-amino acids. Amongst the synthesized derivatives, tert-buty(1-((3-((7-chloroquinolin-4- yl)amino)propyl)amino)-4-methyl-1-oxopenta-2-yl)carbamate (IC50 = 1.11 mg/mL) and tert- butyl 2-((3-((7-chloroquinolin-4-yl)amino)propyl)carbamoyl)pyrrolidine-1-carboxylate (IC50 = 1.30 mg/mL) exhibit relatively better antiplasmodial activities compared to chloroquine diphosphate (IC50 = 0.84 mg/mL). In addition, tert-butyl(2-((3-((7-chloroquinolin-4- yl)amino)propyl)amino)-2-oxoethyl)carbamate exhibited better antioxidant activity (IC50 = 0.48 mg/mL) than ascorbic acid (IC50 = 0.41 mg/mL).
Molecular characteristics of feline coronavirus in South Korea, 2016–2023
Authors: Kim Sung-Hee , Lee Kyoung-Ki , Lee Ilseob , Shin Go-Eun , Jang Ji-Ung , Joo Yoon-A , Lee Kyunghyun , Kim Ah-Young , Ku Bok-Kyung , Jeoung Hye-Young 
Published: September 2024

Abstract

Feline coronavirus (FCoV) is highly contagious and ubiquitous in cat populations. FCoV is classified into two serotypes, types I and II, each including two biotypes, feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV). In this study, we detected FCoV in cases obtained by the Animal and Plant Quarantine Agency (APQA) from 2016 to 2023, and analyzed genetic diversity of FCoV for currently circulation in Korea. In a total of 925 cats, FCoV was detected in 294 cats (31.8%). Among the 73 cases with a final diagnosis, 47.9% (35/73) were finally found to be FIPV, and 52.1% (38/73) were confirmed to be FECV. Of the 294 FCoV-positive cases, 24 partial S genes were successfully sequenced. Partial S2 subunit sequencing indicated that types I and II accounted for 91.7% (22/24) and 8.3% (2/24) of the cases, respectively. One case, 23D103, contained a six-nucleotide deletion in the S gene, which was distinctive of Korean types. Phylogenetic analysis of types I and II showed clear discrimination based on the S gene. Types I and II also exhibited 63.2–99.8% nucleotide acid homology with the S gene of reference strains. This study provides updated information regarding the current infection status and molecular characteristics of FCoV in Korea.