bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biological characteristics of human menstrual blood‐derived endometrial stem cells
Authors: Liu Yanli , Niu Rongcheng , Yang Fen , Yan Yan , Liang Shengying , Sun Yuliang , Shen Ping , Lin Juntang 
Published: December 2017

AbstractSuccessful isolation of human endometrial stem cells from menstrual blood, namely menstrual blood‐derived endometrial stem cells (MenSCs), has provided enticing alternative seed cells for stem cell‐based therapy. MenSCs are enriched in the self‐regenerative tissue, endometrium, which shed along the periodic menstrual blood and thus their acquisition involves no physical invasiveness. However, the impact of the storage duration of menstrual blood prior to stem cell isolation, the age of the donor, the number of passages on the self‐renewing of MenSCs, the paracrine production of biological factors in MenSCs and expression of adhesion molecules on MenSCs remain elusive. In this study, we confirmed that MenSCs reside in shedding endometrium, and documented that up to 3 days of storage at 4°C has little impact on MenSCs, while the age of the donor and the number of passages are negatively associated with proliferation capacity of MenSCs. Moreover, we found that MenSCs were actually immune‐privileged and projected no risk of tumour formation. Also, we documented a lung‐ and liver‐dominated, spleen‐ and kidney‐involved organic distribution profile of MenSC 3 days after intravenous transfer into mice. At last, we suggested that MenSCs may have potentially therapeutic effects on diseases through paracrine effect and immunomodulation.
An update of the evidence on the potential impact of periodontal therapy on diabetes outcomes
Authors: Madianos Phoebus N. , Koromantzos Panagiotis A. 
Published: December 2017

AbstractAimTo provide an update of the systematic review by Engebretson and Kocher J Clin Periodontol. 2013 Apr;40 Suppl 14:S153 on the effect of periodontal therapy on glycaemic control of people with diabetes.MethodsPubMed Literature search restricted to meta‐analyses published from 2013 to the present was conducted. The search resulted in seven meta‐analyses of RCTs.ResultsReduction in HbA1c at 3–4 months was reported in all reviews for the treatment group ranging from −0.27% (95% CI: −0.46, −0.07, p = .007) to −1.03% (95% CI: 0.36, −1.70, p = 0.003). At 6 months post‐treatment, an HbA1c reduction ranging from −0.02 (95% CI: −0.20, −0.16, p = .84) to −1.18% (95% CI: 0.72%, 1.64%, p < 0.001) was reported.Clinical relevanceThe magnitude of the reduction in HbA1c, which is found to be associated with non‐surgical periodontal treatment in patients with diabetes, seems to have clinically significant effects on systemic health, and thus should have a place in the treatment of diabetic patients.ConclusionsPeriodontal treatment (SRP) results in a statistically significant reduction in HbA1C levels at 3 months, with a lower reduction at 6 months.
Role of heat shock factor 1 expression in the microenvironment of intrahepatic cholangiocarcinomas
Authors: Kawashita Yoichiro , Morine Yuji , Saito Yu , Takasu Chie , Ikemoto Tetsuya , Iwahashi Shuichi , Teraoku Hiroki , Yoshikawa Masato , Imura Satoru , Yagi Toshiyuki , Shimada Mitsuo 
Published: December 2017

AbstractBackground and AimHeat shock factor 1 (HSF1), a master regulator of heat shock response, has been shown to play a multifaceted role in cancer progression. However, the clinical significance and biological effect of HSF1 expression in intrahepatic cholangiocarcinoma (IHCC) remain unknown.MethodsForty‐nine patients with IHCC who underwent hepatic resection were enrolled in this study. HSF1 expression in tumor tissue was determined by immunohistochemistry, and patients were divided into two groups, those with high (n = 20) and low (n = 29) HSF1 expression. Clinicopathological factors including prognosis were compared in these two groups.ResultsHSF1 expression was significantly higher in tumors than in normal tissue. The overall survival rate was significantly lower in patients with high than low HSF1. Multivariate analysis showed that high HSF1 expression was a factor independently prognostic of patient survival.ConclusionHigh HSF1 expression in tumor tissues may be a prognostic biomarker in patients with IHCC.
High prevalence of diabetes mellitus, hypertension and obesity among persons with a recorded diagnosis of intellectual disability or autism spectrum disorder
Authors: Flygare Wallén E. , Ljunggren G. , Carlsson A. C. , Pettersson D. , Wändell P. 
Published: December 2017

AbstractBackgroundObesity and lack of physical activity are frequently reported in persons with intellectual disability (ID) or autism spectrum disorder (ASD). We hypothesised a higher prevalence of diabetes and hypertension in this population.MethodWe used administrative data for all primary and specialist outpatient and inpatient healthcare consultations for people with at least one recorded diagnosis of diabetes mellitus, hypertension or obesity from 1998 to 2015. Data were drawn from the central administrative database for Stockholm County, Sweden. It was not possible to separate data for type 1 and type 2 diabetes. We stratified 26 988 individuals with IDs or ASD into three groups, with Down syndrome treated separately, and compared these groups with 1 996 140 people from the general population.ResultsCompared with the general population, men and women with ID/ASD had 1.6–3.4‐fold higher age‐adjusted odds of having a registered diagnosis of obesity or diabetes mellitus, with the exception of diabetes among men with Down syndrome. A registered diagnosis of hypertension was only more common among men with ID/ASD than in the general population.ConclusionsDiabetes and blood pressure health screening, along with efforts to prevent development of obesity already in childhood, are necessary for individuals with IDs and ASD. We believe that there is a need for adapted community‐based health promotion programmes to ensure more equitable health for these populations.
Petrogenesis and deformation history of the lawsonite‐bearing blueschist facies metabasalts of the Diamante‐Terranova oceanic unit (southern Italy)
Authors: Fedele L. , Tramparulo F. D'A. , Vitale S. , Cappelletti P. , Prinzi E. P. , Mazzoli S. 
Published: December 2017

AbstractThe Neotethyan oceanic Diamante‐Terranova unit (DIATU; southern Apennines–Calabria–Peloritani Terrane system) includes basic rocks that during the Cenozoic were subducted and metamorphosed to lawsonite‐blueschist facies conditions. Petrological and structural observations (both at the meso‐ and micro‐scale) show that lawsonite growth was continuous during three distinctive ductile deformation stages (D1–D3). These likely occurred close to the metamorphic peak, estimated at 350–390°C and 0.9–1.1 GPa, producing an equilibrium assemblage made of blue Na‐amphibole, lawsonite, chlorite and pumpellyite. Locally, pods dominated by quartz and epidote (plus chlorite, calcite and green Ca‐amphibole) developed at similar conditions (350–370°C, 0.8–0.9 GPa). Post‐peak evolution during the final exhumation of the DIATU along the subduction channel, also consisted of three deformation stages, defined by folding (D4) and normal faulting (D5) and finally by strike‐slip faulting (D6), affecting both the blueschist unit and the unconformably overlying Tortonian conglomerates. Vorticity analysis on syn‐tectonic lawsonite crystals indicates that severe flattening occurred during the D2 stage, with a significant secondary non‐coaxial strain component along the W–E plane. This is associated with an eastward tectonic vergence, consistent with the subsequent D3 and D4 folding stages characterized by a dominant ENE tectonic transport. It is suggested that exhumation started from the D2 stage and continued during D3 at similar HP/LT metamorphic conditions. The widespread occurrence of unreacted lawsonite crystals suggests that exhumation was very fast and supports the idea that concurrent ductile deformation might play a role in its preservation.
Segmentation of clustered cells in negative phase contrast images with integrated light intensity and cell shape information
Authors: WANG Y. , WANG C. , ZHANG Z. 
Published: December 2017

SummaryAutomated cell segmentation plays a key role in characterisations of cell behaviours for both biology research and clinical practices. Currently, the segmentation of clustered cells still remains as a challenge and is the main reason for false segmentation. In this study, the emphasis was put on the segmentation of clustered cells in negative phase contrast images. A new method was proposed to combine both light intensity and cell shape information through the construction of grey‐weighted distance transform (GWDT) within preliminarily segmented areas. With the constructed GWDT, the clustered cells can be detected and then separated with a modified region skeleton‐based method. Moreover, a contour expansion operation was applied to get optimised detection of cell boundaries. In this paper, the working principle and detailed procedure of the proposed method are described, followed by the evaluation of the method on clustered cell segmentation. Results show that the proposed method achieves an improved performance in clustered cell segmentation compared with other methods, with 85.8% and 97.16% accuracy rate for clustered cells and all cells, respectively.
The effect of the solution‐focused approach on nutrition–exercise attitudes and behaviours of overweight and obese adolescents: Randomised controlled trial
Authors: Akgul Gundogdu Nurcan , Sevig Emine Umit , Guler Nuran 
Published: December 2017

Aims and objectivesTo assess the effect of the solution‐focused approach interview technique on overweight/obese adolescents’ nutrition–exercise attitudes and behaviours.BackgroundObesity is a serious health problem for all age groups, particularly adolescents; therefore, it is important for adolescents to develop healthy nutrition habits and acquire exercise behaviours. Unless healthy nutrition–exercise behaviours are acquired, obesity can develop in adolescence, continue in adulthood. Focusing on solutions can be effective for overweight/obese adolescents to develop healthy nutrition–exercise behaviours.DesignA pretest–post‐test randomised controlled trial design was used.MethodsThe study included 32 overweight/obese adolescents (16 for intervention group, 16 for control group) aged 12–13 years who attended a health centre and met the inclusion criteria. The solution‐focused Approach interview technique was applied to the intervention group. Eight solution‐focused interviews were conducted with each adolescent at 2‐week intervals (interview length 30–45 min). For each group, anthropometric, metabolic measurement follow‐ups were conducted in the first and sixth months. The data were evaluated using independent samples t test, Mann–Whitney U, Wilcoxon test, respectively, for normally, non‐normally distributed variables. The categorical variables were compared using chi‐square test. The value p < .05 was accepted to be statistically significant.ResultsThe study concluded that the intervention group's healthy nutrition–exercise attitude and behaviour scale scores were higher in the sixth month follow‐up; difference between the follow‐ups was significant (p < .001). The study also showed that the intervention group lost 2.6–11 kg, while the control group gained 2.9–9 kg. A significant positive relationship was found between the nutrition–exercise attitude and behaviour scores.ConclusionEight interviews during 6 months were adequate for positive development of their nutrition–exercise attitudes and behaviours; significant decrease in their weight, BMI percentile, BMI‐SDS values; and normal metabolic values.Relevance to clinical practiceThe solution‐focused approach interview technique enabled overweight/obese adolescents’ weight and blood glucose to be controlled against obesity. It helped them acquire healthy nutrition–exercise behaviours. Thus, it can be used as support for treatment of obesity in adolescents.
Towards a standardised definition for fundamental care: A modified Delphi study
Authors: Feo Rebecca , Conroy Tiffany , Jangland Eva , Muntlin Athlin Åsa , Brovall Maria , Parr Jenny , Blomberg Karin , Kitson Alison 
Published: December 2017

Aims and objectivesTo generate a standardised definition for fundamental care and identify the discrete elements that constitute such care.BackgroundThere is poor conceptual clarity surrounding fundamental care. The Fundamentals of Care Framework aims to overcome this problem by outlining three core dimensions underpinning such care. Implementing the Framework requires a standardised definition for fundamental care that reflects the Framework's conceptual understanding, as well as agreement on the elements that comprise such care (i.e., patient needs, such as nutrition, and nurse actions, such as empathy). This study sought to achieve this consensus.DesignModified Delphi study.MethodsThree phases: (i) engaging stakeholders via an interactive workshop; (ii) using workshop findings to develop a preliminary definition for, and identify the discrete elements that constitute, fundamental care; and (iii) gaining consensus on the definition and elements via a two‐round Delphi approach (Round 1 n = 38; Round 2 n = 28).ResultsDelphi participants perceived both the definition and elements generated from the workshop as comprehensive, but beyond the scope of fundamental care. Participants questioned whether the definition should focus on patient needs and nurse actions, or more broadly on how fundamental care should be delivered (e.g., through a trusting nurse–patient relationship), and the outcomes of this care delivery. There were also mixed opinions whether the definition should be nursing specific.ConclusionsThis study has initiated crucial dialogue around how fundamental care is conceptualised and defined. Future work should focus on further refinements of the definition and elements with a larger, international group of practising nurses and service users.Relevance to clinical practiceThe definition and elements, through ongoing refinement, will contribute to a robust evidence base that will underpin policy development and the systematic and effective teaching, delivery, measurement and evaluation of fundamental care.
Clinical factors associated with physician choice of femoral versus radial access: A real‐world experience from a single academic center
Authors: Yee Jimmy , Kumar Vishesh , Li Shenjing , Petraskova Terezia , Pham Alex , Stys Julia , Thompson Paul. A , Petrasko Marian , Stys Adam , Stys Tomasz 
Published: December 2017

ObjectivesTo analyze clinical factors associated with operator's preference in selection of femoral versus radial access for angiography and percutaneous intervention (PCI) procedures.BackgroundThere has been an increase in radial access in cardiac catheterization and PCI in the last few decades.MethodsData from 11 226 consecutive cardiac catheterization procedures were collected from Sanford University Medical Center (University of South Dakota, Sanford School of Medicine) from 2011 to 2015.ResultsIn the overall cases, clinical factors that favored upfront femoral access include patients presenting as ST‐elevation myocardial infarction (STEMI) or emergent, coronary artery bypass graft, body mass index (BMI) <30 kg/m2 and age ≥70 years, whereas morbidly obese patients (BMI ≥35) and age <70 favored upfront radial access. Radial access in the overall group had lower fluoroscopy time (6.5 vs 8.4 min, P < 0.0001) and lower contrast use (68.8 vs 80.6 cc, P < 0.0001). In the PCI group, efficacy of upfront radial access is less evident with radial fluoroscopy time (10.1 vs 11.0 min, P < 0.0028) and contrast use being higher in radial group (113.8 vs 108.2 cc, P < 0.037). Interventional cardiologists were more efficient in diagnostic cases than non‐interventional cardiologists.ConclusionSTEMI or emergent cases and elderly patients favor upfront femoral access. As BMI increases and age decreases, radial access is progressively favored. In diagnostic cases, radial access appears to be superior to femoral access in efficacy, but the distinction is less obvious in PCI and STEMI or emergent cases.
Neuroimaging of Dilated Perivascular Spaces: From Benign and Pathologic Causes to Mimics
Authors: Rudie Jeffrey D. , Rauschecker Andreas M. , Nabavizadeh Seyed A. , Mohan Suyash 
Published: December 2017

ABSTRACTPerivascular spaces (PVSs), also known as Virchow‐Robin spaces, are pial‐lined, fluid‐filled structures found in characteristic locations throughout the brain. They can become abnormally enlarged or dilated and in rare cases can cause hydrocephalus. Dilated PVSs can pose a diagnostic dilemma for radiologists because of their varied appearance, sometimes mimicking more serious entities such as cystic neoplasms, including dysembryoplastic neuroepithelial tumor and multinodular and vacuolating neuronal tumor, or cystic infections including toxoplasmosis and neurocysticercosis. In addition, various pathologic processes, including cryptococcosis and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, can spread into the brain via PVSs, resulting in characteristic magnetic resonance imaging appearances. This review aims to describe the key imaging characteristics of normal and dilated PVSs, as well as cystic mimics and pathologic processes that directly involve PVSs.
Comparison of the outcomes of dynamic/static tests and palpation tests in TMD‐pain patients
Authors: Osiewicz M.A. , Manfredini D. , Loster B.W. , van Selms M.K.A. , Lobbezoo F. 
Published: December 2017

SummaryIn addition to palpation tests, dynamic/static tests have been proposed to complement temporomandibular disorders (TMD) patients’ evaluation in the clinical setting. The aim of this study was to assess the intra‐ and inter‐observer reliability of the palpation tests and of the dynamic/static tests, and to determine whether those tests would yield comparable outcomes in terms of pain diagnoses. Ninety‐eight (N = 98) consecutive adult patients were examined during 2 clinical sessions by 2 independent examiners, based on muscle and joint palpation techniques described in the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). They also underwent dynamic/static tests. The intra‐observer reliability of palpation tests was generally poor, with fair‐to‐good to excellent ICC values only for the superior masseter and intra‐oral sites. The inter‐observer reliability of palpation was fair‐to‐good for muscles, but it was poor for the TMJ lateral pole. Both intra‐ and inter‐observer reliability for the dynamic/static tests varied from fair‐to‐good to excellent. The intra‐observer reliability for muscle pain diagnoses based on palpation tests was between poor and fair‐to‐good, whereas the inter‐observer reliability was excellent. The intra‐observer reliability for pain diagnoses based on dynamic/static tests was fair‐to‐good, and the inter‐observer reliability varied from fair‐to‐good to excellent. Conclusions: Some features of the dynamic/static tests make them potentially more useful than palpation tests for selected clinical purposes, such as discriminating between joint and muscle pain as well as monitoring symptoms course. Thus, findings from this investigation suggest that both tests should be included in the TMD diagnostic algorithms.
Early initiated feeding versus early reached target enteral nutrition in critically ill children: An observational study in paediatric intensive care units in Turkey
Authors: Baǧci Soyhan , Keleş Elif , Girgin Feyza , Yıldızdaş Dinçer R , Horoz Özden Ö , Yalındağ Nilüfer , Tanyıldız Murat , Bayrakçi Benan , Kalkan Gökhan , Akyıldız Başak N , Köker Alper , Köroğlu Tolga , Anıl Ayşe B , Zengin Neslihan , Dinleyici Ener Ç , Kıral Eylem , Dursun Oğuz , Yavuz Süleyman Tolga , Bartmann Peter , Müller Andreas 
Published: December 2017

AimAlthough early enteral nutrition (EN) is strongly associated with lower mortality in critically ill children, there is no consensus on the definition of early EN. The aim of this study was to evaluate our current practice supplying EN and to identify factors that affect both the initiation of feeding within 24 h after paediatric intensive care unit (PICU) admission and the adequate supply of EN in the first 48 h after PICU admission in critically ill children.MethodsWe conducted a prospective, multicentre, observational study in nine PICUs in Turkey. Any kind of tube feeding commenced within 24 h of PICU admission was considered early initiated feeding (EIF). Patients who received more than 25% of the estimated energy requirement via enteral feeding within 48 h of PICU admission were considered to have early reached target EN (ERTEN).ResultsFeeding was initiated in 47.4% of patients within 24 h after PICU admission. In many patients, initiation of feeding seems to have been delayed without an evidence‐based reason. ERTEN was achieved in 43 (45.3%) of 95 patients. Patients with EIF were significantly more likely to reach ERTEN. ERTEN was an independent significant predictor of mortality (P < 0.001), along with reached target enteral caloric intake on day 2 associated with decreased mortality.ConclusionsThere is a substantial variability among clinicians' perceptions regarding indications for delay to initiate enteral feeding in critically ill children, especially after the first 6 h of PICU admission. ERTEN, but not EIF, is associated with a significantly lower mortality rate in critically ill children.
Sevelamer hydrochloride suppresses proliferation of parathyroid cells during the early phase of chronic renal failure in rats
Authors: Xiao Xiao , Liu Yan , Zhong Xiaoshi , Liu Yun , Zhou Daoyuan , Xiong Xuan , Ran Jianmin 
Published: December 2017

ABSTRACTAimWe examined the effects of sevelamer on parathyroid cell proliferation and secondary hyperparathyroidism in rats following induction of early‐phase of chronic renal failure (CRF) by unilateral ureteral obstruction (UUO).MethodsFor 5 days, rats in the control group received normal food, rats in the sevelamer group (SH) received control food plus 5% sevelamer, and rats in the low protein group (LP) received low protein food. Five rats of each group were killed at baseline (day 0). All other rats were given UUO, and five rats per group were killed on days 3, 7, 14, and 28 after UUO. Changes in body weight, serum phosphorus, calcium, intact‐parathyroid hormone (i‐PTH), creatinine (SCr), creatinine clearance rate (CCR), blood urea nitrogen (BUN), and 24‐h urinary phosphorus were determined. Parathyroid tissues were removed for histological examination of proliferating cell nuclear antigen‐positive (PCNA+) cells.ResultsMeasurement of body weight, BUN, and SCr in the controls indicated successful establishment of this model of early‐phase CRF. The controls also had remarkable proliferation of PCNA+ cells beginning on day 3, but this did not occur in the SH or LP groups. After 28 days, serum phosphorus had decreased more in the SH and LP groups than in the control group, and phosphorus excretion was much greater in the control group than in the SH and LP groups. The three groups had similar increases in serum i‐PTH.ConclusionSevelamer rapidly lowered the serum phosphorus and inhibited the proliferation of PCNA+ cells in this experimental model of early‐phase CRF.