bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correction of Femoral Valgus Deformity
Authors: Brinkman Justus-Martijn , Pronk Yvette , van Heerwaarden Ronald 
Published: May 2017

AbstractIn the past two decades, the insights in the causes and development of valgus leg deformities as well as the options for treatment with corrective osteotomies have dramatically changed. New definitions for deformity analysis and planning for corrections have better defined the patients suitable for femoral valgus deformity corrections. Biomechanical research on new osteotomy methods and stability of plate fixation have provided scientific background for the development of improved surgical techniques that are more accurate, safer, and provide for quicker rehabilitation and bone healing. This article provides an overview of the basic principles behind the correction of femoral valgus deformity. Both the analysis and planning of femoral valgus deformity correction as well as the results of systematic clinical reviews are provided. The current recommended surgical technique of biplanar medial closing-wedge supracondylar osteotomy is explained, and the first clinical results are reported. Finally, the authors describe some of the future directions and needs for treatment optimization of patients with femoral valgus deformity.
Osteoglophonic Dysplasia: Phenotypic and Radiological Clues
Authors: Kuthiroly Shwetha , Yesodharan Dhanya , Ghosh Aneesh , White Kenneth , Nampoothiri Sheela 
Published: May 2017

AbstractOsteoglophonic dysplasia (OD) is an extremely rare, skeletal dysplasia with an autosomal dominant mode of inheritance. Rhizomelic dwarfism, craniosynostosis, impacted teeth, hypodontia or anodontia, and multiple nonossifying bone lesions are the salient features of this condition. We report a 14-year-old girl with clinical and radiological features consistent with OD. She presented with disproportionate short stature, craniosynostosis, a prominent supraorbital ridge, delayed teeth eruption, hypodontia, and multiple nonossifying bone lesions in the femur, tibia, and fibula. She had hypophosphatemia, which is a known association in this dysplasia. She also had advanced bone age, which is an unreported feature of this dysplasia. This condition is caused by activating mutations in FGFR1. A missense mutation was detected in the FGFR1, NM_001174067 (FGFR1_v001):c.1115G > A [p.(Cys372Tyr)] confirming the diagnosis; this is the first mutation-proven case to be reported from India.
An agentive non-intentionalist theory of self-deception
Authors: Lynch Kevin 
Published: May 2017

AbstractThe self-deception debate often appears polarized between those who think that self-deceivers intentionally deceive themselves (‘intentionalists’), and those who think that intentional actions are not significantly involved in the production of self-deceptive beliefs at all. In this paper I develop a middle position between these views, according to which self-deceivers do end up self-deceived as a result of their own intentional actions, but where the intention these actions are done with is not an intention to deceive oneself. This account thus keeps agency at the heart of self-deception, while also avoiding the paradox associated with other agency-centered views.
Financial Incentives for Adherence to Hepatitis C Virus Clinical Care and Treatment: A Randomized Trial of Two Strategies
Authors: Wohl David A. , Allmon Andrew G. , Evon Donna , Hurt Christopher , Reifeis Sarah Ailleen , Thirumurthy Harsha , Straub Becky , Edwards Angela , Mollan Katie R. 
Published: May 2017

Abstract

Background
Although rates of sustained virologic response (SVR) after hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) surpass 90% in trials and some more “real world” settings, some patients, such as those with substance use disorders, will be challenged to adhere to HCV care.

Methods
To assess the feasibility of 2 strategies for financially incentivizing adherence to HCV care, patients with a substance use history prescribed 12 weeks of a sofosbuvir-containing regimen were randomized to either fixed or lottery-based monetary incentives for attending clinic appointments, pill count adherence &gt;90%, and SVR achievement. Electronic medication monitoring provided an objective measure of DAA adherence.

Results
Fifty-nine participants were randomized to the lottery (n = 31) or fixed-incentive (n = 28) arms. All 31 (100%) in the lottery arm and 24 of 28 (86%) in the fixed arm completed 12 weeks of therapy. By intent-to-treat, 93% in the lottery arm and 92% in the fixed arm achieved SVR (estimated difference: 0.5%; 95% confidence interval, −17.5 to 18.8). Overall, 92% of scheduled visits were attended without significant differences between arms. The mean adherence ratio (days with ≥1 bottle opening:monitored days) was 0.91 for lottery and 0.92 for fixed arms.

Conclusions
In this pilot, fixed- and lottery-based financial incentives were successfully implemented and accepted by patients with a substance use history. High levels of HCV therapy and care adherence, as well as rates of SVR, were observed. Financial incentives may be useful to support treatment adherence in patients with substance use disorders and should be tested in a larger, randomized, controlled trial.
Contribution of Endocannabinoid Gene Expression and Genotype on Low Back Pain Susceptibility and Chronicity
Authors: Ramesh Divya , D’Agata Amy , Starkweather Angela R. , Young Erin E. 
Published: May 2017

Background:
A major research emphasis has been focused on defining the molecular changes that occur from acute to chronic pain to identify potential therapeutic targets for chronic pain. As the endocannabinoid system is dynamically involved in pain signaling, a plausible mechanism that may contribute to chronic pain vulnerability involves alterations in the amount of circulating endocannabinoids. Therefore, this study sought to examine cannabinoid type 1 (CNR1), type 2 (CNR2) receptors, fatty acid amide hydrolase (FAAH), and the vanilloid receptor (transient receptor potential cation channel subfamily V member 1 [TRPV1]) gene expression profiles among individuals with acute and chronic low back pain (cLBP) at their baseline visit. We also assessed associations among selected single nucleotide polymorphisms (SNPs) of FAAH and CNR2 and measures of somatosensory function and self-report pain measures.

Method:
Using a previously established quantitative sensory testing protocol, we comprehensively assessed somatosensory parameters among 42 acute LBP, 42 cLBP, and 20 pain-free participants. Samples of whole blood were drawn to examine mRNA expression and isolate genomic DNA for genotyping.

Results:

CNR2 mRNA was significantly upregulated in all LBP patients compared with controls. However, FAAH mRNA and TRPV1 mRNA were significantly upregulated in cLBP compared with controls. A significant association was observed between FAAH SNP genotype and self-report pain measures, mechanical and cold pain sensitivity among LBP participants. cLBP participants showed increased FAAH and TRPV1 mRNA expression compared with acute LBP patients and controls.

Conclusions:
Further research to characterize pain-associated somatosensory changes in the context of altered mRNA expression levels and SNP associations may provide insight on the molecular underpinnings of maladaptive chronic pain.
Recurrent Cutaneous Angiosarcoma of the Scalp With Aberrant Expression of S100: A Case Report
Authors: Macías-García Laura , Lara-Bohorquez Concepción , Jorquera-Barquero Enrique , Ríos-Martín Juan J. 
Published: May 2017

Abstract:
Angiosarcoma (AS) is a malignant mesenchymal neoplasm of endothelial origin with a predominantly lymphatic immunophenotype, which accounts for less than 1% of all sarcomas. Cutaneous AS of the scalp is associated with high rates of local recurrence and a poor prognosis. Histologically, poorly differentiated AS often comprises solid epithelioid cells, although rare variants involving spindle cells have been reported; diagnosis requires immunohistochemical analysis using vascular cell markers. We report on a cutaneous spindle-cell AS of the scalp in a female patient; key features included spontaneous regression after biopsy, local recurrence 2 years later, and aberrant nuclear staining for S100 protein in an area of the tumor not expressing CD34 or D2-40. Tumor cells exhibited positivity for vascular markers CD31, CD34, D2-40, ERG and FLI-1 and were negative for myoid markers (αSMA and desmin), epithelial (EMA and cytokeratin AE1/AE3) and melanocyte markers (HMB45 and melan-A). Cutaneous spindle-cell AS of the scalp is a rare variant with a poor prognosis. Diagnosis of spindle-cell AS was confirmed by immunohistochemical analysis using CD31, CD34, ERG, FLI-1, podoplanin (D2-40), and claudin-5. Although a number of authors have noted aberrant expression of cytokeratins, CD30, CD117 and neuroendocrine markers (synaptophysin and chromogranin A) in AS, intense positive nuclear staining for S100 protein in neoplastic cells has not hitherto been observed. This article reports on a spindle-cell AS of the scalp notable for aberrant expression of S100, spontaneous regression and recurrence 2 years later at the same site and displaying identical histological and immunohistochemical features.
Genomic Assessment of Blitz Nevi Suggests Classification as a Subset of Blue Nevus Rather Than Spitz Nevus: Clinical, Histopathologic, and Molecular Analysis of 18 Cases
Authors: Isales Maria C. , Haugh Alexandra M. , Bubley Jeffrey , Verzì Anna E. , Zhang Bin , Kudalkar Emily , Lee Christina Y. , Yazdan Pedram , Guitart Joan , Gerami Pedram 
Published: May 2017

Abstract:
Blitz nevi/tumors are a distinct subset of melanocytic neoplasia which show mixed morphologic features of Spitz and blue nevus. Genomically, most blue nevi have GNAQ or GNA11 mutations while most Spitzoid neoplasms have either an HRAS mutation or translocations involving MET, ROS, BRAF, ALK1, NTRK1, and RET. The criteria used for the assessment of malignancy in blue and Spitzoid lesions are different, and these lesions have different prognostic markers. In this study, we assess the clinical, morphological, and genomic changes in 18 cases of Blitz nevi/tumors to better characterize this subset of neoplasms and determine their optimal genomic classification. Most lesions occurred on the extremities followed by the head and neck region typical of blue nevi. Histology showed most cases having a prominent plexiform growth pattern with cells aggregating around the adnexal structures and neurovascular bundles also typical of blue nevi. Using next generation sequencing, we detected the presence of somatic mutations in GNAQ or GNA11 in 4 of 7 cases (57%) of Blitz nevi with sufficient DNA available for sequencing. Normal skin samples in these 4 cases were sequenced to confirm that the GNAQ or GNA11 mutations were somatic mutations. All 4 cases were negative for immunohistochemical assessment for wild-type BRAF, RET, ALK, and NTRK1 and mutational analysis of HRAS was also negative in all cases. Hence, our study suggests that Blitz nevi/tumors are a distinct subset which genomically are best classified as a subset of blue nevi.
Sustained Viral Suppression in HIV-infected Children on Once-daily Lopinavir/Ritonavir in Clinical Practice
Authors: Gondrie Ivar P. E. , Bastiaans Diane E. T. , Fraaij Pieter L. A. , Driessen Gertjan J. A. , van der Knaap Linda C. , Visser Eline G. , van Jaarsveld Petronette , de Groot Ronald , Hartwig Nico G. , Burger David M. , van Rossum Annemarie M. C. 
Published: May 2017

Background:
The use of lopinavir/ritonavir once-daily (LPV/r QD) has not been approved for children. Good short-term clinical, virologic and immunologic outcomes have been observed in children on LPV/r QD.

Methods:
We evaluated the long-term effectiveness of a LPV/r QD containing regimen in HIV-1–infected children in clinical practice. Selected children (0–18 years of age) with an undetectable HIV-1 RNA viral load (<50 copies/mL) for at least 6 months on a twice-daily LPV/r-containing regimen switched to LPV/r QD. The main outcome measures were the percentage of patients with an undetectable HIV-1 viral load each subsequent year after switch to LPV/r QD (on treatment and last observation carried forward), and virologic failure during follow-up (>400 copies/mL twice within 6 months). Also, the exposure to LPV on the initial once-daily dosing regimen was determined.

Results:
Forty children (median age: 6.5 years; range: 1.0–17) were included. Median follow-up was 6.3 years (range: 1.0–10.3). During yearly follow-up, the percentage of children with an undetectable viral load varied between 82% and 100% (on treatment) and 83% and 93% (last observation carried forward). Five children (12.5%) met the criteria for failure. CD4+ and CD8+ counts remained stable at normal values. Geometric mean LPV area under the plasma concentration-time curve (linear up-log down method) over a dosing interval from time 0 to 24 hours after dosing was 169.3 mg x h/L, and last observed drug concentration was 1.35 mg/L. Adverse events were encountered in 8 patients, were mainly gastrointestinal, and in these cases, no reason to stop treatment.

Conclusion:
A once-daily LPV/r-containing regimen in HIV-1–infected children with intensive clinical and therapeutic drug monitoring is well tolerated and has good long-term clinical, virologic and immunologic outcomes.
In-Plane Ultrasound-Guided Knee Injection Through a Lateral Suprapatellar Approach
Authors: Chagas-Neto Francisco A. , Taneja Atul K. , Gregio-Junior Everaldo , Nogueira-Barbosa Marcello H. 
Published: May 2017

Purpose
This study aims to describe a technique for in-plane ultrasound-guided knee arthrography through a lateral suprapatellar approach, reporting its accuracy and related complications.

Methods
A retrospective search was performed for computed tomography and magnetic resonance reports from June 2013 through June 2015. Imaging studies, puncture descriptions, and guided-procedure images were reviewed along with clinical and surgical history. A fellowship-trained musculoskeletal radiologist performed all procedures under sterile technique and ultrasound guidance with the probe in oblique position on the lateral suprapatellar recess after local anesthesia with the patient on dorsal decubitus, hip in neutral rotation, and 30 to 45 degrees of knee flexion.

Results
A total of 86 consecutive subjects were evaluated (mean, 55 years). All subjects underwent intra-articular injection of contrast, which was successfully reached in the first attempt in 94.2% of the procedures (81/86), and in the second attempt in 5.8% (5/86) after needle repositioning without a second puncture. There were no postprocedural reports of regional complications at the puncture site, such as significant pain, bleeding, or vascular lesions.

Conclusions
Our study demonstrates that in-plane ultrasound-guided injection of the knee in semiflexion approaching the lateral suprapatellar recess is a safe and useful technique to administer intra-articular contrast solution, as an alternative method without radiation exposure.
Multilevel and sex-specific selection on competitive traits in North American red squirrels
Authors: Fisher David N. , Boutin Stan , Dantzer Ben , Humphries Murray M. , Lane Jeffrey E. , McAdam Andrew G. 
Published: May 2017

AbstractIndividuals often interact more closely with some members of the population (e.g. offspring, siblings or group members) than they do with other individuals. This structuring of interactions can lead to multilevel natural selection, where traits expressed at the group-level influence fitness alongside individual-level traits. Such multilevel selection can alter evolutionary trajectories, yet is rarely quantified in the wild, especially for species that do not interact in clearly demarcated groups. We quantified multilevel natural selection on two traits, postnatal growth rate and birth date, in a population of North American red squirrels (Tamiasciurus hudsonicus). The strongest level of selection was typically within-acoustic social neighbourhoods (within 130m of the nest), where growing faster and being born earlier than nearby litters was key, while selection on growth rate was also apparent both within-litters and within-study areas. Higher population densities increased the strength of selection for earlier breeding, but did not influence selection on growth rates. Females experienced especially strong selection on growth rate at the within-litter level, possibly linked to the biased bequeathal of the maternal territory to daughters. Our results demonstrate the importance of considering multilevel and sex-specific selection in wild species, including those that are territorial and sexually monomorphic.Data archival: the data set is archived on Dryad (info XXX), with a five-year embargo from the date of publication.
Decoding Human Emotional Faces in the Dog’s Brain
Authors: Hernández-Pérez Raúl , Concha Luis , Cuaya Laura V. 
Published: May 2017

AbstractDogs can interpret emotional human faces (especially the ones expressing happiness), yet the cerebral correlates of this process are unknown. Using functional magnetic resonance imaging (fMRI) we studied eight awake and unrestrained dogs. In Experiment 1 dogs observed happy and neutral human faces, and found increased brain activity when viewing happy human faces in temporal cortex and caudate. In Experiment 2 the dogs were presented with human faces expressing happiness, anger, fear, or sadness. Using the resulting cluster from Experiment 1 we trained a linear support vector machine classifier to discriminate between pairs of emotions and found that it could only discriminate between happiness and the other emotions. Finally, evaluation of the whole-brain fMRI time courses through a similar classifier allowed us to predict the emotion being observed by the dogs. Our results show that human emotions are specifically represented in dogs’ brains, highlighting their importance for inter-species communication.
Partitioning the roles of insect and microbial enzymes in the metabolism of the insecticide imidacloprid inDrosophila melanogaster
Authors: Fusetto Roberto , Denecke Shane , Perry Trent , O’Hair Richard A. J. , Batterham Philip 
Published: May 2017

AbstractResistance to insecticides through enhanced metabolism is a worldwide problem. TheCyp6g1gene of the vinegar fly,Drosophila melanogaster, is a paradigm for the study of metabolic resistance. Constitutive overexpression of this gene confers resistance to several chemical classes of insecticides, including the neonicotinoids exemplified by the insecticide imidacloprid (IMI). The metabolism of IMI in this species has been previously shown to yield oxidative and nitro-reduced metabolites. While levels of the oxidative metabolites are correlated with CYP6G1 expression, nitro-reduced metabolites are not, raising the question of how these metabolites are produced. Some IMI metabolites are known to be toxic, making their fate within the insect a second question of interest. These questions have been addressed by coupling the genetic tools of gene overexpression and CRISPR gene knock-out with the sensitive mass spectrometric technique, the Twin-Ion Method (TIM). Analysing axenic larvae indicated that microbes living withinD. melanogasterare largely responsible for the production of the nitro-reduced metabolites. Knock-out ofCyp6g1revealed functional redundancy, with some metabolites produced by CYP6G1 still detected. IMI metabolism was shown to produce toxic products that are not further metabolized but readily excreted, even when produced in the Central Nervous System (CNS), highlighting the significance of transport and excretion in metabolic resistance.
Coessentiality and cofunctionality: a network approach to learning genetic vulnerabilities from cancer cell line fitness screens
Authors: Hart Traver , Koh Clara , Moffat Jason 
Published: May 2017

AbstractGenetic interaction networks are a powerful approach for functional genomics, and the synthetic lethal interactions that comprise these networks offer a compelling strategy for identifying candidate cancer targets. As the number of published shRNA and CRISPR perturbation screens in cancer cell lines expands, there is an opportunity for integrative analysis that goes further than pairwise synthetic lethality and discovers genetic vulnerabilities of related sets of cell lines. We re-analyze over 100 high-quality, genome-scale shRNA screens in human cancer cell lines and derive a quantitative fitness score for each gene that accurately reflects genotype-specific gene essentiality. We identify pairs of genes with correlated essentiality profiles and merge them into a cancer coessentiality network, where shared patterns of genetic vulnerability in cell lines give rise to clusters of functionally related genes in the network. Network clustering discriminates among all three defined subtypes of breast cancer cell lines (basal, luminal, and Her2-amplified), and further identifies novel subsets of Her2+ and ovarian cancer cells. We demonstrate the utility of the network as a platform for both hypothesis-driven and data-driven discovery of context-specific essential genes and their associated biomarkers.
Guardianship and supported decision making in Israel
Authors: Davies Rebecca Naomi , Werner Shirli , Sinai Amanda 
Published: May 2017

Purpose
Recent research has promoted the use of supported decision making, in contrast to historical methods of substitute decision making when working with people with intellectual disabilities. In Israel, people with disabilities are protected by the Legal Capacity and Guardianship Law of 1962, which was amended in 2016. The purpose of this paper is to consider how these recent changes are perceived by the professionals in Israel.

Design/methodology/approach
Professionals with experience in policy making, law, social work and with direct experience working with people with intellectual disabilities (ID) were interviewed using semi-structured interviews and one focus group. Interviews were recorded and subsequently coded and analysed qualitatively.

Findings
Two major themes were identified. These were: the law and its phrasing, and changing culture. Findings highlight the process of change within guardianship law and practice and the challenges in implementation encountered so far and anticipated in the future.

Originality/value
Guardianship laws are changing in many states and the challenges to implementation of supported decision-making in these countries have been echoed in this study. Functional models to allow implementation of supported decision-making have not yet been strongly evidenced. It is hoped that this research may provide a springboard for further study into legal capacity and guardianship issues in Israel and elsewhere.