bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modifiable factors associated with patient-reported pain during and after screening colonoscopy
Authors: Bugajski Marek , Wieszczy Paulina , Hoff Geir , Rupinski Maciej , Regula Jaroslaw , Kaminski Michal Filip 
Published: October 2017

ObjectivePain associated with colonoscopy is a major burden for patients. We investigated modifiable factors associated with patient-reported pain during and after colonoscopy.DesignThis cross-sectional analysis included database records from 23 centres participating in a population-based colonoscopy screening programme in Poland. Colonoscopies were performed under three sedation modalities: none, benzodiazepine-opioid sedation or propofol sedation. We used Gastronet (a validated tool) to assess patients’ pain during and after colonoscopy; pain was scored on a four-point scale (no, little, moderate or severe pain), with moderate to severe defined as painful. We used multivariate logistic regression models to estimate ORs for painful colonoscopy and calculated risk-adjusted ratios of painful colonoscopies per endoscopist and compared it to the mean rate.ResultsOf 35 216 screening colonoscopies in 2014 and 2015 included in our study, 22 725 (64.5%) patients returned valid Gastronet questionnaires. The proportion of examinations described as causing pain during (after) the procedure was 22.5% (14.2%) for unsedated, 19.9% (13.5%) for benzodiazepine-opioid sedation and 2.5% (7.5%) for propofol sedation. Propofol sedation, higher case volume of endoscopists, newest endoscope generation and adequate bowel preparation were significantly associated with lower odds of painful colonoscopy. Pain scores after colonoscopy showed similar associations. Adjusted pain rates during and after colonoscopy varied 11 and over 23-fold, respectively, between endoscopists.ConclusionWe identified several independent, modifiable factors associated with pain during and after colonoscopy, of which individual endoscopist was the most important. Dedicated training should be considered to decrease variability among endoscopists.
Health system and law enforcement synergies for injury surveillance, control and prevention: a scoping review
Authors: Jacoby Sara F , Kollar Laura M Mercer , Ridgeway Greg , Sumner Steven A 
Published: October 2017

BackgroundHealthcare providers and law enforcement (LE) officers are among the most common first responders to injuring events. Despite frequent interface between the health system (HS) and LE sectors, the published evidence that supports their collaboration in injury surveillance, control and prevention has not been comprehensively reviewed.MethodsWe conducted a scoping review of literature published from 1990 to 2016 that focused on local and regional HS and LE collaborations in injury surveillance, control and prevention. Our aim was to describe what is known and what remains unexplored about these cross-sector efforts.Results128 articles were included in the final review. These were categorised by their focus on either surveillance activities or partnerships in injury control and prevention programmes. The majority of surveillance articles focused on road traffic injuries. Conversely, articles describing partnerships and programme evaluations primarily targeted the prevention of interpersonal violence.DiscussionThis review yielded two major findings: overall, the combination of HS and LE injury data added value to surveillance systems, especially as HS data augmented LE data; and HS and LE partnerships have been developed to improve injury control and prevention. However, there are few studies that have evaluated the impact and sustainability of these partnerships.ConclusionsThe current evidence to support HS and LE collaboration in injury surveillance and control and prevention programmes is heterogeneous. Notable gaps suggest ample opportunity for further research and programme evaluation across all types of injury.
Coeliac disease and the liver: spectrum of liver histology, serology and treatment response at a tertiary referral centre
Authors: Majumdar Kaushik , Sakhuja Puja , Puri Amarender Singh , Gaur Kavita , Haider Aiman , Gondal Ranjana 
Published: October 2017

BackgroundCoeliac disease (CD) is a gluten-sensitive enteropathy diagnosed on the basis of ESPGHAN criteria and clinical response to gluten-free diet (GFD). Histological abnormalities on liver biopsy have been noted in CD but have seldom been described.AimsTo assess the histological spectrum of ‘coeliac hepatitis’ and possibility of reversal of such features after a GFD.MethodsTwenty-five patients with concomitant CD and hepatic derangement were analysed for clinical profile, laboratory investigations and duodenal and liver biopsy. A histological comparison of pre- and post-GFD duodenal and liver biopsies was carried out, wherever possible.ResultsFifteen patients presenting with CD subsequently developed abnormal liver function tests; 10 patients presenting with liver disease were found to have tissue positive transglutaminase in 70% and antigliadin antibodies in 60%. Serological markers for autoimmune liver disease (AILD) were positive in eight patients. Liver histology ranged from mild reactive hepatitis, chronic hepatitis, steatosis to cirrhosis. Liver biopsies after a GFD were available in six cases, of which five showed a decrease in steatosis, portal and lobular inflammation and fibrosis score.ConclusionCoeliac hepatitis could be a distinct entity and the patients may present with either CD or secondary hepatic derangement. Evaluation for the presence of CD is recommended for patients presenting with AILD, unexplained transaminasaemia or anaemia. This is one of the very few studies demonstrating the continuum of liver histological changes in ‘coeliac hepatitis’. Trial of a GFD may result in clinicopathological improvement of ‘coeliac hepatitis’.
Infectious and non-infectious complications in primary immunodeficiency disorders: an autopsy study from North India
Authors: Gupta Kirti , Rawat Amit , Agrawal Parimal , Jindal Ankur , Nada Ritambhra , Saikia Biman , Chan Koon Wing , Lau Yu Lung , Minz Ranjana Walker , Singh Surjit 
Published: October 2017

BackgroundPrimary immunodeficiency disorders (PID) include a wide spectrum of inherited disorders characterised by functional abnormalities of one or more components of the immune system. Recent updates from the genomic data have contributed significantly to its better understanding with identification of new entities. Diagnosis is always challenging due to their variable clinical presentation. With the evolution of molecular diagnosis, many of these children are being diagnosed early and offered appropriate therapy. However, in developing countries, early diagnosis is still not being made: as a result these patients succumb to their disease. Autopsy data on PID is notably lacking in the literature with histopathological evaluation of PID being limited to rare case reports.ObjectiveTo analyse the clinical, immunologic (including mutational) and morphologic features at autopsy in 10 proven and suspected cases of primary immunodeficiency disorders diagnosed at our Institute over the past decade.MethodsStudy includes a detailed clinico-pathological analysis of 10 proven and suspected cases of primary immunodeficiency disorders.ResultsA varied spectrum of infectious and non-infectious complications were identified in these cases of which fungal infections were found to be more frequent compared with viral or bacterial infections. Rare and novel morphological findings, like granulomatous involvement of the heart in a patient with chronic granulomatous disease, systemic amyloidosis in a teenage girl with X-linked agammaglobulinemia, are highlighted which is distinctly lacking in the literature.ConclusionsThe present study is perhaps the first autopsy series on PID. Even in the molecular era, such analysis is still important, as correlation of pathological features with clinical symptoms provides clues for a timely diagnosis and appropriate therapeutic intervention.
Understanding bias in relationships between the food environment and diet quality: the Coronary Artery Risk Development in Young Adults (CARDIA) study
Authors: Rummo Pasquale E , Guilkey David K , Ng Shu Wen , Meyer Katie A , Popkin Barry M , Reis Jared P , Shikany James M , Gordon-Larsen Penny 
Published: October 2017

BackgroundThe relationship between food environment exposures and diet behaviours is unclear, possibly because the majority of studies ignore potential residual confounding.MethodsWe used 20 years (1985–1986, 1992–1993 2005–2006) of data from the Coronary Artery Risk Development in Young Adults (CARDIA) study across four US cities (Birmingham, Alabama; Chicago, Illinois; Minneapolis, Minnesota; Oakland, California) and instrumental variables (IV) regression to obtain causal estimates of longitudinal associations between the percentage of neighbourhood food outlets (per total food outlets within 1 km network distance of respondent residence) and ana prioridiet quality score, with higher scores indicating higher diet quality. To assess the presence and magnitude of bias related to residual confounding, we compared results from causal models (IV regression) to non-causal models, including ordinary least squares regression, which does not account for residual confounding at all and fixed-effects regression, which only controls for time-invariant unmeasured characteristics.ResultsThe mean diet quality score across follow-up was 63.4 (SD=12.7). A 10% increase in fast food restaurants (relative to full-service restaurants) was associated with a lower diet quality score over time using IV regression (β=−1.01, 95% CI −1.99 to –0.04); estimates were attenuated using non-causal models. The percentage of neighbourhood convenience and grocery stores (relative to supermarkets) was not associated with diet quality in any model, but estimates from non-causal models were similarly attenuated compared with causal models.ConclusionIgnoring residual confounding may generate biased estimated effects of neighbourhood food outlets on diet outcomes and may have contributed to weak findings in the food environment literature.
Potential deaths averted in USA by replacing cigarettes with e-cigarettes
Authors: Levy David T , Borland Ron , Lindblom Eric N , Goniewicz Maciej L , Meza Rafael , Holford Theodore R , Yuan Zhe , Luo Yuying , O’Connor Richard J , Niaura Raymond , Abrams David B 
Published: October 2017

IntroductionUS tobacco control policies to reduce cigarette use have been effective, but their impact has been relatively slow. This study considers a strategy of switching cigarette smokers to e-cigarette use (‘vaping’) in the USA to accelerate tobacco control progress.MethodsA Status Quo Scenario, developed to project smoking rates and health outcomes in the absence of vaping, is compared with Substitution models, whereby cigarette use is largely replaced by vaping over a 10-year period. We test an Optimistic and a Pessimistic Scenario, differing in terms of the relative harms of e-cigarettes compared with cigarettes and the impact on overall initiation, cessation and switching. Projected mortality outcomes by age and sex under the Status Quo and E-Cigarette Substitution Scenarios are compared from 2016 to 2100 to determine public health impacts.FindingsCompared with the Status Quo, replacement of cigarette by e-cigarette use over a 10-year period yields 6.6 million fewer premature deaths with 86.7 million fewer life years lost in the Optimistic Scenario. Under the Pessimistic Scenario, 1.6 million premature deaths are averted with 20.8 million fewer life years lost. The largest gains are among younger cohorts, with a 0.5 gain in average life expectancy projected for the age 15 years cohort in 2016.ConclusionsThe tobacco control community has been divided regarding the role of e-cigarettes in tobacco control. Our projections show that a strategy of replacing cigarette smoking with vaping would yield substantial life year gains, even under pessimistic assumptions regarding cessation, initiation and relative harm.
Stratigraphy, petrogenesis and geodynamic setting of Late Cretaceous volcanism on the SW margin of the Black Sea, Turkey
Authors: Keskİn Mehmet , Tüysüz Okan 
Published: October 2017

Abstract
The Western Pontide Magmatic Belt consists of two different magmatic series corresponding to two distinct periods of intense volcanism, separated by a pelagic limestone marker horizon resting on a regional unconformity. The first stage of magmatism and associated extensional tectonic regime prevailed in the region between the Middle Turonian and Early Santonian. During the first stage, magmas were derived from a depleted mantle source containing a clear subduction signature. The extrusives intercalated with marine clastic sediments and pelagic carbonates associated with thick debris-flow horizons and olistoliths. Based on geochemistry and depositional features, the first stage is interpreted as an extensional ensialic arc setting developed in response to northwards subduction of the Tethys Ocean beneath the southern margin of Laurasia. During the Late Santonian, the volcanism stopped and the whole region suddenly subsided with the deposition of a thin, but laterally continuous, pelagic limestone horizon. This subsidence may imply the break-up of the Laurasian continental lithosphere and the beginning of oceanic spreading in the Western Black Sea Basin. The intensified extension is interpreted to be linked to the southwards rollback of the subducting slab.
During the second stage in the Campanian, magmas were derived from two contrasting mantle sources: (1) a depleted lithospheric mantle enriched by a subduction component; and (2) an enriched asthenospheric mantle which is similar to that of the ocean island basalts (OIB). The depleted lithospheric source may be linked to the subcontinental lithospheric mantle of Laurasia, which was metasomatized by the previous Tethyan subduction event rather than by an active arc magmatism. Lavas derived from the depleted source are abundant throughout the stratigraphic column, whereas those from the enriched source dominate the end of the second stage. The presence of the alkaline lavas may indicate thinning of the lithosphere and upwelling of the asthenospheric mantle in the matured stages of rifting. We argue that the main cause of both rifting and temporal change in magma generation was the steepening and rollback of the northwards subducting slab of the Tethys Ocean. The aforementioned rollback also caused the Istanbul Zone to be moved to the south, and colliding with the Sakarya Zone in the south during the Maastrichtian. Based on geochemical, stratigraphic, palaeontological and sedimentary data, we suggest that the oceanic Western Black Sea Basin opened as an intra-arc basin during Turonian–Santonian time.
Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors
Authors: Lynch James T. , Polanska Urszula M. , Delpuech Oona , Hancox Urs , Trinidad Antonio G. , Michopoulos Filippos , Lenaghan Carol , McEwen Robert , Bradford James , Polanski Radek , Ellston Rebecca , Avivar-Valderas Alvaro , Pilling James , Staniszewska Anna , Cumberbatch Marie , Critchlow Susan E. , Cruzalegui Francisco , Barry Simon T. 
Published: October 2017

Abstract
Purpose: PTEN-null tumors become dependent on the PI3Kβ isoform and can be targeted by molecules such as the selective PI3Kβ inhibitor AZD8186. However, beyond the modulation of the canonical PI3K pathway, the consequences of inhibiting PI3Kβ are poorly defined.
Experimental Design: To determine the broader impact of AZD8186 in PTEN-null tumors, we performed a genome-wide RNA-seq analysis of PTEN-null triple-negative breast tumor xenografts treated with AZD8186. Mechanistic consequences of AZD8186 treatment were examined across a number of PTEN-null cell lines and tumor models.
Results: AZD8186 treatment resulted in modification of transcript and protein biomarkers associated with cell metabolism. We observed downregulation of cholesterol biosynthesis genes and upregulation of markers associated with metabolic stress. Downregulation of cholesterol biosynthesis proteins, such as HMGCS1, occurred in PTEN-null cell lines and tumor xenografts sensitive to AZD8186. Therapeutic inhibition of PI3Kβ also upregulated PDHK4 and increased PDH phosphorylation, indicative of reduced carbon flux into the TCA cycle. Consistent with this, metabolomic analysis revealed a number of changes in key carbon pathways, nucleotide, and amino acid biosynthesis.
Conclusions: This study identifies novel mechanistic biomarkers of PI3Kβ inhibition in PTEN-null tumors supporting the concept that targeting PI3Kβ may exploit a metabolic dependency that contributes to therapeutic benefit in inducing cell stress. Considering these additional pathways will guide biomarker and combination strategies for this class of agents. Clin Cancer Res; 23(24); 7584–95. ©2017 AACR.
Association between Cigar or Pipe Smoking and Cancer Risk in Men: A Pooled Analysis of Five Cohort Studies
Authors: Malhotra Jyoti , Borron Claire , Freedman Neal D. , Abnet Christian C. , van den Brandt Piet A. , White Emily , Milne Roger L. , Giles Graham G. , Boffetta Paolo 
Published: October 2017

Abstract
Introduction: Use of non-cigarette tobacco products such as cigars and pipe has been increasing, even though these products entail exposure to similar carcinogens to those in cigarettes. More research is needed to explore the risk of these products to guide cancer prevention efforts.
Methods: To measure the association between cigars and/or pipe smoking, and cancer incidence in men, we performed meta-analyses of data from five prospective cohorts. Cox regression was used to evaluate the association between different aspects of cigars and pipe smoking and risk of each smoking-related cancer (head and neck, esophagus, lung, stomach, liver, pancreas, kidney, and bladder) for each study. Adjusted HRs were combined using random-effects models.
Results: Cigars and/or pipe smokers were at increased risk for head and neck [HR, 1.51; 95% confidence interval (CI), 1.22–1.87], lung (HR, 2.04; 95% CI, 1.68–2.47), and liver cancers (HR, 1.56; 95% CI, 1.08–2.26). Ever-smokers of cigars and/or pipe had an increased risk of developing a smoking-related cancer when compared with never smokers of any tobacco product (overall HR, 1.07; 95% CI, 1.03–1.12). The risk for smoking-related cancers was also increased in mixed smokers who smoked cigars or pipe as well as cigarettes, even when they were smoking predominantly pipe or cigars.
Discussion: This pooled analysis highlights the increased risk for smoking-related cancers, particularly for lung and head and neck cancers in exclusive and predominant smokers (former and current) of cigars and pipe. Tobacco prevention efforts should include these products in addition to cigarettes. Cancer Prev Res; 10(12); 704–9. ©2017 AACR.
Differential Gene Regulation and Tumor-Inhibitory Activities of Alpha-, Delta-, and Gamma-Tocopherols in Estrogen-Mediated Mammary Carcinogenesis
Authors: Das Gupta Soumyasri , Patel Misaal , Wahler Joseph , Bak Min Ji , Wall Brian , Lee Mao-Jung , Lin Yong , Shih Weichung Joe , Cai Li , Yang Chung S. , Suh Nanjoo 
Published: October 2017

Abstract
Despite experimental evidence elucidating the antitumor activities of tocopherols, clinical trials with α-tocopherol (α-T) have failed to demonstrate its beneficial effects in cancer prevention. This study compared the chemopreventive efficacy of individual tocopherols (α-, δ-, and γ-T) and a γ-T–rich tocopherol mixture (γ-TmT) in the August-Copenhagen Irish (ACI) rat model of estrogen-mediated mammary cancer. Female ACI rats receiving 17β-estradiol (E2) implants were administered with 0.2% α-T, δ-T, γ-T, or γ-TmT for 30 weeks. Although α-T had no significant effects on mammary tumor growth in ACI rats, δ-T, γ-T, and γ-TmT reduced mammary tumor volume by 51% (P &lt; 0.05), 60% (P &lt; 0.01), and 59% (P &lt; 0.01), respectively. Immunohistochemical analysis revealed that δ-T, γ-T, and γ-TmT reduced levels of the cell proliferation marker, proliferating cell nuclear antigen, in the rat mammary tumors. To gain further insight into the biological functions of different forms of tocopherols, RNA-seq analysis of the tumors was performed. Treatment with γ-T induced robust gene expression changes in the mammary tumors of ACI rats. Ingenuity Pathway Analysis identified “Cancer” as a top disease pathway and “Tumor growth” and “Metastasis” as the top signaling pathways modulated by γ-T. Although the results need further functional validation, this study presents an unbiased attempt to understand the differences between biological activities of individual forms of tocopherols at the whole transcriptome level. In conclusion, δ-T and γ-T have superior cancer preventive properties compared to α-T in the prevention of estrogen-mediated mammary carcinogenesis. Cancer Prev Res; 10(12); 694–703. ©2017 AACR.
Targeting the Noncoding Genome: Superenhancers Meet Their Kryptonite
Authors: Wang Eric , Aifantis Ioannis 
Published: October 2017

Abstract
Summary: In this study, McKeown and colleagues carried out a genome-wide characterization and stratification of the enhancer landscape in acute myeloid leukemia (AML). The authors' analysis led to the discovery of a novel RARA superenhancer found in a subset of patients with AML, rendering these leukemia cells highly sensitive to SY-1425, a highly potent RARA agonist able to induce myeloid differentiation in these high-expressing RARA AML subtypes. Cancer Discov; 7(10); 1065–6. ©2017 AACR.
See related article by McKeown et al., p. 1136.
Diagnosis of Faulty Sensors in Antenna Array using Hybrid Differential Evolution based Compressed Sensing Technique
Authors: Khan Shafqat Ullah , Rahim M. K. A. , Qureshi I. M. , Murad N. A. 
Published: October 2017

<span lang="EN-US">In this work, differential evolution based compressive sensing technique for detection of faulty sensors in linear arrays has been presented. This algorithm starts from taking the linear measurements of the power pattern generated by the array under test. The difference between the collected compressive measurements and measured healthy array field pattern is minimized using a hybrid differential evolution (DE). In the proposed method, the slow convergence of DE based compressed sensing technique is accelerated with the help of parallel coordinate decent algorithm (PCD). The combination of DE with PCD makes the minimization faster and precise. Simulation results validate the performance to detect faulty sensors from a small number of measurements.</span>
Single Channel Speech Enhancement using Wiener Filter and Compressive Sensing
Authors: Sulong Amart , Gunawan Teddy Surya , Khalifa Othman O , Kartiwi Mira , Dao Hassan 
Published: October 2017

<table width="593" border="0" cellspacing="0" cellpadding="0"><tbody><tr><td valign="top" width="387"><p class="Text">The speech enhancement algorithms are utilized to overcome multiple limitation factors in recent applications such as mobile phone and communication channel. The challenges focus on corrupted speech solution between noise reduction and signal distortion. We used a modified Wiener filter and compressive sensing (CS) to investigate and evaluate the improvement of speech quality. This new method adapted noise estimation and Wiener filter gain function in which to increase weight amplitude spectrum and improve mitigation of interested signals. The CS is then applied using the gradient projection for sparse reconstruction (GPSR) technique as a study system to empirically investigate the interactive effects of the corrupted noise and obtain better perceptual improvement aspects to listener fatigue with noiseless reduction conditions. The proposed algorithm shows an enhancement in testing performance evaluation of objective assessment tests outperform compared to other conventional algorithms at various noise type conditions of 0, 5, 10, 15 dB SNRs. Therefore, the proposed algorithm significantly achieved the speech quality improvement and efficiently obtained higher performance resulting in better noise reduction compare to other conventional algorithms. </p></td></tr></tbody></table>