bluuebunny/crossref_metadata_2025_split huggingface dataset:
Why seeking feedback from diverse sources may not be sufficient for stimulating creativity: The role of performance dynamism and creative time pressure
Authors: Sijbom Roy B. L. , Anseel Frederik , Crommelinck Michiel , De Beuckelaer Alain , De Stobbeleir Katleen E. M. 
Published: September 2017

SummaryWe explore how the impact of seeking feedback from different sources (i.e., feedback source variety) on employee creativity is shaped by perceptions of the work environment. Specifically, we argue that two contextual factors, namely, performance dynamism (Study 1) and creative time pressure (Study 2), moderate the relationship between feedback source variety and creativity such that under conditions of high performance dynamism and low creative time pressure, individuals benefit from diverse feedback information. In Study 1 (N = 1,031), the results showed that under conditions of high performance dynamism, the relationship between feedback source variety and self‐reported creativity was nonlinear, with employee creativity exponentially increasing as a function of feedback source variety. Similarly, in Study 2 (N = 181), we found that under conditions of low creative time pressure, the relationship between feedback source variety and employee creativity was nonlinear, with supervisor‐rated creative performance exponentially increasing at higher levels of feedback source variety. Such results highlight that the relationship between feedback source variety and creative performance is affected by the perceptions of the work environment in which feedback is sought.
Development and initial validation of a novel smoothed‐particle hydrodynamics‐based simulation model of trabecular bone penetration by metallic implants
Authors: Kulper Sloan A. , Fang Christian X. , Ren Xiaodan , Guo Margaret , Sze Kam Y. , Leung Frankie K. L. , Lu William W. 
Published: September 2017

ABSTRACTA novel computational model of implant migration in trabecular bone was developed using smoothed‐particle hydrodynamics (SPH), and an initial validation was performed via correlation with experimental data. Six fresh‐frozen human cadaveric specimens measuring 10 × 10 × 20 mm were extracted from the proximal femurs of female donors (mean age of 82 years, range 75–90, BV/TV ratios between 17.88% and 30.49%). These specimens were then penetrated under axial loading to a depth of 10 mm with 5 mm diameter cylindrical indenters bearing either flat or sharp/conical tip designs similar to blunt and self‐tapping cancellous screws, assigned in a random manner. SPH models were constructed based on microCT scans (17.33 µm) of the cadaveric specimens. Two initial specimens were used for calibration of material model parameters. The remaining four specimens were then simulated in silico using identical material model parameters. Peak forces varied between 92.0 and 365.0 N in the experiments, and 115.5–352.2 N in the SPH simulations. The concordance correlation coefficient between experimental and simulated pairs was 0.888, with a 95%CI of 0.8832–0.8926, a Pearson ρ (precision) value of 0.9396, and a bias correction factor Cb (accuracy) value of 0.945. Patterns of bone compaction were qualitatively similar; both experimental and simulated flat‐tipped indenters produced dense regions of compacted material adjacent to the advancing face of the indenter, while sharp‐tipped indenters deposited compacted material along their peripheries. Simulations based on SPH can produce accurate predictions of trabecular bone penetration that are useful for characterizing implant performance under high‐strain loading conditions. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1114–1123, 2018.
Does Lesion Size Affect the Value of Shear Wave Elastography for Differentiating Between Benign and Malignant Thyroid Nodules?
Authors: Wang Fen , Chang Cai , Chen Min , Gao Yi , Chen Ya‐Ling , Zhou Shi‐Chong , Li Jia‐Wei , Zhi Wen‐Xiang 
Published: September 2017

ObjectivesWe aimed to investigate the diagnostic performance of shear wave elastography (SWE) combined with conventional ultrasonography (US) for differentiating between benign and malignant thyroid nodules of different sizes.MethodsA total of 445 thyroid nodules from 445 patients were divided into 3 groups based on diameter (group 1, ≤ 10 mm; group 2, 10–20 mm; and group 3, > 20 mm). The mean elasticity index of the whole lesion was automatically calculated, and the threshold for differentiation between benign and malignant nodules was constructed by a receiver operating characteristic curve analysis. Diagnostic performances of conventional US and SWE were compared by using pathologic results as reference standards.ResultsThe mean elasticity was significantly higher in malignant versus benign nodules for all size groups. The differences in mean elasticity in the size groups were not statistically significant for malignant or benign nodules. The specificity of US combined with SWE for group 1 was significantly higher than that for groups 2 and 3 (77.8% versus 62.9% and 53.3%; P < .05), and compared with group 1, the sensitivity was significantly higher for groups 2 and 3 (92.4% and 94.3% versus 80.7%; P < .05). When SWE was added, the specificity increased and the sensitivity and diagnostic accuracy decreased for group 1, and the sensitivity increased and the specificity decreased for groups 2 and 3; however, the differences were not significant.ConclusionsCombined with SWE, US yielded higher specificity for nodules of 10 mm and smaller and higher sensitivity for nodules larger than 10 mm.
Microdosimetric measurements of a clinical proton beam with micrometer‐sized solid‐state detector
Authors: Anderson Sarah E. , Furutani Keith M. , Tran Linh T. , Chartier Lachlan , Petasecca Marco , Lerch Michael , Prokopovich Dale A. , Reinhard Mark , Perevertaylo Vladimir L. , Rosenfeld Anatoly B. , Herman Michael G. , Beltran Chris 
Published: September 2017

PurposeMicrodosimetry is a vital tool for assessing the microscopic patterns of energy deposition by radiation, which ultimately govern biological effect. Solid‐state, silicon‐on‐insulator microdosimeters offer an approach for making microdosimetric measurements with high spatial resolution (on the order of tens of micrometers). These high‐resolution, solid‐state microdosimeters may therefore play a useful role in characterizing proton radiotherapy fields, particularly for making highly resolved measurements within the Bragg peak region. In this work, we obtain microdosimetric measurements with a solid‐state microdosimeter (MicroPlus probe) in a clinical, spot‐scanning proton beam of small spot size.MethodsThe MicroPlus probe had a 3D single sensitive volume on top of silicon oxide. The sensitive volume had an active cross‐sectional area of 250 μm × 10 μm and thickness of 10 μm. The proton facility was a synchrotron‐based, spot‐scanning system with small spot size (σ ≈ 2 mm). We performed measurements with the clinical beam current (≈1 nA) and had no detected pulse pile‐up. Measurements were made in a water‐equivalent phantom in water‐equivalent depth (WED) increments of 0.25 mm or 1.0 mm along pristine Bragg peaks of energies 71.3 MeV and 159.9 MeV, respectively. For each depth, we measured lineal energy distributions and then calculated the dose‐weighted mean lineal energy, . The measurements were repeated for two field sizes: 4 × 4 cm2 and 20 × 20 cm2.ResultsFor both 71.3 MeV and 159.9 MeV and for both field sizes, increased with depth toward the distal edge of the Bragg peak, a result consistent with Monte Carlo calculations and measurements performed elsewhere. For the 71.3 MeV, 4 × 4 cm2 beam (range at 80% distal falloff, R80 = 3.99 cm), we measured keV/μm at WED = 2 cm, and keV/μm at WED = 3.95 cm. For the 71.3 MeV, 20 × 20 cm2 beam, we measured keV/μm at WED = 2.6 cm, and keV/μm at WED = 3 cm. For the 159.9 MeV, 4 × 4 cm2 beam (R80 = 17.7 cm), keV/μm at WED = 5 cm, and keV/μm at WED = 17.6 cm. For the 159.9 MeV, 20 × 20 cm2 beam, keV/μm at WED = 5 cm, and keV/μm at WED = 17.6 cm.ConclusionsWe performed microdosimetric measurements with a novel solid‐state, silicon‐on‐insulator microdosimeter in a clinical spot‐scanning proton beam of small spot size and unmodified beam current. For all of the proton field sizes and energies considered, the measurements of were in agreement with expected trends. Furthermore, we obtained measurements with a spatial resolution of 10 μm in the beam direction. This spatial resolution greatly exceeded that possible with a conventional gaseous tissue‐equivalent proportional counter and allowed us to perform a high‐resolution investigation within the Bragg peak region. The MicroPlus probe is therefore suitable for applications in proton radiotherapy.
Steer‐PROP: a GRASE‐PROPELLER sequence with interecho steering gradient pulses
Authors: Srinivasan Girish , Rangwala Novena , Zhou Xiaohong Joe 
Published: September 2017

PurposeThis study demonstrates a novel PROPELLER (periodically rotated overlapping parallel lines with enhanced reconstruction) pulse sequence, termed Steer‐PROP, based on gradient and spin echo (GRASE), to reduce the imaging times and address phase errors inherent to GRASE. The study also illustrates the feasibility of using Steer‐PROP as an alternative to single‐shot echo planar imaging (SS‐EPI) to produce distortion‐free diffusion images in all imaging planes.MethodsSteer‐PROP uses a series of blip gradient pulses to produce N (N = 3‐5) adjacent k‐space blades in each repetition time, where N is the number of gradient echoes in a GRASE sequence. This sampling strategy enables a phase correction algorithm to systematically address the GRASE phase errors as well as the motion‐induced phase inconsistency. Steer‐PROP was evaluated on phantoms and healthy human subjects at both 1.5T and 3.0T for T2‐ and diffusion‐weighted imaging.ResultsSteer‐PROP produced similar image quality as conventional PROPELLER based on fast spin echo (FSE), while taking only a fraction (e.g., 1/3) of the scan time. The robustness against motion in Steer‐PROP was comparable to that of FSE‐based PROPELLER. Using Steer‐PROP, high quality and distortion‐free diffusion images were obtained from human subjects in all imaging planes, demonstrating a considerable advantage over SS‐EPI.ConclusionThe proposed Steer‐PROP sequence can substantially reduce the scan times compared with FSE‐based PROPELLER while achieving adequate image quality. The novel k‐space sampling strategy in Steer‐PROP not only enables an integrated phase correction method that addresses various sources of phase errors, but also minimizes the echo spacing compared with alternative sampling strategies. Steer‐PROP can also be a viable alternative to SS‐EPI to decrease image distortion in all imaging planes. Magn Reson Med 79:2533–2541, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Simple method for RF pulse measurement using gradient reversal
Authors: Landes Vanessa L. , Nayak Krishna S. 
Published: September 2017

PurposeTo develop and evaluate a simple method for measuring the envelope of small‐tip radiofrequency (RF) excitation waveforms in MRI, without extra hardware or synchronization.Theory and MethodsGradient reversal approach to evaluate RF (GRATER) involves RF excitation with a constant gradient and reversal of that gradient during signal reception to acquire the time‐reversed version of an RF envelope. An outer‐volume suppression prepulse is used optionally to preselect a uniform volume. GRATER was evaluated in phantom and in vivo experiments. It was compared with the programmed waveform and the traditional pick‐up coil method.ResultsIn uniform phantom experiments, pick‐up coil, GRATER, and outer‐volume suppression + GRATER matched the programmed waveforms to less than 2.1%, less than 6.1%, and less than 2.4% normalized root mean square error, respectively, for real RF pulses with flip angle less than or equal to 30°, time‐bandwidth product 2 to 8, and two to five excitation bands. For flip angles greater than 30°, GRATER measurement error increased as predicted by Bloch simulation. Fat‐water phantom and in vivo experiments with outer‐volume suppression + GRATER demonstrated less than 6.4% normalized root mean square error.ConclusionsThe GRATER sequence measures small‐tip RF envelopes without extra hardware or synchronization in just over two times the RF duration. The sequence may be useful in prescan calibration and for measurement and precompensation of RF amplifier nonlinearity. Magn Reson Med 79:2642–2651, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Preemptive parallel‐machine scheduling with a common server to minimize makespan
Authors: Cheng T.C.E. , Kravchenko Svetlana A. , Lin Bertrand M.T. 
Published: September 2017

AbstractWe consider parallel‐machine scheduling with a common server and job preemption to minimize the makespan. While the non‐preemptive version of the problem is strongly NP‐hard, the complexity status of the preemptive version has remained open. We show that the preemptive version is NP‐hard even if there is a fixed number of machines. We give a pseudo‐polynomial time algorithm to solve the case with two machines. We show that the case with an arbitrary number of machines is unary NP‐hard, analyze the performance ratios of some natural heuristic algorithms, and present several solvable special cases. © 2017 Wiley Periodicals, Inc. Naval Research Logistics 64: 388–398, 2017
Research to support optimization of prescription drug monitoring programs
Authors: Doyle Sheri , Leichtling Gillian , Hildebran Christi , Reilly Cynthia 
Published: September 2017

AbstractPurposeResearch is needed to evaluate the impact of prescription drug monitoring programs (PDMPs). This paper describes research priorities for PDMPs that were initially discussed at a 2015 meeting of PDMP administrators, researchers, public health officials, and other stakeholders.MethodsMeeting participants defined the current landscape of PDMP research and identified research gaps. Research priorities were grouped by theme.ResultsPrescription drug monitoring program research priorities were identified for 3 key areas: individual patient health outcomes, prescriber use and decision making, and population‐level outcomes. Research areas for individual patient outcomes include examining drug‐use thresholds that best predict risk for overdose or substance use disorder and unintended consequences of PDMP use. Proposed research on prescriber PDMP use include evaluating how enhancements to the content and format of PDMP reports informs clinical decision making and optimal clinician actions in response to a concerning PDMP report. Finally, research topics related to population‐level outcomes include measuring the impact of PDMP policies on the incidence of substance misuse and harms and assessing the return on investment for these databases.ConclusionsThe clinical, public health, and economic impacts of PDMPs must be evaluated, using both quantitative and qualitative methods. In addition to assessing patient outcomes, qualitative research should examine how clinicians use and interpret PDMP information. Research should also examine the impact of PDMP features and policies on prescriber utilization. Comparative analyses across states with differing PDMP policies should be conducted to inform best practices.
Isatin‐induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction
Authors: Ershov Pavel , Mezentsev Yuri , Gilep Andrey , Usanov Sergey , Buneeva Olga , Medvedev Alexei , Ivanov Alexis 
Published: September 2017

AbstractIsatin (indol‐2,3‐dione) is an endogenous non‐peptide regulator exhibiting a wide range of biological and pharmacological activities, which are poorly characterized in terms of their molecular mechanisms. Identification of many isatin‐binding proteins in the mammalian brain and liver suggests that isatin may influence their functions. We have hypothesized that besides direct action on particular protein targets, isatin can act as a regulator of protein–protein interactions (PPIs). In this surface plasmon resonance‐based biosensor study we have found that physiologically relevant concentrations of isatin (25‐100 μM) increase affinity of interactions between human recombinant ferrochelatase (FECH) and NADPH‐dependent adrenodoxin reductase (ADR). In the presence of increasing concentrations of isatin the Kd values demonstrated a significant (up to 6‐fold) decrease. It is especially important that the interaction of isatin with each individual protein (FECH, ADR) was basically negligible and therefore could not contribute to the observed effect. This effect was specific only for the FECH/ADR complex formation and was not observed for other protein complexes studied: FECH/cytochrome b5(CYB5A) and FECH/SMAD4.
Somatostatin receptor subtype 1 as a potential diagnostic marker and therapeutic target in prostate cancer
Authors: Pedraza‐Arévalo Sergio , Hormaechea‐Agulla Daniel , Gómez‐Gómez Enrique , Requena María J. , Selth Luke A. , Gahete Manuel D. , Castaño Justo P. , Luque Raul M. 
Published: September 2017

BackgroundProstate cancer (PCa) is a highly prevalent neoplasia that is strongly influenced by the endocrine system. Somatostatin (SST) and its five receptors (sst1‐5 encoded by SSTR1‐5 genes) comprise a pleiotropic system present in most endocrine‐related cancers, some of which are successfully treated with SST analogs. Interestingly, it has been reported that SSTR1 is overexpressed in PCa, but its regulation, functional role, and clinical implications are still poorly known.MethodsPCa specimens (n = 52) from biopsies and control prostates from cystoprostatectomies (n = 12), as well as in silico databases were used to evaluate SSTR1 and miRNAs expression. In vitro studies in 22Rv1 PCa cells were implemented to explore the regulation of SSTR1/sst1 by different miRNAs, and to evaluate the consequences of SSTR1/sst1 overexpression, silencing and/or activation [with the specific BIM‐23926 sst1 agonist (IPSEN)] on cell‐proliferation, migration, signaling‐pathways, and androgen‐signaling.ResultsWe found that SSTR1 is overexpressed in multiple cohorts of PCa samples, as compared with normal prostate tissues, wherein it correlates with androgen receptor (AR) expression, and appears to be associated with aggressiveness (metastasis). Furthermore, our data revealed that SSTR1/sst1 expression might be regulated by specific miRNAs in PCa, including miR‐24, which is downregulated in PCa samples and correlates inversely with SSTR1 expression. In vitro studies indicated that treatment with the BIM‐23926 sst1 agonist, as well as SSTR1 overexpression, decreased, whereas SSTR1 silencing increased, cell‐proliferation in 22Rv1 cells, likely through the regulation of PI3K/AKT‐CCND3 signaling‐pathway. Importantly, sst1 action was also able to modulate androgen/AR activity, and reduced PSA secretion from PCa cell lines.ConclusionsAltogether, our results indicate that SSTR1 is overexpressed in PCa, where it can exert a relevant pathophysiological role by decreasing cell‐proliferation and PSA secretion. Therefore, sst1, possibly in combination with miR‐24, could be used as a novel tool to explore therapeutic targets in PCa.
Modeling of protein complexes in CAPRI Round 37 using template‐based approach combined with model selection
Authors: Dapkūnas Justas , Olechnovič Kliment , Venclovas Česlovas 
Published: September 2017

AbstractWe participated in Round 37 of the Critical Assessment of PRediction of Interactions (CAPRI), held jointly with the 12th edition of the Critical Assessment of protein Structure Prediction (CASP12), having two major objectives. First, we intended to test the utility of our PPI3D web server in finding and selecting templates for comparative modeling of structures of protein complexes. Our second aim was to evaluate the ability of our model accuracy estimation method VoroMQA to score and rank structural models for protein‐protein interactions. Using sequence search in PPI3D and HHpred servers we identified multimeric templates for 7 of 11 CAPRI targets, and models of at least acceptable quality were constructed for 6 of them. The clustering and visual analysis features implemented in the PPI3D software were instrumental in detecting alternative protein‐protein interaction interfaces among the identified templates. When a single binding mode was observed for homologous proteins, the structural modeling of the protein complex was fairly straightforward, whereas choosing the correct interaction template from several alternatives turned out to be a difficult task requiring manual intervention. The combination of full structure and interaction interface VoroMQA scores effectively ranked structural models of protein complexes and selected models of better quality from the CAPRI Scoring sets. The overall results show possible uses of PPI3D and VoroMQA in structural modeling of protein‐protein interactions and suggest ways for further improvements of both methods.
Anion induced conformational preference of CαNN motif residues in functional proteins
Authors: Patra Piya , Ghosh Mahua , Banerjee Raja , Chakrabarti Jaydeb 
Published: September 2017

AbstractAmong different ligand binding motifs, anion binding CαNN motif consisting of peptide backbone atoms of three consecutive residues are observed to be important for recognition of free anions, like sulphate or biphosphate and participate in different key functions. Here we study the interaction of sulphate and biphosphate with CαNN motif present in different proteins. Instead of total protein, a peptide fragment has been studied keeping CαNN motif flanked in between other residues. We use classical force field based molecular dynamics simulations to understand the stability of this motif. Our data indicate fluctuations in conformational preferences of the motif residues in absence of the anion. The anion gives stability to one of these conformations. However, the anion induced conformational preferences are highly sequence dependent and specific to the type of anion. In particular, the polar residues are more favourable compared to the other residues for recognising the anion.
Investigating the structural dynamics of the PIEZO1 channel activation and inactivation by coarse‐grained modeling
Authors: Zheng Wenjun , Sachs Frederick 
Published: September 2017

AbstractThe PIEZO channels, a family of mechanosensitive channels in vertebrates, feature a fast activation by mechanical stimuli (eg, membrane tension) followed by a slower inactivation. Although a medium‐resolution structure of the trimeric form of PIEZO1 was solved by cryo‐electron microscopy (cryo‐EM), key structural changes responsible for the channel activation and inactivation are still unknown. Toward decrypting the structural mechanism of the PIEZO1 activation and inactivation, we performed systematic coarse‐grained modeling using an elastic network model and related modeling/analysis tools (ie, normal mode analysis, flexibility and hotspot analysis, correlation analysis, and cryo‐EM‐based hybrid modeling and flexible fitting). We identified four key motional modes that may drive the tension‐induced activation and inactivation, with fast and slow relaxation time, respectively. These modes allosterically couple the lateral and vertical motions of the peripheral domains to the opening and closing of the intra‐cellular vestibule, enabling external mechanical forces to trigger, and regulate the activation/inactivation transitions. We also calculated domain‐specific flexibility profiles, and predicted hotspot residues at key domain‐domain interfaces and hinges. Our results offer unprecedented structural and dynamic information, which is consistent with the literature on mutational and functional studies of the PIEZO channels, and will guide future studies of this important family of mechanosensitive channels.