bluuebunny/crossref_metadata_2025_split huggingface dataset:
User experience of creative class district: Punavuori neighborhood
Authors: Tähtinen Sari , Kojo Inka , Nenonen Suvi 
Published: June 2016

Purpose
This paper aims to present empirical testing of an experience-based usability framework to study an urban area. The framework is applied to the Punavuori neighbourhood in Helsinki, Finland, to understand the issues that make this neighbourhood attractive to its users.

Design/methodology/approach
The experience-based usability framework for an urban area study is the 6T-model of experience of place, which was developed by combining service and experience design tools and methods as well as former research to assess the user’s experience. The framework is tested by analysing data gathered from documents, a walkthrough of the neighbourhood and interviews.

Findings
This paper interprets users’ experiences of the Punavuori area using the 6T-model to capture new perspectives on user-centric urban design and the management of places. The identified connections can be a starting point for investigations into users’ experiences as a part of the usability of an urban area.

Research limitations/implications
The results represent a beginning study into the usability and the usability experience of individuals in the built environment. The preliminary testing of the experience framework is used as a framework for the analysis of the secondary data. The user data have not been gathered in the broadest sense.

Practical implications
The results can be used in other experience-based research for (re-)design an existing or new area that attracts new inhabitants and business. The results can be applied by urban planners as well as place managers.

Originality/value
The identified points of connection provide a valuable approach to capture and discuss about user experiences in complex urban context.
A meta-synthesis of academic and social characteristic studies
Authors: Hicks Terence , Wood J. Luke 
Published: June 2016

PurposeGiven that a relatively large percentage of college students entering historically black colleges and universities (HBCUs) are first-generation students and considering the low completion rate among this group in the science, technology, engineering and mathematics (STEM) discipline, the purpose of this preliminary meta-synthesis study is intended to facilitate a greater understanding of the academic and social adjustment among college students, particularly first-generation college students enrolled in STEM disciplines at HBCUs. Therefore, this meta-synthesis will shed light and offer important recommendations for university administrators and faculty members in supporting the academic and social adjustment of these students in STEM fields at HBCUs.Design/methodology/approachThis review of literature was conducted using a meta-synthesis approach (also referred to as integrative review). A meta-synthesis is based on a process by which findings across multiple studies are organized and presented (Turner, Gonzalez and Wood, 2008; Wood, 2010). This approach is used to provide insight to academicians and practitioners alike on the status of research on a given phenomenon (Bland, Meurer and Maldonado, 1995; Patterson, Thorne, Canam and Jillings, 2001; Wood, 2010). We engaged in a cyclical process of collecting, annotating, and synthesizing research over a 45-year time-frame (1970 to 2015). This produced over 50 cited resources with more than 100 scholars including peer-reviewed articles, reports, books, book chapters, and conference papers.FindingsFactors present in the literature that affected students enrolled in a STEM program at a HBCU are grouped into three contexts: (a) first-generation academic and social characteristics, (b) first-generation college dropout and transition, and (c) first-generation STEM retention. Tables 2 to 4 provide these contexts by author and year of publication. Within these general groupings, four interrelated themes emerged from the literature: (a) prior academic performance and STEM discipline, (b) college adjustment and STEM discipline, (c) social integration and STEM discipline, and (d) academic integration and STEM discipline.Originality/valueThis information may help professors and university professionals in the STEM fields to be more aware of the challenges faced by incoming college students. More empirical work is needed in this area in a way that is useful for understanding and enhancing professors’ and university professionals’ knowledge. To this end, research that carefully describes what HBCU professors and university professionals know or their ideas about teaching college students, especially first-generation students enrolled in the STEM discipline, is needed.
More than an intervention: strategies for increasing diversity and inclusion in STEM
Authors: Jones Sosanya 
Published: June 2016

Purpose
This paper aims to provide insight into the strategies used by leaders of graduate school preparation programs for science, technology, engineering and mathematics (STEM) to recruit and retain graduate students of color within STEM fields.

Design/methodology/approach
This paper is a qualitative multiple-case study using a snowball sample and semi-structured interview protocol. Twenty interviews were conducted.

Findings
Graduate program leaders use particular strategies to increase diversity and inclusion within graduate STEM education, and these strategies are strongly influenced by their institutional context. The most common strategies include collaboration, mapping the political terrain, evaluation, mediation, persistence, persuasion, networking in and outside of the institution, strategic planning, bargaining and negotiation, reaching out to the greater campus, and coalition building and developing allies.

Research limitations/implications
All of the institutions in this study were public research institutions. Further inquiry is needed on more diverse types of institutions.

Practical implications
The results of this study can be used by institutional and STEM program leaders who wish to increase diversity and inclusion.

Social implications
This research study raises awareness about an under-studied group of leaders, as well as the importance of considering context when developing strategic plans for increasing diversity and inclusion for STEM.

Originality/value
This study is unique because while graduate school preparation programs have become an important strategy for addressing diversity in STEM fields, research on these programs usually focuses only on student outcomes. This study provides rare insight into what is required to implement, sustain and expand these kind of diversity programs.
Mutation of the toxR or mshA genes from Vibrio coralliilyticus strain OCN014 reduces infection of the coral Acropora cytherea
Authors: Ushijima Blake , Videau Patrick , Poscablo Donna , Stengel John W. , Beurmann Silvia , Burger Andrew H. , Aeby Greta S. , Callahan Sean M. 
Published: June 2016

SummaryThermal stress increases the incidence of coral disease, which is predicted to become more common with climate change, even on pristine reefs such as those surrounding Palmyra Atoll in the Northern Line Islands that experience minimal anthropogenic stress. Here we describe a strain of Vibrio coralliilyticus, OCN014, which was isolated from Acropora cytherea during an outbreak of Acropora white syndrome (AWS), a tissue loss disease that infected 25% of the A. cytherea population at Palmyra Atoll in 2009. OCN014 recreated signs of disease in experimentally infected corals in a temperature‐dependent manner. Genes in OCN014 with expression levels positively correlated with temperature were identified using a transposon‐mediated genetic screen. Mutant strains harbouring transposon insertions in two such genes, toxR (a toxin regulator) and mshA (the 11th gene of the 16‐gene mannose‐sensitive hemagglutinin (MSHA) type IV pilus operon), had reduced infectivity of A. cytherea. Deletion of toxR and the MSHA operon in a second strain of V. coralliilyticus, OCN008, that induces acute Montipora white syndrome in a temperature‐independent manner had similarly reduced virulence. This work provides a link between temperature‐dependent expression of virulence factors in a pathogen and infection of its coral host.
Light governs asexual differentiation in the grey mould fungus Botrytis cinerea via the putative transcription factor BcLTF2
Authors: Cohrs Kim C. , Simon Adeline , Viaud Muriel , Schumacher Julia 
Published: June 2016

SummaryBotrytis cinerea is a plant pathogenic fungus known for its utilization of light as environmental cue to regulate asexual differentiation: conidia are formed in the light, while sclerotia are formed in the dark. As no orthologues of known regulators of conidiation (e.g., Aspergillus nidulans BrlA, Neurospora crassa FL) exist in the Leotiomycetes, we initiated a de novo approach to identify the functional counterpart in B. cinerea. The search revealed the light‐responsive C2H2 transcription factor BcLTF2 whose expression – usually restricted to light conditions – is necessary and sufficient to induce conidiation and simultaneously to suppress sclerotial development. Light‐induced expression of bcltf2 is mediated via a so far unknown pathway, and is attenuated in a (blue) light‐dependent fashion by the White Collar complex, BcLTF1 and the VELVET complex. Mutation of either component leads to increased bcltf2 expression and causes light‐independent conidiation (always conidia phenotype). Hence, the tight regulation of bcltf2 governs the balance between vegetative growth that allows for the colonization of the substrate and subsequent reproduction via conidia in the light. The orthologue ssltf2 in the closely related species Sclerotinia sclerotiorum is not significantly expressed suggesting that its deregulation may cause the lack of the conidiation program in this fungus.
Metagenomics unveils the attributes of the alginolytic guilds of sediments from four distant cold coastal environments
Authors: Matos Marina N. , Lozada Mariana , Anselmino Luciano E. , Musumeci Matías A. , Henrissat Bernard , Jansson Janet K. , Mac Cormack Walter P. , Carroll JoLynn , Sjöling Sara , Lundgren Leif , Dionisi Hebe M. 
Published: June 2016

SummaryAlginates are abundant polysaccharides in brown algae that constitute an important energy source for marine heterotrophic bacteria. Despite the key role of alginate degradation processes in the marine carbon cycle, little information is available on the bacterial populations involved in these processes. The aim of this work was to gain a better understanding of alginate utilization capabilities in cold coastal environments. Sediment metagenomes from four high‐latitude regions of both Hemispheres were interrogated for alginate lyase gene homologue sequences and their genomic context. Sediments contained highly abundant and diverse bacterial assemblages with alginolytic potential, including members of Bacteroidetes and Proteobacteria, as well as several poorly characterized taxa. The microbial communities in Arctic and Antarctic sediments exhibited the most similar alginolytic profiles, whereas brackish sediments showed distinct structures with a higher proportion of novel genes. Examination of the gene neighbourhood of the alginate lyase homologues revealed distinct patterns depending on the potential lineage of the scaffolds, with evidence of evolutionary relationships among alginolytic gene clusters from Bacteroidetes and Proteobacteria. This information is relevant for understanding carbon fluxes in cold coastal environments and provides valuable information for the development of biotechnological applications from brown algae biomass.
Insulin‐like growth factor binding protein 1, Bishop score, and sonographic cervical length: tolerability and prediction of vaginal birth and vaginal birth within 24 hours following labour induction in nulliparous women
Authors: Vallikkannu N , Lam WK , Omar SZ , Tan PC 
Published: June 2016

ObjectiveTo evaluate the tolerability of cervical insulin‐like growth factor binding protein 1 (IGFBP‐1) and its value as a predictor of successful labour induction, compared with Bishop score and transvaginal ultrasound (TVUS) cervical length.DesignA prospective study.SettingA tertiary hospital in Malaysia.PopulationA cohort of 193 term nulliparous women with intact membranes.MethodsPrior to labour induction, cervical fluid was obtained via a vaginal speculum and tested for IGFBP‐1, followed by TVUS and finally Bishop score. After each assessment the procedure‐related pain was scored from 0 to 10. Cut‐off values for Bishop score and cervical length were obtained from the receiver operating characteristic (ROC) curve. Multivariable logistic regression analysis was performed.Main outcomes measuresVaginal delivery and vaginal delivery within 24 hours of starting induction.ResultsBedside IGFBP‐1 testing is better tolerated than Bishop score, but is less well tolerated than TVUS [median (interquartile range) of pain scores: 5 (4–5) versus 6 (5–7) versus 3 (2–3), respectively; P < 0.001]. IGFBP‐1 independently predicted vaginal delivery (adjusted odds ratio, AOR 5.5; 95% confidence interval, 95% CI 2.3–12.9) and vaginal delivery within 24 hours of induction (AOR 4.9; 95% CI 2.1–11.6) after controlling for Bishop score (≥4 or ≥5), cervical length (≤29 or ≤27 mm), and other significant characteristics for which the Bishop score and TVUS were not predictive of vaginal delivery after adjustment. IGFBP‐1 has 81% sensitivity, 59% specificity, positive and negative predictive values of 82 and 58%, respectively, and positive and negative likelihood ratios of 2.0 and 0.3 for vaginal delivery, respectively.ConclusionIGFBP‐1 better predicted vaginal delivery than BS or TVUS, and may help guide decision making regarding labour induction in nulliparous women.Tweetable abstractIGFBP‐1: a stronger independent predictor of labour induction success than Bishop score or cervical sonography.
Labour pain with remifentanil patient‐controlled analgesia versus epidural analgesia: a randomised equivalence trial
Authors: Logtenberg SLM , Oude Rengerink K , Verhoeven CJ , Freeman LM , van den Akker ESA , Godfried MB , van Beek E , Borchert OWHM , Schuitemaker N , van Woerkens ECSM , Hostijn I , Middeldorp JM , van der Post JA , Mol BW 
Published: June 2016

ObjectiveTo distinguish satisfaction with pain relief using remifentanil patient‐controlled analgesia (RPCA) compared with epidural analgesia (EA) in low‐risk labouring women.DesignRandomised controlled equivalence trial.SettingEighteen midwifery practices and six hospitals in the Netherlands.PopulationA total of 408 pregnant women at low risk for obstetric complications initially under the care of primary‐care midwives.MethodsWomen randomised before active labour to receive analgesia with RPCA or EA, if requested.Main outcome measuresPrimary outcome was satisfaction with pain relief measured hourly using a visual analogue scale and summed as area under the curve (AUC). Secondary outcomes were overall satisfaction with pain relief, pain intensity scores during labour, mode of delivery, and maternal and neonatal outcomes.ResultsWe randomised 418 women, of whom 409 could be followed for the primary endpoint. Analgesia was received by 46% (94/203) in the remifentanil group and 37% (76/206) in the epidural group. The AUC for satisfaction with pain relief was 32 in the remifentanil group and 31 in the epidural group (mean difference −0.50; 95% CI −6.8 to 5.9). Among women who actually received analgesia, these values were 23 and 35, respectively (mean difference −12; 95% CI −22 to −1.5). Secondary outcomes were comparable.ConclusionsIn low‐risk labouring women, we could not demonstrate equivalence between a strategy with RPCA to EA with respect to satisfaction with pain relief assessed during the total duration of labour. However, once applied satisfaction was higher in women who received epidural analgesia.Tweetable abstractSatisfaction with pain relief is higher in women receiving epidural analgesia compared with Remifentanil PCA.
Rural Development Programmes and Transaction Effects: Reflections on Maltese and English Experience
Authors: Dwyer Janet , Powell John 
Published: June 2016

AbstractNew institutional economics, and transaction effects in particular, are highly relevant to public policy performance. The evolution ofEUrural development policy has generated both increasing complexity and increased transaction costs. However, this policy evolution also creates opportunities for improvement of policy process management. The paper considers these opportunities in the case of Rural Development Programmes (RDPs) under Pillar 2 of theCAP. We examine the influence of transaction effects onRDPperformance, based on direct experience ofRDPreview and planning in England and Malta, where qualitative evidence of ‘transaction benefits’ is identified. Benefits occur when exchange processes are designed in ways that generate positive returns beyond the immediate transaction, which can outweigh short‐term costs. We conclude that more attention to these aspects of policy design is warranted in future rural development programming and evaluation.
Price Endogeneity and Food Demand in Urban China
Authors: Hovhannisyan Vardges , Bozic Marin 
Published: June 2016

AbstractPrice endogeneity has been ignored in previous analyses of food demand in urban China. We exploit data provided by the China National Bureau of Statistics on agricultural commodity supply shifters and use reduced‐form price equations to account for price endogeneity. Applying our unique econometric approach to the analysis of provincial‐level food demand in China, we find strong statistical evidence of price endogeneity. Models that ignore price endogeneity result in substantially biased elasticities and misleading estimates of future food demand in China.
The TARGET pain study: Lessons from a painful marathon
Authors: Thom Ogilvie N , Keijzers Gerben , Taylor David McD , Fatovich Daniel M , Finucci Daniel P , Furyk Jeremy , Jin Sang‐won , Macdonald Stephen PJ , Mitenko Hugh MA , Richardson Joanna R , Ting Joseph YS , Gibbs Clinton R , Chalkley Dane R 
Published: June 2016

AbstractThis perspective article summarises the experience of conducting a multicentre research project. We describe expected and unexpected hurdles we experienced as well as suggesting possible solutions for researchers embarking on multicentre studies.
Changing attitudes towards management of men with locally advanced prostate cancer following radical prostatectomy: A follow‐up survey of Australia‐based urologists
Authors: Brown Bernadette , Egger Sam , Young Jane , Kneebone Andrew B , Brooks Andrew J , Dominello Amanda , Haines Mary 
Published: June 2016

AbstractIntroductionThis study examined whether there has been change among Australia‐based urologists' knowledge, attitudes and beliefs relating to guideline‐recommended adjuvant radiotherapy for men with adverse pathologic features following radical prostatectomy since a prior survey in 2012 and investigated associations between attitudes and treatment preferences.MethodsA nationwide survey of Australia‐based urologist members of the Urological Society of Australia and New Zealand.ResultsNinety‐six respondents completed the 2015 survey (30% response rate) compared with 157 (45% response rate) in 2012. There was no significant change in awareness of national clinical practice guidelines for the management of prostate cancer. When considering adjuvant against salvage radiotherapy, urologists were significantly less favourable towards adjuvant radiotherapy in 2015 than in 2012 for two of three hypothetical clinical case scenarios with a high 10‐year risk of biochemical relapse according to Memorial Sloan Kettering Cancer Center nomograms (P < 0.001 for both cases). In 2015, urologists were less positive overall towards the recommendation for post‐operative adjuvant radiotherapy for men with locally advanced prostate cancer than in 2012 (P < 0.001), reflecting a significant change across a number of attitudes and beliefs. Of note, urologists felt other urologists would more likely be critical if they routinely referred the target patient group for radiotherapy in 2015 compared with 2012 (P = 0.007).ConclusionIn 2015 Australia‐based urologists were less favourable towards adjuvant radiotherapy over watchful waiting for men with high‐risk pathologic features post‐prostatectomy than in 2012. We could find no new published research that precipitated this change in attitude.
Impact of antioxidant supplementations on cardio‐renal protection in cardiac surgery: an updated and comprehensive meta‐analysis and systematic review
Authors: Ali‐Hassan‐Sayegh Sadegh , Mirhosseini Seyed Jalil , Tahernejad Mahbube , Mahdavi Parisa , Shahidzadeh Azadeh , Karimi‐Bondarabadi Ali Akbar , Dehghan Ali‐Mohammad , Rahimizadeh Elham , Haddad Fatemeh , Ghodratipour Zahra , Sarrafan‐Chaharsoughi Zahra , Shahidzadeh Arezoo , Ghanei Azam , Lotfaliani Mohammadreza , Zeriouh Mohamed , Weymann Alexander , Popov Aron‐Frederik , Sabashnikov Anton 
Published: June 2016

SummaryThis systematic review with meta‐analysis sought to determine the strength of evidence in terms of the impact of common antioxidant supplementations, such as N‐acetylcysteine (NAC), vitamin C, and polyunsaturated fatty acids (PUFA) on perioperative outcomes after cardiac surgery with particular focus on the incidence of atrial fibrillation (AF) and acute kidney injury (AKI) with associated mortality. A total of 29 trials were identified that reported incidence of AF and 17 trials that reported incidence of AKI. Pooled analysis reported that NAC (OR=0.5; P=.001), vitamin C (OR=0.4; P=.001), and PUFA (OR=0.8; P=.01) administration were associated with significantly reduced incidence of AF. In terms of postoperative AKI, only NAC was shown to be a beneficial supplement that was able to significantly reduce the incidence of AKI (OR=0.7; P=.01), and NAC could also significantly decrease overall mortality (OR=0.3; P=.03) following cardiac surgery. The use of NAC in patients undergoing cardiac surgery should be strongly recommended due to its combined cardio‐renal protective effects and reduced mortality. Also, PUFA and vitamin C might be able to significantly decrease the incidence of arrhythmia; however, reno‐protective effects and impact on overall mortality of these supplements seem to be less impressive.
A New Pterodactyloid Pterosaur from the Early Cretaceous of the Western Part of Liaoning Province, Northeastern China
Authors: Junchang LÜ , Cunyu LIU , Lijun PAN , Caizhi SHEN 
Published: June 2016

AbstractPangupterus liui gen. et sp. nov. from the Jiufotang Formation of Sihedang, Lingyuan City, Liaoning Province is erected based on a nearly complete lower jaw. It is characterized by having a total of 36 slender curved teeth with sharp tips, forming a distinct fish‐grabbing mechanism; the teeth are well‐spaced and are circular in section; the length ratio of the mandibular symphysis to the whole jaw is 20%; and the ratio of the tooth root width to tooth length is 12%. Toothed pterosaurs make up about 56.3% of the pterosaur assemblage from the Jiufotang Formation, which indicates that toothed forms played a key role in the ecosystem.