bluuebunny/crossref_metadata_2025_split huggingface dataset:
Critical Networks
Authors: Watt Paul , Collins Sarah 
Published: April 2017

This article examines the idea of ‘Critical Networks’ as a way of studying the relational structures that shaped music criticism in the long nineteenth century. We argue that the personal, institutional and international networks that supported the dissemination of critical ideas about music are worthy of study in themselves, as they can yield insights beyond prevailing methodologies that centre on individual cases.Focusing on the institutional culture of music criticism means looking beyond the work of individual critics and the content or influence of their views, towards the structures that determined the authoritativeness of those views and the impact of these structures in shaping the operation of critical discourse on music at the time. Examining these networks and how they operated around particular periodicals, tracing transnational exchanges of both ideas and critics, and uncovering the various ideological alliances that were forged or contested within critical networks, can not only provide a thicker context for our understanding of historical ideas about music, but it can also challenge current views about the history of our discipline and the kinds of structures that condition our own ideas about music and music history.
Repoliticizing the Ancient Greek City, Thirty Years Later
Authors: Azoulay Vincent 
Published: April 2017

AbstractsThirty years after Nicole Loraux published her 1986 article inL’Homme, this study revisits the question of political experience in the ancient Greek world. Its aim is to demonstrate the importance of the two definitions of the term “politics” as conceived by the Ancient Greeks. On the one hand,the politicalwas conceived as an ensemble of activities with no specific institutional substance or form, a sphere of action that has no direct equivalent in the modern state, but rather relates to very varied experiences and practices undertaken in the context of conflict. On the other hand,politicswas understood not only as organized access to different institutions, but also as the way in which a community structured and defined itself. Taking the Athenian crisis of 404-403 BCE as a case study, in particular the speech of Cleocritus preserved in Xenophon’sHellenica, this paper proposes a new way of thinking about this dual expression of collective life. Far from the reconciliatory reading of Cleocritus’ speech proposed by Loraux, his appeal for harmony bears witness, in the turmoil and tension of events, to the way thatpolitics(in the institutional sense) was sidelined to the exclusive benefit ofthe politicaland the collective practices associated with it. In conclusion, this case study opens up a more general consideration of the meaning of the “event” and its epistemological significance. By considering the crisis of 404-403 BCE at the heart of the “regimes of historicity” that characterized the history of Athens between the fifth and fourth centuries BCE, this article aims to provide a clearer articulation of the foundational moments and established functioning of Greek democracy.
The Single Body of the City: Public Slaves and the Question of the Greek State
Authors: Ismard Paulin 
Published: April 2017

AbstractsPublic slavery was an institution common to most Greek cities during the Classical and Hellenistic periods. Whether they worked on the city’s major construction sites, performed minor duties in its civic administration or filled the ranks of its police force (the famous Scythian archers of classical Athens), public slaves may be said to have constituted the first public servants known to Greek cities. Studying them from this perspective can shed new light on the long-running debate about the degree to which thepolisfunctioned as a state. Direct democracy, in the Classical Athenian sense, implied that all political prerogatives be held by the citizens themselves, and not by any kind of state apparatus. The decision to delegate administrative tasks to slaves can thus be understood as a “resistance” (as defined by the French anthropologist Pierre Clastres) on the part of the civic society to the development of this apparatus.
Capital, Social Reproduction, and the Rise of Inequality
Authors: Spire Alexis 
Published: April 2017

Abstract
Thomas Piketty’s book has the great merit of implementing a global analysis of inequality that compares countries and periods. However, he adopts a definition of social class that overlooks the importance of cultural capital. Furthermore, the role of social movements is relatively marginalized in his account, which also focuses on fiscal tools to the detriment of other forms of regulation. Nonetheless, this innovative and important book opens up new avenues of research in the field of political sociology.
Chronological Depths and the Longue Durée
Authors: Lamouroux Christian 
Published: April 2017

Abstract
This short contribution seeks to place David Armitage and Jo Guldi’s article within a broader historiographical context, enlarged to include the history of China. From the outset, Fernand Braudel was careful to link his vision of the longue durée with the new “area studies” exploring international cultures. By studying social and economic history and more generally by using approaches drawn from the social sciences, European and American specialists of China have deconstructed the overly longue durée of Chinese history and shed light on its dynamism, previously repressed and concealed by the notion of a so-called “civilization.” This process facilitated a successful specialization, which can today be supported by the “big data” being compiled in circles close to the two authors.
Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Authors: Tang HaoRan , Leung Leo , Saturno Grazia , Viros Amaya , Smith Duncan , Di Leva Gianpiero , Morrison Eamonn , Niculescu-Duvaz Dan , Lopes Filipa , Johnson Louise , Dhomen Nathalie , Springer Caroline , Marais Richard 
Published: April 2017

AbstractLysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumour progression. We show that LOX regulates EGFR by suppressing TGFβ1 signalling through the secreted protease HTRA1. This increases the expression of Matrilin2 (MATN2), an EGF-like domain-containing protein that traps EGFR at the cell surface to facilitate its activation by EGF. We describe a pharmacological inhibitor of LOX, CCT365623, which disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumour cells in vivo. Thus, we show that LOX regulates EGFR cell surface retention to drive tumour progression, and we validate the therapeutic potential of inhibiting this pathway with the small molecule inhibitor CCT365623.
Unification of de novo and acquired ibrutinib resistance in mantle cell lymphoma
Authors: Zhao Xiaohong , Lwin Tint , Silva Ariosto , Shah Bijal , Tao Jiangchuan , Fang Bin , Zhang Liang , Fu Kai , Bi Chengfeng , Li Jiannong , Jiang Huijuan , Meads Mark B. , Jacobson Timothy , Silva Maria , Distler Allison , Darville Lancia , Zhang Ling , Han Ying , Rebatchouk Dmitri , Di Liberto Maurizio , Moscinski Lynn C. , Koomen John M. , Dalton William S. , Shain Kenneth H. , Wang Michael , Sotomayor Eduardo , Tao Jianguo 
Published: April 2017

AbstractThe novel Bruton’s tyrosine kinase inhibitor ibrutinib has demonstrated high response rates in B-cell lymphomas; however, a growing number of ibrutinib-treated patients relapse with resistance and fulminant progression. Using chemical proteomics and an organotypic cell-based drug screening assay, we determine the functional role of the tumour microenvironment (TME) in ibrutinib activity and acquired ibrutinib resistance. We demonstrate that MCL cells develop ibrutinib resistance through evolutionary processes driven by dynamic feedback between MCL cells and TME, leading to kinome adaptive reprogramming, bypassing the effect of ibrutinib and reciprocal activation of PI3K-AKT-mTOR and integrin-β1 signalling. Combinatorial disruption of B-cell receptor signalling and PI3K-AKT-mTOR axis leads to release of MCL cells from TME, reversal of drug resistance and enhanced anti-MCL activity in MCL patient samples and patient-derived xenograft models. This study unifies TME-mediated de novo and acquired drug resistance mechanisms and provides a novel combination therapeutic strategy against MCL and other B-cell malignancies.
Dual PI3K and Wnt pathway inhibition is a synergistic combination against triple negative breast cancer
Authors: Solzak Jeffrey P. , Atale Rutuja V. , Hancock Bradley A. , Sinn Anthony L. , Pollok Karen E. , Jones David R. , Radovich Milan 
Published: April 2017

AbstractTriple negative breast cancer accounts for 15–20% of all breast cancer cases, but despite its lower incidence, contributes to a disproportionately higher rate of mortality. As there are currently no Food and Drug Administration-approved targeted agents for triple negative breast cancer, we embarked on a genomic-guided effort to identify novel targeted modalities. Analyses by our group and The Cancer Genome Atlas have identified activation of the PI3K-pathway in the majority of triple negative breast cancers. As single agent therapy is commonly subject to resistance, we investigated the use of combination therapy against compensatory pathways. Herein, we demonstrate that pan-PI3K inhibition in triple negative breast cancers results in marked activation of the Wnt-pathway. Using the combination of two inhibitors currently in clinical trial as single agents, buparlisib(pan-PI3K) and WNT974(WNT-pathway), we demonstrate significant in vitro and in vivo synergy against triple negative breast cancer cell lines and xenografts. Taken together, these observations provide a strong rationale for testing dual targeting of the PI3K and WNT-pathways in clinical trials.
Adaptive quantum state tomography via linear regression estimation: Theory and two-qubit experiment
Authors: Qi Bo , Hou Zhibo , Wang Yuanlong , Dong Daoyi , Zhong Han-Sen , Li Li , Xiang Guo-Yong , Wiseman Howard M. , Li Chuan-Feng , Guo Guang-Can 
Published: April 2017

AbstractAdaptive techniques have great potential for wide application in enhancing the precision of quantum parameter estimation. We present an adaptive quantum state tomography protocol for finite dimensional quantum systems and experimentally implement the adaptive tomography protocol on two-qubit systems. In this adaptive quantum state tomography protocol, an adaptive measurement strategy and a recursive linear regression estimation algorithm are performed. Numerical results show that our adaptive quantum state tomography protocol can outperform tomography protocols using mutually unbiased bases and the two-stage mutually unbiased bases adaptive strategy, even with the simplest product measurements. When nonlocal measurements are available, our adaptive quantum state tomography can beat the Gill–Massar bound for a wide range of quantum states with a modest number of copies. We use only the simplest product measurements to implement two-qubit tomography experiments. In the experiments, we use error-compensation techniques to tackle systematic error due to misalignments and imperfection of wave plates, and achieve about a 100-fold reduction of the systematic error. The experimental results demonstrate that the improvement of adaptive quantum state tomography over nonadaptive tomography is significant for states with a high level of purity. Our results also show that this adaptive tomography method is particularly effective for the reconstruction of maximally entangled states, which are important resources in quantum information.
In vitro developmental ability of ovine oocytes following intracytoplasmic injection with freeze-dried spermatozoa
Authors: Olaciregui Maite , Luño Victoria , Domingo Paula , González Noelia , Gil Lydia 
Published: April 2017

AbstractFreeze-drying (FD) is a new and alternative method to preserve spermatozoa in refrigeration or at room temperature. Suitable protection is required to maintain the sperm DNA integrity during the whole process and storage. The aim of this study was to examine the effect of rosmarinic acid and storage temperature on the DNA integrity of freeze-dried ram sperm. In addition, we evaluated the in vitro developmental ability to the blastocyst stage of oocytes injected with freeze-dried sperm. Ram sperm was freeze-dried in basic medium and in this medium supplemented with 105 µM rosmarinic acid. The vials were stored for 1 year at 4 °C and at room temperature. Frozen sperm was used as control. After rehydration, sperm DNA damage was evaluated, observing that the percentage of spermatozoa with DNA damage decreased significantly in the presence of rosmarinic acid, without differences between the two storage temperatures. Moreover, no differences were observed between the freeze-dried group and the frozen-thawed group in terms of blastocyst formation rate. We proved for the first time that ovine spermatozoa can be lyophilized effectively, stored at room temperature for long term, reconstituted and further injected into oocytes with initial embryo development.
3D Microfluidic model for evaluating immunotherapy efficacy by tracking dendritic cell behaviour toward tumor cells
Authors: Parlato Stefania , De Ninno Adele , Molfetta Rosa , Toschi Elena , Salerno Debora , Mencattini Arianna , Romagnoli Giulia , Fragale Alessandra , Roccazzello Lorenzo , Buoncervello Maria , Canini Irene , Bentivegna Enrico , Falchi Mario , Bertani Francesca Romana , Gerardino Annamaria , Martinelli Eugenio , Natale Corrado , Paolini Rossella , Businaro Luca , Gabriele Lucia 
Published: April 2017

AbstractImmunotherapy efficacy relies on the crosstalk within the tumor microenvironment between cancer and dendritic cells (DCs) resulting in the induction of a potent and effective antitumor response. DCs have the specific role of recognizing cancer cells, taking up tumor antigens (Ags) and then migrating to lymph nodes for Ag (cross)-presentation to naïve T cells. Interferon-α-conditioned DCs (IFN-DCs) exhibit marked phagocytic activity and the special ability of inducing Ag-specific T-cell response. Here, we have developed a novel microfluidic platform recreating tightly interconnected cancer and immune systems with specific 3D environmental properties, for tracking human DC behaviour toward tumor cells. By combining our microfluidic platform with advanced microscopy and a revised cell tracking analysis algorithm, it was possible to evaluate the guided efficient motion of IFN-DCs toward drug-treated cancer cells and the succeeding phagocytosis events. Overall, this platform allowed the dissection of IFN-DC-cancer cell interactions within 3D tumor spaces, with the discovery of major underlying factors such as CXCR4 involvement and underscored its potential as an innovative tool to assess the efficacy of immunotherapeutic approaches.
Silicon amendment to rice plants impairs sucking behaviors and population growth in the phloem feeder Nilaparvata lugens (Hemiptera: Delphacidae)
Authors: Yang Lang , Han Yongqiang , Li Pei , Wen Lizhang , Hou Maolin 
Published: April 2017

AbstractThe brown planthopper (BPH), Nilaparvata lugens (Stål), is a migratory and destructive sucking insect pest of rice. Silicon (Si) amendment to plants can confer enhanced resistance to herbivores and is emerging as a novel approach for pest management. In the present study, we tested the effects of Si addition at 0.16 (low) and 0.32 (high) g Si/kg soil on sucking behaviors and population growth in BPH. Si amendment increased Si content in rice stems and extended non-probing event and phloem puncture followed by sustained phloem ingestion over that in the no-Si-addition control. High Si addition rate prolonged the stylet pathway and the time needed to reach the first phloem puncture, shortened durations of phloem puncture and phloem ingestion, and decreased the proportion of individuals that produced sustained phloem ingestion. BPH female feeding on and preference for plants with the high Si addition rate were also reduced. As a result, Si application significantly decreased BPH population growth rates while increased population doubling time. These results indicate that Si amendment, especially at the high rate, confers enhanced rice plant resistance to BPH through impairment of BPH feeding. Our results highlight the potential of Si amendment as an alternative for BPH management.
Switch from ambient to focal processing mode explains the dynamics of free viewing eye movements
Authors: Ito Junji , Yamane Yukako , Suzuki Mika , Maldonado Pedro , Fujita Ichiro , Tamura Hiroshi , Grün Sonja 
Published: April 2017

AbstractPrevious studies have reported that humans employ ambient and focal modes of visual exploration while they freely view natural scenes. These two modes have been characterized based on eye movement parameters such as saccade amplitude and fixation duration, but not by any visual features of the viewed scenes. Here we propose a new characterization of eye movements during free viewing based on how eyes are moved from and to objects in a visual scene. We applied this characterization to data obtained from freely-viewing macaque monkeys. We show that the analysis based on this characterization gives a direct indication of a behavioral shift from ambient to focal processing mode along the course of free viewing exploration. We further propose a stochastic model of saccade sequence generation incorporating a switch between the two processing modes, which quantitatively reproduces the behavioral features observed in the data.
Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases
Authors: Fukuzawa Taku , Sampei Zenjiro , Haraya Kenta , Ruike Yoshinao , Shida-Kawazoe Meiri , Shimizu Yuichiro , Gan Siok Wan , Irie Machiko , Tsuboi Yoshinori , Tai Hitoshi , Sakiyama Tetsushi , Sakamoto Akihisa , Ishii Shinya , Maeda Atsuhiko , Iwayanagi Yuki , Shibahara Norihito , Shibuya Mitsuko , Nakamura Genki , Nambu Takeru , Hayasaka Akira , Mimoto Futa , Okura Yuu , Hori Yuji , Habu Kiyoshi , Wada Manabu , Miura Takaaki , Tachibana Tatsuhiko , Honda Kiyofumi , Tsunoda Hiroyuki , Kitazawa Takehisa , Kawabe Yoshiki , Igawa Tomoyuki , Hattori Kunihiro , Nezu Junichi 
Published: April 2017

AbstractDysregulation of the complement system is linked to the pathogenesis of a variety of hematological disorders. Eculizumab, an anti-complement C5 monoclonal antibody, is the current standard of care for paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). However, because of high levels of C5 in plasma, eculizumab has to be administered biweekly by intravenous infusion. By applying recycling technology through pH-dependent binding to C5, we generated a novel humanized antibody against C5, SKY59, which has long-lasting neutralization of C5. In cynomolgus monkeys, SKY59 suppressed C5 function and complement activity for a significantly longer duration compared to a conventional antibody. Furthermore, epitope mapping by X-ray crystal structure analysis showed that a histidine cluster located on C5 is crucial for the pH-dependent interaction with SKY59. This indicates that the recycling effect of SKY59 is driven by a novel mechanism of interaction with its antigen and is distinct from other known pH-dependent antibodies. Finally, SKY59 showed neutralizing effect on C5 variant p.Arg885His, while eculizumab does not inhibit complement activity in patients carrying this mutation. Collectively, these results suggest that SKY59 is a promising new anti-C5 agent for patients with PNH and other complement-mediated disorders.
Unravelling the drastic range retraction of an emblematic songbird of North Africa: potential threats to Afro-Palearctic migratory birds
Authors: Khelifa Rassim , Zebsa Rabah , Amari Hichem , Mellal Mohammed Khalil , Bensouilah Soufyane , Laouar Abdeldjalil , Mahdjoub Hayat 
Published: April 2017

AbstractUnderstanding how culture may influence biodiversity is fundamental to ensure effective conservation, especially when the practice is local but the implications are global. Despite that, little effort has been devoted to documenting cases of culturally-related biodiversity loss. Here, we investigate the cultural domestication of the European goldfinch (Carduelis carduelis) in western Maghreb (Morocco, Algeria and Tunisia) and the effects of long-term poaching of wild populations (1990–2016) on range distribution, socio-economic value, international trading and potential collateral damage on Afro-Palearctic migratory birds. On average, we found that the European goldfinch lost 56.7% of its distribution range in the region which led to the increase of its economic value and establishment of international trading network in western Maghreb. One goldfinch is currently worth nearly a third of the average monthly income in the region. There has been a major change in poaching method around 2010, where poachers started to use mist nets to capture the species. Nearly a third of the 16 bird species captured as by-catch of the European goldfinch poaching are migratory, of which one became regularly sold as cage-bird. These results suggest that Afro-Palearctic migratory birds could be under serious by-catch threat.
Electron-phonon coupling in topological surface states: The role of polar optical modes
Authors: Heid Rolf , Sklyadneva Irina Yu. , Chulkov Evgueni V. 
Published: April 2017

AbstractThe use of topological edge states for spintronic applications could be severely hampered by limited lifetimes due to intrinsic many-body interactions, in particular electron-phonon coupling. Previous works to determine the intrinsic coupling strength did not provide a coherent answer. Here, the electron-phonon interaction in the metallic surface state of 3D topological insulators is revised within a first principles framework. For the archetypical cases of Bi2Se3 and Bi2Te3, we find an overall weak coupling constant of less than 0.15, but with a characteristic energy dependence. Derived electronic self-energies compare favorably with previous angle-resolved photoemission spectroscopy results. The prevailing coupling is carried by optical modes of polar character, which is weakly screened by the metallic surface state and can be reduced by doping into bulk bands. We do not find any indication of a strong coupling to the A1g
mode or the presence of a Kohn anomaly in the surface phonon spectrum. The weak intrinsic electron-phonon coupling guarantees long-lived quasiparticles at elevated temperatures.