bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross-continental comparison of plant reproductive phenology shows high intraspecific variation in temperature sensitivity
Authors: Reeb Rachel A , Heberling J Mason , Kuebbing Sara E 
Published: October 2024

Abstract
The success of plant species under climate change will be determined, in part, by their phenological responses to temperature. Despite the growing need to forecast such outcomes across entire species ranges, it remains unclear how phenological sensitivity to temperature might vary across individuals of the same species. In this study, we harnessed community science data to document intraspecific patterns in phenological temperature sensitivity across the multicontinental range of six herbaceous plant species. Using linear models, we correlated georeferenced temperature data with 23 220 plant phenological records from iNaturalist to generate spatially explicit estimates of phenological temperature sensitivity across the shared range of species. We additionally evaluated the geographic association between local historic climate conditions (i.e. mean annual temperature [MAT] and interannual variability in temperature) and the temperature sensitivity of plants. We found that plant temperature sensitivity varied substantially at both the interspecific and intraspecific levels, demonstrating that phenological responses to climate change have the potential to vary both within and among species. Additionally, we provide evidence for a strong geographic association between plant temperature sensitivity and local historic climate conditions. Plants were more sensitive to temperature in hotter climates (i.e. regions with high MAT), but only in regions with high interannual temperature variability. In regions with low interannual temperature variability, plants displayed universally weak sensitivity to temperature, regardless of baseline annual temperature. This evidence suggests that pheno-climatic forecasts may be improved by accounting for intraspecific variation in phenological temperature sensitivity. Broad climatic factors such as MAT and interannual temperature variability likely serve as useful predictors for estimating temperature sensitivity across species’ ranges.
Indocyanine Green Angiography–Assisted Pure Hemi-periareolar Incision Nipple-Sparing Mastectomy and Direct-to-Implant Breast Reconstruction
Authors: Lee Mi Kyung , Kang Jung-min , Lim Woo Sung , Park Jin-Woo , Woo Kyong-Je 
Published: October 2024

Abstract

Background
Although pure hemi-periareolar incisions for mastectomy can prevent visible scarring, nipple-areolar complex (NAC) necrosis is a potential risk. Superficial-arterial inflow of the NAC can be evaluated by indocyanine green angiography (ICG-A).

Objectives
This study evaluated the impact of ICG-A–assisted periareolar incision on NAC necrosis during nipple-sparing mastectomy (NSM) and direct-to-implant (DTI) breast reconstruction.

Methods
Between December 2018 and November 2021, lateral hemi-periareolar incisions for NSM were routine. After that time, ICG-A–assisted hemi-periareolar incisions were performed between December 2021 and September 2023. The location of the main arterial inflow was evaluated during preoperative ICG-A and the periareolar incision was planned to avoid disruption. NAC necrosis in the ICG-A–assisted and blind-incision groups was compared by univariate and multivariate analyses.

Results
A total of 202 breasts were analyzed, comprising 80 breasts from 75 patients in the ICG-A–assisted group and 122 breasts from 115 patients in the blind-incision group. On preoperative ICG-A, superficial-arterial inflow was observed in 67 of 80 (83.75%) breasts. Perfusion of the nipple without superficial-arterial inflow (base-perfusion pattern) was observed in 13 breasts (16.25%). The main arterial inflow was most common in the upper-medial direction at the areolar margins (65.67%). The full-thickness NAC necrosis rate in the ICG-A–assisted incision group was significantly lower than that in the blind-incision group (2.5% vs 13.1%, P = .010). Multivariate analysis demonstrated that ICG-A–assisted incisions significantly reduced the risk of NAC necrosis (odds ratio, 0.155; P = .030).

Conclusions
ICG-A–assisted pure hemi-periareolar incisions reduced NAC necrosis in DTI breast reconstructions.

Level of Evidence: 3 (Therapeutic)
Cross-population enhancement of PrediXcan predictions with a gnomAD-based east Asian reference framework
Authors: Chan Han-Ching , Chattopadhyay Amrita , Lu Tzu-Pin 
Published: October 2024

Abstract
Over the past decade, genome-wide association studies have identified thousands of variants significantly associated with complex traits. For each locus, gene expression levels are needed to further explore its biological functions. To address this, the PrediXcan algorithm leverages large-scale reference data to impute the gene expression level from single nucleotide polymorphisms, and thus the gene-trait associations can be tested to identify the candidate causal genes. However, a challenge arises due to the fact that most reference data are from subjects of European ancestry, and the accuracy and robustness of predicted gene expression in subjects of East Asian (EAS) ancestry remains unclear. Here, we first simulated a variety of scenarios to explore the impact of the level of population diversity on gene expression. Population differentiated variants were estimated by using the allele frequency information from The Genome Aggregation Database. We found that the weights of a variants was the main factor that affected the gene expression predictions, and that ~70% of variants were significantly population differentiated based on proportion tests. To provide insights into this population effect on gene expression levels, we utilized the allele frequency information to develop a gene expression reference panel, Predict Asian-Population (PredictAP), for EAS ancestry. PredictAP can be viewed as an auxiliary tool for PrediXcan when using genotype data from EAS subjects.
Target controllability: a feed-forward greedy algorithm in complex networks, meeting Kalman’s rank condition
Authors: Khezri Seyedeh Fatemeh , Ebrahimi Ali , Eslahchi Changiz 
Published: October 2024

Abstract

Motivation
The concept of controllability within complex networks is pivotal in determining the minimal set of driver vertices required for the exertion of external signals, thereby enabling control over the entire network’s vertices. Target controllability further refines this concept by focusing on a subset of vertices within the network as the specific targets for control, both of which are known to be NP-hard problems. Crucially, the effectiveness of the driver set in achieving control of the network is contingent upon satisfying a specific rank condition, as introduced by Kalman. On the other hand, structural controllability provides a complementary approach to understanding network control, emphasizing the identification of driver vertices based on the network’s structural properties. However, in structural controllability approaches, the Kalman condition may not always be satisfied.

Results
In this study, we address the challenge of target controllability by proposing a feed-forward greedy algorithm designed to efficiently handle large networks while meeting the Kalman controllability rank condition. We further enhance our method’s efficacy by integrating it with Barabasi et al.’s structural controllability approach. This integration allows for a more comprehensive control strategy, leveraging both the dynamical requirements specified by Kalman’s rank condition and the structural properties of the network. Empirical evaluation across various network topologies demonstrates the superior performance of our algorithms compared to existing methods, consistently requiring fewer driver vertices for effective control. Additionally, our method’s application to protein–protein interaction networks associated with breast cancer reveals potential drug repurposing candidates, underscoring its biomedical relevance. This study highlights the importance of addressing both structural and dynamical aspects of network controllability for advancing control strategies in complex systems.

Availability and implementation
The source code is available for free at:Https://github.com/fatemeKhezry/targetControllability.
Application and integration of computer vision technologies for automated recognition and recording of chemical experiments
Authors: Sasaki Ryosuke , Fujinami Mikito , Nakai Hiromi 
Published: October 2024

Abstract
Advancements in computer vision have significantly improved motion and object recognition accuracy. These advancements should aid the automatic recognition of chemical experiments, potentially contributing to the recording of experiments. Creating an electronic laboratory notebook from experiment filming enhances convenience and allows more detailed information storage compared to traditional manual recording methods. Our previous research focused on employing object detection and action recognition to automate the recognition of chemical experiments. This paper presents a novel system that combines object detection, action recognition, multiple object tracking, and barcode recognition to automatically generate experimental flowcharts. We implemented our system as a graphical user interface-based application for laboratory use that successfully constructs flowcharts from videos of chemical experiments, including simple chemical manipulations.
Transnational networks of energy communities as counterpower in the European Union renewable energy transition framework
Authors: Esteves Ana Margarida , de Brito e Cunha Felipe Berlinski , Girardi André de Freitas , Quintão Felipe 
Published: October 2024

Abstract
This article explores the communicative process by which transnational networks of energy communities (ECs) in Europe build counterpower vis-a-vis the European Union (EU) institutional framework, with the purpose of effectively contributing to the shaping and management of the EU policy and regulatory framework for renewable energy transition. Such a process consists in the identification of obstacles to effective participation, the facilitation of access to information on EU regulation and policy frameworks, and the production of technical knowledge that reframes how renewable energy transition is understood as a field of political intervention. The impact of EC networks, and other networks of related community-led initiatives, on the EU energy policy framework is still relatively small when compared to centralized, large-scale providers of energy. It is constrained by how differently EU regulatory and policy packages address ‘techno-energetic systems’ in energy transition, as well as disparities in the transposition of EU legislation by Member States. Still, EC networks are building counterpower by facilitating bottom-up information and skill sharing, focusing on facilitating access to information on EU regulation and policy frameworks, as well as producing knowledge that frames the obstacles to effective participation of ECs in policymaking. It expands the understanding of renewable energy transition as a field of policy intervention beyond merely instrumental logic, centred on regulation and policy support to technological innovation, by mainstreaming a substantive logic based on a comprehensive socioecological framing that embeds energy transition in a multidimensional understanding of territorial development and governance.
Strategic approaches to observing 39K NMR signals from potassium–graphite intercalation compounds
Authors: Ando Hideka , Hashi Kenjiro , Ohki Shinobu , Matsumoto Rika , Gotoh Kazuma 
Published: October 2024

Abstract
Solid-state nuclear magnetic resonance is an invaluable tool for potassium–graphite intercalation compounds, promising anode materials of K-ion batteries, but it has not yet been applied because of several issues. We attempted 39K NMR measurements of potassium–graphite intercalation compounds sealed in glass using an 18.8 T NMR spectrometer with a nuclear magnetic resonance probe adjusted to the samples. The first observed 39K NMR signal of potassium–graphite intercalation compounds showed the possibility of evaluating intralayer density, which cannot be ascertained from Raman measurements.
Comparative Safety of Different Antibiotic Regimens for the Treatment of Outpatient Community-Acquired Pneumonia Among Otherwise Healthy Adults
Authors: Butler Anne M , Nickel Katelin B , Olsen Margaret A , Sahrmann John M , Colvin Ryan , Neuner Elizabeth , O’Neil Caroline A , Fraser Victoria J , Durkin Michael J 
Published: October 2024

Abstract

Background
Evidence is limited on the comparative safety of antibiotic regimens for treatment of community-acquired pneumonia (CAP). We compared the risk of adverse drug events (ADEs) associated with antibiotic regimens for CAP treatment among otherwise healthy, nonelderly adults.

Methods
We conducted an active-comparator new-user cohort study (2007–2019) of commercially insured adults aged 18–64 years diagnosed with outpatient CAP, evaluated via chest X-ray, and dispensed a same-day CAP-related oral antibiotic regimen. ADE follow-up duration ranged from 2 to 90 days (eg, renal failure [14 days]). We estimated risk differences [RDs] per 1000 treatment episodes and risk ratios using propensity score–weighted Kaplan-Meier functions. Ankle/knee sprain and influenza vaccination were considered as negative control outcomes.

Results
Of 145 137 otherwise healthy CAP patients without comorbidities, 52% received narrow-spectrum regimens (44% macrolide, 8% doxycycline) and 48% received broad-spectrum regimens (39% fluoroquinolone, 7% β-lactam, 3% β-lactam + macrolide). Compared with macrolide monotherapy, each broad-spectrum antibiotic regimen was associated with increased risk of several ADEs (eg, β-lactam: nausea/vomiting/abdominal pain [RD per 1000, 3.20; 95% CI, 0.99–5.73]; non–Clostridioides difficile diarrhea [RD per 1000, 4.61; 95% CI, 2.47–6.82]; vulvovaginal candidiasis/vaginitis [RD per 1000, 3.57; 95% CI, 0.87, 6.88]). Narrow-spectrum antibiotic regimens largely conferred similar risk of ADEs. We generally observed similar risks of each negative control outcome, indicating minimal confounding.

Conclusions
Broad-spectrum antibiotics were associated with increased risk of ADEs among otherwise healthy adults treated for CAP in the outpatient setting. Antimicrobial stewardship is needed to promote judicious use of broad-spectrum antibiotics and ultimately decrease antibiotic-related ADEs.
Deep learning improves test–retest reproducibility of regional strain in echocardiography
Authors: Nyberg John , Østvik Andreas , Salte Ivar M , Olaisen Sindre , Karlsen Sigve , Dahlslett Thomas , Smistad Erik , Eriksen-Volnes Torfinn , Brunvand Harald , Edvardsen Thor , Haugaa Kristina H , Lovstakken Lasse , Dalen Havard , Grenne Bjørnar 
Published: October 2024

Abstract

Aims
The clinical utility of regional strain measurements in echocardiography is challenged by suboptimal reproducibility. In this study, we aimed to evaluate the test–retest reproducibility of regional longitudinal strain (RLS) per coronary artery perfusion territory (RLSTerritory) and basal-to-apical level of the left ventricle (RLSLevel), measured by a novel fully automated deep learning (DL) method based on point tracking.

Methods and results
We measured strain in a dual-centre test–retest data set that included 40 controls and 40 patients with suspected non-ST elevation acute coronary syndrome. Two consecutive echocardiograms per subject were recorded by different operators. The reproducibility of RLSTerritory and RLSLevel measured by the DL method and by three experienced observers using semi-automatic software (2D Strain, EchoPAC, GE HealthCare) was evaluated as minimal detectable change (MDC). The DL method had MDC for RLSTerritory and RLSLevel ranging from 3.6 to 4.3%, corresponding to a 33–35% improved reproducibility compared with the inter- and intraobserver scenarios (MDC 5.5–6.4% and 4.9–5.4%). Furthermore, the DL method had a lower variance of test–retest differences for both RLSTerritory and RLSLevel compared with inter- and intraobserver scenarios (all P &lt; 0.001). Bland–Altman analyses demonstrated superior reproducibility by the DL method for the whole range of strain values compared with the best observer scenarios. The feasibility of the DL method was 93% and measurement time was only 1 s per echocardiogram.

Conclusion
The novel DL method provided fully automated measurements of RLS, with improved test–retest reproducibility compared with semi-automatic measurements by experienced observers. RLS measured by the DL method has the potential to advance patient care through a more detailed, more efficient, and less user-dependent clinical assessment of myocardial function.
All-cause and cause-specific mortality among older migrant and non-migrant adults in Finland: a register study on all deaths, 2002–2020
Authors: Kemppainen Laura , Kemppainen Teemu , Raitanen Jani , Aaltonen Mari , Forma Leena , Kouvonen Anne , Pulkki Jutta 
Published: October 2024

Abstract
Migrant mortality advantage is established in various studies, but there is a lack of evidence on migrant mortality trends in old age. Previous studies have primarily concentrated on all-cause mortality, and few include older age groups. Discussions about the migrant mortality advantage continue due to concerns about data availability and accuracy. Additionally, the mechanisms explaining the migrant mortality advantage remain unclear. This study examines all-cause and cause-specific mortality among older migrant and nonmigrant adults aged 70 and above using Finnish Cause of Death register data (2002–20) and the corresponding risk population. We investigate differences in overall and cause-specific mortality between migrant and Finnish-born population and by geographical region of origin. We calculated direct age-standardized mortality rates and age group-specific death rates followed by Poisson regression to study relative mortality differences. Age at death, sex, income, region of residence, and year of death were controlled for in the regression analysis. We found evidence of migrant mortality advantage across various causes of death, but there was variation by regions of origin groups and sex. Notably, women exhibit the strongest advantage in respiratory and digestive system diseases, while men demonstrated pronounced advantages in external causes and respiratory diseases. Our study challenges the notion of a general diminishing healthy migrant effect in old age. Our findings emphasize the need for nuanced investigations into socioeconomic factors and tailored interventions for older migrants.
Anisogamy and sex roles: a commentary
Authors: Mokos Judit , Scheuring István , Liker András , Freckleton Robert P , Székely Tamás 
Published: October 2024

Abstract
The origin and maintenance of sex differences in reproductive behavior (often labeled sex roles) have remained controversial topics, and recent meta-analyses and theoretical models have helped to elucidate the processes that generate diverse sex roles. We are glad to see that our study (Mokos et al., 2021) generated a healthy debate, and in agreement with recent commentaries (Janicke, 2024; Lehtonen & Parker, 2024) we call for a more comprehensive approach to understanding sex role evolution.
Increased spending on low-value care during the COVID-19 pandemic in Virginia
Authors: Rockwell Michelle S , Vangala Sitaram , Rider Jillian , Bortz Beth , Russell Kyle , Dachary Marcos , Walker Lauryn , Fendrick A Mark , Mafi John N 
Published: October 2024

Abstract
Characterizing the value and equity of care delivered during the COVID-19 pandemic is crucial to uncovering health system vulnerabilities and informing postpandemic recovery. We used insurance claims to evaluate low-value (no clinical benefit, potentially harmful) and clinically indicated utilization of a subset of 11 ambulatory services within a cohort of ∼2 million Virginia adults during the first 2 years of the pandemic (March 1, 2020–December 31, 2021). In 2020, low-value and clinically indicated utilization decreased similarly, while in 2021, low-value and clinically indicated utilization were 7% higher and 4% lower, respectively, than prepandemic rates. Extrapolated to Virginia's population of insured adults, ∼$1.3 billion in spending was associated with low-value utilization of the 11 services during the study period, with 2021 spending rates 6% higher than prepandemic rates. During March 1, 2020–December 31, 2021, low-value and clinically indicated utilization were 15% and 16% lower, respectively, than pre-pandemic rates among patients with the greatest socioeconomic deprivation but similar to prepandemic rates among patients with the least socioeconomic deprivation. These results highlight widening healthcare disparities and underscore the need for policy-level efforts to address the complex drivers of low-value care and equitably redistribute expenditures to services that enhance health.
The scion-driven transcriptomic changes guide the resilience of grafted near-isohydric grapevines under water deficit
Authors: Rodriguez-Izquierdo Alberto , Carrasco David , Valledor Luis , Bota Josefina , López-Hidalgo Cristina , Revilla Maria A , Arroyo-Garcia Rosa 
Published: October 2024

Abstract
The large diversity of grapevine cultivars includes genotypes more tolerant to water deficit than others. Widely distributed cultivars, like Merlot, are more sensitive to water deprivation than local cultivars like Callet, which are more adapted to water deficit due to their Mediterranean origin. Despite their tolerance, adaptation to water deficit influenced by grafting in rootstocks like 110 Richter is key to facing drought in vineyards, defining the scion–rootstock relationship. To understand these differences, we explored transcriptomic, metabolic, hormonal and physiological responses under three levels of water deficit (mild, high, and extreme), using 110 Richter as the rootstock in both cultivars. Results revealed that sensitivity to abscisic acid (ABA) is essential for water deficit tolerance in the aerial part, guiding root responses. Callet/110 Richter activates more gene expression patterns in response to ABA, reducing water loss compared to Merlot/110 Richter in both aerial and root parts. This modulation in Callet/110 Richter involves regulating metabolic pathways to increase cell turgor, reducing photosynthesis, and producing molecules like polyphenols or flavonoids to respond to oxidative stress. In contrast, Merlot/110 Richter shows a lack of specific response, especially in the roots, indicating less resilience to water stress. Therefore, selecting genotypes more sensitive to ABA and their interaction with rootstocks is key for managing vineyards in future climate change scenarios.
Tracing competencies and product requirements in technology space: a new perspective on firm and industry evolution
Authors: Metzler Florian 
Published: October 2024

Abstract
This paper combines a resource-based perspective with a dynamic, evolutionary perspective to study firm and industry evolution. The technological competencies of firms and the technological requirements of products are projected onto a map of technology space where respective positions can be studied as a function of time. The potential of the developed approach is demonstrated by shedding new light on the mobile phone industry from 1993 to 2012, comparing new entrants Apple and Google with incumbents Ericsson, Motorola, Nokia, and RIM. Findings highlight the importance of firms’ abilities to orient and situate themselves in their dynamic environments and to recognize and act upon opportunities and threats that result from evolving technological supply and demand.