bluuebunny/crossref_metadata_2025_split huggingface dataset:
CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells
Authors: Ueshima Chiyuki , Kataoka Tatsuki R. , Takei Yusuke , Hirata Masahiro , Sugimoto Akihiko , Hirokawa Mitsuyoshi , Okayama Yoshimichi , Blumberg Richard S. , Haga Hironori 
Published: March 2017

AbstractCarcinoembryonic antigen‐related cell adhesion molecule 1 (CEACAM1) is expressed in a number of tumor cell types. The immunoreceptor tyrosine‐based inhibitory motif (ITIM)‐containing isoforms of this molecule which possess a long cytoplasmic tail (CEACAM1‐L) generally play inhibitory roles in cell function by interacting with Src homology 2 domain‐containing tyrosine phosphatase (SHP)‐1 and/or SHP‐2. Src family kinases (SFKs) are also known to bind to and phosphorylate CEACAM1‐L isoforms. Here, we report that CEACAM1 was uniquely expressed at high levels in both human neoplastic mast cells (mastocytosis) and medullary thyroid carcinoma cell (MTC) lines, when compared with their expression in nonneoplastic mast cells or nonneoplastic C cells. This expression was mainly derived from CEACAM1‐L isoforms based upon assessment of CEACAM1 mRNA expression. CEACAM1 knockdown upregulated cell growth of HMC1.2 cells harboring KIT mutations detected in clinical mastocytosis, whereas downregulated the growth of TT cells harboring RET mutations detected in clinical MTCs. Immunoblotting, ELISA and immunoprecipitaion analysis showed that activated SHP‐1 is preferentially associated with CEACAM1 in HMC1.2 cells harboring KIT mutations, whereas Src family kinases (SFKs) are preferentially associated with CEACAM1 in TT cells harboring RET mutations. These studies suggest that the dominantly interacting proteins SHP1 or SFK determine whether CEACAM1‐L displays a positive or negative role in tumor cells.
Secondary school counselling supervision and the impact of the work environment
Authors: Harries Imogen , Spong Sheila 
Published: March 2017

AbstractAimsThe purpose of this study was to investigate how the secondary school as a working environment for counsellors in the South West of England impacted on what they required from their supervision.MethodSeven experienced school counsellors participated in semi‐structured interviews. Participants all had worked for at least 1 year as a school counsellor (m = 4.7), and had been qualified as a counsellor for at least 1 year (m = 7). Methods of analysing interview transcripts were heavily influenced by grounded theory.FindingsOne core concept (‘The counsellor as part of a system’) linked five main themes (‘the ‘context’ and ‘content’’, ‘separation of roles’, ‘boundaries and confidentialities’, ‘the goals of the environment’, and ‘managing risk’). Counsellors identified four main requirements from their supervisors: a need to be external to the school, a knowledge and understanding of risk and child protection legislation, an understanding of the working context of the counsellor and how that impacts on their work, and a knowledge of how to work therapeutically with this age group.ConclusionFindings indicated that school counsellors do have specific needs from supervision in order to fulfil their therapeutic role within secondary schools. This has important implications for supervisors and trainers. More nationwide research is recommended in this area of supervision, as well as the supervisory needs of school counsellors in primary schools.
Gender‐based outcomes of bivalirudin versus heparin in patients undergoing percutaneous coronary interventions: Meta‐analysis of randomized controlled trials
Authors: Mina George S. , Firouzbakht Tina , Modi Kalgi , Dominic Paari 
Published: March 2017

ObjectivesWe aimed to perform a gender‐based meta‐analysis of the outcome of bivalirudin versus heparin in patients undergoing percutaneous coronary interventions (PCI).BackgroundBivalirudin has been shown to decrease major bleeding when compared to heparin ± glycoprotein IIb/IIIa inhibitors (GPI) in patients undergoing PCI. It is unclear, however, if those differences in outcomes are the same for men and women.MethodsWe included randomized controlled trials (RCTs) that compared bivalirudin to heparin with or without GPI in patients undergoing PCI and reported outcome data that were stratified by gender. Random effect model was used to pool odds ratio (OR) and 95% confidence intervals (CI).ResultsWe included 9 trials with 33,224 patients. Bivalirudin decreased major bleeding when compared to heparin plus routine GPI in both men (OR: 0.51, P < 0.001) and women (OR: 0.55, P < 0.001). However, when GPI were used selectively with heparin, the bleeding lowering effect of bivalirudin was statistically significant in men (OR: 0.69, P = 0.02) but not in women (OR: 0.71, P = 0.21). When compared to heparin ± GPI, there was a nonstatistically significant trend toward lower all‐cause mortality with bivalirudin in both men (OR: 0.76, P = 0.055) and women (OR: 0.79, P = 0.21). There were no significant differences in major adverse cardiovascular events between heparin and bivalirudin in both men and women.ConclusionBivalirudin decreases major bleeding in both men and women when compared to heparin plus routine GPI. However, when compared to heparin alone, the bleeding lowering benefit of bivalirudin is less evident in women. © 2017 Wiley Periodicals, Inc.
Management strategies for severe aortic stenosis and coronary artery disease in the transcatheter aortic valve implantation era
Authors: Mahmood M. M. , Muir D. F. 
Published: March 2017

AbstractCoronary artery disease (CAD) and aortic stenosis (AS) frequently coexist. The advent of transcatheter aortic valve implantation (TAVI) and its increased use over the last decade has brought a paradigm shift in the management of patients with severe AS who are considered inoperable or high risk for sAVR. The most appropriate management of coexistent CAD in patients undergoing TAVI is yet to be defined. In this article, we present a review of the issues arising in the management of CAD in patients with severe AS—with particular reference to those who are undergoing TAVI.Answer questions and earn CME: https://wileyhealthlearning.com/Activity2/5222680/Activity.aspx
Three‐Dimensional Probing of Catalyst Ageing on Different Length Scales: A Case Study of Changes in Microstructure and Activity for CO Oxidation of a Pt–Pd/Al2O3 Catalyst
Authors: Nilsson Pingel Torben , Fouladvand Sheedeh , Heggen Marc , Dunin‐Borkowski Rafal E. , Jäger Wolfgang , Westenberger Peter , Phifer Daniel , McNeil Jace , Skoglundh Magnus , Grönbeck Henrik , Olsson Eva 
Published: March 2017

AbstractThe effects of thermal treatment on the microstructure of a Pt–Pd/Al2O3 oxidation catalyst and its activity for CO oxidation have been studied. The microstructural analysis was performed by using several high‐resolution electron microscopy techniques such as STEM, FIB/SEM slice & view, SEM and EDX. A combination of these analytic techniques and advanced TEM specimen preparation allowed for three‐dimensional probing at different length scales, avoiding the random character of conventionally crushed powder specimens owing to site specificity. A core–shell distribution of Pt–Pd nanoparticles within the alumina support particles, with enlarged nanoparticles (≈1.5 to 40 nm) present in the shell and small nanoparticles (<1.5 nm) in the core, was revealed in the untreated catalyst. A more uniform spatial distribution developed during thermal treatment at 700 °C or higher with larger nanoparticles forming in the core. Accompanying measurements of the catalytic activity for CO oxidation showed the detrimental effect of sintering of the small nanoparticles on the reaction rate and apparent activation energy of the reaction.
Influence of the Transition‐Metal Fragment on the Reactivity of Metallaanthracenes
Authors: García‐Rodeja Yago , Fernández Israel 
Published: March 2017

AbstractThe influence of the nature of the transition‐metal fragment on the Diels–Alder reactivity of metallaanthracenes has been explored computationally within the Density Functional Theory framework. It is found that the cycloaddition reactions with maleic anhydride become kinetically less favored for those processes involving metallaanthracenes compared with the analogous reaction involving the parent anthracene. The origins of this reduction in the Diels–Alder reactivity have been quantitatively analyzed in detail by using the activation strain model of reactivity in combination with the energy decomposition analysis method. In general, the transition‐metal fragment makes the interaction energy between the reactants significantly lower, particularly at the transition state region, which is translated into a higher activation barrier. In addition, the influence of the aromaticity strength of the metallabenzene present in the considered metallaanthracenes on the barriers of the cycloaddition reactions has also been assessed.
Ceric Cyclopentadienides Bearing Alkoxy, Aryloxy, Chlorido, or Iodido Co‐Ligands
Authors: Schneider David , Harmgarth Nicole , Edelmann Frank T. , Anwander Reiner 
Published: March 2017

AbstractA series of heteroleptic tris(cyclopentadienyl) CeIV complexes has been isolated and crystallographically characterized, revealing the broad accessibility of such organocerium(IV) compounds. The oxidation of complexes CpMe3Ce(thf) and Cp′3Ce(thf) (CpMe=C5H4Me, Cp′=C5H4SiMe3), bearing monosubstituted electron‐poor cyclopentadienyl ligands, with 0.5 equivalents of 1,4‐benzoquinone or C2Cl6 gave the cerium(IV) hydroquinolate complexes CpMe3Ce(OC6H4O)CeCpMe3 and Cp′3Ce(OC6H4O)CeCp′3, or the chloride complexes CpMe3CeCl and Cp′3CeCl, respectively; the iodide complex Cp′3CeI was obtained from the reaction of Cp′3Ce(thf) with elemental iodine. The behavior of Cp′3CeCl in salt metathesis protocols employing alkali metal amides or alkyl, alkoxide, and aryloxide reagents was investigated, which gave rise to the robust and isolable cerium(IV) alkoxide Cp′3Ce(OtBu). Trivalent [Cp′2CeCl]2 was synthesized by AlMe4→Cl exchange utilizing Cp′2Ce(AlMe4) and AlMe2Cl. The reactivity of [Cp′2CeCl]2 towards the oxidants Ph3CCl, C2Cl6, 1,4‐benzoquinone, and I2 has been assessed, and has provided useful information on CeIII/CeIV redox deactivation pathways. In addition to X‐ray structure analysis, all the complexes were characterized by NMR, DRIFT (diffuse reflectance IR Fourier transform), and UV/Vis spectroscopy as well as elemental analysis. The tetravalent compounds were further analyzed for their magnetic susceptibility by using Evans’ method.
A Strategy for Breaking Polyoxometalate‐based MOFs To Obtain High Loading Amounts of Nanosized Polyoxometalate Clusters to Improve the Performance of Dye‐sensitized Solar Cells
Authors: Zheng Xiaotao , Chen Weilin , Chen Li , Wang Yijing , Guo Xiangwei , Wang Jiabo , Wang Enbo 
Published: March 2017

AbstractPolyoxometalates (POM) have already been confirmed to act as effective electron‐transfer mediators for improving the power conversion efficiency (PCE) of dye‐sensitized solar cells (DSSCs) based on previous studies. However, the improvement may be limited by the agglomeration of the polyoxoanions. In this paper, the previous synthesis strategy is improved upon by breaking the metal‐organic frameworks (MOFs) with POMs as the secondary building units ([Ni(bpp)(H2O)2]3[P2W18O62]⋅24 H2O (1) (bpp=1,3‐bis(4‐pyridyl)propane) and H6[Cu3(H2O)6(P2W18O62)2(3‐dpye)6]⋅28 H2O (2) (3‐dpye=N,N′‐bis(3‐pyridinecarboxamide)‐1,2‐ethane)) to design and synthesize small sized and highly disperse POM nanoparticles by means of compositing with TiO2, through calcination to remove the organic ligand. TEM and element mapping confirm that P2W18O626− (denoted as P2W18) nanoparticles with the diameter of ≈1 nm are uniformly distributed in TiO2 composites. The loading amount (wt. %) of POM in MOFs reaches 75.67 %. The small sized and highly disperse P2W18 nanoparticles may provide more active sites and specific surface areas for improving the PCE of DSSCs. Finally, the investigations indicate that the PCE of composite P2W18⋅NiO@TiO2 photoanodes is up to 7.56 %, which was 26 % higher than the pristine TiO2 based photoanodes.
Probing Zeolite Crystal Architecture and Structural Imperfections using Differently Sized Fluorescent Organic Probe Molecules
Authors: Hendriks Frank C. , Schmidt Joel E. , Rombouts Jeroen A. , Lammertsma Koop , Bruijnincx Pieter C. A. , Weckhuysen Bert M. 
Published: March 2017

AbstractInvited for the cover of this issue is the group of Bert M. Weckhuysen at Utrecht University. The image depicts the probe molecule‐based staining method applied to large zeolite crystals, and is drawn with inspiration from the well‐known surrealist artist Salvador Dalí. Read the full text of the article at 10.1002/chem.201700078.
Hydroisomerization of Long‐Chain n‐Alkanes on Bifunctional Zeolite Catalysts
Authors: Zschiesche Christopher , Himsl Dieter , Rakoczy Rainer , Reitzmann Andreas , Freiding Jens , Wilde Nicole , Gläser Roger 
Published: March 2017

AbstractDie Hydroisomerisierung eines C10 – C13‐n‐Alkangemisches wurde an sechs bifunktionellen, platinhaltigen Zeolith‐Katalysatoren mit 10‐ und 12‐Ring‐Porensystemen untersucht. Die Katalysatoren mit 12‐Ring‐Porensystemen zeigen eine höhere Aktivität als die mit 10‐Ring‐Porensystemen. Dagegen werden an den 10‐Ring‐Zeolithen aufgrund formselektiver Eigenschaften höhere Ausbeuten an den gewünschten einfach verzweigten Isomeren erhalten. Für die 10‐Ring‐Zeolithe werden jedoch höhere Reaktionstemperaturen für das Erreichen der maximalen Isomerenausbeuten benötigt. Dies führt im Vergleich zu den 12‐Ring‐Zeolithen zu mehr Spaltprodukten.
Percutaneous biopsy of the renal mass: FNA or core needle biopsy?
Authors: Yang Chi‐Shun , Choi Euna , Idrees Muhammad T. , Chen Shaoxiong , Wu Howard H. 
Published: March 2017

BACKGROUNDIn recent years, there have been increasing indications for percutaneous renal biopsy. Fine‐needle aspiration (FNA), with or without core needle biopsy (CB), has been used increasingly in the management of renal tumors at the study institution.METHODSA computerized search of laboratory records was conducted to retrieve FNA cases of renal masses as well as the correlating CB and/or nephrectomy specimens. The cases spanned a period of 10 years (2006‐2015). The diagnoses were classified into 5 categories: malignant, suspicious for malignancy, neoplastic, atypical, and negative/nondiagnostic. Based on the results of the nephrectomy specimens, the diagnostic rate, sensitivity, and diagnostic accuracy were calculated among 3 groups of specimens: FNA only, CB only, and combined FNA and CB.RESULTSA total of 247 cases of FNA with 123 correlating CB and 101 follow‐up nephrectomy specimens were identified. The diagnostic rate, sensitivity, and diagnostic accuracy were 72%, 78%, and 96%, respectively, for FNA; 87%, 92%, and 94%, respectively, for CB; and 92%, 92%, and 94%, respectively, for the combined FNA and CB group. Renal cell carcinoma and its variants were the most common histologic diagnoses (112 of 174 cases; 64%). Significant diagnostic discrepancy was noted in one case: a malignant melanoma that was misdiagnosed as renal cell carcinoma in both the preoperative FNA specimen and in the CB specimen.CONCLUSIONSIn the current study, both FNA and CB demonstrated excellent diagnostic accuracy (96% and 94%, respectively). The combination of FNA and CB was found to significantly improve the diagnostic rate when compared with either FNA alone (92% vs 72%; P<.05) or CB alone (92% vs 87%). Cancer Cytopathol 2017;125:407–15. © 2017 American Cancer Society.
CeIV–GdIII Mixed Oxides as Hosts for ErIII‐Based Upconversion Phosphors
Authors: Sorbello Cecilia , Gross Petra , Strassert Cristian A. , Jobbágy Matías , Barja Beatriz C. 
Published: March 2017

AbstractA family of ErIII and ErIII–YbIII based nanophosphors, hosted in monophasic oxidic CeIV–GdIII binary solid solutions, was prepared. The samples were formulated with a constant ErIII content as the activator, with the eventual addition of YbIII as a sensitizer. The amorphous Ce0.94−xGdxEr0.06(OH)CO3⋅H2O and Ce0.94−xGdxEr0.05Yb0.01(OH)CO3⋅H2O precursors were prepared by following the urea method to obtain monodispersed spheres of tunable size ranging from 30 to 450 nm. After being decomposed at 1273 K under an atmosphere of air, the precursors of 200 nm in diameter evolved into monophasic polycrystalline particles preserving the parent shape and size. The role of the composition of the binary matrices in the emission properties was evaluated for two different excitation wavelengths (976 nm and 780 nm) based on the upconversion (UC) emission spectra and their dependence on the incident power. The yield of the UC process is discussed in the framework of established and novel alternative mechanisms. The number of vacancies and mainly the symmetry of the ErIII environment play major roles in the deactivation pathways of the UC emission mechanisms. However, the colours obtained by employing bare CeIV or GdIII hosts are preserved in the related monophasic CeIV‐rich or GdIII‐rich binary hosts.
Direct Electron Transfer of Cellobiose Dehydrogenase on Positively Charged Polyethyleneimine Gold Nanoparticles
Authors: Tavahodi Mojtaba , Ortiz Roberto , Schulz Christopher , Ekhtiari Ali , Ludwig Roland , Haghighi Behzad , Gorton Lo 
Published: March 2017

AbstractInvited for this month's cover is the group of Prof. Dr. Lo Gorton at Lund University, Sweden. The cover picture shows a biosensor for measuring lactose in dairy products. It consists of a gold electrode, onto which a layer of polyethyleneimine‐capped gold nanoparticles is deposited. Read the full text of the article at 10.1002/cplu.201600453.
On the security of an RFID‐based parking lot management system
Authors: Safkhani Masoumeh , Bagheri Nasour , Hosseinzadeh Mehdi , Eslamnezhad Namin Mojtaba , Rostampour Samad 
Published: March 2017

SummaryRadio Frequency Identification (RFID)‐based parking management systems provide facilities to control parking lot systems within easy access and secure inspection. Chen and Chong have presented a scheme to prevent car thefts for parking lot management systems, which is based on EPC C1‐G2 RFID standard. They claimed that their protocol is resistant against well‐known RFID attacks. In this paper, we prove that Chen and Chong's scheme is not resistant against secret disclosure and impersonation attacks. Therefore, in Chen and Chong parking lot system, a car may be stolen without having a valid tag. In this paper, we also show that the proposed impersonation attack works for any length of cyclic redundancy check and the secret disclosure attack costs at most 216 evaluations of the used pseudo random number generator. The success probability of both attacks is 1 while their complexity is only 2 runs of the protocol. Finally, we present an improved protocol and formally and informally prove that the improved protocol provides the desired level of security and privacy.
Mitochondrial function and bioenergetic trade‐offs during lactation in the house mouse (Mus musculus)
Authors: Mowry Annelise V. , Donoviel Zachary S. , Kavazis Andreas N. , Hood Wendy R. 
Published: March 2017

AbstractEnergy allocation theory predicts that a lactating female should alter the energetic demands of its organ systems in a manner that maximizes nutrient allocation to reproduction while reducing nutrient use for tasks that are not vital to immediate survival. We posit that organ‐specific plasticity in the function of mitochondria plays a key role in mediating these energetic trade‐offs. The goal of this project was to evaluate mitochondrial changes that occur in response to lactation in two of the most energetically demanding organs in the body of a rodent, the liver and skeletal muscle. This work was conducted in wild‐derived house mice (Mus musculus) kept in seminatural enclosures that allow the mice to maintain a natural social structure and move within a home range size typical of wild mice. Tissues were collected from females at peak lactation and from age‐matched nonreproductive females. Mitochondrial respiration, oxidative damage, antioxidant, PGC‐1α, and uncoupling protein levels were compared between lactating and nonreproductive females. Our findings suggest that both liver and skeletal muscle downregulate specific antioxidant proteins during lactation. The liver, but not skeletal muscle, of lactating females displayed higher oxidative damage than nonreproductive females. The liver mass of lactating females increased, but the liver displayed no change in mitochondrial respiratory control ratio. Skeletal muscle mass and mitochondrial respiratory control ratio were not different between groups. However, the respiratory function of skeletal muscle did vary among lactating females as a function of stage of concurrent pregnancy, litter size, and mass of the mammary glands. The observed changes are predicted to increase the efficiency of skeletal muscle mitochondria, reducing the substrate demands of skeletal muscle during lactation. Differences between our results and prior studies highlight the role that an animals’ social and physical environment could play in how it adapts to the energetic demands of reproduction.
Reduced reproductive performance associated with warmer ambient temperatures during incubation in a winter‐breeding, food‐storing passerine
Authors: Whelan Shannon , Strickland Dan , Morand‐Ferron Julie , Norris D. Ryan 
Published: March 2017

AbstractTiming of reproduction can influence individual fitness whereby early breeders tend to have higher reproductive success than late breeders. However, the fitness consequences of timing of breeding may also be influenced by environmental conditions after the commencement of breeding. We tested whether ambient temperatures during the incubation and early nestling periods modulated the effect of laying date on brood size and dominant juvenile survival in gray jays (Perisoreus canadensis), a sedentary boreal species whose late winter nesting depends, in part, on caches of perishable food. Previous evidence has suggested that warmer temperatures degrade the quality of these food hoards, and we asked whether warmer ambient temperatures during the incubation and early nestling periods would be associated with smaller brood sizes and lower summer survival of dominant juveniles. We used 38 years of data from a range‐edge population of gray jays in Algonquin Provincial Park, Ontario, where the population has declined over 50% since the study began. Consistent with the “hoard‐rot” hypothesis, we found that cold temperatures during incubation were associated with larger brood sizes in later breeding attempts, but temperatures had little effect on brood size for females breeding early in the season. This is the first evidence that laying date and temperature during incubation interactively influence brood size in any bird species. We did not find evidence that ambient temperatures during the incubation period or early part of the nestling period influenced summer survival of dominant juveniles. Our findings provide evidence that warming temperatures are associated with some aspects of reduced reproductive performance in a species that is reliant on cold temperatures to store perishable food caches, some of which are later consumed during the reproductive period.